gebhart/patrepeval huggingface dataset:
Highly Cross-Linked Polyethylene in Cemented THA (2003)

Highly cross-linked polyethylene (PE) has been introduced as an alternative bearing material in total hip arthroplasty (THA) because of high wear resistance in laboratory tests but the clinical experience of this material is limited. We evaluated a highly cross-linked PE (warm irradiated adiabatic melting, absorbed dose, 95 kGy) in a randomized study of cemented THAs. Cups of the same design but made of conventionally gamma irradiated PE (absorbed dose, 25-40 kGy) constituted the control group. Sixty-one hips (30 women, 30 men) with a median age of 55 years (range, 35-70 years) were included. All patients received a Spectron stem with 28-mm CoCr head. Radiostereometric examinations with the patient supine or standing were done at regular intervals. Wear was measured with the patient in the supine position from the first postoperative week, whereas examinations done with the patient standing were initiated 3 months after the operation. Dual x-ray absorptiometry and conventional radiography were used to evaluate the bone mineral density and the radiolucencies around the acetabular component. Fifty-two patients (53 hips; 25 highly cross-linked, 28 control) have been followed up for 2 years. At the 2-year followup, the highly cross-linked cups showed 50% reduction of proximal wear compared with the control group, when the patients were studied standing. When evaluated supine, the difference in proximal wear did not reach significance. The migration of the socket, the relative changes of periprosthetic bone mineral density, and the progression of radiolucencies between the immediately postoperative followup and 2-year followup did not differ. Highly cross-linked PE showed increase resistance to wear. Different mechanical properties of the two types of PE studied did not alter the performance of the cup in terms of fixation, periprosthetic bone loss, and radiographic appearance. However, the followup is short and these results are preliminary.
The Benefits and Risks of n-3 Polyunsaturated Fatty Acids (1998)

There is a growing number of animal models and clinical trials of n-3 polyunsaturated fatty acid (PUFAs) supplementation in disease. Epidemiologic and biochemical studies have suggested beneficial effects of n-3 PUFAs. But also, the use of n-3 PUFAs has some potential toxicological risks that can be circumvented by careless processing, storing, and preserving the PUFAs. The use of n-3 PUFAs is safe if appropriate preparations and dosages are selected. Much research is needed to clarify their use under different disease conditions. The newly established clinical and nutritional facts on n-3 PUFAs will induce industry to develop food products based on this knowledge.
Contributors, Nov. 1971 (1971)

Presents a biographical entry for each author and co-author included in this issue of the publication.
On the nature of global classification (1992)

Molecular sequencing technology has brought biology into the era of global (universal) classification. Methodologically and philosophically, global classification differs significantly from traditional, local classification. The need for uniformity requires that higher level taxa be defined on the molecular level in terms of universally homologous functions. A global classification should reflect both principal dimensions of the evolutionary process: genealogical relationship and quality and extent of divergence within a group. The ultimate purpose of a global classification is not simply information storage and retrieval; such a system should also function as an heuristic representation of the evolutionary paradigm that exerts a directing influence on the course of biology. The global system envisioned allows paraphyletic taxa. To retain maximal phylogenetic information in these cases, minor notational amendments in existing taxonomic conventions should be adopted.
Study of Robust and Intelligent Surveillance in Visible and Multi-modal Framework (2007)

This paper gives a review of current state of the art in the development of robust and intelligent surveillance systems, going beyond traditional vision based framework to more advanced multi-modal framework. The goal of automated surveillance system is to assist the human operator in scene analysis and event classification by automatically detecting the objects and analyzing their behavior using computer vision, pattern recognition and signal processing techniques. This review addresses several advancements made in these fields while bringing out the fact that realizing a practical end to end surveillance system still remains a difficult task due to several challenges faced in a real world scenario. With the advancement in sensor and computing technology, it is now economically and technically feasible to adopt multi-camera and multi-modal framework to meet the need of efficient surveillance system in wide range of security applications like security guard for communities and important buildings, traffic surveillance in cities and military applications. Therefore our review includes significant discussion on multi-modal data fusion approach for robust operation. Finally we conclude with discussion on possible future research directions. Povzetek: Opisane so moderne robustne metode inteligentnega nadzora. 1
Signet ring cell cancer: Harbinger of doom? (2012)

