gebhart/patrepeval huggingface dataset:
Human DESC1 serine protease confers tumorigenic properties to MDCK cells and it is upregulated in tumours of different origin (2007)

Proteolysis of the extracellular matrix components plays a crucial role in the regulation of the cellular and physiological processes, and different pathologies have been associated with the loss or gain of function of proteolytic enzymes. DESC1 (differentially expressed in squamous cell carcinoma gene 1), a member of the TTSP (type II transmembrane serine protease) family of serine proteases, is an epithelial-specific enzyme that has been found downregulated in squamous cell carcinoma of the head and neck region. We describe new properties of DESC1 suggesting that this protease may be involved in the progression of some type of tumours. Thus, this enzyme hydrolyses some extracellular matrix components, such as fibronectin, gelatin or fibrinogen. Moreover, Madin-Darby canine kidney (MDCK) cells expressing exogenous human DESC1 acquire properties associated with tumour growth such as enhanced motility and an increase of tubular forms in a 3D collagen lattice following HGF treatment. Finally, we generated polyclonal anti-DESC1 antibodies and immunohistochemical analysis in tissues different from head and neck region indicated that this protease was overexpressed in tumours of diverse origins. Taken together, our results suggest that DESC1 could be considered as a potential therapeutic target in some type of tumours.
Virtues of Volatility: A Facile Transesterification Approach to Boronic Acids (2019)

Boronic acids are an increasingly important compound class for many applications, including C–C bond formation reactions, medicinal chemistry, and diagnostics. The deprotection of boronic ester intermediates is frequently a problematic and inefficient step in boronic acid syntheses. We describe an approach that highly facilitates this transformation by leveraging the volatility of methylboronic acid and its diol esters. The method is performed under mild conditions, provides high yields, and eliminates cumbersome and problematic purification steps.
Reversibler dielektrischer Durchbruch von Zellmembranen in elektrostatischen Feldern / Reversible Dielectric Breakdown of Cell Membranes by Electrostatic Fields (1974)

Article Reversibler dielektrischer Durchbruch von Zellmembranen in elektrostatischen Feldern / Reversible Dielectric Breakdown of Cell Membranes by Electrostatic Fields was published on June 1, 1974 in the journal Zeitschrift für Naturforschung C (volume 29, issue 5-6).
Carrier-Induced, Hapten-Specific Suppression: A Problem of Antigen Presentation? (1998)

Prior immunity against a carrier protein has been shown to modulate the serologic response to injected haptens attached to the same carrier. In particular, a carrier/hapten-carrier immunization protocol induces marked suppression for IgG2a anti-hapten Ab production but does not interfere with anti-carrier Ab responses. Although the phenomenon of epitopic suppression has been amply demonstrated, the mechanism underlying the suppression remains unknown. The selective deficiency in IgG2a secretion suggests that IFN-gamma-producing Th1 cells are not properly activated. We and others have shown that the nature of the APCs present during the first encounter with the Ag influences the development of selected Th populations in vivo; dendritic cells (DCs) seem to be required for the induction of primary, Th1-type responses. Since carrier priming induces the clonal expansion of specific B cells that appear to efficiently capture the Ag, we hypothesized that the hapten-carrier conjugate may be presented by B cells in preimmunized animals. Therefore, we immunized mice to the conjugate by injecting syngeneic DCs pulsed in vitro with the Ag. Our data show that an injection of DCs and IL-12 prevents epitopic suppression, suggesting that it may result from defective Ag presentation.
Dental services for people with learning disabilities (2013)

Jessica Shield and colleagues describe how the development of dental passports and reasonable adjustments by staff ensure service users receive a high standard of care
Cellular Interactions with Extracellular Matrix During Development and in Muscle Disease (2002)

