gebhart/patrepeval huggingface dataset:
Antimicrobial properties of green tea catechins (2005)

Extracts of leaves from the tea plant Camellia sinensis contain polyphenolic components with activity against a wide spectrum of microbes. Studies conducted over the last 20 years have shown that the green tea polyphenolic catechins, in particular (-)-epigallocatechin gallate (EGCg) and (-)-epicatechin gallate (ECg), can inhibit the growth of a wide range of Gram-positive and Gram-negative bacterial species with moderate potency. Evidence is emerging that these molecules may be useful in the control of common oral infections, such as dental caries and periodontal disease. Sub-inhibitory concentrations of EGCg and ECg can suppress the expression of bacterial virulence factors and can reverse the resistance of the opportunistic pathogen Staphylococcus aureus to beta-lactam antibiotics. For example, relatively low concentrations of ECg can sensitize methicillin-resistant S. aureus (MRSA) clinical isolates to levels of oxacillin that can be readily achieved in clinical practice. Catechin gallates such as ECg intercalate into phopsholipid bilayers and it is likely that they affect both virulence and antibiotic resistance by perturbing the function of key processes associated with the bacterial cytoplasmic membrane.
Ezymatic changes in serum and tissues in fowl infected with a neurotropic‐mesogenic strain of Newcastle disease virus (1982)

Chickens aged 6 weeks were inoculated intravenously with two strains of Newcastle disease virus: a mesogenic strain (MAJ) with relatively high neurotropism and a lentogenic strain (V5K7E1). The levels of several enzymes were determined in serum and in various tissues of the infected birds. A marked increase in lactic dehydrogenase (LDH) level in skeletal muscles and a decrease of LDH activity in liver were found in chickens infected with the MAJ strain. Differentiation of LDH isoenzymes by either heating or electrophoresis indicated a significant elevation of LDH 5 iso-enzyme in breast muscle and of LDH 1 in leg muscle, while the activity of LDH 1 in liver decreased. Similar changes were found in the activity of hydroxy butyrate dehydrogenase. Infection with the MAJ strain caused an increase of acid phosphatase activity in breast muscle, a marked decrease of alkaline phosphatase and malate dehydrogenase and an increase of glutamate-oxaloacetate transaminase activities in the intestine. These findings indicate the origin of the changes in enzyme levels found in serum. The possibility of metabolic changes in muscles and liver resulting from damage to the central nervous system is discussed. Inoculation of chickens with the lentogenic strain produced no significant change in the enzyme profile of tissues and serum.
Considerations in Platinum and Gold Drug Design and the Synthesis of Chloro(2,3‐Diphenyl‐1,3,4‐Thiadiazolium‐5‐Thiolato‐<i>S</i><sub><i>e</i><i>x</i><i>o</i></sub>)Gold(I): The First Gold Meso‐Ionic Complex of Its Kind (1997)

It is evident that the chemistry of platinum is in a more advanced state than that of gold, mainly due to the success of the former in several anti-cancer drugs. With a view to finding possible, new candidates with chemotherapeutic potential, the use of sulphur-donor ligands bonded to platinum and gold is discussed herein in an attempt to promote the need to investigate similar ligands. Chloro(2,3-diphenyl-1,3,4-thiadiazolium-5-thiolato-S(exo))gold(I) has been synthesised using a standard reaction, whereby Au(III) is initially reduced to Au(I) then reacted with the ligand, 2,3-diphenyl-1,3,4-thiadiazolium-5-thiolate.hydrochloride, isolated and finally characterised by elemental analyses and infrared spectroscopy. The compound is the first example of gold attached to a meso-ionic compound. It has also been tested for anti-bacterial and anti-fungal activity and shown to possess moderate activity against Gram-positive bacteria, although is inactive against, Gram-negative bacteria and fungi.
Star-Shaped Polycyclic Aromatics Based on Oligothiophene-Functionalized Truxene:  Synthesis, Properties, and Facile Emissive Wavelength Tuning (2003)

