gebhart/patrepeval huggingface dataset:
An improved 3 V 2 GHz BiCMOS image reject mixer IC (2002)

A 2 GHz BiCMOS image reject mixer is described in this paper. A novel combination of 90/spl deg/ phase shifter networks and a gain control system are used to obtain high image rejection despite local oscillator frequency variation due to channel selection, intermediate frequency (IF) adjustment and process fluctuations. A 35 dB min. image rejection is obtained in a 200 MHz RF bandwidth centered at 2 GHz and a 200 MHz IF. Furthermore, the gain control system allows a 25 dB min. image rejection for IF adjustment from 100 MHz to 300 MHz. The conversion gain of the mixer is 10 dB and the IP3 is -4,5 dBm referenced to the input. The overall current consumption is 15 mA from a +3 V supply. The mixer has been integrated in a front end IC including an antenna preamplifier in a silicon BiCMOS process.
Rv1218c, an ABC Transporter of <i>Mycobacterium tuberculosis</i> with Implications in Drug Discovery (2010)

Efflux systems are important in determining the efficacy of antibiotics used in the treatment of bacterial infections. In the last decade much attention has been paid to studying the efflux pumps of mycobacteria. New classes of compounds are under investigation for development into potential candidate drugs for the treatment of tuberculosis. Quite often, these have poor bactericidal activities but exhibit excellent target (biochemical) inhibition. Microarray studies conducted in our laboratories for deciphering the mode of action of experimental drugs revealed the presence of putative ABC transporters. Among these transporters, Rv1218c was chosen for studying its physiological relevance in mediating efflux in Mycobacterium tuberculosis. A ΔRv1218c mutant of M. tuberculosis displayed a 4- to 8-fold increase in the inhibitory and bactericidal potency for different classes of compounds. The MICs and MBCs were reversed to wild-type values when the full-length Rv1218c gene was reintroduced into the ΔRv1218c mutant on a multicopy plasmid. Most of the compound classes had significantly better bactericidal activity in the ΔRv1218c mutant than in the wild-type H37Rv, suggesting the involvement of Rv1218c gene product in effluxing these compounds from M. tuberculosis. The implication of these findings on tuberculosis drug discovery is discussed.
Use of a multivitamin, mineral and herbal supplement to improve memory, mood and stress (2011)

With aging of the world population, there is demonstrated age-associated cognitive decline and a rising prevalence of depression and anxiety. Population studies show that vitamin deficiency, cardiovascular disease, elevated homocysteine and cellular metabolic dysfunction are risk factors for cognitive decline, dementia and other pathological conditions of aging. Growing evidence indicates that dietary supplementation and selected vitamins and minerals may improve risk parameters and consequently improve cognitive function. A series of experiments have been conducted investigating the role of nutrients and herbs on mood, stress, memory and cognition: 1. The effects of a multivitamin/mineral/herbal supplement on mood and stress in a group of healthy older male volunteers. This RDBPC trial of 50 men, aged 50-69 years were supplemented for a period of 8 weeks. 2. A RDBPC trial was undertaken to investigate the effect of 16 weeks multivitamin (at levels above recommended daily intakes)/mineral/herbal supplement on cognition in 56 elderly women. Cognition was measured with a battery of memory and attention tasks designed to be sensitive to age-related reduction to fluid intelligence plus a measure of verbal recall. Biochemical measures of a number of nutrients, homocysteine, markers of inflammation, oxidative stress and blood safety parameters were carried out. Results were assessed at baseline and after 16 weeks of treatment. 3. Role of Pinus radiata bark extract formulation. A RDBPC study investigated the effects on cognitive performance of a 5 week supplementation with Enzogenol® Pinus Radiata bark extract containing flavonoids53. Forty-two males aged 50-65 years with a BMI> 25 were studied. This series of studies have demonstrated that a multivitamin/mineral/herbal supplement a) May improve alertness, reduce depression, anxiety and stress in non-depressed older adults b) May benefit memory performance in elderly women of risk in cognitive decline c) Pinus radiata bark extract can improve cognition in elderly men.
Using information theory to search for co-evolving residues in proteins (2005)

