gebhart/patrepeval huggingface dataset:
Axillary Hyperhidrosis: A 5-Year Review of Treatment Efficacy and Recurrence Rates Using a New Arthroscopic Shaver Technique (2007)

The authors' new arthroscopic shaver technique is efficacious, with no significant morbidity, a 96 percent satisfaction rate, a subjectively measured 75 percent reduction of sweat, and a recurrence rate of only 6 percent. For cases of primary hyperhidrosis affecting the axilla not amenable to conservative treatment, the authors recommend an arthroscopic shaver technique as the first-line treatment of choice.
Recent Advances in the Catalytic Synthesis of 2,5-Furandicarboxylic Acid and Its Derivatives (2015)

Catalytic synthesis of value-added chemicals from renewable biomass or biomass-derived platform chemicals is an important way to reduce current dependence on fossil-fuel resources. In recent years, 2,5-furandicarboxylic acid (FDCA) has received significant attention due to its wide application in many fields, particularly as a substitute of petrochemical-derived terephthalic acid in the synthesis of useful polymers. Therefore, much effort has been devoted to the catalytic synthesis of FDCA. In this critical review, we will provide an overview of concise and up-to-date methods for the synthesis of FDCA from HMF oxidation or directly from carbohydrates by one-pot reaction, giving special attention to catalytic systems, mechanistic insight, reaction pathway, and catalyst stability. In addition, the one-pot oxidative conversion of carbohydrates into FDCA and the one-pot synthesis of FDCA derivatives are also discussed. It is anticipated that the chemistry detailed in this review will guide researchers to develop effective catalysts for the economical and environmentally friendly synthesis of FDCA in large-scale.
Nickel Compounds as Catalyst Raw Materials (1952)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNickel Compounds as Catalyst Raw MaterialsJohn G. DeanCite this: Ind. Eng. Chem. 1952, 44, 5, 985–990Publication Date (Print):May 1, 1952Publication History Published online1 May 2002Published inissue 1 May 1952https://pubs.acs.org/doi/10.1021/ie50509a024https://doi.org/10.1021/ie50509a024research-articleACS PublicationsRequest reuse permissionsArticle Views185Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Nutritional and environmental factors affecting growth and antifungal activity of a sterile red fungus against <i>Gaeumannomyces graminis</i> var. <i>tritici</i> (1994)

Growth and antifungal activity of a sterile red fungus against Gaeumannomyces graminis var. tritici (the take-all fungus) in vitro was greatly influenced by nutritional and environmental conditions. The utilization by the sterile red fungus of various carbon and nitrogen sources differed considerably at pH 5.5 and 6.5. Maximum growth of the sterile red fungus occurred when pectin was supplied as the carbon source at both pH levels. As nitrogen sources, NH 4 H 2 PO 4 supported maximum growth at pH 5.5, whereas Ca(NO 3 ) 2 was the best at pH 6.5. Pectin strongly enhanced the antifungal activity of the sterile red fungus towards the take-all fungus as did Ca(NO 3 ) 2 supplied as a N source. There was, however, little or no antagonism in the presence of calcium citrate, arabinose, leucine, or arginine. In general, antagonism was optimal at 20 °C and at pH 5.5. Key words: sterile red fungus, Gaeumannomyces graminis var. tritici, biological control.
Design and evaluation of statistical control procedures: applications of a computer "quality control simulator" program. (1981)

A computer simulation program has been developed to aid in designing and evaluating statistical control procedures. This "QC stimulator" (quality control) program permits the user to study the effects of different factors on the performance of quality-control procedures. These factors may be properties of the analytical procedure, characteristics of the instrument system, or conditions for the quality-control procedure. The performance of a control procedure is characterized by its probability for rejection, as estimated at several different magnitudes of random and systematic error. These performance characteristics are presented graphically by power functions-plots of the probability for rejection vs the size of the analytical errors. The utility of this stimulation tool is illustrated by application to multi-rule single-value procedures, mean and range procedures, and a trend analysis procedure. Careful choice of control rules is necessary to minimize false rejections and to optimize error detection with multi-rule procedures. Control limits must be carefully calculated for optimum performance of mean and range procedures. The level of significance for testing control must be carefully selected for the trend analysis procedure.
Expression of the 27-kDa heat shock protein in human epidermis and in epidermal neoplasms: an immunohistological study (1995)

