gebhart/patrepeval huggingface dataset:
Glycoprotein-specific immune responses in cats after exposure to feline herpesvirus-1 (1988)

To obtain synchronous infection, 10 cats were inoculated with feline herpesvirus-1 (FHV-1) on the oral, nasal, and conjunctival mucosa. Swab specimens of the nasal, conjunctival, and pharyngeal mucosa were obtained for virus isolation from each cat before inoculation and at 3-day intervals thereafter until postinoculation day 21. Recovery of virus and evidence of clinical signs were used to document FHV-1 infection. Serum was obtained from blood samples collected sequentially from each cat between day 0 and postinoculation day 90. Virus-neutralizing antibody titer was determined in all serum specimens. Immunoprecipitation with [35S]methionine- and [14C]glucosamine-labeled viral antigens, followed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, was performed on each specimen. Three precipitation bands with approximate molecular weights of 105,000, 68,000, and 60,000 were separated from [14C]glucosamine- and [35S]methionine-labeled immunoprecipitates. The concurrent detection of virus-neutralizing antibody and glycoprotein-specific immunoprecipitins implied that in cats, the FHV-1 glycoproteins were important in the induction of virus-neutralizing antibodies to FHV-1.
Protection of human amniotic epithelial cells (HAEC) from complement-mediated lysis: expression on the cells of three complement inhibitory membrane proteins. (1990)

Cultured human amniotic epithelial cells (HAEC) were found by immunofluorescence microscopy to express three complement inhibitory membrane proteins, CD59 antigen, decay-accelerating factor (DAF) and membrane attack complex (MAC) inhibitory protein (MIP), on their surfaces. The effects of incubation with Fab2 fragments of monoclonal antibodies (mAb) raised against these proteins on susceptibility of sensitized cells to lysis by homologous complement was examined. Percentage cell lysis was markedly increased in the presence of Fab2 anti-CD59 and to a lesser, but significant, extent in the presence of Fab2 anti-DAF. Fab2 anti-MIP did not alter the sensitivity of the cells to lysis by complement.
Characterization of Highly Strained nFET Device Performance and Channel Mobility with SMT (2010)

This paper compares and analyzes the strained negative channel field effect transistor (nFET) device performance and the channel mobility behavior obtained by the stress memorization technique (SMT) using two different types of nitride films. These nitride film properties and wafer bowing during SMT fabrication are investigated. The electrical properties of SMT strained nFET devices including current–voltage characteristics, transconductance, carrier mobility, and interface state are also analyzed. Although SMT nitride strain can enhance electron mobility, it is critical to control the nitride properties and its hydrogen content to minimize electron mobility degradation due to interface-state generation. Thus, a simple view of the essential physics of mobility enhancement in SMT strained nFETs has been provided. Results in this work also provide guidance to further nFET performance enhancement in the ever-more challenging device targets of future technology generations.
Synthesis and alkylation of tetrahydrocyclopentapyrazolols (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and alkylation of tetrahydrocyclopentapyrazololsRichard P. Williams, Victor J. Bauer, and Sidney R. SafirCite this: J. Med. Chem. 1970, 13, 4, 773–775Publication Date (Print):July 1, 1970Publication History Published online1 May 2002Published inissue 1 July 1970https://pubs.acs.org/doi/10.1021/jm00298a057https://doi.org/10.1021/jm00298a057research-articleACS PublicationsRequest reuse permissionsArticle Views98Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Plasma Protein Binding of Bepridil (1985)

