gebhart/patrepeval huggingface dataset:
Evaluation of a Sol-Gel Derived Nafion/Silica Hybrid Membrane for Polymer Electrolyte Membrane Fuel Cell Applications: II. Methanol Uptake and Methanol Permeability (2001)

Sol-gel derived Nafion/silica hybrid membranes were investigated as a potential polymer electrolyte for direct methanol fuel cell applications. Methanol uptake and methanol permeability were measured in liquid and vapor phase as a function of temperature, methanol vapor activity, and silica content. Decreased methanol uptake from liquid methanol was observed in the hybrid membranes with silica contents of 10 and 21 wt %. The hybrid membrane with silica content of ≈20 wt % showed a significant lower methanol permeation rate when immersed in a liquid methanol-water mixture at 25 and 80°C. Methanol uptake from the vapor phase by the hybrid membranes appears similar to that of unmodified Nafion. Methanol diffusion coefficients, as determined from sorption experiments, were slightly lower in the hybrid membranes than in unmodified Nafion. However, in direct permeation experiments, significantly lower methanol vapor permeability was seen only in the hybrid membrane with silica content of ≈20 wt %. Based on these results, Nafion/silica hybrid membranes with high silica content have potential as electrolytes for direct methanol fuel cells operating either on liquid or vapor-feed fuels. © 2001 The Electrochemical Society. All rights reserved.
Design, Synthesis, and Binding Affinities of Potential Positron Emission Tomography (PET) Ligands for Visualization of Brain Dopamine D<sub>3</sub>Receptors (2005)

We here report the synthesis of compounds structurally related to the high-affinity dopamine D(3) receptor ligand N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]-7-methoxy-2-benzofurancarboxamide (1). All compounds were specifically designed as potential PET radioligands for brain D(3) receptors visualization, having lipophilicity within a range for high brain uptake and weak nonspecific binding (2 < ClogP < 3.5) and bearing a methoxy substituent for easy access to labeling with the positron emitter isotope (11)C. N-[4-[4-(5-methoxy-2-benzisoxazolyl)piperazin-1-yl]butyl]-4-(4-morpholinyl)benzamide (22), N-[4-[4-(5-methoxy-2-benzisoxazolyl)piperazin-1-yl]butyl]-4-(1H-imidazol-1-yl)benzamide (23), and N-[4-[4-(5-methoxy-2-benzisoxazolyl)piperazin-1-yl]butyl]-5-(2-furanyl)-1H-pyrazole-3-carboxamide (24) displayed good D(3) receptor affinities (K(i) values 38.0, 22.6, and 21.3 nM, respectively) and were selective over D(2) receptor. Moreover, compounds 22-24 were able to permeate the Caco-2 cell monolayer, differently from compound 1. Although the goal to identify potential PET radioligands with subnanomolar affinities for D(3) receptor was not achieved, the proposed strategy could be a starting point for future developments.
The effects of chemical doping with F<sub>4</sub>TCNQ in carbon nanotube field-effect transistors studied by the transmission-line-model technique (2007)

We have studied the effects of p-type chemical doping with F4TCNQ (tetrafluorotetracyano-p-quinodimethane) in carbon nanotube field-effect transistors (CNFETs). The transmission-line-model technique using multi-probe CNFETs has been employed to investigate the effects of chemical doping on the channel resistance and contact resistance. It has been found that chemical doping is effective in the reduction of the contact resistance as well as the channel resistance. The device performances of top-gate CNFETs such as transconductance, on-resistance, and on/off ratio were improved by the F4TCNQ chemical doping on the access regions.
Genome-wide discovery and characterization of maize long non-coding RNAs (2014)

We integrate all available transcriptomic datasets to identify a comprehensive set of maize lncRNAs, provide a unique annotation resource of the maize genome and a genome-wide characterization of maize lncRNAs, and explore the genetic control of their expression using expression quantitative trait locus mapping.
Dispersion and Stabilization of Photocatalytic TiO<sub>2</sub> Nanoparticles in Aqueous Suspension for Coatings Applications (2012)

