gebhart/patrepeval huggingface dataset:
Using Visual Art Works As a Means for Improving Primary School Students’ Skills to Connected Speech (2015)

The article discusses problems of a child’s adaptation to school life and psychological features of first graders. teachersare advised on formingthe sustained cognitive interestin 7-year old children, developing the motivation to study, and creatingthe conditions for positive emotional attitude to school.
Elastographic versus x‐ray CT imaging of radio frequency ablation coagulations: An <i>in vitro</i> study (2004)

Techniques to image elasticity parameters (i.e., elastography) have recently become of great interest to researchers. In this paper we use conventional ultrasound elastography and x‐ray CT to image radio frequency (RF) ablation sites of excised canine liver enclosed in gelatin. Thermal coagulations of different sizes were produced by applying the RF procedure for various times and end point temperatures. Dimensions, areas and volumes computed from CT and elastography were compared with those on whole mount pathology specimens. Ultrasound elastography exhibited high contrast for the thermal coagulations and performed better than CT. The correlation between pathology and elastography for this sample set of 40 thermal coagulations for volume estimation, for area estimation) is better than the correlation between pathology and CT for volume estimation, for area estimation).
Switching characteristics of distributed Bragg reflector lasers (1992)

This paper presents numerical results concerning wavelength switching of multisection DBR lasers. The static tuning characteristics and the dynamic behavior of the switching between different longitudinal modes is investigated. The influence of hysteresis in the frequency versus grating current characteristics on the forward and backward switching time is clearly shown. The possibility of structures that can operate as frequency bistable devices is explored.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Increased expression of the transcription factors CCAAT-enhancer binding protein-? (C/EB?) and C/EBP? (CHOP) correlate with invasiveness of human colorectal cancer (2000)

Regulation of cell differentiation is most often impaired in malignant tumors and may represent a key mechanism for the progression of the disease. CCAAT-enhancer binding protein (C/EBP) is a family of transcription factors involved in the regulation of embryonic gut development in rodents, which has also been detected in various malignancies, e.g., liposarcomas and breast and ovarian epithelial tumors. We studied the relationship between C/EBP and tumor histology (Duke's invasive stage and pathological grade) in colorectal cancer. Immunoblotting techniques were used on microdissected fresh frozen tumor specimens, and expression of C/EBPalpha, C/EBPbeta and C/EBPzeta (CHOP) was analyzed in addition to that of the cell-cycle regulator p53 and the proliferation marker PCNA. Expression of C/EBPbeta (LAP isoforms) was markedly increased in all tumors compared with normal colon mucosa. Although the inter-patient variability was large, we found that LIP, the isoform of C/EBPbeta known to inhibit transcription, was expressed at higher levels in Duke's stage B tumors compared with Duke's stage A, whereas Duke's C tumors had the lowest LIP expression. A similar relationship was seen for CHOP. The cell-cycle regulator gene p53 was the only factor that clearly correlated with pathological grade: a decrease in p53 expression was demonstrated. Our data suggest that genetic and cellular events involving C/EBPbeta and CHOP are important for tumor invasion and that these events do not appear to be related to the pathological grade of the tumor.
Role of PTEN gene in progression of prostate cancer. (2007)

Patients with prostate cancer who had PTEN mutation had also a significantly greater GS, poorer prognosis, and higher rate of metastasis. However, this mutation cannot predict the prognosis and the GS is a more precise factor.
A porous metal–organic cage constructed from dirhodium paddle-wheels: synthesis, structure and catalysis (2015)

A porous metal–organic cage (MOC-Rh-<bold>1</bold>) with Rh–Rh bonds has been prepared, which can act as a heterogeneous catalyst and promote the intramolecular C–H amination of azides.
Carbon Isosteres of the 4-Aminopyridine Substructure of Chloroquine:  Effects on p<i>K</i><sub>a</sub>, Hematin Binding, Inhibition of Hemozoin Formation, and Parasite Growth (2003)

