gebhart/patrepeval huggingface dataset:
Aptamer-Targeted DNA Nanostructures for Therapeutic Delivery (2014)

DNA-based nanostructures have been widely used in various applications due to their structural diversity, programmability, and uniform structures. Their intrinsic biocompatibility and biodegradability further motivates the investigation of DNA-based nanostructures as delivery vehicles. Incorporating AS1411 aptamers into DNA pyramids leads to enhanced intracellular uptake and selectively inhibits the growth of cancer cells, achieved without the use of transfection reagents. Furthermore, aptamer-displaying pyramids are found to be substantially more resistant to nuclease degradation than single-stranded aptamers. These findings, along with their modularity, reinforce the potential of DNA-based nanostructures for therapeutic applications.
A phase II trial of abiraterone acetate (AA) without prednisone in castration resistant prostate cancer (CRPC). (2017)

5040 Background: AA blocks CYP17 and suppresses adrenal androgens and glucocorticoids. Given the risk of mineralocorticoid excess (ME), AA is administered with corticosteroids. In this phase II multicenter, single-arm study, we assess the safety of AA without steroids in CRPC. The primary objective is to determine the proportion of men requiring prednisone to manage ME. Methods: Eligible patients had CRPC with controlled blood pressure (BP) ( < 140/90 on ≤3 agents) and a normal or ≥3.5 mmol/L potassium. Patients initially received AA (1000 mg daily) alone. Patients who developed a BP ≥ 140/90 were treated with anti-hypertensives (HTN) and/or a mineralocorticoid antagonist (MA) prior to steroids. Hypokalemia was treated with supplementation or a MA. Patients with persistent or severe ME were initiated on prednisone (5 mg twice daily). To assess response to steroids, prednisone was added to AA at PSA progression. Therapy was continued until radiographic progression, toxicity, or withdrawal. Results: 60 patients were enrolled of whom 51 (83%) had metastases 16 (27%) received prior chemotherapy, 6 (10%) enzalutamide, and 4 (7%) ketoconazole. Grade (G) 3-4 adverse events (AEs) of interest included HTN (G3 n = 8, 13%; G4 n = 1, 2%), hypokalemia (G3 n = 4, 7%; G4 n = 0), fatigue (G3 n = 1, 2%; G4 n = 0). There was no G ≥3 edema. 9 patients (15%) initiated prednisone for toxicity: HTN (n = 3, 5%), hypokalemia (n = 4, 7%), fatigue (n = 2, 3%). Baseline PSA was 15.4 ng/mL. Time to nadir PSA was 2.5 months (IQR 1.4, 6.3) and median nadir PSA was 2.1 ng/mL. 67% of patients (n = 40) experienced a ≥50% PSA decline and 35% (n = 21) experienced a ≥90% decline. 19 patients (32%) initiated prednisone for PSA progression. Median time to prednisone initiation in patients with PSA progression was 6.1 months (IQR 4.9, 11.7); 5 patients (8.3%) had a PSA decline and 1 achieved a ≥50% decline. Levels of corticosteroids will be reported. Conclusions: In CRPC, AA without steroids is feasible, however clinically significant AEs, particularly HTN, can occur in a minority of patients. HTN and hypokalemia can be treated with anti-HTN agents or potassium without steroids in the majority. Use of AA without prednisone needs to be balanced with the potential risk of toxicity. Clinical trial information: NCT02025010.
O'Nyong-Nyong fever: An epidemic virus disease in East Africa (1965)

Journal Article O'Nyong-Nyong fever: An epidemic virus disease in East Africa Get access M.C. Williams, M.C. Williams East African Virus Research Institute, Entebbe, Uganda Search for other works by this author on: Oxford Academic PubMed Google Scholar J.P. Woodall, J.P. Woodall East African Virus Research Institute, Entebbe, Uganda Search for other works by this author on: Oxford Academic PubMed Google Scholar J.D. Gillett J.D. Gillett Department of Biology, Brunel College, London, W.3. UK Search for other works by this author on: Oxford Academic PubMed Google Scholar Transactions of The Royal Society of Tropical Medicine and Hygiene, Volume 59, Issue 2, March 1965, Pages 186–197, https://doi.org/10.1016/0035-9203(65)90080-5 Published: 01 March 1965
The influence of dissolved gas on the interactions between surfaces of different hydrophobicity in aqueous media Part II. A spectroscopic study (1999)

