gebhart/patrepeval huggingface dataset:
High Density Mapping of Atrial Fibrillation During Vagal Nerve Stimulation in the Canine Heart: Restudying the Moe Hypothesis (2012)

In contrast to the prediction of the multiple wavelet hypothesis, during AF in the Moe model, multiple foci drove the atria, producing and maintaining AF. Reentry played little, if any, role.
A systematic method for functional unit power estimation in microprocessors (2006)

We present a new method for mathematically estimating the active unit power of functional units in modern microprocessors such as the Pentium 4 family. Our method leverages the phasic behavior in power consumption of programs, and captures as many power phases as possible to form a linear system of equations such that the functional unit power can be solved. Our experiment results on a real Pentium 4 processor show that power estimations attained as such agree with the measured power very well, with deviations less than 5% only.
Synthesis of a Library of Fucosylated Glycoclusters and Determination of their Binding toward Pseudomonas aeruginosa Lectin B (PA-IIL) Using a DNA-Based Carbohydrate Microarray (2012)

Pseudomonas aeruginosa (PA) is a Gram negative opportunistic pathogen and is the major pathogen encounter in the cystic fibrosis (CF) lung airways. It often leads to chronic respiratory infection despite aggressive antibiotic therapy due to the emergence of resistant strains and to the formation of biofilm. The lectin PA-IIL (LecB) is a fucose-specific lectin from PA suspected to be involved in host recognition/adhesion and in biofilm formation. Thus, it can be foreseen as a potential therapeutic target. Herein, 16 fucosylated glycoclusters with antenna-like, linear, or crown-like spatial arrangements were synthesized using a combination of DNA solid-phase synthesis and alkyne azide 1,3-dipolar cycloaddition (CuAAC). Their binding properties toward PA-IIL were then evaluated based on DNA directed immobilization (DDI) carbohydrate microarray. Our results suggested that the antenna-like scaffold was preferred to linear or crown-like glycoclusters. Among the crown-like carbohydrate centered fucosylated glycoclusters, mannose-based core was better than glucose- and galactose-based ones. The influence of the linker arm was also evaluated, and long linkers between fucoses and the core led to a slight better binding than the short ones.
On motion planning for narrow-clearance assemblies using virtual manikins (2018)

Digital Human Modeling (DHM) is an important tool to improve assembly ergonomics and thereby also productivity and product quality. State-of-art DHM tools can simulate challenging assembly operations by solving inverse kinematic problems so that the positions/orientations of the hands/feet of a manikin match some manually-specified targets. However, it is still difficult and time-consuming for a simulation engineer to perform an assembly with narrow insertion clearances by manually setting hand targets. We present a novel and highly automated approach that explores the 4D space (position of a fingertip plus pronation/supination of the arm) around an initial path for a sphere.
DiaGen: A Generator for Diagram Editors Based on a Hypergraph Model. (1995)

Diagrams (e.g., trees for hierarchical structures, or graphs for finite state machines) are often needed as part of advanced user interfaces, and are frequently specific to a user&apos;s application. The implementation of editors for diagrams should be supported by a tool and based on a formal model. This paper gives an overview of DiaGen, our generator for diagram editors. An editor for a certain kind of diagrams is generated from a specification, which includes a hypergraph grammar to describe the structure of diagrams. The user of a diagram editor does not have to be concerned with the grammar, but can manipulate diagrams very conveniently by direct manipulation. 1 Introduction An easily comprehensible representation of complex structures is gaining importance for the users of information systems or CASE tools. A significant and increasing share of the effort for implementing these systems goes into the user interface. Common interface builders for Graphical User Interfaces (GUIs) main...
Biomedical Potentials of Crown Ethers: Prospective Antitumor Agents (2008)

