gebhart/patrepeval huggingface dataset:
Ketoconazole-induced liver damage. (1998)

Five cases (four females, one male) of ketoconazole-related liver damage are presented, two of whom died. All patients received ketoconazole (400 mg/day) for various mycoses. In the four women the first signs of hepatotoxicity appeared after four weeks of therapy. One fatal case developed massive necrosis with fulminant liver failure and the other, submassive necrosis. In four cases cholestasis was a prominent finding. Biochemical evidence of biliary stasis may persist for several months, as occurred in the three surviving patients of our series. The two fatal cases continued receiving the drug in spite of its adverse effects. Consequently, repeated evaluation is recommended to detect early signs of liver environment.
The use of a modified fly ash as an adsorbent for lead (2000)

Coal fly ash was modified by hydrothermal treatment with NaOH solutions of varying concentrations. During the modification the zeolites, Na-Pl and hydroxysodalite, were synthesised. Increasing base concentration led to hydroxysodalite being the preferred product. Elemental analysis revealed that the modification treatment preferentially leached Si from the fly ash at low base concentrations. Elevated base concentrations, however, resulted in Al also being leached as well as the inclusion of Na in the zeolitic product. The modification activated the fly ash significantly with respect to specific surface area (SSA) and cation exchange capacity (CEC). SSA increased from 1.0 m 2 .g -1 to a maximum of 62.7 m 2 .g -1 while CEC rose from 25 mmol/100 g to a maximum of 300 mmol/100 g. Metal sorption studies were performed with lead as the metal of choice. Adsorption experiments at pH = 5, revealed that all modified ash samples adsorbed significantly more Pb than the raw ash. The best adsorption was obtained for ash, modified with 3M NaOH. 3M NaOH-modified ash also proved the most effective sorbent when adsorption was determined as a function of pH.
Pattern Separation in the Human Hippocampal CA3 and Dentate Gyrus (2008)

Pattern separation, the process of transforming similar representations or memories into highly dissimilar, nonoverlapping representations, is a key component of many functions ascribed to the hippocampus. Computational models have stressed the role of the hippocampus and, in particular, the dentate gyrus and its projections into the CA3 subregion in pattern separation. We used high-resolution (1.5-millimeter isotropic voxels) functional magnetic resonance imaging to measure brain activity during incidental memory encoding. Although activity consistent with a bias toward pattern completion was observed in CA1, the subiculum, and the entorhinal and parahippocampal cortices, activity consistent with a strong bias toward pattern separation was observed in, and limited to, the CA3/dentate gyrus. These results provide compelling evidence of a key role of the human CA3/dentate gyrus in pattern separation.
A new room decoration assistance system based on 3D reconstruction and integrated service (2008)

This paper introduces a room decoration assistance system that delivers a new interactive 3D service to mobile customers. First we analyze the requirements of room decoration system. Then an intelligent solution base on an efficient 3D reconstruction algorithm and integrated network are provided. The new approach makes use of the mobility property of the wireless service and the computing power of the home multimedia terminal. Visual results on real images are shown to demonstrate the effectiveness of the new 3D reconstruction algorithm. This new system brings new richly interactive 3D experience to customers and takes advantage of the intergraded network such as three screen services to deliver the service.
Gene Transfer in Human Vestibular Epithelia and the Prospects for Inner Ear Gene Therapy (2008)

Transfer of exogenous genetic material into the mammalian inner ear using viral vectors has been characterized over the last decade. A number of different viral vectors have been shown to transfect the varying cell types of the nonprimate mammalian inner ear. Several routes of delivery have been identified for introduction of vectors into the inner ear while minimizing injury to existing structures and at the same time ensuring widespread distribution of the agent throughout the cochlea and the rest of the inner ear. These studies raise the possibility that gene transfer may be developed as a potential strategy for treating inner ear dysfunction in humans. Furthermore, a recent report showing successful transfection of excised human vestibular epithelia offers proof of principle that viral gene transfer is a viable strategy for introduction and expression of exogenous genetic material to restore function to the inner ear. Human vestibular epithelia were harvested from patients undergoing labyrinthectomy, either for intractable Ménière's disease or vestibular schwannoma resection, and cultured for as long as 5 days. In those experiments, recombinant, multiply-deleted, replication-deficient adenoviral vectors were used to transfect and express a reporter gene as well as the functionally relevant gene, wild-type KCNQ4, a potassium channel gene that when mutated causes the autosomal dominant HL DFNA2.Here, we review the current state of viral-mediated gene transfer in the inner ear and discuss different viral vectors, routes of delivery, and potential applications of gene therapy. Emphasis is placed on experiments demonstrating viral transfection of human inner ear tissue and implications of these findings and for the future of gene therapy in the human inner ear.
Flexible atom receptor model study on tyrosine kinase inhibitors (2003)

