gebhart/patrepeval huggingface dataset:
Effect of Human Granulocytic Elastase on Isolated Human Antithrombin III (1981)

The interaction of elastase isolated from human granulocytes with purified human antithrombin III was investigated. Antithrombin III did not display any inhibitory effect on granulocytic elastase. Dependent on enzyme concentration, however, granulocytic elastase induced progressive inactivation of antithrombin III leading to an almost complete loss of the thrombin inhibitory activity at a molar ratio of elastase: antithrombin III = 0.4:1 within 5 min at 25 degrees C. Antithrombin III is not drastically degraded by elastase as revealed by polyacrylamide gel electrophoretic and rocket immunoelectrophoretic investigations. However, characterization by two-dimensional immunoelectrophoresis with heparin in the first dimensional gel layer revealed a distinct change in the electrophoretic mobility of the inhibitor preincubated with elastase compared to native antithrombin III. This indicates that heparin binding sites of antithrombin III are occupied or affected by the elastase-induced peptide bond cleavage(s). Granulocytic proteinase inhibitors (eglin, Bowman-Birk inhibitor) proved to be highly effective in preventing the antithrombin III inactivation by degradation due to elastase. It is assumed that at least part of the antithrombin III consumption in diseases such as septicemia or endotoxemia is due to proteolysis by granulocytic proteinases. Application of specific inhibitors in the early phase of these ailments should be able to prevent this unspecific degradation of the endogenous antithrombin III.
A modular architecture for very large packet switches (2003)

The author proposes a modular architecture for very large packet switches, where each switch consists of a Batcher sorting network, a stack of binary trees, and a bundle of banyan networks. The modular architecture is a unification of the Batcher-banyan switch and the knockout switch, and it can be physically realized as an array of three-dimensional parallel processors. Switch modules are interconnected only at the outputs of multiplexers. The modularity implies less-stringent synchronization requirements and makes higher-speed implementation possible. Nonblocking and self-routing properties of Batcher-banyan switches are used to simplify the switch operation and to avoid the internal flow control problem. Also described is an extended ring reservation algorithm for contention resolution and output space extension. The proposed modular switch is intended to meet the needs of broadband telephone offices of all sizes. The author estimates that a modular switch with terabit capacity can be built with current VLSI technologies.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
C‐terminal neurogranin is increased in cerebrospinal fluid but unchanged in plasma in Alzheimer's disease (2015)

This study strengthens the potential of neurogranin as an AD CSF biomarker, which now needs validation in larger studies. As tools, straightforward immunoassays can be used, as demonstrated by the described ELISA.
Exploring sequence-function space of a poplar glutathione transferase using designed information-rich gene variants (2017)

Exploring the vicinity around a locus of a protein in sequence space may identify homologs with enhanced properties, which could become valuable in biotechnical and other applications. A rational approach to this pursuit is the use of 'infologs', i.e. synthetic sequences with specific substitutions capturing maximal sequence information derived from the evolutionary history of the protein family. Ninety-five such infolog genes of poplar glutathione transferase were synthesized and expressed in Escherichia coli, and the catalytic activities of the proteins determined with alternative substrates. Sequence-activity relationships derived from the infologs were used to design a second set of 47 infologs in which 90% of the members exceeded wild-type properties. Two mutants, C2 (V55I/E95D/D108E/A160V) and G5 (F13L/C70A/G122E), were further functionally characterized. The activities of the infologs with the alternative substrates 1-chloro-2,4-dinitrobenzene and phenethyl isothiocyanate, subject to different chemistries, were positively correlated, indicating that the examined mutations were affecting the overall catalytic competence without major shift in substrate discrimination. By contrast, the enhanced protein expressivity observed in many of the mutants were not similarly correlated with the activities. In conclusion, small libraries of well-defined infologs can be used to systematically explore sequence space to optimize proteins in multidimensional functional space.
Perineuronal nets decrease membrane capacitance of peritumoral fast spiking interneurons in a model of epilepsy (2018)

