gebhart/patrepeval huggingface dataset:
Multidrug resistance in ovarian cancer (1987)

The development of acquired resistance has limited the effectiveness of chemotherapy in the treatment of ovarian cancer. Experimental model systems were developed to study the mechanisms associated with primary resistance to chemotherapeutic agents and broad cross-resistance (multidrug resistance) which is characteristic of human ovarian cancer. Doxorubicin-resistant cell lines developed in vitro by exposure of a sensitive cell line to increasing concentrations of doxorubicin develop resistance on the basis of a decrease in drug accumulation and have increased expression of the mdr-1 gene. This gene encodes for a membrane glycoprotein and leads to a decreased drug accumulation in drug resistant cell lines. Cell lines established from patients refractory to doxorubicin-containing combinations, however, do not demonstrate a decrease in drug accumulation. Studies are in progress on the measurement of mdr-1 levels in tumors of patients undergoing treatment to determine whether agents, such as verapamil may be useful in the treatment of drug resistant gynecologic cancers. Human ovarian cancer cell lines from drug resistant patients also has been demonstrated to increase levels of glutathione. Lowering of glutathione levels with buthionine sulfoximine (BSO), which irreversibly inhibits the enzyme gamma-glutamyl cysteine synthetase, leads to a marked potentiation of the cytotoxicity of melphalan both in vitro and in vivo in a nude mouse model of human ovarian cancer. Based on those studies, BSO is undergoing toxicologic evaluation before initiation of clinical trials in drug resistant patients. Our studies demonstrate that drug resistance in human ovarian cancer is likely due to interaction of multiple factors. However, biochemical intervention in some of the key steps leading to drug resistance has been demonstrated experimentally feasible and indicates that pharmacologic reversal of drug resistance is a clinical possibility.
In-Situ Chemical Concentration Control for Wafer Wet Cleaning (1998)

This paper demonstrates the use of conductivity sensors to monitor and control the concentration of RCA cleaning and hydrofluoric acid (HF) etching solutions. Commercially available electrodeless conductivity sensors were used to monitor and control the concentration of these process solutions. A linear relationship between the conductivity of the solution and the chemical concentration was obtained within the range studied. A chemical injection scheme was developed to maintain the chemical concentration within specified limits. Different concentrations of RCA-based cleaning solutions and HF solutions were investigated. Results show that these techniques are suitable for monitoring and controlling the concentration of chemicals in the process tanks for better process control. These techniques provide low cost of ownership of the process by using dilute chemicals and longer bath life (i.e., a more environmentally sound process).
[Theoretical basis and application of evidence-based clinical pathway of Chinese medicine]. (2010)

Based on the principle of management, evidence-based medicine, operational research and health economics, this essay addressed the theoretical basis of clinical pathway and its application of evidence-based Chinese medicine to practice. It could be taken as references for different health care institutions and organizations for development of clinical pathway.
Novel Type of Career Generated System: Magnetic Investigations of TTF-Based Self-Doped Hydrogen-Bonding Conductor (2010)

Magnetic investigations, including static magnetic susceptibility and high-field electron spin resonance (ESR) measurements, were carried out for an organic conductor, (TTFCOO)[(NH 4 +1 ) 1- x (NH 3 ) x ]. Anisotropic ESR parameters were determined for powder samples using a high-frequency W-band (93.9817 GHz) ESR spectrometer. The observed principal values of the g -tensor and quantum chemical calculation results indicate that the observed spin is distributed on quasi-hole-like TTF skeletons, and that the TTFCOO mainframe partially becomes a neutral radical. The temperature dependence of the spin susceptibility is well fitted with a Curie–Weiss term and an activation-type term, with the activation-type term dominant at high temperatures. The high absolute value of the spin susceptibility and the extremely small activation energy, Δ, indicate that a quasi-degenerate (metallic) state is stabilized in (TTFCOO)[(NH 4 +1 ) 1- x (NH 3 ) x ], although the weakly temperature-dependent ESR linewidth indicates a localized characteristic. A novel type of carrier generation, self-doping, was discussed.
How Are Derivatives Used? Evidence from the Mutual Fund Industry (1996)