Unlike diprotic chloroquine (CQ), its two 4-aminoquinoline carbon isosteres (1, 2) are monoprotic at physiological pH. Compared to CQ, hematin binding affinity of 1 decreased 6.4-fold, and there was no measurable binding for 2. Although 1 was a weak inhibitor of hemozoin formation, neither isostere inhibited P. falciparum in vitro. Evidently, the CQ-hematin interaction is largely a function of its pyridine substructure, but inhibition of hemozoin formation and parasite growth depends on its 4-aminopyridine substructure.
Methods of Demonstrating Article and Journal Impact (2009)

Faculty members preparing their dossiers typically need to demonstrate the impact of that portion of their research that has appeared in the journal literature. This article describes several methods of demonstrating article and journal impact. An article's impact can be shown by counting the number of citations it has received and by comparing that total to the number of citations received by other articles in the same volume. Journal impact can be demonstrated using the journal impact factor computed by ISI Thomson Research or the journal's acceptance rate. Journal prestige can also be demonstrated with the use of published lists from various sources, including research studies in the literature. A sample article is used as a case study to illustrate each method.
Erratum: “Structural and electronic properties of Ga2O3-Al2O3 alloys” [Appl. Phys. Lett. <b>112</b>, 242101 (2018)] (2019)

First Page
Multilevel-Enabled Double-Density Writable and Rewritable Digital Versatile Disc System (2003)

Multilevel (ML) recording technology doubles the speed and capacity of standard digital versatile disc (DVD) writable and rewritable systems. Implemented with the addition of single chip or core to the standard drive architecture, ML technology doubles performance with no change to the optical mechanical unit. While custom media has been optimized for high speed ML recording, ML recording works well with standard writable and rewritable media.
An Investigation of Dynamic Modulus and Flow Number Properties of Asphalt Mixtures In Washington State (2011)

Pavement design is now moving toward more mechanistic based design methodologies for the purpose of producing long lasting and higher performance pavements in a cost-effective manner. The recent Mechanistic-Empirical pavement design guide (MEPDG) is a product under such direction and is making progresses in improving current design methods. Dynamic Modulus is proposed by the MEPDG as an important material characterization property and key input parameter which correlates material properties to field fatigue cracking and rutting performance. Washington State has strong background and has put many efforts in moving toward the M-E based design procedures. In addition, Washington State has developed comprehensive pavement management system (PMS) database which makes it possible to use local pavement performance data to calibrate design models and optimize pavement design. However, there is still one important thing missing in this implementation step, which is a comprehensive local material database. Given the limited resources (equipment and time), such database will help the designer to select material properties that are more applicable to local materials and thus develop more reasonable level III design. Therefore, the objectives of this study are to conduct dynamic modulus (E*) tests on asphalt mixtures most popularly used in the State of Washington under different climate conditions, generate material database for the implementation of MEPDG design procedure in Washington State, and provide an evaluation method for recommending potential performing mixes by correlating E* test results to field rutting performance using Washington State PMS data. Both lab prepared mixtures based on designs typically used in Western, Central, and Eastern Washington region, and field cored samples from representative field sites will be measured for dynamic modulus over a wide time-temperature domain. Results will be correlated to pavement performance, so that desirable material properties and E* values can be recommended for Washington material and climate conditions.
Isolation and characterization of spontaneously occurring TOL plasmid mutants of Pseudomonas putida HS1 (1981)

