gebhart/patrepeval huggingface dataset:
Activation of the human immune system by chemotherapeutic or targeted agents combined with the oncolytic parvovirus H-1 (2011)

In our human models, chemotherapeutic or targeted agents did not only interfere with the pronounced immunomodulatory properties of H-1PV, but also reinforced drug-induced tumor cell killing. H-1PV combined with cisplatin, vincristine or sunitinib induced effective immunostimulation via a pronounced DC maturation, better cytokine release and cytotoxic T-cell activation compared with agents alone. Thus, the clinical assessment of H-1PV oncolytic tumor therapy not only alone but also in combination strategies is warranted.
Procollagen II Amino Propeptide Processing by ADAMTS-3 (2001)

The amino and carboxyl propeptides of procollagens I and II are removed by specific enzymes as a prerequisite for fibril assembly. Null mutations in procollagen I N-propeptidase (ADAMTS-2) cause dermatosparaxis in cattle and the Ehlers-Danlos syndrome (dermatosparactic type) in humans by preventing proteolytic excision of the N-propeptide of procollagen I. We have found that procollagen II is processed normally in dermatosparactic nasal cartilage, suggesting the existence of another N-propeptidase(s). We investigated such a role for ADAMTS-3 in Swarm rat chondrosarcoma RCS-LTC cells, which fail to process the procollagen II N-propeptide. Stable transfection of RCS-LTC cells with bovine ADAMTS-2 or human ADAMTS-3 partially rescued the processing defect, suggesting that ADAMTS-3 has procollagen II N-propeptidase activity. Human skin and skin fibroblasts showed 30-fold higher mRNA levels of ADAMTS-2 than ADAMTS-3, whereas ADAMTS-3 mRNA was 5-fold higher than ADAMTS-2 mRNA in human cartilage. We propose that both ADAMTS-2 and ADAMTS-3 process procollagen II, but ADAMTS-3 is physiologically more relevant, given its preferred expression in cartilage. The findings provide an explanation for the sparing of cartilage in dermatosparaxis and, perhaps, for the relative sparing of some procollagen I-containing tissues.
Stem-piped light activates phytochrome B to trigger light responses in <i>Arabidopsis thaliana</i> roots (2016)

The roles of photoreceptors and their associated signaling mechanisms have been extensively studied in plant photomorphogenesis with a major focus on the photoresponses of the shoot system. Accumulating evidence indicates that light also influences root growth and development through the light-induced release of signaling molecules that travel from the shoot to the root. We explored whether aboveground light directly influences the root system of Arabidopsis thaliana Light was efficiently conducted through the stems to the roots, where photoactivated phytochrome B (phyB) triggered expression of ELONGATED HYPOCOTYL 5 (HY5) and accumulation of HY5 protein, a transcription factor that promotes root growth in response to light. Stimulation of HY5 in response to illumination of only the shoot was reduced when root tissues carried a loss-of-function mutation in PHYB, and HY5 mutant roots exhibited alterations in root growth and gravitropism in response to shoot illumination. These findings demonstrate that the underground roots directly sense stem-piped light to monitor the aboveground light environment during plant environmental adaptation.
Applicability of TV-Type Multichannel Detectors to Spectroscopy (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTApplicability of TV-Type Multichannel Detectors to SpectroscopyYair TalmiCite this: Anal. Chem. 1975, 47, 7, 658A–670APublication Date (Print):June 1, 1975Publication History Published online24 May 2012Published inissue 1 June 1975https://doi.org/10.1021/ac60357a724RIGHTS & PERMISSIONSArticle Views18Altmetric-Citations63LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (3 MB) Get e-Alerts Get e-Alerts
Dynamic temperature control in injection molding with new conformal heating/cooling system (2010)

