gebhart/patrepeval huggingface dataset:
Scripps Institution of Oceanography Contributions Index Vols. 52-71, 1982-2001 (2003)

These citations were published in the Scripps Institution of Oceanography Contributions from volumes 52-71, 1982-2001. Submission of publications to the Contributions by Scripps authors was voluntary, so these citations do not comprise an institutional bibliography for these years. The SIO Contributions ceased with volume 71. These citations are not arranged in any order, either chronologically or by author. A quick glance can mislead the reader to assume that there is order, but it is due to the compilation of these citations from individual files. Use PDF document searching cababilities to search this bibliography.
Memory impairment and schizophrenia: the role of processing speed (1998)

A link between slowing of processing speed and cognitive disorders, including memory, has repeatedly been found in research on aging, and suggested in other cognitively impaired populations. We tested the hypothesis that a link between memory impairment and slowing of processing speed would also be observed in schizophrenia. Forty-four schizophrenic patients and 40 normal controls were administered a memory task involving free recall and recognition. Processing speed was assessed by the Digit Symbol Substitution Test. Working memory span was assessed as well. The measure of processing speed was consistently correlated with the various memory measures in patients, including efficiency of encoding. These correlations remained significant, or tended to be significant, when working memory span was partialled out. Memory deficits observed in schizophrenia may thus be partly accounted for by a slowing of processing speed. It is suggested that research on cognitive deficits in this and other mental diseases focus more on processing speed.
Single layer nitride capacitor dielectric film and high concentration doping technology for 1 Gb/4 Gb trench-type DRAMs (2002)

We propose a novel CVD-SiN deposition process for Single layer Nitride film using SiCl/sub 4/ as the source material to reduce the Si-H bond in the SiN film and a high concentration doping process from vapor phase into a deep trench side-wall. Combining both technologies, an equivalent film thickness for 1 G/4 Gbit DRAM is successfully reduced below 4.0 nm without especial high dielectric constant materials.
Electronic Guidebooks and Visitor Attention. (2001)

We describe an electronic guidebook prototype and report on a study of its use in a historic house. Supported by mechanisms in the guidebook, visitors constructed experiences that had a high degree of interaction with three entities: the guidebook, their companions, and the house and its contents. In this paper, we report a qualitative analysis of how different properties of the guidebook helped or hindered visitors&apos; attempts to balance the competing demands of these attentional entities. Based on the visitors&apos; comments and behavior, we distill a set of design principles.
Automatic learning of dialogue strategy using dialogue simulation and reinforcement learning (2002)

This paper describes a method for automatic design of human-computer dialogue strategies by means of reinforcement learning, using a dialogue simulation tool to model the user behaviour and system recognition performance. To the authors' knowledge this is the first application of a detailed simulation tool to this problem. The simulation tool is trained on a corpus of real user data. Compared to direct state transition modelling, it has the major advantage that different state space representations can be studied without collecting more training data.

We applied Q-learning with eligibility traces to obtain policies for a telephone-based cinema information system, comparing the effect of different state space representations and evaluation functions. The policies outperformed handcrafted policies that operated in the same restricted state space, and gave performance similar to the original design that had been through several iterations of manual refinement.
Collaborative study to establish the first international standard for quantitation of anti‐HPA‐1a (2005)

Laboratories can use this standard to measure the anti-HPA-1a activity in patient's samples. Further studies are required to determine the relationship between anti-HPA-1a activity and clinical outcome in patients with neonatal alloimmune thrombocytopenia (NAIT).
Atomic vapor cells for chip-scale atomic clocks with improved long-term frequency stability (2005)

A novel technique for microfabricating alkali atom vapor cells is described in which alkali atoms are evaporated into a micromachined cell cavity through a glass nozzle. A cell of interior volume 1 mm3, containing 87Rb and a buffer gas, was made in this way and integrated into an atomic clock based on coherent population trapping. A fractional frequency instability of 6 x 10(-12) at 1000 s of integration was measured. The long-term drift of the F=1, mF=0-->F=2, mF=0 hyperfine frequency of atoms in these cells is below 5 x 10(-11)/day.
Immobilized Metal Affinity Chromatography Revisited: pH/Acid Control toward High Selectivity in Phosphoproteomics (2008)

