gebhart/patrepeval huggingface dataset:
Quantification of right ventricular afterload in patients with and without pulmonary hypertension (2006)

Right ventricular (RV) afterload is commonly defined as pulmonary vascular resistance, but this does not reflect the afterload to pulsatile flow. The purpose of this study was to quantify RV afterload more completely in patients with and without pulmonary hypertension (PH) using a three-element windkessel model. The model consists of peripheral resistance (R), pulmonary arterial compliance (C), and characteristic impedance (Z). Using pulmonary artery pressure from right-heart catheterization and pulmonary artery flow from MRI velocity quantification, we estimated the windkessel parameters in patients with chronic thromboembolic PH (CTEPH; n = 10) and idiopathic pulmonary arterial hypertension (IPAH; n = 9). Patients suspected of PH but in whom PH was not found served as controls (NONPH; n = 10). R and Z were significantly lower and C significantly higher in the NONPH group than in both the CTEPH and IPAH groups (P < 0.001). R and Z were significantly lower in the CTEPH group than in the IPAH group (P < 0.05). The parameters R and C of all patients obeyed the relationship C = 0.75/R (R(2) = 0.77), equivalent to a similar RC time in all patients. Mean pulmonary artery pressure P and C fitted well to C = 69.7/P (i.e., similar pressure dependence in all patients). Our results show that differences in RV afterload among groups with different forms of PH can be quantified with a windkessel model. Furthermore, the data suggest that the RC time and the elastic properties of the large pulmonary arteries remain unchanged in PH.
An Eclectic DNA Structure Adopted by Human Telomeric Sequence Under Superhelical Stress And Low pH (1992)

We have found, with the aid of 2-D gel electrophoresis, that double-stranded human telomeric repeat, (T2AG3)12.(C3TA2)12, being cloned within a plasmid, forms a protonated superhelically-induced structure. Experiments on chemical and enzymatic probing also indicate that the human telomeric repeats adopt an unusual structure. We have proposed an eclectic model for this structure in which four different elements coexist: a non-orthodox intramolecular triplex stabilized by the canonical protonated C.G*C+ base-triads and highly enriched by noncanonical base-triads; the intramolecular quadruplex formed by a portion of the G-rich strand; the single-stranded region encompassing a portion of the G-rich strand and, probably, the (C,A)-hairpin formed by a portion of the C-rich strand.
Aboveground Forest Biomass Estimation with Landsat and LiDAR Data and Uncertainty Analysis of the Estimates (2012)

Landsat Thematic mapper (TM) image has long been the dominate data source, and recently LiDAR has offered an important new structural data stream for forest biomass estimations. On the other hand, forest biomass uncertainty analysis research has only recently obtained sufficient attention due to the difficulty in collecting reference data. This paper provides a brief overview of current forest biomass estimation methods using both TM and LiDAR data. A case study is then presented that demonstrates the forest biomass estimation methods and uncertainty analysis. Results indicate that Landsat TM data can provide adequate biomass estimates for secondary succession but are not suitable for mature forest biomass estimates due to data saturation problems. LiDAR can overcome TM’s shortcoming providing better biomass estimation performance but has not been extensively applied in practice due to data availability constraints. The uncertainty analysis indicates that various sources affect the performance of forest biomass/carbon estimation. With that said, the clear dominate sources of uncertainty are the variation of input sample plot data and data saturation problem related to optical sensors. A possible solution to increasing the confidence in forest biomass estimates is to integrate the strengths of multisensor data.
Joint Image Clustering and Labeling by Matrix Factorization (2015)

We propose a novel algorithm to cluster and annotate a set of input images jointly, where the images are clustered into several discriminative groups and each group is identified with representative labels automatically. For these purposes, each input image is first represented by a distribution of candidate labels based on its similarity to images in a labeled reference image database. A set of these label-based representations are then refined collectively through a non-negative matrix factorization with sparsity and orthogonality constraints; the refined representations are employed to cluster and annotate the input images jointly. The proposed approach demonstrates performance improvements in image clustering over existing techniques, and illustrates competitive image labeling accuracy in both quantitative and qualitative evaluation. In addition, we extend our joint clustering and labeling framework to solving the weakly-supervised image classification problem and obtain promising results.
Acute Iron Intoxication: Treatment Controversies (1987)

