gebhart/patrepeval huggingface dataset:
942. The properties and reactions of dimethanesulphonyl peroxide (1964)

R. N. Haszeldine, R. B. Heslop and J. W. Lethbridge, J. Chem. Soc., 1964, 4901 DOI: 10.1039/JR9640004901
Advances in Drug Research (1964)

The concept of emergence dissolvence in drug research, B. Testa and L.B. Kier sense and non-sense in toxicity assessment of medicinal products, A.G. Rauws, E.J. De Waal and J.W. van der Laan the concept of chiral conformers and its significance in molecular pharmacology, M. Simonyi combinational libraries for enhanced drug discovery, E.R. Felder and D. Poppinger reversal of chloroquine resistance in malaria - a new concept of chemotherapy, S. Batra and A.P. Bhaduri.
Regulation of pre-mRNA splicing by antisense oligonucleotides. (1999)

Numerous human diseases arise from mutations that result in aberrant RNA splicing. To date, traditional therapeutic approaches have not been successful in targeting these mutations and restoring correct splicing. Antisense oligonucleotides may provide a novel and effective way to restore correct splicing in mutant genes. Historically, antisense oligonucleotides have been used to decrease mRNA transcripts of disease gene products through an RNase H-dependent mechanism. Through chemical modifications of antisense oligonucleotides, it has been possible to generate compounds that bind to specific mRNA sequences with high affinity, yet do not cause the degradation of the RNA transcript. By directing chemically-modified oligonucleotides to regions of the pre-mRNA important for splicing, it may be possible to inhibit splicing at mutant splice sites. This novel and relatively unexplored application of antisense technology could be of tremendous therapeutic benefit in the treatment of human disease.
PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints (2005)

The ATM (ataxia-telangiectasia mutated) and ATR (ataxia-telangiectasia and Rad3-related) kinases respond to DNA damage by phosphorylating cellular target proteins that activate DNA repair pathways and cell cycle checkpoints in order to maintain genomic integrity. Here we show that the oncogenic p53-induced serine/threonine phosphatase, PPM1D (or Wip1), dephosphorylates two ATM/ATR targets, Chk1 and p53. PPM1D binds Chk1 and dephosphorylates the ATR-targeted phospho-Ser 345, leading to decreased Chk1 kinase activity. PPM1D also dephosphorylates p53 at phospho-Ser 15. PPM1D dephosphorylations are correlated with reduced cellular intra-S and G2/M checkpoint activity in response to DNA damage induced by ultraviolet and ionizing radiation. Thus, a primary function of PPM1D may be to reverse the p53 and Chk1-induced DNA damage and cell cycle checkpoint responses and return the cell to a homeostatic state following completion of DNA repair. These homeostatic functions may be partially responsible for the oncogenic effects of PPM1D when it is amplified and overexpressed in human tumors.
Field Displacement Isolators at 4,6,11, and 24 KMC (1957)

Performance of ferrite field displacement isolators at various frequency bands is described. Single and double-slab isolaton have been constructed in rectangular waveguide. Four single-slab isolators are reported in the following frequency bands: 3700-4200 mc; 5925-6425 mc; 10,700-11,700 mc and 23,500-24,470 mc; one double-slab isolator is described in the frequency range 10,700-11,700 mc.
Subcellular distribution of muscarinic acetylcholine receptors in rat exorbital lacrimal gland. (1990)

The muscarinic acetylcholine receptor (MAChR) is an important mediator of parasympathetic regulation of secretion by the rat exorbital lacrimal gland. In order to survey the subcellular distribution of MAChR in lacrimal acinar cells, we have measured the binding of the specific muscarinic cholinergic antagonist [3H]-quinuclidinyl benzilate ([3H]-QNB) to membrane samples isolated from rat exorbital lacrimal glands by differential and equilibrium density gradient centrifugation. Binding of [3H]-QNB in all membrane fractions was consistent with the presence of a single class of receptor which was muscarinic in nature on the basis of its Kd for [3H]-QNB (0.30-0.35 nM) and its ability to interact with the muscarinic agonists carbachol and methachol and the antagonist atropine. MAChR were present at the highest specific activity in acinar cell basal-lateral plasma membrane-derived populations, where Bmax was as high as 1960 fmole/mg protein. However, the density distributions of MAChR and of other membrane markers indicated that the receptors were present also in membranes derived from cytoplasmic structures, where Bmax values ranged from 50.4 to 152.8 fmole/mg protein. Stimulation with 10 microM carbachol for 30 min led to a 20% (P less than 0.05) increase in the relative MAChR content of a population of membranes derived from the acinar cell basal-lateral membrane; an apparent tendency for MAChR activity to decrease in other membrane populations suggests that stimulation might cause a redistribution of MAChR between cytoplasmic pools and the cell surface membranes.
Initial investigations into the damping characteristics of wire rope vibration isolators (1987)

