gebhart/patrepeval huggingface dataset:
Antigenic Expression of B-Cell Chronic Lymphocytic Leukemic Cell Lines (1992)

A flow cytometric analysis of five B cell chronic lymphocytic leukemic (B-CLL) cell lines was undertaken using 129 unknown reagents from the blind panel (BP) and 72 reagents from the known CD panel obtained from the Fourth International Leucocyte Differentiation Conference and Workshop, B cell section (Vienna, 1989). The five cell lines examined were: SeD (PNAS 75, 5706, 1978), B-CLL-LCL (BLOOD 71, 9, 1988), JVM-HH and JVM-2(INT J CAN 38, 531, 1986), and WR#1 (TH and BD). The reagents were #1-129 (blinded panel) and reagents 1-44 and 53-84 (CD panel with CD23 reagents missing). Positivity was defined as greater than 30% of the cells having a three fold increase or more in mean channel fluorescence. Fourty-three reagents of the blinded panel were negative by these criteria while all remaining reagents were positive on all five lines. SeD showed the lowest reactivity; B-CLL-LCL and JVM-2 showed the most reactivity; JVM-HH and WR#1 were intermediate. The known CD panel confirmed the reactivity of the blinded panel. An average immunophenotype was constructed and compared to published normal EBV lymphoblastoid cell lines and several differences were noted. There was an absence or significant decrease in the expression of CD19, CD21, CD22 and CD37 while there was an increased expression of CD38, CD54, CD74 and CD76. The heterogeneity observed between the B-CLL lines may in part be due to polymorphisms but is more likely to represent the underlying heterogeneity seen in common and familial B-CLL.2+öff
Treatment of Ebola Hemorrhagic Fever with Blood Transfusions from Convalescent Patients (1999)

Between 6 and 22 June 1995, 8 patients in Kikwit, Democratic Republic of the Congo, who met the case definition used in Kikwit for Ebola (EBO) hemorrhagic fever, were transfused with blood donated by 5 convalescent patients. The donated blood contained IgG EBO antibodies but no EBO antigen. EBO antigens were detected in all the transfusion recipients just before transfusion. The 8 transfused patients had clinical symptoms similar to those of other EBO patients seen during the epidemic. All were seriously ill with severe asthenia, 4 presented with hemorrhagic manifestations, and 2 became comatose as their disease progressed. Only 1 transfused patient (12.5%) died; this number is significantly lower than the overall case fatality rate (80%) for the EBO epidemic in Kikwit and than the rates for other EBO epidemics. The reason for this low fatality rate remains to be explained. The transfused patients did receive better care than those in the initial phase of the epidemic. Plans should be made to prepare for a more thorough evaluation of passive immune therapy during a new EBO outbreak.
Conformational equilibria in the gamma chain COOH terminus of human fibrinogen. (1987)

The conformations of the gamma chain COOH terminus of intact fibrinogen and various fragments containing this region have been compared by an immunochemical analysis. Location of a major epitope in the sequence gamma 391-405 was successfully predicted from a hydrophobicity profile. An antibody population specific for the native epitope within the gamma 391-405 segment was isolated by immunoadsorption. Between 19.2 and 22.8% of antibodies were obtained from three different antisera, indicating that this region represents one of the major epitopes of native fibrinogen. Anti-gamma 391-405(N) antibodies were used to determine the value of Kconf, the equilibrium constant for the interconversion of the non-native and native conformations of this epitope. The measurements were done using native fibrinogen, fragments D1 and DD, gamma chain, and gamma 391-405. In addition, the effect of 5 M guanidine HCl on the conformation of fragments D1 and DD, which is known to abolish their antipolymerizing activity, was studied. Radioiodinated fibrinogen was used in the determination of Kconf, CI50%, and CIs (quantitative analytical parameters calculated from competitive inhibition radioimmunoassays) by measuring the competition between 125I-fibrinogen and the fibrinogen derivatives under study for binding to the immunochemically purified antibody. The measurements indicated that the epitope is unperturbed by iodination of fibrinogen and that 38.5% of fragment D1, 8.9% of fragment DD, 3.6% of the gamma chain, and less than 0.008% of the gamma 391-405 molecules adopt in aqueous solution the native conformation within the epitope. Denaturation of fragment D1 with 5 M guanidine HCl affected only slightly the conformation of this gamma chain determinant. More significant changes in the conformation were observed when fragment DD was denatured. The results suggest that long-range interactions are necessary for the stabilization of the native structure in the region of fibrinogen that interacts with the antibody and which is in close vicinity to the polymerization site, cross-linking site, and platelet recognition site.
Signal separation by symmetric adaptive decorrelation: stability, convergence, and uniqueness (1995)

