gebhart/patrepeval huggingface dataset:
Estimating The Driver’S Workload: Using Smartphone Data To Adapt In-Vehicle Information Systems (2015)

Research Question: How can the driver’s workload be estimated in order to<br> adapt information and entertainment systems?<br> Approach: Smartphone sensor data, situational factors and basic user characteristics<br> are collected. This data is tested whether it significantly influences<br> workload and can be used to estimate it.<br> Method: Workload is measured with a smartphone-based representation of<br> the NASA-TLX and the RSME during a user study with 20 participants on<br> different road types.<br> Results: Driving situation, gender and driving frequency significantly influence<br> workload. Using only this information and smartphone sensor data<br> the driver’s current workload can be estimated with 86% accuracy using a<br> decision tree.
Reversal of warfarin-induced anticoagulation with factor VIIa prior to rt-PA in acute stroke (2005)

Thrombolytics for stroke are contraindicated if a patient’s prothrombin time (PT) is above 15. Recombinant factor VII (rVIIa) has been approved for the rapid reversal of warfarin-induced coagulopathy. Since rVIIa can reverse coagulopathy quickly, it might be useful to correct PT elevations in patients who are eligible for thrombolytics.

A 71-year-old, right-handed woman with a history of left hemispheric ischemic stroke presented to our emergency department with new onset of left arm and leg weakness, facial droop, visual field blurring, and dysarthria. The symptoms began initially at 9:15 am and en route to the hospital, she became quadriplegic. Upon arrival, the patient was oriented and had mild dysarthria and bilateral facial droop, left greater than right. Strength was 0/5 in all extremities and deep tendon reflexes were 2+ in the right limbs and 1+ in the left. NIH Stroke Scale score was 20.

The patient’s previous ischemic …
Active and Passive Side-Channel Attacks on Delay Based PUF Designs. (2014)

have emerged as a lightweight alternative to traditional cryptography. The fact that no secret key needs to be stored in non-volatile memory makes PUFs especially well suited for embedded systems in which securely generating and storing secret keys is difficult and ex-pensive. Compared to traditional cryptography, PUFs are often believed to be more resistant to implementa-tion attacks. In this paper we will take a closer look at this assumption. Using a controlled Arbiter PUF as an example, we show that just like traditional cryptog-raphy strong PUFs are susceptible to implementation attacks. By combining machine learning with with side-channel analysis we are able to attack designed based on Arbiter PUFs that on are resistant to normal machine learning attacks. We use two different side-channels for our attacks: a passive power side-channel and an active fault attack based on altering the supply voltage of the controlled PUF. Even in the presence of considerable noise both attacks can accurately model the Controlled Arbiter PUF. Hence, the assumption that PUFs are generally more resistant against side-channel attacks is not necessarily true and side-channel resistance needs to be considered when PUF designs are evaluated. Index Terms—Side-channel analysis, machine learn-ing, Physical Unclonable Function, Arbiter-PUF, fault attack, CPA I.
Progranulin deficiency leads to reduced glucocerebrosidase activity (2019)

Mutation in the GRN gene, encoding the progranulin (PGRN) protein, shows a dose-dependent disease correlation, wherein haploinsufficiency results in frontotemporal lobar degeneration (FTLD) and complete loss results in neuronal ceroid lipofuscinosis (NCL). Although the exact function of PGRN is unknown, it has been increasingly implicated in lysosomal physiology. Here we report that PGRN interacts with the lysosomal enzyme, glucocerebrosidase (GCase), and is essential for proper GCase activity. GCase activity is significantly reduced in tissue lysates from PGRN-deficient mice. This is further evidence that reduced lysosomal hydrolase activity may be a pathological mechanism in cases of GRN-related FTLD and NCL.
A theoretical study on formation shear radial profiling in well-bonded cased boreholes using sonic dispersion data based on a parameterized perturbation model (2012)

