gebhart/patrepeval huggingface dataset:
Adaptive and Intelligent Web-based Educational Systems (2003)

HAL is a multi-disciplinary open access archive for the deposit and dissemination of sci-entific research documents, whether they are pub-lished or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et a ̀ la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.
Cryopreservation of intact human ovary with its vascular pedicle (2006)

Cryoperfusion and cryopreservation of entire human ovary can be achieved with the maintenance of excellent viability of the superficial and the deeper tissues using a slow-freezing protocol. Cryopreservation injury is associated neither with significant alteration in the expression pattern of Bcl-2 and p53 proteins in the ovarian tissues nor with significant follicular damage.
Quantifying the financial impact of it security breaches on business processes (2014)

With the rise of the number of security breaches affecting organizations nowadays, it has become crucial for companies to accurately measure the costs of such incidents and mitigate them in order quantify their risk exposure and direct IT security investments. However, with the absence of standardized cost calculation methods, the task of quantifying the internal costs of security breaches as well as the costs of managing them is one of the difficulties of security risk analysis. Due to the fact that companies consider the time spent by employees during the reparation process of an affected IT resource as idle, overestimations of the costs of security breaches and lost productivity, represented by the system downtime from employees' perception, occur. For these reasons, this study suggests a new approach for measuring the negative economic impact associated with such security attack events. This study proposes a method which assumes that alternative tasks that do not rely on the affected IT resource are performed; hence, the employees' time is not considered as completely idle and consequently the total costs decrease. Early results have shown that our suggested method renders smaller total costs than companies' method when calculating the costs of information security breaches due to the decrease in the idle time; whereas cost components due to delayed work products are typically not captured at all. Our results have also shown how recovery procedures, in terms of dissolving of work task queues, are performed in case of information security breaches.
Team Work Matters: Dual Inhibition Puts Non-Hodgkin Lymphoma Under Siege (2014)

Inhibitors of PI3K/mTOR and histone deacetylases (HDAC) are effective in non-Hodgkin lymphoma (NHL). However, clinical resistance eventually ensues and combinatory therapies are sought to prevent it. Preclinical evaluation of dual PI3K/mTOR and HDAC inhibition is synergistic against NHL, paving the way for bench-to-bedside translation.
A generic system for directory pagination (2002)

A description is presented of DX (Directory Expert), which is a Lisp-based system that merges gridding specifications with page layout and graphic programs to create the NYNEX Yellow Pages telephone directory. This system uses a custom-built inference engine that drives the knowledge components and also uses domain-specific knowledge to optimize the page layout process. As pages are generated, the system tests each configuration based on NYNEX gridding specifications. The resulting pages are automatically evaluated so that the gridders can concentrate on correcting the difficult exceptions to the gridding specifications.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Detecting corrupted intra macroblocks in H.263 video (2004)

Corrupted low frequency data of intra coded macroblocks can significantly degrade quality of video in error prone wireless networks. Therefore, a new method for detecting the corrupted blocks is presented. The method exploits temporal smoothness of video by computing the absolute difference between subsequent video frames. A threshold function is used to highlight the block differences, and a heuristic is developed to detect the corrupted blocks. The proposed method is evaluated with our wireless video simulator, which shows that the method substantially improves image quality of video conferencing sequences in presence of transmission errors. In addition, the method is compared to average intersample difference across the block boundaries (AIDB) algorithm whose performance is shown to be more sensitive to selection of correct threshold values than the proposed method.
Uniaxial magnetic FeC thin films sputtered onto polymer substrates (1995)

Thin films of FeC were deposited onto a polymer substrate by reactive DC magnetron sputtering, using an argon and hydrocarbon gas mixture. The polymer web is wound by a roll coater, and an individual thin film with a constant thickness is piled up by increasing a number of passes UP to a desired thickness. Uniaxial films with Hk=4000 A/m and low dispersion were obtained. The coercive force was a function of thickness; it was Hc=8 A/m for films 0.8 /spl mu/m thick. The easy axis of the uniaxial anisotropy was along the direction transverse to the rolling direction of the polymer web. The origin of the uniaxial anisotropy is the anisotropic thermal shrinkage of the polymer web is discussed by a model.
Boosting Ethernet using Regular Switching Hubs (2006)

