gebhart/patrepeval huggingface dataset:
The search for<i>Brachyspira</i>outer membrane proteins that interact with the host (2001)

Abstract Little is known about the outer membrane structure of Brachyspira hyodysenteriae and Brachyspira pilosicoli or the role of outer membrane proteins (OMPs) in host colonization and the development of disease. The isolation of outer membrane vesicles from B. hyodysenteriae has confirmed that cholesterol is a significant outer membrane constituent and that it may impart unique characteristics to the lipid bilayer structure, including a reduced density. Unique proteins that have been identified in the B. hyodysenteriae outer membrane include the variable surface proteins (Vsp) and lipoproteins such as SmpA and BmpB. While the function of these proteins remains to be determined, there is indirect evidence to suggest that they may be involved in immune evasion. These data may explain the ability of the organism to initiate chronic infection. OMPs may be responsible for the unique attachment of B. pilosicoli to colonic epithelial cells; however, the only B. pilosicoli OMPs that have been identified to date are involved in metabolism. In order to identify further B. pilosicoli OMPs we have isolated membrane vesicle fractions from porcine strain 95–1000 by osmotic lysis and isopycnic centrifugation. The fractions were free of contamination by cytoplasm and fla-gella and contained outer membrane. Inner membrane contamination was minimal but could not be completely excluded. An abundant 45-kDa, heat-modifiable protein was shown to have significant homology with B. hyodysenteriae Vsp, and monoclonal antibodies were produced that reacted with five B. pilosicoli-specific membrane protein epitopes. The first of these proteins to be characterized is a unique surface-exposed lipoprotein.
Commentary: The Case for Routine Maintenance of Dental Implants (2013)

The large majority of dental implants are successful over the long term. Failure is usually associated with infection, trauma, inflammation, or a combination of these factors. Early identification and appropriate treatment can identify and eliminate these problems in the majority of cases. Thus routine implant maintenance structured along the guidelines for patients with periodontal diseases is recommended.
Growing network with local rules: Preferential attachment, clustering hierarchy, and degree correlations (2003)

The linear preferential attachment hypothesis has been shown to be quite successful in explaining the existence of networks with power-law degree distributions. It is then quite important to determine if this mechanism is the consequence of a general principle based on local rules. In this work it is claimed that an effective linear preferential attachment is the natural outcome of growing network models based on local rules. It is also shown that the local models offer an explanation for other properties like the clustering hierarchy and degree correlations recently observed in complex networks. These conclusions are based on both analytical and numerical results for different local rules, including some models already proposed in the literature.
Speaker independent acoustic modeling using speaker normalization (2002)

This paper proposes a novel speaker-independent (SI) modeling for spontaneous speech data from multiple speakers. The SI acoustic model parameters are estimated by individual training for inter-speaker variability and for intraspeaker phonetically related variation in order to obtain a more accurate acoustic model. The linear transformation technique is used for the speaker normalization to extract intra-speaker phonetically related variation and also is used for the re-estimation of inter-speaker variability. The proposed modeling is evaluated for a Japanese spontaneous speech data, using continuous density mixture Gaussian HMMs. Experimental results from the use of proposed acoustic model show that the reductions in word error rate can be achieved over the standard SI model regardless the type of acoustic model used.
Electrochemical Reduction of NOx at Intermediate Temperatures Using a Proton-Conducting In3 + -Doped SnP2O7 Electrolyte (2006)

-doped was used as the electrolyte in an electrochemical cell for the reduction of NO between 150 and 300°C in the presence of excess . NO was reduced to at a cathode when current was applied to the cell. The electrocatalytic activity of the cathode for the reduction of NO was shown to be highest at 250°C. The addition of Ba species (an oxide∕carbonate mixture) to the cathode further promoted the reduction of NO by adsorbing NO more selectively than on the surface. A resulting current efficiency of 5.81% was achieved in a 2% atmosphere.
Heat pipe heat transport system for the Stirling Space Power Converter (SSPC) (1992)

