gebhart/patrepeval huggingface dataset:
Valproic Acid II: Effects on Oxidative Stress, Mitochondrial Membrane Potential, and Cytotoxicity in Glutathione-Depleted Rat Hepatocytes (2005)

Oxidative stress has been associated with valproic acid (VPA) treatment, and mitochondrial dysfunction has been implicated in the pathogenesis of VPA-idiosyncratic hepatotoxicity. The present study investigated the effect of VPA and the role of GSH on oxidative stress, mitochondrial membrane potential, and toxicity in freshly isolated rat hepatocytes. Hepatocytes were isolated from Sprague-Dawley rats, and total levels of glutathione (GSH) reduced by pretreatment with a combination of L-buthionine sulfoximine (2 mM) and diethylmaleate (0.5 mM) prior to VPA (0-1000 microg/ml) treatment. Oxidative stress was determined by measuring the levels of 15-F(2t)-isoprostane (15-F(2t)-IsoP) and 2',7'-dichlorofluorescein (DCF). Mitochondrial membrane potential (Deltapsi(m)) was determined by using the dual-fluorescent dye JC-1, and cell viability was evaluated by the water-soluble tetrazolium salt WST-1 assay. Exposure of rat hepatocytes to VPA (0-1000 mug/ml) resulted in a time- and dose-dependent increase in 15-F(2t)-IsoP and DCF fluorescence, and these levels were further elevated in GSH-reduced hepatocytes. In control hepatocytes, VPA had no effect on cell viability; however, significant cytotoxicity was observed in the glutathione-depleted hepatocytes treated with 1000 mug/ml VPA. The Deltapsi(m) was only reduced in glutathione-reduced hepatocytes at 500 and 1000 microg/ml VPA. Our novel findings indicate that acute treatment of freshly isolated rat hepatocytes with VPA resulted in oxidative stress, which occurred in the absence of cytotoxicity, and that glutathione confers protection to hepatocytes against mitochondrial damage by VPA.
Cell culture and somatic cell genetics of plants (1984)

Cell culture and somatic cell genetics of plants , Cell culture and somatic cell genetics of plants , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی
Reduction of the Loss in Ferrite Materials in the Microwave Region (1953)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation H. N. Chait, N. G. Sakiotis, R. E. Martin; Reduction of the Loss in Ferrite Materials in the Microwave Region. J. Appl. Phys. 1 January 1953; 24 (1): 109–110. https://doi.org/10.1063/1.1721119 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioJournal of Applied Physics Search Advanced Search |Citation Search
Development of a Molecular Recognition Ion Gating Membrane and Estimation of Its Pore Size Control (2002)

We have fabricated a molecular recognition ion gating membrane. This synthetic membrane spontaneously opens and closes its pores in response to specific solvated ions. In addition to this switching function, we found that this membrane could control its pore size in response to a known concentration of a specific ion. The membrane was prepared by plasma graft copolymerization, which filled the pores of porous polyethylene film with a copolymer of NIPAM (N-isopropylacrylamide) and BCAm (benzo[18]crown-6-acrylamide). NIPAM is well-known to have an LCST (lower critical solution temperature), at which its volume changes dramatically in water. The crown receptor of the BCAm traps a specific ion, and causes a shift in the LCST. Therefore, selectively responding to either K(+) or Ba(2+), the grafted copolymer swelled and shrank in the pores at a constant temperature between two LCSTs. The solution flux in the absence of Ba(2+) decreased by about 2 orders of magnitude over a solution flux containing Ba(2+). The pore size was estimated by the filtration of aqueous dextran solutions with various solute sizes. This revealed that the membrane changed its pore size between 5 and 27 nm in response to the Ba(2+) concentration changes. No such change was observed for Ca(2+) solutions. Furthermore, this pore size change occurred uniformly in all pores, as a clear cut-off value for a solute size that could pass through pores was always present. This membrane may be useful not only as a molecular recognition ion gate, but also as a device for spontaneously controlling the permeation flux and solute size.
Fast Deep Neural Networks With Knowledge Guided Training and Predicted Regions of Interests for Real-Time Video Object Detection (2018)

