gebhart/patrepeval huggingface dataset:
Health Effects of Phenolic Compounds Found in Extra-Virgin Olive Oil, By-Products, and Leaf of Olea europaea L. (2019)

<i>Olea europaea</i> L. fruit is a peculiar vegetal matrix containing high levels of fatty acids (98-99% of the total weight of extra-virgin olive oil, EVOO) and low quantities (1-2%) of phenolics, phytosterols, tocopherols, and squalene. Among these minor components, phenolics are relevant molecules for human health. This review is focused on their beneficial activity, in particular of hydroxytyrosol (HT), oleuropein (OLE), oleocanthal (OLC), and lignans found in EVOO, olive oil by-products and leaves. Specifically, the cardioprotective properties of the Mediterranean diet (MD) related to olive oil consumption, and the biological activities of polyphenols recovered from olive oil by-products and leaves were described. Recent European projects such as EPIC (European Prospective Investigation into Cancer and Nutrition) and EPICOR (long-term follow-up of antithrombotic management patterns in acute coronary syndrome patients) have demonstrated the functional and preventive activities of EVOO showing the relation both between cancer and nutrition and between consumption of EVOO, vegetables, and fruit and the incidence of coronary heart disease. The data reported in this review demonstrate that EVOO, one of the pillars of the MD, is the main product of <i>Olea europaea</i> L. fruits; leaves and by-products are secondary but precious products from which bioactive compounds can be recovered by green technologies and reused for food, agronomic, nutraceutical, and biomedical applications according to the circular economy strategy.
Recent Advancement on the Optical Properties of Two-Dimensional Molybdenum Disulfide (MoS2) Thin Films (2015)

The emergence of two-dimensional (2D) materials has led to tremendous interest in the study of graphene and a series of mono- and few-layered transition metal dichalcogenides (TMDCs). Among these TMDCs, the study of molybdenum disulfide (MoS2) has gained increasing attention due to its promising optical, electronic, and optoelectronic properties. Of particular interest is the indirect to direct band-gap transition from bulk and few-layered structures to mono-layered MoS2, respectively. In this review, the study of these properties is summarized. The use of Raman and Photoluminescence (PL) spectroscopy of MoS2 has become a reliable technique for differentiating the number of molecular layers in 2D MoS2.
Handbook on Theoretical and Algorithmic Aspects of Sensor, Ad Hoc Wireless, and Peer-to-Peer Networks (2005)

Popularized by Napster, peer-to-peer (P2P) has become a well-known term recently. Large amounts of files are shared in these P2P systems, such as Gnutella, KaZaA, and BitTorrent, with most of the contents being provided by the P2P users themselves. Today, millions of users (peers) join the network by connecting to some of the active peers in the P2P overlay network. © 2005 by Taylor & Francis Group, LLC.
Economy in Lower Gear through 2008 (2008)

According to participants in the Chicago Fed's annual Automotive Outlook Symposium, the nation's economic growth in 2008 is forecasted to be slower than in 2007, with inflation staying high and the unemployment rate rising. Light vehicle sales are predicted to fall sharply this year and then improve in 2009.
Talent Over Structure (2013)

Chapter 5 will focus on three issues to get the right leadership at the top. The need for a strategic selection of the CEO and the top team Focusing on talent over structures Getting the cultural fit right.
N-colour separation methods for accurate reproduction of spot colours (2015)

