gebhart/patrepeval huggingface dataset:
Chronic motor cortex stimulation for movement disorders: A promising perspective (2003)

Five patients affected by thalamic hand and international myoclonus have been evaluated and selected for chronic motor cortex stimulation. A quadripolar electrode strip was placed epidurally under local anesthesia through an MR-image-guided single precentral burr hole placed following the morphologic recognition of the central sulcus. Intra-operative stimulation was used to induce muscle contraction at the affected site to confirm the correct placement of the electrode. A one-week trial period preceded the implant of an internal pace-maker under general anesthesia. A remarkable decrease in pain was reported by four patients together with the reduction of dystonia and rigidity in thalamic hand and marked decrease of intentional myoclonus. No complications or undesired side effects of electrode implant and stimulation were observed.
Variability of the body surface distributions of QRS, ST-T and QRST deflection areas with varied activation sequence in dogs (1980)

Distributions of QRS, ST-T and QRST areas of 192 lead body surface ECG's were measured in dogs for multiple activation orders. Qualitatively, the distributions of QRST area were found to be strikingly similar over all activation orders in contrast to the distributions of QRS or ST-T areas. Quantitative results showed that variability of the QRST areas over all activation orders was consistently less than those of either QRS or ST-T. The factor responsible for the QRS deflection is ventricular activation sequence while those responsible for the ST-T deflection are both activation sequence and ventricular recovery properties. Since the total QRST deflection area was largely independent of activation sequence it is likely the quantity is an index of ventricular recovery properties. The significance of this relation is that QRST deflection area may permit evaluation of intrinsic ventricular recovery properties in the presence of abnormal ventricular activation as occurs with intraventricular conduction disorders and ectopic origin of excitation. Evaluation of intrinsic ventricular recovery properties may also permit recognition of states at risk of ventricular arrhythmias due to increased disparity of these properties.
Observation of multiple-valued attractors and crises in a driven nonlinear circuit (1983)

The attractor of the chaos in a driven nonlinear dissipative circuit is observed. The attractor is made of a curve imperfectly folded many times. The crisis effect, the sudden onset of chaos caused by the collision of the subband attractor with the unstable periodic orbit, is verified experimentally.
alpha-latrotoxin of black widow spider venom depolarizes the plasma membrane, induces massive calcium influx, and stimulates transmitter release in guinea pig brain synaptosomes. (1982)

The effect of alpha-latrotoxin from black widow spider venom upon guinea pig cerebral cortical synaptosomes is described. Plasma membrane potential (delta psi p), in situ mitochondrial membrane potential (delta psi m), Ca2+ transport, gamma-amino[3H]butyrate release, [3H]noradrenaline release, and synaptosomal ATP were monitored under parallel conditions. Potentials were determined both isotopically and with a tetraphenylphosphonium-selective electrode. alpha-Latrotoxin depolarizes delta psi p selectively, both in the presence and absence of Ca2+. A slight toxin-induced depolarization of delta psi m is a consequence of a massive Ca2+ uptake across the plasma membrane. Depolarization of delta psi p is insensitive to tetrodotoxin, and Ca2+ entry is only partially inhibited by verapamil. Release of [3H]noradrenaline and gamma-amino[3H]butyrate is markedly stimulated by the toxin in the presence of Ca2+, and this effect is only slightly reduced in Ca2+-free conditions.
Troponin I Degradation and Covalent Complex Formation Accompanies Myocardial Ischemia/Reperfusion Injury (1999)

