gebhart/patrepeval huggingface dataset:
2012 Updated Consensus Guidelines for the Management of Abnormal Cervical Cancer Screening Tests and Cancer Precursors (2013)

A group of 47 experts representing 23 professional societies, national and international health organizations, and federal agencies met in Bethesda, MD, September 14-15, 2012, to revise the 2006 American Society for Colposcopy and Cervical Pathology Consensus Guidelines. The group's goal was to provide revised evidence-based consensus guidelines for managing women with abnormal cervical cancer screening tests, cervical intraepithelial neoplasia (CIN) and adenocarcinoma in situ (AIS) following adoption of cervical cancer screening guidelines incorporating longer screening intervals and co-testing. In addition to literature review, data from almost 1.4 million women in the Kaiser Permanente Northern California Medical Care Plan provided evidence on risk after abnormal tests. Where data were available, guidelines prescribed similar management for women with similar risks for CIN 3, AIS, and cancer. Most prior guidelines were reaffirmed. Examples of updates include: Human papillomavirus-negative atypical squamous cells of undetermined significance results are followed with co-testing at 3 years before return to routine screening and are not sufficient for exiting women from screening at age 65 years; women aged 21-24 years need less invasive management, especially for minor abnormalities; postcolposcopy management strategies incorporate co-testing; endocervical sampling reported as CIN 1 should be managed as CIN 1; unsatisfactory cytology should be repeated in most circumstances, even when HPV results from co-testing are known, while most cases of negative cytology with absent or insufficient endocervical cells or transformation zone component can be managed without intensive follow-up.
Auxin from the Developing Inflorescence Is Required for the Biosynthesis of Active Gibberellins in Barley Stems (2004)

Multiple gibberellins (GAs) were quantified in the stems of intact, decapitated, and decapitated auxin-treated barley (Hordeum vulgare) plants. Removal of the developing inflorescence reduced the endogenous levels of indole-3-acetic acid (IAA), GA(1), and GA(3) and increased the level of GA(29) in internodal and nodal tissues below the site of excision. Application of IAA to the excised stump restored GA levels to normal in almost all cases. The conversion of [(14)C]GA(20) to bioactive [(14)C]GA(1) and of [(14)C]GA(5) to bioactive [(14)C]GA(3) was reduced by decapitation, and IAA application was able to restore conversion rates back to the levels found in intact plants. The amount of mRNA for the principal vegetative 3-oxidase (converting GA(20) to GA(1), and GA(5) to GA(3)) was decreased in decapitated plants and restored by IAA application. The results indicate that the inflorescence of barley is a source of IAA that is transported basipetally into the internodes and nodes where bioactive GA(1) and GA(3) are biosynthesized. Thus, IAA is required for normal GA biosynthesis in stems, acting at multiple steps in the latter part of the pathway.
Lead‐rubber hysteretic bearings suitable for protecting structures during earthquakes (1982)

Abstract Lead‐rubber hysteretic bearings provide in a single unit the combined features of vertical load support, horizontal flexibility and energy absorbing capacity required for the base isolation of structures from earthquake attack. The lead‐rubber hysteretic bearing is a laminated elastomeric bearing of the type used in bridge structures, with a lead plug down its centre. Since the invention of the lead‐rubber bearing, a total of eleven bearings up to a diameter of 650mm, with lead plugs ranging from 50 to 170mm in diameter, have been tested under various conditions, including vertical loads to 3·15 MN, strokes to ρ 110 mm, rates from 1 mm/h to 100 mm/s, and temperatures of −35°C to + 45°C. In all of these tests, the lead‐rubber bearings behaved satisfactorily and the hysteresis loops could be described reasonably well by assuming that the lead behaved as an elastic‐plastic solid with a yield stress in shear of 10·55 MPa. The bearings showed little rate dependence at ∼100 mm/s, though at creep rates of ∼1 mm/h the force due to the lead dropped to 30 per cent of that at typical earthquake frequencies. The effect of many small displacements has been tested with 11000 cycles at ±3 mm. A total of 92 lead‐rubber bearings have been used in New Zealand to base isolate one building and three bridges. They have yet to be used overseas. This paper describes the tests on the lead‐rubber bearings, the results and a design procedure for selecting the size of the lead plug.
“Reduced” Coumarin Dyes with an <i>O</i>‐Phosphorylated 2,2‐Dimethyl‐4‐(hydroxymethyl)‐1,2,3,4‐tetrahydroquinoline Fragment: Synthesis, Spectra, and STED Microscopy (2016)

