gebhart/patrepeval huggingface dataset:
Stability of naturally occurring pyrazines and construction route of pyrazine rings (1991)

Abstract Naturally occurring pyrazines fit well the theory that conformity to the TCS rule gives a stable molecular system. Thus, many pyrazines so far synthesized and those in nature which are energetically very stable molecules can be synthetically quite accessible. The TCS rule applies very well to the construction route of pyrazine rings.
SpyTag/SpyCatcher Functionalization of E2 Nanocages with Stimuli-Responsive Z-ELP Affinity Domains for Tunable Monoclonal Antibody Binding and Precipitation Properties (2018)

E2 nanocages functionalized with Z-domain-elastin-like polypeptide affinity ligands (Z-ELP<sub>40</sub>) using Sortase A (SrtA) ligation have been shown to be a promising scaffold for purifying monoclonal antibodies (mAbs) based on affinity precipitation. However, the reversible nature of SrtA reaction has been attributed to the low ligation efficiency (<25%) and has significantly limited the practical utility of the technology. Here, we reported an improved conjugation platform using the SpyTag/SpyCatcher pair to form a spontaneous isopeptide bond between SpyTag-E2 and Z-ELP-SpyCatcher fusion proteins of two different ELP chain-lengths. Using this system, E2 ligation efficiencies exceeding 90% were obtained with both 40- and 80-repeat Z-ELP-SpyCatcher fusions. This enabled the production of nanocages fully functionalized with Z-ELP for improved aggregation and mAb binding. Compared to the 50% decorated Z-ELP<sub>40</sub>-E2 nanocages produced by SrtA ligation, the fully decorated Z-ELP<sub>80</sub>-Spy-E2 nanocages exhibited a 10 °C lower transition temperature and a 2-fold higher mAb binding capacity. The improved transition property of the longer Z-ELP<sub>80</sub> backbone allowed for >90% recovery of Z-ELP<sub>80</sub>-Spy-E2 nanocages at room temperature using 0.1 M ammonium sulfate after mAb elution. The flexibility of customizing different affinity domains onto the SpyTag-E2 scaffold should expand our ability to purify other non-mAb target proteins based on affinity precipitation.
Modulo-2piphase sequence estimation (Corresp.) (1980)

The probabilistic evolution of random walk on the circle is studied, and the results are used to derive a maximum {\em a posteriori} probability (MAP) sequence estimator for phase. The sequence estimator is a Viterbi tracker for tracking phase on a finite-dimensional grid in <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">[-\pi,\pi)</tex> . The algorithm is shown to provide a convenient method for obtaining fixed-lag phase estimates. Performance characteristics are presented and compared with several published nonlinear filtering algorithms.
[A protocol for monitoring antimalarial treatment]. (1990)

We are showing a protocol to survey the treatment by APS, with a computer equipment that enable us to examine very shortly the central field of vision and the ERG; but that least investigation can be EOG or a PEV, according to the toxic pathology we are studying.
Forecasting network performance to support dynamic scheduling using the network weather service (2002)

The Network Weather Service is a generalizable and extensible facility designed to provide dynamic resource performance forecasts in metacomputing environments. In this paper, we outline its design and detail the predictive performance of the forecasts it generates. While the forecasting methods are general, we focus on their ability to predict the TCP/IP end-to-end throughput and latency that is attainable by an application using systems located at different sites. Such network forecasts are needed both to support scheduling, and by the metacomputing software infrastructure to develop quality-of-service guarantees.
Neurology (2019)

The profession of neurology has come a long way over the years. In 1664, Thomas Willis in his textbook Cerebral Anatomy described the different structures in the brain and coined the word “neurology”—a branch of medicine concerned with the structure, function, and diseases of the nervous system. Although our profession may have originated about 355 years ago, it has had more rapid advancement in the last 50 years.
LTE-A interworking for seamless service provisioning (2014)

