gebhart/patrepeval huggingface dataset:
Design and performance of a low-noise charge-detection amplifier for VPCCD devices (1984)

This paper describes the design and performance of a low-noise amplifier used with virtual phase charge-coupled devices. Topology of the detection node, details of the operation, and computer simulations for critical device parameters are presented. Attention is focused on the noise performance and charge-detection sensitivity. A simple noise model is developed and used to derive an expression for the noise equivalent number of electrons <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">N_ee</tex> which is then used to optimize the amplifier design. Finally, predictions obtained from the model are compared with measurements, and conclusions are drawn for the maximum attainable performance. In addition to the thermally generated noise, usually measured in buried-channel MOS transistors, an excess noise is sometimes seen at moderate to large drain biases. This phenomenon is also observed in this amplifier. However, an explanation for the effect, confirmed by measurement, is presented and a method to avoid degradation of the amplifier performance is found.
Beyond UNIX - A True Distributed System for the 1990s (1990)

UNIX has been around now for almost 20 years.At the time UNIX began, most departments felt themselves well-endowed indeed if they owned a single PDP-11/45 with 256K memory and a 2.5M RK05 disk.Nowadays a laptop would be embarrassed to have only that.It is our hypothesis that UNIX is no longer the appropriate kind of operating system for the 1990s.In this paper, a new system, Amoeba, will be described, that we believe meets the requirements for distributed computing in the 1990s.
Identification of the Target of Monoclonal Antibody A6H as Dipeptidyl Peptidase IV/CD26 by LC MSMS (2001)

The monoclonal antibody (MAb) A6H, originally developed to fetal renal tissues, was found to be highly reactive to renal cell carcinoma and was subsequently demonstrated to co-stimulate a subpopulation of T cells. The A6H antigen had not been identified heretofore. Antigen from detergent extracts of renal cell carcinoma cells (7860) was immunoabsorbed with A6H-agarose, and the resin-bound proteins were separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). The antigen had a molecular weight of approximately 120 kDa as determined by Western blots. The 120-kDa protein band was excised and subjected to in-gel tryptic digestion, and the resulting peptides were separated and analyzed by liquid chromatography tandem mass spectrometry (LC MS\MS). The tandem mass spectra of the eluting peptides were used in combination with the SEQUEST computer program to search a human National Cancer Institute (NCI) protein database for the identity of the protein. The target antigen was shown to be dipeptidyl peptidase IV (DPP IV), which is also known as the cluster differentiation antigen CD26. Flow analysis of the expression of the A6H antigen and of CD26 on 7860 cells and on peripheral blood lymphocytes supported the identification of the A6H antigen as DPP IV. Recognition that the A6H antigen is DPP IV/CD26 afforded the opportunity to compare previous studies on A6H with those on other anti-CD26 antibodies in terms of expression in cancer cell lines and various tissues and as co-stimulators of T-cell activation.
Modeling multilayered PCB power-bus designs using an MPIE based circuit extraction technique (2002)

A circuit extraction tool (CEMPIE) has been developed based on the mixed-potential integral equation (MPIE) using a quasi-static approximation. A power-bus in a multi-layered PCB consisting of a pair of dedicated ground and power planes is studied using this tool. The distributed behavior of a power-bus is represented by a collection of passive circuit elements, which is valid up to several gigahertz. The decoupling performance of a power-bus due to its layer spacing and the dielectric constant is evaluated for simple test geometries. The impact of the relative distance between the noise source and the potential receiver is also studied. Novel structures such as a power island were studied in both thin and thick boards, and the decoupling performance due to the locations and values of the decoupling capacitors were also investigated.
Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis. (1996)

