gebhart/patrepeval huggingface dataset:
Long Interpolation of Audio Signals Using Linear Prediction in Sinusoidal Modeling (2005)

International audience
Ion source for electrohydrodynamic mass spectrometry (1995)

Abstract Early in the development of electrohydrodynamic mass spectrometry (EH‐MS), it was realized that ion source performance improved when the sample liquid was supplied discontinuously to the capillary emitter. Based on this realization, an ion source was designed that operates without an external sample supply system. Its essential part is a metal capillary that serves both as the liquid reservoir and the field anode and is mounted exchangeably on a pushrod. As the liquid flow is field induced, the flow rates are extremely low, in the range of 0.2 nl min −1 . Thus, in spite of high analyte concentrations needed, sample consumption is only a few picomoles per mass scan. Moreover, the emission of larger droplets is avoided, which contributes to the stability of the ion signal. As the capillary emitter is mounted on a standard emitter carrier known from field desorption (FD) MS, the new ion source is compatible with conventional FD ion sources. EH mass spectra of analytes could be obtained from substances whose solubility in glycerol was>0.5 mol l −1 . The substances investigated with the new ion source include sugars, amino acids, peptides and an antibiotic. The general characteristics of the mass spectra are essentially the same as those known from other EH ion sources. Besides abundant solvent cluster ions, only cationated or protonated molecules of the analytes could be detected, frequently with one or more solvent molecules attached to the ions. Fragment ions were not observed.
Full-waveform inversion using smoothing kernels (2016)

We introduce smoothing kernels into the FWI (full waveform inversion) objective function to mitigate the cycle skipping problem. This approach resembles the commonly used frequency continuation technique, wherein low frequencies are inverted for first, followed by progressively higher and higher frequencies. However, FWI with smoothing kernels does not require the existence of very low frequency components in seismic data. Its implementation is straightforward based on the conventional least-squares FWI. It successively minimizes a sequence of modified least-squares objective functions which measure smoothed data residuals. The smoothing strength at each stage of the inversion is different: it begins with strong smoothing and ends with no smoothing, at which point the inversion converges to the solution of the original (unsmoothed) problem. We propose three alternative optimization strategies for inverting for velocity models using smoothing kernels: successive smoothing relaxation, smoothing path continuation, and homotopy continuation. Numerical examples demonstrate that FWI using smoothing kernels can effectively overcome the cycle skipping problem, and is capable of producing highly accurate velocity models even in salt-affected environments and in the absence of ultra low frequencies. Presentation Date: Thursday, October 20, 2016 Start Time: 9:20:00 AM Location: 162/164 Presentation Type: ORAL
NLS-dependent nuclear localization of p120<i>ctn</i>is necessary to relieve Kaiso-mediated transcriptional repression (2004)

The Armadillo catenin p120(ctn) regulates cadherin adhesive strength at the plasma membrane and interacts with the novel BTB/POZ transcriptional repressor Kaiso in the nucleus. The dual localization of p120(ctn) at cell-cell junctions and in the nucleus suggests that its nucleocytoplasmic trafficking is tightly regulated. Here we report on the identification of a specific and highly basic nuclear localization signal (NLS) in p120(ctn). The functionality of the NLS was validated by its ability to direct the nuclear localization of a heterologous beta-galactosidase-GFP fusion protein. Mutating two key positively charged lysines to neutral alanines in the NLS of full-length p120(ctn) inhibited both p120(ctn) nuclear localization as well as the characteristic p120(ctn)-induced branching phenotype that correlates with increased cell migration. However, while these findings and others suggested that nuclear localization of p120(ctn) was crucial for the p120(ctn)-induced branching phenotype, we found that forced nuclear localization of both wild-type and NLS-mutated p120(ctn) did not induce branching. Recently, we also found that one role of p120(ctn) was to regulate Kaiso-mediated transcriptional repression. However, it remained unclear whether p120(ctn) sequestered Kaiso in the cytosol or directly inhibited Kaiso transcriptional activity in the nucleus. Using minimal promoter assays, we show here that the regulatory effect of p120(ctn) on Kaiso transcriptional activity requires the nuclear translocation of p120(ctn). Therefore, an intact NLS in p120(ctn) is requisite for its first identified regulatory role of the transcriptional repressor Kaiso.
Regulation of reclamation (2016)

