gebhart/patrepeval huggingface dataset:
Hearing and glycoconjugates: localization of Le<sup>y</sup>, Le<sup>x</sup> and sialosyl-Le<sup>x</sup> in guinea pig cochlea, particularly at the tectorial membrane and sensory epithelia of the organ of Corti (1993)

Immunohistological examination of guinea pig cochleas was performed using a panel of 25 monoclonal antibodies directed to various lacto-, ganglio- and globo-series carbohydrate epitopes as well as mucin-type epitopes. Lacto-series structures were found to be localized at specific sites of the tectorial membrane (TM) and Corti's organ, i.e. alpha 1-->3 fucosyl type 2 chain (Le(x)) at Kimura's membrane, marginal band and covering net of TM; alpha 1-->2, alpha 1-->3 difucosyl type 2 chain (Le(y)) at covering net; and sialosyl-Le(x) and sialosyl-i at Kimura's membrane and sensory epithelia, particularly sensory tips of hair cells of Corti's organ. In striking contrast, ganglio-series structures (GM3, GD3, GD2, 9-O-Ac-GD3) were detected at spiral ganglion cells, neuronal fibres and stria vascularis, but were completely absent from Corti's organ and most of the TM. Other epitope structures defined by various antibodies were not detectable at any location. The functional roles of lacto-series carbohydrate epitopes expressed at TM and Corti's organ remain unknown. However, the expression of Le(y) (but not other structures) in association with developmental deficiency of TM induced by 6-N-propyl-2-thiouracil in rats suggests that Le(y) plays some role in normal TM development. The presence of Le(x) at Kimura's membrane and sialosyl-Le(x) at hair cell sensory tips of Corti's organ suggests the intriguing possibility that these fucosylated/sialosylated carbohydrate structures play some role in interactions (either attractive or repulsive) of these inner ear components, which have been implicated in the physiology of hearing, i.e. the conversion of sound waves to nerve impulses.
Zstandard Compression and the application/zstd Media Type (2018)

Zstandard, or zstd (pronounced zee standard), is a data
compression mechanism. This document describes the mechanism, and
registers a media type and content encoding to be used when
transporting zstd-compressed content via Multipurpose Internet Mail
Extensions (MIME). Despite use of the word standard as part of its
name, readers are advised that this document is not an Internet
Standards Track specification, and is being published for
informational purposes only.
Procesos migratorios contemporáneos (2014)

To finish the year 2013 with a number of the magazine Society and Equity dedicated to the issue of migration is in no case an insignificant fact. Just a  few months ago we commemorated 40 years since the coup that sparked the largest migration of our Chilean history: exile.
Two-Layer Coded Spatial Modulation With Block Markov Superposition Transmission (2015)

This paper is concerned with the spatial modulation (SM), a multiple-input multiple-output (MIMO) transmission technique, that maps information bits not only into the conventional two-dimensional signal points but also into the indices of active transmit antennas. We present a two-layer coded SM scheme, in which the spatial bits carried by the antenna indices and the signal bits carried by the conventional signals are protected separately by two error correction codes. For the ease of decoding process, the code rates are allocated according to the chain rule of the mutual information. We choose block Markov superposition transmission (BMST) codes for each layer, since they are easily designed for any given code rate with a predictable performance lower bound. An iterative sliding-window decoding algorithm is also presented by exchanging messages iteratively between the two BMST decoders and the soft-in soft-out (SISO) demapper of the SM. To reduce the computational complexity, we propose to implement the SISO demapping algorithm by employing only partial soft inputs. Numerical results show that the BMST-SM system performs well over uncorrelated Rayleigh fading channels.
The role of factor XIII in fibroblast proliferation (1979)

