gebhart/patrepeval huggingface dataset:
<scp>XIV</scp>. Yeast sequencing reports. A 43·5 kb segment of yeast chromosome XIV, which contains <i>MFA2, MEP2, CAP/SRV2, NAM9, FKB1/FPR1/RBP1, MOM22</i> and <i>CPT1</i>, predicts an adenosine deaminase gene and 14 new open reading frames (1995)

A 43,481 bp fragment from the left arm of chromosome XIV of Saccharomyces cerevisiae was sequenced. A gene for tRNA(phe) and 23 non-overlapping open reading frames (ORFs) were identified, seven of which correspond to known yeast genes: MFA2, MEP2, CAP/SRV2, NAM9, FKB1/FPR1/RBP1, MOM22 and CPT1. One ORF may correspond to the yet unidentified yeast adenosine deaminase gene. Among the 15 other ORFs, four exhibit known signatures, which include a protein tyrosine phosphatase, a cytoskeleton-associated protein and two ATP-binding proteins, four have similarities with putative proteins of yeast or proteins from other organisms and seven exibit no significant similarity with amino acid sequences described in data banks. One ORF is identical to yeast expressed sequence tags (EST) and therefore corresponds to an expressed gene. Six ORFs present similarities to human dbESTs, thus identifying motifs conserved during evolution. Nine ORFs are putative transmembrane proteins. In addition, one overlapping and three antisense ORFs, which are not likely to be functional, were detected.
La integración agraria. (1979)

Hemodialysis could influence on visual parameters such as BCVA and refractive status by means of changes in blood glucose or possibly other systemic parameters.
Real-time PCR expression profile of all receptor and non-receptor tyrosine kinases in prostate cancer (2008)

<p>Objectives: Tyrosine kinases (TKs) represent a group of enzymes that play a key role in the development of cancer. They act as important relay points affecting proliferation, differentiation, cell motility and apoptosis. Consequently, they are the focus of studies investigating the molecular basis of tumour development and progress. For the first time, we show the gene expression signature of all TKs in prostate cancer. <br /> Methods: The expression of 89 TKs was examined in prostatic tissue by real-time PCR (i.e. TaqMan Low Density Array). Tissue sampling, RNA isolation and cDNA synthesis were meticulously standardized. Cancer specimens of defined histological grades were compared to benign tissue. Expression data was processed using a combination of different software solutions to take on the problems of normalization and statistics. <br /> Results: We identified six TK genes with a significant increase (ABL2: +3.46-fold) or decrease (FGFR2: -3.46-fold, FGFR4: -4.59-fold, NTRK1: -4.38-fold, NTRK3: -6.04-fold, ROR2: -3.765-fold; p=0,009-0,018) in gene expression. Commercially available antibodies for immunohistochemistry worked well for FGFR2 and ABL2 and confirmed our data on the protein level. <br /> Conclusions: Our results underline the potential of an all-TK expression array in cancer and point out a number of TKs that are markedly dysregulated. Especially the overexpression of ABL2 is a finding of high clinical interest, as it provides a rational molecular background for the successful application of imatinib mesylate in prostate cancer. </p>
Comparison among Reconstruction Algorithms for Quantitative Analysis of <sup>11</sup>C-Acetate Cardiac PET Imaging (2018)

All the tested reconstruction algorithms performed similarly for quantitative analysis of <sup>11</sup>C-acetate cardiac PET imaging. TOF and TPSF yielded highly consistent kinetic parameter results with superior image quality compared with FBP. OSEM was relatively less reliable. Both TOF and TPSF were recommended for cardiac <sup>11</sup>C-acetate kinetic analysis.
Dynamic Look-up Table Method for Optimizing the Training of Deep Neural Networks on Many-Core Architecture (2019)

