gebhart/patrepeval huggingface dataset:
Prevention and treatment of anastomotic fistula of esophagus cancer and cardiac cancer (2006)

Objective:To study the generative factors of anastomotic fistula after esophagus cancer and cardiac cancer operation and its prevention and treatment.Methods:After excising the turnors,the esophagogastrostomy was performed in 279 cases aged 37 to 78 years,in which the intrathoracic anastomose was adopte in 208 cases and cervial anastomose in 71 cases.Results:Four of 8 patients with anastomotic fistula in the intrathoracic anastomse died,while none of 10 cases in the cervial anastomose died.Conclusion:Careful procedure and improving the anastomotic method are the key factors to reduce the anastomotic fistula,the accurate control of infection and full nutritive support are the effective methods to decrease the mortality rate of this disease.
Stem cell therapy in inflammatory bowel disease: A promising therapeutic strategy? (2015)

Inflammatory bowel diseases are inflammatory, chronic and progressive diseases of the intestinal tract for which no curative treatment is available. Research in other fields with stem cells of different sources and with immunoregulatory cells (regulatory T-lymphocytes and dendritic T-cells) opens up new expectations for their use in these diseases. The goal for stem cell-based therapy is to provide a permanent cure. To achieve this, it will be necessary to obtain a cellular product, original or genetically modified, that has a high migration capacity and homes into the intestine, has high survival after transplantation, regulates the immune reaction while not being visible to the patient's immune system, and repairs the injured tissue.
Geometrically Controlled Selective Formation of Nitrido Technetium(V) Asymmetrical Heterocomplexes with Bidentate Ligands (2000)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTGeometrically Controlled Selective Formation of Nitrido Technetium(V) Asymmetrical Heterocomplexes with Bidentate LigandsCristina Bolzati, Alessandra Boschi, Adriano Duatti, Sushumna Prakash, Licia Uccelli, Fiorenzo Refosco, Francesco Tisato, and Giuliano BandoliView Author Information Laboratory of Nuclear Medicine Department of Clinical & Experimental Medicine University of Ferrara, Via L. Borsari, 46, 44100 Ferrara, Italy ICTIMA, CNR, Corso Stati Uniti, 4, 35020 Padova, Italy Department of Pharmaceutical Sciences University of Padova, Via Marzolo, 6, 35131 Padova, Italy Cite this: J. Am. Chem. Soc. 2000, 122, 18, 4510–4511Publication Date (Web):April 25, 2000Publication History Received28 October 1999Published online25 April 2000Published inissue 1 May 2000https://pubs.acs.org/doi/10.1021/ja993834uhttps://doi.org/10.1021/ja993834urapid-communicationACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views308Altmetric-Citations54LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information SUBJECTS:Ligands,Mathematical methods,Molecular structure,Nuclear medicine,Phosphorus Get e-Alerts
Machine Learning Prediction Based CSI Acquisition for FDD Massive MIMO Downlink (2018)

In this paper, we propose a simple and efficient approach to reduce the overhead of downlink channel estimation and feedback using linear regression (LR) and support vector regression (SVR) in machine learning. Specifically, we divide the indexes of the antennas at the base station (BS) into two sets. We first use some well estimated channel samples to train a regression model, where the channel state information (CSI) corresponding to one set is used as input while the other is output. In the online channel estimation phase, only the CSI of the antennas in one set needs to be estimated and the CSI of the antennas in the other set can be predicted by inputting the estimated CSI into the trained regression model. Numerical results show the proposed approach can reduce the overhead of both downlink pilot and uplink feedback considerably and thus can improve the downlink achievable rate significantly compared with the existing schemes.
Return to Duty After Type III Open Tibia Fracture (2011)

Despite the severe nature of combat extremity wounds, 20% of patients with salvaged Type III open tibia fractures and 22% with isolated injuries were able to return to active duty. These rates are similar to those reported for civilian amputees. Amputees in our cohort were less likely to RTD.
Folding algorithms and mechanisms synthesis for robotic ironing (2004)

