gebhart/patrepeval huggingface dataset:
An Analytical Model of Temperature and Stress Fields During Cold-Water Injection Into an Oil Reservoir (2006)

Summary A new transient analytical model has been developed to study the temperature and stress distribution induced by nonisothermal fluid injection, particularly conventional waterflooding. In the model, the transient pressure, temperature, and stress fields are computed consecutively. The pressure field has been computed by using either the exponential integral solution for a unit mobility ratio displacement or Ramey's composite reservoir model for a nonunit mobility ratio pistonlike displacement. The transient temperature field has been computed by using a model that can account for both the overburden heat losses and transversal heat dispersion within the reservoir. The stress distribution has been calculated with a method presented for a plane strain in a hollow cylinder. The results implied that the thermoelastic changes in the cooled zone could affect the surrounding stress fields in a profound manner. For instance, for a porous medium with stiff material (such as carbonate reservoirs) owing to cooling by the injected cold water, large-scale tensile stresses arise and may induce new fractures (or propagate existing ones) far into the reservoir. In addition, a major tangential stress concentration develops just in front of the cooled zone; hence, shear yield is highly likely to occur ahead of the thermal front. The 2D treatment of the temperature field makes the new method superior to the previous analytical models where only a 1D field has been used.
Role of gentamicin-impregnated cement in total joint arthroplasty. (1988)

Palacos-Gentamicin (PG) was used in 130 joint arthroplasties at The Hospital for Special Surgery. At an average follow-up of 2.5 years (range, 2 to 5), the overall recurrence rate of infection was 3.8 per cent. Only one (2.0 per cent) infection occurred where the bacteria were sensitive to PG and there were no infections in the two-stage reimplantation group. There have been no adverse effects from the gentamicin and the inferior intrusion properties of the PG have not been reflected in the clinical or radiographic results.
Evaluation of the probiotic potential of lactic acid bacteria isolated from faeces of breast-fed infants in Egypt (2007)

The probiotic-related characteristics of 55 strains of lactic acid bacteria isolated from the faeces of 3 - 6 months old breast-fed infants were determined. The API 50 CH and SDS-PAGE techniques were employed to ascertain the identity of the isolated strains. The predominant species among the isolated strains were Lactobacillus (Lb.) acidophilus, Lb. plantarum, Enterococcus (E.) faecium, and E. faecalis. Probiotic properties such as bile resistance, acid tolerance, and adhesion to intestinal mucous were assessed. In vitro results obtained showed that five strains, Lb. plantarum (P1 and P164), Lb. pentosus (P191), and Lb. fermentum (P10, P193) were able to meet the basic requirements for probiotic functions as they demonstrated probiotic characteristics such as tolerance to pH 3, growth in 0.4% oxgall and adhesion to intestinal mucous. The results obtained in this investigation will be used to select potentially probiotic strains for in vivo study.
FUNDAMENTAL CONSIDERATIONS ABOUT OPHTHALMOMETRY (1969)

Research Laboratories Edgewood Arsenal, Maryland Southern College of Optometry Memphis, Tennessee *Summary submitted May 18, 1969, for publication in the November. 1969, issue of the American Journal of Optometry and Archives of American Academy of Optometry. Original in Graefe's Archiv für Ophthalmologie, Bd. 151, S. 249-274, 1951. The complete English translation of this paper has been deposited with the National Translation Center. John Crerar Library, 35 W. 33rd Street, Chicago, Illinois 60616. Copies may be obtained from the Center. †Optometrist, M.S., Major, U.S. Army. Fellow, American Academy of Optometry. ‡Optometrist, M.S., Member of Faculty. Fellow, American Academy of Optometry.
Sweet memories: epigenetic control in flowering (2011)

Many plants respond to winter with epigenetic factors that gradually dampen repression of flowering so that they can flower in spring. The study of this process was important for the identification of the plant Polycomb group (PcG) of proteins and their role in the epigenetic control of plant gene expression. Fittingly, these studies continue to illuminate our understanding of PcG function. We discuss recent advances, particularly the role of noncoding RNA in the recruitment of PcG to target genes, and the role of the PcG in regulating the stem cell pool in flowers.
Therapeutic Synergy of Oral Taxane BMS-275183 and Cetuximab <b> <i>versus</i> </b> Human Tumor Xenografts (2004)