In packaging, spot colours are used to print key information like brand logos and elements for which the colour accuracy is critical. The present study investigates methods to aid the accurate reproduction of these spot colours with the n-colour printing process. Typical n-colour printing systems consist of supplementary inks in addition to the usual CMYK inks. Adding these inks to the traditional CMYK set increases the attainable colour gamut, but the added complexity creates several challenges in generating suitable colour separations for rendering colour images. \n\nIn this project, the n-colour separation is achieved by the use of additional sectors for intermediate inks. Each sector contains four inks with the achromatic ink (black) common to all sectors. This allows the extension of the principles of the CMYK printing process to these additional sectors. The methods developed in this study can be generalised to any number of inks. The project explores various aspects of the n-colour printing process including the forward characterisation methods, gamut prediction of the n-colour process and the inverse characterisation to calculate the n-colour separation for target spot colours. The scope of the study covers different printing technologies including lithographic offset, flexographic, thermal sublimation and inkjet printing. \n\nA new method is proposed to characterise the printing devices. This method, the spot colour overprint (SCOP) model, was evaluated for the n-colour printing process with different printing technologies. In addition, a set of real-world spot colours were converted to n-colour separations and printed with the 7-colour printing process to evaluate against the original spot colours. The results show that the proposed methods can be effectively used to replace the spot coloured inks with the n-colour printing process. This can save significant material, time and costs in the packaging industry.
Synergistic anti-methicillin-resistant Staphylococcus aureus (MRSA) activity and absolute stereochemistry of 7,8-dideoxygriseorhodin C (2020)

The emergence of antibiotic resistance necessitates not only the identification of new compounds with antimicrobial properties, but also new strategies and combination therapies to circumvent this growing problem. Here, we report synergistic activity against methicillin-resistant Staphylococcus aureus (MRSA) of the β-lactam antibiotic oxacillin combined with 7,8-dideoxygriseorhodin C in vitro. Ongoing efforts to identify antibiotics from marine mollusk-associated bacteria resulted in the isolation of 7,8-dideoxygriseorhodin C from a Streptomyces sp. strain cultivated from a marine gastropod tissue homogenate. Despite the long history of 7,8-dideoxygriseorhodin C in the literature, the absolute configuration has never been previously reported. A comparison of measured and calculated ECD spectra resolved the configuration of the spiroketal carbon C6, and 2D ROESY NMR spectroscopy established the absolute configuration as 6s,6aS. The compound is selective against Gram-positive bacteria including MRSA and Enterococcus faecium with an MIC range of 0.125-0.5 μg ml<sup>-1</sup>. Moreover, the compound synergizes with oxacillin against MRSA as observed in the antimicrobial microdilution and time-kill assays. Simultaneous treatment of the compound with oxacillin resulted in an approximately tenfold decrease in MIC with a combination index of <0.5, indicating synergistic anti-MRSA activity.
First Person Experience of Body Transfer in Virtual Reality (2010)

The results support the notion that bottom-up perceptual mechanisms can temporarily override top down knowledge resulting in a radical illusion of transfer of body ownership. The research also illustrates immersive virtual reality as a powerful tool in the study of body representation and experience, since it supports experimental manipulations that would otherwise be infeasible, with the technology being mature enough to represent human bodies and their motion.
Colorful Hydrophobic Poly(Vinyl Butyral)/Cationic Dye Fibrous Membranes via a Colored Solution Electrospinning Process (2016)

Colorful nanofibrous membranes have attracted much attention for their visual varieties and various functionalities. In this article, a colored solution electrospinning process was used to fabricate colorful hydrophobic poly(vinyl butyral) (PVB)/cationic dye nanofibrous membranes (NFMs) successfully. The color and morphology of these as-spun nanofibrous membranes have been analyzed by colorimetry, spectroscopy, and scanning electron microscopy (SEM). It is shown that the as-spun colorful PVB-based membranes exhibit excellent level-dyeing property and color stability. Furthermore, the doping of cationic dye and the increase of dye concentration can decrease the diameter of the as-spun colored fibers, which results in better level-dyeing property and higher water contact angle more than 140°. The stained PVB fibrous membranes with excellent level-dyeing property and hydrophobicity are promising in some applications such as textiles, wallpapers, and anticorrosive coating/painting.
Changes in the proportions of histone H1° subtypes in brain cortical neurons (1987)

