gebhart/patrepeval huggingface dataset:
Identification of Removal Mechanisms for Lead in Granular Activated Carbon (GAC) Columns (1995)

Abstract In an earlier study the removal of lead by a granular activated carbon (GAC) column was increased by over 600% when the carbon [Hydrodarco 4000 (HD4000), Norit Americas, Inc.] was contacted with a 0.1 N HNO3-0.1 N NaOH rinse. Hypothesized removal mechanisms were adsorption, surface preceipitation, and pore precipitation. In this work a series of experiments were conducted on samples of the virgin and acid-base rinsed carbon to determine their acid-base behavior. pHzpc, and Pb removal ability. If adsorption was a dominant removal mechanism, then significant differences in these parameters for the virgin and acid-base rinsed carbons would be expected. The strong acid-base rinse did not significantly alter the acid-base behavior, pHzpc, or the Pb removal ability compared to virgin HD4000. Thus, it appears that the dramatic increase in metal removal by the regenerated GAC columns was not caused by an increase in the number or type of adsorption sites but was due to the precipitation of Pb on the carbon surface or in the carbon pore liquid. Future research efforts will focus on the modeling of Pb removal in GAC columns using precipitation as the primary removal mechanism.
Bone‐bonding ability of a hydroxyapatite coated zirconia–alumina nanocomposite with a microporous surface (2006)

Using a combination of hydroxyapatite (HA) coating and microporous surface treatment, bone-bonding ability was given to composites of ceria-stabilized tetragonal zirconia and alumina (CZA), which possesses excellent mechanical and wear properties and phase stability. Four types of CZA plates (2 x 10 x 15 mm3) were prepared for this study, which were CZA with a polished surface (group 1), a microporous surface prepared by hydrofluoric acid and heat treatment (group 2), a microporous surface with a submicron HA coating prepared by alternately soaking the plate from group 2 in aqueous CaCl2/HCl and Na2HPO4 solutions (group 3), and a microporous surface with a 4-microm HA coating prepared by the biomimetic method, where the plates from group 3 were soaked in simulated body fluid (group 4). Plates were implanted into rabbit tibia, and after 4, 8, and 16 weeks, tensile testing and histological examination of the bone-implant interface were conducted. At 4 weeks, group 4 had superior bone-bonding ability compared with other implants, which was maintained at the later postimplantation times. This HA-coated CZA with a microporous surface has the possibility of clinical use as a bearing material in cementless joint prostheses or as a load-bearing bone substitute.
A Compact Compensated Resistivity Tool for Logging While Drilling (2006)

Abstract A new method and tool design for borehole compensated electromagnetic propagation resistivity logging while drilling (LWD) are presented. The method provides borehole compensated resistivity measurements at multiple depths of investigation using a shorter antenna array than existing compensation methods. The compact array is typically 40% shorter than conventional antenna arrays for borehole compensated measurements, resulting in a shorter, lower cost bottom hole assembly (BHA). This paper presents the theoretical basis of the compact array design, as well as electromagnetic modeling results demonstrating performance in downhole conditions of interest. Results from field tests of a downhole tool are also presented. The compact array design has been applied to create a shorter, lower cost resistivity logging while drilling collar. The three resistivity measurements enable determination of true resistivity (Rt), diameter of invasion, and flushed zone resistivity (Rxo) while drilling, geosteering, and formation evaluation in horizontal or deviated wells where application of wireline tools is difficult. The initial downhole antenna array design is some 44% shorter than equivalent conventional antenna arrays for borehole compensated measurements. Electromagnetic modeling results are presented for the three-receiver and two-transmitter antenna array to demonstrate performance of the shallow, medium, and deep resistivity outputs from phase-difference measurements. Modeling and field test data are used to show equivalent performance of the compact array to existing compensated antenna arrays in rugose boreholes and at bed boundaries. Modeling results are also presented which demonstrate the limitations and advantages of multi-frequency operation. Test data for a new method for compensation of electronics error are also shown. The paper presents a new approach to LWD borehole compensated resistivity methods that reduces the overall length of the antenna array and associated cost. The compact antenna array provides improved invasion profiling and determination of true resistivity when compared to existing borehole compensated array designs.
Solid state reactions involving oxides of trivalent cations (1961)

