gebhart/patrepeval huggingface dataset:
Electromagnetically Induced Transparency (EIT) Amplitude Noise Spectroscopy (2017)

Intensity noise cross-correlation of the polarization eigenstates of light emerging from an atomic vapor cell in the Hanle configuration allows one to perform high resolution spectroscopy with free- running semiconductor lasers. Such an approach has shown promise as an inexpensive, simpler approach to magnetometry and timekeeping, and as a probe of dynamics of atomic coherence in warm vapor cells. We report that varying the post-cell polarization state basis yields intensity noise spectra which more completely probe the prepared atomic state. We advance and test the hypothesis that the observed intensity noise can be explained in terms of an underlying stochastic process in lightfield amplitudes themselves. Understanding this stochastic process in the light field amplitudes themselves provides a new test of the simple atomic quantum optics model of EIT noise.
Constrained Maximum Likelihood Estimation for Model Calibration Using Summary-Level Information From External Big Data Sources (2016)

Information from various public and private data sources of extremely large sample sizes are now increasingly available for research purposes. Statistical methods are needed for utilizing information from such big data sources while analyzing data from individual studies that may collect more detailed information required for addressing specific hypotheses of interest. In this article, we consider the problem of building regression models based on individual-level data from an "internal" study while utilizing summary-level information, such as information on parameters for reduced models, from an "external" big data source. We identify a set of very general constraints that link internal and external models. These constraints are used to develop a framework for semiparametric maximum likelihood inference that allows the distribution of covariates to be estimated using either the internal sample or an external reference sample. We develop extensions for handling complex stratified sampling designs, such as case-control sampling, for the internal study. Asymptotic theory and variance estimators are developed for each case. We use simulation studies and a real data application to assess the performance of the proposed methods in contrast to the generalized regression (GR) calibration methodology that is popular in the sample survey literature.
Tribological properties of PTFE‐filled thermoplastic polyimide at high load, velocity, and temperature (2009)

Abstract The effect of 20 wt% polytetrafluoroethylene (PTFE) fillers on the friction and wear properties of thermoplastic polyimides (TP) are investigated, under dry sliding in line contact against steel under 50 to 200 N, 0.3 to 1.2 m/s, and 60 to 260°C. Besides the lubricating mechanisms of PTFE based on mechanical shear, the thermal and tribophysical interactions in the sliding interface are considered in this research by using thermoanalytical measurements, Raman spectroscopy, and calculating the maximum polymer sliding temperature T *. The effect of hydrolysis of the TP bulk material, causing high friction at 100 to 140°C, is covered by PTFE. A transition at pv ‐values 2.2 MPa m/s ( T * = 120°C) is due to thermally controlled sliding of PTFE, while a transition at pv ‐values 3.2 MPa m/s ( T * = 180°C) remains controlled by degradation of the TP bulk material into monomer fractions. The reduced coefficient of friction in the presence of PTFE leads to smaller degradation and orientation of the molecular back‐bone and side‐chains within the TP structure. The formation of a homogeneously mixed transfer film is only observed at 180 to 260°C. The PTFE forms a fibrillar structure during wear at high sliding velocities, while they wear as separate particles at high normal loads. POLYM. COMPOS., 2009. © 2009 Society of Plastics Engineers
Signs and Symptoms in the Presentation of Primary Infantile Glaucoma (1986)

Delayed initiation of proper therapy for infants with primary infantile glaucoma results in an unnecessarily poor outcome. In an effort to understand why some infants and children had more advanced disease than others, researchers reviewed the records of 24 consecutive infants and children with this problem. The presenting signs and symptoms were studied in particular. As noted by the parents, only 32% had the full classic symptom complex of epiphora and photophobia/blepharospasm. Twenty-one percent of infants and children presented with parents having noted signs of infantile glaucoma without ever noting symptoms. More than 90% of infants and children had signs of glaucoma at their initial presentation to a physician. Signs of glaucoma are apparently more difficult to appreciate in bilateral cases. In each of the three cases in which physicians repeatedly failed to make the diagnosis or refer the patient to an ophthalmologist bilateral disease was present. Recognition of the signs and symptoms of primary infantile glaucoma will allow physicians to refer infants and children at a time when good vision may be maintained in the majority of cases.
ChemInform Abstract: ULTRA‐SHORT‐ACTING β‐ADRENERGIC RECEPTOR BLOCKING AGENTS. 2. (ARYLOXY)PROPANOLAMINES CONTAINING ESTERS ON THE ARYL FUNCTION (1983)

