gebhart/patrepeval huggingface dataset:
Phase II trial of paclitaxel in patients with progressive ovarian carcinoma after platinum-based chemotherapy: a Gynecologic Oncology Group study. (1994)

Taxol is a highly active agent in ovarian carcinoma, even in patients who are clinically resistant to platinum-based chemotherapy, and produces frequent and severe, albeit manageable, myelosuppression. It is clearly active as salvage therapy for ovarian carcinoma.
Characteristics of Olfactory Disorders in Relation to Major Causes of Olfactory Loss (2002)

Among many complaints of olfactory loss, the predominant ones were food related. This loss in QoL seemed to be of greater importance in younger than in older people, and women seem to be affected more strongly than men.
Notes - Basic Zinc Double Salts of O,O-Diakyl Phosphorodithioic Acids (1956)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNotes - Basic Zinc Double Salts of O,O-Diakyl Phosphorodithioic AcidsV. Wystrach, E. Hook, and G. L. ChristpoherCite this: J. Org. Chem. 1956, 21, 6, 705–707Publication Date (Print):June 1, 1956Publication History Published online4 March 2003Published inissue 1 June 1956https://pubs.acs.org/doi/10.1021/jo01112a616https://doi.org/10.1021/jo01112a616research-articleACS PublicationsRequest reuse permissionsArticle Views366Altmetric-Citations67LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
TRANS-SUPPRESSION OF GENE EXPRESSION BY HEPATITIS C VIRAL CORE PROTEIN (1994)

We have demonstrated that the truncated hepatitis C (HCV) core protein with its C-terminal hydrophobic domains deleted is translocated to the nucleus of transfected cells (22). In this study, intact and truncated core proteins of HCV were transiently expressed in a human hepatoblastoma cell line, HepG2, and their effects on the expression of the chloramphenycol acethyl transferase (CAT) gene driven by viral and cellular promoters were examined. The intact core protein of 22 kDa which is localized in the cytoplasm of the transfected cells suppressed the expression in all of the promoters tested. They were promoters of the SV40 early region, the c-fos oncogene, the retinoblastoma susceptibility gene, the beta-interferon gene and the beta-actin gene. In contrast, the truncated HCV core protein located in the nucleus did not show such a suppressive activity. The HCV core protein appears to function not only as a viral structural protein but as a regulator of gene expression and it might act as a suppressive factor for the cellular gene expression.
Blind Faith Gas Export Pipeline Pre-commissioning and Commissioning (PCC) Challenges (2010)

Abstract This paper concentrates on the challenges, experience and lessons learned during the Precommissioning and Commissioning (PCC) of the Blind Faith 14?? to 18?? gas export pipeline. The PCC for the Blind Faith gas pipeline took place in 2008 and was an extremely challenging phase of the project. The challenges were associated with the complexity of the subsea architecture at the interconnection of the new Blind Faith gas pipeline and the existing Canyon Chief gas pipeline (Refer to OTC paper 19764 for the tie-in between Blind Faith and Canyon Chief systems). The complexity was further challenged by the need to minimize the amount of shut in days for the production of the Canyon Chief gas pipeline. The PCC occurred in two phases: Phase I - Without shutting in existing production on Canyon Chief gas pipeline:Hydrotest the Blind Faith gas pipelineDewater and inhibit the Blind Faith gas pipeline subsea by a pig train consisting of 4 pigs and three slugs of MeOH Phase II - Shutting in existing production on Canyon Chief gas pipeline:Blowdown the Canyon Chief gas pipeline (during blowdown, recover the gas rather than venting to atmosphere)Dewater and inhibit an isolated two miles section in the Canyon Chief gas pipeline by the pig train from Blind FaithRetrieve pigs and recover methanol at MP-261ARestart Canyon Chief pipeline and provide buyback gas to Blind Faith The PCC architecture and commissioning challenges included the following:Deepwater GoM - up to 6800' fswMultiple pipeline diametersLong pipeline distanceLimited nitrogen flow rateDewatering through a gas pipelineDrying of gas pipelineLimiting number of shutdown days for existing production The PCC effort took approximately three months to complete, during which time the project experienced two back to back hurricanes and Phase I was performed twice due to pig related issues.
Automatic access controls in the Defense Message System (DMS) (2003)