10 Background: Signet ring cell cancer (SRC) is associated with worse prognosis. However, studies in Asia have questioned this idea. Our aim is to determine differences in presentation and outcomes between SRC and gastric adenocarcinoma (AC) to establish if SRC conveys worse prognosis in the U.S. Methods: NCI SEER was used to analyze differences in presentation and outcomes of SRC and AC from 2004−2007. Results: 10,886 gastric cancers included 2,872 SRC and 8,014 AC. SRC presented younger (62.0 vs 68.9 years, p<0.001) and less in males (53.7 vs 68.0%, p<0.001). SRC were more likely Asian (16.5 vs 13.5%) or Hispanic (23.3 vs 14.9%) and less Black (10.7 vs 11.5%) or White (71.8 vs 74.1%); p<0.001. SRC was more likely to be T-3 or T-4 (46.0 vs 33.8%), have nodal spread (72.5 vs 62.0%), and metastases (29.0 vs 24.1%); p<0.001. SRC was more likely lower stomach (30.6 vs 24.6%) or body (30.8 vs 21.6%) and less upper stomach (24.7 vs 46.9%); p<0.001. SRC more often overlapped regions (13.9 vs 6.9%, p<0.001). SRC was associated with mortality (HR 1.07, CI 1.01−1.14, p=0.017) and decreased median survival (12.0 vs. 13.0 months, p=0.034). Multivariate analysis stratified by AJCC stage and radiation found SRC was not independently associated with mortality (HR 1.04, CI 0.98−1.11, p=0.195). Mortality was associated with age (HR 1.01, CI 1.01−1.01, p=0.001), Black race (HR 1.11, CI 1.02−1.21, p=0.013), and tumor grade ( table ). Survival was associated with Asian race (HR 0.88, CI 0.81−0.95, p=0.001) and surgery (HR 0.21, CI 0.19−0.22, p=0.001). Conclusions: In the U.S., SRC differs from AC in presentation with younger age, less male predominance, greater tumor extent, metastases, and Asian or Hispanic ethnicity. Survival for SRC is associated with Asian race and surgical resection. Overall, SRC survival is less than AC. However, adjusted for stage at presentation, SRC does not portend a worse prognosis. [Table: see text]
Angiotensin II reduces infarct size and has no effect on post‐ischaemic contractile dysfunction in isolated rat hearts (2001)

1. In order to test the hypothesis that angiotensin II exacerbates myocardial ischaemia-reperfusion (IR) injury, we examined the effects of graded angiotension II concentrations of angiotensin II on IR injury in both working and non-working (Langendorff) isolated rat hearts. 2. Non-working hearts were subjected to 30 min aerobic perfusion (baseline) then 25 min of global, no-flow ischaemia followed by 30 min of reperfusion either in the absence (control, n=7) or presence of 1 (n=6) or 10 nM (n=5) angiotensin II). Recoveries of LV developed pressure and coronary flow after 30 min reperfusion in control hearts (58+/-9 and 40+/-8% of baseline levels, respectively) were no different from hearts treated with 1 or 10 nM angiotensin II. Infarct size (determined at the end of reperfusion by triphenyltetrazolium chloride staining) was reduced by angiotensin II in a concentration-dependent manner (from a control value of 27+/-3 to 18+/-4% and 9+/-3% of the LV, respectively). 3. Working hearts were subjected to 50 min pre-ischaemic (pre-I) aerobic perfusion then 30 min of global, no-flow ischaemia followed by 30 min of reperfusion either in the absence (control, n=14) or presence of 1 (n=8), 10 (n=7) or 100 nM (n=7) angiotensin II). In controls, post-ischaemic (post-I) left ventricular (LV) work and efficiency of oxygen consumption were depressed (43+/-9 and 42+/-10% of pre-I levels, respectively). The presence of angiotensin II throughout IR had no effect on LV work compared with control. 4. Thus, angiotensin II reduces infarct size in a concentration-dependent manner but has no effect on contractile stunning associated with IR in isolated rat hearts.
Sex and Pessimism in King Lear (1960)

