gebhart/patrepeval huggingface dataset:
Transparent Electrode Patterning using Laser Ablation for In-Plane Switching Liquid Crystal Display (2011)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Manoop Chenchiliyan, Sudheesh Palengara, Soney Varghese; Transparent Electrode Patterning using Laser Ablation for In‐Plane Switching Liquid Crystal Display. AIP Conf. Proc. 20 October 2011; 1391 (1): 294–296. https://doi.org/10.1063/1.3643528 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
A Raman spectroscopic study of arsenite and thioarsenite species in aqueous solution at 25 �C (2002)

The Raman spectra of thioarsenite and arsenite species in aqueous solution were obtained at room temperature. Solutions at constant ΣAs + ΣS of 0.1 and 0.5 mol kg-1 were prepared with various ΣS/ΣAs ratios (0.1–9.0) and pH values (~7–13.2). Our data suggest that the speciation of As under the conditions investigated is more complicated than previously thought. The Raman measurements offer evidence for at least six separate S-bearing As species whose principal bands are centered near 365, 385, 390, 400, 415 and 420 cm-1. The data suggest that at least two different species may give rise to bands at 385 cm-1, bringing the probable minimum number of species to seven. Several additional species are possible but could not be resolved definitively. In general, the relative proportions of these species are dependent on total As concentration, ΣS/ΣAs ratio and pH. At very low ΣS/ΣAs ratios we also observe Raman bands attributable to the dissociation products of H3AsO3(aq). Although we were unable to assign precise stoichiometries for the various thioarsenite species, we were able to map out general pH and ΣS/ΣAs conditions under which the various thioarsenite and arsenite species are predominant. This study provides a basis for more detailed Raman spectroscopic and other types of investigations of the nature of thioarsenite species.
Development of 10 kA class Nb/sub 3/Al superconducting cable by jelly-roll process (for fusion magnets) (1991)

A multifilamentary Cu/Nb/sub 3/Al composite strand was developed with a noncopper critical current density of more than 400 A/mm/sup 2/ at 12 T, by a jelly-roll process. A 10-kA cable-in-conduit conductor was fabricated to demonstrate its applicability to fusion magnets. The cable had 324 strands, and a circular CuNi seamless pipe was used as the conduit. The strand diameter was 0.88 mm and the filament diameter was 28 mu m. The heat treatment was performed at 820 degrees C for 2 h.
Adsorption, Mobility, and Microbial Degradation of Glyphosate in the Soil (1975)

Glyphosate [N-(phosphonomethyl)glycine] was readily bound to kaolinite, illite, and bentonite clay and to charcoal and muck but not to ethyl cellulose. Fe +++ and Al +++ -saturated clays and organic matter adsorbed more glyphosate than Na + or Ca + -saturated clays and organic matter. Glyphosate appears to be bound to the soil through the phosphonic acid moiety as phosphate in the soil competed with 14 C-glyphosate for adsorption sites. Glyphosate mobility in the soil was very limited and was affected by pH, phosphate level, and soil type. The 14 C-glyphosate was biodegraded in soil to 14 CO 2 possibly by co-metabolism. Potentiometric titrations of the compound gave pKa values of 2, 2.6, 5.6, and 10.6.
A 105-nW CMOS thermal sensor for power-aware applications (2011)

We propose an ultra-low power thermal sensor consisting of a nano-ampere CMOS current source circuit and a single bipolar transistor. Since the stability of current source circuits is the most important issue for our thermal sensor, we developed a circuit with an improved process and temperature stability. Our simulations and the measurements we conducted on the proposed thermal sensor demonstrated that it can be robustly operated in a wide temperature range. The power dissipation of the circuit was 105 nW for a 3-V power supply. The accuracy was within ±1°C in a wide temperature range of -20 to 120°C.
Foreword (2012)

