gebhart/patrepeval huggingface dataset:
High Prevalence of Human Papillomavirus Infections in Urine Samples from Human Immunodeficiency Virus-Infected Men (2005)

Infection with human immunodeficiency virus (HIV) and the resulting immunosuppression are associated with an increased risk for human papillomavirus (HPV) persistence and related malignancies. In the present study we investigated the prevalence of HPV in urine samples from 104 HIV-infected men with low CD4+ cell counts (<100 per mm(3)) and 115 urine samples from HIV-negative men. A high prevalence of HPV DNA (39.4%) was found in the HIV patients. Most of the HPV types were high risk (81.4%), with HPV 52 as the most prevalent type (12.5%), followed by HPV 18 (6.7%), HPV 35 (5.8%), and HPV 70 (4.8%). Multiple HPV genotypes were observed in 17 (41%) of the 41 HPV- and HIV-positive men. In contrast, only 11 (9.6%) HPV DNA-positive cases were observed among the 115 HIV-uninfected men, and 3 (27.3%) contained multiple genotypes. Quantitative analyses indicated that the HPV viral load, as measured in urine samples, is significantly higher in HIV-positive men compared to HIV-negative men. In the present study we show that urine samples are useful for detecting HPV DNA, there is a high prevalence of HPV in HIV-positive men, and the HPV viral load is substantially higher in HIV-positive than in HIV-negative men. More studies are needed to evaluate the risk and natural development of HPV-related malignancies in HIV-positive men.
Cell Surface Expression of the Melanocortin-4 Receptor Is Dependent on a C-terminal Di-isoleucine Sequence at Codons 316/317 (2003)

Loss-of-function mutations in the human melanocortin-4 receptor (MC4R) are associated with obesity. Previous work has implicated a C-terminal di-isoleucine motif at residues 316/317 in MC4R cell surface targeting. It was therefore of interest to examine function and cell surface expression of an MC4R mutation found in an obese proband in which one of these isoleucines was substituted by threonine (I317T). Single mutant (I316T or I317T) and double mutant (I316T,I317T) forms of MC4R were constructed by oligonucleotide-directed mutagenesis and tested for function and cell surface expression in transfected cells. Function was assessed using assays for agonist, [Nle(4)-d-Phe(7)]alpha-melanocyte-stimulating hormone (NDP-alpha-MSH) or forskolin-stimulated cAMP accumulation. Cell surface expression was determined by whole-cell binding of [(125)I]NDP-alpha-MSH, fluorescence immunocytochemistry and fluorescence-activated cell sorting. Maximal cAMP generation of the single mutants was reduced by 40% of wild-type receptor; the double mutant further reduced function to 40% of control, effects that were mirrored by decreases in cell-surface expression. Quantitative RT-PCR showed that, relative to wild-type receptor, transcript levels for the mutated receptors were not reduced. The results further implicate the C-terminal di-isoleucines in cell surface expression of MC4R and suggest that mutations of residues 316 or 317 would predict MC4R hypofunction.
Transcutaneous Nitroglycerine Enhances the Quality of Erections in Impotent Men. Results of a Controlled Trial (1987)

No AccessJournal of Urology1 Jun 1987Transcutaneous Nitroglycerine Enhances the Quality of Erections in Impotent Men. Results of a Controlled Trial J. Owen, M. Condra, P. Phillips, D. Surridge, J. Fenemore, and A. Morales J. OwenJ. Owen More articles by this author , M. CondraM. Condra More articles by this author , P. PhillipsP. Phillips More articles by this author , D. SurridgeD. Surridge More articles by this author , J. FenemoreJ. Fenemore More articles by this author , and A. MoralesA. Morales More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)75542-5AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Transcutaneous Nitroglycerine Enhances the Quality of Erections in Impotent Men. Results of a Controlled Trial." The Journal of Urology, 137(6), p. 201A © 1987 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byAboseif S, Breza J, Bosch R, Benard F, Stief C, Stackl W, Lue T and Tanagho E (2018) Local and Systemic Effects of Chronic Intracavernous Injection of Papaverine, Prostaglandin E1, and Saline in PrimatesJournal of Urology, VOL. 142, NO. 2 Part 1, (403-408), Online publication date: 1-Aug-1989.Owen J, Saunders F, Harris C, Fenemore J, Reid K, Surridge D, Condra M and Morales A (2018) Topical Nitroglycerin: A Potential Treatment for ImpotenceJournal of Urology, VOL. 141, NO. 3 Part 1, (546-548), Online publication date: 1-Mar-1989. Volume 137 Issue 6 June 1987 Page: 201A Advertisement Copyright & Permissions© 1987 by The American Urological Association Education and Research, Inc.Metrics Author Information J. Owen More articles by this author M. Condra More articles by this author P. Phillips More articles by this author D. Surridge More articles by this author J. Fenemore More articles by this author A. Morales More articles by this author Expand All Advertisement PDF downloadLoading ...
Dysregulation of microRNA‐204 mediates migration and invasion of endometrial cancer by regulating FOXC1 (2011)