A set of pyrimidine derivatives, tyrosine kinase inhibitors were investigated by using flexible atom receptor model. 3D-QSAR models were built with high correlation coefficients. The prediction results of these models on the biological activity of compounds in the test set show that they have high predictability. The flexible atom receptor model also gives the pseudo receptor model, which indicates possible, interactions between the receptor and the ligands. The possible interactions include two hydrogen bonds, one hydrophobic interaction and one sulfur-aromatic interaction, which is highly accordant with the Novartis pharmacophore model.
Nuclear chromatin texture in prostatic lesions. I. PIN and adenocarcinoma. (1998)

The described changes may lend themselves to the monitoring of lesion progression or of response to treatment or to chemopreventive intervention.
Traumatic retrosternal dislocation of the sternoclavicular joint of a young adult with generalised ligamentous laxity (2008)

10.1016/j.injury.2008.03.009
Regioselective Synthesis of Nitrones by Decarboxylative Oxidation of <i>N</i>-Alkyl-<i>α</i>-amino Acids and Application to the Synthesis of 1-Azabicyclic Alkaloids (1999)

Abstract Tungstate-catalyzed oxidation of N-alkyl-α-amino acids with 30% H2O2 solution under phase-transfer conditions gives nitrones regioselectively in good yields. Using this method, stereodivergent synthesis of (R)- and (S)-4-(t-butyldimethylsilyloxy)-1-pyrroline N-oxides ((R)-17a and (S)-17a) was achieved. In addition, (R)- and (S)-3-(t-butyldimethylsilyloxy)-1-pyrroline N-oxides ((R)-45 and (S)-45) were prepared by catalytic oxidation of the corresponding chiral pyrrolidines in a regioselective manner. These chiral cyclic nitrones, 17 and 45 are versatile intermediates for the synthesis of optically active nitrogen heterocycles, since stereoselective additions of carbon nucleophiles to these chiral nitrones can be readily performed. Typically, ZnI2-mediated addition of ketene t-butyldimethylsilyl methyl acetal (29a) to (R)-17a gave the cis-adduct, methyl (2R,4R)-[1,4-bis(t-butyldimethylsilyloxy)pyrrolidin-2-yl]acetate (cis-30). In contrast, the addition of lithium acetylides 34 to the nitrone (R)-17a gave the trans-adducts, (2S,4R)-2-(1-alkynyl)-4-(t-butyldimethylsilyloxy)-1-hydroxypyrrolidines trans-35. These adducts are useful intermediates for syntheses of the nitrogen heterocycles (3R,5R)-1-aza-3-hydroxybicyclo[3.3.0]octane (37) and (6R,8R)-1-aza-8-hydroxybicyclo[4.3.0]nonane (38), respectively. The ZnI2-mediated addition of ketene silyl acetal 29a to the nitrone (R)-45 gave methyl (2S,3R)-[1,3-bis(t-butyldimethylsilyloxy)pyrrolidin-2-yl]acetate (trans-50a), which was used for asymmetric synthesis of the Geissman–Waiss lactone ((−)-49).
2-Aminothiazole Functionalized Polystyrene for Selective Removal of Au(III) in Aqueous Solutions (2014)

