gebhart/patrepeval huggingface dataset:
Total Synthesis of (±)-Batrachotoxinin A (1998)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTTotal Synthesis of (±)-Batrachotoxinin AMichio Kurosu, Lawrence R. Marcin, Timothy J. Grinsteiner, and Yoshito KishiView Author Information Department of Chemistry and Chemical Biology Harvard University, Cambridge, Massachusetts 02138 Cite this: J. Am. Chem. Soc. 1998, 120, 26, 6627–6628Publication Date (Web):June 18, 1998Publication History Received14 April 1998Published online18 June 1998Published inissue 1 July 1998https://pubs.acs.org/doi/10.1021/ja981258ghttps://doi.org/10.1021/ja981258grapid-communicationACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views9088Altmetric-Citations77LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Addition reactions,Chemical synthesis,Ketones,Molecular structure,Organic synthesis Get e-Alerts
Predicted Performance of Superconductor-Insulator-Superconductor Mixers with Inhomogeneous Distributed Junction Arrays (2000)

The mixing properties of a new type of distributed superconductor-insulator-superconductor (SIS) junction array, which consists of different dimensions of junctions and spacings between every two junctions, have been theoretically investigated using the quantum theory of mixing. A set of dimensions of junctions and spacings between every two junctions of the distributed junction array have been determined so as to minimize the reflection coefficient of an S-parameter, S 11 , at the input port in the array using microwave computer-aided design, assuming that each SIS junction is represented by a parallel combination of linear normal-state resistance and geometrical capacitance. When the array is composed of well optimized set of dimensions of junctions and spacings between every two junctions, it is demonstrated that excellent mixing properties are attained over a broad-band in spite of the low critical current density of an SIS junction. It is also found that the degradation of mixing properties, which is always observed at certain frequencies in a conventional array with the equal dimensions of junctions and spacings, can be considerably suppressed in the array with a well optimized set of dimensions and spacings of junctions.
Decreased Ferritin Levels in Brain in Parkinson's Disease (1990)

Ferritin levels were measured in postmortem brain tissue from patients dying with Parkinson's disease [treated with L-3,4-dihydroxyphenylalanine (L-DOPA)] and from control patients. Ferritin levels were decreased in the substantia nigra, caudate-putamen, globus pallidus, cerebral cortex, and cerebellum when compared with age-matched control tissues. However, in CSF from L-DOPA-treated patients and in serum from L-DOPA-treated and untreated parkinsonian patients, ferritin levels were normal. Previous studies have suggested an increased total iron content in substantia nigra of parkinsonian brain. The failure of substantia nigra ferritin formation to be stimulated by increased iron levels suggests some defect in iron handling in this critical brain region in Parkinson's disease. The reason for decreased ferritin levels throughout the parkinsonian brain is not clear but does not seem to reflect a general system deficit in ferritin.
Efficient Ligation of the <i>Schistosoma</i> Hammerhead Ribozyme (2007)

The hammerhead ribozyme from Schistosoma mansoni is the best characterized of the natural hammerhead ribozymes. Biophysical, biochemical, and structural studies have shown that the formation of the loop-loop tertiary interaction between stems I and II alters the global folding, cleavage kinetics, and conformation of the catalytic core of this hammerhead, leading to a ribozyme that is readily cleaved under physiological conditions. This study investigates the ligation kinetics and the internal equilibrium between cleavage and ligation for the Schistosoma hammerhead. Single turnover kinetic studies on a construct where the ribozyme cleaves and ligates substrate(s) in trans showed up to 23% ligation when starting from fully cleaved products. This was achieved by an approximately 2000-fold increase in the rate of ligation compared to a minimal hammerhead without the loop-loop tertiary interaction, yielding an internal equilibrium that ranges from 2 to 3 at physiological Mg2+ ion concentrations (0.1-1 mM). Thus, the natural Schistosoma hammerhead ribozyme is almost as efficient at ligation as it is at cleavage. The results here are consistent with a model where formation of the loop-loop tertiary interaction leads to a higher population of catalytically active molecules and where formation of this tertiary interaction has a much larger effect on the ligation than the cleavage activity of the Schistosoma hammerhead ribozyme.
Speech enhancement using a constrained iterative sinusoidal model (2001)

This paper presents a sinusoidal model based algorithm for enhancement of speech degraded by additive broad-band noise. In order to ensure speech-like characteristics observed in clean speech, smoothness constraints are imposed on the model parameters using a spectral envelope surface (SES) smoothing procedure. Algorithm evaluation is performed using speech signals degraded by additive white Gaussian noise. Distortion as measured by objective speech quality scores showed a 34%-41% reduction over a SNR range of 5-to-20 dB. Objective and subjective evaluations also show considerable improvement over traditional spectral subtraction and Wiener filtering based schemes. Finally, in a subjective AB preference test, where enhanced signals were coded with the G729 codec, the proposed scheme was preferred over the traditional enhancement schemes tested for SNRs in the range of 5 to 20 dB.
Terahertz-bandwidth characteristics of coplanar transmission lines on low permittivity substrates (1994)