A strain of Pseudomonas (P. putida HS1) was found to resemble P. putida (arvilla) mt-2 in its ability to degrade toluene, m- and p-xylene, 1,2,4-trimethylbenzene (pseudocumene), and 3-ethyltoluene via oxidation of a methyl substituent and reactions of the meta-fission pathway. The ability to degrade these substrates by P. putida HS1 (PpC1) was shown to be encoded by a TOL (pDK1) plasmid as evidenced by: (i) spontaneous loss of the TOL-related phenotype after growth with benzoate, (ii) transfer of the TOL character from the wild type into cured recipients by conjugation, and (iii) isolation of a plasmid of identical molecular weight (120 X 10(6)) from both the wild type and an exconjugant obtained by mating wild type with a putative cured recipient. In addition to the isolation of apparent cured strains having lost the entire TOL-related phenotype, two additional mutant classes were observed after growth on benzoate. One class, represented by PpCT1, was unable to utilize the alkyl-substituted aromatic compounds but retained the ability to grow with toluene and benzyl alcohol. Analysis of PpCT1 revealed that it was unable to synthesize the TOL-encoded toluate oxidase and enzymes of the meta pathway but retained the ability to elaborate activities for toluene hydroxylase, benzyl alcohol, and benzaldehyde dehydrogenase, thereby mediating initial oxidation of toluene to benzoate, which was then further metabolized via enzymes of the chromosomally encoded ortho-fission pathway. A second class of mutants had lost the ability to utilize the hydrocarbons but could still grow with m-toluate but not p-toluate, 3,4-dimethylbenzoate, or 3-ethylbenzoate, intermediates in the oxidation of the corresponding hydrocarbons. Our such mutant, PpCM1, could no longer synthesize enzymes required for initial oxidation of the hydrocarbons, but was able to produce the toluate oxidase and enzymes of the meta pathway, thereby facilitating degradation of m-toluate. Neither PpCT1, PpCM1, nor a putative cured strain, PpCC1, reverted at detectable frequencies (less than 10(-9). Analysis of each strain for plasmid deoxyribonucleic acid revealed the presence of a single plasmid in each strain with the following molecular weights: PpCM1, 100 X 10(6) (pDKM1); PpCT1, 80 X 10(6) (pDKT1); PpCC1 20 X 10(6) (pDKC1). The results suggest that the TOL (pDK1) plasmid has undergone deletions giving rise to smaller replicons which either encode for only a fraction of the wild-type catabolic functions (pDKM1, pDKT1) or have lost all catabolic activities (pDKC1).
ETHYL BICYCLO[1.1.0]BUTANE-1-CARBOXYLATE<sup>1</sup> (1959)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTETHYL BICYCLO[1.1.0]BUTANE-1-CARBOXYLATE1Kenneth B. Wiberg and Richard P. CiulaCite this: J. Am. Chem. Soc. 1959, 81, 19, 5261–5262Publication Date (Print):October 1, 1959Publication History Published online1 May 2002Published inissue 1 October 1959https://pubs.acs.org/doi/10.1021/ja01528a060https://doi.org/10.1021/ja01528a060research-articleACS PublicationsRequest reuse permissionsArticle Views538Altmetric-Citations56LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The selective hydrogenation of acetylene (1958)

G. C. Bond, D. A. Dowden and N. Mackenzie, Trans. Faraday Soc., 1958, 54, 1537 DOI: 10.1039/TF9585401537
Microwave-assisted three-component coupling-addition-S<sub>N</sub>Ar (CASNAR) sequences to annelated 4H-thiopyran-4-ones (2009)

A whole family of annelated 4H-thiopyran-4-ones as the core structural unit was readily synthesized in good yields by a microwave-assisted coupling-addition-S(N)Ar (CASNAR) sequence starting from readily available (het)aroyl chlorides, alkynes and sodium sulfide nonahydrate in a consecutive one-pot three-component reaction. All representatives display a pronounced halochromicity of the absorption bands upon protonation. According to DFT calculations, the electronic ground state of the annelated 4H-thiopyran-4-ones possess a considerable zwitterionic character.
Atrial fibrillation detection algorithms for very long term ECG monitoring (2005)

In this paper, we describe two algorithms suitable for the detection of Atrial Fibrillation episodes in very long terms (weeks) ECG monitoring, were the need of onboard implementation requires the development of reliable but simple and easy-to-implement methods. The proposed algorithms are based on the extraction of simple geometric features from the histogram of RR prematurity and delta RR. On the MIT Atrial fibrillation database, the RR prematurity algorithm provides the following performances: episodes sensitivity (S) 91%, episode positive Predictivity (P+) 92%, duration S 93%, duration P+ 97%. For the delta-RR algorithm the results were: episodes S 92%, episode P+ 78%, duration S 89%, duration P+ 90%
Linkages between glucosaminoglycan and glucan determine alkali-insolubility of the glucan in walls of<i>Saccharomyces cerevisiae</i> (1987)