Accidental ingestion of iron-containing preparations is a common, serious pediatric problem. Despite the frequency of this type of ingestion, the treatment remains under dispute. Controversies surrounding the use of sodium bicarbonate and phosphate solutions for complexation, oral deferoxamine lavage, and the deferoxamine provocation test are discussed. Therapeutic recommendations are made based on a review of the literature.
AKXD recombinant inbred strains: models for studying the molecular genetic basis of murine lymphomas. (1986)

We analyzed the lymphoma susceptibility of 13 AKXD recombinant inbred mouse strains derived from AKR/J, a highly lymphomatous strain, and DBA/2J, a weakly lymphomatous strain. Of the 13 strains used, 12 showed a high incidence of lymphoma development. However, the average age at onset of lymphoma varied considerably among the different AKXD strains, suggesting that they have segregated several loci that affect lymphoma susceptibility. A relatively unambiguous classification of lymphomas was made possible by using histopathology in addition to detailed molecular characterization of rearrangements in immunoglobulin heavy and kappa light genes and in T-cell receptor beta-chain genes. Among the 12 highly lymphomatous strains, only 2 were identified that, like the parental AKR/J strain, died primarily of T-cell lymphomas. Three strains died primarily of B-cell lymphomas, and one strain primarily of myeloid lymphomas. Six strains were susceptible to both T-cell and B-cell lymphomas. Thus, these strains have segregated genes that affect both lymphoma susceptibility and lymphoma type and should prove to be useful models for studying the molecular genetic basis of murine lymphomas.
Allelic Diversity and Population Structure in<i>Oenococcus oeni</i>as Determined from Sequence Analysis of Housekeeping Genes (2004)

Oenococcus oeni is the organism of choice for promoting malolactic fermentation in wine. The population biology of O. oeni is poorly understood and remains unclear. For a better understanding of the mode of genetic variation within this species, we investigated by using multilocus sequence typing (MLST) with the gyrB, pgm, ddl, recP, and mleA genes the genetic diversity and genetic relationships among 18 O. oeni strains isolated in various years from wines of the United States, France, Germany, Spain, and Italy. These strains have also been characterized by ribotyping and restriction fragment length polymorphism (RFLP) analysis of the PCR-amplified 16S-23S rRNA gene intergenic spacer region (ISR). Ribotyping grouped the strains into two groups; however, the RFLP analysis of the ISRs showed no differences in the strains analyzed. In contrast, MLST in oenococci had a good discriminatory ability, and we have found a higher genetic diversity than indicated by ribotyping analysis. All sequence types were represented by a single strain, and all the strains could be distinguished from each other because they had unique combinations of alleles. Strains assumed to be identical showed the same sequence type. Phylogenetic analyses indicated a panmictic population structure in O. oeni. Sequences were analyzed for evidence of recombination by split decomposition analysis and analysis of clustered polymorphisms. All results indicated that recombination plays a major role in creating the genetic heterogeneity of O. oeni. A low standardized index of association value indicated that the O. oeni genes analyzed are close to linkage equilibrium. This study constitutes the first step in the development of an MLST method for O. oeni and the first example of the application of MLST to a nonpathogenic food production bacteria.
Antimutagenicity of a low molecular weight superoxide dismutase mimic against oxidative mutagens (1992)

