gebhart/patrepeval huggingface dataset:
Antagonistic actions of retinoic acid and dexamethasone on anchorage-independent growth and epidermal growth factor binding of normal rat kidney cells. (1984)

Type beta transforming growth factor (TGF-beta), in combination with epidermal growth factor (EGF) can induce nonneoplastic normal rat kidney cells to express a transformed phenotype and to form colonies in soft agar. Retinoic acid by itself has no effect on colony formation; but at concentrations of 10(-9) M or greater, it can greatly enhance the response of the cells to EGF and TGF-beta, as measured by colony growth in soft agar and expression of a transformed morphology in monolayer culture. Dexamethasone, at concentrations above 10(-9) M, has an opposite effect, inhibiting the TGF-beta-dependent formation of colonies in soft agar and restoring a more normal morphology to the cells. Added simultaneously, these two modulators act antagonistically; at equimolar concentrations, their opposite effects on colony formation are canceled. Retinoic acid and dexamethasone also have opposite and antagonistic effects on the binding of 125I-labeled EGF to normal rat kidney cells. Retinoic acid enhances the binding of EGF up to 6-fold, while dexamethasone reduces the binding to 50 to 60% of control levels. These effects on EGF binding show a dose dependence similar to the effects on colony formation in soft agar and on morphology in monolayer culture. Optimal effects on binding are observed 40 to 60 hr after treatment of the cells. It can be concluded that the abilities of retinoic acid and dexamethasone to alter expression of the transformed phenotype induced by treatment of normal rat kidney cells with TGF-beta and EGF are mediated at least in part through their effects on the EGF receptor.
Some Properties of the Quaternary Ammonium Anion-Exchange Resin-Triiodide Disinfectant for Water (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSome Properties of the Quaternary Ammonium Anion-Exchange Resin-Triiodide Disinfectant for WaterGary L. Hatch, Jack L. Lambert, and Louis R. FinaCite this: Ind. Eng. Chem. Prod. Res. Dev. 1980, 19, 2, 259–263Publication Date (Print):June 1, 1980Publication History Published online1 May 2002Published inissue 1 June 1980https://pubs.acs.org/doi/10.1021/i360074a026https://doi.org/10.1021/i360074a026research-articleACS PublicationsRequest reuse permissionsArticle Views988Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
PEPSC: A Power-Efficient Processor for Scientific Computing (2011)

The rapid advancements in the computational capabilities of the graphics processing unit (GPU) as well as the deployment of general programming models for these devices have made the vision of a desktop supercomputer a reality. It is now possible to assemble a system that provides several TFLOPs of performance on scientific applications for the cost of a high-end laptop computer. While these devices have clearly changed the landscape of computing, there are two central problems that arise. First, GPUs are designed and optimized for graphics applications resulting in delivered performance that is far below peak for more general scientific and mathematical applications. Second, GPUs are power hungry devices that often consume 100-300 watts, which restricts the scalability of the solution and requires expensive cooling. To combat these challenges, this paper presents the PEPSC architecture - an architecture customized for the domain of data parallel scientific applications where power-efficiency is the central focus. PEPSC utilizes a combination of a two-dimensional single-instruction multiple-data (SIMD) data path, an intelligent dynamic prefetching mechanism, and a configurable SIMD control approach to increase execution efficiency over conventional GPUs. A single PEPSC core has a peak performance of 120 GFLOPs while consuming 2W of power when executing modern scientific applications, which represents an increase in computation efficiency of more than 10X over existing GPUs.
Superconducting Interfaces Between Insulating Oxides (2007)

At interfaces between complex oxides, electronic systems with unusual electronic properties can be generated. We report on superconductivity in the electron gas formed at the interface between two insulating dielectric perovskite oxides, LaAlO3 and SrTiO3. The behavior of the electron gas is that of a two-dimensional superconductor, confined to a thin sheet at the interface. The superconducting transition temperature of congruent with 200 millikelvin provides a strict upper limit to the thickness of the superconducting layer of congruent with 10 nanometers.
Wavelength encoded OCT imaging using swept-source (2007)

Wavelength-encoded imaging uses wavelength division multiplexing to produce cross-sectional images without mechanical scanning, and could be of a great interest in endoscope applications. In this paper, a scheme for wavelength-encoded imaging using time-encoded Frequency-domain optical coherence tomography (swept-source optical coherence tomography, SS-OCT) is presented. This approach implements swept broadband source with narrow instantaneous spectral width and low dispersion diffraction grating to simultaneously produce depth-lateral imaging of the sample. Compared to previous spectral-domain wavelength-encoded endoscope, the proposed method enables high-speed and high dynamic range detection. System design such as image resolvable points, imaging resolution as well as theoretical analysis of the interference signal pattern are developed.
Human Shape and Pose Tracking Using Keyframes (2014)

