gebhart/patrepeval huggingface dataset:
Angular momentum desaturation for Skylab using gravity gradient torques (1971)

An angular momentum desaturation method for momentum exchange devices of orbiting spacecraft is described. The specific application of the method is to the Skylab which contains three double-gimbaled control moment gyros for precise attitude control and maneuvering. It is assumed that the attitude reference is inertially fixed and that two of the vehicle principal moments of inertia are much larger than the third. Gravity gradient torques and resultant angular momentum accumulation are developed for small deviations from the reference. The assumed moment-of-inertia distribution allows desaturation about all axes with only two attitude angles each for the two axes with large moments of inertia. The necessary desaturation maneuvers can be decoupled for a special set of orbital coordinates. All maneuvers are made during the night portion of the orbit, and the percentage utilized for desaturation is selectable. Expressions for the attitude angle commands are developed assuming infinite vehicle rates. The effect of finite rates introduces an efficiency into the desaturation. Expressions for this efficiency are developed and means for compensation are treated. Arbitrary misalignments between geometric vehicle axes and principal moment-of-inertia axes are permissible. An angle bias about the sun line minimizes the angular momentum accumulation about the sun line projection into the orbital plane. Adaptive desaturation maneuver limiting consistent with the available maneuver momentum is included.
The Practice of Law: Justice or Just a Job? (2004)

The practice of law is rewarding and plays an immensely important role in achieving real justice. But at times upholding law is to betray justice. If justice is lawyer's vocation, it has to be upheld when it is most threatened.
Privacy disclosure risk: smartphone user guide (2013)

A sharp increase in mobile device and applications raise serious concern on individual privacy risk in smartphone. Capabilities of current mobile device which enable it to have similar functionality with notebook inspires user to use it for many purposes. However, the scenario attracts attacker to intrude privacy in order to gain data on the device for specific purpose. This paper presents a preliminary study on privacy risks in smartphone environment from individual user perspective. The contribution of this paper is two fold. First, the privacy risks are reviewed from physical and logical viewpoint. Then an online survey is conducted to gain initial perception of privacy practice among users. Second contribution is by providing and discussing a guideline to deal with privacy risk incident on smartphone. As conclusion, future work and research on privacy risk is discussed to generate more contributions in this area.
Water Deficit as a Driver of the Mutualistic Relationship between the Fungus <i>Trichoderma harzianum</i> and Two Wheat Genotypes (2008)

The aim of this study was to assess the occurrence of mutualistic interactions between the fungus Trichoderma harzianum and two wheat genotypes, Triticum aestivum cv. Talhuén and T. turgidum subsp. durum cv. Alifén, and the extent to which water deficit affected these interactions. Two wheat genotypes were cultivated in the presence or absence of T. harzianum and in the presence or absence of water deficit. T. harzianum was in turn cultivated in the presence or absence of wheat plants and in the presence or absence of water deficit. To evaluate the plant-fungus interactions, the root volume, dry biomass, and fecundity of wheat were determined, as was the population growth rate of the fungus. Trichoderma harzianum exerted a positive effect only on plants subjected to water deficit. The population growth rate of T. harzianum was negative in the absence of wheat plants and reached its highest level in the presence of plants under conditions of water deficit. These results confirm the occurrence of a mutualistic interaction between wheat and T. harzianum and show that it is asymmetric and context dependent.
Albedo, atmospheric solar absorption and heating rate measurements with stacked UAVs (2007)

