gebhart/patrepeval huggingface dataset:
Structural and Functional Modularity of the Orange Carotenoid Protein: Distinct Roles for the N- and C-Terminal Domains in Cyanobacterial Photoprotection  (2014)

The orange carotenoid protein (OCP) serves as a sensor of light intensity and an effector of phycobilisome (PB)-associated photoprotection in cyanobacteria. Structurally, the OCP is composed of two distinct domains spanned by a single carotenoid chromophore. Functionally, in response to high light, the OCP converts from a dark-stable orange form, OCP(O), to an active red form, OCP(R). The C-terminal domain of the OCP has been implicated in the dynamic response to light intensity and plays a role in switching off the OCP's photoprotective response through its interaction with the fluorescence recovery protein. The function of the N-terminal domain, which is uniquely found in cyanobacteria, is unclear. To investigate its function, we isolated the N-terminal domain in vitro using limited proteolysis of native OCP. The N-terminal domain retains the carotenoid chromophore; this red carotenoid protein (RCP) has constitutive PB fluorescence quenching activity comparable in magnitude to that of active, full-length OCP(R). A comparison of the spectroscopic properties of the RCP with OCP(R) indicates that critical protein-chromophore interactions within the C-terminal domain are weakened in the OCP(R) form. These results suggest that the C-terminal domain dynamically regulates the photoprotective activity of an otherwise constitutively active carotenoid binding N-terminal domain.
Anosmia Leads to a Loss of Gray Matter in Cortical Brain Areas (2010)

Chronic olfactory disorders, including the complete loss of the sense of smell (anosmia), are common. Using voxel-based morphometry (VBM) in magnetic resonance imaging (MRI), structural changes in the cerebral gray matter (GM) of a group of patients with anosmia compared with a normosmic, healthy control group were evaluated. Patients with anosmia presented a significant decrease of GM volume mainly in the nucleus accumbens with adjacent subcallosal gyrus, in the medial prefrontal cortex (MPC) including the middle and anterior cingulate cortices, and in the dorsolateral prefrontal cortex (dlPFC). These areas are part of the limbic loop of the basal ganglia and except the dlPFC secondary olfactory areas. They also play an important role in many neurological diseases. Furthermore, volume decreases in smaller areas like the piriform cortex, insular cortex, orbitofrontal cortex, hippocampus, parahippocampal gyrus, supramarginal gyrus, and cerebellum could be seen. Longer disease duration was associated with a stronger atrophy in the described areas. No local increases in the GM volume could be observed. A comparison with results of an additionally executed functional MRI study on olfaction in healthy subjects was performed to evaluate the significance of the observed atrophy areas in cerebral olfactory processing. To our knowledge, this is the first study on persisting structural changes in cortical GM volume after complete olfactory loss.
Supply chain risk management (2005)

Purpose This paper seeks to understand business requirements for supply chain risk management (SCRM) from a practitioner perspective. Design/methodology/approach Based on the findings from an exploratory quantitative survey and qualitative focus group discussions with supply chain managers, some issues of SCRM are derived and structured along the three conceptual levels of “philosophy”, “principles” and “processes”. Findings The survey showed that 44 per cent of all eight responding companies expect the vulnerability of their supply chains to increase in the next five years. However, the concept of SCRM is still in its infancy. Originality/value The paper contributes to our knowledge on SCRM by presenting the business requirements from a practitioner perspective and by deriving a structure for an integrated approach to SCRM which can guide further research.
National Images of Canada and the United States: Their Structure, Coherence, and Meaning (1990)

(1990). National Images of Canada and the United States: Their Structure, Coherence, and Meaning. American Review of Canadian Studies: Vol. 20, No. 3, pp. 327-355.
EL MANEJO DE LA MUERTE EN LA LITERATURA MEXICANA, M S INTENSO QUE EN EL RESTO DE AL (2000)

