gebhart/patrepeval huggingface dataset:
Direct-write 3D printing and characterization of a GelMA-based biomaterial for intracorporeal tissue engineering (2020)

We develop and characterize a biomaterial formulation and robotic methods tailored for intracorporeal tissue engineering (TE) via direct-write (DW) 3D printing. Intracorporeal TE is defined as the biofabrication of 3D TE scaffolds inside of a living patient, in a minimally invasive manner. A biomaterial for intracorporeal TE requires to be 3D printable and crosslinkable via mechanisms that are safe to native tissues and feasible at physiological temperature (37 °C). The cell-laden biomaterial (bioink) preparation and bioprinting methods must support cell viability. Additionally, the biomaterial and bioprinting method must enable the spatially accurate intracorporeal 3D delivery of the biomaterial, and the biomaterial must adhere to or integrate into the native tissue. Current biomaterial formulations do not meet all the presumed intracorporeal DW TE requirements. We demonstrate that a specific formulation of gelatin methacryloyl (GelMA)/Laponite<sup>®</sup>/methylcellulose (GLM) biomaterial system can be 3D printed at physiological temperature and crosslinked using visible light to construct 3D TE scaffolds with clinically relevant dimensions and consistent structures. Cell viability of 71%-77% and consistent mechanical properties over 21 d are reported. Rheological modifiers, Laponite<sup>®</sup> and methylcellulose, extend the degradation time of the scaffolds. The DW modality enables the piercing of the soft tissue and over-extrusion of the biomaterial into the tissue, creating a novel interlocking mechanism with soft, hydrated native tissue mimics and animal muscle with a 3.5-4 fold increase in the biomaterial/tissue adhesion strength compared to printing on top of the tissue. The developed GLM biomaterial and robotic interlocking mechanism pave the way towards intracorporeal TE.
Behavioral Modeling of Radio Frequency Transmitters (2009)

The dependence of modern wireless communication systems on the fidelity of
the transmitter has increased the importance of modeling these components.
Behavioral modeling is a commonly used technique to find the input-output
relationship of a system, without the need for the knowledge of the specific
components. There have been many models proposed in the literature, which
has made it difficult to choose models suitable for the application at hand. By
analyzing and categorizing these models depending on the type of distortions
they can describe, it becomes possible to understand their distortion handling
capabilities. Such an analysis led to the design of two new behavioral models,
one customized for power amplifiers and the other for modulators.
Once different models are analyzed, their usefulness is determined in an
experimental setup. Different models have different modeling capabilities.
While some may be able to model any nonlinear function with high accuracy,
others may be capable of modeling at low computational cost. The
accuracy/complexity tradeoff for some commonly-used behavioral models is
analyzed in this thesis.
In Paper [A], a new behavioral model is proposed for power amplifiers
that combines two commonly used modeling techniques. The performance of
this model is shown to be better than the two models it is based on, and issues
in identification are also discussed.
In Paper [B], a new dual-input model is constructed for modulators. This
model has the ability to describe nonlinear imbalance in a modulator. Different
variants of this model are also proposed, to reduce the computational
complexity.
In Paper [C], a detailed analysis on the accuracy/complexity tradeoff for
some commonly-used power amplifier behavioral models is presented. After
finding the computational complexity in floating point operations per sample,
an experimental setup is used to show that among models studied, the generalized
memory polynomial model has the best accuracy/complexity tradeoff.
Integrin expression in normal and out-of-phase endometria (1998)

