gebhart/patrepeval huggingface dataset:
QSAR Study on Piperidinecarboxamides as Antiretroviral Agents: An Insight Into the Structural Basis for HIV Coreceptor Antagonist Activity (2008)

Abstract Chemokines receptors have emerged as important drug targets for the development of agents against the Human Immunodeficiency Virus (HIV)/AIDS pandemic. With the purpose of designing new chemical entities with enhanced antiretroviral potencies, the Quantitative Structure–Activity Relationships (QSAR) study carried out on 122 novel piperidin‐4‐carboxamide derivatives as antagonists of HIV Chemokine Receptor 5 (CCR5) coreceptor binding is presented. The developed model was validated by standard QSAR parameters and through a detailed structural investigation on how it explains and reproduces the quantitative differences observed in the experimentally known activity data. The model showed a good correlative and predictive ability having a cross‐validated correlation coefficient ( r 2 cv ) of 0.794 and the conventional correlation coefficient ( r 2 ) was found to be 0.830. The study revealed that the CCR5 antagonistic activity exhibited by the series is largely explained by lipophilicity and steric bulkiness of substituents and that substituents with higher lipophilicity and steric superiority are required to make favorable antagonist–CCR5 interaction chemistry. A detailed investigation was made on the structural basis for the antiretroviral activity and the insights gleaned from the study could be usefully employed to design antagonists with a much more enhanced potency and selectivity.
Triptolide Inhibits Bcr-Abl Transcription and Induces Apoptosis in STI571-resistant Chronic Myelogenous Leukemia Cells Harboring T315I Mutation (2009)

These findings suggest that triptolide is a promising agent to overcome STI571-resistant CML cells, and warrant a clinical trial of triptolide derivatives for CML with Bcr-Abl-T315I mutation.
A Study of Organic Light-Emitting Devices Based on Electrostatic Self-Assembled Films of Evans Blue under AC Voltage (2002)

Light-emitting devices based on layer-by-layer electrostatic self-assembled films of evans blue have been fabricated. Poly (allylamine hydrochloride) with electrostatically attached evans blue molecules has been used as a polycation, while poly (acrylic acid) has been used as a polyanion. Luminance has been observed under both direct-current (dc) and alternating-current (ac) modes. Under dc voltage, luminance has been observed only in forward bias direction, while under ac voltage luminance has been observed under both, forward and reverse bias direction. Moderately high-frequency (50 kHz) electroluminescence (EL) has been obtained from these devices. Transient EL characteristics under a sequence of two voltage pulses have been studied. The light emissions under ac modes have been explained considering the recombination of injected holes (or electrons) with the leftover electrons (or holes) from the previous half-cycle. A correlation between the transient EL response and the frequency dependence of the ac EL has been established. The ac response of the EL has been simulated and compared with experimental results.
Analysis of triangular patch antennas including radome effects (1992)

The full-wave spectral domain technique is used for the first time to analyse the single and covered triangular patch antennas fed by the coaxial probe. The equilateral triangular patch antenna fed by a probe along the patch median was analysed and its input impedance and radiation patterns are presented. The effects of flat radomes on these parameters are studied. To avoid excessive computation time, three sets of basis functions representing the approximate current distributions on the patch are introduced. Merits of each set of basis functions are discussed. Various tests were made to establish the validity of the basis functions, including comparisons of the results against those obtained by the cavity model and against those of some experimental observations.
Learning and Forecasting Opinion Dynamics in Social Networks (2015)

Social media and social networking sites have become a global pinboard for exposition and discussion of news, topics, and ideas, where social media users often update their opinions about a particular topic by learning from the opinions shared by their friends. In this context, can we learn a data-driven model of opinion dynamics that is able to accurately forecast opinions from users? In this paper, we introduce SLANT, a probabilistic modeling framework of opinion dynamics, which represents users opinions over time by means of marked jump diffusion stochastic differential equations, and allows for efficient model simulation and parameter estimation from historical fine grained event data. We then leverage our framework to derive a set of efficient predictive formulas for opinion forecasting and identify conditions under which opinions converge to a steady state. Experiments on data gathered from Twitter show that our model provides a good fit to the data and our formulas achieve more accurate forecasting than alternatives.
Inhibition of tumor angiogenesis by oral etoposide (2010)