The cooling is an important process in injection molding. It can represent more than 60% of the total molding cycle time, affecting directly the shrinkage and warpage of the plastic part. Therefore, designing a good cooling system is very important as it greatly affects the cycle time, the quality and indirectly the price of the product. Conventional straight cooling channels are machined into mold components with gun drills. Alternative methods to create cooling channels that conforms or fits to the shape of the cavity and core of the mould providing better heat transfer have been proposed before. This paper deals with a new cooling system that follows the shape of the part in core and cavity. This alternative method uses a metallic mold with thin walls, to increase the heat absorption from the molten plastic and reduce thermal inertia, mounted in a chamber constructed from a thermo-insulating material. Between the active elements of the mold and the exterior chamber a heating/cooling fluid is circulating. This ensures quasi isothermal filling conditions and a uniform as well as a more efficient cooling process.
Identification of an Up-Stream Promoter of the Human Parathyroid Hormone-Related Peptide Gene (1990)

Previous evidence has suggested that the human PTH-related peptide (PTHRP) gene uses two promoters, one a short down-stream element lying immediately between two 5′ exons (1 and 2) and a second lying in an unknown up-stream location. We approached identification of the up-stream element in three steps. First, Northern analysis carried out using progressively 5′ fragments of the gene as probes identified a candidate region some 2.5 kilobases up-stream of exon 1. Second, a battery of overlapping 5′ cRNA probes was used in RNase protection experiments to identify two previously unrecognized exons, 212 and 93 basepairs in length (termed exons 1A and 1B to distinguish them from the previously designated exon 1, which was termed exon 1C). Third, primer extension experiments were performed with oligonucleotides complementary to each of the 5′ exonic sequences. These experiments identified a transcription start site up-stream of exon 1A and also demonstrated that the 5′ exons of the PTHRP gene could be spliced together in several combinations. The up-stream promoter element contains a TATA box, but does not otherwise resemble the down-stream PTHRP gene promoter or the PTH gene promoter. We conclude that the human PTHRP gene contains eight exons spanning more than 15 kilobases of genomic DNA, with promoter elements lying immediately up-stream of exons 1A and 2. The identification of these elements will permit functional analysis of their roles in mediating tissue- and tumor-specific PTHRP gene expression.
Constructing the Field (2003)

Ethnographic fieldwork is traditionally seen as what distinguishes social and cultural anthropology from the other social sciences. This collection responds to the inte nsifying scrutiny of fieldwork in recent years. It challenges the idea of the necessity for the total immersion of the ethnographer in the field, and for the clear separation of professional and personal areas of activity. The very existence of 'the field' as an entity separate from everyday life is questioned. Fresh perspectives on contemporary fieldwork are provided by diverse case-studies from across North America and Europe. These contributions give a thorough appraisal of what fieldwork is and should be, and an extra dimension is added through fascinating accounts of the personal experiences of anthropologists in the field.
Clinical heterogeneity of <i>ATP13A2</i> linked disease (Kufor-Rakeb) justifies a <i>PARK</i> designation (2007)

In this issue of Neurology , Di Fonzo and colleagues describe the identification of a Brazilian patient with juvenile parkinsonism who carries a homozygous missense mutation in ATP13A2 .1 Mutation of this gene has been recently shown to underlie the autosomal recessive, l-dopa–responsive, pallido-pyramidal disease Kufor-Rakeb syndrome (KRS).

KRS was originally described by Al Din and colleagues in 1994, when they reported the clinical and radiologic features of five siblings born of a consanguineous marriage and living with their parents in the small homestead of Kufor-Rakeb in Jordan.2 Onset occurred between the ages of 12 and 15 years with lethargy and bradyphrenia evolving over several months culminating in social withdrawal and removal from schooling. Difficulties with walking due to stiffness and postural abnormalities started at around the same time. Within 2 years of onset problems with swallowing and articulating had appeared and assistance was required in several everyday tasks. Cognitive decline continued with slowness of thinking, perseveration, and utilization behavior …
Growth of high quality epitaxial CdxHg1-xTe films by sputter deposition (1982)

