gebhart/patrepeval huggingface dataset:
Vaccination of shrimp (Penaeus chinensis) against white spot syndrome virus (WSSV). (2008)

Two structural protein genes, VP19 and VP466, of white spot syndrome virus (WSSV) were cloned and expressed in Sf21 insect cells using a baculovirus expression system for the development of injection and oral feeding vaccines against WSSV for shrimps. The cumulative mortalities of the shrimps vaccinated by the injection of rVP19 and rVP466 at 15 days after the challenge with WSSV were 50.2% and 51.8%, respectively. For the vaccination by oral feeding of rVP19 and rVP466, the cumulative mortalities were 49.2% and 89.2%, respectively. These results show that protection against WSSV can be generated in the shrimp, using the viral structural protein as a protein vaccine.
Diphasic Electrolysis Process Modelling for a Vertical Electrode (2005)

Keywords: Bubble evolution ; Anode effect ; Cathode effect ; Electrochemical discharges ; [SACE] Reference LSRO-CONF-2006-045 Record created on 2006-06-09, modified on 2010-04-10
Oxidation and Cataract (1984)

Previous work has established that oxidation of the constituents of the human lens is an early event in the development of cataract. In old pre-cataractous lenses, oxidation of the fibre membrane polypeptides is observed. Non-disulphide-linked aggregates possibly generated by photo-oxidation are also found. With the development of cataract the oxidation becomes more extensive, affecting many of the proteins of the tissue. High molecular weight, disulphide-linked aggregates are formed, involving cytosol and membrane components. Membrane rupture accompanies the process. Hydrogen peroxide has been found in elevated levels in the aqueous fluid of some cataract patients. H2O2 will cause cataract and has been shown to affect Na+,K+-ATPase. Analyses of available data suggest that (1) oxidation of membrane components may be an initiating event in cataract, and (2) the oxidizing agent may come from the exterior environment of the tissue. The problems involved in proving this hypothesis are discussed and an approach to testing the hypothesis is suggested.
CR rates in relapsed/refractory (R/R) aggressive B-NHL treated with the CD19-directed CAR T-cell product JCAR017 (TRANSCEND NHL 001). (2017)

7513 Background: JCAR017 is a second-generation, CD19-directed, 4-1BB CAR T cell product comprising CD8 and CD4 CAR T cells in a 1:1 ratio. A multicenter phase 1 trial of JCAR017 in R/R B-cell NHL (NCT02631044) is underway. Methods: Patients with R/R DLBCL, PMBCL, FL grade 3B, or MCL and adequate organ function are eligible. There was no minimum ALC requirement for apheresis; no test expansion was required. Treatment includes lymphodepletion with fludarabine and cyclophosphamide, followed by JCAR017. Multiple dose levels (DLs)/administration schedules of JCAR017 are being evaluated. Study objectives include safety, PK, and antitumor response. Results: As of November 23, 2016, 28 patients have been treated and are evaluable for safety and efficacy. Nineteen were male, 9 female; 25 DLBCL, 2 MCL, and 1 FL grade 3B. Median age was 63 years (range 37-79), median number of prior therapies was 4 (range 1-8), 23 (82%) were refractory to their last chemotherapy, and 16 (57%) had prior transplant. No severe cytokine release syndrome (sCRS) was observed; 10 patients had grade 1-2 CRS (1 received tocilizumab). Five patients developed neurotoxicity, including 4 grade 3-4; all events resolved in the 4 patients who had adequate follow up. Median onset of CRS and neurotoxicity were 5 and 11 days, respectively. Four deaths after disease progression occurred, none related to JCAR017. In 20 patients treated at DL1 (5×10 7 cells), the RR was 80% with 60% achieving CR. One patient with secondary CNS involvement achieved CR without neurotoxicity. JCAR017 was detected at 3 and 6 months in responding patients, including some who relapsed; higher mean peak levels were detected in patients with durable response at 3 months. Data on patients treated at DL2 (1×10 8 cells), alternative dose schedules, tumor biopsy, and additional biomarkers will be presented. Conclusions: Treatment with JCAR017 results in high CR rate in patients with heavily pretreated R/R DLBCL. Relapses can occur despite persistence of JCAR017, suggesting tumor immune evasion mechanisms may contribute to relapse. Observed toxicities are manageable and occurred at rates lower than those reported for other CD19-directed CAR T cell products. Clinical trial information: NCT02631044.
RAPID AND SENSITIVE OPTICAL ROTATION MEASUREMENT: KINETICS OF CONFORMATIONAL CHANGE OF RHODOPSIN INTERMEDIATE (1979)

