gebhart/patrepeval huggingface dataset:
Partition site of the P1 plasmid. (1987)

We have defined a minimal partition site, parS, from the plasmid P1. It contains sufficient cis-acting information to direct accurate segregation of low-copy-number plasmids that contain it as long as the two essential P1 Par proteins are supplied in trans. The site is, at most, 34 base pairs and contains a perfect 13-base-pair inverted repeat. Site-directed mutations were made within the repeat sequence that abolished activity whether or not the symmetry of the palindrome was maintained. Partition appears to be a competitive process, as differentially marked plasmids carrying the same type of partition site are not independently segregated but are randomly distributed with respect to each other. We have studied competition between plasmids carrying various fragments encompassing the parS site. As expected, two plasmids carrying the minimal parS site compete with each other. However, a sequence that lies to the left of the minimal parS site acts as a major modulator of this competition, changing the specificity of the competitive effect completely. Thus, this adjacent sequence appears to be an important determinant of the specificity of the wild-type P1 partition system without being necessary for its efficient function.
A Simple Alkene -Catalyzed Reduction of Aromatic Esters to Alcohols by Zinc Borohydride (1997)

Abstract Reactivity of Zn(BH4)2 was modified by adding cyclohexene to achieve the reduction of aromatic esters to alcohols which reaction was not possible previously because of the mild nature of the reagent. Functional groups like Cl and nitro were tolerated. Notes The reductions were carried out using stoichiometric quantities of hydride using 10 mole% of cyclohexene as catalyst; the products were characterized by spectral data, melting point and by comparison with standard samples.
Validity of uniform quantization error model for sinusoidal signals without and with dither (1989)

A technique is presented for determining the probability density function (PDF) and variance of the quantization error of a sinusoidal signal applied to a uniform quantizer, namely, an ideal analog-digital converter. The results are the basis for determining the validity of the uniform quantization noise model for this class of signals. When dither is used it tends to decorrelate quantization error and the input signal. The effect of added uniform dither on the PDF of the quantizer input is investigated, as well as the PDF of the quantization error corresponding to the dithered sinusoid. The results prove the validity of the uniform quantization model in this case.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Regulatory Perspective on Bioassay Implementation Strategies for Potency Evaluation of Biopharmaceuticals (2021)

Guidance for Industry 1 INDs for Phase 2 and Phase 3 Studies Chemistry, Manufacturing, and Controls InformationThis guidance represents the Food and Drug Administration's (FDA's) current thinking on this topic.It
Measurement of the 1<i>S</i>-2<i>S</i>frequency in atomic hydrogen (1986)

We report on a first precise measurement of the 1S-2S energy interval in atomic hydrogen. Observing the 1S-2S transition in an atomic beam by pulsed Doppler-free two-photon spectroscopy and using an interferometrically calibrated absorption line of $^{130}\mathrm{Te}_{2}$ at 486 nm as the reference, we measure the frequency f(1S-2S)=2 466 061 395.6(4.8) MHz. Using the calculated 1S Lamb shift, we obtain a value for the Rydberg constant, ${\mathrm{R}}_{\mathrm{\ensuremath{\infty}}}$=109 737.314 92(22) ${\mathrm{cm}}^{\mathrm{\ensuremath{-}}1}$, which is not in good agreement with the most recent previous measurement.
On-device objective-C application optimization framework for high-performance mobile processors (2014)

Smartphones provide applications that are increasingly similar to those of interactive desktop programs, providing rich graphics and animations. To simplify the creation of these interactive applications, mobile operating systems employ high-level object-oriented programming languages and shared libraries to manipulate the device's peripherals and provide common user-interface frameworks. The presence of dynamic dispatch and polymorphism allows for robust and extensible application coding. Unfortunately, the presence of dynamic dispatch also introduces significant overheads during method calls, which directly impact execution time. Furthermore, since these applications rely heavily on shared libraries and helper routines, the quantity of these method calls is higher than those found in typical desktop-based programs. Optimizing these method calls centrally before consumers download the application onto a given phone is exacerbated due to the large diversity of hardware and operating system versions that the application could run on. This paper proposes a methodology to tailor a given Objective-C application and its associated device-specific shared library codebase using on-device post-compilation code optimization and transformation. In doing so, many polymorphic sites can be resolved statically, improving the overall application performance.
Electrostatic Assembly of Polymer/Single Walled Carbon Nanotube Multilayer Films (2002)

