gebhart/patrepeval huggingface dataset:
Mechanism of Protective Effects of Tanshinone II-A(Tan II-A)on Intestine in Rats with Ischemia/Reperfusion Injury (2010)

Objective: To investigate the protective effects and mechanism of tanshinone Ⅱ-A(TanⅡ-A) on intestine in rats with ischemia /reperfusion injury.Methods: 24 SD rats weighing225 ～ 275g were divided into three groups with eight animals in each group including the sham-operation group,the control group and the tanshinone group.The TanⅡ-A were injected in 30 minutes before occlusion.The pH,the DAO and the TNF-αwere detected in 2h reperfusion.Results: After as long as 2 hours of reperfusion,the levels of PH value in membrane in expremental group were significantly higher than those in control group.The DAO content in expremental group was much lower than that in control group.The expression level of TNF-α in control group was significantly higher than that in control group and that in sham-operation group.The intestine pathology damage was less serious in expremental group that in control group.Conclusion: TanshinoneⅡ-A could protect intestine against ischemic reperfusion injury because of oxygen free radicals scavenging and repressing apoptosis of leal mucous cells by increasing intestinal blood flow and improving intestinal oxygenation
Comment on "Clustering by Passing Messages Between Data Points" (2008)

Frey and Dueck (Reports, 16 February 2007, p. 972) described an algorithm termed "affinity propagation" (AP) as a promising alternative to traditional data clustering procedures. We demonstrate that a well-established heuristic for the p-median problem often obtains clustering solutions with lower error than AP and produces these solutions in comparable computation time.
Star and linear imide oligomers containing reactive end-caps: preparation and thermal properties (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStar and linear imide oligomers containing reactive end-caps: preparation and thermal propertiesTsutomu Takeichi and J. K. StilleCite this: Macromolecules 1986, 19, 8, 2093–2102Publication Date (Print):August 1, 1986Publication History Published online1 May 2002Published inissue 1 August 1986https://pubs.acs.org/doi/10.1021/ma00162a001https://doi.org/10.1021/ma00162a001research-articleACS PublicationsRequest reuse permissionsArticle Views426Altmetric-Citations56LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Activated ERBB2/HER2 Licenses Sensitivity to Apoptosis upon Endoplasmic Reticulum Stress through a PERK-Dependent Pathway (2014)

HER2/Neu/ERBB2 is a receptor tyrosine kinase overexpressed in approximately 20% of human breast tumors. Truncated or mutant isoforms that show increased oncogenicity compared with the wild-type receptor are found in many breast tumors. Here, we report that constitutively active ERBB2 sensitizes human breast epithelial cells to agents that induce endoplasmic reticulum stress, altering the unfolded protein response (UPR) of these cells. Deregulation of the ERK, AKT, and mTOR activities elicited by mutant ERBB2 was involved in mediating this differential UPR response, elevating the response to endoplasmic reticulum stress, and apoptotic cell death. Mechanistic investigations revealed that the increased sensitivity of mutant ERBB2-expressing cells to endoplasmic reticulum stress relied upon a UPR effector signaling involving the PERK-ATF4-CHOP pathway, upregulation of the proapoptotic cell surface receptor TRAIL-R2, and activation of proapoptotic caspase-8. Collectively, our results offer a rationale for the therapeutic exploration of treatments inducing endoplasmic reticulum stress against mutant ERBB2-expressing breast tumor cells.
Suboptimal control of nonlinear systems: I. Unconstrained (1971)

Abstract An algorithm for suboptimal control of nonlinear unconstrained systems is developed. The result is closed loop, uses the familiar linear‐quadratic optimal approach, and minimizes computational time and effort. Numerous examples are presented.
The Sequence Read Archive (2010)

