gebhart/patrepeval huggingface dataset:
Cell cycle dependent association of c-myc protein with the nuclear matrix. (1991)

We demonstrate the presence of a c-myc protein with an apparent molecular weight of 67 kd in the lower eukaryote Physarum polycephalum with polyclonal and monoclonal anti-c-myc-antibodies. It is shown that the amount of myc protein present in the nucleus does not fluctuate during the naturally synchronous cell cycle of Physarum. The myc protein remains firmly associated with the nuclear matrix after a variety of matrix preparation procedures. Although the level of c-myc protein is invariant during the cell cycle, the matrix-bound portion of c-myc protein is higher during S-phase as compared to G2-period. In immunoelectron microscopy the immunosignal was considerably stronger in the nuclear matrix compared with unfractionated nuclei, indicating increased accessibility of c-myc protein in nuclear scaffold structures. We show that the nuclear localization of c-myc protein changes during the cell cycle, being transiently but specifically bound to the periphery of the nuclear matrix structure during S-phase.
Synthesis and Lateral Root-Inducing Activity of 3-Hydroxymethyl-2-Substituted-4-Butanolides (2000)

Aseeris3-hy)xyhy1-2-subse(i-4-bak()ds ws syheszed ad evaluate(i for their activity to induce lateral root il1 the lettuce seedhngs 2-Benzy3-hydroxymethyl-4-butaRolide stimuated the emergenee of lateral root while the 2-alkanoyl and 2(a-hydroxybenzyl) analogs had no activity indicating that the 2-benzoyl moiety was essential for ateral root-inducing aetivity Among the compounds tested so far 3-hydroxy-raethy2(3-raethxybemaoy)4-balideshweehaciviy
ChemInform Abstract: SYNTHESIS, CHARACTERIZATION AND REACTIVITY OF THE DINUCLEAR TUNGSTEN COMPLEXES (ET4N)2(W2(CO)8(SR)2) (1985)

Abstract Die durch die aufgezeichnete äquivalente Reaktion gebildeten Titelkomplexe (IIIa) werden durch Analysen, spektroskopische Daten und cyclovoltammetrische Untersuchungen charakterisiert.
Plug-and-play sensors in wireless networks (2001)

The availability of these self-configuring networks of wireless sensor data will accelerate the ongoing trend toward automation ranging from the factory floor to the office to the warehouse and outdoors. Lower installation costs, lower operating costs, and the improved factory efficiency will provide significant cost savings. Technicians will be able to walk near a machine and obtain data on its existing state and its history, enabling better monitoring of the equipment condition and avoiding expensive downtime. Open standards like Bluetooth and IEEE 1451 are key to supporting the proliferation of these technologies.
Hypercomplex Iterations: Distance Estimation and Higher Dimensional Fractals (2002)

This book is based on the authors' research on rendering images of higher dimensional fractals by a distance estimation technique. It is self-contained, giving a careful treatment of both the known techniques and the authors' new methods. The distance estimation technique was originally applied to Julia sets and the Mandelbrot set in the complex plane. It was justified, through the work of Douady and Hubbard, by deep results in complex analysis. In this book, the authors generalise the distance estimation to quaternionic and other higher dimensional fractals, including fractals derived from iteration in the Cayley numbers (octonionic fractals). The generalization is justified by new geometric arguments that circumvent the need for complex analysis. This puts on a firm footing the authors' present work and the second author's earlier work with John Hart and Dan Sandin. The results of this book will be of great interest to mathematicians and computer scientists interested in fractals and computer graphics
Renal Cell Carcinoma (1999)

Diagnosis of renal cell carcinoma (RCC) is established using sonography and confirmation by computed tomography (CT). Due to the widespread use of these imaging techniques for numerous indications, small renal tumors are increasingly detected by chance. As the sensitivity of CT is very high, treatment of RCC is routinely initiated without histological confirmation. Standard therapy of locally confined tumors without evidence of lymph node or hematogenic metastases is nephrectomy. However, the results of tumor excision equal those of nephrectomy if tumor size does not exceed 4 cm in diameter. Whereas the prognosis of organ-confined tumors is excellent, no curative treatment for primary metastasized RCC is available to date. Immunotherapy - the only systemic treatment modality with clinically relevant response rates - has so far failed to effect a survival advantage for the patient. Surgery is only potentially curative for asychronous metastases occurring more than 2 years after surgery.
Organic – Inorganic Nano-Hybrid Materials [Translated]<sup>†</sup> (2007)

