gebhart/patrepeval huggingface dataset:
Intraperitoneal injections of prostaglandin E2 attenuate hyperthermia induced by restraint or interleukin‐1 in rats. (1991)

1. The purpose of this study was to investigate the effect of the intraperitoneal (I.P.), intravenous (I.V.) or intrapreoptic area (POA) injection of prostaglandin E2 (PGE2) on the body temperature of restrained and unrestrained rats. The effect of I.P. PGE2 on the body temperature of rats during fever induced by I.P. injection of interleukin-1 beta (IL-1 beta) was also investigated. 2. Prior to injection, restrained rats had body temperatures of approximately 1 degree C higher than unrestrained rats. The I.P. injection of PGE2 (0.05 and 0.5 mg kg-1) caused body temperature to fall towards the pre-restraint levels in a dose-dependent manner. This fall in body temperature was preceded by a sharp increase in tail skin temperature that was also dependent on dose. The I.P. injection of PGE2 had no effect on the body temperature of unrestrained animals. 3. The I.V. injection of PGE2 caused very little change in the body temperature of restrained rats. However, when injected I.V. into unrestrained animals, PGE2 caused dose-dependent fevers. The injection of PGE2 (50 ng) into the POA resulted in fever in both restrained and unrestrained animals. 4. The I.P. injection of IL-1 beta (10 micrograms kg-1) caused a biphasic fever that lasted at least 420 min. The I.P. injection of PGE2 180 min after the injection of IL-1 beta caused a transient decrease in the rats' body temperature. This drop in body temperature was not associated with a decrease in metabolic rate. 5. These data support the hypothesis that during restraint stress hyperthermia and IL-1 beta fever, the I.P. injection of PGE2 acts peripherally to lower the body temperature of rats.
An application of tool insertion using model-based vision (1991)

Model-based vision is shown to be a viable solution to a tool insertion problem for the nuclear servicing industry. A complete tool insertion system requires: representation of the model, extraction of model parameters from sensor data, quantification of sensor error, transformation of sensor error to model error, sensor calibration techniques, and motion planning for sensor drop out recovery. Each of these topics is considered as a component technology and related as an aggregate system in a technical insertion scenario. While each of these technologies is required in a complete system, the specific technique is application dependent. The requisite technologies are discussed in the context of the general problem, the insertion of a four-pronged tool into four specific holes in a plane, using a vision-corrected CAD model.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Mother's prior intrauterine position affects the sex ratio of her offspring in house mice. (1994)

Sex ratio alterations related to environmental factors occur in several mammals, but no mechanism has been identified to explain the adjustment. Intrauterine position (IUP) may provide the context in which such alterations occur. Previous studies on house mice and gerbils reveal that the position of a fetus in the uterus in relation to the sex of its neighbors influences its later anatomy, physiology, and behavior. The anogenital distance (AGD) of females located between two males (2M) is longer than that of females not between two males (OM). We have found that the IUP, as determined by cesarean section and by an index of the AGD, correlates with the sex ratio of the litters produced by female mice. The sex ratio of the first litter born to 2M females was 58% males, for 1M females was 51% males and for OM females was 42% males. The effect on sex ratio continues into the second litter. The number of pups produced by mothers of different IUPs in her first two litters did not differ, suggesting that the sex ratio adjustment occurs prior to parturition. These results provide a basis for the natural variability observed in sex ratios of litter-bearing mammals and suggest that one or more intrauterine mechanisms may be responsible for environmentally related sex ratio alterations.
A bio-inspired companding strategy for spectral enhancement (2005)

This work presents a compressing-and-expanding, i.e., companding, strategy for spectral enhancement inspired by the operation of the auditory system. The companding strategy simulates the two-tone suppression phenomena of the auditory system and implements a soft local winner-take-all-like enhancement of the input spectrum. It performs multichannel syllabic compression without degrading spectral contrast. The companding strategy works in an analog fashion without explicit decision making, without the use of the fast Fourier transform, and without any cross-coupling between spectral channels. The strategy is useful in cochlear-implant processors, hearing aids, and speech recognition for enhancing spectral contrast. It is well suited to low-power analog circuit implementations.
[Immunosorption of individual HIV proteins and virions]. (1991)