Breast cancer almost invariably metastasizes to bone in patients with advanced disease and causes local osteolysis. Much of the morbidity of advanced breast cancer is a consequence of this process. Despite the importance of the problem, little is known of the pathophysiology of local osteolysis in the skeleton or its prevention and treatment. Observations in patients with bone metastases suggest that breast cancer cells in bone express parathyroid hormone-related protein (PTHrP) more frequently than in soft tissue sites of metastasis or in the primary tumor. Thus, the role of PTHrP in the causation of breast cancer metastases in bone was examined using human breast cancer cell lines. Four of eight established human breast cancer cell lines expressed PTHrP and one of these cell lines, MDA-MB-231, was studied in detail using an in vivo model of osteolytic metastases. Mice inoculated with MDA-MB-231 cells developed osteolytic bone metastasis without hypercalcemia or increased plasma PTHrP concentrations. PTHrP concentrations in bone marrow plasma from femurs affected with osteolytic lesions were increased 2.5-fold over corresponding plasma PTHrP concentrations. In a separate experiment, mice were treated with either a monoclonal antibody directed against PTHrP(1-34), control IgG, or nothing before tumor inoculation with MDA-MB-231 and twice per week for 26 d. Total area of osteolytic lesions was significantly lower in mice treated with PTHrP antibodies compared with mice receiving control IgG or no treatment. Histomorphometric analysis of bone revealed decreased osteoclast number per millimeter of tumor/bone interface and increased bone area, as well as decreased tumor area, in tumor-bearing animals treated with PTHrP antibodies compared with respective controls. These results indicate that tumor-produced PTHrP can cause local bone destruction in breast cancer metastatic to bone, even in the absence of hypercalcemia or increased circulating plasma concentrations of PTHrP. Thus, PTHrP may have an important pathogenetic role in the establishment of osteolytic bone lesions in breast cancer. Neutralizing antibodies to PTHrP may reduce the development of destructive bone lesions as well as the growth of tumor cells in bone.
Inhibition of<i>Helicobacter pylori</i>and Associated Urease by Oregano and Cranberry Phytochemical Synergies (2005)

Ulcer-associated dyspepsia is caused by infection with Helicobacter pylori. H. pylori is linked to a majority of peptic ulcers. Antibiotic treatment does not always inhibit or kill H. pylori with potential for antibiotic resistance. The objective of this study was to determine the potential for using phenolic phytochemical extracts to inhibit H. pylori in a laboratory medium. Our approach involved the development of a specific phenolic profile with optimization of different ratios of extract mixtures from oregano and cranberry. Subsequently, antimicrobial activity and antimicrobial-linked urease inhibition ability were evaluated. The results indicated that the antimicrobial activity was greater in extract mixtures than in individual extracts of each species. The results also indicate that the synergistic contribution of oregano and cranberry phenolics may be more important for inhibition than any species-specific phenolic concentration. Further, based on plate assay, the likely mode of action may be through urease inhibition and disruption of energy production by inhibition of proline dehydrogenase at the plasma membrane.
Thin-film ferrite materials for microwave and millimeter wave integrated circuits (invited) (abstract) (1987)

Conventional microwave and millimeter wave systems use ferrites in a variety of components. In general, each application imposes specific requirements on the magnetic properties of the ferrite. In addition, some devices require the ferrite to be in single-crystal form. In order to produce ferrite components that are compatible with microwave and millimeter wave integrated circuits, additional constraints are imposed on the ferrite, especially if fully monolithic integration is required. In general, the ferrites must be prepared in thin film form on substrates that are chosen primarily to meet requirements other than compatibility with the ferrite film. Moreover, as is well known, the magnetic properties of ferrites are quite sensitive to the conditions that exist during their preparation. Thus, ferrites prepared by thin film deposition techniques may have properties different from bulk ferrites. This talk will review progress on methods for preparing polycrystalline ferrite films by techniques such as sputter deposition and laser-assisted deposition and methods for preparing single-crystal ferrite films in forms that may be compatible with epitaxial deposition of compound semiconductors.
Electrodeposition of Silver Alloy Powders on Rotating and Vibrating Cathodes (1983)

SummaryA detailed study of the manufacture of Ag-Sn and Ag-Sn-Cu powder deposits at rotating cylinder and vibrating cathodes is reported. The electrolyte used was a cyanide-stannate bath. The effects of cathode potential, mass transport (rotation rate of cylinder) and temperature were examined, as well as use of K+ in place of Na+ cations. It is shown that the silver deposition process is mass transport controlled, the tin activation controlled. There is no evidence to suggest that the various components of the bath interact with one another. The full range of Ag-Sn compositions can be formed as powders, and it appears that Cu in any proportion can be included in these powders. Powders having the composition of commercially available dental amalgam alloys (Ag-28% Sn, O-30% Cu) were prepared.
Granulocyte-macrophage colony-stimulating factor (GM-CSF) has opposing effects on the capacity of monocytes<i>versus</i>monocyte-derived dendritic cells to stimulate the antigen-specific proliferation of a human T cell clone (2000)

