gebhart/patrepeval huggingface dataset:
1,2-Benzothiazines. II. The Preparation and Sodium Borohydride Reduction of 3-Acyl-2H-1,2-benzothiazin-4(3H)-one 1,1-Dioxides<sup>1</sup> (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT1,2-Benzothiazines. II. The Preparation and Sodium Borohydride Reduction of 3-Acyl-2H-1,2-benzothiazin-4(3H)-one 1,1-Dioxides1Harold Zinnes, Roger A. Comes, Francis R. Zuleski, Albert N. Caro, and John Shavel Jr.Cite this: J. Org. Chem. 1965, 30, 7, 2241–2246Publication Date (Print):July 1, 1965Publication History Published online1 May 2002Published inissue 1 July 1965https://pubs.acs.org/doi/10.1021/jo01018a029https://doi.org/10.1021/jo01018a029research-articleACS PublicationsRequest reuse permissionsArticle Views295Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Expression of β-subunit of HCG genes during normal and failed pregnancy (2005)

In cases of RM, low HCG could result from expression failure of HCGbeta genes, whereas in EP the problems other than the transcriptional failure contribute to reduced hormone levels. The expression patterns of CGB1 and CGB2 suggest their putative role in the implantation stage.
Sobre algunos Anobiidae (col.) de Turquía recogidos por el Dr. W. Wittmer (nota 78) (1977)

Par l'aimable entremise des Musées de Bâle et de Genève j'ai\n\t\t\t\t reçu les Anobiides recueillis par le Dr. W. WITTMER au cours de trois\n\t\t\t\t missions zoologiques (1967, 1969 et 1970) en Turquie.\n\t\t\t\t Cette intéressante collection renferme 19 formes appartenant\n\t\t\t\t aux genres Hedobia Latr., Ptinomorphus Muls. Rey, Dryophilus\n\t\t\t\t Chevr., Xestobium Motsch., Ochina Steph., Ernobius Thoms., Anobium\n\t\t\t\t F., Xyletinus Latr., Lasioderma Steph., Ptilinus Geoffr., Mesothes\n\t\t\t\t Muls. Rey et Stagetus Woll., dont un Ernobius (wittmeri n. sp.) est\n\t\t\t\t nouveau. Tous ces insectes font l'objet d'un bref commentaire se\n\t\t\t\t rapportant à leur morphologie, à leur éthologie et à leur distribution\n\t\t\t\t géographique.
Kinetics of the heterogeneous decomposition of nickel tetracarbonyl (1967)

Abstract The decomposition of nickel tetracarbonyl at pressures between 20 and 200 torrs was studied at temperatures from 100° to 225°C. In the cross‐flow system, the rate in the absence of appreciable dilution was primarily limited by kinetic resistances at temperatures up to about 175°C. over an effective Reynolds number range of 5 to 100. Gas phase diffusional resistances were controlling at higher temperatures. Corrections for natural convection were employed in both the kinetic and diffusional regions of control.
Influence of Induced Reactive Oxygen Species in p53-Mediated Cell Fate Decisions (2003)

