gebhart/patrepeval huggingface dataset:
Mechanoregulation of the Myofibroblast in Wound Contraction, Scarring, and Fibrosis: Opportunities for New Therapeutic Intervention (2013)

Given the important role that myofibroblasts play in pathologies as disparate as cutaneous scarring, organ fibrosis, and tumor progression, knowledge gained in the areas of intracellular signaling networks, mechanical signal transduction, extracellular matrix biology, and cell fate will support efforts to develop new therapies with a wide impact.
Suppression of Neuronal Hyperexcitability and Associated Delayed Neuronal Death by Adenoviral Expression of GABA<sub>C</sub>Receptors (2001)

The excessive neuronal excitation underlying several clinically important diseases is often treated with GABA allosteric modulators in an attempt to enhance inhibition. An alternative strategy would be to enhance directly the sensitivity of postsynaptic neurons to GABA. The GABA(C) receptor, normally found only in the retina, is more sensitive to GABA and demonstrates little desensitization compared with the GABA(A) receptor. We constructed an adenovirus vector that expressed cDNA for both the GABA(C) receptor rho(1) subunit and a green fluorescent protein (GFP) reporter and used it to transduce cultured hippocampal neurons. Transduced neurons were identified by fluorescence, double immunocytochemistry proved colocalization of the rho(1) protein and the reporter, Western blot verified the expected molecular masses, and electrophysiological and pharmacological properties confirmed the presence of functional GABA(C) receptors. rho(1)-GFP transduction resulted in an increased density of GABA(A) receptors as well as expression of novel GABA(C) receptors. This effect was not reproduced by addition of TTX or Mg(2+) to the culture medium to reduce action potentials or synaptic activity. In a model of neuronal hyperexcitability induced by chronic blockade of glutamate receptors, expression of GABA(C) receptors abolished the hyperactivity and the consequent delayed neuronal death. Adenovirus-mediated neuronal GABA(C) receptor engineering, via its dual mechanism of inhibition, may offer a way of inhibiting only those hyperexcitable neurons responsible for clinical problems, avoiding the generalized nervous system depression associated with pharmacological therapy.
Coordinated Beamforming Technology in TD-LTE-Advanced System (2010)

As extension of MIMO technology in cellular system with multiple cell sites, Cooperative Network MIMO is a hot topic for the research of future wireless communication. In current study of TD-LTE-Advanced (LTE-Advanced TDD) system, various coordinated beamforming schemes have shown to be very promising candidates. In this paper we introduce a few implementations of coordinated beamforming technology with different levels of coordination, together with system level simulations and analysis.
Cell Growth on Liquid Microcarriers (1983)

Anchorage-dependent cell growth is demonstrated on microcarriers of fluorocarbon fluid formed by emulsification and stabilized with polylysine.
A molten salt system with a ground base-integrated solar receiver storage tank (1999)

Recent developments in the optical concept of a solar reflective tower makes it attractive for melting solid salts and metals (e.g., potash, aluminum scrap) and heating liquids to high temperatures, 600-900°C (e.g., molten salts). In this paper, the reflective tower' concept is applied to heat a mixture of molten nitrate salts used as a heat transfer fluid to a steam generator in a solar power plant. Two approaches are analyzed and in both, the solar receiver is integrated in the storage tank. In the first approach, the heating is done through a conductive metal wall. and in the second, the molted salt is directly illuminated through a transparent window.
Syntheses and Biological Properties of Chiral Fluoroalkyl Quinuclidinyl Benzilates (1995)

Previously, (R)-quinuclidinyl (R)-4-iodobenzilate ((R,R)-IQNB), a muscarinic receptor antagonist, has been labeled with 123I and 125I for use in in vitro and in vivo studies in animals and humans. We have prepared fluoroalkyl analogs of QNB, which are amenable to labeling with 18F, for potential imaging applications with positron emission tomography. The enantiomers of (fluoroalkyl)benzilic acids were prepared via an enantioselective Grignard addition reaction. Subsequent coupling of the enantiomeric (fluoroalkyl)benzilic acid with a selected enantiomer of quinuclidinol provides fluorinated analogs of QNB with known stereochemistry at each of the stereogenic centers. These compounds exhibit different affinities for the muscarinic receptor tissue subtypes in vitro. (R,R)-4-(Fluoromethyl)-QNB, and (R,R)-IQNB, and (R,R)-4-(fluoroethyl)-QNB exhibit selectivity for the M1 subtype, and (R,S)-4-(fluoromethyl)-QNB exhibits selectivity for the M2 subtype.
Life-Cycle Income and Consumption Variability (2001)