Integrins have recently been proposed as having a major role in endometrial receptivity. Different patterns of integrin expression have been described during the normal endometrial cycle, and the co-expression of several integrins, mainly alpha1, alpha4 and beta3 has been considered as specific to the 'window of implantation'. In the present study 55 infertile patients underwent two endometrial biopsies during a single menstrual cycle. An early biopsy was done on postovulatory days 6-8, and a late biopsy was performed on postovulatory days 10 to 12. Histological dating as well as immunohistochemical evaluation of alpha1, alpha4, beta1, beta3, beta5, alpha(v)beta3 integrin expression and oestrogen and progesterone receptors were determined in all endometrial biopsies. Oestradiol and progesterone serum concentrations in serum were evaluated on the same days of the endometrial samplings. Nine out of the 55 midluteal biopsies (16.4%) showed out-of-phase endometria, but all biopsies were in phase in the late luteal phase. Differences in integrin expression between in- and out-of-phase biopsies were observed only for alpha(v)beta3 integrin glandular expression during the midluteal phase. Alpha(v)beta3 integrin glandular expression was found in all late luteal phase biopsies. Alpha(v)beta3 expression was closely correlated with histological maturation of the endometrium appearing suddenly at postovulatory day 6-7 and being expressed by all endometria dated as postovulatory day > or = 8, irrespective of midluteal endometrial biopsies being in phase or out of phase. No differences in integrin expression were detected between patients with or without endometriosis or between patients who became spontaneously pregnant and those who did not. In conclusion, further studies are necessary before patterns of integrin expression may offer an alternative to predict uterine receptivity and implantation potential.
Production of lightweight aggregate from incinerator bottom ash and pulverised fuel ash (2004)

Waste incineration is increasingly considered a leading alternative to landfill in many countries due to limited availability of landfill sites and potential adverse environmental effects associated with waste disposal. Incinerator bottom ash (IBA) residues are generated at a rate of approximately 800 kilotonnes per year in the UK and the majority is currently landfilled. The production of lightweight aggregate by sintering mixes of municipal solid waste IBA and pulverised fuel ash (PFA) represents a potentially attractive reuse application for these highvolume waste materials. PFA has been added to IBA to control the sintering behaviour. The effect of adding a carbonaceous material that decomposes during firing to produce controlled levels of porosity has been investigated. Waste activated carbon has been used as a pore former in pellets containing significant quantities of IBA. Two lightweight aggregates were manufactured, a carbon-free and a carbon-containing aggregate, and were characterised in terms of physical, mechanical, mineralogical and microstructural properties. The IBA-derived aggregate performance was assessed in comparison with commercial synthetic aggregate (Lytag) and the results confirmed the feasibility of the production of lightweight aggregate using significant concentrations of the high-volume combustion bottom ashes.
2-Arylpropionic CXC Chemokine Receptor 1 (CXCR1) Ligands as Novel Noncompetitive CXCL8 Inhibitors (2005)

The CXC chemokine CXCL8/IL-8 plays a major role in the activation and recruitment of polymorphonuclear (PMN) cells at inflammatory sites. CXCL8 activates PMNs by binding the seven-transmembrane (7-TM) G-protein-coupled receptors CXC chemokine receptor 1 (CXCR1) and CXC chemokine receptor 2 (CXCR2). (R)-Ketoprofen (1) was previously reported to be a potent and specific noncompetitive inhibitor of CXCL8-induced human PMNs chemotaxis. We report here molecular modeling studies showing a putative interaction site of 1 in the TM region of CXCR1. The binding model was confirmed by alanine scanning mutagenesis and photoaffinity labeling experiments. The molecular model driven medicinal chemistry optimization of 1 led to a new class of potent and specific inhibitors of CXCL8 biological activity. Among these, repertaxin (13) was selected as a clinical candidate drug for prevention of post-ischemia reperfusion injury.
Micro<scp>RNA</scp>‐126 regulates the induction and function of <scp>CD</scp>4<sup>+</sup> Foxp3<sup>+</sup> regulatory T cells through <scp>PI</scp>3K/<scp>AKT</scp> pathway (2013)

