gebhart/patrepeval huggingface dataset:
Mechanisms of Viral Interference with MHC Class I Antigen Processing and Presentation (1999)

Viruses are ubiquitous and dangerous obligate intracellular parasites. To facilitate recognition of virus-infected cells by the immune system, vertebrates evolved a system that displays oligopeptides derived from viral proteins on the surface of cells in association with class I molecules of the major histocompatibility complex. Here we review the mechanisms counter-evolved by viruses to interfere with the generation of viral peptides, their intracellular trafficking, or the cell surface expression of class I molecules bearing viral peptides. This topic is important in its own right because the viruses that encode these proteins represent medically important pathogens, are potential vectors for vaccines or gene therapy, and provide strategies and tools for blocking immune recognition in transplantation, autoimmunity, and gene therapy. In addition, studies on viral interference provide unique insights into unfettered antigen processing and normal cellular functions that are exploited and exaggerated by viruses.
Speech segregation based on pitch tracking and amplitude modulation (2002)

Speech segregation is an important task of auditory scene analysis (ASA), in which the speech of a certain speaker is separated from other interfering signals. D.L. Wang and G.J. Brown (see IEEE Trans. Neural Network, vol.10, p.684-97, 1999) proposed a multistage neural model for speech segregation, the core of which is a two-layer oscillator network. We extend their model by adding further processes based on psychoacoustic evidence to improve the performance. These processes include pitch tracking and grouping based on amplitude modulation (AM). Our model is systematically evaluated and compared with the Wang-Brown model, and it yields significantly better performance.
All-optical 2R regeneration at 40 Gbit/s in an SOA-based Mach-Zehnder interferometer (2003)

All-optical 2R regeneration in an SOA-based Mach-Zehnder interferometer is demonstrated at 40 Gbit/s. The regenerative capabilities combined with an input power dynamic range of 16 dB demonstrate the feasibility of this technique at very high bit rates.
Method for evaluating prediction models that apply the results of randomized trials to individual patients (2007)

The size of the benefit associated with appropriate clinical implementation of a good prediction model is sufficient to warrant development of further models. However, care is advised in the implementation of prediction modelling, especially for patients who would opt for treatment even if it was of relatively little benefit.
Technical innovation: creation of a peripheral vascularized trough to enhance healing in cryopreserved meniscal allograft reconstruction (2000)

The important functions of the meniscus have been well described. Lack of a meniscus may lead to instability and early osteoarthrosis of the knee. Meniscal transplantation is an option following complete or subtotal meniscectomy in symptomatic patients with correct alignment, and mild to moderate chondrosis with the goal of preventing further degenerative sequelae to the knee. Since the first meniscus allograft implantation was performed 1984, there have been reported several open and arthroscopic techniques. We present our technique of arthroscopically assisted transplantation of a cryopreserved meniscal allograft with special consideration given to the technical details of this procedure. This technique employs creation of a circumferential osseocancellous trough in combination with transosseous tibial tunnel fixation and arthroscopic suture passage to both secure and enhance healing of the meniscal allograft.
Assessment of bacterial endospore viability with fluorescent dyes (2004)

This study shows that fluorescence tests could be applied to assess viability in potentially pathogenic Bacillus spore preparations within 1 h.
Speeding up Array Query Processing by Just-In-Time Compilation (2008)

Interpreted languages frequently suffer from higher processing times as compared to compiled approaches. Typically this happens when complex computations are performed. Array DBMSs, which extend database functionality with multidimensional array modeling and query support, find themselves in exactly this situation: queries often involve a large number of operations, and each such operation is applied to a large number of array elements.In this paper, we propose just-in-time compilation as an optimization method for an interpreted array query language. This is achieved by grouping suitable query nodes into complex operation nodes, for which C code is generated, compiled, and loaded during runtime.We present our approach based on the array DBMS rasdaman, discuss its benefits and its embedding into the rasdaman query evaluation, and show initial, rather promising benchmark results.
General-stacking-fault energies in highly strained metallic environments:<i>Ab initio</i>calculations (2007)