The performance of signal enhancement systems based on adaptive filtering is highly dependent on the quality of the noise reference. In the LMS algorithm, signal leakage into the noise reference leads to signal distortion and poor noise cancellation. The origin of the problem lies in the fact that LMS decorrelates the signal estimate with the noise reference, which, in the case of signal leakage, makes little sense. An algorithm is proposed that decorrelates the signal estimate with a "signal-free" noise estimate, obtained by adding a symmetric filter to the classical structure. The symmetric adaptive decorrelation (SAD) algorithm no longer makes a distinction between signal and noise and is therefore a signal separator rather than a noise canceler. Stability and convergence are of the utmost importance in adaptive algorithms and hence are carefully studied. Apart from limitations on the adaptation constants, stability around the desired solution can only be guaranteed for a subclass of signal mixtures. Furthermore, the decorrelation criterion does not yield a unique solution, and expressions for the "phantom" solutions are derived. Simulations with short FIR filters confirm the predicted behavior.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Demonstration of a splitter/router based on a chirped waveguide grating router (1998)

We propose and demonstrate a novel method to build a device that acts like an optical multiplexer in one wavelength band and an optical power splitter in another one. The method is based on a chirped waveguide grating router design. There is no penalty in terms of insertion loss or crosstalk for the routing characteristics of the device but there is a tradeoff between the splitter bandwidth and the splitter excess loss. The simulated and experimental results are in good qualitative agreement.
Picosecond Electronics and Optoelectronics: Proceedings of the Topical Meeting Held in Lake Tahoe, Nevada on 13-15 March 1985, (1985)

Contents: Ultrafast Optics and Electronics, High-Speed Phenomena in Bulk Semiconductors, Quantum Structures and Applications, Picosecond Diode Lasers, Optoelectronics and Photoconductive Switching, and Cryoelectronics.
Algorithms for maximum satisfiability using unsatisfiable cores (2008)

Many decision and optimization problems in electronic design automation (EDA) can be solved with Boolean satisfiability (SAT). Moreover, well-known extensions of SAT also find application in EDA, including pseudo-Boolean optimization, quantified Boolean formulas, multi-valued SAT and, more recently, Maximum Satisfiability (MaxSAT). Algorithms for MaxSAT are still fairly inefficient in industrial settings, in part because the most effective SAT techniques cannot be easily extended to MaxSAT. This paper proposes a novel algorithm for MaxSAT that improves existing state of the art solvers by orders of magnitude on industrial benchmarks. The new algorithm exploits modern SAT solvers, being based on the identification of unsatisfiable subformulas. Moreover, the new algorithm provides additional insights between unsatisfiable subformulas and the maximum satisfiability problem.
Contextual Inference in Contour-Based Stereo Correspondence (2006)

Standard approaches to stereo correspondence have difficulty when scene structure does not lie in or near the frontal parallel plane, in part because an orientation disparity as well as a positional disparity is introduced. We propose a correspondence algorithm based on differential geometry, that takes explicit advantage of both disparities. The algorithm relates the 2D differential structure (position, tangent, and curvature) of curves in the left and right images to the Frenet approximation of the (3D) space curve. A compatibility function is defined via transport of the Frenet frames, and they are matched by relaxing this compatibility function on overlapping neighborhoods along the curve. The remaining false matches are concurrently eliminated by a model of &quot;near&quot; and &quot;far&quot; neurons derived from neurobiology. Examples on scenes with complex 3D structures are provided.
A Ras-Dependent Pathway Regulates RNA Polymerase II Phosphorylation in Cardiac Myocytes: Implications for Cardiac Hypertrophy (1998)