A set of stable nitroxide free radicals that are used as spin labels have been shown to possess metal-independent superoxide dismutase-like activity. Unlike superoxide dismutase (SOD), these compounds are low molecular weight, and readily penetrate into the cell. A representative nitroxide, 4-hydroxy-2,2,6,6-tetramethylpiperidinyloxy (Tempol), was investigated for antimutagenic activity in the XPRT forward mutation assay in CHO AS52 cells. AS52 cells were exposed to hydrogen peroxide, or the hypoxanthine/xanthine oxidase superoxide generating system, in the presence or absence of 10 mM Tempol. Tempol itself was not mutagenic or toxic to AS52 cells. Tempol protected cells nearly completely from the cytotoxic and mutagenic effects of hydrogen peroxide and hypoxanthine/xanthine oxidase. We have previously shown that nitroxides do not alter the extracellular concentration of hydrogen peroxide, and that they are taken up by mammalian cells, suggesting that the antimutagenic activity of Tempol is an intracellular phenomenon.
DETECTION OF GROSS ERRORS IN NONLINEARLY CONSTRAINED DATA: A CASE STUDY (1987)

The MIMT algorithm previously developed for gross error detection in linearly constrained systems was extended to nonlinear systems. The algorithm was tested by means of computer simulation using data from an industrial grinding circuit. The overall performance of the algorithm on the nonlinear system was found to be comparable to that exhibited on a linear system of approximately the same size. The algorithm correctly detected approximately 80% of all systematic errors in the data and achieved an average reduction in total error of more than 60%. The detection rate for the more significant (gross) systematic errors was approximately 90%. These results represent the first detailed performance evaluation of a gross error detection algorithm applied to a nonlinear system of industrial significance.
Biological Nitrogen Fixation (1968)

The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous biological processes, including cell growth and fate decision, organ size ...Read More
Isosorbide Mononitrate in Heart Failure with Preserved Ejection Fraction (2015)

Patients with heart failure and a preserved ejection fraction who received isosorbide mononitrate were less active and did not have better quality of life or submaximal exercise capacity than did patients who received placebo. (Funded by the National Heart, Lung, and Blood Institute; ClinicalTrials.gov number, NCT02053493.).
Transcatheter Subendocardial Infusion (1996)

Transcatheter subendocardial infusion can be used to reversibly impair local excitability and mark an injection site fluoroscopically. Subendocardial injection of ethanol can predictably ablate a large volume of ventricular myocardium. Additional study of this system in an arrhythmia model will help to define its potential for mapping and ablation of hypotensive ventricular tachycardia.
A Personalized Stock Recommendation System using Adaptive User Modeling (2006)

In this paper, a new framework for personalized stock recommendation system based on adaptive user models is presented. The system is designed to provide personalized and appropriated information to the investors based on their personal profiles and their historical system interactions. The system components include initializing and updating user models, monitoring the interaction of the user to the system, tailoring the information to meet the user's behavior and investment styles. The system prototype was implemented in JAVA. The system evaluations were performed on both synthetic subjects and real human subjects. The results show our proposed system is able to rapidly self-adapted to provide appropriate advice to each user who has a wide variety of interest, backgrounds and expertise
A group experience (1990)

Tony Taylor, one of the winners of the Nursing Standard /BUPA Nursing Nurse 90 Awards describes his experiences of setting up a wide range of community-based groups
High <i>p</i>-type doping of ZnSe using Li3N diffusion (1994)

We have achieved a highly doped p-type ZnSe layer using a Li3N diffusion technique. The hole concentration of the p-type ZnSe layer, grown on a GaAs substrate by metalorganic vapor phase epitaxy, reached a level as high as 1017 cm−3. With the diffusion temperature of 470 °C, the resistivity of the layer is as low as 0.4 Ω cm, with hole concentration p≳9×1017 cm−3 and hole mobility μp=17 cm2/V s. We made an ohmic contact by using this p+-type ZnSe as a contact layer for p-ZnSe epilayers.
An HMM-based behavior modeling approach for continuous mobile authentication (2014)

