gebhart/patrepeval huggingface dataset:
Rational design of carbon network cross-linked Si–SiC hollow nanosphere as anode of lithium-ion batteries (2013)

This study aims to realize controllable synthesis of Si-based nanostructures from common and easily accessible silica nanoparticles and to study their component/structure-dependent electrochemical performance as an anode of lithium-ion batteries (LIBs). To this end, a controllable route based on deliberate design has been developed to prepare hollow Si-based nanospheres with tunable composition and crystal structure at the nanoscale. The synthesis process started with coating silica nanoparticles with a carbonaceous polymer with a controllable thickness followed by magnesiothermic reduction. An Si-SiC-C composite was finally produced with a unique hollow sphere structure featuring Si-SiC nanoparticles encapsulated by a cross-linked carbon film network. In addition to the scalability of the synthetic route, the resulting composite exhibits a number of advantageous properties, including excellent electrical conductivity, highly accessible surfaces, structural coherence, and a favorable structure for the formation of a stable solid-electrolyte interphase, which makes it attractive and promising for advanced anode materials of LIBs.
Empagliflozin (BI 10773), a Potent and Selective SGLT2 Inhibitor, Induces Dose‐Dependent Glucosuria in Healthy Subjects (2013)

Empagliflozin is an orally available, selective inhibitor of sodium glucose cotransporter 2. In this study, single oral doses of empagliflozin from 0.5 to 800 mg were not associated with any clinically significant safety concerns in healthy male volunteers. The incidence of adverse events (AEs) was similar in subjects receiving placebo (22.2%) or empagliflozin (25.0%) in the single rising dose part of the study and after 50 mg empagliflozin under fed (28.6%) or fasted (28.6%) conditions. The most frequent AE was headache. No clinically relevant changes in laboratory or electrocardiogram (ECG) measurements were observed. Single oral doses of empagliflozin were rapidly absorbed, reaching peak levels after 1.0-2.1 hours. Increases in empagliflozin exposure were roughly dose-proportional and a dose-dependent increase in urinary glucose excretion was observed for empagliflozin doses up to 100 mg. After ingestion of 50 mg empagliflozin in conjunction with a high-fat, high-calorie meal, no clinically relevant changes in exposure were found, indicating that empagliflozin can be administered independent of food. Empagliflozin up to 800 mg did not generate clinically significant safety concerns in healthy male subjects. The pharmacokinetic properties of empagliflozin support once daily administration independent of food.
Semantic Similarity Measures in the Biomedical Domain by Leveraging a Web Search Engine (2013)

Various researches in web related semantic similarity measures have been deployed. However, measuring semantic similarity between two terms remains a challenging task. The traditional ontology-based methodologies have a limitation that both concepts must be resided in the same ontology tree(s). Unfortunately, in practice, the assumption is not always applicable. On the other hand, if the corpus is sufficiently adequate, the corpus-based methodologies can overcome the limitation. Now, the web is a continuous and enormous growth corpus. Therefore, a method of estimating semantic similarity is proposed via exploiting the page counts of two biomedical concepts returned by Google AJAX web search engine. The features are extracted as the co-occurrence patterns of two given terms P and Q, by querying P, Q, as well as P AND Q, and the web search hit counts of the defined lexico-syntactic patterns. These similarity scores of different patterns are evaluated, by adapting support vector machines for classification, to leverage the robustness of semantic similarity measures. Experimental results validating against two datasets: dataset 1 provided by A. Hliaoutakis; dataset 2 provided by T. Pedersen, are presented and discussed. In dataset 1, the proposed approach achieves the best correlation coefficient (0.802) under SNOMED-CT. In dataset 2, the proposed method obtains the best correlation coefficient (SNOMED-CT: 0.705; MeSH: 0.723) with physician scores comparing with measures of other methods. However, the correlation coefficients (SNOMED-CT: 0.496; MeSH: 0.539) with coder scores received opposite outcomes. In conclusion, the semantic similarity findings of the proposed method are close to those of physicians' ratings. Furthermore, the study provides a cornerstone investigation for extracting fully relevant information from digitizing, free-text medical records in the National Taiwan University Hospital database.
[The effect of 5-days of cetirizine, desloratadine, fexofenadine 120 and 180 mg, levocetirizine, loratadine treatment on the histamine-induced skin reaction and skin blood flow--a randomized, double-blind, placebo controlled trial]. (2006)