By all accounts, economic inequality is growing?the rich are getting richer, and the poor are getting poorer. This Economic Commentary explores inequality in income and consumption and asks whether inequality is determined early in life, before individuals enter the labor market, or whether it becomes manifest during the working years
Water-soluble conjugated polymers as the platform for protein sensors (2009)

The booming development of protein detection requires simple, sensitive, and reliable biosensor systems. Water-soluble conjugated polymers have been widely used for protein sensing due to their distinct optical response in the presence of different analytes. This review summarizes the recent developments in water-soluble conjugated polymer-based protein sensors. Based on the different optical responses of conjugated polymers to proteins, these assays are categorized into three groups. The conformational change of cationic poly(thiophene)s is used to generate unique colorimetric or fluorescent transduction upon interaction with target proteins. Super-quenching of water-soluble poly(phenylene vinylene)s and poly(phenylene ethynylene)s has been developed into fluorescence turn-on and turn-off proteinassays. Energy transfer between poly(fluorene-co-phenylene) derivatives and acceptor dyes is also utilized to develop fluorescence turn-on proteinassays with amplified signal output. The fine-tuning of conjugated polymer structures will benefit the design of versatile optical probes to satisfy the sophisticated requirements for protein sensors.
Potential Health Benefits of Dietary Phytoestrogens: A Review of the Clinical, Epidemiological, and Mechanistic Evidence<sup>1</sup> (1998)

Phytoestrogens represent a family of plant compounds that have been shown to have both estrogenic and antiestrogenic properties. A variety of these plant compounds and their mammalian metabolic products have been identified in various human body fluids and fall under two main categories: isoflavones and lignans. A wide range of commonly consumed foods contain appreciable amounts of these different phytoestrogens. For example, soy and flax products are particularly good sources of isoflavones and lignans, respectively. Accumulating evidence from molecular and cellular biology experiments, animal studies, and, to a limited extent, human clinical trials suggests that phytoestrogens may potentially confer health benefits related to cardiovascular diseases, cancer, osteoporosis, and menopausal symptoms. These potential health benefits are consistent with the epidemiological evidence that rates of heart disease, various cancers, osteoporotic fractures, and menopausal symptoms are more favorable among populations that consume plant-based diets, particularly among cultures with diets that are traditionally high in soy products. The evidence reviewed here will facilitate the identification of what is known in this area, the gaps that exist, and the future research that holds the most potential and promise.
Alteration of Vein Cyclic 3′:5′ Nucleotide Concentrations During Changes in Contractility (1974)

The relative changes in vascular tissue levels of cyclic 3':5'-guanosine monophosphate (cGMP) and cyclic 3':5'-adenosine monophosphate (cAMP) were determined in bovine and canine vein strips that were quickfrozen during changes in contractility elicited by prostaglandins (PG) or isoproterenol. Prostaglandin F(2alpha)-induced venoconstriction was associated with increased vascular tissue levels of cGMP and increased ratios of cGMP to cAMP concentrations, but no consistent qualitative change in cAMP levels. In contrast, vein cAMP concentrations were increased during administration of the vasodilators PGE(2) and isoproterenol. The results suggest possible opposing roles for the two cyclic nucleotides in vasomotion.
Resistance to dasatinib in Philadelphia-positive leukemia patients and the presence or the selection of mutations at residues 315 and 317 in the BCR-ABL kinase domain (2007)

The emergence of resistance to the Bcr-Abl inhibitor imatinib mesylate in patients with Philadelphia chromosome-positive (Ph+) leukemia has prompted the development of second-generation compounds active against several imatinib-insensitive mutant forms of Bcr-Abl, including dasatinib (BMS-354825; Bristol-Myers Squibb). In order to assess which pre-existent or emerging kinase domain mutations are associated with decreased clinical efficacy of desatinib, we analyzed BCR-ABL kinase sequences before and during treatment in 21 Ph+ patients who failed to respond to or relapsed during dasatinib therapy. In all patients but one, resistance to dasatinib was invariably found to be associated with mutations at residue 315 and/or at residue 317.
Broadband circular disc microstrip antenna (1982)

