gebhart/patrepeval huggingface dataset:
Thermal and Optical Characterization of Silicon-Based Tunable Optical Thin-Film Filters (2007)

In this paper, we report on the successful fabrication and comprehensive optical and electrothermal characterization of a silicon-based tunable optical filter. Of particular interest here are the static and transient electrothermal characteristics of the filter membrane. The filter is configured as a Fabry-Perot resonator with dielectric Bragg reflectors and is fabricated as a stress-compensated multilayer of dielectric thin-films. Tunability is achieved by changing the refractive index of the solid-state cavity material through thermal modulation, accomplished by Joule heating in metal thin-film resistors. The filter layers are configured as a membrane to provide good thermal isolation and its electrothermal behavior was characterized in steady-state and dynamically. A maximum stable temperature difference of 450 K and a heating efficiency of 13.4 K mW <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> were measured with a thermal time constant for the filter hotplate of 3 ms. The filter's spectral width is 0.28 nm at a wavelength of 1550 nm and through thermal modulation it was possible to shift the filter peak over more than 29 nm.
Identification of Highly Conserved and Broadly Cross-Reactive HIV Type 1 Cytotoxic T Lymphocyte Epitopes as Candidate Immunogens for Inclusion in <i>Mycobacterium bovis</i> BCG-Vectored HIV Vaccines (2000)

One of the fundamental goals of current strategies to develop an efficacious vaccine for AIDS is the elicitation of cytotoxic T lymphocyte (CTL) reactivities capable of recognizing cells infected with different subtypes of the human immunodeficiency virus type 1 (HIV-1). In efforts to explore new vaccine candidates by the UNAIDS/WHO Vaccine Committee, we review the most recent data concerning CTL epitopes that are conserved among the different HIV-1 subtypes. Moreover, we examine HLA allelic frequencies in several different populations, to determine those that could contribute to the goal of a cumulative phenotype frequency (CP) of at least 80%. By analyzing conserved epitopes in the context of HLA restricting alleles, we define a set of HIV-1 gene regions that may have the greatest potential to induce cross-clade reactive CTLs. The absence of well-defined correlates of immune protection that link CTL epitopes to delayed disease progression and/or prevention of infection does not permit an assignment of rank order of the most relevant component of a candidate vaccine. Thus far, most of the studies conducted in clade B-infected patients to define conserved and immunodominant epitopes indicate gag and pol gene products to be the most conserved among the HIV-1 subtypes. Moreover, anti-Pol and -Gag CTL responses appear to correlate inversely with disease progression, suggesting that they should be among the first choice of antigens to be included in a candidate vaccine construct aimed at induction of broad CTL responses. The impact of a clade B-based vaccine as a worldwide candidate capable of inducing protective immune responses can be determined only after "in vivo" studies. Meanwhile, extensive parallel studies in populations infected with non-clade B HIV-1 subtypes should define the patterns of immunodominant epitopes and HLA for comparison with the data already collected in clade B-infected subjects.
Social Influence-Based Group Representation Learning for Group Recommendation (2019)

As social animals, attending group activities is an indispensable part in people's daily social life, and it is an important task for recommender systems to suggest satisfying activities to a group of users. The major challenge in this task is how to aggregate personal preferences of group members to infer the decision of a group. Conventional group recommendation methods applied a predefined strategy for preference aggregation. However, these static strategies are too simple to model the real and complex process of group decision-making, especially for occasional groups which are formed ad-hoc. Moreover, group members should have non-uniform influences or weights in a group, and the weight of a user can be varied in different groups. Therefore, an ideal group recommender system should be able to accurately learn not only users' personal preferences but also the preference aggregation strategy from data. In this paper, we propose a novel group recommender system, namely SIGR (short for "Social Influence-based Group Recommender"), which takes an attention mechanism and a bipartite graph embedding model BGEM as building blocks. Specifically, we adopt an attention mechanism to learn each user's social influence and adapt their social influences to different groups and develop a novel deep social influence learning framework to exploit and integrate users' global and local social network structure information to further improve the estimation of users' social influences. BGEM is extended to model group-item interactions. In order to overcome the limitation and sparsity of the interaction data generated by occasional groups, we propose two model optimization approaches to seamlessly integrate the user-item interaction data. We create two large-scale benchmark datasets and conduct extensive experiments on them. The experimental results show the superiority of our proposed SIGR by comparing with state-of-the-art group recommender models.
Concepts of the text editor Lara (1985)

