gebhart/patrepeval huggingface dataset:
Biological versus chronological ageing of oocytes, distinguishable by raised FSH levels in relation to the success of IVF treatment (2002)

Ovarian ageing affecting oocyte quality and fecundity can occur independently of chronological age. This has important practical implications whereby serum basal FSH measurement may be a valuable prognostic index, though chronological age remains important.
Object-oriented programming (1996)

article Free Access Share on Object-oriented programming Authors: Stuart Hirshfield Hamilton College, Clinton, New York Hamilton College, Clinton, New YorkView Profile , Raimund K. Ege Florida International University, Miami Florida International University, MiamiView Profile Authors Info & Claims ACM Computing SurveysVolume 28Issue 1March 1996 pp 253–255https://doi.org/10.1145/234313.234415Published:01 March 1996Publication History 2citation1,224DownloadsMetricsTotal Citations2Total Downloads1,224Last 12 Months81Last 6 weeks2 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Increased expression of ICAM-1, VCAM-1, MCP-1, and MIP-1α by spinal perivascular macrophages during experimental allergic encephalomyelitis in rats (2002)

These observations indicate that SPM play a role in promoting lymphocyte extravasation.
Calibration and Synchronization of a Robot-Mounted Camera for Fast Sensor-Based Robot Motion (2006)

For precise control of robots along paths which are sensed online it is of fundamental importance to have a calibrated system. In addition to the identification of the sensor parameters - in our case the camera calibration - we focus on the adaptation of parameters that characterize the integration of the sensor into the control system or the application. The most important of such parameters are identified best when evaluating an application task, after a short pre-calibration phase. The method is demonstrated in experiments in which a robot arm follows a curved line at high speed.
Multicompartment Micelles from ABC Miktoarm Stars in Water (2004)

By combining three mutually immiscible polymeric components in a mixed-arm star block terpolymer architecture, we have observed the formation of a previously unknown class of multicompartment micelles in dilute aqueous solution. Connection of water-soluble poly(ethylene oxide) and two hydrophobic but immiscible components (a polymeric hydrocarbon and a perfluorinated polyether) at a common junction leads to molecular frustration when dispersed in aqueous solution. The incompatible hydrophobic blocks form cores that are protected from the water by the poly(ethylene oxide) blocks, but both are forced to make contact with the poly(ethylene oxide) by virtue of the chain architecture. The structures that emerge depend on the relative lengths of the blocks and can be tuned from discrete multicompartment micelles to extended wormlike structures with segmented cores.
Effect of alpha-methyl-p-tyrosine on 3,4-dihydroxyphenylalanine (DOPA) excretion of hamsters with melanotic melanoma. (1968)

Fortner melanotic melanoma type 1 was transplanted subcutaneously into the flank of golden Syrian female hamsters. Five to 8 days later tumor growth was visible to the unaided eye and 3,4-dihydroxyphenylalanine (DOPA) was found in the urine. As the melanoma increased in size DOPA excretion also increased. Treatment with intraperitoneal injections of l-α-methyl- p -tyrosine beginning 7–10 days after transplant was associated with marked decrease in urinary DOPA output and retardation of tumor growth.
Compensation of CMOS op-amps using split-length transistors (2008)

Theoretical and experimental results are presented for op-amp compensation using split-length transistors. By using split-length devices the right-half plane zero which plagues op-amp performance can be eliminated. Experimental results indicate substantial enhancements in speed while reducing power consumption and layout area. Further, these techniques can be used to compensate op-amps when using small supply voltage (V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DD</sub> ).
Transition of Arrestin into the Active Receptor-binding State Requires an Extended Interdomain Hinge (2002)