Abstract Ausgehend von den Phenolen (I) erhält man über die Epoxide (II) die Aryloxypropanolamine (III), von denen das Derivat (IV) als β‐Blocker mit Propranolol (V) verglichen wird.
Poised for next-century politics? (1999)

From management hierarchies, to leveraging "who you know," to shared governance, organizational politics have changed over the years. Best bets for the future: Be a good leader, don't get hung up on titles, and value your employees.
Benchmarking Membrane Protein Detergent Stability for Improving Throughput of High-Resolution X-ray Structures (2011)

Obtaining well-ordered crystals is a major hurdle to X-ray structure determination of membrane proteins. To facilitate crystal optimization, we investigated the detergent stability of 24 eukaryotic and prokaryotic membrane proteins, predominantly transporters, using a fluorescent-based unfolding assay. We have benchmarked the stability required for crystallization in small micelle detergents, as they are statistically more likely to lead to high-resolution structures. Using this information, we have been able to obtain well-diffracting crystals for a number of sodium and proton-dependent transporters. By including in the analysis seven membrane proteins for which structures are already known, AmtB, GlpG, Mhp1, GlpT, EmrD, NhaA, and LacY, it was further possible to demonstrate an overall trend between protein stability and structural resolution. We suggest that by monitoring membrane protein stability with reference to the benchmarks described here, greater efforts can be placed on constructs and conditions more likely to yield high-resolution structures.
Micrometer-sized nozzles and skimmers for the production of supersonic He atom beams (1997)

Micrometer-sized nozzles and skimmers made from drawn glass tubes are described and tested for the production of highly monoenergetic He atom beams. Glass nozzles with diameters between 1 μm and 4 μm when operated at He source stagnation pressures of up to 1000 atm provide intense beams with measured speed ratios of S=50–100, in good agreement with the predicted behavior scaled from nozzles with larger openings. Miniature glass skimmers with diameters as small as 3 μm were also successfully tested with conventional 10 μm diameter nozzles. These miniature nozzle-beam sources can be used to greatly reduce the size of present-day He-atom surface-scattering time-of-flight spectrometers and to reduce the number of vacuum stages and the size of vacuum pumps. They also open up new experimental possibilities as illustrated by measurements of the spatial profiles of seeded nozzle beams.
High Performance LiNi<sub>0.5</sub>Mn<sub>1.5</sub>O<sub>4</sub> Spinel Li-Ion Battery Cathode Development (2013)

Due to its high theoretical capacity (147 mAh/g), high operating voltage (~4.7V vs. Li/Li + of Ni 2+ /Ni 4+ couple), and inherent cycle stability (Mn 4+ state, no Jahn-Teller distortion of Mn 3+ ), LiNi 0.5 Mn 1.5 O 4 (LNMO) spinel is a promising cathode active material for high energy density lithium ion batteries [1, 2, 3] that can potentially be used in a wide range of applications including consumer electronics, electric vehicles, military and space. However, some performance issues of LNMO need to be addressed before its practical commercialization. These include extended cycle life, high rate capability, and cycle stability at elevated temperatures (e.g. 55°C).Here we report efforts at ADA Technologies, Inc. to optimize LiNi 0.5 Mn 1.5 O 4 (LNMO) spinel performance via material and operational approaches. In addition to improved stability with the electrolyte [4], oxide coatings applied via atomic layer deposition (ALD) technique are used to address cycle stability of LNMO at high temperatures.
Customizing Your Phone (2011)

Windows Phone 7 features an interface that's pretty unique among smartphones, shunning the rows of many icons that are well known to iOS and Android users (and users of Windows Mobile and Pocket PC devices) for large live tiles and a sleek, somewhat sparse, modern design. There are a number of customizations you can make to your phone that can help make it your own, and we'll discuss some of those. Others, like changing your wallpaper on the Lock screen or changing the picture displayed on the Pictures live tile, will be discussed in future chapters.
Performance evaluation of Intel® transactional synchronization extensions for high-performance computing (2013)

