gebhart/patrepeval huggingface dataset:
Practical applications of TCM (2002)

The first VLSI implementation of a decoder for multiple-signal (pragmatic) trellis-coded modulation (TCM) is described. Integrated on the same device is an encoder and a decoder for a variable rate binary code. The IC discussed is a 64-state rate 2/3 or 3/4 (used in conjunction with 8 and 16 PSK modulation) TCM decoder. The decoder is also accompanied by a K=7 trellis encoder. Integrated on the TCM decoder is a variable-rate Viterbi decoder (rates 1/2, 3/4, 7/8, 1/3). The chip has been manufactured and tested. The performance in rate 2/3 8 PSK and rate 3/4 16 PSK is shown graphically. Included in each figure is the uncoded performance in addition to the simulated and measured data of the chip. The performance of the chip in the rest of the models is shown. The die size is 320 mils on a side. The device contains 17800 transistors and was fabricated in a state-of-the art 1.0 mu m process. The device has attained clock speeds above 30 MHz under nominal conditions. The power consumption at 10 Mbit/s is less than 0.75 W.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Functional protein microarray as molecular decathlete: A versatile player in clinical proteomics (2012)

Functional protein microarrays were developed as a high-throughput tool to overcome the limitations of DNA microarrays and to provide a versatile platform for protein functional analyses. Recent years have witnessed tremendous growth in the use of protein microarrays, particularly functional protein microarrays, to address important questions in the field of clinical proteomics. In this review, we will summarize some of the most innovative and exciting recent applications of protein microarrays in clinical proteomics, including biomarker identification, pathogen-host interactions, and cancer biology.
Safe Client/Server Web Development with Haskell (2016)

We demonstrate how two Haskell libraries - Reflex-Dom and Servant - provide a powerful and complete web development framework which uses typechecking to guarantee many security and correctness properties on both the client and the server. With types as our guide, we can ensure that the data passed to our API is of the right shape, that we are forced to sanitize user input (eliminating most of the possibilities for SQL injection or XSS attacks), and that user input errors are guaranteed to be handled. We use Reflex, a Functional Reactive Programming engine, compiled with GHCJS (the Haskell-to-JavaScript transpiler) to lift user input into a safe representation. Types are used to enforce that all required data is requested from a user before the user can proceed to the next action in a workflow. Malformed user input is also cleanly separated at the type level for automatic reporting and recovery. Tutorial exercises will highlight Servant's guarantees that a REST API is fully specified for all possible user inputs and return conditions. Tutorial attendees will gain an appreciation of how much work this up-front specification can save in development time. For example, Servant knows what all of your endpoints are, and serves error pages for everything else. Servant can also safely handle data conversions from the world of untyped Strings into the typesafe world of your API.
Comparison of once‐daily nifedipine controlled‐release with twice‐daily nifedipine retard in the treatment of essential hypertension (2004)

These results demonstrate that both nifedipine CR and nifedipine retard are effective as antihypertensive agents, but nifedipine CR has less influence on the autonomic nervous system and heart rate than nifedipine retard.
Evolution of Carbon Microstructures during the Pyrolysis of Turkish Elbistan Lignite in the Temperature Range 700−1000 °C (2004)

Chars and activated carbons were produced from raw, HCl-washed, and HCl/HF-washed Elbistan lignites at 700 °C, 800 °C, 900 °C, and 1000 °C. The pyrolysis and activation reactions increased the BET areas (m2/g carbon) of the acid-washed samples almost 10-fold. The increase of the BET areas (m2/g carbon) by increasing the temperature of pyrolysis or activation from 700 °C to 1000 °C was explained with the burn-out of carbon which led to the development of porosity. The values of the stacking heights, Lc of HCl/HF-washed samples seemed to increase from 1.0 nm to 1.5 nm, the average number of graphene sheets increased from 2.8 to 4.4, and the lateral size of the crystallites, La, increased very faintly from 5.0 nm to 5.5 nm when the pyrolysis temperature was increased from 700 °C to 1000 °C. Activation reactions performed at the same temperature range did not change the stacking heights. The values of Lc for activated HCl/HF-washed samples stayed almost constant in the same range as for the carbonized samples within 1.0−1.5 nm. This indicated that oxidative reactions during activation did not alter the stacking heights of the crystallites significantly in the temperature range of 700−1000 °C. The results presented in the present work can be considered as indications for the development of turbostratic (fully disordered) structures in the temperature range of 700−1000 °C.
Trajectory recovery and 3D mapping from rotation-compensated imagery for an airship (2007)

