gebhart/patrepeval huggingface dataset:
Protective effects of juzentaihoto, dried decoctum of 10 chinese herbs mixture, upon the adverse effects of mitomycin C in mice. (1983)

In view of the reduction of side effects as well as the enhancement of anti-tumor activities of anticancer drugs, we have been interested in the combined use of Chinese medicines with them. In the present study, we attempted to examine the effects of Chinese prescription, juzentaihoto (JTX), combined with mitomycin C (MMC). JTX is consisted of Astragali radix, Chinnamomi cortex, Rehmanniae radix, Paeonia radix, Cnidii rhizoma, Atractylodis lanceae rhizoma, Angelicae radix, Ginseng radix, Hoelen and Glycyrrhizae radix. In BDF1-mice which were implanted with P-388 leukemic cells, JTX prolonged significantly the average survival days of MMC-treated group. In tumor-free BDF1-mice, JTX improved the leukopenia and the body weight loss which were caused by MMC. Additionally, JTX delayed the appearance of deaths by lethal dosis of MMC. These results indicate that JTX enhances the anti-tumor activity of MMC and lessens the adverse effects of it. JTX may be useful for patients undertaking MMC treatment.
How to design a system in which modules can be changed on the fly (1976)

In a system made up of many modules, each managing its own peculiar types of data structures, it is often necessary to update one of the modules so as to provide new features or an improvement in the internal organization. If the interface to the module is unchanged or merely augmented the programs which interact with the module need not be changed. If the system can be brought to an orderly halt and if the module does not manage permanent data structures, it will merely be necessary to recompile the modified module, relink the system, stop the old system, and install the new one. If the module does manage permanent data structures which must be modified and the system is one which is expected to continue operation throughout the change, the problem is more difficult, but it can be solved. This paper discusses a solution.
Hope Springs Eternal from Mary (2010)

promising assay results from recent drilling at Mary Springs makes Ethan Minerals Limited confident that its Mary Springs project will become a mine again. It is working on delineating a deposit and re-establishing a mining centre within the Northampton mineral belt in its efforts to move from explorer to miner.
Experimental Study of Hybrid Anti-Icing Systems Combining Thermoelectric and Hydrophobic Coatings (2011)

<div class="section abstract"><div class="htmlview paragraph">Two commercial hydrophobic coatings: StaClean™ with a water droplet contact angle of 101° and Wearlon® Super F1-Ice with a contact angle of 115° and one superhydrophobic coating: HIREC 1450 with a contact angle of 152° were studied combined with a thermoelectric anti-icing system under icing conditions. All coatings and the reference surface were tested under glaze and rime ice. The deicing tests were conducted in the Anti-icing Materials International Laboratory's (AMIL) low speed closed loop Icing Wind Tunnel with 0.4 g/m₃ liquid water content, a 26.7 ± 2.6 μm water droplet median volumetric diameter, 21 ± 0.5 m/s air speed and temperatures of -5 and -20 ± 0.5°C. For these tests, a 4\mi chord NACA 63-415 airfoil 2D blade box-section of 10\mi covered with a thin aluminum sheet protected at the leading edge and on the bottom by a thermoelectric anti-icing system composed of two 1/2\mi x 10\mi heating elements with a power density of 40 W/in₂, was used. The superhydrophobic coating showed excellent results with a power reduction of 13% for rime ice and 33% for glaze ice. Hydrophobic coatings performed at a lower level than the superhydrophobic coatings with a power reduction of about 8% for rime ice and 13% for glaze ice, but their effect was still significant. Also, the coatings significantly improved the runback water, most probably due to their hydrophobic nature. For the superhydrophobic coating, the surface was mostly free of ice due to the fact that drops roll over the surface to the trailing edge and for hydrophobic coatings, the runback back water froze outside the protected area; with time, a barrier developed which stopped runback water and ice accumulation increased with time. For rime and glaze ice accretion, the higher the contact angle, the more effective the coating; which suggests that a superhydrophobic surface with a high contact angle could significantly reduce the anti-icing power required.</div></div>
The Glycosyltransferase Involved in Thurandacin Biosynthesis Catalyzes Both O- and S-Glycosylation (2013)

