gebhart/patrepeval huggingface dataset:
Effects of Colicins E1 and K on Transport Systems (1969)

The effect of colicins E1 and K on active transport of beta-d-galactosides and of alpha-methyl-d-glucoside (alphaMG) by Escherichia coli was studied. These colicins strongly inhibited the accumulation of thio-methyl-galactoside (TMG) by bacteria and caused rapid exit of previously accumulated TMG. The inhibition effect was limited to the accumulation phase of galactoside transport; the rate of hydrolysis of o-nitrophenyl galactoside, which is dependent on transport of the substrate by the lactose-permease system, was only slightly affected. The accumulation of alphaMG was highly resistant to inhibition by these colicins under conditions which caused complete suppression of TMG accumulation. These effects of the colicins on transport resemble qualitatively those of sodium azide. The findings were interpreted by assuming that colicins E1 and K inhibit the energy-dependent steps in the accumulation of TMG but do not affect facilitated diffusion of galactosides mediated by the specific transport mechanism. The continued accumulation of alphaMG was attributed to the fact that this compound is stored by E. coli cells as a phosphorylated compound by a phosphoenolpyruvate-dependent transport system rather than by an adenosine triphosphate-linked accumulation mechanism.
Unconstrained correlation filters (1994)

A mathematical analysis of the distortion tolerance in correlation filters is presented. A good measure for distortion performance is shown to be a generalization of the minimum average correlation energy criterion. To optimize the filter's performance, we remove the usual hard constraints on the outputs in the synthetic discriminant function formulation. The resulting filters exhibit superior distortion tolerance while retaining the attractive features of their predecessors such as the minimum average correlation energy filter and the minimum variance synthetic discriminant function filter. The proposed theory also unifies several existing approaches and examines the relationship between different formulations. The proposed filter design algorithm requires only simple statistical parameters and the inversion of diagonal matrices, which makes it attractive from a computational standpoint. Several properties of these filters are discussed with illustrative examples.
Porcine Luteinizing Hormone Isoform(s): Relationship between Their Molecular Structures, and Renotropic<i>Versus</i>Gonadotropic Activities* (1989)

We recently demonstrated the renotropic activity in ovine LH isoform(s). In this study we purified porcine (p) LH isoforms and analyzed their structures and bioactivities. Purified pLH preparation (G-100 fraction 3) was dissociated into alpha- and beta-subunits, followed by isolation with reverse phase HPLC. Six components were isolated and analyzed for their amino acid compositions and amino-terminal amino acid sequences. alpha-Subunits were found to have heterogeneous N-terminal sequences, which started at Phe-1, Gly-4, Phe-6, or Thr-7. This N-terminal heterogeneity and the presence of the initial 6 amino acids has not been reported previously to the best of our knowledge. Moreover, the first 10 residues, Phe-Pro-Asp-Gly-Glu-Phe-Thr-Met-Gln-Gly, were identical with those of the ovine LH alpha subunit. At least 3 different beta-subunits were identified as heterogeneous in their carboxyl-terminal amino acids. The pLH preparation (G-100-fraction 3) was then chromatographed by an isoelectrofocusing (IEF) column. Four IEF fractions were obtained. Their amino acid structures appeared to be identical, as judged by the identical elution profiles on reverse phase HPLC, but their carbohydrate compositions were slightly different, especially in N-acetylgalactosamine in alpha-subunits. Thus, fractionation on IEF depended on the heterogeneity in carbohydrate structures. Each IEF fraction had different potencies in terms of its gonadotropic activity (in vitro) and renotropic activity (in vivo and in vitro). The discrepancy was observed not only between gonadotropic activity and renotropic activity, but also between in vivo and in vitro renotropic activity. This study identified the structural heterogeneity of pLH isoforms and demonstrated their biological heterogeneity. We concluded that the carbohydrate structure of the pLH isoform is important for expressing its biological heterogeneity (gonadotropic and renotropic activity.
Dynamic Response of Grid-Connected Wind Turbine with Doubly Fed Induction Generator during Disturbances (2004)

The use of the Doubly-fed Induction Generator (DFIG) in large wind turbines (MW-class) is growing rapidly. In order to investigate the dynamic response of a wind turbine withDFIG connected to the power system during grid disturbance, a model has been developed. This model includes aerodynamics, the mechanical drive train, the induction generator as well as the control parts. The response of the system during grid disturbances is studied. An inclusion of saturation effect in the generator during faults is included as well.
Properties of Passivation Film on Silicon due to HF–NO<sub>2</sub> Mixed Gas Reaction (1983)

