gebhart/patrepeval huggingface dataset:
First-line monotherapy with nivolumab (NIVO; anti-programmed death-1 [PD-1]) in advanced non-small cell lung cancer (NSCLC): Safety, efficacy and correlation of outcomes with PD-1 ligand (PD-L1) expression. (2015)

8025 Background: NIVO, a fully human IgG4 PD-1 immune checkpoint inhibitor antibody, has demonstrated durable responses and tolerability in heavily pretreated patients (pts) with advanced NSCLC. This phase I study evaluated the efficacy and safety of NIVO monotherapy in pts with chemotherapy naïve advanced NSCLC. Methods: Pts (N=52) with squamous (SQ) or non-SQ advanced NSCLC received NIVO 3 mg/kg IV Q2W until progression or unacceptable toxicity (post-progression treatment was permitted per protocol). Response (RECIST v1.1) was evaluated overall, by histology and by tumor PD-L1 expression (PD-L1+: ≥5% tumor cells expressing PD-L1). Results: Objective response rate (ORR) was 21%, with 3 confirmed complete responses; 9/11 responders (82%) achieved response by first scan (wk 11). Median duration of response (mDOR) was not reached (NR; range, 7.6+, 85.6+ wks); 9 pts (82%) had ongoing responses at last tumor assessment, with a minimum follow-up of 8 mos in all pts. Two pts had unconventional immune-pattern responses with 35% and 43% maximum reductions in target lesions, respectively, and simultaneous appearance of new lesions (not reported as responders). Median overall survival (mOS) was 98.3 wks (range, 1.0, 104.4+). Objective responses were observed in both PD-L1+ and PD-L1– pts, with ORR higher in pts with PD-L1+tumors. Eight pts (15%) experienced grade 3–4 treatment-related adverse events, including rash (n=2), increased amylase/lipase, increased AST/ALT, hyperglycemia, cardiac failure, lung infection, and pneumonitis (n=1 each). Conclusions: First-line NIVO demonstrated durable responses, encouraging survival and a tolerable safety profile in pts with advanced NSCLC. Although response rates were higher in PD-L1+ pts, OS was encouraging in both PD-L1+ and PD-L1– pts. Updated OS and safety data will be presented. Clinical trial information: NCT01454102. ORR mDOR mOS n/N (%) wks (range) All pts 11/52 (21) NR (7.6+, 85.6+) 98.3 (1.0, 104.4+) Non-SQ 9/39 (23) NR (7.6+, 85.6+) NR (1.0, 104.4+) SQ 2/13 (15) NR (46.9+, 77.3+) 73.1 (13.3, 87.3+) PD-L1+ 8/26 (31) NR (7.6+, 85.6+) NR (1.0, 103.3+) PD-L1 2/21 (10) NR (13.0+, 24.1+) 98.3 (8.0, 104.4+)
Fast, accurate and versatile Monte Carlo method for computing system matrix (2007)

A new methodology is proposed to mitigate the high computation cost required to derive accurate Monte Carlo (MC) based system matrix for tomographic image reconstruction. The strategy consists of taking advantage of the symmetries between the lines of response to increase the statistics of data collected for the determination of the system matrix coefficients. By using the rotation and axial symmetries of a cylindrical camera, the number of MC generated events can be reduced substantially without affecting the matrix coefficient accuracy. Moreover, using the GATE simulator list-mode saving capabilities for storing coincidence events, single events and/or single hits with all their relevant information, the MC simulation can be performed only once and system matrices for different system configurations be derived from the same simulation. Using for example Positron emission tomography (PET), the processing of the collected MC data can be fine tuned to the imaging system characteristics by setting accordingly the time and energy blurring, the detector efficiencies, the coincidence time window width and the energy thresholds. The system matrix can also include or exclude PET events like scatters and randoms. Furthermore, the system matrix can be computed for different image grids and basis functions without requiring a new MC simulation to be performed.
Programs for Verifying Circuit Connectivity of MOS/LSI Mask Artwork (1982)