Selected mixtures in 69 binary systems involving Al<sub>2</sub>O<sub>3</sub>, Ga<sub>2</sub>O<sub>3</sub>, Cr<sub>2</sub>O<sub>3</sub>, Fe<sub>2</sub>O<sub>3</sub>, Sc<sub>2</sub>O<sub>3</sub>, In<sub>2</sub>O<sub>3</sub>, Y<sub>2</sub>O<sub>3</sub>, and the rare earth oxides were studied by X-ray diffraction techniques after heat treatment at various temperatures. A plot of the radii of the A<sup>+3</sup> cations versus the radii of B<sup>+3</sup> cations shows the regions of stability for the different structure types found for the double oxides of the trivalent cations. The following structure types were encountered: A, B, and C-type rare earth oxide; corundum, beta gallia; kappa alumina; garnet; perovskite; and several types which could not be definitely related to known structures. The majority of A<sup>+3</sup>B<sup>+3</sup>O<sub>3</sub> compounds have the perovskite structure. Several phases, including (1-<i>x</i>)Fe<sub>2</sub>O<sub>3</sub>·<i>x</i>Al<sub>2</sub>O<sub>3 ss</sub> and (1-<i>x</i>)Fe<sub>2</sub>O<sub>3</sub>·Ga<sub>2</sub>O<sub>3 ss</sub>, appear to have structures similar to kappa alumina. Solid solution definitely occurs in many of the garnet type compounds which contain gallia. Based on the data collected in this survey, the subsolidus phase equilibria relationships of 79 binary systems were drawn.
A 1 V Wireless Transceiver for an Ultra-Low-Power SoC for Biotelemetry Applications (2008)

This paper presents a 1 V RF transceiver for biotelemetry and wireless body sensor network (WBSN) applications, realized as part of an ultra low power system-on-chip (SoC), the Sensiumtrade. The transceiver utilizes FSK/GFSK modulation at a data rate of 50 kbit/s to provide wireless connectivity between target sensor nodes and a central base-station node in a single-hop star network topology operating in the 862-870 MHz European short-range-device (SRD) and the 902-928 MHz North American Industrial, Scientific & Medical (ISM) frequency bands. Controlled by a proprietary media access controller (MAC) which is hardware implemented on chip, the transceiver operates half-duplex, achieving -102 dBm receiver input sensitivity (for 1E-3 raw bit error rate) and up to -7 dBm transmitter output power through a single antenna port. It consumes 2.1 mA during receive and up to 2.6 mA during transmit from a 0.9 to 1.5 V supply. It is fabricated in a 0.13 mum CMOS technology and occupies 7 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> in a SoC die size of 4 times 4 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> .
CHARLA CON EL ARQUITECTO FERNANDO GONZÁLEZ CORTÁZAR (2013)

EL MUSEO UNIVERSITARIO DEL CHOPO INICIA UNA ETAPA DE VINCULACION CON LA COMUNIDAD UNIVERSITARIA. EN UNA DE LAS PRIMERAS ACTIVIDADES, EN EL FORO DEL DINOSAURIO JUAN JOSE GURROLA SE EFECTUO UNA CHARLA ENTRE EL RECONOCIDO ARQUITECTO FERNANDO GONZALEZ GORTAZAR, PREMIO NACIONAL DE CIENCIAS Y ARTES 2012 Y EMILIO CANEK FERNANDEZ, COORDINADOR DEL TALLER CARLOS LEDUC DE LA FACULTAD DE ARQUITECTURA.
2007 Guidelines for the Management of Arterial Hypertension (2007)

Udgivelsesdato: 2007-Jun
Antibody Binding Site Mapping of SARS-CoV Spike Protein Receptor-Binding Domain by a Combination of Yeast Surface Display and Phage Peptide Library Screening (2009)

