gebhart/patrepeval huggingface dataset:
Functional interrelationship between the WASF3 and KISS1 metastasis‐associated genes in breast cancer cells (2011)

Loss of WASF3 function in breast cancer cells results in loss of invasion phenotypes and reduced metastatic potential. By using oligonucleotide arrays, we now demonstrate that knockdown of WASF3 leads to the upregulation of the KISS1 metastasis suppressor gene with concomitant reduced invasion and loss of matrix metalloproteinases (MMP)-9 activity. Using a luciferase reporter, KISS1 transcription is significantly increased in the absence of WASF3. Knockdown of KISS1 in WASF3-silenced cells resulted in the recovery of the invasion phenotype. WASF3 knockdown also resulted in elevated IκBα levels in the cytoplasm and reduced levels of nuclear factor-kappa-B (NF-κB) p65/50 subunits in the nucleus. Tumor necrosis factor-alpha (TNF-α) has been associated with cell invasion through induction of MMP-9 production via KISS1 regulation of the NF-κB pathway. When WASF3 knockdown cells are treated with TNF-α, no effect is seen on invasion or nuclear translocation of NF-κB. Thus, coordinated expression patterns of the WASF3 metastasis promoter gene and the KISS1 metastasis suppressor gene appear to exert their influence through inhibition of NF-κB signaling, which in turn regulates MMP-9 production facilitating invasion.
Variable geometry manned orbital vehicle Patent (1970)

Variable geometry manned orbital vehicle having high aerodynamic efficiency over wide speed range and incorporating auxiliary pivotal wings
Nanostructured platinum grass enables superior impedance reduction for neural microelectrodes (2015)

Micro-sized electrodes are essential for highly sensitive communication at the neural interface with superior spatial resolution. However, such small electrodes inevitably suffer from high electrical impedance and thus high levels of thermal noise deteriorating the signal to noise ratio. In order to overcome this problem, a nanostructured Pt-coating was introduced as add-on functionalization for impedance reduction of small electrodes. In comparison to platinum black deposition, all used chemicals in the deposition process are free from cytotoxic components. The grass-like nanostructure was found to reduce the impedance by almost two orders of magnitude compared to untreated samples which was lower than what could be achieved with conventional electrode coatings like IrOx or PEDOT. The realization of the Pt-grass coating is performed via a simple electrochemical process which can be applied to virtually any possible electrode type and accordingly shows potential as a universal impedance reduction strategy. Elution tests revealed non-toxicity of the Pt-grass and the coating was found to exhibit strong adhesion to the metallized substrate.
A RBF neural network model for anti-money laundering (2008)

Money laundering (ML) is a serious crime which makes it necessary to develop detection methods in transactions. Some researches have been carried on, but the problem is not thoroughly solved. Aiming at the low detection rate of suspicious transaction at home and abroad in financial field, and with an analysis of radial basis function (RBF) neural network, we propose a radial basis function neural network model based on APC-III clustering algorithm and recursive least square algorithm for anti-money laundering (AML). APC-III clustering algorithm is used for determining the parameters of radial basis function in hidden layer, and recursive least square (RLS) algorithm is adopted to update weights of connections between hidden layer and output layer. The proposed method is compared against support vector machine (SVM) and outlier detection methods, which show that the proposed method has the highest detection rate and the lowest false positive rate. Thus our method is proved to have both theoretical and practical value for anti-money laundering.
Occurrence of D-rhamnan as the common antigen reactive against monoclonal antibody E87 in Pseudomonas aeruginosa IFO 3080 and other strains (1990)

S. Sawada and co-workers reported that a monoclonal antibody (MAb), E87, interacted with about 80% of Pseudomonas aeruginosa isolates, and they separated a rhamnose-rich polysaccharide as the probable antigen for MAb E87 from P. aeruginosa IFO 3080 (S. Sawada, T. Kawamura, Y. Masuho, and K. Tomibe, J. Infec. Dis. 152:1290-1299, 1985). In the present study, the rhamnose-rich polysaccharide was shown to be structurally and immunologically identical to the D-rhamnan of P. aeruginosa IID 1008 (S. Yokota, S. Kaya, S. Sawada, T. Kawamura, Y. Araki, and E. Ito, Eur. J. Biochem. 167:203-209, 1987). Furthermore, a set of enzymes responsible for the formation of GDP-rhamnose (probably in a D-form) from GDP-D-mannose was found in the 100,000 x g supernatant fractions obtained from all of nine P. aeruginosa strains reactive against MAb E87. The result strongly supports a possibility that lipopolysaccharides having a D-rhamnan chain widely occur as the common antigen among various P. aeruginosa isolates.
A Cordon Sanitaire at the India-Bangladesh border (2020)