Despite recent advances in instrumentation and analytical strategies for identification and quantitation of protein phosphorylation, a highly specific enrichment protocol is still a challenge in large-scale studies. Here, we report a simple pH/acid control method that addresses the poor specificity seriously criticized in IMAC. Detailed evaluation of the capture and release mechanism in IMAC revealed that pH, buffer and salt yield a complex interplay in enrichment of phosphopeptides, yet they play individual roles in recovery and specificity. A revised one-step IMAC method with low sample loss and high specificity can be rationally designed by controlling salt, pH and the structure and concentration of organic acid. Without methyl esterification, the one-step IMAC enrichment with single LC-MS/MS identified 386 phosphoproteins in 550 mug of non-small-cell lung cancer cell lysate with 96% specificity. Additional fractionation by SDS-PAGE from 4 mg of cell lysate revealed the comprehensive proteome map, identifying 2747 phosphorylation sites from 2360 nondegenerate phosphopeptides and 1219 phosphoproteins with a false discovery rate of 0.63%. To our knowledge, this pH/acid-controlled IMAC procedure provides higher specificity than any other one-step IMAC purification procedure. Furthermore, the simple and reproducible IMAC protocol can be adapted to other solid supports, fully automated or manual, for large-scale identification of the vastly under-explored phosphoproteome.
Olefinic C–H functionalization through radical alkenylation (2015)

Direct olefinic C-H functionalization represents the ideal way of introducing an alkenyl group into organic molecules. A well-known process is the Heck reaction, which involves alkene insertion and β-hydride elimination in the presence of a transition metal. However, the traditional Heck reaction mainly deals with the alkenylation of aryl or vinyl electrophiles. Recent developments have revealed that alkenylation can also be achieved through radical addition to alkenes and following single-electron-transfer (SET) oxidation/elimination. The radical alkenylation pathway allows alkenylation with a variety of carbon-centered radicals and even heteroatom-centered radicals. This tutorial review gives an overview of recent advances in this emerging field.
Stromal Cell–Derived Factor-1α and CXCR4 Expression in Hemangioblastoma and Clear Cell-Renal Cell Carcinoma: von Hippel-Lindau Loss-of-Function Induces Expression of a Ligand and Its Receptor (2005)

The genetic hallmark of hemangioblastomas and clear cell-renal cell carcinomas (CC-RCCs) is loss-of-function of the von Hippel-Lindau (VHL) tumor suppressor protein. VHL is required for oxygen-dependent degradation of hypoxia-inducible factor-1alpha (HIF-1alpha). In hemangioblastomas and CC-RCCs, HIF-1alpha is constitutively overexpressed leading to increased transcription of HIF-1-regulated genes, including vascular endothelial growth factor (VEGF). Because loss of VHL function is associated with increased expression of the chemokine receptor CXCR4 in CC-RCCs, we investigated the expression of HIF-1alpha, CXCR4, and its ligand stromal cell-derived factor-1alpha (SDF-1alpha) in hemangioblastomas and CC-RCCs. Immunohistochemistry revealed overexpression of both CXCR4 and SDF-1alpha within tumor cells and endothelial cells of hemangioblastomas and CC-RCCs. HIF-1alpha was detected in tumor cell nuclei of both hemangioblastomas and CC-RCCs. A specific ELISA showed that hemangioblastomas and CC-RCCs expressed SDF-1alpha protein at levels that were significantly higher than those found in normal tissue. Analysis of the VHL-null RCC line 786-0 revealed that SDF-1alpha mRNA levels were 100-fold higher than in a subclone transfected with the wild-type VHL gene. Expression of CXCR4 and SDF-1alpha mRNA was significantly decreased in HIF-1alpha-null compared with wild-type mouse embryo fibroblasts (MEFs). ELISA and Western blot studies for SDF-1alpha and CXCR4 protein expression confirmed the RNA findings in RCC lines and MEFs. These results suggest that loss-of-function of a single tumor suppressor gene can up-regulate the expression of both a ligand and its receptor, which may establish an autocrine signaling pathway with important roles in the pathogenesis of hemangioblastoma and CC-RCC.
High voltage amplifier (2003)

