gebhart/patrepeval huggingface dataset:
c-kit D816V Provides a Strong Signal for Myelomastocytic Differentiation and Cluster Formation in Murine Ba/F3 Cells. (2004)

Abstract The pathologic hallmark of systemic mastocytosis (SM) is differentiation and cluster formation of mast cells (MC) in hematopoietic tissues. The somatic c-kit mutation D816V is detectable in a majority of all SM patients independent of the proliferation-status of MC or subtype (indolent or aggressive) of disease. To investigate the role of c-kit D816V in the pathogenesis of SM, we established a Ba/F3 cell line with doxycycline-inducible expression of c-kit D816V. We found that c-kit D816V provides a strong signal for mast cell differentiation and cluster formation in Ba/F3 hematopoietic progenitor cells without enhancing their growth thereby resembling the clinical presentation of indolent SM (ISM). As assessed by gene chip analysis, induction of c-kit D816V resulted in expression of various differentiation antigens including mouse mast cell protease 5, mi transcription factor, histidine decarboxylase (HDC), secretory granule proteoglycan, IL-4 receptor, ICAM-1, and CD63 consistent with an early phase of mastopoiesis. By contrast, c-kit D816V did neither induce expression of granulo-monocytic antigens such as myeloperoxidase, IL-3 receptor, or GM-CSF receptor, nor expression of ‘late stage’ mast cell antigens such as FcεRI. The c-kit D816V-induced synthesis of histamine in Ba/F3 cells was confirmed by RIA. To examine the role of c-kit D816V in the pathogenesis of mastocytosis, we extended our analysis to bone marrow biopsy sections obtained from patients with ISM. In these experiments, the D816V-mutated form of c-kit was detected more frequently in micro-dissected tryptase-positive MC obtained from dense compact infiltrates (44.2%) than in diffusely spread MC in these patients (22.6%) (p&lt;0.05). In summary, our data establish a role for c-kit D816V in differentiation and cluster formation of neoplastic (mast) cells. Additional genetic hits, apart from c-kit D816V, may be responsible for aggressive growth of MC in advanced MC neoplasms.
A New Impedance-Matched Wide-Band Balun and Magic Tee (1976)

A new wide-band microwave balun particularly attractive for microstrip circuitry is described in which the normally balanced line is in the form of a pair of equal-amplitude and antiphase unbalanced lines. This novel method of input-output coupling allows a coplanar arrangement of input and output microstrip lines. Often the balanced and unbalanced line impedances in a balun are unequal, necessitating an impedance-matching network. A first-order reflection coefficient theory that mutually considers the impedance effects of the balun cavity, a compensating stub, and a quarter-wave transformer is used to design wide-band impedance-matched baluns. Curves of VSWR versus bandwidth are presented for several balanced-to-unbalanced line-impedance ratios. Experimental results are given for an octave-band impedance-matched balun with a balanced-to-unbalanced impedance ratio of 2:1. The new wide-band balun is adaptable to a microstrip magic tee. A proposed magic tee that relies on circuit symmetry for operation has multioctave bandwidth potential.
Event statistics and criticality-aware bitrate allocation to minimize energy consumption of memory-constrained wireless surveillance system (2010)

An event criticality-aware wireless surveillance system tries to minimize the energy consumption by adjusting the image distortion (or quality) requirement according to event criticality. In this paper, we present a novel video encoding method which scales bitrate so as to minimize the energy consumption of the wireless surveillance system while satisfying the given memory constraint. Given event statistics, memory size, and distortion requirement, the presented method gives an energy-optimal bitrate based on an analytic formulation of energy-rate-distortion (E-R-D) relationship for the target system consisting of H.264 video encoder, event detector, transceiver and memory. Experimental results show that the proposed method offers up to 59.6% (29.1% on average) energy savings compared to an existing bitrate allocation method which does not consider event statistics.
Mitochondria in cancer: at the crossroads of life and death (2011)

Mitochondrial processes play an important role in tumor initiation and progression. In this review, we focus on three critical processes by which mitochondrial function may contribute to cancer: through alterations in glucose metabolism, the production of reactive oxygen species (ROS) and compromise of intrinsic apoptotic function. Alterations in cancer glucose metabolism include the Warburg effect, leading to a shift in metabolism away from aerobic respiration toward glycolysis, even when sufficient oxygen is present to support respiration. Such alterations in cellular metabolism may favor tumor cell growth by increasing the availability of biosynthetic intermediates needed for cellular growth and proliferation. Mutations in specific metabolic enzymes, namely succinate dehydrogenase, fumarate hydratase and the isocitrate dehydrogenases, have been linked to human cancer. Mitochondrial ROS may contribute to cancer via DNA damage and the activation of aberrant signaling pathways. ROS-dependent stabilization of the transcription factor hypoxia-inducible factor (HIF) may be a particularly important event for tumorigenesis. Compromised function of intrinsic apoptosis removes an important cellular safeguard against cancer and has been implicated in tumorigenesis, tumor metastasis, and chemoresistance. Each of the major mitochondrial processes is linked. In this review, we outline the connections between them and address ways these mitochondrial pathways may be targeted for cancer therapy.
Résonnances photoniques dans les réseaux métalliques : théorie et application à la photodétection ultrarapide (2002)