Selective troponin I (TnI) modification has been demonstrated to be in part responsible for the contractile dysfunction observed with myocardial ischemia/reperfusion injury. We have isolated and characterized modified TnI products in isolated rat hearts after 0, 15, or 60 minutes of ischemia followed by 45 minutes of reperfusion using affinity chromatography with cardiac troponin C (TnC) and an anti-TnI antibody, immunological mapping, reversed-phase high-performance liquid chromatography, and mass spectrometry. Rat cardiac TnI becomes progressively degraded from 210 amino acid residues to residues 1-193, 63-193, and 73-193 with increased severity of injury. Degradation is accompanied by formation of covalent complexes between TnI 1-193 and, respectively, TnC residues 1-94 and troponin T (TnT) residues 191-298. The covalent complexes are likely a result of isopeptide bond formation between lysine 193 of TnI and glutamine 191 of TnT by the cross-linking enzyme transglutaminase. With severe ischemia, cellular necrosis results in specific release of TnI 1-193 into the reperfusion effluent and TnT degradation in the myocardium (25-, 27-, and 33-kDa products). Two-dimensional electrophoresis demonstrated that phosphorylation of TnI prevents ischemia-induced degradation. This study characterized the modified TnI products in isolated rat hearts reperfused after a brief or severe period of ischemia, revealing the progressive nature of TnI degradation, changes in phosphorylation, and covalent complexes with ischemia/reperfusion injury. Finally, we propose a model for ischemia/reperfusion injury in which the extent of proteolytic and transglutaminase activities ultimately determines whether apoptosis or necrosis is achieved.
Specific interaction of TFII‐I with an upstream element on the HIV‐1 LTR regulates induction of latent provirus (2008)

RBF-2 is a factor comprised of a USF1/2 heterodimer, whose association with a highly conserved upstream element (RBEIII) on the HIV-1 LTR requires a co-factor TFII-I. We have identified specific nucleotides, immediately 3' of RBEIII that are required for stable association of TFII-I with this region of the LTR. Mutations that inhibit interaction of TFII-I with DNA also prevent stimulation of USF binding to RBEIII, and render the integrated LTR unresponsive to T cell signaling. These results demonstrate an essential role of TFII-I bound at an upstream LTR element for viral replication.
Synchrotron light as a source for extreme ultraviolet lithography (1999)

In August 1998 a new European research program named Extreme Ultraviolet Concept Lithography Development System (EUCLIDES) was started. The program headed by ASM Lithography (ASML), partnered by Carl Zeiss and Oxford Instruments is evaluating extreme ultraviolet (EUV) light as a viable lithographic solution for resolutions of 70 nm and below. Oxford Instruments has investigated various options to use as synchrotron light sources: bending magnets, undulators, and wigglers. Output characteristics are given in terms of angular distribution and power spectrum. It will be explained wigglers are the preferred synchrotron light. The outline design of the storage ring is presented. The lattice is reviewed together with the light output properties and space requirements. How these drive the cost of ownership is addressed. Finally a brief comparison is made between this and the alternative (laser plasma) sources for EUV.
Enhanced depth of field integral imaging with sensor resolution constraints (2004)

One of the main challenges in integral imaging is to overcome the limited depth of field. Although it is widely assumed that such limitation is mainly imposed by diffraction due to lenslet imaging, we show that the most restricting factor is the pixelated structure of the sensor (CCD). In this context, we demonstrate that by proper reduction of the fill factor of pickup microlenses, the depth of field can be substantially improved with no deterioration of lateral resolution.
Photochemotherapy of Psoriasis (1976)

Psoralens have been used for decades to stimulate repigmentation in cases of vitiligo. Recently, there has been considerable interest in the treatment of psoriasis with orally administered psoralens and subsequent exposure to longwave ultraviolet light (UVA, 320 to 400 nm). The relationship between the responses of these skin diseases to psoralen therapy and the striking erythemogenic and melanogenic effects of photoactive psoralens on normal skin is unknown. No relationship has yet been established between any of these cutaneous effects and the known formation of photoadducts of thymine and psoralen, nor between cutaneous effects of psoralen therapy and the transiently decreased DNA synthesis that occurs when psoralentreated cells are exposed to UVA. Double-blind acute toxicity studies performed on human volunteers and studies of large numbers of vitiligo cases have disproved the early concerns about the possible hepatotoxicity of psoralens. Repeated exposure to high doses of UVA is carcinogenic to certain laboratory
[Influence of the procedure of administration in the activity of some antidepressant or disinhibiting drugs upon behavioural despair (author's transl)]. (1981)

