gebhart/patrepeval huggingface dataset:
Sympathetic Nervous System Blocking Agents. Derivatives of Guanidine and Related Compounds<sup>1</sup> (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSympathetic Nervous System Blocking Agents. Derivatives of Guanidine and Related Compounds1James H. Short, Ursula Biermacher, Daniel A. Dunnigan, and Thomas D. LethCite this: J. Med. Chem. 1963, 6, 3, 275–283Publication Date (Print):May 1, 1963Publication History Published online1 May 2002Published inissue 1 May 1963https://pubs.acs.org/doi/10.1021/jm00339a013https://doi.org/10.1021/jm00339a013research-articleACS PublicationsRequest reuse permissionsArticle Views600Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Comparative Base Specificity, Stability, and Lectin Activity of Two Lectins from Eggs of Rana catesbeiana and R. japonica and Liver Ribonuclease from R. catesbeiana (1991)

Two lectins with RNase activity obtained from eggs of Rana catesbeiana and R. japonica and RNase obtained from R. catesbeiana liver show 65-83% protein homology. The base specificity of these frog proteins was studied with 8 dinucleoside phosphates as substrates and 8 nucleotides as inhibitors. The base specificities of the B1 and B2 sites of these proteins are U greater than C and G greater than U greater than A, C, respectively. The three frog proteins are more resistant than RNase A to heat treatment, guanidine-HCl and pH-induced denaturation; i.e., they retain their native conformation up to at least 70 degrees C at pH 7.5. Differences in stability and base specificity among RNase A and the three frog proteins are discussed in relation to the primary structures. Although the two lectins agglutinate tumor cells (e.g., Ehrlich, S-180 and AH109A ascites carcinoma cells), the liver RNase has no such activity. Agglutination of AH109A cells by the two lectins is inhibited by nucleotides. Our results indicate that the agglutination sites are not identical with, but are related to, the active sites of the three frog proteins.
Preparation of single-crystalline platinum nanowires with small diameters under mild conditions (2006)

We report a convenient method to synthesize single-crystalline platinum nanowires with high aspect ratio of ca. 2.0 nm diameter by sophisticated and precise control of Pt(0) nuclei and their growth.
Microstructure Evolution and Mechanical Properties of 5052 Alloy with Gradient Structures (2021)

This chapter reports on the microstructure evolution and mechanical properties of 5052 Al alloy processed by rotationally accelerated shot peening (RASP). RASP-processed samples at various depths were characterized using cross-sectional transmission electron microscopy observations to reveal the microstructural characteristics at different levels of strain and strain rate, and thereby to uncover the underlying grain refinement mechanism. Systematic TEM observations showed that the critical sizes of subgrain/grain vary with the depth from the surface. Microstructure evolution and grain refinement in 5052 Al alloy induced by RASP were investigated systematically. The effect of RASP treatment on the mechanical properties of 5052 Al alloy sample is also studied. A deformation layer of 2 mm was formed by RASP treatment, indicating the effectiveness and high energy of RASP process. Different dislocation configurations, elongated subgrains, equiaxed subgrains and nano-sized grains were found along the depth from the sample surface. Dynamic recrystallization was primarily responsible for the nano-grain formation.
Digital beamforming in sar systems (2003)

The rapid progression in digital hardware and signal processing capabilities stimulates the development of radar systems. The tendency is to move the digital interface toward the antenna, replacing, whenever possible, analog RF-hardware. Based on software codes, these digital systems are more flexible and easier to reconfigure than RF-hardware. This letter illustrates the general concept for digital beamforming (DBF) in synthetic aperture radar systems and investigates their principle capabilities, limitations, and performance parameters. It is shown that using DBF a simultaneous improvement in azimuth coverage and resolution can be achieved.
Professional Ethics among Criminal Lawyers (1959)

Professional Ethics Among Criminal Lawyers Get access Arthur Lewis Wood Arthur Lewis Wood University of Connecticut Search for other works by this author on: Oxford Academic PubMed Google Scholar Social Problems, Volume 7, Issue 1, Summer 1959, Pages 70–83, https://doi.org/10.2307/798762 Published: 09 August 2014
Engineering cellular trafficking via glycosyltransferase‐programmed stereosubstitution (2012)

