gebhart/patrepeval huggingface dataset:
Late-Onset Ornithine Transcarbamylase Deficiency: Treatment and Outcome of Hyperammonemic Crisis (2014)

Hyperammonemic crises in ornithine transcarbamylase deficiency (OTC) can be associated with devastating cerebral edema resulting in severe long-term neurologic impairment and death. We present an 8-year-old boy who had late-onset OTC deficiency in which early and aggressive management of hyperammonemia and associated cerebral edema, including therapeutic hypothermia and barbiturate-induced coma, resulted in favorable neurologic outcome. Our patient presented with vomiting and altered mental status, and was found to have a significantly elevated serum ammonia level of 1561 μmol/L. Hyperammonemia was managed with hemodialysis, 10% sodium phenylacetate, 10% sodium benzoate, L-arginine, intravenous 10% dextrose, intralipids, and protein restriction. He developed significant cerebral edema with intracranial pressures >20 mm Hg, requiring treatment with 3% saline and mannitol. Despite this treatment our patient continued to have elevated intracranial pressures, which were treated aggressively with non-conventional modalities including therapeutic hypothermia, barbiturate-induced coma, and external ventricular drainage. This therapy resulted in stabilization of hyperammonemia and resolution of cerebral edema. Molecular testing later revealed a hemizygous mutation within the OTC gene. Neuropsychological testing 1 year after discharge showed normal intelligence with no visual-motor deficits, minor deficits in working memory and processing speed, and slightly below average processing speed and executive functioning.
Flexible transparent conductors based on metal nanowire networks (2014)

Few conductors are transparent and flexible. Metals have the best electrical conductivity, but they are opaque and stiff in bulk form. However, metals can be transparent and flexible when they are very thin or properly arranged on the nanoscale. This review focuses on the flexible transparent conductors based on percolating networks of metal. Specifically, we discuss the fabrication, the means to improve the electrical conductivity, the large stretchability and its mechanism, and the applications of these metal networks. We also suggest some criteria for evaluating flexible transparent conductors and propose some new research directions in this emerging field.
A Remote Control System Based on Real-Time Image Processing (2009)

A novel human-computer interaction (HCI) system based on real-time image processing is proposed in this paper. With the help of infrared tracking technology, the proposed system achieves real-time processing and stable operation on an ADSP-BF533 hardware platform. Compared with the conventional remote control methods, the proposed system enables a user to control the cursor on the screen of a TV by targeting it, and provides users with new experiences of remote control. To realize such a new remote control system, cross-ratio invariant, which is an important characteristic of the projective transformation, is also studied. Experimental results show the potential of the proposed system in TV remote control.
Identification by sequence analysis of two-site posttranslational processing of the cysteine-rich outer membrane protein 2 of Chlamydia trachomatis serovar L2 (1989)

The 60,000-molecular-weight cysteine-rich outer membrane protein (OMP2) from Chlamydia trachomatis participates in the disulfide-mediated outer-membrane organization unique to this organism. In addition, this protein is a primary focus of the host immune response. We cloned and sequenced the gene for OMP2 from C. trachomatis serovar L2. A lambda gt11 recombinant that expressed an antigenic portion of this protein was selected by antibody screening and provided a probe for the selection in lambda 1059 of a clone containing the entire gene. DNA sequencing of this clone identified one open reading frame of 1,641 base pairs, starting with a methionine codon and coding for a polypeptide with a molecular weight of 58,792. Amino-terminal protein sequencing and analysis of the translated DNA sequence demonstrated that processing at alternate signal peptide cleavage sites accounts for the molecular-weight polymorphism of this protein. The mature proteins had a net positive charge and contained 24 cysteine residues.
Ultra-thin high density capacitors for advanced packaging solutions (2015)

