gebhart/patrepeval huggingface dataset:
All-silicon sub-Gb/s telecom detector with low dark current and high quantum efficiency on chip (2010)

We demonstrate channel selective 0.1-Gb/s photoreceiver operation at telecom wavelength using a silicon high-Q photonic crystal nanocavity with a laterally integrated p-i-n diode. Due to the good crystal property of silicon the measured dark current is only 15 pA. The linear and nonlinear characteristics are investigated in detail, in which we found that the photocurrent is enhanced of more than 105 due to the ultrahigh-Q (Q≃105). With the help of two-photon absorption, which is visible at a surprisingly low input power of 10−8 W, the quantum efficiency of this device reaches ∼10%.
Lavender oil as a treatment for agitated behaviour in severe dementia: a placebo controlled study (2002)

Lavender oil administered in an aroma stream shows modest efficacy in the treatment of agitated behaviour in patients with severe dementia.
Enolase antigen, mannan antigen, Cand-Tec antigen, and beta-glucan in patients with candidemia (1996)

We compared the specificities and sensitivities of four tests used for the serodiagnosis of candidemia in 39 patients with candidemia, including 10 patients with superficial Candida colonization, 10 patients with deep mycosis, and 20 healthy subjects. The results obtained by the dot immunoblotting assay for detecting the enolase antigen (48 kDa) were compared with those of assays for detecting mannan antigen, heat-labile antigen (a threshold titer of four times), and beta-glucan (> or = 60 pg/ml). Enolase antigen was detected in 28 (71.8%) patients with candidemia, while 30 (76.9%), 10 (25.6%), and 27 (84.4%) patients were positive for the heat-labile antigen by the Cand-Tec assay, the mannan antigen by the Pastorex Candida assay, and beta-glucan by the limulus test, respectively. Ten patients with superficial Candida colonization, 5 patients with invasive pulmonary aspergillosis, 5 patients with cryptococcosis, and 20 healthy subjects were negative for both enolase antigen and mannan antigen. Two patients with superficial Candida colonization, one patient with invasive pulmonary aspergillosis, and two patients with cryptococcosis were positive by the Cand-Tec assay. The beta-glucan concentration was more than 60 pg/ml in all patients with invasive pulmonary aspergillosis; however, it was less than 10 pg/ml in all patients with cryptococcosis. The specificity of enolase antigen in the serodiagnosis of candidemia was 100%, but the sensitivity was 71.8%. The specificity and sensitivity of Cand-Tec, the assay for mannan antigen, and the assay for beta-glucan were 76.9 and 87.5%, 25.6 and 100%, and 84.4 and 87.5%, respectively. Our results demonstrated that antigen detection tests are useful for the diagnosis of candidemia; however, none is satisfactory for the serodiagnosis of candidemia. We suggest that a combination of two assays may increase the accuracy of diagnosis of candidiasis.
Digital Suppression of Power Amplifier Spurious Emissions at Receiver Band in FDD Transceivers (2013)

As the duplexing distances in emerging wireless systems are getting more and more narrow, achieving sufficient isolation between transmit and receive chains using radio frequency (RF) filtering alone becomes increasingly complex. Particularly challenging problem in this context is the spectral regrowth of nonlinear power amplifiers (PAs) in the transmit chain, and other transmitter out-of-band (OOB) emissions, which can heavily desensitize the receiver chain. In this letter, we first carry out detailed modeling of transmitter OOB emissions due to practical wideband PAs with memory effects. Stemming from this modeling, and using the known digital transmit data inside the transceiver as reference, we then propose an efficient nonlinear digital cancellation technique to suppress the transmitter OOB emissions in the receiver path. The proposed technique is verified and analyzed using extensive computer simulations, rendering excellent suppression properties, hence enabling sufficient TX-RX isolation in frequency division duplexing (FDD) transceivers without any extra analog/RF filtering or PA linearization.
The Delano diagram, a powerful design tool (2008)

A power density model is introduced into the Delano diagram. The correlation of the system length and the peak power density are outline especially for 2-f-systems with a low Lagrange invariant and high energy transfer.
<i>Helicobacter Pylori</i>Infection Is Significantly Associated With Metabolic Syndrome in the Japanese Population (2008)

