gebhart/patrepeval huggingface dataset:
Full-Time Supervision based Bidirectional RNN for Factoid Question Answering (2016)

Recently, bidirectional recurrent neural network (BRNN) has been widely used for question answering (QA) tasks with promising performance. However, most existing BRNN models extract the information of questions and answers by directly using a pooling operation to generate the representation for loss or similarity calculation. Hence, these existing models don't put supervision (loss or similarity calculation) at every time step, which will lose some useful information. In this paper, we propose a novel BRNN model called full-time supervision based BRNN (FTS-BRNN), which can put supervision at every time step. Experiments on the factoid QA task show that our FTS-BRNN can outperform other baselines to achieve the state-of-the-art accuracy.
Structure-Based Optimization of Multifunctional Agonists for Opioid and Neuropeptide FF Receptors with Potent Nontolerance Forming Analgesic Activities (2016)

The opioid and neuropeptide FF pharmacophore-containing chimeric peptide 0 (BN-9) was recently developed and produced potent nontolerance forming analgesia. In this study, 11 analogues of 0 were designed and synthesized. An in vitro cAMP assay demonstrated that these analogues behaved as multifunctional agonists at both opioid and NPFF receptors. In mouse tail-flick test, most of the analogues produced potent nontolerance forming antinociception. Notably, 11 (DN-9) was 33-fold more potent than 0 at analgesic effects, which was mediated by μ- and κ-opioid receptors. In addition, 11 also produced powerful analgesic effects in the formalin pain and CFA-induced chronic inflammatory pain models. Strikingly, following its repeated administration for 6 days, 11 did not produce antinociceptive tolerance in the tail-flick test and CFA-induced pain model. The present work indicates that it is reasonable to design multifunctional peptide ligands for opioid and NPFF receptors in a single molecule producing effective nontolerance forming antinociception.
Transgenic Progeny Inherit Tissue-Specific Expression of Rat Elastase I Genes (1986)

Six different lines of transgenic mice bearing rat elastase I genes stably inherit both the high-level pancreatic expression and low-level nonpancreatic expression characteristic of each original founding mouse. The high pancreatic expression of the introduced rat genes is transcriptionally determined. In response to high rat elastase I mRNA content in the pancreas, rat elastase I protein is synthesized and secreted at high levels. The stable inheritance of expression of the foreign rat elastase I genes in transgenic mice allows the development of animal lines that synthesize and secrete high levels of foreign protein by the pancreas.
Molecular basis of spontaneous regression of neuroblastoma: role of neurotrophic signals and genetic abnormalities. (1998)

Neuroblastoma is one of the most common pediatric solid tumors originating from the sympathoadrenal lineage of the neural crest. The tumors found in infants very frequently regress spontaneously by differentiating and/or undergoing programmed cell death, while those in children over one year of age are very aggressive and eventually kill the patients. The recent advances in neuroblastoma research have revealed that the neurotrophin signals, especially those through nerve growth factor and its receptor, TrkA, play an important role in regulating the regression of neuroblastoma. The genetic abnormalities such as allelic loss of the distal region of chromosome 1p, gain of chromosome 17q21-q25, and MYCN amplification, all of which are associated with the tumor aggressiveness, inhibit the regression of neuroblastoma. In the regressing tumor cells, caspases are induced and surviving, which is mapped to 17q25 and is overexpressed in the advanced stage tumors, is down-regulated. Thus, the molecular mechanism of spontaneous regression of neuroblastoma is now being unveiled. However, many more questions including the developmental machinery to trigger regression still remain to be clarified.
Solution structures of nisin A and its two major degradation products determined by n.m.r (1992)

