gebhart/patrepeval huggingface dataset:
NO-donating aspirin induces phase II enzymes in vitro and in vivo (2005)

Modulation of drug metabolizing enzymes, leading to facilitated elimination of carcinogens represents a successful strategy for cancer chemoprevention. Nitric oxide-donating aspirin (NO-ASA) is a promising agent for the prevention of colon and other cancers. We studied the effect of NO-ASA on drug metabolizing enzymes in HT-29 human colon adenocarcinoma and Hepa 1c1c7 mouse liver adenocarcinoma cells and in Min mice treated with NO-ASA for 3 weeks. In these cell lines, NO-ASA induced the activity and expression of NAD(P)H:quinone oxireductase (NQO) and glutathione S-transferase (GST). Compared with untreated Min mice, NO-ASA increased in the liver the activity (nmol/min/mg; mean+/-SEM for all) of NQO (85+/-6 versus 128+/-11, P<0.05) and GST (2560+/-233 versus 4254+/-608, P<0.005) and also in the intestine but not in the kidney; the expression of NQO1 and GST P1-1 was also increased. NO-ASA had only a marginal effect on P450 1A1 and P450 2E1, two phase I enzymes. The release of NO from NO-ASA, determined with a selective microelectrode was paralleled by the induction of NQO1 and abrogated by NO scavengers; an exogenous NO donor also induced the expression of NQO1. NO-ASA induced concentration-dependently the translocation of Nrf2 into the nucleus as documented by immunofluorescence and immunoblotting; this paralleled the induction of NQO1 and GST P1-1. Thus NO-ASA induces phase II enzymes, at least in part, through the action of NO that it releases and by modulating the Keap1-Nrf2 pathway; this effect may be part of its mechanism of action against colon and other cancers.
A peptide hormone gene, <i>Gh<scp>PSK</scp></i> promotes fibre elongation and contributes to longer and finer cotton fibre (2014)

Cotton fibres, the single-celled trichomes derived from the ovule epidermis, provide the most important natural material for the global textile industry. A number of studies have demonstrated that regulating endogenous hormone levels through transgenic approaches can improve cotton fibre qualities. Phytosulfokine-α (PSK-α) is a novel peptide hormone in plants that is involved in regulating cell proliferation and elongation. However, its potential applications in crop genetic improvement have not been evaluated. In this study, we describe how exogenous PSK-α application promotes cotton fibre cell elongation in vitro. Chlorate, an effective inhibitor of peptide sulfation, suppressed fibre elongation in ovule culture. Exogenously applied PSK-α partly restored the chlorate-induced suppression. A putative PSK gene (GhPSK) was cloned from Gossypium hirsutum. Expression pattern analysis revealed that GhPSK is preferentially expressed in rapidly elongating fibre cells (5-20 days postanthesis). Overexpression of GhPSK in cotton increased the endogenous PSK-α level and promoted cotton fibre cell elongation, resulting in longer and finer fibres. Further results from electrophysiological and physiological analyses suggest that GhPSK affects fibre development through regulation of K(+) efflux. Digital gene expression (DGE) profile analysis of GhPSK overexpression lines indicates that PSK signalling may regulate the respiratory electron-transport chain and reactive oxygen species to affect cotton fibre development. These results imply that peptide hormones are involved in cotton fibre growth and suggest a new strategy for the biotechnological improvement of cotton fibre quality.
Zinc in Wound Healing Modulation (2017)

Wound care is a major healthcare expenditure. Treatment of burns, surgical and trauma wounds, diabetic lower limb ulcers and skin wounds is a major medical challenge with current therapies largely focused on supportive care measures. Successful wound repair requires a series of tightly coordinated steps including coagulation, inflammation, angiogenesis, new tissue formation and extracellular matrix remodelling. Zinc is an essential trace element (micronutrient) which plays important roles in human physiology. Zinc is a cofactor for many metalloenzymes required for cell membrane repair, cell proliferation, growth and immune system function. The pathological effects of zinc deficiency include the occurrence of skin lesions, growth retardation, impaired immune function and compromised would healing. Here, we discuss investigations on the cellular and molecular mechanisms of zinc in modulating the wound healing process. Knowledge gained from this body of research will help to translate these findings into future clinical management of wound healing.
A planar single-substrate AC plasma display (1976)

