gebhart/patrepeval huggingface dataset:
Effects of berberine hydrochloride on nonalcoholic fatty liver disease in rats (2007)

Objective To investigate the effects of berberine hydrochloride on nonalcoholic fatty liver disease in rats.Methods Forty male Wistar rats were randomly divided into control (n=10) and experimental groups (n=30).Rats in control group were fed with standard diet,and those in experimental group were fed with high-fat diet.After 12 weeks,rats in experimental group were randomly subdivided into three groups:model group (n=9),polyene phosphatidylcholine treated group (n=9) and berberine hydrochloride treated group (n=9).After 4 weeks,aspartate aminotransferase,alanine aminotransferase,fasting plasma glucose,total cholesterol,triglyceride (TG),high density lipid cholesterol and low density lipid cholesterol (LDL-C) were measured by biochemical method and insulin was measured by radioimmunoassay.Body weight,liver weight, epididymal fat,perirenal fat and total visceral fat were measured as well.Results Berberine hydrochloride treatment decreased serum aminotransferase,TG,LDL-C and insulin levels.The epididymal fat and perirenal fat in berberine hydrochloride treated group were also decreased. Furthermore,the insulin resistance and the steatosis of liver in berberine hydrochloride treated group were improved dramatically.Conclusion Berberine hydrochloride may attenuate hepatic fat degeneration of rats with fatty liver induced by high-fat diet through improving insulin resis- tance.
Future of melatonin as a therapeutic agent. (2002)

Report of the round table conference summarizing the International Symposium on "Melatonin: Clinical Significance and Therapeutic Applications" is presented in this article. Some sleep disorders and circadian rhythm disturbances are the widely accepted indications for melatonin treatment. However, other possibilities for use of melatonin in the therapy should be also taken into account, including a co-treatment in cancer patients and free radical-related diseases. All aspects of the possible therapeutic use of melatonin as well as its safety, dosage, side effects and contraindications are discussed herein based on the round table conference and they are presented in this paper.
Systematic construction, verification and implementation methodology for LDPC codes (2012)

In this article, a novel and systematic Low-density parity-check (LDPC) code construction, verification and implementation methodology is proposed. The methodology is composed by the simulated annealing based LDPC code constructor, the GPU based high-speed code selector, the ant colony optimization based pipeline scheduler and the FPGA-based hardware implementer. Compared to the traditional ways, this methodology enables us to construct both decoding-performance-aware and hardware-efficiency-aware LDPC codes in a short time. Simulation results show that the generated codes have much less cycles (length 6 cycles eliminated) and memory conflicts (75% reduction on idle clocks), while having no BER performance loss compared to WiMAX codes. Additionally, the simulation speeds up by 490 times under float precision against CPU and a net throughput 24.5 Mbps is achieved. Finally, a net throughput 1.2 Gbps (bit-throughput 2.4 Gbps) multi-mode LDPC decoder is implemented on FPGA, with completely on-the-fly configurations and less than 0.2 dB BER performance loss.
Researches on Middleware Technology (2004)

With the development of computer and network communication technology .middleware makes significant progress. There have yielded various theories of software development, standards and commercial softwares in middleware area. Middleware will act as a more important role in the development and evolvement of large-scale, network-centric systems. This paper introduces the current state of middleware, summarizes the mainstream middleware technology - Distribute Object Computing,as well as some booming technologies such as Web Services, Grid and OGSA. Then,according to the requirements of future distributed systems,we discuss the challenges which middleware technology is facing.
Transient Receptor Potential Ankyrin 1 Ion Channel Contributes to Guarding Pain and Mechanical Hypersensitivity in a Rat Model of Postoperative Pain (2012)

The TRPA1 channel in the skin contributes to sustained as well noxious mechanical stimulus-evoked postoperative pain, whereas the spinal TRPA1 channel contributes predominantly to innocuous mechanical stimulus-evoked postoperative pain.
The Distortion of Information during Decisions (1996)

During a decision might a preexisting preference lead to the distortion of new information in favor of the preferred alternative? An experiment that furnished one alternative with a prior preference found such predecisional distortion. It was also found that in the absence of any initial preference, a developing preference for one alternative led to the distortion of new information so as to favor that leading alternative. The distortion from both sources, preexisting and developing preferences, exceeded the postdecisional distortion from cognitive dissonance reduction.
Using non-steroidal anti-inflammatory drugs in the treatment of depression. (2010)