Coplanar striplines and waveguides capable of supporting ultra-high-frequency pulses over many millimeters of propagation length have been fabricated on low-permittivity substrates, including a durable 1.4-/spl mu/m-thick membrane. These transmission lines were characterized using broadband pulses from a novel in situ optoelectronic test-signal generator together with an electro-optic probe tip and an optically-based sampling technique. Pulse-propagation characteristics for the coplanar lines on the low-permittivity substrates have been compared in both the time and frequency domains with the transmission behavior of lines on GaAs substrates. A semi-empirical model has also been used to simulate the experimental results with good agreement, helping to indicate the origin of the distortion mechanisms involved. In addition, for the coplanar waveguide structures, waveforms corresponding to the even and odd modes have been individually resolved in the time domain for lines fabricated on the GaAs and membrane substrates.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Low-resistance ohmic contacts to <i>p</i>-type GaN (1999)

Low-resistance ohmic contacts with high transparency to p-type GaN have been developed by oxidizing Ni/Au thin films. Compared to the metallic Ni/Au contacts, the oxidized Ni/Au contacts exhibited lower specific contact resistance and much improved transparency. The transparency was from 65% to 80% in the wavelength of 450–550 nm. A specific contact resistance below 1.0×10−4 Ω cm2 was obtained by oxidizing Ni(10 nm)/Au(5 nm) on p-type GaN. The mechanism of low-resistance ohmic contact could be related to the formation of NiO.
Adaptive synchronization framework for navigated hypermedia document presentation (2005)

Synchronization anomalies, or so-called out-of-sync problems, may occur in a composite multimedia document presentation especially when a presentation tool receives unexpected events that destroy intermedia relations in the document. This work proposes an adaptive synchronization framework (ASF) to solve this problem by adopting a resynchronization procedure. In contrast to the existing approaches focusing on temporal synchronization only, spatial and content relations for a more general presentation are also considered and incorporated into the proposed synchronization core. The experimental results show that the proposed framework can adapt a document to an unsupervised presentation environment and the performance is satisfactory (85%) under some synchronization-killer operations.
High-Speed Shift Registers Using One Core Per Bit (1956)

A three, and a two winding per core, high-speed, current driven, one core per bit shift register is presented together with an analysis of the basic circuit involved. An intermediate storage capacitor is used between successive logical elements. The charge and discharge of this capacitor are controlled in a positive manner by voltage blocking pulses. The undesired feedback of energy from one stage to earlier stages is thereby prevented, giving high efficiency of operation. The three winding per core register described is reversible and capable of operating in the megacycle range. The application of the basic shift register element to computer logic applications is described.
The mycelium-associated Streptomyces reticuli catalase-peroxidase, its gene and regulation by FurS (1999)

During early stages of growth, Streptomyces reticuli synthesizes a hyphae-associated, haem-containing enzyme which exhibits catalase and peroxidase activities with broad substrate specificity (CpeB). The purified dimeric enzyme (160 kDa) consists of two identical subunits. Using anti-CpeB antibodies and an expression- as well as a mini-library, the corresponding cpeB gene was identified and sequenced. It encodes a protein of 740 aa with a molecular mass of 81.3 kDa. The deduced protein shares the highest level of amino acid identity with KatG from Caulobacter crescentus and Mycobacterium tuberculosis, and PerA from Bacillus stearothermophilus. Streptomyces lividans transformants carrying cpeB and the upstream-located furS gene with its regulatory region on the bifunctional vector pWHM3 produced low or enhanced levels of CpeB in the presence or absence of Fe ions, respectively. An in-frame deletion of the major part of furS induces increased CpeB synthesis. The data imply that FurS regulates the transcription of cpeB. The deduced FurS protein is rich in histidine residues, contains a putative N-terminally situated helix-turn-helix motif and has a molecular mass of 15.1 kDa. It shares only 29% amino acid identity with the Escherichia coli ferric uptake regulator (Fur) protein, but about 64% with FurA deduced from the genomic sequences of several mycobacteria. The predicted secondary structures of FurS and FurA are highly similar and considerably divergent from those of the E. coli Fur. In contrast to some Gram-negative bacteria, within several mycobacteria an intact furA gene or a furA pseudogene is upstream of a catalase-peroxidase (katG) gene predicted to encode a functional or a non-functional (Mycobacterium leprae) enzyme. Thus the data obtained for Streptomyces reticuli are expected to serve as an additional model to elucidate the regulation of mycobacterial catalase-peroxidase genes.
Management of obstructive hydrocephalus in pregnant patient (2016)

