gebhart/patrepeval huggingface dataset:
Kinetic and Thermodynamic Analysis of Thermal Unfolding of Recombinant Erythropoietin (2001)

Thermal stress was used to assess the stability of recombinant human erythropoietin (EPO) derived from Chinese hamster ovary cells. In 20 mm phosphate at pH 7.0, this protein had a highly reversible thermal unfolding as observed by far UV circular dichroism (CD) and native gel analysis, with no indication of protein aggregation. It had a relatively low melting temperature at 53 degrees C. Assuming a two-state transition, the observed reversibility permits thermodynamic analysis of the unfolding of EPO, which shows that the free energy of unfolding at 25 degrees C is only 6-7 kcal/mol. Upon heating to 79 degrees C over 30 min, however, this protein does undergo aggregation as assessed by native gel. In 20 mm phosphate and citrate at pH 7.0, the results are similar, i.e., EPO suffered a substantial aggregation, while it showed little aggregation in 20 mm Tris or histidine at pH 7.0 and 20 mm glycine at pH 6.3 under identical heat treatment.
Autonomic load-testing framework (2011)

In this paper, we present a method for performance testing of transactional systems. The methods models the system under test, finds the software and hardware bottlenecks and generate the workloads that saturate them. The framework is autonomic, the model and workloads are determined during the performance test execution by measuring the system performance, fitting a performance model and by analytically computing the number and mix of users that will saturate the bottlenecks.
Data-aided noncoherent demodulation of DPSK (1995)

Considers noncoherent demodulation of DPSK when the receiver has partial knowledge of the information being transmitted. This partial knowledge represents preamble symbols, pilot symbols, or past decisions when operating in a decision-feedback mode. The maximum likelihood (ML) noncoherent receiver for this case is derived. It is shown that known demodulation schemes such as multi-symbol differentially coherent receivers and decision-feedback differential receivers can be considered as special cases of this data-aided noncoherent DPSK demodulator. A simple recursive structure for this receiver is introduced and its performance analyzed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Wang Resin Bound Addition Reactions Under Microwave Irradiation (1999)

Abstract The addition reaction process of Wang resin bound amines with isocyanates was monitored directly using a FTIR method. It showed that the reaction process was greatly enhanced under microwave irradiation.
<i>In vivo </i>Characteristics of Temperature-Sensitive Host Range Mutants of Herpes Simplex Virus Type 2 (1975)

The in vivo properties of four host range temperature-sensitive (ts) mutants of herpes simplex virus type 2 (HSV-2) were correlated with known in vitro characteristics. Mutants and parental virus were inoculated into newborn and weanling mice and weanling hamsters by intracranial and subcutaneous routes, and into weanling rabbits by corneal scarification. In all cases the pattern of attenuation of mutants in vivo correlated with their stability in vitro at 39 degrees. The most attenuated mutant (mutant 69) was also the most consistent in its inability to induce cytopathic effects (CPE) in vitro or to replicate under nonpermissive conditions. Conversely, the most virulent mutant (mutant 41) was the least stable under nonpermissive conditions.
Beyond quantum jumps: Blinking nanoscale light emitters (2009)

On the nanoscale, almost all light sources blink. Surprisingly, such blinking occurs on time scales much larger than predicted by quantum mechanics and has statistics governed by nonergodicity.
Processable heat‐resistant polymers. VII. Synthesis and characterization of polyamideimide from <i>N</i>‐(<i>p</i>‐carboxyphenyl) trimellitimide and <i>p</i>,<i>p</i>′‐di(aminocyclohexyl) methane (1982)

