gebhart/patrepeval huggingface dataset:
Dual‐Mode Luminescent Colloidal Spheres from Monodisperse Rare‐Earth Fluoride Nanocrystals (2009)

Monodisperse rare-earth fluoride nanocrystals are synthesized and used as building blocks to fabricate dual-mode luminescent colloidal spheres, which are composed of two distinct units, one offering down-converting luminescence under UV excitation and the other providing up-converting luminescent emission when excited with a 980 nm laser, and have potential applications in multiplexed and highly sensitive bioassays.
PURIFICATION OF OVARIAN THECA-INTERSTITIAL CELLS BY DENSITY GRADIENT CENTRIFUGATION (1988)

The study of the biochemical mechanisms regulating the differentiation of the ovarian androgen-producing cells has been difficult because of the lack of a method for isolating the theca-interstitial cells (TIC) from the granulosa and other cell types. We report here a simple, rapid and reproducible method for obtaining large numbers of highly enriched TIC using density gradient centrifugation. When dispersed cells from ovaries of hypophysectomized immature rats were centrifuged in a Percoll gradient (20-70%), the cells were separated into five incompletely resolved bands. Of these, band V contained the androgen-producing cells. The band V cells produced 3.2- and 3.9-fold more cAMP and androgen, respectively, than the whole ovarian cells and contained 3.8- and 3.5-fold more 125I-hCG binding and 3 beta-HSDH labeled cells, respectively. These data indicated that the TIC were 65% pure. In order to improve the degree of purification, a discontinuous density procedure was used. When the ovarian cells were centrifuged in d = 1.055 g/ml Percoll, the purified TIC produced 4.7- and 5.9-fold more cAMP and androgen than the whole ovarian cells and they contained 5.3-fold more 125I-hCG binding. The TIC were cleanly separated from the granulosa cells and histochemical staining for 3 beta-HSDH activity revealed that the TIC were 93.0 +/- 1.3% pure. This method provides, for the first time, the opportunity to study TIC differentiation under defined conditions without granulosa cell contamination.
Neurostimulation for Primary Headache Disorders, Part 1: Pathophysiology and Anatomy, History of Neuromodulation in Headache Treatment, and Review of <i>Peripheral</i> Neuromodulation in Primary Headaches (2011)

Neurostimulation for primary headaches is being increasingly utilized as a treatment modality. Use of neuromoduation has generated multiple case reports as well as some controlled studies. This article is the first of 2 systematic reviews of available data regarding neurostimulation for primary headache conditions. The pathophysiology, relative anatomy, theoretical mechanisms, and history of neurostimulation for primary headache are covered in this section, Part 1 of 2. The literature regarding peripheral neurostimulatory targets is also reviewed in Part 1. These peripheral targets include: percutaneous nerves, transcranial holocephalic, occipital nerves, auriculotemporal nerves, supraorbital nerves, cervical epidural, and sphenopalatine ganglia. Part 2 will focus on central stimulation, covering vagus nerve, and deep brain stimulation. Part 2 also contains an overall analysis of efficacy, safety, cost, patient selection, and suggestions for further study based on available evidence.
Gefässerweiternde Stoffe der Gewebe (1936)

La Real Academia Nacional de Medicina de España, cuya historia comienza hacia mediados del siglo XVIII, posee una magnífica biblioteca con manuscritos e impresos, indispensables para el estudio e investigación de la historia de la medicina en España. Para dar la mayor visibilidad posible y hacerlo accesible a los estudiosos, investigadores y ciudadanos en general, se crea esta Biblioteca Digital de la Real Academia Nacional de Medicina de España.
An adaptive KLT approach for speech enhancement (2001)

An adaptive Karhunen-Loeve transform (KLT) tracking-based algorithm is proposed for enhancement of speech degraded by colored additive interference. This algorithm decomposes noisy speech into its components along the axes of a KLT-based vector space of clean speech. It is observed that the noise energy is disparately distributed along each eigenvector. These energies are obtained from noise samples gathered from silence intervals between speech samples. To obtain these silence intervals, we proposed an efficient voice activity detector based on outputs of the principle component eigenfilter; the greatest eigenvalue of speech KLT. Enhancement is performed by modifying each KLT component due to its noise and clean speech energies. The objective is to minimize the produced distortion when residual noise power is limited to a specific level. At the end, the inverse KLT is performed and an estimation of the clean signal is synthesized. Our listening tests indicated that 71% of our subjects preferred the enhanced speech by the above method over former methods of enhancement of speech degraded by computer generated white Gaussian noise. Our method was preferred by 80% of our subjects when we processed real samples of noisy speech gathered from various environments.
Full Spectrum Raman Excitation Mapping Spectroscopy (2020)