This paper describes three programs which perform connectivity rule check, logic gate recognition for logic simulation and circuit connectivity comparison. These programs have been developed for verifying circuit connectivity extracted from mask artwork. Powerful algorithms are used in these programs, including a heuristic graph comparison algorithm, to realize highly practical verification aids. Through the combined use of these programs, more cost-effective verification is possible.
Enhanced electrophosphorescence via highly efficient energy transfer from conjugated polymer (2005)

We have demonstrated that efficient green electrophosphorescence is obtained via cascade energy transfer from poly(N-vinylcarbazole) (PVK) and host fluorescent polymer to the phosphorescent iridium complex. Efficient energy transfers from PVK to fluorescent polymer and then from this host polymer to iridium complex, fac-tris[2-(2-pyridinyl-kN)[5-(2,5-dimethylphenyl)phenyl]-kC]-iridium(III) [Ir(PDPP)3], were observed in the PVK/fluorescent polymer∕Ir(PDPP)3 blend system, even though the chemical compatibility between this fluorescent polymer and Ir(PDPP)3 is very poor. The phase separation between the host polymer and Ir(PDPP)3 was restrained and highly efficient energy transfer also occurred by blending with PVK which has the good chemical compatibility with both host and guest materials. The resulting device (indium tin oxide/PEDOT/blend layer/BCP/Li:Al alloy) reaches a maximum external quantum efficiency of 8.9% and a luminous efficiency of 32cd∕A.
A generalised approach to the modulation of current source inverters (2002)

The two major DC/AC power converter topologies are the voltage source inverter (VSI) and the current source inverter (CSI). The VSI has been widely investigated for optimum operation, but the CSI has not been so well studied. A major limitation for the CSI is the availability of modulation strategies with the sophistication and performance of their VSI counterparts. This paper presents a generalised method for adapting any VSI modulation strategy to control a CSI, so that the wealth of knowledge and experience associated with VSI modulation can be immediately applied to a CSI without requiring any further analysis.
The Cornucopia of Formal-Ontological Relations (2004)

The paper presents a new method for generating typologies of formal-ontological relations. The guiding idea is that formal relations are those sorts of relations which hold between entities which are constituents of distinct ontologies. We provide examples of ontologies (in the spirit of Zemach's classic “Four Ontologies” of 1970), and show how these can be used to give a rich typology of formal relations in a way which also throws light on the opposition between threeand four-dimensionalism.
Doctoral Dissertations in Political Science: In Universities of the United States (1967)

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Effect of NaOH Molarity on the Strength and Microstructure of Natural Pozzolan-Based AAC (2018)

Alarming levels of greenhouse gas emissions has triggered change in the mode of direction of building material research. In this pursuit, alkali activated binders (AAB), synthesized by activation of industrial by products and natural materials in the presence of highly alkaline solutions, have offered viable alternative to OPC. However, there are quite a number of variables which controls the properties of these binders. Among these parameters, SS/SH ratio and molarity of sodium hydroxide solution plays a very important role in the development of these binders. Therefore, this research investigates the effect of SS/SH ratio, subsequently, molarity of SH solution on the properties of natural pozzolan based AAB. The NP was activated with sodium silicate to sodium hydroxide ratio (SS/SH) between 2.0 to 2.75. Subsequently, the molarity of SH solution was varied between 8 to 14. The development in strength was monitored on the specimens cured at 60 °C. SEM and EDS techniques were used to determine the nature of the binder formed during alkali activation. The results have shown that SS/SH ratio of 2.5 and 14 molar SH solution resulted in higher strength and finer microstructure as compared to others. Also, it was understood that there exists a suitable silica modulus of combined activator which results in higher polymerization.
Synthesis and Antimicrobial Activity of 4<i>H</i>-4-Oxoquinolizine Derivatives:  Consequences of Structural Modification at the C-8 Position (1999)

