gebhart/patrepeval huggingface dataset:
Printed Circuit Board Design Techniques for EMC Compliance: A Handbook for Designers (2000)

"Electromagnetic compatibility (EMC) is an engineering discipline often identified as "black magic." This belief exists because the fundamental mechanisms on how radio frequency (RF) energy is developed within a printed circuit board (PCB) is not well understood by practicing engineers. Rigorous mathematical analysis is not required to design a PCB. Using basic EMC theory and converting complex concepts into simple analogies helps engineers understand the mitigation process that deters EMC events from occurring. This user-friendly reference covers a broad spectrum of information never before published, and is as fluid and comprehensive as the first edition. The simplified approach to PCB design and layout is based on real-life experience, training, and knowledge. Printed Circuit Board Techniques for EMC Compliance, Second Edition will help prevent the emission or reception of unwanted RF energy generated by components and interconnects, thus achieving acceptable levels of EMC for electrical equipment. It prepares one for complying with stringent domestic and international regulatory requirements. Also, it teaches how to solve complex problems with a minimal amount of theory and math. Essential topics discussed include: * Introduction to EMC * Interconnects and I/O * PCB basics * Electrostatic discharge protection * Bypassing and decoupling * Backplanes-Ribbon Cables-Daughter Cards * Clock Circuits-Trace Routing-Terminations * Miscellaneous design techniques This rules-driven book-formatted for quick access and cross-reference-is ideal for electrical and EMC engineers, consultants, technicians, and PCB designers regardless of experience or educational background." Sponsored by: IEEE Electromagnetic Compatibility Society
Photochemically Catalyzed Generation of Site-Specific 8-Nitroguanine Adducts in DNA by the Reaction of Long-Lived Neutral Guanine Radicals with Nitrogen Dioxide (2002)

A novel photochemical approach is described for synthesizing site-specific 8-nitro-2'-deoxyguanosine (8-nitro-dG) adducts DNA. The method is based on the bimolecular reaction of a neutral, deprotonated guanine radical [G(-H)*] in DNA and nitrogen dioxide (*NO(2)) radicals. This approach is illustrated using the single-stranded oligodeoxyribonucleotide 5'-d(CCATCGCTACC) dissolved in an aqueous solution of nitrite and bicarbonate anions at pH 7.5. The photochemical synthesis was triggered by the selective photodissociation of persulfate anions to yield SO(4)(*-) radical anions by either 308 nm XeCl excimer laser pulses or by a continuous irradiation with 290-340 nm light from a 1000 W Xe lamp. The sulfate radicals formed generate the CO(3)(*-) and *NO(2) radicals by one-electron oxidation of the bicarbonate and nitrite anions. In turn, the CO(3)(*-) radicals site-selectively generate G(-H)* radicals in DNA that combine with *NO(2) to form 8-nitro-dG lesions in the oligonucleotide. The nitrated oligonucleotides were purified by reversed-phase HPLC techniques and are stable at 4 degrees C for at least 4 days, but depurinate at ambient temperatures of 23 degrees C at pH 7 with a half-life of approximately 20 h. The nature of the reaction and decomposition products were studied by a combination of ESI and MALDI-TOF mass spectrometric techniques.
Constraint validation support in visual model transformation systems (2005)

Model-Driven Architecture (MDA) standardized by OMG facilitates to separate the platform independent part and the platform specific part of a system model. Due to this separation Platform-Independent Model (PIM) can be reused across several implementation platforms of the system. Platform-Specific Model (PSM) is ideally generated automatically from PIM via model transformation steps. Because of the appearance of high level languages, object-oriented technologies and CASE tools, metamodeling becomes more and more important. Metamodeling is one of the most central techniques both in design of visual languages, and reuse existing domains by extending the metamodel level. The creation of model compliers on a metamodeling basis is illustrated by a software package called Visual Modeling and Transformation System (VMTS), which is an n-layer multipurpose modeling and metamodel-based transformation system. VMTS is able to realize an MDA model compiler. This paper (i) addresses the relationship between the constraints enlisted in metamodel-based rewriting rules and the pre-and postconditions, (ii) it introduces the concepts of general validation, general preservation and general guarantee, which facilitate that if a transformation step is specified adequately with the help of constraints, and the step has been executed successfully for the input model, then the generated output model is in accordance with the expected result, which is described by the transformation step refined with the constraints.An illustrative case study based on constraint specification in rewriting rules is also provided.
Modification of ventricular fibrillation latency following coronary artery occlusion in the conscious pig. (1975)

