gebhart/patrepeval huggingface dataset:
Bioeffective monoclonal antibody against the decapeptide gonadotropin-releasing hormone: reacting determinant and action on ovulation and estrus suppression. (1985)

A monoclonal antibody generated against the decapeptide gonadotropin-releasing hormone (GnRH) was effective in intercepting the bioactivity of the hormone; it blocked ovulation in rats. The antibody reacted optimally with the native hormone. Substitution of amide at the COOH terminus by a carboxyl group decreased immunoreactivity by a factor of 200. The antibody recognized the amino acid sequences 4-6, 7-10, and 4-10 to a variable degree, which suggests that the epitope has a conformation involving the entire molecule, with the NH2- and COOH-terminal regions probably in proximity. The antibody was also competent to suppress the progression of estrus in dogs, an indication that GnRH may play an inductive role in the reproductive function of dogs.
Near-misses are an opportunity to improve patient safety (2015)

Health care organizations should consider near-misses as opportunities for quality improvement. The systematic reporting and analysis of near-misses, commonplace in HROs, can be adapted to health care settings to prevent adverse events and improve clinical outcomes.
Are there more tricks in the bag for treating thrombocytopenia? (2010)

Thrombocytopenia, an abnormally low number of circulating platelets, results from inadequate platelet production, splenic platelet sequestration, or accelerated platelet clearance. Platelet transfusions are now the cornerstone for treating thrombocytopenia. With an ever-expanding demand for platelets, and with many patients having an inadequate response to platelet transfusions, new strategies are needed to treat thrombocytopenia. In this issue of the JCI, Fuentes et al. present provocative data regarding the use of direct megakaryocyte infusions as a novel approach to manage this vexing clinical problem.
Histidine-rich glycoprotein: the Swiss Army knife of mammalian plasma (2010)

Histidine-rich glycoprotein (HRG), also known as histidine-proline-rich glyco-protein, is an abundant and well-characterized protein of vertebrate plasma. HRG has a multidomain structure that allows the molecule to interact with many ligands, including heparin, phospholipids, plasminogen, fibrinogen, immunoglobulin G, C1q, heme, and Zn²(+). The ability of HRG to interact with various ligands simultaneously has suggested that HRG can function as an adaptor molecule and regulate numerous important biologic processes, such as immune complex/necrotic cell/pathogen clearance, cell adhesion, angiogenesis, coagulation, and fibrinolysis. The present review covers the proposed multifunctional roles of HRG with a focus on recent findings that have led to its emergence as a key regulator of immunity and vascular biology. Also included is a discussion of the striking functional similarities between HRG and other important multifunctional proteins found in plasma, such as C-reactive protein, C1q, β₂ glycoprotein I, and thrombospondin-1.
Competing discrete interfacial effects are critical for amyloidogenesis (2009)

Amyloid accumulation is associated with pathological conditions, including type II diabetes and Alzheimer's disease. Lipids influence amyloidogenesis and are themselves targets for amyloid-mediated cell membrane disruption. Amyloid precursors are surface-active, accumulating at hydrophobic-hydrophilic interfaces (e.g., air-water), where their biophysical and kinetic behaviors differ from those in the bulk solution with significant and underappreciated consequences. Biophysical modeling predicted the probability and rate of beta-sheet amyloid dimer formation to be higher and faster at the air-water interface (AWI) than in the bulk (by 14 and approximately 1500 times, respectively). Time-course staining experiments with a typical amyloid dye verified our predictions by demonstrating that without AWI, islet amyloid polypeptide (IAPP) fibrilization was abolished or slowed, depending on the conditions. Our controls included undisturbed IAPP reactions, and we ascertained that the AWI removal process (technical or material) did not itself affect the reaction. Furthermore, we showed that the role of membranes in amyloidogenesis has been previously underestimated; in an in vivo-like situation (with no AWI), anionic liposomes (containing dioleoylphosphatidylglycerol) enhanced IAPP fibrilogenesis far more than described previously in conventional assay conditions (in the presence of an AWI). These findings have implications for the protein misfolding field and in assay design to target toxic protein aggregation.
Applications of environmental geophysical methods in China's environmental monitoring (2011)