the problems and opportunities facing the financial services industry in its search for competitive excellence. The Center&apos;s research focuses on the issues related to managing risk at the firm level as well as ways to improve productivity and performance. The Center fosters the development of a community of faculty, visiting scholars and Ph.D. candidates whose research interests complement and support the mission of the Center. The Center works closely with industry executives and practitioners to ensure that its research is informed by the operating realities and competitive demands facing industry participants as they pursue competitive excellence. Copies of the working papers summarized here are available from the Center. If you would like to learn more about the Center or become a member of our research community, please let us know of your interest.
Report From Hong Kong (1995)

Hong Kong is a territory of only 400 square miles in size, but with a large population of six million people. We have excellent medical facilities in both the public and private sector and the general health indices of the population are good, with low infant mortality rates (5 per 1000) and long life expectancies (75 years for men and 80 for women).
Type A botulinum neurotoxin proteolytic activity: development of competitive inhibitors and implications for substrate specificity at the S<sub>1</sub>′ binding subsite (1998)

Type A botulinum neurotoxin (botox A) is a zinc metalloprotease that cleaves only one peptide bond in the synaptosomal protein, SNAP-25. Single-residue changes in a 17-residue substrate peptide were used to develop the first specific, competitive inhibitors of its proteolytic activity. Substrate analog peptides with P4, P3, P2' or P3' cysteine were readily hydrolyzed by the toxin, but those with P1 or P2 cysteine were not cleaved and were inhibitors. Peptides with either D- or L-cysteine as the N-terminus, followed by the last six residues of the substrate, were the most effective inhibitors, each with a Ki value of 2 microM. Elimination of the cysteine sulfhydryl group yielded much less effective inhibitors, suggesting that inhibition was primarily due to binding of the active-site zinc by the sulfhydryl group. Botox A displayed an unusual requirement for arginine as the P1' inhibitor residue, demonstrating that the S1' binding subsite of botox A is dissimilar to those of most other zinc metalloproteases. This characteristic is an important element in shaping the substrate specificity of botox A.
MoO3 nanoparticles dispersed uniformly in carbon matrix: a high capacity composite anode for Li-ion batteries (2011)

A MoO3–carbon nanocomposite was synthesized from a mixture of MoO3 and graphite by a controlled ball milling procedure. The as-prepared product consists of nanosized MoO3 particles (2–180 nm) homogeneously distributed in carbon matrix. The nanocomposite acts as a high capacity anode material for lithium-ion batteries and exhibits good cyclic behavior. Its initial capacity exceeds the theoretical capacity of 745 mA h g−1 in a mixture of MoO3 and graphite (1 : 1 by weight), and the stable capacity of 700 mA h g−1 (94% of the theoretical capacity) is still retained after 120 cycles. The electrode performance is linked with the unique nanoarchitecture of the composite and is compared with the performance of MoO3-based anode materials reported in the literature previously (nanoparticles, ball milled powders, and carbon-coated nanobelts). The high value of capacity and good cyclic stability of MoO3–carbon nanocomposite are attractive in respect to those of the reported MoO3 electrodes.
Calcium‐phosphate microprecipitates mimic microparticles when examined with flow cytometry (2012)

