gebhart/patrepeval huggingface dataset:
New steps for passive millimeter imaging (2007)

Passive imaging for security and other applications has reached an important level of development. Ka and W band imaging systems are now commercial products, thanks to cheap and stable amplifiers. While deployment numbers are still modest, improvements to these systems will come from engineering and algorithm development, and not fundamental research. What research should focus on are system volume reduction and resolution improvements. Fundamental research has several potential paths to solve these problems. Silicon Germanium CMOS can build acceptable millimeter wave amplifiers, and while SiGe noise figure is higher than GaAs, the ability to integrate RF and back end processing will push us closer to a CCD-like sensor. Antimony Arsenide features higher mobility than GaAs, with very low flicker noise and operation above 200 GHz which will reduce aperture size for equivalent resolution. More focus is needed in material characterization, particularly for clothing and common commercial materials. Finally, Sparse Array technology may build flat, conformal structures with high resolution and relatively low detector count. This paper will briefly discuss the time line of past innovations, and explore the advantages and challenges of the new technologies that will drive this field forward.
Internet-based system for diagnosis of coronary artery disease (2002)

An intelligent Internet-based coronary artery disease (CAD) diagnostic system based on Tl-201 planar imaging data was developed. The system can self-generate rules to correctly diagnose obstructions in the three main arteries, namely right coronary artery (RCA), left anterior descending (LAD), circumflex (CCX), or a patient being normal (with no obstructed arteries). The rule formation engine is based on the CLIP3 (Cover Learning using Integer Programming version 3) machine learning algorithm. The system stores all data (training data, fuzzy sets and rules) into a relational database. The primary consideration of the authors' design was to keep the system easy to use, thus the database operations are transparent to the user. The architecture of the system is a multithreaded structure that allows multiple operations to be carried out in parallel. The biggest advantage of the system is that a diagnosis can be carried out over the Internet via HTML forms.
AN ULTRASTRUCTURAL BASIS FOR HYPHAL TIP GROWTH IN PYTHIUM ULTIMUM (1970)

Hyphae of the fungus Pythium ultimum extend by tip growth. The use of surface markers demonstrates that cell expansion is limited to the curved portion of the hyphal apex. Growing and non‐growing regions are reflected in internal organization as detected by light and electron microscopy. The young hypha consists of three regions: an apical zone, a subapical zone and a zone of vacuolation. The apical zone is characterized by an accumulation of cytoplasmic vesicles, often to the exclusion of other organelles and ribosomes. Vesicle membranes are occasionally continuous with plasma membrane. The subapical zone is non‐vacuolate and rich in a variety of protoplasmic components. Dictyosomes are positioned adjacent to endoplasmic reticulum or nuclear envelope, and vesicles occur at the peripheries of dictyosomes. A pattern of secretory vesicle formation by dictyosomes is described which accounts for the formation of hyphal tip vesicles. Farther from the hyphal apex the subapical zone merges into the zone of vacuolation. As hyphae age vacuolation increases, lipid accumulations appear, and the proportional volume of cytoplasm is reduced accordingly. The findings are integrated into a general hypothesis to explain the genesis and participation of cell components involved directly in hyphal tip growth: Membrane material from the endoplasmic reticulum is transferred to dictyosome cisternae by blebbing; cisternal membranes are transformed from ER‐like to plasma membrane‐like during cisternal maturation; secretory vesicles released from dictyosomes migrate to the hyphal apex, fuse with the plasma membrane, and liberate their contents into the wall region. This allows a plasma membrane increase at the hyphal apex equal to the membrane surface of the incorporated vesicles as well as a contribution of the vesicle contents to surface expansion.
The authors of the method in question were asked to respond, and did so as follows: (1975)

Journal Article The authors of the method in question were asked to respond, and did so as follows: Get access Betty Lash, Betty Lash Dept. of Medicine Albert Einstein College of Medicine Yeshiva University 1300 Morris Park Ave. Bronx, N. Y. 10461 Search for other works by this author on: Oxford Academic Google Scholar Norman Fleischer Norman Fleischer Dept. of Medicine Albert Einstein College of Medicine Yeshiva University 1300 Morris Park Ave. Bronx, N. Y. 10461 Search for other works by this author on: Oxford Academic Google Scholar Clinical Chemistry, Volume 21, Issue 3, 1 March 1975, Page 449, https://doi.org/10.1093/clinchem/21.3.449 Published: 01 March 1975
Remote ultrasensitive laser microphone (2011)

