gebhart/patrepeval huggingface dataset:
Mechanically patterning the embryonic airway epithelium (2015)

Collections of cells must be patterned spatially during embryonic development to generate the intricate architectures of mature tissues. In several cases, including the formation of the branched airways of the lung, reciprocal signaling between an epithelium and its surrounding mesenchyme helps generate these spatial patterns. Several molecular signals are thought to interact via reaction-diffusion kinetics to create distinct biochemical patterns, which act as molecular precursors to actual, physical patterns of biological structure and function. Here, however, we show that purely physical mechanisms can drive spatial patterning within embryonic epithelia. Specifically, we find that a growth-induced physical instability defines the relative locations of branches within the developing murine airway epithelium in the absence of mesenchyme. The dominant wavelength of this instability determines the branching pattern and is controlled by epithelial growth rates. These data suggest that physical mechanisms can create the biological patterns that underlie tissue morphogenesis in the embryo.
The PCR Suite (2004)

The web application PCR Suite is an extension of the primer design program Primer3. It allows the design of primer sets encompassing single nucleotide polymorphisms, all exons of a single gene, all open reading frames in a list of cDNAs or the creation of overlapping PCR products.
A CORBA based architecture for heterogeneous information source interoperability (2002)

Computational environments are characterized by islands of information. Data is spread throughout the computational system nodes and is controlled by several different data management systems. However, application programs require an integrated view of such data. Thus, it is necessary to build bridges to connect these information islands. Heterogeneous database systems, especially those object-oriented based have been referred to as one of the most viable solutions to the problem of system integration in heterogeneous distributed environments (HDDS). The implementation of such systems is still challenging. This work presents an experience of implementing one of such systems using the CORBA standard as the communication basis in an architecture that uses the concept of HDDS.
Adoptive Immunotherapy for Advanced Non-small Cell Lung Cancer Using Zoledronate-expanded γδ T Cells (2011)

Human γδ T cells can recognize and kill non-small cell lung cancer (NSCLC) cells using the Vγ9Vδ2 T-cell receptor and/or NKG2D. We have established clinical grade large-scale ex vivo expansion of γδ T cells from peripheral blood mononuclear cells by culturing with zoledronate and interleukin-2 (IL-2). A phase I study was conducted to evaluate safety and potential antitumor effects of re-infusing ex vivo expanded γδ T cells in patients with recurrent or advanced NSCLC. Patient's peripheral blood mononuclear cells were stimulated with zoledronate (5 μM) and IL-2 (1000 IU/mL) for 14 days. Harvested cells, mostly γδ T cells, were given intravenously every 2 weeks without additional IL-2, a total of 6 times. The cumulative number of transferred γδ T cells ranged from 2.6 to 45.1 x 10⁹ (median, 15.7×10⁹). Fifteen patients underwent adoptive immunotherapy with these γδ T cells. There were no severe adverse events related to the therapy. Immunomonitoring data showed that with increasing numbers of infusions, the number of peripheral γδ T cells gradually increased. All patients remained alive during the study period with a median survival of 589 days and median progression-free survival of 126 days. According to the Response Evaluation Criteria In Solid Tumors, there were no objective responses. Six patients had stable disease, whereas the remaining 6 evaluable patients experienced progressive disease 4 weeks after the sixth transfer. We conclude that adoptive transfer of zoledronate-expanded γδ T cells is safe and feasible in patients with NSCLC, refractory to other treatments.
Polystyrene Packaging Applications: Foam Sheet and Oriented Sheet (2003)

This chapter contains sections titled: Introduction Oriented Polystyrene Sheet Extruded Polystyrene Foam Sheet References
Novel Metallic Hollow Sphere Structures (2000)

The obvious advantages of metallic hollow sphere materials have lead to several attempts to produce such structures. None of these approaches has gained practical significance owing to the very high cost of the methods. A new powder metallurgical process using styrofoam spheres allows for the production of hollow spheres from arbitrary metals and alloys. The IFAM Department of Powder Metallurgy and Composite Materials, Dresden, has developed this process and added a method that produces random hollow sphere structures (RHS) directly from the green spheres.
40 Gbit/s XOR and AND gates using polarisation switching within 1 m-long bismuth oxide-based nonlinear fibre (2005)

The implementation of all-optical logic gates of XOR and AND operable at 40 Gbit/s using polarisation switching within only 1 m length of a fabricated Bi-NLF is experimentally demonstrated. The two logic functions are obtained in a single device by simply changing the polarisation states of input signals relative to that of a probe beam.
Differentiated Thyroid Carcinoma After <sup>131</sup> I-MIBG Treatment for Neuroblastoma During Childhood: Description of the First Two Cases (2012)

