gebhart/patrepeval huggingface dataset:
Electrophysiological properties of neonatal mouse cardiac myocytes in primary culture. (1994)

1. The increasing utility of transgenic mice in molecular studies of the cardiovascular system has motivated us to characterize the ionic currents in neonatal mouse ventricular myocytes. 2. Cell capacitance measurements (30 +/- 1 pF, n = 73) confirmed visual impressions that neonatal mouse ventricular myocytes in primary culture are considerably smaller than freshly isolated adult ventricular myocytes. With the use of electron microscopy, mitochondria and sarcoplasmic reticulum were found in close association with myofibrils, but transverse tubules were not observed. 3. Action potential durations, measured at 50 and 90% repolarization, were 23 +/- 1 and 42 +/- 2 ms respectively (n = 46). Application of 4-aminopyridine (4-AP; 5 mM) prolonged action potential duration at 50% repolarization by 26 +/- 5% (n = 3). The brevity of the action potential is explained by the rapid activation of a transient outward K+ current upon voltage-clamp depolarization to plateau potentials. 4. Potassium currents identified include an inward rectifier, a large 4-AP-sensitive transient outward, a slowly inactivating 4-AP-insensitive outward, a slowly activating delayed rectifier and a small rapidly activating E-4031 (10 microM)-sensitive delayed rectifier K+ current. 5. Sodium currents (-305 +/- 50 pA pF-1, n = 21) were recorded in 40 mM Na+ with Ni2+ (1 mM) to block Ca2+ currents and with K+ replaced by Cs+. The relative insensitivity of the Na+ current to block by tetrodotoxin (IC50 = 2.2 +/- 0.3 microM, n = 4) is distinctive of the cardiac Na+ channel isoform. 6. Nitrendipine-insensitive (10 microM) Ba2+ currents elicited during steps from -90 to -30 mV measured -25 +/- 5 pA pF-1 (n = 7, 30 mM Ba2+). Decay of these currents was complete during 180 ms depolarizations, even with Ba2+ as the charge carrier. These currents were not present when the holding potential was set at -50 mV. These data support the presence of a low threshold, T-type Ca2+ current. 7. The maximal nitrendipine-sensitive L-type Ca2+ current density was -10 +/- 2 pA pF-1 (n = 8) in 2 mM Ca2+ and -38 +/- 5 pA pF-1 (n = 9) in 30 mM Ba2+. Exposure to isoprenaline (1 microM) resulted in an 82% increase (n = 3) in the amplitude of the Ba2+ currents elicited at 0 mV. 8. Neonatal mouse cardiac myocytes in primary culture possess surprisingly large inward currents given the brevity of their action potentials.(ABSTRACT TRUNCATED AT 250 WORDS)
“It All Makes Us Feel Together”: Young People's Experiences of Virtual Group Music-Making During the COVID-19 Pandemic (2021)

We know little about the psychological experiences of children and young people who have participated in virtual group music-making during the Coronavirus disease (COVID-19) pandemic. Adopting a mixed-methods design, we worked across three music education hubs in the UK, with a total 13 virtual music groups. These included a range of mainstream ensembles, inclusive ensembles targeting young people with special educational needs and/or disabilities, and inclusive music production spaces, targeting young people from lower socio-economic backgrounds. Reported progress in intra- and inter-personal psychological outcomes was investigated using quantitative and qualitative staff session reports, which were collected since before the pandemic (n1 for in-person sessions = 87, n2 for virtual sessions = 68), and surveys distributed to tutors, young people, and their parents during the first and second United Kingdom (UK) national lockdowns (n3 for qualitative responses = 240, n4 for quantitative responses = 96). Satisfaction of three basic psychological needs of self-determination theory and their relation to joint music-making in virtual spaces was also observed in real time by the researchers performing quantitative checklist observations on 16 separate occasions. Findings indicated that virtual music groups represented a meaningful psychological resource for the participating children and young people, especially considering the lack of opportunities offered by their schools and other extra-curricular activities. Through their participation with virtual group music-making activities, young people used music as a tool for self-expression and emotion management, restored lost musical identities and confidence, and preserved treasured social connections. Virtual alternatives to group music-making appear to indirectly nurture the sense of belongingness, mediated by supportive staff behaviors, but their direct connection, which has been widely reported for in-person group music-making experiences, has not been observed in virtual music groups.
Cancer Associated Fibroblasts Promote Tumor Growth and Metastasis by Modulating the Tumor Immune Microenvironment in a 4T1 Murine Breast Cancer Model (2009)

