gebhart/patrepeval huggingface dataset:
<i>Mycobacterium</i> Species Identification and Rifampin Resistance Testing with High-Density DNA Probe Arrays (1999)

Species identification within the genus Mycobacterium and subsequent antibiotic susceptibility testing still rely on time-consuming, culture-based methods. Despite the recent development of DNA probes, which greatly reduce assay time, there is a need for a single platform assay capable of answering the multitude of diagnostic questions associated with this genus. We describe the use of a DNA probe array based on two sequence databases: one for the species identification of mycobacteria (82 unique 16S rRNA sequences corresponding to 54 phenotypical species) and the other for detecting Mycobacterium tuberculosis rifampin resistance (rpoB alleles). Species identification or rifampin resistance was determined by hybridizing fluorescently labeled, amplified genetic material generated from bacterial colonies to the array. Seventy mycobacterial isolates from 27 different species and 15 rifampin-resistant M. tuberculosis strains were tested. A total of 26 of 27 species were correctly identified as well as all of the rpoB mutants. This parallel testing format opens new perspectives in terms of patient management for bacterial diseases by allowing a number of genetic tests to be simultaneously run.
Comparative proteomics of Cannabis sativa plant tissues. (2004)

Comparative proteomics of leaves, flowers, and glands of Cannabis sativa have been used to identify specific tissue-expressed proteins. These tissues have significantly different levels of cannabinoids. Cannabinoids accumulate primarily in the glands but can also be found in flowers and leaves. Proteins extracted from glands, flowers, and leaves were separated using two-dimensional gel electrophoresis. Over 800 protein spots were reproducibly resolved in the two-dimensional gels from leaves and flowers. The patterns of the gels were different and little correlation among the proteins could be observed. Some proteins that were only expressed in flowers were chosen for identification by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and peptide mass fingerprint database searching. Flower and gland proteomes were also compared, with the finding that less then half of the proteins expressed in flowers were also expressed in glands. Some selected gland protein spots were identified: F1D9.26-unknown prot. (Arabidopsis thaliana), phospholipase D beta 1 isoform 1a (Gossypium hirsutum), and PG1 (Hordeum vulgare). Western blotting was employed to identify a polyketide synthase, an enzyme believed to be involved in cannabinoid biosynthesis, resulting in detection of a single protein.
Data Partitioning Technique for Improved Video Prioritization (2017)

A compressed video bitstream can be partitioned according to the coding priority of the data, allowing prioritized wireless communication or selective dropping in a congested channel. Known as data partitioning in the H.264/Advanced Video Coding (AVC) codec, this paper introduces a further sub-partition of one of the H.264/AVC codec’s three data-partitions. Results show a 5 dB improvement in Peak Signal-to-Noise Ratio (PSNR) through this innovation. In particular, the data partition containing intra-coded residuals is sub-divided into data from: those macroblocks (MBs) naturally intra-coded, and those MBs forcibly inserted for non-periodic intra-refresh. Interactive user-to-user video streaming can benefit, as then HTTP adaptive streaming is inappropriate and the High Efficiency Video Coding (HEVC) codec is too energy demanding.
The New α-Amino Acid <i>N</i><sup>ω</sup>-Hydroxy-nor-<scp>l</scp>-arginine:  a High-Affinity Inhibitor of Arginase Well Adapted To Bind to Its Manganese Cluster (1997)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTThe New α-Amino Acid Nω-Hydroxy-nor-l-arginine: a High-Affinity Inhibitor of Arginase Well Adapted To Bind to Its Manganese ClusterJ. Custot, C. Moali, M. Brollo, J. L. Boucher, M. Delaforge, D. Mansuy, J. P. Tenu, and J. L. ZimmermannView Author Information Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, URA 400 CNRS Université René Descartes, 45 rue des Saints-Pères 75270 Paris Cedex 06, France CNRS, URA 1116, Bât. 432 Université Paris XI, 91405 Orsay, France CEA/Saclay, Département de Biologie Cellulaire et Moléculaire, Section de Bioénergétique Bât. 532, 91191 Gif Sur Yvette, France Cite this: J. Am. Chem. Soc. 1997, 119, 17, 4086–4087Publication Date (Web):April 30, 1997Publication History Received28 January 1997Published online30 April 1997Published inissue 1 April 1997https://pubs.acs.org/doi/10.1021/ja970285ohttps://doi.org/10.1021/ja970285orapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views1673Altmetric-Citations80LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Anatomy,Electron paramagnetic resonance spectroscopy,Inhibitors,Rodent models,Transition metals Get e-Alerts
THE RELATIONSHIP BETWEEN SPREADING FACTOR AND HYALURONIDASE (1941)

