gebhart/patrepeval huggingface dataset:
Time series analysis on outcomes of tuberculosis control and prevention program between small areas in Korea : with patient (2000)

Backgrounds Today, tuberculosis cannot only be cured medically, but also controlled by public health. Despite the overall worldwide decline in tuberculosis, the disease continues to be a significant problem among developing countries and in the slums of large cities in some industrialized countries. Particularly, this communicable disease has come into the public health spotlight because of its resurgence in the 1990's Our country has been operating the Korean National Tuberculosis Control Program since 1962, focusing around public health centers. Therefore, this study aims to compare the effectiveness of tuberculosis control activities, one of the major public health activities in Korea, by producing indexes, such as the yearly registration rate per 100,000 population and treatment compliance of tuberculosis on in small areas (communities). Methods This work was accomplished by constructing a time-series analytic model using data from "1980~2000 : the Yearly Statistical Report" with patient registry data of 234 City. County. District public health centers and by identifying the factors influencing the tuberculosis indexes. Results The trends of pulmonary tuberculosis positive point prevalence and pulmonary tuberculosis negative point prevalence on X-ray screening have declined steadily, beginning in 1981 and continuing to 1998 by region (city. county. district). Although the tuberculosis mortality rate steadily shows a declining trend by year and region, but Korea still ranks first among 29 OECD countries in 1998, with a tuberculosis mortality rate of 7.1 per 100,000 persons, according to the time-series analysis for fatal diseases. Conclusion The results of the study will form the fundamental basis of future health care planning and the Korean Tuberculosis Surveillance System on 2000. Since the implementation of local autonomy through the Local Health Act of 1995. it has now become vital for each city. county. district public health centers to determine its own priorities for relevant health care management, including budget allocation and program goals.
Coded Stepped-FMCW Signal for Automotive Collision Warning Radar Applications (2001)

This paper describes a new transmit signal for millimeter wave automotive collision warning radar applications. The signal provides high range resolution and has good anti-interference capabilities. The paper also presents a trial and error approach algorithm for detecting multi-targets as well as eliminating false targets.
Type II estrogen binding sites and antiproliferative activity of quercetin in human meningiomas (1993)

Eleven cases of meningiomas were investigated for the presence of estrogen and progesterone receptors. These tumors specifically bound estradiol. This binding activity almost exclusively resulted from the presence of high numbers of type II estrogen binding sites (EBS). Estrogen receptors were absent or present at low concentrations. Competition analysis showed that the flavonoid, quercetin, competed for tritiated estradiol binding to type II EBS; both rutin and hesperidin did not. In addition, 10 microM quercetin, unlike rutin or hesperidin, was effective in inhibiting in vitro bromodeoxyuridine incorporation by meningioma cells. Although the mechanism of the antiproliferative activity of quercetin remains to be clarified, it is possible that this flavonoid may regulate cell growth through a ligand interaction with type II EBS.
Accurate multiplexing and filtering for high-throughput amplicon-sequencing (2015)

Tagging amplicons with tag sequences appended to PCR primers allow the multiplexing of numerous samples for high-throughput sequencing (HTS). This approach is routinely used in HTS-based diversity analyses, especially in microbial ecology and biomedical diagnostics. However, amplicon library preparation is subject to pervasive sample sequence cross-contaminations as a result of tag switching events referred to as mistagging. Here, we sequenced seven amplicon libraries prepared using various multiplexing designs in order to measure the magnitude of this phenomenon and its impact on diversity analyses. Up to 28.2% of the unique sequences correspond to undetectable (critical) mistags in single- or saturated double-tagging libraries. We show the advantage of multiplexing samples following Latin Square Designs in order to optimize the detection of mistags and maximize the information on their distribution across samples. We use this information in designs incorporating PCR replicates to filter the critical mistags and to recover the exact composition of mock community samples. Being parameter-free and data-driven, our approach can provide more accurate and reproducible HTS data sets, improving the reliability of their interpretations.
Pentosan Polysulfate Decreases Myocardial Expression of the Extracellular Matrix Enzyme ADAMTS4 and Improves Cardiac Function In Vivo in Rats Subjected to Pressure Overload by Aortic Banding (2014)