The growing demand on small system solutions is driving the compression of many functions into small package outline. This requires sophisticated solutions to avoid external circuitry area when integrating passive components. Moreover, decoupling capacitors need to be placed as close as possible to the active circuits in order to suppress cross-coupling between different power planes efficiently. In our paper we present the concept, fabrication and characterization results of ultra-Thin silicon capacitors that can be integrated into chip package or embedded in PCB. High capacitance densities are achieved by using high-k materials as dielectric supporting a broad application range from RF-filtering to decoupling and energy buffering. Based on characterization results of voltage and temperature characteristics it is shown that this concept offers good electrical properties and linearity compared to conventional ceramic capacitors, like MLCC.
Microparticle transport and concentration with surface acoustic waves (2013)

We describe lithium niobate SAW devices and PDMS microfluidic channels with which we study microparticle movement. We generate standing surface acoustic waves (with wavelengths of 200 micrometers) and show that microparticles (between 5 and 35 micrometers in diameter) move to nodes or antinodes. We report measurements of device response in the presence and absence of the microfluidic channel, which we combine with finite element simulation modeling to extract estimates of the PDMS damping.
Two-dimensional optical architectures for the receive mode of phased-array antennas (1999)

We propose and experimentally demonstrate two optical architectures that process the receive mode of a p x p element phased-array antenna. The architectures are based on free-space propagation and switching of the channelized optical carriers of microwave signals. With the first architecture a direct transposition of the received signals in the optical domain is assumed. The second architecture is based on the optical generation and distribution of a microwave local oscillator matched in frequency and direction. Preliminary experimental results at microwave frequencies of approximately 3 GHz are presented.
Isolation and developmental expression of Bcp1, an anther-specific cDNA clone in Brassica campestris. (1991)

Differential screening of a mature Brassica campestris pollen cDNA library has identified five cDNA clones that represent transcripts expressed exclusively, or at elevated levels, in pollen. We show here that the expression of one of these, clone Bcp1, is tissue specific and temporally regulated. The gene is activated during microspore development, as detected by in situ hybridization. Expression is enhanced at the time of pollen maturation and during pollen germination. In situ hybridization has also shown that Bcp 1 is activated in the tapetal cells in early anther development and continues to be expressed until tapetal dissolution. Homologous transcripts are present in pollen of other taxa of Brassicaceae including Arabidopsis, but not in pollen of any other families tested.
The First Taste of Africa (2009)

The author arrives at False Bay, describes his landlord and family, and is received by the Commandant of the British troops. He notes his landlord's improper conduct, proceeds to Cape Town in Africa, describes the town and the character of the Dutch inhabitants as well as their conduct towards slaves. He also describes the climate; notes the fruits, vegetables, animals, and other productions; meets with several Mohammedans; and sells his slave and some other property in order to support his expenses. The Danish ship is brought from False Bay to Table Bay, its captain prosecuted for plundering the vessel in the river Ganges, and his ship thereby prevented from departing. The other passengers prosecute the captain, and recover half the passage for England.
Interpretation of Three-Dimensional Seismic Data (2011)

This publication is the definitive, and now classic, text on the subject of interpretation of 3-D seismic data. Conceived in 1979 and first published in 1986, the book helps geoscientists extract more information from their seismic data and improve the quality of their interpretations.
BAR-CD8 T-Cell Mediated Targeted Killing of Inhibitor Producing FVIII-Specific B Cells (2015)

