gebhart/patrepeval huggingface dataset:
The Effect of Persantin® on the Phosphate Compounds in Erythrocytes During Blood Conservation (1972)

The content of phosphate compounds in blood conserved at 2–4 °C in ACD, ACD with adenosine and ACD with adenosine and persantin has been investigated. The decomposition of high-energy phosphate compounds (and 2,3-DPG) was much slower in the solution containing adenosine withpersantin than in two other media during the 6-week period of blood conservation. The clinical importance of the application of persantin for the prolongation of blood conservation is discussed.
Apnea in Premature Infants and Incubator-Air-Temperature Changes (1970)

The thermal events associated with apneic spells-were recorded during the monitoring of selected premature infants housed in incubators controlled by servo mechanism to maintain skin temperature between 35.8 and 36.6°C. The temperature changes that occurred during the 120 seconds before the onset of apnea were compared to the changes measured exactly 15 minutes before each episode. Of the 126 apneic spells 70 occurred during a rise, 44 during a fall, and 12 during a plateau (no change) in air temperature. During the nonapneic control periods, there were 41 rises, 64 falls and 21 plateaus in temperature. The onsets of apnea, therefore, were preceded by rising air temperatures more commonly (p less than 0.001) than matched moments without apnea. This correlation, supported by dramatic examples of apnea with sudden increases in air temperature, adds to the evidence that present incubator thermal control may help trigger apnea.
Cryptanalysis of Noel McCullagh and Paulo S. L. M. Barreto¡¯s two-party identity-based key agreement. (2004)

Noel McCullagh and Paulo S. L. M. Barreto[1] proposed a two-party identity-based key agreement protocol in 2004,which can be used in either escrowed or escrowless mode. They also described conditions under which users of different Key Generation Centres can agree on a shared secret key. In this paper, we show that these two protocols are insecure against the key compromis impersonate attack,and the fix protocol has not the property of Perfect-Forword-Secrecy.We modify these protocols in three ways,which are secure against all attack and satisfy the property of Known-Key Security, Perfect-Forward-Secrecy, Key-Compromise Impersonation, Unknown Key-Share,and Key control and so on.
Relationship between extraction of H− ions optimized by plasma grid potential and plasma parameters in a bucket source (1992)

Although optimizing the magnetic filter position and the plasma grid potential is one of the most effective factors to enhance H− yield, details concerning their roles are not now clarified well. In this article, spatially resolved measurements of the electron energy distribution function, plasma fluctuations, and plasma parameters are presented. On the basis of these experimental results, we will discuss the roles of both the magnetic filter and the plasma grid biasing voltage Vb on enhancement of H− production and extraction of H− ions.
Valsalva manoeuvre in the assessment of baroreflex sensitivity in patients with coronary artery disease (1993)

The overshoot rise in arterial pressure after release of Valsalva strain is a natural challenge for baroreflex regulation of heart rate. To assess the feasibility of the Valsalva manoeuvre in the determination of baroreflex sensitivity (BRS), we measured the slope of the linear relationship between the length of the RR interval and preceding systolic blood pressure value during the overshoot phase after the strain and compared this index of BRS to a standard phenylephrine test in 64 subjects, of whom 58 had coronary artery disease. The BRS slopes obtained with the Valsalva manoeuvre showed a good linear correlation with the phenylephrine test (r = 0.77 in the 27 patients with two Valsalva and phenylephrine tests and r = 0.56 in the whole cohort). The correlation coefficients of the BRS slopes were better than in the phenylephrine test (r = 0.89 vs r = 0.85, P < 0.05). The rise in systolic blood pressure in the slope calculation area was higher than with phenylephrine (41 +/- 18 vs 30 +/- 10 mmHg, P < 0.01). The reproducibility of BRS slopes in successive tests was comparable with both methods. These results suggest that non-invasive assessment of BRS using Valsalva strain to induce blood pressure rise is possible in patients with coronary artery disease.
Thermal enhancement of IC packages (2002)

