gebhart/patrepeval huggingface dataset:
An approach to canine behavioural genetics employing guide dogs for the blind (2009)

The purpose of this study was to attempt to find related variables of the canine genome with behavioural traits of dogs maintained and tested in a guide dog facility which provided a relatively uniform environment. The study involved 81 Labrador Retrievers that were being trained as guide dogs. Each dog was taken on walk-out sessions in which the trainer weekly recorded observations that were related to behavioural traits. The records were subjected to key-word analysis of 14 behaviour-related words. A factor analysis on the appearance rate of the 14 key words or phrases resulted in the extraction of six factors that accounted for 67.4% of the variance. Factor 1, referred to as aggressiveness, was significantly related to the success or failure of the dog in qualifying as a guide dog, and was also related to the variable of litter identification. Factor 2, referred to as distraction, was related to the variable of trainer. Factor 3, activity level, was related to the variable of sex, and was significantly related to the polymorphisms of c.471T>C in the solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter) member 2 gene and c.216G>A in the catechol-O-methyltransferase gene. The involvement of polymorphisms c.471T>C and c.216G>A in behavioural patterns related to activity level is similar to comparable genetic studies in other mammalian species. These results contribute to a greater understanding of the role of these genes in behaviour.
Transplacentally Acquired Antiviral Antibodies and Outcome in Congenital Human Cytomegalovirus Infection (1996)

The association between transplacentally acquired maternal antibodies and outcome in congenital human cytomegalovirus (HCMV) infection was investigated by analyzing antiviral antibodies in the cord blood from infants with permanent neurologic sequelae and from those without sequelae. Higher levels of antiglycoprotein B and neutralizing antibodies were observed in infants with sequelae. Infants with symptomatic infection and those with > or = 2 sequelae had higher levels of virus binding antibodies. No association between neutralizing titers and progressive hearing loss was noted. These results suggested that the development of sequelae following congenital HCMV infection was not associated with measurable deficits in the maternal antiviral antibody response. Higher levels of anti-gB and neutralizing antibodies in infants with sequelae also suggested that the natural history of this congenital infection is unlikely to be modified by the passive administration of antiviral antibodies in the postnatal period.
Introduction to Information Theory and Data Compression (2003)

An effective blend of carefully explained theory and practical applications, this text imparts the fundamentals of both information theory and data compression. Although the two topics are related, this unique text allows either topic to be presented independently, and it was specifically designed so that the data compression section requires no pr
Self‐curable system of an aqueous‐based polyurethane dispersion via a ring‐opening reaction of azetidine end groups (2006)

Abstract An azetidine (AZT) containing compound, 3‐azetidinyl propanol was synthesized from methyl acrylate with 3‐amino‐1‐propanol in a four‐step reaction. It was introduced into an isocyanate‐terminated carboxylic acid containing polyurethane (PU) prepolymer as the end group. A single‐component, AZT‐terminated self‐curable aqueous‐based PU dispersion was obtained from the water dispersion process after it was neutralized with triethylamine. Its carboxylic groups served not only as the internal emulsifier stabilizing the aqueous PU dispersion but also as PU self‐curing sites toward its AZT end groups via a ring‐opening reaction. The curing reaction took place on drying and resulted in polymeric network structure formation among the polymers. The performance properties of this self‐cured PU were evaluated in this study. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 102: 4383–4393, 2006
Tissue-Specific Glucocorticoid Reactivating Enzyme, 11β-Hydroxysteoid Dehydrogenase Type 1 (11β-HSD1) - A Promising Drug Target for the Treatment of Metabolic Syndrome (2003)

