gebhart/patrepeval huggingface dataset:
Evidence that latent collagenases are enzyme-inhibitor complexes (1977)

Specific collagenase from the culture media of various rabbit tissues and cells exists in active and latent forms. Latent collagenase is most effectively activated with 4-aminophenylmercuric acetate, a thiol-blocking reagent, strongly suggesting that latent forms are enzyme-inhibitor complexes. A collagenase inhibitor from bone cultures, which may be closely related to the inhibitor of such latent enzyme complexes, was partially characterized.
Analysis of the charge distribution in the C‐terminal region of histone H1 as related to its interaction with DNA (1990)

We have studied the net positive charge distribution in the C-terminal region of histone H1. We find that it is not random, but rather uniform. In most histone H1 sequences, 4 +/- 1 positive charges are found in this region of the molecule in over 95% of all possible segments that are 10 amino acids long. Neither alternating sequences (basic-nonbasic) nor more complex repeating sequences are ever found. Clusters of three or more basic amino acids are seldom observed in somatic H1s, yet their presence increases in sperm histones and even more so in protamines. It is concluded that the C-terminal region of histone H1 has a remarkably uniform distribution of charge, in spite of its apparent variations in sequence in different proteins and within individual molecules. The functional significance of these findings is discussed, suggesting a purely electrostatic role for the C-terminal region of histone H1, which may be evenly wrapped around individual segments of DNA molecules, thus decreasing its net charge. A likely candidate for a long alpha-helical region in the C-terminal region of histone H1 from sea urchin spermatozoa also has been located. This region may contribute to the aggregating properties of this histone in sperm chromatin.
New Silicon Architectures by Gold-Assisted Chemical Etching (2011)

Silicon nanowires (SiNWs) were produced by nanosphere lithography and metal assisted chemical etching. The combination of these methods allows the morphology and organization control of Si NWs on a large area. From the investigation of major parameters affecting the etching such as doping type, doping concentration of the substrate, we demonstrate the formation of new Si architectures consisting of organized Si NW arrays formed on a micro/mesoporous silicon layer with different thickness. These investigations will allow us to better understand the mechanism of Si etching to enable a wide range of applications such as molecular sensing, and for thermoelectric and photovoltaic devices.
Effects of surface-modified silica nanoparticles attached graphene oxide using isocyanate-terminated flexible polymer chains on the mechanical properties of epoxy composites (2014)

Surface modified silica nanoparticles attached to graphene oxide using isocyanate terminated flexible chains were used for toughening epoxy.
Joint resource allocation and base-station assignment for the downlink in CDMA networks (2006)

In this paper, we jointly consider the resource allocation and base-station assignment problems for the downlink in CDMA networks that could carry heterogeneous data services. We first study a joint power and rate allocation problem that attempts to maximize the expected throughput of the system. This problem is inherently difficult because it is in fact a nonconvex optimization problem. To solve this problem, we develop a distributed algorithm based on dynamic pricing. This algorithm provides a power and rate allocation that is asymptotically optimal in the number of mobiles. We also study the effect of various factors on the development of efficient resource allocation strategies. Finally, using the outcome of the power and rate allocation algorithm, we develop a pricing-based base-station assignment algorithm that results in an overall joint resource allocation and base-station assignment. In this algorithm, a base-station is assigned to each mobile taking into account the congestion level of the base-station as well as the transmission environment of the mobile.
HMC-1 Mast Cells Activate Human Orbital Fibroblasts in Coculture: Evidence for Up-Regulation of Prostaglandin E2 and Hyaluronan Synthesis* (1999)

