gebhart/patrepeval huggingface dataset:
Improvement of Grauert-Riemenschneider's theorem for a normal surface (1982)

Let <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mover accent="true"> <mml:mi>X</mml:mi> <mml:mo>˜</mml:mo> </mml:mover> </mml:math> be a desingularization of a normal surface <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mi>X</mml:mi> </mml:math> . The group Pic <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:mo>(</mml:mo> <mml:mover accent="true"> <mml:mi>X</mml:mi> <mml:mo>˜</mml:mo> </mml:mover> <mml:mo>)</mml:mo> </mml:mrow> </mml:math> is provided with an order relation <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:mi>L</mml:mi> <mml:munder> <mml:mo>≫</mml:mo> <mml:mo>̲</mml:mo> </mml:munder> <mml:mn>0</mml:mn> </mml:mrow> </mml:math> , defined by <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mi>L</mml:mi> </mml:math> . <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:mi>V</mml:mi> <mml:mo>≤</mml:mo> <mml:mn>0</mml:mn> </mml:mrow> </mml:math> for any effective exceptional divisor <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mi>V</mml:mi> </mml:math> . Comparing to the usual order relation we define the ceiling of <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mi>L</mml:mi> </mml:math> which is an exceptional divisor. This notion allows us to improve the usual vanishing theorem and we deduce from it a numerical criterion for rationality and a genus formula for a curve on a normal surface; the difficulty lies in the case of a Weil divisor which is not a Cartier divisor.
Decreased epileptogenesis in mice lacking the System x<sub>c</sub><sup>−</sup> transporter occurs in association with a reduction in <scp>AMPA</scp> receptor subunit GluA1 (2019)

This study provides the first evidence that Sx<sub>c</sub> <sup>-</sup> signaling contributes to epileptogenesis in the PTZ kindling model of acquired epilepsy. Further data indicate that a reduction in AMPA receptor signaling could underlie the resistance to PTZ kindling uncovered in Sx<sub>c</sub> <sup>-</sup> null mice.
Loss of functional ELOVL4 depletes very long-chain fatty acids (≥C28) and the unique ω-O-acylceramides in skin leading to neonatal death (2007)

Mutations in elongation of very long-chain fatty acid-4 (ELOVL4) are associated with autosomal dominant Stargardt-like macular degeneration (STGD3), with a five base-pair (5 bp) deletion mutation resulting in the loss of 51 carboxy-terminal amino acids and truncation of the protein. In addition to the retina, Elovl4 is expressed in a limited number of mammalian tissues, including skin, with unknown function(s). We generated a knock-in mouse model with the 5-bp deletion in the Elovl4 gene. As anticipated, mice carrying this mutation in the heterozygous state (Elovl4(+/del)) exhibit progressive photoreceptor degeneration. Unexpectedly, homozygous mice (Elovl4(del/del)) display scaly, wrinkled skin, have severely compromised epidermal permeability barrier function, and die within a few hours after birth. Histopathological evaluation of the Elovl4(del/del) pups revealed no apparent abnormality(ies) in vital internal organs. However, skin histology showed an abnormally-compacted outer epidermis [stratum corneum (SC)], while electron microscopy revealed deficient epidermal lamellar body contents, and lack of normal SC lamellar membranes that are essential for permeability barrier function. Lipid analyses of epidermis from Elovl4(del/del) mice revealed a global decrease in very long-chain fatty acids (VLFAs) (i.e., carbon chain > or =C28) in both the ceramide/glucosylceramide and the free fatty-acid fractions. Strikingly, Elovl4(del/del) skin was devoid of the epidermal-unique omega-O-acylceramides, that are key hydrophobic components of the extracellular lamellar membranes in mammalian SC. These findings demonstrate that ELOVL4 is required for generating VLFA critical for epidermal barrier function, and that the lack of epidermal omega-O-acylceramides is incompatible with survival in a desiccating environment.
BUILDING SMALL (2011)

