gebhart/patrepeval huggingface dataset:
Primary study of leptin and human hepatocellular carcinoma in vitro (2008)

Leptin and leptin receptor are simultaneously expressed in human hepatocellular carcinoma cell line HepG2. Addition of leptin (0 ng/mL-200 ng/mL) in 72 h periods indicated there is a concentration- and time-dependent correlation in the stimulation of HepG2 cell proliferation. The effect of proliferation by leptin is due to promotion of DNA synthesis and enhancement of mitotic activity. The relationship between leptin and human hepatocellular carcinoma cells might indicate that adipokine could be associated with the progression of human hepatocellular carcinoma.
Fabrication of Very Small Aperture Laser (VSAL) from a Commercial Edge Emitting Laser (2001)

In this paper we report a method for producing very small aperture lasers (VSALs) from low-cost, commercial index guided edge emitting diode lasers. The detailed fabrication procedure is provided and the VSALs are characterized. Both high power and high aperture power to background noise power ratio are obtained even with a small aperture. This fabrication method can be applied to most commercial diode lasers without knowledge of the detailed geometry and is highly reproducible.
Dual display of proteins on the yeast cell surface simplifies quantification of binding interactions and enzymatic bioconjugation reactions (2017)

Yeast surface display, a well-established technology for protein analysis and engineering, involves expressing a protein of interest as a genetic fusion to either the N- or C-terminus of the yeast Aga2p mating protein. Historically, yeast-displayed protein variants are flanked by peptide epitope tags that enable flow cytometric measurement of construct expression using fluorescent primary or secondary antibodies. Here, we built upon this technology to develop a new yeast display strategy that comprises fusion of two different proteins to Aga2p, one to the N-terminus and one to the C-terminus. This approach allows an antibody fragment, ligand, or receptor to be directly coupled to expression of a fluorescent protein readout, eliminating the need for antibody-staining of epitope tags to quantify yeast protein expression levels. We show that this system simplifies quantification of protein-protein binding interactions measured on the yeast cell surface. Moreover, we show that this system facilitates co-expression of a bioconjugation enzyme and its corresponding peptide substrate on the same Aga2p construct, enabling enzyme expression and catalytic activity to be measured on the surface of yeast.
Nanosphären aus polymerisierten Lipofullerenen (1999)

Eine besondere mechanische Stabilität weisen die sphärischen Nanostrukturen auf, die durch UV-initiierte Polymerisation aus dem polymerisierbaren Lipofulleren 1 in multilamellaren Lipidvesikeln entstehen. Die Polymerkugeln können gefüllt oder leer sein. R=COO(CH2)9C≡C−C≡C(CH2)4CH3.
Interface/border trap characterization of Al2O3/AlN/GaN metal-oxide-semiconductor structures with an AlN interfacial layer (2015)

We report the interface characterization of Al2O3/AlN/GaN MOS (metal-oxide-semiconductor) structures with an AlN interfacial layer. A thin monocrystal-like interfacial layer (AlN) is formed at the Al2O3/GaN to effectively block oxygen from the GaN surface and prevent the formation of detrimental Ga-O bonds. The suppression of Ga-O bonds is validated by X-ray photoelectron spectroscopy of the critical interface. Frequency-dispersion in C-V characteristics has been significantly reduced, owing to improved interface quality. Furthermore, using the conventional conductance method suitable for extracting the interface trap density Dit in MOS structures, Dit in the device with AlN was determined to be in the range of 1011–1012 eV−1 cm−2, showing one order of magnitude lower than that without AlN. Border traps near the gate-dielectric/GaN interface were identified and shown to be suppressed by the AlN interfacial layer as well.
Multilayer piezoelectric transducer design guidelines for low profile magnetic-less DC/DC converter (2011)

In this paper, multilayer piezoelectric transducer design guidelines are presented for a low profile magnetic-less DC/DC converter. Power capacity considerations are very important in designing magnetic less power converters with piezoelectric devices, as it has different characteristics from conventional power devices such as magnetic inductors and transformers. Piezoelectric devices have fundamental limitations on power handling, such as maximum operation voltage and current capacity. Using an electro-mechanically coupled equivalent circuit model of a piezoelectric element, the power capacity is discussed and the current capacity equations, including material constants, are derived. In addition, benefits and trade-offs of a multilayer structure application to improve power capacity of piezoelectric transducers are discussed and design considerations for a piezoelectric power application are given. Customized piezoelectric transducers can be designed based on the design guidelines to meet system requirements. Experimental results with a 15W prototype magnetic-less DC-DC converter using a multilayered piezoelectric transducer verify the feasibility of the research.
Asymmetric Simmons–Smith Reaction of Allylic Alcohols with Al Lewis Acid/N Lewis Base Bifunctional Al(Salalen) Catalyst (2008)