Les nanostructures metalliques presentent, grâce aux resonances de surface qu'elles supportent, la possibilite de confiner et de controler la lumiere sur des dimensions tres inferieures a la longueur d'onde. Durant cette these, nous avons etudie le cas des reseaux de fentes metalliques. Nous avons mis en oeuvre un calcul original des courbes de dispersion complexes des reseaux metalliques, base sur une methode modale et un formalisme de matrice S. Le calcul des structures de bandes photoniques complexes et de la repartition spatiale du champ electromagnetique a permis de decrire precisement les resonances de surface horizontales et verticales, leurs conditions d'excitation ainsi que leurs durees de vie radiatives et non radiatives. Leurs proprietes de confinement et de transmission de la lumiere dans des fentes tres fines devant la longueur d'onde offrent de nouvelles possibilites en optoelectronique. Nous proposons en particulier deux structures de type metal-semiconducteur-metal pour la photodetection ultrarapide, dans lesquelles le confinement de l'absorption permet de repousser le compromis habituel entre rendement et vitesse. La premiere structure est un reseau metal/semiconducteur dans lequel la lumiere est absorbee entre les electrodes. La seconde structure permet une absorption efficace dans une fine couche sous le reseau metallique. Ces deux photodetecteurs, dont la distance inter-electrode est d'environ 100 nm, ont ete fabriques sur substrat de GaAs. Le bon accord des mesures de reflectivite et de photocourant avec la theorie a permis de valider cette approche, qui pourra notamment etre appliquee aux longueurs d'onde des telecommunications. Les dimensions mises en jeu rendent possibles des frequences de coupure de plusieurs centaines de GHz, avec un rendement theorique de 75 % independamment de la polarisation de la lumiere. Ces resultats ouvrent la voie a une nouvelle generation de photodetecteurs ultrarapides.
Virtual Edge-Based Smart Community Network Management (2016)

Providing multitenant, multiaccess, and multiservice solutions in communities is a key enabler to sustain innovations and economic development in society. This article investigates a solution for rearchitecting a telecommunications company's (telco's) central office to offer services in a smart community, enabled by virtual network function elements running on a smart edge. At the same time, these elements manage a multiaccess underlying infrastructure and deploy telco services with minimal resource consumption. This solution has successfully been implemented in a living lab model the authors built within a Canadian university, providing various Internet of Things (IoT) services such as smart grid monitoring and public safety. The virtual smart edge flexibly routes traffic, aggregates, and splits flows across a heterogeneous network to achieve network operational efficiency, as well as optimizes computing resource allocation for last-mile IoT services hosted close to the end user. Instead of reducing resource consumption in a single home as in the traditional approach, this solution minimizes a community's global consumption.
Advances in introgression technologies for precision breeding within the <i>Lolium ‐ Festuca</i> complex (2003)

Summary The anticipated complexity of multifunctional grasslands with environment‐friendly and sustainable management practices demands better understanding of traits, their interactions, and their genetic control. Intergeneric hybrids between closely related Lolium and Festuca species are being used to broaden the gene pool and provide the plant breeder with options to combine complementary traits aimed at high quality but more robust grass varieties for the future. New techniques in introgression mapping provide opportunities for precision breeding whereby desirable gene combinations transferred from one species into another are selected preferentially, with the exclusion of deleterious alien genes. The close homology between genomes of Lolium and Festuca species allows high levels of chromosome pairing and recombination. Using genomic in situ hybridisation (GISH) on Lolium/Festuca hybrids and their derivatives, recombination between Lolium and Festuca chromosomes is observed at any point along the chromosome. The system provides unlimited access to any combination of Lolium and Festuca DNA sequence. Moreover, genes transferred between homoeologous chromosome sites are expected to function normally at their new locations. Alien chromosome segments may be reduced in size by further recombination events thereby reducing linkage drag. Molecular markers such as AFLPs, SSRs, SNPs, or RFLPs are being targeted to genes of interest to allow their selection through different generations in plant breeding programmes. Relatively simple PCR‐based marker systems are used for specific traits as breeders' toolkits in plant breeding programmes.
Chronic inflammation induces telomere dysfunction and accelerates ageing in mice (2014)

