gebhart/patrepeval huggingface dataset:
The Plasmodium TRAP/MIC2 family member, TRAP-Like Protein (TLP), is involved in tissue traversal by sporozoites (2008)

In the apicomplexan protozoans motility and cell invasion are mediated by the TRAP/MIC2 family of transmembrane proteins, members of which link extracellular adhesion to the intracellular actomyosin motor complex. Here we characterize a new member of the TRAP/MIC2 family, named TRAP-Like Protein (TLP), that is highly conserved within the Plasmodium genus. Similar to the Plasmodium sporozoite protein, TRAP, and the ookinete protein, CTRP, TLP possesses an extracellular domain architecture that is comprised of von Willebrand factor A (vWA) and thrombospondin type 1 (TSP1) domains, plus a short cytoplasmic domain. Comparison of the vWA domain of TLP genes from multiple Plasmodium falciparum isolates showed relative low sequence diversity, suggesting that the protein is not under selective pressures of the host immune system. Analysis of transcript levels by quantitative reverse transcription polymerase chain reaction (RT-PCR) showed that TLP is predominantly expressed in salivary gland sporozoites of P. falciparum and P. berghei. Targeted disruption of P. berghei TLP resulted in a decreased capacity for cell traversal by sporozoites, and reduced infectivity of sporozoites in vivo, whereas in vitro sporozoite motility and hepatocyte invasion were unaffected. These results indicate a role of TLP in cell traversal by sporozoites.
Self Differentiation: A Day with John and Joyce Weir (2000)

(2000). Self Differentiation: A Day with John and Joyce Weir. International Journal of Group Psychotherapy: Vol. 50, No. 1, pp. 126-129.
Mesenchymal Stem Cells for Treatment and Prevention of Graft-Versus- Host Disease After Allogeneic Hematopoietic Cell Transplantation (2009)

Allogeneic hematopoietic cell transplantation (allo-HCT) is an effective therapy for hematological malignancies and inherited diseases. However, acute graft-versus-host-disease (aGVHD) is a major life-threatening complication after allo-HCT and there are few therapeutic options for severe steroid-refractory aGVHD. Preliminary studies on co-transplantation of mesenchymal stem cells (MSCs) have shown an improvement in or resolution of severe aGVHD. However, the mechanism underlying this immunosuppressive effect has not been elucidated. Most of the data suggest that the immunosuppressive effect involves soluble factors such as IL-6 or TGF-beta as well as cell-cell contact dependence. MSCs interact either directly with T cells or indirectly via other immune cells such as dendritic cells and NK cells. Here we review the immunomodulatory function of MSCs in allo-HCT and their potential usefulness in the treatment or prevention of severe acute GVHD.
Novel method for detecting micro-organisms in blood cultures. (1986)

A method for detecting the growth of micro-organisms in blood culture by a visual signal is described. The system utilises a single blood culture medium that has been specifically formulated to support growth of aerobic, anaerobic, and microaerophilic micro-organisms. The system is based on the principle that when micro-organisms grow in the medium in a sealed bottle their metabolic products create positive pressure. This positive pressure displaces the infected blood and broth into an upper chamber, which acts as a visual signal of microbial activity. All the test micro-organisms, when inoculated at less than 20 colony forming units into simulated human blood cultures, gave a positive signal.
Predicted QTL locations for fusarium ear rot (FER) resistance in maize and the generation of improved FER resistant maize inbred lines (2009)

