gebhart/patrepeval huggingface dataset:
Experimental Leukemia and Mammary Cancer: Induction, Prevention, Cure (1979)

Charles Brenton Huggins won the Nobel prize in 1966 for his extensive work in cancer research. He has spent fifty years at the laboratory bench exploring the nature of this disease in an attempt to understand and control it. In this volume, based almost exclusively on experiments conducted over the past twenty years at the University of Chicago, is both the record of Huggins's own research and, in Huggins's words, a do-it-yourself guide for cancer research workers. Written simply and clearly so that the experiments can be easily reproduced, the book presents Huggins's experiments in the induction of breast cancer and leukemia in rodents. It also describes the methods he discovered to prevent cancer and to cure many of the cancers he has been able to induce. Although most of the material concerns breast cancer and leukemia, research on other kinds of tumors is also described.
Fe-Metalloid Metallic Glasses with High Magnetic Flux Density and High Glass-Forming Ability (2007)

Fe-based bulk metallic glasses with good soft magnetic softness, high strength and relatively low material cost should have greatest potential for wide variety of applications among many kinds of bulk metallic glasses (BMGs). However, the glass-forming metal elements such as Al, Ga, Nb, Mo and so forth in the Fe-based BMGs significantly decrease saturation magnetization (Js) which is a essential property as soft magnetic materials. Since the coexistence of high Js and high glass-forming ability (GFA) has been earnestly desired from academia to industry, however, has been left unrealized over many years. Here, we present a Fe76Si9B10P5 bulk glassy alloy exhibiting with unusual combination of high Js of 1.51 T comparable to the Fe-Si-B amorphous alloy ribbons with thickness of about 25 μm in now practical use, because of not-containing the glass-forming metal elements, and high GFA leading to a rod with a diameter of 2.5 mm. This alloy composed of familiar and low-priced elements also has extremely low coercivity which should enable ultra-high efficient transformers, therefore, has a great advantage for engineering and industry, and thus significantly improves energy saving, conservation of earth resources and environment.
Three-Dimensional Distribution of Lithofacies, Bounding Surfaces, Porosity, and Permeability in a Fluvial Sandstone--Gypsy Sandstone of Northern Oklahoma (1995)

Where it was studied at two sites in north-central Oklahoma, the Gypsy sandstone of the Pennsylvanian Vamoosa Formation provides significant insights into the controls on reservoir quality in a meandering river deposit. At an outcrop site west of Tulsa, a three-dimensional architectural framework, based on erosional surfaces, allowed the recognition of a channel-fill sequence consisting of six channel sand bodies and representing at least three channel belts. Belts are vertically stacked and are incompletely separated by low-permeability flood-plain deposits, which are locally eroded. Porosity and permeability are primarily related to depositional facies. Within channel belts, mudclast lags associated with erosion surfaces at the base of channels have the potential to act as vertical permeability baffles between channel sand bodies, as do mud-draped lateral accretion surfaces within channel sand bodies. At a subsurface site 31 km (19 mi) to the west of the outcrop site, nine wells were drilled and cored through the Gypsy interval. At this site, it was possible to identify and correlate three channel belts comprising amalgamated channel sand bodies. Although lower level architectural elements could be recognized in cores, they could not be correlated with confidence given a 100-m (330-ft) well spacing.
Promoter polymorphisms in the gene encoding checkpoint kinase 1 are associated with survival in cancer (2007)

