gebhart/patrepeval huggingface dataset:
Annexin 1 and its bioactive peptide inhibit neutrophil-endothelium interactions under flow: indication of distinct receptor involvement (2005)

We have tested the effects of annexin 1 (ANXA1) and its N-terminal peptide Ac2-26 on polymorphonuclear leukocyte (PMN) recruitment under flow. Differential effects of the full-length protein and its peptide were observed; ANXA1 inhibited firm adhesion of human PMNs, while Ac2-26 significantly attenuated capture and rolling without effect on firm adhesion. Analysis of the effects of ANXA1 and Ac2-26 on PMN adhesion molecule expression supported the flow chamber results, with Ac2-26 but not ANXA1 causing l-selectin and PSGL-1 shedding. ANXA1 and its peptide act via the FPR family of receptors. This was corroborated using HEK-293 cells transfected with FPR or FPRL-1/ALX (the 2 members of this family expressed by human PMNs). While Ac2-26 bound both FPR and FPRL-1/ALX, ANXA1 bound FPRL-1/ALX only. ANXA1 and Ac2-26 acted as genuine agonists; Ac2-26 binding led to ERK activation in both FPR- and FPRL-1/ALX-transfected cells, while ANXA1 caused ERK activation only in cells transfected with FPRL-1/ALX. Finally, blockade of FPRL-1/ALX with a neutralizing monoclonal antibody was found to abrogate the effects of ANXA1 in the flow chamber but was without effect on Ac2-26-mediated inhibition of rolling. These findings demonstrate for the first time distinct mechanisms of action for ANXA1 and its N-terminal peptide Ac2-26.
Stereoselective One-Pot Synthesis of Oxazolines (2008)

Treatment of alkenes with NBS, a nitrile, NaHCO3 and water in the presence of Cu(OTf)2 or Zn(OTf)2 is reported to furnish oxazolines in one pot and good yields. The reaction is equally applicable to chalcones.
Finding Common Ground (2017)

For more than two decades, capacitive sensing has played a prominent role in human-computer interaction research. Capacitive sensing has become ubiquitous on mobile, wearable, and stationary devices - enabling fundamentally new interaction techniques on, above, and around them. The research community has also enabled human position estimation and whole-body gestural interaction in instrumented environments. However, the broad field of capacitive sensing research has become fragmented by different approaches and terminology used across the various domains. This paper strives to unify the field by advocating consistent terminology and proposing a new taxonomy to classify capacitive sensing approaches. Our extensive survey provides an analysis and review of past research and identifies challenges for future work. We aim to create a common understanding within the field of human-computer interaction, for researchers and practitioners alike, and to stimulate and facilitate future research in capacitive sensing.
Discrimination between different E-box-binding proteins at an endogenous target gene of c-myc. (1996)

c-myc plans a key role in regulating mammalian cell proliferation and apoptosis. The gene codes for a transcription factor, Myc, that belongs to the helix-loop-helix/leucine zipper (HLH/LZ) family of proteins. Myc heterodimerizes with a partner protein termed Max; the heterodimeric complex binds to CAC(G/A)TG (E-box) sequences and activates transcription from these sites. However, several other HLH/LZ proteins, including USF and TFE-3, bind to and trans-activate from the same element, yet have no documented effect on cell proliferation or apoptosis. Therefore, it is likely that mechanisms exist that discriminate between these proteins for activation of natural target genes of Myc. We now show that trans-activation from the E-box in the rat prothymosin-alpha intron enhancer is indeed specific for Myc, and identify both the distance from the start site of transcription and a second E-box element adjacent to that recognized by Myc as critical determinants of specificity. Surprisingly, transcription activation domains required for Myc to activate from this distal enhancer position differ from previously mapped domains and closely correlate with those domains essential for transformation. As observed in transformation assays, Myc and Max strongly synergize in activation from a distal enhancer position. Our data suggest that trans-activation from the prothymosin intron enhancer is a faithful reflection of the transforming properties of the Myc protein.
Biochemical Changes Associated with Zygotic Pine Embryo Development (1987)