Abstract Polyamideimides were prepared either directly from N‐(p ‐carboxyphenyl)trimellitimide and p , p ′‐di(aminocyclohexy)methane (PACM‐20) by low temperature (<5°C) polycondensation in presence of thionyl chloride or by reacting the diacid chloride of N ‐( p ‐carboxyphenyl)trimellitimide and PACM‐20 at 30–70°C. The polymers were characterized by nitrogen analysis and IR spectra. The polymers are soluble in highly polar solvents such as DMF, DMAC, NMP, and m ‐cresol. The solubility parameter was calculated from the Small's group contribution, which agrees well with the experimental value. The solution viscosity of the polymer is fairly stable against ageing. The T g of the polymer calculated from the DTA curve is 270°C or even higher. Thermal analyses indicated that the polymer is fairly stable and only 5–6% weight loss occurs up to 350°C or 380°C. Dielectric constant, dielectric loss, and electrical conductivity of the polymer were also studied.
CASA: Contention-Aware Scratchpad Memory Allocation for Online Hybrid On-Chip Memory Management (2014)

Scratchpad memory (SPM) has been increasingly used in embedded systems due to its higher efficiency in terms of energy and area compared to that of ordinary cache. A hybrid on-chip memory architecture that combines SPM with a mini-cache has been proposed. One key issue for hybrid on-chip memory architectures is to reduce the number of off-chip memory accesses and energy consumption. Existing methods achieve this by moving the most frequently accessed data into SPM. However, these methods may be ineffective because the main source of off-chip memory accesses may not be the most frequently accessed data. Instead, most off-chip memory accesses are caused by cache misses, so reducing the latter will reduce the former. Cache misses are mainly caused by data contending for cache lines. Therefore, this paper proposes a contention-aware SPM allocation method for hybrid on-chip management. The number of cache misses for a page is used as a metric to determine whether a page should be moved to SPM. When the number of misses for a page exceeds a threshold, the page is moved to SPM, reducing cache contention. Experimental results show that the proposed method can reduce the energy delay product by 35% to 53% compared to a cache-only on-chip memory architecture and 19% to 31% compared to an existing hybrid on-chip memory architecture.
Full Attitude Control of a VTOL tailsitter UAV (2016)

This paper addresses the challenges of the design, development and control of a new convertible VTOL tailsitter unmanned aerial vehicle that combines the advantages of both fixed wing and rotary wing systems. Wind tunnel measurements are used to get an understanding of the control allocation and to model the static forces and moments acting on the system. Based on the derived model, a novel controller that operates in SO(3) and handles the dynamics of the vehicle at any attitude configuration, including the rotorcraft and fixed-wing regimes as well as their transitions, is presented. This unified controller allows the autonomous transition of the system without discontinuities of switching, as well as its overall high performance flight control. The capabilities and flying qualities of the platform and the controller are demonstrated and evaluated by means of extensive experimental studies.
The evolution of enterprise resource planning systems as an IT innovation: A performative perspective (2013)

1
Hypoxia-induced activation in small isolated pulmonary arteries from the cat (1985)

Effects of hypoxia on force development and membrane potential were studied in isolated small (less than 300 microns diam) and large (greater than 500 microns diam) pulmonary arteries from cats. There was a consistent and reproducible hypoxic constrictor response in small pulmonary arteries that began at PO2 values between 350 and 300 Torr and reached a maximum at PO2 between 50 and 30 Torr. In the small artery smooth muscle cell the membrane potential, which was -51 +/- 1.4 mV at a PO2 of 400 Torr, was depolarized to -37 +/- 2 mV at a PO2 of 50 Torr. In contrast, larger arteries did not exhibit significant hypoxic constriction or depolarization upon exposure to low PO2. Constriction in small arteries was not blocked by phentolamine. Treatment with a low dose of indomethacin (10(-9) M) augmented the response; however, a larger dose of indomethacin (10(-3) M) blocked the constriction to hypoxia but not to 30 mM KCl. Depolarization during hypoxia was not blocked by ouabain. Results of this study suggest that the hypoxic response of these isolated small pulmonary vessels may be like that seen in the intact lung. Furthermore, these data suggest that hypoxic vasoconstriction may be mediated by electrical events occurring at the pulmonary arterial muscle cell membrane either directly or via mediators released from the vessel wall.
Assessment of Research Needs for Advanced Fuel Cells (1985)