Abstract— A rapid and sensitive optical rotation (OR) measurement system using laser light has been developed to meet the demands of flash‐photolysis experiments. The optimal OR resolution of the apparatus is 0.3mdeg with 10 μs time constant with single shot. The OR resolution could be easily improved less than 0.1 mdeg with accumulation of data by a kinetic processor. Applications are briefly described for the study of transient conformational change of photochemical intermediates of octopus rhodopsin following a blue light flash.
Acetyl-CoA-dependent pyruvate carboxylase from the photosynthetic bacterium Rhodobacter capsulatus: rapid and efficient purification using dye-ligand affinity chromatography (1995)

Pyruvate carboxylase (PC) was purified to homogeneity from an overexpressing strain of the purple photosynthetic bacterium Rhodobacter capsulatus using a rapid dye-ligand affinity chromatography procedure, in which dye-bound enzyme was specifically eluted with a low concentration of acetyl-CoA, an allosteric activator of the enzyme. The enzyme purified by this method was obtained in 75% yield with a specific activity of 40 U (mg protein)-1. In contrast, affinity chromatography on a monomeric avidin column, commonly used in the purification of biotin-containing carboxylases, resulted in a yield of < 40%, with a specific activity of 10 U (mg protein)-1. The enzyme purified by the dye-linked procedure had a subunit molecular mass of 140,000 Da and was absolutely dependent on acetyl-CoA for activity. Acetyl-CoA was also effective in protecting the enzyme from thermal denaturation. The enzyme was inhibited by 2-oxoglutarate and, to a lesser extent, L-aspartate, with sigmoidal kinetics with respect to acetyl-CoA concentration. The amino acid composition, pH optimum and kinetic constants for pyruvate, ATP and bicarbonate were determined. An N-terminal sequence of 26 residues was obtained, which was homologous to the N-terminal regions of several eukaryotic PCs, propionyl-CoA carboxylases and acetyl-CoA carboxylase.
Adsorption of colloidal particles to curved interfaces (2006)

As a simple model for a Pickering emulsion droplet, we consider the adsorption of spherical particles to a spherical liquid-liquid interface in order to investigate the curvature effect on the particle adsorption. By taking into account both the surface and the volume energies due to the presence of a particle, we show that the equilibrium contact angle is determined by the classical Young's equation although the adsorption energy depends on the curvature. We also calculate the partitioning of the colloidal particles among the two liquids and the interface. The distribution of colloidal particles is expressed in terms of the interfacial curvature as well as the relative wettability of the particle.
A Procedure for Automatically Estimating Model Parameters in Optical Motion Capture (2002)

Abstract Model-based optical motion capture systems require knowledge of the position of the markers relative to the underlying skeleton, the lengths of the skeleton's limbs, and which limb each marker is attached to. These model parameters are typically assumed and entered into the system manually, although techniques exist for calculating some of them, such as the position of the markers relative to the skeleton's joints. We present a fully automatic procedure for determining these model parameters. It tracks the 2D positions of the markers on the cameras' image planes and determines which markers lie on each limb before calculating the position of the underlying skeleton. The only assumption is that the skeleton consists of rigid limbs connected with ball joints. The proposed system is demonstrated on a number of real data examples and is shown to calculate good estimates of the model parameters in each.
An electrospray-based, ozone-free air purification technology (2007)

A zero-pressure-drop, ozone-free air purification technology is reported. Contaminated air was directed into a chamber containing an array of electrospray wick sources. The electrospray sources produce an aerosol of tiny, electrically charged aqueous droplets. Charge was transferred from the droplets onto polar and polarizable species in the contaminated air stream and the charged contaminants were extracted using an electric field and deposited onto a metal surface. Purified air emerged from the other end of the chamber. The very small aqueous electrospray droplets completely evaporate so that the process is essentially dry and no liquid solvent is collected or recirculated. The air purification efficiency was measured as a function of particle size, air flow rate, and specific system design parameters. The results indicate that the electrospray-based air purification system provides high air purification efficiency over a wide range of particle size and, due to the very low power and liquid consumption rate, can be scaled up for the purification of arbitrarily large quantities of air.
Does the Pleth Variability Index Indicate the Respiratory-Induced Variation in the Plethysmogram and Arterial Pressure Waveforms? (2008)