Plastic package thermal enhancement techniques that improve the heat dissipating capabilities of the packages are available to IC package design engineers. Evaluations of these techniques have been performed using test structure measurements and thermal FEA modeling. The techniques studied include the use of additional metal traces on the PCB to spread the heat away from the package, the use of heat slugs and heat spreaders inside the package to enhance heat transfer to the package leads and package body, and the use of high thermal conductivity mold compounds to improve thermal performance. Package types ranged from 8 pin SOIC's to 208 PQFP's with a broad range of chip sizes. Details of the measurement and modeling techniques are given with comparison of the models to the experimental results in many instances.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
View point tracking for 3D display systems (2005)

For 3D display systems, detection and tracking of the observer’s view point is necessary to render the correct view according to the observer position. In this paper, we present a new real-time view point tracking system using a single web cam. The system can easily be installed on a standard PC together with an autostereoscopic display or stereoscopic glasses (shutter, polarized, pulfrich, and anaglyph) with appropriate video cards. For view point tracking, the first step is to detect the observer position. Our detection method is based on boosted cascade of simple feature classifiers. The detected object is observer’s eyes for autostereoscopic displays or observer’s face with glasses for the other case. In the second step Lucas Kanade Tracker is used to track the eyes/face. The total process can achieve a frame rate of 20Hz on a Pentium IV 3.0 GHz computer in our implementation. 1. GENERAL INFORMATION 3D display systems are evolving very rapidly. Different display systems are available in the market such as: SeeReal
Bounded Model Debugging (2010)

Design debugging is a major bottleneck in modern very large scale integration design flows as both the design size and the length of the error trace contribute to its inherent complexity. With typical design blocks exceeding half a million synthesized logic gates and error traces in the thousands of clock cycles, the complexity of the debugging problem poses a great challenge to automated debugging techniques. This paper aims to address this daunting challenge by introducing the bounded model debugging methodology that iteratively analyzes bounded sequences of the error trace. Two techniques are introduced in this methodology to solve this growing problem. The first technique iteratively analyzes bounded subsequences of the error trace of increasing size until the error is found or the entire trace is analyzed. The second technique partitions the error trace into non-overlapping bounded sequences of clock cycles which are each separately analyzed. A discussion of these two techniques is presented and a unified methodology that leverages the strengths of both techniques is developed. Empirical results on real industrial designs show that for large designs and long error traces the proposed methodology can find the actual error in 79% of cases with the first technique and 100% of cases with the second technique. In cases where the methodology is not used only 21% of cases are able to find the actual error. These numbers confirm the benefits of the proposed methodology to allow conventional automated debuggers to handle much larger real-life circuits.
Effect of Permittivity and Permeability of a Flexible Magnetic Composite Material on the Performance and Miniaturization Capability of Planar Antennas for RFID and Wearable Wireless Applications (2009)

This paper is an investigation of the feasibility of applying a mechanically flexible magnetic composite material to radio frequency identification (RFID) planar antennas operating in the lower ultrahigh-frequency (UHF) spectrum (~300500 MHz). A key challenge is that the magnetic loss introduced by the magnetic composite must be sufficiently low for successful application at the targeted operating frequency. A flexible magnetic composite comprised of particles of Z-phase Co hexaferrite, also known as Co <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> Z, in a silicone matrix was developed. To the authors' knowledge, this is the first flexible magnetic composite demonstrated to work at these frequencies. The benchmarking structure was a quarter-wavelength microstrip patch antenna. Antennas on the developed magnetic composite and pure silicone substrates were electromagnetically modeled in Ansoft High-Frequency Sounder System full wave electromagnetic software. A prototype of the antenna on the magnetic composite was fabricated, and good agreement between the simulated and measured results was found. Comparison of the antennas on the magnetic composite versus the pure silicone substrate showed miniaturization capability of 2.4 times and performance differences of increased bandwidth and reduced gain, both of which were attributed in part to the increase in the dielectric and magnetic losses. A key finding of this paper is that a small amount of permeability (mu <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">r</sub> ~2.5) can provide a substantial capability for miniaturization, while sufficiently low-magnetic loss can be introduced for successful application at the targeted operating frequency. This magnetic composite shows the capability to fulfill this balance and to be a feasible option for RFID, flexible wearable, and conformal applications in the lower UHF spectrum.
Inclusion Compounds. XVII.<sup>1</sup> Catalysis of Decarboxylation by Cyclodextrins. A Model Reaction for the Mechanism of Enzymes (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInclusion Compounds. XVII.1 Catalysis of Decarboxylation by Cyclodextrins. A Model Reaction for the Mechanism of EnzymesFriedrich Cramer and Wolfgang KampeCite this: J. Am. Chem. Soc. 1965, 87, 5, 1115–1120Publication Date (Print):March 1, 1965Publication History Published online1 May 2002Published inissue 1 March 1965https://pubs.acs.org/doi/10.1021/ja01083a031https://doi.org/10.1021/ja01083a031research-articleACS PublicationsRequest reuse permissionsArticle Views518Altmetric-Citations118LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Structural tuning of the magnetic behavior in spinel-structure ferrite thin films (2000)