The proximate hurdle for cell trafficking to any anatomic site is the initial attachment of circulating cells to target tissue endothelium with sufficient strength to overcome prevailing forces of blood flow. E-selectin, an endothelial molecule that is inducibly expressed at all sites of inflammation, is a potent effector of this primary braking process. This molecule is a member of a family of C-type lectins known as selectins that bind sialofucosylated glycans displayed on either a protein (i.e., glycoprotein) or lipid (i.e., glycolipid) scaffold. On human cells, the predominant E-selectin ligand is a specialized glycoform of CD44 known as hematopoietic cell E-/L-selectin ligand (HCELL). This review focuses on the biology of HCELL/E-selectin interactions in cell migration, and discusses the utility and applicability of glycosyltransferase-programmed stereosubstitution (GPS) for glycoengineering HCELL expression. Without compromising cell viability or native phenotype, this exoglycosylation technology literally "sweetens" CD44, licensing E-selectin-dependent vascular delivery for all cell-based therapeutics.
Bioinspired and biomimetic self-healing of advanced composite materials (2008)

INTRODUCTION Conceptual inspiration from nature is not new, and many engineering approaches can be considered to have been inspired by observing natural systems. The healing potential and repair strategies of living organisms is increasingly of interest to designers seeking lower mass structures with increased service life who wish to progress from a conventional damage tolerance philosophy. Naturally occurring ‘materials’ have evolved into highly sophisticated, integrated, hierarchical structures that commonly exhibit multifunctional behaviour [1]. Inspiration and mimicry of these microstructures and micromechanisms offers considerable potential in the design and improvement of material performance [2] but many of the biological processes involved are extremely complex. Bioinspired self-healing using hollow fibres embedded within a structure has been investigated at different length scales in several materials by various authors, e.g. bulk concrete [3-5] bulk polymers [2, 6], and polymer composites[7-10]. The latter has seen exciting developments in recent years, for example [1119], using the inspiration of biological self-healing applied with broadly traditional engineering approaches. Hollow glass fibres [20, 21] are used in preference to embedded microcapsules [22, 23] because they offer the advantage of being able to store functional agents for self-repair as well as integrating easily with and acting as reinforcement.
Plasmonic Lens Made of Multiple Concentric Metallic Rings under Radially Polarized Illumination (2009)

Optimal plasmonic focusing can be achieved through matching the rotational symmetry of the plasmonic lens to the polarization symmetry of a radially polarized illumination. In this letter, we report the experimental confirmation of the focusing properties and field enhancement effect of plasmonic lens made of multiple concentric annular rings using a collection mode near field scanning optical microscope. Surface plasmons excited at all azimuthal directions propagate toward the geometric center and constructively interfere at the focus to create a strongly enhanced evanescent optical "needle" field that is substantially polarized vertically to the plasmonic lens surface. The field enhancement factor can be improved through adding more rings while maintaining the plasmonic focal spot size. Strategy for optimizing the field enhancement factor is studied with both analytical and numerical methods.
Pregnenolone Sulphate- and Cholesterol-Regulated TRPM3 Channels Coupled to Vascular Smooth Muscle Secretion and Contraction (2010)

The data suggest functional relevance of TRPM3 in contractile and proliferating phenotypes of vascular smooth muscle cells, significance of constitutive channel activity, regulation by cholesterol, and potential value of pregnenolone sulfate in therapeutic vascular modulation.
Deep-UV Photolithography (1978)

