gebhart/patrepeval huggingface dataset:
A dynamic radio resource management technique for multiple APs in WLANs (2006)

As more and more wireless LANs are deployed in many popular locations, there is a need for dynamic radio resource management (RRM) schemes. This paper proposes a new dynamic RRM technique for multiple APs network. First, we develop a real-time algorithm to estimate the number of active stations from the standpoint of an AP, instead of a station. Second, we propose a dynamic RRM algorithm that not only significantly increases network performance but also reduces the co-channel interference. Third, we find the optimal switching probability that minimizes the transient time for an AP to reach its equilibrium state. For uniform traffic conditions, our scheme produces classical optimal frequency assignments. For non-uniform traffic conditions, it produces sub-optimal frequency assignments. Our simulations have shown that the proposed RRM technique adapts to dynamic network conditions and increases the channel throughput up to 65% in less than 20 iterations. The results can be applied to practical WLANs to significantly improve network performance
Anticancer and Potential Antiviral Activity of Complex Inorganic Compounds (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAnticancer and Potential Antiviral Activity of Complex Inorganic CompoundsStanley Kirschner, Yung-Kang Wei, Dawn Francis, and John G. BergmanCite this: J. Med. Chem. 1966, 9, 3, 369–372Publication Date (Print):May 1, 1966Publication History Published online1 May 2002Published inissue 1 May 1966https://pubs.acs.org/doi/10.1021/jm00321a026https://doi.org/10.1021/jm00321a026research-articleACS PublicationsRequest reuse permissionsArticle Views459Altmetric-Citations170LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Prognostic relevance of Period1 (Per1) and Period2 (Per2) expression in human gastric cancer. (2014)

Period1 (Per1) and Period2 (Per2) are members of the circadian genes. Mounting evidence suggests that the deregulation of the circadian clock plays an important role in the development of mammalian cancer. However, the expression and clinical significance of Per1 and Per2 in gastric cancer is still unexplored. Here, we evaluated the expression pattern of Per1 and Per2 in 246 gastric cancer specimens and their adjacent, non-tumorous tissues using immunohistochemical assays. Per1 expression was significantly associated with clinical stage (p < 0.001), depth invasion (p < 0.001), lymph node metastasis (p < 0.001) and pathologic differentiation (p < 0.001). On the other hand, Per2 was associated with clinical stage (p = 0.021) and depth invasion (p = 0.007). Per1 expression was positively correlated with Per2 expression in the 246 gastric cancer patients (r = 0.378, p < 0.001), and the expression levels of Per1 and Per2 were down-regulated in gastric cancer tissues when compared with adjacent, non-tumorous tissues in 45 gastric cancer samples (p < 0.001, p = 0.003). Patients with lower Per1 and Per2 tumor expression had a shorter survival time than those with higher expression. Univariate and Multivariate analyses indicated that Per2 expression is an independent prognostic factor (p = 0.023). Our results demonstrate that Per1 and Per2 may play important roles in tumor development, invasion and prognosis, and Per2 may serve as a novel prognostic biomarker of human gastric cancer.
Dual inhibition of IGFR and mTOR pathways. (2010)

