gebhart/patrepeval huggingface dataset:
A Cooperative Information Storage and Retrieval System for the Petroleum Industry (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Cooperative Information Storage and Retrieval System for the Petroleum IndustrySamuel J. MartinezCite this: J. Chem. Doc. 1973, 13, 2, 59–65Publication Date (Print):May 1, 1973Publication History Published online1 May 2002Published inissue 1 May 1973https://pubs.acs.org/doi/10.1021/c160049a006https://doi.org/10.1021/c160049a006research-articleACS PublicationsRequest reuse permissionsArticle Views33Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
The structure of the diterpenoid baccatin-I, the 4β,20-epoxide of 2α,5α,7β,9α,10β,13α-hexa-acetoxytaxa-4(20),11-diene (1970)

Baccatin-I has been shown to be the 4β,20-epoxide of 2α,5α,7β,9α,10β,13α-hexa-acetoxytaxa-4(20),-11-diene (I), and 5α-deacetylbaccatin-I (III) and 1β-hydroxybaccatin-I (IV) have also been isolated.
Computer Simulation of Biomolecular Systems: Theoretical and Experimental Applications (1989)

third volume in the series on Computer Simulation of Biomolecular Systems continues with the format introduced in the first volume [1] and elaborated in the second volume [2]. primary emphasis is on the methodological aspects of simulations, although there are some chapters that present the results obtained for specific systems of biological focus of this volume has changed somewhat since there are several chapters devoted to structure-based ligand design, which had only a single chapter in the second volume. It seems useful to set the stage for this volume by quoting from my preface to Volume 2 [2]. The long-range 'goal of molecular approaches to biology is to describe living systems in terms of chemistry and physics. Over the last fifty years great progress has been made in applying the equations representing the underlying physical laws to chemical problems involv- ing the structures and reactions of small molecules. Corresponding studies of mesoscopic systems have been undertaken much more recently. Molecular dynamics simulations, which are the primary focus of this volume, represent the most important theoretical approach to macromolecules of biological interest. ...
Bridging fault analysis in digital circuits. (1974)

Massachusetts Institute of Technology. Dept. of Electrical Engineering. Thesis. 1974. M.S.
SmartFingerBraille: A tactile sensing and actuation based communication glove for deafblind people (2017)

This paper presents a smart tactile sensing and actuation-based finger-glove to be used by visual and hearing impaired people for communication and learning. It is based on the concept of finger Braille and supports both face-to-face and distant communication. The device comprises of a smart finger-glove worn on both hands in the ring, middle and index finger and communicates with mobile devices using Bluetooth technology. Six tactile sensors and actuators each were used and a pair embedded in the glove in the ring, middle, and index fingers of both hands to represent the six dots of the Braille code. The user wears the smart finger-glove and taps the correct finger combination corresponding to the Braille code on any surface to compose and send messages to mobile devices or other gloves. Messages can equally be received with the glove from a mobile device in the form of vibrations on the fingers corresponding to the Braille codes. The facile and low-cost nature of the device will make it attractive to Braille users and makes learning Braille an entertainment activity and could spur the interest of sighted people also to learn Braille.
<i>Mycobacterium paratuberculosis</i> Monoassociated Nude Mice as a Paratuberculosis Model (1991)