We hypothesized that cleavage of the extracellular matrix (ECM) proteoglycans versican and aggrecan by ADAMTS (a disintegrin and metalloprotease with thrombospondin motifs) proteases, which contributes to stress-induced ECM-reorganization in atherogenesis and osteoarthritis, also play a role in heart failure development.
Enhanced exon skipping and prolonged dystrophin restoration achieved by TfR1-targeted delivery of antisense oligonucleotide using FORCE conjugation in <i>mdx</i> mice (2022)

Current therapies for Duchenne muscular dystrophy (DMD) use phosphorodiamidate morpholino oligomers (PMO) to induce exon skipping in the dystrophin pre-mRNA, enabling the translation of a shortened but functional dystrophin protein. This strategy has been hampered by insufficient delivery of PMO to cardiac and skeletal muscle. To overcome these limitations, we developed the FORCETM platform consisting of an antigen-binding fragment, which binds the transferrin receptor 1, conjugated to an oligonucleotide. We demonstrate that a single dose of the mouse-specific FORCE-M23D conjugate enhances muscle delivery of exon skipping PMO (M23D) in mdx mice, achieving dose-dependent and robust exon skipping and durable dystrophin restoration. FORCE-M23D-induced dystrophin expression reached peaks of 51%, 72%, 62%, 90% and 77%, of wild-type levels in quadriceps, tibialis anterior, gastrocnemius, diaphragm, and heart, respectively, with a single 30 mg/kg PMO-equivalent dose. The shortened dystrophin localized to the sarcolemma, indicating expression of a functional protein. Conversely, a single 30 mg/kg dose of unconjugated M23D displayed poor muscle delivery resulting in marginal levels of exon skipping and dystrophin expression. Importantly, FORCE-M23D treatment resulted in improved functional outcomes compared with administration of unconjugated M23D. Our results suggest that FORCE conjugates are a potentially effective approach for the treatment of DMD.
Computer structures (1998)

Article Free Access Share on Computer structures: what have we learned from the PDP-11? Authors: Gordon Bell View Profile , William D. Strecker View Profile Authors Info & Claims ISCA '98: 25 years of the international symposia on Computer architecture (selected papers)August 1998Pages 138–151https://doi.org/10.1145/285930.285974Published:01 August 1998Publication History 1citation437DownloadsMetricsTotal Citations1Total Downloads437Last 12 Months27Last 6 weeks2 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Publisher SiteeReaderPDF
A Concise Approach to the Dalesconol Skeleton (2011)

A rapid approach to the skeleton of dalesconol A and B, unprecedented immunosuppressants, has been achieved through a convergent strategy featuring a carbocation-mediated dearomatization–cyclization and a following one-pot consecutive operation.
Routing in mobile ad hoc networks (2003)

This paper describes a simulation-based evaluation of several unicast routing protocols tailored specifically for mobile ad hoc networks. Four protocols were evaluated: the wireless Internet routing protocol (WIRP), a link state (LS) algorithm with constrained LS updates, a distance vector variant of WIRP, and temporally ordered routing algorithm (TORA). The goal was to determine how well these routing protocols worked in specific tactical conditions, supporting a given mix of traffic. Factors varied included tactical scenario, network size, and loading. Tactical scenario included different connectivities (e.g., "dense" versus "sparse") and link fluctuation rates (e.g., "high" versus "low"). Metrics collected included average end-to end delay per application, path length, total efficiency, and fraction of user messages received. We found that certain protocols performed better in densely connected networks than in sparser networks (e.g., TORA), while some performed better in sparser networks (e.g., LS). One protocol, WIRP, performed well in both types of networks over the scenarios evaluated, Several remaining issues and areas for continued research are identified.
Low dimensional silicon for integrated optoelectronics (2002)