Following the Always Best Connection (ABC) principle of the 4th generation wireless networks users of mobile services would be provided with connectivity to the best access technology all the time. In such a context mobile devices are equipped with multiple radio interfaces allowing connectivity to the most suitable network environment based on users requirements and operators policies. Seamless vertical handover plays the key role for mobility across various access networks offering service continuity to users. In this paper seamless handover solutions are presented between 3GPP (Third Generation Partnership Project) and non-3GPP wireless access technologies utilizing functionalities of the Evolved Packet Core (EPC) network of the LTE-A, as well as, of the IEEE 802.21 standard. The schemes presented provide low latencies while supporting services QoS constraints, as well as, user requirements and provider policies.
Thermostable Organo‐phosphor: Low‐Vibrational Coordination Polymers That Exhibit Different Intermolecular Interactions (2012)

Novel thermostable organo-phosphor compounds composed of coordination polymers are reported. Tight-binding structures with intermolecular interactions of the coordination polymer induce both thermostability (decomposition point >300 °C) and high emission quantum yield (ΦLn=83 %). Their structures (see picture), thermogravimetric analyses, and remarkable photophysical properties are presented for the first time.
Self-assembling Peptides: From Bio-inspired Materials to Bone Regeneration (2008)

In recent years, the development of new biomaterials with specifications for tissue and organ functional requirements-such as proper biological, structural, and biomechanical properties as well as designed control for biodegradation and therapeutic drug-release capacity-is the main aim of many academic and industrial programs. Hence, the concept of molecular self-assembly is the driving force for the development of new biomaterials that support the growth and functional differentiation of cells and tissues in a controlled manner. The discovery, properties, and development of self-assembling peptides to be used as three-dimensional (3D) scaffolds based on their similarity (in structure and mechanical features) to extracellular matrices are described. Self-assembling peptides can be used for in vitro applications for cell 3D culture as well as in vivo for tissue regeneration such as bone and optical nerve repair, as well as for drug delivery of mediators to improve therapy, as in the case of myocardial infarction. Finally, the use of self-assembling materials in combination with a bioengineering platform is proposed to assist functional bone regeneration in cases of larger bone defects, including exposed fractures due to trauma and spinal disorders dealing with high loadings, as well as replacement of big bone structures due to tumors.
Graphene-based in-plane micro-supercapacitors with high power and energy densities (2013)

Micro-supercapacitors are important on-chip micro-power sources for miniaturized electronic devices. Although the performance of micro-supercapacitors has been significantly advanced by fabricating nanostructured materials, developing thin-film manufacture technologies and device architectures, their power or energy densities remain far from those of electrolytic capacitors or lithium thin-film batteries. Here we demonstrate graphene-based in-plane interdigital micro-supercapacitors on arbitrary substrates. The resulting micro-supercapacitors deliver an area capacitance of 80.7 μF cm⁻² and a stack capacitance of 17.9 F cm⁻³. Further, they show a power density of 495 W cm⁻³ that is higher than electrolytic capacitors, and an energy density of 2.5 mWh cm⁻³ that is comparable to lithium thin-film batteries, in association with superior cycling stability. Such microdevices allow for operations at ultrahigh rate up to 1,000 V s⁻¹, three orders of magnitude higher than that of conventional supercapacitors. Micro-supercapacitors with an in-plane geometry have great promise for numerous miniaturized or flexible electronic applications.
Snubberless switching-off characteristics of IGCTs equipped in high power three-level neutral point clamped converters (2005)

Along with the improved design and broad applications of multi-level topologies, as a new commercial power switch device in recent years, IGCT has led the rapid development of high power converters in many applications, such as medium voltage adjustable speed drive and FACTs. Since the power electronic device is the base of these converters, the switching-off characteristics of IGCTs have become one of the key points in converters' design and analysis, especially when snubber circuits are absent. This paper focuses on the snubberless switching-off characteristics of IGCTs equipped in the high power three-level neutral point clamped (NPC) converter. According to the physical characteristics of switch devices and commutating mechanism between different switching processes in the converter, the switching-off characteristics of IGCTs in different topology positions under different switching conditions are described, simulated and tested. The results of simulation and experiments are compared, especially the voltage spikes by IGCTs' switching off. The relation between the switching-off characteristics and the other elements of the converter is also discussed in detail, such as topology position, PWM strategy and mechanical structure. Finally, some helpful conclusions for high power converters' design and analysis are drawn
Monitoring breath markers under controlled conditions (2015)