A technique for broadening the bandwidth of the circular disc microstrip radiating element is described. Theory based on a simple circuit model is introduced and comparison with experimental work is shown. From this model, a matching circuit is devised, the resulting element giving a bandwidth of 35% (to a VSWR of 1.5) near 8 GHz. This makes the circular disc element suitable for a wide range of radar and communications antenna systems.
Knowledge on<i>Sclerocarya birrea</i>subsp.<i>caffra</i>with emphasis on its importance as a non-timber forest product in South and southern Africa: A Summary (2002)

Synopsis Sclerocarya birrea (marula) forms an integral part of the diet, tradition and culture of rural communities in southern Africa and also is central to various commercial initiatives. This second part of a review on the species provides an overview of current commercial activities, the policy framework within which commercialisation occurs, and future prospects with regard to domestication. Much work has been conducted over the years on the properties of S. birrea fruit, juice, nuts and oil. Despite this research there has been little commercialisation. Two main commercial enterprises trade marula products in South Africa: one, a large corporation, and the other, a rural development project. In Namibia, marula commercialisation is undertaken through a collaborative project between primary producers, a cooperative, contract processors and a local NGO. Commercialisation is influenced by a wide set of customary and government laws which regulate marula use in southern Africa, comprising different tenure systems, access rights, and levels of protection. Strong customary rules can be linked to the long history ofmarula use in the region, with clear evidence of early domestication and the selection of desirable traits by local people. Such knowledge has been applied in the development ofmarula domestication strategies, both by private plant breeders in Israel and southern Africa, and by the International Centre for Research in Agroforestry (ICRAF), which works with small-scale farmers to develop agroforestry options. A number of issues are raised by the domestication of marula which relate to intellectual property and benefitsharing. They include the compensation of small-scale farmers and original holders of local knowledge for the commercial use of such knowledge; the impact ofPlant Breeder's Rights on communities using marula; and the possibility of domestication shifting benefits from poorer groups of farmers to richer ones. Current and future commercialisation strategies clearly need to take these factors into account, and to balance associated costs and benefits.
Stress-dependent cardiac remodeling occurs in the absence of microRNA-21 in mice (2010)

MicroRNAs inhibit mRNA translation or promote mRNA degradation by binding complementary sequences in 3' untranslated regions of target mRNAs. MicroRNA-21 (miR-21) is upregulated in response to cardiac stress, and its inhibition by a cholesterol-modified antagomir has been reported to prevent cardiac hypertrophy and fibrosis in rodents in response to pressure overload. In contrast, we have shown here that miR-21-null mice are normal and, in response to a variety of cardiac stresses, display cardiac hypertrophy, fibrosis, upregulation of stress-responsive cardiac genes, and loss of cardiac contractility comparable to wild-type littermates. Similarly, inhibition of miR-21 through intravenous delivery of a locked nucleic acid-modified (LNA-modified) antimiR oligonucleotide also failed to block the remodeling response of the heart to stress. We therefore conclude that miR-21 is not essential for pathological cardiac remodeling.
X-Ray Investigations on Celluloses Grafted by the Thiocarbonation Method (1976)

Abstract It is a pleasure for me to contribute to the symposium held in honor of my colleague and old friend Vivian Stannett. The topic of this contribution is results of x-ray investigations on graft modified cellulose fibers.
MEMS-Capacitive Pressure Sensor Fabricated Using Printed-Circuit-Processing Techniques (2006)

Microelectromechanical systems (MEMS)-based capacitive pressure sensors are typically fabricated using silicon-micromachining techniques. In this paper, a novel liquid-crystal polymer (LCP)-based MEMS-capacitive pressure sensor, fabricated using printed-circuit-processing technique, is reported. The pressure sensor consists of a cylindrical cavity formed by a sandwich of an LCP substrate, an LCP spacer layer with circular holes, and an LCP top layer. The bottom electrode and the top electrode of the capacitive pressure sensor are defined on the top side of the LCP substrate and the bottom side of the top-LCP layer, respectively. An example pressure sensor with a diaphragm radius of 1.6 mm provides a total capacitance change of 0.277 pF for an applied pressure in the range of 0-100 kPa
A mannoprotein constituent of Candida albicans that elicits different levels of delayed-type hypersensitivity, cytokine production, and anticandidal protection in mice (1994)

