gebhart/patrepeval huggingface dataset:
Scalable policy driven and general purpose public key infrastructure (PKI) (2002)

This paper describes a flexible and general purpose PKI platform. Providing an easily interoperable security infrastructure. Developed at AT&T Labs, the architecture is part of the UCAID/Internet2 efforts in PKI and scalable security. The architecture can host multiple certificate authorities (CAs) from different vendors in a uniform and scalable manner. This facilitates scalable operation with third-party CA systems. It acts as a CA distributor driven by uniform enrollment procedures based on vendor independent PKI policies. The design of seamless integration facilitates easy integration with third party CA services such as Verisign. The architecture adapts software components into a framework for secure, authenticated IP services over the open Internet or within internal intranets. Policy descriptions, written in XML, support explicit controls upon certificate sources and contents. These XML-encoded policies define issuance and acceptance of X.509v3 certificates from multiple CAs supporting the obligations and warrantees, even if the policy is neither recorded anywhere nor referenced in the certificate. The PKI component has been developed within a general middleware platform.
The economic impact of factor VIII inhibitors in patients with haemophilia (2004)

The impact on the cost of care for haemophilia patients with inhibitors is not well defined. To quantify the effect on health care expenditures associated with inhibitors to factor VIII (FVIII) or FIX, we conducted a retrospective cohort study examining product use and outcomes in adult and paediatric haemophilia patients with and without inhibitors. Twelve patients with inhibitors to FVIII or FIX (cases) identified in the haemophilia surveillance system (HSS) at two centres were matched on age, severity of haemophilia, and treatment centre to haemophilia patients without inhibitors. Patients with HIV or significant liver disease were excluded from the study. All eligible non-inhibitor control patients were selected for inclusion in the study, resulting in a total of 28 controls. We then tracked product usage and hospitalizations from programme entry until 1998 or loss to follow-up, producing a total database of 184 person-years of experience. A descriptive matched analysis was conducted to examine annual differences in the cost of product used and hospitalizations. We found that the median cost for factor products among haemophilia patients with inhibitors was $55,853/year, $2,760 less than comparable haemophilia patients without inhibitors. The median number of hospitalizations per year was 1.0 for both inhibitor and non-inhibitor patients and the median number of days hospitalized was virtually the same. Although these findings do not appear to support the belief that there is a substantial increase in the cost of care for haemophilia patients with inhibitors, it does document that a few outlier patients can drive the cost of treatment for this disease. As the largest component of the cost of care is that of factor concentrate, it becomes imperative in the current health care environment to better define the true costs and benefits of treatments designed to eradicate or manage inhibitors. A careful cost accounting of immune tolerance induction (ITI) and other therapeutic strategies, taking into account successes and failures and duration and intensity of therapy, should help to better define the costs and benefits of such approaches. Methods to identify high cost inhibitor patients should be developed so that these strategies may be targeted to appropriate candidates.
ChemInform Abstract: N‐Substituted β‐Aminoethylphosphonates. (1989)

Abstract The preparation of β‐aminoethylphosphonic acid derivatives is studied in detail.
Refolding of thermally unfolded soy proteins during the cooling regime of the gelation process: effect on gelation (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRefolding of thermally unfolded soy proteins during the cooling regime of the gelation process: effect on gelationSrinivasan DamodaranCite this: J. Agric. Food Chem. 1988, 36, 2, 262–269Publication Date (Print):March 1, 1988Publication History Published online1 May 2002Published inissue 1 March 1988https://pubs.acs.org/doi/10.1021/jf00080a007https://doi.org/10.1021/jf00080a007research-articleACS PublicationsRequest reuse permissionsArticle Views737Altmetric-Citations106LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
How Good Is the Quality of Health Care in the United States? (1998)

Studies over the past decade show that some people are receiving more care than they need, and some are receiving less. Simple averages from a number of studies indicate that 50 percent of people received recommended preventive care; 70 percent, recommended acute care; 30 percent, contraindicated acute care; 60 percent, recommended chronic care; and 20 percent, contraindicated chronic care. These studies strongly suggest that the care delivered in the United States often does not meet professional standards. Efforts to measure quality and report routinely on the results to the public at large would allow more definitive assessments of the status of the nation's health care and would enable us to single out the areas in need of improvement.
A NEW LABORATORY METHOD FOR EVALUATING OIL SPILL DISPERSANTS (1993)

ABSTRACT A new dispersant effectiveness test, named EXDET, was developed to address certain concerns associated with currently available laboratory dispersant effectiveness test procedures. This new procedure uses standard laboratory equipment (such as a Burrell Wrist-Action Shaker) and small volumes of water, oil, and chemical dispersant. Other features include the capabilities to mass balance the dispersed and non-dispersed oil, and to generate replicate data for statistical analysis. Details of the new procedure are presented and data at various test conditions illustrate features of the laboratory test method. Variables, such as dispersant/oil ratio, dispersant addition method, water salinity and oil/water ratio can readily be investigated for various crude oils and dispersants with the new method.
On the Fluid Dynamics of Adaptive Airfoils (1998)

