gebhart/patrepeval huggingface dataset:
Social Engagement and Attachment (2003)

This article focuses on the importance of social engagement and the behavioral and neurophysiological mechanisms that allow individuals to reduce psychological and physical distance. A model of social engagement derived from the Polyvagal Theory is presented. The model emphasizes phylogeny as an organizing principle and includes the following points: (1) there are well-defined neural circuits to support social engagement behaviors and the defensive strategies of fight, flight, and freeze; (2) these neural circuits form a phylogenetically organized hierarchy; (3) without being dependent on conscious awareness, the nervous system evaluates risk in the environment and regulates the expression of adaptive behavior to match the neuroception of a safe, dangerous, or life-threatening environment; (4) social engagement behaviors and the benefits of the physiological states associated with social support require a neuroception of safety; (5) social behaviors associated with nursing, reproduction, and the formation of strong pair bonds require immobilization without fear; and (6) immobilization without fear is mediated by a co-opting of the neural circuit regulating defensive freezing behaviors through the involvement of oxytocin, a neuropeptide in mammals involved in the formation of social bonds. The model provides a phylogenetic interpretation of the neural mechanisms mediating the behavioral and physiological features associated with stress and several psychiatric disorders.
Combining context navigation with semantic autocompletion to solve problems in concept selection (2008)

Abstract. Many tasks on the semantic web require the user to choose concepts from a limited vocabulary e.g. for describing an indexed resource or for use in semantic search. Semantic autocompletion interfaces offer an efficient way for concept selection. However, these interfaces usually do not expose the semantic context of the matched concepts, thereby making it hard to know if a matched concept is the right one, as well as hiding possibly more appropriate choices. Ontology browsers, on the other hand, show context but do not allow quick discovery or embedding into other applications. To lessen these problems, we present an interface combining semantic autocompletion with in-place ontological context navigation. Because required context differs between ontologies, the implementation was designed to make it easy to add different contexts and visualizations. To test the applicability of our idea and implementation the system was tested on three ontologies with different requirements and structure. 1
Optical crossconnects of reduced complexity for WDM networks with bidirectional symmetry (1998)

One promising approach to provisioning and restoration in long-haul wavelength-division-multiplexing (WDM) networks is to deploy a mesh of optical crossconnects that operate on individual wavelengths. As wavelength-count and traffic demand rapidly increase, however, this approach will likely require high-port-count optical crossconnects that severely strain the capabilities of known device technologies. Thus, it is critical to devise ways to build large crossconnects from a small number of constituent switches, each with reduced port count. We present a general means of accomplishing this for networks, such as current long-haul networks, that demonstrate bidirectional symmetry. We describe a broad class of symmetry-exploiting architectures that yield N/spl times/N crossconnects, both rearrangeably nonblocking and strictly nonblocking, using constituent switch fabrics no larger than N/2/spl times/N/2. By exploiting connection-symmetry, these architectures reduce the number of such N/2/spl times/N/2 fabrics by 30%-50% compared with corresponding fully connected three-stage Benes and Clos switch structures.
New polyenic antibiotics active against Gram-positive and Gram-negative bacteria. VI. Non-lactonic polyene antibiotic, enacyloxin IIa, inhibits binding of aminoacyl-tRNA to A site of ribosomes. (1992)

Enacyloxin (ENX) Ila is a polyenic antibiotic having a linear structure1* and its antibiotic action is shown to be limited to Gram-positive and Gram-negative bacteria2). Wehave been interested in the mode of action ofENX Ila because it is very unique in its chemical structure. In the preceding paper3), we described that ENX Ila markedly inhibited the incorporation of L-[3H]phenylalanine into TCA-insoluble fractions of both growing cells and cell-free system (S-30 fraction) of Escherichia coll. Fromthese results, the primary site of action of ENXIla seems to be protein synthesis. In this paper, a more detailed mode of action of ENXIla is described.
INHIBITION OF CYCLOOXYGENASE-2 SUPPRESSES ANGIOGENESIS AND THE GROWTH OF PROSTATE CANCER IN VIVO (2000)

