gebhart/patrepeval huggingface dataset:
Variable optical power splitter based on slot waveguide (2009)

To meet the application demand of optical communication system, a new type of variable optical power splitter (VOPS) based on slot waveguide by adjusting manually is proposed in this paper. The device is designed by using the principle of optical field effect. It has an import port which provides import power, and two output ports, the power of which is divided dynamically by changing the width of the gap between two slot waveguides. This paper can specify the operation principle of the device, test its important technical indicators and analyze experimental datum. Experimental results show that the device can realize light distribution of the single wavelength and multiple wavelengths and that the power splitting ratio is dynamically tunable and the tuning range can be 1-25dB, which ensures rapid organization and deployment of communication network.
Is nitric oxide involved in cutaneous vasodilation during body heating in humans? (1994)

The neurotransmitter responsible for neurogenic vasodilation in human skin during body heating is unknown. We sought to determine whether the vasodilating substance nitric oxide (NO) is involved in this phenomenon. Six subjects were heated for 50 min by use of a water-perfused suit while forearm blood flow (FBF) was measured with plethysmography and skin blood flow (SkBF) was measured by the laser-Doppler method in both arms. In one forearm, NG-monomethyl-L-arginine (L-NMMA), an NO synthase blocker, was infused into the brachial artery. Bolus doses of L-NMMA (< or = 4 mg/min) for 5 min were given to blunt NO-mediated vasodilator responses to acetylcholine (ACh, 64 micrograms/min). A continuous infusion of L-NMMA (< or = 1.0 mg/min) was used during body heating to maintain NO synthase blockade. In the forearm receiving L-NMMA, FBF was 1.8 +/- 0.3 ml.100 ml-1.min-1 before drug infusion and rose to 9.5 +/- 1.3 ml.100 ml-1.min-1 with ACh. After L-NMMA infusion, FBF was 1.3 +/- 0.2 ml.100 ml-1.min-1 and rose to 2.6 +/- 0.4 ml.100 ml-1.min-1 with ACh (both P < 0.05 vs. pre-L-NMMA). Similar changes in SkBF were seen with ACh and L-NMMA, confirming that the drugs reached cutaneous vessels. With body heating, oral temperature increased by 1.2 degrees C, heart rate increased by 34 beats/min, and mean arterial pressure remained constant at approximately 75 mmHg. FBF in the treated forearm rose to 11.5 +/- 2.1 vs. 12.6 +/- 1.7 ml.100 ml-1.min-1 in the control forearm (P > 0.05, control vs. treated response).(ABSTRACT TRUNCATED AT 250 WORDS)
Transition Metal Complexes of Tetraethylenepentamine. I. Preparation, Properties, and Geometric Configuration of α- and β-Chlorotetraethylenepentaminecobalt (III) Tetrachlorozincate (II) and the α Chromium(III) Analog (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTransition Metal Complexes of Tetraethylenepentamine. I. Preparation, Properties, and Geometric Configuration of α- and β-Chlorotetraethylenepentaminecobalt (III) Tetrachlorozincate (II) and the α Chromium(III) AnalogD. A. House and Clifford S. GarnerCite this: Inorg. Chem. 1966, 5, 12, 2097–2102Publication Date (Print):December 1, 1966Publication History Published online1 May 2002Published inissue 1 December 1966https://pubs.acs.org/doi/10.1021/ic50046a003https://doi.org/10.1021/ic50046a003research-articleACS PublicationsRequest reuse permissionsArticle Views148Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Abstract 1584: Targeting the mitotic checkpoint with inhibition of MPS1 kinase enhances radiosensitivity of glioblastoma cancer cells. (2013)

