gebhart/patrepeval huggingface dataset:
The endopeptidase activity and the activation by Cl− of angiotensin-converting enzyme is evolutionarily conserved: purification and properties of an an angiotensin-converting enzyme from the housefly, <i>Musca domestica</i> (1996)

A soluble 67 kDa angiotensin-converting enzyme (ACE) has been purified by lisinopril-Sepharose affinity column chromatography from adult houseflies, Musca domestica. The dipeptidyl carboxypeptidase activity towards benzoyl-Gly-His-Leu was inhibited by captopril (IC50 50 nM) and fosinoprilat (IC50 251 nM), two inhibitors of mammalian ACE, and was activated by Cl- (optimal Cl- concentration 600 mM). Musca ACE removed C-terminal dipeptides from angiotensin I, bradykinin [Leu5]enkephalin and [Met5]enkephalin and also functioned as an endopeptidase by hydrolysing dipeptideamides from [Leu5]enkephalinamide and [Met5]enkephalinamide, and a dipeptideamide and a tripeptideamide from substance P. Musca ACE was also able to cleave a tripeptide from both the N-terminus and C-terminus of luteinizing hormone-releasing hormone, with C-terminal hydrolysis predominating. Maximal N-terminal tripeptidase activity occurred at 150 mM NaCl, whereas the C-terminal tripeptidase activity continued to rise with increasing concentration of Cl- (0-0.5 M). Musca ACE displays properties of both the N- and C-domains of human ACE, indicating a high degree of conservation during evolution of the substrate specificity of ACE and its response to Cl-.
Structural Studies of <i>N</i>,<i>N</i>′‐Di(<i>ortho</i>‐fluorophenyl)formamidine Group 1 Metallation (2003)

The treatment of N,N'-di(ortho-fluorophenyl)formamidine (HFPhF) in tetrahydrofuran with equimolar amounts of n-butyllithium, sodium bis(trimethylsilyl)amide or potassium bis(trimethylsilyl)amide affords the colourless crystalline formamidinate complexes [Li(FPhF)(thf)] (1), [Na(FPhF)(thf)] (2) and [K(FPhF)] (5). Low-temperature preparation of 2 in diethyl ether yields the Et(2)O adduct [Na(FPhF)(Et(2)O)] (3). At ambient temperature the sodium fluoride inclusion complex [Na(3)(FPhF)(3)(Et(2)O)(NaF)] (4) is also formed. Spectroscopic ((1)H, (13)C and (19)F((1)H) NMR) data for 1-5, microanalytical analyses for compounds 1, 2 and 5 and X-ray structure determinations for 1, 3-5 confirm the formulae of these species. In the solid-state, 1 and 3 possess a dimeric nature in which the formamidinate ligands coordinate through mu(2):eta(2):eta(1) (1) and mu(2):eta(2):eta(2) (3) binding modes. These are enabled by partial ortho-fluoro donation. Compound 4, which is also dimeric, contains two trisodium tris(formamidinate) units that comprise mu(2):eta(2):eta(2)-FPhF ligands, a bridging diethyl ether moiety and an unprecedented mu(3):eta(2):eta(2):eta(2)-formamidinate donor. Together, these trinuclear units encapsulate two sodium fluoride units by eta(2)-N,N-formamidinate chelation of the sodium cations (thereby creating further mu(3):eta(2):eta(2):eta(2)-bound formamidinates) and fluoride-sodium interactions. Compound 5 extends the coordinative versatility of FPhF to mu(2):eta(4):eta(3) coordination by the generation of K(2)(mu(2):eta(4):eta(3)-FPhF)(2) units that exhibit eta(2)-arene interactions. Macromolecularly, the overlaying of these units affords a polymeric solvent-free structure that incites coordination of the FPhF ligands to metal atoms above and below the K(2)(FPhF)(2) plane. Overall, this generates a remarkable mu(4):eta(4):eta(3):eta(2):eta(1)-amidinate binding mode that incorporates both bridging and terminal fluorine donors. Compounds 1-5 are the first non-chromium complexes of N,N'-di(ortho-fluorophenyl)formamidinate.
State-of-the-art Anonymization of Medical Records Using an Iterative Machine Learning Framework (2007)