The p53 tumor suppressor gene can induce either apoptosis or a permanent growth arrest (also termed senescence) phenotype in response to cellular stresses. We show that the increase in intracellular reactive oxygen species (ROS) associated with the magnitude of p53 protein expression correlated with the induction of either senescence or apoptosis in both normal and cancer cells. ROS inhibitors ameliorated both p53-dependent cell fates, implicating ROS accumulation as an effector in each case. The absence of Bax or PUMA strongly inhibited both p53-induced apoptosis and ROS increase, indicating an important role these p53 targets affecting mitochondrial function genes in p53-mediated ROS accumulation. Moreover, physiological p53 levels in combination with an exogenous ROS source were able to convert a p53 senescence response into apoptosis. All of these findings establish a critical role of ROS accumulation and mitochondrial function in p53-dependent cell fates and show that other ROS inducers can collaborate with p53 to influence these fate decisions. Thus, our studies imply that therapeutic agents that generate ROS are more likely to be toxic for normal cells than p53-negative tumor cells and provide a rationale for identifying therapeutic agents that do not complement p53 in ROS generation to ameliorate the cytotoxic side effects in normal cells.
AVO detectability against tuning and stretching artifacts (1998)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1998AVO detectability against tuning and stretching artifactsAuthors: Wenjie DongWenjie DongMobil E&P Technical Centerhttps://doi.org/10.1190/1.1820387 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1820387FiguresReferencesRelatedDetailsCited By4. Chapter 4: Development GeophysicsColin MacBeth, Sankar Muhuri, William L. Abriel, William Haworth, Mark Chapin, Peter Swinburn, Raphic van der Weiden, Dieter Skaloud, Sola Adesanya, David Stevens, Chris Varley, Jacob Wilkie, Eric Brentjens, Martijn Blaauw, Liz Ross, Kevin King, Gerard Bodewitz, Hajo van Hasselt, Greg Stone, Wim Twigt, Wim Swinkels, Andrew James, Tony Addis, Chris Parsons, Robert Meij, Sarah Bell, Alexei Trofimov, Patrick Jackson, Valery Cholovsky, Edwin Lamers, Syrie Crouch, Rusty (John) Gilbert, Yuhong Liu, William Abriel, Rachel Preece, Dongjun (Taller) Fu, E. Charlotte Sullivan, Kurt J. Marfurt, Jose Luis Masaferro, Ruth Bourne, Jean-Claude Jauffred, P. Avseth, T. Mukerji, A. Jørstad, G. Mavko, T. Veggeland, M. K. MacLeod, R. A. Hanson, C. R. Bell, S. McHugo, Jan H. Kommedal, Susan Fowler, John McGarrity, C. R. Bates, D. R. Phillips, R. Grimm, H. Lynn, B. Blonk, R. W. Calvert, J. K. Koster, and G. van der Zee21 March 2012Quantitative Seismic Interpretation27 January 2010 | , Vol. 80Tuning effect on fluid properties estimated from AVO inversionMaria Rojas and De‐hua Han7 December 2005Analysis and interpretation of seismic data from thin reservoirs: Northwest Java Basin, IndonesiaA. Adriansyah and George A. McMechan7 February 2012 | GEOPHYSICS, Vol. 67, No. 1Seismic reservoir mapping from 3‐D AVO in a North Sea turbidite systemP. Avseth, T. Mukerji, A. Jørstad, G. Mavko, and T. Veggeland7 February 2012 | GEOPHYSICS, Vol. 66, No. 4 SEG Technical Program Expanded Abstracts 1998ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1998 Pages: 2092 publication data© 1998 Copyright © 1998 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 06 Jan 2005 CITATION INFORMATION Wenjie Dong, (1998), "AVO detectability against tuning and stretching artifacts," SEG Technical Program Expanded Abstracts : 236-239. https://doi.org/10.1190/1.1820387 Plain-Language Summary PDF DownloadLoading ...
Preparation of cellulose graft copolymers having polypeptide side chains and their blood compatibility (1986)

Abstract Blood compatibility of cellulose graft copolymers with poly(γ‐benzyl‐ L ‐glutamate) and poly( N 5 ‐2‐hydroxyethyl‐ L ‐glutamine) (Cell‐ g ‐PBLG and Cell‐ g ‐PHEG) was examined in vivo blood tests. For this purpose, Cell‐ g ‐PBLG graft copolymers with PBLG contents ranging from 7 to 60 mol % were prepared by polymerizing N ‐carboxy‐γ‐benzyl‐L‐glutamate(γ‐BLG NCA) using aminoethyl cellulose (AE‐Cell) with degree of substitution of 0.05 as macroinitiator. Graft copolymerization was carried out under a variety of conditions at 20°C in dimethyl‐sulfoxide. Monomer conversion higher than 60% were obtained for all the polymerization runs. The solubility tests revealed that all of the AE‐Cell and the polypeptides formed were grafted. The Cell‐ g ‐PHEG graft copolymers were prepared by treating Cell‐ g ‐PBLG graft copolymers with 2‐amino‐1‐ethanol. Characterization of these graft copolymers were carried out by IR spectroscopy, DSC, and water content measurement. Tests for blood compatibility, in vivo , were made by a method of peripheral vein indwelling suture which was developed by one of the authors. The coating of graft copolymers on the polyester suture was made by casting either from formic acid solution of LiCl/dimethylacetamide solutions using water as the regenerating medium, and the polymer‐coated sutures were implanted into a jugular and femoral vein of a dog. The results showed that the graft copolymers examined have excellent antithrombogenic properties.
Desiccation and topping induced silencing of 'putrescine N-methyl transferase2' regulate nicotine biosynthesis in 'Nicotiana tabacum' cv. Petite Havana (2014)