Nano-ordered composite materials consisting of organic polymers and inorganic materials have been attracting attention for the purpose of the creation of high-performance or high-functional polymeric materials. Especially, the word of “polymer hybrid” claims the blends of organic and inorganic components at nano-level dispersion. By using this idea, an enhancement of mechanical strength of organic polymers with silica particles is possible. High transparency of this material is another important property and indispensable for development of optical waveguides, optical biosensors, non-linear optical materials, and contact lenses. Hybrid materials are also potential candidates for catalysts and gas separation membranes.The sol-gel reaction makes possible to incorporate the organic polymer segments in the network matrix of inorganic materials. The high homogeneity of the hybrid strongly suggests that the organic polymer segments and inorganic one are blended at the nano-meter level. The organic polymer nano-hybrids can be considered not only as the combination of organic polymer and inorganic materials, but as quite new materials.† This paper, published originally in Japanese in The Micrometrics, 50, 11-15 (2006/2007), is published in KONA with the permission of the editorial committee of the Micrometrics.
CD14+ cells in granulocyte colony-stimulating factor (G-CSF)-mobilized peripheral blood mononuclear cells induce secretion of interleukin-6 and G-CSF by marrow stroma (1996)

The ability of granulocyte colony-stimulating factor (G-CSF)-mobilized peripheral blood mononuclear cells (G-PBMCs) to induce secretion of cytokines in primary long-term marrow cultures (LTC) or in the human marrow stromal cell line HS23 was compared with that of marrow mononuclear cells. Equal numbers of G-PBMCs or marrow mononuclear cells were added to stromal cultures, supernatants were harvested at day 4 and levels of interleukin-1 alpha (IL-1 alpha), IL-1 beta, IL-2, IL-6, G-CSF, and tumor necrosis factor alpha (TNF alpha) were determined. G-PBMCs induced 21.4-fold higher levels of IL-6 and 12.5-fold higher levels of G-CSF in LTC cocultures compared with marrow mononuclear cells and induced 20.6-fold more IL-6 and 6.3-fold more G-CSF when added to HS23 cells. Experiments using sorted populations of CD20+, CD3+, and CD14+ cells showed that CD14+ cells within G-PBMCs were responsible for triggering the production of IL-6 and G-CSF. The effect did not require cell-cell contact and was inhibited when neutralizing antibodies to IL-1 alpha and IL-1 beta were used in combination. In these experiments, the greater stimulating ability of G-PBMCs is most likely attributable to the greater number of CD14+ cells in G-PBMCs (26.1+% +/- 2.3%) compared with marrow (2.5% +/- 0.8%), because equal numbers of CD14+ cells sorted from marrow and G-PBMCs showed comparable ability to induce IL-6 and G-CSF when placed directly on stromal cells.
Hybrid control of BCM soft-switching three phase micro-inverter (2012)

A new hybrid control of soft switching boundary conduction mode (BCM) inverter that features an easy digital implementation and reduced number of analog components is presented in this paper. A traditional half-bridge three-phase inverter topology can realize soft switching through implementing BCM operation, thus no additional power devices or magnetic components are required. The proposed hybrid method facilitates the control of BCM inverter by taking full advantage of the DSP resources. The simulation was carried out to verify the proposed control technique. A brief analysis of current modulation of soft switching BCM inverter is given in the paper. A 400W 120Vac three-phase prototype was built. The experimental results show that the soft switching can be realized under different load conditions and the peak efficiency can reach up to 96.5%.
The mitotic serine threonine kinase, <i>Aurora-2</i>, is a potential target for drug development in human pancreatic cancer (2004)

