gebhart/patrepeval huggingface dataset:
Evaluating Concurrent Executions of Multiple Function-as-a-Service Runtimes with MicroVM (2020)

Serverless computing and public Function-as-a-Service (FaaS) systems are gaining significant attention because they help easily build a highly available system. With recent advances in micro virtual machines (microVM), the internal architecture of FaaS systems substantially changes. This paper focuses on a thorough investigation of the recent improvement in public FaaS systems concerning numerous concurrent executions. The adoption of microVM has changed the nature of FaaS, especially for runtime reservations. As a result, the performance degradation has decreased significantly compared to the previous generation FaaS, as shown in the experiment.
K-ras activation in neoplasms of the human female reproductive tract. (1990)

The role of cellular oncogenes in the development of epithelial tumors of the human female reproductive tract has not previously been extensively studied. DNAs isolated from ten human uterine, 13 ovarian, and four cervical neoplasms and from three cell lines derived from endometrial adenocarcinoma were investigated by dot blot hybridization after polymerase chain reaction amplification of ras gene sequences and in some cases by NIH 3T3 transfection. Transforming activity was found in two of nine endometrial adenocarcinomas, but none of seven ovarian carcinomas and none of four cervical carcinomas showed transforming activity. K-ras sequences with a GGT----GAT mutation in codon 12 were demonstrated in both transformants derived from endometrial carcinoma. K-ras codon 12 mutations were similarly detected in six of 13 endometrial carcinomas (one GAT and GCT, one GTT and GCT, two GAT, two GTT) and two of 13 ovarian tumors (GAT and GCT, GAT), both mucinous adenocarcinomas. Point mutation of K-ras in codon 12 is thus comparably frequent in uterine endometrial carcinomas and in colorectal carcinomas and may have similar significance as an event that contributes to progression of these tumors. Cervical carcinomas and ovarian tumors in general, with the possible exception of mucinous adenocarcinoma of the ovary, do not appear to have this characteristic.
Content Distribution Networks: An Engineering Approach (2001)

From the Publisher:
The exponential growth of Internet traffic has created a huge demand for techniques that improve the speed and efficiency of data delivery. One of the most important emerging approaches in this area is the use of a content distribution network (CDN), which involves employing several distributed sites to improve the scalability and responsiveness of applications. Written for network operators, ISPs, network architects, researchers, and advanced computer science students alike, here is a much-needed comprehensive overview of the fundamentals of a content distribution network. It describes the components that make up a CDN, delineates the different technologies that can be used within the network, and illustrates how several Web-based applications can be accelerated using a CDN. Both an under-the-hood look at how CDNs work and a guide to practical applications of CDN technologies, Content Distribution Networks: An Engineering Approach is a must-have reference for anyone who operates a Web site, manages an intranet, or needs to master this rapidly emerging, powerful new technology.
Characteristics of electrically driven two-dimensional photonic crystal lasers (2005)

We demonstrate room-temperature low-threshold-current lasing action from electrically driven wavelength-scale high-quality photonic crystal lasers having large spontaneous emission factors by solving the theoretical and technical constraints laid upon by the additional requirement of the current injection. The ultrasmall cavity is electrically pulse pumped through a submicron-size semiconductor "wire" at the center of the mode with minimal degradation of the quality factor. In addition, to better utilize the low mobility of the hole, we employ a doping structure that is inverted from the conventional semiconductors. Rich lasing actions and their various characteristics are experimentally measured in the single-cell and three-cell photonic crystal cavities. Several relevant measurements are compared with three-dimensional finite-difference time-domain computations based on the actual fabricated structural parameters. The electrically driven photonic crystal laser, which is a small step toward a "practical" form of the single photon source, represents a meaningful achievement in the field of photonic crystal devices and photonic integrated circuits as well as of great interest to the quantum electrodynamics and quantum information communities.
[Excerpts from the clinical-pharmacologic and clinical studies of Grandaxin]. (1993)

