gebhart/patrepeval huggingface dataset:
Genetic analysis of insulin-like growth factor II and HLA-G in pre-eclampsia (2000)

Pre-eclampsia (PE) is uniquely a disease of pregnancy and is the major cause of foetal and maternal morbidity and mortality. Epidemiological studies show that PE is highly heritable, with a high incidence in all populations. The underlying pathology indicates that absent or shallow invasion of foetal trophoblasts into maternal arteries is a feature of true PE. The objective of this study was to determine the genetic factors influencing PE. A large number of mother-father-baby trios were collected in which the first pregnancy was complicated by severe PE. After careful examination of the epidemiology and pathology of the disease, two plausible candidate genes, namely insulin-like growth factor II (IGF-II) and HLA-G, were analysed for association with PE. No association was found between a commonly occurring polymorphism in IGF-II and PE. Three polymorphisms in HLA-G were analysed in the sample cohorts. No association was found between three polymorphisms in HLA-G and PE. However, the frequency of the HLA-G insertion/deletion polymorphism in exon 8 deviated significantly from Hardy-Weinberg expectations in PE off-spring, reflecting an excess of heterozygotes for these polymorphisms in PE offspring. The significance of this deviation is not clear and further genetic analysis will be necessary to confirm this finding and to explore further the candidacy of HLA-G in PE.
An Agent Based Encapsulator System: For Integrating and Composing Legacy System Functionalities (2015)

Nowadays, Service-Oriented Architectures (SOA) represents the means of Information Technologies (IT) which contribute to the agility of enterprise information systems (IS). Their principle main is to present the applications functionalities as services aligned with the company business. This presentation is promising in the sense that it tends to reduce the costs of integration, to give more importance to the reuse of information system functionalities in different business processes and, of course, to facilitate its adaptation to the unforeseen changes during the life cycle of information system. In this work, we present an approach based on multi-agent systems (MAS) for encapsulating and publishing Legacy system functionalities as web services in the goal to facilitate their integration on a SOA-based Information system. We have on a second part proposed a set of composition templates for composing legacy functionalities.
Systematic review of beating heart surgery with the Octopus® Tissue Stabilizer (2002)

The safety and efficacy of off-pump coronary artery bypass surgery with the aid of the Octopus Tissue Stabilizer (Octopus OPCAB), in comparison to conventional on-pump coronary artery bypass surgery (CPB-CABG), was examined by a systematic assessment of the peer-reviewed literature. The limited comparative data suggested that there was no difference in safety outcomes between Octopus OPCAB and CPB-CABG. The paucity of efficacy data reported in the higher level comparative studies meant that it was impossible to assess whether Octopus OPCAB was more efficacious than CPB-CABG. The evidence base for the procedure was deemed inadequate and an audit of the procedure was recommended.
Fiber optics improve downhole video (1992)

Fiber optics provided downhole videos with a tremendous bandwidth, permitting a rugged, small, 7/32-in. OD cable to be used in long lengths, even in wells with high surface pressure. The cameras have lens polishing compounds that prevent oil and condensate buildups even after lengthy encounters with these fluids. With these developments, real-time fiber optic downhole video systems are capable of providing excellent quality video pictures of deep well conditions. Deployed by wire line or coiled tubing, the downhole video provides for visually inspecting and recording conditions that have in the past largely been left to speculation. This paper reports that applications include: inspection perforations, casing, and tubing; viewing fluid injection, and oil and gas production; locating downhole fish. As the cliche goes: A picture is worth a thousand words. A real-time moving picture is worth even more.
Role of T and NK cells and IL7/IL7r interactions during neonatal maturation of lymph nodes (2006)

Lymph node (LN) development depends on prenatal interactions occurring between LN inducer and LN organizer cells. We have distinguished defects in LN formation due to failure in embryonic development (aly/aly) from defects in postnatal maturation (Il2rgamma(-/-)Rag2(-/-)). Both mutant strains form normal primordial LNs with differing fate. In aly/aly mice, the LN primordium dissipates irreversibly late in gestation; in contrast, Il2rgamma(-/-)Rag2(-/-) LN anlage persists for a week after birth but disperses subsequently, a process reversible by neonatal transfer of WT IL7r(+) TCR(+) T or natural killer (NK) cells, suggesting a role for IL7/IL7r interactions. Thus, we reveal a unique stage of postnatal LN development during which mature lymphocytes and IL7/IL7r interactions may play an important role.
Increasing Mitochondrial Substrate-level Phosphorylation Can Rescue Respiratory Growth of an ATP Synthase-deficient Yeast (2005)

