gebhart/patrepeval huggingface dataset:
Biophysical Investigation of the Iron in Aft1-1<sup>up</sup> and Gal-YAH1 <i>Saccharomyces cerevisiae</i> (2011)

Aft1p is a major iron regulator in budding yeast Saccharomyces cerevisiae. It indirectly senses cytosolic Fe status and responds by activating or repressing iron regulon genes. Aft1p within the Aft1-1(up) strain has a single amino acid mutation which causes it to constitutively activate iron regulon genes regardless of cellular Fe status. This leads to elevated Fe uptake under both low and high Fe growth conditions. Ferredoxin Yah1p is involved in Fe/S cluster assembly, and Aft1p-targeted iron regulon genes are also upregulated in Yah1p-depleted cells. In this study Mössbauer, EPR, and UV-vis spectroscopies were used to characterize the Fe distribution in Aft1-1(up) and Yah1p-depleted cells. Aft1-1(up) cells grown in low Fe medium contained more Fe than did WT cells. A basal level of Fe in both WT and Aft1-1(up) cells was located in mitochondria, primarily in the form of Fe/S clusters and heme centers. The additional Fe in Aft1-1(up) cells was present as mononuclear HS Fe(III) species. These species are in a nonmitochondrial location, assumed here to be vacuolar. Aft1-1(up) cells grown in high Fe medium contained far more Fe than found in WT cells. The extra Fe was present as HS Fe(III) ions, probably stored in vacuoles, and as Fe(III) phosphate nanoparticles, located in mitochondria. Yah1p-deficent cells also accumulated nanoparticles in their mitochondria, but they did not contain HS Fe(III) species. Results are interpreted by a proposed model involving three homeostatic regulatory systems, including the Aft1 system, a vacuolar iron regulatory system, and a mitochondrial Fe regulatory system.
Investigation of a laser-produced atomic beam (1994)

The acceleration of a thin layer mounted on the rear surface of a thick transparent slab target was shown to be feasible with a laser of moderate energy. Both long (about 1 ns) and short (about 25 ps) laser pulse interactions were investigated. Using a single laser beam with 2 J in a 1 ns pulse it was possible to accelerate an Al layer of thickness <or=1 mu m up to a velocity of 2*106 cm s-1. Atomic beam velocity distributions were measured with a time-of-flight neutral particle detector and a time-gated micro-channel plate neutral particle pin-hole camera. The expanding atomic beam was confined to a very narrow cone, being directed along the normal to the target rear surface and independent of the laser beam axis. Time-resolved imaging of the target rear surface in different spectral bands provided measurements of its temperature and the characteristic scale-length of the atomic beam emission area.
5‐Amino‐1‐naphthol, a novel 1,5‐naphthalene derivative matrix suitable for matrix‐assisted laser desorption/ionization in‐source decay of phosphorylated peptides (2012)

The newly introduced matrix 5,1-ANL gave highest ion yields of ISD fragments from mono-, di-, and tetraphosphorylated peptides, while 1,5-DAN was poor in the ISD ion yields for phosphorylated peptides.
Application of the Grayscale Standard Display Function to General Purpose Liquid-crystal Display Monitors for Clinical Use (2010)

Interpretations of medical images have been shifting to soft-copy readings with liquid-crystal display (LCD) monitors. The display function of the medical-grade LCD monitor for soft-copy readings is recommended to calibrate the grayscale standard display function (GSDF) in accordance with the guidelines of Japan and other countries. In this study, the luminance and display function of five models of eight general purpose LCD monitors were measured to gain an understanding of their characteristics. Moreover, the display function (gamma 2.2 or gamma 1.8) of general purpose LCD monitors was converted to GSDF through the use of a look-up table, and the detectability of a simulated lung nodule in the chest x-ray image was examined. As a result, the maximum luminance, contrast ratio, and luminance uniformity of general purpose LCD monitors, except for one model of two LCD monitors, met the management grade 1 standard in the guideline JESRA X-0093-2005. In addition, the detectability of simulated lung nodule in the mediastinal space was obviously improved by converting the display function of a general purpose LCD monitor into GSDF.
Praseodymium/Polyureasulfone Complexes with Unusual Thermal, Luminescent and Magnetic Properties (2010)

