gebhart/patrepeval huggingface dataset:
Combined effect of total nucleated cell dose and HLA match on transplantation outcome in 1061 cord blood recipients with hematologic malignancies (2009)

Both total nucleated cell (TNC) dose and human leukocyte antigen (HLA)-match affect the outcome of cord blood (CB) transplantation. However, how to prioritize these characteristics in unit selection is not established. Therefore, we analyzed the outcomes of 1061 patients who received single-unit myeloablative CB transplantation for leukemia or myelodysplasia. TNC dose and HLA-match each affected survival via their effect on transplant-related mortality (TRM); neither was associated with relapse. Therefore, TRM was the focus of multivariate analyses combining dose and HLA-match. Compared with our 1 HLA-mismatch (MM) reference group with TNC 2.5 to 4.9 x 10(7)/kg, recipients of 0 MM units had the lowest TRM regardless of dose (relative risk [RR] = 0.4, P = .019). TRM for recipients of 1- or 2-MM units with TNC 5.0 x 10(7)/kg or greater was similar to the reference group (RR = 0.8, P = .391 and RR = 1.0, P = .847) despite their greater dose. Recipients of 2 MM units with TNC 2.5 to 4.9 x 10(7)/kg had a greater TRM (RR = 1.5, P = .014), and those with 1 or 2 MM and TNC less than 2.5 x 10(7)/kg or 3 MM did substantially worse. These findings support new unit selection criteria that take into account both TNC dose and HLA-match and have important implications for the size of the global CB inventory needed to find an optimum CB graft.
[5-(Adenin-9-yl)-5-deoxypentofuranosyl]phosphonates - A Novel Type of Nucleotide Analogs Related to HPMPA. I. Derivatives with L-arabino, D-arabino, 2-Deoxy-L-erythro and 2-Deoxy-L-threo Configuration (1993)

[5-(Adenin-9-yl)-5-deoxypentofuranosyl]phosphonates, a new type of nucleotide analogs with fixed HPMPA structure, have been prepared. The synthesis of compounds of L- arabino ( IIa, IIb ), D- arabino ( XIVa, XIVb ), 2-deoxy-L- erythro ( IIIa, IIIb ) and 2-deoxy-L- threo ( IVa, IVb ) configuration is based on the Michelis-Arbuzov reaction of the fully protected methyl glycosides with triethyl phosphite and trimethylsilyl triflate which leads to anomeric mixture of diethyl (L-pentofuranosyl) phosphonates. The protected 5- O -tosyl derivatives react with sodium salt of adenine to give N 9 -substituted products which after total deprotection afforded the tittle nucleotide analogs. The fixation of the partial structure of HPMPA to form five-membered ring leads to a significant decrease, or a total loss, of biological activity.
Posttranslational Modification of Brain Tubulins from the Antarctic Fish <i>Notothenia coriiceps</i>:  Reduced C-Terminal Glutamylation Correlates with Efficient Microtubule Assembly at Low Temperature (2004)

We have shown previously that the tubulins of Antarctic fish assemble into microtubules efficiently at low temperatures (-2 to +2 degrees C) due to adaptations intrinsic to the tubulin subunits. To determine whether changes in posttranslational glutamylation of the fish tubulins may contribute to cold adaptation of microtubule assembly, we have characterized C-terminal peptides from alpha- and beta-tubulin chains from brains of adult specimens of the Antarctic rockcod Notothenia coriiceps by MALDI-TOF mass spectrometry and by Edman degradation amino acid sequencing. Of the four fish beta-tubulin isotypes, nonglutamylated isoforms were more abundant than glutamylated isoforms. In addition, maximal glutamyl side-chain length was shorter than that observed for mammalian brain beta tubulins. For the nine fish alpha-tubulin isotypes, nonglutamylated isoforms were also generally more abundant than glutamylated isoforms. When glutamylated, however, the maximal side-chain lengths of the fish alpha tubulins were generally longer than those of adult rat brain alpha chains. Thus, Antarctic fish adult brain tubulins are glutamylated differently than mammalian brain tubulins, resulting in a more heterogeneous population of alpha isoforms and a reduction in the number of beta isoforms. By contrast, neonatal rat brain tubulin possesses low levels of glutamylation that are similar to that of the adult fish brain tubulins. We suggest that unique residue substitutions in the primary structures of Antarctic fish tubulin isotypes and quantitative changes in isoform glutamylation act synergistically to adapt microtubule assembly to low temperatures.
Slow eroding biodegradable multiblock poloxamer copolymers (2005)