On this paper, inertial orientation measurements are exploited to compensate the rotational degrees of freedom for an aerial vehicle carrying a perspective camera, taking a sequence of images of the ground plane. It is known that, on the pure translation case, full homographies are reduced to planar homologies, and the relative scene depth of two points equals the reciprocal ratio of their image distances to the the FOE. The first part of this paper covers trajectory recovery for an airship carrying a perspective camera taking a sequence of images of the ground plane, as a series of relative poses between successive camera poses. This is commonly named “Visual Odometry“. Previous results showed that the ratio of heights over the ground plane on two views can be calculated more accurately, and thus the altitude component of the trajectory, and here these results are extended by recovering the full 3D camera trajectory. In the second part, the same rotation-compensated imagery is exploited on the mapping domain: from pixel correspondences between successive images the height of points over the ground plane can be recovered, and placed on a DEM grid, performing 3D mapping from monocular aerial images. These results may be useful on the SLAM context.
Quantitative Analyses of Circadian Gene Expression in Mammalian Cell Cultures (2006)

The central circadian pacemaker is located in the hypothalamus of mammals, but essentially the same oscillating system operates in peripheral tissues and even in immortalized cell lines. Using luciferase reporters that allow automated monitoring of circadian gene expression in mammalian fibroblasts, we report the collection and analysis of precise rhythmic data from these cells. We use these methods to analyze signaling pathways of peripheral tissues by studying the responses of Rat-1 fibroblasts to ten different compounds. To quantify these rhythms, which show significant variation and large non-stationarities (damping and baseline drifting), we developed a new fast Fourier transform-nonlinear least squares analysis procedure that specifically optimizes the quantification of amplitude for circadian rhythm data. This enhanced analysis method successfully distinguishes among the ten signaling compounds for their rhythm-inducing properties. We pursued detailed analyses of the responses to two of these compounds that induced the highest amplitude rhythms in fibroblasts, forskolin (an activator of adenylyl cyclase), and dexamethasone (an agonist of glucocorticoid receptors). Our quantitative analyses clearly indicate that the synchronization mechanisms by the cAMP and glucocorticoid pathways are different, implying that actions of different genes stimulated by these pathways lead to distinctive programs of circadian synchronization.
Fluorinated Paraffins (1959)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFluorinated ParaffinsR. H. GROTHCite this: J. Org. Chem. 1959, 24, 11, 1709–1715Publication Date (Print):November 1, 1959Publication History Published online1 May 2002Published inissue 1 November 1959https://pubs.acs.org/doi/10.1021/jo01093a022https://doi.org/10.1021/jo01093a022research-articleACS PublicationsRequest reuse permissionsArticle Views264Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Evaluation of the catalytic activity of lipases immobilized on chrysotile for esterification (2003)

In the present work, the ester synthesis in organic media catalyzed by lipases immobilized on chrysotile was studied. Lipases of different sources (Mucor javanicus, Pseudomonas cepacia, Rhizopus oryzae, Aspergillus niger and Candida rugosa) were immobilized on chrysotile, an inexpensive magnesium silicate, and used for esterification of hexanoic, octanoic and lauric acid with methanol, ethanol, 1-butanol and 1-octanol at 25 C in hexane as solvent. The best results were obtained with Mucor javanicus lipase and lauric acid giving yields of 62-97% of ester.
Vectorizing line drawings with near-constant line width (2012)