Due to the excessive training parameters and computation of Deep Neural Network (DNN) models, we have witnessed the training time increases with the continued increase of the scale of DNN models. Convolution computation is the key step of feature extraction in DNN models and occupies about 90% of the computation operations in DNN models. It is therefore of great necessity to accelerate the speed of convolution calculation in order to improve the training efficiency of system. Currently, the traditional method is to transform convolution computation into matrix multiplication and execute on many-core architecture such as Graphic Processing Unit (GPU). However, due to matrix conversion and high computational complexity of matrix multiplication, these methods based on matrix multiplication such as Caffe, consume a lot of time in accessing memory and need to copy redundant data in process of matrix conversion. The low capacity of GPU memory further leads to the low training efficiency of DNN models. Therefore, we orchestrate a dynamic look-up table method instead of matrix multiplication to realize convolution calculation in order to optimize the training of DNN on many-core architecture. We further improve the parallelism of the look-up table method in a more fine-grained parallelism by paralleling the building convolution table and look-up table operation based on GPU. In our experiment, we tested and trained MINIST, CIFAR-10, CIFAR-100 and ImageNet data sets respectively. Experiments show that, compared to the original Caffe, the proposed dynamic look-up table method referred as LTP-Caffe can achieve up to 31% speed-up ratio in the training process of DNN models. Experiments further show that LTP-Caffe and Caffe are comparable in accuracy, but the iteration speed of LTP-Caffe is more quickly than the Caffe.
Optimal resist dispensing in step and flash NIL (2007)

Development of algorithm for drop dispensing optimization in ultraviolet nanoimprint lithography (UV-NIL) considering optimal filling of a stamp is reported.
Pressure dependence of optical transitions in semiconducting single‐walled carbon nanotubes (2004)

Abstract The effects of applied hydrostatic pressure on the optical transitions in semiconducting single‐walled carbon nanotubes with different diameters and chiralities have been studied using optical absorption and photoluminescence spectroscopy. The excitonic transitions associated with the band‐gap (the first van Hove transition) energies in the carbon nanotubes are found to shift to lower energy at a rate depending on nanotube structure. The excitonic transitions between the first excited confinement states (the second van Hove transitions) are found to be much less sensitive to the applied hydrostatic pressure. All nanotubes show a dependence on their chirality in terms of pressure coefficient of the band‐gap energy, with the larger‐diameter nanotubes exhibiting a higher sensitivity of the band‐gap energy to hydrostatic pressure. (© 2004 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Paper-Based Origami Triboelectric Nanogenerators and Self-Powered Pressure Sensors (2015)

Discovering renewable and sustainable power sources is indispensable for the development of green electronics and sensor networks. In this paper, we present origami triboelectric nanogenerators (TENGs) using paper as the starting material, with a high degree of flexibility, light weight, low cost, and recyclability. Slinky- and doodlebug-shaped TENGs can be easily fabricated by properly folding printer papers. The as-fabricated TENGs are capable of harvesting ambient mechanical energy from various kinds of human motions, such as stretching, lifting, and twisting. The generated electric outputs have been used to directly light-up commercial LEDs. In addition, the as-fabricated TENGs can also serve as self-powered pressure sensors.
Identification of a chromosomal gene controlling temperature-regulated expression of Shigella virulence. (1988)

Genes required for the full expression of Shigella virulence are on both the chromosome and a large virulence-associated plasmid. Expression of one or more virulence (vir) genes is temperature-regulated, wild-type strains being virulent (invasive) when grown at 37 degrees C but phenotypically avirulent (noninvasive) at 30 degrees C. A vir::lac operon fusion located on the virulence plasmid, which brings the lac genes under control of a temperature-regulated vir gene promoter, was used to select regulatory mutants constitutive for the Lac+ phenotype at the nonpermissive temperature. A transposon Tn10-induced mutant that was Lac+ at 30 degrees C and 37 degrees C was isolated, and the Tn10 insertion was transduced into a wild-type strain. The transductants all simultaneously became deregulated for virulence and invaded HeLa cells equally well at 30 degrees C and 37 degrees C. Other virulence-associated phenotypes were also deregulated and expressed at 30 degrees C. Southern hybridization with a probe for Tn10 determined the insertion to be on the chromosome. Fine mapping by transduction with phage P1L4 positioned the mutation between the galU and trp genes. A cosmid cloned fragment of Shigella chromosomal DNA containing the region around galU was used in complementation studies and showed that the closely linked regulatory gene was able to complement, in trans, the Tn10-induced mutation. We propose that this mutation defines a regulatory gene, virR, and that insertion of Tn10 into this gene inactivates a repressor that normally blocks expression of vir genes at 30 degrees C.
Fatty Acid Degradation in <i>Escherichia coli</i> (1971)