A novel method is described for constructing an acsustained gas-discharge display (plasma panel). Electrodes and insulating layers are applied alternatively on a single base substrate to produce a matrix of insulated crossovers. A second clear substrate is used to contain gas on the electrode side of the base substrate where glow discharge occurs. As in conventional two-substrate panels, internal memory is obtained by charge storage on the dielectric. The pulsed write and the sustain mechanisms of single- and twin-substrate display elements are discussed with regard to the effects of cell and field geometries. In the sustain mode, glow-propagation effects are observed, especially in the nonhomogeneous fields of the single-substrate design. Here cathode-type glows which form a narrow band are observed with a high-speed photomultiplier and shown to sweep across the dielectric surfaces. Luminance, intensity distributions, and luminous efficiency data are compared on small 10 × 10-line panels using single-substrate and conventional designs. A three- to four-fold improvement in luminance is achieved with the single-substrate geometry.
An open-label, phase 1 study evaluating safety, tolerability, and pharmacokinetics of linifanib (ABT-869) in Japanese patients with solid tumors (2012)

Linifanib was well tolerated with promising preliminary clinical activity in Japanese patients. Later-phase global studies examining linifanib efficacy will include Japanese patients.
Normalization of relations and PROLOG (1986)

A program for the normalization of relations that is written in Prolog has several advantages relative to programs written in conventional programming languages: notably, conciseness and clarity. The program presented here implements several normalization algorithms and is suitable for the interactive design of small database applications and as a teaching aid.
Review: Implants (1994)

An implantable sustained release device has been developed to treat chronic disorders of the eye. The device, consisting of a central core of drug encased in layers of permeable and impermeable polymers, can be implanted subconjunctivally or intravitreally. This technique was used to develop a ganciclovir device which, when implanted into the vitreous, maintains therapeutic vitreous levels of drug for 8 months. Initial studies in patients with cytomegalovirus (CMV) retinitis indicate that this treatment may offer better control of the disease and fewer side effects than existing therapies. Cyclosporine A devices were prepared for the treatment of uveitis. Early data suggests that these devices maintain therapeutic levels in the vitreous for approximately 3 years. Work on efficacy and toxicity is continuing. Although clinical applications of these devices are likely to be restricted to diseases requiring chronic drug therapy, they can be used to investigate optimal delivery rates. Subconjunctivally implanted devices releasing 5-FU for 12 days maintained filters in cynomolgus monkeys for 3 months. Similar devices maintained low intraocular pressure in 75% of high risk filter patients.
통합 장기등이식법의 핵심쟁점과 기본방향 (2018)

이 논문은 현재 장기이식법, 조직이식법, 제대혈법 및 조혈모세포이식법안으로 난립하고 있는 소위 이식4법의 통합법으로서의 소위 통합 장기등이식법의 입법방향을 제시하고 있다.
그 동안 국회에서는 다음과 같은 사항들에 대하여 시정할 것을 줄기차게 요구해 왔다. 즉, 2014년 결산에서는 장기와 인체조직의 구득활동을 연계하여 효율적으로 수행할 수 있는 방법을 마련하고 중장기적으로 통합관리체계를 구축할 것, 2015년 국정감사에서는 장기기증 활성화를 위한 홍보강화 및 홍보예산 집행을 장기이식센터로 일원화하고 장기적으로 장기와 인체조직의 통합관리체계를 구축할 것, 2015년 결산에서는 보건복지부는 장기와 인체조직의 기증관리에 관한 통합계획을 구체적 일정을 마련하여 추진할 것, 2016년 국정감사에서는 장기와 인체조직의 기증절차가 이원화되어 있어 기증자의 불편과 예산집행의 비효율 문제가 발생하고 있으므로 관련법 및 기관을 통합하여 기증절차를 통합적으로 구축할 것이 국회로부터 시정요구된 핵심적 사항이다.
통합 장기등이식법에 관한 입법의 기본방향으로서 장기이식법으로 중심으로 한 통합, 심장사와 함께 장기이식과 무관한 뇌사를 판정하게 함으로써 사망판정의 이원화, 뇌사판정위원회의 폐지, 미성년자의 장기기증의 금지 및 한국장기조직기증원(KODA)에 의한 장기, 조직, 세포라는 장기등의 구득기관의 통합을 제안하고 있다.
Percutaneous Cement Injection into a Created Cavity for the Treatment of Vertebral Body Fracture (2006)