The formation and maintenance of tissues in multicellular animals are crucially dependent on cellular interactions with the extracellular matrix (ECM). Two different studies on such interactions are presented herein. Studies on expression of laminins in normal and dystrophic skeletal muscle, clarified a much debated issue regarding discrepancies seen for laminin α1-chain expression between human and mouse tissues. Lack of laminin α1-chain expression was verified in both mouse and human skeletal muscle. Furthermore, the earlier discrepancies seen for laminin α1-chain expression was explained by showing that an antibody-reagent, commonly used in human studies, recognised the laminin α5-chain rather than the laminin α1-chain The integrin α11-chain (forming α11β1 integrin) is the latest addition to the integrin receptor family, and belongs to the I domain-containing group of integrin α-chains. Previous studies had shown that α11β1 is a collagen receptor. In the present study, the in vitro and in vivo functions of the α11-chain were further characterised. Distribution studies on embryonic human and mouse tissues showed that the α11-chain was expressed on mesenchymal cells in the developing tendon, perichondrium, intervertebral disc, and cornea. The interactions of α11β1 integrin with collagen type I and IV were studied in vitro. The α11β1 bound to these collagens in a manner similar to integrin α2β1 (with collagen type I being the preferred ligand for α11β1). Furthermore, α11β1 was shown to mediate migration on collagen type I coated surfaces, and to mediate contraction of collagen type I gels. The in vivo functions of the α11-chain were investigated by the generation of integrin α11-chain null-mice, using gene targeted disruption of the itga11 in embryonic stem cells. Two independent lines of mice lacking α11 protein were generated. Phenotypic analysis of these mice indicated a role for α11β1 in the formation of the musculoskeletal system.
Experimental enterotoxin-induced Escherichia coli diarrhea and protection induced by previous infection with bacteria of the same adhesin or enterotoxin type (1985)

The diarrheal response to an initial and a second infection with Escherichia coli expressing various enterotoxins (the heat-stable toxin [ST] alone or in combination with the heat-labile toxin [LT]) and colonization factor antigens (CFA/I, CFA/II, or E8775-type) was studied in the reversible tie adult rabbit diarrhea model. An initial infection with high doses (1 X 10(10) to 5 X 10(11) bacteria) of the various strains regularly induced diarrhea which was usually self-limiting (only 7 of 85 animals died). The diarrheal response to equally effective doses of different strains producing both ST and LT (ST/LT) did not differ significantly with serotype or colonization factor antigen. ST/LT-producing strains appeared to induce severe disease more regularly than ST-producing strains carrying the same adhesin. Previous infection with CFA/I-carrying, ST/LT-producing E. coli protected all animals reinfected with an otherwise highly diarrheogenic dose of the same strain as well as against challenge with a CFA/I-carrying, ST/LT-producing strain with different O-, K-, and H-antigens. Fecal excretion of bacteria was also significantly reduced in the protected animals, although not completely eliminated. When only one of the two antigens, CFA/I and LT, was shared by the immunizing and rechallenge strains, partial protection was evident consistent with independent antibacterial (anti-CFA) and antitoxic (anti-LT) immune mechanisms. Oral immunization with purified CFA/I significantly reduced fluid secretion in intestinal loops infected with CFA/I-carrying enterotoxigenic bacteria.
Remote Sensing Processing: From Multicore to GPU (2011)

As the amount of data and the complexity of the processing rise, the demand for processing power in remote sensing applications is increasing. The processing speed is a critical aspect to enable a productive interaction between the human operator and the machine in order to achieve ever more complex tasks satisfactorily. Graphic processing units (GPU) are good candidates to speed up some tasks. With the recent developments, programming these devices became very simple. However, one source of complexity is on the frontier of this hardware: how to handle an image that does not have a convenient size as a power of 2, how to handle an image that is too big to fit the GPU memory? This paper presents a framework that has proven to be efficient with standard implementations of image processing algorithms and it is demonstrated that it also enables a rapid development of GPU adaptations. Several cases from the simplest to the more complex are detailed and illustrate speedups of up to 400 times.
Iron-alumina nanocomposites prepared by ball milling (1992)

Small magnetic particles of iron embedded in an insulating alumina matrix have been prepared by ball milling, either by direct milling of a mixture of iron and alumina powders or indirectly by ball-milling enhanced displacement reaction between magnetite and aluminum metal. The average particle size could be reduced to the 10-nm range as indicated by X-ray diffraction linewidths and SEM (scanning electron microscopy). The change in the saturation magnetization and the coercivity relates to the change of the phase composition, decrease of the particle size, and accumulation of internal stresses.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Predicting Patient Falls (2007)