Cyclooxygenase (COX)-2, an inducible enzyme which catalyzes the formation of prostaglandins from arachidonic acid, is expressed in prostate cancer specimens and cell lines. To evaluate the in vivo efficacy of a COX-2 inhibitor in prostate cancer, NS398 was administered to mice inoculated with the PC-3 human prostate cancer cell line.A total of 28 male nude mice were inoculated subcutaneously with 1 million PC-3 cells. Tumors were palpable in all 28 animals 1 week after inoculation and mice were randomized to receive either vehicle (control) or NS398, 3 mg./kg. body weight, intraperitoneally three times weekly for 9 weeks. Tumors were measured at weekly intervals. After a 10-week experimental period, mice were euthanized and tumors were immuno- histochemically assayed for proliferation (PCNA), apoptosis (TUNEL) and microvessel density (MVD) (Factor-VIII-related antigen). Tumor VEGF content was assayed by Western blotting.NS398 induced a sustained inhibition of PC-3 tumor cell growth and a regression of existing tumors. Average tumor surface area from control mice was 285 mm.2 as compared with 22 mm.2 from treated mice (93% inhibition, p <0.001). Immunohistochemical analysis revealed that NS398 had no effect on proliferation (PCNA), but induced apoptosis (TUNEL) and decreased MVD (angiogenesis). VEGF expression was also significantly down regulated in the NS398-treated tumors.These results demonstrate that a selective COX-2 inhibitor suppresses PC-3 cell tumor growth in vivo. Tumor growth suppression is achieved by a combination of direct induction of tumor cell apoptosis and down regulation of tumor VEGF with decreased angiogenesis
Bundle Beaming From Multiple Subwavelength Slits Surrounded by Dielectric Surface Gratings (2010)

A method for rendering bundle beams by utilizing the destructive interference effects of beams from multiple subwavelength slits surrounded by dielectric surface gratings is proposed. With oblique incident light on the multiple slits, it is possible to control the phases of surface plasmon polaritons (SPPs) induced in the slits. When these phases have a certain relationship, beams from the SPPs excited on the corrugated surface render separated beams or bundle beams, as interfering destructively. Because of the destructive interference, separation between the beams is clear. In addition, the beam width of the bundle beams is narrow, in a degree of several wavelengths of the light.
Simplifying the Management of Large Photo Collections. (2003)

Abstract: With digital still cameras, users can easily collect thousands of photos. Our goal is to make organizing and browsing photos simple and quick, while retaining scalability to large collections. To that end, we created a photo management application concentrating on areas that improve the overall experience without neglecting the mundane components of such an application. Our application automatically divides photos into meaningful events such as birthdays or trips. Several user interaction mechanisms enhance the user experience when organizing photos. Our application combines a light table for showing thumbnails of the entire photo collection with a tree view that supports navigating, sorting, and filtering photos by categories such as dates, events, people, and locations. A calendar view visualizes photos over time and allows for the quick assignment of dates to scanned photos. We fine-tuned our application by using it with large personal photo collections provided by several users.
Netrin-1 controls sympathetic arterial innervation (2014)

Autonomic sympathetic nerves innervate peripheral resistance arteries, thereby regulating vascular tone and controlling blood supply to organs. Despite the fundamental importance of blood flow control, how sympathetic arterial innervation develops remains largely unknown. Here, we identified the axon guidance cue netrin-1 as an essential factor required for development of arterial innervation in mice. Netrin-1 was produced by arterial smooth muscle cells (SMCs) at the onset of innervation, and arterial innervation required the interaction of netrin-1 with its receptor, deleted in colorectal cancer (DCC), on sympathetic growth cones. Function-blocking approaches, including cell type-specific deletion of the genes encoding Ntn1 in SMCs and Dcc in sympathetic neurons, led to severe and selective reduction of sympathetic innervation and to defective vasoconstriction in resistance arteries. These findings indicate that netrin-1 and DCC are critical for the control of arterial innervation and blood flow regulation in peripheral organs.
Both Fidaxomicin and Vancomycin Inhibit Outgrowth of Clostridium difficile Spores (2012)