The combination of oral taxane BMS-275183 plus cetuximab provided therapeutically synergistic antitumor activity in two different human tumor xenograft models. Clinical evaluation of this combination is recommended.
Investigation on Etch Characteristics of Nanometer-Sized Magnetic Tunnel Junction Stacks Using a HBr/Ar Plasma (2011)

The etch characteristics of CoFeB magnetic films and magnetic-tunnel-junction (MTJ) stacks masked with Ti films were investigated using an inductively coupled plasma reactive ion etching in a HBr/Ar gas mix. The etch rate, etch selectivity, and etch profile of the CoFeB films were obtained as a function of the HBr concentration. As the HBr gas was added to Ar, the etch rate of the CoFeB films, and the etch selectivity to the Ti hard mask, gradually decreased, but the etch profile of the CoFeB films was improved. The effects of the HBr concentration and etch parameters on the etch profile of the MTJ stacks with a nanometer-sized 70 x 100 nm2 pattern were explored. At 10% HBr concentration, low ICP RF power, and low DC-bias voltage, better etch profiles of the MTJ stacks were obtained without redeposition. It was confirmed that the protective layer containing hydrogen, and the surface bombardment of the Ar ions, played a key role in obtaining a steep sidewall angle in the etch profile. Fine-pattern transfer of the MTJ stacks with a high degree of anisotropy was achieved using a HBr/Ar gas chemistry.
Oncogenic Ha-Ras-induced Signaling Activates NF-κB Transcriptional Activity, Which Is Required for Cellular Transformation (1997)

Ras proteins function in stimulating cell proliferation and differentiation through the activation of Raf-dependent and Raf-independent signal transduction pathways and the subsequent activation of specific transcription factors. The transcription factor NF-kappaB has been widely studied as a regulator of genes involved in immune and inflammatory responses. A variety of stimuli activate NF-kappaB through the induced phosphorylation and degradation of the inhibitor IkappaB followed by nuclear translocation of NF-kappaB. We show here that oncogenic forms of Ha-Ras activate NF-kappaB, not through induced nuclear translocation, but rather through the activation of the transcriptional function of the NF-kappaB RelA/p65 subunit. Importantly, RelA/p65 -/- cells are inefficient in the activation of kappaB-dependent gene expression in response to oncogenic Ras expression. Furthermore, IkappaBalpha expression blocks focus formation in NIH3T3 cells induced by oncogenic Ras. These results demonstrate that NF-kappaB is a critical downstream mediator of Ha-Ras signaling and oncogenic potential.
cGMP Produced by NO-Sensitive Guanylyl Cyclase Essentially Contributes to Inflammatory and Neuropathic Pain by Using Targets Different from cGMP-Dependent Protein Kinase I (2008)

A large body of evidence indicates that the release of nitric oxide (NO) is crucial for the central sensitization of pain pathways during both inflammatory and neuropathic pain. Here, we investigated the distribution of NO-sensitive guanylyl cyclase (NO-GC) in the spinal cord and in dorsal root ganglia, and we characterized the nociceptive behavior of mice deficient in NO-GC (GC-KO mice). We show that NO-GC is distinctly expressed in neurons of the mouse dorsal horn, whereas its distribution in dorsal root ganglia is restricted to non-neuronal cells. GC-KO mice exhibited a considerably reduced nociceptive behavior in models of inflammatory or neuropathic pain, but their responses to acute pain were not impaired. Moreover, GC-KO mice failed to develop pain sensitization induced by intrathecal administration of drugs releasing NO or carbon monoxide. Surprisingly, during spinal nociceptive processing, cGMP produced by NO-GC may activate signaling pathways different from cGMP-dependent protein kinase I (cGKI), whereas cGKI can be activated by natriuretic peptide receptor-B dependent cGMP production. Together, our results provide evidence that NO-GC is crucially involved in the central sensitization of pain pathways during inflammatory and neuropathic pain.
<i>Bag‐1</i> and <i>Bcl‐2</i> Gene Transfer in Malignant Glioma: Modulation of Cell Cycle Regulation and Apoptosis (2000)

