gebhart/patrepeval huggingface dataset:
Selective Pro-Apoptotic Activity of Novel 3,3′-(Aryl/Alkyl-Methylene)Bis(2-Hydroxynaphthalene-1,4-Dione) Derivatives on Human Cancer Cells via the Induction Reactive Oxygen Species (2016)

Selective induction of apoptosis in cancer cells barring the normal cells is considered as an effective strategy to combat cancer. In the present study, a series of twenty-two (22) synthetic 3,3'-(aryl/alkyl-methylene)bis(2-hydroxynaphthalene-1,4-dione) bis-lawsone derivatives were assayed for their pro-apoptotic activity in six different cell lines (five cancerous and one normal) using MTT assay. Out of these 22 test compounds, 1j was found to be the most effective in inducing apoptosis in human glioma cells (CCF-4) among the different cell lines used in the study. The activity of this compound, 1j, was then compared to a popular anticancer drug, cisplatin, having limited usage because of its nephrotoxic nature. In this study, 1j derivative showed much less toxicity to the normal kidney cells compared to cisplatin, thus indicating the superiority of 1j as a possible anticancer agent. This compound was observed to induce apoptosis in the glioma cells by inducing the caspase dependent apoptotic pathways via ROS and downregulating the PI3K/AKT/mTOR pathway. Estimation of different oxidative stress markers also confirms the induction of oxidative stress in 1j exposed cancer cells. The toxicity of 1j compound toward cancer cells was confirmed further by different flow cytometrical analyses to estimate the mitochondrial membrane potential and cell cycle. The sensitivity of malignant cells to apoptosis, provoked by this synthetic derivative in vitro, deserves further studies in suitable in vivo models. These studies not only identified a novel anticancer drug candidate but also help to understand the metabolism of ROS and its application in cancer treatment.
MIP-1alpha, MCP-1, GM-CSF, and TNF-alpha control the immune cell response that mediates rapid phagocytosis of myelin from the adult mouse spinal cord. (2001)

The slow immune response in the adult mammalian CNS results in slow myelin phagocytosis along degenerating white matter after injury. This has important consequences for axon regeneration because of the presence of axon growth inhibitors in myelin. In addition, abnormal immune cell responses in the CNS lead to demyelinating disease. Lysophosphatidylcholine (LPC) can induce an inflammatory response in the CNS, producing rapid demyelination without much damage to adjacent cells. In this study, we searched for the molecular switches that turn on this immune cell response. Using reverse transcription PCR analysis, we show that mRNA expression of macrophage inflammatory protein-1alpha (MIP-1alpha), macrophage chemotactic protein-1 (MCP-1), granulocyte macrophage-colony stimulating factor (GM-CSF), and tumor necrosis factor-alpha (TNF-alpha) in the spinal cord is rapidly and transiently upregulated after intraspinal injection of LPC. Neutralizing these signaling molecules with function-blocking antibodies suppresses recruitment of T-cells, neutrophils, and monocytes into the spinal cord, as well as significantly reduces the number of phagocytic macrophages and the demyelination induced by LPC. These findings will have important implications for CNS regeneration and demyelinating disease.
Estimation of compressed breast thickness during mammography. (1998)

To estimate radiation dose during mammography the breast thickness must be known. We present a new method for estimating the thickness of a compressed breast using only the breast image as projected onto a mammogram, calibration data such as the mAs value and image processing techniques. The method proves to be of high accuracy (+/- 0.2 cm for craniocaudal mammograms) and has the advantage over other methods of allowing retrospective estimation of thickness.
Study of Physico-Chemical Characteristics of Wastewater in an Urban Agglomeration in Romania (2012)

This study investigates the level of wastewater pollution by analyzing its chemical characteristics at five wastewater collectors. Samples are collected before they discharge into the Danube during a monitoring campaign of two weeks. Organic and inorganic compounds, heavy metals, and biogenic compounds have been analyzed using potentiometric and spectrophotometric methods. Experimental results show that the quality of wastewater varies from site to site and it greatly depends on the origin of the wastewater. Correlation analysis was used in order to identify possible relationships between concentrations of various analyzed parameters, which could be used in selecting the appropriate method for wastewater treatment to be implemented at wastewater plants.
Force-position-velocity control with self-tuning for robotic manipulators (1986)

