gebhart/patrepeval huggingface dataset:
Pulmonary Dysfunction Is Common during a Cytomegalovirus Infection after Renal Transplantation even in Asymptomatic Patients: Possible Relationship with Complement Activation (1987)

In 24 patients with a cadaveric renal allograft, serial measurements after transplantation were made of the diffusing capacity for carbon monoxide (DLCO) together with serial measurements of C3d, the stable conversion product of the complement factor C3, and determinations of the anaphylatoxin C3a. Twelve patients were studied during an active cytomegalovirus (CMV) infection, and 12 patients were studied during allograft rejection or during a stable phase after renal transplantation (control subjects). No patients had pulmonary symptoms nor abnormal chest radiographs or arterial blood gas determinations. During an active CMV infection, DLCO was significantly reduced compared with the measurements made during allograft rejection or during a stable phase after renal transplantation. This was true both with (p less than 0.01) and without (p less than 0.01) correction for the hemoglobin concentration. Serum C3d levels were increased in 8 of the 12 patients with a CMV infection, but not in any of the patients in the control group. In 8 patients with a CMV infection, measurements were made of the anaphylatoxin C3a, and were found to be significantly higher than the levels in the control population (p less than 0.01). We conclude that our data are consistent with pulmonary dysfunction in every patient with an active CMV infection. The concomitant findings of complement activation and formation of anaphylatoxins suggest a causal relationship of the complement activation and a decreased DLCO, although further studies are warranted to determine the exact role of complement in the pulmonary events during an active CMV infection after renal transplantation.(ABSTRACT TRUNCATED AT 250 WORDS)
Effect of pH on Lipid Oxidation Using Trout Hemolysate as a Catalyst:  A Possible Role for Deoxyhemoglobin (2000)

Hemoglobin-mediated lipid oxidation was studied by adding hemolysate to washed cod muscle. Three pH values were examined (pH 7.6, 7.2, and 6.0). The lag time prior to rancidity and thiobarbituric acid reactive substance development decreased greatly as the pH was reduced (p < 0.01). Formation of methemoglobin due to autoxidation of the heme pigment was found to occur more rapidly at reduced pH. Also, the level of deoxyhemoglobin was found to sharply increase with pH reduction in the range of pH 7.6-6.0. This suggested a potential role for deoxyhemoglobin as a catalyst. ATP lowered hemoglobin oxygenation at pH 7.2. Peroxidation of linoleic acid by oxy/deoxyhemoglobin and methemoglobin was investigated at two levels of preformed lipid hydroperoxides. At a reduced level of preformed lipid hydroperoxides, oxy/deoxyhemoglobin stimulated peroxidation of linoleic acid, whereas methemoglobin did not. At the higher level of preformed lipid hydroperoxides, both oxy/deoxyhemoglobin and methemoglobin were active. This investigation suggests that reduced hemoglobins played an important role in lipid oxidation processes.
[Combined effect of PT-050 (recombinant human TNF) and antitumor drugs on syngeneic murine tumors]. (1986)

The combined effect of PT-050 (recombinant human TNF) and various antitumor drugs was investigated using murine colon 26 adenocarcinoma, Meth A sarcoma and B16 melanoma transplanted into syngeneic mice. When colon 26- or Meth A- bearing mice were intravenously given PT-050 in combination with mitomycin C (MMC), doxorubicin (DXR), cis-platinum (CDDP), 5-fluorouracil (5-FU) or cyclophosphamide (CPA), a significant synergistic effect was observed, that is, both the inhibition rate of tumor growth and the cured ratio were increased significantly when compared with those given each drug alone. Similarly, an augmentation of the antitumor effect was also observed in B16-bearing mice by a combined treatment with PT-050 and these antitumor drugs. These results suggest that the combination chemotherapy of PT-050 with various antitumor drugs may be useful for cancer therapy.
An epitope within the DNA-binding domain of the herpes simplex virus immediate early protein Vmw175 is conserved in the varicella-zoster virus gene 62 protein (1993)

