gebhart/patrepeval huggingface dataset:
Autonomous Mobile Robot Localization and Navigation Using a Hierarchical Map Representation Primarily Guided by Vision (2014)

While impressive progress has recently been made with autonomous vehicles, both indoors and on streets, autonomous localization and navigation in less constrained and more dynamic environments, such as outdoor pedestrian and bicycle-friendly sites, remains a challenging problem. We describe a new approach that utilizes several visual perception modules—place recognition, landmark recognition, and road lane detection—supplemented by proximity cues from a planar laser range finder for obstacle avoidance. At the core of our system is a new hybrid topological/grid-occupancy map that integrates the outputs from all perceptual modules, despite different latencies and time scales. Our approach allows for real-time performance through a combination of fast but shallow processing modules that update the map's state while slower but more discriminating modules are still computing. We validated our system using a ground vehicle that autonomously traversed three outdoor routes several times, each 400 m or longer, on a university campus. The routes featured different road types, environmental hazards, moving pedestrians, and service vehicles. In total, the robot logged over 10 km of successful recorded experiments, driving within a median of 1.37 m laterally of the center of the road, and localizing within 0.97 m (median) longitudinally of its true location along the route.
Multilayer electroactive ceramic actuators (2002)

A type of electrical component which produces slight (micron level) mechanical movements is introduced. Made from electroactive ceramics and using MLC (multilayer ceramic) fabrication techniques, it offers a new domain of movements with a high degree of precision and absence of magnetic fields. The construction, properties and some potential applications are provided.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Proteomic Analysis of the Eyespot of <i>Chlamydomonas reinhardtii</i> Provides Novel Insights into Its Components and Tactic Movements (2006)

Flagellate green algae have developed a visual system, the eyespot apparatus, which allows the cell to phototax. To further understand the molecular organization of the eyespot apparatus and the phototactic movement that is controlled by light and the circadian clock, a detailed understanding of all components of the eyespot apparatus is needed. We developed a procedure to purify the eyespot apparatus from the green model alga Chlamydomonas reinhardtii. Its proteomic analysis resulted in the identification of 202 different proteins with at least two different peptides (984 in total). These data provide new insights into structural components of the eyespot apparatus, photoreceptors, retina(l)-related proteins, members of putative signaling pathways for phototaxis and chemotaxis, and metabolic pathways within an algal visual system. In addition, we have performed a functional analysis of one of the identified putative components of the phototactic signaling pathway, casein kinase 1 (CK1). CK1 is also present in the flagella and thus is a promising candidate for controlling behavioral responses to light. We demonstrate that silencing CK1 by RNA interference reduces its level in both flagella and eyespot. In addition, we show that silencing of CK1 results in severe disturbances in hatching, flagellum formation, and circadian control of phototaxis.
Monitoring smoking behaviour using a wearable acoustic sensor (2017)

Smoking is a cause of multiple health problems resulting in diseases which can also be fatal. It is well known that smoking has long-term impact on the health of an individual as well. While a number of studies have looked at the impact of smoking on health and its economic impacts, most of these rely on input from smokers in the form of questionnaires and surveys. Long-term monitoring of smoking habits and behaviour is thus not possible because of the lack of means to do so. This paper proposes the use of a wearable device to monitor breathing signals of subjects. It is shown that the acoustic properties of a smoking breath are different from a non-smoking breath. To encapsulate these differences, several features from a breath segment are extracted and used with a simple classifier to automatically identify smoking breaths. The proposed algorithm detected smoking and non-smoking breaths with average accuracy of 66% and 99% respectively.
High‐Performance Organic Solar Cells with Spray‐Coated Hole‐Transport and Active Layers (2010)