In typical ion trap experiments, two or more electrodes are drive by sine waves. Their amplitude and frequency determine the atomic mass (amu) of the particles to be trapped. Thus, by sweeping one of those two parameters, a continuous mass-to-charge ratio of the sample can be obtained. Frequency sweep is preferred because in the voltage sweep, the higher the mass measured, the less resolution one gets. Frequency sweeps are limited by the signal generators available. For heavier organic molecules, peak-to-peak voltages as high as 1000 volts and frequencies up to 100 kHz are desirable. Unfortunately there are not too many instruments that can fulfill this task. This paper describes the design, construction and testing of a high voltage amplifier created specifically for this kind of experiment The outcome is a general purpose amplifier that can deliver up to 100 mA of current at 1000 V peak-to-peak, from DC to 100 kHz.
Gene Expression Profiling of Liposarcoma Identifies Distinct Biological Types/Subtypes and Potential Therapeutic Targets in Well-Differentiated and Dedifferentiated Liposarcoma (2007)

Classification of liposarcoma into three biological types encompassing five subtypes, (a) well-differentiated/dedifferentiated, (b) myxoid/round cell, and (c) pleomorphic, based on morphologic features and cytogenetic aberrations, is widely accepted. However, diagnostic discordance remains even among expert sarcoma pathologists. We sought to develop a more systematic approach to liposarcoma classification based on gene expression analysis and to identify subtype-specific differentially expressed genes that may be involved in liposarcoma genesis/progression and serve as potential therapeutic targets. A classifier based on gene expression profiling was able to distinguish between liposarcoma subtypes, lipoma, and normal fat samples. A 142-gene predictor of tissue class was derived to automatically determine the class of an independent validation set of lipomatous samples and shows the feasibility of liposarcoma classification based entirely on gene expression monitoring. Differentially expressed genes for each liposarcoma subtype compared with normal fat were used to identify histology-specific candidate genes with an in-depth analysis of signaling pathways important to liposarcoma pathogenesis and progression in the well-differentiated/dedifferentiated subset. The activation of cell cycle and checkpoint pathways in well-differentiated/dedifferentiated liposarcoma provides several possible novel therapeutic strategies with MDM2 serving as a particularly promising target. We show that Nutlin-3a, an antagonist of MDM2, preferentially induces apoptosis and growth arrest in dedifferentiated liposarcoma cells compared with normal adipocytes. These results support the development of a clinical trial with MDM2 antagonists for liposarcoma subtypes which overexpress MDM2 and show the promise of using this expression dataset for new drug discovery in liposarcoma.
Effect of Lithium Salt on the Stability of Dispersions of Fumed Silica in the Ionic Liquid BMImBF<sub>4</sub> (2012)

We have investigated the stability and interactions in dispersions of colloidal fumed silica, Aerosil 200, and the ionic liquid 1-butyl-3-methylimidazolium tetraflouroborate (BMImBF(4)) as a function of the Li salt concentration (LiBF(4)). Photon correlation spectroscopy was used to study the aggregation behavior at low silica concentrations, and Raman spectroscopy was used to investigate the interactions in the ionic liquid and with the silica surface. We find that the addition of LiBF(4) increases the stability of the dispersions, with smaller agglomerates of silica particles and higher gelation concentrations in the presence of Li salt. The increased stability with the addition of Li salt is explained by the formation of a more stable solvation layer, where Li ions accumulate on the surface. This leads to an increased interaction between lithium ions and the BF(4)(-) anions in the solvation layer, as seen by Raman spectroscopy. Upon gelation, the Li ions are expelled from the surface because hydrogen bonding between the silica particles are formed. For both neat BMImBF(4) and Li-salt-doped BMImBF(4)/silica dispersions, a weak gel phase was found preceding the formation of a strong gel at slightly higher silica concentrations.
Case Report: Immune-mediated Complete Response in a Patient With Recurrent Advanced Ewing Sarcoma (EWS) After Vigil Immunotherapy (2017)

