gebhart/patrepeval huggingface dataset:
Laser Phototherapy following HpD Administration in Superficial Neoplastic Lesions (1984)

We report our preliminary clinical experience with hematoporphyrin derivative (HpD) injection and argon or dye laser irradiation for the treatment of 61 surface neoplastic lesions in 7 patients. Forty-three sites were multiple basal cell carcinoma in 5 patients, and the remaining 18 were cutaneous and subcutaneous recurrent breast carcinoma after mastectomy in the thoracic wall. The patients were selected on the basis of the lack of indication for conventional therapeutic modalities. The selection of irradiation procedures and laser source was based on the thickness of the lesion and extension of the disease. The photochemical reaction between HpD injected i.v. at a dose of 3 mg/kg body weight and the laser beam at a dose of 60 to 120 J/cm2 resulted in 75% favorable responses at the treated sites. Optimal therapeutic effects appeared to be critically dependent on total light dose and tumor infiltration patterns. The phototherapeutic technique proved to be effective in selected cases of neoplastic lesions, especially when conventional treatment modalities were poorly indicated or contraindicated.
The GABA<sub>A</sub> Receptor Agonist THIP Ameliorates Specific Behavioral Deficits in the Mouse Model of Fragile X Syndrome (2011)

Hyperactivity, hypersensitivity to auditory stimuli, and exaggerated fear are common behavioral abnormalities observed in individuals with fragile X syndrome (FXS), a neurodevelopmental disorder that is the most common genetic cause of autism. Evidence from studies of the Fmr1 knockout (KO) mouse model of FXS supports the notion that impaired GABAergic transmission in different brain regions such as the amygdala, striatum or cerebral cortex is central to FXS behavioral abnormalities. This suggests that the GABAergic system might be an intriguing target to ameliorate some of the phenotypes in FXS. Our recent work revealed that THIP (gaboxadol), a GABA(A) receptor agonist, can restore principal neuron excitability deficits in the Fmr1 KO amygdala, suggesting that THIP may also restore some of the key behavioral abnormalities in Fmr1 KO mice. Here, we reveal that THIP significantly attenuated hyperactivity in Fmr1 KO mice, and reduced prepulse inhibition in a volume-dependent manner. In contrast, THIP did not reverse the deficits in cued fear or startle response. Thus, this study shows that enhancing GABAergic transmission can correct specific behavioral phenotypes of the Fmr1 KO mouse further supporting that targeting the GABAergic system, and specifically tonic inhibition, might be important for correcting or ameliorating some key behaviors in FXS.
Synthesis of Magnetic Nanoparticles of Fe3O4 and CoFe2O4 and Their Surface Modification by Surfactant Adsorption (2006)

<TEX>$Fe_3O_4$</TEX> and <TEX>$CoFe_2O_4$</TEX> magnetic nanoparticles have been synthesized successfully in aqueous solution and coated with oleic acid. The solid and organic solution of the synthesized nanoparticles was obtained. Self-assembled monolayer films were formed using organic solution of these nanoparticles. The crystal sizes determined by Debye-Scherre equation with XRD data were found close to the particle sizes calculated from TEM images, and this indicates that the synthesized particles are nanocrystalline. Especially, EDS, ED, FT-IR, TGA/DTA and DSC were used to characterize the nanoparticles and the oleic acid adsorption, and it was found that oleic acid molecule on the <TEX>$Fe_3O_4$</TEX> nanoparticle is a bilayer adsorption, while that on <TEX>$CoFe_2O_4$</TEX> nanoparticle is single layer adsorption. The superparamagnetic behavior of the nanoparticles was documented by the hysteresis loop measured at 300 K.
Design rules based on analyses of human error (1983)

By analyzing the classes of errors that people make with systems, it is possible to develop principles of system design that minimize both the occurrence of error and the effects. This paper demonstrates some of these principles through the analysis of one class of errors: slips of action. Slips are defined to be situations in which the user's intention was proper, but the results did not conform to that intention. Many properties of existing systems are conducive to slips; from the classification of these errors, some procedures to minimize the occurrence of slips are developed.
Influence of Wheat Flour Milling Yield on Physicochemical, Microbial, and Antioxidant Properties of Korea Wheat (Triticum aestivum L. var. Jokyoung) (2020)