Despite extensive evidence implicating Ras in cardiac muscle hypertrophy, the mechanisms involved are unclear. We previously reported that Ras, through an effector-like function of Ras GTPase-activating protein (GAP) in neonatal cardiac myocytes (M. Abdellatif et al., J. Biol. Chem. 269:15423-15426, 1994; M. Abdellatif and M. D. Schneider, J. Biol. Chem. 272:527-533, 1997), can up-regulate expression from a comprehensive set of promoters, including both cardiac cell-specific and constitutive ones. To investigate the mechanism(s) underlying these earlier findings, we have used recombinant adenoviruses harboring a dominant negative Ras (17N Ras) allele or the N-terminal domain of GAP (nGAP), responsible for the Ras-like effector function. Inhibition of endogenous Ras reduced basal levels of [3H]uridine and [3H]phenylalanine incorporation into total RNA, mRNA, and protein, with parallel changes in apparent cell size. In addition, 17N Ras markedly inhibited phosphorylation of the C-terminal domain (CTD) of RNA polymerase II (pol II), known to regulate transcript elongation, accompanied by down-regulation of its principal kinase, cyclin-dependent kinase 7 (Cdk7). In contrast, nGAP elicited the opposite effects on each of these parameters. Furthermore, cotransfection of constitutively active Ras (12R Ras) with wild-type pol II, rather than a truncated mutant lacking the CTD, demonstrated that Ras activation of transcription was dependent on the pol II CTD. Consistent with a potential role for this pathway in the development of cardiac myocyte hypertrophy, alpha1-adrenergic stimulation similarly enhanced pol II phosphorylation and Cdk7 expression, where both effects were inhibited by dominant negative Ras, while pressure overload hypertrophy led to an increase in both hyperphosphorylated and hypophosphorylated pol II in addition to Cdk7.
The Rule Set Based Access Control (RSBAC) Framework for Linux (2001)

RSBAC (“Rule Set Based Access Control”) is an open source security extension for Linux kernels based on the Generalized Framework for Access Control (GFAC). It is a kernel-based access control scheme, which can be configured with a set of security policies chosen from a provided set of options and which can be used to significantly enhance Linux system security. In this paper, we present the RSBAC system architecture, the RSBAC security policy components and outline the RSBAC implementation. Besides, we briefly compare RSBAC with other Linux kernel-based access control projects.
Structure-Based Discovery of BM-957 as a Potent Small-Molecule Inhibitor of Bcl-2 and Bcl-xL Capable of Achieving Complete Tumor Regression (2012)

Bcl-2 and Bcl-xL antiapoptotic proteins are attractive cancer therapeutic targets. We have previously reported the design of 4,5-diphenyl-1H-pyrrole-3-carboxylic acids as a class of potent Bcl-2/Bcl-xL inhibitors. In the present study, we report our structure-based optimization for this class of compounds based upon the crystal structure of Bcl-xL complexed with a potent lead compound. Our efforts accumulated into the design of compound 30 (BM-957), which binds to Bcl-2 and Bcl-xL with K(i) < 1 nM and has low nanomolar IC(50) values in cell growth inhibition in cancer cell lines. Significantly, compound 30 achieves rapid, complete, and durable tumor regression in the H146 small-cell lung cancer xenograft model at a well-tolerated dose schedule.
Why we needed a new health consumer peak body in NSW (2011)

Health Consumers NSW (HCNSW) is the new, independent peak health consumer organisation in our state, providing the voice of health consumers in shaping policy and services.
Study of &beta;-lactamase tem1 synthesis in various escherichia coli strains infected by the phage &lambda; bla with amber-mutations in different regulatory genes (1991)

. . , . . - TEM1 ESCHERICHIA COLI bla - *
Intrusion prevention system of automotive network CAN bus (2016)

