gebhart/patrepeval huggingface dataset:
Pharmacology (1998)

Inadequate pain relief has been identified as a common problem after coronary artery bypass surgery, Understanding the pharmacology of analgesics commonly used after cardiovascular surgery is a fundamental part of effective pain management. The pharmacologic properties for two analgesic drug classes, opioid and nonopioid, are reviewed. Major drugs in each class are discussed in terms of their pharmacodynamic and pharmacokinetic properties.
Nuclear migration and mitochondrial inheritance in the mushroom agaricus bitorquis. (1988)

Mitochondrial (mt) DNA restriction fragment length polymorphisms (RFLPs) were used as genetic markers for following mitochondrial inheritance in the mushroom Agaricus bitorquis. In many basidiomycetes, bilateral nuclear migration between paired homokaryotic mycelia gives rise to two discrete dikaryons which have identical nuclei but different cytoplasms. Although nuclear migration is rare in A. bitorquis, unidirectional nuclear migration occurred when a nuclear donating strain (8-1), was paired with a nuclear recipient strain (34-2). The dikaryon recovered over the nuclear recipient mate (Dik D) contained nuclei from both parents but only mitochondria from the recipient mate; thus nuclei of 8-1, but not mitochondria, migrated through the resident hyphae of 34-2 following hyphal anastomosis. The two mitochondrial types present in a dikaryon recovered at the junction of the two cultures (Dik A) segregated during vegetative growth. Dikaryotic cells having the 34-2 mitochondrial type grew faster than cells with the 8-1 mitochondrial type. Fruitbodies, derived from a mixed population of cells having the same nuclear components but different cytoplasms, were chimeric for mitochondrial type. The transmission of mitochondria was biased in favor of the 8-1 type in the spore progeny of the chimeric fruitbody. Protoplasts of dikaryon (Dik D), which contained both nuclear types but only the 34-2 mitochondrial type, were regenerated and homokaryons containing the 8-1 nuclear type and the 34-2 mitochondrial type were recovered.
Synthesis of 2-Acyl-1-benzyl-, 1-phenylethyl- and spirobenzyltetrahydroisoquinolines (1996)

Abstract N-Acyl-1-benzyl-, 1-phenylethyl-and 1-spirobenzyltetrahydro-isoquinolines are obtained from N-acyl-2-phenylethylamines and arylalkyl aldehydes or cyclic ketones in acidic media.
Improved combined radar/radiometer rain profiling (2002)

The current TRMM combined radar/radiometer profiling algorithm compensates for the known shortcomings of each instrument by exploiting the strengths of the other. It turns out that the strengths/weaknesses of the radiometer measurements are not as they seemed before TRMM. Specifically, the current algorithm presumes that the radiances at the various frequencies are approximately independent (to compute probability weights). It turns out there are strong correlations between the channels. New estimates of the conditional covariance of the radiances given the rain should make the probability weights more realistic. The second problem stems from the representativity of the TRMM cloud database. It turns out that the database is significantly off, especially at higher frequencies. To reduce the rain over-estimation produced by this discrepancy, the database was re-sampled and mean rain-radiances relations were re-derived. The third problem is the lack of any ice estimates. The reason was the large number of unknown variables involved. A principal component analysis has revealed that the frozen hydrometeor profiles can be approximated by a single variable each for ice, snow, and graupel. A straightforward method is currently being implemented to estimate these additional variables, and to include them in the output structure of the algorithm. Linear formulas will enable users to reconstruct the corresponding graupel/snow/ice profiles, and estimate the corresponding latent heating.
Microwave Assisted Synthesis of 1-Aryl-3-dimethylaminoprop-2-enones: A Simple and Rapid Access to 3(5)-Arylpyrazoles (2001)

Condensation of aromatic acyl compounds with N,N-dimethylformamide diethyl acetal in a pressure tube under microwave heating gives 1-aryl-3-dimethylaminoprop-2-enones in almost quantitative yields. In the presence of hydrazine, these intermediates are transferred to the corresponding 3-arylpyrazoles.
Is percutaneous vertebroplasty without pretreatment venography safe? Evaluation of 205 consecutives procedures. (2002)

PV can, in our experience, be performed safely without prior angiographic evaluation of the vertebral venous system.
Adaptive Snoop Granularity and Transactional Snoop Filtering in Hardware Transactional Memory (2014)