Abrupt occlusion of the left anterior descending coronary artery was performed on 45 unanesthetized farm pigs in order to evaluate the relative effects on the latency to ventricular fibrillation (VFL) of 1) adaptation of the animals to the laboratory, and 2) beta-receptor blockade by propranolol. Compared to control values, VFL was greatly lengthened (i.e., VF delayed or prevented) by adaptation (P smaller than 0.01), was shortened by large (2 MG/KG) doses of racemic propranolol in unadapted animals (P smaller than 0.02), and was again increased while under the influence of the drug, by adaptation (P smaller than 0.051). Neither a lower (0.02 mg/kg) dose of racemic propranolol, 2 mg/kg of dextropropranolol, nor ventricular pacing to a higher heart rate had an effect on VFL. The results suggest that reduced psychological stress was very effective in retarding or preventing the onset of VF, that low doses of propranolol were ineffective, and that higher doses were deleterious in unadapted animals.
Toll Receptors (2002)

This has led to the identification of several important roles for Toll receptors in mammals. This unit discusses mammalian Toll receptors (TLR1-10) that have an essential role in the innate immune recognition of microorganisms. Also discussed are TLR-mediated signaling pathways and antibodies that are available to detect specific TLRs.
An MLSE receiver for electronic-dispersion compensation of OC-192 fiber links (2006)

A 9.953 to 12.5Gb/s MLSE receiver consisting of an AFE IC in a 0.18μ m 3.3V f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">t</sub> =75GHz, and a digital IC in a 0.13pm 1.2V CMOS is presented. The AFE IC features a 7.5GHz 40dB VGA, a 4b 12.5GS/S ADC, a dispersion-tolerant clock-recovery unit, and a 1:8 DEMUX. The digital IC implements an 8-parallel, delayed recursion MLSE architecture and a nonlinear channel estimator. The 4.5W receiver meets the SONET jitter specifications with 2200ps/nm of dispersion at BER=10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sup>
Multiport wavelength routers using multimode interference (1997)

We propose a dynamic wavelength router using a multimode interference coupler and Bragg gratings implementing multiport wavelength switching in a single device together with a new wavelength dilation method using this device. We show a design of the new dynamic wavelength router and device performance using eigenmode decomposition. The flat passband and low crosstalk characteristics are attained.
A Radio Spectrum Measurement System for Frequency Management Data (1977)

Since 1973, the U. S. Office of Telecommunications has been operating a Radio Spectrum Measurement System (RSMS) for the Office of Telecommunications Policy (OTP) in support of federal frequency management processes. The RSMS is a van-deployed computer-controlled receiving system designed to make many different types of measurements between 100 MHz and 12 GHz. The RSMS has been used in measurement programs on selected Federal Government communication and radar bands in many high spectrum usage areas in the Unites States. This paper discusses the capabilities of the RSMS van, and uses some measured data as examples of those capabilities.
<b>Characterisation of the ethanol‐inducible</b><i><b>alc</b></i><b>gene expression system for transgenic plants</b> (1998)

