gebhart/patrepeval huggingface dataset:
Use of a dynamic bubble trap in the arterial line reduces microbubbles during cardiopulmonary bypass and microembolic signals in the middle cerebral artery (2005)

Neurological complications remain an important cause of morbidity and mortality of patients following cardiopulmonary bypass (CPB). Microemboli, as well as cerebral hypoperfusion, are the main postulated mechanisms. This study demonstrates that the insertion of a dynamic bubble trap (DBT) into the curcuit reduces microbubbles in the arterial line and microembolic signals (MES) in the middle cerebral arteries (MCAs). We investigated 12 patients during coronary artery bypass grafting (CABG). The DBT was inserted between the arterial filter and the arterial cannula. For detection of microemboli before and after the DBT, a special ultrasound Doppler device was used. MES were detected by transcranial Doppler monitoring in both MCAs of the patients. Microbubbles and MES were counted during bypass. These data were compared to 12 patients who were operated in a previous period without the use of a DBT. There were no significant differences in both groups with respect to gender, age, crossclamp and bypass time and number of anastomoses. In the group without a DBT in the circuit, a mean of 6311 microbubbles per operation could be observed distal to the arterial filter, corresponding to 282 MES. After inclusion of a DBT, we could register, in the second group, 8496 microemboli proximal and 2915 distal of the DBT, corresponding to 89 MES per operation. The reduction rate of microbubbles in the tubing was 65.7%, corresponding to a reduction in MES of about 86.2%. We conclude that the insertion of a DBT in the arterial line of CPB circuit protects the cerebrovascular system from microembolic events, as demonstrated by lower MES counts.
MALDI In‐Source Photooxidation Reactions for Online Peptide Tagging (2008)

A TiO2 photoelectrode array has been designed to achieve efficient photoelectrochemical redox reactions with electron donors or acceptors during the laser desorption ionization process. By adding hydroquinone to a peptide mixture, the photoelectrochemically generated benzoquinone reacts with the cysteine residues to selectively form tagged cysteine-containing peptides, thus demonstrating that in-source oxidation reactions can be efficiently performed.
Body Cues, Not Facial Expressions, Discriminate Between Intense Positive and Negative Emotions (2012)

The distinction between positive and negative emotions is fundamental in emotion models. Intriguingly, neurobiological work suggests shared mechanisms across positive and negative emotions. We tested whether similar overlap occurs in real-life facial expressions. During peak intensities of emotion, positive and negative situations were successfully discriminated from isolated bodies but not faces. Nevertheless, viewers perceived illusory positivity or negativity in the nondiagnostic faces when seen with bodies. To reveal the underlying mechanisms, we created compounds of intense negative faces combined with positive bodies, and vice versa. Perceived affect and mimicry of the faces shifted systematically as a function of their contextual body emotion. These findings challenge standard models of emotion expression and highlight the role of the body in expressing and perceiving emotions.
Design and performance of a new pixelated- LSO/PSPMT gamma-ray detector for high resolution PET imaging (2007)

The gamma-ray detector developed for the Siemens Inveontrade small animal PET systems affords improved light collection and reduced number of photodetectors, while providing 67% greater axial field of view over the previous Focustrade system design. This is achieved using a tapered, multiple-element lightguide to couple the detector's 1.6 mm pitch, 20 times 20 LSO crystal array (32 mm square) to the 23.5 mm square photosensitive area of a Hamamatsu R8900 C12 PSPMT. The response of 900 production detectors to 511 keV photons has been analyzed. The average peak-to-valley ratio of crystal rows and columns derived from 2-d event position histograms was 4.08 plusmn 0.26 (plusmn1 SD; range of 2.96 to 5.60), and the average detector energy resolution derived from individual crystal spectra was 12.3 plusmn 0.5% FWHM (plusmn1 SD; range of 11.2% to 13.9%). Application of this compact detector in conjunction with the Quicksilvertrade electronics architecture enables flexible system design for high performance PET imaging.
Preparation of Dipyridamole Block Copolymer Micelle and Research of in Vitro Drug Release (2010)