Both these cases of DTC after (131)I-MIBG for childhood NBL underline the importance of adequate thyroid protection against radiation exposure during treatment for NBL. Children who have been treated with (131)I-MIBG should be given life-long follow-up, not only with regard to thyroid function, but also with surveillance for the development of thyroid nodules and thyroid cancer.
AudioDB: Scalable approximate nearest-neighbor search with automatic radius-bounded indexing. (2008)

This talk describes new approximate nearest-neighbor methods employed in a scalable audio-feature database system called “AudioDB.” This open-source system is designed to scale to storing and searching hundreds of millions of feature vectors on standard UNIX workstation platforms. A radius-bounded nearest-neighbor vector-sequence search algorithm, based on locality sensitive hashing (LSH), achieves sublinear retrieval times at this scale. The performance of the LSH-based algorithm depends critically on the choice of radius bound supplied—the wrong value impacts retrieval accuracy or retrieval time. An optimal radius estimator is derived by modeling the minimum value distribution of a random sample of a data set’s pairwise distance distribution. When used with LSH this yields accurate search results with retrieval times several orders of magnitude faster than exhaustive search methods and space-partitioning methods. The same statistical sampling method is used to perform retrieval tasks at successively higher levels of specificity on labeled or unlabeled audio collections. The result is a system that (a) unifies audio retrieval tasks across a range of specificities, using the statistical framework of background distance-distribution sampling and hypothesis testing (b) is as accurate as exhaustive search methods and (c) is three orders of magnitude faster than exhaustive search methods.
Common-Mode Circulating Current Control of Paralleled Interleaved Three-Phase Two-Level Voltage-Source Converters With Discontinuous Space-Vector Modulation (2011)

This paper presents a control method to limit the common-mode (CM) circulating current between paralleled three-phase two-level voltage-source converters (VSCs) with discontinuous space-vector pulsewidth modulation (DPWM) and interleaved switching cycles. This CM circulating current can be separated into two separate components based on their frequency; the high-frequency component, close to the switching frequency, can be effectively limited by means of passive components; the low-frequency component, close to the fundamental frequency, embodies the jumping CM circulating current observed in parallel VSCs. This is the main reason why it is usually recommended not to implement discontinuous and interleaving PWM together. The origin of this low-frequency circulating current is analyzed in detail, and based on this, a method to eliminate its presence is proposed by impeding the simultaneous use of different zero vectors between the converters. This control method only requires six additional switching actions per line cycle, presenting a minimum impact on the converter thermal design. The analysis and the feasibility of the control method are verified by simulation and experimental results.
Concepts and Applications of A 3-D Multiple Lithology, Diffusive Model in Stratigraphic Modeling (1999)

Numerical Experiments in Stratigraphy: Recent Advances in Stratigraphic and Sedimentologic Computer Simulations - This volume presents the results derived from a three-day workshop held at the University of Kansas, Lawrence, Kansas, from May 15 through May 17, 1996. The objectives of the workshop were to document, characterize, demonstrate, and compare different computing procedures that have been utilized in simulating stratigraphic sequences. Both inverse and forward simulation modeling procedures are represented. The results of the workshop and the papers assembled here include: (1) an enhanced understanding of similarities and differences between models and modeling philosophies, (2) increased communication among modeling groups and geoscientists, (3) critical evaluation of applications and assessment of how models have been utilized, and (4) improvements and refinements in techniques for generating and describing model input and output.
Beyond the byzantine generals: unexpected behavior and bridging fault diagnosis (2002)

Physical defects cause behaviors unmodeled by even the best fault simulators, which complicates predictive diagnosis. This paper reports on a diagnosis procedure that uses modified composite signatures constructed from single stuck-at information combined with a lexicographic matching and ranking algorithm. The diagnosis procedure is used to perform high-quality bridging fault diagnosis for more than 400,000 diagnostic experiments involving dropping or adding behaviors from the simulations of faulty circuits.
Transmission performance of monolithically integrated Y-branch tunable laser with zero-chirp Mach-Zehnder modulator (2007)

A zero-chirp Mach-Zehnder modulator monolithically integrated with a widely tunable modulated grating Y laser and SOA, operating at 10 Gbit/s, is demonstrated. The device is hermetically packaged with a wavelength locker within a 12.7times15.24 mm module. With a fixed receiver threshold and fixed voltage modulation depth, the extinction ratio exceeds 12 dB and the receiver penalty for dispersion in the range plusmn800 ps/nm is below 1.5 dB on all channels
Nonlinear-absorbing fiber array for large-dynamic-range optical limiting application against intense short laser pulses (2004)

