gebhart/patrepeval huggingface dataset:
Container-managed messaging: an architecture for integrating Java components and message-oriented applications (2002)

Container-managed messaging (CMM) allows a Java component to communicate via messaging without having to manage the messaging infrastructure, similarly to how container-managed persistence (CMP) allows an EJB (Enterprise JavaBean) to have persistent data without managing access to a data store. In addition, messaging parameters (such as destinations, mode of interaction, time-outs, etc.) can be defined declaratively in a deployment descriptor. The programming model used in CMM resembles that of CORBA messaging with the exception that it is in an anonymous and declarative fashion.
A Simple Coding Procedure Enhances a Neuron's Information Capacity (1981)

The contrast-response function of a class of first order interneurons in the fly's compound eye approximates to the cumulative probability distribution of contrast levels in natural scenes. Elementary information theory shows that this matching enables the neurons to encode contrast fluctuations most efficiently.
Correction for preload in assessment of myocardial contractility in aortic and mitral valve disease. Application of the concept of systolic myocardial stiffness. (1988)

With single-beat analysis, the new concept of systolic myocardial stiffness is applied to provide a new approach for the assessment of myocardial contractility in aortic and mitral valve disease. Seventy patients underwent diagnostic right and left heart catheterization. Twenty-six patients had aortic stenosis, 18 had aortic insufficiency, and 26 had mitral regurgitation. Patients with aortic stenosis were divided into two groups on the basis of left ventricular mass index less than 172 g/m2 (AS1) and mass index greater than or equal to 172 g/m2 (AS2). The mitral regurgitation patients were divided into those in normal sinus rhythm (MR1) and those in atrial fibrillation (MR2). Nine patients without significant coronary or cardiovascular disease served as controls. Thirteen patients with aortic stenosis and eight with aortic insufficiency were evaluated (average, approximately 18 months) after successful aortic valve replacement. With simultaneous left ventricular pressure and cineangiographic methods, myocardial contractility was assessed by the conventional ejection fraction-afterload relation (uncorrected for preload) and by two new methods that permit the correction of the ejection fraction for preload. Assessments of the contractile state by these two new methods differed from those by the conventional method in 20-40% of the cases studied. Contractile state improved postoperatively in aortic stenosis and aortic insufficiency even in patients with preoperative depressed contractile states. In patients with mitral regurgitation, there was considerable heterogeneity of contractile function preoperatively. Severe left ventricular hypertrophy in aortic stenosis was not a marker for postoperative outcome since contractility was normal postoperatively in AS1 and AS2 in equal numbers. This study demonstrates that preload correction is important in a preoperative assessment of contractility in aortic and mitral valve disease but that it is less important postoperatively, presumably because of reductions in the preload.
WAVSTAN: Waveform based Variational Static Timing Analysis (2007)

We present a waveform based variational static timing analysis methodology. It is a timing paradigm that lies midway between convention static delay approximations and full dynamic (SPICE-level) analysis. The core idea is to break the modulation of waveforms processed by a circuit into two parts: (a) non-linear circuit elements e.g., transistors, diodes etc. and (b) linear elements: transmission line, RLC network etc. The non-linear and linear parts of the circuit are then solved using a combination of current-source modeling, model order reduction methodology, perturbation analysis and learning-based Galerkin methods which helps us get SPICE-like accuracies. The proposed method is potentially as robust and 10-20times faster than current-source based gate modeling methodologies
Sensory Stimulation for Lowering Intraocular Pressure, Improving Blood Flow to the Optic Nerve and Neuroprotection in Primary Open-Angle Glaucoma (2013)

Primary open-angle glaucoma is a group of optic neuropathies that can lead to irreversible blindness. Sensory stimulation in the form of acupuncture or ear acupressure may contribute to protecting patients from blindness when used as a complementary method to orthodox treatment in the form of drops, laser or surgery. The objective of this article is to provide a narrative overview of the available literature up to July 2012. It summarises reported evidence on the potential beneficial effects of sensory stimulation for glaucoma. Sensory stimulation appears to significantly enhance the pressure-lowering effect of orthodox treatments. Studies suggest that it may also improve blood flow to the eye and optic nerve head. Furthermore, it may play a role in neuroprotection through regulating nerve growth factor and brain-derived neurotrophic factor and their receptors, thereby encouraging the survival pathway in contrast to the pathway to apoptosis. Blood flow and neuroprotection are areas that are not directly influenced by orthodox treatment modalities. Numerous different treatment protocols were used to investigate the effect of sensory stimulation on intraocular pressure, blood flow or neuroprotection of the retina and optic nerve in the animal model and human pilot studies. Objective outcomes were reported to have been evaluated with Goldmann tonometry, Doppler ultrasound techniques and electrophysiology (pattern electroretinography, visually evoked potentials), and supported with histological studies in the animal model. Taken together, reported evidence from these studies strongly suggests that sensory stimulation is worthy of further research.
Solder column interposer for single chip ceramic packaging (2003)