We have isolated a panel of monoclonal antibodies that recognize the DNA-binding domain of the herpes simplex virus type 1 (HSV-1) immediate early polypeptide Vmw175. The mice used for the fusions had been immunized with the isolated Vmw175 DNA-binding domain. This had been purified from bacteria that carried a phage T7 expression plasmid with the DNA-binding domain coding region. The epitopes recognized by the monoclonal antibodies were mapped by using a family of truncated versions of the DNA-binding domain, which had also been expressed in the bacterial expression system. The monoclonal antibodies divided into at least four different groups according to this mapping. Several of the monoclonal antibodies recognized Vmw175 expressed in infected BHK cells by HSV-1 strain 17 in Western blots. One of them also recognized the corresponding protein of varicella-zoster virus gene 62. This is further illustration of the relatedness of the two polypeptides.
Aeroallergens in Dairy Barns near Cooperstown, New York and Rochester, Minnesota (1989)

We sampled atmospheric barn air using a volumetric air sampler in ten barns near Cooperstown, NY and six barns near Rochester, MN, and, with radioimmunoassays, measured allergens of Aspergillus fumigatus, Thermoactinomyces vulgaris, Micropolyspori faeni, short ragweed, rye grass group I pollen, Alternaria (Alt-1), Dermatophagoides sp. Lepidoglyphus destructor, common insect allergen, mouse urine, rat urine, and cattle epithelium. The most abundant allergen present was A. fumigatus followed by L. destructor. This study provides initial data on barn aerobiology and demonstrates for the first time the abundance of L. destructor allergens in North American dairy barns. More comprehensive study of barns, poultry houses, confinement houses for swine, and other agricultural environments from various geographic locations is needed to define the allergen levels to which millions of farm workers are exposed each day. While most of the allergens were expected, the presence of airborne allergens reactive with antisera to Dermatophagoides suggests indirectly that substantial amounts of pyroglyphid mites are present in some barns.
OPTIMAL STOCKING OF RETAIL OUTLETS: THE CASE OF WEEKLY DEMAND PATTERN (2014)

Retail stores sell products to consumers. Their ability to sell depends upon the availability of the planned assortment, i.e. every item is on shelf so that the consumer can buy it. In particular, for fast moving consumer goods, like food, the consumer expects that each item is on stock. The retailer's decisions on the length of replenishment cycles of stores, on the shelf-capacity allocated to each item, on the amount of inventory stored in the backroom of the store, on the minimum order quantity of each item, or on the case size affect the fill rate of the store. This paper identifies a new aspect: With a demand fluctuating regularly according to a weekly pattern, the decision on which day to review inventory and to deliver stock has impact on the service level of the store. It analyzes the effect of the position of ordering cycles with respect to demand cycles on the out-of-stock rate. We simulate a retail scenario with different replenishment cycles, i.e. supermarkets with weekly seasonal demandccan be supplied at different days of the week. We show -based on actual sales data of supermarkets– that the fillrate depends heavily on the interaction between the weekly demand pattern and the inventory review and replenishment cycle. Futhermore, we demonstrate the role of item's case size in the performance of the supply chain. Numerical results for a periodic review, order-up-to-level inventory control system with batch-ordering and time-varying demand are presented.
Cesium and Strontium Separation Technologies Literature Review (2004)

Integral to the Advanced Fuel Cycle Initiative (AFCI) Program’s proposed closed nuclear fuel cycle, the fission products cesium and strontium in the dissolved spent nuclear fuel stream are to be separated and managed separately. A comprehensive literature survey is presented to identify cesium and strontium separation technologies that have the highest potential and to focus research and development efforts on these technologies. Removal of these high-heat-emitting fission products reduces the radiation fields in subsequent fuel cycle reprocessing streams and provides a significant short-term (100 yr) heat source reduction in the repository. This, along with separation of actinides, may provide a substantial future improvement in the amount of fuel that could be stored in a geologic repository. The survey and review of the candidate cesium and strontium separation technologies are presented herein. Because the AFCI program intends to manage cesium and strontium together, technologies that simultaneously separate both elements are of the greatest interest, relative to technologies that separate only one of the two elements.
<title>Impedance based flow sensor</title> (2005)

