gebhart/patrepeval huggingface dataset:
The Structure of a Retinal-Forming Carotenoid Oxygenase (2005)

Enzymes that produce retinal and related apocarotenoids constitute a sequence- and thus structure-related family, a member of which was analyzed by x-ray diffraction. This member is an oxygenase and contains an Fe2+-4-His arrangement at the axis of a seven-bladed beta-propeller chain fold covered by a dome formed by six large loops. The Fe2+ is accessible through a long nonpolar tunnel that holds a carotenoid derivative in one of the crystals. On binding, three consecutive double bonds of this carotenoid changed from a straight all-trans to a cranked cis-trans-cis conformation. The remaining trans bond is located at the dioxygen-ligated Fe2+ and cleaved by oxygen.
PP.23.25 (2015)

Objective: Adrenal venous sampling(AVS) is recommended as the gold standard procedure for subtype classification in PA, but the procedure is challenging and the right adrenal vein (RAV) particularly difficult to cannulate because it is short, variable and enters the inferior vena cava (IVC) at an acute angle. Our purpose was to find a feasible method in right adrenal venous cannulation by using MDCT with three dimensional reconstruction before AVS. Design and method: From August 2013 to April 2014, a total of 20 patients with confirmed PA who had a unilateral or bilateral adrenal morphology abnormalities (including Hyperplasia or adenoma which diameter <1 cm) underwent AVS were analyzed retrospectively.7 of the patients used MDCT with 3 dimensional before AVS, the other 13 patients without using MDCT with 3 dimensional before AVS served as controls. To compare the rate of correct cannulation, contrast volume used, and time of right adrenal venous sampling between two groups above. Successful adrenal vein catheterization is defined by a ratio of >3:1 of cortisol in the adrenal vein vs the inferior vena cava. Results: As compared to controls, using MDCT with three dimensional reconstruction before AVS increased the rate of correct cannulation into RAV from 23.1% to 85.7% (p < 0.05), decreased the contrast volume about 1/3 (23 ± 4 vs60 ± 18, p < 0.05) and shortened the time to identify RAV by 50%(14.2 ± 3.1 vs 29.7 ± 6.8, p < 0.05). By contrast MDCT with three dimensional reconstruction and angiography,7 patients catheter misplacement lead to failure of right adrenal venous sampling before using MDCT. Conclusions: MDCT with three dimensional reconstruction used before AVS might provide visual confirmation of correct cannulation, decrease the contrast volume, shorten the time to identify RAV, and improve success rates of RAV sampling.
Topical ambroxol for the treatment of neuropathic pain (2015)

Ambroxol acts as a strong local anaesthetic and preferentially inhibits the nociceptively relevant sodium channel subtype Nav 1.8. For the first time, we report below on a relevant pain relief following topical ambroxol 20% cream in patients with neuropathic pain. In view of the positive side effect profile, the clinical benefit in patients with pain should be investigated further.
Stimulated Raman scattering-induced baseband video distortion due to 1.65-μm OTDR online monitoring in 1.55-μm AM-VSB CATV system (2002)

We investigated the online monitoring of a 1.55-μm amplitude-modulation vestigial-sideband CATV video transport system using a 1.65-μm optical time-domain reflectometer (OTDR). The baseband video-picture distortion resulting from the stimulated Raman scattering interaction between the AM video signals and the OTDR pulses in the single-mode fiber link is observed and analyzed.
Pyridonecarboxylic Acids as Antibacterial Agents. V (1986)

A series of 7-amino derivatives (unsubstituted and substituted piperazine, pyrrolidine and piperidine) of 1-aryl-6-fluoro-4-oxo-1, 8-naphthyridine-3-carboxylic acid (aryl=4-fluoro-, 2, 4-difluoro-and 3, 4-difluorophenyl) has been prepared, and their antibacterial activity and urinary recovery in mice were evaluated. All compounds (6a-h, 7a-h, 8a) showed better in vitro antibacterial activity than the quinolone counterparts described in the preceding paper and especially 7-(3-amino-1-pyrrolidinyl)-1-(4-fluorophenyl) and -1-(2, 4-difluorophenyl) derivatives (6e and 7e) showed a noteworthy excellent activity against S. aureus (minimum inhibitory concentration<0.05μg/ml) as well as gram-negative bacteria. Among the four selected compounds (6a, e and 7a, e) for the estimation of in vivo efficacy on systemic infections and acute toxicity, 7e was the best compound [ED 50 (mg/mouse, p. o.): vs. S. aureus SA-57, 0.013; vs. S. marcescens IID 620, 0.008]. Structure-activity relationship concerning 7-amino groups is also discussed.
Selectivity Map for Molecular Beam Epitaxy of Advanced III–V Quantum Nanowire Networks (2018)