Three angles: A highly enantioselective Simmons–Smith reaction of trans-disubstituted allylic alcohols was achieved by using a catalytic amount of an Al(salalen) complex at room temperature (see scheme). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z705641_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Sustainable flue-gas quench : For waste incineration plants within a water-energy-environment nexus perspective (2017)

The function of a flue-gas quench is to remove additional contaminants from flue-gas and to reduce the wastewater from a waste incineration plant. The aim of this degree project is to find how the system is affected by using a quench and what factors limits the performance. This is done by modelling and simulating a waste incineration plant in Aspen Plus. Data and plant schematics were obtained by a study visit to Mälarenergi Plant 6 situated in Västerås, Sweden, which were used as model input and for model validation. The results have shown that the amount of wastewater can be reduced by more than half compared to a plant without a quench. The heat produced in the condenser, when discharging water to the boiler, would be lowered by up to 20%. For systems with a quench present when more water was discharged to the boiler both the heat production and the pollutant capturing became better. However, the system has limits regarding the amount that could be recirculated, in the form of temperature limits in different parts of the system. In addition, if the heat load is low there is an insufficient amount of wastewater generated in the condenser to run the quench. In that situation, clean (fresh) water needs to be used instead. Using clean water is unwanted since the plant will then consume more resources while still producing less heat than a plant without a quench would.
Epidermoid cysts of the spleen. (1973)

Epidermoid cysts of the spleen must be considered in the differential diagnosis of splenomegaly in children. The diagnosis of these large fluid-filled masses is suggested in the asymptomatic child, and in the absence of a history suggesting a parasitic cause and with appropriate radiographic studies, a preoperative diagnosis can be made with considerable accuracy. The characteristic radiographic findings are those of a mass in the left upper quadrant of the abdomen which displaces gut and left kidney. Although selective arteriography may help to confirm the correct preoperative diagnosis, arteriography is not often necessary. This report describes four cases of epidermoid cysts of the spleen.
Molecular Self-Assembly on Graphene on SiO<sub>2</sub> and h-BN Substrates (2013)

One of the suggested ways of controlling the electronic properties of graphene is to establish a periodic potential modulation on it, which could be achieved by self-assembly of ordered molecular lattices. We have studied the self-assembly of cobalt phthalocyanines (CoPc) on chemical vapor deposition (CVD) grown graphene transferred onto silicon dioxide (SiO2) and hexagonal boron nitride (h-BN) substrates. Our scanning tunneling microscopy (STM) experiments show that, on both substrates, CoPc forms a square lattice. However, on SiO2, the domain size is limited by the corrugation of graphene, whereas on h-BN, single domain extends over entire terraces of the underlying h-BN. Additionally, scanning tunneling spectroscopy (STS) measurements suggest that CoPc molecules are doped by the substrate and that the level of doping varies from molecule to molecule. This variation is larger on graphene on SiO2 than on h-BN. These results suggest that graphene on h-BN is an ideal substrate for the study of molecular self-assembly toward controlling the electronic properties of graphene by engineered potential landscapes.
Transmittance of Single-Crystal Magnesium Fluoride and IRTRAN-1* in the 02- to 15-μ Range (1963)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Allen L. Olsen and William R. McBride, "Transmittance of Single-Crystal Magnesium Fluoride and IRTRAN-1* in the 0.2- to 15-μ Range," J. Opt. Soc. Am. 53, 1003_1-1005 (1963) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
F.A.S.T. – Floor Field and Agent Based Simulation Tool (2019)

This chapter presents a floor field and agent based model (F.A.S.T.) of pedestrian motion. In an application, its parameters were fitted to one run in an evacuation exercise at a primary school. The simulations with these parameters were then compared to further runs during the same exercise.
Myristoylated alanine‐rich C kinase substrate phosphorylation promotes cholangiocarcinoma cell migration and metastasis via the protein kinase C‐dependent pathway (2009)

