gebhart/patrepeval huggingface dataset:
Intracellular Localization and Functional Effects of P <sup>21</sup> -Activated Kinase-1 (Pak1) in Cardiac Myocytes (2003)

We investigated intracellular localization and substrate specificity of P21-activated kinase-1 (Pak1) in rat cardiac myocytes. Pak1 is a serine/threonine protein kinase that is activated by Rac1/Cdc42 and important in signaling of stress responses. Yet the localization and in vivo function of Pak1 in heart cells is poorly understood. Studies reported here indicate that Pak1 physically interacts with protein phosphatase 2a and localizes to the Z-disk, cell membrane, intercalated disc, and nuclear membrane of adult rat heart myocytes. We compared levels of phosphorylation of cardiac troponin I (cTnI) in control myocytes with phosphorylation of cTnI and myosin binding protein C (C-protein) in myocytes with increased Pak1 activity. The increase in activity was induced by infection of myocytes with a recombinant adenovirus (AdPak1) containing cDNA for a constitutively active Pak1. Control cells were infected with a virus (AdLacZ) containing LacZ. Basal levels of phosphorylation of cTnI and C-protein were relatively high in the myocytes infected with AdLacZ. However, phosphorylation of cTnI and C-protein in cells expressing constitutively active Pak1 was significantly reduced compared with those expressing LacZ. Measurement of Ca2+ tension relations in single myocytes demonstrated that this reduction in phosphorylation of cTnI and C-protein was associated with the predicted increase in sensitivity to Ca2+. Our data provide evidence for a novel pathway of phosphatase regulation in cardiac myocytes.
The Antifungal Drug Clotrimazole (1998)

The structure of the title compound, 1-[(2-chlorophenyl)diphenylmethyl]-1H-imidazole, C22H17ClN2, has been determined. The molecular conformation showed a weathercock-type structure and the three phenyl rings are almost perpendicular to the imidazole ring. The distances between the centres of the three phenyl rings and the centre of the imidazole ring are in the range 4.52-4.54 A.
Using test suites in evaluation of machine translation systems (1990)

Article Free AccessUsing test suites in evaluation of machine translation systems Share on Authors: Margaret King University of Geneva, Geneva University of Geneva, GenevaView Profile , Kirsten Falkedal University of Geneva, Geneva University of Geneva, GenevaView Profile Authors Info & Claims COLING '90: Proceedings of the 13th conference on Computational linguistics - Volume 2August 1990 Pages 211–216https://doi.org/10.3115/997939.997976Online:20 August 1990Publication History 8citation507DownloadsMetricsTotal Citations8Total Downloads507Last 12 Months4Last 6 weeks2 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
The HyperDisco approach to open hypermedia systems (1996)

Article The HyperDisco approach to open hypermedia systems Share on Authors: Uffe Kock Wiil Department of Computer Science, Aalborg University, Fredrik Bajers Vej 7E, 9220 Aalborg øst, Denmark Department of Computer Science, Aalborg University, Fredrik Bajers Vej 7E, 9220 Aalborg øst, DenmarkView Profile , John J. Leggett Hypermedia Research Laboratory, Department of Computer Science, Texas A&M University, College Station, Texas Hypermedia Research Laboratory, Department of Computer Science, Texas A&M University, College Station, TexasView Profile Authors Info & Claims HYPERTEXT '96: Proceedings of the the seventh ACM conference on HypertextMarch 1996 Pages 140–148https://doi.org/10.1145/234828.234842Online:01 March 1996Publication History 56citation290DownloadsMetricsTotal Citations56Total Downloads290Last 12 Months3Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
α-Synuclein overexpression increases dopamine toxicity in BE(2)-M17 cells (2010)

Our results suggest that an interplay between dopamine and alpha-synuclein can cause cell death in a neuron-like background. The data presented here are compatible with several models of cytotoxicity, including the formation of alpha-synuclein oligomers and impairment of the lysosomal degradation.
The generation of high electric field strength RF energy using Marx generators (2003)

