gebhart/patrepeval huggingface dataset:
Evaluation and Management of Oropharyngeal Dysphagia in Head and Neck Cancer (2002)

To improve safety of oral intake, normalize nutritional status, reduce complications of cancer treatment and enhance quality of life, accurate identification of swallowing disorders and efficient management of dysphagia symptoms must be achieved in an interdisciplinary team environment.
Cell source determines the immunological impact of biomimetic nanoparticles (2015)

Recently, engineering the surface of nanotherapeutics with biologics to provide them with superior biocompatibility and targeting towards pathological tissues has gained significant popularity. Although the functionalization of drug delivery vectors with cellular materials has been shown to provide synthetic particles with unique biological properties, these approaches may have undesirable immunological repercussions upon systemic administration. Herein, we comparatively analyzed unmodified multistage nanovectors and particles functionalized with murine and human leukocyte cellular membrane, dubbed Leukolike Vectors (LLV), and the immunological effects that may arise in vitro and in vivo. Previously, LLV demonstrated an avoidance of opsonization and phagocytosis, in addition to superior targeting of inflammation and prolonged circulation. In this work, we performed a comprehensive evaluation of the importance of the source of cellular membrane in increasing their systemic tolerance and minimizing an inflammatory response. Time-lapse microscopy revealed LLV developed using a cellular coating derived from a murine (i.e., syngeneic) source resulted in an active avoidance of uptake by macrophage cells. Additionally, LLV composed of a murine membrane were found to have decreased uptake in the liver with no significant effect on hepatic function. As biomimicry continues to develop, this work demonstrates the necessity to consider the source of biological material in the development of future drug delivery carriers.
Polymer wedge for perfectly vertical light coupling to silicon (2009)

We present the design and fabrication of a refractive polymer wedge that allows perfectly vertical coupling of light into a silicon waveguide, which is of interest for flip-chip bonding of vertical cavity emitting light sources on a silicon integrated circuit. The structure includes a conventional diffractive grating coupler that requires off-normal incidence to avoid second order Bragg reflections. The polymer wedge is thus used to refract vertically impinging light into an off-normal wave that couples into the underlying grating. The fabrication involves two steps: mold fabrication and imprint replication. Firstly negative wedge-shaped craters are etched into a quartz mold by Focused-ion-beam milling. Secondly the mold is used to imprint a UV-curable polymer onto a silicon chip containing waveguides and grating couplers, and so replicating the wedges. The characterization setup consisted of a fiber-to-fiber transmission measurement of a silicon waveguide equipped with a pair of grating couplers and polymer wedges. The obtained fiber coupling efficiency was equal to the efficiency of regular grating couplers and fiber positioned at an off-normal angle. The proposed fabrication method enables low cost integration of vertical cavity emitting light sources on silicon integrated photonic circuits.
Distribution of autolysins in hyphae of Aspergillus nidulans: evidence for a lipid-mediated attachment to hyphal walls (1978)

Preparations of broken Aspergillus nidulans hyphae contained both free and wall-bound autolysins. The bound enzymes were not solubilized by 8 M LiCl or neutral or anionic detergents; they were readily detached from walls by a cationic detergent or by autodigestion. Once detached, the enzymes did not reassociate with wall to give salt-resistant complexes. Six enzymes hydrolyzing wall polymers were bound to the envelope, and the same activities were also detected among soluble proteins in the cytoplasmic fraction. It is suggested that cytoplasmic vesicles, containing autolysins, are inserted into or trapped by newly formed wall in the growing hypha; these constitute the wall-bound autolysin fraction. Starvation for a carbon source derepressed the synthesis of five out of the six autolysins, and the amounts of both soluble and wall-bound activities increased by one to two orders of magnitude.
A sharp programmable passive filter based on filtering by Aliasing (2015)