Current desktop and consumer applications for microprocessors require that systems be Energy Star compliant. In addition, other power management initiatives such as Advanced Configuration and Power Interface (ACPI) define low power system states that the operating system controls. These initiatives are directed at reducing the energy consumption of desktop computer equipment during periods of inactivity as well as providing quick resumption of activity. From an electronic packaging perspective, systems will power down more often when not in use during typical conditions of daily use. Each power down cycle may result in a temperature excursion and affects the fatigue life of area array solder joints. This requirement results in the need of increased reliability of soldered surface mount ceramic packages. In this paper, we discuss a new type of ceramic package utilizing a solder column interposer to meet these reliability requirements.
The acquisition and accumulation of inorganic carbon by the unicellular green alga <i>Chlorella ellipsoidea</i> (1991)

Abstract. The uptake and accumulation of inorganic carbon has been investigated in Chlorella ellipsoidea cells grown at acid or alkaline pH. Carbonic anhydrase (CA) was detected in ceil extracts but not in intact cells and CA activity in acid‐grown cells was considerably less than that in alkali‐grown cells. Both cell types demonstrates low K 1/2 (CO 2 ) values in the range pH 7.0–8.0 and these were unaffected by O 2 concentration. The CO 2 compensation concentrations of acid‐ and alkali‐grown cells suspended in aqueous media were not significantly different in the range of pH 6.0–8.0, but at pH 5.0, the CO 2 compensation concentrations of acid‐grown cells (57.4cm 3 m −3 ) were lower than those of alkali‐grown cells (79.2cm 3 m −3 ). The rate of photo‐synthetic O 2 evolution in the range pH 7.5–8.0 exceeded the calculated rate of CO 2 supply two‐ to three‐fold, in both acid‐ and alkali‐grown cells, indicating that HCO 3 − was taken up by the cells. Accumulation of inorganic carbon was measured at pH 7.5 by silicone‐oil centri‐fugation, and the concentration of unfixed inorganic carbon was found to be 5.1 mol m −3 in acid‐grown and 6.4mol m −3 in alkali‐grown cells. These concentrations were 4.6‐ and 5.9‐fold greater than in the external medium. These results indicate that photorespiration is suppressed in both acid‐ and alkali‐grown cells by an intracellular accumulation of inorganic carbon due, in part, to an active uptake of bicarbonate.
Nucleotide sequence of a complete barley alcohol dehydrogenase 1 cDNA (1988)

Journal Article Nucleotide sequence of a complete barley alcohol dehydrogenase 1 cDNA Get access A.G. Good, A.G. Good Molecular Genetics Section, Plant Biotechnology InstituteNRC Canada, 110 Gymnasium Road, Saskatoon, Saskatchewan S7N 0W9, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar L.E. Pelcher, L.E. Pelcher Molecular Genetics Section, Plant Biotechnology InstituteNRC Canada, 110 Gymnasium Road, Saskatoon, Saskatchewan S7N 0W9, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar W.L. Crosby W.L. Crosby Molecular Genetics Section, Plant Biotechnology InstituteNRC Canada, 110 Gymnasium Road, Saskatoon, Saskatchewan S7N 0W9, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 16, Issue 14, 25 July 1988, Page 7182, https://doi.org/10.1093/nar/16.14.7182 Published: 25 July 1988 Article history Received: 20 June 1988 Published: 25 July 1988
17: Effects of growth/differentiation factor 5 (GDF5) on the induction and survival of midbrain dopaminergic neurons (2004)