The S-glycosyltransferase SunS is a recently discovered enzyme that selectively catalyzes the conjugation of carbohydrates to the cysteine thiol of proteins. This study reports the discovery of a second S-glycosyltransferase, ThuS, and shows that ThuS catalyzes both S-glycosylation of the thiol of cysteine and O-glycosylation of the hydroxyl group of serine in peptide substrates. ThuS-catalyzed S-glycosylation is more efficient than O-glycosylation, and the enzyme demonstrates high tolerance with respect to both nucleotide sugars and peptide substrates. The biosynthesis of the putative products of the thuS gene cluster was reconstituted in vitro, and the resulting S-glycosylated peptides thurandacin A and B exhibit highly selective antimicrobial activity toward Bacillus thuringiensis.
Isolation and Characterization of the 5′-Upstream Region of the Human N-type Calcium Channel α1B Subunit Gene (1997)

omega-Conotoxin-sensitive N-type Ca2+ channels, unlike dihydropyridine-sensitive L-type channels, are exclusively expressed in nervous tissues. To understand the molecular basis for neuron-specific expression of the N-type channel, we have isolated genomic clones encoding the human alpha1B subunit gene, localized to the long arm of chromosome 9 (9q34) by fluorescence in situ hybridization, and characterized its 5'-upstream region. The proximal promoter of the alpha1B subunit gene lacks a typical TATA box, is highly GC-rich, and contains several sequences for transcription factor binding. Primer extension experiments revealed the presence of two transcription start sites. In vitro transfection study of the alpha1B subunit-luciferase fusion gene showed that the 4.0-kb 5'-flanking region of the alpha1B gene functions as an efficient promoter in neuronal cells but not in glioma or nonneuronal cells, consistent with the patterns of the endogenous alpha1B gene expression in these cells. Deletion analysis of alpha1B subunit-luciferase fusion gene constructs further revealed the presence of several cis-acting regulatory elements, including a potential repressor located in the distal upstream region (-3992 to -1788) that may be important for the neuron-specific expression of the N-type Ca2+ channel alpha1B subunit gene.
Metal-Resistant Fluid Cracking Catalysts (1991)

Although the deleterious effects of metals such as V, Cu, Ni and Fe have been known for well over forty years (1-19), the study of metal resistant fluidized cracking catalysts (FCC) became an area of intense research in industrial and academic laboratories only in the early seventies when the Arab Oil embargo induced nearly a four-fold increase in crude prices and greatly reduced overseas crude availability (2). Metal levels (Ni+V) on equilibrium catalysts from U.S. refineries have been monotonically increasing with time since the early sixties (20). This trend continued during the 1980-1986 period (Figure 1) when crude prices decreased to about $25/bbl from $38/bbl, Figure 2. Following the 1986 oil price collapse (crudes sold for $9.35/bbl in August 1986), V level started to decrease somewhat, probably because of the refiners selection of more paraffinic crudes. However, Ni levels on equilibrium catalysts has remained unchanged. Thus, the importance of processing metals contaminated feeds has not significantly changed through the years and it has been projected that by 1995, 25% to 30% of the world's FCC units will be partially operating as resid crackers (21). It is the purpose of this paper to review the progress made in understanding and designing zeolite-containing fluidized cracking catalysts capable of negating the deleterious effects of metals such as nickel and vanadium.
Multiple myeloma: 2016 update on diagnosis, risk‐stratification, and management (2016)