The current study was an attempt to understand the regulation of nicotine biosynthesis due to desiccation and meristem topping in Nicotiana tabacum cv. Petite Havana. Our results showed that desiccation induced silencing of Putrescine N-Methyl Transferase 2 (PMT2) (EC 2.1.1.53), a rate limiting enzyme in the nicotine biosynthetic pathway, regulates nicotine levels in tobacco. A hairpin siRNA (hpsiRNA) was designed and expressed against pmt using a stress inducible promoter rd29A from Arabidopsis thaliana. Stable transgenic RNAi lines, developed by Agrobacterium mediated transformation, showed reduced accumulation of nicotine due to desiccation and topping. The increase in the nicotine level in wild type was 115% while in RNAi lines, RNAi1, RNAi2 and RNAi3 the increase was 19.9%, 30% and 21.62%, respectively, due to desiccation. Furthermore, meristem topping of desiccated plants increased nicotine accumulation by 38% in wild type and only 7–9% in RNAi lines. No secondary surge in any related secondary metabolite was detected. No detectable change in the phenotype was observed in RNAi lines. This study revealed the critical role of pmt in nicotine biosynthesis under desiccation and topping and the inducible regulation of endogenous genes for crop improvement.
Predictive value of clinic blood pressure variability for pressure changes during placebo in elderly hypertensives. (1997)

OBJECTIVES: Syst-China is the ongoing placebo-controlled double-blind outcome trial in older (aged 60 years or more) Chinese patients with isolated systolic hypertension (systolic blood pressure 160-219 mmHg and diastolic blood pressure < 95 mmHg). This article is based on the data accumulated until 31 August 1992. Its purpose is to investigate the extent to which the variability in the clinic blood pressure readings at baseline could predict the blood pressure changes observed in the placebo arm of the trial. METHODS: From 2379 patients recruited into the trial, 728 [455 men and 273 women, aged 66.7+/-5.5 years (mean +/- SD)] were selected, because their blood pressure readings for the three run-in visits as well as 3, 6 and 12 months after random allocation were available. Overall and between-visit blood pressure variabilities at baseline were estimated from the two readings obtained with the subject seated during the first and second run-in visits. The baseline blood pressure used to calculate the blood pressure changes during follow-up was the average of the two readings during the third run-in visit. RESULTS: The blood pressure variability at baseline was larger for women than it was for men. For all of the subjects combined, the blood pressure had decreased by 4.1+/-14.4 mmHg (P < 0.001) systolic and 0.5+/-6.7 mmHg (P < 0.06) diastolic by the 3-month follow-up visit, by 8.5+/- 15.2 and 1.4+/-7.5 mmHg, respectively, after 6 months and by 10.3+/-15.7 and 1.9+/-7.9 mmHg, respectively, after 1 year (p < 0.001 for all). Stepwise multiple regression analysis showed that sex, age, alcohol intake and the blood pressure at baseline were significant determinants of the long-term (1 year) blood pressure changes. Aftger adjustment for the aforementioned covariates, the between-visit variability was a significant predictor of the changes in the diastolic blood pressure after 1 year of placebo treatment for the men (partial r+/-SEM -0.36+/-0.12, P < 0.01) and for all of the subjects (-0.19+/-0.09, P < 0.05). For men, the partial regression coefficient between the overall variability and the changes in the diastolic blood pressure also attained statistical significance (-0.39+/- 0.14, P < 0.01). CONCLUSION: For older Chinese patients with isolated systolic hypertension, in particular for men, a higher blood pressure variability at baseline was associated with a larger decrease in diastolic blood pressure during 1-year follow-up on placebo, explaining up to 2% of the variance of the observed changes. Similar associations were not observed for systolic blood pressure.
Healthy Swing (2002)