Ethernet is the most pervasive communication technology in use today. It is a standard for connecting computers to form a local area network and provides a common method for the exchange of data. In this paper, we propose a Linux solution, Bonding-Plus, to support real-time control and boost bandwidth using multiple network interface cards connected to regular switching hubs in an Ethernet environment. BondingPlus schedules packets in the data link layer without modification to the hardware or operating system in the host machine. Real-time packets can be transmitted via one or several dedicated bonding Ethernet interfaces, and there is no competition with low priority packets. Transmission delay and network jitter for real-time packets can be dramatically reduced. Furthermore, bandwidth can be increased in proportion to the number of bonding Ethernet interfaces under both TCP and UDP transmission. Various types of systems, such as clustering and parallel systems, can be enhanced at minimal hardware cost.
Calcium-sensing receptor gene polymorphism Arg990Gly and its possible effect on response to cinacalcet HCl (2005)

Cinacalcet, a novel calcimimetic compound, is effective in reducing parathyroid hormone (PTH) levels in approximately 70% of patients with secondary hyperparathyroidism. However, interindividual variations in the dose required to achieve the treatment goal have been noted in clinical studies. Our investigation examined the genetic polymorphisms of the calcium-sensing receptor (CaSR) gene as one possible cause of the different responses to cinacalcet. We report data on seven end-stage renal failure patients who were treated with regular haemodialysis and who participated in clinical trials of cinacalcet. All patients had secondary hyperparathyroidism with baseline intact PTH (iPTH) levels greater than 600 pg/ml. Three patients were male and four female with a mean+/-SD age of 60+/-12 years. DNA was extracted from peripheral lymphocytes. An area in exon 7 of the CaSR gene was amplified by the polymerase chain reaction and sequenced. Mean+/-SD baseline iPTH was 1086+/-189 pg/ml. The five patients without Arg990Gly demonstrated a 29.7+/-4.0% (+/-SEM) reduction in iPTH from individual baseline. One patient was found to be homozygous for the Arg990Gly polymorphism and another was heterozygous for both arginine and glycine alleles. The homozygous patient showed a significantly higher sensitivity to cinacalcet compared to the other patients (P=0.003) with a 76.3+/-7.7% reduction in iPTH from baseline. No polymorphisms were noted in codons 986 or 1011. This preliminary study points to the possibility that patients homozygous for glycine at the 990 position in exon 7 of the CaSR may be more sensitive to the calcimimetic drug cinacalcet compared to those who are homozygous for arginine at that location.
Graphitic Electrical Contacts to Metallic Single-Walled Carbon Nanotubes Using Pt Electrodes (2009)

We investigate electronic devices consisting of individual, metallic, single-walled carbon nanotubes contacted by Pt electrodes in a field effect transistor configuration, focusing on improvements to the metal-nanotube contact resistance as the devices are annealed in inert environments including ultrahigh vacuum. At moderate temperatures (T < 880 K), thermal processing results in high resistance contacts with thermally activated barriers. Higher temperatures (T > 880 K) achieve nearly transparent contacts. In the latter case, analytical surface measurements reveal the catalytic decomposition of hydrocarbons into graphene layers on the Pt surface, suggesting that improved electronic behavior is primarily due to the formation of an all-carbon nanotube-graphite interface rather than to the improvement of the nanotube-Pt one.
The human circadian system in normal and disordered sleep. (2005)