This paper presents an optical fiber Mach-Zehnder interferometer configured as an ultra-sensitive sound detector. We used a 633nm, 0.5 mW, He-Ne laser, two 3dB couplers, a few meter of telecomm fiber, an U-bench mount to increase the sensitivity of the device and an acquisition system composed by a photodiode and an amplifier connected to a laptop and to an oscilloscope. The optoelectronic device enables us to record acoustic signals from sources at distances longer than 4 meters, converting the interference patterns induced by the sound waves into a digital signal. The ease of its applicability, thanks to its small size and low weight, and its ultra-sensitivity makes this laser microphone a very attractive solution to issues such as monitoring, no-detectable sensing and perimeter protection.
Deformable DETR: Deformable Transformers for End-to-End Object Detection (2020)

DETR has been recently proposed to eliminate the need for many hand-designed components in object detection while demonstrating good performance. However, it suffers from slow convergence and limited feature spatial resolution, due to the limitation of Transformer attention modules in processing image feature maps. To mitigate these issues, we proposed Deformable DETR, whose attention modules only attend to a small set of key sampling points around a reference. Deformable DETR can achieve better performance than DETR (especially on small objects) with 10 times less training epochs. Extensive experiments on the COCO benchmark demonstrate the effectiveness of our approach. Code is released at https://github.com/fundamentalvision/Deformable-DETR.
Fatigue Behavior and Microstructure of Pt-20Ir Wire as Lead Conductor in Implantable Medical Device (2012)

Pt-20Ir cold draw wire has been used as lead conductor in implantable medical devices. The lead is a medical device to transfer the electrical signal from a implanted stimulator to the body area for stimulating such as brain and neurological nerves. In this study, fatigue behavior and failure mechanism of Pt-20Ir wire was studied with rotary bending fatigue testing. The relations between the cyclic strain amplitude (ε) and the cycles to failure (N) were obtained and compared with MP35N wire which is the most commonly used metal wire as lead conductors. The results show Pt-20Ir cold drawn wire (0.102 mm) has a fatigue endurance strain limit of 0.18% which is significant lower than that of MP35N wire. Microstructure of Pt-20Ir cold draw wire was also analyzed. Results show that the grain size of in wire is elongated like bundled fiber structure. The texture of wire is strongly fiber textured and with a strong gradient from outside layer to center of the wire. Near surface region has <111> textured grain and around center region of the wire has <100> textured grain. The center of grain also has larger size than near surface.
Wavelength-Selective Switches for ROADM Applications (2010)

The trends, architecture, and performance of wavelength-selective switches (WSS) are analyzed in the context of their application to reconfigurable optical add/drop multiplexer (ROADM)-based optical networks. The resulting analyses define the requirements for the latest generation of ROADM systems and provide insight into the critical specifications of this technology. In addition, the current trends for WSS technology are reviewed in the context of synergies with the strengths of different switching technologies.
Linear Relaxations for Transmission System Planning (2011)

We apply a linear relaxation procedure for polynomial optimization problems to transmission system planning. The approach recovers and improves upon existing linear models based on the DC approximation. We then consider the full AC problem, and obtain new linear models with nearly the same efficiency as the linear DC models. The new models are applied to standard test systems, and produce high-quality approximate solutions in reasonable computation time.
Bias of an optical passive ring-resonator gyro caused by the misalignment of the polarization axis in the polarization-maintaining fiber resonator (1992)

An analysis is presented of the bias of an optical passive ring-resonator gyro caused by the misalignment of the polarization axis in the resonator formed by the polarization-maintaining fiber. A large bias takes place when the phase difference between the two polarization modes of the fiber is equal to the amount of 2 pi times an integer. It is clarified that the bias can be suppressed by setting the fiber polarizers at the lead portions of the resonator, which was a method proposed originally to reduce the bias in an ideal resonator without the misalignment.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Isolation of Human Corneal Endothelial Cell Precursors and Construction of Cell Sheets by Precursors (2006)