EL DOCTOR ANDREI KOFMAN, CATEDRATICO DEL DEPARTAMENTO DE LITERATURA DE AMERICA Y EUROPA, DE LA ACADEMIA DE CIENCIAS DE RUSIA, Y QUE EN MEXICO ESTUDIA LA OBRA DE CARLOS FUENTES, OCTAVIO PAZ Y JUAN RULFO, AUTORES A LOS QUE CONSIDERA COMO LOS MAS DESTACADOS DE LA NARRATIVA MEXICANA CONTEMPOR NEA, OFRECIO UNA CHARLA EN EL CENTRO COORDINADOR Y DIFUSOR DE ESTUDIOS LATINOAMERICANOS EN TORNO AL TRABAJO DE INVESTIGACION QUE SE REALIZA EN RUSIA SOBRE LA CULTURA LATINOAMERICANA. EXPRESO QUE LA VIOLENCIA Y LA MUERTE SON DOS NUCLEOS MENTALES Y ARTISTICOS PECULIARES DE LA LITERATURA MEXICANA QUE NO SE MANIFIESTAN CON LA MISMA INTENSIDAD EN EL RESTO DE LA LITERATURA LATINOAMERICANA.
A monolithic mosaic of photon sensors for solid-state imaging applications (1966)

Monolithic silicon mosaics of photosensor elements have been developed for solid-state imaging applications. The physical structure, design considerations, and performance characteristics of these electrooptical devices as applied to image converter applications are discussed. The sensing monolith consists of a square 50 by 50 mosaic of phototransistor elements on 0.010 inch centers which are interconnected both by internally diffused strips and by vapor deposited surface bars. Fifty <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">X</tex> and fifty <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Y</tex> external leads provide access to any individual element <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">X_{b}Y_{a}</tex> of the mosaic. Fabrication of this 2500 element mosaic involves the techniques of planar passivation, epitaxial growth, solid-state diffusion, and thin-film vacuum evaporation. A discussion of sensor operation includes mechanisms of phototransistor action, electrooptical conversion efficiency, and element-to-element crosstalk minimization. An evaluation of the electrooptical transfer characteristics of the mosaic sensor elements are presented. Uniformity of element response is typically better than 85% for response within a 3 : 1 range and 75% for response within a 2 : 1 range. Several shades of gray can be imaged simultaneously. The mosaic dynamic range extends over 3.5 orders of incident illumination energy or five orders of output photocurrent. The minimum and maximum detectable signals are approximately 10.0 nW and 1.0 roW, respectively. Sensitivity is of the order of 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> to 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> µA/mW in the linear portion of the transfer curve.
Structural Effects on Highly Directional Far-Field Emission Patterns of GaN-Based Micro-Cavity Light-Emitting Diodes With Photonic Crystals (2010)

This study theoretically and experimentally investigates the highly directional far-field emission patterns of GaN photonic crystal (PhC) micro-cavity light-emitting diodes (MCLEDs) depending on varying structural parameters. Angular-spectra-resolved electroluminescence measurements reveals the behavior of guided-mode extraction which is significantly affected by the structural parameters of GaN PhC MCLEDs, where the GaN cavity thickness decides the extracted guided mode numbers, PhC lattice constant influences the distribution of far-field emission, and PhC hole depth affects the interaction with guided modes. The proposed GaN ultrathin MCLED (uMCLED) with PhC lattice constant of 420 nm and deep hole depth of 250 nm exhibited a maximum output light extraction efficiency of 248% under one-watt input power compared to GaN non-PhC uMCLED and produced a directional far-field emission pattern at half intensity near 17^ . The present results indicate that highly directional light extraction enhancement could contribute to developments of many applications, especially for etendue-limited applications such as pico- projectors.
Variables Affecting Test-Retest Variability Of Heidelberg Retina Tomograph II Stereometric Parameters (2002)

The test-retest variability of Heidelberg Retina Tomograph II stereometric parameters is comparable to that reported for the Heidelberg Retina Tomograph. Eyes with uncorrected astigmatism more than 1 D and poor visual acuity may have a higher variability of Heidelberg Retina Tomograph II stereometric parameters.
Review: Architectural Judgement by Peter Collins (1972)