This study is the first to demonstrate the ability of PVI, an index automatically derived from the pulse oximeter waveform analysis, to automatically and continuously monitor deltaPOP. This new index has potential clinical applications for noninvasive fluid responsiveness monitoring.
Biodegradable Cellulose Graft Copolymers. I. Condensation-Type Graft Reactions (1981)

Abstract The synthesis of cellulose graft copolymers using condensation reactions to graft onto the cellulose backbone is described. Cellulose acetate (D.S. 2.27) was grafted with MDI and TDI. The cellulose acetate-MDI copolymer was further reacted with hydroxy-terminated poly(butadiene-styrene) copolymer and polyethylene glycol. Grafting was confirmed by Pmr and IR spectroscopy. The copolymers were easily deacetylated with NaOMe. The deacetylated products were readily degraded by cellulysin, faster than cellulose itself.
Self-tuning pole/zero assignment regulators (1979)

In this paper a class of self-tuning regulators is considered which combines a simple recursive least squares estimator with a pole/zero assignment design rule. Two such algorithms are shown to have the self-tuning property (i ) detuned minimum variance regulators ; (ii ) pole-asaignment regulators. The use of these regulators in self-tuning can be of considerable benefit. In particular, case (i ) is useful when minimum variance strategies need unrealistically high-loop gains, since they permit an engineering trade-off between optimality and practicality. Case (ii ) is of use in regulating non-minimum phase systems or systems involving unknown time delays. Such systems are frequently encountered in discrete time control and cannot be handled by direct minimum variance methods.
Neutralization as a Means of Controlling Corrosion of Refinery Equipment (1950)

This paper summarizes the results obtained by using neutralizers as a means of controlling corrosion of refinery equipment. The methods employed in injecting sodium hydroxide, ammonia, and lime are presented. The ammonia distribution system serving the refinery is described. Information is presented in detail on the results obtained on the use of ammonia in controlling corrosion of equipment in connection with distillation, cracking, gas absorption, debutanization and steam systems. The injection of sodium hydroxide and lime into cracking units is discussed as well as the use of sodium hydroxide and soaps in controlling corrosion of distillation equipment.
Choreoathetosis, hypothyroidism, and pulmonary alterations due to human NKX2-1 haploinsufficiency (2002)

The occurrence of neurological symptoms and developmental delay in patients affected by congenital hypothyroidism (CH) has been attributed to the lack of thyroid hormone in the developing CNS. Accordingly, after the introduction of neonatal screening programs for CH, which allowed early and adequate treatment, an almost normal outcome for most CH patients could be achieved. However, a few patients did not reach this favorable outcome despite early and adequate treatment. Here we describe five patients with variable degrees of CH who suffered from choreoathetosis, muscular hypotonia, and pulmonary problems, an association of symptoms that had not been described before this study. Since this clinical picture matched the phenotype of mice targeted for deletion of the transcription factor gene Nkx2-1, we investigated the human NKX2-1 gene in these five patients. We found heterozygous loss of function mutations in each of these five patients, e.g., one complete gene deletion, one missense mutation (G2626T), and three nonsense mutations (2595insGG, C2519A, C1302A). Therefore, the unfavorable outcome in patients with CH, especially those with choreoathetosis and pulmonary symptoms, can be explained by mutations in the NKX2-1 gene rather than by hypothyroidism. Moreover, the association of symptoms in the patients with NKX2-1 mutations points to an important role of human NKX2-1 in the development and function of thyroid, basal ganglia, and lung, as already described for rodents.
경영 · 삼림보호 · 임산가공분야 : 목질계 (木質系) Biomass 의 이용 (II) - 폭쇄재의 산가수분해법에 의한 당화 - (1988)