Following the end of the treatment, the effect of the antihistamines on skin reaction was subsiding in such an order: after 24 hours in case of loratadine and desloratadine, after two days for both doses of fexofenadine, and 3-4 days for cetirizine and levocetirizine.
Towards a psychology of collective memory (2008)

This article discusses the place of psychology within the now voluminous social scientific literature on collective memory. Many social scientists locate collective memories in the social resources that shape them. For scholars adopting this perspective, collective memories are viewed as transcending individuals; that is, as being "in the world". Others recognise that, in the final analysis, individuals must remember collective as well as individual memories. These scholars treat collective memories as shared individual memories. We attempt to bridge these two approaches by distinguishing between the design of social resources and memory practices, on one hand, and on the other, the effectiveness of each in forming and transforming the memories held by individuals and the psychological mechanisms that guide this effectiveness.
Cutaneous Toxic Effects Associated With Vemurafenib and Inhibition of the BRAF Pathway (2012)

The development of sorafenib-like cutaneous sequelae (squamous cell carcinomas, keratosis pilaris-like eruptions, seborrheic dermatitis-like rashes, and hand-foot skin reaction) associated with vemurafenib administration suggests that BRAF inhibition alone may be sufficient to induce these changes.
Copolymerization. VII.<sup>1</sup> Copolymerizations of Some Further Monomer Pairs (1948)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCopolymerization. VII.1 Copolymerizations of Some Further Monomer PairsFrederick M. Lewis, Cheves Walling, William Cummings, Emorene R. Briggs, and W. J. WenischCite this: J. Am. Chem. Soc. 1948, 70, 4, 1527–1529Publication Date (Print):April 1, 1948Publication History Published online1 May 2002Published inissue 1 April 1948https://pubs.acs.org/doi/10.1021/ja01184a069https://doi.org/10.1021/ja01184a069research-articleACS PublicationsRequest reuse permissionsArticle Views239Altmetric-Citations84LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Treatment with 5-HT potentiates development of pulmonary hypertension in chronically hypoxic rats (1997)

The aim of this study was to investigate the potential role of 5-hydroxytryptamine (5-HT) on development of pulmonary hypertension during chronic exposure to mild (15% O2) and severe (10% O2) hypoxia. In isolated lungs from normoxic rats preconstricted with U-46619, 5-HT (10(-12)-10(-8) M) induced dose-dependent vasodilation (n = 6), which was suppressed by the NO synthesis inhibitor nitro-L-arginine methyl ester (L-NAME, 10(-4) M, n = 5) and reduced by the 5-HT3-receptor antagonist MDL-7222 (10(-5) M, n = 6). The vasoconstriction that was observed with higher concentrations of 5-HT (10(-7)-10(-4) M) was inhibited by ketanserin (10(-5) M) and methiothepin (10(-5) M, n = 6 each). The vasodilator response to 5-HT was suppressed in lungs from rats exposed to 10% O2 but not 15% O2 (n = 6 each). In conscious rats, intravenous administration of 5-HT potentiated the pulmonary pressor response to acute hypoxia (10% O2, n = 5), an effect that remained unchanged after pretreatment with a 5-HT1 and a 5-HT2 antagonist (n = 4) but was attenuated after treatment with the cyclooxygenase inhibitor meclofenamate (n = 4). Treatment with 5-HT (5 nmol/h i.v. by osmotic pumps) for 2 wk in rats simultaneously exposed to 10% O2 increased pulmonary arterial pressure, right ventricular hypertrophy, and muscularization of pulmonary vessels in comparison with their hypoxic controls (n = 12 each). No changes occurred in 15% O2 hypoxic rats (n = 12 each). The present findings show that 5-HT potentiates development of pulmonary hypertension in rats exposed to chronic hypoxia.
The Maudsley long-term follow-up of child and adolescent depression (2002)