It has been recognized that deeper and wider neural networks are continuously advancing the state-of-the-art performance of various computer vision and machine learning tasks. However, they often require large sets of labeled data for effective training and suffer from extremely high computational complexity, preventing them from being deployed in real-time systems, for example vehicle object detection from vehicle cameras for assisted driving. In this paper, we aim to develop a fast deep neural network for real-time video object detection by exploring the ideas of knowledge-guided training and predicted regions of interest. Specifically, we will develop a new framework for training deep neural networks on datasets with limited labeled samples using cross-network knowledge projection which is able to improve the network performance while reducing the overall computational complexity significantly. A large pre-trained teacher network is used to observe samples from the training data. A projection matrix is learned to project this teacher-level knowledge and its visual representations from an intermediate layer of the teacher network to an intermediate layer of a thinner and faster student network to guide and regulate the training process. To further speed up the network, we propose to train a low-complexity object detection using traditional machine learning methods, such as support vector machine. Using this low-complexity object detector, we identify the regions of interest that contain the target objects with high confidence. We obtain a mathematical formula to estimate the regions of interest to save the computation for each convolution layer. Our experimental results on vehicle detection from videos demonstrated that the proposed method is able to speed up the network by up to 16 times while maintaining the object detection performance.
Étude des couches minces et des surfaces par réflexion rasante, spéculaire ou diffuse, de rayons X (1976)

Nous savons que les équations de Fresnel appliquées à des dioptres supposés, parfaitement plans et homogènes, ne permettent pas de rendre compte des courbes de réflexion spéculaire fournies par des échantillons massifs ou en couche mince. Nos considérations sur divers processus de diffusion élastique ou inélastique, montrent que seule la diffusion élastique introduite par les irrégularités ou inhomogénéités de surface est importante pour l'analyse de ces courbes. Nous proposons quelques modèles de rugosité et en précisons les domaines de validité aussi bien pour la réflexion spéculaire, que pour la réflexion diffuse (suivant la loi des réseaux). Ces modèles sont comparés avec les courbes expérimentales obtenues sur des échantillons massifs de titane, de silicium et de germanium, avec les rayonnements Kα 1 du cuivre ou du chrome.
Ultraflexible and tailorable all-solid-state supercapacitors using polyacrylamide-based hydrogel electrolyte with high ionic conductivity (2017)

Hydrogels with high ionic conductivity consisting of a cross-linked polymer network swollen in water are very promising to be used as an electrolyte for all-solid-state supercapacitors. However, there are rather few flexible supercapacitors using ionic conducting hydrogel electrolytes reported to date. In this work, highly flexible and ionic conducting polyacrylamide hydrogels were synthesized through a simple approach. On using the ionic hydrogels as the electrolyte, the resulting supercapacitors not only exhibited a high specific capacitance but also showed a long self-discharge time (over 10 hours to the half of original open-circuit voltage) and a low leakage current. These newly-developed all-solid-state supercapacitors can be bent, knot, and kneaded for 5000 cycles without performance decay, suggesting excellent flexibility and mechanical stability. These all-solid-state supercapacitors can also be easily tailored into strip-like supercapacitors without a short circuit, which provides an efficient approach to fabricate wearable energy storage devices.
Computational Analysis and Prediction of the Binding Motif and Protein Interacting Partners of the Abl SH3 Domain (2006)

Protein-protein interactions, particularly weak and transient ones, are often mediated by peptide recognition domains, such as Src Homology 2 and 3 (SH2 and SH3) domains, which bind to specific sequence and structural motifs. It is important but challenging to determine the binding specificity of these domains accurately and to predict their physiological interacting partners. In this study, the interactions between 35 peptide ligands (15 binders and 20 non-binders) and the Abl SH3 domain were analyzed using molecular dynamics simulation and the Molecular Mechanics/Poisson-Boltzmann Solvent Area method. The calculated binding free energies correlated well with the rank order of the binding peptides and clearly distinguished binders from non-binders. Free energy component analysis revealed that the van der Waals interactions dictate the binding strength of peptides, whereas the binding specificity is determined by the electrostatic interaction and the polar contribution of desolvation. The binding motif of the Abl SH3 domain was then determined by a virtual mutagenesis method, which mutates the residue at each position of the template peptide relative to all other 19 amino acids and calculates the binding free energy difference between the template and the mutated peptides using the Molecular Mechanics/Poisson-Boltzmann Solvent Area method. A single position mutation free energy profile was thus established and used as a scoring matrix to search peptides recognized by the Abl SH3 domain in the human genome. Our approach successfully picked ten out of 13 experimentally determined binding partners of the Abl SH3 domain among the top 600 candidates from the 218,540 decapeptides with the PXXP motif in the SWISS-PROT database. We expect that this physical-principle based method can be applied to other protein domains as well.
Evaluation of a heuristic approach for efficient scheduling of residential smart home appliances (2015)