Epitaxial cobalt ferrite thin films provide a model system for understanding the magnetic properties of spinel structure ferrite thin films. We demonstrate that the anomalous magnetic behavior, observed in our antiphase-boundary-free films, can be explained in terms of cation distribution and lattice distortions. The magnetic anisotropy is a delicate balance between strain anisotropy, due to internal lattice strain or equivalent external strain effects, and magnetocrystalline anisotropy, due to cation distribution. By annealing the cobalt ferrite thin films and hence varying the cobalt cation distribution among the tetrahedral and octahedral sites and the strain state of the films, we are able to tune the symmetry and the magnitude of the magnetic anisotropy.
Evaluation of Optical Coherence Tomography Retinal Thickness Parameters for Use in Clinical Trials for Neovascular Age-Related Macular Degeneration (2009)

Manual correction of errors in automated OCT segmentation may be necessary for accurate interpretation of anatomic outcomes for clinical trials of neovascular AMD. In addition, although measurement of FCS remains preferable for assessment of central retinal thickness, accurate measurement of FCP may represent an adequate alternative when FCS is unavailable.
Cholesterol-lowering effects of oat β-glucan (2011)

Elevated total and low-density lipoprotein (LDL) cholesterol levels are considered major risk factors for cardiovascular disease. Oat β-glucan, a soluble dietary fiber that is found in the endosperm cell walls of oats, has generated considerable interest due to its cholesterol-lowering properties. The United States Food and Drug Administration (FDA) approved a health claim for β-glucan soluble fiber from oats for reducing plasma cholesterol levels and risk of heart disease in 1997. Similarly, in 2004 the United Kingdom Joint Health Claims Initiative (JHCI) allowed a cholesterol-lowering health claim for oat β-glucan. The present review aims to investigate if results from more recent studies are consistent with the original conclusions reached by the FDA and JHCI. Results of this analysis show that studies conducted during the past 13 years support the suggestion that intake of oat β-glucan at daily doses of at least 3 g may reduce plasma total and low-density lipoprotein (LDL) cholesterol levels by 5-10% in normocholesterolemic or hypercholesterolemic subjects. Studies described herein have shown that, on average, oat consumption is associated with 5% and 7% reductions in total and LDL cholesterol levels, respectively. Significant scientific agreement continues to support a relationship between oat β-glucan and blood cholesterol levels, with newer data being consistent with earlier conclusions made by the FDA and JHCI.
TP53 alterations in acute myeloid leukemia with complex karyotype correlate with specific copy number alterations, monosomal karyotype, and dismal outcome (2011)

To assess the frequency of TP53 alterations and their correlation with other genetic changes and outcome in acute myeloid leukemia with complex karyotype (CK-AML), we performed integrative analysis using TP53 mutational screening and array-based genomic profiling in 234 CK-AMLs. TP53 mutations were found in 141 of 234 (60%) and TP53 losses were identified in 94 of 234 (40%) CK-AMLs; in total, 164 of 234 (70%) cases had TP53 alterations. TP53-altered CK-AML were characterized by a higher degree of genomic complexity (aberrations per case, 14.30 vs 6.16; P < .0001) and by a higher frequency of specific copy number alterations, such as -5/5q-, -7/7q-, -16/16q-, -18/18q-, +1/+1p, and +11/+11q/amp11q13∼25; among CK-AMLs, TP53-altered more frequently exhibited a monosomal karyotype (MK). Patients with TP53 alterations were older and had significantly lower complete remission rates, inferior event-free, relapse-free, and overall survival. In multivariable analysis for overall survival, TP53 alterations, white blood cell counts, and age were the only significant factors. In conclusion, TP53 is the most frequently known altered gene in CK-AML. TP53 alterations are associated with older age, genomic complexity, specific DNA copy number alterations, MK, and dismal outcome. In multivariable analysis, TP53 alteration is the most important prognostic factor in CK-AML, outweighing all other variables, including the MK category.
Monophyly of class I aminoacyl tRNA synthetase, USPA, ETFP, photolyase, and PP‐ATPase nucleotide‐binding domains: implications for protein evolution in the RNA world (2002)

Protein sequence and structure comparisons show that the catalytic domains of Class I aminoacyl-tRNA synthetases, a related family of nucleotidyltransferases involved primarily in coenzyme biosynthesis, nucleotide-binding domains related to the UspA protein (USPA domains), photolyases, electron transport flavoproteins, and PP-loop-containing ATPases together comprise a distinct class of alpha/beta domains designated the HUP domain after HIGH-signature proteins, UspA, and PP-ATPase. Several lines of evidence are presented to support the monophyly of the HUP domains, to the exclusion of other three-layered alpha/beta folds with the generic "Rossmann-like" topology. Cladistic analysis, with patterns of structural and sequence similarity used as discrete characters, identified three major evolutionary lineages within the HUP domain class: the PP-ATPases; the HIGH superfamily, which includes class I aaRS and related nucleotidyltransferases containing the HIGH signature in their nucleotide-binding loop; and a previously unrecognized USPA-like group, which includes USPA domains, electron transport flavoproteins, and photolyases. Examination of the patterns of phyletic distribution of distinct families within these three major lineages suggests that the Last Universal Common Ancestor of all modern life forms encoded 15-18 distinct alpha/beta ATPases and nucleotide-binding proteins of the HUP class. This points to an extensive radiation of HUP domains before the last universal common ancestor (LUCA), during which the multiple class I aminoacyl-tRNA synthetases emerged only at a late stage. Thus, substantial evolutionary diversification of protein domains occurred well before the modern version of the protein-dependent translation machinery was established, i.e., still in the RNA world.
Analysis of Phosphorylated Sphingolipid Long-Chain Bases Reveals Potential Roles in Heat Stress and Growth Control in <i>Saccharomyces</i> (1999)

Sphingolipid long-chain bases and their phosphorylated derivatives, for example, sphingosine-1-phosphate in mammals, have been implicated as signaling molecules. The possibility that Saccharomyces cerevisiae cells also use long-chain-base phosphates to regulate cellular processes has only recently begun to be examined. Here we present a simple and sensitive procedure for analyzing and quantifying long-chain-base phosphates in S. cerevisiae cells. Our data show for the first time that phytosphingosine-1-phosphate (PHS-1-P) is present at a low but detectable level in cells grown on a fermentable carbon source at 25 degreesC, while dihydrosphingosine-1-phosphate (DHS-1-P) is only barely detectable. Shifting cells to 37 degreesC causes transient eight- and fivefold increases in levels of PHS-1-P and DHS-1-P, respectively, which peak after about 10 min. The amounts of both compounds return to the unstressed levels by 20 min after the temperature shift. These data are consistent with PHS-1-P and DHS-1-P being signaling molecules. Cells unable to break down long-chain-base phosphates, due to deletion of DPL1 and LCB3, show a 500-fold increase in PHS-1-P and DHS-1-P levels, grow slowly, and survive a 44 degreesC heat stress 10-fold better than parental cells. These and other data for dpl1 or lcb3 single-mutant strains suggest that DHS-1-P and/or PHS-1-P act as signals for resistance to heat stress. Our procedure should expedite experiments to determine how the synthesis and breakdown of these compounds is regulated and how the compounds mediate resistance to elevated temperature.
Cytotoxicity and activation of the Wnt/beta-catenin pathway in mouse embryonic stem cells treated with four GSK3 inhibitors (2014)