Imipramine, doxepin, mianserin, pipotiazine and sulpiride, all active upon behavioural despair test of Porsolt and coll. in unique administration, are devoid of activity, with the exception of mianserin and sulpiride, in repetitive administration. It would be possible that a diminution of cerebral levels of neurotransmitters NA and DA after repetitive administration of imipramine, doxepin and pipotiazine (or an over-sensitivity to serotonin in the case of imipramine and doxepin) and an increase of these levels after repetitive administration of mianserin and sulpiride (with an antiserotonin activity for mianserin) would be responsible for these discrepancies.
Immediate Influence of Transcranial Electrostimulation on Pain and β-Endorphin Blood Levels (2003)

Transcranial electrostimulation is a nonpharmacologic method of pain relief accompanied or mediated by beta-endorphin release. The comparable degree of the initial clinical response emphasizes the powerful placebo effect on reported pain not mediated by endorphin release. This preliminary study shows that noninvasive electrical stimulation is a safe treatment with a positive effect on beta-endorphin blood levels.
Preparation and Properties of Hexaaryldisilanes (1951)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation and Properties of HexaaryldisilanesHenry Gilman and G. E. DunnCite this: J. Am. Chem. Soc. 1951, 73, 11, 5077–5079Publication Date (Print):November 1, 1951Publication History Published online1 May 2002Published inissue 1 November 1951https://pubs.acs.org/doi/10.1021/ja01155a016https://doi.org/10.1021/ja01155a016research-articleACS PublicationsRequest reuse permissionsArticle Views444Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Properties of Non-Neurovirulent Plaque-Forming Mutants of Newcastle Disease Virus (1976)

The mesogenic Hertfordshire (H) strain, a vaccine strain of Newcastle disease virus, represents a heterogeneous virus population differing in physical, chemical, and biological properties. Small (S) and large (L) plaque-forming mutants were isolted from strain H in chick embryo fibroblast cell cultures. Part of the S mutants lacked neurovirulence, with an intracerebral pathogenicity index for day-old chicks of 0 to 0.46 vs 1.0 to 1.4 for L mutants. S mutants grew only to a very low titer in the brain of day-old chicks and cleared from the brain by the sixth day, whereas L mutants killed the chicks after a 1000-fold titer rise. The S mutants caused a complete cell destruction in fibroblast culture by 12 hours, but they had 10--20 times lower virus yields than the L mutants. The infective titers of S and L mutants grown in allantoic cells were identical, but the infectivity to hemagglutinin ratio was 10 to 50 times lower for S than for L. The thermostability of infectivity and hemagglutinin varied with the different mutants. As for the immunogenicity of the mutants, the minimum dose of S mutants inducing full protection by subcutaneous inoculation was 10(6) plaque-forming units per chicken, thus being about 100 times less immunogenic than either the L mutants or the parent strain H.
Enantioselective Hydrogenation of α-Aryloxy α,β-Unsaturated Acids. Asymmetric Synthesis of α-Aryloxycarboxylic Acids (2004)

[reaction: see text] A facile preparation of chiral alpha-aryloxy carboxylic acids via asymmetric hydrogenation of the corresponding unsaturated acids has been discovered. A number of catalysts have been identified that give high product enantioselectivity, and the scope of the reaction has been examined with respect to substitution on the aromatic ring and olefin.
A soy‐derived antiapoptotic fraction decreases methotrexate toxicity in the gastrointestinal tract of the rat (1997)

