gebhart/patrepeval huggingface dataset:
miR-125b inhibited epithelialal&ndash;mesenchymal transition of triple-negative breast cancer by targeting MAP2K7 (2016)

MicroRNAs (miRNAs) play important roles in diverse biological processes and are emerging as key regulators of tumorigenesis and tumor progression. Among the differentially expressed miRNAs in breast cancer, miR-125b was revealed to be deregulated and associated with poor prognosis and chemoresistance in triple-negative breast cancer (TNBC), but the mechanism is still unknown. In our study, we showed downregulated expression of miR-125b in TNBC tissues and decreased migration and invasion in miR-125b-expressing Hs578T cells. MAP2K7 was then detected to be a novel target of miR-125b, and downregulation of MAP2K7 by miR-125b was similar to transient knockdown of MAP2K7 which hindered epithelial-mesenchymal transition (EMT) of Hs578T cells. Upregulation of MAP2K7 in miR-125b-overexpressing Hs578T cells partly rescued the migration and invasion suppression of miR-125b. Furthermore, MAP2K7 was overexpressed in TNBC samples compared with normal tissues and negatively correlated with miR-125b expression. In light of these findings, miR-125b emerged as a tumor suppressor in TNBC by targeting MAP2K7 to inhibit EMT.
Antimicrobial Resistance in (2007)

Intubated patients often become colonized and subsequently infected by Pseudomonas aeruginosa. The pathogen is difficult to eradicate because it
<title>Disk layout of near-video-on-demand system</title> (1997)

This paper discusses a novel data placement scheme which optimizes the storage utilization of a NVOD system. The scheme is most distinctive in the following two aspects: (1) It considers the file blocks placement of programs featured different number NVOD channels. (2) The file blocks grouping scheme optimizes the storage utilization of a NVOD system.
Distributed aberrators for emulation of ultrasonic pulse distortion by abdominal wall (2002)

The characteristics of phantoms that mimic first- and second-order statistics of ultrasonic pulse distortion produced by the human abdominal wall are described. The phantoms consist of a fat-mimicking background in which aberrating spheres of different size are randomly distributed. The focus degradation produced by the phantoms resembles the degradation measured for abdominal wall specimens but is greater than that produced by specimens with similar aberration statistics. Compared to silicone rubber sheets that are often used as thin phase screens, these phantoms provide more realistic aberration for controlled studies of focusing through tissue.
Mixing Process of Binary Polymer Particles in Different Type of Mixers (2009)

The main objective of this paper is to investigate the mixing process of free flowing polymers binary mixtures at different densities and colors in two different mixers, namely the bubbling fluidized bed and V-mixer. The mixing of solids was studied by analyzing the variation of the proportions of the marked particles with time and position in the bed or in the mixer. The variation of mixture composition based on the samples was incorporated into Lacey mixing index which describes the degree of mixing of the particles at particular time. The performance and the mixing behavior in these two mixers were also presented. Results showed that gas velocity and bed depth were important parameters influencing solids mixing in a bubbling fluidized bed. While the rotation speeds and filled up levels were proved as important parameters in influencing the solids mixing in V-mixer. From the results, complete mixings were attained at a bed depth of 17 cm and gas velocity of 1.38Umf in the fluidized bed and 40 % filled up level and 40 rpm in the V-mixer. From the energy consumption point of view, it was found that the fluidized bed mixer offers the most efficient and economical process compared to V-mixer.
Manganese superoxide dismutase expression in endothelial progenitor cells accelerates wound healing in diabetic mice (2010)