Multiple myeloma accounts for approximately 10% of hematologic malignancies.The diagnosis requires ≥10% clonal bone marrow plasma cells or a biopsy proven plasmacytoma plus evidence of one or more multiple myeloma defining events (MDE): CRAB (hypercalcemia, renal failure, anemia, or lytic bone lesions) features felt related to the plasma cell disorder, bone marrow clonal plasmacytosis ≥60%, serum involved/uninvolved free light chain (FLC) ratio ≥100 (provided involved FLC is ≥100 mg/L), or >1 focal lesion on magnetic resonance imaging. Patients with del(17p), t(14;16), and t(14;20) have high-risk multiple myeloma. Patients with t(4;14) translocation and gain(1q) have intermediate-risk. All others are considered standard-risk. Initial treatment consists of bortezomib, lenalidomide, dexamethasone (VRD). In high-risk patients, carfilzomib, lenalidomide, dexamethasone (KRD) is an alternative to VRD. In eligible patients, initial therapy is given for approximately 3-4 months followed by autologous stem cell transplantation (ASCT). Standard risk patients can opt for delayed ASCT at first relapse. Patients not candidates for transplant are treated with Rd until progression, or alternatively, a triplet regimen such as VRD for approximately 12-18 months. After ASCT, lenalidomide maintenance is considered for standard risk patients especially in those who are not in very good partial response or better, while maintenance with a bortezomib-based regimen is needed for patients with intermediate or high-risk disease. Patients with indolent relapse can be treated with 2-drug or 3-drug combinations. Patients with more aggressive relapse require a triplet regimen or a combination of multiple active agents. Am. J. Hematol. 91:720-734, 2016. © 2016 Wiley Periodicals, Inc.
Multiplexed Immunoassay Panel Identifies Novel CSF Biomarkers for Alzheimer's Disease Diagnosis and Prognosis (2011)

Background: Clinicopathological studies suggest that Alzheimer's disease (AD) pathology begins ,10-15 years before the resulting cognitive impairment draws medical attention. Biomarkers that can detect AD pathology in its early stages and predict dementia onset would, therefore, be invaluable for patient care and efficient clinical trial design. We utilized a targeted proteomics approach to discover novel cerebrospinal fluid (CSF) biomarkers that can augment the diagnostic and prognostic accuracy of current leading CSF biomarkers (Ab42, tau, p-tau181).
유아교사의 자기결정성과 창의적 교수행동 관계에 미치는 교수몰입의 매개 효과 연구 (2016)

본 연구는 유아교사를 대상으로 교수몰입이 자기결정성과 창의적 교수행동을 어떻게 매개하는지를 살펴보았다. 이를 위하여 서울, 경기 지역의 유치원과 어린이집에 재직 중인 유아교사 293명을 대상으로 설문조사를 실시하였다. 사용된 설문지는 자기결정성, 교수몰입, 창의적 교수행동에 대한 내용이며, 자료분석은 PASW20.0과 AMOS 18.0을 이용하여 자기결정성, 교수몰입, 창의적 교수행동 간의 상관관계를 검토하고 구조방정식을 이용한 완전매개와 부분매개모형을 비교ㆍ분석하였다. 그 결과, 자기결정성과 창의적 교수행동 간의 관계에서 교수몰입이 완전 매개 역할을 하는 것으로 나타났다. 즉, 유아교사의 창의적 교수행동에 있어 교수몰입의 중요성을 알 수 있었다. 본 연구 결과를 토대로 예비 유아교사와 현직 유아교사의 교수몰입을 향상시킬 수 있는 교사 교육의 필요성을 제시하고 창의적 교수행동을 위한 시사점과 후속연구를 위한 제언을 하였다.
Miscibility and phase separation in poly(vinyl methyl ether)/poly(bisphenol A hydroxy ether) blends (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMiscibility and phase separation in poly(vinyl methyl ether)/poly(bisphenol A hydroxy ether) blendsC. Uriarte, J. I. Eguiazabal, M. Llanos, J. I. Iribarren, and J. J. IruinCite this: Macromolecules 1987, 20, 12, 3038–3042Publication Date (Print):May 1, 1987Publication History Published online1 May 2002Published inissue 1 May 1987https://pubs.acs.org/doi/10.1021/ma00178a016https://doi.org/10.1021/ma00178a016research-articleACS PublicationsRequest reuse permissionsArticle Views93Altmetric-Citations38LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A model-based approach to updating databases with incomplete information (1988)