Our findings demonstrate that cancer associated fibroblasts promote tumor growth and metastasis through their role as key modulators of immune polarization in the tumor microenvironment and are valid targets for therapy of metastatic breast cancer.
Estimation of Regression Coefficients When Some Regressors are not Always Observed (1994)

Abstract In applied problems it is common to specify a model for the conditional mean of a response given a set of regressors. A subset of the regressors may be missing for some study subjects either by design or happenstance. In this article we propose a new class of semiparametric estimators, based on inverse probability weighted estimating equations, that are consistent for parameter vector α0 of the conditional mean model when the data are missing at random in the sense of Rubin and the missingness probabilities are either known or can be parametrically modeled. We show that the asymptotic variance of the optimal estimator in our class attains the semiparametric variance bound for the model by first showing that our estimation problem is a special case of the general problem of parameter estimation in an arbitrary semiparametric model in which the data are missing at random and the probability of observing complete data is bounded away from 0, and then deriving a representation for the efficient score, the semiparametric variance bound, and the influence function of any regular, asymptotically linear estimator in this more general estimation problem. Because the optimal estimator depends on the unknown probability law generating the data, we propose locally and globally adaptive semiparametric efficient estimators. We compare estimators in our class with previously proposed estimators. We show that each previous estimator is asymptotically equivalent to some, usually inefficient, estimator in our class. This equivalence is a consequence of a proposition stating that every regular asymptotic linear estimator of α0 is asymptotically equivalent to some estimator in our class. We compare various estimators in a small simulation study and offer some practical recommendations.
[Ultrasound hearing by humans: objectivation with brain stem potentials (author's transl)]. (1980)

Early acoustic evoked potentials (brain stem evoked response) may be received by bone conduction after ultrasound irritation (40 kHz). In comparison with the brain stem potential which is received by the some bone conduction by 4 kHz there are differences in the pattern of the potential and in the latency shift. It may be thought of a retro-cochleare perception of the ultrasound because of the 1 msec earlier potential.
Hitting a home run: EP Minerals launches Game Changer (2014)

Jeff Kitchens, vice president of performance aggregates for EP Minerals, told IM: This product is an incredible leap forward to manage baseball infields and solve problems for today's groundskeepers. It controls dust, keeps the fields moist, and keeps playing conditions consistent for the whole game.

The biggest complaint was the amount of dust during the latter innings of the game (...) they asked us to create a product that would make the infields less dusty. While fields are watered right before the game starts, the field would be dry by the 6 th or 7 th inning - leading to lots of dust and hard fields. And, if they choose to water the infields again in the later innings, this led to muddy conditions and increased water usage. We needed to develop a product to solve this problem, EP Minerals' spokesperson added.

EP Minerals has developed four versions of Game Changer for different infield uses: Game Changer with KT3 Technology, Game Changer Regular Conditioner, Game Changer Mound Clay, and Game Changer Drying Agent.
Ruptured aneurysm of the gastroduodenal artery: a case report. (1991)

The authors report about a patient who presented three weeks after reconstruction of an infrarenal aortic abdominal aneurysm a rupturing aneurysm of the gastroduodenal artery. The symptoms and method of treatment of this rare condition are described on the basis of a literature survey.
Sensor Fusion Based Pipeline Inspection for the Augmented Reality System (2019)

