gebhart/patrepeval huggingface dataset:
Stabilization and Target Delivery of Nattokinase Using Compression Coating (2007)

The aim of the work is to develop a new formulation in order to stabilize a nutraceutical enzyme Nattokinase (NKCP) in powders and to control its release rate when it passes through the gastrointestinal tract of human. NKCP powders were first compacted into a tablet, which was then coated with a mixture of an enteric material Eudragit L100-55 (EL100-55) and Hydroxypropylcellulose (HPC) by direct compression. The activity of the enzyme was determined using amidolytic assay and its release rates in artificial gastric juice and an intestinal fluid were quantified using bicinchoninic acid assay. Results have shown that the activity of NKCP was pressure independent and the coated tablets protected NKCP from being denatured in the gastric juice, and realized its controlled release to the intestine based on in vitro experiments.
A cooling solution for power amplifier modules in cellular phone applications (2003)

Portable electronic products like cellular phones offer increasing features for enhanced communication. A number of digital and analog devices are used in such products. Multichip module (MCM) technologies allow unique opportunity for mixed signal computing and higher integration suitable for these products. Small form factor MCMs are currently being used in radio frequency (RF) MCM products for wireless applications. Depending on its size and functionality, each RF MCM product may have one to three CMOS, bipolar, and/or GaAs die, and 10 to 100 discretes interconnected on a laminate or ceramic substrate. We have studied the cooling path of a sample RF MCM structure that contains GaAs power amplifier (PA) die. The molded MCM package houses one GaAs, one CMOS, and >20 discretes on a 100 sq. mm four-layer laminate substrate. The MCM substrate has thermal vias and voltage planes for improved thermal performance. An improved cooling path is devised by implementing an extended heat removal path to transfer heat from the bottom surface of an MCM-to-board interface to the external antenna using a micro heat pipe. Modeling and experimental studies were conducted to demonstrate the effectiveness of using a micro-heat pipe structure in similar products. The analysis includes a highspeed transient thermal modeling, device sub modeling, and a system level modeling of the MCM in operation. The experimentally confirmed results show an almost 26% improvement in MCM package thermal performance by using a micro-heat pipe in the proposed implementation.
+24.6 dBm output power Er/Yb codoped optical amplifier pumped by diode-pumped Nd:YLF laser (1992)

An optical amplifier with an output power of +24.6 dBm has been demonstrated using an efficient Er/Yb codoped optical fibre and a diode-pumped Nd:YLF laser as the pump source.
Large Intelligent Surface Aided Multiuser MIMO: Passive Beamforming and Information Transfer (2020)

This paper investigates the passive beamforming and information transfer (PBIT) technique for the large intelligent surface (LIS) aided multiuser multiple-input multiple-output (MuMIMO) systems, where the LIS is deployed to enhance the primary communication via passive beamforming and simultaneously deliver its private data via spatial modulation. For the passive beamforming design, we propose to maximize the sum channel capacity of the LIS-aided Mu-MIMO systems and formulate the maximization problem as a two-step stochastic program. An efficient sample average approximation based iterative algorithm is developed for the passive beamforming design. For the receiver design, the signal detection at the receiver is a bilinear estimation problem since the LIS data are multiplicatively modulated onto the reflected signals of the reflecting elements. To solve this problem, we develop a turbo message passing algorithm in which the bilinear estimation problem is divided into two subproblems: one for the estimation of the user signals and the other for the estimation of the LIS data. Extensive simulation results are provided to demonstrate the advantages of our passive beamforming and receiver designs.
Time Domain Analysis for DP Simulations (2009)

As the offshore industry is developing into deeper and deeper waters Dynamic Positioning (DP) techniques are becoming more important to the industry. MARIN’s new multibody time domain simulation program aNySIM is recently extended with a module to simulate DP applications. The model is 6 degrees of freedom and includes a Kalman filter, PID controller and a Lagrange optimized allocation algorithm. Thruster interaction effects are taken into account in the model. The present paper focuses on the methods used in the numerical DP model. A typical case for a DP operated monohull drillship is presented and will be discussed in comparison with model test results.
Supercritical Hydrothermal Synthesis of Carboxylic Acid-surface-functionalized TiO2 Nanocrystals: pH Sensitive Dispersion and Hybridization with Organic Compounds (2010)

