gebhart/patrepeval huggingface dataset:
Cardiotonic agents. 8. Selective inhibitors of adenosine 3',5'-cyclic phosphate phosphodiesterase III. Elaboration of a five-point model for positive inotropic activity (1987)

Inhibitors of adenosine 3',5'-cyclic phosphate phosphodiesterase III (cAMP PDE III) were studied by using solid-state, solution, and theoretical methods in order to refine a five-point model for positive inotropic activity. Cyclic AMP PDE III inhibitors bear a striking resemblance to cAMP itself. This investigation supports the importance of an overall planar topography for selective and potent cAMP PDE III inhibition. (Possible reasons for the potency of certain nonplanar compounds are discussed.) Cardiotonics like imazodan (1; CI-914) and 2 (CI-930) can readily achieve essentially planar geometries, as shown with X-ray crystallographic, IR, UV, NMR, and theoretical data. Small alkyl substituents that occupy space corresponding to certain portions of the cAMP sugar region increase potency (see, e.g., 2, 4). Selective inhibition of cAMP PDE III can be achieved by mimicking the attractive electrostatic potential associated with the phosphate group (e.g., with an amide) and by providing an additional attractive potential spatially opposite to the previous one, in the vicinity of the adenine N1 and extending to N3 (e.g., with an imidazole), together with a partial dipole moment comparable to the adenine dipole moment. This extends and better defines our five-point model in terms of cAMP, a natural substrate for PDE.
A Phenylboronate‐Functionalized Polyion Complex Micelle for ATP‐Triggered Release of siRNA (2012)

PIC-ing a winner: siRNA encapsulated by a phenylboronate-functionalized polyion complex (PIC) micelle shows binding between the phenylboronate and the 3′ ribose of the siRNA (see scheme), stabilizing the complex under conditions equivalent to the extracellular environment. This complex is disrupted in response to addition of ATP, at a concentration comparable to that inside cells.
Disruption of Cooperation Between Ras and MycN in Human Neuroblastoma Cells Promotes Growth Arrest (2005)

Active Ras is needed to block MycN degradation, promoting cooperative Ras- and MycN-dependent cell cycle progression in LAN-1 cells. Ras inhibitors are therefore likely candidates for the treatment of advanced neuroblastoma characterized by high expression of MycN.
Immunohistologic detection of antigen related to primate type C retrovirus p30 in normal human placentas. (1983)

This study reports the immunohistologic detection of SSAV/GaLV type C retrovirus p30-related antigen in unfixed cryostat sections of normal human term placentas by the indirect immunofluorescence method. Goat anti-SSAV p28 serum reacted specifically with 10 of 10 anatomic specimens of human placenta. Goat anti-GaLV p29 serum reacted similarly with 8 of 10 specimens. Goat anti-BaEV p28, anti-RD-114 p28, anti-FeLV p27, anti-R-MuLV p30, and anti-MPMV p27 gave no specific reaction with placenta. The anti-SSAV p28 and anti-GaLV p29 reactive antigen was located in the placenta mainly at the basal aspect of syncytiotrophoblast near the underlying trophoblastic basement membrane where type C retroviruslike particles have been found electronmicroscopically. The specific antibody activity of anti-SSAV p28 serum against placenta was removed by critical absorption with disrupted SSAV or GaLV but not RD-114 or MuLV. These results suggest the presence in human placenta of a putative type C retroviral protein which cross-reacts with the p30 protein of the SSAV/GaLV type C retrovirus group.
Smiling expression recognition: the semi-supervised haar training of a fast and frugal system (2010)

International audience
Systematic analysis of microRNA fingerprints in thrombocythemic platelets using integrated platforms (2012)

Posttranscriptional and translational controls mediated by microRNAs (miRNA) regulate diverse biologic processes. We dissected regulatory effects of miRNAs relevant to megakaryocytopoiesis and platelet biology by analyzing expression patterns in 79 subjects with thrombocytosis and controls, and integrated data with transcriptomic and proteomic platforms. We validated a unique 21-miRNA genetic fingerprint associated with thrombocytosis, and demonstrated that a 3-member subset defines essential thrombocythemia (ET). The genetic signature includes functional guide and passenger strands of the previously uncharacterized miR 490 (5p and 3p), which displayed restricted, low-level expression in megakaryocytes/platelets (compared with leukocytes), and aberrant expression during thrombocytosis, most profound in ET. Overexpression of miR 490 in a bilineage differentiation model of megakaryocyte/erythroid progenitor formation was insufficient for hematopoietic colony differentiation and/or lineage specification. Integration of transcriptomic and mass spectrometric datasets with functional reporter assays identified dishevelled associated activator of morphogenesis 1 (DAAM1) as a miR 490 5p protein target demonstrating decreased expression in ET platelets, putatively by translational control (and not by mRNA target degradation). Our data define a dysregulated miRNA fingerprint in thrombocytosis and support a developmentally restricted function of miR 490 (and its putative DAAM1 target) to conditions associated with exaggerated megakaryocytopoiesis and/or proplatelet formation.
An efficient entry to 1,2-benzisoxazoles via 1,3-dipolar cycloaddition of in situ generated nitrile oxides and benzyne (2010)

