gebhart/patrepeval huggingface dataset:
Parallelizable microfluidic dropmakers with multilayer geometry for the generation of double emulsions (2019)

Microfluidic devices enable the production of uniform double emulsions with control over droplet size and shell thickness. However, the limited production rate of microfluidic devices precludes the use of monodisperse double emulsions for industrial-scale applications, which require large quantities of droplets. To increase throughput, devices can be parallelized to contain many dropmakers operating simultaneously in one chip, but this is challenging to do for double emulsion dropmakers. Production of double emulsions requires dropmakers to have both hydrophobic and hydrophilic channels, requiring spatially precise patterning of channel surface wettability. Precise wettability patterning is difficult for devices containing multiple dropmakers, posing a significant challenge for parallelization. In this paper, we present a multilayer dropmaker geometry that greatly simplifies the process of producing microfluidic devices with excellent spatial control over channel wettability. Wettability patterning is achieved through the independent functionalization of channels in each layer prior to device assembly, rendering the dropmaker with a precise step between hydrophobic and hydrophilic channels. This device geometry enables uniform wettability patterning of parallelized dropmakers, providing a scalable approach for the production of double emulsions.
Alterations of Glutamate, Glutamine, and Related Amino Acids in the Anterior Eye Secondary to Ischaemia and Reperfusion (2012)

We propose a model to explain the maintenance of amino acid homeostasis in the aqueous humour despite altered levels in both the ciliary processes and lens.
Affective and Cognitive Effects of Option in an Educational Setting (1975)

Option, found to have enhanced academic performance and attitudes of high school Ss, was reexamined using 811 fifth and sixth graders. Choices of study booklets on a 2-week vocabulary unit resulted in lower learning and retention scores than those obtained in a control where booklets were assigned to students. The affective measures of liking and perceived learning were not significantly affected by option. A model accounting for both positive and negative effects of option is proposed and discussed. Assuming performance is generally a positive linear function of task importance, the model postulates that task-importance under option is a function of the substantialness and expectancy of the option.
Immunohistochemistry in the diagnosis of the gestational trophoblastic disease (1996)

Our study proves immunohistochemistry as useful tool for differential diagnosis in borderline cases of gestational trophoblastic disease.
[Effects of the autonomic nervous system in supraventricular arrhythmia]. (1986)

Influences of the autonomic nervous system may cause modifications of the initiation, continuation and discontinuation of supraventricular rhythm disturbances. Whether or not clinically relevant bradycardia syndromes (such as the hypersensitive carotid sinus syndrome and the sick sinus syndrome) also may exist primarily on a functional basis, remains to be proven. Organic pathology, whether it is clinically apparent or not, probably provides the basis for the activation of influences on the autonomic nervous system. In atrial fibrillation and atrial flutter the influence of the autonomic nervous system is apparent in a form of the vagotonically and sympathotonically evoked paroxysms. In the case of persistent atrial fibrillation vagal and sympathotonically transmitted changes in the AV-dromotropy determine the mode of heart rate. Junctional re-entry tachycardias and re-entry tachycardias under the influence of accessory pathways, are potentially triggered by mechanisms, as transmitted by the autonomic nervous system. Furthermore, such autonomic influences are responsible for changes in the conducting velocity and the refractory properties, as produced by parallel conducting pathways. Hemodynamic changes themselves, which are induced at the very beginning of the tachycardia, may activate other electrophysiological mechanisms and thereby cause a modification in the type of tachycardia in question.
Clinical illness associated with a commercial tick and flea product in dogs and cats. (1991)

A commercial flea and tick product containing 9.0% fenvalerate for use in dogs and cats was suspected of causing illness. An acute toxicity study was performed in 10 dogs and 10 cats exposed to the product orally (po) and dermally at differing doses. Samples were obtained for DEET and fenvalerate analysis. Oral dosing of dogs and cats produced severe clinical illness at doses as low as 0.66% of a can (7 ounce spray can)/kg body weight. Dermal application of the product resulted in minor clinical abnormalities in dogs. Oral exposure at 0.5% can/kg body weight resulted in severe illness, and dermal application caused severe illness or death in cats at 20% and 40% of a can/kg body weight. The cats receiving 10% of a can/kg body weight dermally became depressed for several hours but recovered uneventfully. Serum DEET concentrations closely paralleled the clinical signs observed in the animals. Serum concentrations of DEET above 20 ppm were considered diagnostic for intoxication. Urine concentrations of DEET above 1 ppm and tissue (liver, bile, and kidney) concentrations of DEET above 10 ppm were supportive of poisoning; values near 100 ppm were diagnostic for fatal poisoning.
Non‐coeliac gluten sensitivity: piecing the puzzle together (2015)