Recent evidence showed that limited activation of PI3K/Akt pathway was critical for induction and function sustainment of CD4(+) Foxp3(+) regulatory T cells (Tregs). However, the underlying mechanism remains largely unknown. In this study, we reported that miR-126 was expressed in mouse and human Tregs. Further study showed that silencing of miR-126 using miR-126 antisense oligonucleotides (ASO) could significantly reduce the induction of Tregs in vitro. Furthermore, miR-126 silencing could obviously reduce the expression of Foxp3 on Tregs, which was accompanied by decreased expression of CTLA-4 and GITR, as well as IL-10 and TGF-β, and impair its suppressive function. Mechanistic evidence showed that silencing of miR-126 enhanced the expression of its target p85β and subsequently altered the activation of PI3K/Akt pathway, which was ultimately responsible for reduced induction and suppressive function of Tregs. Finally, we further revealed that miR-126 silencing could impair the suppressive function of Tregs in vivo and endow effectively antitumour effect of CD8(+) T cells in adoptive cell transfer assay using a murine breast cancer model. Therefore, our study showed that miR-126 could act as fine-tuner in regulation of PI3K-Akt pathway transduction in the induction and sustained suppressive function of Tregs and provided a novel insight into the development of therapeutic strategies for promoting T-cell immunity by regulating Tregs through targeting specific miRNAs.
Selective Alkylation of 2-Pyridone in Solvent-Free Conditions (1994)

Abstract Alkylation of 2-pyridone has been performed in solvent-free conditions. The effect of base, phase transfer agent, and alkylation agent has been discussed.
Towards using Unmanned Aerial Vehicles (UAVs) in Wilderness Search and Rescue (2009)

Wilderness Search and Rescue (WiSAR) is the process of finding and assisting persons who are lost in remote wilderness areas. Because such areas are often rugged or relatively inaccessible, searching for missing persons can take huge amounts of time and resources. Camera-equipped mini-Unmanned Aerial Vehicles (UAVs) have the potential for speeding up the search process by enabling searchers to view aerial video of an area of interest while closely coordinating with nearby ground searchers. In this paper, we report on lessons learned by trying to use UAVs to support WiSAR. Our research methodology has relied heavily on field trials involving searches conducted under the direction of practicing search and rescue personnel but using simulated missing persons. Lessons from these field trials include the immediate importance of seeing things well in the video, the field need for defining and supporting various roles in the search team, role-specific needs like supporting systematic search by providing a visualization tool to represent the quality of the search, and the on-going need to better support interactions between ground and video searchers. Surprisingly to us, sophisticated autonomous search patterns were less critical than we anticipated, though advances in video enhancement and visualizing search progress, as well as ongoing work to model the likely location of a missing person, open up the possibility of closing the loop between UAV path-planning, search quality, and the likely location of a moving missing person. Keywords: Unmanned Aerial Vehicles, Wilderness Search and Rescue, Human–Robot Interaction, Human Factors, Field Robotics, Graphical User Interfaces
Studies on the Alkaloids of Menispermaceous Plants. CCXXIV : Syntheses of Dauricine Type Bases. (1) : Synthesis of 2-Hydroxy-5, 4'-bis(2-methyl-6, 7-dimethoxy-1, 2, 3, 4-tetra-hydroisoquinolin-1-ylmethyl)-diphenyl Ether (1966)

dl-Armepavine (VIIIa) and dl-3'-bromo-4'-O-acetylarmepavine (IX) were synthesized and they were submitted to the Ullmann condensation in pyridine, in the presence of potassium carbonate, with copper powder or copper oxide powder as a catalyst, affording the title compound, 2-hydroxy-5, 4'-bis(2-methyl-6, 7-dimethoxy-1, 2, 3, 4-tetrahydroisoquinolin-1-yl-methyl)diphenyl ether (I). Examination of the infrared and NMR spectra of I indicated that I is a diastereoisomeric racemates having the same planar structure as natural dauri-cine (D, D).
Research of Imitating the Thinking Orbit and Revolutionizing China’s English Education (2010)

This essay has done research into some natural rules existing in the human brains ,especially the 0101…rule used as the principle of the computers and existing in the universe .The essay has discussed speech sound and written languge and their relationships with the purpose of choosing the correct orbit to imitae thinking.The essay has concluded that by means of imitating the thinking orbit we can bring about a revolution in studying and teaching English.Finally the essay sincerely suggests that the Chinese governments at all levels collect opinions and wisdom from many Chinese of ideals and integrity, follow the trend of the world languages, assimilate the essence of languages and reject the dross, and adopt the methods of imitating thinking to popularize English among the Chinese people by bringing the united efforts of the country into play. Key words: natural rules, imitate, thinking orbit, revolutionizing Resume: L’essai a recherche quelques regles naturelles existant dans les cerveaux, surtout la 0101…regle existant dans les ordinateurs, les cerveaux humains, et dans l’univers. L’essai s’est concentre sur trios orbites:l’ orbite sonore, l’orbite des caracteres ,et l’orbite du mode de pensee dans les cerveau. L’essai a conclu que etudier et enseigner l’anglais a l’aide de l’orbite de simulation, nous pouvons apporter une revolution dans l’enseignement de l’anglais et promouvoir considerablement la popularisation de l’anglais. Mots-Cles: regles naturelles, imiter, orbite pensante, revolutionner
Cambios bioquímicos en el tejido cavernoso causados por resección unilateral del nervio cavernoso y efectos del ácido alfalipoico en estos cambios (2010)

