gebhart/patrepeval huggingface dataset:
Single-Domain Antibodies As Therapeutics against Human Viral Diseases (2017)

In full-size formats, monoclonal antibodies have been highly successful as therapeutics against cancer and immune diseases. However, their large size leads to inaccessibility of some epitopes and relatively high production costs. As an alternative, single-domain antibodies (sdAbs) offer special advantages compared to full-size antibodies, including smaller size, larger number of accessible epitopes, relatively low production costs and improved robustness. Currently, sdAbs are being developed against a number of viruses, including human immunodeficiency virus-1 (HIV-1), influenza viruses, hepatitis C virus (HCV), respiratory syncytial virus (RSV), and enteric viruses. Although sdAbs are very potent inhibitors of viral infections, no sdAbs have been approved for clinical use against virial infection or any other diseases. In this review, we discuss the current state of research on sdAbs against viruses and their potential as therapeutics against human viral diseases.
Divergence of reproductive phenology under climate warming (2006)

Because the flowering and fruiting phenology of plants is sensitive to environmental cues such as temperature and moisture, climate change is likely to alter community-level patterns of reproductive phenology. Here we report a previously unreported phenomenon: experimental warming advanced flowering and fruiting phenology for species that began to flower before the peak of summer heat but delayed reproduction in species that started flowering after the peak temperature in a tallgrass prairie in North America. The warming-induced divergence of flowering and fruiting toward the two ends of the growing season resulted in a gap in the staggered progression of flowering and fruiting in the community during the middle of the season. A double precipitation treatment did not significantly affect flowering and fruiting phenology. Variation among species in the direction and magnitude of their response to warming caused compression and expansion of the reproductive periods of different species, changed the amount of overlap between the reproductive phases, and created possibilities for an altered selective environment to reshape communities in a future warmed world.
Transparent offloading and mapping (TOM) (2016)

Main memory bandwidth is a critical bottleneck for modern GPU systems due to limited off-chip pin bandwidth. 3D-stacked memory architectures provide a promising opportunity to significantly alleviate this bottleneck by directly connecting a logic layer to the DRAM layers with high bandwidth connections. Recent work has shown promising potential performance benefits from an architecture that connects multiple such 3D-stacked memories and offloads bandwidth-intensive computations to a GPU in each of the logic layers. An unsolved key challenge in such a system is how to enable computation offloading and data mapping to multiple 3D-stacked memories without burdening the programmer such that any application can transparently benefit from near-data processing capabilities in the logic layer. Our paper develops two new mechanisms to address this key challenge. First, a compiler-based technique that automatically identifies code to offload to a logic-layer GPU based on a simple cost-benefit analysis. Second, a software/hardware cooperative mechanism that predicts which memory pages will be accessed by offloaded code, and places those pages in the memory stack closest to the offloaded code, to minimize off-chip bandwidth consumption. We call the combination of these two programmer-transparent mechanisms TOM: Transparent Offloading and Mapping. Our extensive evaluations across a variety of modern memory-intensive GPU workloads show that, without requiring any program modification, TOM significantly improves performance (by 30% on average, and up to 76%) compared to a baseline GPU system that cannot offload computation to 3D-stacked memories.
Wild-type p53 renders mouse astrocytes resistant to 1,3-Bis(2-chloroethyl)-1-nitrosourea despite the absence of a p53-dependent cell cycle arrest [corrected]. (1996)

We examined the response of normal and p53-deficient mouse astrocytes to the alkylating agent 1,3-bis(2-chloroethyl)-l-nitrosourea (BCNU), a clinically useful DNA-damaging drug to which some human astrocytomas are resistant and some are sensitive. Astrocyte cultures were isolated from the cerebrums of wild-type, heterozygous, and knockout p53 neonatal mice and treated with various concentrations of BCNU. Wild-type p53 astrocytes were significantly more resistant to BCNU than were knockout p53 astrocytes, with heterozygous astrocytes exhibiting an intermediate level of resistance, Cell cycle analysis showed that wild-type p53 astrocytes treated with BCNU demonstrated a decline in the percentage of cells in G1 and an increase in the percentage of cells in G2. Similar cell cycle responses to BCNU occurred in knockout p53 astrocytes, suggesting that this effect was p53 independent. In contrast, G1 arrest was observed in wild-type astrocytes exposed to ionizing radiation and was not observed in knockout astrocytes, indicating a p53-dependent response. Our findings point to an as yet uncharacterized p53-associated mechanism of resistance to BCNU in mouse astrocytes.
A simple procedure for measuring pharyngeal sensitivity: a contribution to the diagnosis of sleep apnoea (2005)