Glucosaminoglycans in the alkali-insoluble wall fraction of the yeast Saccharomyces cerevisiae could be partly degraded by treatment with nitrous acid, indicating the presence of non-acetylated glucosamine residues, and almost completely degraded by treatment with chitinase. The latter treatment, solubilising 95% of the glucosaminoglycan, converted 92% of the alkali-insoluble glucan in the complex into an alkali-soluble form. It is suggested that the small amount of alkali-insoluble glucosaminoglycan in the yeast cell wall (less than 2% of the dry weight) is covalently linked to the β-glucan (about 28% of the dry weight), keeping the latter in an alkali-insoluble form.
ATPase-Defective Derivatives of <i>Escherichia coli</i> DnaK That Behave Differently with Respect to ATP-Induced Conformational Change and Peptide Release (2001)

We have characterized the effects of the T199S, T199A, and K70A mutations on the biochemical activity and in vivo functioning of Escherichia coli DnaK. Threonine-199 is the site of autophosphorylation of DnaK, and the lysine residue of bovine Hsc70 corresponding to K70 of DnaK has been shown to be essential for the hydrolysis of ATP. The dnaK alleles T199A and K70A are completely unable, and the T199S allele is only partially able, to complement the defects of a DeltadnaK mutant. The ATPase activities of the DnaK T199A and DnaK K70A proteins are nearly abolished, while the ATPase activity of the DnaK T199S protein has a steady-state rate similar to that of wild-type DnaK. The DnaK T199S protein also retains approximately 13% of the autophosphorylation activity of wild-type DnaK, while the autophosphorylation activities of the T199A and K70A derivatives are completely abolished. All four DnaK proteins bind a model peptide substrate, and the wild-type, T199A, and T199S DnaK proteins release the peptide with similar kinetics upon the addition of ATP. The DnaK K70A protein, in contrast, does not release the peptide upon the addition of ATP. ATP induces a conformational change in the wild-type, T199A, and T199S DnaK proteins but not in the DnaK K70A protein. The T199A and K70A mutations both disrupt the ATPase activity of DnaK but have profoundly different effects on the ATP-induced conformational change and peptide release activities of DnaK, implying that the two mutations affect different steps in the functional cycle of DnaK. The DnaK T199S protein represents a new class of DnaK mutant, one which has near-normal levels of ATPase activity and undergoes an ATP-induced conformational change that results in the release of peptide but which is not able to fully complement loss of DnaK function in the cell.
Manganese Toxicity Complicating Parenteral Nutrition (2019)

Departments of 1Medicine and 2Pulmonary and Critical Care SUNY Upstate Medical University Syracuse, NY
Optical recordings of taste responses from fungiform papillae of mouse <i>in situ</i> (2001)

Single taste buds in mouse fungiform papillae consist of approximately 50 elongated cells (TBCs), where fewer than three TBCs have synaptic contacts with taste nerves. We investigated whether the non-innervated TBCs were chemosensitive using a voltage-sensitive dye, tetramethylrhodamine methyl ester (TMRM), under in situ optical recording conditions. Prior to the optical recordings, we investigated the magnitude and polarity of receptor potentials under in situ whole-cell clamp conditions. In response to 10 mM HCl, several TBCs were depolarized by approximately 25 mV and elicited action potentials, while other TBCs were hyperpolarized by approximately 12 mV. The TBCs eliciting hyperpolarizing receptor potentials also generated action potentials on electrical stimulation. A mixture of 100 mM NaCl, 10 mM HCl and 500 mM sucrose depolarized six TBCs and hyperpolarized another three TBCs out of 13 identified TBCs in a taste bud viewed by optical section. In an optical section of another taste bud, 1 M NaCl depolarized five TBCs and hyperpolarized another two TBCs out of 11 identified TBCs. The number of chemosensitive TBCs was much larger than the number of innervated TBCs in a taste bud, indicating the existence of chemosensitivity in non-innervated TBCs. There was a tendency for TBCs eliciting the same polarity of receptor potential to occur together in taste buds. We discuss the role of non-innervated TBCs in taste information processing.
Personalized authentication procedure for restricted web service access in mobile phones (2014)