The combination of significantly lower cost and increased speed of sequencing has resulted in an explosive growth of data submitted into the primary next-generation sequence data archive, the Sequence Read Archive (SRA). The preservation of experimental data is an important part of the scientific record, and increasing numbers of journals and funding agencies require that next-generation sequence data are deposited into the SRA. The SRA was established as a public repository for the next-generation sequence data and is operated by the International Nucleotide Sequence Database Collaboration (INSDC). INSDC partners include the National Center for Biotechnology Information (NCBI), the European Bioinformatics Institute (EBI) and the DNA Data Bank of Japan (DDBJ). The SRA is accessible at http://www.ncbi.nlm.nih.gov/Traces/sra from NCBI, at http://www.ebi.ac.uk/ena from EBI and at http://trace.ddbj.nig.ac.jp from DDBJ. In this article, we present the content and structure of the SRA, detail our support for sequencing platforms and provide recommended data submission levels and formats. We also briefly outline our response to the challenge of data growth.
Building a better pipe (1991)

This paper reports that a fundamental building block for natural transmission lines, is steel, and it will be for the foreseeable future. Plastic pipe is the choice for distribution piping, but it can't meet the DOT (Department of Transportation) standards for pressure on current transmission piping. And more advanced materials, such as the high-tech graphites and ceramics under scrutiny by the likes of the auto and aerospace industries, are still too expensive to be practical for pipelines. For years, natural gas carriers have used X60 or X65 grades of steel (indicating a yield strength of 60,000 or 65,000 pounds per square inch (psi), respectively). Gene Smith, chief engineer of metallurgy at MidCon Corp. and a member of A.G.A.'s Pipeline Research Committee, says that today, however, X70 is almost the norm. People see that if you use high-strength steel, you save weight. Forty percent of a pipeline construction budget typically goes for steel, so using less steel can show nice results on the bottom line. Pipeline engineers already are looking ahead to X80 steel. Because it is stronger, the walls of the pipe can be thinner, adding up to big savings over the length of a pipeline.
Drivers' Attitudes and Perceptions towards A Driving Automation System with Augmented Reality Human-Machine Interfaces. (2020)

Interaction research has been initially focusing on partially and conditionally automated vehicles. Augmented Reality (AR) may provide a promising way to enhance drivers' experience when using autonomous driving (AD) systems. This study sought to gain insights on drivers' subjective assessment of a simulated driving automation system with AR-based support. A driving simulator study was conducted and participants' rating of the AD system in terms of information imparting, nervousness and trust was collected. Cumulative Link Models (CLMs) were developed to investigate the impacts of AR cues, traffic density and intersection complexity on drivers' attitudes towards the presented AD system. Random effects were incorporated in the CLMs to account for the heterogeneity among participants. Results indicated that AR graphic cues could significantly improve drivers' experience by providing advice for their decision-making and mitigating their anxiety and stress. However, the magnitude of AR's effect was impacted by traffic conditions (i.e. diminished at more complex intersections). The study also revealed a strong correlation between self-rated trust and takeover frequency, suggesting takeover and other driving behavior need to be further examined in future studies.
An autosomal recessive <i>DNASE1L3</i> -related autoimmune disease with unusual clinical presentation mimicking systemic lupus erythematosus (2016)

We describe the third family in the world, after Arabian and Turkish ones, displaying an autosomal recessive autoimmune disease (AID), mimicking systemic lupus erythematosus (SLE), with unusual manifestations due to a homozygous frame-shift variant in DNASE1L3. SLE is a complex AID characterized by multiple organ involvement. Genetic risk variants identified account for only 15% of SLE heritability. Rare Mendelian forms have been reported, including DNASE1L3-related SLE. Through specific genetic tests we identified a homozygous 2 bp-deletion c.289_290delAC (NM_004944.2) in DNASE1L3, predicting frameshift and premature truncation (p.Thr97Ilefs*2). The same mutation was previously reported in three sisters, born from consanguineous parents and affected with hypocomplementemic urticarial vasculitis syndrome (HUVS). As approximately 50% of individuals affected with HUVS develop SLE, it is still unclear whether it is a SLE sub-phenotype or a separate condition.
Moving vehicle detection with convolutional networks in UAV videos (2016)