The avoidance of wheat- and gluten-containing products is a worldwide phenomenon. While coeliac disease is well-established, much remains unknown about whether gluten can be a trigger of gastrointestinal and/or extra-intestinal symptoms in patients without coeliac disease. In this article, we discuss the latest scientific evidence and our current understanding for the possible mechanisms of this largely ambiguous group, termed 'non-coeliac gluten sensitive' (NCGS). We can conclude that NCGS should be regarded as an independent disease outside of coeliac disease and wheat allergy, and that the number of patients affected is likely to be limited. Many questions remain unanswered and it needs to be verified whether the elimination of dietary gluten alone is sufficient for the control of symptoms, and to understand the overlap with other components of wheat.
COVID-19 Deaths Previsions With Deep Learning Sequence Prediction (2020)

In this study, the authors use deep learning sequence prediction models for the continuous monitoring of the epidemic while considering the potential impacts of Bacille Calmette-Guérin (BCG) vaccination and tuberculosis (TB) infection rates in populations. Three models were built based on the epidemic data evolution in several countries between the date of their first case and April 1, 2020. The data was based on 14 variables for cases prediction, 15 variables for recoveries prediction, and 16 variables for deaths prediction. Prevision results were very promising, and the suspicions on the BCG vaccination and TB infections rates' implications turned out to be warranted. The model can evolve by continuously updating and enriching data, adding the experiences of all affected countries.
Skin Lesion Classification Using CNNs With Patch-Based Attention and Diagnosis-Guided Loss Weighting (2019)

The proposed methods improve automatic skin lesion classification. They can be extended to other clinical applications where high-resolution image data and class imbalance are relevant.
A Geometrical Active Contour Based on Statistical Shape Prior Model (2008)

A new geometric active contour based level-sets model combining gradient, region and shape knowledge information cues is proposed to robust object detection boundaries in presence of occlusions and cluttered background. The gradient, region and shape knowledge information are incorporated as energy terms. The a priori shape model is based on statistical learning of the training data distribution where the structure of data distribution is approximated by a probability density model. The obtained probability is treated as Kernel Principal Component Analysis (KPC) by allowing the shapes that are close to the training data as energy term and incorporated a prior knowledge about shapes in a more robust manner into evolving equation model to constrain the further segmentation evolution process. We applied successfully the proposed model to synthetic and real MR images. The results drawn by the newer model are compared to expert segmentation and evaluated in terms of F-mesure.
Analysis and Design of Panoramic Stereo Vision Using Equi-Angular Pixel Cameras (1999)

In this report we discuss methods to perform stereo vision using a novel configuration of devices that allow imaging of a very wide field of view (full 360 degrees in the azimuth and up to 120 degrees in elevation). Since the wide field of view produces signficant distortion that varies with viewpoint, we have developed a method to do correlation matching and triangulation for stereo vision that incorporates mirror shape. In this report we evaluate various configurations of cameras and mirrors that could be used to produce stereo imagery, including one that can use a single camera to produce stereo images. Range from panoramic stereo imagery can be used in many applications that require the three dimensional shape of the world. The chief advantages of this method is that it can made cheaply with no moving parts and can provide dense range data. Specifically, this kind of a sensor could be used for telepresence, autonomous navigation by robots, automatic mapping of environments and atti...
The B4 lectin from Vicia villosa seeds interacts with N-acetylgalactosamine residues alpha-linked to serine or threonine residues in cell surface glycoproteins. (1983)