<i>De novo</i> obstructive hydrocephalus is a rare event during pregnancy. There are only case reports presented in literature. We aimed to discuss the pathophysiological basis and management options with an exemplary case presentation and review of the current literature. A 28-year-old G2P1 patient presented to our clinic with headache, vomiting, and deteriorated vision at the 8<sup>th</sup> week of gestation. She had no history of central nervous system infection or trauma. A brain magnetic resonance imaging was obtained. There was hydrocephalus due to cerebral aqueduct stenosis (Evan's index of 58%). She was managed conservatively with bed rest and diuretics; however, she got no relief. A ventriculoperitoneal shunt was inserted at the 13<sup>th</sup> week of gestation. At the 38<sup>th</sup> week, she had cesarean section (C/S) due to previous history of C/S in the first pregnancy and present cord entanglement of the fetus. C/S was conducted under epidural anesthesia after conforming she had no increased intra cranial pressure findings. Delivery was uneventful with a healthy newborn. Obstructive hydrocephalus is a very rare complication during pregnancy. Hydrocephalus becomes obvious and necessitates treatment, before the third trimester of pregnancy. Timely diagnosis, especially differentiation from preeclampsia, is a life-saving step. If no complication happens during intervention for hydrocephalus, spontaneous vaginal delivery is a safe way of delivery for both mother's and newborn's well-being. C/S should be saved for obstetrical indications and can be conducted under epidural anesthesia if intracranial pressure is kept under control. Interdisciplinary approach of neurosurgeons and anesthesiologists is pivotal for delicate care of the patient and the baby.
Capitellocondylar total elbow replacement in rheumatoid arthritis. Long-term results. (1993)

We evaluated the long-term results of 202 capitellocondylar total elbow replacements that had been performed, from July 1974 through June 1987, in 172 patients. The duration of follow-up averaged sixty-nine months (range, twenty-four to 178 months). At the most recent follow-up examination, use of a 100-point rating score demonstrated an improvement from an average preoperative score of 26 points (range, 2 to 50 points) to an average postoperative score of 91 points (range, 45 to 100 points). The most improvement occurred in the categories of relief of pain, functional status, and range of motion in all planes except extension. The improvements in these categories and in the roentgenographic appearance that were seen in the early postoperative period did not deteriorate with time. The average preoperative arc of motion at the elbow ranged from -37 degrees of extension to 118 degrees of flexion. The average postoperative arc of motion at the elbow ranged from -30 degrees of extension to 135 degrees of flexion. Supination improved from 45 degrees preoperatively to 64 degrees postoperatively; pronation improved from 56 degrees preoperatively to 72 degrees postoperatively. The roentgenograms showed a radiolucent line adjacent to eight humeral and nineteen ulnar components; most of the lines were incomplete and one millimeter wide or less. Revision of the prosthesis was necessary in three elbows (1.5 per cent) because of loosening without infection, and in three additional elbows because of dislocation of the prosthesis. Complications included deep infection in three elbows (1.5 per cent); problems related to the wound in fifteen (7 per cent); permanent, partial sensory ulnar-nerve palsy in five (2.5 per cent); permanent, partial motor ulnar-nerve palsy in one (0.5 per cent); and dislocation in seven (3.5 per cent).
Interaction of pseudomonic acid A with <i>Escherichia coli</i> B isoleucyl-tRNA synthetase (1980)

Sodium pseudomonate was shown to be a powerful competitive inhibitor of Escherichia coli B isoleucyl-tRNA synthetase (Ile-tRNA synthetase). The antibiotic competitively inhibits (Ki 6 nM; cf. Km 6.3 microM), with respect top isoleucine, the formation of the enzyme . Ile approximately AMP complex as measured by the pyrophosphate-exchange reaction, and has no effect on the transfer of [14C]isoleucine from the enzyme . [14C]Ile approximately AMP complex to tRNAIle. The inhibitory constant for the pyrophosphate-exchange reaction was of the same order as that determined for the inhibition of the overall aminoacylation reaction (Ki 2.5 nM; cf. Km 11.1 microM). Sodium [9'-3H]pseudomonate forms a stable complex with Ile-tRNA synthetase. Gel-filtration and gel-electrophoresis studies showed that the antibiotic is only fully released from the complex by 5 M-urea treatment or boiling in 0.1% sodium dodecyl sulphate. The molar binding ratio of sodium [9'-3H]pseudomonate to Ile-tRNA synthetase was found to be 0.85:1 by equilibrium dialysis. Aminoacylation of yeast tRNAIle by rat liver Ile-tRNA synthetase was also competitively inhibited with respect to isoleucine, Ki 20 microM (cf. Km 5.4 microM). The Km values for the rat liver and E. coli B enzymes were of the same order, but the Ki for the rat liver enzyme was 8000 times the Ki for the E. coli B enzyme. This presumably explains the low toxicity of the antibiotic in mammals.
How Far Can I Trust You? The Impact of Distance and CulturalValues on Leaders’ Trustworthiness (2012)