Load scheduling will play an important role in achieving Demand Response (DR) at the consumption level of the emerging smart grid. This paper presents the evaluation of a heuristic approach for scheduling residential smart home appliances. The proposed heuristic schedules appliances one after the other in accordance with a greedy strategy without backtracking. This is such that the worst-case computation time is reduced compared to an exact search, at the expense of a potential loss of optimality in the obtained solution. In this paper the performance of the proposed heuristic is evaluated against an exact algorithm across the course of a full year using representative hourly prices of electricity. The results verify the suitability of the algorithm for the implementation of residential energy management decision support system.
Reducing Amyloid-Related Alzheimer's Disease Pathogenesis by a Small Molecule Targeting Filamin A (2012)

PTI-125 is a novel compound demonstrating a promising new approach to treating Alzheimer's disease (AD), characterized by neurodegeneration and amyloid plaque and neurofibrillary pathologies. We show that the toxic signaling of amyloid-β(42) (Aβ(42)) by the α7-nicotinic acetylcholine receptor (α7nAChR), which results in tau phosphorylation and formation of neurofibrillary tangles, requires the recruitment of the scaffolding protein filamin A (FLNA). By binding FLNA with high affinity, PTI-125 prevents Aβ(42)'s toxic cascade, decreasing phospho-tau and Aβ aggregates and reducing the dysfunction of α7nAChRs, NMDARs, and insulin receptors. PTI-125 prevents Aβ(42) signaling by drastically reducing its affinity for α7nAChRs and can even dissociate existing Aβ(42)-α7nAChR complexes. Additionally, PTI-125 prevents Aβ-induced inflammatory cytokine release by blocking FLNA recruitment to toll-like receptor 4, illustrating an anti-inflammatory effect. PTI-125's broad spectrum of beneficial effects is demonstrated here in an intracerebroventricular Aβ(42) infusion mouse model of AD and in human postmortem AD brain tissue.
Panchromatic ternary/quaternary polymer/fullerene BHJ solar cells based on novel silicon naphthalocyanine and silicon phthalocyanine dye sensitizers (2016)

<bold>SiNC-1</bold>is successfully applied in ternary/quaternary devices, accompanied by charge transfer/transport mechanism studies.
One-year safety and tolerability profile of pridopidine in patients with Huntington disease (2013)

This study provides Class IV evidence that pridopidine (≤90 mg/day) is generally safe and well-tolerated in patients with Huntington disease for up to 1 year.
Expression of the H2-E molecule mediates protection to collagen-induced arthritis in HLA-DQ8 transgenic mice: role of cytokines (1997)

Transgenic mice expressing DQA1*0301 and DQB1*0302 (HLA-DQ8) molecules in class II-deficient Ab degree mice are susceptible to collagen-induced arthritis (CIA). To evaluate the role of the H2-E molecule (a homolog of HLA-DR) in DQ-restricted arthritis, the H2-E gene was introduced into DQ8.Ab degree mice to generate DQ8/E+.Ab degree mice. Expression of the E molecule protects DQ8.Ab degree mice against arthritis. In vitro studies using draining lymph nodes from mice primed with bovine type II collagen (BII) showed that the response to BII in both transgenics is DQ and CD4 restricted. Challenge with BII in vitro leads to production of high levels of IFN-gamma in DQ8 and IL-4 in DQ8/E+ mice. We have hypothesized that the H2-E molecule modulates the T cell repertoire and changes the cytokine balance, resulting in protection of disease.
Delay-optimal wiring plan for the microprocessor of high performance computing machines (2000)