GM-CSF is widely used in combination with IL-4 to differentiate monocytes into potent T cell stimulatory cells, referred to as monocyte-derived dendritic cells (MoDC). These cytokines further increased the stimulatory function of MoDC when present during their incubation with antigen, as determined by the proliferative response of an allergen-specific T cell clone. Conversely, the incubation of freshly isolated monocytes with antigen in the presence of GM-CSF or GM-CSF and IL-4 strongly inhibited the specific stimulation of the T cells, compared with monocytes pulsed in the absence of cytokines. This suppression was partly due to the secretion of prostaglandin E2 (PGE2) and IL-10 by GM-CSF-treated monocytes, since the combined use of indomethacin and anti-IL-10 antibodies during GM-CSF incubation and antigen pulsing restored T cell growth to about 65% of control levels. As confirmed by culture supernatant transfer experiments, maximal inhibition of T cell stimulation was also dependent on the direct contact between the T cells and GM-CSF-treated monocytes during antigen presentation. Collectively, these results imply that GM-CSF can either inhibit or enhance the re-stimulation of primed T cells by antigen-presenting monocytes or MoDC, respectively.
Growth Hormone- and Prolactin-Induced Proliferation of Insulinoma Cells, INS-1, Depends on Activation of STAT5 (Signal Transducer and Activator of Transcription 5) (2001)

GH and PRL stimulate proliferation and insulin production of pancreatic β-cells. Whereas GH- and PRL-regulated transcription of the insulin gene in insulinoma cells has been shown to depend on STAT5 (signal transducer and activator of transcription 5), the signaling pathways involved in GH/PRL-induced β-cell replication are unknown. The roles of various signaling pathways in human GH (hGH)-induced DNA synthesis were studied by analysis of the effect of specific inhibitors in both the insulin-producing cell line, INS-1, and in primary β-cells. The mitogen-activated protein kinase kinase (MEK)-inhibitor, PD98059, as well as the mitogen-activated protein kinase p38 (MAPKp38) inhibitor, SB203580, partially inhibited hGH- induced proliferation in INS-1 cells but had no significant effect in primary β-cells. Staurosporine, a protein kinase C (PKC) and protein kinase A (PKA) inhibitor, blocked both basal and hGH-induced proliferation in INS-1 cells, but had no inhibitory effect in primaryβ -cells. Wortmannin, a phosphatidylinositol 3-kinase (PI3K) inhibitor, inhibited hGH-induced proliferation neither in INS-1 cells nor in primary β-cells, whereas the tyrosine kinase inhibitor, genistein, completely inhibited hGH- induced proliferation in both primary β-cells and INS-1 cells. To analyze the possible role of STAT5 in hGH-induced proliferation, a dominant negative STAT5 mutant, STAT5Δ749, was expressed in INS-1 cells under the control of a doxycycline- inducible promoter by stable transfection. Two clones were found to exhibit dose-dependent, doxycycline-inducible expression of STAT5Δ749 and suppression of hGH-stimulated transcriptional activation of a STAT5-regulated PRL receptor (PRLR) promoter-reporter construct. Furthermore, induction of STAT5Δ749 expression completely inhibited hGH-induced DNA synthesis. Analysis of endogenous gene expression revealed a doxycycline-dependent inhibition of hGH-stimulated PRLR and cyclin D2 mRNA levels. Our results suggest that GH/PRL-induced β-cell proliferation is dependent on the Janus Kinase2 (JAK2)/STAT5 signaling pathway but not the MAPK, PI3K, and PKC signaling pathways. Furthermore, the cell cycle regulator cyclin D2 may be a crucial target gene for STAT5 in this process.
Increase of insulin sensitivity in diabetic rats received die-huang-wan, a herbal mixture used in Chinese traditional medicine. (2002)