A facile approach to soluble star-shaped oligothiophene-functionalized polycyclic aromatics based on truxene is developed in this Communication. The Suzuki coupling reactions afford the thiophene-containing polycyclic aromatics with long branches (about 2.1 nm length from the heart to the periphery) from truxene precursor with excellent yields. The unsubstituted alpha-positions of thiophene rings allow for efficient halogenation and for further functionalization. The investigation of proton NMR spectra indicates that the hexahexyl groups efficiently prevent the self-association through the arene-arene pi-stacking. Chemical shifts belonging to methylene groups move more upfield than do those of methyl groups. These chemical shift values (about 0.5-0.6 ppm) are quite lower than those of normal methyl and methylene groups. We also prepare a dendritic hyperbranched polymer P1 through FeCl3 mediated oxidative polymerizations. The photophysical properties of all compounds possessing good symmetry are investigated by UV-vis and emission measurement.
Breast Mass Characterization Using 3‐Dimensional Automated Ultrasound as an Adjunct to Digital Breast Tomosynthesis (2013)

In this initial reader study, no significant difference in ROC performance was found with the addition of 3D-AUS to DBT. However, a trend to improved discrimination of malignancy was observed when adding 3D-AUS. Radiologists' confidence also improved with DBT/3DAUS compared to DBT alone.
Dual route and connectionist models of reading: an overview (2006)

Reading researchers seek to discover exactly what kinds of information-processing activities go on in our minds when we read; to discover what the structure and organization is of the cognitive system skilled readers have acquired from learning to read. Little is known about how the most elaborate aspects of this system work, but much has been learned about its basic building blocks such as letter identification, visual word recognition and knowledge of letter-sound rules. I contrast two approaches to theorizing about these basic reading components, the dual route approach and the connectionist approach, and offer reasons for believing that the dual route approach is to be preferred.
The mitotic spindle is required for loading of the DASH complex onto the kinetochore (2002)

A role for the mitotic spindle in the maturation of the kinetochore has not been defined previously. Here we describe the isolation of a novel and conserved essential gene, ASK1, from Saccharomyces cerevisiae involved in this process. ask1 mutants display either G(2)/M arrest or segregation of DNA masses without the separation of sister chromatids, resulting in massive nondisjunction and broken spindles. Ask1 localizes along mitotic spindles and to kinetochores, and cross-links to centromeric DNA. Microtubules are required for Ask1 binding to kinetochores, and are partially required to maintain its association. We found Ask1 is part of a multisubunit complex, DASH, that contains approximately 10 components, including several proteins essential for mitosis including Dam1, Duo1, Spc34, Spc19, and Hsk1. The Ipl1 kinase controls the phosphorylation of Dam1 in the DASH complex and may regulate its function. We propose that DASH is a microtubule-binding complex that is transferred to the kinetochore prior to mitosis, thereby defining a new step in kinetochore maturation.
Feasibility of Estimating Cu Contamination in Floodplain Soils using VNIR Spectroscopy—A Case Study in the Le’an River Floodplain, China (2012)

Heavy metal accumulation can influence the physical, chemical, and ecological processes in the soil ecosystem, and the accumulation of heavy metals has become a serious environmental issue in China, especially in the floodplains downstream from mining and smelting sites. A novel method of estimating the heavy metal contamination of soil is proposed using visible and near-infrared (VNIR) spectroscopy and partial least squares regression (PLSR). Our study focuses on the Le’an river floodplain, Jiangxi Province, China, which houses the largest copper mining operation in China and has suffered a series of environmental setbacks from the extraction of copper. Our study employs PLSR to summarize the relationship between VNIR reflectance spectra and the copper content of collected soil samples, and then estimates copper contamination of the soil using VNIR spectroscopy and the calibrated model. More specifically, with 71 soil samples collected from the Le’an River floodplain, our study aims at (1) exploring the correlation between VNIR and soil constituents, including soil organic matter, total copper, and iron content; (2) assessing the relationship between VNIR determination of copper and the pre-processing of soil samples; and (3) evaluating the performance of data transformation methods in PLSR. The correlation analysis revealed that the mechanism of estimating Cu content lay in its correlation with Fe content. The PLSR model with logarithmic scale transformed copper content and the standard normal variate spectra was chosen for estimating copper contamination from untreated soil samples; the model with logarithmic scale transformed copper content and reflectance spectra was selected for pretreated soil samples. The correlation analyses and regression results in the PLSR models both suggest that the main mechanism for estimating Cu content in this case study lies in its correlation with Fe content. Therefore, the coupling of VNIR spectroscopy and PLSR could serve as an alternative method of monitoring heavy metal contamination of soil.
Resolution of branched-chain oxo acid dehydrogenase complex of <i>Pseudomonas aeruginosa</i> PAO. (1986)