The purpose of this study was to determine the effects of mast cell coculture on human orbital fibroblasts. Thyroid-associated ophthalmopathy is characterized by infiltration of lymphocytes and mast cells and connective tissue activation in the orbit, leading to a disordered accumulation of hyaluronan and intense inflammation. Here, we report that HMC-1, an established human mast cell line, can activate human orbital fibroblasts to produce increased levels of prostaglandin E2 (PGE2) and hyaluronan when cocultured. HMC-1 cells up-regulate, in these fibroblasts, the expression of PG endoperoxide H synthase-2 (EC 1.14.99.1, PGHS-2), the inflammatory cyclooxygenase. This induction, at a pretranslational level, underlies the increase in PGE2 synthesis. The up-regulation can be attenuated with dexamethasone (10 nM), and the increase in PGE2 production can be inhibited by SC 58125, a specific PGHS-2 inhibitor. Moreover, anti-interleukin-4 receptor antibodies can block prostanoid production in the fibroblasts elicited by HMC-1 cells, suggesting that this cytokine might represent a molecular conduit for mast cell/fibroblast cross-talk. HMC-1 cells also increased hyaluronan synthesis, as was evidenced by a 2-fold increase in [3H]glucosamine incorporation into the macromolecule. To our knowledge, these findings are the first demonstrating the ability of mast cells to activate orbital fibroblasts, and the findings suggest a potential role for these cell-cell interactions in the pathogenesis of thyroid-associated ophthalmopathy.
Fuzzy sets- based voltage control strategy for radial distribution systems (2008)

In this paper, Fuzzy-based voltage control in a realistic distribution system that is a part of the North Delta Electricity Distribution Company network in Egypt is concerned. This system includes tap-changed main transformer, synchronous condenser and feeders switched capacitors whose operation is to be coordinated. The imprecise linguistic expressions associated to practical operation are treated via fuzzy sets. First, the objective function and constraints are formulated in terms of fuzzy sets. Then, a direct search optimization technique is adopted to solve the problem to determine the optimal dispatching schedule of the main transformer tap position, feeders capacitors on/off status and synchronous condenser reactive power on hour-by-hour basis throughout the day. Extensive results are discussed while comparing the proposed voltage control strategy versus two others.
Consistency of models (1980)

article Free Access Share on Consistency of modelsACM SIGMOD RecordVolume 11Issue 2Feb 1981 pp 72–76https://doi.org/10.1145/960126.806879Online:23 June 1980Publication History 1citation123DownloadsMetricsTotal Citations1Total Downloads123Last 12 Months5Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
A rapid QAR data acquisition and visualization system for aircraft engine maintenances (2009)

We developed an aircraft engine maintenance support system that can be used for quick delivery of aircraft QAR data and can support engineers to analyze QAR data to check engine health. Instead of physical logistic, QAR upload subsystem can transfer QAR data electronically from shipside to the remote server via networks. Then, engine-related parameters are extracted from transferred QAR data and stored into the maintenance database. The engine-related parameters in the maintenance database can be shared among several engineers for engine health monitoring at different places and the analysis results will be also used for collaborative analysis.
A Study on Extraction Silver by reducing Siver-manganese Ore with FeSO_4 (2006)

SilverManganese ore is an important mineral.It is significant to recover valuable metals from the mineral.The process using FeSO_4 and NaCN to leach Mn and Ag respectively from silvermanganese ore is investigated.The effects of major process parameters are studied.Under the optimum technological conditions,the leaching efficiencies of Mn and Ag are 98% and 91% respectively.
Magnetoplasma Surface Waves in Metals (1972)

The effect of a dc magnetic field of arbitrary magnitude and orienation on surface plasmons in a metal or degenerate semiconductor is studied in the "nonretarded" limit.Received 3 January 1972DOI:https://doi.org/10.1103/PhysRevB.5.4707©1972 American Physical Society
Derivatives of Morphine. IV.<sup>1</sup> 14-Hydroxymorphine and 14-Hydroxydihydromorphine (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDerivatives of Morphine. IV.1 14-Hydroxymorphine and 14-HydroxydihydromorphineUlrich Weiss and Sol J. DaumCite this: J. Med. Chem. 1965, 8, 1, 123–125Publication Date (Print):January 1, 1965Publication History Published online1 May 2002Published inissue 1 January 1965https://pubs.acs.org/doi/10.1021/jm00325a028https://doi.org/10.1021/jm00325a028research-articleACS PublicationsRequest reuse permissionsArticle Views188Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
C3 convertase of the human alternative pathway of complement: modulation of enzyme activity and stability by mouse monoclonal antibodies to Bb (1987)