This paper considers human tracking in multi-view setups and investigates a robust strategy that learns online key poses to drive a shape tracking method. The interest arises in realistic dynamic scenes where occlusions or segmentation errors occur. The corrupted observations present missing data and outliers that deteriorate tracking results. We propose to use key poses of the tracked person as multiple reference models. In contrast to many existing approaches that rely on a single reference model, multiple templates represent a larger variability of human poses. They provide therefore better initial hypotheses when tracking with noisy data. Our approach identifies these reference models online as distinctive keyframes during tracking. The most suitable one is then chosen as the reference at each frame. In addition, taking advantage of the proximity between successive frames, an efficient outlier handling technique is proposed to prevent from associating the model to irrelevant outliers. The two strategies are successfully experimented with a surface deformation framework that recovers both the pose and the shape. Evaluations on existing datasets also demonstrate their benefits with respect to the state of the art.
Regulation of system y+ arginine transport capacity in differentiating human intestinal Caco-2 cells (1995)

This study describes the ability of passaged human intestinal Caco-2 cells to regulate transport of L-arginine via system y+. Subconfluent and confluent cells possessed system y+ activity, as determined by the sodium independence of uptake and the pattern of inhibition by amino acid analogues or N-ethylmaleimide. Initial rates of arginine uptake via system y+ decreased as the cells advanced from the undifferentiated to the differentiated state following culture passaging. Furthermore, kinetic analysis of the leucine-insensitive portion of uptake indicated that the Caco-2 system y+ transport capacity decreased with cell age, dropping from a maximal velocity (Vmax) = 1,094 pmol.mg-1.min-1 [Michaelis constant (Km) = 41 microM] in undifferentiated cells 2 days postseeding to Vmax = 320 pmol.mg-1.min-1 (Km = 37 microM) in confluent cells 9 days postseeding (from cells of the same passage). Northern analysis indicated that the levels of a single 7.9-kb mCAT-1 mRNA species were relatively constant over the course of Caco-2 differentiation and therefore were unsynchronized with the system y+ relative transport activities. It is concluded that the Caco-2 capacity to transport arginine via system y+ may be downregulated by posttransitional modifications in confluent cells compared with newly passaged undifferentiated cells. These data serve as a well-defined in vitro model for further studies regarding regulation of arginine transport in epithelial cells.
Antidepression action of BDNF requires and is mimicked by Gαi1/3 expression in the hippocampus (2018)

Stress-related alterations in brain-derived neurotrophic factor (BDNF) expression, a neurotrophin that plays a key role in synaptic plasticity, are believed to contribute to the pathophysiology of depression. Here, we show that in a chronic mild stress (CMS) model of depression the Gαi1 and Gαi3 subunits of heterotrimeric G proteins are down-regulated in the hippocampus, a key limbic structure associated with major depressive disorder. We provide evidence that Gαi1 and Gαi3 (Gαi1/3) are required for the activation of TrkB downstream signaling pathways. In mouse embryonic fibroblasts (MEFs) and CNS neurons, Gαi1/3 knockdown inhibited BDNF-induced tropomyosin-related kinase B (TrkB) endocytosis, adaptor protein activation, and Akt-mTORC1 and Erk-MAPK signaling. Functional studies show that Gαi1 and Gαi3 knockdown decreases the number of dendrites and dendritic spines in hippocampal neurons. In vivo, hippocampal Gαi1/3 knockdown after bilateral microinjection of lentiviral constructs containing Gαi1 and Gαi3 shRNA elicited depressive behaviors. Critically, exogenous expression of Gαi3 in the hippocampus reversed depressive behaviors in CMS mice. Similar results were observed in Gαi1/Gαi3 double-knockout mice, which exhibited severe depressive behaviors. These results demonstrate that heterotrimeric Gαi1 and Gαi3 proteins are essential for TrkB signaling and that disruption of Gαi1 or Gαi3 function could contribute to depressive behaviors.
DP-Miner: Design Pattern Discovery Using Matrix (2007)

Design patterns document expert design experience in software system development. They have been applied in many existing software systems. However, pattern information is generally lost in the source code. Discovering design patterns from source code may help understand system designs and further change the systems. In this paper, we present a novel approach to discovering design patterns by defining the structural characteristics of each design pattern in terms of weight and matrix. Our discovery process includes several analysis phases. Our approach is based on the XMI standard so that it is compatible with other techniques following such standard. We also develop a toolkit to support our approach. An industrial size case study is conducted to evaluate our approach and tool
Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction (2010)