Research Article| February 01, 2012 Foreword John M Sharp, Jr; John M Sharp, Jr Search for other works by this author on: GSW Google Scholar Barry J Hibbs Barry J Hibbs Search for other works by this author on: GSW Google Scholar Author and Article Information John M Sharp, Jr Barry J Hibbs Publisher: Association of Environmental & Engineering Geologists First Online: 02 Mar 2017 Online ISSN: 1558-9161 Print ISSN: 1078-7275 © 2012 Association of Environmental & Engineering Geologists Environmental & Engineering Geoscience (2012) 18 (1): 1. https://doi.org/10.2113/gseegeosci.18.1.1 Article history First Online: 02 Mar 2017 Cite View This Citation Add to Citation Manager Share Icon Share Facebook Twitter LinkedIn Email Permissions Search Site Citation John M Sharp, Barry J Hibbs; Foreword. Environmental & Engineering Geoscience 2012;; 18 (1): 1. doi: https://doi.org/10.2113/gseegeosci.18.1.1 Download citation file: Ris (Zotero) Refmanager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentBy SocietyEnvironmental & Engineering Geoscience Search Advanced Search The cover of a recent special issue (September 2011) of Scientific American on urban issues stated “We have seen the future and it is urban.” Geologists have commonly ventured to remote locales away from cultural complications to study the Earth, but perhaps understanding the geology where people live is equally or more important. The conversion of natural, agricultural, and other low-population density lands to urban or suburban land creates considerable changes in the hydrogeology of the area. As long ago noted by Sherlock (1922), mankind is a significant geological agent. The hydrogeological effects of urbanization were the subject of... You do not have access to this content, please speak to your institutional administrator if you feel you should have access.
Ageing‐associated tandem duplications in the D‐loop of mitochondrial DNA of human muscle (1994)

Using PCR techniques, we detected a approximately 260 bp (type I) and a approximately 200 bp (type II) tandem duplications in the mtDNA of muscle biopsies from aged individuals. Only one 70-year-old subject was found to harbour the type I and 28 out of 58 subjects had type II duplication. About 90% of the subjects harbouring the duplicated mtDNAs also had the 4,977 bp deletion. Moreover, the incidence and quantity of the type II duplication were found to increase with age. The proportion of the type II duplicated mtDNA in the muscle of a 71-year-old subject was 3.1% while that of a 55-year-old individual was only 0.78%. We suggest that the tandem duplications occur alone or with mtDNA deletions in human tissues in an age-dependent manner, and thereby cause synergistic deleterious effects on mitochondrial respiratory functions in human ageing.
Single-electron logic and memory devices (1999)

Single-electronics is believed to be the leading candidate for future digital electronics which will be able to operate at ~ 10 nm size scale and below. However, the problems of integrated single-electronics are quite serious whereby the future prospects are still uncertain. In this paper we discuss the operation principles and required parameters of several proposed families of single-electron logic, including the logic based on single-electron transistors, wireless single-electron logic and single-electron parametron. We also briefly discuss the single-electron memory which is easier to implement than logic and, hence, is more important from the practical point of view. As an example, we consider the background-charge-insensitive hybrid SET/FET memory.
HER2-specific aptide conjugated magneto-nanoclusters for potential breast cancer imaging and therapy (2013)

Here, we report a nanotheranostic system that enables simultaneous imaging and therapy of HER2-overexpressing tumors. We first screened an aptide-based phage library for HER2-specific peptide ligands, identifying a HER2-specific aptide (APT<sub>HER2</sub>) phage clone. Chemically synthesized APT<sub>HER2</sub> showed high affinity for its target protein (K<sub>d</sub>≈ 89 nM) and specifically bound HER2-overexpressing cells (NIH3T6.7) and tumor tissue slices. Next, we prepared HER2-specific-aptide-conjugated magneto-nanoclusters (APT<sub>HER2</sub>-MNCs) by a rehydration method using oleic acid-stabilized superparamagnetic iron oxide nanoparticles (SPIONs) and amphiphilic phospholipids, yielding nanoparticles with a hydrodynamic diameter of 47 ± 10 nm. The APT<sub>HER2</sub>-MNCs showed higher transverse (r<sub>2</sub>) relaxivity (∼180 mM<sup>-1</sup> s<sup>-1</sup>) and greater drug-loading capacity compared to the equivalent isolated SPIONs (∼120 mM<sup>-1</sup> s<sup>-1</sup>). When intravenously injected into HER2-overexpressing NIH3T6.7 tumor-bearing mice, APT<sub>HER2</sub>-MNCs substantially accumulated in tumor tissue, enhancing the relative signal by ∼45% at 3 h post-injection. This allowed us to detect the tumor using magnetic resonance imaging. Furthermore, after docetaxel loading, the drug-loaded APT<sub>HER2</sub>-MNCs remarkably inhibited the growth of HER2-overexpressing tumors (∼50% relative to controls) with little apparent toxicity, measured as changes in body weight. Together, these results indicate that APT<sub>HER2</sub>-MNCs show promise as an efficient nanotheranostic system that enables specific cancer imaging as well as targeted therapy.
Effects of Electronic Fetal-Heart-Rate Monitoring, as Compared with Periodic Auscultation, on the Neurologic Development of Premature Infants (1990)

