gebhart/patrepeval huggingface dataset:
Characterization of Klotho/FGF23 signaling in cardiorenal syndrome‐induced cardiac hypertrophy (2019)

Introduction In diseases that generate an inflammatory situation, such as cardiorenal syndrome, different clinical conditions promote cardiac and renal dysfunction. There are type 3 and 4 which are characterized by renal insults that subject the heart to dysfunctions; Among the changes that renal injury can lead, we can mention the modulation in Klotho levels, a gene that is negatively regulated by fibroblast growth factor 23 (FGF23). The objective of this study is to evaluate the participation of this axis in cardiac hypertrophy induced by renal ischemia Methods C57BL/6 male mice were subjected to surgical occlusion of left renal pedicle for 60 min followed by reperfusion in acute term (24, 48 and 72h), short term (for 8 and 15 days) and long term (4,6 and 8 weeks). Total heart RNA was extracted for gene expression of Klotho, FGF23 and hypertrophy markers using real‐time PCR. Results The renal injury was confirmed by decreasing of left kidney weight and urea/creatinine levels starting at the 15 th day of reperfusion. Cardiac hypertrophy was confirmed by increased a‐actin levels at day 15 and 4 weeks of renal reperfusion; however, heart weight has maintained increased until the 8 th week of reperfusion. Concerning the FGF23/Klotho axis, both genes were modulated during the cardiorenal syndrome type 3. FGF23 gene expression was mostly increased in heart tissue after 8 days of reperfusion, having its peak during the 4 th week. In renal tissue, FGF23 did not present a pattern, although it shows a peak in the first 24 hours, in the 8 th day and 15 th day (the same timepoints which the heart tissue is affect which electrophysiological and immunological changes). By the other side, Klotho gene expression was mostly reduced in renal tissue after 48h of reperfusion, evidencing even more the renal injury (once some authors consider Klotho is a renal injury biomarker). In heart tissue, klotho expression is reduced since the first 24h, but this is attenuated around the 4 th week of reperfusion. Conclusion We found that cardiac FGF23/Klotho axis dynamics are affected by renal I/R indicating a possible interaction between these two responses during cardiorenal syndrome. Support or Funding Information Financial Support: FAPESP 2015/19107‐5 and 2018/03089‐6. This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .
Quantitative evaluation of approximate frequent pattern mining algorithms (2008)

Traditional association mining algorithms use a strict definition of support that requires every item in a frequent itemset to occur in each supporting transaction. In real-life datasets, this limits the recovery of frequent itemset patterns as they are fragmented due to random noise and other errors in the data. Hence, a number of methods have been proposed recently to discover approximate frequent itemsets in the presence of noise. These algorithms use a relaxed definition of support and additional parameters, such as row and column error thresholds to allow some degree of "error" in the discovered patterns. Though these algorithms have been shown to be successful in finding the approximate frequent itemsets, a systematic and quantitative approach to evaluate them has been lacking. In this paper, we propose a comprehensive evaluation framework to compare different approximate frequent pattern mining algorithms. The key idea is to select the optimal parameters for each algorithm on a given dataset and use the itemsets generated with these optimal parameters in order to compare different algorithms. We also propose simple variations of some of the existing algorithms by introducing an additional post-processing step. Subsequently, we have applied our proposed evaluation framework to a wide variety of synthetic datasets with varying amounts of noise and a real dataset to compare existing and our proposed variations of the approximate pattern mining algorithms. Source code and the datasets used in this study are made publicly available.
Authentication of moving kNN queries (2011)

A moving kNN query continuously reports the k nearest neighbors of a moving query point. In addition to the query result, a service provider that evaluates moving queries often returns mobile clients a safe region that bounds the validity of query results to minimize the communication cost between the two parties. However, when a service provider is not trustworthy, it may send inaccurate query results or incorrect safe regions to clients. In this paper, we present a framework and algorithms to authenticate results and safe regions of moving kNN queries. Extensive experiments on both real and synthetic datasets show that our methods are efficient in terms of both computation time and communication costs.
A novel network architecture for train-to-wayside communication with quality of service over heterogeneous wireless networks (2012)

In the railway industry, there are nowadays different actors who would like to send or receive data from the wayside to an onboard device or vice versa. These actors are e.g., the Train Operation Company, the Train Constructing Company, a Content Provider, etc. This requires a communication module on each train and at the wayside. These modules interact with each other over heterogeneous wireless links. This system is referred to as the Train-to-Wayside Communication System (TWCS). While there are already a lot of deployments using a TWCS, the implementation of quality of service, performance enhancing proxies (PEP) and the network mobility functions have not yet been fully integrated in TWCS systems. Therefore, we propose a novel and modular IPv6-enabled TWCS architecture in this article. It jointly tackles these functions and considers their mutual dependencies and relationships. DiffServ is used to differentiate between service classes and priorities. Virtual local area networks are used to differentiate between different service level agreements. In the PEP, we propose to use a distributed TCP accelerator to optimize bandwidth usage. Concerning network mobility, we propose to use the SCTP protocol (with Dynamic Address Reconfiguration and PR-SCTP extensions) to create a tunnel per wireless link, in order to support the reliable transmission of data between the accelerators. We have analyzed different design choices, pinpointed the main implementation challenges and identified candidate solutions for the different modules in the TWCS system. As such, we present an elaborated framework that can be used for prototyping a fully featured TWCS.
Improved scatterometry time to solution for leading-edge logic applications (2010)

