gebhart/patrepeval huggingface dataset:
Noise in mixers, oscillators, samplers, and logic an introduction to cyclostationary noise (2002)

The proliferation of wireless and mobile products has dramatically increased the number and variety of low power, high performance electronic systems being designed. Noise is an important limiting factor in these systems. The noise generated is often cyclostationary. This type of noise cannot be predicted using SPICE, nor is it well handled by traditional test equipment such as spectrum analyzers or noise figure meters, but it is available from the new RF simulators. The origins and characteristics of cyclostationary noise are described in a way that allows designers to understand the impact of cyclostationarity on their circuits. In particular, cyclostationary noise in time-varying systems (mixers), sampling systems (switched filters and sample/holds), thresholding systems (logic circuitry), and autonomous systems (oscillators) is discussed.
Defining aggregations of the poor for community health center location. (1969)

Socioeconomic indexes based on multiple criteria of education, employment, and income are constructed and applied to Los Angeles County census data closely analyzed by area. Areas are classified by socioeconomic level of their residents, and large aggregations of the indigent and other groups are identified and delineated. Minimal assumptions about the function of community health centers permit estimation of their required number and best location to serve socioeconomic groups unable to obtain adequate health care privately.
Catabolism of L-Lysine by Pseudomonas aeruginosa (1977)

Pseudomonas aeruginosa PACI grows poorly on L-lysine as sole source of carbon but mutant derivatives which grow rapidly were readily isolated. Studies with one such mutant, P. aeruginosa PAC586, supported the existence of a route for L-lysine catabolism which differes from those reported previously in other species of Pseudomonas. The postulated route, the cadaverine or decarboxylase pathway, is initiated by the decarboxylation of L-lysine and involves the following steps: L-lysine leads to cadverine leads to I-piperideine leads 5-aminovalerate leads to glutarate semialdehyde leads glutarate. Evidence for this pathway is based on the characterization of the pathway reactions and the induction of the corresponding enzymes by growth on L-lysine. The first three enzymes were also induced by growth on cadaverine and to a lesser extent by 5-aminovalerate. No evidence was obtained for the presence of pathways involving L-lysine 2-monooxygenase or L-pipecolate dehydrogenase, but another potential route for L-lysine catabolism initiated by L-lysine 6-aminotransferase was detected. Studies with mutants unable to grow on L-lysine supported the existence of more than one catabolic pathway for L-lysine in this organism and indicated that all routes converge on a pathway for glutarate catabolism which generates acetyl-CoA. Pipecolate catabolism also appeared to converge on the glutarate pathway in P. AERUGINOSA. The results suggested that the growth rate of the parental strain is limited by the rate of transport and/or decarboxylation of L-lysine. The cadaverine pathway was present, but not so highly induced, in the parental strain P. aeruginosa PACI. Pseudomonas fluorescens contained enzymes of both the cadaverine (decarboxylase) and oxygenase pathways, strains of P. putida (biotypes A and B) contained enzymes of the oxygenase pathway but not the decarboxylase pathway and P. multivorans appeared deficient in both. All these species possessed L-lysine aminotransferase activity.
Spray-deposited ITO&#8212;Silicon SIS heterojunction solar cells (1980)

A systematic study of semiconductor-insulator-semiconductor (SIS) solar cells has been undertaken on n-type silicon using spray-deposited indium-tin-oxide (ITO) for the window layer of the heterostructure. The optical and electrical characteristics of the ITO layer as well as the thickness of the I layer have been optimized to yield the following photovoltaic parameters on 0.5-Ω . cm n-Si: <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">V_{OC} = 0.52</tex> V, <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">J_{SC} = 31.5</tex> mA/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> (adjusted for Ag grid area), <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">FF= 0.70</tex> , and illuminated area η = 11.5 percent. The dark <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">I-V</tex> and <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">C-V</tex> characteristics have also been evaluated to identify the mechanisms of barrier formation and current flow.
Enhancement of DES Algorithm with Multi State Logic (2014)