Abstract Surface-functionalized TiO2 (anatase) nanocrystals (NCs) (avg. d = 6.7 ± 1.6 nm) were synthesized by a supercritical hydrothermal method. A phosphonic acid derivative was used as surface modifier of TiO2 NCs. It was verified that the phosphonic acids were bound to the surface of TiO2 with very strong binding energy. The TiO2 NCs also exhibited extraordinarily high chemical stability. Such a strong binding between the phosphonic acid modifier and TiO2 had not been obtained by any other methods. The TiO2 NC showed sharp pH sensitive dispersion. Because of the functional as well as stable surface modifier layer, further manipulations on the surface using chemical reagents could be possible.
Copolymerization of 1,3‐butadiene and isoprene with cobalt dichloride/methylaluminoxane in the presence of triphenylphosphine (2002)

Abstract The homopolymerization and copolymerization of 1,3‐butadiene and isoprene were achieved at 0 °C with cobalt dichloride in combination with methylaluminoxane and triphenylphosphine (Ph 3 P). For 1,3‐butadiene, highly cis ‐specific and 1,2‐syndiospecific polymerization proceeded in the absence or presence of Ph 3 P, respectively, although the activity with Ph 3 P was much higher than that without Ph 3 P. Only a trace of the polymer was, however, obtained in isoprene polymerization when Ph 3 P had been added. For copolymerization, the polymer yield in the presence of Ph 3 P was about three times higher than that in its absence. Copolymerization in the presence of Ph 3 P was, therefore, investigated in more detail. Unimodal gel permeation chromatography elution curves with narrower polydispersity (weight‐average molecular weight/number‐average molecular weight ≈ 1.5) indicated that the propagation reaction proceeded by single‐site active species. Both the yield and molecular weight of the copolymer decreased with an increasing amount of isoprene in the feed, and this was followed by an increase in the isoprene content in the copolymer. The monomer reactivity ratios, r 1 (1,3‐butadiene) and r 2 (isoprene), were estimated to be 2.8 and 0.15, respectively. Although the 1,3‐butadiene content in the copolymer was strongly dependent on the comonomer composition in the feed, the ratio of 1,2‐inserted units to 1,4‐inserted units of 1,3‐butadiene was constant. Concerning the isoprene unit, the percentage of 1,2‐ and 3,4‐inserted units was increased at the expense of 1,4‐inserted units with an increasing isoprene content in the feed. © 2002 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 40: 3086–3092, 2002
Transmission power control techniques for the reverse link of OFDM-DS-CDMA system (2003)

A method of transmission power control (TPC) for orthogonal frequency division multiplexing direct sequence code division multiple access (OFDM-DS-CDMA), in order to compensate for power attenuation at each subcarrier, is proposed. Instead of assigning the same power levels for all-subcarriers, different transmission power levels are assigned to different subcarriers, according to the attenuation of the subcarriers. System performance, in terms of bit error rate (BER), has been evaluated by Monte Carlo simulation. The simulation results presented significant improvement; the proposed system performed much better than the system without TPC. It is shown that the each-carrier TPC performed better than all-carrier TPC, hence each-carrier TPC is more suitable for OFDM-DS-CDMA systems.
Local SAR reduction in parallel excitation based on channel‐dependent Tikhonov parameters (2010)

Significant SAR reductions can be obtained by optimizing channel-dependent Tikhonov parameters based on the relation between coil elements and SAR hot spot positions.
Propofol increases morbidity and mortality in a rat model of sepsis (2015)

