gebhart/patrepeval huggingface dataset:
Biological basis of omeprazole therapy. (1989)

There are two means of reducing acid secretion. The best studied is inhibition of stimulation of the parietal cell. There are three major types of receptors that activate secretion by this cell and two classes of receptor antagonists, as well as at least two intracellular messenger pathways. The receptors are for histamine (H2 subtype), acetyl choline (M2 subtype) and gastrin. Antagonists of these receptors include the H2-antagonist class (Tagamet, Zantac and Pepcid), the M1 muscarinic antagonists (pirenzepine, telenzepine) and the gastrin antagonist, proglumide. The major pathway for stimulation appears to be the H2-receptor, since this is the only receptor that stimulates adenylate cyclase, and both acetyl choline and gastrin release histamine locally within the gastric mucosa. However, these agonists elevate intracellular calcium, which has a partially independent action on acid secretion. Accordingly, the most efficacious type of receptor antagonist will be of the H2 class, which is borne out by clinical experience. Prostaglandins of the E type prevent adenylate cyclase stimulation by histamine and are also effective antisecretory agents. It will be difficult to abolish acid secretion entirely by a single receptor antagonist, although longer-acting H2-antagonists should show clinical superiority to short-acting antagonists of this type. An alternative approach to acid suppression is to block the terminal step of acid secretion, the gastric proton pump (H+, K(+)-ATPase). This enzyme is virtually unique to the parietal cell and, when active, forms a very acidic space within the parietal cell called the secretory canaliculus. Activation of acid secretion involves several steps. The enzyme is present in cytosolic membranes when the cell is at rest and moves to the membrane of the secretory canaliculus when stimulated. Simultaneously, there is an increased permeability of potassium chloride (KCl), which allows presentation of K+ to the luminal surface of the pump and H+ for K+ exchange. The result is the secretion of HCl into the canaliculus, and hence into the gland lumen and then the stomach. There are two classes of pump inhibitors. One class is K+ competitive and relatively selective for the H+, K(+)-ATPase, as exemplified by SCH28080. This class has not yet been used in man. The other class is specific to the functioning H+, K(+)-ATPase in the stomach. It is exemplified by omeprazole (Losec). This compound is a weak base with a pKa of 4. In the unprotonated, uncharged form it will penetrate cell membranes and, at pH less than 4, it becomes protonated and therefore charged.(ABSTRACT TRUNCATED AT 400 WORDS)
Existence of a plant tyrosylprotein sulfotransferase: novel plant enzyme catalyzing tyrosine <i>O</i>‐sulfation of preprophytosulfokine variants in vitro (2000)

An in vitro assay system to detect tyrosylprotein sulfotransferase (TPST) activity of higher plant cells was established, using synthetic oligopeptides based on the deduced amino acid sequence of a phytosulfokine-alpha (PSK-alpha) precursor. TPST activity was found in microsomal membrane fractions of rice, asparagus and carrot cells and it was confirmed that acidic amino acid residues adjacent to the tyrosine residues of acceptor peptides were essential to the sulfation reaction. The asparagus TPST exhibited a broad pH optimum of 7.0-8.5, required manganese ions for maximal activity and appeared to be a membrane-bound protein localized in the Golgi apparatus. These enzymes should be defined as a new class of plant sulfotransferases that catalyze tyrosine O-sulfation of a PSK-alpha precursor and other unknown proteins.
Expression Profiling of Sulfotransferases in Human Cell Lines Derived from Extra-Hepatic Tissues. (2001)

To explore the physiological roles of sulfotransferases (SULTs) in extra-hepatic tissues, we examined the expression of eight SULT genes by reverse transcription (RT)-PCR in human cell lines that were established from various tissues. Expression levels of SULTs were low in neural cell lines such as NB-1 and GI-1, and high in epithelial cell lines, such as Caco-2 and BeWo. SULT1C2 expression was abundant in all cell types, whereas that of SULT1E1, SULTIBI or SULT2B1 was restricted to a specific cell type. SULT1C1, which can catalyze the sulfation of N-hydroxy-2-acetylaminofluorene, was expressed in Caco-2, BeWo and KB562. Induction of differentiation did not generally affect SULT expression, although that of SULT1C2 was reduced after differentiation of the neuroblastoma cell line, NB-1, was induced. The profile of SULT expression in the culture cells obtained here gives clues to understanding the physiological roles of SULT enzymes in extra-hepatic tissues or organs.
Adding OWL-S to UDDI, implementation and throughput (2004)