3007 Background: Mammalian target of rapamycin (mTOR) inhibitors mediate AKT activation through a type I insulin-like growth factor receptor (IGF-1R)-dependent mechanism. Combining the mTOR inhibitor temsirolimus with cixutumumab, a fully humanized IgG1 monoclonal antibody directed at the IGF-IR, was expected to enhance mTOR-targeted anticancer activity by modulating resistance to mTOR inhibition. Objectives of this NCI-CTEP-sponsored R21-funded multicenter clinical trial were to define MTD, biologic effects, antitumor activity and metabolic activity of temsirolimus and cixutumumab, individually and combined. Methods: A “3+3” design used a fixed dose of 25 mg IV weekly of temsirolimus with an escalating weekly dose of IV cixutumumab at 3, 4, and 6 mg/kg with no intrapatient dose escalation. 36 pts with advanced cancer (14 M/ 22 F, median age=54, median # of prior therapies=5) were enrolled across 3 dose cohorts. In cohort 3 (recommended phase II dose of cixutumumab 6 mg/kg IV weekly with FDA-approved dose of temsirolimus 25 mg IV weekly), 21 additional pts were enrolled in three separate groups for serial biopsies and PET scans as part of PD analysis. Results: Most frequent toxicities were hypercholesterolemia, hypertriglyceridemia, hyperglycemia, and mucositis. Two of three pts with Ewing's sarcoma (EWS) had tumor reduction >20%. Antitumor activity (≥ SD) was also noted in adrenalcortical carcinoma, prostate, and breast cancers. Preliminary correlative data suggest that cixutumumab alone or combined with temsirolimus increased plasma IGF-1 and IGF-BP 3. Changes in pAKT and pS6K were observed in tumor biopsy tissue by immunohistochemistry. PET analysis showed one unit increase in absolute value of SUV from baseline to day 11 may decrease the probability of achieving stable disease by 50%. Conclusions: Temsirolimus 25 mg IV weekly combined with cixutumumab 6 mg/kg IV weekly was well tolerated, demonstrating antitumor activity in several tumor types. An increase in SUV of PET at day 11 may predict negative clinical benefit. An expanded cohort of EWS pts will be treated at the FDA-approved dose of temsirolimus at 25 mg IV weekly with the recommended phase II dose of cixutumumab at 6 mg/kg IV weekly. Supported by 5UO1CA062461-14(RK), 5UO1CA062487-17(PL), and 1R21CA13763301A1(AN). Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration ImClone Systems
A Hemodynamic Study of Pulmonary Hypertension in Sickle Cell Disease (2011)

In this study of adults with sickle cell disease, the prevalence of pulmonary hypertension as confirmed on right heart catheterization was 6%. Echocardiographic evaluation alone had a low positive predictive value for pulmonary hypertension. (Funded by the French Ministry of Health and Assistance Publique-Hôpitaux de Paris; ClinicalTrials.gov number, NCT00434902.).
Emerging roles for proteinases in cancer. (1997)

Metalloproteinases and serine proteinases have been associated with tumor invasion and formation of metastasis which represent the major obstacles to cancer cure. The contribution of proteinases in these processes was initially thought to be the destruction of extracellular matrices. However, recent evidence suggests that they mainly affect tumor growth rather than invasion. Proteinases can indeed generate active matrix protein fragments, influence the release, the activation and the bioavailability of growth factors, and consequently modulate tumor cell growth, apoptosis and angiogenesis. Additionally, proteinases, their receptors and/or inhibitors can be directly involved in cell migration and in the processing or shedding of cell surface proteins. Further elucidation of the functions of proteinases is essential for the development of novel anticancer strategies.
Borazine‐CF<sub>3</sub><sup>−</sup> Adducts for Rapid, Room Temperature, and Broad Scope Trifluoromethylation (2017)

A fluoroform-derived borazine CF<sub>3</sub><sup>-</sup> transfer reagent is used to effect rapid nucleophilic reactions in the absence of additives, within minutes at 25 °C. Inorganic electrophiles spanning seven groups of the periodic table can be trifluoromethylated in high yield, including transition metals used for catalytic trifluoromethylation. Organic electrophiles included (hetero)arenes, enabling C-H and C-X trifluoromethylation reactions. Mechanistic analysis supports a dissociative mechanism for CF<sub>3</sub><sup>-</sup> transfer, and cation modification afforded a reagent with enhanced stability.
Design of a Recommendation Filtering System in Mobile Commerce (2009)

This mobile commerce has become a research hotspot in recent years for its commercial value and technical maturity. While more and more service providers participating in mobile commerce promote its popularity, problem called "spam recommendation" decreases users' satisfaction. Therefore, efficient mechanisms should be adopted to improve quality of recommendation. In this paper, a recommendation filtering system is addressed to reduce arbitrary recommendations. The general idea is to record users' operations (called "implicit feedbacks") on recommendation with the form of short message to obtain users' interests and to update user profiles continuously. At the same time when receiving new recommendation, the system computes the similarity between user profile and recommendation message, and then judges whether the message is a spam.
N-acetyl-L-cysteine Exhibits Antitumoral Activity by Increasing Tumor Necrosis Factor α-Dependent T-Cell Cytotoxicity (1997)

