gebhart/patrepeval huggingface dataset:
Sleep disturbances in Parkinson's disease patients and management options (2011)

Sleep disturbances are among the most common nonmotor complaints of patients with Parkinson's disease (PD), and can have a great impact on quality of life. These disturbances manifest in a variety of ways; for instance, insomnia, sleep fragmentation, and excessive daytime sleepiness. Sleep-related movement disorders such as restless legs syndrome and periodic leg movements may share a common pathophysiology, and occurrence of rapid eye movement behavior disorder may predate the onset of PD or other synucleinopathies by several years. Medications for PD can have a significant impact on sleep, representing a great challenge to the treating physician. Awareness of the complex relationship between PD and sleep disorders, as well as the varied way in which sleep disturbances appear, is imperative for successful long-term management.
Global-to-Local Shape Matching for Liver Segmentation in CT Imaging (2007)

Abstract. We propose a two-stage algorithm to segment the liver in CT images. First, we estimate the pose and global shape properties using a statistical shape model defined in the low dimensional space spanned by a training set of shapes. Then, we apply a template matching procedure to recover local deformations that were not present in the learning set. In both steps, we optimize the same image term: the likelihood of the intensity inside the region of interest and its background. The method requires a single seed point inside the liver for the initialization. We show that this global-to-local strategy is able to recover livers with peculiar shapes in arbitrary poses. 1
Fast and correct performance recovery of operating systems using a virtual machine monitor (2011)

Rebooting an operating system is a final but effective recovery technique. However, the system performance largely degrades just after the reboot due to the page cache being lost in the main memory. For fast performance recovery, we propose a new reboot mechanism called the warm-cache reboot. The warm-cache reboot preserves the page cache during the reboot and enables an operating system to restore it after the reboot, with the help of a virtual machine monitor (VMM). To perform correct recovery, the VMM guarantees that the reused page cache is consistent with the corresponding files on disks. We have implemented the warm-cache reboot mechanism in the Xen VMM and the Linux operating system. Our experimental results showed that the warm-cache reboot decreased performance degradation just after the reboot. In addition, we confirmed that the file cache corrupted by faults was not reused. The overheads for maintaining cache consistency were not usually large.
The development and characterization of synthetic minimal yeast promoters (2015)

Synthetic promoters, especially minimally sized, are critical for advancing fungal synthetic biology. Fungal promoters often span hundreds of base pairs, nearly ten times the amount of bacterial counterparts. This size limits large-scale synthetic biology efforts in yeasts. Here we address this shortcoming by establishing a methodical workflow necessary to identify robust minimal core elements that can be linked with minimal upstream activating sequences to develop short, yet strong yeast promoters. Through a series of library-based synthesis, analysis and robustness tests, we create a set of non-homologous, purely synthetic, minimal promoters for yeast. These promoters are comprised of short core elements that are generic and interoperable and 10 bp UAS elements that impart strong, constitutive function. Through this methodology, we are able to generate the shortest fungal promoters to date, which can achieve high levels of both inducible and constitutive expression with up to an 80% reduction in size.
ChemInform Abstract: MOLECULAR REQUIREMENTS AT THE CHOLINERGIC RECEPTORS. IMPORTANCE OF ETHER OXYGENS IN THE DIOXOLANE SERIES (1978)

Abstract Ausgehend von dem Tetrahydrofuran (I) bzw. von dem Furan (V) werden die Metoiodide (IV) und (VII) synthetisiert.
Nitrogen Fixation and Hydrogen Metabolism in Cyanobacteria (2010)

This review summarizes recent aspects of (di)nitrogen fixation and (di)hydrogen metabolism, with emphasis on cyanobacteria. These organisms possess several types of the enzyme complexes catalyzing N(2) fixation and/or H(2) formation or oxidation, namely, two Mo nitrogenases, a V nitrogenase, and two hydrogenases. The two cyanobacterial Ni hydrogenases are differentiated as either uptake or bidirectional hydrogenases. The different forms of both the nitrogenases and hydrogenases are encoded by different sets of genes, and their organization on the chromosome can vary from one cyanobacterium to another. Factors regulating the expression of these genes are emerging from recent studies. New ideas on the potential physiological and ecological roles of nitrogenases and hydrogenases are presented. There is a renewed interest in exploiting cyanobacteria in solar energy conversion programs to generate H(2) as a source of combustible energy. To enhance the rates of H(2) production, the emphasis perhaps needs not to be on more efficient hydrogenases and nitrogenases or on the transfer of foreign enzymes into cyanobacteria. A likely better strategy is to exploit the use of radiant solar energy by the photosynthetic electron transport system to enhance the rates of H(2) formation and so improve the chances of utilizing cyanobacteria as a source for the generation of clean energy.
The inflammatory response as a target to reduce myocardial ischaemia and reperfusion injury (2009)