The dipyridamole drug-loaded micelle was prepared with a novel block copolymer poly(sebacic anhydride)-poly(ethylene glycol)-poly(sebacic anhydride) by precipitation/solvent evaporation method.The diameter of micelle was measured by DLS.The UV-VIS method was used to study the drug loaded,drug-loading efficiency,and release rate of the dipyridamole micelle.The diameter of drug-loaded micelle was found larger than the corresponding drug-free micelle.The drug loaded and drug-loading efficiency increased with the increase of hydrophobic block in copolymer,as well as the drug release time.Different dipyridamole release profiles could be obtained with adjusting the composition of the block copolymers.
NDE of Decayed Wood with Ultrasonic CT (2006)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Phase imaging of moving DNA molecules and DNA molecules replicated in the atomic force microscope (1997)

Phase imaging with a tapping mode atomic force microscope (AFM) has many advantages for imaging moving DNA and DNA-enzyme complexes in aqueous buffers at molecular resolution. In phase images molecules can be resolved at higher scan rates and lower forces than in height images from the AFM. Higher scan rates make it possible to image faster processes. At lower forces the molecules are imaged more gently. Moving DNA molecules are also resolved more clearly in phase images than in height images. Phase images in tapping mode AFM show the phase difference between oscillation of the piezoelectric crystal that drives the cantilever and oscillation of the cantilever as it interacts with the sample surface. Phase images presented here show moving DNA molecules that have been replicated with Sequenase in the AFM and DNA molecules tethered in complexes with Escherichia coli RNA polymerase.
Reliability enhancement in high-performance MOSFETs by annular transistor design (2004)

The use of annular MOSFET design, which has demonstrated total-dose radiation immunity in CMOS circuits, can improve the hot-carrier reliability of CMOS circuits by reducing the drain electric field compared to conventionally designed MOSFETs. A theoretical analysis of the annular n-MOSFET in saturation verifies the reduction of the drain electric field in properly designed MOSFETs. Hot-carrier data for an enclosed 0.25-/spl mu/m n-MOSFET demonstrate an improvement in hot-carrier lifetime by more than 3x compared to a conventional device in the same technology.
Metal Vinylidenes in Catalysis (1998)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMetal Vinylidenes in CatalysisChristian Bruneau and Pierre H. DixneufView Author Information Université de Rennes, CNRS (UMR 6509), Laboratoire de Chimie de Coordination et Catalyse Campus de Beaulieu, 35042 Rennes Cedex, France Cite this: Acc. Chem. Res. 1999, 32, 4, 311–323Publication Date (Web):December 18, 1998Publication History Received7 July 1998Published online18 December 1998Published inissue 20 April 1999https://pubs.acs.org/doi/10.1021/ar980016ihttps://doi.org/10.1021/ar980016iresearch-articleACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views3401Altmetric-Citations455LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Catalysts,Hydrocarbons,Ligands,Metals,Vinylidene group Get e-Alerts
The Cell Death-Inducing Ability of Glycoprotein 120 from Different HIV Strains Correlates with Their Ability to Induce CD4 Lateral Association with CD95 on CD4+ T Cells (1999)

