gebhart/patrepeval huggingface dataset:
Test automation for multi-touch user interfaces of industrial applications (2015)

In this paper we discuss challenges in testing multi-touch user interfaces. We report on our experiences with testing multi-touch UIs in context of industrial software applications for machinery control. For this purpose we developed a reusable capture/replay approach for recording multi-touch gestures. The tool support is used to establish a gesture library capturing the wide range of individual variants in multi-touch interactions for regression testing industrial applications.
Analyzing the process of installing rogue software (2009)

This practical experience report presents the results of an experiment aimed at understanding the sequence of malicious actions following a remote compromise. The type of rogue software installed during attacks was used to classify and understand sequences of malicious actions. For this experiment, we used four Linux target computers running SSH with simple passwords. During the eight-month data collection period, we recorded a total of 1,171 attack sessions. In these sessions, attackers typed a total of 20,335 commands that we categorized into 24 specific actions. These actions were analyzed based on the type of rogue software installed by attackers.
Cycloaddition reactions of 3-(phenylthio)-3-buten-2-one: synthesis of functionalized dihydropyran derivatives and their ring-opening reactions (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCycloaddition reactions of 3-(phenylthio)-3-buten-2-one: synthesis of functionalized dihydropyran derivatives and their ring-opening reactionsKen Takaki, Michio Yamada, and Kenji NegoroCite this: J. Org. Chem. 1982, 47, 27, 5246–5250Publication Date (Print):December 1, 1982Publication History Published online1 May 2002Published inissue 1 December 1982https://pubs.acs.org/doi/10.1021/jo00148a004https://doi.org/10.1021/jo00148a004research-articleACS PublicationsRequest reuse permissionsArticle Views214Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Experimental treatments for asthma (1997)

There has been increased recognition of the importance of inflammatory cells and their products in the pathogenesis of asthma. From this recognition has evolved a number of new approaches to treat the various components of the asthmatic inflammatory response. Nonselective anti-inflammatory agents such as cyclosporine and gold appear to decrease symptoms and allow a steroid-sparing effect in many cases, though side effects from cyclosporine often necessitate dose reduction. Novel oral compounds as the 5-lipoxygenase inhibitors have been effective in controlling asthma symptoms triggered by various stimuli, and the cysteinyl leukotriene receptor antagonists have shown promise in this regard as well. Neurokinin antagonists, inhaled loop diuretics, and lidocaine may play significant roles in asthma therapy through inhibition of neurogenic inflammation and possibly mast cell function. Inhibition of mast cell products by existing drugs such as heparin or the development of specific inhibitors of mast cell tryptase may also be effective agents, as are selective phosphodiesterase inhibitors, which appear to have anti-inflammatory properties. Finally, specific cytokine antagonists, agonists, inhibitors of T-cell function, selective inducible nitric oxide synthase inhibitors, and even gene-directed strategies may provide not only insights into the pathogenesis of asthma but also novel therapeutic approaches to treat the inflammation in this disease.
A Single Nucleotide Polymorphism in the <i>MDM2</i> Gene: From a Molecular and Cellular Explanation to Clinical Effect (2005)

In a recent article, a candidate pathway approach was taken to try to identify single nucleotide polymorphisms (SNP) that make up the genetic variation, which underlies the phenotypic variation seen between individuals in their susceptibility to cancer and the progression of their disease. The p53 stress response pathway was chosen given its well-documented importance in tumor suppression. A SNP was found which associates with the attenuation of the p53 pathway and the acceleration of tumor formation in humans and data was presented which describe a molecular mechanism for these phenotypes.
Maternal Effects on Sugar Content in Soybean Seeds<sup>1</sup> (1978)

The feasibility of using single‐seed selection to change individual and total sugar content in seeds of soybeans [ Glycine max (L.) Merr.] was investigated. In four sets of crosses involving six genotypes, comparisons of F 1 seeds with parental selfed seed failed to show a consistent paternal effect. In two crosses, variances of sugar content among F 2 seeds were compared to corresponding parental variances, without detecting any significant genetic variation. In the one cross studied on an individual plant basis, the average individual and total sugar content of seeds on F 1 plants fell midway between those of seeds produced on the two parents. Comparisons of means of reciprocal F 1 plants gave no indication of cytoplasmic effects. Results indicate that selection for sugar content among single seeds would be inferior to selection among individual plants or plant progenies.
The Melanin-Concentrating Hormone Receptor Couples to Multiple G Proteins to Activate Diverse Intracellular Signaling Pathways (2000)