Automotive networks based on the Controller Area Network (CAN) bus (ISO 11898) family of protocols have been shown to be vulnerable to exploits by hackers who are outside the vehicle. These networks can be compromised in a manner which could jeopardize vehicle occupants. One well-publicized exploit led to a costly automotive recall that affected more than a million vehicles. Other exploits can allow criminals to steal cars without physically breaking into them. While no fatalities have yet occurred, hackers could trigger an event that led to accident involving serious injury or even death. The CAN bus connects electronic control units (ECUs), some of which are required for safety and emissions systems such as the anti-lock braking and fuel injection systems. In addition to controlling required functions, other ECUs provide consumer-oriented features such as infotainment and lighting. Whether factory installed or aftermarket add-ons, each ECU introduces attack vectors into the overall automotive network. This research focuses on securing these vehicle networks, specifically the CAN bus. This paper will analyze the current vulnerabilities and describe our design for a real-time intrusion prevention system (IPS) that neutralizes attacks by actively monitoring the CAN bus and eliminating malicious messages.
Carbodiimide--sulfoxide reactions. IX. Synthesis of 2'- and 3'-keto derivatives of cytidine (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCarbodiimide--sulfoxide reactions. IX. Synthesis of 2'- and 3'-keto derivatives of cytidineU. Brodbeck and J. G. MoffattCite this: J. Org. Chem. 1970, 35, 10, 3552–3558Publication Date (Print):October 1, 1970Publication History Published online1 May 2002Published inissue 1 October 1970https://doi.org/10.1021/jo00835a081RIGHTS & PERMISSIONSArticle Views212Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alerts Get e-Alerts
Laboratory‐simulated acid‐sulfate weathering of basaltic materials: Implications for formation of sulfates at Meridiani Planum and Gusev crater, Mars (2005)

Acid‐sulfate weathering of basaltic materials is a candidate formation process for the sulfate‐rich outcrops and rocks at the MER rover Opportunity and Spirit landing sites. To determine the style of acid‐sulfate weathering on Mars, we weathered basaltic materials (olivine‐rich glassy basaltic sand and plagioclase feldspar‐rich basaltic tephra) in the laboratory under different oxidative, acid‐sulfate conditions and characterized the alteration products. We investigated alteration by (1) sulfuric‐acid vapor (acid fog), (2) three‐step hydrothermal leaching treatment approximating an “open system,” and (3) single‐step hydrothermal batch treatment approximating a “closed system.” In acid fog experiments, Al‐, Fe‐, and Ca‐sulfates and amorphous silica formed from plagioclase‐rich tephra, and Mg‐ and Ca‐sulfates and amorphous silica formed from the olivine‐rich sands. In three‐step leaching experiments, only amorphous Si formed from the plagioclase‐rich basaltic tephra, and jarosite, Mg‐, and Ca‐sulfates and amorphous silica formed from olivine‐rich basaltic sand. Amorphous silica formed under single‐step experiments for both starting materials. On the basis of our experiments, jarosite formation in Meridiani outcrop is potential evidence for an open system acid‐sulfate weathering regime. Waters rich in sulfuric acid percolated through basaltic sediment, dissolving basaltic phases (e.g., olivine) and forming jarosite, other sulfates, and iron oxides. Aqueous alteration of outcrops and rocks on the West Spur of the Columbia Hills may have occurred when vapors rich in SO 2 from volcanic sources reacted with basaltic materials. Soluble ions from the host rock (e.g., olivine) reacted with S to form Ca‐, Mg‐, and other sulfates along with iron oxides and oxyhydroxides.
Routing virtual circuits with timing requirements in virtual path based ATM networks (2002)

Real-time communication with performance guarantees is expected to become an important feature of future computer networks. Given an ATM network topology, its virtual path (VP) layout, and its traffic demands, we consider in this paper the problem of selecting for each virtual circuit (VC) with timing requirements a route (i.e., a sequence of VPs) along which sufficient resources are available to meet the user-specified end-to-end delay requirements. Our objective is to (i) provide the timing guarantee for the VC, while not jeopardizing the QoS guarantees to other existing VCs. We adopt the real-time channel model to characterize the traffic characteristics and the timing requirements of a VC. We then propose a distributed VC routing scheme based on the distributed Bellman-Ford algorithm to identify an "appropriate" route through the network. By "appropriate", we mean that the route traverses a minimum number of VPs among all possible routes that have sufficient resources over to fulfill the end-to-end timing requirement of the VC. To ensure that there are sufficient bandwidths over all the VPs along the selected route, we incorporate in our proposed scheme a priority assignment method to calculate the minimum worst-case traversal time which messages of a VC will experience on a VP along which the VC is routed. We also comment on the performance of, and the message overhead incurred in the proposed scheme.
Event-triggered optimal control of nonlinear continuous-time systems in affine form by using neural networks (2014)