CD4 cross-linking by HIV gp120 triggers CD4+ T cell death. Several authors have suggested that this effect is mediated by CD95, but this possibility is debated by other authors. In a previous work, we found by co-capping that gp120(451) and gp120MN, but not gp120(IIIB), induce lateral association of CD4 with CD95 on the T cell surface. In this work, we used fluorescence resonance energy transfer to confirm that CD4/CD95 lateral association is induced by gp120(451), but not gp120(IIIB). Moreover, we found that gp120 ability to induce the CD4/CD95 association correlates with ability to induce cell death, since gp120(451) and gp120MN induced higher levels of cell death than did gp120(IIIB) in PHA-derived CD4+ T cell lines. CD95 involvement in gp120-induced cell death was confirmed by showing that gp120(451) and gp120MN did not induce death in CD4+ T cells derived from patients with autoimmune/lymphoproliferative disease (ALD) and decreased CD95 function. Cell death induced by gp120MN was inhibited by a recombinant CD95/IgG.Fc molecule blocking the CD95/CD95L interaction. However, inhibition was late and only partial. These data suggest that the gp120-induced CD4/CD95 association exerts a dual effect: an early effect that is independent of CD95L and may be due to direct triggering of CD95 by gp120, and a late effect that may be due to sensitization of CD95 to triggering by CD95L. In line with the former effect, cell treatment with gp120MN activated caspase 3 in the presence of Fas/IgG.Fc, which shows that cell death induced by gp120MN independently of CD95L uses the same pathway as CD95.
Characterization of network-wide anomalies in traffic flows (2004)

Detecting and understanding anomalies in IP networks is an open and ill-defined problem. Toward this end, we have recently proposed the subspace method for anomaly diagnosis. In this paper we present the first large-scale exploration of the power of the subspace method when applied to flow traffic. An important aspect of this approach is that it fuses information from flow measurements taken throughout a network. We apply the subspace method to three different types of sampled flow traffic in a large academic network: multivariate timeseries of byte counts, packet counts, and IP-flow counts. We show that each traffic type brings into focus a different set of anomalies via the subspace method. We illustrate and classify the set of anomalies detected. We find that almost all of the anomalies detected represent events of interest to network operators. Furthermore, the anomalies span a remarkably wide spectrum of event types, including denial of service attacks (single-source and distributed), flash crowds, port scanning, downstream traffic engineering, high-rate flows, worm propagation, and network outage.
19. Wanderungsbewegungen (2013)

Das Gebiet des heutigen Luxemburg ist uraltes Kulturland. Die ältesten Besiedlungsspuren führen weit in die Altsteinzeit zurück, und seit dem Einsetzen der schriftlichen Überlieferung – seit den Tagen der Treverer und Römer – über das Mittelalter und die Neuzeit hinweg ist eindrucksvoll belegt, wie die Menschen diese Kernregion Europas schätzen lernten, sie kultivierten und ihre Heimat seit dem 19. Jahrhundert schließlich zu einem modernen und souveränen Staat entwickelten. Doch verlief diese Entwicklung durch die Jahrhunderte keineswegs geradlinig und ohne Brüche. Begehrlichkeiten mächtiger Nachbarn, stürmische Phasen der europäischen Geschichte, innere Verwerfungen und die Barbarei des Nationalsozialismus haben Land und Leute nicht verschont und den Werdegang Luxemburgs geprägt. Michel Pauly zeichnet in diesem instruktiven kleinen Buch souverän den Weg Luxemburgs von seinen frühesten Anfängen bis in die Gegenwart nach und nimmt dabei konsequent auch die angrenzenden Länder und die unmittelbaren Nachbarregionen in den Blick.
Marijuana Toxicity: Heavy Metal Exposure Through State-Sponsored Access to “la Fee Verte” (2018)

Federally unregulated, marijuana growth organizations (MGOs) have now provided a path to exposures to the neurotoxicity of heavy metals. The lack of US Food and Drug Administration (FDA) and US Environmental Protection Agency (EPA) testing and oversight of the MGOs now threatens the public health. Agribusiness and botany experts proclaim the value of cannabis as a perfect rotating plant for phytoremediation programs to help scavenge heavy metals from soils prior to seeding the land for food product. Cannabis has a high affinity for soil contaminants without affecting its own heartiness. However, “legal” marijuana plots have burgeoned in the “Emerald Triangle” of Northern California, Oregon and Washington. According to the FDA’s toxicology program, the largest sources of heavy metals (HMs) are the environments surrounding abandoned or active mines. The history of gold, platinum, coal, and copper mining in these grow areas now threatens the end-user; the plants ability to “scrub the earth” of these highly toxic HMs provides main stream smoke contamination to the consumer. Published reports of cannabis users showing hearing loss and neurological changes to temporal lobe structures involved in audition as well as learning and memory. The apoptotic cascade of cytotoxic events initiated by heavy metals is linked to the progression of Alzheimer’s and Parkinson’s disease, as well as hearing loss related to brain stem and temporal lobe neurotoxicity.
Acousto-optic diffraction of guided optical waves in LiNbO3 (1973)