The conformations of nisin and two major degradation products, nisin-(1-32)-peptide (nisin1-32) and des-delta Ala5-nisin1-32 (where delta Ala is alpha beta-didehydroalanine), in aqueous solution have been determined from n.m.r. data. Sequential assignments of the peptides using correlation spectroscopy ('COSY'), homonuclear Hartmann-Hahn spectroscopy ('HOHAHA'), nuclear Overhauser enhancement spectroscopy (NOESY), relayed NOESY and rotating-frame nuclear Overhauser spectroscopy (ROESY) experiments are presented, including stereospecific assignments of beta-methylene protons of the lanthionine residues. ROESY experiments are also used to detect flexible regions in the polypeptide chain. A dynamic-stimulated-annealing approach is used for structural determination. It can be concluded that all these peptides are flexible in aqueous solution, with no experimental evidence of preferred overall conformations; the only defined conformational features are imposed by the presence of the lanthionine residues. Low-temperature studies also reveal that des-delta Ala5-nisin1-32 adopts conformations similar to those when the ring is intact, suggesting that the loss of activity of this degradation product is due to the absence of the delta Ala5 residue rather than to the conformational consequences of ring-opening.
Alveolar Macrophage–mediated Killing of <i>Pneumocystis carinii</i> f. sp. <i>muris</i> Involves Molecular Recognition by the Dectin-1 β-Glucan Receptor (2003)

Innate immune mechanisms against Pneumocystis carinii, a frequent cause of pneumonia in immunocompromised individuals, are not well understood. Using both real time polymerase chain reaction as a measure of organism viability and fluorescent deconvolution microscopy, we show that nonopsonic phagocytosis of P. carinii by alveolar macrophages is mediated by the Dectin-1 beta-glucan receptor and that the subsequent generation of hydrogen peroxide is involved in alveolar macrophage-mediated killing of P. carinii. The macrophage Dectin-1 beta-glucan receptor colocalized with the P. carinii cyst wall. However, blockage of Dectin-1 with high concentrations of anti-Dectin-1 antibody inhibited binding and concomitant killing of P. carinii by alveolar macrophages. Furthermore, RAW 264.7 macrophages overexpressing Dectin-1 bound P. carinii at a higher level than control RAW cells. In the presence of Dectin-1 blockage, killing of opsonized P. carinii could be restored through FcgammaRII/III receptors. Opsonized P. carinii could also be efficiently killed in the presence of FcgammaRII/III receptor blockage through Dectin-1-mediated phagocytosis. We further show that Dectin-1 is required for P. carinii-induced macrophage inflammatory protein 2 production by alveolar macrophages. Taken together, these results show that nonopsonic phagocytosis and subsequent killing of P. carinii by alveolar macrophages is dependent upon recognition by the Dectin-1 beta-glucan receptor.
The Mechanical Properties of Wrought Phosphor Bronze Alloys (1956)

This paper shows the effect of cold-working on the mechanical properties of a series of eight phosphor bronze alloys in the form of cold-rolled strip. The tin content of these alloys varied from 0.5 to 10 per cent. Each material was furnished in two conditions with different ready-to-finish grain sizes. Electrolytic tough pitch copper strip similarly treated is included to provide a base for evaluating the effectiveness of the tin additions. The mechanical properties—including tensile strength, proportional limit, yield strength at both 0.01 and 0.2 per cent offset, modulus of elasticity, elongation, bending fatigue characteristics at lifetimes ranging from 100,000 to 100,000,000 cycles, and the Rockwell hardness (B and 30T values)—are reported for six different tempers of each of the 18 materials. The tempers studied include annealed, half-hard, hard, extra-hard, spring and extra-spring. Data are also included on the 3, the 4, and the 5 per cent tin alloys to show the effect of a higher phosphorus content. The effect of a larger ready-to-finish grain size on the mechanical properties of the high phosphorus, 4 per cent tin alloy is discussed.
Physical Description of Single-Screw Extrusion (2019)