Brain tumor patients commonly present with epileptic seizures. We show that tumor-associated seizures are the consequence of impaired GABAergic inhibition due to an overall loss of peritumoral fast spiking interneurons (FSNs) concomitant with a significantly reduced firing rate of those that remain. The reduced firing is due to the degradation of perineuronal nets (PNNs) that surround FSNs. We show that PNNs decrease specific membrane capacitance of FSNs permitting them to fire action potentials at supra-physiological frequencies. Tumor-released proteolytic enzymes degrade PNNs, resulting in increased membrane capacitance, reduced firing, and hence decreased GABA release. These studies uncovered a hitherto unknown role of PNNs as an electrostatic insulator that reduces specific membrane capacitance, functionally akin to myelin sheaths around axons, thereby permitting FSNs to exceed physiological firing rates. Disruption of PNNs may similarly account for excitation-inhibition imbalances in other forms of epilepsy and PNN protection through proteolytic inhibition may provide therapeutic benefits.
Présentation (1990)

Présentation : l’oubli de l’espace dans le Plan d’organisation de services. Un article de la revue Santé mentale au Québec (Le réel et la mort dans la situation thérapeutique) diffusée par la plateforme Érudit.
Molecular and cellular studies of tryptophanyl‐tRNA synthetases using monoclonal antibodies (1989)

The content of Trp-tRNA synthetase in pancreas and liver of cattle, sheep, swine, rat, rabbit and man was assayed by direct radioimmunoblotting with a 125I-labelled monoclonal antibody Am1, specifically interacting with any eukaryotic Trp-tRNA synthetase. Its content in the organs studied, with the exception of bovine and sheep pancreas, was found to be 0.002-0.012% of total proteins. The enzyme content in bovine pancreas was about 0.2% of total proteins, i.e. 70 times higher than in bovine liver; similar correlations were found for sheep. The Trp-tRNA synthetase levels in each organ varied from animal to animal of the same species by not more than a factor of four; these individual variations cannot affect the conclusion about the profound differences in the levels of the enzyme in pancreases of Ruminantia and of the other mammalians. As shown by indirect immunofluorescence technique, bovine Trp-tRNA synthetase is mainly located in the exocrine part of the pancreas. Moreover, the immunoreactive material is detectable also in bovine (not human) pancreatic juice. The abnormally high Trp-tRNA synthetase content in the ruminant pancreas may be connected with unknown function(s) of this protein somehow related to the peculiarities of digestion of these mammals.
TTEthernet Dataflow Concept (2009)

TTEthernet is a novel communication infrastructures that allows using a single physical communication infrastructure for distributed applications with mixed-criticality requirements, e.g. the command and control systems and audio/video systems. This is achieved via a fault-tolerant self-stabilizing synchronization strategy, which establishes temporal partitioning and, hence, ensures isolation of the critical dataflows from the non-critical dataflows. The focus in this paper is on the dataflow in TTEthernet. For this we take the synchronization as a given and discuss from a TTEthernet user perspective which communication options TTEthernet provides and how they are aligned and realized. While this paper uses TTEthernet as reference communication infrastructure, the methods and strategies presented are valid for any message-based network.
Recognition via Sparse Representation: Robustness, Occlusion, and Feature Selection (2007)

This technical report combines two commonly-themed submissions to ICCV 2007. The two papers reconsider several fundamental problems in recognition from the perspective of sparsity. The representation sought by recognition systems is inherently sparse, since the test image should ideally be interpreted only in terms of training images of the same object. Our algorithms exploit this sparsity, classifying a test image based on a sparse representation in terms of the training images, computed via l1-minimization.\n\nThe ﬁrst of the two papers investigates the implications of this framework for feature selection. We show that, in agreement with the theory of compressive sensing, if sparsity is properly enforced, the choice of features is no longer critical. What is critical is that the number of features is sufﬁcient and that the sparse representation is properly found. In this context, highly accurate recognition is possible using severely down sampled images or even randomly generated features!\n\nThe second paper shows how robust recognition in the presence of occlusion can also be cast as a sparse representation problem. Here, our algorithm represents the test image as a sparse linear combination of the training images, plus a sparse error due to occlusion. The representation is efﬁciently and effectively computed by l1-minimization. We investigate the implications of this framework for the engineering of recognition systems showing how to predict how much occlusion the algorithm can tolerate, and how to choose the training data to maximize robustness.
Human Lyme Disease Vaccines: Past and Future Concerns (2009)

