gebhart/patrepeval huggingface dataset:
A Trusted Multi-Party Authentication Scheme Based on Proactive-ElGamal Threshold Secret Sharing System (2012)

In most existing authentication schemes users are authenticated by the server one by one which results in lower efficiency of authentication when the number of users is large. Aiming at the drawback, this paper propose an efficient trusted multi-party authentication scheme based on threshold secret sharing, the discrete logarithm problem and ElGamal cryptosystem. Using (t,n) threshold secret sharing idea, the paper propose a (t,n) threshold authentication scheme which can not only simultaneously authenticate t users satisfying some specific conditions, but also authenticate new users dynamically by distributing a new authentication key for the new user which was produced by t old users and the new user together. Finally, the security and efficiency of the proposed scheme are analyzed.
The Preparation and Attempted Polymerization of Some 3-(Substituted amino)-2-oxazolidinones<sup>1</sup> (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Preparation and Attempted Polymerization of Some 3-(Substituted amino)-2-oxazolidinones1F. R. Cervi, M. Hauser, G. S. Sprague, and H. J. TroffkinCite this: J. Org. Chem. 1966, 31, 2, 631–632Publication Date (Print):February 1, 1966Publication History Published online1 May 2002Published inissue 1 February 1966https://pubs.acs.org/doi/10.1021/jo01340a530https://doi.org/10.1021/jo01340a530research-articleACS PublicationsRequest reuse permissionsArticle Views119Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Amantadine is beneficial in restless legs syndrome (2000)

Twenty-one patients (mean age 70 yrs) with restless legs syndrome (RLS) were treated with amantadine in an open-label trial. Amantadine was started at 100 mg per day and was increased every 3-5 days by 100 mg (up to a maximum of 300 mg per day) until significant relief of symptoms or intolerable side effects were experienced. Patients were rated pre- and posttreatment using an RLS rating scale (0-10). Each patient also rated the degree of response in a continuous scale from 0% (no improvement) to 100% (complete improvement). Eleven of 21 (52%) had subjective benefit to amantadine, with degree of response ranging from 25%-100% (mean 69%) among responders. Six had 95%-100% improvement. The RLS score for all 21 patients dropped from a mean (+/- standard deviation) of 9.8 +/- 0.6 (range, 8-10) pretreatment to 6.6 +/- 3.8 (range, 0-10) posttreatment (p = 0.001). The duration of response was 0-13 months (mean, 3.6 +/- 4.5), with nine responders still remaining on the drug as of last follow up. The mean effective dose was 227 mg per day. The most common side effects were drowsiness (3), fatigue (2), and insomnia (2); only two stopped amantadine because of side effects. We conclude that amantadine is an effective and well-tolerated drug for RLS.
Post-Translational Incorporation of L-Phenylalanine into the C-Terminus of α-Tubulin as a Possible Cause of Neuronal Dysfunction (2016)

α-Tubulin C-terminus undergoes post-translational, cyclic tyrosination/detyrosination, and L-Phenylalanine (Phe) can be incorporated in place of tyrosine. Using cultured mouse brain-derived cells and an antibody specific to Phe-tubulin, we showed that: (i) Phe incorporation into tubulin is reversible; (ii) such incorporation is not due to de novo synthesis; (iii) the proportion of modified tubulin is significant; (iv) Phe incorporation reduces cell proliferation without affecting cell viability; (v) the rate of neurite retraction declines as level of C-terminal Phe incorporation increases; (vi) this inhibitory effect of Phe on neurite retraction is blocked by the co-presence of tyrosine; (vii) microtubule dynamics is reduced when Phe-tubulin level in cells is high as a result of exogenous Phe addition and returns to normal values when Phe is removed; moreover, microtubule dynamics is also reduced when Phe-tubulin is expressed (plasmid transfection). It is known that Phe levels are greatly elevated in blood of phenylketonuria (PKU) patients. The molecular mechanism underlying the brain dysfunction characteristic of PKU is unknown. Beyond the differences between human and mouse cells, it is conceivable the possibility that Phe incorporation into tubulin is the first event (or among the initial events) in the molecular pathways leading to brain dysfunctions that characterize PKU.
The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons (1995)

