gebhart/patrepeval huggingface dataset:
Evaluation of Two Homologous Proline-Rich Proteins of <i>Coccidioides posadasii</i> as Candidate Vaccines against Coccidioidomycosis (2007)

Evaluation of the protective efficacy of recombinant T-cell-reactive proteins of Coccidioides posadasii in a murine model of coccidioidomycosis has led to the discovery of potential vaccines against this respiratory disease. A recombinant proline-rich antigen (rAg2/Pra) has been reported to be a leading vaccine candidate. However, contradictory results exist on the protection afforded by this antigen. Subcutaneous vaccination of either C57BL/6 or BALB/c mice with rAg2/Pra plus adjuvant followed by intraperitoneal challenge with C. posadasii resulted in a significant reduction of the fungal burden at 12 to 14 days postchallenge compared to that in nonvaccinated animals. Use of the same vaccination protocol followed by intranasal (i.n.) challenge of C57BL/6 mice with an equal number of organisms culminated in chronic pulmonary infection or death over a 90-day period. Early studies of Ag2/Pra suggested that it is a component of an immunogenic complex. We reveal in this study that C. posadasii produces a homolog of the reported proline-rich antigen, designated Prp2, which shows 69% protein sequence identity and 86% similarity to Ag2/Pra. Protection against i.n. challenge of C57BL/6 mice was evaluated by vaccination with the single bacterially expressed homolog, rAg2/Pra, or rPrp2 in combination with rAg2/Pra, each in the presence of the same adjuvant. The combined vaccine provided significantly better protection than either of the single recombinant protein vaccines. Results of enzyme-linked immunospot assays of the immunized mice revealed that the two proline-rich homologs contain unique T-cell epitopes. In combination, the recombinant proteins stimulate a more heterogeneous and protective T-cell repertoire than the monovalent vaccines.
Image-guided, direct convective delivery of glucocerebrosidase for neuronopathic Gaucher disease (2006)

Convection-enhanced delivery can be used to safely perfuse large regions of the brain and brainstem with therapeutic levels of glucocerebrosidase. Co-infused imaging surrogate tracers can be used to monitor and control the distribution of therapeutic agents in vivo. Patients with neuronopathic Gaucher disease and other intrinsic CNS disorders may benefit from a similar treatment paradigm.
A Clustering-based Sales Forecasting Scheme Using Support Vector Regression for Computer Server (2015)

In this study, a clustering-based sales forecasting scheme based on support vector regression (SVR) is proposed. The proposed scheme first uses k-means algorithm to partition the whole training sales data into several disjoint clusters. Then, for each group, the SVR is applied to construct forecasting model. Finally, for a given testing data, three similarity measurements are used to find the cluster which the testing data belongs to and then employee the corresponding trained SVR model to generate prediction result. A real aggregate sales data of computer server is used as an illustrative example to evaluate the performance of the proposed model. Experimental results revealed that the proposed clustering-based sales forecasting scheme outperforms the single SVR without data clustering and hence is an effective alternative for computer server sales forecasting.
2-Aminothiazoles as Therapeutic Leads for Prion Diseases (2011)

2-Aminothiazoles are a new class of small molecules with antiprion activity in prion-infected neuroblastoma cell lines (J. Virol. 2010, 84, 3408). We report here structure-activity studies undertaken to improve the potency and physiochemical properties of 2-aminothiazoles, with a particular emphasis on achieving and sustaining high drug concentrations in the brain. The results of this effort include the generation of informative structure-activity relationships (SAR) and the identification of lead compounds that are orally absorbed and achieve high brain concentrations in animals. The new aminothiazole analogue (5-methylpyridin-2-yl)-[4-(3-phenylisoxazol-5-yl)-thiazol-2-yl]-amine (27), for example, exhibited an EC(50) of 0.94 μM in prion-infected neuroblastoma cells (ScN2a-cl3) and reached a concentration of ∼25 μM in the brains of mice following three days of oral administration in a rodent liquid diet. The studies described herein suggest 2-aminothiazoles as promising new leads in the search for effective therapeutics for prion diseases.
Thrust-Matching Requirements for the Conceptual Design of Hypersonic Waverider Vehicles (2005)

A methodology is presented that integrates a Turboramjet and Scramjet with a conically-derived waverider airframe to achieve sustained hypersonic flight. The performance of each engine is calculated and a smooth transition between the two types of powerplant is achieved by matching their thrust and specific impulse at the appropriate Mach number regime. Both the Scramjet and Turboramjet are analytically modelled. The waverider is generated using a streamline tracing technique forward of the inlet plane. The two-dimensional method of characteristics is used to generate the nozzle flowfield. Propulsion / airframe integration issues are discussed with a description of the inlet arrangement. The viscous forces are predicted using a reference temperature technique and a maximum lift-to-drag ratio, (L/D), waverider is selected using constraint analysis. Results are presented with a Turboramjet operating from static to Mach 5, at Turboramjet / Scramjet transition speeds and with a scramjet while constant altitude acceleration at 30km to Mach 9. A Mach 10 waverider was shown to generate a maximum value of L/D = 7.8
Preparation and characterization of low-dielectric-constant F-doped SiOCN films by PECVD (2010)