Fidaxomicin (FDX) is approved to treat Clostridium difficile-associated diarrhea and is superior to vancomycin in providing a sustained clinical response (cure without recurrence in the subsequent 25 days). The mechanism(s) behind the low recurrence rate of FDX-treated patients could be multifactorial. Here, we tested effects of FDX, its metabolite OP-1118, and vancomycin on spore germination and determined that none affected the initiation of spore germination but all inhibited outgrowth of vegetative cells from germinated spores.
ChemInform Abstract: A New Potential Acyliminium Ion for the Asymmetric Synthesis of Piperidine Derivatives. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Differential effects of adaptation on odor discrimination (2018)

Adaptation of neural responses is ubiquitous in sensory systems and can potentially facilitate many important computational functions. Here we examined this issue with a well-constrained computational model of the early olfactory circuits. In the insect olfactory system, the responses of olfactory receptor neurons (ORNs) on the antennae adapt over time. We found that strong adaptation of sensory input is important for rapidly detecting a fresher stimulus encountered in the presence of other background cues and for faithfully representing its identity. However, when the overlapping odorants were chemically similar, we found that adaptation could alter the representation of these odorants to emphasize only distinguishing features. This work demonstrates novel roles for peripheral neurons during olfactory processing in complex environments. NEW & NOTEWORTHY Olfactory systems face the problem of distinguishing salient information from a complex olfactory environment. The neural representations of specific odor sources should be consistent regardless of the background. How are olfactory representations robust to varying environmental interference? We show that in locusts the extraction of salient information begins in the periphery. Olfactory receptor neurons adapt in response to odorants. Adaptation can provide a computational mechanism allowing novel odorant components to be highlighted during complex stimuli.
Object serialization analysis and comparison in Java and .NET (2003)

This article compares binary and XML object serialization on Java and Microsoft .NET platforms from the performance and size perspective. It uses three different types of objects and different number of objects to make a comparison which reflects real-world circumstances. The article has the following contributions: (1) it compares binary and XML serialization between Java and .NET to compare the efficiency of both platforms; (2) it compares binary and XML serialization within the platforms to compare the differences between the two serialization types; (3) it studies the reasons for performance differences and provides possible performance optimizations.
Halide–Amine Co‐Passivated Indium Phosphide Colloidal Quantum Dots in Tetrahedral Shape (2016)

Wet chemical synthesis of covalent III-V colloidal quantum dots (CQDs) has been challenging because of uncontrolled surfaces and a poor understanding of surface-ligand interactions. We report a simple acid-free approach to synthesize highly crystalline indium phosphide CQDs in the unique tetrahedral shape by using tris(dimethylamino) phosphine and indium trichloride as the phosphorus and indium precursors, dissolved in oleylamine. Our chemical analyses indicate that both the oleylamine and chloride ligands participate in the stabilization of tetrahedral-shaped InP CQDs covered with cation-rich (111) facets. Based on density functional theory calculations, we propose that fractional dangling electrons of the In-rich (111) surface could be completely passivated by three halide and one primary amine ligands per the (2×2) surface unit, satisfying the 8-electron rule. This halide-amine co-passivation strategy will benefit the synthesis of stable III-V CQDs with controlled surfaces.
Germanium for advanced CMOS anno 2009: a SWOT analysis (2009)

Germanium has emerged as an exciting alternative material for high-performance scaled CMOS, however not without difficulties. After a review of the state-of-the-art, mainly focusing on two techniques to passivate the channel/dielectric interface, we analyze the strengths (carrier mobility, band gap), and weaknesses (n-type doping, lattice mismatch and BTBT leakage) of Ge for MOSFETs. We also identify some opportunities and the most important threats for the future of germanium.
Cumulant-Based Probabilistic Optimal Power Flow (P-OPF) With Gaussian and Gamma Distributions (2005)