In a multicenter, randomized clinical trial, we assessed the early neurologic development of 93 children born prematurely whose heart rates were monitored electronically during delivery and compared it with that of 96 children born prematurely whose heart rates were periodically monitored by auscultation. All the children were singletons with cephalic presentation, and all weighed less than or equal to 1750 g at birth. The mental and psychomotor indexes of the Bayley Scales of Infant Development (standardized mean score +/- SD, 100 +/- 16) and a formal neurologic examination were administered at three follow-up visits (at 4, 8, and 18 months of age, corrected for gestational age). At 18 months, the mean mental-development scores in the groups receiving electronic fetal monitoring and periodic auscultation were 100.5 +/- 2.4 and 104.9 +/- 1.8, respectively (P greater than 0.1). The mean psychomotor-development scores in the two groups at 18 months were 94.0 +/- 2.4 and 98.3 +/- 1.8, respectively (P greater than 0.1). The incidence of cerebral palsy was higher in the electronically monitored group--20 percent as compared with 8 percent in the group that was monitored by auscultation (P less than 0.03). In the electronic-fetal-monitoring group (but not in the periodic-auscultation group), the risk of cerebral palsy increased with the duration of abnormal fetal-heart-rate patterns, as assessed by retrospective review (chi 2 trend = 12.71, P less than 0.001). The median time to delivery after the diagnosis of abnormal fetal-heart-rate patterns was 104 minutes with electronic fetal monitoring, as compared with 60 minutes with periodic auscultation. We conclude that as compared with a structured program of periodic auscultation, electronic fetal monitoring does not result in improved neurologic development in children born prematurely.
A case-based reasoning system for subjective assessment (1986)

5-Hydroxymethyl-2'-deoxyuridine (HmdUrd), a cytotoxic analogue of thymidine, has been proposed for use as an anticancer agent. HmdUrd is incorporated into DNA and then removed at a rate of 30-40% per day. The removal of HmdUrd from DNA has been attributed to the action of 5-hydroxymethyluracil-DNA glycosylase (HmUra-DNA glycosylase). We demonstrated the release of [3H]HmUra into the growth medium of V79 Chinese hamster cells that had incorporated [3H]HmdUrd into their DNA. The amount of [3H]HmUra recovered from the growth medium was equal to the amount of [3H]HmdUrd lost from DNA. These experiments confirmed that the initial step of repair of HmUra in DNA was mediated by DNA glycosylase activity. A combination of HmUra and HmdUrd resulted in increased uptake of HmdUrd by cells and increased cytotoxicity. The increased incorporation of HmdUrd into DNA was not due to inhibition of repair. 3-Aminobenzamide, an inhibitor of poly(ADP-ribose) synthesis, was cytotoxic to cells which incorporated and repaired HmdUrd. The extent of toxicity was directly related to the number of HmUra residues in DNA. HeLa cells, known to be resistant to the toxic effects of HmdUrd, do not incorporate HmdUrd into their DNA. HeLa cells were resistant to the toxic effects of 3-aminobenzamide, confirming that the absence of HmdUrd in their DNA was not due to an accelerated rate of repair. These experiments indicate that the potential therapeutic antineoplastic properties of HmdUrd may be enhanced by using HmUra to increase the incorporation of HmdUrd into DNA and 3-aminobenzamide to interfere with repair of HmUra in DNA.
Detection and mitigation of spam in IP telephony networks using signaling protocol analysis (2006)

We propose an innovative method to detect and block spam (unsolicited bulk calls) in IP telephony networks. Rapid adoption of voice over IP (VoIP) technology introduces new powerful options for spammers and telemarketers to increase their productivity and effectiveness. To date a few concepts have already been proposed in the VoIP spam prevention area. These prior solutions focus mainly on identity control and reliable authentication and follow in this regard the email spam solutions approach. Such measures imply at least strong collaboration of service providers and universal standardization. In this paper we describe a new method based on the analysis of the VoIP signaling messages which can assist service providers in detecting spam activity targeting their customers. This "locally centric" approach would enable a service provider to handle the call before the actual voice spam content reaches the recipient. The detection parameters depend solely on the local service provider's policy; no end-users participation/compliance is required
The Ah Locus: Genetic Differences in Toxicity, Cancer, Mutation, and Birth Defects (1989)

