gebhart/patrepeval huggingface dataset:
Glutamine Transport in Rat Kidney Mitochondria in Metabolic Acidosis (1974)

In order to study factors regulating renal ammoniagenesis, the transport and metabolism of L-glutamine were studied in mitochondria from kidneys of control and acidotic rats. On incubation in 1 mM [(14)C]glutamine, there was production and accumulation of [(14)C]glutamate within the matrix space. However no [(14)C]glutamine was detected in the matrix space, even with 10 mM [(14)C]glutamine as substrate or with inhibition of glutamine deamidation (low temperature, p-chloromercuribenzoate, mersalyl). These results suggest that glutamine crosses the inner membrane by a carrier-mediated step and that this step is rate-limiting in glutamine deamidation. In chronic acidosis there is a fourfold increase in the uptake of radioactivity from [(14)C]glutamine, but not from alpha-ketoglutarate, glutamate, or acetate. In 3-h acidosis, before any increase in extracted glutaminase levels, there is a significant and reproducible increase (39+/-3.8%, n = 25) in matrix uptake of radioactivity from [(14)C]glutamine and also an increased ammonia production (17+/-3.7%, n = 12). Administration of furosemide produces a similar degree of potassium depletion and a greater degree of sodium depletion over 3 h when compared to a 3-h acidosis. However, it produces no change in mitochondrial uptake of radioactivity. These results show that the adaptation of renal glutamine metabolism observed in acidosis is due to the acidosis and is demonstrable in isolated rat kidney mitochondria. The site of adaptation is in the carrier system, which transports glutamine across the inner membrane. The increased transport in acidosis delivers more glutamine to glutaminase, which results in the increased renal ammonia production.
Human T Lymphocyte Subpopulations: Studies of the Mechanism by Which T Cells Bearing Fc Receptors for IgG Suppress T-Dependent B Cell Differentiation Induced by Pokeweed Mitogen (1979)

Abstract The mechanism by which human T lymphocytes bearing receptors for IgG (TG cells) suppress B cell differentiation promoted by pokeweed mitogen (PWM) and helper TM cells was studied. In this model system, autologous TG cells were shown to suppress via soluble factors released without detectable cell proliferation. In order to release these factors, TG cells needed to interact with PWM in addition to their reaction with IgG immune complexes during the isolation procedure. Suppression occurred only when TG cells were added early to mixtures of helper T and B cells cultured in the presence of PWM. B lymphocytes appeared to be resistant to suppression under a variety of experimental conditions. B cells “preactivated” by helper cells and PWM differentiated into plasma cells without any further help and were resistant to suppression by TG cells. B lymphocytes re-isolated from 2-day cultures containing TM cells, TG cells, and PWM retained their capacity to differentiate into plasma cells when cultured with helper T cells and PWM. B cell differentiation induced by helper supernatants was resistant to activated TG cells or their soluble factors. When TM cells were preincubated with suppressor supernatants, their ability to induce B cell differentiation was reduced; in contrast, similar pretreatment of B cells had no effect on their differentiation. These results suggest that TG cells can suppress the induction of polyclonal B cell differentiation by acting indirectly on helper TM cells.
Internet Message Access Protocol version 4 - LIST Command Extensions (2008)

IMAP4 has two commands for listing mailboxes: LIST and LSUB. As we
have added extensions, such as Mailbox Referrals, that have required
specialized lists we have had to expand the number of list commands,
since each extension must add its function to both LIST and LSUB, and
these commands are not, as they are defined, extensible. If we've
needed the extensions to work together, we've had to add a set of
commands to mix the different options, the set increasing in size with
each new extension. This document describes an extension to the base
LIST command that will allow these additions to be done with mutually
compatible options to the LIST command, avoiding the exponential
increase in specialized list commands. [STANDARDS-TRACK]
Segmented and self-adjusting wind turbine rotors. Final report (1976)

An investigation was carried out to examine the use of blade aeroelastic properties for providing rotational speed control for a wind turbine generator (WTG). The study was specifically directed at obtaining a rotor configuration that has the capability for maintaining nearly constant torque at constant RPM in the presence of varying wind conditions and is aimed at eliminating the current requirement for mechanical pitch change devices. The approach considered is one in which rotor twist due to aerodynamic loading is used to adjust the blade's pitch as the wind speed changes. The preliminary design concept that has evolved is a flexible rotor blade formed from a series of individual, light, rigid segments that are arranged along the blade spar. Each segment can rotate around the spar but is restricted in pitch by a nonlinear mechanical spring. The results of performance calculations as well as vibration and flutter analyses are presented. Based on these results, the concept appears to provide an attractive solution to the problem of WTG operation in a varying wind field.
[6 + 4] and [4 + 2] Cycloaddition Reactions of Cobaloxime 1,3-Dienyl Complexes and Tropones (2006)

