gebhart/patrepeval huggingface dataset:
Lentiviral expression of GAD67 and CCK promoter-driven opsins to target interneurons<i>in vitro</i>and<i>in vivo</i> (2016)

LV-CCK-NpHR2.0-EYFP may be useful for targeting CCK+ interneurons in culture. GAD67/CCK-driven lentiviral constructs are expressed in vivo, although expression is not specific for interneurons. Overall, expression levels are low compared to opsins driven by pyramidal cell promoters. A better understanding of GAD67 and CCK promoter structure or alternative techniques is required to reliably target opsins to interneurons using viral vectors.
Molecular Forms of Prostate-specific Antigen in Malignant and Benign Prostatic Tissue: Biochemical and Diagnostic Implications (2000)

The amounts of tPSA and the PSA isoforms in prostatic tissue explain neither the concentrations of tPSA and PSA isoforms in serum nor the behavior of the ratio fPSA/tPSA in patients with BPH and PCa.
Sequential Correlated Level Shifting: A Switched-Capacitor Approach for High-Accuracy Systems (2013)

Analog circuit accuracy is severely limited by finite and nonlinear opamp gain. For switched-capacitor circuits, correlated level shifting (CLS) is an effective technique to improve system accuracy with negligible additive noise. A modification of this method, called sequential CLS, is introduced in this brief, which provides dramatic increases in the effective accuracy of a switched-capacitor structure. Measurements of prototype sample-and-hold structures utilizing simple single-stage opamps in an LP 90-nm CMOS technology show that at the same power and area consumption, the proposed modification can improve the settling accuracy of simple CLS from 5.8 to 8.8 bits with two additional sequential steps.
Importance of Electron Transport Ability in Naphthalene Diimide-Based Polymer Acceptors for High-Performance, Additive-Free, All-Polymer Solar Cells (2015)

We report a systematic investigation of the correlations between the electron mobility of polymer acceptors and the photovoltaic performances of all-polymer solar cells (all-PSCs) by using a series of naphthalene diimide (NDI)-based polymer acceptors. Polymer acceptors typically have much lower electron mobility than fullerenes, which is one of the main factors in limiting the performance of all-PSCs. In addition, the anisotropic charge transport properties of the polymers require careful control of their packing structure and orientation suitable for their use in all-PSCs. To control the planarity of the polymer backbone and enhance electron mobility, we introduce three different electron-rich units (i.e., thiophene (T), bithiophene (T2), and thienylene–vinylene–thienylene (TVT)) into the NDI-based polymers. Particularly, P(NDI2OD–TVT) polymers exhibit the highest electron mobility (2.31 cm2 V–1 s–1) in organic field-effect transistors owing to various factors including enhanced degree of coplanarity, strong intermolecular interactions, and facilitated three-dimensional (3-D) charge transport. In addition, the superb electron transport capability of P(NDI2OD–TVT) leads to a well-balanced hole/electron mobility ratio in all-PSC blends. Thus, all-PSCs based on the P(NDI2OD–TVT) acceptor exhibit a high power conversion efficiency of 4.25% without any solvent additives or thermal treatments. We suggest that the high electron transport ability of the polymer acceptor is important requirement for producing high-performance, additive-free all-PSCs.
EAN consensus review on prevention, diagnosis and management of tick‐borne encephalitis (2017)

Tick-borne encephalitis is a viral CNS infection that may result in long-term neurological sequelae. Since its incidence in Europe is increasing due to broadening of endemic areas and prolongation of the tick activity season, the health burden of TBE is enlarging. There is no effective antiviral treatment for TBE, but the disease may be effectively prevented by vaccination.
Hedgehog signaling is required for cranial neural crest morphogenesis and chondrogenesis at the midline in the zebrafish skull (2005)