Abstract Anti-FVIII antibody (inhibitor) formation is a major complication in the treatment of Hemophilia A. Our lab has focused on developing novel approaches to modulate inhibitor formation by regulation of FVIII-specific T effectors that recognize FVIII and "help" B cells to produce antibodies to FVIII. As an alternative approach, in this presentation, we directly target anti-FVIII B cells. Therefore, we have developed a novel chimeric antigen-like receptor called B-cell antibody recognizing receptor (BAR) to target and directly kill the FVIII-specific B cells and antiobody-producing cells . Our BAR comprises of FVIII-domain C2 attached to T cell signaling CD28 and CD3ζ elements. We reasoned that CD8 T cells transduced to express the FVIII C2 should trigger cytotoxicity upon recognition by and interaction with specific B cells. We expressed the C2-BAR or Ova-BAR (control) in human T cells and demonstrated expression by flow cytometry. These BAR CD8 T cells also proliferated upon addition of anti-C2 or anti-Ova, respectively post 72 hrs. For proof of principle that these BAR-expressing CD8 T cells can kill specific B cells, the following basic experiment was designed. Mouse CD8 T cells transduced to express C2-BAR were co-cultured with FVIII-specific hybridomas (expressing surface IgG anti-C2) at a various ratios. After 5 hours, we measured antibody secretion by ELIspot assay. Our results demonstrated suppression of antibody secretion by C2 BAR expressing CD8 T cells, but not by control Ova-expressing BAR CD8s. These results provide evidence that BAR CD8 T cells expressing FVIII domains can be used to target specific B cells to suppress inhibitor formation, and may also provide a platform to treat other undesirable antibody responses. (Supported in part by a Pfizer ASPIRE award and NIH grant HL061883) Disclosures Zhang: Henry Jacksopn Foundation: Other: patent filed. Kim:Henry Jackson Foundation: Other: patent filed. Scott:Henry Jackson Foundation: Other: patent filed.
<i>In vitro</i> tendon cell colony growth rates on synthetic fibers (1990)

Abstract Effective integration of synthetic fiber scaffold materials into connective tissues depends to a great degree on tissue attachment and ingrowth into the material. The authors have developed an experimental model that utilizes rat tendon explants to test the rates of cell colony formation on different types of synthetic fibers that are used as tendon and ligament scaffolds and for other medical uses. It was found that cell colony growth rates are linear on all 12 types of fibers tested. This agrees with the results of previous studies involving cell growth on synthetic fiber matrices. While most synthetic fibers showed similar colony growth rates, an overall trend was observed toward increased colony growth rates on fibers with relatively hydrophilic surfaces. One type of fiber that showed significantly increased colony growth rates was covalently coated with type I collagen. It was concluded that whereas most types of synthetic fibers had similar cell growth, a collagen coating can significantly enhance cell growth.
[Effect of damaged liver parenchyma, renal insufficiency and hemodialysis on the pharmacokinetics of cyclophosphamide and its activated metabolites]. (1980)

Patients with impaired liver function have a reduced biotransformation rate of the cytostatic agent cyclophosphamide. With pathologically reduced serum cholinesterase activity the half-life of the drug increases from normally 4.3 h to 6.7 h. These patients show significantly lower peak levels of activated cyclophosphamide (4-hydroxy-cyclophosphamide + aldophosphamide). Because of the low renal clearance of cyclophosphamide (16 ml/min) and equally low renal excretion of activated cyclophosphamide amounting to only 1% of the applied dose more than 80% of the drug is still metabolized and the area under the curve of activated cyclophosphamide (cXt) remains relatively constant. No change in the pharmacokinetics of cyclophosphamide and its activated metabolite is observed in an anuric patient. However, an accumulation of toxic, directly alkylating metabolites with a fourfold alkylation rate of plasma proteins is found in this case. Hemodialysis sufficiently eliminated the toxic alkylating metabolites without a measurable influence on the pharmacokinetics of activated cyclophosphamide.
A Summary of Soviet Activities in the Design of Fault-Tolerant Digital Machines (1971)

This paper is a summary of the principal conclusions that can be made from a rather extensive survey of the open Soviet literature in the technical areas relevant to the design of reliable digital computers. Particular emphasis in the survey was on the various techniques for the constructive application of redundancy in order to achieve the reliability necessary for the successful realization of machines of high computational power and high availability. In this summary overall conclusions are presented regarding the nature and significance of Soviet activities in these fields. <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup>
A Low-Spurious Low-Power 12-bit 160-MS/s DAC in 90-nm CMOS for Baseband Wireless Transmitter (2007)

