gebhart/patrepeval huggingface dataset:
Load reduction using pressure difference on airfoil for control of trailing edge flaps (2009)

This work investigates the fatigue load reduction potential of using unsteady measurements of pressure differences over the pressure and suction sides of an airfoil to control a Trailing Edge (TE) flap.Analysis using unsteady thin airfoil potential flow theory shows that a fairly good estimation of the unsteady lift of an airfoil equipped with a TE flap is possible using a measurement of the pressure difference at only one single chordwise position.Theory furthermore predicts a very accurate prediction of unsteady lift using measurement of the unsteady pressure differences at two different chordwise positions.These insights were used to develop two simple TE control algorithms based on pressure measurements on an airfoil.Simulations in a 2D aeroelastic simulation tool showed that the control algorithm based on one pressure difference measurement resulted in a good load reduction potential whereas the TE control based on the finer estimation of the unsteady loads turned out to be aeroelastically unstable due to coupling with the structural torsional degree of freedom.
Role of lipase in the regulation of postprandial gastric acid secretion and emptying of fat in humans: a study with orlistat, a highly specific lipase inhibitor (2000)

Lipase has an important role in the regulation of postprandial gastric acid secretion and fat emptying in humans. These effects might be explained by lipolysis induced release of cholecystokinin.
Factor VIII Procoagulant Antigen in Human Tissues (1988)

The localization of factor VIII procoagulant antigen (VIII:Ag) and factor VIII von Willebrand antigen (VWF:Ag) was investigated in human liver, lung, spleen, placenta and umbilical cord, by an immunoperoxidase technique using an avidin biotin complex (ABC). Positive staining for VIII:Ag was observed in the endothelial cells of liver sinusoids, veins and arteries, as well as in the endothelial cells of placenta, lung and spleen. VWF:Ag was detected in the vascular endothelial cells of all the organs explored. The staining intensity of both VIII:Ag and VWF:Ag varied in the different tissues and showed a distinctive pattern of distribution in the liver. VIII:Ag was also observed in the cytoplasm of dysplastic, foetal-like hepatocytes which infiltrated one liver specimen. Our results agree with the view that liver endothelial cells are a major site of Factor VIII (F VIII) storage and secondary release into the circulation. However, the bright staining intensity of VIII:Ag and VWF:Ag in the lung and placenta suggests that these two tissues might also be a substantial source of F VIII.
Recombination in the Plant Genome and its Application in Biotechnology (1999)

Genetic variation within and between species is based on recombination of DNA molecules. Recombination also plays a very important role in the repair of damaged DNA. Clarity about the mechanism by which recombination occurs is of profound interest not only to understand how this process assures the maintenance of genome integrity and at the same time is the driving force of evolution, but also for its application in biotechnology. The isolation of genes involved in recombination and the elucidation of the role of many of the corresponding gene products in Escherichia coli and Saccharomyces cerevisiae has formed the basis for comparative analysis in other, more complex eukaryotic systems. The identification of homologous genes from different organisms, including plants, suggests a conservation of the general mechanisms of recombination. Transgenes introduced in an organism may be incorporated in the genome by either homologous or nonhomologous recombination (end joining). The preferred pathway differs strongly between organisms. In plants there is a preference for random integration of the introduced DNA by nonhomologous recombination, which might lead to the accidental inactivation of important genes and to variable and unpredictable expression of the transgene itself. Therefore, there is an urgent need for the development and improvement of techniques for the directed integration of transgenes at specific locations in the genome. The integration of transgenes by homologous recombination would allow specific modification or disruption of endogenous genes, providing a tool for more detailed analysis of gene function. In combination with the recent introduction of site-specific recombination systems from E. coli or yeast into plants, this may lead to the development of versatile systems for modification of the plant genome.
Tripodal Ionophore with Sulfate Recognition Properties for Anion-Selective Electrodes (2000)