Johnson, M. A., Carlson, J. A., Conkey, J. H. and Noland, T. L. 1987. Biochemical changes associated with zygotic pine embryo development.—J. exp. Bot. 38: 518–524. At intervals during the period from pre-fertilization to near maturation, pine (Pinus resinosa Ait. and Pinus strobus L.) ovules were analysed for several biochemical constituents, and the results were expressed on a fresh weight basis. Lipid accumulated in parallel with the growth of the developing seeds. Soluble protein also accumulated but only in the initial stages of development. ATP content peaked approximately 2 weeks after fertilization, followed about one week later by the energy charge; these peaks were associated with maximal growth stages of the developing embryos. Likewise, peaks of glutathione (GSH) and ascorbic acid (AA), two water-soluble reductants, preceded or coincided with the ATP maximum. At late stages of seed development, dissection of the more mature ovules into embryos and gametophytes for analysis revealed that the ATP, GSH, and AA were more concentrated in the embryonic tissue. On the other hand, this segregation showed that virtually no proanthocyanidin was located in the developing embryos proper, although they contained other reductants, some of which were probably phenolics. Also, general staining with reagents for phenolics and thiols indicated that the former occurred primarily in non-embryonic tissue, whereas GSH was in the embryo per se. These findings are consistent with roles for ATP, GSH, and AA in the growth and development of zygotic pine embryos; however, it would appear that lipid and protein are being stored for subsequent germination events and that much of the phenolic component is segregated from the developing embryo.
Speech Perception Without Traditional Speech Cues (1981)

A three-tone sinusoidal replica of a naturally produced utterance was identified by listeners, despite the readily apparent unnatural speech quality of the signal. The time-varying properties of these highly artificial acoustic signals are apparently sufficient to support perception of the linguistic message in the absence of traditional acoustic cues for phonetic segments.
Knee Trauma (2019)

Chapter 21 reviews the mechanism of injury and clinical features, imaging strategy, imaging characteristics, and treatment options of knee trauma, including tibial plateau fractures with description of the Schatzker classification, knee dislocation, patellar fractures, and avulsion fractures about the knee. Associated vascular injury with knee dislocation and certain tibial plateau fractures are also discussed. Concomitant ligamentous and meniscal injuries associated with avulsion fractures are described. Oblique radiographs are helpful for detecting tibial plateau fractures. CT is useful in quantifying the degree of depression in tibial plateau fractures. Certain avulsion fractures and signs about the knee are often associated with significant ligamentous injury and should be evaluated with MRI.
Nanoprecision algorithm for surface plasmon resonance determination from images with low contrast for improved sensor resolution (2011)

A forward-projection algorithm based on Radon transform for two-dimensional surface plasmon imaging was devised to achieve nanoscale precision in determining the surface plasmon signal. A diverging laser beam at the chosen frequency was used to overcome the angular scanning in the well-known Kretschmann configuration. Multichannel sensing with improved resolution was realized. The technique was also used to find the lateral resolution of the sensor using a patterned layer of 40-nm thick SiO2 layer on top of the metallic surface. As a surface plasmon resonance signal detector, the use of the proposed Radon transform algorithm shows nanoprecision accuracy in cases of single and multichannel sensing. The method also provides the filtered output of the signal without any extra modification and therefore, it is nonsensitive to noise.
Detection of Peri-Synaptic Amyloid-β Pyroglutamate Aggregates in Early Stages of Alzheimer's Disease and in AβPP Transgenic Mice Using a Novel Monoclonal Antibody (2012)

