gebhart/patrepeval huggingface dataset:
Scheduling Algorithms for Effective Thread Pairing on Hybrid Multiprocessors (2005)

With the latest high-end computing nodes combining shared-memory multiprocessing with hardware multithreading, new scheduling policies are necessary for workloads consisting of multithreaded applications. The use of hybrid multiprocessors presents schedulers with the problem of job pairing, i.e. deciding which specific jobs can share each processor with minimum performance penalty, by running on different execution contexts. Therefore, scheduling policies are expected to decide not only which job mix will execute simultaneously across the processors, but also which jobs can be combined within each processor. This paper addresses the problem by introducing new scheduling policies that use run-time performance information to identify the best mix of threads to run across processors and within each processor. Scheduling of threads across processors is driven by the memory bandwidth utilization of the threads, whereas scheduling of threads within processors is driven by one of three metrics: bus transaction rate per thread, stall cycle rate per thread, or outermost level cache miss rate per thread. We have implemented and experimentally evaluated these policies on a real multiprocessor server with Intel Hyperthreaded processors. The policy using bus transaction rate for thread pairing achieves an average 13.4% and a maximum 28.7% performance improvement over the Linux scheduler. The policy using stall cycle rate for thread pairing achieves an average 9.5% and a maximum 18.8% performance improvement. The average and maximum performance gains of the policy using cache miss rate for thread pairing are 7.2% and 23.6% respectively.
Long‐term lithium treatment prevents neurotoxic effects of β‐bungarotoxin in primary cultured neurons (2002)

Lithium is the most commonly used drug for the treatment of manic-depressive illness. The precise mechanisms underlying its clinical efficacy remain unknown. In this study, we found that long-term exposure to lithium chloride protected cultured cerebellar granule neurons (CGNs) against beta-bungarotoxin (beta-BuTX)-induced neurotoxicity. This neuroprotection was exhibited at the therapeutically relevant concentration of 1.2 mM lithium. Pretreatments for 3-5 days (long-term) were required for protection to occur; but a 3 hr treatment (short-term) was ineffective. In contrast, a longer treatment for 6-7 days or a higher concentration of 3 mM lithium led not only to loss of the neuroprotective effect but also to a neurotoxic effect. These findings suggest that lithium protection is limited to its narrow window of concentration and apparently relevant to its narrow therapeutic index in clinical application. Measurement of intracellular calcium [Ca(2+)](i) revealed that neurotoxic concentrations of beta-BuTX markedly increased [Ca(2+)](i), which could be attenuated by long-term, but not short-term, lithium treatment. Thus, the protection induced by lithium in CGNs was attributed to its inhibition of calcium overload. In addition, the Ca(2+) signaling pathway, including reactive oxygen species production and mitochondrial membrane potential reduction, along with the neurotoxic effect of beta-BuTX was blocked by long-term, but not short-term, lithium treatment. All of these results indicate that a crucial step for lithium protection is modulation of [Ca(2+)](i) homeostasis and that lithium neurotoxicity possibly, at least in part, is due to calcium overload. In conclusion, our results suggest that lithium, in addition to its use in treatment of bipolar depressive illness, may have an expanded use in intervention for neurotoxicity.
Richardson, Indians and Empire: History, Social Memory and the Poverty of Postcolonial Theory (1984)

Canada's first novelist is the usual reply.1 He was born at Amherstberg in present day southern Ontario in 1796. When the War of 1812 broke out, he was sixteen, bored with school and fired up to join the Army in defence of Upper Canada against the Americans. He became a volunteer in the 41st Regiment, was involved in the surrender of Detroit to the British, took part in a number of skirmishes and battles in the years 1812 and 1813 in the Western District region of the front, until he was captured, together with most of his regiment, at the ignominious defeat at Moraviantown in October 1813. He spent a year as a prisoner of war in Frankfort, Kentucky under difficult circumstances before being paroled back to Canada, this time with a full commission in the British Army. On the way over to fight Napoleon's second coming, the Battle of Waterloo was fought and for the first time in a generation Europe found itself with an uneasy peace. Richardson became part of a surplus war machine, scratched and scraped for the retention of his full commission by getting posted to the West Indies for a year, before lapsing back into the life of a half-pay British officer spent mainly in France in the mid-twenties.
Taking the Lead Role in Intern Supervision: The Mentor Teacher Intern Project (2010)

