gebhart/patrepeval huggingface dataset:
Herpes Simplex Virus 1 Gene Products Occlude the Interferon Signaling Pathway at Multiple Sites (2004)

Earlier studies have shown that herpes simplex virus 1 (HSV-1) blocks the interferon response pathways, at least at two sites, by circumventing the effects of activation of protein kinase R by double-stranded RNA and interferon and through the degradation of promyelocytic leukemia protein (PML) since interferon has no antiviral effects in PML(-/-) cells. Here we report on two effects of viral genes on other sites of the interferon signaling pathway. (i) In infected cells, Jak1 kinase associated with interferon receptors and Stat2 associated with the interferon signaling pathway rapidly disappear from infected cells. The level of interferon alpha receptor is also reduced, albeit less drastically at times after 4 h postinfection. Other members of the Stat family of proteins were either decreased in amount or posttranslationally processed in a manner different from those of mock-infected cells. The decrease in the levels of Jak1 and Stat2 may account for the decrease in the formation of complexes consisting of Stat1 or ISGF3 and DNA sequences containing the interferon-stimulated response elements after exposure to interferon. (ii) The disappearance of Jak1 and Stat2 was related at least in part to the function of the virion host shutoff protein, the product of the viral U(L)41 gene. Consistent with this observation, a mutant lacking the U(L)41 gene and treated with interferon produced lesser amounts of a late protein (U(L)38) than the wild-type parent. We conclude that HSV-1 blocks the interferon signaling pathways at several sites.
ChemInform Abstract: Cocatalysts for Metal‐Catalyzed Olefin Polymerization: Activators, Activation Processes, and Structure—Activity Relationships (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Coherent Profiles: Enabling Efficient Reuse Distance Analysis of Multicore Scaling for Loop-based Parallel Programs (2011)

Reuse distance (RD) analysis is a powerful memory analysis tool that can potentially help architects study multicore processor scaling. One key obstacle though is multicore RD analysis requires measuring concurrent reuse distance (CRD) profiles across thread-interleaved memory reference streams. Sensitivity to memory interleaving makes CRD profiles architecture dependent, preventing them from analyzing different processor configurations. For loop-based parallel programs, CRD profiles shift coherently to larger CRD values with core count scaling because interleaving threads are symmetric. Simple techniques can predict such shifting, making the analysis of numerous multicore configurations from a small set of CRD profiles feasible. Given the ubiquity and scalability of loop-level parallelism, such techniques will be extremely valuable for studying future large multicore designs. This paper investigates using RD analysis to efficiently analyze multicore cache performance for loop-based parallel programs, making several contributions. First, we provide in depth analysis on how CRD profiles change with core count scaling. Second, we develop techniques to predict CRD profile scaling, in particular employing reference groups to predict coherent shift, and evaluate prediction accuracy. Third, we show core count scaling only degrades performance for last level caches (LLCs) below 16MB for our benchmarks and problem sizes, increasing to 64 - 128MB if problem size scales by 64x. Finally, we apply CRD profiles to analyze multicore cache performance. When combined with existing problem scaling prediction, our techniques can predict LLC MPKI to within 11.1% of simulation across 1,728 configurations using only 36 measured CRD profiles.
Hypertension in mice lacking the proatrial natriuretic peptide convertase corin (2005)

Atrial natriuretic peptide (ANP) is a cardiac hormone that regulates blood pressure. In cardiomyocytes, the hormone is synthesized as a precursor, proatrial natriuretic peptide (pro-ANP), which is proteolytically converted to active ANP. Corin is a cardiac transmembrane serine protease that has been shown to process pro-ANP in vitro, but its physiological importance had not been established. Here, we show that corin-deficient (Cor-/-) mice develop normally during embryogenesis and survive to postnatal life. Cor-/- mice have elevated levels of pro-ANP but no detectable levels of ANP as compared with WT littermates. Infusion of an active recombinant soluble corin transiently restores pro-ANP conversion, resulting in the release of circulating biologically active ANP. Using radiotelemetry to assess blood pressure, we find that Cor-/- mice have spontaneous hypertension as compared with WT mice, and it is enhanced after dietary salt loading. Pregnant Cor-/- mice demonstrate late-gestation proteinuria and enhanced high blood pressure during pregnancy. In addition, Cor-/- mice exhibit cardiac hypertrophy resulting in a mild decline in cardiac function later in life. Thus, our data establish corin as the physiological pro-ANP convertase and indicate that corin deficiency may contribute to hypertensive heart disease.
Role of PTEN nuclear translocation in excitotoxic and ischemic neuronal injuries following stroke (2012)