Growth/differentiation factor 5 (GDF5) is a member of the transforming growth factor β (TGFβ) superfamily which has potent neurotrophic actions on nigrostriatal dopaminergic neurons, the pathway which degenerates in Parkinson's disease. Intracerebral administration of GDF5 has neuroprotective and regenerative effects on the 6-hydroxydopamine-lesioned nigrostriatal pathway in adult rats. Furthermore, treatment with GDF5 enhances the survival and function of grafted embryonic rat dopaminergic neurons in this adult rat model of Parkinson's disease. The roles of GDF5 in joint and limb development have been well documented, but there is little information about its functions in the developing or adult nervous system. We have found that GDF5 is expressed in the embryonic and adult rat brain. Its expression during brain development is temporally regulated. In the developing ventral mesencephalon (VM), the time-course of GDF5 expression parallels that of dopaminergic neuronal maturation, suggesting a role for this protein in dopaminergic neurogenesis or support. Furthermore, PCR analysis of a FACS-purified population of dopaminergic neurons from embryonic (E13.5) mouse VM showed that these cells express receptors for GDF-5. Exposure of E14 rat VM cultures to GDF5 induced significant increases in the number of dopaminergic [tyrosine hydroxylase (TH)-immunopositive] neurons in these cultures after 6 days in vitro (DIV), as well as improvements in the morphology of these cells. These actions of GDF5 were dependent on the presence of bone morphogenetic protein receptor (BMPR)-Ib, and were not mediated through glial cells. Treatment of E12 rat VM cultures with GDF5 increased the number of TH-immunopositive cells after 1 DIV. This effect was not due to proliferation of TH-positive cells already present in the culture or to a survival-promoting effect on these cells, suggesting that GDF-5 induced a dopaminergic phenotype in cells within these cultures. Treatment of expanded E12 rat VM neural progenitor cell cultures with GDF5 after 6 days of expansion for 24 h increased the expression of its receptors, BMPR-Ia, BMPR-Ib and BMPRII, and of the dopaminergic neuronal markers, Nurr-1 and TH. Pre-treatment with antibodies against BMPR-Ib prevented these increases in Nurr-1 and TH. This study suggests that GDF5 can induce a dopaminergic neuronal fate in uncommitted midbrain neural progenitor cells. Transplantation of dopaminergic neurons derived from neural stem and progenitor cells is being considered as a treatment for Parkinson's disease. Thus, information on molecules such as GDF5, which are capable of influencing progenitor cells towards adopting a doaminergic lineage, is critical to advancing this area of research.
Expression of the Transcription Factor Lung Kruppel-Like Factor Is Regulated by Cytokines and Correlates with Survival of Memory T Cells In Vitro and In Vivo (1999)

The transcription factor lung Krüppel-like factor (LKLF) is involved in naive T cell survival. Expression of LKLF is rapidly down-regulated upon T cell stimulation, raising the question of whether LKLF is reexpressed after activation, and what factors are required for such reexpression. Furthermore, the expression of LKLF in resting memory cells has not been determined. Here, we use the OT-I TCR transgenic mouse system to address these issues. LKLF was found to be reexpressed following culture of activated CD8 T cells in certain cytokines (IL-2, IL-7) but not others (IL-12) known to influence CTL development. Interestingly, induction of LKLF reexpression corresponded with long-term T cell survival and development of memory T cell phenotype. Furthermore, using OT-I cells stimulated in vivo, we demonstrated that Ag induced rapid LKLF down-regulation and that the factor is expressed by in vivo-derived memory T cells.
Impact of stress engineering on high-k metal gate ESD diodes in 32nm SOI technology (2009)

Low current and high current ESD characteristics of the Poly-Bounded and High-k Metal Gate-bounded ESD diodes with varying stress components are studied in 32nm SOI technology. It is observed that embedded SiGe (e-SiGe) stress on the anode degrades the ESD protection performance significantly mainly due to the introduction of defects in the active region. Compressive stress liners, tensile stress liners and stress due to Stress Memorization Technique (SMT) show only a marginal shift in the diode performance.
Influenza A Virus PB1-F2 Gene in Recent Taiwanese Isolates (2004)