A new chelating resin, polystyrene-2-aminothiazole (PS-AT), was synthesized via one-step reaction by grafting 2-aminothiazole in a chloromethylated polystyrene polymer. Its structure was characterized by elemental analysis and infrared spectroscopy. Batch experiments were applied to investigate the adsorption properties of PS-AT for Au(III) ions. The resin exhibits an excellent selectivity for Au(III) ions in the presence of Ni(II), Cu(II), Cd(II), and Co(II) ions. The maximum adsorption capacity obtained at 308 K was 733.8 mg/g. The adsorption kinetic and equilibrium data were well fitted to the pseudo-second-order model and the Langmuir isotherm model, respectively. Desorption of gold from the resin can be achieved using 60 mL of 2 mol/L HCl-10% thiourea solution with a desorption ratio of 93.8%. The XPS data, along with IR spectra, revealed that gold was adsorbed on the surface of PS-AT in the form of chloride, and nitrogen and sulfur were involved in the chelation of gold chloride.
Cloning of the dapB gene, encoding dihydrodipicolinate reductase, from Mycobacterium tuberculosis (1997)

Diaminopimelate (DAP) is used by bacteria for the synthesis of lysine. In many species of bacteria, including mycobacteria, DAP is also used for peptidoglycan biosynthesis. In this report we describe the cloning of the dapB gene encoding dihydrodipicolinate reductase (DHPR), which catalyzes a key branch point reaction in the bacterial DAP biosynthetic pathway, from Mycobacterium tuberculosis. Analyses of the DapB proteins from different bacterial species suggest that two different classes of DHPR enzymes may exist in bacteria.
Seamless Montage for Texturing Models (2010)

Abstract We present an automatic method to recover high‐resolution texture over an object by mapping detailed photographs onto its surface. Such high‐resolution detail often reveals inaccuracies in geometry and registration, as well as lighting variations and surface reflections. Simple image projection results in visible seams on the surface. We minimize such seams using a global optimization that assigns compatible texture to adjacent triangles. The key idea is to search not only combinatorially over the source images, but also over a set of local image transformations that compensate for geometric misalignment. This broad search space is traversed using a discrete labeling algorithm, aided by a coarse‐to‐fine strategy. Our approach significantly improves resilience to acquisition errors, thereby allowing simple and easy creation of textured models for use in computer graphics.
Reduced Inflammation and Tissue Damage in Transgenic Rabbits Overexpressing 15-Lipoxygenase and Endogenous Anti-inflammatory Lipid Mediators (2003)

PGs and leukotrienes (LTs) mediate cardinal signs of inflammation; hence, their enzymes are targets of current anti-inflammatory therapies. Products of arachidonate 15-lipoxygenases (LO) types I and II display both beneficial roles, such as lipoxins (LXs) that stereoselectively signal counterregulation, as well as potential deleterious actions (i.e., nonspecific phospholipid degradation). In this study, we examined transgenic (TG) rabbits overexpressing 15-LO type I and their response to inflammatory challenge. Skin challenges with either LTB(4) or IL-8 showed that 15-LO TG rabbits give markedly reduced neutrophil (PMN) recruitment and plasma leakage at dermal sites with LTB(4). PMN from TG rabbits also exhibited a dramatic reduction in LTB(4)-stimulated granular mobilization that was not evident with peptide chemoattractants. Leukocytes from 15-LO TG rabbits gave enhanced LX production, underscoring differences in lipid mediator profiles compared with non-TG rabbits. Microbe-associated inflammation and leukocyte-mediated bone destruction were assessed by initiating acute periodontitis. 15-LO TG rabbits exhibited markedly reduced bone loss and local inflammation. Because enhanced LX production was associated with an increased anti-inflammatory status of 15-LO TG rabbits, a stable analog of 5S,6R,15S-trihydroxyeicosa-7E,9E,11Z,13E-tetraenoic acid (LXA(4)) was applied to the gingival crevice subject to periodontitis. Topical application with the 15-epi-16-phenoxy-para-fluoro-LXA(4) stable analog (ATLa) dramatically reduced leukocyte infiltration, ensuing bone loss as well as inflammation. These results indicate that overexpression of 15-LO type I and LXA(4) is associated with dampened PMN-mediated tissue degradation and bone loss, suggesting that enhanced anti-inflammation status is an active process. Moreover, they suggest that LXs can be targets for novel approaches to diseases, e.g., periodontitis and arthritis, where inflammation and bone destruction are features.
Synthesis of Yttrium–Aluminum–Garnet Hollow Microspheres by Reverse‐Emulsion Technique (2006)