Access controls in legacy messaging systems such as AUTODIN rely heavily on human intervention. DMS provides an organizational and individual messaging capability with automatic access control based on a message security label and the authorizations of the originator and recipient as conveyed in their respective International Standards Organization (ISO) X.509 Certificates and Extensions. This paper presents an overview of the way this automatic access control process is performed, the features of the process, and the resources required for execution. Concepts discussed include types of access control means of conveying sensitivities and authorization, security policies, certificate policies, and the process for verifying authorizations, among others.
The Development of Multiple Talents: Conceptualization and Empirical Studies (2002)

A 4-year joint research project(1999-2003), entitled The Development of Multiple Talents(DMT), has been designed and carrying out under the sponsorship of the National Science Council, R.O.C. (Taiwan). A 3-dimension construct is proposed for the DMT: form of talents (10 forms, mainly based on Gardner's theory of multiple intelligences), function of talents (3 functions, based on Sternberg's conception of successfulintelligence), and developmental stage (4 stages, from pre-school to senior high). To take an example of its empirical studies, Wu and Chien (2000), based on a renovated conception of personal intelligence, developed the Personal Intelligence Inventory (PII). By means of the PII, it was found that there were some personal intelligence differences between gifted and regular pupils; however, gifted group was not as superior as on academic performance to the regular one (Wu & Chien, 2000). It was also found that there were significant relationships between pupils' personal intelligence and school adjustment in both groups (Tsai & Wu, 2000).
QoS based approach for LTE-WiFi handover (2016)

Nowadays, the current trend is to integrate WiFi with Long Term Evolution (LTE) networks in order to meet the growing demand for huge amounts of data traffic and provide ubiquitous coverage. Seamless mobility between heterogeneous networks with the required Quality of Services (QoS) provisioning for Mobile Terminals (MTs) is one of the most challenging issues while considering LTE-WiFi integration. Several studies reported in the literature have addressed the vertical handover (VHO) challenges between the two access networks. However, none of these approaches provides the MTs with the required QoS without adding a new entity or increasing the signaling cost. Thus, this paper proposes a VHO decision algorithm between LTE-WiFi heterogeneous networks. A performance study is conducted which compares the proposed approach with the WiFi First (WF) approach. Results show that the proposed approach can support QoS and reduce Wi-Fi blocking probability without adding any new entities to the infrastructure or increasing signaling costs. Also, the proposed approach outperforms existing solutions in terms of delay and signaling costs, while providing the MTs with the required QoS.
Recent studies on the immunomodulatory effects of CD244 (2012)

The immunoreceptor CD244 belongs to the family of signal lymphocyte activation molecules.CD244 plays important roles in regulating the activity of NK cells,T cells and eosinophils.CD244 is also very important in infection,inflammation and tumor immunity.Therefore,study on CD244 would have a significant influence on the immunotherapy for infections diseases and tumor.

Key words: 
CD244; Immunomodulatory mechanisms; Infection; Tumor
Enhanced Electron Injection Efficiency and Electroluminescence in Organic Light-Emitting Diodes by Using an Sn/Al Cathode (2002)

A series of organic light-emitting diodes (OLEDs) have been fabricated with different thicknesses of the tin (Sn) layer. The structure of the devices is indium-tin oxide (ITO)/copper phthalocyanine (CuPc) (12nm)/N, N′-diphenyl-N, N′-bis(1-naphthyl)-(1,1′biphenyl)-4, 4′-diamine (NPB) (60nm)/tris-(8-hydroxyquinoline)aluminum (Alq3) (60nm)/Sn/aluminium (Al (120nm). It is found that compared to OLEDs with only an Al cathode, both the electron injection efficiency and electroluminescence are improved when the thickness of the Sn layer is properly chosen. The maximum efficiency and brightness of the devices with Sn (2.1 nm) Al and Al cathode are 0.54 lm/W and 9800cd/m2, and 0.26 lm/W and 3000cd/m2, respectively. One possible explanation to this phenomenon is that the enhancement of the electron density of the Sn layer due to the electron transfer from the Al to the Sn layer leads to the improvement of the electron injection efficiency and electroluminescence.
<i>Yersinia enterocolitica</i>Induces Apoptosis and Inhibits Surface Molecule Expression and Cytokine Production in Murine Dendritic Cells (2004)