Classroom teachers participate in many university teacher education programs as partners in the education of teacher candidates. The Mentor Teacher project was initiated in 2003 to allow teachers a voice in the school internship or student teaching process. This study investigated the strengths and weaknesses of the program through individual interviews and open-ended surveys. The program was perceived as very successful by the Mentor Teachers as they moved into a new level in their profession.
Ontogeny of glucose transport systems in the placenta and its progenitor tissues. (1996)

Glucose is the primary substrate for placental and fetal metabolism, however, it can be synthesized in the fetus from placentally transferred substrates at best in minimal amounts. Therefore, the growing glucose requirements of the fetus throughout pregnancy must be met by increases in placental transport capacity. Results reviewed here indicate that the GLUT1 isoform represents the major glucose transporter species in human, and very likely in all mammalian, placentae as well as in fetal membranes and its progenitor tissues. This isoform is abundant in all placental cell populations including those fronting to the maternal and fetal circulation independent of anatomical differences of the placentae. The developmental changes of GLUT1 mRNA are controversial but the amount of GLUT1 protein tends to increase during pregnancy until term. GLUT1 seems also to play the predominant role in glucose uptake in the oocytes and preimplantation cleavage stages of rodents. Its mRNA and protein levels increased during preimplantation development. Furthermore, GLUT1 was demonstrated in the trophectoderm of mouse blastocysts, the direct progenitor tissue of the placenta. GLUT2 is generally not detected in the chorioallantoic placenta. If present at all, GLUT3 seems to be the only candidate for complementing GLUT1 in placental glucose uptake and transport function. The absence of the insulin-sensitive GLUT4 in the placenta is in line with the current consensus of insulin-independent glucose transport. The fructose transporter GLUT5 was only detected in human spermatozoa. All data available at present underline the paramount importance of GLUT1 for glucose transfer in the developing fetoplacental unit.
Effect of Mild-to-Moderate Smoking on Viral Load, Cytokines, Oxidative Stress, and Cytochrome P450 Enzymes in HIV-Infected Individuals (2015)

Mild-to-moderate tobacco smoking is highly prevalent in HIV-infected individuals, and is known to exacerbate HIV pathogenesis. The objective of this study was to determine the specific effects of mild-to-moderate smoking on viral load, cytokine production, and oxidative stress and cytochrome P450 (CYP) pathways in HIV-infected individuals who have not yet received antiretroviral therapy (ART). Thirty-two human subjects were recruited and assigned to four different cohorts as follows: a) HIV negative non-smokers, b) HIV positive non-smokers, c) HIV negative mild-to-moderate smokers, and d) HIV positive mild-to-moderate smokers. Patients were recruited in Cameroon, Africa using strict selection criteria to exclude patients not yet eligible for ART and not receiving conventional or traditional medications. Those with active tuberculosis, hepatitis B or with a history of substance abuse were also excluded. Our results showed an increase in the viral load in the plasma of HIV positive patients who were mild-to-moderate smokers compared to individuals who did not smoke. Furthermore, although we did not observe significant changes in the levels of most pro-inflammatory cytokines, the cytokine IL-8 and MCP-1 showed a significant decrease in the plasma of HIV-infected patients and smokers compared with HIV negative non-smokers. Importantly, HIV-infected individuals and smokers showed a significant increase in oxidative stress compared with HIV negative non-smoker subjects in both plasma and monocytes. To examine the possible pathways involved in increased oxidative stress and viral load, we determined the mRNA levels of several antioxidant and cytochrome P450 enzymes in monocytes. The results showed that the levels of most antioxidants are unaltered, suggesting their inability to counter oxidative stress. While CYP2A6 was induced in smokers, CYP3A4 was induced in HIV and HIV positive smokers compared with HIV negative non-smokers. Overall, the findings suggest a possible association of oxidative stress and perhaps CYP pathway with smoking-mediated increased viral load in HIV positive individuals.
PHILADELPHIA PSYCHIATRIC SOCIETY (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue Archives of Neurology & Psychiatry HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Facial Plastic Surgery JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the Archives of Neurology & Psychiatry journal
A sparseness-mixing matrix estimation (SMME) solving the underdetermined BSS for convolutive mixtures (2004)