Out of the four tested GSK3 inhibitors, only CHIR-99021 and CHIR-98014 proved to be potent pharmacological activators of the Wnt/beta-catenin signaling pathway. But only in the case of CHIR-99021 high potency was combined with very low toxicity.
Parathyroid Hormone Regulates Fibroblast Growth Factor-23 in a Mouse Model of Primary Hyperparathyroidism (2007)

The importance of fibroblast growth factor 23 (FGF-23) in the pathogenesis of phosphate wasting disorders has been established, but controversy remains about how parathyroid hormone (PTH), which also stimulates urinary phosphate excretion, regulates the circulating level of FGF-23. We found that the serum FGF-23 concentration was higher in PTH-cyclin D1 transgenic mice, a model of primary hyperparathyroidism, than in wild-type mice. The serum FGF-23 concentration was significantly and directly correlated with serum PTH and calcium, and inversely correlated with phosphate levels in 90- to 118-week-old mice (all P < 0.005). Quantitative real-time reverse-transcriptase PCR revealed abundant expression of fgf23 in bone, especially in calvaria. The fgf23 expression in calvaria was significantly higher in the transgenic mice compared to the wild-type mice, and correlated well with serum FGF-23 levels. There was a direct correlation between the expression of fgf23 and the expression of osteocalcin and ALP, suggesting that activation of osteoblasts is important in the regulation of FGF-23. Serum FGF-23 levels decreased in the transgenic mice after parathyroidectomy. In conclusion, PTH plays a major role in the regulation of serum FGF-23 level in primary hyperparathyroidism, likely via activation of osteoblasts in bone.
Productivity during the workout process—toward the turnaround (1994)

Abstract Companies struggling to survive or to regain their competitive footing may find themselves in serious turnaround situations in which they will be forced to make tough decisions affecting their workers, their products and services, and their very futures. As this article shows, at times like these, productivity must remain among management's foremost concerns.
Fully 3D iterative CT reconstruction using polar coordinates (2013)

Under a reasonable set of assumptions, the memory size of the system matrix can be reduced by a factor corresponding to the number of projections. Using this strategy, iterative reconstruction from high resolution clinical and preclinical systems can be more easily performed using general-purpose personal computers.
Differential sublocalization of actin variants within the nucleus (2010)

Conventional actin has been implicated in various nuclear processes including chromatin remodeling, transcription, nuclear transport, and overall nuclear structure. Moreover, actin has been identified as a component of several chromatin remodeling complexes present in the nucleus. In animal cells, nuclear actin exists as a dynamic equilibrium of monomers and polymers. Actin-binding proteins (ABPs) such as ADF/cofilin and profilin play a role in actin import and export, respectively. However, very little is known about the localization and roles of nuclear actin in plants. In multicellular plants and animals, actin is comprised of an ancient and divergent family of protein variants. Here, we have investigated the presence and differential localization of two ancient subclasses of actin in isolated Arabidopsis nuclei. Although the subclass 1 variants ACT2 and ACT8 and subclass 2 variant ACT7 were found distributed throughout the nucleoplasm, ACT7 was often found more concentrated in nuclear speckles than subclass 1 variants. The nuclei from the act2-1/act8-2 double null mutant and the act7-5 null mutant lacked their corresponding actin variants. In addition, serial sectioning of several independent nuclei revealed that ACT7 was notably more abundant in the nucleolus than the subclass 1 actins. Profilin and ADF proteins were also found in significant levels in plant nuclei. The possible functions of differentially localized nuclear actin variants are discussed.