gebhart/patrepeval huggingface dataset:
Profiles of Immunoglobulin M (IgM) and IgG Antibodies against Defined Carbohydrate Epitopes in Sera of<i>Schistosoma</i>-Infected Individuals Determined by Surface Plasmon Resonance (2001)

We report here that sera of children and adults infected with Schistosoma mansoni, S. haematobium, or S. japonicum contain antibodies against GalNAcbeta1-4(Fucalpha1-2Fucalpha1-3)GlcNAc (LDN-DF) and to a lesser extent to Galbeta1-4(Fucalpha1-3)GlcNAc (Lewis(x)) and GalNAcbeta1-4GlcNAc (LDN). Surface plasmon resonance (SPR) spectroscopy was used to monitor the presence of serum antibodies to neoglycoconjugates containing these carbohydrate epitopes and to define the immunoglobulin M (IgM) and IgG subclass distribution of the antibodies. The serum levels of antibodies to LDN-DF are high related to LDN and Lewis(x) for all examined groups of Schistosoma-infected individuals. A higher antibody response to the LDN-DF epitope was found in sera of infected children than in sera of infected adults regardless of the schistosome species. With respect to the subclasses, we found surprisingly that individuals infected with S. japonicum have predominantly IgG antibodies, while individuals infected with S. mansoni mainly show an IgM response; high levels of both isotypes were measured in sera of individuals infected with S. haematobium. These data provide new insights in the human humoral immune response to schistosome-derived glycans.
Composite Cure Process Modeling and Simulations using COMPRO® and Validation of Residual Strains using Fiber Optics Sensors (2016)

Composite cure process induced residual strains and warping deformations in composite components present significant challenges in the manufacturing of advanced composite structure. As a part of the Manufacturing Process and Simulation initiative of the NASA Advanced Composite Project (ACP), research is being conducted on the composite cure process by developing an understanding of the fundamental mechanisms by which the process induced factors influence the residual responses. In this regard, analytical studies have been conducted on the cure process modeling of composite structural parts with varied physical, thermal, and resin flow process characteristics. The cure process simulation results were analyzed to interpret the cure response predictions based on the underlying physics incorporated into the modeling tool. In the cure-kinetic analysis, the model predictions on the degree of cure, resin viscosity and modulus were interpreted with reference to the temperature distribution in the composite panel part and tool setup during autoclave or hot-press curing cycles. In the fiber-bed compaction simulation, the pore pressure and resin flow velocity in the porous media models, and the compaction strain responses under applied pressure were studied to interpret the fiber volume fraction distribution predictions. In the structural simulation, the effect of temperature on the resin and ply modulus, and thermal coefficient changes during curing on predicted mechanical strains and chemical cure shrinkage strains were studied to understand the residual strains and stress response predictions. In addition to computational analysis, experimental studies were conducted to measure strains during the curing of laminated panels by means of optical fiber Bragg grating sensors (FBGs) embedded in the resin impregnated panels. The residual strain measurements from laboratory tests were then compared with the analytical model predictions. The paper describes the cure process procedures and residual strain predications, and discusses pertinent experimental results from the validation studies.
Capitalisation and debt reduction : binding private rulings (2016)

The current stressed economic times often have a negative effect on the performance and sustainability of many businesses across a range of industries. As a result, many companies are forced to restructure their debt, which often involves debt relief in various forms. From years of assessment commencing on or after 1 January 2013, the tax consequences flowing from debt reductions were amended. The Explanatory Memorandum on the Taxation Laws Amendment Bill 2012 provided the rationale for the amendments as follows. Debtors in distress seeking relief are a recurring economic concern. With the recent global financial crisis, an unusually large number of companies are experiencing financial distress. Relief for these companies is essential if local economic recovery is to occur.
Characterisation and Modelling of MEMS Ultrasonic Transducers (2006)