Ionophore topology has a profound effect on the behavior of ion-selective electrodes. This is demonstrated with a new class of ionophores that incorporates aminochromenone moieties linked through urea spacers to different scaffolds that preorganize the ionophore binding cleft into tripodal topologies. Tris(2-aminoethylamine) and cis-1,3,5-tris(aminomethyl)cyclohexane were employed as the scaffolds. The two differ in their rigidity and in the size of ionophore cavity that they create. The electrodes based on the ionophore that incorporates the tris(2-aminoethylamine) scaffold show anti-Hofmeister behavior with an improved selectivity for sulfate. In contrast, the ionophore with the cis-1,3,5-tris(aminomethyl)cyclohexane scaffold exhibits a more Hofmeister-like response.
Administration of fusion cytokines induces tumor regression and systemic antitumor immunity (2021)

It is difficult to improve the curative effects of cancer immunotherapy on solid tumors. Cytokines, as powerful immune regulators, show potential in activating host antitumor immunity. We have previously found that the administration of certain cytokine combinations induces complete tumor clearance. Here, we constructed cognate fusion cytokines and evaluated their antitumor effects in various mouse tumor models. The in situ induction of the expression of the fusion cytokine IL12IL2GMCSF caused tumor eradication, including that of the tumors at advanced stages. An immune memory against unrelated syngeneic tumors was also elicited. Furthermore, flow cytometry analysis revealed that tumor-infiltrating CD3+ cells were greatly increased in the treated tumors and were accompanied by an elevation of CD8+/CD4+ ratios. This fusion protein exhibited superior immune activating capability compared to that of cytokine mixtures, in the experiments done in vitro. We also induced tumor regression in various immunocompetent tumor models via intratumoral injection. To improve its translational potential for clinical application, a systemically-administered immunocytokine, IL12IL2DiaNFGMCSF, was constructed by inserting a tumor-targeting diabody in the fusion protein. This protein also displayed good immune stimulating activities in vitro. Intravenous infusion of IL12IL2DiaNFGMCSF induced tumor-infiltrating immune cell alterations like IL12IL2GMCSF, with moderate serum IFNγ increment. Therapeutic effects were observed in the various tumor models after systemic administration of IL12IL2DiaNFGMCSF, but with slight toxicity. These results show the feasibility of developing a versatile cancer immunotherapy.
TOMORROW'S MOTIVE POWER (1995)

In recent years, the Association of American Railroads' (AAR) Research and Test (R&T) Department has changed its motive power research focus from examining ways to improve the efficiency and reliability of the in-use fleet to looking at long range, high risk technologies for the next century. Three promising long range technologies that AAR's R&T is pursuing are oxygen enrichment of the inlet air for diesel engines, flywheel energy storage, and fuel cells. These disparate technologies all affect prime mover capital cost, utilization, maintenance requirements, and fuel economy.
Sampled Dense Matrix Multiplication for High-Performance Machine Learning (2018)

Many machine learning methods involve iterative optimization and are amenable to a variety of alternate formulations. Many currently popular formulations for some machine learning methods based on core operations that essentially correspond to sparse matrix-vector products. A reformulation using sparse matrix-matrix products primitives can potentially enable significant performance enhancement. Sampled Dense-Dense Matrix Multiplication (SDDMM) is a primitive that has been shown to be usable as a core component in reformulations of many machine learning factor analysis algorithms such as Alternating Least Squares (ALS), Latent Dirichlet Allocation (LDA), Sparse Factor Analysis (SFA), and Gamma Poisson (GaP). It requires the computation of the product of two input dense matrices but only at locations of the result matrix corresponding to nonzero entries in a sparse third input matrix. In this paper, we address the development of cuSDDMM, a multi-node GPU-accelerated implementation for SDDMM. We analyze the data reuse characteristics of SDDMM and develop a model-driven strategy for choice of tiling permutation and tile-size choice. cuSDDMM improves significantly (up to 4.6x) over the best currently available GPU implementation of SDDMM (in the BIDMach Machine Learning library).
Risk Factors Influencing Survival in Acute Renal Failure Treated by Hemodialysis (1985)