Abstract This paper discusses issues and practical requirements for an adaptive wing in relation to currently available technology. Adaptive wings offer many benefits, but a viable wing will require research into several areas, including selection of initial and perturbed airfoil shapes, steady and unsteady aerodynamic analysis of adaptive airfoils, and methods for real-time shape control of an adaptive wing system. An overview of adaptive wing history is briefly covered, including some recent developments. Development considerations for an adaptive wing system are then discussed. Aerodynamic performance and stability should be considered in the context of the wing’s structural integrity and aeroelasticity. Particular attention should be paid to the unsteady nature of the flow, as standard quasi-steady flow analysis techniques should be abandoned due to the rapid changes in wing shape and motion. Due to the large number of variable and measured parameters, an advanced control system is required to relate the flight conditions with changes in geometry. Issues related to adapting wings to various aircraft scales will be discussed, specifically micro aerial vehicles (μAVs). unmanned aerial vehicles (UAVs or RPVs), full-scale aircraft, and ornithopters.
Designing scalable PGAS communication subsystems on cray gemini interconnect (2012)

The Cray Gemini Interconnect has been recently introduced as a next generation network architecture for building multi-petaflop supercomputers. Cray XE6 systems including LANL Cielo, NERSC Hopper, and the proposed NCSA Blue-Waters, as well as the Cray XK6 ORNL Titan leverage the Gemini Interconnect as their primary Interconnection network. At the same time, programming models such as the Message Passing Interface (MPI) and Partitioned Global Address Space (PGAS) models such as Unified Parallel C (UPC) and Co-Array Fortran (CAF) have become available on these systems. Global Arrays is a popular PGAS model used in a variety of application domains including hydrodynamics, chemistry and visualization. Global Arrays uses Aggregate Remote Memory Copy Interface (ARMCI) as the communication runtime system for Remote Memory Access (RMA) communication. This paper presents a design, implementation and performance evaluation of scalable and high performance communication ARMCI on Cray Gemini. The design space is explored and time-space complexities of communication protocols for one-sided communication primitives such as contiguous and uniformly non-contiguous datatypes, atomic memory operations (AMOs) and memory synchronization is presented. An implementation of the proposed design (referred as ARMCI-Gemini) demonstrates the efficacy on communication primitives, application kernels such as LU decomposition and applications such as Smooth Particle Hydrodynamics (SPH).
Etching Characteristics and Changes in Surface Properties of IGZO Thin Films by O2 Addition in CF4/Ar Plasma (2021)

Plasma etching processes for multi-atomic oxide thin films have become increasingly important owing to the excellent material properties of such thin films, which can potentially be employed in next-generation displays. To fabricate high-performance and reproducible devices, the etching mechanism and surface properties must be understood. In this study, we investigated the etching characteristics and changes in the surface properties of InGaZnO4 (IGZO) thin films with the addition of O2 gases based on a CF4/Ar high-density-plasma system. A maximum etch rate of 32.7 nm/min for an IGZO thin film was achieved at an O2/CF4/Ar (=20:25:75 sccm) ratio. The etching mechanism was interpreted in detail through plasma analysis via optical emission spectroscopy and surface analysis via X-ray photoelectron microscopy. To determine the performance variation according to the alteration in the surface composition of the IGZO thin films, we investigated the changes in the work function, surface energy, and surface roughness through ultraviolet photoelectron spectroscopy, contact angle measurement, and atomic force microscopy, respectively. After the plasma etching process, the change in work function was up to 280 meV, the thin film surface became slightly hydrophilic, and the surface roughness slightly decreased. This work suggests that plasma etching causes various changes in thin-film surfaces, which affects device performance.
Garbage collection software integrated with the system swapper in a virtual memory system (2002)

The authors have designed and implemented a modular Lisp interpreter for garbage collector evaluation. Data structures such as the list store, the hash table, the symbol table and the stacks were kept in separate modules with only the routines needed to handle them. Routines in other modules may only read and manipulate these data structures through the specified routines. Using this approach, when a garbage collector strategy or method of storing list cells is changed only the store module need be modified. Test programs and measurement strategies were designed for evaluating garbage collector performance in a virtual memory environment. Three garbage collectors have been coded and tested. They are a conventional link reversal marking garbage collector, a conventional recopying garbage collector, and a garbage collector integrated with the system swapper. The implementations are described and their performances are compared.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Chicken ovalbumin upstream promoter transcription factor binds to a negative regulatory region in the human immunodeficiency virus type 1 long terminal repeat (1991)

