gebhart/patrepeval huggingface dataset:
Improving the Efficiency of IGBT Series-Resonant Inverters Using Pulse Density Modulation (2011)

This paper analyzes a high-power (50 kW) high-frequency (150 kHz) voltage-fed inverter with a series-resonant load circuit for industrial induction heating applications, which is characterized by a full bridge inverter made of insulated-gate bipolar transistor and a power control based on pulse density modulation (PDM). This power control strategy allows the inverter to work close to the resonance frequency for all output-power levels. In this situation, zero-voltage switching and zero-current switching conditions are performed, and the switching losses are minimized. An additional improvement of inverter efficiency is achieved by choosing appropriate values of the modulation index. Results are verified experimentally using a prototype for induction hardening applications. A comparative study between the PDM and the classical power control by frequency variation will be made.
Potentiation of Doxorubicin-Induced Apoptosis of Resistant Mouse Leukaemia Cells by Ivermectin (2000)

The apoptosis and cell cycle effect of doxorubicin were evaluated in the presence and absence of ivermectin in mouse doxorubicin-resistant P388 leukaemia cells.

Ivermectin (2 μM) increased the sensitivity to doxorubicin of multidrug resistant (MDR) mouse leukemic P388 cells and significantly enhanced the apoptosis and intracellular accumulation of doxorubicin in resistant cells, but had no effect on parent cells. Using the fluorescent potential probe, 3,3′-dihexyl-oxacarbocyanine, we found that ivermectin induced a plasma membrane potential increase in resistant cells. Ivermectin also enhanced doxorubicin-induced G2/M blockade of the cell cycle in resistant cells. It is possible that ivermectin could reverse resistance by direct interaction with the P-glycoprotein or other components of the altered MDR cell membrane.
Improved Cycle Life and Stability of Lithium Metal Anodes through Ultrathin Atomic Layer Deposition Surface Treatments (2015)

Improving the cycle life and failure resistance of lithium metal anodes is critical for next-generation rechargeable batteries. Here, we show that treating Li metal foil electrodes with ultrathin (∼2 nm) Al2O3 layers using atomic layer deposition (ALD) without air exposure can prevent dendrite formation upon cycling at a current density of 1 mA/cm2. This has the effect of doubling the lifetime of the anode before failure both under galvanostatic deep discharge conditions and cyclic plating/stripping of symmetric Li–Li cells. The ALD treated electrodes can be cycled for 1259 cycles before failure occurs, which is attributed to improved electrode morphology resulting from homogeneous Li ion flux across the electrode/electrolyte interface.
[Stimulation of epidermal DNA syntgesis through vitamin A acid]. (1968)

1.

Eine 1%ige Vitamin A-Saure-Aceton-Losung wurde taglich einmal auf die Ohren erwachsener Meerschweinchen getraufelt. Bis zum 21. Behandlungstage wurden die vorbehandelten Ohren mit 3H-Thymidin markiert und, nach Gewebsentnahme 40 min spater autoradiographiert.




2.

Bei einigen Tieren wurde unmittelbar vor Behandlungsbeginn die Hornschicht durch Klebestreifenabris entfernt.




3.

Nach Hornschichtabris sind innerhalb von 24 Std weite Bezirke der gesamten Epidermis 3H-markiert. Bei erhaltener Hornschicht zeigt sich diese hohe Markierungsrate am 3. Tag.




4.

Wahrend der folgenden Behandlungstage entwickelt sich eine machtige Acanthose mit Zunahme der planimetrisch erfasten Epidermisflachen bis auf das Vierfache des Ausgangswertes. Die Verhornung ist anfangs parakeratotisch, spater orthokeratotisch. DNS-synthetisierende Zellen finden sich dann ausschlieslich in basalen Zellagen.




5.

