gebhart/patrepeval huggingface dataset:
Iodinin (1,6-Dihydroxyphenazine 5,10-Dioxide) from Streptosporangium sp. Induces Apoptosis Selectively in Myeloid Leukemia Cell Lines and Patient Cells (2013)

Despite recent improvement in therapy, acute myeloid leukemia (AML) is still associated with high lethality. In the presented study, we analyzed the bioactive compound iodinin (1,6-dihydroxyphenazine 5,10-dioxide) from a marine actinomycetes bacterium for the ability to induce cell death in a range of cell types. Iodinin showed selective toxicity to AML and acute promyelocytic (APL) leukemia cells, with EC50 values for cell death up to 40 times lower for leukemia cells when compared with normal cells. Iodinin also successfully induced cell death in patient-derived leukemia cells or cell lines with features associated with poor prognostic such as FLT3 internal tandem duplications or mutated/deficient p53. The cell death had typical apoptotic morphology, and activation of apoptotic signaling proteins like caspase-3. Molecular modeling suggested that iodinin could intercalate between bases in the DNA in a way similar to the anti-cancer drug daunorubicin (DNR), causing DNA-strand breaks. Iodinin induced apoptosis in several therapy-resistant AML-patient blasts, but to a low degree in peripheral blood leukocytes, and in contrast to DNR, not in rat cardiomyoblasts. The low activity towards normal cell types that are usually affected by anti-leukemia therapy suggests that iodinin and related compounds represent promising structures in the development of anti-cancer therapy.
Multiple chemical sensitivity syndrome. (1998)

Multiple chemical sensitivity (MCS) is a syndrome in which multiple symptoms reportedly occur with low-level chemical exposure. Several theories have been advanced to explain the cause of MCS, including allergy, toxic effects and neurobiologic sensitization. There is insufficient scientific evidence to confirm a relationship between any of these possible causes and symptoms. Patients with MCS have high rates of depression, anxiety and somatoform disorders, but it is unclear if a causal relationship or merely an association exists between MCS and psychiatric problems. Physicians should compassionately evaluate and care for patients who have this distressing condition, while avoiding the use of unproven, expensive or potentially harmful tests and treatments. The first goal of management is to establish an effective physician-patient relationship. The patient's efforts to return to work and to a normal social life should be encouraged and supported.
INVESTIGATION OF SURFACE LEAKY LONGITUDINAL WAVES ON LITHIUM (1997)

This paper focuses on studies of surface leaky longitudinal waves (SLLWs) on LiNbO3 substrates. The theoretical results of searching SLLWs on LiNbO3 in the range of Euler angles (0, p, 904 and (a, O, 00) are presented, which shows the velocity can be up to 6700 to 7300ds nearly twice that of normal SAW and has attenuation in the order of 1 04dB/h, however very low piezoelectric coupling coefficient (no more than 0.14%) in the range of Euler angles(O, p, 90). The theoretical results also show that SLL W S, in the range of Euler angles (a, O', 00) of LiNb03, have phase velocities 6500 to 70OOrds and relatively high piezoelectric coupling coefficient (up to 0.6%). The experimental results at the Euler angles(O, 38, 90') and (16, 0, 0 ) On Limo3 are also shown in this paper.
Transcriptional Regulation of Chorionic Gonadotropin<i>α</i>- and<i>β</i>-Subunit Gene Expression by 8-Bromo-Adenosine 3′,5′-Monophosphate* (1986)

