gebhart/patrepeval huggingface dataset:
편두통 환자의 뇌혈류에 대한 침치료의 효과 (2001)

【Objective : To investigate the effects of Acupuncture therapy on the migraineur by way of the change of the Cerebral blood flow. Methods : 6 migraineurs were inserted in acupoints on GV16, G20, S8 during 2 weeks. and, Mean Velocity (MV) and Pulsatility Index (PI) of MCA, PCA, ACA, BA were measured before and after treatments of 2 weeks, respectively. Results : MV of MCA of the migraineurs was decreased very much by 13.3%, and PI was decreased much by 10.4%. However, MV and PI of BA changed little. Conclusion : It is observed that Acupuncture therapy reduces pains of migraineur through decreasing Cerebral blood flow like MCA.】
Research on a novel hybrid cascade multilevel converter (2007)

This paper proposed a novel hybrid cascade multilevel converter in which a Neutral-Point-Clamped (NPC) converter and several identical H-Bridge converters with equal dc bus voltage are series connected to form a converter phase leg. Accordingly, for the novel converter a hybrid modulation method which incorporates square-wave synthesis in conjunction with triangle carried-based PWM method is employed. For the NPC converter, the neutral-point balance problem is analyzed and solved by a Bang-Bang control method. Digital controller design which is the parallel connection of PD control and repetitive control is presented. Simulation and experiment results are provided.
Capillary and arterial cerebral amyloid angiopathy in Alzheimer's disease: defining the perivascular route for the elimination of amyloid β from the human brain (2003)

Accumulation of amyloid beta (Abeta) in the extracellular spaces of the cerebral cortex and in blood vessel walls as cerebral amyloid angiopathy is a characteristic of Alzheimer's disease (AD) and the ageing human brain. Studies in animals suggest that Abeta is eliminated from the brain either directly into the blood or along perivascular interstitial fluid drainage channels. The aim of the present study is to define the perivascular route for the drainage of Abeta from the human brain. Smears and paraffin sections of post-mortem cortical tissue from 17 cases of AD and from two controls were stained with thioflavin and for Abeta by immunohistochemistry. Histology and confocal microscopy showed that deposits of Abeta in the cortical parenchyma were continuous with Abeta in capillary walls but Abeta in artery walls was not in continuity with Abeta in brain parenchyma. Quantitative studies supported these observations. The results of this study suggest that when Abeta is eliminated from the extracellular spaces of the human brain by the perivascular route, it enters pericapillary spaces and from there drains along the walls of cortical arteries to leptomeningeal arteries. Factors such as overproduction of Abeta, entrapment of Abeta in drainage pathways and poor drainage of Abeta due to functional changes in ageing arteries might result in the failure of elimination of Abeta from the ageing brain and play a major role in the pathogenesis of AD. Such factors might affect therapies for AD that entail administration of anti-Abeta antibodies to eliminate Abeta from the human brain.
A Novel Caffeic Acid Derivative and Other Constituents of Populus Bud Excretion and Propolis (Bee-Glue) (1987)

Abstract The bud exudates of Populus nigra, P. trichocarpa, and P. grandidentata × tremuloides were analyzed for the presence of phenolics and flavonoids. A novel natural product, caffeic acid y.y-dimethylallyl ester, was identified from P. nigra, along with further phenolics such as ρ-hydroxy-acetophenone, dimethyl caffeic acid, cinnamoyl cinnamata and vanillin. The flavonoid aglycones correspond to those reported earlier. Propolis samples from the Sonoran Desert were shown to exhibit the flavonoid pattern that is typical for poplar bud exudates, thus confirming this material as the major source for bee-glue. Only a single flavonoid might originate from the leaf exudate of a desert shrub.
A rule-based adaptive PID controller (2003)

The authors describe a functioning expert controller implemented with industrial programmable logic controller technology. In its present state the controller implements an adaptive PID (proportional, integral, and derivative) algorithm based on rule-based logical modules. The controller does not presume a model for the system. It detects several features of the current system response to a step input change and uses a pattern matching procedure to adjust the PID parameters to reshape the system output response.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Modelocked Cavity--Enhanced Absorption Spectroscopy (2002)

We demonstrate the principle of cavity enhanced absorption with femtosecond modelocked lasers. The wide spectral coverage allowed by these sources makes this a promising high-sensitivity linear absorption technique. The uniformity of the modelocked frequency comb is the feature allowing effective injection of a high finesse cavity. The smooth and stable laser spectral profile guarantees a good background for the intracavity sample absorption spectrum, recorded by a spectrograph and a linear detector array. With a modelocked Ti:Sa laser and a cavity of finesse F 420 (F/pi is the enhancement factor) we obtain a 4nm section of a weak overtone band in 40 ms with 0.2 cm-1resolution,a nd a detection limit of 2x10-7/cm/ radicalHz.
A single-chip multimode receiver for GSM900, DCS1800, PCS1900, and WCDMA (2003)