Ewing sarcoma is a highly resistant disease with a <10% chance of survival at 5 years after failure of frontline chemotherapy. This is a case report of an Ewing sarcoma patient with metastatic disease recurrence <2 years after standard chemotherapy/radiation who achieved a durable and sustained complete response after 2 series of treatments with Vigil (GMCSF/bi-shRNA furin DNA autologous tumor immunotherapy) serially manufactured from first and second recurrences with ELISPOT assay correlation. Results support justification of further testing of Vigil with ELISPOT assay as a biomarker to assess level of immune response and correlation with disease control.
Optimized interconnection of disjoint wireless sensor network segments using K mobile data collectors (2012)

Due to harsh environmental conditions a Wireless Sensor Network (WSN) may suffer from large scale damage where many nodes fail simultaneously and thus the network gets partitioned into several disjoint network segments. Restoring intersegment connectivity is essential to avoid negative effects on the application. Employing mobile data collectors (MDCs), which by repositioning-facilitate the establishment of communication links between segments, may provide flexible solution to this problem. However the problem of finding shortest tours for MDCs is NP-Hard. In this paper we study the problem under constrained number of MDCs which makes the problem more challenging. We present a polynomial time heuristic for Interconnecting Disjoint Segments with k MDCs (IDM-kMDC). IDM-kMDC opts to minimize the tour lengths and balance the load on the k available MDCs. We model each segment by a representative. The IDM-kMDC heuristic finds k-subsets of representatives, computes an optimized tour for each subset and assigns one MDC for each tour. The performance of the algorithm is validated through simulation.
[Microsurgical reconstruction of the forearm tendons]. (1989)

The authors analyse their clinical experience of treating 5 patients with immobilization of the hand and propose to use complex and composite vascularized grafts for the plasty of extensive defects of tendons and skin of the forearm. They consider microvascular grafting of skin flaps from the back of the foot with tendons from the extensors of the toes with their own paratenon to be an excellent material for the reconstruction of the tendons of the flexors. They advise to use the vascularized broad fascia of the hip incorporated into the lateral flap from the hip for the plasty of extensive defects of the tendons of the extensors. The authors point out that the indications for using a combined graft from the back of the foot carrying vascularized tendons require further elaboration.
Is the hand of God involved in human cooperation? (2009)

Purpose The purpose of this paper is to examine the supernatural punishment theory . The theory postulates that religion increases cooperation because religious people fear the retributions that may follow if they do not follow the rules and norms provided by the religion. Design/methodology/approach The paper reports results for a public goods experiment conducted in India, Mexico, and Sweden. By asking participants whether they are religious or not, one can study whether religiosity has an effect on voluntary cooperation in the public goods game. Findings No significant behavioral differences were found between religious and nonreligious participants in the experiment. Originality/value This paper differs from the previous limited experimental literature, studying religiosity and cooperation, in the sense that it uses a public goods game rather than a prisoner's dilemma game. The public goods game is more interesting since many real life problems are multilateral rather than bilateral. Further, the study was conducted in three different countries: India, Mexico, and Sweden; with three different types of potentialy religious people: Hindus, Catholics, and Protestants.
Geometric Modeling with Splines (2001)

Written by researchers who have helped found and shape the field, this book is a definitive introduction to geometric modeling. The authors present all of the necessary techniques for curve and surface representations in computer-aided modeling with a focus on how the techniques are used in design.
Listening In (1981)

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Preparation and Characterization of Methylsilsesquioxane Thin Film Containing Tris(ethylenediamine)cobalt(III) Chloride as a Photobase Generator (2010)