Abstract During the cell cycle, genomic stability requires accurate chromosome segregation. Errors in this process can cause aneuploidy and lead to tumorigenesis. To ensure faithful chromosome segregation, cells develop a mechanism called the spindle assembly checkpoint (SAC). Cancer cells are addicted to the components of SAC machinery for a faithful entry of the cell into anaphase. Thus, targeting the molecular mechanisms required for the growth of aneuploid cells may be a more cancer cell specific therapeutic approach applicable to broader tumor histologies. Previously, using a siRNA based RNAi screen we identified MPS1 kinase, (also known as TTK) as an important kinase for GBM cell survival. MPS1 is an essential SAC enzyme aberrantly overexpressed in a wide range of tumors and necessary for tumor cell proliferation. We observed inhibition of GBM cell growth when MPS1 was downregulated by number of MPS1 specific siRNAs. This was further validated using a selective and orally bioavailable MPS1 inhibitor NMS-P715 in various in-vitro cell assays. The inhibition of cell death was induced partly by apoptosis; however, the major mechanism was mitotic catastrophe. Cells treated with NMS-P715 showed an increase in cells in G2-M phase of cell cycle compared to control cells followed by mitotic catastrophe. Moreover, inhibition of MPS1 resulted in radiosensitization of GBM cells. We observed decrease in DNA damage repair and significant retention of γH2AX foci after combination of radiation (RT) with NMS-P715 compared to individual treatments. Next, radiation in combination with NMS-P715 inhibited cell survival ability of GBM cells in a colony formation assay. Further, NMS-P715 could inhibit GBM tumor growth in an orthotopic brain tumor model. Finally, in order to determine MPS1 associated molecular pathways, we compared gene expression profile in MPS1 knockdown cells compared to the control by microarray analysis. Ingenuity pathway and Gene Set Enrichment Analysis were used to investigate the biological relevance of the MPS1 modulated genes. We identified genes important in cell assembly, cell organization, DNA repair and cell death pathways. Thus, inhibiting MPS1 kinase in combination with radiation could represent a promising new approach to GBM therapy. Citation Format: Anita T. Tandle, Ryan Hanson, Uday B. Maachani, Tamalee Meushaw, Shuping Zhao, Uma Shankavaram, Philip Tofilon, Natasha J. Caplen, Kevin Camphausen. Targeting the mitotic checkpoint with inhibition of MPS1 kinase enhances radiosensitivity of glioblastoma cancer cells. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1584. doi:10.1158/1538-7445.AM2013-1584
EXPRESSION OF HLA-DR ON T LYMPHOCYTES FOLLOWING RENAL TRANSPLANTATION, AND ASSOCIATION WITH GRAFT-REJECTION EPISODES AND CYTOMEGALOVIRUS INFECTION (1984)

The expression of HLA-DR by T lymphocyte subpopulations recognized by monoclonal antibodies and flow cytometry was monitored in 10 normal controls, 15 patients on hemodialysis, 25 recipients of a renal allograft with stable graft function, 16 transplant recipients suffering rejection episodes, and 4 transplant recipients with cytomegalovirus (CMV)4 infection. No significant differences in HLA-DR expression were observed in the OKT4-reactive subpopulation among these controls and patients. In the 16 patients who suffered rejection episodes a significant increase in HLA-DR expression by OKT8-reactive cells was observed. In the 10 patients in whom rejection episodes occurred later than 1 week after transplantation, the percentage of OKT8-reactive cells that expressed HLA-DR was dramatically increased 2-6 days before the onset of clinical symptoms of rejection (P less than 0.001 Student's t test). When the rejection episode responded to treatment, expression of HLA-DR on the OKT8-reactive cells decreased--whereas in 3 patients who lost their grafts because of irreversible rejection, expression of HLA-DR remained elevated. In addition, the 4 patients with CMV infection had increased percentages of OKT8-reactive cells that expressed HLA-DR (P less than 0.001 Student's t test). This increase in expression of HLA-DR coincided with the onset of clinical symptoms of the CMV infection, and the expression of HLA-DR returned to normal values after the titers of antibodies to CMV had increased significantly and symptoms of infection had disappeared.
Growing solver-aided languages with rosette (2013)