The Wave Erection Marx Generator is proving to be an excellent high voltage source for the direct generation of RF energy. Unfortunately, effectively radiating the impulse energy is challenging, both in efficiency and high voltage-holdoff capability. Successful efforts have been made to generate RF energy in both the Narrow Band and Ultra Wideband realm, with field strengths in excess of I kV/m at 100 m achieved. This paper briefly describes the impulse generator and explores its use for generating Narrow Band RF energy as well as Ultra Wideband energy. Experimental results will be presented.
The analysis of observed chaotic data in physical systems (1993)

Chaotic time series data are observed routinely in experiments on physical systems and in observations in the field. The authors review developments in the extraction of information of physical importance from such measurements. They discuss methods for (1) separating the signal of physical interest from contamination ("noise reduction"), (2) constructing an appropriate state space or phase space for the data in which the full structure of the strange attractor associated with the chaotic observations is unfolded, (3) evaluating invariant properties of the dynamics such as dimensions, Lyapunov exponents, and topological characteristics, and (4) model making, local and global, for prediction and other goals. They briefly touch on the effects of linearly filtering data before analyzing it as a chaotic time series. Controlling chaotic physical systems and using them to synchronize and possibly communicate between source and receiver is considered. Finally, chaos in space-time systems, that is, the dynamics of fields, is briefly considered. While much is now known about the analysis of observed temporal chaos, spatio-temporal chaotic systems pose new challenges. The emphasis throughout the review is on the tools one now has for the realistic study of measured data in laboratory and field settings. It is the goal of this review to bring these tools into general use among physicists who study classical and semiclassical systems. Much of the progress in studying chaotic systems has rested on computational tools with some underlying rigorous mathematics. Heuristic and intuitive analysis tools guided by this mathematics and realizable on existing computers constitute the core of this review.
Regulation of macrophage cytokine production by phagocytosis of apoptotic and post-apoptotic cells (1998)

Conference Article| November 01 1998 Regulation of macrophage cytokine production by phagocytosis of apoptotic and post-apoptotic cells V. A. Fadok; V. A. Fadok 1 1To whom correspondence should be addressed. Search for other works by this author on: This Site PubMed Google Scholar P. P. McDonald; P. P. McDonald 1Department of Pediatrics, National Jewish Medical and Research Center, D509, 1400 Jackson Street, Denver, CO 80206, U.S.A. Search for other works by this author on: This Site PubMed Google Scholar D. L. Bratton; D. L. Bratton 1Department of Pediatrics, National Jewish Medical and Research Center, D509, 1400 Jackson Street, Denver, CO 80206, U.S.A. Search for other works by this author on: This Site PubMed Google Scholar P. M. Henson P. M. Henson 1Department of Pediatrics, National Jewish Medical and Research Center, D509, 1400 Jackson Street, Denver, CO 80206, U.S.A. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1998) 26 (4): 653–656. https://doi.org/10.1042/bst0260653 Article history Received: July 09 1998 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation V. A. Fadok, P. P. McDonald, D. L. Bratton, P. M. Henson; Regulation of macrophage cytokine production by phagocytosis of apoptotic and post-apoptotic cells. Biochem Soc Trans 1 November 1998; 26 (4): 653–656. doi: https://doi.org/10.1042/bst0260653 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: GM-CSF, granulocyte-macrophage colony stimulating factor, LPS, lipopolysaccharide, TGF, transforming growth factor, IL, interleukin, TNF, tumour necrosis factor, PS, phosphatidylserine This content is only available as a PDF. © 1998 Biochemical Society1998 Article PDF first page preview Close Modal You do not currently have access to this content.
Role of Vascular Endothelial Cell Growth Factor in Ovarian Hyperstimulation Syndrome (1999)

