gebhart/patrepeval huggingface dataset:
Does wild-type p53 play a role in normal cell differentiation? (1994)

Inactivation of the p53 tumor suppressor gene plays a major role in malignant transformation. The central question in this issue is concerned with the understanding of the function of p53 in normal cells and its deregulation in cancer cells. Several in vitro and in vivo experimental models have indicated that induction of cells to undergo differentiation involve up-regulation in the expression of the p53. In the case of B cell differentiation, p53 was found to be involved in several steps of the differentiation pathway. The conclusion that p53 plays a role in normal development and differentiation in vivo is substantiated by the observation that p53 is expressed during embryonic development and is detected at low levels in a number of organs of adult mice. Accentuated levels of p53 in testes of adult mice, suggests that p53 plays a role in the meiotic process of spermatogenesis. B cell differentiation and spermatogenesis are biological pathways which normally involve DNA reshuffling and rearrangements. In accordance with the notion that p53 is associated with DNA repair it is tempting to speculate that at least in these physiological pathways p53 functions as a master gene that controls genome integrity.
Video captioning with recurrent networks based on frame- and video-level features and visual content classification (2015)

In this paper, we describe the system for generating textual descriptions of short video clips using recurrent neural networks (RNN), which we used while participating in the Large Scale Movie Description Challenge 2015 in ICCV 2015. Our work builds on static image captioning systems with RNN based language models and extends this framework to videos utilizing both static image features and video-specific features. In addition, we study the usefulness of visual content classifiers as a source of additional information for caption generation. With experimental results we show that utilizing keyframe based features, dense trajectory video features and content classifier outputs together gives better performance than any one of them individually.
Developmental Requirement of gp130 Signaling in Neuronal Survival and Astrocyte Differentiation (1999)

gp130 is a signal-transducing receptor component used in common by the interleukin-6 (IL-6) family of hematopoietic and neurotrophic cytokines, including IL-6, IL-11, leukemia-inhibitory factor, ciliary neurotrophic factor, oncostatin-M, and cardiotrophin-1. We have examined in this study a role of gp130 in the nervous system by analyzing developmental cell death of several neuronal populations and the differentiation of astrocytes in gp130-deficient mice. A significant reduction was observed in the number of sensory neurons in L5 dorsal root ganglia and motoneurons in the facial nucleus, the nucleus ambiguus, and the lumbar spinal cord in gp130 -/- mice on embryonic day 18.5. On the other hand, no significant neuronal loss was detectable on day 14.5, suggesting a physiological role of gp130 in supporting newly generated neurons during the late phase of development when naturally occurring cell death takes place. Moreover, expression of an astrocyte marker, GFAP, was severely reduced in the brain of gp130 -/- mice. Our data demonstrate that gp130 expression is essential for survival of subgroups of differentiated motor and sensory neurons and for the differentiation of major populations of astrocytes in vivo.
Purification and Functional Characterization of the C-Terminal Half of the Lactose Permease of <i>Escherichia coli</i> (1996)

The lactose permease has been expressed in contiguous, non-overlapping polypeptide fragments containing the N-terminal (N6) and C-terminal (C6) transmembrane domains of the protein [Bibi, E., & Kaback, H. R. (1990) Proc. Natl. Acad. Sci. U.S.A. 87, 4325; Zen, K., et al. (1994) Biochemistry 33, 8198]. When expressed individually, N6 and C6 are unstable and do not catalyze active transport. However, when expressed simultaneously, the polypeptides stabilize each other and form a complex that catalyzes active lactose transport. Moreover, a deletion construct containing the first transmembrane domain and the six C-terminal transmembrane domains mediates downhill lactose translocation [Bibi et al. (1991) proc. Natl. Acad. Sci. U.S.A. 88, 7271]. Here we report that C6 can be expressed independently in a relatively stable form that binds monoclonal antibodies 4B1 and 4B11, which interact with conformationally dependent epitopes on the periplasmic and cytoplasmic surfaces of the membrane, respectively. In addition, C6 retains the ability to catalyze lactose translocation down a concentration gradient in a specific manner. Finally, as observed with full-length Val331Cys permease, beta-D-galactopyranosyl 10thio-beta-D-galactopyranoside quenches the fluorescence of 2-(4'-maleimidylanilino)naphthalene- 6-sulfonic acid (MIANS)- labeled C6 with a single-Cys residue in place of Val331, exhibiting as apparent Kd of 0.2 mM. Unlike full-length Val331Cys permease, however, ligand does not induce a chance in the position of the emission maximum of MIANS-labeled C6(Val331Cys) permease not in the reactivity of C6 (Val331Cys) permease with MINAS. the results indicate that C6 retains a conformation similar to that on the native permease and that most of the structure required of high-affinity binding and substrate translocation is located in the C-terminal half of the molecule.
On the power of simple branch prediction analysis (2007)