A complete quantitative description of a nonlinear fiber array for optical limiting application against laser pulses in the picosecond–nanosecond regime is presented. We discuss the dynamics of the molecular photonic processes accompanying the propagation of a laser pulse through the fiber core made of materials that possess reverse saturable absorption, two-photon absorption (TPA), and excited-state absorption (ESA), and we detail the optical limiting effectiveness and limitations of these nonlinear absorption processes individually and in concert. In particular, we demonstrate the importance of excited-state population recycling in extending the dynamic range of the limiting action. Experimental results obtained from a particular fiber core material that possesses TPA and ESA show good agreement with theoretical expectations and demonstrate the optical limiting capability of such a nonlinear fiber array.
CENTRIFUGAL COMPRESSOR MULTI-MODE ROTATING STALL CONTROL (2000)

To maintain stable operation, centrifugal compressors require a sufficient surge margin to avoid instabilities caused by small deviations in operating point or inlet conditions.When the operating point of a compressor nears the surge line, two unstable flow behaviors may exist -rotating stall and surge.The recent efforts in stall control have focused on the suppression of a single resonant mode, or stall cell pattern, to achieve range extension.A critical limitation of these techniques has been the eruption of higher order modes after the successful control of the first stall mode.To address this issue, experiments have been performed at Purdue University to investigate the feasibility of passive control of multi-mode rotating stall in centrifugal compressors.This is accomplished through experiments directed at characterizing the onset of rotating stall under the influence of a passive-dynamic multi-mode control scheme implemented in the Purdue Low Speed Centrifugal Compressor (PLCC).
Pharmacokinetics and safety of trovafloxacin in healthy male volunteers following administration of single intravenous doses of the prodrug, alatrofloxacin (1997)

Fifteen healthy male volunteers (in four groups) received single 1 h i.v. infusions of alatrofloxacin (CP-116,517) equivalent to 30, 100, 200 or 300 mg of its active metabolite, trovafloxacin (CP-99,219). Blood and urine were sampled over 73 and 72 h, respectively, and plasma levels of alatrofloxacin and serum concentrations of trovafloxacin were determined by HPLC with UV detection. Alatrofloxacin was not detectable in plasma samples collected after the end of infusion, indicating rapid conversion to trovafloxacin. Maximum serum concentrations of trovafloxacin were achieved at the end of the infusions. Mean maximum plasma trovafloxacin concentrations for the four alatrofloxacin doses were 0.4, 1.8, 2.3 and 4.3 mg/L. The mean area under the concentration-time curve increased proportionally with the dose. The elimination half-life (T(1/2)) for trovafloxacin was independent of the dose and the mean T(1/2)s for the 100, 200 and 300 mg equivalent doses of alatrofloxacin were 10.4, 12.3 and 10.8 h. Approximately 10% of the equivalent dose was recovered as unchanged trovafloxacin in the urine. No clinical adverse or laboratory reactions were associated with i.v. administration of alatrofloxacin and its conversion to trovafloxacin. These results indicate that alatrofloxacin is rapidly converted to trovafloxacin and that the pharmacokinetic parameters for this new fluoroquinolone after i.v. administration of its parent compound are similar to those reported after oral administration of equivalent trovafloxacin doses.
Continuous wave terahertz systems exploiting 15 µm telecom technologies (2009)

A fiber-assembled CW THz System operating at 1.5 microm is presented. High speed telecom photodiodes integrated with planar THz antennas serve as THz emitters with power up to 10 microW. Photoconductive antennas based on LT InGaAs/InAlAs multi-layer structures allow coherent detection. The system operates in a wide frequency range of 0.1 -1.6 THz.
IN OUR CONTEMPORARIES: 1. In New Zealand Journals…: About the Pacific (1960)

THE COOK ISLANDS: R. G. Crocombe, Post‐Primary School Bulletin VILLAGE LIFE IN FIJI: R. R. Nayacakalou, ibid.
Synthesis and catalytic properties of large-pore Sn-β and Al-free Sn-β molecular sieves (1997)

Sn-β and Al-free Sn-β (large pore, 12-membered ring channels) molecular sieves prepared by hydrothermal synthesis and characterised by XRD, FTIR and sorption techniques are distinguished by their acidic and oxidation properties, in the acetylation of 1,3,5-trimethylbenzene (1,3,5-TMB) with acetyl chloride and in the oxidation of m-cresol and 1,3,5-TMB with aqueous H 2 O 2 , respectively.
Recent advances in hybrids of carbon nanotube network films and nanomaterials for their potential applications as transparent conducting films (2011)