In a large Japanese population, H. pylori infection was significantly associated with metabolic syndrome.
Eradication of<i>Propionibacterium acnes</i>by its endogenic porphyrins after illumination with high intensity blue light (2003)

Propionibacterium acnes is a Gram-positive, microaerophilic bacterium that causes skin wounds. It is known to naturally produce high amounts of intracellular porphyrins. The results of the present study confirm that the investigated strain of P. acnes is capable of producing endogenic porphyrins with no need for any trigger molecules. Extracts from growing cultures have demonstrated emission peaks around 612 nm when excited at 405 nm, which are characteristic for porphyrins. Endogenic porphyrins were determined and quantified after their extraction from the bacterial cells by fluorescence intensity and by elution retention time on high-performance liquid chromatography (HPLC). The porphyrins produced by P. acnes are mostly coproporphyrin, as shown by the HPLC elution patterns. Addition of delta-aminolevulinic acid (ALA) enhanced intracellular porphyrin synthesis and higher amounts of coproporphyrin have been found. Eradication of P. acnes by its endogenic porphyrins was examined after illumination with intense blue light at 407-420 nm. The viability of 24 h cultures grown anaerobically in liquid medium was reduced by less than two orders of magnitude when illuminated once with a light dose of 75 J cm(-2). Better photodynamic effects were obtained when cultures were illuminated twice or three times consecutively with a light dose of 75 J cm(-2) and an interval of 24 h between illuminations. The viability of the culture under these conditions decreased by four orders of magnitude after two illuminations and by five orders of magnitude after three illuminations. When ALA-triggered cultures were illuminated with intense blue light at a light dose of 75 J cm(-2) the viability of the treated cultures decreased by seven orders of magnitude. This decrease in viability can occur even after a single exposure of illumination for the indicated light intensity. X-ray microanalysis and transmission electron microscopy revealed structural damages to membranes in the illuminated P. acnes. Illumination of the endogenous coproporphyrin with blue light (407-420 nm) apparently plays a major role in P. acnes photoinactivation. A treatment protocol with a series of several illuminations or illumination after application of ALA may be suitable for curing acne. Treatment by both pathways may overcome the resistance of P. acnes to antibiotic treatment.
Semi-active and active control of frame vibration in automotive vehicles (1987)

The feasibility of reducing frame vibrations in automotive vehicles with controlled hydraulic engine mounts is investigated. Only engine idle situations are considered. Two modes of control are studied: semi-active and active. A dynamic model is developed for the semi-active hydraulic mount. The model is verified experimentally through impedance measurements. Sensitivity studies reveal the effectiveness of various parameter control schemes. Experimental implementation of the semi-active hydraulic mounts on a commercial vehicle confirm their ability to reduce frame vibration levels at engine idle speeds. A simplified vehicle system model is used to investigate frame vibration control with active engine mounts. Closed-loop control designs using variations of the LQG control design method are evaluated through simulations. A method referred to as Gain-Sensitivity Augmentation (GSA) is developed to permit LQG controller adaptation to structured plant parameter perturbations. The GSA method is applied to the application problem. Improved LQG control performance is achieved with the GSA method.
A transcriptional silencer downstream of the promoter in the osmotically controlled proU operon of Salmonella typhimurium. (1992)

The proU operon of Salmonella typhimurium is induced by conditions of high osmolality. The cis-acting sequences that mediate osmotic control of transcription were characterized by deletion analysis. The nucleotide sequence between -60 and +274 (relative to the transcription start point) is sufficient for normal osmotic control. Deletions that removed sequences upstream of position +274 but left the promoter intact resulted in greatly increased expression from the proU promoter in the absence of osmotic stress. Thus, the transcription control region of the proU operon consists of two discrete components: (i) the promoter and (ii) a negatively acting site that overlaps the coding sequence of the first structural gene of the operon, proV. That this negative regulatory element is a transcriptional terminator or mRNA processing site was ruled out. Our results suggest that the negative regulatory element behaves as a transcriptional silencer that inhibits transcription initiation at the proU promoter in medium of low osmolality by some action at a distance. We propose several possible mechanisms for the function of this regulatory site.
Inverse association between cancer and Alzheimer's disease: results from the Framingham Heart Study (2012)