To produce titanium dioxide (TiO 2 ) nanoparticle coatings, it is desirable that the nanoparticles are dispersed into a liquid solution and remain stable for a certain period of time. Controlling the dispersion and aggregation of the nanoparticles is crucial to exploit the advantages of the nanometer‐sized TiO 2 particles. In this work, TiO 2 nanoparticles were dispersed and stabilized in aqueous suspensions using two common dispersants which were polyacrylic acid (PAA) and ammonium polymethacrylate (Darvan C). The effect of parameters such as ultrasonication amplitude and type and amount of dispersants on the dispersibility and stability of the TiO 2 aqueous suspensions were examined. Rupture followed by erosion was determined to be the main break up mechanisms when ultrasonication was employed. The addition of dispersant was found to produce more dispersed and more stabilized aqueous suspension. 3 wt.% of PAA with average molecular weight ( M w ) of 2000 g/mol (PAA 2000) was determined to produce the best and most stable dispersion. The suspensions were then coated on quartz glass, whereby the photocatalytic activity of the coatings was studied via the degradation of formaldehyde gas under UV light. The coatings were demonstrated to be photocatalytically active.
Role of Vma21p in Assembly and Transport of the Yeast Vacuolar ATPase (2004)

The Saccharomyces cerevisiae vacuolar H+-ATPase (V-ATPase) is a multisubunit complex composed of a peripheral membrane sector (V1) responsible for ATP hydrolysis and an integral membrane sector (V0) required for proton translocation. Biogenesis of V0 requires an endoplasmic reticulum (ER)-localized accessory factor, Vma21p. We found that in vma21Delta cells, the major proteolipid subunit of V0 failed to interact with the 100-kDa V0 subunit, Vph1p, indicating that Vma21p is necessary for V0 assembly. Immunoprecipitation of Vma21p from wild-type membranes resulted in coimmunoprecipitation of all five V0 subunits. Analysis of vmaDelta strains showed that binding of V0 subunits to Vma21p was mediated by the proteolipid subunit Vma11p. Although Vma21p/proteolipid interactions were independent of Vph1p, Vma21p/Vph1p association was dependent on all other V0 subunits, indicating that assembly of V0 occurs in a defined sequence, with Vph1p recruitment into a Vma21p/proteolipid/Vma6p complex representing the final step. An in vitro assay for ER export was used to demonstrate preferential packaging of the fully assembled Vma21p/proteolipid/Vma6p/Vph1p complex into COPII-coated transport vesicles. Pulse-chase experiments showed that the interaction between Vma21p and V0 was transient and that Vma21p/V0 dissociation was concomitant with V0/V1 assembly. Blocking ER export in vivo stabilized the interaction between Vma21p and V0 and abrogated assembly of V0/V1. Although a Vma21p mutant lacking an ER-retrieval signal remained associated with V0 in the vacuole, this interaction did not affect the assembly of vacuolar V0/V1 complexes. We conclude that Vma21p is not involved in regulating the interaction between V0 and V1 sectors, but that it has a crucial role in coordinating the assembly of V0 subunits and in escorting the assembled V0 complex into ER-derived transport vesicles.
Myocardial protection with preconditioning. (1990)

Myocardial preconditioning with brief coronary artery occlusions before a sustained ischemic period is reported to reduce infarct size. To determine the number of occlusive episodes required to produce the preconditioning effect, we performed single or multiple occlusions of the left circumflex coronary artery (LCx) followed by a sustained occlusion (60 minutes) of the LCx. Anesthetized dogs underwent one (P1), six (P6), or 12 (P12) 5-minute occlusions of the LCx. Each occlusion period was followed by a 10-minute reperfusion period. A 60-minute occlusion of the LCx followed the preconditioning sequences. A control group received a 60-minute occlusion of the LCx without preconditioning. All groups were subjected to 6 hours of reperfusion after which the heart was removed for calculating infarct size (IS), area at risk (AR), and left ventricular mass (LV). The IS/AR ratio for the control group was 29.8 +/- 4.4% (n = 17), which was substantially greater (p less than 0.001) than that of the preconditioned groups: P1, 3.9 +/- 1.3% (n = 14); P6, 0.4 +/- 0.3% (n = 5); and P12, 2.9 +/- 2.8% (n = 5). There were no significant differences in the IS/AR ratio among the three preconditioned groups. The AR/LV ratio was comparable among all groups and did not differ statistically: control, 40.4 +/- 1.3%; P1, 36.2 +/- 1.7%; P6, 36.1 +/- 1.7%; and P12, 37.3 +/- 2.1%. Collateral blood flow to the inner two thirds of the risk region determined with radiolabeled microspheres during ischemia did not differ significantly between the control group (0.03 +/- 0.01 ml/min/g, n = 8) and single occlusion group (0.06 +/- 0.02 ml/min/g, n = 8), indicating that the marked disparity in infarct size could not be attributed to differences in collateral blood flow. The data indicate that preconditioning with one brief ischemic interval is as effective as preconditioning with multiple ischemic periods.
Structure of Semidilute Single-Wall Carbon Nanotube Suspensions and Gels (2006)