In placental explants and cell lines, cAMP stimulates the biosynthesis of CG alpha- and beta-subunits and produces marked stimulation of CG secretion. We investigated the effect of a cell-permeable analog, 8-bromo-cAMP (8-Br-cAMP), on CG alpha- and beta-subunit gene expression in the JEG-3 placental cell line. RNA blot hybridization analysis demonstrated that 8-Br-cAMP increased CG alpha and beta mRNA levels 15- to 30-fold, consistent with 8-Br-cAMP regulation of CG biosynthesis at a pretranslational level. Transcription rates for CG alpha- and beta-subunit genes were determined in the absence and presence of 8-Br-cAMP using nuclear run-on assays. The basal transcription rates for the alpha- and beta-subunit genes were similar and increased 4- to 6-fold after treatment with 8-Br-cAMP. Expression of chimeric genes, consisting of alpha gene [1.5 kilobase (Kb)] or CG beta gene (0.3 Kb) 5'-flanking sequences ligated to the coding sequence of a reporter enzyme chloramphenicol acetyl transferase (CAT), was used to analyze the mechanism of 8-Br-cAMP stimulation of gene transcription. A 1.5-kb segment of the alpha- gene 5'-flanking sequence was expressed efficiently in JEG-3 cells and contains both cell-specific enhancers and cAMP response elements. Basal expression of the CG beta CAT reporter gene was not observed in either JEG-3 cells or HeLa cells, and expression was not stimulated by 8-Br-cAMP. The regulatory response elements of the CG beta gene must reside in sequences outside the 0.3-kb 5'-flanking region of the CG beta gene.
Analysis of Approaches to High Density Optical Data Storage (2004)

With the development of optical data storage technology, how to improve storage density has been paid much attention to. Using the method of channel analysis, the factors and parameters influencing optical storage density are discussed, and it is concluded that the resolution of the optical system and the storage mechanism are two most important factors. In order to realize high density storage, either the resolution is improved through shorter wavelength, larger numerical aperture, super resolution and adding one more recording dimensions, or storage mechanism by decreasing recording spots and multiplexing recording spots.
Genomic Biomarkers Correlate with HLA-Identical Renal Transplant Tolerance (2013)

The ability to achieve immunologic tolerance after transplantation is a therapeutic goal. Here, we report interim results from an ongoing trial of tolerance in HLA-identical sibling renal transplantation. The immunosuppressive regimen included alemtuzumab induction, donor hematopoietic stem cells, tacrolimus/mycophenolate immunosuppression converted to sirolimus, and complete drug withdrawal by 24 months post-transplantation. Recipients were considered tolerant if they had normal biopsies and renal function after an additional 12 months without immunosuppression. Of the 20 recipients enrolled, 10 had at least 36 months of follow-up after transplantation. Five of these 10 recipients had immunosuppression successfully withdrawn for 16-36 months (tolerant), 2 had disease recurrence, and 3 had subclinical rejection in protocol biopsies (nontolerant). Microchimerism disappeared after 1 year, and CD4(+)CD25(high)CD127(-)FOXP3(+) regulatory T cells and CD19(+)IgD/M(+)CD27(-) B cells were increased through 5 years post-transplantation in both tolerant and nontolerant recipients. Immune/inflammatory gene expression pathways in the peripheral blood and urine, however, were differentially downregulated between tolerant and nontolerant recipients. In summary, interim results from this trial of tolerance in HLA-identical renal transplantation suggest that predictive genomic biomarkers, but not immunoregulatory phenotyping, may be able to discriminate tolerant from nontolerant patients.
Exploiting the loss-frequency relationship using RF communication in Underwater communication networks (2009)

This paper presents detailed description of the graphical relationship between propagation characteristics of electromagnetic waves; skin depth, total path loss and frequency for different values of distance and conductivity of the water medium for the purpose of Underwater communication. The main challenge of this type of communication is how far we can communicate without much degradation of main signal strength. Radio frequency is one of the means, which can be used for signal transmission purposes most sophistically. Major factor of this communication system is loss of RF energy due to the propagation of waves in water medium. Mainly path loss depends on transmission distance, signal frequency & conductivity of the medium. Finally our analysis shows that optimum propagation distance under water can be achieved by proper selection of the signal frequency.
The Misunderstood Gene (2001)

At a time when the complete human genome has been sequenced and when seemingly every week feature news stories describe genes that may be responsible for personality, intelligence, even happiness, Michel Morange gives us a book that demystifies the power of modern genetics. This text takes us on an easily comprehensible tour of the most recent findings in molecular biology to show us how - and if - genes contribute to biological processes and complex human behaviors. As Morange explains, if molecular biologists had to designate one category of molecules as essential to life, it would be proteins and their multiple functions, not DNA and Genes are the centerpiece of modern biology because they can be modified. But they are only the memory that life invented so that proteins could be efficiently reproduced. Morange shows us that there is far more richness and meaning in the structure and interactions of proteins than in all the theoretical speculations on the role of The book makes it clear that do not have to choose between rigid genetic determinism and fearful rejection of any specific role for genes in development or behaviour. Both are true, but at different levels of organization. Morange agrees with those who say we are not in our genes. But he also wants us to understand that are not without our genes, either. We are going to have to make do with them, and this book shows us how.
Valued constraint satisfaction problems : hard and easy problems (1995)