Lara, a text editor developed for the Lilith workstation, exemplifies the principles underlying modern text-editor design: a high degree of interactivity, an internal data structure that mirrors currently displayed text, and extensive use of bitmap controlled displays and facilities.
Cyborg beast: a low-cost 3d-printed prosthetic hand for children with upper-limb differences (2015)

This investigation describes a low-cost 3D-printed prosthetic hand for children and proposes a distance fitting procedure. The Cyborg Beast prosthetic hand and the proposed distance-fitting procedures may represent a possible low-cost alternative for children in developing countries and those who have limited access to health care providers. Further studies should examine the functionality, validity, durability, benefits, and rejection rate of this type of low-cost 3D-printed prosthetic device.
Control of gal transcription through DNA looping: inhibition of the initial transcribing complex. (1992)

Involvement of DNA looping between two spatially separated gal operators, OE and OI, in repression of the gal operon has been demonstrated in vivo. An in vitro transcription assay using a minicircle DNA containing the gal promoter region with lac operators was employed to elucidate the molecular mechanism of repression. Wild-type lac repressors (LacI+ protein molecules), which are capable of associating into a tetramer and forming a DNA loop, repressed transcription from promoter sites P1 and P2, whereas a non-looping lac repressor mutant (LacI(adi)) failed to show normal repression of both of the gal promoters. Thus a DNA loop is also required for repression of transcription in vitro. Repression mediated by DNA looping resulted in the inhibition of the synthesis of complete as well as aborted transcripts, demonstrating that the repressive action was on the formation or activity of the initial transcribing complex. Under similar conditions, the gal repressor (GalR protein) did not repress the gal promoters effectively, apparently because it failed to loop DNA containing gal operators in the purified system. The component(s) or conditions that aid GalR in DNA looping remain to be identified.
Soil improvement using plant-derived urease-induced calcium carbonate precipitation (2018)

This study addresses a soil improvement technique using plant-derived urease-induced calcium carbonate (CC) precipitation (PDUICCP) as an alternative to microbially induced carbonate precipitation (MICP). A crude extract of crushed watermelon (Citrullus lanatus) seeds was used as the urease source along with calcium chloride (CaCl2) and urea (CO (NH2)2) for CC precipitation. Test specimens (φ = 2.3 cm, h = 7.1 cm) made from commercially available Mikawa sand (mean diameter, D50 = 870 µm) were cemented, and estimated unconfined compressive strength (UCS) of several kPa to MPa was obtained by changing the concentration of CaCl2- urea, urease activity, curing time, and temperature. The increase of curing time and that of the CaCl2-urea concentration from 0.3 M to 0.7 M caused an increase in estimated UCS value. The average estimated UCS obtained after 14 days’ curing time for 0.7 M CaCl2-urea and 3.912 U/mL urease was around 3.0 MPa and for 0.3 and 0.5 M CaCl2-urea and 0.877 U/mL urease, it was around 1.5–2.0 MPa at 25 °C. By changing each of the abovementioned parameters, it may be possible to apply this method for strength improvement of loose sand, to mitigate the liquefaction, protection and restoration of limestone monuments and statuaries, and artificial soft rock formations. Crude urease from crushed watermelon seeds has the potential to replace commercially available urease for carbonate precipitation and for use as a low environmental impact type soil improvement method.
Comparisons of Polymer/Gas Partition Coefficients Calculated from Responses of Thickness Shear Mode and Surface Acoustic Wave Vapor Sensors (1998)