Branched-chain oxo acid dehydrogenase was purified from Pseudomonas aeruginosa strain PAO with the objective of resolving the complex into its subunits. The purified complex consisted of four proteins, of Mr 36,000, 42,000, 49,000 and 50,000. The complex was resolved by heat treatment into the 49,000 and 50,000-Mr proteins, which were separated by chromatography on DEAE-Sepharose. The 49,000-Mr protein was identified as the E2 subunit by its ability to catalyse transacylation with a variety of substrates, with dihydrolipoamide as the acceptor. P. aeruginosa, like P. putida, produces two lipoamide dehydrogenases. One, the 50,000-Mr protein, was identified as the specific E3 subunit of branched-chain oxo acid dehydrogenase and had many properties in common with the lipoamide dehydrogenase LPD-val of P. putida. The second lipoamide dehydrogenase had Mr 54,000 and corresponded to the lipoamide dehydrogenase LPD-glc of P. putida. Fragments of C-terminal CNBr peptides of LPD-val from P. putida and P. aeruginosa corresponded closely, with only two amino acid differences over 31 amino acids. A corresponding fragment at the C-terminal end of lipoamide dehydrogenase from Escherichia coli also showed extensive homology. All three peptides had a common segment of eight amino acids, with the sequence TIHAHPTL. This homology was not evident in any other flavoproteins in the Dayhoff data base which suggests that this sequence might be characteristic of lipoamide dehydrogenase.
The Legacy of Tamar: Courage and Faith in an African American Family (2002)

Tracing the story of five generations of an African American family in the rural South, The Legacy of Tamar is a moving testament to the resilience and triumph of the human spirit. In documenting the struggles of the Taylor-Springfield family, it also explores the fascinating history of Haywood County, Tennessee, where blacks have outnumbered whites almost two to one. Raye Springfield begins her family history in 1913, when Polk Taylor had a dream that foretold the deaths of five family members. After his death, Taylor's widow, Tamar, accepted the role of family matriarch. The Taylor and Springfield families were subsequently joined when Tamar's granddaughter, Opal, married Tonnie Springfield. The book then follows this family, among the few black landowners in the county, as they endeavored to maintain their farm and their bonds of kinship in the face of significant change--most notably the great northern migration. As the author shows in rich detail, the social upheavals in Haywood County brought on by the diminished interest in farming mirrored the national disruptions that occurred with the shift from a largely rural, agricultural society to an urban, industrial one. The Legacy of Tamar spans two world wars, the Great Depression, and the Civil Rights era, showing how the family retained their dreams for a better future in an area where every effort--both social and legal--was exercised to control the large African American population. For this family, strong religious faith and a fervent belief in the value of education helped sustain them through countless hardships. And ultimately, the dreams of Opal and Tonnie Springfield were realized through their grandchildren. More than just the story of one family in one small place, The Legacy of Tamar reflects similar struggles by African American families throughout the South and the nation. The Author: Raye Springfield lives in Nashville, Tennessee, where she is assistant general counsel for the Tennessee Board of Regents. She was previously an assistant attorney general for the State of Tennessee.
Magnetocapacitance without magnetoelectric coupling (2006)