Amputation as a result of impaired wound healing is a serious complication of diabetes. Inadequate angiogenesis contributes to poor wound healing in diabetic patients. Endothelial progenitor cells (EPCs) normally augment angiogenesis and wound repair but are functionally impaired in diabetics. Here we report that decreased expression of manganese superoxide dismutase (MnSOD) in EPCs contributes to impaired would healing in a mouse model of type 2 diabetes. A decreased frequency of circulating EPCs was detected in type 2 diabetic (db/db) mice, and when isolated, these cells exhibited decreased expression and activity of MnSOD. Wound healing and angiogenesis were markedly delayed in diabetic mice compared with normal controls. For cell therapy, topical transplantation of EPCs onto excisional wounds in diabetic mice demonstrated that diabetic EPCs were less effective than normal EPCs at accelerating wound closure. Transplantation of diabetic EPCs after MnSOD gene therapy restored their ability to mediate angiogenesis and wound repair. Conversely, siRNA-mediated knockdown of MnSOD in normal EPCs reduced their activity in diabetic wound healing assays. Increasing the number of transplanted diabetic EPCs also improved the rate of wound closure. Our findings demonstrate that cell therapy using diabetic EPCs after ex vivo MnSOD gene transfer accelerates their ability to heal wounds in a mouse model of type 2 diabetes.
Enamel remineralization by fluoride-releasing materials: proposal of a pH-cycling model (2010)

This study proposes a pH-cycling model for verifying the dose-response relationship in fluoride-releasing materials on remineralization in vitro. Sixty bovine enamel blocks were selected for the surface microhardness test (SMH1). Artificial caries lesions were induced and surface microhardness test (SMH2) was performed. Forty-eight specimens were prepared with Z 100, Fluroshield, Vitremer and Vitremer ¼ diluted - powder/liquid, and subjected to a pH-cycling model to promote remineralization. After pH-cycling, final surface microhardness (SMH3) was assessed to calculate percent recovery of surface microhardness (%SMHR). Fluoride present in enamel (μg F/mm3) and in the pH-cycling solutions (μg F) was measured. Cross-sectional microhardness was used to calculate mineral content (∆Z). There was no significant difference between Z 100 and control groups on analysis performed on - %SMHR, ∆Z, μg F and mg F/mm3 (p>0.05). Results showed a positive correlation between %SMHR and μg F/mm3 (r=0.9770; p=0.004), %SMHR and μg F (r=0.9939; p=0.0000001), ∆ and μg F/mm3 (r=0.9853; p=0.0002), ∆ and μg F (r=0.9975; p=0.0000001) and between μg F/mm3 and μg F (r=0.9819; p=0.001). The pH-cycling model proposed was able to verify in vitro dose-response relationship of fluoride-releasing materials on remineralization.
An experimental phylogeny to benchmark ancestral sequence reconstruction (2016)

Ancestral sequence reconstruction (ASR) is a still-burgeoning method that has revealed many key mechanisms of molecular evolution. One criticism of the approach is an inability to validate its algorithms within a biological context as opposed to a computer simulation. Here we build an experimental phylogeny using the gene of a single red fluorescent protein to address this criticism. The evolved phylogeny consists of 19 operational taxonomic units (leaves) and 17 ancestral bifurcations (nodes) that display a wide variety of fluorescent phenotypes. The 19 leaves then serve as 'modern' sequences that we subject to ASR analyses using various algorithms and to benchmark against the known ancestral genotypes and ancestral phenotypes. We confirm computer simulations that show all algorithms infer ancient sequences with high accuracy, yet we also reveal wide variation in the phenotypes encoded by incorrectly inferred sequences. Specifically, Bayesian methods incorporating rate variation significantly outperform the maximum parsimony criterion in phenotypic accuracy. Subsampling of extant sequences had minor effect on the inference of ancestral sequences.
Sn/Al 2 O 3 /C/CNT composite prepared by wet milling as anode material for lithium-ion cells (2017)

Sn/Al2O3/C/CNT (SAC/CNT) composite was synthesized by a simple wet milling route. The physico-chemical, structural and morphological properties of the material were studied. The electrochemical performance of the composite as an anode material in Li-ion cells was evaluated by Cyclic Voltammetry (CV), charge–discharge cycling and electrochemical impedance measurements. The SAC/CNT material delivered an initial specific capacity of 835 mAh g−1 with the coulombic efficiency of ∼77% along with good charge–discharge cycle performance retaining ∼88% of the initial capacity after 35 cycles. A comparison of the results with those for Sn/C (SC) and Sn/Al2O3/C (SAC) showed that the SAC/CNT composite exhibited better overall performance compared to the other two materials. The enhanced performance of SAC/CNT is attributed to the combined effect of the buffer action provided by Al2O3 accommodating volume changes of the electrode during cycling and the reduced charge transfer resistance of the electrode resulting from the inclusion of conductive CNTs.
Context-aware brain–computer interfaces: exploring the information space of user, technical system and environment (2011)