There are increased levels of circulating microparticles (MPs) in several disease states. Flow cytometry is a common method to examine MPs, but their small size necessitates the use of markers to distinguish specifically MPs from artifact. Annexin V, which binds phosphatidylserine, is a commonly used marker for MP detection. Annexin V requires millimolar calcium ion for optimum binding. Ca(++) can precipitate with phosphate in phosphate-buffered saline (PBS). Calcium-phosphate microprecipitates were formed by titrating Ca(++) into PBS and examined using flow cytometry. Calcium-phosphate microprecipitates were compared with MPs derived from aged donor blood units. Microprecipitates were ∼0.7-0.9 μm in diameter compared with standard beads of known size. The microprecipitates disappeared with the addition of Ca(++) chelator. When we added fluorescently labeled antibodies to microprecipitates, the median fluorescent signal increased with increasing Ca(++) concentration regardless of specificity of the antibody. When repeated with a biological sample, there was an apparent increase in the fluorescent signal that returned to baseline after Ca(++) chelation. The flow cytometry signal of calcium-phosphate microprecipitates overlaps with the MP signal. Since Ca(++) is essential for annexin V binding, it is essential to avoid artifacts from calcium-phosphate microprecipitates when using any buffer or biological fluid containing phosphate. This also highlights the potential utility of flow cytometry for the analysis of crystals in biological fluids.
Using picture books: Everyday experiences (2007)

Hilary White shows you how to use picture books as a starting point for exploring everyday experiences, such as ‘bedtime’, ‘washing hands’ and ‘mealtimes’.
Are distance-dependent statistical potentials considering three interacting bodies superior to two-body statistical potentials for protein structure prediction? (2014)

Distance-based statistical potentials have long been used to model condensed matter systems, e.g. as scoring functions in differentiating native-like protein structures from decoys. These scoring functions are based on the assumption that the total free energy of the protein can be calculated as the sum of pairwise free energy contributions derived from a statistical analysis of pair-distribution functions. However, this fundamental assumption has been challenged theoretically. In fact the free energy of a system with N particles is only exactly related to the N-body distribution function. Based on this argument coarse-grained multi-body statistical potentials have been developed to capture higher-order interactions. Having a coarse representation of the protein and using geometric contacts instead of pairwise interaction distances renders these models insufficient in modeling details of multi-body effects. In this study, we investigated if extending distance-dependent pairwise atomistic statistical potentials to corresponding interaction functions that are conditional on a third interacting body, defined as quasi-three-body statistical potentials, could model details of three-body interactions. We also tested if this approach could improve the predictive capabilities of statistical scoring functions for protein structure prediction. We analyzed the statistical dependency between two simultaneous pairwise interactions and showed that there is surprisingly little if any dependency of a third interacting site on pairwise atomistic statistical potentials. Also the protein structure prediction performance of these quasi-three-body potentials is comparable with their corresponding two-body counterparts. The scoring functions developed in this study showed better or comparable performances compared to some widely used scoring functions for protein structure prediction.
Double‐blind study of the effect of cisapride on constipation and abdominal discomfort as components of the irritable bowel syndrome (1997)

These results indicate that cisapride is not superior to placebo in the treatment of constipation and abdominal discomfort as components of irritable bowel syndrome. It may, however, be of use in improving the difficulty of stool passage.
A 1.5 Gb/s link interface chipset for computer data transmission (1991)

The authors designed a set of four ICs to provide encoding, multiplexing, clock extraction/demultiplexing, and decoding for gigabit-rate serial data transmission. These chips form a high bandwidth data link for point-to-point communication. A new line code is implemented that provides DC balance, efficient encoding, framing, and simple clock extraction. Embedded in the code is a fixed transition used by the phase/frequency locked loop (PLL) for simple clock extraction and frame synchronization. Unlike other links, this PLL requires no trimming for data retiming, either in production or later. An on-chip voltage-controlled oscillator (VCO) with a tuning range of 1.1-1.6 GHz is available for use with the PLL. With this chip set the authors demonstrated a transmission rate of 16 bits in parallel at 75 MHz or, with encoding overhead, a serial rate of 1.5 Gb/s.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
CD1d-antibody fusion proteins target iNKT cells to the tumor and trigger long-term therapeutic responses (2012)

