gebhart/patrepeval huggingface dataset:
Silicon-photonic PTAT temperature sensor for micro-ring resonator thermal stabilization (2015)

We present a scheme for thermal stabilization of micro-ring resonator modulators through direct measurement of ring temperature using a monolithic PTAT temperature sensor. The measured temperature is used in a feedback loop to adjust the thermal tuner of the ring. The closed-loop feedback system is demonstrated to operate in presence of thermal perturbations at 20Gb/s.
Comparison of Quantitative Cytomegalovirus (CMV) PCR in Plasma and CMV Antigenemia Assay: Clinical Utility of the Prototype AMPLICOR CMV MONITOR Test in Transplant Recipients (2000)

The correlation between the prototype AMPLICOR CMV MONITOR test (Roche Molecular Systems), a quantitative PCR assay, and the cytomegalovirus (CMV) pp65 antigenemia assay was evaluated in transplant recipients. Sequential blood specimens were collected on 29 patients (491 specimens), the leukocyte fraction was tested by CMV antigenemia, and quantitative PCR was performed on plasma specimens. None of the 15 patients (242 specimens) who were antigenemia negative were positive for CMV DNA by PCR, and none of these patients developed active CMV disease. There were 14 antigenemia-positive patients, 8 of whom developed active CMV disease. In all patients, there was a good association between the antigenemia and PCR assays. Ganciclovir-resistant virus was isolated from three patients with active CMV disease. These three patients had persistently elevated levels of antigenemia and CMV DNA by PCR when resistance to ganciclovir developed. This standardized, quantitative CMV PCR assay on plasma has clinical utility for the diagnosis of active disease and in monitoring the response to antiviral therapy in transplant recipients.
Some factors affecting the self emulsification of hydrocarbon oils (2007)

Hydrocarbon oil-water interfacial tensions have been measured using the detachment of ring method for several systems containing mixtures of surfactants in the aqueous phase. From the plots of γo/w against the concentration of surfactants in solution, slopes i.e. dγ/d log C were determined and arranged in numerical order, the order indicating the magnitude of reduction in γo/w in the presence of the surfactants. The order was subsequently observed to be the same as the order of increasing degree or extent of self emulsification of each hydrocarbon employed. While studying phase formation when surfactants — hydrocarbon oil mixtures (i.e. three component systems) were added to increasing amounts of water (i.e. forming four component systems) it was observed that those systems which initially developed large quantities of liquid crystalline phases later formed better, finer emulsions than those systems that initially consisted of isotropic phases. These observations and their association with the process of self emulsification or easy emulsion formation in the systems investigated are presented in this report.
[Chemotherapy of resistant and recurrent lymphoma based on a combination of ifosfamide and etoposide. Antitumor effects, toxicity and stimulation of peripheral stem cells]. (1998)

Life saving regimes, VIM and MINE, have a good antilymphoma activity, low toxicity and in combination with growth factors (filgrastim) they ensure a good collection of PBSC. As compared with other regimens, in particular for stimulation, VIM and MINE appear to be better.
Use of Osmotic Pumps to Establish the Pharmacokinetic–Pharmacodynamic Relationship and Define Desirable Human Performance Characteristics for Aggrecanase Inhibitors (2016)

The development of reliable relationships between in vivo target engagement, pharmacodynamic activity, and efficacy in chronic disease models is beneficial for enabling hypothesis-driven drug discovery and facilitating the development of patient-focused candidate selection criteria. Toward those ends, osmotic infusion pumps can be useful for overcoming limitations in the PK properties of proof-of-concept (POC) compounds to accelerate the development of such relationships. In this report, we describe the application of this strategy to the development of hydantoin-derived aggrecanase inhibitors (eg, 3) for the treatment of osteoarthiritis (OA). Potent, selective inhibitors were efficacious in both chemical and surgical models of OA when exposures were sustained in excess of 10 times the plasma IC50. The use of these data for establishing patient-focused candidate selection criteria is exemplified with the characterization of compound 8, which is projected to sustain the desired level of target engagement at a dose of 45 mg qd.
Accuracy of Predicting the Genetic Risk of Disease Using a Genome-Wide Approach (2008)