Crown ethers are of enormous interest and importance in chemistry, biochemistry, materials science, catalysis, separation, transport and encapsulated processes, as well as in the design and synthesis of various synthetic systems with specific properties, diverse capabilities, and programmable functions. Classical crown ethers are macrocyclic polyethers that contain 3-20 oxygen atoms separated from each other by two or more carbon atoms. They are exceptionally versatile in selectively binding a range of metal ions and a variety of organic neutral and ionic species. Crown ethers are currently being studied and used in a variety of applications beyond their traditional place in chemistry. This review presents additional applications and the ever-increasing biomedical potentials of these intriguing compounds, with particular emphasis on the prospects of their relevance as anticancer agents. We believe that further research in this direction should be encouraged, as crown compounds could either induce toxicities that are different from those of conventional antitumor drugs, or complement drugs in current use, thereby providing a valuable adjunct to therapy.
Self-Assembly of Lithographically Patterned Nanoparticles (2009)

The construction of three-dimensional (3D) objects, with any desired surface patterns, is both critical to and easily achieved in macroscale science and engineering. However, on the nanoscale, 3D fabrication is limited to particles with only very limited surface patterning. Here, we demonstrate a self-assembly strategy that harnesses the strengths of well-established 2D nanoscale patterning techniques and additionally enables the construction of stable 3D polyhedral nanoparticles. As a proof of the concept, we self-assembled cubic particles with sizes as small as 100 nm and with specific and lithographically defined surface patterns.
Optimization of Takeoffs on Unbalanced Fields using Takeoff Performance Tool (2016)

Unbalanced field length exists when ASDA and TODA are not equal. Airport authority may add less expensive substitutes to runway full-strength pavement in the form of stopways and/or clearways to basic TORA to increase operational takeoff weights. Here developed Takeoff Performance Tool is a physics-based total-energy model used to simulate FAR/CS 25 regulated airplane takeoffs. Any aircraft, runway, and environmental conditions can be simulated, while complying with the applicable regulations and maximizing performance takeoff weights. The mathematical model was translated into Matlab, Fortran 95/2003/2008, Basic, and MS Excel computer codes. All existing FAR/CS 25 takeoff regulations are implemented. Average forces are calculated for takeoff accelerate-go and accelerate-stop scenarios with all-engine-operating and one-engine-inoperative conditions. Special attention was paid to simulating increase in FLLTOW as the clearways and/or stopways are added in varying ratios. From the limited parametric study it appears that clearway-to-stopway ratio addition of 4:1 gives good overall performance increase while keeping decision/action speed constant. The critical clearway length exists for which both TORA and TODA are equally limiting. Corrections for effective runway slopes and wind were derived. The presented takeoff performance model provides a platform for more in-depth optimization studies and economic analysis of runway-airplane-engines synergy.
Optimal realizable filters and the minimum Euclidean distance principle (1993)

Minimizing a Euclidean distance in the complex plane optimizes a wide class of correlation metrics for filters implemented on realistic devices. The algorithm searches over no more than two real scalars (gain and phase). It unifies a variety of previous solutions for special cases (e.g., a maximum signal-to-noise ratio with colored noise and a real filter and a maximum correlation intensity with no noise and a coupled filter). It extends optimal partial information filter theory to arbitrary spatial light modulators (fully complex, coupled, discrete, finite contrast ratio, and so forth), additive input noise (white or colored), spatially nonuniform filter modulators, and additive correlation detection noise (including signaldependent noise). An appendix summarizes the algorithm as it is implemented in available computer code.
Differential effects of sorafenib on liver versus tumor fibrosis mediated by stromal-derived factor 1 alpha/C-X-C receptor type 4 axis and myeloid differentiation antigen–positive myeloid cell infiltration in mice (2013)

Blocking SDF-1α/CXCR4 or Gr-1(+) myeloid cell infiltration may reduce hypoxia-mediated HCC desmoplasia and increase the efficacy of sorafenib treatment.
An allosteric transition trapped in an intermediate state of a new kinesin–inhibitor complex (2009)

