gebhart/patrepeval huggingface dataset:
Bone-Directed Expression of Col1a1 Promoter-Driven Self-Inactivating Retroviral Vector in Bone Marrow Cells and Transgenic Mice (2001)

Gene therapy of bone would benefit from the availability of vectors that provide stable, osteoblast-specific expression. This would allow bone-specific expression of Col1a1 cDNAs for treatment of osteogenesis imperfecta. In addition, such a vector would restrict expression of secreted therapeutic proteins to the bone-synthesizing regions of the bone marrow after ex vivo transduction of marrow stromal cells and reintroduction of the cells into patients. Retrovirus vectors stably integrate into target cell genomes; however, long-term regulated expression from internal cellular promoters has not been consistently achieved. In some cases this is due to a stem cell-specific mechanism for transcriptional repression of retroviruses. We evaluated the ability of self-inactivating ROSA-derived vectors containing a bone-directed 2.3-kb rat Col1a1 promoter to display osteoblast-specific expression. In vitro expression was examined in bone marrow stromal cell cultures induced to undergo osteoblastic differentiation. In vivo expression was evaluated in chimeric mice derived from transduced embryonic stem cells. The results indicate that self-inactivating retrovirus vectors containing the Col1a1 promoter are not permanently inactivated in embryonic stem cells and are specifically expressed in osteoblasts in vivo and in vitro. Thus these vectors should be useful for bone-directed gene therapy.
Mechanical, permeability, and degradation properties of 3D designed poly(1,8 octanediol‐<i>co</i>‐citrate) scaffolds for soft tissue engineering (2010)

Poly(1,8-octanediol-co-citric acid) (POC) is a synthetic biodegradable elastomer that can be processed into three-dimensional (3D) scaffolds for tissue engineering. We investigated the effect of designed porosity on the mechanical properties, permeability, and degradation profiles of the POC scaffolds. For mechanical properties, scaffold compressive data were fitted to a one-dimensional (1D) nonlinear elastic model, and solid tensile data were fitted to a Neohookean incompressible nonlinear elastic model. Chondrocytes were seeded on scaffolds to assess the biocompatibility of POC. Increased porosity was associated with increased degradation rate, increased permeability, and decreased mechanical stiffness, which also became less nonlinear. Scaffold characterization in this article will provide design guidance for POC scaffolds to meet the mechanical and biological parameters needed for engineering soft tissues such as cartilage.
ChemInform Abstract: THE SYNTHESIS OF SOME SUBSTITUTED TETRAARYLPORPHYRINS (1975)

Abstract Nach bekannten Verfahren wird eine Vielzahl von symmetrischen und unsymmetrischen Tetraarylporphyrinen (I) hergestellt.
Substitutional Reality System: A Novel Experimental Platform for Experiencing Alternative Reality (2012)

We have developed a novel experimental platform, referred to as a substitutional reality (SR) system, for studying the conviction of the perception of live reality and related metacognitive functions. The SR system was designed to manipulate people's reality by allowing them to experience live scenes (in which they were physically present) and recorded scenes (which were recorded and edited in advance) in an alternating manner without noticing a reality gap. All of the naïve participants (n = 21) successfully believed that they had experienced live scenes when recorded scenes had been presented. Additional psychophysical experiments suggest the depth of visual objects does not affect the perceptual discriminability between scenes, and the scene switch during head movement enhance substitutional performance. The SR system, with its reality manipulation, is a novel and affordable method for studying metacognitive functions and psychiatric disorders.
Ultrafast Three-Dimensional Surface Imaging Based on Short-Time Fourier Transform (2015)

A novel approach to achieving ultrafast three-dimensional (3-D) imaging based on space-to-wavelength-to-time mapping and short-time Fourier transform (STFT) is proposed and experimentally demonstrated. The fundamental concept to achieve 3-D imaging is to encode the depth information of a sample by interfering two delayed pulses that are reflected from the surface of the sample and an additional reference plane on the top of the sample. The interference pattern that contains the depth information in the frequency domain is converted into the time domain based on dispersive Fourier transform and then analyzed based on STFT. Thus, ultrafast 3-D imaging is achieved. The proposed approach is experimentally evaluated. The imaging of a sample with a depth of 1.5 mm using an ultrafast pulse laser source with a beam width of ~2 mm at a repetition rate of 48.8 MHz is demonstrated.
Steroid potentiation of beta-adrenergic-sensitive adenylate cyclase in rabbit ciliary processes. (1987)

