gebhart/patrepeval huggingface dataset:
Tempol-mediated activation of latent iron regulatory protein activity prevents symptoms of neurodegenerative disease in IRP2 knockout mice (2008)

In mammals, two homologous cytosolic regulatory proteins, iron regulatory protein 1 (also known as IRP1 and Aco1) and iron regulatory protein 2 (also known as IRP2 and Ireb2), sense cytosolic iron levels and posttranscriptionally regulate iron metabolism genes, including transferrin receptor 1 (TfR1) and ferritin H and L subunits, by binding to iron-responsive elements (IREs) within target transcripts. Mice that lack IRP2 develop microcytic anemia and neurodegeneration associated with functional cellular iron depletion caused by low TfR1 and high ferritin expression. IRP1 knockout (IRP1(-/-)) animals do not significantly misregulate iron metabolism, partly because IRP1 is an iron-sulfur protein that functions mainly as a cytosolic aconitase in mammalian tissues and IRP2 activity increases to compensate for loss of the IRE binding form of IRP1. The neurodegenerative disease of IRP2(-/-) animals progresses slowly as the animals age. In this study, we fed IRP2(-/-) mice a diet supplemented with a stable nitroxide, Tempol, and showed that the progression of neuromuscular impairment was markedly attenuated. In cell lines derived from IRP2(-/-) animals, and in the cerebellum, brainstem, and forebrain of animals maintained on the Tempol diet, IRP1 was converted from a cytosolic aconitase to an IRE binding protein that stabilized the TfR1 transcript and repressed ferritin synthesis. We suggest that Tempol protected IRP2(-/-) mice by disassembling the cytosolic iron-sulfur cluster of IRP1 and activating IRE binding activity, which stabilized the TfR1 transcript, repressed ferritin synthesis, and partially restored normal cellular iron homeostasis in the brain.
Effects of Sodium L-Lactate and Sodium Racemic Lactate on Intraoperative Acid-Base Status (1992)

Lactated Ringer's solution is frequently used to avoid metabolic acidosis during fluid resuscitation. The standard lactated Ringer's solution contains racemic lactate, an equal mixture of the D- and L-stereoisomers. We investigated whether sodium L-lactate or sodium racemic lactate (DL-lactate) is more effective for increasing buffering capacity in body fluids. For the purpose of this comparison, Ringer's solutions containing no lactate, sodium L-lactate, or racemic lactate at a concentration of 84 mEq/L (three times more than the ordinary level) were infused in patients under general anesthesia during tympanoplasty. Although differences occurred among the three groups in blood concentrations of L-lactate, D-lactate, and the L-lactate/pyruvate ratio, no differences occurred between the two lactate groups in either bicarbonate ion concentration or base excess. The amount of buffering capacity increased significantly in both lactate groups, compared with preinfusion levels, and was more than the values in the nonlactated Ringer's solution group. We conclude that sodium racemic lactate is metabolized at nearly the same rate as that of sodium L-lactate.
Compact portable biosensor for arsenic detection in aqueous samples with <i>Escherichia coli</i> bioreporter cells (2014)

We present a compact portable biosensor to measure arsenic As(III) concentrations in water using Escherichia coli bioreporter cells. Escherichia coli expresses green fluorescent protein in a linearly dependent manner as a function of the arsenic concentration (between 0 and 100 μg/L). The device accommodates a small polydimethylsiloxane microfluidic chip that holds the agarose-encapsulated bacteria, and a complete optical illumination/collection/detection system for automated quantitative fluorescence measurements. The device is capable of sampling water autonomously, controlling the whole measurement, storing and transmitting data over GSM networks. We demonstrate highly reproducible measurements of arsenic in drinking water at 10 and 50 μg/L within 100 and 80 min, respectively.
Portable Low-cost MRI System based on Permanent Magnets/Magnet Arrays (2018)

