gebhart/patrepeval huggingface dataset:
Effects of Inhibition of Angiotensin Converting Enzyme and Carbonic Anhydrase on Fluid Production by Ciliary Process, Choroid Plexus, and Pancreas (1989)

Inhibitors of angiotensin converting enzyme (ACE) (1) and of carbonic anhydrase (CA) (2,3) decrease intraocular pressure (IOP) in conscious rabbits. We asked whether ACE inhibition decreases IOP through effects on CA-dependent flow of aqueous humor (AH) and whether ACE inhibitors decrease other CA-dependent secretions. We show in anesthetized rabbits (a) that topical inhibitors of ACE decrease both IOP and AH flow as much as systemic inhibitors of CA; (b) that the maximal effects of ACE and CA inhibition are not additive, therefore these treatments may affect one or more components of a single system for fluid production; and that (c) ACE inhibitors do not work through inhibition of CA. Looking at other fluid production systems, we find (d) that cerebrospinal fluid (CSF) production is increased after ventriculocisternal perfusion with a potent ACE inhibitor and (e) that flow of pancreatic juice (PJ) is increased after systemic ACE inhibition.
A multimedia teleteaching system using an electronic whiteboard for two-way communication of motion videos and chalkboards (2002)

We present a multimedia teleteaching system that integrates an electronic whiteboard with our multimedia conferencing system which supports a motion video and a shared chalkboard. The teleteaching system uses personal computers that contain a motion video CODEC, and transmits data through the ISDN basic interface (128 kbps). An electronic whiteboard is attached to the personal computer for direct input by the teacher and display of that input. With this system, a teacher can use the electronic whiteboard as a real chalkboard. He can directly write test and draw figures in the area of the shared chalkboard by using the pen provided for the electronic whiteboard with a digitizer in it. When the teacher draws something on the shared chalkboard, it is automatically transmitted to the students' site and displayed on their shared chalkboard using the functions of multimedia conferencing system. The teacher's gestures and the contents of the whiteboard are captured by a video camera and transmitted to the students' computer. Conversely, a motion video of the students is transmitted from their site to the teacher's site.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Fault Diagnosis of Wind Turbine Gearbox Based on the Optimized LSTM Neural Network with Cosine Loss (2020)

The gearbox is one of the most fragile parts of a wind turbine (WT). Fault diagnosis of the WT gearbox is of great importance to reduce operation and maintenance (O&M) costs and improve cost-effectiveness. At present, intelligent fault diagnosis methods based on long short-term memory (LSTM) networks have been widely adopted. As the traditional softmax loss of an LSTM network usually lacks the power of discrimination, this paper proposes a fault diagnosis method for wind turbine gearboxes based on optimized LSTM neural networks with cosine loss (Cos-LSTM). The loss can be converted from Euclid space to angular space by cosine loss, thus eliminating the effect of signal strength and improve the diagnosis accuracy. The energy sequence features and the wavelet energy entropy of the vibration signals are used to evaluate the Cos-LSTM networks. The effectiveness of the proposed method is verified with the fault vibration data collected on a gearbox fault diagnosis experimental platform. In addition, the Cos-LSTM method is also compared with other classic fault diagnosis techniques. The results demonstrate that the Cos-LSTM has better performance for gearbox fault diagnosis.
Effect of early onset angiotensin converting enzyme inhibition on myocardial capillaries. (1992)

We investigated the preventive effects of long-term treatment with the angiotensin converting enzyme inhibitor ramipril on myocardial left ventricular hypertrophy and capillary length density in spontaneously hypertensive rats. Rats were treated in utero and subsequently up to 20 weeks of age with a high dose (1 mg/kg per day) or with a low dose (0.01 mg/kg per day) of ramipril. Animals given a high dose of ramipril remained normotensive, whereas those given a low dose developed hypertension in parallel to vehicle-treated controls. At the end of the treatment period, converting enzyme activity in heart tissue was inhibited dose-dependently in the treated groups. Both groups revealed an increase in myocardial capillary length density together with increased myocardial glycogen and reduced citric acid concentrations. Left ventricular mass was reduced only in high dose- but not in low dose-treated animals. Our results demonstrate that early onset treatment with a converting enzyme inhibitor can induce myocardial capillary proliferation, even at doses too low to antagonize the development of hypertension or left ventricular hypertrophy. We hypothesize that potentiation of kinins is responsible for this effect, probably by augmenting myocardial blood flow, which is a well-known trigger mechanism of angiogenesis in the heart.
A 240mhz Phase-locked-loop Circuit Implemented As A Standard Macro On Cmos Sog Gate Arrays (1992)

