gebhart/patrepeval huggingface dataset:
Induction of peripheral-type benzodiazepine receptors during differentiation of mouse erythroleukemia cells. A possible involvement of these receptors in heme biosynthesis. (1994)

To search for a possible role for peripheral-type benzodiazepine receptors (PBR) during erythroid differentiation, we cloned the PBR isoquinoline carboxamide-binding protein (PBR/IBP), an 18-kDa protein on PBR, from a mouse erythroleukemia (MEL) cell cDNA library. Sequence analysis revealed that PBR/IBP comprises 169 amino acid residues (M(r) 18,828), and has a high homology with PBR/IBP from other sources. The cDNA allows for the expression of active PBR/IBP, exhibiting a high affinity for isoquinoline carboxamide, [3H]PK11195, with Kd of 0.80 and 1.56 nM. RNA blot analysis revealed that treatment of MEL cells with dimethyl sulfoxide led to an increase in PBR/IBP mRNA (delta 1.0 kilobases) for up to 72 h, with a concomitant induction of mRNAs for heme biosynthetic enzymes, coproporphyrinogen oxidase and ferrochelatase. The induction of PBR/IBP mRNA was also observed in MEL cells induced with diazepam. The binding activity of [3H]PK11195 in MEL cells showed a high affinity with Kd of 0.69-2.13 nM, and increased during erythroid differentiation. The order of potency of different ligands to compete against [3H]PK11195 binding in induced MEL cells was PK11195 > protoporphyrin IX > diazepam > coproporphyrinogen III > coproporphyrin III > estazolam. In contrast to the induction of PBR/IBP in induced MEL cells, the voltage-dependent anion channel (mitochondrial porin) associated with PBR remained unchanged. These results suggest that PBR/IBP on PBR may be involved in porphyrin transport and may even be a critical factor in erythroid-specific induction of heme biosynthesis.
Immunosorbent Assay Based on Recombinant Hemagglutinin Protein Produced in a High-Efficiency Mammalian Expression System for Surveillance of Measles Immunity (1998)

Recombinant hemagglutinin (H) protein of the measles virus (MV) was produced in mammalian cells with a high-yield expression system based on the Semliki Forest virus replicon. Crude membrane preparations of H protein-transfected BHK-21 cells were used to coat microtiter plates to measure specific immunoglobulin G antibodies in 228 serologically defined serum samples mainly from measles late-convalescent adults. The titers by the enzyme-linked immunosorbent assay for the H protein (H-ELISA) closely correlated with neutralization test (NT) titers (R2 = 0.66), hemagglutination inhibition test (HI) titers (R2 = 0.64), with the titers from a certified commercial ELISA based on whole MV-infected cells (MV-ELISA; R2 = 0.45). The correlations described above were better than those of the commercial MV-ELISA titers with the NT (R2 = 0.52) or HI (R2 = 0.48) titers. By using the 2nd International Standard for anti-measles serum, the detection level of the assay corresponds to 215 mIU/ml for undiluted serum, which corresponds to the estimated threshold for protective immunity. The specificity, accuracy, and positive predictive value were, in general, better for the H-ELISA than for a commercial MV-ELISA, independent of whether HI, NT, or HI and NT were used as "gold standards." In contrast, the H-ELISA proved to be slightly less sensitive than the MV-ELISA (sensitivities, 98.6 versus 99.5%, respectively; P was not significant). The assays did not differ significantly in the number of serum samples with positive HI and NT results (n = 212) which measured false negative (H-ELISA, 2 of 212 [0.94%]; MV-ELISA, 1 of 212 [0.47%]), but the H-ELISA detected significantly more measles-susceptible individuals than the MV-ELISA (10 of 11 versus 3 of 11, respectively; P < 0.05) among the individuals whose sera had negative HI and NT results. Our data demonstrate that the H-protein preparation that we describe could be a cost-effective alternative to current whole-virus-based ELISAs for surveillance for immunity to measles and that such an assay could be more efficient in detecting susceptibility to measles. Furthermore, unlike whole MV-based antigens, H-protein would also be suitable for use in the development of a simple field test for the diagnosis of measles.
Kinetics of lipid oxidation in foods (1971)