Automating domestic ironing is a challenge to the robotic community, particularly in terms of modelling and advanced mechanism design. This paper investigates the ironing process, its relevant folding algorithms and analysis techniques, presents the advanced mechanism synthesis and introduces cross‐disciplinary research. It summarises the second part of the results of a technology study carried out under an EPSRC grant “A Feasibility Study into Robotic Ironing”, and proposes new techniques in developing a folding and unfolding algorithm and in developing a task‐oriented mechanism synthesis for robotic ironing.
Use of FT-IR Internal Reflection Spectroscopy in Combinatorial Chemistry (1996)

Combinatorial chemistry technologies for new-lead discovery and lead optimization have recently captured the imagination of the drug-discovery community. With the use of solid-phase synthesis on polymer substrates, vast numbers of molecules, so-called chemical libraries, will be readily accessible by these combinatorial approaches as potential sources of new leads for drug discovery.
Identification of a new membrane-bound heparan sulphate proteoglycan (1995)

The morphological changes that occur during intestinal development have been extensively described, but the molecular basis of these changes is largely unknown. As a result of our efforts to identify molecules that play a role in intestinal morphogenesis during development, we have previously isolated a cDNA that is developmentally regulated in the intestine. This cDNA, named OCI-5, was recently shown to have 20-25% identity at the protein-sequence level with glypican and cerebroglycan, two heparan sulphate proteoglycans (HSPG) that are attached to the cell membrane by a glycosyl-phosphatidylinositol (GPI) anchor. Here we provide experimental evidence indicating that OCI-5 is also a GPI-linked HSPG. We demonstrate this by showing that OCI-5 can be labelled with radioactive sulphate and can be digested by heparitinase, but not by chondroitinase. We also show that treatment with phosphatidylinositol-specific phospholipase C releases OCI-5 from the cell surface of COS cells transfected with an OCI-5 expression vector. The identification of OCI-5 as a GPI-linked HSPG confirms that this proteoglycan belongs to the same family of HSPGs that include glypican and cerebroglycan.
Home hemodialysis: Infrastructure, water, and machines in the home (2015)

We describe the infrastructure that is necessary for hemodialysis in the home focusing on physical requirements, the organization of plumbing and water, and the key features that should guide the selection of machines that are suitable for home use.
Gross alpha and gross beta radioactivity measurements in groundwater from Nasarawa North district Nasarawa state Nigeria (2021)

Gross alpha and gross beta radioactivity in 40 groundwater (borehole and well water) samples from Akwanga, Wamba and N/Eggon Areas of Nasarawa North District, Nasarawa State Nigeria was measured using the low background MPC2000B DP model Gross Alpha/Beta counter (ORTEC ® -Protean Instrument Corporation). The values of gross alpha activity in this study were observed to be less than those of gross beta activity. The average activity values of gross alpha and gross beta obtained were 0.25 ± 0.04 Bq/L and 2.23 ± 0.09 Bq/L for Akwanga, 0.19 ± 0.03 Bq/L and 1.62 ± 0.08 Bq/L for Wamba and 0.30 ± 0.05 Bq/L and 3.00 ± 0.14 Bq/L for N/Eggon areas, respectively. The results are found to be below the World Health Organization guideline levels for drinking water quality of 0.5 Bq/L for gross alpha but 45% of the samples slightly exceeded the 1.0 Bq/L for gross beta. This implied that the groundwater in the study area is radiologically safe for consumption and may not pose any significant health hazards to humans by way of ingestion. The groundwater from the study area is also safe for drinking as the total dissolved solids average values were below the contamination limit for palatable drinking water guideline level of 1000 mg/L. However, a radionuclide-specific test and a regular monitoring program of the environment are hereby suggested.
Why cross-platform security (2003)

Heterogeneity is a given these days in almost any IT system installation. It presents problems for implementing security requirements. The first step is to find common ground among the diverse systems. The article discusses how to do this at the various different levels, with security as the objective.
VEGFR-3, VEGF-C and VEGF-D mRNA quantification by RT-PCR in different human cell types. (2006)