The antibacterial 4H-4-oxoquinolizines were introduced recently to overcome bacterial resistance to fluoroquinolones. They exhibit potent antibacterial activity against Gram-positive, Gram-negative, and anaerobic organisms and are highly active against some quinolone-resistant bacteria including quinolone-resistant MRSA. Preliminary studies indicated that oxoquinolizines possess distinct activity and toxicity profiles as compared with their parent quinolones. In order to develop a potent antibacterial agent with the desired spectrum of activity, good tolerability, and balanced pharmacokinetic profile, we synthesized and evaluated a series of oxoquinolizines with various substituents at the C-8 position. Most compounds tested in this study demonstrated better activity against Gram-positive bacteria than ciprofloxacin and exhibited good susceptibility against ciprofloxacin- and methicillin-resistant S. aureus. While maintaining potent in vitro activity, several compounds showed improved in vivo efficacy over ABT-719 as indicated by the mouse protection test. As an example, the oral ED(50) values for the cis-3-amino-4-methylpiperidine analogue 3ss against S. aureus NCTC 10649M, S. pneumoniae ATCC 6303, and E. coli JUHL were 0. 8, 2.0, and 1.4 mg/kg, compared to 3.0, 10.0, and 8.3 mg/kg for ABT-719. The current study revealed that the steric and electronic environment, conformation, and absolute stereochemistry of the C-8 group are very important to the antibacterial profiles. Structural modifications of the C-8 group provide a useful means to improve the antibacterial activities, physicochemical properties, and pharmacokinetic profiles. Manipulation of the C-8 group also allows us to generate analogues with the desired spectrum of activity, such as analogues that are selective against respiratory pathogens.
Integrated Sample Preparation and MALDI Mass Spectrometry on a Microfluidic Compact Disk (2003)

High-throughput microfluidic processing of protein digests integrated with matrix-assisted laser desorption/ionization (MALDI) mass spectrometry on a compact disk (CD) is described. Centrifugal force moves liquid through multiple microstructures, each containing a 10-nL reversed-phase chromatography column. The CD enables parallel preparation of 96 samples with volumes ranging from one to several microliters. The peptides in the digests are concentrated, desalted, and subsequently eluted from the columns directly into MALDI target areas (200 x 400 microm) on the CD using a solvent containing the MALDI matrix. After crystallization, the CD is inserted into the MALDI instrument for peptide mass fingerprinting and database identification at a routine sensitivity down to the 200-amol level. Detection of proteolytic peptides down to the 50-amol level is demonstrated. The success rate of the CD technology in protein identification is about twice that of the C(18) ZipTips and standard MALDI steel targets. The CDs are operated using robotics to transfer samples and reagents from microcontainers to the processing inlets on the disposable CD and spinning to control the movement of liquid through the microstructures.
Correlation between ROUGE and human evaluation of extractive meeting summaries (2008)

Automatic summarization evaluation is critical to the development of summarization systems. While ROUGE has been shown to correlate well with human evaluation for content match in text summarization, there are many characteristics in multiparty meeting domain, which may pose potential problems to ROUGE. In this paper, we carefully examine how well the ROUGE scores correlate with human evaluation for extractive meeting summarization. Our experiments show that generally the correlation is rather low, but a significantly better correlation can be obtained by accounting for several unique meeting characteristics, such as disfluencies and speaker information, especially when evaluating system-generated summaries.
Data Cleaning (2016)

Detecting and repairing dirty data is one of the perennial challenges in data analytics, and failure to do so can result in inaccurate analytics and unreliable decisions. Over the past few years, there has been a surge of interest from both industry and academia on data cleaning problems including new abstractions, interfaces, approaches for scalability, and statistical techniques. To better understand the new advances in the field, we will first present a taxonomy of the data cleaning literature in which we highlight the recent interest in techniques that use constraints, rules, or patterns to detect errors, which we call qualitative data cleaning. We will describe the state-of-the-art techniques and also highlight their limitations with a series of illustrative examples. While traditionally such approaches are distinct from quantitative approaches such as outlier detection, we also discuss recent work that casts such approaches into a statistical estimation framework including: using Machine Learning to improve the efficiency and accuracy of data cleaning and considering the effects of data cleaning on statistical analysis.
Open fitting of DSP instruments is not as simple as it may seem (2006)