To identify major immunogenic constituents of Candida albicans, the effect of a mannoprotein fraction (MP-F2) on the elicitation of a delayed-type hypersensitivity (DTH) reaction, cytokine production, and protection from a virulent Candida challenge in a mouse candidiasis model was studied. In mice immunized with whole cells of a low-virulence strain of C. albicans and thus protected against a challenge with a highly virulent strain of this fungus, MP-F2 was able to elicit a strong DTH response that was accompanied by splenocyte proliferation in vitro in the presence of Candida antigen. The supernatants of MP-F2-stimulated splenocyte cultures contained gamma interferon (IFN-gamma, a typical CD4+ T helper-1 (Th1) cytokine, but no interleukin-4, (IL-4), a typical CD4+ Th2 cytokine. IFN-gamma was produced by CD4+ cells, and its level could be greatly increased by the addition of anti-IL-4 or, mostly, anti-IL-10 antibodies to the CD4+ cell cultures. Upon a suitable schedule of immunization, MP-F2 was also able to induce a vigorous DTH response in Candida-uninfected mice, a response that could be efficiently transferred into naive recipients by CD4+ cells from the spleens of MP-F2-immunized mice. The immunization described above also conferred to mice a low degree of protection against a virulent Candida challenge, both in terms of median survival time and in the number of Candida cells in the kidney. However, while DTH induction by MP-F2 was as strong as that induced by whole cells, MP-F2-induced protection was significantly weaker than that conferred by Candida whole-cell immunization. Mice immunized with either MP-F2 or Candida whole cells had an inverted ratio between the number of CD4+ splenocytes producing IFN-gamma and that of cells producing IL-4, compared with nonimmunized animals. However, the number of IL-4-producing CD4+ cells was significantly higher in MP-F2-vaccinated, weakly protected mice than in Candida whole-cell-vaccinated, highly protected animals. Overall, our data suggest that the MP-F2 fraction contains one or more major immunogens of C. albicans which are capable of interfering with the balance of CD4+ Th1 and Th2 responses that is so critical in the outcome of host-Candida relationship and are thus potentially relevant in the mechanisms of Candida-specific DTH regulation and protection.
Immune reprogramming via PD-1 inhibition enhances early-stage lung cancer survival (2018)

Success of immune checkpoint inhibitors in advanced non-small-cell lung cancer (NSCLC) has invigorated their use in the neoadjuvant setting for early-stage disease. However, the cellular and molecular mechanisms of the early immune responses to therapy remain poorly understood. Through an integrated analysis of early-stage NSCLC patients and a Kras mutant mouse model, we show a prevalent programmed cell death 1/programmed cell death 1 ligand 1 (PD-1/PD-L1) axis exemplified by increased intratumoral PD-1+ T cells and PD-L1 expression. Notably, tumor progression was associated with spatiotemporal modulation of the immune microenvironment with dominant immunosuppressive phenotypes at later phases of tumor growth. Importantly, PD-1 inhibition controlled tumor growth, improved overall survival, and reprogrammed tumor-associated lymphoid and myeloid cells. Depletion of T lymphocyte subsets demonstrated synergistic effects of those populations on PD-1 inhibition of tumor growth. Transcriptome analyses revealed T cell subset-specific alterations corresponding to degree of response to the treatment. These results provide insights into temporal evolution of the phenotypic effects of PD-1/PD-L1 activation and inhibition and motivate targeting of this axis early in lung cancer progression.
Synthesis and Characterization of Spinel‐Type Gallia‐Alumina Solid Solutions (2005)

Abstract By precipitation with ammonia of ethanolic solutions containing the appropriate proportions of gallium and aluminium nitrate, following by calcination of the resulting gels at 773 K, mixed Ga 2 O 3 /Al 2 O 3 oxides having Ga:Al ratios of 9:1, 4:1, 1:1, 1:4 and 1:9 were obtained. Powder X‐ray diffraction showed that these mixed metal oxides form a series of solid solutions having the spinel‐type structure; also shown by γ‐Al 2 O 3 and γ‐Ga 2 O 3 . The specific surface area (determined by nitrogen adsorption at 77 K) was found to range from 160 m 2 g −1 for the mixed oxide having Ga:Al = 9:1 up to 370 m 2 g −1 for that having Ga:Al = 1:9. High resolution MAS NMR showed that Ga 3+ and Al 3+ ions occur at both tetrahedral and octahedral sites in the spinel‐type structure of the mixed metal oxides, although there is a preferential occupation of tetrahedral sites by Ga 3+ ions. A proportion of penta‐coordinated Al 3+ ions was also found. IR spectra of carbon monoxide adsorbed at 77 K showed that the mixed metal oxides have a considerable Lewis acidity, related mainly to tetrahedrally coordinated metal ions exposed at crystal surfaces. The characteristic infrared absorption band of coordinated (adsorbed) CO appears in the range 2205–2190 cm −1 , and its peak wavenumber is nearly independent of Ga:Al ratio in the mixed gallia‐alumina oxides.
À chacun son passé / Claude Beausoleil, Fort Sauvage, Montréal, l’Hexagone, coll. « Fictions », 1994,128 p., 15,95 $. / Robert Gagnon, La thèse, Montréal, Quinze, 1994, 240 p., 17,95 $ / Nicole Houde, Les oiseaux de Saint-John Perse, Montréal, la Pleine Lune, 1994, 204 p., 19,95$ / Micheline La France, Le visage d’Antoine Rivière, Montréal, l’Hexagone, coll. « Fictions », 1994, 208 p., 18 95 $. (1995)