RETURN TO ISSUEPREVNewsNEXTBUILDING SMALLNanotechnology makes inroads in the CONSTRUCTION INDUSTRYBETHANY HALFORDView Author Information C&EN NORTHEAST NEWS BUREAUCite this: Chem. Eng. News 2011, 89, 24, 12–17Publication Date (Print):June 13, 2011Publication History Published online9 March 2012Published inissue 13 June 2011https://pubs.acs.org/doi/10.1021/cen-v089n024.p012https://doi.org/10.1021/cen-v089n024.p012newsACS PublicationsCopyright © 2011 AMERICAN CHEMICAL SOCIETYArticle Views16Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options SUBJECTS:Nanotechnology Get e-Alerts
Open Questions in Scientific Consensus Messaging Research (2020)

In recent years, there has been considerable interest in studying and using scientific consensus messaging strategies to influence public opinion. Researchers disagree, sometimes vociferously, about how to examine the potential influence of consensus messaging, debating one another publicly and privately. In this essay, we take a step back and focus on some of the important questions that scholars might consider when researching scientific consensus messaging. Hopefully, reflecting on these questions will help researchers better understand the reasons for the different points of debate and improve the work moving forward.
NANT cancer vaccine an orchestration of immunogenic cell death by overcoming immune suppression and activating NK and T cell therapy in patients with third line or greater metastatic pancreatic cancer. (2019)

TPS463 Background: Pancreatic cancer has multiple mechanisms to prevent immune recognition that lead to the creation of an immune suppressive tumor microenvironment. We hypothesize that effective and sustained response against tumors requires a coordinated approach that: 1. reverses the immune-suppressive tumor microenvironment, 2. induces immunogenic tumor cell death and 3. reengages NK and T-cell tumor response against a 4. cascade of tumor antigens. To test this hypothesis, we developed the NANT Cancer Vaccine (NCV), which combines metronomic low-dose chemotherapy, radiotherapy and multifaceted immunotherapy. In proof-of-concept trials, the NCV was tested in 10 patients with 3 rd -line or greater pancreatic cancer. These trials showed that the NCV could be safely administered in an outpatient setting, with AEs that were manageable by dose-reduction, and preliminary survival results that exceed the standard of care in this heavily-treated population. We believe these results warrant further research, and this abstract describes our newly-designed trial. Methods: A phase 1b, single-arm, open-label trial of the NANT Cancer Vaccine in patients with recurrent metastatic pancreatic cancer has been initiated. Treatment will occur in 3-week cycles of low-dose chemotherapy (aldoxorubicin, cyclophosphamide, oxaliplatin, nab-paclitaxel, 5-FU/L), antiangiogenic therapy (bevacizumab), SBRT, engineered allogeneic high affinity CD16 NK-92 cells (haNK), IL-15RαFc (N-803), adenoviral vector-based CEA vaccine (Ad-CEA), yeast vector-based RAS vaccine (Ye-RAS), and an IgG1 PD-L1 inhibitor, avelumab. The primary endpoint is incidence of treatment-related adverse events. Secondary endpoints include ORR, DCR, PFS, and OS. A maximum of 24 patients will be enrolled. Clinical trial information: NCT03586869.
Extraction and Recovery of Precious Metals from Plating Solutions Using Molecular Recognition Technology (2000)

SUMMARYConventional techniques for recovery of gold from dragout, plating, or stripping solutions, produce a gold product that must first be refined, and then converted back into potassium gold cyanide (PGC) for re-use. This procedure results in subsequent refining and conversion charges. With the molecular recognition technology (MRT) process, the gold can be directly extracted and converted to the form of potassium gold cyanide, resulting in substantial savings through elimination of the various costs and controls associated with gold refining. The recovered gold does not have to be remanufactured in the form of PGC, and can be quickly recycled. The PGC is deposited on the SuperLig® resin material, and can then be readily stripped into a concentrated aqueous solution for recycling. Results of tests on a commercial gold electroplating line are presented. Results of work conducted on recovery of palladium from a dipping bath of palladium/tin chloride catalyst solution are also reviewed.
Cytokine profile of myelin basic protein—reactive T cells in multiple sclerosis and healthy individuals (1997)