This paper presents the 1 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">st</sup> integrated circuit demonstration of Filtering by Aliasing (FA). FA is a recent technique that uses linear periodically time varying (LPTV) analog circuitry prior to a sampler to provide a desired CT-to-DT transfer function. Such LPTV signal processing offers far superior programmability and performance relative to LTI design. The presented IC applies FA to a single-pole passive RC filter. The resistor, realized as a switched resistor ladder, is continuously varied using on-chip digital control while the output is sampled at a baseband rate. Measured CT-to-DT responses show tunable-bandwidth filter roll-off better than 60 dB/dec, stop-band suppression up to 60 dB, tunable carrier up to 800 MHz, up to 31 dBm out-of-band IIP3, and harmonic rejection.
Assessment of Human Tumour Proliferation Using Bromodeoxyuridine—Current Status (1991)

The study of human tumour proliferation has been facilitated by the development of monoclonal antibodies recognizing halogenated pyrimidines. Flow cytometry can be used to detect the incorporation of bromodeoxyuridine (BUdR) into DNA simultaneously with the measurement of total DNA content. We have studied in excess of 600 tumours using in vivo administration of BUdR. The cell kinetic information generated from this approach is more complete than can be obtained from in vitro incubation with DNA precursors such as tritiated thymidine (3HTdR) or by single parameter DNA analysis. The duration of S-phase (Ts) can be estimated in addition to the labelling index (LI). From these two parameters, the potential doubling time (Tpot) can be calculated. Our data show a wide variation in Ts as well as LI, making both these parameters important variants in determining overall proliferation. Although there is tremendous variation in Tpot between tumours of the same and different types, the median values are surprisingly short at around 5 days. A close relationship exists between the presence of DNA aneuploidy and the proliferation parameters. The clinical relevance of Tpot is currently being assessed independently in two trials of accelerated versus conventional fractionation.
CHARACTERISTICS OF CONCORD GRAPE POLYPHENOLOXIDASE INVOLVED IN JUICE COLOR LOSS (1976)

ABSTRACT The factors affecting postharvest color losses in Concord grapes were investigated, with emphasis on the extraction, partial purification and characterization of naturally occurring enzymes that may be involved. Color losses were accelerated in Concord juice by the crude enzyme extracted from the grapes. Catechol was oxidized more rapidly than other o ‐dihydroxyphenols, although pyrogallol, caffeic acid and dl‐DOPA were good substrates for the crude polyphenoloxidase (PPO). The optimum activity was in the pH range 5.9–6.3 and at temperatures 25–30°C. Kinetic data for the crude enzyme showed a Michaelis constant of 67 mM of catechol at pH 6.0. Effective inhibitors were Na 2 S 2 O 5 , dithiothreitol, phenylhydrazine, cysteine and others. Peroxidase (PRO) activity of the crude extract was very low in ripe Concord grapes. Anthocyanin pigment degradation by the crude enzyme extract was dependent on maturity of the grapes. The most rapid degradation of pigment occurred when crude enzyme from ripe grapes was added.
Evolution of an intelligent network (2003)

An intelligent network structure, its original technology, and the advanced services it can provide are described. The issues of traffic control, customized processing, multi-connection control and virtual network service control points (NSPs) are addressed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Ultra-low power monolithically integrated InGaAs/GaAs phototransceiver incorporating a modulated barrier photodiode and a quantum dot microcavity LED (2002)

We report the design and performance characteristics of GaAs-based low-power phototransceivers which offer large optical gain and very low power dissipation. In these monolithically integrated circuits we have integrated modulated barrier photodiodes with quantum dot-based microcavity LEDs. Quantum dots promise higher quantum efficiency, higher power, together with a more directed emission profile.
COCA: Computation Offload to Clouds Using AOP (2012)

In this paper, we describe COCA -- Computation Offload to Clouds using AOP (aspect-oriented programming). COCA is a programming framework that allows smart phones application developers to offload part of the computation to servers in the cloud easily. COCA works at the source level. By harnessing the power of AOP, COCA inserts appropriate offloading code into the source code of the target application based on the result of static and dynamic profiling. As a proof of concept, we integrate COCA into the Android development environment and fully automate the new build process, making application programming and software maintenance easier. With COCA, mobile applications can now automatically offload part of the computation to the cloud, achieving better performance and longer battery life. Smart phones such as iPhone and Android phones can now easily leverage the immense computing power of the cloud to achieve tasks that were considered difficult before, such as having a more complicated artificial-intelligence engine.
Strong Cryptography Armoured Computer Viruses Forbidding Code Analysis: the Bradley Virus 1 (2004)

