gebhart/patrepeval huggingface dataset:
BLACR: TTP -free blacklistable anonymous credentials with reputation (2012)

Anonymous authentication can give users the license to misbehave since there is no fear of retribution. As a deterrent, or means to revocation, various schemes for accountable anonymity feature some kind of (possibly distributed) trusted third party (TTP) with the power to identify or link misbehaving users. Recently, schemes such as BLAC and PEREA showed how anonymous revocation can be achieved without such TTPs—anonymous users can be revoked if they misbehave, and yet nobody can identify or link such users cryptographically. Despite being the state of the art in anonymous revocation, these schemes allow only a basic form of revocation amounting to ‘revoke anybody with d or more misbehaviors’ or ‘revoke anybody whose combined misbehavior score is too high’ (where misbehaviors are assigned a ‘severity’ score). We present BLACR, which significantly advances anonymous revocation in three ways: 1) It constitutes a first attempt to generalize reputation-based anonymous revocation, where negative or positive scores can be assigned to anonymous sessions across multiple categories. Servers can block users based on policies, which specify a boolean combination of reputations in these categories; 2) We present a weighted extension, which allows the total severity score to ramp up for multiple misbehaviors by the same user; and, 3) We make a significant improvement in authentication times through a technique we call express lane authentication, which makes reputation-based anonymous revocation practical.
Crowd-sourced Semantic Edge Mapping for Autonomous Vehicles (2019)

Highly accurate maps of the road infrastructure are a crucial cornerstone for self-driving cars to enable navigation in complex traffic scenarios. Traditional methods for creating detailed maps of road environments involve expensive survey vehicles that cannot keep up with the frequent changes in the road network. In this paper, we propose a novel method to derive detailed high-definition maps by crowd sourcing data using commodity sensors. Our system uses multi-session feature-based visual SLAM to align submaps recorded by individual vehicles on a central backend server. We reconstruct 3D boundaries of road infrastructure elements such as road markings and road boundaries from semantic object contours detected in keyframes by a neural network. The result is a concise map of semantically meaningful objects suitable both for localization and higher-level planning tasks of automated vehicles. We evaluate our method on real-world data against a globally referenced ground-truth map demonstrating a high level of detail and metric accuracy.
Efficacy and Safety of Single-Agent Pertuzumab, a Human Epidermal Receptor Dimerization Inhibitor, in Patients with Non–Small Cell Lung Cancer (2007)

Pertuzumab is well tolerated as monotherapy. Pharmacodynamic activity correlated with prolonged PFS was detected in a moderate percentage of patients (27.3%). Further clinical development of pertuzumab should focus on rational combinations of pertuzumab with other drugs active in NSCLC.
COOH-terminal Substitutions in the Serpin C1 Inhibitor That Cause Loop Overinsertion and Subsequent Multimerization (1995)

The region COOH-terminal to the reactive center loop is highly conserved in the serine protease inhibitor (serpin) family. We have studied the structural consequences of three substitutions (Val451-->Met, Phe455-->Ser, and Pro476-->Ser) found in this region of C1 inhibitor in patients suffering from hereditary angioedema. Equivalent substitutions have been described in alpha 1-antitrypsin and antithrombin III. The mutant C1 inhibitor proteins were only partially secreted upon transient transfection into COS-7 cells and were found to be dysfunctional. Immunoprecipitation of conditioned media demonstrated that in the intact, uncleaved form they all bind to a monoclonal antibody which recognizes specifically the protease-complexed or reactive center-cleaved normal C1 inhibitor. A second indication for an intrinsic conformational change was the increased thermostability compared to the normal protein. Furthermore, gel filtration studies showed that the Val451-->Met and Pro476-->Ser mutant proteins, and to a lesser extent Phe455-->Ser, were prone to spontaneous multimerization. Finally, a reduced susceptibility to reactive center cleavage by trypsin was observed for all three mutants, and the cleaved Val451-->Met and Pro476-->Ser mutants failed to adopt the conformation recognized by a cleavage-specific monoclonal antibody. Investigation of plasmas of patients with the Val451-->Met or Pro476-->Ser substitutions showed that these dysfunctional proteins circulate at low levels and are recognized by the complex-specific antibody. These results strongly indicate a conformational change as a result of these carboxylterminal substitutions, such that anchoring of the reactive center loop at the COOH-terminal side is not achieved properly. We propose that this results in overinsertion of the loop into beta-sheet A, which subsequently leads to multimerization.
Purification and Characterization of the Commercialized, Cloned <i>Bacillus megaterium</i> α‐Amylase. Part I: Purification and Hydrolytic Properties (1991)

