gebhart/patrepeval huggingface dataset:
An Ion-Sensitive Floating Gate FET Model: Operating Principles and Electrofluidic Gating (2015)

We present a model that can be used to compute the charging and potential at any point of the electrochemical system comprising the ion-sensitive floating gate FET (ISFGFET) exposed to an electrolyte solution. In contrast to ion-sensitive FETs, the sensor has an additional control input gate. The model predicts the possibility for electrofluidic gating when the control gate (CG) is used in conjunction with a reference electrode (RE). Electrofluidic gating is the field-effect control over the electric double layer. We consider the applicability of electrofluidic gating in realizable devices and simulate the relationships between oxide properties and electrolyte solution to varying potentials of the CG and the RE. The oxide/electrolyte solution model is merged to the SPICE model of the transistor to create a unified model that can be used to simulate the transfer characteristics of the sensor in absolute terms to change input and electrolyte solution conditions. We simulate the sensor transfer characteristics with common Al2O3 surface to change the pH of the electrolyte solution and compare them to measurements. The results clarify the operation of ISFGFET and its applicability in electrofluidic gating.
Removal of transition metals from rare earths by solvent extraction with an undiluted phosphonium ionic liquid: separations relevant to rare-earth magnet recycling (2013)

An environmentally friendly process for the separation of the transition metals copper, cobalt, iron, manganese and zinc from rare earths by solvent extraction with the ionic liquid trihexyl(tetradecyl)phosphonium chloride has been developed. The solvent extraction process is carried out without the use of organic diluents or extra extraction agents and it can be applied as a sustainable hydrometallurgical method for removing transition metals from neodymium–iron–boron or samarium–cobalt permanent magnets. The recycling of rare earths is of high importance because of the possible supply risk of these elements in the near future. The method was tested for the removal of cobalt and iron from samarium and neodymium, respectively. The highest distribution ratios for cobalt and iron were found with 8.5 and 9 M HCl. At the tested conditions, the concentrations of neodymium and samarium in the ionic liquid were below 0.5 mg L−1 (0.5 ppm), even for feed concentrations of 45 g L−1. The separation factors of Nd/Fe and Sm/Co are 5.0 × 106 and 8.0 × 105, respectively. The percentage extraction of iron is still higher than 99.98% at loadings of the ionic liquids with 70 g L−1 of iron. The viscosity of the ionic liquid containing the tetrachloroferrate(III) complex [FeCl4]− is lower, and less depending on the feed concentration, than in the case with a tetrachlorocobaltate(II) anion [CoCl4]2−. After extraction, cobalt can be stripped very easily from the ionic liquid phase with water. However, due to the very high distribution ratio, iron could only be stripped by forming a water-soluble iron complex with ethylenediaminetetraacetic acid (EDTA). Also the possibility to extract chromium, nickel, aluminium, calcium and magnesium with trihexyl(tetradecyl)phosphonium chloride has been investigated, but the distribution ratios of these elements are very low in the tested conditions.
SELENIUM AS AN INTEGRAL PART OF FACTOR 3 AGAINST DIETARY NECROTIC LIVER DEGENERATION (1957)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSELENIUM AS AN INTEGRAL PART OF FACTOR 3 AGAINST DIETARY NECROTIC LIVER DEGENERATIONKlaus Schwarz and Calvin M. FoltzCite this: J. Am. Chem. Soc. 1957, 79, 12, 3292–3293Publication Date (Print):June 1, 1957Publication History Published online1 May 2002Published inissue 1 June 1957https://pubs.acs.org/doi/10.1021/ja01569a087https://doi.org/10.1021/ja01569a087research-articleACS PublicationsRequest reuse permissionsArticle Views1637Altmetric-Citations1334LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Plasmapheresis and antineoplastic treatment in CNS paraneoplastic syndromes with antineuronal autoantibodies (1992)