F-doped SiOCN films with low dielectric constant have been prepared using SiH <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> , C <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> F <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sub> and N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O as reactants by PECVD, and characterized by X-ray photoelectron spectroscopy (XPS), capacitance -voltage (C-V) and current-voltage (I-V) measurements, and nano-indenter. With an increment of the flow rate of C <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> F <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sub> , the concentrations of fluorine and carbon incorporated in the films increase, and the concentration of nitrogen decreases. This leads to a decrease in the dielectric constant of the film. When the flow rate of C <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> F <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sub> is 750 sccm, the percentages of C and F elements amount to 5.2% and 9.9%, respectively. Meanwhile, the resulting dielectric constant is reduced to 2.6, and the leakage current density is lower than 3× 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-8</sup> A/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> at 1MV/cm. The hardness and Young's modulus of the films are higher than 3 GPa and 84 GPa, respectively. It is thus believed that the introduction of carbon and fluorine can lower the dielectric constant of the films, and the presence of N can improve the mechanical properties of film.
The First Optically Pure <i>n</i><i>ido</i>-Monothiocarborane Cluster (1999)

One of the enantiomers of racemic [NMe4][7-SPh-8-CH2OH-7,8-C2B9H10] is isolated in 68% yield. Resolution is achieved by means of differential crystallization of the diastereoisomeric camphanate ester derivatives.
Multiplexed and distributed control of automated welding (1994)

Although modern sensor technology and control algorithms have enabled in-process regulation of arc welding, classical single-torch actuation methods provide only a few welding conditions that can be modulated in real time to control multiple weld geometry characteristics. To decouple the process dynamics and simultaneously control thermal characteristics of the weld, multiple virtual heat inputs are implemented by rapid periodic reciprocation (timesharing) of the single torch on the weld surface. Dynamic analytical, numerical and linearized experimental process models are developed for the design of adaptive MIMO control systems of both geometrical and thermal characteristics, and their performance is tested in rejecting disturbances and following setpoint changes. To maximize the range of achievable weld features, a continuous heat distribution and temperature monitoring on the entire weld surface is finally adopted. The necessary vector-scanning trajectories of the torch are regulated in real time by a distributed-parameter control strategy, integrated to the weld design software for flexibility in production.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Mössbauer Effect in the System SrFeO2.5–3.0 (1964)

Mössbauer spectra were measured at 4°, 78°, and 300°K for the two end members and two intermediate samples of the system SrFeO2.5–3.0. Of primary interest is the spectrum of strontium ferrate (IV) which at 300°K consists of a single unsplit line having a full width at half-intensity of 0.39 mm/sec and an isomer shift relative to copper of —0.171 mm/sec. At 4° and 78°K the spectra consist of six lines with an ISCu of —0.079 mm/sec and an hfs of 331 and 290 kOe, respectively. There is no evidence of quadrupole splitting, consistent with the cubic perovskite structure. The spectra of the pure iron (III) compound are composed of two sets of six-line spectra having ISCu of +0.126 and —0.047 mm/sec and hfs of 489 and 407 kOe, respectively, at 300°K. By analogy with YIG, it was concluded that the structure should contain equivalent amounts of octahedrally and tetrahedrally coordinated iron sites. Subsequent structural analysis confirmed this conclusion and indicated that the phase is isomorphic with brownmillerite. The spectra of the intermediate compounds were found to be more complex and are discussed in terms of accompanying changes in stoichiometry and structure.
All‐Cellulose (Cellulose–Cellulose) Green Composites (2018)

This chapter contains sections titled: Introduction Preparation of ACCs Structures and Properties of ACCs Future Prospects Summary Acknowledgements
Oscillations in the NF-kB signalling pathway. (2009)