Dexamethasone (3.3 X 10(-8) M) potentiated 1-isoproterenol-stimulated adenylated cyclase activity in vitro in rabbit ciliary process epithelial membrane preparations. The ka for isoproterenol stimulation of the cyclase was 5 X 10(-7) M in control membranes, 2.5 X 10(-9) M in membranes preincubated with dexamethasone, and 6 X 10(-8) M with corticosterone. No change was observed in basal adenylate cyclase activity. Changes in enzyme activity at maximally stimulating levels of isoproterenol were not consistently different. Dose response to corticosterone in the presence of 10(-7) M 1-isoproterenol shows maximum effect at 6.6 X 10(-8) M corticosterone.
Chronocoulometric determination of nitrate on silver electrode and sodium hydroxide electrolyte (2007)

An electrochemical system that consists of a silver electrode in 0.01 M sodium hydroxide electrolyte was investigated in an effort to develop a sensitive in situ analytical method for nitrate. Cyclic voltammetry demonstrated that the proposed system has a high normalized sensitivity (2.47 A s(1/2) V(-1/2) M(-1) cm(-2)), compared to more complex electroanalytical schemes. Double-potential-step chronocoulometry was used to maximize the signal-to-noise ratio (SNR), and minimize interference from dissolved oxygen in the electrolyte. The integration period for double-potential-step chronocoulometry was determined by optimizing the extended Cottrell equation. The integrated current is proportional to nitrate up to 10 mM and the average detection limit is approximately 1.7 microM. Dissolved oxygen does not degrade performance. To examine the potential interference of other ions when analyzing nitrate, we measured the electrode response to 1000 microM each of NO(2-), Cl(-), PO(4)(3-), SO(4)(2-), F(-), CO(3)(2-), BO(2-), K(+), Ca(2+), and Sr(2+) with and without 1000 microM nitrate. Interference is negligible for most of the ions when nitrate is absent (i.e. <1% of the response to equimolar nitrate). However, interference is substantial (>20% increase or decrease in the electrode response to nitrate) for PO(4)(3-), Ca(2+), and Sr(2+) when equimolar nitrate is present.
Sucrose diacrylate: A unique chemically and biologically degradable crosslinker for polymeric hydrogels (1997)

A series of degradable hydrogels based on different vinyl monomers such as acrylamide, sucrose-1′-acrylate, and acrylic acid were synthesized using sucrose-6,1′-diacrylate (SDA) as a crosslinking agent. SDA was prepared by enzymatic transesterification of vinyl acrylate with sucrose in pyridine. Base catalyzed hydrolysis of SDA in aqueous solution was studied as a function of pH. As expected, hydrolysis of SDA was faster at higher pHs such that poly(acrylamide), poly(sucrose 1′-acrylate), and poly(acrylic acid) hydrogels underwent substantial degradation at and above pH 7, 9, and 13, respectively. The degradation was characterized by changes in the swelling ratios of the hydrogels indicating breakage of the crosslinking agent. Degradation of the hydrogels at their chemically stable pHs was studied in presence of enzymes. Enzymes, including pepsin and a fungal Lipase, were able to degrade the poly(acrylamide) hydrogel at pH 4 and 5, respectively. Poly(acrylic acid) hydrogel was degraded in presence of a fungal protease at pH 7.8. © 1997 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 35: 2221–2229, 1997
IgG Antibodies in Food Allergy Influence Allergen–Antibody Complex Formation and Binding to B Cells: A Role for Complement Receptors (2013)

