gebhart/patrepeval huggingface dataset:
Depression, subjective cognitive decline, and the risk of neurocognitive disorders (2019)

The findings may change the clinical approach in managing SCD in depression, suggesting the need for greater emphasis on detecting prodromal NCD. They may also have implications to our understanding of NCD, suggesting the need for further research to delineate the commonalities and distinctions in the neurobiological pathways of depression and SCD.
Small-Animal PET Imaging of Human Epidermal Growth Factor Receptor Positive Tumor with a <sup>64</sup>Cu Labeled Affibody Protein (2010)

Epidermal growth factor receptor (EGFR) has become an attractive target for cancer molecular imaging and therapy. Affibody proteins against EGFR have been reported, and thus, we were interested in evaluating their potential for positron emission tomography (PET) imaging of EGFR positive cancer. An Affibody analogue (Ac-Cys-Z(EGFR:1907)) binding to EGFR was made through conventional solid phase peptide synthesis. The purified protein was site-specifically coupled with the 1,4,7,10-tetraazacyclododecane-1,4,7-tris-aceticacid-10-maleimidethylacetamide (maleimido-mono-amide-DOTA) to produce the bioconjugate, DOTA-Z(EGFR:1907). (64)Cu labeled probe (64)Cu-DOTA-Z(EGFR:1907) displayed a moderate specific activity (5-8 MBq/nmol, 22-35 microCi/microg). Cell uptake assays by pre-incubating without or with 300 times excess unlabeled Ac-Cys-Z(EGFR:1907) showed high EGFR-specific uptake (20% applied activity at 0.5 h) in A431 epidermoid carcinoma cancer cells. The affinity (K(D)) of (64)Cu-DOTA-Z(EGFR:1907) as tested by cell saturation analysis was 20 nM. The serum stability test showed excellent stability of the probe with >95% intact after 4 h of incubation in mouse serum. In vivo small-animal PET imaging showed fast tumor targeting, high tumor accumulation (approximately 10% ID/g at 1 h p.i.), and good tumor-to-normal tissue contrast of (64)Cu-DOTA-Z(EGFR:1907) spiked with a wide dose range of Ac-Cys-Z(EGFR:1907). Bio-distribution studies further demonstrated that the probe had high tumor, blood, liver, and kidney uptakes, while blood radioactivity concentration dropped dramatically at increased spiking doses. Co-injection of the probe with 500 microg of Ac-Cys-Z(EGFR:1907) for blocking significantly reduced the tumor uptake. Thus, (64)Cu-DOTA-Z(EGFR:1907) showed potential as a high tumor contrast EGFR PET imaging reagent. The probe spiked with 50 microg of Ac-Cys-Z(EGFR:1907) improved tumor imaging contrast which may have important clinical applications.
A CMOS-based tactile sensor for continuous blood pressure monitoring (2004)

A monolithic integrated tactile sensor array is presented, which is used to perform non-invasive blood pressure monitoring of a patient. The advantage of this device, compared to a hand cuff based approach, is the capability of recording continuous blood pressure data. The capacitive, membrane-based sensor device is fabricated in an industrial CMOS-technology combined with post-CMOS micromachining. The capacitance change is detected by a /spl Sigma/-/spl Delta/ modulator. The modulator is operated at a sampling rate of 128 kS/s and achieves a resolution of 12 bit with an external decimation filter and an OSR of 128.
False-Negative Hybrid Capture II Results Related to Altered Adhesion Molecule Distribution in Women with Atypical Squamous Cells Pap Smear Results and Tissue-Based Human Papillomavirus-Positive High-Grade Cervical Intraepithelial Neoplasia (2004)

Previous research linked false-negative cytologic results in women with high-grade CIN to altered adhesion molecule distribution and impaired exfoliation, and a similar phenomenon may be responsible for false-negative HCII results in women with atypical squamous cells cytologic results and high-grade CIN.
Nanoparticle induced self-assembly (2008)

Self-assembly has for the large part focused on the assembly of molecules without guidance or management from an outside source. However, self-assembly is in principle by no means limited to molecules or the nanoscale. A particularly interesting method to the self-assembly of micro- to millimetre sized components is the use of the 'magnetic hole' effect. In this method, nonmagnetic particles can be manipulated by external magnetic fields by immersing them in a dispersion of colloidal, magnetic nanoparticles, denoted ferrofluids. Nonmagnetic particles in magnetized ferrofluids are in many ways ideal model systems to test various forms of particle self-assembly and dynamics. When microspheres are confined to a monolayer between two parallel plates and subjected to static or oscillating magnetic fields they show a variety of dynamical behaviours and assemblages, depending on the frequency and direction of the external fields. A single pair of magnetic holes oscillating in a ferrofluid layer may be used to measure the viscosity of tiny volumes of the fluid. We have also observed ordering of dilute dispersions of macromolecules and nanoparticles in magnetized ferrofluids. The self-assembly at this length scale results from structural correlations between these nanostructures and ferrofluid particles rather than from the macroscopic magnetostatic effect for the magnetic holes.
Analysis of senile changes in the palpebral fissure. (1975)

