gebhart/patrepeval huggingface dataset:
Abstract 16948: Local Low Endothelial Shear Stress (ESS) Provides Incremental Prediction of Non-culprit MACE in Addition to Plaque Burden, Minimal Lumen Area, and Plaque Morphology: The PROSPECT Study (2015)

Introduction: Low ESS, a pro-inflammatory stimulus, is an important predictor of coronary plaque development/progression. Whether low ESS adds incremental predictive value for future major adverse cardiac events (MACE) in untreated coronary lesions in high-risk patients with an acute coronary syndrome (ACS) is unknown. Methods: In the PROSPECT study, 697 patients with ACS underwent 3-vessel intracoronary imaging. Independent predictors of non-culprit (nc) lesion MACE from untreated coronary lesions in 3 year followup (f/u) were large plaque burden (PB), small minimum lumen area (MLA), and thin cap fibroatheroma (TCFA) morphology. In the present analysis, all nc-lesions leading to a new MACE in f/u (nc-MACE lesions, n=50) and ~4-fold randomly selected control nc-lesions without f/u MACE (nc-non-MACE lesions) were analyzed. Baseline ESS for each lesion was calculated using computational fluid dynamics. A propensity score for low ESS was determined accounting for PB, MLA, TCFA, artery and location in the artery. Local ESS (lowest ESS in 90 o arc around the artery) was then examined for incremental association with MACE. Results: Imaging was sufficient for analysis in 32 nc-MACE lesions. Two nc-MACE lesions were excluded due to unreliable lesion morphology. Non-fibroatheromas were too few for analysis and excluded. Final dataset included 145 lesions: 13 nc-MACE TCFA, 10 nc-MACE thick cap fibroatheroma (ThCFA), and 122 non-nc-MACE lesions (63 TCFA, 59 ThCFA). Cumulative frequency distribution shows lesions responsible for future nc-MACE frequently exhibited low ESS (Figure). In a propensity-adjusted multivariable model, low ESS was strongly associated with nc-MACE in f/u (odds ratio 0.16 [95% CI 0.06-0.40], p<0.0001). Conclusions: After accounting for large PB, small MLA, TCFA, and lesion location, low local ESS adds significant and substantial incremental predictive value to identify high-risk untreated lesions likely to cause MACE during 3 year followup.
Patient Empowerment through Personal Medical Recommendations (2015)

Patients today have ample opportunities to inform themselves about their disease and possible treatments using the Internet. While this type of patient empowerment is widely regarded as having a positive influence on the treatment, there exists the problem that the quality of information that can be found on online is very diverse. This paper presents a platform which empowers patients by allowing searching in a high quality document repository. In addition, it automatically provides intelligent and personalized recommendations according to the individual preferences and medical conditions.
Statistical and scientific databases (1991)

Statistical/scientific database management user interfaces physical database support data models data analysis systems statistical query languages query optimization precision in processing queries data security statistical expert systems geographically organized data object-oriented approaches.
Electronic Structure of Protonic Conductor SrTi<sub>0.98</sub>Sc<sub>0.02</sub>O<sub>3</sub> Probed by Soft-X-ray Spectroscopy (2005)

The electronic structure of a protonic conductor Sc-doped SrTiO 3 (SrTi 0.98 Sc 0.02 O 3 ) single crystal has been studied by photoemission spectroscopy and X-ray absorption spectroscopy. The holes and acceptor level are observed at the top of the valence band and just above the Fermi level ( E F ), respectively, in dried SrTi 0.98 Sc 0.02 O 3 . Their intensities are lower in H 2 -annealed SrTi 0.98 Sc 0.02 O 3 . The E F of H 2 -annealed SrTi 0.98 Sc 0.02 O 3 shifts to the conduction band side by approximately 0.4 eV compared with that of a dried sample. These findings indicate that the doped hydrogen compensates the existence of the holes.
Hydro-geological Conditions and Mine Inflow Water Forecast of the Western Long Beach in Junggar Coalfield (2012)