All data and program files can be found at http://www.biochem.uwo.ca/cgi-bin/CDD/index.cgi
One-third terabit/s transmission through 150 km of dispersion-managed fiber (1995)

340 Gb/s (seventeen 20-Gb/s 2/sup 31/-1 PRBS NRZ channels) were transmitted through 150 km of fiber with 50 km amplifier spacing. Chromatic dispersion penalties and four-photon mixing effects were minimized by dispersion management.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Mobile Marketing in the Retailing Environment: Current Insights and Future Research Avenues (2010)

Mobile marketing, which involves two- or multi-way communication and promotion of an offer between a firm and its customers using the mobile, a term that refers to the mobile medium, device, channel, or technology, is growing in importance in the retailing environment. It has the potential to change the paradigm of retailing from one based on consumers entering the retailing environment to retailers entering the consumer's environment through anytime, anywhere mobile devices. We propose a conceptual framework that comprises three key entities: the consumer, the mobile, and the retailer. The framework addresses key related issues such as mobile consumer activities, mobile consumer segments, mobile adoption enablers and inhibitors, key mobile properties, key retailer mobile marketing activities and competition. We also address successful retailer mobile marketing strategies, identify the customer-related and organizational challenges on this topic, and outline future research scenarios and avenues related to these issues.
Code transformations and SIMD impact on embedded software energy/power consumption (2009)

The increasing demand for portable computing has elevated power consumption to be one of the most critical embedded systems design parameters. In this paper, we present a qualitative study wherein we examine the impact of code transformations on the energy and power consumption. Three main categories of code transformations are investigated, namely data, loop and procedural oriented transformations. Moreover, we evaluate the influence of employing single instruction multiple data (SIMD) on energy and power dissipation via the utilization of compiler intrinsic C-functions. Results show that a trade-off between power and performance can be achieved by employing the intrinsic C-functions in conjunction with some transformations such as loop unrolling and procedure integration.
PATTERNS OF ENGRAFTMENT IN DIFFERENT STRAINS OF IMMUNODEFICIENT MICE RECONSTITUTED WITH HUMAN PERIPHERAL BLOOD LYMPHOCYTES1 (2001)

Our data indicate that a high rate of reconstitution with human lymphocytes can be achieved in scid-beige, NOD-scid, and NOD-scid-beta2 m- mice. Human Ig are produced at high levels, except in NOD-scid-beta2 m-, including xenoreactive natural antibodies. Scid-beige and NOD-scid appear therefore better suited than NOD-scid-beta2 m- or rag- for analysis of human immunoreactivity in vivo. An important caveat is the invariable occurrence of GVHD that precludes long-term studies in this model system.
An experimental integrated workstation for teleconferencing (1994)

This paper gives a brief description of an integrated workstaton based on the IBM PC for use as a videoconferencing terminal for communication over an integrated services digital network using asynchronous transfer mode. The MASTER (Multimedia AidS for TeleconfERencing) project, funded largely by the Science and Engineering Research Council, was set up to investigate a low-cost teleconferencing environment suitable for operation across an ISDN. When this project was first conceived telephone-based teleconferencing systems was already in use, but were still quite expensive to install. It was felt that technological advances were making possible the reception, and play-back, of pictures and sound on ordinary desk-top computers, which would provide the basis for low-cost teleconferencing systems. Towards the end of this project, these advances have received recognition, first, through the production of 'multimedia personal computers', and more recently, by the announcement of low-cost teleconferencing (video/audio) systems.
Identification and characterization of plant agmatine iminohydrolase, the last missing link in polyamine biosynthesis of plants (2003)