Human kinesin Eg5 plays an essential role in mitosis by separating duplicated centrosomes and establishing the bipolar spindle. Eg5 is an interesting drug target for the development of cancer chemotherapy, with seven inhibitors already in clinical trials. In the present paper, we report the crystal structure of the Eg5 motor domain complexed with a potent antimitotic inhibitor STLC (S-trityl-L-cysteine) to 2.0 A (1 A=0.1 nm) resolution. The Eg5-STLC complex crystallizes in space group P3(2) with three molecules per asymmetric unit. Two of the molecules reveal the final inhibitor-bound state of Eg5, whereby loop L5 has swung downwards to close the inhibitor-binding pocket, helix alpha4 has rotated by approx. 15 degrees and the neck-linker has adopted a docked conformation. The third molecule, however, revealed an unprecedented intermediate state, whereby local changes at the inhibitor-binding pocket have not propagated to structural changes at the switch II cluster and neck-linker. This provides structural evidence for the sequence of drug-induced conformational changes.
Myelin‐associated glycoprotein inhibits neurite/axon growth and causes growth cone collapse (1996)

We have previously shown that myelin-associated glycoprotein (MAG) inhibits neurite growth from a neuronal cell line. In this study we show that 60% of axonal growth cones of postnatal day 1 hippocampal neurons collapsed when they encountered polystyrene beads coated with recombinant MAG (rMAG). Such collapse was not observed with denatured rMAG. Neurite growth from rat embryonic hippocampal and neonatal cerebellar neurons was also inhibited about 80% on tissue culture substrates coated with rMAG. To investigate further the inhibitory activity of MAG in myelin, we purified myelin from MAG-deficient mice and separated octylglucoside extracts of myelin by diethylaminoethyl (DEAE) ion-exchange chromatography. Although there was no significant difference in neurite growth on myelin purified from MAG-/- and MAG+/+ mice, differences were observed in the fractionated material. The major inhibitory peak that is associated with MAG in normal mice was significantly reduced in MAG-deficient mice. These results suggest that although MAG contributes significantly to axon growth inhibition associated with myelin, its lack in MAG-deficient mice is masked by other non-MAG inhibitors. Axon regeneration in these mice was also examined after thoracic lesions of the corticospinal tracts. A very small number of anterogradely labeled axons extended up to 13.2 mm past the lesion in MAG-/- mice. Although there is some enhancement of axon generation, the poor growth after spinal cord injury in MAG-/- mice may be due to the presence of other non-MAG inhibitors. The in vitro studies, however, provide the first evidence that MAG modulates growth cone behavior and inhibits neurite growth by causing growth cone collapse. © 1996 Wiley-Liss, Inc.
Damped multichannel singular spectrum analysis for 3D random noise attenuation (2015)

Summary Multichannel singular spectrum analysis (MSSA) is an effective algorithm for random noise attenuation in seismic data, which decomposes the vector space of the Hankel matrix of the noisy signal into a signal subspace and a noise subspace by the truncated singular value decomposition (TSVD). However, this signal subspace actually still contains residual noise. In this abstract, we derive a new formula of low-rank reduction, which is more powerful in distinguishing between signal and noise compared with traditional TSVD. By introducing a trim factor for damping the singular values in traditional MSSA, we propose a new algorithm for random noise attenuation. The proposed modified MSSA is named as the damped MSSA. Application of the damped MSSA algorithm on synthetic and field seismic data demonstrates a superior performance compared with the conventional MSSA algorithm and the 2D median filtering.
Cytokine Regulation of Periportal Fibrosis in Humans Infected with <i>Schistosoma mansoni</i>: IFN-γ Is Associated with Protection Against Fibrosis and TNF-α with Aggravation of Disease (2002)