Histone H1(0) is found in tissues with little or no cellular proliferation and has been shown to accumulate during cellular terminal differentiation. Two subtypes of H1(0), H1 a and H1 b, are present in any tissue where the protein has been detected. We report here the first evidence of an age-dependent change in the proportions of H1 subtypes. In rat cerebral cortex neurons the proportion of H1 a rises from 44% of total H1 at birth to about 80% at day 300. These results show that terminally differentiated neurons synthesize and exchange H1 at a significant rate.
Adaptive space-time coding system in fading channels (2002)

Recently, there has been increasing interest in providing high quality and efficient broadband services over wireless and mobile links. One powerful performance enhancing technique, which holds the promise of offering a significant increase in the system information capacity, is the adaptive antenna array. Space-time codes (STC) are designed to exploit multi-input and multi-output (MIMO) antenna systems and by doing so an enormous increase in the capacity of wireless systems can be achieved. In this paper, an adaptive space-time coding (ASTC) technique, which combines STC together with singular value decomposition (SVD), is designed to improve the performance of STC when the channel state information (CSI) is available at the transmitter. To demonstrate the potential of the proposed scheme, simulation results are presented and are compared with conventional STC. In particular, the proposed system sensitivity to channel estimation errors at the transmitter is thoroughly investigated.
Modelling and test results of the Archimedes wave swing (2006)

The objective of this paper is to describe the modelling and some of the offshore test results of the full-scale model of Archimedes wave swing (AWS) at Portugal in 2004. The AWS is a system that converts ocean wave energy into electric energy. A pilot plant of this system has been built. The paper starts with the derivation of a model for the floater motion. Next, the generator system is described and modelled. The generator system consists of a permanent-magnet linear synchronous generator with a current source inverter. Subsequently, test results are presented to validate the models for the floater motion and the generator. Finally, some conclusions are drawn.
A Sequential Ensemble Kalman Filter for Atmospheric Data Assimilation (2001)

An ensemble Kalman filter may be considered for the 4D assimilation of atmospheric data. In this paper, an efficient implementation of the analysis step of the filter is proposed. It employs a Schur (elementwise) product of the covariances of the background error calculated from the ensemble and a correlation function having local support to filter the small (and noisy) background-error covariances associated with remote observations. To solve the Kalman filter equations, the observations are organized into batches that are assimilated sequentially. For each batch, a Cholesky decomposition method is used to solve the system of linear equations. The ensemble of background fields is updated at each step of the sequential algorithm and, as more and more batches of observations are assimilated, evolves to eventually become the ensemble of analysis fields.
Antisense inhibition of <i>Engrailed</i> genes in mouse embryos reveals roles for these genes in craniofacial and neural tube development (1995)

The roles of engrailed-1 (En-1) and engrailed-2 (En-2) have been investigated during gastrulation and neurulation in mouse embryos. Using antisense oligonucleotides and murine whole embryo culture, early somite embryos were injected with antisense phosphorothioated oligonucleotides directed against En-1 or En-2 transcripts and then grown in vitro for 48 hr. Inhibition of En-1 by antisense targeting during this period resulted in embryos with craniofacial abnormalities, specifically loss of mid- and hindbrain tissue and hypoplasia in associated neural crest derived areas such as the face and first and second pharyngeal arches. In addition, En-1 appeared to be essential in early patterning of the neural tube. Embryos removed from culture as early as 8 hr following injection exhibited undulations in the presumptive spinal cord. Histological analysis of the affected neural tubes at 48 hr showed disrupted cytoarchitecture and in some cases, apparent dorsal-ventral duplication of the neural tube and underlying notochord. Using S100 beta as a notochord marker, embryos removed from culture at 8 or 12 hr following injection exhibited loss of S100 beta expression in the notochord region subjacent to affected neural tube segments, suggesting that S100 beta, or other notochordal genes, may be downstream components of the En-1 regulatory cascade. Furthermore, antisense inhibition of En-1 induced caudal dysgenesis, suggesting disruption in primitive streak function. Antisense targeting of En-2 expression of early somite stages produced few alterations in development, although approximately one third of the embryos exhibited a series of lateral folds in the spinal cord at the level of the forelimb-bud.(ABSTRACT TRUNCATED AT 250 WORDS)
The linguistics of punctuation (1990)

