gebhart/patrepeval huggingface dataset:
A Three-CCD HDTV Color Camera (1990)

The development of an HDTV color camera employing three 2-million-pixel charge-coupled device (CCD) image sensors is described. One unique characteristic of this camera is its high sensitivity, achieved by imaging devices overlaid with amorphous silicon. The horizontal-CCD (H-CCD) registers are driven by a switching resonance method, which consumes only one-fourth the power required by the conventional voltage-buffer driving method. Noise suppression for I/f amplifier noise, which decreases inversely proportional to the frequency, and floating diffusion reset noise in the CCD image sensors are also described.
Blood flow in transplantable bladder tumors treated with hematoporphyrin derivative and light. (1984)

Following hematoporphyrin derivative (HPD) photochemotherapy, blood flow to transplantable N-[4-(5-nitro-2-furyl)-2-thia-zolyl] formamide-induced urothelial tumors was determined by a radioactive microsphere technique using either 103Ru or 141Ce. Two tumors were implanted s.c. on the abdominal wall of Fischer 344 weanling rats. HPD (10 mg/kg body weight) was administered 24 hr prior to phototherapy (red light, greater than 590 nm; 360 J/sq cm). One of the two tumors was shielded from light exposure and served as an internal control. Blood flows were determined in control animals that received no treatment (Group 1), HPD only (Group 2), or light only (Group 3). In Groups 4 and 5, animals received the combination of HPD and light but differed in the time interval between treatment and blood flow determinations (10 min and 24 hr, respectively). Only blood flow to tumors treated with HPD and light showed a significant decrease (p less than 0.05) when compared with their internal controls both at 10 min (Group 4) and 24 hr (Group 5) after completion of phototherapy. These studies suggest that disruption of tumor blood flow may be an important mechanism of action of this method of cancer therapy.
Efficacy and safety of duloxetine for treatment of fibromyalgia in patients with or without major depressive disorder: Results from a 6-month, randomized, double-blind, placebo-controlled, fixed-dose trial ☆ (2008)

The primary objectives of this study were to assess the efficacy and safety of duloxetine for reducing pain severity in fibromyalgia patients with or without current major depressive disorder. This was a 6-month, multicenter, randomized, double-blind, placebo-controlled study. In total, 520 patients meeting American College of Rheumatology criteria for fibromyalgia were randomly assigned to duloxetine (20 mg/day, 60 mg/day, or 120 mg/day) or placebo, administered once daily, for 6 months (after 3 months, the duloxetine 20-mg/day group titrated to 60 mg/day). The co-primary outcome measures were the Brief Pain Inventory (BPI) average pain severity score and Patient Global Impressions of Improvement (PGI-I) score. Safety was assessed via treatment-emergent adverse events, and changes in vital sign, laboratory, and ECG measures. Compared with placebo-treated patients, those patients treated with duloxetine 120 mg/day improved significantly more on the co-primary outcome measures at 3 months (change in BPI score [-2.31 vs -1.39, P<0.001] and PGI-I [2.89 vs 3.39, P=0.004]) and at 6 months (change in BPI [-2.26 vs -1.43, P=0.003] and PGI-I [2.93 vs 3.37, P=0.012]). Compared with placebo, treatment with duloxetine 60 mg/day also significantly improved the co-primary measures at 3 months and BPI at 6 months. Duloxetine was efficacious in patients both with and without major depressive disorder. There were no clinically significant differences between treatment groups in changes in vital signs, laboratory measures, or ECG measures. Study results demonstrated that duloxetine at doses of 60 mg/day and 120 mg/day appears to be safe and efficacious in patients with fibromyalgia.
Real-time Fall Detection with a Smartphone (2012)