MicroRNAs (miRNAs) regulate mRNA stability and protein expression, and certain miRNAs have been demonstrated to act either as oncogenes or tumor suppressors. Differential miRNA expression signatures have been documented in many human cancers but the role of miRNAs in endometrioid endometrial cancer (EEC) remains poorly understood. This study identifies significantly dysregulated miRNAs of EEC cells, and characterizes their impact on the malignant phenotype. We studied the expression of 365 human miRNAs using Taqman low density arrays in EECs and normal endometriums. Candidate differentially expressed miRNAs were validated by quantitative real-time PCR. Expression of highly dysregulated miRNAs was examined in vitro through the effect of anti-/pre-miRNA transfection on the malignant phenotype. We identified 16 significantly dysregulated miRNAs in EEC and 7 of these are novel findings with respect to EEC. Antagonizing the function of miR-7, miR-194 and miR-449b, or overexpressing miR-204, repressed migration, invasion and extracellular matrix-adhesion in HEC1A endometrial cancer cells. FOXC1 was determined as a target gene of miR-204, and two binding sites in the 3'-untranslated region were validated by dual luciferase reporter assay. FOXC1 expression was inversely related to miR-204 expression in EEC. Functional analysis revealed the involvement of FOXC1 in migration and invasion of HEC1A cells. Our results present dysfunctional miRNAs in endometrial cancer and identify a crucial role for miR-204-FOXC1 interaction in endometrial cancer progression. This miRNA signature offers a potential biomarker for predicting EEC outcomes, and targeting of these cancer progression- and metastasis-related miRNAs offers a novel potential therapeutic strategy for the disease.
When Dukes Were Two a Penny (2004)

Details of the legal entanglements which followed the death of Edwardian London furniture dealer Thomas Charles Druce in 1864 are presented. The family members, living as far as Australia, involved in the claim to the title of 'Duke' and the family fortune bequeathed by the deceased are discussed.
Pharmacotherapy for benign prostatic hyperplasia. (1994)

Benign prostatic hyperplasia is a benign neoplasm of the prostate seen in men of advancing age. Microscopic evidence of the disorder is seen in about 70% of men by 70 years of age, whereas symptoms requiring some form of surgical intervention occur in 30% of men during their lifetime. Although the exact cause of benign prostatic hyperplasia is not clear, it is well recognized that high levels of intraprostatic androgens are required for the maintenance of prostatic growth. In recent years, extensive surveys of patients undergoing transurethral resection of the prostate reveal an 18% incidence of morbidity that has essentially not changed in the past 30 years. This procedure is also the second highest reimbursed surgical therapy under Medicare. These findings have resulted in an intensive search for alternative therapies for prostatic hyperplasia. An alternative that has now been well defined is the use of alpha-adrenergic blockers to relax the prostatic urethra. This is based on findings that a major component of benign prostatic hyperplasia symptoms is spasm of the prostatic urethra and bladder neck, which is mediated by the alpha-adrenergic nerves. A second approach is to block androgens involved in maintaining prostate growth. Several such drugs are now available for clinical use, and we discuss their side effects and use. We also include the newer recommendations on evaluating benign prostatic hyperplasia that are cost-effective yet comprehensive.
A Method for Segment Based Surface Reconstruction from Discrete Inclination Values (2014)

Object orientation tracking in local reference frame can serve as a useful tool in fields such as surface shape recognition. Often measurement methods provide incomplete data about object orientation. In this paper a method is proposed for selection of surface segment direction when only inclination levels of each segment are known. Method is applicable in cases when some additional constraints can be applied to the surface, such as limited flexion and segment layout. During surface model approximation a specially adapted exhaustive search algorithm is used to find the most appropriate segment direction angle to satisfy physical constraints of the surface. This method proved to significantly increase approximation precision of non-trivial surfaces. DOI: http://dx.doi.org/10.5755/j01.eee.20.2.6380
Poly(thioether)s from Closed-System One-Pot Reaction of Carbonyl Sulfide and Epoxides by Organic Bases (2019)