The molecular events favoring lymphangiogenic pathways for tumor growth and dissemination are not perfectly understood, nor are the expression patterns of lymphangiogenic biomarkers such as the VEGFR-3 receptor and its ligands, VEGF-C and VEGF-D. In particular, VEGFR-3 expression is not restricted to the lymphatic endothelium, but is found on some cancer cells and other cell types. A quantitative RT-PCR method was set up to measure the mRNA levels of VEGFR-3, VEGF-C and VEGF-D. With this method, a very low detection threshold was obtained when tested on 17 different human cell types. It was found that, in contrast to VEGF-D mRNA, the VEGFR-3 and VEGF-C mRNAs were not expressed in all the cell types studied, and that blood cells expressed high VEGFR-3 mRNA levels compared to solid tumor cells. As a result, quantitative RT-PCR is considered to be a highly reliable and reproducible technique that could help elucidate lymphangiogenic marker patterns of expression and function in cancer.
Detailed nomenclature for dendritic molecules (2005)

A systematical and detailed nomenclature for dendritic species (“cascadane-nomenclature”) is developed which is based on the rules of naming dendrimers introduced by G. R. Newkome in 1993. As the importance and versatility of dendritic species in organic chemistry is increasing, it is to distinguish between different dendritic architectures such as dendrons and dendrimers. We attach importance to the swift conveyance of the molecular architecture and its building units by such name-fragments as expressions in brackets, characteristic exponents and indices, as in previously successful naming methods for such molecular structure-classes as polycycles, phanes, crown compounds, podands and mechanically linked molecules, e.g. catenanes. Furthermore, the new modular nomenclature incorporates as many analogies to the IUPAC-nomenclature as possible.
ChemInform Abstract: BARBITURIC ACID DERIVATIVES (1982)

Abstract Die hergestellten Barbitursäure‐Derivate (VI) zeigten keine bactericide Wirkung gegen Bacillus subtilis, die Acetylbarbitursäure (V) und die Arylthiosemicarbazide (IV) sind stark aktiv.
<title>Long-period fiber gratings: sensors, sources, and beyond</title> (1999)

Long period fiber grating devices are finding a broad range of applications as wavelength selective filters and spectrally selective sensors. In this paper I describe the theory and fabrication of long period fiber gratings, including mask considerations for UV fabrication, and give an overview of applications. Two applications are described in detail: an embeddable point sensor for strain and temperature in a structure, and an all-fiber, coupler-free Mach-Zehnder interferometer for WDM filtering applications.
DIURNAL CORTISOL VARIATIONS AND SYMPTOMS IN PATIENTS WITH INTERSTITIAL CYSTITIS (2002)

These findings imply that regulation of the hypothalamic-pituitary-adrenal axis may be associated with interstitial cystitis symptomatology and there may be different diurnal hypothalamic-pituitary-adrenal patterns in patients with interstitial cystitis who do and do not have co-morbid conditions. These findings may have treatment implications for patients with interstitial cystitis who have early morning cortisol deficiencies.
A Configurable Asynchronous Pseudorandom Bit Sequence Generator (2007)

We present a method of building pseudorandom bit sequence (PRBS) generators using coupled asynchronous FIFO rings. A traditional PRBS generator using a linear feedback shift register (LFSR) can only generate a single maximal-length pattern with a fixed period. Our proposed FIFO implementation allows a single circuit to produce many different patterns of different periods, all of which are maximal-length, based on the initialization of the circuit. It also provides intrinsic fine-grain pipelining which alleviates the large feedback logic overhead in configurations with many taps, making such implementations practical. With an asynchronous-to-clocked interface, one can use the circuit in a synchronous environment. Detailed simulation results are presented.
Bromination stabilizes poly(dG-dC) in the Z-DNA form under low-salt conditions (1984)

