gebhart/patrepeval huggingface dataset:
Physicochemical properties and <i>N</i>-terminal sequence of eel lectin (1984)

Some physicochemical properties of the L-fucose-binding lectin from the serum of the European eel (Anguilla anguilla) were determined. The lectin is a dimer composed of identical subunits of Mr approx. 40000. In agreement with previous results [Horejsí & Kocourek (1978) Biochim. Biophys. Acta 538, 299-315], the subunit was shown to comprise two non-glycosylated polypeptides of Mr approx. 20000 and linked by disulphide bonds. N-Terminal sequence analysis, carboxypeptidase digestion and peptide mapping indicated identity of the polypeptides. There were two L-fucose-binding sites per subunit with KD 1.6 X 10(-3) M for the lectin-fucose complex, as determined by equilibrium dialysis.
Reactions of halocarbonyls of Group VIb elements. II. Complexes of molybdenum and tungsten containing group Va donors or phenyl isocyanide (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions of halocarbonyls of Group VIb elements. II. Complexes of molybdenum and tungsten containing group Va donors or phenyl isocyanideAlan D. Westland and Naftali MuriithiCite this: Inorg. Chem. 1973, 12, 10, 2356–2361Publication Date (Print):October 1, 1973Publication History Published online1 May 2002Published inissue 1 October 1973https://pubs.acs.org/doi/10.1021/ic50128a028https://doi.org/10.1021/ic50128a028research-articleACS PublicationsRequest reuse permissionsArticle Views293Altmetric-Citations73LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
[Stress lesions in gymnasts (author's transl)]. (1978)

In this paper, rate dependent evolution laws are identified and characterized to model the mechanical (elasticity-based) and thermal damage occurring in coarse grain refractory material subject to cyclic thermal shock. The interacting mechanisms for elastic deformation driven damage induced by temperature gradients and thermal damage induced by isotropic thermal expansion are combined and represented by a single variable for the total damage. The constitutive model includes the shielding of micro-structural thermal damage by the non-local elasticity-based damage developed at the macroscopic and microscopic scale. Quasi-stationary thermal experiments are used to identify the parameters used in the evolution law for thermal damage. The remaining model parameters, including a micro-structural length scale, are quantified by inverse modelling of cyclic thermal shock experiments. Longitudinal wave propagation measurements through damaged material are simulated, enabling the identification on the basis of the first and second thermal shock cycle. A third thermal shock cycle enabled the evaluation of the quality of the obtained parameter set. The set-up of the thermal shock experiments has been optimized through a parameter identifiability analysis. The damage evolution in three consecutive thermal shock cycles is investigated numerically with the optimized model.
The Solubility of Some Sparingly Soluble Salts of Zinc and Cadmium in Water and in Aqueous Electrolyte Solutions (1992)

The literature on the solubility of the sparingly soluble inorganic salts of zinc and cadmium in water and in aqueous electrolyte solutions has been reviewed. The solubility data have been compiled and evaluated. Recommended or tentative values of the solubilities and the solubility products have been given when warrented. Auxiliary thermodynamic and crystallographic data useful in the interpretation of solubility data are given. For the many zinc and cadmium substances for which only limited solubility data are available, unevaluated values are given in an annotated bibliography with emphasis on solubility data published since 1950.
Review: Role of Transforming Growth Factor Beta (TGFβ) in Systemic Autoimmunity (1993)

Transforming growth factor (TGF beta) is a multifunctional cytokine with proinflammatory as well as immunosuppressive activities. A regulatory role for TGF beta has been suggested in investigations of several experimental and spontaneous models of pathological autoreactivity. It is suggested that many of the functional effects of TGF beta parallel the major immune system abnormalities seen in SLE.
UV light inactivation of Cryptosporidium oocysts (1998)

