gebhart/patrepeval huggingface dataset:
Rhythmic ethylene production as affected by silver ions and as related to other rhythmic processes (1985)

Ethylene production by detached coty ledons of cotton (Gossypium hirsutum L.) seedlings grown under cycles of 12 h darkness and 12 h light has been shown to be rhythmic, with a minimum and maximum 4 and 16 h, respectively after the start of the cycle (Rikin, Chalutz and Anderson, 1984, Plant Physiol. 75, 493-495). Treatment with silver ions stimulated the rhythmic ethylene production in both regular and cycles (i.e. dark period changed to light period, and vice versa). The rate of the conversion of (3,4 14C)methionine into ethylene also followed the sti mulation of rhythmic ethylene evolution by silver ions in both regular and inverted cycles, while treat ment with aminoethoxyvinylglycine (AVG) de creased this stimulation. Conversion of exogenous 1-aminocyclopropane-l-carboxylic acid (ACC) in to ethylene was not affected by silver ions, but was dependent upon the immediate light conditions, regardless of the time in the light-dark cycle, light decreasing and darkness increasing this process. It is concluded that silver ions stimulate the normal rhythmic ethylene production, and this stimulation is regulated at a step prior to the conversion of ACC into ethylene. The rhythmicity in other processes (cotyledon movement, phenylalanine ammonia-lyase activity, resistance to the herbicide 3-isopropyl-l H-2,l,3-benzothiadiazin-4(3H)-one 2,2-dioxide (bentazon)) was not affected by a de crease in the rhythmic changes in ethylene produc tion by AVG or interference in ethylene action by silver ions. Thus, these rhythmic changes were not regulated by the rhythmic changes in ethylene production.
A fast staining-destaining method for SDS-PAGE which favours the recovery of protein (2000)

A fast staining destaining method for SDS PAGE which favours the recovery of proteins was developed :brief staining by Coomassie Brillant Blue R 250 followed by destaining with 250 mmol/L KCl.The SDS PAGE stained destained by this method has almost the same clearance compared with the one stained destained by the usual method,and the recovery of protein can be enhanced more than three times by this method.
Solving geometric constraint systems (1990)

Finding the configurations of a set of rigid bodies that satisfy a set of geometric constraints is a problem traditionally solved by reformulating the geometry and constraints as algebraic equations which are solved symbolically or numerically. But many such problems can be solved by reasoning symbolically about the geometric bodies themselves using a new technique called degrees of freedom analysis. In this approach, a sequence of actions is devised to satisfy each constraint incrementally, thus monotonically decreasing the system&apos;s remaining degrees of freedom. This sequence of actions is used metaphorically to solve, in a maximally decoupled form, the equations resulting from an algebraic representation of the problem. Degrees of freedom analysis has significant computational advantages over conventional algebraic approaches. The utility of the technique is demonstrated with a program that assembles and kinematically simulates mechanical linkages. Introduction Solving geometric con...
A Monoclonal Antibody for Molecular Diagnosis of Myxoid-Round Cell Liposarcoma (2007)

Advances in Anatomic Pathology: July 2007 - Volume 14 - Issue 4 - p 297 doi: 10.1097/PAP.0b013e3180ca8ac0
Conformational Analysis of Febrifugines and Halofuginones in Organic Solvents. (1998)

The stereostructures of anticoccidial agents, febrifugine and halofuginone, as well as the corresponding cis-isomers, in organic solvents were determined through NMR analyses, isomerization reactions and AM1 molecular orbital calculations.
Electrospun bioresorbable trileaflet heart valve prosthesis for tissue engineering: in vitro functional assessment of a pulmonary cardiac valve design. (2008)

