gebhart/patrepeval huggingface dataset:
A new methodology for reducing brittleness in genetic programming (2002)

Genetic programming systems typically use a fixed training population to optimize programs according to problem-specific fitness criteria. The best-of-run programs evolved by these systems frequently exhibit optimal (or near-optimal) performance in competitive survival environments explicitly represented by the training population. Unfortunately, subsequent performance of these programs is often less than optimal when situations arise that were not explicitly anticipated during program evolution. This paper describes a new methodology which promises to reduce the brittleness of best-of-run programs evolved by genetic programming systems. Instead of using a fixed set of fitness cases, the new methodology creates a new set of randomly-generated fitness cases prior to the evaluation of each generation of the evolutionary process. A genetic programming system that evolves optimized maneuvers for an extended 2D pursuer/evader problem was modified for this study. The extended 2D pursuer/evader problem is a competitive zero-sum game in which an evader attempts to escape a faster, more agile pursuer by performing specific combinations of thrusting and turning maneuvers. The pursuer uses the highly effective proportional navigation algorithm to control its trajectory towards the evader. The original genetic programming system used a fixed training set of pursuers. Each of these pursuers was uniquely identified by two parameters: the initial distance from pursuer to evader, and the angle that the velocity vector of the evader makes relative to the pursuer/evader line-of-sight at the time the pursuer is launched. The modified system implemented for this project was identical to the original system, except that it used random distances and angles to create a new set of fitness cases prior to each generation of the genetic programming run. Best-of-run programs were independently evolved using fixed and randomly-generated fitness cases. These programs were subsequently tested against a large, representative fixed population of pursuers to determine their relative effectiveness. This paper describes the implementation of both the original and modified systems, and summarizes the results of these tests.
Una visió crítica del Pla territorial general de Catalunya (2001)

Catalunya va ser la primera comunitat autonoma que va regular la funcio publica d’ordenacio del territori, que l’Estatut d’autonomia (art. 9.9) havia atribuit a la seva competencia exclusiva, conforme als minims competencials garantits a totes les comunitats autonomes en la Constitucio (art. 148.1.3). La Llei de politica territorial de Catalunya (Llei de Catalunya 23/1983, de 21 de novembre) es presenta, per tant, com el primer sistema d’ordenacio territorial de l’Estat de les autonomies. Un primer sistema d’ordenacio territorial amb uns continguts que semblen condicionats per la influencia d’elements territorials i economics. Cal parlar d’elements territorials per referir-se a les concepcions que identifiquen l’ordenacio territorial amb un sistema de planejament fisic superior. Aixi, la legislacio urbanistica tradicional havia regulat, com a instruments d’ordenacio territorial, el Pla nacional d’ordenacio i els plans directors territorials de coordinacio (art. 7 i 8 del Text refos de la Llei del sol de 1976). Si be aquests instruments mai no es van arribar a formular, almenys amb el contingut coordinador dissenyat pel legislador estatal, no obstant aixo, l’intent d’establir una jerarquia planificatoria entre plans territorials i urbanistics pot tenir origen en les regulacions urbanistiques corresponents. Aixo permetria explicar que en la Llei de politica territorial de Catalunya s’ordeni que els plans urbanistics siguin coherents amb els territorials (art. 11.4). Al mateix temps, la identificacio de continguts de gran transcendencia, que en justificarien la superioritat, en els plans dissenyats per la Llei de politica territorial de Catalunya, sembla que procedeix de la caracteritzacio de l’ordenacio del territori com l’expressio 1. El sistema d’ordenacio territorial de Catalunya. 2. El Pla territorial general de Catalunya en el sistema de fonts del dret. 3. Referencia als continguts del Pla territorial general de Catalunya.
Activities of Various 4-Aminoquinolines Against Infections with Chloroquine-Resistant Strains of <i>Plasmodium falciparum</i> (1977)