Large Stokes-shift coumarin dyes with an O-phosphorylated 4-(hydroxymethyl)-2,2-dimethyl-1,2,3,4-tetrahydroquinoline fragment emitting in the blue, green, and red regions of the visible spectrum were synthesized. For this purpose, N-substituted and O-protected 1,2-dihydro-7-hydroxy-2,2,4-trimethylquinoline was oxidized with SeO2 to the corresponding α,β-unsaturated aldehyde and then reduced with NaBH4 in a "one-pot" fashion to yield N-substituted and 7-O-protected 4-(hydroxymethyl)-7-hydroxy-2,2-dimethyl-1,2,3,4-tetrahydroquinoline as a common precursor to all the coumarin dyes reported here. The photophysical properties of the new dyes ("reduced coumarins") and 1,2-dihydroquinoline analogues (formal precursors) with a trisubstituted C=C bond were compared. The "reduced coumarins" were found to be more photoresistant and brighter than their 1,2-dihydroquinoline counterparts. Free carboxylate analogues, as well as their antibody conjugates (obtained from N-hydroxysuccinimidyl esters) were also prepared. All studied conjugates with secondary antibodies afforded high specificity and were suitable for fluorescence microscopy. The red-emitting coumarin dye bearing a betaine fragment at the C-3-position showed excellent performance in stimulation emission depletion (STED) microscopy.
Facile syntheses of tetraalkylchlorin and tetraalkylporphyrin complexes and comparison of the structures of the tetramethylchlorin and tetramethylporphyrin complexes of nickel(II) (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFacile syntheses of tetraalkylchlorin and tetraalkylporphyrin complexes and comparison of the structures of the tetramethylchlorin and tetramethylporphyrin complexes of nickel(II)Abraham Ulman, Judith Gallucci, Diane Fisher, and James A. IbersCite this: J. Am. Chem. Soc. 1980, 102, 22, 6852–6854Publication Date (Print):October 15, 1980Publication History Published online1 May 2002Published inissue 15 October 1980https://pubs.acs.org/doi/10.1021/ja00542a034https://doi.org/10.1021/ja00542a034research-articleACS PublicationsRequest reuse permissionsArticle Views199Altmetric-Citations37LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Complete Nucleotide Sequence of a <i>Hordeum vulgare</i> Gene Encoding (1→3, 1→4)-β-Glucanase Isoenzyme II (1991)

Barley (1-3,1l-4)-,3-glucanases are synthesized in the scu- bp2) of the gene for (1--*3,l-4)-3-glucanase isoenzyme II is tellum and aleurone tissues during germination. The secreted 'Coding Region: 334 codons with strong bias in codons downstream of the intron for C or G in the wobble position. *3'-Noncoding Region: putative polyadenylation signal at position 4097 to 4101.
Screening for Aspirin Responsiveness After Transient Ischemic Attack and Stroke (2005)

The prevalence of apparent ASA nonresponsiveness was higher with both the POC tests than with LTA. However, agreement between the tests was poor and very few patients were ASA nonresponsive by all 3 tests. Aspirin nonresponsiveness is therefore highly test-specific and large prospective studies will be required to determine the prognostic value of each of the separate tests.
Game System of Treadmill Based on Video Capture (2010)

Game system of treadmill based on video capture combines somatosensory technique which is hot now and professional exercise and body fitness together, providing a barrierless, ease experience of entertainment for people. This set of system captures running or jumping movement by a single camera, analyses the motion information to control the treadmill speed as well as the game role in the game engine. So players can see their real actions in the screen. Multiple treadmills are connected by the network platform to achieve multiplayer game. At the end of this paper, there is a result of simulation.
The national ignition facility performance status (2006)