The DOE Advanced Fuel Cell Working Group (AFCWG) was formed and asked to perform a scientific evaluation of the current status of fuel cells, with emphasis on identification of long-range research that may have a significant impact on the practical utilization of fuel cells in a variety of applications. The AFCWG held six meetings at locations throughout the country where fuel cell research and development are in progress, for presentations by experts on the status of fuel cell research and development efforts, as well as for inputs on research needs. Subsequent discussions by the AFCWG have resulted in the identification of priority research areas that should be explored over the long term in order to advance the design and performance of fuel cells of all types. Surveys describing the salient features of individual fuel cell types are presented in Chapters 2 to 6 and include elaborations of long-term research needs relating to the expeditious introduction of improved fuel cells. The Introduction and the Summary (Chapter 1) were prepared by AFCWG. They were repeatedly revised in response to comments and criticism. The present version represents the closest approach to a consensus that we were able to reach, which should not be interpreted to mean that each member of AFCWG endorses every statement and every unexpressed deletion. The Introduction and Summary always represent a majority view and, occasionally, a unanimous judgment. Chapters 2 to 6 provide background information and carry the names of identified authors. The identified authors of Chapters 2 to 6, rather than AFCWG as a whole, bear full responsibility for the scientific and technical contents of these chapters.
Containing Zika while we wait for a vaccine (2017)

Though no longer considered an emergency by the World Health Organization, Zika virus has reached over 70 countries and continues to spread. 1 As long as each infected person infects, on average, at least one other person, the pandemic will grow. In highly affected areas, widespread infection and herd immunity could ultimately stall transmission but only after devastating consequences for new babies. 2 4] Other approaches are needed to stem transmission.
Synthesis of ordered Si nanowire arrays in porous anodic aluminum oxide templates (2001)

Highly ordered poly crystalline Si nanowire arrays were synthesized in porous anodic aluminum oxide (AAO) templates by the chemical vapor deposition (CVD) method. The morphological structure, the crystal character of Si nanowire arrays and the individual nanowire were analyzed by the transmission electron microscopy (TEM), scanning electron microscopy (SEM), atom force microscopy (AFM) and the X-ray diffraction spectrum (XRD), respectively. It is shown that most fabricated silicon nanowires (SiNWs) tend to be assembled parallelly in bundles and constructed with highly orientated arrays. This method provides a simple and low cost fabricating craftwork and the diameters and lengths of SiNWs can be controlled, the large area Si nanowire arrays can be achieved easily under such a way. The curling and twisting SiNWs are fewer than those by other synthesis methods.
A multicenter, open-label study to assess the safety and efficacy of ciclopirox topical suspension 0.77% in the treatment of diaper dermatitis due to Candida albicans. (2005)

Ciclopirox is a broad-spectrum antifungal, antibacterial, and anti-inflammatory agent. This open-label study investigated the safety and efficacy of ciclopirox topical suspension 0.77% in the treatment of diaper dermatitis due to Candida albicans (C. albicans). Forty-four male and female subjects aged 6 to 29 months were included in the study. Study medication was applied topically to the affected diaper area twice daily for 1 week. Subjects were clinically evaluated at baseline and days 3, 7, and 14 (7 days post-treatment). Safety and efficacy variables included adverse events, mycological culture studies, KOH tests, Severity Scores, and Global Evaluation of Clinical Response. All adverse events were mild to moderate and considered not related to the study medication. Treatment provided statistically significant improvement (P < .05) for both the rate of mycological cure and reduction of Severity Score at each time point compared with baseline. Ciclopirox was safe and effective in the treatment of diaper dermatitis due to C. albicans.
Online Video SEEDS for Temporal Window Objectness (2013)