Abstract In this study, we report high performance organic solar cells with spray coated hole‐transport and active layers. With optimized ink formulations we are able to deposit films with controlled thickness and very low surface roughness (<10 nm). Specifically we deposit smooth and uniform 40 nm thick films of poly(3,4‐ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) as well as films composed of a mixture of poly(3‐hexyl thiophene) (P3HT) and the C 60 ‐derivative (6,6)‐phenyl C61‐butyric acid methyl ester (PCBM) with thicknesses in the range 200–250 nm. To control film morphology, formation and thickness, the optimized inks incorporate two solvent systems in order to take advantage of surface tension gradients to create Marangoni flows that enhance the coverage of the substrate and reduce the roughness of the film. Notably, we achieve fill factors above 70% and attribute the improvement to an enhanced P3HT crystallization, which upon optimized post‐drying thermal annealing results in a favorable morphology. As a result, we could extend the thickness of the layer to several hundreds of nanometers without noticing a substantial decrease of the transport properties of the layer. By proper understanding of the spreading and drying dynamics of the inks we achieve spray coated devices with power conversion efficiency of 3.75%, with fill factor, short circuit current and open circuit voltage of 70%, 9.8 mA cm −2 and 550 mV, respectively.
Structural and Binding Study of Modified siRNAs with the Argonaute 2 PAZ Domain by NMR Spectroscopy (2011)

By using high-resolution NMR spectroscopy, the structures of a natural short interfering RNA (siRNA) and of several altritol nucleic acid (ANA)-modified siRNAs were determined. The interaction of modified siRNAs with the PAZ domain of the Argonaute 2 protein of Drosophila melanogaster was also studied. The structures show that the modified siRNA duplexes (ANA/RNA) adopt a geometry very similar to the naturally occurring A-type siRNA duplex. All ribose residues, except for the 3' overhang, show 3'-endo conformation. The six-membered altritol sugar in ANA occurs in a chair conformation with the nucleobase in an axial position. In all siRNA duplexes, two overhanging nucleotides at the 3' end enhance the stability of the first neighboring base pair by a stacking interaction. The first overhanging nucleotide has a rather fixed position, whereas the second overhanging nucleotide shows larger flexibility. NMR binding studies of the PAZ domain with ANA-modified siRNAs demonstrate that modifications in the double-stranded region of the antisense strand have some small effects on the binding affinity as compared with the unmodified siRNA. Modification of the 3' overhang with thymidine (dTdT) residues shows a sixfold increase in the binding affinity compared with the unmodified siRNA (relative binding affinity of 17% compared with dTdT-modified overhang), whereas modification of the 3' overhang with ANA largely decreases the binding affinity.
Gene-Expression Analysis and the Basal-Like Breast Cancer Subtype (2007)

Analysis of the patterns of gene expression in breast cancer suggests that it is not a single entity, but is comprised of several biologically distinct subtypes with characteristic molecular profiles. These molecular profiles confirm the clinical impression that estrogen receptor (ER)-negative differs from ER-positive, and expands our understanding by identifying breast cancer subtypes, including the basal-like and human epidermal growth factor receptor (HER)2/ER subtypes within the ER-negative subset, and the luminal A and B subtypes within ER-positive disease. The basal-like subtype is characterized by the low expression levels of the ER-related and the HER2-related group of genes, and therefore is often 'triple negative' on clinical assays for these proteins. This review discusses the molecular profiles of breast cancer with a focus on the clinical characteristics of, and treatment options for, the basal-like subtype.
Finite-difference time-domain simulation of light scattering from single cells (1997)

The finite-difference time-domain (FDTD) technique is used to compute light scattering from biological cells in two dimensions. Results are presented for the computed scattering patterns of cells containing multiple organelles. This method provides considerably more flexibility than Mie theory because of its ability to model inhomogeneous objects such as cells.
Optimisation of Radio Access Network Operation Introducing Self-x Functions: Use Cases, Algorithms, Expected Efficiency Gains (2009)

With the deployment of next generation (4G) mobile radio systems an additional radio access network is established. A variety of different Radio Access Technologies (RATs) will be operated in parallel. In this framework, the Long Term Evolution (LTE) system, specified by 3GPP, will have to co-exist with WiMAX, mobile 2G/3G networks and Wireless Local Area Networks (WLANs). To cope with this increasing diversity and complexity mechanisms for self-optimisation, self-organisation, self-healing, self-configuration (self-x) are essential to guarantee cost efficient and high quality network operation. Within the project E <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> [1] self-x functionalities for different use cases and different elements of a mobile radio access network are developed. Aim of this paper is to give and overview about the interworking of different self-x functionalities and to present three exemplary use cases.
Transcriptional control of the agr‐dependent virulence gene regulator, RNAIII, in Staphylococcus aureus (1996)