Neural crest cells that form the vertebrate head skeleton migrate and interact with surrounding tissues to shape the skull, and defects in these processes underlie many human craniofacial syndromes. Signals at the midline play a crucial role in the development of the anterior neurocranium, which forms the ventral braincase and palate, and here we explore the role of Hedgehog (Hh) signaling in this process. Using sox10:egfp transgenics to follow neural crest cell movements in the living embryo, and vital dye labeling to generate a fate map, we show that distinct populations of neural crest form the two main cartilage elements of the larval anterior neurocranium: the paired trabeculae and the midline ethmoid. By analyzing zebrafish mutants that disrupt sonic hedgehog (shh) expression, we demonstrate that shh is required to specify the movements of progenitors of these elements at the midline, and to induce them to form cartilage. Treatments with cyclopamine, to block Hh signaling at different stages, suggest that although requirements in morphogenesis occur during neural crest migration beneath the brain, requirements in chondrogenesis occur later, as cells form separate trabecular and ethmoid condensations. Cell transplantations indicate that these also reflect different sources of Shh, one from the ventral neural tube that controls trabecular morphogenesis and one from the oral ectoderm that promotes chondrogenesis. Our results suggest a novel role for Shh in the movements of neural crest cells at the midline, as well as in their differentiation into cartilage, and help to explain why both skeletal fusions and palatal clefting are associated with the loss of Hh signaling in holoprosencephalic humans.
Effect of Finerenone on Chronic Kidney Disease Outcomes in Type 2 Diabetes (2020)

In patients with CKD and type 2 diabetes, treatment with finerenone resulted in lower risks of CKD progression and cardiovascular events than placebo. (Funded by Bayer; FIDELIO-DKD ClinicalTrials.gov number, NCT02540993.).
Anglo-Norman Relations with Connacht, 1169-1224 (1938)

Historians generally have accepted the view that the Irish kingdom of Connacht maintained an independent political existence until the death of Cathal Crovderg (1224). From the time of Henry II, however, individual Anglo-Norman adventurers cast envious glances at the broad lands ruled over by the house of O'Connor, and on more than one occasion in this period it seemed as if the foreigner would secure complete control of the province. An attempt will here be made to describe the successive endeavours to wrest their kingly power from the O'Connors before the death of Crovderg, and the circumstances which brought these to nothing.
Techno-economic comparison of hot water and dilute acid pretreatment for biochemical production of ethanol from corn stover and evaluation of alternative scenarios to purchasing cellulase enzymes (2009)

Techno-economic analysis was conducted to compare hot water pretreatment and dilute acid pretreatment for biochemical production of ethanol from corn stover, and to compare several enzyme production schemes as alternatives to on-site enzyme production. Each of these scenarios was modeled in detail and economic analysis was performed to estimate the total capital investment (TCI) and Minimum Ethanol Selling Price (MESP), and Equivalent Purchased Enzyme Price for the enzyme production scenarios. In Chapter 2 hot water and dilute acid pretreatment technologies are compared for both an n plant design as well as a pioneer plant. Plants are modeled assuming they receive 2000 MT/day (metric tonne per day) of biomass. The dilute acid pretreatment process has the lowest MESP, which is estimated to be $3.40/gal EtOH, compared to $4.29/gal EtOH for the hot water pretreatment scenario. Sensitivity analysis shows that the MESP for the dilute acid pretreatment scenario is most sensitive to feedstock costs, enzyme loading, enzyme cost, and installed equipment costs. The MESP ranges from $3.37 to $3.93 under the assumed ranges for sensitivity parameters. Cellulosic ethanol production has yet to be commercialized and a pioneer plant is expected to be significantly more expensive than an n plant. To assess the impact of technological maturity on pioneer plant capital cost and plant performance a cost growth analysis was performed using a method developed by the RAND Corporation. Pioneer plant costs are estimated for three scenarios: optimistic, most probable and pessimistic. The estimated range of MESPs for the pioneer plant were substantially larger than for the n plant. The MESPs for the model with dilute acid pretreatment were $4.19, $5.22 and $6.68/Gal EtOH for the optimistic, most probable and pessimistic scenarios, respectively. The Total Capital Investment (TCI) for the three respective scenarios increased by 53%, 104%, and 183% above the n plant TCI. Enzymes are one of the most significant costs of cellulosic ethanol production. Chapter 3 analyzes two enzyme production schemes as alternatives to purchasing enzymes. The first is the production of enzymes on-site for a stand-alone plant. The competitiveness of on-site enzyme production with purchasing enzymes is compared among plant scales varying from 500 MT/day to 3000 MT/day. The second scheme is the production of both ethanol and excess enzymes at a central plant for export to satellite plants producing only ethanol. Two cases were examined for this scheme—one in which the central plant supplies enzymes to two satellite plants and another with four satellite plants. Both the central plant and satellite plants in this scheme receive 2000 MT/day of corn stover.
A First Synthesis of Thiophene Dendrimers (2002)