Polymer/carbon nanotube films have been formed by the alternate adsorption of the polyelectrolyte poly(diallyldimethylammonium chloride) and single walled carbon nanotubes (SWNT) onto substrates. Atomic force and scanning electron microscopies indicated that the adsorbed SWNTs were mostly in the form of 5−10 nm bundles and that uniform substrate coverage occurred. Absorbance spectrophotometry (UV−vis−NIR) confirmed that the adsorption technique resulted in uniform film growth. Characterization of the adsorbed SWNTs by X-ray photoelectron, Raman, and UV−vis−NIR spectroscopies suggested that they have a core of well ordered nanotubes covered by a layer of oxidized carbon nanotubes.
The Synthesis and Maturation of a Non-structural Extracellular Antigen from Tick-borne Encephalitis Virus and Its Relationship to the Intracellular NS1 Protein (1989)

The replication of flaviviruses results in the secretion of four virus-coded proteins into the extracellular environment. Three of these proteins, E, C and M (or pre-M), are found in purified virions. A fourth virus-specified extracellular protein which was not present in either the slowly sedimenting haemagglutinin particles or in virions is described. The relationship of this protein to the intracellular NS1 polypeptide was investigated along with its similarity to the soluble complement-fixing antigen (SCF) reported for mosquito-borne flaviviruses. The difference in the Mr of NS1 and SCF is the result of additional glycosylation of SCF, mostly by the addition of fucose molecules. The synthesis of E and NS1 is sequential but their secretion is simultaneous, suggesting a role for NS1 in virion protein transport or virion release.
Silencing of the ADNP‐family member, ADNP2, results in changes in cellular viability under oxidative stress (2007)

Activity-dependent neuroprotective protein (ADNP) 2 (KIAA0863; ZNF508) gene, a homeobox-profile containing gene, was identified in a screen for homologous proteins to ADNP. The human ADNP2 contains 1131 amino acid residues with a molecular weight of 122.8 KDa. In silico analysis indicated that ortholgs to ADNP2 exist in different phyla, suggesting that ADNP2 might be evolutionary conserved. Here, we began to explore the molecular and functional characterization of ADNP2. Results showed that the mouse ADNP2 mRNA is ubiquitously expressed in distinct normal tissues with increased expression in the brain, particularly in the cerebral cortex. During development, a relatively high level of ADNP2 gene expression was found in the embryonic mouse brain and was sustained throughout embryogenesis and adulthood. An increase in the mRNA was detected in differentiated P19 neuronal/glial-like cells as compared with the non-differentiated cells. To gain insight into ADNP2 function, ADNP2-deficient cell lines were established by the RNA silencing (small interfering RNA) technology. ADNP2 deficiency significantly changed the toxicity induced by hydrogen peroxide in P19 embryonic carcinoma cells, similar to what would be predicted for ADNP deficiency. These findings represent an initial characterization of ADNP2 and suggest that this gene product may have an important function in brain by playing a role in cellular survival pathways.
Pupillary Movements During Acute and Chronic Fatigue A New Test for the Objective Evaluation of Tiredness (1963)

Spontaneous pupillary movements in darkness were recorded in \n1.healthy subjects of different ages when they were rested or fatigued, \n2.chronically tired subjects without known neurological defects, and \n3.patients with various neurological lesions. \n\nIn some of the experiments, local or systemic drugs were used. While the pupils are large and quiet in darkness when the subject is alert, they oscillate under the influence of tiredness. Waves of spontaneous pupillary contraction and dilation accompany periods of increasing sleepiness and spontaneous arousal until, at the moment immediately preceding sleep, the pupils become very small. The mechanism of these movements was analyzed and a simple test described which allows the objective determination of the degree of acute fatigue in a given subject at a given time. In the light of these results, the concepts of 'normal' and of 'pathologic' fatigue were discussed. \n\n
Dragonamides C and D, Linear Lipopeptides from the Marine Cyanobacterium Brown <i>Lyngbya polychroa</i> (2008)

