gebhart/patrepeval huggingface dataset:
Trust-based privacy preservation for peer-to-peer data sharing (2006)

Privacy preservation in a peer-to-peer (P2P) system tries to hide the association between the identity of a participant and the data that it is interested in. This paper proposes a trust-based privacy-preservation method for P2P data sharing. It adopts the trust relation between a peer and its collaborators (buddies). The buddy works as a proxy to send the request and acquire the data. This provides a shield under which the identity of the requester and the accessed data cannot be linked. A privacy measuring method is presented to evaluate the proposed mechanism. Dynamic trust assessment and the enhancement to supplier's privacy are discussed
Effect of mutation of amino acids 246–251 (KRKHKK) in HSP72 on protein synthesis and recovery from hypoxic injury (2005)

Heat shock protein (HSP)72, the inducible form of HSP70, protects cells against a variety of injuries, but underlying mechanisms are poorly defined. To investigate the protective effects of HSP72, multiple clones expressing wild-type (WT) HSP72 and two mutants with defective nucleolar and nuclear localization (M45 and 985A, respectively) were made with the tet-off system in C2C12 cells. Four different parameters of cell function/injury were examined after simulated ischemia: protein synthesis, polysome formation, DNA synthesis, and lactate dehydrogenase (LDH release). Overexpression of WT HSP72 was also compared to nontransfected C2C12 cells. As expected, overexpression of HSP72 protected against simulated ischemia and reoxygenation for all parameters. In contrast, both M45 and 985A showed abnormal protein synthesis and polysome formation, both after simulated ischemia and under control conditions. Total RNA was slightly reduced in M45 and 985A at baseline, but 1 h after hypoxia, RNA levels were protected in all clones but significantly decreased in nontransfected C2C12 cells. Clones expressing 985A had nuclear retention of mRNA, suggesting that HSP72 is needed for nuclear export of RNA. All clones, both WT and mutant, had protection of DNA synthesis compared to C2C12 cells, but 985A had greater release of LDH after injury than any other group. These results support a multifactoral protective effect of HSP72, some aspects dependent on nuclear localization with stress and some not. The protection of protein synthesis and polysome formation, and abnormalities in these with the mutants, support a role for HSP72 in these processes both in the normal cell and in injury.
Enzymatic degradation of urinary indoxyl sulfate by Providencia stuartii and Klebsiella pneumoniae causes the purple urine bag syndrome (1988)

The etiology of the purple urine bag syndrome (PUBS), in which the urinary catheter bag of some elderly patients develops intense purple coloration, was studied. The purple was found to be a mixture of indirubin dissolved in the plastic and indigo on its surface. Six patients with PUBS were studied, and Providencia stuartii was isolated from the urine of five and Klebsiella pneumoniae was isolated from the urine of one. These strains produced indigo in 7.9 mM indoxyl sulfate-containing agar. One hundred and fifty isolates of 41 species of bacteria were tested for their ability to produce indigo on agar containing indoxyl sulfate, but only 17 of 27 strains of P. stuartii, a single strain of Klebsiella pneumoniae, and Enterobacter agglomerans were positive. All of the indigo-producing bacteria had an indoxyl phosphatase with a pI of 6.4. This enzyme also possessed indoxyl sulfatase activity and was not present in strains that were unable to produce indigo from indoxyl sulfate. We conclude that PUBS results from the decomposition of urinary indoxyl sulfate to indigo and indirubin by bacteria (notably P. stuartii). As elderly catheterized patients often have high urinary indoxyl sulfate levels and colonization of their urinary tract with P. stuartii, the condition is most commonly seen in them.
Polymer Nanowire Arrays With High Thermal Conductivity and Superhydrophobicity Fabricated by a Nano-Molding Technique (2012)