Die Ruckwirkung lysosomaler Enzymfreisetzung auf die DNS-Synthese und Verhornung wird diskutiert.
Excited State Properties of Allylamine-Capped Silicon Quantum Dots (2007)

Excited-state properties of allylamine-capped silicon quantum dots (SiQDs) from Si10 to Si59 are studied using a density-functional tight-binding method and compared with available experimental data. Signatures in vibrational and optical absorption spectra are revealed, which show the detailed effect of modification of the SiQDs with allylamine. It is verified that the modification could be expected to not only reduce the surface oxidation rate but also maintain an efficient electronic transition feature that facilitates blue emission. The optical properties show significant size dependence due to the quantum confinement effect. The increase in the number of allylamine molecules could only result in a slight red shift of emission spectra.
Analytical Design of Biquadratic Filter Sections for Parametric Filters (1992)

A number of closed form solutions for the design of biquadratic bandpass, low pass, and high pass analog or digital filters meeting prescribed specifications and having unity gain stopbands have been derived. Cascading one of these biquadratic sections per frequency band results in a multiband gain equalizer where the filter characteristics within each band can be easily modified in response to user initiated requests.
Reclamation of a Coachella Valley grape ranch by changes in levelling, irrigation, and water source (1970)

A poorly drained Coachella Valley vineyard that suffered the loss of half its vines from salt damage has been reclaimed in six years by re-levelling the ground, changing the irrigation practices, and switching from the use of the highly saline Colorado River water to the use of a high-quality well water.
Modulating the spontaneous polarization of a ferroelectric liquid crystal via the photoisomerization of a chiral thioindigo dopant: (<i>R,R</i>)-6,6′-bis(1-methylheptyloxy) thioindigo (1996)

Abstract Doping the novel chiral photochromic dye (R,R)-6,6′-bis(1-methylheptyloxy) thioindigo into the Sc liquid crystal host MX6120 at a concentration of 7.2 mol % gives rise to a ferroelectric S∗c phase with a reduced polarization (P 0) of +14.4 nCcm−2. Results of time-resolved experiments demonstrate that the dye undergoes trans→cis photoisomerization in the Sc phase, although the efficiency of photoisomerization is significantly lower than in the nematic and isotropic liquid phases. A reversible modulation of P s on the order of 10 per cent is observed for the doped S∗c phase upon photoisomerization of the dye from a thermally relaxed trans form (+6.2 nC cm−2) to a cis-enriched photostationary state (+5.6 nC cm−2) at T – Tc = −10°C. Control experiments using mixtures of the racemic and optically active dye in a S∗c host suggest that P s photomodulation does not arise from a photomechanical effect. Consideration of the Boulder model for the molecular origins of P s provides a rationale for the observed P s photomodulation based on changes in the conformational equilibria of the 1-methylheptyloxy side-chains in the Sc binding site going from the trans form to the cis form of the thioindigo dopant.
The opportunities for future virtual power plant in the power market, a view point (2009)

The share of distributed generator (DG) in the power system generation is increasingly grown up. Due to the effects of DG on technical operation of the network and also considering the rapid extension of power market in the world wide, it is necessary to contemplate both technical aspect of network operation and market transactions in DG operation. Through the concept of virtual power plant (VPP), an aggregation of distributed energy resources that communicate with decentralized energy management system, the technical aspect of operation will be covered and participation of DG in the power market will be facilitated. This paper is concentrated on market aspects of operation of DG. A general framework for future VPP is discussed which it can be included the various DG technologies in both medium and low voltage distribution networks. New market transactions at distribution level, distribution company (DisCo) market in which both energy and ancillary services can be traded, is discussed and participation of VPP in both DisCo and wholesale market is investigated. Moreover, the exchanging power between wholesale market and DisCo market is briefly discussed.
Cloning and Characterization of a Novel GRP78-binding Protein in the Rat Brain (2003)