Past work has shown that the generalized-stacking-fault surface energy (GSFE) curve, which represents the energy dependency of rigidly shearing an fcc crystal at a (111) plane along a $[\ensuremath{-}1\ensuremath{-}12]$ slip direction, can provide invaluable information on the nature of the dislocation activity in nanocrystalline Ni, Al, and Cu. Atomistic simulations have also revealed the complex localized strain environment in which nanocrystalline dislocation nucleation occurs. Using the density functional theory method, the present work investigates the role of an imposed isotropic and simple shear strain field on the shape of a GSFE curve for Al, Cu, and Ni, and, in particular, how this affects the ratio of the stable to unstable stacking fault surface energy. The results are discussed in terms of second and third order elasticity theories.
Monitoring the integrity of composite patch structural repair via piezoelectric actuators/sensors (1995)

Critical to the success of composite repair of metallic aircraft structures is the integrity of the bond between the base aluminum panel and the reinforcing high-strength composite patch. Monitoring of the repair is equally important to insure the composite patch integrity throughout the service life of the structure. Described in this paper are the test methods and results of a vibration signature-based technique used to qualitatively identify a de-bond on several different composite repair coupons. The high-frequency domain vibration signature from the test coupon is obtained using a single patch of piezoelectric material (Lead Zirconate Titanate or PZT), functioning both as an actuator and sensor. The vibration signature is obtained as a variation in electrical impedance of the piezoelectric patch, while driven by a fixed alternating electric field over a frequency range. The current drawn by the actuator is modulated due to the structure's inherent dynamic characteristics. The modulated electrical impedance which is analogous to the frequency response function, but much more easily obtainable, is an indication of vital dynamic structural behavior and is used to identify damage. Damage is simulated by either growing an existing pre-crack under the composite patch through cyclic loading or by creating a de-bond close to the edge of the repair patch. High frequency excitation, which is greatly facilitated by the electrically driven low-power compact PZT patch, is critical to the success of this technique because it assures a clearly visible change in the impedancelvibration signature even for very minor damage/changes. The technique has met with great success in the first stage of this development effort. Even a very minor de-bond or crack growth, has been clearly detected.
<title>Motion estimation techniques for a wavelet-based video coder</title> (1996)

Wavelet transform has been proven to be a valuable tool for image and video coding applications. Recently, a multiresolution motion estimation (MRME) technique has been proposed for wavelet-based video compression. The MRME technique estimates the motion vector hierarchically from the low resolution to the high resolution wavelet subimages, thereby reducing the computational complexity. In this paper, we propose two techniques to enhance the coding performance of the baseline MRME technique. First, we propose to use an adaptive threshold to determine whether a motion vector should be sent to the receiver resulting in a reduced number of motion vectors and hence lower bit-rate. Secondly, we propose a bi- directional motion estimation technique in the wavelet transform domain. Here, we estimate the temporal flags (direction information) only for the blocks in the lowest resolution subimages and use the same information for the corresponding blocks in the higher resolution subimages. The proposed techniques provide a superior coding performance compared to MRME technique.
Vehicle detection by means of stereo vision-based obstacles features extraction and monocular pattern analysis (2006)

This paper presents a stereo vision system for the detection and distance computation of a preceding vehicle. It is divided in two major steps. Initially, a stereo vision-based algorithm is used to extract relevant three-dimensional (3-D) features in the scene, these features are investigated further in order to select the ones that belong to vertical objects only and not to the road or background. These 3-D vertical features are then used as a starting point for preceding vehicle detection; by using a symmetry operator, a match against a simplified model of a rear vehicle's shape is performed using a monocular vision-based approach that allows the identification of a preceding vehicle. In addition, using the 3-D information previously extracted, an accurate distance computation is performed.
Transition Time of Cement Slurries, Definitions and Misconceptions, Related to Annular Fluid Migration (2004)