In this study, a real-time fall detection system based on a smartphone equipped with three-axis accelerometer and magnetometer was proposed and evaluated. The proposed system provides a service that detects falls in real time, triggers alarm sound, and sends emergency SMS(Short Message Service) if the alarm is not deactivated within a predefined time. When both of the acceleration magnitude and angle displacement of the smartphone attached to waist belt are greater than predefined thresholds, it is detected as a fall. The proposed system was evaluated against activities of daily living(walking, jogging, sitting down, standing up, ascending stairs, and descending stairs) and unintended falls induced by a proprietary pneumatic-powered mattress. With the thresholds of acceleration magnitude 1.7g and angle displacement <TEX>$80^{\circ}$</TEX>, it showed 96.5% accuracy to detect the falls while all the activities of daily living were not detected as fall.
Intentional networking (2010)

Mobile devices face a diverse and dynamic set of networking options. Using those options to the fullest requires knowledge of application intent. This paper describes Intentional Networking, a simple but powerful mechanism for handling network diversity. Applications supply a declarative label for network transmissions, and the system matches transmissions to the most appropriate network. The system may also defer and re-order opportunistic transmissions subject to application-supplied mutual exclusion and ordering constraints. We have modified three applications to use Intentional Networking: BlueFS, a distributed file system for pervasive computing, Mozilla's Thunderbird e-mail client, and a vehicular participatory sensing application. We evaluated the performance of these applications using measurements obtained by driving a vehicle through WiFi and cellular 3G network coverage. Compared to an idealized solution that makes optimal use of all aggregated available networks but that lacks knowledge of application intent, Intentional Networking improves the latency of interactive messages from 48% to 13x, while adding no more than 7% throughput overhead.
Immunoallergic Drug-Induced Liver Injury in Humans (2009)

No conclusive data exist that define the mechanisms of idiosyncratic drug-induced liver injury (DILI) in humans; therefore, we are forced to speculate based on their clinical characteristics. The major characteristics are most easily explained by an immune mechanism. Many cases of idiosyncratic DILI tend to have a longer delay in onset and sometimes do not occur rapidly on rechallenge. These instances of DILI have been attributed to metabolic idiosyncrasy. However, these characteristics may also reflect an autoimmune mechanism, and most drugs that cause idiosyncratic DILI are also associated with various types of other autoimmune reactions. A characteristic feature of the immune system is that different individuals respond differently to the same immunogen. In some cases, a drug can induce an immune response to a reactive metabolite acting as a hapten; in others, the response is against a native protein, which leads to an autoimmune reaction. This is likely responsible for the interindividual differences in susceptibility and outcome noted in human DILI.
Morphological Control of In<sub><i>x</i></sub>Ga<sub>1–<i>x</i></sub>P Nanocrystals Synthesized in a Nonthermal Plasma (2018)

We explore the growth of InxGa1–xP nanocrystals (x = 1, InP; x = 0, GaP; and 1 > x > 0, alloys) in a nonthermal plasma. By tuning the reactor conditions, we gain control over the morphology of the final product, producing either 10 nm diameter hollow nanocrystals or smaller 3 nm solid nanocrystals. We observe the gas-phase chemistry in the plasma reactor using plasma emission spectroscopy to understand the growth mechanism of the hollow versus solid morphology. We also connect this plasma chemistry to the subsequent native surface chemistry of the nanocrystals, which is dominated by the presence of both dative- and lattice-bound phosphine species. The dative phosphines react readily with oleylamine in an L-type ligand exchange reaction, evolving phosphines and allowing the particles to be dispersed in nonpolar solvents. Subsequent treatment by HF causes the solid InP1.5 and In0.5Ga0.5P1.3 to become photoluminescent, whereas the hollow particles remain nonemissive.
Urea, creatinine, and glucose determined in plasma and whole blood by a differential pH technique. (1984)

We report the conditions (buffer composition and enzyme activity) required for estimating three frequently determined analytes--urea, glucose, and creatinine--by use of an improved version of the differential pH apparatus previously described (Clin Chem 29: 80-85, 1983). For each analyte, we used only one specific enzyme, thus avoiding a chain of auxiliary and indicator reactions. The method requires about a minute for each determination in undiluted plasma or whole blood.
The molecular biology of the positive strand RNA viruses (1987)