Two new linear lipopeptides, 1 and 2, and a known compound, curacin D, have been isolated from a marine cyanobacterium, brown Lyngbya polychroa, collected from Hollywood Beach, Fort Lauderdale, Florida. Their planar structures were elucidated by 1D and 2D NMR techniques, and absolute configurations were assigned using chiral HPLC. The new compounds were assigned the trivial names dragonamide C (1) and dragonamide D (2), as their peptide moiety is related to previously reported dragonamides A and B.
MoLoc: On Distinguishing Fingerprint Twins (2013)

Indoor localization has enabled a great number of mobile and pervasive applications, attracting attentions from researchers worldwide. Most of current solutions rely on Received Signal Strength (RSS) of wireless signals as location fingerprint, to discriminate locations of interest. Fingerprint uniqueness with respect to locations is a basic requirement in these fingerprinting-based solutions. However, due to insufficient number of signal sources, temporal variations of wireless signals, and rich multipath effects, such requirement is not always met in complex indoor environments, which we refer to as fingerprint ambiguity. In this work, we explore the potential of leveraging user motion against fingerprint ambiguity. Our basic idea is that user motion patterns collected by built-in sensors of mobile phones add to the diversity built by RSS fingerprints. On this basis, we propose MoLoc, a motion-assisted localization scheme implemented on mobile phones. MoLoc can easily be integrated in existing localization systems by simply adding a motion database that is constructed automatically by crowdsourcing. We conducted experiments in a large office hall. The experiment results show that MoLoc doubles the localization accuracy achieved by the fingerprinting method, and limits the mean localization error to less than 1m.
Design of RFID based the Patient Management and Tracking System in hospital (2008)

The patient location information in managing for patient workflow will be worked efficiently within the hospital. We designed the Patient Management and Tracking System (PMTS) based on RFID with RSSI(Received Signal Strength Indication) method. This system is able to track the movement of patient in hospital, and manage the waiting-list of patients at a medical office. Therefore, we are sure that the PMTS will be useful for decreasing a duty of medical staff and increase a convenience of patients.
Pattern Similarity Analysis of Amino Acid Sequences for Peptide Emulsification (2004)

A new computer program for homology similarity search (HSS) was introduced. Application of the HSS to peptide sequences of short peptides with fewer 32 amino acid residues has explained the underlying mechanism of their emulsifying ability. It was found that certain regularity in the frequency of alternate polar/apolar cycle with high hydrophobic similarity density was required to obtain good emulsion. To supplement this required regularity, charge distribution, molecular flexibility, and a structural torsion caused by a proline residue might also play roles.
Detection of Carbapenemases by Real-Time PCR and Melt Curve Analysis on the BD Max System (2014)

We developed a multiplex SYBR green real-time PCR for the BD Max instrument (BD Diagnostics, Sparks, MD) to detect a panel of carbapenemases. The assay was evaluated with 152 consecutive isolates sent to the German National Reference Laboratory, and 65/65 of the carbapenemase-positive and 87/87 of the carbapenemase-negative strains were identified correctly.
Carbon Dioxide (2014)