The 27-kDa heat shock protein (HSP27) is a member of the small heat shock protein (HSP) family. In addition to its putative function in thermotolerance, this protein may play a part in the regulation of cell growth and differentiation. This study was conducted to assess the significance of the expression of HSP27 in human epidermis and in cutaneous neoplasms. Sixty-two biopsy samples from normal human skin and from inflammatory and neoplastic skin diseases were investigated by immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, using a monoclonal antibody specific for HSP27. In normal human epidermis, HSP27 is expressed in the upper epidermal layers with a cytoplasmic staining pattern. The basal cell layer does not express detectable amounts of HSP27. In hair follicles, staining is mainly confined to the outer root sheath and to the infundibular epithelium. Melanocytes, dermal fibroblasts and endothelial cells do not express detectable amounts of HSP27. HSP27 could not be detected in fetal skin until the 20th week of gestation. Tumour cells in basal and squamous cell carcinomas do not express significant amounts of HSP27. In solar keratoses, seborrhoeic keratoses, human papillomavirus (HPV)-induced hyperproliferative lesions and inflammatory skin conditions, HSP27 expression largely resembles the pattern observed in normal human skin. HSP27 is expressed in a differentiation-related pattern in normal human epidermis and hyperproliferative disorders of the epidermis. We conclude that HSP27 may be regarded as a marker of differentiation in epidermal keratinocytes. Absence of HSP27 in the upper epidermal layers may be a marker for epidermal malignancy.
Identification of the antimetabolite of L-alanosine, L-alanosyl-5-amino-4-imidazolecarboxylic acid ribonucleotide, in tumors and assessment of its inhibition of adenylosuccinate synthetase. (1980)

The conjugate of L-alanosine [L-2-amino-3-(N-hydroxyN-nitrosamino)propionic acid] and 5-amino-4-imidazolecarboxylic acid ribonucleotide has been synthesized in good yield by enzymatic means, using partially purified chicken liver 5-amino-4-imidazole-N-succinocarboxamide ribonucleotide synthetase (EC 6.3.2.6). The chromatographic behavior of this molecule was characterized, as was its ability to inhibit adenylosuccinate synthetase, an enzyme long considered to be the locus of action of the drug. The Ki of-L-alanosyl-5-amino-4-imidazolecarboxylic acid ribonucleotide versus a partially purified adenylosuccinate synthetase frm the L5178y/AR leukemia of C57BL X DBA/2 F1 (hereafter called BD2F1) mice was 0.228 microM, whereas the Ki of L-alanosine was 57.23 mM. Administration of 50 microCi of DL-[1-14C]alanosine along with unlabeled L-alanosine (500 mg/kg) to BD2F1 mice bearing s.c. nodules of Leukemia L5178Y/AR resulted in the accumulation in tumors of a material with properties compatible with those of L-alanosyl-5-amino-4-imidazolecarboxylic acid ribonucleotide. It coeluted with L-alanosyl-5-amino-r-imidazolecarboxylic acid ribonucleotide in the high-resolution chromatographic system used, was Bratton-Marshall positive, and inhibited adenylosuccinate synthetase strongly. In tumor nodules 2 hr after dosage, the concentration of this compound approximated 70 microM. Under the same circumstances, the intratumoral concentration of L-alanosine was found to be 440 microM. At this concentration, the antibiotic itself exerts only a marginal inhibition of leukemic adenylosuccinate synthetase. In ancillary studies, it was shown for the first time in vivo that the parenteral administration of L-alanosine reduces the specific activity of intratumoral adenylosuccinate synthetase by 70% and depresses the synthesis of DNA to an equivalent or greater extent; adenine but not hypoxanthine (both at 250 mg/kg) was able to reverse the latter inhibition. No effect on purine salvage enzymes was exerted by L-alanosine. Viewed in concert, these experiments establish that the adduct of L-alanosine with 5-amino-4-imidazolecarboxylic acid is formed by neoplastic cells in vivo and that this anabolite is most probably responsible for the inhibition of adneylosuccinate synthetase and, in turn, for the diminished synthesis of DNA seen after a therapeutic dose of L-alanosine.
Antagonist principle: John Henry Newman and the paradox of personality (2015)