A comparative study of spreading factor and hyaluronidase in preparations from various sources revealed the following points of similarity and dissimilarity in the two reactions. 1. Similarities: (a) All preparations containing hyaluronidase also produced spreading. (b) Heating at 65 degrees and 100 degrees C. for 30 minutes produced a comparable effect on both reactions. (c) The demonstration of the presence of hyaluronic acid in skin offers a plausible explanation for the mechanism of spreading on the basis of hyaluronidase activity. 2. Dissimilarities: (a) No parallelism was observed in the degree of activity of spreading factor and hyaluronidase in the same preparations. (b) All preparations which produced spreading did not contain hyaluronidase. (c) Antisera to hyaluronidase preparations specifically and completely inhibited the activity of the homologous enzyme but did not inhibit the spreading factor in the same preparations. The significance of the similarities and dissimilarities between the two reactions is discussed. It is concluded that while hyaluronidase may play a rôle in the spreading reaction the phenomenon is a complex one and cannot be explained on the basis of a simple chemical reaction.
Merging and comparing ontologies (2005)

Abstract The use of formal systems to define biomedical concepts and to represent and store biomedical knowledge has never been more important to the informatics community. In the past few years, ontologies have become the cornerstone of the information‐systems research. With the wider use of ontologies, the problem of ontology management began to arise: ontology developers and users must be able to find and compare existing ontologies or their parts, merge and align ontologies, compare different versions, and translate ontologies from one formalism to another. We describe various approaches to the ontology‐management tasks and the recent developments in defining a general ontology‐management framework.
Effect of Troglitazene on Microalbuminuria in Patients With Incipient Diabetic Nephropathy (1998)

Troglitazone ameliorated microalbuminuria in diabetic nephropathy. Furthermore, our findings suggest that troglitazone has some effects on vascular cells other than lowering plasma glucose levels. Troglitazone might be useful for diabetic angiopathy, including nephropathy and coronary artery disease.
Sistema basado en modelos de simulación para la valoración de empresas. (2005)

Un topico que causa gran preocupacion, en el campo financiero, es la valoracion de empresas, ya que es una informacion muy dificil de calcular con certeza, pero de suma importancia para establecer muchos procesos de negociacion, sobre todo cuando se trata de adquisiciones y fusiones. Dada esta dificultad, de lograr una buena valoracion de las organizaciones, se consiguen en la literatura especializada, una gran cantidad de metodos que pretenden arrojar alguna luz sobre tan intrincado campo. Partiendo de esta inquietud ha surgido la presente investigacion, cuyo objetivo se puede enunciar: Describir un sistema computacional, que basado en modelos de simulacion, pueda ofrecer en forma rapida y a bajo costo, una aproximacion del valor estimado de una organizacion.
Vitamin D Insufficiency (2011)

The author reviews data supporting the recommendation to maintain a serum concentration of vitamin D above 20 ng per milliliter and notes the lack of evidence to support a higher target level. He reviews the limitations of data linking vitamin D insufficiency to chronic disease risk.
Liveness Detection Using Gaze Collinearity (2012)