Abstract This review shows how the basic kinetics of lipid oxidation can be simplified for application to the study of food deterioration. The physical and chemical factors that control oxidation are examined and analyzed in terms of food structure and composition. Studies of oxidation of several food items are examined in light of these kinetics and mechanisms.
Cancer immunotherapy (2016)

Immunotherapy has changed the treatment of urologic malignancies. New immunotherapies and novel combinations will continue to create new treatment options in urologic tumors.
Shared aperture dual band dual polarization microstrip patch antenna (2013)

Abstract This article presents the design and development of a new type of wideband shared aperture dual band dual microstrip polarization patch antenna (MPA) operating at L&S band. In this configuration, square ring shaped radiating element at L band and square shaped patch printed on different dielectric substrate layers housed within the square ring at S‐band has been used. The probe fed feeding mechanism is employed to get wide bandwidth performance at both bands. The measured 10‐dB return loss bandwidth is 28.3% at L band and 29.4% at S‐band. The simulated and measured antenna parameters of this antenna are in excellent agreement. © 2012 Wiley Periodicals, Inc. Microwave Opt Technol Lett 55:917–922, 2013; View this article online at wileyonlinelibrary.com. DOI: 10.1002/mop.27414
Regulation of G Protein-Coupled Receptor Signaling by A-Kinase Anchoring Proteins (2006)

Specificity of transduction events is controlled at the molecular level by scaffold, anchoring, and adaptor proteins, which position signaling enzymes at proper subcellular localization. This allows their efficient catalytic activation and accurate substrate selection. A-kinase anchoring proteins (AKAPs) are group of functionally related proteins that compartmentalize the cAMP-dependent protein kinase (PKA) and other signaling enyzmes at precise subcellular sites in close proximity to their physiological substrate(s) and favor specific phosphorylation events. Recent evidence suggests that AKAP transduction complexes play a key role in regulating G protein-coupled receptor (GPCR) signaling. Regulation can occur at multiple levels because AKAPs have been shown both to directly modulate GPCR function and to act as downstream effectors of GPCR signaling. In this minireview, we focus on the molecular mechanisms through which AKAP-signaling complexes modulate GPCR transduction cascades.
가정용 총정맥영양의 경제성 평가 (2016)

The restricted resources on healthcare highlights the importance of clinical and cost effectiveness. The social and economic costs of chronic diseases are increasing. Home total parenteral nutrition (home TPN) for the patients with intestinal failure is a life-sustaining therapy until intestinal transplantation. An economic evaluation of home TPN has not been conducted in Korea. Three types of economic evaluations for home TPN are cost benefit analysis, cost effectiveness analysis, and cost utility analysis. Korea``s medical market is competitive due to the limited health care resources. A health care delivery system from hospital to home needs to be established under the supervision of professional Nutrition Support Team staff including the systematic policies and social recognition.
Direct Synthesis of Cyclodextrin-Rotaxanated Poly(ethylene glycol)s and Their Self-Diffusion Behavior in Dilute Solution (2003)

Poly[(ethylene glycol)-rotaxa-(α-cyclodextrin)]s, (PEG-rotaxa-αCD)s, were prepared by a direct route from commercially available poly(ethylene glycol)s (PEG) with molecular weights from 1.5 to 20 kg/mol. The rotaxanated structure was verified by diffusion-ordered 2D NMR spectroscopy (DOSY). The self-diffusion coefficients for PEG-rotaxa-αCD and PEG in dilute DMSO-d6 scale with their respective molecular weights as DPEG-rotaxa-αCD ∼ Mn-0.60±0.05 and DPEG ∼ Mn-0.55±0.03. With increasing temperature, the hydrodynamic radius of the PEG-rotaxa-αCD increases by the same slope as the unthreaded PEG backbone. These polyrotaxanes, in which up to 70% of the backbone is covered with cyclodextrins, behave as random coils in good solvents.
Adsorption of Proteins to Hydrophobic Sites on Mixed Self-Assembled Monolayers (2003)