In contrast to bulk silicon, which is an indirect gap semiconductor, with very low efficiency in radiation emission, low dimensional silicon structures (quantum dots or wires) can emit light with very high efficiency at room temperature. The best known form of low dimensional silicon is porous silicon but other materials of low dimensional silicon, in the form of nanocrystallites or nanowires within insulating matrices, can be fabricated. Their application in silicon based optoelectronics is a challenging one. In this respect, both materials and fabrication techniques need to be compatible with the existing silicon technology. In this paper, the fabrication and properties of low dimensional silicon (nanowires in the form of silicon nanopillars on bulk crystalline silicon and nanocrystallites deposited on thin SiO/sub 2/ layers) will be discussed.
X-ray absorption spectroscopy study of the local structures of crystalline Zn–In–Sn oxide thin films (2009)

The local structure of a Zn, Sn codoped In2O3 thin film grown on ĉ-plane sapphire by pulsed-laser deposition was examined by polarization-dependent x-ray absorption spectroscopy. The bixbyite film structure is both out-of-plane and in-plane oriented, and the structural results show that both Zn and Sn dopants occupy In sites. The In–O bond length is comparable to that in powder In2O3. However, both Sn–O and Zn–O bonds have two distinct distances in the first shell. Some of the Zn dopants are undercoordinated and, accordingly, some isovalent Sn dopants are overcoordinated for charge balance. In addition, the results suggest that the aliovalent Sn dopants form Frank–Köstlin clusters, (2SnIn•Oi″)x, which provide enough charge carriers to explain the Hall measurements.
Nanostructure and Mechanical Properties of Polybutylacrylate Filled with Grafted Silica Particles (2006)

We investigate the nanostructure and the linear rheological properties of polybutylacrylate (PBA) filled with Stöber silica particles grafted with PBA chains. The silica volume fractions range from 1.8 to 4.7%. The nanostructure of these suspensions is investigated by small-angle neutron scattering (SANS), and we determine their spectromechanical behavior in the linear region. SANS measurements performed on low volume fraction composites show that the grafted silica particles are spherical, slightly polydisperse, and do not form aggregates during the synthesis process. These composites thus constitute model filled polymers. The rheological results show that introducing grafted silica particles in a polymer matrix results in the appearance of a secondary process at low frequency: for the lowest volume fractions, we observe a secondary relaxation that we attribute to the diffusion of the particles in the polymeric matrix. By increasing the silica volume fraction up to a critical value, we obtain gellike behavior at low frequency as well as the appearance of a structure factor on the scattering intensity curves obtained by SANS. Further increasing the silica particle concentration leads to composites exhibiting solidlike low-frequency behavior and to an enhanced structure peak on the SANS diagrams. This quantitative correlation between the progressive appearance of a solidlike rheological behavior, on one hand, and a structure factor, on the other hand, supports the idea that the viscoelastic behavior of filled polymers is governed by the spatial organization of the fillers in the matrix.
Hierarchical Routing Architecture (HRA) (2008)

Some recent research activities from IETF and IRTF Routing Research Group (RRG) are to explore a new routing and addressing architecture to meet those challenges that current Internet are facing, especially in scalability. An identifier/locator split idea has been widely recognized as an architectural solution to the routing scalability issue. This paper describes a new routing and addressing architecture, called as Hierarchical Routing Architecture (HRA). HRA is also a kind of id/locator split solution. It introduces a hierarchical and cryptographic host identifier and adopts a hierarchical routing mechanism to support routing across multiple independent address spaces.
7-Alkoxy-4-phenylamino-3-quinolinecar-bonitriles as Dual Inhibitors of Src and Abl Kinases (2004)

We previously reported that several 7-alkoxy-4-phenylamino-3-quinolinecarbonitriles were potent inhibitors of Src kinase activity. We disclose here a new highly efficient and versatile route to these compounds, which are also potent inhibitors of Abl kinase.
BUCS - a bottom-up cache structure for networked storage servers (2004)