The Cavity Creation System is a safe, cost-effective treatment of VBF resulting in good/excellent pain relief and an improved quality of life.
Hepatic Contrast Agents for Computed Tomography (1981)

We used a stepwise approach to identify, design, synthesize, and test new high atomic number particulate contrast agents that would be especially well suited for use with computed tomography (CT). Our goal was to produce extremely radiopaque compounds with highly selective biodistribution to the normal liver. In this way, dose requirements could be lessened and toxicity minimized. Suspensions of cerium, gadolinium, and dysprosium oxide particles and silver iodide colloid were tested and compared with standard agents. All four experimental agents were selectively concentrated in the reticuloendothelial systems of rats and rabbits. These compounds produced greater and longer opacification of normal livers and larger liver-to-tumor differences in rabbits with hepatic tumors than did equivalent amounts of standard, iodinated agents. Lesions as small as 5 mm were visible with CT. These experimental materials have favorable characteristics as hepatic contrast agents, but their toxicity and long term retention may limit clinical use.
Characteristics of streaming media stored on the Web (2005)

Despite the growth in multimedia, there have been few studies that focus on characterizing streaming audio and video stored on the Web. This investigation used a customized Web crawler to traverse 17 million Web pages from diverse geographic locations and identify nearly 30,000 streaming audio and video clips available for analysis. Using custom-built extraction tools, these streaming media objects were analyzed to determine attributes such as media type, encoding format, playout duration, bitrate, resolution, and codec. The streaming media content encountered is dominated by proprietary audio and video formats with the top four commercial products being RealPlayer, Windows Media Player, MP3 and QuickTime. The distribution of the stored playout durations of streaming audio and video clips are long-tailed. More than half of the streaming media clips encountered are video, encoded primarily for broadband connections and at resolutions considerably smaller than the resolutions of typical monitors.
Direct Determination of Peracetic Acid, Hydrogen Peroxide, and Acetic Acid in Disinfectant Solutions by Far-Ultraviolet Absorption Spectroscopy (2005)

In this paper we propose a rapid and highly selective far-ultraviolet (FUV) spectroscopic method for the simultaneous determination of peracetic acid (PAA), hydrogen peroxide, and acetic acid (AA). For this purpose we developed a novel FUV spectrometer that enables us to measure the spectra down to 180 nm. Direct determination of PAA, H(2)O(2), and AA, the three main species in disinfectant solutions, was carried out by using their absorption bands in the 180-220-nm region. The proposed method does not require any reagents or catalysts, a calibration standard, and a complicated procedure for the analysis. The only preparation procedure requested is a dilution of H(2)O(2) with pure water to a concentration range lower than 0.2 wt % in the sample solutions. Usually, the required concentration range can be obtained by the 10 times volume dilution of the actual disinfectant solutions. As the measured sample does not leave any impurity for the disinfection, it can be reused completely by using a circulation system. The detection limit for PAA of the new FUV spectrometer was evaluated to be 0.002 wt %, and the dynamic ranges of the measured concentrations were from 0 to 0.05 wt %, from 0 to 0.2 wt %, and from 0 to 0.2 wt % for PAA, H(2)O(2), and AA, respectively. The response time for the simultaneous determination of the three species is 30 s, and the analysis is applicable even to the flowing samples. This method may become a novel approach for the continuous monitoring of PAA in disinfectant solutions on the process of sterilization.
Pedestrian intention recognition using Latent-dynamic Conditional Random Fields (2015)