The present study found that oral administration of die-huang-wan increased insulin sensitivity and delayed the development of insulin resistance in rats.
A principled approach to operating system construction in Haskell (2005)

We describe a monadic interface to low-level hardware features that is a suitable basis for building operating systems in Haskell. The interface includes primitives for controlling memory management hardware, user-mode process execution, and low-level device I/O. The interface enforces memory safety in nearly all circumstances. Its behavior is specified in part by formal assertions written in a programming logic called P-Logic. The interface has been implemented on bare IA32 hardware using the Glasgow Haskell Compiler (GHC) runtime system. We show how a variety of simple O/S kernels can be constructed on top of the interface, including a simple separation kernel and a demonstration system in which the kernel, window system, and all device drivers are written in Haskell.
Security Enhancement for Lightweight JPEG 2000 Transparent Encryption (2006)

We present improvements in lightweight transparent JPEG 2000 encryption with lifting parameterized biorthogonal wavelet filters. Security is further enhanced by a combination with the wavelet packet transform. Different methods for the selection of a suitable wavelet packet basis are presented, which also make a certain amount of control in the trade-off between security and computational complexity possible. The combined approach of parameterized filters and wavelet packets is evaluated with regard to compression performance, complexity and security
290 fs switching time of Fe-doped quantum well saturable absorbers in a microcavity in 1.55μm range (2004)

Ultrafast all-optical switch has been demonstrated by inserting Fe-doped multiple quantum wells (MQWs) in asymmetric Fabry-Perot microcavities. Heavy Fe doping during the InGaAs∕InP MQW epitaxial growth is a well-controlled technique to reach subpicosecond optical time constants. An asymmetric Fabry-Perot microcavity using gold metal as a back mirror and air/InP interface as a front mirror is realized. Pump-probe experiments using a conventional scheme on such switching devices are investigated. The device reveals an ultrafast response time, as low as 290fs, for an iron concentration of 2×1019cm−3, a contrast ratio of 8dB, a threshold switching fluence of 3.5μJ∕cm−2, and a 37-nm 3-dB bandwidth in the 1.55-μm telecommunication spectral range.
Differential expression of mRNAs for alpha- and beta-tubulin during differentiation of the parasitic protozoan Leishmania mexicana. (1984)

The parasitic protozoan Leishmania mexicana amazonensis has two developmental stages: a motile flagellated promastigote stage and a sessile intracellular amastigote stage. In our previous work, cells of the promastigote stage were found to synthesize more tubulin protein than those of the amastigote stage. Here, tubulin mRNAs in these leishmanias were analyzed. Based on dot blot hybridization between total leishmanial RNA and tubulin-specific cDNA probes derived from chicken brain, amastigotes and promastigotes were found to have approximately equal amounts of alpha- and beta-tubulin mRNAs. RNA blotting of leishmanial RNA, using chicken tubulin cDNA probes, showed that amastigotes and promastigotes both gave a single mRNA species of 2100 nucleotides for alpha-tubulin in roughly similar quantities. However, such analysis for beta-tubulin revealed mainly a single mRNA species of 3600 nucleotides for amastigotes and three species of 2800, 3600, and 4400 nucleotides for promastigotes, the smallest mRNA being the most predominant. Thus, regulation of gene expression appears to be different only for beta-tubulin between the two developmental stages of this protozoan.
Kinetics and structural aspects of reconstitution of phosphatidylcholine vesicles by dilution of phosphatidylcholine-sodium cholate mixed micelles (1986)