The Antagonist Principle is a critical examination of the works and sometimes controversial public career of John Henry Newman (1801-1890), first as an Anglican and then as Victorian England's most famous convert to Roman Catholicism at a time when such a conversion was not only a minority choice but in some quarters a deeply offensive one. Lawrence Poston adopts the idea of personality as his theme, not only in the modern sense of warring elements in one's own temperament and relationships with others but also in a theological sense as a central premise of orthodox Trinitarian Christian doctrine. The principle of antagonism, in the sense of opposition, Poston argues, activated Newman's imagination while simultaneously setting limits to his achievement, both as a spiritual leader and as a writer. The author draws on a wide variety of biographical, historical, literary, and theological scholarship to provide an ethical reading of Newman's texts that seeks to offer a humane and complex portrait. Neither a biography nor a revelation of a life, this textual study of Newman's development as a theologian in his published works and private correspondence attempts to resituate him as one of the most combative of the Victorian seekers. Though his spiritual quest took place on the far right of the religious spectrum in Victorian England, it nonetheless allied him with a number of other prominent figures of his generation as distinct from each other as Thomas Carlyle, John Stuart Mill, and Walter Pater. Avoiding both hagiography and iconoclasm, Poston aims to see Newman whole.
An inhibition enzyme immunoassay using a human monoclonal antibody (K14) reactive with gp41 of HIV-1 for the serology of HIV-1 infections (1991)

An inhibition enzyme immunoassay (IEIA), using a human monoclonal antibody (K14) reactive with gp41 of HIV-1, was evaluated for its applicability to the serology of HIV-1 infections. Using panels of serum samples from seronegative and confirmed HIV-1-seropositive individuals, it was shown that all the HIV-1-positive samples in a panel from The Netherlands and 97% of the HIV-1-positive samples from Tanzania were identified by this IEIA. Six per cent of the IEIA-positive samples from Tanzania could not be confirmed in other assays. Testing of serial dilutions of serum samples from African individuals with confirmed HIV-1, HIV-2 or HIV(ANI70) infections in the K14 IEIA, indicated that a HIV-1-specific assay based on this principle may be developed.
Lipid-soluble diaminopyrimidine inhibitors of dihydrofolate reductase. (1977)

On the basis of activity against experimental tumors and potency as inhibitors of human dihydrofolate reductase, two compounds were selected for pharmacokinetic evaluation: metoprine ((2,4-diamino-5-(3',4'-dichlorophenyl)-6-methyl pyrimidine, DDMP, B.W. 197U) and etoprine, the corresponding 6-ethyl analog (DDEP, B.W. 276U). These lipid-soluble compounds readily cross the blood-brain barrier and penetrate rapidly into brain and brain tumors induced in rats by ethylnitrosourea. Both compounds are extensively bound to human plasma protein and their slow elimination from plasma and tissues contrasts with the kinetics of methotrexate. Cerebrospinal fluid levels of "folate" were elevated following oral administration of citrovorum factor to rats but not following equivalent doses of folic acid. The balance between selective action of the drug and selective protection by the vitamin is discussed with regard to differential distribution into separate compartments.
Role of intestinal inflammation as an early event in obesity and insulin resistance (2011)