In a previous study we have identified Fmc1p, a mitochondrial protein involved in the assembly/stability of the yeast F0F1-ATP synthase at elevated temperatures. The deltafmc1 mutant was shown to exhibit a severe phenotype of very slow growth on respiratory substrates at 37 degrees C. We have isolated ODC1 as a multicopy suppressor of the fmc1 deletion restoring a good respiratory growth. Odc1p expression level was estimated to be at least 10 times higher in mitochondria isolated from the deltafmc1/ODC1 transformant as compared with wild type mitochondria. Interestingly, ODC1 encodes an oxodicarboxylate carrier, which transports alpha-ketoglutarate and alpha-ketoadipate or any other transported tricarboxylic acid cycle intermediate in a counter-exchange through the inner mitochondrial membrane. We show that the suppression of the respiratory-growth-deficient fmc1 by the overexpressed Odc1p was not due to a restored stable ATP synthase. Instead, the rescuing mechanism involves an increase in the flux of tricarboxylic acid cycle intermediate from the cytosol into the mitochondria, leading to an increase in the alpha-ketoglutarate oxidative decarboxylation, resulting in an increase in mitochondrial substrate-level-dependent ATP synthesis. This mechanism of metabolic bypass of a defective ATP synthase unravels the physiological importance of intramitochondrial substrate-level phosphorylations. This unexpected result might be of interest for the development of therapeutic solutions in pathologies associated with defects in the oxidative phosphorylation system.
A Hybrid System for Cell Detection in Digital Micrographs (2004)

To analyze large sets of digital micrographs from high-throughput screening studies with constant accuracy, advanced image processing algorithms are necessary. In the literature, systems have been proposed applying modelbased fitting algorithms, morphological operators and artificial\nneural networks (ANN). Because single approaches show limited performance, we propose a hybrid system that combines the Hough transform with a multi-layer perceptron (MLP) network. Our results show, that the combination of both approaches improves the performance and the positions of cell bodies are obtained with increased sensitivity and positive predictive value.
Synthesis of photo‐scissible poly(<i>p</i>‐hydroxystyrene) derivatives by radical copolymerization of <i>p</i>‐hydroxystyrene derivatives and methyl vinyl ketone (2011)

A synthesis of a copolymer composed of p-hydroxystyrene (HSt) and methyl vinyl ketone (MVK) units was performed by radical copolymerization of O-protected HSt (protective group=tert-butyl, ethoxyethyl, and acetyl) with MVK followed by removal of the protective groups and photodegradable behavior of obtained copolymers. The molecular weights of these copolymers decreased under photoirradiation due to the Norrish-type II reaction of the ketone groups of MVK units. These results demonstrate that a copolymer composed of HSt and MVK units possesses good photo-scissibility.
Synthesis and Electronic Factors in Thermal Cyclodimerization of Functionalized Aromatic Trifluorovinyl Ethers (2006)

A series of 19 p-substituted aromatic trifluorovinyl ether compounds were prepared from versatile intermediate p-Br-C(6)H(4)-O-CF=CF(2) and underwent thermal radical mediated cyclodimerization to new difunctional compounds containing the 1,2-disubstituted perfluorocyclobutyl (PFCB) linkage. The synthetic scope demonstrates the functional group transformation tolerance of the fluorovinyl ether, and the dimers are useful as monomers for traditional step-growth polymerization methods. (19)F NMR spectra confirmed that p-substitution affects the trifluorovinyl ether group chemical shifts. The first kinetic studies and substituent effects on thermal cyclodimerization were performed, and the results indicated that electron-withdrawing groups slow the rate of cyclodimerization. The data were further analyzed using the Hammett equation, and reaction constants (rho) of -0.46 at 120 degrees C and -0.59 at 130 degrees C were calculated. This study presents the first liner free energy relationship reported for the cyclodimerization of aromatic trifluorovinyl ethers to PFCB compounds.
Laser ablation of dental calculus at 400 nm using a Ti:sapphire laser (2009)