The authors give a selection from the clinical-pharmacological and clinical studies of Grandaxin (tofizopam), an original Hungarian compound registered in 1976. Tofizopam, a 2,3-benzodiazepine derivative, differs from "classical" 1,4-benzodiazepines not only in chemical structure, but also in pharmacological and clinical-pharmacological properties. It is an anxiolytic without sedative-hypnotic, muscle relaxant and anticonvulsive effects. Tofizopam does not impair psychomotor and intellectual performance, like other benzodiazepines do, in the contrary, it has a mild stimulatory activity. It is potent in alleviating vegetative symptoms accompanying anxiety disorders. Tofizopam has a very low toxicity, mild side effects. The administration of tofizopam does not lead to physical or psychic dependence.
Somatic mutations and human breast cancer. A Status Report (1992)

A systematic study of primay human breast tumor DNA demonstrated that three proto-oncogenes or regions of the genome c-myc, int-2, and c-erbB2) are frequently amplified and that there is loss of heterozygosity (LOH) on chromosomes 1p(37%), 1q(20%), 3p(30%), 7(41%), 11p(20%), 13q(30%), 17p(49%), 17q(29%), and 18q(34%). Specific subsets of tumors can be defined based on the particular collection of mutations they contain. For instance, LOH on chromosomes 11p, 17p, and 18q frequently occurs in the same tumor. A search for putative tumor suppressor genes within the regions of the genome affected by LOH has been started. In a comprehensive molecular analysis of the p53 gene on chromosome 17p, 46% of the tumors contained a point mutation in the p53 gene. Cancer 1992; 69:1582-1588.
Quality of Vertical Dyad Linkages: Congruence of Supervisor and Subordinate Competence and Role Stress as Explanatory Variables (1985)

Supervisor and subordinate competence and role stress were ex amined as explanatory variables of the vertical exchange within supervisor/subordinate dyads. Three hypotheses were proposed to examine these linkages: (1) subordinate competence is directly related to the vertical exchange between supervisors and subordi nates; (2) this competence/exchange relationship is moderated by the role stress experienced by the parties; and (3) the subordinate competence/exchange relationship is moderated by the supervisor's competence. These hypotheses were tested using a heterogeneous sample of (626) supervisor-subordinate dyads within social service organizations. Multiple hierarchical regression that included inter action terms supported the first and third hypotheses. As subordi nate competence increased, the vertical exchange reported increased. The results also demonstrated that congruence between supervisor/ subordinate competence resulted in higher level exchanges than did incongruence in competence levels.
Synthesis of Soluble Metal Organic Framework Composites for Mixed Matrix Membranes (2019)

A general, green, efficient, and easily scalable methodology has been developed to more effectively incorporate (disperse) metal-organic frameworks (MOFs) into polymer technologies via solid state synthesis of any MOF nanocrystals within soluble mesoporous polymers. The resulting solid hybrid materials (pellets) can be directly transformed into colloidal MOF polymeric suspensions (inks) by simple dissolution in organic solvents. The straightforward use of novel colloidal MOF polymeric inks as ultimate additive for mixed matrix membranes resulted in unprecedented snakeskin microstructure exhibiting outstanding selectivity for CO<sub>2</sub> over N<sub>2</sub> (>100) from post-combustion flue gas at very low and well-dispersed MOF nanocrystal concentrations ranging from 1 to 7 wt %. This novel methodology brings one of the most versatile routes yet reported to transform any MOF into more functional forms that can be directly integrated into any conventional polymer technology at the commercial scale.
Anticonvulsant drugs in bipolar disorder (1999)

Although much progress has been made in successfully treating bipolar disorder, there is increasing awareness of the limitations of traditional treatment regimens such as lithium and neuroleptics. The large family of anticonvulsant drugs, however, appears to be capable of providing new treatment options, not only as medication of second choice in patients refractory to treatment, but often as a treatment standard with high efficacy and low incidence of side effects. Besides established mood stabilizers such as carbamazepine and valproate, new antiepileptic drugs are entering the field with promising initial results in the treatment of bipolar patients. Furthermore, bringing to light the mechanisms of action of anticonvulsants and the similarities between anticonvulsants effective in bipolar disorder may also deepen our understanding of the pathophysiological basis of the disorder.
Molecular cloning and primary structure of rat thyroxine-binding globulin (1991)