This paper describes a technique that uses mixed self-assembled monolayers of two alkanethiolates (-S(CH2)11(OCH2CH2)6OR, R = a hydrophobic group, and -S(CH2)11(OCH2CH2)nOH, n = 3, 6, EGnOH), in combination with surface plasmon resonance spectroscopy, to study the influence of the size and shape of R, and its density at the surface, on the hydrophobic adsorption of proteins at solid−liquid interfaces. Detailed results were obtained for β-galactosidase, carbonic anhydrase, lysozyme, and RNase A using R = C(C6H5)3, CH(C6H5)2, and CH2(C6H5). A hard-sphere model is used to rationalize the adsorption; this model, although very approximate, helps to interpret qualitative trends in the data. Using this model, the extent to which adsorbed proteins undergo conformational rearrangements appears to depend on the density of the hydrophobic groups at the surface and on the concentration of protein in solution. This paper describes the first step toward the development of a system that will allow the study of hydrophobic interactions of proteins with surfaces presenting organic groups of well-defined shape.
THE ANGULAR DISTRIBUTION OF PHOTOFISSION FRAGMENTS (1959)

Angular distributions of photofission fragments relative to the photon beam have been measured as a function of maximum bremsstrahlung energy in the range 6–20 Mev. The nuclides U-233, U-235, Np-237, Pu-239, and Am-241 give an isotropic distribution at all energies studied. The nuclides Th-232, U-234, U-236, U-238, and Pu-240 give anisotropic distributions which can be described by an equation of the form W(θ) = 1 + α sin 2 θ where θ is the angle between fragment and beam. The degree of anisotropy is large at low energy and falls rapidly as the energy is increased. At a given energy Th-232 has the greatest degree of anisotropy and Pu-240 the least.
Metformin Disrupts Crosstalk between G Protein–Coupled Receptor and Insulin Receptor Signaling Systems and Inhibits Pancreatic Cancer Growth (2009)

Recently, we identified a novel crosstalk between insulin and G protein-coupled receptor (GPCR) signaling pathways in human pancreatic cancer cells. Insulin enhanced GPCR signaling through a rapamycin-sensitive mTOR-dependent pathway. Metformin, the most widely used drug in the treatment of type 2 diabetes, activates AMP kinase (AMPK), which negatively regulates mTOR. Here, we determined whether metformin disrupts the crosstalk between insulin receptor and GPCR signaling in pancreatic cancer cells. Treatment of human pancreatic cancer cells (PANC-1, MIAPaCa-2, and BxPC-3) with insulin (10 ng/mL) for 5 minutes markedly enhanced the increase in intracellular [Ca(2+)] induced by GPCR agonists (e.g., neurotensin, bradykinin, and angiotensin II). Metformin pretreatment completely abrogated insulin-induced potentiation of Ca(2+) signaling but did not interfere with the effect of GPCR agonists alone. Insulin also enhanced GPCR agonist-induced growth, measured by DNA synthesis, and the number of cells cultured in adherent or nonadherent conditions. Low doses of metformin (0.1-0.5 mmol/L) blocked the stimulation of DNA synthesis, and the anchorage-dependent and anchorage-independent growth induced by insulin and GPCR agonists. Treatment with metformin induced striking and sustained increase in the phosphorylation of AMPK at Thr(172) and a selective AMPK inhibitor (compound C, at 5 micromol/L) reversed the effects of metformin on [Ca(2+)](i) and DNA synthesis, indicating that metformin acts through AMPK activation. In view of these results, we tested whether metformin inhibits pancreatic cancer growth. Administration of metformin significantly decreased the growth of MIAPaCa-2 and PANC-1 cells xenografted on the flank of nude mice. These results raise the possibility that metformin could be a potential candidate in novel treatment strategies for human pancreatic cancer.
Online Product Opinions: Incidence, Evaluation, and Evolution (2011)