Abstract Biodegradable multiblock poloxamers (BMPs) with gel duration of 8 h to several weeks were prepared by varying their molecular weights from 4000 to 40 000 g mol −1 . The molecular weight of the BMP was controlled by changing the poloxamer to coupling agent ratio. Assuming a micelle packing model of the BMP gel, as in the case of a poloxamer gel, the micelle properties and critical gel concentration of BMPs were investigated on the basis of the scaling concept. The findings suggest that the control of molecular weight by hydrolyzable groups can be a facile approach to optimize the gel properties for biomedical applications. Copyright © 2005 Society of Chemical Industry
Aspect of voltage stability and reactive power support in active distribution (2013)

In this study, the aspects of voltage stability related to voltage control and reactive power support in an active distribution grid are analysed, considering both static and dynamic system constrains. The analysis is carried out based on different international and local utility standards for voltage source converters (VSCs) and distribution. The ability of VSCs to provide reactive power support is explored in a structural way to improve voltage stability as well as power quality. The functional requirements of the VSCs are identified for this purpose in a generalised platform with the assumption of extension of the network automation till the distributed resources level. The step‐by‐step formulation of voltage stability and reactive power support requirements from system level are translated to VSC level for both static and dynamic system operation, aiming for a better system performance and new energy market scenario. The opportunity of tariff benefit would attract the DG operators as well as the customer for participating in system security through reactive power support and voltage profiling. The main contribution of the study lies in providing a comprehensive guideline for voltage control and reactive support of VSC interfaced DGs in active distribution combining the static and dynamic limitations.
Polymorphisms of the genes encoding the GSTM1, GSTT1 and GSTP1 in Korean women: no association with endometriosis (2004)

Endometriosis, one of the most common gynaecologic disorders, shows significantly elevated prevalence in industrial areas and there is also a possible genetic predisposition. Glutathione-S-transferases (GSTs) are enzymes involved in the metabolism of many disease-causing carcinogens and mutagens that are present in human environments. An association between the incidence of endometriosis and the GST genotypes of patients has been suggested. The objective of the present study was to investigate whether the polymorphisms of GSTM1, GSTT1 and GSTP1 are related to endometriosis. Blood samples were available from 259 controls and 194 patients with advanced endometriosis diagnosed by both pathology and laparoscopic findings. The proportion of the GSTM1, GSTT1 and GSTP1 genotypes of the control group were comparable to other populations. There was no significant evidence that the distribution of the GSTM1 and GSTT1 genotype differed between the patients and the controls, with an allelic odds ratio (OR)=1.074 [95% confidence interval (CI)=0.737-1.564] and 1.239 (95% CI = 0.853-1.799), respectively. Also, there was no significant difference in the proportion of GSTP1 genotypes between the women with endometriosis and the control group with the OR = 0.823 (95% CI = 0.536-1.264). The higher risk alleles were contended as GSTM1, GSTT1 null mutation and GSTP1 Ile105Ile polymorphism. There was no significant increase in the risk of endometriosis as the number of higher risk alleles of the GST family increased. In conclusion, our findings suggest that the GSTM1, GSTT1 and GSTP1 genetic polymorphisms are not associated with the development of endometriosis in Korean women.
Auction design for spectrum allocation under interference constraints (2013)