In this study, a paratuberculosis (Johne's disease) model was developed by intragastrically dosing gnotobiotic athymic nude mice with Mycobacterium paratuberculosis. The mice infrequently shed bacilli from their intestinal tracts during the first 4 months after inoculation. Following this time, increasing numbers of M. paratuberculosis (greater than 4.0 log10 bacilli per fecal pellet by 40 weeks) were recovered from the feces of the 12 mice that remained in the isolator. A similar pattern of recovery of M. paratuberculosis was obtained from the ileum, cecum, colon, and liver. Histopathologic lesions and acid-fast bacilli were rare during the first 4 months of infection and then, with time, increased in prevalence and severity. Mice maintained for 7 months or longer exhibited severe granulomatous inflammation and large numbers of acid-fast bacilli in the gastrointestinal tract and liver (up to 10(8) log10 colony forming units per gram wet weight). Five mice maintained for 7 months or more developed clinical signs consistent with those seen in paratuberculosis (weight loss, chronic diarrhea); three of these mice eventually died or became moribund and were euthanatized. M. paratuberculosis monoassociated mice released increased levels of tumor necrosis factor activity into their sera, as compared to uninfected control mice, when they were injected with bacterial lipopolysaccharide. The clinical signs, fecal shedding of M. paratuberculosis, granuloma formation, and progressive bacillary multiplication observed with these mice are consistent with naturally occurring M. paratuberculosis infection of ruminants (Johne's disease). This model will be useful for future studies of immunoregulation and antimicrobial therapy of paratuberculosis.
Expression, topography, and function of integrin receptors are severely altered in keratinocytes from involved and uninvolved psoriatic skin. (1992)

Psoriasis is a hyperproliferative cutaneous disease of unknown etiology and etiopathogenesis. Alteration of keratinocyte adhesiveness to basal lamina has been proposed as the initial disturbance leading to poorly controlled proliferation. Keratinocyte adhesion to basal lamina and lateral interactions among basal epidermal cells are mediated, besides other molecules, by integrin receptors that are segregated to discrete membrane domains. In this paper, the expression and function of integrins in psoriatic keratinocytes were examined, both in vivo and in vitro. We found that: (a) in psoriatic keratinocytes the integrin heterodimers alpha 2 beta 1, alpha 3 beta 1, and alpha 6 beta 4 have lost their polarized distribution on the plasma membrane; (b) the role of these integrins in mediating keratinocyte adhesion in vitro is altered; (c) psoriatic keratinocytes form focal contacts containing both beta 1 and beta 4 integrins. In normal adult keratinocytes the alpha 5 beta 1 fibronectin receptor is poorly expressed and diffusely distributed on the basal keratinocyte plasma membrane and is not organized in defined adhesive structures. In contrast, psoriatic keratinocytes show a clear fibronectin receptor staining in vivo, and organize alpha 5 beta 1 in typical focal contacts in vitro without any obvious increase of its expression and synthesis. These multiple alterations of integrins are also present in uninvolved keratinocytes from psoriatic patients, suggesting a key role for altered integrin-mediated adhesion in the pathogenesis of this disease.
Medical and nursing problems of children with neurodegenerative disease (1995)

Little is written on the management of problems encountered by children with neurodegenerative disease. Whilst the conditions are individually rare, as a group of diseases they pose a considerable burden on the child, the family and the community. This study describes the 127 children with neurodegenerative disease who were admitted to Helen House, a hospice for children, from the time of opening in November 1982 until the end of 1993. The great majority of the conditions were genetic in origin and nearly one-third of the families had had two or more children with the same disease. Seventy-four (58%) of the children have died, with nearly half dying at home. The course of the disease was in many cases chronic and these children presented with multiple medical and nursing problems. Examination of the problems recorded in 1993 revealed that nearly all the children had no speech, or speech was impaired. Most were either totally immobile or had considerably reduced mobility. Seventy per cent of the children had feeding problems and one-quarter were fed through a nasogastric tube or gastrostomy. Thirty-five per cent of the children suffered pain on occasions, with muscle spasm being the main identifiable source of pain. Practical suggestions are made for the management of these children.
Glycogen phosphorylase BB in acute coronary syndromes (2005)