Summary We describe a chemically induced gene control mechanism for plants based on the ALCR transcription factor and alcA promoter of Aspergillus nidulans , which we have called the alc system. Ethanol, the chemical inducer, is not toxic at levels required for induction, and can be applied to the plants by spraying, root drenching and addition to liquid growth media. The alc system is very sensitive to ethanol and the induction is rapid; 0.01% (1.7 mM) ethanol in liquid growth media initiates chloramphenicol acetyl transferase (CAT) reporter gene expression within 4 h, with maximal expression occurring after 4 days. In the complete absence of ethanol, there is no detectable expression of CAT, nor do we observe induction in plants subjected to wound, cold or drought stress, or following treatment with either salicylic acid or methyl jasmonate. However, extreme anoxia resulting in elevated levels of alcohol dehydrogenase activity in both roots and leaves gave substantial induction of CAT in leaves but not in roots. We believe that the alc system will have broad utility in the exogenous control of plant gene expression in pure science and that it also has considerable potential in agriculture.
High-efficiency and low-efficiency-roll-off single-layer white organic light-emitting devices with a bipolar transport host (2012)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Yongming Yin, Xuecheng Piao, Yang Li, Yan Wang, Jian Liu, Kai Xu, Wenfa Xie; High-efficiency and low-efficiency-roll-off single-layer white organic light-emitting devices with a bipolar transport host. Appl. Phys. Lett. 6 August 2012; 101 (6): 063306. https://doi.org/10.1063/1.4745507 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioApplied Physics Letters Search Advanced Search |Citation Search
Event‐related Brain Potentials in Individuals at High and Low Risk for Developing Alcoholism: Failure to Replicate (1988)

Event-related brain potentials (ERPs) were used to compare young men having a positive paternal family history for alcoholism (FHP) with carefully matched control subjects having no family history for alcoholism (FHN). The P300 ERP component was obtained from all subjects (n = 10/group) with a complex auditory paradigm before and on two occasions after they received a placebo drink which they were told might contain alcohol. The procedures employed replicated those of a previous study in which FHP subjects showed diminished P300 potentials compared to FHN subjects under the placebo as well as ethanol consumption conditions--a finding which raised the possibility that the P300 ERP component might be a biological marker for subjects at high risk to develop alcoholism. No differences between the family history groups were obtained for the P300 or any other ERP component using the replication procedures. Both groups demonstrated a decrease in P300 amplitude across trial blocks in a similar fashion suggesting that habituation effects may have diminished the ERP response.
Synthetic-Bioinformatic Natural Product Antibiotics with Diverse Modes of Action (2020)

Bacterial natural products have inspired the development of numerous antibiotics in use today. As resistance to existing antibiotics has become more prevalent, new antibiotic lead structures and activities are desperately needed. An increasing number of natural product biosynthetic gene clusters, to which no known molecules can be assigned, are found in genome and metagenome sequencing data. Here we access structural information encoded in this underexploited resource using a synthetic-bioinformatic natural product (syn-BNP) approach, which relies on bioinformatic algorithms followed by chemical synthesis to predict and then produce small molecules inspired by biosynthetic gene clusters. In total, 157 syn-BNP cyclic peptides inspired by 96 nonribosomal peptide synthetase gene clusters were synthesized and screened for antibacterial activity. This yielded nine antibiotics with activities against ESKAPE pathogens as well as <i>Mycobacterium tuberculosis</i>. Not only are antibiotic-resistant pathogens susceptible to many of these syn-BNP antibiotics, but they were also unable to develop resistance to these antibiotics in laboratory experiments. Characterized modes of action for these antibiotics include cell lysis, membrane depolarization, inhibition of cell wall biosynthesis, and ClpP protease dysregulation. Increasingly refined syn-BNP-based explorations of biosynthetic gene clusters should allow for more rapid identification of evolutionarily inspired bioactive small molecules, in particular antibiotics with diverse mechanism of actions that could help confront the imminent crisis of antimicrobial resistance.
Fade to Black: The Formalization of Jackson's Youngstown Taxonomy by Hamdan and Medellin (2009)