High thermal conductivity is helpful for thermal control and management, and superhydrophobicity can benefit fluid friction reduction and liquid droplet control in micro-/nanodevices. We report on a nano-molding technique that can prepare polyethylene nanowire arrays with high thermal conductivity (more than 10 W/m-K) and superhydrophobicity (contact angle >150°). The thermal conductivities of the fabricated high-density polyethylene nanowire arrays with diameters of 100 nm and 200 nm, measured by a laser flash method, are about 2 orders of magnitude higher than their bulk counterparts. The estimated thermal conductivity of a single high-density polyethylene nanowire is as high as 26.5 W/m-K at room temperature, while the thermal conductivity of low-density polyethylene nanowire is a little smaller. The self-organized surfaces of polymer nanowire arrays are found to have micro-to-nanoscale hierarchical nanostructures, and have superhydrophobicity of greater than 150° contact angles for water. We also measure the wettability of organic liquids, including glycerin, ethanol, paraffin liquid, and methyl silicone oil. We find glycerin gives hydrophobic wettability, but the others give hydrophilic wettabilities. This technique is promising for fabrication due to the advantages of simple fabrication, high quality, low cost, and mass production.
Experimental Research on Gas Holdup in Bubble Disintegration Process (2009)

Pressure difference method with the sudden-stoppage technique was applied to examine respectively the effects of different factors on local gas holdup under centric and eccentric stirring,and the changes of local gas holdup along the radial under centric and eccentric stirring. The results showed that centric forward-reverse and eccentric stirring modes could improve gas holdup,and the latter more effectively. Local gas holdup could be improved by forward-reverse rotation under centric stirring. Gas holdup near water model wall increased with increasing of gas flow rate under any kind of stirring mode. Local gas holdup decreased with increasing of radial distance under centric stirring,but fluctuated with radial distance under eccentric stirring. Average gas holdup increased with increasing of gas flow rate under both centric and eccentric stirring. Average gas holdup increased with increasing of rotation speed under eccentric stirring,but decreased with increasing of rotation speed under centric stirring.
Direct healthcare costs and predictors of costs in patients with primary Sjogren's syndrome (2006)

This is the first study to evaluate direct healthcare costs in patients with PSS. PSS has a significant impact on the healthcare system, similar to that of RA, by more than doubling costs compared with control patients.
Heart failure therapy mediated by the trophic activities of bone marrow mesenchymal stem cells: a noninvasive therapeutic regimen (2009)

Heart failure carries a poor prognosis with few treatment options. While myocardial stem cell therapeutic trials have traditionally relied on intracoronary infusion or intramyocardial injection routes, these cell delivery methods are invasive and can introduce harmful scar tissue, arrhythmia, calcification, or microinfarction in the heart. Given that patients with heart failure are at an increased surgical risk, the development of a noninvasive stem cell therapeutic approach is logistically appealing. Taking advantage of the trophic effects of bone marrow mesenchymal stem cells (MSCs) and using a hamster heart failure model, the present study demonstrates a novel noninvasive therapeutic regimen via the direct delivery of MSCs into the skeletal muscle bed. Intramuscularly injected MSCs and MSC-conditioned medium each significantly improved ventricular function 1 mo after MSC administration. MSCs at 4 million cells/animal increased fractional shortening by approximately 40%, enhanced capillary and myocyte nuclear density by approximately 30% and approximately 80%, attenuated apoptosis by approximately 60%, and reduced fibrosis by approximately 50%. Myocyte regeneration was evidenced by an approximately twofold increase in the expression of cell cycle markers (Ki67 and phosphohistone H(3)) and an approximately 13% reduction in mean myocyte diameter. Increased circulating levels of hepatocyte growth factor (HGF), leukemia inhibitory factor, and macrophage colony-stimulating factor were associated with the mobilization of c-Kit-positive, CD31-positive, and CD133-positive progenitor cells and a subsequent increase in myocardial c-Kit-positive cells. Trophic effects of MSCs further activated the expression of HGF, IGF-II, and VEGF in the myocardium. The work highlights a cardiac repair mechanism mediated by trophic cross-talks among the injected MSCs, bone marrow, and heart that can be explored for noninvasive stem cell therapy.
The control of variable-speed wind turbine generators (1983)

The problem of smooth control of electrical power from a large wind turbine generator to an electrical utility system grid is discussed. A control system is proposed which is applicable to either induction or synchronous machines asynchronously coupled to the grid through a controllable DC current link. A power limiting strategy is developed which spills powers at high wind velocities without recourse to blade pitch control mechanisms.
Continuous Amination of Propanediols in Supercritical Ammonia (1999)