Epitaxial CdxHg1-xTe films have been simultaneously grown onto several CdTe substrates (total area 20 cm 2) by cathodic sputtering in a mercury vapour plasma. The layers are grown on substrates heated up to 310°C with a deposition rate of 0.6μ/hour (total thickness ⩽ 30 μm). Crystallographic characterization has been carried out using different techniques such as: reflection X-ray topography, the measurement of the FWHM of the diffraction profile, transmission electron microscopy (TEM) and Rutherford back scattering (RBS). TEM, rocking curves and RBS results reveal a high crystallographic quality (dislocation density in the layer is approximately 104 cm-2). The Hall coefficient of CdxHg1-xTe epitaxial layers has been measured between 4 and 300 K. At 77 the results concerning layers deposited at 285°C (Cd composition of 0.23 and thickness of 16μm) are about n = 2.7 × 1016 cm-3 with a Hall mobility of 64000 cm2 V-1 s-1 and for a Cd composition of 0.31 (thickness of 18 μm) we obtainedn=1.6×1016 cm-3 and a Hall mobility of 16000 cm2 V-1 s-1. The film properties were improved by post deposition annealing in a Hg atmosphere using a two-zone furnace. An increase in electron mobility of n type films to values of those for bulk material were obtained using unoptimized annealing parameters.
Infarct Salvage With Liposomal Prostaglandin E <sub>1</sub> Administered by Intravenous Bolus Immediately Before Reperfusion in a Canine Infarction-Reperfusion Model (1995)

Bolus intravenous administration of TLC C-53 immediately before reperfusion results in reduced leukocyte infiltration and substantial infarct salvage. TLC C-53 mah be useful in limiting reperfusion injury during treatment of acute myocardial infarction.
Evidence for carbonyl sulfide (OCS) conversion to CO in the lower atmosphere of Venus (2009)

The chemical regimes in the atmosphere of Venus vary from photochemistry in the middle atmosphere to thermal equilibrium chemistry in the lower atmosphere and the surface. Many chemical cycles have been proposed, but few details about these cycles are fully verified by comparison between observations and modeling. Recent high‐quality data of carbonyl sulfide (OCS) and CO from ground‐based and Venus Express observations provide a unique opportunity to test our understanding of chemistry and transport in the lower atmosphere of Venus. The spatial distributions of OCS and CO in the atmosphere reflect a sensitive balance between chemistry and transport. On the basis of our updated photochemical model and winds from Lee et al.'s (2007) general circulation model, we study the chemistry and transport in a simplified two‐dimensional chemistry‐transport model. OCS is produced by heterogeneous reactions on the surface; the middle atmosphere is a net sink for OCS. The combination of data and modeling provides strong evidence for the loss of OCS by conversion to CO. The detailed chemical mechanism is currently unknown, although a number of speculations have been proposed. The sensitivity of the distributions of OCS and CO to model parameters is reported.
Oxazoles Are Masked Carboxyls That Activate Ortho-Leaving Groups in Nucleophilic Aromatic Substitution (1987)

Abstract Oxazoles substituted in their 2-positions with 2-methoxy-, 2-fluoro-, or 2,6-difluorophenyl groups, and in their 4,5-positions with methyls or phenyls, were treated with ArMgBr or ArLi to give substituted biphenyl or terphenyl products. The oxazole groups were subsequently converted to esters, acids, or amides. These reactions provide a new unsymmetrical aryl-aryl coupling synthon.
Analysis of the Luria–Delbrück distribution using discrete convolution powers (1992)

The Luria–Delbrück distribution arises in birth-and-mutation processes in population genetics that have been systematically studied for the last fifty years. The central result reported in this paper is a new recursion relation for computing this distribution which supersedes all past results in simplicity and computational efficiency: p 0 = e –m ; where m is the expected number of mutations. A new relation for the asymptotic behavior of p n (≈ c/n 2 ) is also derived. This corresponds to the probability of finding a very large number of mutants. A formula for the z- transform of the distribution is also reported.
Antenna Pattern Analysis and Measurements for Multiparameter Radars (1993)