Abstract Because of its anticarcinogenic and antimutagenic properties, N-acetyl-L-cysteine (NAC) has been proposed for cancer treatment. Here we present a mechanism of action for NAC in cancer. Our data show that NAC (1) induces an early and sustained increase of membrane tumor necrosis factor α (TNFα) expression on human stimulated-peripheral blood (PB) T cells and (2) increases membrane TNF-RI and TNF-RII on tumoral cell lines and on T cells after stimulation. These effects result from an early inhibition of both TNFα and TNF-R shedding, as well as a later increase of the respective mRNA expression. Consequently, NAC confers cytotoxic properties to human PB T cells through a membrane TNFα-dependent pathway. In vivo, NAC given orally inhibits tumor appearance in more than a third (18 out of 50) B6D2F1 mice injected with L1210 lymphoma cells. Spleen cells from protected mice killed L1210 lymphoma cells in vitro in a membrane TNFα-dependent manner. Furthemore these mice were resistant to a second inoculation of L1210 cells without further treatment with NAC. Thus, NAC exhibits a potent antitumoral activity by modulating TNFα and TNF-R processing without showing any in vitro and in vivo toxicity.
<title>Agile optical beam scanners using wavelength and space manipulations</title> (2001)

An agile optical scanning scheme is proposed that uses wavelength manipulations for deflecting a free-space optical beam by selection of the wavelength of the light incident on a wavelength dispersive optical element. Using fast tunable lasers or optical filters, this scanner features microsecond domain scan setting speeds, single/multiple beam(s) in space, and large several centimeters or more diameter apertures for sub-degree angular scans. The beam scanning scheme offers simple control (via wavelength tuning). The paper also introduces space multiplexing for optical beam scanning and discusses various system architectures utilizing both space and wavelength multiplexing to achieve high speed optical scanning with coarse and fine tuning capability. Experiments described demonstrate high-speed, high resolution, wavelength tuned optical scanning in one-dimension (1-D), two-dimensions (2-D), and three-dimensions (3-D).
Analytic description of short-channel effects in fully-depleted double-gate and cylindrical, surrounding-gate MOSFETs (2000)

Short-channel effects in fully-depleted double-gate (DG) and cylindrical, surrounding-gate (Cyl) MOSFETs are governed by the electrostatic potential as confined by the gates, and thus by the device dimensions. The simple but powerful evanescent-mode analysis shows that the length /spl lambda/, over which the source and drain perturb the channel potential, is 1//spl pi/ of the effective device thickness in the double-gate case, and 1/4.810 of the effective diameter in the cylindrical case, in excellent agreement with PADRE device simulations. Thus for equivalent silicon and gate oxide thicknesses, evanescent-mode analysis indicates that Cyl-MOSFETs can be scaled to 35% shorter channel lengths than DG-MOSFETs.
Sol‐Gel‐Derived Sb‐Doped SnO<sub>2</sub> Nanoparticles Controlled in Size by Nb<sub>2</sub>O<sub>5</sub> (2003)

Abstract Nanocrystalline Sb‐doped SnO 2 particles were prepared by sol‐gel and their particle growth was controlled by niobium oxide. In the present synthesis, SnCl 4 and SbCl 3 , as precursors, were dissolved and hydrolyzed in ethylene glycol at 80–120 °C, and further 0.1 mol.‐% Nb 2 O 5 through its precursor NbCl 5 was mixed to the above solution. The mixture was then dried at 120–150 °C and calcinated at 600 °C for 2 hours. By XRD and TEM, Sb‐doped SnO 2 nanoparticles were highly crystalline and their mean crystal size was ca.10–20 nm with narrow particle size distribution. As the addition of antimony increased, the crystallinity and particle size distribution of SnO 2 particles had the trend to decrease.
In Situ Measurements Of Corona Poling Induced SHG In Amorphous Polymers (1988)