1,3-Dien-2-yl(Rpyr)bis(dimethylglyoximato) cobalt(III) complexes (R = H, NMe2) have been shown to participate in cycloaddition reactions with a variety of tropones. In general, tropones that do not contain electron-withdrawing substituents react with dienyl complexes via [6 + 4] cycloaddition and tropones that are substituted with at least one additional electron-withdrawing group react via [4 + 2] cycloaddition. Both types of metal-substituted cycloadducts ([6 + 4] and [4 + 2]) presented here have also been characterized by X-ray crystallography.
A Visual Attention Model for Omnidirectional Images (2010)

Establishing and maintaining an empathic relationship is probably the most crucial factor for successful subsequent eHealth coaching. It was of paramount importance to get to know the patient first, and the asynchronous interaction aspect presented challenges because of the delay in response times (both ways). It also presented opportunities for reflection before answering. The health care professionals found they had to provide both relational communication and goal-oriented coaching when using eHealth solutions. Going forward, the quality of the health care professional-patient interaction will need attention if patients are to benefit from collaborative eHealth coaching fully.
The office of the future (1986)

Abstract Technology tends to be characterised as something that lives, has emotions and is all-powerful. Examples are the film 2001 in which a mad computer called HAL eliminated the humans which it had been created to serve, and Harvey Matusow’s book The Beast of Business which provides a number of horror stories about computers and is dedicated, with some anxiety, to ‘man’[1] More serious examples of the power of technology and of the technocracy are provided by Alvin Gouldner. [2] He points out that the new technocrats are not humble but arrogant, as they claim that their work is based on the best knowledge and science. Also, the nature of their expertise means that they and the technical process can not be easily controlled. Technical products can be appraised but the technical design process cannot be supervised, Gouldner argues that science and technology tend to assume a panacea-like character; the belief is that, given only time, all problems will capitulate to it. Science can provide the Utopian solution.
Histological and biochemical analysis of emulsified lesions in tissue induced by high intensity focused ultrasound. (2011)

As recently shown, shock wave heating and millisecond boiling can be used to obtain mechanical emulsification of tissue with or without evident thermal damage, which can be controlled by varying the parameters of the high intensity focused ultrasound exposure. The goal of this work was to examine these bioeffects using histological and biochemical analysis. Lesions were created in ex vivo bovine heart and liver using a 2-MHz transducer and pulsing scheme with 71 MPa in situ shock amplitude, 0.01 duty factor, and 5–500 ms pulse duration. Mechanical tissue damage and viability of cells in the lesions were evaluated histologically using conventional staining techniques (H&E and NADH-diaphorase). Thermal effects were quantified by measuring denaturation of salt soluble proteins in the treated area and confirmed by histology. By visual observation, the liquefied lesions obtained with shorter pulses (&lt; 15 ms) did not show any thermal damage that correlated well with the results of both histology and protein analysis. Increasing the pulse duration resulted in an increase in thermal damage; both protein analysis and NADH-diaphorase staining showed denaturation that was visually observed as whitening of the lesion content. [Work supported by NSBRI through NASA NCC 9-58, NIH EB007643 and DK007742.]
Remote control and robotics in construction engineering (1991)

This paper presents some topics on remote control and teleoperation in the construction fields. A teleoperated system, able to assembly and manipulate objects, is working in the laboratory of the Department of Mechanics. Politecnico di Milano, with the aim to improve the interface among operator and remote structure. Use of CAD/CAM is also presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Bismuth nanowire arrays: Synthesis and galvanomagnetic properties (2000)

This paper reports galvanomagnetic properties of arrays of single-crystal bismuth nanowires, with diameters of 7 to 200 nm, embedded in an amorphous porous anodic alumina matrix. A sample preparation technique is described that makes it possible to obtain nanowires with diameters below 10 nm. The wires are single crystals, with their long axes oriented in the bisectrix/trigonal plane, about 19\ifmmode^\circ\else\textdegree\fi{} from the bisectrix axis. The temperature dependence $(1.4\mathrm{K}<~T<~300\mathrm{K})$ of the electrical resistance, longitudinal magnetoresistance $(0\mathrm{T}<~B<~5\mathrm{T}$ with $1.4<~T<~75\mathrm{K},$ and $0T<~B<~1\mathrm{T}$ with $80<~T<~300\mathrm{K})$ and transverse magnetoresistance $(0\mathrm{T}<~B<~5\mathrm{T}$ with $1.4<~T<~75\mathrm{K})$ of the nanowires are given. The results extend previous work to wires of narrower diameter, and confirm the existence of the semimetal-semiconductor phase transition seen in the magnetoresistance. The data are discussed qualitatively in terms of the interplay between the electron cyclotron radii, electron scattering on the wire walls, size-induced energy level quantization, and the transfer of carriers between the different carrier pockets of the Fermi surface. Nanowires of Bi are theoretically predicted to have a much higher thermoelectric figure of merit than bulk Bi.
Specific high performance liquid chromatographic determination of the molecular weight and concentration of hyaluronic acid in complex mixtures by labelled hyaluronate binding proteins (1991)