Abstract An amylolytic enzyme, originally isolated from Bacillus megaterium. was shown to increase the maximum amount of dextrose produced during saccharification by decreasing the amount of residual oligosaccharides. The enzyme, now commercially produced in a genetically engineered strain of Bacillus subtilis , was purified to homogeneity from the commercial product. A combination of gel permeation chromatography in the presence of 1.0 M NaCl and chromatofocusing between pH 9.0 and 7.0 were used to obtain the pure enzyme. The molecular weight of the Bacillus megaterium α‐amylase was 59,000 by SDS gel electrophoresis, and the isoelectric point was 8.9 to 9.0. The enzyme was shown to possess both hydrolytic and transferase activity. The enzyme hydrolyzed a wide variety of soluble substrates. The rate of hydrolysis was greatest on soluble starch; α(1,6)‐branched substrates and cyclodextrins were hydrolyzed more slowly.
Workflow-supported organizational memory systems: an industrial application (2003)

Workflow management technology has evolved from efficiency-oriented process automation tools to knowledge network building and support systems. This paper presents a workflow management application that collects information-rich business process documents, stores them in an organizational memory system, and informates staff and management in various situations. Combining ASAP R/3 as the workflow machine and IXOAS-ARCHIVE as the knowledge repository of the organizational memory system enabled us to explore powerful options in organizational knowledge distribution. We have been able to document and report organizational performance gains in terms of both process efficiency and knowledge effectiveness.
Free molecular transport and deposition in long rectangular trenches (1990)

Integral equations are derived which describe free molecular flow and simultaneous film deposition in long rectangular trenches. The equations apply to flow in the absence of deposition and to both low-pressure chemical vapor deposition (LPCVD) and physical vapor deposition (PVD), i.e., over the full range of reactant sticking coefficient from zero to unity. A steady-state assumption is implicit in the formulation. In the absence of film deposition, the flux to the surface is spatially uniform. Analytical expressions are presented for the initial deposition profiles along the trench sides and bottom for PVD (unity sticking coefficient). Numerical inversion of the integral equations provides initial deposition profiles for LPCVD (low sticking coefficient). The calculated initial deposition profiles are consistent with empirical results which typically show poor uniformity in PVD and high uniformity in LPCVD, and also compare well with Monte Carlo based simulations of deposition processes.
Spatial filtering in tone reproduction and vision (1992)

This thesis is concerned with spatial filtering. What is its utility in tone reproduction? Does it exist in vision, and if so, what constraints does it impose on the nervous system? Tone reproduction is just the art and science of taking a picture and then displaying it. The sensors available to capture an image have a greater dynamic range than the media that may be used to display it. Conventionally, spatial filtering is used to boost contrast; it ameliorates the loss of contrast that results when the sensor signal range is scaled down to fit the display range. In this thesis, a type of nonlinear spatial filtering is discussed that results in direct range reduction without range scaling. This filtering process is instantiated in a real-time image processor built using analog CMOS VLSI. Spatial filtering must be applied with care in both artificial and natural vision systems. It is argued that the nervous system does not simply filter linearly across an image. Rather, the way that we see things implies that the nervous system filters nonlinearly. Further, many models for color vision include a high-pass filtering step in which the DC information is lost. A real-time study of filtering in color space leads to the conclusion that the nervous system is not that simple, and that it maintains DC information by referencing to white.
A Feasibility Study of the Intraductal Administration of Chemotherapy (2012)

Preclinical data have shown the potential of the intraductal administration of chemotherapy for breast cancer prevention. Direct translation of this work has been stymied by the anatomical differences between rodents (one duct per teat) and women (5-9 ductal systems per breast). The objective of this phase I study was to show the safety and feasibility of intraductal administration of chemotherapy drugs into multiple ducts within one breast in women awaiting mastectomy for treatment of invasive cancer. Thirty subjects were enrolled in this dose escalation study conducted at a single center in Beijing, China. Under local anesthetic, one of two chemotherapy drugs, carboplatin or pegylated liposomal doxorubicin (PLD), was administered into five to eight ducts at three dose levels. Pharmacokinetic analysis has shown that carboplatin was rapidly absorbed into the bloodstream, whereas PLD, though more erratic, was absorbed after a delay. Pathologic analysis showed marked effects on breast duct epithelium in ducts treated with either drug compared with untreated ducts. The study investigators had no difficulty in identifying or cannulating ducts except in one case with a central cancer with subareolar involvement. This study shows the safety and feasibility of intraductal administration of chemotherapy into multiple ducts for the purpose of breast cancer prevention. This is an important step toward implementation of this strategy as a "chemical mastectomy", where the potential for carcinogenesis in the ductal epithelium is eliminated pharmacologically, locally, and without the need for surgery.
Ten Years of Digital Visual Restoration Systems (2007)