Animal infectivity studies demonstrate the efficacy of pulsed and advanced UV in inactivating Cryptosporidium oocysts. Cryptosporidium parvum oocysts are highly resistant to conventional chlorine‐based disinfectants. The authors tested two innovative electrotechnologies that use ultraviolet (UV) light and found that both pulsed UV and advanced UV inactivated Cryptosporidium oocysts. The advanced UV system achieved >4‐log inactivation as determined in animal infectivity studies using the neonatal mouse model. With the pulsed UV system, oocyst inactivation was also noted in the process control (non‐UV‐exposed oocysts), suggesting that some oocyst inactivation may have occurred independently of UV exposure. Irrespective of this, both technologies appear to be effective and novel ways to treat drinking water and to provide an additional significant barrier that helps protect public health.
Affinity cleavage and targeted catalysis of proteins using the avidin-biotin system (1990)

The avidin-biotin system was used in order to target enzymes to their substrates in complex mixtures of proteins in solution. The approach described here thus mimics natural systems in which enzymes usually act in selective fashion, due, perhaps, to proximity effects. For affinity cleavage studies, biotinyl transferrin was used as a model target substrate. Avidin or streptavidin was then employed to bridge between the biotinylated target protein and a biotinyl protease. Bovine serum albumin was included in the reaction mixtures to assess the level of nonspecific cleavage. In the case of an unbiotinylated target protein, avidin could be used to inhibit the hydrolytic action of the biotinyl protease. In some systems, a biotinyl antibody could be used to direct the avidin-bridged biotinyl protease to an unbiotinylated target antigen. The data support the contention that preferential cleavage reflects two separate phenomena: (i) avidin confers a conformational alteration of the biotinylated target protein, and (ii) the biotinyl protease is targeted (via the avidin bridge) to the proximity of the biotinylated target protein, thereby promoting cleavage of the conformationally altered molecule. This is the first report in which a proteolytic enzyme could be selectively targeted to specifically hydrolyze a defined protein substrate in solutions containing a complex mixture of other proteins. The approach appears to be a general phenomenon for "targeted catalysis", appropriate for other applications, particularly for affinity cleavage and targeted catalysis of cell-based macromolecules.
Transcriptional Activation of the Telomerase hTERT Gene by Human Papillomavirus Type 16 E6 Oncoprotein (2001)

The E6 and E7 oncogenes of human papillomavirus type 16 (HPV-16) are sufficient for the immortalization of human genital keratinocytes in vitro. The products of these viral genes associate with p53 and pRb tumor suppressor proteins, respectively, and interfere with their normal growth-regulatory functions. The HPV-16 E6 protein has also been shown to increase the telomerase enzyme activity in primary epithelial cells by an unknown mechanism. We report here that a study using reverse transcription-PCR and RNase protection assays in transduced primary human foreskin keratinocytes (HFKs) shows that the E6 gene (but not the E7 gene) increases telomerase hTERT gene transcription coordinately with E6-induced telomerase activity. In these same cells, the E6 gene induces a 6.5-fold increase in the activity of a 1,165-bp 5' promoter/regulatory region of the hTERT gene, and this induction is attributable to a minimal 251-bp sequence (-211 to +40). Furthermore, there is a 35-bp region (+5 to +40) within this minimal E6-responsive promoter that is responsible for 60% of E6 activity. Although the minimal hTERT promoter contains Myc-responsive E-box elements and recent studies have suggested a role for Myc protein in hTERT transcriptional control, we found no alterations in the abundance of either c-Myc or c-Mad in E6-transduced HFKs, suggesting that there are other or additional transcription factors critical for regulating hTERT expression.
Implementation of a cellular framework for spontaneous network establishment (2005)

Wireless communication technologies enabled the possibility of building spontaneous networks between two or more users to exchange data. The problem in the establishment of such networks lies in the configuration that has to be agreed on and in the way the communicating parties can be identified. In prior publications we have presented our vision of convenient networking in a heterogeneous environment. In this paper, we describe an implementation that offers a dashboard-like tool, which can, with the help of a cellular network, ease the formation of spontaneous networks among heterogeneous nodes. Furthermore, the provided implementation is able to secure the acquired communication links in the spontaneous network and therefore protect the exchanged information against possible abuse.
Autoreactive T Cells in Multiple Sclerosis (1992)