Abstract A soluble praseodymium complex was synthesized using a polymeric PUDS ligand. FTIR and Raman spectra suggest that the >NH lone pair in PUDS can interact with the Pr 3+ centers. DSC results show that the coordination effect causes a significant increase of the phase transition temperature. The emission spectrum of Pr‐PUDS indicates an efficient energy transfer from the macromolecular ligand to the coordinated Pr 3+ ion. The magnetic behavior as function of applied magnetic field or temperature (50–450 °C) and some unusual transitions in the M versus T plots are reported and discussed, which demonstrate that the magnetic properties of the Pr‐PUDS strongly depend on the phase transition. magnified image
<title>Collaborative volume visualization with applications to underwater acoustic signal processing</title> (2000)

Distributed collaborative visualization systems represent a technology whose time has come. Researchers at the Fraunhofer Center for Research in Computer Graphics have been working in the areas of collaborative environments and high-end visualization systems for several years. The medical application. TeleInVivo, is an example of a system which marries visualization and collaboration. With TeleInvivo, users can exchange and collaboratively interact with volumetric data sets in geographically distributed locations. Since examination of many physical phenomena produce data that are naturally volumetric, the visualization frameworks used by TeleInVivo have been extended for non-medical applications. The system can now be made compatible with almost any dataset that can be expressed in terms of magnitudes within a 3D grid. Coupled with advances in telecommunications, telecollaborative visualization is now possible virtually anywhere. Expert data quality assurance and analysis can occur remotely and interactively without having to send all the experts into the field. Building upon this point-to-point concept of collaborative visualization, one can envision a larger pooling of resources to form a large overview of a region of interest from contributions of numerous distributed members.
A combination therapy of continuous superselective intraarterial carboplatin infusion and radiation therapy for locally advanced head and neck carcinoma. Phase I study. (2000)

Superselective continuous intraarterial carboplatin and concurrent radiation therapy can be delivered safely with good efficacy for locally advanced carcinomas of the tongue and base of the tongue. Surgical treatment of these diseases usually incurs severe functional loss. This current approach may be a breakthrough in these cancers.
Two high-affinity enolase inhibitors. Reaction with enolases (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTwo high-affinity enolase inhibitors. Reaction with enolasesThomas G. Spring and Finn WoldCite this: Biochemistry 1971, 10, 25, 4655–4660Publication Date (Print):December 7, 1971Publication History Published online1 May 2002Published inissue 7 December 1971https://pubs.acs.org/doi/10.1021/bi00801a010https://doi.org/10.1021/bi00801a010research-articleACS PublicationsRequest reuse permissionsArticle Views208Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Application of FTIR Spectroscopy in Environmental Studies (2012)

FTIR Spectroscopy is a technique based on the determination of the interaction between an IR radiation and a sample that can be solid, liquid or gaseous. It measures the frequencies at which the sample absorbs, and also the intensities of these absorptions. The frequencies are helpful for the identification of the sample’s chemical make-up due to the fact that chemical functional groups are responsible for the absorption of radiation at different frequencies. The concentration of component can be determined based on the intensity of the absorption. The spectrum is a two-dimensional plot in which the axes are represented by intensity and frequency of sample absorption.
Impact of soluble fms-like tyrosine kinase-1 and placental growth factor serum levels for risk stratification and early diagnosis in patients with suspected acute myocardial infarction (2010)

ClinicalTrials.gov, NCT00470587.
The Modeling of Deviated Wells and Sloping Faults With Locally Unstructured Grids: Part 1—Gridding Aspects (1993)