A generalization of the Raman scattering (RS) spectrum, the Raman excitation map (REM) is a hyperspectral two-dimensional (2D) data set encoding vibrational spectra, electronic spectra and their coupling. Despite the great potential of REM for optical sensing and characterization with remarkable sensitivity and selectivity, the difficulty of obtaining maps and the length of time required to acquire them has been practically limiting. Here we show, with a simple setup using current optical equipment, that maps can be obtained much more rapidly than before (~ms to ~100 s now vs. ~1000 s to hours before) over a broad excitation range (here ~100 nm is demonstrated, with larger ranges straightforward to obtain), thus taking better advantage of scattering resonance. We obtain maps from different forms of carbon: graphite, graphene, purified single walled carbon nanotubes (SWCNTs) and chirality enriched SWCNTs. The relative speed and simplicity of the technique make REM a practical and sensitive tool for chemical analysis and materials characterization.
Defying Gravity: An Interview with Dennis Altman on the 30th Anniversary of Homosexual: Oppression and Liberation (2000)

Dennis Altman has been one of the leading activists and writers in the Gay Movement since the publication of his highly influential book Homosexual: Oppression and Liberation 30 years ago. In this interview, he is asked about his contributions to the lesbian and gay movement, his contemporary appraisals of the movement, and his thoughts on globalization and the future.
Engine nacelles design – Problems and challenges (2017)

This paper presents a design approach for large passenger aircraft nacelles. It describes nacelle functions, configurations, and major components. Design criteria for particular components of the nacelle are presented. Typical materials used for structure build including composites are elaborated. Certification requirements are shown. The paper presents challenges for nacelle design and build, including weight, aerodynamic smoothness, nacelle integration, and cost.
Bioinspired Transparent Laminated Composite Film for Flexible Green Optoelectronics (2017)

Herein, we report a new version of a bioinspired chitin nanofiber (ChNF) transparent laminated composite film (HCLaminate) made of siloxane hybrid materials (hybrimers) reinforced with ChNFs, which mimics the nanofiber-matrix structure of hierarchical biocomposites. Our HCLaminate is produced via vacuum bag compressing and subsequent UV-curing of the matrix resin-impregnated ChNF transparent paper (ChNF paper). It is worthwhile to note that this new type of ChNF-based transparent substrate film retains the strengths of the original ChNF paper and compensates for ChNF paper's drawbacks as a flexible transparent substrate. As a result, compared with high-performance synthetic plastic films, such as poly(ethylene terephthalate), poly(ether sulfone), poly(ethylene naphthalate), and polyimide, our HCLaminate is characterized to exhibit extremely smooth surface topography, outstanding optical clarity, high elastic modulus, high dimensional stability, etc. To prove our HCLaminate as a substrate film, we use it to fabricate flexible perovskite solar cells and a touch-screen panel. As far as we know, this work is the first to demonstrate flexible optoelectronics, such as flexible perovskite solar cells and a touch-screen panel, actually fabricated on a composite film made of ChNF. Given its desirable macroscopic properties, we envision our HCLaminate being utilized as a transparent substrate film for flexible green optoelectronics.
Struma ovarii associated with pseudo-Meigs' syndrome and elevated serum CA 125: a case report and review of the literature (2010)

The association of pseudo-Meigs' syndrome, elevation of CA 125 to the struma ovarii is a rare condition. So far only nine cases have been reported in English literature through MEDLINE search. Here we report a 46-year-old case of the struma ovarii, presented with ascites, hydrothorax, right ovarian mass and elevated serum CA 125 level. These findings were misdiagnosed for an ovarian malignancy at the first impression. Immediate resolution of the ascites, hydrothorax and normalization of the serum CA 125 level were followed by ovarian mass removal. Struma ovarii could be a rare cause of ascites, hydrothorax, ovarian mass and elevated CA 125. This rare condition should be considered in the differential diagnosis in patents with ascites and pleural effusions but with negative cytology.
Pyrimidine acyclic nucleosides. 1-[(2-Hydroxyethoxy)methyl]pyrimidines as candidate antivirals (1981)