In Brief A discussion of the challenges to using open fittings with digital hearing aids and a description of a new approach to the problem.
Lattice thermal conductance in nanowires at low temperatures: Breakdown and recovery of quantization (2005)

The quantization of lattice thermal conductance $g$ normalized by ${g}_{0}={\ensuremath{\pi}}^{2}{k}_{B}^{2}T∕3h$ (the universal quantum of thermal conductance) was recently predicted theoretically to take an integer value over a finite range of temperature and then observed experimentally in nanowires with catenoidal contacts. The prediction of this quantization by Rego and Kirczenow [Phys. Rev. Lett. 81, 232 (1998)] relies on a study of only dilatational (longitudinal) vibrational mode in the wires. We study the thermal conductance in catenoidal wires by explicitly calculating the transmission rates of the six distinct vibrational modes (four acoustic and two low-lying optical modes) and applying the Landauer formula for the one-dimensional thermal transport in the ballistic regime. In a temperature range similar to the one predicted by Rego and Kirczenow, we find the presence of a plateau in $g∕{g}_{0}$. However, below this temperature range $g∕{g}_{0}$ is modified---that is, the quantization is broken---due to imperfect transmission of the acoustic modes of vibration. Our new observation is that, as temperature goes down further, the recovery of the quantization of $g∕{g}_{0}$ should occur. These results are found assuming GaAs as a wire material, but we also make similar calculations for silicon nitride wires used experimentally.
A Probabilistic Approach to Pricing a Bundle of Products or Services (1993)

The authors propose a probabilistic approach to optimally price a bundle of products or services that maximizes seller's profits. Their focus is on situations in which consumer decision making is on the basis of multiple criteria. For model development and empirical investigation they consider a season ticket bundle for a series of entertainment performances such as sports games and music/dance concerts. In this case, they assume consumer purchase decisions to be a function of two independent resource dimensions, namely, available time to attend performances and reservation price per performance. Using this information, the model suggests the optimal prices of the bundle and/or components (individual performances), and corresponding maximum profits under three alternative strategies: (a) pure components (each performance is priced and offered separately), (b) pure bundling (the performances are priced and offered only as a bundle), and (c) mixed bundling (both the bundle and the individual performances are priced and offered separately). They apply their model to price a planned series of music/dance performances. Results indicate that a mixed bundling strategy is more profitable than pure components or pure bundling strategies provided the relative prices of the bundle and components are carefully chosen. Limitations and possible extensions of the model are discussed.
Hierarchical mesh-based global motion estimation, including occlusion areas detection (2002)

We present a method which is able to determine the occlusion areas appearing in a mesh-based motion estimation. The use of the motion estimation scheme based on a non-uniform hierarchical triangular mesh and the optimization of the nodal motion vectors by means of a multi-resolution differential method leads to efficient and fast motion estimation as well as motion field refinement. Although global motion estimation avoids the blocking artifacts due to the independence of the neighboring blocks of conventional block matching, it can only find the optimal motion parameters, which derive from the motion vectors at the node points that are shared by several patches of a continuous field. However real motion in a video sequence is discontinuous. Thus, our goal consists of modeling the artifacts, resulting from the occlusions by using a global mesh. Contrary to the segmented mesh associated with the video object when fast motion has to be estimated, surface mesh may contain overlapping triangles and the estimated image is thus deteriorated. In fact, these overlaps allow the detection of the occlusions. Thus, our method consists of taking into account this information to determine the optimal motion vectors in the continuous field and to generate the content of the uncovered area or to exclude the content of the covered area. To illustrate the new performances of the proposed method, results showing the capabilities of our mesh-based motion estimation to determine discontinuities lines are presented.
SEcure Neighbor Discovery (SEND) (2005)