Microfluidic analysis devices, often referred to as Micro Total Analysis Systems or the Lab-on-a-chip, are often based on the manipulation of small volumes of fluid. These devices require the design and fabrication of components for fluid handling, control and measurement, such as micropumps, micromixers and flow sensors. The fabrication of miniature versions of large scale components such as pressure sensors and flow rate meters has been demonstrated. However, complicated fabrication is prohibitive and devices which involve flow constriction can be prone to blocking if particle containing samples are used. This paper presents results of the design and fabrication of a microimpedance measurement cell, designed to measure the impedance of sub-nanolitre volumes of fluids. The measurement system was designed to measure the electrical impedance at several different frequencies, allowing identification and analysis of the material contained within the sample volume. Measurements of different fluids at different flow rates through a microchannel containing the measurement cell are presented. The use of this system as a solid state flow rate sensor is then discussed.
Associations of the University Learning Environment with Academic Engagement and Satisfaction among Science Majors in Taiwan (2011)

The research described in this paper investigated science students' perceptions of their university learning environments and associations of these perceptions with their academic engagement and satisfaction. Data were collected from 1,169 junior students majoring in science from 17 universities in Taiwan. The quantitative research incorporated factor analysis, higher order factor structure, and hierarchical multiple regression analyses. The results revealed science students' diverse views of various environmental aspects and identified key aspects influencing the outcome measures, after controlling for student background and institutional characteristics. Faculty-student relation was the aspect that most strongly affected both academic engagement and learning satisfaction of these science students. Perceived adequacy of library resources, student services, enhancement of science capacities and language abilities, and relations with faculty were all positively related to the overall satisfaction of science students with their universities. By exploring potential influences of academic environment, the study contributes to a better understanding of the nature and intricate impact of the learning environment on the performance of undergraduate science majors in Taiwan and the need for reflection and improvement.
Effect of N2O plasma treatment on the stabilization of water absorption in fluorinated silicon-oxide thin films fabricated by electron-cyclotron-resonance plasma-enhanced chemical-vapor deposition (2002)

The variation of residual stress with the water absorption was reduced drastically by the N2O plasma treatment for fluorinated silicon-oxide thin films. Fourier transformed infrared spectroscopy analysis showed that the film was oxidized by the plasma treatment. It was also determined that the oxidation occurred on the film surface from the P-etch rate and x-ray photoelectron spectroscopy analysis. The experimental results show that the stabilization results from the oxidation of the surface by the N2O plasma treatment.
Some Studies on Water-Extended Polyester (1986)

Three unsaturated polyester resins were prepared and used with styrene monomer to produce water composites. The emulsion stability of the water- extended polyesters using different concentrations of triethanol amine as an emulsifier was studied. The water content and the mechanical properties of the cured composites were also investigated.
Expanding Advanced Production Logging Operations to Short Radius Horizontal Wells (2005)

Abstract This paper discusses the first successful coiled-tubing-conveyed production logging operation in a short radius horizontal well in Saudi Arabia. The production logging tool (Polaris[TM]) was modified with knuckle joints to pass through the severe well dogleg of 58 degrees per 100 ft in openhole. Subsequently, the tool was conveyed an additional 1400 ft in the horizontal section. The logging objective was to determine the flow profile for oil and water and identify the water entry points. The major challenge was tool deployment in this short radius well to gain access to the horizontal section. Monitoring of short radius horizontals has been almost nonexistent due to high dogleg severity. Because of the rigid tool length of conventional production logging systems, tool modifications were crucial and extensive job planning preceded the operations. Planning included modeling maximum rigid tool length, tool modifications, simulations for job feasibility with 1.75 in coiled tubing, and tool string bending moment tests. Prior to the main run, a dummy tool was successfully conveyed through the high dogleg to determine the feasibility of the operation. The successful completion of the log allowed the generation of a flow profile and identification of the major fluid entry poiints. These will help determine the most efficient way of sidetracking wells in the Ghawar Field to maximize reservoir sweep efficiency and to aid in planning future short radius horizontal wells.
High resolution preparative isoelectric focusing in layers of granulated gels (1982)