Moving vehicle detection from unmanned aerial vehicles (UAV) is becoming an increasingly important research topic in traffic monitoring, surveillance and military applications. Owing to the low-quality of UAV videos and the movement of the platform, vehicle detection is a challenging task. Existing algorithms that are generally designed for stationary cameras are ineffectively under this situation. This paper proposes an accurate moving vehicle detector. Significant contributions include a real-time, high detection rate approach for motion detection with image registration, candidate targets detection and vehicle screening using convolutional neural network. Experiments on a variety of data sets show the successful detection of moving vehicle under varying conditions. Currently the detection rate for vehicle is up to 90% and the average false alarm rate is less than 10%.
Pose measurement and tracking system for motion-correction of unrestrained small animal PET/SPECT imaging (2003)

An optical landmark-based pose measurement and tracking system is under development to provide in-scan animal position data for a new SPECT imaging system for unrestrained laboratory animals. The animal position and orientation data provides motion correction during image reconstruction. This paper describes new developments and progress using landmark markers placed on the animal along with strobed infrared lighting with improvements in accuracy for the extraction of head feature positions during motion. A stereo infrared imaging approach acquires images of the markers through a transparent enclosure, segments the markers, corrects for distortion and rejects unwanted reflections. Software estimates intrinsic as well as extrinsic camera calibration parameters and provides a full six degree-of-freedom (DOF) camera-to-camera calibration. A robust stereo point correspondence and 3D measurement calculation based on the fundamental matrix provides the pose at camera frame rates. Experimental testing has been conducted on calibrated fixtures with six DOF measurement capabilities as well as on live laboratory mice. Results show significantly improved accuracy and repeatability of the measurements. The live mouse results have demonstrated that reliable, accurate tracking measurements can be consistently achieved for the full SPECT image acquisition.
Long‐term efficacy and safety of ustekinumab, with and without dosing adjustment, in patients with moderate‐to‐severe psoriasis: results from the PHOENIX 2 study through 5 years of follow‐up (2014)

Treatment with ustekinumab for up to 5 years was safe and effective. Improved response was generally demonstrated following dosing adjustments; further investigations are required to quantify actual incremental benefits. The results also suggest that some patients may desire treatment goals beyond PASI 75.
The Café Coronary (1963)

A MIDDLE-AGED or elderly person, at a fashionable restaurant, is partaking of filet mignon, or perhaps broiled lobster or prime rib of beef. At the same time, he is conversing with companions at dinner. Suddenly, he ceases to eat and talk. The dinner companions are perplexed but not alarmed for there is no indication of distress. Then, the person suddenly collapses at the table. Attempts at resuscitation are made by the maitre d'hotel, waiters, and friends. In some instances, a physician may be present who also attempts to aid the stricken person. The ambulance arrives and the person is rushed to the nearest hospital emergency room where he is dead on arrival. The emergency room physician, or the family doctor, attributes death to natural causes and probably to coronary artery disease. The above is the characteristic story of death from asphyxiation due to occlusion of the airway by food. The
The new MATH: homology suggests shared binding surfaces in meprin tetramers and TRAF trimers (2002)

Although apparently functionally unrelated, intracellular TRAFs and extracellular meprins share a region with conserved meprin and traf homology, MATH(1). Both TRAFs and meprins require subunit assembly for function. By structural analysis of the sequences, we provide an explanation of how meprins, which form tetramers, and TRAF molecules, which form trimers, can share homology. Our analysis suggests it is highly likely that the same oligomerization surface is used. The analysis has implications for the widely distributed group of proteins containing MATH domains.
A 21ns 32K × 8 CMOS SRAM with a selectively pumped P-well array (1987)