Bag-1 is a heat shock 70 kDa (Hsp70)-binding protein that can collaborate with Bcl-2 in suppressing apoptosis under some conditions. Here, we report that 11 of 12 human glioma cell lines express Bag-1 protein in vitro. Moreover, 15 of 19 human glioblastomas expressed Bag-1 as assessed by immunohistochemistry in primary tumor specimens. To examine the biological effects of Bag-1 in glioma cells, we expressed Bag-1 or Bcl-2 transgenes in 2 human malignant glioma cell lines, LN-18 and LN-229. Bag-1 significantly slowed glioma cell growth and reduced clonogenicity of both cell lines in vitro. Coexpressed Bcl-2 abrogated these effects of Bag-1. Intracranial LN-229 glioma xenografts implanted into nude mice revealed a substantial growth advantage afforded by Bcl-2. Bag-1 had no such effect, either in the absence or presence of Bcl-2. Upon serum starvation in vitro, Bcl-2 prevented cell death whereas Bag-1 did not. Both Bcl-2 and Bag-1 slowed proliferation of serum-starved cells when expressed alone. Importantly, coexpression of Bcl-2 and Bag-1 provided a distinct growth advantage under conditions of serum starvation that is probably the result of (i) the death-preventing activity of Bcl-2 and (ii) the property of Bag-1 to overcome a Bcl-2-mediated enhancement of exit from the cell cycle. In contrast to these Bcl-2/Bag-1 interactions observed under serum starvation conditions, Bag-1 did not further enhance the strong protection from staurosporine-, CD95 (Fas/Apo1) ligand-, Apo2 ligand (TRAIL)- or chemotherapeutic drug-induced apoptosis afforded by Bcl-2. Taken together, these results indicate a role for Bag-1/Bcl-2 interactions in providing a survival advantage to cancer cells in a deprived microenvironment that may be characteristic of ischemic/hypoxic tumors such as human glioblastoma multiforme, and suggest that Bcl-2/Bag-1 interactions also modulate cell proliferation.
Mercury-free PVT apparatus for thermophysical property analyses of hydrocarbon reservoir fluids (1992)

Typical reservoir fluid analyses of complex, multicomponent hydrocarbon mixtures include the volumetric properties, isothermal compressibility, thermal expansivity, equilibrium ratios, saturation pressure, viscosities, etc. These parameters are collectively referred to as PVT properties, an acronym for the primary state variables; pressure, volume, and temperature. The reservoir engineer incorporates this information together with the porous media description in performing material balance calculations. These calculations lead to the determination (estimation) of the initial hydrocarbon in-place, the future reservoir performance, the optimal production scheme, and the ultimate hydrocarbon recovery. About four years ago, Ruska Instrument Corporation embarked on a project to develop an apparatus designed to measure PVT properties that operates free of mercury. The result of this endeavor is the 2370 Hg-Free PVT system which has been in the market for the last three years. The 2370 has evolved from the prototype unit to its present configuration which is described briefly in this report. The 2370 system, although developed as a system-engineered apparatus based on existing technology, has not been exempt from this burden-of-proof Namely, the performance of the apparatus under routine test conditions with real reservoir fluids. This report summarizes the results of the performance and applications testing of the 2370 Hg-Free PVT system. Density measurements were conducted on a pure fluid. The results were compared against literature values and the prediction of an equation of state. Routine reservoir fluid analyses were conducted with a black oil and a retrograde condensate gas mixtures. Limited comparison of the results were performed based on the same tests performed on a conventional mercury-based PVT apparatus. The results of these tests are included in this report.
Expression of CD44v6 in advanced gastric cancer and its relationship to hematogenous metastasis and long‐term prognosis (2002)

CD44v6 protein may have an important role in hematogenous metastasis, and may be a biologic marker of prognostic significance in differentiated type gastric cancers.
Green‐Emitting CePO<sub>4</sub>:Tb/LaPO<sub>4</sub> Core–Shell Nanoparticles with 70 % Photoluminescence Quantum Yield (2003)

Quantum leap: Very high quantum yields, thought to be impossible for nanocrystalline phosphor materials, were achieved with CePO4:Tb/LaPO4 core–shell nanoparticles (see picture). Because the LaPO4 shell reduces energy losses at the particle surface, transparent colloidal solutions of these 8-nm particles are highly photoluminescent.
Ligand kinetics of hemoglobin S containing erythrocytes. (1977)

Oxygen uptake of fully deoxygenated sickle (SS) erythrocytes is slower than that of normal (AA) erythrocytes, as demonstrated by the half-times of the overall oxygenation reactions: at 25 degrees in an isotonic phosphate buffer the normal red cells have a t1/2 = 82 +/- 4.7 msec, as compared to sickle red cells where t1/2 = 135 +/- 17.6 msec. The effects of temperature, extracellular osmolality, and the presence of an antisickling agent (n-butylurea) on the rate of red cell oxygenation strongly suggest that the differences in oxygenation rates encountered with sickle red cells is directly related to the intracellular polymerization of deoxyhemoglobin S.
Adsorption of direct green B on mixed hydroxy-Fe-Al pillared montmorillonite with large basal spacing. (2005)