The aggregation of smooth hydrophobic and hydrophilic silica particles in the presence of different gases has been investigated at pH 5.6 and 10-4 M KNO3, using the attenuated total internal reflectance Fourier transform infrared spectroscopy (ATR-FTIR) technique. The rate of aggregation of methylated silica is enhanced in the presence of dissolved CO2 but is unaffected by dissolved air, argon or nitrogen. The aggregation of hydrophilic and heat treated dehydroxylated silica is not influenced by any gas tested. For methylated silica, CO2 adsorbs on to the surface as tiny microbubbles. These microbubbles decrease the colloid stability of the methylated silica particles, overcoming the electrostatic repulsion at pH 5.6 and 10-4 M KNO3. The results obtained are in broad agreement with our previous atomic force microscopy (AFM) investigation of interparticle forces and bubble–particle heterocoagulation studies.
An accurate system for automated on-wafer characterization of three-port devices (2002)

A general-purpose system for fast, automated acquisition of the S-parameters of three-port components is described, which is suitable for accurate device characterization as well as RF testing of three-port circuits in a production environment. Though based on conventional, nonrepeatable, electromechanical switches, the system achieves state of the art accuracy for on-wafer measurements by means of suitable hardware design and the application of time-domain gating. The system is applied to the characterization of MMIC (monolithic microwave IC) T-coils and single-pole double-throw (SPDT) switches. The bandwidth is now limited to 20 GHz but can be easily upgraded to 26.5 GHz by replacing one of the switches. Acquisition of the corrected S-parameters takes about 15 seconds (51 frequency points) with a HP 9000/330 controller.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Continuous-flow immunosensor for detection of explosives (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTContinuous-flow immunosensor for detection of explosivesJames P. Whelan, Anne W. Kusterbeck, Gregory A. Wemhoff, Reinhard. Bredehorst, and Frances S. LiglerCite this: Anal. Chem. 1993, 65, 24, 3561–3565Publication Date (Print):December 15, 1993Publication History Published online1 May 2002Published inissue 15 December 1993https://pubs.acs.org/doi/10.1021/ac00072a005https://doi.org/10.1021/ac00072a005research-articleACS PublicationsRequest reuse permissionsArticle Views413Altmetric-Citations96LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Mapping epitopes to distinct regions of the extracellular domain of endoglin using bacterially expressed recombinant fragments (1997)

Endoglin (CD105) is a homodimeric cell surface component of the TGF-beta 1 receptor complex, which is expressed at high levels on vascular endothelium and at lower levels on activated monocytes. It is also the target gene for the dominantly inherited vascular disorder hereditary hemorrhagic telangiectasia type 1. To date, each family has a distinct endoglin mutation, most of which generate premature stop codons. The purpose of the current study was to identify monoclonal antibodies capable of binding to normal and mutated forms of the protein. We generated stable transfectants of full-length human endoglin in murine fibroblasts and engineered and expressed in bacteria several fragments of the extracellular domain. Relatively pure polypeptides were recovered with good yield from inclusion bodies and were tested by ELISA and Western blot; 11 monoclonal antibodies were shown to react specifically with the endoglin transfectants. Ten of these monoclonal antibodies reacted with the bacterial fragments, and their epitopes were assigned to 3 distinct regions of endoglin. Monoclonal antibodies P3D1, TEC4 and GRE reacted with the N-terminal region of 204 amino acids encoded by exons 1 to 5. Monoclonal antibodies P4A4, 44G4, E-9, MAEND3 and PN-E2 all bound to a region of 54 amino acids encoded mostly by exon 7. Monoclonal antibodies CLE4 and RMAC8 reacted with the C-terminal region of the extracellular domain, coded for by exons 8 to 12. Knowing the localization of these epitopes will facilitate the structural and functional analysis of normal and mutated forms of endoglin.
Projective Mappings for Image Warping (1995)