Abstract Today, reservoir geometry and heterogeneity configurations can be determined more accurately than ever before. Heterogeneities can cause severe saturation discontinuities and create very non-uniform drainage patterns. Existence of deviated wells can complicate the flow domain further. It is important that the simulation grids used should represent the exact geometry of the reservoir heterogeneity and conform to the natural flow pattern around wells. In most finite difference simulation models, the reservoir is divided into an array of topologically rectangular grid blocks. These structured grids yield efficient solution of the resulting set of algebraic equations [Wallis (1)]. However, because of their logically rectangular structure, these grids do not have the flexibility to conform to reservoir geometry and heterogeneity configurations. Specifically they can not represent deviated wells and sloping faults accurately. Unstructured finite element grid blocks can be assembled to assume almost any shape and are better suited for geologically complex heterogeneous reservoirs. However solution techniques for unstructured grids are costlier, making locally unstructured grids a viable choice for these reservoirs.
Metallic ions in the upper atmosphere of Mars from the passage of comet C/2013 A1 (Siding Spring) (2015)

Abstract We report the first in situ detection of metal ions in the upper atmosphere of Mars resulting from the ablation of dust particles from comet Siding Spring. This detection was carried out by the Neutral Gas and Ion Mass Spectrometer on board the Mars Atmosphere and Volatile Evolution Mission. Metal ions of Na, Mg, Al, K, Ti, Cr, Mn, Fe, Co, Ni, Cu, and Zn, and possibly of Si, and Ca, were identified in the ion spectra collected at altitudes of ~185 km. The measurements revealed that Na + was the most abundant species, and that the remaining metals were depleted with respect to the CI (type 1 carbonaceous Chondrites) abundance of Na + . The temporal profile and abundance ratios of these metal ions suggest that the combined effects of dust composition, partial ablation, differential upward transport, and differences in the rates of formation and removal of these metal ions are responsible for the observed depletion.
Morgan, Thomas (d. 1743) (1999)

Morgan, Thomas Thomas Morgan was born in Wales and died on 14 January 1743. He was at one time a dissenting minister at Frome, Somerset, from which position he was dismissed for holding deistic opinions. He began to publish in the wake of the ‘Salters’ Hall’ controversy in 1719, arguing that dissent
Estimation of Bladder Volume From Afferent Neural Activity (2013)

Refractive urinary dysfunction in individuals suffering from neurogenic bladder syndrome can be treated with implanted neurostimulators that restore, to some degree, the control of the urinary bladder. A sensor capable of relaying feedback from bladder activity to the implanted neurostimulator is required to implement a closed-loop system to improve overall implant efficacy and minimize deleterious effects to neural tissue caused by continuous electrical stimulation. In this paper, we present a method that allows real-time estimation of bladder volume from the primary afferent activity of bladder mechanoreceptors. Our method was validated with data acquired from anesthetized rats in acute experiments. It was possible to qualitatively estimate three states of bladder fullness in 100% of trials when the recorded afferent activity exhibited a Spearman's correlation coefficient of 0.6 or better. Furthermore, we could quantitatively estimate bladder volume, and also its pressure, using timeframes of properly chosen duration. The mean volume estimation error was 5.8±3.1%. Our results also demonstrate that it is possible to quantify both phasic and tonic bladder responses during slow filling and isovolumetric measurements, respectively.
Purification and characterization of <i>Klebsiella aerogenes</i> UreE protein: A nickel‐binding protein that functions in urease metallocenter assembly (1993)