Acute myocardial infarction is the leading cause of morbidity and mortality in the adult population of developed and developing nations. Although the prompt restoration of antegrade blood flow in the infarct-related coronary artery is the mean therapy for improving survival, reperfusion itself may cause damage to ischaemic myocardial tissue. This event is well known as "reperfusion injury". Crucial mediators for cardiac damage in the reperfusion phases are oxidative stress, inflammation and leukocyte infiltration. Already approved and novel therapies might directly reduce these inflammatory processes. Treatments modulating chemokine secretion and activity should be considered as very promising approaches to reduce myocardial reperfusion injury.
Phase I clinical trial to evaluate the safety, tolerability, and pharmacokinetics of high-dose intravenous ascorbic acid in patients with advanced cancer (2013)

Ascorbic acid administered i.v. at 1 g/min for 4 consecutive days/week for 4 weeks produced up to 49 mM ascorbic acid in patient's blood and was well tolerated. The recommended dose for future studies is 70-80 g/m².
Die Bildungssituation ausländischer Mädchen (1985)

Nach Angaben der Kultusministerkonferenz besuchten im Schuljahr 1980/81 736.550 ausländische Schüler die Schulen der Bundesrepublik Deutschland, das waren ca. 11.400 mehr als im vorangegangenen Schuljahr. Der Anteil der Ausländer an der Gesamtschülerzahl in der Bundesrepublik erhöhte sich damit von 5,3% auf 6,3%. Im Schuljahr 1970/71 hatte der entsprechende Anteil noch bei 1,7% gelegen (vgl. Statistische Veröffentlichungen der Kultusministerkonferenz 9/81).
Dual Resistance to <i>Bacillus thuringiensis</i> Cry1Ac and Cry2Aa Toxins in <i>Heliothis virescens</i> Suggests Multiple Mechanisms of Resistance (2003)

One strategy for delaying evolution of resistance to Bacillus thuringiensis crystal (Cry) endotoxins is the production of multiple Cry toxins in each transgenic plant (gene stacking). This strategy relies upon the assumption that simultaneous evolution of resistance to toxins that have different modes of action will be difficult for insect pests. In B. thuringiensis-transgenic (Bt) cotton, production of both Cry1Ac and Cry2Ab has been proposed to delay resistance of Heliothis virescens (tobacco budworm). After previous laboratory selection with Cry1Ac, H. virescens strains CXC and KCBhyb developed high levels of cross-resistance not only to toxins similar to Cry1Ac but also to Cry2Aa. We studied the role of toxin binding alteration in resistance and cross-resistance with the CXC and KCBhyb strains. In toxin binding experiments, Cry1A and Cry2Aa toxins bound to brush border membrane vesicles from CXC, but binding of Cry1Aa was reduced for the KCBhyb strain compared to susceptible insects. Since Cry1Aa and Cry2Aa do not share binding proteins in H. virescens, our results suggest occurrence of at least two mechanisms of resistance in KCBhyb insects, one of them related to reduction of Cry1Aa toxin binding. Cry1Ac bound irreversibly to brush border membrane vesicles (BBMV) from YDK, CXC, and KCBhyb larvae, suggesting that Cry1Ac insertion was unaffected. These results highlight the genetic potential of H. virescens to become resistant to distinct Cry toxins simultaneously and may question the effectiveness of gene stacking in delaying evolution of resistance.
A Massively Parallel Imaging System Based on the Self-Mixing Effect in a Vertical-Cavity Surface-Emitting Laser Array (2006)

In this work we propose a massively parallel self-mixing imaging system, based on an array of VCSELs, to measure surface profiles of displacement, distance, velocity and liquid flow rate. The feasibility of this concept is demonstrated by the successful operation of a small scale prototype consisting of eight individual commercial VCSELs with integrated photodetectors. The system is used to accurately measure the velocity at different radial points on a rotating disk. The results show no influence of crosstalk. A massive version of the system will be useful in many industrial and biomedical applications where real-time surface profiling, vibrometry and velocimetry will be very beneficial.
A New Method for the Purification of DNA‐Binding Proteins with Sequence Specificity (1980)