Porous methylsilsesquioxane thin films were prepared using the sol−gel process, with tris(ethylenediamine)cobalt(III) chloride (Co(en)3Cl3) as a photobase generator and polypropylene glycol (PPG) as a template. The generation of amines was confirmed for more than 2 min of ultraviolet (UV) irradiation. The prepared film with the UV irradiation and subsequent heat treatment showed a low refractive index of n = 1.35. Subsequent field-emission scanning electron microscopy (FE-SEM) observations confirmed that shrinkage of the film with the heat treatment was suppressed in the film with UV irradiation. The photogenerated amines from Co(en)3Cl3 worked as a catalyst for the condensation reaction in the gel films during the initial stage of heat treatment. A porous structure was obtained using the thermal decomposition of PPG without collapse of the gel network.
Progress towards construction of a total restriction fragment map of a human chromosome (1987)

We present an approach to the construction of an overlapping restriction fragment map of a single human chromosome. A genomic cosmid library genome was constructed from a mouse-human hybrid cell line containing chromosome 17 as its only human genetic component. Cosmids containing human inserts were isolated by hybridisation to a human Alu sequence. DNAs from ninety-six randomly chosen cosmids were digested with either EcoRI or HindIII, end-labelled with 35S-dATP and analysed using agarose gel electrophoresis. Comparison of the restriction fragment patterns revealed two pairs of overlapping clones, that were confirmed by cross-hybridization of the overlapping fragments. The two pairs of cosmids both mapped to human chromosome 17, as shown by hybridization to a panel of somatic cell hybrids. These data demonstrate that the generation of an overlapping cosmid map along a human chromosome is feasible, representing an intermediate step towards the complete sequencing of a human chromosome.
High-density multilayer optical disc storage (2006)

High-density multilayer optical disc storage was investigated by employing advanced signal processing methods such as adaptive equalization and adaptive partial-response maximum-likelihood (PRML) detection. Preliminary experiments, recording on single-layer and dual-layer Blu-ray discs (BD), indicate storage capability of 33.3 GB/layer with adaptive 5-tap PRML. A new signal qualification method, sequenced amplitude margin quasi-error estimation (SAMQES), was introduced for high-density multilayer recording, and possibility toward a total storage capacity of 200 GB was examined by using a six-layer BD-Recordable disc. Despite coherent interlayer crosstalk and lower signal-to-noise ratio, SAMQES showed moderate increase from those in single-layer recording.
Fiber-Optic Technology Allows Real-Time Production Logging Well Campaign To Continue Where Traditional Logging Tools Fell Short (2012)

Abstract Exploration and exploitation of the shale formations in the United States has continued to accelerate since the early 2000's. Once considered to exist only as a cap rock, shale is now proving to be one of the most important reservoir rocks in North America and throughout the world. The demand for production logging (PL) in these reservoirs has increased due to the desire to better understand the basis behind higher stimulation efficiency and increased production results. Data collected via production logs can be used to evaluate efforts to enhance production through better zonal targeting, modifications to completion/hydraulic fracture design and/or alternate zonal isolation procedures. Drilling extended reach horizontal wells has allowed for more efficient exploitation of these formations but has also increased the number of potential obstacles to overcome in order to obtain complete and accurate production logs. Some of these obstacles include: severe doglegs which interfere with logging tool bending capability, substantial wellbore debris and/or added friction surface contact impacting depth of data capture, and completion configurations that limit equipment options and ease of logging. This paper will identify these critical factors and address proper candidate well selection and job preparation. It will also illustrate a multi-well logging campaign in the Marcellus shale, which highlights the benefits of fiber optic technology as a suitable alternative to traditional production logging techniques.
Recent Developments in Optical Wireless Communications using Infrared and Visible Light (2007)

For future short-range applications, optical wireless communications present a viable and promising supplemental technology to radio wireless systems. This contribution presents a review of infrared and visible light optical wireless indoor communications, including basics, state of the art, challenges and prospects. Advanced approaches based on diversity techniques and adaptive signal processing show potential to achieve both high spatial coverage and high bit rates of more than 100 Mb/s.