ABSTRACT Interpretation of sonic data can be challenging in the presence of a steel casing that has a strong influence on elastic waves propagating along a borehole. The cement annulus behind the casing together with drilling-induced near-wellbore alteration causes radial heterogeneity in the propagating medium. It is necessary to study the influence of such heterogeneities on borehole waves and estimate the radial extent of near-wellbore alteration in terms of radial variation of velocities away from the casing. To this end, we based our study on the model of a fluid-filled well-bonded cased borehole surrounded by a cylindrically layered formation. The formation is isotropic and purely elastic, and can be either fast or slow. Borehole monopole and dipole dispersions for this kind of model can be obtained from a root finding mode-search routine. A modified perturbation model based on Hamilton’s principle is used to predict changes in borehole dispersions caused by formation heterogeneities. A two-layer formation model as the reference state is introduced, which always provides normal dispersive reference dispersion for calculations of perturbation integrals for fast and slow formations. Radial variations of the formation shear velocity can be expressed in terms of a parametric exponential profile. Consequently, estimation of these parameters in the assumed profile yields the radial variation of the formation shear slowness away from the casing. Numerical results using synthetic examples are presented to demonstrate the validity of this radial profiling methodology.
Graduate student use of a multi-slate reading system (2013)

In laboratory studies, multi-surface slate-based reading systems have shown great promise as platforms for active reading. However, the true utility of such a system can only be ascertained through the rigors of real world use. We conducted month-long deployments of a multi-slate reading system to support the active reading activities of graduate students in the humanities. During these deployments we documented how the added display area and increased micro-mobility of multiple devices enhanced navigation and reading comfort. We also noted the essential role of writing and annotation. Finally, we observed how electronic affordances like synchronization across devices helped provide functionality that would not have been possible with paper documents. This paper contributes new information about how electronic reading solutions fit into real world reading workflows.
Possible regulatory role for nonaromatic carbon sources in styrene degradation by Pseudomonas putida CA-3 (1995)

Styrene metabolism in styrene-degrading Pseudomonas putida CA-3 cells has been shown to proceed via styrene oxide, phenylacetaldehyde, and phenylacetic acid. The initial step in styrene degradation by strain CA-3 is oxygen-dependent epoxidation of styrene to styrene oxide, which is subsequently isomerized to phenylacetaldehyde. Phenylacetaldehyde is then oxidized to phenylacetic acid. Styrene, styrene oxide, and phenylacetaldehyde induce the enzymes involved in the degradation of styrene to phenylacetic acid by P. putida CA-3. Phenylacetic acid-induced cells do not oxidize styrene or styrene oxide. Thus, styrene degradation by P. putida CA-3 can be subdivided further into an upper pathway which consists of styrene, styrene oxide, and phenylacetaldehyde and a lower pathway which begins with phenylacetic acid. Studies of the repression of styrene degradation by P. putida CA-3 show that glucose has no effect on the activity of styrene-degrading enzymes. However, both glutamate and citrate repress styrene degradation and phenylacetic acid degradation, showing a common control mechanism on upper pathway and lower pathway intermediates.
Effect of bovine lactoferricin on enteropathogenic Yersinia adhesion and invasion in HEp-2 cells (2004)

Bovine lactoferricin, a pepsin-generated antimicrobial peptide from bovine lactoferrin active against a wide range of bacteria, was tested for its ability to influence the adhesion and invasion of Yersinia enterocolitica and Yersinia pseudotuberculosis in HEp-2 cells. The addition of non-cytotoxic and non-bactericidal concentrations of lactoferricin to cell monolayers before infection, under different bacterial growth experimental conditions, was ineffective or resulted in about a 10-fold increase in bacterial adhesion, whereas, in bacteria grown in conditions allowing maximal inv gene expression, a 10-fold inhibition of cell invasion by lactoferricin was observed. To confirm that the anti-invasive activity of lactoferricin was exerted against invasin-mediated bacterial entry, experiments were also performed utilizing Escherichia coli strain HB101 (pRI203), harbouring the inv gene from Y. pseudotuberculosis, which allows penetration of mammalian cells. Under these experimental conditions, lactoferricin was able to inhibit bacterial entry into epithelial cells, demonstrating that this peptide acts on inv-mediated Yersinia species invasion. As the inv gene product is the most important virulence factor in enteropathogenic Yersinia, being responsible for bacterial adherence and penetration within epithelial cells of the intestinal lumen and for the subsequent colonization of regional lymph nodes, these data provide additional information on the protective role of lactoferricin against bacterial infection.
Featured Media: Nonlinear, Clickable Multimedia Content for an Interactive Video Experience (2010)