The binding of the calcium-channel blocking agent, bepridil HCl (Vascor), to plasma proteins was investigated using radiolabeled bepridil and equilibrium dialysis. Greater than 99.7% of added bepridil-14C was found to freshly collected human plasma. The binding was characterized by a saturable high-affinity site (KD = 32 ng/mL = 87 nM) on alpha1-acid glycoprotein (AAG) or on an AAG-human serum albumin complex and lower affinity binding sites on albumin and other plasma macromolecules. Bepridil that is not bound to plasma proteins is extensively distributed into erythrocytes as evidenced by a red blood cell to free drug distribution coefficient of 71 +/- 7. Despite this high value, the blood to plasma ratio of bepridil averaged only 0.67 in humans, indicating that most of the circulating drug is bound to plasma proteins. Bepridil protein binding was not affected by additions of nonesterified fatty acids. Free fractions of bepridil were enhanced by addition of verapamil, nifedipine, diltiazem, disopyramide, and warfarin but only at concentrations above those achieved clinically. Bepridil was also displaced by the plasticizer, tris-(2-butoxyethyl)phosphate. Plasma obtained from a small number of angina patients prior to bepridil administration showed no differences in ability to bind bepridil compared with plasma obtained from healthy subjects.
Resistance switching and retention behaviors in polycrystalline La-doped SrTiO3 ceramics chip devices (2008)

Resistance switching and retention behaviors in polycrystalline La-doped SrTiO3 ceramics have been investigated. La-doped SrTiO3 ceramics exhibits resistance switching as large as that of thin-film devices and exhibits a long-term memory effect of over 5 h. By means of a complex impedance analysis, it was clarified that these resistance changes can be reasonably attributed to the change in the electrical potential barrier at the interfaces and the resistance of the grain boundary changes remarkably by the application of voltage pulses. From the resistance retention properties at various temperatures, it was found that the high-resistance state is very stable even at 125 °C, whereas the resistance in the low-resistance state increases with time and its relaxation speed becomes remarkably faster with increasing temperatures. These results imply that the migration of the point defects could change the distribution of the space charge near the interface, resulting in a change in the interface resistances.
Production of antibodies to human interferons in mice (1978)

Neutralizing antibodies were raised in mice that had been inoculated repeatedly with moderate quantities of human leukocyte interferon highly purified by affinity chromatography on immobilized anti-interferon globulins. Interferon preparations of lesser purity sensitized the mice to subsequent inoculations of interferon and almost invariably caused death before anti-interferon titers developed. Antibody-purified interferon stabilized by sodium dodecyl sulfate was a superior antigen to interferon that had received mouse serum albumin as an additive. The amount of antibody could be augmented by experimental induction of ascites. The antibodies specifically neutralized leukocyte and lymphoblastoid interferons but not those interferons obtained cultures of human foreskin fibroblasts, embryonic kidney cells, and amnion cells.
Origami design secrets: mathematical methods for an ancient art (2004)

Table of Contents Introduction Building Blocks Elephant Design Traditional Bases Folding Instructions Stealth Fighter. Snail. Valentine. Ruby-Throated Hummingbird. Baby. Splitting Points Folding Instructions Pteranodon. Goatfish. Grafting Folding Instructions Songbird 1. KNL Dragon. Lizard. Tree Frog. Dancing Crane. Pattern Grafting Folding Instructions Turtle. Western Pond Turtle. Koi. Tiling Folding Instructions Pegasus Circle Packing Folding Instructions Emu. Songbird 2. Molecules Folding Instructions Orchid Blossom. Silverfish. Tree Theory Folding Instructions Alamo Stallion. Roosevelt Elk. Box Pleating Folding Instructions Organist. Black Forest Cuckoo Clock. Uniaxial Box Pleating Folding Instructions Bull Moose Polygon Packing Crease Patterns Flying Walking Stick. Salt Creek Tiger Beetle. Longhorn Beetle. Camel Spider. Water Strider. Scarab Beetle. Cicada Nymph. Scarab HP. Cyclomatus metallifer. Scorpion HP. Euthysanius Beetle. Spur-Legged Dung Beetle. Hybrid Bases Folding Instructions African Elephant References Glossary of Terms Index
Measurement of variations in atmospheric refractive index with an airborne microwave refractometer (1953)