The existence of a magnetodielectric (magnetocapacitance) effect is often used as a test for multiferroic behavior in new material systems. However, strong magnetodielectric effects can also be achieved through a combination of magnetoresistance and the Maxwell-Wagner effect, unrelated to true magnetoelectric coupling. The fact that this resistive magnetocapacitance does not require multiferroic materials may be advantageous for practical applications. Conversely, however, it also implies that magnetocapacitance per se is not sufficient to establish that a material is multiferroic.
In vivo human crystalline lens topography (2012)

Custom high-resolution high-speed anterior segment spectral domain optical coherence tomography (OCT) was used to characterize three-dimensionally (3-D) the human crystalline lens in vivo. The system was provided with custom algorithms for denoising and segmentation of the images, as well as for fan (scanning) and optical (refraction) distortion correction, to provide fully quantitative images of the anterior and posterior crystalline lens surfaces. The method was tested on an artificial eye with known surfaces geometry and on a human lens in vitro, and demonstrated on three human lenses in vivo. Not correcting for distortion overestimated the anterior lens radius by 25% and the posterior lens radius by more than 65%. In vivo lens surfaces were fitted by biconicoids and Zernike polynomials after distortion correction. The anterior lens radii of curvature ranged from 10.27 to 14.14 mm, and the posterior lens radii of curvature ranged from 6.12 to 7.54 mm. Surface asphericities ranged from -0.04 to -1.96. The lens surfaces were well fitted by quadrics (with variation smaller than 2%, for 5-mm pupils), with low amounts of high order terms. Surface lens astigmatism was significant, with the anterior lens typically showing horizontal astigmatism ([Formula: see text] ranging from -11 to -1 µm) and the posterior lens showing vertical astigmatism ([Formula: see text] ranging from 6 to 10 µm).
[Progress of research on protein composition and gene therapy of Fanconi anaemia - review]. (2004)

Fanconi anaemia (FA) is an autosomal recessive inherited disorder caused by defects in hematopoietic stem cells. The clinical manifestations of FA are diverse and complicated. FA cells display high hypersensitivity to agents which produce interstrand DNA cross-links such as mitomycin C (MMC) or diepoxybutane (DEB). At least eight complementation groups with defects in eight genes (FANCA, FANCB, FANCC, FANCD(1), FANCD(2), FANCE, FANCF and FANCG) have been identified by gene analysis. Six genes (corresponding to subtypes A, C, D(2), E, F and G) have been coloned, and the encoded FA proteins interact in a common cellular pathway - "FA Pathway", through which modulate DNA repair. The progress of research on FA molecular mechanism provides gene therapy of FA with theory basis. FA cells transduced with the use of retrovirus carring the normal FA gene cDNA manifestate phenotypic correction of hypersensitivity to DNA cross-linking agents, such as MMC. In this review the clinical manifestations and gene composition of FA, and the functions of encoded FA proteins were summarized. The hematopoietic stem cell transplantation and gene therapy for FA patients were discussed.
High-efficiency NO /SUB x/ and SO /SUB x/ removal by electron beam (1985)

Encouraging laboratory analysis and cost projections are reported by the Department of Energy, Tennessee Valley Authority, and Cottrell Environmental Sciences. These agencies constructed a pilot facility at the Shawnee Power Station, Paducah, Kentucky, to investigate the combination process of a spray dryer, E-beam, and fabric filter. An alternate design has been devised to first remove the SO2 by dry flue-gas-desulfurization and subsequently remove NO /SUB x/ with a downstream E-beam. Economics for this process are pertinent for retrofit as well as new applications.
Human interleukin‐4 receptor signaling requires sequences contained within two cytoplasmic regions (1993)

The signaling pathway used by the murine or human interleukin-4 receptor (hIL-4R) has not been elucidated so far. As an approach to mapping the cytoplasmic regions of the hIL-4R that are essential for mediating the biological response upon IL-4 binding we have cloned and expressed the wild-type hIL-4R and several cytoplasmic deletion mutants in the murine IL-3-dependent pro-B cell line BA/F3. Transfection of the wild-type hIL-4R conferred the ability on BA/F3 cells to proliferate in a dose-dependent way when treated with human IL-4. The analysis of six deletion mutants indicated that the signaling function of the hIL-4R depends on sequences within two discontinuous regions that are located between amino acid IIe233 and Ser365 and Thr462 and Ala580 of the intracytoplasmic domain. The deletion of either of these regions totally abrogated IL-4-inducible growth. The relevance of our data is discussed in relation to the results obtained from similar studies with other members of the hematopoietin receptor superfamily.
Illegitimate Fertility of Psychotic Women (1970)