This paper introduces the cumulant method for the probabilistic optimal power flow (P-OPF) problem. By noting that the inverse of the Hessian used in the logarithmic barrier interior point can be used as a linear mapping, cumulants can be computed for unknown system variables. Results using the proposed cumulant method are compared against results from Monte Carlo simulations (MCSs) based on a small test system. The Numerical Results section is broken into two sections: The first uses Gaussian distributions to model system loading levels, and cumulant method results are compared against four MCSs. Three of the MCSs use 1500 samples, while the fourth uses 20 000 samples. The second section models the loads with a Gamma distribution. Results from the proposed technique are compared against a 1000-point MCS. The cumulant method agrees very closely with the MCS results when the mean value for variables is considered. In addition, the proposed method has significantly reduced computational expense while maintaining accuracy.
Analysis methods for nonlinear models with compoun- symmetric covariance (1992)

Existing general methods for fitting nonlinear multivariate regression functions produce standard errors for parameter estimates which can be extremely optimistic when small samples are used. By incorporating the compound - symmetric covariance structure into the model where appropriate, substantial improvements in the estimation of the covariance matrix for the parameter estimates may be expected. An approximate weighted least squares method is described for fitting a nonlinear response function to repeated measures data with compound symmetric covariance for each independent sampling unit. The method is applicable to incomplete data. Under regularity conditions, the estimation procedure yields asymptotically normal, unbiased and consistent estimators. With complete Gaussian data, the procedure may be iterated to produce maximum likelihood estimates of response function parameters and variance components. Hypothesis testing following estimation procedures which either ignore or address the compound symmetry in simulated data are compared. Substantially smaller sample sizes are shown to yield the correct Type I error in the latter case
Vitamins E plus C and interacting conutrients required for optimal health (1998)

In CVD vitamin E acts as first risk discriminator, vitamin C as second one; optimal health requires synchronously optimized vitamins C + E, A, carotenoids and vegetable conutrients.
Polynomial Optics: A Construction Kit for Efficient Ray‐Tracing of Lens Systems (2012)

Abstract Simulation of light transport through lens systems plays an important role in graphics. While basic imaging properties can be conveniently derived from linear models (like ABCD matrices), these approximations fail to describe nonlinear effects and aberrations that arise in real optics. Such effects can be computed by proper ray tracing, for which, however, finding suitable sampling and filtering strategies is often not a trivial task. Inspired by aberration theory, which describes the deviation from the linear ray transfer in terms of wavefront distortions, we propose a ray‐space formulation for nonlinear effects. In particular, we approximate the analytical solution to the ray tracing problem by means of a Taylor expansion in the ray parameters. This representation enables a construction‐kit approach to complex optical systems in the spirit of matrix optics. It is also very simple to evaluate, which allows for efficient execution on CPU and GPU alike, including the computation of mixed derivatives of any order. We evaluate fidelity and performance of our polynomial model, and show applications in high‐quality offline rendering and at interactive frame rates.
An extended study: protective effects of nerve growth factor in neomycin-induced auditory neural degeneration. (1995)