This work was carried out to determine the changes in conformity and physiological movements of the eyelids with advancing age. Some conceptions fostered in the literature are false and should be discarded. Others have been corroborated. We concluded that the whole lateral canthus becomes lax and drifts medially with age. Therefore, surgical correction should aim at restoring the fixation of the lateral canthus to the youthful position.
Music intervention in the intensive care unit: a complementary therapy to improve patient outcomes (2004)

Inherent in illness and hospitalisation are many stressors, which manifest themselves in patient responses including physiological signs of sympathetic nervous system activation and psychological distress that necessitates treatment with pharmacological agents. A wide range of medical conditions combined with exposure to the unique environmental circumstances of the intensive care unit elicit problematic patient behaviour patterns requiring the application of physical and/or use of chemical restraints. Patient responses to stress experienced as a result of illness and hospitalisation may have deleterious effects, potentially exacerbating pathological conditions and increasing the complexity and decreasing the cost effectiveness of nursing care.

Evidence of the beneficial effects of music on the physiological, psychological, and social reaction of the patient was derived from an extensive literature review. Historical sources provided observations relating to the calming and healing effects of music from such diverse sources as Pythagoras, biblical commentary, and treatises from students of the 19th century Philadelphia physician Benjamin Rush. …
Inactivation of CD11b in a mouse transgenic model protects against sepsis-induced lung PMN infiltration and vascular injury (2005)

To inactivate chronically the beta2-integrin CD11b (Mac-1), we made a transgenic model in mice in which we expressed the CD11b antagonist polypeptide neutrophil inhibitory factor (NIF). Using these mice, we determined the in vivo effects of CD11b inactivation on polymorphonuclear leukocyte (PMN) function and acute lung injury (ALI) induced by Escherichia coli septicemia. In wild-type PMNs, CD11b expression was induced within 1 h after E. coli challenge, whereas this response was significantly reduced in NIF(+/+) PMNs. Coimmunoprecipitation studies showed that NIF associated with CD11b in NIF(+/+) PMNs. To validate the effectiveness of CD11b blockade, we compared PMN function in NIF(+/+) and Mac-1-deficient (Mac-1(-/-)) mice. Adhesion of both Mac-1(-/-) and NIF(+/+) PMNs to endothelial cells in response to LPS was reduced in both types of PMNs and fully blocked only by the addition of anti-CD11a monoclonal antibody. This finding is indicative of intact CD11a function in the NIF(+/+) PMNs but the blockade of CD11b function. CD11b inactivation in NIF(+/+) mice interfered with lung PMN infiltration induced by E. coli and prevented the increase in lung microvessel permeability and edema formation, with most of the protection seen in the 1-h period after the E. coli. Thus our results demonstrate that CD11b plays a crucial role in mediating lung PMN sequestration and vascular injury in the early phase of gram-negative septicemia. The NIF(+/+) mouse model, in which CD11b is inactivated by binding to NIF, is a potentially useful model for in vivo assessment of the role of PMN CD11b in the mechanism of vascular inflammation.
Truth revelation in approximately efficient combinatorial auctions (1999)

Some important classical mechanisms considered in Microeconomics and Game Theory require the solution of a difficult optimization problem. This is true of mechanisms for combinatorial auctions, which have in recent years assumed practical importance, and in particular of the gold standard for combinatorial auctions, the Generalized Vickrey Auction (GVA). Traditional analysis of these mechanisms -in particular, their truth revelation properties -assumes that the optimization problems are solved precisely. In reality, these optimization problems can usually be solved only in an approximate fashion. We investigate the impact on such mechanisms of replacing exact solutions by approximate ones. Specifically, we look at a particular greedy optimization method, which has empirically been shown to perform well. We show that the GVA payment scheme does not provide for a truth revealing mechanism. We introduce another scheme that does guarantee truthfulness for a restricted class of players. We demonstrate the latter property by identifying sufficient conditions for a combinatorial auction to be truth-revealing, conditions which have applicability beyond the specific auction studied here.
A study of time redundant fault tolerance techniques for superscalar processors (2002)