Up till now, there is no convenient way for users to interact with any kind of video data or video content. Such interactions are known from internet data or computer games, which have a different data structure from video data. Video comprises filmed real scenes, or at least real scenes which are augmented by editing e.g. with a computer. It is the purpose of the present platform to provide a system and data structures, which allow a user initiated interaction with video data on TVs, Mobiles and the Web in a harmonized and easy way. This paper describes the realization of the above outlined user initiated content interaction to deliver value-added information, links and advertisements on-demand and in a personalized way. The envisioned solution will help to satisfy the ever-increasing demand of the content production as well as advertisement industry for predefined interfaces to place advertisements and product related information in close vicinity to particular objects within a scene.
Letter (1995)

Guy’s and St Thomas’s director of quality and nursing Wilma MacPherson provides yet another reminder of the shortage of nurses with the right backgrounds to occupy senior positions within the health service (New trust nursing directors lack suitable experience, Nursing Management news, issue no 6).
Enhanced aggregation and β structure of amyloid β peptide after coincubation with C1Q (1994)

Several lines of evidence now suggest that aggregation of soluble amyloid beta peptide (A beta) into a cross beta sheet configuration may be an important factor in mediating potential neurotoxicity of A beta. Synthetic A beta has been shown to self aggregate in vitro. Here, we demonstrate that coincubation of freshly solubilized A beta with C1q, a complement component known to bind A beta in vitro and to colocalize with A beta in vivo, results in as much as a 7-fold enhancement of A beta aggregation, as well as a 2-4-fold enhancement of beta structure within aggregates. The addition of C1q to preformed A beta aggregates also results in significantly increased resistance to aggregate resolubilization.
Lotus‐Effekt und Autolack: Die Selbstreinigungsfähigkeit mikrostrukturierter Oberflächen (1998)

Abstract Die heilige Lotusblume gilt in den asiatischen Religionen als Symbol der Reinheit: Makellos sauber entfalten sich die Blätter aus dem Schlamm der Gewässer. Dieses Phänomen der Selbstreinigung wurde im Detail untersucht und gewährt erstaunliche Einblicke in die Möglichkeiten der Natur, sich gegen den allgegenwärtigen Schmutz, aber auch gegen Pathogene zu wehren. Es zeigt sich darüber hinaus, daßlig; es möglich ist, künstliche Oberflächen mit vergleichbaren Eigenschaften zu entwickeln, etwa durch die Oberflächenbehandlung von Gebäudefassaden oder Autos, die selbst starkem Regen und Verschmutzungen standhalten oder beides abweisen. Dieses dürfte nur noch ein Frage der Zeit sein.
Stereospecific metabolism of isomeric epoxyoctadecanoic acids in the lactone‐producing yeast <i>Sporidiobolus salmonicolor</i> (1998)

The metabolic course of four isomeric epoxyfatty acids derived from oleic-, elaidic-, (Z)-, and (E)-vaccenic acids in the lactone-producing yeast, Sporidiobolus salmonicolor, was studied by using the deuterium-labeled precursors. Dihydroxy-, hydroxyoxo-, and hydroxy fatty acids as well as gamma-lactones were identified as metabolic intermediates. Quantitative analysis of the label content and estimation of the enantiomeric composition of the lactones established that, in the first step, the racemic epoxyfatty acids were enantiospecifically hydrolyzed by an epoxide hydrolase. During the subsequent metabolism, the stereochemical orientation of the hydroxy groups of the dihydroxyfatty acids were modified by an oxidation/reduction step.
Synthesis of cis-bicyclo(4.3.0)non-2-ene derivatives. The potent homoisocarbacyclin analogs. (1989)

Synthesis of homoisocarbacyclin has been achieved efficiently by a general strategy with stereo- and regiochemical control. One of homoisocarbacyclin derivatives, 3-oxa homoisocarbacyclin analog (4), was shown to be potently active in inhibiting gastric ulcer. Another analog, conjugated diene derivative (5), was found to have a biological profile similar to prostacyclin.
The cynomolgus monkey as a model for orbital research. III. Effects on ocular physiology of lateral orbitotomy and isolation of the ciliary ganglion (1984)