No AccessExtrusion of PolymersOct 2019Physical Description of Single-Screw ExtrusionChan I. ChungChan I. Chunghttps://doi.org/10.3139/9781569907382.002SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2019Pages: 17-61Print ISBN: 978-1-56990-609-5eISBN: 978-1-56990-738-2 Copyright & PermissionsCopyright by Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
AtVPS29, a Putative Component of a Retromer Complex, is Required for the Efficient Sorting of Seed Storage Proteins (2006)

Seed storage proteins are synthesized on rough endoplasmic reticulum (ER) as larger precursors and are sorted to protein storage vacuoles, where they are converted into the mature forms. We report here an Arabidopsis mutant, maigo 1 ( mag1 ), which abnormally accumulates the precursors of two major storage proteins, 12S globulin and 2S albumin, in dry seeds. Electron microscopy revealed that mag1 seeds mis-sort storage proteins by secreting them from cells. mag1 seeds have smaller protein storage vacuoles in the seeds than do wild-type seeds. The MAG1 gene encodes a homolog of the yeast ( Saccharomyces cerevisiae ) protein VPS29. VPS29 is a component of a retromer complex for recycling a vacuolar sorting receptor VPS10 from the pre-vacuolar compartment to the Golgi complex. Our findings suggest that MAG1/AtVPS29 protein is involved in recycling a plant receptor for the efficient sorting of seed storage proteins. The mag1 mutant exhibits a dwarf phenotype. A plant retromer complex plays a significant role in plant growth and development.
Digital drug delivery: on–off ultrasound controlled antibiotic release from coated matrices with negligible background leaching (2014)

Hydrogels, such as crosslinked poly(2-hydroxyethyl methacrylate) (pHEMA) have been used extensively in controlled release drug delivery systems. Our previous work demonstrated an ultrasound (US)-responsive system based on pHEMA coated with a self-assembled multilayer of C12-C18 methylene chains. The resulting coating was predominantly crystalline and relatively impermeable, forming an US-activated switch that controlled drug release on-demand, and kept the drug within the matrix in the absence of US. The device, as developed did, however, show a low background drug-leaching rate independent of US irradiation. For some applications, it is desirable to have very low or zero background release rates. This was achieved here by a combination of new processing steps, and by copolymerizing HEMA with a relatively hydrophobic monomer, hydroxypropyl methacrylate (HPMA). These advances produced systems with undetectable ciprofloxacin background release rates that are capable of US-facilitated drug release - up to 14-fold increases relative to controls both before and after US exposure. In addition, these observations are consistent with the hypothesis that US-mediated disorganization of the coating allows a transient flux of water into the matrix where its interaction with bound and dissolved drug facilitates its movement both within and out of the matrix.
Nickel-Mediated Conjugate Addition. Elaboration of Calcitriol from Ergocalciferol (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNickel-Mediated Conjugate Addition. Elaboration of Calcitriol from ErgocalciferolPercy S. Manchand, George P. Yiannikouros, Peter S. Belica, and Pradeep MadanCite this: J. Org. Chem. 1995, 60, 20, 6574–6581Publication Date (Print):October 1, 1995Publication History Published online1 May 2002Published inissue 1 October 1995https://pubs.acs.org/doi/10.1021/jo00125a051https://doi.org/10.1021/jo00125a051research-articleACS PublicationsRequest reuse permissionsArticle Views1060Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ATLANTIDES: an architecture for alert verification in network intrusion detection systems (2007)

We present an architecture 1 designed for alert verification (i.e., to reduce false positives) in network\nintrusion-detection systems. Our technique is based on a systematic (and automatic) anomaly-based\nanalysis of the system output, which provides useful context information regarding the network\nservices. The false positives raised by the NIDS analyzing the incoming traffic (which can be either\nsignature- or anomaly-based) are reduced by correlating them with the output anomalies. We designed our architecture for TCP-based network services which have a client/server architecture (such as HTTP). Benchmarks show a substantial reduction of false positives between 50% and 100%.\n1This research is supported by the research program Sentinels\n(http://www.sentinels.nl). The work of the second author\nwas partially funded by the IST FP6 GridTrust project,\ncontract No. 033827. Part of this work was carried out during\nthe third author’s stay at the University of Trento, supported\nby the GU-IST project Serenity.
A New Technique for Heavy Oil Recovery Based on Electromagnetic Heating: Pilot Scale Experimental Validation (2013)