The receptor-binding domain (RBD) of severe acute respiratory syndrome coronavirus (SARS-CoV) spike (S) protein plays an important role in viral infection, and is a potential major neutralizing determinant. In this study, three hybridoma cell lines secreting specific monoclonal antibodies against the RBD of the S protein were generated and their exact binding sites were identified. Using yeast surface display, the binding sites of these antibodies were defined to two linear regions on the RBD: S(337-360) and S(380-399). Using these monoclonal antibodies in phage peptide library screening identified 10 distinct mimotopes 12 amino acids in length. Sequence comparison between native epitopes and these mimotopes further confirmed the binding sites, and revealed key amino acid residues involved in antibody binding. None of these antibodies could neutralize the murine leukemia virus pseudotyped expressing the SARS-CoV spike protein (MLV/SARS-CoV). However, these mAbs could be useful in the diagnosis of SARS-CoV due to their exclusive reactivity with SARS-CoV. Furthermore, this study established a feasible platform for epitope mapping. Yeast surface display combined with phage peptide library screening provides a convenient strategy for the identification of epitope peptides from certain antigenic proteins.
Novel therapeutics for metastatic renal cell carcinoma (2009)

The treatment of metastatic renal cell carcinoma (RCC) has changed dramatically during the past few years. Sunitinib malate, sorafenib tosylate, bevacizumab with interferon alpha, temsirolimus, and everolimus have improved clinical outcomes in randomized phase 3 trials by inhibiting the vascular endothelial growth factor and related pathways. Combinations and sequences of these agents are being evaluated. Other novel agents are in clinical development, some of which target novel pathways not yet exploited as therapy for RCC. Recently reported and ongoing clinical trials will help further define the role of these agents as therapy for metastatic RCC.
Evidence for peroxidative damage by nitric oxide in experimental chronic cerebral vasospasm (1996)

Recent data has suggested a role for the nitric oxide metabolite peroxynitrite in peroxidative injury to endothelium associated with atherosclerosis. The present experiments were designed to elucidate whether such a mechanism might be involved in the morphological changes observed during chronic vasospasm after subarachnoid hemorrhage. For this purpose, chronic vasospasm was induced in male Wistar rats by an injection of autologous blood (100 microliters) in the cisterna magna followed by a second injection 24 hours later. Vasospasm was verified by pressure controlled internal carotid angiography after retrograde cannulation of the external carotid artery 7 days after the second injection. Animals were then perfusion fixed and the brains removed for immunohistochemical assessment of nitrotyrosine, the peroxidation product of peroxynitrite with tyrosine contained in tissue proteins. Staining for nitrotyrosine was quantified by microscopy in 40 microns coronal floating sections. The brains of rats with angiographic vasospasm revealed nitrotyrosine predominantly located with a perivascular distribution and in the pia. We conclude that peroxidation of membrane proteins by the nitric oxide metabolite peroxynitrite may contribute to the morphological damage evident in chronic vasospasm.
Assessment of Long-Term Nipple Projection: A Comparison of Three Techniques (2002)

Nipple-areola reconstruction represents the final stage of breast reconstruction, whereby a reconstructed breast mound is transformed into a breast facsimile that more closely resembles the original breast. Although numerous nipple reconstruction techniques are available, all have been plagued by eventual loss of long-term projection. In this report, the authors present a comparative assessment of nipple and areola projection after reconstruction using either a bell flap, a modified star flap, or a skate flap and full-thickness skin graft for areola reconstruction. The specific technique for nipple-areola reconstruction following breast reconstruction was selected on the basis of the projection of the contralateral nipple and whether or not the opposite areola showed projection. Patients with 5 mm or less of opposite nipple projection were treated with either the bell flap or the modified star flap. In patients where the areola complex exhibited significant projection, a bell flap was chosen over the modified star flap. In those patients with greater than 5-mm nipple projection, reconstruction with a skate flap and full-thickness skin graft was performed. Maintenance of nipple projection in each of these groups was then carefully assessed over a 1-year period of follow-up using caliper measurements of nipple and areola projection obtained at 3-month intervals. The best long-term nipple projection was obtained and maintained by the skate and star techniques. The major decrease in projection of the reconstructed nipple occurred during the first 3 months. After 6 months, the projection was stable. The loss of both nipple and areola projection when using the bell flap was so remarkable that the authors would discourage the use of this procedure in virtually all patients.
Inter- and intrapatient variability in etoposide kinetics with oral and intravenous drug administration. (1999)