Nervio cavernoso
Clinical efficacy and toxicity of doxorubicin encapsulated in glutaraldehyde-treated erythrocytes administered to dogs with lymphosarcoma (1994)

Doxorubicin was encapsulated in canine erythrocytes, treated with 0.32% glutaraldehyde, and administered at a dosage equivalent to 30 mg of free doxorubicin/m2 of body surface area to dogs with diagnosis of lymphosarcoma. Compared with administration of free doxorubicin, this method of drug delivery substantially reduced peak plasma concentration and prolonged higher plasma concentration of doxorubicin. As such, this method was comparable to continuous IV infusion. Previous studies have indicated this method's potential for reduction in toxic side effects, particularly cardiotoxicosis, while allowing higher total doses of doxorubicin to be administered. In this study, doxorubicin encapsulated in glutaraldehyde-treated erythrocytes induced a triphasic exponential decay of doxorubicin from plasma, the highest relative contribution to the total area of the curve being the terminal phase. The treatment was effective in inducing complete and partial remissions of lymphosarcoma, with minimal acute toxicosis and no evidence of cardiotoxicosis. However, substantial, unanticipated, chronic, nonregenerative myelosuppression developed, and was mot strikingly expressed as profound thrombocytopenia. Efforts to ameliorate or circumvent this toxic effect will be required prior to further consideration of this doxorubicin delivery system for treatment of systemic neoplasia.
An efficient and low power systolic squarer (2005)

Squarer has been extensively applied on image, video and data compression for portable devices. Thus, squarer with faster speed, smaller die size, and lower power is tremendously important practically. By carefully classifying the cells in straightforward systolic array into 5 groups and carefully design each cell by reducing the gate count of full adder and D flip flops, we proposed a new systolic squarer that outperforms the other circuits (Chun-Lung Shu and Wu-Hung Lu, 2003; Kolagotla et al., 1998; Dumonteix et al., 2001) on number of transistors, speed, power, and power/speed ratio. The design has been implemented on chip using TSMC 0.35 /spl mu/m 2P4M process.
[An increased sensitivity of the mitochondrial permeability transition pore to calcium in the heart of rats with chronic deficiency of nigrostriatal dopamine]. (2009)

We studied the sensitivity of mitochondrial permeability transition pore (MPTP) opening to natural inductors--Ca2+ ions in the rat heart mitochondria with chronic deficiency of nigrostriatal dopamine caused by an injection of selective neurotoxin 6-hydroxidofamine in an ascending lateral bundle of the forebrain. MPTP-opening was determined specrophotometrically (lamda=520 nm) by a decrease in an optical density resulting from mitochondrial swelling. It has been shown that the rat heart mitochondria with chronic deficiency of nigrostriatal dopamine are more sensitive to Ca2+ in its physiological concentration (10(-7) mol/l) and overload (10(-6) - 10(-4) mol/l) in comparison to control animals. Thus, obtained results lead to a conclusion that an increased sensitivity of the mitochondrial permeability transition pore to calcium and mitochondrial membrane permeability may be one of the causes previously reported of disturbance in contractile function of the rat heart with chronic deficiency of nigrostriatal dopamine.
Privacy-Preserving Queries over Secret-Shared Graph-Structured Data (2017)

