gebhart/patrepeval huggingface dataset:
Learning Distributed Representations for Structured Output Prediction (2014)

In recent years, distributed representations of inputs have led to performance gains in many applications by allowing statistical information to be shared across inputs. However, the predicted outputs (labels, and more generally structures) are still treated as discrete objects even though outputs are often not discrete units of meaning. In this paper, we present a new formulation for structured prediction where we represent individual labels in a structure as dense vectors and allow semantically similar labels to share parameters. We extend this representation to larger structures by defining compositionality using tensor products to give a natural generalization of standard structured prediction approaches. We define a learning objective for jointly learning the model parameters and the label vectors and propose an alternating minimization algorithm for learning. We show that our formulation outperforms structural SVM baselines in two tasks: multiclass document classification and part-of-speech tagging.
The Historical Experience of the Transformation of the Asia-Pacific Order and Its Future Development Direction (2013)

This paper attempts to examine the dynamics and evolutional way of the Asia-Pacific regional order. In general, there have been three waves of regional order change since the 1970s. The first kind of regional order adjustment was the reconciliation between China and the U.S.A.-Japan alliance, which was a geopolitical arrangement driven by the strategic imbalance between the U.S.A. and the Soviet Union. The second one took place in the late 1980s with the rise of Japanese economic power, and the United States having succeeded in persuading Japan to 50 upgrade the U.S.A.-Japan alliance without any great change in the regional order. The most recent regional order adjustment continues to develop and initially emerged due to the quick and continuous rise of China. Due to the great scale and multi-dimensionality of the rise of China, Asia-Pacific regional order adjustment might change the global order in the near future. On the one hand, the third wave of regional order adjustment is driven by peaceful dynamics, and the current American hegemony cannot contain China’s rise through military force. On the other hand, the new regional order is directly based on the experiences of its two predecessors and tries to combine geopolitical balance with geo-economics. Focusing on the power transition between China and the U.S.A., many believe that regional order has disintegrated into “two Asias”, with China dominating economic growth and the United States providing security order. However, this kind of judgment is not a reality but merely speculation. Although China and the United States certainly play the greatest roles in future regional order formation, other regional countries still have their positions in the new regional order. The ideal regional order model in their minds is a much more balanced and stable relationship between the U.S.A. and China, not a conflictual and divided one. Moreover, an open regionalism may help them to play a functional role in regional order.
Systemic Hypothermia, but Not Regional Gut Hypothermia, Improves Survival from Prolonged Hemorrhagic Shock in Rats (2002)

Cooling the gut alone does not improve acute survival from HS, suggesting that early deaths are not secondary to gut ischemia. Mild systemic hypothermia allowed 100% survival from prolonged HS.
Development of Cassegrain type 0.9-m collimator (2005)

Collimator is essential to evaluate and assemble the other telescopes. Its diameter should be larger than that of the target telescope for the correct use. We are currently developing the Cassegrain type collimator of which diameter is 0.9 m. The primary mirror is light-weighted so that its weight is only 70 kg. Due to its structure, the primary mirror can be supported only at the backside of the mirror. This mirror is tested with the combination of null Hartmann test and interferometer. The secondary mirror is tested with a Hindle method. This method requires 600 mm high quality spherical mirror. The distance between the primary and secondary mirror is maintained by the Carbon composite material. The assembly of two mirrors is carried out by the computer aided alignment method. The whole structure is designed to maintain the performance of the collimator under +/-5 degrees of temperature variation.
Exclusive CX3CR1 dependence of kidney DCs impacts glomerulonephritis progression (2013)