The properties and formation mechanism of a surface passivation film on silicon are discussed. The film is produced by a staining reaction in a mixed HF–NO 2 gas, followed by a subsequent low temperature oxidation. It is found that the stain film formation reaction is accompanied by the surface etching reaction. From experiments by varying the composition of the mixed gas and conditions of the treatment, it is found that particularly NO 2 gas component has an important bearing on the film forming and etching reactions. These reactions are independent of the conductivity type or the specific resistivity of the silicon. The present surface passivating film results in surface stabilization of silicon devices by having high breakdown voltage.
Multiple-point equalization of room transfer functions by using common acoustical poles (1997)

A multiple-point equalization filter using the common acoustical poles of room transfer functions is proposed. The common acoustical poles correspond to the resonance frequencies, which are independent of source and receiver positions. They are estimated as common autoregressive (AR) coefficients from multiple room transfer functions. The equalization is achieved with a finite impulse response (FIR) filter, which has the inverse characteristics of the common acoustical pole function. Although the proposed filter cannot recover the frequency response dips of the multiple room transfer functions, it can suppress their common peaks due to resonance; it is also less sensitive to changes in receiver position. Evaluation of the proposed equalization filter using measured room transfer functions shows that it can reduce the deviations in the frequency characteristics of multiple room transfer functions better than a conventional multiple-point inverse filter. Experiments show that the proposed filter enables 1-5 dB additional amplifier gain in a public address system without acoustic feedback at multiple receiver positions. Furthermore, the proposed filter reduces the reflected sound in room impulse responses without the pre-echo that occurs with a multiple-point inverse filter. A multiple-point equalization filter using common acoustical poles can thus equalize multiple room transfer functions by suppressing their common peaks.
Poultry Colonization with <i>Campylobacter</i> and Its Control at the Primary Production Level (2014)

The handling and consumption of poultry is an important source of human campylobacteriosis. It is widely assumed that the control of Campylobacter in meat-producing poultry, with the aim of reducing the numbers of Campylobacter on poultry meat at the retail level, will reduce the public health burden of human campylobacteriosis. This chapter updates the knowledge of poultry infections and their control at the farm level and extends it to include the interface between the farm and the slaughterhouse. The focus of the chapter remains on the control of Campylobacter in primary production because in this food chain, the gut of living poultry is the only amplification point for Campylobacter. Epidemiological and exposure studies have implicated the handling and consumption of poultry meat as an important source for human campylobacteriosis. Colonization is largely in the ceca and is primarily confined to the intestinal mucous layer over the intestinal crypts of the villi. Reducing human campylobacteriosis is an important public health goal in most industrialized countries. Multispecies farming is a clear risk factor for Campylobacter-positive poultry flocks on the same site. The separation of Campylobacter-positive and -negative flocks and decontamination of the meat from positive flocks is an alternative strategy to reducing the risk of campylobacteriosis in humans. One practical control strategy that can be implemented at the farm-slaughterhouse interface is to separate colonized and noncolonized flocks during processing, and to subsequently treat the meat from Campylobacter-positive flocks.
An Automatic Quartz Crystal Microbalance Immunosensor System for Salmonella Detection (2004)

Quartz crystal microbalance (QCM) immunosensors, due to their low cost and suitabilityfor label-free detection, have found increasing applications in bacterial detection. However, theapplications are exclusively based on manual operations, which are laborious and subject tovariations due to disturbance. In this research, an automatic QCM immunosensor system wasdeveloped for Salmonella detection. The QCM immunosensor was fabricated by immobilizing anti-Salmonella polyclonal antibodies with Protein A method, and then installed on a 70 l flow-throughdetection chamber, which was connected to a peristaltic pump and a multi-position switching valve.The resonant frequency of the QCM sensor was monitored in real time by a CHI 400 EQCMcontrolled by a laptop PC under Windows environment. Both the pump and valve were controlled bya programmable timer. Once simply pressed RUN key on the timer, the sensor system performedSalmonella detection automatically. The same QCM immunosensor could detect 5.7 106, 5.7 107,and 5.7 108 CFU/mL of S. Typhimurium continuously with a frequency response of 4.3-19.6 Hz anda noise level of <1 Hz. The total detection time for each sample was ca. 80 min. The immunosensorwas characterized by high-frequency impedance analysis.
Piezoelectric Effects of Applied Electric Fields on Hydrogen-Bond Interactions: First-Principles Electronic Structure Investigation of Weak Electrostatic Interactions (2013)

The piezoelectric properties of 2-methyl-4-nitroaniline crystals were explored qualitatively and quantitatively using an electrostatically embedded many-body (EE-MB) expansion scheme for the correlation energies of a system of monomers within the crystal. The results demonstrate that hydrogen bonding is an inherently piezoelectric interaction, deforming in response to the electrostatic environment. We obtain piezo-coefficients in excellent agreement with the experimental values. This approach reduces computational cost and reproduces the total resolution of the identity (RI)-Møller-Plesset second-order perturbation theory (RI-MP2) energy for the system to within 1.3 × 10(-5)%. Furthermore, the results suggest novel ways to self-assemble piezoelectric solids and suggest that accurate treatment of hydrogen bonds requires precise electrostatic evaluation. Considering the ubiquity of hydrogen bonds across chemistry, materials, and biology, a new electromechanical view of these interactions is required.
Inbreeding and kinship in Saguenay-Lac-St-Jean: a study of newborn samples 1956–1971 (1992)