The cloning, expression and characterization of plant agmatine iminohydrolase (AIH, also known as agmatine deiminase, EC 3.5.3.12) is described. Recombinant AIH of Arabidopsis thaliana forms dimers and catalyzes the specific conversion of agmatine to N-carbamoylputrescine and ammonia. Biochemical data suggested that cysteine side chains are involved in catalysis. However, site-directed mutagenesis of the two highly conserved cysteine residues of AIH showed that these cysteines are important but not essential for activity, arguing against a thioester substrate-enzyme intermediate during catalysis. This work represents the completion of the cloning of the arginine decarboxylase pathway genes of higher plants.
Joint Demosaicking and Denoising by Fine-Tuning of Bursts of Raw Images (2019)

Demosaicking and denoising are the first steps of any camera image processing pipeline and are key for obtaining high quality RGB images. A promising current research trend aims at solving these two problems jointly using convolutional neural networks. Due to the unavailability of ground truth data these networks cannot be currently trained using real RAW images. Instead, they resort to simulated data. In this paper we present a method to learn demosaicking directly from mosaicked images, without requiring ground truth RGB data. We apply this to learn joint demosaicking and denoising only from RAW images, thus enabling the use of real data. In addition we show that for this application fine-tuning a network to a specific burst improves the quality of restoration for both demosaicking and denoising.
Visual Decrement with Deposit Accumulation on HEMA Contact Lenses (1988)

The vision decrement associated with deposit accumulation on hydroxyethyl methacrylate (HEMA) contact lenses was assessed in 51 patients presenting consecutively to a large clinic. Both high contrast visual acuity (HCA) and low contrast visual acuity (LCA) (logMAR) decreased with increased deposition (Rudko classification). Apart from being consistently lower than HCA, LCA offered no additional useful information. Both HCA and LCA worsened with lens age, whilst lens deposition increased with lens age (p less than 0.001). No associations between any of the above measures and patient symptoms were revealed. In general, unacceptable vision decrement and deposit formation occurred after 12 months or 4,000 h of daily lens wear. Clinicians can use the data presented in this paper to reconcile vision loss with deposit formation in patients wearing HEMA lenses.
Prevention as a problem of modernity : the example of HIV and AIDS (1995)

Les AA. montrent que la notion de risque est un concept moderne. Ils soulignent que pour certains analystes celle-ci est liee au developpement de la modernite et a une prise en compte du hasard et de l'insecurite. Ils s'interessent aux perceptions du risque dans le domaine medical et plus particulierement a l'evaluation des chances d'etre contamine par le SIDA. Le discours en ce domaine serait revelateur des perceptions du danger et des strategies de gestion des risques. Ils examinent ces structures au niveau individuel, public et medical
Heart failure: state-of-the-art treatment and new therapeutic options. (2003)

Heart failure is one of the most common health problems in Western countries. Untreated, the prognosis is very poor and there is no curative therapeutic approach yet. The gold standard for final stage congestive heart failure (CHF) is still heart transplantation. In recent years the medical therapy of heart failure has improved significantly. But still, beta-blockers, ACE inhibitors and diuretics are not offered to every patient with chronic heart failure. Currently, new therapeutic approaches are being evaluated: immunoadsorption and biventricular pacing. This article summarizes the latest recommendations for medical therapy of heart failure and will explain the mechanisms and clinical results of these new therapeutic options.
Letters (2000)

A project exploring the use of complementary therapies by people with dementia is being undertaken through the Oxford, Bristol and London Dementia Centres, supported by the Mental Health Foundation. The therapies chosen for investigation are massage, aromatherapy, reflexology, herbal medicine, therapeutic touch, reiki and spiritual healing. The researchers would like to hear from practitioners who have experience of the use of the selected therapies by people with dementia.
Indoor wireless LAN access methods for factories (2002)

Access control mechanisms that can be implemented in factories, namely, random access, deterministic access, and polling access methods, are investigated. Based on the parameters for an existing mobile data communications system, the performances of the access protocols are compared in a broad sense and in terms of mean message delay performance. An indoor wireless local area network is a convenient and relatively low-cost method of communicating control information and data to and from mobile robots in a factory automation application. The random access protocols perform better in the low utilization range. The polling and deterministic access protocols perform well in the middle to high utilization range. For direct control of an autonomous robot fleet and applications with a small number of stations, the deterministic access methods prevail under the conditions studied. For a polling system, the response time is strongly dependent on the polling overhead, which is very implementation-dependent.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Abstract B252: The unique mechanism of action of VAL-083 may provide a new treatment option for some chemo-resistant cancers. (2013)