A search for POU domain sequences expressed in the human retina has led to the identification of three closely related genes: Brn-3a, Brn-3b, and Brn-3c. The structure and expression pattern of Brn-3b was reported earlier (Xiang et al., 1993); we report here the structures and expression patterns of Brn-3a and Brn-3c. Antibodies specific for each Brn-3 protein were generated and shown to label only ganglion cells in a variety of vertebrate retinas. A complex pattern of strongly and weakly immunolabeled ganglion cells was observed in mouse, cat, and monkey retinae. In mouse and cat retinae, Brn-3a and Brn-3b proteins are found in a large fraction of ganglion cells, whereas Brn-3c is present in fewer ganglion cells. In the cat retina, anti-Brn-3a immunoreactivity was strong in the small ganglion cells (gamma cells) and weak in the remaining ganglion cells (alpha and beta cells); anti-Brn-3b immunoreactivity was present in all ganglion cells; and anti-Brn3c immunoreactivity was confined to the small ganglion cells. Immunolabeling of macaque retinae following retrograde labeling from the lateral geniculate nucleus revealed strong anti-Brn-3a immunoreactivity in a minority of retrogradely labeled P-type ganglion cells, and weak Brn-3a immunoreactivity in all of the remaining P- and M-type ganglion cells. In the same retinae, strong anti-Brn-3b immunoreactivity was seen in nearly all P-type ganglion cells and weak immunoreactivity in nearly all M-type ganglion cells. Each of the Brn-3-specific antibodies also labeled subsets of neurons in the dorsal root and trigeminal ganglia, suggesting that primary somatosensory neurons and retinal ganglion cells share genetic regulatory hierarchies. In vitro selection of an optimal DNA binding site using the Brn-3b POU domain has revealed a consensus [(A/G)CTCATTAA(T/C)] that is recognized by each of the Brn-3 POU domains and is distinct from binding sites previously described for other POU domain proteins.
The Kinetics of the Reaction between the Ethylene Halohydrins and Hydroxyl Ion in Water and Mixed Solvents<sup>1a</sup> (1948)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Kinetics of the Reaction between the Ethylene Halohydrins and Hydroxyl Ion in Water and Mixed Solvents1aC. L. McCabe and J. C. WarnerCite this: J. Am. Chem. Soc. 1948, 70, 12, 4031–4034Publication Date (Print):December 1, 1948Publication History Published online1 May 2002Published inissue 1 December 1948https://pubs.acs.org/doi/10.1021/ja01192a018https://doi.org/10.1021/ja01192a018research-articleACS PublicationsRequest reuse permissionsArticle Views161Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Propagation testing multi-cell batteries. (2014)

Propagation of single point or single cell failures in multi-cell batteries is a significant concern as batteries increase in scale for a variety of civilian and military applications. This report describes the procedure for testing failure propagation along with some representative test results to highlight the potential outcomes for different battery types and designs.
Database synchronisation in military command and control systems (1992)

Database synchronisation is a vital aspect of any database system, be it commercial or military. It is especially important in military C/sup 3/I systems where critical decisions may be taken as a result of database information. Database synchronisation means that the data viewed by one user must be the same as that viewed by another user at a different physical location or node. This meas that the database system must maintain not only local integrity but also global consistency across all nodes. This is a complex task given the communications problems specific to military C/sup 3/I systems. Database synchronisation in military C/sup 3/I systems is a critical issue that is not fully addressed by the commercial database products currently available. With few exceptions, military customers need bespoke database software that can be specifically tailored to their precise requirements.<
 >
The STAR railgun concept (1999)