Despite the well-established antitumor activity of CD1d-restricted invariant natural killer T lymphocytes (iNKT), their use for cancer therapy has remained challenging. This appears to be due to their strong but short-lived activation followed by long-term anergy after a single administration of the CD1d agonist ligand alpha-galactosylceramide (αGC). As a promising alternative, we obtained sustained mouse iNKT cell responses associated with prolonged antitumor effects through repeated administrations of tumor-targeted recombinant sCD1d-antitumor scFv fusion proteins loaded with αGC. Here, we demonstrate that CD1d fusion proteins bound to tumor cells via the antibody fragment specific for a tumor-associated antigen, efficiently activate human iNKT cell lines leading to potent tumor cell lysis. The importance of CD1d tumor targeting was confirmed in tumor-bearing mice in which only the specific tumor-targeted CD1d fusion protein resulted in tumor inhibition of well-established aggressive tumor grafts. The therapeutic efficacy correlated with the repeated activation of iNKT and natural killer cells marked by their release of TH1 cytokines, despite the up-regulation of the co-inhibitory receptor PD-1. Our results demonstrate the superiority of providing the superagonist αGC loaded on recombinant CD1d proteins and support the use of αGC/sCD1d-antitumor fusion proteins to secure a sustained human and mouse iNKT cell activation, while targeting their cytotoxic activity and cytokine release to the tumor site.
Systemic Lupus Erythematosus in Dogs and Cats (1983)

Systemic lupus erythematosus (SLE) is an autoimmune disease affecting multiple systems and has been reported in humans, dogs, and cats. Although known since the 19th century in humans, SLE was not recognized in the dog until 1965.1 Since the first case:report, a num-ber of cases have been documented in the dog. On the other hand, the first case of SLE to be suspected in the cat was in 1971,2 and only five further cases have appeared in the litera-ture. 3,4,S,6 The · incidence of SLE in dogs and cats has not been estimated; however, the incidence in humans has been speculated to be approxi-mately 5 cases per 100,000 population. 7 In hu-
Service on Demand: Drone Base Stations Cruising in the Cellular Network (2017)

In this paper, the deployment of drone base stations to provide higher performance in the cellular networks is analyzed. In particular, we investigate a new mobility model for drone base stations where they can move freely in the network, ignoring the cell boundaries. Free movement model for drones bring out new challenges such as user association and physical collision among drones. We consider two user association schemes and evaluate their performance through simulation. We show that by deploying a smart user association scheme in the free movement model, the obtained results are greatly better than those restricting each drone base station to fly over a certain small cell area, and serving local users. Additionally, the impact of drones' movement on the load balance, signal strength and interference are studied. Moreover, we show that our proposed algorithm can maintain a comfortable distance among the drones to avoid physical collision.
A consideration of the use of metamaterials for sensing applications: field fluctuations and ultimate performance (2007)

We analysed some peculiarities of electromagnetic metamaterials convenient for plasmon-based chemical sensing with enhanced sensitivity. Owing to the vastly extended range of possible values of refractive index, a higher degree of design freedom is enabled in comparison to conventional surface plasmon sensors. After considering some possible approaches to use metamaterials as either surface or bulk adsorbents, we analysed the ultimate performance of such sensing devices which are limited by refractive index fluctuations caused by adsorption and desorption processes. We utilized an approach based on a parallel between the adsorption-desorption mechanism and the carrier generation-recombination in semiconductors. As a special case, we considered structures for the detection of a single gas and used our approach to calculate the spectral density of refractive index fluctuations. We believe that our analysis may be of importance in different practical fields, including e.g.environmental sensing, homeland security and biosensing.
Facile Synthesis of Highly Fluorescent <i>Boranil</i> Complexes (2011)

Complexation of a large variety of Anils (aniline-imines) with boron(III) precursors provides stable Boranils, some of which have been structurally characterized. Analysis of their optical properties reveals that the fluorescence stems from an intraligand charge transfer (ILCT) state with the best quantum yields reaching 90%. Chemistry on the Boranils allows grafting of photoactive modules acting as energy antennae for borondipyrromethene (Bodipy) and subphtalocyanine (SubPc) fluorophores.
Aircraft Structural Morphing using Tendon-Actuated Compliant Cellular Trusses (2005)