The chemotherapeutic agent etoposide is a topoisomerase II inhibitor widely used for cancer therapy. Low-dose oral etoposide, administered at close regular intervals, has potent anti-tumor activity in patients who are refractory to intravenous etoposide; however, the mechanism remains unclear. Since endothelial cells may be more sensitive than tumor cells to chemotherapy agents, we determined the effects of etoposide alone and in combination with oral cyclooxygenase-2 inhibitors and peroxisome-proliferator activated receptor γ ligands on angiogenesis and tumor growth in xenograft tumor models. Optimal anti-angiogenic (metronomic) and anti-tumor doses of etoposide on angiogenesis, primary tumor growth and metastasis were established alone and in combination therapy. Etoposide inhibited endothelial and tumor cell proliferation, decreased vascular endothelial growth factor (VEGF) production by tumor cells and suppressed endothelial tube formation at non-cytotoxic concentrations. In our in vivo studies, oral etoposide inhibited fibroblast growth factor 2 and VEGF-induced corneal neovascularization, VEGF-induced vascular permeability and increased levels of the endogenous angiogenesis inhibitor endostatin in mice. In addition, etoposide inhibited Lewis lung carcinoma (LLC) and human glioblastoma (U87) primary tumor growth as well as spontaneous lung metastasis in a LLC resection model. Furthermore, etoposide had synergistic anti-tumor activity in combination with celecoxib and rosiglitazone, which are also oral anti-angiogenic and anti-tumor agents. Etoposide inhibits angiogenesis in vitro and in vivo by indirect and direct mechanisms of action. Combining etoposide with celecoxib and rosiglitazone increases its efficacy and merits further investigation in future clinical trials to determine the potential usefulness of etoposide in combinatory anti-angiogenic chemotherapy.
Cloning and Expression of Human Insulin-Like Growth Factor Binding Protein 3 (1990)

Insulin-like growth factors (IGFs) found in plasma and other body fluids circulate in association with specific binding proteins. We report here the cloning and the nucleotide sequence of cDNAs for the growth-hormone-dependent acid-stable IGF binding protein, hIGF-BP3. The derived protein begins with a putative 27-amino acid signal peptide followed by 264 residues of the mature polypeptide. The predicted sequence contains three potential N-linked glycosylation sites and shares two region of homology with the low-molecular-weight non-growth-hormone-dependent binding proteins BP-1 and BP-2. The protein contains 18 cysteine residues clustered in the amino and carboxy termini. Chinese Hamster ovary cells transfected with this cDNA secrete a 43-45 kD protein doublet, which bound IGF. The expressed IGF-binding protein is indistinguishable from the native BP-3 found in human plasma.
Variable-angle correlation spectroscopy in solid-state nuclear magnetic resonancea) (1992)

We describe here a new solid-state nuclear-magnetic-resonance (NMR) experiment for correlating anisotropic and isotropic chemical shifts of inequivalent nuclei in powdered samples. Spectra are obtained by processing signals arising from a spinning sample, acquired in independent experiments as a function of the angle between the axis of macroscopic rotation and the external magnetic field. This is in contrast to previously proposed techniques, which were based on sudden mechanical flippings or multiple-pulse sequences. We show that the time evolution of variable-angle-spinning signals is determined by a distribution relating the isotropic frequencies of the spins with their corresponding chemical shift anisotropies. Fourier transformation of these data therefore affords a two-dimensional NMR spectrum, in which line shapes of isotropic and anisotropic interactions are correlated. Theoretical and experimental considerations involved in the extraction of this spectral information are discussed, and the technique is illustrated by an analysis of 13C NMR anisotropy in glycine, cysteine, and p-anisic acid.
Controlled source electromagnetic (CSEM) technique for detection and delineation of hydrocarbon reservoirs: an evaluation (2005)