The human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR) contains a negative regulatory element (NRE) which downregulates the rate of LTR-directed transcription and HIV-1 replication. Within the NRE is a GGTCA palindrome, which binds a possible member of the steroid/thyroid hormone receptor superfamily. Mutation of this site leads to an increase in LTR-directed transcriptional activity compared with the wild type, consistent with the element's being a functional part of the NRE. The palindrome contains significant identity to the chicken ovalbumin upstream promoter (COUP) element to which COUP transcription factors (COUP-TFs), members of the steroid/thyroid hormone receptor superfamily, bind. We demonstrate here that human COUP-TFs can bind specifically to this HIV-1 COUP-like element in a manner identical to binding to ovalbumin COUP. We show that the predominant COUP-TF family member synthesized in T cells is the 68-kDa form, which is likely to be responsible for any in vivo function of the HIV-1 COUP-like element in these cells. Finally, we have identified three HIV-1 variant strains that contain mutations in the HIV-1 COUP-like element which affect the binding affinity of COUP-TF for these variant COUP elements.
Design for Collaboration in Mixed Reality: Technical Challenges and Solutions (2016)

One of the key challenges in the rapid technological advance of Virtual Reality (VR) and Mixed Reality (MR) concerns the design of collaborative experiences. VR systems do not readily support team collaboration because they tend to focus on individual experiences and do not easily facilitate naturalistic collaboration. MR environments provide solutions for collaborative experiences, but establishing smooth communication between hardware components and software modules faces a major hurdle. This paper presents the background to and main challenges of an ongoing project on collaboration in an MR lab, aiming to design a serious 'team collaboration' game. To this end, we utilized a common game engine to engineer a cost-effective solution that would make the game playable in a configuration operated by WorldViz and Volfoni equipment. Evaluation of various solutions in the development process found a Unity 3D Cluster Rendering Beta solution to be the most cost-effective and successful.
Enhancement of the 4 Transmit Antenna Rate 1 Space- Time Code for the OFDMA PHY (2004)

Release The contributor grants a free, irrevocable license to the IEEE to incorporate material contained in this contribution, and any modifications thereof, in the creation of an IEEE Standards publication; to copyright in the IEEE’s name an y IEEE Standards publication even though it may include portions of this contribution; and at the IEEE’s sole discr etion to permit others to reproduce in whole or in part the resulting IEEE Standards publication. The contributor als o acknowledges and accepts that this contribution may be made public by IEEE 802.16.
Neratinib (HKI-272), an irreversible pan erbB receptor tyrosine kinase inhibitor: phase 2 results in patients with advanced HER2+ breast cancer. (2009)

Abstract Abstract #37 Background: Neratinib (HKI-272) irreversibly inhibits the tyrosine kinase receptors, erbB1 (EGFR) and erbB2 (HER2). In a phase 1 study, neratinib was tolerable and demonstrated antitumor activity in patients (pts) with solid tumors, including 8 of 25 evaluable pts with erbB2-positive advanced breast cancer. In this open-label, 2-arm phase 2 study, pts with stage IIIB, IIIC or IV erbB2-positive advanced breast cancer were evaluated to further characterize the safety and efficacy of neratinib.&#x2028; Methods: ErbB2 gene amplification in tumor tissue, by FISH was a requirement for study entry. Pts were assigned to arm A if they had prior treatment with trastuzumab and to arm B if they had no prior treatment with trastuzumab or other erbB2-targeted drug. All pts received oral doses of 240 mg of neratinib daily. The primary endpoint was progression-free (PFS) survival rate at 16 weeks (wks).&#x2028; Results: Enrollment of 136 pts (arm A: 66 pts; arm B: 70 pts; median age 50 years [range 31-83 years]) was completed in November 2007. Common neratinib-related adverse events (AEs), any grade, were diarrhea (89%), nausea (29%), vomiting (23%), fatigue (16%), and anorexia (15%). Diarrhea was the only ≥grade 3 AE that occurred in ≥5% of pts, 26/136 (19%) total pts, 27% in arm A and 11% in arm B. Dose reductions occurred in 27% total pts, 36% in arm A and 19% in arm B, most commonly because of diarrhea. The main reasons for discontinuation of the study were disease progression (arm A: 74%, arm B: 43%), and AEs (arm A: 8%, arm B: 4%).&#x2028; 124 pts (arm A: 61 pts, arm B: 63 pts) were evaluable for efficacy based on independent assessment and 131 pts (arm A: 65 pts, arm B: 66 pts) were evaluable based on investigator assessment. The objective response rates (complete or partial response) were 26% (95% CI 16%, 39%) in arm A, 51% (95% CI: 38%, 64%) in arm B for independent assessment and 34% (95% CI: 23%, 47%) in arm A, 62% (95% CI: 49%, 74%) in arm B for investigator assessment. The 16-wk PFS rates were 61% in arm A, 75% in arm B (independent); 57% in arm A, and 78% in arm B (investigator). The median PFS for independent [and investigator assessment] was 23 [22] wks in arm A and 40 [35] wks in arm B.&#x2028; Discussion: Neratinib demonstrates robust antitumor activity in pts with erbB2-positive advanced breast cancer, with objective response rates of 26% in pts who had prior treatment with trastuzumab and 51% in pts who had no prior treatment with trastuzumab. Additional updated efficacy and safety data will be presented. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 37.
Preliminary Testing and Pilot-Scale Processing of the Kittson County Bloating Clays (1996)