Book Review| March 01 1972 Review: Architectural Judgement by Peter Collins Architectural JudgementPeter Collins Lewis N. Kremer Lewis N. Kremer Search for other works by this author on: This Site PubMed Google Scholar Journal of the Society of Architectural Historians (1972) 31 (1): 78–79. https://doi.org/10.2307/988741 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Lewis N. Kremer; Review: Architectural Judgement by Peter Collins. Journal of the Society of Architectural Historians 1 March 1972; 31 (1): 78–79. doi: https://doi.org/10.2307/988741 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentJournal of the Society of Architectural Historians Search This content is only available via PDF. Copyright 1972 The Society of Architectural Historians Article PDF first page preview Close Modal You do not currently have access to this content.
Profinet IO IRT Message Scheduling (2009)

This paper presents an algorithm that allows one to create a static schedule of the Profinet IO IRT communication, which is an industrial Ethernet protocol standardised in IEC$\;$61158. This algorithm offers an alternative to the available commercial tool, providing comparable results regarding the resulting time schedule length. Furthermore, we extend the problem by useful time constraints providing a greater flexibility with respect to the individual messages. Due to this flexibility, it is possible to place the selected messages in various parts of the communication cycle, to define end-to-end delays, or to increase the computational time available for the main-controller application, for example. The solution is based on a formulation of the Profinet IO IRT scheduling problem in terms of the Resource Constrained Project Scheduling with Temporal Constraints (PS|temp|Cmax).
Triple quantum well electron transfer infrared modulator (1992)

In this letter, we present a new bicolor infrared modulator using intersubband absorptions in quantum wells. The structure consists of two wells of different widths on either side of a reservoir of electrons. Depending on the sign of the electric field, the electrons transfer either into the wide well or into the narrow well, and then give rise to an intersubband absorption of the corresponding wavelength. With no applied bias, all the carriers are located in the reservoir and no absorption occurs in the midinfrared wavelength range of interest. Two samples are studied by transmission measurements in a Fourier transform infrared spectrometer. The great importance of the space charge effects in this type of device is evidenced and simulated by a self-consistent model.
Artificial Affinity Proteins as Ligands of Immunoglobulins (2015)

A number of natural proteins are known to have affinity and specificity for immunoglobulins. Some of them are widely used as reagents for detection or capture applications, such as Protein G and Protein A. However, these natural proteins have a defined spectrum of recognition that may not fit specific needs. With the development of combinatorial protein engineering and selection techniques, it has become possible to design artificial affinity proteins with the desired properties. These proteins, termed alternative scaffold proteins, are most often chosen for their stability, ease of engineering and cost-efficient recombinant production in bacteria. In this review, we focus on alternative scaffold proteins for which immunoglobulin binders have been identified and characterized.
Regulation of virulence determinants in vitro and in vivo in<i>Staphylococcus aureus</i> (2003)

Staphylococcus aureus is an opportunistic pathogen. In response to changing host environments, this bacterium has the capability to switch on selective sets of genes to enhance its chances for survival. This switching process is precisely controlled by global regulatory elements. There are two major groups of global regulatory elements in S. aureus, including two-component regulatory systems (TCRSs) and the SarA protein family. Presumably, the sensor proteins of the 16 TCRSs in S. aureus provide external sensing, while the response regulators, in conjunction with alternative transcription factors and the SarA protein family, function as effectors within the intricate regulatory network to respond to environmental stimuli. Sequence alignment and structural data indicate that the SarA protein family could be subdivided into three subfamilies: (1) single-domain proteins; (2) double-domain proteins; and (3) proteins homologous to the MarR protein family. Recent data using reporter gene fusions in animal models, have confirmed distinct expression profiles of selected regulatory and target genes in vitro vs. in vivo.
Modulation of CRTh2 expression on allergen‐specific T cells following peptide immunotherapy (2019)

Peptide immunotherapy with Cat-PAD does not significantly alter the frequency or phenotype of Fel d 1-CD4<sup>+</sup> T cells, but may decrease their expression of CRTh2.
Role of Sp Proteins in Regulation of Vascular Endothelial Growth Factor Expression and Proliferation of Pancreatic Cancer Cells (2004)

