gebhart/patrepeval huggingface dataset:
An ID-based Broadcast Encryption Scheme for Collaborative Design (2009)

Collaborative design is one of core processes for networked manufacturing, so how to safely transfer design information in the network has important significance. In order to provide the confidentiality of transmission information on the level of design team in collaborative design system, a new broadcast encryption scheme based on designer’s identity is presented. The new scheme is based on broadcast encryption theory. By introducing master key of design teams and distributing the public and secret parameters reasonably, every designer can encrypt design documents and transmit them expediently. The encrypted document can be decrypted only by the members of the designated design team. In the new scheme the private key escrow problem of ID-based public key system is solved. Analysis shows that the new scheme is secure under the discrete logarithm assumption and users out of the designated design team can’t decrypt the documents. The new scheme can be used in the collaborative design system to protect the security of design information.
Fast Discrete Intersection Detection for Cloth Penetration Resolution (2015)

Penetrations are often unavoidable in modeling cloth or other deformable surfaces. It could exist as an initial configuration or show up in the middle of a dynamics simulation process. We present a new method for resolving such penetrations. To be adapted to a wide range of applications, this method is based on history-free discrete intersection detection (DID). It is also orientation-free as it does not assume any front- and back-face identification. Our method relies on dynamic repulsive normal (DRN) to compute proper displacements to relocate vertices to be intersection-free. First, intersection contours are constructed and classified, followed by a global analysis of the collision configurations. Then for some types of configurations, penetrating (illegal) regions are identified using a heuristic paradigm "small region is illegal". For those surfaces having identifiable illegal regions, proper displacements for incorrectly configured vertices are computed using DRN. For those configurations that do not clearly define legal/illegal regions, displacements are designed to push one mesh to the boundary of the other. The proposed method can also be used in the context of time-dependent simulation of complex deformable surfaces, making it an competitive alternative to the popular CCD-based approach.
Enhanced detection of gold nanoparticles in agarose gel electrophoresis (2012)

Gel electrophoresis is a powerful tool in gold nanoparticle (AuNP) research. While the technique is sensitive to the size, charge, and shape of particles, its optimal performance requires a relatively large amount of AuNP in the loading wells for visible detection of bands. We here describe a novel and more sensitive method for detecting AuNPs in agarose gels that involves staining the gel with the common organic fluorophore fluorescein, to produce AuNP band intensities that are linear with nanoparticle concentration and almost an order of magnitude larger than those obtained without staining the gel.
Enzyme‐aided construction of medium‐sized alditols of complete O‐linked saccharides (1994)

We have constructed by enzyme-aided in vitro synthesis a hexasaccharide alditol Gal beta 1-4GlcNAc beta 1-6Gal beta 1-4GlcNAc beta 1-6(Gal beta 1-3) GalNAc-ol and shown that it resists the action of endo-beta-galactosidase from Bacteroides fragilis under conditions where a related pentasaccharide alditol, GlcNAc beta 1-3Gal beta 1-4GlcNAc beta 1-6(Gal beta 1-3)GalNAc-ol, was completely cleaved. Together with earlier results from this laboratory, our present data imply that endo-beta-galactosidase from B. fragilis, apparently, can be used to distinguish between GlcNAc beta 1-6Gal and GlcNAc beta 1-3Gal units within linear backbone sequences of all known types of oligo-(N-acetyllactosamino)glycans.
Fluoxetine and suicide: a meta-analysis of controlled trials of treatment for depression. (1991)

Data from these trials do not show that fluoxetine is associated with an increased risk of suicidal acts or emergence of substantial suicidal thoughts among depressed patients.
Role of caveolae in signal-transducing function of cardiac Na<sup>+</sup>/K<sup>+</sup>-ATPase (2003)