The studies reported here stemmed from a personal report by Geiman on the capacity of the 4-aminoquinoline amodiaquin to inhibit in vitro maturation of ring stages of the chloroquine-resistant Monterey strain of Plasmodium falciparum. This observation, confirmed in owl monkeys infected with this strain, led to a comparison of the activities of chloroquine, amodiaquin, amopyroquin, and dichlorquinazine (12,278 RP) against infections with various chloroquine-susceptible and chloroquine-resistant strains. The results showed that: (i) these 4-aminoquinolines were essentially equally active against infections with chloroquine-susceptible strains and (ii) the activities of amodiaquin, amopyroquin, and dichlorquinazine were reduced significantly in the face of chloroquine resistance, but (iii) well-tolerated doses of these compounds would cure infections with strains that fully resisted treatment with maximally tolerated doses of chloroquine. Two other 4-aminoquinolines, SN-8137 and SN-9584, which also exhibited activity against chloroquine-resistant parasites in vitro, displayed curative activity in monkeys infected with a chloroquine-resistant strain. These observations show that there is cross-resistance among the 4-aminoquinolines, confirming earlier findings, but indicate that the dimensions of this phenomenon are sufficiently limited so that some derivatives are therapeutically effective against infections refractory to maximally tolerated doses of chloroquine.
Shear‐wave birefringence measurement and detection in the Paris basin (1989)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1989Shear‐wave birefringence measurement and detection in the Paris basinAuthors: Frederic LefeuvreChristian ClietLaurence NicoletisFrederic LefeuvreInstitut Francais du Petrole, Christian ClietInstitut Francais du Petrole, and Laurence NicoletisInstitut Francais du Petrolehttps://doi.org/10.1190/1.1889772 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1889772FiguresReferencesRelatedDetailsCited ByCharacterization of layered anisotropic media from prestack PS-wave-reflection dataJason E. Gumble and James E. Gaiser11 September 2006 | GEOPHYSICS, Vol. 71, No. 5Analysis of Shear-Wave Polarization in VSP Data: A Tool for Reservoir Development1 December 1995 | SPE Formation Evaluation, Vol. 10, No. 04OPTIMAL ESTIMATION OF CRACK-STRIKE1Geophysical Prospecting, Vol. 40, No. 8A decade of shear-wave splitting in the Earth's crust: what does it mean? what use can we make of it? and what should we do next?Geophysical Journal International, Vol. 107, No. 3p - and SV -wave transversely isotropic phase velocities analysis from VSP dataGeophysical Journal International, Vol. 107, No. 3EXAMINATION OF A SPECTRAL METHOD FOR MEASURING THE EFFECTS OF ANISOTROPY1Geophysical Prospecting, Vol. 39, No. 5 SEG Technical Program Expanded Abstracts 1989ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1989 Pages: 1375 publication data© 1989 Copyright © 1989 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 10 Feb 2005 CITATION INFORMATION Frederic Lefeuvre, Christian Cliet, and Laurence Nicoletis, (1989), "Shear‐wave birefringence measurement and detection in the Paris basin," SEG Technical Program Expanded Abstracts : 786-790. https://doi.org/10.1190/1.1889772 Plain-Language Summary PDF DownloadLoading ...
Human platelet-derived growth factor: radioimmunoassay and discovery of a specific plasma-binding protein. (1983)

The platelet-derived growth factor (PDGF) is the principal mitogen in serum for cultured cells of mesenchymal origin. PDGF also is a potent chemotactic protein for inflammatory cells and for cells required for wound repair. Because activity levels of PDGF in biological fluids are difficult to measure, we attempted to develop a radioimmunoassay for PDGF. Rabbits were immunized with purified PDGF; the antiserum obtained was monospecific for PDGF in immunodiffusion analysis against concentrated platelet lysates, serum, and plasma. A radioimmunoassay for PDGF was developed with a sensitivity of congruent to 0.2 ng/ml. Levels of PDGF in plasma/serum were measured and compared with PDGF levels determined by a receptor-competition assay and by a standard biological assay measuring incorporation of [3H]thymidine into 3T3 cells. Radioimmunoassay showed apparent PDGF levels of 50 ng/ml in human plasma and 103 ng/ml in serum. The 50 ng/ml PDGF in plasma was unexpected because the plasma samples contained little or no platelet release products as determined by very low levels of platelet factor 4. We therefore sought an immunologically reactive PDGF molecule in human plasma. No immunologically reactive protein was detected by immunodiffusion analysis or when plasma was treated with an immunoaffinity gel. Subsequently, a 125I-PDGF-binding protein was identified; the 125I-PDGF-plasma-binding protein complex was not reactive with anti-PDGF immunoglobulin. Correction for 125I-PDGF bound by the plasma-binding protein established serum levels of PDGF of congruent to 50 ng/ml; congruent to 50 ng/ml PDGF was found in serum by radioreceptor-competition assays and by mitogenic assays as well. The plasma-binding protein may serve to clear PDGF released in the circulation, thereby limiting PDGF activity to its local interactions at the site of blood-vessel injury.
QoS-Driven Reconfigurable Parallel Computing for NoC-Based Clustered MPSoCs (2012)