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) characterized by infiltration of T lymphocytes and macrophages into white matter leading to demyelination [1-2]. This pathology is frequently associated with disability of neurological function, in particular sensory deficits, visual problems and paralysis. The acute MS plaques are markered by the presence of activated T cells expressing the IL-2 receptor as well as activated, class II MHC positive macrophages [3-4]. In addition, cytokines such as TNF and oligoclonal immunoglobulin have been found in the brain and cerebrospinal fluid (CSF) of patients with MS [5-7]. This active inflammatory process is confined to the CNS, not affecting either the peripheral nervous system or other organs. Although it is generally accepted that this CNS inflammatory process causes demyelination and the resulting neurologic disability in MS, the mechanism(s) by which the inflammation is initiated and maintained is unknown.
Blood vessel classification into arteries and veins in retinal images (2007)

The prevalence of diabetes is expected to increase dramatically in coming years; already today it accounts for a major proportion of the health care budget in many countries. Diabetic Retinopathy (DR), a micro vascular complication very often seen in diabetes patients, is the most common cause of visual loss in working age population of developed countries today. Since the possibility of slowing or even stopping the progress of this disease depends on the early detection of DR, an automatic analysis of fundus images would be of great help to the ophthalmologist due to the small size of the symptoms and the large number of patients. An important symptom for DR are abnormally wide veins leading to an unusually low ratio of the average diameter of arteries to veins (AVR). There are also other diseases like high blood pressure or diseases of the pancreas with one symptom being an abnormal AVR value. To determine it, a classification of vessels as arteries or veins is indispensable. As to our knowledge despite the importance there have only been two approaches to vessel classification yet. Therefore we propose an improved method. We compare two feature extraction methods and two classification methods based on support vector machines and neural networks. Given a hand-segmentation of vessels our approach achieves 95.32% correctly classified vessel pixels. This value decreases by 10% on average, if the result of a segmentation algorithm is used as basis for the classification.
Robotic endoscope motor module and gearing design (2011)

Actuation of a robotic endoscope with increased torque output is presented. This paper will specifically focus on the motor module section of a robotic endoscope, which comprises of a pair of motors and gear reduction assemblies. The results for the endoscope and biopsy tool stiffness, as well as the stall force and force versus speed characteristics of the motor module assembly are shown. The scope stiffness was found to be 0.006 N/degree and additional stiffness of the biopsy tools were found to be in the range of 0.09 to 0.13 N/degree. Calculations for worm gearing and efficiency are discussed.
Video Prediction with Appearance and Motion Conditions (2018)

Video prediction aims to generate realistic future frames by learning dynamic visual patterns. One fundamental challenge is to deal with future uncertainty: How should a model behave when there are multiple correct, equally probable future? We propose an Appearance-Motion Conditional GAN to address this challenge. We provide appearance and motion information as conditions that specify how the future may look like, reducing the level of uncertainty. Our model consists of a generator, two discriminators taking charge of appearance and motion pathways, and a perceptual ranking module that encourages videos of similar conditions to look similar. To train our model, we develop a novel conditioning scheme that consists of different combinations of appearance and motion conditions. We evaluate our model using facial expression and human action datasets and report favorable results compared to existing methods.
Preparation and photocatalytic activity of titanate nanorods (2008)

Titanate nanorods have been synthesized by means of a simple hydrothermal method,and then calcined at 400,500,600 and 800℃ for 2h,respectively.The as-prepared products were characterized by XRD,SEM,TEM,BET and UV-vis spectrum.The photocatalytic activities of the titanate nanorods were tested by the photocatalytic degradation of 4-chloronitrobenzene(4-CNB).Results indicate that the titanate nanorods possess high heat stability with a diameter of about 50-150nm,and have a length up to a few micrometers.Photodegradation results show that the degradation of 4-CNB fit first-order kinetics,titanate nanorods calcined at 500℃ exhibit the highest photocatalytic activity,and the apparent rate constant is 0.04215min-1,which is twice more than that of commercial TiO2 powder.
Synthesis of Xanthene Derivatives having Antispasmodic Action.V : Alkamine Esters of Chloroxanthene-9-acetic Acids (1966)