As more and more transistors are incorporated into processor chips, the circuits are becoming more and more error-prone, necessitating the introduction of fault tolerance techniques. This paper investigates techniques to incorporate fault tolerance in superscalar processors by exploiting the functional unit redundancy available in these processors. The schemes investigated in this paper do not require any modifications to the instruction set architecture of the machine, and no additional instructions are added by the compiler. The paper also presents the results of a simulation study that we conducted to analyze the performance impact of the investigated fault tolerance schemes.
Combined cytotoxic chemotherapy and immunotherapy of cancer: modern times (2020)

Monoclonal antibodies targeting programmed cell death 1/programmed cell death ligand 1 (PD-1/PD-L1) immune checkpoints have improved the treatments of cancers. However, not all patients equally benefit from immunotherapy. The use of cytotoxic drugs is practically inevitable to treat advanced cancers and metastases. The repertoire of cytotoxics includes 80 products that principally target nucleic acids or the microtubule network in rapidly proliferating tumor cells. Paradoxically, many of these compounds tend to become essential to promote the activity of immunotherapy and to offer a sustained therapeutic effect. We have analyzed each cytotoxic drug with respect to effect on expression and function of PD-(L)1. The major cytotoxic drugs-carboplatin, cisplatin, cytarabine, dacarbazine, docetaxel, doxorubicin, ecteinascidin, etoposide, fluorouracil, gemcitabine, irinotecan, oxaliplatin, paclitaxel and pemetrexed-all have the capacity to upregulate PD-L1 expression on cancer cells (via the generation of danger signals) and to promote antitumor immunogenicity, via activation of cytotoxic T lymphocytes, maturation of antigen-presenting cells, depletion of immunosuppressive regulatory T cells and/or expansion of myeloid-derived suppressor cells. The use of 'immunocompatible' cytotoxic drugs combined with anti-PD-(L)1 antibodies is a modern approach, not only for increasing the direct killing of cancer cells, but also as a strategy to minimize the activation of immunosuppressive and cancer cell prosurvival program responses.
Respiration Measurement System using Textile Capacitive Pressure Sensor (2010)

In this paper, we proposed a wearable respiration measurement system with textile capacitive pressure sensor. Belt typed textile capacitive pressure sensor approach of respiration measurement, from which respiration signatures and rates can be derived in real-time for long-term monitoring, are presented. Belt typed textile capacitive pressure sensor has been developed for this measurement system. the distance change of two plates by the pressure of motion has been used for the respiration measurement in chest area. Respiration rates measured with the textile capacitive pressure sensor was compared with standard techniques on 8 human subjects. Accurate measurement of respiration rate with developed sensor system is shown. The data from the method comparison study is used to confirm theoretical estimates of change in capacitance by the distance change. The current version of respiratory rate detection system using textile capacitive pressure sensor can successfully measure respiration rate. It showed upper limit agreement of RPM, and lower limit of agreement of RPM in Bland-Altman plot. From all subject, high correlation were shown(p
Magnetic Tunneling Effect (1993)

Spin-polarized electron tunneling between ferromagnetic metal layers is a phenomenon of considerable interest. The tunneling conductance changes with the angle between the magnetization vectors of these ferromagnetic layers (the magnetic valve effect). Although only a small number of experiments on the magnetic valve effect have been reported, it poses interesting possibilities from the standpoint of both basic material science and of applications. This paper reviews briefly the literature on the magnetic valve effect, including some theories and experiments on ferromagnetic tunneling junctions, ferromagnetic multilayer films and ferromagnetic double-layer films.
Investigation on Process Parameters Involved in Polylactide-Co-Glycolide Microspheres Preparation (1995)

Indomethacin loaded polylactide-co-glycolide (PLGA) microspheres were prepared by emulsification solvent evaporation. The preparation involves several process parameters that can affect the morphological characteristics, the “in vitro” and “in vivo” dissolution behaviour of microspheres.The evaluation of three process parameters, emulsification stirring rate, emulsifier concentration and dispersed phase to continuous phase ratio was carried out in order to correlate them to some microsphere properties.Results show that the variables evaluated affect mainly microspheres drug content and, at less extent, particle size.
Characteristics of Al<sub>2</sub>O<sub>3</sub>-SiC Nanocomposite Prepared by Sol-Gel Processing (1994)

Al2O3-SiC nanocomposite powders containing small crystalline SiC powders have been prepared by sol-gel processing. Less than 50nm ultrasonic dispersion and sedimentation techniques were used in the presence of an organic solvent to remove the agglomerates of SiC. Homogeneous SiC powders with narrow size distributions were mixed with an Al2O3 sol. The characteristics of the nanocomposite powder as well as microstructure of the sintered Al2O3-SiC nanocomposite were investigated by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Sol-gel processing was shown to produce Al2O3-SiC nanocomposites with homogeneous distribution of SiC in the Al2O3 matrix.
Blind phase recovery in QAM communication systems using higher order statistics (1996)