The microscopic network structure of surfactant-stabilized single-wall carbon nanotubes (SWNTs) in water was investigated as a function of SWNT concentration in the semidilute (overlapping) regime using small-angle neutron scattering (SANS). Most of the samples exhibit rigid rod behavior (i.e., Q(-1) intensity variation) at large scattering wavevector, Q, and a crossover to network behavior (i.e., approximately Q(-2) intensity variation) at low Q. The mesh size, xi, of the network was determined from the crossover of rigid rod to network behavior in the SANS intensity profile and was found to decrease with increasing SWNT concentration. When the dispersion quality of these associating rigid rods was degraded, only approximately Q(-2) intensity variation was observed at both high and low Q. Small-angle X-ray scattering measurements of the same stable dispersions were relatively insensitive to network structure because of poor contrast between SWNTs and surfactant.
Retrograde access of the left atrium for pulmonary vein isolation using magnetic navigation after closure of an atrial septum defect (2015)

Transseptal puncture is the most commonly used technique to perform electrophysiological procedures in the left atrium. This case report describes a pulmonary vein isolation in a patient with a paroxysmal atrial fibrillation, complicated by the presence of an oversized Amplatzer device (AGA Medical Corp., Golden Valley, MN). A retrograde approach using the magnetic navigation system (Niobe, Stereotaxis Inc., St Louis, USA) was performed, and showed to provide a feasible, safe and successful alternative for catheter ablation of cardiac arrhythmias in patients in whom the classic transseptal approach is impossible.
PID gain tuning based on falsification using bandpass filters (2006)

A data-driven model-free design method of PID gains has been developed based on unfalsified control for a mixed sensitivity control problem. PID gains can be falsified effectively by this method if many sinusoidal responses are used. However, this requires many experiments. In this paper, we propose a method of generating such data that efficiently falsify PID gains by filtering the input output data with many bandpass filters. By this method, PID gains can be falsified effectively from a step response data of a closed-loop system
Internet for Windows: The Microsoft Network Edition (1995)

Offers information on using the network, discussing e-mail, Internet discussion groups, and conducting research.
Vascular endothelial growth factor production in normal epidermis and in benign and malignant epithelial skin tumors. (1996)

Vascular endothellal growth factor (VEGF) increases vascular permeability and acts as a mitogen for endothelial cells in vivo and in vitro. We and others recently demonstrated that cultured human keratinocytes constitutively secrete VEGF. In the present study, we examined the expression of this growth factor in various epithelial skin tumors and in normal skin. Using in situ hybridization, we detected strong VEGF mRNA expression in all of 10 squamous cell carcinomas, 13 common warts, 11 seborrheic keratoses, and in 7 of 8 keratoacanthomas studied. By contrast, we found no VEGF mRNA in 9 of 14 basal cell carcinomas. VEGF mRNA was readily detectable within the epidermis adjacent to the tumors as well as in tumor cells and in the epidermis of normal human skin. Northern hybridization of RNA derived from normal human epidermis identified VEGF transcripts of 3.7 and 1.8 kb, and reverse transcriptase polymerase chain reaction confirmed that epidermal cells, like keratinocytes in vitro, express the three major splice forms of VEGF. Immunohistochemical staining with monoclonal antibodies confirmed that expression of VEGF mRNA was accompanied by the presence of VEGF protein. Our data demonstrate that VEGF production by tumor cells in situ does not distinguish malignant from benign epithelial tumors of the skin because it is present in both. The constitutive expression of VEGF by normal keratinocytes in situ suggests that this angiotropic cytokine is important for the regulation of vessel function under physiologic conditions.
Rapid Stereoselective Hydrolysis of (+)‐Cocaine in Baboon Plasma Prevents Its Uptake in the Brain: Implications for Behavioral Studies (1990)