Enhancements in selectivity by a factor of 4 to 18 were observed in the near critical regions of ammonia during the Co- and Ni-catalyzed synthesis of 1,3-diaminopropanes. These results are attributed to the higher concentration of ammonia at the surface of the catalyst, which favors the amination and suppresses degredation reactions.
Preparation of High-Purity Silicon from Silane (1961)

The preparation, purification, and thermal decomposition of silane, , were investigated for the purpose of preparing high‐purity silicon. Quantitative yields of silane were obtained by the reduction of silicon tetrachloride with lithium aluminum hydride. Variables in the thermal decomposition of silane were evaluated with regard to purity of the elemental silicon produced and the efficiency of dissociation and deposition rate. Silane was dissociated on an inductively heated single crystal silicon substrate to yield high‐purity silicon. Neutron activation analyses for microcrystalline high‐purity silicon as deposited are given.
Does early repolarization in the athlete have analogies with the Brugada syndrome? (2001)

Early repolarization is almost always the rule in athletes but it is also frequent in sedentary males. Tracings somewhat simulating the Brugada syndrome were observed in only 8% of athletes without a history of syncope or familial sudden death. Significant differences exist between athletes with early repolarization and patients with the Brugada syndrome as regards the amplitude of ST elevation and QRS duration.
Regioselective N-Functionalization of Tetraazacycloalkanes (2005)

Bisaminal type compounds obtained by condensation of pyruvic aldehyde with the suitable open-chain tetraamine followed by cyclization with either dibromoethane or dibromopropane can be regioselectively quaternized by a wide range of alkylating agents. Removal of the bisaminal bridge yields the monosubstituted tetraazamacrocycle or bismacrocycle. Further functionalization allows the preparation of bifunctional ligands or trisubstituted macrocycles. The structure of six compounds was solved by X-ray diffraction, and the unexpected results are rationalized according to the molecular modeling calculations.
Hierarchical evolutionary game based dynamic cloudlet selection and bandwidth allocation for mobile cloud computing environment (2018)

To bridge the gap between the resource‐constrained mobile devices and the resource‐demanding applications, mobile cloud computing (MCC) emerges for offloading complex tasks to a cloud server. Based on this concept, cloudlets, which move available resource to the vicinity of the mobile network, enhance further the system accessibility and performance. Moreover, to strengthen the network capacity in traffic intensive area, dense small cell network (DSCN) is proposed as one of the promising solutions. In this study, the operation of cloudlets and DSCN is collaboratively studied in order to further improve the system performance. On the one hand, users can select a cloudlet and dynamically adapt the connection according to the performance and the cost, which is referred to as a user‐essential dynamic cloudlet selection problem. On the other hand, a cloudlet needs to set the optimal selling price and the size of resource for the users, which is considered as a cloudlet resource allocation problem. To jointly address the problems of dynamic cloudlet selection and resource allocation, the authors propose a hierarchical evolutionary game to maximise the utilities. Simulation studies are carried out to demonstrate the effectiveness of the proposed algorithms, which, indeed, improve the entire system performance significantly.
Neural systems subserving valence and arousal during the experience of induced emotions. (2010)

The circumplex model of affect construes all emotions as linear combinations of 2 independent neurophysiological dimensions, valence and arousal. We used functional magnetic resonance imaging to identify the neural networks subserving valence and arousal, and we assessed, in 10 participants, the associations of the BOLD (blood oxygen level-dependent) response, an indirect index of neural activity, with ratings of valence and arousal during the emotional experiences induced by the presentation of evocative sentences. Unpleasant emotional experience was associated with increased BOLD signal intensities in the supplementary motor, anterior midcingulate, right dorsolateral prefrontal, occipito-temporal, inferior parietal, and cerebellar cortices. Highly arousing emotions were associated with increased BOLD signal intensities in the left thalamus, globus pallidus, caudate, parahippocampal gyrus, amygdala, premotor cortex, and cerebellar vermis. Separate analyses using a finite impulse response model confirmed these results and revealed that pleasant emotions engaged an additional network that included the midbrain, ventral striatum, and caudate nucleus, all portions of a reward circuit. These findings suggest the existence of distinct networks subserving the valence and arousal dimensions of emotions, with midline and medial temporal lobe structures mediating arousal and dorsal cortical areas and mesolimbic pathways mediating valence.
Study of Bovine Serum Albumin Solubility in Aqueous Solutions by Intrinsic Viscosity Measurements (2013)