A number of pyrimidine acyclic nucleosides were synthesized and tested for activity against herpes simplex virus type 1. Synthesis of 1-[(2-hydroxyethoxy)methyl]cytosine (8) and 1-[(2-hydroxyethoxy)methyl]uracil (14) was accomplished in two or three steps from 2,4-diethoxypyrimidine and 2-(benzoyloxy)ethoxymethyl chloride. The 5-methyl (20), 5-(trifluoromethyl) (21), and 5-fluoro (22) analogues of 14 were available in two steps form the appropriate bis(trimethylsilyl)ated 5-substituted uracil and 2-(acetoxymethoxy)ethyl acetate or 2-(benzoyloxy)ethoxymethyl chloride. Bromination of 8 and 14 or iodination of 14 gave the 5-halogeno-1-[(2-hydroxyethoxy)methyl]pyrimidines 9, 23, and 24. These pyrimidine acyclic nucleosides exhibited little or no activity against herpes simplex virus type 1 or against a range of other DNA and RNA viruses. This is compatible with their lack of substrate properties toward herpes simplex virus induced thymidine kinase.
Mutational Definition of RNA-binding and Protein-Protein Interaction Domains of Heterogeneous Nuclear RNP C1 (2001)

The heterogeneous nuclear ribonucleoprotein (hn- RNP) C proteins, among the most abundant pre-mRNA-binding proteins in the eukaryotic nucleus, have a single RNP motif RNA-binding domain. The RNA-binding domain (RBD) is comprised of approximately 80-100 amino acids, and its structure has been determined. However, relatively little is known about the role of specific amino acids of the RBD in the binding to RNA. We have devised a phage display-based screening method for the rapid identification of amino acids in hnRNP C1 that are essential for its binding to RNA. The identified mutants were further tested for binding to poly(U)-Sepharose, a substrate to which wild type hnRNP C1 binds with high affinity. We found both previously predicted, highly conserved residues as well as additional residues in the RBD to be essential for C1 RNA binding. We also identified three mutations in the leucine-rich C1-C1 interaction domain near the carboxyl terminus of the protein that both abolished C1 oligomerization and reduced RNA binding. These results demonstrate that although the RBD is the primary determinant of C1 RNA binding, residues in the C1-C1 interaction domain also influence the RNA binding activity of the protein. The experimental approach we described should be generally applicable for the screening and identification of amino acids that play a role in the binding of proteins to nucleic acid substrates.
PTP1B regulates Eph receptor function and trafficking (2010)

Eph receptors orchestrate cell positioning during normal and oncogenic development. Their function is spatially and temporally controlled by protein tyrosine phosphatases (PTPs), but the underlying mechanisms are unclear and the identity of most regulatory PTPs are unknown. We demonstrate here that PTP1B governs signaling and biological activity of EphA3. Changes in PTP1B expression significantly affect duration and amplitude of EphA3 phosphorylation and biological function, whereas confocal fluorescence lifetime imaging microscopy (FLIM) reveals direct interactions between PTP1B and EphA3 before ligand-stimulated receptor internalization and, subsequently, on endosomes. Moreover, overexpression of wild-type (w/t) PTP1B and the [D-A] substrate-trapping mutant decelerate ephrin-induced EphA3 trafficking in a dose-dependent manner, which reveals its role in controlling EphA3 cell surface concentration. Furthermore, we provide evidence that in areas of Eph/ephrin-mediated cell-cell contacts, the EphA3-PTP1B interaction can occur directly at the plasma membrane. Our studies for the first time provide molecular, mechanistic, and functional insights into the role of PTP1B controlling Eph/ephrin-facilitated cellular interactions.
Two-Dimensional White Light Coherence Interferometer (1974)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text James B. Breckinridge, "Two-Dimensional White Light Coherence Interferometer," Appl. Opt. 13, 2760-2762 (1974) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
New S&T Director at ONR (2002)