This paper introduces a new caching structure to improve server performance by minimizing data traffic over the system bus. The idea is to form a bottom-up caching hierarchy in a networked storage server. The bottom level cache is located on an embedded controller that is a combination of a network interface card (NIC) and a storage host bus adapter (HBA). Storage data coming from or going to a network are cached at this bottom level cache and meta-data related to these data are passed to the host for processing. When cached data exceed the capacity of the bottom level cache, some data are moved to the host RAM that is usually larger than the bottom level cache. This new cache hierarchy is referred to as bottom-up cache structure (BUGS) in contrast to a traditional CPU-centric top-down cache where the top-level cache is the smallest and fastest, and the lower in the hierarchy the larger and slower the cache. Such data caching at the controller level dramatically reduces bus traffic and leads to great performance improvement for networked storages. We have implemented a proof-of-concept prototype using Intel's IQ80310 reference board and Linux network block device. Through performance measurements on the prototype implementation, we observed up to 3 times performance improvement of BUCS over traditional systems in terms of response time and system throughput.
Multiscale Regularization of Flooding Optimization for Smart Field Management (2008)

Summary Smart fields can provide enhanced oil recovery through the combined use of optimization and data assimilation. In this paper, we focus on the dynamic optimization of injection and production rates during waterflooding. In particular, we use optimal control theory in order to find an optimal well management strategy over the life of the reservoir that maximizes an objective function (e.g., recovery or net present value). Optimal control requires the determination of a potentially large number of (groups of) well rates for a potentially large number of time periods. However, the optimal number of well groups and time steps is not known a priori. Moreover, taking these numbers too large can slow down the optimization process and increase the chance of achieving a suboptimal solution. We investigate the use of multiscale regulariza-tion methods to achieve grouping of the control settings of the wells in both space and time. Starting out with a very coarse grouping, the resolution is subsequently refined during the optimization. The regularization is adaptive in that the multiscale parameterization is chosen based on the gradients of the objective function. Results for the numerical examples studied indicate that the regularization may lead to significantly simpler optimum strategies, while resulting in a better or similar cumulative oil production.
Polysaccharides of Soybean Seeds (1965)

A polysaccharide fraction extracted from soybean seeds with boiling water was examined by several fractionation methods on ultracentrifugal criteria. Four components were found by a column chromatography using TEAE-cellulose or by a paper electrophoresis. Acetone-precipitation, fractionation by conversion into acetyl derivative, and copper-complex-precipitation were unsatisfactory to fractionate into the components. The major component (70%) isolated was an arabinogalactan containing residues of arabinose and galactose in the approximate proportion of 1 : 2 and having molecular weight of 3.3×105.
Recirculating Planar Magnetrons for High-Power High-Frequency Radiation Generation (2011)

We present designs and simulations of a new class of magnetron, the recirculating planar magnetron. This magnetron has numerous advantages as a high-power microwave generator, including larger cathode and anode area, fast start-up, and compact microwave extraction geometry. The following two geometries are demonstrated by electromagnetic particle-in-cell codes: 1) axial magnetic field with radial electric field and 2) radial magnetic field with axial electric field.
Anther and microspore cultures of barley and wheat (1997)

This paper briefly cites the various procedures for the production of doubled haploids in barley and wheat. Various associated terms are defined and the factor involved in haploid production are outlined. Isolated microspore cultures offer some advantages over anther culture. Our current procedures for isolated microspore culture of barley and wheat are presented and compared.
Are the Emotions Expressed in Music Genre-specific? An Audio-based Evaluation of Datasets Spanning Classical, Film, Pop and Mixed Genres (2011)