We can say that our system is competitive with the current state-of-the-art solutions, while we describe here several techniques that can be beneficial in other tasks that need to handle structured documents such as clinical records.
Pose-based SLAM with probabilistic scan matching algorithm using a mechanical scanned imaging sonar (2009)

This paper proposes a pose-based algorithm to solve the full SLAM problem for an autonomous underwater vehicle (AUV), navigating in an unknown and possibly unstructured environment. The technique incorporate probabilistic scan matching with range scans gathered from a mechanical scanning imaging sonar (MSIS) and the robot dead-reckoning displacements estimated from a Doppler velocity log (DVL) and a motion reference unit (MRU). The proposed method utilizes two extended Kalman filters (EKF). The first, estimates the local path travelled by the robot while grabbing the scan as well as its uncertainty and provides position estimates for correcting the distortions that the vehicle motion produces in the acoustic images. The second is an augment state EKF that estimates and keeps the registered scans poses. The raw data from the sensors are processed and fused in-line. No priory structural information or initial pose are considered. The algorithm has been tested on an AUV guided along a 600 m path within a marina environment, showing the viability of the proposed approach.
Characterization of non-planar shadow masked Al/sub x/Ga/sub 1-x/As structures by confocal photoluminescence microscopy (2002)

Confocal photoluminescence has been used to spatially resolve AlGaAs composition changes of 4% and quantum well thickness reductions of 70% in a non-planar structure created by vapor phase epitaxial shadow masking.
CYCLIC ORGANOPHOSPHORUS COMPOUNDS. PART XVI<sup>1</sup>. MASS SPECTROMETRIC FRAGMENTATION OF SOME 5,5-DIMETHYL-1,3,2-DIOXAPHOSPHORINAN 2-OXIDES AND 2-SULPHIDES (1981)

Abstract The mass spectra of seventeen 5,5-dimethyl-1,3,2-dioxaphosphorinan 2-oxides and nineteen 5,5-dimethyl-1,3,2-dioxa-phosphorinan 2-sulphides, mostly with amino substituents on phosphorus, have been determined. In some cases, interpretation of the spectra was aided by accurate mass measurements and by the examination of deuterated compounds. For the 2-sulphides, sulphur is lost either as such or as the thiol radical, both processes often being of weak intensity, and the thiol hydrogen appears to be derivable from either a ring methylene group or a C-5 methyl group. Loss of S or HS occurs more strongly for the phosphoramidothionates which, together with the phosphoramidates, also fragment to an important extent in the amido substituent with retention of the dioxaphosphorinan ring; P[sbnd]N bond cleavage is also observed. For the 2-thiones, the ions at m/e 165 (14; R[dbnd]H) and 133 (15; R[dbnd]H) are characteristic.
Metal ion binding properties of poly(N-vinylimidazole) hydrogels (1998)

The ability of poly(N-vinylimidazole) hydrogels to bind Cu(II), Co(II), Ni(II), Zn(II), Cd(II), Pb(II), Hg(II), Na(I) and Ca(II) cations, as well as uranyl, vanadium, rhenium, and molybdenum complexes, was studied by a batch equilibrium procedure using atomic absorption spectroscopy and UV-Vis spectrophotometry. The optimum pH for ion adsorption was determined in any case. The influence of the crosslinking degree of the hydrogel on the sorption kinetics and the sorption capacity at equilibrium were also studied. Sorption from the binary mixture Cu(II) + U(VI) was also analyzed at the optimum pH. Elution of the ions adsorbed from single and binary solutions was achieved in all cases. A selective desorption of loaded hydrogels with two types of ions was attained. The general conclusion is that poly(N-vinylimidazole) hydrogels are excellent materials for retention of all the ions studied here [except for Pb(II), Na(I), and Ca(II)]. The elution, which can be selective, allows regeneration of the hydrogel. © 1998 John Wiley & Sons, Inc. J Appl Polym Sci 67:1109–1118, 1998
ChemInform Abstract: Ligand Bite Angle Effects in Metal‐Catalyzed C—C Bond Formation (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Down's Syndrome and Alzheimer's disease: a review (1986)