Share Icon Share Twitter Facebook Reddit LinkedIn Reprints and Permissions Cite Icon Cite Search Site Citation Jim Dawson; New S&T Director at ONR. Physics Today 1 September 2002; 55 (9): 33. https://doi.org/10.1063/1.2408491 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentPhysics Today Search Advanced Search
Chromium Transformations in Natural Environments: The Role of Biological and Abiological Processes in Chromium(VI) Reduction (2000)

Chromium is a redox-dynamic element that has many industrial uses. As a consequence, it is often introduced at elevated levels into the surface environment through human activity. Additionally, ultramafic rocks such as serpentinite are commonly enriched in chromium, and thus can also lead to appreciable levels of this element within soils and waters. In the trivalent state, it poses little hazard to biological activity, but, unfortunately, in the hexavalent state it is very toxic to living matter. One must therefore assess the oxidation state of Cr in a given system and determine the potential for transformation between valence states. The objective of this paper to is review and provide new insight on reduction reactions of Cr(VI) within natural environments. A number of aerobic and anaerobic bacteria demonstrate the enzymatic ability to reduce Cr(VI) to Cr(III); two species can even grow using Cr(VI) as the terminal electron acceptor in respiration. The ability to reduce chromium in itself is not evidence that the process will take place at appreciable levels in natural environments, however. Reduced materials such as ferrous iron or hydrogen sulfide may compete with biological pathways in the reduction of Cr(VI). On the basis of measured reaction rates and derived rate expressions, we demonstrate that biological pathways are not likely to contribute to the reduction of chromate in anaerobic systems. Ferrous iron will dominate the reduction of chromate at pH values greater than ∼ 5.5, whereas hydrogen sulfide will dominate at pH values below this value. In contrast, bacteria may be the principal means by which Cr(VI) is converted to Cr(III) in aerobic environments. Thus, the process by which Cr(VI) is reduced will depend primarily on the aeration status of the system, and secondarily on pH and the concentrations of specific reduced phases.
Fabrication And Characterization Of PZT Thin Films For Micromotors (2005)

Piezoelectric membranes consisting of sputter and solgel deposited PbZr/sub x/T/sub 1-x/O/sub 3/ (PZT) films on silicon diaphragms have been fabricated, investigated, and applied for micromotors. The behavior of resonance frequencies was studied as a function of membrane thickness and dc- bias. Membranes of 4 mm diameter have been successfully applied as stator of a micro motor. The motor could be operated with voltages as low as 1.0 V/sub rms/. A 100 h degradation test of resonance frequency and amplitude has revealed a 5 % drop in amplitude, possibly due to depolarization.
Experience of handicap and anxiety in phobic postural vertigo (2004)

Patients with phobic postural vertigo scored higher than the control subjects with respect to all parameters with the exception of the physical subscale of the Dizziness Handicap Inventory. Because there were significantly more women in the control group we performed a gender-specific analysis of the results. The higher test scores among patients with phobic postural vertigo can be explained by the higher scores among women in this group, while the test results for men were more similar to those of the control group.
A qualitative comparison of MPEG view synthesis and light field rendering (2014)

Free Viewpoint Television (FTV) is a new modality in next generation television, which provides the viewer free navigation through the scene, using image-based view synthesis from a couple of camera view inputs. The recently developed MPEG reference software technology is, however, restricted to narrow baselines and linear camera arrangements. Its reference software currently implements stereo matching and interpolation techniques, designed mainly to support three camera inputs (middle-left and middleright stereo). Especially in view of future use case scenarios in multi-scopic 3D displays, where hundreds of output views are generated from a limited number (tens) of wide baseline input views, it becomes mandatory to fully exploit all input camera information to its maximal potential. We therefore revisit existing view interpolation techniques to support dozens of camera inputs for better view synthesis performance. In particular, we show that Light Fields yield average PSNR gains of approximately 5 dB over MPEG's existing depth-based multiview video technology, even in the presence of large baselines.
The floral transcriptome of ylang ylang (Cananga odorata var. fruticosa) uncovers biosynthetic pathways for volatile organic compounds and a multifunctional and novel sesquiterpene synthase (2015)