The objective of this study was to accurately determine the within- and between-patient variability in etoposide pharmacokinetics for i.v. and p.o. administered drug. Inter-and intrapatient variability in systemic etoposide exposure was measured following i.v. and p.o. drug administration using stable isotope dilution methodology. Seven patients received 50 mg of etoposide by both p.o. and i.v. routes of administration on three separate occasions 1 month apart. Etoposide plasma concentrations following p.o. and i.v. drug administration were quantitated by liquid chromatography-mass spectrometry for each route of administration. The area under the plasma etoposide concentration versus time curve, plasma etoposide clearance, and etoposide plasma half-life were calculated for each dose of drug. Kinetic measurements following i.v. and p.o. drug administration were compared. The within-patient variation in the areas under the plasma etoposide concentration versus time curves following i.v. drug administration was minimal [coefficient of variation (CV) = 9.3%]. Within-patient variability was increased 2.4-fold with oral drug administration (intrapatient CV = 22.2%). Between-patient variability was roughly three times as great as within-patient variability (interpatient i.v. CV = 28.4%; interpatient p.o. CV = 58.3%). Mean etoposide bioavailability at a dose of 50 mg was 64.6%, again with greater interpatient than intrapatient variability (34.8 versus 22.6%). Greater variation in drug toxicity is expected with p.o. compared with i.v. etoposide use. Administration of repeated doses of etoposide to the same patient should produce less variation in toxicity than between-patient dosing.
<p>Dual GIP–GLP1-Receptor Agonists In The Treatment Of Type 2 Diabetes: A Short Review On Emerging Data And Therapeutic Potential</p> (2019)

The need for efficient and safe therapy to improve such metabolic diseases as obesity and type 2 diabetes mellitus is currently unmet. The development of dual GIPR-GLP1R coagonists that bind to either one or the other receptor (sequence-mixed dual agonists) has emerged as an innovative therapeutic strategy for obesity and type 2 diabetes. Combined activation of both receptors may act synergistically providing additive effects on glucose and body weight in comparison of GLP1 analogues alone. Preclinical studies have confirmed that GIPR-GLP1R coagonists improve several hallmarks of metabolic syndrome, such as obesity, hyperglycemia, and dyslipidemia. These metabolic benefits have been translated from mice to nonhuman primates and humans. Recent clinical trials have shown that coagonists induce significant benefits on body weight, fasting, and postprandial glucose levels, insulin sensitivity, and total cholesterol. Combined GIP- and GLP1R activators have the potential to become a treatment option for patients with type 2 diabetes.
Neuritogenesis induced by vasoactive intestinal peptide, pituitary adenylate cyclase‐activating polypeptide, and peptide histidine methionine in SH‐SY5y cells is associated with regulated expression of cytoskeleton mRNAs and proteins (2003)

Vasoactive intestinal peptide (VIP) and the related peptides pituitary adenylate cyclase-activating polypeptide (PACAP) and peptide histidine methionine (PHM) are known to regulate proliferation and/or differentiation in normal and tumoral cells. In this study, neuritogenesis in human neuroblastoma SH-SY5Y cells cultured in serum-free medium was induced by VIP, PACAP, and PHM. The establishment of this process was followed by the quantification of neurite length and branching and the expression of neurofilament mRNAs, neurofilament proteins, and other cytoskeletal protein markers of neuronal differentiation: neuron-specific MAPs and beta-tubulin III. Neurite length and branching and the expression of most markers tested were increased by VIP and PACAP in a similar, although slightly different, fashion. In contrast, neuritic elongation induced by PHM was correlated with neither an increase in branching or neurofilament mRNAs nor a clear change in the expression of cytoskeleton proteins, with the exception of the stimulation by PHM of doublecortin, a microtubule-associated marker of migrating neuroblasts. These findings are the first evidence from a human neuron-like cell line for 1) a direct regulation of the metabolism of neurofilaments by VIP and PACAP and 2) the induction by PHM of neuritic processes of an apparent immature character.
Additions of difluorocarbene to an enynes system in a steroid molecule (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAdditions of difluorocarbene to an enynes system in a steroid moleculePierre Crabbe, Paul Anderson, and Esperanza VelardeCite this: J. Am. Chem. Soc. 1968, 90, 11, 2998–2999Publication Date (Print):May 1, 1968Publication History Published online1 May 2002Published inissue 1 May 1968https://pubs.acs.org/doi/10.1021/ja01013a069https://doi.org/10.1021/ja01013a069research-articleACS PublicationsRequest reuse permissionsArticle Views54Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Ocular myasthenia: a rare presentation with MuSK antibody and bilateral extraocular muscle atrophy (2007)