Hepatic periportal fibrosis, which affects 5-10% of subjects infected by Schistosoma mansoni, is caused by the T cell-dependent granuloma that develop around schistosome eggs. Experimental models of infection have shown that granuloma and fibrosis are tightly regulated by cytokines. However, it is unknown why advanced periportal fibrosis occurs only in certain subjects. The goal of the present study was to evaluate the cytokine response of S. mansoni-infected subjects with advanced liver disease in an attempt to relate susceptibility to periportal fibrosis with an abnormal production of cytokines that regulate granuloma and fibrosis. Fibrosis was evaluated by ultrasound on 795 inhabitants of a Sudanese village in which S. mansoni is endemic: advanced periportal fibrosis was observed in 12% of the population; 35% of the affected subjects exhibited signs of portal hypertension. Age (odds ratio (OR), 11.5), gender (OR, 4.2), and infection levels (OR, 2.2) were significantly (p < or = 0.01) associated with hepatic fibrosis. Cytokines produced by egg-stimulated blood mononuclear cells from 99 subjects were measured (75 with no or mild fibrosis; 24 subjects with advanced fibrosis). Multivariate analysis of cytokine levels showed that high IFN-gamma levels were associated with a marked reduction of the risk of fibrosis (p = 0.01; OR, 0.1); in contrast, high TNF-alpha levels were associated with an increased risk (p = 0.05; OR, 4.6) of periportal fibrosis. Moreover, infection levels were negatively associated with IFN-gamma production. These results with observations in experimental models strongly suggest that IFN-gamma plays a key role in the protection of S. mansoni-infected patients against periportal fibrosis, whereas TNF-alpha may aggravate the disease.
Using sensors sensibility toward sensor localization and K-coverage problems (2007)

In this paper we present a novel approach to using a sensor's sensibility and laser signal to address both sensor node localization and K-coverage problems. After sensors were randomly deployed, a virtual grid was mapped over the deployment area. Location guided laser beams are projected to the centers of grid cells to trigger sensors within one hop of communication range to form sensor clusters in the virtual grid. Therefore, all clusters are aware of their locations within the precision of location guided laser beams. We assume there are redundant sensors in each cluster. Thus the cluster members can operate alternatively (duty-cycle) in active or sleep modes under the coordination of the cluster head to conserve energy while providing sufficient and robust coverage in the presence of both node power depletions and unexpected failures. We introduce two distributed algorithms to form sensor clusters and to manage cluster members in duty cycles while maintaining the required K-coverage. Simulation and analysis results show that our algorithms scales well with overhead cost as a linear function of sensor population in terms of energy consumption.
Silicon Photonic Wavelength-Tunable Laser Diode With Asymmetric Mach–Zehnder Interferometer (2014)

We fabricated wavelength-tunable laser diodes using a Si photonic wavelength filter that consists of ring resonators and an asymmetric Mach-Zehnder interferometer. The footprint of the optical cavity including the semiconductor optical amplifier is small, 2.6 mm × 0.5 mm, which is about 1/9 of those for tunable laser diodes made of silicon oxynitride. The wavelength could be tuned over approximately 62 nm, which covers the entire L-band of the optical communication wavelength range. The maximum output power reaches 42.2 mW. Furthermore, a spectral line width narrower than 100 kHz was obtained. Such tunable laser diodes with narrow spectral line widths are suitable as light sources integrated into other digital coherent devices.
Two interleukin 1 genes in the mouse: cloning and expression of the cDNA for murine interleukin 1 beta. (1986)

A human interleukin 1 beta (IL 1 beta) cDNA probe was utilized to identify a homologous murine cDNA clone. The murine cDNA encodes a 269-residue protein which is 67% homologous to human IL 1 beta. The murine sequence was engineered for expression in mammalian cells and directs the synthesis of biologically active IL 1. This protein, termed murine IL 1 beta, is only 22% homologous with the previously described murine IL 1 sequence. Both IL 1 alpha and IL 1 beta are encoded by single genes, but IL 1 beta mRNA is about fivefold more abundant in a stimulated macrophage cell line.
Synthesis of γ-Oxosenecioates. Flavor of Watermelon (1960)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of γ-Oxosenecioates. Flavor of WatermelonKeiiti Sisido, Kiyosi Kondô, Hitosi Nozaki, Minoru Tuda, and Yôko UdôCite this: J. Am. Chem. Soc. 1960, 82, 9, 2286–2288Publication Date (Print):May 1, 1960Publication History Published online1 May 2002Published inissue 1 May 1960https://doi.org/10.1021/ja01494a046RIGHTS & PERMISSIONSArticle Views259Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (410 KB) Get e-Alerts Get e-Alerts
A Predictive Video-on-Demand Bandwidth Management Using the Kalman Filter over Heterogeneous Networks (2008)