Security as a condition is the degree of resistance to, or protection from harm. Securing gadgets in a way that is simple for the user to deploy yet, stringent enough to deny any malware intrusions onto the protected circle is investigated to find a balance between the extremes. Basically, the dominant approach on current control access is via password or PIN, but its flaw is being clearly documented. An application (to be incorporated in a mobile phone) that allows the user's gadget to be used as a Biometric Capture device in addition to serve as a Biometric Signature acquisition device for processing a multi-level authentication procedure to allow access to any specific Web Service of exclusive confidentiality is proposed. To evaluate the lucidness of the proposed procedure, a specific set of domain specifications to work on are chosen and the accuracy of the Biometric face Recognition carried out is evaluated along with the compatibility of the Application developed with different sample inputs. The results obtained are exemplary compared to the existing other devices to suit a larger section of the society through the Internet for improving the security.
SciN Is an Outer Membrane Lipoprotein Required for Type VI Secretion in Enteroaggregative<i>Escherichia coli</i> (2008)

Enteroaggregative Escherichia coli (EAEC) is a pathogen implicated in several infant diarrhea or diarrheal outbreaks in areas of endemicity. Although multiple genes involved in EAEC pathogenesis have been identified, the overall mechanism of virulence is not well understood. Recently, a novel secretion system, called type VI secretion (T6S) system (T6SS), has been identified in EAEC and most animal or plant gram-negative pathogens. T6SSs are multicomponent cell envelope machines responsible for the secretion of at least two putative substrates, Hcp and VgrG. In EAEC, two copies of T6S gene clusters, called sci-1 and sci-2, are present on the pheU pathogenicity island. In this study, we focused our work on the sci-1 gene cluster. The Sci-1 apparatus is probably composed of all, or a subset of, the 21 gene products encoded on the cluster. Among these subunits, some are shared by all T6SSs identified to date, including a ClpV-type AAA(+) ATPase (SciG) and an IcmF (SciS) and an IcmH (SciP) homologue, as well as a putative lipoprotein (SciN). In this study, we demonstrate that sciN is a critical gene necessary for T6S-dependent secretion of the Hcp-like SciD protein and for biofilm formation. We further show that SciN is a lipoprotein, as shown by the inhibition of its processing by globomycin and in vivo labeling with [(3)H]palmitic acid. SciN is tethered to the outer membrane and exposed in the periplasm. Sequestration of SciN at the inner membrane by targeting the +2 residue responsible for lipoprotein localization (Gly2Asp) fails to complement an sciN mutant for SciD secretion and biofilm formation. Together, these results support a model in which SciN is an outer membrane lipoprotein exposed in the periplasm and essential for the Sci-1 apparatus function.
Carnegie Mellon Online: Web-mediated education (2002)

Distributed education, Web-based instruction, virtual classes-these are all trends in applying technologies to education and learning. One effort at Carnegie Mellon to explore Technology Enhanced Learning (TEL) has been through a system known as Carnegie Mellon Online. Online provides a technical infrastructure to deliver materials to our students both on and off campus. It is designed to deliver educational content and assess student competence in support of courses across the University's curriculum. The focus has been large, core, academic courses. We have built a course-neutral, database-driven, student-centered infrastructure that supports both Web-based course delivery and course management. In addition to delivering conventional Web-based hypertext and other media, the system generates customized content (e.g., assessments, feedback) for each individual student and tracks the student through a course while enforcing course specific rules and policies (e.g., topic prerequisites, time and place constraints for exams). The system is designed to be scalable to handle large numbers of courses and students. We describe our work to date, including our pedagogical motivations and our technical approach. We conclude with a discussion of how our approach differs from other uses of the Web in education.