Atrophic extraocular muscles are rarely observed1–3 and bilateral extraocular muscle (EOM) atrophy is extremely rare.3 It has been reported in chronic progressive external ophthalmoplegia (CPEO) related to mitochondrial myopathies,4 myotonic dystrophy type 15 and in three other cases of myasthenia gravis (MG).4 This report is an atypical presentation of ocular MG with positive muscle-specific kinase (MuSK) antibodies and bilateral EOM atrophy.

A 49-year-old man presented with a 12-year history of slowly isolated progressive external ophthalmoplegia. His medical history was unremarkable and he did not take any drugs, smoke or drink alcohol. Examination revealed limitation of gaze in all directions to 3°–5° with bilateral …
Poincaré Embeddings for Learning Hierarchical Representations (2017)

Representation learning has become an invaluable approach for learning from symbolic data such as text and graphs. However, while complex symbolic datasets often exhibit a latent hierarchical structure, state-of-the-art methods typically learn embeddings in Euclidean vector spaces, which do not account for this property. For this purpose, we introduce a new approach for learning hierarchical representations of symbolic data by embedding them into hyperbolic space -- or more precisely into an n-dimensional Poincaré ball. Due to the underlying hyperbolic geometry, this allows us to learn parsimonious representations of symbolic data by simultaneously capturing hierarchy and similarity. We introduce an efficient algorithm to learn the embeddings based on Riemannian optimization and show experimentally that Poincaré embeddings outperform Euclidean embeddings significantly on data with latent hierarchies, both in terms of representation capacity and in terms of generalization ability.
DNA sequence determinants for binding of the Escherichia coli catabolite gene activator protein. (1992)

The consensus DNA site for binding of the Escherichia coli catabolite gene activator protein (CAP) is 22 base pairs in length and is 2-fold symmetric: 5'-AAATGTGATCTAGATCACATTT-3'. Positions 4 to 8 of each half of the consensus DNA half-site are the most strongly conserved. In this report, we analyze the effects of substitution of DNA base pairs at positions 4 to 8, the effects of substitution of thymine by uracil and by 5-methylcytosine at positions 4, 6, and 8, and the effect of dam methylation of the 5'-GATC-3' sequence at positions 7 to 10. All DNA sites having substitutions of DNA base pairs at positions 4 to 8 exhibit lower affinities for CAP than does the consensus DNA site, consistent with the proposal that the consensus DNA site is the ideal DNA site for CAP. Specificity for T:A at position 4 appears to be determined solely by the thymine 5-methyl group. Specificity for T:A at position 6 and specificity for A:T at position 8 appear to be determined in part, but not solely, by the thymine 5-methyl group. dam methylation has little effect on CAP.DNA complex formation. The thermodynamically defined consensus DNA site spans 28 base pairs. All, or nearly all, DNA determinants required for maximal affinity for CAP and for maximal thermodynamically defined CAP.DNA ion pair formation are contained within a 28-base pair DNA fragment that has the 22-base pair consensus DNA site at its center. The quantitative data in this report provide base-line thermodynamic data required for detailed investigations of amino acid-base pair and amino acid-phosphate contacts in this protein-DNA complex.
Digital electronics meets its match (acoustooptic devices) (1988)

The promise shown by acoustooptic (AO) spectrum analyzers and correlators in field-test prototypes for radar, communications and electronic-warfare surveillance is discussed. The principle of operation of AO devices is explained, and its use for correlation and convolution is examined. Two types of Bragg cell (the basic AO component) are described: surface-acoustic-wave (SAW) and bulk cells. The use of a 2-D AO correlator (i.e. one that moves its output beam over an array of photodetectors rather than a single line) in a spread-spectrum receiver is presented to exemplify the use of AO devices.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>