In order to adapt the quality of an on-demand video stream over a time-varying bandwidth channel, a network-aware bandwidth estimation and rate control scheme are required. This paper proposes a predictive video-on-demand (VoD) bandwidth management and a feedback-based buffer control scheme for streaming fine granular scalability videos over wired/WLAN/3G networks. The predictive VoD bandwidth management includes two parts: bandwidth estimation and rate adaptation. According to the measured information of packet round-trip-time, loss-rate, delay jitter and received bit-rate, an improved Kalman filter is proposed to predict an available bandwidth recursively, and to determine a proper transmission rate in consideration of buffer fullness of a decoder. The optimal parameters of the Kalman filter, e.g. a transition matrix and error covariances, can be initialized, converged and adapted to characteristics of the current network. In our experiments, distinct network traffic models are simulated in comparison with pathChirp and one Republic of China patent. The corresponding estimation results with respect to network information are also exhibited in the real networks.
Development of an Invar (Fe-36Ni) shadow mask for color cathode ray tubes (1988)

An Invar shadow mask was developed for color television tubes. Crystal faces on the rolled material surface are concentrically
Interactive Volume Rendering with Dynamic Ambient Occlusion and Color Bleeding (2008)

Abstract We propose a method for rendering volumetric data sets at interactive frame rates while supporting dynamic ambient occlusion as well as an approximation to color bleeding. In contrast to ambient occlusion approaches for polygonal data, techniques for volumetric data sets have to face additional challenges, since by changing rendering parameters, such as the transfer function or the thresholding, the structure of the data set and thus the light interactions may vary drastically. Therefore, during a preprocessing step which is independent of the rendering parameters we capture light interactions for all combinations of structures extractable from a volumetric data set. In order to compute the light interactions between the different structures, we combine this preprocessed information during rendering based on the rendering parameters defined interactively by the user. Thus our method supports interactive exploration of a volumetric data set but still gives the user control over the most important rendering parameters. For instance, if the user alters the transfer function to extract different structures from a volumetric data set the light interactions between the extracted structures are captured in the rendering while still allowing interactive frame rates. Compared to known local illumination models for volume rendering our method does not introduce any substantial rendering overhead and can be integrated easily into existing volume rendering applications. In this paper we will explain our approach, discuss the implications for interactive volume rendering and present the achieved results.
Gas identification system using graded temperature sensor and neural net interpretation (2018)

Abstract: "An innovative approach is described for enhancing the selectivity of an integrated multi-element thick film gas sensor. A temperature gradient maintained along the sensor surface induces spatial sensitivity and selectivity gradients. The response map of the sensor is examined in the vapor of several organic compounds and their binary mixtures. Subtle but recognizable and separable signatures are observed. Emphasis is on identification, since quantitation of identified mixtures is straightforward. An effective and robust classification technique using a neural network trained via the back propagation method is described."
Conducting metallophthalocyanine 2D covalent organic frameworks: the role of central metals in controlling π-electronic functions (2012)

Phthalocyanine covalent organic frameworks with different central metals are synthesized, and the AA-stacking structure of the 2D polymer sheets results in periodic phthalocyanine π-columns. The central metals control the π-electronic functions, including the improvement of light absorbance, the ease of carrier transport, and the photocurrent gain.
Laparoscopic Verses Open Gastric Bypass to Treat Morbid Obesity (2004)

From the Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. Reprints: Robert E. Brolin, MD, Adjunct Professor of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA. Email: [email protected].