Due to the depletion and the increasingly high cost of conventional light oil resources, in the future unconventional oils are due to become one of the major hydrocarbon source. In order to extract crude oil from these resources, a sufficiently low viscosity must be achieved, for instance through temperature increase. Electromagnetic irradiation can be a suitable method for in situ heating of reservoirs: major problems connected with this technique are the extremely high temperatures that can be reached at the well and the strong dependence on local variations of reservoir material properties. These problems can be solved to a large extent by inserting around the well, in proximity of the radiating element, a tight shell made of low-loss dielectric materials. The experimental work described in this paper aims to study the phenomena connected with the electromagnetic heating of an oil sand reservoir up to 150 °C, in order to assess the effectiveness of the novel tight shell conceptual design. Over 2000 kg of oil sand were inserted in a steel box and irradiated at 2.45 GHz frequency. The radiating element is a dipolar antenna inserted in the center of the oil sand volume. The temperature in the oil sand was recorded throughout the test in several points, in order to estimate temperature profiles along the distance from the antenna. Results confirm that electromagnetic irradiation is capable of heating both wet and dry oil sands, since the temperature in the sample rises well above connate water boiling temperature. Water vaporization significantly impacts on temperature profiles and contributes to limit the temperature near the well. An even larger positive effect on energy distribution and heating homogeneity is assured by the low-loss shell realized around the antenna, that is extremely efficient in lowering the temperature in this critical zone.
Gene regulation of neurokinin B and its receptor NK3 in late pregnancy and pre-eclampsia (2006)

Elevated circulating levels of the tachykinin, neurokinin B (NKB), have been observed in women with pre-eclampsia during the third trimester of pregnancy. Currently, the molecular mechanisms responsible for these increased levels remain unknown. To understand the molecular regulation, we have compared the differences in gene expression of the tachykinins and their receptors in control and pre-eclamptic placentae and the responses of the TAC3 gene encoding NKB to proposed physiological triggers of pre-eclampsia including hypoxia and oxidative stress using real-time quantitative PCR. We have determined the placenta to be the main site of TAC3 expression with levels 2.6-fold higher than the brain. TAC3 expression was found to be significantly higher in pre-eclamptic placenta (1.7-fold, P < 0.05) than in normal controls. No evidence was found that hypoxia and oxidative stress were responsible for increases in TAC3 expression. In rat placenta, a longitudinal study in normal late pregnancy was associated with a significant down-regulation of the NKB/NK3 ligand-receptor pair (P < 0.05). The present data suggest that the increased placental expression of TAC3 is part of the mechanism leading to the increased circulating levels of NKB in pre-eclampsia.
Asthma: personalized and precision medicine (2017)

This step-by-step transition would bring to a better approach to severe asthmatic patients as the personalization of their therapeutic strategy would bring to a better patient selection, a more precise endotype-driven treatment, and hopefully to better results in terms of reduction of exacerbation rates, symptoms, pulmonary function and quality of life.
Upper Limit to Magnetism in<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:msub><mml:mi>LaAlO</mml:mi><mml:mn>3</mml:mn></mml:msub><mml:mo>/</mml:mo><mml:msub><mml:mi>SrTiO</mml:mi><mml:mn>3</mml:mn></mml:msub></mml:math>Heterostructures (2011)

Using polarized neutron reflectometry we measured the neutron spin-dependent reflectivity from four LaAlO(3)/SrTiO(3) superlattices. Our results imply that the upper limit for the magnetization averaged over the lateral dimensions of the sample induced by an 11 T magnetic field at 1.7 K is less than 2 G. SQUID magnetometry of the neutron superlattice samples sporadically finds an enhanced moment, possibly due to experimental artifacts. These observations set important restrictions on theories which imply a strongly enhanced magnetism at the interface between LaAlO(3) and SrTiO(3).
Changes in Clinical Research in Anaesthesia and Intensive Care from 1974–2004 (2006)