The sphere-forming assay may become a powerful tool for the regeneration of human CE by precursor injection and the construction of cultured CE sheets.
Synthesis of “click” alginate hydrogel capsules and comparison of their stability, water swelling, and diffusion properties with that of Ca<sup>+2</sup> crosslinked alginate capsules (2014)

Ionically crosslinked alginate hydrogels have been extensively explored for encapsulation and immunoisolation of living cells/tissues to develop implantable cell therapies, such as islet encapsulation for bioartificial pancreas. Chemical instability of these hydrogels during long-term implantation hinders the development of viable cell therapy. The exchange between divalent crosslinking ions (e.g., Ca(+2) ) with monovalent ions from physiological environment causes alginate hydrogels to degrade, resulting in exposure of the donor tissue to the host's immune system and graft failure. The goal of this study was to improve stability of alginate hydrogels by utilizing covalent "click" crosslinking while preserving other biomedically viable hydrogel properties. Alginate was first functionalized to contain either pendant alkyne or azide functionalities, and subsequently reacted via "click" chemistry to form "click" gel capsules. Alginate functionalization was confirmed by NMR and gel permeation chromatography. When compared with Ca(+2) capsules, "click" capsules exhibited superior stability in ionic media, while showing higher permeability to small size diffusants and similar molecular weight cut-off and water swelling. Physicochemical properties of "click" alginate hydrogels demonstrate their potential utility for therapeutic cell encapsulation and other biomedical applications.
Structure of the mouse 5-HT 1c 5-HT 2 and stomach fundus serotonin receptor genes (1992)

By analysis of the mouse 5-HT1C receptor gene we found that its coding region contains three introns. We next isolated cDNA and genomic clones for the closely related 5-HT2 receptor using a probe derived from the 5-HT1C receptor sequence. This probe also hybridized to an additional gene, called SRL (Serotonin Receptor Like). We have evidence demonstrating that it encodes the stomach fundus 5-HT receptor. Two introns are present within the coding regions of the mouse 5-HT2 receptor gene and the SRL gene at positions which correspond to those of introns in the 5-HT1C receptor gene. This intron distribution is unique and distinguishes these receptors from other members of the family of receptors coupled to G-proteins.
Do Human Tears Absorb Ultraviolet Light? (1994)

We analyzed human tears by ultraviolet (UV) spectrophotometry for transmittance of UV light. Ultraviolet light was readily transmitted through human tears in the UV-A (320-400 nm) and UV-B (290-320 nm) ranges. Tears partially absorbed UV light in the UV-C (100-290 nm) range. The clinical implications of these findings include prevention of phototoxic ocular damage and effects upon excimer laser corneal photoablative techniques.
The Possible Potential Therapeutic Targets for Drug Induced Gingival Overgrowth (2013)

Gingival overgrowth is a side effect of certain medications. The most fibrotic drug-induced lesions develop in response to therapy with phenytoin, the least fibrotic lesions are caused by cyclosporin A, and the intermediate fibrosis occurs in nifedipine-induced gingival overgrowth. Fibrosis is one of the largest groups of diseases for which there is no therapy but is believed to occur because of a persistent tissue repair program. During connective tissue repair, activated gingival fibroblasts synthesize and remodel newly created extracellular matrix. Proteins such as transforming growth factor (TGF), endothelin-1 (ET-1), angiotensin II (Ang II), connective tissue growth factor (CCN2/CTGF), insulin-like growth factor (IGF), and platelet-derived growth factor (PDGF) appear to act in a network that contributes to the development of gingival fibrosis. Since inflammation is the prerequisite for gingival overgrowth, mast cells and its protease enzymes also play a vital role in the pathogenesis of gingival fibrosis. Drugs targeting these proteins are currently under consideration as antifibrotic treatments. This review summarizes recent observations concerning the contribution of TGF-β, CTGF, IGF, PDGF, ET-1, Ang II, and mast cell chymase and tryptase enzymes to fibroblast activation in gingival fibrosis and the potential utility of agents blocking these proteins in affecting the outcome of drug-induced gingival overgrowth.
Organisation of the entire rabbit progesterone receptor mRNA and of the promoter and 5′ flanking region of the gene (1988)

cDNA clones corresponding to the 3' and 5' non coding regions of the rabbit progesterone receptor (rPR) mRNA and genomic clones corresponding to the promoter and 5' flanking region of this gene were isolated and sequenced up to nucleotide -2761. The 3' non coding region is very long (3058-3553 nucleotides) and contains three different polyadenylation sites. Primer extension experiments and S1 mapping showed the existence of 2 transcription initiation sites 699 and 712 bp upstream from the initiator ATG. The promoter region contains two modified TATA boxes: TAGAAA at -17 and TAGA at -37bp. A CAACT sequence is present at position -100 and one consensus binding site for the transcription factor Sp1 is found at position -51. A 317 bp sequence was observed (positions -2590 to -2273) which belongs to the C family of the short interspersed repeats of the rabbit. Sequences resembling the consensus for estrogen and progesterone responsive elements are observed at several locations in the 5' flanking region. The progesterone receptor is present in tissue extracts mainly as a mixture of two molecular species (110 and 79 kDa) whose origin remains currently debated. By Northern blot analysis we have shown, using rabbit and human mRNAs, that these receptor species are not derived from separate mRNAs. Transcription-translation experiments also showed that, at least in vitro, they are not derived by use of different translation initiation sites on the same messenger RNA.
Viral Drug Sensitivity Testing Using Quantitative PCR: Table 1 (2010)

Our objective was to determine whether quantitative polymerase chain reaction (PCR) can be used to measure the effect of tyrosine kinase (TK) inhibition on polyomavirus BK (BKV) replication. The BKV was grown in a cell culture system. The rate of viral replication in the presence or absence of the drug being tested was assessed by amplifying the viral genome using primers directed against the viral capsid 1 protein. Dasatinib, erlotinib, gefitinib, imatinib, sunitinib, and sorafenib all showed antiviral activity at micromolar concentrations. The 50% effective concentration for erlotinib and sorafenib was within blood concentrations readily achieved in human subjects. Quantitative PCR is a convenient method for viral drug sensitivity testing for slow-growing viruses that do not readily produce cytopathic effect. TK inhibitors deserve further consideration as a potential therapeutic option for BKV-associated nephropathy and hemorrhagic cystitis.
Prevention of Rethrombosis After Coronary Thrombolysis in a Chronic Canine Model. II. Adjunctive Therapy with r-Hirudin (1994)

Summary We examined the effectiveness of the direct-acting thrombin inhibitor, recombinant hirudin (r-hirudin), for prevention of coronary rethrombosis after thrombolysis with recombinant tissue plasminogen activator (rt-PA) in a canine model of coronary artery thrombosis. The reocclusion rate of 15–30% associated with thrombolytic therapy emphasizes the need for adjuctive therapy to prevent rethrombosis. We studied r-hirudin for its potential to prevent reocclusion in a model of coronary artery thrombosis/thrombolysis. The circumflex coronary arteries of anesthetized dogs were instrumented with a flow probe, an intraluminal electrode, and a ligature stenosis. The dogs were reanesthetized on the ninth postoperative day, and intimal injury was induced with an anodal current. After occlusive thrombus formation, tissue plasminogen activator (rt-PA) was administered. The animals were allocated to receive either placebo, r-hirudin [5 mg/kg intravenously (i.v.) bolus, 2 mg/kg/h i.v., for 3.5 h] or r-hirudin (5 mg/kg i.v., bolus, 1 mg/kg/h i.v., for 12 h). Neither aspirin nor heparin was used. Ex vivo platelet function and coronary artery blood flow velocity were recorded on each of 5 consecutive days. Infarct size and residual thrombus weight were determined at the end of the protocol. r-Hirudin infusion (3.5 and 12 h) provided little benefit over rt-PA alone. Ex vivo platelet aggregation was not affected by r-hirudin. Little improvement in the incidence of reocclusion and mortality in a model of coronary artery thrombosis/thrombolysis resulted from adjunctive treatment with r-hirudin
Prosthetic outcome of cement‐retained implant‐supported fixed dental restorations: a systematic review (2011)