Measuring the full polarization matrix using a research radar requires knowledge of the complex (i.e., amplitude and phase) antenna pattern to properly correct for bias errors in the measurements. However, generally only power patterns are available for analysis. Techniques are presented for obtaining bounds on the system differential reflectivity ZDR bias and the integrated cross-polarization ratio. A method for use of the phase shift between pulses to simultaneously estimate the differential phase and the radial velocity over the full Nyquist interval is described. NCAR's CP-2 10-cm antenna patterns with different horizontal and vertical polarization sidelobes were matched by rotating the feed support struts to be aligned on the diagonals so no preferential blockage occurred. The matched antenna patterns show much improved ZDR measurements in strong reflectivity gradients. The CP-2 3-cm antenna patterns were shown to be axially symmetric and typical of a well-designed, unblocked parabolic reflector.
S <scp>ee</scp> DB (2015)

Data analysts often build visualizations as the first step in their analytical workflow. However, when working with high-dimensional datasets, identifying visualizations that show relevant or desired trends in data can be laborious. We propose SeeDB, a visualization recommendation engine to facilitate fast visual analysis: given a subset of data to be studied, SeeDB intelligently explores the space of visualizations, evaluates promising visualizations for trends, and recommends those it deems most "useful" or "interesting". The two major obstacles in recommending interesting visualizations are (a) <i>scale</i>: evaluating a large number of candidate visualizations while responding within interactive time scales, and (b) <i>utility</i>: identifying an appropriate metric for assessing interestingness of visualizations. For the former, SeeDB introduces <i>pruning optimizations</i> to quickly identify high-utility visualizations and <i>sharing optimizations</i> to maximize sharing of computation across visualizations. For the latter, as a first step, we adopt a deviation-based metric for visualization utility, while indicating how we may be able to generalize it to other factors influencing utility. We implement SeeDB as a middleware layer that can run on top of any DBMS. Our experiments show that our framework can identify interesting visualizations with high accuracy. Our optimizations lead to <i>multiple orders of magnitude speedup</i> on relational row and column stores and provide recommendations at interactive time scales. Finally, we demonstrate via a user study the effectiveness of our deviation-based utility metric and the value of recommendations in supporting visual analytics.
Acetylation of Amikacin, a New Semisynthetic Antibiotic, by <i>Pseudomonas aeruginosa</i> Carrying an R Factor (1975)

A clinical isolate Pseudomonas aeruginosa GN315 resistant to amikacin (AK), a new semisynthetic antibiotic, inactivated AK by acetylation. The acetylating enzyme was purified approximately 146-fold from a crude extract of GN315 by affinity chromatography. Fractionated samples obtained by affinity chromatography showed almost the same inactivation curves toward 3',4'-dideoxykanamycin B (DKB) and AK. Partially purified AK-acetylating enzyme inactivated DKB and kanamycin A but could not inactivate gentamicin C(1). The optimal pH for their inactivation was 6.0 to 7.0, and the pH curves for the inactivation of both drugs were almost the same. These facts indicate that AK and DKB are inactivated by the same aminoglycoside-acetylating enzyme. Through elemental analysis, the inactivated AK was found to be a monoacetylated product of AK. A sample of inactivated AK was purified and compared with a synthetic 6'-N-acetyl AK by thin-layer chromatography, and the results indicated that AK was inactivated by acetylation of the 6'-NH(2) group. The ultraviolet, infrared, and nuclear magnetic resonance spectra of the inactivated AK showed that AK was inactivated by the enzyme through acetylation of the amino group of 6'-amino-6'-deoxy-d-glucose moiety of AK. This enzyme, mediated by R factor, is capable of conferring resistance to AK, DKB, kanamycin, gentamicin, and sulfanilamide.
Marked Response to Single Agent Trastuzumab in a Patient with Metastatic HER-2 Gene Amplified Rectal Cancer (2011)