The physicochemical, microbial, and antioxidant properties of a Korean wheat variety (Jokyoung) were measured according to milling yield (60–90%) by adding fractions from millstreams. As the milling yield increased, the wheat flour showed low quality on physicochemical properties in general. Significant differences in proximate analysis, color, solvent retention capacity, pasting property, and antioxidant activity were observed as the yield increased to maximize the production of wheat flour from wheat kernels. Adding clear flour and shorts did not significantly affect the quality of the wheat flour in comparison with straight flour samples. However, as brans were added to the flour portion, the wheat flour quality parameters decreased significantly in color, solvent retention capacity, and pasting properties. On the other hand, antioxidant properties increased as brans were added. Maximizing wheat flour yield is a key to minimizing the production cost of Korean wheat flour, which is approximately three times more expensive than imported wheat flour. Adding clear flour and a certain portion of shorts did not seem to significantly influence the overall quality of wheat flour from Korean domestic wheat variety.
Light beam switching and modulation using a built-in dielectric channel in LiNbO<sub>3</sub>planar waveguide (1977)

The results of light beam switching and modulation experiments utilizing electrooptic control of the refractive index of a built-in dielectric channel in a Y-cut LiNbO3 planar waveguide are reported. The resulting device is capable of simultaneously providing a combination of desirable characteristics.
Automated regression testing of graphical user interface based applications (2002)

Summary form only given. This paper discusses the requirements of automating regression testing applications with a graphical user interface. In particular, this paper discusses a regression test facility developed for the X Window System. The facility is composed of two parts called the Input Synthesis Extension and the Client Exerciser tool. The Input Synthesis Extension is incorporated into the X Window System server, and allows a test tool to record the user's interaction with an X server and to play back the interaction. It describes the Input Synthesis Extension and explains how it operates in an X server. The Client Exerciser tool assists in test generation by recording the interaction of a tester with one or more X Window System applications. The tester can also capture information in windows for comparison in subsequent test runs. Once an interactive session with screen captures is recorded, the tool can be used to replay the session, performs screen comparisons at the appropriate times. It describes the functionallity of the Client Exerciser tool, and relates some experience in using it.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
An impression-based retrieval system of music collection (2002)

Recently, we have been able to create multimedia contents easily without individual recourse to each medium. Often one needs to select data to match one's impressions from a medium with which one is unfamiliar. We propose a retrieval method for music using "impression" words. The characteristic of the proposed method is the use of the "affective value" of the musical piece based on results of psychological research on music. In order to develop the affective value, we examine the relationship between the affective value and musical structure by applying machine learning. We present the results of this examination and discuss a method for producing affective values.
Treatment options for benign prostatic hyperplasia (2002)

Papers p 1059 

Lower urinary tract symptoms consistent with benign prostatic hyperplasia become increasingly prevalent with age. While rarely life threatening, bothersome irritative urinary symptoms like urgency, frequency, and nocturia, and obstructive ones like a weak stream, hesitancy, intermittency, and incomplete emptying occur in up to 70% of men aged 70 years and older. Community and practice based studies suggest that men can expect slow progression of the symptoms. However, these symptoms can wax and wane without treatment, and rates of acute urinary retention range from 1-2% per year.1 By the age of 80 years, an estimated one in four men will have undergone treatment to relieve symptoms due to benign prostatic hyperplasia that reduce quality of life.2

Treatment options depend, in part, on the severity of symptoms and how bothersome they are. Options include watchful waiting (conservative or lifestyle management), phytotherapies, prescription medications, surgical procedures, and minimally invasive techniques. To help choose between treatments patients and providers rely on evidence from randomised controlled trials and systematic reviews to provide reliable information about efficacy and safety of various treatments.

