gebhart/patrepeval huggingface dataset:
Differential expression of type I insulin‐like growth factor receptors in different stages of human T cells (1995)

Insulin-like growth factor I (IGF-I) has been implicated to play a regulatory role in T cell development and in T cell function. We investigated the expression of type I IGF receptors on human peripheral T cells related to the maturation and activation stage using the type I IGF receptor-specific monoclonal antibody alpha IR3. It appeared that 87% of the CD4+CD45RA+ cells and 66% of the CD8+CD45RA+ cells were alpha IR3+, whereas only 37% of the CD4+CD45R0+ cells and 38% of the CD8+CD45R0+ cells bound alpha IR3. We also found that the fraction of alpha IR3+ cells within in vivo or in vitro activated (HLA-DR+) T cells is markedly lower than in nonactivated (HLA-DR-) cells. In vitro phytohemagglutinin-activated T cells and CD4+CD45R0+ cells activated with recall antigens also contained less alpha IR3+ cells (1-6%) than nonactivated cells (30-54%).
Experimental Studies of Light-Induced Charge Transfer and Charge Redistribution in (X<sub>2</sub>-Bipyridine)Re<sup>I</sup>(CO)<sub>3</sub>Cl Complexes (2002)

Stark emission spectroscopy, transient DC photoconductivity (TDCP), and ground-state dipole moment measurements have been used to evaluate charge transfer (CT) within various (X(2)-bipyridine)Re(I)(CO)(3)Cl complexes following (3)MLCT excited-state formation. The Stark technique reports on vector differences between ground-state (mu(g)) and excited-state (mu(e)) dipole moments, while TDCP, when combined with independently obtained mu(g) information, reports on scalar differences. For systems featuring collinear, same-signed ground- and excited-state dipole moments, the scalar and vector differences are equivalent. However, for the low symmetry systems studied here, they are distinctly different. The vector difference yields the effective adiabatic one-electron-transfer distance (R(12)), while the combined vector and scalar data yield information about dipole rotation upon ground-state/excited-state interconversion. For the systems examined, charge transfer distances are substantially smaller than geometric electron-donor/electron-acceptor site separation distances. The measured distances are significantly affected by changes in acceptor ligand substituent composition. Electron-donating substituents decrease CT distances, while electron-withdrawing substituents increase CT distances, as do aromatic substituents that are capable of expanding the bipyridyl ligand (acceptor ligand) pi system. The Stark measurements additionally indicate that the CT vector and the transition dipole moment are significantly orthogonal, a consequence of strong polarization of the Re-Cl bond (orthogonal to the metal/acceptor-ligand plane) in the ground electronic state and relaxation of the polarization in the upper state. The ground-state Re-Cl bond polarization is sufficiently large that the overall ground-state scalar dipole moment exceeds the overall excited-state scalar dipole moment, despite transfer of an electron from the metal center to the diimine ligand. This finding provides an explanation for the otherwise puzzling negative solvatochromism exhibited in this family of compounds. Combining TDCP and Stark results, we find that the dipole moment can be rotated in some instances by more than 90 degrees upon (3)MLCT excited-state formation. The degree of rotation or reorientation can be modulated by changing the identity of the acceptor ligand substituents. Reorientational effects are smallest when the compounds feature aromatic substituents capable of spatially extending the pi system of the acceptor ligand.
Passage of uncharged dextrans from blood to lung lymph in awake sheep (1985)