Abstract This paper reports unique measurements of albedo, atmospheric solar absorption, and heating rates in the visible (0.4 to 0.7 µm) and broadband (0.3 to 2.8 µm) spectral regions using vertically stacked multiple lightweight autonomous unmanned aerial vehicles (UAVs). The most significant finding of this study is that when absorbing aerosols and water vapour concentrations are measured accurately and accounted for in models, and when heating rates are measured directly with stacked aircraft, the simulated clear sky heating rates are consistent with the observed broadband heating rates within experimental errors (about 15%). We conclude that there is no need to invoke anomalous or excess absorption or unknown physics in clear skies. Aerosol–radiation–cloud measurements were made over the tropical Indian Ocean within the lowest 3 km of the atmosphere during the Maldives Autonomous UAV Campaign (MAC). The UAVs and ground‐based remote sensing instruments determined most of the parameters required for calculating the albedo and vertical distribution of solar fluxes. The paper provides a refined analytical procedure to reduce errors and biases due to the offset errors arising from mounting of the radiometers on the aircraft and due to the aircraft attitude. Measured fluxes have been compared with those derived from a Monte‐Carlo radiative transfer algorithm which can incorporate both gaseous and aerosol components. Under cloud‐free conditions the calculated and measured incoming fluxes agree within 2–10 W m −2 (<1%) depending upon the altitudes. Similarly, the measured and calculated reflected fluxes agreed within 2–5 W m −2 (<5%). The analysis focuses on a cloud‐free day when the air was polluted due to long‐range transport from India, and the mean aerosol optical depth (AOD) was 0.31 and mean single scattering albedo was 0.92. The UAV‐measured absorption AOD was 0.019 which agreed within 20% of the value of 0.024 reported by a ground‐based instrument. The observed and simulated solar absorption agreed within 5% above 1.0 km and aerosol absorption accounted for 30% to 50% of the absorption depending upon the altitude and solar zenith angle. Thus there was no need to invoke spurious or anomalous absorption, provided we accounted for aerosol black carbon. The diurnal mean absorption values for altitudes between 0.5 and 3.0 km above mean sea level were observed to be 41 ± 3 W m −2 (1.5 K/day) in the broadband region and 8 ± 2 W m −2 (0.3 K/day) in the visible region. The contribution of absorbing aerosols to the heating rate was an order of magnitude larger than the contribution of CO 2 and one‐third that of the water vapour. In the lowest 3 km of the tropical atmosphere, aerosols accounted for more than 80% of the atmospheric absorption in the visible region. Copyright © 2007 Royal Meteorological Society
Caval Thrombolysis in Neonates Using Low Doses of Recombinant Human Tissue-Type Plasminogen Activator (1991)

Four neonates suffered caval thrombosis secondary to indwelling central catheters. Dissolution of thrombus with recombinant tissue plasminogen activator (rt-PA) as a low-dose infusion (0.05 mg/kg/hr) directly into thrombus was successful in three patients. rt-PA was ceased after three days in the fourth patient because of catheter malposition. Thrombolysis was achieved between four and ten days. Rethrombosis occurred in one patient despite heparin prophylaxis. Plasminogen activator infusions were titrated to maintain fibrinogen levels above 100 mg/dl. One neonate suffered an intracranial haemorrhage. Regional rt-PA is an alternative to thrombectomy in critically ill neonates.
Tat-tetanus toxin fragment C: a novel protein delivery vector and its use with photochemical internalization (2013)

Protein delivery vectors can be grouped into two classes, those with specific membrane receptors undergoing conventional endocytosis and cell penetrating peptides (CPP) that have the capacity to cross cell or endosomal membranes. For both forms of vectors, translocation across a membrane is usually an inefficient process. In the current study, a novel vector combining the widely used CPP, Tat and the non-toxic neuronal binding domain of tetanus toxin (fragment C or TTC) was assessed for its capacity to deliver GFP as a test cargo protein to human neural progenitor cells (NPCs). These two functional membrane interacting domains dramatically enhanced internalization of the conjugated cargo protein. Tat-TTC-GFP was found to be bound or internalized at least 83-fold more than Tat-GFP and 33-fold more than TTC-GFP in NPCs by direct fluorimetry, and showed enhanced internalization by quantitative microscopy of 18 - and 14-fold, respectively. This preferential internalization was observed to be specific to neuronal cell types. Photochemical internalization (PCI) was utilized to facilitate escape of the endosome-sequestered proteins. The combined use of the Tat-TTC delivery vector with PCI led to both enhancement of neural cell type specific delivery to an endosomal target, followed by the option of efficient release to the cytosol.
NBTI-aware synthesis of digital circuits (2007)