Immunosorbents specifically binding native (gp160, gp120, gp41) and recombinant env proteins and HIV-I virions were synthesized on the basis of Sepharose 4B and Silica with immobilized ligands such as gamma-fraction of rabbit antiserum to HIV-I proteins and purified antibodies to env proteins of HIV-I. The possibility was shown of selective extraction of HIV-I virions and individual HIV proteins both in vitro and in vivo. The titer of virus antigens (in ELISA) after perfusion via an immunosorbent of patterns with a high content of virions and HIV-I proteins was 8 times as low as the starting titer (after perfusion via the control sorbent it was 2-fold decreased). Extracorporeal immunosorption in animals after intravenous injection of recombinant env protein permitted the latter's titer to be 5 times lower. After perfusion via the control sorbent the titer dropped by at least 20% as compared with the starting titer. The possibility of using immunosorption in multimodality therapy of AIDS is under discussion.
A Scalable and Efficient Approach for Obtaining Measurements in CAN-Based Control Systems (2008)

The availability of small inexpensive sensor elements enables the employment of large wired or wireless sensor networks for feeding control systems. Unfortunately, the need to transmit a large number of sensor measurements over a network negatively affects the timing parameters of the control loop. This paper presents a solution to this problem by representing sensor measurements with an approximate representation-an interpolation of sensor measurements as a function of space coordinates. A priority-based medium access control (MAC) protocol is used to select the sensor messages with high information content. Thus, the information from a large number of sensor measurements is conveyed within a few messages. This approach greatly reduces the time for obtaining a snapshot of the environment state and therefore supports the real-time requirements of feedback control loops.
Electrophoretic Deposition of Carbon Nanotubes over TiO<sub>2</sub>Nanotubes: Evaluation of Surface Properties and Biocompatibility (2014)

Titanium (Ti) is often used as an orthopedic and dental implant material due to its better mechanical properties, corrosion resistance, and excellent biocompatibility. Formation of TiO2 nanotubes (TiO2 NTs) on titanium is an interesting surface modification to achieve controlled drug delivery and to promote cell growth. Carbon nanotubes (CNTs) possess excellent chemical durability and mechanical strength. The use of CNTs in biomedical applications such as scaffolds has received considerable attention in recent years. The present study aims to modify the surface of titanium by anodizing to form TiO2 NTs and subsequently deposit CNTs over it by electrophoretic deposition (EPD). Characteristic, biocompatibility, and apatite forming ability of the surface modified samples were evaluated. The results of the study reveal that CNTs coating on TiO2 nanotubes help improve the biological activity and this type of surface modification is highly suitable for biomedical applications.
Plasma Deposition and Characterization of Thin Silicon‐Rich Silicon Nitride Films (1987)

Films of containing excess Si were prepared by plasma‐enhanced chemical vapor deposition at 350°C by the glow discharge reaction of gaseous (1.9% in helium) in in a tube‐type, hot wall reactor at 450 kHz RF frequency. The amount of silicon in the films was adjusted by varying the reactant gas‐phase ratio. The deposited films had a refractive index range of 1.90–2.70. Auger analysis (depth profiles) showed that the Si concentration in the films increased with refractive index. A small amount of oxygen contamination was observed on all film surfaces. X‐ray photoelectron spectroscopy measurements showed the presence of excess silicon, probably present as amorphous Si clusters in films with a high refractive index and oxygen contamination in all deposited film surfaces. Fourier transform infrared and nuclear reaction analysis for hydrogen showed that the hydrogen concentration ranged from 13 to 22 atomic percent and the hydrogen concentration decreased monotonically with increased refractive index. Etch rates of deposited films in glow discharge decrease monotonically with decreased hydrogen and increased silicon concentration in the films.
Use of Allophycocyanin Allows Quantitative Description by Flow Cytometry of Alveolar Macrophage Surface Antigens Present in Low Numbers of Cells (1988)