To examine how molecular size alone influences the passage of macromolecules from the pulmonary microcirculation into lymph collected from the caudal mediastinal lymph node of the sheep, we infused polydisperse uncharged [3H]dextrans intravenously at a constant rate over a period of 7.5 h in nine awake sheep with lung lymph fistulas. Lymph and plasma were collected during hours 5.5-7.5 of the infusions, and the [3H]dextrans were separated by molecular sieve chromatography into fractions that ranged from 1.6 to 8.4 nm in effective molecular (Stokes-Einstein) radius. Lymph-to-plasma (L/P) ratios for [3H]dextrans were near 1.0 at 1.6-nm radius, decreased with increasing molecular size, and approached zero at radii above 5.0 nm. We confirmed that these L/P ratios represented steady-state values by extending the duration of the infusion to approximately 30 h in two of the nine sheep and finding that the L/P ratios remained unchanged. These results were consistent with molecular sieving through a homoporous membrane with cylindrical pores of 5.0-nm radius. We also found that the L/P ratio for albumin [0.76 +/- 0.13 (SE)] in five of the same sheep was much higher than that for the [3H]dextran fraction of the same effective molecular radius [0.11 +/- 0.02 (SE)]. These results suggest that the movement of macromolecules from the pulmonary microcirculation into pulmonary lymph collected from the caudal mediastinal node of the sheep is influenced by both molecular size and molecular charge and that, compared with uncharged dextrans, the steady-state passage of anionic endogenous proteins from plasma to lymph is enhanced.
《轩辕剑III外传——天之痕》前瞻 (2000)

盛产RPG大作的台湾大宇公司将在今年12月底正式发售人气值极旺的RPG大作《轩辕剑Ⅲ——云和山的彼端》的外传《轩辕剑Ⅲ外传——天之痕》，这无疑是眼光挑剔的玩家今年最大的福音(应该说是象我一样的吧，哈哈)。
Smartphone Fingerprinting Via Motion Sensors: Analyzing Feasiblity at Large-Scale and Studing Real Usage Patterns. (2016)

Advertisers are increasingly turning to fingerprinting techniques to track users across the web. As web browsing activity shifts to mobile platforms, traditional browser fingerprinting techniques become less effective; however, device fingerprinting using built-in sensors offers a new avenue for attack. We study the feasibility of using motion sensors to perform device fingerprinting at scale, and explore countermeasures that can be used to protect privacy. 
We perform a large-scale user study to demonstrate that motion sensor fingerprinting is effective with even 500 users. We also develop a model to estimate prediction accuracy for larger user populations; our model provides a conservative estimate of at least 12% classification accuracy with 100000 users. We then investigate the use of motion sensors on the web and find, distressingly, that many sites send motion sensor data to servers for storage and analysis, paving the way to potential fingerprinting. Finally, we consider the problem of developing fingerprinting countermeasures; we evaluate a previously proposed obfuscation technique and a newly developed quantization technique via a user study. We find that both techniques are able to drastically reduce fingerprinting accuracy without significantly impacting the utility of the sensors in web applications.
Embryonic Stem Cells and Gene Targeting (2000)

The development of gene targeting technology, the exchange of an endogenous allele of a target gene for a mutated copy via homologous recombination, and the application of this technique to murine embryonic stem cells has made it possible to alter the germ-line of mice in a predetermined way. Gene targeting has enabled researchers to generate mouse strains with defined mutations in their genome allowing the analysis of gene function in vivo. This review presents the essential tools and methodologies used for gene targeting that have been developed over the past decade. Special emphasis has been laid on the available embryonic stem cell lines and the importance of the genetic background. Also, the state-of-the art of gene targeting approaches in species other than mice will be discussed.
Characterization in vitro of the effect of spacer length on the activity of Escherichia coli RNA polymerase at the TAC promoter. (1985)

We describe the characterization in vitro of three hybrid trp-lacUV5 (TAC) promoters, which have perfect homology to the -10 and -35 Escherichia coli promoter consensus hexamer sequences, but which differ in the distance between the -10 and -35 regions. The three promoters, TAC16, TAC17, and TAC18 have spacings of 16, 17, and 18 base pairs, respectively. We have measured KB and k2, the constants that describe the formation of open complexes, on these three promoters. We have also measured their relative strengths on supercoiled plasmid DNA. Our results show that these are the strongest promoters that have been characterized in vitro so far and confirm the hypothesis that the consensus promoter sequence is "best." We find the TAC17 promoter (KBk2 = 8.4 X 10(7) M-1 s-1) to be stronger than either the TAC16 (KBk2 approximately 1.5 X 10(7) M-1 s-1) or TAC18 (KBk2 approximately 3.5 X 10(7) M-1 s-1) promoters, a result that is in agreement with other findings on the effect of spacer length. The choice of start point for transcription is affected by spacer length. Transcription from all the promoters was stimulated at moderate concentrations of salt (less than 150 mM) and persisted at high salt concentrations (300 mM).
Escherichia coli rpoC397 encodes a temperature-sensitive C-terminal frameshift in the beta' subunit of RNA polymerase that blocks growth of bacteriophage P2 (1996)