Objectives: The aim of this study was to investigate whether polymorphisms in the promoter of CHK1, which is an essential gene involved in cell cycle checkpoint control, regulate gene expression and, thereby, influence course of cancer diseases. Methods and Results: Single nucleotide polymorphisms (SNP) in the promoter region of CHK1 were identified by systematic sequencing. One of the detected SNPs, ‐1143G>T, revealed genotype‐dependent differences in functional analyses. Binding of transcription factors as shown by EMSA was significantly stronger for the G allele compared to the T allele. Furthermore, CHK1 expression in tissues of patients with GG genotype was significantly increased. Association studies were performed with different collectives of cancer patients. Overall survival of patients with bladder cancer was significantly dependent on the ‐1143G>T genotype. CHK1 ‐1143T homozygous patients displayed a higher risk for death than ‐1143G allele carriers (HR: 2.6; p=0.01). In patients with colorectal cancer, however, GG genotype was associated with a higher risk for death (HR: 3.0; p=0.03). Multivariate analysis revealed that the ‐1143G>T SNP was an independent risk factor for death. Conclusion: The identified promoter SNP in CHK1 might serve as molecular marker for survival of cancer patients. This observation may also be of interest in regard to CHK1 inhibitors which are currently investigated in phase II and III trials.
Reliable and Effective Downhole Cleaning System for Debris and Junk Removal (2006)

Abstract Wellbore debris is responsible for many of the problems and much of the extra costs associated with producing wells, especially in extreme water depths and highly deviated holes. Even a small piece of debris at the right place at the wrong time can jeopardize well production. For this reason, debris management has become a chief concern for oil and gas producers. Considering rig rates and completion equipment costs, debris removal is moving into the realm of risk management. A clean wellbore is not only a prerequisite for trouble-free well testing and completion; it also helps ensure optimum production for the life of the well. Debris left in the wellbore can ruin a complex, multi-million dollar completion; it can prevent a completion from reaching total depth. And chances are, it will never reach an optimum production level. These issues are pushing the industry to create reliable, efficient systems for quickly ridding wellbores of harmful debris and larger pieces of junk. This paper describes a vectored annular cleaning system (VACS) that can be used alone or in conjunction with any of an assortment of improved casing scrapers, brush tools, downhole magnet subs, downhole filter tools and junk catchers to optimize the efficiencies and economics of debris removal and save trips. This paper will focus on the use of the vectored annular cleaning system to collect and remove debris from areas of the wellbore that traditionally are problematic; i.e., above liner tops, where casing size changes, areas with a loss of annular velocity, and wells with little to no circulation. Case histories from the Gulf of Mexico, North Sea and other areas of the world will demonstrate how this technology has reduced problems of debris removal while saving rig time by eliminating trips.
Specific growth inhibition of primitive hematopoietic progenitor cells mediated through monoclonal antibody binding to major histocompatibility class II molecules (1992)

In a previous study using a canine model, we reported that a certain anti-class II monoclonal antibody (MoAb H81.9), which recognizes an epitope formed by the alpha and beta subunits of HLA-DR, prevented long- term engraftment of autologous marrow cells if administered intravenously during the first 4 days after 9.2 Gy of total body irradiation. Another MoAb (B1F6), reactive with only the beta subunit of HLA-DR and -DP, had no adverse effect on engraftment, although both MoAbs detect antigens on hematopoietic long-term repopulating cells as determined from complement-mediated lysis experiments. In the present study, continuous exposure of unfractionated human marrow to MoAb H81.9 specifically inhibited the growth of primitive progenitor cells that require multiple hematopoietic growth factors for proliferation (high proliferative potential colony forming cells [HPP-CFC] and burst- forming units-erythroid [BFU-e]), but had no effect on more mature, single factor responsive (CFU-GM), progenitor cells. In contrast, MoAb B1F6 did not impair primitive progenitor cell growth cultured as unfractionated marrow. However, when cell dose-response experiments were performed using CD34-positive cells plated at low cell densities, the marked inhibitory effects of MoAb H81.9 on HPP-CFC and BFU-e colony formation were not seen. These findings suggest that MoAb H81.9 may not inhibit primitive hematopoietic cells directly, but rather indirectly through the action of potent mediators derived from other HLA-DR- positive marrow cells.
Co-operation between follicular ornithine decarboxylase and v-Ha-ras induces spontaneous papillomas and malignant conversion in transgenic skin (1998)