Chronic inflammation is associated with normal and pathological ageing. Here we show that chronic, progressive low-grade inflammation induced by knockout of the nfkb1 subunit of the transcription factor NF-κB induces premature ageing in mice. We also show that these mice have reduced regeneration in liver and gut. nfkb1(-/-) fibroblasts exhibit aggravated cell senescence because of an enhanced autocrine and paracrine feedback through NF-κB, COX-2 and ROS, which stabilizes DNA damage. Preferential accumulation of telomere-dysfunctional senescent cells in nfkb1(-/-) tissues is blocked by anti-inflammatory or antioxidant treatment of mice, and this rescues tissue regenerative potential. Frequencies of senescent cells in liver and intestinal crypts quantitatively predict mean and maximum lifespan in both short- and long-lived mice cohorts. These data indicate that systemic chronic inflammation can accelerate ageing via ROS-mediated exacerbation of telomere dysfunction and cell senescence in the absence of any other genetic or environmental factor.
AN INVESTIGATION ON THE PRESENCE OF NiAl2O4 IN A STABLE Ni ON ALUMINA CATALYST FOR DRY REFORMING (2005)

Comprehensive temperature-programmed reduction, X-ray diffraction and diffuse reflectance spectroscopy studies were conducted on a stable nickel (10.5%) catalyst obtained through conventional impregnation of a sol-gel made support of g-Al2O3, to elucidate the interactions between nickel oxide and support. The results pointed to the presence of a NiAl2O4 spinel layer on the surface produced by the strong interaction between NiO and the support. These interactions might be responsible for its high activity, stability and resistance to coking
Direct Localization of Emitters Based on Sparse Bayesian Learning (2019)

In this paper, a novel perspective for the problem of direct localization of emitters is presented based on sparse Bayesian learning (SBL). The localization problem is addressed in three scenarios, where we derive the angle-of-arrival (AOA) based models for two kinds of narrowband conditions and the model jointly taking use of time-difference-of-arrival (TDOA) and AOA information. Unlike the existing ℓ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sub> -penalization based direct localization methods, we expand the localization models to the sparsity-based framework with the scheme of SBL, which makes the partly unknown dictionary based problems solvable. On the basis of the bound-optimization SBL algorithm, modifications are provided to make its solving procedures adapt to the localization models. For one thing, the learning rule of channel attenuation factors (i.e., the unknown part of the dictionaries) is added in the solving procedures. For another, we expand the original single measurement vector (SMV) based model to the multiple measurement vector (MMV) scenario. Furthermore, we modify the original procedures by updating the parameters with an alternating minimization strategy, which guarantees the convergence of the algorithms. Simulation results show the features of three SBL-based models and the performance superiority of the proposed methods.
Preference programming: Advanced problem solving for configuration (2003)

Configuration problems often involve large product catalogs, and the given user requests can be met by many different kinds of parts from this catalog. Hence, configuration problems are often weakly constrained and have many solutions. However, many of those solutions may be discarded by the user as long as more interesting solutions are possible. The user often prefers certain choices to others (e.g., a red color for a car to a blue color) or prefers solutions that minimize or maximize certain criteria such as price and quality. In order to provide satisfactory solutions, a configurator needs to address user preferences and user wishes. Another important problem is to provide high-level features to control different reasoning tasks such as solution search, explanation, consistency checking, and reconfiguration. We address those problems by introducing a preference programming system that provides a new paradigm for expressing user preferences and user wishes and provides search strategies in a declarative and unified way, such that they can be embedded in a constraint and rule language. The preference programming approach is completely open and dynamic. In fact, preferences can be assembled from different sources such as business rules, databases, annotations of the object model, or user input. An advanced topic is to elicit preferences from user interactions, especially from explanations of why a user rejects proposed choices. Our preference programming system has successfully been used in different configuration domains such as loan configuration, service configuration, and other problems.
Tough Photoluminescent Hydrogels Doped with Lanthanide (2015)

Photoluminescent hydrogels have emerged as novel soft materials with potential applications in many fields. Although many photoluminescent hydrogels have been fabricated, their scope of usage has been severely limited by their poor mechanical performance. Here, a facile strategy is reported for preparing lanthanide (Ln)-alginate/polyacrylamide (PAAm) hydrogels with both high toughness and photoluminescence, which has been achieved by doping Ln(3+) ions (Ln = Eu, Tb, Eu/Tb) into alginate/PAAm hydrogel networks, where Ln(3+) ions serve as both photoluminescent emitters and physical cross-linkers. The resulting hydrogels exhibit versatile advantages including excellent mechanical properties (∼ MPa strength, ≈ 20 tensile strains, ≈ 10(4) kJ m(-3) energy dissipation), good photoluminescent performance, tunable emission color, excellent processability, and cytocompatibility. The developed tough photoluminescent hydrogels hold great promises for expanding the usage scope of hydrogels.
Always Already (1998)