Arrestins selectively bind to the phosphorylated activated form of G protein-coupled receptors, thereby blocking further G protein activation. Structurally, arrestins consist of two domains topologically connected by a 12-residue long loop, which we term the "hinge" region. Both domains contain receptor-binding elements. The relative size and shape of arrestin and rhodopsin suggest that dramatic changes in arrestin conformation are required to bring all of its receptor-binding elements in contact with the cytoplasmic surface of the receptor. Here we use the visual arrestin/rhodopsin system to test the hypothesis that the transition of arrestin into its active receptor-binding state involves a movement of the two domains relative to each other that might be limited by the length of the hinge. We have introduced three insertions and 24 deletions in the hinge region and measured the binding of all of these mutants to light-activated phosphorylated (P-Rh*), dark phosphorylated (P-Rh), dark unphosphorylated (Rh), and light-activated unphosphorylated rhodopsin (Rh*). The addition of 1-3 extra residues to the hinge has no effect on arrestin function. In contrast, sequential elimination of 1-8 residues results in a progressive decrease in P-Rh* binding without changing arrestin selectivity for P-Rh*. These results suggest that there is a minimum length of the hinge region necessary for high affinity binding, consistent with the idea that the two domains move relative to each other in the process of arrestin transition into its active receptor-binding state. The same length of the hinge is also necessary for the binding of "constitutively active" arrestin mutants to P-Rh*, dark P-Rh, and Rh*, suggesting that the active (receptor-bound) arrestin conformation is essentially the same in both wild type and mutant forms.
Two‐dimensional array design techniques of millimeter‐wave microstrip comb‐line antenna array (2008)

Two‐dimensional array design techniques are developed for microstrip comb‐line antenna array. Low sidelobe design is proposed in the plane parallel to the feeding line. Element radiation is controlled by both widths of the radiating element and the feeding line simultaneously. Beam‐tilting design is proposed in the perpendicular plane to the feeding line even though only two feeding lines are arranged. Microstrip slit structure is located around each radiating element in order to cancel reflections from element and slit and to achieve high design accuracy. By using these items, three antennas with different beams are developed for three‐beam switching system. Performance of these antennas is evaluated by experiments in the millimeter‐wave band.
Focal spot deconvolution using convolutional neural networks (2019)

The focal spot size of x-ray tubes as well as the pixel size and scintillator thickness limit the spatial resolution of projection images as they result in blurring and degradation of the system’s point spread function. Deblurring of those images has been a topic of research for several decades. However, it is not solved in general. In this manuscript the application of a convolutional neural network for the deblurring of x-ray projection images is presented and compared to a standard deblurrig technique. The advantages of the neural network in terms of image quality and applicability are demonstrated with simulations and measurements originating from table top and gantry based micro-CT systems.
Totally complex sumbanifolds in CaP^2 (1998)

In the present paper, some pinching theorems for the curvatures of the totally complex submanifolds of the Cayley projective plane $CaP^2$ are obtained.
The Bayesian Virtual Epileptic Patient: A probabilistic framework designed to infer the spatial map of epileptogenicity in a personalized large-scale brain model of epilepsy spread (2020)

Despite the importance and frequent use of Bayesian frameworks in brain network modeling for parameter inference and model prediction, the advanced sampling algorithms implemented in probabilistic programming languages to overcome the inference difficulties have received relatively little attention in this context. In this technical note, we propose a probabilistic framework, namely the Bayesian Virtual Epileptic Patient (BVEP), which relies on the fusion of structural data of individuals to infer the spatial map of epileptogenicity in a personalized large-scale brain model of epilepsy spread. To invert the individualized whole-brain model employed in this study, we use the recently developed algorithms known as No-U-Turn Sampler (NUTS) as well as Automatic Differentiation Variational Inference (ADVI). Our results indicate that NUTS and ADVI accurately estimate the degree of epileptogenicity of brain regions, therefore, the hypothetical brain areas responsible for the seizure initiation and propagation, while the convergence diagnostics and posterior behavior analysis validate the reliability of the estimations. Moreover, we illustrate the efficiency of the transformed non-centered parameters in comparison to centered form of parameterization. The Bayesian framework used in this work proposes an appropriate patient-specific strategy for estimating the epileptogenicity of the brain regions to improve outcome after epilepsy surgery.
Laser stripe peak detector for 3D scanners. A FIR filter approach (2004)