A Nd:YAG laser-pumped, frequency-doubled Ti:sapphire laser is used for selective ablation of calculus. The laser provides ≤25 mJ at 400 nm (60-ns pulse width, 10-Hz repetition rate). The laser is coupled into an optical multimode fiber coiled around a 4-in.-diam drum to generate a top-hat output intensity profile. With coaxial water cooling, this is ideal for efficient, selective calculus removal. This is in stark contrast with tightly focused Gaussian beams that are energetically inefficient and lead to irreproducible results. Calculus is well ablated at high fluences ≥2J/cm2; stalling occurs below this fluence because of photobleaching. Healthy hard tissue is not removed at fluences ≤3 J/cm2.
Velocity map imaging study of OCS photodissociation followed by S(1S) autoionization at 157 nm (2005)

Atomic sulphur ions (S+) were observed directly by crossing a carbonyl sulphide (OCS) molecular beam with a F2 laser. In this study both S+ ion and electron images were measured using the velocity map imaging technique. The results imply that S+ is produced from the well-known photodissociation of OCS at 157 nm leading to the dominant S(1S) + CO(1Σ+) channel, and then the excited S(1S) atom is directly ionized by another 157 nm photon. Correlated vibrationally resolved angular distributions and internal energy distribution of the CO coproducts are reported here and compared with previous studies. This experiment yields strong and sharp S+ images which may be useful for calibrating any imaging or laser ionization apparatus when using a 157 nm laser. A number of technical aspects such as corrections for partial slicing and imperfect laser polarization are described. Abstraction of product angular distributions using both polarized and unpolarized photolysis lasers is also demonstrated using velocity map imaging.
A mutant of <i>Arabidopsis thaliana</i> displaying altered patterns of cellulose deposition (1995)

Summary A homozygous recessive mutant of Arabidopsis thaliana has been selected which displays altered patterns of cellulose deposition. The mutant was selected because leaf and stem trichomes lacked the strong birefringence under polarized light which is characteristic of plant cells which contain highly ordered cellulose in their secondary cell walls. Compared with wild‐type A. thaliana , this mutant (designated tbr for trichome birefringence) also displays reduced birefringence in the xylem of the leaf. Direct chemical analyses of root, stem, and leaf tissues, including isolated leaf trichomes, support the conclusion that tbr is impaired in its ability to deposit secondary wall cellulose in specific cell types, most notably in trichomes where the secondary wall appears to be totally absent. Altered patterns of wound‐induced callose deposition in trichomes and surrounding cells is another trait which also co‐segregates with the tbr mutation.
Une maladie sur cyprès due à une Coryneum (1963)

International audience
Plasticity of User Interfaces: Framework and Research Agenda. (1999)

This paper introduces the notion of plasticity, a new property of interactive systems that denotes a particular type of user interface adaptation. Plasticity is the capacity of a user interface to withstand variations of both the system physical characteristics and the environment while preserving usability. Typically, a ‘plastic’ electronic agenda would run both on a workstation and on a hand-held computer without requiring a complete system redesign and re-implementation. We present a generic framework inspired by the model-based approach, for supporting the development of plastic user interfaces. Within this framework, a plastic user interface is specified once and serves multiple sources of physical variations. The goal is to guarantee usability continuity under variations in physical constraints while minimizing development and maintenance costs. This framework is illustrated with two simple case studies. Preliminary results and the state of the art in HCI open a new research agenda for the design and development of plastic user interfaces.
Influence of the type of cellulosic derivatives on the texture, and oxidative and thermal stability of soybean oil oleogel (2016)

The use oleogels (defined as edible oils entrapped in a three-dimensional network employing a self-assembled structuring agent) has recently been proposed to replace saturated fat or trans-fats in foods. In this work the effects of different cellulose derivative mixtures (Avicel, ethyl cellulose and α-cellulose) on lipid stability, glass transition temperature and the texture of soybean oil oleogels were determined by employing a mixture design approach. Avicel affected lipid stability, increasing the oxidative rancidity and peroxide values of oleogels. Oleogels with higher proportions of Avicel also presented higher transition temperatures. A higher percent of ethyl cellulose and α-cellulose in the oleogel mixture resulted in a more stable system with lower oil rancidity and lower glass transition temperatures. In addition, Avicel resulted in a softer and less tacky texture, an important characteristic to consider for food applications.
A High Efficiency Protocol for Reporting Integrity Measurements (2008)