Autofluorescence has limited quantitative description by flow cytometry of certain alveolar macrophage surface antigens. Autofluorescence is most significant when macrophages are excited by blue light and emission is monitored in the green-yellow light range. Because of recent advances in flow cytometry and in the development of fluorescent labeling compounds, such as allophycocyanin, autofluorescence can be minimized by the use of red excitation and emission wavelengths. We have developed a three-step labeling technique that discretely identifies the minor subpopulation of normal rat alveolar macrophages that express Class II major histocompatibility (Ia) antigens. Using this technique, we observed that alveolar macrophage Ia antigen expression increases at least fourfold after intravenous administration of bacillus Calmette-Guerin to previously primed rats. Additionally, we observed that in vitro treatment of alveolar macrophages by exposure to gamma interferon results in an increase in Ia antigen expression. This new method is significant because flow cytometry is a powerful tool with which to analyze quickly, accurately, and reproducibly alveolar macrophage surface antigens.
Extraction of Astaxantine and Phycocyanine from Microalgae with Supercritical Carbon Dioxide (2003)

Astaxantine from the microalga Haematococcus pluvialis and phycocyanine from the microalga Spirulina maxima have been obtained by supercritical extraction using carbon dioxide. Prior to extraction, the samples of microalgae were crushed by cutting mills (coffee mill) and then manually ground with dry ice (solid carbon dioxide). The Haematococcus extracts were analyzed by liquid chromatography, using astaxantin (purity of 98%) as a standard. Phycocyanine, being insoluble in carbon dioxide, was indirectly separated. Thus, lipid-soluble substances from spirulina were extracted and analyzed by liquid chromatography, using as a standard a solution prepared on the base of reagent (purity of 40%). For the astaxantine extraction, the results show that cellular wall breaking has an important effect on extraction efficiency. The addition of a cosolvent (9.4 mass % of ethanol) has little effect, reaching an extraction yield of about 1.7 mass %. The extraction yield is much below the expected lipid content in dry Haematococcus alga samples, which is known to be close to 30 mass %. The maximum total recovery of astaxantin, calculated from its initial and residual content in the alga (0.0147 and 0.0004, respectively), exceeds 97%. For phycocyanine extraction, the addition of cosolvent (10 mass % of ethanol) has a strong effect on the extraction yield of lipidic substances. This value goes from about 1.1% for extraction without cosolvent to about 1.7 mass % when the cosolvent is used. The total extraction yield of about 3 mass % corresponds well to the average lipid content of 3.27% in alga Spirulina maxima reported in the literature.
Using Local Affine Invariants to Improve Image Matching (2010)

A method to classify tentative feature matches as inliers or outliers to a transformation model is presented. It is well known that ratios of areas of corresponding shapes are affine invariants. Our algorithm uses consistency of ratios of areas in pairs of images to classify matches as inliers or outliers. The method selects four matches within a region, and generates all possible corresponding triangles. All matches are classified as inliers or outliers based on the variance among the ratio of areas of the triangles. The selected inliers are used to compute a homography transformation. We present experimental results showing significant improvements over the baseline RANSAC algorithm for pairs of images from the Zurich Building Database.
Methyl aryl ether cleavage in benzazole syntheses in polyphosphoric acid (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMethyl aryl ether cleavage in benzazole syntheses in polyphosphoric acidCharles M. Orlando Jr., J. G. Wirth, and D. R. HeathCite this: J. Org. Chem. 1970, 35, 9, 3147–3149Publication Date (Print):September 1, 1970Publication History Published online1 May 2002Published inissue 1 September 1970https://pubs.acs.org/doi/10.1021/jo00834a065https://doi.org/10.1021/jo00834a065research-articleACS PublicationsRequest reuse permissionsArticle Views419Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Duplication of CaMV 35 <i>S</i> Promoter Sequences Creates a Strong Enhancer for Plant Genes (1987)

