gebhart/patrepeval huggingface dataset:
The relationship between pericardial pressure and right atrial pressure: an intraoperative study. (1986)

The objective of this study was to determine the constraining effect of the normal human pericardium. Accordingly, immediately after thoracotomy in nine patients undergoing elective cardiac surgery, we measured mean pericardial surface pressure over the lateral free wall of the left ventricle with a flat balloon as well as mean right atrial pressure while incrementally infusing up to 2.1 liters of Ringer's solution to increase right atrial pressure. In each case, the slope of the relationship between right atrial (range -4 to 20 mm Hg, overall) and pericardial pressures was near unity (1.16 +/- 0.20 mean +/- SD) and the intercept was approximately zero (0.71 +/- 2.48 mm Hg). Correlation coefficients ranged from .86 to .97. These observations suggest that right atrial pressure can be used as an estimate of pericardial surface pressure. If this is the case, true left ventricular preload (i.e., effective distending pressure or transmural diastolic pressure) might be estimated from the difference between left ventricular filling pressure and right atrial pressure, both conveniently measurable clinically by means of a triple-lumen, flow-directed catheter.
From the guest editors - Universal multimedia access (2003)

Presents the guest editorial for this issue of the publication.
Identification of candidate volatiles that affect the behavioural response of the malaria mosquito <i>Anopheles gambiae sensu stricto</i> to an active kairomone blend: laboratory and semi‐field assays (2012)

Anopheles gambiae Giles sensu stricto (Diptera: Culicidae) is the most important vector of human malaria in sub‐Saharan Africa, affecting the lives of millions of people. Existing tools such as insecticide‐treated nets and indoor‐residual sprays are not only effective, but also have limitations as a result of the development of resistance to insecticides and behavioural adaptations in biting time. Therefore, novel mosquito‐control tools are needed. Odour‐releasing traps have a potential for both trapping and surveillance purposes. Based on the outcome of ex vivo gene expression assays and in vivo electrophysiological assays on hundreds of volatile organic compounds, 29 ‘candidate behaviourally‐disruptive organic compounds' (cBDOCs) are selected, belonging to 10 chemical categories, to be assayed in the laboratory using dual‐choice olfactometers for the ability to modify the ‘attractiveness’ (i.e. significantly more insects being caught in the associated trap) of a basic volatile blend consisting of ammonia, lactic acid and tetradecanoic acid but without additional carbon dioxide. Compounds that either reduce or increase trap catches by the basic blend in the olfactometer experiments are tested under African conditions in choice experiments in a semi‐field facility in Kenya. The release rates of cBDOCs are determined gravimetrically to allow the calculation of aerial concentrations at the trap outlet. Aerial concentrations in the sub‐p.p.m. range are reported for the first time to influence mosquito behaviour. The results of the olfactometer and semi‐field assays generally correspond. Under semi‐field conditions, three compounds, 3‐heptanol (0.025 p.p.m.), 2‐methylpropanal (0.05 p.p.m.) and 4,5‐dimethylthiazole (0.73 p.p.m.), significantly increase trap catches relative to the basic blend consisting of ammonia, lactic acid, tetradecanoic acid and carbon dioxide. 2‐Acetylthiophene, 2‐nonanone and 2‐phenylethanol decrease the number of mosquitoes caught at all concentrations tested under semi‐field conditions. These compounds hold promise as attractants and spatial repellents to be applied in mosquito control programmes.
Biocompatible coatings with high albumin affinity. (1991)

A process was developed to coat complex medical devices with a thin, transparent, biocompatible film. The film is based on silicone rubber (SR) but has higher albumin affinity than SR. Two polymer forms have been developed: one substitutes hydroxyl groups (OH), the other, 16 carbon acyl groups (C16) in the siloxane side chains. Oxymercuration/demercuration or hydroboration reactions can be used. SEM reveals film surfaces are smooth, uniform, and featureless. ATR/FTIR spectra and advancing/receding water contact angle measurements confirm the presence of surface OH groups and suggest the presence of surface acyl groups. Albumin adsorption and retention are markedly enhanced for surface OH and C16 concentrations as low as 5% reaction yield. Kinetics, isotherm, and competitive albumin/fibrinogen adsorption studies suggest that surface hydroxylation, and perhaps C16 acylation as well, markedly improve the albumin affinity, but not the fibrinogen affinity, of this material. The SR film can be durably coated on several materials, making it possible to favorably treat many blood-contacting devices, using a simple immersion process.
원심 모형 시험을 위한 동적 현장 지반 모사 기법 연구(대만 화련 지반) (2012)