We investigate the use of the SPDZ multiparty computation platform to facilitate secure cloud storage of graph-structured data such as telecommunications metadata. We report on an implementation of a simple scheme for answering adjacency, nearest-neighbour and second-hop queries. Our solution hides the data, the query and the answer from the cloud servers unless they all collude to recover them.
Loss of normal thymic repertoire selection and persistence of autoreactive T cells in graft vs host disease. (1994)

To assess the influence of graft vs host disease (GVHD) on T cell development and thymic repertoire selection, a murine transplantation model was chosen, in which donor (B10.BR: Mls-1b, Mls-2b) and recipient (CBA/J: Mls-1a, Mls-2a) mice differ in their minor lymphocyte-stimulating Ag. Mature splenic T cells of donor origin were added to the T cell-depleted bone marrow cells to induce moderate GVHD. When analyzed 5 and 10 wk after transplantation, animals with GVHD, but not disease-free controls, demonstrated aberrant thymic maturation with an increase in single positive, TCRhigh+ thymocytes. Phenotypic analysis of TCR V beta expression in mature thymocytes and peripheral T cells revealed a disruption of negative thymic selection of Mls-reactive T cells with the subsequent emergence of V beta 3+ and V beta 6+ T cells in mice with GVHD but not in controls. Using retroviral-mediated gene transfer to tag mature T cells, these V beta 3+ and V beta 6+ T cells could be shown to be derived from donor bone marrow precursors. Thymocytes expressing V beta 3 and V beta 6 were efficiently activated upon cross-linking of their TCRs and peripheral T cells from mice with GVHD proliferated to host-derived splenocytes in a MLR. When transferred to sublethally irradiated CBA/J recipients, only T cells from mice with GVHD expanded dramatically. These data suggest that the lack of proper thymic selection after bone marrow transplantation results in the survival and persistence of self-reactive T cells, which might be responsible for the autoimmune manifestations of chronic GVHD.
Differential impact of telomere dysfunction on initiation and progression of hepatocellular carcinoma. (2003)

Telomere maintenance and telomerase reactivation are near universal features of human hepatocellular carcinoma (HCC), yet the shorter telomeres and highly abnormal cytogenetic profiles of HCC suggest that telomere erosion and dysfunction may be operative during the formative stages of tumorigenesis. Previous studies have established that the cancer-enhancing or suppressing impact of telomere dysfunction is highly dependent on several parameters including cell type, tumor stage, and p53 status. Here, to understand better the pathogenetic role of telomere dysfunction in the initiation and progression in human HCC, we have used three mechanistically distinct liver cancer-prone model systems (urokinase plasminogen activator transgenic mice, carbon tetrachloride exposure, and diethylnistrosamine treatment) in the context of successive generations of telomerase-deficient mice null for the telomerase RNA component, mTERC. Across all of the HCC model systems, telomere dysfunction suppressed both the incidence and growth of HCC lesions, a trend that mirrored the level of intratumoral proliferative arrest and apoptosis. On the histological level, telomere dysfunction was associated with a significant increase in the number of early stage neoplastic lesions and a reciprocal decline in the occurrence of high-grade malignancies. These genetic data in the mouse indicate that telomere dysfunction exerts an opposing role in the initiation versus progression of HCC and provide a framework for understanding the intimate link among chronic liver disease, chromosomal instability, and increased HCC in humans.
Transforming feedback - a study of how interactive, engagement-oriented feedback can enhance behaviour change around electricity consumption (2014)

The ‘Transforming Feedback’ pilot study aimed to explore the impacts of a form of feedback that was designed to engage users in the process of interpreting and re-visualising data about their home electricity consumption. This report describes the aims and methods of the study and outlines the system used to engage people with feedback about their consumption. The study was conducted between August 2013 and February 2014. The paragraphs below discuss some of the implementation of the research design and list the main themes that have so far emerged from the data analysis. \n\nFor a period of three weeks, twelve households were provided with equipment that measured the electricity consumption of their household and were asked to spend 5-10 minutes each day using an online software application that enabled them to view how their consumption varied minute by minute, label that consumption according to the activities or devices associated with it and test out different visualisations of the resulting information set. Following the three-week trial, participants were interviewed about their experiences and an analysis made of the digital trace left by their interactions with it.