The properties of a transport system for the uptake of fatty acids into Escherichia coli cells are described. The system is induced under the same conditions as the enzymes involved in fatty acid degradation. In accordance with the chain‐length specificity of the acyl‐CoA synthetase, only fatty acids with more than eight carbon atoms are taken up. The reduced rate of uptake of fatty acids in mutants with various lesions in fatty acid degradation indicates that transport and metabolism are tightly coupled processes. The absence of an efflux reaction and the inability of a mutant lacking the acyl‐CoA synthetase to take up fatty acids support the hypothesis that this enzyme is involved in a vectorial acylation during the permeation process. Mutants lacking one or all of the enzymes enoyl‐CoA hydrase, β‐hydroxyacyl‐CoA dehydro‐genase and thiolase, when assayed with substrates having four carbon atoms, can partially degrade long‐chain length and medium‐chain length fatty acids. This suggests that there are at least two types of enzyme activity in the cell which differ in their specificities for acyl‐CoA substrates of various chain‐lengths. A new old locus situated between the genes proA and proB on the E. coli linkage group is described. Lesions in this gene make the cell unable to degrade fatty acids of any carbon number, and must therefore lack an element common to the degradation of all fatty acids. Fatty acids taken up by these mutants are exclusively incorporated into membrane phospholipids.
Iamin: A Human Growth Factor with Multiple Wound-Healing Properties (1987)

Wound-healing remains a major medical problem. Yearly in the United States alone there are 29 million in-patient hospital surgical procedures (plus many more handled on an out-patient basis), 2.3 million burns requiring medical attention, approximately 6 million bedsores (decubitus ulcers) at any given time, 1.1 million severe fractures, and 2 million chronic diabetic ulcers (leading to 40,000 leg amputations yearly) [1].
The 5'-Nucleotidase of Escherichia coli (1967)

Abstract An enzyme, 5'-nucleotidase, was purified from Escherichia coli. With the use of the osmotic shock technique, a 5000-fold purification was achieved with DEAE-cellulose chromatography, hydroxylapatite chromatography, and repeat DEAE-cellulose chromatography. This enzyme hydrolyzes 5'-AMP, ATP, uridine diphosphate glucose and bis(p-nitrophenyl)phosphate. The ratios of specific activities remain constant for the various substrates throughout the purification, and the heat inactivation curves parallel each other. The purified 5'-nucleotidase of E. coli hydrolyzed all 5'-ribo- and deoxyribonucleotides with optimal activity against 5'-AMP. Substitution by a phosphoryl group as in pXp makes a compound resistant, as does substitution by another nucleotide as in pXpY. The enzyme is inactive against all sugar phosphates but will hydrolyze UDP-glucose. The 5'-AMP activity has a pH optimum of 6.0, the ATP activity 6.8, and UDP-glucose activity 7.4. The 5'-AMP activity is stimulated 100-fold by 5 x 10-3 m Co++ and 200-fold by the further addition of Ca++. The enzyme is inhibited by 0.1 m Zn++ and chelating agents. Only Mn++ is effective in replacing the Co++ stimulation of 5'-AMP or ATP hydrolysis, but Co++ is not needed for the UDP-glucose hydrolysis. The enzyme is minimally affected by its ionic environment, but it is highly labile to denaturation in the absence of bovine serum albumin. Phosphate is not inhibitory. The enzyme has been shown to be pure, as judged by molecular sieve chromatography, polyacrylamide disk gel electrophoresis, and ultracentrifugation. An s20,w value of 4.2 has been obtained. A molecular weight of 52,000 was found. The amino acid composition showed no unusual distribution.
A Performance Simulation Tool for the Analysis of Data Gathering in Both Terrestrial and Underwater Sensor Networks (2017)