A novel concept for a staged augmented railgun is evaluated in which an external augmenting field would be applied to the bore of the railgun in addition to the self-induced magnetic field resulting from the current flow in the main rails. The augmenting magnetic field would be provided by multiple saddle-shaped coils located on the exterior of the gun barrel. These magnet coils, which would operate at high magnetic field strengths, would be transiently powered so that their magnetic field would only be present in the vicinity of the projectile. The energy contained in the coils would be transferred forward to successive coils as the projectile travels down the barrel. In principle, energy losses could therefore be minimized compared with other barrel concepts. However, a more detailed evaluation of this concept shows that very high voltages could be needed to power the coil, so that the concept may be unattractive for short barrels and high velocity applications.
Insulin Attenuation of Vasoconstrictor Responses to Phenylephrine in Zucker Lean ana Obese Rats (1991)

Recent data from this laboratory indicate that insulin resistant obese Zucker rats exhibit hypertension associated with exaggerated in vitro vascular reactivity to phenylephrine, serotonin, and KCl, and we have found insulin to attenuate vascular reactivity responses to these agonists. Accordingly, in the present study we evaluated the possibility that exaggerated vascular reactivity responses in obese Zucker rats may result from insulin resistance and a consequent failure of insulin to attenuate vasoactive responses. Thoracic aortae were isolated from male 16 week old lean and obese Zucker rats, and replicate helical strips from each animal were suspended in a muscle bath under a resting tension of 1.4 g in the presence or absence of insulin (0.1 mU/mL) for 1 h. The insulin was then washed out, and vascular reactivity responses to phenylephrine were determined. The obese rats exhibited greater reactivity to phenylephrine (ED50:1.10 +/- 90 X 10(-8) v 7.57 +/- 0.88 X 10(-10) mol/L in lean and obese rats, respectively, P less than .025). Insulin caused a significant attenuation of the contractile response in both the lean and obese aortae. However, lean rats exhibited a markedly greater attenuation than the obese rats (46.0 +/- 17.0 v 17.8 +/- 7.5% attenuation in the lean and obese rats, respectively, P less than .01). These data suggest that increased vascular reactivity responses in obese Zucker rats may result from their insulin resistant state and, consequently, a diminished ability of insulin to attenuate vasoconstrictor responses.
Real‐time MR fluoroscopic data acquisition and image reconstruction (1989)

We describe an experimental system for performing high-speed reconstruction of MR image data acquired with a GRASS sequence. System characteristics are an image acquisition time of 627 ms, continuous image reconstruction at a rate of 6 images/s, and an image reconstruction time of 120 ms. The results is a system for performing MR imaging in real time.
Casing Heading in Flowing Oil Wells (1987)

Summary Casing heading, an unsteady flow in oil wells completed without packers, occurs when both gas and liquid superficial velocities are low. A hydrodynamic model is presented that simulates laboratory data for the cases considered. Results confirm that heading occurs for low superficial gas and liquid velocities and that choking re-establishes stability.
Tracking Groups of Pedestrians in Video Sequences (2003)

This paper describes an algorithm for tracking groups of objects in video sequences. The main difficulties addressed in this work concern total occlusions of the objects to be tracked as well as group merging and splitting. A two layer solution is proposed to overcome these difficulties. The first layer produces a set of spatio temporal strokes based on low level operations which manage to track the active regions most of the time. The second layer performs a consistent labeling of the detected segments using a statistical model based on Bayesian networks. The Bayesian network is recursively computed during the tracking operation and allows the update of the tracker results everytime new information is available. Experimental tests are included to show the performance of the algorithm in ambiguous situations.
An Investigation of the Sound Absorption Properties of Flax/Epoxy Composites Compared with Glass/Epoxy Composites (2016)