Ornithine decarboxylase (ODC) is aberrantly regulated in tumor cells and results in high basal levels of ODC and polyamines in many epithelial tumors. To determine if elevated ODC/polyamine levels can co-operate with a mutant Ha-ras gene in mouse skin tumorigenesis, double transgenic mice were generated by breeding K6/ODC transgenic mice with TG.AC v-Ha-ras transgenic mice. A K6 keratin promoter drives the ODC transgene in K6/ ODC transgenic mice, which results in elevated ODC/ polyamine levels directed to the outer root sheath cells of hair follicles. TG.AC transgenic mice carry a v-Ha-ras transgene while still retaining two normal c-Ha-ras alleles. Transgenic mice that possess only the K6/ODC or the v-Ha-ras transgene did not develop tumors unless treated with either a carcinogen or a tumor promoter, respectively. However, a high percentage of double transgenic mice possessing both the K6/ODC and v-Ha-ras transgenes developed spontaneous tumors. All tumors were well-differentiated keratoacanthomas, some of which progressed to carcinomas within 2 months. The development and the maintenance of these ODC/ras tumors was ODC-dependent since alpha-difluoromethylornithine (DFMO), a specific ODC inhibitor, prevented the formation and caused the regression of these tumors. These findings indicate that ODC overexpression and an activated Ha-ras are sufficient to produce a high rate of malignant transformation in an animal model. The ODC/ras double transgenic mouse provides a simple in vivo model without the use of chemical carcinogens or tumor promoters in which to test downstream effectors that play a key role in mediating the development of epithelial tumors resulting from the cooperation between ODC and v-Ha-ras.
Overview of APEEM Thermal Control Research Projects (Presentation) (2007)

NREL researchers work on advancing power electronics and electric machines for many applications including advanced vehicles.
United States Attorney General (1940)

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A randomized, controlled trial of methotrexate versus placebo in early diffuse scleroderma (2001)

Although results of this trial demonstrated a trend in favor of MTX versus placebo in the treatment of early diffuse SSc, the between-group differences were small and the power to rule out false-negative results was only 50%. Our findings do not provide evidence that MTX is significantly effective in the treatment of early diffuse SSc.
Motion Planning for a Mobile Manipultor Based on Joint Motions for Error Recovery (2006)

This paper describes motion planning for a mobile manipulator which works in real environment. Mobile manipulators that can manipulate an object was developed up to now. We assume that object grasping is not restricted to just one grasp way and robot can move freely as far as it is in its operational area of the object. This paper proposes the motion planning for object grasping under the previous explained conditions. There are two major issues to detect the robot pose. The first problem is pose error of the robot hand. The second problem is kinematical redundancy of the mobile manipulator. The pose is evaluated from the amount of joint motions for recovery of hand pose error. Experiments show the effectiveness of the proposed method.
Expanding the <i>Helicobacter pylori</i> Genetic Toolbox: Modification of an Endogenous Plasmid for Use as a Transcriptional Reporter and Complementation Vector (2007)

Helicobacter pylori is an important human pathogen. However, the study of this organism is often limited by a relative shortage of genetic tools. In an effort to expand the methods available for genetic study, an endogenous H. pylori plasmid was modified for use as a transcriptional reporter and as a complementation vector. This was accomplished by addition of an Escherichia coli origin of replication, a kanamycin resistance cassette, a promoterless gfpmut3 gene, and a functional multiple cloning site to form pTM117. The promoters of amiE and pfr, two well-characterized Fur-regulated promoters, were fused to the promoterless gfpmut3, and green fluorescent protein (GFP) expression of the fusions in wild-type and delta fur strains was analyzed by flow cytometry under iron-replete and iron-depleted conditions. GFP expression was altered as expected based on current knowledge of Fur regulation of these promoters. RNase protection assays were used to determine the ability of this plasmid to serve as a complementation vector by analyzing amiE, pfr, and fur expression in wild-type and delta fur strains carrying a wild-type copy of fur on the plasmid. Proper regulation of these genes was restored in the delta fur background under high- and low-iron conditions, signifying complementation of both iron-bound and apo Fur regulation. These studies show the potential of pTM117 as a molecular tool for genetic analysis of H. pylori.
Metabolic engineering of Escherichia coli for production of mixed isoprenoid alcohols and their derivatives (2018)