Currently implanted prosthetic heart valves, both mechanical or biological ones, are used to restore the proper blood hemodynamics when the native valves fail. However, these medical devices are not free from drawbacks, such as hemolysis or calcification, also presenting the relevant disadvantage of being unable to growth, repair and remodel. An improvement could be represented by bioresorbable polymeric tissue-engineered heart valves. In this paper a poly(epsilon -caprolactone) (PCL) heart valve prosthesis, realized by means of electrospinning, and its in vitro functional characterization in a pulse duplicator, resembling pulmonary conditions, is presented. Morphological examination revealed polymeric micrometric fibers randomly oriented with an average porosity of about 90 percent. Pulse duplicator testing highlighted that leaflets opened synchronously and showed a correct coaptation in the diastolic phase, even if a slight rotation of the leaflets was visualized. In silico study by numerical simulation of the closed phase predicted the stress distribution within the leaflet, showing that peak levels are reached at the commissures and sustained by the structure without failure. The present study highlighted the technical feasibility to produce polymeric bioresorbable functional heart valves by means of electrospinning. Further studies and design changes are needed in order to optimize the final scaffold to bear arterial hemodynamic conditions.
Spatial and Temporal Error Concealment Techniques for Video Transmission Over Noisy Channels (2006)

Two novel error concealment techniques are proposed for video transmission over noisy channels in this work. First, we present a spatial error concealment method to compensate a lost macroblock in intra-coded frames, in which no useful temporal information is available. Based on selective directional interpolation, our method can recover both smooth and edge areas efficiently. Second, we examine a dynamic mode-weighted error concealment method for replenishing missing pixels in a lost macroblock of inter-coded frames. Our method adopts a decoder-based error tracking model and combines several concealment modes adaptively to minimize the mean square error of each pixel. The method is capable of concealing lost packets as well as reducing the error propagation effect. Extensive simulations have been performed to demonstrate the performance of the proposed methods in error-prone environments
An Efficient Process Live Migration Mechanism for Load Balanced Distributed Virtual Environments (2010)

Distributed virtual environments (DVE), such as multi-player online games and distributed simulations may involve a massive amount of concurrent clients. Deploying distributed server architectures is currently the most prevalent way of providing such large-scale services, where typically the virtual space is divided into several distinct regions requiring each server to handle only part of the virtual world. Inequalities in client distribution may, however, cause certain servers to become overloaded, which potentially degrades the interactivity of the environment and thus renders the load balancing problem a crucial issue. Prior research has shown several approaches for avoiding uneven workload, nevertheless, addressing the problem mainly at the application layer. In this paper we focus on solving the DVE load balancing problem at the operating system level. We propose an efficient process live migration mechanism, which is optimized for processes maintaining a massive amount of network connections. Building on top of it, we have implemented a decentralized middleware that instruments process migration among the cluster nodes, attempting to equalize loads on all machines. We demonstrate the performance of the live migration mechanism on a real-world multiplayer game server and show the behavior of the load balancing engine through a realistic DVE simulation.
Illudin S, the Sole Antiviral Compound in Mature Fruiting Bodies of <i>Omphalotus </i><i>i</i><i>lludens</i> (2003)

Crude extracts from the fruiting bodies of Omphalotus illudens displayed activity in the HSV-I/CV-1 antiviral assay. Bioactivity-guided isolation led to the known compound illudin S (1) as the sole antiviral component present in these extracts.
Facile Hydrolysis of the Trifluoromethyl Group in the Presence of Base. Some Trifluoromethylated Indoles (1957)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFacile Hydrolysis of the Trifluoromethyl Group in the Presence of Base. Some Trifluoromethylated IndolesJoseph Bornstein, Stephen A. Leone, William F. Sullivan, and O. Francis BennettCite this: J. Am. Chem. Soc. 1957, 79, 7, 1745–1748Publication Date (Print):April 1, 1957Publication History Published online1 May 2002Published inissue 1 April 1957https://pubs.acs.org/doi/10.1021/ja01564a058https://doi.org/10.1021/ja01564a058research-articleACS PublicationsRequest reuse permissionsArticle Views868Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Dramatic electrical conductivity improvement of carbon nanotube networks by simultaneous de-bundling and hole-doping with chlorosulfonic acid (2012)

An extremely high electrical conductivity, ∼1.7 × 106 S m−1, was obtained from the films that are made of de-bundled double-wall carbon nanotubes with chlorosulfonic acid (CSA). The influence of de-bundling four different carbon nanotubes with three different surfactants (CSA, N-methyl-2-pyrrolidone, and sodium dodecylbenzenesulfonate) on electrical conductivity and thermopower was compared and analyzed with electron micrographs and Raman spectra.
Nanoparticles for biomedical imaging (2009)