Levin, Ellis R.; Rosen, Gregory F.; Cassidenti, Denise L.; Yee, Bill; Meldrum, David; Wisot, Arthur; Pedram, Ali Author Information
On the Riccati difference equation for stochastic realization (2009)

This paper studies the asymptotic behavior of the solution to the Riccati difference equation for stochastic realization [1] as the time progresses, by using the results of[2]. It is alternatively proved that the solution to the Riccati difference equation converges to the stabilizing solution to the steady state Riccati equation. Numerical simulation results are also included.
The Cachexia Clinic: From Staging to Managing Nutritional and Functional Problems in Advanced Cancer Patients (2012)

Panels of experts have agreed on the definition of cancer cachexia stages (CCS). We evaluated the clinical relevance of these stages and proposed ways to apply the CCSs to the clinical practice via standardized methods. The CCS were applied to 207 patients with advanced non-small-cell lung or gastrointestinal cancers from the Human Cancer Cachexia Database via consensus among the coauthors. Patients were categorized as noncachectic, precachectic, cachectic, and in refractory cachexia. Through analysis of variance, χ2, and Kaplan-Meier analyses, we tested the relationships between CCSs and selected outcomes. The CCS were significantly correlated (P < 0.05) with patient-centered indicators, including overall symptom burden, quality of life, tolerability to chemotherapy, body composition, hospital stay, and survival. However, precachectic and cachectic patients behaved similarly in all these outcomes but were significantly different from noncachectic and refractory cachectic patients. The average scores for the abridged Patient-Generated Subjective Global Assessment (aPG-SGA) corresponded well with the CCSs and reflected nicely the cut-off scores recommended for the nutritional triage of cancer patients. In addition to the aPG-SGA, we proposed the Edmonton Symptom Assessment System and routine laboratory tests for the triage of patients with refractory cachexia, for whom comfort care is the primary goal. The cachexia clinic hosted by the McGill Nutrition and Performance Laboratory offers a model for diagnosing more precisely the pathophysiology and severity of precachectic and cachectic conditions. The cachexia clinic, by working closely with palliative care programs, may offer the best environment for a comprehensive and personalized approach to the nutritional and functional problems in advanced cancer patients.
Ganglioside composition is regulated during differentiation in the neuroblastoma X glioma hybrid cell line NG108-15 (1983)

Cellular differentiation of the neuroblastoma X glioma hybrid cell line NG108-15 was measured and correlated with quantitative changes in the cells' ganglioside composition. The degree of differentiation was measured using an enzymatic marker, choline acetyltransferase (CAT), which is responsible for neurotransmitter synthesis in this cell line. Differentiation of these cells is commonly induced by agents such as dibutyryl cyclic adenosine 3':5'-monophosphate (Bt2cAMP). However, in our studies, we observed that these cells "self-differentiated," in the absence of chemical inducers, when the cells became dense in culture. The differentiation marker, CAT specific activity, rose from 150 to more than 400 pmol/min/mg of protein as cell density increased, attaining a level higher than that achieved by treatment with Bt2cAMP. Differentiation of sparse cultures could be induced by conditioned medium removed from dense cultures. This effect was not due to depletion of a serum component from the medium by the cells, since it was not mimicked by serum depletion or inhibited by addition of fresh serum to the conditioned medium. These data suggest that cell density-dependent differentiation was caused by release of a factor from the cells which induced differentiation in a concentration-dependent manner. Gangliosides, therefore, were purified from sparse control cultures, dense cultures, and cultures treated with the differentiating agents Bt2cAMP, prostaglandin E1 (plus theophylline), or butyric acid. Quantitative thin layer chromatography revealed that all of the cultures contained the four gangliosides GM3, GM2, GM1, and GD1a. The concentration of one of the gangliosides, GM2, increased markedly (up to 12-fold) during differentiation. The GM2 concentration correlated closely with the level of CAT activity in the different cultures (r = 0.99). These data demonstrate that the ganglioside concentration in these cells is regulated during differentiation, a finding consistent with a possible role for gangliosides in the differentiated phenotype.
Detection of off gassing from Li-ion batteries (2013)