Obesity is closely associated with the Metabolic Syndrome, which includes insulin resistance, glucose intolerance, dyslipidemia and hypertension. The best predictor of these morbidities is not the total body fat mass but the quantity of visceral (e.g. omental, mesenteric) fat. Glucocorticoids play a pivotal role in regulating fat metabolism, function and distribution. Indeed, patients with Cushing-s syndrome (a rare disease characterized by systemic glucocorticoid excess originating from the adrenal or pituitary tumors) or receiving glucocorticoid therapy develop reversible visceral fat obesity. The role of glucocorticoids in prevalent forms of human obesity, however, has remained obscure, because circulating glucocorticoid concentrations are not elevated in the majority of obese subjects. Glucocorticoid action on target tissue depends not only on circulating levels but also on intracellular concentration. Locally enhanced action of gluccorticoids in adipose tissue and skeletal muscle has been demonstrated in the Metabolic Syndrome. Evidence has accumulated that enzyme activity of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1), which regenerates active glucocorticoids from inactive forms and plays a central role in regulating intracellular glucocorticoid concentration, is commonly elevated in fat depots from obese individuals. This suggests a role for local glucocorticoid reactivation in obesity and the Metabolic Syndrome. 11beta-HSD1 knockout mice resist visceral fat accumulation and insulin resistance even on a high-fat diet. Furthermore, fat-specific 11beta-HSD1 transgenic mice, those have increased enzyme activity to a similar extent seen in obese humans, develop visceral obesity with insulin and leptin resistance, dyslipidemia and hypertension. In adipocytes, both antidiabetic PPARgamma agonists and LXRalpha agonists significantly reduce 11beta-HSD1 mRNA and enzyme activity, suggesting that suppression of 11beta-HSD1 in adipose tissue may be one of the mechanisms by which these drugs exert beneficial metabolic effects. Recently reported selective inhibitors of 11beta-HSD1 can ameliorate severe hyperglycemia in the genetically diabetic obese mice. In summary, 11beta-HSD1 is a promising pharmaceutical target for the treatment of the Metabolic Syndrome.
In Vivo Visualization of Bacterial Colonization, Antigen Expression, and Specific T-Cell Induction following Oral Administration of Live Recombinant<i>Salmonella enterica</i>Serovar Typhimurium (2001)

Live attenuated Salmonella strains that express a foreign antigen are promising oral vaccine candidates. Numerous genetic modifications have been empirically tested, but their effects on immunogenicity are difficult to interpret since important in vivo properties of recombinant Salmonella strains such as antigen expression and localization are incompletely characterized and the crucial early inductive events of an immune response to the foreign antigen are not fully understood. Here, methods were developed to directly localize and quantitate the in situ expression of an ovalbumin model antigen in recombinant Salmonella enterica serovar Typhimurium using two-color flow cytometry and confocal microscopy. In parallel, the in vivo activation, blast formation, and division of ovalbumin-specific CD4(+) T cells were followed using a well-characterized transgenic T-cell receptor mouse model. This combined approach revealed a biphasic induction of ovalbumin-specific T cells in the Peyer's patches that followed the local ovalbumin expression of orally administered recombinant Salmonella cells in a dose- and time-dependent manner. Interestingly, intact Salmonella cells and cognate T cells seemed to remain in separate tissue compartments throughout induction, suggesting a transport of killed Salmonella cells from the colonized subepithelial dome area to the interfollicular inductive sites. The findings of this study will help to rationally optimize recombinant Salmonella strains as efficacious live antigen carriers for oral vaccination.
THE EFFECT OF OSMOTIC PRESSURE ON THE PRODUCTION AND EXCRETION OF ETHANOL AND GLYCEROL BY A BREWING YEAST STRAIN* (1980)

When the cells of a lager brewing yeast Saccharomyces uvarum (carlsbergensis) were grown in minimal media containing sucrose and a non-metabolized sugar sorbitol, significant levels of intracellular ethanol were obtained. Intracellular ethanol concentration decreased as the osmotic pressure of the medium was lowered and the proportion of extracellular ethanol increased. A reduction in cell viability occurred when there were high levels of intracellular ethanol. The total amount of glycerol produced increased with increased osmotic pressure, but glycerol diffused out of the cells faster than ethanol.
iSeeYou: disabling the MacBook webcam indicator LED (2014)

The ubiquitous webcam indicator LED is an important privacy feature which provides a visual cue that the camera is turned on. We describe how to disable the LED on a class of Apple internal iSight webcams used in some versions of MacBook laptops and iMac desktops. This enables video to be captured without any visual indication to the user and can be accomplished entirely in user space by an unprivileged (non-root) application.