Life issues relating to a sodium heat pipe heat transport system are described. The heat pipe system provides heat, at a temperature of 1050 K, to a 50 kWe Stirling engine/linear alternator power converter called the Stirling Space Power Converter (SSPC). The converter is being developed under a National Aeronautics and Space Administration program. Since corrosion of heat pipe materials in contact with sodium can impact the life of the heat pipe, a literature review of sodium corrosion processes was performed. It was found that the impurity reactions, primarily oxygen, and dissolution of alloy elements were the two corrosion process likely to be operative in the heat pipe. Approaches that are being taken to minimize these corrosion processes are discussed.
Constitutive presentation of dominant epitopes from endogenous naturally processed self-beta 2-microglobulin to class II-restricted T cells leads to self-tolerance. (1995)

The mouse beta 2-microglobulin (m beta 2-m) peptide corresponding to residues 25-40 binds to the MHC class II molecules I-Ad and I-Ed and is immunogenic in BALB/c beta 2-m-deficient but not in normal BALB/c mice. The self-m beta 2-m peptide 25-40 is presented by both I-Ad and I-Ed class II molecules as demonstrated by the activation of T cell hybridomas specific for this sequence obtained from beta 2-m knock-out mice. By analyzing the effect of N- and C-terminal truncations of m beta 2-m25-40 on binding to class II molecules and on activation of T cell hybridomas, the minimum epitopes recognized by I-Ad and I-Ed-restricted T cells are included within amino acid residues 26-39 and 24-36, respectively. Both sets of T hybridomas are also activated by the corresponding naturally processed self-epitope presented by APC from BALB/c mice and from other H-2d strains, irrespective of their Mls phenotype. Therefore, the sequence 25-40 contains dominant naturally processed self-epitopes of the mouse beta 2-m. Processing of endogenous m beta 2-m is sensitive to protease inhibitors and lysosomotropic amines, and is not caused by reuptake of shed or released protein. These results indicate that self-beta 2-m-peptide-MHC class II complexes derive from constitutive processing of the endogenous intracellular pool of m beta 2-m in an acidic endosomal compartment. Antigenic complexes between m beta 2-m peptides and I-Ad or I-Ed class II molecules are constitutively expressed by APC of different tissues, including the thymus, and they are able to induce T cell tolerance, as shown by the lack of T cell response to m beta 2-m25-40 in BALB/c mice.
The Preparation and Properties of Some Cyclic β-Diketone Diimines (1973)

The condensation reaction between a series of aliphatic diamines and a series of five- and six-membered cyclic β-diketones to form Schiff bases was investigated. Mass spectral data show that reaction occurred on the side-chain carbonyl except where steric hindrance forced condensation to occur on the ring carbonyl. N.m.r. studies show that these Schiff bases exist primarily in the ketamine form in solution, irrespective of the solvent. I.r. data confirm this. The preparation of a number of Cu(II) and Ni(II) complexes from some of the ligands is also described.
New Directions in ASTHMA Management (1999)

Cheryl Owen is a care manager for the Disease Specific Case Management Department at the National Jewish Medical and Research Center, Denver, CO.
Evidence of Aggregate Formation for 2,5-Dialkylpoly(<i>p</i>-phenyleneethynylenes) in Solution and Thin Films (1998)

The absorptive and emissive behavior of four highly fluorescent bisalkyl-substituted poly(p-phenyleneethynylenes) (R = hexyl, dodecyl, 2-(ethyl)hexyl, and 3,5,5-trimethylhexyl) was examined. Aggregate and excimer formation was seen in solution and in the solid state by a combination of absorption and fluorescence spectroscopy in solvent/nonsolvent (chloroform/methanol) mixtures and in thin films. The aggregates were identified by the occurrence of a sharp absorption centered at 440 nm, undetectable in dilute chloroform solution, and a broad emission at 504 nm. The average size of the aggregate formed in chloroform/methanol solvent mixtures must exceed 1.5 μm, as was evidenced in filtering-experiments utilizing a set of membranes with different pore sizes to successively remove smaller aggregates.
Design and Experimental Study of a VCM-Based Whole-Spacecraft Vibration Isolation System (2018)