Samples of individuals born between 1956 and 1971 proportional to the population size of each parish of Saguenay-Lac-St-Jean (SLSJ) were extracted from a computerized population register. The mean inbreeding and kinship coefficients were calculated for each sample. Our results showed that inbreeding and kinship were unevenly distributed in the SLSJ region. The highest values of inbreeding and kinship were found in Bas-Saguenay, an isolated subregion of SLSJ, and in rural parishes. It was also found that the mean inbreeding and kinship coefficients had higher values in parishes that opened between 1872 and 1901 than those opened earlier or later.
Long-wavelength stimulated emission via cascade laser action in Ho : YLF (1979)

Two cascade laser schemes are demonstrated for Ho3+ in LiYF4. The first involves the 5S2, 5I5, and 5I7 manifolds with laser oscillation at 1.392 and 1.673 μm, and the second involves the 5S2, 5I5, and 5I6 manifolds with laser oscillations at 1.392 and 3.914 μm. The 3.9-μm transition is the longest-wavelength rare-earth laser achieved to date and further the system has attractive engineering practicality. The specificity of excitation inherent in the cascade approach is considered essential in overcoming the adverse multiphonon relaxation processes at long wavelengths.
Classification of Water Molecules in Protein Binding Sites (2007)

Water molecules play a crucial role in mediating the interaction between a ligand and a macromolecular receptor. An understanding of the nature and role of each water molecule in the active site of a protein could greatly increase the efficiency of rational drug design approaches: if the propensity of a water molecule for displacement can be determined, then synthetic effort may be most profitably applied to the design of specific ligands with the displacement of this water molecule in mind. In this paper, a thermodynamic analysis of water molecules in the binding sites of six proteins, each complexed with a number of inhibitors, is presented. Two classes of water molecules were identified: those conserved and not displaced by any of the ligands, and those that are displaced by some ligands. The absolute binding free energies of 54 water molecules were calculated using the double decoupling method, with replica exchange thermodynamic integration in Monte Carlo simulations. It was found that conserved water molecules are on average more tightly bound than displaced water molecules. In addition, Bayesian statistics is used to calculate the probability that a particular water molecule may be displaced by an appropriately designed ligand, given the calculated binding free energy of the water molecule. This approach therefore allows the numerical assessment of whether or not a given water molecule should be targeted for displacement as part of a rational drug design strategy.
Review: <i>Historians Against History: The Frontier Thesis and the National Covenant in American Historical Writing Since 1830</i>, by David W. Noble (1966)

Book Review| September 01 1966 Review: Historians Against History: The Frontier Thesis and the National Covenant in American Historical Writing Since 1830, by David W. Noble Historians Against History: The Frontier Thesis and the National Covenant in American Historical Writing Since 1830David W. Noble Wilbur R. Jacobs Wilbur R. Jacobs Search for other works by this author on: This Site PubMed Google Scholar Southern California Quarterly (1966) 48 (3): 323–324. https://doi.org/10.2307/41170046 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Cite Icon Cite Search Site Citation Wilbur R. Jacobs; Review: Historians Against History: The Frontier Thesis and the National Covenant in American Historical Writing Since 1830, by David W. Noble. Southern California Quarterly 1 September 1966; 48 (3): 323–324. doi: https://doi.org/10.2307/41170046 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentSouthern California Quarterly Search This content is only available via PDF. Copyright, 1966 The Historical Society of Southern California Article PDF first page preview Close Modal You do not currently have access to this content.
Synthesis and curing kinetics of cardanol-based curing agents for epoxy resin by <i>in situ</i> depolymerization of paraformaldehyde (2013)

Three novel cardanol-based phenalkamines with good stability have been successfully prepared by Mannich reaction using phenolic compounds with paraformaldehyde and hexamethylenediamine (or its mixture with other amines). The structure of the prepared phenalkamines has been analyzed using liquid chromatography-mass spectrometry, nuclear magnetic resonance, and Fourier transform infrared spectroscopy. The curing kinetics of the prepared epoxy resin/phenalkamine systems has been investigated using differential scanning calorimetry (DSC), and determined by Kissinger, Flynn–Wall–Ozawa, and Crane methods. Furthermore, the thermal properties of the cured materials have been evaluated using DSC and thermogravimetric analysis, and the mechanical properties of the cured materials have been analyzed systematically. The results demonstrate that the phenalkamine 1 (PAA1) had a lower reactivity and better toughness than phenalkamine 2 (PAA2) and phenalkamine 3 (PAA3). In addition, PAA1 is a solid curing agent, while PAA2 and PAA3 are liquid curing agents, which were more convenient for practical usage. Results indicate that the properties of the prepared phenalkamines strongly depend on the structures. © 2013 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2014, 52, 472–480
Your Sentiment Precedes You: Using an author’s historical tweets to predict sarcasm (2015)