Methacrylates PMMA, P(MMA-MA)and FBM can be satisfactorily used as photoresist. FBM has the sensitivity 7 times higher than the PMMA standard developing system. PGMA and P(GMA-EA) have the positive working behaviors. The chrome-on-quartz substrate mask is suitable as a photomask. A Xe–Hg short arc lamp and a Hg long arc lamp are excellent deep-uv sources. Using a collimated exposure system with the 110 mm beam diameter composed of a 600 W Xe–Hg arc lamp, an ellipsoidal reflector and an optical integrator, the required expousre time for PMMA with 1 µm thickness is about 1.5 min. High quality submicron patterns having an aspect ratio of 5 can be replicated on PMMA and P(MMA-MA) by contact printing. A pattern consisting of 1 µm lines is printed on FBM 0.8 µm thick. In the proximity printing, high quality 2 µm patterns can be replicated on PMMA 0.7 µm thick with 20 µm spacings when the beam collimating angle is 2°.
Novel Routes to Bidentate Cyclopentadienyl−Alkoxide Complexes of Titanium:  Synthesis of (η<sup>5</sup>-σ-C<sub>5</sub>R<sup>1</sup><sub>4</sub>CHR<sup>2</sup>CH<sub>2</sub>CR<sup>3</sup>R<sup>4</sup>O)TiCl<sub>2</sub> (1999)

Reaction of C5R14(SiMe3)CHR2CH2CR3R4OR5 with titanium tetrachloride gives the bidentate η5-σ-cyclopentadienyl−alkoxide complexes of titanium (η5-σ-C5R14CHR2CH2CR3R4O)TiCl2 through elimination of chlorotrimethylsilane and RCl (R = SiMe3, CH2Ph, CMe3). A potentially tridentate system (R1, R2, R3 = H, R4 = −(CH2)2OMe) was synthesized in optically pure form and its structure determined by X-ray diffraction. The pendant ether oxygen does not coordinate to the metal, and hydride transfer reactions catalyzed by the complex gave racemic products. Efficient routes to tetramethylcyclopentadienyl-substituted ligands (R1 = Me) were developed on the basis of the addition of 2-butenylmagnesium bromide to γ-lactones to give the dienyl alcohols [C(CH3)CH(CH3)]2C(OH)CHR2(CH2)2OH, which could be functionalized on the primary alcohol before acid-catalyzed cyclization to afford the 3-alkoxypropyl-substituted tetramethylcyclopentadienes.
Use of antenna nulling with frequency-hopping against the follower jammer (1991)

Antenna nulling is an effective ECCM (electronic counter countermeasures) asset that can be put in use with other ECCM techniques to obtain additional processing gain. Two antenna nulling schemes that can be used with frequency hopping to reduce the follower jammer threat are described. One of the schemes is only effective with uncorrelated signals. The second scheme is designed for coping with correlated jamming. Both schemes capitalize on the arrival time differences of the desired signal and the interference to isolate the interference for cancellation. The fast converging sample matrix inversion algorithm is considered in both schemes for improved effectiveness. The performance of the antenna nulling schemes, described in terms of the array output-signal-to-interference and noise ratio (OSINR), is evaluated by computer simulation. The OSINR of the array at a single frequency in the hop-set is presented for a range of desired signal-to-noise and jammer-to-noise ratios. The processing gain offered by the antenna nulling system was found to increase with increasing desired signal-to-noise ratio.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Anemia, hypertension, and myocardial dysfunction in end-stage renal disease. (1997)

Cardiovascular disease remains the major cause of mortality in patients with end stage renal disease (ESRD). The pathophysiology of cardiac dysfunction in ESRD is complex and not fully understood. However, it appears that the two major determinants of left ventricular (LV) hypertrophy and dysfunction are anemia and hypertension, both of which are very common in ESRD patients. Early and aggressive correction of anemia and hypertension may have a significant impact on cardiac disease in ESRD patients. This article presents a discussion on the management of anemia and hypertension, and the current information available on the pathogenesis and management of LV dysfunction in ESRD.
A COMPARATIVE STUDY OF SUPPORTS FOR THE SYNTHESIS OF OLIGONUCLEOTIDES WITHOUT USING AMMONIA (1996)

Abstract A comparative study of the cleavage efficiency of succinyl, phthaloyl, oxalyl, 2-(2-nitrophenyl)ethyl, 9-fluorenylmethyl, and 2-nitrobenzyl supports in 0.5M DBU solutions is described. A decrease in cleavage efficiency is observed when small oligonucleotides containing thymidine are linked to the supports. In these conditions oxalyl supports gave the best yields followed by 2-(2-nitrophenyl)ethyl and 9-fluorenylmethyl supports.
New and traditional smokeless tobacco: Comparison of toxicant and carcinogen levels (2008)