Whereas recent research has demonstrated the impact of online product ratings and reviews on product sales, we still have a limited understanding of the individual's decision to contribute these opinions. In this research, we empirically model the individual's decision to provide a product rating and investigate factors that influence this decision. Specifically, we consider how previously posted ratings may affect an individual's posting behavior in terms of whether to contribute (incidence) and what to contribute (evaluation), and we identify selection effects that influence the incidence decision and adjustment effects that influence the evaluation decision. Across individuals, our results show that positive ratings environments increase posting incidence, whereas negative ratings environments discourage posting. Our results also indicate important differences across individuals in how they respond to previously posted ratings, with less frequent posters exhibiting bandwagon behavior and more active customers revealing differentiation behavior. These dynamics affect the evolution of online product opinions. Through simulations, we illustrate how the evolution of posted product opinions is shaped by the underlying customer base and show that customer bases with the same median opinion may evolve in substantially different ways because of the presence of a core group of “activists” posting increasingly negative opinions.
Breathinglike phonon modes of multiwalled carbon nanotubes (2002)

The breathinglike phonon modes of multiwalled carbon nanotubes are studied within a valence force field model for nanotubes with two and three layers of armchair type and within a continuum model for nanotubes with a large number of layers. A bond-polarizability model is used to calculate the nonresonant Raman intensity of the breathinglike modes. It is obtained that among all breathinglike modes of a given multiwalled tube, the in-phase one has a maximal intensity. The predicted intensity of the breathinglike modes is compared to available low-frequency experimental Raman data. Special attention is given to the comparison with Raman data on double-walled carbon nanotubes.
THE FUTURE of manufacturing with OPTICAL MICROLITHOGRAPHY (1990)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Colin W. T. Knight, "THE FUTURE of manufacturing with OPTICAL MICROLITHOGRAPHY," Optics & Photonics News 1(10), 11-17 (1990) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Peripheries and interfaces: the Western impact on other music (2004)

The theme of this chapter is the encounter with Western musics of other peoples during the past one hundred years. Often only occasional and sporadic at the start of the twentieth century, contact with the music of elsewhere was by the end of that century part of the everyday lives of huge numbers of people worldwide (as much within as outside the Western world). The history of this shift might be written in several ways. From a technological perspective we would discuss the invention of sound recording and broadcasting, for instance, and the dissemination of music notation and certain instruments, including the piano, guitar, accordion, and microphone. As historians of inter-cultural politics, we might instead emphasize the widespread creation through cross-cultural interaction of new genres and ensembles based in some form or other on the emulation of people seen as privileged. An ethnographic approach would look at the changing role of music in the lives of certain individuals, drawing on their own accounts of music-related events as well as on observation of and participation in some of that music-making. Meanwhile, taking the study of social institutions as a starting point, our review of the century would find common ground in the creation in many nations of music-making bodies, including orchestras of revised folk instruments, ministries of culture, competitions and festivals, bodies that regulate copyright, and colleges where music theory and performance are imparted to generations of would-be professionals; from this perspective, a key characteristic of music history in the twentieth century has been the application of similar processes to the organization of music around much of the world, providing, in some cases, pressures that result in the transformation of the musics themselves.
Microseisms in geothermal exploration; studies in Grass Valley, Nevada (1979)

Abstract Frequency(f)-wavenumber(k) spectra of seismic noise in the bands 1 &lt; or = f &lt; or = 10 Hz in frequency and k &lt; or = 35.7 cycles/km in wavenumber, measured at several places in Grass Valley, Nevada, exhibit numerous features which can be correlated with variations in surface geology and sources associated with hot spring activity. Exploration techniques for geothermal reservoirs, based upon the spatial distribution of the amplitude and frequency characteristics of short-period seismic noise, are applied and evaluated in a field program at this potential geothermal area.A detailed investigation of the spatial and temporal characteristics of the noise field was made to guide subsequent data acquisition and processing. Contour maps of normalized noise level derived from judiciously sampled data are dominated by the hot spring noise source and the generally high noise levels outlining the regions of thick alluvium. Major faults are evident when they produce a shallow lateral contrast in rock properties. Conventional seismic noise mapping techniques cannot differentiate noise anomalies due to buried seismic sources from those due to shallow geologic effects. The noise radiating from a deep reservoir ought to be evident as body waves of high-phase velocity with time-invariant source azimuth. A small two-dimensional (2-D) array was placed at 16 locations in the region to map propagation parameters. The f-k spectra reveal shallow local sources, but no evidence for a significant body wave component in the noise field was found.With proper data sampling, array processing provides a powerful method for mapping the horizontal component of the vector wavenumber of the noise field. This information, along with the accurate velocity structure, will allow ray tracing to locate a source region of radiating microseisms. In Grass Valley, and probably in most areas of sedimentary cover, the 2-10 Hz microseismic field is predominantly fundamental-mode Rayleigh waves controlled by the very shallow structure.
The Peacock putsch (1989)

