gebhart/patrepeval huggingface dataset:
PP.29.12 (2015)

Objective: Traditional Chinese Medicine Constitution (TCMC) theory is widely applied in the practice of medical treatment for thousand years in China, which is identified as the treasure of Chinese civilization. TCMC determined the susceptibility to certain disease and therapy effect, which can be divided into normal constitution and unbalanced ones. This study aims at investigating the distribution and the characteristic of TCMCs in adult Chinese resident in Changsha and the effects on susceptibility and therapy effect of hypertension. Design and method: The study used cross-sectional survey, collected all available information which including age, gender, occupation, alcohal/smoke intake, familiy history, body mass index (BMI), blood pressure (BP), TCMC and blood test in part respondents from community healthy registry system in Yuelu district, Changsha city. The association between independent factors and each TCMCs, as well as TCMCs and the prevalence and control rate were analysed. Prediction prevalence model of hypertension were established by Logistic analysis with TCMC and other factors. Results: A total of 237,485 individual records were collected, of which 186,775 (78.6%) were balanced TCMC. Statistical analysis indicated that age, BMI, occupation, smoking and alcohol intake, hemoglobin, fasting blood-glucose, cholesterol, triglyceride, creatinine, potassium and sodium in blood were different in balance and unbalance TCMCs groups. The prevalence of hypertension was significant difference between balance and unbalance TCMCs groups (9.3% vs 30.7%, P < 0.01). Yin-deficiency (48.9%), Blood stasis (36.8%) and Qi-deficiency (34.4%) were more likely to suffering from hypertension. Logistic analysis indicated age, sex, BMI, alcohol, smoke, family history and TCMCs were significant correlated the prevalence of hypertension. 29,123 (88.2%) hypertensive patients were under administrated by community physician. Blood pressure was significant higher in unbalance TCMCs group compared with balance TCMCs group in both systolic and diastolic blood pressure (SBP/DBP) (133.91 ± 14.79 vs 132.62 ± 15.07mmHg, P < 0.01;80.51 ± 9.03 vs 80.27 ± 8.90mmHg, P < 0.05).Wetness-heat had the worst SBP/DBP control level, while Yin-deficiency had the best SBP/DBP control level. Conclusions: Age, occupation, smoking and alcohol intake, BMI, blood glucose/lipid metabolism, hemoglobin, blood electrolytes may contribute the formation of TCMCs. TCMCs have an impact on incidence and therapy effect of hypertension, could be a potential subtyping for hypertension.
Yeast Retrotransposon Particles as Antigen Delivery Systems (1995)

The development of technologies to produce recombinant proteins for use in the pharmaceutical industry has made substantial advances, in particular in the area of generating antigens containing multiple copies of important immunological regions. One such antigen-carrier system is based on the ability of a protein encoded by the yeast retrotransposon, Ty, to self-assemble into virus-like particles. Ty-fusion proteins retain this ability to form particles, and a range of hybrid VLPs carrying a variety of heterologous antigens have been produced and shown to induce potent immune responses. In particular, hybrid VLPs carrying the core protein p24 of HIV (p24-VLPs) have been shown to induce antibody and T-cell proliferative responses in both experimental animals and human volunteers, and immunization of rabbits with VLPs carrying the principal neutralizing determinant of HIV (V3-VLPs) resulted in the induction of neutralizing antibody responses and T-cell proliferation. Further studies with V3-VLPs have shown that this particulate antigen stimulates enhanced V3-specific lymphoproliferative responses as compared to whole recombinant gp120 or to V3 peptide conjugated to albumin. The V3-VLPs also induce potent CTL responses following immunization of mice in the absence of adjuvant. These responses are MHC class I restricted and are mediated by CD8-positive cells. These observations therefore demonstrate that hybrid Ty-VLPs induce both humoral and cellular immune responses against HIV and suggest that these immunogens may be important in combatting AIDS and other infections.
The Curious Case of Combining Text and Visualization (2019)

Visualization research has made significant progress in demonstrating the value of graphical data representation. Even still, the value added by static visualization is disputed in some areas. When presenting Bayesian reasoning information, for example, some studies suggest that combining text and visualizations could have an interactive effect. In this paper, we use eye tracking to compare how people extract information from text and visualization. Using a Bayesian reasoning problem as a test bed, we provide evidence that visualization makes it easier to identify critical information, but that once identified as critical, information is more easily extracted from the text. These tendencies persist even when text and visualization are presented together, indicating that users do not integrate information well across the two representation types. We discuss these findings and argue that effective representations should consider the ease of both information identification and extraction.
Chatter Vibration of Lathe Tools (1956)