DCs and macrophages both express the chemokine receptor CX3CR1. Here we demonstrate that its ligand, CX3CL1, is highly expressed in the murine kidney and intestine. CX3CR1 deficiency markedly reduced DC numbers in the healthy and inflamed kidney cortex, and to a lesser degree in the kidney medulla and intestine, but not in other organs. CX3CR1 also promoted influx of DC precursors in crescentic glomerulonephritis, a DC-dependent aggressive type of nephritis. Disease severity was strongly attenuated in CX3CR1-deficient mice. Primarily CX3CR1-dependent DCs in the kidney cortex processed antigen for the intrarenal stimulation of T helper cells, a function important for glomerulonephritis progression. In contrast, medullary DCs played a specialized role in inducing innate immunity against bacterial pyelonephritis by recruiting neutrophils through rapid chemokine production. CX3CR1 deficiency had little effect on the immune defense against pyelonephritis, as medullary DCs were less CX3CR1 dependent than cortical DCs and because recruited neutrophils produced chemokines to compensate for the DC paucity. These findings demonstrate that cortical and medullary DCs play specialized roles in their respective kidney compartments. We identify CX3CR1 as a potential therapeutic target in glomerulonephritis that may involve fewer adverse side effects, such as impaired anti-infectious defense or compromised DC functions in other organs.
Application of Micro-Proppant to Enhance Well Production in Unconventional Reservoirs: Laboratory and Field Results (2015)

Abstract As more wells are drilled and completed in tight, brittle formations, operators rely more on small-sized proppants to help ensure the created complex fractures are propped, and to maintain conductive flow paths for production. Most microfractures generated in the far-field away from the primary fracture branches are believed to return to a closed state soon after the release of hydraulic pressure, unless propping agent has been successfully placed inside such fractures. This paper presents the results of laboratory study, numerical modeling, and field trials, to demonstrate and quantify the effectiveness of a new treatment method for enhancing conductivity of microfractures and primary fractures formed in tight formations, thus helping improve well production. The approach involves using a micro-proppant (MP) and an aqueous-based surface modification agent (ASMA) as part of the pad fluid stage to treat fracture faces of microfractures and leakoff induced fractures before placement of larger-sized proppant into the primary fractures. This coating causes the proppant particulates to adhere to the created fracture faces by forming partial monolayer, thus mitigating settling and enhancing vertical distribution in the fractures. During experimental testing, various shale core samples were split along the core length to create artificial fracture faces. These fracture faces were then exposed to MP or proppant slurry treated with an ASMA, and were then reassembled for core flow testing under closure stress. An effective permeability comparison of the fractured cores, with and without ASMA treated MP or proppant, demonstrated a dramatic effective permeability increase in fractures of the treated cores. Field treatments involved injection of pad fluid containing a low concentration of MP, with and without treating with ASMA in offset wells, to treat the microfractures formed in the far-field regions. Proppant slurry of larger size particulates (100-mesh and larger) then followed to prop the primary fractures and their branches. Production from wells treated with MP have shown to provide significant improvement in terms of liquids production compared to the production of control wells. Reservoir simulation performed in this complex retrograde condensate reservoir supports this result, with sensitivity testing showing that increasing the connected fracture area enables the production of more hydrocarbon liquids at higher sustained production rates.
Micronucleus as a Non-invasive Biomarker – A Review (2016)

Oral Cancer has a remarkably high incidence worldwide and a significant decrease in its mortality and morbidity rates has been established if it is diagnosed in early stages. There has been always a strong need to develop new, objective, non-invasive methods for its early detection. Micronucleus has come up in the recent past as non-invasive biomarker for diagnosis of not only malignant and pre-malignant lesions but also many other significant diseases. Micronucleus (“MN) is defined as microscopically visible, round or oval cytoplasmic chromatin mass next to the nucleus. Micronuclei Review Article Dev et al.; JAMPS, 6(4): 1-9, 2016; Article no.JAMPS.24136 2 (“MNi”) originate from aberrant mitoses and consist of eccentric chromosomes, chromatid fragments or whole chromosomes that have failed to be incorporated into the daughter nuclei during mitosis. The MN assay has been widely accepted as an in vitro genotoxicity test and a biomarker assay for genotoxic exposure and effect in humans. An attempt has been made to review the related studies, utilizing micronucleus assay of buccal cells as a novel marker of genotoxicity in head and neck region.
Data mining of temporal sequences for the prediction of infrequent failure events : application on floating train data for predictive maintenance (2014)