Reconfigurable parallel computing is required to provide high-performance embedded computing, hide hardware complexity, boost software development, and manage multiple workloads when multiple applications are running simultaneously on the emerging network-on-chip (NoC)-based multiprocessor systems-on-chip (MPSoCs) platforms. In these type of systems, the overall system performance may be affected due to congestion, and therefore parallel programming stacks must be assisted by quality-of-service (QoS) support to meet application requirements and to deal with application dynamism. In this paper, we present a hardware-software QoS-driven reconfigurable parallel computing framework, i.e., the NoC services, the runtime QoS middleware API and our ocMPI library and its tracing support which has been tailored for a distributed-shared memory ARM clustered NoC-based MPSoC platform. The experimental results show the efficiency of our software stack under a broad range of parallel kernels and benchmarks, in terms of low-latency interprocess communication, good application scalability, and most important, they demonstrate the ability to enable runtime reconfiguration to manage workloads in message-passing parallel applications.
Interfacial Phenomena and Phase Behavior in Metered Dose Inhaler Formulations (2006)

A metered dose inhaler (MDI), contains a liquefied propellant held under pressure in a suitable container fitted with a metering valve. The drug is present as a solution or as a suspension of fine particles. Of particular interest in the field of colloid and interface science is the stabilization of fine particle suspensions. This chapter will focus on theory and experiments for developing suspension formulations for MDIs.
An Inquiry into the Self-Evaluation of Star Teacher Characteristics Necessary for Successful Urban Teaching (2020)

   This study examines the degree of agreement between three Haberman Foundation-trained facilitators’ interviews and pre-service teachers’ self-evaluations of behavioral attributes associated with successful urban teaching. Using a quasi-experimental design research approach, data for this investigation was collected from 17 subjects who are all pre-service teacher candidates enrolled in an urban, metropolitan, co-educational research university. The Star Teacher Selection Interview and the Urban Teacher Behavioral Self-Evaluation Assessment served as the assessment instruments. Overall, findings revealed that the trained interviewers rated the pre-service teacher participants much lower on many of the behavioral attributes associated with successful urban teaching than did the subjects themselves.
Experimental evaluation of a real-time scheduler for a multiprocessor system (1991)

A description is given of the design, implementation, and experimental evaluation of a multiprocessor scheduler used with robotics applications and other real-time programs. The scheduler makes decisions concerning both the assignment of processes and the scheduling of these processes on each processor such that a near-optimal numer of processor deadlines is satisfied. It assumes that process execution times, deadlines, and earliest possible start times are known.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Considerations on clinical use of T cell immunotherapy for cancer. (2003)