This paper introduces Truthful Multichannel Auction (TMCA), an auction design for the allocation of wireless channels to several bidders with private information about their channel valuation. Channel allocations are subject to interference constraints in the form of a conflict graph. In contrast to other channel auctions, TMCA allows for variable (instead of fixed) marginal valuations. In TMCA, it is a dominant strategy for bidders to truthfully reveal their channel valuations, which in turn guarantees the implementation of highly efficient allocations in polynomial time. This paper also shows the expected revenue of the auctioneer can be maximized by imposing a reserve price.
Cloning of a Second Type of Activin Receptor and Functional Characterization in <i>Xenopus</i> Embryos (1992)

A complementary DNA coding for a second type of activin receptor (ActRIIB) has been cloned from Xenopus laevis that fulfills the structural criteria of a transmembrane protein serine kinase. Ectodermal explants from embryos injected with activin receptor RNA show increased sensitivity to activin, as measured by the induction of muscle actin RNA. In addition, injected embryos display developmental defects characterized by inappropriate formation of dorsal mesodermal tissue. These results demonstrate that this receptor is involved in signal transduction and are consistent with the proposed role of activin in the induction and patterning of mesoderm in Xenopus embryos.
Global Optimization of Compositional Systems (2007)

Embedded systems typically consist of a composition of a set of hardware and software IP modules. Each module is heavily optimized by itself. However, when these modules are composed together, significant additional opportunities for optimizations are introduced because only a subset of the entire functionality is actually used. We propose COSE-a technique to jointly optimize such designs. We use symbolic execution to compute invariants in each component of the design. We propagate these invariants as constraints to other modules using global flow analysis of the composition of the design. This captures optimizations that go beyond, and are qualitatively different than, those achievable by compiler optimization techniques such as common subexpression elimination, which are localized. We again employ static analysis techniques to perform optimizations subject to these constraints. We implemented COSE in the Metropolis platform and achieved significant optimizations using reasonable computational resources.
Solvent Refining of Low Temperature Tar with Paraffinic Solvents (1960)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolvent Refining of Low Temperature Tar with Paraffinic SolventsM. D. Kulik and M. B. NeuworthCite this: Ind. Eng. Chem. 1960, 52, 2, 141–144Publication Date (Print):February 1, 1960Publication History Published online1 May 2002Published inissue 1 February 1960https://pubs.acs.org/doi/10.1021/ie50602a030https://doi.org/10.1021/ie50602a030research-articleACS PublicationsRequest reuse permissionsArticle Views40Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Improved Eco-Friendly Recombinant <i>Anabaena</i> sp. Strain PCC7120 with Enhanced Nitrogen Biofertilizer Potential (2010)

Photosynthetic, nitrogen-fixing Anabaena strains are native to tropical paddy fields and contribute to the carbon and nitrogen economy of such soils. Genetic engineering was employed to improve the nitrogen biofertilizer potential of Anabaena sp. strain PCC7120. Constitutive enhanced expression of an additional integrated copy of the hetR gene from a light-inducible promoter elevated HetR protein expression and enhanced functional heterocyst frequency in the recombinant strain. The recombinant strain displayed consistently higher nitrogenase activity than the wild-type strain and appeared to be in homeostasis with compatible modulation of photosynthesis and respiration. The enhanced combined nitrogen availability from the recombinant strain positively catered to the nitrogen demand of rice seedlings in short-term hydroponic experiments and supported better growth. The engineered strain is stable, eco-friendly, and useful for environmental application as nitrogen biofertilizer in paddy fields.
Generating intelligent numerical answers in a question-answering system (2006)

In this paper, we present a question-answering system on the Web which aims at generating intelligent answers to numerical questions. These answers are generated in a cooperative way: besides a direct answer, comments are generated to explain to the user the variation of numerical data extracted from the Web. We present the content determination and realisation tasks. We also present some elements of evaluation with respect to end-users.
Production and Characterization of Monoclonal Antibodies to Budgerigar Fledgling Disease Virus Major Capsid Protein VP 1 (1992)