This paper presents a liveness detection method based on tracking the gaze of the user of a face recognition system using a single camera. The user is required to follow a visual animation of a moving object on a display screen while his/her gaze is measured. The visual stimulus is designed to direct the gaze of the user to sets of collinear points on the screen. Features based on the measured collinearity of the observed gaze are then used to discriminate between live attempts at responding to this challenge and those conducted by "impostors" holding photographs and attempting to follow the stimulus. An initial set of experiments is reported that indicates the effectiveness of the proposed method in detecting this class of spoofing attacks.
Low-Impairment Mud System for Drilling Horizontal Wells Through Clastic Reservoirs in a South Oman Oil Field (1993)

Abstract This paper discusses the development, field experience, cost aspects and the consequences of using a low-impairment drilling fluid system for drilling horizontal wells targeted on clastic reservoirs in a South Oman oil field in the concession area of Petroleum Development Oman [PDO], The first horizontal well was drilled in January 1990 and by October 1992 a total of twenty three wells had been drilled and completed in the field. The first five wells were drilled using conventional water based systems. But once the horizontal well scenario had been proven, subsequent wells were drilled with a fit-for-purpose low-impairment drilling fluid system formulated for specific hole sections. Progressive changes in well and mud design, as well as the optimization of drilling practices, have resulted in significant reductions in drilling times and well costs and increased well productiviities.
Humic Substances In Soil, Sediment, And Water : Geochemistry, Isolation, And Characterization (1985)

An Introduction to Humic Substances in Soil, Sediment, and Water GEOCHEMISTRY OF HUMIC SUBSTANCES: Geochemistry of Soil Humic Substances Geochemistry of Humic Substances in Natural and Cultivated Peatlands Humic Substances in Groundwater Geochemistry and Ecological Role of Humic Substances in Lakewater Geochemistry of Humic Substances in Lake Sediments Geochemistry of Stream Fulvic and Humic Substances Geochemistry of Humic Substances in Estuarine Environments Geochemistry of Humic Substances in Seawater Geochemistry of Humic Substances in Marine Sediments Geochemistry of Humin Nature of Nitrogen in Humic Substances ISOLATION AND FRACTIONATION OF HUMIC SUBSTANCES: Extraction of Humic Substances from Soil Isolation and Concentration Techniques for Aquatic Humic Substances Fractionation of Soil Humic Substances Fractionation Techniques for Aquatic Humic Substances CHARACTERIZATION OF HUMIC SUBSTANCES: Analytical Methodology for Elemental Analysis of Humic Substances Implications of Elemental Characteristics of Humic Substances Molecular Size and Weight Measurements of Humic Substances Acidic Functional Groups of Humic Substances Spectroscopic Methods (other than NMR) for Determining Functionality in Humic Substances Application of Nuclear Magnetic Resonance Spectroscopy for Determining Functionality in Humic Substances Concluding Remarks Bibliography Appendixes Index.
A Cleavable Affinity Biotinylating Agent Reveals a Retinoid Binding Role for RPE65 (2003)

Retinal pigment epithelial (RPE) membranes contain the full biochemical apparatus capable of processing all-trans-retinol (vitamin A) into 11-cis-retinal, the visual chromophore. As many of these proteins are integral membrane proteins and resistant to traditional methods of identification, alternate methods of identifying these proteins are sought. The approach described here involves affinity biotinylation with alkali cleavable linkers. A vitamin A containing affinity-labeling haloacetate is described which facilitates the identification of retinoid binding proteins (RBPs). Treatment of crude bovine RPE membranes with (3R)-3-[boc-lys(biotinyl)-O]-all-trans-retinol chloroacetate 1 in the low micromolar range led to the specific labeling of RPE65 and lecithin retinol acyltransferase (LRAT). Only RPE65 is labeled at 5 microM 1 at 4 degrees C. Labeled RPE65 was readily isolated by binding the labeled protein to avidin-containing beads, followed by cleavage of the protein from the beads at pH 11. Trypsin digestion of RPE65 modified by 1, followed by mass spectrometry, demonstrates that C231 and C448 are alkylated by 1. These studies validate the approach that was used, and furthermore demonstrate that RPE65, a major membrane-associated protein of the RPE, is a RBP.
Vía Aérea Difícil Desconocida en pacientes obstétricas (2013)