Spacecraft are subjected to various dynamic loads due to shock from stage and fairing separations, resonant burn of the rocket motor, pressure oscillation in liquid engines, wind and gust, etc. These dynamic loads are very detrimental to spacecraft components, electronics, and instruments. Hence, for the successful launching of a spacecraft, a whole-spacecraft vibration isolator (WSVI) is often applied to the launching process. In this paper, a novel active whole-spacecraft isolation system based on voice coil motors (VCMs) is designed, fabricated, and tested. The proposed WSVI system is composed of VCMs, supporting leaf springs, and actuator supports. It is nonintrusive to existing hardware, lightweight, and small, and it satisfies the design requirement of vibration isolation without changing the payload adaptor fitting structure. The characteristics of the spacecraft with and without the isolation system were tested. A controller design method based on the system identification and H∞ control law is proposed. A prototype was designed and tested to validate the isolation performance of the proposed system. Experimental results show that the novel WSVI system is valid for significant reduction of the amplitude of the spacecraft’s vibration response.
CXC chemokine receptor 3 expression on CD34+hematopoietic progenitors from human cord blood induced by granulocyte-macrophage colony-stimulating factor: chemotaxis and adhesion induced by its ligands, interferon γ–inducible protein 10 and monokine induced by interferon γ (2000)

CXC chemokine receptor 3 (CXCR3), which is known to be expressed predominately on memory and activated T lymphocytes, is a receptor for both interferon γ (IFN-γ)–inducible protein 10 (γIP-10) and monokine induced by IFN-γ (Mig). We report the novel finding that CXCR3 is also expressed on CD34+ hematopoietic progenitors from human cord blood stimulated with granulocyte-macrophage colony-stimulating factor (GM-CSF) but not on freshly isolated CD34+ progenitors. Freshly isolated CD34+progenitors expressed low levels of CXCR3 messenger RNA, but this expression was highly up-regulated by GM-CSF, as indicated by a real-time quantitative reverse transcriptase–polymerase chain reaction technique. γIP-10 and Mig induced chemotaxis of GM-CSF–stimulated CD34+ progenitors by means of CXCR3, since an anti-CXCR3 monoclonal antibody (mAb) was found to block γIP-10–induced and Mig-induced CD34+ progenitor chemotaxis. These chemotactic attracted CD34+ progenitors are colony-forming units—granulocyte-macrophage. γIP-10 and Mig also induced GM-CSF–stimulated CD34+ progenitor adhesion and aggregation by means of CXCR3, a finding confirmed by the observation that anti-CXCR3 mAb blocked these functions of γIP-10 and Mig but not of chemokine stromal cell–derived factor 1α. γIP-10–induced and Mig-induced up-regulation of integrins (CD49a and CD49b) was found to play a crucial role in adhesion of GM-CSF–stimulated CD34+progenitors. Moreover, γIP-10 and Mig stimulated CXCR3 redistribution and cellular polarization in GM-CSF–stimulated CD34+progenitors. These results indicate that CXCR3–γIP-10 and CXCR3–Mig receptor-ligand pairs, as well as the effects of GM-CSF on them, may be especially important in the cytokine/chemokine environment for the physiologic and pathophysiologic events of differentiation of CD34+ hematopoietic progenitors into lymphoid and myeloid stem cells, subsequently immune and inflammatory cells. These processes include transmigration, relocation, differentiation, and maturation of CD34+ hematopoietic progenitors.
An Agent-Based Framework for Matching Buyers and Sellers (2008)

This paper explores issues of electronic commerce as a key enabler to promote trade between buyers and sellers. The broker is processed to match buyers and sellers, which is significant in prompting the transactions between the two sides. This paper proposes an agent-based framework for matching buyers and sellers and uses the multi-objective optimization model to match sellers and buyers. The framework is processed in three layers: the interface layer, the matching layer and the database layer. The interface layer consists of buyer agents, seller agents and a broker agent. The matching layer is mainly to find the appropriate sellers to buyers. Based on the framework, a prototype system has been designed to illustrate the effectiveness of the approach.
Delta Doped $\beta$ -Ga2O3 Field Effect Transistors With Regrown Ohmic Contacts (2018)