Negative Bias Temperature Instability (NBTI) in PMOS transistors has become a major reliability concern in nanometer scale design, causing the temporal degradation of the threshold voltage of the PMOS transistors, and the delay of digital circuits. A novel method to characterize the delay of every gate in the standard cell library, as a function of the signal probability of each of its inputs, is developed. Accordingly, a technology mapping technique that incorporates the NBTI stress and recovery effects, in order to ensure optimal performance of the circuit, during its entire life-time, is presented. Our technique, demonstrated over 65nm benchmarks shows an average of 10% area recovery, and 12% power savings, as against a pessimistic method that assumes constant stress on all PMOS transistors in the design.
Methodological issues in papers on IFN therapy: time for reappraisal (2000)

We conducted an analytical review of 194 full papers on interferon (IFN) therapy for chronic hepatitis C to evaluate current methodology (i.e. study design, criteria for evaluating the efficacy of therapy and predictors of response). Of the papers evaluated, 64 were randomized controlled trials (RCT), 40 were non-randomized controlled trials (NRCT) and 90 were observational studies (OS). The methodological analysis was focused mainly on clinical trials. The number of patients enrolled in RCT was higher compared with the number enrolled in NRCT. Uniform enrolment criteria were used in less than 50% of the trials. Only 20% of RCT and 2.5% of NRCT used criteria for defining sample size. The response rate was calculated on an intention-to-treat basis in 36 of the RCT and in 14 of the NRCT. The outcome of treatment and the criteria employed to define the response to treatment were found to be far from standardized. In 51.5% of the RCT and 42.5% of the NRCT, normalization of alanine aminotransferase (ALT) level at the end of follow-up was the only marker of response studied. Only 57.6% of the trials considered histological evidence as an important outcome. Among the clinical trials, 71.1% evaluated predictors of good response to IFN therapy. In 51% of the OS, ALT normalization by the end of follow-up was the only criterion for defining response. In conclusion, to ensure a high level of reliability in comparing or combining the results of different studies, some basic general requirements must be followed when planning trials on antiviral therapy.
Substructure of human von Willebrand factor. (1985)

Using electron microscopy, we have visualized the substructure of human von Willebrand factor (vWf) purified by two different approaches. vWf multimers, which appear as flexible strands varying in length up to 2 micron, consist of dimeric units (protomers) polymerized linearly in an end-to-end fashion through disulfide bonds. Examination of small multimers (e.g., one-mers, two-mers, and three-mers) suggests that each protomer consists of two large globular end domains (22 X 6.5 nm) connected to a small central node (6.4 X 3.4 nm) by two flexible rod domains each approximately 34 nm long and approximately 2 nm in diameter. The protomer is 120 nm in length when fully extended. These same structural features are seen both in vWf molecules that were rapidly purified from fresh plasma by a new two-step procedure and in those purified from lyophilized intermediate-purity Factor VIII/vWf concentrates. The 240,000-mol wt subunit observed by gel electrophoresis upon complete reduction of vWf apparently contains both a rod domain and a globular domain and corresponds to one half of the protomer. Two subunits are disulfide-linked, probably near their carboxyl termini, to form the protomer; disulfide bonds in the amino-terminal globular ends link promoters to form vWf multimers. The vWf multimer strands have at least two morphologically distinct types of ends, which may result from proteolytic cleavage in the globular domains after formation of large linear polymers. In addition to releasing fragments that were similar in size and shape to the repeating protomeric unit, plasmic degradation of either preparation of vWf reduced the size of multimers, but had no detectable effect on the substructure of internal protomers.
Transcriptomic profiling of TK2 deficient human skeletal muscle suggests a role for the p53 signalling pathway and identifies growth and differentiation factor-15 as a potential novel biomarker for mitochondrial myopathies (2014)