The diagnosis of myocardial damage is preferably based on measurement of the cardiac-specific troponins. However, there is an emerging need for early, specific cardiac markers. One potential candidate is the glycogen phosphorylase BB isoenzyme (GPBB). We investigated the use of a new, commercially available GPBB ELISA assay in 61 patients presenting with an acute coronary syndrome (37 acute myocardial infarction, 24 unstable angina pectoris) in comparison to established cardiac markers such as troponin T, creatine kinase isoenzyme MB (CKMB) mass, and myoglobin. Blood samples were obtained on arrival, as well as 1, 2, 3, 4, 8, 12 and 24 h later. GPBB plasma concentrations were elevated in 90.9% of patients 1 h after onset of chest pain and increased to 100% at 4-5 h. Within the first 6 h, GPBB showed the highest sensitivity (95.5-100%) and high specificity (94-96%) compared to myoglobin (85-95% sensitivity) and CKMB mass (71.4-91.3% sensitivity). As expected, troponin T showed high specificity (100%) and sensitivity >95% later in the time course (>or=3 h). In un-stable angina pectoris patients, a very high rate of elevated GPBB was observed (93.9% at 3 h) compared to myoglobin (66.7%). Cardiac troponin T and CKMB were only elevated in 33.8% and 55.0% of these patients, respectively. In conclusion, GPBB is a promising marker for the early diagnosis of acute coronary syndromes and could probably act as a marker of ischemia. However, further studies on specificity and development of a fast, automated assay are necessary before GPBB can be recommended as a routine diagnostic tool.
Cognitive Neuroscience: The Biology of the Mind (1998)

Three leading figures in the field of cognitive neuroscience provide an engaging, narrative-driven overview of this path-breaking field. Taking a highly interdisciplinary approach, the authors balance cognitive theory, with neuroscientific and neuropsychological evidence to reveal what we currently know about how the human mind works and to encourage students to think like cognitive neuroscientists. The text has been reorganised to move more seamlessly from micro to macro level topics, and its underlying pedagogy strengthened in order to make it an even more effective teaching tool. (Presentation editeur)
Bridging Institutional Voids through New Services: Case Studies and Analysis (2012)

Firms operating in emerging markets face high transaction costs due to the absence of well-functioning market intermediaries. These, referred to as institutional voids, have to be overcome for buyers and sellers to come together and transact efficiently. In this paper, we examine how six IT based service innovations have helped bridge institutional voids in talent, capital and product markets. We begin with an analysis of these new service offerings and describe how they helped bridge institutional voids. We later analyze the case studies on three dimensions - source of innovation and role of technology, acquiring resources and capabilities for innovation, and scaling of the services.
Natronococcus amylolyticus sp. nov., a Haloalkaliphilic Archaeon (1995)

The alpha-amylase-producing haloalkaliphilic archaeon Natronococcus sp. strain Ah-36T (T = type strain) was isolated previously from a Kenyan soda lake, Lake Magadi. Most cells of strain Ah-36T occurred in irregular clusters, and the colonies were orange-red. The polar lipids of this organism were composed of C20, C20 and C20, C25 derivatives of phosphatidylglycerol and phosphatidylglycerophosphate. Phosphatidylglycero-(cyclo-) phosphate, which is characteristic of Natronococcus occultus, was not detected. The complete nucleotide sequence of the 16S rRNA gene revealed that the closest relative of strain Ah-36T is N. occultus ATCC43101T (level of similarity, 96.4%), an extremely halophilic archaeon. However, strain Ah-36T did not exhibit a significant level of DNA homology to N. occultus ATCC43101T, which represents the only previously described species in the genus Natronococcus. We describe a new species for strain Ah-36T, for which we propose the name Natronococcus amylolyticus.
Development of a Self-Contained, PV-Powered Domestic Toilet and Wastewater Treatment System (2013)

Abstract not Available.
A Comparative Analysis of Computer-Suported Learning Models and Guidelines (2007)