La Vía Aérea Difícil (VAD) supone un auténtico desafío en las pacientes obstétricas no habiéndose establecido un consenso para su manejo o un algoritmo universalmente aceptado. La “causa anestésica” permanece en la lista de primeras causas de mortalidad materna, y el manejo de la vía aérea lidera esta categoría. La dificultad de intubación en estas pacientes llega a ser hasta 10 veces mayor que en la población general, por lo que la altísima morbi-mortalidad tanto materna como fetal asociada a un manejo deficiente la vía aérea desconocida en la paciente obstétrica exige más atención.
Efficient audit-based compliance for relational data retention (2011)

The Sarbanes-Oxley Act inspired research on long-term high-integrity retention of business records, leveraging the immutability guarantees that WORM storage servers offer for files. In this paper, we present the transaction log on WORM (TLOW) approach for supporting long-term immutability for relational tuples. TLOW stores the transaction log on WORM and uses an audit helper (AH) add-on to continuously perform audit-related activities without compromising transaction performance or audit trustworthiness. TLOW imposes only 1-11% runtime overhead on TPC-C transactions, much less than previously proposed approaches, and does not require DBMS kernel changes. TLOW audits are extremely fast, e.g., two hours to audit a year of continuous TPC-C activity, versus 10 days for previously proposed approaches. This opens up the possibility of real-time internal audits that can detect fraudulent activity before its effects propagate throughout an enterprise. We also provide a proof of correctness for TLOW, which exposes a subtle threat that affects the correctness of previously proposed approaches.
Performance Analysis of Electrodynamic Self-Cleaning Transparent Films for its Applications to Mars and Lunar Missions (2007)

The performance of Electrodynamic Screen (EDS) for surface cleaning was characterized with respect to the following operational parameters: (1) the efficiency of screens under both continuous and intermittent operations with different rates of dust deposition, (2) electrical power requirements for the screen operation with respect frequency of excitation and duration of the applied power needed to remove dust particles as a function of dust loading, and (3) the optical transmission efficiency of the films for the screens with and without transparent indium tin oxide (ITO) electrodes. The average dust removal efficiency of EDS during continuous dust loading was over 95%, whereas it was 90% when the screen was activated intermittently. The corresponding optical transmission efficiency was also measured. The rate of continuous dust loading on screen was equivalent to the estimated amount of one year dust deposition on the surface of Mars. This estimation was based on average obscuration rate of 0.29% per day as measured during Mars Adherence Experiment and reported by Landis. Power consumption by EDS as well as the size and weight of the power supply is one of the critical factors for its applicability for dust removal from solar panels during future Mars mission. The power consumption by EDS was measured under several dust loadings and using different frequencies and electrical field intensities for the safe operation of power supplies without Paschen breakdown. Experiments were conducted under both Earth and simulated Martian atmosphere (5.0 mb CO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> atmosphere). The average power consumption of screen varied between 0.8 mW to 1.21 mW, when operating at atmospheric pressure and from 1.02 mW to 2.87 mW under simulated Martian atmosphere. The power supply requires approximately 5 W for its operation under no load condition and it is estimated that the total power consumption will be approximately 10 W per meter square, 5 W for the supply operation and the additional 5 W for cleaning the dust with a dust load of 0.64 mg/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> .
Properties and Microstructure of Allvac 718Plus Alloy Rolled Sheet (2005)