The use of carbon nanotubes (CNTs) as transparent conducting films is one of the most promising aspects of CNT-based applications due to their high electrical conductivity, transparency, and flexibility. However, despite many efforts in this field, the conductivity of carbon nanotube network films at high transmittance is still not sufficient to replace the present electrodes, indium tin oxide (ITO), due to the contact resistances and semi-conducting nanotubes of the nanotube network films. Many studies have attempted to overcome such problems by the chemical doping and hybridization of conducting guest components by various methods, including acid treatment, deposition of metal nanoparticles, and the creation of a composite of conducting polymers. This review focuses on recent advances in surface-modified carbon nanotube networks for transparent conducting film applications. Fabrication methods will be described, and the stability of carbon nanotube network films prepared by various methods will be demonstrated.
Microdamage and mechanical behaviour: predicting failure and remodelling in compact bone (2003)

This paper reports on the development of a theoretical model to simulate the growth and repair of microdamage in bone. Unlike previous theories, which use simplified descriptions of damage, this approach models each individual microcrack explicitly, and also models the basic multicellular units (BMUs) that repair cracks. A computer simulation has been developed that is capable of making a variety of predictions. Firstly, we can predict the mechanical behaviour of dead bone in laboratory experiments, including estimates of the number of cycles to failure and the number and length of microcracks during fatigue tests. Secondly, we can predict the results of bone histomorphometry, including such parameters as BMU activation rates and the changing ratio of primary to secondary bone during ageing. Thirdly, we can predict the occurrence of stress fractures in living bone: these occur when the severity of loading is so great that cracks grow faster than they can be repaired. Finally, we can predict the phenomenon of adaptation, in which bone is deposited to increase cortical thickness and thus prevent stress fractures. In all cases results compare favourably with experimental and clinical data.
In Vivo Administration of a JAK3 Inhibitor to Chronically SIV Infected Rhesus Macaques Leads to NK Cell Depletion Associated with Transient Modest Increase in Viral Loads (2013)

Innate immune responses are reasoned to play an important role during both acute and chronic SIV infection and play a deterministic role during the acute stages on the rate of infection and disease progression. NK cells are an integral part of the innate immune system but their role in influencing the course of SIV infection has been a subject of debate. As a means to delineate the effect of NK cells on SIV infection, use was made of a Janus kinase 3 (JAK3) inhibitor that has previously been shown to be effective in the depletion of NK cells in vivo in nonhuman primates (NHP). Extensive safety and in vitro/in vivo PK studies were conducted and an optimal dose that depletes NK cells and NK cell function in vivo identified. Six chronically SIV infected rhesus macaques, 3 with undetectable/low plasma viral loads and 3 with high plasma viral loads were administered a daily oral dose of 10 mg/kg for 35 days. Data obtained showed that, at the dose tested, the major cell lineage affected both in the blood and the GI tissues were the NK cells. Such depletion appeared to be associated with a transient increase in plasma and GI tissue viral loads. Whereas the number of NK cells returned to baseline values in the blood, the GI tissues remained depleted of NK cells for a prolonged period of time. Recent findings show that the JAK3 inhibitor utilized in the studies reported herein has a broader activity than previously reported with dose dependent effects on both JAK2 and JAK1 suggests that it is likely that multiple pathways are affected with the administration of this drug that needs to be taken into account. The findings reported herein are the first studies on the use of a JAK3 inhibitor in lentivirus infected NHP.
Mebendazole (r—17,635): A new anthelmintic in the development of hookworms (1971)

Journal Article Mebendazole (r—17,635): A new anthelmintic in the development of hookworms Get access Debiprasad Banerjee, Debiprasad Banerjee Section of Parasitology, Department of Microbiology, All India Institute of Medical Sciences, New Delhi-16 India Search for other works by this author on: Oxford Academic PubMed Google Scholar Anandita Mandal, Anandita Mandal Section of Parasitology, Department of Microbiology, All India Institute of Medical Sciences, New Delhi-16 India Search for other works by this author on: Oxford Academic PubMed Google Scholar Om Prakash Om Prakash Section of Parasitology, Department of Microbiology, All India Institute of Medical Sciences, New Delhi-16 India Search for other works by this author on: Oxford Academic PubMed Google Scholar Transactions of The Royal Society of Tropical Medicine and Hygiene, Volume 65, Issue 5, 1971, Pages 685–686, https://doi.org/10.1016/0035-9203(71)90061-7 Published: 01 January 1971
Cyclization of D-xylo-hexos-5-ulose, chemical synthesis of scyloo- and myo-insoitols from D-glucose (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCyclization of D-xylo-hexos-5-ulose, chemical synthesis of scyloo- and myo-insoitols from D-glucoseDonald E. Kiely and Hewitt G. Fletcher Jr.Cite this: J. Org. Chem. 1969, 34, 5, 1386–1390Publication Date (Print):May 1, 1969Publication History Published online1 May 2002Published inissue 1 May 1969https://pubs.acs.org/doi/10.1021/jo01257a042https://doi.org/10.1021/jo01257a042research-articleACS PublicationsRequest reuse permissionsArticle Views132Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts