gebhart/patrepeval huggingface dataset:
Identification of alpha-adrenergic receptors in uterine smooth muscle membranes by [3H]dihydroergocryptine binding. (1976)

[3H]Dihydroergocryptine, a potent alpha-adrenergic antagonist, was used to label smooth muscle membrane binding sites which have the characteristics expected of alpha-adrenergic receptors. Binding of [3H]dihydroergocryptine to rabbit uterine membranes was rapid and reversible with rate constants of 1.26 X 10(7) M-1 min-1 and 0.034 min-1 for the forward and reverse reactions, respectively. [3H]Dihydroergocryptine binding was of high affinity, with an equilibrium dissociation constant (KD) of 8 to 10 nM. Binding was saturable with 0.14 to 0.17 pmol of [3H]dihydroergocryptine bound/mg of protein at maximal occupancy of the sites. No cooperative interactions among the sites were detected. The specificity of the binding sites for a large number of adrenergic agonists and antagonists was identical with the specificity of alpha-adrenergic responses to these agents. The alpha-adrenergic agonist (-)-epinephrine competed for binding with a KD of 0.23 muM. The order of potencies for several adrenergic agonists in competing for the binding sites was (-)-epinephrine greater than (-)-norepinephrine greater than (-)-phenylephrine greater than (-)-isoproterenol in agreement with their alpha-adrenergic potencies. A series of 19 phenylethylamine adrenergic agonists competed for binding in a manner paralleling their potencies as alpha-adrenergic agonists. alpha-Adrenergic antagonists such as phentolamine (KD = 15 nM) and phenoxybenzamine (KD = 18 nM) potently competed for the binding sites. In contrast, beta-adrenergic antagonists such as propranolol (KD = 27,000 nM) and practolol (KD greater than 10(6) nM) did not have high affinity for the binding sites. A series of ergot alkaloids competed for [3H]dihydroergocryptine binding in a manner which paralleled their potencies as alpha-adrenergic agents. Competition for binding sites by alpha-adrenergic agonists and antagonists was a stereospecific process. The (-)-stereoi somers of epinephrine, norepinephrine, and ergotamine were at least 20- to 50-fold more potent than the corresponding (+)-stereoisomers. Compounds devoid of significant alpha-adrenergic activity, such as pyrocatechol, 3,4-dihydroxymandelic acid, normetanephrine, and D-lysergic acid, did not effectively compete for [3H]dihydroergocryptine binding sites. These rabbit uterine binding sites for [3H]dihydroergocryptine appear to have characteristics indistinguishable from those of the physiologically active alpha-adrenergic receptors.
Monolithically Integrated Diode Laser Detection System for Scanning Near-Field Optical Microscopy (SNOM) : VCSEL Technology (1999)

International audience
Sulfur-Tolerant Materials for the Hydrogen Sulfide SOFC (2004)

This study examined sulfur tolerant materials for solid oxide fuel cells (SOFCs) operating on and containing fuels, focusing on the stability and electrochemical performance of perovskite-type materials in a atmosphere under SOFC operating conditions atm, Preliminary results indicate anodes of the general form are stable and active toward the electrochemical oxidation of In particular, an SOFC using as the anode has shown good performance at levels of 10%, over 5000 times greater than the tolerance level of contemporary Ni-based systems. The results are promising due to the drastic improvement in sulfur tolerance compared to the current generation of SOFC anode materials. © 2004 The Electrochemical Society. All rights reserved.
Automated Discovery of WordNet Relations (1998)

