gebhart/patrepeval huggingface dataset:
Ultrasonography in dentistry (2008)

This paper reviews diagnostic applications of ultrasound to dentistry, or dental ultrasonography, beginning with pioneering work of the 1960s up through present lines of research. Clinical, in vivo applications that are of direct interest to dental practice are reviewed here, including measurements of enamel thickness and periodontal pocket depth. In vitro research that involves destructive tooth preparation or procedures, such as sound speed measurements or scanning acoustic microscopy, also are included. Although dental ultrasonography has been studied for over 40 years, most methods are not quite ready for routine clinical use, and there remains much opportunity for diagnostic ultrasonography to significantly impact the practice of dentistry.
Biofilms of Pathogenic Nontuberculous Mycobacteria Targeted by New Therapeutic Approaches (2015)

Microbial infections of the cornea are potentially devastating and can result in permanent visual loss or require vision-rescuing surgery. In recent years, there has been an increasing number of reports on nontuberculous mycobacterial infections of the cornea. Challenges to the management of nontuberculous mycobacterial keratitis include delayed laboratory detection, low index of clinical suspicion, poor drug penetration, slow response to therapy, and prolonged use of antibiotic combinations. The ability of nontuberculous mycobacteria to evade the host immune response and the ability to adhere and to form biofilms on biological and synthetic substrates contribute to the issue. Therefore, there is an urgent need for new antimicrobial compounds that can overcome these problems. In this study, we evaluated the biofilm architectures for Mycobacterium chelonae and Mycobacterium fortuitum in dynamic flow cell chamber and 8-well chamber slide models. Our results showed that mycobacterial biofilms were quite resistant to conventional antibiotics. However, DNase treatment could be used to overcome biofilm resistance. Moreover, we successfully evaluated a new antimicrobial compound (AM-228) that was effective not only for planktonic mycobacterial cells but also for biofilm treatment and was compared favorably with the most successful "fourth-generation" fluoroquinolone, gatifloxacin. Finally, a new treatment strategy emerged: a combination of DNase with an antibiotic was more effective than an antibiotic alone.
Synchronization of Nonlinear Oscillators in an LTI Electrical Power Network (2014)

Sufficient conditions are derived for the global asymptotic synchronization of a class of identical nonlinear oscillators coupled through a linear time-invariant network. In particular, we focus on systems where oscillators are connected to a common node through identical branch impedances. For such networks, it is shown that the synchronization condition is independent of the number of oscillators and the value of the load impedance connected to the common node. Theoretical findings are then leveraged to control a system of parallel single-phase voltage source inverters serving an impedance load in an islanded microgrid application. The ensuing paradigm: i) does not necessitate communication between inverters, ii) is independent of system load, and iii) facilitates a modular design approach because the synchronization condition is independent of the number of oscillators. We present both simulation and experimental case studies to validate the analytical results and demonstrate the proposed application.
Progress in defining a standard for file-level metadata (1996)

In the following narrative, metadata required to locate a file on tape or collection of tapes will be referred to as file-level metadata. This paper discribes the rationale for and the history of the effort to define a standard for this metadata.
ChemInform Abstract: DIMERIC NAPHTHOQUINONES, XIV. INTERMEDIATES OF THE CYCLOTRIMERIZATION OF NAPHTHOQUINONE: SYNTHESIS OF HYDROXYHEPTA(2.2.2)STARPHENEQUINONES (1985)

Abstract Bei der Cyclotrimerisierung von Naphthochinon (I) zum Trichinon (II) werden die nicht direkt faßbaren Zwischenstufen (IVa) und (Va) durchlaufen.
An Overview of Lidar Imaging Systems for Autonomous Vehicles (2019)