Design and construction of advanced aerospace systems capable of meeting demands of accessto-space, operations in and through space, and high speed/hypersonic flight are constrained by material challenges. Requirements for airplane-like operations of reusable systems fall most heavily on the needs for improved thermal protection systems and durable, lightweight structures. Robust and affordable industrial manufacturing procedures for these material systems frequently do not exist, even for materials such as some nickel-based superalloys, which have attractive high-temperature performance, manufacturability, cost and durability.
Puromycin. Synthetic Studies. XI. D-Ribofuranosyl Derivatives of 6-Dimethylaminopurine (1955)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPuromycin. Synthetic Studies. XI. D-Ribofuranosyl Derivatives of 6-DimethylaminopurineHenry M. Kissman, Charles Pidacks, and B. R. BakerCite this: J. Am. Chem. Soc. 1955, 77, 1, 18–24Publication Date (Print):January 1, 1955Publication History Published online1 May 2002Published inissue 1 January 1955https://pubs.acs.org/doi/10.1021/ja01606a005https://doi.org/10.1021/ja01606a005research-articleACS PublicationsRequest reuse permissionsArticle Views335Altmetric-Citations57LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Synthesis and Inhibitory Activity Evaluation of 2,6‐Disubstituted Purine Derivatives (2014)

A series of novel 2,6‐disubstituted purine derivatives were designed and synthesized from 2,6‐dichloropurine. The structures of target compounds were determined by 1 H‐NMR, 13 C‐NMR, and HRMS. The synthesized compounds were evaluated for their inhibitory activities against lung cancer cell lines of A549 and liver cancer cell lines of Bel‐7402. 2‐(4‐Benzyloxy‐phenylamino)‐6‐(cyclohexylamino)purine( 3 ), 2‐(4‐chloro‐phenylamino)‐6‐( n ‐butylamino)purine ( 5 ), 2‐(4‐morpholinoamino)‐6‐(4‐hydroxy‐phenylamino)purine ( 9 ), and 2‐(4‐ O ‐galactosyl‐phenylamino)‐6‐(cyclohexylamino)purine ( 12 ) exhibited moderate inhibitory activity.
Robot-aided neurorehabilitation (1998)

Our goal is to apply robotics and automation technology to assist, enhance, quantify, and document neurorehabilitation. This paper reviews a clinical trial involving 20 stroke patients with a prototype robot-aided rehabilitation facility developed at the Massachusetts Institute of Technology, Cambridge, (MIT) and tested at Burke Rehabilitation Hospital, White Plains, NY. It also presents our approach to analyze kinematic data collected in the robot-aided assessment procedure. In particular, we present evidence 1) that robot-aided therapy does not have adverse effects, 2) that patients tolerate the procedure, and 3) that peripheral manipulation of the impaired limb may influence brain recovery. These results are based on standard clinical assessment procedures. We also present one approach using kinematic data in a robot-aided assessment procedure.
Loss of Calcium-Homeostatic Mechanisms in Polymorphonuclear Leukocytes of Demented and Nondemented Elderly Subjects (1993)

The calcium homeostatic mechanisms were explored in 31 aged individuals some of whom suffered from dementia (11 Alzheimer's disease, 5 other dementias, 15 cognitively normal individuals). Their mean age was 81.2 +/- 9.2 years, varying from 60 to 96 years. Polymorphonuclear leukocytes (PMNs) were isolated from freshly drawn citrated blood and loaded with Fura-2. Resting intracellular free calcium values, [Ca2+]o, were recorded as well as the calcium transients produced by formyl-methionyl-leucyl-phenylalanine 10(-8) M:delta [Ca2+]i. The return to prestimulation values was also recorded. Average [Ca2+]o was 64.6 +/- 16.0 nM and the average delta [Ca2+]i 77.6 +/- 52.7 nM. No correlation was found with age within the range explored nor was there any difference in calcium transients between demented and nondemented patients. The most surprising finding was the inability of about 30% of all examined patients' PMNs to return the elevated [Ca2+]i values to prestimulation values. For some patients, elevated [Ca2+]i remained at the higher value, for others [Ca2+]i continued to rise. Those who could down-regulate poststimulation values did it only very slowly. Previous results obtained with leukocytes from younger individuals (under 45 years) showed a rapid return to prestimulation values. It appears that this loss of calcium-homeostatic mechanisms in old individuals is a progressive process which involves a relatively high proportion of the investigated subjects. The rate of decrease of intracellular calcium (measured by the slope P) did not correlate with diagnosis.(ABSTRACT TRUNCATED AT 250 WORDS)