Imagining what the nature of future viral attacks might look like is the key to successfully protecting against them. This paper discusses how cryptography and key management techniques may definitively checkmate antiviral analysis and mechanisms. We present a generic virus, denoted bradley which protects its code with a very secure, ultra-fast symmetric encryption. Since the main drawback of using encryption in that case lies on the existence of the secret key or information about it within the viral code, we show how to bypass this limitation by using suitable key management techniques. Finally, we show that the complexity of the bradley code analysis is at least as high as that of the cryptanalysis of its underlying encryption algorithm.
Comparison of split-beam transducer geometries and excitation configurations for transrectal prostate HIFU treatments (2002)

Six split-beam transducer configurations have been examined using computer simulations and in-vitro experiments. The goal of this study was to identify a simple split-beam transducer configuration capable of reducing transrectal high intensity focused ultrasound (HIFU) prostate cancer treatment time without sacrificing treatment safety and efficacy. Lesion volume, lesion and rectal wall temperatures, sonication ON/OFF time, and total acoustic power parameters were used as comparison criteria. The most promising split-beam configuration generates necrosed tissue volumes 5 times larger than the single-element transducer with the same sonication time, while keeping maximum focal zone temperatures below 90/spl deg/C. These parameters yield approximate overall treatment time reductions by a factor of 1.85 as compared to single-element transrectal HIFU PC treatments, mainly due to longer tissue cooling time required to maintain current safety levels.
A system for the seamless integration of personal messages using agents developed on a Lotus Notes platform (1996)

We introduce a seamless messaging system for the management of personal messages. The aim of it is to intercept, filter, interpret, and deliver multi-modal messages (voice, fax, and/or e-mail messages). Messages are delivered to the recipient regardless of their target messaging device. Seamless messaging involves finding the person (if urgent) and delivering the information to them on their cellular phone, pager, laptop, nearest fax, telephone, or workstation. The system includes a set of personal agents that classify and act on incoming messages based on theircontent. The user specifies the classes and actions to the agent as a set of high-level rules. This allows the user to specify rules that are independent of the messaging system and target devices. A personal agent "Secretary" is responsible for mediating between the different messaging environments, the target devices, and other interacting applications (e.g., calendars, e-mail programs, etc.).The design of this Seamless Messaging System is based on the integration of three technologies,ubiquitous computing, information filtering, and telematics. The system has beenimplemented on a Lotus Notes platform. What makes the system unique is its approach to treating a message in a universal manner, its ability to mediate between different messaging devices, and its ability to try to determine the availability of the user.
De novo discovery of a tissue-specific gene regulatory module in a chordate (2005)

We engage the experimental and computational challenges of de novo regulatory module discovery in a complex and largely unstudied metazoan genome. Our analysis is based on the comprehensive characterization of regulatory elements of 20 muscle genes in the chordate, Ciona savignyi. Three independent types of data we generate contribute to the characterization of a muscle-specific regulatory module: (1) Positive elements (PEs), short sequences sufficient for strong muscle expression that are identified in a high-resolution in vivo analysis; (2) CisModules (CMs), candidate regulatory modules defined by clusters of overrepresented motifs predicted de novo; and (3) Conserved elements (CEs), short noncoding sequences of strong conservation between C. savignyi and C. intestinalis. We estimate the accuracy of the computational predictions by an analysis of the intersection of these data. As final biological validation of the discovered muscle regulatory module, we implement a novel algorithm to search the genome for instances of the module and identify seven novel enhancers.
Bolted and Bonded Joints (2001)

Abstract This article provides a discussion on adhesively bonded joints and elastic-plastic mathematical model for an adhesive in shear. It discusses the design rules for thin bonded structures and reviews computer programs for the highly loaded stepped-lap joints. The article describes the two-dimensional effects associated with load redistribution around flaws and with damage tolerance. The elastic-isotropic geometric stress-concentration factors and empirically established correlation factors of mechanically fastened joints are discussed. The article provides information on the identification of optimal joint proportions for single-row joints, and the design and analysis of the stronger multirow joints, with particular regard to the bearing-bypass interaction.
Zur Prins‐Reaktion von Lumihecogeninacetat (1981)

