gebhart/patrepeval huggingface dataset:
Controllably releasing long-lived quantum memory for photonic polarization qubit into multiple spatially-separate photonic channels (2016)

We report an experiment in which long-lived quantum memories for photonic polarization qubits (PPQs) are controllably released into any one of multiple spatially-separate channels. The PPQs are implemented with an arbitrarily-polarized coherent signal light pulses at the single-photon level and are stored in cold atoms by means of electromagnetic-induced-transparency scheme. Reading laser pulses propagating along the direction at a small angle relative to quantum axis are applied to release the stored PPQs into an output channel. By changing the propagating directions of the read laser beam, we controllably release the retrieved PPQs into 7 different photonic output channels, respectively. At a storage time of δt = 5 μs, the least quantum-process fidelity in 7 different output channels is ~89%. At one of the output channels, the measured maximum quantum-process fidelity for the PPQs is 94.2% at storage time of δt = 0.85 ms. At storage time of 6 ms, the quantum-process fidelity is still beyond the bound of 78% to violate the Bell's inequality. The demonstrated controllable release of the stored PPQs may extend the capabilities of the quantum information storage technique.
The effect of angiotensin II on blood flow in tumours during localized hyperthermia (1989)

The selective enhancement of drug delivery to tumours is an important factor in the effectiveness of thermochemotherapy as well as in standard normothermal chemotherapy. We have attempted to clarify experimentally using AH 100B tumour-bearing rats whether or not a selective increase in blood flow in tumours can be produced under specific conditions of local hyperthermia by administration of angiotensin (AGT II). AGT II (2 micrograms/kg/min) produced an elevation of blood pressure (ca. 150 mm Hg) when local hyperthermia, at 41, 43, and 45 degrees C, was induced. Furthermore, at 41 and 43 degrees C a selective increase in blood flow in tumours resulted from the AGT II-induced hypertension. By contrast, a decrease in blood flow was observed at 45 degrees C both in tumour and in muscle. These results indicate that AGT II-induced hypertension and the resultant selective increase in drug delivery to tumours during the initial phase of heating may result in an augmentation of the anticancer effects of thermochemotherapy.
Selective alginate degradation by marine bacteria associated with the algal genusSargassum (1986)

Alginase-secreting bacteria associated with actively growing tissues of the marine Phaeophyta speciesSargassum fluitans andS. natans have been isolated and evaluated for their ability to degrade alginate (ALG), carboxymethylcellulose, and agar. Of seven isolates selected for their ability to grow on 2% agar containing 1% sodium alginate, none were able to grow on either 2% agar or 2% agar supplemented with 0.1% carboxymethylcellulose. Two of these with fermentative potential, i.e., ALG-A and ALG-G, showed selective activities with respect to their ability to degrade native alginate and/or take up the products resulting from alginate degradation. The ALG-A isolate was able to rapidly degrade native alginate with the generation of a stable polymer fraction and small oligouronides, most of which were dissimilated for growth. The ALG-G isolate was able to completely degrade native alginate with the accumulation of significant quantities of unsaturated dimeric and trimeric oligouronides. A limit polymer was generated from the action of a polymannuronan-specific extracellular alginate lyase purified from exponential cultures of the ALG-A organism. This product proved to be an effective substrate for the alginate lyase activity obtained from the medium of exponential phase cultures of the ALG-G isolate, and upon incubation with concentrated and dialyzed ALG-G medium was converted to the products that were observed to accumulate in the medium of the ALG-G isolate grown on native alginate. These organisms represent examples of the microflora associated with actively growingSargassum tissues, each with a selective ability to degrade and dissimilate the biomass of the marine brown algae.
Artificial Neural Network for Probabilistic Feature Recognition in Liquid Chromatography Coupled to High-Resolution Mass Spectrometry (2016)