Breath analysis has the potential to detect and monitor diseases as well as to reduce the corresponding medical costs while improving the quality of a patient's life. Herein, a portable prototype, consisting of a commercial breath sampler modified to work as a platform for solid-state gas sensors was developed. The sensor is placed close to the mouth (<10 cm) and minimizes the mouth-to-sensor path to avoid contamination and dilution of the target breath marker. Additionally with an appropriate cooling concept, even high sensor operating temperatures (e.g. 350 °C) could be used. Controlled sampling is crucial for accurate repeatable analysis of the human breath and these concerns have been addressed by this novel prototype. The device helps a subject control their exhaled flow rate which increases reproducibility of intra-subject breath samples. The operation of this flame-made selective chemo-resistive gas sensor is demonstrated by the detection of breath acetone.
Quantum Photonic Network: Concept, Basic Tools, and Future Issues (2014)

We present practical GHz-clocked QKD systems, next generation entanglement QKD technologies, and QKD platform to manage the secure keys and to support a variety of applications. We then show the intrinsic limit of QKD, i.e., a key rate bound, and discuss how to realize the provable (information theoretic) security with a larger secrecy capacity over longer distances. In particular, we present a basic theory of physical layer cryptography, which characterizes the secrecy capacity, and engineers the tradeoff between the efficiency of reliable transmission and secrecy of communication. We introduce a concept to unify these schemes in photonic network, referred to as quantum photonic network. Future issues for realizing this new network paradigm are discussed.
Cp<sub>2</sub>TiCl-Catalyzed Epoxide Radical Ring Opening:  A New Initiating Methodology for Graft Copolymer Synthesis (2006)

The first example of the use of epoxides in radical grafting copolymerizations was exemplified by the grafting of poly(methyl methacrylate) (PMMA), poly(butyl methacrylate) (PBMA), poly(butyl acrylate) (PBA), and poly(styrene) (PSt) from poly(glycidyl methacrylate) (PGMA) and from copolymers of GMA with MMA and St as well as by the iterative synthesis of mixed arm graft copolymers such as (PGMA-g-PMMA)-g-PSt and ((PGMA-g-PMMA)-g-PSt)-g-PBMA with a wide range of molecular weights and compositions. The grafting was demonstrated by a combination of gel permeation chromatography (GPC), NMR, and differential scanning calorimetry (DSC) investigations. The polymerization is initiated by the Cp2TiCl-catalyzed radical ring opening of the epoxide group of GMA and is optionally controlled by CuBr2/bipyridyl. This methodology does not require any epoxide protection/deprotection steps and provides the typical advantages of radical polymerizations and convenient access to complex macromolecular architectures.
Active feedback-controlled dielectrophoretic levitation (1986)

Dielectrophoretic levitation of small metallic particles in insulating dielectric liquids is achieved using a microprocessor-controlled digital feedback system. An optical detector senses vertical particle position and the error signal generated controls the voltage applied to the electrodes of the levitator cell. Experiments with single particles confirm a theoretical expression for the axial profile of the electric field. The method of images is used to calculate the effective dipole moments for chains of conducting particles. Experimental levitation data obtained using two- and three-particle chains provide preliminary confirmation for these effective dipole moment expressions.
Macromol. Rapid Commun. 11/2008 (2008)

Back Cover: Donor‐acceptor rod‐coil block copolymers have been synthesized by Grignard metathesis polymerization of regioregular P3HT macroinitiators and nitroxide‐mediated radical polymerization of flexible blocks followed by C60 grafting reactions. These copolymers are expected to improve the solar cells active layer morphology and as a consequence the energy conversion efficiency. Further details can be found in the article by F. Richard, C. Brochon, * N. Leclerc, D. Eckhardt, T. Heiser, and G. Hadziioannouon page 885.
Secondary Lymphoid-Tissue Chemokine (SLC) Is Chemotactic for Mature Dendritic Cells (1999)