IPv6 nodes use the Neighbor Discovery Protocol (NDP) to discover other nodes on the link, to determine their link-layer addresses to find routers, and to maintain reachability information about the paths to active neighbors.If not secured, NDP is vulnerable to various attacks.This document specifies security mechanisms for NDP.Unlike those in the original NDP specifications, these mechanisms do not use IPsec.
Incorporation of magnetite nanoparticle clusters in fluorescent silica nanoparticles for high-performance brain tumor delineation (2010)

Bifunctional nanoprobes with both magnetic and optical contrast have been developed for ultra-sensitive brain tumor imaging at the cellular level. The nanoprobes were synthesized by simultaneously incorporating a magnetite nanoparticle cluster and fluorescence dyes into silica encapsulation by a sol-gel approach under ultrasonic treatment. The nanoprobes maintain superparamagnetic behavior at room temperature and possess enhanced transverse relaxivity and good photostability. As a glioma targeting ligand, chlorotoxin was covalently bonded to the surface of the nanoprobes. In vitro cellular uptake assays demonstrated that the nanoprobes were highly specific, taken up by human U251-MG glioma cells via receptor-mediated endocytosis. The labeled glioma cells were readily detectable by both MR imager and confocal laser scanning microscopy.
Measurement of sound transmission loss by sound intensity (1985)

The sound intensity technique is being implemented to measure sound transmission loss at the Centre for Building Studies acoustics test faci1ity.The use of the intensity technique for this purpose is being investi gated in three main areas; validation with respect to standard techniques; determination of appropriate measuring procedure; exploiting the analytical capabilities of the technique.This paper presents some preliminary findings with respect to these areas. SOM M AIREDans le laboratoire d'acoustique du Centre des tudes sur le btiment, la technique de mesure de l'in ten sit acoustique est introduite afin de dterminer la transmission du son.A cet effet, l'u tilisa tio n de cette technique est examine dans les trois domaines suivants: validation par rapport aux normes, dtermination d'une procdure de mesure approprie et ^exploitation des capacits analitiques de^cette^mthode.Cet article prsente quelques conclusions p r li minaires cet gard.
Timely Addition of Glutathione for Its Interaction with Deoxypentosone To Inhibit the Aqueous Maillard Reaction and Browning of Glycylglycine–Arabinose System (2019)

The inhibitory effects of glutathione (GSH) and oxiglutathione (GSSG) on Maillard browning were compared, and it was clarified that free sulfhydryl was the key substance for the inhibition. The Amadori rearrangement product (ARP) derived from glycylglycine (Gly-Gly) and arabinose (Ara) was prepared by aqueous Maillard reaction, and LC-MS/MS was used to investigate the reaction products of GSH and purified ARP. Reaction between GSH and deoxypentosone (DP) was found to alter the pathway of aqueous Maillard reaction, which reduced the production of glyoxal, methylglyoxal, and furfural and thereby inhibited the formation of melanoidins. To determine the optimal conditions for browning inhibition, a stepwise increase of temperature was used to prepare Maillard reaction products (MRPs). The results showed that the optimum browning inhibitory effect was obtained by adding GSH after Gly-Gly and Ara heating at 80 °C for 60 min.
The Design of Web Based Car Recommendation System using Hybrid Recommender Algorithm (2018)

Web based recommendations for any item is mandatory in E-commerce based web sites. This paper is about the design of web based car recommendation system using the hybrid recommender algorithm. The proposed hybrid recommender algorithm is the combination of user-to-user and item-to-item collaborative filtering method to generate the car recommendations. The user model is designed using demographic features, click data and browsing history. Item profile is built using the various attributes of car, 40 brands of car including 224 car types are used in this work. The synthetic dataset of 300 users with 10000 sessions is used to build user model. The proposed algorithm is evaluated with 100 real time users and shows the 83% accuracy in generating recommendations.
Thin optical bonds for infrared uses (1987)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Robert R. Turtle, "Thin optical bonds for infrared uses," Appl. Opt. 26, 4346-4347 (1987) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
MODULATION OF 10.6-μ LASER RADIATION BY ULTRASONIC DIFFRACTION (1966)

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Image segmentation using Markov random field models (1998)

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