Myelin basic protein (MBP)-reactive T cells have been implicated in the autoimmune pathogenesis of multiple sclerosis (MS). In this study, we examined the cytokine profile of 531 primary MBP-reactive T-cell lines and 72 independently established clones from 32 patients with MS and 18 healthy controls (NS) by using highly sensitive enzyme-linked immunosorbent assays. An increased number of primary T-cell lines producing interferon-gamma (IFN gamma) and/or interleukin-4 (IL-4) in response to MBP were found in patients with MS compared with controls. No distinct Th1 or Th2 subtypes could be demonstrated among the MBP-reactive clones. IL-4 was more frequently observed among MS-derived clones. Clones derived from MS patients produced increased levels of IL-2, IL-4, tumor necrosis factor-alpha (TNF alpha), IFN gamma, and IL-10, but not IL-6. It is interesting that MBP-reactive T cells from MS patients expressing the disease-associated HLA-DRB1*15 allele produced increased quantities of TNF alpha, a cytokine suggested to play an important role in inflammation and demyelination. When challenged with either MBP or a bacterial superantigen, the clones expressed similar levels of the proinflammatory cytokine IFN gamma. Our study suggests a functional difference in T-cell responses to MBP in patients with MS compared with healthy individuals, and provides further insights into the role of MBP-reactive T cells and their cytokine profile in the inflammatory processes of MS.
Mastering algorithms with C (1999)

There are many books on data structures and algorithms, and some books laying out useful libraries of C functions, but this book aims to give you a unique combination of theoretical background and working code. In offering robust solutions for everyday programming tasks, Mastering Algorithms with C avoids the abstract style of most classic data structures and algorithms texts but still provides all the information you need to understand the purpose and use of common programming techniques. Implementations, as well as interesting, real-world examples of each data structure and algorithm, are shown in the text. Full source code appears on the accompanying disk. Using both a programming style and a writing style that are exceptionally clean, Kyle Loudon shows you how to use such essential data structures as lists, stacks, queues, sets, trees, heaps, priority queues, and graphs. He shows you how to use algorithms for sorting, searching, numerical analysis, data compression, data encryption, common graph problems, and computational geometry. He also describes the relative efficiency of all implementations. The compression and encryption chapters not only give you working code for reasonably efficient solutions, they explain concepts in an approachable manner for people who never have had the time or expertise to study them in depth. Anyone with a basic understanding of the C language can use this book. In order to provide maintainable and extendible code, an extra level of abstraction (such as pointers to functions) is used in examples where appropriate. Understanding that these techniques may be unfamiliar to some programmers, Loudon explains them clearly in the introductory chapters. Contents include: PointersRecursionAnalysis of algorithmsData structures (lists, stacks, queues, sets, hash tables, trees, heaps, priority queues, graphs)Sorting and searchingNumerical methodsData compressionData encryptionGraph algorithmsGeometric algorithms
Amidine- and amidinate-functionalised N-heterocyclic carbene complexes of silver and chromium (2012)

A new family of N,N′-bis-(2,6-diisopropylphenyl)-(2,6-diisopropylphenyl-imidazolium)-acetamidines have been developed as NHC proligands and ligands that are functionalised with neutral amidine and anionic amidinato moieties. On coordination they adopt diverse binding modes, depending on the nature of the metal and the reaction conditions. In the Ag, K and Cr complexes reported in this paper, monodentate κ1(NHC), bimetallic bridging-(κ1-NHC–κ1-amidinato) and bidentate (κ1-NHC–κ1-amidinato) binding modes were observed, respectively. Two of the novel Cr complexes, in the presence of activators, were tested as catalysts for the polymerisation of ethylene showing low activity.
Abbreviated Dynamic Source Routing: Source Routing with Non-Unique Network Identifiers (2005)

Current ad-hoc network protocols are designed for hosts similar to the ones that are used in fixed networks. These protocols are not suitable for some applications of ad-hoc networks, where resources are very scarce. One point is the size of the network addresses, which may be a critical issue, specially with the use of IPv6 in the DSR protocol. This is because this protocol uses source routing, and, therefore, each datagram must carry the addresses of all the machines in its path. In this paper a new protocol named ADSR is proposed to solve this problem. This new protocol is a modified version of DSR based on the use of abbreviated addresses. The abbreviation procedure can lead to two different nodes having the same address, which we will term collision. ADSR allows rather than averts collisions, as analysed in this paper. Some results on the performance of this new protocol are shown. These results have been obtained by simulations implemented on an ns-2 network simulator.
Onset and persistence of efficacy by symptom domain with long-acting injectable paliperidone palmitate in patients with schizophrenia (2014)