Natural fiber based composites are becoming attractive candidates for use in various applications owing to their mechanical and sound absorption properties. It has been proposed that they could potentially replace glass fiber composites owing to their minimized impact on human health and the environment. Though studies have been dedicated to understanding their mechanical properties, few focus on quantifying their sound attenuation behavior. We investigated the sound absorption properties of flax/epoxy composites and found them to be superior to those of glass/epoxy composites. A noteworthy result was that the noise reduction coefficient increased from an average value of 0.095–0.11 for unidirectional flax/epoxy composite and to 0.10 for cross-ply flax/epoxy system. Results suggest that flax/epoxy composites could be less expensive, viable and ecologically superior substitutes for glass-fiber based composites, particularly in applications where sound absorption is important.
Progesterone action in the myometrium and decidua in preterm birth. (2012)

Progesterone is central to many reproductive processes and is critical in regulating the menstrual cycle and maintaining pregnancy. We discuss here similarities in the molecular mechanisms that regulate the process of decidualisation in endometrial stromal cells and uterine quiescence in myometrial smooth muscle cells. We discuss recent evidence that the decidua may be an important mediator of progesterone actions in the onset of labor in mammalian species lacking progesterone withdrawal. These observations have relevance to recent clinical observations of the effect of progesterone administration in the prevention of preterm labor. We suggest that further research is required to understand the role of progesterone in maintaining the decidua in late pregnancy and particular focus should be given to the mechanisms that increase prostaglandin production in the uterus at term.
Fragment‐based modeling of NAD binding to the catalytic subunits of diphtheria and pertussis toxins (1998)

We describe a novel application of a fragment-based ligand docking technique; similar methods are commonly applied to the de novo design of ligands for target protein binding sites. We have used several new flexible docking and superposition tools, as well as a more conventional rigid-body (fragment) docking method, to examine NAD binding to the catalytic subunits of diphtheria (DT) and pertussis (PT) toxins, and to propose a model of the NAD–PT complex. Docking simulations with the rigid NAD fragments adenine and nicotinamide revealed that the low-energy dockings clustered in three distinct sites on the two proteins. Two of the sites were common to both fragments and were related to the structure of NAD bound to DT in an obvious way; however, the adenine subsite of PT was shifted relative to that of DT. We chose adenine/nicotinamide pairs of PT dockings from these clusters and flexibly superimposed NAD onto these pairs. A Monte Carlo–based flexible docking procedure and energy minimization were used to refine the modeled NAD–PT complexes. The modeled complex accounts for the sequence and structural similarities between PT and DT and is consistent with many results that suggest the catalytic importance of certain residues. A possible functional role for the structural difference between the two complexes is discussed. Proteins 31:282–298, 1998. © 1998 Wiley-Liss, Inc.
Phase II Evaluation of Temozolomide and 13-cis-Retinoic Acid for the Treatment of Recurrent and Progressive Malignant Glioma: A North American Brain Tumor Consortium Study (2003)

TMZ and cRA were active, exceeding our 20% thresholds for PFS 6 success, assuming 20% improvement over our previously reported database (glioblastoma multiforme: expected, 30%; observed, 32%; anaplastic glioma: expected, 40%; observed, 50%).
The simian virus 40 minor structural protein Vp3, but not Vp2, is essential for infectious virion formation (2003)

The SV40 capsid is composed of pentameric capsomeres of the major structural protein Vp1. The two minor structural proteins, Vp2 and Vp3, interact with the capsid. Here, the roles of Vp2 and Vp3 were explored during the course of SV40 infection. Start codons of Vp2, Vp3, or both Vp2 and Vp3, were destroyed by site-directed mutagenesis, and mutant genomes were transfected into CV-1 cells. SV40DeltaVp2 produced plaques and infectious virion particles with titres indistinguishable from wild-type. SV40DeltaVp3 and SV40 DeltaVp2/Vp3 were defective in plaque formation and rendered no infectious particles. All three mutants showed normal nuclear localization of T-Ag and Vp1; they also showed packaging of SV40 DNA by nuclease digestion assays. Thus, Vp3 is essential for formation of infectious SV40 particles, whereas Vp2 is not. One critical role of full-length Vp3 appears to be in virus-cell interactions at post-packaging steps of a permissive infection.
Alteration of Chain Length Substrate Specificity of <i>Aeromonas caviae R</i> -Enantiomer-Specific Enoyl-Coenzyme A Hydratase through Site-Directed Mutagenesis (2003)