For many years, transurethral resection of the prostate has been the gold standard treatment for benign prostatic hyperplasia. In 1994, almost 400 000 procedures were performed in the United States at a total cost of $5 billion.3 In the United Kingdom approximately 40 000 resections are carried out annually.4 …
Transcriptome-wide analysis of blood vessels laser captured from human skin and chronic wound-edge tissue (2007)

Chronic wounds represent a substantial public health problem. The development of tools that would enable sophisticated scrutiny of clinical wound tissue material is highly desirable. This work presents evidence enabling rapid specific identification and laser capture of blood vessels from human tissue in a manner which lends itself to successful high-density (U133A) microarray analysis. Such screening of transcriptome followed by real-time PCR and immunohistochemical verification of candidate genes and their corresponding products were performed by using 3 mm biopsies. Of the 18,400 transcripts and variants screened, a focused set of 53 up-regulated and 24 down-regulated genes were noted in wound-derived blood vessels compared with blood vessels from intact human skin. The mean abundance of periostin in wound-site blood vessels was 96-fold higher. Periostin is known to be induced in response to vascular injury and its expression is associated with smooth muscle cell differentiation in vitro and promotes cell migration. Forty-fold higher expression of heparan sulfate 6-O-endosulfatase1 (Sulf1) was noted in wound-site vessels. Sulf1 has been recently recognized to be anti-angiogenic. During embryonic vasculogenesis, CD24 expression is down-regulated in human embryonic stem cells. Wound-site vessels had lower CD24 expression. The findings of this work provide a unique opportunity to appreciate the striking contrast in the transcriptome composition in blood vessels collected from the intact skin and from the wound-edge tissue. Sets of genes with known vascular functions but never connected to wound healing were identified to be differentially expressed in wound-derived blood vessels paving the way for innovative clinically relevant hypotheses.
Metabolism of 5-(p-hydroxyanilino)-1,2,3,4-thiatriazole in rats (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMetabolism of 5-(p-hydroxyanilino)-1,2,3,4-thiatriazole in ratsGeorge J. IkedaCite this: J. Med. Chem. 1973, 16, 10, 1157–1161Publication Date (Print):October 1, 1973Publication History Published online1 May 2002Published inissue 1 October 1973https://pubs.acs.org/doi/10.1021/jm00268a020https://doi.org/10.1021/jm00268a020research-articleACS PublicationsRequest reuse permissionsArticle Views67Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Future requirements of display phosphors from an historical perspective (1996)

Abstract— The development of emissive displays is briefly outlined and the types of phosphors they utilize are enumerated. The history of phosphor invention and development is briefly outlined up until the modern era starting in the 1930s. The first practical phosphors for CRTs and fluorescent lamps are enumerated and then the rapid developments starting after World War II and advancing through the commercial realization of rare‐earth‐based phosphors are presented. The present electronic, emissive display technologies are then presented together with the phosphor properties that they require; namely, cathodoluminescence‐based displays, photoluminescent displays, i.e. , plasma and LCD backlights, and electroluminescent displays. The presently used phosphors for these displays are mentioned and then the properties of these phosphors that need further improvement are outlined. In conclusion, it is pointed out that the understanding of some phosphor properties or types has reached a considerable state of maturity, but the understanding of other phosphor types, e.g. , electroluminescent phosphors, is still quite rudimentary.
Effects of Direct Water Injection on DI Diesel Engine Combustion (2000)

<div class="htmlview paragraph">The effects of in-cylinder water injection on a direct injection (DI) Diesel engine were studied using a computational fluid dynamics (CFD) program based on the Kiva-3v code. The spray model is validated against experimental bomb data with good agreement for vapor penetration as a function of time. It was found that liquid penetration increased approximately 35% with 23% of the fuel volume replaced by water, due mostly to the increase in latent heat of vaporization.</div> <div class="htmlview paragraph">Engine calculations were compared to experimental results and showed very good agreement with pressure, ignition delay and fuel consumption. Trends for emissions were accurately predicted for both 44% and 86% load conditions. Engine simulations showed that the vaporization of liquid water as well as a local increase in specific heat of the gas around the flame resulted in lower Nitrogen Oxide emissions (NOx) and soot formation rates. Using stratified fuel-water injection increases soot at 86% loads due in part to late injection. Because NOx decreased at all loads, the injection timing can be advanced to minimize fuel consumption and soot.</div>
TheProgrammer's Apprentice: Knowledge Based Program Editing (1982)