With China's rapid economic development, serious environment pollution has affected China's economic and social sustainable development. Environmental geophysics was widely applied and playing an increasingly important role in monitoring environment pollution for its unique advantage. With the aggravation of environment pollution and the development of geophysical techniques, the application of environmental geophysical methods is becoming more and more extensive in monitoring and controlling environmental pollution. It has become an indispensable tool to deal with environment pollution in China.
Treatment of Acute Carbon Monoxide Poisoning with Extracorporeal Membrane Trioxygenation (2012)

Objective To treat acute carbon monoxide poisoning (ACOP) with extracorporeal membrane trioxygenation (ECMO 3 ), and to determine the efficacy and safety of ECMO 3 . Method Thirty-two New Zealand white rabbits were divided randomly into four groups including ECMO 3 group (G1-ECMO 3 ) oxygen treatment group (G2–FIO 2 ), untreated ACOP group (G3-ACOP), and control group (G4-control). Rabbits in the first three groups were intraperitoneally injected with 99.99% CO at a dosage of 200 ml/kg, and those in the control group were treated with placebo. The dynamic changes in carboxyhemoglobin (COHb) concentration, blood oxygen saturation (SO 2 ) level, base excess of blood (BE-B) as well as the vital signs of the rabbits were monitored. Results All the experimental rabbits had significantly higher levels of COHb (p = 0.000<0.05) than those in the control group after 30 min of CO injection with poisoning reactions. The respiration and heart rate of the rabbits in the ECMO 3 group and FIO 2 group were recovered to a level close to those of the rabbits in the control group by the end of the treatment, and they were significantly lower than those in the ACOP group (p = 0.000, <0.05). The COHb levels of rabbits in the G1–ECMO 3 group were significantly lower than those in the G2-FIO 2 and the G3-ACOP groups (F = 42.799, p = 0.000), and were similar to those in the control group. After 0.5 h of treatment, the SO 2 and BE-B levels of rabbits in the G1-ECMO 3 and the G2-FIO 2 groups were higher than those in the G3-ACOP group (p<0.05, p = 0.000<0.05). Conclusions ECMO 3 treatment effectively lowered the COHb levels, increased SO 2 levels, and cured acid poisoning, making it a safe and promising ACOP treatment strategy.
Efficient Photodetection at IR Wavelengths by Incorporation of PbSe–Carbon‐Nanotube Conjugates in a Polymeric Nanocomposite (2007)

PbSe quantum dots (QDs) are conjugated onto the surface of single-walled carbon nanotubes by a novel ligation procedure. The nanotubes are first surface-functionalized with thiol groups, which enable the adhesion of large numbers of colloidally prepared PbSe QDs. Polymeric nanocomposite IR photosensitizers made from these conjugate structures (see figure) generate significantly enhanced (≥ 100 %) IR photocurrents compared to devices using only QDs.
MPEG-2: a tutorial introduction to the systems layer (1995)

The MPEG-2 systems specification describes how MPEG-compressed video and audio data streams may be multiplexed together to form a single data stream. This paper aims to introduce the jargon and the fundamental principles of the MPEG-2 systems layer. Two alternative multiplexing methods are specified for the MPEG-2 systems layer. The stream is biased towards the storage and replay of a single programme from a digital storage device while the transport stream is intended for the simultaneous delivery of a number of programmes over potentially error-prone channels. Both methods facilitate the inclusion of programme specific information detailing the programme(s) and elementary streams present. Both methods use a system of time stamps and clock references to ensure the synchronous replay of related elementary streams and correct buffer behaviour at a decoder. There are many optional syntax elements and many opportunities to include private (user-defined) syntax extensions enabling either multiplexing to be optimised to suit a particular application.
Preparation and evaluation of packed capillary liquid chromatography columns with inner diameters from 20 to 50 micrometers (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation and evaluation of packed capillary liquid chromatography columns with inner diameters from 20 to 50 micrometersRobert T. Kennedy and James W. JorgensonCite this: Anal. Chem. 1989, 61, 10, 1128–1135Publication Date (Print):May 15, 1989Publication History Published online1 May 2002Published inissue 15 May 1989https://pubs.acs.org/doi/10.1021/ac00185a016https://doi.org/10.1021/ac00185a016research-articleACS PublicationsRequest reuse permissionsArticle Views1121Altmetric-Citations267LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Discrimination of Nitroaromatics and Explosives Mimics by a Fluorescent Zn(salicylaldimine) Sensor Array (2008)