The high and enduring long-term costs associated with childhood depression and conduct disorder give further reason for early and effective intervention.
Traditional and emerging materials for optical metasurfaces (2016)

Abstract One of the most promising and vibrant research areas in nanotechnology has been the field of metasurfaces. These are two dimensional representations of metaatoms, or artificial interfaces designed to possess specialized electromagnetic properties which do not occur in nature, for specific applications. In this article, we present a brief review of metasurfaces from a materials perspective, and examine how the choice of different materials impact functionalities ranging from operating bandwidth to efficiencies. We place particular emphasis on emerging and non‐traditional materials for metasurfaces such as high index dielectrics, topological insulators and digital metamaterials, and the potentially transformative role they could play in shaping further advances in the field.
Hierarchical Zeolite Beta via Nanoparticle Assembly with a Cationic Polymer (2011)

Nanozeolite aggregates with secondary pores of tunable sizes were prepared by the flocculating action of a cationic polymer. Specifically, highly concentrated zeolite beta precursor gels were hydrothermally converted in the presence of the cationic polymer polydiallyldimethylammonium chloride (PDDA). Without polymer, highly crystalline zeolite beta in the form of nanosized particles was obtained from colloidal solutions at high yield. Upon addition of polymer, these nanoparticles were flocculated into self-sustaining, easily retrievable mesoporous aggregates in a one-step procedure at nearly 100% yield, showing interparticle pores with very high mesopore volumes and surface areas. The influence of the amount of polymer, its molecular weight as well as the nature of the silica precursor on pore characteristics, crystallinity, and morphology were studied with nitrogen sorption, mercury intrusion porosimetry and electron microscopy, respectively. Changing the polymer concentration is a powerful parameter to effectively tune the interstitial pore size between 40 and 400 nm by controlling the growth of the zeolite beta particles.
Crosstalk between Insulin/Insulin-like Growth Factor-1 Receptors and G Protein-Coupled Receptor Signaling Systems: A Novel Target for the Antidiabetic Drug Metformin in Pancreatic Cancer (2010)

Insulin/insulin-like growth factor 1(IGF-1) receptors and G protein-coupled receptors (GPCR) signaling systems are implicated in autocrine-paracrine stimulation of a variety of malignancies, including ductal adenocarcinoma of the pancreas, one of the most lethal human diseases. Novel targets for pancreatic cancer therapy are urgently needed. We identified a crosstalk between insulin/IGF-1 receptors and GPCR signaling systems in pancreatic cancer cells, leading to enhanced signaling, DNA synthesis, and proliferation. Crosstalk between these signaling systems depends on mammalian target of rapamycin (mTOR) complex 1 (mTORC1). Metformin, the most widely used drug in the treatment of type 2 diabetes, activates AMP kinase (AMPK), which negatively regulates mTORC1. Recent results show that metformin-induced activation of AMPK disrupts crosstalk between insulin/IGF-1 receptor and GPCR signaling in pancreatic cancer cells and inhibits the growth of these cells in xenograft models. Given that insulin/IGF-1 and GPCRs are implicated in other malignancies, a similar crosstalk mechanism may be operative in other cancer cell types. Recent epidemiological studies linked administration of metformin with a reduced risk of pancreatic, breast, and prostate cancer in diabetic patients. We posit that crosstalk between insulin/IGF-1 receptor and GPCR signaling is a mechanism for promoting the development of certain types of cancer and a target for the prevention and therapy of these diseases via metformin administration.
Organometallic Chemistry: An Overview (1988)

Organometallic Chemistry: Development of a Discipline The Metal-Carbon Bond: Methods of Synthesis Ionic Metal-Carbon Bonds ''Electron-Deficient'' Metal-Carbon Bonds Metal-Carbon Sigma Bonds. I: The Reactive Metals Metal-Carbon Sigma Bonds. II: The Heavy Metals Metal-Carbon Sigma Bonds. III: The Metalloids Metal-Carbon Synergistic Bonds. I: Mononuclear Complexes of Divalent Carbon Metal-Carbon Synergistic Bonds. II: Mononuclear Complexes on Unsaturated Hydrocarbons Metal-Carbon Synergistic Bonds. III: Polynuclear Complexes Organometallic Compounds in Biology. I: Medicinal and Biochemical Uses Organometallic Compounds in Biology. II: Toxicology and Biocidal Uses Organometallic Compounds in Biology. III: Environmental Occurrence.
A comprehensive kinetic model for high‐temperature free radical production of styrene/methacrylate/acrylate resins (2010)