Sex and Pessimism in King Lear Get access Robert H. West Robert H. West University of Georgia Search for other works by this author on: Oxford Academic Google Scholar Shakespeare Quarterly, Volume 11, Issue 1, Winter 1960, Pages 55–60, https://doi.org/10.2307/2867431 Published: 01 January 1960
Hydrophobicity of methylated DNA as a possible mechanism for gene silencing (2012)

AFM images show that chromatin reconstituted on methylated DNA (meDNA) is compacted when imaged under water. Chromatin reconstituted on unmethylated DNA is less compacted and less sensitive to hydration. These differences must reflect changes in the physical properties of DNA on methylation, but prior studies have not revealed large differences between methylated and unmethylated DNA. Quasi-elastic light scattering studies of solutions of methylated and unmethylated DNA support this view. In contrast, AFM images of molecules at a water/solid interface yield a persistence length that nearly doubles (to 92.5 ± 4 nm) when 9% of the total DNA is methylated. This increase in persistence length is accompanied by a decrease in contour length, suggesting that a significant fraction of the meDNA changes into the stiffer A form as the more hydrophobic meDNA is dehydrated at the interface. This suggests a simple mechanism for gene silencing as the stiffer meDNA is more difficult to remove from nucleosomes.
Measurement-Based Admission Control in Integrated-Services Networks (1998)

To satisfy the quality of service requirements of real-time multimedia applications, networks must employ resource reservation and admission control. In this paper, we describe a new Measurement-Based Admission Control (MBAC) algorithm that uses empirical traffic envelopes of the aggregate traffic flow to allocate network resources. Our framework of traffic envelopes provides a robust and accurate characterization of the aggregate flow, capturing the extent to which flows statistically multiplex as well as the temporal correlation structure of the aggregate flow. In estimating applications&apos; future performance, we introduce the notion of a schedulability confidence level which describes the uncertainty of the measurement-based &quot;prediction&quot;, based on which we devise techniques to accurately estimate packet loss probability for a buffered multiplexer servicing heterogeneous and bursty traffic flows.
Shedding light on the structure of internet video quality problems in the wild (2013)

The key role that video quality plays in impacting user engagement, and consequently providers' revenues, has motivated recent efforts in improving the quality of Internet video. This includes work on adaptive bitrate selection, multi-CDN optimization, and global control plane architectures. Before we embark on deploying these designs, we need to first understand the nature of video of quality problems to see if this complexity is necessary, and if simpler approaches can yield comparable benefits.
[Studies on the immunohistochemical localization of adhesive factors at the site of implantation in the early pregnancy]. (1990)

We studied the localization of adhesive proteins at the site of implantation in mouse pregnancy (5 days' gestation), and human pregnancy (5-8 weeks' gestation) and in human endometrial culture cells. Immunohistochemical staining of adhesive protein such as fibronectin (FN), laminin, type IV collagen (CIV), subunit A of factor XIII (XIIIA), and subunit S of factor XIII (XIIIs) were performed by indirect enzyme immunoassay to investigate their localization. (1) In mouse pregnancy: FN and XIIIs were stained in trophoblastic giant cells, and CIV was stained in the endometrial epithelium. (2) In human pregnancy: (fetal side) CIV was stained diffusely on the surface of syncytiotrophoblast. FN, CIV, and XIIIA were stained in the stroma of the villi. (maternal side) FN, CIV, and XIIIA were stained in the endometrial stroma. (3) In endometrial culture cells: FN and XIIIA were stained strongly in the stromal cells. These findings demonstrated that FN and XIIIA are produced in the endometrial stromal cells, and suggest that FN, CIV, and XIIIA are concerned with the attachment of the embryo to the uterus. Therefore, these adhesive proteins are important factors in maintaining pregnancy.
<i>pha-4,</i> an<i>HNF-3</i> homolog, specifies pharyngeal organ identity in<i>Caenorhabditis elegans</i> (1998)