The proposed event-triggered control design uses the adaptive dynamic programming (ADP) technique to solve the infinite-horizon optimal control of nonlinear continuous time system in affine form with complete unknown system dynamics in a forward time and online manner. The approximation property of the neural network (NN) is used to estimate the system dynamics and the value function with event-based sampling of state vector. Subsequently the estimated values are used to design the near optimal control policy. In addition, the NN weights are updated as a jump at every trigger instant, hence aperiodic in nature, to save computation when compared to the traditional NN-based approaches. Further, the closed-loop dynamics are formulated as a nonlinear impulsive dynamical system and the extension of the Lyapunov technique is utilized to prove the locally ultimate boundedness of all the closed-loop signals by deriving an adaptive event-trigger condition. Nonetheless, a positive lower bound on the inter-event time is guaranteed to avoid accumulation point. Finally, the analytical design is evaluated by using an example.
Cloning and nucleotide sequence of <i>frpC</i>, a second gene from <i>Neisseria meningitidis</i> encoding a protein similar to RTX cytotoxins (1993)

Neisseria meningitidis FAM20 has recently been shown to produce two Fe-regulated proteins (FrpA and FrpC) related to the RTX family of cytotoxins. Here we report the cloning and DNA sequence of the locus containing the gene encoding the larger meningococcal RTX protein FrpC. FrpC was highly similar to FrpA throughout much of the predicted protein, with two main differences. Whereas the FrpA protein had 13 copies of the nine-amino-acid repeat units typical of RTX proteins, FrpC had 43 copies. The additional copies in FrpC apparently arose from a threefold tandem amplification of a 600bp DNA fragment encoding the repeats. In addition, the frpC gene lacked good promoter consensus sequences. An open reading frame (ORF1) of unknown function was found immediately upstream of frpC, suggesting the possibility that frpC was cotranscribed with ORF1. A probable promoter was found 300bp upstream of ORF1, and it contained a Fur protein-binding sequence found in the promoters of Fe-regulated Escherichia coli genes. DNA upstream of the ORF1/frpC promoter was homologous to IS1016-like elements surrounding capsulation loci of strains of Haemophilus influenzae. A FrpC-like protein (reactive in immunoblots with monoclonal antibody 9D4; multiple reactive bands of about 200 to 120 kDa) was found in five out of eight meningococcal strains but only in one out of 14 other Neisseria, suggesting that FrpC may participate in the pathogenesis of meningococcal disease.
CPI-1189. Centaur. (2002)

The efficacy of the proapoptotic cytokine tumor necrosis factor (TNF) alpha-inhibiting compound CPI-1189 has been demonstrated in various cell culture and animal models of chronic neurodegenerative and inflammatory diseases. CPI-1189 intracellularly inhibits the p38 mitogen-activated protein kinase phosphoactivation, thereby protecting against TNF alpha-induced neurodegeneration. Clinical proof-of-concept phase IIa trials in patients with Parkinson's disease and AIDS dementia complex were successful. These studies demonstrated clinical relevance for treatment with CPI-1189 (50 to 100 mg/day), which attenuated the deterioration in cognitive and/or motor function without any relevant side effects. Since the importance of neuroprotection is emerging, in particular in neurodegenerative diseases with concomitant observed immunological pro-apoptotic alterations in the central nervous system, long-term application of CPI-1189 could represent a promising future therapeutic alternative, in addition to neuroprotective compounds such as selegiline.
Intranasal Mupirocin to Prevent Postoperative<i>Staphylococcus aureus</i>Infections (2002)

Prophylactic intranasal application of mupirocin did not significantly reduce the rate of S. aureus surgical-site infections overall, but it did significantly decrease the rate of all nosocomial S. aureus infections among the patients who were S. aureus carriers.