Portable low-cost MRI systems have the potential to enable point-of-care and timely MRI diagnosis, and to make this imaging modality available to routine scans and to underdeveloped areas. With simplicity, no maintenance, no power consumption, and low cost, permanent magnets or arrays are attractive to use as a source of magnetic field to realize portability and low cost for a scanners. However, when taking the Fourier imaging approach and using linear gradient fields, homogeneous fields are required, thus either a bulky magnet is needed, or the imaging volume is too small to image an organ if the magnet is scaled down. Recently, with the progress on image reconstruction based on non-linear gradient field, field patterns without spatial-linearity can be used as spatial encoding magnetic fields to encode MRI signals for imaging. As a result, the requirements for the homogeneity of the field can be relaxed, which allows permanent magnets(arrays) with reduced sizes, reduced weight to image bigger volumes covering organs such as a head. It offers chances to construct a truly portable low-cost MRI scanner. For this exciting potential application, permanent magnets(arrays) have attracted increased attention. A magnet(array) is strongly associated with the imaging volume, reconstruction methods, and RF excitation and coils, etc. through field patterns and homogeneity. This paper offers a review on permanent magnets(arrays) of different kinds, especially those can be used for spatial encoding towards the development of portable and low-cost MRI systems. It is aimed to familiarize the readers with relevant knowledge, literature, and the latest updates of the development on permanent magnets for MRI. Perspectives on and challenges of using permanent magnets to supply a patterned magnetic field, without spatial-linearity nor high homogeneity, for reconstruction in a portable setup are discussed.
Applications of Self-assembled Monolayers in Biosensor (2004)

Properties of self-assembled monolayers and the applications in biosensor have been discussed in this paper.The easily and gradually changed chemical parameters of the components composing the monolayers get the biosensor are fully controllable.The high organization,homogeneity,stabilization and credibility make them very attractive for the construction of biosensor.
Succession of microorganisms in a plate-type air treatment biofilter during filtration of various volatile compounds (2014)

Changes in the number and species diversity of cultivable microorganisms in a newly developed plate-type biofilter during filtration of various volatile pollutants were studied. The novelty of the investigation is the monitoring of microorganism succession in different parts of biofilter plates with original packing material consisting of birch fibre and needle-punched non-woven fabric. It was shown that the largest number of fungi and yeasts develop on the top and middle, while bacteria develop on the bottom and middle parts of plates. The number of microorganisms depends on the origin of the pollutant, the pH and temperature inside the biofilter and the moisture of the porous plates. The statistically significant correlation between the number of microorganisms and inlet concentration of acetone was estimated, while ammonia showed a negative influence on yeast distribution. Paecilomyces variotii, Rhodotorula mucilaginosa and Bacillus subtilis were the most common organisms found during filtration of all examined volatiles; however, some differences of microbial communities in different parts of the biofilter plates and filtrated volatile compounds were obtained.
Real-time image data transposition method for high-speed digital inkjet printer (2014)

In general, the output bandwidth and printing speed of digital inkjet printer are limited as PC isn't capable of transposing large quantities of image data bit-by-bit in real-time. A new high-speed data processing system based on PowerPC processor and Virtex-5 series FPGA is proposed, and a high-efficiency transposition method is achieved by using FPGA.Three independent DDR2 controllers are instantiated inside FPGA and system output bandwidth is improved by the collaborative work among these controllers; bit-by-bit transposition unit is designed, image data is divided into small blocks and these blocks are efficiently read or written through burst transmission of DDR2 controllers. Performance testing results demonstrate that output bandwidth of FPGA is up to 327 Mb/s and printing speed of digital inkjet printer reaches 249 m2/h, which is much faster than PC processing system under the same conditions.
Noninnocence in Metal Complexes: A Dithiolene Dawn (2011)