Quantitative trait loci (QTL) found through screening of maize mapping and breeding populations is useful in the selection of quantitative traits such as pathogen resistance. In this study two breeding populations of maize, generated from parents of similar genetic background, were analyzed to predict QTLs associated with fusarium ear rot resistance (FER). The populations were also used to generate FER resistant inbred lines for commercial production and crop improvement. FER is caused by Fusarium verticillioides, which produces harmful mycotoxins in the seed. These mycotoxins can be harmful and even deadly to animals and humans. The FER resistance donor parent NV14FR was crossed with the susceptible parents NV14 and NV35 to create the NV14/NV14FR population and the NV35/NV14FR population. QTL locations were predicted by analyzing the polymorphic markers on the F2 plants for each population and matching the genotypes to the mean scores of the subsequent F2.3 ears. The predicted QTL locations were also matched to previous QTL locations reported in similar studies to support the presence of a QTL in a specific genomic region. One QTL on chromosome 5 (bin 5.05) was predicted from the NV14/NV14FR population which is located in the same region as a previously found QTL. Two QTL were predicted from the NV35/NV14FR population located respectively on chromosome 6 (bin 6.07) and chromosome 7 (bin 7.04). The QTL on chromosome 6 was also found in a genomic region previously identified as important for FER resistance. Three resistant RILs, from the NV14/NV14FR population, were tested in a hybrid combination at 25 locations throughout MN, IL, IA, IN, MI, and WI. The three RILs had improved FER resistance with equal or greater hybrid performance than the isoline check. Marker assisted selection in breeding populations using the QTLs identified in this research will facilitate in the selection for FER resistance.
A Functional NIRS Study of Brain Functional Networks Induced by Social Time Coordination (2019)

The ability to coordinate one's behavior with the others' behavior is essential to achieve a joint action in daily life. In this paper, the brain activity during synchronized tapping task was measured using functional near infrared spectroscopy (fNIRS) to investigate the relationship between time coordination and brain function. Furthermore, using brain functional network analysis based on graph theory, we examined important brain regions and network structures that serve as the hub when performing the synchronized tapping task. Using the data clustering method, two types of brain function networks were extracted and associated with time coordination, suggesting that they were involved in expectation and imitation behaviors.
Pozzolanic activation of metakaolin (1992)

Metakaolin may be calcined without grinding and suitably activated by Ca(OH) 2 , Na 2 SO 4 , CaSO 4 (beta anhydrite) and/or NaOH. The best strengths, 50 MPa from mortar cubes at 18 months, were obtained using Ca(OH) 2 and CaSO 4 activators. The handling and set properties are similar to those of Portland cement; aluminous C-S-H gel is the best binder. All compositions contain K + derived from mineral impurities in kaolin, thus the performance and activation of kaolins may depend partly on their alkali content. The microstructures of the cured products are described, and the importance of good space filling by the hydrates is emphasized. Since the precursor minerals are widely distributed, kaolin deserves more investigation as the principal component of low-energy binder systems.
Thyroid hormone and the cardiovascular system (1997)

Thyroid hormone has profound effects on the heart and peripheral vascular system. This is best demonstrated by the characteristic changes in cardiovascular hemodynamics that accompany both hyper- and hypothyroidism. These effects can be explained by the ability of thyroid hormone to regulate expression of specific cardiac genes as well as to alter systemic vascular resistance. Treatment of the underlying disease process predictably reverses these changes and restores normal cardiovascular physiology. Recent observations suggest therapeutic benefit of thyroid hormone when administered short term to patients who have undergone cardiac surgery and also when given to patients with varying degrees of heart failure. The rapidity of these effects suggests nonnuclear sites of action that may involve membrane ion channel function causing altered myocyte contractility and excitability. This in turn could explain the varied effects of thyroid hormone on cardiac rhythm disturbances and on vascular tone. Thus, the clinical signs and symptoms of thyroid disease are the result of both nuclear and nonnuclear actions of thyroid hormone on the heart and systemic vasculature.
Pathologic staging of renal cell carcinoma (2001)

The revised classification of renal cell carcinoma was a significant predictor of cause specific survival for the cohort of patients described in this report. Using the new system, the stratification of patients was improved. Patients who had their tumors reclassified as a result of the new staging system had outcomes similar to those of patients who had tumors that remained in the same classification. Based on an analysis of this cohort, tumor classification is valid, and the T1 subclassification is warranted. However, additional revision may be required to optimize staging.
Translation of the Ecological Trap Concept to Glioma Therapy: The Cancer Cell Trap Concept (2013)

Viewing tumors as ecosystems offers the opportunity to consider how ecological concepts can be translated to novel therapeutic perspectives. The ecological trap concept emerged approximately half a century ago when it was observed that animals can prefer an environment of low quality for survival over other available environments of higher quality. The presence of such a trap can drive a local population to extinction. The cancer cell trap concept is the translation of the ecological trap into glioma therapy. It exploits and diverts the invasive potential of glioma cells by guiding their migration towards specific locations where a local therapy can be delivered efficiently. This illustrates how an ecological concept can change therapeutic obstacles into therapeutic tools.
Synthesis, conformational analysis and immunological activity of β<sup>3</sup>Phe‐substituted Cyclolinopeptide A analogues (2008)