This paper presents a delay-optimal designing method for high performance microprocessor. In order to develop such a microprocessor in short period, a novel planning method for global wires, called "wiring plan" has been introduced. The goal of this wiring plan is to solve timing issue of wires with minimum usage of wiring resources; wiring channels and inserted buffers. In this wiring plan, global assignment of wiring resources and improvement of local congestion for their usage have been done. As a result of applying them, our chip has been able to work at 400MHz, and channel usage has not exceeded its capacity and gate overhead for buffer insertions has been only 1.6% of total gates.
Offset and angle-domain common image-point gathers for shot-profile migration (2002)

Abstract Prestack depth migration of shot profiles by downward continuation is a practical imaging algorithm that is especially cost-effective for sparse-shot wide-azimuth geometries. The interpretation of offset as the displacement between the downward-propagating (shot) wavefield and upward-propagating (receiver) wavefield enables us to extract offset-domain common image-point (CIP) gathers during shot-profile migration. The offset-domain gathers can then be transformed to the angle domain with a radial-trace mapping originally introduced for shot-geophone migration. The computational implications of this procedure include both the additional cost of multioffset imaging and an implicit transformation from shot-geophone to midpoint-offset coordinates. Although this algorithm provides a mechanism for imaging angle-dependent reflectivity via shot-profile migration, for sparse-shot geometries the fundamental problem of shot-aliasing may severely impact the quality of CIP gathers.
Confirmation from choline acetylase analyses of a massive cholinergic innervation to the rat hippocampus (1967)

1. Unilateral lesions were made in the fimbria of adult rats with a stereotaxically-applied, radio-frequency current. After 3-23 days survival, fresh, unfixed, transverse sections were cut of the forebrain. Half the sections were stained histochemically to show the distribution of acetylcholinesterase (AChE) activity. From the other sections, small, anatomically defined areas were dissected out and assayed for choline acetylase (ChAc) activity (acetyl-CoA: choline-O-acetyltransferase EC2.3.1.6).2. In the fimbria, anterior to the lesion, ChAc activity rises sharply and is still approximately twice the normal after 7 days. In the hippocampus, ChAc activity falls: in most experiments activity on the operated side was 20-40% of that on the control side, but in some experiments values below 10% were obtained. These changes closely parallel those observed in the staining for AChE.3. The results go far towards proving that the hippocampus receives a massive cholinergic innervation via the fimbria. The fibres concerned appear to be those which stain characteristically for AChE and it seems likely that other pathways showing the same histochemical behaviour are also cholinergic.
Serotonin and Melatonin Do Not Play a Prominent Role in the Growth of Prostate Cancer Cell Lines (2010)

Serotonin receptor antagonists and agonists as well as MLT influence viability and apoptosis of PCa cell lines at supraphysiologic concentrations. In contrast to other reports, our results do not support a regulatory role of serotonin or MLT receptor activation or inhibition in PCa growth.
Preparation and characterization of herbal creams for improvement of skin viscoelastic properties (2008)

The aim of this study was to formulate and evaluate herbal cosmetic creams for their improvement of skin viscoelastic and hydration properties. The cosmetic cream formulations were designed by using ethanolic extracts of Glycyrriza glabra, Curcuma longa (roots), seeds of Psorolea corlifolia, Cassia tora, Areca catechu, Punica granatum, fruits of Embelica officinale, leaves of Centella asiatica, dried bark of Cinnamon zeylanicum and fresh gel of Aloe vera in varied concentrations (0.12-0.9%w/w) and characterized using physicochemical and physiological measurements. The ethanolic extracts of herbs were incorporated in a cream base that is prepared by a phase inversion emulsification technique. The cream base was prepared by utilizing oil of Prunus amagdalus, Sesamum indicum, honey, cetyl alcohol, stearic acid, polysorbate monoleate, sorbitan monostearate, propylene glycol and glycerin. Physicochemical assessments and microbiological testing were completed for all formulations according to the methods of the Indian Standard Bureau. The studies were carried out for 6 weeks on normal subjects (6 males and 12 females, between 22 and 50 years) on the back of their volar forearm for evaluation of viscoelastic properties in terms of extensibility via a suction measurement, firmness using laboratory fabricated instruments such as ball bouncing and skin hydration using electric (resistance) measurement methods. The physicochemical parameters of formulations CAA1-CAA6, i.e. pH, acid value, saponification value, viscosity, spreadability, layer thickness microbial count and skin sensitivity were found to be in the range of 5.01 +/- 0.4-6.07 +/- 0.6, 3.3-5.1 +/- 0.2, 20-32, 5900-6755 cps, 60-99%, 25-50 mum, 31-46 colony-forming units (CFU) and a 0-1 erythema score. The formulations, CAA4 and CAA5, showed an increase in percentage extensibility (32.27 +/- 1.7% and 29.89 +/- 1.64%, respectively), firmness (28.86 +/- 0.86% and 29.89 +/- 2.8%, respectively) and improved skin hydration (15.97 +/- 0.55 and 18.27 +/- 0.99%, respectively) and were found more effective compared with the control product (C7) after the 6- week study.
Geometric aspects of composite pulses (2012)