We propose a method for blindly separating real environment speech signals with as little distortion as possible in the special case where speech signals outnumber sensors. Our idea consists in combining sparseness with the use of an estimated mixing matrix. First, we use a geometrical approach to perform a preliminary separation and to detect when only one source is active. This information is then used to estimate the mixing matrix. Then we remove one source from the observations and separate the residual signals with the inverse of the estimated mixing matrix. Experimental results in a real environment (T/sub R/=130 ms and 200 ms) show that our proposed method, which we call sparseness-mixing matrix estimation (SMME), provides separated signals of better quality than those extracted by using only the sparseness property of the speech signal.
Mutational analysis of <i>NOTCH1, 2, 3</i> and <i>4</i> genes in common solid cancers and acute leukemias (2007)

NOTCH proteins (NOTCH1, NOTCH2, NOTCH3 and NOTCH4) play crucial roles in embryonic development. Also, mounting evidence indicates that NOTCH contributes to the pathogenesis of hematopoietic and solid malignancies. Recent studies reported a high incidence of gain-of-function mutations of the NOTCH1 gene in T-cell acute lymphoblastic leukemias (ALL). To see whether NOTCH1 mutation occurs in other malignancies, we analyzed NOTCH1 for the detection of somatic mutations in 334 malignancies, including 48 lung, 48 breast, 48 colorectal and 48 gastric carcinomas, and 142 acute leukemias (105 acute myelogenous leukemias, 32 B-ALLs and 4 T-ALLs) by single-strand conformation polymorphism assay. Also, to see whether other NOTCH genes harbor somatic mutations, we analyzed NOTCH2, NOTCH3 and NOTCH4 genes in the same tissue samples. Overall, we detected three NOTCH mutations in the cancers, which consisted of one NOTCH1 mutation in the T-ALLs (25.0%), one NOTCH2 mutation in the breast carcinomas (2.1%), and one NOTCH3 mutation in the colorectal carcinomas (2.0%). There was no NOTCH mutation in other malignancies analyzed. Our data indicate that NOTCH1 is mutated in T-ALL, but not in other common human cancers, and that NOTCH2, NOTCH3 and NOTH4 genes are rarely mutated in common human cancers. Despite the importance of NOTCH activation in many types of human cancers, mutation of NOTCH genes, except for NOTCH1 mutation in T-ALL, may not play an important role in the tumorigenesis of common cancers.
Phagocytic receptor signaling regulates clathrin and epsin-mediated cytoskeletal remodeling during apoptotic cell engulfment in<i>C. elegans</i> (2013)

The engulfment and subsequent degradation of apoptotic cells by phagocytes is an evolutionarily conserved process that efficiently removes dying cells from animal bodies during development. Here, we report that clathrin heavy chain (CHC-1), a membrane coat protein well known for its role in receptor-mediated endocytosis, and its adaptor epsin (EPN-1) play crucial roles in removing apoptotic cells in Caenorhabditis elegans. Inactivating epn-1 or chc-1 disrupts engulfment by impairing actin polymerization. This defect is partially suppressed by inactivating UNC-60, a cofilin ortholog and actin server/depolymerization protein, further indicating that EPN-1 and CHC-1 regulate actin assembly during pseudopod extension. CHC-1 is enriched on extending pseudopods together with EPN-1, in an EPN-1-dependent manner. Epistasis analysis places epn-1 and chc-1 in the same cell-corpse engulfment pathway as ced-1, ced-6 and dyn-1. CED-1 signaling is necessary for the pseudopod enrichment of EPN-1 and CHC-1. CED-1, CED-6 and DYN-1, like EPN-1 and CHC-1, are essential for the assembly and stability of F-actin underneath pseudopods. We propose that in response to CED-1 signaling, CHC-1 is recruited to the phagocytic cup through EPN-1 and acts as a scaffold protein to organize actin remodeling. Our work reveals novel roles of clathrin and epsin in apoptotic-cell internalization, suggests a Hip1/R-independent mechanism linking clathrin to actin assembly, and ties the CED-1 pathway to cytoskeleton remodeling.
Microstructure and Creep Behavior of a Si <sub>3</sub> N <sub>4</sub> –SiC Micronanocomposite (2009)