This paper describes a 240MHz Phase-Locked-Loop (PLL) macro implemented on a Sea-of-Gates (SOG) gate array. This implementation is unique because the macro can be placed anywhere on the array core. Multiple PLL macro utilization on one gate array chip is possible also. Applications for this PLL range from clock tree skew management to the synthesis of multiple frequencies from a single reference. This PLL macro has been implemented on a Siemens standard lum CMOS Sea-of-Gate array in the SCxD4 family.
Sorption properties of activated carbons obtained from corn cobs by chemical and physical activation (2012)

The paper presents results of a study on obtaining activated carbon from common corn cobs and on its use as adsorbent for removal of pollution from liquid and gas phases. The crushed precursor was subjected to pyrolysis at 500 and 800 °C in argon atmosphere and next to physical or chemical activation by CO2 and KOH respectively. The effect of pyrolysis conditions and activation method on the physicochemical properties of the materials obtained was tested. The sorption properties of the carbonaceous adsorbents obtained were characterized by determination of nitrogen dioxide and hydrogen sulphide sorption from gas stream in dry and wet conditions as well as by iodine and methylene blue removal from aqueous solution. The final products were microporous activated carbons of well-developed surface area varying from 337 to 1213 m2/g and showing diverse acid-base character of the surface. The results obtained in our study have proved that a suitable choice of the activation procedure for corn cobs permits production of cheap adsorbents with high sorption capacity toward toxic gases of acidic character as well as different pollutants from liquid phase.
Calcium-Dependent Protein Phosphorylation May Mediate the Gibberellic Acid Response in Barley Aleurone1 (1998)

Peptide substrates of well-defined protein kinases were microinjected into aleurone protoplasts of barley (Hordeum vulgare L. cv Himalaya) to inhibit, and therefore identify, protein kinase-regulated events in the transduction of the gibberellin (GA) and abscisic acid signals. Syntide-2, a substrate designed for Ca2+- and calmodulin (CaM)-dependent kinases, selectively inhibited the GA response, leaving constitutive and abscisic acid-regulated events unaffected. Microinjection of syntide did not affect the GA-induced increase in cytosolic [Ca2+], suggesting that it inhibited GA action downstream of the Ca2+ signal. When photoaffinity-labeled syntide-2 was electroporated into protoplasts and cross-linked to interacting proteins in situ, it selectively labeled proteins of approximately 30 and 55 kD. A 54-kD, soluble syntide-2 phosphorylating protein kinase was detected in aleurone cells. This kinase was activated by Ca2+ and was CaM independent, but was inhibited by the CaM antagonist N-(6-aminohexyl)-5-chloro-1-naphthalene-sulfonamide (250 mum), suggesting that it was a CaM-domain protein kinase-like activity. These results suggest that syntide-2 inhibits the GA response of the aleurone via an interaction with this kinase, implicating the 54-kD kinase as a Ca2+-dependent regulator of the GA response in these cells.
Synthesis of 3‐nitrophthalonitrile and tetra‐α‐substituted phthalocyanines (1995)

Abstract An efficient synthesis of phthalocyanines prepared from ortho ‐substituted phthalonitriles is described. The precursor to these phthalocyanines, 3‐nitrophthalonitrile, is a key reagent for syntheses of phthalonitriles substituted at the 3‐position by means of nucleophilic aromatic substitutions. An example of this type of phthalocyanine, prepared from 3‐(4‐cumylphenoxy)phthalonitrile, is compared with the phthalocyanine derived from 4‐(4‐cumylphenoxy)phthalonitrile. Substitution of the phthalocyanine at this more sterically crowded site causes a 20 nm bathochromic shift of the Q‐band (π‐π* transition).
Townsend discharge nitric oxide chemical ionization gas chromatography/mass spectrometry for hydrocarbon analysis of the middle distillates (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTownsend discharge nitric oxide chemical ionization gas chromatography/mass spectrometry for hydrocarbon analysis of the middle distillatesIsmet. Dzidic, H. A. Petersen, P. A. Wadsworth, and H. V. HartCite this: Anal. Chem. 1992, 64, 19, 2227–2232Publication Date (Print):October 1, 1992Publication History Published online1 May 2002Published inissue 1 October 1992https://pubs.acs.org/doi/10.1021/ac00043a008https://doi.org/10.1021/ac00043a008research-articleACS PublicationsRequest reuse permissionsArticle Views304Altmetric-Citations39LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Tissue-Type Plasminogen Activator Inhibitor ETIa from Erythrina variegata: Structural Basis for the Inhibitory Activity by Cloning, Expression, and Mutagenesis of the cDNA Encoding ETIa (1997)