The Klebsiella aerogenes ureE gene product was previously shown to facilitate assembly of the urease metallocenter (Lee, M.H., et al., 1992, J. Bacteriol. 174, 4324-4330). UreE protein has now been purified and characterized. Although it behaves as a soluble protein, UreE is predicted to possess an amphipathic beta-strand and exhibits unusually tight binding to phenyl-Sepharose resin. Immunogold electron microscopic studies confirm that UreE is a cytoplasmic protein. Each dimeric UreE molecule (M(r) = 35,000) binds 6.05 + 0.25 nickel ions (Kd of 9.6 +/- 1.3 microM) with high specificity according to equilibrium dialysis measurements. The nickel site in UreE was probed by X-ray absorption and variable-temperature magnetic circular dichroism spectroscopies. The data are most consistent with the presence of Ni(II) in pseudo-octahedral geometry with 3-5 histidyl imidazole ligands. The remaining ligands are nitrogen or oxygen donors. UreE apoprotein has been crystallized and analyzed by X-ray diffraction methods. Addition of nickel ion to apoprotein crystals leads to the development of fractures, consistent with a conformational change upon binding nickel ion. We hypothesize that UreE binds intracellular nickel ion and functions as a nickel donor during metallocenter assembly into the urease apoprotein.
ScanMed: A Mobile Medicine Adherence Application with Intake Validation Using QR Code (2016)

The impact of medication adherence is proven to affect hospitalization risk and healthcare cost. In Malaysia, failure in taking medication as prescribed is a complicated and common problem. There are many reasons people fail to take their medication as prescribed. Some of the few common issues are remembering to consume their medicine timely, doubts in medication effectiveness, concerns on side effects or having difficulty in taking the medication (especially with injections or inhalers) and rising cost of prescribed medications. Tracking patient medication intake leads to many advantages, one of which is lower medication due to adherence, health-care cost which effects insurance coverage premiums. In this paper, we develop an application to track medication using a smart phone and the use of QR code. Each medication transaction requires a proof of work to signify that the user have taken their medication at the correct date and time. A QR-Code reader will be used to capture medication taken printed on medication labels and each scan is considered as a proof of work. Our contribution is to create a mobile application that can help track medication intake, as well as remind, inform and warn users about the medication that they are taking.
Metabotropic glutamate receptor 1 (mGluR1) and 5 (mGluR5) regulate late phases of LTP and LTD in the hippocampal CA1 region <i>in vitro</i> (2008)

The group I metabotropic glutamate receptors, mGluR1 and mGluR5, exhibit differences in their regulation of synaptic plasticity, suggesting that these receptors may subserve separate functional roles in information storage. In addition, although effects in vivo are consistently described, conflicting reports of the involvement of mGluRs in hippocampal synaptic plasticity in vitro exist. We therefore addressed the involvement of mGluR1 and mGluR5 in long-term potentiation (LTP) and long-term depression (LTD) in the hippocampal CA1 region of adult male rats in vitro. The mGluR1 antagonist (S)-(+)-alpha-amino-4-carboxy-2-methylbenzene-acetic acid (LY367385) impaired both induction and late phases of both LTP and LTD, when applied before high-frequency tetanization (HFT; 100 Hz) or low-frequency stimulation (LFS; 1 Hz), respectively. Application after either HFT or LFS had no effect. The mGluR5 antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP), when given before HFT, inhibited both the induction and late phases of LTP. When given after HFT, late LTP was inhibited. MPEP, given prior to LFS, impaired LTD induction, although stable LTD was still expressed. Application after LFS significantly impaired late phases of LTD. Activation of protein synthesis may comprise a key mechanism underlying the group I mGluR contribution to synaptic plasticity. The mGluR5 agonist (R,S)-2-chloro-5-hydroxyphenylglycine (CHPG) converted short-term depression into LTD. Effects were prevented by application of the protein synthesis inhibitor anisomycin, suggesting that protein synthesis is triggered by group I mGluR activation to enable persistency of synaptic plasticity. Taken together, these data support the notion that both mGluR1 and mGluR5 are critically involved in bidirectional synaptic plasticity in the CA1 region and may enable functional differences in information encoding through LTP and LTD.
Simultaneous Suppression of Epidermal Growth Factor Receptor and c-erbB-2 Reverses Aneuploidy and Malignant Phenotype of a Human Ovarian Carcinoma Cell Line (2004)