Many line drawing images are composed of lines with near-constant width. Such line width information has seldom been used in the vectorization process. In this work, we show that by enforcing the near-constant line width constraint, we are able to produce visually more pleasing vectorization results. To this end, we develop a tracing-based approach, allowing dynamic validation of the line width constraint. The key here is to derive correct tracing directions, which are determined based on an automatically estimated orientation field, shape smoothness and the near-constant line width assumption. We have examined our algorithm on a variety of line drawing images with different shape and topology complexity. We show that our solution outperforms the state-of-the-art vectorization software systems including WinTopo and Adobe Illustrator, especially at regions where multiple lines meet and thus are difficult to locally distinguish from each other.
Dependency tree-based SRL with proper pruning and extensive feature engineering (2008)

This paper proposes a dependency tree-based SRL system with proper pruning and extensive feature engineering. Official evaluation on the CoNLL 2008 shared task shows that our system achieves 76.19 in labeled macro F1 for the overall task, 84.56 in labeled attachment score for syntactic dependencies, and 67.12 in labeled F1 for semantic dependencies on combined test set, using the standalone MaltParser. Besides, this paper also presents our unofficial system by 1) applying a new effective pruning algorithm; 2) including additional features; and 3) adopting a better dependency parser, MSTParser. Unofficial evaluation on the shared task shows that our system achieves 82.53 in labeled macro F1, 86.39 in labeled attachment score, and 78.64 in labeled F1, using MSTParser on combined test set. This suggests that proper pruning and extensive feature engineering contributes much in dependency tree-based SRL.
Size-Dependent Properties of Nanocrystalline Silicalite Synthesized with Systematically Varied Crystal Sizes (2004)

Silicalite-1 powders with crystal sizes ranging from 20 to 1000 nm were synthesized by systematically varying synthesis gel composition, pressure, temperature, and time duration. These samples were characterized by powder X-ray diffraction, scanning electron microscopy, nitrogen adsorption isotherms, solid-state nuclear magnetic resonance, and toluene adsorption. The effect of crystal size on the physical properties of crystals is observed, including a large increase of both total and external surface area when crystal size decreases. The relationship between particle size and external surface area was modeled by assuming a cubic crystal geometry. The nanosized silicalite samples with crystal sizes less than 100 nm have a higher adsorption capacity for toluene, showing promising potential for its application in volatile organic compound removal.
Effect of different oral hygiene measures on oral malodor in children aged 7-15 years (2015)

Oral malodor was significantly reduced after performing oral hygiene measures individually, but reduced more when used in combination.
Privacy in Pharmacogenetics: An End-to-End Case Study of Personalized Warfarin Dosing. (2014)

We initiate the study of privacy in pharmacogenetics, wherein machine learning models are used to guide medical treatments based on a patient's genotype and background. Performing an in-depth case study on privacy in personalized warfarin dosing, we show that suggested models carry privacy risks, in particular because attackers can perform what we call <i>model inversion</i>: an attacker, given the model and some demographic information about a patient, can predict the patient's genetic markers. As differential privacy (DP) is an oft-proposed solution for medical settings such as this, we evaluate its effectiveness for building private versions of pharmacogenetic models. We show that <i>DP mechanisms prevent our model inversion attacks when the privacy budget is carefully selected</i>. We go on to analyze the impact on utility by performing simulated clinical trials with DP dosing models. We find that for privacy budgets effective at preventing attacks, <i>patients would be exposed to increased risk of stroke, bleeding events, and mortality</i>. We conclude that <i>current</i> DP mechanisms do not simultaneously improve genomic privacy while retaining desirable clinical efficacy, highlighting the need for new mechanisms that should be evaluated <i>in situ</i> using the general methodology introduced by our work.
Unsupervised detection of available parking spots (2016)

