gebhart/patrepeval huggingface dataset:
Complete Atrio-ventricular Block as a Major Clinical Presentation of the Primary Cardiac Lymphoma: a Case Report (2001)

It is uncommon for malignant lymphomas to present primarily with cardiac invasion as the main clinical feature. What we are interested in is not only where the disease is, but also those symptoms that it may induce. Sudden onset of complete atrio-ventricular block is one of the most common clinical presentations. Cardiac tamponade is another common disease entity which, if it locates over outlets of great vessels, may also exert symptoms of obstructive vessels. Diagnosis can be made by needle aspiration under the guidance of transcutaneous or transesophageal echocardiography. Both CT scan and MRI play positive roles in the diagnosis of cardiac lymphomas, and the latter can even provide much more image information than the former. We report a 70-year-old male with primary cardiac lymphoma with initial clinical pictures of sudden onset of complete atrio-ventricular block. Chemotherapy was utilized with cyclophosphamide, vincristine and prednisolone (COP) initially for four courses and followed by adding doxorubicin (CHOP) for another three courses. The patient was still in remission status after treatment for 2 years.
Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis (2009)

Age-related hearing loss (AHL), known as presbycusis, is a universal feature of mammalian aging and is the most common sensory disorder in the elderly population. The molecular mechanisms underlying AHL are unknown, and currently there is no treatment for the disorder. Here we report that C57BL/6J mice with a deletion of the mitochondrial pro-apoptotic gene Bak exhibit reduced age-related apoptotic cell death of spiral ganglion neurons and hair cells in the cochlea, and prevention of AHL. Oxidative stress induces Bak expression in primary cochlear cells, and Bak deficiency prevents apoptotic cell death. Furthermore, a mitochondrially targeted catalase transgene suppresses Bak expression in the cochlea, reduces cochlear cell death, and prevents AHL. Oral supplementation with the mitochondrial antioxidants alpha-lipoic acid and coenzyme Q(10) also suppresses Bak expression in the cochlea, reduces cochlear cell death, and prevents AHL. Thus, induction of a Bak-dependent mitochondrial apoptosis program in response to oxidative stress is a key mechanism of AHL in C57BL/6J mice.
Analgesic activity and opiate receptor affinity of new derivatives of N-butylpiperidine. (1981)

The three newly synthesized derivatives of N-butylpiperidine 1-butyl-4-phenyl-4-isonicotinoylaminoethylpiperidine (BG 25), 1-buty-isonicotinoylpiperidine (BG 26) and N-(1-butyl-4-phenyl-4-piperidinoyl) tetrahydropapaverine (BG 9) were evaluated for analgesic activity and opiate receptor affinity. All the three compounds showed analgesic activity both in hot-plate and flinch-squeak-jump test in mice, BG 9 being the most potent. The affinity of the compounds to opiate receptor was moderate (in comparison with pentazocine): the affinity of BG 9 was much greater than that of BG 25 and BG 26. The compounds showed a pronounced inhibitory action in stimulated guinea-pig ileum preparation; this was reversible by naloxone. As evaluated on pA basis, all three investigated compounds showed moderate antagonistic activity. Also in this respect BG 9 was more active than the other two compounds. Cholinolytic and strong spasmolytic properties were observed in isolated rat ileum preparation for BG 9 only.
<b>Aortoiliac Kissing Stents:</b>Long-term Results and Analysis of Risk Factors Affecting Patency (2006)

Implantation of kissing stents is a safe and effective alternative in the treatment of aortoiliac obstructions. However, overall primary and assisted primary patency rates are inferior to those reported for surgery. Long-term patency comparable to surgery may be obtained in patients >50 years and in those without an iliac occlusion, particularly if a favorable stent configuration is achieved.
In situ identification of azo dye inhibition effects on nitrifying biofilms using microelectrodes (2002)

In this study, the inhibitory effects of acid orange 7 (AO7), a common azo dye, on nitrification in biofilms were investigated in situ using microelectrodes. Biofilms were obtained from laboratory rotating drum biofilm reactor after the nitrification process reached a pseudo-steady state. Dissolved oxygen, pH, NH4+, NO3-, and redox potential microelectrodes, with tip diameters ranging from 3-15 microm, were used to monitor the spatial distribution and change of microbial activities within nitrifying biofilms. It was found that at lower concentration (1 mg/L), AO7 had only a slight impact on the NH4+-N concentration profiles. The ammonium consumption rate decreased as higher AO7 concentrations (15 mg/L and 25 mg/L) were exposed to the biofilms. A similar trend was observed for the NO3(-)-N microprofiles. The nitrate production rate decreased as the AO7 concentration in the bulk solution increased. The dissolved oxygen and pH microprofiles also showed oxygen and alkalinity utilization, but at lower rates throughout the biofilms when the nitrification process was inhibited. No significant redox potential differences were observed in the biofilms after AO7 was applied.
WDM-PON Fiber-Fault Automatic Detection and Localization with 1 dB Event Sensitivity in Drop Links (2012)