This commentary considers the effects of COVID-19 on the borderland communities of Meghalaya, a hill state in Northeast India. Efforts to fence this border have failed to deter informal exchanges with Bangladeshi neighbours, but the national COVID-19 lockdown looks set to shift locals into relations of dependency on and within the nation’s borders, rather than across them.
Federal Energy Management: Year in Review 2003 (2004)

This is a document which illustrates how FEMP's four service areas are helping agencies target key opportunities.
Crystallization and preliminary X-ray studies of mouse tumor necrosis factor (1997)

Well diffracting crystals of recombinant mouse tumor necrosis factor (mTNF) have been obtained. The sitting-drop vapor-diffusion method was used to grow crystals suitable for X-ray studies from solutions containing methoxypolyethylene glycol 2000 and isopropanol as precipitants. The crystals belong to the space group P1 with unit-cell dimensions a = 49.40, b = 48.24, c = 51.13 A, alpha = 115.06, beta = 103.32, gamma = 91.27 degrees and one trimer in the asymmetric unit. Crystals are stable to X-rays and diffract beyond 2.0 A. Cooling the crystal during data collection is necessary since crystals dissolve at room temperature.
The Suitability of Quality-of-Life Questionnaires for Psoriasis Research (2002)

None of the identified psoriasis-specific questionnaires met the inclusion criteria. Data on the suitability of the included questionnaires for psoriasis research were relatively sparse. The included generic questionnaires allow comparisons with nondermatologic diseases but do not allow assessment of relevant dermatology-specific aspects and are not sensitive to subtle effects of psoriasis on QOL. On the basis of the psychometric data of the present review, we find the Skindex-29 to be the most valuable dermatology-specific questionnaire for psoriasis research. Combination of the Skindex-29 with the generic SF-36 combines the merits of both types of questionnaires and we therefore recommend this combination.
Macrocycles and their selectivity for metal ions on the basis of size (1986)

Abstract
Extraction of Tritium Present in Helium-3 (1960)

The concentration of tritium present in 10 liters of He3 has been reduced to the order of 10−11 by absorption of the tritium in pyrophoric uranium. This purity was required in order that the resolution of a gridded ionization chamber neutron spectrometer containing the He3 should not be adversely affected by the tritium. Details of the purification system and method are given. The assay of the tritium by introduction of samples of the He3 into Geiger counters is discussed.
Suspended patch antennas with electromagnetically coupled inverted microstrip feed for circular polarization (2002)

The paper demonstrates a suspended nearly square patch antenna with offset feed and a square patch antenna with truncated corners for circular polarization. The antennas are excited by an electromagnetically coupled inverted microstrip feed. In addition a new transition between conventional microstrip and inverted microstrip is proposed. The measured results include the axial ratio and the impedance bandwidth of the antennas.
Parallel training of convolutional neural networks for small sample learning (2015)

We propose a parallel training framework of convolutional neural networks (CNNs) for small sample learning. In the framework we model the feature filter process and show Sadowsky energy distribution exists in the model. Using Sadowsky energy distribution, the weights in convolutional kernels can be rearranged after each update according to special cases. With this rearrangement, each CNNs in the framework has different predicted probability especially for easily misclassified samples, which avoids the situation of a low predicted probability traditional CNNs may have. The class that gets the maximum predicted probability among the CNNs would be chosen as the result of prediction. Our CNNs framework gives better hand-written digit classification for small samples than one-stage CNNs, and has a faster convergence rate than multiplestages CNNs.
Effect of cytochalasin B on the maturation of enveloped viruses. (1979)

The maturation of two enveloped viruses, influenza and vesicular stomatitis, occurs in cells treated with cytochalasin B. Virions produced in the presence of 50 microgram/ml cytochalasin B (CB) appear to be as infectious as those from control cells, indicating that polymerized actin is not required for the assembly of functional viral components. CB inhibits the release of influenza virus from treated cells, a phenomenon which appears to be a result of the synthesis of an aberrant neuraminidase (NA) glycoprotein; virions grown in CB-treated cells had a 90% reduction in specific enzymatic activity. We found that both influenza viral glycoproteins (NA and Hemagglutinin glycoprotein) had faster electrophoretic mobilities and were more heterogeneous in CB-treated cells as compared with controls. We also observed complete inhibition of incorporation of labeled glucosamine into viral glycoproteins in the presence of the drug. It was of interest that CB-induced inhibition of glycosylation appeared to cause loss of neuraminidase function, whereas hemagglutinating activity was not noticeably impaired. The presence of altered glycoproteins did not significantly diminish the infectivity of either influenza virus or vesicular stomatitis virus. Our results indicate that no step in the maturation of enveloped viruses is dependent upon an intact cytoskeletal network.
Learning to classify documents according to genre (2006)