The WordNet lexical database is now quite large and offers broad coverage of general lexical relations in English. As is evident in this volume, WordNet has been employed as a resource for many applications in natural language processing (NLP) and information retrieval (IR). However, many potentially useful lexical relations are currently missing from WordNet. Some of these relations, while useful for NLP and IR applications, are not necessarily appropriate for a general, domain-independent lexical database. For example, WordNet’s coverage of proper nouns is rather sparse, but proper nouns are often very important in application tasks. The standard way lexicographers find new relations is to look through huge lists of concordance lines. However, culling through long lists of concordance lines can be a rather daunting task (Church and Hanks, 1990), so a method that picks out those lines that are very likely to hold relations of interest should be an improvement over more traditional techniques. This chapter describes a method for the automatic discovery of WordNetstyle lexico-semantic relations by searching for corresponding lexico-syntactic patterns in large text collections. Large text corpora are now widely available, and can be viewed as vast resources from which to mine lexical, syntactic, and semantic information. This idea is reminiscent of what is known as “data mining” in the artificial intelligence literature (Fayyad and Uthurusamy, 1996), however, in this case the ore is raw text rather than tables of numerical data. The Lexico-Syntactic Pattern Extraction (LSPE) method is meant to be useful as an automated or semi-automated aid for lexicographers and builders of domain-dependent knowledge-bases. The LSPE technique is light-weight; it does not require a knowledge base or complex interpretation modules in order to suggest new WordNet relations.
A topology processor that tracks network modifications (1988)

Software considerations and test results are given for a topology processor that can track the changes in the network over time. It is expected that by knowing the changes from one cycle to the next, certain steps in the network solution can be avoided or replaced with steps requiring significantly less computation. The steps of particular interest are the ordering and factoring of the network solution matrix. In the operator training simulator, where solution time is critical, the simulation computation slows down when changes take place in the network, but the presented topology processor may provide the means to keep up with real time. In the security analysis real-time time sequence, computation can be saved in the state estimator if its tracking topology processor is used. The use of this topology processor modifies the solution of the tracking mode. For large topology changes, it is the same as the conventional tracking mode. But for the more common small topology changes, the matrices are not rebuilt and considerable computation time is saved.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Defining the Role of the Escherichia coli Chaperone SecB Using Comparative Proteomics (2005)

To improve understanding and identify novel substrates of the cytoplasmic chaperone SecB in Escherichia coli, we analyzed a secB null mutant using comparative proteomics. The secB null mutation did not affect cell growth but caused significant differences at the proteome level. In the absence of SecB, dynamic protein aggregates containing predominantly secretory proteins accumulated in the cytoplasm. Unprocessed secretory proteins were detected in radiolabeled whole cell lysates. Furthermore, the assembly of a large fraction of the outer membrane proteome was slowed down, whereas its steady state composition was hardly affected. In response to aggregation and delayed sorting of secretory proteins, cytoplasmic chaperones DnaK, GroEL/ES, ClpB, IbpA/B, and HslU were up-regulated severalfold, most likely to stabilize secretory proteins during their delayed translocation and/or rescue aggregated secretory proteins. The SecB/A dependence of 12 secretory proteins affected by the secB null mutation (DegP, FhuA, FkpA, OmpT, OmpX, OppA, TolB, TolC, YbgF, YcgK, YgiW, and YncE) was confirmed by "classical" pulse-labeling experiments. Our study more than triples the number of known SecB-dependent secretory proteins and shows that the primary role of SecB is to facilitate the targeting of secretory proteins to the Sec-translocase.
Accumulation of advanced glycation end products as a molecular mechanism for aging as a risk factor in osteoarthritis (2004)

These findings demonstrate increased severity of OA at higher cartilage AGE levels and provide the first in vivo experimental evidence for a molecular mechanism by which aging may predispose to the development of OA.
Control of Wavelength Dispersion of Birefringence for Oriented Copolycarbonate Films Containing Positive and Negative Birefringent Units (2003)

The wavelength dispersion of birefringence for uniaxially oriented copolycarbonate films containing positive and negative birefringent units has been examined by polarization-modulated transmission spectro-ellipsometry, as a function of copolymerization ratio and stretching parameters. The copolymers were synthesized from 2,2-bis(4-hydroxyphenyl)propane (BPA), 9,9-bis(4-hydroxy-3-methylphenyl)fluorene (BMPF) and phosgene by interfacial polycondensation. The films indicate reverse dispersion in the region of BMPF volume fraction from 0.65 to 0.80. The wavelength dispersion is controlled by the copolymerization ratio. The dispersion change of the 70 mol% BMPF copolycarbonate films as a function of stretching parameters is negligible. These behaviors are explained by the birefringence equation for a multicomponent system of the copolymer.
COMPLICATIONS OF GASTROINTESTINAL ENDOSCOPY (2006)