In this paper we report for the first time in-situ measurements of corona poling induced SHG . We investigated a specially synthesized new amorphous polymer (PPNA) that contains p-nitroaniline as sidegroups covalently fixed to a polyethylene-type backbone. In addition, we did measurements on an amorphous alternating copolymer poly(vinylidenecyanide/vinyl-acetate) (PVDCN/VAc), known for its piezoelectric properties. In order to understand the nonlinear properties and their stability, an extensive characterization of the materials is necessary. Therefore, calorimetry, thermogravimetry, X-ray, dielectric relaxation, waveguide and absorption spectroscopy studies were performed. Fig. 1 shows the chemical structure of the polymers investigated.
The use of time‐lapse P‐wave impedance inversion to monitor CO<sub>2</sub>flood at Weyburn Field, Saskatchewan, Canada (2003)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 2003The use of time‐lapse P‐wave impedance inversion to monitor CO 2 flood at Weyburn Field, Saskatchewan, CanadaAuthors: Ida HerawatiThomas L. DavisIda HerawatiColorado School of Mines, Golden, CO and Thomas L. DavisColorado School of Mines, Golden, COhttps://doi.org/10.1190/1.1817538 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1817538FiguresReferencesRelatedDetailsCited byAdvances in enhanced oil recovery technologies for low permeability reservoirsPetroleum Science, Vol. 5Time-lapse acoustic impedance variations during CO2 injection in Weyburn oilfield, CanadaYichuan Wang and Igor B. Morozov22 November 2019 | GEOPHYSICS, Vol. 85, No. 1Time-Lapse Monitoring of CO2 Response at Ankleshwar Oil Field: A Seismic Modeling Approach for Feasible CO2-EOR and Storage2 April 2017Azimuthal multi‐attribute analysis for fracture properties in time lapse VSP dataIsabel Varela, Enru Liu, and Mark Chapman6 October 2006 SEG Technical Program Expanded Abstracts 2003ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 2003 Pages: 2452 publication data© 2003 Copyright © 2003 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 03 Jan 2005 CITATION INFORMATION Ida Herawati and Thomas L. Davis, (2003), "The use of time‐lapse P‐wave impedance inversion to monitor CO 2 flood at Weyburn Field, Saskatchewan, Canada," SEG Technical Program Expanded Abstracts : 1350-1353. https://doi.org/10.1190/1.1817538 Plain-Language Summary PDF DownloadLoading ...
Genetic Factors Associated with Elevated Carbapenem Resistance in KPC-Producing <i>Klebsiella pneumoniae</i> (2010)

In the United States, the most prevalent mechanism of carbapenem resistance among Enterobacteriaceae is the production of a Klebsiella pneumoniae carbapenemase (KPC). KPC-producing isolates often exhibit a range of carbapenem MICs. To better understand the factors that contribute to overall carbapenem resistance, we analyzed 27 KPC-producing K. pneumoniae isolates with different levels of carbapenem resistance, 11 with low-level (i.e., meropenem or imipenem MIC ≤ 4 μg/ml), 2 with intermediate-level (i.e., meropenem and imipenem MIC = 8 μg/ml), and 14 with high-level (i.e., imipenem or meropenem MIC ≥ 16 μg/ml) carbapenem resistance, that were received from throughout the United States. Among 14 isolates that exhibited high-level carbapenem resistance, Western blot analysis indicated that 10 produced an elevated amount of KPC. These isolates either contained an increased bla(KPC) gene copy number (n = 3) or had deletions directly upstream of the bla(KPC) gene (n = 7). Four additional isolates lacked elevated KPC production but had high-level carbapenem resistance. Porin sequencing analysis identified 22 isolates potentially lacking a functional OmpK35 and three isolates potentially lacking a functional OmpK36. The highest carbapenem MICs were found in two isolates that lacked both functioning porins and produced elevated amounts of KPC. The 11 isolates with low-level carbapenem resistance contained neither an upstream deletion nor increased bla(KPC) copy number. These results suggest that both bla(KPC) copy number and deletions in the upstream genetic environment affect the level of KPC production and may contribute to high-level carbapenem resistance in KPC-producing K. pneumoniae, particularly when coupled with OmpK36 porin loss.
Efficacy of fibrin glue for in vitro sealing of human chorioamniotic membranes. (1998)

Fibrin glue effectively improved the structural integrity of artificially punctured chorioamniotic membranes.
Human adipose-tissue derived mesenchymal stem cells induce functional <i>de-novo</i> regulatory T cells with methylated FOXP3 gene DNA (2013)