Suppose one wishes to construct, use, and maintain a database of facts about the real world, even though the state of that world is only partially known. In the artificial intelligence domain, this problem arises when an agent has a base set of beliefs that reflect partial knowledge about the world, and then tries to incorporate new, possibly contradictory knowledge into this set of beliefs. In the database domain, one facet of this situation is the well-known null values problem. We choose to represent such a database as a logical theory, and view the models of the theory as representing possible states of the world that are consistent with all known information. How can new information be incorporated into the database? For example, given the new information that “ b or c is true,” how can one get rid of all outdated information about b and c , add the new information, and yet in the process not disturb any other information in the database? In current-day database management systems, the difficult and tedious burden of determining exactly what to add and remove from the database is placed on the user. The goal of our research was to relieve users of that burden, by equipping the database management system with update algorithms that can automatically determine what to add and remove from the database. Under our approach, new information about the state of the world is input to the database management system as a well-formed formula that the state of the world is now known to satisfy. We have constructed database update algorithms to interpret this update formula and incorporate the new information represented by the formula into the database without further assistance from the user. In this paper we show how to embed the incomplete database and the incoming information in the language of mathematical logic, explain the semantics of our update operators, and discuss the algorithms that implement these operators.
Synthesis of 3-amino-1,2,3,4-tetrahydro-6-hydroxycarbazole, an analogue of 5-hydroxytryptamine (1970)

G. E. A. Coombes, D. J. Harvey and S. T. Reid, J. Chem. Soc. C, 1970, 325 DOI: 10.1039/J39700000325
Pore Size Determination of MCM-51 Mesoporous Materials by means of 1H NMR Spectroscopy, N2 adsorption, and HREM. A Preliminary Study (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPore Size Determination of MCM-51 Mesoporous Materials by means of 1H NMR Spectroscopy, N2 adsorption, and HREM. A Preliminary StudyRalf Schmidt, Eddy Walther Hansen, Michael Stoecker, Duncan Akporiaye, and Ole Henrik EllestadCite this: J. Am. Chem. Soc. 1995, 117, 14, 4049–4056Publication Date (Print):April 1, 1995Publication History Published online1 May 2002Published inissue 1 April 1995https://pubs.acs.org/doi/10.1021/ja00119a021https://doi.org/10.1021/ja00119a021research-articleACS PublicationsRequest reuse permissionsArticle Views2632Altmetric-Citations273LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Saliency-driven unstructured acoustic scene classification using latent perceptual indexing (2009)

Automatic acoustic scene classification of real life, complex and unstructured acoustic scenes is a challenging task as the number of acoustic sources present in the audio stream are unknown and overlapping in time. In this work, we present a novel approach to classification such unstructured acoustic scenes. Motivated by the bottom-up attention model of the human auditory system, salient events of an audio clip are extracted in an unsupervised manner and presented to the classification system. Similar to latent semantic indexing of text documents, the classification system uses unit-document frequency measure to index the clip in a continuous, latent space. This allows for developing a completely class-independent approach to audio classification. Our results on the BBC sound effects library indicates that using the saliency-driven attention selection approach presented in this paper, 17.5% relative improvement can be obtained in frame-based classification and 25% relative improvement can be obtained using the latent audio indexing approach.
Safe disposal of inflammatory monosodium urate monohydrate crystals by differentiated macrophages (2002)

These findings imply that differentiated macrophages provide a safe-disposal mechanism for the removal of inflammatory urate crystals. This may be of clinical relevance to the maintenance of asymptomatic hyperuricemia and the resolution of acute gout.
Kea, Bird of Paradox: The Evolution and Behaviour of a New Zealand Parrot (2000)

"Kea, Bird of Paradox: The Evolution and Behaviour of a New Zealand Parrot." Emu - Austral Ornithology, 100(1), pp. 78–79
Characterization of the Microfluidic Oscillator (2007)