A single-chip, multimode receiver for GSM900, DCS1800, PCS1900, and UTRA/FDD WCDMA is introduced in this paper. The receiver operates at four different radio frequencies with two different baseband bandwidths. The presented chip uses a direct-conversion architecture and consists of a low-noise amplifier (LNA), downconversion mixers with on-chip local-oscillator I/Q generation, channel selection filters, and programmable gain amplifiers. In spite of four receive bands, only four on-chip inductors are used in the single-ended LNA. The repeatable receiver second-order input intercept point (IIP2) of over +42 dBm is achieved with mixer linearization circuitry together with a baseband circuitry having approximately +100-dBV out-of-band IIP2. The noise figure of the SiGe BiCMOS receiver is less than 4.8 dB in all GSM modes, and 3.5 dB in WCDMA. The power consumption from a 2.7-V supply in all GSM modes and in WCDMA mode is 42 and 50 mW, respectively. The silicon area is 9.8 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> including the bonding pads.
Effect of long-term treatment with recombinant human interleukin-3 in patients with myelodysplastic syndromes. (1993)

In a phase II study, involving nine patients with refractory anemia or refractory anemia with ring sideroblasts, the effects of treatment with recombinant human interleukin-3 (IL-3) on hematopoietic function were assessed. Doses of IL-3 ranging from 60 micrograms/m2 during weeks 1-6 to 125 micrograms/m2 during weeks 7-12 were administered as subcutaneous bolus injections three times per week for 12 weeks. Platelet counts increased in six patients. Platelet increase correlated with stable or decreased serum tumour necrosis factor alpha (TNF-alpha) levels, while an increase of TNF-alpha levels during IL-3 therapy occurred in patients with no change or a decrease of platelet counts. Leukocyte counts increased in two patients and reticulocytes in three, without an effect on hemoglobin levels. Morphological analysis of the bone marrow revealed an expansion of the myeloid compartment in seven of eight evaluable patients, mainly due to stimulation of the precursor cells. No improvement of the in vitro growth of hematopoietic progenitor cells was observed. Sequential cytogenetic analyses indicate that IL-3 treatment does not act preferentially on either the cytogenetically abnormal or the normal clones. These results suggest that long-term treatment with low-dose IL-3 stimulates megakaryopoiesis with increase of platelet counts, but that additional later-acting cytokines probably will be required to augment neutrophil and erythrocyte counts.
A network file system over HTTP: remote access and modification of files and "files" (2000)

The goal of the present HTTPFS project is to enable access to remote files, directories, and other containers through an HTTP pipe. HTTPFS system permits retrieval, creation and modification of these resources as if they were regular files and directories on a local filesystem. The remote host can be any UNIX or Win9x/WinNT box that is capable of running a Perl CGI script and accessible either directly or via a web proxy or a gateway. HTTPFS runs entirely in user space. The current implementation fully supports reading as well as creating, writing, appending, and truncating of files on a remote HTTP host. HTTPFS provides an isolation level for concurrent file access stronger than the one mandated by POSIX file system semantics, closer to that of AFS. Both an API with familiar open(), read(), write(), close(), etc. calls, and an interactive interface, via the popular Midnight Commander file browser, are provided.
Non-contact method for directing electrotaxis (2015)

We present a method to induce electric fields and drive electrotaxis (galvanotaxis) without the need for electrodes to be in contact with the media containing the cell cultures. We report experimental results using a modification of the transmembrane assay, demonstrating the hindrance of migration of breast cancer cells (SCP2) when an induced a.c. electric field is present in the appropriate direction (i.e. in the direction of migration). Of significance is that migration of these cells is hindered at electric field strengths many orders of magnitude (5 to 6) below those previously reported for d.c. electrotaxis, and even in the presence of a chemokine (SDF-1α) or a growth factor (EGF). Induced a.c. electric fields applied in the direction of migration are also shown to hinder motility of non-transformed human mammary epithelial cells (MCF10A) in the presence of the growth factor EGF. In addition, we also show how our method can be applied to other cell migration assays (scratch assay), and by changing the coil design and holder, that it is also compatible with commercially available multi-well culture plates.
Cooperative spectrum sensing in cognitive radio networks under Gaussian fusion channels (2009)

This paper presents cooperative spectrum sensing in cognitive radio networks under Gaussian fusion channels. The global detection performance is evaluated based on Neyman-Pearson (NP) detection and using equal gain combining (EGC) fusion rule. It is shown that, under a global signal to noise ratio (SNR) constraint, the global detection performance can be maximized by choosing an appropriate local energy threshold. Furthermore, asymptotic performance is investigated assuming large numbers of secondary users and samples used for local energy calculation.
Two-photon induced fluorescence of diarylethene molecule (2002)