Yttrium–aluminum–garnet (YAG, Y 3 Al 5 O 12 ) hollow microspheres were synthesized by reverse‐emulsion (w/o) technique starting with aqua‐based precursors of oxides. The non‐ionic surfactant was used as the emulsifying agent. The gel powders were calcined at 700°–1200°C. The synthesized powders were characterized by differential thermal analysis (DTA), thermogravimetry, Fourier transform infrared spectroscopy (FTIR), X‐ray diffraction (XRD), and scanning electron microscopy (SEM). The appearance of an exothermic peak at 932°C in the DTA curve revealed the crystallization of YAG, which was further confirmed by XRD and FTIR studies. SEM confirmed the formation of hollow microspheres.
L'elenco degli esentati dalla Dativa Reale, 1826-1868: un sussidio per la storia edilizia di Roma nel sec. XIX (1985)

Gli autori collegano serie documentarie dell'Archivio Capitolino di Roma con quelle presenti nell'Archivio di Stato di Roma al fine di ricostruire un elenco degli edifici della città che, nel corso del XIX secolo, hanno subito una radicale modernizzazione.
Designing EPDM for Production Efficiency (1989)

Abstract Since the introduction of ethylene propylene elastomers over 25 years ago, their importance has grown almost exponentially and, today, EPDM is used in a wide range of applications. The spectacular growth of EPDM is quantified by an average growth rate (over the last 10 years) of around 11% per annum. EPDM ranks third among the synthetic rubbers in importance, immediately after SBR and BR. This progression can be attributed to its unique end-use performance in highly filled rubber applications, along with excellent ozone and weathering resistance.
Development of a Murine Model of Cerebral Aspergillosis (2002)

Central nervous system (CNS) Aspergillus infection has a mortality rate in humans that approaches 95%. Because no animal models are available for studying this infection, we sought to develop a murine model of CNS aspergillosis. Inconsistent data were obtained for nonimmunosuppressed CD-1, C57BL/6, and DBA/2N mice after infection by midline intracranial injection of Aspergillus fumigatus. CD-1 mice given cyclophosphamide to produce immunosuppression had continuous pancytopenia. Dose-finding studies in CD-1 mice showed that infection with 5 x 106 conidia/mouse consistently caused 100% mortality by day 5-8; no mice died before day 3. Histologic examination of samples of brain tissue showed focal abscesses containing Aspergillus hyphae. Fungus burdens in brain were higher than those in other organs, although Aspergillus disseminated to the kidneys and the spleen. The model we established provides an opportunity to study immune responses to and therapeutic options for CNS disease in an immunologically defined, genetically manipulable, and inexpensive species.
Stereotactic Radiosurgical Pallidotomy and Thalamotomy with the Gamma Knife: MR Imaging Findings with Clinical Correlation—Preliminary Experience (1999)

Findings in this pilot study suggest that radiosurgical thalamotomy is a promising treatment for medically refractory tremor. Three-month follow-up MR studies show a ring-enhancing lesion surrounded by a variable amount of vasogenic edema. Visualization of the radiosurgical lesion and the clinical response are delayed compared to that with radio-frequency procedures.
A novel secure cloud storage architecture combining proof of retrievability and revocation (2015)

The outsourcing of data into the cloud inherently requires a mechanism to control the access capability of the users and the cloud providers. This mechanism requires efficient cryptographic primitives to achieve fine grained access control of data, proof of storage, and revocation of the authorization. In this paper, we present a secure cloud data storage architecture with the features of dynamic user construction, revocation of the authorization, and proof of storage. In the proposed architecture, we used attribute based broadcast encryption, attribute based access control, and proxy re-encryption to achieve an efficient solution.
Antiinflammatory activities of 17,21-methyl ortho esters, 17-mono- and 17,21-diesters of 6.alpha.,9.alpha.-difluorocorticosteroids (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAntiinflammatory activities of 17,21-methyl ortho esters, 17-mono- and 17,21-diesters of 6.alpha.,9.alpha.-difluorocorticosteroidsR. Gardi, R. Vitali, G. Falconi, and A. ErcoliCite this: J. Med. Chem. 1972, 15, 5, 556–558Publication Date (Print):May 1, 1972Publication History Published online1 May 2002Published inissue 1 May 1972https://pubs.acs.org/doi/10.1021/jm00275a034https://doi.org/10.1021/jm00275a034research-articleACS PublicationsRequest reuse permissionsArticle Views130Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Case 28-1985 (1985)