This Comment argues that the Court’s holding in Medellin modifies Jackson’s tripartite taxonomy by effectively eliminating the “zone of twilight.” By requiring a “systematic, unbroken, executive practice, long pursued to the knowledge of the Congress and never before questioned,” the Court is essentially extending the first category—executive action with the express or implied authorization of Congress—to cover the middle “zone of twilight,” at odds with the very purpose of the zone. Additionally, the Comment argues that Hamdan establishes Congress’s “disabling” power in the third category, which, combined with Medellin’s interpretation, crates a new standard for Jackson’s taxonomy, one moor similar to Justice Black’s formalist majority opinion in Youngstown than Justice Jackson’s functionalist concurring opinion.\nPart II will give a background to Jackson’s concurrence in Youngstown, and the effect that his tripartite taxonomy has had on separation of powers issues, particularly focusing on the Court’s adoption and interpretation of the taxonomy in Dames &amp; Moore v. Regan. Part III will analyze the Court’s treatment of the taxonomy in Hamdan and Medellin and argue that the two cases create a new standard, one that extends the first category to include a longstanding history of congressional acquiescence , eliminates the “zone of twilight,” and forecloses executive action in the third category. Part IV analyzes potential ramifications of this new standard on the executive’s foreign affairs and war powers, and Part V concludes by calling for the Supreme Court to clarify whether the new standard established by Hamdan and Medellin was intentional or inadvertent.
Algorithms for management of a multi-platooning system of IVC-enabled autonomous vehicles, with high traffic capacity (2011)

Intra-platoon positioning management strategies to deal with safe and efficient advanced traffic management system operation are proposed in this paper. New algorithms to ensure high traffic capacity are proposed, and Matlab/Simulink-based simulation results are reported. Recently, we proposed new algorithms to mitigate communication delays using anticipatory information, both from the platoon's leader and the followers, with significant impact on the improvement of platoon string stability [5]. In this paper, we argue that maintaining a constant spacing between platoons' leaders has a positive impact on the traffic capacity of the whole system. As such, when the leader and eventually other vehicles immediately behind it leave the platoon, the new leader must accelerate to reach the position of the previous leader, to ensure inter-leader constant spacing and, consequently, enough spacing to be eventually occupied by new followers. We developed a novel architecture where each vehicle consists of two distinct modules: a leader and a follower. Based on Matlab/Simulink-based simulation, the new algorithms are assessed, and simulation results presented. The obtained simulation results confirm that the proposed algorithms adapt the acceleration pattern, ensuring similar timings for all possible cases of the previous position of new leaders in the platoon, when performing their repositioning maneuvers.
LRH-1 drives colon cancer cell growth by repressing the expression of the<i>CDKN1A</i>gene in a p53-dependent manner (2015)

Liver receptor homologue 1 (LRH-1) is an orphan nuclear receptor that has been implicated in the progression of breast, pancreatic and colorectal cancer (CRC). To determine mechanisms underlying growth promotion by LRH-1 in CRC, we undertook global expression profiling following siRNA-mediated LRH-1 knockdown in HCT116 cells, which require LRH-1 for growth and in HT29 cells, in which LRH-1 does not regulate growth. Interestingly, expression of the cell cycle inhibitor p21 (CDKN1A) was regulated by LRH-1 in HCT116 cells. p21 regulation was not observed in HT29 cells, where p53 is mutated. p53 dependence for the regulation of p21 by LRH-1 was confirmed by p53 knockdown with siRNA, while LRH-1-regulation of p21 was not evident in HCT116 cells where p53 had been deleted. We demonstrate that LRH-1-mediated p21 regulation in HCT116 cells does not involve altered p53 protein or phosphorylation, and we show that LRH-1 inhibits p53 recruitment to the p21 promoter, likely through a mechanism involving chromatin remodelling. Our study suggests an important role for LRH-1 in the growth of CRC cells that retain wild-type p53.
Combining Radiation Therapy and Androgen Deprivation for Localized Prostate Cancer—A Critical Review (2010)