The role of diet-induced intestinal inflammation as an early biomarker and mediator of obesity, and insulin resistance warrants further study.
Dose Equivalent Response of Personal Neutron Dosemeters as a Function of Angle (1997)

The measured and calculated dose equivalent response as a function of angle has been examined for an albedo-type thermoluminescence dosemeter (TLD) that was exposed to unmoderated and D<sub>2</sub>O-moderated <sup>252</sup>Cf neutron sources while mounted on a 40 x 40 x 15 cm<sup>3</sup> polymethylmethacrylate phantom. The dosemeter used in this study is similar to many neutron personal dosemeters currently in use. The detailed construction of the dosemeter was modelled, and the dose equivalent response was calculated, using the MCNP code. Good agreement was found between the measured and calculated values of the relative dose equivalent angular response for the TLD albedo dosemeter. The relative dose equivalent angular response was also compared with the values of directional and personal dose equivalent as a function of angle published by Siebert and Schuhmacher.
Experimental field study of problem‐solving using tools in free‐ranging capuchins (<i>Sapajus nigritus</i>, formerly<i>Cebus nigritus</i>) (2011)

Some populations of capuchins are reported to use tools to solve foraging problems in the wild. In most cases, this involves the act of pounding and digging. The use of probing tools by wild capuchins is considerably less common. Here we report on the results of an experimental field study conducted in southern Brazil designed to examine the ability of wild black-horned capuchins (Sapajus nigritus) to use a wooden dowel as a lever or a probe to obtain an embedded food reward. A group of eight capuchins was presented with two experimental platforms, each housing a clear Plexiglas box containing two bananas on a shelf and four inserted dowels. Depending on the conditions of the experiment, the capuchins were required either to pull (Condition I) or push (Conditions II and III) the dowels, in order to dislodge the food reward from the shelf so that it could be manually retrieved. In Condition I, four individuals spontaneously solved the foraging problem by pulling the dowels in 25% (72/291) of visits. In Conditions II and III, however, no capuchin successfully pushed the dowels forward to obtain the food reward. During these latter two experimental conditions, the capuchins continued to pull the dowels (41/151 or 27% of visits), even though this behavior did not result in foraging success. The results of these field experiments are consistent with an identical study conducted on wild Cebus capucinus in Costa Rica, and suggest that when using an external object as a probe to solve a foraging problem, individual capuchins were able to rapidly learn an association between the tool and the food reward, but failed to understand exactly how the tool functioned in accomplishing the task. The results also suggest that once a capuchin learned to solve this tool-mediated foraging problem, the individual persisted in using the same solution even in the face of repeated failure (slow rate of learning extinction).
Wine by-Products: Phenolic Characterization and Antioxidant Activity Evaluation of Grapes and Grape Pomaces from Six Different French Grape Varieties (2014)

Grenache, Syrah, Carignan Noir, Mourvèdre, Counoise and Alicante Bouchet grape seeds and skins, harvested in 2009 and 2010 in the Rhône valley area of France, and their respective pomaces remaining after vinification, were analyzed for their phenolic composition and antioxidant activity. The polyphenol content was quantified by HPLC and the Folin-Ciocalteu assay. The antioxidant potential was measured with four different assays: ORAC, FRAP, ABTS and DPPH. Seeds contained higher amounts of total polyphenols, up to 44.5 mg of gallic acid equivalent [GAE]/g dry weight in Alicante pomace, than skin extracts. The maximum total phenolic in skins was 31.6 mg GAE/g dry weight detected in 2010 Alicante pomace. Seeds also had the highest antioxidant capacity. HPLC analysis revealed that, despite the vinification process, pomaces still contained an appreciable amount of proanthocyanidins as well as several anthocyanin glycosides. Alicante and Syrah proved to be the varieties of most interest in terms of their potential development for nutraceutical purposes.
Cross-reactivities between human IgMs and the four serotypes of dengue virus as probed with artificial homodimers of domain-III from the envelope proteins (2013)