A micro\yave refra cto meter for aircraft use is described , and some of the so urces of error in the measuremen t of variations of a t mospheric re fractive index with t his instrumen t a re discussed. Observat ions were made up to 10,000 feet on 2 days near vVashington, D . C. Two refractive-index so undings taken 1Yz h ours apart showed changes that, in the coarser aspects, resembled changes shown by radiosonde data. The flu ctuation intensity changed erratically with ti me and place, but was usually greatest where the vertical gradient was changing. A rough analysis of the data showed that the larger fluc t ua tions occurred over distances of several hundred m eters, whereas over distances less than 5 mete rs t he flu ctuations were negligible (the r esponse of the i nstr ument wou ld have a llowed t he detection of ftuctuations occu rr ing within 0.5 meter). Large increases in i ndex were observed on entering cumulus clouds and intense flu ctuations we I'e noted within the clouds.
UrbanEye: An outdoor localization system for public transport (2016)

Public transport in suburban cities (covers 80% of the urban landscape) of developing regions suffer from the lack of information in Google Transit, unpredictable travel times, chaotic schedules, absence of information board inside the vehicle. Consequently, passengers suffer from lack of information about the exact location where the bus is at present as well as the estimated time to be taken to reach the desired destination. We find that off-the-shelf deployment of existing (non-GPS) localization schemes exhibit high error due to sparsity of stable and structured outdoor landmarks (anchor points). Through rigorous experiments conducted over a month however, we realize that there are a certain class of volatile landmarks which may be useful in developing efficient localization scheme. Consequently, in this paper, we design a novel generalized energy-efficient outdoor localization scheme - UrbanEye, which efficiently combines the volatile and non-volatile landmarks using a specialized data structure, the probabilistic timed automata. UrbanEye uses speed-breakers, turns and stops as landmarks, estimates the travel time with a mean accuracy of ±2.5 mins and produces a mean localization accuracy of 50 m. Results from several runs taken in two cities, Durgapur and Kharagpur, reveal that UrbanEye provides more than 50% better localization accuracy compared to the existing system Dejavu [1], and consumes significantly less energy.
Identification of PMF1 Methylation in Association with Bladder Cancer Progression (2008)

PMF1 was identified to be epigenetically modified in bladder cancer. The association of PMF1 methylation with tumor progression and its diagnostic ability using urinary specimens support including PMF1 assessment for the clinical management of bladder cancer patients.
Review of the Aged Respiratory System (1984)

Reviewing changes within aged human systems involves the controversy of pathological versus physiological alteration. Regardless of cause, changes do occur. A succinct investigation of the changing systems with possible implications for exercise is advantageous to physical and occupational therapists. The following review offers such a synopsis on the aging respiratory system. Pulmonary structure and function are reviewed, followed by a consideration of the mechanism controversies. Finally, exercise implications are presented for the therapist to contemplate and utilize in clinical practice.
Next‐generation mapping of Arabidopsis genes (2011)

Next-generation genomic sequencing technologies have made it possible to directly map mutations responsible for phenotypes of interest via direct sequencing. However, most mapping strategies proposed to date require some prior genetic analysis, which can be very time-consuming even in genetically tractable organisms. Here we present a de novo method for rapidly and robustly mapping the physical location of EMS mutations by sequencing a small pooled F₂ population. This method, called Next Generation Mapping (NGM), uses a chastity statistic to quantify the relative contribution of the parental mutant and mapping lines to each SNP in the pooled F₂ population. It then uses this information to objectively localize the candidate mutation based on its exclusive segregation with the mutant parental line. A user-friendly, web-based tool for performing NGM analysis is available at http://bar.utoronto.ca/NGM. We used NGM to identify three genes involved in cell-wall biology in Arabidopsis thaliana, and, in a power analysis, demonstrate success in test mappings using as few as ten F₂ lines and a single channel of Illumina Genome Analyzer data. This strategy can easily be applied to other model organisms, and we expect that it will also have utility in crops and any other eukaryote with a completed genome sequence.
Purification and catalytic properties of cephalexin synthesizing enzyme from Acetobacter turbidans (1987)