Abstract Discontinuous isoelectric focusing in layers of granulated gels is used to separate up to 1000 mg protein with a resolution of 0.01‐0.015 pI. High resolution is achieved with (i) gel layers of reduced thickness (1 mm), (ii) high field strength in the final stage of focusing (100‐200 V/cm), (iii) long separation distances, and (iv) high Volthour (Vh) products ensuring steady state conditions. We describe approaches to rapid focusing based on either short separation distances or extensive prefocusing with resultant short residence times of the separated substances in the gel. The optimum load capacity is 3‐5 mg protein/ml gel‐bed volume while 10 mg protein/ml gle‐bed volume are still well tolerated. At high loading, major components are seen in the gel as transulcent zones which can be easily identified and harvested. Best results are obtained with Sephadex G‐200 (Superfine) or Bio‐Gel P‐60 (minus 400 mesh). Protein visualization with a new printing technique empolying cellulose acetate membranes requires only 2‐3 min and is insensitive to protein overloading and adhering gel particles. A simple and efficient method is described for the electrophoretic removal of carrier ampholytes from the focused proteins. High resolution preparative isoelectric focusing should prove attractive for many applications due to its great flexibility with respect to sample size, gel volume, separation time, protein recovery, ease of operation and reasonable price.
Introduction (1989)

The past few years have seen many changes in nursing, nurse education and the management of the health service. The law that governs these areas has also been developing. The need for all nurses to appreciate and understand the role and potential contribution of the law has become obvious. This book hopes to meet that need, but it aims to go much further. Many nurses respond to the law with anxiety, because it is complex and uncertain, because it conjures up images of courts and civil or criminal liability, and for many other reasons. A better understanding of the law can relieve this anxiety and help both nurses and their patients.
Introduction (1998)

The year 1995 marked the fiftieth anniversary of the end of World War II. Scholars in the former Soviet Union greeted this watershed with a renewed interest in the war and its importance in the development of the Soviet Union. Wars have traditionally been the pivot points of history, and the two world wars are well suited for this role, involving as they did the mobilization of huge portions of the populations of the countries involved. World War II—or the Great Patriotic War, as the eastern front is known in the former Soviet Union—played a particularly significant role in Soviet history. The victory over Germany was used to justify all aspects of Stalinism, including rapid industrialization and collectivization, as well as the socialist system in general. The mobilization of troops for the front and workers for the war industry combined with the enormous evacuation of European Russia to create unprecedented demographic changes that have affected the Soviet economy, social structure, and culture to the present day. Soviet dominance of Eastern Europe and involvement in world diplomacy as a superpower had profound consequences not only for world diplomacy but also for the internal workings of the Soviet Union and, it has been argued, for its eventual demise.
Synthesis and Insecticidal Activity of 4-Substituted 1-Indanyl Chrysanthemates (1978)

A variety of 4-substituted 1-indanyl chrysanthemates were prepared and their insecticidal activity was tested on American cockroachs. The activity of the chrysanthemates decreased in the following order: CH2=CHCH2>CH3OCH2≃CH3CH2≃HC≡CCH2>PhCH2, which was similar to that of p-substituted benzyl chrysanthemates against houseflies with the exception of the propargyl group. Formulation of the quantative structure-activity relationship by the Hansch’s program indicated that Van der Waals interaction between the chemical substance and the macromolecular in vivo play an important role in the 1-indanyl chrysanthemates.
Purification Procedures for Single-Wall Carbon Nanotubes (2001)