Employees ’ level of trust in leaders has long been deemed an important key to successful organizational dynamics and performance. Utilizing survey data, the current study investigates differences in levels of trust between one’s immediate manager and the organization’s top leadership, the impact of individualism/collectivism on these levels of trust, and the influence of leader-follower distance on leadership trust. Results revealed higher levels of trust for direct leaders than organizational leaders among the U.S. sample. While individualism/collectivism was not found to significantly affect levels of leadership trust, perceptions of less leadership distance had a positive impact on levels of leadership trust.
A degradation analysis methodology for maintenance tasks (1985)

The modeling performance degradation due to chemical protective clothing has become an area of increasing interest to military analysts but has been plagued by a lack of reliable data. This research effort proposes a methodology for estimating the mechanical degradation of individual soldiers when wearing this clothing. With maintenance tasks as the investigative focal point, applicable areas of work measurement, human performance, maintenance management and degradation modeling were used to develop the Degradation Analysis Methodology for Maintenance (DAMM). Using a decision model and the appropriate Army technical manual, a taxonomy for maintenance task analysis divides individual repair jobs into task elements according to their aim and the manual manipulation required. A procedure for obtaining movement degradation values was developed and applied using field test data. The results were then incorporated into the Ballistic Research Laboratory degraded effectiveness algorithm. DAMM constitutes an improvement over the subjective degradation estimates which predominate in current data bases and does not require costly field testing.
Stability projections for high temperature superconductors (1989)

The stability of the high-temperature superconducting oxides has been analyzed, using the methodology developed for conventional type II superconductors. The results are presented in graphical form for the temperature range from 4 to 100 K. For a 90-K superconductor the first flux jump field peaks above 7 T at 60 K, and for a 120-K superconductor it peaks above 12 T at 75 K. The maximum adiabatically stable thickness increases greatly. The linear dimension of the minimum propagating zone increases by a factor of 3 to 5, and the quench propagation velocity drops by four orders of magnitude. It is concluded that the high-temperature superconducting materials will have much higher stability than conventional type II superconductors and that their high flux jump fields will make ultrafine multifilamentary conductors unnecessary and improve the outlook for tape conductors. The energy required to create a propagating zone is increased. However, methods of coil protection will have to be modified.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
ON THE MAXIMAL INEQUALITY FOR AANA RANDOM VARIABLES AND A STRONG LAW OF LARGE NUMBERS (2003)

In this paper we Obtain the Hajeck-Renyi type inequality for the asymptotically almost negatively associated(AANA) random variables and extend some results for negatively associated random variables to the AANA case by applying this inequality.
The single lamprey neurofilament subunit (NF-180) lacks multiphosphorylation repeats and is expressed selectively in projection neurons (1995)

The lamprey is considered the most primitive living vertebrate and its neurofilaments (NFs) are unique in being homopolymers of a single 180 kDa subunit (NF-180). Previous immunologic studies have suggested that the sidearm of NF-180 is highly phosphorylated selectively in the largest diameter axons. We report in this study the isolation and characterization of cDNA clones encoding the NF-180 lamprey protein. In situ hybridization with digoxigenin-labeled cRNA revealed NF-180 message exclusively in neurons with long axons, such as reticulospinal neurons and cranial motor neurons. The core of NF-180 was similar in structure to those of mammalian neurofilaments, but surprisingly, the carboxy sidearm lacked the multiphosphorylation repeats characteristic of higher vertebrate and invertebrate neurofilaments. Overall there was a paucity of potential phosphorylation sites in the NF-180 carboxy-terminus compared to NF-M and NF-H of mammals, fish and squid. This, along with the highly acidic nature of the NF-180 sidearm, makes it unlikely that phosphorylation of sidearm residues regulates interfilament spacing and axon diameter through global electrostatic repulsion of the carboxy-terminus away from the filament backbone. Furthermore, the expression of a single neurofilament subunit in the lamprey that is most similar to the NF-M of higher vertebrates suggests that all three mammalian neurofilament subunits evolved from a single NF-M-like precursor.