Off gas from Li-ion batteries is becoming a growing concern because the volatile organics emitted are flammable and their unpredictable release represents a safety risk. Recent safety incidents involving Li-based battery chemistries have occurred across automotive, marine, electric grid, and aviation sectors and indicate a need to understand battery failure and the implications for control of the thermal event and the off gas hazard. The work presented summarizes the early results of an ARPA-e AMPED funded study (2012-2015) to qualify a novel sensor for off gas detection. Early results indicate the sensor can detect off gas prior to thermal events. The remainder of the program will address whether the sensor can detect off gas prior to significant failure events and whether battery functionality can be preserved after abuse events. In addition, with enough prior warning from the sensor there is a desire to determine whether it provides suitable control at the fringes of battery performance and also acts as a state of health sensor. The implications for off gas monitoring will be investigated in several contexts including life extension, second life batteries, and the use of batteries in new environments with varying safety considerations.
A cell adhesion peptide from foot-and-mouth disease virus can direct cell targeted delivery of a functional enzyme (1998)

The G-H loop of foot-and-mouth disease virus is a disordered protrusion of the VP1 protein exposed on the virion surface. This short stretch includes an arginine-glycine-aspartic acid tripeptide, a recognized integrin-binding motif, which is responsible for cell attachment and infection. Eight copies of a peptide reproducing the amino acid sequence of this FMDV ligand have been displayed in solvent-exposed regions on an enzymatically active recombinant beta-galactosidase. This viral peptide segment enables the chimeric enzyme to bind mammalian cell lines with different efficiencies, probably depending on the number of suitable cell receptors present on each of them. Moreover, it also promotes the internalization of the attached enzyme, which is transiently active inside the cells. These results suggest further exploration of the potential use of short adhesion peptides of viral origin as cell attachment tags to direct the targeted delivery of both genes and enzymes, instead of whole, infectious viruses.
Quantitative Conformationally Sampled Pharmacophore for δ Opioid Ligands:  Reevaluation of Hydrophobic Moieties Essential for Biological Activity (2007)

Recent studies have indicated several therapeutic applications for delta opioid agonists and antagonists. To exploit the therapeutic potential of delta opioids developing a structural basis for the activity of ligands at the delta opioid receptor is essential. The conformationally sampled pharmacophore (CSP) method (Bernard et al. J. Am. Chem. Soc. 2003, 125, 3103-3107) is extended here to obtain quantitative models of delta opioid ligand efficacy and affinity. Quantification is performed via overlap integrals of the conformational space sampled by ligands with respect to a reference compound. Iterative refinement of the CSP model identified hydrophobic groups other than the traditional phenylalanine residues as important for efficacy and affinity in DSLET and ICI 174 864. The obtained models for a structurally diverse set of peptidic and nonpeptidic delta opioid ligands offer good predictions with R2 values>0.9, and the predicted efficacy for a set of test compounds was consistent with the experimental values.
Oligonucleotide Therapeutics: A Step Forward (2000)

Article Tools EDITORIAL Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2000.18.9.1809 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 10784620 Oligonucleotide Therapeutics: A Step Forward Alan M. Gewirtz, MDxAlan M. GewirtzSearch for articles by this author Show More University of Pennsylvania, School of Medicine, Philadelphia, PA https://doi.org/10.1200/JCO.2000.18.9.1809 First Page Full Text PDF Figures and Tables © 2000 by American Society of Clinical Oncology
Neural Networks for Text Correction and Completion in Keyboard Decoding (2017)