Neuropathological change found in nearly all individuals with Down's Syndrome over the age of 35 years closely resembles that of Alzheimer's disease. The extent to which dementia occurs as a result of this change is unclear, and the studies which have investigated presumed cognitive deficits are reviewed. The theories put forward to explain the association between these two disorders and their possible significance to the understanding of the aetiology of Alzheimer's disease are discussed.
PERFLUOROETHER LIQUID AS A LONG-TERM VITREOUS SUBSTITUTE (1984)

A commercial perfluoroether liquid, Fomblin-H Fluorinated Fluid, which is transparent and viscous, was investigated as a possible long-term vitreous substitute. The material belongs to a family of perfluorocarbon derivatives that are generally inert and nontoxic. A space for the vitreous substitute was created in rabbit eyes by a vitreous compression technique using perfluoropropane gas. Fomblin caused gliosis of the retina at 1 month after intravitreous injection. Preretinal membrane formation and retinal disorganization and detachment occurred in two of four eyes enucleated at 3 months, and in all five eyes enucleated at 4 or 6 months. Vacuoles presumably filled with Fomblin were localized histopathologically within the retina. In control eyes injected with medical-grade silicone oil, abnormalities were limited to moderate edema of the nerve fiber and ganglion cell layer. Fomblin was not as well-tolerated by the rabbit retina as was medical-grade silicone oil. Fomblin is not a suitable vitreous substitute.
Analysis of structural response data using discrete modal filters (1991)

The application of reciprocal modal vectors to the analysis of structural response data is described. Reciprocal modal vectors are constructed using an existing experimental modal model and an existing frequency response matrix of a structure, and can be assembled into a matrix that effectively transforms the data from the physical space to a modal space within a particular frequency range. In other words, the weighting matrix necessary for modal vector orthogonality (typically the mass matrix) is contained within the reciprocal model matrix. The underlying goal of this work is mostly directed toward observing the modal state responses in the presence of unknown, possibly closed loop forcing functions, thus having an impact on both operating data analysis techniques and independent modal space control techniques. This study investigates the behavior of reciprocol modal vectors as modal filters with respect to certain calculation parameters and their performance with perturbed system frequency response data.
Evaluation of a novel in-vitro diagnostic device for the detection of urinary tract infections in diaper-wearing children (2012)

The evaluation shows that U-Test(®) is a safe and reliable device of high functionality and diagnostic performance for the detection of leucocytes and nitrite directly and without time delay in a child's diaper. This statement is based on a comprehensive comparison of the novel device with accepted diagnostic test systems and procedures based on the same dry chemistry technology. Due to its simplicity of use, U-Test(®) can be considered an alternative to the cumbersome procedures of urine collection by the bag-method or clean-catch followed by dipstick analysis for the presence of leucocytes and nitrite.
A Reliable Data-Based Bandwidth Selection Method for Kernel Density Estimation (1991)

SUMMARY We present a new method for data-based selection of the bandwidth in kernel density estimation which has excellent properties. It improves on a recent procedure of Park and Marron (which itself is a good method) in various ways. First, the new method has superior theoretical performance; second, it also has a computational advantage; third, the new method has reliably good performance for smooth densities in simulations, performance that is second to none in the existing literature. These methods are based on choosing the bandwidth to (approximately) minimize good quality estimates of the mean integrated squared error. The key to the success of the current procedure is the reintroduction of a non-stochastic term which was previously omitted together with use of the bandwidth to reduce bias in estimation without inflating variance.
The Influence of Vocal Qualities and Confirmation of Nonnative English-Speaking Teachers on Student Receiver Apprehension, Affective Learning, and Cognitive Learning (2011)

This study investigated the influence of teacher vocal qualities and confirmation behaviors on student learning. Students (N=197) enrolled in nonnative English-speaking teachers’ classes completed a battery of instruments. Results indicated that both vocal qualities and confirmation behaviors were negatively related to receiver apprehension, which in turn was negatively related to affective and cognitive learning. Receiver apprehension mediated the relationships of student learning with vocal qualities, but not with teacher confirmation. In addition to students’ perceptions, clinician observers’ ratings of vocal qualities were negatively related to receiver apprehension and positively associated with cognitive learning.
Local Features and Visual Words Emerge in Activations (2019)