This study evaluated the efficacy of behavioral techniques (i.e., parent training, modeling, and desensitization) to facilitate use of nasal continuous positive airway pressure (CPAP) in four children with obstructive sleep apnea (OSA) secondary to anatomic disorder of the upper airway. All patients tolerated CPAP with training: Polysomnographic data revealed improvement in sleep architecture, apnea, and oxygenation, and patients were discharged on CPAP units. All patients continued to use CPAP throughout the 3-month follow-up period and none required additional treatment for OSA. Three of four patients continued to use CPAP at the 9-month follow-up visit. Treatment resulted in improvements in alertness, attention/concentration, and behavior/temperament. Children generally have been considered poor candidates for nasal CPAP, and historically they have been offered instead more invasive procedures. This study suggests that CPAP is a viable treatment for such children when paired with behavioral interventions that facilitate its use.
Access Rights Administration in Role-Based Security Systems (1994)

This paper examines the concept of role-based protection and, in particular, role organization. From basic role relationships, a model for role organization is developed. The role graph model, its operator semantics based on graph theory and algorithms for role administration are proposed. The role graph model, in our view, presents a very generalized form of role organization for access rights administration. It is shown how the model simulates other organizational structures such as hierarchies [TDH92] and privilege graphs [Bal90].
2-Benzazepines. 8. Zerovalent nickel mediated biaryl synthesis of an anxiolytic pyrimido[5,4-d][2]benzazepine (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT2-Benzazepines. 8. Zerovalent nickel mediated biaryl synthesis of an anxiolytic pyrimido[5,4-d][2]benzazepineDavid L. Coffen, Beatrice Schaer, Fred T. Bizzarro, and Julia B. CheungCite this: J. Org. Chem. 1984, 49, 2, 296–300Publication Date (Print):January 1, 1984Publication History Published online1 May 2002Published inissue 1 January 1984https://pubs.acs.org/doi/10.1021/jo00176a015https://doi.org/10.1021/jo00176a015research-articleACS PublicationsRequest reuse permissionsArticle Views760Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
OpenSDWN: Programmatic Control overHome and Enterprise WiFi (2015)

The quickly growing demand for wireless networks and the numerous application-specific requirements stand in stark contrast to today’s inflexible management and operation of WiFi networks. In this paper, we present and evaluate OPENSDWN, a novel WiFi architecture based on an SDN/NFV approach. OPENSDWN exploits datapath programmability to enable service differentiation and fine-grained transmission control, facilitating the prioritization of critical applications. OPENSDWN implements per-client virtual access points and per-client virtual middleboxes, to render network functions more flexible and support mobility and seamless migra-tion. OPENSDWN can also be used to out-source the control over the home network to a participatory interface or to an Internet Service Provider.
NaXi Pictographs Input Method and WEFT (2009)

NaXi Pictograph , which is the only hieroglyph in use is important for researching into the evolution of the character. In the past, processing NaXi Pictograph by hand, that is very inefficient. The NaXi Pictograph information processing modules is developed, such as pictograph Outline Font lib, the input method module, the embedded module and so on. A method of NaXi Pictographs Outline font extraction is proposed, which has been testified better in the Linux. As the specialty of NaXi Pictographs,two input mothods -- NaXi pictographs pinyin and graphic primitive input method are advanced, by evaluating ,which is found that the second is better than the first in precision. For display in web, The web embedding fonts technology of NaXi Pictographs is brought forward, and The web embedding fonts technology of NaXi pictographs makes Internet clients browse NaXi pictographs web without downloading NaXi pictographs font. The development of the NaXi Pictograph Information Processing System is significant to research into NaXi pictographs and apply it.
The effects of general anaesthesia on nerve‐motor response characteristics (rheobase and chronaxie) to peripheral nerve stimulation (2014)