Eleven hybridoma cell lines producing monoclonal antibodies (MAbs) against intact budgerigar fledgling disease (BFD) virions were produced and characterized. These antibodies were selected for their ability to react with BFD virions in an enzyme-linked immunosorbent assay. Each of these antibodies was reactive in the immunofluorescent detection of BFD virus-infected cells. These antibodies immunoprecipitated intact virions and specifically recognized the major capsid protein, VP1, of the dissociated virion. The MAbs were found to preferentially recognize native BFD virus capsid protein when compared with denatured virus protein. These MAbs were capable of detecting BFD virus protein in chicken embryonated cell-culture lysates by dot-blot analysis.
A 10-bit current-mode low-power CMOS A/D converter with a current predictor and a modular current reference (2002)

This paper describes a 10-bit CMOS current-mode ADC with a current predictor and a modular current reference circuits. A current predictor and a modular current reference are employed to reduce the number of comparators and reference current mirrors and consequently to decrease a power dissipation. The simulation result shows a conversion rate of 10 M samples/s and a power dissipation of 110 mW.
Automatic Development of an Abstract Context Model for an Intelligent Environment (2005)

This paper addresses the problem of learning in intelligent environments. An intelligent environment perceives user activity and offers a number of services according to the perceived information about the user. An abstract context model in the form of a situation network is used to represent the intelligent environment, its occupants and their activities. The objective is to adapt the system services, which are associated to the situations of the model, to the changing needs of the user. For this, a supervisor gives feedback by correcting system services that are found to be inappropriate to user needs. The situation network can be developed by exchanging the system service-situation association or by splitting the situation. The situation split is interpreted as a replacement of the former situation by sub-situations whose number and characteristics are determined using conceptual or decision tree algorithms. Different algorithms have been tested on a context model within the SmartOffice environment of the PRIMA research group. The decision tree algorithm (ID3) has been found to give the best results.
Detecting identifiable areas in mobile environments (2006)

Location-based applications and services are getting increasingly important for mobile users. They take into account a mobile user's current location and provide a location-dependent output. To support developers of location-based services, the Nimbus framework hides specific details of positioning systems and provides uniform output containing physical as well as symbolic location information, which often are more suitable for applications and users. One basic problem solved by Nimbus is the Distributed Location Resolution Problem: given a location; which identifiable areas cover this location, if the area information is distributed among different servers. This paper presents a solution of this problem that runs in the distributed, self-organizing Nimbus infrastructure. The effectiveness is demonstrated with the help of performance analyses.
Applications of Digital PCR for Clinical Microbiology (2017)

Digital PCR (dPCR) is an important new tool for use in the clinical microbiology laboratory. Its advantages over quantitative PCR (qPCR), including absolute quantification without a standard curve, improved precision, improved accuracy in the presence of inhibitors, and more accurate quantitation when amplification efficiency is low, make dPCR the assay of choice for several specimen testing applications. This minireview will discuss the advantages and disadvantages of dPCR compared to qPCR, its applications in clinical microbiology, and considerations for implementation of the method in a clinical laboratory.
A compact planar multi-broad band monopole antenna for mobile devices (2015)

A Multiple-frequency broadband planar monopole antenna is proposed in this Paper. The antenna is stimulated and numerically optimized by HFSS13.0 (High Frequency Structure Simulator). The size of it is 39mm×22mm×1.7mm. The antenna resonates at many frequencies. The parameter S11≤-6dB means the proposed antenna matches well with its feed-line and covers many useful operation frequency bands, including 2G(DCS1800 and PCS1900), 3G(UMTS), 4G(LTE2300 and LTE2500), ISM, WLAN. It is quiet appropriate for the present ultra-thin smart phones
High Performance PAM Transmission Aided by Polar Code (2019)

A polar coded PAM system is experimentally demonstrated over 10-km transmission in C-band. Results show that 30.9 dB and 23.7 dB optical budgets are respectively achieved for 28-Gbaud PAM-4 and PAM-8 using 1 0-GHz DML.
Finding Maximum on an Array Processor with a Global Bus (1984)