본 연구는 목질계 Biomass의 이용을 위한 전처리법의 하나인 폭쇄법을 이용하여 우리나라의 주요 수종인 소나무(P. densiflora)와 졸참나무(Q. serrata) 및 자작나무(B. platyphylla)의 chip을 폭쇄하여 이를 농황산법으로 가수분해 하였다.
그 결과 최적분해 조건 및 성상은 다음과 같다.
1) 농황산법에 의한 목분의 가수분해 결과 환원당은 75% H₂SO₄에서는 6시간, 65% H₂SO₄에서는 12시간 반응에서 최대 수율을 나타냈으나, 그 수율은 전체적으로 비교적 낮았다.
2) 농황산법에 의한 목분의 2단가수분해에서는 환원당 수율이 6시간 반에서 최대치를 나타냈으며, 그 수뮬은 1) 항보다 5배 이상 증가하였으므로 농황산법에 의한 산가수분해에서는 2단가수분해가 필요하다고 생각된다.
3) 폭쇄처리재의 2단가수분해에서는 3시간 반응에서 환원당 수율이 최대치를 나타냈으며, 고압처리재의 경우 최대 환원당 수율에 도달하는 반응시간이 저압처리재보다 길었다.
4) 침엽수 폭쇄처리재의 2단가수분해 결과 환원당 스율이 압력에 따라 근소한 차이를 보였지만, 활엽수 폭쇄처리재에서는 오리혀 고압처리가 저압처리보다 환원당 수율이 낮았다.
5) 1% NaOH로 추출한 폭쇄재의 가수분해는 무처리 폭쇄재보다 환원당 수율이 낮았다.
6) 폭쇄지 가수분해약의 당조성은 활엽수의 경우에는 xylose와 glucose잔기만으로 구성되었으며, 침엽수인 소나무에서는 xylose와 glucose잔기 이외에 mannose잔기가 소량 포함되어 있었다.
또한 고압처리일 수록 glucose잔기의 함량이 높게 나타났다.
Astrocytes induce several blood–brain barrier properties in non-neural endothelial cells (1999)

The passage of immunocompetent cells across the blood-brain barrier (BBB) is regulated at the level of the cerebral capillaries which have specific morphological and biochemical properties. We have developed and characterized an in vitro model of the BBB using immortalized human endothelial cells (ECV 304) induced by rat astrocytes. In this model, endothelial cells are attached together by continuous intercellular junctions with numerous tight junctions, develop a permeability barrier having a significant transcellular electrical resistance, possess high activities of gamma-glutamyl transpeptidase (gamma-GTP) and express the brain-type glucose transporter 1 (GLUT-1). These parameters are also characteristic of brain capillary endothelial cells. Under the culture conditions used, the ECV 304 cells express the intercellular adhesion molecule-1 (ICAM-1) on the external plasma membrane at concentrations which could permit lymphocyte adhesion to be studied.
Bootstrapping statistical parsers from small datasets (2003)

We present a practical co-training method for bootstrapping statistical parsers using a small amount of manually parsed training material and a much larger pool of raw sentences. Experimental results show that unlabelled sentences can be used to improve the performance of statistical parsers. In addition, we consider the problem of boot-strapping parsers when the manually parsed training material is in a different domain to either the raw sentences or the testing material. We show that boot-strapping continues to be useful, even though no manually produced parses from the target domain are used.
A 1R/1W SRAM Cell Design to Keep Cell Current and Area Saving against Simultaneous Read/Write Disturbed Accesses (2007)

A guarantee obligation of keeping a Static-Noise-Margin (SNM), a Write-Margin (WRTM), and a cell current (Icell) even against a simultaneous Read/Write (R/W) disturbed access at the same column is required for a 1R/1W (1R/1W) SRAM. We have verified that it is difficult for the previously proposed techniques [1]-[5] so far to meet all the requirements simultaneously without any decrease in Icell or any significant area penalty. In order to address this issue, a new cell design technique for the 1R/1W SRAM cell with 8Tr's has been proposed and demonstrated in a 65 nm CMOS technology. It has been shown that Icell in the R/W disturbed column can be increased by 77% and 195% at V dd =0.9 V and 0.6 V, respectively, and a cell size can be reduced by 15%, compared with the conventional column-based cell power-terminal bias (VDDM) control [1], [2] assuming that the same Icell of 9 μA at V dd =0.9 V has to be provided. Compared with the conventional scheme, it has been found that the proposed Write-Bit-Line precharge level (VWBL) control and column-based cell source-terminal bias (VSSM) control can provide a 1.45-times larger SNM for Write-Word-Line (WWL) disturbed cells and a 1.7-fold larger WRTM while keeping the same Icell, respectively.
Medicaid and disability: the unlikely entitlement. (1989)