Silicon ultrasonic transducer micro arrays based on micro-electro-mechanicalsystem (MEMS) technologies are gaining popularity for applications in sonar sensing and excitation [1]. A current challenge for many researchers is modelling the dynamic performance of these and other micro-mechanical devices to ascertain their performance and explain experimental observations reported [2]. In this work, the performance simulation of a MEMS ultrasonic transducer array made from silicon nitride has been successfully carried out using CoventorWare package. The dynamic response of the entire transducer array was characterised, and the results were compared with theoretical predictions. Individual elements were found to vibrate with Bessel-like displacement patterns, and they were resonant at approximately 3 MHz, depending on thickness and lateral dimensions [3]. The frequency shows a linear dependence around the common thickness of 2 µm. Peak displacement levels were examined as a function of frequency, DC bias voltage, and AC drive voltage. Accounting for fabrication variations, and uniformity variations across the wafer, the full array showed minimal variations in peak out-of-plane displacement levels across the device, and isolated elements that were over-responsive and under-responsive. Presently, the effect of observed variations across the array on the performance of the transducers and their radiated fields are being examined.
A critique: relationship of the time derivative of pressure to blood flow (1965)

The relationship of the time derivative of pressure to instantaneous aortic blood flow was studied in six dogs. Pressure was measured with calibrated high-fidelity manometry and flow with an electromagnetic flowmeter. The true time constants of the equation of fluid motion (relating blood flow to the pressure gradient) were calculated and compared to the magnitude of time constants necessary to produce flow contours computed from the pressure time derivative that empirically “matched” flows measured by the electromagnetic flowmeter. It was found that time constants which produced acceptable “matching” were approximately 20 times too large. This observation demonstrated that 1) the time derivative of pressure is not proportional to the pressure gradient and 2) the similarity of measured and computed flows, using the pressure derivative, depends not on the laws of fluid motion but rather on the accidental similarity of the final form of the equation of fluid motion (with pressure derivative substituted for pressure gradient) to an empirical equation describing the hydraulic input impedance to the aorta. pressure gradient technique; blood velocity; analog computer Submitted on September 30, 1964
A straightforward approach to the synthesis of the tricyclic core of taxol (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA straightforward approach to the synthesis of the tricyclic core of taxolZhaoyin Wang, Scott E. Warder, Helene Perrier, Erich L. Grimm, Michael A. Bernstein, and Richard G. BallCite this: J. Org. Chem. 1993, 58, 11, 2931–2932Publication Date (Print):May 1, 1993Publication History Published online1 May 2002Published inissue 1 May 1993https://pubs.acs.org/doi/10.1021/jo00063a003https://doi.org/10.1021/jo00063a003research-articleACS PublicationsRequest reuse permissionsArticle Views336Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Design and Optimization of a 3-Coil Inductive Link for Efficient Wireless Power Transmission (2011)

Inductive power transmission is widely used to energize implantable microelectronic devices (IMDs), recharge batteries, and energy harvesters. Power transfer efficiency (PTE) and power delivered to the load (PDL) are two key parameters in wireless links, which affect the energy source specifications, heat dissipation, power transmission range, and interference with other devices. To improve the PTE, a 4-coil inductive link has been recently proposed. Through a comprehensive circuit based analysis that can guide a design and optimization scheme, we have shown that despite achieving high PTE at larger coil separations, the 4-coil inductive links fail to achieve a high PDL. Instead, we have proposed a 3-coil inductive power transfer link with comparable PTE over its 4-coil counterpart at large coupling distances, which can also achieve high PDL. We have also devised an iterative design methodology that provides the optimal coil geometries in a 3-coil inductive power transfer link. Design examples of 2-, 3-, and 4-coil inductive links have been presented, and optimized for 13.56 MHz carrier frequency and 12 cm coupling distance, showing PTEs of 15%, 37%, and 35%, respectively. At this distance, the PDL of the proposed 3-coil inductive link is 1.5 and 59 times higher than its equivalent 2- and 4-coil links, respectively. For short coupling distances, however, 2-coil links remain the optimal choice when a high PDL is required, while 4-coil links are preferred when the driver has large output resistance or small power is needed. These results have been verified through simulations and measurements.
[Primary cutaneous anaplastic large cell lymphoma: clinical presentation, therapy and prognosis study of 10 cases]. (2010)