Abstract Poor outcomes in cancer therapy due to chemo-resistance remain a significant unmet clinical problem for many solid tumors and leukemias. VAL-083 (dianhydrogalactitol) represents a structurally unique first-in-class N7-bifunctional DNA alkylating agent. VAL-083 primarily mediates guanine N7 DNA cross-links, which separates it from other DNA alkylating chemotherapeutics (e.g. temozolomide) that have their primary cytotoxicity by targeting DNA at the O6 position of guanine. As expected from its mechanism, VAL-083 overcomes resistance associated with O6-methylguanine-DNA methyltransferase (MGMT) overexpression in vitro. Furthermore, unlike other N7-acting drugs, such as cisplatin which primarily induces intrastrand crosslinks, VAL-083 mediates interstrand DNA crosslinks. When tested side-by-side in a standard syngeneic mouse fibrosarcoma model (RIF-1 cell-line in C3H mice), VAL-083 demonstrated superiority to cisplatin in tumor growth delay. For mice treated with a single injection of cisplatin of 4 mg/kg, the tumor growth delay was 1.45 days compared to untreated controls. Single IP injection of VAL-083 at a dose of 10 mg/kg delayed tumor growth by 5.6 days. Combination treatment of VAL-083 followed immediately by cisplatin produced a more than additive effect by delaying growth 8.65 days. VAL-083 readily crosses the blood-brain barrier, accumulates in brain tissue and is effective against brain tumor cells both in vitro and in vivo, and against brain cancer stem cells in vitro. VAL-083 is currently in Phase I/II clinical trials for glioblastoma and recurrent metastatic brain tumors. Studies are underway to further characterize the efficacy of VAL-083 in various tumor cell-lines resistant to chemotherapy. Previous clinical studies showing VAL-083 activity in several tumor models, combined with the new data on MGMT-chemo-resistance and synergy with cisplatin makes VAL-083 a promising alternative for both primary and secondary brain tumors as well as cisplatin-resistant tumors. Citation Information: Mol Cancer Ther 2013;12(11 Suppl):B252. Citation Format: Anne Steino, Jeffrey A. Bacha, William J. Garner, Sarath Kanekal, Zahid H. Siddik, Dennis M. Brown. The unique mechanism of action of VAL-083 may provide a new treatment option for some chemo-resistant cancers. [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2013 Oct 19-23; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2013;12(11 Suppl):Abstract nr B252.
Sunshine: a high performance self-routing broadband packet switch architecture (2005)

The fiber based broadband network will offer services ranging from circuit emulations where extremely low cell loss rams are essential to high speed variable rate services which can tolerate a degree of cell loss but whose bandwidth requirements may be extremely bursty and unpredictable. This paper presents a high performance self-routing packet switch architecture called Sunshine, that is well suited for this wide range of potential services with their diverse performance objectives and traffic characteristics. Sunshine is based on Batcher/banyan networks and combines both internal and output queuing techniques within a single architecture. Access to the output queues is provided by parallel banyan routing networks which allow multiple cells to be delivered simultaneously to each destination. Excess cells, due to momentary output overloads, overflow into a shared recirculating queue where they are delayed and resubmited as dedicated switch inputs in the following packet slot. A priority structure ensures cefts access each queue based on priority allowing multiple grades of service to coexist within the switch. Results based on extensive simulations which modeled low speed services by a random arrival process, circuit emulations by a periodic arrival process, and high speed variable-rate services by a bursty process show that this architecture can achieve the extremely low cell loss rates necessary for circuit emulations, and is robust in a bursty environment.
Inference of a continuous auto-regressive model for the forecasting of nonstationary stochastic processes deriving from energy demand in electrical networks (2002)