Erythrina variegata trypsin inhibitor ETIa belongs to the Kunitz inhibitor family, but is unique in its ability to bind and inhibit tissue-type plasminogen activator (tPA). A cDNA clone encoding ETIa was isolated from the lambda gt11 cDNA library using specific antiserum as a probe and characterized by nucleotide sequencing. The cloned ETIa cDNA consists of 762 nucleotides and includes an open reading frame encoding a polypeptide of 198 amino acids. Comparison of the deduced protein sequence and the determined protein sequence indicated the presence of two signal peptides composed of 24 and 2 amino acids at the N- and C-termini, respectively. The cDNA encoding mature ETIa was amplified by polymerase chain reaction (PCR), ligated into the expression vector pET-22b, and expressed in Escherichia coli BL21(DE3). The recombinant ETIa (rETIa) was expressed in E. coli as inclusion bodies; it was purified to homogeneity by gel filtration on Sephadex G-75. The rETIa exhibited almost the same inhibitory activity toward trypsin and tPA as ETIa. Six mutants, in which the amino acids Arg61, Leu62, Arg63, and Ala65 were replaced by Pro, Phe, Leu/Asp, and Tyr, respectively, were constructed by site-specific mutagenesis and expressed in E. coli. The site-specific mutation of Arg63 to Leu (aR63L) or Asp (aR63D) in ETIa resulted in abolition of the inhibitory activities toward both trypsin and tPA. The mutants aR61P and aL62F showed significantly reduced tPA-inhibitory activity, and furthermore the double mutant aR61P/L62F lacked tPA-inhibitory activity, despite retaining the trypsin-inhibitory activity. In contrast, the mutant aA65Y exhibited tPA-inhibitory activity to the same extent as rETIa. This result suggests that Arg61 and Leu62 in ETIa, in addition to Arg63, may play an important role in the interaction with tPA.
WRA: A 2.2-to-6.3 TOPS Highly Unified Dynamically Reconfigurable Accelerator Using a Novel Winograd Decomposition Algorithm for Convolutional Neural Networks (2019)

As convolutional neural networks (CNNs) become more and more diverse and complicated, acceleration of CNNs increasingly encounters a bottleneck of balancing performance, energy efficiency, and flexibility in a unified architecture. This paper proposed a Winograd-based highly efficient and dynamically Reconfigurable Accelerator (named WRA) for quickly evolving CNN models. A cost-effective convolution decomposition method (CDW) was proposed, and it extends the application of the fast Winograd algorithm. Based on CDW, a high-throughput and reconfigurable processing element (PE) array was designed to exploit the parallelism of Winograd. Besides, a highly compact memory structure employed four levels of data reuse schemes to achieve maximal data reuse and minimize external bandwidth requirement. Provided with dynamically reconfigurable capability, WRA implements CDW and other convolutions (e.g., standard convolution, depthwise separable convolution, and group convolution) on a unified hardware architecture. The WRA accelerator was implemented on a Xilinx XCVU9P platform running at 330 MHz clock frequency, controlled by a POWER8 processor via a coherent accelerator processor interface (CAPI) interface. At different configurations, WRA can provide 2.2-6.3 TOPS performance for different convolution shapes. The average performance and energy efficiency for VGG16/AlexNet/MobileNetV1/MobileNetV2 are 5288 GOP/s at 151.2 GOPs/W, 3478 GOP/s at 99.4 GOPs/W, 2674 GOP/s at 76.4 GOPs/W, and 2194 GOP/s at 62.7 GOPs/W. It achieves $1.7\times $ -$24\times $ speedup compared with the previous FPGA-based designs.
CT angiography with electrocardiographically gated reconstruction for visualizing pulsation of intracranial aneurysms: identification of aneurysmal protuberance presumably associated with wall thinning. (2005)