A low-spurious low-power 12-bit 160-MS/s digital to analog converter (DAC) for baseband wireless transmitter is proposed and demonstrated. Degenerated current switches are introduced and benefits of using them are discussed. Mismatch behavior under packaging-induced die stress is also presented. The mobility shift caused by package stress inherited from a thin-die is a dominant source of I/Q mismatch. A 2-channel I/Q DAC core consumes 4 mA with a 1.3/2.6 V dual supply. The 0.13 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> I/Q DAC core fabricated in 90-nm digital CMOS process with a highly-integrated digital processor achieves 74 dB SFDR, 55 dB SNDR, and -73 dB THD for a 975 kHz sinusoid at 153.6 MS/s sample rate.
A study on the characteristics of antiplasticized polycarbonates and their optical disk substrates (2004)

Abstract The characteristics of antiplasticized polycarbonates (PC) and their optical disk substrates were investigated. Meta‐terphenyl (m‐tPh) was chosen as an antiplasticizer. Blends of PC with small amounts of added m‐tPh were injection molded to form optical disk substrates. The flow properties of the blends were significantly improved by the common plasticizing effect of antiplasticizer at the melt state. The effect also induced reduction in internal stress, causing birefringence of the substrate. The increased stiffness and decreased glass transition temperature of the antiplasticized PC caused better flatness of the substrate and better microreplication of the groove geometry, respectively. It also resulted in embrittlement of the substrates, known to be a typical characteristic of antiplasticization. The antiplasticizer decreased the water absorption of the blends and also caused increased stiffness of the blends. The increased stiffness was associated with the elimination of secondary mechanical loss transition at low temperatures. From these results, the ideal viscoelastic property behavior of a polymer for an optical disk substrate to achieve better microreplication, better flatness, and low birefringence was proposed; that is, exhibiting lower modulus above glass transition temperature and higher modulus at the regions below glass transition temperature for the polymer of interest. Polym. Eng. Sci. 44:1877–1884, 2004. © 2004 Society of Plastics Engineers.
<b>Fluorocarbon Nitrogen Compounds. VIII. Mono-, Di-, Tri- and Tetra-acyl Derivatives, Oxadiazoles and ω-Bromo Acyl Isocyanates</b> (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFluorocarbon Nitrogen Compounds. VIII. Mono-, Di-, Tri- and Tetra-acyl Derivatives, Oxadiazoles and ω-Bromo Acyl IsocyanatesJohn A. Young, William S. Durrell, and Richard D. DresdnerCite this: J. Am. Chem. Soc. 1962, 84, 11, 2105–2109Publication Date (Print):June 1, 1962Publication History Published online1 May 2002Published inissue 1 June 1962https://pubs.acs.org/doi/10.1021/ja00870a021https://doi.org/10.1021/ja00870a021research-articleACS PublicationsRequest reuse permissionsArticle Views434Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
An open clinical trial of naltrexone for amphetamine dependence: Compliance and tolerability (2005)

The aim of the study was to assess the feasibility of naltrexone as a potential pharmacotherapy for amphetamine dependence. The study design was an open-label clinical trial with 20 amphetamine-dependent patients receiving 12 weeks of treatment comprised of naltrexone (50 mg) along with relapse prevention therapy. Patients were assessed weekly for adverse events and compliance to medication. Tolerability to naltrexone was measured by patient's self-report and observed adverse effects along with plasma markers of hepatotoxicity. Compliance to treatment was measured by number of treatment days attended and by the presence of naltrexone's metabolite, 6-beta-naltrexol in urine. Majority of the patients tolerated the medication well, also during relapse. Mild headache, nausea and abdominal pain were reported (n=3) but subsided within 2 weeks. Plasma levels of hepatic markers did not reveal any significant increase from baseline. Eleven out of 20 patients complied with the treatment and there was a significantly higher proportion of positive tests of 6-beta-naltrexol in urine among patients completing 12 weeks of treatment compared to those who did not (77% vs. 22%). The frequency and amount of amphetamine consumed was significantly lower during treatment compared with pre-treatment consumption (P<0.01). In conclusion, naltrexone was well tolerated with moderate rates of compliance, supporting the feasibility of investigating this compound in a larger placebo-controlled trial as a potential pharmacotherapy for amphetamine dependence.
High density overlay interconnect (HDI) delivers high frequency performance for GaAs systems (2002)