Structural design of nanomaterials for biomedical imaging continues to expand and diversify. Synthetic methods have aimed to control the size and surface characteristics of nanoparticles to control distribution, half-life and elimination. Although molecular imaging applications using nanoparticles are advancing into clinical applications, challenges such as storage stability and long-term toxicology should continue to be addressed.
Living with Hearing Difficulties: The process of enablement (2009)

Foreword by Richard Mabey. Preface. Acknowledgements. 1. Introduction. The need for this book. Terminology. Layout of the book. The World Health Organization classifications. Theoretical/management models in the general rehabilitation literature. Models of Audiological Enablement. The Goldstein-Stephens model. The role of Positive Experiences associated with hearing impairment. Relevant measures in assessing patients' needs and the outcomes of interventions. Development of a preliminary model appropriate to hearing impairment. Conclusion. 2. Seeking help. Introduction. Becoming aware of hearing difficulties. The decision to seek help. Referral for hearing help. Ethics/philosophy of adult screening. Conclusion. 3. Types of Hearing impairment and their consequences. Introduction. Basic anatomy and physiology and their implications. Purposes and process of assessment. Type of hearing impairment and their consequences . Severity of hearing impairment. Unilateral/asymmetrical hearing impairment. Age of onset. Genetic issues . Progressive/sudden onset. Conclusion. 4. The influence of other factors on assessment and goals of enablement. Introduction. Auditory symptoms. General Aural Symptoms. Vision. Cognitive and intellectual factors. Neuro-musculoskeletal problems. Conclusion. 5. Communication. Introduction. Ecological audiology. Ramsdell's classification. Attitudes of the Deaf. Conclusions. 6. Social and emotional aspects of hearing impairment. Introduction. Participation in life. Psychosocial dysfunction. Psychosocial consequences of Deafness. Demographic factors. Conclusion. 7. Hearing impairment in the family. Introduction. Impact of hearing impairment on significant others. Coping strategies. Inclusion of significant others in enablement programmes. Hearing impairment arising from genetic causes or with a familial basis. Impact of having a family history of hearing impairment. Discussion. Conclusion. 8. The process of enablement at work. Introduction. Statistics. Impact of hearing impairment on occupational performance. Impact of work related hearing impairment on significant others. Vocational Enablement. Vocational Enablement Protocol (VEP). Discussion. Conclusions. 9. Leisure and the wider social environment. Introduction. Prevalence. Solitary versus interactive pastimes. The role of leisure. Opportunities for entertainment and leisure . Community life. Recreation and leisure. Religion and spirituality. Human rights, political life and citizenship. Conclusions. 10. The process of enablement 1: Evaluation and decision making. Introduction. The Evaluation Process. Integration and decision making. Conclusions. 11. The process of enablement 2: Short-term remediation. Introduction. Instrumentation. Strategy. Ancillary Help. Conclusions. 12. Enablement 3: Ongoing remediation and Outcome assessment. Ongoing remediation. Effectiveness of group programmes. Outcome assessment. Conclusions. 13. Conclusions. Appendix - Longitudinal changes in enablement needs of older people with hearing impairment by Louise Hickson. References. Index.
ATP driven clathrin dependent entry of carbon nanospheres prefer cells with glucose receptors (2012)

The endocytosis of Glucose derived CSP into mammalian cells is an ATP dependent process mediated by clathrin coated pits. CSPs utilize the surface functional groups to target cells containing glucose transporters on its membrane thereby implicating a potential application for specific targeting of the brain or cancer cells.
Microwave multiplexers for space applications (1998)

The channel performance of a satellite payload is largely determined by the frequency response of its input and output multiplexers. This paper provides an insight into some of the requirements for these multiplexers and how they are met. An example of a simplified 12/14 GHz payload with key specification parameters for the multiplexers is given. The electrical design of the multiplexers is described and the mechanical, thermal and high-power aspects of their performance are discussed. State-of-the-art examples are given with typical computed and measured performance characteristics.
The effects of topical calcipotriol treatment on immune responses to vaccination (2008)