The same technique that allows us to disable the LED, namely reprogramming the firmware that runs on the iSight, enables a virtual machine escape whereby malware running inside a virtual machine reprograms the camera to act as a USB Human Interface Device (HID) keyboard which executes code in the host operating system.

We build two proofs-of-concept: (1) an OS X application, iSeeYou, which demonstrates capturing video with the LED disabled; and (2) a virtual machine escape that launches Terminal.app and runs shell commands. To defend against these and related threats, we build an OS X kernel extension, iSightDefender, which prohibits the modification of the iSight's firmware from user space.
Thermal Aspects and Static/Dynamic Protrusion Behaviors in Heat-Assisted Magnetic Recording (2014)

The pressure of increasing the areal density of magnetic storage media demands the leap to new storage technologies. Among the prime candidates, available is heat-assisted magnetic recording technology. Among many aspects available in this paper, we will focus on newly introduced thermal aspects and protrusions due to additional heat sources in the recording head and recording media. As needed with the existing head protrusions such as thermal flying height control and writer pole tip protrusion, we will present the data, which is based on thermomechanical modeling and experiments during flying and static conditions. The ongoing debate of comparing flying versus nonflying conditions remains a critical issue but needs to be accepted as an imperfect but valuable way of exploring the new protrusion effects. We will address the important issue of the differences between the pure thermal and the associated mechanical time constants.
Study of a boundary layer problem in elastic composite materials (1986)

avec les conditions gnrales d'utilisation (
An English to Korean transliteration model of extended Markov window (2000)

Automatic transliteration problem is to transcribe foreign words in one's own alphabet. Machine generated transliteration can be useful in various applications such as indexing in an information retrieval system and pronunciation synthesis in a text-to-speech system. In this paper we present a model for statistical English-to-Korean transliteration that generates transliteration candidates with probability. The model is designed to utilize various information sources by extending a conventional Markov window. Also, an efficient and accurate method for alignment and syllabification of pronunciation units is described. The experimental results show a recall of 0.939 for trained words and 0.875 for untrained words when the best 10 candidates are considered.
Reduced dopamine D 3 receptor expression in blood lymphocytes of smokers is negatively correlated with daily number of smoked cigarettes: A peripheral correlate of dopaminergic alterations in smokers (2004)

The mesolimbic dopaminergic system is known to mediate rewarding effects of nicotine administration, and dysfunctions of this system may underlie failure to stop cigarette smoking. Expression of dopamine receptors in peripheral blood lymphocytes (PBLs) has been indicated as a peripheral correlate of brain status. Dopamine receptor D(3) (DRD3) and D(4) (DRD4) mRNA expression in PBLs was measured by real-time polymerase chain reaction in smokers (n=26) and former smokers (n=14), compared with nonsmoking control subjects (n=35). A significant (p=.032, Bonferroni corrected) 30% reduction of DRD3 mRNA expression in PBLs was found in smokers but not former smokers in comparison with controls. DRD3 mRNA expression in PBLs in smokers but not former smokers was negatively correlated with daily number of cigarettes consumed (Pearson correlation coefficient r=-.54, p=.005). These data suggest a selective inhibiting effect of smoking on DRD3 mRNA expression and, with the known involvement of DRD3 in reward mediation, indicates a vicious-cycle explanation for the motivation for continued smoking.
Design of a small pneumatic walking robot (1995)

Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1995.
A multi-antigen vaccine in combination with an immunotoxin targeting tumor-associated fibroblast for treating murine melanoma (2016)

A therapeutically effective cancer vaccine must generate potent antitumor immune responses and be able to overcome tolerance mechanisms mediated by the progressing tumor itself. Previous studies showed that glycoprotein 100 (gp100), tyrosinase-related protein 1 (TRP1), and tyrosinase-related protein 2 (TRP2) are promising immunogens for melanoma immunotherapy. In this study, we administered these three melanoma-associated antigens via lentiviral vectors (termed LV-3Ag) and found that this multi-antigen vaccine strategy markedly increased functional T-cell infiltration into tumors and generated protective and therapeutic antitumor immunity. We also engineered a novel immunotoxin, αFAP-PE38, capable of targeting fibroblast activation protein (FAP)-expressing fibroblasts within the tumor stroma. When combined with αFAP-PE38, LV-3Ag exhibited greatly enhanced antitumor effects on tumor growth in an established B16 melanoma model. The mechanism of action underlying this combination treatment likely modulates the immune suppressive tumor microenvironment and, consequently, activates cytotoxic CD8+ T cells capable of specifically recognizing and destroying tumor cells. Taken together, these results provide a strong rationale for combining an immunotoxin with cancer vaccines for the treatment of patients with advanced cancer.
Tumor quantitation and monitoring in whole-body planar technetium-99m-sestamibi imaging. (1997)