Abstract This paper deals with a chatter vibration which occurs frequently when metals are being machined. It has been ascertained experimentally that the chatter is a self-excited vibration caused by the lag in fluctuation taking place in the horizontal cutting force behind the horizontal vibration of the work. Because of this delay in cutting force, it has been proved that the chatter may be expressed in terms of a difference-differential equation.
Macromol. Biosci. 1/2012 (2012)

Cover: The cover features the first demonstration of interfacing the living yeast cells with graphene nanosheath. The versatile layer-by-layer assembly will allow the potential of integrating new physical and chemical functions for living cells while preserving their viability. Further details can be found in the article by S. H. Yang, T. Lee, E. Seo, E. H. Ko, I. S. Choi,* and B.-S. Kim* on page 61.
Anterior cruciate ligament injury patterns among collegiate men and women. (1999)

Although the higher rate at which women compared with men tear their ACLs has persisted over the last 10 years, this increased incidence is not clearly attributable to any physical or historical measurements that were monitored.
Increased cAMP and cAMP-Dependent Protein Kinase Activity Mediate Anti-CD2 Induced Suppression of Anti-CD3-Driven lnterleukin-2 Production and CD25 Expression (1995)

Anti-CD2 monoclonal antibody (mAb) can act synergistically with anti-CD3 to produce tolerance and diminish the anti-CD3-induced cytokine syndrome. Since interleukin(IL)-2 production and IL-2 receptor (IL-2R; CD25) expression are important determinants of CD3-driven T cell activation, the effects of anti-CD2 on anti-CD3-induced CD25 expression and IL-2 production were analyzed and related mechanistically to CD2-stimulated cAMP signaling with an in vitro model of T cell activation. The anti-CD2 mAb, 12-15, alone had no effect on splenic T cell CD25 expression and IL-2 production, while the anti-CD3 mAb, 145-2C11, caused significant increases in both CD25 expression and IL-2 production. The addition of anti-CD2 inhibited anti-CD3-induced increases in CD25 and IL-2. The inhibitory signal delivered by anti-CD2 was effective in many forms of T cell activation, since other stimuli which increased CD25, such as concanavalin A, phytohemagglutinin, and Staphylococcal enterotoxin B (SEB), could also be inhibited by anti-CD2. The inhibitory effect of anti-CD2 on CD25 could not be reversed by high doses of supplemental IL-2 added to the culture. Anti-CD2 increased cytoplasmic cAMP in a dose- and time-dependent manner. Reagents that increased cytoplasmic cAMP such as forskolin, cholera toxin, and 3'-isobutyl-1-methylxanthine could mimic the inhibitory effect of anti-CD2 on anti-CD3-driven CD25 expression. Anti-CD2 also increased the activity of cAMP-dependent protein kinase (PKA). H8, a PKA antagonist, blocked the inhibitory effect of anti-CD2 on CD25 expression, further confirming the role of PKA in CD2-induced negative signaling. The use of paired agonists to PKA demonstrated that a type I PKA was the preferential enzyme isoform stimulated by CD2 ligation. These findings show that increased cAMP and PKA activity mediate anti-CD2-induced suppression of anti-CD3-driven IL-2 production and CD25 expression, and provide mechanisms for anti-CD2-induced immunosuppression and inhibition of the cytokine syndrome associated with anti-CD3 treatment.
Abstract: Niko Resources Canada — an India Success Story (2003)

Abstract One of the first foreign companies to enter the post 1990 India E&P arena was Niko Resources from Canada. Since 1994 the company has achieved much success by aggressively pursuing a balanced growth strategy focused on gas prospects in India. Niko Resources founder and President, Robert Ohlson, signed Production Sharing Contracts for five Blocks in the State of Gujarat in 1994 including Hazira. The Hazira # 1 well drilled in 1969 was reworked and put on production at 6 MMcf/d in mid 1995. A total of 21 wells have been drilled at Hazira including 14 on a land based drilling platform that stretches 1.5 kilometres into the ocean. Field production at the end of December was approximately 110 MMcf/d and reserves estimated at greater than 700 Bcf in-place. An offshore platform will be installed at the end of 2003 and subsequent drilling will add 150 MMcf/d of gas production. Niko has a 10% working interest in 2 blocks located off the east coast of India. On Block KG-DWN-98/3 the consortium has acquired an 1822 square kms 3D seismic survey and drilled 5 wells with a 100% success rate that has resulted in 2 major gas discoveries. The operator of the block estimates gas in-place in excess of 7 trillion cubic feet on the first discovery. The second discovery is currently being evaluated with further drilling. A 1,795 square km 3D seismic program has been acquired on Block, NEC-OSN-97/2 and the first well is planned for mid 2003. In July 2001, Niko was awarded a 100% interest in the onshore Surat Block, located 8 kilometres NE of the company operated Hazira gas field. Within 11 months of contract award Niko had completed 330 square kms of 3D, 113 km of 2D and initiated a 15 well drilling program. The first gas discovery was made in June 2002 and first production is planned in April 2003. Niko continues to pursue and grow a balanced portfolio of prospects throughout the South Asian area, concentrating primarily on the Indian subcontinent. Presented at: 2005 South East Asia Petroleum Exploration Society (SEAPEX) Conference, Singapore, 2003
A new scheme of a lensed fiber employing a wedge-shaped graded-index fiber tip for the coupling between high-power laser diodes and single-mode fibers (2001)

A novel lensed fiber employing a wedge-shaped graded-index fiber (GIF) is proposed. The characteristic of coupling loss as a function of the aspect ratio is numerically investigated. When the aspect ratio is seven, the coupling loss of a wedge-shaped GIF and a conventional wedge-shaped SMF are 0.22 dB and 0.60 dB, respectively, and when the aspect ratio is 13, they are 0.5 dB and 2.4 dB. The tolerance to laser diode (LD)-fiber displacement is also numerically investigated, and it is confirmed that the proposed fiber has larger tolerance than a conventional wedge-shaped single-mode fiber (SMF). The performance of the new lensed fiber is also experimentally verified.
Eukaryotic mono(ADP-ribosyl)transferase that ADP-ribosylates GTP-binding regulatory Gi protein. (1988)

An NAD:cysteine ADP-ribosyltransferase designated ADP-ribosyltransferase C was purified approximately 35,000-fold from human erythrocytes with an 11% yield. The purified ADP-ribosyltransferase C exhibited one predominant protein band on sodium dodecyl sulfate-polyacrylamide gels with an estimated molecular weight (Mr) of 28,500. The Km values for NAD and cysteine methyl ester were determined to be 65 and 4,400 microM, respectively. By using human erythrocyte inside-out membrane vesicles, the transferase C was found to ADP-ribosylate the alpha subunit (Mr = 41,000) of Gi, which is a substrate for pertussis toxin. The ADP-ribosylation of Gi alpha catalyzed by ADP-ribosyltransferase C was inhibited by pre-ADP-ribosylation with pertussis toxin. The linkage of ADP-ribose-Gi alpha in the membranes formed by ADP-ribosyltransferase C was as stable to hydroxylamine as that formed by pertussis toxin. These data represent the first demonstration that eukaryotic cells contain an ADP-ribosyltransferase which can catalyze the ADP-ribosylation of a cysteine residue in Gi alpha.
Growth and Glucose Repression Are Controlled by Glucose Transport in <i>Saccharomyces cerevisiae</i> Cells Containing Only One Glucose Transporter (1999)

A set of Saccharomyces cerevisiae strains with variable expression of only the high-affinity Hxt7 glucose transporter was constructed by partial deletion of the HXT7 promoter in vitro and integration of the gene at various copy numbers into the genome of an hxt1-7 gal2 deletion strain. The glucose transport capacity increased in strains with higher levels of HXT7 expression. The consequences for various physiological properties of varying the glucose transport capacity were examined. The control coefficient of glucose transport with respect to growth rate was 0.54. At high extracellular glucose concentrations, both invertase activity and the rate of oxidative glucose metabolism increased manyfold with decreasing glucose transport capacity, which is indicative of release from glucose repression. These results suggest that the intracellular glucose concentration produces the signal for glucose repression.
Immunogenic Variation between Multiple HLA-A*0201-Restricted, Hepatitis C Virus-Derived Epitopes for Cytotoxic T Lymphocytes (2006)