Declining cigarette use and spreading bans on smoking in public places in the United States are encouraging the U.S. cigarette industry to turn to another tobacco category, smokeless tobacco products. Currently, a number of new brands are being test marketed, including Taboka, Marlboro Snus, Camel Snus, and Skoal Dry. We report here levels of tobacco-specific nitrosamines (TSNAs), alkaloids, anions, polycyclic aromatic hydrocarbons (PAH), and volatile aldehydes in these products, and compare them to the most popular traditional moist snuff brands. Total TSNAs averaged 1.97 microg/g dry weight tobacco in Taboka, Marlboro Snus, and Camel Snus, 4.54 microg/g tobacco in Skoal Dry, and 7.42 microg/g tobacco in traditional brands. The amounts of unprotonated nicotine averaged 0.961 mg/g tobacco in Taboka, Marlboro Snus, and Skoal Dry, 7.22 mg/g tobacco in Camel Snus, and 7.57 mg/g tobacco in traditional brands. Levels of minor tobacco alkaloids were relatively high in Taboka, Marlboro Snus, and Skoal Dry, as compared to other products analyzed here. Levels of nitrite and nitrate in new U.S. smokeless tobacco products and the Swedish snus General were lower than those in the other products. Remarkably high levels of chloride and some PAH were observed in the traditional moist snuff. Crotonaldehyde levels were about five times higher in Taboka and Marlboro Snus than in traditional products. The large variation in the levels of some toxicants and carcinogens analyzed here indicates that more effort is required from the U.S. tobacco industry to further reduce their amounts in new and traditional smokeless tobacco products.
Ability of potent vitamin D3 analogs to inhibit growth of prostate cancer cells in vivo. (2003)

The MTD of the analogs varied by 400-fold but each had similar efficacy suggesting that, when choosing a vitamin D analog for clinical study, overall efficacy without toxicity is more important than the total amount of the compound that can be administered. In summary, we have identified three vitamin D analogs that show marked potency in vivo to inhibit growth of human prostate cancer xenografts; each had no detectable toxicity. This study should help lay the foundation for clinical studies.
Pottery and Other Finds from the Anglo-Saxon Cemetery at Sandy, Bedfordshire (1970)

INTENSIVE museum research and examination of documentary records of the discovery in the 18th and 19th centuries of Anglo-Saxon urns and other finds at Sandy (Beds.) reveals a series of 5th- to early 6th-century cremation urns and other pottery from the site. These are published together for the first time and their significance is discussed. A metal find of importance, a silver bracelet, is given extended treatment.
Spectral Slicing X-Ray Telescope (1986)

Layered synthetic microstructure (LSM) x-ray optics may be used to couple a conventional glancing incidence x-ray mirror to a high sensitivity x-ray detector. The LSM mirror is a thin-film multilayer optic that effectively reflects only narrow spectral slices of the incident radiation by Bragg diffraction. By the use of figured LSM optics, it is possible to magnify the x-ray image produced by the primary mirrors so as to maintain their high inherent spatial resolution when used with currently available solid-state detectors. The results of theoretical design and analysis studies of several Spectral Slicing X-Ray Telescope (SSXRT) systems utilizing LSM mirrors figured as hyperboloids, spheres, ellip-soids, and constant optical path aspheric elements are presented. The rms spot size and point response function calculations are given for telescopes in which the LSM optics are designed to yield magnifications of 2 X, 6 X, and 8 X. The results of tilt and decentration studies are discussed. It has been demonstrated that the off-axis optical performance of the SSXRT is superior to that produced by the conventional glancing incidence primary mirror alone. The Stanford/Marshall Space Flight Center Rocket X-Ray Telescope, which will utilize normal incidence LSM optics to couple a Wolter-Schwarzschild primary mirror to high resolution detectors for solar x-ray/EUV studies, is briefly discussed.
Managing the cost, energy consumption, and carbon footprint of internet services (2010)