.56&gt; 6=0form the equivalence class of homogeneous representations for the real point #x; y# T . To recover the actual coordinates from a homogeneous vector, we simply divide by the homogeneous component; e.g., the homogeneous vector p =#xw;yw;w# T =#x 0 ;y 0 ;w# T represents the actual point #x; y# T =#x 0 =w;y 0 =w# T . This division, a projection onto the w =1plane, cancels the effect of scalar multiplication by w. When representing real points with homogeneous notation we could use any nonzero w, but it is usually most convenient to choose w =1so that the real coordinates can be recovered without division. Projective space also includes the
Reconstruction of Personalized 3D Face Rigs from Monocular Video (2016)

We present a novel approach for the automatic creation of a personalized high-quality 3D face rig of an actor from just monocular video data (e.g., vintage movies). Our rig is based on three distinct layers that allow us to model the actor’s facial shape as well as capture his person-specific expression characteristics at high fidelity, ranging from coarse-scale geometry to fine-scale static and transient detail on the scale of folds and wrinkles. At the heart of our approach is a parametric shape prior that encodes the plausible subspace of facial identity and expression variations. Based on this prior, a coarse-scale reconstruction is obtained by means of a novel variational fitting approach. We represent person-specific idiosyncrasies, which cannot be represented in the restricted shape and expression space, by learning a set of medium-scale corrective shapes. Fine-scale skin detail, such as wrinkles, are captured from video via shading-based refinement, and a generative detail formation model is learned. Both the medium- and fine-scale detail layers are coupled with the parametric prior by means of a novel sparse linear regression formulation. Once reconstructed, all layers of the face rig can be conveniently controlled by a low number of blendshape expression parameters, as widely used by animation artists. We show captured face rigs and their motions for several actors filmed in different monocular video formats, including legacy footage from YouTube, and demonstrate how they can be used for 3D animation and 2D video editing. Finally, we evaluate our approach qualitatively and quantitatively and compare to related state-of-the-art methods.
Dentin Matrix Protein 1 Is Expressed in Human Lung Cancer (2003)

In this study, we show that a third SIBLING protein is ectopically expressed in lung cancer. The role of DMP1 in lung cancer is largely unknown. Further studies are required to determine the implication of this protein, next to its sisters SIBLING proteins, in tumor progression and bone metastasis development.
Effects of Ventilator Resistance and Compliance on Phrenic Nerve Activity in Spontaneously Breathing Cats (1996)

This study investigates the effects of respiratory mechanical loading and unloading on phrenic nerve activity and ventilation. Ten adult cats were anesthetized, intubated, and connected to a servocontrolled infant ventilator while breathing spontaneously in continuous positive airway pressure mode. The ventilator was then set to decrease the pressure at the airway opening in proportion to the inspiratory airflow or the volume of spontaneous breathing (resistive or elastic loading) or to increase the pressure at the airway opening accordingly (resistive or elastic unloading, also called proportional assist ventilation). When compared with continuous positive airway pressure, both resistive and elastic loading increased the number of phrenic nerve impulses per breath and the mean frequency of impulses (p < 0.01, ANOVA). In contrast, elastic unloading decreased phrenic nerve activity significantly in normal and injured lungs. Resistive unloading in normal lungs did not change phrenic nerve activity significantly. The compensatory response in phrenic nerve activity was not large enough to completely offset effects of loading and unloading on ventilation: elastic and resistive loading decreased ventilation. Unloading had the opposite effect on ventilation, particularly in injured lungs. We conclude that respiratory mechanical loading and unloading have statistically significant, opposite effects on phrenic nerve activity and opposite effects on ventilation.
Novel amine-catalysed hydroalkoxylation reactions of activated alkenes and alkynes (2004)