The synthesis of poly(thioether), a highly desired sulfur-containing polymer, is still a key challenge. Herein, we report a simple and facile approach to poly(thioether)s by closed-system one-pot reaction of carbonyl sulfide (COS) and epoxides. This route underwent the coupling reaction of COS with epoxides, followed by decarboxylative ring-opening polymerization (ROP) of the generated mixed cyclic thiocarbonates with releasing of CO<sub>2</sub> and a little bit of COS. Organic base was used as catalyst and initiator in the two steps, respectively. The oxygen/sulfur exchange reaction was driven by successive regioselective elementary reactions and spontaneous releasing of CO<sub>2</sub> (COS), leading to the sulfur atom of COS transferring to poly(thioether)s, which was well demonstrated by DFT studies. This work provides an easy-to-handle, metal-free route to poly(thioether)s bearing diverse structures by using readily available chemicals.
Real Time Sound Processing and Synthesis on Multiple DSPs Using the Music Kit and the Ariel Quint Processor (1993)

This paper is an update on the 4.0 release of the Music Kit, including recent work in real-time sound processing and porting to multipleDSP architectures such as the Ariel QuintProcessor.
Magnetic Resonance Imaging of Cutaneous Melanocytic Lesions (1989)

This is the first literature report on magnetic resonance imaging (MRI) examination of cutaneous melanocytic or any other type of skin lesions. Good resolution, clinically useful MRI scans of a congenital nevus and a metastatic melanoma to the skin are presented. The potential usefulness of MRI technique to physicians dealing with cutaneous disease is discussed.
Treatments that enhance physical properties of wood (1987)

This paper was prepared for anyone who wants to know more about enhancing wood's physical properties, from the amateur wood carver to the president of a forest products company.
Food for Thought: Fluctuations in Brain Extracellular Glucose Provide Insight into the Mechanisms of Memory Modulation (2002)

Extensive evidence indicates that peripheral or direct central glucose administration enhances cognitive processes in rodents and humans. These behavioral findings suggest that glucose acts directly on the brain to regulate neural processing, a function that seems incompatible with the traditional view that brain glucose levels are high and invariant except under extreme conditions. However, recent data suggest that the glucose levels of the brain's extracellular fluid are lower and more variable than previously supposed. In particular, the level of glucose in the extracellular fluid of a given brain area decreases substantially when a rat is performing a memory task for which the brain area is necessary. Together with results identifying downstream effects of such variance in glucose availability, the evidence leads to new thinking about glucose regulation of brain functions including memory.
Similar breast cancer cell contamination of single-day peripheral-blood progenitor-cell collections obtained after priming with hematopoietic growth factor alone or after cyclophosphamide followed by growth factor. (1996)

In patients with advanced breast cancer responsive to cytotoxic chemotherapy, tumor-cell contamination is not increased in PBPC collected after 5 or 7 days priming with G-CSF and appears similar to that seen when PBPC are primed with cyclophosphamide followed by GM-CSF.
A 1.75 V rail-to-rail CMOS op amp (2002)

In this paper, a low voltage CMOS op amp, that can operate from a single 1.75 V supply voltage is presented. The op amp-has the capability of handling input signals exceeding both the positive and the negative supply rails. This is achieved by connecting n- and p-type differential pairs in parallel. The transconductance (g/sub m/) of the op amp is kept constant within 15% in the entire input common mode range. Composite transistors are employed as tail current sources of the differential pairs to improve the common mode and the power supply rejection ratios. The output stage is also implemented by composite transistors achieving high gain from a single stage while keeping the output signal swing high. The op amp was fabricated in the standard MOSIS p-well 2 /spl mu/m CMOS process. The op amp can operate with supply voltages down to 1.75 V. 80 dB DC gain and 10 MHz unity gain frequency with 8 pF load capacitance are realizable. Input signals can exceed both supply rails and the output signals can swing within 200 mV from each rail.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A new on-line subspace-based identification algorithm for multivariable Hammerstein models (2008)