Augmented reality (AR) systems are becoming next-generation technologies to intelligently visualize the real world in 3D. This research proposes a sensor fusion based pipeline inspection and retrofitting for the AR system, which can be used in pipeline inspection and retrofitting processes in industrial plants. The proposed methodology utilizes a prebuilt 3D point cloud data of the environment, real-time Light Detection and Ranging (LiDAR) scan and image sequence from the camera. First, we estimate the current pose of the sensors platform by matching the LiDAR scan and the prebuilt point cloud data from the current pose prebuilt point cloud data augmented on to the camera image by utilizing the LiDAR and camera calibration parameters. Next, based on the user selection in the augmented view, geometric parameters of a pipe are estimated. In addition to pipe parameter estimation, retrofitting in the existing plant using augmented scene are illustrated. Finally, step-by-step procedure of the proposed method was experimentally verified at a water treatment plant. Result shows that the integration of AR with building information modelling (BIM) greatly benefits the post-occupancy evaluation process or pre-retrofitting and renovation process for identifying, evaluating, and updating the geometric specifications of a construction environment.
High-speed quantum-well optoelectronic gate based on diffusive conduction recovery (1998)

A novel high-speed optoelectronic gate, based on electric field screening and ultrafast electrical recovery, is proposed, and demonstrated in principle with ultrathin barrier quantum wells. High-speed optical gates (operating, for example, on a picosecond time scale) are highly desirable for ultrafast information processing, such as in time-domain multiplexed networks and telecommunications. Nonlinear optical gates can give the necessary speed, but often take too much energy or power, and are not conveniently integrable with silicon electronics for control or information read-out. Optoelectronic devices can be conveniently small and readily interfaced with electronics, but are often slowed down by the finite speeds of electrical connections. Here we propose a novel optoelectronic device that can run with low optical energies, can be integrated readily with electronic information processing, and avoids the usual speed limitations of electrical connections. We also show preliminary data from a first such device.
Robust 3D segmentation for underwater acoustic images (2004)

A technique for 3D acoustic image segmentation and modelling is proposed. Especially, in the underwater environment, in which optical sensors suffer from visibility problems, the acoustical devices may provide efficient solutions, but, on the other hand, acoustic image interpretation is surely more difficult for a human operator. The proposed application involves the use of an acoustic camera which directly acquires images structured as a set of 3D points. Due to the noisy nature of this type of data, the segmentation problem becomes more challenging and the standard algorithms for range image segmentation are likely to fail. The proposed method is based on a simplified version of the so called recover and select paradigm in which the seed areas, from which the segmentation starts, are generated by adopting a robust approach based on the RANSAC (Random Sample And Consensus) algorithm. Superquadric primitives are directly recovered from raw data without any pre-segmentation processing. Experimental trials using both synthetic and real acoustical images confirm the goodness of the method, and a large robustness of the resulting segmented images, associated to a relatively low computational load.
Energy efficient wireless video communications for the digital set-top box (2003)

In the future, digital set-top boxes may serve as the primary access point for wireless home networks, enabling mobile users to use videoconferencing as well as streaming applications on hand-held devices. In this scenario, an important issue that must be addressed is the limited energy supply of a mobile device. This is of course a relevant issue for any wireless device. We focus on methods for efficiently utilizing transmission energy in wireless video communications. We present a general framework for the problem of minimizing the transmission energy required to provide an acceptable level of video quality. We discuss two special cases in which communication resources are adjusted simultaneously with the source coding parameters in order to provide (i) packet loss adaptation and (ii) transmission rate adaptation.
Syntheses of 2′-<i>O</i>-Methylisocytidine Phosphoramidite and Methylphosphonamidite Synthons (1996)

Abstract The 2′-O-methylisocytidine phosphoramidite synthon 7 and methylphosphonamidite synthon 8 are synthesized from 2′-O-methyluridine. The N2 -(N′, N′-dimethylformamidine) protected 2′-O-methylisocytidine is stable to basic deamination and acidic depyrimidination. Synthon 7 and synthon 8 have been incorporated into oligomers via the automated solid state procedure. This paper is dedicated to the 75th birthday of Dr. Yoshihisa Mizuno. Notes This paper is dedicated to the 75th birthday of Dr. Yoshihisa Mizuno.
Extracellular calcium influx stimulates metalloproteinase cleavage and secretion of heparin-binding EGF-like growth factor independently of protein kinase C (1998)