Mining provides the building blocks for human development underpinning the need of metal and mineral products. The Mineral Conservation and Development Rule (MCDR) was reorganized in 1988 by incorporating provisions on submission of mining plans, reclamation and rehabilitation of land, restoration of flora and environmental protection. Although there are many similarities in the national and regional governments of Australia, Canada, the United Kingdom, Europe, Japan and the United States, there are also many differences in their ways of dealing with the specific aspects of mine closure and management thereafter. The General Mining Act of 1872 authorizes the prospecting and mining of economic minerals on federal public lands. In Sweden, the Environmental Code is the chief environmental statute, which aims mainly on ‘promoting a sustainable development’, ensuring the protection against different pollutions, environmental conservation, efficient management of land and water areas, natural resources and energy.
Effects of Extraction on Wettability and Gluability of Apitong (Dipterocarpus Grandiflorus Blanco) (1977)

Abstract An investigation was made of the effects of extraction and various chemicals applied on veneer surface on the wettability and gluing properties of apitong, Dipterocarpus grandiflorus Blanco, using urea formaldehyde resin. Wettability was determined by measuring contact angles with distilled water. It was found that extraction with methanol-benzene greatly improved the wettability and gluability of apitong veneer. Likewise, surface treatment with methanol-benzene significantly increased the wettability of the veneer as well as the dry and wet shear strengths of the resulting bond. Treatment with sodium hydroxide increased both wettability and dry shear, but decreased the wet shear strength of the bond. Acetone did not have a significant effect on both wettability and dry shear, but decreased wet shear strength. On the other hand, ether had adverse effects on the wettability and gluability of apitong veneer. A positive linear correlation was found between wettability and gluability of apitong veneer.
Nanocomplexes loaded with miR-128-3p for enhancing chemotherapy effect of colorectal cancer through dual-targeting silence the activity of PI3K/AKT and MEK/ERK pathway (2020)

Although microRNAs (miRNAs)-based cancer therapy strategies have been proved to be efficient and superior to chemotherapeutic agents in certain extent, the unstable properties of miRNAs significantly impaired the wide application. Therefore, how to safely deliver the miRNAs to the targeted site of action is the most pivotal step to achieve the ideal treatment effect. In the present work, the miR-128-3p, which is able of inducing chromosomal instability, was loaded into the nanocomplexes developed by the PEG-PDMAEMA (PDMAEMA-NP). By this way, the miR-128-3p was shielded from exposure to various degrading enzymes in bloodstream. Additionally, the PEGylation endowed the PDMAEMA-NP with long time of circulation as demonstrated <i>in vivo</i> by pharmacokinetics investigation. To target and deliver the miR-128-3p to the site of action, a tumor-homing peptide CPKSNNGVC, which specifically targets the monocarboxylate transporter 1 (MCT1), was decorated on the surface of PDMAEMA-NP. Both <i>in vitro</i> and <i>in vivo</i> experiments demonstrated that more efficient delivery of miR-128-3p to cells or tumor tissues was obtained by the PDMAEMA-NP than plasmid. Additionally, modification of C peptides further enhanced the tumor accumulation of miR-128-3p, and in turn contributed to the stronger tumor growth inhibition effect. Underlying mechanisms study revealed that the miR-128-3p inhibited the growth, migration, and invasion of colorectal cancer (CRC) cells and progress of CRC tissues through silence of the activity of PI3K/AKT and MEK/ERK pathway. By this way, the chemotherapy effect of 5-Fluorouracil (5-Fu) was dramatically improved after co-treating the cells with miR-128-3p formulations.
Ni-based Metal Matrix Composite Functionally Graded Coatings (2012)

Functional graded materials (FGMs) are a class of composites that have a continuous variation of material properties. One of the aims of such variation is to relieve the stress concentrations that appear in laminated materials. Coating techniques using powder as filler material can be adapted for the manufacture of composition gradients by means of a mixing unit in a powder feed system which is the basis of the laser cladding technology. The aim of this paper is to get coats with layers of the highest possible ceramic concentration on a metal matrix composite (MMC) with the help of the FGM methodology.
A new thin-film space PV module technology (2003)