One of the important functionalities in trusted computing is platform attestation, which allows us to reporting the current configuration of the platform to a remote Challenger. As a result of single threaded access mode on Trusted platform module (TPM), the server platform needs to process integrity requests turn and turn about, and then an issue on response efficiency arises in practice. An improved attestation protocol based on batching has been proposed in this paper, which achieved integrity reporting by batching all requests that arrived within a short duration, and TPM need only one time signing operation.
Transformation of <i>Brassica napus</i> and <i>Brassica oleracea</i> Using <i>Agrobacterium tumefaciens</i> and the Expression of the <i>bar</i> and <i>neo</i> Genes in the Transgenic Plants (1989)

An efficient and largely genotype-independent transformation method for Brassica napus and Brassica oleracea was established based on neo or bar as selectable marker genes. Hypocotyl explants of Brassica napus and Brassica oleracea cultivars were infected with Agrobacterium strains containing chimeric neo and bar genes. The use of AgNO(3) was a prerequisite for efficient shoot regeneration under selective conditions. Vitrification was avoided by decreasing the water potential of the medium, by decreasing the relative humidity in the tissue culture vessel, and by lowering the cytokinin concentration. In this way, rooted transformed shoots were obtained with a 30% efficiency in 9 to 12 weeks. Southern blottings and genetic analysis of S1-progeny showed that the transformants contained on average between one and three copies of the chimeric genes. A wide range of expression levels of the chimeric genes was observed among independent transformants. Up to 25% of the transformants showed no detectable phosphinotricin acetyltransferase or neomycin phosphotransferase II enzyme activities although Southern blottings demonstrated that these plants were indeed transformed.
Synthesis, structure, and magnetic properties of ε-Co nanocrystalline thin films and annealing effects (2003)

Cobalt (Co) nanocrystalline thin films consisting of Co nanocrystals (NCs) embedded in an amorphous carbon matrix were directly synthesized at ambient temperature by codeposition of Co and carbon using high vacuum dual electron-beam evaporation. In the as-deposited films, Co was identified to have a cubic ε-Co structure (with a controllable particle size). After annealing at 360 °C for 2 h, the Co NCs with a particle size of 5 nm in the as-deposited film were transformed into hexagonal α-Co (8 nm in size), whereas, the as-deposited Co NCs of 3 nm in size had a tendency to coalesce and interconnect to each other, forming a face-centered-cubic β-Co network. While the ε-Co NCs of 3 nm in size showed superparamagnetism at room temperature, the ε-Co NCs of 5 nm in size exhibited a ferromagnetic state due to coupling interaction or local interparticle connections. The saturation magnetization and coercivity substantially increased after annealing compared to the as-deposited films due to coarsening of Co NCs.
Feature based CONDENSATION for mobile robot localization (2002)

Much attention has been given to CONDENSATION methods for mobile robot localization. This has resulted in somewhat of a breakthrough in representing uncertainty for mobile robots. In this paper we use CONDENSATION with planned sampling as a tool for doing feature based global localization in a large and semi-structured environment. This paper presents a comparison of four different feature types: sonar based triangulation points and point pairs, as well as lines and doors extracted using a laser scanner. We show experimental results that highlight the information content of the different features, and point to fruitful combinations. Accuracy, computation time and the ability to narrow down the search space are among the measures used to compare the features. From the comparison of the features, some general guidelines are drawn for determining good feature types.
Novel Binary Room-Temperature Complex System Based on LiTFSI and 2-Oxazolidinone and Its Characterization as Electrolyte (2007)