we propose a multi-centre double-blinded randomised controlled trial with two objectives: to determine whether citalopram plus celecoxib dual therapy achieves a greater reduction in depressive symptoms (quantified using the Hamilton Depression Rating Scale (HDRS)) within four weeks, compared to citalopram monotherapy; and to determine whether citalopram plus celecoxib dual therapy is more likely to achieve remission (HDRS score ?7) of moderate to severe depression within six months, compared with citalopram monotherapy. The endpoints will be the reduction in HDRS score after 4 weeks of treatment, and the HDRS score after 26 weeks of treatment. The study will enrol 452 participants from general practices who have a moderate or severe, current or recurrent major depressive episode when medication with an SSRI is considered. The study population will be stratified according to age, sex, HDRS score, age of onset of first episode, number of previous depressive episodes and duration of current episode. The population will then be randomised into two groups. Subjects will be interviewed to determine HDRS score, measure blood pressure, count pills and discuss side-effects. This will occur weekly for the first four weeks, and every four weeks thereafter.
Specific immunosuppression of experimental autoimmune myasthenia gravis by denatured acetylcholine receptor. (1978)

Specific immunosuppression of experimental autoimmune myasthenia gravis (EAMG) was achieved by the use of a denatured preparation of the acetylcholine receptor (AcChoR) that did not in itself induce the disease. Torpedo californica AcChoR was irreversibly denatured by complete reduction and carboxymethylation in 6 M guanidine hydrochloride. Rabbits immunized with reduced carboxymethylated receptor (RCM-AcChoR) produced antibodies that reacted with both RCM-AcChoR and intact AcChoR. The specificity of anti-RCM-AcChoR antibodies is different from that of anti-AcChoR antibodies because the former are directed to only part of the antigenic determinants present in the intact receptor. RCM-AcChoR, which by itself is completely nonmyasthenic, was shown to be capable of both preventing the onset of EAMG and of reversing the clinical symptoms in myasthenic rabbits. In all cases the therapeutic effect of RCM-AcChoR administration on EAMG was accompanied by a change in the immunological specificity of the antibodies. The crossreactivity between AcChoR and RCM-AcChoR and the nonpathogenicity of RCM-AcChoR appear to be crucial in governing the specific immunosuppressive effects of RCM-AcChoR on EAMG.
Management of crowdsourced first-person video (2014)

We present a framework for large-scale crowdsourcing of first-person viewpoint videos recorded on mobile devices. Collecting videos at a massive scale poses a number of major issues in terms of network planning. To improve the scalability with regards to the number of users, videos and geographical area and better cope with restrictions on storage, bandwidth and processing power, the framework is distributed and based on the two-layer cloudlet architecture. To mitigate the limited bandwidth in the access network, a set of decision algorithms is constructed and evaluated that are able to filter out irrelevant videos based on their metadata and given selection criteria. To illustrate the crowdsourcing framework, we present Street View Live, an application for presenting videos based on location, similar to the popular Google Street View but with up-to-date videos covering the location instead of possibly outdated images. In order to have an up-to-date view of every location, the video collection is continuously extended and updated by crowdsourcing videos from mobile devices.
PtrWRKY19, a novel WRKY transcription factor, contributes to the regulation of pith secondary wall formation in Populus trichocarpa (2016)

WRKY proteins are one of the largest transcription factor families in higher plants and play diverse roles in various biological processes. Previous studies have shown that some WRKY members act as negative regulators of secondary cell wall formation in pith parenchyma cells. However, the regulatory mechanism of pith secondary wall formation in tree species remains largely unknown. In this study, PtrWRKY19 encoding a homolog of Arabidopsis WRKY12 was isolated from Populus trichocarpa. PtrWRKY19 was expressed in all tissues tested, with highest expression in stems, especially in pith. PtrWRKY19 was located in the nucleus and functioned as a transcriptional repressor. Ectopic expression of PtrWRKY19 in an atwrky12 mutant successfully rescued the phenotype in pith cell walls caused by the defect of AtWRKY12, suggesting that PtrWRKY19 had conserved functions for homologous AtWRKY12. Overexpression of PtrWRKY19 in poplar plants led to a significant increase in the number of pith parenchyma cells. qRT-PCR analysis showed that lignin biosynthesis-related genes were repressed in transgenic plants. In transcient reporter assays, PtrWRKY19 was identified to repress transcription from the PtoC4H2 promoter containing the conserved W-box elements. These results indicated that PtrWRKY19 may function as a negative regulator of pith secondary wall formation in poplar.
Actin reorganization and proplatelet formation in murine megakaryocytes: the role of protein kinase Cα (2001)