We retrospectively evaluated the effect of plasmapheresis (PE) in seven patients with paraneoplastic encephalomyelitis (PEM), small-cell lung carcinoma, and anti-Hu antibodies, and four patients with paraneoplastic cerebellar degeneration (PCD), ovarian or breast cancer, and anti-Yo antibodies. In addition to PE, patients received prednisone (nine), cyclophosphamide (eight), or treatment of the tumor (five). All but one patient were severely disabled by the time PE began. The clinical outcome was compared with that of five patients (PEM, four; PCD, one) who only had treatment of the tumor. Only one of these five patients had a severe neurologic deficit at the onset of the antineoplastic treatment. No patient improved. Two patients treated with PE and antineoplastic therapy and three who only received treatment of the tumor remained stable for at least 6 months. Four of the five patients with a stable course started the treatment when the neurologic deficit was not severe. We conclude that the efficacy of PE with other immunosuppressive therapies in the stabilization of the neurologic deficit is uncertain.
Alkylation and Michael additions of glycine ethyl ester. Use in .alpha.-amino acid synthesis and as acyl carbanion equivalent (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAlkylation and Michael additions of glycine ethyl ester. Use in .alpha.-amino acid synthesis and as acyl carbanion equivalentGilbert Stork, Ambrose Y. W. Leong, and Anne M. TouzinCite this: J. Org. Chem. 1976, 41, 21, 3491–3493Publication Date (Print):October 1, 1976Publication History Published online1 May 2002Published inissue 1 October 1976https://pubs.acs.org/doi/10.1021/jo00883a044https://doi.org/10.1021/jo00883a044research-articleACS PublicationsRequest reuse permissionsArticle Views1973Altmetric-Citations190LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Halo- and Azidodediazoniation of Arenediazonium Tetrafluoroborates with Trimethylsilyl Halides and Trimethylsilyl Azide and Sandmeyer-Type Bromodediazoniation with Cu(I)Br in [BMIM][PF<sub>6</sub>] Ionic Liquid (2007)

Reaction of [ArN(2)][BF(4)] salts immobilized in [BMIM][PF(6)] ionic liquid (IL) with TMSX (X = I, Br) and TMSN(3) represents an efficient method for the preparation of iodo-, bromo-, and azido-derivatives via dediazoniation. The reactions can also be effected starting with ArNH(2) by in situ diazotization with [NO][BF(4)] followed by reaction with TMSX or TMSN(3). Depending on the substituents on the benzenediazonium cation, competing fluorodediazoniation (ArF formation) and hydrodediazoniation (ArH formation) were observed. Dediazoniation with TMSN(3) and with TMSI generally gave the highest chemoselectivity toward ArN(3) and ArI formation. The IL was recycled and reused up to 5 times with no appreciable decrease in the conversions. Multinuclear NMR monitoring of the interaction of [ArN(2)][BF(4)]/TMSX, [BMIM][PF6]/TMSX, and [BMIM][PF(6)]/TMSX/[ArN(2)][BF(4)] indicated that TMSF is formed primarily via [ArN(2)][BF(4)]/TMSX, generating [ArN(2)][X] in situ, which gives ArX on dediazoniation. Competing formation of ArF in Sandmeyer-type bromodediazoniation of [ArN(2)][BF(4)] with Cu(I)Br immobilized in the IL points to significant involvement of heterolytic dediazoniation.
Similarity-Preserving Knowledge Distillation (2019)

Knowledge distillation is a widely applicable technique for training a student neural network under the guidance of a trained teacher network. For example, in neural network compression, a high-capacity teacher is distilled to train a compact student; in privileged learning, a teacher trained with privileged data is distilled to train a student without access to that data. The distillation loss determines how a teacher's knowledge is captured and transferred to the student. In this paper, we propose a new form of knowledge distillation loss that is inspired by the observation that semantically similar inputs tend to elicit similar activation patterns in a trained network. Similarity-preserving knowledge distillation guides the training of a student network such that input pairs that produce similar (dissimilar) activations in the teacher network produce similar (dissimilar) activations in the student network. In contrast to previous distillation methods, the student is not required to mimic the representation space of the teacher, but rather to preserve the pairwise similarities in its own representation space. Experiments on three public datasets demonstrate the potential of our approach.
The evaluation of photo/e-beam complementary grayscale lithography for high topography 3D structure (2013)