Super pixel and objectness algorithms are broadly used as a pre-processing step to generate support regions and to speed-up further computations. Recently, many algorithms have been extended to video in order to exploit the temporal consistency between frames. However, most methods are computationally too expensive for real-time applications. We introduce an online, real-time video super pixel algorithm based on the recently proposed SEEDS super pixels. A new capability is incorporated which delivers multiple diverse samples (hypotheses) of super pixels in the same image or video sequence. The multiple samples are shown to provide a strong cue to efficiently measure the objectness of image windows, and we introduce the novel concept of objectness in temporal windows. Experiments show that the video super pixels achieve comparable performance to state-of-the-art offline methods while running at 30 fps on a single 2.8 GHz i7 CPU. State-of-the-art performance on objectness is also demonstrated, yet orders of magnitude faster and extended to temporal windows in video.
Analytical aspects of nuclear quadrupole resonance spectrometry (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAnalytical aspects of nuclear quadrupole resonance spectrometryEdward G. BrameCite this: Anal. Chem. 1967, 39, 8, 918–921Publication Date (Print):July 1, 1967Publication History Published online1 May 2002Published inissue 1 July 1967https://pubs.acs.org/doi/10.1021/ac60252a015https://doi.org/10.1021/ac60252a015research-articleACS PublicationsRequest reuse permissionsArticle Views56Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Evaluation of BSPcast Disease Warning System in Reduced Fungicide Use Programs for Management of Brown Spot of Pear (2000)

A forecasting model (BSPcast) developed for prediction of brown spot (Stemphylium vesicarium) of pear was evaluated as an advisory system for reduced fungicide use in disease management programs. Eleven trials were performed during 1995, 1996, and 1997 in five orchards in two different climatic areas in Catalunya (Spain) and Emilia-Romagna (Italy). Values of 3-day cumulative daily infection risk (CR) provided by the model were used to determine risk periods during the growing season of pear and were taken as thresholds to schedule fungicide sprays. The fungicide application programs tested using the model consisted of guided schedules with CR action thresholds of 0.4, 0.5, or 0.6, and fixed sprays following a standard commercial schedule. In nine out of 10 trials, no significant differences were observed in disease incidence on fruit at harvest between the fixed-spray commercial schedule and guided sprays using thresholds of 0.4 or 0.5. The average savings in number of fungicide sprays applied using BSPcast compared with the fixed-spray schedule were 20 to 70% when using fungicides with a 15-day protection period (kresoxim-methyl or procymidone) and ranged from 20 to 50% when using a fungicide with a 7-day protection period (thiram).
A hybrid speech signal based algorithm for pitch marking using finite state machines (2008)

Pitch marking is a major task in speech processing. Thus, an accurate detection of pitch marks (PM) is required. In this paper, we propose a hybrid method for pitch marking that combines outputs of two different speech signal based pitch marking algorithms (PMA). We use a finite state machine (FSM) to represent and combine the pitch marks. The hybrid PMA is implemented in four stages: preprocessing, alignment, selection and postprocessing. In the alignment stage, the preprocessed pitch marks are shifted to a local minimum of the speech signal and the confidence score for every pitch mark is calculated. The confidence scores are used as transition weights for the FSM. The PMA outputs are combined into a single sequence of pitch marks. The more accurate pitch marks with the highest confidence score are chosen in the selection stage. A PM reference database contains 10 minutes speech including manually adjusted PM. The evaluation results indicate that the proposed hybrid method outperforms the single PMAs but also other current state-of-the-art algorithms which have been evaluated on a second reference database containing 44 speakers.
Measurement and Modelling of Scattering From Buildings (2007)

The results of a measurement campaign aimed at determining the far-field diffuse scattering pattern of typical building walls are shown in the paper. Such results are then used to determine and tune simple diffuse scattering models based on the effective roughness approach, to be embedded into ray tracing simulators. It is shown that by adopting an appropriate single-lobe scattering pattern the agreement between simulation and measurement is very good
Surface treatment and characterization: Perspectives to electrophoresis and lab‐on‐chips (2006)