Very recently, a new software side-channel attack, called Branch Prediction Analysis (BPA) attack, has been discovered and also demonstrated to be practically feasible on popular commodity PC platforms. While the above recent attack still had the flavor of a classical timing attack against RSA, where one uses many execution-time measurements under the same key in order to statistically amplify some small but key-dependent timing differences, we dramatically improve upon the former result. We prove that a carefully written spy-process running simultaneously with an RSA-process, is able to collect during one single RSA signing execution almost all of the secret key bits. We call such an attack, analyzing the CPU's Branch Predictor states through spying on a single quasi-parallel computation process, a Simple Branch Prediction Analysis (SBPA) attack --- sharply differentiating it from those one relying on statistical methods and requiring many computation measurements under the same key. The successful extraction of almost all secret key bits by our SBPA attack against an openSSL RSA implementation proves that the often recommended blinding or so called randomization techniques to protect RSA against side-channel attacks are, in the context of SBPA attacks, totally useless. Additional to that very crucial security implication, targeted at such implementations which are assumed to be at least statistically secure, our successful SBPA attack also bears another equally critical security implication. Namely, in the context of simple side-channel attacks, it is widely believed that equally balancing the operations after branches is a secure countermeasure against such simple attacks. Unfortunately, this is not true, as even such "balanced branch" implementations can be completely broken by our SBPA attacks. Moreover, despite sophisticated hardware-assisted partitioning methods such as memory protection, sandboxing or even virtualization, SBPA attacks empower an unprivileged process to successfully attack other processes running in parallel on the same processor. Thus, we conclude that SBPA attacks are much more dangerous than previously anticipated, as they obviously do not belong to the same category as pure timing attacks.
Variations of the Similarity Function of TextRank for Automated Summarization (2016)

This article presents new alternatives to the similarity function for the TextRank algorithm for automatic summarization of texts. We describe the generalities of the algorithm and the different functions we propose. Some of these variants achieve a significative improvement using the same metrics and dataset as the original publication.
Tissue Injury in Inflammation. Oxidants, Proteinases, and Cationic Proteins (1987)

No AccessJournal of Urology1 Sep 1987Tissue Injury in Inflammation. Oxidants, Proteinases, and Cationic Proteins P.M. Henson and R.B. Johnston P.M. HensonP.M. Henson More articles by this author and R.B. JohnstonR.B. Johnston More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)43303-9AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Tissue Injury in Inflammation. Oxidants, Proteinases, and Cationic Proteins." The Journal of Urology, 138(3), p. 682 © 1987 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 138Issue 3September 1987Page: 682 Advertisement Copyright & Permissions© 1987 by The American Urological Association Education and Research, Inc.MetricsAuthor Information P.M. Henson More articles by this author R.B. Johnston More articles by this author Expand All Advertisement PDF downloadLoading ...
The ALDMOST: A new power MOS transistor (1987)