Sp proteins play an important role in angiogenesis and growth of cancer cells, and specificity protein 1 (Sp1) has been linked to vascular endothelial growth factor (VEGF) expression in pancreatic cancer cells. RNA interference was used to investigate the role of Sp family proteins on regulation of VEGF expression and proliferation of Panc-1 pancreatic cancer cells. Using a series of constructs containing VEGF promoter inserts, it was initially shown that Sp1 and Sp3 were required for transactivation, and this was primarily dependent on proximal GC-rich motifs. We also showed that Sp4 was expressed in Panc-1 cells, and RNA interference assays suggested that Sp4 cooperatively interacted with Sp1 and Sp3 to activate VEGF promoter constructs in these cells. However, the relative contributions of Sp proteins to VEGF expression were variable among different pancreatic cancer cell lines. Small inhibitory RNAs for Sp3, but not Sp1 or Sp4, inhibited phosphorylation of retinoblastoma protein, blocked G0/G1-->S-phase progression, and up-regulated p27 protein/promoter activity of Panc-1 cells; similar results were observed in other pancreatic cancer cells, suggesting that Sp3-dependent growth of pancreatic cancer cells is caused by inhibition of p27 expression.
<i>10 Common Questions About</i> Cryptosporidium (1998)

This article answers 10 commonly asked questions about Cryptosporidium.
Condition based maintenance of PE/XLPE-insulated medium voltage cable networks-verification of the IRC-analysis to determine the cable age (2003)

For a preventive maintenance and a more economical operation of polymer insulated cable networks a destruction free estimation of the status of laid PE/XLPE-cables is a basic need. This contribution presents a condition based maintenance concept with the IRC-Analysis applied on a part of the 20 kV-cable network of a major German utility. With this concept the distributor was able to reduce the amount of insulation failures-especially for cables manufactured before 1984. The general tendency of increasing faults was broken and a higher quality of energy supply was achieved.
ON THE INTERACTIVE TECHNOLOGY IN AIR COMBAT SIMULATION (2000)

A Multi-Aircraft Multi-Target Beyond Visual Range Air Combat (MMBVRAC) Real-Time Simulation System (RISS) is proposed. Interactive technology, the key to the design of MMBVRAC-RISS is discussed in detail. To solve the interactive problem, this paper proposes the data through exchange technology and relay exchange technology, which is quite fit for the MMBVRAC simulation. Meanwhile, to meet the synchronization need, the immediate synchronization technology and synchronization technology are adopted and shown schematically in Fig. 1. There is a new concept, real-time interactive simulation in network, tactics analysis on node, which means a pilot is able not only to take part in the whole MMBVRAC simulation, but also to evaluate strategy and tactics conveniently and independently after the simulation. The design philosophy of independent tactics analysis on node is quite distinctive in that Step Stamp technology is used, whereas Time Stamp or Absolute Time Stamp plays this role in the existing products. At last, the new concept and key technologies presented in this paper are verified by implementation of typical MMBVRAC simulation examples.-=
Chapter 10: Mid-Miocene volcanic and plutonic rocks in the Lake Mead area of Nevada and Arizona; Production of intermediate igneous rocks in an extensional environment (1990)

Middle Tertiary volcanic rocks of the Lake Mead field are calc-alkalic to alkalic-calcic and vary continuously in composition from basalt to rhyolite. These volcanic rocks formed during Basin-and-Range extension and are spatially and genetically associated with diorite-to-granite intrusions of the Wilson Ridge pluton. Locally, igneous rocks were subjected to potassium metasomatism.
Two neoplastic cell lines with unique features derived from Hodgkin's disease (1980)

