gebhart/patrepeval huggingface dataset:
Enabling Efficient Application Monitoring in Cloud Data Centers using SDN (2020)

Nowadays, many cloud applications can be considered large complex distributed services. The increasing sophistication and complexity have made performance monitoring a major issue and a critical process for both cloud providers and cloud customers. Existing monitoring techniques instrument the applications to collect measurements and log them at the host nodes on which the application is deployed. Such an approach introduces overhead and can slow down the application. New paradigms such as Software Defined Networking (SDN) and Network Function Virtualization (NFV) show promise for moving some of the measurement collection and logging functionality into the network as a lot of information can be extracted from messages exchanged between application components. Such a methodology could enable the cloud infrastructure to provide a Monitoring as a Service to applications in a transparent manner without software instrumentation and allowing for a more flexible placement of logging functionality. In this paper, we explore mechanisms to integrate application monitoring into SDN. In particular, we analyze whether switch based message filtering is feasible and we propose a customized port sniffing approach. We discuss the implementation aspects using OVS. The results confirm that moving application monitoring to the network is indeed an attractive option.
A novel DYRK1B inhibitor AZ191 demonstrates that DYRK1B acts independently of GSK3β to phosphorylate cyclin D1 at Thr286, not Thr288 (2013)

DYRK1B (dual-specificity tyrosine phosphorylation-regulated kinase 1B) is amplified in certain cancers and may be an oncogene; however, our knowledge of DYRK1B has been limited by the lack of selective inhibitors. In the present study we describe AZ191, a potent small molecule inhibitor that selectively inhibits DYRK1B in vitro and in cells. CCND1 (cyclin D1), a key regulator of the mammalian G1-S-phase transition, is phosphorylated on Thr(286) by GSK3β (glycogen synthase kinase 3β) to promote its degradation. DYRK1B has also been proposed to promote CCND1 turnover, but was reported to phosphorylate Thr(288) rather than Thr(286). Using in vitro kinase assays, phospho-specific immunoblot analysis and MS in conjunction with AZ191 we now show that DYRK1B phosphorylates CCND1 at Thr(286), not Thr(288), in vitro and in cells. In HEK (human embryonic kidney)-293 and PANC-1 cells (which exhibit DYRK1B amplification) DYRK1B drives Thr(286) phosphorylation and proteasome-dependent turnover of CCND1 and this is abolished by AZ191 or DYRK1B RNAi, but not by GSK3β inhibitors or GSK3β RNAi. DYRK1B expression causes a G1-phase cell-cycle arrest, but overexpression of CCND1 (wild-type or T286A) fails to overcome this; indeed, DYRK1B also promotes the expression of p21CIP1 (21 kDa CDK-interacting protein 1) and p27KIP1 (CDK-inhibitory protein 1). The results of the present study demonstrate for the first time that DYRK1B is a novel Thr(286)-CCND1 kinase that acts independently of GSK3β to promote CCND1 degradation. Furthermore, we anticipate that AZ191 may prove useful in defining further substrates and biological functions of DYRK1B.
INCREMENTAL TRANSITIVE DEPENDENCY TRACKING IN DISTRIBUTED COMPUTATIONS (1996)

The notion of causal dependency between events in distributed systems plays a central role in reasoning about distributed program behaviours [14]. Different techniques have been designed to track these dependencies during execution. We suggest a new incremental transitive dependency tracking technique. Once the transitive dependencies are recorded for an observable event, the dependency tracking cost can be reduced by propagating only future dependencies beyond that event. Furthermore, in contrast with the direct dependency tracking technique already proposed in the literature, our technique allows to compute the dependencies among an arbitrary subset of observable events. This gives an interesting filtering capability.
Polyamine compounds control cement fluid loss in freshwater or seawater slurries (1982)

A description is given of applications of polyamines in cement fluid loss control and defines some chemical parameters which determine the effectiveness of polyamine cement fluid loss control additives. A discussion is presented of types of polyamines available, effects of polymer types, and, applications. 14 refs.
yuan fa xing zhong shu shen jing xi tong e xing lin ba liu de zhen duan he zong he zhi liao (2013)

