gebhart/patrepeval huggingface dataset:
A reduced-complexity model for river delta formation – Part 1: Modeling deltas with channel dynamics (2015)

Abstract. In this work we develop a reduced-complexity model (RCM) for river delta formation (referred to as DeltaRCM in the following). It is a rule-based cellular morphodynamic model, in contrast to reductionist models based on detailed computational fluid dynamics. The basic framework of this model (DeltaRCM) consists of stochastic parcel-based cellular routing schemes for water and sediment and a set of phenomenological rules for sediment deposition and erosion. The outputs of the model include a depth-averaged flow field, water surface elevation and bed topography that evolve in time. Results show that DeltaRCM is able (1) to resolve a wide range of channel dynamics – including elongation, bifurcation, avulsion and migration – and (2) to produce a variety of deltas such as alluvial fan deltas and deltas with multiple orders of bifurcations. We also demonstrate a simple stratigraphy recording component which tracks the distribution of coarse and fine materials and the age of the deposits. Essential processes that must be included in reduced-complexity delta models include a depth-averaged flow field that guides sediment transport a nontrivial water surface profile that accounts for backwater effects at least in the main channels, both bedload and suspended sediment transport, and topographic steering of sediment transport.
Neuroprotection by Sodium Channel Blockade with Phenytoin in an Experimental Model of Glaucoma (2005)

Orally delivered phenytoin was effective in protecting neurons in an animal model of glaucoma, and merits further examination as a potential therapeutic strategy.
Rutting evaluation of dense graded hot mix asphalt mixture (2011)

Abstract — Rutting is one of the common pavement distresses which led to lower riding comfort for road users and high maintenance costs. One of the widely used tests is the simulation test using the wheel tracking device. In this study, efforts have been made to evaluate rutting of dense graded hot mix asphalt (HMA) using the dynamic modulus Simple Performance test (SPT). Granite aggregates from Klang Valley located in the central region of Peninsular Malaysia were used to produce the HMA mixtures with two different types of aggregate gradation designed using Superpave and Marshall mix design method. The rut evaluation was selected from SPT dynamic modulus test conducted at 40°C, 45°C and 50°C and 5 Hz, 2 Hz, 1 Hz and 0.5 Hz loading frequencies. Results from the study indicated that a correlation was found between the rut stiffness factor from SPT dynamic modulus test when tested at 5 Hz loading frequencies with temperature of 40°C, 45°C and 50°C and the rut depth from Wessex wheel tracking test. Keywords- hot mix asphalt; rutting; simple performance test; wheel tracking test R I.
Subtraction threshold for an isotropic fluorescence emission difference microscope (2015)

Isotropic fluorescence emission difference microscopy proposed recently provides a simple method to enhance the spatial resolution in three-dimensions (3D) for fluorescence imaging. However, the subtraction threshold to achieve the condition for appropriately resolving the sample in 3D have not been studied. Then the subtraction factors used in this type of microscopes are still experientially chosen. Based on vector diffraction theory and a 3D numerical model developed here, the subtraction threshold is numerically investigated for the isotropic fluorescence subtraction microscopy. The subtraction factors and peak intensities at the threshold are obtained and comparied both in lateral and axial planes for achieving most appropriate subtraction and inspecting the isotropic characteristic. The effects of radius ratios of implemented 0-π annular phase plate for generating three dimensional donut spot on the subtracted resolution, peak intensity and negative sidebands are also discussed.
Current results of balloon aortic valvuloplasty in high-risk patients. (2007)