The development of a vaccine for Lyme disease was intensely pursued in the 1990s. However, citing a lack of demand, the first human Lyme disease vaccine was withdrawn from the market less than 5 years after its approval. The public's concerns about the vaccine's safety also likely contributed to the withdrawal of the vaccine. Nearly a decade later, no vaccine for human Lyme disease exists. The expansion of Lyme disease's endemic range, as well as the difficulty of diagnosing infection and the disease's steady increase in incidence in the face of proven preventative measures, make the pursuit of a Lyme disease vaccine a worthwhile endeavor. Many believe that the negative public perception of the Lyme disease vaccine will have tarnished any future endeavors towards its development. Importantly, many of the drawbacks of the Lyme disease vaccine were apparent or foreseeable prior to its approval. These pitfalls must be confronted before the construction of a new, effective and safe human Lyme disease vaccine.
Estimation of Ultraviolet Radiation Dose Using CaF2:Tb Phosphor (1996)

To observe and estimate the dose of ultraviolet (UV) radiation in sunlight, the available thermoluminescence (TL) materials were studied. Several kinds of lanthanide elements were doped in pure CaF2 powdered crystals and the properties of the TL for UV were observed. The TL intensity from CaF2Tb was the highest among the samples doped with various lanthanide elements, and from the TL emission spectra (380-540 nm) the TL is estimated to be due to inner transition of Tb3+. The peak wavelength of the TL excitation light was located approximately at 235 nm and light of a longer wavelength than 320 nm was unable to excite the TL. The ultraviolet response of CaF2:Tb depended on its sintering temperature. Even without ? ray pre-irradiation the CaF2:Tb sample with 1 h exposure to sunlight has enough sensitivity to estimate the change of UV. Seasonal change of UV intensity in sunlight was measured with this TLD during four months in 1993. The results agreed with that of other institutes in Japan.
La política científica desde una perspectiva histórica (1992)

La politica cientifica es reconocida, desde hace ya tiempo, como una especialidad imprescindible en toda nacion desarrollada que aspire a mantener un nivel cientifico adecuado, necesario, a su vez, para conservar su competitividad industrial. Espana no es una excepcion a tal regla. Ahora bien, no es extrano que en una nacion con escasa tradicion de politica cientifica esta especialidad se entienda en formas excesivamente limitadas.
Synthesis and Characterization of Polyurethane‐Based Shape‐Memory Polymers for Tailored <i>T</i><sub>g</sub> around Body Temperature for Medical Applications (2011)

Abstract Various polyurethane‐based SMPUs were synthesized using five types of polyols as soft segments and two different diisocyanates as hard segments. The effects of diisocyanate concentration on material properties such as crystallinity, transition temperature, shape‐memory effect and tensile strength were investigated. SMPUs with a maximum strain near 1 000%, recovery rate up to ≈98%, fixity up to ≈90% and T g s of 35–45 °C were obtained. A high MDI content results in SMPUs with better shape‐memory effect, whereas increasing IPDI content leads to a weaker shape‐memory effect. High IPDI concentration seems to prevent or restrict chemical reactions and crosslinks between the polyols and the hard segments, leading to large phase separation and coexistence of soft and hard segments in the macrophases. magnified image
Parsing with C++ deferred expressions (1994)

A technique for constructing embedded grammar-based parsers in C++ was described in [1]. This paper presents an extension to that technique which allows parsing actions to be specified directly as part of the grammar, rather than indirectly (as function calls).
Mechanical harvesting of black corinth raisins (1970)

The Black Corinth (Zante Currant) is a specialty raisin produced in the central San Joaquin Valley. Its main popularity is with the baking trade where the small, fruity, and tender raisin is ideal. Traditionally, the grapes have been hand picked and dried on trays in the vineyard. The variety has the advantage of being the earliest ripening and harvested raisin variety. However, hand harvest is difficult and costly because the clusters are small and the berries fragile. Pickers too often smash berries and cause juicing on the tray, and understandably complain about the numerous small clusters they must harvest.
Consolidation and Mechanical Properties of Gas Atomized Al-Si Powder (2007)