A new lateral power MOSFET structure, named the Accumulation LDMOST (ALDMOST), is proposed. It relies on creation of an accumulation layer along the surface of the drift region. This surface accumulation layer exists only in the ON state. Simulation studies indicate that the product of the ON resistance by the area ( <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">R_{on}.A</tex> ) of the ALDMOST is one-third to one-fifth that of a conventional LDMOST rated at the same breakdown voltage.
Engineered catalytic biofilms: Site‐specific enzyme immobilization onto <i>E. coli</i> curli nanofibers (2015)

Biocatalytic transformations generally rely on purified enzymes or whole cells to perform complex transformations that are used on industrial scale for chemical, drug, and biofuel synthesis, pesticide decontamination, and water purification. However, both of these systems have inherent disadvantages related to the costs associated with enzyme purification, the long-term stability of immobilized enzymes, catalyst recovery, and compatibility with harsh reaction conditions. We developed a novel strategy for producing rationally designed biocatalytic surfaces based on Biofilm Integrated Nanofiber Display (BIND), which exploits the curli system of E. coli to create a functional nanofiber network capable of covalent immobilization of enzymes. This approach is attractive because it is scalable, represents a modular strategy for site-specific enzyme immobilization, and has the potential to stabilize enzymes under denaturing environmental conditions. We site-specifically immobilized a recombinant α-amylase, fused to the SpyCatcher attachment domain, onto E. coli curli fibers displaying complementary SpyTag capture domains. We characterized the effectiveness of this immobilization technique on the biofilms and tested the stability of immobilized α-amylase in unfavorable conditions. This enzyme-modified biofilm maintained its activity when exposed to a wide range of pH and organic solvent conditions. In contrast to other biofilm-based catalysts, which rely on high cellular metabolism, the modified curli-based biofilm remained active even after cell death due to organic solvent exposure. This work lays the foundation for a new and versatile method of using the extracellular polymeric matrix of E. coli for creating novel biocatalytic surfaces.
Natural selection on <i>EPAS1</i> ( <i>HIF2α</i> ) associated with low hemoglobin concentration in Tibetan highlanders (2010)

By impairing both function and survival, the severe reduction in oxygen availability associated with high-altitude environments is likely to act as an agent of natural selection. We used genomic and candidate gene approaches to search for evidence of such genetic selection. First, a genome-wide allelic differentiation scan (GWADS) comparing indigenous highlanders of the Tibetan Plateau (3,200-3,500 m) with closely related lowland Han revealed a genome-wide significant divergence across eight SNPs located near EPAS1. This gene encodes the transcription factor HIF2alpha, which stimulates production of red blood cells and thus increases the concentration of hemoglobin in blood. Second, in a separate cohort of Tibetans residing at 4,200 m, we identified 31 EPAS1 SNPs in high linkage disequilibrium that correlated significantly with hemoglobin concentration. The sex-adjusted hemoglobin concentration was, on average, 0.8 g/dL lower in the major allele homozygotes compared with the heterozygotes. These findings were replicated in a third cohort of Tibetans residing at 4,300 m. The alleles associating with lower hemoglobin concentrations were correlated with the signal from the GWADS study and were observed at greatly elevated frequencies in the Tibetan cohorts compared with the Han. High hemoglobin concentrations are a cardinal feature of chronic mountain sickness offering one plausible mechanism for selection. Alternatively, as EPAS1 is pleiotropic in its effects, selection may have operated on some other aspect of the phenotype. Whichever of these explanations is correct, the evidence for genetic selection at the EPAS1 locus from the GWADS study is supported by the replicated studies associating function with the allelic variants.
Molecular mechanisms of opiate and cocaine addiction (1997)

Chronic administration of opiates or cocaine has been shown to alter the activity or expression of diverse types of cellular proteins in specific target neurons within the central nervous system. Prominent examples include signaling proteins, such as receptors, G proteins, second-messenger synthetic enzymes, and protein kinases. It is now increasingly possible to relate particular molecular adaptations to specific behavioral actions of drugs of abuse in animal models of addiction. In addition, recent work has focused on a role for transcription factors, and the associated alterations in gene expression, in mediating part of this long-lasting, drug-induced molecular and behavioral plasticity.
An inhibitor of the acetyltransferases CBP/p300 exerts antineoplastic effects on gastrointestinal stromal tumor cells (2016)