Hardware transactional memory (HTM) offers a promising parallel programming model for chip multiprocessors. The performance aspect of HTMs has been explored extensively, whereas little research has addressed the power of HTMs. In this paper, we investigate power consumption in HTMs and propose two optimization techniques. The first optimization technique is adaptive snoop granularity (ASG). HTMs rely on cache coherence protocols to detect conflicts and maintain consistency of transactional data. One of the main design issues facing HTMs is the growing number of snoops required to maintain coherency of transactional data. We found that many transactions access consecutive memory locations which are not shared by other transactions. ASG monitors these transactional accesses and dynamically changes snoop granularity to reduce the power of the interconnection network and eliminate needless cache snoops. The second optimization technique is transactional snoop filtering (TSF). TSF dynamically tracks accesses to the coherence caches and eliminates cache snoops that would result in cache misses. TSF relies on small filters to monitor cache addresses. Energy is reduced as accesses to the much more demanding data caches are decreased. We extended the Gem5 simulator to model ASG and TSF. Our simulation results show that ASG and TSF are effective and reduce energy of interconnects and caches up to 44% and 89%, respectively.
22 Heat Shock Protein Gene Expression in Response to Physiologic Stress and Aging (1994)

I. INTRODUCTION Human aging is accompanied by a progressive decline in physiologic processes and in particular by a decreased ability to maintain homeostasis when faced with the stresses of life (Shock 1961; Shock et al. 1984). Current concepts suggest that aging results at least in part from damage to molecules, cells, and tissues by a variety of toxic factors that either are endogenously produced or occur as a result of environmental exposure (Martin et al. 1993). Genetic systems have evolved to detect specific forms of damage and to activate the expression of genes whose products are presumed to increase the resistance of cells to such damage and/or to aid in its repair. Believing that the continued effectiveness of these genetic responses to stress may be a major factor in resistance to disease and aging, we initiated a series of studies to examine the expression of various stress response genes as a function of aging. Because the expression of heat shock proteins is the most highly conserved and best understood of these genetic stress responses, and because the beneficial effects of heat shock proteins during stress have been clearly documented, we have focused efforts on this group of proteins. Most of our knowledge concerning the homeostatic role of heat shock proteins has come from studies using cultured cells. Although much less is known about their expression in vivo, heat shock proteins are induced acutely in the intact animal in response to localized tissue injury, as well as systemically following heat stress...
Generalized compliant motion task description and execution within a complete telerobotic system (2002)

A motion primitive for use in compliant motion robot task execution is described. The primitive has a rich input parameter set to provide for execution of a variety of specific tasks such as door opening, crank turning, bolt seating and turning, pushing, sliding, pin insertion/removal, and leveling, as well as termination conditions which specify conditions for ending the motion, such as allowable position and force error bounds. A split rate force control technique is used for force control. Force and torque data from a six-axis force sensor are read, and gravity compensation using load mass properties is done to determine contact forces
A NATURAL LANGUAGE APPROACH TO MULTI-WORD TERM CONFLATION (1997)

This paper presents a corpus-based system to expand multi-word index terms using a part-of-speech tagger and a fullfledged derivational morphological system, combined with a shallow parser. The unique contribution of the research is in using these linguistically based tools with filters in order to avoid the problems of semantic degradation typically associated with derivational analysis. The expansion and subsequent conflation of terms increases indexing coverage up to 30%, with precision of nearly 90% for correct identification of related terms. The system core is language independent and provides a uniform platform on which to build multilingual applications. Language specific modules have been developed for English and French. The fully implemented system is described with particular attention to the role of derivational morphology and phrasal relations. Results and evaluation will be presented in terms of precision and recall, with an analysis of errors. This paper illustrates how...
Inhibition of streptococcal attachment to receptors on human buccal epithelial cells by antigenically similar salivary glycoproteins (1975)

Preparations of salivary glycoproteins inhibited the attachment of certain indigenous oral streptococci to human buccal epithelial cells and fostered the desorption of previously attached bacteria. The adherence-inhibiting and desorptive activities of the glycoproteins correlated with their ability to aggregate these organisms. Pretreatment of glycoprotein preparations with certain blood group antisera impaired their adherence-inhibiting effect, suggesting that components with blood group substance reactivity were involved. Pretreatment of buccal epithelial cells with certain blood group antisera or concanavalin A masked the receptors associated with the attachment of Streptococcus sanguis SG1. The association of blood-group-reactive substances with the receptors involved in bacterial attachment may provide a basis for understanding the distinct specificities that bacteria exhibit for attaching to different tissues, organs, and hosts. Antiserum raised in rabbits to human epithelial cells also exhibited receptor-masking activity, and absorption of this serum with homologous salivary glycoproteins removed the antibodies responsible. These observations indicate that some salivary glycoproteins are antigenically similar to components on the epithelial cell surfaces they bathe. It is suggested that by mimicking the receptors present on epithelial cells, the mucinous glycoproteins of secretions may competitively inhibit the sorption of infectious agents and facilitate their removal after they are attached. These activities help to explain how mucinous glycoproteins augment the cleansing action of secretions.
Fibrosis in the kidney: is a problem shared a problem halved? (2012)