Ouabain binding to Na(+)/K(+)-ATPase activates Src/epidermal growth factor receptor (EGFR) to initiate multiple signal pathways that regulate growth. In cardiac myocytes and the intact heart, the early ouabain-induced pathways that cause rapid activations of ERK1/2 also regulate intracellular Ca(2+) concentration ([Ca(2+)](i)) and contractility. The goal of this study was to explore the role of caveolae in these early signaling events. Subunits of Na(+)/K(+)-ATPase were detected by immunoblot analysis in caveolae isolated from cardiac myocytes, cardiac ventricles, kidney cell lines, and kidney outer medulla by established detergent-free procedures. Isolated rat cardiac caveolae contained Src, EGFR, ERK1/2, and 20-30% of cellular contents of alpha(1)- and alpha(2)-isoforms of Na(+)/K(+)-ATPase, along with nearly all of cellular caveolin-3. Immunofluorescence microscopy of adult cardiac myocytes showed the presence of caveolin-3 and alpha-isoforms in peripheral sarcolemma and T tubules and suggested their partial colocalization. Exposure of contracting isolated rat hearts to a positive inotropic dose of ouabain and analysis of isolated cardiac caveolae showed that ouabain caused 1) no change in total caveolar ERK1/2, but a two- to threefold increase in caveolar phosphorylated/activated ERK1/2; 2) no change in caveolar alpha(1)-isoform and caveolin-3; and 3) 50-60% increases in caveolar Src and alpha(2)-isoform. These findings, in conjunction with previous observations, show that components of the pathways that link Na(+)/K(+)-ATPase to ERK1/2 and [Ca(2+)](i) are organized within cardiac caveolae microdomains. They also suggest that ouabain-induced recruitments of Src and alpha(2)-isoform to caveolae are involved in the manifestation of the positive inotropic effect of ouabain.
Coated Textiles in the Treatment of Atopic Dermatitis (2006)

Atopic dermatitis (AD) is a chronic inflammatory skin disease with increasing prevalence over the last few decades. Various factors are known to aggravate the disease. In particular, wool and synthetic fabrics with harsh textile fibres, aggressive detergents and climatic factors may exacerbate AD. Cutaneous superinfection, particularly with Staphylococcus aureus, is also recognized as an important factor in the elicitation and maintenance of skin inflammation and acute exacerbations of AD. The severity of AD correlates with S. aureus colonization of the skin. Beside the treatment of AD patients with creams and emollients, new developments in the textile industry may have therapeutic implications. Silk or silvercoated textiles show antimicrobial properties that can significantly reduce the burden of S. aureus, leading to a positive effect on AD. Silver products have been used as wound dressing, whereby silver has antiseptic properties, and drug resistance is hardly found. Padycare textiles consist of micromesh material containing woven silver filaments with a total silver content of 20%. In vitro studies of these silver-coated textiles demonstrated a significant decrease in S. aureus and Pseudomonas aeruginosa as well as Candida albicans. Silk has been increasingly implemented in medical treatment of AD thanks to its unique smoothness that reduces irritation. Silk can be coated with antimicrobials (Dermasilk). The combination of the smoothness of silk with an antimicrobial finish appears to make an ideal textile for patients suffering from AD.
High Temperature Gas Chromatography and High Temperature Gas Chromatography - Negative Chemical Ionization Mass Spectrometry of Derivatized Triglycerides Containing Oxygenated Fatty Acid Acyl Groups (1998)

Five seed oils consisting of unusual triacylglycerols have been examined by high temperature gas chromatography using glass capillary columns coated with the stationary phase SOP-50 (50%-diphenyl-50%-dimethylpolysiloxane, methoxy-terminated). The investigated hydroxy, epoxy, and ketokonjuene triacylglycerols were first derivatized in order to permit analysis by high temperature gas chromatography. Structural elucidation of the intact triacylglycerols was performed with high temperature gas chromatography/negative chemical ionization-mass spectrometry using NH3 as a reagent gas. Individual derivatized lipid species with a molecular weight up to 1176 g/mol could be identified.
Comparison of Biomarker Modalities for Predicting Response to PD-1/PD-L1 Checkpoint Blockade (2019)

In this meta-analysis, tumor mutational burden, PD-L1 IHC, and GEP demonstrated comparable AUCs in predicting response to anti-PD-1/PD-L1 treatment. Multiplex immunohistochemistry/IF and multimodality biomarker strategies appear to be associated with improved performance over PD-L1 IHC, TMB, or GEP alone. Further studies with mIHC/IF and composite approaches with a larger number of patients will be required to confirm these findings. Additional study is also required to determine the most predictive analyte combinations and to determine whether biomarker modality performance varies by tumor type.
Endothelial progenitor cell transplantation improves long‐term stroke outcome in mice (2009)