ABSTRACT Yersinia enterocolitica evades innate immunity by expression of a variety of pathogenicity factors. Therefore, adaptive immunity including CD4 + T cells plays an important role in defense against Y. enterocolitica . We investigated whether Y. enterocolitica might target dendritic cells (DC) involved in adaptive T-cell responses. For this purpose, murine DC were infected with Y. enterocolitica wild-type and mutant strains prior to incubation with ovalbumin (OVA) as antigen and 5-(6)-carboxyfluorescein diacetate N -succinimidyl ester-labeled OVA-specific T cells from DO11.10 mice. While T-cell proliferation was partially affected by infection of DC with plasmid-cured and YopP-deficient Yersinia mutant strains, no T-cell proliferation occurred after infection of DC with wild-type Y. enterocolitica . Infection of DC with Y. enterocolitica wild type resulted in decreased up-regulation of major histocompatibility complex class II, CD54 (intercellular adhesion molecule 1), CD 80, and CD86 expression. Experiments with plasmid-cured Y. enterocolitica or a YopP-deficient mutant strain revealed that YopP accounts for inhibition of surface molecule expression. Wild-type Y. enterocolitica suppressed the release of KC, tumor necrosis factor alpha, interleukin-10 (IL-10), and IL-12 by DC, while infection of DC with plasmid-cured Y. enterocolitica or with the YopP-deficient mutant resulted in the production of these cytokines. Moreover, infection with wild-type Y. enterocolitica induced apoptosis in DC mediated by YopP. Apoptosis occurred despite translocation of NF-κB to the nucleus, as demonstrated by electromobility shift assays. Together, these data demonstrate that Y. enterocolitica targets functions of murine DC that are required for T-cell activation. This might contribute to evasion of adaptive immune responses by Y. enterocolitica .
A/B Testing: The Most Powerful Way to Turn Clicks Into Customers (2013)

A guide to delivering a better user experience through A/B testingA/B Testing outlines a simple way to test several different versions of a web page with live traffic, and then measure the effect each version has on visitors. Using A/B testing you can determine the most effective way to increase conversion ratethe rate at which visitors convert into customers. The average conversion rate across the web is only 2%. That means 98% of visitors to most websites don't end up converting. Using A/B testing, companies can improve the effectiveness of their marketing and user experience and in doing so can sometimes double or triple their conversion rates.In the past, marketing teams were dependent on IT and engineering to implement A/B tests, and that proved to be a costly bottleneck. Today, the market for A/B testing is growing very fast, in no small part due to this transition from IT to marketing. Offers best practices and lessons learned from over 100,000 experiments run by over 2,000 Optimizely customersDetails a roadmap for how to use A/B testing to personalize your customer's web experience and a practical guide to start A/B testing todayAuthors Dan Siroker and Pete Koomen are cofounders of Optimizely.com, an user-friendly testing system that more than 2,000 organizations use Marketers and web professionals will become obsolete if they don't embrace a data-driven approach to decision making. This book shows you how, no matter your technical expertise.
Anti-neutrophil antibodies in inflammatory bowel disease: prevalence and diagnostic role. (1992)