Lidar imaging systems are one of the hottest topics in the optronics industry. The need to sense the surroundings of every autonomous vehicle has pushed forward a race dedicated to deciding the final solution to be implemented. However, the diversity of state-of-the-art approaches to the solution brings a large uncertainty on the decision of the dominant final solution. Furthermore, the performance data of each approach often arise from different manufacturers and developers, which usually have some interest in the dispute. Within this paper, we intend to overcome the situation by providing an introductory, neutral overview of the technology linked to lidar imaging systems for autonomous vehicles, and its current state of development. We start with the main single-point measurement principles utilized, which then are combined with different imaging strategies, also described in the paper. An overview of the features of the light sources and photodetectors specific to lidar imaging systems most frequently used in practice is also presented. Finally, a brief section on pending issues for lidar development in autonomous vehicles has been included, in order to present some of the problems which still need to be solved before implementation may be considered as final. The reader is provided with a detailed bibliography containing both relevant books and state-of-the-art papers for further progress in the subject.
New arrangements, new scrutiny. The IRS reconsiders hospital-physician relationships at tax-exempt facilities. (1992)

The pressure to maintain adequate operating margins has forced many not-for-profit hospitals to adopt more overtly competitive behavior than they have in the past. However, in struggling to remain economically viable, these facilities should carefully avoid actions that would threaten their tax-exempt status. Not-for-profit facilities should be particularly careful that their arrangements with physicians, which often appear designed to increase referrals, do not violate the criteria according to which the Internal Revenue Code extends tax exemption to charitable organizations. Section 501(c)(3) of the code exempts organizations "no part of the net earnings of which inures to the benefit of any private shareholder or individual." According to this provision, "insiders" (i.e., those with a personal interest in or opportunity to influence organization activities from the inside) are entitled to no more than reasonable payment for their goods or services. The Internal Revenue Service (IRS) takes the position that, as employees or individuals having a close professional working relationship with a hospital, physicians are insiders. Thus a hospital that pays physicians what the IRS judges to be more than fair market value for services (or charges physicians less than fair market value for office rental) may find its exemption in jeopardy. If not-for-profit hospitals want to maintain their tax-exempt status, they must be certain the arrangements they enter into with physicians truly further their exempt purpose: to promote the health of the community.
A Novel LRSPP Based Refractive Index Sensor (2006)

A novel three-layer sensor based on LRSPP is proposed for detecting the refractive index changes, especially in the biosensor field. We find that the loss and electromagnetic field size of LRSPP are sensitive to the refractive index of detection substance. By measuring the output power or (and) field size of LRSPP, we can detect the refractive index changes of detection substance. LRSPP field size is a new parameter here for refractive index change detection and may lead to a much higher sensitivity compared to current SPP biosensors.
Enantioselective Total Synthesis of the Unnatural and the Natural Stereoisomers of Vittatalactone (2010)

The striped cucumber beetle, Acalymma vittatum, is a cause of major damage to cucurbit crops in North America. To develop an environmentally benign plant protection strategy, recent research has focused on identifying sex pheromones of the cucumber beetle. In this context, we developed the asymmetric total synthesis of the aggregation pheromone of A. vittatum, Vittatalactone, to determine its absolute configuration and to further examine the pheromone response in field studies. The synthesis features an enzyme-catalyzed approach toward the deoxypropionate structural motif. A preformed organocopper reagent could then be coupled in an enantioselective o-DPPB-directed allylic substitution with a functionalized o-DPPB-ester. By means of this efficient transformation, Vittatalactone could be obtained following a highly convergent synthetic process.
Radical total gastrectomy plus D2 dissection for gastric cancer (2013)

A 78-year-old male was presented in our hospital. His preoperative CT and B-mode ultrasound showed no liver or lung metastasis. Enlarged lymph nodes (1-2 cm in diameter) were found around the stomach and near the common bile duct. These masses invaded the serous layer. However, no enlarged lymph node was detected after peritoneum or near abdominal aorta. Pre-operative chemotherapy was not feasible for such an elderly patient. Radical surgery was then scheduled.
Induction of dorsal and ventral mesoderm by ectopically expressed <i>Xenopus</i> basic fibroblast growth factor (1992)