This simple and safe procedure showed that impairment of pharyngeal sensitivity is correlated with severity of SDB. Using this test in routine clinical practice may simplify the diagnosis of sleep apnoea, particularly for the most severe patients.
Structural analysis of wild-type and mutant human immunodeficiency virus type 1 Tat proteins (1990)

We expressed the human immunodeficiency virus type 1 transactivator protein, Tat, in the wheat germ cell-free translation system and found it to exist as a monomer. The first coding exon (residues 1 to 72) of wheat germ-expressed Tat was resistant to trypsin digestion, indicating that it is a highly folded, independently structured protein domain. Several mutant Tat proteins were dramatically more sensitive to trypsin than the wild type was, suggesting that their reduced transactivation activities are the result of destabilized structures. Mutant proteins with single-amino-acid substitutions were also identified that had reduced transactivation activities but wild-type structures in the trypsin assay. These mutants clustered in two regions of Tat, at acidic residues 2 and 5 in the amino terminus and between residues 18 and 32. These mutants, wild type in structure but reduced in activity, identify residues in the wild-type protein that may directly contact other molecules during Tat function.
NMR <i>T2</i> Distributions in the Eagle Ford Shale: Reflections on Pore Size (2013)

Abstract Production of oil from organic shale reservoirs is a function of porosity, hydrocarbon saturation, pore pressure, matrix permeability, and hydraulic fracture surface area plus fracture conductivity. Hydraulic fracture surface area, porosity, saturations and pore pressure dominate initial production rates. Matrix permeability becomes increasingly important in sustaining production later in time. Permeability measurements to oil from organic shale core samples are not commercially available today. However, permeability to oil is believed to be a function of pore throat size, wettability, and water saturation, the same as a conventional reservoir. This work investigates pore size, wettability, and expelled hydrocarbon volumes using log and core-based nuclear magnetic resonance data from the Eagle Ford Shale focused on the comprehensive evaluation of one well. Comparisons with core porosity measurements, scanning electron microscope images (SEM) and mercury injection capillary pressure tests (MICP) are compared with the nuclear magnetic resonance (NMR) interpretation for calibration and validation. The NMR T2 distribution is partitioned into regions of bound and producible free fluid. Two types of pore systems are present in the Eagle Ford Shale; kerogen-hosted (OM) and inter/intra particle (IP). Bore hole logs indicate the upper Eagle Ford Shale is dominated by IP porosity, and the lower Eagle Ford Shale is dominated by OM porosity. Core NMR indicates OM pores are hydrocarbon wet while IP pores have mixed wettability. Core pore fluids are not representative of in-situ conditions as the lighter portion of the hydrocarbons have been expelled during core recovery. Comparison between log and core measured NMR allows the quantification of the expelled hydrocarbon - those zones with the "best" producibility. Understanding which portion of a shale reservoir contains producible fluids impacts target zone selection.
Searchable Objects (2015)

This paper examines mobile internet search, presenting search not as a process of information retrieval, but as part of conversation and talk. Through video extracts of mobile search we explore how mobile phones are interwoven into talk, and how searchers manage the participation of other conversationalists alongside the search itself. We introduce the notion of a 'searchable object' -- an object that arises in conversation that can be searched for online -- and document how such an object occasions a search. In turn we discuss the differing roles of the device 'driver' and 'passenger', and how participation is managed through questions and narration. Rather than search being solely about getting correct information, conversations around search may be just as important. We conclude by critiquing some of the pessimistic views of interaction around mobile phones and their use in ordinary life and talk.
Do visual art experiences in early childhood settings foster educative growth or stagnation (2016)