Presentation of CaseA 21-year-old woman was admitted to the hospital because of abdominal pain and vomiting.She was well until seven years earlier, when she first experienced severe midepigastric pain that radiated to the back, accompanied by vomiting. During succeeding years she had repeated bouts of similar pain and vomiting and was admitted to a nearby hospital on 9 or 10 occasions. The attacks were accompanied by leukocytosis but never by documented elevation of bilirubin or amylase levels. Each episode resolved after three to six days on a clear-liquid diet and narcotics, and she felt well in the intervals. . . .
Novel Volatile Azatranes of Group 4 Metals (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNovel Volatile Azatranes of Group 4 MetalsZhibang Duan, Ahmad A. Naiini, Jong-Hwan Lee, and John G. VerkadeCite this: Inorg. Chem. 1995, 34, 22, 5477–5482Publication Date (Print):October 1, 1995Publication History Published online1 May 2002Published inissue 1 October 1995https://pubs.acs.org/doi/10.1021/ic00126a017https://doi.org/10.1021/ic00126a017research-articleACS PublicationsRequest reuse permissionsArticle Views466Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
New constant frequency PWM dual convertor with synchronous rectifier (1993)

A new constant frequency PWM dual convertor which has fully regulated dual outputs is proposed. The proposed convertor is the superposition of forward convertor and flyback convertor. The switches in the forward convertor for synchronous rectification provide another degree of freedom in controlling the flyback convertor. Thus, not only forward output but also flyback output can be fully regulated by constant frequency PWM control in continuous conduction mode (CCM).
<b><u>The spray drying of pharmaceuticals</u></b> (1992)

(1992). The spray drying of pharmaceuticals. Drug Development and Industrial Pharmacy: Vol. 18, No. 11-12, pp. 1169-1206.
Bubbles (2004)

Vanitas vanitatum et omnia vanitas: bubbles are emptiness, non-liquid, a tiny cloud shielding a mathematical singularity. Born from chance, a violent and brief life ending in the union with the (nearly) infinite. But a wealth of phenomena spring forth from this nothingness: underwater noise, sonoluminescence, boiling, and many others. Some recent results on a “blinking bubble” micropump and vapor bubbles in sound fields are outlined. The last section describes Leonardo da Vinci’s observation of the non-rectlinear ascent of buoyant bubbles and justifies the name Leonardo’s paradox recently attributed to this phenomenon.
Synthesis, crystal structure and magnetic properties of a new 30 cobalt vanadate (2004)

Abstract A new cobalt vanadate compound 1 [Co 11 (H 2 O)2 V V 2 O 6 ] has been hydrothermally synthesized and characterized by the elemental analyses and the single crystal X‐ray diffraction analysis. Compound 1 crystallizes in the orthorhombic system, space group Pmna , with a =0.55646, b= 1.06900, c= 1.18452 nm, and Z=4. The magnetic susceptibility of the cobalt vanadate has been measured and indicates possible antiferromagnetic coupling between adjacent cobalt (II) (0.5432‐0.5697 nm) through bond or space.
Time Domain and Spectral Analysis of Electrograms in Man During Regular Ventricular Activity and Ventricular Fibrillation (1984)

Electrogram signals from intramyocardially placed wire electrodes were recorded in 24 open heart surgery patients during regular heart activity (RHA) and ventricular fibrillation (VF). Time domain parameters, maximal amplitudes (AMAX, UMAX), maximal derivatives (DMAX, SMAX), and power spectra in the frequency region up to 100 Hz were analyzed off-line on a digital computer. DMAX, AMAX, SMAX, and UMAX were significantly lower postoperatively than during the operation in RHA, median values reduced by 37, 23, 54, and 50 percent. Corresponding reductions in median values of 64, 39, 58, and 30 percent occurred in the transition from RHA to VF during the operation (peroperatively).