ABSTRACT Peptide growth factors from the fibroblast growth factor (FGF) and transforming growth factor-β families are likely regulators of mesoderm formation in the early Xenopus embryo. Although basic FGF is found in the Xenopus embryo at the correct time and at sufficient concentrations to suggest that it is the FGF-type inducer, the lack of a secretory signal sequence in the basic FGF peptide has raised questions as to its role in the inductive process. We show here that Xenopus basic FGF can ectopically induce mesoderm when translated from injected synthetic RNA within the cells of a Xenopus embryo. Basic FGF produced in this manner is able to induce the formation of both dorsal and ventral mesoderm with the type of mesoderm formed dependent on the inherent dorsal-ventral polarity of the animal hemisphere. Surprisingly, although Xenopus basic FGF produced from the injected mRNA has a potent mesodermalizing effect on animal hemisphere cells, virtually no phenotypic effect is observed with intact embryos. These results suggest that the role of Xenopus basic FGF is to specify the size of the marginal zone, and synergistically with a dorsally localized prepatterning signal, to initially establish the dorsal-ventral axis of the mesoderm.
The endocannabinoid system in bull sperm and bovine oviductal epithelium: role of anandamide in sperm–oviduct interaction (2008)

Anandamide binds to cannabinoid receptors and plays several central and peripheral functions. The aim of this work was to study the possible role for this endocannabinoid in controlling sperm-oviduct interaction in mammals. We observed that bull sperm and bovine oviductal epithelial cells express cannabinoid receptors, CB1 and CB2, and fatty acid amide hydrolase, the enzyme that controls intracellular anandamide levels. A quantitative assay to determine whether anandamide was involved in bovine sperm-oviduct interaction was developed. R(+)-methanandamide, a non-hydrolysable anandamide analog, inhibited sperm binding to and induced sperm release from oviductal epithelia. Selective CB1 antagonists (SR141716A or AM251) completely blocked R(+)-methanandamide effects. However, SR144528, a selective CB2 antagonist, did not exert any effect, indicating that only CB1 was involved in R(+)-methanandamide effect. This effect was not caused by inhibition of the sperm progressive motility or by induction of the acrosome reaction. Overall, our findings indicate for the first time that the endocannabinoid system is present in bovine sperm and oviductal epithelium and that anandamide modulates the sperm-oviduct interaction, by inhibition of sperm binding and induction of sperm release from oviductal epithelial cells, probably by activating CB1 receptors.
Fighting malicious code (2014)

Despite many years of research and significant commercial investment, the malware problem is far from being solved (or even reasonably well contained). Every week, the mainstream press publishes articles that describe yet another incident where millions of credit cards were leaked, a large company discloses that adversaries had remote access to its corporate secrets for years, and we discover a new botnet with tens of thousands of compromised machines. Clearly, this situation is not acceptable, but why isn't it getting any better?
Comparison of the Effectiveness of Two Pelvic Stabilization Systems on Pelvic Movement During Maximal Isometric Trunk Extension and Flexion Muscle Contractions (1987)

The purpose of this study was to compare the effectiveness of two pelvic fixation systems to limit pelvic movement during isometric trunk extension and flexion muscle strength testing. We developed a prototypal pelvic fixation system and compared it with a pelvic strap stabilization system. The prototypal pelvic fixation system consisted of fixation of the anterior superior iliac spines and sacrum, and the pelvic strap stabilization system consisted of a strap across the anterior superior iliac spines and a posterior pad. Small, but statistically significant, pelvic position changes occurred during isometric trunk extension and flexion muscle strength testing with the two stabilization systems. The pelvic angle changes were greater in extension than in flexion and greater when only the pelvic strap stabilization system rather than the prototypal pelvic fixation system was used. Our findings indicate that a more extensive prototypal pelvic fixation system minimizes pelvic movement to a greater extent during isometric trunk extension and flexion muscle contractions compared with the strap stabilization system.
Ciliated cell adenocarcinoma of the endometrium diagnosed by endometrial brush cytology and confirmed by hysterectomy; A case report detailing a highly efficient cytology collection and processing technique (1997)