This article demonstrates and evaluates the feasibility of photo/e-beam grayscale complementary lithography processes for the fabrication of large area, high topography grayscale structure. The combination of these two techniques capitalizes on the capability of photolithography to generate large three-dimensional structures and the ability of e-beam lithography to add fine structure while maintaining high vertical resolution. The litho-etching-litho-etching process reduces the challenges associated with the etching process when transferring fine features simultaneously with deep substrate etching. As a result, this approach enables the fabrication of large-scale high topography features with fine detail. In the first lithography step, a large staircase is fabricated by direct write photolithography. After the photolithography pattern has been transferred into the substrate, e-beam resist is deposited on the patterned substrate using spray coating to obtain conformal coverage on the deep stepped structure. In the second exposure step, an e-beam system further patterns the steps with finer features. Only a small number of grayscale levels are exposed which simplifies the required proximity correction in the design. A vertical resolution of 25 ± 5 nm in a 600 nm horizontal dimension and 45 ± 6 nm in a 300 nm horizontal feature are achieved over a 2 μm to 30 μm vertical depth range. The alignment strategy of complementary lithography, overlay error, and process optimization of integrating high topography and grayscale structure are discussed.
Recent advances in memory consistency models for hardware shared memory systems (1999)

The memory consistency model of a shared memory system determines the order in which memory operations will appear to execute to the programmer. The memory consistency model for a system typically involves a tradeoff between performance and programmability. The paper provides an overview of recent advances in hardware optimizations; compiler optimizations, and programming environments relevant to memory consistency models of hardware distributed shared memory systems. We discuss recent hardware and compiler optimizations that exploit the observation that it is sufficient to only appear as if the ordering rules of the consistency model are obeyed. These optimizations substantially improve the performance of the strictest consistency model, making it more attractive for its programmability. Recent concurrent programming languages and environments, on the other hand, support more relaxed consistency models. We discuss several such environments, including POSIX threads, Java, and OpenMP.
Inhibition of Glutathione and Thioredoxin Metabolism Enhances Sensitivity to Perifosine in Head and Neck Cancer Cells (2009)

The hypothesis that the Akt inhibitor, perifosine (PER), combined with inhibitors of glutathione (GSH) and thioredoxin (Trx) metabolism will induce cytotoxicity via metabolic oxidative stress in human head and neck cancer (HNSCC) cells was tested. PER induced increases in glutathione disulfide (%GSSG) in FaDu, Cal-27, and SCC-25 HNSCCs as well as causing significant clonogenic cell killing in FaDu and Cal-27, which was suppressed by simultaneous treatment with N-acetylcysteine (NAC). An inhibitor of GSH synthesis, buthionine sulfoximine (BSO), sensitized Cal-27 and SCC-25 cells to PER-induced clonogenic killing as well as decreased total GSH and increased %GSSG. Additionally, inhibition of thioredoxin reductase activity (TrxRed) with auranofin (AUR) was able to induce PER sensitization in SCC-25 cells that were initially refractory to PER. These results support the conclusion that PER induces oxidative stress and clonogenic killing in HNSCC cells that is enhanced with inhibitors of GSH and Trx metabolism.
NR2B‐NMDA receptor‐mediated increases in intracellular Ca<sup>2+</sup>concentration regulate the tyrosine phosphatase, STEP, and ERK MAP kinase signaling (2010)