ITN Energy Systems has developed a new thin-film space PV module technology based on copper indium gallium diselenide (CIGS) solar cells deposited on flexible 25 /spl mu/m. (1 mil.) stainless steel substrates. The cells are constructed into modules using a welded contact technology that acts as both the electrical and structural interconnection between cells; Thus, the cell string does not require a supporting substrate. Coatings are applied to increase the emissivity and lower the on-orbit operating temperature. An electro-static discharge (ESD) layer is also applied for charge dissipation to mitigate interaction with the space environment. Preliminary thermal cycle test data indicates the technology is robust relative to the space environment.
Sensor-Based Identification of Opportune Moments for Triggering Notifications (2014)

Today's smartphones will issue a notification immediately after an event occurs, repeating unanswered notifications in fixed time intervals. The disadvantage of this issue-and-repeat strategy is that notifications can appear in inconvenient situations and thus are perceived as annoying and interrupting. The authors study the mobile context as inferred through a phone's sensors for both answered and ignored notifications. They conducted a large-scale, longitudinal study via the Google Play store and observed 6,581 notifications from 79 different users over 76 days. Their derived model can predict opportune moments to issue notifications with approximately 77 percent accuracy. Their findings could lead to intelligent strategies to issue unobtrusive notifications on today's smartphones at no extra cost. This article is part of a special issue on managing attention.
Biochemistry and Molecular Biology of Gelatinase B or Matrix Metalloproteinase-9 (MMP-9) (2002)

The matrix metalloproteinases (MMPs) form an enzyme family of which gelatinase B (MMP-9) represents the largest and most complex member. We focus here on the biochemical properties, regulation, and functions of gelatinase B. The tight regulation of gelatinase B activity is highly complex and is established at five different levels. The transcription of the gelatinase B-gene depends on various cis-elements in its gene promotor and is induced or repressed by a large variety of soluble factors, including cytokines, growth factors, and hormones and by cellular contacts acting through specific signaling pathways. The specific regulation of its secretion occurs in cells storing gelatinase B in granules. After secretion, progelatinase B must be activated through an activation network. The enzyme activity is further regulated by inhibition and by other mechanisms, such as fine-tuning and stabilization by glycosylation. The ability of gelatinase B to degrade components of the extracellular matrix and to regulate the activity of a number of soluble proteins confers an important role in various physiological and pathological processes. These include reproduction, growth, development, inflammation, and vascular and proliferative diseases.
Hardware Accelerator to Detect Multi-Segment Virus Patterns (2014)

Multi-segment pattern is a common virus structure, and there are 2229 multi-segment patterns in the ClamAV virus database version 54. We observe that (i) the pattern set contains over 100 nondistinctive short segments, e.g. 2 bytes of zero; (ii) some of the 2-byte segments can appear many times in one or more patterns; (iii) some patterns contain a large number of 2-byte segments; (iv) many short segments are substrings/suffixes of other longer segments; and (v) adjacent segments may contain overlapping bytes. The aforementioned properties pose great difficulties to the conventional detection methods. Instead of viewing the virus signature as a byte sequence, we regard the pattern to be composed of a sequence of tokens, where each token corresponds to a segment. We transform the input byte stream into a token stream. The detection engine will then process the token stream to determine if any virus signatures can be found. Our detection method for the 2229 multi-segment patterns can be implemented on a field programmable gate array (FPGA) using 290KB on-chip memory. The device can operate at 170MHz and it can process 1 byte per cycle. The processing architecture is memory based. When the pattern set is updated, the FPGA need not be reconfigured.
Cathepsin K and the Design of Inhibitors of Cathepsin K (2000)