To build complex organs, embryos have evolved mechanisms that integrate the development of cells unrelated to one another by cell type or ancestry. Here we show that the pha-4 locus establishes organ identity for the Caenorhabditis elegans pharynx. In pha-4 mutants, pharyngeal cells are transformed into ectoderm. Conversely, ectopic pha-4 expression produces excess pharyngeal cells. pha-4 encodes an HNF-3 homolog selectively expressed in the nascent digestive tract, including all pharynx precursors at the time they are restricted to a pharyngeal fate. We suggest that pha-4 is a key component of a transcription-based mechanism to endow cells with pharyngeal organ identity.
Generalizing Hindley-Milner Type Inference Algorithms (2002)

Type inferencing according to the standard algorithms often yields uninformative error messages. Many times, this is a consequence of a bias inherent in the algorithms. The method developed here is to first collect constraints from the program, and to solve these afterwards, possibly under the influence of a heuristic. We show the soundness and completeness of our algorithm. The algorithms turn out to be deterministic instances of our method, giving the correctness for with respect to the Hindley-Milner typing rules for free. We also show that our algorithm is more flexible, because it naturally allows the generation of multiple messages.
The chromosome ends of <i>Saccharomyces cerevisiae</i> (1995)

Yeast chromosome ends are similar in structure and function to chromosome ends in most, if not all, eukaryotic organisms. There is a G-rich terminal repeat at the ends which is maintained by telomerase. In addition to the classical functions of protecting the end from degradation and end-to-end fusions, and completing replication, yeast telomeres have several interesting properties including: non-nucleosomal chromatin structure; transcriptional position effect variegation for genes with adjacent telomeres; nuclear peripheral localization; apparent physical clustering; non-random recombinational interactions. A number of genes have been identified that are involved in modifying one or more of these properties. These include genes involved in general DNA metabolism, chromatin structure and telomere maintenance. Adjacent to the terminal repeat is a mosaic of middle repetitive elements that exhibit a great deal of polymorphism both between individual strains and among different chromosome ends. Much of the sequence redundancy in the yeast genome is found in the sub-telomeric regions (within the last 25 kb of each end). The sub-telomeric regions are generally low in gene density, low in transcription, low in recombination, and they are late replicating. The only element which appears to be shared by all chromosome ends is part of the previously defined X element containing an ARS consensus. Most of the 'core' X elements also contain an Abf1p binding site and a URS1-like element, which may have consequences for the chromatin structure, nuclear architecture and transcription of native telomeres. Possible functions of sub-telomeric repeats include: fillers for increasing chromosome size to some minimum threshold level necessary for chromosome stability; barrier against transcriptional silencing; a suitable region for adaptive amplification of genes; secondary mechanism of telomere maintenance via recombination when telomerase activity is absent.
Financial distress - the responsibility of the professional accountant (SA) : : accounting technical (2016)

Section 128(f) of the Companies Act of 2008 defines financial distress of the business as being reasonably:
(i) Unlikely to meet its debt obligations when they are due within the immediately ensuing six months, and
(ii) Likely to become insolvent within the immediately ensuing six months. The Professional Accountant (SA) has a responsibility to assess the going concern (in terms of the accounting standards) as well as performing the liquidity and solvency test (in terms of the Companies Act) of the business when compiling the financial statements. The question that needs to be addressed is What are the warnings signs that indicate that a business may be in or heading towards financial distress?
Power generating by high pulse mechanical stimulation of magnetic coupled NdFeB and Terfenol-D (2010)

Rising requirements for a new constructions, devices and machines force engineers to monitor them all day long. An attractive solution seems to be applications of wireless sensors. However, there is a barrier limiting their application, which is the need to supply them with an electrical power over extended period of time without using additional wiring or batteries. The potential solution of this problem seems to be an energy harvesting. Most methods of obtaining the energy from the external sources e.g. vibrations, is to use piezoelectric materials. However, the amount of energy generated by piezoelectric materials is smaller than most electronic devices need. Therefore a new method for generating a pulse of energy and conditioning for other loads devices must be developed. This paper proposes a new energy harvesting device based on magnetostrictive material. In the course of the experiments with using Terfenol-D rods as actuators and sensors it has been observed interesting phenomenon. Mechanical impact (e.g.energy between 1J and 10J in infinite time) to magnetic core based on Terfenol-D rod (diameter 5mm, length 10 mm), NdFeB permanent magnets and coil allowed get electric power signal enough to supply device of 100 Ohm load on their active state (typical low power controller). In comparison to the same magnetic circuit built with other typical ferromagnetic materials e.g. Armco iron, showed effect 10 times lower or none. Tests and experiments showed the important role of coupling Terfenol-D and NdFeB permanent magnets, their configuration and variable coil parameters determined this effect. In regard to the results the authors proposed the construction of a new impulse harvesting method based on Terfenol-D material for low impedance load.
The Anopheles (Anopheles) Crucians Subgroup in the United States (Diptera: Culicidae) (1976)