An efficient protocol for the synthesis of a range of 1,2-benzisoxazoles using an improved 1,3-dipolar cycloaddition of nitrile oxides and benzyne is described. Key to the procedure is the in situ generation of the reactive nitrile oxide and benzyne reactants simultaneously.
An <i>Arabidopsis</i> inositol phospholipid kinase strongly expressed in procambial cells: Synthesis of PtdIns(4,5)P<sub>2</sub> and PtdIns(3,4,5)P<sub>3</sub> in insect cells by 5‐phosphorylation of precursors (2001)

We have cloned a phosphatidylinositol-4-phosphate 5-kinase (PIP5K) cDNA (AtP5K1) from Arabidopsis thaliana. By the application of cell permeabilization and short-term nonequilibrium labelling we show that expression of AtP5K1 in Baculovirus-infected insect (Spodoptera frugiperda) cells directs synthesis of PtdIns(4,5)P2 and PtdIns(3,4,5)P3. The same phosphoinositides were produced by isolated whole-cell membrane fractions of AtP5K1-expressing insect cells. Their synthesis was not affected by adding defined precursor lipids, that is PtdIns(3)P, PtdIns(4)P, PtdIns(3,4)P2, or PtdIns(4,5)P2, in excess, indicating that substrates for the plant enzyme were not limiting in vivo. Enzymatic dissection of lipid headgroups revealed that AtP5K1-directed synthesis of PtdIns(4,5)P2 and PtdIns(3,4,5)P3 proceeds via 5-phosphorylation of precursors. Analysis of promoter-reporter gene (beta-glucuronidase) fusions in transgenic plants revealed that expression of the AtP5K1 gene is strongest in vascular tissues of leaves, flowers, and roots, namely in cells of the lateral meristem, that is the procambium. Single-cell sampling of sap from flower stem meristem tissue and neighbouring phloem cells, when coupled to reverse transcriptase--polymerase chain reaction, confirmed preferential expression of AtP5K1 in procambial tissue. We hypothesize that AtP5K1, like animal and yeast PIP5K, may be involved in the control of cell proliferation.
Translesion DNA polymerases in eukaryotes: what makes them tick? (2017)

Life as we know it, simply would not exist without DNA replication. All living organisms utilize a complex machinery to duplicate their genomes and the central role in this machinery belongs to replicative DNA polymerases, enzymes that are specifically designed to copy DNA. "Hassle-free" DNA duplication exists only in an ideal world, while in real life, it is constantly threatened by a myriad of diverse challenges. Among the most pressing obstacles that replicative polymerases often cannot overcome by themselves are lesions that distort the structure of DNA. Despite elaborate systems that cells utilize to cleanse their genomes of damaged DNA, repair is often incomplete. The persistence of DNA lesions obstructing the cellular replicases can have deleterious consequences. One of the mechanisms allowing cells to complete replication is "Translesion DNA Synthesis (TLS)". TLS is intrinsically error-prone, but apparently, the potential downside of increased mutagenesis is a healthier outcome for the cell than incomplete replication. Although most of the currently identified eukaryotic DNA polymerases have been implicated in TLS, the best characterized are those belonging to the "Y-family" of DNA polymerases (pols η, ι, κ and Rev1), which are thought to play major roles in the TLS of persisting DNA lesions in coordination with the B-family polymerase, pol ζ. In this review, we summarize the unique features of these DNA polymerases by mainly focusing on their biochemical and structural characteristics, as well as potential protein-protein interactions with other critical factors affecting TLS regulation.
Signal-signal crosstalk measurements in a PPLN-PPLN PSA with narrow channel spacing (2012)

We investigate inter-channel interference as a function of channel-spacing for PSAs constructed from PPLN waveguides. We use 9*50GHz spaced input channels and show that the second order non-linearity can be advantageous for multi-channel PSA applications.
Detection of the bacteriological sex factor in E. coli by matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry (1998)