This report summarizes the comparison of a variety of procedures used to purify carbon nanotubes. Carbon nanotube material is produced by the arc process and laser oven process. Most of the procedures are tested using laser-grown, single-wall nanotube (SWNT) material. The material is characterized at each step of the purification procedures by using different techniques including scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), transmission electron microscopy (TEM), Raman, X-ray diffractometry (XRD), thermogravimetric analysis (TGA), nuclear magnetic resonance (NMR), and high-performance liquid chromatography (HPLC). The identified impurities are amorphous and graphitic carbon, catalyst particle aggregates, fullerenes, and hydrocarbons. Solvent extraction and low-temperature annealing are used to reduce the amount of volatile hydrocarbons and dissolve fullerenes. Metal catalysts and amorphous as well as graphitic carbon are oxidized by reflux in acids including HCl, HNO3 and HF and other oxidizers such as H2O2. High-temperature annealing in vacuum and in inert atmosphere helps to improve the quality of SWNTs by increasing crystallinity and reducing intercalation.
Reverse Engineering Molecular Hypergraphs (2013)

Analysis of molecular interaction networks is pervasive in systems biology. This research relies almost entirely on graphs for modeling interactions. However, edges in graphs cannot represent multiway interactions among molecules, which occur very often within cells. Hypergraphs may be better representations for networks having such interactions, since hyperedges can naturally represent relationships among multiple molecules. Here, we propose using hypergraphs to capture the uncertainty inherent in reverse engineering gene-gene networks. Some subsets of nodes may induce highly varying subgraphs across an ensemble of networks inferred by a reverse engineering algorithm. We provide a novel formulation of hyperedges to capture this uncertainty in network topology. We propose a clustering-based approach to discover hyperedges. We show that our approach can recover hyperedges planted in synthetic data sets with high precision and recall, even for moderate amount of noise. We apply our techniques to a data set of pathways inferred from genetic interaction data in S. cerevisiae related to the unfolded protein response. Our approach discovers several hyperedges that capture the uncertain connectivity of genes in relevant protein complexes, suggesting that further experiments may be required to precisely discern their interaction patterns. We also show that these complexes are not discovered by an algorithm that computes frequent and dense subgraphs.
Essentials of Systems Analysis and Design (2000)

From the Publisher:

SDLC Framework


Central to the development of an efficient information system is the systems development life cycle (SDLC). Each chapter opens with an SDLC figure with parts highlighted to show students how each chapter, and each SDLC phase, systematically builds on the other. We highlight four key SDLC steps: Planning and Selection; Analysis; Design; Implementation and Operations.


Internet Coverage and Features


Electronic Commerce Application: Pine Valley Furniture WebStore: A furniture company founded in 1980 has decided to explore electronic commerce as an avenue to increase its market share. Should this company sell its products online? How would a team of analysts work together to develop, propose, and implement a plan? Beginning in Chapter 3, we explore the step-by-step process.

Broadway Entertainment Company, Inc.: This end-of-chapter case illustrates how a fictional video and record retailer develops a Web-based customer relationship management system. This case first appears at the end of Chapter 2 and concludes at the end of Chapter 10.

Net Search: Each chapter includes a boxed margin feature entitled Net Search. 

Three Illustrative Fictional Cases


Pine Valley Furniture: This case is introduced in Chapter 2 and revisited throughout the book. As key concepts are presented, they are applied and illustrated with this case.

Hoosier Burger: Starting in Chapter 5, we use this case of a fast food restaurant to illustrate how analysts would develop andimplement an automated food ordering system.

Broadway Entertainment Company, Inc.: This video rental and music company extended case the illustrates key chapter concepts.
On physical models for gate oxide breakdown (1984)

Electrical breakdown of thin (32-nm) SiO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> films subjected to constant-current stressing is studied. By studying the effects of reversing the polarity of the constant-current bias and the effects of thermal annealing on the charge-to-breakdown it is determined that electrical breakdown of SiO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> is not caused by the widely-cited accumulation of trapped electrons. Rather it is caused by the buildup of positive charges near the cathode at localized areas. The positive charges are not mobile ions but exhibit many characteristics of trapped holes. We conclude that electrical breakdown in SiO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> is caused by the accumulation of holes, generated by impact ionization in the oxide.