Our data point towards the tumor suppressor p53 as the regulator at the centre of a network of genes which are responsible for a coordinated response to TK2 mutations which involves inflammation, activation of muscle cell death by apoptosis and induction of growth and differentiation factor 15 (GDF-15) in muscle and serum. We propose that GDF-15 may represent a potential novel biomarker for mitochondrial dysfunction although further studies are required.
TEMPO-oxidized cellulose nanofibers (2010)

Native wood celluloses can be converted to individual nanofibers 3-4 nm wide that are at least several microns in length, i.e. with aspect ratios>100, by TEMPO (2,2,6,6-tetramethylpiperidine-1-oxyl radical)-mediated oxidation and successive mild disintegration in water. Preparation methods and fundamental characteristics of TEMPO-oxidized cellulose nanofibers (TOCN) are reviewed in this paper. Significant amounts of C6 carboxylate groups are selectively formed on each cellulose microfibril surface by TEMPO-mediated oxidation without any changes to the original crystallinity (∼74%) or crystal width of wood celluloses. Electrostatic repulsion and/or osmotic effects working between anionically-charged cellulose microfibrils, the ζ-potentials of which are approximately -75 mV in water, cause the formation of completely individualized TOCN dispersed in water by gentle mechanical disintegration treatment of TEMPO-oxidized wood cellulose fibers. Self-standing TOCN films are transparent and flexible, with high tensile strengths of 200-300 MPa and elastic moduli of 6-7 GPa. Moreover, TOCN-coated poly(lactic acid) films have extremely low oxygen permeability. The new cellulose-based nanofibers formed by size reduction process of native cellulose fibers by TEMPO-mediated oxidation have potential application as environmentally friendly and new bio-based nanomaterials in high-tech fields.
Experimental and numerical studies of the effects of materials and attachment conditions on pellicle induced distortions in advanced photomasks (2002)

Lithography registration errors induced by the attachment of soft pellicles on reticles can significantly affect wafer overlay performance for sub-100 nm lithography chip manufacturing. Intel Corporation and the University of Wisconsin have conducted an extensive study to identify the various sources of pellicle-induced distortions and methods for error reduction in order to meet advanced mask manufacturing requirements. In this study, pellicle attachment processes and system materials were evaluated to determine the effects on image placement accuracy. In particular, the in-plane distortions due to the pellicle attachment technique, pellicle frame flatness, frame adhesive, and environmental temperature were characterized. At Intel, pellicles were attached to a test reticle with a 21 X 21 array of grid points. Registration measurements were conducted before and after pellicle attachment using an optical distance metrology system. A comprehensive finite element model was developed at the University of Wisconsin to assess the contributions to pellicle-induced distortions from individual components of the pellicle system. Pellicle frame flatness, frame adhesive, and temperatures were measured and used as input to the finite element model. The correlation between simulation results and experimental data was excellent. Analyses were also performed to study pellicle mounting mechanisms and pellicle frame flatness.
Sodium Diisopropylamide: Aggregation, Solvation, and Stability (2017)

The solution structures, stabilities, physical properties, and reactivities of sodium diisopropylamide (NaDA) in a variety of coordinating solvents are described. NaDA is stable for months as a solid or as a 1.0 M solution in N,N-dimethylethylamine (DMEA) at -20 °C. A combination of NMR spectroscopic and computational studies show that NaDA is a disolvated symmetric dimer in DMEA, N,N-dimethyl-n-butylamine, and N-methylpyrrolidine. Tetrahydrofuran (THF) readily displaces DMEA, affording a tetrasolvated cyclic dimer at all THF concentrations. Dimethoxyethane (DME) and N,N,N',N'-tetramethylethylenediamine quantitatively displace DMEA, affording doubly chelated symmetric dimers. The trifunctional ligands N,N,N',N″,N″-pentamethyldiethylenetriamine and diglyme bind the dimer as bidentate rather than tridentate ligands. Relative rates of solvent decompositions are reported, and rate studies for the decomposition of THF and DME are consistent with monomer-based mechanisms.
Dual-Homing Based Scalable Partia Multicast Protection (2006)