Allergen-IgE complexes are more efficiently internalized and presented by B cells than allergens alone. It has been suggested that IgG Abs induced by immunotherapy inhibit these processes. Food-allergic patients have high allergen-specific IgG levels. However, the role of these Abs in complex formation and binding to B cells is unknown. To investigate this, we incubated sera of peanut- or cow's milk-allergic patients with their major allergens to form complexes and added them to EBV-transformed or peripheral blood B cells (PBBCs). Samples of birch pollen-allergic patients were used as control. Complex binding to B cells in presence or absence of blocking Abs to CD23, CD32, complement receptor 1 (CR1, CD35), and/or CR2 (CD21) was determined by flow cytometry. Furthermore, intact and IgG-depleted sera were compared. These experiments showed that allergen-Ab complexes formed in birch pollen, as well as food allergy, contained IgE, IgG1, and IgG4 Abs and bound to B cells. Binding of these complexes to EBV-transformed B cells was completely mediated by CD23, whereas binding to PBBCs was dependent on both CD23 and CR2. This reflected differential receptor expression. Upon IgG depletion, allergen-Ab complexes bound to PBBCs exclusively via CD23. These data indicated that IgG Abs are involved in complex formation. The presence of IgG in allergen-IgE complexes results in binding to B cells via CR2 in addition to CD23. The binding to both CR2 and CD23 may affect Ag processing and presentation, and (may) thereby influence the allergic response.
Bump heat sink technology - A novel assembly technology suitable for power HBTs (2002)

A novel assembly technique, bump heat sink (BHS), suitable for compound semiconductor power HBTs is proposed and demonstrated. In this technique, the heat generated in the transistor junction is effectively conducted away through a gold bump which is located on the top of each transistor unit. Using this technique, power transistors are demonstrated with power added efficiencies /spl eta//sub add/ of 74%, 66% and 61% for 5.0 W, 8.0 W and 10.0 W output CW, respectively, at 0.9 GHz with V/sub cc/=6 V. A three-stage HBT MMIC power amplifier for GSM class 4 is also demonstrated with /spl eta//sub add/ >55% at V/sub cc/=4 V CW operation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Age-related performance on the wisconsin card sorting, similarities, and controlled oral word association tests (1992)

Abstract Clinical psychologists and neuropsychologists are frequently called upon to assist other health professionals in distinguishing normal age-related cognitive changes from abnormal neurocognitive changes likely to be associated with pathological processes of the aging brain. Such distinctions are made more difficult in the absence of normative data from clinical tests considered sensitive to normal age-related changes. Three tests of conceptualization skills, the Wisconsin Card Sorting Test (WCST), Similarities from the WAIS-R (WAIS-R-SML), and the Controlled Oral Word Association Test (COWAT), were given to 80 healthy independently living individuals, ages 50 through 89 years, grouped into four age decades. Results revealed a progressive age-related decline in performance on these tasks. Changes in these executive functioning skills were found to be unrelated to intellectual competence, educational experience, or the general health status of the participants.
Airway Surface Dehydration in Cystic Fibrosis: Pathogenesis and Therapy (2007)

Cystic fibrosis (CF) lung disease reflects the failure of airways defense against chronic bacterial infection. Studies of CF cultures, transgenic mice, and CF patients suggest that the initiating event in CF airways disease pathogenesis is reduced airway surface liquid (ASL) volume, i.e., dehydration. CF ASL volume regulation depends on a single extracellular signaling system, ATP, which renders CF airways more vulnerable to disease-causing insults (e.g., viruses) than are normal airways, which regulate ASL volume by dual ATP and adenosine signaling pathways. Clinical studies have explored the hypothesis that treating the dehydration of CF airways will be therapeutically beneficial. Inhaled hypertonic saline osmotically draws water onto airway surfaces, improves mucus clearance and pulmonary function, and reduces acute exacerbations in CF patients. Thus, rehydration therapies may slow the progression of CF lung disease in patients with established bacterial infection and may prevent the onset of CF lung disease if initiated early in life.
Chemical Quality Evaluation of Damaged Jojoba Seeds (<i>Simmondsia chinensis</i>) (2008)

Abstract The objective of the research was to characterize the quality of damaged and undamaged jojoba seeds. The study was performed on jojoba seeds grown in La Rioja, Argentina. Proximal composition, fatty acid composition, acid value, peroxide value, conjugated dienes and trienes and protein electrophoresis profiles were determined in undamaged (JS) and damaged jojoba seeds (DJS). The fat content (wax) was lower in DJS (39.11%) than in JS (50.82%). The values of acid, peroxide, conjugated dienes and trienes were higher in DJS than in JS. No difference in fatty acid composition was observed between DJS and JS. The protein content was not significantly different between JS and DJS. However, DJS had lower soluble protein values. In the electrophoresis profiles, the band located at 50 kDa disappeared in DJS and the intensity of the band located at 25 kDa decreased. The deterioration process in jojoba kernels significantly affects the chemical quality of their proteins and waxes.
465. The action of sodium ethoxide on chroman-4-ones (1950)