Intel has recently introduced Intel® Transactional Synchronization Extensions (Intel® TSX) in the Intel 4th Generation Core™ Processors. With Intel TSX, a processor can dynamically determine whether threads need to serialize through lock-protected critical sections. In this paper, we evaluate the first hardware implementation of Intel TSX using a set of high-performance computing (HPC) workloads, and demonstrate that applying Intel TSX to these workloads can provide significant performance improvements. On a set of real-world HPC workloads, applying Intel TSX provides an average speedup of 1.41x. When applied to a parallel user-level TCP/IP stack, Intel TSX provides 1.31x average bandwidth improvement on network intensive applications. We also demonstrate the ease with which we were able to apply Intel TSX to the various workloads.
Dynamic IP-VPN architecture for cloud computing (2010)

In this paper we propose our new architecture of the Dynamic IP-VPN which is used for cloud computing services. There are some kinds of use cases of the cloud service. One is public cloud. Public cloud is on the Internet and can be accessed by any users, so the enterprise users adopt a passive attitude to using it for business use. Another is private cloud. Private cloud is separated from the Internet. Only the closed users can access it though the leased line. Though the security problem can be solved, it is a difficult point that the cost is high. The new third category is virtual private cloud which is connected to the users via IP-VPN on the Internet. However we are confronted with some problems to connect clouds to IP-VPN. Cloud computing environment are so flexible that a virtual machine might appear and disappear in a short term and migrate to other data center depending on the load condition. Conventional IP-VPN is not suitable for this situation. Therefore we discuss new requirements and architecture for cloud computing environment.
<i>In vivo</i> Safety and Antitumor Efficacy of Bifunctional Small Hairpin RNAs Specific for the Human Stathmin 1 Oncoprotein (2011)

Bifunctional small hairpin RNAs (bi-shRNAs) are functional miRNA/siRNA composites that are optimized for posttranscriptional gene silencing through concurrent mRNA cleavage-dependent and -independent mechanisms (Rao et al., 2010 ). We have generated a novel bi-shRNA using the miR30 scaffold that is highly effective for knockdown of human stathmin (STMN1) mRNA. STMN1 overexpression well documented in human solid cancers correlates with their poor prognosis. Transfection with the bi-shSTMN1-encoding expression plasmid (pbi-shSTMN1) markedly reduced CCL-247 human colorectal cancer and SK-Mel-28 melanoma cell growth in vitro (Rao et al., 2010 ). We now examine in vivo the antitumor efficacy of this RNA interference-based approach with human tumor xenografted athymic mice. A single intratumoral (IT) injection of pbi-shSTMN1 (8 μg) reduced CCL-247 tumor xenograft growth by 44% at 7 days when delivered as a 1,2-dioleoyl-3-trimethyl-ammoniopropane:cholesterol liposomal complex. Extended growth reductions (57% at day 15; p < 0.05) were achieved with three daily treatments of the same construct. STMN1 protein reduction was confirmed by immunoblot analysis. IT treatments with pbi-shSTMN1 similarly inhibited the growth of tumorgrafts derived from low-passage primary melanoma (≥70% reduction for 2 weeks) and abrogated osteosarcoma tumorgraft growth, with the mature bi-shRNA effector molecule detectable for up to 16 days after last injection. Antitumor efficacy was evident for up to 25 days posttreatment in the melanoma tumorgraft model. The maximum tolerated dose by IT injection of >92 μg (Human equivalent dose [HED] of >0.3 mg/kg) in CCL-247 tumor xenograft-bearing athymic mice was ∼10-fold higher than the extrapolated IC(50) of 9 μg (HED of 0.03 mg/kg). Healthy, immunocompetent rats were used as biorelevant models for systemic safety assessments. The observed maximum tolerated dose of <100 μg for intravenously injected pbi-shSTMN1 (mouse equivalent of <26.5 μg; HED of <0.09 mg/kg) confirmed systemic safety of the therapeutic dose, hence supporting early-phase assessments of clinical safety and preliminary efficacy.
Elasticity of marine sediments: Rock physics modeling (1999)