The resolving capabilities of marine Controlled Source Electromagnetic technique are evaluated on various theoretical models of finite lateral extent, both horizontal and dipping. We analyze the effects of variable bathymetry and of salt underlying the targets, and also present novel ways of displaying data for multiple transmitter‐receiver locations.
Hormone-induced 14-3-3γ Adaptor Protein Regulates Steroidogenic Acute Regulatory Protein Activity and Steroid Biosynthesis in MA-10 Leydig Cells (2012)

Cholesterol is the sole precursor of steroid hormones in the body. The import of cholesterol to the inner mitochondrial membrane, the rate-limiting step in steroid biosynthesis, relies on the formation of a protein complex that assembles at the outer mitochondrial membrane called the transduceosome. The transduceosome contains several mitochondrial and cytosolic components, including the steroidogenic acute regulatory protein (STAR). Human chorionic gonadotropin (hCG) induces de novo synthesis of STAR, a process shown to parallel maximal steroid production. In the hCG-dependent steroidogenic MA-10 mouse Leydig cell line, the 14-3-3γ protein was identified in native mitochondrial complexes by mass spectrometry and immunoblotting, and its levels increased in response to hCG treatment. The 14-3-3 proteins bind and regulate the activity of many proteins, acting via target protein activation, modification and localization. In MA-10 cells, cAMP induces 14-3-3γ expression parallel to STAR expression. Silencing of 14-3-3γ expression potentiates hormone-induced steroidogenesis. Binding motifs of 14-3-3γ were identified in components of the transduceosome, including STAR. Immunoprecipitation studies demonstrate a hormone-dependent interaction between 14-3-3γ and STAR that coincides with reduced 14-3-3γ homodimerization. The binding site of 14-3-3γ on STAR was identified to be Ser-194 in the STAR-related sterol binding lipid transfer (START) domain, the site phosphorylated in response to hCG. Taken together, these results demonstrate that 14-3-3γ negatively regulates steroidogenesis by binding to Ser-194 of STAR, thus keeping STAR in an unfolded state, unable to induce maximal steroidogenesis. Over time 14-3-3γ homodimerizes and dissociates from STAR, allowing this protein to induce maximal mitochondrial steroid formation.
Frequent itemset mining on graphics processors (2009)

We present two efficient Apriori implementations of Frequent Itemset Mining (FIM) that utilize new-generation graphics processing units (GPUs). Our implementations take advantage of the GPU's massively multi-threaded SIMD (Single Instruction, Multiple Data) architecture. Both implementations employ a bitmap data structure to exploit the GPU's SIMD parallelism and to accelerate the frequency counting operation. One implementation runs entirely on the GPU and eliminates intermediate data transfer between the GPU memory and the CPU memory. The other implementation employs both the GPU and the CPU for processing. It represents itemsets in a trie, and uses the CPU for trie traversing and incremental maintenance. Our preliminary results show that both implementations achieve a speedup of up to two orders of magnitude over optimized CPU Apriori implementations on a PC with an NVIDIA GTX 280 GPU and a quad-core CPU.
Thermal design and measurements of IGBT power modules: transient and steady state (2003)

The spatial temperature distributions on IGBT devices in 6-pack power modules have been measured during both transient and steady-states using ultra high speed infrared microscopy. Power modules examined included a commercial 6-pack module and a miniaturized inverter. The modules were constructed using both Al/sub 2/O/sub 3/ and AlN direct bond copper (DBC) substrates and an insulated metal substrate (IMS). The effects of IGBT bonding pad design and layout, bond wire arrangement and module curvature on the temperature distribution were measured and analyzed. Thermal performances of all the modules were characterized by the junction-to-case, case-to-sink and sink-to-ambient thermal resistance. The trade-offs between AlN, Al/sub 2/O/sub 3/, and IMS substrates and the replacement of conventional solder with a conductive adhesive are discussed from thermal, reliability and cost viewpoints.
Pharmacokinetic Effects of Diphenhydramine or Oxycodone in Simulated Acetaminophen Overdose (2005)