This chapter presents a comprehensive analytical review of computer-supported learning (CSL) design models and guidelines according to the level of emphasis regarding key elements and dimensions of effective teaching and learning within an online environment. The key elements encompass learning activities, learning environment, and/or assessment of student learning. Ultimately our purpose was to identify components that experts considered as critical to achieving effective CSL environments in order to use this information as a framework to design, develop, and implement CSL. The results indicate that the trend in CSL design and development models and guidelines is to create online environments that support constructivist learning that is student-centered, presents resources in varied formats, supports discussions and/or collaborative and/or problem-based learning as well as independent student research and use of resources.
Thermal degradation of microbial copolyesters: poly(3-hydroxybutyrate-co-3-hydroxyvalerate) and poly(3-hydroxybutyrate-co-4-hydroxybutyrate) (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThermal degradation of microbial copolyesters: poly(3-hydroxybutyrate-co-3-hydroxyvalerate) and poly(3-hydroxybutyrate-co-4-hydroxybutyrate)Masao Kunioka and Yoshiharu DoiCite this: Macromolecules 1990, 23, 7, 1933–1936Publication Date (Print):April 1, 1990Publication History Published online1 May 2002Published inissue 1 April 1990https://pubs.acs.org/doi/10.1021/ma00209a009https://doi.org/10.1021/ma00209a009research-articleACS PublicationsRequest reuse permissionsArticle Views1006Altmetric-Citations226LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Nck-2, a Novel Src Homology2/3-containing Adaptor Protein That Interacts with the LIM-only Protein PINCH and Components of Growth Factor Receptor Kinase-signaling Pathways (1998)

Many of the protein-protein interactions that are essential for eukaryotic intracellular signal transduction are mediated by protein binding modules including SH2, SH3, and LIM domains. Nck is a SH3- and SH2-containing adaptor protein implicated in coordinating various signaling pathways, including those of growth factor receptors and cell adhesion receptors. We report here the identification, cloning, and characterization of a widely expressed, Nck-related adaptor protein termed Nck-2. Nck-2 comprises primarily three N-terminal SH3 domains and one C-terminal SH2 domain. We show that Nck-2 interacts with PINCH, a LIM-only protein implicated in integrin-linked kinase signaling. The PINCH-Nck-2 interaction is mediated by the fourth LIM domain of PINCH and the third SH3 domain of Nck-2. Furthermore, we show that Nck-2 is capable of recognizing several key components of growth factor receptor kinase-signaling pathways including EGF receptors, PDGF receptor-beta, and IRS-1. The association of Nck-2 with EGF receptors was regulated by EGF stimulation and involved largely the SH2 domain of Nck-2, although the SH3 domains of Nck-2 also contributed to the complex formation. The association of Nck-2 with PDGF receptor-beta was dependent on PDGF activation and was mediated solely by the SH2 domain of Nck-2. Additionally, we have detected a stable association between Nck-2 and IRS-1 that was mediated primarily via the second and third SH3 domain of Nck-2. Thus, Nck-2 associates with PINCH and components of different growth factor receptor-signaling pathways via distinct mechanisms. Finally, we provide evidence indicating that a fraction of the Nck-2 and/or Nck-1 proteins are associated with the cytoskeleton. These results identify a novel Nck-related SH2- and SH3-domain-containing protein and suggest that it may function as an adaptor protein connecting the growth factor receptor-signaling pathways with the integrin-signaling pathways.
High-precision interconnect analysis (1998)

Integrated circuits have evolved to a stage where interconnections significantly limit their performance and functional complexity. We introduce a set of tools to perform highly accurate three-dimensional capacitance and resistance/thermal calculations of interconnect structures. We automatically generate these structures from layout information and a given process description. The main enhancement of our work is that we extract the interconnect characteristics after a complete and accurate topography simulation with previous optional lithography analysis, instead of elementary geometric blocks derived from simple analytical models. The capacitance and resistance/thermal extractor simulators are based on optimized finite-element methods, and the topography simulators use a cellular data-based approach.
Status of Risk Factors for Vascular Dementia (1998)