The accuracy of a 3D reconstruction using laser scanners is significantly determined by the detection of the laser stripe. Since the energy pattern of such a stripe corresponds to a Gaussian profile, it makes sense to detect the point of maximum light intensity (or peak) by computing the zero-crossing point of the first derivative of such Gaussian profile. However, because noise is present in every physical process, such as electronic image formation, it is not sensitive to perform the derivative of the image of the stripe in almost any situation, unless a previous filtering stage is done. Considering that stripe scanning is an inherently row-parallel process, every row of a given image must be processed independently in order to compute its corresponding peak position in the row. This paper reports on the use of digital filtering techniques in order to cope with the scanning of different surfaces with different optical properties and different noise levels, leading to the proposal of a more accurate numerical peak detector, even at very low signal-to-noise ratios.
MIF: a key player in cutaneous biology and wound healing (2010)

Owing to its implication in a range of pathological conditions, including asthma, rheumatoid arthritis, atherosclerosis, inflammatory bowel disease and cancer, the pleiotropic cytokine macrophage migration inhibitory factor (MIF) has been the subject of intensive recent investigation. In the field of dermatology, MIF is believed to be a detrimental factor in diseases such as systemic sclerosis, atopic dermatitis, psoriasis, eczema and UV radiation damage. However, its contribution to other aspects of cutaneous biology is currently unclear. Although its expression in intact skin is well characterized, little is known about MIF's role in cutaneous homoeostasis. However, recent data do identify MIF as a key player in the immune privilege of hair follicles. Similarly, although MIF is rapidly released and its local expression significantly induced upon wounding, its primary role in the ensuing repair process remains a source of contention. MIF has been identified as being a key effector of the beneficial effects of estrogen on wound repair, yet studies employing Mif null mice, recombinant MIF, and neutralizing anti-MIF antibodies have failed to provide a consensus as to whether it benefits or inhibits healing. In fact MIF appears to be able to exert both positive and negative effects, with the cell-specific relevancy of MIF in wound healing still unclear. Thus, if MIF and/or its downstream targets are to be therapeutically useful in the context of cutaneous repair, more needs to be done to establish the nature and mechanism of action of MIF and its receptors in healing wounds.
Pharmacokinetics of Human and Recombinant Leukocyte Interferon in Patients with Chronic Renal Failure Who Are Undergoing Hemodialysis (1983)

L'insuffisance renale chronique et l'hemodialyse ne modifient pas significativement la pharmacocinetique de l'interferon leucocytaire exogene a faible dose. Des modifications de la posologie sembleraient inutiles pour les malades avec une insuffisance renale chronique, qu'ils soient ou non soumis a l'hemodialyse
A model of excellence for total quality management: LETQMEX (1995)

Abstract In modern day business, it is well recognized that in order for companies to continue to survive and grow, the quality of their goods and services is of prime importance. In contemporary management in the 90s, total quality management (TQM) is a proven approach for success. It is applicable to manufacturing, services and public sectors. This paper explores what is so special about TQM and develops an excellence model based on some proven approaches adopted by the Japanese in particular. It looks at the current thinking and development of TQM. It discusses the relationship between continuous improvement and TQM.
REACTIONS OF GASEOUS, ELEMENTAL MERCURY WITH DILUTE HALOGEN SOLUTIONS (2016)