The recognition by effector T lymphocytes of novel antigenic targets on tumor cells is the premise of specific, targeted immunotherapy of cancer. With the molecular characterization of peptide epitopes from melanoma antigens and, more recently, broadly expressed tumor antigens, there has been considerable enthusiasm for clinical evaluation of peptide tumor vaccines. Immunologic monitoring of vaccinated patients has demonstrated an expansion of CD8+ T cells that react with the relevant peptide and, more importantly, with native tumor. In most instances, however, vaccine-induced CD8+ T cell responses alone have not been sufficiently robust or sustained to translate into a high percentage of durable clinical responses. Vaccine strategies have also utilized dendritic cells (DCs) that have been modified to present tumor antigens. The superior antigen-processing capacity and co-stimulatory function of DCs convey a powerful stimulatory signal to both CD4+ and CD8+ T cells. Several strategies are attempting to broaden the immune response beyond single antigens by introducing the entire complement of tumor antigens into DCs. Adoptive immunotherapy is a promising strategy to recover tumor-reactive precursor T cells from patients, stimulate them to induce numerical expansion, and then re-infuse them. Ex vivo manipulation of the tumor-reactive T cells also permits cytotoxic therapy to be administered to the patient without damaging the effector cells. Recently, host lymphodepletion prior to adoptive transfer of effector T cells has resulted in an extremely high and sustained frequency of effectors that has achieved therapeutic efficacy against bulky metastatic disease in a substantial fraction of treated patients.
Suppression of lung metastasis of B16 mouse melanoma by N-acetylglucosaminyltransferase III gene transfection. (1995)

The beta 1-6 structure of N-linked oligosaccharides, formed by beta-1,6-N-acetylglucosaminyltransferase (GnT-V), is associated with metastatic potential. We established a highly metastatic subclone, B16-hm, from low metastatic B16-F1 murine melanoma cells. The gene encoding beta-1,4-N-acetylglucosaminyltransferase (GnT-III) was introduced into the B16-hm cells, and three clones that stably expressed high GnT-III activity were obtained. In these transfectants, the affinity to leukoagglutinating phytohemagglutinin was reduced, whereas the binding to erythroagglutinating phytohemagglutinin was increased, indicating that the level of beta 1-6 structure was decreased due to competition for substrate between intrinsic GnT-V and ectopically expressed GnT-III. Lung metastasis after intravenous injection of the transfectants into syngeneic and nude mice was significantly suppressed, suggesting that the decrease in beta 1-6 structure suppressed metastasis via a mechanism independent of the murine system. These transfectants also displayed decreased invasiveness into Matrigel and inhibited cell attachment to collagen and laminin. Cell growth was not affected. Our results demonstrate a causative role for beta 1-6 branches in invasion and cell attachment in the extravasation stage of metastasis.
Fuzzy model-reference adaptive control (2002)

This paper proposes a fuzzy model-reference adaptive control (fuzzy-MRAC) to deal with controlling a plant with unknown parameters. The proposed method uses the fuzzy basis function expansion to represent the unknown, slowly-varying parameters in a plant. The use of fuzzy basis function expansion (FBFE) to represent the unknown parameters changes the identification problem from identifying slowly-varying parameters to identifying constant parameters of the FBFE. That is, the varying property of unknown parameters is absorbed into the fuzzy sets. This data representation is substantiated by the Stone Weierstrass theorem which indicates that any continuous function can be represented by the FBFE. Since constant parameters are easier to estimate than varying parameters, better performance can be expected from the fuzzy-MRAC than the traditional MRAC. Furthermore, the adaptation scheme of the proposed fuzzy-MRAC is based on both the trading error and the prediction error. Combining these two sources of error information, the proposed fuzzy-MRAC will provide more adaptation power than a traditional adaptive control. Since the proposed fuzzy-MRAC can be considered as an extension of the traditional MRAC, its stability and convergence properties are preserved. Computer simulations were conducted to show the validity and the performance of the proposed fuzzy-MRAC and its improvement over the traditional MRAC.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Can Massless Particles be Charged? (1962)

It is shown that for particles of spin one or larger, Lorentz invariance, masslessness, and conventional electromagnetic coupling are mutually incompatible.Received 25 September 1961DOI:https://doi.org/10.1103/PhysRev.125.1055©1962 American Physical Society
Analysis of individual classification of lameness using automatic measurement of back posture in dairy cattle (2012)