PCALCL is found more commonly in males. Visceral and lymph node involvement are rare. The patients with single lesion have a longer disease-free survival than those with multiple lesions after surgical excision in combination with chemotherapy or radiotherapy. Multiple lesions can not be cured.
<i>In Vitro</i> Isothermal Nucleic Acid Amplification Assisted Surface-Enhanced Raman Spectroscopic for Ultrasensitive Detection of <i>Vibrio parahaemolyticus</i> (2017)

Detection of pathogenic microorganisms is of great importance for public health and food safety. Traditional protocols can hardly meet the continuously increasing demand in sensitivity and specificity of pathogen detections. In this study, we adopted Vibrio parahaemolyticus (V. parahaemolyticus, Vp) as the model analyte, and developed an antibody-Vp-aptamer heterosandwich-based surface-enhanced Raman scattering (SERS) method in conjunction with in vitro isothermal amplification for sensitive detection of V. parahaemolyticus. The rolling circular amplification (RCA) products provided enormous sites for assembling the Au@Ag nanoparticles and forming excess "hot-spot" sites for Raman measurement. By using this enhanced Raman signal strategy in the detection, a limit of detection (LOD) as low as 1 cfu/mL was successfully achieved for ultrasensitive detection of V. parahaemolyticus. In addition, we have applied this method to artificially contaminated food samples. The detection data indicated that this method is able to determine the concentrations of V. parahaemolyticus in the spiked food samples with satisfactory sensitivity and specificity and, thus, this developed ultrasensitive SERS scheme is well suited for the urgent need in pathogen detection and demonstrated great potential in food safety, environment monitoring, and a clinical setting.
Organic Anion Transporting Polypeptide Mediates Organic Anion/HCO3− Exchange (1997)

Organic anion transporting polypeptide (oatp) is an integral membrane protein cloned from rat liver that mediates Na+-independent transport of organic anions such as sulfobromophthalein and taurocholic acid. Previous studies in rat hepatocytes suggested that organic anion uptake is associated with base exchange. To better characterize the mechanism of oatp-mediated organic anion uptake, we examined transport of taurocholate in a HeLa cell line stably transfected with oatp under the regulation of a zinc-inducible promoter (Shi, X., Bai, S., Ford, A. C., Burk, R. D., Jacquemin, E., Hagenbuch, B., Meier, P. J., and Wolkoff, A. W. (1995) J. Biol. Chem. 270, 25591-25595). Whereas noninduced transfected cells showed virtually no uptake of [3H]taurocholate, taurocholate uptake by induced cells was Na+-independent and saturable (Km = 19.4 +/- 3.3 microM; Vmax = 62.2 +/- 1.4 pmol/min/mg protein; n = 3). To test whether organic anion transport is coupled to HCO3- extrusion, we compared the rates of taurocholate-dependent HCO3- efflux from alkali-loaded noninduced and induced cells. Monolayers grown on glass coverslips were loaded with the pH-sensitive dye 2', 7'-bis(carboxyethyl)-5(6)-carboxyfluorescein; intracellular pH (pHi) was measured by excitation ratio fluorometry. Noninduced and induced cells were alkalinized to an equivalent pHi ( approximately 7.7) by transient exposure to a 50 mM HCO3-, Cl--free solution. In the absence of extracellular Cl- and taurocholate, isohydric reduction of superfusate HCO3- concentration from 50 to 25 mM resulted in an insignificant change in pHi over time (dpHi/dt) in both groups. Addition of 25 microM taurocholate to the superfusate led to a rapid fall in pHi in induced (-0.037 +/- 0.011 pH units/min to pHi of 7.41 +/- 0.14) but not in noninduced (0.003 +/- 0.006 pH units/min to pHi of 7.61 +/- 0.08) cells (p < 0.03). These data indicate that oatp-mediated taurocholate transport is Na+-independent, saturable, and accompanied by HCO3- exchange. We conclude that organic anion/base exchange is an important, potentially regulatable component of oatp function.
NaviPoint (1998)