Abstract. The increasing availability of web services demands for a discovery mechanism to find services that satisfy our requirement. UDDI provides a web wide registry of web services, but its lack of an explicit capability representation and its syntax based search provided produces results that are coarse in nature. We propose to base the discovery mechanism on OWL-S. OWL-S allows us to semantically describe web services in terms of capabilities offered and to perform logic inference to match the capabilities requested with the capabilities offered. We propose OWL-S/UDDI matchmaker that combines the better of two technologies. We also implemented and analyzed its performance. 1
A randomized controlled trial to test the efficacy of trans-tympanic injections of a sodium thiosulfate gel to prevent cisplatin-induced ototoxicity in patients with head and neck cancer (2019)

ClinicalTrials.gov, NTC02281006 , Registered 3 November 2014.
Let's go lab: a platform for evaluation of spoken dialog systems with real world users. (2008)

This short paper is intended to advertise Let’s Go Lab, a platform for the evaluation of spoken dialog research. Unlike other dialog platforms, in addition to example dialog data and a portable software system, Let’s Go Lab affords evaluation with real users. Let’s Go has served the Pittsburgh public with bus schedule information since 2005, answering more than 52,000 calls to date.
Concise Review: Hitting the Right Spot with Mesenchymal Stromal Cells   (2010)

Mesenchymal stromal cells or mesenchymal stem cells (MSCs) have captured considerable scientific and public interest because of their potential to limit physical and immune injury, to produce bioactive molecules and to regenerate tissues. MSCs are phenotypically heterogeneous and distinct subpopulations within MSC cultures are presumed to contribute to tissue repair and the modulation of allogeneic immune responses. As the first example of efficacy, clinical trials for prevention and treatment of graft-versus-host disease after hematopoietic cell transplantation show that MSCs can effectively treat human disease. The view of the mechanisms whereby MSCs function as immunomodulatory and reparative cells has evolved simultaneously. Initially, donor MSCs were thought to replace damaged cells in injured tissues of the recipient. More recently, however, it has become increasingly clear that even transient MSC engraftment may exert favorable effects through the secretion of cytokines and other paracrine factors, which engage and recruit recipient cells in productive tissue repair. Thus, an important reason to investigate MSCs in mechanistic preclinical models and in clinical trials with well-defined end points and controls is to better understand the therapeutic potential of these multifunctional cells. Here, we review the controversies and recent insights into MSC biology, the regulation of alloresponses by MSCs in preclinical models, as well as clinical experience with MSC infusions (Table 1) and the challenges of manufacturing a ready supply of highly defined transplantable MSCs.
DNA Topoisomerases as Anticancer Drug Targets: From the Laboratory to the Clinic (2001)

DNA topoisomerases play important roles in basic cellular biology. Recently they have been identified as the molecular targets of a variety of pharmaceutical agents. Some of the drugs that target the topoisomerases are anticancer drugs. These anticancer drugs work by a novel mechanism of action. They inhibit the topoisomerase molecule from religating DNA strands after cleavage. This leaves a cell with DNA breaks, which if not repaired, become lethal. In other words, these drugs convert the topoisomerase molecule into a DNA damaging agent. This is a stoichiometric relationship. Each anticancer drug molecule has the potential of interacting with one topoisomerase molecule to cause one DNA lesion. The clinical implication of this mechanism of drug action is that sensitivity to topoisomerase targeting drugs should be dependent on high topoisomerase levels. This is clearly true in laboratory systems. With new developments in in situ immunohistochemistry, topoisomerase expression can now be easily estimated in human cancers. From this information, it may be possible to predict the sensitivity or resistance of human cancers to topoisomerase targeting anticancer drugs.
Development of a High Pressure Load Sensing Mobile Valve (1981)