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry is employed to detect the presence of the bacteriological sex factor, a trait that allows some bacteria to transfer genetic information to others by means of conjugation. The principal advantage of the method is its speed. Twenty different strains of E. coli were analyzed and the results were consistent with previously known genetic information. The sex factor could be transferred from one strain to another and the outcome verified by mass spectrometry. © 1998 John Wiley & Sons, Ltd.
Remarkably Low Catalyst Loading in Brønsted Acid Catalyzed Transfer Hydrogenations: Enantioselective Reduction of Benzoxazines, Benzothiazines, and Benzoxazinones (2006)

A highly efficient transfer hydrogenation of benzoxazines, benzothiazines, and benzoxazinones with as low as 0.01 mol % binol phosphate catalyst furnishes the dihydro-2H-benzoxazines, -benzothiazines, and -benzoxazinones in good yields and with excellent enantioselectivities (see scheme). Particularly noteworthy are the mild reaction conditions and the wide scope of substrates, including sulfur-containing compounds. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z601832_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
X-Linked Adrenoleukodystrophy (2000)

Research Articles| August 04 2010 Anatomie pathologique des cancers broncho-pulmonaires Subject Area: Further Areas , Oncology , Pathology and Cell Biology Jacques Delarue Jacques Delarue (Institut d'Anatomie pathologique, Université de Paris.) Search for other works by this author on: This Site PubMed Google Scholar Schweizerische Zeitschrift für allgemeine Pathologie und Bakteriologie (1955) 18 (4): 820–865. https://doi.org/10.1159/000160840 Article history Published Online: August 04 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Jacques Delarue; Anatomie pathologique des cancers broncho-pulmonaires. Schweizerische Zeitschrift für allgemeine Pathologie und Bakteriologie 1 April 1955; 18 (4): 820–865. https://doi.org/10.1159/000160840 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsSchweizerische Zeitschrift für allgemeine Pathologie und Bakteriologie Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1955Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
A prospective observational study of associated anomalies in Hirschsprung’s disease (2013)

Our study confirmed the underestimation of certain associated anomalies in Hirschsprung patients, such as hearing impairment and congenital anomalies of the kidney and urinary tract. Subsequently, based on our results we strongly suggest performing renal US and audiometry in all patients. Conversely, ophthalmologic assessment and cerebral and heart US can be performed according to guidelines applied to the general population or in case of patients with suspected clinical features or chromosomal abnormalities. This updated diagnostic algorithm aims at improving overall outcome thanks to better prognostic expectations, prevention strategies and early rehabilitation modalities. The investigation of genetic background of patients with associated anomalies might be the next step to explore this intriguing multifactorial congenital disease.
Formation and characterization of nanometer scale metal-oxide-semiconductor structures on GaAs using low-temperature atomic layer deposition (2005)

Atomic layer deposition (ALD) grown Al2O3 has excellent bulk and interface properties on III-V compound semiconductors and is used as gate dielectric for GaAs and GaN metal-oxide-semiconductor field-effect transistors (MOSFETs). The low-temperature (LT) ALD technology enables us to fabricate 100nm MOS structures on GaAs, defined by nanoimprint lithography. The electrical characterization of these nanostructured dielectrics demonstrates that the bulk oxide films and the oxide-GaAs interfaces are of high quality even in nanometer scale. The submicron gate length GaAs MOSFET formed by LT-ALD and lift-off process shows well-behaved transistor characteristics. This GaAs MOSFET process is ready to scale the gate length below 100nm for ultra-high-speed or THz transistor applications.
Microchannels in conventional single-mode fibers (2006)

Microchannels are fabricated into conventional single-mode fibers by femtosecond laser processing and chemical etching. Fabrication limitations imposed by the fiber geometry are highlighted and resolved through a simple technique without compromising fabrication flexibility. A microfluidic fiber device consisting of a 4 microm wide microchannel that intersects the fiber core for refractive index sensing is further demonstrated.
Neodymium YAG lasers pumped by light-emitting diodes (1981)

The results are presented of theoretical and experimental investigations of room-temperature YAG:Nd lasers pumped by light-emitting diodes. The lasing characteristics of a laser operated at the 1.06 and 1.32 µ wavelengths were investigated in the cw and pulsed regimes and dependences of its parameters on the temperature, pulse repetition frequency, and other factors were studied. In the pulsed regime the laser efficiency was 0.2% and in the cw regime the radiation power reached 50 and 17 mW at the 1.06 and 1.32 µ wavelengths, respectively.
CD-ROM And Knowledge Integration (1988)