Abstract CLA, a natural, highly hydrophobic cyclic nonapeptide with sequence c (Pro 1 ‐Pro 2 ‐Phe 3 ‐Phe 4 ‐Leu 5 ‐Ile 6 ‐Ile 7 ‐Leu 8 ‐Val 9 ‐), isolated from linseed oil, was found to possess a strong immunosuppressive activity comparable, in low doses, with that of CsA, with a mechanism that depends on the inhibition of the interleukin‐1 and interleukin‐2 action. Structural analysis of CLA and its related compounds has underlined that the presence of the tetrapeptide Pro‐Pro‐Phe‐Phe sequence, the Pro‐Pro cis amide bond, and the ‘edge‐to‐face’ interaction are possible important features for the immunosuppressive activity of CLA. To evaluate the role and significance of ‘edge‐to‐face’ interaction in the process of molecular recognition by receptors, we have synthesised three linear precursors and three cyclic analogues of CLA, in which one or both Phe residues have been replaced by β 3 Phe residues. A conformational analysis by NMR in CD 3 CN/H 2 O mixture has been carried out on the CLA analogue, in which Phe 3 has been replaced by a βPhe, to study the influence of the mutation on the three‐dimensional structure. All linear and cyclic CLA analogues containing βPhe have been tested in the humoral and cellular immune response in vivo assays in mice. The peptide activities have been compared with CsA, as a reference drug. Copyright © 2008 European Peptide Society and John Wiley & Sons, Ltd.
Anti-implantation Effect of a Carbamate Fungicide Mancozeb in Albino Mice. (2002)

Mancozeb, an organocarbamate fungicide, was administered to examine the effect on implantation at doses of 18, 24, 30 and 36 mg/kg body weight/d to normal virgin swiss albino mice for 8 days to pregnant mice. The vaginal smear and body weight of the mice were recorded daily and mice were sacrificed on 9th day of pregnancy. There was a complete inhibition of implantation in 36 mg mancozeb treated mice with 100% pre-implantation loss. There was a partial inhibition of implantation in 24 and 30 mg mancozeb treated mice with 53.44 and 90.16% pre-implantation loss respectively. However, implantation was not affected in 18 mg mancozeb treated mice with 4.92% pre-implantation loss when compared to oil treated controls. To study the temporal effect, the effective dose of 36 mg/kg body weight/d mancozeb was administered orally for 3 and 5 days and on day 3 only. There was a complete inhibition of implantation in 5 days treated mice with 100% pre-implantation loss and partial inhibition of implantation of 3 days treated mice with 75% pre-implantation loss. However, implantation was not affected in mice treated on day 3 only with 1.63% pre-implantation loss when compared to control mice. There was a significant decrease in the diestrus phase with the result there was a concomitant increase in the estrus phase and there was a significant decrease in the uterus weight with 24, 30 and 36 mg and for 3 and 5 days with 36 mg mancozeb treatment. Inhibition of implantation by mancozeb may be due to hormonal imbalance or its toxic effects.
An operational rate control scheme for H.264 with two-stage encoding (2005)

An operational rate control (RC) scheme based on two-stage encoding is studied in this research, where frame-layer rate control with a constant bit rate to achieve constant video quality is examined. In the first encoding stage, the R-D optimized mode decision and its associated motion estimation (RDO) as well as DCT/Q, IQ/IDCT and entropy coding are performed for all macroblocks (MBs) for a target frame using an initial quantization parameter (QP), which is the QP of its previous frame. In the second encoding stage, the residual signal from the first stage is encoded using several QP values around the initial QP. Given the target bits and distortion for the current frame, the residual signal is finally encoded using the QP determined by comparing target bits and distortion with actual bits and distortion. To reduce the additional coding complexity of the two-stage encoding, upper and lower bounds around target bits and distortion are employed to reduce the number of encoding required in the second stage. Experimental results are given to show the superior performance of two proposed rate control algorithms, where one targets at the constant bit rate while the other at constant quality.
Synthesis and Modification of Alternating Copolymers Based on Vinyl Ethers, Chlorotrifluoroethylene, and Hexafluoropropylene (2009)