In order to deal with over-constrained Constraint Satisfaction Problems, various extensions of the CSP framework have been considered by taking into account costs, uncertainties, preferences, priorities... Each extension uses a specific mathematical operator (+,max...) to aggregate constraint violations. In this paper, we consider a simple algebraic framework, related to Partial Constraint Satisfaction, which subsumes most of these proposals and use it to characterize existing proposals in terms of rationality and computational complexity. We exhibit simple relationships between these proposals, try to extend some traditional CSP algorithms and prove that some of these extensions may be computationally expensive.
Dental Caries (1975)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), emerged in China in December 2019 and quickly spread around the globe, killing more than 4 million people and causing a severe economic crisis. ...Read More
Anal Sphincter Dysfunction in Parkinson's Disease (1989)

Striated anal sphincter function was studied electrophysiologically and radiologically in six patients with Parkinson's disease and chronic constipation. In five cases, there was paradoxic anal sphincter muscle contraction during simulated defecation straining resembling anismus-type pelvic outlet obstruction. Radiologic studies showed functional improvement of the defecatory mechanism following the administration of the dopamine receptor agonist apomorphine in four patients. Dysfunction of the striated anal sphincter musculature may be a significant cause of constipation in some parkinsonian patients, occurring as part of the generalized extrapyramidal motor disorder.
Cardioprotective Effects of 20(S)-Ginsenoside Rh2 against Doxorubicin-Induced Cardiotoxicity<i>In Vitro</i>and<i>In Vivo</i> (2012)

Doxorubicin (DOX) is considered as one of the best antineoplastic agents. However, its clinical use is restricted by its associated cardiotoxicity, which is mediated by the production of reactive oxygen species. In this study, 20(S)-ginsenoside Rh2 (Rh2) was explored whether it had protective effects against DOX-induced cardiotoxicity. In vitro study on H9C2 cell line, as well as in vivo investigation in one mouse and one rat model of DOX-induced cardiomyopathy, was carried out. The results showed that pretreatment with Rh2 significantly increased the viability of DOX-injured H9C2 cells. In the mouse model, Rh2 could suppress the DOX-induced release of the cardiac enzymes into serum and improved the occurred pathological changes through ameliorating the decreased antioxidant biomolecules and the cumulated lipid peroxidation malondialdehyde in heart tissues. In the rat model, Rh2 could attenuate the change of ECG resulting from DOX administration. Furthermore, Rh2 enhanced the antitumor activity of DOX in A549 cells. Our findings thus demonstrated that Rh2 pretreatment could effectively alleviate heart injury induced by DOX, and Rh2 might act as a novel protective agent in the clinical usefulness of DOX.
Phosphate is an inhibitor of copper-zinc superoxide dismutase (1984)

The superoxide dismutase (SOD) activity of bovine copper-zinc superoxide dismutase (Cu,Zn-SOD) in 50 mM Hepes [4-(2-hydroxyethyl)-1- piperazineethanesulfonic acid], pH 7.4, was decreased by approximately 50% when the solution was made 10 mM in phosphate, in spite of the fact that the ionic strength of both solutions was adjusted to be equal. A similar experiment was carried out with bovine Cu,Zn-SOD chemically modified at Arg-141 with phenylglyoxal, which consequently had approximately 20% of the activity of the unmodified protein. (This activity was shown not to be due to residual unmodified protein.) Addition of 10 mM phosphate to solutions of the modified protein caused only a small decrease (less than 5%) in the SOD activity. The presence of phosphate also caused the affinity of Cu,Zn-SOD for binding azide or cyanide anions to be reduced; this effect of phosphate was also much less for the arginine-modified protein. We conclude that the inhibitory effect of phosphate on bovine Cu,Zn-SOD is due primarily to the neutralization of the positive charge on the side chain of Arg-141. The effect of increasing ionic strength on the activities of the native and arginine-modified proteins was also investigated. We found that at high concentrations of phosphate (greater than or equal to 10 mM), the SOD activities of native and arginine-modified Cu,Zn-SOD were inhibited comparably when the ionic strength was increased. This effect is presumably due to the lysine residues near the active site.(ABSTRACT TRUNCATED AT 250 WORDS)
THE ROLE OF DIMETHYL SULPHOXIDE REDUCTASE IN THE FORMATION OF DIMETHYL SULPHIDE DURING FERMENTATIONS (1981)