Hypereutectic prealloyed Al-20wt.%Si powders were prepared by the gas atomization process. Characteristics of the atomized Al-Si powders were investigated. With increasing gas pressure of the atomization, the average powder size and oxygen content decreased. Primary Si particles in the as-atomized powders were about 8-10 ㎛. Sintering behavior of the atomized Al-Si powders was discussed with sintering temperature. As-atomized powders were hot-pressed and extruded into a cylindrical shape. 96-99% of theoretical density was achieved by the hot consolidation. Microstructure changes as well as hardness and tensile properties of the samples were evaluated in this paper.
WaterML2.0: Enabling water information exchange (2011)

Our ability to share and understand water information from various sources is currently limited by the use of incompatible information management and publication technologies. Water management bodies, hydropower companies, meteorologists and other interested stakeholders all monitor water resources and store their data using a wide array of technologies. Standards are multi-party agreements that provide a common ground on which people can share information by minimising ambiguity and sharing definitions for domain concepts. They are most effective when surrounded by an active community who, along with taking part in defining such concepts, develop supporting tools that allow for easy transmission and interpretation of data sets.
Neural RGB®D Sensing: Depth and Uncertainty From a Video Camera (2019)

Depth sensing is crucial for 3D reconstruction and scene understanding. Active depth sensors provide dense metric measurements, but often suffer from limitations such as restricted operating ranges, low spatial resolution, sensor interference, and high power consumption. In this paper, we propose a deep learning (DL) method to estimate per-pixel depth and its uncertainty continuously from a monocular video stream, with the goal of effectively turning an RGB camera into an RGB-D camera. Unlike prior DL-based methods, we estimate a depth probability distribution for each pixel rather than a single depth value, leading to an estimate of a 3D depth probability volume for each input frame. These depth probability volumes are accumulated over time under a Bayesian filtering framework as more incoming frames are processed sequentially, which effectively reduces depth uncertainty and improves accuracy, robustness, and temporal stability. Compared to prior work, the proposed approach achieves more accurate and stable results, and generalizes better to new datasets. Experimental results also show the output of our approach can be directly fed into classical RGB-D based 3D scanning methods for 3D scene reconstruction.
Adjunctive periodontal treatment with Centella asiatica and Punica granatum extracts. A preliminary study. (2003)

The results indicate that local delivery with C. asiatica and P. granatum extracts plus scaling and root planing significantly reduced the clinical signs of chronic periodontitis.
Templated Nanocrystal-Based Porous TiO<sub>2</sub> Films for Next-Generation Electrochemical Capacitors (2009)

The advantages in using nanoscale materials for electrochemical energy storage are generally attributed to short diffusion path lengths for both electronic and lithium ion transport. Here, we consider another contribution, namely the charge storage from faradaic processes occurring at the surface, referred to as pseudocapacitive effect. This paper describes the synthesis and pseudocapacitive characteristics of block copolymer templated anatase TiO(2) thin films synthesized using either sol-gel reagents or preformed nanocrystals as building blocks. Both materials are highly crystalline and have large surface areas; however, the structure of the porosity is not identical. The different titania systems are characterized by a combination of small- and wide-angle X-ray diffraction/scattering, combined with SEM imaging and physisorption measurements. Following our previously reported approach, we are able to use the voltammetric sweep rate dependence to determine quantitatively the capacitive contribution to the current response. Considerable enhancement of the electrochemical properties results when the films are both made from nanocrystals and mesoporous. Such materials show high levels of capacitive charge storage and high insertion capacities. By contrast, when mesoscale porosity is created in a material with dense walls (rather than porous walls derived from the aggregation of nanocrystals), insertion capacities comparable to templated nanocrystal films can be achieved, but the capacitance is much lower. The results presented here illustrate the importance of pseudocapacitive behavior that develops in high surface area mesoporous oxide films. Such systems provide a new class of pseudocapacitive materials, which offer increased charge storage without compromising charge storage kinetics.
The Use of Autologous Platelet-Rich Plasma (Platelet Gel) and Autologous Platelet-Poor Plasma (Fibrin Glue) in Cosmetic Surgery (2001)