The peacock putsch was caused by the CVPs: Compelled Voters' Preferences. At every Australian election, a substantial number of voters go to the polling booths because they are compelled by law. The figure probably varies between 20 and 35 per cent, depending on the issues and the drama of the personalities on public display.
MPEG-2 video transmission using the HIPERLAN/2 WLAN standard (2002)

At present, wireless local area networks (WLANs) supporting broadband multimedia communication are being developed and standardised. These will provide data rates up to 54 Mbps in the 5 GHz band. Highly compressed data such as video are extremely sensitive to the errors that are commonly encountered in wireless channels. This paper addresses the problems of transmitting MPEG-2 video over WLANs, and in particular HIPERLAN/2, and describes error resilient video transcoding as a means of handling channel errors.
Modeling and analysis of engaging process of automated mechanical transmissions (2015)

In automated mechanical transmissions, engaging sleeve with clutch gear causes the switches of mechanical coupling modes of engaging-related parts, and impacts may happen to make the part speeds have discrete transitions during the engaging. The two characters make the engaging process exhibit both continuity and discreteness. The aim of the paper is to develop a high-fidelity model to capture the trajectories of the parts in the transmission. We treat the engaging as a two-phase process-sleeve first interacting with synchro ring and then with clutch gear. The part movements under a certain constraint are governed by multibody dynamics, and the speed jumps caused by impacts are described using the Poisson coefficient of restitution. To couple the continuous evolutions and discrete transitions of the states, a hybrid automaton model is developed. This model allows for the characteristic analysis of the engaging process with multiple interaction cases between the engaging-related parts, and it is validated by bench tests. The effects of two key factors-the relative tooth position of sleeve and clutch gear and the shifting force-on engaging duration and impact are studied through numerical simulations.
SELF-HEALING OF METAL OXIDE COMPOSITE MATERIALS (2007)

A permeation barrier system that could self-heal upon the influx of moisture through defects and subsequently seal the cracks would find potential applications in multilayer composite materials. Nanoporous polylactic acid (PLA) spheres and fibers were prepared by electrospraying and electrospinning respectively. The porous spheres and fibers were exposed to titanium (IV) chloride to introduce the metal oxide precursor into the pores and subsequently seal by annealing and solvent treatment.
The electrochemical reductive trimethylsilylation of aryl chlorides: a good route to aryltrimethylsilanes and a novel route to tris(trimethylsilyl)cyclohexadienes (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe electrochemical reductive trimethylsilylation of aryl chlorides: a good route to aryltrimethylsilanes and a novel route to tris(trimethylsilyl)cyclohexadienesMichel Bordeau, Claude Biran, Pierrette Pons, Marie Pierre Leger-Lambert, and Jacques DunoguesCite this: J. Org. Chem. 1992, 57, 17, 4705–4711Publication Date (Print):August 1, 1992Publication History Published online1 May 2002Published inissue 1 August 1992https://pubs.acs.org/doi/10.1021/jo00043a031https://doi.org/10.1021/jo00043a031research-articleACS PublicationsRequest reuse permissionsArticle Views1017Altmetric-Citations39LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Widely Tunable Laser Transmitter with Fast, Accurate Switching Between All Channel Combinations (2002)

We demonstrate widely tunable laser transmitters that can access 32 ITU channels with 100 GHz spacing and accurately switch between all channel combinations in less than 50 ns. The compact modules use commercially available components. We also show the correlation of switching times to laser tuning currents
Toward effective conversational messaging (1995)

Thesis (M.S.)--Massachusetts Institute of Technology, Program in Media Arts & Sciences, 1995.