In recent years, finding an available parking spot is becoming increasingly difficult, especially near crowded places. This leads to frustration and waste of time and fuel among many drivers. In this paper, we propose an efficient computer-vision algorithm for estimating parking availability, based on unsupervised learning of parking spot locations. The learning stage is based on analyzing the motion field due to car motion in parking areas, for estimating parking spot locations. A parametric curve is then fitted to the estimated locations, and parking spot centers are detected using the K-means algorithm. The status of each parking spot (i.e., vacant/occupied) is based on the distance of a detected entering/leaving car to the spot center. The algorithm was tested in several real-world scenarios, with no prior information on the parking spot location structure, exhibiting good detection performance.
Experience Talk of Crystalline Silicon Solar Cells' Peripharel Facilities Constrction (2012)

The 48th research institute of CETC is the first in crystalline silicon solar cells and the entire line of turnkey's organization,which has complete dozens of entire lines of solar energy's construction in China.The entire line construction include configuration of production line equipment,installation,peripheral facilities(plant design,cleanroom's construction and design of water,gas and electricity),process debugging,put into operation.The improtance of peripheral facilities is often ignored.I have assumed the design of severl entire lines,involved into design of peripheral facilities and track the whole process of construction at the site until the delivery of the entire line.Found some design problems in peripheral facilities could be modified and improved to share with everyone.
Design of a novel bearingless permanent magnet vernier slice motor with external rotor (2017)

This work presents a novel bearingless (slice) motor concept, the bearingless Vernier motor. It is intended for low speed and high torque applications, as typical for direct drives. Design criteria are deduced by the help of an analytic model describing single phase force and torque generation. The feasibility of the model is also proven by finite element simulations. Based on these results the performance of several bearingless permanent magnetic Vernier motor topologies with exterior rotor is evaluated. After that a bearingless Vernier motor prototype is optimized by 3D finite element simulations, designed and manufactured.
Development of a Plate-Based Optical Biosensor Fragment Screening Methodology to Identify Phosphodiesterase 10A Inhibitors (2013)

We describe the development of a novel fragment screening methodology employing a plate-based optical biosensor system that can operate in a 384-well format. The method is based on the "inhibition in solution assay" (ISA) approach using an immobilized target definition compound (TDC) that has been specifically designed for this purpose by making use of available structural information. We demonstrate that this method is robust and is sufficiently sensitive to detect fragment hits as weak as KD 500 μM when confirmed in a conventional surface plasmon resonance approach. The application of the plate-based screen, the identification of fragment inhibitors of PDE10A, and their structural characterization are all discussed in a forthcoming paper.
[Monitoring of vital patient's functions by contact-free sensors]. (2004)

An experimental device was constructed as well as hardware and software were designed to register the functional state parameters, i.e. external respiration functions, rhythmic heart activity and general motor activity (including the spastic and epileptic variations), when there is no direct galvanic contact with the patient's body.
Regulation of Interleukin-1β-induced Interleukin-6 Gene Expression in Human Fibroblast-like Synoviocytes by p38 Mitogen-activated Protein Kinase (1998)

Involvement of p38 mitogen-activated protein (MAP) kinase in interleukin (IL)-6 gene expression of human fibroblast-like synoviocytes (FLSs) was assessed. p38 MAP kinase was constitutively expressed in human FLSs and activated in response to IL-1beta. A pyridinylimidazole compound, SB203580, inhibited p38 MAP kinase activity in vivo, since the activity of MAPKAP kinase-2 (a substrate of p38 MAP kinase) in IL-1beta-stimulated FLSs was totally suppressed by it. SB203580 concentration-dependently inhibited protein production and gene expression of IL-6 by human FLSs. The effect of SB203580 was dependent on de novo protein synthesis. SB203580 significantly reduced the stability of IL-6 mRNA without affecting the rate of IL-6 gene transcription. Here, we provide evidence that p38 MAP kinase is activated in response to IL-1beta in human FLSs and is involved in IL-6 synthesis by stabilizing IL-6 mRNA.
The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3'-end formation. (1995)