1. Introduction: in search of the written language 2. English punctuation: the limitations of contrastive approaches 3. The grammar of text-categories 4. The syntax of text-categories 5. Presentation of text-category indicators 6. The functions of text-categories 7. Conclusion Reference index.
Sorting Nexin 1 Down-Regulation Promotes Colon Tumorigenesis (2006)

These data suggest that loss of SNX1 may play a significant role in the development and aggressiveness of human colon cancer, at least partially through the mechanism of increased signaling from endosomes. Further, these findings suggest that dysregulation of endocytic proteins may represent a new paradigm in the process of carcinogenesis.
TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth (2021)

TNK1 is a non-receptor tyrosine kinase with poorly understood biological function and regulation. Here, we identify TNK1 dependencies in primary human cancers. We also discover a MARK-mediated phosphorylation on TNK1 at S502 that promotes an interaction between TNK1 and 14-3-3, which sequesters TNK1 and inhibits its kinase activity. Conversely, the release of TNK1 from 14-3-3 allows TNK1 to cluster in ubiquitin-rich puncta and become active. Active TNK1 induces growth factor-independent proliferation of lymphoid cells in cell culture and mouse models. One unusual feature of TNK1 is a ubiquitin-association domain (UBA) on its C-terminus. Here, we characterize the TNK1 UBA, which has high affinity for poly-ubiquitin. Point mutations that disrupt ubiquitin binding inhibit TNK1 activity. These data suggest a mechanism in which TNK1 toggles between 14-3-3-bound (inactive) and ubiquitin-bound (active) states. Finally, we identify a TNK1 inhibitor, TP-5801, which shows nanomolar potency against TNK1-transformed cells and suppresses tumor growth in vivo.
Polarization-Independent Coherent Real-Time Analog Receiver for PON Access Systems (2016)

A 1.25-Gb/s ASK passive optical network (PON) system with a -51 dBm pre-FEC sensitivity (at BER = 2 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-3</sup> ) is enabled by a real-time polarization-independent coherent receiver (PI-RX) that needs no DSP (nor ADC). The receiver, which only makes use of common DFBs and commercially available electronic ICs, is targeted for use on a 6.25-GHz UD-WDM grid and has a 52-dB dynamic range. Measurements of the robustness of the PI-RX against backreflections and crosstalk from coexistent adjacent channels show that this preliminary implementation is suitable for UD-WDM-PON systems with frequency spacing down to 5 GHz.
Self-adaptive neural architectures for control applications (1990)

The potential use of the modeling capacity of neural networks for control applications is examined. A neuromorphic controller, called the self-adaptive neural controller (SANC), is designed by utilizing the neural modeling capacity. The results of this approach reveal at least two expected benefits: learning from example and dynamical adaptation. With the learning from example ability, SANC is essentially application-independent, even if the plant considered is too complex or too uncertain to be modeled by precise mathematical expressions. With the dynamical adaptation feature, SANC is shown to be robust, adaptive. and capable of learning, even if the environment varies too much to be controlled by traditional controllers
Immobilization of oriented protein molecules on poly(ethylene glycol)‐coated Si(111) (2004)

A high-density poly(ethylene glycol) (PEG)-coated Si(111) surface is used for the immobilization of polyhistidine-tagged protein molecules. This process features a number of properties that are highly desirable for protein microarray technology: (i) minimal nonspecific protein adsorption; (ii) highly uniform surface functionality; (iii) controlled protein orientation; and (iv) highly specific immobilization reaction without the need of protein purification. The high-density PEG-coated silicon surface is obtained from the reaction of a multi-arm PEG (mPEG) molecule with a chlorine terminated Si(111) surface to give a mPEG film with thickness of 5.2 nm. Four out of the eight arms on each immobilized mPEG molecule are accessible for linking to the chelating iminodiacetic acid (IDA) groups for the binding of Cu(2+) ions. The resulting Cu(2+)-IDA-mPEG-Si(111) surface is shown to specifically bind 6x histidine-tagged protein molecules, including green fluorescent protein (GFP) and sulfotransferase (ST), but otherwise retains its inertness towards nonspecific protein adsorption. We demonstrate a particular advantage of this strategy: the possibility of protein immobilization without the need of prepurification. Surface concentrations of relevant chemical species are quantitatively characterized at each reaction step by X-ray photoelectron spectroscopy (XPS). This kind of quantitative analysis is essential in tuning surface concentration and chemical environment for optimal sensitivity in probe-target interaction.
A systematic numerical study of Fourier gratings (1982)