The role of factor XIII in fibroblast growth was investigated by means of 3T6 cell culture on fibrin plates prepared from purified fibrinogen and factor XIII concentrate in the presence of various concentrations of the factor XIII inhibitor, glycine ethyl ester (GEE). Electrophoretic analysis of the reduced fibrin preparations indicated that γ-chains were almost exhaustively dimerized in 2 hours regardless of the inhibitor and α-chain crosslinking ceased in about 6 hours. 1-5 mM GEE failed to inhibit γ-γcrosslinking but did inhibit α-polimerization depending on the concentration. 3×104 living cells were seeded in Dulbecco-Vogt-Modified Eagles medium supplemented with 10% heat-inactivated fetal calf serum on a fibrin plate 3 hours after its clotting in the culture bottle and the cell growth rate was determined from the living cells count after cultivation for 48 hours.The cells were poorly proliferated on fibrin prepared in the presence of the inhibitor, but grew well on fibrin without the inhibitor and even with the inhibitors added at 3 hours after fibrin clotting. The cell growth rate was proportional to the decrease in α-chain content, i. e. the densitometrically determined α/β for the electrophoretic pattern. Thus 3T6 fibroblast proliferation appeared to depend essentially on the extent of α-chain crosslinking of its supporting fibrin matrix after the completing of γ-γ crosslinking.
A Convex Regularize for Reducing Color Artifact in Color Image Recovery (2013)

We propose a new convex regularizer, named the local color nuclear norm (LCNN), for color image recovery. The LCNN is designed to promote a property inherent in natural color images - in which their local color distributions often exhibit strong linearity - and is thus expected to reduce color artifact effectively. In addition, the very nature of LCNN allows us to incorporate it into various types of color image recovery formulations, with the associated convex optimization problems solvable using proximal splitting techniques. Applications of LCNN are demonstrated with illustrative numerical examples.
Lithiation of N,N-dimethylmethallylamine (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLithiation of N,N-dimethylmethallylamineJohn J. Fitt and Heinz W. GschwendCite this: J. Org. Chem. 1981, 46, 16, 3349–3352Publication Date (Print):July 1, 1981Publication History Published online1 May 2002Published inissue 1 July 1981https://pubs.acs.org/doi/10.1021/jo00329a046https://doi.org/10.1021/jo00329a046research-articleACS PublicationsRequest reuse permissionsArticle Views170Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Studies on canola seed in turkey grower diet: Effects on ω-3 fatty acid composition of breast meat, breast skin and selected organs (1993)

The use of full-fat canola seed as a source of ω-3 fatty acids in rations for turkeys was assessed in 12-wk-old Nicholas heavy broiler turkeys of both sexes. Results indicate that dietary C 18:3ω3 from full-fat canola seed is readily absorbed and converted to its longer chain metabolites (C 20:5ω3 , C 22:5ω3 , and C 22:6ω3 ) prior to tissue deposition. Key words: Canola, turkeys, ω-3 fatty acids
Regulatory T Cells Dampen Pulmonary Inflammation and Lung Injury in an Animal Model of <i>Pneumocystis</i> Pneumonia (2006)

CD4+CD25+FoxP3+ regulatory T cells are decreased in patients infected with HIV and have been shown to be critical in mediating Ag tolerance in the lung. Because a subset of Pneumocystis-infected individuals develop substantial lung injury, which can be modeled in immune reconstituted scid mice, we used mouse models of Pneumocystis carinii to investigate the role of regulatory T cells in opportunistic infection and immune reconstitution. In this study, we show that CD4+CD25+FoxP3+ cells are part of the host response to Pneumocystis in CD4+ T cell-intact mice. Moreover, lung injury and proinflammatory Th1 and Th2 cytokine levels in the bronchoalveolar lavage fluid and lung homogenate were increased following CD4+CD25- immune reconstitution in Pneumocystis-infected SCID mice but not in CD4+CD25+ T cell-reconstituted animals. The ability of CD4+CD25+ T cells to control inflammation and injury during the course of Pneumocystis was confirmed by treatment of wild-type C57BL/6 mice with anti-CD25 mAb. These data show that CD4+CD25+ T cells control pulmonary inflammation and lung injury associated with Pneumocystis infection both in the setting of immune reconstitution as well as new acquisition of infection.
Prospects for the Uruguay Round in Agriculture (2019)