(1989). The Ah Locus: Genetic Differences in Toxicity, Cancer, Mutation, and Birth Defects. Critical Reviews in Toxicology: Vol. 20, No. 3, pp. 153-174.
Laboratory evaluation of AI3-37220, AI3-35765, CIC-4, and deet repellents against three species of mosquitoes. (1999)

Four repellents, N,N-diethyl-3-methyl-benzamide (deet), 2-hydroxy-methyl-cyclohexyl acetic acid lactone (CIC-4), and 2 piperidines (1-[3-cyclohexen-1-ylcarbonyl] piperidine [AI3-35765] and 1-[3-cyclohexen-1-ylcarbonyl]-2-methylpiperidine [AI3-37220]) were evaluated alone and in combination against Aedes aegypti, Anopheles stephensi, and Culex quinquefasciatus using a modified in vitro test system. This method was a valuable tool for comparing effective concentrations of the new compounds. Because of the controlled conditions of the test, it was possible to use the results of assays that had been conducted over a 5-year period and to perform the many replications necessary to evaluate combinations of compounds. The new candidate repellents were generally as effective as deet. Although speculative at this time, there was some evidence of synergistic interaction. Repellent combinations of CIC-4/AI3-37220/AI3-35767, deet/AI3-35765, and deet/AI3-37220/AI3-35765 against An. stephensi and CIC-4/AI3-35765, deet/AI3-37220/AI3-35765, AI3-37220/AI3-35765, and CIC-4/AI3-37220 against Ae. aegypti were more effective than the component compounds alone.
Thermal instability of germacrone: implications for gas chromatographic analysis of thermally unstable analytes (1989)

The rearrangement of germacrone (1) to β-elemenone (2) is common during gas chromatographic (GC) analysis, with the conversion taking place in the injector port at temperatures above 250 °C as well as on the column. While production of 2 in the injector is evident from the gas chromatographic trace, 2 produced from 1 during its migration down the column is difficult to detect because of the diffuse nature of the chromatographic peak produced by this process. A mathematical model and kinetic parameters (A = (1.35 ± 0.03) × 10 −3 s −1 ; E a = 137 ± 4 kJ mol −1 ) determined from the reaction in solution can be used to estimate the degree of conversion of 1 to 2 for chromatographic runs (including temperature-programmed analyses). The results of these calculations verify that substantial amounts of 1 are converted to 2 under conditions that are commonly used for the analysis. The method for modeling thermally induced rearrangements in nonisothermal processes represents the first approach to quantitatively assessing their importance in GC analyses of thermally labile substances. Keywords: kinetics, gas chromatography, thermal rearrangement, germacrone, β-elemenone.
A monoclonal antibody directed against the high-affinity lysine-binding site (LBS) of human plasminogen. Role of LBS in the regulation of fibrinolysis (1986)

One of thirty murine monoclonal antibodies, raised by immunization with human plasmin-alpha 2-antiplasmin complex, was found to be directed against the high-affinity lysine-binding site in plasminogen. Indeed, this antibody (MA-HAL) reacted with plasminogen and with a fragment of plasminogen composed of the first three triple-loop structures (LBS I) and was displaced by 6-aminohexanoic acid (50% displacement at 25 microM). In competitive radioimmunoassays the binding of radiolabeled plasminogen to MA-HAL was reduced to 50% with 2.3 microM alpha 2-antiplasmin or 1.3 microM histidine-rich glycoprotein, which corresponds to the known dissociation constants between these ligands and the high-affinity lysine-binding site of plasminogen. MA-HAL did not influence the activation of plasminogen by tissue-type plasminogen activator in the absence of CNBr-digested fibrinogen, but abolished the effect of CNBr-digested fibrinogen on the Michaelis constant of the reaction. MA-HAL reduced the reaction rate between plasmin and alpha 2-antiplasmin by a factor 20 and abolished the binding of plasminogen to fibrin. These results indicate that MA-HAL specifically binds to and masks the high-affinity lysine-binding site of plasminogen. It therefore is a useful tool for the investigation of the role of this structure in the regulation of fibrinolysis, both at the level of fibrin-stimulated activation of plasminogen and of the inhibition of generated plasmin.
Low power 8T SRAM using 32nm independent gate FinFET technology (2008)