The National Ignition Facility (NIF) laser has been designed to support high energy density science (HEDS), including the demonstration of fusion ignition through Inertial Confinement. NIF operated a single ''quad'' of 4 beams from December 2002 through October 2004 in order to gain laser operations experience, support target experiments, and demonstrate laser performance consistent with NIF's design requirement. During this two-year period, over 400 Main Laser shots were delivered at 1{omega} to calorimeters for diagnostic calibration purposes, at 3{omega} to the Target Chamber, and at 1{omega}, 2{omega}, and 3{omega} to the Precision Diagnostics System (PDS). The PDS includes its own independent single beam transport system, NIF design frequency conversion hardware and optics, and laser sampling optics that deliver light to a broad range of laser diagnostics. Highlights of NIF laser performance will be discussed including the results of high energy 2{omega} and 3{omega} experiments, the use of multiple focal spot beam conditioning techniques, the reproducibility of laser performance on multiple shots, the generation on a single beam of a 3{omega} temporally shaped ignition pulse at full energy and power, and recent results on full bundle (8 beamline) performance. NIF's first quad laser performance meets or exceeds NIF's design requirements.
Regioselective <font>α</font>-Bromination of Aralkyl Ketones Using N-Bromosuccinimide in the Presence of Montmorillonite K-10 Clay: A Simple and Efficient Method (2013)

Abstract A simple and more convenient method has been developed for regioselective α-bromination of various aralkyl ketones with N-bromosuccinimide (NBS) in the presence of Montmorillonite K-10 catalyst in methanol at 60–65 °C. The present procedure offers advantages of short reaction time, simple workup, good yields of products and reusability of the catalyst for four times without loss of activity. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications® to view the free supplemental file.
Lysobisphosphatidic Acid Controls Endosomal Cholesterol Levels (2008)

Most cell types acquire cholesterol by endocytosis of circulating low density lipoprotein, but little is known about the mechanisms of intra-endosomal cholesterol transport and about the primary cause of its aberrant accumulation in the cholesterol storage disorder Niemann-Pick type C (NPC). Here we report that lysobisphosphatidic acid (LBPA), an unconventional phospholipid that is only detected in late endosomes, regulates endosomal cholesterol levels under the control of Alix/AlP1, which is an LBPA-interacting protein involved in sorting into multivesicular endosomes. We find that Alix down-expression decreases both LBPA levels and the lumenal vesicle content of late endosomes. Cellular cholesterol levels are also decreased, presumably because the storage capacity of endosomes is affected and thus cholesterol clearance accelerated. Both lumenal membranes and cholesterol can be restored in Alix knockdown cells by exogenously added LBPA. Conversely, we also find that LBPA becomes limiting upon pathological cholesterol accumulation in NPC cells, because the addition of exogenous LBPA, but not of LBPA isoforms or analogues, partially reverts the NPC phenotype. We conclude that LBPA controls the cholesterol capacity of endosomes.
The Multiple Facets of Hematopoietic Stem Cells (2004)

Hematopoietic stem cells (HSCs) have long been defined as a cell with the capacity to repopulate the hematopoietic system of a lethally irradiated host. In clinical medicine, this property has been employed to reconstitute an individual's diseased hematopoietic system following ablation with a healthy, normal-functioning hematopoietic system by performing autologous and allogeneic stem cell transplantations. However, despite the widespread utilization of these pragmatic procedures for multiple human bone marrow diseases, much about the basic biology of the HSC and related primitive cells, such as the ontogenic origin of the HSC, the identification of the putative hemangioblast, and the potential of the HSC to contribute to alternative tissues, remains elusive. Basic scientists continue to investigate actively the origin of HSCs during mammalian ontogeny, the stimuli that induce HSCs to divide and differentiate normally, the relationship of HSCs to hemangioblasts, and the potential capacity of HSCs to transdifferentiate to other tissues such as endoderm-derived liver cells and ectoderm-derived neurons. This article will summarize the historical salient studies that have characterized the HSC and will review the active research currently being conducted to understand and define further the biologic properties and potential faculties of HSCs. The application of these studies to improved therapies for human disease, from leukemia to myocardial infarction, will be discussed.
Mastering startup costs in assembler-based compiled instruction-set simulation (2003)