Gastrointestinal (GI) endoscopy has now been part of conventional medical practice for over thirty years following the development of useable flexible fibreoptic endoscopes in the early 1970’s. Initially just used for diagnostic examination of the upper GI tract with biopsies, the technique was initially extended to the lower GI tract and then began the expansion of therapeutic techniques which continues to the present time. Although using natural portals and not needing to cross tissue planes to gain access, this new technology was nevertheless invasive of the human body and so, like all invasive techniques, accompanied by attendant risks and complications. Sedation-related complications predominated in the early days but the expansion of therapeutic endoscopy dramatically widened the scope for complications. The potential benefits of therapeutic endoscopy need to be weighed against the potential to do harm. Two large audits of UK endoscopic practice (References 2 and 3 ‐ Cardio-pulmonary and Sedation-related Complications) have shown a surprisingly high incidence of both morbidity and mortality following upper and lower GI diagnostic and therapeutic endoscopy. More recently, the National Confidential Enquiry into Post-operative deaths (NCEPOD) report into therapeutic GI endoscopy has also found further prima facie evidence of suboptimal endoscopic practice.
The virtual reality modeling language and Java (1998)

article Free Access Share on The virtual reality modeling language and Java Author: Don Brutzman Naval Postgraduate School, Monterey, CA; and VRML Consortium Naval Postgraduate School, Monterey, CA; and VRML ConsortiumView Profile Authors Info & Claims Communications of the ACMVolume 41Issue 6June 1998pp 57–64https://doi.org/10.1145/276609.276620Published:01 June 1998Publication History 68citation1,446DownloadsMetricsTotal Citations68Total Downloads1,446Last 12 Months163Last 6 weeks24 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Intrathecal Baclofen for Spasticity Management in Rett Syndrome (2003)

Intrathecal baclofen infusions have proven to be effective for management of spasticity during the last two decades. Efficacy of intrathecal baclofen for spasticity of spinal origin has been well established and has shown promise in treatment of spasticity that is not spinal in origin. Rett syndrome is a neurodevelopmental disorder primarily affecting girls and women. Manifested in the advanced stages of this syndrome is increased spasticity leading to functional decline. Presented is a case report of a 32-yr-old white woman with Rett syndrome, diagnosed before the age of 2 yr, and significant spasticity that was successfully managed with intrathecal baclofen. After placement of an intrathecal baclofen pump, the dose was increased slowly during 1 yr to 800 microg/day with good clinical response. There was observed a significant decrease in upper and lower limb Ashworth scores, from an average of 3-4 to 2-3, during this 1-yr period. The decrease in spasticity in this patient eventually led to improved range of motion, positioning, skin care, hygiene, and quality of life. Intrathecal baclofen is an effective option in managing severe spasticity from Rett syndrome.
Synthesis of Ester Derivatives of Brominated Poly(isobutylene-<i>c</i><i>o</i>-isoprene):  Solvent-Free Phase Transfer Catalysis (2006)

The principles of phase transfer catalysis (PTC) are adapted to facilitate solvent-free nucleophlic substitution reactions of brominated poly(isobutylene-co-isoprene) (BIIR). Catalytic amounts of tetraalkylammonium halides are shown to activate alkali metal carboxylate salts to generate ester derivatives in moderate to high yields without incurring complications associated with ammonium carboxylate salt instability and BIIR dehydrobromination. The structures of a range of new aliphatic and aromatic allylic esters are characterized unambiguously through comparisons with products derived from brominated 2,2,4,8,8-pentamethyl-4-nonene (BPMN), which serves as a model for the reactive functionality found within BIIR. The dynamics of the intrinsic substitution process are examined along with factors that affect the rate and selectivity of phase-partitioned, solvent-free PTC systems.
Variable temperature apparatus using a thermal conductivity measurement technique for the determination of superconducting ac power loss (1975)