The microstructure and its influence on the creep behaviour of carbon derived Si 3 N 4 ‐SiC micro/nanocomposite tested in bending at temperatures from 1200° to 1400°C in air has been studied. No phase and microstructure change after creep test implied that material is stable at tested temperature range. After creep test only partial crystallization of glassy intergranular phase has been observed. Creep parameters n close to 1, apparent activation energy around 350 kJ/mol together with TEM observation indicated that the main creep mechanisms is solution precipitation controlled by interface reaction in combination with grain boundary sliding caused by the amorphous intergranular phases present in microstructure. However, the grain boundary sliding is hindered by local SiC particles interlocking neighboring Si 3 N 4 grains.
Antiviral properties of the seed extract of an Indian medicinal plant, Pongamia pinnata, Linn., against herpes simplex viruses: In-vitro studies on Vero cells (1993)

Pongamia pinnata, Linn., an Indian medicinal plant used in the Ayurvedha and Siddha traditional medicine systems, for treatment of clinical lesions of skin and genitalia, was evaluated for antiviral properties against herpes simplex virus type-1 (HSV-1) and type-2 (HSV-2) by in-vitro studies in Vero cells. A crude aqueous seed extract of P. pinnata completely inhibited the growth of HSV-1 and HSV-2 at concentrations of 1 and 20 mg/ml (w/v), respectively, as shown by complete absence of cytopathic effect.
<i>Database Systems</i>: A Directed Hypergraph Database: A Model for the Local Loop Telephone Plant (1982)

A database model that is a directed hypergraph is described in the context of an application to the telephone plant. There is particular emphasis on the fidelity of the application model to the “real world,” information hiding by modules, transaction concurrency, names of inventoried objects, and pending. Pending refers to the maintenance of a tree of possible future states of the inventory.
Integration-specific retrovirus expression in embryonal carcinoma cells. (1984)

The undifferentiated embryonal carcinoma (EC) cell line PCC4 aza 1 was infected with a selectable amphotropic retrovirus. Although EC cells are generally refractory to retroviral gene expression, we found that approximately 1 of 5,000-10,000 recombinant proviruses was transcribed in these cells. Cells containing an active recombinant provirus were cloned and expanded. Nucleic acid analysis revealed approximately one intact provirus per cell. Viral RNA levels were different for each cell clone examined [between 0.05% and 0.5% of the poly(A)+ RNA], and transcription was initiated and terminated in the long terminal repeats as in permissive differentiated cells. The cells retained an undifferentiated phenotype and remained positive for stage-specific embryonic antigen 1 and negative for H-2 surface antigens. The cells retained the block to the expression of other proviruses integrated at other chromosomal locations. The data suggest that a cis-acting genetic element, at or near the chromosomal site of integration, or mutations in the viral control elements themselves may be responsible for provirus expression in these cells.
Evolution of the mashup ecosystem by copying (2010)

Previous work has explored the structure of the mashup ecosystem, which can be modeled as a network of mashups and APIs. However, it did not offer an explanation for its growth. In this paper, we seek an answer to the question how mashup developers select APIs. One hypothesis that has been put forward is that APIs are selected by their popularity, that is, by preferential attachment. However, this hypothesis is unsatisfying, as it disregards that mashups are composed from multiple APIs, and neglects the learning between mashup developers. Instead, we propose a copying model. We test to what degree developers create mashups by copying other mashups. We show that a good fit between the actual distribution of APIs and our model can be obtained. We can conclude that copying plays a significant role in explaining how mashups are developed. We also identify open research questions raised by the results.
Cloning, characterization and expression analysis of a sucrose synthase gene from tropical epiphytic orchid <i>Oncidium</i> Goldiana (2003)