Influenza A virus contains eight RNA segments and encodes 10 viral proteins. However, an 11th protein, called PB1-F2, was found in A/Puerto Rico/8/34 (H1N1). This novel protein is translated from an alternative open reading frame (ORF) in the PB1 gene. We analyzed the PB1 gene of 42 recent influenza A isolates in Taiwan, including 24 H1N1 and 18 H3N2 strains. One H1N1 isolate and 17 H3N2 isolates contained the entire PB1-F2 ORF of 90 residues, three amino acids (aa) longer than the PB1-F2 of A/Puerto Rico/8/34 at the C terminal. The one remaining H3N2 isolate encoded a truncated PB1-F2 with 79 residues. The other 23 H1N1 isolates contained a truncated PB1-F2 of 57 aa. Phylogenetic analysis of both the HA and the PB1 genes showed that they shared similar clustering of these Taiwanese isolates, suggesting that no obvious reassortment occurred between the two genomic segments.
Concepts of Osteoblast Growth and Differentiation: Basis for Modulation of Bone Cell Development and Tissue Formation (1992)

The combined application of molecular, biochemical, histochemical, and ultrastructural approaches has defined a temporal sequence of gene expression associated with development of the bone cell phenotype in primary osteoblast cultures. The peak levels of expressed genes reflect a developmental sequence of bone cell differentiation characterized by three principal periods: proliferation, extracellular matrix maturation and mineralization, and two restriction points to which the cells can progress but cannot pass without further signals. The regulation of cell growth and bone-specific gene expression has been examined during this developmental sequence and is discussed within the context of several unique concepts. These are (1) that oncogene expression in proliferating osteoblasts contributes to the suppression of genes expressed postproliferatively, (2) that hormone modulation of a gene is dependent upon the maturational state of the osteoblast, and (3) that chromatin structure and the presence of nucleosomes contribute to three-dimensional organization of gene promoters that support synergistic and/or antagonistic activities of physiologic mediators of bone cell growth and differentiation.
Matching and Record Linkage (1995)

This chapter contains sections titled: Terminology and Definition of Errors Improved Computer-Assisted Matching Methods Standardization and Parsing Matching Decision Rules Evaluating the Quality of Lists Estimation of Error Rates and Adjustment for Matching Error Computing Resources and Automation Concluding Remarks
Motion planning with sequential convex optimization and convex collision checking (2014)

We present a new optimization-based approach for robotic motion planning among obstacles. Like CHOMP (Covariant Hamiltonian Optimization for Motion Planning), our algorithm can be used to find collision-free trajectories from naïve, straight-line initializations that might be in collision. At the core of our approach are (a) a sequential convex optimization procedure, which penalizes collisions with a hinge loss and increases the penalty coefficients in an outer loop as necessary, and (b) an efficient formulation of the no-collisions constraint that directly considers continuous-time safety Our algorithm is implemented in a software package called TrajOpt. We report results from a series of experiments comparing TrajOpt with CHOMP and randomized planners from OMPL, with regard to planning time and path quality. We consider motion planning for 7 DOF robot arms, 18 DOF full-body robots, statically stable walking motion for the 34 DOF Atlas humanoid robot, and physical experiments with the 18 DOF PR2. We also apply TrajOpt to plan curvature-constrained steerable needle trajectories in the SE(3) configuration space and multiple non-intersecting curved channels within 3D-printed implants for intracavitary brachytherapy. Details, videos, and source code are freely available at: http://rll.berkeley.edu/trajopt/ijrr .
Front Matter and Table of Contents (1998)

This entry contains the front cover, front matter and back cover.
Posture in Patients With Shoulder Overuse Injuries and Healthy Individuals (1995)

Assessment of posture is an integral component of patient evaluation with shoulder overuse injuries. However, the professional literature contains relatively few studies that have assessed the relationship between posture, function, and injury. The purpose of this study was to determine the relationship and differences in postural variables within and between subjects with overuse injuries to the shoulder of healthy subjects. Thirty patient subjects and 30 healthy subjects matched for age and gender were recruited. Scapular protraction and rotation, forward head position, midthoracic curvature, and passive humeral elevation in the plane of the scapula were measured randomly in standing. All measurement techniques were standardized and validated. Intrarater and interrater reliability for all clinical measures were established before data collection. Forward head position was significantly greater (p < .001) in the patient group than the healthy group; humeral elevation was significantly greater (p < .001) in the healthy group than in the patient group and in the uninvolved shoulders (p < .01) than the involved shoulders within the patient group. Scapular protraction, rotation, midthoracic curvature, and scapular symmetry were not significantly different between groups. Scapula protraction and rotation were significantly related (p < .05) in the patient group. No other postural variables were related. Conclusions regarding the influence of posture to shoulder injury are inconclusive based on several confounding variables that may have affected the outcome.
Gremlin1 preferentially binds to bone morphogenetic protein-2 (BMP-2) and BMP-4 over BMP-7 (2014)