We report silicon delta-doped β-Ga <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> metal semiconductor field effect transistors (MESFETs) with source-drain ohmic contacts formed by patterned regrowth of n-type Ga <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> . We show that regrown n-type contacts can enable a lateral low-resistance contact to the two-dimensional electron gas channel, with contact resistance lower than 1.5 Ω-mm. The fabricated MESFET has a peak drain current (I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">D,MAX</sub> ) of 140 mA/mm, transconductance (g <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">m</sub> ) of 34 mS/mm, and 3-terminal off-state breakdown voltage of 170 V. The proposed device structure could provide a promising path towards vertically scaled β-Ga <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> field effect transistors.
Tracking an LED array transmitter for visible light communications in the driving situation (2010)

In this paper, we discuss on a decoding algorithm for visible light communication systems in the driving situation using an LED array transmitter and a high-speed camera receiver. We propose an LED array detection method using M-sequence and an LED array tracking method using inverted signals. We confirm that we can distinguish LED array candidates correctly with M-sequence. We also confirm that we can suppress the flicker of the LED and improve the data rate as compared with the previous method.
Evolution in Banking Supervision (2000)

Banking supervision must keep pace with technical innovations in the banking industry. The international Basel Committee on Banking Supervision currently is reviewing public comments on its proposed new method for judging whether a bank maintains enough capital to absorb unexpected losses. This Economic Commentary explains how existing standards became obsolete and describes the new plan.
Effects of pore morphology and size on antimicrobial activity of chitosan/poly(ethylene glycol) diacrylate macromer semi‐<scp>IPN</scp>hydrogels (2015)

ABSTRACT The objective of this study was to obtain antibacterial active chitosan/poly(ethylene glycol) diacrylate macromere (CS/PEGM) semi‐IPN hydrogels near a neutral pH level by changing their pore size and morphology. These hydrogels were prepared from CS and PEGM with different molecular weights in the presence of pore‐forming agents, poly (ethylene glycol) (PEG) or sodium bicarbonate (NaHCO 3 ), by using two different initiator system, namely chemical or UV. A combination of CS with PEG or NaHCO 3 in the presence of PEGM could be able to create desired pore formation in both initiator systems. The antibacterial activity of hydrogels changed with the molecular weight (g/mol) of PEGM in the order 2000>400>8000. A chemical initiation system was found more suitable than the UV initiation system for antibacterial activity. Hydrogels showing the highest antibacterial activity on Staphylococcus aureus and Escherichia coli have medium or distributed pore size and interconnected pores. Hydrogels prepared with PEGM ( M n : 2000 g/mol) were proposed for antibacterial wound dressing and soft tissue regeneration applications owing to their antibacterial activity and elastic modulus. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132 , 42707.
Helicobacter pylori-induced gastritis in the domestic cat (1995)

Helicobacter pylori has been cultured from the inflamed gastric mucosae of naturally infected cats; the lesions in H. pylori-infected cat stomachs mimic many of the features seen in H. pylori-infected human stomachs. To determine whether H. pylori-negative specific-pathogen-free cats with normal gastric mucosae were susceptible to colonization by this bacterium and whether gastritis developed after infections, four H. pylori-negative cats treated with cimetidine were orally dosed three times with 3 ml (1.5 x 10(8) CFU/ml) of H. pylori every 4 days. All four cats became persistently colonized as determined by gastric cultures and PCRs from serial gastric biopsy samples and necropsy samples at 7 months postinfection. H. pylori was not isolated from the two control cats, nor were their gastric tissues positive by PCR; one of the two cats had a few focal lymphocytic aggregates in the body submucosa, whereas the second cat had a normal gastric mucosa. All four H. pylori-infected cats had multifocal gastritis consisting of lymphoid aggregates plus multiple large lymphoid nodules, which were most noticeable in the antral mucosa. In addition, one H. pylori-infected cat had a moderate diffuse infiltration of polymorphonuclear leukocytes in the subglandular region of the antrum. H. pylori-like organisms were focally distributed in glandular crypts of the antrum. Two of the H. pylori-infected cats had significant (eightfold) increases over baseline in levels of immunoglobulin G H. pylori serum antibody. The H. pylori isolates from the four experimentally infected cats had restriction fragment length polymorphism patterns specific for the flaA gene that were identical to those of the inoculating strain. H. pylori readily colonizes the cat stomach and produces persistent gastritis.
A new method for measuring power system frequency (1999)