Escherichia coli 397c is temperature sensitive for growth at 43.5 degrees C and unable to plate bacteriophage P2 at 33 degrees C. The mutation conferring these phenotypes was mapped to the rpoC gene. RNA synthesis is temperature sensitive in the mutant strain, and the beta' subunit of RNA polymerase isolated from this strain exhibits increased electrophoretic mobility. DNA sequence analysis revealed that the mutation is a deletion of 16 bp, resulting in a frameshift that leads to truncation of the beta' subunit at the carboxy terminus.
M4CVD: Mobile Machine Learning Model for Monitoring Cardiovascular Disease (2015)

In this paper we present M4CVD: Mobile Machine Learning Model for Monitoring Cardiovascular Disease, a system designed specifically for mobile devices that facilitates monitoring of cardiovascular disease (CVD). The system uses wearable sensors to collect observable trends of vital signs contextualized with data from clinical databases. Instead of transferring the raw data directly to the health care professionals, the system performs analysis on the local device by feeding the hybrid of collected data to a support vector machine (SVM) to monitor features extracted from clinical databases and wearable sensors to classify a patient as “continued risk” or “no longer at risk” for CVD. As a work in progress we evaluate a proof-of-concept M4CVD using a synthetic clinical database of 200 patients. The results of our experiment show the system was successful in classifying a patient's CVD risk with an accuracy of 90.5%.
Suppression of humoral immune responses by synthetic C3a peptides. (1983)

Synthetic oligopeptides based on the COOH-terminal sequence of native human C3a were examined for the ability to suppress antigen-specific and polyclonal antibody responses. The synthetic peptides were found to qualitatively mimic the suppressive actions of human C3a, but proved to be less active on a molar basis. Comparison of the activity of the peptides with native C3a indicates that the most potent peptide is C3a 57-77 with C3a 65-77, C3a 70-77, C3a[Ala 71,72]70-77, and C3a 73-77 being less active, respectively. These results indicate that the region of the C3a molecule responsible for immunosuppression is located in the COOH region.
Cell therapy for ischemic heart disease. (2004)

Despite advances in pharmacological therapies, cardiovascular surgery, use of mechanical assist devices, and organ transplantation, more than 50% of the patients with clinically evident heart failure die within 5 years of the initial diagnosis. The use of cellular therapy offers a promising approach for both the prevention and treatment of heart failure. This review will discuss the current state of this emerging field and the prospects to introduce the method into clinical practice. Since functional restoration of the damaged heart presents a formidable challenge, developing strategies for the prevention of postinfarct heart failure remains of utmost priority. Recent research has provided evidence that several cell lines including adult or embryonic stem cells, skeletal myoblasts, fetal cardiomyocytes or fibroblasts may be useful in strategies that aim to both prevent and treat heart failure through establishment of new blood vessels supplying surviving heart muscle cells and replacement of damaged heart muscle cells themselves. It is therefore reasonable to anticipate that new strategies will be developed to optimize cell delivery, homing and survival in the failing myocardium improving myocardial recovery after acute or chronic deterioration.
Changes in use of hormone replacement therapy after the report from the Women's Health Initiative: cross sectional survey of users (2003)

In 2002 the Women's Health Initiative reported the results of a study on the effects of combined oestrogen plus progestogen on healthy postmenopausal women. They found increased rates of breast cancer, coronary heart disease, stroke, and venous thromboembolism and decreased rates of hip fracture and colorectal disease but no “global” benefit. They concluded that combined oestrogen and progestogen is not suitable for the prevention of chronic diseases.1 The subsequent extensive media coverage came at a time when the prevalence,2 3 duration,2 4 and use of hormone replacement therapy (HRT) for the prevention of chronic disease had been increasing.2 4 After the report, government regulatory authorities issued advice to health professionals and women, and guidelines relating to the postmenopausal use of hormone replacement therapy were updated.5 We examined changes in HRT use since the publication of the report.