With the growth in marketability of all forms of visual media comes the need to exploit archive material more effectively, and a requirement to guarantee picture quality regardless of the originating medium. Some kind of touch-up or restoration is rapidly becoming a "must have" in the visual production cycle. This paper reviews the development and impact of digital restoration systems in the broadcast television and film industry over the last ten years. It presents some unifying ideas as well as the relevance and challenges of defect treatment in such harsh picture environments.
Continuous Administration of Basic Fibroblast Growth Factor (FGF-2) Accelerates Bone Induction on Rat Calvaria— An Application of a New Drug Delivery System (1998)

Some studies have shown that locally applied basic fibroblast growth factor (FGF-2) enhances bone regeneration at a fracture site, while others have not been in agreement. We developed a new continuous FGF-2 delivery system designed to accelerate cytokine-induced new bone formation. A subperiosteal pocket was surgically formed in 36 eight-week-old male Wistar rats. The rats were administered 0, 1, 10, or 100 ng of FGF-2 contained in a collagen minipellet, mixed with allogeneic demineralized bone matrix in a dome-shaped Millipore filter and then placed into the pocket. New bone formation in the dome was evaluated at 2, 4, and 8 wks after placement. Soft x-ray radiographs disclosed an apparently larger radiopaque region in the 1-ng group at 4 wks compared with those in the other groups. Morphometrical analysis revealed that the new bone area in the 1-g group was significantly larger than that in the 0-g group (p<0.01). In the 100-ng FGF-2 group, new bone formation seemed suppressed. We concluded that continuous slow administration of a small amount of FGF-2 accelerates bone-derived osteogenic cytokine-induced new bone formation.
On the Poly(beta-DL-aspartic acid) (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOn the Poly(beta-DL-aspartic acid)Masayo Matsuyama, Etsuo Kokufuta, Takenori Kusumi, and Kaoru HaradaCite this: Macromolecules 1980, 13, 1, 196–198Publication Date (Print):January 1, 1980Publication History Published online1 May 2002Published inissue 1 January 1980https://doi.org/10.1021/ma60073a040RIGHTS & PERMISSIONSArticle Views130Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (396 KB) Get e-Alerts Get e-Alerts
Medical Concept Representation Learning from Claims Data and Application to Health Plan Payment Risk Adjustment (2019)

Risk adjustment has become an increasingly important tool in healthcare. It has been extensively applied to payment adjustment for health plans to reflect the expected cost of providing coverage for members. Risk adjustment models are typically estimated using linear regression, which does not fully exploit the information in claims data. Moreover, the development of such linear regression models requires substantial domain expert knowledge and computational effort for data preprocessing. In this paper, we propose a novel approach for risk adjustment that uses semantic embeddings to represent patient medical histories. Embeddings efficiently represent medical concepts learned from diagnostic, procedure, and prescription codes in patients' medical histories. This approach substantially reduces the need for feature engineering. Our results show that models using embeddings had better performance than a commercial risk adjustment model on the task of prospective risk score prediction.
Emerging novel treatments for autoimmune liver diseases (2019)

The etiology of autoimmune liver diseases, such as autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC), still remains largely unknown and no therapeutic agents that are able to "cure" these diseases have been developed. Although corticosteroids for AIH and ursodeoxycholic acid for PBC have been shown to significantly improve liver transplantation (LT)-free survival and are recommended as first-line drugs, treatment strategies for patients who show incomplete response to these drugs have not yet been fully established. No drug is significantly associated with long LT-free survival in PSC patients. Nevertheless, with progress in genetics, immunology, and cellular biology, several new compounds or antibodies are expected to have an effect on autoimmune liver diseases and several drugs are under consideration for clinical use. Although most clinical trials have been carried out in the USA or Europe, some are, or will be, undertaken in Japan in the future. In this review, the current standard-of-care of autoimmune liver diseases will be summarized, together with emerging novel treatments relevant to clinical practice in Japan.
Quantitative assessment of motor fatigue and strength in MS (1999)

Strength and motor fatigue can be measured reliably in patients with MS. MS patients experience more fatigue than healthy control subjects during sustained contractions, repetitive contractions, and ambulation. Motor fatigue appears to be distinct from weakness because the degree of fatigue was not associated with the degree of weakness in individual muscles. Quantitative assessment of strength and fatigue may be useful to monitor changes in motor function over time in MS patients.
Effects of acute and chronic hyperglycemia on the neurochemical profiles in the rat brain with streptozotocin‐induced diabetes detected using <i>in vivo</i><sup>1</sup>H MR spectroscopy at 9.4 T (2012)