We describe a technique for a rapid and efficient isolation and purification of proteins binding to defined DNA sequences. Cloned double-stranded DNA was covalently coupled to m-aminobenzyloximethylcellulose in order to purify proteins which recognize and bind to specific sequences on the DNA. The purification of two DNA-binding proteins from Drosophila melanogaster is demonstrated using the respective cloned DNA sequences.
Vitamin A is present as retinol in the tears of humans and rabbits (1984)

Vitamin A is required for the normal growth maintenance and maturation of the corneal epithelium and is effective in the treatment of xerophthalmia and experimental corneal epithelial wounds when applied topically as retinoic acid. The normal route of delivery of vitamin A to the cornea has remained undefined. We collected tears from normal and vitamin A deficient rabbits and from humans and analyzed them by high pressure liquid chromatography. A peak corresponding to a retinol standard was eluted from normal rabbit and human tears but was absent from the vitamin A deficient rabbit tears. The retinol concentration in rabbit tears was 69 ng/ml (0.2 X 10(-6)M) and in human tears was 16 ng/ml (0.5 X 10(-7)M). This demonstration that vitamin A is present in the tears as retinol establishes the rationale for treatment of corneal disease with topical vitamin A.
Targeted Measles Virus Vector Displaying Echistatin Infects Endothelial Cells via αvβ3 and Leads to Tumor Regression (2005)

Targeting tumor-associated vascular endothelium by replication-competent viral vectors is a promising strategy for cancer gene therapy. Here we describe the development of a viral vector based on the Edmonston vaccine strain of measles virus targeted to integrin alpha(v)beta3, which is expressed abundantly on activated but not quiescent vascular endothelium. We displayed a disintegrin, M28L echistatin that binds with a high affinity to integrin alpha(v)beta3 on the COOH terminus of the viral attachment (H) protein and rescued the replication-competent recombinant virus by reverse genetics. The new targeted virus was named measles virus echistatin vector (MV-ERV). Its native binding to CD46 was purposefully retained to allow virus infection of tumor cells expressing this receptor. MV-ERV correctly displayed echistatin on the outer surface of its envelope and produced interesting ring formation phenomena due to cell detachment upon infection of susceptible Vero cells in vitro. MV-ERV grew to 10(6) plaque-forming units/mL, slightly lower than the parental Edmonston strain of measles virus (MV-Edm), but it selectively infected Chinese hamster ovary cells expressing integrin alpha(v)beta3. It also selectively infected both bovine and human endothelial cells on matrigels and unlike MV-Edm, MV-ERV infected newly formed blood vessels in chorioallantoic membrane assays. In animal models, MV-ERV but not the control MV-Edm caused the regression of s.c. xenografts of resistant multiple myeloma tumors (MM1) in severe combined immunodeficient mice. The tumors were either completely eradicated or their growth was significantly retarded. The specificity, potency, and feasibility of MV-ERV infection clearly show the potential use of MV-ERV in gene therapy for targeting tumor-associated vasculature for the treatment of solid tumors.
THE ROLE OF THE <i>FHIT/FRA3B</i> LOCUS IN CANCER (1998)

Common fragile sites form gaps at characteristic chromosome bands in metaphases from normal cells after aphidicolin induction. The distribution of common fragile sites parallels the positions of neoplasia-associated chromosomal rearrangements, prompting the proposal that fragility disposes to chromosomal rearrangements. Implicit in this hypothesis is that genes at fragile sites are altered by chromosome rearrangement and thus contribute to neoplastic growth. Chromosome band 3p14.2, encompassing the most inducible common fragile region, FRA3B, has been cloned and the FHIT gene, straddling FRA3B, characterized. The gene is inactivated by deletions in cancer-derived cell lines and primary tumors and Fhit protein is absent or reduced in lung, stomach, kidney, and cervical carcinomas, consistent with function as a tumor suppressor. FRA3B thus fulfills the prophecy that fragile site alterations contribute to the neoplastic process through inactivation of a tumor suppressor gene.
Enhanced gain of a free-electron laser (1978)

The gain of a free-electron laser may be multiplied by a very large factor when a uniform magnetic field ${B}_{0}$ is superimposed on the extant helical field. The effect is due to cyclotron resonance and requires ${B}_{0}=\frac{10.6}{l{(1\ensuremath{-}\frac{{v}_{\ensuremath{\parallel}}^{2}}{{c}^{2}})}^{\frac{1}{2}}}$ kG, where $l$ is the period of the helical field and ${v}_{\ensuremath{\parallel}}$ is the streaming-electron velocity.
Issues in wireless mobile computing (2003)