Detecting and identifying components of plastic explosive devices is a challenge to current optical sensing methods. We report a fluorescent Zn(salicylaldimine) sensor array that accurately discriminated nitroaromatics, which are mimics of plastic explosives. Nitroaromatics quench the fluorescence of Zn(salicylaldimine), with differential quenching for the various fluorophore/quencher partners. The response pattern of the Zn(salicylaldimine) array created unique fingerprints for each of the nine nitroaromatic analytes tested, including unique responses for dinitrotoluene and dinitrobenzene. Linear discriminant analysis showed that the discrimination is largely due to a combination of two physical properties of the nitroaromatics: redox potential and log P. The array was able to discriminate unknown nitroaromatic samples in solution.
A phytochrome from the fern <i>Adiantum</i> with features of the putative photoreceptor NPH1 (1998)

In plant photomorphogenesis, it is well accepted that the perception of red/far-red and blue light is mediated by distinct photoreceptor families, i.e., the phytochromes and blue-light photoreceptors, respectively. Here we describe the discovery of a photoreceptor gene from the fern Adiantum that encodes a protein with features of both phytochrome and NPH1, the putative blue-light receptor for second-positive phototropism in seed plants. The fusion of a functional photosensory domain of phytochrome with a nearly full-length NPH1 homolog suggests that this polypeptide could mediate both red/far-red and blue-light responses in Adiantum normally ascribed to distinct photoreceptors.
Novel amplification unit at chromosome 3q25-q27 in human prostate cancer (2000)

Our studies revealed a novel amplification unit at 3q25-q27 in prostate carcinoma, with the genes IL12A, MDS1, SLC2A2, and SOX2 being located within the amplification unit. A common region of amplification was evident spanning the IL12A gene locus at 3q25-q26.2. Possibly, IL12A indicates an adjacent, till now unidentified gene which is important in the development of prostate cancer.
Modeling metastasis biology and therapy in real time in the mouse lung (2010)

Pulmonary metastasis remains the leading ca use of death for cancer patients. Opportunities to improve treatment outcomes for patients require new methods to study and view the biology of metastatic progression. Here, we describe an ex vivo pulmonary metastasis assay (PuMA) in which the metastatic progression of GFP-expressing cancer cells, from a single cell to the formation of multicellular colonies, in the mouse lung microenvironment was assessed in real time for up to 21 days. The biological validity of this assay was confirmed by its prediction of the in vivo behavior of a variety of high- and low-metastatic human and mouse cancer cell lines and the discrimination of tumor microenvironments in the lung that were most permissive to metastasis. Using this approach, we provide what we believe to be new insights into the importance of tumor cell interactions with the stromal components of the lung microenvironment. Finally, the translational utility of this assay was demonstrated through its use in the evaluation of therapeutics at discrete time points during metastatic progression. We believe that this assay system is uniquely capable of advancing our understanding of both metastasis biology and therapeutic strategies.
Carbon Source Regulation of PIS1 Gene Expression in Saccharomyces cerevisiae Involves the MCM1 Gene and the Two-component Regulatory Gene, SLN1 (1996)