Brain-computer interface (BCI) systems are usually applied in highly controlled environments such as research laboratories or clinical setups. However, many BCI-based applications are implemented in more complex environments. For example, patients might want to use a BCI system at home, and users without disabilities could benefit from BCI systems in special working environments. In these contexts, it might be more difficult to reliably infer information about brain activity, because many intervening factors add up and disturb the BCI feature space. One solution for this problem would be adding context awareness to the system. We propose to augment the available information space with additional channels carrying information about the user state, the environment and the technical system. In particular, passive BCI systems seem to be capable of adding highly relevant context information-otherwise covert aspects of user state. In this paper, we present a theoretical framework based on general human-machine system research for adding context awareness to a BCI system. Building on that, we present results from a study on a passive BCI, which allows access to the covert aspect of user state related to the perceived loss of control. This study is a proof of concept and demonstrates that context awareness could beneficially be implemented in and combined with a BCI system or a general human-machine system. The EEG data from this experiment are available for public download at www.phypa.org.
Creep Behavior of Plasticized Polyvinyl Chloride Liquid Polymer Plasticizers (1950)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCreep Behavior of Plasticized Polyvinyl Chloride Liquid Polymer PlasticizersM. Daud Ali, Herman F. Mark, and Robert B. MesrobianCite this: Ind. Eng. Chem. 1950, 42, 3, 484–488Publication Date (Print):March 1, 1950Publication History Published online1 May 2002Published inissue 1 March 1950https://pubs.acs.org/doi/10.1021/ie50483a025https://doi.org/10.1021/ie50483a025research-articleACS PublicationsRequest reuse permissionsArticle Views54Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Stabilization of a DNA duplex under molecular crowding conditions of PEG (2004)

A living cell generally contains macromolecules occupying 20-40% of the total volume. To mimic the crowded cellular condition, we prepared solutions including poly(ethylene glycol) (PEG) as a cosolute and investigated the influence of the cosolute on the DNA duplex stability. In the presence of PEG 200 or PEG 8000, the Tm (melting temperature) of a self-complementary duplex of 5'-dATGCGCAT-3' decreased by 11.8 degrees C in the presence of 20 wt% PEG200 and by 1.5 degrees C in the presence of 20 wt% PEG 8000. The dln K(obs) vs. dln a(w) plots for PEG 200 and PEG 8000 were linear with a negative slope, suggesting the association of water molecules upon the duplex formation. Interestingly, when the NaCl concentration decreased from 1 M to 400 mM, the Tm increased in the presence of PEGs. Our results imply that the nucleic acid stabilities in a living cell may be different from those in in vitro conditions.
Two Spatially Distant Epitopes of Human Lactoferrin (1996)

Lactoferrin (LF) is an iron binding protein, which may represent a target for antineutrophil cytoplasmic antibodies (ANCA) in patients affected by rheumatoid arthritis, ulcerative colitis, and primary sclerosing cholangitis. Here we describe the production and characterization of two new monoclonal antibodies (MAbs) against human LF. These MAbs (AGM 10.14, an IgG1, and AGM 2.29, an IgG2b) recognize spatially distant epitopes of LF as assessed by cross-blocking experiments. We also demonstrated by indirect immunofluorescence that both MAbs react with ethanol-fixed neutrophil granulocytes showing a perinuclear staining pattern. AGM 2.29 and AGM 10.14 have been utilized as capture and labeled tracer antibody, respectively, in a double determinant immunoassay (DDIA) to measure soluble LF. The results obtained show that this DDIA allows us to quantify even low concentrations of LF, the maximal range of the assay sensitivity being between 12 and 780 ng/ml. Therefore, AGM 10.14 and AGM 2.29 may represent useful reagents for studying the role of autoantibodies to LF as well as for measuring soluble LF, which is a reliable secretory marker of neutrophil activation.
Standards for Hospice Care: Assumptions and Principles (1979)