À chacun son passé / Claude Beausoleil, Fort Sauvage, Montréal, l’Hexagone, coll. « Fictions », 1994,128 p., 15,95 $. / Robert Gagnon, La thèse, Montréal, Quinze, 1994, 240 p., 17,95 $ / Nicole Houde, Les oiseaux de Saint-John Perse, Montréal, la Pleine Lune, 1994, 204 p., 19,95$ / Micheline La France, Le visage d’Antoine Rivière, Montréal, l’Hexagone, coll. « Fictions », 1994, 208 p., 18 95 $.. An article from journal Lettres québécoises (Number 77, Spring 1995, pp. 5-64), on Érudit.
Highly Effective Catalytic Asymmetric Hydrogenations of α-Keto Esters and an α-Keto Acetal with New Neutral Chiral Pyrrolidinebisphosphine-Rhodium Complexes (1987)

Abstract Synthesis of new chiral pyrrolidinebisphosphine–rhodium complexes and their application to the asymmetric hydrogenations of α-keto esters and an α-keto acetal are described. Among them, MCCPM-Rh gave the highest optical yield (87%) of the α-hydroxy ester and MCPM-Rh gave the 75% optical yield of the α-hydroxy acetal at the substrate to catalyst ratio (1000:1).
Constants and variables in immunohistochemistry (2004)

Many efforts have been made to develop reliable methods for the quantification of immunohistochemical reaction products. Most of the corresponding studies have dealt with problems related to the development of adequate hardware and software, while fewer investigations have focused on variables of histotechnical or immunohistochemical methods. The present paper summarizes findings and experience obtained over many years in this latter field, and a total of 14 corresponding parameters were considered. The studies were performed with methods well established in the author's laboratory; namely immunohistochemistry for various pancreatic hormones and chromogranin A applying the peroxidase anti-peroxidase method on serial semithin sections from the mammalian endocrine pancreas. Optical densities of immunoreactivities were determined using an appropriate measuring program by the interactive image analysis system IBAS. All parameters investigated were found to influence densities of immunoreactivities, and those with major significance were: 1) the thickness of histologic sections; 2) the dilution range of the antisera used as first layers; 3) the type or composition of the buffers used for dilution of the antisera and of the chromogen di-aminobenzidine or as the rinsing solution. All these variables could be standardized in appropriate ways. It was not possible, however, to prevent batch-to-batch (inter-assay) variations. Finally, the results of the present investigations served to increase the efficiency of immunohistochemical staining by the applied methods.
Codon usage in<i>Pseudomonas aeruginosa</i> (1988)

We have generated a codon usage table for Pseudomonas aeruginosa. Codon usage in P. aeruginosa is extremely biased. In contrast to E. coli and yeast, P. aeruginosa preferentially uses those codons within a synonymous codon group with the strongest predicted codon-anticodon interaction. We were unable to correlate a particular codon usage pattern with predicted levels of mRNA expressivity. The choice of a third base reflects the high guanine plus cytosine content of the P. aeruginosa genome (67.2%) and cytosine is the preferred nucleotide for the third codon position.
Digital Control Techniques for Current Mode Control of Interleaved Quasi Square Wave Converter (2006)

The synchronous buck converter, in quasi square wave operation, and with interleaved parallel outputs has been successfully used in low voltage high current DC-supply for microprocessors. This topology results in fast transient response and high power density. In this paper, two digital control techniques for current sharing are implemented and tested. The digital control techniques are tested using a 150 MHz Texas Instrument TMS320F2812 DSP and studied with regard to the transient response