The ability to produce dimethyl sulphide (DMS) during fermentation of wort is apparently a general characteristic of Saccheromyces cerevisiae and Saccharomyces uvarum. Washed suspensions of these yeasts reduce dimethyl sulphoxide (DMSO) but there is no correlation between DMS formation in fermentation and DMSO reduction in whole cells. Although different strains vary widely in their ability to reduce DMSO they all contain similar levels of NADPH—dependent DMSO reductase. This enzyme is a multi-protein system which closely resembles methionine sulphoxide reductase. Spoilage bacteria including Enterobacter cloacae can reduce DMSO more efficiently than can yeast probably because a different enzyme system is involved.
Bacteriostatic effectiveness of 1-acyl-3-(3,4-dichlorophenyl)ureas (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBacteriostatic effectiveness of 1-acyl-3-(3,4-dichlorophenyl)ureasMoneeb H. Zakaria and David TaberCite this: J. Med. Chem. 1969, 12, 4, 707–708Publication Date (Print):July 1, 1969Publication History Published online1 May 2002Published inissue 1 July 1969https://pubs.acs.org/doi/10.1021/jm00304a041https://doi.org/10.1021/jm00304a041research-articleACS PublicationsRequest reuse permissionsArticle Views30Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The vascularity and remodelling of subchondrial bone and calcified cartilage in adult human femoral and humeral heads. An age- and stress-related phenomenon (1977)

A quantitative study of the vascularity and a qualitative study of the remodelling of the calcified cartilage and subchondral bone end-plate of adult human femoral and humeral heads were performed with respect to age. In the femoral head the number of vessels per unit area was found to fall 20% from adolescence until the seventh decade and in the humeral head 15% until the sixth decade. Thereafter an increase was noted in the femur but none in the humerus. More vessels were present at all ages in the more loaded areas of the articular surfaces: 25% more for the femur and 15% more for the humerus. The degree of active remodelling by endochondral ossification declined 50% from adolescence until the seventh decade in the femoral head, and 30% until the sixth decade in the humeral head, rising thereafter to levels comparable to those found at young ages. More remodeling was noted in the more loaded areas at all ages.
The Bacillus subtilis lipoprotein LpIA causes cell lysis when expressed in Escherichia coli (1994)

A gene called lplA (lipoprotein-like) has been isolated from a genomic library of Bacillus subtilis expressed in Escherichia coli. Clones carrying the lplA gene were selected by the ability of the colonies to give visible haloes of starch hydrolysis. The cloned fragment contains an open reading frame (ORF) of 1509 bp encoding a protein of 56 kDa. The protein contains a typical N-terminal signal sequence, a putative transmembrane anchor domain and a leucine zipper at the C-terminus. The expression of this protein in E. coli causes cell lysis, only the N-terminal domain of the LplA protein being responsible for this phenotype. The mechanism of cell lysis is similar to that previously suggested for the expression in E. coli of the lipoproteins encoded by the Streptococcus pneumoniae genes malX and amiA. The protein is modified with palmitic acid when secreted in E. coli, confirming that it is a typical lipoprotein.
Applications of the Radiation from Fast Electron Beams (1951)