The human circadian system regulates rhythmicity in the human body and establishes normal sleep and wake phases. The suprachiasmatic nuclei (SCN), located in the hypothalamus above the optic chiasm, make up the human pacemaker known as the circadian or biological clock, but other essential parts of the circadian system include the pineal gland, retina, and retinohypothalamic tract. The importance of light in resetting the intrinsic human circadian cycle, the intrinsic period of which is slightly longer than 24 hours, ensures that the human cycle will stay entrained to the earth's 24-hour daily cycle. Within the SCN neurons, circadian rhythmicity is generated by the regular transcription of proteins. Since the circadian system is the foundation of the sleep-wake cycle, disorders and abnormalities in sleep are often connected with disorders or abnormalities in the circadian system. Circadian rhythm sleep disorders, such as jet lag syndrome and shift work sleep disorder, are those specifically attributed to dysfunctions or insufficiencies in the circadian system. Taking into consideration the preeminence of the circadian clock in timing sleep, it is likely that other sleep disorders, such as insomnia, are also linked to circadian system abnormalities.
Effect of culture conditions on artificial activation of porcine oocytes matured in vitro (1996)

The effects of culture media used and culture period for in vitro maturation of porcine oocytes on their subsequent response to chemical and electrical activation, were investigated. Activated oocytes were identified by the presence of a pronucleus(ei) or cleavage. Porcine oocytes were cultured for 24, 30, 36, 42 and 48 h in TCM199 with Earle's salts (199) supplemented with 10% fetal calf serum (199-FCS) before electrical stimulation. Although few oocytes were activated after 24 h and 30 h of culture (5.4% and 6.1% respectively), the percentage of activated oocytes increased significantly to 93.2% after 42 h in culture (P &lt; 0.05); however, when the culture period was extended to 48 h, there was a significant decrease to 56.7% (P &lt; 0.05). Oocytes were also cultured in four types of media: (1) 199-FCS; (2) 199 supplemented with 5 mg mL-1 bovine serum albumin (199-BSA); (3) Kreb's-Ringer bicarbonate solution supplemented with 10% FCS (KRB-FCS); and (4) KRB supplemented with BSA (KRB-BSA). After 42 h of culture in each medium, the oocytes were electrically activated. Although rates of maturation of oocytes cultured in the four media were similar (74.0-80.8%), all oocytes except those cultured in 199-FCS failed to be activated. In addition, oocytes were cultured for 36, 42 and 48 h in 199-FCS and then stimulated by treatment with ethanol. Significantly fewer oocytes were activated in the chemically-treated group than in the electrically-treated group. These results indicate that culture conditions used for the culture of porcine oocytes in vitro are important with respect to their subsequent response to artificial activation.
Modification of optical properties of metal island films by electric field-assisted dissolution of clusters (2008)

Metal island films show unique optical properties owing to the local surface plasmon resonance of islands free electrons. In the present study, the electric field assisted dissolution of clusters in metal island films is reported. Island films of Au, Ag, and Cu are deposited under different conditions by thermal evaporation and coated with thin dielectric layers. The samples are treated with the simultaneous application of an intense electric field and temperature, leading to the sample partial or total bleaching due to the dissolution of metal clusters in the films. Owing the facility of production of metal island films and the inexpensive technical requirements of the dissolution process, this approach suggests a novel path for the production of low-cost photonic structures.
Down‐Regulatory Effect of <i>Mycobacterium leprae</i> Cell Wall Lipids on Phagocytosis, Oxidative Respiratory Burst and Tumour Cell Killing by Mouse Bone Marrow Derived Macrophages (1997)

The authors have previously demonstrated that lipids from Mycobacterium leprae cell walls inhibit macrophage functions and are endowed with anti‐inflammatory properties in vivo . To investigate these observations further, the authors describe here the influence of dead M. leprae or of the lipids extracted from the cell wall of the mycobacterium, enclosed in liposomes, on the phagocytic, oxidative respiratory burst and tumouricidal ability of bone marrow derived macrophages in vitro . Dead M. leprae or its cell wall lipids abrogated the oxidative respiratory burst and phagocytic ability of mouse bone marrow derived macrophages. A dose‐dependent inhibitory effect of the bacterial lipid extract on tumour cell killing by lipopolysaccharide (LPS)‐activated bone marrow derived macrophages was demonstrated. However, when delipidated M. leprae was added to cultures of bone marrow derived macrophages, immune phagocytosis and superoxide production was up‐regulated. Mycobacterium leprae or its lipids did not appear to be toxic to those cells assayed by the MTT (methyl thiazol tetrazolium) test. These data, added to our preceding observations, support the hypothesis that the down‐regulatory activity of M. leprae wall lipids on macrophage function might be one of the evasive mechanisms of the bacterium to enable it to perpetuate itself in the host tissues.
Fluorine implantation for effective work function control in p-type metal-oxide-semiconductor high-k metal gate stacks (2011)