Selective-area growth is a promising technique for enabling of the fabrication of the scalable III-V nanowire networks required to test proposals for Majorana-based quantum computing devices. However, the contours of the growth parameter window resulting in selective growth remain undefined. Herein, we present a set of experimental techniques that unambiguously establish the parameter space window resulting in selective III-V nanowire networks growth by molecular beam epitaxy. Selectivity maps are constructed for both GaAs and InAs compounds based on in situ characterization of growth kinetics on GaAs(001) substrates, where the difference in group III adatom desorption rates between the III-V surface and the amorphous mask area is identified as the primary mechanism governing selectivity. The broad applicability of this method is demonstrated by the successful realization of high-quality InAs and GaAs nanowire networks on GaAs, InP, and InAs substrates of both (001) and (111)B orientations as well as homoepitaxial InSb nanowire networks. Finally, phase coherence in Aharonov-Bohm ring experiments validates the potential of these crystals for nanoelectronics and quantum transport applications. This work should enable faster and better nanoscale crystal engineering over a range of compound semiconductors for improved device performance.
Metabolism of 2-chloro-N-isopropylacetanilide (propachlor) in the leaves of corn, sorghum, sugarcane, and barley (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMetabolism of 2-chloro-N-isopropylacetanilide (propachlor) in the leaves of corn, sorghum, sugarcane, and barleyGerald L. Lamoureux, Lester E. Stafford, and Fred S. TanakaCite this: J. Agric. Food Chem. 1971, 19, 2, 346–350Publication Date (Print):March 1, 1971Publication History Published online1 May 2002Published inissue 1 March 1971https://pubs.acs.org/doi/10.1021/jf60174a011https://doi.org/10.1021/jf60174a011research-articleACS PublicationsRequest reuse permissionsArticle Views113Altmetric-Citations71LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Diels‐alder cycloadditions of diene‐substituted <i>N</i>‐ethoxycarbonyl‐2‐methyl‐1,2‐dihydropyridines with <i>N</i>‐phenylmaleimide (1985)

Abstract The ten possible substitution patterns for N ‐Ethoxycarbonyl‐2‐methyl‐1,2‐dihydropyridines 5 in which one or two olefinic sites are alkyl substituted were synthesized and reacted with N ‐phenylmaleimide 2 to provide cycloadducts 6. N ‐Ethoxycarbonyl‐5,6‐cyclohexyl‐2‐methyl‐1,2‐dihydropyridine 51 provided the novel spirocycle 61.
A Novel Cell Delivery System Using Magnetically Labeled Mesenchymal Stem Cells and an External Magnetic Device for Clinical Cartilage Repair (2007)

Our novel approach is applicable for human cartilage defects and may open a new era of repairing cartilage defects caused by osteoarthritis or trauma by use of a less invasive technique.
The Preparation of Glycerophenylose Enedioldiacetate<sup>*</sup> (1941)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Preparation of Glycerophenylose Enedioldiacetate*Wm. G. Dauben, Wm. Lloyd Evans, and Robert I. MeltzerCite this: J. Am. Chem. Soc. 1941, 63, 7, 1883–1885Publication Date (Print):July 1, 1941Publication History Published online1 May 2002Published inissue 1 July 1941https://pubs.acs.org/doi/10.1021/ja01852a022https://doi.org/10.1021/ja01852a022research-articleACS PublicationsRequest reuse permissionsArticle Views91Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Bone disease in rheumatoid arthritis (1988)

Other| March 01 1988 Bone disease in rheumatoid arthritis P. N. Sambrook; P. N. Sambrook 1Garvan Institute of Medical Research and Department of Rheumatology, St Vincent's Hospital, Sydney, Australia Search for other works by this author on: This Site PubMed Google Scholar J. Reeve J. Reeve 2Bone Disease Research Group, MRC Clinical Research Centre and Northwick Park Hospital, Harrow, Middx., U.K. Search for other works by this author on: This Site PubMed Google Scholar Clin Sci (Lond) (1988) 74 (3): 225–230. https://doi.org/10.1042/cs0740225 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation P. N. Sambrook, J. Reeve; Bone disease in rheumatoid arthritis. Clin Sci (Lond) 1 March 1988; 74 (3): 225–230. doi: https://doi.org/10.1042/cs0740225 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsClinical Science Search Advanced Search © 1970 The Biochemical Society and the Medical Research Society1970 Article PDF first page preview Close Modal You do not currently have access to this content.
An embedded barcode for “connected” malaria rapid diagnostic tests (2017)