iABSTRACT The Kittson County bloating clays are found in the northwest corner of Minnesota. The clays were deposited during two deep water phases of the Pleistocene Glacial Lake Agassiz, forming the Brenna Formation and part of the overlying Sherack Formation. Previous Natural Resources Research Institute (NRRI) studies detected the very lightweight, spherical, nature of these clays when fired. These studies have included bench scale firing tests, testing as lightweight aggregate in structural concrete, and development of a pelletization method to produce lightweight ceramic foam spheres. This current study moves testing of the clays to the pilot-plant stage, with collection of a bulk sample for rotary kiln firing and development of a processing flow sheet for the production of lightweight aggregate. In the process, additional drilling was done, providing a further look at the stratigraphy of the lake sediments as well as testing material for determining bloating capability and extent across a potential mine site. Based on both bench-scale preliminary testing and actual pilot-scale processing, the site studied can be classified as a significant potential economic resource.
Issues in the Widespread Adoption of Pit‐and‐Fissure Sealants (1982)

Seven issues affecting the use of sealants have been discussed, and five strategies have been suggested to promote their wider use in private and public settings. A strong initiative by industry, in conjunction with organized dentistry and government, is needed to generate public demand and to promote appropriate use by practitioners and auxiliaries. The most fruitful market for sealants at present and in the future may be through public health programs using dental auxiliaries, because the primary prevention of dental caries is stressed more in this area, whereas private practitioners tend to focus more on treating caries. During these times of financial restriction, there is all the more reason to focus effective caries prevention on those tooth surfaces that develop more than half of all carious lesions. The most efficient use of the limited private and public funds that are available to promote oral health must be made. Given the new sealant materials available and the opportunity to delegate their application to auxiliary personnel in both private and public practice, the challenge now is to promote the widespread use of this technology in conjunction with appropriate fluorides so that no child is denied the opportunity to enjoy a caries-free dentition.
Blind widely linear multiuser detection (2000)

Widely linear structures for multiuser detection of code division multiple-access signals are proposed, which jointly elaborate the received signal and its complex conjugate. Computer simulations show that the new structures significantly outperform the conventional linear ones, in terms of suppression capability of both wideband multiple-access and narrowband interference.
The role of proteolytic enzymes derived from crude bacterial collagenase in the liberation of hepatocytes from rat liver (1983)

Crude bacterial collagenase was chromatographed on DEAE-cellulose to yield three peaks with proteolytic activity: an arginine esterase (DEAE-1), gelatinase (DEAE-2) and a caseinolytic activity (DEAE-3). The arginine esterase and gelatinase activity fractions were slightly contaminated with each other but neither possessed caseinolytic activity; the caseinolytic fraction was devoid of arginine esterase and gelatinase activities. In addition, crude collagenase was fractionated by ZnII-affinity chromatography to produce a gelatinase peak (ZnII peak 1), which was free from arginine esterase and caseinolytic activities. The four fractions were compared to crude collagenase in their ability to liberate rat hepatocytes by using either liver slices or a standard perfusion technique. Compared to crude collagenase (0.05-0.1% w/v), which produced 70-80% liver digestion with approximately 80% cell viability, digestion with equivalent quantities of the isolated enzymic activities was relatively poor. Gelatinase activity (ZnII peak 1) was wholly ineffective and DEAE-1 and DEAE-2 each possessed only slight digestive properties. Hepatocyte liberation by the caseinolytic activity, DEAE-3, was partially successful (30-40% digestion, 25-30% viability) but only a portion of liver tissue was digested regardless of the quantity of DEAE-3 used. However, by mixing certain fractions before perfusion two gelatinase-dependent, cell-releasing mechanisms were identified: (a) DEAE-3 with ZnII peak 1 and (b) DEAE-1 mixed with either DEAE-2 or ZnII peak 1. Each system compared creditably with the digestive properties of an equivalent activity of crude collagenase. At present we are attempting to determine any differences between hepatocytes produced by the two enzymic mechanisms.