The algorithms of numerical protective relays are very sensitive to variations in the power system frequency during operation. Even slight changes of the power frequency can lead to large calculation errors in the values for impedances, the power factor, etc. Implementing an adaptive sampling rate requires knowing the actual system frequency at all times with high accuracy. A new frequency measurement method has been successfully implemented. Since the method is not dependent upon zero-crossings of the measured current, it can calculate the frequency after every sample. In addition, the necessary signal-window is approximately 3 cycles, which means that the calculation is faster than all classical methods. The new method has made possible the development of a full-featured generator protection relay that can operate over a frequency range of 15 Hz-70 Hz. The accuracy of the frequency calculation is better then 10 mHz for a nominal frequency of 60 Hz.
Two distinct receptors are activated by arecoline on cockroach sixth abdominal ganglion DUM neurones (1994)

ABSTRACT During the last decade, extensive biochemical and electrophysiological studies have been performed to characterize the pharmacological properties of cholinergic receptors of insect neurone somata (Sattelle, 1985; Breer and Sattelle, 1987; Benson, 1992). Although most of these studies have been focused on the pharmacological characterization of the cell body nicotinic receptors (Lane et al. 1982; Harrow and Sattelle, 1983; David and Sattelle, 1984; Benson, 1992), evidence for a population of acetylcholine (ACh) receptors exhibiting muscarinic and ‘mixed’ (nicotinic/muscarinic) properties has been reported on insect neurone somata (Benson and Neumann, 1987; Knipper and Breer, 1988; Benson, 1989, 1992, 1993; Trimmer and Weeks, 1989; David and Pitman, 1990, 1992, 1993). One group of insect neurones, called dorsal unpaired median (DUM) neurones, expresses functional cholinergic receptors that differ from the classic vertebrate ACh receptors in that, although DUM neurones were sensitive to ACh, the nicotinic and/or muscarinic nature of these receptors has not been resolved since the cholinergic antagonists α-bungarotoxin and atropine were relatively ineffective in blocking the ACh response (Goodman and Spitzer, 1980; Lane et al. 1982; Lapied et al. 1990). However, using a range of cholinergic antagonists known to be selective for vertebrate ACh receptors, it has recently been possible to demonstrate the diversity of functional ACh receptors; these include nicotinic, ‘mixed’ and muscarinic receptors mediating specific responses elicited by different cholinergic agonists, such as nicotine, muscarine, oxotremorine and McN-A-343, on both isolated and in situ DUM neurones (Lapied et al. 1990, 1992; Bai et al. 1992). Extending these studies, we report in this paper that another cholinergic ligand, arecoline, which is known to act preferentially as a muscarinic agonist in vertebrate preparations (Wess et al. 1990), induced a complex response mediated by both nicotinic and muscarinic receptors on DUM neurones.
<title>Zoom lens without focus-breathing phenomena</title> (2001)

Assuming that exit pupil position is fixed, it is presented a zoom lens having a focusing mechanism which does not give rise to any changes in the angular field of view. A frontal part set in front of the zooming part consists of two movable components for focusing. The paraxial condition in which no focus breathing phenomena exist is, in general, derived. Explicit expressions of component-displacement are obtained together with the relation to one-movable component focusing method. According to the analysis, a zoom lens is designed to show the usefulness of the analysis.
Sidney J. Catts: The Road to Power (1970)

The South produced a bumper crop of political demagogues between 1890 and 1920. This unparalleled but dubious array of luminaries included James E. Ferguson of Texas, Huey Long of Louisiana, James K. Vardaman and Theodore Bilbo of Mississippi, Tom Heflin of Alabama, Tom Watson of Georgia, Cole Blease, “Cotton” Ed Smith, and Ben Tillman of South Carolina, as well as many others. These politicos broke the back of conservative Bourbonism with their emotional appeals to the religious and racial intolerance of the newly powerful masses of voters. Once in office they frequently championed social and economic reform such as the abolition of the convict lease system, restriction of child labor, ameliorative labor legislation, woman suffrage, shifting tax burdens to corporations, railroad regulation, expanded educational opportunities, and many other creative measures.