Interest has been increasing in the use of androgen deprivation therapy (ADT) combined with radiation therapy (RT) in the management of localized prostate cancer. Preclinical studies have provided some rationale for the use of this combination. In patients with high-risk disease, the benefit of a combined approach, with the addition of adjuvant hormonal therapy, is supported by results of randomized trials. In contrast, for patients with low-risk disease, there is no obvious therapeutic advantage except for cytoreduction. The usefulness of short-term hormonal therapy in association with rt for intermediate-risk patients is still debatable, particularly in the context of doseescalated RT. The optimal timing and duration of ADT, in the neoadjuvant and adjuvant settings alike, are still under investigation. In view of the potential side effects with ADT, further studies are being performed to better identify subsets of patients who will definitely benefit from this therapy in combination with rt.
Spatial reconstruction of marker trajectories from high-speed video image sequences (1997)

A novel method is presented for the spatial reconstruction of marker trajectories, which describe the motion of articulating segments of the human or animal body or of a technical construction. In human motion analysis, such markers may be attached to landmark points defining the configuration of the subject. A high-speed video-recording system comprising two cameras is used for motion data acquisition. The particular images are composed of the synchronous recordings of both cameras; the resolution of one image is 239 x 192 pixels, which is comparatively low. To obtain high precision, a new centre estimation method has been developed to calculate the image coordinates of the centres of the recorded spherical markers to subpixel precision. Image coordinates of the centres in subsequent frames are obtained by first applying a tracing algorithm, which calculates the position of a marker to pixel precision, and then using the new centre estimation method. The reconstruction of the spatial coordinates from the image coordinates is based on a three-dimensional photogrammetric calibration and results in deviations of about 0.1%. The instantaneous acceleration of a falling ball has been calculated. The average deviation from the gravitational constant was comparatively small. From the accuracy of the results, it can be concluded that the novel method is applicable in connection with the high-speed video-recording system presently used. Moreover, the techniques are suitable for reconstructing three-dimensional marker trajectories from any low-resolution video image sequences recorded simultaneous with at least two cameras.
Parameter estimation in a multi-user communication system (1994)

Many of the previously-developed multiple-access detection algorithms have assumed knowledge of the time delay, the amplitude, and the phase of each user. This paper presents methods of estimating the amplitudes and phases, both when the time delays are known and when the delays are unknown. In neither case are the transmitted bits assumed to be known. The estimators are unbiased and consistent, and each has a computational complexity linear in the number of users. Simulations are provided to demonstrate performance.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
p42 mitogen-activated protein kinase and p90 ribosomal S6 kinase are selectively phosphorylated and activated during thrombin-induced platelet activation and aggregation (1994)

Human platelets provide an excellent model system for the study of phosphorylation events during signal transduction and cell adhesion. Platelets are terminally differentiated cells that exhibit rapid phosphorylation of many proteins upon agonist-induced activation and aggregation. We have sought to identify the kinases as well as the phosphorylated substrates that participate in thrombin-induced signal transduction and platelet aggregation. In this study, we have identified two forms of mitogen-activated protein kinase (MAPK), p42mapk and p44mapk, in platelets. The data demonstrate that p42mapk but not p44mapk becomes phosphorylated on serine, threonine, and tyrosine during platelet activation. Immune complex kinase assays, gel renaturation assays, and a direct assay for MAPK activity in platelet extracts all support the conclusion that p42mapk but not p44mapk shows increased kinase activity during platelet activation. The activation of p42mapk, independently of p44mapk, in platelets is unique since in other systems, both kinases are coactivated by a variety of stimuli. We also show that platelets express p90rsk, a ribosomal S6 kinase that has previously been characterized as a substrate for MAPK. p90rsk is phosphorylated on serine in resting platelets, and this phosphorylation is enhanced upon thrombin-induced platelet activation. Immune complex kinase assays demonstrate that the activity of p90rsk is markedly increased during platelet activation. Another ribosomal S6 protein kinase, p70S6K, is expressed by platelets but shows no change in kinase activity upon platelet activation with thrombin. Finally, we show that the increased phosphorylation and activity of both p42mapk and p90rsk does not require integrin-mediated platelet aggregation. Since platelets are nonproliferative cells, the signal transduction pathways that include p42mapk and p90rsk cannot lead to a mitogenic signal and instead may regulate cytoskeletal or secretory changes during platelet activation.