This article offers findings from research that examined the visual art beliefs and pedagogy of early childhood educators and supports reflection about the educational merit of different types of visual art experience offered to children. The range of visual art experiences typically delivered in early childhood education settings varies significantly in method and purpose, yet there is little guidance to support early childhood educators to evaluate the visual art experiences they include in the curriculum or to consider their role as art educators. At the same time, the research literature suggests that pre- school educators lack confidence to make and teach art and that their visual art subject knowledge is limited. Qualitative case study research examined the visual art beliefs and pedagogy of twelve educators located in four Australian early childhood education settings. Data collection methods included interviews, environmental audits and analysis of pedagogical documentation about visual art provisions. John Dewey's philosophies of democracy, education and art synthesised with the philosophy and pedagogical values of the Reggio Emilia educational approach support interpretation and analysis of the research data. In particular, Dewey's philosophy of consummatory experience and growth alongside Eisner's discussions about visual art myths and null curricula guide reflection about visual art provisions in early childhood contexts. A continuum of visual art experience is proposed to support reflection about the types of experience that potentially mis- educate and lead to visual art stagnation compared with experiences that may foster consummatory and educative growth.
Increased Incidence of Acute Leukemia in Polycythemia Vera Associated with Chlorambucil Therapy (1981)

In studies to determine the optimal treatment for polycythemia vera, 431 previously untreated patients whose disease met established diagnostic criteria were entered into a prospective, randomized controlled trial between 1967 and 1974. Three treatment regimens were used: phlebotomy alone, chlorambucil supplemented by phlebotomy, or radioactive phosphorus supplemented by phlebotomy. Despite minor differences in age and sex, the three groups were comparable in initial hematocrit, white-cell and platelet counts, and disease-related symptoms. The median duration of follow-up is now more than 6 1/2 years. As of February 15, 1980, there were no statistically significant differences in survival among the groups. However, the risk of acute leukemia in patients given chlorambucil was 2.3 times that in patients given radioactive phosphorus and 13 times that in patients treated with phlebotomy alone. The increased incidence of leukemia during chlorambucil treatment is statistically significant (P less than or equal to 0.002); accordingly, the Polycythemia Vera Study Group has discontinued the use of chlorambucil in the treatment of polycythemia vera.
Prevalence of chronic wounds in Quebec home care: an exploratory study. (2006)

Because the prevalence of chronic wounds in Quebec is unknown, researchers conducted a chronic wound prevalence feasibility study in severely ill, elderly, or bedridden home care patients. Questionnaires seeking information about the number of wounds, patient comorbidities, and characteristics of the most severe wound (etiology, location, duration, progress, and treatments) were mailed to the head nurse and home care nurses of 149 local community health centers. Information regarding nurse and general health center needs related to chronic wound prevention and care also was solicited from nurses in 52 health centers. Data were obtained from 488 patients (average age 68.5 years); an overall prevalence rate of 1.4% was determined. Most patients (81%) had one or two wounds and pressure ulcer was the most common etiology (37% of wounds). Wounds had existed for a mean of 26.8 months (range 0 to 180, median 12 months). Most (94%) patients had a family physician but only one third of family physicians were responsible for the wound care provided/prescribed. Lack of time was the most frequently cited reason for not completing the survey. Wound chronicity, severity (44% of pressure ulcers were Stage III), lack of improvement (60% cited no improvement or worsening of ulcer), the absence of protocols and training in some local community service centers, and inappropriate use of therapeutic modalities are important reasons for concern and provide opportunities for improvement. Sample size and the absence of verifiable data limit the external validity of the findings but results indicate that chronic wounds are a common and important concern among home healthcare patients in Quebec. Improvements in data collection and patient protocols of care are needed to facilitate the acquisition of much-needed wound prevalence and outcomes data to help agencies provide optimal patient care.
Thin Film Technology: Adhesion in Thin Films (2004)