Medicaid's extensive and relatively adaptable benefit categories have proved to be singularly suitable to disabled people. The program assists almost one-half of all persons whose disabilities stop them from working. Two primary factors account for this outcome: Medicaid through accretion has taken on new functions and clienteles and, as a welfare program embracing both health and social services rather than offering social insurance, has aptly aided people with disabilities meeting its income qualifications. A proposed revision to Medicaid pending in Congress allowing persons to buy into the program would increase both its constituency and its palatability to recipients and to the broader public.
A quantitative analysis of nuclear factor I/DNA interactions (1988)

Nuclear factor I (NFI) was purified to homogeneity from porcine liver by DNA-affinity chromatography and displays a single band with a molecular weight of 36 kDa in SDS-polyacrylamide gels. The purified protein was used to determine absolute equilibrium binding constants by gel retardation techniques for a variety of DNA fragments with genuine or mutated NFI binding sites and a number of DNA fragments derived from various eukaryotic promoters carrying the CCAAT-box as a half-site for NFI binding. We present a model which allows prediction of the functional significance of mutated NFI binding-sites from sequence data. The data suggest that the single molecular species of NFI from porcine liver may not be able to recognize and activate the -CCAAT- promoter element in vivo without additional interactions, e.g. with other proteins.
Exploiting Lineage for Confidence Computation in Uncertain and Probabilistic Databases (2008)

We study the problem of computing query results with confidence values in ULDBs: relational databases with uncertainty and lineage. ULDBs, which subsume probabilistic databases, offer an alternative decoupled method of computing confidence values: Instead of computing confidences during query processing, compute them afterwards based on lineage. This approach enables a wider space of query plans, and it permits selective computations when not all confidence values are needed. This paper develops a suite of algorithms and optimizations for a broad class of relational queries on ULDBs. We provide confidence computation algorithms for single data items, as well as efficient batch algorithms to compute confidences for an entire relation or database. All algorithms incorporate memoization to avoid redundant computations, and they have been implemented in the Trio prototype ULDB database system. Performance characteristics and scalability of the algorithms are demonstrated through experimental results over a large synthetic dataset.
Physiological Responses to Low-Intensity Cardiac Rehabilitation Exercises (1980)

This study determined the oxygen consumption, heart rate, and blood pressure responses in healthy subjects to calisthenic exercises designed for convalescing patients with cardiac problems. Comparisons of the different exercises showed intersubject variability in oxygen consumption per unit of body weight and in cardiovascular responses. The exercises showing the greatest variability in oxygen consumption, however, were not always the exercises with the greatest variability in heart rate and blood pressure. Upper extremity exercises tended to evoke a greater demand on the cardiovascular system, especially if the isometric component was large. These data suggest the necessity of carefully monitoring cardiovascular response when using a variety of calisthenic exercises in the rehabilitation of patients such as those with cardiac limitations and should provide useful information for prescribing exercise.
Dome's kick tolerance formula for safe Beaufort Sea drilling (1981)

One of the monoclinic P21 forms of uteroglobin, a progesterone-binding protein secreted by the rabbit uterus, was crystallized and subjected to X-ray diffraction analysis at 1.64 A resolution. The analysis was refined to an R factor of 0.19 and the 1096 non-hydrogen atomic positions are known to an accuracy of about 0.18 A. The average isotropic temperature factor B was 10.4 A2. Uteroglobin is a dimer of two independent polypeptide chains of 70 residues linked by two disulfide bridges and related by a pseudo binary axis. Each monomer is folded into four alpha-helices. An oblong hydrophobic pocket is observed inside the dimer, and the possibility that it represents a progesterone-binding site is discussed. The present model includes 165 possible sites for water molecules, of which six are located in the hydrophobic pocket. Polar groups are involved in hydrogen bonding (intramolecular, intermolecular or with water molecules).
Epidemiology of pancreas cancer in Los Angeles (1981)

The characteristics of the 3614 Los Angeles County residents in whom cancer of the exocrine pancreas was diagnosed during the period 1972-1977 were compared with those of all county residents and patients in whom any cancer was diagnosed during the same period. Seventy-nine percent of the diagnoses had been pathologically verified. This disease still preferentially afflicts the old, the black, and men, although the differences in risk with factors other than age are modest. The disease is not evenly distributed by social class, or over time, although it is not clear that the observed differences reflect etiology. The distributions with respect to important categories of occupation and industry, religion, marital status, geography of residence, and birthplace were rather uniform. Although there is no obvious explanation for any of several unexpected minor inequities in the pattern of incidence, there is no compelling evidence to support any specific environmental cause. There is substantial evidence which is inconsistent with those environmental hypotheses that have been proposed previously.