Apparent partition coefficients, K, for the sorption of toluene by four different polymer thin films on thickness shear mode (TSM) and surface acoustic wave (SAW) devices are compared. The polymers examined were poly(isobutylene) (PIB), poly(epichlorohydrin) (PECH), poly(butadiene) (PBD), and poly(dimethylsiloxane) (PDMS). Independent data on partition coefficients for toluene in these polymers were compiled for comparison, and TSM sensor measurements were made using both oscillator and impedance analysis methods. K values from SAW sensor measurements were about twice those calculated from TSM sensor measurements when the polymers were PIB and PECH, and they were also at least twice the values of the independent partition coefficient data, which is interpreted as indicating that the SAW sensor responds to polymer modulus changes as well as to mass changes. K values from SAW and TSM measurements were in agreement with each other and with independent data when the polymer was PBD. Similarly, K values from the PDMS-coated SAW sensor were not much larger than values from independent measurements. These results indicate that modulus effects were not contributing to the SAW sensor responses in the cases of PBD and PDMS. However, K values from the PDMS-coated TSM device were larger than the values from the SAW device or independent measurements, and the impedance analyzer results indicated that this sensor using our sample of PDMS at the applied thickness did not behave as a simple mass sensor. Differences in behavior among the test polymers on SAW devices are interpreted in terms of their differing viscoelastic properties.
Complete Genome Sequence and Lytic Phase Transcription Profile of a <i>Coccolithovirus</i> (2005)

The genus Coccolithovirus is a recently discovered group of viruses that infect the globally important marine calcifying microalga Emiliania huxleyi. Among the 472 predicted genes of the 407,339-base pair genome are a variety of unexpected genes, most notably those involved in biosynthesis of ceramide, a sphingolipid known to induce apoptosis. Uniquely for algal viruses, it also contains six RNA polymerase subunits and a novel promoter, suggesting this virus encodes its own transcription machinery. Microarray transcriptomic analysis reveals that 65% of the predicted virus-encoded genes are expressed during lytic infection of E. huxleyi.
Multiple sclerosis–associated retrovirus (MSRV) in Sardinian MS patients (2002)

Blood and CSF of Sardinian patients with MS and neurologic control subjects were tested for MS-associated retrovirus (MSRV). CSF detection in MS was 50% at clinical onset, increasing with temporal disease progression, and 40% in control subjects. In blood, MSRV was detected in all MS patients, in most patients with inflammatory neurologic diseases, and rarely in healthy blood donors. MSRV may represent a marker of neurologic diseases of inflammatory origin.
A biomimetic soft fingertip applicable to haptic feedback systems for texture identification (2013)

Humans recognize textures using the tactile data obtained from the human somatosensory system. Recognition of textures allows humans discriminate objects and materials. Moreover, by understanding the object's or material's texture, the human intuitively estimates roughness and the friction properties of the object or the material. This ability is necessary for object manipulative tasks. Likewise artificial haptic systems too, should have the ability to encode textures and feedback those data to haptic applications such as haptic displays. In this paper a biomimetic soft fingertip sensor that can be used in above haptic systems is introduced. The fingertip has the ability to detect force and vibration modalities. We propose three features calculated from the covariance signal of two adjacent accelerometers in the fingertip to use in texture identification. The covariance signal is transformed using Discrete Wavelet Transform (DWT) and the three features mentioned below are calculated. The mean and variance of the approximate signal, and the energies of the detailed signal are chosen as features. Then, the proposed features were validate by using those in an Artificial Neural Network (ANN) to classify seven wood samples. The results showed a 65% success rate in classifying wood samples and that the proposed features are acceptable to encode textures.
Generalized Curvilinear Diffraction Gratings: I. Image diffraction patterns (1983)