Last month I addressed the subject of pinholes in thin films and ways to minimize them. The subject this month is another cause for success, or failure, of thin films, adhesion. I was motivated to discuss this horrendously complicated subject by a conference I recently attended, Adhesion Aspects of Thin Films (Orlando, December 15-17). This conference, organized by Dr.'s K.L. Mittal and R.H. Lacombe, was both stimulating and informative.
Dissociation of Chemotaxis from Agonist-induced Receptor Internalization in a Lymphocyte Cell Line Transfected with CCR2B (1997)

To investigate the role of the carboxyl-terminal region (52 amino acids) of the monocyte chemoattractant protein 1 receptor (CCR2B) in chemotaxis, we created a series of mutants and expressed them in a murine pre-B lymphocyte cell line. Truncation of the cytoplasmic carboxyl tail to 20 amino acids had little or no effect on chemotaxis or signal transduction, but further truncation resulted in marked functional defects. Upon incubation with monocyte chemoattractant protein 1, CCR2B underwent rapid and extensive internalization, and this was impaired progressively as the carboxyl tail was truncated from 52 to 8 amino acids. Mutation of all of the serine and threonine residues in the carboxyl tail to alanine also resulted in markedly impaired receptor internalization but did not affect signaling or chemotaxis. We conclude that the membrane-proximal portion of the cytoplasmic carboxyl tail of CCR2B is critically involved in chemotaxis and signal transduction, but neither phosphorylation of carboxyl serines or threonines nor internalization of the receptor is required for robust chemotaxis.
Deriving the multiplicative algebraic reconstruction algorithm (MART) by the method of convex projection (POCS) (1993)

It is shown that the MART (multiplicative algebraic reconstruction technique) algorithm can be derived by POCS. This gives MART a new theoretical interpretation and a proof of convergence to a stable solution even when other convex constraints are introduced. However, MART, as a multiplicative algorithm, depends on the initial solution. It is noted that, far from being a flaw, this property can be used to introduce further a priori knowledge about the image to be reconstructed, to maximize the entropy, to keep the ratio between the regions of the original image constant, or to set to zero the area outside the reconstruction volume. MART should be preferred to MENT (a maximum entropy algorithm) for entropy maximization, for it performs as well but is much faster. ART is much less influenced by the initial solution than MART.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Parameter-free Sentence Embedding via Orthogonal Basis (2019)

Ziyi Yang, Chenguang Zhu, Weizhu Chen. Proceedings of the 2019 Conference on Empirical Methods in Natural Language Processing and the 9th International Joint Conference on Natural Language Processing (EMNLP-IJCNLP). 2019.
Real-time recognition of U.S. speed signs (2008)

In this paper a camera-based system for detection, tracking, and classification of U.S. speed signs is presented. The implemented application uses multiple connected stages and iteratively reduces the number of pixels to process for recognition. Possible sign locations are detected using a fast, shape-based interest operator. Remaining objects other than speed signs are discarded using a classifier similar to the Viola-Jones detector. Classification results from tracked candidates are utilized to improve recognition accuracy. On a standard PC the system reached a detection speed of 27 fps with an accuracy of 98.8%. Including classification, speed sign recognition rates of 96.3% were achieved with a frame rate of approximately 11 fps and one false alarm every 42 s.
Identification, sequencing, and enzymatic activity of the erythrose-4-phosphate dehydrogenase gene of Vibrio cholerae (1997)

We have identified a gene in Vibrio cholerae (epd) which encodes an erythrose-4-phosphate dehydrogenase activity and is located immediately downstream of an iron-regulated virulence gene, irgA, and immediately upstream of a gene encoding phosphoglycerate kinase (pgk). Expression of epd in V. cholerae is not regulated by iron, nor is it required for virulence in an infant mouse model.
Chemical synthesis of 5beta-cholestane-3alpha, 7alpha, 24, 25-tetrol and its metabolism in the perfused rabbit liver (1978)