[structure: see text] Thiophene dendrons and dendrimers were designed and synthesized using a convergent approach. Metal-mediated coupling reactions were used in the synthesis. A rational approach allowed the formation of alphaalpha, betabeta, and alphabeta linkages between the dendrons and thiophene units.
Face completion with pyramid semantic attention and latent codes (2020)

Face completion, which is to reproduce the missing region of an incomplete face image, has achieved promising performance due to the adoption of generative adversarial network (GANs) and the development of GPU. However, current network frameworks always ignore that face images usually have strong semantic correlation and symmetry, failing to recover some semantically plausible details especially for filling in large contiguous holes. To produce visually realistic and semantically correct results, we propose a two-stage adversarial framework, the first stage is to produce coarse images and works as a prior for searching the most similar latent codes in reference sets, which are combined by composing their intermediate feature maps. Besides, the second stage captures texture information with our novel pyramid semantic attention block for fully using semantic information and embed the learned structure features into the inpainting process. Our attention layer considers not only the known contents but also our reconstructed parts, so that we can improve the realism of reconstructing parts, then apply this attention layer into a novel pyramid structure. In addition, we add weights in the loss function around the predicted boundary for encouraging our model to generate clearer contour lines and better interpolation properties. Empirically, the experiment on CelebA dataset shows our proposed method is effective to fill in large contiguous holes on the face images. Especially, the SSIM score of our model is nearly higher 0.1 than context encoder model.
On learning control in industrial furnaces and boilers (2002)

Presents some contributions to the integrated learning control and supervision of industrial thermal systems such as furnaces and boilers. Three application case-studies have enabled us to demonstrate practical feasibility and efficiency of the learning control and supervision approach in thermal systems automation. This approach provides for a methodology for solving the problem of process identification, control and supervision for complex, multi-variable, thermal plants within a time-domain setting and by using recorded, operating time series and/or rough, non-parametric process models.
Two distinct pools of recirculating T lymphocytes: migratory characteristics of nodal and intestinal T lymphocytes. (1977)

A pronounced asymmetry in the recirculation from blood to lymph of resting small recirculating T lymphocytes is described. When 51Cr-labeled small T-recirculating lymphocytes (TRL) from intestinal lymph were infused intravenously their relative recovery in intestinal lymph was about twice that in nodal lymph. In contrast, the relative recovery in nodal lymph of 51Cr-labeled nodal TRL was twice that in intestinal lymph. Intestinal TRL migrated in large numbers through the small intestine. Nodal TRL did not. It is proposed that the pool of recirculating small T lymphocytes consists of two major subdivisions, an intestinal pool and a nodal pool. The nodal circulation comprises small TRL which traverse PCV in all lymph nodes (LN) but not the small intestine. The intestinal circulation comprises small TRL which do not traverse PCV in LN, but which do recirculate through the small intestine from which they pass via afferent lymphatics to the mesenteric LN and subsequently via the thoracic duct into the blood. It is suggested that the intestinal circulation is present in the fetus and that its initial development is independent of extrinsic antigen.
Armed and disarmed n-pentenyl glycosides in saccharide couplings leading to oligosaccharides (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTArmed and disarmed n-pentenyl glycosides in saccharide couplings leading to oligosaccharidesD. R. Mootoo, Peter. Konradsson, Uko. Udodong, and Bert. Fraser-ReidCite this: J. Am. Chem. Soc. 1988, 110, 16, 5583–5584Publication Date (Print):August 1, 1988Publication History Published online1 May 2002Published inissue 1 August 1988https://doi.org/10.1021/ja00224a060Request reuse permissionsArticle Views3014Altmetric-Citations515LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (265 KB) Get e-Alertsclose Get e-Alerts
Optical Recording of Action Potentials with Second-Harmonic Generation Microscopy (2004)