The force-path control of a robotic manipulator is presented here in the joint and in the Cartesian coordinate systems. An autoregressive model with external excitation (ARX-model) is introduced for designing an adaptive controller with self-tuning. The controller minimizes the conditional expectation of the sum of a quadratic position (velocity) error and a quadratic force error while satisfying the constraint of the ARX-model with the estimates substituted for the unknown parameters. The basic approach is used to obtain an adaptive controller which operates on the variables expressed in the joint coordinates. Another adaptive controller is similarly determined for the system variables of the Cartesian coordinate system. The adaptive controller for force-path control introduced here has the form similar to that of hybrid force/position controller of [5], but with time varying gains.
A quantum-chemical perspective into low optical-gap polymers for highly-efficient organic solar cells (2011)

The recent and rapid enhancement in power conversion efficiencies of organic-based, bulk-heterojunction solar cells has been a consequence of both improved materials design and better understanding of the underlying physical processes involved in photocurrent generation. In this Perspective, we first present an overview of the application of quantum-chemical techniques to study the intrinsic material properties and molecular- and nano-scale processes involved in device operation. In the second part, these quantum-chemical tools are applied to an oligomer-based study on a collection of donor–acceptor copolymers that have been used in the highest-efficiency solar cell devices reported to date. The quantum-chemical results are found to be in good agreement with the empirical data related to the electronic and optical properties. In particular, they provide insight into the natures of the electronic excitations responsible for the near-infrared/visible absorption profiles, as well as into the energetics of the low-lying singlet and triplet states. These results lead to a better understanding of the inherent differences among the materials, and highlight the usefulness of quantum chemistry as an instrument for material design. Importantly, the results also point to the need to continue the development of integrated, multiscale modeling approaches to provide a thorough understanding of the materials properties.
2004 Annual Index IEEE Computer Graphics and Applications Vol. 24 (2004)

This index covers all technical items - papers, correspondence, reviews, etc. - that appeared in this periodical during the year, and items from previous years that were commented upon or corrected in this year. Departments and other items may also be covered if they have been judged to have archival value. The Author Index contains the primary entry for each item, listed under the first author's name. The primary entry includes the coauthors' names, the title of the paper or other item, and its location, specified by the publication abbreviation, year, month, and inclusive pagination. The Subject Index contains entries describing the item under all appropriate subject headings, plus the first author's name, the publication abbreviation, month, and year, and inclusive pages. Note that the item title is found only under he primary entry in the Author Index.
Porcine endogenous retrovirus – advances, issues and solutions (2002)

No abstract.
A prospective comparison of echocardiography and device algorithms for atrioventricular and interventricular interval optimization in cardiac resynchronization therapy (2009)

There is a poor agreement in optimal AV and VV intervals determined by echocardiography and QuickOpt, with echocardiographic optimization giving a superior haemodynamic outcome.
Cross-layer design: a survey and the road ahead (2005)

Of late, there has been an avalanche of cross-layer design proposals for wireless networks. A number of researchers have looked at specific aspects of network performance and, approaching cross-layer design via their interpretation of what it implies, have presented several cross-layer design proposals. These proposals involve different layers of the protocol stack, and address both cellular and ad hoc networks. There has also been work relating to the implementation of cross-layer interactions. It is high time that these various individual efforts be put into perspective and a more holistic view be taken. In this article, we take a step in that direction by presenting a survey of the literature in the area of cross-layer design, and by taking stock of the ongoing work. We suggest a definition for cross-layer design, discuss the basic types of cross-layer design with examples drawn from the literature, and categorize the initial proposals on how cross-layer interactions may be implemented. We then highlight some open challenges and new opportunities for cross-layer design. Designers presenting cross-layer design proposals can start addressing these as they move ahead.
Extraction of Chlorpyrifos and Malathion from Water by Metal Nanoparticles (2007)