The naturally occurring enantiomer of cocaine, (-)-cocaine, has been previously labeled with 11C on the N-methyl group and used in conjunction with positron emission tomography to show that cocaine is rapidly taken up in the striata of human and baboon brain. In the present study, the behaviorally inactive (+)-cocaine was similarly labeled, with a view to its use for measuring the nonspecific binding of cocaine. No brain uptake was seen, although transport of cocaine into the brain is not expected to be stereoselective. The explanation for the lack of uptake was determined to be very rapid metabolism of (+)-cocaine in the blood. By 30 s after administration of labeled (+)-cocaine, it was undetectable in plasma. In vitro studies demonstrated that (+)-cocaine is 50% debenzoylated to (+)-ecgonine methyl ester within 5 s of exposure to baboon plasma but not to washed erythrocytes. The hydrolysis of (-)-cocaine is at least 1,000 times slower. Serum butyrylcholinesterase (EC 3.1.1.8) appears to be responsible for this hydrolysis, as evidenced by its inhibition by physostigmine and catalysis by commercially available pseudocholinesterase from horse and human blood.
A New Autonomous Component Carrier Selection Scheme for Home eNB in LTE-A System (2011)

Dynamic frequency management is considered to be beneficial for the uncoordinated self-deployment of Home eNB (HeNB) in LTE-A heterogeneous networks. In this paper, a new autonomous component carrier (CC) selection scheme is proposed that dynamically selects the CC with efficient inter-cell signaling design. The CC selection criterion is to minimize the interference contribution composed of the incoming and outgoing interference. Additionally, power control and weighted proportional fair (PF) scheduling are used to further improve the cell-edge performance. The proposed inter-cell signaling between HeNBs is independent of CC number, user number and CC allocation results in HeNB network, thus the inter-cell signaling overhead can be greatly reduced. Simulation results show that the proposed CC selection scheme can autonomously achieve high cell-average and cell-edge throughput. This distributed and adaptive scheme performed locally at each HeNB is suitable for the uncoordinated HeNB deployment without centralized control unit.
The role of protein kinase C in the synergistic interaction of safingol and irinotecan in colon cancer cells (2009)

Colon cancer represents one of the most common solid tumors in adults. Although 5-fluorouracil (5-FU) and irinotecan have been frequently administered in colon cancer patients, low response rates to these single drug therapies were reported. It is therefore imperative to search for new targeted combination therapies that are effective. In this study, we investigated the anti-cancer effect of safingol as a single agent or in combination with irinotecan using HT-29 and LS-174T colon cancer cells as our in vitro models. As a single agent, safingol was more potent than irinotecan and 5-FU, with IC50 values of 2.5+/-1.1 microM and 3.4+/-1.0 microM achieved in HT-29 and LS-174T cells, respectively. However, protein kinase C (PKC) was not inhibited with concentrations of safingol which could induce substantial cell kill. The combination of safingol/irinotecan at 1:1 molar ratio was found to be additive in HT-29 cells (CI=0.94) and synergistic in LS-174T cells (CI=0.68), and resulted in concentration- and time-dependent down-regulation of p-PKC and p-MARCKS. The drug effect of the safingol/irinotecan combination was further modulated in the presence of a PKC stimulator (phorbol 12-myristate 13-acetate) or a PKC inhibitor (staurosporine). Furthermore, the 1:1 safingol/irinotecan combination inhibited the adhesion of colon cancer cells to the extracellular matrix 4-h post-treatment. Taken together, modulation of the PKC pathway could be a possible molecular basis for the observed synergism of the safingol/irinotecan combination, and these results demonstrate the therapeutic potential of this drug combination in colon cancer treatment.
A Motif in the Clathrin Heavy Chain Required for the Hsc70/Auxilin Uncoating Reaction (2007)

The 70-kDa heat-shock cognate protein (Hsc70) chaperone is an ATP-dependent "disassembly enzyme" for many subcellular structures, including clathrin-coated vesicles where it functions as an uncoating ATPase. Hsc70, and its cochaperone auxilin together catalyze coat disassembly. Like other members of the Hsp70 chaperone family, it is thought that ATP-bound Hsc70 recognizes the clathrin triskelion through an unfolded exposed hydrophobic segment. The best candidate is the unstructured C terminus (residues 1631-1675) of the heavy chain at the foot of the tripod below the hub, containing the sequence motif QLMLT, closely related to the sequence bound preferentially by the substrate groove of Hsc70 (Fotin et al., 2004b). To test this hypothesis, we generated in insect cells recombinant mammalian triskelions that in vitro form clathrin cages and clathrin/AP-2 coats exactly like those assembled from native clathrin. We show that coats assembled from recombinant clathrin are good substrates for ATP- and auxilin-dependent, Hsc70-catalyzed uncoating. Finally, we show that this uncoating reaction proceeds normally when the coats contain recombinant heavy chains truncated C-terminal to the QLMLT motif, but very inefficiently when the motif is absent. Thus, the QLMLT motif is required for Hsc-70-facilitated uncoating, consistent with the proposal that this sequence is a specific target of the chaperone.
Sleep Timing and Circadian Phase in Delayed Sleep Phase Syndrome (2009)