Chronic hyperglycemia could lead to cerebral metabolic alterations and CNS injury. However, findings of metabolic alterations in poorly managed diabetes in humans and animal models are rather inconsistent. We have characterized the cerebral metabolic consequences of untreated hyperglycemia from the onset to the chronic stage in a streptozotocin-induced rat model of diabetes. In vivo ¹H magnetic resonance spectroscopy was used to measure over 20 neurochemicals longitudinally. Upon the onset of hyperglycemia (acute state), increases in brain glucose levels were accompanied by increases in osmolytes and ketone bodies, all of which remained consistently high through the chronic state of over 10 weeks of hyperglycemia. Only after over 4 weeks of hyperglycemia, the levels of other neurochemicals including N-acetylaspartate and glutathione were significantly reduced and these alterations persisted into the chronic stage. However, glucose transport was not altered in chronic hyperglycemia of over 10 weeks. When glucose levels were acutely restored to euglycemia, some neurochemical changes were irreversible, indicating the impact of prolonged uncontrolled hyperglycemia on the CNS. Furthermore, progressive changes in neurochemical levels from control to acute and chronic conditions demonstrated the utility of ¹H magnetic resonance spectroscopy as a non-invasive tool in monitoring the disease progression in diabetes.
ToD Pilot: A Location-based Taxi on Demand System Demonstrator (2007)

In this paper we present the results of the Taxi on Demand (ToD) system Test Trial which was conducted on 25-29 June, 2007. The ToD system, featuring a location-based and traffic-sensitive methodology, incorporates automated taxi booking, dispatching and monitoring functionalities. The ToD solution effectively addresses current taxi sector needs, and may be expanded to emerging car-pooling/sharing models, allowing integration between modes of transport in urban or densely populated environments.
Smart Memories: a modular reconfigurable architecture (2002)

Trends in VLSI technology scaling demand that future computing devices be narrowly focused to achieve high performance and high efficiency, yet also target the high volumes and low costs of widely applicable general purpose designs. To address these conflicting requirements, we propose a modular reconfigurable architecture called Smart Memories, targeted at computing needs in the 0.1 /spl mu/m technology generation. A Smart Memories chip is made up of many processing tiles, each containing local memory, local interconnect, and a processor core. For efficient computation under a wide class of possible applications, the memories, the wires, and the computational model can all be altered to match the applications. To show the applicability of this design, two very different machines at opposite ends of the architectural spectrum, the Imagine stream processor and the Hydra speculative multiprocessor, are mapped onto the Smart Memories computing substrate. Simulations of the mappings show that the Smart Memories architecture can successfully map these architectures with only modest performance degradation.
Using Readers' Highlighting on Monochromatic Documents for Automatic Text Transcription and Summarization (2011)

Very often interested readers highlight documents with felt pens. Such marking may be seen as personal view of the most important aspects of the document, which are used to instantly draw the readers' attention at. This article addresses ways of using the highlighting made by the reader of a book or a paper documents to automatically generate its text summary.
Effect of blood sampling schedule and method of calculating the area under the curve on validity and precision of glycaemic index values (2004)

To evaluate the suitability for glycaemic index (GI) calculations of using blood sampling schedules and methods of calculating area under the curve (AUC) different from those recommended, the GI values of five foods were determined by recommended methods (capillary blood glucose measured seven times over 2.0 h) in forty-seven normal subjects and different calculations performed on the same data set. The AUC was calculated in four ways: incremental AUC (iAUC; recommended method), iAUC above the minimum blood glucose value (AUCmin), net AUC (netAUC) and iAUC including area only before the glycaemic response curve cuts the baseline (AUCcut). In addition, iAUC was calculated using four different sets of less than seven blood samples. GI values were derived using each AUC calculation. The mean GI values of the foods varied significantly according to the method of calculating GI. The standard deviation of GI values calculating using iAUC (20.4), was lower than six of the seven other methods, and significantly less (P<0.05) than that using netAUC (24.0). To be a valid index of food glycaemic response independent of subject characteristics, GI values in subjects should not be related to their AUC after oral glucose. However, calculating GI using AUCmin or less than seven blood samples resulted in significant (P<0.05) relationships between GI and mean AUC. It is concluded that, in subjects without diabetes, the recommended blood sampling schedule and method of AUC calculation yields more valid and/or more precise GI values than the seven other methods tested here. The only method whose results agreed reasonably well with the recommended method (ie. within +/-5 %) was AUCcut.