Of the hace elements known to exist in fossil fuels, mercury (Hg) has emerged as one of the greatest concerns. Mercury has been found to be emitted from combustion in at least two different chemical forms: elemental Hg and oxidized Hg compounds. Precise identification of the oxidized compounds emitted has not been accomplished to date. However, most workers in this field assume that mercuric chloride should be the predominant oxidized species. Mercuric chloride should be readily removed In a wet scrubber system because of its relatively high solubility in water. However, it has been presumed, and we have shown, that elemental Hg will pass through a wet scrubber system with little or no removal being effected. Therefore, it is important, in order to obtain a high total Hg removal, to study methods that might result in a removal of gaseous, elemental Hg from a flue-gas stream. In this regard, we have been studying the effect of dilute halogen-containing solutions on elemental Hg in gas streams of various compositions. In particular, the results of passing Hg through bubblers containing solutions of iodine, chlorine, and chloric acid are described. Mercury found in the bubbler solutions is an indication of the extent of reaction (oxidation) of elemental Hg with the halogen species, since we have found very little Hg
The Effect of Ar/H2 Plasma Pretreatments on Porous K=2.0 Dielectrics for Pore Sealing by Self-Assembled Monolayers Deposition (2012)

Self-assembled monolayers (SAMs) deposition is being recently explored to help sealing the pores of a k=2.0 material. In order to enable a covalent chemical low-k surface functionalization by SAMs, a hydroxyl groups density as high as 1 to 2.5 OH groups/nm 2 is required. This surface modification must be carefully controlled to confine the k below 10%. In this paper, the effects of plasma temperature, time and power on the SAMs deposition and plasma-induced damage are investigated. The main findings are that there is always a trade-off between surface hydroxyl groups density and bulk damage. A thick modified layer allows the SAM molecules to penetrate inside the pores which results in a decreased porosity and an increased k value with respect to correspondent plasma-treated pristine substrates.
Nutritional care of bariatric/metabolic surgery for the treatment of type 2 diabetes mellitus (2018)

Abstract: Bariatric/metabolic surgery (BMS) is highly effective in treating obese associated type 2 diabetes mellitus (T2DM) and a commonly performed surgical procedure worldwide now. However, vitamin D, calcium and iron deficiencies are commonly presented in obese patients before operation because of reduced bioavailability and poor dietary intake. These un-recognized or under-treated nutritional deficiencies might lead to devastating complications of bone, immune function, neurologic and muscular systems. Therefore, the benefit of BMS may be tempered by the associated post-operative nutritional deficiencies. Pre-operative nutritional screening and treatment thus are essential for BMS patients. The pre-operative existing nutritional deficiencies might be exacerbated after BMS due to reduced absorption, poor dietary intake and compliance with postoperative supplement instructions. Protein deficiency is the most commonly met macronutrient deficiencies after BMS. Iron, calcium and vitamin D deficiencies are commonly met micronutrient deficiencies after BMS and may bring significant clinical problems to the patients. Some micro-nutrient deficiencies, such as copper, selenium and zinc, are difficult to diagnose because difficult in assessment and frequently confounded by deficiencies in other nutrients. Therefore, post-operative nutritional supplements following established recommendations are essential for patients received BMS. In addition, all the patients should receive regular follow-up by a multidisciplinary team for the prevention and treatment of nutritional deficiencies in order to optimize the outcomes of BMS.
Use of High Pressure to Accelerate Antibody:Antigen Binding Kinetics Demonstrated in an HIV-1 p24:Anti-HIV-1 p24 Assay (1998)

A major factor in the design of highly sensitive ligand-binding assays is the need to accelerate the interaction between analyte and binding partner (or capture reagent). In early immunoassay technologies, overnight incubations with exogenously supplied binding partners at low temperatures (typically 2–8 °C) were common. More recently, however, assay results are frequently required, for both medical and commercial reasons, within a relatively short time (∼1–2 h). The need to accelerate the binding reaction is certainly becoming even more important as high-throughput instruments (where minutes are the more common time frame) become widely utilized. This problem is typically addressed in commercial instruments by adding a large excess of the exogenous binding partner or using less than optimum temperature conditions so as to drive the binding reaction as far as possible in an acceptable assay time.