Substoichiometric loadings of DBU catalyse the efficient 1,4-addition of alcohols and non-nucleophilic amines such as pyrrole to activated alkenes; the application of this methodology in a one-pot synthesis of a natural product, and as a novel strategy for the synthesis of mono-protected 1,3-carbonyl compounds is reported.
Economic reform and unemployment in Vietnam (2005)

Economic growth in Vietnam has been remarkable over the past two decades due
to the economic reform strategy (Doi moi), which started in the mid-1980s. In early
1990s, annual gross domestic product (GDP) growth averaged 7.4 per cent, more
than double the rate of the previous decade (Zhu 2002). The Asian Crisis reduced
this ﬁgure to 4.8 per cent in 1999 but growth has risen during the last few years,
reaching 7.2 per cent in 2003 (see Table 10.1) (UNDP 2004). Since 2000, Vietnam’s
GDP growth has been the second fastest in the East Asian region after China
(Saigon Times Magazine 2004; Xuan Trung 2004).
Synthetic Ultra-Wideband Integrated Pulse Generator for Millimeter-Wave Imaging Applications (2020)

This work presents three integrated pulse generators that can collectively provide a synthetic ultra-wide imaging bandwidth of 100 GHz in the millimeter-wave regime. Such a development is the first step towards the realization of a fully-integrated ultra-high-resolution imaging chip for biomedical applications. The pulse generators are designed in a Global Foundry 130-nm SiGe BiCMOS process technology and produce pulses with frequency ranges of 10-40-GHz, 40-75-GHz, and 75-110-GHz respectively. The three sub-band pulse generators possess a similar differential pulsed VCO configuration with the highest average power consumption of 40 mW.
The role of transit peptides in the localization of chloroplastic proteins: Progress report (1989)

Sjef Smeekens in the Utrecht group had just isolated a cDNA clone for PC and plans had been made for him to bring it to our lab to conduct import studies. In that application we proposed to examine the pathway of PC transport to the thylakoid lumen and to investigate the role of the transit peptide in that process. Additionally we proposed to begin studies aimed at investigating protein transport to the chloroplastic envelope. The progress made during the last three years in achieving these objectives is outlined below. During this grant period, we initiated some additional studies aimed at investigating the effect of known topogenic sequences on targeting within chloroplasts. Our results in these studies are also presented below. The descriptions provided in this report outline the major findings and conclusions.
Experimental characterization of transmission lines in thin-film multichip modules (1996)

Signal propagation on transmission lines fabricated in thin polyimide films on silicon substrates is investigated. Series resistive and shunt conductive losses are separated and it is shown that the effective dielectric loss is much higher than that expected from bulk material properties.
Carbon fibre reinforced plastic slotted waveguide antenna (2010)

Ten-slot slotted waveguide antennas manufactured from aluminium and carbon fibre reinforced plastic were designed, manufactured and tested. The carbon fibre reinforced plastic was commercially available aerospace grade prepreg tape and metallic lining was not used in the waveguides. The antennas operated at X-band with uniform aperture distribution a uniform aperture distribution. The only difference in antenna performance was an additional 2dB ohmic loss in the carbon fibre reinforced plastic antenna, which was caused by the low conductivity of that material. Otherwise, the two antennas were fully interchangeable. This work demonstrates the feasibility of incorporating slotted waveguide antennas into structures manufactured from CFRP.
Syntheses and Reactions of 2-Substituted Thiazolidines (1972)