The Uruguay Round of Multilateral Trade Negotiations is scheduled to conclude in December 1990. This chapter argues that a “framework agreement” in agriculture will emerge, which closely resembles the conception put forward in the proposals of the US and Cairns Group. In the latter part of 1989, the US put forward its final proposal for agriculture in General Agreement on Tariffs and Trade (GATT). Stefan Tangermann argues that the European Community’s loss on the GATT oilseeds panel strengthens the internal case in the Community for converting to tariffication in the particular sector as an alternative to current price supports. Many commodity groups, and their elected representatives in Congress, seem unable to decide if GATT is an ineffectual group of diplomatic Dr. Jekylls, or a threat to farmers, capable of becoming a monstrous Mr. Hyde. The domestic farm legislation passed in 1990 will contain changes that support the US position in GATT.
PROTECTION AGAINST LETHAL ORGANOPHOSPHATE POISONING BY QUATERNARY PYRIDINE ALDOXIMES (1959)

The effect of 18 pyridinium aldoximes on diethylphosphoryl-acetocholinesterase in vitro and the protection against lethal poisoning by ethyl pyrophosphate (TEPP) in mice pretreated with 0.095 m.mole/kg. of these oximes was investigated. Monoximes and dioximes of polymethylenebispyridinium compounds were studied in greater detail since they were up to 22 times more potent than pyridine-2-aldoxime methiodide (2-hydroxyiminomethyl-N-methylpyridinium iodide) in reactivating diethylphosphoryl-acetocholinesterase in vitro and protected mice against lethal poisoning by up to 15 LD100 of ethyl pyrophosphate. These oximes were also up to 52 times more potent than pyridine-2-aldoxime methiodide in reactivating di-isopropylphosphoryl-acetocholinesterase in vitro and were effective in preventing lethal poisoning by dyflos (di-isopropyl phosphorofluoridate). The antidotal action against diethyl phosphostigmine (Ro 3-0340) was even greater than that against ethyl pyrophosphate. Some of the most effective oximes had antidotal actions in poisoning by ethyl pyrophosphate, diethyl phosphostigmine and dyflos when given in 0.0095 m.mole/kg. and this effect was enhanced by 1 mg./kg. atropine sulphate. In vivo reactivation of diethylphosphoryl-acetocholinesterases by 0.0095 or 0.095 m.mole/kg. of oximes of polymethylenebispyridinium compounds was demonstrated in blood but not in brain. Atropine-like and neuromuscular blocking activities were studied on isolated organs and protection against lethal doses of neostigmine and related anticholinesterases were also investigated. Some of the oximes of polymethylenebispyridinium compounds have, relative to pyridine-2-aldoxime methiodide, a higher therapeutic ratio in mice and considerably greater water-solubility. The possible advantages to be gained from their use in preference to pyridine-2-aldoxime methiodide are discussed.
Unusual Intracellular Accumulation of S-Adenosyl-L-methionine by Microorganisms (1984)

In survey studies on microbial accumulation of S-adenosyl-L-methionine (AdoMet), various yeasts were found to accumulate AdoMet intracellularly to a high concentration when they were grown in medium containing L-methionine. A group of sake yeasts (Saccharomyces sake) exhibited especially high accumulation. Of these yeasts, S. sake Kyokai No. 6 (K-6), which exhibited the highest accumulation, produced 12.6μmiol (5.03 mg) of AdoMet/ml broth. Almost all AdoMet produced was accumulated in cells, extracellular accumulation of AdoMet being very low. The maximum content of AdoMet of cells was 5.31μmiol (205mg)/g dry cells. This was the highest value that had been reported. Methionine adenosyltransferase (EC 2.5.1.6) activity was significantly higher in this yeast compared to those in other yeasts tested. Ultraviolet photomicrographic studies on S. sakeK-6 suggested that AdoMet was gradually accumulated in vacuoles with the passage of cultivation time.
T: A Multithreaded Massively Parallel Architecture (2005)

What should the architecture of each node in a general purpose, massively parallel architecture (MPA) be? We frame the question in concrete terms by describing two fundamental problems that must be solved well in any general purpose MPA. From this, we systematically develop the required logical organization of an MPA node, and present some details of *T (pronounced Start), a concrete architecture designed to these requirements. *T is a direct descendant of dynamic dataflow architectures, and unifies them with von Neumann architectures. We discuss a hand-compiled example and some compilation issues.
Combination of thermal extrusion printing and ultrafast laser fabrication for the manufacturing of 3D composite scaffolds (2014)