SAT and SMT solvers have automated a spectrum of programming tasks, including program synthesis, code checking, bug localization, program repair, and programming with oracles. In principle, we obtain all these benefits by translating the program (once) to a constraint system understood by the solver. In practice, however, compiling a language to logical formulas is a tricky process, complicated by having to map the solution back to the program level and extend the language with new solver-aided constructs, such as symbolic holes used in synthesis.
Vitamin A in serum is a survival factor for fibroblasts (1997)

Murine 3T3 cells arrest in a quiescent, nondividing state when transferred into medium containing little or no serum. Within the first day after transfer, fibroblasts can be activated to proliferate by platelet-derived growth factor (PDGF) alone; cells starved longer than 1 day, however, are activated only by serum. We demonstrate that endogenous vitamin A (retinol) or retinol supplied by serum prevents cell death and that retinol, in combination with PDGF, can fully replace serum in activating cells starved longer than 1 day. The physiological retinol derivative 14-hydroxy-4, 14-retro-retinol, but not retinoic acid, can replace retinol in rescuing or activating 3T3 cells. Anhydroretinol, another physiological retinol metabolite that acts as a competitive antagonist of retinol, blocks cell activation by serum, indicating that retinol is a necessary component of serum. It previously has been proposed that activation of 3T3 cells requires two factors in serum, an activation factor shown to be PDGF and an unidentified survival factor. We report that retinol is the survival factor in serum.
Flick-and-brake (2011)

We present two variants of Flick-and-Brake, a technique that allows users to not only trigger motion by touch-screen flicking but also to subsequently modulate scrolling speed by varying pressure of a stationary finger. These techniques, which further exploit the metaphor of a massive wheel, provide the user with online friction control. We describe a finite-state machine that models a variety of flicking interaction styles, with or without pressure control. We report the results of a preliminary user study that suggests that for medium to long distance scrolling the Flick-and-Brake techniques require less gestural activity than does standard flicking. One of the two variants of the technique is faster, but no less accurate, than state-of-the-art flicking. Users also reported they preferred Flick-and-Brake over the standard flick and judged it more efficient. We indicate some pending issues raised by the results of this preliminary investigation.
Cascading of tenant SDN and cloud controllers for 5G network slicing using Transport API and Openstack API (2017)

Cascading of network and cloud resources is defined as the recursive hierarchical abstraction and virtualization of resources. Cascading is expected to an enabler for 5G Network Slicing. We provide a demonstration of the proposed concept.
An integrated approach to correction for off-resonance effects and subject movement in diffusion MR imaging (2015)

In this paper we describe a method for retrospective estimation and correction of eddy current (EC)-induced distortions and subject movement in diffusion imaging. In addition a susceptibility-induced field can be supplied and will be incorporated into the calculations in a way that accurately reflects that the two fields (susceptibility- and EC-induced) behave differently in the presence of subject movement. The method is based on registering the individual volumes to a model free prediction of what each volume should look like, thereby enabling its use on high b-value data where the contrast is vastly different in different volumes. In addition we show that the linear EC-model commonly used is insufficient for the data used in the present paper (high spatial and angular resolution data acquired with Stejskal-Tanner gradients on a 3T Siemens Verio, a 3T Siemens Connectome Skyra or a 7T Siemens Magnetome scanner) and that a higher order model performs significantly better. The method is already in extensive practical use and is used by four major projects (the WU-UMinn HCP, the MGH HCP, the UK Biobank and the Whitehall studies) to correct for distortions and subject movement.
THE EFFECT OF ADENO-ASSOCIATED VIRUS MEDIATED BRAIN DERIVED NEUROTROPHIC FACTOR IN AN ANIMAL MODEL OF NEUROGENIC IMPOTENCE (2001)