A case of ciliated endometrioid adenocarcinoma of the endometrium, diagnosed by endometrial brush cytology and confirmed by histology, is reported. Features are those of outspoken endometrial adenocarcinoma presenting in a postmenopausal woman with abnormal uterine bleeding. Distinctive characteristics include ciliated neoplastic cells, intracytoplasmic ciliary cysts, complex epithelial stratification, and muscular invasion by malignant ciliated cells in the matched hysterectomy specimen. This report illustrates the merit of linking an easy-to-use liquid fixative with brush-sampling of the endometrium.
Tinnitus: Surgical Treatment (1981)

Surgical treatment of tinnitus includes destructive procedures, neurectomies, stapedectomies and tympanosympathectomies. Translabyrinthine procedures for the removal of acoustic neuromas and sectioning of the eighth nerve to eliminate vertigo are analogous to cutting the eighth nerve as a surgical intervention for tinnitus. After surgical removal of acoustic tumours with excision of the auditory nerve in 414 patients, only 40% reported improvement in their tinnitus. Of 68 patients undergoing translabyrinthine eighth nerve section, 60 (80%) had tinnitus preoperatively. Improvement occurred in 45%, while 55% reported the condition to be the same or worse. In patients undergoing middle cranial fossa section of the vestibular nerve for vertigo or dizziness, most reported the tinnitus to be the same but a significant number felt that it was worse. Stapedectomy improves hearing in most patients but improves the symptom of tinnitus in only about half of the patients. Cochlear implant patients report an improvement in their tinnitus with use of the stimulator and implant. Implant procedures might therefore be used in patients who suffer from severe tinnitus. Surgical management of tinnitus, although successful in some cases, does not provide a valid and reliable mode of treatment for subjective tinnitus.
Kinematic Analysis of Cell Division in Leaves of Mono- and Dicotyledonous Species: A Basis for Understanding Growth and Developing Refined Molecular Sampling Strategies (2012)

The cellular level processes cell division and cell expansion form a crucial level linking regulatory processes at the molecular level to whole plant growth rates and organ size and shape. With the rapid progress in molecular profiling, quantification of cellular activities becomes increasingly important to determine sampling strategies that are most informative to understand the molecular basis for organ and plant level phenotypes. Inversely, to understand phenotypes caused by genetic or environmental perturbations it is crucial to know how the cell division and expansion parameters are affected spatially and temporally. Kinematic analyses provide a powerful and rigorous mathematical framework to quantify cell division and cell expansion rates. In dicotyledonous leaves, these processes are primarily changing over time, resulting in division, expansion, and mature phases of development. Monocotyledonous leaves have a persistent spatial gradient, with an intercalary meristem where division takes place, an expansion zone, and a mature part of the leaf. Here we describe in detail how to perform kinematic analyses in leaves of the model species Arabidopsis thaliana and in the leaves of the monocotyledonous crop species Zea mays. These methods can readily be used and adapted to suit other species using relatively standard equipment present in most laboratories. Importantly, the obtained results can be used to design sampling techniques for proliferating, expanding and mature cells.
A Dynamically Biased Multiband 2G/3G/4G Cellular Transmitter in 28 nm CMOS (2016)

We present a highly configurable, low-power, low-area, low-EVM, SAW-less transmitter (TX) architecture that is based on a dynamically biased power mixer. All FDD/TDD bands from 0.7 to 2.7 GHz for 4G LTE Rel-11 and 3G HSPA+ are supported in addition to 2G quad bands. The power-mixer bias current is dynamically adjusted based on the instantaneous baseband signal swing using a fully-differential hybrid full-wave rectifier/envelope-detector circuit. Dynamic biasing leads to greater than 50% current savings when compared to fixed-biasing while providing a higher output power with better linearity. Implemented in 28 nm CMOS technology, the TX shows better than -157 dBc/Hz RX-band noise emission and -41 dBc ACLR for output powers up-to +4 dBm across all 3G/4G bands, while demonstrating above 80 dB of gain control range. In addition, the TX can be configured to provide better than -65 dBc CIM3, allowing it to meet stringent spurious emission specifications when transmitting 1 RB 4G LTE signals in B13/B26/B1.
Self-renewing canine oligodendroglial progenitor expanded as oligospheres (1998)