This paper discusses the application of Hilbertian auto regressive models to medium term forecasting of electric energy demand, that is, one week-ahead prediction. These models are aimed at predicting whole future trajectories of continuous stochastic processes and can be useful in order to forecast not only the aggregate figures of energy demand (e.g., mean levels and load peaks), but also the time evolution of electrical quantities. Consideration on the optimum number of weeks which should be employed in order to achieve the minimum-variance prediction as well as on the robustness of the model to particular data and outliers, due, for example, to sudden weather changes, are reported.
The quantum Schur and Clebsch-Gordan transforms: I. efficient qudit circuits (2007)

We present an efficient family of quantum circuits for a fundamental primitive in quantum information theory, the Schur transform. The Schur transform on n d-dimensional quantum systems is a transform between a standard computational basis to a labelling related to the representation theory of the symmetric and unitary groups. If we desire to implement the Schur transform to an accuracy of e-1, then our circuit construction uses a number of gates which is polynomial in n, d and log(e-1). The key tool in our construction is a poly(d, log n, log(e-1)) algorithm for the ud Clebsch-Gordan transform. Our efficient circuit construction renders numerous protocols in quantum information theory computationally tractable and yields a new possible approach to quantum algorithms which is distinct from the standard paradigm of the quantum Fourier transform.
First 4.5-in Through-Tubing ESP with Downhole Wet Connect (2009)

Abstract Artificial Lift Company Ltd. (ALC) and ConocoPhillips Company in 2004 initiated a 5 year development program to have a fully deployed wire-line through tubing electric submersible pump (TTESP) with a down hole 3 phase electrical wet connector. ConocoPhillips Alaska had immediate applications for this technology in its Alaska business unit, West Sak asset. The wells in this asset are multi lateral and suffer from large amounts of sand production which settles in the mother bore restricting production flow to the ESP. Historically, a Rig would be required to pull the tubing and ESP equipment to allow access for wellbore intervention. ConocoPhillips has had 10 years of experience with wireline pumps1 which allowed pump replacement of sanded pumps but did not provide for rigless cleanout of the casing below the ESP. The ability to pull the entire ESP through 4.5" tubing providing an unobstructed tubing string for placement of lateral re-entry modules and to conduct coiled tubing cleanouts of sand in the casing was highly desireable. This was also aligned with ALC's objective which was to make the system compatible with the most common wellbore architecture.
La producció artística de Gaspar Oms a Inca (2000)

Basement membranes in human gingiva are found in dento-epithelial junction, epithelial-connective tissue junction and endothelium-connective-tissue junction where they have important attachment and filtering functions. The ability of plaque and gingiva-derived proteinases to degrade Type IV collagen, the major protein of basement membranes, was examined in vitro. The basement membrane collagen (Type IV) isolated from bovine lens capsules was incubated in the presence of enzyme samples. The degradation was assayed by the release of hydroxyproline from the insoluble substrate and by examining the peptide pattern of the residue by polyacrylamide gel electrophoresis. Salt extracts of inflamed gingival specimens degraded basement membrane collagen into soluble form and produced degradation products that were similar to those produced by human leukocyte extracts. Gingival crevicular fluid collected from patients with severe adult periodontitis also digested the substrate but the degradation pattern was different from the leukocyte and gingival extract samples. The pattern closely resembled the degradation produced by bacterial plaque extracts. A third type of cleavage was observed when collagenase from Clostridium histolyticum was incubated with basement membrane collagen. Crevicular fluid and the extracts from gingiva, leukocytes and plaque also contained gelatinase and elastase-like enzyme activities that have earlier been shown to be potent in degrading basement membrane. It was concluded that enzymes capable of degrading basement membrane collagen in gingivitis and periodontal disease may originate from both plaque bacteria and human leukocytes. It also appeared that the enzymes responsible are more likely to be gelatinase and elastase-like enzymes than specific collagenases.