We propose a novel method of deep spatial matching (DSM) for image retrieval. Initial ranking is based on image descriptors extracted from convolutional neural network activations by global pooling, as in recent state-of-the-art work. However, the same sparse 3D activation tensor is also approximated by a collection of local features. These local features are then robustly matched to approximate the optimal alignment of the tensors. This happens without any network modification, additional layers or training. No local feature detection happens on the original image. No local feature descriptors and no visual vocabulary are needed throughout the whole process. We experimentally show that the proposed method achieves the state-of-the-art performance on standard benchmarks across different network architectures and different global pooling methods. The highest gain in performance is achieved when diffusion on the nearest-neighbor graph of global descriptors is initiated from spatially verified images.
Low-level brightness-contrast illusions and non classical receptive field of mammalian retina (2005)

Among the visual illusions there is a class, which is known as low-level brightness contrast illusions. These illusions are processed probably at the retinal ganglion cell without necessitating any intervention from higher order cortical processing. The concept of classical receptive field of the ganglion cell, derived from early physiological studies, prompted the idea that a "Difference of Gaussian" or DoG model might reproduce the output of the ganglion cell. In spite of its many successes, the DoG model fails to explain some of these low level illusions. On the basis of recently available physiological data, we have modified the DoG model and have shown the efficacy of the modified model in understanding the low level illusions, a phenomenon that may have potential application in designing new robust visual capturing or display systems.
Prevalence of long‐term BK and JC excretion in HIV‐infected adults and lack of correlation with serological markers (1999)

The natural history of polyomavirus infection, and sensitivity of diagnostic assays remain unclear. A stratified group of 94 human immunodeficiency virus (HIV)-infected patients was studied for both virological and serological markers of active infection with both JC virus and BK virus. JC DNA was detected in the urine of 18 of 81 (22%) patients and BK DNA in 30 (37%) patients. Whilst patients with a low CD4 cell count (P = .009), CD4/CD8 ratio (P = .031) and β2M concentration (P = .042) were significantly more likely to be excreting BK, JC excretion did not correlate with any of the immunological markers measured. Furthermore, when all the immunological factors were taken into account, there was no association between either BK or JC excretion and age of the patient (P = .149 for BK, P = 0.891 for JC). BK IgM antibody was detected in only 3 of 30 (10%) BK excretors. JC IgM was detected in 5 of 18 (27.7%) JC excretors but also in 11 of 63 (17.5%) patients without demonstrable JC excretion. Therefore IgM was a very poor indicator of viruria. One year follow-up on a subset of patients showed that both DNA detection in urine and IgM antibody remain stable over many months despite falling CD4 cell counts, and would indicate that events leading to enhanced viral production probably occur early after HIV infection. Replication of JC virus in the brain leading to the onset of progressive multifocal leukoencephalopathy (PML) could not be predicted using any of the markers studied. J. Med. Virol. 59:474–479, 1999. © 1999 Wiley-Liss, Inc.
Ultrahigh-Speed Synthesis of Nanographene Using Alcohol In-Liquid Plasma (2012)

Ultrahigh-speed synthesis of high-crystallinity nanographene was realized using an alcohol in-liquid plasma, which was generated from a nonequilibrium microhollow atmospheric-pressure plasma with an ultrahigh electron density. The synthesis rates of carbon materials were 0.61 and 1.72 mg/min using ethanol and butanol, respectively. Multilayer nanographene structures obtained using ethanol had an interlayer spacing of 0.33 nm, corresponding to that of (002) planes in graphite. The G-, D-, D'-, and 2D-band peaks in the Raman spectrum also confirmed the formation of nanographene. The mechanism of gradual growth of six-membered ring structures was clarified by gas chromatography of the filtrate.
Low Loss and Low Vpi Thin Film Lithium Niobate on Quartz Electro-optic Modulators (2017)