A retrospective analysis of 58 patients with acute renal failure treated by hemodialysis between 1980 and 1984 was carried out to study mortality and the risk factors that might adversely influence survival. Twenty-six factors, suggested by published data to be relevant to the short-term prognosis of such patients, were evaluated by univariate analysis. Survivors were found to be significantly younger, they were less frequently malnourished or jaundiced, and fewer required inotropic drugs (due to hypotension) or ventilator support after the first week of their illness. Sepsis, heart failure, central nervous system depression, and a greater number of the above complications were characteristic in the nonsurvivors. Multivariate analysis suggests that the probability of survival could be estimated by taking into account three of these factors: age, central nervous system depression, and hypotension. Further studies would be appropriate to test the predictive value of such a probability equation.
Applications of In-Source Fragmentation of Protein Ions for Direct Sequence Analysis by Delayed Extraction MALDI-TOF Mass Spectrometry (1998)

In matrix-assisted laser desorption/ionization of proteins, there exists a certain amount of fast metastable decay immediately after laser irradiation. The fragment ions thus formed can be resolved and their m/z values measured accurately by employing delayed extraction linear time-of-flight mass spectrometry. At higher than threshold laser fluences, proteins exhibit a series of fragment ions providing useful sequence information. We also observe that when moderate amounts of salts are present in the sample with sinapinic acid being the matrix, the intensities of cn ions (N-terminal fragments) are enhanced compared to other types of fragment ions. This enhancement in cn ion signals allows direct sequencing of proteins. The cn ions are completely absent when Xxx-Pro bonds are encountered and are of lower intensity when Xxx-Gly bonds are involved. Further, the cn ion series is interrupted at Xxx-Cys, when the cysteine is involved in a disulfide bond. Upon reduction of the disulfide bonds, the series continues and information is available for longer stretches. Using 10-20 pmol of recombinant proteins, sometimes contiguous sequence information up to 70 residues is obtained in a matter of minutes. Applications of the technique to some recombinant proteins with intra- or interchain disulfide linkages are presented.
Identification of cis-acting regulatory elements controlling interleukin-4 gene expression in T cells: roles for NF-Y and NF-ATc. (1993)

Activity of the murine interleukin-4 (IL-4) promoter was localized to several cis-acting elements present within the first 300 bp from the transcriptional initiation site. Five repeated elements, P0 to P4, that share the common consensus ATTTTCCNNT were located between -40 and -250, and each was shown to interact with the T-cell-specific factor NF(P). These distinct P sites appear functionally interchangeable and cooperatively confer cyclosporin A-sensitive and ionomycin-inducible promoter activity. NF(P) may be closely related to the cytoplasmic component of NF-AT (nuclear factor of activated T cells), a T-cell-specific factor essential for IL-2 gene transcription, as judged from indistinguishable molecular weights and protease fragmentation patterns of UV-photolabeled factors. Also, we identified an element in the IL-4 promoter with homology to the Y box common to all major histocompatibility complex class II gene promoters. Our data show that the IL-4 promoter Y box -114CTGATTGG-107 significantly enhances overall promoter activity, since point mutations within this element diminish promoter activity by 85%. The factor binding this region is indistinguishable from the cloned nuclear factor NF-Y, as judged from interactions with specific anti-NF-Y monoclonal and polyclonal antibodies. Last, we point out the presence of two sites that share sequence identity to the OAP region of the ARRE-1 site within the IL-2 promoter (K. S. Ullman, W. M. Flanagan, C. A. Edwards, and G. R. Crabtree, Science 254:558-562, 1991). These regions, -85GTGTAATA-78 and -245GTGTAATT-238, reside adjacent to the NF(P) binding sites P1 and P4 and bind a distinct nuclear factor.
Up-conversion of red light to green by a new type of light transducer using organic electroluminescent diode combined with photoresponsive amorphous silicon carbide (1991)

Light up-conversion from red to green was performed in a new type of light transducer composed of an organic electroluminescent diode and a photoresponsive amorphous silicon carbide (a-SiC:H) film as an electron photoinjecting electrode. Quantum efficiency of photon conversion reached 1% with the assistance of newly observed photocurrent multiplication in a-SiC:H film.
Formation mechanism of ZnS impurities and their effect on photoelectrochemical properties on a Cu2ZnSnS4 photocathode (2014)