In this report, we describe our experience with a contemporary series of patients with severe aortic stenosis (AS) undergoing balloon aortic valvuloplasty (BAV) who were not deemed to be surgical candidates. Demographic, hemodynamic and procedural data, operative risk (EuroSCORE) and long-term follow up were collected. Eighty consecutive patients with severe symptomatic AS underwent 104 BAV procedures as a single center and were followed for a mean of 3+/-2 years. Thirteen patients underwent 2 BAV procedures, 2 patients underwent 3 BAV procedures and 1 patient underwent 5 BAV procedures. Mean age was 81+/-10 years, and 23% were >90 years of age. Cardiogenic shock was present in 20% and the ejection fraction was <30% in 38% of the patients. The mean EuroSCORE was 16+/-5, and 98% had a high-risk EuroSCORE. There were no procedural deaths and 9 (9%) total vascular complications. In-hospital, 1-, 2- and 3-year mortality rates were 6%, 44%, 62% and 71%, respectively. Seventeen patients (21%) underwent repeat BAV procedures and had long-term mortality similar to those undergoing a single BAV procedure. Contemporary BAV has acceptable short- and long-term results and can effectively be used for patients deemed unsuitable surgical candidates and those at highest operative risk, such as patients with cardiogenic shock.
A hybrid approach to enhance task portability of acoustic models in Chinese speech recognition (2001)

This paper presents our approach to enhance the portability of acoustic models by mitigating the phonetic mismatch arising from a new testing task which is rather different from the training data. The approach is a hybrid one which combines knowledge-based context categorization to generate a context rich set of subword units, and data-driven-based acoustic model clustering on the level of context category. Compared with the conventional approach of only phonetic decision tree based model clustering and unseen model generation, the new approach improved greatly the desired subword coverage for the new testing domain, and achieved an error rate reduction by 10.8% for Chinese character accuracy in the recognition experiments. Together with the effect of the newly adopted basic units of 9 glottal stops, we achieved a total 23.5% error rate reduction in the testing compared to the baseline system.
[Preliminary screen of metastasis-related genes in cervical squamaous cell carcinoma]. (2013)

Gene profile in cervical squamous cell carcinoma tissues associated with pelvic lymph node metastasis is preliminarily identified, indicating that lymph node metastasis of cervical squamous cell carcinoma is a process involving numerous genes.
Quiescence-Inducing and Antiapoptotic Activities of IL-15 Enhance Secondary CD4+ T Cell Responsiveness to Antigen (1998)

IL-15 shows functional redundancy with IL-2 due to its usage of the beta and gamma c subunit of the IL-2R. Yet, the requirement of IL-15 for an IL-15R alpha chain for high affinity interaction and the separate cellular sources of IL-2 and IL-15 suggest divergent activities for both cytokines. We compared the growth-inducing and proapoptotic or antiapoptotic activities of IL-15 and IL-2 on mature CD4+ T lymphocytes in the presence or absence of TCR occupancy. We found that the nature of IL-15 activity was critically dependent on the activation status of the T cells. In the absence of TCR triggering, IL-15 did not exert the growth factor activity of IL-2, but induced a quiescent phenotype, characterized by maintenance of the cells in the G0/G1 phase of the cell cycle and down-regulation of CD25, CD71, and CD95 expression. In the presence of appropriate TCR engagement, the IL-15-induced quiescent T cells were resistant against TCR-induced cell death and proliferated strongly. IL-2-treated cells, on the contrary, were sensitized to cell death, resulting in a negative feedback on cellular expansion and weak proliferative responsiveness. Consecutive action of IL-15 during the distinct phases of an in vitro immune response markedly increased the cell output of a second antigenic stimulation, as compared with IL-2. These results imply that during immune reactivity in vivo, IL-15 may take over from the transiently available IL-2 the role of survival factor but not of growth factor, hence promoting the long term maintenance of resting, Ag-experienced CD4+ T cells.
Cloning of a Gene Encoding a Putative Xylanase with a Cellulose-Binding Domain from<i>Humicola grisea</i> (1997)

We have isolated a genomic clone of a putative xylanase gene (xyn1) from Humicola grisea by using the DNA fragment encoding a cellulose-binding domain of H. grisea cellobiohydrolase 1 as a probe. The translation product of the xyn1 gene predicts a xylanase of 429 amino acids in length, with a cellulose-binding domain in the C-terminus.
Effects of Chronic Administration of Sarpogrelate on Systolic Blood Pressure of Spontaneously Hypertensive Rats: Comparison with Quinapril (2002)