Aurora-2 is a serine threonine kinase that associates with the centrosome. Overexpression or ectopic expression of Aurora-2 appears to alter centrosome number and function and has been implicated in a variety of human cancers. In this work, we demonstrate that Aurora-2 is both amplified and overexpressed in human pancreatic cancer cell lines, with a 2-5-fold increase in gene copy number and a 3-4-fold increase in protein levels compared with controls. Aurora-2 is also amplified and overexpressed in pancreatic cancers taken directly from patients. An immunohistochemistry of tissues taken directly from patients demonstrated an overexpression of Aurora-2 in 26 of 28 pancreatic cancers compared with 18 normal pancreas samples. Antisense nucleotides specifically targeted at Aurora-2 arrest the cell cycle in pancreatic cancer cells, indicating the potential of Aurora-2 as a therapeutic target in pancreatic cancer.
Metabolic and Redox Signaling of the Nucleoredoxin-Like-1 Gene for the Treatment of Genetic Retinal Diseases (2020)

The loss of cone photoreceptor function in retinitis pigmentosa (RP) severely impacts the central and daily vision and quality of life of patients affected by this disease. The loss of cones follows the degeneration of rods, in a manner independent of the causing mutations in numerous genes associated with RP. We have explored this phenomenon and proposed that the loss of rods triggers a reduction in the expression of rod-derived cone viability factor (RdCVF) encoded by the nucleoredoxin-like 1 (<i>NXNL1</i>) gene which interrupts the metabolic and redox signaling between rods and cones. After providing scientific evidence supporting this mechanism, we propose a way to restore this lost signaling and prevent the cone vision loss in animal models of RP. We also explain how we could restore this signaling to prevent cone vision loss in animal models of the disease and how we plan to apply this therapeutic strategy by the administration of both products of <i>NXNL1</i> encoding the trophic factor RdCVF and the thioredoxin enzyme RdCVFL using an adeno-associated viral vector. We describe in detail all the steps of this translational program, from the design of the drug, its production, biological validation, and analytical and preclinical qualification required for a future clinical trial that would, if successful, provide a treatment for this incurable disease.
Improved Fracturing Technologies Provide for Increased Well Productivity: A Case Study on Red Fork Formation Wells (1995)

ABSTRACT A case study has been conducted on Red Fork formation wells with bottomhole temperatures ranging from 225°-250°F. The fracturing applications and techniques in this area had historically provided lower than expected posttreatment productivity and a rapid decline rate, suggesting that the fracture conductivity were less than optimum. Joint efforts of the operator and service company, utilizing state-of-the-art fluids, breakers, and design methodologies, were employed to optimize well productivity. The case histories of hydraulic fracturing treatments and subsequent production performance of five offset wells are analyzed and presented. Average incremental production rates were significantly improved through application of the new technologies, clearly demonstrating the effectiveness of the modifications.
The PINT Profile of SIP and SDP: a Protocol for IP Access to Telephone Call Services (1999)

Our results demonstrated that PSADVR improved the PCa detection rate on second biopsies, especially for mid-to-high-risk cancers requiring prompt treatment.
Decay of the IS <i>10</i> antisense RNA by 3′ exoribonucleases: evidence that RNase II stabilizes RNA‐OUT against PNPase attack (1994)

RNA-OUT, the 69-nucleotide antisense RNA that regulates Tn10/IS10 transposition folds into a simple stem-loop structure. The unusually high metabolic stability of RNA-OUT is dependent, in part, on the integrity of its stem-domain: mutations that disrupt stem-domain structure (Class II mutations) render RNA-OUT unstable, and restoration of structure restores stability. Indeed, there is a strong correlation between the thermodynamic and metabolic stabilities of RNA-OUT. We show here that stem-domain integrity determines RNA-OUT's resistance to 3' exoribonucleolytic attack: Class II mutations are almost completely suppressed in Escherichia coli cells lacking its principal 3' exoribonucleases, ribonuclease II (RNase II) and polynucleotide phosphorylase (PNPase). RNase II and PNPase are individually able to degrade various RNA-OUT species, albeit with different efficiencies: RNA-OUT secondary structure provides greater resistance to RNase II than to PNPase. Surprisingly, RNA-OUT is threefold more stable in wild-type cells than in cells deficient for RNase II activity, suggesting that RNase II somehow lessens PNPase attack on RNA-OUT. We discuss how this might occur. We also show that wild-type RNA-OUT stability changes only two-fold across the normal range of physiological growth temperatures (30-44 degrees C) in wild-type cells, which has important implications for IS10 biology.
AQuA: an adaptive architecture that provides dependable distributed objects (2002)