This paper describes an innovative approach to scatterometry modeling, significantly reducing time to solution compared to the industry's current best practices. One of the drawbacks to traditional scatterometry measurement techniques is the time required to optimize the model, which includes material optical constant extraction, model build time, initial model optimization, and model testing. A novel methodology that includes both stability and self-consistent scatterometry accuracy prediction can achieve an order of magnitude gain in productivity over prior methods. This technique creates opportunities among semiconductor chip manufacturers for wider scatterometry adoption at advanced technology nodes, where scatterometry is often the only reliable non-destructive metrology for device structure dimensions. The reductions in cycle time and improvements in accuracy prediction are keys to the success of scatterometry as an enabler for advanced process control and monitoring. This paper presents results on a conventional poly gate litho and final inspection and on leading-edge high-k metal gate after-etch applications. Spectroscopic ellipsometry is used to collect spectra from the gratings on the wafers. Then scatterometry results are obtained using the new approach and via traditional industry-accepted procedures to compare time to solution. To confirm the validity of the results, reference metrology data are collected on a CDSEM and TEM and the total measurement uncertainty is evaluated.
HOMOLOGY AND HOMOTOPY OF H-SPACES (1960)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
Correction: Measuring the Strength of Interaction between the Ebola Fusion Peptide and Lipid Rafts: Implications for Membrane Fusion and Virus Infection (2011)

The Ebola fusion peptide (EBO 16 ) is a hydrophobic domain that belongs to the GP2 membrane fusion protein of the Ebola virus. It adopts a helical structure in the presence of mimetic membranes that is stabilized by the presence of an aromaticaromatic interaction established by Trp8 and Phe12. In spite of its infectious cycle becoming better understood recently, several steps still remain unclear, a lacuna that makes it difficult to develop strategies to block infection. In order to gain insight into the mechanism of membrane fusion, we probed the structure, function and energetics of EBO 16 and its mutant W8A, in the absence or presence of different lipid membranes, including isolated domain-resistant membranes (DRM), a good experimental model for lipid rafts. The depletion of cholesterol from living mammalian cells reduced the ability of EBO 16 to induce lipid mixing. On the other hand, EBO 16 was structurally sensitive to interaction with lipid rafts (DRMs), but the same was not observed for W8A mutant. In agreement with these data, W8A showed a poor ability to promote membrane aggregation in comparison to EBO 16 . Single molecule AFM experiments showed a high affinity force pattern for the interaction of EBO 16 and DRM, which seems to be a complex energetic event as observed by the calorimetric profile. Our study is the first to show a strong correlation between the initial step of Ebola virus infection and cholesterol, thus providing a rationale for Ebola virus proteins being co-localized with lipid-raft domains. In all, the results show how small fusion peptide sequences have evolved to adopt highly specific and strong interactions with membrane domains. Such features suggest these processes are excellent targets for therapeutic and vaccine approaches to viral diseases.
Functionally grading the shape memory response in NiTi films: Laser irradiation (2009)

A new process and mechanism are presented for controlling the shape memory response spatially within monolithic NiTi thin film structures. This technique is shown to effectively control the martensitic phase transformation temperature and exhibits control over aspects of the mechanical and shape memory responses as well. Specifically, the martensitic phase transformation temperature decreases with incident laser energy density. Concomitant modifications are observed in both the mechanical and shape memory responses in laser processed films. Analysis and characterization are performed via temperature controlled optical microscopy, x-ray diffraction, atomic force microscopy, and nanoindentation.
Phenolic Components of Olive Mill Waste-Waters (2000)

Abstract Two new aromatic compounds have been isolated from the reverse osmosis fraction of the olive mill waste-waters and identified as C6-C2 dimers on the basis of their physical features. Key Words: olive mill waste-watersultrafiltrationreverse osmosisphenols
The prevalence of retinopathy in an unselected population of type 2 diabetes patients from Århus County, Denmark (2004)

The prevalence of diabetic retinopathy and visual impairment in this unselected type 2 diabetes population was lower than anticipated from the existing literature, and causes other than diabetic retinopathy contributed significantly to the occurrence of visual loss. A substantial number of the patients with vision-threatening diabetic maculopathy had not been referred for timely photocoagulation treatment.
Hartley Spectral Pooling for Deep Learning (2018)