The ability of a soy-derived antiapoptotic fraction to inhibit methotrexate-induced gastrointestinal toxicity was examined. Male Sprague-Dawley rats treated with methotrexate were fed diets containing casein as a sole protein source or diets supplemented with a protein-phospholipid fraction isolated from soy flour. This soy fraction has also been shown to inhibit serum deprivation-induced programmed cell death (apoptosis) in the mouse embryonic C3H10T1/2 cell. Rats that received high doses of the soy-derived antiapoptotic fraction-supplemented diets experienced significantly less weight loss and diarrhea and better maintained their pretreatment appetite.
Transformations of 6-Phenyl-1,2,4-triazine 4-Oxides in Reactions with Nucleophiles (1995)

Reaction of 6-phenyl-1,2,4-triazine 4-oxide 1a with 1,3-dimethyluracil-6-hydrazones 2a–c in dimethylformamide in the presence of triethylamine affords the pyrazolo[3,4-d]pyrimidines 3a–c; under similar conditions 1,2,4-triazine 4-oxide 1b reacts with 1-phenyl-3-methylpyrazolone 7 to give the hydrazone derivative 8 and the dipyrazolylmethane derivative 9.
Transglutaminase activity of cultured human prostatic epithelium. (1980)

A transglutaminase was extracted from cultured human prostatic adenocarcinoma cells. The enzyme did not exist as a zymogen and had an apparent molecular weight of 72,000 +/- 4,000 by gel filtration. Although the role of this transglutaminase in the human prostate is uncertain, it may be a useful marker for prostatic cells in vitro.
Exacerbation of psoriasis by ibuprofen. (1986)

We describe a patient whose cutaneous manifestations of psoriatic arthritis were exacerbated while she was treated with ibuprofen. Discontinuation of the medication resulted in immediate improvement of the skin lesions. Reappearance of the joint symptoms prompted the patient to take ibuprofen again, after which she experienced a flare of new psoriatic plaques.
Precise, absolute earthquake location under Somma-Vesuvius volcano using a new three-dimensional velocity model (2001)

The Somma–Vesuvius volcanic complex and surroundings are characterized by topographic relief of over 1000 m and strong 3-D structural variations. This complexity has to be taken into account when monitoring the background volcano seismicity in order to obtain reliable estimates of the absolute epicentres, depths and focal mechanisms for events beneath the volcano. We have developed a 3-D P-wave velocity model for Vesuvius by interpolation of 2-D velocity sections obtained from non-linear tomographic inversion of the Tomoves 1994 and 1996 active seismic experiment data. The comparison of predicted and observed 3-D traveltime data from active and passive seismic data validate the 3-D interpolated model. We have relocated about 400 natural seismic events from 1989 to 1998 under Vesuvius using the new interpolated 3-D model with two different VP/VS ratios and a global search, 3-D location method. The solution quality, station residuals and hypocentre distribution for these 3-D locations have been compared with those for a representative layered model. A relatively high VP/VS ratio of 1.90 has been obtained. The highest-quality set of locations using the new 3-D model falls in a depth range of about 1–3.5 km below sea level, significantly shallower than the 2–6 km event depths determined in previous studies. The events are concentrated in the upper 2 km of the Mesozoic carbonate basement underlying the Somma–Vesuvius complex. The first-motion mechanisms for a subset of these events, although highly variable, give a weak indication of predominantly N–S to near-vertical directions for the tension axes, and ESE–WNW near-vertical directions for the compression axes.
Near Point of Convergence After a Sport-Related Concussion (2015)

CI was common (~42%) in athletes evaluated within 1 month after an SRC. Athletes with CI had worse neurocognitive impairment and higher symptom scores than did those with normal NPC. Clinicians should consider routinely screening for NPC as part of a comprehensive concussion evaluation to help inform treatment recommendations, academic accommodations, and referrals for vision therapy.
Psychometric properties of the Dimensions of Stressful Events Rating Scale. (2008)

Unlike other instruments designed to assess DSM-IV Criterion A for posttraumatic stress disorder, exposure to a high-magnitude stressor, the Dimensions of Stressful Events (DOSE) scale assesses not...
Hyperopia is predominantly axial in nature (1998)