Through cation-exchanging of montmorillonite, mixed hydroxy Fe-Al-pillared montmorillonites with large basal spacing were synthesized. The application of these mixed hydroxy Fe-Al-pillared montmorillonites as adsorbents in the areas of environmental protection and pollution control was investigated. Adsorption of Direct Green B, an organic dye, on OH--Fe--, OH--Al--, OH--Fe--Al-- pillared montmorillonites was studied. Results showed that these pillared montmorillonites had much better adsorption properties than traditional Na-organo-montmorillonite. It was also found that pH of the solutions had great effect on the performance of these hydroxy-metal pillared montmorillonites in treating the wastewater containing Direct Green B.
The Immune Microenvironment Confers Resistance to MAPK Pathway Inhibitors through Macrophage-Derived TNFα (2014)

This study identifies the immune microenvironment as a source of resistance to MAPK pathway inhibitors through macrophage-derived TNFα, and reveals that in patients on treatment this source becomes reinforced. Inhibiting IκB kinase enhances the efficacy of MAPK pathway inhibitors, which identifies this approach as a potential novel strategy to improve targeted therapy in melanoma.
Influence of pulse sequence, polarity and amplitude on magnetic stimulation of human and porcine peripheral nerve (1998)

1. Mammalian phrenic nerve, in a trough filled with saline, was excited by magnetic coil (MC)-induced stimuli at defined stimulation sites, including the negative-going first spatial derivative of the induced electric field along a straight nerve, at a bend in the nerve, and at a cut nerve ending. At all such sites, the largest amplitude response for a given stimulator output setting was elicited by an induced damped polyphasic pulse consisting of an initial quarter-cycle hyperpolarization followed by a half-cycle depolarization compared with a predominantly 'monophasic' quarter-cycle depolarization. 2. Simulation studies demonstrated that the increased efficacy of the induced quarter-cycle hyperpolarizing-half-cycle depolarizing polyphasic pulse was mainly attributed to the greater duration of the outward membrane current phase, resulting in a greater outward charge transfer afforded by the half-cycle (i.e. quarter-cycles 2 and 3). The advantage of a fast rising initial quarter-cycle depolarization was more than offset by the slower rising, but longer duration depolarizing half-cycle. 3. Simulation further revealed that the quarter-cycle hyperpolarization-half-cycle depolarization showed only a 2.6 % lowering of peak outward current and a 3.5 % lowering of outward charge transfer at threshold, compared with a half-cycle depolarization alone. Presumably, this slight increase in efficacy reflects modest reversal of Na+ inactivation by the very brief initial hyperpolarization. 4. In vitro, at low bath temperature, the nerve response to an initial quarter-cycle depolarization declined in amplitude as the second hyperpolarizing phase progressively increased in amplitude and duration. This 'pull-down' phenomenon nearly disappeared as the bath temperature approached 37 C. Possibly, at the reduced temperature, delay in generation of the action potential permitted the hyperpolarization phase to reduce excitation. 5. Pull-down was not observed in the thenar muscle responses to median nerve stimulation in a normal human at normal temperature. However, pull-down emerged when the median nerve was cooled by placing ice over the forearm. 6. In a nerve at subnormal temperature straddled with non-conducting inhomogeneities, polyphasic pulses of either polarity elicited the largest responses. This was also seen when stimulating distal median nerve at normal temperature. These results imply excitation by hyperpolarizing-depolarizing pulse sequences at two separate sites. Similarly, polyphasic pulses elicited the largest responses from nerve roots and motor cortex. 7. The pull-down phenomenon has a possible clinical application in detecting pathologically slowed activation of Na+ channels. The current direction of the polyphasic waveform may become a significant factor with the increasing use of repetitive magnetic stimulators which, for technical reasons, induce a cosine-shaped half-cycle, preceded and followed by quarter-cycles of opposite polarity.
Wounding Stress Increases the Phenolic Content and Antioxidant Capacity of Purple-Flesh Potatoes (<i>Solanum tuberosum </i>L.) (2003)