Many countries are shifting their efforts from malaria control to disease elimination. New technologies will be necessary to meet the more stringent demands of elimination campaigns, including improved quality control of malaria diagnostic tests, as well as an improved means for communicating test results among field healthcare workers, test manufacturers, and national ministries of health. In this report, we describe and evaluate an embedded barcode within standard rapid diagnostic tests as one potential solution. This information-augmented diagnostic test operates on the familiar principles of traditional lateral flow assays and simply replaces the control line with a control grid patterned in the shape of a QR (quick response) code. After the test is processed, the QR code appears on both positive or negative tests. In this report we demonstrate how this multipurpose code can be used not only to fulfill the control line role of test validation, but also to embed test manufacturing details, serve as a trigger for image capture, enable registration for image analysis, and correct for lighting effects. An accompanying mobile phone application automatically captures an image of the test when the QR code is recognized, decodes the QR code, performs image processing to determine the concentration of the malarial biomarker histidine-rich protein 2 at the test line, and transmits the test results and QR code payload to a secure web portal. This approach blends automated, sub-nanomolar biomarker detection, with near real-time reporting to provide quality assurance data that will help to achieve malaria elimination.
DUAL TASK PERFORMANCE AND PROCESSING RESOURCES IN NORMAL SUBJECTS AND PATIENTS WITH PARKINSON'S DISEASE (1991)

In recent years, there has been a growing consensus among investigators that the presence or absence of external cues guiding behaviour and attention is an important factor in determining whether or not deficits are found in patients with Parkinson's disease (PD). In an earlier study, the authors suggested that the pattern of impaired and intact performance could be explained in terms of differential resource demands of the tasks, combined with depleted levels of central processing resources in PD patients. Two experiments are reported, both employing dual-task paradigms. The first assessed, in normal subjects, the relative processing demands of a cued and an uncued version of the Stroop task. The results supported the proposal that the noncued task made greater demands on the subject's limited processing resources. Further, performing a resource demanding secondary task concurrently with the Stroop test produced, in normal subjects, the same pattern of impaired performance as that reported previously in PD patients. In the second experiment the same dual-task paradigm was employed with a group of PD patients and normal aged-matched controls. Only the patients showed an increase in reaction time on the Stroop task when performing a resource demanding secondary task. The patients also showed an interfering effect with concurrent foot tapping but not with an articulatory suppression task. The results were taken to support the hypothesis that PD patients have depleted central processing resources. In considering the present data, alternative explanations for the results are considered, in particular the possibility that they represent a deficit in switching processing resources between two tasks as the combined demands outweigh available resources.
Feedback Regulation of Arginine Biosynthesis in Blue-Green Algae and Photosynthetic Bacteria (1966)

Hoare, D. S. (The University of Texas, Austin), and S. L. Hoare. Feedback regulation of arginine biosynthesis in blue-green algae and photosynthetic bacteria. J. Bacteriol. 92:375-379. 1966.-A number of blue-green algae and photosynthetic bacteria synthesize arginine from glutamate via acetylated intermediates. Cell-free extracts of these photosynthetic microorganisms contain an N-acetyl glutamate phosphokinase, which is specifically inhibited by arginine. They also contain a transacetylase which forms ornithine from alphaN-acetyl ornithine and glutamate. The transacetylase appears to be specific for l-glutamate. Arginine synthesis and its regulation by feedback inhibition in photosynthetic microorganisms differ from that in Escherichia coli and other Enterobacteriaceae.
Raman spectroscopy of carbon materials: structural basis of observed spectra (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRaman spectroscopy of carbon materials: structural basis of observed spectraYan Wang, Daniel C. Alsmeyer, and Richard L. McCreeryCite this: Chem. Mater. 1990, 2, 5, 557–563Publication Date (Print):September 1, 1990Publication History Published online1 May 2002Published inissue 1 September 1990https://pubs.acs.org/doi/10.1021/cm00011a018https://doi.org/10.1021/cm00011a018research-articleACS PublicationsRequest reuse permissionsArticle Views10623Altmetric-Citations1401LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Biotransformation enzymes in human intestine: critical low levels in the colon? (1991)

Biotransformation or drug-metabolising enzymes have an important function in the detoxication of ingested toxic, carcinogenic, or tumour promoting compounds. Enzyme activity and isoenzyme composition of three biotransformation systems: glutathione S-transferase, uridine diphosphate-glucuronosyltransferase, and cytochrome P-450 were studied in normal small and large intestinal mucosa from three kidney donors. The activity of most drug-metabolising enzymes decreases slightly from proximal to distal small intestine, whereas in the mucosa of the large intestine a sharp fall in activity was observed. The isoenzyme composition for each of the three biotransformation systems changed from the small to the large intestine. Class Alpha glutathione S-transferases were not expressed in the colon, in contrast to the small intestine where both Alpha and Pi class isoenzymes are present. In addition, with monoclonal antibodies fewer protein bands for UDP-glucuronosyltransferases and cytochrome P-450 were detected in the colon. In the small intestine both isoforms P-450(4) and P-450(5) were present, whereas in the colon only reduced amounts of cytochrome P-450(4) could be visualised. For UDP-glucuronosyltransferase, 53 and 54 kDa proteins could be detected in the small intestine, but in the colon there was only weak staining of the 54 kDa band. In the normal human colon enzymes are less active and there are fewer isoenzymes present in the mucosa than in the small intestine. This implies a lower level of the detoxifying potential in the colon, which might be important in regard to the high rates of carcinogenesis in the colon.
Industry track: a rule engine for location based content syndication (2004)