NF-κB oscillations were suggested by Hoffmann et al from electro-mobility shift assays (EMSA) in population studies of IκBα-/- embryonic fibroblasts and simulated in a computational model. NF-κB oscillations were also observed by Nelson et al at the single cell level. The Hoffmann model gave a fairly good pre- diction of Nelson et al oscillatory experimental data using fluorescent proteins. A common comment on the source of oscillations is the existence of negative feedback loops. Just from the point of mathematics, we can set up a simple system containing a negative feedback loop that possesses oscillating behaviour resembling the ones observed in the experiments like Fonslet et al did. However, different models with similar structures can have dramatically different dynam- ical behaviour. In order to understand biological mechanisms, it is necessary to work on those real models that are based on experimental data even though models may be very large. In this paper, we are able to analyze the dynamical properties of Hoffmann’s large computational model (containing 24 variables and 64 parameters) by using computational and analytical methods and give an explanation of the source of oscillations. We find that the computational model can be treated as a fast-slow system where the level of total IκB Kinase (IKK) is treated as a slow variable. If we consider the limit in which the level of total IKK does not change at all, then we can take the level of total IKK as a parameter. Since the total NF-κB is conserved in the model, we can also view the total NF-κB as a parameter. If the actual variation of IKK is sufficiently slow, then orbits in the true system trace attractors in the reduced model. We find that for some range of the level of NF-κB, the reduced system experiences Hopf bifurcation twice while varying the level of total IKK. The damped oscillations observed in the computational system come from the existence of stable limit cycles and stable spirals in the reduced system family.
Development of polymer membranes for 157-nm lithography (2004)

Fluoropolymers were/are successfully used for pellicle manufacturing in 248 and 193 nm lithography. However, all known fluoropolymers rapidly degrade when exposed to high-energy 157 nm irradiation. Lack of suitable polymer “soft” pellicle has become one of the major obstacles for implementing 157 nm lithography. The goal of this research was to investigate the photodegradation mechanisms in fluoropolymers under 157 nm irradiation using various analytical techniques, and establish correlation between polymer structure and transparency/durability. Various polymer platforms, developed by Asahi Glass Corporation, as well as model polymer based on industrially available materials, have been employed in this study. Polymer structures have been analyzed using solution NMR, FTIR, Raman spectroscopy, TOF-SIMS, nanoindentation, outgassing, contact angle, ellipsometry, refractometry, n and k measurements. Transparency and durability of polymer membranes under 157 nm irradiation were established using an F<sub>2</sub> 157 nm laser as a source of irradiation, and an environmentally controlled chamber. As the result of this study, photodegradation mechanism for some of the tested polymers was tentatively suggested as cleavage of carbonyl, CO, and/or CFO bonds. Additionally, the following general conclusions have been made: environmental moisture, gas environment, and polymer/adhesive solvents affect structure and durability of the exposed polymers; “skin” surface layer can be formed on the surface of the irradiated polymer; polymer membranes are thinning under 157 nm irradiation; polar groups are formed on the irradiated surface. Effects of gas environment, exposure conditions, technology of the sample preparation on the photodegradation mechanism and kinetics were studied. Possible photodegradation pathways have been derived and assessed. Dependence of polymer durability and transparency on such structural features as number of carbon atoms within the ring, oxygen content, type and number of substituents in the Oxygen containing perfluorinated rings, number and location of carbon-oxygen bonds, structure symmetry, relative ratio of cyclic and linear chains, content and type of the hydrogen bonds, were analyzed. Semi-empirical rules to optimize transparency, durability, and mechanical properties of polymer membranes for 157nm exposure, will be discussed.
Association of Periodontal Disease and Histologic Lesions in Multiple Organs from 45 Dogs (1996)

Forty-five mixed breed dogs were evaluated for the presence and extent of periodontal disease. Histopathology was performed on samples of lung, myocardium, liver, kidney, tonsil, spleen, submandibular lymph node and tracheobronchial lymph node. Mitral valves were evaluated grossly. Statistical analysis was used to determine if there was a relationship between the extent of periodontal disease and histopathologic changes in the tissues examined. In the forty-five dogs studied, an association was found between periodontal disease and histopathologic changes in kidney, myocardium (papillary muscle), and liver.
<title>Methods for CCD camera characterization</title> (1994)

In this paper we present methods for characterizing CCD cameras. Interesting properties are linearity of photometric response, signal-to-noise ratio, sensitivity, dark current, and spatial frequency response. The techniques to characterize CCD cameras are carefully designed to assist one in selecting a camera to solve a certain problem. The methods described were applied to a variety of cameras: an Astromed TE3/A with P86000 chip, a Photometrics CC200 series with Thompson chip TH7882, a Photometrics CC200 series with Kodak chip KAF1400, a Xillix' Micro Imager 1400 with Kodak chip KAF1400, an HCS MXR CCD with a Philips chip and a Sony XC-77RRCE.
Scalable distributed subgraph enumeration (2016)