Cu2ZnSnS4 (CZTS) nanocrystals were synthesized by a hot injection method. Ultraviolet (UV) Raman spectroscopy measurements showed that ZnS impurities existed in CZTS with a Zn/Sn precursor ratio of 1.2. Combining Raman spectra with energy-dispersive X-ray spectroscopy (EDS) characterization, the formation mechanism of CZTS and ZnS impurities were also investigated. We found that crystalline CZTS and Cu2SnS3, as well as amorphous ZnS, formed after sulfur–oleylamine was injected into the mixture solution. Amorphous ZnS reacted with Cu2SnS3 to form CZTS during sulfur annealing at high temperature. However, if the Zn/Sn ratio was too high, the excess ZnS could not be eliminated even after a longer reaction time. A relatively pure phase of CZTS was only obtained by decreasing the Zn/Sn precursor ratio to 0.6. Moreover, CZTS nanocrystals were assembled into thin films by electrophoretic deposition onto molybdenum-coated soda lime glass and the photoelectrochemical properties of CZTS photocathodes with and without ZnS impurities were investigated. A CZTS photocathode without ZnS demonstrated higher photocurrent than those with ZnS. The results will deepen the understanding of the CZTS formation process and be helpful to explore efficient CZTS solar conversion devices.
Light-Driven Open−Close Motion of Chiral Molecular Scissors (2003)

The first example of "light-driven chiral molecular scissors" (1), which consists of 1,1',3,3'-tetraarylferrocene as a pivot part and azobenzene as a driving part, was synthesized. Absorption, circular dichroism (CD), and 1H NMR spectral studies on the photoinduced isomerization process of an enantiomer of 1 agreed well with a prediction by a DFT calculation, where a motion of the handles via light-driven contraction/expansion of the connecting azobenzene strap was transformed, through a pivotal motion of the ferrocene unit, into an open-close motion of the blade parts.
Polymer‐derived SiCN cellular structures from replica of 3D printed lattices (2018)

Abstract In comparison with metals and polymers, ceramics and/or carbon are more difficult to process into well‐defined cellular architectures (e.g., cubic, tetrakaidecadehron, etc.) using Additive Manufacturing techniques. The present work reports a simple method for generating complex and precise SiCN ceramic lattices using a preceramic polymer and applying the replica approach to structures fabricated using stereolithography of plastic materials, with the associated ease of fabrication. Three‐dimensional printed plastic lattices impregnated with a polysilazane were converted to SiCN by pyrolysis at 1000°C in inert atmosphere. In spite of the high amount of mass loss (~58%) and volume shrinkage (~65%), the impregnated structures did not collapse during pyrolysis, leading to highly porous (total porosity ~93 vol%) components possessing suitable strength for handling and potential use as lightweight components.
Rat Brain Contains High Levels of Mannose-6-phosphorylated Glycoproteins Including Lysosomal Enzymes and Palmitoyl-Protein Thioesterase, an Enzyme Implicated in Infantile Neuronal Lipofuscinosis (1996)

Mannose 6-phosphate (Man-6-P) is a posttranslational carbohydrate modification typical of newly synthesized acid hydrolases that signals targeting from the Golgi apparatus to the lysosome via Man-6-P receptors (MPRs). Using iodinated cation independent MPR as a probe in a Western blot assay, we surveyed levels of Man-6-P glycoproteins in a number of different rat tissues. Considerable variation was observed with respect to total amounts and types of Man-6-P glycoproteins in the different tissues. Brain contained 2-8-fold more Man-6-P glycoproteins than other tissues, with relative abundance being brain >> testis approximately heart > lung approximately kidney approximately ovary approximately spleen > skeletal muscle approximately liver approximately serum. Analysis of 16 different lysosomal enzyme activities revealed that brain contains lower activities than other tissues which suggested that decreased removal of Man-6-P results in increased levels of Man-6-P glycoproteins. This was directly demonstrated by comparing activities of phosphorylated lysosomal enzymes, purified by immobilized MPR affinity chromatography, with total activities. The phosphorylated forms accounted for a considerable proportion of the MPR-targeted activities measured in brain (on average, 36.2%) but very little in lung, kidney, and liver (on average, 5.5, 2.3, and 0. 7%, respectively). Man-6-P glycoproteins were also isolated from rat brain by MPR affinity chromatography on a preparative scale. Of the 18 bands resolvable by SDS-polyacrylamide gel electrophoresis, seven bands were NH2-terminally sequenced and identified as the known lysosomal enzymes cathepsin L, cathepsin A, cathepsin D, alpha-galactosidase A, arylsulfatase A, and alpha-iduronidase. One of the major Man-6-P glycoproteins was identified as palmitoyl protein thioesterase, which was not previously thought to be lysosomal. This finding raises important questions about the cellular location and function of palmitoyl protein thioesterase, mutations in which result in the neurodegenerative disorder, infantile neuronal ceroid lipofuscinosis.
Research on Optimal Design of LabVIEW Program (2009)