Blood vessel networks expand in a 2-step process that begins with vessel sprouting and is followed by vessel anastomosis. Vessel sprouting is induced by chemotactic gradients of the vascular endothelial growth factor (VEGF), which stimulates tip cell protrusion. Yet it is not known which factors promote the fusion of neighboring tip cells to add new circuits to the existing vessel network. By combining the analysis of mouse mutants defective in macrophage development or VEGF signaling with live imaging in zebrafish, we now show that macrophages promote tip cell fusion downstream of VEGF-mediated tip cell induction. Macrophages therefore play a hitherto unidentified and unexpected role as vascular fusion cells. Moreover, we show that there are striking molecular similarities between the pro-angiogenic tissue macrophages essential for vascular development and those that promote the angiogenic switch in cancer, including the expression of the cell-surface proteins TIE2 and NRP1. Our findings suggest that tissue macrophages are a target for antiangiogenic therapies, but that they could equally well be exploited to stimulate tissue vascularization in ischemic disease.
Load balancing based on pseudo-anycast and pseudo-mobility in IPv6 (2004)

We proposed a new load balancing mechanism, called LBAM (load balancing based on pseudo-anycast and pseudo-mobility in IPv6), by which sessions can be distributed across a pool of servers for maximum performance. Load balancing is needed in many fields, such as Web servers, FTP server and NAT gateway, and there exist several approaches for load balancing. However, current approaches have problems such as poor scalability, inability to balance session flow, long latency time, and topological constraint on server pools. In this paper, we describe how LBAM works in principle without the above problems. We also present our simulation work using NS-2 and discuss performance comparison between LBAM and other load balancing mechanisms. The results show that LBAM has a very advanced performance and scalability. Finally, the ubiquitous applications of LBAM in NGI (next generation Internet) are presented.
Reviews (1972)

Reviews Get access Data Processing in Biology and Geology.— David L. Hull, ed. Systematics Association, Academic Press, London and New York. 346 pp. $15.00. David L. Hull David L. Hull Search for other works by this author on: Oxford Academic PubMed Google Scholar Systematic Biology, Volume 21, Issue 1, March 1972, Page 132, https://doi.org/10.1093/sysbio/21.1.132a Published: 01 March 1972
Strained SiGe Channels for Band-Edge PMOS Threshold Voltages With Metal Gates and High- $k$ Dielectrics (2010)

Achieving low p-channel metal-oxide-semiconductor (PMOS) threshold voltages with metal gates and high- <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">k</i> dielectrics is challenging with conventional gate-first complimentary metal-oxide-semiconductor process integration. This study, for the first time, explores the tradeoffs in using different combinations of thin-strained Si <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1 -</sub> <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</i> Ge <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</i> channels, boron counterdopings, Si capping layers, and different metal-gate electrodes to obtain low PMOS threshold voltages with metal gate on high- <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">k</i> dielectrics in a gate-first integration technology. Device simulations are used to explain the experimental threshold voltage trends with varying Si <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1 -</sub> <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</i> Ge <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</i> thicknesses, boron counterdopings, and gate work functions.
Pathogenesis of hyperinflation in chronic obstructive pulmonary disease (2014)

Chronic obstructive pulmonary disease (COPD) is a preventable and treatable lung disease characterized by airflow limitation that is not fully reversible. In a significant proportion of patients with COPD, reduced lung elastic recoil combined with expiratory flow limitation leads to lung hyperinflation during the course of the disease. Development of hyperinflation during the course of COPD is insidious. Dynamic hyperinflation is highly prevalent in the advanced stages of COPD, and new evidence suggests that it also occurs in many patients with mild disease, independently of the presence of resting hyperinflation. Hyperinflation is clinically relevant for patients with COPD mainly because it contributes to dyspnea, exercise intolerance, skeletal muscle limitations, morbidity, and reduced physical activity levels associated with the disease. Various pharmacological and nonpharmacological interventions have been shown to reduce hyperinflation and delay the onset of ventilatory limitation in patients with COPD. The aim of this review is to address the more recent literature regarding the pathogenesis, assessment, and management of both static and dynamic lung hyperinflation in patients with COPD. We also address the influence of biological sex and obesity and new developments in our understanding of hyperinflation in patients with mild COPD and its evolution during progression of the disease.
Transient expression of marker genes in immature zygotic embryos of spring wheat (<i>Triticum aestivum</i>) through microprojectile bombardment (1991)