Noninnocence in inorganic chemistry traces its roots back half a century to work that was done on metal complexes containing unsaturated dithiolate ligands. In a flurry of activity in the early 1960s by three different research groups, homoleptic bis and tris complexes of these ligands, which came to be known as dithiolenes, were synthesized, and their structural, electrochemical, spectroscopic, and magnetic properties were investigated. The complexes were notable for facile one-electron transfers and intense colors in solution, and conventional oxidation-state descriptions could not account for their electronic structures. The bis complexes were, in general, found to be square-planar, including the first examples of this geometry for paramagnetic complexes and different formal d(n) configurations. Several of the neutral and monoanionic tris complexes were found to have trigonal-prismatic coordination, the first time that this geometry had been observed in molecular metal complexes. Electronic structural calculations employing extended Hückel and other semiempirical computational methods revealed extensive ligand-metal mixing in the frontier orbitals of these systems, including the observation of structures in which filled metal-based orbitals were more stable than ligand-based orbitals of the same type, suggesting that the one-electron changes upon oxidation or reduction were occurring on the ligand rather than on the metal center. A summary of this early work is followed with a brief section on the current interpretations of these systems based on more advanced spectroscopic and computational methods. The take home message is that the early work did indeed provide a solid foundation for what was to follow in investigations of metal complexes containing redox-active ligands.
Binary-decision-diagram device (1995)

The device proposed here for future LSI's is based on a concept different from the Boolean equations usually used for representing digital functions. The unit function of this device is simple two-way switching and can be implemented utilizing various physical effects, such as optical switching, electron-wave modulation, and single-electron transport. Several possible device structures are presented, and a simulated result for a single-electron device is described.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A p-Multigrid Algorithm using Cubic Finite Elements for Efficient Deformation Simulation (2014)

We present a novel p-multigrid method for efficient simulation of co-rotational elasticity with higher-order finite elements. In contrast to other multigrid methods proposed for volumetric deformation, the resolution hierarchy is realized by varying polynomial degrees on a tetrahedral mesh. We demonstrate the efficiency of our approach and compare it to commonly used direct sparse solvers and preconditioned conjugate gradient methods. As the polynomial representation is defined w.r.t. the same mesh, the update of the matrix hierarchy necessary for co-rotational elasticity can be computed efficiently. We introduce the use of cubic finite elements for volumetric deformation and investigate different combinations of polynomial degrees for the hierarchy. We analyze the applicability of cubic finite elements for deformation simulation by comparing analytical results in a static scenario and demonstrate our algorithm in dynamic simulations with quadratic and cubic elements. Applying our method to quadratic and cubic finite elements results in speed up of up to a factor of 7 for solving the linear system.
Integrated roof wind energy system (2012)

Wind is an attractive renewable source of energy. Recent innovations in research and design have reduced to a few alternatives with limited impact on residential construction. Cost effective solutions have been found at larger scale, but storage and delivery of energy to the actual location it is used, remain a critical issue. The Integrated Roof Wind Energy System is designed to overcome the current issues of urban and larger scale renewable energy system. The system is built up by an axial array of skewed shaped funnels that make use of the Venturi Effect to accelerate the wind flow. This inventive use of shape and geometry leads to a converging air capturing inlet to create high wind mass flow and velocity toward a vertical-axis wind turbine in the top of the roof for generation of a relatively high amount of energy. The methods used in this overview of studies include an array of tools from analytical modelling, PIV wind tunnel testing, and CFD simulation studies. The results define the main design parameters for an efficient system, and show the potential for the generation of high amounts of renewable energy with a novel and effective system suited for the built environment.
Automatic Mode Switching of P/PI Speed Control for Industry Servo Drives Using Online Spectrum Analysis of Torque Command (2007)

Conventional proportional/proportional-integral (P/PI) speed controller for today's servo drives has to be manually tuned at the controller switching set point by trial and error, which may translate into drive system downtime and a subsequent loss of productivity. The adjustable drive performance is heavily dependent on the quality of expert knowledge. The performance becomes inadequate in applications where the operating conditions change in a wide range, i.e., tracking command, acceleration/deceleration time, and load disturbances. In this paper, we discuss the demands on simple controls/setups for industry servo drives. Analyzing the frequency content of the motor torque command, P/PI speed control mode switching is automatically performed with only a prior knowledge of the mechanical time constant. The dynamic performance of the proposed scheme assures a desired tracking response curve with minimal oscillation and settling time over the entire set of operating conditions. For a comprehensive comparison of conventional P/PI control scheme, we carried out extensive tests on an actual servo system.
REVIEWS (1978)