Our method represents an objective, quantitative tool to measure tumor activity in sequential whole-body scintigraphic images, and may help assess tumor response to chemotherapy or radiation therapy.
Lipid profiling for early diagnosis and progression of colorectal cancer using direct‐infusion electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry (2012)

Our study revealed that the consideration of CRC stages would be necessary in diagnostic biomarker discovery, as well as that attention should be paid to the facile loss of methyl chloride from the [M + Cl](-) form of LPC(16:0) in its tandem mass spectrum.
Trip Based Optimal Power Management of Plug-in Hybrid Electric Vehicle with Advanced Traffic Modeling (2008)

<div class="htmlview paragraph">The plug-in hybrid electric vehicles (PHEV), utilizing more battery power, has become a next-generation HEV with great promise of higher fuel economy. A nearly global optimization based charge-depletion control strategy is developed for PHEV power management by using the Intelligent Transportation Systems (ITS). Trip model is obtained via GPS, GIS, real-time and historical traffic flow data and advanced traffic flow modeling. The Gipps car-following model [<span class="xref">42</span>] is used for the local road trip modeling along with the synchronization of the traffic signal sequences. The gas-kinetic model [<span class="xref">53</span>] was used for the freeway trip modeling. These trip modeling schemes are validated with simulation.</div>
The Avatars of virtual representation: an assessment of the Burkean notion's contemporary relevance (2010)

This article examines the way in which contemporary recent research on virtual representation has taken up both Edmund Burke's original articulation of the concept, and its important complications. The conceptual structure of virtual representation cannot by itself edify us on its potential, and its normative and institutional implications are best understood within two distinct approaches to democracy and representation: an adversarial democracy account, or a tradition of unitary representation.
[Regulatory role of HTm4 gene in hematopoietic cell cycle]. (2005)

Cell cycle progression is tightly regulated in hematopoietic stem cells. The cycle state decides cells' fates, which includes self-renewal, proliferation and differentiation. Proper cell cycle regulation is a pivotal element for the maintenance of hematopoiesis homeostasis. HTm4 is a newly identified specific cell cycle regulator of the hematopoietic cell. Through interacting with KAP-CDK2 complex, it arrests cells in G(0)/G(1) phase. K562 is a human chronic myelogenous leukemia cell; it could be induced to megakaryoblast by phorbol 12-myristate 13-acetate (PMA). Such differentiation must be associated with cell cycle change. To further clarify HTm4's function in hematopoietic cell cycle regulation, K562 cells were treated with PMA. Cell cycle change was analysed using flow cytometric system. And during the induction process gene expression of HTm4 as well as CycleE and CDK2, which are responsible for G(1) to S transition, were analysed using semi-quantitative RT-PCR. The C-terminal domain of HTm4 protein has been shown to be important for HTm4's binding with KAP-CDK2 complex. To determine its impact on HTm4's function, HTm4 and C-terminal truncated HTm4 (HTm4-ct) were transfected into K562 cells using Tet-Off regulation expression system. Their influence on cell cycle was observed. The results showed that PMA induced both expansion and differentiation of K562 cells as measured by cell number count and NBT staining respectively. During PMA treatment, G(0)/G(1) cell proportion and HTm4 expression displayed coordinated change, which suggested that HTm4 might drive K562 cells out of cell cycle but was not involved in the quiescence maintenance. Additionally, transfection of HTm4 caused G(0)/G(1) arrest in K562 cells, while transfection of HTm4-ct did not. It is therefore suggested that the C-terminal domain is important for the function of HTm4 in cell cycle regulation.
Deoxythreosyl Phosphonate Nucleosides as Selective Anti-HIV Agents (2005)

