gebhart/patrepeval huggingface dataset:
Binding of the hypoxia tracer [3H]misonidazole in cerebral ischemia. (1987)

Radiolabelled misonidazole, a radiosensitizing drug that binds to viable hypoxic tumor cells, may be useful in identifying hypoxic cells in cerebrovascular disease. Its potential was investigated in the gerbil stroke model. Biodistribution of [3H]misonidazole was measured in normal gerbils and animals that had been subjected to right common carotid artery ligation to produce cerebral ischemia. The uptake of [3H]misonidazole in the right cerebral hemisphere and right/left hemispheral uptake ratios correlated positively with the severity of the stroke when measured 6-9 hours after carotid ligation. Histologic studies in symptomatic ligated animals showed ipsilateral widespread but patchy acute ischemic changes as well as areas that showed no morphological changes. Microscopic autoradiography in these animals showed diffuse heavy labelling only in the ipsilateral hemisphere. This was over areas that had histological damage as well as in adjacent areas that appeared intact. Studies comparing blood flow measur...
Hemodynamic Effects of Bosentan, an Endothelin Receptor Antagonist, in Patients With Pulmonary Hypertension (2000)

Intravenous bosentan is a potent but nonselective pulmonary vasodilator at the doses tested, even in patients resistant to inhaled nitric oxide. Transient increases in plasma ET-1 were observed, consistent with a blockade of endothelial ET(B) receptors. Systemic hypotension and other significant events during the study indicate that its intravenous use in patients with severe PHT may be limited. Implications for future trial design and studies of chronic oral treatment are discussed.
Hybrid Multiplexing of Multiband Optical Access Technologies Towards an Integrated DWDM Network (2006)

A hybrid multiplexing scheme with the capability to multiplex optical millimeter-wave, baseband, and intermediate frequency signals is proposed and demonstrated. The proposed scheme enables the convergence of "last mile" wireless and wireline technologies, leading to an integrated dense wavelength-division multiplexed network in the access and metro domain
Measurement of Factor H Variants in Plasma Using Variant-Specific Monoclonal Antibodies: Application to Assessing Risk of Age-Related Macular Degeneration (2008)

The novel monoclonal antibody MBI-7 was used to develop a robust assay for measurement of fH and the variants in plasma. The simplicity of the assay means that it may be used by any clinical laboratory to identify polymorphic status and to quantify plasma levels in persons at risk for AMD.
Great Migrations. By Georges Blond. Translated from the French by A. H. Brodrick. Hutchinson of London. 16<i>s</i>. (1959)

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Sparse nonnegative matrix approximation: new formulations and algorithms (2010)

We introduce several new formulations for sparse nonnegative matrix approximation. Subsequently, we solve these formulations by developing generic algorithms. Further, to help selecting a particular sparse formulation, we briefly discuss the interpretation of each formulation. Finally, preliminary experiments are presented to illustrate the behavior of our formulations and algorithms.
Textile Pressure Sensor Made of Flexible Plastic Optical Fibers (2008)

In this paper we report the successful development of pressure sensitive textile prototypes based on flexible optical fibers technology. Our approach is based on thermoplastic silicone fibers, which can be integrated into woven textiles. As soon as pressure at a certain area of the textile is applied to these fibers they change their cross section reversibly, due to their elastomeric character, and a simultaneous change in transmitted light intensity can be detected. We have successfully manufactured two different woven samples with fibers of 0.51 and 0.98 mm diameter in warp and weft direction, forming a pressure sensitive matrix. Determining their physical behavior when a force is applied shows that pressure measurements are feasible. Their usable working range is between 0 and 30 N. Small drifts in the range of 0.2 to 4.6%, over 25 load cycles, could be measured. Finally, a sensor array of 2 x 2 optical fibers was tested for sensitivity, spatial resolution and light coupling between fibers at intersections.
A novel die bonding adhesive-silver filled film (2002)

Silver paste is the die bonding adhesive most widely used to attach semiconductor silicon chips to metal lead frames in plastic packages. However the increased integration of semiconductor devices and size-expansion of chips has led to the emergence a number of problems with the current adhesives, one of which is insufficient resistance to package cracking during reflow soldering. We have developed therefore a die bonding adhesive film to address these issues. Study of relations between adhesive film composition and those properties resulted in the composition featuring high peel strength and low moisture absorption. A novel die bonding adhesive-silver filled film DF-335-was capable of attaching at low temperature, low pressure and short time. This film showed excellent resistance to package cracking during reflow soldering.
Vacuum microbalance investigations on heterogeneous surface reaction mechanisms (1974)