The full-length cDNA clone of a novel GRP78-binding protein (GBP) was isolated from rat brain using PCR-selected cDNA subtraction. GBP was predominantly expressed in neuronal cells among various brain tissues. GBP mRNA was already detected in the E12 brain and then gradually increased to reach a peak within P0-2 weeks after birth. GBP expression in the brain decreased age-dependently to approximately 30% of the postnatal level at 12 months. GBP encoded 1021 amino acids and was predicted to have two transmembrane regions and glutamic acid- and proline-rich regions. Because the sequence of GBP offered few clues to the possible function, we performed a GST-tagged GBP pull-down assay in PC12 lysates and identified GRP78, one of the heat shock proteins, as a counterpart. Observation of COS7 cells expressing green fluorescent protein- or Myc-tagged GBP showed that GBP was localized in the endoplasmic reticulum-Golgi domain where BODIPY 558/568 (4,4-difluro-5-(2-thienyl)-4-bora-3alpha,4alpha-diaza-S-indacene)-labeled brefeldin A accumulated. To investigate a biological role for GBP, we established Neuro2a cells stably expressing Myc-tagged GBP. Overexpression of GBP did not affect cell growth or morphological features but attenuated the time-dependent decrease in cell viability caused by serum deprivation compared with control cells. After 48 h of serum starvation, Neuro2a cells overexpressing GBP were resistant to the cell death induced by serum withdrawal. These results suggest that GBP would have a relevant functional role in embryonic and postnatal development of the brain.
Expression of dominant negative c-jun inhibits ultraviolet B-induced squamous cell carcinoma number and size in an SKH-1 hairless mouse model. (2003)

UVB radiation is a complete carcinogen able to initiate, promote, and progress keratinocyte cells toward carcinogenesis. Exposure to UVB leads to the propagation of a number of signal transduction pathways resulting in increased DNA binding of transcription factors, including activator protein-1 (AP-1), and subsequent gene expression. To test the hypothesis that AP-1 activation plays a role in the promotion of UVB-induced skin tumors, a dominant negative c-jun (TAM67) mutant transgene was expressed in the epidermis of SKH-1 hairless mice and bred with mice expressing an AP-1 luciferase reporter gene. Single UVB exposure experiments showed a significant decrease in AP-1 activity, as measured by luciferase levels, in mice expressing TAM67 72 h postexposure. Transgenic and nontransgenic littermates were placed into a chronic UVB exposure experiment, three exposures per week for 25 weeks. Expression of TAM67 reduced the number of tumors per mouse by 58% and tumor sizes were 79% smaller than the tumors present in the nontransgenic study group. These tumors were histologically identified as squamous cell carcinomas. TAM67 had no effect on UVB-induced hyperplasia because comparable epidermal thickening was observed in both study groups over a 5-day period post-UVB exposure. Immunohistochemical analysis showed a reduction in the number of cyclin D(1)-expressing cells in squamous cell carcinoma samples removed from the TAM67 study group. These data show that TAM67 can inhibit UVB-induced squamous cell carcinoma formation, suggesting that AP-1 is a good candidate target for the development of new chemoprevention strategies to prevent sunlight-induced skin cancers.
An Open, Secure and Flexible Platform Based on Internet of Things and Cloud Computing for Ambient Aiding Living and Telemedicine (2011)

Currently Internet of Things (IoT) and multimedia technologies have entered the healthcare field through ambient aiding living and telemedicine. However there are still several obstacles blocking in the way, the toughest ones among which are IoT interoperability, system security, streaming Quality of Service (QoS) and dynamic increasing storage. The major contribution of this paper is proposing an open, secure and flexible platform based on IoT and Cloud computing, on which several mainstream short distant ambient communication protocols for medical purpose are discussed to address interoperability; Secure Sockets Layer (SSL), authentication and auditing are taken into consideration to solve the security issue; an adaptive streaming QoS model is utilized to improve streaming quality in dynamic environment; and an open Cloud computing infrastructure is adopted to support elastic Electronic Health Record (EHR) archiving in the backend. Finally an integrated reference implementation is introduced to demonstrate feasibility.
Viruses' Life History: Towards a Mechanistic Basis of a Trade-Off between Survival and Reproduction among Phages (2006)

Life history theory accounts for variations in many traits involved in the reproduction and survival of living organisms, by determining the constraints leading to trade-offs among these different traits. The main life history traits of phages-viruses that infect bacteria-are the multiplication rate in the host, the survivorship of virions in the external environment, and their mode of transmission. By comparing life history traits of 16 phages infecting the bacteria Escherichia coli, we show that their mortality rate is constant with time and positively [corrected] correlated to their multiplication rate in the bacterial host. Even though these viruses do not age, this result is in line with the trade-off between survival and reproduction previously observed in numerous aging organisms. Furthermore, a multiple regression shows that the combined effects of two physical parameters, namely, the capsid thickness and the density of the packaged genome, account for 82% of the variation in the mortality rate. The correlations between life history traits and physical characteristics of virions may provide a mechanistic explanation of this trade-off. The fact that this trade-off is present in this very simple biological situation suggests that it might be a fundamental property of evolving entities produced under constraints. Moreover, such a positive correlation between mortality and multiplication reveals an underexplored trade-off in host-parasite interactions.
Fundamental limitations in the performance of chirped grating lenses on planar optical waveguides (1985)