We conclude that systemic delivery of EPCs protects the brain against ischemic injury, promotes neurovascular repair, and improves long-term neurobehavioral outcomes. Our data suggest that SDF-1-mediated signaling plays a critical role in EPC-mediated neuroprotection.
Clustered L0 Buffer Organization for Low Energy Embedded Processors (2002)

Current L0 or loop buffer organizations for VLIW processors are essentially centralized, as a consequence they are energy inefficient and their scalability is limited. In this context, we propose a clustered loop buffer organization, where the loop buffers are partitioned and functional units are logically grouped to form instruction clusters, along with two schemes for the buffer control which regulate the activity in each cluster. To demonstrate the efficiency of the proposed schemes, we compare their energy consumption against an uncompressed centralized buffer, a compressed centralized buffer and an uncompressed partitioned scheme with no buffer control. Furthermore, we present an extended version of our functional unit activity based clustering scheme to form instruction clusters for each application. The simulation results indicate that the energy consumed in the clustered L0 buffers is on average 63 % lower than the energy consumed in an uncompressed centralized L0 buffer.
Comparison of Nanocrystalline Surface Layer in Steels Formed by Air Blast and Ultrasonic Shot Peening (2004)

Surface nanocrystallization in various steels by shot peening (both air blast (ABSP) and ultrasonic (USSP)) was investigated. In all the shot-peened specimens, the equiaxed nanocrystals with grain size of several 10 nm were observed at the surface regions. The depth of nanocrystalline (NC) layers was several μm. The NC layers have extremely high hardness and were separated from the deformed structure regions just under the NC layers with sharp boundaries. By annealing, the NC layers show the substantially slow grain growth without recrystallization. These characteristics are similar to those observed in the specimens treated by ball milling, ball drop and particle impact deformation. Comparing ABSP and USSP at the similar peening condition, the produced volume of NC region in ABSP is larger than that in USSP.
On the chichibabin amination of pyrimidine and <i>N</i>‐alkylpyrimidinium salts using liquid ammonia/potassium permanganate (1987)

Abstract Treatment of the 2‐ R ‐pyrimidines ( 1 , R = methyl, ethyl, i ‐propyl and t ‐butyl) with potassium amide/liquid ammonia/potassium permanganate leads to amination at C‐4(6). The yields of the 4(6)‐amino compounds 3 in‐crease in the order 2‐methyl (10%), 2‐ethyl (30%), 2‐ i ‐propyl (45%) and 2‐ t ‐butyl (60%). Treatment of the 2‐R‐ N ‐methylpyrimidinium salts ( 4 , R = hydrogen, methyl) with liquid ammonia/potassium permanganate leads to a regiospecific imination at C‐6, the corresponding 2‐R‐1,6‐dihydro‐6‐imino‐1‐methylpyrimidines 6 being obtained in 80‐85% yield. It is proved by 15 N ‐labelling that no ring opening is involved in these imination reactions. Treatment of the imino compounds with base leads to the corresponding 2.R‐6‐methylamino‐pyrimidines 8 , involving, as proved by 15 N ‐labelling, an ANRORC‐mechanism. 2‐ t ‐Butyl‐1‐ethylpyrimidinium tetrafluoroborate ( 9b ) when treated with liquid ammonia/potassium permanganate undergoes N ‐deethylation, 2‐ t ‐butylpyrimidine being exclusively formed.
Biosynthesis of the N-Linked Glycan in<i>Campylobacter jejuni</i>and Addition onto Protein through Block Transfer (2006)

In eukaryotes, N-linked protein glycosylation is a universal modification involving addition of preformed oligosaccharides to select Asn-Xaa-Ser/Thr motifs and influencing multiple biological events. We recently demonstrated that Campylobacter jejuni is the first member of the Bacteria to possess an N-linked glycan pathway. In this study, high-resolution magic angle spinning nuclear magnetic resonance (HR-MAS NMR) was applied to probe and quantitate C. jejuni N-glycan biosynthesis in vivo. To confirm HR-MAS NMR findings, glycosylation mutants were screened for chicken colonization potential, and glycoproteins were examined by mass spectrometry and lectin blotting. Consistent with the mechanism in eukaryotes, the combined data indicate that bacterial glycans are assembled en bloc, emphasizing the evolutionary conservation of protein N glycosylation. We also show that under the conditions examined, PglG plays no role in glycan biosynthesis, PglI is the glucosyltransferase and the putative ABC transporter, and WlaB (renamed PglK) is required for glycan assembly. These studies underpin the mechanism of N-linked protein glycosylation in Bacteria and provide a simple model system for investigating protein glycosylation and for exploitation in glycoengineering.
Bell's Inequalities and Density Matrices: Revealing “Hidden” Nonlocality (1995)