Article Free Access Share on NaviPoint: an input device for mobile information browsing Authors: Kiyokuni Kawachiya IBM Research, Tokyo Research Laboratory, 1623-14, Shimotsuruma, Yamato, Kanagawa 242-8502, Japan IBM Research, Tokyo Research Laboratory, 1623-14, Shimotsuruma, Yamato, Kanagawa 242-8502, JapanView Profile , Hiroshi Ishikawa IBM Research, Tokyo Research Laboratory, 1623-14, Shimotsuruma, Yamato, Kanagawa 242-8502, Japan IBM Research, Tokyo Research Laboratory, 1623-14, Shimotsuruma, Yamato, Kanagawa 242-8502, JapanView Profile Authors Info & Claims CHI '98: Proceedings of the SIGCHI Conference on Human Factors in Computing SystemsJanuary 1998 Pages 1–8https://doi.org/10.1145/274644.274645Published:01 January 1998Publication History 14citation985DownloadsMetricsTotal Citations14Total Downloads985Last 12 Months13Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Initial Results of an Experimental Investigation into the General Application of Transonic Wind Tunnel Wall Corrections (1995)

An experimental study into the rationale of wind tunnel wall correction is under way in an adaptive flexible walled test section at the University of Southampton. The investigation has initially concentrated on deliberately introducing uniform streamwise gradients of Mach number and wall-induced upwash into the vicinity of a two-dimensional aft cambered aerofoil, in order to reveal the sensitivities of the model's aerodynamic behaviour to such flow imperfections. The theoretical preparation and the initial findings of the preliminary aerofoil tests form the subject of this paper. Although current test experience is restricted to a Mach number of 0.6 and a single model attitude a valuable body of data has been generated. The data can not only be used to guide the streamlining policy in an adaptive flexible walled test section but can also aid the application of wall corrections in conventional wind tunnels. Consequently, there is a need to broaden the scope of the investigation in terms of Mach number and incidence and later to different model geometries, including three-dimensional models.
Role of GLI2 in the growth of human osteosarcoma (2011)

The Hedgehog pathway functions as an organizer in embryonic development. Aberrant activation of the Hedgehog pathway has been reported in various types of malignant tumours. The GLI2 transcription factor is a key mediator of Hedgehog pathway but its contribution to neoplasia is poorly understood. To establish the role of GLI2 in osteosarcoma, we examined its expression by real-time PCR using biopsy tissues. To examine the function of GLI2, we evaluated the growth of osteosarcoma cells and their cell cycle after GLI2 knockdown. To study the effect of GLI2 activation, we examined mesenchymal stem cell growth and the cell cycle after forced expression of GLI2. We found that GLI2 was aberrantly over-expressed in human osteosarcoma biopsy specimens. GLI2 knockdown by RNA interferences prevented osteosarcoma growth and anchorage-independent growth. Knockdown of GLI2 promoted the arrest of osteosarcoma cells in G(1) phase and was accompanied by reduced protein expression of the cell cycle accelerators cyclin D1, SKP2 and phosphorylated Rb. On the other hand, knockdown of GLI2 increased the expression of p21(cip1) . In addition, over-expression of GLI2 promoted mesenchymal stem cell proliferation and accelerated their cell cycle progression. Finally, evaluation of mouse xenograft models showed that GLI2 knockdown inhibited the growth of osteosarcoma in nude mice. Our findings suggest that inhibition of GLI2 may represent an effective therapeutic approach for patients with osteosarcoma.
Compact low noise receiving antenna (1998)

The authors report a novel active integrated receiving antenna providing between 12 and 24 dB gain when referred to a passive equivalent at 1.335 GHz. The antenna is of a compact coplanar form, integrating DC and RF requirements to obtain both high gain and low noise.
Characterization of a 180-kDa Intestinal Epithelial Cell Membrane Glycoprotein, gp180 (1997)

Previous studies have shown that normal human intestinal epithelial cells stimulate CD8(+) suppressor T cell proliferation in an allogeneic mixed epithelial/T cell co-culture system, which is neither restricted by class I or class II major histocompatibility complex antigens nor by any soluble factors from epithelial cells. Two epithelial specific monoclonal antibodies (mAb), mAb B9 and mAb L12, are potent inhibitors of this mixed epithelial/T cell reaction but not of conventional mixed lymphocyte reactions. While phenotypically distinct by tissue staining, both mAbs recognize a 180-kDa epithelial membrane glycoprotein (gp180). Further characterization of gp180 revealed the following. 1) The protein migrated between 150 and 180 kDa in SDS-polyacrylamide gel electrophoresis and could be resolved by Western blot using mAb B9 or mAb L12. 2) The molecule has two forms, an apically sorted glycosylphosphatidylinositol-anchored form and a basolateral transmembrane form. 3) gp180 is heavily N-glycosylated, since N-glycanase treatment results in a >50% reduction in size. 4) Purified gp180 can bind to peripheral blood T cells and activate p56(lck). 5) gp180 can activate p56(lck) in 3G8 (a murine T cell hybridoma transfected with human CD8alpha cDNA) but not in 3G4 (CD4 transfectant), suggesting that gp180 binds to CD8. Thus, gp180 appears to be a novel regulator of mucosal immune responses.
The role of superoxide radical in TNF-alpha induced NF-kappaB activation. (1999)

Electron spin resonable (ESR) spin trapping with 5-(diethioxyphosphoyl)-5-methyl-1-pyrroline N-oxide (DEPMPO) was utilized to investigate the generation of oxygen free radicals from macrophages stimulated by tumor necrosis factor-alpha (TNF-alpha). TNF-alpha stimulated macrophages generated hydroxyl (*OH) and superoxide anion (O2*-) radicals. Incubation of TNF-alpha with macrophages resulted in an activation of DNA binding activity of the nuclear transcription factor NF-kappaB. Superoxide dismutase (SOD), but not catalase or sodium formate, inhibited this NF-kappaB activation, suggesting that O2*- rather than H2O2 or *OH, radicals play the most critical role in this induction. beta-Nicotinamide adenine dinucleotide phosphate (NADPH) did not affect the NF-kappaB activation, while allopurinol, an inhibitor of xanthine oxidase, repressed it, suggesting that xanthine/xanthine oxidase, and not NADPH dependent oxidase, may be a source of O2*- radicals which induce NF-kappaB activation. 02*- is generated via reduction of molecular oxygen by xanthine and xanthine oxidase, as demonstrated by the oxygen consumption assay. The results indicate that TNF-alpha induces oxygen radical generation from macrophages. 02*- seems to play a key role in TNF-alpha-induced NF-kappaB activation in macrophages. Xanthine and xanthine oxidase appears to be a source of O2*- radicals responsible for TNF-alpha-induced NF-kappaB activation.
Laser Microdissection‐Mediated Isolation and In Vitro Transcriptional Amplification of Plant RNA (2009)

Protocols for laser microdissection and linear amplification of RNA from fixed, sectioned plant tissues are described. When combined with quantitative RT-PCR, microarray analysis, or RNA-sequencing, these procedures enable quantitative analyses of transcript accumulation from microscopic quantities of specific plant organs, tissues, or single cells.
Optimizing the giant magnetoresistance of symmetric and bottom spin valves (invited) (1996)

We have attempted to optimize the values of the giant magnetoresistance in symmetric spin valves of the type NiO/Co/Cu/Co/Cu/Co/NiO (achieving 23.4%) and in bottom spin valves of the type Co/Cu/Co/NiO (achieving 17.0%), the largest values ever reported for such structures. The key elements in this achievement are improved vacuum conditions and careful attention to the film thicknesses.
Description of the Choquet Integral for tactical knowledge representation (2010)

The goal of Combat Identification (CID), and as well, Situational Awareness (SA), is to combine data and information at the appropriate information representation in order to declare a positive ID according to a classification structure. CID includes the ultimate determination of the intent and prediction of future actions of an object or entity via the establishment of tactical knowledge. To facilitate CID, we utilize the concept of conceptual spaces to represent cooperative and non-cooperative CID. The Choquet integral combined with Bayes risk enables methods that provide a statistical approach to adversary intent prediction through the CID knowledge spaces. The use of the Choquet Integral for CID is applied in the context of a Maritime Domain Awareness (MDA) example.