Gushing water is harmful to underground coal mine safety. Jungar coalfield is the major coal base in the Chinese Midwest, and coal-bearing strata are mainly Shanxi Formation and Taiyuan Formation. Coal seams can be mined in the western long beach are 3#, 5#, 6#, 9#. This paper analyzed regional geological conditions, hydro-geological conditions in the western Long Beach of Jungar coalfield, and water-filled factors, predicted mine water discharge, based on the prediction, and proposed prevention and treatment measures of coal mine water.
Random Serum Cortisol as a Predictor for Survival of Terminally Ill Patients With Cancer (2014)

Although previous research found that serum cortisol levels were associated with cancer prognosis, it is unclear whether this association remains robust even at the very end of life of patients with cancer. We conducted a retrospective chart review of 125 patients with terminal cancer to investigate the role of random serum cortisol levels in predicting the remaining life expectancy. The high random cortisol group had a significantly shorter survival time than the low random cortisol group (7.5 vs 26 days). After adjusting for potential confounders, key factors such as poor performance status, hypoalbuminemia, and high random cortisol level are associated with poor survival. Our results suggest that the random serum cortisol level is an independent predictor of survival time of patients with terminally ill cancer.
Fibroblast Growth Factor 23 Predicts Left Ventricular Mass and Induces Cell Adhesion Molecule Formation (2011)

Elevated FGF-23 is a predictor of mortality and is associated with LVH in CKD. It may be a biomarker or a direct toxin. We assessed the relationship between FGF-23 and LVH in CKD using CMRI. In vitro we studied the effect of phosphate, FGF-23, and Klotho on E-selectin and VCAM production in HUVECs. FGF-23 concentration correlates negatively with eGFR and positively with LVMI. FGF-23 was an independent predictor of LVH in CKD. E-selectin and VCAM production was elevated in HUVECs cultured in high phosphate with FGF-23 or Klotho. This effect was attenuated in cells exposed to both FGF-23 and Klotho. FGF-23 is an independent predictor of LVH as measured by CMRI. We show preliminary data which supports that FGF-23 is toxic resulting in activation of the vascular endothelium. We do not prove causality with elevated FGF-23 and LVH. Further research should ascertain if lowering levels of FGF-23 translates to improved clinical outcomes.
Protein refolding in predominantly organic media markedly enhanced by common salts (1999)

The refolding/reoxidation of unfolded/reduced hen egg-white lysozyme was investigated in a variety of predominantly nonaqueous media consisting of protein-dissolving organic solvents and water. It was discovered that LiCl and other common salts dramatically (up to more than 100-fold) increased the refolding yield of lysozyme in such nonaqueous systems, while reducing it in water. The mechanism of this surprising phenomenon appears to involve salt-induced suppression of nonspecific lysozyme aggregation during refolding due to an enhanced protein solubility. © 1999 John Wiley & Sons, Inc. Biotechnol Bioeng 62: 704–710, 1999.
The family of the interleukin‐1 receptors (2017)

The extracellular forms of the IL-1 cytokines are active through binding to specific receptors on the surface of target cells. IL-1 ligands bind to the extracellular portion of their ligand-binding receptor chain. For signaling to take place, a non-binding accessory chain is recruited into a heterotrimeric complex. The intracellular approximation of the Toll-IL-1-receptor (TIR) domains of the 2 receptor chains is the event that initiates signaling. The family of IL-1 receptors (IL-1R) includes 10 structurally related members, and the distantly related soluble protein IL-18BP that acts as inhibitor of the cytokine IL-18. Over the years the receptors of the IL-1 family have been known with many different names, with significant confusion. Thus, we will use here a recently proposed unifying nomenclature. The family includes several ligand-binding chains (IL-1R1, IL-1R2, IL-1R4, IL-1R5, and IL-1R6), 2 types of accessory chains (IL-1R3, IL-1R7), molecules that act as inhibitors of signaling (IL-1R2, IL-1R8, IL-18BP), and 2 orphan receptors (IL-1R9, IL-1R10). In this review, we will examine how the receptors of the IL-1 family regulate the inflammatory and anti-inflammatory functions of the IL-1 cytokines and are, more at large, involved in modulating defensive and pathological innate immunity and inflammation. Regulation of the IL-1/IL-1R system in the brain will be also described, as an example of the peculiarities of organ-specific modulation of inflammation.
Two‐component interpenetrating polymer networks (IPNs) from polyurethanes and epoxies. I. Studies on full IPN, pseudo‐IPN, and graft polymer alloys of polyurethanes and epoxies (1984)