目的:总结原发性中枢神经系统恶性淋巴瘤的诊治经验,更好的为临床服务。方法:收集我院2011年1月~2013年2月诊治的10例原发性中枢神经系统淋巴瘤患者,所有患者均经CT及MRI检查,均发现颅内病灶,大部分肿瘤位于脑室周围,其形态多为类圆形,叶状较多。病灶大小:2~6cm,平均3.6cm,其中单发肿瘤9例,1例有3个病灶,MRIT1WI显示低和略低信号。10例患者均实施开颅手术,对病灶进行切除,并进行放射治疗。结果:本组10例患者经病理诊断为大B细胞型非霍奇金淋巴瘤,治疗后患者可以独自行走,临床症状明显好转。副反应:脱发8例,白细胞降低3例,恶心、呕吐4例,治疗结束后症状缓解。结论:CT及MRI是诊断原发性中枢神经系统淋巴瘤的重要手段,在手术治疗的基础上进行放疗和化疗,可以明显改善患者症状,提高临床疗效。
Rearrangement of Anilinomethylpyridines (1962)

Reaction of 1-[(2- and 4-pyridyl)methyl]pyridinium chloride and 1-[(6-methyl-2-pyridyl)methyl]pyridinium chloride with aniline hydrochloride was examined. The reaction at 140-150° resulted in formation of the corresponding anilino compounds and temperature above 200° afforded the rearrangement product of the former, p-aminobenzyl compound, while intermediate temperature gave a mixture of these two compounds. Rearrangement reaction of these 2- and 4-anilinomethylpyridine to 2- or 4-(p-aminobenzyl)pyridine was examined and it was found to be the result of an intermolecular reaction, differing in mechanism from that of Hofmann-Martius rearrangement reaction.
Potential mechanisms for cell-based gene therapy to treat HIV/AIDS (2014)

Hematopoietic stem cell-based gene therapy for HIV/AIDS may eventually become an alternative for standard ART and should ideally provide a functional cure in which the virus is durably controlled without medication. Recent results from preclinical research and early-stage clinical trials support the feasibility and safety of this novel strategy.
Transfer function measurement and analysis for a magnetic resonance imager (1991)

The transfer function characteristics of a 1.5T imager have been determined. An edge response function (ERF) was obtained from a water/Plexiglas interface at various pixel widths ranging from 0.312 to 1.0 mm. An SE pulse sequence was used with a 5-mm transaxial slice. The ERF was smoothed, differentiated, and Fourier transformed to obtain MTF curves. The LSF was analyzed for skewness and kurtosis. The area under the MTF amplitude curves and the equivalent bandpass were calculated. All ERFs, LSFs, and MTFs were well behaved. The resulting LSF was Gaussian. All calculated MTFs had cutoff frequencies slightly less than the theoretical Nyquist limit. The MTF calculated from the theoretical Gaussian LSF is slightly superior to that calculated from experimental data and provides an upper limit to the MTF. Spatial resolution in our MR imager is dominated by the pixel size via the Nyquist sampling theorem. System performance is slightly less than theoretically predicted, possibly due to image processing algorithms during the reconstruction process.
Flexible resource allocation scheme performance evaluation in EuroSkyWay multimedia satellite svstem (2002)

Advanced traffic management based on the Dynamic Resource Assignment allows a broadband satellite system such as EuroSkyWay (ESW) to dynamically assign the resources of connections. The mechanisms of the dynamic assignment exploit variations of Burstiness exhibited by real time and non real time Variable Bit Rate traffic sources to perform an optimised resource redistribution. The efficiency of the Dynamic Bandwidth Allocation Capability (DBAC) depends on the accuracy of the traffic source description; inaccurate assessment of the arrival process will cause an overhead and a degraded utilisation of system resources. In this paper simulated results about a flexible traffic burstiness predictor for dynamic bandwidth resource allocation based on neural network is presented. The approach is able to an online computation of expected resource request implementing traffic resource assignment by using a sub-symbolic adaptive representation of the traffic source.
“Click‐to‐Chelate”: Design and Incorporation of Triazole‐Containing Metal‐Chelating Systems into Biomolecules of Diagnostic and Therapeutic Interest (2008)