Dendritic cells (DC) take up antigen from the periphery and migrate to the lymphoid organs where they present the processed antigens to T cells. The propensity of DC to migrate changes during DC maturation and is probably dependent on alterations in the expression of chemokine receptors on the surface of DC. Secondary lymphoid tissue chemokine (SLC), a recently discovered chemokine for naı̈ve T cells, is primarily expressed in secondary lymphoid organs and may be important for colocalizing T cells with other cell types important for T-cell activation. We show here that SLC is a potent chemokine for mature DC but does not act on immature DC. SLC also induced calcium mobilization specifically in mature DC. SLC and Epstein-Barr virus–induced molecule 1 ligand chemokine completely cross-desensitized the calcium response of each other, indicating that they share similar signaling pathways in DC. The finding that SLC is a potent chemokine for DC as well as naı̈ve T cells suggests that it plays a role in colocalizing these two cell types leading to cognate T-cell activation.
Insulin-like growth factor-I (IGF-I) and retinoic acid modulation of IGF-binding proteins (IGFBPs): IGFBP-2, -3, and -4 gene expression and protein secretion in a breast cancer cell line (1992)

Retinoic acid (RA) blocks insulin-like growth factor-I (IGF-I) stimulation of proliferation in the MCF-7 breast carcinoma cell line, and this is associated with the appearance of 42- to 46-kilodalton (kDa) IGF-binding proteins(s) (IGFBPs) in the conditioned medium (CM), in addition to the approximately 34- and 27-kDa IGFBPs present in the CM of unstimulated cells. Using immunological, biochemical, and molecular biological criteria, we have identified the 27-kDa band as IGFBP-4, the 34-kDa band as IGFBP-2, and the 42- to 46-kDa band as IGFBP-3. IGF-I alone stimulated MCF-7 cell proliferation, and this was associated with a large increase in IGFBP-2 in the CM. RA alone resulted in increased IGFBP-4 levels and the appearance of IGFBP-3 in the CM. The combination of RA and IGF-I, which resulted in decreased cellular proliferation, was associated with the appearance of IGFBP-3 in the CM at levels far exceeding those seen with RA alone. The effect of IGF-I on IGFBP-2 levels and the synergistic action of IGF-I and RA on IGFBP-3 levels in CM were blocked by alpha IR3, a monoclonal antibody to the human IGF-I receptor, indicating that these effects required signal transduction through the IGF-I receptor. IGFBP-2, -3, and -4 mRNAs were detected in unstimulated MCF-7 cells. RA increased IGFBP-3 mRNA levels, suggesting that transcriptional events contribute to the RA stimulation of IGFBP-3 appearance in CM. In contrast, the increase in IGFBP-2 protein in CM after IGF-I treatment appeared to be greater than the increase in IGFBP-2 mRNA levels. The increase in IGFBP-3 protein in CM in response to the combination of RA and IGF-I was much greater than the increase in IGFBP-3 mRNA. These results suggest that the action of RA and IGF-I in combination to increase IGFBP-3 protein in CM is principally translational or posttranslational. We speculate that RA inhibition of IGF-I-stimulated MCF-7 cell proliferation may be due to IGFBP-3, or that increased levels of IGFBP-3 in response to growth inhibition represent a compensatory response.
Effect of Vincristine, Adriamycin and Glucocorticoids on Myeloma Cells in vitro (1993)

The effect of in vitro exposure to vincristine, Adriamycin, and glucocorticoids was studied in 4 human myeloma cell lines. The drug concentrations tested approximated the steady-state plasma level achievable clinically. Marked growth inhibition was seen in all 4 cell lines with vincristine, but in only 2 with Adriamycin. Glucocorticoids were only minimally inhibitory. The inhibition by glucocorticoids was reversible after drug removal, but that by vincristine and Adriamycin was sustained except the vincristine inhibition of ARH-77 cells. The degree of cell growth inhibition paralleled the reduction in tumor cell 3H-thymidine uptake. Cell cycle distribution analysis showed an arrest of myeloma cells at M/G2 phase by vincristine and Adriamycin and an inhibition of myeloma cells from entering into S phase by dexamethasone. Dose-response analysis with ARH-77 cells, a cell line that appeared the most chemoresistant, showed that the growth-inhibitory effect of Adriamycin and vincristine was roughly proportional to the product of drug concentration and exposure time. However, in contrast to Adriamycin, an effective vincristine concentration and exposure time that totally inhibited cell growth was unable to prevent cell regrowth after drug removal. A higher vincristine concentration appeared to be more effective in preventing cell regrowth.
Early Visual Cortex as a Multiscale Cognitive Blackboard (2016)