Using circular dichroism studies, Pohl & Jovin (1972) [Pohl, F.M., & Jovin, T.M. (1972) J. Mol. Biol. 67, 375-396] demonstrated that poly(dG-dC) undergoes a salt-dependent conformational change characterized by a spectral inversion. The low-salt form corresponds to the right-handed B form of DNA and the high-salt form to the left-handed Z-DNA helix. Modification of poly(dG-dC) by adding bromine atoms to the C8 position of guanine and the C5 position of cytosine residues stabilized this polymer in the Z-DNA form under low-salt conditions. The guanine residues were found to be twice as reactive as the cytosine residues. With a modification of 38% Br8G and 18% Br5C, the polymers formed a stable Z-DNA helix under physiological conditions. The bromination produced spectroscopic features very similar to poly(dG-dC) in 4 M NaCl. However, bromination did not freeze the Z structure as was shown by ethidium bromide intercalation studies. Addition of the dye favored an intercalated B-DNA form. The conversion of B- to Z-DNA leads to profound conformational changes which were also seen by a reduced insensitivity to various exo- and endonucleases. Comparative studies showed that the brominated polymers have a high affinity to nitrocellulose filters. In 1 M NaCl, there was virtually no binding of B-DNA, but a substantial binding of Z-DNA was found even at rather low levels of bromination.(ABSTRACT TRUNCATED AT 250 WORDS)
Epidermal Growth Factor Induces Ubiquitination of Eps15 (1997)

Epidermal growth factor (EGF) receptor pathway substrate clone 15 (Eps15) has been described as a 142-kDa EGF receptor substrate. It has been shown to bind to the EGF receptor, adaptor protein-2, and clathrin and is present at clathrin-coated pits and vesicles. Upon stimulation of cells with EGF or transforming growth factor alpha, Eps15 becomes rapidly and transiently phosphorylated on tyrosine residues. This phosphorylation coincides with an increase of 8 kDa in molecular mass. Here we show that this increase in molecular mass is not due to tyrosine phosphorylation. Instead, we found both by Western blotting and protein sequencing that this EGF-induced increase in molecular mass is the result of monoubiquitination. Eps15 ubiquitination but not tyrosine phosphorylation was inhibited under conditions that blocked EGF-induced internalization of the EGF receptor. Our results establish ubiquitination as a second form of EGF-stimulated covalent modification of Eps15.
Medicine and the Racial Divide (2003)

The role of race in the cause and treatment of disease has been the subject of much discussion during the past year, in the pages of the Journal and elsewhere. Two Sounding Board articles in this issue of the Journal are the most recent contributions to the debate over whether race — defined broadly as the sharing of a common ancestry — should be considered by those who study disease and patients' responses to treatment.As both sets of authors point out, the subject is fraught with sensitivities fueled by past abuses and the potential for future abuses. But whereas . . .
THE FORMATION OF PINOSYLVIN AND ITS MONOMETHYL ETHER IN THE SAPWOOD OF PINUS RESINOSA AIT. (1961)

Mechanical damage to bark and cambium of red pine (Pinus resinosa Ait.), as well as fungal penetration of sapwood in the interior of roots and stems, induces the formation of heartwood substances in the affected parts of the sapwood. Paper chromatography disclosed the occurrence of pinosylvin (trans-3,5-dihydroxy-stilbene) and its monomethyl ether (3-hydroxy-5-methoxy-stilbene) in affected sapwood. Normal undamaged sapwood does not contain these substances, which were found to be restricted to the heartwood, except for pinosylvin monomethyl ether, which was found to occur also in the pith of branches.Field and laboratory experiments were carried out on the local formation of pinosylvins in the sapwood of live branches of red pine following wounding of the cambium. It was found that the pinosylvins are formed in the late part of the growing season and during the dormant season. Cross sections through the wound on branches showed the pinosylvins in a triangular pattern with the wounded cambium as a base line and the other two sides of the triangle extending along the rays to the pith.Cells killed rapidly did not form pinosylvins. However, cells dying slowly, and in the laboratory experiments under the influence of desiccation, produced both pinosylvin and its monomethyl ether. The optimum production of the pinosylvins occurred in the laboratory at approximately 25 °C, while no production was found at 35 °C and higher temperatures.It is concluded that the pinosylvins are formed by living cells in the sapwood under the influence of desiccation and/or aeration and that their formation is a defense reaction against attack by pathogens.The term "protection wood" is preferred as an alternative term for "pathological heartwood" or "mineral stain", which has been used by many authors.
Flow separation control by dielectric barrier discharge plasma actuation via pulsed momentum injection (2018)