E. M. Padfield and M. L. Tomlinson, J. Chem. Soc., 1950, 2272 DOI: 10.1039/JR9500002272
Recognition of blacklisted vehicle based on SIFT feature (2016)

With the rapid development of technology, the intelligent traffic system is an important tool for traffic police in combating crime involving vehicles. In recent years, the recognition of blacklisted vehicle models is becoming more and more essential for crime tracking. However, it can be proved that the classical method of recognition, SIFT, has low accuracy when there are plenty of feature points with noise. In addition, current work in this field only focus on a few fuzzy classifications with not much practical value and testing in only one assessment method that doesn't have comprehensive representativeness. This paper proposes a novel method by using template library based on SIFT feature in order to solve these problems. The method pick up some commonly used vehicle models and test performance of algorithm based on Confusion matrix. Confirmed by the experiments, the proposed method has higher accuracy and only has a tiny delay.
Material design of nanocellulose/polymer composites via Pickering emulsion templating (2020)

Abstract Cellulose nanofiber (CNF) is a crystalline fiber composed of a bundle of cellulose molecular chains and is expected to be used as a new biomass-derived nanomaterial. The CNF has a unique morphology: a few to tens of nanometer width and a submicrometer to micrometer length. Its application to various materials, in particular its utilization as a polymer reinforcing material, has been anticipated due to its excellent mechanical properties. However, CNFs and plastics are generally hard to mix, and thus, it is difficult to combine them at the nanolevel. In this review, we describe the CNF/polymer nanocompositing process from Pickering emulsion. We use ~3 nm-wide wood-derived CNFs and report on the preparation of CNF/polymer homogenous composite films. We also introduce a new type of CNF/polymer composite, a core-shell microparticle, using this Pickering emulsion as a template.
Personalizing carbamazepine therapy (2011)

The anticonvulsant carbamazepine has a high incidence of cutaneous adverse drug reactions. A recent prospective clinical trial in Taiwan has indicated that HLA-B*1502 screening will reduce the incidence of life-threatening adverse reactions to carbamazepine, while a genome-wide association study has identified the HLA-A*3101 allele as a genetic risk factor for the full spectrum of carbamazepine-induced cutaneous adverse drug reactions in a European population. These studies should aid future decision-making for personalized use of carbamazepine treatment.
Murdoch on Good and Evil (2019)

Iris Murdoch is the most outstanding British moral philosopher in the 20th century. Her philosophical researches concentrate on the moral awareness of British people in the sea of turmoil caused by the confrontations between material world and spiritual realm. She holds that in the modern world where God is absent, people should take the highest goodness as their moral belief. She endeavors to provide people in the West with Oriental Buddhism to achieve spiritual salvation. As a sentient being, one can surpass the boundaries and get rid of those things obsessing him, and in this manner, he can have a clear idea about the real world in which other people live and strike a balance between himself and otherness.
Is Topical Anesthesia Useful in Noninvasive Skin Tightening Using Radiofrequency? (2006)

The use of anesthesia did not affect the final efficacy of the treatment compared with no anesthesia.
Rapid and accurate inter-robot position determination in robot teams (2001)

We describe a rapid and accurate method to measure robot-to-robot separations and headings. The method, which uses narrow bandwidth signals that are well suited for ultrasonic transducers and for dispersive acoustic environments, detects the difference in phase delay of an optical and an ultrasonic signal. A prototype system based on microcontrollers for signal generation and phase delay measurement determined the location of another robot with sub-centimeter accuracy over a 2.5 m range with a 53 ms measurement time. We also describe simple modifications that can be made to increase the range without loss of accuracy and to coordinate measurements among many robots.
Ethyl 2-acetamido-4,6-di-O-benzyl-2,3-N,O-carbonyl-2-deoxy-1-thio-β-d-glycopyranoside as a versatile GlcNAc donor (2005)