To determine the effects of co-ingested diphenhydramine (DPH) or oxycodone (OXY) on the absorption kinetics of simulated acetaminophen (APAP) overdose.This was an institutional review board-approved, prospective crossover study of ten healthy human volunteers ingesting 5 grams of APAP, 5 grams of APAP + 250 mg of DPH (APAP+DPH), or 5 grams of APAP + 0.5 mg/kg of OXY (APAP+OXY). Serum APAP concentrations (APAPs) were measured hourly from zero through eight hours and again at 24 hours, and basic noncompartmental pharmacokinetic parameters were compared.For APAP alone, the mean parameters were: maximum APAP concentration ([APAP](max)) 71.8 microg/mL, time to peak [APAP] (t(max)) 1.71 hours, and area under the receiver operating characteristic curve (AUC(0-8)) 318.3 microg-hr/mL. For APAP+DPH, the mean parameters were: [APAP](max) 67.6 microg/mL, t(max) 1.90 hours, and AUC(0-8) 297.7 microg-hr/mL. For APAP+OXY, the parameters were: [APAP](max) 42.9 microg/mL, t(max) 2.87 hours, and AUC(0-8) 232.1 microg-hr/mL. Compared with APAP alone, APAP+OXY had a 27% lower AUC, a 40% lower [APAP](max), and a 68% longer t(max). Co-ingested DPH had no significant effect on APAP absorption, except a 6% decrease in the AUC.Co-ingested OXY, but not DPH, delayed absorption of APAP. This suggests a potential role for activated charcoal administration beyond one hour postingestion after mixed ingestions that include OXY.
Patterns of Changes in Human Immunodeficiency Virus Type 1 V3 Sequence Populations Late in Infection (2000)

We have used a V3-specific heteroduplex tracking assay (V3-HTA) with probes from two different human immunodeficiency virus type 1 (HIV-1) subtypes to examine the extent and pace of HIV-1 evolution late in infection. Twenty-four subjects with advanced HIV-1 infection (CD4(+) T-cell count, <100/microl) and stable viral loads were studied using blood plasma samples collected over a study period of approximately 9 months, during which time most of the subjects were treated with reverse transcriptase inhibitors. The V3-HTA patterns from the first and last time points were evaluated initially to determine the amounts of change in V3 sequence populations, which were primarily changes in abundance in preexisting sequence populations. Three of the 24 subjects had major changes (greater than 50% total change in the relative abundance of the sequence populations), 11 subjects had intermediate changes (10 to 50% total change), and 10 subjects had minimal changes (less than 10% total change). The average total amount of change was between two- and threefold greater in subjects with X4-like variants, although there was no correlation between average viral load and the presence of X4-like variants. V3-HTA patterns in monthly samples from 11 of the subjects were also compared. In two subjects, the amount of change exceeded 40% in a 1-month period. Overall, the pace of change in V3 populations varied between subjects and was not constant within a subject over time. Sequence analysis of the V3 variants showed that R5-like variants (not containing any X4-associated substitutions) continued to be maintained in three subjects in the presence of X4-like variants, indicating that X4 variants do not always outgrow R5 variants. The coreceptor usage of the V3 sequences from two subjects was determined using a cell fusion assay. One subject had an X4 variant that was maintained at a low level for at least 9 months, during which time the predominant variants were R5X4 (dualtropic), while in the second subject the reverse situation was observed. One of the dualtropic variants had a novel sequence motif in V3, suggesting another evolutionary pathway to altered tropism. These studies begin to probe the complexities and pace of V3 evolution in vivo, revealing dynamic patterns of change among multiple V3 sequence variants in a subset of subjects.
Practical Points in Urinary Proteomics (2007)