The receptor for melanin-concentrating hormone (MCH) was recently identified as the orphan G protein-coupled receptor SLC-1. In this study, a CHO cell line expressing the MCH receptor (Kd = 1.3 nM; binding capacity, 3.6 pmol/mg protein) is used to assess the ability of the MCH receptor to couple to Gi, Go, and Gq proteins. The results demonstrate that MCH inhibits forskolin-stimulated cAMP production in a pertussis toxin- (PTX)-sensitive manner in CHO-MCHR cells (EC50 = 100 pM), indicating that the MCH receptor couples to one or more members of the Gi subfamily of G proteins. In addition, MCH stimulates increases in phosphoinositide metabolism (EC50 = 50 nM) and in intracellular free Ca2+ levels (EC50 = 10 nM). MCH-stimulated inositol phosphate production and increases in intracellular free Ca2+ are partially inhibited (60% and 40%, respectively) by PTX pretreatment, demonstrating that there are at least two components of each of these signaling pathways. One component is PTX sensitive and therefore mediated through a Gi/Go protein. A distinct G protein-coupled (probably Gq type) mediates the PTX-insensitive component. To distinguish Gi vs. Go coupling, MCH-stimulated mitogen-activated protein (MAP) kinase activity was examined. Gi and Go use separate signaling pathways to mediate MAP kinase activation in CHOcells. Protein kinase C (PKC) activity is essential in the Go-dependent MAP kinase signaling pathway, but is not required in the GC-dependent MAP kinase signaling pathway. MCH stimulated MAP kinase activity is decreased (50%), but not abolished, by inhibition of PKC activity or depletion of cellular PKC, indicating that MCH-stimulated MAP kinase activity is mediated through both Gi- and Go-dependent signaling mechanisms. The results of this study are the first to clearly demonstrate that the MCH receptor couples to multiple G proteins to mediate several diverse intracellular signaling pathways.
Transmission of Hepatitis C Virus -- Route, Dose, and Titer (1994)

Hepatitis C virus (HCV) is a blood-borne virus that generally circulates in low titers in infected serum. Epidemiologic studies show that the most efficient transmission of HCV is through the transfusion of blood or blood products or the transplantation of organs from infected donors and through the sharing of contaminated needles among injection-drug users1. However, less than half of patients with acute hepatitis C report a history of such exposure. A small number of epidemiologic studies demonstrate that perinatal, sexual, household, and occupational transmission occurs, but our understanding of the risks of transmission in these settings has been limited . . .
Two-dimensional electron gases in Ga-face and N-face AlGaN/GaN heterostructures grown by plasma-induced molecular beam epitaxy and metalorganic chemical vapor deposition on sapphire (2000)

We report on the growth of nominally undoped GaN/AlxGa1−xN/GaN (x&lt;0.4) high mobility heterostructures with N-face or Ga-face polarity on sapphire substrates by plasma-induced molecular beam epitaxy (PIMBE) and metalorganic chemical vapor deposition in order to study the formation and electrical transport properties of polarization induced two-dimensional electron gases (2DEGs). By depositing a thin AlN nucleation layer on the sapphire substrates before the growth of a GaN buffer layer by PIMBE, we were able to change the polarity of the wurtzite films from N to Ga face. The switch in the polarity causes a change in the sign of the spontaneous and piezoelectric polarization directed along the c axis of the strained AlGaN barrier. As a consequence the polarization induced 2DEG is confined at different interfaces in heterostructures with different polarities. The transport properties of the 2DEGs in Ga- and N-face heterostructures were investigated by a combination of capacitance–voltage profiling, Hall effect, and Shubnikov-de Haas measurements. Dominant electron scattering mechanisms are studied in order to provide the knowledge necessary for further improvements of the electron transport properties and performance of AlGaN/GaN based “normal” (based on Ga-face heterostructures) and “inverted” (based on N-face heterostructures) high electron mobility transistors.
Computational Advances in Maximum Likelihood Methods for Molecular Phylogeny (1998)

We have developed a generalization of Kimura's Markov chain model for base substitution at a single nucleotide site. This generalized model incorporates more flexible transition rates and consequently allows irreversible as well as reversible chains. Because the model embodies just the right amount of symmetry, it permits explicit calculation of finite-time transition probabilities and equilibrium distributions. The model also meshes well with maximum likelihood methods for phylogenetic analysis. Quick calculation of likelihoods and their derivatives can be carried out by adapting Baum's forward and backward algorithms from the theory of hidden Markov chains. Analysis of HIV sequence data illustrates the speed of the algorithms on trees with many contemporary taxa. Analysis of some of Lake's data on the origin of the eukaryotic nucleus contrasts the reversible and irreversible versions of the model.
Deformability-based cell classification and enrichment using inertial microfluidics (2011)