Abstract n ‐Butyl methacrylate/styrene/ n ‐butyl acrylate (BMA/ST/BA) high‐temperature starved‐feed solution semibatch copolymerization and terpolymerization experiments with varying monomer feed composition, final polymer content, monomer feed time, and reaction temperature were carried out. A comprehensive mechanistic terpolymerization model implemented in PREDICI includes methacrylate depropagation, acrylate backbiting, chain scission, and macromonomer propagation, as well as penultimate chain‐growth and termination kinetics. The generality of the model was verified by comparison with terpolymerization data sets from two laboratories that demonstrate the impact of high‐temperature secondary reactions on polymerization rate and polymer molecular weight. © 2010 American Institute of Chemical Engineers AIChE J, 2011
Experimental and DFT Computational Study of β-Me and β-H Elimination Coupled with Proton Transfer: From Amides to Enamides in Cp*<sub>2</sub>MX (M = La, Ce) (2016)

International audience
Insomnia: Psychological Assessment and Management (1993)

Originally published in Contemporary Psychology: APA Review of Books, 1996, Vol 41(6), 621. Insomnia affects from 20 to 40 percent of all adults, particularly women and the elderly, yet there is widespread belief that chronic insomnia is not really a medical problem and that it can be treated only w
Synergistic Effect between Fucoidan and Antibiotics against Clinic Methicillin-Resistant &lt;i&gt;Staphylococcus aureus&lt;/i&gt; (2015)

Fucoidan is a sulfated polysaccharide that is primarily extracted from brown seaweeds which has been broadly studied in recent years due to its numerous biological properties, including anticoagulant, antithrombotic, antitumor, and antiviral activities. In this study, fucoidan was evaluated against clinic isolated methicillin-resistant Staphylococcus aureus (MRSA) 1 - 20, either alone or with antibiotics, via broth dilution method and checkerboard and time kill assay. Minimum inhibitory concentrations (MICs)/Minimum bactericidal concentrations (MBCs) values for the fucoidan against all the tested bacteria ranged between 64 - 512/256 - 2048 microg/mL, for ampicillin 32 - 1024/64 - 1024 microg/mL and for oxacillin 8 - 64/16 - 256 microg/mL respectively. Furthermore, the MIC and MBC were reduced to one half-eighth as a result of the combination of the fucoidan with antibiotics. 2 - 6 hours of treatment with 1/2 MIC of fucoidan with 1/2 MIC of antibiotics resulted from an increase of the rate of killing in units of CFU/mL to a greater degree than was observed with alone. These results suggest that fucoidan could be employed as a natural antibacterial agent against multi-drug bacteria.
Identification of Species in Animal Feedstuffs by Polymerase Chain Reaction−Restriction Fragment Length Polymorphism Analysis of Mitochondrial DNA (2001)

Restriction site analysis of Polymerase Chain Reaction (PCR) products of cytochrome b mitochondrial DNA was applied to identify species in meat meal and animal feedstuffs. PCR was used to amplify a variable region of cytochrome b mitochondrial DNA gene. Species differentiation was determined by digestion of the obtained 359 bp amplicon with restriction enzymes, which generated species-specific electrophoresis patterns; the sequencing of PCR products was used as confirming analysis. PCR-RFLP analysis revealed the presence of meat meal in animal feedstuffs and distinguished species of interest. The results supported the application of the method in control measures which should be adopted for meat-meal-based animal feed, as suggested by EU law. As a technical improvement, to simplify the analysis, the number of enzymes presented in this study for the detection of different species was smaller than others described in the literature; discrimination between ruminant and nonruminant species and between mammalian and poultry species was possible with few digestions.
Molecular MRI in the Earth’s Magnetic Field Using Continuous Hyperpolarization of a Biomolecule in Water (2016)