In this work, a novel probabilistic untargeted feature detection algorithm for liquid chromatography coupled to high-resolution mass spectrometry (LC-HRMS) using artificial neural network (ANN) is presented. The feature detection process is approached as a pattern recognition problem, and thus, ANN was utilized as an efficient feature recognition tool. Unlike most existing feature detection algorithms, with this approach, any suspected chromatographic profile (i.e., shape of a peak) can easily be incorporated by training the network, avoiding the need to perform computationally expensive regression methods with specific mathematical models. In addition, with this method, we have shown that the high-resolution raw data can be fully utilized without applying any arbitrary thresholds or data reduction, therefore improving the sensitivity of the method for compound identification purposes. Furthermore, opposed to existing deterministic (binary) approaches, this method rather estimates the probability of a feature being present/absent at a given point of interest, thus giving chance for all data points to be propagated down the data analysis pipeline, weighed with their probability. The algorithm was tested with data sets generated from spiked samples in forensic and food safety context and has shown promising results by detecting features for all compounds in a computationally reasonable time.
Fluorescent protein barrel fluctuations and oxygen diffusion pathways in mCherry (2011)

Fluorescent proteins (FPs) are valuable tools as biochemical markers for studying cellular processes. Red fluorescent proteins (RFPs) are highly desirable for in vivo applications because they absorb and emit light in the red region of the spectrum where cellular autofluorescence is low. The naturally occurring fluorescent proteins with emission peaks in this region of the spectrum occur in dimeric or tetrameric forms. The development of mutant monomeric variants of RFPs has resulted in several novel FPs known as mFruits. Though oxygen is required for maturation of the chromophore, it is known that photobleaching of FPs is oxygen sensitive, and oxygen-free conditions result in improved photostabilities. Therefore, understanding oxygen diffusion pathways in FPs is important for both photostabilites and maturation of the chromophores. In this paper, we use molecular dynamics calculations to investigate the protein barrel fluctuations in mCherry, which is one of the most useful monomeric mFruit variant. We employ implicit ligand sampling to determine oxygen pathways from the bulk solvent into the mCherry chromophore in the interior of the protein. We also show that these pathways can be blocked or altered and barrel fluctuations can be reduced by strategic amino acid substitutions.
Adverse Drug Events: Database Construction and in Silico Prediction (2013)

Adverse drug events (ADEs) are the harms associated with uses of given medications at normal dosages, which are crucial for a drug to be approved in clinical use or continue to stay on the market. Many ADEs are not identified in trials until the drug is approved for clinical use, which results in adverse morbidity and mortality. To date, millions of ADEs have been reported around the world. Methods to avoid or reduce ADEs are an important issue for drug discovery and development. Here, we reported a comprehensive database of adverse drug events (namely MetaADEDB), which included more than 520,000 drug-ADE associations among 3059 unique compounds (including 1330 drugs) and 13,200 ADE items by data integration and text mining. All compounds and ADEs were annotated with the most commonly used concepts defined in Medical Subject Headings (MeSH). Meanwhile, a computational method, namely the phenotypic network inference model (PNIM), was developed for prediction of potential ADEs based on the database. The area under the receive operating characteristic curve (AUC) is more than 0.9 by 10-fold cross validation, while the AUC value was 0.912 for an external validation set extracted from the US-FDA Adverse Events Reporting System, which indicated that the prediction capability of the method was reliable. MetaADEDB is accessible free of charge at http://www.lmmd.org/online_services/metaadedb/. The database and the method provide us a useful tool to search for known side effects or predict potential side effects for a given drug or compound.
TAR-independent replication of human immunodeficiency virus type 1 in glial cells (1992)