Abstract In this article we review the synthesis and morphology and the physical and mechanical properties of two‐component interpenetrating polymer networks (IPNs) from polyurethane and epoxy polymers; the corresponding pseudo‐IPNs and grafted IPNs are also discussed. A comparison was made of full IPNs, pseudo‐IPNs, grafted IPNs, and related homopolymers by examining their mechanical properties, mechanical spectra, and electron microscopy on an investigation of the effects of interpenetration or permanent entanglement in the IPN and related systems. This interpenetration has resulted in improved compatibility between the two polymer systems and has caused a decrease in the degree of phase separation. An observed shift in the dynamic glass transition temperatures ( T g s) of the two components which yielded a single IPN T g further substantiates our results.
Gene cloning, expression, and characterization of a beta-agarase, agaB34,from Agarivorans albus YKW-34. (2009)

A beta-agarase gene, agaB34, was functionally cloned from the genomic DNA of a marine bacterium, Agarivorans albus YKW-34. The open reading frame of agaB34 consisted of 1,362 bp encoding 453 amino acids. The deduced amino acid sequence, consisting of a typical N-terminal signal peptide followed by a catalytic domain of glycoside hydrolase family 16 (GH-16) and a carbohydrate-binding module (CBM), showed 37-86% identity to those of agarases belonging to family GH-16. The recombinant enzyme (rAgaB34) with a molecular mass of 49 kDa was produced extracellularly using Escherichia coli DH5alpha as a host. The purified rAgaB34 was a beta-agarase yielding neoagarotetraose (NA4) as the main product. It acted on neoagarohexaose to produce NA4 and neoagarobiose, but it could not further degrade NA4. The maximal activity of rAgaB34 was observed at 30 degrees and pH 7.0. It was stable over pH 5.0-9.0 and at temperatures up to 50 degrees . Its specific activity and kcat/Km value for agarose were 242 U/mg and 1.7x106/sM, respectively. The activity of rAgaB34 was not affected by metal ions commonly existing in seawater. It was resistant to chelating reagents (EDTA, EGTA), reducing reagents (DTT, beta-mercaptoethanol), and denaturing reagents (SDS and urea). The E. coli cell harboring the pUC18-derived agarase expression vector was able to efficiently excrete agarase into the culture medium. Hence, this expression system might be used to express secretory proteins.
A wideband heterodyne optical phase-locked loop for generation of 3-18 GHz microwave carriers (1992)

Experimental results of a wideband heterodyne second-order optical phase-locked loop with 1.5- mu m semiconductor lasers are presented. The loop has a bandwidth of 180 MHz, a gain of 181 dBHz, and a propagation delay of only 400 ps. A beat signal of 8 MHz linewidth is phase locked to become a replica of a microwave reference source close to carrier with a noise level of -125 dBc/Hz. The total phase variance of the locked carrier is 0.04 rad/sup 2/ and carriers can be generated in a continuous range from 3 to 18 GHz. The loop reliability is excellent with an average time to cycle slip of 10/sup 11/ s and an acquisition range of 640 MHz.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Evidence for the Association of Cytomegalovirus with Carcinoma of the Prostate (1977)

A human genital isolate of cytomegalovirus is shown to have transformed human embryonic lung cells in vitro. These cells produce tumors when injected into athymic nude mice. Two cell lines derived from tissue from human prostatic carcinoma have survived more than 20 passages in vitro and demonstrate cytomegalovirus-specific membrane antigen. Significant humoral antibody titers against cytomegalovirus have been demonstrated. Cell-mediated lymphocytotoxicity against these transformed cells has been demonstrated in patients with urinary tract tumors. This evidence indicates that an association between cytomegalovirus and human prostatic cancer may be more than coincidental.
Pipeline muffling and a priori current ramping: architectural techniques to reduce high-frequency inductive noise (2003)