Symptom reductions from baseline with PP were significant by day 4 for all five PANSS factors in both studies. Some effects may have been driven by the presence or absence of a placebo response. A significant effect for PP versus placebo was observed for all major symptom domains for one or more doses of PP during the first month of treatment. Once established, most (but not all) significant responses persisted to the end point. Similar improvements were observed in PANSS scores with PP and oral risperidone. Dose-dependent trends were observed for the effect of PP on positive, negative and uncontrolled hostility/excitement symptoms.
Bacillus thermolactis sp. nov., isolated from dairy farms, and emended description of Bacillus thermoamylovorans (2010)

A polyphasic taxonomic study was performed on 22 thermotolerant, aerobic, endospore-forming bacteria from dairy environments. Seventeen isolates were retrieved from raw milk, one from a filter cloth and four from grass, straw or milking equipment. These latter four isolates (R-6546, R-7499, R-7764 and R-7440) were identified as Bacillus thermoamylovorans based on DNA-DNA hybridizations (values above 70 % with Bacillus thermoamylovorans LMG 18084(T)) but showed discrepancies in characteristics with the original species description, so an emended description of this species is given. According to 16S rRNA gene sequence analysis and DNA-DNA hybridization experiments, the remaining 18 isolates (R-6488(T), R-28193, R-6491, R-6492, R-7336, R-33367, R-6486, R-6770, R-31288, R-28160, R-26358, R-7632, R-26955, R-26950, R-33520, R-6484, R-26954 and R-7165) represented one single species, most closely related to Bacillus thermoamylovorans (93.9 % 16S rRNA gene sequence similarity), for which the name Bacillus thermolactis is proposed. Cells were Gram-stain-positive, facultatively anaerobic, endospore-forming rods that grew optimally at 40-50 °C. The cell wall peptidoglycan type of strain R-6488(T), the proposed type strain, was A1γ based on meso-diaminopimelic acid. Major fatty acids of the strains were C(16 : 0) (28.0 %), iso-C(16 : 0) (12.1 %) and iso-C(15 : 0) (12.0 %). MK-7 was the predominant menaquinone, and major polar lipids were diphosphatidylglycerol, phosphatidylglycerol and some unidentified phospholipids. DNA G+C content was 35.0 mol%. Phenotypic properties allowed discrimination from other thermotolerant species of the genus Bacillus and supported the description of the novel species Bacillus thermolactis, with strain R-6488(T) ( = LMG 25569(T) = DSM 23332(T)) as the proposed type strain.
Multilayer Fresnel Zone Plate with High-Diffraction Efficiency: Application of Composite Layer to X-Ray Optics (2011)

Composite materials are widely utilized in a number of fields, such as materials science, metallurgy, polymer science, interface science, mechanical engineering and aerospace engineering. In this chapter, as an application of a composite material layer (thin film) produced by co-sputtering to the hard X-ray focusing optical technique, a multilayer Fresnel zone plate (ML-FZP) with high diffraction efficiency is described. X-rays in the energy region of 100 -2,000 eV (2 keV) are called soft X-rays Soft X-rays, especially in the "water window" region On the other hand, hard X-rays are used in various research fields, including materials science, environmental science and medical science. High brilliant hard X-ray beams with submicron-or nanometre-scale spot sizes generated by third-generation synchrotron radiation (SR) facilities such as the APS (USA), ESRF (France) or SPring-8 (Japan), especially for use in the high-energy region, have great potential for use in various fields of research. They are remarkably powerful tools. Recently, higher energy (shorter wavelength) X-ray beams above 20 keV have been utilised in a number of applications, including residual stress measurement in metal matrix composites at 40 keV In addition, microscopic imaging of Au mesh at 200 keV has also been reported Many types of focusing optics have been developed for hard X-rays and their focusing abilities have been improved over the past two decades. Especially within the last several years, there have been dramatic changes in the performances of focusing optics. The main types of focusing optics and their performances are shown in Fig.
An Effective Technique for Symmetric Planar Monopole Antenna Miniaturization (2009)