Transient expression of marker genes (cat and uidA) delivered by the Biolistics microprojectile bombardment technique has been detected in immature zygotic embryos of wheat (Triticum aestivum L.). The DNA expression vectors that gave maximal expression of both cat (pCaMVI 1 CN) and uidA (pCaMVI 1 GusN) genes had an alcohol dehydrogenase (Adh1) intron 1 cloned in between the cauliflower mosaic virus (CaMV35S) promoter and the coding region of the gene. Detection of chloramphenicol acetyltransferase (CAT) activity in response to cat gene was complicated by the presence of an inhibitor of CAT activity as well as an endogenous CAT-Iike activity. The results of enzymatic assays were confirmed by an ELISA technique using CAT-specific antibodies, whereas the β-glucuronidase (GUS) activity following the introduction of the uidA gene was confirmed by both histochemical and fluorometric techniques.Key words: cereal transformation, gene expression, ELISA, wheat.
Analysis of Cd44-Containing Lipid Rafts (1999)

CD44, the major cell surface receptor for hyaluronic acid (HA), was shown to localize to detergent-resistant cholesterol-rich microdomains, called lipid rafts, in fibroblasts and blood cells. Here, we have investigated the molecular environment of CD44 within the plane of the basolateral membrane of polarized mammary epithelial cells. We show that CD44 partitions into lipid rafts that contain annexin II at their cytoplasmic face. Both CD44 and annexin II were released from these lipid rafts by sequestration of plasma membrane cholesterol. Partition of annexin II and CD44 to the same type of lipid rafts was demonstrated by cross-linking experiments in living cells. First, when CD44 was clustered at the cell surface by anti-CD44 antibodies, annexin II was recruited into the cytoplasmic leaflet of CD44 clusters. Second, the formation of intracellular, submembranous annexin II-p11 aggregates caused by expression of a trans-dominant mutant of annexin II resulted in coclustering of CD44. Moreover, a frequent redirection of actin bundles to these clusters was observed. These basolateral CD44/annexin II-lipid raft complexes were stabilized by addition of GTPgammaS or phalloidin in a semipermeabilized and cholesterol-depleted cell system. The low lateral mobility of CD44 in the plasma membrane, as assessed with fluorescent recovery after photobleaching (FRAP), was dependent on the presence of plasma membrane cholesterol and an intact actin cytoskeleton. Disruption of the actin cytoskeleton dramatically increased the fraction of CD44 which could be recovered from the light detergent-insoluble membrane fraction. Taken together, our data indicate that in mammary epithelial cells the vast majority of CD44 interacts with annexin II in lipid rafts in a cholesterol-dependent manner. These CD44-containing lipid microdomains interact with the underlying actin cytoskeleton.
TRANSIT: SIMPLER, MORE EFFICIENT (2000)

This article speculates on transit options in the next century. In the 21st century, new vehicles and technologies that we can hardly envision now will be available to transit services. The effectiveness of these innovations will rest in making wise decisions about how to best apply them. Transit agencies must broaden their product range by encouraging more transportation options: buses, light rail, streetcars, shuttle vans, car sharing, carpooling, and high-occupancy vehicle lanes. They also can enhance safety and comfort with clean, well-lit stations. And, they can ensure that transit planning creates easy links among various modes of transportation. On existing technology is the satellite global positioning system (GPS). With GPS onboard buses or other transit vehicles, dispatchers can see where individual vehicles are along their routes. Electronic fare cards could simplify boarding for both riders and operators. New types of vehicles, such as hybrid buses and passenger vans, which offer quieter service and greater efficiency, will increase transit options in the future. In the 20th century, tax dollars created vast expanses of pavement. Efforts in the next century must focus on creating transit links that knit communities together rather than encouraging further sprawl.
Note: A high dynamic range, linear response transimpedance amplifier (2012)

We have built a high dynamic range (nine decade) transimpedance amplifier with a linear response. The amplifier uses junction-gate field effect transistors (JFETs) to switch between three different resistors in the feedback of a low input bias current operational amplifier. This allows for the creation of multiple outputs, each with a linear response and a different transimpedance gain. The overall bandwidth of the transimpedance amplifier is set by the bandwidth of the most sensitive range. For our application, we demonstrate a three-stage amplifier with transimpedance gains of approximately 109Ω, 3 × 107Ω, and 104Ω with a bandwidth of 100 Hz.
High modulus semi‐crystalline polymers by solid state rolling (1982)

Abstract Solid state rolling of semi‐crystalline polymers is shown to be an effective method of producing high strength, high modulus tape at acceptable production rates. High density polyethylene tape was produced having a tensile strength exceeding 300 MPa and a tensile modulus of 8.7 GPa at production rates exceeding 8 m/min. A significant factor in producing highly oriented tape by the rolling process is roll temperature. Increasing the roll temperature from 25°C to 125°C not only increases the maximum extent of orientation achievable, but increases the mechanical properties at a given degree of thickness reduction. Internal frictional heat development limited the maximum thickness reduction ratio of polypropylene to 6.6:1. This reduction was reached by rolling at 150°C. The resultant tape had a tensile modulus of 5.1 GPa and a tensile strength of 300 MPa.