The purpose was to identify how the quality of anaesthesia research has improved from articles published in Anaesthesia and Intensive Care over 25 years. Original papers were included during the periods 1974-1978 and 2000-2004. Each article was classified according to principal research designs and the two five-year periods were compared. All interventional trials were evaluated according to the following a priori criteria: author number; ethics approval; informed consent; competing financial interest; eligibility criteria; sample size calculation; method of randomization; patients accounted for; blind assessment of outcome; adverse outcomes; statistical method stated; type I error; type II error; and anaesthetic department of origin. Comparisons of above criteria were made between the two groups using chi-square test or Fischer's exact test. Two-hundred-and-ninety-two articles were reviewed in 1974-1978 and 529 articles were reviewed in 2000-2004. Animal/laboratory articles decreased from 17.47% to 12.28% (P=0.05). Review articles decreased from 34.35% to 10.4% (P<0.0001). Descriptive trials increased from 28.4% to 52.72% (P<0.0001). Interventional trials increased from 18.84% to 22.31% (P=0.269). Uncontrolled clinical trials decreased from 27.27% to 12.71%, non-randomized controlled trials decreased from 50.91% to 7.63%, and randomized controlled trials increased from 21.82% to 79.66% (P<0.0001). All interventional trials criteria improved and were statistically significant except competing financial interest, method of randomization, patients accounted for; and type II error The quality of anaesthetic research has improved in Anaesthesia and Intensive Care over the past 30 years. However; there is still room for improvement.
Polyaniline Nanowire Arrays Aligned on Nitrogen-Doped Carbon Fabric for High-Performance Flexible Supercapacitors (2013)

A combination of vertical polyaniline (PANI) nanowire arrays and nitrogen plasma etched carbon fiber cloths (eCFC) was fabricated to create 3D nanostructured PANI/eCFC composites. The small size of the highly ordered PANI nanowires can greatly reduce the scale of the diffusion length, allowing for the improved utilization of electrode materials. A two-electrode flexible supercapacitor based on PANI/eCFC demonstrates a high specific capacitance (1035 F g(-1) at a current density of 1 A g(-1)), good rate capability (88% capacity retention at 8 A g(-1)), and long-term cycle life (10% capacity loss after 5000 cycles). The lightweight, low-cost, flexible composites are promising candidates for use in energy storage device applications.
High‐affinity <scp>PD</scp>‐1 molecules deliver improved interaction with <scp>PD</scp>‐L1 and <scp>PD</scp>‐L2 (2018)

The inhibitory checkpoint molecule programmed death (PD)-1 plays a vital role in maintaining immune homeostasis upon binding to its ligands, PD-L1 and PD-L2. Several recent studies have demonstrated that soluble PD-1 (sPD-1) can block the interaction between membrane PD-1 and PD-L1 to enhance the antitumor capability of T cells. However, the affinity of natural sPD-1 binding to PD-L1 is too low to permit therapeutic applications. Here, a PD-1 variant with approximately 3000-fold and 70-fold affinity increase to bind PD-L1 and PD-L2, respectively, was generated through directed molecular evolution and phage display technology. Structural analysis showed that mutations at amino acid positions 124 and 132 of PD-1 played major roles in enhancing the affinity of PD-1 binding to its ligands. The high-affinity PD-1 mutant could compete with the binding of antibodies specific to PD-L1 or PD-L2 on cancer cells or dendritic cells, and it could enhance the proliferation and IFN-γ release of activated lymphocytes. These features potentially qualify the high-affinity PD-1 variant as a unique candidate for the development of a new class of PD-1 immune-checkpoint blockade therapeutics.