Intracavernous injection of adeno-associated virus-brain derived neurotrophic factor may prevent the degeneration of neuronal nitric oxide synthase containing neurons in the major pelvic ganglia and facilitate the regeneration of neuronal nitric oxide synthase containing nerve fibers in penile tissue, thus, enhancing the recovery of erectile function after bilateral cavernous nerve injury.
North American Co-operative Bird Migrating Study 1957 (1957)

BirdMigrating Study -1957 We hope most of our members will I ke part in this year's bird migraj; m study-in co-operation with bird atchers across the continent.In idition to the first seen dates, j take note of any heavy migration i aves for the species involved.When
Reordering for Improved Constrained Reconstruction from Undersampled k‐Space Data (2008)

Recently, there has been a significant interest in applying reconstruction techniques, like constrained reconstruction or compressed sampling methods, to undersampled k-space data in MRI. Here, we propose a novel reordering technique to improve these types of reconstruction methods. In this technique, the intensities of the signal estimate are reordered according to a preprocessing step when applying the constraints on the estimated solution within the iterative reconstruction. The ordering of the intensities is such that it makes the original artifact-free signal monotonic and thus minimizes the finite differences norm if the correct image is estimated; this ordering can be estimated based on the undersampled measured data. Theory and example applications of the method for accelerating myocardial perfusion imaging with respiratory motion and brain diffusion tensor imaging are presented.
Effects of Changing from Oral to Subcutaneous Methotrexate on Red Blood Cell Methotrexate Polyglutamate Concentrations and Disease Activity in Patients with Rheumatoid Arthritis (2011)

Changing to SC MTX results in increased long-chain MTXGlu(n). However, it takes at least 6 months for RBC steady-state concentrations to be achieved. Increased long-chain MTXGlu(n) concentrations were significantly associated with reduced disease activity.
Rare earth chelates of 1,1,1,2,2,3,3-heptafluoro-7,7-dimethyl-4,6-octanedione (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRare earth chelates of 1,1,1,2,2,3,3-heptafluoro-7,7-dimethyl-4,6-octanedioneCharles S. Springer Jr., Devon W. Meek, and Robert E. SieversCite this: Inorg. Chem. 1967, 6, 6, 1105–1110Publication Date (Print):June 1, 1967Publication History Published online1 May 2002Published inissue 1 June 1967https://pubs.acs.org/doi/10.1021/ic50052a009https://doi.org/10.1021/ic50052a009research-articleACS PublicationsRequest reuse permissionsArticle Views497Altmetric-Citations166LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Good Laboratory Practices for Waived Testing Sites: Survey Findings from Testing Sites Holding a Certificate of Waiver Under the Clinical Laboratory Improvement Amendments of 1988 and Recommendations for Promoting Quality Testing (2005)

Under the Clinical Laboratory Improvement Amendments of 1988 (CLIA), simple, low-risk tests can be waived and performed with no routine regulatory oversight in physicians' offices and various other locations. Since CLIA was implemented, waived testing has steadily increased in the United States. Surveys conducted during 1999-2004 by the Centers for Medicare & Medicaid Services and studies funded by CDC during 1999-2003 evaluated testing practices in sites holding a CLIA Certificate of Waiver (CW). Although study findings indicate CW sites generally take measures to perform testing correctly, they raise quality concerns about practices that could lead to errors in testing and poor patient outcomes. These issues are probably caused, in part, by high personnel turnover rates, lack of understanding about good laboratory practices, and inadequate training. This report summarizes study findings and provides recommendations developed by the Clinical Laboratory Improvement Advisory Committee for conducting quality waived testing. These recommendations include considerations before introducing waived testing, such as management responsibility for testing, regulatory requirements, safety, physical and environmental requirements, benefits and costs, staffing, and documentation. They also cover good laboratory practices for the three phases of testing: 1) before testing (test ordering and specimen collection), 2) during testing (control testing, test performance, and result interpretation and recording), and 3) after testing (result reporting, documentation, confirmatory testing, and biohazard waste disposal). They are intended to be used by those who would benefit from improving their knowledge of good laboratory practices. Continued monitoring of waived testing, with a focus on personnel education and training, is needed to improve practices and enhance patient safety as waived testing continues to increase.
A Brief History of Connectionism (1998)