We report acousto-optic diffraction modulation of a guided optical wave in LiNbO3 by an acoustic surface wave. 250 mW of acoustic power produces 100% modulation of the zero-order beam.
Data Analysis and Graphics Using R – an Example-Based Approach (2009)

Discover what you can do with R! Introducing the R system, covering standard regression methods, then tackling more advanced topics, this book guides users through the practical, powerful tools that the R system provides. The emphasis is on hands-on analysis, graphical display, and interpretation of data. The many worked examples, from real-world research, are accompanied by commentary on what is done and why. The companion website has code and datasets, allowing readers to reproduce all analyses, along with solutions to selected exercises and updates. Assuming basic statistical knowledge and some experience with data analysis (but not R), the book is ideal for research scientists, final-year undergraduate or graduate-level students of applied statistics, and practising statisticians. It is both for learning and for reference. This third edition expands upon topics such as Bayesian inference for regression, errors in variables, generalized linear mixed models, and random forests.
<title>Spinel: where did it go?</title> (1997)

Polycrystalline magnesium aluminum oxide, transparent from 200 nanometers to 6 microns, offers a unique combination of optical and physical properties. A superior dome and window material in respect to rain and particle erosion, solar radiation, high temperatures and humidity; it is resistant to attack by strong acids, sea water, and jet fuels. Although it had been qualified for, and designed into several advanced UV/visible/IR optical systems, production of hot-pressed Spinel was stopped at Alpha Optical Systems in 1993 by the parent company Coors Ceramics. Development efforts on cold-pressed/sinter/HIP Spinel at RCS Technologies are reportedly stalemated at the present time. Therefore, there is no known significant effort directed toward the development of polycrystalline Spinel. however, the author is in contact with both domestic and foreign laboratories which have expressed a desire to develop the technology for transparent Spinel. Renewed development may begin during calendar year 1997. Because of the apparent continuing significant interest in Spinel this paper will review the properties of Spinel and will compare the most significant properties of Spinel with sapphire and aluminum oxynitride. The limitations of competing manufacturing processes, will be mentioned. Grinding and polishing considerations will be reviewed in respect to maximizing optical and structural properties.
High‐performance size‐exclusion chromatographic studies on polar components formed in sunflower oil used for frying (1992)

Thermoxidative and hydrolytic alterations of a sunflower oil used in sixty repeated and discontinuous deep‐fat fryings of potatoes were evaluated by column and high‐performance size‐exclusion (HPSE) chromatography. Successive fryings of potatoes in sunflower oil, without turnover of fresh oil during the performance of fryings, increased the level of total polar components in the oil from 3.75% to 27.28% (w/w). Triglyceride polymers, triglyceride dimers, oxidized triglycerides and diglycerides increased after sixty fryings 89.8, 21.8, 4.9 and 1.7 times, respectively. These increases were well correlated with the number of fryings. However, there was not significant correlation between levels of free fatty acids and the number of fryings. Polar compounds were highly (r=0.9691) and significantly ( P <0.01) correlated with triglyceride polymers and also highly (r=0.9969 and r=0.9738) and significantly ( P <0.01) with triglyceride dimers and oxidized triglycerides, respectively. Nevertheless polar compounds were not significantly correlated with free fatty acids. Data suggest that an intensive thermoxidative rather than a hydrolytic process takes place in experimental deep‐fat frying of potatoes.
Protein and mRNA Characterization in Human Colorectal Carcinoma Cell Lines with Different Metastatic Potentials (2007)