Abstract Transition time of cement slurries is a term that has been used throughout the oil industry for many years. During this time, the term has been defined, redefined and misused to cover a wide range of cementing topics. This has led to numerous misconceptions and confusion as to what transition time really means. For many years, this term has been directly tied to the term right-angle-set, which relates to the speed in which slurries undergoing continuous shear go from a pumpable to a non-pumpable state. Once pumping is stopped, the profile of how cement transition from a liquid, to a gel, to a set cement changes. These changes can directly affect the performance of cement slurries to control fluid migration. With the advent of the Ultrasonic Cement Analyzer (UCA), the term "transition time" of cement slurries was redefined. UCA&s have developed into an essential piece of equipment. Not only can they achieve compressive strength information, but the apparatus can also provide a continuous measurement of how cement sets in static state. This information has shortened wait on cement (WOC) time, and provides an excellent profile on how fast cement develops strength. However, the transducers in a standard UCA only provide information after the cement develops a compressive strength set. With improvement in computerization and transducers, a more sensitive evaluation of gel strength development can be studied. Another definition for transition time is the use of a static gel strength (SGS) analyzer to measure the time from which cement goes from 100 lbf/100 sq. ft (48 Pa) to 500 lbf/100 sq.ft (240 Pa). It has become an industry standard that once cement slurries reach an SGS of 500 lbf/100 sq. ft (240 Pa)., gas or other fluids cannot be transmitted through the cement. The faster that you achieve this optimum SGS, the less likely that the cement will transmit gas. This paper will establish a definition for cement transition time and discuss the misconception of only using gel strength development to control gas migration. Test data that exhibits gas tight slurries with long transition and those with short transition that allowed gas influx will be shown. Also discussed in the paper will be the advantages of cements with a short transition in controlling high-pressure water flows.
5-Substituted 2-Bromoindolo[3,2-b]quinoxalines. A Class of Potential Antitumor Agents with cdc25 Phosphatase Inhibitory Properties (1998)

Several derivatives of 5-substituted 2-bromoindolo[3,2-b]quinoxaline were synthesized and characterized. The synthesized compounds were evaluated for their antitumor activity using the National Cancer Institute-in vitro-disease oriented antitumor screen and two biochemical mechanism-based screens (cdc2 kinase and cdc25 phosphatase). Compound 19 showed broad spectrum antitumor activity with full panel (MG-MID) GI50. TGI, and LC50 of 14.2, 31.6- and 66.2 microM, respectively. In addition it inhibited cdc2 kinase and cdc25 phosphatase with IC50's of 70 and 25 microM, respectively. Thus, compound 19 represents a model for compounds with potential antitumor activity and cdc25 phosphatase inhibitory properties.
Bone Marrow Transplantation in Immunodeficiency Diseases (1996)

Bone marrow transplantation (BMT) has become the treatment of choice in an increasing number of primary immunodeficiency disorders. In many of these otherwise lethal genetic diseases, BMT can completely reverse the immunological abnormality and patients may be permanently cured. In this review, current approaches in the application of this treatment and results obtained in various entities of primary immunodeficiencies are presented. A significant prognostic factor for the outcome is the clinical condition of the patient at the time of BMT, and prompt recognition of these rare disorders remains an important prognostic factor for BMT.
Tetraethylammonium Trichloride: A Versatile Reagent for Chlorinations and Oxidations (1997)

Abstract For corrigendum see DOI: 10.1002/anie.199727111
Successive Beckmann rearrangement-alkylation sequence by organoaluminum reagents. Simple route to dl-pumiliotoxin C (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSuccessive Beckmann rearrangement-alkylation sequence by organoaluminum reagents. Simple route to dl-pumiliotoxin CKazunobu Hattori, Yasushi Matsumura, Tohru Miyazaki, Keiji Maruoka, and Hisashi YamamotoCite this: J. Am. Chem. Soc. 1981, 103, 24, 7368–7370Publication Date (Print):December 1, 1981Publication History Published online1 May 2002Published inissue 1 December 1981https://pubs.acs.org/doi/10.1021/ja00414a071https://doi.org/10.1021/ja00414a071research-articleACS PublicationsRequest reuse permissionsArticle Views724Altmetric-Citations86LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Droloxifene, A New Antiestrogen Hormonal Influences in Postmenopausal Breast Cancer Patients (1991)

Hormonal influences and pharmacokinetic aspects of the new antiestrogen droloxifene (3-hydroxytamoxifen) have been studied in a total of 148 postmenopausal patients with breast cancer. A negligible decrease in the gonadotropins LH and FSH was observed in patients treated with 20 mg (34 patients) and 40 mg (43 patients) of droloxifene (once daily). Serum concentrations of the gonadotropins obviously decreased (71 patients) with the highest dose of droloxifene (100 mg, once daily) given in this study. Sex hormone binding globulin rose only marginally in the 20- and 40-mg dose group. However, with 100 mg of droloxifene, a moderate increase was found, indicating some estrogenicity at higher doses. Rapid pharmacokinetic characteristics have been confirmed. The time to peak concentration ranges from 2 to 4 h, and the terminal half life is about 24 h, allowing interesting new schedules in endocrine therapy.
Advanced packaging materials for optical applications: bridging the gap between nm-size structures and large-area panel processing (2006)