A variant of the cauliflower mosaic virus 35S promoter with transcriptional activity approximately tenfold higher than that of the natural promoter was constructed by tandem duplication of 250 base pairs of upstream sequences. The duplicated region also acted as a strong enhancer of heterologous promoters, increasing the activity of an adjacent and divergently transcribed transferred DNA gene several hundredfold, and to a lesser extent, that of another transferred DNA gene from a remote downstream position. This optimized enhancer element should be very useful for obtaining high levels of expression of foreign genes in transgenic plants.
Principles of an enhanced MBR-process with mechanical cleaning (2011)

Up to date, different physical and chemical cleaning protocols are necessary to limit membrane fouling in membrane bioreactors. This paper deals with a mechanical cleaning process, which aims at the avoidance of hypochlorite and other critical chemicals in MBR with submerged flat sheet modules. The process basically consists of the addition of plastic particles into the loop circulation within submerged membrane modules. Investigations of two pilot plants are presented: Pilot plant 1 is equipped with a 10 m(2) membrane module and operated with a translucent model suspension; pilot plant 2 is equipped with four 50 m(2) membrane modules and operated with pretreated sewage. Results of pilot plant 1 show that the establishment of a fluidised bed with regular particle distribution is possible for a variety of particles. Particles with maximum densities of 1.05 g/cm(3) and between 3 and 5 mm diameter form a stable fluidised bed almost regardless of activated sludge concentration, viscosity and reactor geometry. Particles with densities between 1.05 g/cm(3) and 1.2 g/cm(3) form a stable fluidised bed, if the velocity at the reactor bottom is sufficiently high. Activities within pilot plant 2 focused on plant optimisation and the development of an adequate particle retention system.
Assembly with the NR1 Subunit Is Required for Surface Expression of NR3A-Containing NMDA Receptors (2001)

Functional NMDA receptors are heteromultimeric complexes of the NR1 subunit in combination with at least one of the four NR2 subunits (A-D). Coexpression of NR3A, an additional subunit of the NMDA receptor family, modifies NMDA-mediated responses. It is unclear whether NR3A interacts directly with NR1 and/or NR2 subunits and how such association might regulate the intracellular trafficking and membrane expression of NR3A. Here we show that NR3A coassembles with NR1-1a and NR2A to form a receptor complex with distinct single-channel properties and a reduced relative calcium permeability. NR3A associates independently with both NR1-1a and NR2A in the endoplasmic reticulum, but only heteromeric complexes containing the NR1-1a NMDA receptor subunit are targeted to the plasma membrane. Homomeric NR3A complexes or complexes composed of NR2A and NR3A were not detected on the cell surface and are retained in the endoplasmic reticulum. Coexpression of NR1-1a facilitates the surface expression of NR3A-containing receptors, reduces the accumulation of NR3A subunits in the endoplasmic reticulum, and induces the appearance of intracellular clusters where both subunits are colocalized. Our data demonstrate a role for subunit oligomerization and specifically assembly with the NR1 subunit in the trafficking and plasma membrane targeting of the receptor complex.
Transduction of Human CD34+CD38- Bone Marrow and Cord Blood-Derived SCID-Repopulating Cells with Third-Generation Lentiviral Vectors (2000)

The major limitations of Moloney murine leukemia virus (MoMLV)-based vectors for human stem cell applications, particularly those requiring bone marrow (BM) stem cells, include their requirement for mitosis and retroviral receptor expression. New vectors based upon lentiviruses such as HIV-1 exhibit properties that may circumvent these problems. We report that novel third-generation, self-inactivating lentiviral vectors, expressing enhanced green fluorescent protein (EGFP) and pseudotyped with vesicular stomatitis virus G glycoprotein (VSV-G), can efficiently transduce primitive human repopulating cells derived from human BM and cord blood (CB) tested by the SCID-repopulating cell (SRC) assay. Highly purified CD34+ CD38- CB or BM cells were efficiently transduced (4-69%) and stably expressed in EGFP for 40 days in culture following infection for only 24 h without fibronectin, polybrene, or cytokines. Nonobese diabetic/severe combined immune-deficient (NOD/SCID) mice transplanted with transduced cells from either CB or BM donors were well engrafted, demonstrating maintenance of SRC during the infection procedure. Serially obtained femoral BM samples indicated that the proportion of EGFP+ cells within both myeloid and lymphoid lineages was maintained or even increased over time, averaging 42.3 +/- 6.6% for BM donors and 23.3 +/- 7.2% for CB at 12 weeks. Thus, the third-generation lentivectors readily transduce human CB and BM stem cells, under minimal conditions of ex vivo culture, where MoMLV-based vectors are ineffective. Since CB is inappropriate for most therapeutic applications, the efficient maintenance and transduction of BM-derived SRC during the short infection procedure are notable advantages of lentivectors.
The direct synthesis of sulfobetaine-containing amphiphilic block copolymers and their self-assembly behavior (2016)