The molecular mechanisms involved in the replication of human immunodeficiency virus type 1 (HIV-1) may differ in various cell types and with various exogenous stimuli. Astrocytic glial cells, which can support HIV-1 replication in cell cultures and may be infected in vivo, are demonstrated to provide a cellular milieu in which TAR mutant HIV-1 viruses may replicate. Using transfections of various TAR mutant HIV-1 proviral constructs, we demonstrate TAR-independent replication in unstimulated astrocytic cells. We further demonstrate, using viral constructs with mutations in the tat gene and in the nuclear factor kappa B (NF-kappa B)-binding sites (enhancer) of the HIV-1 long terminal repeat, that TAR-independent HIV-1 replication in astrocytic cells requires both intact NF-kappa B moiety-binding motifs in the HIV-1 long terminal repeat and Tat expression. We measured HIV-1 p24 antigen production, syncytium formation, and levels and patterns of viral RNA expression by Northern (RNA) blotting to characterize TAR-independent HIV-1 expression in astrocytic glial cells. This alternative regulatory pathway of TAR-independent, Tat-responsive viral production may be important in certain cell types for therapies which seek to perturb Tat-TAR binding as a strategy to interrupt the viral lytic cycle.
CD158k/KIR3DL2 is a useful marker for identifying neoplastic T‐cells in Sézary syndrome by flow cytometry (2007)

Enumeration of neoplastic T-cells in peripheral blood specimens is necessary for the diagnosis of Sézary syndrome (SS) and monitoring treatment responses. Because neoplastic T-cells in SS can be difficult to identify by morphology alone, flow cytometry immunophenotyping is often utilized. However, the reported immunophenotypic criteria for identifying neoplastic T-cells in SS are variable, not present in all cases, or sometimes found in reactive T-cell populations. Peripheral blood lymphocytes from 33 cases of SS were evaluated for the expression of pan-T cell antigens and killer cell immunoglobulin-like MHC receptors (KIR) CD158a, CD158b, CD158e, CD158i, and CD158k by multiparameter flow cytometry using monoclonal antibodies EB6, GL183, FES172, Z27, and Q66. A variety of abnormalities related to expression of pan-T-cell antigens typical of neoplastic T-cells were observed. Expression of CD158k was observed in 32/33 cases and restricted to the phenotypically abnormal T-cell populations, while expression of other KIR was mostly negative. Our findings confirm and extend recent reports by one group that CD158k is expressed by most SS cases. Moreover, our observation that CD4 positive, CD7 negative T-cells are mostly CD158k negative further suggests that CD158k may be able to help identify and enumerate neoplastic T-cells in SS even when present at low levels.
Layer 1 virtual private networks: service concepts, architecture requirements, and related advances in standardization (2004)

This article describes service concepts, service requirements, and high-level network architecture requirements for layer 1 virtual private network service. It takes in consideration progress achieved in standardization, mainly inside ITU-T SG 13, which has been very active in this area.
Unpredictable random number generator based on mobile sensors (2011)

Cryptographic applications need quality random number generators for reaching a high level of security. As the industry is moving forward at a high pace and the mobile paradigm emerging, new sources of randomness arise. One of them is the new generation of phones, also known as smartphones. We propose an unpredictable random number generator, which, using the hardware sensors of a modern phone, is able to produce high quality sequences of random bits.
Antioxidant Properties of Ethyl Vanillin<i>in Vitro</i>and<i>in Vivo</i> (2011)

We systematically evaluated the antioxidant activity of ethyl vanillin, a vanillin analog, as compared with the activities of vanillin and other vanillin analogs using multiple assay systems. Ethyl vanillin and vanillin exerted stronger antioxidant effects than did vanillyl alcohol or vanillic acid in the oxygen radical absorbance capacity (ORAC) assay, although the antioxidant activities of vanillyl alcohol and vanillic acid were clearly superior to those of ethyl vanillin and vanillin in the three model radical assays. The antioxidant activity of ethyl vanillin was much stronger than that of vanillin in the oxidative hemolysis inhibition assay, but was the same as that of vanillin in the ORAC assay. Oral administration of ethyl vanillin to mice increased the concentration of ethyl vanillic acid, and effectively raised antioxidant activity in the plasma as compared to the effect of vanillin. These data suggest that the antioxidant activity of ethyl vanillin might be more beneficial than has been thought in daily health practice.
Single Point Diamond Turning Effects on Surface Quality and Subsurface Damage in Ceramics (2009)