NMDA receptors regulate both the activation and inactivation of the extracellular signal-regulated kinase (ERK) signaling cascade, a key pathway involved in neuronal plasticity and survival. This bi-directional regulation of ERK activity by NMDA receptors has been attributed to opposing actions of NR2A- versus NR2B-containing NMDA receptors, but how this is implemented is not understood. Here, we show that glutamate-mediated intracellular Ca(2+) increases occur in two phases, a rapid initial increase followed by a delayed larger increase. Both phases of the Ca(2+) increase were blocked by MK-801, a non-selective NMDA receptor inhibitor. On the other hand, selective inhibition of NR2B-NMDA receptors by Ifenprodil or Ro 25-6981 blocked the delayed larger phase but had only a small effect on the rapid initial increase. The rapid initial increase in Ca(2+), presumably because of NR2A-NMDAR activation, was sufficient to activate ERK, whereas the large delayed increases in Ca(2+) mediated by NR2B-NMDARs were necessary for dephosphorylation and subsequent activation of striatal-enriched phosphatase, a neuron-specific tyrosine phosphatase that in turn mediates the dephosphorylation and inactivation of ERK. We conclude that the magnitude of Ca(2+) increases mediated through NR2B-NMDA receptors plays a critical role in the regulation of the serine/threonine and tyrosine kinases and phosphatases that are involved in the regulation of ERK activity.
Characteristics of Glottic Closure Reflex in a Canine Model (2009)

Deepened level of anesthesia affects central facilitation and results in the loss of the crossed adductor reflex, predisposing to a weakened glottic closure response. Precise understanding of this effect may possibly provide a way to prevent aspiration in unconscious patients.
Atomic layer deposition of zinc indium sulfide films: Mechanistic studies and evidence of surface exchange reactions and diffusion processes (2012)

The authors present the elaboration of zinc indium sulfide (ZnInxSy) thin films in the context of a cadmium-free buffer layer development for copper indium gallium diselenide photovoltaic solar cells. The films were deposited by atomic layer deposition (ALD) from ZnEt2 (DEZ), In(acac)3 (acac = acetylacetonate), and H2S at 200 °C. In situ growth kinetics studies were performed with the quartz crystal microbalance technique to determine the respective mass gain per cycle of ZnS and In2S3 layers, allowing determination of the atomic compositions of the ZnInxSy thin films to be expected if the deposition strictly follows the rule of mixtures. As the experimental atomic compositions of the ZnInxSy films differ significantly from this rule, a comprehensive study of the growth mechanism was performed to determine the nature of the side reactions. First, an exchange reaction between In2S3 and the Zn precursor was identified, though this process is not sufficient to account for the experimental data, and therefore, a second process which corresponds to the diffusion of species within the film was also found to take place. Ultimately, the atomic compositions of the ZnInxSy films can be explained by a rate-limited exchange reaction at the surface between DEZ and the In2S3 layer, combined with diffusion of the species in the whole film. More generally, such side reactions should be considered in ALD of multinary compounds, even at low temperature.
Marker assisted elucidation of the origin of 2n-gametes in diploid potato (1997)

This thesis describes the selection and evaluation of diploid potato clones (2n=2x=24) that produce unreduced or 2n-gametes with 24 chromosomes instead of the normal reduced n-gametes with 12 chromosomes. To elucidate the modes of origin of the 2n-gametes, the progenies derived from such gametes were analysed for different marker loci of one chromosome. Besides the already known mechanisms of First and Second Division Restitution (FDR and SDR) in potato, the multilocus analysis showed the additional mechanism of Post-Meiotic Restitution (PMR) resulting in completely homozygous 2n-gametes. The FDR and SDR 2n-gametes were used for gene-centromere mapping. Multilocus analysis of SDR 2n-gametes showed the map position of the centromere of chromosome 8 in relation to the RFLP-loci. These genetic analyses also demonstrated the occurrence of a single crossover per chromosome arm (high level of chiasma interference). In the light of these findings, it is possible to construct more critical genetic maps of potato.
[Can the training of coronary patients be monitored by readily measurable parameters?]. (1991)