This book pulls together recent research findings on the molecular biology of the major families of positive strand RNA viruses infecting plants and animals. The topics covered include protein translation, processing and function, RNA replication, virus structure and antigenicity, mechanisms of infection and evolutionary relationships between the virus families.
Targeting gut microbiota in hepatocellular carcinoma: probiotics as a novel therapy (2018)

Hepatocellular carcinoma (HCC), the most common primary liver cancer, is one of the dreaded complications of chronic liver disease. Recent experimental and clinical studies have revealed that the alteration of gut-liver axis plays a pivotal role in the onset of chronic liver diseases, including HCC. Altered gut microbiota and endotoxemia are increasingly recognized as critical components in promoting the progression of chronic liver diseases to HCC. Probiotics have been suggested as a novel, safe and cost-effective approach to prevent or treat HCC. Mechanisms by which probiotics exerts their anti-cancer effects include their ability to bind carcinogens, modulation of gut microbiota, improvement of intestinal barrier function, and immunomodulation. This review summarizes the literature findings of the changes in gut microbiota linked to HCC, and discusses the possible therapeutic implications of probiotics for HCC.
Microdeletions and microinsertions causing human genetic disease: common mechanisms of mutagenesis and the role of local DNA sequence complexity (2005)

In the Human Gene Mutation Database (www.hgmd.org), microdeletions and microinsertions causing inherited disease (both defined as involving < or = 20 bp of DNA) account for 8,399 (17%) and 3,345 (7%) logged mutations, in 940 and 668 genes, respectively. A positive correlation was noted between the microdeletion and microinsertion frequencies for 564 genes for which both microdeletions and microinsertions are reported in HGMD, consistent with the view that the propensity of a given gene/sequence to undergo microdeletion is related to its propensity to undergo microinsertion. While microdeletions and microinsertions of 1 bp constitute respectively 48% and 66% of the corresponding totals, the relative frequency of the remaining lesions correlates negatively with the length of the DNA sequence deleted or inserted. Many of the microdeletions and microinsertions of more than 1 bp are potentially explicable in terms of slippage mutagenesis, involving the addition or removal of one copy of a mono-, di-, or trinucleotide tandem repeat. The frequency of in-frame 3-bp and 6-bp microinsertions and microdeletions was, however, found to be significantly lower than that of mutations of other lengths, suggesting that some of these in-frame lesions may not have come to clinical attention. Various sequence motifs were found to be over-represented in the vicinity of both microinsertions and microdeletions, including the heptanucleotide CCCCCTG that shares homology with the complement of the 8-bp human minisatellite conserved sequence/chi-like element (GCWGGWGG). The previously reported indel hotspot GTAAGT and its complement ACTTAC were also found to be overrepresented in the vicinity of both microinsertions and microdeletions, thereby providing a first example of a mutational hotspot that is common to different types of gene lesion. Other motifs overrepresented in the vicinity of microdeletions and microinsertions included DNA polymerase pause sites and topoisomerase cleavage sites. Several novel microdeletion/microinsertion hotspots were noted and some of these exhibited sufficient similarity to one another to justify terming them "super-hotspot" motifs. Analysis of sequence complexity also demonstrated that a combination of slipped mispairing mediated by direct repeats, and secondary structure formation promoted by symmetric elements, can account for the majority of microdeletions and microinsertions. Thus, microinsertions and microdeletions exhibit strong similarities in terms of the characteristics of their flanking DNA sequences, implying that they are generated by very similar underlying mechanisms.
Preparation and Kinetics of the Thermal Decomposition of Nanosized CuC2O4-ZnC2O4·2H2O (2006)