This study advances the understanding of the relative power of case control and population studies of disease. The predictions represent an upper bound of accuracy which may be achievable with improved effect estimation methods. The formulae derived will help researchers determine an appropriate sample size to attain a certain accuracy when predicting genetic risk.
DER NEUE BRAKE ASSIST VON MERCEDES-BENZ - AKTIVE FAHRUNTERSTUETZUNG IN NOTSITUATIONEN - (1997)

Mercedes-Benz hat als weltweit erster Automobilhersteller ein elektronisch gesteuertes System zur Verkuerzung des Bremsweges in Notsituationen entwickelt. Das System, der Brake-Assist (BAS), gehoert seit Dezember 1996 bereits zur Serienausstattung der S-und SL-Klasse. Bis Mitte 1997 ist er auch in den anderen Pkws der Herstellerfirma serienmaessig enthalten. Der BAS baut schon am Beginn der Bremsung binnen Sekundenbruchteilen automatisch die maximale Bremskraftverstaerkung auf und verkuerzt daher den Anhalteweg erheblich. Im Beitrag werden die Ziele bei der Entwicklung des BAS erlaeutert. Ferner erfolgt eine Beschreibung des BAS und seiner Systemkomponenten. Nach Auffassung der Autoren kann der Brake Assist einen wesentlichen Beitrag zur Reduzierung der Unfallzahlen leisten. Er soll, nach einer Vorlaufzeit von einem Jahr, auch anderen Automobilherstellern angeboten werden. Titel in Englisch: The new brake assist of Mercedes-Benz - active driversupport in emergency braking situations.
Selective anodic oxidation of silicon in oxygen plasma (1980)

Plasma-enhanced oxidation process at low temperature was studied for the selective oxidation of silicon. Silicon dioxide films as thick as 1 µm were routinely obtained at the substrate temperature of 600 °C. The oxidation was found to proceed through the motion of both oxygen and silicon ions and/or their vacancies under the electric field applied across the oxide. Aluminum oxide film was used as a mask for selective oxidation and very small lateral oxidation under the mask was found. Furthermore, no generation of dislocations was found at mask edges. The properties of the oxide were found comparable to those of thermally grown oxide. Electron-spin resonance measurements revealed one kind of defects in the oxide, which was attributed to the interface states by comparing with results obtained by measuring the capacitance-voltage characteristics. The morphology of the Si-SiO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> interface, studied by transmission electron microscopy was not significantly different from that of thermally grown SiO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> -Si systems. Impurity redistribution in the substrate was not observed.
Good Vibrations: Tactile Feedback in Support of Attention Allocation and Human-Automation Coordination in Event-Driven Domains (1999)

Observed breakdowns in human-machine communication can be explained, in part, by the nature of current automation feedback, which relies heavily on focal visual attention. Such feedback is not well suited for capturing attention in case of unexpected changes and events or for supporting the parallel processing of large amounts of data in complex domains. As suggested by multiple-resource theory, one possible solution to this problem is to distribute information across various sensory modalities. A simulator study was conducted to compare the effectiveness of visual, tactile, and redundant visual and tactile cues for indicating unexpected changes in the status of an automated cockpit system. Both tactile conditions resulted in higher detection rates for, and faster response times to, uncommanded mode transitions. Tactile feedback did not interfere with, nor was its effectiveness affected by, the performance of concurrent visual tasks. The observed improvement in task-sharing performance indicates that the introduction of tactile feedback is a promising avenue toward better supporting human-machine communication in event-driven, information-rich domains.
Tapered fiber tips for fiber optic biosensors (1995)

Tapered fiber tips with different geometries are fabricated for developing a fiber optic biosensor. Fluorescence experiments are performed to compare the coupling efficiency of light for different fiber tip configurations. When light is generated in a "thick" layer (> 1 μm) around a fiber core, the continuously tapered tip with the steepest taper collects light more efficiently than the longer combination tapered tip. To demonstrate the applicability of our results, we have successfully detected weak chemiluminescent signal collected by a bundle of fibers with the short continuously tapered tips using a cooled CCD array detector. The chemiluminescence reaction was catalyzed by alkaline phosphatase immobilized on the fiber tips by a sol-gel technique.
Chemical decontamination of iPS cell-derived neural cell mixtures (2018)