Unitary operations acting on a quantum system must be robust against systematic errors in control parameters for reliable quantum computing. Composite pulse technique in nuclear magnetic resonance realizes such a robust operation by employing a sequence of possibly poor-quality pulses. In this study, we demonstrate that two kinds of composite pulses-one compensates for a pulse length error in a one-qubit system and the other compensates for a J-coupling error in a two-qubit system-have a vanishing dynamical phase and thereby can be seen as geometric quantum gates, which implement unitary gates by the holonomy associated with dynamics of cyclic vectors defined in the text.
ASSESSMENT OF THE COMMON CARRIER SHIPPING ENVIRONMENT (1979)

An assessment of available data and information describing the common carrier shipping environment was conducted. The assessment included the major shipping hazards of shock, vibration, impact, temperature, and humidity associated with the handling, transportation, and warehousing operations of typical distribution cycles. Previous environmental studies and current data are reviewed and assessed for applicability to general type cargo design and/or evaluation. The data for each hazard are summarized in a format considered most useful to packaging engineers when such data are available. Hazards requiring further information and description are identified and discussed. (Author)
Sound source localization based on zero-crosing peak-amplitude coding (2004)

This paper presents a new method of sound source localization based on zero-crossings generated from binaural filter-bank outputs. To detect the sound source direction, in the conventional methods the inter-aural time differences (ITDs) and the inter-aural intensity differences (IIDs) are estimated using the cross-correlations of neuronal firing rates. However, these methods require high computational complexity involved in the computation of cross-correlations and they suffer from inaccuracies in estimating the ITDs and IIDs, especially in a noisy multisource environment. In this context, we propose a method using zero-crossing and peak-amplitudes (ZCPAs) of binaural filter-bank outputs for accurate and efficient estimation of ITDs and IIDs. The proposed method is able to provide accurate estimation of the sound source direction and robustness to noise while offering significantly less computational complexity compared to cross-correlation based methods.
Characteristics and modeling of high voltage photoconductive switching devices (1986)

Mitochondrial DNA (mtDNA) has been proposed to be involved in carcinogenesis because of its high susceptibility to oxidative DNA damage and limited repair mechanisms. For investigation of the potential role of somatic mtDNA mutations in the tumorigenesis of oral cancer, we screened the occurrence of mtDNA mutations by the temporal temperature gradient gel electrophoresis method. We amplified the entire mitochondrial genome by use of 32 pairs of overlapping primers, and to identify the mutations, we sequenced DNA fragments showing different banding patterns between normal and tumor mtDNA. Fourteen of eighteen (77.8%) oral carcinomas displayed somatic mtDNA mutations, with a total of 26 mutations. Among them, six were in the mRNA coding region. Three were missense mutations (C14F, H186R, T173P) in NADH dehydrogenase subunit 2, and one was a frameshift mutation, 9485delC, in cytochrome c oxidase subunit III. Eight (44%) tumors had insertion or deletion mutations in the nucleotide position 303-309 poly C region of the D-loop. Multiple large deletions were also observed. Our results demonstrate that somatic mtDNA mutations occur in oral cancer. Some missense and frameshift mutations may play an important role in the tumorigenesis of this carcinoma. More extensive biochemical and molecular studies will be necessary for determining the pathologic effect of these somatic mutations.