Cathepsin K, a cysteine protease of the papain family, was identified by sequencing complementary DNA libraries derived from osteoclasts. Cathepsin K can cleave bone proteins such as Type I collagen, osteopontin, and osteonectin. The localization and maturation of cathepsin K in activated osteoclasts have been characterized. Furthermore, mutation of the gene expressing cathepsin K in humans results in pycnodysostosis, an autosomal recessive condition, resulting in osteoprosis and increased bone fragility. Knockout of cathepsin K in the mouse also results in retarded bone matrix degradation and osteopetrosis. Together, these data demonstrate that inhibition of cathepsin K should result in a dimunition of osteoclast-mediated bone resorption. Several novel classes of cathepsin K inhibitors have been designed from X-ray co-crystal structures of peptide aldehydes bound to papain. The convergence of the design of novel inhibitors and the discovery of cathepsin K has created opportunities to further understand bone and cartilage biology as well as provide new therapeutic agents for the treatment of disease states in man such as osteoporosis.
Human Immune Response to Proteins of Cytomegalovirus (1980)

A detergent extract of 35S-methionine-labeled cytomegalovirus(CMV)-infected cells was analyzed by crossed-immunoelectrophoresis using human sera with high anti-CMV antibody titers. Six distinct precipitation lines could be seen in agarose gels after crossed-immunoelectrophoresis. On further analysis of the precipitation lines using SDS-PAGE, the proteins obtained could be related to proteins identical in size, obtained from purified CMV nucleocapsids.
An Optimization Based Integrated Short-Term Refined Petroleum Product Planning System (1987)

This paper contains a new and very successful application of mathematical programming in the petroleum industry. Specifically, the paper describes the design and implementation of a model and computer system to address the complex short-term planning and operational issues associated with the supply, distribution, and marketing of refined petroleum products. This system has been successfully implemented at Citgo Petroleum Corporation. The benefits include a $116 million reduction (based on historical inventory-to-sales ratios) in product inventories resulting in a $14 million per year reduction in working capital costs and an additional $2.5 million per year estimated contribution to bottom line profits due to multiple supply, distribution, and marketing insights provided by the system.
Improvement of Vitamin D Status via Daily Intake of Fortified Yogurt Drink Either with or without Extra Calcium Ameliorates Systemic Inflammatory Biomarkers, including Adipokines, in the Subjects with Type 2 Diabetes (2012)

Daily intake of vitamin D-fortified doogh improved inflammatory markers in T2D subjects, and extra calcium conferred additional benefit only for the antiinflammatory adipokine, i.e. adiponectin.
Total synthesis of amphoteronolide B and amphotericin B. 1. Strategy and stereocontrolled construction of key building blocks (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal synthesis of amphoteronolide B and amphotericin B. 1. Strategy and stereocontrolled construction of key building blocksKyriacos C. Nicolaou, R. A. Daines, J. Uenishi, W. S. Li, D. P. Papahatjis, and T. K. ChakrabortyCite this: J. Am. Chem. Soc. 1988, 110, 14, 4672–4685Publication Date (Print):July 1, 1988Publication History Published online1 May 2002Published inissue 1 July 1988https://doi.org/10.1021/ja00222a028RIGHTS & PERMISSIONSArticle Views2212Altmetric-Citations105LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Get e-Alerts Get e-Alerts
A 10 Gb/s 45 mW Adaptive 60 GHz Baseband in 65 nm CMOS (2012)

This paper presents a low-power mixed-signal adaptive 60 GHz baseband in 65 nm CMOS. The design integrates variable gain amplifiers, analog phase rotator, 40-coefficient I/Q decision feedback equalizers (DFEs), clock generation and data recovery circuits, and adaptation hardware. The baseband achieves 10 Gb/s operation with BER <; 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-12</sup> while consuming 53 mW (adaptation on)/45 mW (adaptation off), of which the core signal processing circuits consume only 29 mW.
Systems Competition and Network Effects (1994)

This paper discusses firm behavior, market performance, and the public and private institutions that arise in systems markets, i.e., markets where consumers use compatible components together to generate benefits. In such markets, which include communications networks and ‘hardware/software’ networks, popular products are inherently more valuable. These ‘network effects’ can drive corporate strategies and are critical in understanding innovation in many high-technology markets. The discussion here emphasizes the dynamics of consumer adoption decisions in the presence of network effects, competition between incompatible systems, and how suppliers choose which components are compatible and which are not.
Ototoxicity (1993)