Abstract Durch photochemische Umlagerung von Hecogeninacetat ( 1 ) zum ungesättigten Aldehyd 5 und anschließende Prins‐Reaktion sind die 14β‐Hydroxysteroide 7a und 10a bequem zugänglich. Die Konfiguration an C‐13 und C‐14 bei 7a, 10a und 9a wurde chemisch und mit Hilfe spektroskopischer Methoden ( 1 H‐NMR, 13 C‐NMR und CD) abgeleitet.
Effect of Pentane-1,5-diol and Propane-1,2-diol on Percutaneous Absorption of Terbinafine (2009)

The aim of this study was to compare pentane-1,5-diol and propane-1,2-diol used as absorption enhancers for cutaneously administered terbinafine. Fresh human skin samples were placed in a continuous flow diffusion cell with a gel containing terbinafine on top of the skin. Receptor fluid samples were analysed using high - performance liquid chromatography. The quantity of gel remaining on the skin surface after completion of each test was weighed and the amount of drug in the skin was analysed. Addition of pentane-1,5-diol or propane-1,2-diol to the gel increased the percutaneous absorption of the drug. The most efficient absorption enhancer in this comparison was 5% pentane-1,5-diol.
A simple assay for a human serum phospholipase A2 that is associated with high-density lipoproteins (2001)

Phospholipase A2 (PLA2) activity is usually assayed with expensive radioactive or chromogenic substrates unsuitable for performing large numbers of assays. We have designed a simple microplate assay for human serum PLA2 using the chromogenic substrate 4-nitro-3-octanoyloxy-benzoic acid. Using this substrate, serum PLA2 activity was similar to that measured with the previously characterized chromogenic phospholipid substrate 1,2-bis-heptanoylthio-glycerophosphocholine. However, the assay described here appears to be more sensitive. The mean PLA2 activity in serum from healthy volunteers (n = 30) measured by this assay was 10.4 +/- 1.6 micromol x h(-1) x ml(-1). The assay is reproducible and is suitable for the analysis of large numbers of samples in a clinical setting. We have also demonstrated that 94% of the PLA2 activity in normal human serum is associated with high-density lipoproteins and that serum PLA2 activity is positively correlated with the lipoprotein parameters total triglyceride (P < 0.0001), total cholesterol (P < 0.0001), and atherogenic index (P = 0.008). The serum PLA2 activity was calcium dependent and was inhibited by the serine protease inhibitor 3,4-dichloroisocoumarin (EC(50) = 0.4 mM). The PLA2 activity characterized here is unlikely to be due to plasma platelet-activating factor acetylhydrolase or low molecular weight His-Asp sPLA2, and may represent a new sPLA2 type.
Event Detection and Summarization in Soccer Videos Using Bayesian Network and Copula (2013)

Semantic video analysis and automatic concept extraction play an important role in several applications; including content-based search engines, video indexing, and video summarization. As the Bayesian network is a powerful tool for learning complex patterns, a novel Bayesian network-based method is proposed for automatic event detection and summarization in soccer videos. The proposed method includes efficient algorithms for shot boundary detection, shot view classification, mid-level visual feature extraction, and construction of the related Bayesian network. The method contains of three main stages. In the first stage, the shot boundaries are detected. Using the hidden Markov model, the video is segmented into large and meaningful semantic units, called play-break sequences. In the next stage, several features are extracted from each of these units. Finally, in the last stage, in order to achieve high level semantic features (events and concepts), the Bayesian network is used. The basic part of the method is constructing the Bayesian network, for which the structure is estimated using the Chow-Liu tree. The joint distributions of random variables of the network are modeled by applying the Farlie-Gumbel-Morgenstern family of Copulas. The performance of the proposed method is evaluated on a dataset with about 9 h of soccer videos. The method is capable of detecting seven different events in soccer videos; namely, goal, card, goal attempt, corner, foul, offside, and nonhighlights. Experimental results show the effectiveness and robustness of the proposed method on detecting these events.
Dewatering of foam-laid and water-laid structures and the formed web properties (2019)