In this work, we illustrate a method to continuously hyperpolarize a biomolecule, nicotinamide, in water using parahydrogen and signal amplification by reversible exchange (SABRE). Building on the preparation procedure described recently by Truong et al. [ J. Phys. Chem. B , 2014 , 118 , 13882 - 13889 ], aqueous solutions of nicotinamide and an Ir-IMes catalyst were prepared for low-field NMR and MRI. The (1)H-polarization was continuously renewed and monitored by NMR experiments at 5.9 mT for more than 1000 s. The polarization achieved corresponds to that induced by a 46 T magnet (P = 1.6 × 10(-4)) or an enhancement of 10(4). The polarization persisted, although reduced, if cell culture medium (DPBS with Ca(2+) and Mg(2+)) or human cells (HL-60) were added, but was no longer observable after the addition of human blood. Using a portable MRI unit, fast (1)H-MRI was enabled by cycling the magnetic field between 5 mT and the Earth's field for hyperpolarization and imaging, respectively. A model describing the underlying spin physics was developed that revealed a polarization pattern depending on both contact time and magnetic field. Furthermore, the model predicts an opposite phase of the dihydrogen and substrate signal after one exchange, which is likely to result in the cancelation of some signal at low field.
Astrometry.net: Automatic Recognition and Calibration of Astronomical Images (2010)

We present Astrometry.net, a system for automatically recognizing and astrometrically calibrating astronomical images, using the information in the image pixels alone. The system is based on the geometric hashing approach in computer vision: We use the geometric relationships between low-level features (stars and galaxies), which are relatively indistinctive, to create geometric features that are distinctive enough that we can recognize images that cover less than one-millionth of the area of the sky. The geometric features are used to generate rapidly hypotheses about the location---the pointing, scale, and rotation---of an image on the sky. Each hypothesis is then evaluated in a Bayesian decision theory framework in order to ensure that most correct hypotheses are accepted while false hypotheses are almost never accepted. The feature-matching process is accelerated by using a new fast and space-efficient kd-tree implementation. The Astrometry.net system is available via a web interface, and the software is released under an open-source license. It is being used by hundreds of individual astronomers and several large-scale projects, so we have at least partially achieved our goal of helping ``to organize, annotate and make searchable all the world's astronomical information.''
Coagulation Efficiency and Residual Aluminum Content of Polyaluminum Silicate Chloride in Water Treatment (2004)

Abstract A series of polyaluminum silicate chlorides (PASC), which have different OH — /Al and Al/Si molar ratios, has been prepared by a copolymerization technique and a composite technique, after which the coagulation efficiency and the residual aluminum content of PASC for water treatment were compared with polyaluminum chloride (PAC) by jar test. The experimental results show that PASC has better coagulation efficiency and lower residual aluminum content than PAC, and the PASC prepared by the copolymerization technique gives a better coagulating effect than that prepared by the composite technique. In addition, the OH — /Al and Al/Si molar ratios have some effect on the coagulation effect and residual aluminum content of PASC in treated water. With increasing OH — /Al molar ratio and decreasing Al/Si molar ratio, the residual turbidity and residual aluminum content in treated water diminishes. The pH of the water sample also affects the residual aluminum content of the water and there is a lower residual aluminum content in the neutral pH range.
Simulation Study of an Injection Enhanced Insulated-Gate Bipolar Transistor With p-Base Schottky Contact (2016)

This paper proposes a new concept of Schottky contact insulated-gate bipolar transistor (SC-IGBT), which uses a top surface Schottky contact to the p-base as a hole barrier to enhance the conductivity modulation effect. TCAD simulation shows that the SC-IGBT offers a saturation voltage decrease of 19% or turn-OFF loss reduction of 46% when compared with a conventional field-stop IGBT. Furthermore, it potentially offers an alternative method of fabricating injection enhancement IGBTs, which is simpler than the existing buried n-type layer or narrow mesa trench structures.