The nanoparticles of gold and silver in solution state and supported over activated alumina are effective systems for the quantitative removal of chlorpyrifos and malathion, two common pesticides found in surface waters of developing nations, from water. In the solution phase, these pesticides adsorb onto the nanoparticles' surfaces and upon interaction for a long time, the nanoparticles with adsorbed pesticides precipitate. In contrast, complete removal of these pesticides occurs when contaminated water is passed over nanoparticles supported on alumina. A prototype of an on-line filter was made using a column of activated alumina powder loaded with silver nanoparticles and the device was used for pesticide removal for extended periods. We believe that the method has great technological potential in drinking water purification, especially using silver nanoparticles.
Sources Wanted (1948)

Journal Article Sources Wanted Get access A. H. Wheeler A. H. Wheeler Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume 193, Issue 9, 1 May 1948, Page 194, https://doi.org/10.1093/nq/193.9.194c Published: 01 May 1948
Web traffic demand forecasting using wavelet‐based multiscale decomposition (2001)

In this paper we propose an experimental forecasting strategy taking into account the long-range dependence of aggregate network traffic, and we apply it to provide one-minute-ahead World-Wide Web (Web) traffic demand forecasts in terms of average number of bytes transferred. Recently, statistical examination of Web traces have shown evidence that Web traffic arising from file transfers exhibits a behavior that is consistent with the notion of self-similarity. Essentially, self-similarity indicates that significant burstiness is present on a wide range of time scales (i.e., the process is long-range dependent). Hence the idea of exploiting this multiscale property with a view towards discovering and capturing regularities underlying the time series which may prove useful for short-term traffic load forecasting. We carry out a wavelet transform decomposition of the original series to decompose the traffic time series into varying scales of temporal resolution, with the aim of making the underlying temporal structures more tractable. In a second step, each individual wavelet series—supposed to capture some features of the series—is fitted with a dynamical recurrent neural network (DRNN) model to output the wavelet forecast. The latter are afterwards recombined to form the next-minute Web Traffic demand. The method is applied on a large set of HTTP logs and is shown to yield good results. © 2001 John Wiley & Sons, Inc.
Periodic unit cell reconstruction of porous media: Application to open-cell aluminum foams (2007)

In this article, the issue of reconstructing an idealized periodic unit cell (PUC) to represent a porous medium is examined by means of microcomputed tomography (μCT). Using μCT, three-dimensional images of open-cell foam are collected and used to characterize the representative parameters of its cellular morphology. These parameters are used in order to reconstruct the porous medium by means of an idealized PUC: a tetrakaidecahedron with ligaments of triangular cross sections, whose characteristic dimensions have been measured on the μCT images. The proposed reconstruction of the idealized PUC is applied to four aluminum foams. The averaged macroscopic properties of the foams (open porosity and thermal characteristic length) are deduced from their respective PUC model and compared to experimental measurements and literature data. Good correlations are obtained. For each of the foams, this provides a parameterized idealized periodic unit cell on which the partial differential equations governing sound dissipation and propagation in foams can be solved with a view to studying the microphysical basis of the acoustical macrobehavior.
Advancement of Imidazo[1,2-<i>a</i>]pyridines with Improved Pharmacokinetics and nM Activity vs. <i>Mycobacterium tuberculosis</i> (2013)

A set of fourteen imidazo[1,2-<i>a</i>]pyridine-3-carboxamides was synthesized and screened against <i>Mycobacterium tuberculosis</i> H<sub>37</sub>Rv. The minimum inhibitory concentrations of twelve of these agents were ≤ 1 μM against replicating bacteria and five compounds (<b>9, 12, 16, 17</b> and <b>18</b>) had MIC values ≤ 0.006 μM. Compounds <b>13</b> and <b>18</b> were screened against a panel of MDR and XDR drug resistant clinical <i>Mtb</i> strains with the potency of <b>18</b> surpassing that of clinical candidate PA-824 by nearly 10 fold. The <i>in vivo</i> pharmacokinetics of compounds <b>13</b> and <b>18</b> were evaluated in male mice by oral (PO) and intravenous (IV) routes. These results indicate that readily synthesized imidazo[1,2-<i>a</i>]pyridine-3-carboxamides are an exciting new class of potent, selective anti-TB agents that merit additional development opportunities.
Lipid production from Jerusalem artichoke by Rhodosporidium toruloides Y4 (2010)