Out of a series of eight new phosphonate nucleosides with an l-threose and an l-2-deoxythreose sugar moiety, two new compounds were identified (PMDTA and PMDTT) that showed potent anti-HIV-1 (HIV-2) activity [EC50 = 2.53 microM (PMDTA) and 6.59 microM (PMDTT)], while no cytoxicity was observed at the highest concentration tested [CC50 > 316 microM (PMDTA) and > 343 microM (PMDTT)]. The kinetics of incorporation of PMDTA into DNA (using the diphosphate of PMDTA as substrate and HIV-1 reverse transcriptase as catalyst) was similar to the kinetics observed for dATP, while the diphosphate of PMDTA was a very poor substrate for DNA polymerase alpha. The incorporated PMDTA fits very well in the active site pocket of HIV-1 reverse transcriptase.
Characteristics of human basophil sulfidopeptide leukotriene release: releasability defined as the ability of the basophil to respond to dimeric cross-links. (1986)

Human basophils release approximately 90 pmol of LTC4/micrograms histamine when challenged with anti-IgE antibody, but donor to donor variation produces a 1000-fold range of response. There is little conversion to LTC4 to LTE4 in purified preparations of basophils, but conversion to LTE4 does occur if cell densities are high during incubation. Like histamine release, leukotriene release is calcium and temperature dependent and is complete in 20 min, with a t1/2 of approximately 8 min. The process of desensitization also ablates leukotriene release, but there is a distinct two phase process where leukotriene release is enhanced after 5 min of desensitization, whereas histamine release is inhibited and total ablation of leukotriene release occurs only after 45 min of desensitization. Human basophils respond well to stimulation with covalently cross-linked trimeric IgE myeloma but respond poorly to dimeric IgE. This differential sensitivity to the two forms of cross-linked IgE is most exaggerated in the context of leukotriene release, where dimer is 30-fold less efficacious and 100- to 1000-fold less potent than trimer on some donors' basophils. This dichotomy of response is also observed in antigen-challenged cells, where the bivalent hapten, BPO2, also poorly induces leukotriene release in accord with the fact that it predominantly induces dimeric cross-links of penicillin-specific IgE. Anti-IgE dose-response curves reveal a region of dimeric cross-link dominance that may explain the peculiar differences observed in pharmacologic studies of basophil release induced with antigen vs anti-IgE. In addition, there is a continuum of "releasability," where some donors' basophils display no response (histamine or leukotriene release) to dimeric IgE, and others' basophils are essentially equally responsive to both dimeric and trimeric IgE. This releasability difference manifests itself by conferring increased sensitivity to antigenic challenge in those donors' basophils capable of responding to dimeric cross-links such that these donors' basophils are capable of releasing histamine upon antigen challenge while possessing only 50 molecules of cell surface antigen-specific IgE; other dimer-insensitive donors' basophils require 6 to 10-fold greater IgE densities for equal histamine release.
The new design of an infrared-controlled human-computer interface for the disabled (1999)

This paper reports on the development of an eyeglass- type infrared (IR)-controlled computer interface for the disabled. This system may serve to assist those who suffer from spinal cord injuries or other handicaps to operate a computer. This system is comprised of three major components: 1) an infrared transmitting module, 2) an infrared receiving/signal-processing module, and 3) a main controller, the Intel-8951 microprocessor. The infrared transmitting module utilizes tongue-touch circuitry which is converted to an infrared beam and a low power laser (<0.1 mW) beam. The infrared receiving/signal-processing module, receives the infrared beam and fine tunes the unstable infrared beam into standard pulses which are used as control signals. The main controller is responsible for detecting the input signals from the infrared receiving/signal-processing module and verifying these signals with the mapping table in its memory. After the signal is verified, it is released to control the keys of the computer keyboard and mouse interface. This design concept was mainly based on the idea that the use of an infrared remote module fastened to the eyeglasses could allow the convenient control of the input motion on the keys of a computer keyboard and mouse which are all modified with infrared receiving/signal-processing modules. The system is designed for individuals with spinal cord injuries and disabled in which the subjects' movement are severely restricted. The infrared transmitting module can be easily mounted on eyeglasses or artificial limbs.