We have examined the carbohydrate binding specificity of the B4 lectin from Vicia villosa seeds. The B4 lectin agglutinates Tn-exposed erythrocytes specifically and binds to these erythrocytes (1.4 X 10(6) sites/cell) with an association constant of 4.2 X 10(7) M-1. The concentrations of saccharides and glycopeptides of defined structure which cause 50% inhibition of B4 lectin binding to Tn-exposed erythrocytes were determined. N-Acetylgalactosamine is the best monosaccharide inhibitor, causing 50% inhibition of binding at a concentration of 0.04 mM. Other monosaccharides inhibit lectin binding in the following order of decreasing potency: N-acetylgalactosamine greater than methyl-alpha-galactopyranoside greater than p-nitrophenyl-alpha- or beta-galactopyranoside greater than methyl-beta-galactopyranoside, galactose greater than galactosamine greater than mannose, N-acetylglucosamine. The disaccharide Gal beta 1,3GalNAc causes 50% inhibition of binding at a concentration of 2.8 mM, a concentration similar to that of the p-nitrophenyl-alpha- or beta-galactopyranosides. Glycopeptides containing O-glycosidically linked oligosaccharide units are significantly more potent inhibitors of lectin binding than the oligosaccharide units alone. The most potent glycopeptide inhibitor is a fetuin glycopeptide containing two alpha-linked N-acetylgalactosamine units. This glycopeptide causes 50% inhibition of lectin binding at a concentration of 0.00034 mM and probably closely resembles the B4 lectin binding site on Tn-exposed erythrocytes.
Robust recognition and pose determination of 3-D objects using range images in eigenspace approach (2002)

In this paper we propose a robust method for recognition and pose determination of 3-D objects using range images in the eigenspace approach. Instead of computing the coefficients by a projection of the data onto the eigenimages, we determine the coefficients by solving a set of linear equations in a robust manner. The method efficiently overcomes the problem of missing pixels, noise and occlusions in range images. The results show that the proposed method outperforms the standard one in recognition and pose determination.
Venezuela: um projeto civilizador para uma nação mestiça (2002)

Projetos políticos e identidades nacionais na América Ibérica, explicitamdiferentes abordagens de um recorrente elemento. A questão da mestiçagem éreferência obrigatória observada na constituição dos projetos de (re)construçãodas nações e dos nacionalismo também na Venezuela na primeira metade doséculo XX, em momento em que se nega, se repudia ou se resgata elementosde uma nacionalidade pre-existente, para a nova construção, onde se buscaintroduzir outros e novos elementos, (re)articulando-os entre si.
User Interface Prototypes for Social Ad Hoc Networking (2013)

WLAN technology available in everyday handheld devices conforming to the IEEE 802.11 standard includes ad hoc networking mode. The use of ad hoc networking enables devices to communicate directly with each other, without the need for external infrastructure or Internet connection. The technology has not gained popularity, as there has been a lack of a driving application. This thesis presents user interfaces and use cases for TWIN, a social application using mobile ad hoc networking. TWIN has been developed at the Tampere University of Technology, Department of Computer Systems, in cooperation with Nokia Research Center. TWIN enables users to find other physically nearby users, form social groups, share media and send messages.\nThis thesis also presents methods used to accomplish fast prototyping and iterative development to be able to experiment with new features and ideas. Problems related to evaluation and testing of graphical user interfaces are also discussed. The main results of the thesis are the design of use cases and user interfaces, and the implementation of those interfaces in TWIN. Secondary results presented here are the evaluation of the use cases and user interfaces, and the evaluation of methods used for fast prototyping and testing of the application.
Glycopeptide N-acetylgalactosaminyltransferase specificities for O-glycosylated sites on MUC5AC mucin motif peptides (2001)

The recombinant proteins of the two novel UDP-N-acetylgalactosamine (GalNAc) glycopeptide:N-acetylgalactosaminyltransferases (designated gpGaNTase-T7 and gpGaNTase-T9) were assayed with O-glycosylated products obtained from the prior action of the ubiquitous transferases (GaNTase-T1 and GaNTase-T2) towards MUC5AC mucin motif peptides (GTTPSPVPTTSTTSAP and peptides with single amino acid substitutions, GTTPSAVPTTSTTSVP and GTTPSPVPTTSITSVP, that are a reflection of mucin molecule polymorphism). gpGaNTase-T9 is known to be expressed differentially and more abundantly than gpGaNTase-T7 in some tissues; the results of in vitro glycosylation also indicates a difference in acceptor substrate specificities between the gpGaNTase isoforms. With the use of capillary electrophoresis, MS and Edman degradation, our study suggests that, in the O-glycosylation of mucin-type proteins, approach and recognition signalling by gpGaNTase-T7 and gpGaNTase-T9 depend largely on the peptide's primary structure (for example the presence of multiple clusters of hydroxy amino acids and the number of GalNAc residues attached to the peptide backbone). O-glycosylation in terms of sites of attachment seems to be less random than previously described and, if sequential reactions are ordered throughout the Golgi stack, the complete O-glycosylation of the mucin molecules seems to be finely tuned to respond to specific damage to, or attack on, epithelia.
G894T Polymorphism in the Endothelial Nitric Oxide Synthase Gene Is Associated With an Enhanced Vascular Responsiveness to Phenylephrine (1999)