This is the first study to assess prolonged effects of sepsis and long-term application of volatile sedatives compared to propofol on survival, cardiovascular, inflammatory and end organ parameters. Results indicate that volatile anesthetics dramatically improved survival and attenuate systemic inflammation as compared to propofol. The main mechanism responsible for adverse propofol effects could be an enhanced plasma endotoxin concentration, leading to profound hypotension, which was unresponsive to fluid resuscitation.
Secure programming cookbook for C and C (2003)

Secure Programming Cookbook for C and C++ is an important new resource for developers serious about writing secure code for Unix (including Linux) and Windows environments. This essential code companion covers a wide range of topics, including safe initialization, access control, input validation, symmetric and public key cryptography, cryptographic hashes and MACs, authentication and key exchange, PKI, random numbers, and anti-tampering.
Pushbutton Calling with a Two-Group Voice-Frequency Code (1960)

A customer voice-frequency pushbutton signaling scheme involving a new two-group signal code, termed “four-by-four”, is described. It is shown that the use of this code, with judiciously chosen frequencies, permits the detection of bona fide signals after transmission over any ordinary voice connection and facilitates discrimination against false signals resulting from speech. Apparatus for generating the tones is described, and the principles of reception are discussed.
Capturing and Representing Deliberation in Participatory Planning Practices (2010)

In this paper we argue for the importance of capturing and representing deliberation in participatory planning practices. We discuss the concept of deliberation in planning theory, and argue for a paradigm that puts deliberation at the centre of public participation to planning decision. We argue that in order to enable effective participation, the normally ephemeral delib- eration process needs to be captured and represented so that the information and knowledge gathered during deliberation is visible for all, can be effectively traced, reused, and can actively influence planning decisions. To scaffold this we describe the integration of three technologies to create a collective project memory structured against five dimensions of participatory plan- ning processes: dialogical, social, spatial, temporal and causal. Based on several authentic par- ticipatory planning cases, we report that this supported deliberation across planning tasks, communication modes, time and environments. The coupled use of online and offline group- ware technologies created a more expressive and transparent participatory knowledge base than is possible with conventional media, and enhanced participatory planning by: supporting the effective capture and representation of deliberation processes and products; providing a rich picture of the social setting in which planning decision develops and supporting reflection in and on planning actions.
Catalytic Asymmetric Umpolung Allylation of Imines (2016)

Here we report an iridium-catalyzed asymmetric umpolung allylation of imines as a general approach to prepare 1,4-disubstituted homoallylic amines, a fundamental class of compounds that are hitherto not straightforward to obtain. This transformation proceeds by a cascade involving an intermolecular regioselective allylation of 2-azaallyl anions and a following 2-aza-Cope rearrangement, utilizes easily available reagents and catalysts, tolerates a substantial scope of substrates, and readily leads to various enantioenriched, 1,4-disubstituted homoallylic primary amines.
Transition from Moderate to Excessive Drug Intake: Change in Hedonic Set Point (1998)

Differential access to cocaine self-administration produced two patterns of drug intake in rats. With 1 hour of access per session, drug intake remained low and stable. In contrast, with 6 hours of access, drug intake gradually escalated over days. After escalation, drug consumption was characterized by an increased early drug loading and an upward shift in the cocaine dose-response function, suggesting an increase in hedonic set point. After 1 month of abstinence, escalation of cocaine intake was reinstated to a higher level than before. These findings may provide an animal model for studying the development of excessive drug intake and the basis of addiction.
Three-dimensional echocardiographic reconstruction of the mitral valve, with implications for the diagnosis of mitral valve prolapse. (1989)