Due to their immunomodulatory properties, mesenchymal stem cells (MSC) are interesting candidates for cellular therapy for autoimmune disorders, graft-versus-host disease and allograft rejection. MSC inhibit the proliferation of effector T cells and induce T cells with a regulatory phenotype. So far it is unknown whether human MSC-induced CD4(+) CD25(+) CD127(-) forkhead box P3 (FoxP3)(+) T cells are functional and whether they originate from effector T cells or represent expanded natural regulatory T cells (nT(reg)). Perirenal adipose-tissue derived MSC (ASC) obtained from kidney donors induced a 2·1-fold increase in the percentage of CD25(+) CD127(-) FoxP3(+) cells within the CD4(+) T cell population from allostimulated CD25(-/dim) cells. Interleukin (IL)-2 receptor blocking prevented this induction. The ASC-induced T cells (iT(reg)) inhibited effector cell proliferation as effectively as nT(reg). The vast majority of cells within the iT(reg) fraction had a methylated FOXP3 gene T(reg)-specific demethylated region (TSDR) indicating that they were not of nT(reg) origin. In conclusion, ASC induce T(reg) from effector T cells. These iT(reg) have immunosuppressive capacities comparable to those of nT(reg). Their induction is IL-2 pathway-dependent. The dual effect of MSC of inhibiting immune cell proliferation while generating de-novo immunosuppressive cells emphasizes their potential as cellular immunotherapeutic agent.
Family History and the Risk of Breast Cancer (1985)

To investigate whether a family history of breast cancer increases a woman's risk of developing breast cancer, we analyzed data from the Centers for Disease Control's Cancer and Steroid Hormone Study. The 4,735 cases were women 20 to 54 years old with a first diagnosis of breast cancer ascertained from eight population-based cancer registries; the 4,688 controls were women selected at random from the general population of these eight areas. Compared with women without a family history of breast cancer, women who had an affected first-degree relative had a relative risk of 2.3; women with an affected second-degree relative had a relative risk of 1.5; and women with both an affected mother and sister had a relative risk of 14. The risk of breast cancer for a woman was higher if her first-degree relative had unilateral rather than bilateral breast cancer or had breast cancer detected at a younger rather than older age. For women aged 20 to 39, 40 to 44, and 45 to 54 years, the estimated annual incidence of breast cancer per 100,000 women attributable to a first-degree family history of breast cancer was 51.9, 115.1, and 138.6, respectively, and that attributable to a second-degree family history of breast cancer was 12.1, 19.2, and 92.4, respectively.
Cytoplasmic Cyclin E Predicts Recurrence in Patients with Breast Cancer (2016)

<b>Purpose:</b> Low molecular weight cyclin E (LMW-E) detected by Western blot analysis predicts for reduced breast cancer survival; however, it is impractical for clinical use. LMW-E lacks a nuclear localization signal that leads to accumulation in the cytoplasm that can be detected by IHC. We tested the hypothesis that cytoplasmic staining of cyclin E can be used as a predictor of poor outcome in different subtypes of breast cancer using patient cohorts with distinct clinical and pathologic features.<b>Experimental Design:</b> We evaluated the subcellular localization of cyclin E in breast cancer specimens from 2,494 patients from 4 different cohorts: 303 from a prospective study and 2,191 from retrospective cohorts [NCI, MD Anderson Cancer Center (MDA), and the United Kingdom (UK)]. Median follow-up times were 8.0, 10.1, 13.5, and 5.7 years, respectively.<b>Results:</b> Subcellular localization of cyclin E on IHC was associated with full-length (nuclear) and low molecular weight isoforms (cytoplasmic) of cyclin E on Western blot analysis. In multivariable analysis, cytoplasmic cyclin E staining was associated with the greatest risk of recurrence compared with other prognostic factors across all subtypes in three (NCI, MDA, and UK) of the cohorts. In the MDA cohort, cytoplasmic cyclin E staining outperformed Ki67 and all other variables as prognostic factors.<b>Conclusions:</b> Cytoplasmic cyclin E identifies patients with the highest likelihood of recurrence consistently across different patient cohorts and subtypes. These patients may benefit from alternative therapies targeting the oncogenic isoforms of cyclin E. <i>Clin Cancer Res; 23(12); 2991-3002. ©2016 AACR</i>.
FPGA-based implementation and comparison of recursive and iterative algorithms (2005)

The paper analyses and compares alternative iterative and recursive implementations of FPGA circuits for various problems. Two types of recursive calls have been examined, namely for cyclic and binary (N-ary) search algorithms. The details of experiments are presented for four different design problems. The relevant comparative data have been obtained as a result of synthesis and implementation in FPGAs of the respective circuits from system-level (Handel-C) and RTL (VHDL) specifications.