A full‐length cDNA encoding sucrose synthase was isolated from the tropical epiphytic orchid Oncidium Goldiana. The cDNA is 2829 bp in length containing an open reading frame of 2447 bp encoding 816 amino acids with a predicted molecular mass of 93.1 kDa. The deduced amino acid sequence of O . Goldiana sucrose synthase ( Osus ) shares more than 80% identity with those from other monocotyledonous plants. The sucrose synthase gene was demonstrated to encode a functional sucrose synthase protein by expression as recombinant protein in Escherichia coli . The Osus mRNA is present in all the tissues analysed, with the highest levels in strong sinks such as developing inflorescence and root tips. Incubation with sucrose or glucose resulted in a significant increase in the steady‐state Osus mRNA levels in root tips and mature leaves in a similar pattern to maize Sus1 . Expression of the Osus mRNA in mature leaves was markedly enhanced by anaerobic conditions and elevated CO 2 . The expression pattern and regulation of the gene suggest that the sucrose synthase plays an important role in the growth and development of the tropical epiphytic orchid O . Goldiana.
An SNF2 factor involved in mammalian development and cellular proliferation (2001)

Members of the SNF2 (Sucrose Non-Fermenter) family of chromatin-remodeling proteins function in processes ranging from DNA repair to transcription to methylation. Using differential display, we recently identified a novel member of the SNF2 family that is highly expressed at the mRNA level in proliferating cells and is down-regulated during apoptosis. We have named this gene PASG (Proliferation-Associated SNF2-like Gene). Northern blot analysis of adult mouse tissues shows PASG to be highly expressed in proliferating organs such as thymus, bone marrow, and testis and absent from nonproliferative tissues such as brain and heart. In situ hybridization analysis of mouse embryos shows that PASG is differentially expressed during development, with highest expression in developing face, limbs, skeletal muscle, heart, and tail. In vitro, PASG expression correlates with a shift from a quiescent to a proliferative state. Mice null for PASG (also known as LSH or Hells) are reported to die perinatally, although the mechanism for lethality is unclear (Geiman and Muegge, 2000). To test the hypothesis that PASG functions in cell proliferation, we compared 5-bromodeoxyuridine (BrdU) incorporation in C33A cells transiently transfected with PASG versus empty vector and found that PASG transfected cells showed a significant decrease in the amount of BrdU incorporation. These findings suggest that PASG plays a role in cell proliferation and may function in the development of multiple cell lineages during murine embryogenesis.
Transport: A Computer Program for Designing Charged Particle Beam Transport Systems (Rev. 2) (1970)

Transport is a first- and second-order matrix multiplication computer program intended for the design of static-magnetic beam transport systems. It has been in existence in various evolutionary versions since 1963. The present version, described in this manual, includes both first- and second-order fitting capabilities. (report superseded by SLAC-R-462).
The Synthesis of <scp>l</scp>-Aminosugar and the Studies of <scp>l</scp>-Pyranoses on the Ring III of Pyranmycins (2002)

The synthesis of a novel class of aminoglycoside, pyranmycin, and a convenient method for the preparation of 6-amino-L-idopyranosides were reported. One of the members in the reported pyranmycin families, TC010, has prominent activity against Escherichia coli, Staphylococcus aureus, and Bacillus megaterium. We also discovered that the (4)C(1) chair conformation on ring III of pyranmycin is essential for the antibacterial activity. [reaction: see text]
A Simple Method for Interactive 3D Reconstruction, Camera Calibration from a Single View. (2002)

We present a simple and intuitive method for interactive 3D reconstruction and camera calibration from a single image of a structured scene. The method is based on manual registration of two world planes. We present experimental results on some test images.