The title donor, ethyl 2-acetamido-4,6-di-O-benzyl-2,3-N,O-carbonyl-2-deoxy-1-thio-beta-D-glycopyranoside, is shown to be an excellent glycosyl donor giving immediate and efficient access to variant GlcNAc-containing oligosaccharides.
Synthetic Rubber (1933)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthetic RubberG. S. Whitby and M. KatzCite this: Ind. Eng. Chem. 1933, 25, 12, 1338–1348Publication Date (Print):December 1, 1933Publication History Published online1 May 2002Published inissue 1 December 1933https://pubs.acs.org/doi/10.1021/ie50288a012https://doi.org/10.1021/ie50288a012research-articleACS PublicationsRequest reuse permissionsArticle Views288Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Integrated class DE synchronized DC-DC converter for on-chip power supplies (2006)

A 12.5-mW dc-dc resonant converter with a 500 MHz class DE power inverter and class E synchronous rectifier was designed and simulated on a 1.2 μm CMOS process chip. A 20 nH spiral inductor was used in the resonant circuit. The class DE inverter requires lower inductance than the PWM buck converter. Soft switching operation enables high conversion efficiency at high operating frequencies. The class DE inverter is a good candidate for on-chip switching converters because of very high efficiency, smaller passive elements, and low peak switch voltage.
3D seismic monitoring for enhancing thermal recovery (1996)

Previous No AccessSEG Technical Program Expanded Abstracts 19963D seismic monitoring for enhancing thermal recoveryAuthors: John EastwoodDon AndersonTom BooneJohn EastwoodImperial Oil Limited, Oil Sands Research and Technology, Calgary, Alberta, Don AndersonImperial Oil Limited, Oil Sands Research and Technology, Calgary, Alberta, and Tom BooneImperial Oil Limited, Oil Sands Research and Technology, Calgary, Albertahttps://doi.org/10.1190/1.1826598 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1826598FiguresReferencesRelatedDetailsCited ByA case history of experimental time-lapse 3C 2D seismic reflection data for reservoir monitoring at Cold Lake, Alberta, CanadaJ. Helen Isaac and Don C. Lawton23 April 2014 | Interpretation, Vol. 2, No. 2Interpretation of 4D Seismic Data: Case History Reading List29 August 2013Cross‐equalization data processing for time‐lapse seismic reservoir monitoring: A case study from the Gulf of MexicoJ. E. Rickett and D. E. Lumley7 February 2012 | GEOPHYSICS, Vol. 66, No. 4 SEG Technical Program Expanded Abstracts 1996ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1996 Pages: 2106 publication data© 1996 Copyright © 1996 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 10 Feb 2005 CITATION INFORMATION John Eastwood, Don Anderson, and Tom Boone, (1996), "3D seismic monitoring for enhancing thermal recovery," SEG Technical Program Expanded Abstracts : 2103-2106. https://doi.org/10.1190/1.1826598 Plain-Language Summary PDF DownloadLoading ...
A Graphical Case Statistic for Assessing Posterior Influence (1992)

m A Graphical Case Statistic for Assessing Posterior Influence STOR Robert E . Weiss; R. Dennis Cook Biometrika, Volume 79, Issue 1 (Mar., 1992), 51-55. Stable U R L : http://links.jstor.org/sici?sici=0006-3444%28199203%2979%3Al%3C51%3AAGCSFA%3E2.0.CO%3B2-R Your use of the JSTOR archive indicates your acceptance of JSTOR's Terms and Conditions of Use, available at http://www.jstor.org/about/terms.html. JSTOR's Terms and Conditions of Use provides, in part, that unless you have obtained prior permission, you may not download an entire issue of a journal or multiple copies of articles, and you may use content in the JSTOR archive only for your personal, non-commercial use. Each copy of any part of a JSTOR transmission must contain the same copyright notice that appears on the screen or printed page of such transmission. Biometrika is published by Biometrika Trust. Please contact the publisher for further permissions regarding the use of this work. Publisher contact information may be obtained at http://www.jstor.org/journals/bio.html. Biometrika ©1992 Biometrika Trust JSTOR and the JSTOR logo are trademarks of JSTOR, and are Registered in the U.S. Patent and Trademark Office. For more information on JSTOR contactjstor-info@umich.edu. ©2003 JSTOR http://www.j stor.org/ Mon Feb 10 11:20:03 2003