Many of the genes coding for extracellular toxins, enzymes and cell-surface proteins in Staphylococcus aureus are regulated by a 510 nt RNA molecule, RNAIII. Expression of the RNAIII gene is positively controlled by the closely linked agr operon, which encodes a multicomponent signal-transduction system, and by an unlinked operon called sar. We have analysed the 120 bp region that separates the RNAIII promoter, P3, from the divergent agr promoter, P2. By transcription analysis, it was shown that P3 can function in trans of the agr operon. A stretch of 53 bp upstream of P3, containing an interrupted repeat of 7 bp, was found to be required for the agr-dependent expression of RNAIII. A single cytoplasmic protein was shown to bind to at least two sites within this regulatory region. The protein, which was absent in extracts from a sarA mutant, was identified as the sarA product by N-terminal amino acid sequencing. A DNA fragment from the P2 region, encompassing an almost identical repeated DNA motif, competed for the same protein. No interaction between the regulatory DNA sequence and any agr-dependent products could be demonstrated. The results of this study suggest that P3 and P2 are controlled by a mechanism involving the binding of the SarA protein to multiple sites within the regulatory regions immediately upstream of each promoter, and the as yet unknown activity of AgrA.
Mono-energetic GeV electrons from ionization in a radially polarized laser beam (2006)

Fields of a radially polarized laser beam developed recently [Y. I. Salamin, Opt. Lett.31, 2619 (2006)] are employed to show that electrons produced by atomic ionization near the focus may be accelerated to GeV energies. Conditions for producing a mono-energetic and well-collimated electron beam are discussed.
Extended Duration of Herpes Simplex Virus DNA in Genital Lesions Detected by the Polymerase Chain Reaction (1991)

To evaluate the utility of the polymerase chain reaction (PCR) for documenting herpes simplex virus (HSV) in persons with reactivated genital lesions viral isolation was compared with a recently developed PCR method. Three women experiencing four episodes of recurrent genital herpes were followed for 10 days per episode with daily examination and duplicate swabs of the lesions, one for HSV culture and one for PCR. HSV type 2 was cultured from three of four episodes and the mean duration of viral isolation from recurrent genital lesions was 2.6 days. PCR detected HSV DNA from lesion swabs during all four episodes, and HSV DNA was positive for an average of 6.8 days. HSV DNA was demonstrated in ulcerative lesions on 15 of 17 days versus 3 of 17 days by viral isolation (P less than .01). HSV PCR became negative when the lesions reepithelialized. These data suggest that PCR is a more sensitive measure of HSV infection than routine viral culture and that PCR detects the presence of HSV at times when culture is negative.
Heavy Oil and Tar Mat Characterization Within a Single Oil Column Utilizing Novel Asphaltene Science (2012)