The large amount of energy consumed by Internet services represents significant and fast-growing financial and environmental costs. This paper introduces a general, optimization-based framework and several request distribution policies that enable multi-data-center services to manage their brown energy consumption and leverage green energy, while respecting their service-level agreements (SLAs) and minimizing energy cost. Our policies can be used to abide by caps on brown energy consumption that might arise from various scenarios such as government imposed Kyoto-style carbon limits. Extensive simulations and real experiments show that our policies allow a service to trade off consumption and cost. For example, using our policies, a service can reduce brown energy consumption by 24% for only a 10% increase in cost, while still abiding by SLAs.
Mutation in a short-chain collagen gene, CTRP5 , results in extracellular deposit formation in late-onset retinal degeneration: a genetic model for age-related macular degeneration (2003)

A primary feature of age-related macular degeneration (AMD) is the presence of extracellular deposits between the retinal pigment epithelium (RPE) and underlying Bruch's membrane, leading to RPE dysfunction, photoreceptor death and severe visual loss. AMD accounts for about 50% of blind registrations in Western countries and is a common, genetically complex disorder. Very little is known regarding its molecular basis. Late-onset retinal degeneration (L-ORD) is an autosomal dominant disorder with striking clinical and pathological similarity to AMD. Here we show that L-ORD is genetically heterogeneous and that a proposed founder mutation in the CTRP5 (C1QTNF5) gene, which encodes a novel short-chain collagen, changes a highly conserved serine to arginine (Ser163Arg) in 7/14 L-ORD families and 0/1000 control individuals. The mutation occurs in the gC1q domain of CTRP5 and results in abnormal high molecular weight aggregate formation which may alter its higher-order structure and interactions. These results indicate a novel disease mechanism involving abnormal adhesion between RPE and Bruch's membrane.
A CNN Accelerator on FPGA Using Depthwise Separable Convolution (2018)

Convolutional neural networks (CNNs) have been widely deployed in the fields of computer vision and pattern recognition because of their high accuracy. However, large convolution operations are computing intensive and often require a powerful computing platform such as a graphics processing unit. This makes it difficult to apply CNNs to portable devices. The state-of-the-art CNNs, such as MobileNetV2 and Xception, adopt depthwise separable convolution to replace the standard convolution for embedded platforms, which significantly reduces operations and parameters with only limited loss in accuracy. This highly structured model is very suitable for field-programmable gate array (FPGA) implementation. In this brief, a scalable high performance depthwise separable convolution optimized CNN accelerator is proposed. The accelerator can be fit into an FPGA of different sizes, provided the balancing between hardware resources and processing speed. As an example, MobileNetV2 is implemented on Arria 10 SoC FPGA, and the results show this accelerator can classify each picture from ImageNet in 3.75 ms, which is about 266.6 frames per second. The FPGA design achieves 20× speedup if compared to CPU.
Linear and Rectangular Trinuclear Phthalocyanines (2006)

Abstract Isomeric linear and rectangular trinuclear metal‐free andzinc(II) phthalocyanine complexes connected by common annulated benzene rings have been synthesized by the mixed cyclotetramerization of a 1,2,4,5‐tetracyanobenzene derivative and 4,5‐bis(2,6‐dimethylphenoxy)phthalonitrile. Their electronic‐absorption and fluorescence spectra have been studied in comparison with the corresponding mono‐ and dinuclear phthalocyanines. For the zinc complexes, the molecular orbitals and electronic spectra have been calculated semi‐empirically. The trinuclear phthalocyanines exhibit absorptions up to 940 nm with extinction coefficients up to about 700000 M –1 cm –1 , which shows the extension of the π‐electron system.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
PACT-a software package to manage projects and coordinate people (2002)

PACT is a software package that extends Microsoft Project by endowing it with extensive features needed to coordinate projects among distributed participants and manage their inter-dependencies. Significant features include: support for multiple users; comprehensive RDBMS to store project history and maintain strict access control; common visibility of the project network to all team members, no matter where they are on a network; direct involvement by participants in the coordination of the project; practical metrics to assess projects, at the planning phase itself, using the most recent project data; worklist queues to notify members of the project when changes occur; attachment of the results of tasks to the tasks themselves for others to instantly obtain all the technical information needed to perform subsequent tasks; paperless working is thus made possible.