Our results suggest that hyperopia, like myopia, is predominantly axial in nature, although the corneal radius also plays a role in determining refractive error magnitude. These results have implications for refractive surgery and visual performance in hyperopic eyes.
Synthesis and some reactions of 4-bromoimidazole-5-sulfonyl derivatives. A reinvestigation (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and some reactions of 4-bromoimidazole-5-sulfonyl derivatives. A reinvestigationHeinz Kropf and Felix WoehrleCite this: J. Chem. Eng. Data 1988, 33, 4, 537–538Publication Date (Print):October 1, 1988Publication History Published online1 May 2002Published inissue 1 October 1988https://pubs.acs.org/doi/10.1021/je00054a043https://doi.org/10.1021/je00054a043research-articleACS PublicationsRequest reuse permissionsArticle Views126Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Gnostic Illusion: Problematic Realized Eschatology in <i>The Matrix Reloaded</i> (2003)

While a Gnostic interpretation of The Matrix illuminates that film’s presentation of enlightenment and salvation, the sequel The Matrix Reloaded takes the inadequacy of the Gnostic worldview as one of its themes. The community of the enlightened is revealed to be in the thrall of dangerous illusions, and its saviour, who is effective only within the unreal world, lends paradoxical gravity to the discredited realm. The Zion community represents the failure of a realized eschatology to recognize binding relationships of dependence and to steer a sustainable middle way between the mental and the physical.
Zur Kernacylierung von 1‐Methylphenothiazin. 7. Mitt.: Über Phenothiazinverbindungen (1965)

Abstract 1‐Methyl‐10‐acetylphenothiazin liefert in einer Friedel‐Crafts‐Reaktion 1‐Methyl‐2,10‐diacetylphenothiazin. Die Struktur dieser Verbindung wird aufgeklärt. 1‐Methyl‐2‐acetylphenothiazin wird nach Wolff‐Kishner zu 1‐Methyl‐2‐äthylphenothiazin reduziert, aus dem durch Desulfurierung mit Raney‐Nickel 2‐Methyl‐3‐äthyl‐diphenylamin gewonnen wird. Die Synthese von 2,3‐Dimethyldiphenylamin und 1,2‐Dimethylphenothiazin wird beschrieben.
The USE of CEA as an early indicator for gastrointestinal tumor recurrence and second-look procedures (1977)

Since 1972 plasma CEA levels of 25 cancer patients have been assayed to evaluate the reliability of CEA as an early indicator of recurrent gastrointestinal cancer. Identification of significant elevations in CEA levels required definition of exactly what a given value meant. Intraassay and interassay accuracy was determined and graphed as a CEA NOMOGRAM, which measures the observed CEA level against the 95% confidence limits for that observation and thus can be used to identify statistically significant increases. A statistically significant rise above a baseline value established by the NOMOGRAM proved to be a correct indicator of tumor recurrence in 22 (88%) of 25 patients who underwent second-look intraabdominal operations (22 colorectal, 2 gastric, and 1 pancreatic). In each case, other accepted procedures, such as liver enzymes, scans, and x-rays, were nondiagnostic. Of the 22 patients with proved tumor recurrence, 16 (73%) had distant metastases and 6 (27%) had localized tumors. One patient remains tumor-free three years after second-look operation and has had no significant change in CEA levels. More frequent serial CEA determinations combined with sound clinical judgment should facilitate earlier detection of recurrent gastrointestinal cancer.
A high-performance parameter-insensitive drive using a series-connected wound rotor induction motor (1989)

A parameter-insensitive drive system that utilizes the outer-loop sliding mode control and inner-loop decoupling control of a series-connected wound rotor induction machine (SCWRIM) is presented. The methods of decoupling control and torque linearization for the SCWRIM are outlined. Sliding mode control with cascaded integral operation is used to provide invariant speed response, improved steady-state accuracy, and reduced torque chattering. The scheme is implemented using a resolver-based system for speed and position sensing. The parameter-insensitive characteristics are demonstrated through computer simulations and experimental verifications.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>