본 연구는 원심 모형 시험을 위한 동적 현장 지반의 모사 기법을 제안하였다. 현장지반 모사를 위해서 현장 지반의 층상 구조 및 전단파 속도 주상도에 대한 자료를 바탕으로 모형시료를 조성하고, 구속압 별 공진주 시험을 수행하였다. 그리고 공진주 시험을 통하여 지반의 특성계수와 구속압 영향계수를 구하고, 모형 지반의 전단파 속도를 예측하였다. 이를 현장의 전단파 속도 주상도와 비교하여 시료 조건을 결정하였다. 그리고 결정된 시료 조건을 바탕으로 원심모형시험 모델을 제작하고, 인-플라이트 상태에서 벤더 엘리먼트 시험을 수행하여 제안된 기법의 타당성을 검증하였다. 그리고 대형지진시험이 수행된 적이 있는 대만 화련의 현장 지반을 대상으로 축소 모델링 기법을 적용하였다.
Proposed quarter squares double dual-slope digital wattmeter (1980)

A proposed a.c. digital wattmeter is described. It combines the principles of the double dual-slope multiplying analogue-digital convertor and of the quarter squares multiplier with those of the sampling digital wattmeter to provide an alternative wattmeter system where multiplication, digitising, averaging, and integration may be performed using relatively few components. The new system offers some possible advantages over a previous successful double dual-slope wattmeter.
A Study of 2,4,6-Trinitrobenzenesulfonic Acid for Automated Amino Acid Chromatography (1968)

Abstract The reaction of 2,4,6-trinitrobenzenesulfonic acid (TNBS) with amino acids was investigated by a static system to develop optimum conditions for application to automated amino acid chromatography. TNBS was found to be a very simple and sensitive reagent, easier to use than ninhydrin. The reaction occurs quite rapidly at room temperature, eliminating the requirement of a heating bath. The major disadvantage is a much lower sensitivity to the imino acid proline than to the amino acids.
Curas pedófilos en España: un testimonio (2010)

Los escandalos sobre los actos de pedofilia cometidos durante decenios por sacerdotes catolicos se suceden en varios paises: Estados Unidos, Irlanda, Alemania, etc. La actitud del Vaticano, que no ha sabido condenar y repudiar con suficiente firmeza semejantes abusos, indigna al mundo. Y resulta muy sorprendente que, hasta ahora, no abunden aun los testimonios sobre curas pedofilos en Espana, un pais en el que la Iglesia catolica, a traves de algunas de sus congregaciones religiosas especializadas (jesuitas, salesianos, escolapios, clerigos de San Viator, Opus Dei, marianistas...) ejerce tradicionalmente un excesivo control sobre la educacion de los menores. Mientras llegan esas revelaciones, he aqui un primer testimonio del escritor Ramon Chao sobre la fatal atracion que sentian por el, en su adolescencia, algunos de sus profesores sacerdotes.
The effect of temperature on <i>Agrobacterium tumefaciens</i>‐mediated gene transfer to plants (1997)

Agrobacterium tumefaciens is generally used to achieve genetic transformation of plants. The temperatures that have been used for infection with Agrobacterium in published transformation protocols differ widely and, to our knowledge, the effect of temperature on the efficiency of T‐DNA transfer to plants has not been investigated systematically. Agrobacterium tumefaciens strains harbouring a binary vector with the β‐glucuronidase ( uidA ) gene and either a nopaline‐, an octopine‐ or an agropine/ succinamopine‐type helper plasmid were tested in two transformation systems at temperatures between 15 and 29°C. One system involved cocultivation of Phaseolus acutifolius callus whereas in the other system Nicotiana tabacum leaves were vacuum‐infiltrated. In both situations, irrespective of the type of helper plasmid, the levels of transient uidA expression decreased notably when the temperature was raised above 22°C. Expression was low at 27°C and undetectable at 29°C. We anticipate that the efficiency of many published transformation protocols can be improved by reconsidering the factor of temperature.
Pneumatically Driven Environmental Control System in Aircrafts Based on a Vapor-Compression Cycle (2014)