We present a novel approach for pedestrian intention recognition for advanced video-based driver assistance systems using a Latent-dynamic Conditional Random Field model. The model integrates pedestrian dynamics and situational awareness using observations from a stereo-video system for pedestrian detection and human head pose estimation. The model is able to capture both intrinsic and extrinsic class dynamics. Evaluation of our method is performed on a public available dataset addressing scenarios of lateral approaching pedestrians that might cross the road, turn into the road or stop at the curbside. During experiments, we demonstrate that the proposed approach leads to better stability and class separation compared to state-of-the-art pedestrian intention recognition approaches.
The Absorption Spectra of Tetracyclones. IV<sup>1,2</sup> (1955)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Absorption Spectra of Tetracyclones. IV1,2Stephen B. Coan, Donald E. Trucker, and Ernest I. BeckerrCite this: J. Am. Chem. Soc. 1955, 77, 1, 60–66Publication Date (Print):January 1, 1955Publication History Published online1 May 2002Published inissue 1 January 1955https://pubs.acs.org/doi/10.1021/ja01606a018https://doi.org/10.1021/ja01606a018research-articleACS PublicationsRequest reuse permissionsArticle Views405Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Examples-Rules Guided Deep Neural Network for Makeup Recommendation (2017)

In this paper, we consider a fully automatic makeup recommendation system and propose a novel examples-rules guided deep neural network approach. The framework consists of three stages. First, makeup-related facial traits are classified into structured coding. Second, these facial traits are fed in- to examples-rules guided deep neural recommendation model which makes use of the pairwise of Before-After images and the makeup artist knowledge jointly. Finally, to visualize the recommended makeup style, an automatic makeup synthesis system is developed as well. To this end, a new Before-After facial makeup database is collected and labeled manually, and the knowledge of makeup artist is modeled by knowledge base system. The performance of this framework is evaluated through extensive experimental analyses. The experiments validate the automatic facial traits classification, the recommendation effectiveness in statistical and perceptual ways and the makeup synthesis accuracy which outperforms the state of the art methods by large margin. It is also worthy to note that the proposed framework is a pioneering fully automatic makeup recommendation systems to our best knowledge.
Anisotropic grain noise in eddy current inspection of noncubic polycrystalline metals (1998)

This letter discusses the role electrical anisotropy plays in the structural integrity assessment of polycrystalline titanium alloys from the standpoint of fatigue crack detection and the related issue of microstructural noise. In eddy current inspection of noncubic crystallographic classes of polycrystalline metals the electric anisotropy of individual grains produces an inherent microstructural variation or noise that is very similar to the well-known acoustic noise produced by the elastic anisotropy of both cubic and noncubic materials in ultrasonic characterization. The presented results demonstrate that although the electrical grain noise is clearly detrimental in eddy current nondestructive testing for small flaws, it can be also exploited for characterization of the microstructure in noncubic polycrystalline materials such as titanium alloys in the same way acoustic grain noise is used for ultrasonic characterization of the microstructure in different materials.
On ferrotoroidics and electrotoroidic, magnetotoroidic and piezotoroidic effects* (2001)

Abstract Some historical aspects of the discovery of the "axio-polar" (time-odd polar) vector, its appearance as an anapole moment in atomic nuclei and in the form of a spontaneous toroidal moment in "ferrotoroidic" crystals and domains are discussed. The related linear and bilinear "electrotoroidic" and "magnetotoroidic" effects, as well as the "piezotoroidic" and linear "toroido-optic effect" are postulated. Keywords: toroidal momentferrotoroidic domainsmagnetoelectricelectrotoroidicmagnetotoroidicpiezotoroidic
Error handling in the RavenClaw dialog management framework (2005)

We describe the error handling architectture underlying the RavenClaw dialog management framework. The architecture provides a robust basis for current and future research in error detection and recovery. Several objectives were pursued in its development: task-independence, ease-ofuse, adaptability and scalability. We describe the key aspects of architectural design which confer these properties, and discuss the deployment of this architectture in a number of spoken dialog systems spanning several domains and interaction types. Finally, we outline current research projects supported by this architecture.
Mask Defect Inspection Method by Database Comparison with 0.25–0.35 µ m Sensitivity (1994)

Photomasks used in the fabrication of ultra-LSI (ULSI) circuits must be inspected for defects. For 256 Mbit dynamic random access read write memory (DRAM), it is necessary to inspect defects as small as 0.15 µ m. Moreover, inspection of defects of phase-shift masks is becoming an important task of an inspection system. This paper describes an automated mask inspection system (MC-100) based on die-to-database comparison, and a defect inspection method with 0.15 µ m sensitivity for edge and pindot defects. System configuration and the defect inspection method are discussed in detail, including the difficulties of defect detection in an attenuated phase-shift mask.
Inclination of Baermann funnel wall and efficiency of nematode extraction. (1987)