Effects of long-term sarpogrelate (5-HT(2) antagonist) administration on the systolic blood pressure of Wistar-Kyoto normotensive rats (WKYs) and spontaneously hypertensive rats (SHRs) were studied and compared with those of quinapril (ACE-I). Sarpogrelate and quinapril were administered orally for 12 weeks and body and heart weights, systolic blood pressure and the relationships between heart weight and systolic blood pressure were determined. Although both drug treatments caused decreases in the body weight of WKYs and SHRs, only quinapril induced a decrease in the heart weight of SHRs. In addition, quinapril induced a dose-dependent decrease in systolic blood pressure in WKYs and SHRs while sarpogrelate had no effect on systolic blood pressure. Thus, quinapril showed hemodynamic effects on WKYs and SHRs, but the 5-HT(2) antagonists sarpogrelate did not shown such effects, suggesting that 5-HT(2) receptor antagonists may not be important for controlling systolic blood pressure.
Thermoelectric semiconductor and electrode-fabrication and evaluation of SiGe/electrode (2002)

Joints between a silicon-germanium thermoelectric semiconductor and electrodes were prepared by hot-pressing. Tungsten or carbon electrodes were joined to either side of n-type Si/sub 0.8/Ge/sub 0.2/ (P 0.3 at.%) respectively, with thin sheets of titanium foil inserted between them, and then pressed and joined at 1523 K in vacuum. The size of the resulting electrode/SiGe semiconductor/electrode units measured 5 mm/spl times/ 5 mm/spl times/9 mm. Observations through SEM and EPMA showed the presence of many voids in the junction layers of the SiGe/tungsten electrodes, whereas the SiGe/carbon electrodes exhibited no voids in their junction layers. In the SiGe/carbon electrodes, the titanium atoms were enriched in the junction layer, and other atoms also remained undiffused. In the SiGe/tungsten electrodes, the tungsten and silicon atoms showed counter diffusion. Resistance and Seebeck coefficient of the carbon/SiGe/carbon electrodes were measured in the temperature range from 600 to 1100 K. Resistance ranged from 0.012 to 0.015 /spl Omega/, and the Seebeck coefficient from 200/spl times/10/sup -6/ to 250/spl times/10/sup -6/ V/K. To evaluate the upper limit of heating dependence, the carbon/SiGe/carbon electrodes were exposed in an argon atmosphere at 1273 K and 1373 K for 300 hours. After exposure testing, SEM observation showed the presence of many voids in the junction layer of the SiGe/carbon electrode, which had not previously shown any voids either at the stage of joining by hot-pressing or exposure at 1273 K.
Precursors to pre-eclampsia: are there markers in the fetal circulation? (2004)

One of the fundamental issues in pre-eclampsia (hypertension in pregnancy) research is to find serum proteins that can act as markers of disease predisposition, remote disease onset, imminent disease onset or disease activity at the height of its destructive powers. We make assumptions, not infrequently, that positive findings at the time of delivery reflect early changes in the maternal and fetal circulations. Very little has been defined in terms of fetal circulation, as it is, by and large, deemed to be harder to access and less likely to lend itself to useful non-invasive diagnostic tests in early pregnancy. The study published in this issue of Clinical Science by Prickett et al. shows that there is a differential expression of the precursor molecule of CNP (C-type natriuretic peptide), N-terminal proCNP, in pre-eclampsia. At term, pre-eclamptic umbilical cord plasma concentrations are decreased relative to normal pregnancy, possibly reflecting a decrease in placental production. At the same time maternal levels are increased relative to normal pregnancies and this possibly reflects an increase in myometrial/endovascular production. There is no doubt that the predominant actions of these hormones are local and whether plasma levels are a true reflection of dynamic changes in local production and effect is yet to be seen. This study represents a promising start in identifying large stable molecules which could be markers for pre-eclampsia. This study has relatively small numbers of patients and work still needs to be done to determine the utility of umbilical cord levels in early phases of the disease. Whether serum levels of N-terminal proCNP can provide an accurate reflection of normal or pathological maternal uterine adaptation to pregnancy remains a question worth evaluating.
Transition metal poly(1-pyrazolyl)borates containing other ligands (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTransition metal poly(1-pyrazolyl)borates containing other ligandsSwiatoslaw. TrofimenkoCite this: J. Am. Chem. Soc. 1967, 89, 15, 3904–3905Publication Date (Print):July 1, 1967Publication History Published online1 May 2002Published inissue 1 July 1967https://pubs.acs.org/doi/10.1021/ja00991a042https://doi.org/10.1021/ja00991a042research-articleACS PublicationsRequest reuse permissionsArticle Views503Altmetric-Citations39LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Architectural considerations for a microprogrammable emulating engine using bit-slices (1980)