Recently, smoothly-deforming aircraft structures have been investigated for their ability to adapt to varying flight conditions. Researchers aim to achieve large changes in the shape of the wings: area changes of up to 50% and aspect-ratio changes of up to 200% are being pursued. The research described in this paper aims to develop a structural concept capable of achieving continuous stable deformations over a large range of aircraft shapes. The basic concept underlying the approach is a compliant cellular truss, with tendons used as active elements. The truss members of the unit cell are connected through compliant joints such that only modest bending moments may be transmitted from one member to another. Actuation is achieved by pulling on one set of cables while releasing another set. The tendonactuated compliant truss can be made to behave locally, and temporarily, as a nearmechanism, by releasing appropriate cables. As a result, in the absence of aerodynamic forces, the structure can be morphed using relatively low forces. The cables are reeled in or released in a controlled manner while the structure is loaded, hence, the stability of the structure can be maintained in any intermediate position. Highly-distributed actuation also enables the simultaneous achievement of global shape changes as the accumulation of local ones, while the use of compliant joints rather than true rotating joints eliminates binding as a significant concern. A six-noded octahedral cell with diagonal tendon actuation is developed for a bending type deformation in the wing. Initial cell geometry is determined by “strain matching” to the local morphing deformation required by the application. A finite element analysis is performed on a wing made of these unit cells and sized for a representative UAV weighing 3000 lbs. The areas of the individual truss members are sized so that they don’t fail or buckle under the air loads, while deflection at the wing tip is reduced. The octahedral unit cell is capable of achieving smooth deformations of the truss structure. The cell size is dictated by the available space and the morphing strain. The cell sizes are reasonable for strains on the order of 10% to 15% and get smaller for larger strains. Additional cell shapes are being investigated for larger area changes through a process of topology optimization using genetic algorithms. Numerous other technical challenges remain, including the details of actuation and a robust skin.
An <i>in vitro</i> assessment of the role of Tooth Mousse in preventing wine erosion (2008)

TM may have significant role in the management of wine erosion, which is under-recognized as an occupational hazard by the Australian wine industry. Future studies are needed to compare the relative benefits of TM and other remineralizing agents, when used individually or in combination, in preventing dental erosion.
Neurologic Abnormalities in a Patient With Human Ehrlichiosis (1990)

Human ehrlichiosis is a tick-borne rickettsial disease characterized by fever, headache, myalgias, anorexia, and occasionally rash. In our patient, changes in mental status, upper motor neuron signs, cerebrospinal fluid pleocytosis, and increased serum protein levels were found in association with serologically confirmed ehrlichiosis and were most likely due to vasculitis involving the central nervous system. Intraleukocytic inclusions, although observed in our case, have been infrequently found in other reported cases of ehrlichiosis.
Improving sensitivity in micro‐free flow electrophoresis using signal averaging (2009)

Microfluidic free-flow electrophoresis (microFFE) is a separation technique that separates continuous streams of analytes as they travel through an electric field in a planar flow channel. The continuous nature of the microFFE separation suggests that approaches more commonly applied in spectroscopy and imaging may be effective in improving sensitivity. The current paper describes the S/N improvements that can be achieved by simply averaging multiple images of a microFFE separation; 20-24-fold improvements in S/N were observed by averaging the signal from 500 images recorded for over 2 min. Up to an 80-fold improvement in S/N was observed by averaging 6500 images. Detection limits as low as 14 pM were achieved for fluorescein, which is impressive considering the non-ideal optical set-up used in these experiments. The limitation to this signal averaging approach was the stability of the microFFE separation. At separation times longer than 20 min bubbles began to form at the electrodes, which disrupted the flow profile through the device, giving rise to erratic peak positions.