REVIEWS The Origins of Shakespeare. By EMRYS JONES Pp viii+290. Oxford Clarendon Press, 1977 £10 net T W CRAIK T W CRAIK Search for other works by this author on: Oxford Academic Google Scholar The Review of English Studies, Volume XXIX, Issue 114, May 1978, Pages 203–204, https://doi.org/10.1093/res/XXIX.114.203 Published: 01 May 1978
A host cell protein binds to a highly conserved sequence element (pac-2) within the cytomegalovirus a sequence (1989)

The human cytomegalovirus (CMV) a sequence has significant homology to two regions, pac-1 and pac-2, within the a sequence of herpes simplex virus type 1 (HSV-1). Both regions have been shown to be important cis-acting signals in HSV-1 genome maturation. We have demonstrated that a small fragment from within the CMV a sequence, containing the pac-1 and pac-2 motifs, carries all of the signals necessary for generation of genomic termini and for inversion. These observations indicated that the function of these highly conserved sequence motifs was similar in CMV and HSV-1. We have identified and partially purified a host cell protein with affinity for the sequence 5'-GGCGGCGGCGCATAAAA-3' within CMV pac-2. This partially purified protein has an apparent molecular weight of 89,000 under denaturing conditions and could be renatured after sodium dodecyl sulfate-polyacrylamide gel electrophoresis, suggesting that the capacity to bind DNA was the property of a single polypeptide chain. This activity was found in a wide variety of human cell lines, including those that are permissive as well as those that are nonpermissive for CMV growth, but not in cell lines from monkey, mouse, or drosophila origins. Our work implicates a host cell protein in a sequence function.
An integrated Shunt-LDO regulator for serial powered systems (2009)

In this paper, a new type of regulator is proposed for integration in ASICs used in serially powered systems. In the serial powering scheme, modules are placed in series and fed by a constant current source to reduce the IR drop on the cables which increases powering efficiency. At the module level the needed supply voltages are generated redundantly out of the current supply by several parallel operating ASICs with integrated regulation circuitry. A Shunt-LDO regulator has been developed to allow robust and redundant regulator operation and the generation of different supply voltages by parallel placed devices. The Shunt-LDO regulator scheme combines the capability of Low Drop-Out regulators to generate a constant supply voltage with the feature of shunt regulators to assure a constant current flow through the device. The Shunt-LDO regulator has been developed for application in the framework of next generation hybrid pixel detectors used in high energy physics experiments. This circuit has been prototyped in a 130 nm CMOS technology, capable of generating voltages in a range of 1.2-1.5 V with a minimum drop out voltage of 200 mV. The maximum shunt current is 500 mA with a load regulation factor corresponding to an output impedance of 30 mOmega.
An introduction to Docker for reproducible research, with examples from the R environment (2014)

As computational work becomes more and more integral to many aspects of scientific research, computational reproducibility has become an issue of increasing importance to computer systems researchers and domain scientists alike. Though computational reproducibility seems more straight forward than replicating physical experiments, the complex and rapidly changing nature of computer environments makes being able to reproduce and extend such work a serious challenge. In this paper, I explore common reasons that code developed for one research project cannot be successfully executed or extended by subsequent researchers. I review current approaches to these issues, including virtual machines and workflow systems, and their limitations. I then examine how the popular emerging technology Docker combines several areas from systems research - such as operating system virtualization, cross-platform portability, modular re-usable elements, versioning, and a `DevOps' philosophy, to address these challenges. I illustrate this with several examples of Docker use with a focus on the R statistical environment.
The murine lymphocyte receptor for IgE. II. Characterization of the multivalent nature of the B lymphocyte receptor for IgE. (1984)

The murine B lymphocyte Fc epsilon R is functionally multivalent. Radiolabeled rat IgE, when bound to the B cell Fc epsilon R will co-isolate with the Fc epsilon R on a rat IgE affinity column; examination of the affinity column eluate by SDS-PAGE reveals the component previously identified as the Fc epsilon R as well as E and L chains from IgE. At low levels of Fc epsilon R saturation, up to 30% of the Fc epsilon R bound IgE becomes bound to IgE-Affi-Gel. By using a biotin-avidin system, the coprecipitation of non-haptenated IgE with haptenated IgE was examined and the results suggest (but do not prove) a divalent receptor.
ENTEROTOXIN PRODUCTION BY SHIGELLA FLEXNERI 2A (1991)