The neurodegenerative pathology in patients with Alzheimer's disease (AD) has been associated with the progressive accumulation of aggregated and post-translationally modified amyloid-β (Aβ) species. Among them, recent studies indicate that the pyroglutamate modification of Aβ (pE(3)Aβ) catalyzed by glutaminyl cyclase might play an important role in the pathogenesis of AD. Although the effects of the pyroglutamate modification on Aβ aggregation and toxicity have been investigated, less is known about the distribution of pE(3)Aβ across the spectrum of AD and in the brains of amyloid-β protein precursor (AβPP) transgenic (tg) animals. For this purpose, we generated a novel monoclonal antibody (denominated D129) that specifically recognizes pE(3)Aβ and characterized the patterns of distribution in the postmortem brain samples from AD patients divided by disease stage (Braak stage) and in AβPP tg mice. We found that in early stages of AD and young AβPP tg mice pE(3)Aβ was found in discrete linear and granular aggregates in the neuropil that co-localized with the pre-synaptic protein synaptophysin and was in close opposition to dendrites labeled with MAP2. In later stages of AD and in older AβPP tg mice, pE(3)Aβ was abundant in diffuse and mature plaques. In conclusion, this study suggests that peri-synaptic accumulation of pE(3)Aβ might contribute to early cognitive dysfunction in AD.
The Effect of Enzyme Supplementation on the Apparent Metabolizable Energy and Nutrient Digestibilities of Wheat, Barley, Oats, and Rye for the Young Broiler Chick (1992)

The influence of enzyme supplementation on the bioavailable energy (AME(n)) and apparent digestibilities of lipid (ALD) and protein (APD) in young broiler chicks was examined for diets containing either wheat, hulled or hulless barley, naked oats, or spring rye. Dietary AME(n), APD, and ALD values were depressed (P less than or equal to .01) for all test grains (except hulled Bedford barley) as the inclusion rate of the grain replacing wheat increased. The antinutritives, beta-glucans (barley and oats) and pentosans (rye), had the most pronounced effect on ALD. The decreases in ALD were 43, 77, and 67% for chicks fed diets containing 70% Scout barley (hulless), Terra oats, and Gazelle rye, respectively, compared with those fed the control wheat diet. Enzyme supplementation increased (P less than or equal to .01) AME(n), APD, and ALD for all test cereals. The corresponding increases in the AME(n), of the enzyme-supplemented diets containing 70% HY320 wheat, Bedford barley, Scout barley, Terra oats, and Gazelle rye diets were 4, 7, 42, 33, and 14%, respectively, compared with their unsupplemented counterparts. Enzyme treatment also improved (P less than or equal to .01) weight gains and feed conversion efficiencies of chicks fed diets containing each of the cereals. Overall, the results demonstrate that the nutritive value of cereal grains such as wheat, barley, oats, and rye can be improved by the addition of crude fungal extracts to the diet of young chicks.
Development of 1600 N/mm2 Class Ultra-High Strength Bolts (2003)

<span class="label">1</span> <div class="htmlview paragraph">Many different bolts are employed in automobiles for different purposes and uses, and their strength generally ranges from 700 N/mm<sup>2</sup> to 1200 N/mm<sup>2</sup>. Automobiles face the issue of making improvements in fuel economy as an environmental measure, and there is consequently a requirement to lighten component parts. The creationof higher-strength bolts is an important factor in achieving lighter weight. Increasing the strength, however, can also bring about an increased incidence of delayed fracture, and the conventional solution used to require the application of special steels such as expensive maraging steel. The present development addressed this issue by focusing on high carbon steel rod, which had been considered less susceptible to delayed fracture, although heading was also considered to be difficult. Heading techniques were therefore devised that made it possible not only to form bolts from this material, but also to provide satisfactory strength. The result was successful development of 1600 N/mm<sup>2</sup> class high strength bolts.</div>
Reanalysis of Forensic Urine Specimens Containing Benzoylecgonine and THC-COOH (1994)

Drug testing laboratories are often requested to retest specimens that have tested positive. The reproducibility of analytical retest data for delta-9-tetrahydrocannabinol-9-carboxylic acid (THC-COOH) and benzoylecgonine in specimens that had previously been analyzed and then frozen by the Navy Drug Screening Laboratory, Great Lakes is examined in this study. All specimens were tested by gas chromatography/mass spectrometry (GC/MS). Retest values generally showed a decrease in concentration but exhibited considerable variability. Eighty-five THC-COOH positive urine specimens stored frozen for 1 to 10 months (average 2.3 months) declined an average of 25% (range, +30% to -80%) and 61 benzoylecgonine positive urine specimens stored for 1 to 8 months (average 2.3 months) declined an average of 19% (ranged +20% to -100%) from initial GC/MS test results. Drugs were found to partition into strata when frozen in urine because of the thermodynamics of the freezing process. To assure a homogenous solution for repeat testing, specimens that have been frozen and thawed were gently mixed before analysis.
Cloning of large DNA fragments, which hybridize with actinorhodin biosynthesis genes, from kalafungin and nanaomycin a methyl ester producers and identification of genes for kalafungin biosynthesis of the kalafungin producer. (1991)