The ability to detect and isolate rare target cells from heterogeneous samples is in high demand in cell biology research, immunology, tissue engineering and medicine. Techniques allowing label-free cell enrichment or detection are especially important to reduce the complexity and costs towards clinical applications. Single-cell deformability has recently been recognized as a unique label-free biomarker for cell phenotype with implications for assessment of cancer invasiveness. Using a unique combination of fluid dynamic effects in a microfluidic system, we demonstrate high-throughput continuous label-free cell classification and enrichment based on cell size and deformability. The system takes advantage of a balance between deformability-induced and inertial lift forces as cells travel in a microchannel flow. Particles and droplets with varied elasticity and viscosity were found to have separate lateral dynamic equilibrium positions due to this balance of forces. We applied this system to successfully classify various cell types using cell size and deformability as distinguishing markers. Furthermore, using differences in dynamic equilibrium positions, we adapted the system to conduct passive, label-free and continuous cell enrichment based on these markers, enabling off-chip sample collection without significant gene expression changes. The presented method has practical potential for high-throughput deformability measurements and cost-effective cell separation to obtain viable target cells of interest in cancer research, immunology, and regenerative medicine.
Review: Metabolism of Immunosuppressant Drugs (2002)

Pharmacokinetic concepts provide a basis for individualization of drug therapy to optimize outcomes of the critical-dose drugs cyclosporine (CsA), tacrolimus (TRL), sirolimus (SRL), and mycophenolate mofetil (MMF). The therapeutic range of a drug-defined as the concentrations at which the desired pharmacologic effect is produced without adverse effects in most patients-is difficult to achieve given the significant inter-and intrapatient variability of the effects of a given concentration of therapeutic agents. Because of the highly variable rates of absorption of immunosuppressive agents and clinical responses to given concentrations in transplant recipients, individualization of drug regimens by using therapeutic drug monitoring (TDM) is essential to optimize pharmacotherapy Assessing proclivity for acute rejection episodes in transplant recipients currently is attempted by estimating drug exposure using the area under the time-concentration curve (AUC) for MMF and the average concentration (Cav, the quotient of the AUC and the dosing interval) for CsA. These studies have revealed that low oral bioavailability was a more important predictor of rejection than was a rapid clearance rate. In addition, the degree of intra-individual variability of AUC values correlated with the development of chronic rejection in renal transplant recipients. Similarly, TDM of MMF requires AUC determinations. Low mycophenolic acid (MPA) exposure, as estimated by the AUC, demonstrates a significant association with an increased risk of an acute renal transplant rejection episode. The AUC0-2 estimate of MPA shows good agreement with the 12-hr AUC estimate from samples obtained during the entire dosing interval. In contrast, trough levels are utilized during treatment with TRL or SRL, potent new immunosuppressive agents that display a pleiotropic array of side effects. Standard body measures, including weight and body mass index, poorly predict the concentration of SRL in whole blood. Large inter- and intra-individual differences displayed in patients also could not be predicted by demographic features or by laboratory parameters. When SRL is given with other immunosuppressive agents such as CsA, which shares with SRL mutual microsomal metabolism by the cytochrome P450 3A system, pharmacokinetic interactions occur, especially when the agents are administered concomitantly. Because of the critical-dose nature of most of the recent generation of immunosuppressive agents, therapeutic drug monitoring is becoming increasingly important in the selection of doses and treatment regimens.
Classifier cascades and trees for minimizing feature evaluation cost (2014)

Machine learning algorithms have successfully entered industry through many real-world applications (e.g., search engines and product recommendations). In these applications, the test-time CPU cost must be budgeted and accounted for. In this paper, we examine two main components of the test-time CPU cost, classifier evaluation cost and feature extraction cost, and show how to balance these costs with the classifier accuracy. Since the computation required for feature extraction dominates the test-time cost of a classifier in these settings, we develop two algorithms to efficiently balance the performance with the test-time cost. Our first contribution describes how to construct and optimize a tree of classifiers, through which test inputs traverse along individual paths. Each path extracts different features and is optimized for a specific sub-partition of the input space. Our second contribution is a natural reduction of the tree of classifiers into a cascade. The cascade is particularly useful for class-imbalanced data sets as the majority of instances can be early-exited out of the cascade when the algorithm is sufficiently confident in its prediction. Because both approaches only compute features for inputs that benefit from them the most, we find our trained classifiers lead to high accuracies at a small fraction of the computational cost.
Spread of cochlear excitation during stimulation with pulsed infrared radiation: inferior colliculus measurements (2011)