The radiation from fast electron beams passing through a succession of electric or magnetic fields of alternating polarity is examined. The radiation of maximum frequency is emitted in the forward direction. If the deflecting fields are not too large, a semiqualitative argument shows that the maximum frequency is the lowest possible harmonic. The frequencies emitted are determined by studying the Doppler effect, and the angular distribution of radiated energy as well as the total radiation are calculated in a simple straight-forward manner with reference to well-known formulas of special relativity. The question of the coherence of the radiation is discussed. The spectral distribution of radiated energy is then calculated more exactly. It is concluded that several applications of the radiation appear possible. A scheme for obtaining millimeter-waves of considerable power is outlined. The upper limit of the power in a band extending down to a wave-length of 1 millimeter is calculated to be of the order of several kilowatts for a beam of one ampere and an energy of 1.5 megavolt. The use of the radiation for speed monitoring of beams with energies up to 1000 megavolt is discussed.
Translational inhibition of α-synuclein by Posiphen normalizes distal colon motility in transgenic Parkinson mice. (2019)

Parkinson disease (PD) is a neurodegenerative disease with motor as well as non-motor symptoms, including gastrointestinal dysfunction. In humans, these precede the motor symptoms by decades. Previously developed and characterized transgenic mice expressing the mutant human α-synuclein gene (<i>SNCA</i>) (either A53T or A30P), but not the endogenous mouse <i>Snca</i>, serve as models for familial PD. These animals demonstrate both robust abnormalities in enteric nervous system (ENS) function as well as synuclein-immunoreactive aggregates in ENS ganglia by 3 months of age, recapitulating early gastrointestinal abnormalities seen before the gait impairment characteristics of human and murine PD. Posiphen is a translational inhibitor of α-synuclein that targets the 5' untranslated region (UTR) of <i>SNCA</i> mRNA and could be a potential drug for the treatment of PD. However, its efficacy in ameliorating symptoms of PD has not yet been evaluated. Here, we used these transgenic mouse models to investigate the efficacy of Posiphen in reversing the gastrointestinal dysfunction. We show that Posiphen normalizes the colonic motility of both transgenic mouse models, although it did not affect the Whole Gut Transit Time (WGTT). Pharmacokinetics studies revealed that Posiphen is more abundant in the brain than in blood, in agreement with its lipophilicity, and the main metabolite is N<sup>8</sup>-NorPosiphen, a molecule with similar properties as Posiphen. The brain Posiphen levels necessary to effect optimal function were calculated and compared with efficacious brain levels from previous studies, showing that a 2-3 mM concentration of Posiphen and metabolites is sufficient for functional efficacy. Finally, 10 mg/kg Posiphen reduced α-synuclein levels in the gut of <i>hSNCA<sup>A53T</sup></i> mice treated for twenty-one weeks, while 50 and 65 mg/kg Posiphen reduced α-synuclein levels in the brain of <i>hSNCA<sup>A53T</sup></i> mice treated for twenty-one days. In conclusion, this is the first study showing the preclinical efficacy of Posiphen in normalizing the colonic motility in mouse models of gastrointestinal dysfunction in early PD. This result is in agreement with the ability of Posiphen to reach the nervous system, and its mechanism of action, the translational inhibition of α-synuclein expression. These significant findings support further development of Posiphen as a drug for the treatment of PD.
Development of a Standard Coiled-Tubing Fatigue Test (1993)

Abstract The understanding and modelling of coiled tubing (CT) fatigue life has continued to be a major area of concern as CT diameters have increased, usage and variety of applications continue to grow, and tubing is subjected to higher pressures. This paper presents a method and testing apparatus which has been developed in an attempt to simplify and standardize CT fatigue testing. Preliminary results from this testing method are compared with full-scale tests and a fatigue life prediction model to demonstrate that this method is valid.
Low-Bending-Loss and Low-Splice-Loss Single-Mode Fibers Employing a Trench Index Profile (2005)

A single-mode fiber employing a trench index profile for indoor wiring is proposed to realize low-bending loss and low-splice loss simultaneously. The designs and the advantages of the fiber over fibers with conventional step index profiles are described. The characteristics of manufactured fibers with trench index profiles are also described. One of the manufactured fibers realizes a bending loss of 0.018 dB/turn at 1550 nm for a bending radius of 7.5 mm, and a splice loss of 0.19 dB at 1550 nm in mechanical splicing to a conventional single mode fiber simultaneously. Other one of the fibers realizes a bending loss of 0.01 dB/tum at 1550 nm for a bending radius of 5 mm, and the splice loss is 0.37 dB at 1550 nm simultaneously. A total loss of a fiber employing the trench index is small and stable against the fluctuation of MFD.