The instability of the p-type metal effective work function of high-k/metal gate metal-oxide-semiconductor stacks after high temperature treatment results in device threshold voltage shifts and is one of the big challenges for the gate-first integration of high-k dielectrics in the future complementary metal-oxide semiconductor process flow. The exact cause of this instability is a subject of intense debate. In this article, it is shown that by implanting the gate stack with a fluorine dose of 1015 cm−2, it is possible to achieve an appropriate silicon valence band-edge effective work function of 5.1 eV for p-type metal-oxide-semiconductor devices. It is also shown that the fluorine doping can be accomplished not only with F+, but also with BF2+ ions. The influence of the implantation energy on the obtained effective work function is demonstrated and discussed. The origin of the induced shift is also discussed. Leakage current measurements show that the leakage properties of high-k stacks are not worsened by F implantation, while the implantation of BF2 slightly affects the leakage currents.
Integrating information retrieval and domain specific approaches for browsing and retrieval in object-oriented class libraries (1991)

Article Integrating information retrieval and domain specific approaches for browsing and retrieval in object-oriented class libraries Share on Authors: Richard Helm I.B.M. Thomas J. Watson Research Center, P.O. Box 704, Yorktown Heights, NY I.B.M. Thomas J. Watson Research Center, P.O. Box 704, Yorktown Heights, NYView Profile , Yoëlle S. Maarek I.B.M. Thomas J. Watson Research Center, P.O. Box 704, Yorktown Heights, NY I.B.M. Thomas J. Watson Research Center, P.O. Box 704, Yorktown Heights, NYView Profile Authors Info & Claims OOPSLA '91: Conference proceedings on Object-oriented programming systems, languages, and applicationsNovember 1991 Pages 47–61https://doi.org/10.1145/117954.117958Online:01 November 1991Publication History 40citation526DownloadsMetricsTotal Citations40Total Downloads526Last 12 Months6Last 6 weeks2 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Islets of Langerhans (2014)

This book contains critical background information, and recent advances made in essentially all areas of islet research. It is a major reference book, the first of its kind, for islet researchers, and diabetes researchers. Anybody, including the experts, and the beginners, interested in the study of islet physiology, and diabetes, will find this book extremely useful. The book is robust in its breadth: it deals with anatomy, histology, ultra-structure, evolution and comparative anatomy, imaging, developmental biology, programming, apoptosis, mitochondrial function, metabolism, cellular signaling, electrophysiology, oscillation of hormone secretion, islets of model animals, immunology, proteomics, regenerative medicine, clinical advances, and islet transplantation. Individual chapters contributed by a large number of experts and enthusiasts, not only provide a balanced view of the recent advances made in the respective fields, but also provide directions and thoughts for future research. Thanks to vivid and colorful illustrations, tables and sketches, the book as a whole, and the individual chapters make reading a pleasant experience. If you are interested in diabetes research, you will love to have a personal copy of this book.
Physicochemical Characterization of Thermoresponsive Poly(<i>N</i>-isopropylacrylamide)−poly(ethylene imine) Graft Copolymers (2008)