1-Chloroxanthen-9-ol (IIIa) was prepared by the reduction of 1-chloroxanthen-9-one (IIa) with sodium amalgam and ethanol. IIIa was condensed with malonic acid to 1-chloroxanthene-9-malonic acid (IVa), and the acid was decarboxylated to 1-chloroxanthene-9-acetic acid (Va). Cyclization of l-(m-chlorophenoxy)benzoic acid (XI) afforded a mixture (IIa') of IIa and 3-chloroxanthen-9-one, and IIa was not isolated. Therefore, IIa was prepared from 1-amino-xanthen-9-one. (Ia). 2-, 3-, and 4-Chloroxanthene-9-acetic acids (Vb-d) were prepared and their alkamine ester hydrochlorides were obtained. The anti-acetylcholine, anti-barium chloride, and anti-histamine activities of Va∼d these ester hydrochlorides were examined and it was found that the introduction of chlorine into the xanthene ring of the alkamine ester hydrochlorides of xanthene-9-acetic acid, especially into the 2-or 3-position resulted in the weakening of these activities.
CURSO DE TEATRO (1965)

DARA INICIO EL CURSO SOBRE CRITICA TEATRAL QUE SE IMPARTE EN EL CENTRO UNIVERSITARIO DE TEATRO. LOS CURSOS QUE SE IMPARTIRAN SON LOS SIGUIENTES: FUNDAMENTOS DE LA CRITICA POR EL DOCTOR RICARDO GUERRA, EL LENGUAJE DE LA CRITICA POR LA MAESTRA MARGO GLANTZ, EL CRITICO TEATRAL POR EL MAESTRO FAUSTO CASTILLO, CRITICA Y PSICOANALISIS POR EL DOCTOR VICTOR MANUEL AIZA, ENTRE OTROS. EL CICLO DURARA DEL 8 DE FEBRERO AL 14 DE ABRIL.
Immediate and early loading of Straumann implants with a chemically modified surface (SLActive) in the posterior mandible and maxilla: 1‐year results from a prospective multicenter study (2008)

The results demonstrated that Straumann implants with the SLActive surface are safe and predictable when used in immediate and early loading procedures. Even in poor-quality bone, survival rates were comparable with those from conventional or delayed loading. The mean bone-level change was not deemed to be clinically significant and compared well with the typical bone resorption observed in conventional implant loading.
Functionalized Nanoporous Silica for the Removal of Heavy Metals from Biological Systems: Adsorption and Application (2010)

Surface-functionalized nanoporous silica, often referred to as self-assembled monolayers on mesoporous supports (SAMMS), has previously demonstrated the ability to serve as very effective heavy metal sorbents in a range of aquatic and environmental systems, suggesting that they may be advantageously utilized for biomedical applications such as chelation therapy. Herein we evaluate surface chemistries for heavy metal capture from biological fluids, various facets of the materials' biocompatibility, and the suitability of these materials as potential therapeutics. Of the materials tested, thiol-functionalized SAMMS proved most capable of removing selected heavy metals from biological solutions (i.e., blood, urine, etc.) Consequentially, thiol-functionalized SAMMS was further analyzed to assess the material's performance under a number of different biologically relevant conditions (i.e., variable pH and ionic strength) to gauge any potentially negative effects resulting from interaction with the sorbent, such as cellular toxicity or the removal of essential minerals. Additionally, cellular uptake studies demonstrated no cell membrane permeation by the silica-based materials generally highlighting their ability to remain cellularly inert and thus nontoxic. The results show that organic ligand functionalized nanoporous silica could be a valuable material for a range of detoxification therapies and potentially other biomedical applications.
Hybrid web service composition (2004)