Abstract : Anopheles (Anopheles) bradleyi King, An. (Ano.) crucians Wiedemann and An. (Ano.) georgianus King are taxonomically redefined by morphology, ethology and distribution, and established as the crucians subgroup of the An. (Ano.) punctipennis (Say) species group. This study involved the examination of over 1,800 specimens and the preparation of 15 full-page illustrations. Species descriptions include sections on: type-data, synonymy, descriptions of female, male, pupa, and larva, distribution, taxonomic discussion, bionomics and medical importance. Keys for the crucians subgroup are presented for male genitalia, pupae and 4th stage larvae. Additional keys are presented, in an appendix, to separate the crucians subgroup from the other southeastern United States anophelines. The 1st through 4th stage larvae of bradleyi and crucians, the 4th stage larva of georgianus and the pupae of bradleyi and georgianus are completely illustrated for the first time. Tables with the ranges of setal branching are included for the 4th stage larvae and pupae of each species.
<i>ID</i> genes mediate tumor reinitiation during breast cancer lung metastasis (2007)

The establishment of distant metastases depends on the capacity of small numbers of cancer cells to regenerate a tumor after entering a target tissue. The mechanisms that confer this capacity remain to be defined. Here we identify a role for the transcriptional inhibitors of differentiation Id1 and Id3 as selective mediators of lung metastatic colonization in the triple negative [TN, i.e., lacking expression of estrogen receptor and progesterone receptor, and lacking Her2 (human epidermal growth factor receptor 2) amplification] subgroup of human breast cancer. Although broad expression of Id1 has recently been documented in tumors of the rare metaplastic subtype, here we report that rare Id1-expressing cells are also present in the more common TN subset of human breast tumors but not in other subtypes. We also provide evidence that Id1 expression is enriched in clinically obtained hormone receptor negative lung metastases. Functional studies demonstrate that Id1 and its closely related family member Id3 are required for tumor initiating functions, both in the context of primary tumor formation and during metastatic colonization of the lung microenvironment. In vivo characterization of lung metastatic progression reveals that Id1 and Id3 facilitate sustained proliferation during the early stages of metastatic colonization, subsequent to extravasation into the lung parenchyma. These results shed light on the proliferative mechanisms that initiate metastatic colonization, and they implicate Id1 and Id3 as mediators of this malignant function in the TN subgroup of breast cancers.
Auto-master-slave control technique of parallel inverters in distributed AC power systems and UPS (2004)

This work presents a new control scheme: auto-master-slave control technique of parallel connected SPWM inverters. The control scheme ensures a fast dynamic response and precise load current sharing capability. Based on auto-master-slave control technique, the control circuitry employs the real power share bus and reactive power share bus interconnecting all the paralleled inverters. With the power share buses and the power deviation controllers, the paralleled inverter with highest output power becomes the master inverter; other inverters become slave inverters. Master inverter drive the power bus, and the power deviations in slave inverter module are calculated by the power sharing controller. Hereafter, the inverters compensate for the frequency and amplitude of output voltage, and then the unbalance power was eliminated. An experiment system was built to verify this control scheme, and the results indicate the precise power balance performance for parallel operation.
Accumulation of Hemoglobin‐Associated Acetaldehyde With Habitual Alcohol Drinking in the Atypical <i>ALDH</i> Genotype (2000)

We demonstrated that HbAA levels accumulate with habitual alcohol drinking in the atypical ALDH2 genotype. HbAA was shown to be a good biomarker for increased internal exposure levels to acetaldehyde.