The behavior of bovine serum albumin (BSA) in water is scarcely studied, and the thermodynamic properties arising from the experimental measurements have not been reported. Intrinsic viscosity measurements are very useful in assessing the interaction between the solute and solvent. This work discussed in a simple determination of the enthalpy of BSA in aqueous solution when the concentration ranges from 0.2 to 36.71% wt. and the temperature from 35 to<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:msup><mml:mrow><mml:mn>40</mml:mn></mml:mrow><mml:mrow><mml:mo>°</mml:mo></mml:mrow></mml:msup></mml:mrow></mml:math>C. The relationship between the concentration and intrinsic viscosity is determined according to the method of Huggins. The temperature increase reduces the ratio between inherent viscosity and concentration (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M2"><mml:msub><mml:mrow><mml:mi>η</mml:mi></mml:mrow><mml:mrow><mml:mi>i</mml:mi></mml:mrow></mml:msub><mml:mo>/</mml:mo><mml:mi>c</mml:mi></mml:math>). This is reflected in the Van't Hoff curve. Furthermore, this work proposes hydrodynamic cohesion value as an indicator of the degree of affinity of protein with water and thermodynamic implications in conformational changes.
Evolutionary Convolutional Neural Network Optimization with Cross-Tasks Transfer Strategy (2021)

Convolutional neural networks (CNNs) have shown great success in a variety of real-world applications and the outstanding performance of the state-of-the-art CNNs is primarily driven by the elaborate architecture. Evolutionary convolutional neural network (ECNN) is a promising approach to design the optimal CNN architecture automatically. Nevertheless, most of the existing ECNN methods only focus on improving the performance of the discovered CNN architectures without considering the relevance between different classification tasks. Transfer learning is a human-like learning approach and has been introduced to solve complex problems in the domain of evolutionary algorithms (EAs). In this paper, an effective ECNN optimization method with cross-tasks transfer strategy (CTS) is proposed to facilitate the evolution process. The proposed method is then evaluated on benchmark image classification datasets as a case study. The experimental results show that the proposed method can not only speed up the evolutionary process significantly but also achieve competitive classification accuracy. To be specific, our proposed method can reach the same accuracy at least 40 iterations early and an improvement of accuracy for 0.88% and 3.12% on MNIST-FASHION and CIFAR10 datasets compared with ECNN, respectively.
Plasma levels of substance P, neuropeptide Y and vasoactive intestinal polypeptide in patients with chronic tension-type headache (1999)

Animal and human studies have shown that substance P (SP), neuropeptide Y (NPY) and vasoactive intestinal polypeptide (VIP) are involved in the pathophysiology of acute and chronic pain conditions. The primary aim of the present study was to compare plasma levels of SP, NPY and VIP in external jugular vein between patients with chronic tension-type headache and healthy controls. The secondary aim was to examine plasma levels of these neuropeptides in relation to headache state. In addition, we wanted to study the relation between cranial circulation (jugular vein) and peripheral circulation (antecubital vein). Blood from the external jugular and antecubital vein was drawn from 20 patients with chronic tension-type headache and 20 healthy controls. Plasma SP in patients, 2.0 (1.4-2.2) pmol/l, did not differ significantly from plasma SP in controls, 1.7 (1.1-2.1) pmol/l, (P=0.44). No significant differences were found between SP levels on days with headache, 1.5 (0.3-1.7) pmol/l, and SP levels on days without headache, 1.7 (1.1-1. 9) pmol/l, (P=0.06). Plasma NPY in patients, 118+/-3 pmol/l, did not differ significantly from plasma NPY in controls, 113+/-5 pmol/l, (P=0.40). There was no difference between NPY levels on days with headache, 120+/-3 pmol/l, and on days without headache, 118+/-3 pmol/l, (P=0.73). VIP levels in patients, 6 (4-7) pmol/l, did not differ significantly from VIP levels in controls, 5 (5-7) pmol/l, (P=0.50). No significant differences were found between VIP levels measured on days with headache, 5 (4-6) pmol/l, and VIP levels measured on days without headache, 6 (4-7) pmol/l, (P=0.81). Plasma levels of SP, NPY and VIP did not significantly differ between the peripheral and the cranial circulation neither in patients nor in controls (0.05). In summary, the present study indicates that plasma levels of SP, NPY and VIP are normal in chronic tension-type headache patients and largely unrelated to headache state.
Cabernet (2008)