Empirical studies of emotions in music have described therole of individual musical features in recognizing particular emotions. However, no attempts have been made as yet to establish if there is a link between particular emotions and a specific genre. Here this is investigated byanalysing nine separate datasets that represent categories ranging from classical (three sets), and film music (two), to popular music (two), and mixed genre (two). Atotal of 39 musical features were extracted from the audio. Models were then constructed from theseto explain self-reports of valence and arousal, by using multiple andRandom Forest regression. The models were fully validated across the datasets, suggesting low generalizability between the genres for valence (16% variance was accounted for) and moderately good generalizability between the genres for arousal (43%). In contrast, the generalizability within genres was considerably higher (43% and 62% respectively), which suggests that emotions, especially those that express valence, operate differently depending on the musical genre. The most reliable musical features of affects across genres were identified, yielding aranked set of features most likely to operate across the genre. In conclusion, the implications of the findings, and the genre-specificity of emotions in music are discussed.
Effective thermal conductivity of sintered metal fibers (1991)

For the effective thermal conductivity of dry and fluid-saturated sintered metal fibers, existing correlations are compared to experimental data, and a new empirical expression that compensates for the effect of the aspect ratio of the fibers is presented. It is shown that the present equation predicts the data with 10% deviation, while the Acton equation, which has been recommended in some references, has approximately 200% error.
An overview of standing roof support practices and developments in the United States (2005)

2.1 ABSTRACT Many of the support concepts currently used in the United States originated in South Africa. These products include the Hercules Crib 1 , Propsetter, MX Prop, Rocprop, and Spider Prop. Another recent development has been the introduction of hydraulic prestressing units, such as the Jackpot system, to various U.S. standing support systems. Several other prop-type supports with similarities to systems used in South Africa are in use in U.S. coal mines. Some exciting new developments that improve the installation and yield performance of props are also underway. In addition to prop-type supports, crib-type supports and single-unit systems such as the Can support are also frequently utilized in longwall tailgates in the U.S. The goal in U.S. support development is to enhance roof support capability while alleviating material handling barriers to reduce injuries associated with support handling and installation. Support products are generally full-scale tested at the National Institute for Occupational Safety and Health (NIOSH) in the unique Mine Roof Simulator load frame. The performance testing protocol is designed to simulate the full range of load conditions that occur in underground mining to identify the performance deficiencies and limitations of the support products. Once the products complete the performance evaluation, they are implemented into the NIOSH Support Technology Optimization Program (STOP). STOP is a window’s based software program that was developed by NIOSH for facilitating the design of standing roof support systems. STOP has become an industry standard to compare the performance capabilities and facilitate the application of these support products into various mining conditions. The purpose of this paper is to provide an overview of the support design and application philosophy in the United States.
Enthalpy - Improved Dielectric Insulation for Superconducting Wires. (1982)

Abstract : The purpose of this study was to investigate for the first time dielectric materials for enthalpy stabilization, the broad picture being that these materials would also serve as the dielectric-insulation coating. These new, inorganic materials resulted from basic research by the author into the specific heats of ferroelectric-type materials at low and glass which leads to enhanced specific-heat properties in several cases. In a particularly noteworthy case (60% SC-1C ceramic + 40% 7570 glass), the composite has a much larger specific heat (approx. = 0.07 J/cu cm/K) than the bulk ceramic alone below 7 K. There is evidence that the low thermal conductivities of all the composites are due to Kapitza resistance, and suggestions are made for improving these conductivities.
Evaluation of cycloolefin-maleic anhydride alternating copolymers as single-layer photoresists for 193-nm photolithography (1996)

We have developed a fundamentally new class of photoresist matrix resins for use in 193 and 248 nm lithography based on cycloolefin-maleic anhydride alternating copolymers. When used in three-component formulations with cholate-based dissolution inhibitions (DIs) and conventional photoacid generators, these copolymers afford positive-tone resists with potential sub-0.25 micrometer image fidelity. The resists exhibit high contrast (3 - 5.5) and high sensitivity (3 - 5 mJ/cm<SUP>2</SUP> at 248 nm, depending on exact formulation) with low loadings (ca. 1 wt%) of triphenylsulfonium salt photoacid generators. These formulations are sufficiently transparent to be used at 193 nm without further modification.