Infrared neural stimulation (INS) has received considerable attention over the last few years. It provides an alternative method to artificially stimulate neurons without electrical current or the introduction of exogenous chromophores. One of the primary benefits of INS could be the improved spatial selectivity when compared with electrical stimulation. In the present study, we have evaluated the spatial selectivity of INS in the acutely damaged cochlea of guinea pigs and compared it to stimulation with acoustic tone pips in normal-hearing animals. The radiation was delivered via a 200 µm diameter optical fiber, which was inserted through a cochleostomy into the scala tympani of the basal cochlear turn. The stimulated section along the cochlear spiral ganglion was estimated from the neural responses recorded from the central nucleus of the inferior colliculus (ICC). ICC responses were recorded in response to cochlear INS using a multichannel penetrating electrode array. Spatial tuning curves (STCs) were constructed from the responses. For INS, approximately 55% of the activation profiles showed a single maximum, ∼22% had two maxima and ∼13% had multiple maxima. The remaining 10% of the profiles occurred at the limits of the electrode array and could not be classified. The majority of ICC STCs indicated that the spread of activation evoked by optical stimuli is comparable to that produced by acoustic tone pips.
<scp>TET</scp> proteins and 5‐methylcytosine oxidation in hematological cancers (2014)

DNA methylation has pivotal regulatory roles in mammalian development, retrotransposon silencing, genomic imprinting, and X-chromosome inactivation. Cancer cells display highly dysregulated DNA methylation profiles characterized by global hypomethylation in conjunction with hypermethylation of promoter CpG islands that presumably lead to genome instability and aberrant expression of tumor suppressor genes or oncogenes. The recent discovery of ten-eleven-translocation (TET) family dioxygenases that oxidize 5mC to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) in DNA has led to profound progress in understanding the mechanism underlying DNA demethylation. Among the three TET genes, TET2 recurrently undergoes inactivating mutations in a wide range of myeloid and lymphoid malignancies. TET2 functions as a bona fide tumor suppressor particularly in the pathogenesis of myeloid malignancies resembling chronic myelomonocytic leukemia (CMML) and myelodysplastic syndromes (MDS) in human. Here we review diverse functions of TET proteins and the novel epigenetic marks that they generate in DNA methylation/demethylation dynamics and normal and malignant hematopoietic differentiation. The impact of TET2 inactivation in hematopoiesis and various mechanisms modulating the expression or activity of TET proteins are also discussed. Furthermore, we also present evidence that TET2 and TET3 collaborate to suppress aberrant hematopoiesis and hematopoietic transformation. A detailed understanding of the normal and pathological functions of TET proteins may provide new avenues to develop novel epigenetic therapies for treating hematological malignancies.
A simple and rapid method for extracting bacterial DNA from intestinal microflora for ERIC-PCR detection (2008)

The chelex method is recommended for ERIC-PCR experiments in view of its simplicity and cost-effectiveness; and it is suitable for extracting total DNA from intestinal micro-organisms, particularly for handling a large number of samples.
Control Method for Harmonic Voltage Injection to Achieve Noise Reduction in Position‐Sensorless Control of Permanent‐Magnet Synchronous Motors at Low Speeds (2012)

Abstract In this study, we examine the relationship between harmonic voltage injection, acoustic noise, and position estimation performance in a PMSM when a position‐sensorless control method involving harmonic voltage injection is used at low speeds. Further, we propose a novel control method for voltage injection; this method can be used to reduce acoustic noise in the motor. The proposed control method is verified by performing numerical simulations and carrying out experiments using a four‐pole, 2‐kW, 2100‐rpm IPMSM (interior permanent‐magnet synchronous motor). © 2012 Wiley Periodicals, Inc. Electr Eng Jpn, 179(3): 49–56, 2012; Published online in Wiley Online Library ( wileyonlinelibrary.com ). DOI 10.1002/eej.21246
Diffuse axonal injury due to nonmissile head injury in humans: An analysis of 45 cases (1982)

Forty-five cases of diffuse axonal injury (DAI) brought about by nonmissile head injury in humans are analyzed and compared with 132 cases of fatal head injury without DAI. All cases were subjected to a comprehensive neuropathological study. In the patients with DAI a statistically significant lower incidence of lucid interval, fracture of the skull, cerebral contusions, intracranial hematoma, and evidence of high intracranial pressure were found, with a higher incidence of head injury due to road traffic accident. Brain swelling and hypoxic brain damage were not statistically different in the two groups. The features of DAI in humans are compared with the DAI that has been produced in subhuman primates by pure inertial loading brought about by angular acceleration of the head. The available evidence indicates that DAI in human beings occurs at the time of head injury and is not due to complicating factors such as hypoxia, brain swelling, or raised intracranial pressure.
Discrete Prolate Spheroidal Sequences for compressive sensing of EEG signals (2010)

Electroencephalography (EEG) is a major tool for clinical diagnosis of neurological diseases and brain research. EEGs are often collected over numerous channels and trials, providing large data sets that require efficient collection and accurate compression. Compressive sensing (CS) emphasizing signal sparseness enables the reconstruction of signals from a small set of measurements, at the expense of computationally complex reconstruction algorithms. In this paper we show that using Discrete Prolate Spheroidal Sequences, rather than sine functions, it is possible to derive a sampling and reconstruction method which is similar to CS. Assuming non-uniform sampling our procedure can be connected with compressive sensing without complex reconstruction methods.