<div class="htmlview paragraph">A program was initiated in 1975 to develop a high pressure load sensing valve for the Earthmoving and Construction Equipment market, with initial focus on excavators. The need for pilot operation, higher pressures, protection in case of line rupture, and improved metering dictated a departure from conventional approaches. A meter-out element which operates independently of a meter-in element was developed By incorporating the elements in an actuator mounted valve body, objectives were met. A description of operation is presented, along with performance results.</div>
Leading the Way to Increased Student Learning. (2006)

Corynebacterium glutamicum possesses two terminal oxidases, cytochrome aa3 and cytochrome bd. Cytochrome aa3 forms a supercomplex with the cytochrome bc1 complex, which contains an unusual diheme cytochrome c1. Both the bc1 -aa3 supercomplex and cytochrome bd transfer reducing equivalents from menaquinol to oxygen; however, they differ in their proton translocation efficiency by a factor of three. Here, we analyzed the role of cytochrome bd for growth and lysine production. When cultivated in glucose minimal medium, a cydAB deletion mutant of C. glutamicum ATCC 13032 grew like the wild type in the exponential phase, but growth thereafter was inhibited, leading to a biomass formation 40% less than that of the wild type. Constitutive overproduction of functional cytochrome bd oxidase in ATCC 13032 led to a reduction of the growth rate by approximately 45% and of the maximal biomass by approximately 35%, presumably as a consequence of increased electron flow through the inefficient cytochrome bd oxidase. In the L-lysine-producing C. glutamicum strain MH20-22B, deletion of the cydAB genes had only minor effects on growth rate and biomass formation, but lysine production was increased by approximately 12%. Thus, the respiratory chain was shown to be a target for improving amino acid production by C. glutamicum.
Deep Modular Co-Attention Networks for Visual Question Answering (2019)

Visual Question Answering (VQA) requires a fine-grained and simultaneous understanding of both the visual content of images and the textual content of questions. Therefore, designing an effective `co-attention' model to associate key words in questions with key objects in images is central to VQA performance. So far, most successful attempts at co-attention learning have been achieved by using shallow models, and deep co-attention models show little improvement over their shallow counterparts. In this paper, we propose a deep Modular Co-Attention Network (MCAN) that consists of Modular Co-Attention (MCA) layers cascaded in depth. Each MCA layer models the self-attention of questions and images, as well as the guided-attention of images jointly using a modular composition of two basic attention units. We quantitatively and qualitatively evaluate MCAN on the benchmark VQA-v2 dataset and conduct extensive ablation studies to explore the reasons behind MCAN's effectiveness. Experimental results demonstrate that MCAN significantly outperforms the previous state-of-the-art. Our best single model delivers 70.63$\%$ overall accuracy on the test-dev set. Code is available at https://github.com/MILVLG/mcan-vqa.
SIMPLE DECISION RULES FOR ACCEPTANCE OF MIXED TRAFFIC STREAMS (1988)

Mixed traffic means different bandwidth requirements for different types of calls. In asynchronous transfer mode (atm), to be used in the future broadband isdn, the calls will use virtual connections. In this context it is not obvious whether a new call can be accepted or not. A detailed decision rule is given for different traffic streams, based on probability calculations of the number of active virtual connections. Also a simpler decision rule is derived by approximate analysis, in which each connection belongs to one of two possible traffic streams. Here the decision rule is based on a simple formula for the allowed mean aggregate atm channel loading.(a)
Design Theory and Separations in Preparative-Scale Continous-Flow Annular-Bed Electropheresis (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDesign Theory and Separations in Preparative-Scale Continous-Flow Annular-Bed ElectropheresisTheodore Vermeulen, Louie Nady, John M. Krochta, Edo Ravoo, and Darryl HoweryCite this: Ind. Eng. Chem. Process Des. Dev. 1971, 10, 1, 91–102Publication Date (Print):January 1, 1971Publication History Published online1 May 2002Published inissue 1 January 1971https://doi.org/10.1021/i260037a018RIGHTS & PERMISSIONSArticle Views49Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alerts
On-line fault detection and diagnosis obtained by implementing neural algorithms on a digital signal processor (1996)