An initial implementation ofaninteractive programming assistant system called theprogrammer's apprentice (PA) isdescribed. ThePAisdesigned tobemidway between animproved programming methodology andanautomatic programming system. Theintention is that theprogrammer will dothehardparts ofdesign andimplementa- tionwhile thePAwill assist himwherever possible. Oneofthemajor underpinnings ofthePAisarepresentation (called aplan) forprograms whichabstracts awayfromtheinessential features ofaprogram, and represents thebasic logical properties ofthealgorithm explicitly. Thecurrent system iscomposed offive parts: ananalyzer thatcan construct theplanforaprogram; acoder that cancreate program text corresponding toaplan; adrawer that candrawagraphical representa- tionofaplan; alibrary ofplans forcommonalgorithmic fragments; andaplaneditor whichmakesitpossible foraprogrammer tomodify aprogram bymodifying its plan. Thegreatest leverage provided bythe system comesfromthefact that aprogrammer canrapidly andaccu- rately build upaprogram byreferring tothefragments inthelibrary andfromthefact thattheeditor provides commandsspecifically de- signed tofacilitate program modification. IndexTerms-Computer-aided design, editing, Lisp, plans, program analysis, programmer's apprentice, program modification, program syn- thesis, program understanding, transformations. /C-O-DE/ 7 1 . ., . . ~~~~~~allows aprogrammer tobuild upaprogramn fromprototypical ment, butrather toaugment it. Itwill communicate with the met,bt-ahrtuietit twUcmuiaewt h fragments, andtomodify aprogram intermsofitslogical rest oftheenvironment interms ofcodeandcommands. Sec-fragmen anto modifaprogrm in ms ofitslogia 1 . . . . . ~~~~~~~~~structure. Inbothcases thesystem gains mostofitspower ona,theprogrammer canstill communicate directly withthe fromthefact thatallofthese actions areperformed onthe
Peptidomic approach, based on liquid chromatography/electrospray ionization tandem mass spectrometry, for detecting sheep's milk in goat's and cow's cheeses (2010)

A common fraud in the dairy field is the addition of sheep's milk to goat's cheeses, because it has a very similar taste to goat's milk, but is more available, and is commonly considered to have a better capacity to curdle. For similar reasons, and due to economic convenience, sheep's cheeses may also contain fraudulent cow's milk. In order to detect this fraud, an EU official method may be used, but it is only a qualitative method (presence/absence of cow's milk). A method able to quantify the presence of sheep's milk during cheese production in goat's and cow's cheeses was developed. The method is based on liquid chromatography/electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS) analysis of peptides of a casein extract from the cheese. By a simple procedure, caseins are extracted from cheeses, solubilized, digested with plasmin, and subsequently analyzed by LC/ESI-MS/MS. A typical sheep's peptide produced by plasmin hydrolysis (m/z = 860) was accurately selected and analyzed to understand if, and by how much, a declared pure goat's cheese contains sheep's milk. By analyzing the same peptide it is also possible to detect if, and by how much, a declared pure sheep's milk contains, or not, cow's milk. The method was applied to several goat's and cow's cheese samples. Quantitation was performed with a calibration curve obtained by analyzing curd cheeses containing different percentages of sheep's milk. The method detection limit and method quantitation limit were evaluated. This method appears accurate and suitable for detecting up to 2% of sheep's milk in cheeses.
Oxygen Tension Regulates the Expression of ANK (<i>Progressive Ankylosis</i>) in an HIF-1-Dependent Manner in Growth Plate Chondrocytes (2009)