Rat thyroxine-binding globulin (TBG) cDNAs were isolated from a rat liver cDNA library by using a human TBG cDNA as a probe. From two overlapping cDNA inserts, an aligned cDNA sequence of 1714 nucleotides was obtained. There was 70% homology with human TBG cDNA over the span of 1526 nucleotides. In order to confirm that the cloned cDNA encodes rat TBG and to localize the NH2-terminal amino acid of the mature molecule, the protein was purified by affinity chromatography and subjected to direct protein microsequencing. The NH2-terminal amino acid sequence was identical with that deduced from the nucleotide sequence. The rat TBG cDNA sequenced consisted of a truncated leader sequence (35 nucleotides), the complete sequence encoding the mature protein (1194 nucleotides) and the 3'-untranslated region (485 nucleotides), containing two polyadenylation signals. It was deduced that rat TBG consists of 398 amino acids (Mr = 44,607), three NH2-terminal residues more than human TBG, with which it shares 76% homology in primary structure. Of the six potential N-glycosylation sites, four are located in conserved positions compared to human TBG. Northern blot analysis of rat liver revealed an approximately 1.8-kilobase TBG mRNA. Its amount increased markedly following thyroidectomy and decreased with thyroxine treatment in a dose-dependent manner.
SOX Antibodies in Small-Cell Lung Cancer and Lambert-Eaton Myasthenic Syndrome: Frequency and Relation With Survival (2009)

SOX antibodies are specific serological markers for SCLC. Our assay is suitable for high throughput screening, detecting 43% of SCLC. SOX antibodies have diagnostic value in discriminating SCLC-LEMS from nontumor LEMS, but have no relation to survival in patients with SCLC.
Use of the Symmetrical Number System in Resolving Undersampling Aliases. (1996)

Two algorithms are presented which allow for the unambiguous resolution of multiple undersampled frequency components in a signal. Digital signal processing is usually governed by the Nyquist criterion which limits the amount of information that can be unambiguously stored and recovered digitally to a spectral width no larger than half the sampling frequency. Both algorithms resolve a spectrum beyond Nyquist by using additional information. The first method samples a signal more than once using a different sampling frequency each time. The second method utilizes a single sampling frequency which is used to sample both the signal and a band-limited version of the signal. When using multiple sampling frequencies, each sampling frequency yields a digital sequence which, in turn, has a unique spectrum when the Discrete Fourier Transform (DFT) is applied. The bin and amplitude information from each of the resulting undersampled spectra is then recombined to resolve the original spectrum. In like manner, when using a single sampling frequency the spectra of both the signal and its band-limited version are recombined to obtain the solution. Given a sampling frequency, both algorithms allow for the unambiguous resolution of a signal with a spectral width at least twice as large as that predicted by Nyquist.
Power-bus decoupling with embedded capacitance in printed circuit board design (2003)

This paper experimentally investigates the effectiveness of embedded capacitance for reducing power-bus noise in high-speed printed circuit board designs. Boards with embedded capacitance employ closely spaced power-return plane pairs separated by a thin layer of dielectric material. In this paper, test boards with four embedded capacitance materials are evaluated. Power-bus input impedance measurements and power-bus noise measurements are presented for boards with various dimensions and layer stack ups. Unlike discrete decoupling capacitors, whose effective frequency range is generally limited to a few hundred megahertz due to interconnect inductance, embedded capacitance was found to efficiently reduce power-bus noise over the entire frequency range evaluated (up to 5 GHz).
Gene expression profiling of gastric cancer. (2014)

Our results may facilitate further therapeutic studies of gastric cancer.
Metabolic and Morphologic Disorders in Patients Treated with Highly Active Antiretroviral Therapy since Primary HIV Infection (2001)

Dyslipidemia and lipodystrophy can occur in patients treated with HAART since PHI. This risk of should be taken into account when considering this early antiretroviral treatment of HIV infection.
Regional Distribution of α<sub>2A</sub>‐and α<sub>2B</sub>‐Adrenoceptor Subtypes in Postmortem Human Brain (1992)