Mitral valve prolapse has been diagnosed by two-dimensional echocardiographic criteria with surprising frequency in the general population, even when preselected normal subjects are examined. In most of these individuals, however, prolapse appears in the apical four-chamber view and is absent in roughly orthogonal long-axis views. Previous studies of in vitro models with nonplanar rings have shown that systolic mitral annular nonplanarity can potentially produce this discrepancy. However, to prove directly that apparent leaflet displacement in a two-dimensional view does not constitute true displacement above the three-dimensional annulus requires reconstruction of the entire mitral valve, including leaflets and annulus. Such reconstruction would also be necessary to explore the complex geometry of the valve and to derive volumetric measures of superior leaflet displacement. A technique was therefore developed and validated in vitro for three-dimensional reconstruction of the entire mitral valve. In this technique, simultaneous real-time acquisition of images and their spatial locations permits reconstruction of a localized structure by minimizing the effects of patient motion and respiration. By applying this method to 15 normal subjects, a coherent mitral valve surface could be reconstructed from intersecting scans. The results confirm mitral annular nonplanarity in systole, with a maximum deviation of 1.4 +/- 0.3 cm from planarity. They directly show that leaflets can appear to ascend above the mitral annulus in the apical four-chamber view, as they did in at least one view in all subjects, without actual leaflet displacement above the entire mitral valve in three dimensions, thereby challenging the diagnosis of prolapse by isolated four-chamber view displacement in otherwise normal individuals. This technique allows us to address a uniquely three-dimensional problem with high resolution and provide new information previously unavailable from the two-dimensional images. This new appreciation should enhance our ability to ask appropriate clinical questions relating mitral valve shape and leaflet displacement to clinical and pathologic consequences.
Monoclonal antibody SN10 which shows a highly selective reactivity with human B leukemia-lymphoma and is effectively internalized into cells. (1991)

The monoclonal antibody termed SN10 (IgG1-k) which was generated and characterized in the present study shows a highly selective reactivity with fresh (uncultured) human leukemia-lymphoma cells. The antigen defined by SN10 is a cell surface glycoprotein composed of a single polypeptide chain of Mr 36,000 and designated as gp36. The primary reactivity of SN10 is against mature B-lineage leukemia-lymphoma cells. For instance, SN10 reacted with all of the 17 B non-Hodgkin's lymphoma specimens, all of the 15 B chronic lymphocytic leukemia specimens, both of the 2 B prolymphocytic leukemia specimens, all of the 3 B hairy cell leukemia specimens, and 2 of the 3 B acute lymphoblastic leukemia specimens tested. Of normal peripheral blood cells, only a marginal reactivity of SN10 was detected with a minor subpopulation (less than 1-4% among different specimens) of isolated B-cells from healthy donors. No significant reactivity of SN10 was detected against any other isolated normal peripheral blood cells which include T-cells, granulocytes, monocytes, erythrocytes, and platelets. Furthermore, no significant reactivity of SN10 was detected against normal bone marrow specimens. In immunohistological studies using frozen tissue sections, SN10 reacted well with malignant lymphomas and showed varying patterns of reaction with hyperplastic reactive lymph nodes. Various normal human tissues tested were unreactive with SN10. In general, glycoprotein 36 was more abundantly expressed on fresh (uncultured) leukemia-lymphoma cells than on cultured leukemia-lymphoma cell lines. No significant amount of circulating SN10 antigen was detected in the plasma of leukemia-lymphoma patients or normal healthy donors. Scatchard plot analysis of direct binding of radiolabeled SN10 to a fresh (uncultured) B non-Hodgkin's lymphoma cell specimen, a fresh B chronic lymphocytic leukemia cell specimen, and DND-39 (an American Burkitt's lymphoma cell line) showed equilibrium constants of 5.2, 5.8, and 6.8 x 10(8) liters/mol, respectively. Thus, SN10 shows a high binding avidity to each of the 3 B leukemia-lymphoma cell specimens tested. Ricin A chain conjugate of SN10 killed leukemia-lymphoma cells effectively, whereas the same conjugate showed no cytotoxicity against control cells. Thus, SN10 bound to target antigen on the cell surface was effectively internalized into the cell. The present results suggest the potential of SN10 for therapy as well as for diagnosis of various forms of leukemia-lymphoma, particularly mature B-lineage leukemia-lymphoma.
Molecular Distillation State of the Vitamins in Certain Fish Liver Oils (1937)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMolecular Distillation State of the Vitamins in Certain Fish Liver OilsK. C. D. HickmanCite this: Ind. Eng. Chem. 1937, 29, 10, 1107–1111Publication Date (Print):October 1, 1937Publication History Published online1 May 2002Published inissue 1 October 1937https://pubs.acs.org/doi/10.1021/ie50334a005https://doi.org/10.1021/ie50334a005research-articleACS PublicationsRequest reuse permissionsArticle Views160Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Effects of short term increase of intraocular pressure on optic disc cupping (1998)