Nonlinear microscopy has proven to be essential for neuroscience investigations of thick tissue preparations. However, the optical recording of fast (approximately 1 msec) cellular electrical activity has never until now been successfully combined with this imaging modality. Through the use of second-harmonic generation microscopy of primary Aplysia neurons in culture labeled with 4-[4-(dihexylamino)phenyl][ethynyl]-1-(4-sulfobutyl)pyridinium (inner salt), we optically recorded action potentials with 0.833 msec temporal and 0.6 microm spatial resolution on soma and neurite membranes. Second-harmonic generation response as a function of change in membrane potential was found to be linear with a signal change of approximately 6%/100 mV. The signal-to-noise ratio was approximately 1 for single-trace action potential recordings but was readily increased to approximately 6-7 with temporal averaging of approximately 50 scans. Photodamage was determined to be negligible by observing action potential characteristics, cellular resting potential, and gross cellular morphology during and after laser illumination. High-resolution (micrometer scale) optical recording of membrane potential activity by previous techniques has been limited to imaging depths an order of magnitude less than nonlinear methods. Because second-harmonic generation is capable of imaging up to approximately 400 microm deep into intact tissue with submicron resolution and little out-of-focus photodamage or bleaching, its ability to record fast electrical activity should prove valuable to future electrophysiology studies.
Hardware implementation of a novel, reduced rating active filter for 3-phase, 4-wire loads (2002)

This paper presents the hardware results of a new active filter topology with reduced VA rating for 3-phase, 4-wire loads. The scheme consists of a single-phase inverter connected between the zig-zag transformer neutral and the utility neutral in addition to a three-phase inverter connected to the delta winding of the zig-zag transformer. Compared to other reported schemes, the inverter VA rating in this scheme is reduced by a factor of six. This reduction in the inverter VA rating is mainly due to the zero-sequence current inverter having a low VA rating. The equations for this active filter are derived. The simulation results are verified by means of experimental results from a proof-of-concept prototype.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Biochemical and immunological characterization of human opsonic alpha2SB glycoprotein: its identity with cold-insoluble globulin. (1978)

The relationship between human cold-insoluble globulin (CIg, plasma fibronectin) and the human serum opsonic alpha2SB glycoprotein was investigated using immunochemical and biochemical techniques. The two proteins appeared to have identical molecular weights by sodium dodecyl sulfate-polyacrylamide gel electrophoresis on 3.3% gels; have identical migration in the native state on 2.7 to 27% gradient polyacrylamide gels; and have a similar amino acid composition within the accuracy of analysis. Human serum demonstrates antigenic identity when diffused against monospecific antisera to both proteins confirming the presence of common antigenic sites on both molecules. Purified human serum opsonic alpha2SB glycoprotein and purified CIg also demonstrate antigenic identity when diffused against monospecific antiserum to either of the isolated proteins. Antiserum to both proteins also inhibits in vitro hepatic Kupffer cell phagocytic uptake of test particles. These results suggest the idenity of these two proteins and reveal a major physiological function for human plasma CIg. Thus, CIg may be important in the regulation of hepatic reticuloendothelial phagocytic activity and nonspecific systemic host defense. This process of systemic host defense has been shown to be depressed in patients following trauma, major surgery, burn injury, and during neoplastic disease, and, in part, mediated by a deficiency or depletion of the alpha2SB glycoprotein.
ARZombie: A Mobile Augmented Reality Game with Multimodal Interaction (2015)