A selectivity pumped P-well array used in a 32K×8 CMOS SRAM with a divided-word line block architecture to achieve a 21ns access time, will be described. The chip (6.83×8.97mm) was processed in a 1.2μm double-level metal, twin-well CMOS technology. Active power is 330mW at 22MHz.
Extending social marketing to emergency services organisations (2001)

Social marketing theory is examined in relation to an organisational context which has received little attention. This paper examines the development of an integrated social marketing campaign for a State Emergency Service, and focusses on a particularly serious scenario where the penalty for miscommunication may be death, widespead injury or substantial property damage. The researchers take an action research approach, identifying community perceptions of risk to determine appropriate communication message development. The study identifies the factors contributing to risk perception beyond traditional concepts of involvement which are common in studies of consumer behaviour. Additionally, this paper provides an investigation of some of the issues that affect communication effectiveness, such as the influence of stakeholders, the poor performance of traditional communications methods, the utility of social marketing principles, and segmentation requirements, as well as influential ideas from the general risk communication literature.
Fundamentals of multiplexing with digital PCR (2016)

Over the past decade numerous publications have demonstrated how digital PCR (dPCR) enables precise and sensitive quantification of nucleic acids in a wide range of applications in both healthcare and environmental analysis. This has occurred in parallel with the advances in partitioning fluidics that enable a reaction to be subdivided into an increasing number of partitions. As the majority of dPCR systems are based on detection in two discrete optical channels, most research to date has focused on quantification of one or two targets within a single reaction. Here we describe 'higher order multiplexing' that is the unique ability of dPCR to precisely measure more than two targets in the same reaction. Using examples, we describe the different types of duplex and multiplex reactions that can be achieved. We also describe essential experimental considerations to ensure accurate quantification of multiple targets.
Notizen: Zur Kenntnis von Erdalkali-tetraalkoxoboraten Me [B(OR)<sub>4</sub>]<sub>2</sub>. I. Methoxo-Verbindungen (1955)

Durch Einwirkung methylalkoholischer Lösungen von Borsäuretrimethylester auf Magnesium, Calcium, Strontium und Barium lassen sich gemäß Me + 2 ROH + 2 B(OR) 3 → Me[B(OR)4]2 + H 2 leicht Erdalkali-tetramethoxoborate Me[B(OR) 4 ] 2 gewinnen. Die farblosen, kristallinen Verbindungen sind in den gebräuchlichen organischen Lösungsmitteln außer Alkoholen unlöslich, zersetzen sich beim Erhitzen in Erdalkalialkoholat und Borsäureester und werden von Wasser nur langsam zu Erdalkalihydroxyd, Borsäure und Alkohol hydrolysiert. Ein Beryllium-tetramethoxoborat Be[B(OR) 4 ] 2 kann weder auf dem angegebenen Wege noch durch doppelte Umsetzung von Berylliumchlorid mit Natrium-tetramethoxoborat noch durch Methanolyse von Berylliumboranat erhalten werden, da selbst bei - 45° an seiner Stelle nur die Zerfallsprodukte Be(OR)2 und B(OR) 3 auftreten.
Invariant imbedding T matrix approach to electromagnetic scattering (1988)

A new method for calculating electromagnetic scattering from an arbitrarily shaped, inhomogeneous, dielectric object is developed. The method is based on an invariant imbedding procedure for computing the T matrix that was originally developed to solve quantum mechanical scattering problems. The final outcome of this approach is a two-term recurrence relation which can be solved numerically for the T matrix. The limiting form of this recurrence relation is a first-order nonlinear differential equation that is identical in form to the quantum mechanical Calogero equation. The results of several test calculations are also presented.
The effect of dynamic surface tension on nucleate boiling coefficients (1960)