The Saccharomyces cerevisiae PIS1 gene encodes phosphatidylinositol synthase. The amount of phosphatidylinositol synthase is not affected by the presence of inositol and choline in the growth medium. This is unusual because the amounts and/or activities of other phospholipid biosynthetic enzymes are affected by these precursors, and the promoter of the PIS1 gene contains a sequence resembling the regulatory element that coordinates the inositol-mediated regulation (UASINO). We found that transcription of the PIS1 gene was insensitive to inositol and choline and did not require the putative UASINO regulatory sequence or the cognate regulatory genes (INO2 and OPI1). The PIS1 promoter includes sequences (MCEs) that bind the Mcm1 protein. Because the Mcm1 protein interacts with both the Sln1 and the Gal11 regulatory proteins, we examined the effect of mutant alleles of the MCM1 and SLN1 genes and carbon source on expression of the PIS1 gene. We found that expression of the PIS1 gene was reduced when cells were grown in a medium containing glycerol and increased when grown in a medium containing galactose relative to cells grown in a glucose medium. The glycerol-mediated repression of PIS1 gene expression required both the MCM1 gene and the MCEs, whereas the SLN1 gene was required for full galactose-mediated induction of a PIS1-lacZ reporter gene. Thus, PIS1 gene expression is unique among the phospholipid biosynthetic structural genes because it is uncoupled from the inositol response and regulated in response to the carbon source. This is the first example in yeast of a complete circuit linking a stimulus (carbon source) to gene regulation (PIS1) using a two-component regulator (SLN1).
Chemical Solid Free-Form Fabrication:  Making Shapes without Molds (1997)

Solid free-form fabrication methods are surveyed. This approach of making objects by depositing material layer by layer lends itself to the direct conversion of fluid reactants to a solid part, as opposed to the production of a material and its subsequent processing. Examples are given of the formation of ceramics, metals, thermoplastics, thermosets, and composites. In principle, mobile products can be removed from the layers as they form, allowing a much wider range of reactions to be used. Since the composition may be varied as the object is built up, it is also possible to combine several materials into a monolithic piece.
Effect of a Nitroglycerin Patch on Perfusion to the Foot in Healthy Subjects (2006)

Nitric oxide is an endogenous gas released by endothelial cells that induces vasodilatation and plays other important roles in the wound-healing process. Nitroglycerin preparations are liberators of nitric oxide. Podiatric physicians have used nitroglycerin paste and patches on patients in an attempt to increase perfusion to the foot. However, the drug's efficacy seems to be largely anecdotal. A prospective, randomized, placebo-controlled, double-blind study was conducted to investigate the efficacy of a nitroglycerin patch in locally increasing perfusion to the foot. Twenty-two healthy subjects were randomly assigned to either a drug group (nitroglycerin patch, 0.2 mg/h) or a placebo group (adhesive patch without active ingredient). The patch was applied to the plantar arch of the foot. Objective and subjective measures were then used to detect changes in perfusion to the foot after a 2-hour experimental period. The objective measures, cutaneous thermometry and photoplethysmography, found no significant measurable difference in perfusion to the foot between the drug and placebo groups (P > .05). A subjective questionnaire used to assess changes in temperature or sensation detected by the subject yielded similar results. Thus a nitroglycerin patch dose of 0.2 mg/h showed no measurable ability to increase perfusion to the foot. Further research is needed to validate the indications for this therapy.
Computer-aided diagnosis of mammographic masses using vocabulary tree-based image retrieval (2014)

Computer-aided diagnosis of masses in mammograms is important to the prevention of breast cancer. Many approaches tackle this problem through content-based image retrieval (CBIR) techniques. However, most of them fall short of scalability in the retrieval stage, and their diagnostic accuracy is therefore restricted. To overcome this drawback, we propose a scalable method for retrieval and diagnosis of mam-mographic masses. Specifically, for a query mammographic region of interest (ROI), SIFT descriptors are extracted and searched in a vocabulary tree, which stores all the quantized descriptors of previously diagnosed mammographic ROIs. In addition, to fully exert the discriminative power of SIFT descriptors, contextual information in the vocabulary tree is employed to refine the weights of tree nodes. The retrieved ROIs are then used to determine whether the query ROI contains a mass. This method has excellent scalability due to the low spatial-temporal cost of vocabulary tree. Retrieval precision and diagnostic accuracy are evaluated on 5005 ROIs extracted from the digital database for screening mammography (DDSM), which demonstrate the efficacy of our approach.
Deposition and clearance of monodisperse aerosols in the calf lung: effects of particle size and a mucolytic agent (bromhexine) (1987)