High hydrostatic pressure is a powerful tool for studying the structure and function of proteins (1)(2). Very high pressures cause most proteins to denature because of irreversible changes in the secondary and tertiary structure (3). At less than the denaturation pressure, the tertiary and secondary nature of proteins are reversibly affected by changes in hydrostatic pressure (3). Although some commercial applications of high hydrostatic pressure in the field of biotechnology have been reported or proposed (4)(5), its use to control or modulate biomolecular interactions of commercial interest has received little attention to date. Here, we describe the use of high hydrostatic pressure to considerably accelerate the kinetics of …
Metabolism and Calcium Antagonism of Sodium Alginate Oligosaccharides (2007)

Sodium alginate oligosaccharides (NaAOs) consisting of a mixture of eight oligosaccharides have previously been reported to lower blood pressure. We investigated in this study the excretion of NaAOs into the urine or feces, and attempted to elucidate the mechanism for lowering blood pressure by using isolated mesenteric arteries from the rabbit. The recovery rate of P8, which is the main component of NaAOs, was 5.2% and 58.9% over 48 hours in the urine and feces, respectively. The mechanism for lowering blood pressure appeared to be NaAOs having calcium antagonist activity, especially voltage-operated calcium channels. Our results suggest that NaAOs are substantially excreted into the feces, although some of them may be absorbed internally, exerting antagonist activity towards the calcium channels, especially voltage-operated calcium channels.
Computer-aided preoperative planning in knee osteotomy. (1995)

It has been demonstrated that osteoarthritis (OA) is activity related and may worsen when joint contact stress becomes excessive due to overloading. Hence, joint alignment and loading are considered to be the key biomechanical determinants for OA. The initiation of pathologic changes in the knee has been described by the mechanism termed, "vicious cycle" in which joint axial malalignment creates excessive stresses to the localized joint cartilage/subchondral bone regions and the surrounding soft tissue which in turn produces more laxity and joint deformity and thus repeats the cyclic degradation mechanism. If this degenerative cycle can be broken with joint alignment surgery such as osteotomy, a procedure to realign the knee joint and thus redistribute joint forces applied to each compartment, performed properly and at the appropriate time, the osteoarthritic disease process can be decelerated and even reversed. The main goals of this paper are to emphasize the importance of accurate preoperative planning for osteotomy in order to properly correct joint alignment, and to justify the application of an existing computer program, OASIS (Osteotomy Analysis and Simulation Software) using plain radiographs to perform appropriate surgical planning. Normal subjects and knee osteotomy patients were studied to establish a database for the purpose of establishing the utility and efficacy of the presently proposed concept. We wish to rationalize knee osteotomy as a preferred and cost-effective treatment for patients with early symptoms of OA in the knee. This paper presents a new concept of preoperative planning for knee osteotomy based on the underlying etiology of the disease and biomechanical viewpoint with strong emphasis on surgical treatment rationales. The established principles in this paper can be applied to other joints of the body and will help implement preventive measures and other non-surgical means to manage patients with axial malalignment or early degenerative changes.
Suppression of EMI and Electromagnetic Noise in Packages Using Embedded Capacitance and Miniaturized Electromagnetic Bandgap Structures With High-k Dielectrics (2007)

A novel miniaturized simple planar electromagnetic bandgap (EBG) structure is proposed. The new structure mitigates different types of electromagnetic noise in packages. The design of the new EBG structure proposed here relies on the use of high-k dielectric material (epsiv <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">r</sub> >100), and consists of Meander lines and patches. The Meander lines serve to provide current continuity bridges between the capacitive patches. High-k dielectric material increases the capacitance of the patches substantially in comparison to commonly used material with much lower dielectric constant. Simulation results are provided to show that using the proposed EBG, it is possible to obtain a very wide stop band (~ 10 GHz) which covers the operating frequency of current processors and a wide range of the resonant frequencies of a typical package. The wideband is obtained using a unit cell of less than 2 mm.