While circuit and package designers have addressed microprocessor inductive noise issues in the past, multi-gigahertz clock frequencies and billion-transistor-level integration are exacerbating the problem, necessitating microarchitectural solutions. The large net on-die decoupling capacitance used to address this noise throughout the chip consumes substantial area and can cause a large leakage current. This paper proposes microarchitectural techniques to reduce high-frequency current variability, reducing the need for decoupling capacitors. We observe that we can control inductive noise by reducing current variability either in space (i.e., variability in usage of circuit blocks) or in time (i.e., variability within a circuit block across clock cycles). We propose pipeline muffling, a novel technique to reduce changes in the number of resources being utilized by controlling instruction issue, trading off some energy and performance to control di/dt in space. We also extend a previous technique, which incurs performance and energy degradation, and propose a priori current ramping to allow the current of a resource to ramp up ahead of usage, with virtually no performance loss, and ramp down immediately after usage, with little energy loss. Our techniques guarantee a worst-case bound on the di/dt, which is required to reduce the demand for decoupling capacitors, saving area and reducing leakage.
Law enforcement and mobile communications (1996)

This paper discusses the problems of legal interception on mobile communications systems and outlines the cooperation that law enforcement agencies are expecting from operators, service providers and equipment manufacturers. The advantages for business and social life provided by mobile communications are enormous. Unfortunately, there is evidence that organised crime and terrorism migrate to systems that they perceive as providing the most secure communications. Within the European Union, and in conjunction with some other developed countries, work is going on to ensure that interception facilities are retained even though the GSM roaming and, shortly, satellite systems will be able to offer service from outside national boundaries. This subject, along with that of encryption on telecommunications systems, sometime raises strong passions in the area of privacy and human rights. (5 pages)
Epikeratophakia: The surgical correction of aphakia. II. Preliminary results in a non-human primate model (1981)

AbstractWe have developed a new form of refractive surgery, epikeratophakia, in which a disc of donor corneal tissue is lathed to a specific dioptric power and sutured on top of the recipient's cornea after the recipient epithelium has been removed. The optical correction obtained with epikeratophakia should be similar in quality to that of a contact lens, but would be permanent and would require no maintenance.A non-human primate model was used to test the predictability, stability, and clarity of epikeratophakia grafts. After surgery, the grafts did not always re-epithelialize readily; this problem has been solved with the use of a small, steep, soft bandage contact lens. For the nine month period of this study, the epikeratophakia grafts have remained clear and the curvatures of the anterior surfaces have remained constant. However, the actual visual potential of these grafts can be evaluated only by a controlled clinical study in humans.
Chirurgie de l'artère carotide interne par greffe veineuse (1994)

L'endarteriectomie est le seul procede conventionnellement retenu pour traiter une stenose atherosclereuse de la carotide interne, mais elle comporte des ecueils: difficultes de realisation ou echecs dans certaines situations lesionnelles, restenose precoce par hyperplasie myo-intimale ou restenose secondaire atherosclereuse. La greffe veineuse represente une alternative soit lorsque l'endarteriectomie apparait en peroperatoire difficile, aleatoire ou s'est accompagnee d'un traumatisme parietal, soit lorsque la diffusion des lesions atherosclereuses augmente le risque de complications precoces ou secondaires, soit lorsque l'endarteriectomie doit etre associee a la cure d'une boucle ou d'une dysplasie sus-jacente. La greffe veineuse evite les aleas techniques de l'endarteriectomie
MNDO study of boron-nitrogen analogs of buckminsterfullerene (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMNDO study of boron-nitrogen analogs of buckminsterfullereneXinfu Xia, Daniel A. Jelski, James R. Bowser, and Thomas F. GeorgeCite this: J. Am. Chem. Soc. 1992, 114, 16, 6493–6496Publication Date (Print):July 1, 1992Publication History Published online1 May 2002Published inissue 1 July 1992https://pubs.acs.org/doi/10.1021/ja00042a032https://doi.org/10.1021/ja00042a032research-articleACS PublicationsRequest reuse permissionsArticle Views249Altmetric-Citations91LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Modified spectral subtraction for de-noising heart sounds: Interference Suppression via Spectral Comparison (2008)