1,25-dihydroxyvitamin D3 (Vitamin D) is a potent immunomodulator capable of generating regulatory T cells (Tregs) and contributing to immune tolerance. Additionally, vitamin D has been shown to promote mucosal immunity when used as a vaccine adjuvant. We show here that pretreatment of an area of skin with the synthetic vitamin D analog calcipotriol combined with transcutaneous immunization results in the induction of CD4⁺CD25⁺ Tregs capable of inhibiting the elicitation of a contact hypersensitivity response. We also demonstrate that topical calcipotriol has significant effects on the immune response to subcutaneously injected vaccines, and compare it with another common topical immunosuppressant, the corticosteroid betamethasone-17-valerate (BMV). Functionally, calcipotriol and BMV treatment both result in the suppression of CD8⁺ T cell priming in response to subcutaneous vaccination, despite the topical co-administration of the potent Th1 inducing TLR9 agonist unmethylated CpG DNA. The effects of calcipotriol on the humoral response are subtler as we observe marginally increased production of antigen-specific IgG1 immunoglobulins along with a strong suppression of the IgG2a isotype. This is in contrast to pretreatment with BMV, which instead suppresses the production of IgG1 and IgA antibodies. In the draining lymph nodes of calcipotriol treated animals, we see no change in the percentage of Foxp3⁺ CD4⁺ T cells post-immunization, but show that tolerance is transferable with the adoptive transfer of CD4⁺CD25⁺ cells. Despite a decrease in the percentage of antigen-bearing APCs in the DLN of calcipotriol treated animals, the DCs maintain high expression of co-stimulatory markers and can induce CD4⁺ T cell proliferation ex vivo. Our data indicate that calcipotriol has distinct effects on immune responses to subcutaneous vaccines consistent with its role as an immunomodulator, although the mechanism(s) through which it is acting remain unclear. We believe that further research is warranted into its potential use as part of a treatment modality for allergy and autoimmune disorders.
Nouvelles inscriptions d'Iasos (1963)

Corrections, restitutions . et interprétations apportées à une trentaine d'inscriptions grecques récemment publiées et provenant de la ville d'Iasos sur la côte ouest de la Carie.
Primary analysis of a randomized, double-blind, phase II study of the anti-TIGIT antibody tiragolumab (tira) plus atezolizumab (atezo) versus placebo plus atezo as first-line (1L) treatment in patients with PD-L1-selected NSCLC (CITYSCAPE). (2020)

9503 Background: The immunomodulatory receptor TIGIT is a novel inhibitory immune checkpoint present on activated T cells and NK cells in multiple cancers, including NSCLC. In a phase I study (GO30103), co-inhibition of TIGIT and PD-L1 signaling with tira plus atezo in CIT-naïve PD-L1 positive NSCLC potentially improved overall response rates (ORR) compared to historical ORR with PD-L1/PD-1 inhibitors. We conducted this phase II trial to confirm the efficacy and safety of tira plus atezo (TA) compared to placebo plus atezo (PA) in 1L NSCLC (GO40290, NCT NCT03563716). Methods: This prospective, randomized, double-blind, placebo-controlled trial enrolled patients (pts) with chemotherapy-naïve PD-L1+ (TPS ≥ 1% by 22C3 IHC pharmDx Dako assay) locally advanced or metastatic NSCLC with measurable disease, ECOG PS 0-1, and without EGFR or ALK alterations. Pts were randomized 1:1 to TA (tira 600 mg IV plus atezo 1200 mg IV) or PA (placebo plus atezo 1200 mg IV) on day 1 of every 3-week cycle. Stratification factors were PD-L1 status (TPS ≥ 50% vs TPS 1-49%), histology, and tobacco history. Co-primary endpoints were investigator assessed ORR and PFS, and additional endpoints were duration of response (DOR), OS, and safety. Exploratory endpoints were the effect of PD-L1 status on ORR and PFS. Results: 135 pts were randomized to PA (n = 68) or TA (n = 67). At primary analysis (30 Jun 2019), TA improved ORR and median PFS (mPFS) compared to PA, with median follow-up of 5.9 mo. In the safety population (68 in PA, 67 in TA), treatment-related AEs (TRAEs) occurred in 72% (PA) and 80.6% (TA); Grade ≥3 TRAEs occurred in 19.1% (PA) and 14.9% (TA). AEs leading to treatment withdrawal occurred in 10.3% (PA) and 7.5% (TA). Clinical trial information: NCT03563716 . With an additional six months of follow-up since the primary analysis (2 Dec 2019, median follow-up of 10.9 mo), improvement in ORR and mPFS was maintained in ITT for TA (37.3% [25.0, 49.6] and 5.6 mo [4.2, 10.4]) vs PA (20.6% [10.2, 30.9] and 3.9 mo [2.7, 4.5]). The safety profile remained tolerable. Conclusions: Treatment with TA compared to PA showed clinically meaningful improvement in ORR and PFS in ITT. The safety profile of TA was similar to PA. [Table: see text]
MARINE-EXPRESS: taking advantage of high throughput cloning and expression strategies for the post-genomic analysis of marine organisms (2010)