We present a method for phase recovery in QAM communication systems based on higher order statistics. Under the assumption that the QAM signals have independent, identically distributed (i.i.d.) in-phase and quadrature components, we derive the relation between the phase error and the fourth-order cumulant of the output. Numerical performance of the approach is demonstrated by computer simulation.
The Effect of Diluent on Combustion Synthesis of Si<sub>3</sub>N<sub>4</sub>-SiC-TiN Ceramics with Small Diameter (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
A new self-aligned contact technology (1980)

A new self-aligned contact technology suitable for high density MOS VLSI is proposed. This technology includes phosphorus doped polysilicon oxidation under high pressure and low temperature, and the formation of polysilicon cover or interconnection on self-aligned contact region. Large differential oxidation ratio (5:1) of doped polysilicon to lightly doped silicon substrate can be easily obtained. The SiO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> film on the polysilicon gate acts as an excellent interlevel insulator. It is verified that this technology is readily applicable to conventional Si-gate MOS processes. Further, packing density increase of MOS VLSI due to this technology is estimated.
Deposition of ultrathin AlN films for high frequency electroacoustic devices (2011)

The authors investigate the microstructure, crystal orientation, and residual stress of reactively sputtered aluminum nitride (AlN) films having thicknesses as low as 200 down to 25 nm. A two-step deposition process by the dual cathode ac (40 kHz) powered S-gun magnetron enabling better conditions for AlN nucleation on the surface of the molybdenum (Mo) bottom electrode was developed to enhance crystallinity of ultrathin AlN films. Using the two-step process, the residual in-plane stress as well as the stress gradient through the film thickness can be effectively controlled. X-ray rocking curve measurements have shown that ultrathin films grown on Mo using this technology are highly c-axis oriented with full widths at half maximum of 1.8° and 3.1° for 200- and 25-nm-thick films, respectively, which are equal to or even better than the results previously reported for relatively thick AlN films. High-resolution transmission electron microscopy and fast Fourier transform analyses have confirmed strong grain orientation in 25–100-nm-thick films. A fine columnar texture and a continuous lattice microstructure within a single grain from the interface with the Mo substrate through to the AlN surface have been elicited even in the 25-nm-thick film.
Stereochemistry of the Core Structure of the Mycolactones (2001)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTStereochemistry of the Core Structure of the MycolactonesAndrew B. Benowitz, Steve Fidanze, P. L. C. Small, and Yoshito KishiView Author Information Department of Chemistry and Chemical Biology Harvard University, Cambridge, Massachusetts 02138 Department of Microbiology University of Tennessee, Knoxville, Tennessee 37996 Cite this: J. Am. Chem. Soc. 2001, 123, 21, 5128–5129Publication Date (Web):May 5, 2001Publication History Received28 February 2001Published online5 May 2001Published inissue 1 May 2001https://pubs.acs.org/doi/10.1021/ja0105414https://doi.org/10.1021/ja0105414rapid-communicationACS PublicationsCopyright © 2001 American Chemical SocietyRequest reuse permissionsArticle Views1572Altmetric-Citations78LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Biological databases,Chemical structure,Cluster chemistry,Molecular structure,Stereochemistry Get e-Alerts
A High‐Efficiency Single‐Phase Utility Interactive Inverter with an Active Power Decoupling Function and its Control Method (2016)

SUMMARY The present paper introduces a single‐phase utility interactive inverter with a power decoupling function. In a conventional single‐phase inverter, power pulsation at twice the grid frequency appears in the input power. Hence, electrolytic capacitors having large capacitances have been connected to the DC input terminal to stabilize the input DC‐bus voltage. Because the lifetime of the electrolytic capacitor is relatively shorter than that of another component, the lifetime of the inverter is affected by the capacitor. In order to prevent such a problem, a novel single‐phase inverter circuit with an active power decoupling function is introduced. The pulsating power on the input DC‐bus line and the pulsated energy on the input DC capacitor is transferred to the energy in a small film capacitor. Hence, the extension of the inverter lifetime can be expected by substituting a small film capacitor for the large electrolytic capacitors. In addition, the loss in the power decoupling circuit is very small; hence, the reduction in the overall conversion efficiency of the inverter can be minimized. The effectiveness of the proposed method is verified using a 300 W experimental setup.
Effect of Virus Infections on the Function of the Immune System (1970)

CONTENTS INTRODUCTION. • • • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 525 HUMORAL IMMUNITy 526 CELLULAR IMMUNITy 532 RETICULOENDOTHELIAL SYSTEM AND PHAGOCYTOSIS • . . . . . . . . . . . . . . . . . . . . . . , 533 IMPLICATIONS. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 534 SUMMARY. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • 535