The promiscuous activity of NudB was newly identified and successfully used for production of isoprenoid-based alcohol mixtures, which are suitable as next-generation biofuels or commodity chemicals. This is the first successful report on high-titer production of an isoprenoid alcohol-based mixture. The engineering approaches can provide a valuable platform for production of other isoprenoid mixtures via a proportional modulation of IPP, DMAPP, GPP, and FPP syntheses.
Cloning, expression, and sequence analysis of the Haemophilus influenzae type b strain M43p+ pilin gene (1990)

By using antiserum against Haemophilus influenzae type b (Hib) strain M43p+ denatured pilin, we screened a genomic library of Hib strain M43p+ and identified a clone that expressed pilin, but not assembled pili, on its surface. Southern blot analysis revealed the presence of one structural gene, which was also present in strain M42p-, a nonpiliated variant. Five exonuclease III deletion mutants, two of which had deletions that extended into the structural gene and failed to express pilin, were used to obtain the nucleotide sequence of the structural gene. The amino acid sequence of the open reading frame agrees with 38 of 40 amino acids from the published sequence of purified Hib M43p+ pilin. The pilin gene coded for a mature protein of 193 amino acids, with a calculated molecular mass of 21,101 daltons. Comparison of the Hib M43p+ pilin amino acid sequence with those of pilins of other bacteria revealed strong conservation of amino- and carboxy-terminal regions in M43p+ and Escherichia coli F17, type 1C, and several members of the P pili family, as well as Klebsiella pneumoniae type 3 MR/K, Bordetella pertussis serotype 2, and Serratia marcescens US46 fimbriae.
Rapid Ethanol Fermentation for Soy Sauce Production by Immobilized Yeast Cells. (1991)

Continuous ethanol fermentation was done to improve soy sauce productivity using immobilized soy sauce yeast cells. The yeast cells were immobilized physically in pores of alumina ceramic beads, and fermentation was done with a filtrate solution from soy sauce mash. The ethanol concentration was controlled by the dilution rate, and the volumetric production rate, being dependent on dilution rate, was found to be much higher than that in batch fermentation. The ethanol production system was mathematically modeled from the basic material balance and the rate equation. The simulated results agreed with the experimental ones. The reactor system with immobilized yeast cells was effective for obtaining ethanol with a high production rate.
Transfer of dendritic cells (DC)<i>ex vivo</i>stimulated with interferon-gamma (IFN-γ) down-modulates autoimmune diabetes in non-obese diabetic (NOD) mice (1999)

The NOD mouse has been used to explore the many features of insulin-dependent diabetes mellitus (IDDM) that is caused by the destruction of insulin-producing beta cells in the islets of Langerhans of the pancreas. Self-reactive T cells have been considered to mediate IDDM in the NOD mouse, and antigen-presenting cells like DC and macrophages are expected to be involved in the processes from their role in generating regulatory or effector T cells. The present study shows that transfer of IFN-gamma-stimulated DC of the NOD or ICR mouse into the NOD mouse did not accelerate IDDM onset but afforded long-lasting protection against clinical and histological signs of IDDM in the recipient mice. The anti-diabetogenic ability was unique to IFN-gamma-stimulated DC when compared with unstimulated DC. A considerable proportion of the injected IFN-gamma-stimulated DC was demonstrated to migrate into the pancreas and its associated lymphoid tissues, suggesting the DC exert their anti-diabetogenic effects there. These findings suggest that development of autoimmune diabetes in the NOD mouse is under the control of DC, and that IDDM onset could be controlled by appropriately manipulating DC systems in vivo, which may open the gate for the therapeutic application of ex vivo-conditioned DC to human IDDM.
Association of decreased intercellular communication with the immortal but not the tumorigenic phenotype in human mammary epithelial cells. (1989)