We present a novel approach to manufacturing 3D microstructured composite scaffolds for tissue engineering applications. A thermal extrusion 3D printer – a simple, low-cost tabletop device enabling rapid materialization of CAD models in plastics – was used to produce cm-scale microporous scaffolds out of polylactic acid (PLA). The fabricated objects were subsequently immersed in a photosensitive monomer solution and direct laser writing technique (DLW) was used to refine its inner structure by fabricating a fine mesh inside the previously produced scaffold. In addition, a composite material structure out of four different materials fabricated via DLW is presented. This technique, empowered by ultrafast lasers allows 3D structuring with high spatial resolution in a great variety of photosensitive materials. A composite scaffold made of distinct materials and periodicities is acquired after the development process used to wash out non-linked monomers. Another way to modify the 3D printed PLA surfaces was also demonstrated - ablation with femtosecond laser beam. Structure geometry on macro- to micro- scales could be finely tuned by combining these fabrication techniques. Such artificial 3D substrates could be used for cell growth or as biocompatible-biodegradable implants. To our best knowledge, this is the first experimental demonstration showing the creation of composite 3D scaffolds using convenient 3D printing combined with DLW. This combination of distinct material processing techniques enables rapid fabrication of diverse functional micro-featured and integrated devices. Hopefully, the proposed approach will find numerous applications in the field of tissue engineering, as well as in microelectromechanical systems, microfluidics, microoptics and others.
[Case of systolic anterior motion of mitral valve after mitral valve repair]. (2004)

A 56-year-old woman was underwent mitral valve repair for prolapse of the posterior mitral leaflet. Intraoperative transesophageal echocardiography (TEE) showed systolic anterior motion (SAM) of the mitral valve at the weaning from cardiopulmonary bypass (CPB). Sliding technique was easily performed at the second pump run. Intraoperative TEE demonstrated no SAM or residual mitral regurgitation after the second pump run.
Expression of Hemin Receptor Molecule ChuA Is Influenced by RfaH in Uropathogenic <i>Escherichia coli</i> Strain 536 (2001)

The outer membrane protein ChuA responsible for hemin utilization has been recently identified in several pathogenic Escherichia coli strains. We report that the regulatory protein RfaH influences ChuA expression in the uropathogenic E. coli strain 536. In an rfaH mutant, the chuA transcript as well as the ChuA protein levels were significantly decreased in comparison with those in the wild-type strain. Within the chuA gene, a consensus motif known as the JUMPStart (just upstream of many polysaccharide associated gene starts) sequence was found, which is shared by RfaH-affected operons. Furthermore, the presence of two different subclasses of the chuA determinant and their distribution in E. coli pathogroups are described.
Generating highly interactive user interfaces (1989)

Developers of User Interface Management Systems (UIMS) have demonstrated that separating the application from its user interface supports device independence and customization. Interfaces produced in UIMS are typically crafted by designers expert in human factors and graphic arts. Little attention has been paid, however, to capturing the knowledge of such experts so that interfaces might be automatically generated by the application of style rules to additional applications. This paper considers how toolkits and style rules can be structured so that the resulting interfaces take advantage of the best human factors and graphic arts knowledge, and are consistently styled.
SSLNP: Secure Service Level Negotiation Protocol (2009)

Today, the emerging new services like Voice over IP (VoIP) and Video on Demand (VoD) require Quality of Service (QoS) guarantee. These services can be accessed using wireless technologies such as Wi-Fi or WiMax which may make the concerned communications vulnerable to security attacks because of the open medium on which these access technologies are based. Thus, security level must also be guaranteed. In this paper, we present a protocol for dynamic negotiation of a service level covering QoS and security. Then, we provide its negotiation flow with security features using WSS, SSL and IPSec. Since, these security protocols may have an impact on the negotiation protocol performances; we will also evaluate this impact. Test results and implementation aspects are also shown in this paper.
Plasmid-encoded NP73-102 modulates atrial natriuretic peptide receptor signaling and plays a critical role in inducing tolerogenic dendritic cells (2011)

Modulation of NPRA signaling in DCs leads to immune tolerance and TLR2 and SOCS3 are involved in this induction.
The Effect of Locally Delivered Doxycycline in the Treatment of Chronic Periodontitis. A Clinical and Microbiological Cohort Study (2010)