Standard Bell inequalities apply to correlations arising when two or more macroscopically separated systems are each subjected to a single ideal measurement. While these inequalities demonstrate that quantum mechanics and local hidden variable theories yield incompatible predictions for pure states, they fail for mixed states: For mixed states, correlations arising from a single ideal measurement on each system may obey standard Bell inequalities, yet when each system is subjected to a sequence of ideal measurements the correlations are nonlocal. For some situations even this last procedure fails, and we must consider more complex (``nonideal'') measurements.
<sup>1</sup>H NMR Metabonomic Analysis in Renal Cell Carcinoma: a Possible Diagnostic Tool (2010)

(1)H NMR based metabonomic approach was applied in order to monitor the alterations of plasma metabolic profile in Renal Cell Carcinoma (RCC) patients and controls. (1)H NMR spectra of plasma samples from 32 RCC patients and 13 controls (patients exhibiting benign urologic disease) were recorded and analyzed using multivariate statistical techniques. Alterations in the levels of LDL/VLDL, NAC, lactate, and choline were observed between RCC patients and controls discriminating these groups in Principal Component Analysis (PCA) plots. Post OSC PLS-DA presented a satisfactory clustering between T1 with T3 RCC patients. Decrease in plasma lipid concentrations in RCC patients was verified using conventional clinical chemistry analysis. The results suggest that combination of (1)H NMR spectroscopy with PCA has potential in cancer diagnosis; however, a limitation of the method to monitor RCC is that major biomarkers revealed (lipoproteins and choline) in this metabolic profile are not unique to RCC but may be the result of the presence of any malignancy.
Targeted advertising in the online video space (2012)

Videology is an online video advertising, optimization, and yield management solutions provider whose business strategy is to purchase online video advertising inventory from content providers and deliver ads to their clients using behavioral and demographic targeting to maximize value. The Capstone team used a diverse set of analytical tools, including Time Series models, Principal Component analysis, Decision Tree Optimization, Generalized Linear Models, K-Means clustering, and linear programming to improve efficiency in the online video advertisement space by connecting consumers with advertisements on which they are most likely to click. Trends, patterns, and anomalies in the data may lead to new targeting opportunities for Videology.
Input Processing and Grammar Instruction in Second Language Acquisition (1997)

This book provides an alternative to the debate in second language acquisition theory and teaching. Accepting that language acquisition is at least partially input dependent, the author asks how grammatical form is processed in the input by second language learners and is it possible to assist this in ways that help the learner to create richer grammatical intake. He answers these questions and explains why traditional paradigms are not psycholinguistically motivated. Drawing on research from both first and second language acquisition, he outlines a model for input in second language acquisition that helps to account for how learners construct grammatical systems. He then uses this model to motivate processing instruction, a type of grammar instruction in which learners are engaged in making form-meaning connections during particular input activities.
Aging, Progenitor Cell Exhaustion, and Atherosclerosis (2003)

Our data indicate that progressive progenitor cell deficits may contribute to the development of atherosclerosis.
Single view augmentation of 3D elastic objects (2014)

This paper proposes an efficient method to capture and augment highly elastic objects from a single view. 3D shape recovery from a monocular video sequence is an underconstrained problem and many approaches have been proposed to enforce constraints and resolve the ambiguities. State-of-the art solutions enforce smoothness or geometric constraints, consider specific deformation properties such as inextensibility or ressort to shading constraints. However, few of them can handle properly large elastic deformations. We propose in this paper a real-time method which makes use of a mechanical model and is able to handle highly elastic objects. Our method is formulated as a energy minimization problem accounting for a non-linear elastic model constrained by external image points acquired from a monocular camera. This method prevents us from formulating restrictive assumptions and specific constraint terms in the minimization. The only parameter involved in the method is the Young's modulus where we show in experiments that a rough estimate of its value is sufficient to obtain a good reconstruction. Our method is compared to existing techniques with experiments conducted on computer-generated and real data that show the effectiveness of our approach. Experiments in the context of minimally invasive liver surgery are also provided.
Continuous HRT with Oral 17β E2 and Promege-stone: Results of a 1-Year Trial with Three Dose Reg-imen (1995)