With the recent cloning and characterization of thrombopoietin, appreciation of the molecular events surrounding megakaryocyte (MK) development is growing. However, the final stages of platelet formation are less well understood. Platelet production occurs after the formation of MK proplatelet processes. In a study to explore the molecular mechanisms underlying this process, mature MKs isolated from suspension murine bone marrow cell cultures were induced to form proplatelets by exposure to plasma, and the role of various cell-signaling pathways was assessed. The results showed that (1) bis-indolylmaleimide I, which blocks protein kinase C (PKC) activation; (2) down-modulation of conventional or novel classes of PKC by phorbol myristate acetate; and (3) ribozymes specific for PKCalpha each inhibited proplatelet formation. Inhibition of several MAP kinases, PI3 kinase, or protein kinase A failed to affect MK proplatelet formation. To gain further insights into the function of PKCalpha in proplatelet formation, its subcellular localization was investigated. In cultures containing active proplatelet formation, cytoplasmic polymerized actin was highly aggregated, its subcellular distribution was reorganized, and PKCalpha colocalized with the cellular actin aggregates. A number of MK manipulations, including blockade of integrin signaling with a disintegrin or inhibition of actin polymerization with cytochalasin D, interrupted actin reorganization, PKC relocalization, and proplatelet formation. These findings suggest an important role for PKCalpha in proplatelet development and suggest that it acts by altering actin dynamics in proplatelet-forming MKs. Identification of the upstream and downstream pathways involved in proplatelet formation should provide greater insights into thrombopoiesis, potentially allowing pharmacologic manipulation of the process.
Speed closed-loop control system based on general-purpose inverter (2002)

General-purpose inverters have the characteristic of low price and convenient operation. But they often need a specialized feedback card when feedback closed-loop control is demanded. This results in high cost and limited range of application. This paper considers the problem from cost and precision of constant speed aspects. The authors deal with speed-measuring conversion using an external single-chip processor. Closed-loop speed control can then be achieved in two ways. One is to utilize the process-input port of the inverter and the other is external PID. Therefore the cost of system is cut down and the range of application is expanded.
Identification of the Promoter Region of the Taka-amylase A Gene Required for Starch Induction. (1991)

which is known as Taka-amylase A (TAA), is an inducible enzyme and starch, maltose, isomaltose, and panose are effective inducers,
Device Physics and Design of a L-Shaped Germanium Source Tunneling Transistor (2012)

A novel tunneling field-effect transistor (TFET) with an L-shaped Ge source is investigated. The device comprises a Ge source that extends underneath a Si-channel region and separated from the drain by an insulator (SiO 2 ). By optimizing the overlap length of the extended source L OV and the Si body thickness T Si , the current due to vertical band-to-band tunneling (BTBT) of the Ge–Si hetero-junction could be increased significantly and is scalable with L OV . This leads to higher I ON and improved S . The SiO 2 also reduces OFF-state current I OFF by blocking leakage paths. With extensive simulation, the device physics and design guidelines of this novel structure are outlined.
ADVANCED CUTTINGS TRANSPORT STUDY (2004)

The Advanced Cuttings Transport Study (ACTS) was a 5-year JIP project undertaken at the University of Tulsa (TU). The project was sponsored by the U.S. Department of Energy (DOE) and JIP member companies. The objectives of the project were: (1) to develop and construct a new research facility that would allow three-phase (gas, liquid and cuttings) flow experiments under ambient and EPET (elevated pressure and temperature) conditions, and at different angle of inclinations and drill pipe rotation speeds; (2) to conduct experiments and develop a data base for the industry and academia; and (3) to develop mechanistic models for optimization of drilling hydraulics and cuttings transport. This project consisted of research studies, flow loop construction and instrumentation development. Following a one-year period for basic flow loop construction, a proposal was submitted by TU to the DOE for a five-year project that was organized in such a manner as to provide a logical progression of research experiments as well as additions to the basic flow loop. The flow loop additions and improvements included: (1) elevated temperature capability; (2) two-phase (gas and liquid, foam etc.) capability; (3) cuttings injection and removal system; (4) drill pipe rotation system; and (5) drilling section elevation system. In parallel with the flow loop construction, hydraulics and cuttings transport studies were preformed using drilling foams and aerated muds. In addition, hydraulics and rheology of synthetic drilling fluids were investigated. The studies were performed under ambient and EPET conditions. The effects of temperature and pressure on the hydraulics and cuttings transport were investigated. Mechanistic models were developed to predict frictional pressure loss and cuttings transport in horizontal and near-horizontal configurations. Model predictions were compared with the measured data. Predominantly, model predictions show satisfactory agreements with the measured data. As a part of this project, instrumentation was developed to monitor cuttings beds and characterize foams in the flow loop. An ultrasonic-based monitoring system was developed to measure cuttings bed thickness in the flow loop. Data acquisition software controls the system and processes the data. Two foam generating devices were designed and developed to produce foams with specified quality and texture. The devices are equipped with a bubble recognition system and an in-line viscometer to measure bubble size distribution and foam rheology, respectively. The 5-year project is completed. Future research activities will be under the umbrella of Tulsa University Drilling Research Projects. Currently the flow loop is being used for testing cuttings transport capacity of aqueous and polymer-based foams under elevated pressure and temperature conditions. Subsequently, the effect of viscous sweeps on cuttings transport under elevated pressure and temperature conditions will be investigated using the flow loop. Other projects will follow now that the ''steady state'' phase of the project has been achieved.
Morphology and Growth Mechanisms of Self-Assembled Films on Insulating Substrates: Role of Molecular Flexibility and Entropy (2017)