Mucociliary clearance and retention of monodisperse aerosols of radiolabelled polystyrene particles of both 3.3 microns and 5 microns diameter were investigated in four healthy calves and two sick calves. The effect of the mucolytic agent bromhexine was also assessed at two dosage levels. There were significant differences (P less than 0.05) in clearance rate constant between calves, but similar patterns of clearance for each calf. These characteristics of mechanical lung clearance did not vary over a two month period. Values of clearance rate constant and percentage retention varied significantly (P less than 0.001) between the two different particle sizes, 5 microns particles giving faster clearance and lower retention of particles than 3.3 microns particles. Bromhexine at the recommended dose of 1.6 mg/kg 0.75 caused a significant (P less than 0.05) increase in clearance rate in both healthy and sick calves, but affected percentage retention only in sick calves. This study illustrates the variation in mucociliary clearance rates shown by individuals and also underlines the importance of particle size in aerosols used for studies of pulmonary deposition and clearance. The work also indicates that bromhexine may be of use in the therapy of respiratory disease in calves.
HYPERTENSION IN HEMODIALYSIS PATIENTS: Cardiac Consequences of Hypertension in Hemodialysis Patients (2004)

Hypertension in end-stage renal disease (ESRD) is an important risk factor for left ventricular hypertrophy (LVH), cardiac failure, coronary artery disease (CAD), and arrhythmia. LVH is generally considered an integrator of the long-term effects of hypertension and other cardiovascular (CV) risk factors and represents the strongest predictor of adverse CV outcomes in ESRD patients. The risk of heart failure is higher in patients with a history of hypertensive renal disease than in those with other diagnoses. Both coronary heart disease (CHD) and LVH predict congestive heart failure, which is often the ultimate cause of death in patients with cardiac ischemia or LVH. A history of long-standing hypertension is associated with ischemic heart disease both in cross-sectional and prospective studies in ESRD. Atrial fibrillation and ventricular arrhythmias are highly prevalent in dialysis patients and are implicated in mortality and sudden death in this population. Despite the lack of evidence from randomized controlled trials, it appears reasonable that interventions aimed at curbing the high CV mortality of ESRD should be targeted to both hypertension and LVH.
Sønderjylland 1931. (1933)

Alnor udsendte 21 Kort om Valg, Sindelag
Centrally administered orexin/hypocretin activates HPA axis in rats (2000)

The effects of i.c.v. administration of orexin/hypocretin on plasma ACTH, corticosterone and c-fos mRNA in the paraventricular nucleus (PVN) of the rat were examined. Plasma ACTH levels were markedly increased at 30 min after i.c.v. administration of orexin-A. Plasma corticosterone levels were significantly increased in a dose-related manner 30 min after i.c.v. administration of orexin-A and orexin-B. In situ hybridization histochemistry revealed that the induction of the c-fos mRNA in the parvocellular division of the PVN was increased in a dose-related manner 30 min after i.c.v. administration of orexin-A and orexin-B. These results suggest that central orexin/hypocretin activates hypothalamo-pituitary-adrenal (HPA) axis and may be involved in stress-induced activation of the HPA axis.
Fluorine-enhanced Pt/ZSM-5 catalysts for low-temperature oxidation of ethylene (2018)

Fluorine treatment enhances the catalytic performance of Pt/ZSM-5 for ethylene low-temperature oxidation due to its increased Brønsted acidity and water tolerance.