The increase of mobile applications requires antennas ever smaller in form factor. In this paper, an effective method is presented for antenna size miniaturization of ultrawideband (UWB) monopole antennas with symmetric structure and perfect magnetic conductor (PMC) plane. Two small antennas are designed for pulsed UWB applications in the 3.1-10.6-GHz band with and without notch behavior in the band. The presented technique is applied to both antennas for an even further 50% area reduction. The performance of the miniaturized antennas is then compared with the main-size structures. Using both simulations and measurements the paper analyzes and demonstrates in detail the effectiveness of the presented technique in the time and frequency domain.
Effect of Home Blood Pressure Telemonitoring With Self-Care Support on Uncontrolled Systolic Hypertension in Diabetics (2012)

Lowering blood pressure reduces cardiovascular risk, yet hypertension is poorly controlled in diabetic patients. In a pilot study we demonstrated that a home blood pressure telemonitoring system, which provided self-care messages on the smartphone of hypertensive diabetic patients immediately after each reading, improved blood pressure control. Messages were based on care paths defined by running averages of transmitted readings. The present study tests the system's effectiveness in a randomized, controlled trial in diabetic patients with uncontrolled systolic hypertension. Of 244 subjects screened for eligibility, 110 (45%) were randomly allocated to the intervention (n=55) or control (n=55) group, and 105 (95.5%) completed the 1-year outcome visit. In the intention-to-treat analysis, mean daytime ambulatory systolic blood pressure, the primary end point, decreased significantly only in the intervention group by 9.1±15.6 mmHg (SD; P <0.0001), and the mean between-group difference was 7.1±2.3 mmHg (SE; P <0.005). Furthermore, 51% of intervention subjects achieved the guideline recommended target of <130/80 mmHg compared with 31% of control subjects ( P <0.05). These improvements were obtained without the use of more or different antihypertensive medications or additional clinic visits to physicians. Providing self-care support did not affect anxiety but worsened depression on the Hospital Anxiety and Depression Scale (baseline, 4.1±3.76; exit, 5.2±4.30; P =0.014). This study demonstrated that home blood pressure telemonitoring combined with automated self-care support reduced the blood pressure of diabetic patients with uncontrolled systolic hypertension and improved hypertension control. Home blood pressure monitoring alone had no effect on blood pressure. Promoting patient self-care may have negative psychological effects.
Selective Synthetic Ligands for Human Nuclear Retinoic Acid Receptors (1992)

From a series of naphthalene and benzoic acid derivatives we have identified synthetic retinoic acid analogues exhibiting high selectivity for the nuclear retinoic acid receptors RAR alpha (Am 580), RAR beta (CD 2019) and RAR gamma (CD 437) as well as ligands sharing high affinities for all RAR subtypes (CD 367). The compounds were evaluated in two complementary screening systems: (1) binding to nuclear proteins extracted from COS-7 cells after transfection with the appropriate expression vectors, and (2) induction of plasminogen activator in the embryonic mouse teratocarcinoma cell line F9. All compounds behaved as retinoic acid agonists in the F9 test.
Digital X-ray stereophotogrammetry for cochlear implantation (2000)

Multielectrode, intracochlear implant systems are effective treatment for profound sensorineural hearing loss. In some cases, these systems do not perform well, which may be partially due to variations in implant location within the cochlea. Determination of each electrode's position in a patient's inner ear provides an in vivo basis for both the cochlear modeling of electrical fields and the future design of electrode arrays that deliver electrical stimulation to surviving auditory neurons, and may improve speech processor programming for better speech recognition. We developed an X-ray stereophotogrammetric approach to localize implanted electrodes in three dimensions. Stereophotogrammetry of implanted electrodes is formulated in weak perspective geometry, with knowledge of a three-dimensional (3-D) reference structure and electrode positions in each of two digital stereo-images. The localization error is theoretically, numerically, and experimentally quantified. Both numerical and experimental results demonstrate the feasibility of the technique.
Die Synthese von 1,3‐disubstituierten Adamantanen (1976)

Synthesis of 1,3‐Disubstituted Adamantanes. A series of new 1‐substituted 3‐bromoadamantanes has been prepared. An improved method for the formation of cyclopropanes from olefins with diazomethane and copper salts is described.