Coexpression of epidermal growth factor receptor (EGFR) and c-erbB-2 in 47-68% of ovarian cancer cells indicate their strong association with tumor formation. We examined the effects of simultaneous antisense- or immunosuppression of EGFR and c-erbB-2 expression on the invasive phenotype, aneuploidy, and genotype of cultured human ovarian carcinoma cells (NIH:OVCAR-8). We report here that suppression of both EGFR and c-erbB-2 results in regression of aneuploidy and genomic imbalances in NIH:OVCAR-8 cells, restores a more normal phenotype, and results in a more normal gene expression profile. Combined with cytogenetic analysis, our data demonstrate that the regression of aneuploidy is due to the selective apoptosis of double antisense transfected cells with highly abnormal karyotype.
Precision of seafloor gravity and pressure measurements for reservoir monitoring (2008)

Abstract Changes with gravity over time have proven to be valuable for inferring subsurface density changes associated with production from oil and natural gas reservoirs. Such inferences allow the monitoring of moving fluid fronts in a reservoir and provide an opportunity to optimize production over the life of the reservoir. Our group began making time-lapse seafloor gravity and pressure measurements in 1998. To date, we have surveyed six fields offshore Norway; we have made three repeat surveys at one field and one repeat survey at another. We incorporated a land-gravity sensor into a remotely operated seafloor housing. Three such relative gravity sensors mounted in a single frame are carried by a remotely operated vehicle (ROV) to concrete benchmarks permanently placed on the seafloor. Reference benchmarks sited outside the reservoir boundaries are assumed to provide stable fiducial points. Typical surveys last from a few days to a few weeks and cover from 8 to 80 benchmarks, with multiple observations of each. In our earliest surveys, we obtained an intrasurvey repeatability of approximately 20μGal, but recently we have been achieving 3-μGal repeatability in gravity and approximately 5mm in benchmark depth (deduced from simultaneously recorded ambient seawater pressure). We attribute the improved precision to several operational factors, including the use of multiple gravity sensors, frequent benchmark reoccupation, precise relocation and orientation of the sensors, repeated calibrations on land, and minimization of vibrational and thermal perturbations to the sensors. We believe that high-precision time-lapse gravity monitoring can be used to track changes in the height of a gas-water contact in a flooded reservoir, with a precision of a few meters.
Mitral Valve and Tricuspid Valve Blood Flow: Accurate Quantification with 3D Velocity-encoded MR Imaging with Retrospective Valve Tracking (2008)

Use of 3D three-directional VE MR imaging enables accurate MV and TV flow quantification, even in patients with valve regurgitation.
Measurement of regional wall motion from biplane contrast ventriculograms: a comparison of the 30 degree right anterior oblique and 60 degree left anterior oblique projections in patients with acute myocardial infarction. (1986)

The value of performing biplane vs single plane analysis of regional wall motion from contrast ventriculograms was determined in 102 patients who received thrombolytic therapy and who underwent biplane ventriculography during acute myocardial infarction (n = 67), at follow-up more than 2 weeks later (n = 80), or both (n = 45). Hypokinesis in the infarct region and hyperkinesis in the noninfarct region were measured by the centerline method in the respective artery territories, which were defined from the data of 62 patients with single-vessel disease and were expressed in units of standard deviations from the mean of 32 normal subjects. Hypokinesis was more severe and extended over a longer segment of the left ventricular contour when measured in the right anterior oblique (RAO) projection in thrombosis of the left anterior descending coronary artery (LAD) but more severe and extensive in the left anterior oblique (LAO) projection in circumflex stenosis. Hyperkinesis opposite the LAD or the circumflex was greater in the LAO projection. In patients with thrombosis of the right coronary artery, wall motion abnormalities were similar in the two projections. Thus the evaluation of hypokinesis caused by acute coronary thrombosis and of the effect of therapeutic interventions in salvaging function can be adequately evaluated from single-plane 30 degree RAO ventriculograms, except in the small minority of patients with circumflex thrombosis.