A vacuum apparatus including a microbalance and a gas-inlet system was designed. The microbalance had two symmetric reaction tubes which were heated with temperature-controlled furnaces. A cooling trap was built into the tubes above the furnaces to freeze out the reaction products. Thus, the thermodynamical equilibrium of the reaction and the reflection of the products from the tubewalls was avoided and the kinetics of the reaction could be studied. With the totally symmetric design, thermodiffusion of the reaction gas and other disturbances caused by thermal gasflow were minimized. Electrostatic effects were suppressed by a special grounding device inside the reaction tubes. The reduction of zinc oxide powder, pellets, and single crystals with carbon monoxide and hydrogen was studied in the temperature range of 450–950 °C and pressure range from 10−2 to 5 Torr.
Yet Another Hierarchical State Machine (2004)

Most of you are probably familiar with state machines. Finite state machines (FSMs) are widely used in both digital electronics and programming. Applications include communication protocols, industrial control or GUI programming. UML includes a more flexible variant in the form of statechart diagrams. Here, states can contain other states, making the corresponding state machine hierarchical. Hierarchical state machines (HSMs) can be converted to ordinary (flat) state machines, so most implementors concentrate on the implementation of FSMs, and many implementations exist. The conversion however tends to lose the original structure of the HSM, making it difficult to make the connection between a statechart and its implementation. Clearly, it would be nicer if the HSM could be implemented directly in source code. Direct implementations of HSMs seem to be comparatively rarely published. Miro Samek provides a prominent example in his book [1]. See the sidebar (next page) for some more information about his approach, which provided the motivation for the approach I will present here. UML tools are available that generate source code directly from statechart diagrams (example: Rhapsody [5]). More information about HSMs and Statecharts can be found in [1],[2],[3] and – of course – through
Knowledge Management System for Emergency Preparedness: An Action Research Study (2006)

This paper is about the design and implementation of an information system, using Wiki technology to improve the emergency preparedness efforts of the Claremont University Consortium. For some organizations, as in this case, responding to a crisis situation in done within a consortia environment. Managing knowledge across the various entities involved in such efforts is critical. This includes having the right set of information that is timely, relevant, and is governed by an effective communication process. Our study suggests that training in use of system(s), a knowledge sharing culture between entities involved in emergency preparedness, and a fit between task and technology/system must be there to support emergency preparedness activities given such structures.
Growth, Water Relations, and Ion Content of Field-grown Celery [Apium graveolens L. var. dulce (Mill.) Pers.] under Saline Irrigation (2003)

We irrigated field-grown celery (Apium graveolens L. var. dulce [Mill.] Pers. ' Tall Utah') with four concentrations of saline water, NSC (nonstressed control), SW1, SW2, and SW3, corresponding to EC of 0.5, 4.4, 8.5, and 15.7 dS·m -1 , respectively, plus a nonirrigated control (NIC) and investigated the effects of the treatments on water relations, yield and ion content. In addition, we compared simultaneously plant response to both salt and drought stress by using a modified version of the threshold-slope model. Increasing salinity of the irrigation water reduced fresh and dry weights of the shoots, but increased the dry matter percentage in shoots. The marketable yield was moderately affected by salinity (25% reduction at EC 8.5 dS·m -1 ). In contrast, a severe water stress dramatically decreased the marketable yield from 23 t·ha -1 (average of the irrigated treatments) to <7 t·ha -1 (nonirrigated control). Na + and Cl - concentrations increased in salinized plants whereas nitrogen content, K + , Ca 2+ , and Mg 2+ concentrations decreased upon salinization. Midday leaf water potentials (Ψ t ) decreased from -1.48 MPa (0.5 dS·m -1 ) to -2.05 MPa (15.7 dS·m -1 ) and - 2.17 MPa (nonirrigated control), though the reduction in leaf cellular turgor was less severe. The maintenance of high leaf cellular turgor was positively correlated to a decrease in osmotic potential and to an increased bulk modulus of elasticity. These results indicate that it is possible to irrigate celery with saline water (up to 8.5 dS·m -1 ) with acceptable losses in marketable yield and confirmed that in the field, this species has the ability to efficiently regulate water and ion homeostasis. In the absence of irrigation, celery plants were unable to cope with the drought stress experienced, although this was comparable, in terms of soil water potential, to the one caused by saline irrigation.
Oxidized and Aggregated Recombinant Human Interferon Beta is Immunogenic in Human Interferon Beta Transgenic Mice (2011)

Oxidation-mediated aggregation increased the immunogenicity of rhIFNβ-1a in transgenic mice, whereas aggregated preparations devoid of measurable oxidation levels were hardly immunogenic.
Positioning and the specific sequence of each 13‐mer motif are critical for activity of the plasmid RK2 replication origin (2005)