The pleasant fragrance of ylang ylang varieties (Cananga odorata) is mainly due to volatile organic compounds (VOCs) produced by the flowers. Floral scents are a key factor in plant-insect interactions and are vital for successful pollination. C. odorata var. fruticosa, or dwarf ylang ylang, is a variety of ylang ylang that is popularly grown in Southeast Asia as a small shrub with aromatic flowers. Here, we describe the combined use of bioinformatics and chemical analysis to discover genes for the VOC biosynthesis pathways and related genes. The scented flowers of C. odorata var. fruticosa were analysed by gas chromatography/mass spectrometry and a total of 49 VOCs were identified at four different stages of flower development. The bulk of these VOCs were terpenes, mainly sesquiterpenes. To identify the various terpene synthases (TPSs) involved in the production of these essential oils, we performed RNA sequencing on mature flowers. From the RNA sequencing data, four full-length TPSs were functionally characterized. In vitro assays showed that two of these TPSs were mono-TPSs. CoTPS1 synthesized four products corresponding to β-thujene, sabinene, β-pinene, and α-terpinene from geranyl pyrophosphate and CoTPS4 produced geraniol from geranyl pyrophosphate. The other two TPSs were identified as sesqui-TPSs. CoTPS3 catalysed the conversion of farnesyl pyrophosphate to α-bergamotene, whereas CoTPS2 was found to be a multifunctional and novel TPS that could catalyse the synthesis of three sesquiterpenes, β-ylangene, β-copaene, and β-cubebene. Additionally, the activities of the two sesqui-TPSs were confirmed in planta by transient expression of these TPS genes in Nicotiana benthamiana leaves by Agrobacterium-mediated infiltration.
VARIATION OF THE UV-TO-BLUE FLUORESCENCE RATIO FOR ORGANIC MATTER IN WATER UNDER CONDITIONS OF FLUORESCENCE SATURATION (2000)

Experimental results on non-linear fluorescence spectroscopy with laser excitation for organic matter in water are presented with emphasis on the variation of fluorescence spectral shapes through a wide range of the samples. Different types of organic material, such as algae cultures in water and aqueous solutions of commercially available DOM components (humic acid, fulvic acid, lignin, and mixtures of humic substances with phenolic compounds) were investigated. All substances under investigation show fluorescence satura-tion at both excitation wavelengths 266 and 355 nm used in the experiment. Excited at lexc = 266 nm, (la-ser pulse duration tp = 0.3 ns) Chlorella culture shows a different trend of the UV-to-blue fluorescence ratio compared to Chlorococcum culture and mixtures of humic substances and phenolic compounds with rising laser pulse power. Under certain conditions of excitation (lexc = 355 nm, tp = 0.3 ns) the fluores-cence spectra of humic acid in water manifest inhomogeneous broadening. A «red shift » of the maximum position with increasing excitation photon flux is described for the first time. For a lignin solution in water no change in spectral shape with alteration of laser power was observed. We resume that samples of natural organic matter of different origin can be distinguished applying non-linear fluorimetry, even in the case of similar steady-state fluorescence spectra. Non-linear fluorimetry gives us also the possibility to verify hy-potheses of the nature of fluorescence for complex organic substances.
Interaction Between 5-FluorouraciI, [6RS]Leucovorin, and Recombinant Human Interferon-α2a in Cultured Colon Adenocarcinoma Cells (1991)

Recombinant human interferon-alpha 2a (rIFN-alpha 2a; 500 or 5,000 IU/mL) or [6RS] leucovorin ([6RS]LV; 1 microM) each potentiated the cytotoxic activity of 5-fluorouracil (FUra) by 2.6- to 3.2-fold during 72 hr exposures in two human colon adenocarcinoma cell lines (GC3/c1; VRC5/c1). When all three agents were combined, FUra cytotoxicity was further potentiated by 3.2- to 4.3-fold (total 10- to 14-fold). Potentiation of FUra cytotoxicity occurred at clinically achieveable concentrations of rIFN-alpha 2a and [6RS]LV. Effects were reversed by dThd (20 microM), although the activity of CB3717, a quinazoline-based, specific inhibitor of thymidylate synthase, was not potentiated by rIFN-alpha 2a. Data suggest the requirement of a 5-fluoropyrimidine for biochemical modulation and interaction at the level of thymidylate synthase or DNA.