A simple High performance liquid chromatographic (HPLC) method for the specific determination of the molecular weight and concentration of hyaluronic acid (HA) in complex mixtures has been developed. Hyaluronate-binding proteins isolated from bovine cartilage labelled by 125I or fluoresceinisothiocyanate were used as specific markers. The specific binding affinities of the markers were compared and were found to have association constants of 1.6 x 10(7) M-1 and 1.2 x 10(7) M-1 respectively. The HA levels and molecular weight distributions can be easily determined in the range 10-500 ng/mL in complex mixtures by the use of markers, molecular sieving HPLC columns and appropriate detectors. It has been demonstrated clearly that the method is useful for the highly specific determination of the parameters in complex biological samples such as serum and synovial fluids and is recommended for clinical applications.
Spatial Epigenome Sequencing at Tissue Scale and Cellular Level (2021)

Abstract Spatial biology is emerging as a new frontier of biomedical research in development and disease, but currently limited to transcriptome and a panel of proteins. Here we present spatial epigenome profiling for three histone modifications (H3K27me3, H3K4me3, H3K27ac) via next-generation sequencing by combining in-tissue CUT&Tag chemistry and microfluidic deterministic barcoding. Spatial chromatin states in mouse embryos or olfactory bulbs revealed tissue type-specific epigenetic regulations, in concordance with ENCODE reference data, but providing spatially resolved genome-wide profiles at tissue scale. Using fluorescence imaging to identify the tissue pixels (20μm) each containing one nucleus allowed us to extract single-cell epigenomes in situ. Spatial chromatin state profiling in tissue may enable unprecedented opportunities to study epigenetic regulation, cell function and fate decision in normal physiology and pathogenesis.
Model predictive control-based drive assist control in Electric vehicle &#x2014; An application to inter distance control considering human model (2012)

Traffic accidents have become social trouble along with the increase in drivers and diversification. In traffic accidents the rear-end collision includes the risk of severe injury. About 30 percent of the cause of traffic accidents is the collision accidents. Therefore, this paper proposes two methods to control the vehicle. One is the safe and comfortable inter-vehicular distance control considering the cut-out and the cut-in with force sensory accelerator and brake pedal. This inter-vehicular distance control is used model predictive control-based three evaluation indexes. To prompt proper pedal operation, force sensory pedal motor generates pedal assist torque. The other is driver behavior model presented in quantification the driver's acknowledgment. To achieve this, evaluation index based on the visual acknowledgment information of drivers is used. Driving simulator experiment results are shown to verify the effect of the proposed method.
Hairpin--dimer equilibrium of a parallel-stranded DNA hairpin: formation of a four-stranded complex (1997)

The 24mer deoxyoligonucleotide 3'-d(T)10-5'-5'-d(C)4- d(A)10-3'(psC4) with an uncommon 5'-p-5'phosphodiester linkage was designed to enable the formation of a hairpin structure with unusual parallel-stranded stem. As reference hairpin structure with an antiparallel-stranded stem, the 24mer 5'-d(T)10-d(C)4-d(A)10-3'(apsC4) was chosen. The behaviour of these oligonucleotides at different temperatures, DNA and salt concentrations was characterised by a combination of UV melting, CD, CD melting, infrared and Raman spectroscopy, infrared melting and analytical ultracentrifugation. The parallel-stranded hairpin structure was found to be formed by psC4 only under conditions of low DNA concentration and low salt concentration. Increase of the NaCl concentration beyond the physiological level or high DNA concentration supports the formation of intermolecular multi-stranded structures. The experimental data are in agreement with a four-stranded complex formed by two molecules of psC4. The base pairing model of this asymmetric four-stranded complex is based on the pyrimidine motif of a triple helix with two bifurcated hydrogen bonds at the O4 of the thymine each directed towards one of the amino protons of both adenines. In contrast, the reference oligonucleotide apsC4 forms only an antiparallel-stranded hairpin under all experimental conditions.
Gravimetric Determinatioin of Styrene as Styrene Nitrosite (1947)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGravimetric Determinatioin of Styrene as Styrene NitrositeG. R. BondCite this: Anal. Chem. 1947, 19, 6, 390–392Publication Date (Print):June 24, 1947Publication History Published online1 May 2002Published inissue 24 June 1947https://pubs.acs.org/doi/10.1021/ac60006a010https://doi.org/10.1021/ac60006a010research-articleACS PublicationsRequest reuse permissionsArticle Views51Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Performance of alternative MAN architectures for high-speed data applications (1990)