Large actI, III-homologous DNA fragments were isolated from genomic libraries of the strains that produce the benzoisochromanequinone antibiotics kalafungin and nanaomycin A methyl ester, Streptomyces tanashiensis strain Kala and Streptomyces sp. OM-173, respectively. These libraries were prepared in Escherichia coli JM108 by using a novel Streptomyces-E. coli bifunctional cosmid, pKU205, and screened with polyketide synthase genes (actI and III) for actinorhodin biosynthesis from Streptomyces coelicolor A3(2) as probes. The cloned DNA fragments (28 and 42 kb) were analyzed by hybridization with DNA containing actinorhodin biosynthetic genes (actI, II, III, IV, VA, VB, VI and VII). Both fragments hybridized with the actI, III, VA and VI regions, but not with the actII, IV, VB and VII regions. The cloned fragment of S. tanashiensis DNA was analyzed by complementation tests with kalafungin-nonproducing mutants. Seven genes (kalI approximately VII), which correspond to seven steps in kalafungin biosynthesis, were found to be located on a 14 kb continuous DNA fragment. Five of the genes were located on the regions homologous to the genes for actinorhodin biosynthesis, but the other two genes were not. Although kalafungin is an intermediate or shunt product in actinorhodin biosynthesis in S. coelicolor A3(2), the genes for kalafungin biosynthesis in S. tanashiensis are not identical with those in S. coelicolor A3(2).
Specificity analysis of human anti-DNA antibodies. (1986)

Human hybrids producing anti-DNA antibodies were generated by the fusion of pokeweed mitogen-stimulated splenic lymphocytes from a child with sickle cell anemia to GM4672. Of 19 hybrids, three (15%) produced anti-DNA antibody as detected by an enzyme linked immunosorbent assay. One subclone from each of these three hybrids was then characterized. All produced IgM antibody in large amounts ranging from 22 to 266 micrograms/ml per million cells per 24 hr. All three antibodies bound both double- and single-stranded DNA. Competitive inhibition assays revealed the greatest inhibition of DNA binding with the ribohomopolymers polyinosinic and polyguanylic acid. A complex pattern of cross-reactivity with various other polynucleotides and with some phospholipids was observed. Subtle differences were found among the three antibodies in light chain class and some of the binding specificities. By using a modified Farr assay, all three monoclonals were found to be of low to intermediate affinity. These results confirm that anti-DNA antibodies apparently equivalent to those seen in patients with SLE can be derived from "normal" nonautoimmune individuals.
The Energy Source for Bioluminescence in an Isolated System (1947)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
Cushion treemaps: visualization of hierarchical information (2003)

A new method is presented for the visualization of hierarchical information, such as directory structures and organization structures. Cushion treemaps inherit the elegance of standard treemaps: compact, space-filling displays of hierarchical information, based on recursive subdivision of a rectangular image space. Intuitive shading is used to provide insight in the hierarchical structure. During the subdivision, ridges are added per rectangle, which are rendered with a simple shading model. The result is a surface that consists of recursive cushions. The method is efficient, effective, easy to use and implement, and has a wide applicability.
Rubber Insulators for Pole Lines (1949)

Glass insulators on pole lines in some areas are subject to much mischievous breakage by children and hunters who utilize them in target practice, sometimes to the extent that almost weekly replacements are necessary. To solve the problem, a vulcanized rubber insulator has been developed which has proved in test to be both durable and efficient.
Performance of Image Analysis for Assessment of Simulated Spray Droplet Distribution (1994)