Abstract Current document‐retrieval tools succeed in locating large numbers of documents relevant to a given query. While search results may be relevant according to the topic of the documents, it is more difficult to identify which of the relevant documents are most suitable for a particular user. Automatic genre analysis (i.e., the ability to distinguish documents according to style) would be a useful tool for identifying documents that are most suitable for a particular user. We investigate the use of machine learning for automatic genre classification. We introduce the idea of domain transfer—genre classifiers should be reusable across multiple topics—which does not arise in standard text classification. We investigate different features for building genre classifiers and their ability to transfer across multiple‐topic domains. We also show how different feature‐sets can be used in conjunction with each other to improve performance and reduce the number of documents that need to be labeled.
Type II strained layer superlattice: a potential infrared sensor material for space (2008)

The Missile Defense Agency's Advanced Technology Office is developing advanced passive electro-optical and infrared sensors for future space-based seekers by exploring new infrared detector materials. A Type II strained layer superlattice, one of the materials under development, has shown great potential for space applications. Theoretical results indicate that strained layer superlattice has the promise to be superior to current infrared sensor materials, such as HgCdTe, quantum well infrared photodetectors, and Si:As. Strained layer superlattice-based infrared detector materials combine the advantages of HgCdTe and quantum well infrared photodetectors. The bandgap of strained layer superlattice can be tuned for strong broadband absorption throughout the short-, mid-, long-, and very long wavelength infrared bands. The electronic band structure can be engineered to suppress Auger recombination noise and reduce the tunneling current. The device structures can be easily stacked for multicolor focal plane arrays. The III-V semiconductor fabrication offers the potential of producing low-defect-density, large-format focal plane arrays with high uniformity and high operability. A current program goal is to extend wavelengths to longer than 14 μm for space applications. This paper discusses the advantages of strained layer superlattice materials and describes efforts to improve the material quality, device design, and device processing.
Numerical simulation of resistive interconnects for integrated circuits (1985)

When interconnects for integrated circuits have been modeled, it has been normal to consider them only as straight tracks. In any practical circuit this is not the case and a more rigorous analysis is performed by the authors. The effects of corners and T-junctions are analyzed using finite elements and some models are presented which can be used by circuit designers to simulate circuit performance.
Joint blind rate detection and data decoding scheme for CDMA mobile stations in frequency selective Rayleigh fading channels (2002)

In this paper, we have derived a novel joint rate detection and data decoding scheme for variable-rate data transmission in DS-CDMA communication systems. It is shown that this joint scheme is optimal in the sense of minimizing frame error rate. The results of a software simulation of the proposed joint scheme in a three-path Rayleigh fading channel are presented. Performance comparison between the proposed scheme and two existing rate detection schemes is also provided.
A Distributed-Ledger Consortium Model for Collaborative Innovation (2017)

R3 has built a global consortium to focus on the application of distributed-ledger technology (DLT), which can help banks combat low return on equity and alleviate pressure on their operating costs. The authors explain the conditions that led to interest in DLT and introduce Corda, R3's shared ledger for recording and managing financial agreements.
Evaluation of five immunoassays for detection of Chlamydia psittaci in cloacal and conjunctival specimens from turkeys (1994)

Five commercially available immunoassays were evaluated for the detection of Chlamydia psittaci in cloacal and conjunctival swabs from industrially raised turkeys: IMAGEN (DAKO Diagnostics, Ely, Cambridgeshire, United Kingdom), Chlamydia CEL-VET IF (Cellabs, Brookvale, Australia), IDEIA (DAKO Diagnostics), CELISA (Cellabs), and CLEARVIEW (Unipath, Bedford, United Kingdom). Results were compared with isolation in Buffalo Green Monkey cells as a reference method. For the conjunctival samples, the sensitivities of the IMAGEN test, the Chlamydia CEL-VET IF test, the IDEIA, the CELISA, and the CLEARVIEW test were found to be 100, 66, 0, 0, and 0%, respectively, as compared to the reference test. Also for the conjunctival samples, the specificities of the IMAGEN test, the Chlamydia CEL-VET IF test, and the IDEIA were found to be 100, 11, and 92.8%, respectively. For the cloacal specimens, the sensitivities of the IMAGEN test, the Chlamydia CEL-VET IF test, the IDEIA, the CELISA, and the CLEARVIEW test were found to be 100, 93.3, 26.6, 0, and 53.3%, respectively. Also for the cloacal specimens, the specificities of the IMAGEN test, the Chlamydia CEL-VET IF test, the IDEIA, and the CLEARVIEW test were found to be 92, 12, 100, and 88%, respectively. The IMAGEN test was the most sensitive and specific direct chlamydia antigen detection test for cloacal and conjunctival samples from turkeys.
A New Liver Perfusion and Preservation System for Transplantation Research in Large Animals (1990)