A comprehensive, multidisciplinary model for the evaluation and rehabilitation of golf injuries has been developed, using a team of healthcare professionals and a golf teaching professional. This approach may play a role in facilitating recovery and sports participation in injured golfers.
Saline-Infusion Sonography Endometrial Sampling Compared With Endometrial Biopsy in Diagnosing Endometrial Pathology (2009)

II.
Virulence Gene Regulation by the <i>agr</i> System in <i>Clostridium perfringens</i> (2009)

A gram-positive anaerobic pathogen, Clostridium perfringens, causes clostridial myonecrosis or gas gangrene in humans by producing numerous extracellular toxins and enzymes that act in concert to degrade host tissue. The agr system is known to be important for the regulation of virulence genes in a quorum-sensing manner in Staphylococcus aureus. A homologue for S. aureus agrBD (agrBD(Sa)) was identified in the C. perfringens strain 13 genome, and the role of C. perfringens agrBD (agrBD(Cp)) was examined. The agrBD(Cp) knockout mutant did not express the theta-toxin gene, and transcription of the alpha- and kappa-toxin genes was also significantly decreased in the mutant strain. The mutant strain showed a recovery of toxin production after the addition of the culture supernatant of the wild-type strain, indicating that the agrBD(Cp) mutant lacks a signal molecule in the culture supernatant. An agr-virR double-knockout mutant was constructed to examine the role of the VirR/VirS two-component regulatory system, a key virulence regulator, in agrBD(Cp)-mediated regulation of toxin production. The double-mutant strain could not be stimulated for toxin production with the wild-type culture supernatant. These results indicate that the agrBD(Cp) system plays an important role in virulence regulation and also suggest that VirR/VirS is required for sensing of the extracellular signal and activation of toxin gene transcription in C. perfringens.
A dynamin GTPase mutation causes a rapid and reversible temperature-inducible locomotion defect in <i>C. elegans</i> (1997)

Drosophila shibire and its mammalian homologue dynamin regulate an early step in endocytosis. We identified a Caenorhabditis elegans dynamin gene, dyn-1, based upon hybridization to the Drosophila gene. The dyn-1 RNA transcripts are trans-spliced to the spliced leader 1 and undergo alternative splicing to code for either an 830- or 838-amino acid protein. These dyn-1 proteins are highly similar in amino acid sequence, structure, and size to the Drosophila and mammalian dynamins: they contain an N-terminal GTPase, a pleckstrin homology domain, and a C-terminal proline-rich domain. We isolated a recessive temperature-sensitive dyn-1 mutant containing an alteration within the GTPase domain that becomes uncoordinated when shifted to high temperature and that recovers when returned to lower temperatures, similar to D. shibire mutants. When maintained at higher temperatures, dyn-1 mutants become constipated, egg-laying defective, and produce progeny that die during embryogenesis. Using a dyn-1::lacZ gene fusion, a high level of dynamin expression was observed in motor neurons, intestine, and pharyngeal muscle. Our results suggest that dyn-1 function is required during development and for normal locomotion.
Halocyclization of Unsaturated Alcohols and Carboxylic Acids Using Bis(<i>sym</i>-collidine)iodine(I) Perchlorate (1988)

Reaction of I(collidine)+ 2 ClO- 4 with unsaturated alcohols and carboxylic acids in dichloromethane at ambient temperature has afforded three- to seven-membered-ring iodoethers and four- to seven-membered-ring iodolactones, respectively, in moderate yields and generally with high regioselectivity. The reaction is of particular utility for synthesis of 2-(1-iodoalkyl)oxiranes and -oxetanes.
The effect of low cost material Bagasse Fly ash to the removal of COD Contributing component of combined waste water of Sugar Industry. (2012)

To minimize the industrial pollution, advanced wastewater treatment techniques, such as adsorption, are economically and environmentally essential in the removal of organic and inorganic compounds from industrial wastewater. The present study focuses on the use of low cost adsorbent sugarcane bagasse fly ash to adsorb COD content of the combined wastewater of sugar industry. Bagasse Fly ash with specific surface area of 2637.784 cm2/gm is used as a clarifier to the combined waste water of Sugar mill at room temperature. The different dosage of bagasse fly ash is kept in contact for 24 hours and analyzed before and after treatment. The results of COD removal is up to 27.04% and is follow the Freundlich and Langmuir adsorption isotherm.
Synthesis and biodistribution of 99mTc-labeled piperidinyl bis(aminoethanethiol) complexes: potential brain perfusion imaging agents for single photon emission computed tomography (1988)