Rozenbaum, H.; Drapier-Faure, E.; Le Nestour, E. Investigators Group for Menopause, S. Brin Author Information
Burn-Induced Nitric Oxide Release in Humans (1995)

Nitric oxide (NO) generation in a series of 20 burn patients was studied with a novel anion exchange high-performance liquid chromatographic method for the simultaneous determination of nitrite (NO2-) and nitrate (NO3-), the stable metabolic endproducts of NO. The NO values within our survivor group (n = 17) were significantly altered at days 1, 6, and 12 postburn in contrast to controls (n = 23) (p < or = 0.03). NO2- values were significantly depressed in both plasma and urine, whereas NO3- values were significantly elevated in contrast to control values (p < or = 0.03). The ratio of NO2-:NO3- was significantly lower for burn patients versus controls in both plasma and urine (p < 0.01). The NO generation seemed in part to be dependent on the percentage of total body surface area burn, most dramatically elevated in patients with burns of 10 to 40% total body surface area. In subjects who did not survive beyond 36 hours postinjury because of irreversible shock (n = 3), the production of NO was significantly depressed in contrast to survivors and controls (p < 0.0001). However, the NO2-:NO3- ratio (0.001) was relatively unchanged, with reflection of a global depression in NO formation with no change in the individual component release. Burn injury resulted in an increased release/production of NO that in the first postburn week is maximally elevated immediately postinjury. NO release, although decreased at day 6 relative to the day 1 values, remained elevated into the second week postinjury when there was evidence for a further increase in NO production. The enhanced NO3- formation may well result from NO reacting with oxygen-free radicals counteracting superoxide anion-induced destruction of tissue, thereby potentially functioning as a protectant molecule.
Average Volumetric Concentration in Two-Phase Flow Systems (1965)

A general expression which can be used either for predicting the average volumetric concentration or for analyzing and interpreting experimental data is derived. The analysis takes into account both the effect of nonuniform flow and concentration profiles as well as the effect of the local relative velocity between the phases. The first effect is taken into account by a distribution parameter, whereas the latter is accounted for by the weighted average drift velocity. Both effects are analyzed and evaluated. The results predicted by the analysis are compared with experimental data obtained for various two-phase flow regimes, with various liquid-gas mixtures in adiabatic, vertical flow over a wide pressure range. Good agreement with experimental data is shown.
Effect of osmotic pressure on the production of retroviral vectors: Enhancement in vector stability (2006)

The use of Moloney murine leukaemia virus (MoMLV) derived retroviral vectors in gene therapy requires the production of high titer preparations. However, obtaining high titers of infective MoMLV retroviral vectors is difficult due to the vector inherent instability. In this work the effect of the cell culture medium osmotic pressure upon the virus stability was studied. The osmolality of standard medium was raised from 335 up to 500 mOsm/kg using either ionic (sodium chloride) or non-ionic osmotic agents (sorbitol and fructose). It was observed that, independently of the osmotic agent used, the infectious vector inactivation rate was inversely correlated with the osmolality used in the production media; therefore, the use of high medium osmolalities enhanced vector stability. For production purposes a balance must be struck between cell yield, cell productivity and retroviral stability. From the conditions tested herein sorbitol addition, ensuring osmolalities between 410 and 450 mOsm/kg, yields the best production conditions; NaCl hampered the viral infectious production while fructose originates lower cell yields. Lipid extractions were performed for cholesterol and phospholipid analyses showing that more stable viral vectors had a 10% reduction in the cholesterol content. A similar reduction in cholesterol was observed in the producer cells. A detailed analysis of the major phospholipids composition, type and fatty acid content, by mass spectrometry did not show significant changes, confirming the decrease in the cholesterol to phospholipids ratio in the viral membrane as the major reason for the increased vector stability.