Abstract This paper is the first in a series on the diffraction and imaging properties of generalized curvilinear diffraction gratings. The ‘image diffraction pattern’ (IDP) of a generalized grating is defined as the optical image that is observed by the naked eye focused on the grating when it is illuminated by an arbitrarily extended diffuse source. In this paper, a general theory of the IDP is derived in both the scalar wave and geometric optics approximations. As an application of the theory, it is shown how the IDP of a generalized grating may be simulated by an optical data processing system in which the Fresnel transform of a low line density representation of the grating is filtered by an aperture of the same shape and orientation as the source. The theory is shown to lead to a simple explanation of the moiré effect first observed by Hamann and to a new technique for performing optical map transformations. As a practical test on the theory, the IDP of a circular diffraction grating is calculated and shown to be in good agreement with experiment.
Nitrate In Drilling Fluid As A Tracer Ion (1971)

Nitrate as a tracer ion in drilling muds offers a simple and inexpensive method to distinguish filtrate from formation water, and provides the information needed to calculate the absolute formation water salinity from drill stem and wire-line formation test recoveries. The technique and interpretation of nitrate spiking are presented in several case histories.
Regulation of tumor necrosis factor (TNF) release by murine peritoneal macrophages: role of cell stimulation and specific phagocytic plasma membrane receptors (1991)

In spite of the physiologic and pathologic importance of tumor necrosis factor (TNF), the cellular factors that govern its release by macrophages (M phi) are poorly understood, in comparison with other secretory products. We have studied the role of M phi heterogeneity and of plasma membrane receptors in regulating TNF release in vitro. Resident and various exudate murine peritoneal M phi populations were challenged with lipopolysaccharide (LPS) or different phagocytic particles, and TNF release assayed by cytotoxicity for L-929 fibroblasts. Resident peritoneal M phi (RPM phi) released a small amount of TNF in response to LPS whereas thioglycollate-elicited M phi (TPM phi) released high levels of TNF (5000 U/3 x 10(5) M phi/ml). M phi elicited by Bio-Gel polyacrylamide beads (BgPM phi), another nonspecific inflammatory stimulus, or early in the course of intraperitoneal Bacillus Calmette-Guérin infection, before recruited cells become immunologically activated, released tenfold less TNF after the same stimulus. By contrast, TNF release in response to various phagocytic triggers was similar (approximately 300-600 U/3 x 10(5) M phi/ml) in all M phi populations including RPM phi. The response by BgPM phi to LPS was enhanced by pre-treatment in vitro with interferon-gamma or thioglycollate broth. With respect to phagocytic receptor triggering we found that complement receptor type 3 (CR3) ligation or latex uptake did not mediate release of significant quantities of TNF (less than 48 U/3 x 10(5) M phi/ml) by any M phi, whereas ligation of the Fc receptor for IgG1/IgG2b subclasses or of receptors for zymosan particles sufficed, in the absence of ingestion, to induce release of circa 500 U/3 x 10(5) M phi/ml TNF by all M phi tested. Our studies show that M phi vary in respect to priming for TNF release and that heterogeneity should be related to a particular triggering stimulus. Furthermore, the capacity of some M phi populations to release unusually high levels of TNF depends on immune or nonspecific stimuli subsequent to the process of inflammatory recruitment.
A comparison of meta-analysis methods for detecting differentially expressed genes in microarray experiments (2008)

We comparatively evaluate the three methods; t-based hierarchical modeling, rank products and Fisher's Inverse chi(2) test with P-values from either the t-based or the rank product method. A simulation study shows that the rank product method, in general, has higher sensitivity and selectivity than the t-based method in both individual and meta-analysis, especially in the setting of small sample size and/or large between-study variation. Not surprisingly, Fisher's chi(2) method highly depends on the method used in the individual analysis. Application to real datasets demonstrates that meta-analysis achieves more reliable identification than an individual analysis, and rank products are more robust in gene ranking, which leads to a much higher reproducibility among independent studies. Though t-based meta-analysis greatly improves over the individual analysis, it suffers from a potentially large amount of false positives when P-values serve as threshold. We conclude that careful meta-analysis is a powerful tool for integrating multiple array studies.
Quanta data storage: an information processing and transportation architecture for storage area networks (2005)