This paper studies continuous authentication for touch interface based mobile devices. A Hidden Markov Model (HMM) based behavioral template training approach is presented, which does not require training data from other subjects other than the owner of the mobile. The stroke patterns of a user are modeled using a continuous left-right HMM. The approach models the horizontal and vertical scrolling patterns of a user since these are the basic and mostly used interactions on a mobile device. The effectiveness of the proposed method is evaluated through extensive experiments using the Toucha-lytics database which comprises of touch data over time. The results show that the performance of the proposed approach is better than the state-of-the-art method.
Syntheses, carbon-13 and proton nuclear magnetic resonance spectra of some 1,2,4-triazine 1- and 2-oxides (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSyntheses, carbon-13 and proton nuclear magnetic resonance spectra of some 1,2,4-triazine 1- and 2-oxidesRobert J. Radel, Brian T. Keen, Cindy Wong, and William W. PaudlerCite this: J. Org. Chem. 1977, 42, 3, 546–550Publication Date (Print):February 1, 1977Publication History Published online1 May 2002Published inissue 1 February 1977https://pubs.acs.org/doi/10.1021/jo00423a033https://doi.org/10.1021/jo00423a033research-articleACS PublicationsRequest reuse permissionsArticle Views175Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
APPLICATIONS OF IMPINGING-STREAMS IN CHEMICAL ENGINEERING PROCESSES—REVIEW (1987)

Various aspects of the method of impinging-streams, which proved to be one of the most efficient methods for performing the gas-solid operations in Chemical Engineering, are discussed. The aim of the review is to bring the method of impinging-streams and its possibilities to the attention of the Chemical Engineering community, to stimulate further research in the field and to encourage the technological applications of this method. KEYWORDS: Impinging streams, Impinging jets, Impingement zone, Opposed jets
Ionic Conductivity in the Metal–Organic Framework UiO‐66 by Dehydration and Insertion of Lithium <i>tert</i>‐Butoxide (2013)

Shields up! Post-synthetic modification of the secondary building units in the metal-organic framework UiO-66 (Zr6O4(OH)4(O2CR)12) by dehydration and subsequent grafting of LiOtBu yields a solid Li(+) electrolyte with a conductivity of 1.8×10(-5) S cm(-1) at 293 K. As the grafting leads to screening of the anionic charge, the activation energy for ionic conduction is significantly lower than when Li(+) is introduced through deprotonation.
Validation of an in vitro 3D bone culture model with perfused and mechanically stressed ceramic scaffold (2015)

An engineered three dimensional (3D) in vitro cell culture system was designed with the goal of inducing and controlling in vitro osteogenesis in a reproducible manner under conditions more similar to the in vivo bone microenvironment than traditional two-dimensional (2D) models. This bioreactor allows efficient mechanical loading and perfusion of an original cubic calcium phosphate bioceramic of highly controlled composition and structure. This bioceramic comprises an internal portion containing homogeneously interconnected macropores surrounded by a dense layer, which minimises fluid flow bypass around the scaffold. This dense and flat layer permits the application of a homogeneous loading on the bioceramic while also enhancing its mechanical strength. Numerical modelling of constraints shows that the system provides direct mechanical stimulation of cells within the scaffold. Experimental results establish that under perfusion at a steady flow of 2 L/min, corresponding to 3 Medium velocity 23 m/s, mouse calvarial cells grow and differentiate as osteoblasts in a reproducible manner, and lay down a mineralised matrix. Moreover, cells respond to mechanical loading by increasing C-fos expression, which demonstrates the effective mechanical stimulation of the culture within the scaffold. In summary, we provide a "proof-of-concept" for osteoblastic cell culture in a controlled 3D culture system under perfusion and mechanical loading. This model will be a tool to analyse bone cell functions in vivo, and will provide a bench testing system for the clinical assessment of bioactive bone-targeting molecules under load.
Synthesis and Properties of Organocobalt(III)octaethylporphyrins (1976)