Several abiotic stresses, including ethylene, methyl jasmonate, temperature, light, and wounding, were tested for their ability to induce accumulation of phenolic compounds and antioxidant capacity in purple-flesh potatoes (cv. All Blue). Results indicated that temperature, ethylene, methyl jasmonate, and light treatments did not significantly affect the accumulation of phenolic compounds compared to control samples. Only tubers with low initial anthocyanin levels treated with methyl jasmonate showed approximately 60% anthocyanin accumulation. Wounding induced the accumulation of phenolics compounds and an increase of PAL-activity in sliced tissue compared to the control. Total phenolics increased approximately 60% with a parallel 85% increase in antioxidant capacity. These results show that selection of appropriate abiotic stresses can enhance the nutritional and functional value of potatoes.
Nanoscale MOF/organosilica membranes on tubular ceramic substrates for highly selective gas separation (2017)

An efficient strategy has been developed for fabricating novel tubular MOF/organosilica nano-composite membranes with high gas separation performance.
Mutations in the extracellular domains of glutamate‐gated chloride channel α3 and β subunits from ivermectin‐resistant <i>Cooperia oncophora</i> affect agonist sensitivity (2004)

Two full-length glutamate-gated chloride channel (GluCl) cDNAs, encoding GluClalpha3 and GluClbeta subunits, were cloned from ivermectin-susceptible (IVS) and -resistant (IVR) Cooperia oncophora adult worms. The IVS and IVR GluClalpha3 subunits differ at three amino acid positions, while the IVS and IVR GluClbeta subunits differ at two amino acid positions. The aim of this study was to determine whether mutations in the IVR subunits affect agonist sensitivity. The subunits were expressed singly and in combination in Xenopus laevis oocytes. Electrophysiological whole-cell voltage-clamp recordings showed that mutations in the IVR GluClalpha3 caused a modest but significant threefold loss of sensitivity to glutamate, the natural ligand for GluCl receptors. As well, a significant decrease in sensitivity to the anthelmintics ivermectin and moxidectin was observed in the IVR GluClalpha3 receptor. Mutations in the IVR GluClbeta subunit abolished glutamate sensitivity. Co-expressing the IVS GluClalpha3 and GluClbeta subunits resulted in heteromeric channels that were more sensitive to glutamate than the respective homomeric channels, demonstrating co-assembly of the subunits. In contrast, the heteromeric IVR channels were less sensitive to glutamate than the homomeric IVR GluClalpha3 channels. The heteromeric IVS channels were significantly more sensitive to glutamate than the heteromeric IVR channels. Of the three amino acids distinguishing the IVS and IVR GluClalpha3 subunits, only one of them, L256F, accounted for the differences in response between the IVS and IVR GluClalpha3 homomeric channels.
TSV Technology and High-Energy Heavy Ions Radiation Impact Review (2018)

Three-dimensional integrated circuits (3D IC) based on TSV (Through Silicon Via) technology is the latest packaging technology with the smallest size and quality. As a result, it can effectively reduce parasitic effects, improve work efficiency, reduce the power consumption of the chip, and so on. TSV-based silicon interposers have been applied in the ground environment. In order to meet the miniaturization, high performance and low-cost requirements of aerospace equipment, the adapter substrate is a better choice. However, the transfer substrate, as an important part of 3D integrated circuits, may accumulate charge due to heavy ion irradiation and further reduce the performance of the entire chip package in harsh space radiation environment or cause it to fail completely. Little research has been carried out until now. This article summarizes the research methods and conclusions of the research on silicon interposers and TSV technology in recent years, as well as the influence of high-energy heavy ions on semiconductor devices. Based on this, a series of research methods to study the effect of high-energy heavy ions on TSV and silicon adapter plates is proposed.
Fiber texturing in nano-crystalline TiO<sub>2</sub> thin films deposited at 150 °C by dc-reactive sputtering on fiber-textured [0 0 0 1] ZnO : Al substrates (2012)

Abstract TiO 2 thin films were deposited at an effective surface temperature of 150 °C by dc-reactive magnetron sputtering on ZnO : Al oriented substrates having a fiber texture along the [0 0 0 1] axis, and studied by transmission electron microscopy and x-ray diffraction analyses. The substrate texturing was used to tailor the TiO 2 structure in such a way that a porous matrix made of anatase nano-grains (10 nm in diameter) is formed instead of an amorphous layer (as observed at 150 °C on glass). Additionally, we demonstrate that, by adding an ex situ 200 °C annealing, the anatase domains also gain a fiber texture with the axes aligned to that of the substrate. The TiO 2 /AZO structural coupling is expected to play a crucial role for the carrier transport through the interface as required in dye-sensitized solar cells. Moreover, the low temperatures used render the process compatible with commonly used plastics substrates.