Background —Differences in vascular reactivity to phenylephrine (PE) responsiveness have been largely evidenced in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB). Because nitric oxide (NO) strongly affects modulation of the vascular tone in response to vasopressor agents, we hypothesized that the G894T polymorphism of the endothelial NO synthase gene ( eNOS ) could be related to changes in the pressor response to PE. Methods and Results —The protocol was performed in 68 patients undergoing coronary artery bypass grafting (n=33) or valve surgery (n=35) in whom mean arterial pressure decreased below 65 mm Hg during normothermic CPB. Under constant and nonpulsatile pump flow conditions (2 to 2.4 L · min −1 · m −2 ), a PE dose-response curve was generated by the cumulative injection of individual doses of PE (25 to 500 μg). The G894T polymorphism of the eNOS gene was determined, and 3 groups were defined according to genotype (TT, GT, and GG). Groups were similar with regard to perioperative characteristics. The PE dose-dependent response was significantly higher in the allele 894T carriers (TT and GT) than in the homozygote GG group ( P =0.02), independently of possible confounding variables. Conclusions —These results evidenced an enhanced responsiveness to α-adrenergic stimulation in patients with the 894T allele in the eNOS gene.
Automated Detection of Complex Fractionated Atrial Electrograms In Substrate-Based Atrial Fibrillation Ablation: Better Discrimination with a New Setting of CARTO® Algorithm. (2013)

<b>Background and purpose:</b> Up until recently complex fractionated atrial electrogram (CFAE) ablation has been considered as time consuming and its achievement as challenging, especially for non experimented operators. Moreover, results of substrate ablation based on CFAE detection in atrial fibrillation (AF) are very disparate, mainly because of the operator's subjective electrogram visual analysis and the difficult distinction between CFAEs really involved in AF perpetuation from other CFAE. Automatic detection provided by 3D mapping system (CARTO® algorithm) can be helpful but is not selective enough, drawing too wide CFAE areas. We sought to demonstrate a better selectivity of a new CFAE algorithm setting in order to better discriminate CFAEs really involved in AF perpetuation from other CFAE. <b>Methods and subjects:</b> A population of 32 patients (60.4±12.7 years) with paroxysmal (n=3) AF (PAF), persistent (n=16) AF (PeAF) or long-standing persistent (n=13) AF (LSPeAF), and AF history =56±65 months, underwent CFAE ablation based on visual analysis. Before ablation, left atrium CFAE mapping was performed on CARTO® shortest complex interval (SCI) algorithm and reanalyzed after ablation with the two different settings: nominal (SCI 60-120ms/0.05-0.15mV) vs. customized setting (SCI 30-40ms/0,04-0.15mV). CFAE areas automatically detected by both settings (CFAE-CARTO® areas) were respectively measured. The decision to ablate CFAE was only based upon the operator's electrogram visual analysis taken as reference because of high AF termination rate (93.7%) due to operator's CFAE selection experience. These ablation points drawn reference-CFAE areas involved in AF perpetuation (ablation point=60mm<sup>2</sup>) allowing to compare the selectivity of the two previous automatic maps. <b>Results:</b> With the customized CARTO® SCI setting, we observed a significant reduction of CFAE areas detected by CARTO® (CFAE-CARTO® areas) and of the ablated CFAE surface inside non-CFAE CARTO® areas, (30.6±20.5cm2 vs. 68.8±24.5cm2, p<0.0001, and 1.86±1.82% vs. 3±3%, p=0.003). Furthermore the proportion of ablated areas/detected CFAE-CARTO® areas were higher with customized setting (38.2±19.6% vs. 20.4±17.5%, p=0.008). <b>Conclusions:</b> This new customized CFAE algorithm setting is significantly more selective than the nominal one and allows an automated detection of CFAE really involved in AF perpetuation truer to an efficient experienced operator's electrogram visual analysis.
Studies in ferrocene derivatives. IX. The dimerization of α-ferrocenyl carbonium ions (1970)