To further characterize functional sites on C3b,Bb, and C3 convertase of the alternative pathway of complement, we examined the effect of four monoclonal antibodies on its activity and stability. These antibodies recognized antigenic epitopes on human Bb which were not fully exposed in intact factor B. Three of the monoclonal antibodies inhibited lysis of rabbit erythrocytes by normal human serum in the presence of Mg2+ and EGTA. Two of these antibodies markedly inhibited the activity of purified C3b,Bb deposited on rabbit erythrocytes. However, all four monoclonal antibodies increased the half-life of the C3 convertase. Thus, these results demonstrate that binding of antibodies to Bb may concomitantly stabilize C3b,Bb and abate its activity. It is likely that such antibodies induce in Bb conformational changes which increase the C3b,Bb complex stability but may also hinder its catalytic site.
Enteric Coccidiosis among Patients with the Acquired Immunodeficiency Syndrome (1984)

Ten patients were identified at Jackson Memorial hospital/University of Miami Hospitals and Clinics with enteric coccidial infection due to Cryptosporidium spp. or Isospora belli. All had the acquired immunodeficiency syndrome as manifested by Kaposi's sarcoma or multiple opportunistic infections, or both. They presented with profuse diarrhea associated with weakness, anorexia, and weight loss. Routine examinations of stools for eggs and parasites as performed by the hospital laboratory were negative in all patients. Sugar flotation and modified acid fast techniques were used in the Tropical Disease Laboratory to identify oocysts of Cryptosporidium spp. in stools of seven patients. Malabsorption, characterized by a low 5-hour D-xylose and positive fecal fat, was observed in 6/6 of these patients. In three other patients Isospora belli oocysts were identified in stool specimens or via a duodenal string test. Spiramycin was the only drug found to be effective in treating patients with cryptosporidiosis. Patients with Isospora belli responded to a prolonged course of trimethoprim-sulfamethoxazole.
P38 MAP Kinase Signaling Is Required for the Conversion of CD4+CD25− T Cells into iTreg (2008)

CD4+CD25+ regulatory T cells (Treg) are important mediators of immune tolerance. A subset of Treg can be generated in the periphery by TGF-beta dependent conversion of conventional CD4+CD25- T cells into induced Treg (iTreg). In chronic viral infection or malignancy, such induced iTreg, which limit the depletion of aberrant or infected cells, may be of pathogenic relevance. To identify potential targets for therapeutic intervention, we investigated the TGF-beta signaling in Treg. In contrast to conventional CD4+ T cells, Treg exhibited marked activation of the p38 MAP kinase pathway. Inhibition of p38 MAP kinase activity prevented the TGF-beta-dependent conversion of CD4+CD25- T cells into Foxp3+ iTreg in vitro. Of note, the suppressive capacity of nTreg was not affected by inhibiting p38 MAP kinase. Our findings indicate that signaling via p38 MAP kinase seems to be important for the peripheral generation of iTreg; p38 MAP kinase could thus be a therapeutic target to enhance immunity to chronic viral infection or cancer.
Myocardial T1 mapping: where are we now and where are we going? (2014)

Abstract: Cardiovascular magnetic resonance offers noninvasive myocardial tissue characterization as a key unique strength over other imaging techniques. In particular T1, a tissue property that alters with disease, has gained prominence as a diagnostic tool. Prior to the administration of contrast, the native T1 changes with a number of processes such as fibrosis, edema, and infiltration. If a post-contrast scan is also acquired, the post-contrast T1 and extracellular volume fraction can be measured. Detecting and quantifying early and established myocardial pathological processes permits better diagnosis, prognostication, and tracking of therapy. Keywords: extracellular volume fraction, diffuse fibrosis, interstitium, cardiac remodeling, myocardial intracellular volume
<i>N</i>-Ethyl-<i>N</i>-phenyl-<i>N</i>′-tosylformamidine (2009)

The title compound, C(16)H(18)N(2)O(2)S, was obtained as an unexpected product while attempting to form carbon-nitro-gen bonds by catalytic amidation. The mol-ecule displays an E conformation about the C=N double bond. The planes of the two aromatic rings in the mol-ecule form a dihedral angle of 47.06 (9)°.
Carcinogenic activity of some heterocyclic analogs of p-dimethylaminoazobenzene. II. Effects of methyl groups in the pyridine ring. (1954)