5beta-[G-3H]Cholestane-3alpha, 7alpha, 24xi, 25-tetrol (IV) was synthesized via dehydration and peroxidation of 5beta-[G-3H]cholestane-3alpha, 7alpha, 25-triol. Following perfusion of the labeled compound in the isolated rabbit liver, the bile alcohol and bile acid metabolites secreted into the bile were identified by a combination of thin layer chromatography, gas-liquid chromatography, and gas-liquid chromatography/mass spectrometry. The following bile alcohols were tentatively identified: 5beta-cholest-23-ene-3alpha, 7alpha, 25-triol, 5beta-cholest-25-ene-3alpha, 7alpha, 12alpha, 24xi-tetrol, and 5beta-cholestane-3alpha, 7alpha, 12alpha, 24xi, 25-pentol. The amount of administered tetrol recovered unchanged ranged from 1 to 88%. Cholic acid was the major product, but limited amounts of chemodeoxycholic acid were also formed. The 24-hydroxyl group in the steroid side chain did not prevent 12alpha-hydroxylation.
A Timer For Spark Breakdown Studies (1941)

As an aid in the study of the time lag of spark breakdown, devices have been constructed to apply a rectangular voltage wave and to measure its length which is from one to 5000 microseconds in duration. Oscillograms of switching transients and test-gap voltages in this investigation indicate that many previous investigators have been deceived in assuming a rectangular wave of applied voltage, and that others may have introduced errors by assuming the gap voltage to be influenced by reflections. It is possible to apply an essentially rectangular voltage by (1) maintaining the spark which closes the circuit through the applying switch before the contacts meet mechanically, and (2) by making the test-gap circuit aperiodic. The length of the applied voltage wave is determined by a vacuum tube circuit designed to pass a constant current output as long as the bias to the first tube exceeds a predetermined value. The output current is passed through a ballistic galvanometer whose reading is a measure of the time during which the gap voltage remains above the datum level. A thyratron circuit has been arranged to supply the timer with rectangular waves for the purpose of calibration. Cathode-ray oscillograms showing errors of 5 percent to 10 percent indicate that the accuracy of the apparatus is sufficient for most breakdown studies.
Interleukin 10 and interferon gamma regulation of experimental Trypanosoma cruzi infection. (1992)

Studies were undertaken to determine whether interleukin 10, (IL-10) a cytokine shown to inhibit interferon gamma (IFN-gamma) production, was involved in Trypanosoma cruzi infections in mice. Exogenous IFN-gamma protects mice from fatal infection with T. cruzi. Furthermore, resistant B6D2 mice developed fatal T. cruzi infections when treated with neutralizing anti-IFN-gamma monoclonal antibody (mAb). Thus, endogenous as well as exogenous IFN-gamma is important in mediating resistance to this parasite. Because both T. cruzi-susceptible (B6) and -resistant (B6D2) mouse strains produced IFN-gamma during acute infection, we looked for the concomitant production of mediators that could interfere with IFN-gamma-mediated resistance to T. cruzi. We found that IL-10-specific mRNA was produced in the spleens of mice with acute T. cruzi infections. In addition, spleen cell culture supernatants from infected B6 mice, and to a lesser extent B6D2 mice, elaborated an inhibitor(s) of IFN-gamma production. This inhibitor(s) was neutralized by anti-IL-10 mAb. These experiments demonstrated the production of biologically active IL-10 during T. cruzi infection. In further studies in vitro, it was shown that IL-10 blocked the ability of IFN-gamma to inhibit the intracellular replication of T. cruzi in mouse peritoneal macrophages. Thus, in addition to its known ability to inhibit the production of IFN-gamma, IL-10 (cytokine synthesis inhibitory factor), may also inhibit the effects of IFN-gamma. These experiments demonstrate that IL-10 is produced during infection with a protozoan parasite and suggest a regulatory role for this cytokine in the mediation of susceptibility to acute disease.
The C–O Bond Cleavage of Allyl Ethers by Rhodium Compounds (1975)

Abstract Allyl ethers were cleaved by rhodium compounds under mild conditions to give aldehydes and hydrocarbons. This reaction can be extended to allyl esters.