Delayed sleep phase syndrome (DSPS) is a circadian rhythm sleep disorder in which the timing of the sleep episode occurs later than desired and is associated with difficulty falling asleep, problems awakening on time (e.g., to meet work or school obligations), and daytime sleepiness. The phase relationship between the timing of sleep and endogenous circadian rhythms is critical to the initiation and maintenance of sleep, and significant alteration leads to impairment of sleep quality and duration. The aim of this retrospective study was to determine the phase relationship between sleep-wake times and physiological markers of circadian timing in clinic patients with DSPS. Objective and subjective measures of sleep timing and circadian phase markers (core body temperature and melatonin) were measured in patients with DSPS and compared with age-matched controls. As expected, significant delays in the timing of the major sleep episode and circadian phase of body temperature and melatonin rhythms were seen in the DSPS group when allowed to sleep at their own habitual schedules, but the phase relationship between sleep-wake times and circadian phase was similar between the 2 groups. These results suggest that the symptoms of insomnia and excessive daytime sleepiness in DSPS patients living under entrained real-life conditions cannot be explained by an alteration in the phase relationship between sleep-wake patterns and other physiological circadian rhythms.
On the synthesis of equivalent-circuit models for multiports characterized by frequency-dependent parameters (2002)

The synthesis of lumped-element equivalent circuits for time-domain analysis of problems with frequency-dependent parameters is of great interest in microwave theory. This paper presents a systematic approach to generate minimal-order realizations for passive microwave circuits characterized by either admittance, impedance, or scattering-parameter data. In addition, a very efficient method to ensure inherent system properties such as stability and passivity is described. The proposed method is suitable for simulating frequency-response-based linear subnetworks in a general circuit environment consisting of lumped/distributed elements and nonlinear devices. Modeling examples for a two-, four-, and ten-port system with nonlinear and linear terminations, respectively, are given.
Influence of Factor VIIa and Phospholipids on Coagulation in “Acquired” Hemophilia (2003)

The influence of rFVIIa is dependent on TF, and phospholipids substantially increase the hemostatic (or thrombotic) potential of rFVIIa/TF.
Experimental quantum cryptography: the dawn of a new era for quantum cryptography: the experimental prototype is working] (1989)

article Experimental quantum cryptography: the dawn of a new era for quantum cryptography: the experimental prototype is working] Share on Authors: C. H. Bennett IBM T . J . Watson Research, Laboratory, Yorktown Heights, New York, NY IBM T . J . Watson Research, Laboratory, Yorktown Heights, New York, NYView Profile , G. Brassard Département I. R. 0., Université de Montréal, C.P. 6128, Succ . "A", Montréal (Quebec), CANADA H3C 3J7 Département I. R. 0., Université de Montréal, C.P. 6128, Succ . "A", Montréal (Quebec), CANADA H3C 3J7View Profile Authors Info & Claims ACM SIGACT NewsVolume 20Issue 4Nov. 1989 pp 78–80https://doi.org/10.1145/74074.74087Online:01 November 1989Publication History 87citation1,222DownloadsMetricsTotal Citations87Total Downloads1,222Last 12 Months131Last 6 weeks9 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Application classification in cellular backhaul networks (2011)

Cellular backhaul networks carry user's traffic within encrypted tunnels. With tunneled traffic, the application classifier cannot identify the underline TCP/UDP connections and cannot use any IP packet header information. Yet, some statistical properties can be considered in this case too, such as: volume per tunnel, tunnel durations, inter-packets delays (however, sequential packets might belong to different TCP connections), packet sizes, and packet direction. This research deals with blind classification of the dominated application of user tunneled traffic into 4 classes: (1) Control, VoIP and IM; (2) Video streaming; (3) Web browsing; and (4) file download/sharing. Our experimental results show that such a blind on-line classifier can classify the dominated application of a user tunnel into these four classes with more than 80% accuracy.