The microfluidic oscillator is a new microscale actuator developed for flow control applications. These patented devices can produce a 325-ytm-wide oscillating gas jet at high frequencies (over 22 kHz) and very low flow rates (∼1 1/ min or ∼1 g/ min). Furthermore, microfluidic oscillators have no moving parts; the jet oscillations depend solely on the internal fluid dynamics. In this work, the flowfield of a microfluidic oscillator is characterized using pressure transducers, water visualization, and pressure-sensitive paint. The acoustic field and frequency spectrum were characterized for the oscillator at several flow rates. The results indicate that the external flowfield of the microfluidic oscillator is marked by two distinct operating regimes, separated by a transitional increase in turbulent noise. This work also demonstrates a significant advance in pressure-sensitive paint technology. New instrumentation was developed to resolve small-scale, time-resolved measurements of a high-frequency micro flowfield. A macro imaging system was used to provide a spatial resolution of approximately 3 mm per pixel and time-resolved, full-unsteady pressure measurements at oscillation frequencies up to 21 kHz.
Complex Hemodynamics at the Apex of an Arterial Bifurcation Induces Vascular Remodeling Resembling Cerebral Aneurysm Initiation (2007)

Strong localization of aneurysm-type remodeling to the region of accelerating flow suggests that a combination of high wall shear stress and a high gradient in wall shear stress represents a "dangerous" hemodynamic condition that predisposes the apical vessel wall to aneurysm formation.
Modulation of matrix metalloproteinase production by rheumatoid arthritis synovial fibroblasts after cadherin 11 engagement (2011)

Cadherin 11 engagement stimulates increased synthesis of several MMPs by RA synovial fibroblasts in a MAPK- and NF-κB-dependent manner. These results underscore the existence of a pathway by which cadherin 11 regulates MMP production and has important implications for joint destruction in RA.
Primary antiphospholipid syndrome: functional outcome after 10 years. (2000)

Functional prognosis is poor in an important minority of primary APS patients with > 10 years of disease. One-third of primary APS patients had organ damage and one-fifth were functionally impaired.
Phenylalanine Stimulation of Gramicidin S Formation (1976)

Bacillus brevis produces the antibiotic gramicidin S, a cyclic peptide comprised of two pentapeptide units of the sequence d -Phe- l -Pro- l -Val- l -Orn- l -Leu. Synthesis of this antibiotic is carried out by two enzymes, GS synthetases I and II. By supplementing a defined minimal medium [glycerol, NH 4 + , tris(hydroxymethyl)aminomethane, salts] with each of the constituent amino acids (in the l form), we found that only l -phenylalanine had a marked stimulatory effect on gramicidin S production. This effect was not caused by an increase in growth, by an induction of GS synthetases I or II, or by a stabilization of these enzymes. l -Phenylalanine apparently stimulates production via its role as a precursor of the d -phenylalanine moiety of the gramicidin S molecule.
The Psychological Aspects of Loneliness Experienced by College Students (1984)

Loneliness is a common problem that occurs at various life stages, but is most intense for college students. To clarify and operationalize the concepts of loneliness, several current sociological and psychological approaches to loneliness were critically examined.\nThe major purposes of this study were to identify the lonely among the student population, the types of loneliness they experience, the behavioral manifestations of that loneliness, and the effectiveness of an intervention method. The Belcher Extended Loneliness Scale as administered to 126 students in a pretest and 203 students in a posttest. The students also answered questions about grade point average and plans to return to Western Michigan University.\nAlthough there was no support for loneliness being reduced as a result of the intervention, statistical analyses revealed that other factors were found to influence the loneliness scores. Students that reported failing grade point averages also reported more loneliness. Males were significantly lonelier, when both gender and living arrangements were considered. Females living in coed residence halls were the least lonely group.\nImplications for interventions based upon validated research findings were discussed. Finally, some major implications and caveats for future empirical studies on loneliness among college students are indicated.