Despite the ubiquity of mobile and wearable text messaging applications, the problem of keyboard text decoding is not tackled sufficiently in the light of the enormous success of the deep learning Recurrent Neural Network (RNN) and Convolutional Neural Networks (CNN) for natural language understanding. In particular, considering that the keyboard decoders should operate on devices with memory and processor resource constraints, makes it challenging to deploy industrial scale deep neural network (DNN) models. This paper proposes a sequence-to-sequence neural attention network system for automatic text correction and completion. Given an erroneous sequence, our model encodes character level hidden representations and then decodes the revised sequence thus enabling auto-correction and completion. We achieve this by a combination of character level CNN and gated recurrent unit (GRU) encoder along with and a word level gated recurrent unit (GRU) attention decoder. Unlike traditional language models that learn from billions of words, our corpus size is only 12 million words; an order of magnitude smaller. The memory footprint of our learnt model for inference and prediction is also an order of magnitude smaller than the conventional language model based text decoders. We report baseline performance for neural keyboard decoders in such limited domain. Our models achieve a word level accuracy of $90\%$ and a character error rate CER of $2.4\%$ over the Twitter typo dataset. We present a novel dataset of noisy to corrected mappings by inducing the noise distribution from the Twitter data over the OpenSubtitles 2009 dataset; on which our model predicts with a word level accuracy of $98\%$ and sequence accuracy of $68.9\%$. In our user study, our model achieved an average CER of $2.6\%$ with the state-of-the-art non-neural touch-screen keyboard decoder at CER of $1.6\%$.
Contributing to the development of Linguistic and Logical Abilities through Robotics (2007)

For children in primary schools, programming small robots is an amusing way to be introduced to technological activities. Core of our project is NQCBaby, an Italian based LOGO like language, pupil oriented rather than robot oriented: indeed concepts are used from the child world. S. Papert said:”small robots programmed in LOGO language ” [1993]. We had robots, but we had’t a LOGO for robots. So, we want NQCBaby looks similar to Logo so that children already introduced to turtles feel at ease with robots and interestingly discuss on differences. In our activities pupils begin using a very simple language, the essence of NQCBaby, to interact with the simplest robot RCX and then progress to an enriched language as their assembly experiences advance. The constructive pedagogical methodology (and consequently our tools) structures pupils ’ learning of NQCBaby language in several steps starting with NQCBaby01 up to NQCBaby05, as new hardware components are introduced to build different robots. Meanwhile children are introduced to NQC, the “true ” robot language, by looking at how their descriptions of the robots behaviors are translated in NQC, “in order to be understood”. This step-by-step learning activity is coordinated with children knowledge of their native language thus helping a correct development of linguistic and logical abilities in their first steps. A software environment, based on a precompiler from NQCBaby to NQC, is currently being developed for supporting the project principles where learning evolves from NQCBaby01 to NQCBaby05. do NOT use any Footer – it will be added by us later EuroLogo 2007 header – do not use it, it will be added by us Figure 1. Children assemble a robot, decide a behaviour, describe it in NQCBabyh, and look at the resulting definition in NQC; then they enter the next step to learn the next level NQCBabyh+1
Characterization of <i>Lapis Lazuli</i> Pigments Using a Multitechnique Analytical Approach: Implications for Identification and Geological Provenancing (2009)

Many of the Raman spectra obtained from areas painted with ultramarine pigments in illuminated manuscript leaves from the 14th century Italian manuscript the Laudario of Sant'Agnese, in the collection of the J. Paul Getty Museum, also contain strong bands not typically associated with this pigment. The source of these features was investigated using a multitechnique analytical approach. Techniques employed include Raman microspectroscopy, scanning electron microscopy with energy-dispersive spectroscopy, electron probe microanalysis, and laser ablation inductively coupled plasma mass spectrometry. The results indicate the presence of diopside (CaMgSi(2)O(6)), a mineral commonly associated with lapis lazuli in nature, and suggest that transition metal dopants in the diopside may be responsible for the Raman features, likely the result of fluorescence with vibronic coupling. The implication of this result with respect to using Raman spectroscopy as a fast, noninvasive, and nondestructive method for determining the geological provenance of natural lapis lazuli pigments used in art is discussed.