Currently, diagnosis of lameness at an early stage in dairy cows relies on visual observation by the farmer, which is time consuming and often omitted. Many studies have tried to develop automatic cow lameness detection systems. However, those studies apply thresholds to the whole population to detect whether or not an individual cow is lame. Therefore, the objective of this study was to develop and test an individualized version of the body movement pattern score, which uses back posture to classify lameness into 3 classes, and to compare both the population and the individual approach under farm conditions. In a data set of 223 videos from 90 cows, 76% of cows were correctly classified, with an 83% true positive rate and 22% false positive rate when using the population approach. A new data set, containing 105 videos of 8 cows that had moved through all 3 lameness classes, was used for an ANOVA on the 3 different classes, showing that body movement pattern scores differed significantly among cows. Moreover, the classification accuracy and the true positive rate increased by 10 percentage units up to 91%, and the false positive rate decreased by 4 percentage units down to 6% when based on an individual threshold compared with a population threshold.
Molecular signaling pathways regulating muscle proteolysis during atrophy (2005)

The maintenance of muscle mass requires a delicate balance between catabolic factors and anabolic factors. These signals inversely modulate the activity of several key regulatory pathways including the phosphoinositide-3 kinase/AKT and nuclear factor kappa B systems, which control the transcription of components of the ubiquitin-proteasome proteolytic pathway activity, the activity of caspase-3, and perhaps other proteolytic functions. When levels of insulin or insulin-like growth factor-1 are insufficient or inflammatory cytokine production is increased, muscle atrophy ensues.
Dacota: Post-silicon validation of the memory subsystem in multi-core designs (2009)

The number of functional errors escaping design verification and being released into final silicon is growing, due to the increasing complexity and shrinking production schedules of modern processor designs. Recent trends towards chip multiprocessors (CMPs) are exacerbating the problem because of their complex and sometimes non-deterministic memory subsystems, prone to subtle but devastating bugs. This deteriorating situation calls for high-efficiency, high-coverage results in functional validation, results that are be achieved by leveraging the performance of post-silicon validation, that is, those verification tasks that are executed directly on prototype hardware. The orders-of-magnitude faster testing in post-silicon enables designers to achieve much higher coverage before customer release, but only if the limitations of this technology in diagnosis and internal node observability could be overcome. In this work, we unlock the full performance of post-silicon validation through Dacota, a new high-coverage solution for validating memory operation ordering in CMPs. When activated, Dacota reconfigures a portion of the cache storage to log memory accesses using a compact data-coloring scheme. Logs are periodically aggregated and checked by a distributed algorithm running in-situ on the CMP to verify correct memory operation ordering. When the design is ready for customer shipment, Dacota can be deactivated, releasing all cache storage, and only leaving a small silicon area footprint, less than 0.01% (three orders of magnitude smaller than previous solutions). We found experimentally that Dacota is effective in exposing memory subsystem bugs, and it delivers its high coverage capabilities at a 26% performance slowdown (only during validation) for real-world applications.
Electron Mirror Observations of Semiconductor Surfaces at Low Temperatures (1965)

Abstract A new type of electron mirror microscope is described schematically. The microscope allows the observation of electrical micro‐fields on semiconductor surfaces in the temperature range 77 to 1300 °K. Preliminary results of observations on silicon surfaces at low temperatures are presented. It is suggested that the observed pictures can be interpreted in terms of surface fields resulting from the trapping of minority carriers. Results concerning impurity precipitation in silicon and germanium are also given.
An overview of polarimetric sensing techniques and technology with applications to different research fields (2014)

<p>\n\tWe report the main conclusions from an interactive, multidisciplinary workshop on "Polarimetric Techniques and Technology", held on March 24-28 2014 at the Lorentz Center in Leiden, the Netherlands. The work- shop brought together polarimetrists from different research fields. Participants had backgrounds ranging from academia to industrial RD. Here we provide an overview of polarimetric instrumentation in the optical regime geared towards a wide range of applications: atmospheric remote sensing, target detection, astronomy, biomedical applications, etc. We identify common approaches and challenges. We list novel polarimetric techniques and polarization technologies that enable promising new solutions. We conclude with recommendations to the polarimetric community at large on joint efforts for exchanging expertise.</p>