Summary Using a simple surface nerve stimulation system, I examined the effects of general anaesthesia on rheobase (the minimum current required to stimulate nerve activity) and chronaxie (the minimum time for a stimulus twice the rheobase to elicit nerve activity). Nerve stimulation was used to elicit a motor response from the ulnar nerve at varying pulse widths before and after induction of general anaesthesia. Mean (SD) rheobase before and after general anaesthesia was 0.91 (0.37) mA (95% CI 0.77–1.04 mA) and 1.11 (0.53) mA (95% CI 0.92–1.30 mA), respectively. Mean (SD) chronaxie measured before and after general anaesthesia was 0.32 (0.17) ms (95% CI 0.26–0.38 ms) and 0.29 (0.13) ms (95% CI 0.24–0.33 ms), respectively. Under anaesthesia, rheobase values increased by an average of 20% (p = 0.05), but chronaxie values did not change significantly (p = 0.39). These results suggest that threshold currents used for motor response from nerve stimulation under general anaesthesia might be higher than those used in awake patients.
Proteomic analysis of hypoxia‐induced tube breakdown of an <b><i>in vitro</i></b> capillary model composed of HUVECs: Potential role of p38‐regulated reduction of HSP27 (2008)

We recently reported that hypoxia could induce the breakdown of capillary-like tubes formed by human umbilical vein endothelial cells (HUVECs) and that this breakdown was regulated by p38 and not by a caspase cascade, although the exact molecular mechanisms remain unknown. The aim of this study was to identify proteins that regulated hypoxia-induced tube breakdown through p38-regulated and caspase-independent mechanisms. The involvement of adhesion proteins, integrins, VE-cadherin, PECAM-1, and occludin was first investigated. Although some of these proteins decreased after hypoxia, none of them met the conditions of being quantitatively restored by p38 inhibition but not by caspase inhibition. We then conducted 2-D DIGE coupled with MALDI-TOF/TOF-MS to identify altered protein expression. The differential proteomic analysis of tube-forming HUVECs treated with normoxia or hypoxia and treated with hypoxia in the presence or absence of SB203580, a specific p38 inhibitor, revealed the involvement of heat shock proteins in this tube breakdown. We also confirmed that the amount of HSP27 and HSP70 changed in a p38-regulated and caspase-independent manner during hypoxia. Knocking down HSP27 expression using RNAi further augmented hypoxia-induced tube breakdown. Taken together, it was shown that p38-regulated and caspase-independent reduction of HSP27 plays an important role in hypoxia-induced tube breakdown.
Implementation and Experimental Investigation of Sensorless Speed Control With Initial Rotor Position Estimation for Interior Permanent Magnet Synchronous Motor Drive (2005)

In this paper, a new approach to sensorless speed control and initial rotor position estimation for interior permanent magnet synchronous motor (IPMSM) drive is presented. In rotating condition, speed and rotor position estimation of IPMSM drive are obtained through an extended Kalman filter (EKF) algorithm simply by measurement of the stator line voltages and currents. The main difficulty in developing an EKF for IPMSM is the complexity of the dynamic model expressed in the stationary coordinate system. This model is more complex than that of the surface PMSM, because of the asymmetry of the magnetic circuit. The starting procedure is a problem under sensorless drives, because no information is available before starting. The initial rotor position is estimated by a suitable sequence of voltage pulses intermittently applied to the stator windings at standstill and the measurement of the peak current values of the current leads to the rotor position. Magnetic saturation effect on the saliency is used to distinguish the north magnetic pole from the south. To illustrate our work, we present experimental results for an IPMSM obtained on a floating point digital signal processor (DSP) TMS320C31/40 MHz based control system.
MONOPOLE-BASED RECTENNA FOR MICROWAVE ENERGY HARVESTING OF UHF RFID SYSTEMS (2012)