A variable temperature apparatus is described which uses a thermal conductivity measurement technique for the determination of superconducting ac power loss. The technique consists of measuring the increase in temperature of a thermally isolated sample carrying an alternating current. Accurate measurements over a relatively large temperature range are possible. Loss data on a 13 cm long, single filament NbTi superconductor are presented at various temperatures and currents.
Simultaneous 2D Strain Sensing Using Polymer Planar Bragg Gratings (2015)

We demonstrate the application of polymer planar Bragg gratings for multi-axial strain sensing and particularly highlight simultaneous 2D strain measurement. A polymer planar Bragg grating (PPBG) fabricated with a single writing step in bulk polymethylmethacrylate is used for measuring both tensile and compressive strain at various angles. It is shown that the sensitivity of the PPBG strongly depends on the angle between the optical waveguide into which the grating is inscribed and the direction along which the mechanical load is applied. Additionally, a 2D PPBG fabricated by writing two Bragg gratings angularly displaced from each other into a single polymer platelet is bonded to a stainless steel plate. The two reflected wavelengths exhibit different sensitivities while tested toward tensile and compressive strain. These characteristics make 2D PPBG suitable for measuring multi-axial tensile and compressive strain.
Is measles infection associated with Crohn's disease? (1998)

Is measles infection associated with Crohn's disease?The current evidence does not prove a causal link
The Distributed Data-Mining Worksho (1999)

The Workshop on Distributed Data Mining (DDM), held at the Fourth International Conference on Knowledge Discovery and Data Mining, brought interested researchers and practitioners together and created an environment for crystallizing the fast-growing field of DDM. The workshop focused on the state-of-the-art DDM algorithms, systems, and application-related issues.
Development of CAFV System for the Gas Dynamics (1987)

CAFV(Computer Aided Flow Visualization) system for the gas dynamics has been developed. The flow field is visualized using LIF of I 2 seeded in Ar and monitered by high sensitive vidicon camera. Image data from vidicon camera at many different visualized planes are stored up in personal computer in order to estimate three-dimensional information on the entire flow field. For the purpose of removing the noise, one frame data is accumulated many times and averaged. This system is applied to two flow fields, i.e., the free jet expanding into a vacuum chamber and the interacting flow field between a skimmer and the free jet. The contour lines of fluorescence intensity on each flow field are depicted effectively.
Occurrence and taxonomic characteristics of strains of predominant in African indigenous fermented foods and beverages (2003)

Indigenous fermented foods and beverages play a major role in the diet of African people. The predominant yeast species seen is Saccharomyces cerevisiae, involved in basically three groups of indigenous fermented products: non-alcoholic starchy foods, alcoholic beverages and fermented milk. These products are to a great extent made by spontaneous fermentation and consequently S. cerevisiae often coexists with other microorganisms even though a microbiological succession usually takes place both between and within species. The functions of S. cerevisiae are mainly related to formation of alcohols and other aroma compounds, but stimulation of e.g. lactic acid bacteria, improvement of nutritional value, probiotic effects, inhibition of undesired microorganisms and production of tissue-degrading enzymes may also be observed. Several different isolates of S. cerevisiae have been shown to be involved in the fermentations and some of the isolates show pheno- and genotypic characteristics that deviate from those normally recognised for S. cerevisiae.
Foreword (1959)

Journal Article Foreword Get access V.T. WILLIAMS V.T. WILLIAMS Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Experimental Botany, Volume 10, Issue 2, June 1959, Pages 155–156, https://doi.org/10.1093/jxb/10.2.155 Published: 01 June 1959
An RNA aptamer perturbs heat shock transcription factor activity in Drosophila melanogaster (2011)