Two in vitro cell lines (L428, L439) were established from pleural effusions of two patients with Hodgkin's disease. The histological diagnosis was ascertained in both cases by two independent pathologists. The neoplastic nature of the culture cells is indicated by the demonstration of several structural and numerical chromosome abnormalities associated with a monoclonal pattern of marker chromosomes. Heterotransplantation in nude mice was achieved by intracranial inoculation and by subcutaneous transplantation of cultured cells embedded in a plasma clot. EBV-specific antigens (EBNA, VCA) were not detectable in either cell line. Ia-like antigens, receptors for T cells, acid phosphatase and acid esterase were shown to be present in the cultured cells. The L428 and L439 cell line lacked surface- or cytoplasmic Ig, HTLA, receptors for C3b, C3d, IgG-Fc, mouse E or sheep E, and were devoid of lysozyme, peroxidase and chloracetate esterase. These features do not correspond to those of B cells, T cells, myeloid cells, monocytes or macrophages; the morphology and the marker pattern of the culture cells, however, is identical with that of freshly obtained Hodgkin (H)- and Sternberg-Reed (SR)- cells, except for the lack of Clg in the in vitro cells, which is explained by the culture conditions. These findings suggest that the L428 and L439 cell lines are indeed derived from H- and SR-cells and offer the possibility of gaining new information upon the nature of Hodgkin's disease.
Pricing Public Parks (2003)

Admission prices are typically charged for entry to archaeological sites, museums and historic buildings, although rarely to public parks. This study explores the feasibility of introducing an entry charge to a public park in Naples, the Bosco di Capodimonte. It investigates different pricing options: a revenue-maximizing price, a discriminatory price to deal with equity, a 'sufficing' price to cover maintenance costs and a welfare economic social optimal price. The analysis documents the effect of different entry charges on visit numbers and revenue collected, and includes a cost-benefit analysis of the admission price policy. Total consumer surplus is also calculated for the different entry price scenarios.
New Carbazole−Oxadiazole Dyads for Electroluminescent Devices:  Influence of Acceptor Substituents on Luminescent and Thermal Properties (2004)

A series of carbazole−oxadiazole dyads linked by amino functionality is prepared in good yields by C−N coupling reactions catalyzed by Pd(dba)2/P(t-Bu)3 under basic conditions in toluene. The compounds possess additional electron-withdrawing groups such as CF3 and CN either on oxadiazole or on carbazole nucleus. The placement of CF3 on the oxadiazole end enhances the electron deficiency of the oxadiazole unit, while the CN substituent at the carbazole nucleus decreases the donor strength of carbazole. This results in slight alterations in the oxidation potentials and thermal properties of the resulting dyads. This also leads to a pathway for fine-tuning the energy levels and amorphous morphology in these dyads. While CN groups alter by ∼0.2 eV the energy levels, a counterproductive Tg reduction/thermal instability is observed for the CF3 derivatives. All of these derivatives display solvent-dependent emission profiles with the solid-state emission occurring in the cyan region. Electroluminescent devices fabricated using these compounds as hole-transporting layer and Alq3 or TPBI as the electron-transporting layer emit cyan color. The emission in most cases arises from the HTL layer. However, slight distortions in shape and peak position of the EL spectra were noticed, which were attributed to either the mixing of emissions from HTL and ETL layer or the complex formation between the HTL and ETL materials. Energetics governing the confinement of excitons in the emissive layer is critically analyzed.
A Non-invasive Methodology for Fetal Monitoring during Pregnancy (2009)

The novel non-invasive proposed methodology is advantageous since it offers automated identification of fHR and fECG and automated ST waveform analysis, exhibiting a high diagnostic accuracy.
Explicit Congestion Notification (ECN) for RTP over UDP (2012)

This memo specifies how Explicit Congestion Notification (ECN) can be\n used with the Real-time Transport Protocol (RTP) running over UDP,\n using the RTP Control Protocol (RTCP) as a feedback mechanism. It\n defines a new RTCP Extended Report (XR) block for periodic ECN\n feedback, a new RTCP transport feedback message for timely reporting\n of congestion events, and a Session Traversal Utilities for NAT\n (STUN) extension used in the optional initialisation method using\n Interactive Connectivity Establishment (ICE). Signalling and\n procedures for negotiation of capabilities and initialisation methods\n are also defined.