作为 CuO-ZnO 的先锋， nanosized CuC_2O_4-ZnC_2O_4 中心点 2H_2O 的物理混合被一步舞固体州反应方法在房间温度准备了。发生在纳米 CuC_2O_4-ZnC_2O_4 中心点 2H_2O 的稳固的州的盐混合的热分解过程用 TG 在静态的空中被学习了， DSC， XRD andTEM 技术。TEM 证明分解产品的谷物尺寸是 5-15 nm。活化能 E_a 的价值用 KAS 方法和 Ozawa 方法的 isoconversional 过程被决定。热分解 ofnanosized CuC_2 O_4-ZnC_2 O_4 centr 点 2H_2O 的最可能的机制功能 f (a) 用比较方法被定义， CuC_2O_4 和 ZnC_2O_4 的分解的功能模型跟随一样的机制功能“ Avrami-Erofeev 方程”。pre 指数的因素 A 根据 E_a 和 f (a) 被获得，这样热分析 nanosized CuC_2 O_4 -ZnC_2O_4centre 点 2H_2O 的分解的运动三位字节被决定。
Effect of Homogenization and Aging Treatment on Mechanical Properties and Stress-Corrosion Cracking of 7050 Alloys (2007)

The effect of homogenization and aging treatments on the strength and the stress-corrosion-cracking (SCC) resistance of the 7050 aluminum alloy has been investigated and compared with those of the same-series 7075 alloy. The recrystallized structure and the quench sensitivity are found to be significantly affected by the dispersoid distribution, depending on the homogenization conditions. The finest and densest dispersoid distribution, generated by the step-homogenization (Step-H) treatment, can effectively inhibit recrystallization to obtain the smallest fraction of recrystallized structure. Such a characteristic lowers considerably the quench sensitivity of the 7050 alloy, but it produces the reverse in the 7075 alloy. For the 7050 alloy, Step-H always exhibits the highest strength among all the aging conditions, and the proposed step-quench and aging (SQA) treatment is confirmed to achieve an optimum strength and coarsened and wide-spaced grain-boundary precipitates (GBP), which have been found to improve the resistance of the SCC by the slow-strain-rate test (SSRT). Therefore, the attainment of both optimum strength and SCC resistance is possible for the 7050 alloy via the Step-H and SQA treatment. However, such treatment is not applicable to the 7075 alloy because of its inborn high quench sensitivity.
A dendrimer‐based nanosized contrast agent dual‐labeled for magnetic resonance and optical fluorescence imaging to localize the sentinel lymph node in mice (2007)

We have successfully synthesized and tested a dual labeled MR/NIR optical hybrid contrast agent, G6-Cy5.5 for reoperative and intraoperative localization of SLNs.
Kernel methods for word sense disambiguation and acronym expansion (2006)

The scarcity of manually labeled data for supervised machine learning methods presents a significant limitation on their ability to acquire knowledge. The use of kernels in Support Vector Machines (SVMs) provides an excellent mechanism to introduce prior knowledge into the SVM learners, such as by using unlabeled text or existing ontologies as additional knowledge sources. Our aim is to develop three kernels - one that makes use of knowledge derived from unlabeled text, the second using semantic knowledge from ontologies, and finally a third, additive kernel consisting of the first two kernels - and study their effect on the tasks of word sense disambiguation and automatic expansion of ambiguous acronyms.
Pose normalization for robust face recognition based on statistical affine transformation (2003)

A framework for pose-invariant face recognition using the pose alignment method is described in this paper. The main idea is to normalize the face view in depth to frontal view as the input of face recognition framework. Concretely, an inputted face image is first normalized using the irises information, and then the pose subspace algorithm is employed to perform the pose estimation. To model the pose-invariance, the face region is divided into three rectangles with different mapping parameters in this pose alignment algorithm. So the affine transformation parameters associated with the different poses can be used to align the input pose image to frontal view. To evaluate this algorithm objectively, the views after the pose alignment are incorporated into the frontal face recognition system. Experimental results show that it has the better performance and it increases the recognition rate statistically by 17.75% under the pose that rotated within 30 degree.
A CMOS Bluetooth radio transceiver using a sliding-IF architecture (2003)