Wireless sensor networks (WSNs) have greatly contributed to human-associated technologies. The deployment of WSNs has transcended several paradigms. Two of the most significant features of WSNs are the intensity of deployment and the criticalness of the applications that they govern. The tradeoff between volume and cost requires justified investments for evaluating the multitudes of hardware and complementary software options. In underwater sensor networks (USNs), testing any technique is not only costly but also difficult in terms of full deployment. Therefore, evaluation prior to the actual procurement and setup of a WSN and USN is an extremely important step. The spectrum of performance analysis tools encompassing the test-bed, analysis, and simulation has been able to provide the prerequisites that these evaluations require. Simulations have proven to be an extensively used tool for analysis in the computer network field. A number of simulation tools have been developed for wired/wireless radio networks. However, each simulation tool has several restrictions when extended to the analysis of WSNs. These restrictions are largely attributed to the unique nature of each WSN within a designated area of research. In addition, these tools cannot be used for underwater environments with an acoustic communication medium, because there is a wide range of differences between radio and acoustic communications. The primary purpose of this paper is to present, propose, and develop a discrete event simulation designed specifically for mobile data gathering in WSNs. In addition, this simulator has the ability to simulate 2-D USNs. This simulator has been tailored to cater to both mobile and static data gathering techniques for both topologies, which are either dense or light. The results obtained using this simulator have shown an evolving efficient simulator for both WSNs and USNs. The developed simulator has been extensively tested in terms of its validity and scope of governance.
The Curcumin Analog EF24 Targets NF-κB and miRNA-21, and Has Potent Anticancer Activity In Vitro and In Vivo (2013)

EF24 is a curcumin analog that has improved anticancer activity over curcumin, but its therapeutic potential and mechanism of action is unknown, which is important to address as curcumin targets multiple signaling pathways. EF24 inhibits the NF-κB but not the JAK-STAT signaling pathway in DU145 human prostate cancer cells and B16 murine melanoma cells. EF24 induces apoptosis in these cells apparently by inhibiting miR-21 expression, and also enhances the expression of several miR-21 target genes, PTEN and PDCD4. EF24 treatment significantly suppressed the growth of DU145 prostate cancer xenografts in immunocompromised mice and resulted in tumor regression. EF24 enhanced the expression of the miR-21 target PTEN in DU145 tumor tissue, but suppressed the expression of markers of proliferating cells (cyclin D1 and Ki67). In syngeneic mice injected with B16 cells, EF24 treatment inhibited the formation of lung metastasis, prolonged animal survival, inhibited miR-21 expression and increased the expression of miR-21 target genes. Expression profiling of miRNAs regulated by EF24 in vitro and in vivo showed that the antitumor activity of EF24 reflected the enhanced expression of potential tumor suppressor miRNAs as well as the suppressed expression of oncogenic miRNAs, including miR-21. Taken together, our data suggest that EF24 is a potent anticancer agent and selectively targets NF-κB signaling and miRNA expression, indicating that EF24 has significant potential as a therapeutic agent in various cancers.
Preparation of Purified KHSO5·H2O and nBu4NHSO5 from Oxone by Simple and Efficient Methods (2002)

The chemistry of various salt forms of Oxone, an environmentally friendly oxidant, has been investigated. In addition to advances in the preparation of analytically pure KHSO5·H2O and nBu4NHSO5, a soluble form of this oxidant, we have also studied some of the known oxidative chemistry that utilizes Oxone as the oxidant. Our results indicate that utilizing purified reagents makes these reactions easier to workup and amenable to large scale synthesis because the amount of salt in the reaction has been greatly reduced. (© Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002)
Hydration of tetracalcium phosphate (1993)

Hydrating tetracalcium phosphate evolves measurable heat for only a few hours when reacted isothermally in aqueous solution at temperatures between 25 and 70°C. The hydration reaction is incomplete, and tetra calcium phosphate is the only crystalline solid detected by X-ray diffraction analysis. The apparent activation energy of tetracalcium phosphate hydration is 36 kJ/mol. An activation energy of this magnitude is indicative of an interfacially controlled reaction. As with many hydration reactions, which are initially interfacially controlled, a layer of hydration product accumulates on the hydrating surfaces, and subsequent hydration becomes diffusionally controlled. Consistent with such a mechanistic path, seeding with calcium hydroxide reduces both the maximum rate of heat evolution and the total heat of reaction , while seeding with hydroxyapatite increases the total heat evolved. Complete hydration may be achieved when a tetracalcium phosphate slurry is continuously agitated for an extended period. After storage for one year large Ca(OH) 2 crystals have precipitated and an equilibrium involving hydroxyapatite and Ca(OH) 2 has been achieved. Carbonate readily enters the hydroxyapatite lattice and carbonated hydroxyapatite is formed in a CO 2 atmosphere. Although its composition is uncertain, the carbonated hydroxyapatite formed has a Ca/PO 4 ratio of 2, and it is the only phase observed at the complete reaction of tetra calcium phosphate under CO 2 .
Purification and Characterization of Human Pancreatic Phospholipase A2 and Development of a Radioimmunoassay1 (1983)