We studied the effect of molecular flexibility on the morphology and growth mechanisms of self-assembled films on an insulating substrate using a combination of experimental and theoretical methods. 1,3,5-Tri-(4-cyano-4,4 biphenyl)-benzene (TCB) and 1,4-bis(cyanophenyl)-2,5-bis(decyloxy) benzene (CDB) molecules were deposited on a KCl (001) surface and imaged using noncontact atomic force microscopy (NC-AFM). Both molecules were designed to contain the same anchoring groups and benzene ring structures, yet CDB self-assembled structures were observed to grow from step edges, while TCB self-assembled structures grew as islands on the clean terrace and from step edges. Density functional theory (DFT) and atomistic molecular dynamics simulations were performed to understand this qualitative difference in growth modes. Calculations of free energies of dimer formation and step adhesion provide an insight into the role played by entropy loss in the morphology and growth modes of self-assembled films.
Ruthenium(II) catalyzed rearrangement of diallyl ethers. A synthesis of .gamma.,.delta.-unsaturated aldehydes and ketones (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRuthenium(II) catalyzed rearrangement of diallyl ethers. A synthesis of .gamma.,.delta.-unsaturated aldehydes and ketonesJames M. Reuter and Robert G. SalomonCite this: J. Org. Chem. 1977, 42, 21, 3360–3364Publication Date (Print):October 1, 1977Publication History Published online1 May 2002Published inissue 1 October 1977https://pubs.acs.org/doi/10.1021/jo00441a009https://doi.org/10.1021/jo00441a009research-articleACS PublicationsRequest reuse permissionsArticle Views633Altmetric-Citations73LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Inadequate dietary intake and altered nutrition status in early HIV-1 infection. (1994)

Recent studies indicate that multiple nutritional abnormalities occur relatively early in the course of human immunodeficiency virus (HIV-1) infection. Decreased plasma levels of vitamins B6, B12, A, and E and zinc have been correlated with dietary intake and associated with significant alterations in immune response and cognitive function. To determine the level of intake consistent with normal plasma nutrient levels, we examined nutrition status in relation to food consumption and nutrient supplementation in HIV-1-seropositive (HIV+) and -seronegative (HIV-) homosexual men. The mean level of total intake (diet plus supplements) for all nutrients was significantly higher in HIV+ men. To achieve normal plasma nutrient values, the HIV+ men appeared to require intake in multiples of the recommended dietary allowance (RDA) for vitamins A, E, B6, and B12 and zinc. For the HIV+ men, a relatively high proportion of biochemical deficiency was associated with consumption of vitamin B6 and zinc at the RDA level. Because little evidence of deficiency was observed with elevated intake in both groups, an effective program of nutritional supplementation may be beneficial in maintaining adequate plasma nutrient levels.
Comparison of immunogenicity and tolerability of a virosome-adjuvanted and a split influenza vaccine in children (2004)

The virosome-adjuvanted influenza vaccine showed greater immunogenicity over the split influenza vaccine in unprimed children and showed a trend toward better immunogenicity in the rest of the study population. Both vaccines were well-tolerated.
Electrochemical Behavior of Semiconductors under Illumination (1966)

In contrast to metals, the average free energy of electrons can be changed in semiconductors to a great extent by illumination. Especially the concentration of minority electronic carriers can differ by orders of magnitude from the equilibrium value. This has two major effects on electrode processes: (a) change of charge distribution and potential drops in the space charge layer; and (b) variation of the rate of electrode reaction in which minority carriers are involved. Some examples are given for those effects at various semiconductors.
XLV.—<i>Some new and little-known Upper Cretaceous Fishes from Mount Lebanon.</i> (1942)

(1942). XLV.—Some new and little-known Upper Cretaceous Fishes from Mount Lebanon.. Annals and Magazine of Natural History: Vol. 9, No. 56, pp. 537-568.
A Low Power High Performance Multiplexed Keeper Technique (2006)

This paper presents a technique to improve the performance of wide dynamic circuits by efficiently using the conditional keeper. PMOS transistor which is used to charge the dynamic node in the precharge phase is also used as a conditional keeper in the evaluation phase. The keeper functionality is merged in precharge PMOS. It is found that at same DC noise robustness; this technique gives 9% improvement in delay, 14% improvement in power and 18% improvement in clock load compared to conditional keeper technique. Further, this technique gives zero delay penalties but higher noise immunity compared to conventional dynamic circuits.