Abstract A study was made of the effects the surface tension of aqueous solutions of surface‐active agents had on the bubble‐formation characteristics of these solutions. Bubbles were formed by two processes: by passing air through a horizontal orifice submerged in the solution and by nucleate boiling at an electrically heated surface. The experimental measurements taken with the air‐bubble system were used to determine the nature of the surface‐tension effect on air‐bubble formation. This knowledge was then applied to the interpretation of boiling measurements made with the same solutions. The boiling coefficients of the Tergitol‐water solution were found to vary inversely with dynamic surface tension. Boiling coefficients for Aerosol‐water solutions, however, varied in a manner which could not be related to surface‐tension effects.
The effects of emotional arousal and valence on television viewers’ cognitive capacity and memory (1995)

This study examines the combined effects of arousal and valence on viewers’ capacity allocation to and memory for television messages. Results show that when valence (how positive or negative a message is) is controlled, arousing messages are remembered better than calm messages. When arousal is controlled, positive messages are remembered better than negative messages. Reaction time results suggest that capacity allocation is a function of both valence and arousal. Viewers allocate the most capacity to positive arousing messages and the least capacity to negative arousing messages. The calm messages (both positive and negative) fall between these two.
Proteus mirabilis amino acid deaminase: cloning, nucleotide sequence, and characterization of aad (1995)

Proteus, Providencia, and Morganella species produce deaminases that generate alpha-keto acids from amino acids. The alpha-keto acid products are detected by the formation of colored iron complexes, raising the possibility that the enzyme functions to secure iron for these species, which do not produce traditional siderophores. A gene encoding an amino acid deaminase of uropathogenic Proteus mirabilis was identified by screening a genomic library hosted in Escherichia coli DH5 alpha for amino acid deaminase activity. The deaminase gene, localized on a cosmid clone by subcloning and Tn5::751 mutagenesis, was subjected to nucleotide sequencing. A single open reading frame, designated aad (amino acid deaminase), which appears to be both necessary and sufficient for deaminase activity, predicts a 473-amino-acid polypeptide (51,151 Da) encoded within an area mapped by transposon mutagenesis. The predicted amino acid sequence of Aad did not share significant amino acid sequence similarity with any other polypeptide in the PIR or SwissProt database. Amino acid deaminase activity in both P. mirabilis and E. coli transformed with aad-encoding plasmids was not affected by medium iron concentration or expression of genes in multicopy in fur, cya, or crp E. coli backgrounds. Enzyme expression was negatively affected by growth with glucose or glycerol as the sole carbon source but was not consistent with catabolite repression.
A flexible cold microplasma jet using biocompatible dielectric tubes for cancer therapy (2010)

This paper describes a flexible microplasma jet device using a Tygon® S-54-HL tube as a biocompatible tube and its potential in developing cancer therapies. The optical and physical properties of the plasma jets and preliminary apoptosis data of cultured murine tumor cells and nontumor fibroblast cells treated with these plasma jets are presented. Microplasma jets were observed to induce apoptosis in cultured murine cells in a dose-dependent manner. The murine melanoma tumor cells were more sensitive to plasma treatment than fibroblast cells. These features allow the direct and precise application of this microplasma jet device to tumor cells.
Nanostructured materials for selective recognition and targeted drug delivery (2005)

Selective recognition requires the introduction of a molecular memory into a polymer matrix in order to make it capable of rebinding an analyte with a very high specificity. In addition, targeted drug delivery requires drug-loaded vesicles which preferentially localize to the sites of injury and avoid uptake into uninvolved tissues. The rapid evolution of nanotechnology is aiming to fulfill the goal of selective recognition and optimal drug delivery through the development of molecularly imprinted polymeric (MIP) nanoparticles, tailor-made for a diverse range of analytes (e.g., pharmaceuticals, pesticides, amino acids, etc.) and of nanostructured targeted drug carriers (e.g., liposomes and micelles) with increased circulation lifetimes. In the present study, PLGA microparticles containing multilamellar vesicles (MLVs), and MIP nanoparticles were synthesized to be employed as drug carriers and synthetic receptors respectively.