We offer an effective medium model for the elastic moduli of high‐porosity ocean‐bottom sediments. The elastic constants of the dry‐sediment frame depend on porosity, elastic moduli of the solid phase, and effective pressure. The model connects two end points in the elastic‐modulus‐porosity plane: the Hertz‐Mindlin modulus of a dense elastic sphere pack at critical porosity; and zero at 100% porosity. The elastic moduli of saturated sediment are calculated from those of the dry frame using Gassmann's equation. Unlike the suspension model, our model assigns non‐zero elastic constants to the dry‐sediment frame and can predict the shear‐wave velocity. Unlike various modifications of the travel‐time‐average equation, it is first‐principle‐based and contains only physical parameters. We justify this model by matching sonic data in shallow marine sediments and in an ODP well.
A Novel Glucose Sensor Based on Deflection of a Thin Membrane (2005)

A novel glucose sensor based on the deflection of a thin membrane is proposed in the article. The sensor consists of a glucose-sensitive hydrogel layer which exhibits swelling when immersed in a glucose-containing solution. A detailed overview of the fabrication procedure and preliminary experimental results for real-time glucose monitoring using our prototype devices will be presented.
A New Corona-and Heat-Resistant Cable Insulation Based on Etkylene Propylene Rubber (1963)

After a review of water-resistant insulations now in use for power cables, the properties of a new corona and heat-resistant rubber-like water-resistant cable insulation based on ethylene-propylene rubber (EPR) are compared with those of butyl-base rubber and cross-linked (vulcanized) polyethylene. It is concluded that the new insulation has a more attractive combination of properties than either butyl or cross-linked polyethylene and that it could be operated continuously at 90 C up to 28,000 volts in either wet or dry locations.
DiscLDA: Discriminative Learning for Dimensionality Reduction and Classification (2008)

Probabilistic topic models have become popular as methods for dimensionality reduction in collections of text documents or images. These models are usually treated as generative models and trained using maximum likelihood or Bayesian methods. In this paper, we discuss an alternative: a discriminative framework in which we assume that supervised side information is present, and in which we wish to take that side information into account in finding a reduced dimensionality representation. Specifically, we present DiscLDA, a discriminative variation on Latent Dirichlet Allocation (LDA) in which a class-dependent linear transformation is introduced on the topic mixture proportions. This parameter is estimated by maximizing the conditional likelihood. By using the transformed topic mixture proportions as a new representation of documents, we obtain a supervised dimensionality reduction algorithm that uncovers the latent structure in a document collection while preserving predictive power for the task of classification. We compare the predictive power of the latent structure of DiscLDA with unsupervised LDA on the 20 Newsgroups document classification task and show how our model can identify shared topics across classes as well as class-dependent topics. 1
RAGE-dependent potentiation of TRPV1 currents in sensory neurons exposed to high glucose (2018)

Diabetes mellitus is associated with sensory abnormalities, including exacerbated responses to painful (hyperalgesia) or non-painful (allodynia) stimuli. These abnormalities are symptoms of diabetic peripheral neuropathy (DPN), which is the most common complication that affects approximately 50% of diabetic patients. Yet, the underlying mechanisms linking hyperglycemia and symptoms of DPN remain poorly understood. The transient receptor potential vanilloid 1 (TRPV1) channel plays a central role in such sensory abnormalities and shows elevated expression levels in animal models of diabetes. Here, we investigated the function of TRPV1 channels in sensory neurons cultured from the dorsal root ganglion (DRG) of neonatal mice, under control (5mM) and high glucose (25mM) conditions. After maintaining DRG neurons in high glucose for 1 week, we observed a significant increase in capsaicin (CAP)-evoked currents and CAP-evoked depolarizations, independent of TRPV1 channel expression. These functional changes were largely dependent on the expression of the receptor for Advanced Glycation End-products (RAGE), calcium influx, cytoplasmic ROS accumulation, PKC, and Src kinase activity. Like cultured neurons from neonates, mature neurons from adult mice also displayed a similar potentiation of CAP-evoked currents in the high glucose condition. Taken together, our data demonstrate that under the diabetic condition, DRG neurons are directly affected by elevated levels of glucose, independent of vascular or glial signals, and dependent on RAGE expression. These early cellular and molecular changes to sensory neurons in vitro are potential mechanisms that might contribute to sensory abnormalities that can occur in the very early stages of diabetes.
Processing materials with lasers (1976)