Abstract The syntheses of alkylcobalt(III)octaethylporphyrins(OEP) via nucleophilic attack of the Co(I) complex to unsaturated compounds are reported. Olefins with an electron-withdrawing group and acetylenes react with Co(I)(OEP), whereas olefins with an electron-donating group such as propylene and cyclohexene are unreactive. A novel ring cleavage of cyclopropyl methy ketone initiated by Co(I)(OEP) affords alkylCo(III)(OEP). The reduction of cobalt(II) N-methyloctaethylporphyrin acetate results in intramolecular methyl migration from nitrogen to the central cobalt atom. Five-coordination has been established for the organocobalt(III)(OEP) complexes on the basis of their analytical, infrared and NMR data. Some anomalous behavior of the proton signals of the α-carbon atom in their NMR spectra has been discussed in terms of quadrupolar relaxation and electronegativity of the cobalt ion.
Self-Renewal of Single Mouse Hematopoietic Stem Cells Is Reduced by JAK2V617F Without Compromising Progenitor Cell Expansion (2013)

Recent descriptions of significant heterogeneity in normal stem cells and cancers have altered our understanding of tumorigenesis, emphasizing the need to understand how single stem cells are subverted to cause tumors. Human myeloproliferative neoplasms (MPNs) are thought to reflect transformation of a hematopoietic stem cell (HSC) and the majority harbor an acquired V617F mutation in the JAK2 tyrosine kinase, making them a paradigm for studying the early stages of tumor establishment and progression. The consequences of activating tyrosine kinase mutations for stem and progenitor cell behavior are unclear. In this article, we identify a distinct cellular mechanism operative in stem cells. By using conditional knock-in mice, we show that the HSC defect resulting from expression of heterozygous human JAK2V617F is both quantitative (reduced HSC numbers) and qualitative (lineage biases and reduced self-renewal per HSC). The defect is intrinsic to individual HSCs and their progeny are skewed toward proliferation and differentiation as evidenced by single cell and transplantation assays. Aged JAK2V617F show a more pronounced defect as assessed by transplantation, but mice that transform reacquire competitive self-renewal ability. Quantitative analysis of HSC-derived clones was used to model the fate choices of normal and JAK2-mutant HSCs and indicates that JAK2V617F reduces self-renewal of individual HSCs but leaves progenitor expansion intact. This conclusion is supported by paired daughter cell analyses, which indicate that JAK2-mutant HSCs more often give rise to two differentiated daughter cells. Together these data suggest that acquisition of JAK2V617F alone is insufficient for clonal expansion and disease progression and causes eventual HSC exhaustion. Moreover, our results show that clonal expansion of progenitor cells provides a window in which collaborating mutations can accumulate to drive disease progression. Characterizing the mechanism(s) of JAK2V617F subclinical clonal expansions and the transition to overt MPNs will illuminate the earliest stages of tumor establishment and subclone competition, fundamentally shifting the way we treat and manage cancers.
A First Principles Study of the Effects of Sulfur Adsorption on the Activity of Pt, Ni and Pt3Ni (2007)

Abstract not Available.
IPA-free Texturization of n-type Si Wafers: Correlation of Optical, Electronic and Morphological Surface Properties (2013)

The application of an Isopropanol(IPA)-free potassium hydroxide (KOH) solution was evaluated in order to prepare random pyramids on as-cut crystalline n-type Si wafers to reduce reflection losses of substrates for high-efficiency hetero-junction solar cells. The influence of saw damage removal and texturization processes on the resulting pyramid morphology and the corresponding interplay between optical and electronic properties are revealed. It is shown that both the depth of the saw damage etching (SDE) and the duration of the texturization etching have crucial influence on the resulting pyramid size distribution. Reflection losses can be reduced with decreasing fraction of small pyramids. By intermediate saw damage removal and texture etching times in (IPA)-free KOH solution the densities of electronic interface states were found to be strongly decreased (Dit,min < 5 10-11 cm-2eV-1), in comparison to pyramids prepared in IPA containing solutions. For the purpose of fabricating amorphous/crystalline (a-Si:H/c-Si) heterojunction solar cells the Si substrate surfaces were passivated with an intrinsic layer of amorphous silicon (a- Si:H(i)) leading to minority charge carrier lifetimes τeff of 2 to 4 ms, depending on the preceding texturization process.