During the last two decades, nano-materials have been intensively investigated due to their wide range of properties, resulting in a variety of applications. In order to serve as advanced packaging material, from an industrial point of view emphasis has also to be on cost reduction either for the materials, the processes, or for both. Materials are searched for which enable processing and integration from a nm up to a cm scale. A particular class of low-cost nanoscale materials fulfilling this requirement are inorganic-organic hybrid polymers (ORMOCER<sup>®</sup>)<sup>1</sup> which are synthesized by catalytically controlled hydrolysis/polycondensation reactions, resulting in storage-stable resins. Due to the variety of chemical and physical parameters, the material and processing properties which directly influence the resulting structure and thus the physical properties, can be varied over wide ranges. Upon synthesis, functional organic groups are introduced into the material which allows one to photochemically pattern the resins. The materials are capable to be patterned on a nm up to a cm scale, employing a variety of different micro- and nanopatterning methods such as, UV lithography, UV replication/lithography, laser-direct writing, or two-photon polymerization, in order to generate micro- and nano-optical components. While for most of the techniques the patterning has to be repeated several times in order to achieve multi-functional layers, the latter method allows one to directly write arbitrary 3D structures into the hybrid polymer material. The combination of chemically designed low-cost materials with tunable material parameters such as low optical absorption, tunable refractive index, good processibility, and high chemical, thermal and mechanical stability, is very attractive for (integrated) optical applications. Examples for application of the materials for microoptics as well as for optical back-planes generated by large-area processing will be given.
Experimental Investigation of a Linear 500-Element 3-Phase Charge-Coupled Device (1974)

A linear, 500-element, 3-phase charge-coupled device, originally built as a high-resolution linear image sensor, has been chosen as a representative structure for single-level, 3-phase charge-coupled devices to exemplify the performance of such devices in detail. Charge-handling ability and transfer efficiency have been studied as a function of various design parameters and operating conditions. Most of the observed functional dependences are well understood and agree with the expectations based on model calculations. However, various problems are encountered in these structures. An unusually wide spread of the performance of different devices and slow instabilities are observed. They are attributed to a lack of control of the interface potential in the gaps between the transfer electrodes. Some emphasis is placed on a more detailed description of the various measurement techniques used. These techniques are of a general interest since they are applicable to other charge-transfer devices.
Quantifying TPC-H choke points and their optimizations (2020)

TPC-H continues to be the most widely used benchmark for relational OLAP systems. It poses a number of challenges, also known as "choke points", which database systems have to solve in order to achieve good benchmark results. Examples include joins across multiple tables, correlated subqueries, and correlations within the TPC-H data set. Knowing the impact of such optimizations helps in developing optimizers as well as in interpreting TPC-H results across database systems. This paper provides a systematic analysis of choke points and their optimizations. It complements previous work on TPC-H choke points by providing a quantitative discussion of their relevance. It focuses on eleven choke points where the optimizations are beneficial independently of the database system. Of these, the flattening of subqueries and the placement of predicates have the biggest impact. Three queries (Q2, Q17, and Q21) are strongly influenced by the choice of an efficient query plan; three others (Q1, Q13, and Q18) are less influenced by plan optimizations and more dependent on an efficient execution engine.
Geolocalization Techniques using Log Files in Android (2013)

The location-sensing technology is core technology for location based services and applications. In these days Localization for mobile handset devices are gaining huge importance in various fields, they are globally useful, such as navigation, advertisements, safety security and also observation of tracking. This paper presents various techniques for location-sensing method, called a cell Id based location positioning method and its positioning accuracy estimation. In addition this paper proposed Geolocation technique which is used to track a specific user without permissions. This includes tracking, reading call history, past location history, reading SMS. To evaluate proposed system this paper implemented location-sensing technique on Android-based phones. There are different ways how information about the location of a mobile device is generated. This paper explains the state of art technology of WiFi and Cell Id based positioning and describes some of its applications. By knowing how location data is collected and processed the reader understands how location-based solutions work. Some examples are given at the end of the paper.