Cleavage-polyadenylation specificity factor (CPSF) is a multisubunit protein that plays a central role in 3' processing of mammalian pre-mRNAs. CPSF recognizes the AAUAAA signal in the pre-mRNA and interacts with other proteins to facilitate both RNA cleavage and poly(A) synthesis. Here we describe the isolation of cDNAs encoding the largest subunit of CPSF (160K) as well as characterization of the protein product. Antibodies raised against the recombinant protein inhibit polyadenylation in vitro, which can be restored by purified CPSF. Extending previous studies, which suggested that 160K contacts the pre-mRNA, we show that purified recombinant 160K can, by itself, bind preferentially to AAUAAA-containing RNAs. While the sequence of 160K reveals similarities to the RNP1 and RNP2 motifs found in many RNA-binding proteins, no clear match to a known RNA-binding domain was found, and RNA recognition is therefore likely mediated by a highly diverged or novel structure. We also show that 160K binds specifically to both the 77K (suppressor of forked) subunit of the cleavage factor CstF and to poly(A) polymerase (PAP). These results provide explanations for previously observed cooperative interactions between CPSF and CstF, which are responsible for poly(A) site specification, and between CPSF and PAP, which are necessary for synthesis of the poly(A) tail. Also supporting a direct role for 160K in these interactions is the fact that 160K by itself retains partial ability to cooperate with CstF in binding pre-mRNA and, unexpectedly, inhibits PAP activity in in vitro assays. We discuss the significance of these multiple functions and also a possible evolutionary link between yeast and mammalian polyadenylation suggested by the properties and sequence of 160K.
Partial purification and characterization of protection‐inducing antigens from the muscle larva of <i>Trichinella spiralis</i> by molecular sizing chromatography and preparative flatbed isoelectric focusing (1981)

The soluble portion of a large particle fraction which was derived from the muscle larva of T. spiralis was subjected to molecular sizing column chromatography using Sephacryl S-200. Five major peaks of 280 nm absorbing material were obtained. Analysis by immunoelectrophoresis revealed that each peak contained antigens, with the majority of them occurring in peaks 3, 4 and 5. Preliminary studies indicated that peak 4(mol. wt range 20 000--10 000) contained protection-inducing antigens. Crossed-immunoelectrophoretic and single-dimension electrophoretic analysis of peak 4 revealed a minimum of 10 antigens, while analytical isoelectric focusing demonstrated the presence of proteins with widely different pl, ranging from 4.0 to 9.0. Peak 4 was fractionated by preparative flatbed isoelectric focusing (PIEF) using two gradients: one from 3.5 to 9.5 and the other from 3.5 to 5.5. Fused rocket immunoelectrophoretic (FRIEP) analysis of both runs indicated that several antigens were separated from the others: one at pl 4.0 and the other at pl 9.0. The remaining antigens focused between pl 4.3 and 4.9. One hundred micrograms of whole peak 4, pl 9.0 antigen and the group of antigens at pl 4.3--4.9 were each separately injected, along with Freund's complete adjuvant, into mice. In addition, a portion of the pl 4.0 antigen was also assayed for protection. All antigenic preparations induced significant levels of protection. The pl 4.0 was further analysed on high-performance liquid chromatography (HPLC). Two sharp peaks of antigen, as detected by FRIEP, were eluted isocratically with 65% acetonitrile from a C-18 (aliphatic) column. Both peaks of antigen showed complete cross-reactivity on FRIEP and absorbed at 220 nm. Amino acid analysis of each HPLC peak revealed no detectable differences in composition. Each peak contained predominance of aspartic (13 mol%) and glutamic (18 mol%) acid. This antigen did not contain significant quantities of aromatic amino acids, and absorbed strongly at 206 nm. Neither the pl 4.0 or pl 9.0 antigen stained positively with the PAS reaction.