Cancer survivors had a lower risk of Alzheimer's disease than those without cancer, and patients with Alzheimer's disease had a lower risk of incident cancer. The risk of Alzheimer's disease was lowest in survivors of smoking related cancers, and was not primarily explained by survival bias. This pattern for cancer is similar to that seen in Parkinson's disease and suggests an inverse association between cancer and neurodegeneration.
A Unified Sequence-to-Sequence Front-End Model for Mandarin Text-to-Speech Synthesis (2020)

In Mandarin text-to-speech (TTS) system, the front-end text processing module significantly influences the intelligibility and naturalness of synthesized speech. Building a typical pipeline-based front-end which consists of multiple individual components requires extensive efforts. In this paper, we proposed a unified sequence-to-sequence front-end model for Mandarin TTS that converts raw texts to linguistic features directly. Compared to the pipeline-based front-end, our unified front-end can achieve comparable performance in polyphone disambiguation and prosody word prediction, and improve intonation phrase prediction by 0.0738 in F1 score. We also implemented the unified front-end with Tacotron and WaveRNN to build a Mandarin TTS system. The synthesized speech by that got a comparable MOS (4.38) with the pipeline-based front-end (4.37) and close to human recordings (4.49).
On Multifunctional Collaborative Methods in Engineering Science (2019)

Engineers are challenged to produce better designs in less time and for less cost. Hence, to investigate novel and revolutionary design concepts, accurate, high-fidelity data must be assimilated rapidly into the design, analysis and simulation process. This data assimilation should consider diverse mathematical modeling and multi-discipline interactions necessitated by concepts exploiting advanced materials and structures. Integrated high-fidelity methods with diverse engineering applications provide the enabling technologies to assimilate these high-fidelity, multi-disciplinary data rapidly at an early stage in the design. These integrated methods must be multifunctional, collaborative and applicable to the general field of engineering science and mechanics. Multifunctional methodologies and analysis procedures are formulated for interfacing diverse domain idealizations including multi-fidelity modeling methods and multi-discipline analysis methods. These methods, based on the method of weighted residuals, ensure accurate compatibility of primary and secondary variables across the domain interfaces. Methods are developed for scalar-field and vector-field problems in engineering science with extensions to multidisciplinary problems. Results are presented for the scalar- and vector-field developments using example patch test problems. In addition, results for torsion, thermal, and potential flow problems are presented to demonstrate further the effectiveness of the scalar-field development. Results for plane stress and plane flow problems are presented for the vector-field development. Results for all problems presented are in overall good agreement with the exact analytical solution or the reference numerical solution. The multifunctional methodology presented provides an effective mechanism by which domains with diverse idealizations are interfaced. This capability rapidly provides the high-fidelity data needed in the early design phase. Moreover, the capability is applicable to the general field of engineering science and mechanics. Hence, it provides a collaborative capability that accounts for interactions among engineering analysis methods.
Easily Accessible 2‐(2‐Bromophenyl)‐4,4,5,5‐Tetramethyl‐[1,3,2]Dioxaborolane for Suzuki‐Miyaura Reactions (2007)

Abstract A simple and direct method has been developed for the preparation of the title compound from 1,2‐dibromobenzene. Suzuki‐Miyaura reactions of this compound with substituted bromoaryls proceeded smoothly to give 2‐bromobiphenyl derivatives in moderate to excellent yields. Instead of converting each of the bromoaryl compounds to the corresponding arylmetals followed by reacting with 2‐iodobromobenzene, the advantage of this protocol is that the substituted bromoaryls were used directly to couple with the title compound.
Bacterial Amyloids (2012)

Many bacteria can assemble functional amyloid fibers on their cell surface. The majority of bacterial amyloids contribute to biofilm or other community behaviors where cells interact with a surface or with another cell. Bacterial amyloids, like all functional amyloids, share structural and biochemical properties with disease-associated eukaryotic amyloids. The general ability of amyloids to bind amyloid-specific dyes, such as Congo red, and their resistance to denaturation have provided useful tools for scoring and quantifying bacterial amyloid formation. Here, we present basic approaches to study bacterial amyloids by focusing on the well-studied curli amyloid fibers expressed by Enterobacteriaceae. These methods exploit the specific tinctorial and biophysical properties of amyloids. The methods described here are straightforward and can be easily applied by any modern molecular biology lab for the study of other bacterial amyloids.
Activation of Sphingosine 1-Phosphate Receptor-1 by FTY720 Is Neuroprotective After Ischemic Stroke in Rats (2009)