Various distribution patterns of spray droplets were simulated with Autosketch V.2 software and images of specks were printed on a Laserjet 2 printer. The specks were studied with a Dapple Systems image analyzer and Imageplus+ software. The objectives were to evaluate the utility of image analysis for spray deposition assessment and determine the effects of image area, speck size, and number of specks on the accuracy of the measurements.
A compilation flow for parametric dataflow (2014)

Efficient programming of signal processing applications on embedded systems is a complex problem. High level models such as Synchronous dataflow (SDF) have been privileged candidates for dealing with this complexity. These models permit to express inherent application parallelism, as well as analysis for both verification and optimization. Parametric dataflow models aim at providing sufficient dynamicity to model new applications, while at the same time maintaining the high level of analyzability needed for efficient real life implementations.
Optimizing near-ML MIMO detector for SDR baseband on parallel programmable architectures (2008)

ML and near-ML MIMO detectors have attracted a lot of interest in recent years. However, almost all the reported implementations are delivered in ASICs or FPGAs. Our contribution is optimizing the near-ML MIMO detector for parallel programmable architectures, such as those with ILP and DLP features. In the proposed SSFE (Selective Spanning with Fast Enumeration), architecture-friendliness is explicitly introduced from the very beginning of the design flow. Importantly, high level algorithmic transformations make the dataflow pattern and structure fit architecture-characteristics very well. We enable abundant vector-parallelism with highly regular and deterministic dataflow in the SSFE; memory rearrangements, shuffling and non-predictable dynamism are all elaborately excluded. Hence, the SSFE can be easily parallelized and efficiently mapped onto ILP and DLP architectures. Furthermore, to fine-tune the SSFE on parallel architectures, extensive pre-compiler transformations are applied with the help of the application-level information. These optimize not only computation-operations but also address-generations and memory-accesses. Experiments show that the SSFE brings very efficient resource-utilizations on real-life VLIW architectures. Specifically, with the SSFE the percentage of NOPs instructions on VLIW is below 1%, even better than that achieved by the software-pipelined FFT. To the best of our knowledge, this is the first reported work about comprehensive optimizations of near-ML MIMO detectors for parallel programmable architectures.
Evaluation of false ultrasonographic diagnoses in cows by measuring plasma levels of bovine pregnancy‐associated glycoprotein 1 (1998)

Between days 27 and 59 after artificial insemination (AI), 189 ultrasonographic pregnancy diagnoses were made in 56 dairy cows using a 7.5 MHz linear-array rectal transducer. Blood samples were withdrawn from a jugular vein on the day of AI, on day 21, and after each ultrasonographic examination between days 27 and 31, days 34 and 38, days 41 and 45 and days 55 and 59 after AI. Plasma concentrations of bovine pregnancy-associated glycoprotein 1 (bPAG-1) were measured by radioimmunoassay. The results showed that before day 31, ultrasonographic scanning was not very sensitive because six of the 30 calving cows were incorrectly diagnosed as non-pregnant. In five of these animals, the uterus was located far cranial to the pelvic inlet. Five of the cows examined between days 27 and 31 were pregnant on the basis of plasma bPAG-1 levels on the same day, using 0.5 ng/ml as the cut-off point. Plasma levels of bPAG-1 and progesterone proved that four of the cows which had early positive ultrasonographic diagnoses but did not produce a calf, were pregnant when they were examined.
Transgenic Potato Virus Y Resistance in Potato: Evidence for an RNA-Mediated Cellular Response (1995)

This study was undertaken to assess the potential of transgenic RNA-mediated virus resistance in potato. Transgenes that expressed various versions of the potato virus Y (PVY) coat protein (CP) open reading frame (ORF) were constructed and expressed in potato. Plants highly resistant to PVY infection could be generated by expressing transgenes from which either mRNA and CP or only an untranslatable mRNA were made. An inverse correlation between transgene transcript accumulation and virus resistance was often noted when translatable or untranslatable versions of the PVY CP ORF were expressed. The data suggest that virus resistance is likely mediated by a host cell response. A dominant negative phenotype resulting from the transgene product competing with the viral-encoded product is not supported by the data.