As the title of this paper suggests, it is about CD-ROM technology and the structuring of massive databases. Even more, it is about the impact CD-ROM has had on the publication of massive amounts of information, and the unique qualities of the medium that allows for the most sophisticated computer retrieval techniques that have ever been used. I am not drawing on experience as a pedant in the educational field, but rather as a software and database designer who has worked with CD-ROM since its inception. I will be giving examples from my company's current applications, as well as discussing some of the challenges that face information publishers in the future. In particular I have a belief about what the most valuable outlet can be created using CD-ROM will be: The CD-ROM is particularly suited for the mass delivery of information systems and databases that either require or utilize a large amount of computational preprocessing to allow a real-time or interactive response to be achieved. Until the advent of CD-ROM technology this level of sophistication in publication was virtually impossible. I will further explain this later in this paper. First, I will discuss the salient features of CD-ROM that make it unique in the world of data storage for electronic publishing.
Expert recommender systems in practice (2009)

Expert recommender systems (ERS) are considered a promising technology in knowledge management. However, there are very few studies which evaluated their appropriation in practice. In this paper, we present results of a case study of expert recommender technology in a large European industrial association. Unlike existing expert recommender approaches, the system involves users in selecting textual documents for semi-automatic profile generation. Our study focuses on the appropriation of this functionality and discusses impacts from an organizational perspective.
Specific Cytoplasmic Glucocorticoid Hormone Receptors in Hepatoma Tissue Culture Cells (1971)

Kinetic and equilibrium studies are presented for the reversible binding of [(3)H]dexamethasone by "specific" macromolecular receptors in the cytoplasmic fraction of cultured rat hepatoma cells. As in the case of the nuclear receptors in the same cells, the binding affinities of various steroids for the cytoplasmic receptors are closely correlated with the activities of these compounds as inducers of both tyrosine aminotransferase (EC 2.6.1.5) and cell adhesiveness. This suggests that the binding reaction is important for the biological effects of the hormones. Steroid-binding activity is inhibited by various proteases, mercurials, and 1 M KCl, but not by DNase or RNase. The receptors sediment in sucrose gradients in 0.5 M KCl near 4S, and at lower ionic strength near 7S; some of their physical properties are altered upon binding steroid. Bound dexamethasone can be recovered from the receptors as the unaltered steroid.
Mapping the coronary arteries on a sphere in CT angiography (2004)

Current approaches for coronary artery inspection using cardiac CT angiography scans include curved planar reformation (CPR), slab maximum-intensity projection (MIP) and volume rendering (VR) techniques. While the first two allow a detailed examination of only one vessel or a few segments of the coronary artery tree at a time, the VR techniques are not considered suitable for a thorough clinical assessment. An innovative concept of visualization aimed at revealing the entire coronary tree in a CPR-type environment is presented. The new approach uses a sphere or an ellipsoid as a base surface to map the coronary tree. Using the spherical (or ellipsoidal) coordinate system a “true” surface running through the centerlines of all the vessels is defined. Resampling the volume data with this (preferably thick) surface and using a maximum-intensity projection will produce three possible modes of visualization. In one mode the “true form” surface is texture-mapped with the resampled volume data, while in another the data is projected onto the sphere that served as a base surface, forming the “Globe” mode of visualization. Peeling the data to form a 2D “map” of the entire coronary tree in its context in the heart constitutes the third mode.
Dynamic-Moving-Window Scheme for Virtual-Metrology Model Refreshing (2012)

Virtual metrology (VM) is a method to conjecture manufacturing quality of a process tool based on data sensed from the process tool without physical metrology operations. Historical data is used to produce the initial VM models, and then these models are applied to operating in a process drift or shift environment. The accuracy of VM highly depends on the modeling samples adopted during initial-creating and online-refreshing periods. Since large resources are required, design-of-experiments may not be performed. In that case, how could we guarantee the stability of the models and predictions as they move into the unknown environment? Conventionally, static-moving-window (SMW) schemes with a fixed window size are adopted in the online-refreshing period. The purpose of this paper is to propose a dynamic-moving-window (DMW) scheme for VM model refreshing to enhance prediction accuracy. The DMW scheme adds a new sample into the model and applies a clustering technology to do similarity clustering. Next, the number of elements in each cluster is checked. If the largest number of the elements is greater than the predefined threshold, then the oldest sample in the cluster with the largest population is deleted. Both the adaptive-resonance-theory-2 and the newly proposed weighted-Euclidean-distance methods are applied to do similarity clustering.