ベルマン漏斗法の漏斗斜面角度と線虫分離効率(サツマイモネコブセンチュウ2期幼虫)との関係を試験した。ガラス漏斗斜面に夾雑物(微細土粒等)のない清浄な条件では斜面角度が増すにしたがい,分離効率は指数的に増加した。しかし,斜面上に微細土粒を沈着土させた条件では,60°よりゆるい斜面角度の分離効率が著しく高まったのに対し,それより急角度では却って低くなり,60°をピークとする1山型の分離効率曲線がえられた。線虫の和紙フィルター(1枚)の通過率は供試土壌の種類による大きく異なることが示唆された。
Gold, an alternative to platinum group metals in automobile catalytic converters (2011)

Catalytic convertors based on the use of platinum, palladium and rhodium play a major role in the cleaning of automobile emissions. Gold, when dispersed as nano-sized particles, has demonstrated significant activity in the conversion of toxic components, including carbon monoxide, unburnt hydrocarbons and nitrogen oxides, in engine emissions and some advantages over the platinum group metals. Some research outcomes on the application of nano-sized gold for the conversion of these components are reviewed. Several key issues in relation to its performance and applicability in catalytic convertors such as low-temperature activity and thermal stability and the possibilities of substituting platinum group metals for automobile emission control with gold are discussed.
ON BODY CONCEALED WEAPON DETECTION USING A PHASED ANTENNA ARRAY (2012)

The detection and identification of metal items and, in particular weapons, of linear size 10 cm, concealed upon the human body, is demonstrated as being entirely feasible by using a phased array of suitably ultra wide band transceivers. The complex natural resonances and especially the fundamental resonance, are excited by ultra wide band, stepped frequency continuous wave illumination of the target, using a phased array of antennae to focus the radiation. Broadband illumination of the target with microwave radiation of suitable frequency range (Typically 0.3-3 GHz for handgun sized objects) excites low order complex natural resonances and the late time response of the concealed item can be spatially located using phased array imaging techniques. Further processing of the late time response enables classification of the concealed object, based on the complex natural resonant frequencies of the object, so that threat items such as handguns and knives can be differentiated from benign items such as mobile phone handsets and cameras.
Enhanced Gas Sensing by Individual SnO<sub>2</sub> Nanowires and Nanobelts Functionalized with Pd Catalyst Particles (2005)

The sensing ability of individual SnO(2) nanowires and nanobelts configured as gas sensors was measured before and after functionalization with Pd catalyst particles. In situ deposition of Pd in the same reaction chamber in which the sensing measurements were carried out ensured that the observed modification in behavior was due to the Pd functionalization rather than the variation in properties from one nanowire to another. Changes in the conductance in the early stages of metal deposition (i.e., before metal percolation) indicated that the Pd nanoparticles on the nanowire surface created Schottky barrier-type junctions resulting in the formation of electron depletion regions within the nanowire, constricting the effective conduction channel and reducing the conductance. Pd-functionalized nanostructures exhibited a dramatic improvement in sensitivity toward oxygen and hydrogen due to the enhanced catalytic dissociation of the molecular adsorbate on the Pd nanoparticle surfaces and the subsequent diffusion of the resultant atomic species to the oxide surface.
Skp is a periplasmic <i>Escherichia coli</i> protein requiring SecA and SecY for export (1991)

Skp of Escherichia coli (OmpH of Salmonella typhimurium) is a protein whose precise function has been obscured by its ubiquity in a wide range of subcellular fractions such as those containing DNA, ribosomes, and outer membranes. Combining in vitro and in vivo techniques we show that Skp is synthesized as a larger precursor that is processed upon translocation across the plasma membrane. Translocation is dependent on the H(+)-gradient, ATP, SecA, and SecY. Upon cellular subfractionation (avoiding non-specific electrostatic interactions) Skp partitions with beta-lactamase into the fraction of soluble, periplasmic proteins. In the context of the export factor properties of Skp previously demonstrated in vitro it is conceivable that this protein is involved in the later steps of protein translocation across the plasma membrane and/or sorting to the outer membrane.