Gremlin (Grem1) is a member of the DAN family of secreted bone morphogenetic protein (BMP) antagonists. Bone morphogenetic protein-7 (BMP-7) mediates protective effects during renal fibrosis associated with diabetes and other renal diseases. The pathogenic mechanism of Grem1 during diabetic nephropathy (DN) has been suggested to be binding and inhibition of BMP-7. However, the precise interactions between Grem1, BMP-7 and other BMPs have not been accurately defined. In the present study, we show the affinity of Grem1 for BMP-7 is lower than that of BMP-2 and BMP-4, using a combination of surface plasmon resonance and cell culture techniques. Using kidney proximal tubule cells and HEK (human embryonic kidney)-293 cell Smad1/5/8 phosphorylation and BMP-dependent gene expression as readouts, Grem1 consistently demonstrated a higher affinity for BMP-2>BMP-4>BMP-7. Cell-associated Grem1 did not inhibit BMP-2- or BMP-4-mediated signalling, suggesting that Grem1-BMP-2 binding occurred in solution, preventing BMP receptor activation. These data suggest that Grem1 preferentially binds to BMP-2 and this may be the dominant complex in a disease situation where levels of Grem1 and BMPs are elevated.
Evidence that plasma lipoproteins inhibit the factor VIIa-tissue factor complex by a different mechanism that extrinsic pathway inhibitor (1987)

Factor VIIa participates in blood clotting by activating factor X and/or factor IX by limited proteolysis. The proteolytic activity of factor VIIa is absolutely dependent on a lipoprotein cofactor designated tissue factor. We have examined the ability of purified preparations of human plasma high density, low density and very low density lipoproteins, as well as apolipoproteins A-I and A-II, to inhibit the factor VIIa-tissue factor mediated activation of either factor X or factor IX before and after treatment of the lipoprotein preparation with polyclonal antibody directed against partially- purified human plasma extrinsic pathway inhibitor (EPI). In the absence of anti-EPI IgG, HDL, LDL, VLDL, and apolipoprotein A-II noncompetitively inhibited factor X activation by factor VIIa-tissue factor with apparent Ki values of 3.39 mumol/L, 124 nmol/L, 33 nmol/L, and 10.5 mumol/L, respectively. Apolipoprotein A-I had no effect on this reaction. The inhibitory activity of HDL, LDL, VLDL, and apolipoprotein A-II in this reaction was unaffected by the presence of high levels of anti-EPI IgG. In the absence of exogenous factor Xa, none of the lipoproteins studied inhibited the activation of factor IX using the tritiated peptide release assay. In the presence of added factor Xa (1 nmol/L), LDL and VLDL, but not HDL and apolipoprotein A- II, inhibited the activation of factor IX by factor VIIa-tissue factor. This inhibition was completely blocked by prior incubation of the lipoprotein with anti-EPI IgG indicating association of EPI with these particles. Taken collectively, our data indicate that HDL, LDL, and VLDL, at or below their plasma concentration, each selectively inhibits the factor VIIa-tissue factor mediated activation of factor X by a mechanism that appears to be distinct from extrinsic pathway inhibitor. These lipoproteins may not only play a role in the regulation of extrinsic blood coagulation, but may also selectively promote the activation of factor IX by factor VIIa-tissue factor in vivo at low tissue factor concentrations.
Inhibition of Coke Formation in Ethylene Steam Cracking (1983)

This paper describes the derivation and evaluation of a silica coating process to reduce the rate of coke formation in the pyrolysis section of ethylene steam crackers (ESC). The coating process utilises the chemical vapour deposition of an alkoxysilane in steam carrier gas to produce a thin, impervious, adherent and amorphous silica film on the internal surfaces of high alloy steel tubing at 700-800°C. Evaluation in a laboratory scale ethylene steam cracking reactor employing a typical ESC feedstock (LDF 160) has revealed that the coking rate can be reduced by up to x10 in short term tests and by x3-4 in longer term tests.