Review| April 01 1998 Always Already: Affinities Between Art ana Film J. Ronald Green J. Ronald Green J. Ronald Green teaches film studies in the Department of History of Art at the Ohio State University. His article, “Micheaux v. Griffith,” appeared in the Fall 1997 issue of Griffithiana, Pordenone, Italy. Search for other works by this author on: This Site PubMed Google Scholar Afterimage (1998) 25 (5): 8–11. https://doi.org/10.1525/aft.1998.25.5.8 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation J. Ronald Green; Always Already: Affinities Between Art ana Film. Afterimage 1 April 1998; 25 (5): 8–11. doi: https://doi.org/10.1525/aft.1998.25.5.8 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAfterimage Search This content is only available via PDF. © 1998 by The Regents of the University of California1998 Article PDF first page preview Close Modal You do not currently have access to this content.
k -domain linearization of wavelength-swept laser for optical coherence tomography (2011)

We propose a new method for <i>k</i>-domain linearization using fiber Bragg gratings (FBGs) in a wavelength-swept source for optical coherence tomography (OCT). A wavelength-swept source with a scanning fiber Fabry-Perot tunable filter is constructed using a conventional ring laser cavity. Five FBGs are used to recalibrate the nonlinear response from the wavelength-swept source. We achieved good quality sample imaging using the <i>k</i>-domain linearization algorithm based on FBGs. The sensitivity at 2 mm is improved by more than 10 dB after <i>k</i>-domain linearization.
Design Choices in Needle Steering—A Review (2014)

Alignment errors can arise during needle tip placement in deep-seated tissue structures. This can lead to undesired diagnostic and therapeutic outcomes. Path correction by means of needle steering has been investigated in scientific studies for the past decades. Several approaches exist, each of them with their own strengths and weaknesses. This paper describes the various needle-steering techniques, and discusses their applicability in terms of mechanical design choices in order to assess and guide on-going work in this research area. Included steering techniques apply needle base manipulations, bevel tips, precurved stylets, active cannulas, programmable bevels, and tendon actuated tips. Techniques are classified as either passive or active, based on how steering is achieved. Mechanical properties of developed needles differ largely. Flexural rigidity, for instance, was found to vary with a factor 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sup> . Mechanical interactions, such as torsion and buckling, are described individually. Different research objectives have led to different steerable needle designs. Design criteria are typically based on these objectives, and not necessarily on clinical needs. However, the effectiveness of steering techniques depends heavily on this design, the navigation medium, and the intended task. In the proposed classification scheme, this dependence is quantified by the flexural rigidity.
Artificial MicroRNA-Mediated Virus Resistance in Plants (2007)

RNA silencing in plants is a natural defense system against foreign genetic elements including viruses. This natural antiviral mechanism has been adopted to develop virus-resistant plants through expression of virus-derived double-stranded RNAs or hairpin RNAs, which in turn are processed into small interfering RNAs (siRNAs) by the host's RNA silencing machinery. While these virus-specific siRNAs were shown to be a hallmark of the acquired virus resistance, the functionality of another set of the RNA silencing-related small RNAs, microRNAs (miRNAs), in engineering plant virus resistance has not been extensively explored. Here we show that expression of an artificial miRNA, targeting sequences encoding the silencing suppressor 2b of Cucumber mosaic virus (CMV), can efficiently inhibit 2b gene expression and protein suppressor function in transient expression assays and confer on transgenic tobacco plants effective resistance to CMV infection. Moreover, the resistance level conferred by the transgenic miRNA is well correlated to the miRNA expression level. Comparison of the anti-CMV effect of the artificial miRNA to that of a short hairpin RNA-derived small RNA targeting the same site revealed that the miRNA approach is superior to the approach using short hairpin RNA both in transient assays and in transgenic plants. Together, our data demonstrate that expression of virus-specific artificial miRNAs is an effective and predictable new approach to engineering resistance to CMV and, possibly, to other plant viruses as well.
CHARACTERISTICS OF POLYAMIDEIMIDE FILM (1971)

Developing a film of polyamideimide resin, the authors studied the film's general characteristics and electrical properties, for the latter, using model coils. Even when subjected to heating at a temperature of 240 degrees C for 20 days continuously, the polyamideimide film showed practically no drop either in tensile strength or dielectric strength. Over a wide temperature range, also, it indicated stable dielectric characteristics. Tests with a model coil proved that insulation layers of the polyamideimide film can be made far thinner than conventional mica insulation layers. Moreover, having such additional advantages as higher resistances to irradiation and chemicals, the new film can be used profitably in synchronous machines, induction motors, DC machines, and transformers.