The trend toward possible computers with interfaces to wireless network technologies is examined. The question of needed research and specification of hardware is discussed, the major challenges, such as services for the mobile user, mobile internetworking and adjusting to new technologies are described, and a listing of outstanding questions which must be resolved is presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The potential for poly‐α‐amino acids as biomaterials (1974)

Abstract Poly‐α‐amino acids have been investigated for possible use in a wide variety of biomedical applications. These range from dialysis membranes to artificial skin substitutes to degradable sutures. The large number of available α‐amino acids potentially provides an extremely large number of poly‐α‐amino acids. The majority of materials investigated to date are copolymers composed of two components, one of which usually provides the desired property for the given application. This paper deals with the further examination of a series of γ‐benzyl‐ L ‐glutamate‐ L ‐leucine copolymers. Evidence is provided on the effect of these copolymers on the biological environment as determined by implantation in rats up to 200 days. In vitro tests were also performed and the effect of these tests on the stress‐strain properties of one of the copolymers is presented. Preliminary evidence on biodegradable copolymer films is also included. These materials have free γ‐carboxyl groups on the glutamate components.
The clinical significance of tumor necrosis factor-α plasma level in patients having chronic lymphocytic leukemia (2002)

Tumor necrosis factor-alpha (TNF-alpha), a cytokine possessing pleiotropic biological activities, is produced by leukemic lymphocytes in patients with chronic lymphocytic leukemia (CLL) and acts as an autocrine and paracrine growth factor in this disease. In this study, TNF-alpha levels were determined in 150 patients with CLL and correlated with disease characteristics, prognostic factors, and survival. The mean TNF-alpha plasma concentration in the patients with CLL was significantly higher than in the healthy control population (16.4 versus 8.7 pg/mL; P <.0001). Patients having an elevated TNF-alpha level had more advanced Rai and Binet stage disease, higher serum beta(2)-microglobulin (beta(2)M) levels, a greater percentage of cells expressing CD38, and lower hemoglobin and platelet levels. Patients having chromosomal abnormalities such as 11q deletion, trisomy 12, and chromosome 17 aberrations had a higher mean TNF-alpha level (27.5 pg/mL) than patients having a diploid karyotype or other miscellaneous cytogenetic abnormalities (14.2 pg/mL; P <.001). The TNF-alpha level was a predictor of survival when the Cox proportional hazards model was used with TNF-alpha entered as a continuous variable (P =.0001). Also, patients having a TNF-alpha level above the mean value of 14 pg/mL had significantly shorter survival duration (P =.00001). The TNF-alpha level remained predictive of survival in Cox multivariate analysis independent of Rai staging and beta(2)M, hemoglobin, prior therapy, white cell count, and platelet level (P =.005). We conclude that the TNF-alpha level serves as a prognostic factor in patients with CLL and that inhibition of TNF-alpha in these patients could have therapeutic importance.
Influence of dynamic channel allocation on the transmission delay in wireless ATM networks (2002)

During the last few years extensive research has been carried out to extend fixed ATM networks to the mobile user. Several access protocols have been developed and international projects are building the first wireless ATM (WATM) demonstrators. Up to now nearly no research has been done in the area of dynamic channel allocation for WATM networks, which is an essential issue for a future communication system. In the case of a WATM system two different aspects have to be combined: on one hand the ATM like statistical multiplexing leads to a very dynamic assignment of capacity, while on the other hand, dynamic channel allocation requires a steady behaviour. Due to these opposing requirements, a new allocation scheme is required. This paper focuses on the influence on the transmission delay via the ATM air interface caused by this allocation scheme.
Effect of Solvent on Titania Particle Formation and Morphology in Thermal Hydrolysis of TiCl <sub>4</sub> (1997)

Titania powders were synthesized by the thermal hydrolysis of titanium tetrachloride with the yield of above 85% in a mixed solvent of n ‐propanol and water. The morphology of the precipitates was controlled by adjusting the volume ratio of n ‐propanol to water (RH ratio) of the mixed solvent. Precipitates obtained with an RH ratio of 0 were fine, and highly agglomerated. In contrast, an RH ratio of 3 resulted in precipitates consisting of uniform and discrete particles. According to observations of the zeta potentials of precipitates and the dielectric constants of solvents, the discrete particles obtained with an RH ratio of 3 resulted from the low zeta potential and dielectric constant. The result of Fourier transform infrared (FTIR) spectroscopy showed the chemical interaction of particle surface with the solvent alcohol, which decreased the zeta potential of precipitates with an increase of RH ratio. Adding hydroxypropyl cellulose (HPC) as a steric dispersant made it possible to reduce the size of particles to the submicrometer range. Effects of the solvent on the formation and morphology of the resulting particles were investigated.
Functional Role of mTORC2 versus Integrin-Linked Kinase in Mediating Ser473-Akt Phosphorylation in PTEN-Negative Prostate and Breast Cancer Cell Lines (2013)