Both treatment modalities provided comparable clinical and microbiological results in the treatment of chronic periodontitis.
Development of Receptors for Insulin and Insulin-Like Growth Factor-I in Head and Brain of Chick Embryos: Autoradiographic Localization* (1989)

In whole brain of chick embryos insulin receptors are highest at the end of embryonic development, while insulin-like growth factor-I (IGF-I) receptors dominate in the early stages. These studies provided evidence for developmental regulation of both types of receptors, but they did not provide information on possible differences between brain regions at each developmental stage or within one region at different embryonic ages. We have now localized the specific binding of [125I]insulin and [125I]IGF-I in sections of head and brain using autoradiography and computer-assisted densitometric analysis. Embryos have been studied from the latter part of organogenesis (days 6 and 12) through late development (day 18, i.e. 3 days before hatching), and the binding patterns have been compared with those in the adult brain. At all ages the binding of both ligands was to discrete anatomical regions. Interestingly, while in late embryos and adult brain the patterns of [125I]insulin and [125I] IGF-I binding were quite distinct, in young embryos both ligands showed very similar localization of binding. In young embryos the retina and lateral wall of the growing encephalic vesicles had the highest binding of both [125I]insulin and [125I]IGF-I. In older embryos, as in the adult brain, insulin binding was high in the paleostriatum augmentatum and molecular layer of the cerebellum, while IGF-I binding was prominent in the hippocampus and neostriatum. The mapping of receptors in a vertebrate embryo model from early prenatal development until adulthood predicts great overlap in any possible function of insulin and IGF-I in brain development, while it anticipates differential localized actions of the peptides in the mature brain.
Novel Peptide-Heterocycle Hybrids: Synthesis and Preliminary Studies on Calpain Inhibition (2002)

New peptidic compounds, having peptide chains linked to bi- and tricyclic heterocycles (peptide-heterocycle hybrids), have been synthesized. The heterocyclic components are derivatives of partially reduced isoquinoline and pyrido[1,2-b]isoquinoline bearing α,β-unsaturated carbonyl functionalities. The heterocyclic compounds have been used as acylating agents in coupling reactions with short N-unprotected peptides. Based on our interest on potential calpain inhibitors, we have used short (2–4 amino acids) peptides with hydrophobic amino acids of the two enantiomeric series. We report preliminary studies on the inhibition of calpain, with some compounds having IC50 values in the nanomolar range.
Large-conductance voltage- and Ca<sup>2+</sup>-activated K<sup>+</sup>channels regulate human detrusor smooth muscle function (2011)

The large-conductance voltage- and Ca(2+)-activated K(+) (BK) channel is expressed in many smooth muscle types, but its role in human detrusor smooth muscle (DSM) is unclear. With a multidisciplinary approach spanning channel molecules, single-channel activity, freshly isolated human DSM cells, intact DSM preparations, and the BK channel specific inhibitor iberiotoxin, we elucidated human DSM BK channel function and regulation. Native human DSM tissues were obtained during open surgeries from patients with no preoperative history of overactive bladder. RT-PCR experiments on single human DSM cells showed mRNA expression of BK channel α-, β(1)-, and β(4)-subunits. Western blot and immunocytochemistry confirmed BK channel α, β(1), and β(4) protein expression. Native human BK channel properties were described using the perforated whole cell configuration of the patch-clamp technique. In freshly isolated human DSM cells, BK channel blockade with iberiotoxin inhibited a significant portion of the total voltage step-induced whole cell K(+) current. From single BK channel recordings, human BK channel conductance was calculated to be 136 pS. Voltage-dependent iberiotoxin- and ryanodine-sensitive transient BK currents were identified in human DSM cells. In current-clamp mode, iberiotoxin inhibited the hyperpolarizing membrane potential transients and depolarized the cell resting membrane potential. Isometric DSM tension recordings revealed that BK channels principally control the contractions of isolated human DSM strips. Collectively, our results indicate that BK channels are fundamental regulators of DSM excitability and contractility and may represent new targets for pharmacological or genetic control of urinary bladder function in humans.