Abstract The use of aqueous foams as a carrier fluid for pulp fibers instead of water has re-emerged in the paper and board industry in recent years. In foam forming, a surfactant is needed to reduce the surface tension of the carrier liquid and to create foam as a process fluid and flowing medium. This presents the following questions: (1) How do the water forming and foam forming processes differ? (2) How do the obtained wet/dry fibre sheets differ after forming and after wet pressing? (3) Which differences in the process behavior and sheet properties are due to the surfactant, and which are due to the presence of air bubbles in the flowing medium? The answers to these questions were sought by using an experimental academic approach and by applying a special dynamic vacuum assisted sheet former. Although foams are much more viscous than water, dewatering times were found to be approximately equal in water and foam forming at higher vacuum levels. The hydrodynamic resistance of sheet was approximately constant during water forming, while in foam forming resistance was initially even smaller than in water forming but it increased with time, being substantially higher at the end of the forming process. In certain cases, surfactant alone was found to have a similar, albeit often lower, effect on the sheet properties of foam. Surfactant improved sheet dryness (both after forming and wet pressing), lowered density, and lowered strength properties also in water forming. Foam, on the other hand, had a crucial effect particularly on certain structural properties such as formation and porosity. The difference between water and foam-laid sheets typically reduced in line with higher wet pressing pressure. This suggests that the role of surface tension and foam bubbles in controlling interfiber contact is overridden by wet pressing pressure. Thus applying foam as a carrier fluid has characteristic effects both on the papermaking process and the end product properties. The main features of foam forming can be explained by the chemical effects caused by the surfactant, and the structural effects caused by the foam bubbles. Graphic abstract
Electrostatic Potential Mapping across AlGaAs/AlAs/GaAs Heterostructure (2008)

Extended abstract of a paper presented at Microscopy and Microanalysis 2008 in Albuquerque, New Mexico, USA, August 3 – August 7, 2008
Synthesis and Catalytic Properties of Phenylene-Bridged Binuclear Organolanthanide Complexes (2008)

Using base-free Ln[N(SiHMe2)2]3 complexes as highly effective protodeamination reagents, the binuclear lanthanide complexes p-bis{η5-(2,3,4,5-tetramethylcyclopentadienyl)Ln[N(SiHMe2)2]2}phenylene [p-Ln2] (Ln = Y, La, Lu) and m-bis{η5-(2,3,4,5-tetramethylcyclopentadienyl)La[N(SiHMe2)2]2}phenylene [m-La2] were synthesized from the corresponding phenylene-linked tetramethylcyclopentadienes. The resulting products serve as new types of multicenter homogeneous 4f catalysts. Reactivity studies reveal that these binuclear organolanthanide complexes efficiently catalyze the intramolecular hydroamination/cyclization of aminoalkenes, aminoalkynes, and aminodienes, with turnover frequencies as high as 10 h−1 at 60 °C.
Curing and thermal behavior of epoxy resins of hexafluoro - bisphenol –A and bisphenol-A (2016)

This paper describes the synthesis and characterization of epoxy resins based on (hexafluoroisopropylidene)diphenol (EFN) and p,p’-isopropylidenebisphenol (EBN), respectively and 4, 4’- (hexafluoroisopropylidene)dipthalic-imideamine (IMAM), a curing agent. The synthesized epoxy resins and IMAM curing agent were characterized by Fourier Transform Infrared (FTIR) and 1H Nuclear Magnetic Resonance (NMR) spectroscopy.13C NMR technique was also used to characterize IMAM. Study of curing behavior of EFN and EBN with stoichiometric amount of aromatic 4,4’-diaminodiphenylmethane (DDM), 4,4’-diaminodiphenylsulfone (DDS) and IMAM by using Differential Scanning Calorimetery (DSC) indicated that IMAM was least reactive curing agent towards both epoxy resins as compared to DDS and DDM. The investigation of thermal decomposition of the cured compounds by thermogravimetric analyzer (TGA) indicated the higher thermal stability of EFN and EBN resins initially with DDS and at elevated temperatures with IMAM. It was also observed that EFN resins were thermally more stable than EBN resins cured with corresponding curing agents.