Heart disease remains the leading cause of fatalities in the western world. To address this many long-term systems have been developed including heart sound monitors or phonocardiograms (PCG). In daily life ambient acoustic noise interferes with the heart sound signal. This noise must be suppressed to allow effective monitoring of heart function. This paper proposes a new 2-channel signal processing technique, termed interference suppression via spectral comparison (ISSC) which is based on the 1-channel spectral subtraction algorithm, and aims at improving the quality of the recorded heart sound or PCG data. The proposed technique provides the best overall quality improvement when applied to six different heart sounds when compared to other noise cancellation algorithms namely: simple subtraction, adaptive least mean squares (LMS) and recursive least squares (RLS) filter and wavelet thresholding.
Innovative Use of Kaolinite in Downhole Scale Management: Squeeze-Life Enhancement and Water Shutoff (2009)

Summary Applied research has been undertaken to examine the potential of kaolinite combined with a kaolinite-fixation agent to increase squeeze lifetime through alteration of near-wellbore surface characteristics and mineralogy, and to provide water-shutoff control. With respect to enhancing squeeze lifetime, it is documented that kaolinite increases the quantity of inhibitor adsorbed. Conversely, clean sandstone with low clay content commonly provides a poor substrate for adsorption. Furthermore, in reservoirs that experience near-wellbore formation damage because of kaolinite mobilization, it has been shown that the use of a fixation agent as part of a squeeze treatment can increase squeeze lifetime. Using these facts, research has assessed the feasibility of injecting micro-crystalline kaolinite (average particle size 2 μm) combined with the fixation agent and scale inhibitor as a means of mechanically altering near-wellbore mineralogy and surface-property characteristics within clean, high-permeability sandstones. The testing has been designed to mimic the squeeze procedure used in the field for performing such a job and involves no additional steps to those used in a normal squeeze (i.e., preflush, main treatment, overflush). The paper presents the results of coreflood experiments that demonstrate "proof of concept," along with examples of potential field applications. A further concept, born from the initial idea, was the use of kaolinite and fixation agent for efficient, low-cost, environmentally friendly water shutoff. There are several available products for water shutoff, but the disadvantage of these is that they are not acceptable for use in Norway because of poor environmental characteristics. Hence, there was a need to fill this gap by developing water-shutoff technology to meet country-specific environmental legislation. The paper provides details of coreflood testing where an excess of kaolinite has been used to form an internal and external filter cake that is attached to the wellbore face and within the near-wellbore region using the fixation agent. The paper draws on data from StatoilHydro-operated fields in order to highlight the potential of this innovative approach to downhole scale management and water control.
Clinical Pharmacokinetics of Irinotecan and Its Metabolites: A Population Analysis (2002)

Plasma data of CPT-11 and metabolites could be adequately described by this compartmental model, which may be useful in predicting the time courses, including interindividual variability, of all characterized substances after intravenous administrations of CPT-11.
Variation in <i>TCF7L2</i> Influences Therapeutic Response to Sulfonylureas (2007)

TCF7L2 variants influence therapeutic response to sulfonylureas but not metformin. This study establishes that genetic variation can alter response to therapy in type 2 diabetes.
Chemical composition of essential oil of <i>Calendula officinalis</i> L. (pot marigold) (1991)

Abstract The essential oil of Calendula officinalis L. was obtained in low yield (0.3 %) by steam distillation with cohobation from flowers and whole plants. Sixty‐six components were identified by GC‐MS, mainly sesquiterpene alcohols: α‐cadinol was the main constituent (about 25%). The essential oil from the whole plant differed from that of the flowers by the presence of monoterpene hydrocarbons in addition to the alcohols.