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasm featured by activated mutations of KIT and PDGFRA. Although overall survival rates have greatly improved by the development of receptor tyrosine kinase inhibitors, most patients ultimately acquire resistance due to secondary mutations of KIT or PDGFRA. Inhibition of the histone acetyltransferases (HATs) CREB‑binding protein (CBP) and p300 results in antineoplastic effects in various cancers. To determine whether CBP/p300 can serve as an antineoplastic target for GISTs, specific short interfering RNA sequences and the selective HAT inhibitor C646 were administered to GIST882 cells. Cell viability, apoptosis and the cell cycle were analysed using the Cell Counting Kit-8, a caspase-3/7 activity assay or Annexin V-fluorescein isothiocyanate/propidium iodide (PI) staining and PI staining. Gene and protein expression levels were measured by quantitative real-time polymerase chain reaction and western blotting, respectively. Transcriptional blockage of CBP, rather than p300, resulted in suppression of cell proliferation. Interestingly, both CBP and p300 depletion enhanced caspase-3/7 activity. A lack of CBP and p300 caused ETS translocation variant 1 (ETV1) downregulation and KIT inhibition in GIST cells. Nevertheless, the absence of CBP, not p300, leads to extracellular signal-regulated kinase 1/2 inactivation and c-Jun NH2-terminal kinase activation, suggesting a more crucial role for CBP than p300 in cell proliferation and survival. Furthermore, proliferation of GIST cells was reduced by administration of C646, a selective HAT inhibitor for CBP/p300. Apoptosis induction and cell cycle arrest were detected after exposure to C646, indicating that its antitumor activities were supported by its antiproliferative and proapoptotic effects. Additionally, C646 treatment attenuated ETV1 protein expression and inactivated KIT-dependent pathways. Taken together, the present study suggests that CBP/p300 may serve as novel antineoplastic targets and that use of the selective HAT inhibitor C646 is a promising antitumor strategy for GISTs.
La enseñanza de las matemáticas en las universidades (1954)

El siguiente es el bosquejo de una conferencia dictada hace algún tiempo por el autor en una sesión común de la Sociedad Matemática de Nancago y de la Asociación Matemática de Poldavia. Se publica aquí, a petición del editor, ya que los principios establecidos en ella parecen ser de aplicación general
Historietistas latinoamericanos en otros mercados, razones para el exilio. El caso de Argentina (2014)

espanolLos paises latinoamericanos han atravesado periodos de crisis politica y economica que ha afectado a la industria de sus publicaciones, entre ellas las de historietas. En el presente ensayo se revisa el caso de Argentina, cuyos autores publicaron sus obras episodicamente en un clima de falta de libertades, totalmente represivo tras la instauracion del llamado Proceso. En el presente ensayo se concluye que las migraciones de argentinos hacia otros mercados del comic fueron motivadas por razones economicas antes que politicas, que los casos de critica al gobierno militar practicados desde el interior fueron timidos, y se hicieron desde la metafora o la satira, y que los autores exilados por razones aparentemente ideologicas ejercitaron una suerte de olvido de las atrocidades cometidas durante la dictadura militar sin interesarse abiertamente por elaborar historietas de denuncia. EnglishThe periods of political and economic crisis in Latin American countries have affected the industry of its publications of comics. We review the case of Argentina, whose authors published their works occasionally in a climate of lack of freedoms, totally repressive with the introduction of the so-called Proceso. We conclude that migration into other markets of comics was motivated by economic reasons rather than political; that the criticism to the military governments were timid, and were made from the metaphor or satire; and that the exiled authors (by apparently ideological reasons) preferred not to work directly about the atrocities committed during the military dictatorship and developed only some mild complaints in vignettes.
The Nurse in Pediatric Critical Care (2006)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Fabrication of half-pitch 32nm resist patterns using near-field lithography with a-Si mask (2006)