These data suggest that activation of sphingosine 1-phosphate-1 by FTY720 reduces neuronal death after transient MCAO.
Survey on the Occurrence of Apple Diseases in Korea from 1992 to 2000 (2006)

In the survey from 1992 to 2000, twenty-eight parasitic diseases were observed in major apple producing areas in Korea. The predominant apple diseases were white rot(Botryosphaeria dothidea), Marssonina blotch(Marssonina mali), Valsa canker(Valsa ceratosperma), Alternaria leaf spot(Alternaria mali), and bitter rot(Collectotrichum gloeosporioides and C. acutatum). Apple scab that reappeared in 1990 after disappearance for 15 years was disappeared again since 1997. A viroid disease(caused by apple scar skin viroid) was newly found in this survey. The five diseases, fire blight(Erwinia amylovora), black rot(Botryosphaeria obtusa), scab(Cladosporium carpophilum), Monochaetia twig blight(Monochaetia sp.), and brown leaf spot(Hendersonia mali), which had once described in 1928 but no further reports on their occurrence, were not found in this survey. However, blossom blight(Monilinia mali), brown rot(Monilinia fructigena), and pink rot(Trichothecium roseum), which did not occur on apple after mid 1970s, were found in this survey.
Increasing the Sensitivity of Enzyme-Linked Immunosorbent Assay Using Multiplexed Electrokinetic Concentrator (2010)

We developed a novel method to increase the sensitivity of standard enzyme-linked immunosorbent assay (ELISA) using a multiplexed electrokinetic concentration chip. The poly(dimethylsiloxane) (PDMS) molecular concentrator (1) was used to trap and collect charged fluorescent product of target-bound enzyme turnover reaction of ELISA that occurred in a standard 96 well plate. Detection sensitivities of both prostate specific antigen (PSA) and CA 19-9 (a human pancreatic and gastrointestinal cancer marker) ELISAs in serum are enhanced approximately 100 fold with a low CV of <17%. We also integrated this method with an on-chip bead-based ELISA that lends itself toward a fully automated on-chip diagnostic device. Detection sensitivity of microfluidic bead-based CA 19-9 ELISA in serum is enhanced approximately 65 fold compared to the results without the electrokinetic accumulation step. This chip can be directly applied to enhance the readout sensitivity of a wide range of existing ELISA kits at concentrations below the current detection limit.
Estimation of the thickness of thin metal sheet using laser generated ultrasound (1987)

A noncontacting technique has been developed to measure the thickness of thin metal sheet by using a pulsed laser to generate both symmetric and antisymmetric Lamb waves. These have been detected with a laser interferometer. Analysis of the waveforms allows an estimation of the sheet thickness and accuracies to within 2% are attainable on sheets as thin as 27 μm.
Nonlinear acoustic echo control using an accelerometer (2009)

A typical echo canceller uses an FIR adaptive filter to estimate the impulse response of the near-end echo path. However nonlinear echo components due to the loudspeaker and driving amplifier are not captured by such an arrangement. We propose a novel scheme for nonlinear acoustic echo cancellation where an accelerometer sensor captures loudspeaker vibration and this sensor signal is used along with the error signal to adapt the adaptive filter coefficients. The accelerometer sensor is used in lieu of explicit nonlinear modeling in the echo cancelling loop and hence it is compatible with typical NLMS and RLS echo cancellation algorithms. Experiments with an accelerometer mounted on the magnet of a hands-free kit show an echo reduction improvement by as much as 15 dB in situations of nonlinear loudspeaker distortion.
Mode selectivity using selective layered and combined metallic-dielectric electrodes in slab waveguide resonators (2001)

Using selective layered, and combined metallic-dielectric electrodes, the higher order mode selectivity of the slab waveguide resonator can be improved, reducing the sensitivity of the beam quality on small variations of the electrode gap by high power CO2 lasers.
Automated lithology extraction from core photographs (2011)

Angeleena Thomas, Malcolm Rider, Andrew Curtis and Alasdair MacArthur propose a novel approach to lithology classification from core photographs based on object-based image analysis, an advanced method used in remote sensing and medical imaging.
Effects of intracoronary arterial injection of tirofiban on no-reflow phenomenon in patients with acute ST-segment elevation myocardial infarction underwent primary percutaneous coronary intervention (2017)