The purpose of this study was to evaluate a new technique of harvesting and preparing autologous platelet gel and autologous fibrin glue (body glue) and to evaluate their effectiveness in stopping capillary bleeding in the surgical flaps of patients undergoing cosmetic surgery. A convenience sample of 20 patients ranging from 25 to 76 years of age undergoing cosmetic surgery involving the creation of a surgical flap were included in the study. The types of surgical procedures included face lifts, breast augmentations, breast reductions, and neck lifts. Plateletpoor and platelet-rich plasma were prepared during the procedure from autologous blood using a compact, tabletop, automated autologous platelet concentrate system (SmartPReP, Harvest Autologous Hemobiologics, Norwell, Mass.). The platelet-poor and platelet-rich plasma were combined with a thrombin-calcium chloride solution to produce autologous fibrin glue and autologous platelet gel, respectively. Capillary bed bleeding was present in all cases and effectively sealed within 3 minutes following the application of platelet gel and fibrin glue. The technique for making the solution and for evaluating its effectiveness in achieving and maintaining hemostasis during cosmetic surgical procedures is described. Autologous platelet gel and fibrin glue prepared by the automated concentrate system are compared with autotransfusor-prepared platelet gel and Tisseel (Baxter Healthcare Corp.), a commercially prepared fibrin sealant preparation. (Plast. Reconstr. Surg. 107: 229, 2001.)
Recombinant λ-phage nanobioparticles for tumor therapy in mice models (2010)

Lambda phages have considerable potential as gene delivery vehicles due to their genetic tractability, low cost, safety and physical characteristics in comparison to other nanocarriers and gene porters. Little is known concerning lambda phage-mediated gene transfer and expression in mammalian hosts. We therefore performed experiments to evaluate lambda-ZAP bacteriophage-mediated gene transfer and expression in vitro. For this purpose, we constructed recombinant lambda-phage nanobioparticles containing a mammalian expression cassette encoding enhanced green fluorescent protein (EGFP) and E7 gene of human papillomavirus type 16 (lambda-HPV-16 E7) using Lambda ZAP- CMV XR vector. Four cell lines (COS-7, CHO, TC-1 and HEK-239) were transduced with the nanobioparticles. We also characterized the therapeutic anti-tumor effects of the recombinant lambda-HPV-16 E7 phage in C57BL/6 tumor mice model as a cancer vaccine. Obtained results showed that delivery and expression of these genes in fibroblastic cells (COS-7 and CHO) are more efficient than epithelial cells (TC-1 and HEK-239) using these nanobioparticles. Despite the same phage M.O.I entry, the internalizing titers of COS-7 and CHO cells were more than TC-1 and HEK-293 cells, respectively. Mice vaccinated with lambda-HPV-16 E7 are able to generate potent therapeutic antitumor effects against challenge with E7- expressing tumor cell line, TC-1 compared to group treated with the wild phage. The results demonstrated that the recombinant lambda-phages, due to their capabilities in transducing mammalian cells, can also be considered in design and construction of novel and safe phage-based nanomedicines.
High-Dose Intravenous Methylprednisolone Therapy for Pain in Children and Adolescents with Sickle Cell Disease (1994)

The management of episodes of severe pain in patients with sickle cell disease is a difficult clinical problem. We studied 36 children and adolescents with sickle cell disease who had 56 acute episodes of severe pain (44 in 27 patients with sickle cell anemia, 8 in 7 patients with sickle cell-hemoglobin C disease, and 4 in 2 patients with sickle cell-β+-thalassemia). The patients were randomly assigned in double-blind fashion to receive an intravenous infusion of either saline placebo or high-dose methylprednisolone (15 mg per kilogram of body weight, to a maximum of 1000 mg) on their admission to the hospital and again 24 hours later. All the patients received intravenous morphine sulfate until severe pain abated and were then given acetaminophen with codeine.