In order to meet the mounting social and economic demands, railway operators and manufacturers are striving for a longer availability and a better reliability of railway transportation systems. Commercial trains are being equipped with state-of-the-art onboard intelligent sensors monitoring various subsystems all over the train. These sensors provide real-time flow of data, called floating train data, consisting of georeferenced events, along with their spatial and temporal coordinates. Once ordered with respect to time, these events can be considered as long temporal sequences which can be mined for possible relationships. This has created a neccessity for sequential data mining techniques in order to derive meaningful associations rules or classification models from these data. Once discovered, these rules and models can then be used to perform an on-line analysis of the incoming event stream in order to predict the occurrence of target events, i.e, severe failures that require immediate corrective maintenance actions. The work in this thesis tackles the above mentioned data mining task. We aim to investigate and develop various methodologies to discover association rules and classification models which can help predict rare tilt and traction failures in sequences using past events that are less critical. The investigated techniques constitute two major axes: Association analysis, which is temporal and Classification techniques, which is not temporal. The main challenges confronting the data mining task and increasing its complexity are mainly the rarity of the target events to be predicted in addition to the heavy redundancy of some events and the frequent occurrence of data bursts. The results obtained on real datasets collected from a fleet of trains allows to highlight the effectiveness of the approaches and methodologies used
The anticonvulsant, local anesthetic and hemodynamic properties of some chiral aminobutanol derivatives of xanthone. (2009)

In the present study, several pharmacological tests in animals were carried out to assess potential anticonvulsant, local anesthetic and hemodynamic activity of novel 2- and 4-substituted aminobutanol chiral derivatives of xanthone (hydrochlorides of: (R,S)-2-[(7-chloro)-2-xanthonemethyl)]-N-methylaminobutan-1-ol (MH-2(R,S)), (R,S)-2-(4-xanthonemethyl)-aminobutan-1-ol (MH-20(R,S)) and (R,S)-2-[(6-methoxy)-2-xanthonemethyl]-aminobutan-1-ol (MH-26(R,S)) and their pure enantiomers R and S). The obtained results provided evidence that the most interesting anticonvulsant (in maximal electroshock-test) activity was shown by compound MH-2(R), which in dose 100 mg/kg p.o., protected the mice against tonic cramp of extensors similarly as phenytoin. Moreover, this compound, in concentrations from 0.25 to 1%, also possessed high local anesthetic activity (in infiltration anesthesia), comparable to the reference compound, mepivacaine. All examined compounds suppressed the spontaneous locomotor activity in mice, especially compound MH-2(R,S) and MH-20(R,S), and their enantiomers. The impairment of motor coordination (in chimney test) for applied doses was not observed. Furthermore, compound MH-20(S) at dose corresponding to 1/10 LD50 displayed an interesting hemodynamic activity and significantly decreased systolic and diastolic blood pressure in rats. All examined compounds showed chronotropic negative effect in anesthetized rats ECG record. The most reducing heart frequency was observed for enantiomers S of aminobutanol derivatives of xanthone, especially MH-2(S). The LD50 values of the investigated compounds were comparable with LD50 value of the reference compound in local anesthesia tests--mepivacaine. These studies demonstrated different strength of enantiomers and racemic mixture in carried out tests, where the R enantiomers presented rather central and local anesthetic properties, whereas S enatiomers influenced the hemodynamic activity.
Homology modeling and molecular dynamics simulations of the α1 glycine receptor reveals different states of the channel (2007)