Myristoylated alanine-rich C kinase substrate (MARCKS), a substrate of protein kinase C (PKC) has been suggested to be implicated in cell adhesion, secretion, and motility through the regulation of the actin cytoskeletal structure. The quantitative real-time-polymerase chain reaction analysis revealed that MARCKS is significantly overexpressed in Opisthorchis viverrini-associated cholangiocarcinoma (CCA) (P = 0.001) in a hamster model, which correlated with the results of mRNA in situ hybridization. An immunohistochemical analysis of 60 CCA patients revealed a significant increase of MARCKS expression. Moreover, the log-rank analysis indicated that CCA patients with a high MARCKS expression have significantly shorter survival times than those with a low MARCKS expression (P = 0.02). This study investigated whether MARCKS overexpression is associated with CCA metastasis. Using a confocal microscopic analysis of CCA cell lines that had been stimulated with the PKC activator, 12-0-tetradecanoyl phorbol-13-acetate (TPA), MARCKS was found to be translocated from the plasma membrane to the perinuclear area. In addition, phosphorylated MARCKS (pMARCKS) became highly concentrated in the perinuclear area. Moreover, an adhesion assay demonstrated that the exogenous overexpression of MARCKS remarkably promoted cell attachment. Interestingly, after TPA stimulation, the CCA cell line-depleted MARCKS showed a decrease in migration and invasion activity. It can be concluded that in non-stimulation, MARCKS promotes cell attachment to the extracellular matrix. After TPA stimulation, PKC phosphorylates MARCKS leading to cell migration or invasion. Taken together, the results of this study reveal a prominent role for MARCKS as one of the key players in the migration of CCA cells and suggest that cycling between MARCKS and pMARCKS can regulate the metastasis of biliary cancer cells.
Transluminal Iliac Artery Dilatation (1974)

By means of a reinforced balloon catheter, percutaneous transluminal dilatation was used to treat 48 consecutive cases of atheromatous iliac artery narrowing. With no deaths and little increase in the time and risk of diagnostic arteriography, the procedure was successful in more than 80% of cases, giving immediate luminal enlargement and relief, as judged clinically, for up to six years, the maximum follow-up period. In properly selected patients, this technique should be used in preference to reconstructive vascular surgery. (<i>JAMA</i>230:117-124, 1974)
Effects of column parameters on optimization of gas chromatography/mass spectrometry (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffects of column parameters on optimization of gas chromatography/mass spectrometryJosef F. K. Huber, Eva. Matisova, and Ernst. KenndlerCite this: Anal. Chem. 1982, 54, 8, 1297–1304Publication Date (Print):July 1, 1982Publication History Published online1 May 2002Published inissue 1 July 1982https://pubs.acs.org/doi/10.1021/ac00245a010https://doi.org/10.1021/ac00245a010research-articleACS PublicationsRequest reuse permissionsArticle Views129Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Decoder-side hierarchical motion estimation for dense vector fields (2010)

Current video coding standards perform motion estimation at the encoder to predict frames prior to coding them. Since the decoder does not possess the source frames, the estimated motion vectors have to be transmitted as additional side information. Recent research revealed that the data rate can be reduced by performing an additional motion estimation at the decoder. As only already decoded data is used, no additional data has to be transmitted. This paper addresses an improved hierarchical motion estimation algorithm to be used in a decoder-side motion estimation system. A special motion vector latching is used to be more robust for very small block sizes and to better adapt to object borders. With this technique, a dense motion vector field is estimated which reduces the rate by 6.9% in average compared to H.264 / AVC at the same quality.
From Enzymes to “Designer Bugs” in Reductive Amination: A New Process for the Synthesis of L‐<i>tert</i>‐Leucine Using a Whole Cell‐Catalyst (2004)

Abstract A whole‐cell‐catalyst for the asymmetric reductive amination of α‐keto acids has been developed and applied for the synthesis of the non‐proteinogenic α‐amino acid L‐ tert ‐leucine. Besides the economical whole‐cell catalyst, bearing a leucine dehydrogenase from Bacillus cereus and a formate dehydrogenase from Candida boidinii , it is further advantageous that there is no need for the addition of external cofactor. The desired product is formed with high conversion and an enantiomeric purity of > 99 % ee.
Integral Images: Efficient Algorithms for Their Computation and Storage in Resource-Constrained Embedded Vision Systems (2015)

The integral image, an intermediate image representation, has found extensive use in multi-scale local feature detection algorithms, such as Speeded-Up Robust Features (SURF), allowing fast computation of rectangular features at constant speed, independent of filter size. For resource-constrained real-time embedded vision systems, computation and storage of integral image presents several design challenges due to strict timing and hardware limitations. Although calculation of the integral image only consists of simple addition operations, the total number of operations is large owing to the generally large size of image data. Recursive equations allow substantial decrease in the number of operations but require calculation in a serial fashion. This paper presents two new hardware algorithms that are based on the decomposition of these recursive equations, allowing calculation of up to four integral image values in a row-parallel way without significantly increasing the number of operations. An efficient design strategy is also proposed for a parallel integral image computation unit to reduce the size of the required internal memory (nearly 35% for common HD video). Addressing the storage problem of integral image in embedded vision systems, the paper presents two algorithms which allow substantial decrease (at least 44.44%) in the memory requirements. Finally, the paper provides a case study that highlights the utility of the proposed architectures in embedded vision systems.
Evaluation of a novel endoluminal brush method for in situ diagnosis of catheter related sepsis. (1997)