The two most common causes of vascular dementia (VAD) are dementia evolving in connection with multiple small or large strokes and dementia related to ischemic white-matter lesions (WMLs) of the brain. The knowledge about risk factors for these disorders is still scarce. Besides sharing risk factors with stroke, dementia with multiple small or large brain infarcts is also associated with non-vascular risk factors such as high alcohol consumption, psychological stress in early life, lower formal education, blue collar occupation, and occupational exposures. Risk factors for dementia in stroke victims include stroke-related and non-stroke related risk factors. Non-stroke-related factors are similar to those found in Alzheimer's disease. The main risk factors for ischemic WMLs are hypertension or increased blood pressure, but WMLs have also been associated with a number of other vascular risk factors. In recent years, Alzheimer's disease (AD) has also been reported to be associated with vascular risk factors, including hypertension, coronary heart disease, atrial fibrillation, diabetes mellitus, and WMLs. Although these associations may reflect an overdiagnosis of AD in cases with silent cerebrovascular disease, or that cerebrovascular disease increases the possibility that individuals with Alzheimer lesions will express a dementia syndrome, there are also alternative explanations. AD and cerebrovascular disease may for instance share similar risk factors or etiologic pathways. The pathogenetic implications for the association between AD and vascular factors need to be further explored. There is also a need for more studies on risk factors for VAD and risk factors for dementia in stroke samples, as well as studies on non-vascular risk factors for ischemic WMLs.
System software and hardware support considerations for digital video and audio computing (2002)

Digital video and audio (DVA) input/output presents special problems to a computer system's underlying support software and hardware. The author explores what generic functionality the I/O bus, device controllers, and system software should provide to adequately support DVA applications executing on modern workstations connected by fast local area networks. The problems are due to the high data rates and timing constraints of DVA. To address these problems, more efficient data movement (minimizing data copying wherever possible) and better control over low-level timing of I/O transfers are required. System software must take better advantage of I/O bus functionality such as burst-mode transfers and peer-to-peer communication. While complex embedded systems are discouraged, controllers may be equipped with special-purpose functionality which causes a reduction in data movement, such as compression/decompression hardware. System I/O software should support separation of data transfer and I/O control.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Oligophosphaalkane, II. Tetra‐ und pentakoordinierte Komplexe α,ω‐PH‐funktioneller Triphosphaalkane H<sub>2–n</sub>R<sub>n</sub>P–[CH<sub>2</sub>]<sub>3</sub>–PR′–[CH<sub>2</sub>]<sub>3</sub>–PR<sub>n</sub>H<sub>2–n</sub> (1981)

Abstract Die Titel‐Triphosphaalkane (n = 0–2; R, R′ = Me, Ph) (3a–d) wurden durch radikalische Addition primärer oder disekundärer Phosphane an die Allylgruppe der Ester R′P(O)(OiPr)CH 2 CHCH 2 und nachfolgende LiAlH 4 ‐Reduktion der dabei erhaltenen Produkte dargestellt. 3b (R = Me, R′ = Ph, n = 1) läßt sich durch Metalliergung mit Methyllithium und Umsetzung des erhaltenen Phosphidophosphans mit Methyliodid in guter Ausbeute in das permethylierte Derivat Me 2 P[CH 2 ] 3 PPh[CH 2 ] 3 PMe 2 ( 3e ) überführen. Die Liganden 3a–e bilden mit NiBr 2 3 H 2 O oder K 2 MCl 4 Komplexe MX 2 L (4–6) (M = Ni II , Pd II oder Pt II ; X = Cl, Br; L = 3a–e ), deren Konstitution durch Messung der elektrischen Leitfähigkeit, UV/VIS‐ und 31 PNMR‐Spektroskopie ermittelt wurde. Bei den Nickelkomplexen liegt ein lösungsmittelabhängiges Gleichgewicht zwischen pentakoordiniertem NiX 2 L und quadratisch planarem [NiXL] + vor. Im Falle des Pd‐Komplexes [PdCl 2 (3b) ] (5b) spielt sich in Methanol‐Lösung ein Isomerisierungsprozeß an den terminalen P‐Atomen ab, der wahrscheinlich auf einer reversiblen Abspaltung von HCl beruht.