Summary 1.A new series of compounds in which the pyridine and pyridine-1-oxide rings were substituted for a benzene ring of p -dimethylaminoazobenzene (DAB) were prepared and tested for ability to induce rat tumors. 2.The compounds tested were 4-methylpyridine-2-azo- p -dimethylaniline (4-Me-P2), 6-methylpyridine-2-azo- p -dimethylaniline (6-Me-P2), 4-methylpyridine-1-oxide-2-azo- p -dimethylaniline (4-Me-PO2), 6-methylpyridine-1-oxide-2-azo- p -dimethylaniline (6-Me-PO2), 2-methylpyridine-4-azo- p -dimethylaniline (2-Me-P4), pyridine-1-oxide-3-azo- p -dimethylaniline (PO3), 2-methylpyridine-1-oxide-4-azo- p -dimethylaniline (2-Me-PO4), 3-methylpyridine-1-oxide-4-azo- p -dimethylaniline (3-Me-PO4), and 2,6-dimethylpyridine-1-oxide-4-azo- p -dimethylaniline (2,6-diMe-PO4). 3.Over a period of 10 months9 administration of the test compounds, 4-Me-P2, 6-Me-P2, 4-Me-PO2, and 6-Me-PO2 were ineffective in tumor production. 2-Me-P4 was observed to be more effective than P4 and about equivalent to DAB. PO3 was observed to be less active than PO4 and about as active as DAB. 3-Me-PO4 seemed to be more active than DAB and about equal to m ′-Me-DAB. 2-Me-PO4 and 2,6-diMe-PO4 both appeared far more active than m ′-Me-DAB and both are more active than PO4, which was the most potent of the compounds previously tested.
Scoresheet-based event relevance determination for energy efficiency in wireless sensor networks (2011)

As wireless sensor nodes are mostly battery- powered, energy-efficient operation is a necessity to use their confined energy budget optimally. This is especially true in the logistics domain, where timely and accurate monitoring of containers is required, while the cost pressure is high. Thus, besides the need for energy efficiency, wireless sensor network deployments in logistics require cost efficiency as well. As data transmission represents the most expensive operation in terms of energy consumption and monetary costs, we present a concept for the local determination of transmission relevance in this paper. By omitting irrelevant events from transmission, the amount of data to transmit is effectively reduced. Our approach employs concepts from the business economics sector and is based on the use of scoresheets, which evaluate information on a wireless sensor node to decide whether they are "worth" transmitting or not. Thus, a scoresheet-based approach provides a viable solution for local filtering to realize energy-and cost-efficient operation of a wireless sensor network while maintaining the benefits of data fidelity and real-time event notifications.
A mathematical analysis of flexural vibrations of piezoelectric beams with applications to angular rate sensors (1990)

A mathematical analysis of flexural vibrations of piezoelectric beams with applications to angular rate sensors
Familles et École : une relation à dépassionner (2009)

Les relations des familles avec l’École sont devenues si complexes qu’elles engendrent incompréhensions et déceptions des deux côtés de la barrière. Pourtant, des associations de parents d’élèves mais aussi des associations complémentaires de l’enseignement public, ont su mettre en valeur l’idée de co-éducation . Que faut-il entendre par ce terme ?
HS-RAID<sup>2</sup>: Optimizing Small Write Performance in HS-RAID (2016)

HS-RAID (Hybrid Semi-RAID), a power-aware RAID, saves energy by grouping disks in the array. All of the write operations in HS-RAID are small write which degrade the storage system’s performance severely. In this paper, we propose a redundancy algorithm, data incremental parity algorithm (DIP), which employs HS-RAID to minimize the write penalty and improves the performance and reliability of the storage systems. The experimental results show that HS-RAID 2 (HS-RAID with DIP) is faster and has higher reliability than HS-RAID remarkably.
Distribution of di(2-ethylhexyl) phthalate and products in blood and blood components. (1986)