Intercellular communication was compared in early passage cultures of human mammary epithelial cells (HMEC) from normal and malignant breast tissues and immortalized nontumorigenic human breast cell lines (184A1 and 184B5). A clonogenic assay for the cell-mediated transfer of toxic metabolites of 6-thioguanine (TG) between cells was used as a measure of intercellular communication. We examined the effects of wild-type TG-sensitive (TGs) HMEC density on the survival of mutant TG-resistant (TGr) immortalized HMEC in TG-containing medium. Survival rates of TGr HMEC cocultured with TGs normal HMEC, malignant HMEC, or immortalized nontumorigenic HMEC were dependent on the density of TGs cells. For example, the percentage of recovery of TGr cells cocultured with 10(5) TGs immortalized, normal, or carcinoma HMEC was 88 +/- 4, 41 +/- 10, or 2.0 +/- 1.7, respectively. Gap junction-mediated intercellular communication between homologous HMEC types was also studied, as quantitated on the basis of Lucifer yellow dye transfer between cells in culture. Results from the dye transfer studies supported those from the metabolic cooperation studies. These results using nonimmortalized tumor cells differ from previous reports in which immortal tumor cells have been found to communicate less than their normal counterparts. Previous reports suggesting that tumor cell lines communicate less than normal cells may have resulted from the confounding influence of the immortal phenotype on the tumor phenotype.
Light transformers for kilowattt SMPS based on nanocrystalline softmagnetic cores (1998)

With high-performance IGBTs and advanced high frequency 1.2 Tesla soft magnetic alloys, switched mode power supplies (SMPS) can now be designed for the power range up to several 100 kW with a single transformer only. The weight-to-power ratio of transformers so far has reached a level of up to only 100 g/kW when using new nanocrystalline SiFe alloy VITROPERM/sup TM/ at a switching frequency of typical 10-20 kHz. The result are quite compact and lightweight SMPS with excellent efficiency.
Improving quality of care Justifying the cost for a single-patient-use blood pressure cuff (2009)

INTRODUCTION Hospital-acquired infections (HAIs), which have been a serious concern for healthcare professionals for decades, have become a topic of concern for healthcare consumers as well.1 A March 2009 study by the CDC reported that the estimated 1.7 million HAIs annually cost U.S. hospitals between $35.7 billion to $45 billion.2 This does not include the indirect costs to patients and their families. The report also evaluates the effectiveness of measures to prevent infections and estimates that as much as 70% of HAIs could be prevented, resulting in potential cost savings of $25.0 to $31.5 billion. While there are many causes of HAIs, the use of single-patient-use blood pressure cuffs can eliminate one source of contamination. While the direct cost of single-patient-use cuffs may be more than reusable cuffs, it is balanced by the savings to the hospital through the reduction in potential infections.
The low power energy aware processing (LEAP)embedded networked sensor system (2006)

A broad range of embedded networked sensor (ENS) systems for critical environmental monitoring applications now require complex, high peak power dissipating sensor devices, as well as on-demand high performance computing and high bandwidth communication. Embedded computing demands for these new platforms include support for computationally intensive image and signal processing as well as optimization and statistical computing. To meet these new requirements while maintaining critical support for low energy operation, a new multiprocessor node hardware and software architecture, Low Power Energy Aware Processing (LEAP), has been developed. The LEAP architecture integrates fine-grained energy dissipation monitoring and sophisticated power control scheduling for all subsystems including sensor subsystems. The LEAP2 platform is a second generation LEAP system with even higher resolution energy monitoring as well as the unique ability to do per process and per application energy profiling via a dedicated high performance ASIC. This poster will demonstrate the hardware platform capabilities as well as the energy-aware software currently available for LEAP2.
New Zealand in the World (1940)

New Zealand in the World Get access * New Zealand in the World. By Wood F. L. W.. 1940. (Wellington : Department of Internal Affairs. 8vo. 143 pp. 5s.) B. Y. B. Y. Search for other works by this author on: Oxford Academic Google Scholar International Affairs Review Supplement, Volume 19, Issue 2, October 1940, Pages 126–127, https://doi.org/10.2307/3025663 Published: 01 October 1940