ABSTRACT A Jurassic oil field in Saudi Arabia is characterized by black oil in the crest, with heavy oil underneath and all underlain by a tar mat at the oil-water contact (OWC). The viscosities in the black oil section of the column are similar throughout the field and are quite manageable from a production standpoint. In contrast, the mobile heavy oil section of the column contains a large, continuous increase in asphaltene content with increasing depth extending to the tar mat. Both the excessive viscosity of the heavy oil and the existence of the tar mat represent major, distinct challenges in oil production. A simple new formalism, the Flory-Huggins-Zuo (FHZ) Equation of State (EoS) incorporating the Yen-Mullins model of asphaltene nanoscience, is shown to account for the asphaltene content variation in the mobile heavy oil section. Detailed analysis of the tar mat shows significant nonmonotonic content of asphaltenes with depth, differing from that of the heavy oil. While the general concept of asphaltene gravitational accumulation to form the tar mat does apply, other complexities preclude simple monotonic behavior. Indeed, within small vertical distances (5 ft) the asphaltene content can decrease by 20% absolute with depth. These complexities likely involve a phase transition when the asphaltene concentration exceeds 35%. Traditional thermodynamic models of heavy oils and asphaltene gradients are known to fail dramatically. Many have ascribed this failure to some sort of chemical variation of asphaltenes with depth; the idea being that if the models fail it must be due to the asphaltenes. Our new simple formalism shows that thermodynamic modeling of heavy oil and asphaltene gradients can be successful. Our simple model demands that the asphaltenes are the same, top to bottom. The analysis of the sulfur chemistry of these asphaltenes by X-ray spectroscopy at the synchrotron at the Argonne National Laboratory shows that there is almost no variation of the sulfur through the hydrocarbon column. Sulfur is one of the most sensitive elements in asphaltenes to demark variation. Likewise, saturates, araomatics, resins and asphaltenes (SARA); measurements also support the application of this new asphaltene formalism. Consequently, the asphaltenes are very similar, and our new FHZ EoS with the Yen-Mullins formalism properly accounts for heavy oil and asphaltene gradients.
A MicroRNA Screen to Identify Modulators of Sensitivity to BCL2 Inhibitor ABT-263 (Navitoclax) (2010)

Evasion of apoptosis is a known feature of cancer cells. One mechanism of deregulating the apoptotic pathway is through overexpression of antiapoptotic BCL2 family members. ABT-263 (navitoclax) is a first-in-class BCL2 family inhibitor that restores the ability of cancer cells to undergo apoptosis. However, many cancer cells are resistant to ABT-263 due to high levels of a BCL2 family member, MCL1, which is not targeted by the drug. MCL1 expression is regulated transcriptionally, translationally, and through proteasome-mediated degradation. Recently, MCL1 expression was shown to be affected by microRNAs (miRNA). To identify miRNAs that modulate the sensitivity of cancer cells to ABT-263, we screened a library of 810 human miRNA mimics in HCT-116 cells in the presence of ABT-263. The screen revealed 19 miRNAs that sensitize HCT-116 cells to ABT-263. Fifteen of these miRNAs were also shown to sensitize CHL1 melanoma cells to the same agent. We further evaluated 12 of the strongest sensitizers in these cell lines. We found that these sensitizers induced apoptosis only in the presence of ABT-263. In addition, whereas all 12 of these miRNAs reduced MCL1 protein expression, only 10 of them targeted MCL1 through direct binding to the 3'-untranslated region of the gene, raising the possibility that other resistance regulators of MCL1 expression may be identified using our method. Finally, because sensitizing miRNA expression is lower in tumors compared with normal tissues, our data can facilitate the design of miRNA replacement therapies to increase sensitivity to BCL2 antagonists.
High Raf-1 kinase activity protects human tumor cells against paclitaxel-induced cytotoxicity. (1998)

Paclitaxel (Taxol) is becoming increasingly important in the treatment of many tumors, although a large proportion of tumors fail to respond to this drug. The identification of the processes that confer cellular paclitaxel resistance could provide potential targets for novel therapies that may help to eliminate paclitaxel-resistant tumors. Recent reports suggest that the Raf-1 protein kinase may have a profound influence on the level of paclitaxel-induced apoptosis. We have critically evaluated the relationship between Raf-1 kinase activity and de novo paclitaxel resistance in early-passage human cervical tumors. In the 12 cell lines studied, Raf-1 kinase activity was inversely correlated (P = 0.0016) with the level of cytotoxicity induced by 60 nM paclitaxel. The relationship between these two parameters seems to be more than an epiphenomenon, because genetic down-regulation of Raf-1 kinase activity led to an approximately 4-fold increase in paclitaxel-induced cytotoxicity. The data from both our transfection studies and those on the 12 unperturbed cell lines are consistent with Raf-1 kinase being a negative determinant of paclitaxel-induced cytotoxicity. Because the cytotoxicity of paclitaxel is primarily attributable to apoptosis, these data suggest that Raf-1 kinase acts to suppress paclitaxel-induced apoptosis. These data suggest that the clinical effectiveness of paclitaxel could be substantially improved by the use of Raf-1 kinase inhibitors, provided that a similar relationship between Raf-1 kinase activity and paclitaxel cytotoxicity exists in the clinic, especially in those tumor sites where paclitaxel is the current treatment of choice e.g., ovarian and breast cancer.
Growth Hormone Alone or Combined with Metoprolol Preserves Cardiac Function After Myocardial Infarction in Rats (2001)