Over the last few years several process-based web service composition languages have erged, such as BPEL4WS and BPML. These languages define the composition on the basis of a process that specifies the control and data flow among the services to be composed. In this approach, the whole business logic underlying the composition including business policies and constraints is coded as a monolithic block. As a result, business rules are hard to change without affecting the core composition logic.
Improved Coiled-Coil Design Enhances Interaction with Bcr-Abl and Induces Apoptosis (2011)

The oncoprotein Bcr-Abl drives aberrant downstream activity through trans-autophosphorylation of homo-oligomers in chronic myelogenous leukemia (CML).(1, 2) The formation of Bcr-Abl oligomers is achieved through the coiled-coil domain at the N-terminus of Bcr.(3, 4) We have previously reported a modified version of this coiled-coil domain, CCmut2, which exhibits disruption of Bcr-Abl oligomeric complexes and results in decreased proliferation of CML cells and induction of apoptosis.(5) A major contributing factor to these enhanced capabilities is the destabilization of the CCmut2 homodimers, increasing the availability to interact with and inhibit Bcr-Abl. Here, we included an additional mutation (K39E) that could in turn further destabilize the mutant homodimer. Incorporation of this modification into CCmut2 (C38A, S41R, L45D, E48R, Q60E) generated what we termed CCmut3, and resulted in further improvements in the binding properties with the wild-type coiled-coil domain representative of Bcr-Abl [corrected]. A separate construct containing one revert mutation, CCmut4, did not demonstrate improved oligomeric properties and indicated the importance of the L45D mutation. CCmut3 demonstrated improved oligomerization via a two-hybrid assay as well as through colocalization studies, in addition to showing similar biologic activity as CCmut2. The improved binding between CCmut3 and the Bcr-Abl coiled-coil may be used to redirect Bcr-Abl to alternative subcellular locations with interesting therapeutic implications.
Diagnosis and Treatment of Leishmaniasis: Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA) and the American Society of Tropical Medicine and Hygiene (ASTMH) (2016)

It is important to realize that leishmaniasis guidelines cannot always account for individual variation among patients. They are not intended to supplant physician judgment with respect to particular patients or special clinical situations. The IDSA and ASTMH consider adherence to these guidelines to be voluntary, with the ultimate determinations regarding their application to be made by the physician in the light of each patient's individual circumstances.
Early Insulin Therapy in Very-Low-Birth-Weight Infants (2008)

Early insulin therapy offers little clinical benefit in very-low-birth-weight infants. It reduces hyperglycemia but may increase hypoglycemia (Current Controlled Trials number, ISRCTN78428828.)
Acne vulgaris, I: pathogenesis and diagnosis. (2002)

Acne vulgaris is a chronic inflammatory disease of the pilosebaceous units. It is a pleomorphic disorder with multifactorial pathogenesis. The many expressions of acne rarely present a diagnostic challenge, but correct classification of acne is crucial in choosing the appropriate therapies. Although previous research has provided a better understanding of the pathogenic factors, there is still a great deal to be learned.
Passively synchronized dual-wavelength Q-switched lasers (2005)

We present a simple and efficient way of generating synchronized Q-switched pulses at wavelengths hundreds of nanometers apart. This principle can result in new pulsed all-solid-state light sources at new wavelengths based on SFG.
Effective Computer Aided Instruction in Biomedical Science (1985)

A menu-driven Computer Aided Instruction (CAI) package was integrated with word processing and effectively applied in five curricula at the Medical College of Wisconsin. Integration with word processing facilitates the ease of CAI development by instructors and was found to be the most important step in the development of CAI. CAI modules were developed and are currently used to reinforce lectures in medical pathology, laboratory quality control, computer programming and basic science reviews of medicine. Modules help the lecturer efficiently cover fundamentals and provide the student with a self-directed learning alternative. A structured approach to CAI has helped build a CAI program which supports other traditional modes of instruction at MCW.