In this paper, we propose a scalable multicast protection scheme based on a dual-homing architecture where each destination host is connected to two edge routers. Under such an architecture, there are two paths from the source of a multicast session to each destination host, which provides a certain level of protection for the data traffic from the source to the destination host. The protection level varies from 0 percent to 100 percent against a single link failure, depending on the number of shared links between these two paths. The major advantage of the proposed scheme lies in its scalability due to the fact that the protection is provided by constructing a dual-homing architecture at the access network while keeping the routing protocols in the core network unchanged. The selection of dual edge routers plays an important role in enhancing the protection level. Two problems arise for the proposed dual-homing partial multicast protection scheme. One is to calculate the survivability from the source to any pair of edge routers. The other is to assign a pair of edge routers for each destination host such that the total survivability is maximized for the multicast session subject to the port number constraint of each edge router. We propose an optimal algorithm to solve the first problem. We prove the decision version of the second problem is NP-complete and propose two heuristic algorithms to solve it. Simulation results show that the proposed heuristic algorithms achieve performance close to the calculated lower bound
Removal of Mercury from Wastewater by Adsorption Using Thiol-Functionalized Eggshell Membrane (2010)

The thiol-functionalized eggshell membrane (TF-ESM) was prepared by esterification between thioglycolic acid (CH2SHCOOH) and oxygen-containing functional groups on eggshell membrane (ESM). A promising potential biosorbent, TF-ESM, was used for the removal of toxic mercury in wastewater. Aqueous of mercury ions removing properties by TF-ESM were studied through batch experiments. The results indicated that the modified ESM has greatly enhanced the adsorption capacity for Hg2+, the maximum capacity was increased more than 3-fold in comparison with the unmodified ESM, from 19.4 mg g-1 to 71.9 mg g-1. The optimum of pH value for Hg adsorption was in the range of 2-8, which the removing rate over 96%. The results obtained show that the novel thiol-functionalized eggshell membrane performed well the removal and recovery of mercury from low concentration wastewaters.
Ethoxylated rapeseed oil derivatives as novel adjuvants for herbicides (2002)

Ethoxylates of rapeseed oil and of methylated rapeseed oil were synthesized and tested as adjuvants for 2,4-D and phenmedipham. Provided they had less than 6 units of ethylene oxide (EO), 1.0 to 10 g litre(-1) ethoxylates in water induced droplet spreading on barley leaves. In an acetone-based medium all derivatives strongly promoted the foliar uptake of 2,4-D, with no clear influence of the ethoxylation degree. In the same medium there was a negative influence of ethoxylate chain length on the foliar uptake of phenmedipham. In a water-based medium, phenmedipham applied with rapeseed oil emulsified with ethoxylated (20 EO) rapeseed oil displayed uptake rates close to a commercial preparation. The same was true for phenmedipham applied with ethoxylated (2 EO) methylated rapeseed oil. In bioassays, phenmedipham prepared with methylated rapeseed oil emulsified with ethoxylated (20 EO) rapeseed oil was as efficacious on barley as a commercial formulation. The same was true for phenmedipham prepared with ethoxylated (2 EO) methylated rapeseed oil. However, neither rapeseed oil nor methylated rapeseed oil emulsified with ethoxylated (2 EO) methylated rapeseed oil conferred good efficacy to phenmedipham. Hence, ethoxylated rapeseed oil derivatives are promising adjuvants or formulants for herbicides.
Reflections on Burke, Kant, and<i>Solitude and the Sublime</i> (2012)

This essay reviews Edmund Burke's and Immanuel Kant's views on the sublime as the author had earlier addressed them in Solitude and the Sublime. Her reflections focus on the importance of the rise of interest in aesthetics as a distinctive kind of experience in the eighteenth century and the Romantic era, on how aesthetic experience (in Kant's view) sits in relation to pure reason and practical reason, on the importance of aesthetic experience in recruiting first-person testimony, and on the importance of aesthetic discussions for emphasizing, first, the necessity that aesthetic experience be a response to an actual concrete object (in the beautiful) and, second, the significance of the mathematical sublime in showing human representational capacities themselves as objects of aesthetic experience.