How can we make an alloy to fit a specific materials requirement? The oldest method of alloy fabrication, casting, has two inherent limitations: Phases with high melting points are difficult to melt; and the cooling of the alloys from the melt is slow, so that alloy segregation and phase separation have time to occur. The other traditional method, powder metallurgy, has helped with the second of these problems: Allowing the homogeneous melt to be cooled in tiny droplets makes it possible at least to limit segregation to the scale of the resulting powder particles.
Modulated Ionomer Distribution in the Catalyst Layer of Polymer Electrolyte Membrane Fuel Cells for High Temperature Operation (2014)

Ionomer distribution is an important design parameter for high performance polymer electrolyte membrane fuel cells (PEMFCs); however, the nano-scale modulation of the ionomer morphology has not been intensively explored. Here, we propose a new route to modulate the ionomer distribution that features the introduction of poly(ethylene glycol) (PEG) to the cathode catalyst layer and the leaching the PEG phase from the catalyst layer using a water effluent during operation. The key concept in the approach is the expansion of the ionomer thin film through the PEG addition. We demonstrate that the modulated ionomer distribution increases the electrochemical active area and proton transport property, without loss in oxygen transport, at a fixed ionomer content. At a high temperature of 120 °C, the power performance at 0.6 V is increased by 1.73-fold with the modulated ionomer distribution as a result of 1.25-fold increase in the electrochemical active area and two-fold increase in the proton transport rate in the catalyst layer.
Generic scanned-probe microscope sensors by combined micromachining and electron-beam lithography (1998)

We present a novel method for the fabrication of generic scanned-probe microscope probes by performing multiple level direct-write electron-beam lithography on the apex of micromachined atomic force microscope tips. Pattern transfer is by conventional etching or liftoff in a wide range of materials. Lithographic resolution is 50 nm or better. The substrates support the use of automatic alignment and allow for the fabrication of 50 probes/in2. The integration of a force-sensing cantilever permits simple height regulation of the probes during operation. The technology is illustrated by the fabrication of thermocouple and near-field optical probes.
Effects of Different Forms of Dietary Hydrogenated Fats on Serum Lipoprotein Cholesterol Levels (1999)

Background Metabolic studies suggest that fatty acids containing at least one double bond in the trans configuration, which are found in hydrogenated fat, have a detrimental effect on serum lipoprotein cholesterol levels as compared with unsaturated fatty acids containing double bonds only in the cis configuration. We compared the effects of diets with a broad range of trans fatty acids on serum lipoprotein cholesterol levels.
Direct binding to integrins and loss of disulfide linkage in interleukin-1β (IL-1β) are involved in the agonistic action of IL-1β (2017)

There is a strong link between integrins and interleukin-1β (IL-1β), but the specifics of the role of integrins in IL-1β signaling are unclear. We describe that IL-1β specifically bound to integrins αvβ3 and α5β1. The E128K mutation in the IL1R-binding site enhanced integrin binding. We studied whether direct integrin binding is involved in IL-1β signaling. We compared sequences of IL-1β and IL-1 receptor antagonist (IL1RN), which is an IL-1β homologue but has no agonistic activity. Several surface-exposed Lys residues are present in IL-1β, but not in IL1RN. A disulfide linkage is present in IL1RN, but is not in IL-1β because of natural C117F mutation. Substitution of the Lys residues to Glu markedly reduced integrin binding of E128K IL-1β, suggesting that the Lys residues mediate integrin binding. The Lys mutations reduced, but did not completely abrogate, agonistic action of IL-1β. We studied whether the disulfide linkage plays a role in agonistic action of IL-1β. Reintroduction of the disulfide linkage by the F117C mutation did not affect agonistic activity of WT IL-1β, but effectively reduced the remaining agonistic activity of the Lys mutants. Also, deletion of the disulfide linkage in IL1RN by the C116F mutation did not make it agonistic. We propose that the direct binding to IL-1β to integrins is primarily important for agonistic IL-1β signaling, and that the disulfide linkage indirectly affects signaling by blocking conformational changes induced by weak integrin binding to the Lys mutants. The integrin-IL-1β interaction is a potential target for drug discovery.