Jerusalem artichoke (JA) is a perennial herbaceous plant widely available as non-grain raw material. Microbial lipid has been suggested as a potential feedstock for large scale biodiesel production. This paper describes lipid production using JA tuber processed by oleaginous yeast Rhodosporidium toruloides Y4. Batch and fed-batch modes were tested with feeding of concentrated JA extracts or JA hydrolysates. Cultivation of R. toruloides Y4 with JA extracts gave a moderate cellular lipid content of 40% (w/w), whereas lipid titer and cellular lipid content reached 39.6 g l(-1) and 56.5% (w/w), respectively, when JA hydrolysates were fed. Our results suggested that JA tubers may be further explored as raw material for large scale microbial lipid production.
Immunomodulatory Agents from Plants (1999)

The human immune system, despite having its own sophisticated defence mecha nisms, is inferior to bacteria and viruses with respect to adaptability. Furthermore, our immune system is increasingly expo
Data Processing on a Unimolecular Platform (2010)

En route to bits and bytes: The integration of complex logic functions within individual molecules allows data processing at the molecular level, as demonstrated by recently reported molecular encoder and decoder devices. This research on decision-making molecules has great potential for future applications and more complex computing on a functional unimolecular platform.
Expert system for team facilitation using observational learning (2007)

While ABET criteria require that engineering graduates be able to “function on multidisciplinary teams” and “communicate effectively”, the need for effective team skills goes far deeper. One solution is the use of a computationally intelligent “virtual facilitator” that contains a subset of the expert knowledge of a skilled facilitator. The “virtual facilitator” models behaviors of an expert facilitator to engineering student teams as they are working together. Albert Bandura’s theory of observational learning suggests that skills can be developed through observation of expert “others” engaged in practice. Preliminary research indicates that students can increase beneficial team behaviors (such as inquiry) through observation and imitation of an expert system. This paper is an extension of a 2005 FIE Work-In-Progress presentation that documented an expert facilitator system. In this study the system is used as part of an hour-long team exercise for engineering students. This study looks at student interactions during the exercise. Measures include analysis of team conversations for instances of imitation of the expert system, as well as a comparison of differences in team performance. The potential for an easily disseminated method to help engineering students learn effective team skills is discussed.
Isolation of chicken immunoglobulins (IgY) from egg yolk* (2003)

Abstract Separating individual proteins from complex mixtures of molecules is the basis of many biochemical investigations. The method describes the separation of immunoglobulin Y (IgY) from chicken eggs using a series of physical and chemical separation techniques. The separation is rapid, and the success of each step is readily viewed on an SDS‐polyacrylamide gel. IgY identity can be confirmed on a Western blot probed with enzyme‐labeled anti‐IgY antibodies. The method is a good illustration of protein separation when there is no enzyme activity to follow.
Central Pattern Generators for Locomotion, with Special Reference to Vertebrates (1985)

There is a gap to be bridged in vertebrate neurobiology, a gap between our knowledge of cellular mechanisms and behavior. We have achieved a widely expanded knowledge of how individual neurons function, and about synaptic transmission and membrane channels. We also increasingly understand the overall organization of different patterns of behavior, which principles apply, and which parts of eNS are important. We know much about how cells in the visual cortex respond, but little about how we perceive visual images; we know much about neuronal activity in motor cortex in relation to hand move­ ments, but little about how they are actually generated. One great challenge is to bridge this gap to understand how individual eNS neurons interact to generate different patterns of behavior, or make us perceive the environment, or memorize what we experience. Invertebrate neurobiologists have had considerable success in describing somc vcry important aspects of the cellular bases of behavior, such as asso­ ciative learning in molluscs (Kandel & Schwartz 1982) and basic patterns of behavior (Getting 1983a, Bullock 1982). In this chapter we deal with one limited aspect: how the central pattern generators that control locomotion function. Although the review is general, it emphasizes the vertebrates. We try to outline not only what we know, but also what directions seem most promising for gaining insight into how the eNS controls behavior. 233
Fourier Transform Raman Spectroscopy of Honey (2002)