Synthetic polycations have shown promise as gene delivery vehicles but suffer from an unacceptable toxicity and low transfection efficiency. Novel architectures are being explored to increase transfection efficiency, including copolymers with a thermoresponsive character. The physicochemical characterization of a family of copolymers comprising a core of the cationic polymer poly(ethylene imine) (PEI) with differing thermoresponsive poly( N-isopropylacrylamide) (PNIPAM) grafts has been carried out using pulsed-gradient spin-echo NMR (PGSE-NMR) and small-angle neutron scattering (SANS). For the copolymers that have longer chain PNIPAM grafts, there is clear evidence of the collapse of the grafts with increasing temperature and the associated emergence of an attractive interpolymer interaction. These facets depend on the number of PNIPAM grafts attached to the PEI core. While a collapse in the smaller PNIPAM grafts is observed for the third polymer, there is no appearance of the interpolymer attractive interaction. These observations provide further insight into the association behavior of these copolymers, which is fundamental to developing a full understanding of how they interact with nucleic acids. Furthermore, the differing behaviors of the three copolymers over temperatures in which the PNIPAM blocks undergo coil-to-globule transitions is indicative of changes in the presentation of charged-core and hydrophobic chain components, which are key factors affecting nucleic acid binding and, ultimately, cell transfection ability.
Plans for Next-Gen Chips Imperiled (2007)

In chip industry, a technique called extreme ultraviolet (EUV) photolithography would be ready to start churning out cutting-edge logic chips. Today's technology uses light with a wavelength of 193 nanometers to produce chips with key parts, or features, that measure just 65 nm.
Activity-based probes for rhomboid proteases discovered in a mass spectrometry-based assay (2013)

Rhomboid proteases are evolutionary conserved intramembrane serine proteases. Because of their emerging role in many important biological pathways, rhomboids are potential drug targets. Unfortunately, few chemical tools are available for their study. Here, we describe a mass spectrometry-based assay to measure rhomboid substrate cleavage and inhibition. We have identified isocoumarin inhibitors and developed activity-based probes for rhomboid proteases. The probes can distinguish between active and inactive rhomboids due to covalent, reversible binding of the active-site serine and stable modification of a histidine residue. Finally, the structure of an isocoumarin-based inhibitor with Escherichia coli rhomboid GlpG uncovers an unusual mode of binding at the active site and suggests that the interactions between the 3-substituent on the isocoumarin inhibitor and hydrophobic residues on the protease reflect S' subsite binding. Overall, these probes represent valuable tools for rhomboid study, and the structural insights may facilitate future inhibitor design.
Ambulatory ST segment monitoring in the assessment of patients following PTCA (1989)

In this article we discuss the place of ambulatory ST-segment monitoring in the investigation of the patient following coronary angioplasty. Particular attention is focused on the relationship between the results of exercise testing (the standard technique in the evaluation of the post-angioplasty patient) and ambulatory ST-segment monitoring, in order to assess whether ST-segment monitoring might contribute further information in the identification of residual or recurrent ischaemia.
Anti-endothelial cell antibodies: detection and characterization in sera from patients with autoimmune hypoparathyroidism. (1988)

In a previous report, we described antibodies in autoimmune hypoparathyroidism (AHP) that are cytotoxic for cultured bovine parathyroid cells. In the present study, we show that sera from six AHP patients, but not from 26 patients with other autoimmune diseases or from 7 healthy subjects, react with bovine endothelial cells in culture (by flow cytometry and fluorescence microscopy) and in tissue sections (by immunohistology). We found uniformly that the immunoglobulin class reacting is IgM. Adsorption experiments showed that the antigenic determinants reacting with AHP sera were similar on bovine cultured endothelial cell membranes and in tissue sections of bovine parathyroid glands. The AHP sera also reacted with endothelial cells cultured from bovine adrenal medulla and pulmonary artery. Immunoblot analysis showed antibody binding to two major bands of 200 and 130 kDa solubilized from the membrane fraction of bovine parathyroid endothelial cells. Only one AHP serum consistently recognized endothelium-related structures on frozen sections of three different human parathyroid adenomas; two other sera reacted with one adenoma each; and three did not react with human adenomas. This indicates that human material is less suitable than bovine in detecting endothelium-related immune phenomena in AHP sera. The anti-endothelium IgM antibodies appear to be disease-specific but are not organ- or species-specific. The identification of endothelial cells as the target for antibodies in AHP raises the possibility that the endothelium subserves an important local function for endocrine epithelium.