The objective of this program was to get around the bottlenecks of soluble, active protein expression and crystallization for post-genomic validation of a number of proteins that come from various marine organisms. Multiplying the constructions, vectors and targets treated in parallel is important for the success of a medium throughput strategy and considerably increases the chances to get rapid access to pure and soluble protein samples, needed for the subsequent biochemical characterizations. Our set up of a medium throughput strategy applied to genes from marine organisms had a mean success rate of 44% soluble protein expression from marine bacteria, archaea as well as eukaryotic organisms. This success rate compares favorably with other protein screening projects, particularly for eukaryotic proteins. Several purified targets have already formed the base for experiments aimed at post-genomic validation.
GABA<sub>A</sub>receptor α4 subunits mediate extrasynaptic inhibition in thalamus and dentate gyrus and the action of gaboxadol (2006)

The neurotransmitter GABA mediates the majority of rapid inhibition in the CNS. Inhibition can occur via the conventional mechanism, the transient activation of subsynaptic GABAA receptors (GABAA-Rs), or via continuous activation of high-affinity receptors by low concentrations of ambient GABA, leading to "tonic" inhibition that can control levels of excitability and network activity. The GABAA-R alpha4 subunit is expressed at high levels in the dentate gyrus and thalamus and is suspected to contribute to extrasynaptic GABAA-R-mediated tonic inhibition. Mice were engineered to lack the alpha4 subunit by targeted disruption of the Gabra4 gene. alpha4 Subunit knockout mice are viable, breed normally, and are superficially indistinguishable from WT mice. In electrophysiological recordings, these mice show a lack of tonic inhibition in dentate granule cells and thalamic relay neurons. Behaviorally, knockout mice are insensitive to the ataxic, sedative, and analgesic effects of the novel hypnotic drug, gaboxadol. These data demonstrate that tonic inhibition in dentate granule cells and thalamic relay neurons is mediated by extrasynaptic GABAA-Rs containing the alpha4 subunit and that gaboxadol achieves its effects via the activation of this GABAA-R subtype.
Asymmetric Decarboxylative Allylation of Oxindoles (2011)

An asymmetric decarboxylative palladium-catalyzed allylation of alkyl- and aryl-substituted oxindoles has been developed, enabling the installation of an all-carbon quaternary chiral center at the oxindole 3-position in excellent yields and good to excellent enantioselectivity. An intriguing substrate-dependent reversal in stereoselectivity has been observed, whereby the size of the substituent determines the facial selectivity in the allylation step.
Demonstration of 1 Gbit/sec magnetic recording using an integrated inductive write/GMR read head (2000)

1 Gbit/sec magnetic recording was demonstrated with integrated inductive write/GMR read heads on a thin film disk with a coercivity of 3200 Oe and an Mrt of 0.34 memu/cm/sup 2/ with a spinstand tester. The write heads were made with high moment materials on both P1 and P2 and a densely packed coil using conventional manufacturing processes, and the read heads were made of dual synthetic spin valve sensor used for the 36 Gbit/in/sup 2/ areal density demonstration. The interconnect between the head and pre-amplifier is a pair of twisted wires of about 2 inch length. The demonstration was done at the outer diameter of the disk rotating at 15000 RPM. With a modest 35 mA (0-P) write current, we achieved an overwrite of about 30 dB and an on track error rate of better than 10/sup -7/. BER test on a disk with a coercivity of 4000 Oe also showed very good results.