The minimal replication origin of the broad-host-range plasmid RK2, oriV, contains five iterons which are binding sites for the plasmid-encoded replication initiation protein TrfA, four DnaA boxes, which bind the host DnaA protein, and an AT-rich region containing four 13-mer sequences. In this study, 26 mutants with altered sequence and/or spacing of 13-mer motifs have been constructed and analysed for replication activity in vivo and in vitro. The data show that the replacement of oriV 13-mers by similar but not identical 13-mer sequences from Escherichia coli oriC inactivates the origin. In addition, interchanging the positions of the oriV 13-mers results in greatly reduced activity. Mutants with T/A substitutions are also inactive. Furthermore, introduction of single-nucleotide substitutions demonstrates very restricted sequence requirements depending on the 13-mer position. Only two of the mutants are host specific, functional in Pseudomonas aeruginosa but not in E. coli. Our experiments demonstrate considerable complexity in the plasmid AT-rich region architecture required for functionality. It is evident that low internal stability of this region is not the only feature contributing to origin activity. Our studies suggest a requirement for sequence-specific protein interactions within the 13-mers during assembly of replication complexes at the plasmid origin.
The human tyrosine kinase gene (FER) maps to chromosome 5 and is deleted in myeloid leukemias with a del(5q) (1990)

A novel member of the SRC tyrosine kinase gene family was recently isolated and characterized (Hao et al., 1989). This FES/FPS-related gene, named FER, lacks the transmembrane and extracellular domains which characterize tyrosine kinases with receptor function. Expression of FER in a wide range of cell types indicates a general role in intracellular signalling or differentiation processes. We have now mapped FER to chromosome 5q14----q23 using in situ hybridization techniques and suggest a more precise location within bands 5q21----q22. This region lies adjacent to a complex domain of growth factors and receptors, many involved in regulation of haematopoiesis. FER maps within a critical segment frequently deleted from chromosome 5 in patients with acute myeloid leukemia or myelodysplastic syndromes and was shown to be deleted in two such patients. It also maps close to the familial polyposis coli locus at 5q22.
The smartcard as a mobile security device (2002)

Modern society would like to replace paper by electronic data carriers and mechanical processes by electronic processes. Smartcards offer one means to this end in the form of a personal mobile security device. Personal data can be stored in a mobile personal environment instead of in a central database, and processor smartcards additionally provide a sort of pocket PC that can perform security functions at a higher level of security than an ordinary PC. Interoperability of different smartcards with different smartcard readers and data terminals is very important; therefore, standards exist for the structure of data objects on the card and for coding the commands sent to the card. Biometric user-authentication is becoming increasingly important for smartcards as an alternative to the previously used PIN or password authentication. Additional convenience for the user can be provided by contactless cards.
Outsourcing Security Analysis with Anonymized Logs (2006)

As security monitoring grows both more complicated and more sophisticated, there is an increased demand for outsourcing these tasks to managed security service providers (MSSPs). However, the core problem of sharing private security logs creates a barrier to the widespread adoption of this business model. In this paper we analyze the logs used for security analysis with the concern of privacy and propose the constraints on anonymization of security monitor logs. We believe if the anonymization solution fulfills the constraints, MSSPs can detect the attacks efficiently and protect privacy simultaneously
Analysis of the ATM protein in wild-type and ataxia telangiectasia cells. (1996)

Ataxia telangiectasia (A-T) is a human disorder that results in a number of clinical symptoms, including cerebellar degeneration and increased cancer predisposition. Recently the gene that is defective in A-T has been cloned and designated ATM. Here, we describe the production of antisera raised against the approximately 350 kDa ATM protein. Antisera specificity is confirmed by them recognising a approximately 350 kDa polypeptide in wild-type cells but not in A-T cells containing mutations that truncate ATM upstream of the antibody binding sites. We show that ATM is almost exclusively nuclear and is expressed in all cell lines and tissues analysed. However, ATM levels are not regulated in response to u.v. or ionising radiation. These data are consistent with ATM being a component of the DNA damage detection apparatus rather than being an inducible downstream effector of the DNA damage response. In addition, we analyse ATM protein expression in a variety of A-T patients. Strikingly, ATM expression is reduced drastically or absent in all patients analysed, including those predicted to express proteins that should be detected by our antisera. Thus, the A-T phenotype may result not only from mutations that disrupt functional domains of ATM, but also from mutations that destabilise the ATM mRNA or protein. Finally, we report that a group of patients displaying an intermediate A-T phenotype express low levels of apparently full-length ATM. This suggests that the ATM pathway is partially active in these individuals and that there is a correlation between levels of residual ATM expression and disease severity.
Punchthrough type GTO with buffer layer and homogeneous low efficiency anode structure (2002)