Control of a turbulent boundary layer separating on a half-cylinder mounted on a flat plate has been investigated using a Dielectric Barrier Discharge (DBD) plasma actuator placed along the apex of a cylinder. The main focus of the study has been to evaluate if the control ability of the actuator can be improved through pulsed actuation compared to its steady counterpart. Investigations of the electric wind induced by the DBD plasma actuator in still air, when mounted on the flat plate, revealed that while the steady actuation produces an electric wind similar to a wall jet, the pulsed actuation creates a train of co-rotating vortices. The vortices are the result of a starting vortex produced by the actuator at each actuation pulse. A parametric study showed a dependence of the size, shape and propagation velocity of the vortices on the pulse frequency and duty cycle. With the actuator mounted along the apex of the cylinder, Particle Image Velocimetry measurements of the uncontrolled and controlled flow with a free-stream velocity of 5 m/s showed a clear reduction of the recirculation region downstream the cylinder when using plasma actuation. An even higher control effect could be achieved with pulsed actuation compared to the steady actuation. Phase-locked measurements of the unsteady actuation showed that pulsed actuation periodically shifted the flow separation location resulting in the propagation of vortical structures in the recirculation region. The size of the vortical structures showed a dependence on the pulsed actuation timing parameters.
Binding of alpha-bungarotoxin to proteolytic fragments of the alpha subunit of Torpedo acetylcholine receptor analyzed by protein transfer on positively charged membrane filters. (1984)

Proteolytic fragments of the alpha subunit of the acetylcholine receptor retain the ability to bind alpha-bungarotoxin following resolution by polyacrylamide gel electrophoresis and immobilization on protein transfers. The alpha subunit of the acetylcholine receptor of Torpedo electric organ was digested with four proteases: Staphylococcus aureus V-8 protease, papain, bromelain, and proteinase K. The proteolytic fragments resolved on 15% polyacrylamide gels were electrophoretically transferred onto positively charged nylon membrane filters. When incubated with 0.3 nM 125I-labeled alpha-bungarotoxin and autoradiographed, the transfers yielded patterns of labeled bands characteristic for each protease. The molecular masses of the fragments binding toxin ranged from 7 to 34 kDa, with major groupings in the 8-, 18-, and 28-kDa ranges. The apparent affinity of the fragments for alpha-bungarotoxin as determined from the IC50 value was 6.7 X 10(-8) M. The labeling of fragments with alpha-bungarotoxin could be inhibited by prior affinity alkylation of receptor-containing membranes with 4-(N-maleimido)-alpha-benzyltrimethylammonium iodide. These findings demonstrate that immobilized proteolytic fragments as small as 1/5 the size of the alpha subunit retain the structural characteristics necessary for binding alpha-bungarotoxin, although the toxin is bound to the fragments with lower affinity than to the native receptor. The effect of affinity ligand alkylation demonstrates that the alpha-bungarotoxin binding site detected on the proteolytic fragments is the same as the affinity-labeled acetylcholine binding site on the intact acetylcholine receptor.
Protonless NMR Experiments for Sequence-Specific Assignment of Backbone Nuclei in Unfolded Proteins (2006)

Natively unfolded proteins are increasingly recognized to play important physiological roles. These proteins do not crystallize, so NMR is the only technique able to provide structural and dynamic information. However, in unfolded proteins, the proton chemical shift dispersion is poor, causing severe problems in resonance assignment. We designed a novel strategy based on two protonless experiments, a CBCACON-IPAP and a novel COCON-IPAP, that permits a straightforward and unequivocal backbone heteronuclear assignment of the natively unfolded protein alpha-synuclein.
PREPARATION OF (S)-2-ALLYL-2-METHYLCYCLOHEXANONE (2009)

7.26 5.96 5.86 4.57 4.56 2.34 1.66 1.40 1.33 0.0 5.0 10.0 2.00 4.00 4.09 2.01 2.00 2.04 4.07 1 H NMR Spectrum of diallyl pimelate (400 MHz, CDCl 3 )
ChemInform Abstract: Dihydropyrimidine Calcium Channel Blockers. Part 3. 3‐Carbamoyl‐4‐aryl‐1,2,3,4‐tetrahydro‐6‐methyl‐5‐pyrimidinecarboxylic Acid Esters as Orally Effective Antihypertensive Agents. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.