Fluorinated copolymers bearing ammonium groups were prepared by radical copolymerization of fluorinated olefins (chlorotrifluoroethylene, hexafluoropropylene) with different vinyl ethers (2-chloroethyl, cyclohexyl, n-butyl, and ethyl vinyl ethers) followed by the cationization of these copolymers with trimethylamine. Copolymers were obtained in high yield (generally >85%), with molecular weights ranging from 8000 to 25 000 g mol−1. From elemental analysis as well as 1H and 19F NMR spectroscopy, the alternating structure of these polymers was confirmed. The chemical modification of these copolymers consisted of a two-step reaction: (i) the replacement of the chlorine atom by an iodine atom followed by (ii) the substitution of the halogen atom by the trimethylamine into a quaternary ammonium. The resulting copolymers were characterized with the usual techniques to assess their compositions and structures. Their thermal analyses, in dynamic mode, under air, showed decomposition temperatures (Td,10%) higher than 200 °C. Electrochemical properties of some of these polymers were also studied, showing ionic exchange capacities (IEC) ranging from 0.50 to 0.75 mequiv g−1 (theoretical IEC up to 3.63 mequiv g−1) and water uptake of 13−25%.
Spontaneous locomotor recovery in spinal cord injured rats is accompanied by anatomical plasticity of reticulospinal fibers (2006)

Although injured axons in mammalian spinal cords do not regenerate, some recovery of locomotor function following incomplete injury can be observed in patients and animal models. Following a lateral hemisection injury of the thoracic spinal cord, rats spontaneously recover weight-bearing stepping in the hind limb ipsilateral to the injury. The mechanisms behind this recovery are not completely understood. Plasticity in the reticulospinal tract (RtST), the tract responsible for the initiation of walking, has not been studied. In this study, rats received lateral thoracic hemisection of the spinal cord, and RtST projections were compared in two groups of rats, one early in recovery (7 days) and the other at a time point when weight-bearing stepping was fully regained (42 days). We found that this recovery occurs in parallel with increased numbers of collaterals of spared RtST fibers entering the intermediate lamina below the injury at L2. Sprouting of injured RtST fibers above the lesion was not found. In conclusion, our study suggests that sprouting of spared RtST fibers might be involved in the recovery of locomotion following incomplete spinal cord injury.
Catalytic reactivity and stereospecificity of organometallic compounds in olefin polymerization (1959)

Abstract Catalytic reactivity of organometallic compounds in olefin polymerization is discussed on the basis of the electronegativity of the metal. The transition metal compounds seem to participate in the polymerization as Lewis acids which facilitate the addition of an aluminum alkyl by a concerted mechanism. A mechanism for the stereospecific polymerization is advanced in which hindered rotation around the terminal CC bond in the growing polymer and a specific orientation of a monomer to the polymer chain are assumed.
Abstract 19378: First Experience with Concomitant AT1 and Neprilysin (NEP 24.11) Inhibition with LCZ696 in Patients with Chronic Heart Failure (2010)

Introduction: In the setting of heart failure (HF), chronic RAAS activation is detrimental, while NEP (neprilysin, NEP 24.11) activation is expected to induce a beneficial response. LCZ696, an angiotensin receptor neprilysin inhibitor (ARNI), offers the synergy of concomitant angiotensin II AT1 receptor and neprilysin enzyme inhibition. We report the first results of LCZ696 in patients with stable chronic HF, exploring the tolerability of LCZ696. Methods: Patients with stable HF (NYHA II-IV, LVEF <40), on optimal medical therapy entered an open-label study. After a short washout of ACEI therapy, patients were treated with LCZ696 100 mg BID for 7 days and then uptitrated to 200 mg BID for an additional 14 days, maintaining other chronic stable background therapy. Patients remained in the clinic during the study period. Results: Thirty patients (NYHA II 56%, LVEF 33.6±4.6%, male 83.3%, BMI 30.7±4.6kg/m2) entered the study. Background treatment included θ-blockers (90%), ASA (90%), statin (50%), aldosterone ...
T Cell Costimulation Blockade Blunts Age-Related Heart Failure (2020)