This report describes the design and evaluation of phosphorylated 7-ethyl-10-hydroxycamptothecin (SN38-P), which selectively eliminates tumor-forming proliferative stem cells, including human induced pluripotent stem cells (hiPSCs) and neural stem cells, from iPSC-derived neural cell mixtures. Results of the present study demonstrate that simple phosphorylation of an anticancer drug can provide a safe, cost-effective, and chemically-defined tool for decontaminating hiPSC-derived neuron.
Lix(Mn1 − yCoy)O2 intercalation compounds as electrodes for lithium batteries: influence of ion exchange on structure and performance (2001)

LixMn1 − yCoyO2 compounds were synthesised by a low temperature route involving ion exchange from sodium precursors. Neutron diffraction confirmed that the structures are layered (space group Rm). Materials synthesised from the precursors by ion exchange using LiBr in ethanol at 80 °C possess vacancies on the transition metal sites which pin residual Na+ ions. Such transition metal vacancies and Na+ ions are not observed on refluxing at 160 °C in hexanol. We show that lithium intercalation accompanies the ion exchange process. The presence of Na+ in the Li+ layered materials induces disorder perpendicular to the layers and this has been modelled. The performance of the materials depends on the ion exchange conditions. The y = 0.025 compound obtained in ethanol exhibits a particularly high capacity to cycle lithium. The initial discharge capacity is 200 mA h g−1 with a fade rate of only 0.08% per charge/discharge cycle on extended cycling. This performance is delivered despite conversion to a spinel-like phase during cycling and is markedly superior to the cycling ability of directly prepared spinels over a similar composition range.
Combined effects of vasopressin V2 receptor antagonist and loop diuretic in humans (2003)

The co-administration may be particularly effective in treating edema and hyponatremia in edematous diseases.
A unified neural-network-based speaker localization technique (2000)

Locating and tracking a speaker in real time using microphone arrays is important in many applications such as hands-free video conferencing, speech processing in large rooms, and acoustic echo cancellation. A speaker can be moving from the far field to the near field of the array, or vice versa. Many neural-network-based localization techniques exist, but they are applicable to either far-field or near-field sources, and are computationally intensive for real-time speaker localization applications because of the wide-band nature of the speech. We propose a unified neural-network-based source localization technique, which is simultaneously applicable to wide-band and narrow-band signal sources that are in the far field or near field of a microphone array. The technique exploits a multilayer perceptron feedforward neural network structure and forms the feature vectors by computing the normalized instantaneous cross-power spectrum samples between adjacent pairs of sensors. Simulation results indicate that our technique is able to locate a source with an absolute error of less than 3.5 degrees at a signal-to-noise ratio of 20 dB and a sampling rate of 8000 Hz at each sensor.
Ultraviolet Absorption Cross Sections for the Alkali Halide Vapors (1967)

The ultraviolet-absorption cross sections for the alkali halide vapors were measured in the region from 2000 to 4000 Å. Potential curves were constructed from these data and are compared to some previous work. From the cross sections the radiative lifetime of the excited molecular states is calculated to be on the order of 10−8 sec.
Applications Of Pattern Classification To Time-Domain Signals (2010)