Thin film lithium niobate (TFLN™) electro-optic modulators have potential for superior gain, bandwidth, linearity and impedance matching relative to semiconductor technologies. This paper reports TFLN modulators with optical loss < 0.5 dB/cm, Vpi-length of 2.2 V-cm, and 67 GHz operation.
All-printed thin-film transistors from networks of liquid-exfoliated nanosheets (2017)

All-printed transistors consisting of interconnected networks of various types of two-dimensional nanosheets are an important goal in nanoscience. Using electrolytic gating, we demonstrate all-printed, vertically stacked transistors with graphene source, drain, and gate electrodes, a transition metal dichalcogenide channel, and a boron nitride (BN) separator, all formed from nanosheet networks. The BN network contains an ionic liquid within its porous interior that allows electrolytic gating in a solid-like structure. Nanosheet network channels display on:off ratios of up to 600, transconductances exceeding 5 millisiemens, and mobilities of >0.1 square centimeters per volt per second. Unusually, the on-currents scaled with network thickness and volumetric capacitance. In contrast to other devices with comparable mobility, large capacitances, while hindering switching speeds, allow these devices to carry higher currents at relatively low drive voltages.
Organic synthesis by the Pummerer reaction. II. Synthesis of .alpha.-hydroxy acid derivatives from .beta.-keto sulfoxides (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOrganic synthesis by the Pummerer reaction. II. Synthesis of .alpha.-hydroxy acid derivatives from .beta.-keto sulfoxidesShinobu Iriuchijima, Keiko Maniwa, and Genichi TsuchihashiCite this: J. Am. Chem. Soc. 1975, 97, 3, 596–599Publication Date (Print):February 1, 1975Publication History Published online1 May 2002Published inissue 1 February 1975https://pubs.acs.org/doi/10.1021/ja00836a021https://doi.org/10.1021/ja00836a021research-articleACS PublicationsRequest reuse permissionsArticle Views411Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Pressure-Induced Site-Selective Disordering of<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:msub><mml:mi>Ge</mml:mi><mml:mn>2</mml:mn></mml:msub><mml:msub><mml:mi>Sb</mml:mi><mml:mn>2</mml:mn></mml:msub><mml:msub><mml:mi>Te</mml:mi><mml:mn>5</mml:mn></mml:msub></mml:math>: A New Insight into Phase-Change Optical Recording (2006)

We demonstrate that , the material of choice in phase-change optical recording (such as DVD-RAM), can be rendered amorphous by the application of hydrostatic pressure. It is argued that this structural change is due to a very strong second-nearest-neighbor Te-Te interaction that determines the long-range order in the metastable cubic phase of and also to the presence of vacancies. This newly discovered phenomenon suggests that pressure is an important factor for the formation of the amorphous phase which opens new insight into the mechanism of phase-change optical recording.
PRODUCT FULFILLMENT IN SUPPLY CHAINS SUPPORTING INTERNET‐RETAILING OPERATIONS (2003)

Customer service, based on economical logistics operations across the supply chain, is key to the realization of sustainable levels of profitability in Internet retailing. Concentrating on inventory and product‐release operations, an empirical simulation model suggests that inventory centralization and market demand growth positively affect the level of cost‐effective service received by online shoppers. The results also show that under increasing demand levels, Internet retailers can provide optimal service to consumers by fulfilling orders through inventories located at their own facilities and avoid relying on inventories held elsewhere in the supply chain.
Design of Algorithms to Extract Data from Capacitance Sensors to Measure Fastener Hole Profiles (1983)

This paper discusses algorithms used to process data from a multisegmented capacitance probe as the basis for a system for nondestructive testing of aircraft fastener holes. Measurement accuracies on the order of tenths of mils are achieved through a combination of accurate electronic measurement of capacity and use of the computer-implemented algorithms for estimating hole profiles. The estimation algorithms make possible the novel feature of allowing accurate determination of hole profiles for arbitrary positioning of the probe in the hole. The paper gives a brief description of the measurement system and the capacitance probe. The algorithms are discussed in detail and examples of measured profiles for known hole shapes are given.