The site-specific conjugation of metal chelating systems to biologically relevant molecules is an important contemporary topic in bioinorganic and bioorganometallic chemistry. In this work, we have used the CuI-catalyzed cycloaddition of azides and terminal alkynes to synthesise novel ligand systems, in which the 1,2,3-triazole is an integral part of the metal chelating system. A diverse set of bidentate alkyne building blocks with different aliphatic and aromatic backbones and various donor groups were prepared. The bidentate alkynes were reacted with benzyl azide in the presence of a catalytic amount of CuI to form tridentate model ligands. The chelators were reacted with [ReBr3(CO)3]2- to form well-defined and stable complexes with different overall charges, structures and hydrophilicities. In all cases tridentate coordination of the ligands, including through N3 of the 1,2,3-triazole ring, was observed. The ligand systems could also be quantitatively radiolabelled with the precursor [99 mTc (H2O)3(CO)3]+ at low ligand concentrations. Similarly the alkynes were reacted with an azido thymidine derivative to form a series of compounds, which could be radiolabelled in situ to form single products. Subsequent incubation of the neutral and cationic organometallic 99 mTc thymidine derivatives with human cytosolic thymidine kinase, a key enzyme in tumour proliferation, revealed that only the neutral compounds maintained substrate activity towards the enzyme. Bioconjugation, radiolabelling and enzymatic reactions were successfully performed in a matter of hours. Thus, click chemistry provides an elegant method for rapidly functionalising a biologically relevant molecule with a variety of efficient metal chelators suitable for (radio)labelling with the M(CO)3 core (M=99 mTc, Re), to offer new potential for technetium-99 m in clinical and preclinical tracer development.
Quantifying and assessing biomechanical differences in swim turn using wearable sensors (2011)

The swim turn makes up a substantial portion of the total swim time in competition, and efficient turns can determine finishing positions in many competitions. Swim turns can be a neglected area of performance gain. This is largely due to the difficulty in extracting performance measures that might lead to improvement. An inertial sensor was used to assess the different phases of the swimming turn and the data were then compared to the synchronised video data. As a case study, two elite swimmers, a competitive pool swimmer and an elite Triathlete, were compared as a demonstration of the technology as a potential tool for routine use. The participants were asked to perform their typical tumble turn at two velocities. Timing of the rotation relative to the turn's push off was measured. The inertial sensor detected differences in rotation between the two swimmers tested. The sensor reported that push off occurred for the competitive swimmer before 90°and for the Triathlete after 90°of rotation and was confirmed by video footage.
Two-dimensional layered composite photocatalysts (2014)

Two-dimensional (2D) layered nanostructure composites are promising candidates for conducting high-performance energy conversion and environmental remediation. The construction of 2D layered composite photocatalysts can generate many unique properties that do not exist in other kinds of semiconductor composite photocatalyst, which are beneficial for photocatalytic performance enhancement, band gap tuning, heterojunction formation, etc. Recently, these advantages have greatly stimulated the study of 2D layered composite photocatalysts in the field of photocatalysis. This feature article summarizes the recent developments of 2D layered composite photocatalysts for photocatalytic applications, such as photocatalytic hydrogen production, bacterial disinfection, and pollutant degradation. Finally, perspectives on the challenges and opportunities for the future exploration of 2D layered composite photocatalysts are put forward.
Activation of PAD4 in NET formation (2012)

Peptidylarginine deiminases, or PADs, convert arginine residues to the non-ribosomally encoded amino acid citrulline in a variety of protein substrates. PAD4 is expressed in granulocytes and is essential for the formation of neutrophil extracellular traps (NETs) via PAD4-mediated histone citrullination. Citrullination of histones is thought to promote NET formation by inducing chromatin decondensation and facilitating the expulsion of chromosomal DNA that is coated with antimicrobial molecules. Numerous stimuli have been reported to lead to PAD4 activation and NET formation. However, how this signaling process proceeds and how PAD4 becomes activated in cells is largely unknown. Herein, we describe the various stimuli and signaling pathways that have been implicated in PAD4 activation and NET formation, including the role of reactive oxygen species generation. To provide a foundation for the above discussion, we first describe PAD4 structure and function, and how these studies led to the development of PAD-specific inhibitors. A comprehensive survey of the receptors and signaling pathways that regulate PAD4 activation will be important for our understanding of innate immunity, and the identification of signaling intermediates in PAD4 activation may also lead to the generation of pharmaceuticals to target NET-related pathogenesis.
Economic impact of preweaning vaccinations on health and performance of weaned feeder cattle (1997)