The newly available and highly selective radiolabeled antagonist [3H]RX 821002 was used to examine the distribution of alpha 2 adrenoceptors in human brain. High densities of alpha 2 adrenoceptors were found in the hippocampus, frontal cortex, thalamus, amygdala, pons, and medulla oblongata. Intermediate densities were observed in the striatum (nucleus accumbens, nucleus caudatus, and putamen), globus pallidus, and substantia nigra. The KD values for [3H]RX 821002 were similar in all regions (ranging from 2.8 to 7.5 nM). On the basis of their different affinities for prazosin and oxymetazoline, the alpha 2 adrenoceptors have been divided into alpha 2A and alpha 2B subtypes. To examine the alpha 2A/alpha 2B-adrenoceptor ratio in the different brain regions, we performed oxymetazoline and prazosin/[3H]RX 821002 competition binding experiments. In frontal cortex membranes, the competition curves with prazosin were steep, indicating a single class of binding sites, whereas the competition curves with oxymetazoline were shallow and fitted by computer best to a two-site model. However, in the presence of GTP, the high-affinity sites for oxymetazoline were partially converted into low-affinity sites, indicating that this agonist interacts with high- and low-affinity states of the alpha 2 adrenoceptors. This implies that oxymetazoline is not very suitable for discriminating the alpha 2A- and alpha 2B-receptor subtypes in radioligand binding studies. Therefore, prazosin/[3H]RX 821002 competition binding experiments were used to investigate the distribution of the alpha 2-adrenoceptor subtypes in human brain. The alpha 2A-receptor subtype was detected in all brain regions examined. In contrast, alpha 2B receptors were only observed in striatum and globus pallidus.
Design of a high-speed arithmetic datapath (2003)

This paper presents the implementation of a 64/32 bit floating-point datapath circuit (WTL3*64). This high-speed CMOS circuit integrates a 2 Kbit six-port register file, an independent 64/32-bit alu, a multiplier, and a divide/square-root unit for IEEE binary floating-point format numbers. It is fabricated using a 1.2 micron two-layer-metal CMOS technology. Operating at 60 ns cycle time, the 165000 transistor/147600 square mil chip provides 33 double-precision Mflops of peak performance. The register file, together with special registers, a flexible input/output interface, features for high level language support, and 1.5 Watts of power facilitate ease of integration of the device into various computer systems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Study of GMPLS lightpath setup over lambda-router networks (2003)

Generalized multi-protocol label switching (GMPLS) is currently being specified as the control plane for next-generation optical networks. This paper investigates how GMPLS affects the performance of lambda-router networks. Our performance study reveals the advantage of using a fully tunable laser at each source in the presence of a limited number of wavelength converters. We propose an enhancement to GMPLS which allows a lightpath request to crankback to a lambda router that can use a wavelength converter to complete the lightpath setup successfully. This effectively makes the wavelength converters shared across the network. It is shown that crankback provides an appreciable improvement in performance when fully tunable lasers at the sources are not universally available.
Simultaneous Determination of Triterpene Saponins in Ginseng Drugs by High-Performance Liquid Chromatography (2004)

A HPLC method for the simultaneous determination of 11 triterpene saponins with four-type aglycones (protopanaxadiol, protopanaxatriol, ocotillol and oleanolic acid types) in Ginseng drugs was developed and validated. Using a gradient of acetonitrile and 10 mM K-phosphate buffer (pH 5.80) as the mobile phase and UV detection at 196 nm, more than 18 ginsenosides with different aglycones were separated satisfactorily within 60 min. The detection limits (signal/noise> or =3) were 0.1 microg for ginsenosides Rb1, Rc, Rd, Re and Rg1, chikusetsusaponin III, and notoginsenoside R2, 0.2 microg for gisenoside Ro and chikusetsusaponin IVa, 0.3 microg for chikusetsusaponin IV, and 3 microg for majonoside R2. The calibration curve of each saponin had a correlation coefficient close to 1. Intra- and interday precisions were less than 2.1% (n=5) and 3.3% (n=15), respectively. The recovery rates of extraction were in the range of 96.4-102.7% for all ginsenosides. By adopting this method, the determinations of 11 ginsenosides in three Ginseng drugs derived from Panax ginseng, Panax vietnamensis var. fuscidiscus and Panax japonicus (Japan) were achieved.
An empirical analysis of trading volume and return volatility relationship on Istanbul stock exchange national -100 Index (2012)