The aim of the article is to assess the current literature in terms of the prosthetic outcome of cement-retained implant-supported fixed restorations, as well as to determine the type of cement that can be recommended for clinical application. A review of the literature published up to May 2010 was conducted to identify clinical studies about cement-retained implant-supported fixed restorations. The search strategy applied was a combination of MeSH terms and free text words, including the following keywords: implants, implant-supported fixed dental prostheses (FDPs), bridges, implant-supported single crowns (SCs), cement-retained, cement fixation, cement, cementation, cement failure, retention, and loss of retention, technical complications, mechanical complications, prosthetic complication, retrievability and maintenance. Thirty-two studies met the inclusion criteria. The studies were divided into two categories: 15 short-term clinical studies with an observation period of less than 5 years, and 17 long-term clinical studies with an observation period of 5 years and more. The most common technical complications of cement-retained implant-supported fixed restorations were loss of retention, chipping and abutment screw loosening. The results of the current review revealed no guidelines about cement or cementation procedures. It may be stated that despite the questionable retrievability of cement-retained implant-supported fixed restorations, this treatment modality is a reliable and effective option, especially for implant-supported SCs and short-span FDPs. The literature does not provide accurate information about the clinical outcome of cement-retained implant-supported fixed restorations nor about the ideal type of cement that facilitates stability and maintains retrievability. Standardised randomised clinical trials will provide valuable information to this issue.
Recognition of lettuce downy mildew effector BLR38 in <i>Lactuca serriola</i> LS102 requires two unlinked loci (2018)

Plant-pathogenic oomycetes secrete effector proteins to suppress host immune responses. Resistance proteins may recognize effectors and activate immunity, which is often associated with a hypersensitive response (HR). Transient expression of effectors in plant germplasm and screening for HR has proven to be a powerful tool in the identification of new resistance genes. In this study, 14 effectors from the lettuce downy mildew Bremia lactucae race Bl:24 were screened for HR induction in over 150 lettuce accessions. Three effectors-BLN06, BLR38 and BLR40-were recognized in specific lettuce lines. The recognition of effector BLR38 in Lactuca serriola LS102 did not co-segregate with resistance against race Bl:24, but was linked to resistance against multiple other B. lactucae races. Two unlinked loci are both required for effector recognition and are located near known major resistance clusters. Gene dosage affects the intensity of the BLR38-triggered HR, but is of minor importance for disease resistance.
Inhibition of carrier‐mediated uptake of epirubicin reduces cytotoxicity in primary culture of rat hepatocytes (2007)

Epirubicin, an antineoplastic drug, is considered to be taken up by tumor cells via a common carrier by facilitated diffusion and is then pumped out in an energy-dependent manner because epirubicin is a substrate for P-glycoprotein (P-gp). However, this study investigated the details of the influx mechanism of epirubicin and demonstrated that epirubicin uptake was mediated by active carrier systems in addition to facilitated diffusion in the primary culture of rat hepatocytes. The uptake of epirubicin gradually increased in a saturated manner when the concentrations were between 1 x 10(-7) M and 1 x 10(-6) M. In contrast, the uptake increased progressively in a linear manner when the concentration was high (greater than 1 x 10(-6) M). The uptake of epirubicin at a clinical concentration (7.5 x 10(-7) M) was significantly reduced at 4 degrees C and significantly inhibited when pretreated with metabolic inhibitors (carbonyl cyanide p-trifluoromethoxyphenylhydrazone (FCCP), rotenone and sodium azide) by nearly 25%. Furthermore, an organic anion transporter inhibitor, namely, 4,4'-diisothiocyanato-stilbene-2,2'-disulfonic acid (DIDS); organic anion transport substrates, namely, para-aminohippurate (PAH), taurocholic acid and estradiol 17-beta-D-glucuronide; and organic cation transporter inhibitors, namely, verapamil and tetraethylammonium significantly reduced the uptake of epirubicin. Furthermore, pretreatment with verapamil and PAH significantly prevented epirubicin-induced reduction of proliferative activity in rat hepatocytes. These results indicated that the uptake of epirubicin was induced, at least in part, by the active transport protein in rat hepatocytes; the inhibition of the probable transport protein protected the intact normal cells from the injury induced by the cytotoxicity of epirubicin.