Human pancreatic phospholipase A2 was purified to homogeneity from pancreatic juice and a reliable radioimmunoassay for the enzyme was developed. The molecular weight of the enzyme as estimated by sodium dodecyl sulfate polyacrylamide gel electrophoresis was 14,000. Phosphatidylcholine was hydrolyzed well in an alkaline pH range, and the optimum activity was obtained at pH 9. Calcium ion was indispensable for activity. The enzyme was stable to heat treatment at 60 degrees C for 5 min. The radioimmunoassay system was highly sensitive, reproducible and specific. The dilution curves for the sera of patients with acute pancreatitis were parallel to the standard curve. In healthy individuals, serum phospholipase A2 concentrations ranged from 2.0 to 7.9 ng/ml, the average being 5.1 ng/ml (S.D.: 1.7). In patients with acute pancreatitis, significant elevations of serum phospholipase A2 contents were observed, and the highest value found was 4,000 ng/ml.
US-guided fine needle biopsy of solid renal masses--comparison of histology and cytology. (1991)

We report on 134 fine needle biopsies in 127 patients with an ultrasound finding suggesting renal malignancy. Biopsy was performed guided by dynamic ultrasound using an 0.6 mm aspiration needle for cytology and an 0.8 mm Surecut needle for histology. The retrieval rate for cytology was 97.8% compared to 79.1% for histology. Sensitivity for cytology and histology was 89.4% and 70.6%, respectively. The specificity of cytology was 85.4% giving a predictive value of a positive result of 91.6%. Specificity and positive predictive value for histology were both 100%. We conclude that fine needle aspiration biopsy from renal masses in our hands carries too high a false positive rate to be clinically safe. We recommend that fine needle histological biopsy replaces the aspiration biopsy in case of renal masses.
Comprehensive ESD protection for flip-chip products in a dual gate oxide 65nm CMOS technology (2006)

In this paper we present a modular and flexible new active MOSFET ESD rail clamp network configuration for use in flip-chip products. A key challenge was to efficiently fit all required ESD elements for an OVDD segment wholly into the I/O cells of that segment, without need for power/ground or spacer cells.
Fluid-structure interaction in crash simulation (2000)

In the automotive industry crash simulation plays an important role in decreasing development costs and in improving cars. To increase the reliability of crash simulation the modelling of parts of vehicles, which has been neglected in the past, becomes more important. One of these parts is the fuel tank together with the fuel inside the tank. An important aspect of a fuel tank in crash simulation is its kinematic behaviour as a result of the interaction with the fuel. To obtain good results in the simulation it is necessary to take into consideration the fluid properties of the fuel. The ability of crash simulation software to model fluid-structure interaction including free surfaces has been limited until now. Therefore, it is helpful to obtain some insight into modelling capabilities and to compare them with other sophisticated simulation techniques. In this paper three modelling techniques for fluid-structure interaction of fluids with free surfaces are presented. These results are compared with an experiment. It is shown that the simplest modelling technique is precise enough for reliable crash simulations.
Collision risk modeling of air traffic (2003)

Air Traffic Management (ATM) involves interactions between multiple human operators, procedures and technical systems, all of which are highly distributed. This yields that providing safety is more than making sure that each of the ATM elements functions properly safe; it is the complex interaction between them that determines safety. The assessment of isolated indicators falls short in covering the complex interactions between procedures, human operators and technical systems in safety-critical non-nominal situations. To improve this situation, this paper develops an approach towards the modelling and assessment of risk of mid-air collision between aircraft.
Activation of photodynamic substances by high-energy ultrasound-a new therapeutic principle? (1994)

We are interested in the interaction of photodynamic substances and high-energy-ultrasound to evaluate the effectivity of this new therapeutic approach to tumor treatment. The activation of the photosensitizer was assessed by using uric acid as a dosimeter. It was demonstrated that photodynamic substances can be activated with continuous-wave-ultrasound at frequencies of 450 kHz and 1184 MHz