A systematic numerical study of the efficiency of perfectly conducting Fourier gratings is presented. Efficiency curves for optimized Fourier gratings in Littrow mount are given and compared to those of the corresponding sinusoidal and echelette gratings. It is shown that under certain circumstances the former are better. The influence of finite conductivity as well as non-zero deviation is discussed.
Enthalpie et entropie de fusion du polystyrolène isotactique (1959)

L'enthalpie ΔHu et l'entropie ΔSu de fusion du polystyrolene isotactique ont ete determinees a partir de mesures d'abaissements de la temperature de fusion que presente un echantillon donne quand on lui additionne des quantites variables d'un diluant. Les mesures faites avec la benzophenone et le phenanthrene conduisent aux resultats suivants: 






Les mesures montrent egalement que les deux diluants choisis sont de tres bons solvants pour le polystyrolene.



Le degre de cristallinite de l'echantillon de polystyrolene isotactique utilise pour ces mesures est de l'ordre de 22,5%.
A model-driven environment for component deployment (2005)

This paper presents deployment factory, a model-driven unified environment for deploying component-based applications. While there are projects aiming to develop a unified deployment environment for component-based applications, none of them is generic enough - they do not support heterogeneous applications, they are targeted for a single component technology and/or impose modifications of the underlying technologies. The deployment factory targets all these issues. It is based on (i) the OMG deployment and configuration specification, (ii) an analysis of contemporary used component technologies, and (iii) our experience from component-based development. Moreover, the paper also shows that a plain MDA approach (the one used in the OMG deployment and configuration specification) for building real systems is not always appropriate.
Neuroimmunological Mechanism of Pruritus in Atopic Dermatitis Focused on the Role of Serotonin (2012)

Although pruritus is the critical symptom of atopic dermatitis that profoundly affect the patients' quality of life, controlling and management of prurirtus still remains as unmet needs mainly due to the distinctive multifactorial pathogenesis of pruritus in atopic dermatitis. Based on the distinct feature of atopic dermatitis that psychological state of patients substantially influence on the intensity of pruritus, various psychotropic drugs have been used in clinic to relieve pruritus of atopic dermatitis patients. Only several psychotropic drugs were reported to show real antipruritic effects in atopic dermatitis patients including naltrexone, doxepin, trimipramine, bupropion, tandospirone, paroxetine and fluvoxamine. However, the precise mechanisms of antipruritic effect of these psychotropic drugs are still unclear. In human skin, serotonin receptors and serotonin transporter protein are expressed on skin cells such as keratinocytes, melanocytes, dermal fibroblasts, mast cells, T cells, natural killer cells, langerhans cells, and sensory nerve endings. It is noteworthy that serotonergic drugs, as well as serotonin itself, showed immune-modulating effect. Fenfluramine, fluoxetine and 2, 5-dimethoxy-4-iodoamphetamine significantly decreased lymphocyte proliferation. It is still questionable whether these serotonergic drugs exert the immunosuppressive effects via serotonin receptor or serotonin transporter. All these clinical and experimental reports suggest the possibility that antipruritic effects of selective serotonin reuptake inhibitors in atopic dermatitis patients might be at least partly due to their suppressive effect on T cells. Further studies should be conducted to elucidate the precise mechanism of neuroimmunological interaction in pruritus of atopic dermatitis.