A measurement instrument for on-line fault detection and diagnosis is proposed. It is based on the implementation of a neural network algorithm on a processor specialized in digital signal processing and provided with suitable data acquisition and generation units. Two specific implementations are detailed. The former uses the neural-network to simulate on-line the correct system behavior, thus allowing the fault detection to be achieved by comparing the neural network output with the measured one. The latter uses the neural network to classify on-line the system as correct or faulty, thus allowing the fault detection and diagnosis to be achieved simultaneously. These two implementations are applied to detect on-line and diagnose faults on a real system in order to point out different fields of application and to highlight the performance of the measurement apparatus.
The TD-2 Microwave Radio Relay System (1951)

Here he has been engaged in the study
A computationally efficient complete area coverage algorithm for intelligent mobile robot navigation (2014)

Complete area coverage navigation (CAC) requires a special type of robot path planning, where the robots should visit every point of the state workspace. CAC is an essential issue for cleaning robots and many other robotic applications. Real-time complete area coverage path planning is desirable for efficient performance in many applications. In this paper, a novel vertical cell-decomposition (VCD) with convex hull (VCD-CH) approach is proposed for real-time CAC navigation of autonomous mobile robots. In this model, a vertical cell-decomposition (VCD) methodology and a spanning-tree based approach with convex hull are effectively integrated to plan a complete area coverage motion for autonomous mobile robot navigation. The computational complexity of this method with minimum trajectory length planned by a cleaning robot in the complete area coverage navigation with rectangle obstacles in the Euclidean space is O(n log n). The performance analysis, computational validation and comparison studies demonstrate that the proposal model is computational efficient, complete and robust.
Attenuated response of p53 and p21 in primary cultures of human prostatic epithelial cells exposed to DNA-damaging agents. (1995)

The multifocal origin of prostate cancer suggests a pan-organ defect in a tumor suppressor pathway. Although structural mutations in the p53 gene have been implicated in late-stage prostate cancer, little is known about the p53 response to genotoxic stress in normal human prostatic epithelial cells from which adenocarcinomas originate. We found that the majority (10 of 12) of epithelial cell cultures derived from histologically normal tissues of radical prostatectomy specimens failed to exhibit p53 accumulation in response to ionizing radiation. Epithelial cell cultures derived from benign prostatic hyperplasia and a primary prostatic adenocarcinoma also failed to accumulate p53 in response to ionizing radiation. In contrast, cultures of prostatic stromal cells derived from normal, benign prostatic hyperplasia, or adenocarcinoma tissues exhibited a 3-9-fold induction of p53 within 1-3 h after irradiation. Since p53 regulates a cell cycle checkpoint through the induction of the cyclin-cdk inhibitor p21, we examined p21 accumulation and cell cycle arrest following exposure to ionizing radiation. With one exception, epithelial cells that did not display increased p53 or p21 induction did not demonstrate a significant G1-S arrest in response to ionizing radiation, whereas stromal cells that accumulated p53 and p21 exhibited a large cell cycle arrest. These results indicate a functional difference between the DNA damage response of epithelial and stromal prostatic cells and suggest a possible mechanism for the increased susceptibility of prostatic epithelial cells to accumulate genetic alterations.
Constituents of Domestic Citrus Plants. PartXXXII. Four New Acridone-Coumarin Dimers from a Citrus Plant. (1998)

Four new acridone-coumarin dimers, neoacrimarines-H (1), -I (2), -J (3) and -K (4), were isolated from the roots of Marsh grapefruit (Citrus paradisi MACF.). The structures of these new compounds were elucidated by spectral analysis especially using heteronuclear multiple-bond correlation (HMBC) and nuclear Overhauser effect experiments.
[Stimulation of epidermal growth in equivalent skin by tissue inhibitor of metalloproteases]. (1990)