Earlier studies on psychotic patients suggested that their illegitimate fertility was lower than expected on the basis of general population trends. The present findings were part of a study on marriage and fertility of women suffering from schizophrenia and affective disorders since the impact of community orientated psychiatry; 1300 women were selected from admissions to a London hospital during 1955–63 and followed up until August 1966. The proportion of total live births which were illegitimate was 19·1% among the schizophrenics, 7·5% among the affectives and 12·7% in the general population of London during 1961. The high illegitimate fertility of schizophrenics is probably related to their low probability of marriage; more births occurred before than after admission, especially among the older group of women suffering from affective disorders. Most of the births were the result of a serious relationship rather than casual promiscuity, and they were more frequent among Jamaican patients and patients with probable psychopathic personalities in both clinical groups. The genetic and social relevance of the study is discussed.
Extractive crystallization of salts from concentrated aqueous solution (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTExtractive crystallization of salts from concentrated aqueous solutionDavid A. Weingaertner, Scott Lynn, and Donald N. HansonCite this: Ind. Eng. Chem. Res. 1991, 30, 3, 490–501Publication Date (Print):March 1, 1991Publication History Published online1 May 2002Published inissue 1 March 1991https://pubs.acs.org/doi/10.1021/ie00051a009https://doi.org/10.1021/ie00051a009research-articleACS PublicationsRequest reuse permissionsArticle Views846Altmetric-Citations78LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Incorporation of deuterium-labelled analogs of isopentenyl diphosphate for the elucidation of the stereochemistry of rubber biosynthesis (2006)

A series of six deuterium-labelled analogs of isopententyl diphosphate (IPP) was prepared to investigate the detailed stereochemical course of addition of C5 units during rubber biosynthesis in Hevea brasiliensis and Parthenium argentatum. These analogs were incorporated into the cis-polyisoprene chain by rubber transferase in rubber particles, and the stereochemistry was determined by 2H-NMR analysis of the polymer or of levulinic acid derivatives obtained from its ozonolytic degradation. Results indicate that rubber chain elongation occurs with loss of the pro-S hydrogen of IPP, addition of the allylic diphosphate to the si face of IPP and inversion of stereochemistry at the carbon bearing the diphosphate.
Directed semlsynthetic point mutational analysis of an RNA polymerase III promoter (1983)

The transcription of tRNA and Alu repeat genes in vitro by RNA polymerase III has been shown to be dependent on the presence of two intragenic regions, which contain the consensus sequences RGYNNRRYGG (box A) and GA/TTCRANNC (box B), located 30-60 nucleotides apart. The role of box B and some of its variants was analyzed by a novel method involving the chemical synthesis of double stranded analogues of box B which were subsequently cloned into recombinant vectors carrying box A alone. This method creates a series of semi-synthetic RNA polymerase III promoters and has no limitation on the structure and number of variants which can be generated. The results showed the "wild type" sequence GTTCGAGAC and the sequence GTTCGTGAC (an A to T transversion of the 6th position) were active in promoting RNA polIII transcription. However, the box B sequences CTTCGAGAC and GTACGAGA, where the only departures from the consensus are a G to C and an A to T transversion in the 1st and 3rd positions respectively, were unable to restore promoter function.
Relationship between Calcium-Activated Chloride Channel 1 and MUC5AC in Goblet Cell Hyperplasia Induced by Interleukin-13 in Human Bronchial Epithelial Cells (2006)

IL-13 might induce the expression of MUC5AC and hCLCA1 gene and protein in well-differentiated NHBE cells. These cells might also differentiate into goblet cells and become hyperplastic.