Anti-neutrophil antibodies have been shown in sera from patients with a variety of inflammatory diseases. Those reacting with components of neutrophil cytoplasm are associated with systemic vasculitis. Both nuclear and perinuclear staining patterns on human neutrophils have been reported using sera from patients with inflammatory bowel disease. We have evaluated the reactivity against human neutrophils of sera from 100 patients with inflammatory bowel disease, 14 disease controls, and 20 normal volunteers. Altogether 27/50 (54%) sera from patients with ulcerative colitis contained antibodies that reacted with cytospun ethanol fixed neutrophils compared with 5/50 (10%) from Crohn's disease (p less than 0.001) and 0/34 control sera (p less than 0.001). All seven sera from patients with proctitis alone were negative (p less than 0.01). There was no correlation between presence or titre of anti-neutrophil antibodies and either disease activity or treatment. Positive sera gave three different staining patterns on human neutrophils. The predominant pattern was perinuclear (17/32); 12 sera gave a cytoplasmic and three a homogeneous nuclear staining pattern. None of the patients or the controls had antibodies to myeloperoxidase, elastase, or serine proteinase 3, all of which are recognised by anti-neutrophil cytoplasmic antibodies. Only 2/27 sera positive by indirect immunofluorescence reacted with an extract of neutrophil primary granules. In conclusion, anti-neutrophil antibodies occur more commonly in ulcerative colitis than in Crohn's disease or control subjects and the anti-neutrophil antibodies found in inflammatory bowel disease are different from those associated with vasculitis.
Fl-160. A surface antigen of Trypanosoma cruzi that mimics mammalian nervous tissue. (1989)

Chagas' disease, caused by Trypanosoma cruzi, is an excellent model for autoimmune disease induced by an infectious agent. Transfer of T cells, directed against crossreactive antigens of T. cruzi and nervous tissue, have been shown to reproduce pathology found in chronic Chagas' disease. We used recombinant DNA technology to characterize one of these crossreactive antigens (Fl-160). We have cloned DNA from T. cruzi, which expresses a protein corresponding to a 160-kD protein found on the surface of the trypanosome, overlying the flagellum. This clone hybridizes to a 4.5-kb poly(A)+ RNA that is distributed in a differentiation-specific manner, suggesting expression of this protein is transcriptionally controlled. Antibodies to this protein crossreact with a 48-kD mammalian nervous tissue protein found in sciatic nerve, brain, and myenteric plexi of gut. The myenteric plexi are destroyed by inflammatory infiltrates in Chagas' disease, leading to the characteristic megaesophagus and megacolon Chagas' disease pathology. Thus, this antigen is a candidate antigen for autoimmune mimicry leading to nervous tissue pathology.
Production, Purification and Partial Characterization of 1,4-beta-Glucosidase Enzymes from Sporotrichum pulverulentum (1978)

The production of 1,4-β-glucosidase activity by the rot fungus Sporotrichum pulverulentum has been investigated. It was found that cellobiose or cellulose is necessary to cause induction. With cellobiose as sole carbon source only cell-wall-bound enzymes are produced. For extracellular excretion cellulose seems to be a necessary carbon source. The purification procedures, for purification of enzyme activity in the culture solution, involve the following steps: (a) ultrafiltration, (NH4)2SO4 precipitation and dialyses; (b) preparative slab gel isoelectric focusing I, pH range 3–10; (c) phenyl-Sepharose chromatography; (d) preparative slab gel isoelectric focusing II, pH range 3–5. On the phenyl-Sepharose column the β-glucosidase activity was associated with two separable enzyme peaks, enzyme A and B. When these enzymes were subjected to further purification on preparative isoelectric focusing II, enzyme A was split into two peaks, A1 and A2, and enzyme B was split into three peaks, B1, B2 and B3. The significance of the separations is discussed. The isoelectric points of all the enzymes have been determined and found to vary between 4.52 to 5.15. The molecular weights, determined by dodecylsulphate-polyacrylamide gel electrophoresis, vary between 165000 and 182000. The kinetic constants Km and Ki have been determined for enzyme A and B as well as for the cell-bound β-glucosidase activity. Km for cellobiose was for both enzyme A and B higher than Km for p-nitrophenyl β-d-glucoside. Km/Ki of the free enzymes for gluconolactone is approximately 2500 (enzyme B) to 13000 (enzyme A) with cellobiose as substrate.
Evaluation of islets derived from human fetal pancreatic progenitor cells in diabetes treatment (2013)