a b s t r a c t Diblock copolymers containing the thermo-responsive sulfobetaine, [2-(methacryloyloxy) ethyl] dimethyl-(3-sulfopropyl) ammonium hydroxide (DMAPS), were synthesized by the aqueous RAFT polymerization of DMAPS, followed by direct chain extension in hexafluoroisopropanol (HFIP) with methyl methacrylate (MMA). This was shown to give lower dispersity polymers than RAFT emulsion polymerization. The diblock copolymers selfassembled in water to form micelles, as analyzed by light scattering (LS) and transmission electron microscopy (TEM). Micelles formed from diblocks bearing a long PDMAPS block were shown to swell with temperature, rather than display a traditional UCST cloud point. This was due to the polymers retaining hydrophilicity, even at temperatures well below the UCST for the corresponding PDMAPS homopolymer, as shown by variable temperature NMR. This swelling behavior was utilized in the release of a hydrophobic dye in response to temperature. This approach has great potential for applications in controlled release whilst maintaining the structure of the carrier nanoparticles.
Urinary and brain beta-carboline-3-carboxylates as potent inhibitors of brain benzodiazepine receptors. (1980)

Benzodiazepines probably exert their anxiolytic, hypnotic, and anticonvulsant effects by interacting with brain-specific high-affinity benzodiazepine receptors. In searching for possible endogenous ligands for these receptors we have purified a compound 10(7)-fold from human urine by extractions, treatment with hot ethanol, and column chromatography. The compound was identified as beta-carboline-3-carboxylic acid ethyl ester (IIc) by mass spectrometry, NMR spectrometry, and synthesis; IIc was also isolated from brain tissues (20 ng/g) by similar procedures. Very small concentrations of IIc displaced [3H]diazepam completely from specific cerebral receptors, but not from liver and kidney binding sites; the concentration causing 50% inhibition of specific [3H]diazepam binding (IC50) was 4-7 nM compared to ca. 5 nM for the potent benzodiazepine lorazepam. Specific binding sites for quinuclidinyl benzilate, naloxone, spiroperidol, serotonin, muscimol, and WB 4101 were not affected by IIc. In contrast to benzodiazepines, IIc exhibits "mixed type" competitive inhibition of forebrain benzodiazepine receptors (negative cooperativity). We surmise that an endogenous ligand for benzodiazepine receptors may be a derivative of beta-carboline-3-carboxylic acid.
Alcohol and the liver: metabolism of alcohol and its role in hepatic and extrahepatic diseases. (2000)

The research of Dr. Lieber and his group yielded a better understanding of the pathogenesis of common hepatic, gastric and nutritional disorders, with elucidation and prevention of serious toxic alcohol-drug interactions and the development of methods for early recognition and more effective approaches to prevent and treat liver and gastrointestinal diseases.
A study of post-chemical-mechanical polish cleaning strategies (2002)

Chemical-mechanical polishing (CMP) has emerged as the premier technique for achieving both local and global planarization. One of the primary concerns in the use of CMP, however, is the efficient and complete removal of CMP contaminants such as slurry and residual hydrocarbons. This paper discusses the removal of silica-based slurries utilized for polysilicon and oxide CMP processes. The effects of mechanical brush cleaning, chemical treatments, and polish processes on defect density for a 16 Mb memory technology are presented. In addition, the chemical compatibility of polishing slurries with various brush and polishing pad materials is discussed.