In October, 1995, 3,565 head of freshly weaned, British-breed calves were received into a weaning facility in southwest Nebraska. Calves were determined to be preconditioned if they had received both viral an d Pasteurella vaccines prior to weaning (PREWEAN; n = 2,315), and all other calves were considered to have no preconditioning (CRTL; n = 1,250). Cattle were processed within 24 hours of arrival, and booster vaccinations were given when appropriate. Average days on feed at the weaning facility were similar between PREWEAN and CTRL calves (52.4 and 50.3 days, respectively), but average daily gain (2.24 vs 1.87 kb) and cost per lb of gain ($.64 vs $.81) were improved (P<.01) for PREWEAN. Processing ($7.48 vs $9.10/hd) and medicine costs ($1.39 vs $5.27/hd) were lower (P<.01) for PREWEAN calves during the weaning phase. Only 10.6% of the PREWEAN calves were treated for sickness, whereas 34.7% of the CTRL calves were treated a t least once (P<.01). Mortality tended to be lower for PREWEAN calves compared to CTRL calves, although it was low for both groups (.26% v s .48%, respectively). The average total cost per head was similar for PREWEAN and CTRL calves ($73.62 vs $72.79, respectively). Theoretical breakevens reflected lower costs and increased performance in PREWEAN cattle . These results suggest that producers should get a return on their money invested in preconditioning programs that include protection against IBR, BVD, PI3, BRSV, and Pasteurella.
The synthesis of soluble, substituted silane high polymers by Wurtz coupling techniques (1991)

Abstract The Wurtz‐type coupling of a number of representative classes of substituted dichlorosilane monomers was investigated in considerable detail. Low temperature polymerization techniques, including ultrasonic activation, were also studied. Similarly, the effect of dipolar additives on the polymerization process was examined. The conclusions drawn from these studies provide some insight into the selection of useful polymerization conditions for the conversion of various monomer types into linear high polymers.
The Female of the Species: Baboon Mothers and a Courageous Career Move (2022)

Abstract Lucy Cooke celebrates the “fiercely analytical mind” of Jeanne Altmann, whose statistical work in the 1960s rescued animal mothers from evolutionary obscurity
A pilot study with monosialoganglioside GM1 on acute cerebral ischemia. (1990)

Reported here are the results of an open controlled study on the use of GM1 in cases of ischemic strokes in its acute phase. A statistically significant improvement was observed in cases treated with GM1 for neurological deficits (assessed by Mathew's rating scale, modified by Fritz-Werner) at 21, 60 and 120 days and for disability at 120 days.
Talk-back regulation: a regulatory response to the inhibitions of cell surface growth. (1989)

The net accumulation of RNA and protein was studied in exponentially growing cultures of Streptococcus rattus FA-1 (formerly S. mutans FA-1) during periods of antibiotic induced inhibition of cell surface growth. Disruption of either the cytoplasmic, membrane, or final assembly steps of peptidoglycan (PG) synthesis following exposure of cultures to D-cycloserine plus beta-chloro-D-alanine (CS-CA), vancomycin (Vanco) or benzylpenicillin (Pen G) respectively, was accompanied by a rapid inhibition of RNA accumulation followed by an inhibition of protein accumulation. At physiologically comparable concentrations, CS-CA and Vanco inhibited RNA more efficiently than Pen G. CS-CA inhibited RNA and PG to the same degree while RNA accumulation was clearly more sensitive to Vanco than was PG. Simultaneous treatment with chloramphenicol (CAP), relaxed the cell wall antibiotic induced inhibition of RNA to a degree and with kinetics similar to those observed during CAP relaxation of the stringent response in amino acid deprived cultures. The degree of survival following exposure to the PG inhibitors varied directly with the efficiency of the antibiotics to inhibit RNA accumulation. CAP and tetracycline acted synergistically with CS-CA and to a lesser degree with Vanco while marginally antagonizing the killing effects of Pen G. On the basis of these and other observations it is proposed that the assembly status of the cell wall can be communicated, i.e. 'talk back', to the cytoplasmic processes of macromolecular synthesis via a specific regulatory type circuit. The efficiency of induction of the talk-back response appears to be directly related to survival.
Leveraging Web-Based Information Systems (1999)

Abstract Internet technologies, including the Web, Web browsers, and search engines, have provided unprecedented opportunities for conducting business online. Together, these technologies enable the creation of Web-based information systems, which are changing market dynamics and the way companies conduct business. This article presents a framework for an internetworked business model using Web-based information systems.
THE DISTRIBUTION OF BUOYANT DENSITY OF HUMAN ERYTHROCYTES IN BOVINE ALBUMIN SOLUTIONS (1964)