This paper presents a new on-line subspace-based identification algorithm for multivariable nonlinear systems modeled with Hammerstein model structure. The developed algorithm makes use of the subspace identification method via principal component analysis (SIMPCA) to estimate the Hammerstein linear dynamic block. Then, A genetic algorithm (GA) is utilized to optimally estimate the nonlinear mapping due to the Hammerstein nonlinear block by a set of radial basis functions (RBFs). A new approach based on a sliding data block window is developed to facilitate the on-line implementation of the proposed identification algorithm. The performance of the proposed algorithm is evaluated on a simulated binary distillation column benchmark problem with complicated multivariable nonlinear dynamics. The obtained results demonstrate the effectiveness of the proposed algorithm.
Luminescent Mononuclear and Binuclear Cyclometalated Palladium(II) Complexes of 6-Phenyl-2,2‘-bipyridines:  Spectroscopic and Structural Comparisons with Platinum(II) Analogues<sup>1</sup><sup>,</sup><sup>2</sup> (1999)

The mononuclear cyclometalated Pd(II) complexes [Pd(L1)X] (HL1 = 6-phenyl-2,2'-bipyridine; X = Cl, la; Br, 1b; I, 1c), [Pd(L1)PPh3]+ (1d), [Pd(L2-5)Cl] [2a-5a, HL2-5 = 4-(aryl)-6-phenyl-2,2'-bipyridine; aryl = phenyl (2), 4-chlorophenyl (3), 4-tolyl (4), 4-methoxyphenyl (5)] and the binuclear derivatives [Pd2(L1-5)2(mu-dppm)]2+ (1e-5e, dppm = bis(diphenylphosphino)methane) and [Pd2(L1)2(mu-dppCs)]2+, (1f, dppC5 = 1,5-bis(diphenylphosphino)pentane) were prepared. The crystal structures of 1d(ClO4), 1e(ClO4)2 x DMF, and 2e(ClO4)2 have been determined by X-ray crystallography. The magnitude of the Pd-Pd distances in le and 2e (3.230(1) and 3.320(2) A, respectively) suggest minimal metal-metal interaction, although pi-stacking of the aromatic ligands (interplanar separations 3.34 and 3.35 A, respectively) is evident. All complexes display low-energy UV absorptions at lambda approximately 390 nm, which are tentatively assigned to 1MLCT transitions; red shifts resulting from Pd-Pd interactions in the binuclear species are not apparent. The complexes in this work are non-emissive at 298 K, but the cationic derivatives exhibit intense luminescence at 77 K. The structured emissions of 1d and 1f in MeOH/EtOH glass (lambdamax 467-586 nm) and all cationic species in the solid state (lambdamax 493-578 nm) are assigned to intraligand excited states. Complexes le-5e display dual emissions in MeOH/EtOH glass at 77 K, and the broad structureless bands at lambdamax 626-658 nm are attributed to pi-pi excimeric IL transitions. A comparison between the photophysical properties of Pd(II) and Pt(II) congeners is presented.
Quantification of Riding Performance and Mental Stress Level when Using Advanced Driver Assistance System for Powered Two-Wheelers (2019)

In recent years, ICT (Information and Communication Technologies) such as V2I (Vehicleto- Infrastructure), V2V (Vehicle-to-Vehicle) are being actively developed for driving safety systems across the world. In the future, ADAS (Advanced Driver Assistance System) using ICT and various kinds of sensors will be more implemented on PTW (Powered Two-wheeler) and introducing pace also will be accelerated. However, ADAS such as alarm systems can increase the level of mental stress of the four-wheeler drivers and it can be more critical for PTW riders. Therefore, we propose a method of quantifying the riding performance and mental stress level of PTW riders. In this study, we investigated the riders riding behaviors and mental stress using riding simulator (n = 7, mean age = 24.57). The riding performance was quantified as a single indicator, the mental stress level was assumed the normalized EDA signal when riders encountered a risky situation. As a result, the average mental stress level slightly increased when using the system, but there was no significant difference (t (20) = - 1.366, p=0.187). However, the riding performance improved when using the system (t (20) = -5.996, p<0.001).
Population dynamics and antimicrobial resistance of the most prevalent poultry-associated Salmonella serotypes (2016)