The proximal promoter region of ANK, a gene that codes for a protein that regulates the transport of inorganic pyrophosphate, contains two hypoxia responsive elements (HREs); therefore, we studied the expression and function of ANK at different oxygen tensions. ATDC5 and N1511 clonal chondrocytic cells were cultured in either hypoxia (2% O(2)) or normoxia (21% O(2)). Transcript and protein levels of ANK were depressed in hypoxic conditions, as were levels of extracellular pyrophosphate (ePPi). To determine whether HIF-1 was involved in the oxemic response, Hif-1alpha knockdown cells were exposed to varying oxygen conditions and ANK expression was assessed. Knockdown of Hif-1alpha resulted in low levels of expression of ANK in hypoxia and normoxia. Chromatin immunoprecipitation (ChIP) assays explored the binding of Hif-1alpha to ANK HREs and showed that Hif-1alpha is able to bind to the HREs of ANK more avidly in normoxia than in hypoxia. Furthermore, functional studies of Hif-1alpha activity using luciferase reporter assays of wildtype and mutagenized HREs showed that only HRE-1 binds Hif-1alpha in normoxia. Expression of ANK in growth plate and articular cartilage was low in hypoxic regions of the tissues, and higher levels of ANK expression were observed in the synovium and meniscus in regions that have a normally higher oxygen tension. The data suggest that ANK expression and function in vitro and in vivo are repressed in hypoxic environments and that the effect is regulated by HIF-1.
Raman spectroscopy of GaN nucleation and free-standing layers grown by hydride vapor phase epitaxy on oxidized silicon (2003)

GaN nucleation layers (NL-GaN) and GaN free-standing (FS-GaN) layers are studied using Raman spectroscopy and atomic force microscopy. The layers are deposited onto oxidized silicon substrates by hydride vapor phase epitaxy at 520 °C (NL layers) and 970 °C (FS layers). The effect of high-temperature annealing (1010 °C) on the properties of FS-GaN layers is investigated. The average height of the islands in the NL-GaN layers is found to increase from 15 to 400 nm when the growth time is increased from 10 to 200 min. The average growth rate of NLs is found to be very low, namely, ≈1×10−2 nm/s. E2 (566 cm−1) and A1 (longitudinal optical) (730 cm−1) peaks are observed on NL-GaN layers when the average size of the islands increases to 400 nm, scattering by E2 (567.3 cm−1) and E1 [transverse optical (TO)] (558.3 cm−1) modes is detected on FS-GaN layers. High-temperature annealing of the FS-GaN layers results in an increase of the intensity of E2 and E1(TO) peaks detected from the front side whereas no effect is observed for detection from the side exposed by removal of the substrate.
Left Ventricular Diastolic Function in Systemic Sclerosis: Assessment by Radionuclide (1992)

The aim of this study was to assess left ventricular function in subjects with systemic sclerosis. Twenty-four women with systemic sclerosis (mean age 48 ___ 11 yr) and 14 age- and sex-matched normal subjects were studied by radionuclide angiography performed at rest with a temporal resolution of 20 msec/frame. Left ventricular volume curves were generated and indices of systolic and diastolic function were computed. Left ventricular diastolic asynchrony was evaluated by dividing the left ventricle into five regions and then computing the time-to-peak filling rate for each region. After excluding the vatvular region, the coefficient of variation of this index was obtained. The isovolumic relaxation period was prolonged in systemic sclerosis patients in comparison to normal subjects (127 _+ 39 msec versus 87 + 44 msec, p < 0.05). Moreover, 38% of the systemic sclerosis patients had a subnormal peak filling rate. Left ventricular diastolic asynchrony was increased in the systemic sclerosis group, as expressed by a higher coefficient of variation of the regional time to peak filling rate (27.9% ___ 11.5% versus 14.5% _+ 8.6%, p < 0.05). Our results indicate an impaired relaxation and an increased diastolic asynchrony in patients with systemic sclerosis. J Nucl Med 1992; 32:68-72