CD8+ cytotoxic T lymphocytes (CTLs) play a critical role in the immune control of Hepatitis C Virus (HCV) infection. In the current study, a number of HLA-A*0201-restricted CTL epitopes derived from HCV were evaluated by examining the peptide-binding affinity for major histocompatibility complex (MHC) class I molecules, the stability of peptide-MHC complexes, killing activities of peptide-induced CTLs, and frequencies of intracellular interferon (IFN)-gamma-positive CD8+ T cells. Among 24 peptides tested, 15 peptides induced high or medium killing activities of peptide-specific CTLs. Thirteen of the 15 peptides exhibited high or medium binding affinities for HLA-A*0201 molecules, indicating that the high binding affinity for MHC class I molecules is an important factor for immunogenicity. In contrast, the stability of peptide-MHC class I complexes was not correlated with killing activities of peptide-induced CTLs. Furthermore, only a limited number of peptides could induce high or medium frequencies of IFN-gamma-producing CD8+ T cells, which were generally considered to play a crucial role for the clearance of HCV. Analyses of the immunogenicity of CTL epitopes such as in the current study should provide important information about the design of an efficient HCV vaccine that induces vigorous, sustained, and broad HCV-specific CTL responses.
New pattern on fabrication of fiber spinnerets by LIGA technology (1999)

In the past, the capillaries of fiber-spinneret were made by drilling or by micro electro-discharge-machining. In this study a new process for manufacturing a spinneret die was developed. LIGA process provides the new method of capillary manufacturing. The diameter of the capillaries is 200 micrometers . and L/D ratio is 3. The stability during fiber spinning can be improved by using capillaries with higher aspect ratio. Details on micro-injection mold design, analysis, manufacturing and process conditions will be discussed. Better process conditions will be introduce through experiment design technology. Through single injection molding process, a 48-capillaries structure was formed. The diameter of each capillary was inspected along longitudinal direction carefully. The result shows that the accuracy of the diameter for each capillary can be controlled to be 200 +/- 1 micrometers range. Capillaries to spin w-shaped micro- fibers were also developed in this work. The width in each capillary is 100 micrometers with higher aspect ratio up to 16. With consequent treatments and electro-forming, the spinneret can be produced in the mass production way. A real metal spinneret die was electro-formed in this study. The technology developed here can also be used in the fabrication of MEMS components.
Influence of L-carnitine on litter characteristics from gilts harvested at day 40, 55, and 70 of gestation (2005)

A total of 59 gilts were used to determine the effects of supplemental L-carnitine on reproductive performance. Experimental treatments were arranged in a 2 Ã— 3 factorial with main effects of L-carnitine (0 or 50 ppm) and day of gestation (40, 55, or 70). All gilts received a constant feed allowance of 3.86 lb/day and a top-dress containing either 0 or 88 mg of L-carnitine, starting on the first day of breeding and continuing until the day of harvest. Total litter size, total litter weight, and crown-to-rump length of fetuses were not different (P>0.10) between treatments at any gestation length. By d 70 of gestation, average fetus weight was heavier (P = 0.06) for fetuses from gilts fed L-carnitine, compared with fetuses from gilts fed the control diet. In addition, at d 70, fetal insulin-like growth factor- II (IGF-II) concentrations were lower (P = 0.09) for fetuses from gilts fed L-carnitine than for fetuses from gilts fed the control diet. Feeding L-carnitine may have decreased fetal IGF-II, therefore increasing cell proliferation and delaying cell differentiation. These results show that providing supplemental Lcarnitine to gestating gilts has beneficial effects on average fetal weight, possibly observed because of its ability to reduce fetal IGF-II concentrations.; Swine Day, 2005, Kansas State University, Manhattan, KS, 2005
Polyphenolic Constituent Structures of<i>Zanthoxylum piperitum</i>Fruit and the Antibacterial Effects of Its Polymeric Procyanidin on Methicillin-Resistant<i>Staphylococcus aureus</i> (2006)