Tissue inhibitor of metalloproteases (TIMP) is a major regulator of extracellular matrix synthesis and degradation. Moreover elevated tissue inhibitor of metalloproteases levels are found in the blister fluid of many diseases, suggesting that tissue inhibitor of metalloproteases plays a role in epidermal and dermal wound healing. The aim of this work was to study the effects of human recombinant tissue inhibitor of metalloproteases in a skin equivalent model used to evaluate the effects of drugs on epidermal and dermal components. Planimetry, DNA assays, and histologic studies showed that tissue inhibitor of metalloproteases enhanced the growth of normal human keratinocytes on dermal equivalent. Thus, the extracellular matrix regulator tissue inhibitor of metalloproteases also stimulates the growth of keratinocytes. Identity of the gene encoding tissue inhibitor of metalloproteases and Erythroid Potentiating Activity (EPA) has been reported. The effects of tissue inhibitor of metalloproteases on keratinocytes described herein are reminiscent of the stimulating effect of erythroid potentiating activity on the growth of erythroid precursors.
The Syntheses from Levulinic Acid. A Possible Use of Some 2-Methyl-5-oxopyrrolidine-2-carboxylic Esters as Plasticizers (1954)

Abstract The synthesis of 2-amino-2-methylglutaric acid from levulinic acid by Strecker’s method is reported. This acid gives 2-methyl-5-oxopyrrolidine-2-carboxylic acid on dehydration, and some of its esters were prepared and tested for plasticizer performance.
Interleukin‐12 Production by Dendritic Cells (1996)

Recent studies have demonstrated that the treatment of mice with anti-gp39 antibodies impairs T-cell functions in the murine collagen type II-induced arthritis model, in acute semi-allogenic graft-versus-host disease, and in the allo-specific CTL-reaction, that is, reactions that are believed to be mediated by Th1-type T cells. On the other hand, the administration of anti-gp39 antibody did not influence Th2 T-cells responses, suggesting that CD40-CD40L interactions are more crucial for Th1 than Th2 T-cell development. Recent studies also demonstrate that dendritic cells (DC) are capable of driving a Th1 T-cell response that is mediated by IL-12. In addition, stimulation of CD40 on human monocytes results in IL-12 production, suggesting that activated T cells expressing CD40L may directly induce the production of IL-12 by antigen-presenting cells, thus allowing for the generation of a Th1 T-cell response in the absence of intracellular pathogens. We investigated whether the CD40-CD40L interaction was important in the production of IL-12 by DCs in an in vitro system that allowed precise control of cytokine concentrations. Initially we showed that FACS-purified mouse spleen DCs produce high amounts of IL-12 p40 in response to CD40 crosslinking by CD40L-expressing fibroblasts. We then demonstrate that DCs also produce IL-12 p40 in a more physiologic system using purified DCs pulsed with ovalbumin (OVA) and then cultured with LECAM-1hi T cells from ovalbumin T-cell receptor transgenic mice. Finally, we show that IL-10 has a potent capacity to shut down CD40-induced IL-12 p40 secretion; and, in addition, IL-4 partially inhibits CD40-induced IL-12 p40 secretion and enhances IL-10-mediated inhibition in an additive fashion. We also investigated the in vivo relevance of this interaction in an experimental model for a Th1-mediated disease, the hapten reagent (TNBS)-induced colitis. The administration of anti-gp39 (CD40L) antibodies during the induction phase of the Th1 response completely prevented IFN-gamma production by CD4 T cells from the intestinal lamina propria and also the clinical and histological evidence of disease. In further studies we showed that the prevention of disease activity was due to an inhibition of IL-12 secretion. Thus, the injection of recombinant IL12 p75 heterodimer into TNBS + anti-gp39-treated mice reversed the effect of anti-gp39 and resulted in severe disease activity. In conclusion, these findings suggest that DCs produce IL-12 in response to CD40 signaling, that a mechanism by which IL-4 may induce Th2 development is by acting with IL-10 to inhibit IL-12 production by DCs, and that the CD40L-CD40 interaction is crucial for the IL-12-dependent priming of Th1 T cells in vivo.