Many different kinds of physics are used in sensors that produce time-domain signals, such as ultrasonics, acoustics, seismology, and electromagnetics. The waveforms generated by these sensors are used to measure events or detect flaws in applications ranging from industrial to medical and defense-related domains. Interpreting the signals is challenging because of the complicated physics of the interaction of the fields with the materials and structures under study. often the method of interpreting the signal varies by the application, but automatic detection of events in signals is always useful in order to attain results quickly with less human error. One method of automatic interpretation of data is pattern classification, which is a statistical method that assigns predicted labels to raw data associated with known categories. In this work, we use pattern classification techniques to aid automatic detection of events in signals using features extracted by a particular application of the wavelet transform, the Dynamic Wavelet Fingerprint (DWFP), as well as features selected through physical interpretation of the individual applications. The wavelet feature extraction method is general for any time-domain signal, and the classification results can be improved by features drawn for the particular domain. The success of this technique is demonstrated through four applications: the development of an ultrasonographic periodontal probe, the identification of flaw type in Lamb wave tomographic scans of an aluminum pipe, prediction of roof falls in a limestone mine, and automatic identification of individual Radio Frequency Identification (RFID) tags regardless of its programmed code. The method has been shown to achieve high accuracy, sometimes as high as 98%.
Novel magnetic resonance technique for characterizing mesoscale structure of trabecular bone (2018)

Osteoporosis, characterized by increased fracture risk and bone fragility, impacts millions of adults worldwide, but effective, non-invasive and easily accessible diagnostic tests of the disease remain elusive. We present a magnetic resonance (MR) technique that overcomes the motion limitations of traditional MR imaging to acquire high-resolution frequency-domain data to characterize the texture of biological tissues. This technique does not involve obtaining full two-dimensional or three-dimensional images, but can probe scales down to the order of 40 μm and in particular uncover structural information in trabecular bone. Using micro-computed tomography data of vertebral trabecular bone, we computationally validate this MR technique by simulating MR measurements of a 'ratio metric' determined from a few <i>k</i>-space values corresponding to trabecular thickness and spacing. We train a support vector machine classifier on ratio metric values determined from healthy and simulated osteoporotic bone data, which we use to accurately classify osteoporotic bone.
Intracoronary adenosine administered during percutaneous intervention in acute myocardial infarction and reduction in the incidence of ?no reflow? phenomenon (2000)

Percutaneous intervention in acute myocardial infarction has been associated with a high incidence of "no reflow," ranging from 11% to 30%, with an increased risk of complications. The role of intracoronary adenosine for the prevention of this phenomenon has not been evaluated fully. We studied the procedural outcomes of 79 patients who underwent percutaneous intervention in the context of acute myocardial infarction. Twenty-eight patients received no intracoronary adenosine, and 51 received intracoronary adenosine boluses (24-48 microg before and after each balloon inflation). Eight patients who were not given adenosine experienced no reflow (28.6%) and higher rates of in-hospital death, while only three of 51 patients (5.9%; P = 0.014) in the adenosine group experienced no reflow. No untoward complications were noted during adenosine infusion. Intracoronary adenosine bolus administration during percutaneous intervention in the context of acute myocardial infarction is easy and safe and may significantly lessen the incidence of no reflow, which may improve the outcome of this procedure.
Class-based named entity translation in a speech to speech translation system (2008)

Named Entity (NE) Translation is a challenging problem in Machine Translation (MT). Most of the training bi-text corpora for MT lack enough samples of NEs to cover the wide variety of contexts NEs can appear in. In this paper, we present a technique to translate NEs based on their NE types in addition to a phrase-based translation model. Our NE translation model is based on a syntax-based system similar to [1]; but we produce syntax-based rules with non-terminals as NE types instead of general non-terminals. Such classbased rules allow us to better generalize the context NEs. We show that our proposed method obtains an improvement of 0.66 BLEU score absolute as well as 0.26% in F <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</inf> -measure over the baseline of phrase-based model in NE test set.
The Effect of Sorbic Acid on the Survival oOf Escherichia coli 0157:H7, Salmonella, Listeria monocytogenes, and Staphylococcus aureus on Shredded Cheddar and Mozzarella Cheese (2002)