The increasing size and complexity of embedded software requires extremely fast instruction-set simulation. Compiled instruction-set simulation can provide high simulation speed, but the cost of generating and compiling the simulator can be a problem. We claim that efficient compiled instruction-set simulation with small startup costs is possible, using our assembler-level approach. We present ABSCISS, a retargetable and flexible system that generates optimized compiled simulators from assembler programs. Experimental results show the produced simulators to be significantly faster than interpretive simulators, and also show that our assembler-based approach allows to master the simulator generation and compilation times.
In Vitro Inhibition of HIV-1 Infectivity by Human Salivas (1990)

Inhibitory factors to human immunodeficiency virus type 1 (HIV-1) in saliva may be responsible for the infrequent isolation of virus from saliva and also may account for the marked infrequency of salivary and/or oral transmission of HIV-1. Incubation of HIV-1 with human saliva followed by addition of the mixture to susceptible cells leads to partial or complete suppression of viral replication in vitro. We investigated the inhibitory effects of whole saliva and specific glandular salivas on HIV-1 infectivity as measured by viral-induced cytopathic effects in susceptible cells. Whole saliva contained marked inhibitory activity to HIV-1, strain HTLV-IIIB, and to virus infected cells. Submandibular saliva contained inhibitory activity, but of lesser quantity. Parotid saliva demonstrated no HIV-inhibitory activity. Whole saliva also appeared to contain filterable components that were inhibitory to lymphocyte growth. Passage through a .45 micron pore-size filter eliminated the viral inhibitory activity of submandibular saliva and some of the activity in whole saliva. All salivas except parotid incubated with HIV-1 followed by filtration were inhibitory suggesting that complexing of virus with high molecular weight, submandibular mucins may play a role in viral inhibition.
Vacant parking space detector for outdoor parking lot by using surveillance camera and FCM classifier (2009)

The most prevailing approach now for parking lot vacancy detecting system is to use sensor-based techniques. The main impediments to the camera-based system in applying to parking lots on rooftop and outside building are the glaring sun light and dark shadows in the daytime, and low-light intensity and back-lighting in the nighttime. To date, no camera-based detecting systems for outdoor parking lots have been in practical use. A few engineering firms provide the camera-based system, which is only for underground and indoor parking lots. This paper reports on the new camera based system called ParkLotD for detecting vacancy/occupancy in parking lots. ParkLotD uses a classifier based on fuzzy c-means (FCM) clustering and hyper-parameter tuning by particle swarm optimization (PSO). The test result of the detection error rate for the indoor multi-story parking lot has improved by an order of magnitude compared to the current system based on the edge detection approach. ParkLotD demonstrates high detection performance and enables the camera-based system to achieve the practical use in outdoor parking lots.
Biomechanics of walking, running, and sprinting (1980)

A biomechanical study of 13 runners which consisted of 2 male sprinters, 5 experienced joggers, and 6 elite long-distance runners were studied. We obtained hip, knee, and ankle joints motions in the sagittal plane and electromyographic data from specific muscle groups. As the speed of gait increased, the length of stance phase progressively decreased from 62% for walking to 31% for running and to 22% for sprinting. The sagittal plane motion increased as the speed of gait increased. Generally speaking, the body lowers its center of gravity with the increased speed by increasing flexion of the hips and knees and magnifying dorsiflexion at the ankle joint. Electromyographic activity about the knee demonstrated increased activity in the quadricep muscle group and hamstring group with increased speed. Muscle function about the ankle joint demonstrated that the posterior calf musculature which normally functions during the midstance phase in walking became a late swing phase muscle and was active through the first 80% of stance phase, as compared to 15% in walking. Beside the changes in the electromyographic activity of the muscles, the anterior compartment muscles of the calf undergo a concentric contracture at the time of initial floor contact during running and sprinting but undergo an eccentric contraction during walking.
Tissue reaction of bioabsorbable ultra high strength poly (L-lactide) rod. A long-term study in rabbits. (1995)