Augmented reality games have the power to extend virtual gaming into real world scenarios with real people, while enhancing the senses of the user. This paper describes the AR- Zombie game developed with the aim of studying and developing mobile augmented reality applications, specifically for table
Underdiagnosis of Genital Herpes by Current Clinical and Viral-Isolation Procedures (1992)

The current strategy for diagnosing genital HSV infection in women misses many cases. Newly developed type-specific serologic methods can identify women with recurrent genital HSV-2 infection, as well as those with unrecognized or subclinical infection.
Het Christen Democratische Affiche (2015)

Als gevolg van de invoering van het algemeen kiesrecht in 1917, weliswaar toen enkel geldend voor mannen vanaf 25 jaar, en de afschaffing van het districtenstelsel, veranderde het karakter van de Tweede Kamerverkiezingen ingrijpend: voortaan telde elke stem. Om alle kiezers te mobiliseren gingen politieke partijen zich beter organiseren en nieuwe vormen van propaganda ontwikkelen. Vanaf de verkiezingen van 1918 is daarom bij veel partijen een massamedium bij uitstek te zien: het verkiezingsaffiche. In het boek beschrijven de auteurs de ontwikkeling van de landelijke verkiezingsaffiches van het CDA en zijn voorgangers, van 1918 tot en met 2012. Een rode draad in het boek is de samenwerking tussen de drie confessionele partijen ARP, CHU en KVP, die later opgingen in het CDA.
Minimally invasive thoracic surgery. (2000)

To reduce the risk, trauma, and expense of intrathoracic surgical treatments, minimally invasive procedures performed with the assistance of fiberoptic video technology have been developed for thoracic and bronchial surgeries. The surgical treatment of nearly every intrathoracic condition can benefit from a video-assisted approach performed through a few small incisions. Video-assisted thoracoscopic and rigid-bronchoscopic surgery have improved the results of thoracic procedures by decreasing postoperative pain and speeding the return to normal activity. From January 1992 to February 2000, 185 patients underwent 189 video-assisted thoracoscopic procedures in Ochsner Foundation Hospital for various conditions with good results; only 18 procedures (9.5%) required conversion to open thoracotomy. Video-assisted rigid bronchoscopic surgery has been helpful in managing tracheobronchial conditions and complications following lung transplantation. Ninety-nine patients with bronchial complications following lung transplantation and 20 patients with tracheobronchial conditions not related to transplantation have undergone therapeutic techniques involving video-assisted rigid bronchoscopy.
Self-assembled monolayer cleaning methods: Towards fabrication of clean high-temperature superconductor nanostructures (2005)

Although extensive amounts of research have been carried out on superconductor-normal metal-superconductor (SNS) electronic devices, the fabrication of superconductor SNS devices still remains difficult. Surface modification of high-temperature superconductors could be a way to control the interface of SNS electronic device fabrication. Here, we developed a cleaning method for thin films of high-temperature superconductor surface based on self-assembled monolayers. High-quality c-axis orientated YBa2Cu3O7−δ (i.e., YBCO) and Y0.6Ca0.4Ba1.6La0.4Cu3O7−δ (i.e., TX-YBCO) thin films were deposited by standard laser ablation methods. YBCO/Au/YBCO and TX-YBCO/Au/TX-YBCO planar type junctions were fabricated by photolithography, focused-ion-beam milling, and ex situ sputter depositions. A 40–50nm nanotrench was ion milled on the thin film by FIB, and a thin gold layer was deposited by an ex situ method on the nanotrench to connect the two separated high-temperature superconductor electrodes. SEM, AFM, and R vs T resistivity measurements were used to compare the corrosion layer formed in the interface of the SNS junctions with the SAM cleaned SNS junction. Evidence here suggests that the SAM cleaning method can be used to remove the degradation layer on the surface of cuprate superconductors. The obtained contact resistivity value, (10−8Ωcm2) for a SNS junction with SAM treatment is comparable with that of SNS junctions fabricated by the in situ methods.