<h3>AIMS</h3> To evaluate the effect of acute elevation of intraocular pressure (IOP) on optic disc cupping. <h3>METHODS</h3> 10 emmetropic and 10 myopic volunteers were included in this study. The cup area (CA) and cup volume (CV) of the optic disc were determined with the Heidelberg retina tomograph (HRT). After baseline determinations, a suction cup was used to increase the intraocular pressure (IOP) to 20–25 mm Hg above the baseline and HRT images were obtained. <h3>RESULTS</h3> Baseline IOP was 13.5 (SD 1.3) mm Hg and 12.6 (2.6) mm Hg in the emmetropic and myopic groups, respectively. The IOP was elevated to 35.4 (3.3) mm Hg and 34.4 (2.5) mm Hg in the emmetropic and myopic groups, respectively. When compared with their baseline values, the cupping variables (CA and CV) were significantly increased (p<0.05) during the suction treatment in both emmetropic and myopic subjects. <h3>CONCLUSION</h3> There was a significant enlargement in the optic disc cupping during the artificial increment of intraocular pressure in both emmetropic and myopic eyes. In non-glaucomatous eyes the optic nerve head has a partially dynamic topography dependent upon the level of IOP.
A phase II study of peptichemio in advanced breast cancer (1980)

A phase II trial of Peptichemio (PTC) was conducted on 56 patients with advanced breast cancer that had been resistant to treatment with cyclophosphamide. The overall response rate was 32%, with one complete remission, seven partial remissions, and ten instances of improved disease status. Soft tissue and bone lesions were the primary sites of response. The median duration of response was 11 weeks, with a range of 6--30 weeks. Major toxicities were myelosuppression, affecting predominantly the platelets, and sclerosing phlebitis. Myelosuppression was cumulative and thrombocytopenic bleeding was a likely contributing factor in the death of 2 patients. This trial showed that PTC is another alkylating agent with definite activity in the treatment of breast cancer. More importantly, it showed that cross-resistance with cyclophosphamide does not exist, at least in breast carcinoma.
Cytoplasmic Dynein LC8 Interacts with Lyssavirus Phosphoprotein (2000)

Using a yeast two-hybrid human brain cDNA library screen, the cytoplasmic dynein light chain (LC8), a 10-kDa protein, was found to interact strongly with the phosphoprotein (P) of two lyssaviruses: rabies virus (genotype 1) and Mokola virus (genotype 3). The high degree of sequence divergence between these P proteins (only 46% amino acid identity) favors the hypothesis that this interaction is a common property shared by all lyssaviruses. The P protein-dynein LC8 interaction was confirmed by colocalization with laser confocal microscopy in infected cells and by coimmunoprecipitation. The dynein-interacting P protein domain was mapped to the 186 amino acid residues of the N-terminal half of the protein. Dynein LC8 is a component of both cytoplasmic dynein and myosin V, which are involved in a wide range of intracellular motile events, such as microtubule minus-end directed organelle transport in axon "retrograde transport" and actin-based vesicle transport, respectively. Our results provide support for a model of viral nucleocapsid axoplasmic transport. Furthermore, the role of LC8 in cellular mechanisms other than transport, e.g., inhibition of neuronal nitric oxide synthase, suggests that the P protein interactions could be involved in physiopathological mechanisms of rabies virus-induced pathogenesis.