The results should help better understand the IgM immune response and protection against DENV since ED3 is widely used as an antigen in diagnostic assays and an immunogen in vaccine candidates.
X-ray characterisation of normal and neoplastic breast tissues (1987)

Normal and neoplastic breast tissues have been characterised in terms of x-ray attenuation. Samples of normal fat and fibrous tissue were obtained from reduction mammoplasty and autopsy, and infiltrating duct carcinoma specimens from mastectomy and lumpectomy. A high-purity germanium spectroscopy system and a beam of 120 kV constant potential x-rays were used to determine the linear attenuation coefficient from 18 to 110 keV. Densities were determined from buoyancy measurements and were used to obtain mass attenuation coefficients. Infiltrating duct carcinomas and fat are well distinguished by x-ray attenuation. For photon energies used for film-screen mammography, infiltrating duct carcinomas are more attenuating than fibrous tissue. Above 31 keV, the ranges of attenuation of the two tissue types overlap. The attenuation coefficients of tissues have been concisely represented by equivalent thicknesses of lucite and aluminium. Analysis based on the average attenuation properties of tissues indicates that dual-energy mammography, using an ideal imaging system, would require 0.06 cGy to provide images in which 1 cm infiltrating duct carcinomas are displayed with a signal to noise ratio of 5 against a background over which the fat/fibrous contrast has been suppressed. This dose is similar to that currently used in conventional film-screen mammography.
The coupled mode parabolic equation (1997)

The coupled mode parabolic equation (PE) is a generalization of the adiabatic mode PE that includes mode coupling terms. It is practical to apply this approach to large-scale problems involving coupling of energy between both modes and azimuths. The solution is expressed in terms of the normal modes and mode coefficients, which satisfy coupled horizontal wave equations. The coupled mode PE may be solved efficiently with the splitting method. The first step is equivalent to solving the adiabatic mode PE over one range step. The second step involves the integration of the coupling term. The coupling mode PE solution conserves energy, which is an important aspect of a range-dependent propagation model. The derivation of the coupled mode PE, which involves completing the square of an operator, is related to the derivation of an adiabatic mode PE that accounts for ambient flow. Examples are presented to illustrate the accuracy of the coupled mode PE.
SWELLING KINETICS OF SMALL SPHERICAL IONIC GELS (1987)

ABSTRACT The kinetics of swelling of small spheres of polyacrylic acid gels has been investigated both in pure and salted water. The results suggest that the swelling process is diffusive.The effect of polydispersity of particle size is discussed.
p-Nitro p-Acylphenyl Sulfides and Related Compounds (1956)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTp-Nitro p-Acylphenyl Sulfides and Related CompoundsH. Harry Szmant and Donald A. IrwinCite this: J. Am. Chem. Soc. 1956, 78, 17, 4386–4389Publication Date (Print):September 1, 1956Publication History Published online1 May 2002Published inissue 1 September 1956https://pubs.acs.org/doi/10.1021/ja01598a053https://doi.org/10.1021/ja01598a053research-articleACS PublicationsRequest reuse permissionsArticle Views48Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Robust Object Tracking with Online Multiple Instance Learning (2010)

In this paper, we address the problem of tracking an object in a video given its location in the first frame and no other information. Recently, a class of tracking techniques called "tracking by detection" has been shown to give promising results at real-time speeds. These methods train a discriminative classifier in an online manner to separate the object from the background. This classifier bootstraps itself by using the current tracker state to extract positive and negative examples from the current frame. Slight inaccuracies in the tracker can therefore lead to incorrectly labeled training examples, which degrade the classifier and can cause drift. In this paper, we show that using Multiple Instance Learning (MIL) instead of traditional supervised learning avoids these problems and can therefore lead to a more robust tracker with fewer parameter tweaks. We propose a novel online MIL algorithm for object tracking that achieves superior results with real-time performance. We present thorough experimental results (both qualitative and quantitative) on a number of challenging video clips.