Trial of live WDM-PON monitoring based on Optical Time Domain Reflectometry (OTDR) and Optical Transceiver Monitoring (OTM) is presented. The concept of cost-effective, remote and quick operation without drop-line demarcation components is demonstrated.
Silicon MCM-D technology for RF integration (2002)

The thin film implementation of Multichip Module technology has been identified as a useful platform for the integration of GaAs MMICs and silicon device technologies for microwave applications where performance, size and weight are critical factors. The ability of the MCM-D technology to provide controlled impedance, microstrip structures and integrated thin film passive components with useful performances in the microwave frequency regime has now been demonstrated. This paper describes the 3 layer metallisation MCM-D technology developed by GPS for RF integration applications and reviews the range of integrated passive resistor, capacitor and inductor components that may be defined within the substrate structure. Representative equivalent circuit models for these components are discussed. Examples of novel multilayer microwave components that may be realised in this MCM-D technology, including multilayers spiral inductors and transmission line transformers, are also cited. The design route for RF module simulation and design is outlined. Examples of typical RF MCM-D functional block designs are presented and their performance illustrated. Results are presented for MCM filters and for a Low Noise Amplifier (LNA) block designed for the HIPERLAN band at 5.2 GHz. Examples of more complex, mixed technology RF MCM designs are also presented, including a 2.1 GHz VCO module and a complete RF front end module solution for the HIPERLAN band at 5.2 GHz.
Mean platelet volume is a useful parameter: a reproducible routine method using a modified Coulter Thrombocytometer (2000)

The principal physiological function of platelets is to promote haemostasis but they also contribute to thrombosis and atherogenesis. Platelet volume is a marker and possibly a determinant of platelet function in that large platelets are more active than normal sized platelets. Mean platelet volume (MPV), a measure of platelet size, reflects changes in either the level of platelet stimulation or the rate of platelet production. For these reasons, we have developed a sensitive instrument to measure platelet volume, which we believe is more reliable and specific than previously used instruments. It is based on a computer-interfaced Coulter Thrombocytometer and a pulse analyser including a high-speed baseline restorer. We have developed a reproducible method to assay MPV and from the histogram derived the median (MED) and the skewness (SK) values. We have looked at the effects of anticoagulant used and time elapse prior to assay. A normal range has been established for MPV which correlates directly with MED and inversely with SK. The MPV decreases with age but there is no difference between genders. We have demonstrated a negative correlation between whole blood platelet number and MPV and MED, and a direct relationship with the SK of the histogram of the platelet volume.
Estimación de la incertidumbre de la medición para la determinación de proteínas en alimentos por el método de Kjeldahl (2011)

Resumen es: En la evaluacion de los alimentos, la determinacion de proteinas resulta de gran utilidad para el sector agroindustrial porque a traves de ella se puede ...
Psychological Contract Violation in Online Marketplaces: Antecedents, Consequences, and Moderating Role (2005)

This study examines the nature and role of Psychological Contract Violation (PCV) in online marketplaces, a critical factor that has been largely overlooked by previous research. Applied to buyer-seller relationships, PCV is defined as a buyer’s perception of having being treated wrongly regarding the terms of an exchange agreement with an individual seller. PCV with individual sellers is proposed as a formative first-order construct driven by the occurrence of fraud, product misrepresentation, contract default, delivery delay, and failure to follow product guarantees and payment policies. PCV with an individual seller is proposed to prompt a generalized perception of PCV with the entire community of sellers in a marketplace. PCV with the community of sellers is hypothesized to negatively affect buyer transaction behavior in a marketplace by directly impacting transaction intentions, price premiums, trust, perceived risk, and the perceived effectiveness of institutional structures. PCV is also hypothesized to act as a moderator, transforming the buyers’ initial trust-based mindset to one more centered on perceived risk. Finally, PCV is hypothesized to attenuate the positive impact of trust on transaction intentions, while reinforcing the negative impact of perceived risk on transaction intentions. It is also proposed to attenuate the impact of the perceived effectiveness of institutional structures on trust, while strengthening its negative effect on perceived risk. As a means of preventing PCV, the buyers’ positive experience and the sellers’ favorable past performance are hypothesized to make PCV with the community of sellers less likely. A combination of primary and secondary longitudinal data from 404 buyers in eBay’s and Amazon’s online auctions support the proposed hypotheses, validating PCV as a central element of buyer-seller relationships in online marketplaces. Interestingly, ex post facto results show that buyers with higher perceptions of PCV with the community of sellers are less likely to experience PCV with an individual seller in the future. Implications for buyer-seller relationships in online marketplaces and the PCV literature are discussed. Also discussed is how the increasing number of buyers who experience PCV in online marketplaces extends the literature that has been largely developed based on buyers who had not experienced PCV.
High-Resolution Near-Infrared Imaging of DNA Microarrays with Time-Resolved Acquisition of Fluorescence Lifetimes (2000)