Sarcasm understanding may require information beyond the text itself, as in the case of 'I absolutely love this restaurant!' which may be sarcastic, depending on the contextual situation. We present the first quantitative evidence to show that historical tweets by an author can provide additional context for sarcasm detection. Our sarcasm detection approach uses two components: a contrast-based predictor (that identifies if there is a sentiment contrast within a target tweet), and a historical tweet-based predictor (that identifies if the sentiment expressed towards an entity in the target tweet agrees with sentiment expressed by the author towards that entity in the past).
[Anatomical validation of the size and location of the trephination opening in the surgical treatment of traumatic intracranial hematoma]. (1989)

The internal configuration of the skull in the fronto-parietal-temporal region was examined in 40 victims of extracranial pathology. Among them were 22 brachycephalics, 8 mesocephalics, and 10 dolichocephalics. A flattened part of the vault of the skull was revealed in the parieto-temporal area and its size depended little on the shape of the skull. The size of this part of the skull was measured and found to be 61 X 72 mm in males and 60 X 67 mm in females. The advantage of forming the trephination window within the boundaries of the flattened part of the vault of the skull is shown.
Parallel Discrete‐Event Simulation (2010)

Abstract Parallel discrete‐event simulation (PDES), sometimes simply referred to as parallel simulation , is concerned with the execution of discrete‐event simulation on parallel computers. PDES has been recognized as a challenging field of research bridging modeling and simulation, and high‐performance computing. By exploiting the potential parallelism in a simulation model, PDES can overcome the limitations imposed by sequential simulation, both in the execution time and the memory space. It has been demonstrated to be a viable technique for solving large‐scale complex models. In this article, we provide a brief overview of the current state of PDES, identify its fundamental challenges, and discuss existing principal solutions resulting from three decades of intensive research in this field. Further, we report specific research advances in high‐performance modeling and simulation of large‐scale computer networks as an exemplar of typical PDES applications.
Transferrin receptor 2 is a component of the erythropoietin receptor complex and is required for efficient erythropoiesis (2010)

Erythropoietin (Epo) is required for erythroid progenitor differentiation. Although Epo crosslinking experiments have revealed the presence of Epo receptor (EpoR)-associated proteins that could never be identified, EpoR is considered to be a paradigm for homodimeric cytokine receptors. We purified EpoR-binding partners and identified the type 2 transferrin receptor (TfR2) as a component of the EpoR complex corresponding to proteins previously detected in cross-linking experiments. TfR2 is involved in iron metabolism by regulating hepcidin production in liver cells. We show that TfR2 and EpoR are synchronously coexpressed during the differentiation of erythroid progenitors. TfR2 associates with EpoR in the endoplasmic reticulum and is required for the efficient transport of this receptor to the cell surface. Erythroid progenitors from TfR2(-/-)mice show a decreased sensitivity to Epo and increased circulating Epo levels. In human erythroid progenitors, TfR2 knockdown delays the terminal differentiation. Erythroid cells produce growth differentiation factor-15, a cytokine that suppresses hepatic hepcidin production in certain erythroid diseases such as thalassemia. We show that the production of growth differentiation factor-15 by erythroid cells is dependent on both Epo and TfR2. Taken together, our results show that TfR2 exhibits a non hepatic function as a component of the EpoR complex and is required for efficient erythropoiesis.
Organization of the No. 1 ESS Stored Program (1964)

The stored program of the no. 1 ESS must perform switching functions reliably and promptly. Its design must be economical of memory and execution time, and must accommodate office growth easily. The program is organized so that an interrupt system initiates the input-output programs that must be performed to accurate timing tolerances. The data collected by these input-output programs are passed to the call processing programs which decide what course of action the calls shall follow. The program also assigns an appropriate share of central control time for maintenance and administrative functions. The program is generic in the sense that specific quantities which change from office to office are looked up in tables and are not embedded in the program itself. This article describes the basic program structure and illustrates it with some typical programs.
High gamma-power predicts performance in sensorimotor-rhythm brain–computer interfaces (2012)

Subjects operating a brain-computer interface (BCI) based on sensorimotor rhythms exhibit large variations in performance over the course of an experimental session. Here, we show that high-frequency γ-oscillations, originating in fronto-parietal networks, predict such variations on a trial-to-trial basis. We interpret this finding as empirical support for an influence of attentional networks on BCI performance via modulation of the sensorimotor rhythm.