In Brief Overview The Hendrich II Fall Risk Model is used to assess a hospitalized patient's risk of falling. Designed to be administered quickly, it focuses on eight independent risk factors: confusion, disorientation, and impulsivity; symptomatic depression; altered elimination; dizziness or vertigo; male sex; administration of antiepileptics (or changes in dosage or cessation); administration of benzodiazepines; and poor performance in rising from a seated position in the Get-Up-and-Go test. (This screening tool is included in a series, Try This: Best Practices in Nursing Care to Older Adults, from the Hartford Institute for Geriatric Nursing at New York University's College of Nursing.) For a free online video demonstrating the use of this tool, go to https://links.lww.com/A111. The author discusses the Hendrich II Fall Risk Model, widely used in determining a hospitalized patient's risk of falling.
Efficacy and Tolerability of a GD2-Directed Trifunctional Bispecific Antibody in a Preclinical Model: Subcutaneous Administration Is Superior to Intravenous Delivery (2015)

Trifunctional bispecific antibodies (trAb) are novel anticancer drugs that recruit and activate different types of immune effector cells at the targeted tumor. Thus, tumor cells are effectively eliminated and a long-lasting tumor-specific T-cell memory is induced. The trAb Ektomab is directed against human CD3 on T cells and the tumor-associated ganglioside GD2, which is an attractive target for immunotherapy of melanoma in humans. To optimize clinical applicability, we studied different application routes with respect to therapeutic efficacy and tolerability by using the surrogate trAb Surek (anti-GD2 × anti-murine CD3) and a murine melanoma engineered to express GD2. We show that subcutaneous injection of the trAb is superior to the intravenous delivery pathway, which is the standard application route for therapeutic antibodies. Despite lower plasma levels after subcutaneous administration, the same tumor-protective potential was observed in vivo compared with intravenous administration of Surek. However, subcutaneously delivered Surek showed better tolerability. This could be explained by a continuous release of the antibody leading to constant plasma levels and a delayed induction of proinflammatory cytokines. Importantly, the induction of counter-regulatory mechanisms was reduced after subcutaneous application. These findings are relevant for the clinical application of trifunctional bispecific antibodies and, possibly, also other immunoglobulin constructs. Mol Cancer Ther; 14(8); 1877-83. ©2015 AACR.
Using Active Learning to Identify Health Information Technology Related Patient Safety Events (2017)

The widespread adoption of health information technology (HIT) has led to new patient safety hazards that are often difficult to identify. Patient safety event reports, which are self-reported descriptions of safety hazards, provide one view of potential HIT-related safety events. However, identifying HIT-related reports can be challenging as they are often categorized under other more predominate clinical categories. This challenge of identifying HIT-related reports is exacerbated by the increasing number and complexity of reports which pose challenges to human annotators that must manually review reports. In this paper, we apply active learning techniques to support classification of patient safety event reports as HIT-related. We evaluated different strategies and demonstrated a 30% increase in average precision of a confirmatory sampling strategy over a baseline no active learning approach after 10 learning iterations.
Data flow coverage and the C language (1991)

This paper reviews some of the difficulties and decisions in implementing data flow coverage criteria for the C language as realized in ATAC, a data flow coverage testing tool for C. We also address a particular, language independent problem with the concept of the all-du-paths data flow coverage criterion and suggest a solution.
Advice Goes Virtual: How New Digital Investment Services are Changing the Wealth Management Landscape (2015)