This article discusses the procedures in the LabVIEW programming process design and consideres some of the universal factors,such as performance,speed,memory usage,as well as procedures such as optimization measures.In the programming process,it also encountered some performance impact on the implementation of speed and resource use and other issues,and raised a number of solutions of these issues.
Recent Advances in Magnetic Levitation: A Biological Approach from Diagnostics to Tissue Engineering (2018)

The magnetic levitation technique has been utilized to orientate and manipulate objects both in two dimensions (2D) and three dimensions (3D) to form complex structures by combining various types of materials. Magnetic manipulation holds great promise for several applications such as self-assembly of soft substances and biological building blocks, manipulated tissue engineering, as well as cell or biological molecule sorting for diagnostic purposes. Recent studies are proving the potential of magnetic levitation as an emerging tool in biotechnology. This review outlines the advances of newly developing magnetic levitation technology on biological applications in aqueous environment from the biotechnology perspective.
Detection of hepatitis C virus RNA in peripheral blood mononuclear cells of infected patients by in situ hybridization (1994)

We used in situ hybridization to detect hepatitis C virus (HCV) infection of peripheral blood mononuclear cells (PBMNC) from 11 patients with chronic active hepatitis. Using 35S-labeled HCV-RNA probe, HCV-RNA-positive and -negative strands were observed in unstimulated PBMNC from three patients, all of whom were receiving immunosuppressive drugs after orthotopic liver transplantation (OLT). HCV-RNA sequences were also identified in PBMNC from three patients who were not undergoing immunosuppression, after stimulation with either phytohemagglutinin (PHA) or pokeweed mitogen (PWM). In contrast, HCV- RNA was not found in the remaining five patients, who had not undergone OLT and whose cells were not stimulated with mitogens. These results show that mononuclear cells can be infected by HCV and that mitogenic stimulation of infected cells increases HCV-RNA replication.
Acoustics 1994: Vibrations and acoustical response of fuzzy structures (1995)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation D. Feit, A. D. Pierce; Acoustics 1994: Vibrations and acoustical response of fuzzy structures. J Acoust Soc Am 1 January 1995; 97 (1): 705. https://doi.org/10.1121/1.412296 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAcoustical Society of AmericaThe Journal of the Acoustical Society of America Search Advanced Search |Citation Search
The centipede high-power traveling-wave tube (1960)

An S-band high power traveling-wave tube using a loop-coupled structure has been designed and tested. This structure, called the 'centipede, was first suggested by Chodorow and Craig. The coupling between adjacent cavities is provided by means of several loops in each section. The tube characteristics are similar to the well-known cloverleaf with respect to high voltage and high peak power operation. The tube will be described and the test results presented. The first model of the centipede has the following characteristics: a saturated half-power bandwidth of approximately 500 Mc centered at 2900 Mc (or about 18 percent); a peak output power of 3 megawatts; a peak efficiency of 30 percent; and a saturated gain of approximately 26 db. The operating voltages ranged from 100 to 130 \times 10^{-6} kv with a beam perveance of 1.66 \times 10^{3} . Design changes and test results of later models of the tube will also be presented.