Intracochlear survival of auditory neurons is thought to be a factor contributing to the success of cochlear implantations. Damage to the cochlear end-organ is frequently associated with loss of neurites in the osseous spiral lamina. The authors have previously reported a model for long-term intracochlear administration of pharmacologic agents using a technique and device analogous to a cochlear implant. These studies suggest that nerve growth factor (NGF) protects the auditory nerve from the immediate neurotoxic effects of neomycin. The intent of the present investigation is to determine whether NGF can protect auditory neural elements from neomycin-induced degeneration after several weeks have elapsed between the neomycin perfusion and the administration of NGF. Neomycin was infused over 24 hours through an indwelling, intracochlear cannula attached to a mini osmotic pump to unilaterally destroy the cochlear end-organ. The pump perfused the cochlea with artificial perilymph for 2 weeks. Then, the pump reservoirs were surgically replaced; the new reservoirs delivered either NGF or artificial perilymph for an additional 2 weeks. Spiral ganglion cell densities were measured along Rosenthal's canal in the basal, middle, and apical cochlear turns. This investigation revealed that NGF prevented auditory nerve degeneration over the 2-week period, when compared to controls, and that the protective effect was greatest in the neural elements closest to the source of NGF.
Preparation and In-vitro Evaluation of Rifampin-loaded Mesoporous Silica Nanoaggregates by an Experimental Design. (2015)

The goal of this research is preparation, optimization and in-vitro evaluation of rifampin-loaded silica nanoparticles in order to use in the pulmonary drug delivery. Nanoparticles are exhaled because of their small size. Preparation of nanoaggregates in a micron-size scale and re-dispersion of them after deposition in the lung is an approach to overcome this problem. We used this approach in our research. Rifampin was selected as a model lipophilic molecule since it was a well-documented and much used anti tuberculosis drug. A half factorial design was used to identify significant parameters of the spray drying process. The results showed that feed concentration, feed pH and the interaction between feed flow rate and gas atomizer flow rate had statistically significant effects on the particle size of nanoaggregates. The Box-Behnken design was employed to optimize the spray drying process. Finally, a quadratic equation which explains the relation between independent variables and aerodynamic diameter of nanoaggregates was obtained. Rifampin-loaded silica nanoaggregates underwent different in-vitro tests including: SEM, Aerosol performance and drug release. The in-vitro drug release was investigated with buffer phosphate (pH=7.4). Regarding the drug release study, a triphasic pattern of release was observed. The rifampin-loaded silica nanoaggregates were capable of releasing 90% drug content after 24 h in combination patterns of release. The prepared rifampin-loaded nanoaggregates seem to have a potential to be used in a pulmonary drug delivery.
3-D computer visualization and interactive prostate biopsy simulation leads to an improved systematic technique for the detection of prostate cancer: clinical correlation. (2000)

Our results suggest that biopsy protocols that use laterally placed biopsies based upon a five region anatomical model are superior to the routinely used sextant prostate biopsy pattern. Lateral biopsies in the apex and mid portion of the gland are the most important.
MOS switched-capacitor filters (1979)

In the past several years, much progress has been made in bringing the economies of integrated-circuit technology to bear on the realization of voiceband frequency selective filters. This paper will review one approach to this problem, the use of switched-capacitor techniques. The paper emphasizes the practical aspects of switched-capacitor filter design under the constraints imposed by MOS integrated-circuit technology. The basic operation of switched-capacitor filters is reviewed, followed by a discussion of the properties of the various circuit building blocks in MOS technology. Finally, a summary of several filter organizations which appear to be well suited to switched-capacitor implementation is presented.
Crosstalk Countermeasures for High-Density Inductive-Coupling Channel Array (2007)

Inductive coupling among stacked chips in a package enables 1 Gb/s/channel data communications. Array arrangement of the channel increases data bandwidth, while signal may be degraded by crosstalk. In this paper, crosstalk is measured and analyzed, and crosstalk countermeasures are discussed. Received signal waveforms through the inductive coupling are measured by embedded voltage detectors on a test chip. Interference-to-signal ratio (ISR) has good agreement between the measurements and calculations. It is found that crosstalk is reduced negligibly at a certain distance. If the channels are arranged at intervals of this distance, ISR is minimized. A technique based on time interleaving is also proposed to further reduce crosstalk. A 3times17 channel array is implemented with the crosstalk countermeasures. The channel pitch is taken down to 50 mum. Inter-chip communication with data rate of 1 Gb/s/channel and bit error rate (BER) lower than 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-9</sup> is demonstrated