Abstract Background and objective Beta-adrenoreceptor blocking agents are important for the treatment of myocardial infarction (MI). Accumulating evidence also indicates that growth hormone (GH) improves cardiac function after MI in rats. We aimed to investigate the cardiovascular effects of combined treatment in an animal model of MI. Methods MI was induced in rats by ligation of the left coronary artery. Three days after MI, animals were randomly assigned to one of four groups: controls (C) (n-19); GH (n-19) receiving s.c. 2 mg/kg per day rhGH; metoprolol (M) group (n-19) receiving 24 mg/kg per day and combined group (GHM) (n-20) treated with both GH (2 mg/kg per day s.c.) and M (24 mg/kg per day) for 9 days. Transthoracic echocardiography was performed before and after treatment. Results Serum levels of insulin-like growth factor I were significantly elevated in the GH-group but not in the GHM group compared to controls. Left ventricular volumes, cardiac index, systolic blood pressure, were similar in all groups. Percent changes in ejection fraction compared to baseline were; GH (6.1±5.0%) and GHM (6.1±4.2%) vs. C (−12.5±3.0%), P&lt;0.01, M (−7.3±4.2%). The occurrence of aneurysms was not significantly different between the various treatment regimes. Conclusion Treatment with growth hormone alone or in combination with metoprolol preserved left ventricular function after MI.
A New Non-Intrusive Authentication Method Based on the Orientation Sensor for Smartphone Users (2012)

With more advanced features loaded, smart phones nowadays are used not only for telecommunication but also for many emerging applications, such as m-banking. In this paper, we propose a novel non-intrusive authentication mechanism using the information collected from the orientation sensor of the smart phone. This new approach is based on the hypothesis that a user has a unique way to hold and operate his/her smart phone while working on some apps, and such behavioral biometrics can be captured from the readings of the orientation sensor. We design an authentication mechanism that adopts 53 new features transformed from those readings. To validate this hypothesis, we have developed an application to collect user's behavioral biometrics of up-down flicks and left-right flicks from the orientation sensor. The experimental results show that the proposed approach has an equal error rate about 6.85%. We find that the feature subset selected to build an authentication model with satisfactory performance is generally small, varying 3 to 8 for different users. We also find that the feature subsets are significantly different among different users. Finally, we show that the proposed non-intrusive mechanism can be used together with existing intrusive mechanisms, such as password and/or fingerprints, to build a more robust authentication framework for smart phone users.
YÜKSEK RAKIMDA YAŞAYAN BEHÇET HASTALARINDA HEMOTOKRİT YÜKSEKLİĞİNİN VASKÜLER TUTULUMA ETKİSİ (2020)

Amaç: Behçet hastalığı tanısıyla izlenen hastalarda deniz seviyesinden 1890 m de yaşamanın vasküler tutulum ve trombüs ile ilişkisi incelendi.  Materyal ve Metod: Yüksek akımda yaşamakta olan (ortalama 1890 metre) bir eğitim araştırma hastanesinde takip edilen Behçet hastalığı tanısı konulmuş olan hastalar ile ve 890 metrede yaşayan Behçet hastasının vasküler patoloji ve trombüs açısından klinik ve demografik verileri retrospektif olarak karşılaştırıldı.  Bulgular: Her iki grubunda yaş ortalaması ve cinsiyet dağılımı açısından istatiksel olarak anlamlı bir fark yoktu. Vasküler tutulum ve tromboembolik olaylar açısından her iki grupta benzer tutulum gözlendi. Sonuç: Yüksek rakım nedeniyle oluşmuş olan hemotokrit yüksekliği Behçet hastalarında vaskuler tutulum ve trombus için ilave bir risk oluşturmamaktadır.