We evaluated the performances of Cr and amorphous Si (a-Si) films as light absorber materials for photomasks of near-field lithography on the basis of numerical studies using finite-difference time domain method and experimental results of fabrication process. With exposure experiments using both a Cr mask and an a-Si mask, fine performance of an a-Si near-field mask was demonstrated with respect to resolution. A half-pitch 32nm resist pattern of 120nm high was fabricated through the near-field lithography using the a-Si mask and a subsequent trilayer resist process.
SYNERGISM IN FLAME EXTINGUISHMENT: NEW RESULTS FOR MIXTURES OF PHYSICAL AND CHEMICAL AGENTS (1997)

Flame extinguishment results for mixtures of physical and chemical agents have been obtained with a new total flooding apparatus. Mixtures of agents that operate primarily through enthalpic (heat capacity, phase change) effects and radical chain stoppers show pronounced synergism. The enhancement in flame suppression occurring in mixtures is predictable with a simple model employing an Arrhenius-type equation to account for the steady state concentration of free radicals in the flame and adiabatic flame temperature calculations using heat capacities of agents and other gases in the combustion chamber. The advantage of synergism in fire fighting is that chemical agents approved for fire suppression use can be employed in mixtures with the much safer physical agents, so that the required amounts of both agents are greatly reduced. The new testing procedure makes it possible to study the flame suppression ability of agents having partial pressures under ambient conditions of only a few torr or less, yielding percentages of individual agents or agent mixtures required for flame suppression in total flooding and related applications. Results are quite consistent with those obtained in standard cup-burner tests. Predictions can be made of the compositions of mixtures of physical agents (including COz, inert gases, FM200, and water) and chemical agents (the halons, iodinated or brominated HFC’s, metal carbonyls, and halogenated methanes) required to suppress flames.
Vitis: A Gossip-based Hybrid Overlay for Internet-scale Publish/Subscribe Enabling Rendezvous Routing in Unstructured Overlay Networks (2011)

Peer-to-peer overlay networks are attractive solutions for building Internet-scale publish/subscribe systems. However, scalability comes with a cost: a message published on a certain topic often needs to traverse a large number of uninterested (unsubscribed) nodes before reaching all its subscribers. This might sharply increase resource consumption for such relay nodes (in terms of bandwidth transmission cost, CPU, etc) and could ultimately lead to rapid deterioration of the system's performance once the relay nodes start dropping the messages or choose to permanently abandon the system. In this paper, we introduce Vitis, a gossip-based publish/subscribe system that significantly decreases the number of relay messages, and scales to an unbounded number of nodes and topics. This is achieved by the novel approach of enabling rendezvous routing on unstructured overlays. We construct a hybrid system by injecting structure into an otherwise unstructured network. The resulting structure resembles a navigable small-world network, which spans along clusters of nodes that have similar subscriptions. The properties of such an overlay make it an ideal platform for efficient data dissemination in large-scale systems. We perform extensive simulations and evaluate Vitis by comparing its performance against two base-line publish/subscribe systems: one that is oblivious to node subscriptions, and another that exploits the subscription similarities. Our measurements show that Vitis significantly outperforms the base-line solutions on various subscription and churn scenarios, from both synthetic models and real-world traces.
A Clue to Antigen Receptor Tails (2014)

In science, context is essential for interpreting and integrating new observations into current paradigms. Without sufficient context, the significance of an important or insightful discovery may go unrealized until additional information is gleaned that brings its value to light. One such example
Short Notices (1968)

Journal Article Short Notices Get access J. C. G. RÖHL J. C. G. RÖHL University of Sussex Search for other works by this author on: Oxford Academic Google Scholar The English Historical Review, Volume LXXXIII, Issue CCCXXVI, January 1968, Pages 222-c–223, https://doi.org/10.1093/ehr/LXXXIII.CCCXXVI.222-c Published: 01 January 1968