Although the rictor-mTOR complex (mTORC2) has been shown to act as phosphoinositide-dependent kinase (PDK)2 in many cell types, other kinases have also been implicated in mediating Ser473-Akt phosphorylation. Here, we demonstrated the cell line specificity of integrin-linked kinase (ILK) versus mTORC2 as PDK2 in LNCaP and PC-3 prostate and MDA-MB-468 breast cancer cells, of which the PTEN-negative status allowed the study of Ser473-Akt phosphorylation independent of external stimulation. PC-3 and MDA-MB-468 cells showed upregulated ILK expression relative to LNCaP cells, which expressed a high abundance of mTOR. Exposure to Ku-0063794, a second-generation mTOR inhibitor, decreased Ser473-Akt phosphorylation in LNCaP cells, but not in PC-3 or MDA-MB-468 cells. In contrast, treatment with T315, a novel ILK inhibitor, reduced the phosphorylation of Ser473-Akt in PC-3 and MDA-MB-468 cells without affecting that in LNCaP cells. This cell line specificity was verified by comparing Ser473-Akt phosphorylation status after genetic knockdown of rictor, ILK, and other putative Ser-473-Akt kinases. Genetic knockdown of rictor, but not ILK or the other kinases examined, inhibited Ser473-Akt phosphorylation in LNCaP cells. Conversely, PC-3 and MDA-MB-468 cells were susceptible to the effect of ILK silencing on Ser473-Akt phosphorylation, while knockdown of rictor or any of the other target kinases had no appreciable effect. Co-immunoprecipitation analysis demonstrated the physical interaction between ILK and Akt in PC-3 cells, and T315 blocked ILK-mediated Ser473 phosphorylation of bacterially expressed Akt. ILK also formed complexes with rictor in PC-3 and MDA-MB-468 cells that were disrupted by T315, but such complexes were not observed in LNCaP cells. In the PTEN-functional MDA-MB-231 cell line, both T315 and Ku-0063794 suppressed EGF-induced Ser473-Akt phosphorylation. Inhibition of ILK by T315 or siRNA-mediated knockdown suppressed epithelial-mesenchymal transition in MDA-MB-468 and PC-3 cells. Thus, we hypothesize that ILK might bestow growth advantage and metastatic potential in the course of tumor progression.
The Anti-Tumor Activity of a Neutralizing Nanobody Targeting Leptin Receptor in a Mouse Model of Melanoma (2014)

Environmental and genetic activation of a brain-adipocyte axis inhibits cancer progression. Leptin is the primary peripheral mediator of this anticancer effect in a mouse model of melanoma. In this study we assessed the effect of a leptin receptor antagonist on melanoma progression. Local administration of a neutralizing nanobody targeting the leptin receptor at low dose adjacent to tumor decreased tumor mass with no effects on body weight or food intake. In contrast, systemic administration of the nanobody failed to suppress tumor growth. Daily intraperitoneal injection of high-dose nanobody led to weight gain, hyperphagia, increased adiposity, hyperleptinemia, and hyperinsulinemia, and central effects mimicking leptin deficiency. The blockade of central actions of leptin by systemic delivery of nanobody may compromise its anticancer effect, underscoring the need to develop peripherally acting leptin antagonists coupled with efficient cancer-targeting delivery.
Syntheses of Thieno[2,3-c]-, Pyrrolo[2,3-c]- and Indolo[2,3-c]diazanaphthalenes by Photocyclization of Acylaminopyridines (1977)

By the photocyclization of the amides derived from thiophene-2-, Nmethylpyrrole-2-, and N-methylindole-2-carboxylic acids and aminopyridines, novel palycyilic heteroaromatic systems such as thieno12, 3-c]-, pyrrolo[2,3-c]-, and indolo[2,3-cldiazanaphthalenes were synthesized.37 Structures of all the new compounds were supported by elemental analyses and their spectral (uv, ir, nmr, and mass)data.