Advanced ceramics, such as Silicon Carbide (SiC) and Quartz, are increasingly being used for industrial applications. These ceramics are hard, strong, inert, and light weight. This combination of properties makes them ideal candidates for tribological, semiconductor, MEMS and optoelectronic applications respectively. Manufacturing these materials without causing surface and subsurface damage is extremely challenging due to their high hardness, brittle characteristics and poor machinability. Often times, severe fracture can result when trying to achieve high material removal rates during machining of SiC or quartz due to their low fracture toughness. This research demonstrates that ductile regime Single Point Diamond Turning (SPDT) is possible on these materials to improve its surface quality without imparting subsurface damage. Machining parameters, such as depth of cut and feed, used to carry out ductile regime machining will be discussed. Subsurface damage analysis was carried out on the machined samples using non-destructive methods such as Optical Microscopy, Raman Spectroscopy and Scanning Acoustic Microscopy to show evidence that the chosen material removal method leaves a damage-free surface and subsurface. Optical microscopy was used to image the improvements in surface finish whereas Raman spectroscopy and scanning acoustic microscopy was used to observe the formation of amorphous layer and subsurface imaging in the machined regions. All three techniques complement the initial hypothesis of being able to remove a nominally brittle material in the ductile regime.
Mechanical relaxation processes in polyether block amide copolymers (PEBA) (1989)

Abstract Dynamic mechanical experiments were carried out on a series of polyether block amide copolymers based on poly(tetramethylene oxide) and polyamide 12 with varying PE/PA weight ratio. Internal friction spectra exhibited three main peaks related to the subglass transition of the soft segments, the glass transition of the soft segments and the glass transition of the hard segments, respectively. Moreover, the effect of thermal history on dynamic mechanical behaviour of a particular PEBA sample (70% PA wt) is investigated.
Medical management of acute and chronic vomiting in dogs and cats (2010)

Vomiting is a common presentation in small animal practice and can be associated with a wide variety of both gastrointestinal and systemic diseases. A logical diagnostic approach is required to identify the underlying cause to ensure that appropriate therapy can be instituted. Medical management of vomiting can involve drug therapy, fluid therapy and dietary manipulation. This article describes the physiology and pharmacological control of acute and chronic vomiting in dogs and cats.
A tale that fiction would envy: Naturalistic inquiry methods in the visual arts (2002)

This paper reports on the range of ethnographic research methods that are currently being applied in the author's investigation of a number of artists who teach in tertiary institutions. The study examines the relation between the artistic practice and the teaching practice of the artist/academic respondents to the study. In particular this paper cites a form of semantic analysis that seeks triangulated endorsement for its claims through the use of a combination of unstructured and structured interviews, unobtrusive observation and documentary evidence.
Polymerization. VI. The Alfin Catalysts<sup>1a</sup> (1947)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPolymerization. VI. The Alfin Catalysts1aAvery A. Morton, Eugene E. Magat, and Robert L. LetsingerCite this: J. Am. Chem. Soc. 1947, 69, 4, 950–961Publication Date (Print):April 1, 1947Publication History Published online1 May 2002Published inissue 1 April 1947https://pubs.acs.org/doi/10.1021/ja01196a067https://doi.org/10.1021/ja01196a067research-articleACS PublicationsRequest reuse permissionsArticle Views149Altmetric-Citations38LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Hemofiltration Reverses Left Ventricular Dysfunction during Sepsis in Dogs (1990)