In developing clinically useful 99mTc-labeled radiopharmaceuticals for the evaluation of regional cerebral perfusion with single photon emission computed tomography (SPECT), a number of substituted alkyl(aryl)piperidinyl bis(aminoethanethiol) ligands for chelating [99mTc]TcO(III) were synthesized. Each ligand forms two diastereomers, syn and anti, after reacting with a racemic mixture of the ligand. The diastereomers were separated by high-pressure liquid chromatography. In biodistribution studies conducted in rats, the diastereomers exhibit widely disparate brain uptake values; however, this disparity seems to diminish as the steric bulk of the substituent at the C-4 position of the piperidinyl moiety increases. Furthermore, all the complexes evaluated failed to show a prolonged retention in the rat brain, suggesting that further structural modification may be necessary to obtain clinically useful complexes from this class of compounds.
Microvesicle-delivery miR-150 promotes tumorigenesis by up-regulating VEGF, and the neutralization of miR-150 attenuate tumor development (2013)

Tumor-associated macrophages (TAMs) mostly exhibit M2-like (alternatively activated) properties and play positive roles in angiogenesis and tumorigenesis. Vascular endothelial growth factor (VEGF) is a key angiogenic factor. During tumor development, TAMs secrete VEGF and other factors to promote angiogenesis; thus, anti-treatment against TAMs and VEGF can repress cancer development, which has been demonstrated in clinical trials and on an experimental level. In the present work, we show that miR-150 is an oncomir because of its promotional effect on VEGF. MiR-150 targets TAMs to up-regulate their secretion of VEGF in vitro. With the utilization of cell-derived vesicles, named microvesicles (MVs), we transferred antisense RNA targeted to miR-150 into mice and found that the neutralization of miR-150 down-regulates miR-150 and VEGF levels in vivo and attenuates angiogenesis. Therefore, we proposed the therapeutic potential of neutralizing miR-150 to treat cancer and demonstrated a novel, natural, microvesicle-based method for the transfer of nucleic acids.
Prognosis in amyotrophic lateral sclerosis (2003)

These findings are consistent with other population-based studies of ALS and confirm its pernicious nature. Older age, female sex, any bulbar features at onset, short time from symptom onset to diagnosis, lack of a marital partner, and disease severity are key prognostic factors. Serial measurement of severity would likely improve predictions.
Management of Graves Thyroidal and Extrathyroidal Disease: An Update (2020)

A clear trend towards serological diagnosis and medical treatment of GD has emerged.
Lanthanide ions as spectral converters for solar cells (2009)

The use of lanthanide ions to convert photons to different, more useful, wavelengths is well-known from a wide range of applications (e.g. fluorescent tubes, lasers, white light LEDs). Recently, a new potential application has emerged: the use of lanthanide ions for spectral conversion in solar cells. The main energy loss in the conversion of solar energy to electricity is related to the so-called spectral mismatch: low energy photons are not absorbed by a solar cell while high energy photons are not used efficiently. To reduce the spectral mismatch losses both upconversion and downconversion are viable options. In the case of upconversion two low energy infrared photons that cannot be absorbed by the solar cell, are added up to give one high energy photon that can be absorbed. In the case of downconversion one high energy photon is split into two lower energy photons that can both be absorbed by the solar cell. The rich and unique energy level structure arising from the 4f(n) inner shell configuration of the trivalent lanthanide ions gives a variety of options for efficient up- and downconversion. In this perspective an overview will be given of recent work on photon management for solar cells. Three topics can be distinguished: (1) modelling of the potential impact of spectral conversion on the efficiency of solar cells; (2) research on up- and downconversion materials based on lanthanides; and (3) proof-of-principle experiments. Finally, an outlook will be given, including issues that need to be resolved before wide scale application of up- and downconversion materials can be anticipated.
Association Between Licensure Examination Scores and Practice in Primary Care (2002)

Scores achieved on certification examinations and licensure examinations taken at the end of medical school show a sustained relationship, over 4 to 7 years, with indices of preventive care and acute and chronic disease management in primary care practice.