Subgraph enumeration aims to find all the subgraphs of a large data graph that are isomorphic to a given pattern graph. As the subgraph isomorphism operation is computationally intensive, researchers have recently focused on solving this problem in distributed environments, such as MapReduce and Pregel. Among them, the state-of-the-art algorithm, Twin TwigJoin, is proven to be instance optimal based on a left-deep join framework. However, it is still not scalable to large graphs because of the constraints in the left-deep join framework and that each decomposed component (join unit) must be a star. In this paper, we propose SEED - a scalable sub-graph enumeration approach in the distributed environment. Compared to Twin TwigJoin, SEED returns optimal solution in a generalized join framework without the constraints in Twin TwigJoin. We use both star and clique as the join units, and design an effective distributed graph storage mechanism to support such an extension. We develop a comprehensive cost model, that estimates the number of matches of any given pattern graph by considering power-law degree distribution in the data graph. We then generalize the left-deep join framework and develop a dynamic-programming algorithm to compute an optimal bushy join plan. We also consider overlaps among the join units. Finally, we propose clique compression to further improve the algorithm by reducing the number of the intermediate results. Extensive performance studies are conducted on several real graphs, one containing billions of edges. The results demonstrate that our algorithm outperforms all other state-of-the-art algorithms by more than one order of magnitude.
Temporally consistent caption detection in videos using a spatiotemporal 3D method (2009)

Captions are text or logos superimposed on videos during a postproduction process. Caption detection in videos is useful for a variety of applications. For many applications, temporal consistency and stability is very important. Most of the prior work adopts certain post-processing procedures to smooth detected caption bounding boxes over time. Although these approaches mitigate the effect of the temporal inconsistency problem, they are unable to eliminate the problem. In this paper, we present a new caption detection algorithm that detects the 3D bounding boxes of caption regions in spatiotemporal volume space. 2D bounding boxes are then created by slicing the 3D bounding boxes. Since all the 2D bounding boxes corresponding to a caption area are sliced from one 3D bounding box, they are identical over time, thus ensuring temporal consistency of the result. The experiment results show that our new approach not only generates temporally consistent results but also results in higher detection accuracy.
A self-assembling peptide reduces glial scarring, attenuates post-traumatic inflammation and promotes neurological recovery following spinal cord injury (2013)

The pathophysiology of spinal cord injury (SCI) involves post-traumatic inflammation and glial scarring which interfere with repair and recovery. Self-assembling peptides (SAPs) are molecules designed for tissue engineering. Here, we tested the performance of K2(QL)6K2 (QL6), a SAP that attenuates inflammation and glial scarring, and facilitates functional recovery. We injected QL6 into the spinal cord tissue of rats 24 h after clip compression SCI. QL6 led to a significant reduction in post-traumatic apoptosis, inflammation and astrogliosis. It also resulted in significant tissue preservation as determined by quantitative histomorphometry. Furthermore, QL6 promoted axonal preservation/regeneration, demonstrated by BDA anterograde and Fluorogold retrograde tracing. In vitro experiments found that a QL6 scaffold enhanced neuronal differentiation and suppressed astrocytic development. The electrophysiology confirmed that QL6 led to significant functional improvement of axons, including increased conduction velocity, reduced refractoriness and enhanced high-frequency conduction. These neuroanatomical and electrophysiological improvements were associated with significant neurobehavioral recovery as assessed by the Basso-Beattie-Bresnahan technique. As the first detailed examination of the pathophysiological properties of QL6 in SCI, this work reveals the therapeutic potential of SAPs, and may suggest an approach for the reconstruction of the injured spinal cord.
Blood Screening for Phenylketonuria (1961)

<h3>To the Editor:—</h3> Since the discovery by Fölling, in 1935, of phenylketonuria (PKU), the simple ferric chloride test of urine has been the universal method of detecting this disease in spite of serious limitations. These include (1) failure of young infants to produce a positive test until several weeks after birth, even though there is evidence that blood phenylalanine concentration increases rapidly in the first few days of life in this condition (Armstrong<i>et al., Proceedings of the Third International Neurochemical Symposium,</i>1958, to be published) and (2) failure of older PKU cases to produce a positive ferric chloride test if blood phenylalanine levels are below approximately 20 mg. per cent. Obviously a simple method of detecting elevated phenylalanine blood levels should overcome these limitations. Recently, with the cooperation of Dr. William Welch, Director of the Laboratory at Newark State School, Newark, N.Y., we have had the opportunity to develop
New Left, New Right, and the Legacy of the Sixties. (1997)

Journal Article New Left, New Right, and the Legacy of the Sixties. By Paul Lyons. (Philadelphia: Temple University Press, 1996. xiv, 242 pp. Cloth, $54.95, ISBN 1-56639-477-5. Paper, $19.95, ISBN 1-56639-478-3.) Get access Michael S. Foley Michael S. Foley University of New Hampshire, Durham, New Hampshire Search for other works by this author on: Oxford Academic Google Scholar Journal of American History, Volume 84, Issue 2, September 1997, Pages 738–739, https://doi.org/10.2307/2952720 Published: 01 September 1997