Five cynomolgus monkeys underwent unilateral lateral orbitotomy and isolation but not removal of the ciliary ganglion. Orbitotomized eyes were compared with untouched contralateral eyes with respect to intraocular pressure, aqueous humor formation rate, pupillary diameter and light reflex, corneal reflex, entry of intravenously administered fluorescein into the anterior chamber, anterior chamber volume, pharmacologically (pilocarpine, carbachol, echothiophate) induced accommodation, electroretinogram (ERG), visually evoked cortical response (VER), and clinical biomicroscopy, ophthalmoscopy, and fluorescein fundus angiography. Orbitotomized eyes accommodated significantly less than contralateral normal eyes in response to topical echothiophate one to two weeks after surgery. This difference was no longer present 15 to 20 weeks after orbitotomy. The implicit time on the light adapted ERG in the orbitotomized eyes was slightly but significantly shorter than in the normal eyes two to six weeks after orbitotomy; all the other ERG and VER parameters were the same in both eyes. Long-term ERG data were not obtained. There were no significant differences between normal and orbitotomized eyes with respect to any of the other parameters.
Angiogenesis in human coronary atherosclerotic plaques. (1994)

Neovascularization in the walls of coronary arteries is associated with the presence of atherosclerotic plaque. The mechanisms responsible for the formation of these intraplaque microvessels are not understood. The purpose of this study is to examine the prevalence of endothelial cell replication in plaque microvessels. Two hundred and one primary and restenotic coronary atherectomy specimens were analyzed for the presence of microvessels and proliferation as reflected by positive immunolabeling for Ulex agglutinin and the proliferating cell nuclear antigen, respectively. In primary but not restenotic specimens, proliferation of any cell type was associated with the detection of microvessels on the same slide. However, intraplaque microvessels were more commonly found in restenotic compared to primary specimens (P = 0.004). Twelve highly vascularized specimens with evidence of replication were subjected to detailed histomorphological and quantitative image analyses. At 200 x, the most vascular optical field of each slide was identified and consistently included plaque macrophages. Total slide endothelial cell replication indices for these specimens varied, but in some instances were remarkably elevated (eg, 43.5%). The role of intraplaque angiogenesis may be analogous to that of tumor or wound angiogenesis and be important in development and progression of coronary artery lesions and restenosis.
Quantitative immunoelectrophoretic analysis of the plasma proteins in the sol phase of sputum from patients with chronic bronchitis (1973)

An analysis of the plasma proteins in the sol phase of sputum was carried out using quantitative cross immunoelectrophoresis. The average concentrations of nine plasma proteins were estimated in the sol phase of sputum specimens from 30 patients with chronic bronchitis and the values were compared with the concentrations of these proteins in saliva and serum specimens from the same group of patients. The results showed that alpha(1) antichymotrypsin and IgA concentrations were higher in the sol phase of sputum than would be expected if their presence were due entirely to passive transudation.
TFG3/TAF30/ANC1, a Component of the Yeast SWI/SNF Complex That Is Similar to the Leukemogenic Proteins ENL and AF-9 (1996)

The SWI1/ADR6, SWI2/SNF2, SWI3, SNF5, and SNF6 gene products are all required for proper transcriptional control of many genes in the yeast Saccharomyces cerevisiae. Genetic studies indicated that these gene products might form a multiprotein SWI/SNF complex important for chromatin transitions preceding transcription from RNA polymerase II promoters. Biochemical studies identified a SWI/SNF complex containing these and at least six additional polypeptides. Here we show that the 29-kDa component of the SWI/SNF complex is identical to TFG3/TAF30/ANC1. Thus, a component of the SWI/SNF complex is also a member of the TFIIF and TFIID transcription complexes. TFG3 interacted with the SNF5 component of the SWI/SNF complex in protein interaction blots. TFG3 is significantly similar to ENL and AF-9, two proteins implicated in human acute leukemia. These results suggest that ENL and AF-9 proteins interact with the SNF5 component of the human SWI/SNF complex and raise the possibility that the SWI/SNF complex is involved in acute leukemia.
Diagnostic yield of a targeted gene panel in primary ciliary dyskinesia patients (2018)