The authors analyze the performance of alternative metropolitan area network architectures for traditional data networking and for emerging distributed client/server computing applications. A simple traffic model contains the essential features of distributed computing applications. Delay performance on the MAN is examined for two architectures: networking based on variable-size datagrams, and networking based on asynchronous transfer mode protocols that use short, fixed-length cells. It is shown that the traffic characteristic of client/server computing-bimodal message-length distributions and bursty, clustered arrivals-can have significant effects on the delay performance of MANs. In particular, the presence of large and variable-size datagrams leads to large delays and variabilities in delay in connectionless networks as the length of network connections increases. Networks that use small cells in the style of ATM provide superior end-to-end delay performance and therefore provide a superior architecture for MANs designed to carry a diverse traffic mix.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Classification and Elimination of Conflicts in Hardware Transactional Memory Systems (2011)

This paper analyzes the sources of performance losses in hardware transactional memory and investigates techniques to reduce the losses. It dissects the root causes of data conflicts in hardware transactional memory systems (HTM) into four classes of conflicts: true sharing, false sharing, silent store, and write-write conflicts. These conflicts can cause performance and energy losses due to aborts and extra communication. To quantify losses, the paper first proposes the 5C cache-miss classification model that extends the well-established 4C model with a new class of cache misses known as contamination misses. The paper also contributes with two techniques for removal of data conflicts: One for removal of false sharing conflicts and another for removal of silent store conflicts. In addition, it revisits and adapts a technique that is able to reduce losses due to both true and false conflicts. All of the proposed techniques can be accommodated in a lazy versioning and lazy conflict resolution HTM built on top of a MESI cache-coherence infrastructure with quite modest extensions. Their ability to reduce performance is quantitatively established, individually as well as in combination. Performance is improved substantially.
Proactive Radio Resource Optimization With Margin Prediction: A Data Mining Approach (2017)

Driven by the exponential surge on high data rate services, network operators are facing the challenges of how to enhance the capacity and optimize the coverage in a cost-efficient approach. However, traditional network optimization technologies passively adjust the network configurations based on network's congestion ratio, drop-off rate, coverage holes, etc., leading to suboptimum user experiences. Therefore, the objective of this paper is to optimize the network configurations by obtaining the accurate network status, user demand, and application request distribution based on the real-time data. The data mining technique is introduced to predict the resource margin based on historical measurement statistics. To explore the dynamic distribution of user demand and application request, a weighted k-nearest neighbors model is proposed to predict periodic characteristics of network traffics, denoting different temporal and spatial patterns of radio resource margins. In contrast to the traditional passive network optimization approaches, the radio resources can be reconfigured actively to meet the dynamic patterns of traffic loads by using the proposed optimization algorithm. Results prove that the proposed data mining model can capture the dynamics of traffic loads to optimize the traffic load balance and increase the efficiency of radio resource utilization using the network statistic data.
Data Management and Deployment of Cloud Applications in Financial Institutions and its Adoption Challenges (2012)

The Cloud has become a new vehicle for delivering resources such as computing and storage to customers on demand. Rather than being a new technology in itself, the cloud is a new business model wrapped around new technologies such as server Virtualization that take advantage of economies of scale and multi-tenancy to reduce the cost of using information technology resources. From one perspective, cloud computing is nothing new because it uses approaches, concepts, and best practices that have already been established. From another perspective, everything is new because cloud computing changes how we invent, develop, deploy, scale, update, maintains, and pay for applications and the infrastructure on which they run. Nonetheless, there exist an increasing number of large companies that are offering cloud computing infrastructure products and services that do not entirely resemble the visions of these individual component topics. The challenge of building consistent, available, and scalable data management systems capable of serving petabytes of data for millions of users has confronted the data management research community as well as large internet enterprises. Financial institutions are not strangers to cloud computing adoption. One of the earlier cloud uses in banks and financial institutions were for SaaS deployments, which allowed for more social media banking. However, now FI's face the issue of security due to the increased number of data leaks. As a result, cloud within IT strategies and architecture for FIs will increase the risk of a security breach among servers and networks unless there is an adoption of a multiyear cloud strategy to keep data protected. This paper highlights the data management in cloud applications and deployments of various services of cloud computing in Financial Institutions with the study of risk factors in the deployment of transaction data of Financial Institutions on clouds.