The environmental control system is an essential subsystem of an aircraft, which has to comply some vital tasks. These include the setting of the desired temperature, humidity and cabin pressure, as well as ensuring the fresh air or oxygen supply and air quality. The requirements must be achieved in very different ambient conditions. This refers to the environmental conditions in the flight and ground cases, and also to the different climate zones. In addition, the existing interfaces to the aircraft must be taken into account. State of the art in currently used commercial aircrafts is an environmental control system, which is based on the air cycle and is driven by bleed air from the engine. This technology allows only a significantly lower coefficient of performance for the given boundary conditions compared to a vapor-compression refrigeration system. Therefore the potential application of the vapor cycle in the aircraft air conditioning system is investigated in a research project with the cooperation partner Airbus. The new system has to be developed as a replacement of the existing air cycle system. In a detailed simulation model the thermodynamic state variables are calculated for every element and different operating cases. The calculation results are then used to investigate and size the main components, e.g. heat exchangers and turbomachinery. After the optimization of the system parameters and the individual components the new system is compared with the existing system. The benchmark shows a considerably decrease of bleed air mass flow for the reference cases on ground and in flight, both at hot ambient conditions.
The Relations between Structural Changes in Small Airways and Pulmonary-Function Tests (1978)

To examine the relation between small-airways abnormalities and specific lung functions, we performed pulmonary-function tests in 36 patients, of whom two were nonsmokers, one to three days before open-lung biopsy for localized pulmonary lesions. The primary lesion in the small airways was a progressive inflammatory reaction leading to fibrosis with connective-tissue deposition in the airway walls. Increase in disease in small airways correlated with deterioration in lung function. Lesions could be reliably detected (P less than 0.05) by tests for closing capacity, the volume at which air and helium flow ere equal (a test of airway caliber and elastic recoil), and the slope of phase III of the single-breath washout curve (which tests evenness of ventilation). These tests showed abnormalities at a time when the pathologic changes were still potentially reversible and when other tests were not appreciably changed.
CSF antibodies to myelin basic protein and to myelin-associated glycoprotein in multiple sclerosis. Evidence of the intrathecal production of antibodies (1983)

Cerebrospinal fluid (CSF) from 40 multiple sclerosis (MS) patients was tested by solid-phase radioimmunoassay (RIA) for ability to bind 2 common structural components of myelin and oligodendroglia, i.e., to bind myelin basic protein (MBP) and myelin-associated glycoprotein (MAG). To prevent the effect of differences in CSF IgG concentration on binding activity, the CSF samples were tested at equal IgG concentration 1 mg/ml. The mean binding activity to MBP and MAG was significantly higher than in control neurotics, respectively P less than or equal to 0.05 and P less than or equal to 0.001. In 33% of MS cases, CSF antibody against both antigens was found. Indirect data were obtained that autoantibodies whose antigens are associated with myelin-oligodendrocyte unit are produced locally within the central nervous system (CNS). Anti-MAG and anti-MBP CSF antibody activity was significantly higher, P less than or equal to 0.01 for both antibody specificity, in MS cases characterized by high IgG Index, greater than or equal to 0.70 = means + SD in the neurotic group, versus MS cases characterized by normal IgG Index (less than or equal to 0.70). Correlation coefficient between antibody activity and IgG Index values was 0.785 for anti-MBP antibody, and 0.400 for anti-MAG antibody. The importance of intrathecally produced antibody to MBP and MAG lies in the fact that it indicates an active humoral autoimmune process against a myelin-oligodendrocyte unit in which more than one autoantigen is involved.
Short Communication: Powerless and Jobless? Comparing the Effects of Powerless Speech and Speech Disorders on an Applicant’s Employability (2013)