Ferrocenylethylenes dissolve in 90% HCOOH to give solutions of the α-ferrocenyl carbonium ions in equilibrium with the unprotonated species. These subsequently react by an ionic-addition mechanism to give dimeric carbonium ions which can cyclize by both homo-and heteroannular pathways.
Investigation of methods to extract TDOA from UWB-IR waveforms (2010)

By using the Time-Difference-of-Arrival (TDOA) of UWB-IR waveforms at multiple antennas, the position of a transmitting tag can be accurately estimated for high precision positioning applications. Several methods can be used to obtain the TDOA information based on the knowledge of the received waveforms at the antennas. The performance of the various methods however depend on the quality of the received signals. In this paper, the performance of some of the methods (peak detection, leading edge detection, envelope detection, cross correlation detection and use of template waveforms) are experimentally evaluated by using them to derive the TDOA information from the measured waveforms. The derived TDOA information is compared with the actual TDOA and from there, the strengths and weaknesses of each method are discussed.
Influence of 17β-Estradiol and Progesterone on Rat Ocular Lens (1995)

The effect of 17 beta-estradiol and progesterone on ocular lens in rats and untreated controls was studied. In the treated lenses, the activity of hexokinase and glucose-6-phosphate dehydrogenase remained unchanged. The activity of aldolase was increased in 18- and 20-month-old lenses as compared to controls. Aldose reductase activity was decreased at the age of 20 months (p < 0.001). Structural lens proteins studies by SDS polyacrylamide gel electrophoresis and immunodecoration with specific antibodies for crystallines alpha A + alpha B and beta + gamma suggest some protective effect in treated animals.
The Relationship of Online Customer Value, Satisfaction, and Loyalty: An Empirical Study (2004)

In this study, we propose a three-component customer value model for ecommerce.This model draws upon the literature in marketing, consumer study, and information systems.It decomposes customer value into process value, outcome value, and shopping enjoyment.This three-component model is parsimonious and comprehensive.The results from this study show that outcome value and process value contribute significantly to customer satisfaction.Evidences also suggest that customer satisfaction affects loyalty.Enjoyment, however, has no significant positive impact on customer satisfaction.Explanations are presented in discussions and implications.
Antimalarial drugs. 38. Folate antagonists. 10. Synthesis and antimalarial effects of 6-[[(aryl and aralkyl)amino]methyl]-2,4-pteridinediamines and -pteridinediamine 8-oxides (1978)

Various 6-[[(aryl and aralkyl)amino]methyl]-2,4-pteridinediamines and their 8-oxides have been synthesized for antimalarial evaluation. Condensation of 3-amino-6-(bromomethyl)-2-pyrazinecarbonitrile 4-oxide (V) with the appropriately substituted amine afforded a series of 3-amino-6-[[(aryl and aralkyl)amino]methyl]-2-pyrazinecarbonitrile 4-oxides VI. Deoxygenation gave the corresponding pyrazines VII. Cyclization of VI and VII with guanidine then produced the desired 6-(aminomethyl)-2,4-pteridinediamine N-oxides VIII and teridinediamines IX, respectively. Formylation of 6-[[(3,4-dichlorophenyl)amino]methyl]-2,4-pteridinediamine gave N-[(2,4-diamino-6-pteridinyl)-methyl]-N-(3,4-dichlorophenyl)formamide. The N-oxides VIII did not exhibit significant activity against Plasmodium berghei infections in mice. Activity among the 2,4-pteridinediamines IX was generally poor with the exception of the 3,4,5-trimethoxyphenyl and 1-naphthalenyl analogues which showed strong suppressive activity at doses ranging from 80 to 640 mg/kg. Furthermore, several of the 2,4-pteridinediamines exhibited potent prophylactic activity against Plasmodium gallinaceum infections in the chick and also showed strong antibacterial action against Streptococcus faecalis and Staphylococcus aureus.