Homology modeling is used to build initial models of the transmembrane domain of the human alpha1 glycine receptor (GlyR) based on the most recently published refined structure of nAChR (PDB ID: 2BG9). Six preliminary GlyR models are constructed using two different approaches. In one approach, five different homopentamers are built by symmetric assembly of alpha1 GlyR subunits using only one of the five unique chains of nAChR as a template. In a second approach, each nAChR subunit serves as a template for an alpha1 GlyR subunit. All six initial GlyR constructs are then embedded into a hydrated POPC lipid bilayer and subjected to molecular dynamics simulation for at least six nanoseconds. Each model is stable throughout the simulation, and the final models fall into three distinct categories. Homopentameric GlyR bundles using a single alpha nAChR subunit as a template appear to be in an open conformation. Under an applied external potential, permeation of Cl(-) ions is observed within several ns in a channel built on an alpha chain. Model channels built on non-alpha chains have a constriction either near the intracellular mouth or more centrally located in the pore domain, both of which may be narrow enough to close the channel and whose locations correspond to putative gates observed in nicotinicoid receptors. The differences between these three general models suggest that channel closure may be effected by either rotation or tangential tilting of TM2.
Genomic Aberrations Occurring in Subsets of Serrated Colorectal Lesions but not Conventional Adenomas (2013)

A subset of aggressive colorectal cancers exhibit BRAF mutation, MLH1 methylation, and a CpG island methylator phenotype (CIMP), but precursors are poorly established. In this study, we determined the status of these markers in colorectal polyps and evaluated associated risk factors. The study included 771 polyp cases and 1,027 controls who were ages 24 to 80 years, part of a group health program, received a colonoscopy from 1998 to 2007, and completed a structured questionnaire assessing risk factors. Following standard pathology review, polyps were assayed for BRAF mutation (V600E) and tested for MLH1 and CIMP methylation, the latter including the genes, CACNA1G, IGF2, NEUROG1, RUNX3, and SOCS1. Polytomous logistic regression was used to estimate ORs and 95% confidence intervals for the association between molecularly defined subsets of polyps and potential risk factors. There were 580 conventional adenomas and 419 serrated lesions successfully assayed. For adenomas, the prevalence of each marker was ≤1%. In contrast, 55% of serrated lesions harbored mutant BRAF, 26% were CIMP-high, and 5% had methylated MLH1. In these lesions, the highest prevalence of markers was in sessile-serrated polyps (SSP) of ≥10 mm that were in the right-side/cecal regions of the colon. Risk factors for CIMP-high-serrated lesions included Caucasian race, current smoking status, and a history of polyps, whereas for serrated lesions with mutant BRAF, the significant risk factors were male sex, current smoking status, obesity, and a history of polyps. Our results suggest that SSPs and other large, right-sided serrated lesions have a unique molecular profile that is similar to CIMP-high, BRAF-mutated colorectal cancers.
CELLO-a powerful operations tool for trouble-shooting in cellular systems (2003)

The software package CELLO is described as a traffic analysis tool for cellular mobile telephony. It is based on the function 'cell traffic recording' in the AXE mobile telephone switching office, and runs on the MS-DOS family of computers. CELLO is used to extract and present traffic data from an operating cellular system so that the system engineers can analyze the performance of the system or investigate various types of system malfunctions.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Air/fuel sensors based on Pt- and TiO2-doped Nb2O5 film (1998)

In this paper we describe the preparation of TiO2-doped Nb2O5 thin film using the ion-beam-enhanced deposition (IBED) technique, and the development of a new automobile air/fuel (A/F) sensor with an additionally integrated platinum temperature sensor and a Pt heater. The resistive jump at the stoichiometric point in the characteristic curve is three orders of magnitude. The response time of the sensor is 10 and 100 ms when the atmosphere is changed from lambda = 0.9 to 1.1 and vice versa, respectively. The sensor performance stabilized after 7 measurements. Preliminary results indicate that this sensor has the potential to monitor the lambda value of automobile exhaust gas.
Automatic anatomy recognition on CT images with pathology (2016)