The present study examines the impact of a speech disorder (a lateral lisp) and powerless speech on an applicant’s hireability. College students (N = 113) reviewed an applicant’s resume, as well as a description of two occupations/job openings that varied in regard to necessitating speech. Participants listened to one of three interviews (speech disorder vs. powerless speech vs. control), indicated their willingness to hire the applicant, and then completed hire-ability and employability scales for both positions, as well as an impressions ratings form. Contrary to the hypotheses, few differences between the “employers” responses to the control and speech disorder applicants were found. The speech disorder applicant was discriminated against only when the job required speech. Powerless speech negatively affected the participants’ impressions. Compared to the other applicants, the powerless speech applicant was perceived to be the least hirable and was perceived least favorably on the majority of the impression ratings.
Bendable piezoresistive sensors by screen printing MWCNT/PDMS composites on flexible substrates (2014)

This paper presents piezoresistive sensors array, developed by screen printing of polymer nanocomposites based on multiwall carbon nanotubes (MWCNT) in poly (dimethyl-siloxane) (PDMS) matrix. The sensors are printed on 25 μm thick flexible polyethylene terephthalate (PET) substrate in the form of segmental arrays with parallel plate structures, whereby, MWCNT/PDMS nanocomposites layer is sandwiched between two printed silver plates of 1×1 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> area each. Force concentrator structures, printed on separate PET sheet, are adhered to the bottom substrate with proper alignment to the sensory cells. Three different polymer nanocomposites (by wt. %) of carbon nanotubes (MWCNT) in PDMS matrix have been investigated here for possible application as a tactile sensor in an electronic skin for robots and general purpose applications. The change in resistance value is observed when structures are subjected to normal compressive forces as well as when they are bent.
Generation, Editing, and Visualization of 3D Video (2002)

D video is the ultimate image medium recording dynamic visual events in the real world as is. Recorded object behaviors can be observed from any viewpoint, because 3D video records the object's full 3D shape, motion, and precise surface properties (i.e. color and texture). In this paper, we present research attainments so far obtained: 1. a PC cluster system for real-time reconstruction of dynamic 3D object behaviors from multi-view video images, 2. an active 3D mesh model for reconstructing the accurate 3D object shape, 3. an algorithm of generating natural-looking texture on the 3D object surface from the multi-view video images, and 4. an editing system for visualizing 3D video with an omni-directional background image using versatile 3D camera works. Experimental results demonstrate the eectiveness of these methods in generating high fidelity and attractive object images from arbitrary viewpoints.
Enhanced Release of Elastase Is Not Concomitant With Increased Secretion of Granulocyte-Activating Cytokines in Whole Blood From Patients With Sepsis (1994)

These data indicate an increased release of elastase by PMN despite a reduced secretion of PMN-activating cytokines. Although priming effects of TNF-alpha, IL-1 beta, and IL-8 on protease secretion in vivo cannot be excluded completely, other mediators or mechanisms may be involved in the upregulation of detrimental protease release during sepsis.
Antibody Responses to the Three Genomic Groups of Borrelia burgdorferi in European Lyme Borreliosis (1994)

The antibody responses to the three genomic groups of Borrelia burgdorferi (B. burgdorferi sensu stricto, Borrelia garinii, and Borrelia afzelii) were determined in 97 German patients with various manifestations of Lyme borreliosis. The geometric mean antibody titers in each patient group, determined by ELISA, were similar with each antigen preparation. By Western blotting, however, patients with meningopolyneuritis tended to respond to more spirochetal polypeptides of B. garinii, the group 2 strain, whereas those with arthritis recognized more antigens of B. afzelii, the group 3 strain (P < .03), as did those with acrodermatitis. Only 1 patient each with erythema migrans, arthritis, or acrodermatitis had weak reactivity with outer surface protein A (OspA), and none responded to OspB. It is concluded that differences among the three groups of B. burgdorferi may result in variations in the antibody response in European Lyme borreliosis.
WTA-based interleaved buck converters for low-voltage high-current applications (2004)

This paper studies interleaved buck converters using a switching rule based on a winner-take-all (WTA) principle. The system can realize multi-phase synchronization automatically: it enables us to realize ripple reduction of the output current and high tolerance for subsystem failure. Using the piecewise constant model, we clarify parameters conditions for existence and stability of the synchronous states. The simple test circuit is presented and typical synchronous phenomena are verified in the laboratory.
Impact of power system blackouts (2015)

This article consists of a collection of slides from the author's conference presentation.
Comparative Study of the Cytotoxicity and Genotoxicity of Alpha- and Beta-Asarone (2012)