Binary room-temperature complex system has been prepared based on lithium bis(trifluoromethane sulfonyl) imide (LiN(SO2CF3)2, LiTFSI) and 2-oxazolidinone (C3H5NO2, OZO). Both LiTFSI and OZO are solid at room temperature, but their mixture is a liquid with a liquidus temperature about −58.4 °C at a molar ratio of 1:4.0 characterized by differential scanning calorimetry. Thermogravimetry analysis shows that the complex system possesses high thermal stability over a wide range of temperature. Infrared and Raman spectroscopic studies have been carried out to understand the interactions between the precursors, LiTFSI and OZO, of the complex system. It is shown that the OZO can coordinate with the Li+ cation and the TFSI- anion via their polar groups (the CO and NH groups). Such strong interactions lead to the dissociation of LiTFSI and the breakage of the hydrogen bonds among the OZO molecules, resulting in the formation of the complex. To have a comprehensive understanding to the above interactions, quantum chemistry calculations with nonlocal density function theory have also been performed on the free ions or organic molecule by determining their Mulliken charges, equilibrium configuration, binding energy, and the coordination number of Li+ ion. The calculations indicate that the ionic conductivity of the LiTFSI−OZO complex with different molar ratios depends strongly on the ionic species in the complex system. Electrochemical performances of the complex electrolyte are evaluated with ac impedance spectroscopy, cyclic voltammetry (CV), and in a test electric double layer capacitor, respectively. The complex at a molar ratio of 1:4.5 exhibits the highest ionic conductivity due to the relatively large amount of “free” ions at room temperature. The analysis for the CV behavior indicates that the electrochemical stability window of the electrolyte is about 3V. This kind of complex system proves to be a promising candidate of electrolytes for supercapacitor and other electrochemical devices.
Converged Media and Communication Services (2008)

Converged media and communication services (COMCO) is the conceptual approach of integrating telecommunication, Web 2.0 and Media/IPTV in one architectural approach. Current available service delivery platform (SDP) concepts are silo approaches, which belong more or less to one of the three groups: (mobile/fix) telecommunication SDP, IPTV SDP and pure Web SDP. The groups have in common the integration of OSS/BSS and identity management. A main concept of a SDP is beside the service delivery also easy service creation and thus reduced time-to-market. Such a concept of service creation is covered in the business process model and its view of service dependency and service definition. Service oriented architecture (SOA) is the conceptual framework within such a business process model, as it sees every service as loose coupled functional unit. The recombination of new services can be reduced to the recombination of existing services. So, it is reasonable to apply SOA concepts within a SDP, which also consist of a set of components as 1) telecommunication services (presence, messaging, VoIP call control), 2) Media/IPTV services (media control of VoD and Linear TV) and 3) Web 2.0 services (SOAP access to commercial deployed web services). When it comes to IMS, we speak about a NGN in terms of QoS and gateway to legacy networks (GSM, ISDN, POTS), but also about a SDP in terms of application server and AAA. Speaking strictly, we may use the application server in the context of SDP as abstraction layer towards the NGN. Such application servers poses a service enabler layer which is widely usable towards the trinity of telecommunication, Web 2.0 and IPTV combined in one single SDP concept. This paper addresses the orchestration of these application servers within a SOA inspired process model.
Relaxed DM Requirements During Class II Peptide Loading and CD4+ T Cell Maturation in BALB/c Mice (2001)

Current ideas about DM actions have been strongly influenced by studies of mutant strains expressing the H-2(b) haplotype. To evaluate DM contributions to class II activities in BALB/c mice, we generated a novel mutation at the DMa locus via embryonic stem cell technology. Unlike long-lived A(b)/class II-associated invariant chain-derived peptide (CLIP) complexes, mature A(d) and E(d) molecules are loosely occupied by class II-associated invariant chain-derived peptide and are SDS unstable. BALB/c DM mutants weakly express BP107 conformational epitopes and toxic shock syndrome toxin-1 superantigen-binding capabilities, consistent with partial occupancy by wild-type ligands. Near normal numbers of mature CD4(+) T cells fail to undergo superantigen-mediated negative selection, as judged by TCR Vbeta usage. Ag presentation assays reveal consistent differences for A(d)- and E(d)-restricted T cells. Indeed, the mutation leads to decreased peptide capture by A(d) molecules, and in striking contrast causes enhanced peptide loading by E(d) molecules. Thus, DM requirements differ for class II structural variants coexpressed under physiological conditions in the intact animal.