Aeromonas caviae R-specific enoyl-coenzyme A (enoyl-CoA) hydratase (PhaJ(Ac)) is capable of providing (R)-3-hydroxyacyl-CoA with a chain length of four to six carbon atoms from the fatty acid beta-oxidation pathway for polyhydroxyalkanoate (PHA) synthesis. In this study, amino acid substitutions were introduced into PhaJ(Ac) by site-directed mutagenesis to investigate the feasibility of altering the specificity for the acyl chain length of the substrate. A crystallographic structure analysis of PhaJ(Ac) revealed that Ser-62, Leu-65, and Val-130 define the width and depth of the acyl-chain-binding pocket. Accordingly, we targeted these three residues for amino acid substitution. Nine single-mutation enzymes and two double-mutation enzymes were generated, and their hydratase activities were assayed in vitro by using trans-2-octenoyl-CoA (C(8)) as a substrate. Three of these mutant enzymes, L65A, L65G, and V130G, exhibited significantly high activities toward octenoyl-CoA than the wild-type enzyme exhibited. PHA formation from dodecanoate (C(12)) was examined by using the mutated PhaJ(Ac) as a monomer supplier in recombinant Escherichia coli LS5218 harboring a PHA synthase gene from Pseudomonas sp. strain 61-3 (phaC1(Ps)). When L65A, L65G, or V130G was used individually, increased molar fractions of 3-hydroxyoctanoate (C(8)) and 3-hydroxydecanoate (C(10)) units were incorporated into PHA. These results revealed that Leu-65 and Val-130 affect the acyl chain length substrate specificity. Furthermore, comparative kinetic analyses of the wild-type enzyme and the L65A and V130G mutants were performed, and the mechanisms underlying changes in substrate specificity are discussed.
BIOPHYSICAL CHARACTERISTICS OF ANTI-GALα1-3GAL IgM BINDING TO CELL SURFACES: IMPLICATIONS FOR XENOTRANSPLANTATION1 (2001)

The initial rate of binding of anti-Galalpha1-3Gal antibodies to endothelial cells was found to depend on antibody concentration, antibody diffusion, and antigen concentration. The presence of an intact glycocalyx had a greater impact on antibody binding than mobility of antigen in cell membranes. Disruption of glycocalyx increased the amount of antibody bound at equilibrium by more than 50%. Although the binding of anti-Galalpha1-3Gal antibodies to cell surfaces could be inhibited by soluble Galalpha1-3Gal, once bound, some anti-Galalpha1-3Gal could not be dissociated by competitive inhibitors of binding or by denaturation of the bound Ig with chaotropic reagents, but could be dissociated by reduction of disulfide bonds, suggesting that attachment to cell surfaces was, at least in part, by means other than specific reaction with the epitope.
Five-Level Current-Source Inverters With Buck–Boost and Inductive-Current Balancing Capabilities (2009)

This paper presents new five-level current-source inverters (CSIs) with voltage/current buck-boost capability, unlike existing five-level CSIs where only voltage-boost operation is supported. The proposed inverters attain self-inductive-current-balancing per switching cycle at their dc front ends without having to include additional balancing hardware or complex control manipulation. The inverters can conveniently be controlled by using the well-established phase-shifted carrier modulation scheme with only two additional linear references and a mapping logic table needed. Existing modulators can therefore be conveniently retrofitted for controlling the presented inverters. By appropriately coordinating the inverter gating signals, their implementations can be realized by using the least number of components without degrading performance. These enhanced features of the inverters have already been verified in simulation and experimentally using a scaled-down laboratory platform.