Deploying and managing wide-area network services is exceptionally challenging. Despite having servers at many locations, a service provider must rely on an underlying best-effort network; a network provider can offer services over its own customized network, but only within limited footprint. In this paper, we propose Cabernet (Connectivity Architecture for Better Network Services), a three-layer network architecture that lowers the barrier for deploying wide-area services. We introduce the connectivity layer, which uses virtual links purchased from infrastructure providers to run virtual networks with the necessary geographic footprint, reliability, and performance for the service providers. As an example, we present a cost-effective way to support IPTV delivery through wide-area IP multicast that runs on top of a reliable virtual network.
Architectural considerations for playback of quality adaptive video over the Internet (2002)

Lack of QoS support in the Internet has not prevented the rapid growth of streaming applications. However many of these applications do not perform congestion control effectively. Thus there is significant concern about the effects on co-existing well-behaved traffic and the potential for congestion collapse. In addition, the majority of such applications are unable to perform quality adaptation on-the-fly as the available bandwidth changes during a session. This paper provides some architectural insights on the design of video playback applications in the Internet. We present fundamental design principles for Internet applications and identify end-to-end congestion control, quality adaptation and error control as the three major building blocks for Internet video playback applications. We discuss the design space for each of these components, and within that space, present an end-to-end architecture suited for playback of layered-encoded stored video streams. Our architecture reconciles congestion control and quality adaptation which occur on different timescales. It exhibits a TCP-friendly behavior by adopting the RAP protocol for end-to-end congestion control. Additionally it uses a layered framework for quality adaptation with selective retransmission to maximize the quality of the delivered stream as the available bandwidth changes. We argue that the architecture can be generalized by replacing the suggested mechanism for each component by another from the same design space as long as all components remain compatible.
Dynamic redistribution of STAT1 protein in IFN signaling visualized by GFP fusion proteins (1999)

STAT proteins (signal transducers and activators of transcription) are a family of transcription factors which are used by many cytokines and cell growth factors for initiating gene expression. They are activated by tyrosine phosphorylation through the cytoplasmic domain of stimulated receptors. Upon phosphorylation STAT proteins dimerize, translocate to the nucleus and activate transcription by binding to specific recognition sites. Different cytokines activate different subsets of STATs and other signaling proteins. We have made use of green fluoresencent protein (GFP) fusion proteins to visualize the subcellular localization and trafficking of STAT1, STAT2 and p48 during interferon (IFN) stimulation and have analysed in detail STAT1-GFP trafficking in living cells. Analysis of GFP fusion proteins allowed the determination of time kinetics of subcellular trafficking in individual living cells. STAT1-GFP is indistinguishable from its wild-type protein displaying strong activity as transcriptional activator as well as the same time kinetics of transport to the nucleus and retreat to the cytoplasm. After prolonged exposure to IFN, STAT1-GFP is no longer retained in the nucleus and relocation to the cytoplasm is observed. Restimulation with the same type of IFN does not lead to repeated nuclear translocation of STAT1-GFP. STAT1 is not subject of inhibition, as restimulation with another type of IFN allows immediate reuse of previously activated STAT1-GFP. However, restimulation with the same type of IFN can be achieved when the primary stimulus is removed after a short induction period. This method of visualizing signal transduction reveals a considerable inhomogeneity with respect to the extent of STAT1-GFP shuttling within a clonal cell population, indicating that competence for full-blasted IFN response is restricted to a cellular subpopulation whereas other cells respond incompletely, retarded or not at all.