Fibrotic disorders are commonplace, take many forms and can be life-threatening. No better example of this exists than the progressive fibrosis that accompanies all chronic renal disease. Renal fibrosis is a direct consequence of the kidney's limited capacity to regenerate after injury. Renal scarring results in a progressive loss of renal function, ultimately leading to end-stage renal failure and a requirement for dialysis or kidney transplantation. Although it manifests itself histologically as an increase in extracellular matrix, we know that the histological appearance can be caused by a de novo synthesis of matrix (primarily collagen), or a disproportionate loss of renal parenchyma. In both cases the process depends on a resident mesenchymal cell, the so-called myofibroblast, and is independent of disease etiology. Potentially we can ameliorate fibrosis, either indirectly by modifying the environment the kidney functions in, or more directly by interfering with activation and function of myofibroblasts. However, while renal fibrosis shares many features in common with the wound healing response in other organs, we also recognise that the consequences can be highly kidney specific. This review highlights the similarities and differences between this process in the kidney and other organs, and considers the therapeutic implications.
Prime-factor Hartley and Hartley-like transform calculation using transversal filter-type structures (1989)

The advances in digital fabrication technology have led to a new generation of integrated circuits capable of performing fast arithmetic operations, and opened the door to the consideration of algorithms that may be implemented with simple structures. When the number of data samples in the input block is prime or a product of primes, the Hartley transform can readily be mapped to circular convolutions and then implemented using transversal filter-type structures. Such a structure is simple and regular, and hence it is suitable for VLSI implementation. The Hartley transform is real-to-real and it is the same for both forward and inverse transformations. Hence, it is simpler and may therefore be somewhat faster than the DFT implemented by the same approach.
Selective iodide chemosensing through a redox-active Cu-corrole (2014)

A one-electron redox couple between iodide and Cu(<sc>iii</sc>)-corrole serves as the basis for selective sensing of iodide.
Genetic Disorders and the Fetus: Diagnosis, Prevention, and Treatment (2015)

definitive reference work on prenatal diagnosis, Genetic Disorders and the Fetus is now available in a completely revised and updated fifth edition reflecting the most current advances in research, technology, and clinical care. Written by an international team of experts, the volume provides in-depth critical analysis of the latest work in prenatal diagnosis of genetic and other disorders. Topics include: fragile X syndrome, cystic fibrosis, neural tube defects, and hemoglobinopathies; the experience and techniques of amniocentesis, chorionic villus sampling, ultrasound, fetal blood sampling; abortion and fetal therapy; and medicolegal and ethical issues in prenatal diagnosis. book describes the use of combined biochemical markers to screen for neural tube and chromosomal defects, presents the latest developments relating to testing fetal cells in the mother's blood, and reviews major advances in molecular genetics that permit prenatal carrier detection and presymptomatic and predictive testing. Much has changed since the publication of the fourth edition. new technologies of fetal MRI, 3-D ultrasound, and real time PCR of fetal DNA in maternal circulation yield crucial information. While, integrated screening of data from the first and second trimesters coupled with ultrasound now produces a 94 percent detection rate. From reviews of the fourth edition: The editor is to be congratulated on producing such a topical and full summary of current practice and future developments. This book would make a most useful addition to the libraries of both genetic and fetal medicine departments.--Journal of Medical Genetics Perinatology and the care of the newborn are two of the most exciting fields of medicine and have been characterized by tremendous advances over the past three decades ...[This book] accurately reflects this progress and captures the excitement that characterizes these endeavors. Long considered a standard reference in the area of prenatal diagnosis, this text is notable for its breadth and continues to be a readable, well-organized, comprehensive resource for clinicians in fields related to the care of the fetus and newborn ...For those engaged in prenatal, perinatal, and neonatal diagnosis, this [edition] is recommended for your library. --JAMA One great strength of Milunsky's book is that these authoritative chapters ...succeed in imparting data, wisdom, and pitfalls clearly and concisely.--Human Genetics It would provide an excellent teaching text for clinicians in training and a useful reference text for many scientists working on the laboratory side of prenatal genetic testing ...This text is a must for any obstetrics library shelf.--Journal of Obstetrics and Gynaecology.
Nova dieta merídica para criação de Hypothenemus hampei (Ferrari) (Coleoptera: Scolytidae) (1993)

New Meridic Diet for Rearing Hypothenemus hampei (Ferrari) (Coleoptera: Scolytidae)More than 140 diets recipies in which were combined quality, quantity, texture of the ingredients and way of the diet preparation were tested ia order to reduce cost of production and to develop a commerciai diet for the coffee berry borer, Hypothenemus hampei (Ferrari).The new simple diet contains: boiled water coffee beans meal, sugar, torula yeast, casem, wesson salts, agar, ethanol and antibiotic ingredients.
Selective 5-HT1D alpha serotonin receptor gene expression in trigeminal ganglia: implications for antimigraine drug development. (1994)