This paper presents a rectifying antenna (rectenna) for the harvesting of the microwave energy associated to UHF (Ultra- High Frequency) Radio Frequency IDentiflcation (RFID) systems. The proposed device uses a capacitively loaded T-shaped monopole with a coplanar waveguide feeding line as receiving antenna and a flve-stage voltage multiplier as rectifler. Experimental results demonstrating an RF-to-DC conversion e-ciency of about 54% with an input power density of 80W/cm 2 will be presented and discussed.
15 cm duoPIGatron ion source (1976)

The 10-cm (grid diameter) duoPIGatron ion source produces pulsed hydrogen ion beams of 10 to 15 A beam current in the 20- to 40-keV energy range for a duration of a few tenths of a second. To fulfill the requirements of the next generation of high-power neutral beam injectors for heating plasmas in CTR devices, this source has been enlarged to a version 15-cm in grid diameter. In addition, by utilizing a magnetic multipole line cusp field confinement method, the plasma created is characterized over the 15 cm grid diameter by a noise level within +- 10 percent and spatial density variations within +- 15 percent at a density on the order of 10/sup 12/ cm/sup -3/. This larger source has operated reliably and produced a beam current exceeding 30 A of hydrogen at 27 keV. Initial operation of a 20-cm version of this source employing line cusp confinement has produced an extraction current of 60 A at 33 keV.
Echocardiographic Evaluation in Asymptomatic Relatives of Patients with Dilated Cardiomyopathy Reveals Preclinical Disease (2005)

Treatable asymptomatic dilated cardiomyopathy was identified in 4.6% of asymptomatic relatives. In addition, left ventricular enlargement and depressed fractional shortening were common in asymptomatic relatives of patients with dilated cardiomyopathy and were associated with a statistically significant medium-term risk for disease progression. Evaluation of relatives of patients with cardiomyopathy is recommended.
NetAnalyzer: A retrospective network analysis tool (1997)

A wide range of public domain and commercial tools currently exist to help network administrators manage networks. However, most of these are real-time analysis tools, and so provide more support in monitoring network activity. A very small subset of these tools assist the network administrator and/or designer in reconfiguring the network as well as identifying optimal resource allocations. The goal of the tool described in this paper is to help in designing and/or reconfiguring of networks for optimal allocation of both clients and file-systems in a distributed computing environment. This paper describes NetAnalyzer, a retrospective network analysis tool running under SUN UNIX (4.1.3) Operating System. The tool uses a utility to passively collect statistics on an Ethemet-based distributed computing environment by operating the interface in a promiscuous mode. The tool allows the user to obtain statistics on the Ethernet utilization, analyze the traffic between the subnetwork of a partitioned network, and also provides comprehensive knowledge of how the various file-system partitions on every server are used in the system. This information would assist the network administrator in reconfiguring the network to meet its requirements in a cost-effective manner.
All-organic integrated emissive pixels (2003)

We have fabricated fully-integrated all-organic active matrix emissive pixels in which an organic light emitting diode (LED) is directly integrated into the channel region of an organic thin film transistor (TFT). Charge carriers enter the organic emissive layer directly from the TFT channel, thus eliminating the need for TFT drain and LED anode contacts.
Head Analysis in Air Flow on Near-Field Optical Disk System with 2-Axis Actuator (2005)

Several near field optical disk systems have been proposed and are expected to be the tools for realizing large-capacity optical disk storage systems. However, there remains a concern as to whether removability can be realized in near-field optical disk systems. To resolve this concern, we analyze a near-field optical head installed onto a 2-axis actuator in an air flow. Finally, we conclude that a conical head and the active servo of a 2-axis actuator contribute to the stability of near-field playability with respect to dust robustness.
Anthocyanin-Based Natural Colorants:  A New Source of Antiradical Activity for Foodstuff (2000)