The control and modification of surface state is a major challenge in bioanalytical sciences, and in particular in electrokinetic separation methods, due to the importance of electroosmosis. This topic has gained recently a renewed interest, associated with the development of "lab-on-chips" systems that extend the range of materials in which separation channels are fabricated. The surface science community has developed through the years a large toolbox of characterization tools and surface modification protocols, which is not yet fully exploited in the bioanalytical world. In this paper, we try and present an overview of these tools, in order to stimulate new ideas for improved and more controlled surface treatment strategies for separations in capillaries and microchannels. We briefly describe some physical and chemical aspects of electroosmosis (global and spatially resolved), streaming current, and streaming potential. We also review the main strategies for surface coating, and compare the advantages of physisorption, well-organized thin self-assembled monolayers, or conversely thick polymer "brushes". Examples of existing applications to electrophoresis in microchannel are also given.
Internal Stark Effect Measurement of the Electric Field at the Amino Terminus of an α Helix (1992)

The strengths of electrostatic interactions in biological molecules are difficult to calculate or predict because they occur in complicated, inhomogeneous environments. The electric field at the amino terminus of an alpha helix in water has been determined by measuring the shift in the absorption band for a covalently attached, neutral probe molecule with an electric dipole moment difference between the ground and excited electronic states (an internal Stark effect). The field at the interface between the helix and the solvent is found to be an order of magnitude stronger than expected from the dielectric properties of bulk water. Furthermore, although the total electric dipole moment of the helix increases with length, the electric field at the amino terminus does not.
Preparation and Blood Compatibility of New Silica-Chitosan Hybrid Biomaterials (1998)

The development of new materials containing both organic and inorganic structures is of great interest with respect to achievement of obtaining the special properties, and the solgel process has provided new opportunities for making such materials. In this paper, new silica-chitosan hybrid biomaterials were produced by this technique, using biopolymer chitosan and its heparin-like derivative as the organic species to be incorporated into the silicon alkoxide (TEOS) based network. All the samples made were in form of thin, flexible films with optical clarity. Microphase separated structure was observed in the hybrid surface, with hydrophobic SiO2 and hydrophilic chitosan interleaved. These hybrid materials displayed good blood compatibility in comparison with their single component systems.
Pd/Ge ohmic contacts to <i>n</i>-type GaAs formed by rapid thermal annealing (1994)

Pd/Ge ohmic contact to n-type GaAs is obtained by using the rapid thermal annealing (RTA) method. The best specific contact resistivity of ohmic contacts annealed at 400–500 °C is on the order of 10−6 Ω cm2. Secondary ion mass spectrometry (SIMS) measurement shows that these ohmic contacts are very shallow. Gallium dissociation from GaAs is observed. It is found that there is a correlation between a gallium SIMS signal bump and good ohmic contact behavior. A model is proposed for this phenomenon. This RTA ohmic contact method has been successfully applied to the fabrication of charge injection transistor/negative resistance field-effect transistor devices.
ChemInform Abstract: Synthesis and Irreversible β‐Adrenergic Blockade with a Bromoacetamido Derivative of Betaxolol. (1986)

Abstract Das Bromacctamidobenzyl‐Derivat (V121) des β‐Blockers Betaxolol (VIb) wird auf dem angegebenen Reaktionsweg hergestellt.
A model-based thruster leakage monitor for the Cassini spacecraft (1998)

The Cassini spacecraft uses thrusters to maintain three-axis attitude control and to perform many other functions. If one of the thrusters leaks, the opposing thrusters will be fired excessively to maintain the commanded attitude. Obviously, the draining of hydrazine and the excessive firings of thrusters must be stopped quickly. A set of three model-based leakage detection monitors has been designed and implemented in the flight software to protect Cassini against the occurrence of this unlikely event. Test results indicate that this design can detect thruster leakage quickly and robustly. Once the leak is detected, the on-board fault protection logic will activate remedial actions which include the swapping of thruster branches.