FASANO, A.; GUANDALINI, S.; RUSSEL, R. G.; REA, B.; RAIMONDI, F.; LEVINE, M. M. Author Information
The Silastic Bladder Patch (1967)

No AccessJournal of Urology1 Dec 1967The Silastic Bladder Patch Louis Ashkar and Eugene Heller Louis AshkarLouis Ashkar Present address : 1855 Gaylord St., Denver, Colorado 80206. More articles by this author and Eugene HellerEugene Heller More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)62956-2AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail © 1967 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byKROPP B, CHENG E, LIN H and ZHANG Y (2018) RELIABLE AND REPRODUCIBLE BLADDER REGENERATION USING UNSEEDED DISTAL SMALL INTESTINAL SUBMUCOSAJournal of Urology, VOL. 172, NO. 4 Part 2, (1710-1713), Online publication date: 1-Oct-2004.SCHOELLER T, LILLE S, STENZL A, NINKOVIĆ M, PIZA H, OTTO A, RUSSELL R and WECHSELBERGER G (2018) BLADDER RECONSTRUCTION USING A PREVASCULARIZED CAPSULAR TISSUE SEEDED WITH UROTHELIAL CELLSJournal of Urology, VOL. 165, NO. 3, (980-985), Online publication date: 1-Mar-2001.Gleeson M and Griffith D (2018) The Use of Alloplastic Biomaterials in Bladder SubstitutionJournal of Urology, VOL. 148, NO. 5 Part 1, (1377-1382), Online publication date: 1-Nov-1992. Volume 98Issue 6December 1967Page: 679-683 Advertisement Copyright & Permissions© 1967 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Louis Ashkar Present address : 1855 Gaylord St., Denver, Colorado 80206. More articles by this author Eugene Heller More articles by this author Expand All Advertisement PDF downloadLoading ...
ChemInform Abstract: CATALYSIS BY HETEROPOLY COMPOUNDS. III. THE STRUCTURE AND PROPERTIES OF 12‐HETEROPOLYACIDS OF MOLYBDENUM AND TUNGSTEN (H3PMO12‐XWXO40) AND THEIR SALTS PERTINENT TO HETEROGENEOUS CATALYSIS (1982)

Abstract Die grundlegenden Eigenschaften von 12‐Heteropolysäuren des Mo und W, wie Struktur, Oberfläche, Acidität und Redoxmechanismus im festen Zustand werden im Hinblick auf die heterogene Katalyse untersucht.
Association Rule Discovery of Privacy Information (2007)

An association rule expresses the dependence of a set of attributes on other attributes. An apriori algorithm is one of the known techniques that is used in the identification of association rules. In this paper, we report on our experiments using this technique for privacy data identification and extraction from printed documents
Acoustic model-based matched filter processing for fading time-dispersive ocean channels: theory and experiment (1993)

It is shown that the performance of a conventional matched filter can be improved if the reference (replica) channel compensates for the distortion by the ocean medium. A model-based matched filter is generated by correlating the received signal with a reference channel that consists of the transmitted signal convolved with the impulse response of the medium. The channel impulse responses are predicted with a broadband propagation model using in situ sound speed measured data and archival bottom loss data. The relative performance of conventional and model-based matched filter processing is compared for large time-bandwidth-product linear-frequency-modulated signals propagating in a dispersive waveguide. From ducted propagation measurements conducted in an area west of Sardinia, the model-based matched filter localizes the depths of both the source and receiving array and the range between them. The peak signal-to-noise ratio for the model-based matched filter is always larger than that of the conventional filter.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Oxidative Stress Biomarkers and Antioxidant Protocols (2002)

The false color image on the cover was provided by Professor Susumu Terakawa and illustrates glucose-induced superoxide production in the islet
Pinacolization and reduction of aromatic carbonyls with aluminium–KOH (1996)

A simple and rapid procedure for the pinacolization of aromatic aldehydes and reduction of hindered ketones with inexpensive aluminium and KOH in methanol at ambient temperature is reported. The pinacolization and reduction are proposed to be proceeding via single electron transfer from aluminium.