Supplemental Digital Content is available in the text.
Synthesis and Properties of Polypyrrole/Chitosan Composite Hydrogels (2013)

Conducting polymer hydrogels consisting of polypyrrole (PPy) and chitosan (CS) are prepared by static polymerization of pyrrole using methyl orange (MO) as the dopant and Fe2(SO4)3 as the oxidant in the CS aqueous solution. PPy/CS composite hydrogels not only have good electrical conductivities, but also exhibit excellent swelling/deswelling behaviors due to the participation of one-dimensional conducting PPy blocks in the hydrogel network. The effects of the amount of the oxidant and ionic strength on the physical properties of PPy/CS composite hydrogels are studied in detail. The results show that PPy/CS composite hydrogels have improved water absorbencies in saline solutions compared with the conventional polyelectrolyte hydrogel.
Explore the Experience Design of Taiwan's "Creative Living Industry" - An Example of Nanyuan * (2015)

Due to the structural change of world economy and technological advances, development in a competitive global market further needs creativity and special characteristics. Marketing and in response to the changing economic trends, also convert from function-oriented to consumer-oriented. Meanwhile, Taiwan in recent years also enters the post-modern era of consumption. When making purchases, consumers not only consider satisfying their basic material needs, but also trying to pursue sensual and symbolic value and further pursuing the creation of self-efficacy to obtain the satisfaction of psychological needs. Therefore, the creative living industry, combining the three elements in core knowledge, indepth and aesthetics, is born. This study uses Nanyuan, the first in Taiwan introducing creative living industry and marketing in its business philosophy, as the object of study and uses Evaluation Grid Method (EGM) of Miryoku Engineering to conduct in-depth interviews of 4 practitioners with high involvement and 5 consumers, and then obtains an evaluation grid map based on the interview results. Five original attractiveness facctors of Nanyuan are natural environment, architectural space, service design, product and brand This study finds that the operating personnel and the consumers are highly consistent in their perceptions of the first four attractiveness factors. As for brand marketing, the two sides show considerable differences in their views of whether the degree of commercialization is conducive to marketing. The results of this study can be provided as a reference for the business planning of Nanyuan, and at the same time, provides recommendation on the experience design of the business planning in the future to the practitioners who wish to invest in the creative living industry.
Automobile technology of the future (1991)

Technical advances should make it possible to improve all significant qualities of the automobile - space, comfort, reliability, performance, fuel economy, safety and environmental compatibility. That's the prediction delivered by Ulrich Seiffert and Peter Walzer in Automobile Technology of the Future, a publication focusing on forthcoming technological developments in the automotive field. Seiffert and Walzer chronicle new technology which will impact the way automobiles are designed, manufactured and marketed globally at the turn of the century/millenium. The book examines which drive train concepts, vehicle components, materials, chassis and transmissions will be technically feasible. Engine development and environmental
Interleukin-1-induced granulocytopenia and pulmonary leukostasis in rabbits (1987)

Pulmonary leukostasis is a postulated prerequisite lesion for acute lung injury. Interleukin-1 (IL-1) mediates components of the acute-phase response, stimulates granulocyte metabolism and secretion, and augments endothelial adhesiveness. We studied the effects of murine IL-1 infusion on circulating granulocytes, their sequestration within the pulmonary microvasculature, lung water, and bronchoalveolar lavage fluid (BALF) protein concentration in rabbits at 3 and 24 h after infusion. IL-1 administration induced significant (P less than 0.01) granulocytopenia compared with saline-injected controls and at 3 h induced significant increases in both mean alveolar septal wall granulocytes per high power field (HPF) (P less than 0.001) and mean myeloperoxidase (MPO) activity per gram lung tissue (P less than 0.001). At 24 h, IL-1 induced a marked granulocytosis and again significantly increased both mean alveolar septal wall granulocytes per HPF (P less than 0.001) and lung MPO (P less than 0.01). Increased lung water or BALF protein concentration could not be demonstrated in animals killed at either 3 or 24 h after IL-1 administration. Therefore, IL-1 can induce an early profound granulocytopenia followed by later granulocytosis, as well as sustained pulmonary leukostasis in the absence of detectable pulmonary edema formation or an alveolar-capillary leak.