Using Acetobacter turbidans enzyme, enzymatic synthesis of cephalexin (CEX) from D-phenylglycine methylester (PGM) and 7-amino-3-deacetoxycephalosporanic acid (7-ADCA) was attempted. This enzyme was partially purified through ammonium sulfate fractionation, DEAE and CM-column chromatography, and Sephacryl S-200 gel filtration. The purified enzyme migrated as a single band on a polyacrylamide disc gel electrophoresis. This enzyme showed its maximal synthetic activity at pH 6.0 and and its activation energy was determined as 9.19 Kcal/mol. An unique kinetic pattern that the maximal conversion achieved was greatly affected by molar ratio of two substrates and the amount of enzyme loaded, was observed. The maximal conversion of 7-ADCA to CEX was 85% at the molar ratio of PGM to 7-ADCA, 2-4.
Design of OpenCL framework for embedded multi-core processors (2014)

In modern mobile embedded systems, various energy-efficient hardware acceleration units are employed in addition to a multi-core CPU. To fully utilize the computational power in such heterogeneous systems, Open Computing Language (OpenCL) has been proposed. A key benefit of OpenCL is that it works on various computing platforms. However, most vendors offer OpenCL software development kits (SDKs) that support their own computing platforms. The study of the OpenCL framework for embedded multi-core CPUs is in a rudimentary stage. In this paper, an OpenCL framework for embedded multi-core CPUs that dynamically redistributes the time-varying workload to CPU cores in real time is proposed. A compilation environment for both host programs and OpenCL kernel programs was developed and OpenCL libraries were implemented. A performance evaluation was carried out with respect to various definitions of the device architecture and the execution model. When running on embedded multi-core CPUs, applications parallelized by OpenCL C showed much better performance than the applications written in C without parallelization. Furthermore, since programmers are capable of managing hardware resources and threads using OpenCL application programming interfaces (APIs) automatically, highly efficient computing both in terms of the performance and energy consumption on a heterogeneous computing platform can be easily achieved.
Economic Evaluation of an Area-Wide Integrated Pest Management Program to Control the Asian Tiger Mosquito in New Jersey (2014)

Aedes albopictus is the most invasive mosquito in the world, an important disease vector, and a biting nuisance that limits outdoor activities. Area-wide integrated pest management (AW-IPM) is the recommended control strategy. We conducted an economic evaluation of the AW-IPM project in Mercer and Monmouth Counties, New Jersey with a controlled design (AW-IPM vs. control) from 2009 through 2011. The study analyzed financial documents and staff time for AW-IPM and surveyed an average of 415 randomly chosen households in AW-IPM and control areas each fall from 2008 through 2011. Hours lost from yard and porch activities were calculated as differences between actual and potential hours of these activities in an average summer week if there had been no mosquito concerns. Net estimated benefits of AW-IPM were based on cross-over and difference-in-difference analyses. Reductions in hours lost were valued based on respondents' willingness to pay for a hypothetical extra hour free of mosquitoes spent on yard or porch activities and literature on valuation of a quality adjusted life year (QALY). The incremental cost of AW-IPM per adult was $41.18 per year. Number of hours lost due to mosquitoes in AW-IPM areas between the base year (2008) and the intervention years (2009-2011) declined by 3.30 hours per summer week in AW-IPM areas compared to control areas. Survey respondents valued this improvement at $27.37 per adult per summer week. Over the 13-week summer, an average adult resident gained 42.96 hours of yard and porch time, worth $355.82. The net benefit over the summer was $314.63. With an average of 0.0027 QALYs gained per adult per year, AW-IPM was cost effective at $15,300 per QALY gained. The benefit-cost ratio from hours gained was 8.64, indicating that each $1 spent on AW-IPM gave adults additional porch and yard time worth over $8.
Über zwei neue Verfahren zur Einführung der Propinyliden‐Gruppe (1965)

Abstract Triphenyl‐propargyl‐phosphoniumbromid liefert in flüssigem Ammoniak mit Aldehyden Verbindungen, die den Propinyliden‐Rest HCC–CH enthalten. Diese Verbindungen werden besser aus Aldehyden bzw. Ketonen und der aluminiumorganischen Verbindung des Propargylbromids erhalten, indem man die zunächst entstehenden Hydroxyverbindungen halogeniert und mit 1.5‐Diaza‐bicyclo[4.3.0]nonen‐(5) dehydrohalogeniert.
Lewis Acid Catalysis in the Oxidative Cycloaddition of Thiophenes<sup>1</sup> (1997)