This paper describes architectural considerations which led to the design of a fast programmable processor made from ECL bit-slioes. The processor will be used as an on-line data filtering engine for high energy physics experiments. Unlike prior designs of such engines, the processor supports both user (horizontal) microcode and emulation of the PDP-11 fixed point instruction set (without memory management and multiple interrupt levels). In addition to an overview of the techniques used to achieve an execution speed of roughly three times that of the PDP-11/70 CPU, strengths and weaknesses of bit- slices are discussed, as are the use of a Signetics meta assembler and the ISPS Architecture simulation system.
The effects of Lactobacillus buchneri with or without a homolactic bacterium on the fermentation and aerobic stability of corn silages made at different locations (2010)

Whole-plant corn (31 to 39% dry matter) from several locations was chopped, treated with nothing (U), Lactobacillus buchneri 40788 (4 x 10(5) cfu/g; LB), or L. buchneri (4 x 10(5) cfu/g) and Pediococcus pentosaceus (1 x 10(5) cfu/g; LBPP), and packed into quadruplicate 20-L silos to determine their effects on silage fermentation and aerobic stability after 120 d of storage. The experiment was a randomized complete block design with main effects of treatment (T), block (location; L), and T x L interaction. Dry matter recovery was different among locations but unaffected by T. The population of lactic acid bacteria was greater in LB and LBPP than in U, and the opposite was true regarding the population of yeasts. Numbers of L. buchneri (colony-forming unit equivalents), determined by a real-time quantitative polymerase chain reaction, were higher in 4 of 5 locations for LB and LBPP compared with U (T x L interaction) with an average 6.70 log cfu/g for LB and LBPP versus 4.87 log cfu/g for U. Silages inoculated with LB and LBPP had higher silage pH and higher concentrations of acetic acid and 1,2 propanediol but lower concentrations of ethanol and water-soluble carbohydrates; there was a T x L interaction for all these variables. Aerobic stability was improved by LB and LBPP (mean of 136 h) compared with U (44 h), but there was an interaction between T x L. In general, locations with the highest population of L. buchneri had the largest increases in acetic acid and, consequently, the greatest improvements in aerobic stability. The addition of L. buchneri 40788 alone or with P. pentosaceus resulted in similar effects on silage fermentation and aerobic stability, but the effects were variable among locations, suggesting that unidentified factors; for example, in the field or on the forage crop, may alter the effectiveness of microbial inoculation.
Practically Realizable Efficient Data Allocation and Replication Strategies for Distributed Databases with Buffer Constraints (2006)

In this paper, we address the performance of distributed database systems with buffer constraints. Specifically, our objective is to design and analyze efficient data allocation and replication strategies to minimize the total servicing cost for an arbitrary read/write request sequence, under finite buffer constraints of the nodes in the system. When the available buffer space in a node is not enough to store a copy of an object, the decision has to be made on whether or not we should evict one or more objects in use to give room for the new object copy. In this paper, we design and analyze the data replication strategies with the model of dynamic window mechanism (DWM) algorithm jointly implemented with different types of object replacement strategies (no replacement, LRU, and LFU) commonly found in practice. We consider situations wherein the object sizes are identical as well as heterogeneous. We will show the impact on the performance of the allocation and replication strategies due to the limited local database buffer capacities. We analyze and quantify theoretically (using competitive analysis) the performances of all the proposed algorithms. Further, we perform rigorous simulation experiments to validate the findings with respect to several influencing parameters. Several useful conclusions are drawn based on the experimental results and we highlight the usefulness of the algorithms under different situations
Presence of FoxP3+ Regulatory T Cells Predicts Outcome of Subclinical Rejection of Renal Allografts (2008)