In most convolution neural networks (CNNs), downsampling hidden layers is adopted for increasing computation efficiency and the receptive field size. Such operation is commonly so-called pooling. Maximation and averaging over sliding windows (max/average pooling), and plain downsampling in the form of strided convolution are popular pooling methods. Since the pooling is a lossy procedure, a motivation of our work is to design a new pooling approach for less lossy in the dimensionality reduction. Inspired by the Fourier spectral pooling(FSP) proposed by Rippel et. al. [1], we present the Hartley transform based spectral pooling method in CNNs. Compared with FSP, the proposed spectral pooling avoids the use of complex arithmetic for frequency representation and reduces the computation. Spectral pooling preserves more structure features for network's discriminability than max and average pooling. We empirically show that Hartley spectral pooling gives rise to the convergence of training CNNs on MNIST and CIFAR-10 datasets.
한국형사법학회 형사소송법 개정안에 대한 논평 (2011)

이 논문은 한국형사법학회의 형사소송법 개정특별위원회가 마련한 형사소송법 개정안 중 수사 일반과 강제처분 부분에 대한 간략한 논평을 그 내용으로 하여 한국형사법학회 2010년 동계학술회의에서 발표한 발표문을 수정, 보완한 것이다. 연구회 개정안은 2007년 형사소송법 개정 당시 검토과제에 포함되지 않았던 문제들을 주로 다루고 있다. 예컨대 수사 일반에서 ①...
SOMATOSTATIN INDUCES HISTAMINE SECRETION FROM RAT PERITONEAL MAST CELLS1 (1978)

Cyclic somatostatin strongly stimulated secretion of histamine from rat peritoneal mast cells. The energy, temperature and calcium dependence of this effect indicate that the action of somatostatin on the mast cells is similar to that of the classic mast cell secretagogue compound 48/80 and is to induce exocytosis.
Optimization of a Yellow Fluorescent Protein-Based Iodide Influx High-Throughput Screening Assay for Cystic Fibrosis Transmembrane Conductance Regulator ( <i>CFTR</i> ) Modulators (2010)

Cystic fibrosis is an inherited, life-threatening disease associated with mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The most common mutation, F508del CFTR, is found in 90% of CF patients. The loss of a single amino acid (phenylalanine at position 508) results in malformed CFTR with defective trafficking to the plasma membrane and impaired channel function. A functional assay with cells expressing F508del CFTR has been previously described by others using genetically engineered halide-sensitive yellow fluorescent protein to screen for CFTR modulators. We adapted this yellow fluorescent protein assay to 384-well plate format with a high-throughput screening plate reader, and optimized the assay in terms of data quality, resolution, and throughput, with target-specific protocols. The optimized assay was validated with reference compounds from cystic fibrosis foundation therapeutics. On the basis of the Z-factor range (≥0.5) and the potential productivity, this assay is well suited for high-throughput screening. It was successfully used to screen for active single agent and synergistic combinations of single agent modulators of F508del CFTR from a library collection of current active pharmaceutical ingredients (supported by Cystic Fibrosis Foundation Therapeutics).
Optomyography - Detection ofmuscle surface displacement using reflective photo resistor. (2014)

A human body can carry out many physiological complex processes which can be mechanical, electrical or bio-chemical. Each mechanical activity generates a signal that describes the characteristics of the particular action in the form of pressure or temperature. Any irregularity in the process changes the usual functioning thus affecting the performance of the system. Several techniques were introduced to evaluate these muscular signals in order to get a deeper understanding of the medical abnormalities. Displacement sensors, laser optics, electrodes, accelerometers and microphones are some of the widely used devices in measuring the electrical and mechanical activities produced in the muscles. The aim of this thesis project was to find and implement a simple non-contact optical method to measure and monitor the displacements caused on the surface of the skin due to muscular movements. In this study, a device was developed using photo electric sensors that can record surface changes caused on the skin due to the movements forearm muscles.
Lipid-Derived Aroma Compounds in Cooked Potatoes and Reconstituted Dehydrated Potato Granules (1994)

Volatile compounds that contribute to flavor of steam cooked mashed potatoes and reconstituted dehydrated potato granules were characterized. Aroma components were isolated and concentrated using continuous steam distillation - extraction procedures and/or by dynamic headspace concentration using porous polymer adsorbent trapping media. The steam distillation extracts and adsorbent traps were subsequently analyzed by gas chromatography - mass spectrometry (GC-MS), the latter using short path thermal desorption methodology. Quantification was achieved using matrix-spiked internal standard methodology. Comparison of the two isolation techniques revealed both qualitative and quantitative differences in the extracted profiles which were highly reproducible. The purge and trap - thermal desorption methodology produced GC-MS chromatograms with enhanced recoveries of light end components while the steam distillation extracts contained greater amounts of higher boiling semivolatile species.
Long-term field performance of a polyester-based long-lasting insecticidal mosquito net in rural Uganda (2008)