The problem of finding the maximum of a set of values stored one per processor on an n X n array of processors is analyzed. The array has a time-shared global bus in addition to conventional processor-processor links. A two-phase algorithm for finding the maximum is presented that uses conventional links during the first phase and the global bus during the second. This algorithm is faster than algorithms that use either only the global bus or only the conventional links.
Zinc and Macular Degeneration (1992)

<h3>To the Editor.</h3> —During the past year, ophthalmologists have been subjected to an extensive publicity campaign regarding the role of micronutrients, especially zinc supplementation in the treatment of macular degeneration. The article by Newsome et al<sup>1</sup>in the February 1988 issue of theArchivesis often quoted to substantiate this advertising. In the study done by the authors, 200 mg of zinc was given daily to patients with macular degeneration. This is a toxic amount of zinc that can produce serious complications. The recommended daily allowance is 15 mg. When more than 150 mg of zinc is taken, it can produce serious copper deficiency, sideroblastic anemia, and bone marrow depression.<sup>2</sup>Such patients must often undergo costly and unpleasant tests, such as bone marrow biopsy, to determine the cause of the anemia. It is important for clinicians to be aware of this possible complication when prescribing large amounts of
Estructura arbórea del bosque tropical caducifolio usado parala ganadería extensiva en el norte de la Sierra de Manantlán,México. Antagonismo de usos (2002)

El bosque tropical caducifolio es uno de los bosques menos estudiados en México y es uno de los más diversos del mundo. La ganadería extensiva y el cambio de uso del suelo (de bosques a pastos) representan una presión importante para este bosque tropical, por lo que está considerado entre los más amenazados de los bosques tropicales del mundo. En este trabajo se analizan la estructura, la diversidad de especies y usos de las especies arbóreas del bosque tropical caducifolio del norte de la reserva de la Biosfera Sierra de Manantlán. Se seleccionaron cuatro áreas de bosque tropical caducifolio usadas por el ganado que corresponden a: un corredor de vegetación secundaria de 10 años, dos áreas de bosque de 15 y 20, y otro más con aproximadamente 30 años. Los datos de la vegetación se tomaron a través de muestreos aleatorios de punto cuadrante y entrevistas abiertas para los datos etnobotánicos. Concluimos que: 1) más del 80 por ciento de las especies arbóreas del bosque tropical caducifolio secundario de Zenzontla tienen al menos un uso, 2) la diversidad de especies (índice de Shannon-Wiener) de Zenzontla es mayor que otros tipos de vegetación de la Sierra de Manantlán, por ejemplo, bosque mesófilo de montaña, bosque de pino y bosque de pino-encino, 3) a través del tiempo, la diversidad de especies y de usos aumenta, 4) el número de individuos de especies con uso forrajero es menor que el número de individuos de especies con otros usos, y 5) la estructura de tamaños sugiere que, en el futuro, las especies no forrajeras podrían ser más dominantes que las forrajeras. La paradoja es que áreas importantes del bosque tropical caducifolio con especies de uso forrajero y otros usos (principalmente medicinal y alimenticio), presentan una fuerte presión debido a su eliminación total o parcial de estas áreas para ser sustituidas por pastizales.
Prolonged Survival of Pig Skin on Baboons After Administration of Pig Cells Expressing Human CD47 (2016)

Prolongation of transient porcine chimerism via transgenic expression of human CD47 in a primate model is associated with an immune modulating effect, leading to markedly prolonged survival of donor swine skin xenografts that may be applicable to clinical solid organ xenotransplantation.
Breakdown of gliadin peptides by intestinal brush borders from coeliac patients. (1984)

The 'missing peptidase' hypothesis to explain the aetiology of coeliac disease has never been satisfactorily resolved and recent reports suggest that coeliac brush borders may have depressed levels of specific peptidase enzymes. It has been inferred from these studies that the subsequent brush border digestion of gliadin peptides may therefore be defective. In this present study a sensitive fluorometric assay was used to measure the hydrolysis of a peptic-tryptic digest of gliadin by both normal and coeliac brush borders. The coeliac brush borders were as efficient as the normals in hydrolysing gliadin peptides and showed no depression of any specific peptidase activity.