In this paper, new SRAM cell design methods for FinFET technology are proposed. One of the most important features of FinFET is that the independent front and back gate can be biased differently to control the current and the device threshold voltage. By controlling the back gate of FinFET, SRAM cell can be designed for minimum power consumption. This paper proposes a new 8T (8 transistors) SRAM structure that reduces dynamic power in writing operation and provides wider SNM (Static Noise Margin). Using the new FinFET based 8T SRAM cell, dynamic power consumption is reduced about 48% and the SNM is widened up to 56% compared to the conventional 6T SRAM at the expense of 2% leakage power and 3% write delay increase.
TLR Triggering on Tolerogenic Dendritic Cells Results in TLR2 Up-Regulation and a Reduced Proinflammatory Immune Program (2009)

Tolerogenic dendritic cells (TDC) offer a promising therapeutic potential to ameliorate autoimmune diseases. Reported to inhibit adaptive immune responses, little is known about their innate immunity receptor repertoire. In this study, we compared three types of human TDC (IL-10-DC, dexamethasone (DX)-DC, and 1,25(OH)(2)D(3)-DC) by their TLR expression and response to a set of TLR ligands. TDC are endowed with the same TLR set as standard monocyte-derived dendritic cells but respond differentially to the TLR stimuli Pam3CSK4, polyinosinic-polycytidylic acid, LPS, and flagellin. TDC expressed low or no IL-12-related cytokines and remarkably elevated IL-10 levels. Interestingly, only TDC up-regulated the expression of TLR2 upon stimulation. This boosted the tolerogenic potential of these cells, because IL-10 production was up-regulated in TLR2-stimulated, LPS-primed DX-DC, whereas IL-12 and TNF-alpha secretion remained low. When comparing the TDC subsets, DX-DC and 1,25(OH)(2)D(3)-DC up-regulated TLR2 irrespective of the TLR triggered, whereas in IL-10-DC this effect was only mediated by LPS. Likewise, DX-DC and 1,25(OH)(2)D(3)-DC exhibited impaired ability to mature, reduced allostimulatory properties, and hampered capacity to induce Th1 differentiation. Therefore, both DX-DC and 1,25(OH)(2)D(3)-DC display the strongest tolerogenic and anti-inflammatory features and might be most suitable tools for the treatment of autoimmune diseases.
Cholestyramine Therapy for Dyslipidemia in Non–Insulin-dependent Diabetes Mellitus: A Short-Term, Double-Blind, Crossover Trial (1994)

In carefully selected male patients with NIDDM and high LDL cholesterol and normal triglyceride levels, cholestyramine therapy effectively reduces LDL levels and also may improve glycemic control. The long-term efficacy of cholestyramine therapy in patients with NIDDM needs further evaluation.
Retinoid X receptor activation is essential for docosahexaenoic acid protection of retina photoreceptors (2013)

We have established that docosahexaenoic acid (DHA), the major polyunsaturated fatty acid in the retina, promotes survival of rat retina photoreceptors during early development in vitro and upon oxidative stress by activating the ERK/MAPK signaling pathway. Here we have investigated whether DHA turns on this pathway through activation of retinoid X receptors (RXRs) or by inducing tyrosine kinase (Trk) receptor activation. We also evaluated whether DHA release from phospholipids was required for its protective effect. Addition of RXR antagonists (HX531, PA452) to rat retinal neuronal cultures inhibited DHA protection during early development in vitro and upon oxidative stress induced with Paraquat or H2O2. In contrast, the Trk inhibitor K252a did not affect DHA prevention of photoreceptor apoptosis. These results imply that activation of RXRs was required for DHA protection whereas Trk receptors were not involved in this protection. Pretreatment with 4-bromoenol lactone, a phospholipase A2 inhibitor, blocked DHA prevention of oxidative stress-induced apoptosis of photoreceptors. It is noteworthy that RXR agonists (HX630, PA024) also rescued photoreceptors from H2O2-induced apoptosis. These results provide the first evidence that activation of RXRs prevents photoreceptor apoptosis and suggest that DHA is first released from phospholipids and then activates RXRs to promote the survival of photoreceptors.
Antineoplastic Agents. 604. The Path of Quinstatin Derivatives to Antibody Drug Conjugates (2017)

To further evaluate the exceptional cancer cell growth inhibition by the quinstatins, of which one of the series, quinstatin 8, approaches the exceptional cytotoxic activity of the parent dolastatin 10 (1), four of the quinstatins have been converted to desmethyl derivatives. Three of the four (4, 5, and 8 [7b-d]) were next bonded to the linker (8) employed in the synthesis of the very successful and structurally related anticancer drug Adcetris (3). Owing to these structural modifications, a next step could be taken by bonding to a monoclonal antibody, thereby producing an antibody drug conjugate (ADC) related to Adcetris structurally but with the possibility of a wider spectrum of activity and utility.