The prognosis of coronary patients in terms of the mortality of coronary heart disease shows a positive relation to the severity of clinical and functional diagnostic parameters. Thus exercise therapy should be monitored by criteria that take ischemia, the myocardial situation and rhythm disorders into account. These criteria should be reliable and should be easy to determine as well as to apply. For pragmatic reasons the non-invasive evaluation of findings and the diagnostic symptom-limited ergometer test are especially significant for dosage and monitoring of exercise therapy. Monitored exercise therapy is here understood to mean individually adjusted exercising by patients, and training thus has to be based on diagnostic findings. First existing complaints have to be analyzed and such findings as size of infarction in the ECG, heart volume in the X-ray, size and function of the left ventricle by echography, etc. checked. Afterwards maximum physical work capacity on a multistage bicycle ergometer test is measured with respect to the following termination criteria: a) subjective reports by the patient during exercise (e.g. onset and severity of angina pectoris, dyspnea and/or fatigue of the leg muscles) and b) objective criteria such as significant ischemic ST-depression, exercise-hypertension, age-related submaximal heart rate and significant rhythm disorders. An inverse correlation is found between measured maximum symptom-limited physical performance and the frequency of cardiac termination criteria; a comparable inverse correlation exists with heart volume: max. O2 pulse.(ABSTRACT TRUNCATED AT 250 WORDS)
Examination Of Thermally Efficient Steam Injection Techniques For Deep Reservoirs (1979)

Abstract The physical phenomena which limit the depth for economic enhanced recovery of heavy oil by steam injection are individually examined. The ability of techniques for thermally efficient delivery of surface generated steam to address these phenomena is analyzed. Experimental test facilities for comparison of various approaches to improving thermal efficiency developed through the Department of Energy's Project DEEP STEAM are described. Introduction The enhancement of oil production through steam injection has been applied to a variety of heavy oil reservoirs. The most economically successful application has been to shallow reservoirs (less than 1000 ft in depth) that are pressure depleted. The reservoirs are responsive to steam enhanced recovery and account for practically all the current domestic production. It has been demonstrated that production. It has been demonstrated that steam drive recovery can be successful to depths of 2500 - 3000 ft (760 - 915 m) however, the production costs are much greater than for the shallow reservoirs. The increase in cost of drilling and completing deeper wells accounts for only a small fraction of total cost increase with depth. A variety of physical effects contribute to reduction in physical effects contribute to reduction in the efficiency of production, these includegreater heat loss during deliveryloss of steam quality at the sand face,reduction in specific volume of the vapor phase,change in the two phase enthalpy distribution, andlower permeability of reservoirs. Some of these effects can be addressed by modifications of existing steam injection technology. The first two of the above effects can be reduced by application of thermally efficient injection techniques. The work described in this paper is part of the Department of Energy's Project part of the Department of Energy's Project DEEP STEAM. The objective of the project is to reduce the Cost of steam recovery from deep reservoirs through application of technology. There are several tasks covered by the project, including modification of delivery processes for surface generated steam and development of methods for production of steam at the sand face. This paper will initially examine the physical processes which contribute to increased production cost with depth, then will present test facilities developed through the DEEP STEAM, project for comparative testing and project for comparative testing and development of components for improving the thermal efficiency of well completions.
Stochastic Constraint Programming as Reinforcement Learning (2017)

Stochastic Constraint Programming (SCP) is an extension of Constraint Programming (CP) used for modelling and solving problems involving constraints and uncertainty. SCP inherits excellent modelling abilities and filtering algorithms from CP, but so far it has not been applied to large problems. Reinforcement Learning (RL) extends Dynamic Programming to large stochastic problems, but is problem-specific and has no generic solvers. We propose a hybrid combining the scalability of RL with the modelling and constraint filtering methods of CP. We implement a prototype in a CP system and demonstrate its usefulness on SCP problems.