Heat shock transcription factor (HSF1) is a conserved master regulator that orchestrates the protection of normal cells from stress. However, HSF1 also protects abnormal cells and is required for carcinogenesis. Here, we generate an highly specific RNA aptamer (iaRNA(HSF1)) that binds Drosophila HSF1 and inhibits HSF1 binding to DNA. In Drosophila animals, iaRNA(HSF1) reduces normal Hsp83 levels and promotes developmental abnormalities, mimicking the spectrum of phenotypes that occur when Hsp83 activity is reduced. The HSF1 aptamer also effectively suppresses the abnormal growth phenotypes induced by constitutively active forms of the EGF receptor and Raf oncoproteins. Our results indicate that HSF1 contributes toward the morphological development of animal traits by controlling the expression of molecular chaperones under normal growth conditions. Additionally, our study demonstrates the utility of the RNA aptamer technology as a promising chemical genetic approach to investigate biological mechanisms, including cancer and for identifying effective drug targets in vivo.
Zn<sup>2+</sup> entry produces oxidative neuronal necrosis in cortical cell cultures (1999)

Evidence has accumulated that Zn2+ plays a central role in neurodegenerative processes following brain injuries including ischaemia or epilepsy. In the present study, we examined patterns and possible mechanisms of Zn2+ neurotoxicity. Inclusion of 30-300 microM Zn2+ for 30 min caused neuronal necrosis apparent by cell body and mitochondrial swelling in cortical cell cultures. This Zn2+ neurotoxicity was not attenuated by antiapoptosis agents, inhibitors of protein synthesis or caspase. Blockade of glutamate receptors or nitric oxide synthase showed no beneficial effect against Zn2+ neurotoxicity. Interestingly, antioxidants, trolox or SKF38393, attenuated Zn(2+)-induced neuronal necrosis. Pretreatment with insulin or brain-derived neurotrophic factor increased the Zn(2+)-induced free radical injury. Kainate or AMPA facilitated Zn2+ entry and potentiated Zn2+ neurotoxicity in a way sensitive to trolox. Reactive oxygen species and lipid peroxidation were generated in the early phase of Zn2+ neurotoxicity. These findings indicate that entry and accumulation of Zn2+ result in generation of toxic free radicals and then cause necrotic neuronal degeneration under certain pathological conditions in the brain.
T-Cell Responses and Immunity to Experimental Infection with Leishmania Major (1989)

Exhausted CD8 T (Tex) cells are a distinct cell lineage that arise during chronic infections and cancers in animal models and humans. Tex cells are characterized by progressive loss of effector functions, high and sustained inhibitory receptor expression, ...Read More
Fast inversion recovery magnetic resonance angiography of the intracranial arteries (2010)

Inversion-prepared pulse sequences can be used for noncontrast MR angiography (MRA) but suffer from long scan times when acquired using conventional nonaccelerated techniques. This work proposes a subtraction-based spin-labeling, three-dimensional fast inversion recovery MRA (FIR-MRA) method for imaging the intracranial arteries. FIR-MRA uses alternating cycles of nonselective and slab-selective inversions, leading to dark-blood and bright-blood images, respectively. The signal difference between these images eliminates static background tissue and generates the angiogram. To reduce scan time, segmented fast gradient recalled echo readout and parallel imaging are applied. The inversion recovery with embedded self-calibration method used allows for parallel acceleration at factors of 2 and above. An off-resonance selective inversion provides effective venous suppression, with no detriment to the depiction of arteries. FIR-MRA was compared against conventional three-dimensional time-of-flight angiography at 3 T in eight normal subjects. Results showed that FIR-MRA had superior vessel conspicuity in the distal vessels (P < 0.05), and equal or better vessel continuity and venous suppression. However, FIR-MRA had inferior vessel sharpness (P < 0.05) in four of nine vessel groups. The clinical utility of FIR-MRA was demonstrated in three MRA patients.
Implementing a Built-In Self-Test PLA Design (1985)

An NMOS implementation of a new built-in self-test PLA design is presented. The layouts for its additional test circuitry result in appoximately 15-percent overhead for most large PlAS, a significantly better overhead than that of any existing scheme. Both the input test patterns and the output responses, which are compressed intoastring of parity bits, are independent of the functions that the PLA realizes, and the 15-percent overhead includes the storage needed for the fault-free compressed output data. The fault coverage of this approach consists of all single and (1-2 -( 2n + m)) of all multiple stuck, crosspoint, and bridging faults in the original PLA and the additional test circuitry (n and m are the number of input variables and product terms, respectively). The article begins with a short review of existing design schemes.