Between January 2000 and November 2002, 3500 women were screened from 23 general practices in four New Zealand centres as part of the recruitment process for the …
Experimental Analysis on Carbon Residuum Transformed Epoxy Resin: Chicken Feather Fiber Hybrid Composite (2018)

In this research article, the mechanical analysis and microstructure investigation of chicken feather fiber with carbon residuum (CR) (obtained from crumb rubber) fused with epoxy resin hybrid composite has been done. The fibers surface was alkali treated with caustic soda (sodium hydroxide) to improve the interfacial bonding with matrix and reinforcement. Herein, the composites were fabricated using the hand lay‐up technique. Chicken feathers in form of reinforcing fibers were taken in various weight percentages of 1, 3, 5, and 7. Various mechanical tests were performed in accordance with the ASTM standards, and it was perceived that the 5 weight percentage of chicken feathers recorded the optimum impact test results. Finally, the hybrid composites were fabricated with this weight percentage of feathers and varying weight percentages (0.5, 1, 1.5, 2, and 2.5) of CR. Mechanical testing was then conducted on these hybrid composites and determined that the tensile strength, flexural strength and impact strength showed a substantial enhancement. The justification of this enhancement was provided through the microstructural tests that includes the scanning electron microscopy and X‐ray diffraction analysis. Best results were forecasted for 5 wt% chicken feather and 1 wt% of CR hybrid composites amongst various combinations tried. Thus, noteworthy improvement in case of hybrid composite was seen as compared with neat epoxy. POLYM. COMPOS., 40:2690–2699, 2019. © 2018 Society of Plastics Engineers
Suppression mechanism of transverse-mode spurious responses in SAW resonators on a SiO<inf>2</inf>/Al/LiNbO<inf>3</inf> structure (2011)

The transverse-mode spurious responses could be suppressed successfully by the selectively SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> removal at the dummy region. This paper discusses the suppression mechanism of the transverse-mode spurious responses by the selectively SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> removal technique. The SAW field distribution was analyzed for the SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> /Al/LiNbO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> structure. The field analysis indicated that the selectively SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> removalenhances the SAW reflection coefficient at the boundary between the interdigital and the dummy electrode regions. When the SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> thickness is large, full SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> removal from the dummy electrode region creates another transverse mode resonance. The laser probe observation revealed that it is due to the hybrid mode caused by the coupling of the SH SAW with the Rayleigh SAW at the lateral boundaries. It was also shown that the response can be suppressed by the partial SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> removal from the dummy electrode region. This might be explained by the weakened mutual coupling between the SH and Rayleigh SAWs at the lateral boundaries. This weakening is caused by the reduction of the SAW velocity difference between the dummy electrode and IDT regions.
Condensed Multiwalled Carbon Nanotubes as Super Fibers (2006)

The ultra-low intershell shear strength in carbon nanotubes (CNTs) has been the primary obstacle to applications of CNTs as mechanical reinforcements. In this paper we propose a new CNT-system composed of comprising of coaxial cylindrical shells of sp2-bonded carbons with condensed intershell spacings. Our atomistic calculations show that such condensed multiwalled carbon nanotubes (CMWNTs) can greatly enhance intershell shear strengths by several orders, and can simultaneously generate higher tensile strengths and moduli respectively than those of ordinary CNTs. It has further shown that CMWNTs can maintain thermally stable up to 2,000 K. By taking advantage of the primary enhancement mechanism of CMWNTs, a method of producing CMWNTs is therefore proposed tentatively. It is believed that CMWNTs featured with those properties can be taken as excellent candidates of super fibers for creating space elevators.
A gripper based on a compliant bitable mechanism for gripping and active release of objects (2016)

A gripper with an embedded compliant bistable mechanism for gripping and autonomous release of objects is developed. Due to adhesion forces, objects might stick to the end-effector of a gripper upon release, where a shaking operation is necessary to release the objects. A bar adjacent to the shuttle mass of the bistable mechanism may achieve autonomous release of objects adhered to the end-effectors. Gripping and autonomous release of objects are accomplished when the bistable mechanism moves backward and forward, respectively. With the embedded bistable mechanism, the gripper requires no power input during gripping of objects. The compliant structure of the gripper renders no backlash, friction and wear for its operation.
A method of determination of the rate of molecular dissociation in solution. Parts I and II.—The rate of dissociation of benzoyl peroxide and 2 : 2′-azo-bis(isobutyronitrile) in various solvents (1951)