A new architecture for storage area networks (SANs) is proposed for providing efficient information processing and transportation. We deviate from the byte stream oriented transmission control protocol (TCP) transport mechanism to more storage friendly block oriented transport. Data is processed, encrypted, error checked, redundantly encoded, and stored in fixed size blocks called quanta. Each quantum is processed by an effective cross-layer protocol that collapses the protocol stack for security, iWARP and iSCSI functions, transport control, and even redundant arrays of inexpensive disk (RAID) storage. This streamlining produces a highly efficient protocol with fewer memory copies and places most of the computational burden and security safeguard on the client, while the target stores quanta from many clients with minimal processing. We propose a new network RAID storage method using the quantum concept. Also, we unify error control and flow control of the iSCSI and TCP protocols in a manner we believe is more suitable for high data rate and low latency storage applications.
A model investigation of interannual winter rainfall variability over southwestern South Africa and associated ocean-atmosphere interaction (2003)

We have investigated the variability of inter-annual winter rainfall over the southwestern Cape region of South Africa and associated large-scale atmosphere-ocean interaction upstream over the South Atlantic using the HadAM3 atmospheric general circulation model. This model was run for the period from 1990 to 1999 using mean monthly global sea-surface temperature (SST) as surface boundary condition over the global ocean. Diagnostics of winter (May to September) model output averaged over 1990-99 suggest that the HadAM3 model represents the general circulation in the South Atlantic / African sector reasonably well for this season at least. In addition, model years with wet and dry winters over the study area tended also to be those that were observed to be anomalously wet or dry. Wet minus dry season composite fields were used to investigate the model's inter-annual variability. The composite difference fields for low- and mid-level winds, sea-level pressure, and moisture flux all indicated wet winters being associated with increased inflow from tropical South America (originating in the equatorial western Atlantic at low levels) contributing relatively moist air to the westerly flow heading towards the southwestern Cape. A stronger jet over the South Atlantic promoted the passage of storms towards the Cape. Large areas of cyclonic vorticity anomalies, enhanced eddy activity, increased thickness in the lower atmosphere and low-level convergence near and upstream of the southwestern Cape in the model composite differences all favoured increased storm systems as well as their local intensification, implying enhanced rainfall. The results presented here suggest that the model can represent the interannual variability of winter rainfall over the study region and shed light on the mechanisms potentially associated with anomalously wet winters there.
An Efficient Segmentation Method for Overlapping Chromosome Images (2014)

Systems are being developed to automate the task of classification of chromosomes. The chromosomes are nonrigid material and they are several times touching each other or they overlap each other in the metaphase images. So different techniques are required to segregate the overlapping chromosomes. This paper presents a novel method for segmenting chromosomes based upon computational geometry. In the proposed approach first the contour line is traced for the overlapping chromosomes and then all the cut points are traced for the overlapping chromosomes. Then based on computational geometry method a specific number of cut points are selected and they are used for separating the two chromosomes. We have found that 87.4% of the images were correctly segmented using the proposed method.
The anti-inflammatory limb of the immune response in preterm labor, intra-amniotic infection/inflammation, and spontaneous parturition at term: A role for interleukin-10 (2008)

The anti-inflammatory cytokine IL-10 is detectable in the amniotic fluid of normal pregnant women. Spontaneous parturition at term and in preterm gestation is associated with increased amniotic fluid concentrations of IL-10. IAI (preterm and at term) is also associated with increased amniotic fluid concentrations of IL-10. We propose that IL-10 has a role in the regulation of the immune response in vivo by initiating actions that dampen inflammation.
Fabrication and characteristics of a 4H-SiC junction barrier Schottky diode (2011)

4H-SiC junction barrier Schottky (JBS) diodes with four kinds of design have been fabricated and characterized using two different processes in which one is fabricated by making the P-type ohmic contact of the anode independently, and the other is processed by depositing a Schottky metal multi-layer on the whole anode. The reverse performances are compared to find the influences of these factors. The results show that JBS diodes with field guard rings have a lower reverse current density and a higher breakdown voltage, and with independent P-type ohmic contact manufacturing, the reverse performance of 4H-SiC JBS diodes can be improved effectively. Furthermore, the P-type ohmic contact is studied in this work.