No AccessAmerican Journal of AudiologyEdge Report1 Mar 1993OtotoxicityCurrent Issues Kathleen C. M. CampbellPhD Kathleen C. M. Campbell Division of Otolaryngology, SIU School of Medicine, P.O. Box 19230, 301 North Eighth Street, Springfield, IL 62794-9230 Google Scholar More articles by this author https://doi.org/10.1044/1059-0889.0201.15 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationTrack Citations ShareFacebookTwitterLinked In "Ototoxicity." American Journal of Audiology, 2(1), pp. 15–16 References Brown, D. R., Watchko, J. F., & Sabo, D. (1991). Neonatal sensorineural hearing loss associated with furosemide: a case-control study.Developmental Medicine and Child Neurology, 33, 816–823. Google Scholar Brummett, R. E., Fox, K. E., Jacobs, F., Kempton, J. B., Stokes, Z., & Richmond, A. B. (1990). Augmented gentamicin ototoxicity induced by vancomycin in guinea pigs.Archives of Otolaryngology–Head and Neck Surgery, 116, 61–64. Google Scholar Dodson, H. C., Bannister, L. H., & Douek, E. E. (1982). The effects of combined gentamicin and white noise on the spiral organ of young guinea pigs.Acta Otolaryngologica, 94, 193–202. Google Scholar Gregorio, M. W. (1991). Cisplatin chemoprotection and rescue: pharmacologic modulation of toxicity.Seminars in Oncology, 18(1), Suppl 3, 49–55. Google Scholar Meyerhoff, W. L., Maale, G. E., Yellin, W., & Roland, P. S. (1989). Audiologic threshold monitoring of patients receiving ototoxic drugs.Annals of Otology, Rhinology, and Laryngology, 98, 950–954. Google Scholar Rybak, L. P. (1992). Hearing: the effects of chemicals.Otolaryngology–Head and Neck Surgery, 106(6), 677–686. Google Scholar Uziel, A. (1985). Nongenetic factors affecting hearing development.Acta Otolaryngologica, Suppl 421: 57–61. Google Scholar Additional Resources FiguresReferencesRelatedDetails Volume 2Issue 1March 1993Pages: 15-16 Get Permissions Add to your Mendeley library History Published in issue: Mar 1, 1993 Metrics Downloaded 62 times Topicsasha-topicsleader-topicsasha-article-typesKeywordshearing lossaminoglycosideschemotherapeutic agentsOtotoxicityloop diureticsCopyright & PermissionsCopyright © 1993 American Speech-Language-Hearing AssociationPDF DownloadLoading ...
Molecular Determinants for Modulation of Persistent Sodium Current by G-Protein βγ Subunits (2005)

Voltage-gated sodium channels are responsible for the upstroke of the action potential in most excitable cells, and their fast inactivation is essential for controlling electrical signaling. In addition, a noninactivating, persistent component of sodium current, I(NaP), has been implicated in integrative functions of neurons including threshold for firing, neuronal bursting, and signal integration. G-protein betagamma subunits increase I(NaP), but the sodium channel subtypes that conduct I(NaP) and the target site(s) on the sodium channel molecule required for modulation by Gbetagamma are poorly defined. Here, we show that I(NaP) conducted by Na(v)1.1 and Na(v)1.2 channels (Na(v)1.1 > Na(v)1.2) is modulated by Gbetagamma; Na(v)1.4 and Na(v)1.5 channels produce smaller I(NaP) that is not regulated by Gbetagamma. These qualitative differences in modulation by Gbetagamma are determined by the transmembrane body of the sodium channels rather than their cytoplasmic C-terminal domains, which have been implicated previously in modulation by Gbetagamma. However, the C-terminal domains determine the quantitative extent of modulation of Na(v)1.2 channels by Gbetagamma. Studies of chimeric and truncated Na(v)1.2 channels identify molecular determinants that affect modulation of I(NaP) located between amino acid residue 1890 and the C terminus at residue 2005. The last 28 amino acid residues of the C terminus are sufficient to support modulation by Gbetagamma when attached to the proximal C-terminal domain. Our results further define the sodium channel subtypes that generate I(NaP) and identify crucial molecular determinants in the C-terminal domain required for modulation by Gbetagamma when attached to the transmembrane body of a responsive sodium channel.