NOTE: Text or symbols not renderable in plain ASCII are indicated by [...]. Abstract is included in .pdf document. A procedure for preparing and fractionating linear density gradients of bovine serum albumin is described. Reproducible buoyant density distributions of human erythrocytes in these gradients were obtained and individual fractions could be rebanded. The average buoyant density of erythrocytes from four individuals was 1.0808 [plus or minus] 0.0004 g. cm.[superscript -3]; the average density from a fifth individual was 0.0028 g. cm.[superscript -3] greater. The entire buoyant density distribution shifts with salt content; the erythrocytes behave as "perfect" osmometers. Salt gradients predictably spread or narrow the distribution, and may be used to increase the resolving power of the density gradient. Rabbit erythrocytes pulse-labeled with Fe[superscript 59] first appear at the light edge of the distribution, and the mean progresses linearly with time through the distribution. The width of the distribution of labeled cells also increases with time. A study with the Coulter-Counter Model B of cell volumes in the buoyant density fractions showed that the mean cell volumes on the lighter side remained constant, while on the dense side the mean cell volume decreases. This decrease, if regarded as a water loss, does not quantitatively account for the increase in density. Microscopic examination of the individual fractions of the buoyant density distribution show that the cells do not appear to be damaged by the manipulations, and that cells in the denser fractions are significantly less biconcave than the average cell. The reticulocytes concentrate in the lighter fractions, but do not clearly separate from the erythrocytes. It is proposed that the buoyant density be regarded as an index of the physiological condition of the erythrocyte. A summary discussion of the aging of the erythrocyte is given.
An X-linked Gene Encodes a Major Human Sperm Fibrous Sheath Protein, hAKAP82 (1998)

Mammalian sperm motility is regulated by a cascade of cAMP-dependent protein phosphorylation events mediated by protein kinase A. A-kinase anchor proteins (AKAPs) direct protein kinase A activity by tethering the enzyme near its physiological substrates. We have characterized a major human sperm fibrous sheath AKAP, hAKAP82, and its precursor, pro-hAKAP82, the homologues of the mouse fibrous sheath proteins mAKAP82 and pro-mAKAP82. The cDNA sequence of pro-hAKAP82 was highly homologous to the mouse sequence, and the functional domains of the pro-hAKAP82 protein, the protein kinase A binding, and the pro-hAKAP82/hAKAP82 cleavage sites were identical to those of the mouse protein. The genomic organization of mouse pro-AKAP82 was determined. Alternative splicing occurred in both the mouse and human pro-AKAP82 genes that resulted in at least two distinct transcripts and possibly two different proteins. Compared with pro-mAKAP82, considerably less pro-hAKAP82 was processed to hAKAP82 in human sperm. Although pro-mAKAP82 localizes only to the proximal portion of the principal piece of the flagellum, pro-hAKAP82 localized to the entire length of the principal piece. The pro-hAKAP82 gene mapped to human chromosome Xp11.2, indicating that defects in this gene are maternally inherited. These studies suggest several roles for hAKAP82 in sperm motility, including the regulation of signal transduction pathways.
Current control techniques for three-phase voltage-source PWM converters: a survey (1998)

The aim of this paper is to present a review of current control techniques for three-phase voltage-source pulsewidth modulated converters. Various techniques, different in concept, have been described in two main groups: linear and nonlinear. The first includes proportional integral (stationary and synchronous) and state feedback controllers, and predictive techniques with constant switching frequency. The second comprises bang-bang (hysteresis, delta modulation) controllers and predictive controllers with on-line optimization. New trends in current control-neural networks and fuzzy-logic-based controllers-are discussed, as well. Selected oscillograms accompany the presentation in order to illustrate properties of the described controller groups.
Wide-angle achromatic prism beam steering for infrared countermeasure applications (2003)

The design and analysis of achromatic doublet prisms for use in laser beam steering is presented. The geometric relationships describ- ing the maximum steering angle are given, as are discussions of first- and second-order dispersion reduction. Infrared (IR) material alterna- tives and optimum IR material characteristics for wide-angle achromatic prism beam steering are also investigated. Sixteen materials in 120 dif- ferent combinations have been examined to date. For midwave IR appli- cations it is shown that the minimum dispersion currently achievable across the full 2 to 5 mm spectrum is 1.7816 mrad at an average maxi- mum steering angle of 45 deg. This is accomplished using LiF/ZnS dou- blet prisms. Several issues related to the azimuth and elevation angles into which light is steered as a function of prism rotation angles are also presented. © 2003 Society of Photo-Optical Instrumentation Engineers.