The first page of this article is displayed as the abstract.
The Histone Acetyltransferase, hGCN5, Interacts with and Acetylates the HIV Transactivator, Tat (2001)

Factor acetyltransferase activity associated with several histone acetyltransferases plays a key role in the control of transcription. Here we report that hGCN5, a well known histone acetyltransferase, specifically interacts with and acetylates the human immunodeficiency virus type 1 (HIV-1) transactivator protein, Tat. The interaction between Tat and hGCN5 is direct and involves the acetyltransferase and the bromodomain regions of hGCN5, as well as a limited region of Tat encompassing the cysteine-rich domain of the protein. Tat lysines 50 and 51, target of acetylation by p300/CBP, were also found to be acetylated by hGCN5. The acetylation of these two lysines by p300/CBP has been recently shown to stimulate Tat transcriptional activity and accordingly, we have found that hGCN5 can considerably enhance Tat-dependent transcription of the HIV-1 long terminal repeat. These data highlight the importance of the acetylation of lysines 50 and 51 in the function of Tat, since different histone acetyltransferases involved in distinct signaling pathways, GCN5 and p300/CBP, converge to acetylate Tat on the same site.
Molten ionic oxides for CO<sub>2</sub> capture at medium to high temperatures (2019)

Molten ionic oxides based on sodium borate and mixed alkali-metal borates show remarkably fast sorption kinetics and intrinsic regenerability as <italic>liquid</italic> absorbents for CO<sub>2</sub> capture at medium to high temperatures
Immunogold staining: adaptation of a cell-labeling system for analysis of human leukocyte subsets. (1984)

We have assessed the Immunogold Cell-Labeling System (IGS) for potential use in the clinical laboratory. In this technique, cell suspensions incubated with monoclonal mouse antibodies are reacted with anti-mouse antibodies labeled with colloidal gold. Surface marker cells, bearing dark blue-black granules, are easily distinguished by light microscopy. The percentages of T cells, T cell subsets, B cells, monocytes, or granulocytes identified by IGS corresponds with numbers obtained by flow cytometry analysis or immunofluorescence studies. Results by IGS and flow cytometry were similar for samples from patients with aberrant lymphocyte populations (e.g., leukemias) or from transplant recipients. IGS may thus be a useful diagnostic technique for studying neoplasias or other immunologically mediated disorders. This technique can also be used to characterize the surface phenotype of leukemic cell lines. The sensitivity and accuracy of IGS can be evaluated by measurements of different cell lines mixed in predetermined ratios.
Plasma IP-10, apoptotic and angiogenic factors associated with fatal cerebral malaria in India (2008)

The results suggest that plasma levels of IP-10, sTNF-R2 and sFas may be potential biomarkers of CM severity and mortality. VEGF was found to be protective against CM associated mortality and may be considered for adjunctive therapy to improve the treatment outcome in CM patients.
Promising particle-based vaccines in cancer therapy (2008)

Immunotherapy and preventative cancer vaccines offer the hope of controlling cancer in humans with few of the undesirable side effects associated with current chemotherapy-based methods. Particulate vaccines are effectively taken up by dendritic cells, inducing both T-cell and antibody responses. Virus-like particles (VLPs) have shown preventive efficacy against cervical cancer. Herein we review a range of leading particle-based vaccine approaches: VLPs, immunostimulating complexes, liposomes, synthetic nanoparticles and microparticles (both biocompatible and biodegradable, such as polylactide-co-glycolides and poly[D,L-lactic-co-glycolic] acid). Immune efficacy, regulatory and safety issues, as well the application of immunotherapeutics to immunosuppressed patients with high levels of Tregs are also discussed. We argue that developmental issues (cost and intellectual property lifespan) and the lack of reliable preclinical animal models, rather than the lack of innovative vaccine approaches, currently present a major obstacle to rapid and effective vaccine development.