We have previously shown that oligodendroglial progenitors (OP) can be generated from multipotent rat neural precursor cells. We now report the generation of a homogeneous culture of canine OP from neural precursor cells. In non-adherent cultures, homogeneous OP cultures were obtained in 6-8 weeks of treatment with B104 cell conditioned medium (B104CM). In adherent cultures where astrocytes grew as a layer of substrate, colonies of OP invariably appeared at 10-14 days in vitro (DIV) and the colonies were expanded as free-floating spheres (oligospheres), in the presence of B104CM, suggesting that astrocytes facilitate the generation of canine OP. The oligosphere cells were characterized by self-renewal in the presence of B104CM and by terminal differentiation into oligodendrocytes after withdrawal of B104CM. Transplantation studies indicated that the extensively expanded oligosphere cells retained myelination capacity. The oligospheres thus provide a valuable source for experimental cell therapy studies.
Development of Copper-Carbon Fiber Composite for Electrodes of Power Semiconductor Devices (1983)

In power semiconductor devices, a supporting electrode made of materials such as molybdenum or tungsten is inserted between a silicon wafer and a copper block. The electrode functions as a means for alleviating thermal stress acting on the wafer, as well as a means for conducting electric current. A copper--carbon fiber composite suitable to be the supporting electrode has been developed. The properties of the composite structure are expected to vary depending on the orientation of the fibers. In the case of disk-shaped electrodes usually employed for power devices, the thermal expansion coefficient of the composite has to be isotropic at least on the surface contacting the silicon wafer. That is, two-dimensional isotropy is required. For this purpose, carbon fibers were embedded in a copper matrix in either a weaving, bidirectional, or spiral arrangement. The properties of these composites were adjusted within a certain range by changing the volume, kind, and/or arrangement of carbon fibers. This new composite was applied to a new resin molded diode. The properties of this new diode compared favorably with those of conventional diodes using molybdenum or tungsten electrodes. It is concluded that the new composite electrode with carbon fibers satisfies all of the major requirements for the electrodes in power semiconductor devices.
Monoclonal antibodies neutralizing human leukocyte acid- and thermolabile interferon alpha. (1989)

Using a high titred human leukocyte IFN alpha preparation which contained both acid- and thermolabile (AL-IFN alpha) and acid- and thermostable IFN alpha species in 9:1 proportion for immunization of BALB/c mice, five hybridomas secreting monoclonal antibodies that reacted with AL-IFN alpha were obtained. In antiviral and antiproliferative tests on HL-60 cells, their products showed high degree of specificity for AL-IFN alpha. The results suggest that both the "normal" leukocyte AL-IFN alpha and the IFN alpha found in sera of autoimmune and other chronic patients might belong to the same subtype of IFN alpha.
The effect of autocorrelation length on the real area of contact and friction behavior of rough surfaces (2005)

Autocorrelation length (ACL) is a surface roughness parameter that provides spatial information of surface topography that is not included in amplitude parameters such as root-mean-square roughness. This paper presents a relationship between ACL and the friction behavior of a rough surface. The influence of ACL on the peak distribution of a profile is studied based on Whitehouse and Archard’s classical analysis [Whitehouse and ArchardProc. R. Soc. London, Ser. A 316, 97 (1970)] and their results are extended to compare profiles from different surfaces. The probability density function of peaks and the mean peak height of a profile are given as functions of its ACL. These results are used to estimate the number of contact points when a rough surface comes into contact with a flat surface, and it is shown that the larger the ACL of the rough surface, the less the number of contact points. Based on Hertzian contact mechanics, it is shown that the real area of contact increases with increasing of number of contact points. Since adhesive friction force is proportional to the real area of contact, this suggests that the adhesive friction behavior of a surface will be inversely proportional to its ACL. Results from microscale friction experiments on polished and etched silicon surfaces are presented to verify the analysis.