The phorbol ester, tetradecanoyl-phorbol 13-acetate (TPA), stimulates rapid proteolytic processing of the transmembrane, pro- form of heparin-binding epidermal growth factor-like growth factor (HB-EGF) at cell surfaces, suggesting the involvement of protein kinase C (PKC) isoforms in the HB-EGF secretion mechanism. To test this possibility, we expressed a chimeric protein, consisting of proHB-EGF fused to placental alkaline phosphatase (AP) near the amino terminus of processed HB-EGF, in NbMC-2 prostate epithelial cells. The proHB-EGF-AP chimera localized to plasma membranes and functioned as a diphtheria toxin receptor. Secreted HB-EGF-AP bound to heparin and exhibited potent growth factor activity. The presence of the AP moiety allowed highly quantitative measurements of cleavage-secretion responses of proHB-EGF to extracellular stimuli. As expected, rapid secretion of HB-EGF-AP was induced in a time- and dose-dependent manner by TPA. However, this was also observed with the Ca2+ ionophore, ionomycin, suggesting the involvement of extracellular Ca2+ ions in the secretion mechanism. Ionomycin-induced secretion was inhibited by extracellular calcium chelation but not by the PKC inhibitors, GF109203X, staurosporine, or chelerythrine. The TPA-mediated secretion effect was inhibited by staurosporine, GF109203X, and by pretreatment with TPA, but not by calcium chelation. A small secretion response was induced by thapsigargin, which releases Ca2+ from intracellular stores, but this was completely eliminated by extracellular calcium chelation. Ionomycin- and TPA-induced HB-EGF-AP secretion was not dependent on the presence of the proHB-EGF cytoplasmic domain and was specifically inhibited by the metalloproteinase inhibitors 1,10-phenanthroline and tissue inhibitor of metalloproteinase-1 (TIMP-1). These data demonstrate that extracellular Ca2+ influx activates a membrane-associated metalloproteinase to process proHB-EGF by a pathway that does not require PKC.
Experimental methods for investigating protein adsorption kinetics at surfaces (1994)

The adsorption of proteins at the solid-liquid interface is a process of fundamental importance in nature. Extensive reviews (MacRitchie, 1978; Andrade & Hlady, 1986; Norde, 1986) testify to the strong interest which has been shown in the problem during the past few decades. Norde & Lyklema (1978) have rightly pointed out that protein adsorption is scientifically intriguing; the phenomenology is complicated and includes many presently apparently irreconcilable observations.
Rheological characterization of fast‐reacting thermosets through spiral flow experiments (1992)

Abstract The standard spiral flow test is normally used to assess the “moldability” of thermosetting materials. It is proposed that such tests can be modified and analyzed to yield rheological information as from a viscometer. Specifically, a “parameter‐identification” scheme is developed to determine the constants in a viscosity model by minimizing the difference between the outcome of spiral flow tests and the results of numerical simulations of these tests. The proposed scheme is particularly applicable to fast‐reacting thermosets for which typical viscometers cannot be used. Successful application of the scheme is demonstrated for a particular encapsulating epoxy material, where constants are obtained for a modified WLF equation viscosity model. These constants are used to predict the outcome of spiral flow experiments not involved in the minimization procedure. A favorable comparison between experiment and simulation occurs at most operating conditions. The method requires no elaborate equipment or delicate instrumentation.
Miniature Low-Mass Drill Actuated by Flextensional Piezo Stack (2010)