Pharmacological data suggest that the actions of antimigraine drugs such as sumatriptan may be mediated by 5-HT1D-like serotonin receptors on trigeminovascular nerve endings. We sought molecular evidence for the expression of an mRNA species encoding the 5-HT1D receptor subtype in guinea pig and human trigeminal ganglia, using the polymerase chain reaction with oligonucleotides uniquely homologous to the coding sequences of the 5-HT1B/D family (human 5-HT1D alpha and 5-HT1D beta; rat 5-HT1B). A single band of predicted size was observed in samples from guinea pig trigeminal ganglia; sequence analysis revealed the presence of a single message, which was 85% and 71% identical to the human 5-HT1D alpha and 5-HT1D beta receptor DNA sequences, respectively. Similar analyses of postmortem human trigeminal ganglia revealed the presence of 5-HT1D alpha, but not 5-HT1D beta, receptor message. Inasmuch as one recent report found that mRNA encoding only the 5-HT1D beta receptor subtype was expressed by vascular smooth muscle of the central nervous system, the present findings suggest the importance of developing selective 5-HT1D alpha receptor agonists as a strategy to reduce the risk of myocardial infarction and possibly stroke that complicates the acute treatment of migraine headache.
A solution-processed 1.53 μm quantum dot laser with temperature-invariant emission wavelength (2006)

Sources of coherent, monochromatic short-wavelength infrared (1-2 mum) light are essential in telecommunications, biomedical diagnosis, and optical sensing. Today's semiconductor lasers are made by epitaxial growth on a lattice-matched single-crystal substrate. This strategy is incompatible with integration on silicon. Colloidal quantum dots grown in solution can, in contrast, be coated onto any surface. Here we show a 1.53 mum laser fabricated using a remarkably simple process: dipping a glass capillary into a colloidal suspension of semiconductor quantum dots. We developed the procedures to produce a smooth, low-scattering-loss film inside the capillary, resulting in a whispering gallery mode laser with a well-defined threshold. While there exist three prior reports of optical gain in infrared-emitting colloidal quantum dots [1,2,3], this work represents the first report of an infrared laser made using solution processing. We also report dlambda(max)/dT, the temperature-sensitivity of lasing wavelength, of 0.03 nm/K, the lowest ever reported in a colloidal quantum dot system and 10 times lower than in traditional semiconductor quantum wells.
Thermal Reaction of Ethylene with Acetylene (1942)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThermal Reaction of Ethylene with AcetyleneErnest A. Naragon, Robert E. Burk, and Herman P. LankelmaCite this: Ind. Eng. Chem. 1942, 34, 3, 355–358Publication Date (Print):March 1, 1942Publication History Published online1 May 2002Published inissue 1 March 1942https://pubs.acs.org/doi/10.1021/ie50387a023https://doi.org/10.1021/ie50387a023research-articleACS PublicationsRequest reuse permissionsArticle Views74Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Meta-analysis to investigate relationships between somatic cell count and raw milk composition, Cheddar cheese processing characteristics and cheese composition (2013)

The relationship between elevated somatic cell count (SCC) and raw milk composition,\ncheese processing and cheese composition, was investigated by meta-analysis\nusing available literature representing 45 scientific articles. With respect to raw milk\ncomposition there was a significant positive relationship between SCC and the protein\nand fat contents and a significant negative relationship between SCC and the lactose\ncontent. In relation to cheese processing, there was a significant negative relationship\nbetween SCC and recoveries of protein and fat. As SCC increased cheese protein content\ndeclined and cheese moisture content increased.
[Enzymes of the inosinic crossing point in human lymphocytes]. (1990)

At the "inosinic branch point", inosinic acid (IMP) can be channelled either to guanylic acid (GMP) or to adenylic acid (AMP). The 4 enzymes involved in these processes are IMP-dehydrogenase (IMP-DH) and GMP synthetase for the formation of GMP and adenylosuccinate (AMP-S) synthetase and lyase for the formation of AMP. The Authors study the behavior of these enzymes in peripheral blood lymphocytes from normal and leukemic patients. The cells were isolated as previously reported. GMP synthetase was assayed with radiochemical method, IMP-DH and AMP-S synthetase with a radiochemical method coupled to HPLC, while AMP-S lyase was determined following the formation of AMP separated by AMP-S by HPLC, without using labelled precursors. Except for GMP synthetase, which was very low, no activity was detectable in normal lymphocytes; while AMP-S was absent also in leukemic cells, the remaining three activities were well evident. The results open the possibility of using the inosinic branch point enzymes as tumor markers.