The principal goal to design any encryption algorithm must be the security against unauthorized access or attacks. Data Encryption Standard algorithm is a symmetric key algorithm and it is used to secure the data. Enhanced DES algorithm works on increasing the key length or complex S-BOX design or increased the number of states in which the information is to be represented or combination of above criteria. By increasing the key length, the number of combinations for key will increase which is hard for the intruder to do the brute force attack. As the S-BOX design will become the complex there will be a good avalanche effect. As the number of states increases in which the information is represented, it is hard for the intruder to crack the actual information. Proposed algorithm replace the predefined XOR operation applied during the 16 round of the standard algorithm by a new operation called “Hash function” depends on using two keys. One key used in “F” function and another key consists of a combination of 16 states (0,1,2…13,14,15) instead of the ordinary 2 state key (0, 1). This replacement adds a new level of protection strength and more robustness against breaking methods..
Hematopoietic Modulation by the Tachykinins (1997)

We have been studying hematopoietic effects by the tachykinins, which like many other neuropeptides can be expressed in neural and nonneural tissues. Substance P (SP) and neurokinin-A (NK-A), members of the tachykinins are immune and hematopoietic modulators. SP and NK-A are derived from the preprotachykinin-I gene (PPT-I) through alternate splicing and posttranslational modification. In the bone marrow (BM), nerve fibers provide a source of neural SP and the stroma provides a source of nonneural SP. The tachykinins interact with each of three cloned neurokinin (NK) receptors (NK-1R, NK-2R, NK-3R) with SP and NK-A exhibiting binding preferences for NK-1R and NK-2R, respectively. Proliferation of myeloid progenitors (CFU-GM) is differentially regulated by SP and NK-A. The former enhances the proliferation whereas the latter is inhibitory. The BM stroma mediates most of the hematopoietic effects exerted by SP and NK-A partly through the induction of cytokines. The proliferative effects of SP correlate with the induction of positive hematopoietic growth factors such as IL-3, IL-6, GM-CSF and c-kit ligand and the inhibitory effects by NK-A correlate with the induction of two negative hematopoietic regulators, MIP-1 alpha and TGF-beta. Intracellular signals mediated by NK-1R and NK-2R are part of the mechanism responsible for tachykinin-mediated regulation of hematopoiesis. The stimulatory effects on BM progenitors mediated by NK-1R can be partly inhibited by NK-2R activation. IL-1 and other cytokines induced by SP in BM stroma modulate NK-1R induction. Furthermore, SP can induce IL-1 type I receptor in stroma. Together, these data suggest that the tachykinins and the cytokines interact to regulate hematopoiesis. These interactions contribute to hematopoietic regulation by mechanisms that involve induction of: (1) tachykinins and cytokines by each other; (2) NK-1R by cytokines and (3) cytokine receptor by the tachykinins. These studies emphasize that in terms of hematopoiesis, the cytokines and neuropeptides are not mutually exclusive factors and thus, the hematopoietic regulatory network would be incomplete without the role of neuropeptides being considered.
Block of Ca <sup>2+</sup> Wave and Ca <sup>2+</sup> Oscillation by Antibody to the Inositol 1,4,5-Trisphosphate Receptor in Fertilized Hamster Eggs (1992)

The concentration of cytoplasmic free calcium (Ca2+) increases in various stimulated cells in a wave (Ca2+ wave) and in periodic transients (Ca2+ oscillations). These phenomena are explained by inositol 1,4,5-trisphosphate (IP3)-induced Ca2+ release (IICR) and Ca(2+)-induced Ca2+ release (CICR) from separate intracellular stores, but decisive evidence is lacking. A monoclonal antibody to the IP3 receptor inhibited both IICR and CICR upon injection of IP3 and Ca2+ into hamster eggs, respectively. The antibody completely blocked sperm-induced Ca2+ waves and Ca2+ oscillations. The results indicate that Ca2+ release in fertilized hamster eggs is mediated solely by the IP3 receptor, and Ca(2+)-sensitized IICR, but not CICR, generates Ca2+ waves and Ca2+ oscillations.
Discontinuous Monitoring of Propofol Concentrations in Expired Alveolar Gas and in Arterial and Venous Plasma during Artificial Ventilation (2006)

Propofol can be quantified in expired alveolar gas. The results stress the role of marked species-specific variability.
A colorimetric equipment for research on vision (1939)

Two spectra are formed by means of a dispersing system and dividing mirror. From one spectrum, two strips are reflected back through the dispersing system into a photometer prism to act as the instrument primaries, and from the other spectrum two strips are reflected back to provide a comparison field. The apparatus may be used as a trichromatic colorimeter or spectrophotometer, and for measurements on luminosity and on hue and saturation discrimination. Alternatively, the primaries can be viewed in the left eye and the comparison field in the right eye in order that the effects of adaptation may be measured by binocular matching. The observer's head can be fixed by means of a dental impression.
Reciprocal activating interaction between 6‐sulfo LacNAc<sup>+</sup> dendritic cells and NK cells (2008)

Dendritic cells (DCs) display an extraordinary capacity to induce T-cell responses providing the opportunity of DC-based cancer vaccination strategies. Additional findings indicate that DCs may also play a crucial role for the activation of natural killer (NK) cells, which are important effectors in innate antitumor immunity. However, studies investigating the interaction between native human DCs and NK cells are limited. Recently, we defined 6-sulfo LacNAc (slan) DCs as a major subpopulation of myeloid human blood DCs, which represent principal producers of the proinflammatory cytokines tumor necrosis factor-alpha and interleukin (IL)-12. Functional data revealed that slanDCs efficiently induce neoantigen-specific CD4+ T cells and activate tumor-reactive cytotoxic T cells. When evaluating the crosstalk between slanDCs and NK cells in this study, we found that lipopolysaccharide (LPS)-activated slanDCs efficiently enhance NK cell CD69 expression and interferon (IFN)-gamma secretion. NK cell-mediated tumor-directed cytotoxicity was significantly improved by slanDCs. NK cell activation induced by slanDCs was critically dependent on IL-12. When investigating the impact of NK cells on the immunostimulatory capacity of slanDCs, we observed that they promote DC maturation. In addition, NK cells strongly enhanced the secretion of immunomodulatory IL-12 and reduced the release of immunosuppressive IL-10 by slanDCs. IFN-gamma and cell-to-cell contact contributed to these effects. Furthermore, data revealed that DC-NK cell crosstalk improves slanDC-mediated differentiation of naïve CD4+ T lymphocytes into IFN-gamma-producing Th1 cells. In conclusion, we demonstrate a reciprocal activating interaction between slanDCs and NK cells, which may play a pivotal role in the regulation of antitumor immunity.
Sjøgren's syndrome-associated oxidative stress and mitochondrial dysfunction: Prospects for chemoprevention trials (2012)

An involvement of oxidative stress (OS) was found in recent studies of Sjøgren's syndrome (SS) that reported significant changes in protein oxidation, myeloperoxidase activity, TNF-α, nitrotyrosine, and GSH levels in plasma from SS patients. Excess levels of OS markers, as oxidative DNA damage and propanoyl-lysine, were reported in saliva from SS patients. Previous reports concurred with a role of OS in SS pathogenesis, by showing a decreased expression of antioxidant activities in conjunctival epithelial cells of SS patients and in parotid gland tissue samples from SS patients. A link between OS and mitochondrial dysfunction (MDF) is recognized both on the grounds of the established role of mitochondria in reactive oxygen species (ROS) formation and by the occurrence of MDF in a set of OS-related disorders. Earlier studies detected mitochondrial alterations in cells from SS patients, related to the action of antimitochondrial autoantibodies, and affecting specific mitochondrial activities. Thus, a link between MDF and OS may be postulated in SS, prompting studies aimed at elucidating SS pathogenesis and in the prospect of chemoprevention trials in SS clinical management.
Generation of Coherent cw-Terahertz Radiation Using a Tunable Dual-Wavelength External Cavity Laser Diode (1999)

A tunable dual-wavelength external cavity laser diode (2-λ-ECL) was used to generate tunable coherent cw-terahertz (THz) radiation by photomixing in a biased photoconductive antenna fabricated on a low-temperature-grown (LTG)-GaAs film. The 2-λ-ECL oscillated at the two output modes simultaneously with a frequency separation from 250 GHz to 2.1 THz in the same cavity. We demonstrated that the frequency of the emitted THz radiation corresponded to the difference frequency between the two modes of the diode laser. The tunable 2-λ-ECL, due to its compact design and ease of optical alignment, is a promising laser source for the generation of tunable cw-THz radiation by photomixing.
On the Role of NVRAM in Data-intensive Architectures: An Evaluation (2012)

Data-intensive applications are best suited to high-performance computing architectures that contain large quantities of main memory. Creating these systems with DRAM-based main memory remains costly and power-intensive. Due to improvements in density and cost, non-volatile random access memories (NVRAM) have emerged as compelling storage technologies to augment traditional DRAM. This work explores the potential of future NVRAM technologies to store program state at performance comparable to DRAM. We have developed the PerMA NVRAM simulator that allows us to explore applications with working sets ranging up to hundreds of gigabytes per node. The simulator is implemented as a Linux device driver that allows application execution at native speeds. Using the simulator we show the impact of future technology generations of I/O-bus-attached NVRAM on an unstructured-access, level-asynchronous, Breadth-First Search (BFS) graph traversal algorithm. Our simulations show that within a couple of technology generations, a system architecture with local high performance NVRAM will be able to effectively augment DRAM to support highly concurrent data-intensive applications with large memory footprints. However, improvements will be needed in the I/O stack to deliver this performance to applications. The simulator shows that future technology generations of NVRAM in conjunction with an improved I/O runtime will enable parallel data-intensive applications to offload in-memory data structures to NVRAM with minimal performance loss.
Synchronization in Distributed Programs (1982)

A technique for solving synchronization problems in distributed programs is described. Use of this technique in environments in which processes may fail is discussed. The technique can be used to solve synchronization problems directly, to implement new synchronization mechanisms (which are presumably well suited for use in distributed programs), and to construct distributed versions of existing synchronization mechanisms. Use of the technique is illustrated with implementations of distributed semaphores and a conditional message-passing facility.
OGG1 Mutations and Risk of Female Breast Cancer: Meta-Analysis and Experimental Data (2015)

In first part of this study association between OGG1 polymorphisms and breast cancer susceptibility was explored by meta-analysis. Second part of the study involved 925 subjects, used for mutational analysis of OGG1 gene using PCR-SSCP and sequencing. Fifteen mutations were observed, which included five intronic mutations, four splice site mutations, two 3'UTR mutations, three missense mutations, and a nonsense mutation. Significantly (p < 0.001) increased (~29 fold) breast cancer risk was associated with a splice site variant g.9800972T>G and 3'UTR variant g.9798848G>A. Among intronic mutations, highest (~15 fold) increase in breast cancer risk was associated with g.9793680G>A (p < 0.009). Similarly ~14-fold increased risk was associated with Val159Gly (p < 0.01), ~17-fold with Gly221Arg (p < 0.005), and ~18-fold with Ser326Cys (p < 0.004) in breast cancer patients compared with controls, whereas analysis of nonsense mutation showed that ~13-fold (p < 0.01) increased breast cancer risk was associated with Trp375STOP in patients compared to controls. In conclusion, a significant association was observed between OGG1 germ line mutations and breast cancer risk. These findings provide evidence that OGG1 may prove to be a good candidate of better diagnosis, treatment, and prevention of breast cancer.
Ablation of Tumor-Derived Stem Cells Transplanted to the Central Nervous System by Genetic Modification of Embryonic Stem Cells with a Suicide Gene (2007)

Embryonic stem cell (ESC)-based therapies open new possibilities as regenerative medicine for the treatment of human disease, but the presence of small numbers of undifferentiated ESCs within the transplant could lead to the development of tumors. The safety of ESC transplants would be enhanced if uncontrolled cell growth could be suppressed, using external stimuli. A lentiviral vector carrying the herpes simplex virus thymidine kinase (HSVtk) and green fluorescent protein (GFP) genes was used to genetically modify murine ESCs (HSVtk+GFP+ ESCs). In the presence of ganciclovir (GCV), 100% of HSVtk+GFP+ ESCs were killed in vitro, and 100% of flank tumors derived from HSVtk+GFP+ ESCs were eliminated. When CNS tumors were produced by the HSVtk+GFP+ ESCs, the tumor mass was completely eliminated on GCV treatment for 1 week. After GCV treatment for 3 weeks, histologic analysis showed no residual tumor cells and TaqMan realtime polymerase chain reaction analysis showed no genomic HSVtk copies or HSVtk mRNA. These data demonstrate that it is possible to use ex vivo gene transfer to modify ESCs with conditional genetic elements that can be activated in vivo to control undifferentiated ESC outgrowth and to eliminate transduced ESCs that have escaped growth control after ESC-mediated therapy to the CNS.
Long-Term Treatment of Trichotillomania (Hair Pulling) (1993)

To the Editor: In 1989 we reported that clomipramine was superior to desipramine in reducing hair-pulling symptoms in trichotillomania1. Three of the 13 subjects completing the initial double-blind...
Controlled Synthesis of Siloxane Copolymers Having an Organosulfur Group by Polymerization of Cyclotrisiloxanes with Mixed Units (1996)

The preparation of poly(dimethylsiloxane)s having part of the siloxane units substituted with a model organic thioether was investigated. The sulfur group was generated by the ene−thiol addition to the vinyl function bound to silicon. Two synthetic routes to this copolymer were compared (i) one-step kinetically controlled polymerization of organosulfur-substituted hexamethylcyclotrisiloxane and (ii) two-step synthesis including kinetically controlled polymerization of 1,3,3,5,5-pentamethyl-1-vinylcyclotrisiloxane followed by the thiol addition to the vinyl group in the polymer. A cryptand−lithium silanolate complex generated from [(trimethylsilyl)methyl]lithium was selected as the initiator in this polymerization, while tert-butyl mercaptan was used as the hydrosulfidation reagent. It was shown that synthesis routes lead to a high yield of copolymers having a fairly regular chain structure. The arrangement of siloxane units in the polymer chain was controlled by the propagation step. Polymerization of the vinyl-substituted monomer exhibited a significant degree of regioselectivity as one of the three possible modes of the monomer ring opening contributed over 70% to the propagation. Addition of t-BuSH to the vinyl group in the polymer proceeded without rearrangement of the polymer chain and could be performed without any side reaction of the vinyl group. Model copolymers of regular alternating structure were synthesized by the heterofunctional polycondensation of [2-(tert-butylthio)ethyl]methyldichlorosilane with a series of diols, HO(Me2SiO)nH, n = 1−4. They were used for comparison with the copolymers obtained by ring-opening polymerization.
Anti-inflammatory and anti-coagulatory activities of caffeic acid and ellagic acid in cardiac tissue of diabetic mice (2009)

These results support that CA and EA could provide triglyceride-lowering, anti-coagulatory, anti-oxidative, and anti-inflammatory protection in cardiac tissue of diabetic mice. Thus, the supplement of these agents might be helpful for the prevention or attenuation of diabetic cardiomyopathy.
Prescriptive Modeling and Compensation of In-Plane Shape Deformation for 3-D Printed Freeform Products (2016)

Although 3-D printing or additive manufacturing (AM) holds great promise as a direct manufacturing technology, the geometric accuracy of AM built products remains a critical issue, especially for freeform products with complex geometric shapes. Efforts have long been attempted to improve the accuracy of AM built freeform products. But there is a lack of generic and prescriptive methodology transparent to specific designs and AM processes. This paper fills the gap by establishing the methodology to predict and compensate the in-plane (x - y plane) geometric deformation of AM built freeform products based on a limited number of simple trial shapes. Built upon our previous predictive model and optimal compensation study for the cylinder and polyhedron shapes, this paper makes a breakthrough by directly controlling arbitrary freeform shape deformation from computer-aided design. Experimental investigation using stereolithography process successfully validates the proposed prescriptive modeling and compensation methodology. This paper provides the prospect of proactively improving printing accuracy of arbitrary products built by a variety of AM processes.