Bioabsorbable ultra high strength poly (L-lactide) rods, which were developed for internal fixation of fractures, were fabricated using a drawing technique. These rods were implanted in the subcutaneous tissue and in the medullary cavity of rabbits to investigate tissue reactions to poly (L-lactide) and to study their degradation process. After 18 months, histiocytes were found, and their phagocytic activity continued for as long as 42 months, with maximum activity observed between 24 and 36 months after implantation. At 62 months after intramedullary implantation, the materials had been absorbed almost completely and were replaced by bone marrow cells, with only a small amount of residual tissue reaction. At 69 months after subcutaneous implantation, the materials had been absorbed completely without any scar formation. During degradation, no foreign body giant cells were found and osteolytic expansion caused by liquid degradable materials was not seen.
Synthesis of Blue Luminescent Si Nanoparticles Using Atmospheric-Pressure Microdischarges (2005)

Silicon nanoparticles are synthesized from a mixture of argon/silane in a continuous flow atmospheric-pressure microdischarge reactor. Particles nucleate and grow to a few nanometers (1-3 nm) in diameter before their growth is abruptly terminated in the short residence time microreactor. Narrow size distributions are obtained as inferred from size classification and imaging. As-grown Si nanoparticles collected in solution exhibit room-temperature photoluminescence that peaks at 420 nm with a quantum efficiency of 30%; the emission is stable for months in ambient air.
Human apolipoprotein E promotes hepatitis B virus infection and production (2019)

Hepatitis B virus (HBV) is a common cause of liver diseases, including chronic hepatitis, steatosis, fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). HBV chronically infects about 240 million people worldwide, posing a major global health problem. The current standard antiviral therapy effectively inhibits HBV replication but does not eliminate the virus unlike direct-acting antivirals (DAA) for curing hepatitis C. Our previous studies have demonstrated that human apolipoprotein E (apoE) plays important roles in hepatitis C virus infection and morphogenesis. In the present study, we have found that apoE is also associated with HBV and is required for efficient HBV infection. An apoE-specific monoclonal antibody was able to capture HBV similar to anti-HBs. More importantly, apoE monoclonal antibody could effectively block HBV infection, resulting in a greater than 90% reduction of HBV infectivity. Likewise, silencing of apoE expression or knockout of apoE gene by CRISPR/Cas9 resulted in a greater than 90% reduction of HBV infection and more than 80% decrease of HBV production, which could be fully restored by ectopic apoE expression. However, apoE silencing or knockout did not significantly affect HBV DNA replication or the production of nonenveloped (naked) nucleocapsids. These findings demonstrate that human apoE promotes HBV infection and production. We speculate that apoE may also play a role in persistent HBV infection by evading host immune response similar to its role in the HCV life cycle and pathogenesis. Inhibitors interfering with apoE biogenesis, secretion, and/or binding to receptors may serve as antivirals for elimination of chronic HBV infection.
A Flexible Capacitive Tactile Sensor Array With CMOS Readout Circuits for Pulse Diagnosis (2014)

Pulse diagnosis is one of the major methods used in traditional Chinese medicine to evaluate a patient's health conditions. Determination of pulse patterns is, however, a matter that depends on technical skill and subjective experience of a doctor. Development of a pulse diagnosis apparatus can lead to modernization and advancement of the field by providing more objective and accurate evaluations. This paper aims at demonstrating real-time pulse measurement using the developed flexible capacitive tactile sensors. A $5\times 5$ sensor array of 0.75 cm $\times $ 1 cm in size was implemented using flexible printed circuit boards and integrated with CMOS switched-capacitor readout circuits. The measured average output sensitivity was 1.57 mV/mmHg and minimum detectable pressure and capacitance were at the sub-mmHg and sub-fF levels, respectively. The cross sensitivity was measured to be 7.8%. Real-time pulse measurement has been successfully demonstrated using the developed flexible sensor array.