It is a well-known fact that most of the asset returns tend to be skewed and heavytailed. Heavy tailed distributions such as the Studentâ€™s t distribution and Stable distribution are commonly used in finance to model asset returns that are heavy tailed. Additionally, Stable distribution allows not only for leptokurtosis but also skewness. Researchers that investigate the relationship between stock return volatility and trading volume have found a positive correlation between the volatility of returns and the volume traded. This paper focuses on this relationship by assuming the Studentâ€™s t and the Stable distributions for innovations. In this paper, GARCH and Threshold GARCH (TGARCH) models are applied on the Istanbul Stock Exchange National-100 Index with the purpose of analyzing the relationships between the volatility of stock returns and the trading volume.
ChemInform Abstract: Synthesis of Silicon‐Based Infrared Semiconductors in the Ge—Sn System Using Molecular Chemistry Methods. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Application of <sup>14</sup>N and <sup>15</sup>N NMR for Determination of Protonation Site and Hydrogen Bond Strength in Nitrogen Organic Compounds (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
FGFR2 Point Mutations in 466 Endometrioid Endometrial Tumors: Relationship with MSI, KRAS, PIK3CA, CTNNB1 Mutations and Clinicopathological Features (2012)

Mutations in multiple oncogenes including KRAS, CTNNB1, PIK3CA and FGFR2 have been identified in endometrial cancer. The aim of this study was to provide insight into the clinicopathological features associated with patterns of mutation in these genes, a necessary step in planning targeted therapies for endometrial cancer. 466 endometrioid endometrial tumors were tested for mutations in FGFR2, KRAS, CTNNB1, and PIK3CA. The relationships between mutation status, tumor microsatellite instability (MSI) and clinicopathological features including overall survival (OS) and disease-free survival (DFS) were evaluated using Kaplan-Meier survival analysis and Cox proportional hazard models. Mutations were identified in FGFR2 (48/466); KRAS (87/464); CTNNB1 (88/454) and PIK3CA (104/464). KRAS and FGFR2 mutations were significantly more common, and CTNNB1 mutations less common, in MSI positive tumors. KRAS and FGFR2 occurred in a near mutually exclusive pattern (p = 0.05) and, surprisingly, mutations in KRAS and CTNNB1 also occurred in a near mutually exclusive pattern (p = 0.0002). Multivariate analysis revealed that mutation in KRAS and FGFR2 showed a trend (p = 0.06) towards longer and shorter DFS, respectively. In the 386 patients with early stage disease (stage I and II), FGFR2 mutation was significantly associated with shorter DFS (HR = 3.24; 95% confidence interval, CI, 1.35-7.77; p = 0.008) and OS (HR = 2.00; 95% CI 1.09-3.65; p = 0.025) and KRAS was associated with longer DFS (HR = 0.23; 95% CI 0.05-0.97; p = 0.045). In conclusion, although KRAS and FGFR2 mutations share similar activation of the MAPK pathway, our data suggest very different roles in tumor biology. This has implications for the implementation of anti-FGFR or anti-MEK biologic therapies.
High-Efficiency Electrophosphorescent Fluorene-<i>alt</i>-carbazole Copolymers N-Grafted with Cyclometalated Ir Complexes (2005)

A series of electrophosphorescent conjugated fluorene-alt-carbazole copolymers are synthesized by Suzuki polycondensation. A diketone-ended alkyl chain which is grafted in the N-position of carbazole serves as a ligand to form a pendant cyclometalated Ir complex with 1-phenylisoquinoline (Piq), 2-naphthylpyridine (Napy), and 2-phenylquinoline (Phq). The PL efficiencies of PFCzIrPiq and PFCzIrPhq copolymers are around 60% and 70%, respectively. EL emission from the backbone of PFCzIrPiq and PFCzIrPhq copolymers is completely quenched even though the Ir complex contents in the polymers are as low as 0.5 mol %. The device of PFCzIrPiq05 copolymer shows the highest external quantum efficiency of 4.9% ph/el and the luminous efficiency of 4.0 cd/A with 240 cd/m2 at a bias voltage of 7.7 V and a peak emission of 610 nm. The device efficiency of PFCzIrPiq05 copolymer still remains high (QE ext = 3.4% ph/el and LE = 2.9 cd/A) with a luminance of 2978 cd/m2 even at a current density of 100 mA/cm2. The enhancement of the device performance could be due to the higher triplet energy and meanwhile to suitable HOMO and LUMO levels for efficient charge injection by introducing a carbazole unit into the polyfluorene backbone at the 3,6-linkage and blending PBD into the copolymers.