Diagnosis of CRS by the endoluminal brush method can be achieved without line sacrifice and is more sensitive (95%) and specific (84%) than extraluminal sampling of the catheter tip by the Maki roll technique (82% and 66%, respectively).
Small Hydrophobic Protein of Respiratory Syncytial Virus as a Novel Vaccine Antigen (2015)

are its ability to infect young infants in the presence of maternal neutralizing antibodies and its ability to reinfect throughout life.
Amyloid beta protein is internalized selectively by hippocampal field CA1 and causes neurons to accumulate amyloidogenic carboxyterminal fragments of the amyloid precursor protein. (1998)

A critical issue concerning Alzheimer's disease is its selectivity, which leads to cellular degeneration in certain brain areas but not in others, and whether this pathogenic selectivity involves products of the amyloid precursor protein (APP). Here, we show that the amyloid beta protein Abeta1-42 is accumulated gradually and is retained intact by field CA1, but not by other subdivisions, of organotypic hippocampal slice cultures. In contrast, the slightly shorter Abeta1-40 peptide was not sequestered selectively. Sequestration of Abeta1-42 was followed by the build-up of carboxyterminal fragments of the endogenous precursor protein that were identified by immunoprecipitation. Unlike the peptide uptake, this induction appeared to be stochastic at the cellular level. In addition, the APP fragments were distributed more broadly within the CA1 pyramidal neurons than the sequestered Abeta1-42, and they appeared to be localized to synaptic terminals in the molecular layer of the dentate gyrus and in the stratum lacunosum-moleculare of the subfield CA3. Concentrations of synaptophysin, a presynaptic marker, decreased as the number of neurons producing amyloidogenic species increased. These results indicate that exogenous Abeta1-42 sets into motion a sequence that involves 1) selective uptake of the peptide by vulnerable cells at risk in Alzheimer's disease, 2) markedly enhanced production of amyloidogenic precursor material, and 3) slow deterioration of central synapses.
EFFECT OF ROOT-ZONE COOLING ON THE GROWTH AND YIELD OF CUCUMBER AT SUPRAOPTIMAL AIR TEMPERATURE (2007)

ISHS XXVII International Horticultural Congress - IHC2006: International Symposium on Advances in Environmental Control, Automation and Cultivation Systems for Sustainable, High-Quality Crop Production under Protected Cultivation EFFECT OF ROOT-ZONE COOLING ON THE GROWTH AND YIELD OF CUCUMBER AT SUPRAOPTIMAL AIR TEMPERATURE
Changing concepts in HIV infection (1990)

Department of Medicine and Cancer Research Institute, University of California, School of Medicine, San Francisco, California, USA.
A newly identified hepatitis B type virus in tree squirrels. (1986)

Virus-associated particles have been isolated from the livers of three common gray tree squirrels (Sciurus carolinensis pennsylvanicus) that have histological evidence of hepatitis. Two of these livers were also positive by orcein staining, suggesting the presence of surface antigen in the cytoplasm of hepatocytes. Fractionation of these particles by CsCl density equilibrium gradient centrifugation and assay of the fractions for surface antigen, core antigen, and DNA polymerase activities demonstrate the presence of all three at an approximate density peak of 1.27. Electron microscopic examination of purified virus preparations showed spherical particles with a mean diameter of 25 nm. Initial characterization of the DNA polymerase product by gel electrophoresis showed a single DNase I sensitive band, migrating slightly faster than the woodchuck hepatitis virus DNA polymerase product. The presence of apparently cross-reacting antibodies was demonstrated by purified hepatitis B surface and/or core antigens binding to some squirrel sera in solid phase assays. Infected tree squirrels appear to lack detectable antigen in their sera. These results suggest that the tree squirrels studied are chronic carriers of a hepatitis B type virus. The host-virus interaction described herein may be useful in understanding the chronic carrier state associated with hepatitis B in man.
Magneto-optic waveguide hysteresis loops of ‘‘planar’’ magnetic garnet films (1989)

Epitaxial films of modified yttrium iron garnet which are used as optical waveguides for magneto-optic devices have nominally planar anisotropy so that their magnetization can be aligned by small in-plane fields. Films grown on (111) substrates usually have some residual cubic anisotropy that is difficult to measure in the active layer of the double- or triple-layer films used in single-mode waveguides. A new method to determine the magnetic properties of the optically active layer itself has been developed. It is based on magneto-optical hysteresis loops in which the Faraday rotation of the waveguided light is plotted against one component of a rotating in-plane magnetic field. Steps in these hysteresis loops are directly related to the sixfold symmetry of the magnetocrystalline anisotropy of these films. The influence of linear birefringence on the measured Faraday rotation, the magnetostrictive effects associated with the pressure of the prism used for optical coupling into the waveguide, and the advantages of end-fire coupling are discussed. These hysteresis loops are being used in the design of materials for magneto-optic isolators and other waveguide devices.