Second generation PermaNet showed excellent results after three years of field use and fulfilled the WHOPES criteria for LLIN. Loss of insecticide on LLIN using coating technology under field conditions was far more influenced by factors associated with handling rather than washing.
Software management based on mobile agents (2007)

There is a need for better management of company's software. It means global access control and hierarchical version control for all the software, used in a project environment. This management involves control of the software reuse even if it is free access software. The directives, we present in this document are designed to set traceability of used software from the project creation until its last evolution. Because this kind of information belongs to the project itself, it has to be saved closely to the core data of the project. A software management directive improves the quality of the project and insures a better maintainability. Our management system is based on mobile agent system. The agents observe the use and context of any software. Such mobile agent system is able to create reports about the activities of the software but also, the agent collect data, which will be the basis of a software map of the company. It will also increase the opportunity for software reuse and consequent productivity improvements.
Load modelling and simulation of household electricity consumption for the evaluation of demand-side management strategies (2013)

In order to evaluate the effectiveness of demand-side management techniques, mechanisms to simulate electricity consumption activities at a granular level are required. A bottom-up approach that uses a non-homogeneous Markov chain to model each appliance within each household is proposed. This model is time-aware and captures the variability of the transition probabilities as they change throughout the day. A simulator was developed based on this model and it was configured with data obtained from a household electricity survey conducted in the UK. The resultant load curves from a simulation of a thousand households are compared with the average hourly load reported in the survey, with significant similarities observed between the two. The same model can be parametrised to simulate hypothetical scenarios, such as a future where electric vehicles are more popular. The simulation framework also supports a plug-in mechanism through which demand control policies can be integrated into the system such that the effects and performance of demand-side management strategies can be evaluated.
Measurement of elongation viscosity for polymer melts by fiber spinning (1997)

The elongation behavior of various polymer melts extruded from the single screw extruder has been studied. Low-density polyethylene, high-density polyethylene, polypropylene, and their short glass-fiber (GF)-filled composites were used. It was found that the spinning stability was good but the drawability was poor for GF-filled polymers. The elongation viscosity was measured by use of a Gottfert tensiometer (Rheotens) in the strain rate range from 0.1 to 4 s−1. In regard to the viscosity calculations, a very convenient and straightforward method, especially for molten materials without die swell, is presented. All the sample melts showed slight tension thinning; that is, the elongation viscosity decreased along with the strain rate. It was also found that the elongation viscosity of the GF-filled polymer may increase along with the fiber content up to a critical value, and then drop if more fiber is added. The influence of the die geometry on the viscosity measurement is discussed. © 1997 John Wiley & Sons, Inc. Adv in Polym Techn 16: 199–207, 1997
Environmental stress cracking resistance of blow moded poly(ethylene terephthalate) containers (1992)

Abstract A method is developed for determining the environmental stress cracking resistance (ESCR) of blow molded poly(ethylene terephthalate) (PET) containers. By this method, the internal chamber of a container is presurized in 68.9 kPa (10 psi) increments while the outside of the base is being exposed to an environmental stress cracking (ESC) agent. The base of the container is examined after each 68.9 kPa of pressurization if crazing has occurred. The process is continued until a threshold value of craze initiation pressure (CIP) can be determined. Low CIP for the type of containers tested generally corresponds to a high rate of field failures. The method does not only gage the susceptibility of different types of one‐piece PET containers to ESC but also provides helpful information to improve the container designs.
Image sequence interpolation for improving the resolution of the magnified image (2002)

In the present paper we propose an image sequence interpolation algorithm for improving the resolution of the magnified image. The proposed algorithm can be divided by two parts. The first main processing part is to overcome the limits of existing still image interpolation by using image sequences and is composed of motion estimation, image registration, and image interpolation. The second post processing part is to remove the artifacts in the interpolated image due to main processing by a directionally adaptive filtering. It is demonstrated that the proposed algorithm can be the theoretical bases for interpolation of dynamic image sequences, and experimental results of the proposed algorithm are also presented.
Pyrone series. Part IX. Some reactions of 1-amino-4,5,6-triaryl-2-pyridones (1969)

Six-membered copper bis-(1-salicylideneamino-4,5,6-triaryl-2-pyridone) complexes and a number of 1-arylidene-amino-, 1-phthalimido-, 1-succinimido-, and 1-maleimido-4,5,6-triaryl-2-pyridones have been prepared. Of these, the 1-arylideneamino-derivatives are not hydrolysed by hydrochloric acid, but copper chloride or 2,4-dinitrophenylhydrazine catalyses the formation of the free amine and the corresponding aldehyde.