The emergence of a new group of digital wealth management firms offering automated investment advice services has quickly become one of the most frequently debated topics in the industry. Comparisons are being made to the travel industry of the 1990s, when the travel agent model lost ground to online services such as Expedia, and some media outlets and analysts are predicting that the emerging start-ups will revolutionize how wealth management advice is provided. Yet others have discounted and labeled this “robo-advisor” movement as unproven and believe its solutions are no match for human personalized investment advice. In this context, we wanted to explore these new firms to understand the innovations they are offering and their aspirations for the future and answer some of the questions many in the industry are asking. Are these firms going to challenge the traditional wealth management model and change the industry landscape? Is there a large enough market for their services beyond the young, tech- savvy client segment they have attracted so far? And, if the underlying changes (e.g., client experience, new potential client segments) are permanent, what should traditional firms do? This report presents our insights and perspectives based on numerous interviews and discussions with senior executives across the industry, including traditional wealth managers and digital entrants, as well as secondary market research. Our key findings are as follows: digital entrants use a combination of simplified client experience, lower fees and increased transparency to offer automated advice direct to consumers; the new models have the potential to make advice for the mass market feasible at last; the changes digital firms have introduced are here to stay, so traditional players need to determine if and how they want to approach them. In summary, our view is that the emergence of digital entrants into the wealth management space will indeed change the industry in several ways. This will ultimately benefit new and existing investors alike by providing better and more affordable products and services through an improved client experience.
Pharmacogenetic association with adverse drug reactions to azathioprine immunosuppressive therapy following liver transplantation (2005)

Azathioprine (AZA) is a thiopurine prodrug commonly used in triple-immunosuppressive therapy following liver transplantation. Approximately 1 in 10 patients suffers side effects in response to the drug, the most problematic being bone marrow toxicity. There is evidence that polymorphisms in the genes encoding thiopurine methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPase) predict adverse drug reactions to AZA therapy. Furthermore, common genetic polymorphisms in the gene encoding methylenetetrahydrofolate reductase (MTHFR) may have an indirect impact on thiopurine drug methylation by influencing levels of the methyl donor S-adenosylmethionine (SAM). The aim of this study was to determine whether polymorphisms in these candidate pharmacogenetic loci predict adverse drug reactions to AZA immunosuppressive therapy in liver transplant patients. A series of 65 liver transplant recipients were recruited to the study from the Liver Transplant Out-Patient clinic at The Royal Infirmary of Edinburgh. Clinical response to AZA was retrospectively correlated against TPMT activity, TPMT*2, *3A, and *3A genotypes, inosine triphosphatase (ITPA) 94C>A and IVS2+21A>C genotypes, and MTHFR 677C>T and 1298A>C genotypes. Variant TPMT, ITPA, and MTHFR genotypes were not significantly associated with adverse drug reactions to AZA, including bone marrow suppression. However, the 2 patients who suffered nodular regenerative hyperplasia (NRH) were both heterozygous for the TPMT*3A mutation. In conclusion, our findings suggest that TPMT, ITPA, and MTHFR genotypes do not predict adverse drug reactions, including bone marrow suppression, in liver transplant patients. However, the possible association between NRH and a heterozygous TPMT genotype should be investigated further.
Pressure-Driven Reverse-Phase Liquid Chromatography Separations in Ordered Nonporous Pillar Array Columns (2007)

Building upon the micromachined column idea proposed by the group of Regnier in 1998, we report on the first high-resolution reversed-phase separations in micromachined pillar array columns under pressure-driven LC conditions. A three component mixture could be separated in 3 s using arrays of nonporous silicon pillars with a diameter of approximately 4.3 microm and an external porosity of 55%. Under slightly retained component conditions (retention factor k' = 0.65-1.2), plate heights of about H = 4 microm were obtained at a mobile phase velocity around u = 0.5 mm/s. In reduced terms, such plate heights are as low as hmin = 1. Also, since the flow resistance of the column is much smaller than in a packed column (mainly because of the higher external porosity of the pillar array), the separation impedance of the array was as small as E = 150, i.e., of the same order as the best currently existing monolithic columns. At pH = 3, yielding very low retention factors (k' = 0.13 and 0.23), plate heights as low as H = 2 microm were realized, yielding a separation of the three component mixture with an efficiency of N = 4000-5000 plates over a column length of 1 cm. At higher retention factors, significantly larger plate heights were obtained. More experimental work is needed to investigate this more in depth. The study is completed with a discussion of the performance limits of the pillar array column concept in the frame of the current state-of-the-art in microfabrication precision.
Specialising for High Performance FFT Algorithms Based on Fixed-Point DSP (2006)