The cytotoxicity of alpha- and beta-asarone was investigated with the BrdU assay in HepG2-cells. Alpha-asarone was found to be more toxic than beta-asarone after 24 hours of treatment. Investigation of the genotoxicity using the micronucleus assay in the HepG2-cell system showed that only after metabolic activation by a liver microsomal preparation, beta-asarone was able to induce micronuclei at concentrations higher than 50 μg/mL.
Closed Loop Control of the EGR Rate Using the Oxygen Sensor (1988)

An effective method for reducing NOx emissions from automotive engines is the recirculation of the exhaust gas (EGR) to dilute the induced fresh air charge. EGR systems are currently applied mostly with open-loop control. A new closed-loop control system for EGR rate has been developed. The most important point of this system is use of the feedback signal based on oxygen density at the intake charge for the engine
Free radical signalling underlies inhibition of Ca<sub>V</sub>3.2 T‐type calcium channels by nitrous oxide in the pain pathway (2010)

Nitrous oxide (N2O, laughing gas) has been used as an anaesthetic and analgesic for almost two centuries, but its cellular targets remain unclear. Here, we present a molecular mechanism of nitrous oxide's selective inhibition of CaV3.2 low-voltage-activated (T-type) calcium channels in pain pathways. Using site-directed mutagenesis and metal chelators such as diethylenetriamine pentaacetic acid and deferoxamine, we reveal that a unique histidine at position 191 of CaV3.2 participates in a critical metal binding site, which may in turn interact with N2O to produce reactive oxygen species (ROS). These free radicals are then likely to oxidize H191 of CaV3.2 in a localized metal-catalysed oxidation reaction. Evidence of hydrogen peroxide and free radical intermediates is given in that N2O inhibition of CaV3.2 channels is attenuated when H2O2 is neutralized by catalase. We also use the adrenochrome test as an indicator of ROS in vitro in the presence of N2O and iron. Ensuing in vivo studies indicate that mice lacking CaV3.2 channels display decreased analgesia to N2O in response to formalin-induced inflammatory pain. Furthermore, a superoxide dismutase and catalase mimetic, EUK-134, diminished pain responses to formalin in wild-type mice, but EUK-134 and N2O analgesia were not additive. This suggests that reduced ROS levels led to decreased inflammation, but without the presence of ROS, N2O was not able to provide additional analgesia. These findings reveal a novel mechanism of interaction between N2O and ion channels, furthering our understanding of this widely used analgesic in pain processing.
Chitin Synthesis in <i>Saccharomyces cerevisiae</i> in Response to Supplementation of Growth Medium withGlucosamine and Cell WallStress (2003)

In Saccharomyces cerevisiae most chitin is synthesized by Chs3p, which deposits chitin in the lateral cell wall and in the bud-neck region during cell division. We have recently found that addition of glucosamine (GlcN) to the growth medium leads to a three- to fourfold increase in cell wall chitin levels. We compared this result to the increases in cellular chitin levels associated with cell wall stress and with treatment of yeast with mating pheromone. Since all three phenomena lead to increases in precursors of chitin, we hypothesized that chitin synthesis is at least in part directly regulated by the size of this pool. This hypothesis was strengthened by our finding that addition of GlcN to the growth medium causes a rapid increase in chitin synthesis without any pronounced change in the expression of more than 6,000 genes monitored with Affymetrix gene expression chips. In other studies we found that the specific activity of Chs3p is higher in the total membrane fractions from cells grown in GlcN and from mutants with weakened cell walls. Sucrose gradient analysis shows that Chs3p is present in an inactive form in what may be Golgi compartments but as an active enzyme in other intracellular membrane-bound vesicles, as well as in the plasma membrane. We conclude that Chs3p-dependent chitin synthesis in S. cerevisiae is regulated both by the levels of intermediates of the UDP-GlcNAc biosynthetic pathway and by an increase in the activity of the enzyme in the plasma membrane.
Endometrial collection and interpretation using the Tao brush and the CytoRich fixative system: A feasibility study (1997)

Endometrial brushing with suspension-fixation is advocated for the detection of endometrial lesions because (1) fixation is uniform, (2) there is substantial preservation of three-dimensional structures among cell aggregates, which allows pattern-based histologic diagnostic criteria to be applied to cytologic samples, and (3) only a limited number of slides need to be examined.