A new type of full scale 4.5 kV/3 kA GTO has been developed, fabricated, and electrically characterized. The device utilizes a punchthrough concept with a buffer layer. To avoid the requirement of excessive gate currents for turn-on, the new GTO has a homogeneous anode layer without shorts. The anode has a very low efficiency, which allows efficient extraction of charge during turn-off. With the buffer layer, the new device has a significantly reduced wafer thickness as compared to conventional devices without buffer. This reduces switching as well as on-state losses. The turn-off losses of the best devices were reduced to one third of those of conventional GTOs and, at the same time, the on-state losses were decreased by more than one third.
Design of a fine alignment system featuring active orientation adjustment for nano imprint lithography (2014)

The fine alignment between a template with nano patterns and a wafer substrate, especially the parallelism between the two surfaces, is critical to Nano Imprint Lithography. A fine alignment system featuring active orientation adjustment which is composed of an imprint unit and a 6-DOF micromanipulator is proposed in this work. Deformations of a compact flexure layer caused by imprint loads are measured by four identical force sensors embedded in the imprint unit. The tilt of the flexure layer can thus be eliminated by adjusting the orientation of the 6-DOF micromanipulator. Kinematics and stiffness analysis are then developed, followed by dynamic performance evaluations. Based on the proposed system, an imprint tool is further developed and corresponding experiments are conducted. A saw shape grating pattern with 1.6 μm linewidth and a lattice pattern with 0.9 μm period are both imprinted with a minimum feature of 30 nm well reserved on the substrate. A maximum parallelism error of 14 nm across the template surface is also demonstrated by further section analyses on the imprinted patterns, hence the feasibility and superiority of the proposed method is verified.
Slot Line Components for Millimeter Wave and Sub-Millimeter Wave Integrated Circuits (1988)

Measurements of radiation losses from a few slot line components on high-epsilon (around 11) materials are presented, including short circuits, open circuits, and lambda-quarter filters. Also covered are losses via surface modes, and tapered slot antenna radiation patterns. Measured wavelengths are given for slot lines on substrates of dielectric constants 10.5 and 11. A wideband slot line to microstrip transition is presented.
Partition Coefficients for Acetic, Propionic, and Butyric Acids in a Crude Oil/Water System (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPartition Coefficients for Acetic, Propionic, and Butyric Acids in a Crude Oil/Water SystemMark A. Reinsel, John J. Borkowski, and John T. SearsCite this: J. Chem. Eng. Data 1994, 39, 3, 513–516Publication Date (Print):July 1, 1994Publication History Published online1 May 2002Published inissue 1 July 1994https://pubs.acs.org/doi/10.1021/je00015a026https://doi.org/10.1021/je00015a026research-articleACS PublicationsRequest reuse permissionsArticle Views1276Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Non-primate Lentiviral Vector Administration in the TMJ (2004)

Gene therapy is emerging as a novel treatment method for the management of temporomandibular joint disorders. The aim of this investigation was to study the effects of lentiviral vectors on the temporomandibular joint. Consequently, we injected into the articular joint space a defective feline immunodeficiency virus capable of infecting dividing as well as terminally differentiated cells with the reporter gene lacZ, the expression of which was studied by means of PCR, X-gal histochemistry, and beta-galactosidase immunocytochemistry. Our results showed successful transduction of hard and soft tissues of the temporomandibular joint. Interestingly, a subset of primary sensory neurons of the ipsilateral trigeminal ganglion also stained positive for the reporter gene, presumably following uptake of the lentiviral vector by peripheral nerve fibers and retrograde transport to the nucleus. These findings suggest that lentiviral vectors can potentially serve as a platform for the transfer of anti-nociceptive genes for the management of temporomandibular joint pain.
Greater than the sum of their parts: CD-ROM/online hybrids (1996)

Presentation du 1996 Grolier Multimedia Encyclopedia, un CD-ROM qui comprend eviron 12 000 liens avec le service en ligne CompuServe, ces liens permettent a l'utilisateur du CD-ROM de se retrouver en reseau et donc d'avoir acces a des forums, des publications electroniques, des services de nouveautes, des bases de donnees et a des causeries sur les sujets sur lesquels portaient leur recherche sur CD-ROM. L'evolution de ces produits hybrides est donc analysee, puis les systemes hybrides a destination des professionnels de l'information sont presentes, ainsi que ceux pour les consommateurs particluliers
[Biological functions and the practical use of chitin]. (1984)

The review is dedicated to chitin--a wide-spread in nature polyaminosaccharide. Its main physico-chemical properties and biological role in the cell are analyzed. The review centres round the practical use of chitin and its derivatives. Natural resources, modern modes for production and application of chitin and its derivatives in industry, medicine, biotechnology and agriculture are discussed.