Salmonella spp. is the most predominant bacterial cause of foodborne gastroenteritis in humans. Due to the risk of human infection associated with poultry products and the prevalence of antimicrobial resistance, Salmonella also poses a significant challenge to commercial poultry production. During the last decade (2002 to 2012), the 12 most prevalent poultry-associated Salmonella serotypes (MPPSTs) were frequently and consistently isolated from poultry products in the United States. These MPPSTs and their percent prevalence in poultry products include Kentucky (4%), Enteritidis (2%) Heidelberg (2%), Typhimurium (2%), S. I 4,[5],12:i:- (0.31%), Montevideo (0.20%), Infantis (0.16%) Schwarzengrund (0.15%), Hadar (0.15%), Mbandaka (0.13%), Thompson (0.12%), and Senftenberg (0.04%). All MPPSTs except Kentucky are among the top 30 clinically significant serotypes that cause human illnesses in the United States. However with the exception of a few widely studied serotypes such as S. Enteritidis and Typhimurium, the ecology and epidemiology of the majority of MPPSTs still remain poorly investigated. Published data from the United States suggests that MPPSTs such as Heidelberg, Typhimurium, Kentucky, and Sentfenberg are more likely to be multi-drug resistant (MDR, ≥3 antimicobial classes) whereas Enteritidis, Montevideo, Schwarzengrund, Hadar, Infantis, Thompson, and Mbandaka are generally pan-susceptible or display resistance to fewer antimicobials. In contrast, the majority of MPPSTs isolated globally have been reported to display MDR phenotype. There also appears to be an international spread of a few MDR serotypes including Kentucky, Schwarzengrund, Hadar, Thomson, Sentfenberg, and Enteritidis, which may pose significant challenges to the public health. The current knowledge gaps on the ecology, epidemiology, and antimicrobial resistance of MPPSTs are discussed.
Performance models of handover protocols and buffering policies in mobile wireless ATM networks (2001)

Due to the connection-oriented nature of the asynchronous transfer mode (ATM), one of the challenges in mobile wireless ATM (WATM) systems is the management of terminal handovers. When ATM connections are reestablished to follow terminals moving between areas covered by distinct base stations, seamless handover protocols are necessary to guarantee that ATM cells are delivered to terminals in the correct order, with cell loss rate and delay that satisfy the contracted quality of service (QoS). A promising approach to meet QoS requirements is based on the use of handover buffers at the (destination) base station, where transmitted cells are stored while the connection is being reestablished. Up to date, only simulation and experimental results are available to determine the performance of such protocols and buffering schemes. This paper presents the first attempt to develop an analytical modeling approach to estimate the performance of handover protocols making use of handover buffers at the base station. By incorporating several approximations, the proposed models allow designers to simultaneously take into account numerous system parameters, including handover buffer size, sustainable and peak cell rates of the ATM connection, terminal offered load, and time needed to reestablish the ATM connection. Analytical performance predictions are shown to closely match results of detailed simulation experiments, thus demonstrating the suitability of the proposed modeling framework for the selection of the most adequate solution to handle handover and provide the QoS required by end users.
Performance and Evaluation of Bipolar Fuel Cell Stacks (2000)

Abstract : Under a joint technology planning annex (TPA) agreement, fuel cell groups at the U.S. Army Research Laboratory (ARL) and the U.S. Army Communications-Electronics Command (CECOM) worked together to develop Army power sources for soldier applications. Two 50-W bipolar fuel cell stacks designed by CECOM were extensively evaluated. The performance of the stacks depended significantly on the environmental temperature. Decreasing environmental temperature granted better heat dissipation in the stacks, resulting in improved stack performance. Long-term performance of 62 W was obtained at low temperature (-5 deg C). Higher environmental temperatures caused an increase in stack surface temperature. When the stack surface temperature reached 43 deg C, the stack voltage dropped to zero within a short time. The maximum power density for long-term operation was 97.3 W/kg, or 167 W/L. The average hydrogen utilization efficiency was 95 percent. The water production efficiency was dependent on the discharge currents, varying from 40 percent (at 1.0 A) to 90 percent (at 2.5 A).
C-Acylation of Enolates by Methyl Cyanoformate: An Examination of Site- and Stereoselectivity (1990)

The scope and limitations of the acylation of preformed lithium enolates by methyl cyanoformate have been explored further. In particular, the proportion of C-acylation products in sterically hindered substrates is significantly enhanced by the use of diethyl ether as solvent, while diastereofacial selectivity in the reactions of chiral enolates is found to be similar to that observed for C-alkylations in most cases. Exceptions may occur as a consequence of the higher steric demand of the cyanoformate reagent, however.