Depressed left ventricular (LV) contractility in sepsis has been ascribed to the presence of circulating cardiodepressant substance (filterable cardiodepressant factor in sepsis [FCS]); however, this finding is controversial. The authors hypothesized that if a decrease in LV contractility indeed occurred due to a circulating depressant substance, then removal of this substance by hemofiltration would reverse by dysfunction. In this study, LV mechanics were examined before and after hemofiltration in anesthetized dogs during continuous intravenous infusion of live Escherichia coli. Left ventricular anterior-posterior and apex-base dimensions were measured by subendocardial ultrasonic crystal transducers implanted 4 weeks before the experiments. Left ventricular contractility was determined from the end-systolic pressure-dimension relationship. The slope of this relationship (Emax) is an index of contractility. After 4 h of sepsis, Emax was reduced by one half. Hemofiltration resulted in a return of Emax to control values. The FCS activity in the plasma was also assessed by the percent reduction in isometric contraction of electrically stimulated, isolated right ventricular trabeculae obtained from nonseptic dogs. The FCS activity reached a peak 4 h after sepsis and was reduced after 2 h of hemofiltration. The results show that during experimental sepsis, a circulating substance of less than 30,000 d produces a decrease in LV contractility and that this LV dysfunction may be improved by hemofiltration.
BST-236, a novel cytarabine prodrug for patients with acute leukemia unfit for standard induction: a phase 1/2a study (2019)

High-dose cytarabine is the backbone of acute myeloid leukemia (AML) treatment. Nevertheless, its use in older patients is considerably limited due to increased toxicity. BST-236 (INN aspacytarabine) is a novel cytarabine prodrug designed to deliver high-dose cytarabine to target cells with reduced systemic exposure to free cytarabine. This phase 1/2a dose-escalation study was designed to evaluate BST-236 safety, pharmacokinetics, and efficacy in older or unfit-for-intensive-therapy patients with acute leukemia. Twenty-six patients, unfit for standard therapy, who were either relapsed/refractory or newly diagnosed, received BST-236 in 6 dose-escalating cohorts (range 0.3 to 6 g/m2 per day). BST-236 was administered intravenously once daily over 60 minutes for 6 consecutive days. The median age was 76.5 (26 to 90), with 84.6% of patients ≥70 years. BST-236 was safe and well tolerated. The maximal tolerated dose was 6 g/m2 per day. Overall response rate was 29.6%. A subgroup analysis of newly diagnosed patients with AML, de novo or secondary to myelodysplastic syndrome, unfit for standard induction (median age 78), demonstrated overall response of 45.5%. The median overall survival was 6.5 months and was not reached in patients achieving complete remission. The findings of this phase 1/2 study suggest that BST-236 safely delivers high and efficacious cytarabine doses to older patients who are unfit for standard induction and lays the foundation for further studies of BST-236 in AML. This trial was registered at www.clinicaltrials.gov as #NCT02544438.
Improving the Notch-Rupture Strength of Low-Expansion Superalloys (1980)

iron-nickel-cobalt alloys that combine high strength with controlled thermal-expansion characteristics have attractive properties for various applications at temperatures to
Protein profiles in human ovarian cancer cell lines correspond to their metabolic activity and to metabolic profiles of respective tumor xenografts (2012)

Many solid tumors show a large variability in glycolytic activity and lactate accumulation, which has been correlated with different metastatic spread, radioresistance and patient survival. To investigate potential differences in protein profiles underlying these metabolic variances, the highly glycolytic human ovarian cancer cell line OC316 was investigated and compared with the less glycolytic line IGROV-1. Extracellular acidification and oxygen consumption were analyzed with an extracellular flux analyzer. Glycolysis-associated proteins, including specific membrane transporters, were quantified through in-cell western analyses. Metabolic properties of corresponding tumor xenografts were assessed via induced metabolic bioluminescence imaging. Extracellular flux analyses revealed elevated bioenergetics of OC316 cells. Hexokinase II, pyruvate kinase, pyruvate dehydrogenase E1 beta subunit and pyruvate dehydrogenase kinase 1, as well as the glucose transporter 1 and the monocarboxylate transporter 4, were overexpressed in these cells compared with IGROV-1. When generating tumor xenografts in SCID mice, cells maintained their glycolytic behavior, i.e. OC316 showed higher lactate concentrations than IGROV-1 tumors. In summary, a congruency between protein profiles and metabolic properties has been demonstrated in the human ovarian cancer lines investigated. Also, a perpetuation of glycolytic characteristics during the transition from in vitro to the in vivo situation has been documented. This model system could be useful for systematic studies on therapeutic intervention by manipulation of tumor glycolysis and associated pathways.