In this work we present the Fourier transform Raman spectra of several commercial samples of honey in different states, comprising nine crystallized and three fluid samples. The measured water content of the specimens bears no relationship to their fluid behavior. The relative intensities of the vibrational bands in the C–H stretching region of the FT-Raman spectra are found to be sensitive to the observed physical states of the specimens. Several observed vibrational bands in the region 500–1800 cm −1 could be identified as fingerprints of the two major components in honey, fructose, and glucose, and at least one vibrational band was characteristic of sucrose. A relationship between the bandshape of the C–H stretching bands of honey specimens and their fluid properties was noted; crystallized samples show a well-resolved distinctive spectrum in this region, whereas the fluid samples do not exhibit this pattern. Some minor differences in the FT-Raman spectra of the honey specimens are discussed in terms of composition (saccharides and water) and the fluid state of the samples.
An Effector-Reduced Anti- -Amyloid (A ) Antibody with Unique A  Binding Properties Promotes Neuroprotection and Glial Engulfment of A  (2012)

Passive immunization against β-amyloid (Aβ) has become an increasingly desirable strategy as a therapeutic treatment for Alzheimer's disease (AD). However, traditional passive immunization approaches carry the risk of Fcγ receptor-mediated overactivation of microglial cells, which may contribute to an inappropriate proinflammatory response leading to vasogenic edema and cerebral microhemorrhage. Here, we describe the generation of a humanized anti-Aβ monoclonal antibody of an IgG4 isotype, known as MABT5102A (MABT). An IgG4 subclass was selected to reduce the risk of Fcγ receptor-mediated overactivation of microglia. MABT bound with high affinity to multiple forms of Aβ, protected against Aβ1-42 oligomer-induced cytotoxicity, and increased uptake of neurotoxic Aβ oligomers by microglia. Furthermore, MABT-mediated amyloid plaque removal was demonstrated using in vivo live imaging in hAPP((V717I))/PS1 transgenic mice. When compared with a human IgG1 wild-type subclass, containing the same antigen-binding variable domains and with equal binding to Aβ, MABT showed reduced activation of stress-activated p38MAPK (p38 mitogen-activated protein kinase) in microglia and induced less release of the proinflammatory cytokine TNFα. We propose that a humanized IgG4 anti-Aβ antibody that takes advantage of a unique Aβ binding profile, while also possessing reduced effector function, may provide a safer therapeutic alternative for passive immunotherapy for AD. Data from a phase I clinical trial testing MABT is consistent with this hypothesis, showing no signs of vasogenic edema, even in ApoE4 carriers.
A Sub-Pixel Correspondence Search Technique for Computer Vision Applications (2004)

SUMMARY This paper presents a technique for high-accuracy correspondence search between two images using Phase-Only Correlation (POC) and its performance evaluation in a 3D measurement application. The proposed technique employs (i) a coarse-to-fine strategy using image pyramids for correspondence search and (ii) a sub-pixel window alignment technique for finding a pair of corresponding points with sub-pixel displacement accuracy. Experimental evaluation shows that the proposed method makes possible to estimate the displacement between corresponding points with approximately 0.05-pixel accuracy when using 11 × 11pixel matching windows. This paper also describes an application of the proposed technique to passive 3D measurement system.
Symmetric Adiabatic Logic Circuits against Differential Power Analysis (2010)

We investigate the possibility of using adiabatic logic as a countermeasure against differential power analysis (DPA) style attacks to make use of its energy efficiency. Like other dual-rail logics, adiabatic logic exhibits a current dependence on input data, which makes the system vulnerable to DPA. To resolve this issue, we propose a symmetric adiabatic logic in which the discharge paths are symmetric for data-independent parasitic capacitance, and the charges are shared between the output nodes and between the internal nodes, respective v to prevent the circuit from depending on the previous input data.