During FFT computation, energy leakage and picket-fence effect are the most critical error sources derived from FFT algorithms; meanwhile, data truncation and rounding during the butterfly calculation implemented by fixed-point DSP can make even more significant error due to finite wordlength. Based on some established FFT spectrum correction algorithms, an improved double-windowing method is presented, and an extended-precision FFT scheme for fixed-point DSP application is put forward. The feasibilities of the two reformative methods are discussed theoretically, and the validities are testified by the simulation results
Large Tunneling Anisotropic Magnetoresistance in (Ga,Mn)As Nanoconstrictions (2005)

We report a large tunneling anisotropic magnetoresistance (TAMR) in (Ga,Mn)As lateral nanoconstrictions. Unlike previously reported tunneling magnetoresistance effects in nanocontacts, the TAMR does not require noncollinear magnetization on either side of the constriction. The nature of the effect is established by a direct comparison of its phenomenology with that of normal anisotropic magnetoresistance (AMR) measured in the same lateral geometry. The direct link we establish between the TAMR and AMR indicates that TAMR may be observable in other materials showing room temperature AMR and demonstrates that the physics of nanoconstriction magnetoresistive devices can be much richer than previously thought.
VCore-based design methodology (2003)

The VCore [1](*) based design methodology, which has been developed at the VCDS (**) Project, is a SoC design methodology using VCores. A VCore is a reusable, high level abstracted design component. We have developed the VCore based design methodology and the VCDS tool prototype. We used the developed tool and did a trial SoC design. The design result showed that SoC design productivity improved using the proposed methodology.VCDS: Virtual Core based Design SystemVCore: Virtual Core
Study of symptoms in middle life with special reference to the menopause. (1980)

In an attempt to clarify the nature of the "menopausal syndrome" a survey of symptoms was carried out by means of postal questionnaires in a population sample of 1120 women and 510 men. Special care was taken to avoid letting the participants know that the survey was mainly concerned with the menopause. Response rates were 72% for women and 68% for men. Analysis of patterns of symptoms by age and sex showed that peaks of prevalence of flushing and sweating were closely associated with the mean age of menopause, coinciding with it or occurring a little after it. Less impressive peaks of prevalence of a group of minor mental symptoms were associated with an age just preceding the mean age of menopause. Complaints about aching breasts, irritability, and low backache diminished after the menopause. No association with the menopause was found for various other symptoms. The results of this study support the view that the menopausal syndrome exists but do not, of course, provide any evidence concerning the effectiveness (or safety) of hormone treatment.
New Obligate Methylotroph (1972)

A new and unique obligate methylotroph was isolated from enrichment cultures with methanol as the sole source of carbon and energy. The organism grows only on methanol and methylamine and not on methane. It does not have a complex intracellular membrane system. (14)C-acetate was assimilated by growing cultures and cell suspensions but was incorporated into only a limited number of cell constituents. (14)C-acetate incorporation was strictly dependent on the oxidation of methanol or methylamine as a source of energy. Extracts had relatively low levels of enzymes of the tricarboxylic acid cycle, and alpha-ketoglutarate dehydrogenase was not detected. Comparisons were made with a facultative methylotroph isolated from the same enrichment cultures. The new obligate methylotroph contained hexose phosphate synthetase, a key enzyme in the ribose phosphate cycle of methyl metabolism.
Manganese Cupferronate (1996)

In the title compound, bis­(N-nitroso-N-phenylhydroxylaminato)manganese, [Mn(C6H5N2O2)2], the MnII ion has a distorted octahedral coordination defined by four O atoms from two cupferron ligands and two O atoms of the nitroso groups of two adjacent cupferron ligands [Mn-O 2.142 (2)–2.198 (2) Å]. Each nitroso O atom coordinates to two MnII ions resulting in an (-Mn-O-Mn-)n network. The plane of the nitrosohydroxylaminato group is nearly coplanar with that of the phenyl ring.