A fully integrated Bluetooth radio transceiver has been implemented in a 0.25 /spl mu/m CMOS process. A sliding-IF architecture with two-step conversion approach is used for both the receiver and transmitter. The receiver exhibits superior image-rejection performance than the low-IF receiver with out-of-band images, and suffers less DC-offset problems than the zero-IF receiver with a two-step down-conversion. The transmitter is free from the LO pulling problem. The IC achieves a sensitivity of -83 dBm and an output power of 0 dBm, both measured at the antenna port.
Implementation of open Two-Factor Authentication service applied to Virtual Private Network (2013)

For preventing the sensitive information from the malicious attackers, each layer in OSI model has its own security mechanism such as 802.1x in Data-link layer, SSL/TLS in Transport layer etc. In Network layer, IPSec, which is used to create the secure tunnel for exchanging data, is one approach to implement the so-called Virtual Private Network (VPN). In order to make VPN more secure and reliable, a strong authentication mechanism has to be applied besides the traditional username and password credentials. One of the existing methods is Two-Factor Authentication. This paper will propose the procedure to guide the one, who is willing to design and implement that service from the scratch, to build and integrate the Two-Factor Authentication Service (TFAS) into VPN system with low-cost money by the programming language-Java. The advantage of this approach is that it is too difficult to find out the ready-made system that can do the automatic real-time support; even if the commercial solution is purchased, it will be an in-a-box product which is unable to satisfy 100 percent of requirements. Additionally, for monitoring the status and health of service, the custom events such as number of login attempts exceeded, abnormal behavior of user etc. can be logged which will be valuable and useful for auditing and debugging whenever incidents occur. This idea had been applied to set up the TFAS for VPN system in the bank, it serves about 300 simultaneous users at this time.
A central role for ciliary neurotrophic factor? (1993)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
Formation of the stable bilayer assemblies in dilute aqueous solution from ammonium amphiphiles with the diphenylazomethine segment (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFormation of the stable bilayer assemblies in dilute aqueous solution from ammonium amphiphiles with the diphenylazomethine segmentToyoki Kunitake and Yoshio OkahataCite this: J. Am. Chem. Soc. 1980, 102, 2, 549–553Publication Date (Print):January 1, 1980Publication History Published online1 May 2002Published inissue 1 January 1980https://pubs.acs.org/doi/10.1021/ja00522a019https://doi.org/10.1021/ja00522a019research-articleACS PublicationsRequest reuse permissionsArticle Views362Altmetric-Citations97LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
<i>BEST1</i> gene therapy corrects a diffuse retina-wide microdetachment modulated by light exposure (2018)

Mutations in the <i>BEST1</i> gene cause detachment of the retina and degeneration of photoreceptor (PR) cells due to a primary channelopathy in the neighboring retinal pigment epithelium (RPE) cells. The pathophysiology of the interaction between RPE and PR cells preceding the formation of retinal detachment remains not well-understood. Our studies of molecular pathology in the canine <i>BEST1</i> disease model revealed retina-wide abnormalities at the RPE-PR interface associated with defects in the RPE microvillar ensheathment and a cone PR-associated insoluble interphotoreceptor matrix. In vivo imaging demonstrated a retina-wide RPE-PR microdetachment, which contracted with dark adaptation and expanded upon exposure to a moderate intensity of light. Subretinal <i>BEST1</i> gene augmentation therapy using adeno-associated virus 2 reversed not only clinically detectable subretinal lesions but also the diffuse microdetachments. Immunohistochemical analyses showed correction of the structural alterations at the RPE-PR interface in areas with <i>BEST1</i> transgene expression. Successful treatment effects were demonstrated in three different canine <i>BEST1</i> genotypes with vector titers in the 0.1-to-5E11 vector genomes per mL range. Patients with biallelic <i>BEST1</i> mutations exhibited large regions of retinal lamination defects, severe PR sensitivity loss, and slowing of the retinoid cycle. Human translation of canine <i>BEST1</i> gene therapy success in reversal of macro- and microdetachments through restoration of cytoarchitecture at the RPE-PR interface has promise to result in improved visual function and prevent disease progression in patients affected with bestrophinopathies.