Dependable distributed systems are difficult to build. This is particularly true if they have dependability requirements that change during the execution of an application, and are built with commercial off-the-shelf hardware. In that case, fault tolerance must be achieved using middleware software, and mechanisms must be provided to communicate the dependability requirements of a distributed application to the system and to adapt the system's configuration to try to achieve the desired dependability. The AQuA architecture allows distributed applications to request a desired level of availability using the Quality Objects (QuO) framework and includes a dependability manager that attempts to meet requested availability levels by configuring the system in response to outside requests and changes in system resources due to faults. The AQuA architecture uses the QuO runtime to process and invoke availability requests, the Proteus dependability manager to configure the system in response to faults and availability requests, and the Ensemble protocol stack to provide group communication services. Furthermore, a CORBA interface is provided to application objects using the AQuA gateway. The gateway provides a mechanism to translate between process-level communication, as supported by Ensemble, and IIOP messages, understood by Object Request Brokers. Both active and passive replication are supported, and the replication type to use is chosen based on the performance and dependability requirements of particular distributed applications.
Adaptive multiple texture approach to texture packing for 3D video games (2007)

This paper presents an adaptive multiple texture approach to the problem of texture packing for 3D video games. In modern graphics hardware, texture size is typically constrained to width and height dimensions that are powers of two. To reduce the texture management overhead caused by storing individual textures, texture packing algorithms are used to pack multiple textures into a single powers-of-two texture. Current texture packing techniques are very limiting as they are capable of packing textures only into a single texture of predefined size. This can result in significant wasted texture space due to the powers-of-two texture size restrictions. In the proposed technique, individual arbitrarily sized rectangular textures are packed into multiple textures in an adaptive manner. This approach reduces the amount of wasted texture space in a more efficient manner by adaptively determining the quantity as well as size of textures being used during the packing process. Experimental results demonstrate the effectiveness of this technique in packing textures in an efficient and automated fashion. This makes it well suited for improving texture management in future 3D video games, where resources are limited and a high frame rate needs to be achieved to provide a truly immersive experience.
In March 2009, SARS wants their money earlier : tax payments (2009)

Proposed amendments to the income tax and VAT Acts allow Trevor to ask for your March payments two days earlier.
Virtual Colonoscopy Screening With Ultra Low-Dose CT and Less-Stressful Bowel Preparation: A Computer Simulation Study (2008)

Computed tomography colonography (CTC) or CT-based virtual colonoscopy (VC) is an emerging tool for detection of colonic polyps. Compared to the conventional fiber-optic colonoscopy, VC has demonstrated the potential to become a mass screening modality in terms of safety, cost, and patient compliance. However, current CTC delivers excessive X-ray radiation to the patient during data acquisition. The radiation is a major concern for screening application of CTC. In this work, we performed a simulation study to demonstrate a possible ultra low-dose CT technique for VC. The ultra low-dose abdominal CT images were simulated by adding noise to the sinograms of the patient CTC images acquired with normal dose scans at 100 mAs levels. The simulated noisy sinogram or projection data were first processed by a Karhunen-Loève domain penalized weighted least-squares (KL-PWLS) restoration method and then reconstructed by a filtered backprojection algorithm for the ultra low-dose CT images. The patient-specific virtual colon lumen was constructed and navigated by a VC system after electronic colon cleansing of the orally-tagged residue stool and fluid. By the KL-PWLS noise reduction, the colon lumen can successfully be constructed and the colonic polyp can be detected in an ultra low-dose level below 50 mAs. Polyp detection can be found more easily by the KL-PWLS noise reduction compared to the results using the conventional noise filters, such as Hanning filter. These promising results indicate the feasibility of an ultra low-dose CTC pipeline for colon screening with less-stressful bowel preparation by fecal tagging with oral contrast.
Sustainable liquid biofuels and their environmental impact (2007)