Objective: To compare the effect of intracoronary arterial injection of tirofiban and sodium nitroprusside (SNP) on no-reflow phenomenon in patients with acute ST-segment elevation myocardial infarction (STEMI) underwent primary percutaneous coronary intervention (PCI). Methods: A total of 68 patients with acute STEMI who had no-reflow phenomenon during PCI were chosen and randomly divided into SNP group (n = 34) and tirofiban group (n = 34). Aiming at no-reflow phenomenon during PCI, with the use of microcatheters, intracoronary arterial injection of tirofiban was given in tirofiban group, while intracoronary bolus of SNP was given in SNP group. Coronary angiography was conducted to record TIMI flow grade of the infarct-related artery after 10 minutes. Plasma brain natriuretic peptide (BNP) was monitored before and after PCI (in 24 hours). With the help of ultrasound cardiogram, left ventricular ejection fraction (LVEF), left ventricular end-diastolic dimension (LVEDD) and left ventricular endsystolic dimension (LVESD) were recorded and compared in 30 days after PCI. Results: The ratio of TIMI grade 3 blood flow in tirofiban group was significantly higher than that in SNP group [76.5% (26/34) vs. 52.9% (18/34), p = .03]. BNP levels in two groups had no statistical significance before PCI ( p = .16), but in 24 h after PCI, BNP levels in tirofiban group were significantly lower than those in SNP group [(439.00 ± 4.90) μmol/L vs. (632.00 ± 3.63) μmol/L, p = .02]. In 30 days after PCI, LVEF, LVEDD and LVESD in tirofiban group were all superior to those in SNP group (all p < .05). Conclusions: Intracoronary arterial injection of tirofiban was superior to SNP in improving no-reflow phenomenon in STEMI patients after PCI in the emergency treatment. Tirofiban therapy can increase coronary blood flow and myocardial perfusion after the occurrence of no-reflow phenomenon during PCI in STEMI patients, and improve long-term prognosis.
Bistable Optical Devices for Integrated Optics and Fiber Optics Applications (1979)

A review of bistable optical devices is given, along with a description of a new class of devices which do not require Fabry-Perot interferometers.
Neonatal infective endarteritis complicating patent ductus arteriosus (2008)

This report highlights the importance of a detailed cardiac evaluation in a neonate with persisting bacteraemia. An increasing awareness of neonatal ductal endarteritis combined with the wider availability of more sensitive echocardiography has implications for local neonatal service delivery.
Ciprofloxacin Is Actively Transported across Bronchial Lung Epithelial Cells Using a Calu-3 Air Interface Cell Model (2013)

Ciprofloxacin is a well-established broad-spectrum fluoroquinolone antibiotic that penetrates well into the lung tissues; still, the mechanisms of its transepithelial transport are unknown. The contributions of specific transporters, including multidrug efflux transporters, organic cation transporters, and organic anion-transporting polypeptide transporters, to the uptake of ciprofloxacin were investigated in vitro using an air interface bronchial epithelial model. Our results demonstrate that ciprofloxacin is subject to predominantly active influx and a slight efflux component.
United States v. Lopez 1 Fed. Sent. R. 3 Cr. No. 88-050-R, Slip Op. (C. D. Cal. May 5, 1988) (Lexis 3944) (1988)

Research Article| June 01 1988 United States v. Lopez 1 Fed. Sent. R. 3 Cr. No. 88-050-R, Slip Op. (C. D. Cal. May 5, 1988) (Lexis 3944) Hauk, Hauk Search for other works by this author on: This Site PubMed Google Scholar Hupp Hupp Search for other works by this author on: This Site PubMed Google Scholar Federal Sentencing Reporter (1988) 1 (1): 3–12. https://doi.org/10.2307/20639020 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Hauk, Hupp; United States v. Lopez 1 Fed. Sent. R. 3 Cr. No. 88-050-R, Slip Op. (C. D. Cal. May 5, 1988) (Lexis 3944). Federal Sentencing Reporter 1 June 1988; 1 (1): 3–12. doi: https://doi.org/10.2307/20639020 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentFederal Sentencing Reporter Search This content is only available via PDF. Article PDF first page preview Close Modal You do not currently have access to this content.