Metastasis, the important characteristic of malignant tumors, is closely associated with a series of changes in the expressions of genes and proteins. In this study, we compared mRNA and protein expressions in a pair of human colorectal carcinoma cell lines named SW620 and SW480 with different metastatic potentials by suppression subtractive hybridization and 2-dimensional gel electrophoresis combined with the matrix-assisted laser desorption/ionization time-of-flight mass spectrometer. After suppression subtractive hybridization and differential screening, 24 differentially expressed gene fragments were obtained, including 9 known genes and 15 novel genes. Nine known genes, such as Cytochrome C, Oxidase II and III, Serum amyloid A, Mitotic Control Protein dis3, Eukaryotic Translation Initiation Factor 4A, function in the process of growth and differentiation, transcription, apoptosis, signal transduction. Six novel genes were found to locate in chromosome 5. Northern blot further confirmed the results. For protein analysis, 16 significantly different protein spots were detected using 2-dimensional gel electrophoresis and peptide mass fingerprinting analysis. The results were confirmed by Western blot. The peptide mass fingerprintings of spots were then compared with the NCBI and SWISS PROT database. The differentially expressed proteins included Galectin-1, Annexin A1, Casein kinase 2, Cytochrome c oxidase subunit VIb, S-100D calcium-binding protein, which may be involved in cell differentiation and proliferation, signal transduction, cell adhesion and migration, and tumor evasion of immune responses. An analysis of these genes and proteins reiterated much of our understanding of the metastatic process and also offered some identified targets without previously characterized functions, especially the novel metastasis associated genes, to be further investigated. Moreover, the results of the phenotypic function-related expression mapping analysis at the mRNA and protein level revealed obvious complementarities, providing important clues for further study of the molecular mechanism of metastasis, metastasis control and possible targets for cancer gene therapy.
Ultrawideband Technology in Medicine: A Survey (2012)

The utilization of wireless technology in traditional medical services provides patients with enhanced mobility. This has a positive effect on the recovery speed of a person after major surgical procedures or prolonged illness. Ultrawideband (UWB) radio signals have inherent characteristics that make them highly suitable for less invasive medical applications. This paper surveys our own and related recent research on UWB technology for medical sensing and communications. Some research perspectives in the aforementioned topics are suggested too.
Optimization design and evaluation of parking route based on automatic assignment mechanism of parking lot (2017)

The congestion causes of parking lot were analyzed with causal chain method and a questionnaire about individual demand of parking users was carried out. The results show that more than 90% of the users hope parking spaces can be automatically assigned to them when it’s difficult to find a parking space. The layout principles of WiFi in parking lot were provided. The automatic assignment mechanism of parking lot was given considering the individual demand of parking users and the avoidance of traffic conflicts. Some attribute decision factors such as lane occupancy conditions, travel distance, walking distance, and the occupancy situation of parking space on both sides were selected and optimal parking lot assignment model was established. Optimal paths were calculated through Dijkstra algorithm, and the information about the assignment location and path was sent to the drivers’ cell phones. The driver’s compliance was evaluated by comparing the driver’s parking trajectory with system recommended path. Finally, a large parking lot in Beijing was taken as an example. The results can offer constructive suggestions on parking route design and parking assignment mechanism, which can make the use of the limited parking resources more effectively.
Short-step Synthesis of Chenodiol from Stigmasterol (2004)

Chenodiol is an important bile acid widely used for gallstone dissolution and cholestatic liver diseases. We succeeded in a short-step synthesis of chenodiol, starting from the safer phytosterol, stigmasterol.
Tau Structures (2016)

Tau is a microtubule-associated protein that plays an important role in axonal stabilization, neuronal development, and neuronal polarity. In this review, we focus on the primary, secondary, tertiary, and quaternary tau structures. We describe the structure of tau from its specific residues until its conformation in dimers, oligomers, and larger polymers in physiological and pathological situations.