Body-wide anatomy recognition on CT images with pathology becomes crucial for quantifying body-wide disease burden. This, however, is a challenging problem because various diseases result in various abnormalities of objects such as shape and intensity patterns. We previously developed an automatic anatomy recognition (AAR) system [1] whose applicability was demonstrated on near normal diagnostic CT images in different body regions on 35 organs. The aim of this paper is to investigate strategies for adapting the previous AAR system to diagnostic CT images of patients with various pathologies as a first step toward automated body-wide disease quantification. The AAR approach consists of three main steps – model building, object recognition, and object delineation. In this paper, within the broader AAR framework, we describe a new strategy for object recognition to handle abnormal images. In the model building stage an optimal threshold interval is learned from near-normal training images for each object. This threshold is optimally tuned to the pathological manifestation of the object in the test image. Recognition is performed following a hierarchical representation of the objects. Experimental results for the abdominal body region based on 50 near-normal images used for model building and 20 abnormal images used for object recognition show that object localization accuracy within 2 voxels for liver and spleen and 3 voxels for kidney can be achieved with the new strategy.
Effect of cashew nut shell liquid (CNSL) on properties of phenolic resins (1996)

Cashew nut shell liquid (CNSL) is a natural product, and because of its phenolic nature it undergoes reactions similar to those of phenol. The cost of CNSL is much less than phenol. The effect of replacement of phenol by CNSL on the properties of novolak and resole resins was experimentally investigated. © 1996 John Wiley & Sons, Inc.
A 6-level Flying Capacitor Multi-level Converter for Single Phase Buck-type Power Factor Correction (2019)

This work investigates behavior of flying capacitor multi-level (FCML) converters in single phase buck-type power factor correction (PFC) applications. Recent developments in FCML converters using GaN transistors are leveraged to improve power density of a single-phase 240 V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">RMS</sub> ac to direct 48 V dc conversion stage in data center power delivery applications. Here, we experimentally demonstrate this concept by using a digitally controlled 6-level FCML converter. The experimental prototype achieves 163 W/in <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> by box volume excluding heat sink and twice-line frequency energy buffer. A key contribution of this work is experimental exploration of flying capacitor natural balancing of an FCML buck converter in a single-phase ac-dc conversion where the flying capacitor voltages must swing at 120 Hz.
Enhanced Expression of Fibroblast Growth Factor Receptor 3 IIIc Promotes Human Esophageal Carcinoma Cell Proliferation (2015)

Deregulated expression of fibroblast growth factor receptors (FGFRs) and their ligands plays critical roles in tumorigenesis. The gene expression of an alternatively spliced isoforms of FGFR3, FGFR3IIIc, was analyzed by RT-PCR in samples from patients with esophageal carcinoma (EC), including esophageal squamous cell carcinoma (ESCC) and adenocarcinoma (EAC). The incidence of FGFR3IIIc was higher in EC [12/16 (75%); p=0.073] than in non-cancerous mucosa (NCM) [6/16 (38%)]. Indeed, an immunohistochemical analysis of early-stage ESCC showed that carcinoma cells expressing FGFR3IIIc stained positively with SCC-112, a tumor marker, and Ki67, a cell proliferation marker, suggesting that the expression of FGFR3IIIc promotes cell proliferation. We used EC-GI-10 cells endogenously expressing FGFR3IIIc as a model of ESCC to provide mechanistic insight into the role of FGFR3IIIc in ESCC. The knockdown of endogenous FGFR3 using siRNA treatment significantly abrogated cell proliferation and the overexpression of FGFR3IIIc in cells with enhanced cell proliferation. EC-GI-10 cells and ESCC from patients with EC showed endogenous expression of FGF2, a specific ligand for FGFR3IIIc, suggesting that the upregulated expression of FGFR3IIIc may create autocrine FGF signaling in ESCC. Taken together, FGFR3IIIc may have the potential to be an early-stage tumor marker and a molecular target for ESCC therapy.