Recent experiments with a flextensional piezoelectric actuator have led to the development of a sampler with a bit that is designed to produce and capture a full set of sample forms including volatiles, powdered cuttings, and core fragments. The flextensional piezoelectric actuator is a part of a series of devices used to amplify the generated strain from piezoelectric actuators. Other examples include stacks, bimorphs, benders, and cantilevers. These devices combine geometric and resonance amplifications to produce large stroke at high power density. The operation of this sampler/drill was demonstrated using a 3x2x1-cm actuator weighing 12 g using power of about 10-W and a preload of about 10 N. A limestone block was drilled to a depth of about 1 cm in five minutes to produce powdered cuttings. It is generally hard to collect volatiles from random surface profiles found in rocks and sediment, powdered cuttings, and core fragments. Toward the end of collecting volatiles, the actuator and the bit are covered with bellows-shaped shrouds to prevent fines and other debris from reaching the analyzer. A tube with a miniature bellows (to provide flexibility) is connected to the bit and directs the flow of the volatiles to the analyzer. Another modality was conceived where the hose is connected to the bellows wall directly to allow the capture of volatiles generated both inside and outside the bit. A wide variety of commercial bellows used in the vacuum and microwave industries can be used to design the volatiles capture mechanism. The piezoelectric drilling mechanism can potentially be operated in a broad temperature range from about-200 to less than 450 C. The actuators used here are similar to the actuators that are currently baselined to fly as part of the inlet funnel shaking mechanism design of MSL (Mars Science Laboratory). The space qualification of these parts gives this drill a higher potential for inclusion in a future mission, especially when considering its characteristics of low mass, small size, low power, and low axial loads for sampling.
Clinical characteristics, diagnosis and treatment of prolaetin pituitary adenoma (2009)

Objective To prove the clinical characteristics, diagnosis and treatment of prolactin pituitary adenoma. Methods The clinical presentations, imaging studies, endocrine and surgical outcomes in 45 patients with invasive prolactin pituitary adenomas and 67 patients with nonin - vasive prolactin pituitary adenomas were analyzed retrospectively. Results Invasive pituitary adenomas were more common in patients with macroadenomas than those with micro- adenomas( P ＜0.01 ). The occurrence of pituitary apoplexy was higher in invasion pituitary adenomas patients than those noninvasion ( P＜0.05 ). The rate of total tumor resection was lower and the rate of post operative recurrence was higher in patients with invasive tumors than those with noninvasive tumors ( P＜0.01 ). Conclusions The diagnosis and treatment of invasion prolactin pituitary adenoma are complicated. The postoperation treatment is often necessary in invasive pituitary adenoma patients.

Key words: 
Prolactin; Pituitary adenoma; Diagnosis; Treatment
Autoimmunity in Chagas disease cardiopathy: biological relevance of a cardiac myosin-specific epitope crossreactive to an immunodominant Trypanosoma cruzi antigen. (1995)

Heart tissue destruction in chronic Chagas disease cardiopathy (CCC) may be caused by autoimmune recognition of heart tissue by a mononuclear cell infiltrate decades after Trypanosoma cruzi infection. Indirect evidence suggests that there is antigenic crossreactivity between T. cruzi and heart tissue. As there is evidence for immune recognition of cardiac myosin in CCC, we searched for a putative myosin-crossreactive T. cruzi antigen. T. cruzi lysate immunoblots were probed with anti-cardiac myosin heavy chain IgG antibodies (AMA) affinity-purified from CCC or asymptomatic Chagas disease patient-seropositive sera. A 140/116-kDa doublet was predominantly recognized by AMA from CCC sera. Further, recombinant T. cruzi protein B13--whose native protein is also a 140- and 116-kDa double band--was identified by crossreactive AMA. Among 28 sera tested in a dot-blot assay, AMA from 100% of CCC sera but only 14% of the asymptomatic Chagas disease sera recognized B13 protein (P = 2.3 x 10(-6)). Sequence homology to B13 protein was found at positions 8-13 and 1442-1447 of human cardiac myosin heavy chain. Competitive ELISA assays that used the correspondent myosin synthetic peptides to inhibit serum antibody binding to B13 protein identified the heart-specific AAALDK (1442-1447) sequence of human cardiac myosin heavy chain and the homologous AAAGDK B13 sequence as the respective crossreactive epitopes. The recognition of a heart-specific T. cruzi crossreactive epitope, in strong association with the presence of chronic heart lesions, suggests the involvement of crossreactivity between cardiac myosin and B13 in the pathogenesis of CCC.