Zanthoxylum piperitum (Rutaceae) is used as a spice and a natural medicine in Japan. Our study found that ZP-CT-A, a polymeric proanthocyanidin purified from the fruit of this species, noticeably decreased the minimum inhibitory concentrations of beta-lactam antibiotics for methicillin-resistant Staphylococcus aureus (MRSA). The structure of ZP-CT-A was characterized on the basis of (13)C NMR and size exclusion chromatographic data and the results of thiolytic degradation. A mechanistic study of the effects of ZP-CT-A indicated that it suppressed the activity of beta-lactamase and largely decreased the stability of the bacterial cell membrane of MRSA, as shown by a reduction in the tolerance of MRSA to low osmotic pressure and high ionic strength solutions.
Improvement in the Luminescence Properties and Processability of LaF<sub>3</sub>/Ln and LaPO<sub>4</sub>/Ln Nanoparticles by Surface Modification (2004)

The surface of lanthanide(III)-doped LaPO4 nanoparticles was modified by reaction with an alcohol, leading to a covalent bond between the ligand and the particle surface. The surface of lanthanide(III)-doped LaF3 nanoparticles was modified to alter the solubility of the nanoparticles and study the influence of surface effects on the luminescence of lanthanide ions doped in the nanoparticles. The coordinated organic ligands can be modified by a quantitative exchange reaction in solution or by using functionalized ligands during the synthesis. Variation of the ratio of ligand to core reagents had a significant influence on the size of the nanoparticles. Smaller nanoparticles were formed with a higher ligand ratio. The optical properties of these nanoparticles show a strong dependence on nanoparticle size, indicating the influence of quenching probably by CH and OH groups at or near the surface of the nanoparticle cores. The luminescence lifetime of LaF3/Eu nanoparticles varied from 6.5 to 7.4 ms for nanoparticles with an average size of 7.1 to 8.4 nm. A significant reduction of the quenching from the surface of the nanoparticles was obtained by the synthesis of core-shell nanoparticles, in which a shell of LaF3 was grown epitaxially around the doped core nanoparticles. This leads to an increase in the luminescence lifetime of the Eu3+ ion and the observation of emissions from the 5D2 energy level, in addition to emissions from the 5D1 and 5D0 levels. The quantum yield of LaF3/Ce,Tb nanoparticles could be increased from 24 to 54% by the growth of a LaF3 shell around the nanoparticles.
Design of a 1 V 250 MHz current-mode filter in conventional CMOS process (2002)

The design of a 1 V 250 MHz 8th-order continuous-time current mode filter with on-chip automatic digital frequency tuning is presented. The low voltage filter is realized using simple current amplifiers and cascade connection of current mode Sallen-Key biquads, whose configuration is modified to achieve Q switching between finite and infinite independent on the filter pole frequency for tuning. The frequency response tuning is achieved by using programmable capacitor arrays and digital tuning methods. The IM3 was simulated to be -52.5 dB for a 200 MHz and 250 MHz two-tone signal with a 300 mV p-p voltage. Simulations show frequency tuning range between 237 MHz and 325 MHz in conjunction with low power consumption (less than 27 mW) for a 1 V supply.
Semiparametric econometrics: A survey (1988)

Abstract Semiparametric econometric models contain both parametric and nonparametric components, reflecting in some fashion what has been learned from economic theory and previous empirical experience, and what remains unknown. They raise such questions as how well the parametric component can be estimated, and how to construct rules of inference with good statistical properties. The paper attempts to survey the econometric and most relevant statistical literature on semiparametric inference, and includes a partial bibliography.
Selective ionization of Ba and Sr isotopes based on a two-photon interference effect (1990)

We show that the zero- and nonzero-nuclear-spin isotopes of Ba and Sr can be excited and ionized at different rates by sequential absorption of radiation from two pulsed laser beams. The selective excitation takes place in a J=0\ensuremath{\leftarrow}J=1\ensuremath{\leftarrow}J=0 energy-level scheme (where J is the electronic angular momentum), which, depending on the relative polarization of the laser beams, gives totally destructive interference in the absorption rate to the upper J=0 state of a zero-nuclear-spin atom, or a finite but time-dependent rate for population of the upper state for an atom with nonzero nuclear spin. A theoretical explanation of the effect shows the alignment of the nuclear spin as well as the population of the upper state to be time dependent. Isotope ratios were measured in Ba and Sr as a function of laser polarization and delay time, and compared with theory.