The objective of this study was to determine the effectiveness of sorbic acid in inhibiting Escherichia coli 0157:H7, Salmonella spp., Listeria monocytogenes, and Staphylococcus aureus on shredded cheddar and mozzarella cheese over 70 days storage. Samples of cheese were inoculated and placed into bags with a sorbic acid (0, 0.1, 0.15, 0.2 and 0.3 %) and anti caking agent mixture and stored at 10 °C. Each variable was enumerated after 0,14,28,42,56, and 70 days of storage. Survival of E. coli 0157:H7 showed no significant difference from control in either cheese. There were significantly lower Salmonella counts for days 14 to 42 on mozzarella cheese. No significant differences in survival were found for cheddar cheese. There were significantly lower counts noted in L. monocytogenes, and S. aureus in mozzarella. Though no significant differences were found over time in the cheddar, most of the sorbate concentrations exhibited lower counts than control on days 14 and 28. Overall, in the presence of sorbic acid there was a more rapid decline in numbers of each test organism, especially against L. monocytogenes, and S. aureus for both high and low moisture cheeses.
Simulation-Based Hybrid-Electric Vehicle Design Search (1999)

<div class="htmlview paragraph">A computer simulation has been developed that models conventional, electric, and hybrid drivetrains. The vehicle's performance is predicted for a given driving cycle, such as the Federal Urban Driving Schedule (FUDS). This computer simulation was used in a massive designspace exploration to simulate 1.8 million different vehicles, including conventional, electric, and hybrid-electric vehicles (HEVs). This paper gives a description of the vehicle simulator as well as the results and implications of the large design-space exploration.</div>
Lifting and Sorting of Charged Au Nanoparticles by Electrostatic Forces in Atomic Force Microscopy (2010)

A new nanoparticle manipulation technique is demonstrated by application of electrostatic forces via the atomic force microscope (AFM) tip. Gold nanoparticles with a specific surface charge or mass could be selectively lifted up from a substrate by controlling the potential applied to the AFM tip.
Topical Application of JAK1/JAK2 Inhibitor Momelotinib Exhibits Significant Anti-Inflammatory Responses in DNCB-Induced Atopic Dermatitis Model Mice (2018)

Atopic dermatitis (AD) is a chronic recurrent skin disease dominated by T-helper 2 inflammation. Momelotinib (MMB) is a novel JAK1/JAK2 inhibitor suppressing the signal transduction of multiple pro-inflammatory cytokines. Recent studies indicated that JAK inhibitor could play a therapeutic role in AD disease. In this study, we evaluated the efficacy of MMB as a novel JAK1/JAK2 inhibitor in DNCB-induced AD mice and TSLP-activated dendritic cells. Our data showed that topical application of MMB reduced the skin severity scores and total serum IgE levels, and alleviated the histological indexes including epidermal thickness measurement and mast cell number. Also, it was demonstrated that MMB down-regulated the mRNA expression of IL-4, IL-5, IFN-γ and TSLP, and inhibited the phosphorylation of STAT1, STAT3 and STAT5 in skin lesions. Moreover, MMB reduced the expression of CD80, CD86, MHCII and mRNA of OX40L in TSLP-activated dendritic cells. In general, our study suggests that MMB can improve the symptoms of AD and topical application of MMB can become a promising new therapy strategy for AD.
Review of oximes available for treatment of nerve agent poisoning (1994)

A review was conducted of papers describing the use of N-methyl-2-pyridinealdoxime (PAM), toxogonin or HI-6 as antidotes to the nerve agents tabun, sarin, soman and VX. The review included use of the oxime alone, oxime plus atropine and oxime plus atropine plus diazepam, given therapeutically, i.e. after nerve agent, in all cases. Experiments with any of these compounds given prophylactically were not considered. The review also included protocols of pyridostigmine prophylaxis and oxime-atropine therapy (with or without diazepam). It was difficult to draw conclusions as to the best oxime to use, because of lack of data in many cases. The identity of the oxime did not appear to be important when pyridostigmine prophylaxis was combined with atropine-oxime-diazepam therapy; in these cases, very good protection was observed in guinea pigs against all four nerve agents. The choice of oxime based on the data presently available may well depend on factors other than protection against lethality, such as cost and availability of the oxime and human toxicity of the oxime. This last factor was also reviewed, and the results showed that toxogonin is likely to cause more side-effects than PAM or HI-6. The efficacy of the oximes against the emerging threat agent GF was also reviewed.