A diarylethene derivative with thermally irreversible photochromic reactivity and good fatigue resistance has been synthesized. The two-photon-induced fluorescence of the compound is observed by excited with 800 nm beam. The intensity of the fluorescence is found to be proportional to <i>I</i><sup>1.748</sup>, where <i>I</i> is the incident laser intensity, and decays with the increase of irradiation time. The results show that two-photon induced nonlinear photochromic reaction was partially realized. It demonstrates that the compound is a promising candidate for two-photon 3D optical data storage.
Mechanism of insulin‐like growth factor I‐mediated proliferation of adult neural progenitor cells: role of Akt (2007)

Insulin-like growth factor I (IGF-I) is involved in the proliferation and differentiation of adult neural progenitor cells; however, the underlying mechanism is not clear. We analysed the involvement of the phosphatidylinositol 3-kinase/Akt and MEK/extracellular signal-regulated kinase (ERK) pathways in the IGF-I-mediated proliferation of rat neural progenitor cells. Stimulation of neural progenitor cells with IGF-I enhanced the phosphorylation of Akt but not ERK. Cell proliferation assay demonstrated that 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (phosphoinositide 3-kinase inhibitor) but not 1,4-diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)-butadiene (U0126) (ERK inhibitor) inhibited the IGF-I-induced survival of cells, whereas fibroblast growth factor 2 (FGF-2) enhanced the IGF-I-mediated survival of cells. Consistent with the cell proliferation assay, 5'bromo-2-deoxy-uridine incorporation studies established a negative role for IGF-I in proliferation. However, FGF-2 (ERK activator) in the presence of IGF-I (Akt activator) increased the proliferation of cells. Accordingly, stimulation of the ERK pathway by FGF-2 induced the expression of cyclin D1, which is essential for the entry of cells into cell cycle, and IGF-I in the presence of FGF-2 up-regulated the expression of cyclin D1. IGF-I in the absence or presence of FGF-2 increased the phosphorylation of glycogen synthase kinase, thus supporting its role in the survival of neural progenitor cells. To further confirm the role of ERK activation in the proliferation, we cultured cells in FGF-2 + IGF-I-containing medium in the presence and absence of U0126 (ERK inhibitor), and showed the inhibition of nestin expression in U0126-treated cells. The decrease in the cyclin D1 content in conjunction with the inhibition of nestin expression by ERK inhibitor confirms the role of ERK in the proliferation of cells.
High-speed optical parametric oscillator pumped with an electronically tuned Ti:sapphire laser (1997)

High-speed and random-access tuning of output wavelengths was achieved in an optical parametric oscillator pumped with an electronically tuned Ti:sapphire laser, which was fully under computer control. The signal and idler wavelengths in 90° phase-matched KTiOPO4 were scanned without mechanical rotation of crystals or mirrors. Signal waves in the range from 1.06 to 1.31 μm and idler waves in the range from 2.27 to 2.97 μm accessed in random order by setting the pumping wavelengths between 713 and 923 nm.
Safety valve and burst disk capacity for two phase flow in geothermal applications (2016)

Sizing calculations for two-phase flow (steam and water) through safety pressure relief valves (PRV) and burst disks are critical for plant safety. There are no universally accepted methods for sizing these devices. This paper provides a comparison between test data collected during the Ohaaki geothermal field commissioning and common valve sizing methods. Theoretical values of mass flow rate, calculated by HEM/omega method and by the Russell James formula were compared with tested flows and show that the omega method underestimates the mass flow rate in the range of conditions tested while the Russell James formula values are a better match to the test results and the range of conditions encountered in geothermal power plants.
Small‐molecule protein–protein interaction inhibitors: Therapeutic potential in light of molecular size, chemical space, and ligand binding efficiency considerations (2010)