The fundamental limitations in the performance of chirped grating lenses on planar optical waveguides caused by diffraction and by fabrication tolerances have been analyzed based on the generalized coupled mode theory (GCMT). The two most crucial lens parameters that affect the performance have been identified as the minimum grating periodicity and the maximum coupling coefficient. They have a strong effect on both the higher orders of diffraction and the phase distortions that eventually reduce the efficiency, enlarge the spot size and restirct the angular field of view. Both etched and deposited linear and curved grating lenses have been fabricated and evaluated on single-mode glass waveguides. Their measured performance is in good agreement with the predictions of the GCMT. High throughput efficiency (in excess of 80 percent) combined with very large angle of view (larger than 0.1 rad), as well as the performance limitations caused by diffraction have been demonstrated experimentally.
IL-7 Promotes T <sub>H</sub> 1 Development and Serum IL-7 Predicts Clinical Response to Interferon-β in Multiple Sclerosis (2011)

The interleukin-7 receptor α chain (IL-7Rα) gene was identified as a top non-major histocompatibility complex-linked risk locus for multiple sclerosis (MS). Recently, we showed that a T helper 1 (T(H)1)-driven, but not a T(H)17-driven, form of MS exhibited a good clinical response to interferon-β (IFN-β) therapy. We now demonstrate that high serum levels of IL-7, particularly when paired with low levels of IL-17F, predict responsiveness to IFN-β and hence a T(H)1-driven subtype of MS. We also show that although IL-7 signaling is neither necessary nor sufficient for the induction or expansion of T(H)17 cells, IL-7 can greatly enhance both human and mouse T(H)1 cell differentiation. IL-7 alone is sufficient to induce human T(H)1 differentiation in the absence of IL-12 or other cytokines. Furthermore, targeting IL-7/IL-7Rα is beneficial in experimental autoimmune encephalomyelitis (EAE), a mouse model of MS. Mice treated with IL-7Rα-blocking antibodies before or after onset of paralysis exhibited reduced clinical signs of EAE, with reduction in peripheral naïve and activated T cells, whereas central memory T, regulatory T, B, and natural killer cell populations were largely spared. IL-7Rα antibody treatment markedly reduced lymphocyte infiltration into the central nervous system in mice with EAE. Thus, a serum profile of high IL-7 may signify a T(H)1-driven form of MS and may predict outcome in MS patients undergoing IFN-β therapy. Blockade of IL-7 and the IL-7Rα pathway may have therapeutic potential in MS and other autoimmune diseases.
Julien and Marguerite Ravalet (1950)

Julien and Marguerite Ravalet Get access Donald Mcdonald Donald Mcdonald Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume 195, Issue 1, 7 January 1950, Page 18, https://doi.org/10.1093/nq/195.1.18b Published: 07 January 1950
Distribution of TCM Syndromes of COPD Patients with Triad (2012)

Objective:To discuss the TCM distribution of sweating-back cool-easy cold triad of chronic obstructive pulmonary disease patients.Methods:With the survey to collect 281 patients in out-patient and hospitalization with chronic obstructive pulmonary disease,investigation of their gender,age,height,weight,habits and other characteristics of general information,symptoms and pulmonary function indexes were made to summarize and analyze the TCM distribution.Results:There are 146 patients with triad,accounting for 52% of the total number of investigations which include 82 men,accounted for 56.2%;64 women accounted for 43.8%);for age distribution,12 patients are under 45 years old,accounting for 8.2%,65 patients are aged 45 to 52,accounting for 35.6%,82 patients are over 65 years old,and accounted for 56.2%;for Chinese syndrome type distribution,the number of excess syndrome is 37(25.3%),the deficiency syndrome is of 79(54.1%),and excess and deficiency mixed type is 30(20.6%),of which there are 80 cases of lung deficiency,20 cases of lung yin deficiency,8 cases of spleen-deficiency,there are 33 cases of kidney Yang deficiency,in the classification of COPD,there are 32 patients in COPD level 1,58 patients in COPD level 2,patients with COPD level 3 are 39,17 cases are COPD level 4.Conclusion:For patients have sweating-back cool-easy cold triad with chronic obstructive pulmonary disease,there is no significant difference in genders;in all age groups,patients over 65 years were significantly more than patients of other ages,and with age increased,the deficiency incidence rate tends to increase,deficiency of lung,spleen and kidney is common,and the main is lung deficinecy.Therefore treatment of COPD patients with triad should be treated with reinforcing Qi and strengthening exterior defence and take care of lung,spleen and kidney throughout the treatment course.
Large complex data: divide and recombine (D&R) with RHIPE (2012)