This article contains sections titled: 1. Introduction 2. Physical Properties 3. Chemical Properties 4. Occurrence in Nature 4.1. Lithosphere 4.2. Atmosphere 4.3. Hydrosphere 4.4. Biosphere 4.4.1. Life Cycle 4.4.2. Radiocarbon Dating 5. Environmental Effects 6. Production 6.1. Carbon Dioxide from Ammonia and Hydrogen Plants (Process Gas CO2) 6.1.1. Potassium Carbonate Process 6.1.2. Ethanolamine Process 6.2. Carbon Dioxide from Flue Gases 6.3. Carbon Dioxide from Fermentation 6.4. Carbon Dioxide from Carbonates 6.5. Carbon Dioxide from Natural Sources 7. Purification of Carbon Dioxide before Liquefaction 8. Liquefaction of Carbon Dioxide 9. Production of Dry Ice 10. Quality Specifications and Analysis 11. Commercial Forms, Storage, and Distribution 11.1. Solid Carbon Dioxide 11.2. Liquid Carbon Dioxide 12. Uses 12.1. Uses of Gaseous Carbon Dioxide 12.2. Uses of Solid Carbon Dioxide 12.3. Uses of Liquid Carbon Dioxide 12.3.1. Use as an Inert Environment 12.3.2. Promoting the Growth of Plants 12.3.3. Heat Transfer Medium in Nuclear Power Stations 12.3.4. Refrigerant 12.3.5. Uses Based on the Solubility of Carbon Dioxide 12.3.6. Chemical Uses 12.3.7. Other Uses 12.4. Carbon Dioxide as Chemical Feedstock 12.4.1. Urea 12.4.2. Methanol 12.4.3. Methane 12.4.4. Salicylic Acid 12.4.5. Cyclic Carbonates 12.4.6. Acyclic Carbonates 12.4.7. Organic Acids 12.4.8. Carbamates 12.4.9. Alcohols and Aldehydes 12.4.10. Polymers from Carbon Dioxide 12.4.10.1. Polymers by Direct Conversion of Carbon Dioxide 12.4.10.2. Polymers and Polycondensates from Carbon Dioxide-Derived Components 12.4.11. Carbon Dioxide Mineralization 12.5. Future of Carbon Dioxide Utilization 13. Carbon Dioxide Capture 13.1. Considerations for Carbon Dioxide Capture 13.1.1. Carbon Dioxde Avoidance Costs 13.1.2. Carbon Capture-related Energy Demand 13.1.3. Carbon Dioxide Purity, Pressure, and Separation Degree 13.2. Carbon Dioxide Capture Routes 13.3. CCS-related Separation Technologies 13.3.1. Chemical Absorption 13.3.1.1. Chemical Absorbent Agents 13.3.1.2. Advantages and Disadvantages of Chemical Absorption 13.3.1.3. Impact of Process Design Parameters on the Thermal Energy Consumption 13.3.2. Physical Absorption 13.3.2.1. Process Description 13.3.2.2. Commercially Available Solvents 13.3.3. Cryogenic Air Separation 13.3.4. Adsorption 13.3.4.1. Inorganic Adsorbents 13.3.4.2. Organic and Organic–Inorganic Hybrid Adsorbents 13.3.4.3. Metal-Organic Frameworks (MOFs) 13.3.5. Chemical Looping Combustion and Gasification 13.3.6. Carbonate Looping 13.3.7. Gas Separation Membranes 13.4. Summary 14. Economic Aspects 15. Safety Precautions
TrkB Receptor Signalling: Implications in Neurodegenerative, Psychiatric and Proliferative Disorders (2013)

The Trk family of receptors play a wide variety of roles in physiological and disease processes in both neuronal and non-neuronal tissues. Amongst these the TrkB receptor in particular has attracted major attention due to its critical role in signalling for brain derived neurotrophic factor (BDNF), neurotrophin-3 (NT3) and neurotrophin-4 (NT4). TrkB signalling is indispensable for the survival, development and synaptic plasticity of several subtypes of neurons in the nervous system. Substantial evidence has emerged over the last decade about the involvement of aberrant TrkB signalling and its compromise in various neuropsychiatric and degenerative conditions. Unusual changes in TrkB signalling pathway have also been observed and implicated in a range of cancers. Variations in TrkB pathway have been observed in obesity and hyperphagia related disorders as well. Both BDNF and TrkB have been shown to play critical roles in the survival of retinal ganglion cells in the retina. The ability to specifically modulate TrkB signalling can be critical in various pathological scenarios associated with this pathway. In this review, we discuss the mechanisms underlying TrkB signalling, disease implications and explore plausible ameliorative or preventive approaches.
A Power Network Synthesis Method for Industrial Power Gating Designs (2007)

A sleep transistor P/G network synthesis method has been developed to address the requirements from industrial power-gating designs, where sleep transistors are custom designed with a fixed size and the optimal sleep transistor P/G network is achieved by simultaneously optimizing sleep transistor insertion and placement as well as the power network grids and wires for minimum area, maximum routeabillity with a given IR-drop target
Asthma Disease Management Program. (2000)

The Asthma Disease Management Program of the Kaiser Permanente Colorado (KPCO) Denver/Boulder Local Market began development in August 1995. Its pilot project was implemented in February 1997 with full implementation in August 1998. A very large team of participants contributed to the initial and ongoing success of this regionwide initiative. Table 1 identifies the complete list of project supporters and contributors.