The authors point out that large die size, high gate and transistor count digital GaAs devices present problems to the system designer, such as efficient distribution of low voltage, high current power supply bias (2 VDC at 25 A, and greater). The effective delivery of such electrical power must also allow for efficient removal of the heat generated by the electronics circuits. By exploiting appropriate MCM technology, these thermal concerns are satisfied while eliminating to a maximum extent conventional circuit packaging parasitics which limit performance of high frequency systems. The overlay interconnect MCM approach used by GE/TI places IC chips first, into a structure for the most advantageous thermal management, while eliminating conventional packaging resistance, inductance and capacitance effects. Several designs constructed with overlay interconnect demonstrate the highest frequency operation and thermal performance of MCMs to date. System designs with 400 MHz and greater clock operation and dissipating 50 W are described.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
G-Pointing: Articulated Centrifuge for Real-Time G Flight Simulation (2011)

Advances in flight simulator performance fidelity, structural and mechanical design techniques and aerospace physiology research have enabled the development of a new generation of flight simulators. Through the integration of a high performance planetary motion centrifuge with a gimbaled, flyable, cockpit module, this new class of motion system is capable of replicating G forces experienced in flight. All axes accelerations are utilized to actuate the gimbal system that can be rotated in pitch and roll to align the cockpit with the centrifugal and tangential acceleration generated by the centrifuge. The effect of this softwarehardware system is to constantly align the G-vector at the pilot’s seat to the direction in flight. These devices have come to be known as Continuous G Devices (CGDs). This paper discusses the mechanical hardware behind CGDs in addition to physiological factors involved in both hardware and software design. It further explains the integration of flight simulation architecture into the motion of the device. Rudimentary parameters are examined for accuracy in CGD flight simulation. Additionally, practical evaluations of tactical aviation, commercial aircraft upset prevention and recovery to sub-orbital and orbital space flight are presented. Comparisons are made between simulator performance and current regulatory requirements for legacy devices where applicable. Finally a synopsis of research demonstrating the performance of these devices is presented.
Electron-beam damage in cathodochromic sodalite (1974)

In recent years sodalite, Na8Al6Si6O24X2, where X is Cl, Br, or I, has received wide attention as a cathodochromic material. The utility of sodalite, however, is severely restricted because of damage produced after repeat write-erase cycles. This damage was investigated and found to be of two kinds. The first kind was considerable loss of potential color centers, i.e., after a certain number of write-erase cycles the material would not color up to the original optical density. The second kind was build up of permanent coloration which could not be removed on exposure to bleaching light but could be removed by heat. Electron microprobe, electron spectroscopy for chemical analysis, thermogravimetric analysis, x rays, and a variety of other analytical tools were used to understand the causes of damage. Considerable loss of sodium and a smaller loss of halogen ions on continued electron-beam irradiation was found to be closely associated with the damage. Possibility of heat generated by the electron beam was discounted as the source of damage.
Highly Rigid Diphosphane Ligands with a Large Dihedral Angle Based on a Chiral Spirobifluorene Backbone (2005)

High and wide: The high rigidity and large dihedral angle of chiral, spirobifluorene-based diphosphane ligands lead to excellent reactivity and enantioselectivity in the ruthenium-catalyzed asymmetric hydrogenation of α,β-unsaturated carboxylic acids (see scheme).