Overexpression or HER-2 gene amplification occurs in approximately 25% of invasive breast cancers and predicts response to the targeting therapeutic antibody trastuzumab (1). In this report, trastuzumab was used in the treatment of a patient with metastatic colorectal cancer harboring HER-2 gene amplification and overexpression. There was a marked radiographic response to the trastuzumab. If a larger series confirms the efficacy of trastuzumab use in patients with colorectal cancers with HER-2 gene amplification, trastuzumab could help improve the outlook for patients with this unusual colorectal cancer variant.
Evaporation Coefficient of Liquids (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEvaporation Coefficient of LiquidsJer Ru MaaCite this: Ind. Eng. Chem. Fundamen. 1967, 6, 4, 504–518Publication Date (Print):November 1, 1967Publication History Published online1 May 2002Published inissue 1 November 1967https://pubs.acs.org/doi/10.1021/i160024a005https://doi.org/10.1021/i160024a005research-articleACS PublicationsRequest reuse permissionsArticle Views1195Altmetric-Citations84LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Synthesis of Polydopamine Nanoparticles for Drug Delivery Applications (2018)

For decades, pharmaceutical sciences have been using nanoparticles for drug delivery in order to reduce toxicity and side effects of drugs. Therefore, biodegradable and biocompatible nanocarrier is essential to deliver the drug within the therapeutic window [1]. A wide range of nanoparticles have been developed so far as carriers of drugs and other biomolecules such as liposomes, dendrimers, polymeric nanoparticles, mesoporous silica etc.[2] However, such nanocarriers required complicated procedures and instrumentation for their synthesis and fabrication. Herein, we have reported the synthesis of polydopamine nanoparticles (PDA NPs) by using a very simple procedure without involving harsh reaction conditions and complicated instrumentation.
A Novel Approach for Password Strength Analysis through Support Vector Machine (2013)

Abstract — Passwords are ubiquitous authentication methods and they represent the identity of an individual for a system. Users are consistently told that a strong password is essential these days to protect private data. Despite the existence of more secure methods of authenticating users, including smart cards and biometrics, password authentication continues to be the most common means in use. Thus it is important for organizations to recognize the vulnerabilities to which passwords are subjected, and develop strong policies governing the creation and use of passwords to ensure that those vulnerabilities are not exploited. This work employs machine Learning technique to analyze the strength of the password to facilitate organizations launch a multifaceted defense against password breach and provide a highly secure environment. A supervised learning algorithm namely Support Vector Machine is used for classification of password. The linear and nonlinear SVM classification models are trained using the features extracted from the password dataset. The trained model shows the prediction accuracy of about 98 % for 10fold cross validation.
Flagellin‐dependent <scp>TLR</scp>5/caveolin‐1 as a promising immune activator in immunosenescence (2015)

The age-associated decline of immune responses causes high susceptibility to infections and reduced vaccine efficacy in the elderly. However, the mechanisms underlying age-related deficits are unclear. Here, we found that the expression and signaling of flagellin (FlaB)-dependent Toll-like receptor 5 (TLR5), unlike the other TLRs, were well maintained in old macrophages, similar to young macrophages. The expression and activation of TLR5/MyD88, but not TLR4, were sensitively regulated by the upregulation of caveolin-1 in old macrophages through direct interaction. This interaction was also confirmed using macrophages from caveolin-1 or MyD88 knockout mice. Because TLR5 and caveolin-1 were well expressed in major old tissues including lung, skin, intestine, and spleen, we analyzed in vivo immune responses via a vaccine platform with FlaB as a mucosal adjuvant for the pneumococcal surface protein A (PspA) against Streptococcus pneumoniae infection in young and aged mice. The FlaB-PspA fusion protein induced a significantly higher level of PspA-specific IgG and IgA responses and demonstrated a high protective efficacy against a lethal challenge with live S. pneumoniae in aged mice. These results suggest that caveolin-1/TLR5 signaling plays a key role in age-associated innate immune responses and that FlaB-PspA stimulation of TLR5 may be a new strategy for a mucosal vaccine adjuvant against pneumococcal infection in the elderly.