Journal Article Standards for Hospice Care: Assumptions and Principles Get access Zelda Foster Zelda Foster About the Author Zelda Foster, MSW, is Assistant Director, University Hospital, New York University Medical Center, New York City. The author invites comments about the document presented here. Search for other works by this author on: Oxford Academic PubMed Google Scholar Health & Social Work, Volume 4, Issue 1, February 1979, Pages 117–128, https://doi.org/10.1093/hsw/4.1.117 Published: 01 February 1979
Eighth International Congress of Pesticide Chemistry : options 2000 : proceedings of a conference (1995)

World Food Security up to 2010 and the Global Pesticide Situation Searching for Clues to Mechanism and New Directions in Synthesis Through SAR and Modeling 3-Aryl-4-halo-5-substituted Pyrazoles: A New Class of Highly Active Preemergent and Postemergent Herbicides Chloronicotinyl Insecticides: Development of Imidacloprid The Synthesis of Fungicidal *b-Methoxyacrylates Dispersions and Dispersible Systems Packaging and Application Technology Controlled Release Systems: Prospects for the Future Biopesticide Formulations and Their Applications Movement of Pesticides to Non-Target Areas Fate of Pesticides in Subsurface Soils and Groundwater Fate of Herbicides and Organochlorine Insecticides in Lake Waters Origin and Fate of Pesticides in Air The Evolution of a Multiresidue Pesticide Method Isomer- and Enantioselective Residue Analysis of Chlorinated Pesticides Using Chiral High Resolution Gas Chromatography and Various Mass Spectrometric Detection Techniques Opportunities for Pesticide Residue Analytical Method Development: The Potential for Aqueous Extractions of Pesticide Residues from Fruits and Vegetables Residues: Biotechnology-Based Methods Biotechnology in the Production of Disease and Pest Control Agents Approaches to Identify Genes for Disease Resistance in Plants Regulatory Aspects in the European Union of Foods Derived from Modern Biotechnology Metabolism and Transport Related Mechanisms in Organ-Directed Toxicity Plant Metabolism and the Design of New Selective Herbicides Advances in Metabolite Identification Biotransformation in Aquatic Animals: Pesticides Revisited The Influences of Molecular Mechanisms of Action on Herbicide Design Influence of Molecular Mechanism of Action on Herbicide Use Rate Molecular Neurobiology and Insecticide Discovery Influences of Molecular Mechanisms of Action on Fungicide Design Catch 22: Mutually Exclusive Strategies for Delaying/Preventing Polygenically vs. Monogenically Inherited Resistances Managing Resistance to Sterol Demethylation Inhibitors Status and Future of Synergists in Resistance Management Conversion of Hazard to Risk: A High-Cost Mistake New Directions in Pesticide Risk Reduction: Report from North America New Directions: Report from Europe Pesticide Registration and Establishment of Maximum Residue Limits in Latin America Health Risk Assessment: Challenges and Opportunities Health Risk Assessment: Critical Issues for Improved Decision Making Ecotoxicological Risk Assessment of Pesticides in Soil Ecological Risk Assessment of Pesticides: The Role of Field Data
An Approach to the Initial Care of Patients with Chest Pain An Approach to the Initial Care of Patients with Chest Pain in an Emergency Department Located in a Non-Cardiac Center (2009)

Emergency department management of chest pain is a common, with potentially serious problem. With multiple risk factors, target groups, and care pathways, the myriad etiologies of chest pain can be perplexing. This article describes some of the diagnostic and risk stratification scenarios currently used in departments which do not have percutaneous cardiac intervention capabilities.
Fundamental study on recovery uranium oxide from HEPA filters (1993)