Dilution of mixed micellar dispersions of egg phosphatidylcholine (PC) and sodium cholate beyond a critical value results in formation of cholate-containing PC vesicles. The structure of the resultant vesicles and some mechanistic aspects of this process have been investigated by the use of light scattering and nuclear magnetic resonance techniques. The main findings and conclusions are the following: Both the state of aggregation (micellar or vesicular) and the apparent equilibrium size distribution of micelles or vesicles obtained by dilution of the PC-cholate mixed micellar dispersions are a function of the cholate to PC molar ratio in the mixed aggregates (micelles or vesicles). When this effective ratio (Re) is higher than 0.4, the dispersion is micellar, and the size of the mixed micelles increases with decreasing Re; when Re less than 0.3, the dispersion is essentially vesicular, and the mean hydrodynamic radius of the vesicles is an increasing function of Re; in dispersions with 0.3 less than Re less than 0.4, mixed micelles and vesicles coexist. Addition of cholate to vesicular dispersions, to Re values below 0.3, results in vesicle size growth through a concentration-independent lipid-exchange mechanism. Addition of cholate to higher Re values results in micellization (solubilization) of the vesicles. On the other hand, dilution of vesicular dispersions does not affect the size of the vesicles. Apparent equilibration of a mixed micellar dispersion following dilution to Re values below 0.3 is slow (many hours). The overall process involves a series of three subsequent categories of steps: (i) a rapid (approximately 1-2 min) prevesiculation equilibration of micellar sizes.(ABSTRACT TRUNCATED AT 250 WORDS)
A Design of an Optimal Battery Pulse Charge System by Frequency-Varied Technique (2007)

In this paper, a variable frequency pulse charge system (VFPCS), that can detect and dynamically track the optimal charge frequency, is proposed to improve the battery-charge response. To assess the system performance, a prototype of the VFPCS for 600-mAh lithium-ion battery is designed and implemented. Compared with the standard constant-current and constant-voltage charge system, the charge speed of the proposed VFPCS is improved above 24%, while the proposed VFPCS is improved above 10% compared with the conventional fixed-frequency pulse charge system. The results indicate that the VFPCS can actually provide pulse with optimal frequency to charge the battery and the charge response is improved
Durable defense: robust and varied attachment of non-leaching poly“-onium” bactericidal coatings to reactive and inert surfaces (2014)

Developing antimicrobial coatings to eliminate biotic contamination is a critical need for all surfaces, including medical, industrial, and domestic materials. The wide variety of materials used in these fields, from natural polymers to metals, require coatings that not only are antimicrobial, but also contain different surface chemistries for covalent immobilization. Alkyl "-onium" salts are potent biocides that have defied bacterial resistance mechanisms when confined to an interface. In this feature article, we highlight the various methods used to covalently immobilize bactericidal polymers to different surfaces and further examine the mechanistic aspects of biocidal action with these surface bound poly"-onium" salts.
DRAM Scheduling Policy for GPGPU Architectures Based on a Potential Function (2011)

GPGPU architectures (applications) have several different characteristics compared to traditional CPU architectures (applications): highly multithreaded architectures and SIMD-execution behavior are the two important characteristics of GPGPU computing. In this paper, we propose a potential function that models the DRAM behavior in GPGPU architectures and a DRAM scheduling policy Î±-SJF policy to minimize the potential function. The scheduling policy essentially chooses between SJF and FR-FCFS at run-time based on the number of requests from each thread and whether the thread has a row buffer hit.
Oxidative deamination of hydrolyzed fumonisin B1 (AP1) by cultures ofExophiala spinifera (1999)

Fumonisins are mycotoxins of world-wide distribution in maize infected by the fungus Fusarium verticillioides. They are highly toxic to certain livestock and are potential carcinogens. Exophiala spinifera, a black yeast fungus found on moldy maize kernels, was identified previously as capable of growing on fumonisin B1 as a sole carbon source and thus is a potential source for fumonisin detoxifying enzymes. Pure cultures of E. spinifera transform fumonisin B(1) to the amino polyol AP(1) plus free tricarballylic acid through the activity of a soluble extracellular esterase, and further transformation is evidenced by accumulation in culture supernatant of a less polar compound(s) lacking a fluorescamine-reactive amino group. A free amine is thought to be critical for biological activity of FB(1) or AP(1). As a first step towards characterizing this amine-modifying activity, we investigated the biotransformation of AP(1) by E. spinifera liquid cultures that had been previously grown in liquid medium containing AP(1) as a sole carbon source. Accumulation of AP(1)-derived metabolites was monitored by thin-layer chromatography of culture supernatants, and product metabolites were purified and evaluated by mass spectrometry and nuclear magnetic resonance. Two products of treatment of purified AP(1) with cultures of E. spinifera are shown to be N-acetyl AP(1) and a new compound, 2-oxo-12,16-dimethyl-3,5,10, 14,15-icosanepentol hemiketal (or 2-OP(1) hemiketal).