During the proteomic era, one of the most rapidly growing areas in biomedical research is biomarker discovery, particularly using proteomic technologies. Urinary proteomics has become one of the most attractive subdisciplines in clinical proteomics, as the urine is an ideal source for the discovery of noninvasive biomarkers for human diseases. However, there are several barriers to the success of the field and urinary proteome analysis is not a simple task because the urine has low protein concentration, high levels of salts or other interfering compounds, and more importantly, high degree of variations (both intra-individual and inter-individual variabilities). This article provides step-by-step practical points to perform urinary proteome analysis, covering detailed information for study design, sample collection, sample storage, sample preparation, proteomic analysis, and data interpretation. The discussion herein should stimulate further discussion and refinement to develop guidelines and standardizations for urinary proteome study.
High temperature superconducting 8.45-GHz bandpass filter for the Deep Space Network (2002)

A high-temperature superconducting (HTS) stripline 8.45-GHz bandpass filter, designed for the Deep Space Network, is presented. It has very low insertion loss, indicative of resonators with unloaded Q's greater than 10000. The performance of this filter shows that practical, high-Q multiresonator devices can be constructed using lanthanum aluminate substrates in a stripline configuration. The HTS films used in this filter were of the thallium barium calcium copper oxide (TBCCO) variety, deposited on a lanthanum aluminate substrate using laser ablation and postdeposition thermal processing. The HTS surface resistance of these TBCCO films is less than 0.5 m Omega at 10 GHz and facilitates the construction of planar HTS resonators with unloaded Q's greater than 10000 at 10 GHz. HTS planar circuits with these Q's are very useful in constructing narrow-bandwidth filters due to the resulting very low minimum insertion loss.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Silver catalyzed intramolecular cyclization for synthesis of 3-alkylideneoxindoles via C–H functionalization (2011)

A novel protocol for the preparation of various 3-alkylideneoxindoles via a silver-catalyzed aromatic C-H functionalization has been developed. The process is simple, environmentally conscious, and avoids the use of abundant bases, oxidants, or other additives.
Titanocene Dichloride—The First Metallocene with Cancerostatic Activity (1979)

The cancerostatic activity of metal complexes can be tested on mice by injection of tumor cells and, 24 h later, the substance to be investigated. Compound (1), selected partly because of its structural similarity to the antitumor agent (2), exhibited a cure rate of over 80% in the therapeutic range.
Low-Leakage Storage Cells for Ternary Content Addressable Memories (2009)

Innovative architectural and circuit techniques are reducing the dynamic power in ternary content addressable memories (TCAMs). Also, shrinking device dimensions are making transistors increasingly leaky. Due to these two trends, the static power is becoming a significant portion of the total TCAM power. This paper presents two novel ternary storage cells that exploit the unique properties of TCAMs for reducing the cell leakage. Simulation results of the proposed cells show up to 40% leakage reduction over the conventional TCAM cell at the expense of a small degradation (<8%) in the static noise margin (SNM). The SNM degradation is negligible (<1%) for lower power supply voltages (<0.8 V). Measurement results of a test chip in 0.18-mum CMOS technology demonstrate that the proposed cells can perform read and write operations in less than 3.6 ns.
Simple goniometer for precise grinding and electropolishing of single crystal surfaces (1977)

A simple goniometer, which can be used to rigidly support a crystal in a precise orientation through all phases of surface preparation, including mechanical, chemical, and electrochemical polishing, is described.
Formation of gas-phase .pi.-allyl radicals from propylene over bismuth oxide and .gamma.-bismuth molybdate catalysts (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFormation of gas-phase .pi.-allyl radicals from propylene over bismuth oxide and .gamma.-bismuth molybdate catalystsWilson Martir and Jack H. LunsfordCite this: J. Am. Chem. Soc. 1981, 103, 13, 3728–3732Publication Date (Print):July 1, 1981Publication History Published online1 May 2002Published inissue 1 July 1981https://pubs.acs.org/doi/10.1021/ja00403a019https://doi.org/10.1021/ja00403a019research-articleACS PublicationsRequest reuse permissionsArticle Views520Altmetric-Citations82LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts