gebhart/patrepeval huggingface dataset:
Surface-acoustic-wave components, devices and applications (1973)

Since the mid-1960s, there has been a strong upsurge of interest in the propagation of surface acoustic waves on solids. The stimulus for this interest came from the realisation that simple, compact, and potentially cheap surface-acoustic-wave devices could be made which performed valuable signal-processing functions principally at intermediate frequencies. In a very short space of time these devices have met demanding specifications and have been accepted for military systems.This article reviews the recent work on surface acoustic waves (s.a.w.s) with the main emphasis on devices and applications. The introductory section provides basic background information on the nature, propagation and transduction of s.a.w.s. In some s.a.w. devices, propagation of the surface wave is influenced by surface structures which reflect, couple, guide or amplify the wave, and these are reviewed prior to the main section which is devoted to the more important s.a.w. devices, i.e. delay lines, tapped delay lines, frequency filters, oscillators, fixed and programmable analogue matched filters, convolvers and correlators, and finally, devices related to displays.Surface-wave devices are beginning to have an impact in both radar and communications systems. Both these areas of application are reviewed with particular reference to code generation and matched filtering (pulse compression) for high-performance radars, correlation systems for simple radars, synthetic-clutter generation for clutter-reference radars, compressive receivers, processors for fusing and filters for acquisition of synchronisation in communication systems.At appropriate points in the review, basic limitations of s.a.w. devices are indicated and the competition offered by other devices is assessed.
Effects on Quality of Life of Combined Trastuzumab and Chemotherapy in Women With Metastatic Breast Cancer (2002)

Statistically significantly higher proportions of patients treated with a combination of trastuzumab and chemotherapy reported improved global QOL than did patients treated by chemotherapy alone.
Dilazep inhibits binding of batrachotoxin to sodium channels in canine sarcolemmal vesicles. (1997)

We studied the effect of dilazep on the binding of [3H]- batrachotoxinin A 20 alpha-benzoate ([3H]BTXB), which binds to and stabilizes the activated state of the Na+ channel, and compared it with that of lidocaine in canine cardiac sarcolemmal vesicles. Dilazep inhibited the specific [3H]BTXB binding in a dose-dependent manner with an IC50 value of 0.37 microM, while lidocaine inhibited it with an IC50 value of 92 microM. Scatchard analysis of [3H]BTXB binding demonstrated that both dilazep and lidocaine reduced the amax without a marked effect on the K(D). The inhibition of [3H]BTXB induced by dilazep was reversible. Both dilazep (4 microM) and lidocaine (100 microM) increased the dissociation rate constant of [3H]BTXB only in concentrations which are about a 10-fold greater than their IC50, indicating the low affinity of both drugs for the [3H]BTXB-bound Na+ channel. However, dilazep (0.5 microM) and lidocaine (100 microM) decreased significantly the association rate constant of the [3H]BTXB binding at concentrations near their IC50, indicating that the affinity of both drugs for the [3H]BTXB-unbound Na+ channel is relatively high. These results suggest that, in canine cardiac membrane vesicles, the effect of dilazep in inhibiting the binding of [3H]BTXB and stabilizing the Na+ channel is similar to that of lidocaine, but the potency of dilazep is greater than that of lidocaine.
Activation of creatine kinase activity in lyophilized control materials (1977)

The activity of creatine kinase in lyophilized control materials has been studied. In most such samples the activity was highly dependent upon time of exposure to the reagent system including the thiol activator, increasing pre-incubation time gave rise to increasing activities of creatine kinase. The increase of the activity could be prevented by reconstitution in presence of a thiol activator. In this way stable control materials was obtained for use in several days.
Vertical constrained coding for phase-change memory with thermal crosstalk (2014)

Phase-change memory (PCM) has been widely considered as one of the most promising non-volatile memory (NVM) technologies due to its high scalability and cost effectiveness. A critical reliability issue caused by PCM cell down scaling is the thermal crosstalk, which leads to the change of a cell's state while its adjacent cells are being programmed by a high-current reset pulse. In this paper, we propose novel vertical constrained coding scheme in conjunction with parallel programming to mitigate the thermal crosstalk for PCM in both the bit-line (BL) and word-line (WL) directions. We further propose efficient finite-state encoding methods to design capacity-approaching constrained codes which serve as base codes of the vertical constrained coding scheme. Simulation results show that the proposed schemes can effectively reduce the probability of disturbed bits due to thermal crosstalk, and hence help to push the scaling limitation of PCM. It has also been found that the proposed constrained coding scheme can reduce the probability of the reset state, and thereby improve the endurance of PCM.
Content-Based 3D Mosaic Representation for Video of Dynamic 3D Scenes (2006)

We propose a content-based 3D mosaic representation for long video sequences of 3D and dynamic scenes captured by a camera on a mobile platform. The motion of the camera has a dominant direction of motion (as on an airplane or ground vehicle), but 6 degrees-of-freedom (DOF) motion is allowed. In the first step, a pair of generalized parallel-perspective (pushbroom) stereo mosaics is generated that captured both the 3D and dynamic aspects of the scene under the camera coverage. In the second step, a segmentation-based stereo matching algorithm is applied to extract parametric representation of the color, structure and motion of the dynamic and/or 3D objects in urban scenes where a lot of planar surfaces exist. Based on these results, the content-based 3D mosaic (CB3M) representation is created, which is a highly compressed visual representation for very long video sequences of dynamic 3D scenes. Experimental results are given.
An Underwater Surface‐Drying Peptide Inspired by a Mussel Adhesive Protein (2016)

Water hampers the formation of strong and durable bonds between adhesive polymers and solid surfaces, in turn hindering the development of adhesives for biomedical and marine applications. Inspired by mussel adhesion, a mussel foot protein homologue (mfp3S-pep) is designed, whose primary sequence is designed to mimic the pI, polyampholyte, and hydrophobic characteristics of the native protein. Noticeably, native protein and synthetic peptide exhibit similar abilities to self-coacervate at given pH and ionic strength. 3,4-dihydroxy-l-phenylalanine (Dopa) proves necessary for irreversible peptide adsorption to both TiO<sub>2</sub> (anatase) and hydroxyapatite (HAP) surfaces, as confirmed by quartz crystal microbalance measurements, with the coacervate showing superior adsorption. The adsorption of Dopa-containing peptides is investigated by attenuated total reflection infrared spectroscopy, revealing initially bidentate coordinative bonds on TiO<sub>2</sub>, followed by H-bonded and eventually long-ranged electrostatic and Van der Waals interactions. On HAP, mfp3s-pep-3Dopa adsorption occurs predominantly via H-bond and outer-sphere complexes of the catechol groups. Importantly, only the Dopa-bearing compounds are able to remove interfacial water from the target surfaces, with the coacervate achieving the highest water displacement arising from its superior wetting properties. These findings provide an impetus for developing coacervated Dopa-functionalized peptides/polymers adhesive formulations for a variety of applications on wet polar surfaces.
ZnCl<sub>2</sub>‐Promoted Asymmetric Hydrogenation of β‐Secondary‐Amino Ketones Catalyzed by a P‐Chiral Rh–Bisphosphine Complex (2014)

A new catalytic system has been developed for the asymmetric hydrogenation of β-secondary-amino ketones using a highly efficient P-chiral bisphosphine-rhodium complex in combination with ZnCl2 as the activator of the catalyst. The chiral γ-secondary-amino alcohols were obtained in 90-94 % yields, 90-99 % enantioselectivities, and with high turnover numbers (up to 2000 S/C; S/C=substrate/catalyst ratio). A mechanism for the promoting effect of ZnCl2 on the catalytic system has been proposed on the basis of NMR spectroscopy and HRMS studies. This method was successfully applied to the asymmetric syntheses of three important drugs, (S)-duloxetine, (R)-fluoxetine, and (R)-atomoxetine, in high yields and with excellent enantioselectivities.
Peri‐operative anaphylaxis (2011)

Peri-operative anaphylaxis is an important cause for mortality and morbidity associated with anaesthesia. The true incidence is unknown and is most likely under reported. Diagnosis can be difficult, particularly as a number of drugs are given simultaneously and any of these agents can potentially cause anaphylaxis. This review covers the clinical features, differential diagnosis and management of anaphylaxis associated with anaesthesia. The investigations to confirm the clinical suspicion of anaphylaxis and further tests to identify the likely drug(s) are examined. Finally the salient features of common and rare causes including non-drug substances are described.
Synthesis of Methyl 1-O-(4-Hydroxymethamphetaminyl)-.ALPHA.-D-glucopyranouronate (2005)

For the purpose of the direct characterization of the intact conjugated form in the urine of a methamphetamine (MA) abuser, 4-hydroxymethamphetamine (4-OHMA) glucuronate, corresponding to one of the metabolites of MA, was synthesized from the commercially available methyl 4-hydroxyphenylacetate.
Insertion of a Coiled-Coil Peptide from Influenza Virus Hemagglutinin into Membranes (1994)

The trimeric protein hemagglutinin (HA) of the influenza viral envelope is essential for cell entry. To investigate the interaction of HA with membranes, two 40-residue, cysteine-substituted peptides comprising the loop region and the first part of the coiled-coil stem were synthesized and modified with a nitroxide spin label. Electron paramagnetic resonance analysis revealed that the peptide inserts reversibly into phospholipid vesicles under endosomal pH conditions. This result suggests that some or all of the long coiled-coil trimer of HA may insert into membranes, which could bring the viral and cell membranes closer together and facilitate fusion.
The Functional Effect of Mild Outlet Obstruction on the Rabbit Urinary Bladder (1988)

Bladder outlet obstruction has been the subject of numerous studies. In previous studies on severe obstruction, the initial response of the bladder has been to produce an acute overdistension of the bladder resulting in severe tissue damage and functional disorders. This is quite different from the slow onset of outlet obstruction seen in association with benign prostatic hypertrophy (BPH). The present study describes the functional effect of mild outlet obstruction created in a rabbit model, and compares it to a previously described model of severe obstruction. Mild bladder outlet obstruction was created by placing a silicon sleeve (inner circumference 30 mm.) around the bladder neck of mature male NZW rabbits. Individual groups of rabbits were studied at one, seven, and 14 days following the creation of the outlet obstruction. The following studies were performed on each group of rabbits: in vivo and in vitro cystometry, field stimulation and cholinergic stimulation using the in vitro whole bladder model. In addition, the tissue concentration of ATP (adenosine triphosphate) and CP (creatine phosphate) and the muscarinic receptor density were determined. The obstructed bladders showed no significant cystometric difference at one day, but revealed a marked decrease of compliance and capacity at one and two weeks. Unlike the response to severe outlet obstruction, there was no initial acute overdistension of the bladder wall. Although the ability of the obstructed bladders to generate intravesical pressure in response to both field stimulation and bethanechol did not decrease, the ability of both forms of stimulation to empty the obstructed bladders was markedly impaired. The response to field stimulation was reduced to a significantly greater extent than the response to bethanechol, indicating neuronal damage. The muscarinic receptor number per bladder was increased above control at all time periods. The intracellular concentration of ATP and CP in the obstructed bladders was similar to that of control. Our present model of mild obstruction was not accompanied by a massive increase in tissue mass nor was there an overdistension of the detrusor; thus, this model would be a more suitable model for the study of clinical outlet obstruction.
The ω‐hydroxylation of arachidonic acid by human polymorphonuclear leukocytes (1988)