Table 1

Kaiser Permanente Colorado Denver/Boulder Local Market Asthma Disease Management Program Project supporters/contributors
Role of Semiotics in Branding (2013)

This paper addresses the marketing concept of brand image from a semiotic perspective. A critical review of existing research from key authors in the brand semiotics literature is also done. By drawing on the structure and process of brand image it focuses on how semiotics can be helpful in increasing the effectiveness of various tools used for marketing. It also stresses the importance of semiotics as a vital tool used in positioning & repositioning of a brand thereby creating the desired brand image in the minds of the consumer.
Robin Williams Design Workshop (2000)

From the Publisher:
Learn design theory and practical know-how from the award-winning author/design team, Robin Williams and John Tollett

Robin Williams introduced design and typographic principles to legions of readers with her best-selling Non-Designer's book series. Now she and designer/co-author John Tollett take you to the next level of creative design with practical advice and lessons in composition, visual impact, and design challenges.

Presented in Robin and John's signature stylewriting that is so crystal clear, it's accessible to absolutely anyoneand illustrated with hundreds of full-color design examples, the ideas in this book tackle design theory, visual puns, and layout and graphics strategies for real-world projects. Developing designers will appreciate the author's imaginative approach and well-chosen examples.

Discover practical and effective design principles and conceptand how to apply them to virtually any project.
Learn why some designs are attention-getting and others are not.
Learn how to choose just the right lookcorporate or casual, classic or trendyfor specific types of projects, such as business cards, letterhead and envelopes, newsletters and brochures, logos, advertising, and more.
Test your design acumen by comparing before-and-after examples.
Find a wealth of inspiration for your own design projects.
Gain insight into the design process by studying the works of guest designers, who offer their personal commentary and insights.
Simplicial Activity Driven Model (2018)

Many complex systems find a convenient representation in terms of networks: structures made by pairwise interactions (links) of elements (nodes). For many biological and social systems, elementary interactions involve, however, more than two elements, and simplicial complexes are more adequate to describe such phenomena. Moreover, these interactions often change over time. Here, we propose a framework to model such an evolution: the simplicial activity driven model, in which the building block is a simplex of nodes representing a multiagent interaction. We show analytically and numerically that the use of simplicial structures leads to crucial structural differences with respect to the activity driven model, a paradigmatic temporal network model involving only binary interactions. It also impacts the outcome of paradigmatic processes modeling disease propagation or social contagion. In particular, fluctuations in the number of nodes involved in the interactions can affect the outcome of models of simple contagion processes, contrarily to what happens in the activity driven model.
SHOOT ORGANIZATION Genes Regulate Shoot Apical Meristem Organization and the Pattern of Leaf Primordium Initiation in Rice (2000)

Jun-Ichi Itoh, Hidemi Kitano, Makoto Matsuoka, Yasuo Nagato, SHOOT ORGANIZATION Genes Regulate Shoot Apical Meristem Organization and the Pattern of Leaf Primordium Initiation in Rice, The Plant Cell, Vol. 12, No. 11 (Nov., 2000), pp. 2161-2174
Design of a Surfactant Remediation Field Demonstration Based on Laboratory and Modeling Studies (1997)

Abstract Surfactant‐enhanced subsurface remediation is being evaluated as an innovative technology for expediting ground‐water remediation. This paper reports on laboratory and modeling studies conducted in preparation for a pilot‐scale field test of surfactant‐enhanced subsurface remediation. Laboratory batch and column studies evaluated the surfactant‐contaminant ground‐water interactions in an effort to properly design the field‐scale demonstration. A series of laboratory tracer tests and numerical simulations were completed to demonstrate the effectiveness of the hydraulic system (a vertical circulation well—VCW) for capturing injected solutions in a shallow, highly conductive, unconfined ground‐water formation. The results of these studies were then used to optimize the performance of the VCW system during the subsequent field‐scale demonstration study which utilized the VCW for injecting and extracting a surfactant solution. Information from the simulation studies, combined with the results of the batch and column tests, was crucial for procuring regulatory approval for the field demonstration, and successful design of the field‐scale demonstration.