Human fetal pancreatic progenitor cells have good capacity for generating insulin producing cells and provide a promising potential source for diabetes treatment.
Nitrogen-Doped Porous Carbons As Electrode Materials for High-Performance Supercapacitor and Dye-Sensitized Solar Cell (2015)

Activated N-doped porous carbons (a-NCs) were synthesized by pyrolysis and alkali activation of graphene incorporated melamine formaldehyde resin (MF). The moderate N doping levels, mesopores rich porous texture, and incorporation of graphene enable the applications of a-NCs in surface and conductivity dependent electrode materials for supercapacitor and dye-sensitized solar cell (DSSC). Under optimal activation temperature of 700 °C, the afforded sample, labeled as a-NC700, possesses a specific surface area of 1302 m2 g(-1), a N fraction of 4.5%, and a modest graphitization. When used as a supercapacitor electrode, a-NC700 offers a high specific capacitance of 296 F g(-1) at a current density of 1 A g(-1), an acceptable rate capability, and a high cycling stability in 1 M H2SO4 electrolyte. As a result, a-NC700 supercapacitor delivers energy densities of 5.0-3.5 Wh kg(-1) under power densities of 83-1609 W kg(-1). Moreover, a-NC700 also demonstrates high electrocatalytic activity for I3- reduction. When employed as a counter electrode (CE) of DSSC, a power conversion efficiency (PCE) of 6.9% is achieved, which is comparable to that of the Pt CE based counterpart (7.1%). The excellent capacitive and photovoltaic performances highlight the potential of a-NCs in sustainable energy devices.
Phosphorylation of specific sets of tau isoforms reflects different neurofibrillary degeneration processes (1998)

Tau proteins are the basic components of filaments that accumulate within neurons during neurofibrillary degeneration, a degenerating process with disease-specific phenotypes. This specificity is likely to be sustained by both phosphorylation state and isoform content of tau aggregates that form neuronal inclusions. In the present study, characterization of tau isoforms involved in neurofibrillary degeneration in Alzheimer's disease, Pick's disease, corticobasal degeneration and progressive supranuclear palsy was performed. Both analyses by immunoblotting using specific tau antibodies and cell transfection by tau isoform cDNAs allowed us to demonstrate the aggregation of (1) the six hyperphosphorylated tau isoforms in Alzheimer's disease, (2) tau isoforms without exon 10-encoding sequence in Pick's disease and (3) hyperphosphorylated exon 10-tau isoforms in corticobasal degeneration and progressive supranuclear palsy. Thus, neurofibrillary degeneration phenotypes are likely to be related to the phosphorylation of different combinations of tau isoforms (with and/or without exon 10-encoding sequence) in subpopulations of neurons.
From Knowing-About To Knowing-To: Development Of Engineering Pedagogical Content Knowledge By Elementary Teachers Through Perceived Learning And Implementing Difficulties (2014)

The present study sought to reveal how elementary teachers develop their engineering pedagogical content knowledge (PCK) after leaving professional development programs to practice engineering teaching in real classroom settings. Participants of this study were the elementary teachers who received one-week training of engineering education provided by EfF (a P-12 Engineering teaching and learning institute in a Midwestern university). Data of this study were collected from these elementary teachers through face-to-face interviews and an online open-ended survey. Based on a phenomenological research method and a constructivist ELC (engineering instruction, learners, and contexts) framework developed by the researchers to investigate engineering PCK development, this study explored the elementary teachers’ lived engineering teaching experiences following the procedures of inductive qualitative data analysis. Findings yielded in this study revealed that the elementary teachers developed their knowledge about engineering teaching and learning situations through their engineering teaching practice. But such knowledge was the knowledge of knowing-about and it did not automatically transfer into the elementary teachers’ engineering PCK or knowing-to knowledge allowing them to act effectively and responsively to engineering teaching and learning situations at hand. In their engineering teaching practice, the elementary teachers engaged themselves in a dynamic and evolving trial-failure-success process. It was in this process that the elementary teachers made sense of new engineering teaching and learning situations and transformed their knowing-about into engineering PCK responsive to these situations.