Location-based services (LBS) play an increasing role in mobile systems and applications. In this paper we focus on LBS in a multi-provider network. Using multiple providers reduces dependencies, increases geographic and functional coverage, and allows distribution, load balancing, and fail-over. However, the framework must ensure substitutability of services. We describe the use of a rule engine to dynamically determine a near-optimal provider for each request. The choice is based on performance, reliability, geographic coverage, as well as more intangible considerations. Overall performance, coverage, and distribution can thus be increased at the framework-level.
The pathways of glutamate and glutamine oxidation by tumor cell mitochondria. Role of mitochondrial NAD(P)+-dependent malic enzyme. (1984)

Little evidence has been available on the oxidative pathways of glutamine and glutamate, the major respiratory substrates of cancer cells. Glutamate formed from glutamine by phosphate-dependent glutaminase undergoes quantitative transamination by aerobic tumor mitochondria to yield aspartate. However, when malate is also added there is a pronounced decrease in aspartate production and a large formation of citrate and alanine, in both state 3 and 4 conditions. In contrast, addition of malate to normal rat heart, liver, or kidney mitochondria oxidizing glutamate causes a marked increase in aspartate production. Further analysis showed that extramitochondrial malate is oxidized almost quantitatively to pyruvate + CO2 by NAD(P)+-linked malic enzyme, present in the mitochondria of all tumors tested, but absent in heart, liver, and kidney mitochondria. On the other hand intramitochondrial malate generated from glutamate is oxidized quantitatively to oxalacetate by mitochondrial malate dehydrogenase of tumors. Acetyl-CoA derived from extramitochondrial malate via pyruvate and oxalacetate derived from glutamate via intramitochondrial malate are quantitatively converted into citrate, which is extruded. No evidence was found that malic enzyme of tumor mitochondria converts glutamate-derived malate into pyruvate as postulated in other reports. Possible mechanisms for the integration of mitochondrial malic enzyme and malate dehydrogenase activities in tumors are discussed.
The Physical Properties of Fluorine Derivatives of 4-Cyanobiphenyls (1985)

Abstract The physical properties of two new series of liquid crystalline materials, the 2- and 2′-fluoro-substituted derivatives of the 4-n-alkyl-4′-cyanobiphenyls, have been examined and compared to their unfluorinated analogues. The presence of the lateral fluorine substituent is found to suppress both the injected smectic phases found in the hybrid mixtures with esters, which are designed for use in multiplexed displays, and the strong anti-paraliel correlations normally present in cyanobiphenyls.
The effects of melatonin on the behavioural disturbances induced by chronic mild stress in C3H/He mice (1999)

In rodents, exposure to chronic mild stress (CMS) is known to induce unresponsiveness to environmental stimuli, as well as sleep disturbances, suggesting some analogies between this syndrome and human depression. Furthermore, numerous studies reported a decrease in nocturnal melatonin concentration in depressed patients, compared with controls. The present study was conducted to test a possible preventative action of daily treatment with melatonin on behavioural alterations induced in C3H/He mice by CMS exposure. In addition to daily spontaneous locomotor activity and preference for sucrose solution, the emotional behaviour of mice was examined in a stressful situation (light/dark choice test), as well as in a situation devoid of constraining components (free-exploratory paradigm), after three weeks of CMS. The results showed that the behaviour of C3H/He mice was disrupted after CMS. Stressed mice exhibited blunted emotional reactivity in both the light/dark choice test and the free-exploratory situation. While unstressed mice presented no variation in their preference for a sucrose solution, stressed mice presented a decrease in such preference towards the end of the CMS exposure. Furthermore, daily spontaneous locomotor activity of the mice was reduced after CMS. Daily treatment of stressed mice with melatonin was able to prevent several CMS-induced disturbances, except in the light/dark choice test, where melatonin was ineffective. Compared to the effects of 10 mg/kg of fluoxetine, which completely prevented CMS-induced dysregulation of behaviour, melatonin was less effective. The present results support the idea that melatonin may be implicated in an homeostatic system which protects animals from disruptions induced by chronic stress.