Thiophenes 1 were treated with m-chloroperbenzoic acid (m-CPBA) under BF(3).Et(2)O catalysis to afford thiophene S-monoxides. These could be reacted in situ as intermediary species with a number of dienophiles to provide arenes (with alkynes as dienophiles) or 7-thiabicyclo[2.2.1]hept-2-ene 7-oxides (with alkenes as dienophiles). It was also possible to isolate thiophene S-monoxides in solution and to cycloadd them in a second step. In either way it could be shown that the use of BF(3).Et(2)O enhances the yields of the oxidative cycloaddition of thiophenes considerably. Moreover a greater variety of dienophiles (29a, 29b, 29c) could be reacted with thiophenes than in the case of the noncatalyzed reaction. All cycloadditions catalyzed by BF(3).Et(2)O give only a single diastereoisomer as cycloadduct. The reactions show a high pi-facial selectivity, a fact that can be explained by the Cieplak-effect. Without added dienophiles, 2-methylthiophene (1e) gave a single dimer (36) of 2-methylthiophene S-monoxide, whereas 2,5-dimethylthiophene (1a) gave three dimers (32a-c). In the case of tetrasubstituted thiophenes, thiophene S-monoxides (e.g., 31b and 31c) could be isolated in substance.
Lunar Site Characterization and Mining (1992)

Lunar mining requirements do not appear to be excessively demanding in terms of volume of material processed. It seems clear, however, that the labor-intensive practices that characterize terrestrial mining will not suffice at the low-gravity, hard-vacuum, and inaccessible sites on the Moon. New research efforts are needed in three important areas: (1) to develop high-speed, high-resolution through-rock vision systems that will permit more detailed and efficient mine site investigation and characterization; (2) to investigate the impact of lunar conditions on our ability to convert conventional mining and exploration equipment to lunar prototypes; and (3) to develop telerobotic or fully robotic mining systems for operations on the Moon and other bodies in the inner solar system. Other aspects of lunar site characterization and mining are discussed.
The Role of FGL2 in the Pathogenesis and Treatment of Hepatitis C Virus Infection (2010)

Chronic hepatitis C virus (HCV) infection is a leading cause of liver disease worldwide and remains the most common indication for liver transplantation. The current standard of care leads to a sustained viral response of roughly 50% of treated patients at best. Furthermore, anti-viral therapy is expensive, prolonged, and associated with serious side-effects. Evidence suggests that a poor response to treatment may be the result of a suppressed anti-viral immunity due to the presence of increased numbers and activity of CD4(+)CD25(+)Foxp3(+) regulatory T cells (Treg cells). We and others have recently identified fibrinogen-like protein 2 (FGL2) as a putative effector of Treg cells, which accounts for their suppressive function through binding to Fc gamma receptors (FcγR). In an experimental model of fulminant viral hepatitis, our laboratory showed that increased plasma levels of FGL2 pre- and post-viral infection were predictive of susceptibility and severity of disease. Moreover, treatment with antibody to FGL2 fully protected susceptible animals from the lethality of the virus, and adoptive transfer of wild-type Treg cells into resistant fgl2-deficient animals accelerated their mortality post-infection. In patients with HCV infection, plasma levels of FGL2 and expression of FGL2 in the liver correlated with the course and severity of the disease. Collectively, these studies suggest that FGL2 may be used as a biomarker to predict disease progression in HCV patients and be a logical target for the development of novel therapeutic approaches for the treatment of patients with HCV infection.
Familial Aggregation of Parkinson Disease (2002)

Late-onset PD has a significant familial component. The magnitude of recurrence risk to relatives suggests a genetic etiology, without ruling out the possibility of a coexisting environmental component.
La flexibilidad interna en la reforma laboral 2010: puntos críticos (2010)

Las novedades introducidas en los instrumentos de modificacion de las condiciones de trabajo facilitan la flexibilidad interna negociada en la empresa, pero tambien pueden reforzar el poder de decision unilateral del empresario. Tambien sera dificil que la flexibilidad interna actue como alternativa al despido por cuanto son muchos los incentivos a la flexibilidad externa.