Subclinical rejection (SCR) of renal allografts refers to histologic patterns of acute rejection despite stable renal function. The clinical approach to SCR is controversial; it would be helpful to identify biomarkers that could determine whether the identified cellular infiltrates were detrimental. For investigation of whether the presence of FoxP3+ regulatory T cells (Treg) could help determine the functional importance of tubulointerstitial infiltrates observed in 6-mo protocol biopsies, 37 cases of SCR were evaluated. The presence of FoxP3+ Treg discriminated harmless from injurious infiltrates, evidenced by independently predicting better graft function 2 and 3 yr after transplantation. Furthermore, the FoxP3+ Treg/CD3+ T cell ratio positively correlated with graft function at 2 yr after transplantation, suggesting that an increasing proportion of Treg within the global T cell infiltrate may facilitate renal engraftment; therefore, immunostaining for FoxP3+ Treg in patients with SCR on protocol biopsies may ultimately be useful to identify patients who may require alterations in their immunosuppressive regimens.
Novel IS <i>6110</i> Insertion Sites in the Direct Repeat Locus of <i>Mycobacterium tuberculosis</i> Clinical Strains from the St. Petersburg Area of Russia and Evolutionary and Epidemiological Considerations (2002)

A modification of spoligotyping with primers derived from the direct repeat (DR) and IS6110 sequences was used to identify IS6110 insertions in the DR locus of Mycobacterium tuberculosis clinical strains from the St. Petersburg area of Russia. Novel IS6110 insertions were identified: (i) in two epidemiologically unlinked Beijing family strains, an asymmetrical direct insertion in DR37; (ii) in a non-Beijing strain, an asymmetrical insertion in the opposite orientation in DR38; (iii) in another non-Beijing strain, a direct insertion in DR38 and one in the opposite orientation in DR14 (DR numbering is according to standard spoligotyping). Our results strengthen an observation that the DR locus structure is extremely conserved in the Beijing genotype. Asymmetrical insertions prevented detection of the adjacent spacer by standard spoligotyping. This, therefore, should be taken into consideration when similar spoligoprofiles that differ only in signals 37 and 38 are interpreted.
The kallikrein world: an update on the human tissue kallikreins (2006)

Human tissue kallikreins (hKs) are attracting increased attention owing to their association with various forms of cancer and other diseases. Human tissue kallikrein genes represent the largest contiguous group of proteases within the human genome. There are many areas of kallikrein research that need to be further explored, including their tissue expression patterns, their regulation, identification of specific substrates, their participation in proteolytic cascades, and their clinical applicability as cancer biomarkers and therapeutic targets. In this review, we briefly describe the current status of kallikrein research and identify future avenues that will enhance our understanding of their function and involvement in human diseases.
Dynamic integration and query processing with ranked role sets (2002)

The role-set approach is a new conceptual framework for data integration in multidatabase systems that maintains the materialization autonomy of local database systems and provides users with more accurate information. The role-set approach presents the answer to a query as a set of relations where the distinct intersections between the relations correspond to the various roles played by an entity. The authors show how the basic role-based approach can be extended in the absence of information about the multidatabase keys (global IDs). They propose a strategy based on ranked role-sets that makes use of a semantic integration procedure based on neural networks to determine candidate global IDs. The data integration and query processing steps then produce a number of role-sets, ranked by the similarity of the candidate IDs.
Noncovalently functionalized highly conducting carbon nanotube films with enhanced doping stability via an amide linkage (2013)

Creating superior electrical properties from macroscopic assembly of carbon nanotubes (CNTs) to replace metal is still an unaccomplished goal. Here we report a noncovalent functionalization method to connect individual CNTs with an electrical conductivity reaching 9150 S cm(-1) and the mechanical properties can be increased by an order of 1-2.