D&R is a new statistical approach to the analysis of large complex data. The data are divided into subsets. Computationally, each subset is a small dataset. Analytic methods are applied to each of the subsets, and the outputs of each method are recombined to form a result for the entire data. Computations can be run in parallel with no communication among them, making them embarrassingly parallel, the simplest possible parallel processing. Using D&R, a data analyst can apply almost any statistical or visualization method to large complex data. Direct application of most analytic methods to the entire data is either infeasible, or impractical. D&R enables deep analysis: comprehensive analysis, including visualization of the detailed data, that minimizes the risk of losing important information. One of our D&R research thrusts uses statistics to develop “best” division and recombination procedures for analytic methods. Another is a D&R computational environment that has two widely used components, R and Hadoop, and our RHIPE merger of them. Hadoop is a distributed database and parallel compute engine that executes the embarrassingly parallel D&R computations across a cluster. RHIPE allows analysis wholly from within R, making programming with the data very efficient. Copyright © 2012 John Wiley & Sons, Ltd.
Inducible nitric oxide synthase expression in activated rat microglial cultures is downregulated by exogenous prostaglandin E2 and by cyclooxygenase inhibitors (1997)

Prostaglandins and nitric oxide (NO) are among the numerous substances released by activated microglial cells, the brain resident macrophages, and they mediate several important microglial functions. We have previously shown that cyclooxygenase-2 (COX-2) and inducible NO synthase (iNOS), the two key enzymes in prostaglandin and NO synthesis, respectively, are rapidly co-induced in rat neonatal microglial cultures activated by bacterial endotoxin (lipopolysaccharide [LPS]) and that COX-2 expression appears to be under the negative control of endogenous as well as exogenous NO. In this study we show that exogenous prostaglandin E2 (PGE2), which is known to increase cyclic adenosine monophosphate (cAMP) levels in microglial cells, downregulates LPS-induced iNOS expression in a dose-dependent manner. The involvement of cAMP in the PGE2-dependent inhibition of iNOS is supported by several pieces of evidence. First, iNOS expression was also inhibited by agents such as isoproterenol and forskolin, which cause an elevation of cAMP levels, and by dibutyryl cAMP (dbcAMP), a cAMP stable analogue. Second, the inhibitory effect of PGE2 was mimicked by 11-deoxy-16,16-dm PGE2, a selective agonist at the PGE2 receptor subtype EP2, coupled to the activation of adenylyl cyclase, but not by sulprostone, a potent agonist at receptor subtypes EP3 and EP1, associated with an inhibition of adenylyl cyclase activity and intracellular Ca2+ elevation, respectively. Third, the inhibitory effect of PGE2 on NO synthesis was blocked by SQ 22,536, a specific inhibitor of adenylyl cyclase. Interestingly, the abrogation of endogenous prostanoid production by several COX inhibitors caused a reduction of iNOS expression, suggesting a positive modulatory effect of endogenous prostanoids of iNOS expression, as opposed to the inhibitory effect of exogenous PGE2.
Serum fibrosis markers are associated with liver disease progression in non-responder patients with chronic hepatitis C (2010)

Pretreatment serum fibrosis marker levels are significantly increased in patients with CHC at risk of clinical and histological disease progression. If validated in additional cohorts, measurement of these markers could help identify patients with CHC who would benefit from more frequent and intensive monitoring.