Connectionist research is firmly established within the scientific community, especially within the multi-disciplinary field of cognitive science. This diversity, however, has created an environment which makes it difficult for connectionist researchers to remain aware of recent advances in the field, let alone understand how the field has developed. This paper attempts to address this problem by providing a brief guide to connectionist research. The paper begins by defining the basic tenets of connectionism. Next, the development of connectionist research is traced, commencing with connectionism’s philosophical predecessors, moving to early psychological and neuropsychological influences, followed by the mathematical and computing contributions to connectionist research. Current research is then reviewed, focusing specifically on the different types of network architectures and learning rules in use. The paper concludes by suggesting that neural network research—at least in cognitive science—should move towards models that incorporate the relevant functional principles inherent in neurobiological systems. 1 The Connectionist Revolution This solution takes the form of a new associationism, or better, since it differs deeply and widely from that older British associationism, of a new connectionism. ([109], p. 4) Connectionist research is firmly established within the scientific community. Researchers can be found in such fields as artificial intelligence [33][1], cognitive neuroscience [76], economics [117][121], linguistics [84], philosophy [48], and physics [47] to name but a few. It has even been suggested that connectionism represents a Kuhnian-like paradigm shift for psychology [98].
Complexes of technetium with hydroxycarboxylic acids: gluconic, glucoheptonic, tartaric, and citric. (1980)

Technetium complexes of several hydroxycarboxylic acids are used for medical imaging. To determine the oxidation state of technetium in these agents, we studied the reduction of pertechnetate (Tc-99) in 0.1 M solutions of four hydroxycarboxylic acids, using polarography and amperometric titration with Sn(II). In D-gluconate below pH 6, Tc(III) and Tc(V) complexes were identified with certainty, Tc(IV) questionably; at pH 6 to 10, Tc(IV) and Tc(V) were formed; above pH 10, Tc(III), Tc(IV), and Tc(V). In D-glucoheptonate below pH 6, Tc(III) and Tc(V) were formed, and questionably Tc(IV); at pH 6 to 10, Tc(V); above pH 10, Tc(III), Tc(V), and probably Tc(IV). In L-tartrate below pH 6, Tc(III), Tc(IV), and Tc(V) were formed; above pH 6, Tc(IV) and Tc(V). In citrate below pH 10, Tc(III), Tc(IV), and Tc(V) were formed; above pH 10, Tc(IV) and Tc(V). For all four ligands the initial product of reduction by Sn(II) at pH 3 to 9 was Tc(V). In freshly prepared tin-labeled imaging agents of this class, the oxidation state is probably Tc(V). Lower stable oxidation states exist, attainable by using reducing agents stronger than tin; these may show altered imaging properties.
Induction of genomic instability in SV40 transformed human cells: sufficiency of the N-terminal 147 amino acids of large T antigen and role of pRB and p53. (1994)

Genomic instability is an early event in the transformation of human cells by SV40 and may contribute, as a mutagenic process, to the generation of the rare cells which survive crisis and yield immortal populations. We have previously reported that expression of large T antigen is responsible for induction of chromosome aberrations and aneuploidy. In the present study we have demonstrated that the amino terminal 147 amino acids of the protein are as proficient as full length T antigen for this destabilization of the cell genome. Analysis of mutants within this region indicated that T antigens defective for binding to pRB or lacking the first 127 amino acids are significantly reduced in their ability to induce aneuploidy and/or aberrations, whereas a cytoplasmic T antigen is less severely impaired. In addition, we have shown that binding of T antigen to p53 is dispensable for genome destabilization but may be required for continued proliferation of genetically aberrant cells.