2-Substituted thiazolidines (IIIa-g) were prepared by the reaction of 2-alkylthiothiazolines (II) and active methylene compounds. The tetra-substituted double bonds of IIIa-g were resistant to catalytic hydrogenation. N-Halogenation of IIIb was effected by t-butylhypochlorite or bromine in methanol-chloroform. BF3-etherate treatment of IIIb in acetic anhydride gave three products, VI, VII and VIII. This new method of furoxane formation was also applicable to the conversion of ethyl nitroacetate to VI. The mechanisms of the formations of VI and VII are proposed briefly in Chart 4.
THE FLUORESCENCE OF ADENINE. THE EFFECTS OF SOLVENT AND TEMPERATURE ON THE QUANTUM YIELD (1968)

Abstract— To investigate the mechanism of the solvent and thermal quenching of fluorescence, the absolute fluorescence quantum yield of adenine has been determined in several alcoholic glasses as a function of the concentration (10 ‐5 ‐10 ‐4 M) and temperature (77°‐298°K). The yield is independent of the concentration but increases with decreasing temperature and increasing bulk cohesion and rigidity of the solvent. The environmental effects on the yield are attributed to radiationless electronic relaxation processes caused by solute‐solvent interaction. Increasing the temperature and decreasing the intra‐solvent cohesion cause increases in the interaction and therefore accelerate the relaxation. The rate determining step behaves like a diffusion in the limit of low viscosity.
ZnO: an attractive option for n-type metal-interfacial layer-semiconductor (Si, Ge, SiC) contacts (2012)

We propose ZnO as an attractive interfacial layer (IL) option for n-type metal-IL-semiconductor (MIS) contacts because of (i) good conduction band alignment between ZnO and Si/Ge/SiC, (ii) high n-type doping possible in ZnO, and, (iii) low Fermi-level pinning factor for metal/ZnO contacts. Device simulations suggest better scalability for MIS contacts versus silicides/germanides for future FinFET technologies. Contact diode measurements on Ti/n <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+</sup> -ZnO/n-Ge and Ti/n <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+</sup> -ZnO/n-Si devices show nearly 1000X increase in current densities due to the presence of an n <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+</sup> -ZnO IL. In comparison to alternate IL options such as Al <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> and TiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> , n <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+</sup> -ZnO gives significantly higher current densities on n-Ge as demonstrated through device simulations and experimental data. Specific contact resistivity of (0.8-1.5) × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-6</sup> Ω cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> is demonstrated through four-probe measurements on circular TLM devices fabricated on n <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+</sup> -Ge (1 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">19</sup> cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-3</sup> ) epi layers using n <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+</sup> -ZnO IL.
An ethyl acetate sensor utilizing cataluminescence on Y<sub>2</sub>O<sub>3</sub> nanoparticles (2009)

A cataluminescence (CTL) sensor using Y₂O₃ nanoparticles as the sensing materials was proposed for the determination of ethyl acetate. This ethyl acetate sensor showed high sensitivity and specificity at the optimal temperature of 264°C. Quantitative analysis was performed at a wavelength of 425 nm. The linear ranges of CTL intensity vs ethyl acetate concentrations were 2.0-250 ppm (r = 0.9965) and 250-6500 ppm (r = 0.9997) with a detection limit (3σ) of 0.5 ppm. There was no response or weak response when foreign substances such as formic acid, n-hexane, toluene, acetic acid, benzene, and formaldehyde passing through the surface of Y₂O₃ nanoparticles. The sensor had a long lifetime more than 80 h with 3600 ppm ethyl acetate. It had been applied successfully to determine ethyl acetate in artificial air samples.
Implementing ITIL-Based CMDB in the Organizations to Minimize or Remove Service Quality Gaps (2008)

"Gap" is a fundamental problem in every organization and there are some models and methods to "identify" and remove or minimize those gaps in the organizations . This paper tries to use an ITIL based solution to remove or abate those "key discrepancies" in the organizations based on using Model of Service Quality Gaps(S. Q. G) as a most known model to identify gaps in the organizations in perspective of service quality. In this study the following questions were answered: Which gap or gaps are in the organizations based on S.Q.G model? ; Which method is better to make such ITIL- based repository? ; And how CMDB can be used within S. Q. G model in order to remove or abate known gaps?