Ultrasensitive, near-infrared (NIR), time-resolved fluorescence is evaluated as a detection method for reading DNA hybridization events on solid surfaces for microarray applications. In addition, the potential of mulitiplexed analyses using time-resolved identification protocols is described. To carry out this work, a NIR time-resolved confocal imager was constructed to read fluorescence signatures from the arrays. The device utilized a 780-nm pulsed diode laser, a single-photon avalanche diode (SPAD), and a high-numerical-aperture microscope objective mounted in an epi-illumination format. Due to the small size of the components that are required to construct this imager, the entire detector could easily be mounted on high-resolution translational stages and scanned over the stationary arrays. The instrument response function of the device was determined to be 275 ps (fwhm), which is adequate for measuring fluorophores with subnanosecond lifetimes. To characterize the system, NIR dyes were deposited directly on different substrate materials typically used for DNA microarrays, and the fluorescence lifetimes of two representative dyes were measured. The fluorescence lifetime for aluminum tetrasulfonated naphthalocyanine was found to be 1.92 ns, and a value of 1.21 ns was determined for the tricarbocyanine dye, IRD800, when it was deposited onto poly(methyl methacrylate) (PMMA) and measured in the dry state. Finally, the imager was used to monitor hybridization events using probe oligonucleotides chemically tethered to a PMMA substrate via a glutardialdehyde linkage to an aminated-PMMA surface. The limit of detection for oligonucleotides containing a NIR fluorescent reporter was determined to be 0.38 molecules/microm2, with this detection limit improving by a factor of 10 when a time-gate was implemented. Fluorescence lifetime analysis of the hybridization events on PMMA indicated a lifetime value of 1.23 ns for the NIR-labeled oligonucleotides when using maximum-likelihood estimators.
High‐power in‐phase coherently coupled VCSEL array based on proton implantation (2014)

Three‐element in‐phase coherently coupled arrays of vertical cavity surface‐emitting lasers (VCSELs) were fabricated using proton implantation. The arrays show excellent beam quality with a far‐field divergence of 4°, while maintaining a stable in‐phase mode until a maximum output power of 4 mW under continuous‐wave condition. The process for the arrays is simple and the cost is low.
Design and implementation of a trader-based resource management system (1994)

Distributed computing systems are composed of various types and sizes of resources. Providing a reliable and efficient distributed computing environment largely depends on the effective management of these resources. ISO has begun work on a proposed standard for Open Distributed Processing (ODP).The ODP framework includes a mechanism called the Trader which provides a framework for exchanging services in an open distributed computing environment. This paper presents a design of Trader-Based Resource Management System (TBRMS) which employs and extends the ODP Trader concept to the management of general resources in distributed computing systems. We describe its architecture, information model, and user interface. We also present an implementation effort of its prototype which uses the X.500 Directory Service as its resource information repository. 1 Introduction The trend of computing in the 90&apos;s is towards distributed computing. Computing systems, which are geographically dispersed, a...
Switching of a Double-Comb Microactuator by Time-Lag Modulation and Electrical-Damping Control (2000)

Abstract A switching and control scheme for a novel double-comb microactuator is proposed in this paper. The device is actuated by a time-lag modulation voltage and its transient behavior is controlled by the time lag and a resistor. Numerical simulation is applied to analyze the nonlinear transient dynamics of an example system. A transient optimization to reduce the settling time and overshoot of the time response to a time-lag modulation is carried out using the OCS performance index. The optimal control parameters are obtained including the optimal resistance and time lag to balance the performance tradeoff.
WebVR based Interactive Visualization of Open Health Data (2018)

Visualization and manipulation of complex and multivariate data in virtual worlds is important for both holders of these data and for their users. Indeed, Virtual Reality helps to make multidimensional data more intelligible and to bring useful information and knowledge. Offering Virtual Reality to browsers, also known as Web Virtual Reality, moreover, simplifies access, multi sharing and manipulation of complex and multivariate data. In this paper, we propose a new system for exploring and visualizing multidimensional data in WebVR. The system implements three methods that we compare based upon several criteria. As the area of application, we use health data that we collect from open data portals.
The First Carbonate Field Application of a New Organically Crosslinked Water Shutoff Polymer System (1999)