Electrocardiographically (ECG) gated multisection helical CT images were obtained in 23 patients with ruptured intracranial aneurysms. 4D-CTA (3D CT angiography plus phase data) images were generated by ECG-gated reconstruction. Four patients showed pulsation of an aneurysmal bleb. Clipping was performed in two of these patients, and the rupture site matched the pulsatile bleb seen in 4D-CTA.
Pharmacological studies on antidiarrheal effects of a preparation containing Berberine and Geranii Herba. (1993)

We studied the effects of a preparation containing Berberine and Geranii Herba (BGH) on different diarrheal models of mice and the contractions of isolated guinea pig intestinal smooth muscle, comparing these effects with those of a preparation containing creosote (CSG) and loperamide (LP). BGH, as well as CSG and LP, significantly inhibited the diarrhea induced by castor oil or BaCl2, but not the diarrhea induced by pilocarpine or serotonin. BGH inhibited ACh-, Ba(2+)- or electrical stimulation (ES)-induced contraction of the ileum or colon at concentrations from 10(-6) to 10(-4) g/ml. On the other hand, the inhibitory effect of CSG on the ES-induced contraction was about one hundred times stronger than that on ACh- or Ba(2+)-induced contraction. The order of the inhibitory potency of LP on contractions of the ileum in this test was ES > Ba2+ > ACh, and LP showed stronger inhibition against the contraction of the ileum than that of the colon. These results suggest that BGH exerts its antidiarrheal action by inhibiting intestinal movement, and the mechanism of action of BGH may differ from those of CSG or LP.
Response to Open Peer Commentaries on “Strangers at the Beachside: Research Ethics Consultation” (2008)

Institutional ethics consultation services for biomedical scientists have begun to proliferate, especially for clinical researchers. We discuss several models of ethics consultation and describe a team-based approach used at Stanford University in the context of these models. As research ethics consultation services expand, there are many unresolved questions that need to be addressed, including what the scope, composition, and purpose of such services should be, whether core competencies for consultants can and should be defined, and how conflicts of interest should be mitigated. We make preliminary recommendations for the structure and process of research ethics consultation, based on our initial experiences in a pilot program.
USPHS/IDSA Guidelines for the Prevention of Opportunistic Infections in Persons Infected with Human Immunodeficiency Virus: Introduction (1995)

Journal Article USPHS/IDSA Guidelines for the Prevention of Opportunistic Infections in Persons Infected with Human Immunodeficiency Virus: Introduction Get access Jonathan E. Kaplan, Jonathan E. Kaplan Correspondence: Dr. Jonathan E. Kaplan, Division of HIV/AIDS, Mailstop G-29, Centers for Disease Control and Prevention, Atlanta, Georgia 30333. Search for other works by this author on: Oxford Academic PubMed Google Scholar Henry Masur, Henry Masur Search for other works by this author on: Oxford Academic PubMed Google Scholar King K. Holmes, King K. Holmes Search for other works by this author on: Oxford Academic PubMed Google Scholar Michael M. McNeil, Michael M. McNeil Search for other works by this author on: Oxford Academic PubMed Google Scholar Lawrence B. Schonberger, Lawrence B. Schonberger Search for other works by this author on: Oxford Academic PubMed Google Scholar Thomas R. Navin, Thomas R. Navin Search for other works by this author on: Oxford Academic PubMed Google Scholar Debra L. Hanson, Debra L. Hanson Search for other works by this author on: Oxford Academic PubMed Google Scholar Peter A. Gross, Peter A. Gross Search for other works by this author on: Oxford Academic PubMed Google Scholar Harold W. Jaffe, Harold W. Jaffe Search for other works by this author on: Oxford Academic PubMed Google Scholar the USPHS/IDSA Prevention of Opportunistic Infections Working Group the USPHS/IDSA Prevention of Opportunistic Infections Working Group Search for other works by this author on: Oxford Academic PubMed Google Scholar Clinical Infectious Diseases, Volume 21, Issue Supplement_1, August 1995, Pages S1–S11, https://doi.org/10.1093/clinids/21.Supplement_1.S1 Published: 01 August 1995
Synthesis of Furan- and Pyrrole-containing a-Oligothiophenes via 1,4-Diketones (1994)