Incubations of [1-14C]arachidonic acid with unstimulated human polymorphonuclear leukocytes resulted in the formation of four new metabolites in a previously described reverse-phase HPLC system. Three of these metabolites were largely suppressed in a CO/O2 (80/20, by vol.) atmosphere indicating a cytochrome-P450-dependent monooxygenase reaction. In agreement with this assumption is their NADPH/O2-dependent formation in the microsomal fraction. One metabolite was identified by gas chromatography/mass spectrometry analysis as omega-hydroxy-arachidonic acid and the two others were secondary products identified as omega-carboxy-arachidonic acid and 5,20-dihydroxy-E,Z,Z,Z-6,8,11,14-eicosatetraenoic acid. Since the affinity for arachidonate of the omega-monooxygenase was quite low and the presence of LTB4 suppressed the omega-hydroxylation of arachidonate, we conclude that the known LTB4 omega-monooxygenase is responsible for the formation of omega-hydroxy-arachidonate. It is unlikely, however, that significant concentrations of these metabolites are formed by activated polymorphonuclear leukocytes in vivo. The fourth metabolite remains tightly associated with the leukocytes but has not been further characterized.
Influence of oryzanol on platelet aggregation in rats. (1990)

Platelet aggregation was measured using platelet rich plasma prepared from rats fed oryzanol in the control diet and those fed oryzanol in a 1 per cent cholesterol diet (HCD). Oryzanol with the control diet did not alter platelet aggregation induced by ADP and collagen. On the other hand, oryzanol fed along with HCD significantly inhibited platelet aggregation induced by ADP and totally inhibited aggregation induced by collagen.
Performance Analysis of Different Length Packets Processing by Network Processor Based Application (2006)

In this work, we present a new methodology to calculate the available compute budget which determines how much processing the network processor can perform on each packet with different length. To evaluate the method, we also did a wide range of tests with different length packets. Then we analysis the MicroEngine states with the test results, which is useful in building the applications on network processors and evaluating its performance. We also give several solutions to solving the applications' performance bounds such as latency bound and compute bound, which are caused by variable length packets
Estimating the call option values embedded in closed‐end automobile leases (1996)

Believes that a feature of most closed‐end automobile leases is the right to purchase the car for a specified price at the termination of the lease. This characteristic of a closed‐end autombile lease is similar to a European call option and is transferred to the lessee at no explicit charge. Develops a methodology to calculate the value of the call option feature embedded in closed‐end automobile leases. Concludes that the rational lessee should lease autos that generate low option values.
Dual-factor loaded functional silk fibroin scaffolds for peripheral nerve regeneration with the aid of neovascularization (2016)

Dual-factor loaded functional silk fibroin scaffolds enhanced peripheral nerve regeneration with the aid of neovascularization.
Preparing for the New Economy: Advertising Strategies and Change in Destination Marketing Organizations (2000)

Information technology, especially the World Wide Web, has had a tremendous impact on the tourism industry over the past years. It is difficult for most destination marketing organizations, however, to keep pace with the evolution of new technologies, the emergence of innovative advertising strategies, the changes in the consumer market, and the growing competition due to increasing globalization. The National Laboratory for Tourism and eCommerce organized a workshop in an effort to identify effective strategies for tourism advertising on the Internet. The results indicated that information technology has led to a number of profound changes in the assumptions underlying communication strategies. It was concluded that the change occurring in the new economy involves a rethinking of who partners and competitors are and how networks with other organizations can increase organizational capacity to learn. Thus, it is argued that success of destination marketing organizations in the new economy is more about change in approach than technology itself.
Emerging role of thiamine therapy for prevention and treatment of early‐stage diabetic nephropathy (2011)

Thiamine supplementation may prevent and reverse early-stage diabetic nephropathy. This probably occurs by correcting diabetes-linked increased clearance of thiamine, maintaining activity and expression of thiamine pyrophosphate-dependent enzymes that help counter the adverse effects of high glucose concentrations-particularly transketolase. Evidence from experimental and clinical studies suggests that metabolism and clearance of thiamine is disturbed in diabetes leading to tissue-specific thiamine deficiency in the kidney and other sites of development of vascular complications. Thiamine supplementation prevented the development of early-stage nephropathy in diabetic rats and reversed increased urinary albumin excretion in patients with type 2 diabetes and microalbuminuria in two recent clinical trials. The thiamine monophosphate prodrug, Benfotiamine, whilst preventing early-stage development of diabetic nephropathy experimentally, has failed to produce similar clinical effect. The probable explanations for this are discussed. Further definitive trials for prevention of progression of early-stage diabetic nephropathy by thiamine are now required.
A new toroidal multi-dimensional network (2002)

We present a new multi-dimensional network architecture arranged in alternated regular mesh fashion (D-ARM) with toroidal boundaries. Each node of the D-ARM network has D incoming links and D outgoing links. The node address inside the network is represented by a D-dimensional vector, I=(i/sub D/, ..., i/sub 2/, i/sub 1/), whose entries assume no-negative integer values. Each of the D outgoing links in a given node is parallel to one coordinate axis of the D-dimensional orthogonal coordinate system. Therefore, each node has exactly one incoming link and one outgoing link in each dimension. The direction of an outgoing link can be crescent or decrescent with respect to the orientation of the coordinate axis. We establish the direction of a d/sup t/h dimensional outgoing link of a given node. Due to the global isotropy of the D-ARM network, a shortest path routing algorithm can be easily implemented. To evaluate the network performance, we calculate the mean transfer delay when the network running the shortest path routing algorithm.
Self-folding mobile microrobots for biomedical applications (2014)

The presented microrobotic platform combines the advantages of self-folding NIR light sensitive polymer bilayers, magnetic alginate microbeads, and a 3D manipulation system and introduces a solution for targeted, on-demand drug and cell delivery. First feasibility studies are presented together with the potential of the full design.
Conversion of Benzylamine to N-Substituted Thiobenzamides (1948)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConversion of Benzylamine to N-Substituted ThiobenzamidesFreeman H. McMillanCite this: J. Am. Chem. Soc. 1948, 70, 2, 868–869Publication Date (Print):February 1, 1948Publication History Published online1 May 2002Published inissue 1 February 1948https://pubs.acs.org/doi/10.1021/ja01182a512https://doi.org/10.1021/ja01182a512research-articleACS PublicationsRequest reuse permissionsArticle Views257Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Fibronectin in artery subendothelium is important for platelet adhesion (1985)

The role of subendothelial fibronectin in platelet interaction with subendothelium was studied. Human umbilical artery subendothelium was exposed to flowing blood containing 111In-labeled platelets in an annular perfusion chamber. Platelet adhesion was determined from the 111In radioactivity on the vessel wall. When perfusions were performed for five minutes at a wall shear rate of 1,800 s-1, platelet adhesion was the same whether normal plasma or fibronectin-free plasma was used. Preincubation of subendothelium with rabbit anti-human fibronectin serum, however, resulted in a marked inhibition of platelet adhesion. Preincubation with normal rabbit serum had no effect. Platelet adhesion was also diminished when the vessel wall was preincubated with anti- fibronectin IgG fraction or F(ab')2 fragment. After the latter preincubations, frozen sections of 4 micron were incubated with fluorescein isothiocyanate-conjugated goat anti-rabbit IgG, F(ab')2 fragment specific. Fluorescence was seen throughout the subendothelium both before and after perfusion. No fluorescence was seen when subendothelium was preincubated with normal rabbit IgG or F(ab')2 or with anti-fibronectin IgG that had been absorbed with purified fibronectin. After absorption of anti-fibronectin IgG with purified fibronectin, the inhibiting effect on platelet adhesion was also no longer present. Preincubation of the vessel wall with anti-fibronectin IgG reduced platelet adhesion significantly at a wall shear rate of 800 s-1. This effect was even greater at 1,800 s-1. At low shear rate (400 s-1), there was no inhibition.
Nanoscale Particle Therapies for Wounds and Ulcers (2010)

'Small is beautiful' - this should be the slogan of nanoscientists. Indeed, working with particles less than 100 nm in size, nanotechnology is on the verge of providing a host of new materials and approaches, revolutionizing applied medicine. The obvious potential of nanotechnology has attracted considerable investment from governments and industry hoping to drive its economic development. Several areas of medical care already benefit from the advantages that nanotechnology provides and its application in wound healing will be reviewed in this article.