The antiradical capacity (radical scavenger capacity, RSC) of anthocyanin-based fruit extracts prepared in the laboratory (black chokeberry, black-thorn, and strawberry) was studied by using the 2, 2-diphenyl-1-picrylhydrazyl radical (DPPH(*)). To determine their RSC, the second-order rate constant (k(2)) for the oxidation of these extracts by DPPH(*) was calculated. The value of k(2) was compared to that used in the food industry as natural (alpha-tocopherol) or synthetic (butylated hydroxytoluene (BHT) and butylated hydroxyanisole (BHA)) antioxidants, as well as for a commercial elderberry concentrate and a synthetic colorant (Ponceau 4R). The k(2) values ((mg/mL)(-)(1) s(-)(1)), in methanol at 25 degrees C, were 1.87, 0.7, 0.42, 0.2, 0.05, 0.03, and 0.008 for alpha-tocopherol, black chokeberry, BHA, black-thorn, BHT, strawberry, and elderberry, respectively. Ponceau 4R lacked RSC. Therefore, these natural colorants proved to be a combined source of color and RSC for food material.
On‐line monitoring of hybridoma cell growth using a laser turbidity sensor (1992)

A high-sensitivity turbidity probe was used for on-line monitoring of the cell concentration in batch hybridoma cultivation. Good correlation between off-line cell counts and the linearized sensor signal was found. The quality of the signal was sufficiently high to provide for on-line estimation of the specific growth rate using an efficient filtering procedure. These positive results suggest that such laser turbidity sensors will facilitate development of systems for on-line monitoring and control of animal cell cultivations.
β<sub>2</sub>‐Inhibin contains the active core of human seminal plasma β‐inhibin: synthesis and bioactivity (1985)

The complete synthesis of the C-terminal 28 residues segment 67-94 of human seminal plasma beta-Inhibin, called beta 2-Inhibin, is reported. The Inhibin-like activity of the native 94 amino acids beta-Inhibin is compared to that of the synthetic replica of beta 2-Inhibin. In all assays used both peptides effectively suppress the FSH release induced by LHRH but have little effect on the LH release. In the mouse both peptides are equipotent on a mole basis. In the rat the synthetic beta 2-Inhibin is 3-10 times more potent than beta-Inhibin. Both peptides are active in rat anterior pituitary primary culture assays where maximum suppression of FSH release induced by LHRH occurs around 300 pmol/ml of beta 2-Inhibin. In contrast, maximum suppression of FSH release in the mouse pituitary assay occurs at 10-15 pmol/ml of either Inhibin.
Review: Preventing diabetes in the obese: the XENDOS study and its context (2004)

This article reviews the evidence, from both observational epidemiology and randomised clinical trials, that lifestyle modification as well as anti-diabetic drugs can reduce or delay the development of diabetes in overweight and obese patients with IGT. Particular consideration is given to the recently published XENDOS study which showed that the combination of orlistat and lifestyle changes over four years is safe and well tolerated, results in a weight loss of about six kg and reduces the risk of developing diabetes by 45% in obese IGT patients. Thus, addition of orlistat to lifestyle intervention has a greater diabetes-preventing effect than lifestyle modification alone.
A Hybrid Plasmonic Waveguide for Subwavelength Confinement and Long Range Propagation (2008)

We describe the coupling between surface plasmons and semiconductor fiber modes across a nano-scale gap leading to “capacitor-like” energy storage for sub-wavelength transmission and long range propagation. The approach could enable nano-scale semiconductor-based plasmonics.
Cytologic detection of Wuchereria bancrofti microfilariae in urine collected during a routine workup for hematuria. (1983)

A 23-year-old Guyanese man experienced intermittent, total, painless, gross hematuria for a month for which he sought medical attention at the Kings County Hospital Center in Brooklyn. Hematuria was accompanied by weakness but not by frequency of urination or burning on urination. Catheterized urine at the time of cystoscopy and each of two subsequent voided specimens examined cytologically contained sheathed microfilariae. Distinguishing features of the microfilariae were well demonstrated with the Papanicolaou stain. The well-stained nuclei, which did not extend into the clear zone, and the distinct, pale-stained sheath led to the positive identification of the microfilariae as Wuchereria bancrofti. The Papanicolaou stain may well be the stain of choice for the identification of microfilariae in the blood. The excellent detail obtained with this routine cytologic stain is as good as that with Giemsa, which does not stain the sheath.