Large numbers of spent HEPA filters are produced at uranium fuel fabrication facilities. Uranium oxide particles have been collected on these filters. Then, a spent HEPA filter treatment system was developed from the viewpoint of recovering the UO{sub 2} and minimizing the volume. The system consists of a mechanical separation process and a chemical dissolution process. This paper describes the results of fundamental experiments on recovering UO{sub 2} from HEPA filters.
Total synthesis of a novel antiulcer agent via a modification of the intramolecular Wadsworth-Emmons-Wittig reaction (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal synthesis of a novel antiulcer agent via a modification of the intramolecular Wadsworth-Emmons-Wittig reactionPaul A. Aristoff, Paul D. Johnson, and Allen W. HarrisonCite this: J. Am. Chem. Soc. 1985, 107, 26, 7967–7974Publication Date (Print):December 1, 1985Publication History Published online1 May 2002Published inissue 1 December 1985https://pubs.acs.org/doi/10.1021/ja00312a028https://doi.org/10.1021/ja00312a028research-articleACS PublicationsRequest reuse permissionsArticle Views1759Altmetric-Citations66LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Antioxidant Activity and Emulsion-Stabilizing Effect of Pectic Enzyme Treated Pectin in Soy Protein Isolate-Stabilized Oil/Water Emulsion (2011)

The antioxidant activity of pectic enzyme treated pectin (PET-pectin) prepared from citrus pectin by enzymatic hydrolysis and its potential use as a stabilizer and an antioxidant for soy protein isolate (SPI)-stabilized oil in water (O/W) emulsion were investigated. Trolox equivalent antioxidant capacity (TEAC) was found to be positively associated with molecular weight (M(w)) of PET-pectin and negatively associated with degree of esterification (DE) of PET-pectin. PET-pectin (1 kDa and 11.6% DE) prepared from citrus pectin after 24 h of hydrolysis by commercial pectic enzyme produced by Aspergillus niger expressed higher α,α-diphenyl-β-picrylhydrazyl (DPPH) radical scavenging activity, TEAC, and reducing power than untreated citrus pectin (353 kDa and 60% DE). The addition of PET-pectin could increase both emulsifying activity (EA) and emulsion stability (ES) of SPI-stabilized O/W emulsion. When the SPI-stabilized lipid droplet was coated with the mixture of PET-pectin and pectin, the EA and ES of the emulsion were improved more than they were when the lipid droplet was coated with either pectin or PET-pectin alone. The amount of secondary oxidation products (thiobarbituric acid reactive substances) produced in the emulsion prepared with the mixture of SPI and PET-pectin was less than the amount produced in the emulsion prepared with either SPI or SPI/pectin. These results suggest that PET-pectin has an emulsion-stabilizing effect and lipid oxidation inhibition ability on SPI-stabilized emulsion. Therefore, PET-pectin can be used as a stabilizer as well as an antioxidant in plant origin in SPI-stabilized O/W emulsion and thus prolong the shelf life of food emulsion.
Rule Inducted Models for Classifying Water Quality Using Diatoms as Bio-indicators (2009)

In this paper we use the property of diatoms as bioindicators, to indentify which WQC is the taken sample using machine learning classifying algorithm - CN2. Important physical-chemical parameters such as conductivity, saturated oxygen and mostly used pH have defined range in which water class they belong. These physical-chemical parameters have influence on the entire lake web food chain, thus disturbing the organism's patterns and interactions between them, such as diatoms community. These communities have where high coefficient of indication on certain process such as eutrophication, which means that they can be used as bio-indicators of water quality. The CN2 algorithm can produce rules in a form IF-THEN which is suitable for organizing knowledge from diatoms abundance data. In literature the diatoms have ecological preference organized in the same manner. The experimental setup is build to satisfy not only the algorithm properties, but also the ecological knowledge of the diatoms community. We used several modifications of the algorithm, from which we compare the classification accuracy or rule quality to point which experiment proved to be most accuracy and more general. Several of the rules are presented in this paper together with the evaluation performance. Based on modifications of the CN2 algorithm parameters, we were able to extract certain knowledge form the data, which later have proved to be valid, or in some cases is novel for many newly discovered diatoms. In future we plan to investigate more modifications of the CN2 algorithm, also to implement multi-classification rule induction and compare these results to the single target.