Cyclization of the 1,4-dithienyl-1,4-diketones (3) by acid catalyst furnished the a-thienylfurans, whereas condensation with ammonium acetate provided the a-thienylpyrroles.The 2,5-bis[4-(2thienyll-1,4-butanedionyllthiophene (5) similarly gave the first syntheses of 2,5-bis[2-(5,2'-thieny1)pyrryllthiophene (12) and 2,5-bisL2-(5,2'-thieny1)furyllthiophene (13).Thiophene oligomers have continually attracted much attention due to their biological a c t i ~i t i e s ~, ~ and as starting materials for the preparation of organic conducton.3.4Nevertheless, oligomers of
Correcting the detrimental effects of nonuniform intensity distribution on fiber-transmitting laser speckle imaging of blood flow (2011)

Laser speckle spatial contrast analysis (LSSCA) is superior to laser speckle temporal contrast analysis (LSTCA) in monitoring the fast change in blood flow due to its advantage of high temporal resolution. However, the application of LSSCA which is based on spatial statistics may be limited when there is nonuniform intensity distribution such as fiber-transmitting laser speckle imaging. In this study, we present a normalized laser speckle spatial contrast analysis (nLSSCA) to correct the detrimental effects of nonuniform intensity distribution on the spatial statistics. Through numerical simulation and phantom experiments, it is found that just ten frames of dynamic laser speckle images are sufficient for nLSSCA to achieve effective correction. Furthermore, nLSSCA has higher temporal resolution than LSTCA to respond the change in velocity. LSSCA, LSTCA and nLSSCA are all applied in the fiber-transmitting laser speckle imaging system to analyze the change of cortical blood flow (CBF) during cortical spreading depression (CSD) in rat cortex respectively, and the results suggest that nLSSCA can examine the change of CBF more accurately. For these advantages, nLSSCA could be a potential tool for fiber-transmitting/endoscopic laser speckle imaging.
Development of thermoregulating textile materials with microencapsulated phase change materials (PCM). II. Preparation and application of PCM microcapsules (2005)

Abstract Melamine–formaldehyde microcapsules containing eicosane were prepared by in situ polymerization. The characterization of the microcapsules, including the particle size and size distribution, morphology, thermal properties, and stability, was carried out. The prepared microcapsules were added to polyester knit fabrics by a conventional pad–dry–cure process to develop thermoregulating textile materials. The morphology, thermal properties, and laundering properties of the treated fabrics were also investigated. The microcapsules were spherical and had melamine–formaldehyde shells containing eicosane. The microcapsules were strong enough to secure capsule stability under stirring in hot water and alkaline solutions. The heat storage capacity increased as the concentration of the microcapsules increased. The thermoregulating fabrics had heat storage capacities of 0.91–4.44 J/g, which depended on the concentration of the microcapsules. The treated fabrics retained 40% of their heat storage capacity after five launderings. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci 96: 2005–2010, 2005
Development of Surface Acoustic Wave-Based Microgyroscope Utilizing Progressive Wave (2010)

An 80 MHz surface acoustic wave (SAW)-based gyroscope utilizing a progressive wave was developed on a 128° YX LiNbO 3 piezoelectric substrate. The sensor developed consists of two SAW oscillators in which one is used as the sensing element and has metallic dots in the cavity between input and output interdigital transducers (IDTs). The other is used as the reference element. Coupling of modes (COM) modeling was conducted to determine the optimal device parameters prior to fabrication. On the basis of the simulation results, the device was fabricated and then measured on a rate table. When the device was subjected to an angular rotation, oscillation frequency differences between the two oscillators were observed because of the Coriolis force acting on the metallic dots. Depending on the angular velocity, the difference in oscillation frequency was modulated. The obtained sensitivity was approximately 52.35 Hz deg -1 s -1 at an angular rate range of 0–1000 deg/s. Device performances at different mass weights, mass positions, and temperatures were characterized. Good thermal stability was also observed during the evaluation process.
Evaluation of some acylamide derivatives as potential hypoglycemic agents. (1997)

A series of new acylamide derivatives with piperidine, pyrrolidinyl and alanyl have been tested for their hypoglycemic activities. 2-(Pyrrolidynyl)-N-(3-chlorophenyl) acetamide and 2-(Piperazinyl)-N-(4-methoxy phenyl) acetamide were found most active hypoglycemic compounds. Probably the amides have mode of action similar to sulphonylureas.