As the ultimate function of proteins depends to a great extent on their binding partners, protein-protein interactions (PPIs) represent a treasure trove of possible new therapeutic targets. Unfortunately, interfaces involved in PPIs are not well-suited for effective small molecule binding. Nevertheless, successful examples of small-molecule PPI inhibitors (PPIIs) are beginning to accumulate, and the sheer number of PPIs that form the human interactome implies that, despite the relative unsuitability of PPIs to serve as "druggable" targets, small-molecule PPIIs can still provide novel pharmacological tools and new innovative drugs in at least some areas. Here, after some illustrative examples, accumulating information on the binding efficiency, molecular size, and chemical space requirements will be briefly reviewed. Therapeutic success can only be achieved if these considerations are incorporated into the search process and if careful medicinal chemistry approaches are used to address the absorption, distribution, metabolism, and excretion requirements of larger molecules that are often needed for this target class due to the lower efficiency of binding.
Steroids. LXI.<sup>1</sup> Synthesis of 19-Nor-desoxycorticosterone, a Potent Mineralocorticoid Hormone<sup>2</sup> (1955)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSteroids. LXI.1 Synthesis of 19-Nor-desoxycorticosterone, a Potent Mineralocorticoid Hormone2A. Sandoval, G. H. Thomas, Carl Djerassi, G. Rosenkranz, and Franz SondheimerCite this: J. Am. Chem. Soc. 1955, 77, 1, 148–151Publication Date (Print):January 1, 1955Publication History Published online1 May 2002Published inissue 1 January 1955https://pubs.acs.org/doi/10.1021/ja01606a045https://doi.org/10.1021/ja01606a045research-articleACS PublicationsRequest reuse permissionsArticle Views115Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Development of 400 Vdc power distribution system and 400 Vdc output rectifier (2009)

We outline the specifications and performance of a 400 V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">dc</sub> power distribution system with a 400 V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">dc</sub> output rectifier. In 2008, The NTT-group have began developing a 400 V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">dc</sub> distribution system for reducing power consumption and the usage of materials, such as copper in power cables. In conjunction with this project, NTT facilities has developed prototype rectifiers, a prototype voltage compensator used during interruption periods, and a prototype battery charger. These exhibit higher efficiency than conventional ones and also exhibit high output regulation to adapt charge condition required by valve-regulated lead acid batteries for backup.
NMR Imaging of Catalytic Hydrogenation in Microreactors with the Use of para-Hydrogen (2008)

Catalysis is vital to industrial chemistry, and the optimization of catalytic reactors attracts considerable resources. It has proven challenging to correlate the active regions in heterogeneous catalyst beds with morphology and to monitor multistep reactions within the bed. We demonstrate techniques, using magnetic resonance imaging and para-hydrogen (p-H2) polarization, that allow direct visualization of gas-phase flow and the density of active catalyst in a packed-bed microreactor, as well as control over the dynamics of the polarized state in space and time to facilitate the study of subsequent reactions. These procedures are suitable for characterizing reactors and reactions in microfluidic devices where low sensitivity of conventional magnetic resonance would otherwise be the limiting factor.
The effectiveness of mental health-related theoretical education and clinical placement in mental health settings in changing the attitudes of health care students towards mental illness: A systematic review (2012)

JBI Evidence Synthesis is an international peer-reviewed, online journal that publishes manuscripts encompassing evidence synthesis and healthcare. JBI Evidence Synthesis seeks to disseminate rigorous, high-quality research that provides the best available evidence to inform policy and practice through the science and conduct of systematic and scoping reviews. The journal publishes systematic and scoping review protocols, diverse types of systematic reviews, and scoping reviews covering multi-disciplinary healthcare-related topics that follow methodology and methods developed by JBI. The journal also publishes editorials, letters to the editor as well as original applied research and discussion papers examining synthesis methods. JBI Evidence Synthesis does not accept systematic reviews of in vitro or animal studies. JBI Evidence Synthesis co-publishes JBI methodology and methods with its partner JBI journal, JBI Evidence Implementation.
A 28-nm 1R1W Two-Port 8T SRAM Macro With Screening Circuitry Against Read Disturbance and Wordline Coupling Noise Failures (2018)

We demonstrate a 1-read/1-write two-port (2P) embedded static random access memory macro based on 8T SRAM bitcell with an effective scheme for design of testability. To achieve a smaller macro area, a differential sense amplifier is introduced to read out the data, where the reference voltage for reading 0/1 data is generated by an unselected bitcell array. In addition, we propose a screening test circuit for read disturbance and wordline coupling noise. A 512-kbit 2P SRAM macro using 28-nm high-K/metal gate bulk CMOS technology has been designed, confirming experimentally that the worst minimum operation voltage ( <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$V_{\text {min}}$ </tex-math></inline-formula> ) can be reproduced by our test circuit. Bit density of 3.16 Mb/mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> was achieved.
Fast mode decision for inter frames in H.264/AVC (2006)

The H.264/AVC video coding standard can achieve considerably higher coding efficiency than any previous standards. Unfortunately this comes from dramatically high coding complexity introduced mainly by multi-mode checking scheme when coding macroblocks. Base on statistically analyzing the best mode situations, a progressively adaptive fast mode decision algorithm is proposed in this paper to reduce the coding complexity of inter frames in H.264/AVC. Experimental results show that the proposed algorithm can averagely save about 75.3% coding time compared with the reference software with only about 0.15% bitrate increase and 0.15dB PSNR loss.