In order to impart flexibility, plastic medical devices incorporate liquid plasticizers into their structure. Data from several laboratories, including ours, have shown that these compounds leach from blood bags and tubing during collection of blood, storage of various blood components and during kidney dialysis and cell and plasma apheresis procedures. After the plasticizer di(2-ethylhexyl) phthalate leaches from poly(vinyl chloride) blood packs, it is converted by a plasma enzyme to a more toxic metabolite, mono(2-ethylhexyl) phthalate. Blood fractionation products from outdated plasma contain mono(2-ethylhexyl) phthalate, the highest level being found in normal serum albumin. Recently, we have reported that di(2-ethylhexyl) phthalate actually binds to the red blood cell membrane and reduces its osmotic fragility. Current methods of red cells storage, which permit utilization up to 35 days after collection, are not possible without this membrane stabilization. Platelets are now stored for 5 days in the Fenwal PL 732 polyolefin bag. Although stated to be essentially free of liquid plasticizers, a significant level of leaching from this bag into the extracts of stored platelet concentrates was observed.
Enhancement‐mode AlGaN/GaN HEMT and MIS‐HEMT technology (2010)

Abstract AlGaN/GaN heterostructure devices are capable of delivering high‐frequency power amplifiers and power switches with performances far superior than those offered by the mainstream silicon technology and other advanced semiconductor technologies. Primarily driven by applications' need, the last few years have witnessed major effort in the development of AlGaN/GaN enhancement‐mode (E‐mode) HEMTs and MIS‐HEMT. This paper attempts to review the latest progresses in this technology, including alternative approaches and device characteristics. Application examples of the E‐mode HEMT technology are also discussed.
D-Lactate altered mitochondrial energy production in rat brain and heart but not liver (2012)

DLA was a poor respiratory substrate in brain and heart mitochondria and inhibited LLA and pyruvate usage in these tissues. Further studies are warranted to evaluate whether these findings support, in part, the possible neurological and cardiac toxicity caused by high DLA levels.
Mechanisms of resistance to 6-aminonicotinamide. (1996)

Several cell lines resistant to 6-aminonicotinamide (6-AN) have been isolated, some selected with 6-AN and others with tiazofurin. These cell lines have been characterized with respect to several parameters including cross-resistance to tiazofurin, ability to metabolize 6-AN or tiazofurin to the respective analog metabolites of NAD, accumulation of 6-phosphogluconate in the presence of drug, and levels of NAD pyrophosphorylase (EC 2.7.7.1). Cell lines selected with 6-AN (ANR) are not cross-resistant to tiazofurin and have retained the ability to synthesize the NAD analogs, 6-aminonicotinamide adenine dinucleotide (6-ANAD), the phosphorylated derivative (6-ANADP) and thiazole-4-carboxamide adenine dinucleotide (TAD) when treated with 6-AN or tiazofurin respectively. The cell lines selected with tiazofurin are all cross-resistant to 6-AN; the most resistant of the lines are unable to form the NAD analog metabolites in detectable amounts and appear deficient in NAD pyrophosphorylase (EC 2.7.7.1) activity, the enzyme that is presumably responsible for their formation. The parent CHO line accumulates 6-phosphogluconate in the presence of 6-AN indicating inhibition of 6-phosphogluconate dehydrogenase. Of the resistant cell lines only two of them accumulate this intermediate.
A dynamic and distributed domain-based mobility management method for mobile IPv6 (2003)

We address mobility management for the internet protocol version 6 in mobile networks, namely mobile IPv6 (MIPv6). To correctly transfer IPv6 packets to a mobile node (MN), the MN has to update its binding to the home network while roaming away from its home network. Mobile IP networks suffer high binding update traffic from high rates of handoffs and long packet delivery delay from the large distance to the home network. In this paper, we introduce a dynamic and distributed domain-based mobility management protocol for MIPv6 to reduce the binding update and packet delivery delay and traffic. We describe the basic protocol operations and examine the performance improvement of our mobility management over the previous mobile IP mobility management method by using simulations. We show that the dynamic approach provides the optimal mobility solution for MIPv6 and the distributed approach can decentralize the network load.