We aimed to determine the diagnostic yield of a targeted-exome panel in a cohort of 74 Dutch primary ciliary dyskinesia (PCD) patients. The panel consisted of 26 PCD-related and 284 candidate genes. To prioritize PCD candidate genes, we investigated the transcriptome of human airway cells of 12 healthy volunteers during in vitro ciliogenesis and hypothesized that PCD-related genes show significant upregulation. We compared gene expression in epithelial precursor cells grown as collagen monolayer and ciliated cells grown in suspension by RNA sequencing. All genes reported as PCD causative, except NME8, showed significant upregulation during in vitro ciliogenesis. We observed 67.6% diagnostic yield when testing the targeted-exome panel in our cohort. There was relatively high percentage of DNAI and HYDIN mutations compared to other countries. The latter may be due to our solution for the problem of the confounding HYDIN2 pseudogene. Candidate genes included two recently published PCD-related genes DNAJB13 and PIH1D3; identification of the latter was a direct result of this study. In conclusion, we demonstrate 67.6% diagnostic yield by targeted exome sequencing in a Dutch PCD population and present a highly sensitive and moderately specific approach for identification of PCD-related genes, based on significant upregulation during in vitro ciliogenesis.
APOCS: a rapidly convergent source localization algorithm for sensor networks (2005)

This paper addresses the problem of locating an acoustic source using a sensor network in a distributed manner, i.e., without transmitting the full data set to a central point for processing. This problem has been traditionally addressed through the maximum likelihood framework or nonlinear least squares. These methods, even though asymptotically optimal under certain conditions, pose a difficult global optimization problem. It is shown that the associated objective function may have multiple local optima and hence local search methods might stagnate at a sub-optimal solution. In this paper, we treat the problem in its convex feasibility formulation. We propose the aggregated projection onto convex sets (APOCS) method, which, in contrast to the original POCS method, converges to a meaningful limit even when the problem is infeasible without requiring a diminishing step size. Simulation results show convergence to the global optimum with significantly faster convergence rates compared to the previous methods
Intratumoral Delivery of Interleukin 12 Expression Plasmids with <i>In Vivo</i> Electroporation Is Effective for Colon and Renal Cancer (2001)

We report on an antitumor treatment involving electrogene therapy (EGT), a newly developed in vivo gene transfer method using electroporation. We carried out in vivo EGT in a subcutaneous model of CT26 colon carcinoma cells, using plasmid DNAs encoding interleukin 12 (IL-12) subunits. For this purpose, we developed two IL-12 expression systems: a cotransfer system using a plasmid encoding the IL-12 p40 subunit and a plasmid encoding the IL-12 p35 subunit, and a single-vector system using a plasmid expressing a p40-p35 fusion protein. Both transfer systems significantly inhibited the growth of CT26 tumor. Immunohistochemical analysis of IL-12 EGT-treated tumors revealed enhanced infiltration of CD8(+) cells into the tumor tissue, while reverse transcriptase-polymerase chain reaction confirmed the increased expression of interferon gamma within treated tumors. The same IL-12 EGT applied to the nude mouse model was not effective, suggesting the critical role of T cell infiltration in this treatment. The inhibitory effects revealed in experiments in which previously treated mice were rechallenged with a second inoculation of CT26 tumor cells suggested that IL-12 EGT may also establish partial systemic antitumor immunity. The growth of IL-12 EGT-treated Renca tumors, a renal cell carcinoma, was also significantly inhibited. These findings suggest that EGT of the IL-12 gene has the potential to be an effective anticancer gene therapy.
A finite-difference time-domain method applied to anisotropic material (1993)

The popularity of the finite-difference time-domain (FDTD) method stems from the fact that it is not limited to a specific geometry and it does not restrict the constitutive parameters of a scatterer. Furthermore, it provides a direct solution to problems with transient illumination, but can also be used for harmonic analysis. However, researchers have limited their investigation to materials that are either isotropic or that have diagonal permittivity, conductivity, and permeability tensors. The authors derive the necessary extension to the FDTD equations to accommodate nondiagonal tensors. Excellent agreement between FDTD and exact analytic results is obtained for a one-dimensional anisotropic scatterer.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
La lingua basca in Spagna e in Francia : verso l’inclusione degli attivisti etnolinguistici ? (2010)

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