A kidney perfusion machine, model MOX-100 (Waters Instruments, Ltd, Rochester, MN) was modified to allow continuous perfusion of the portal vein and pulsatile perfusion of the hepatic artery of the liver. Additional apparatus consists of a cooling system, a membrane oxygenator, a filter for foreign bodies, and bubble traps. This system not only allows hypothermic perfusion preservation of the liver graft, but furthermore enables investigation of ex vivo simulation of various circulatory circumstances in which physiological perfusion of the liver is studied. We have used this system to evaluate the viability of liver allografts preserved by cold storage. The liver was placed on the perfusion system and perfused with blood with a hematocrit of approximately 20%, and maintained at 37 degrees C for 3 h. The flows of the hepatic artery and portal vein were adjusted to 0.33 mL and 0.67 mL/g of liver tissue, respectively. Parameters of viability consisted of hourly bile output, oxygen consumption, liver enzymes, electrolytes, vascular resistance, and liver histology. This method of liver assessment in large animals will allow the objective evaluation of organ viability for transplantation and thereby improve the outcome of organ transplantation. Furthermore, this pump enables investigation into the pathophysiology of liver ischemia and preservation.
Determination of trace level ions by ion chromatography with concentrator columns (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of trace level ions by ion chromatography with concentrator columnsR. A. Wetzel, C. L. Anderson, Helmut. Schleicher, and G. D. CrookCite this: Anal. Chem. 1979, 51, 9, 1532–1535Publication Date (Print):August 1, 1979Publication History Published online1 May 2002Published inissue 1 August 1979https://pubs.acs.org/doi/10.1021/ac50045a040https://doi.org/10.1021/ac50045a040research-articleACS PublicationsRequest reuse permissionsArticle Views115Altmetric-Citations52LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Comparison of Three Wind Turbine Controller Synthesis Methodologies (2006)

The purpose of this work is to compare three wind turbine controller synthesis methodologies for the whole operating range of the plant. Wind turbine controllers are designed in order to optimize a trade-off between two main control objectives which are maximization of energy efficiency and alleviation of drive train dynamic loads. The considered control synthesis approach are the linear quadratic Gaussian control approach, the discrete pole placement with sensitivity function shaping method and the inversion of causal ordering graph. Simulations show good performances and robustness of the different controllers.
n-Pentenyl glycosides facilitate a stereoselective synthesis of the pentasaccharide core of the protein membrane anchor found in Trypanosoma brucei (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTn-Pentenyl glycosides facilitate a stereoselective synthesis of the pentasaccharide core of the protein membrane anchor found in Trypanosoma bruceiDavid R. Mootoo, Peter Konradsson, and Bert Fraser-ReidCite this: J. Am. Chem. Soc. 1989, 111, 22, 8540–8542Publication Date (Print):October 1, 1989Publication History Published online1 May 2002Published inissue 1 October 1989https://pubs.acs.org/doi/10.1021/ja00204a049https://doi.org/10.1021/ja00204a049research-articleACS PublicationsRequest reuse permissionsArticle Views516Altmetric-Citations95LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Relaxation effects in MRI‐based quantification of fat content and fatty acid composition (2013)

T(1) weighting has only a minor effect on FAC quantification in both fat/water mixtures and pure oils. T(2) weighting is mainly a concern in fat/water mixtures but may be corrected using a simplified model.
Diverse ensembles for active learning (2004)

Query by Committee is an effective approach to selective sampling in which disagreement amongst an ensemble of hypotheses is used to select data for labeling. Query by Bagging and Query by Boosting are two practical implementations of this approach that use Bagging and Boosting, respectively, to build the committees. For effective active learning, it is critical that the committee be made up of consistent hypotheses that are very different from each other. DECORATE is a recently developed method that directly constructs such diverse committees using artificial training data. This paper introduces ACTIVE-DECORATE, which uses DECORATE committees to select good training examples. Extensive experimental results demonstrate that, in general, ACTIVE-DECORATE outperforms both Query by Bagging and Query by Boosting.
MIXTURE PROPERTIES OF SELF-COMPACTING, HIGH-PERFORMANCE CONCRETE (1997)

The self-compacting concrete, which was developed in 1988 in Japan, can be filled in a formwork without using any vibrators. It is an effective means of ensuring consistent quality in concrete structures, as the human factor in consolidation can be eliminated. This type of concrete has markedly increased deformability without segregation: high deformability is achieved mainly through the use of superplasticizers, while segregation resistance is achieved mainly through viscosity of the mortar or paste components of the concrete. The focus of this study is on experimental assessment of the effects of each component of concrete mixture in self-compacting concrete on the fresh state.