Abstract In whatever measure liquid biofuels are produced, they avoid the use of politically and economically unstable petroleum. However, there has been much debate regarding their environmental impact and sustainability. Corn ethanol manufacturing uses large quantities of fossil fuels, which, although locally produced, create doubt on whether its continual use will bring any clear economic and environmental benefits. On the other hand, biodiesel, because it enjoys a simpler and thus efficient manufacturing process, shows more clarity as to the environmental benefits it provides, but its sustainability at a significant scale is not clear due to the low productivity of its crops. Brazil's ethanol industry, which is based on sugarcane, has shown that it is possible to be efficient, both environmentally and economically in the implementation of a biofuel infrastructure. Very akin to sugarcane ethanol technology is cellulosic ethanol. A cellulosic ethanol infrastructure can make use of crops that have higher productivities and lower environmental impact. In addition, the conversion process uses very little fossil fuels, which makes it even more sustainable and environmentally benign. This article describes the infrastructure necessary for the implementation of sustainable biofuels, discusses their projected benefits, their environmental impact, and the logistics needed for their sustainability. © 2007 American Institute of Chemical Engineers Environ Prog, 2007
Experimental and theoretical stability analysis of complex-coupled DFB laser diodes with and without external feedback (1996)

These Ecole polytechnique federale de Lausanne EPFL, n° 1475 (1996) Reference doi:10.5075/epfl-thesis-1475Print copy in library catalog Record created on 2005-03-16, modified on 2016-08-08
A novel on-line state-of-charge estimation algorithm for valve regulated lead-acid batteries used in hybrid electric vehicles (2007)

A four state reconfigurable battery state of charge estimation algorithm combining the open circuit voltage (OCV) and its estimation and current integration is proposed in the present paper. In general, the open circuit voltage requires a few hours to become completely stabilized, when 100% confidence indicator is obtained. The proposed algorithm in its first state, works when the battery current is zero and 5 minutes within the OCV estimation process. For the second state, during constant current charging the battery state-of-charge (SOC) estimation is based on the previously measured look-up table that stores the battery voltage versus battery state-of-charge. In the third state the battery SOC is estimated by battery charging voltage vs. charging current characteristic stored in a look-up table. Finally, for the fourth state, during variable discharging current and regenerative breaking the battery SOC is estimated by current integration method. The four states of the estimation algorithm are self-identifiable and from here the reconfigurability property. The proposed algorithm is amply documented by experiments on a 48 Vdc, 55 Ah battery pack typical for mild hybrid electric vehicles.
[Comparison of the efficacy of verapamil and diltiazem in stable exercise angina. A double-blind and crossover study]. (1990)

Calcium channel blockers are now recommended for the treatment of stable angina but few studies have been carried out comparing the efficacy of verapamil and diltiazem in this indication. The short-term efficacy of these two drugs was compared in a double-blind crossover trial in 12 patients. The following protocol was used, 24 hour selection period followed by two crossover treatment periods versus double placebo. Exercise stress tests were performed 2 hours after the last dose at the end of each treatment period. Each patient underwent 3 stress tests: the first during the selection period whilst taking verapamil and diltiazem placebo (ET0), the second after the first treatment period at day 7 (ET1) and the third after the second treatment period at day 14 (ET2). A comparison of exercise capacity (ET0 to ET1 and ET2) showed improved effort tolerance and an increase in the ischaemic threshold with calcium blocker therapy. The duration of effort, the maximum sustained load, the rate-pressure product and the time to ST depression were all significantly increased. On the other hand, there were no significant changes in the percentage theoretical maximum heart rate attained, the heart rate at which ST depression occurred, the maximum ST depression and the incidence of angina. A comparison between ET1 and ET2 did not show any difference in the parameters of maximum effort or of the appearance of myocardial ischaemia. The comparison of exercise stress tests performed after treatment with verapamil and after diltiazem showed that the total duration of exercise, the maximum sustained load (in watts) and the rate-pressure product were identical.(ABSTRACT TRUNCATED AT 250 WORDS)