Abstract This paper describes the chemistry and treatment design of the first field application of a recently developed, organically crosslinked polymer (OCP) system for water shutoff. The candidate for which this treatment was designed is a production well in the North Sea that was completed in naturally fractured chalk. Each of the completed intervals were acid fractured to further open the existing natural fractures and increase production. The recommended treatment volume calculations took into account the leak-off considerations and the acid fracture volume. The method by which the leak-off requirements were calculated is described. The placement and shut-in temperatures of the recommended treatment volume were then calculated as a function of time. These simulations used a production - operation wellbore simulator in combination with an advanced processes reservoir simulator. The fractures in the target zone were defined in the grid-block system that was used in these temperature simulations. The results of these temperature calculations were used to formulate the chemical compositions of the stages of the OCP treatment and to calculate gel times and shut-in times. The calculations of these gel times and how they correspond to the gel times during the actual treatment are also described.
Memory/logic interconnect flexibility in FPGAs with large embedded memory arrays (2002)

As the capacities of field-programmable gate arrays (FPGAs) grow, it becomes desirable to create FPGAs with embedded memory arrays. This paper examines the flexibility of the interconnect structure that joins memory and logic. For architectures with only a few memory arrays, we find that both the routability and the delay of circuits are insensitive to the memory/logic interconnect flexibility, which implies that this interconnection can be made very inflexible. This is in contrast to the logic connection block flexibility, which has been shown to require high flexibility. For architectures with more arrays, the memory/logic interconnect flexibility requirements increase and approach those of logic interconnect.
The quality of care (1998)

Being able to monitor the quality of care and make continuous improvements is a fundamental part of a nurse's role, particularly for those in supervisory or managerial roles. June Girvin continues her series for nurses new to management with a look at the issues around quality
A multicriteria route planning approach considering driver preferences (2012)

Route finding is one of the primary functions of a car navigation device. Usually, one of the criterion i.e. the minimum traveling time, distance or safety etc. is selected to find the optimal route. Instead of this, a multi-criteria route planner that considers driver preferences at the same time would be more preferable. In this study, a route planning strategy that considers road safety and travel time as user selected criteria is applied. Normal pairwise comparison method and regular increasing monotone quantifier-guided ordered weighted averaging operators are used for integrating the driver preferences (e.g. relative importance and decision strategy) to form a cost for each link of a network. The proposed approach is tested for a specific region of Odunpazari district near Eskisehir Osmangazi University (ESOGU) in Eskisehir. Travel time costs of links are calculated considering the lengths and speed limits in the region. Safety costs of links are determined considering a set of parameters such as road width, number of lanes in the road, road slope, road surface type and weather conditions.
La vuelta de la melancolía. La melancolía vuelta. (1993)

Sin resumen
A Novel Inter-FA Handover Scheme for Load Balancing in IEEE 802.16e System (2007)

As the demand for high data rate increases, load balancing across cell is highly desirable. A handover (HO) among frequency assignment (FA) may be possible for load balancing theoretically, when a serving FA is crowded to accommodate additional bandwidth request in such system as IEEE 802.16e, where the multiple FAs are possible. However, this handover is impossible in the current specification because an indication to target FA is not defined. It also requires unnecessary long scanning and network re-entry procedure. In this paper, we propose novel inter-FA handover, handover among FAs for load balancing by modifying general handover algorithm. It also satisfies HO user's quality of service (QoS) by reducing HO latency, unnecessary scanning, and network re-entry. We compare with previous HO schemes for load balancing by simulation. We show that this HO scheme can achieve significantly better performance in HO user's QoS and HO delay.
Heat‐stable antigen is expressed by murine keratinocytes and delivers costimulatory signals in T‐cell activation (1995)

Heat-stable antigen (HSA), expressed by various antigen-presenting cells (APC), has been described as a costimulatory molecule for CD4+ T cells. Recently, we observed that HSA also serves as an important costimulatory molecule on epidermal Langerhans cells (LC). During these studies, low levels of HSA staining were also detected on normal murine keratinocytes (KC). To investigate whether HSA also is involved in T-cell activation by KC, normal murine KC or the spontaneously transformed KC cell-line PAM 212 were treated with PDB or PMA to induce HSA-expression. FACS analyses showed induction of HSA expression on normal murine KC, as well as PAM 212 cells. In functional assays PDB or PMA-treated normal or transformed KC were far more potent inducers of primary allogeneic T-cell responses than untreated KC. Addition of anti-HSA-specific mAb 20C9 specifically inhibited the costimulatory activity of KC, an effect that was even more pronounced when CTLA-4Ig was added to the cultures. Cleavage of HSA on KC surfaces by a phosphoinositol-specific phospholipase C (PI-PLC) also significantly inhibited the costimulatory capacity of KC for naive CD4+ T cells. In aggregate, our data indicate that expression of HSA on activated KC contributes to the capacity of these cells to induce proliferation of allogeneic T cells.