Neurons in early visual cortical areas not only represent incoming visual information but are also engaged by higher level cognitive processes, including attention, working memory, imagery, and decision-making. Are these cognitive effects an epiphenomenon or are they functionally relevant for these mental operations? We review evidence supporting the hypothesis that the modulation of activity in early visual areas has a causal role in cognition. The modulatory influences allow the early visual cortex to act as a multiscale cognitive blackboard for read and write operations by higher visual areas, which can thereby efficiently exchange information. This blackboard architecture explains how the activity of neurons in the early visual cortex contributes to scene segmentation and working memory, and relates to the subject's inferences about the visual world. The architecture also has distinct advantages for the processing of visual routines that rely on a number of sequentially executed processing steps.
Experimental studies on fading reduction by four‐direction antenna pattern diversity reception with variable multithreshold switching strategy (1990)

Abstract An antenna pattern diversity reception system was constructed experimentally as a means to cope with multipath fading in mobile communication, where the four‐direction antenna is used as the diversity branches, which themselves have the fading reduction effect. The variable threshold switching method is employed as the output scheme from the diversity branches. The switching algorithm for the four‐branch multithreshold reception is discussed. From the computer simulation based on the actually measured fading data, the optimal values for the parameters of the branch switching control algorithm are determined. A field experiment is made using the experimental system, and it is verified that the short‐term fading is improved in the actual multipath environment with the value close to the theoretical value, for the selection switching by four receivers using uncorrelated branches with Rayleigh distribution.
INTERNATIONAL JOURNAL OF PHARMACY & LIFE SCIENCES Microsphere as a novel drug delivery (2011)

Microspheres are spherical & free flowing particles ranging in average particle size from 1 to 50 micr ons which consist of proteins or synthetic polymers. Some of the problems of overcome by producing control drug delivery system which enhances the therapeutic efficacy of a given drug. One such approach is using microsphere s as carriers for drugs. The target site drug deliver with Specif icity & maintain the the concentration at site of i nterest without untoward effects. It will find the central place in novel drug delivery. Drugs can be targeted to spec ific sites in the body using microspheres. Degree of targeting can be achieved by localization of the drug to a specific area in body (for example in lungs), to a particular group of ce lls (for example, kupffer cells) and even to the in tracellular structures (as lyzosomes or cell nucleus). The rate of drug release from the microspheres dictates the ir therapeutic action. Release is governed by the molecular struct ure of the drug and the polymer, the resistance of the polymer to degradation, and the surface area along with the po rosity of the microspheres. The internal structure of the microspheres can vary as a function of the microenc apsulation process employed. Controlled drug releas e from microspheres occurs by diffusion of the drug throug h a polymeric excipient, diffusion of the entrapped drug through the pores in the polymeric microspheres.
Novel anamorphic mite-associated fungi belonging to the Ustilaginomycetes: Meira geulakonigii gen. nov., sp. nov., Meira argovae sp. nov. and Acaromyces ingoldii gen. nov., sp. nov. (2003)

Three novel mite-associated basidiomycetous species are described in two new anamorph genera as Meira geulakonigii gen. nov., sp. nov. (type CBS 110052(T)=NRRL Y-27483(T)=AS 004(T)), Meira argovae sp. nov. (type CBS 110053(T)=NRRL Y-27482(T)=AS 005(T)) and Acaromyces ingoldii gen. nov., sp. nov. (type CBS 110050(T)=NRRL Y-27484(T)=AS 001(T)). Morphologically, these fungi are similar to the yeast-like fungi classified in the Ustilaginales, such as Pseudozyma species. However, analysis of the D1/D2 domain of the LSU rDNA suggests that they belong to two different lineages within the Exobasidiomycetidae of the Ustilaginomycetes (Basidiomycota). Furthermore, these fungi may be of interest for the biocontrol of mites, as they reduced mite numbers by approximately 80 % after inoculation.