Stroke is a leading cause of death and disability in developed countries. About 87% of stroke cases results from blood vessel(s) occlusion in the brain, leading to neuronal death and neurological impairment (Lloyd-Jones et al., 2010). The ischemic progression likely involves multiple events, and increasing evidence showed that the ischemic neuronal death is caused, at least in part, by over-activation of N-methyl-Daspartate subtype glutamate receptors (NMDARs) (Rothman, 1983, Rothman, 1984, Simon et al., 1984). A large number of pre-clinical studies showed that NMDAR antagonists have strong neuroprotective effects against ischemic insults (Park et al., 1988b, Bullock et al., 1990). However, none of the following human clinical trials have succeeded yet (Muir, 2006). Several explanations have been suggested (Gladstone et al., 2002), including the following two major reasons that may be overcome by the novel therapeutics proposed here. First, the stroke patient inclusion periods (>6 hours) used by most clinical trials are beyond the therapeutic time window (<1 hour) of NMDAR antagonists. Second, NMDAR antagonists, when used at the concentration required to block excitotoxicity, also abolish the pro-survival downstream cascades of NMDARs, thus leading to intolerable side effects. Therefore, instead of aiming at the receptor per se, my current study turns to focus on identifying NMDAR’s downstream death signals, which may permit a much wider therapeutic time window and are solely involved in pro-death signaling pathways of NMDARs. My results suggest that PTEN (phosphatase and tensin homolog deleted on chromosome TEN) is such a candidate. Both NMDA stimulation on cultured neurons (in vitro) and ischemic insults in rats (in vivo) can trigger ubiquitination-dependent PTEN translocation into the nucleus. Inhibition of PTEN nuclear translocation using an interfering peptide (Tat-K13) can significantly reduce the excitotoxic/ischemic neuronal injuries both in vitro and in vivo. Most excitingly, the intervention time window of PTEN nuclear translocation (6 hours post-ictus) is much wider than that of the only clinically available anti-stroke drug named tissue plasminogen activator (3 hours) (NINDS, 1995). These findings strongly suggest that PTEN nuclear translocation is a critical step leading to excitotoxic/ischemic neuronal injuries, and Tat-K13 represents a potential therapeutic strategy for stroke treatment.
3D Printed Passive Compliant and Articulating Prosthetic Ankle Foot (2017)

The human ankle is crucial to mobility as it counteracts the forces and moments created during walking. Around 85% of the 1.7 million people in the United States living with limb loss are transtibial (below knee) and transfemoral (above knee) amputees who are missing their ankle and require a prosthetic. This paper presents the Compliant and Articulating Prosthetic Ankle (CAPA) foot, a solution that uses torsional springs to store and release energy at three different locations on the mechanism, assisting in forward motion. The CAPA foot utilizes 3D printing and allows for the full ankle range of motion in the sagittal plane. Testing was performed with the CAPA foot on the Computer Assisted Rehabilitation Environment on an able-bodied person wearing a prosthetic simulator. Compared to the conventional non-articulating Solid Ankle Cushioned Heel foot, the CAPA foot is shown to better mimic the ground reaction forces and ankle angles of a healthy gait.
Development of Two-Layered Zn-Fe Alloy Electroplated Steel Sheet-New Coated Steel Sheet for Automotive Body (1984)

<div class="htmlview paragraph">There is an urgent need to develop a now type of coated steel, which will meet the requirements for high strength steel and protection against corrosion caused by chipping. According to the results of various improvement studies on the composition of coating layers and their properties, the low Zn/Fe ratio on the surface layer should show good paintability.</div> <div class="htmlview paragraph">By sequence of studies we have developed a two layered Zn-Fe alloy electroplated steel sheet with excellent corrosion resistance, and optimum press formability and paintability compared to cold rolled sheet.</div> <div class="htmlview paragraph">Finally, we have confirmed the effectiveness of a newly developed electroplated sheet through corrosion tests of an actual auto body and have succeeded in applying the new steel to the mass production line.</div>
Onion morphology and microstructure of polyhedral serpentine (2007)

We describe the shape and internal structure of polyhedral spheroids found in serpentinized peridotites. Serpentine spheroids resemble geodesic domes made of ~160 to 180 triangular facets. At facet edges, the nested layers bend by ~14° along their three <010> crystallographic directions, resulting in an onion-like structure with lateral continuity of the layers. The stacking of the serpentine layers within sectors is controlled by interlayer bonding. These polyhedral onions correspond to a novel type of spherical nanostructure for layered materials
The Role of Function of Speech in the Regulation of Behavior of Mentally Retarded Children : Examination of the Meaning of Mental Index of Retarded Children I (1966)

An experiment was designed to determine the role of speech in the regulation of behavior of mentally retarded children from the mental developmental view-point, and to testify the meaning of MA measured by Binet-Intelligence-Scale as developmental stage of retarded children. Four groups (Table 1) of retarded children graded in MA were chosen as the subjects for the experiment of the formation of motor conditioned reflexes and voluntary movements through verbal reinforcement, and the results were compared with those of A.R. Luria's findings in normal children which assumed the parallel relationship between the mental level or chronological age and interaction of the first and second signal systems. The main results were as follows: (1) the increase of the responses in both speech and motor in the conceptual level with MA was confirmed, but (2) the function of speech as conditioned inhibitors in these retarded children did not confirm up to MA five, and (3) interaction of the first and second signal systems in feebleminded children was more retarded than in normal children and formed over MA seven, and (4) when we compared the content of speech of retarded children with that of normal children, we could disclose some quatitative characteristics of the retarded which were not identified by MA; e.g. the dominance of the mechanical words or absurd speech which was unsupported by the proper generalization or conceptualization of the speech.
Using Dedicated Short Range Communications for Vehicle Safety Applications - the Next Generation of Collision Avoidance (2009)

This paper provides the status of the Vehicle Safety Communications-Applications (VSC-A) research project, which was designed to determine if dedicated short range communications (DSRC) paired with accurate vehicle positioning can improve upon autonomous vehicle-based safety systems or enable new communication-based safety applications. This three-year project is a collaborative effort between government and industry to develop the underlying pre-competitive elements needed to enable the deployment of vehicle-to-vehicle (V2V) communication-based crash avoidance applications. The effort includes the development of core software and hardware modules and prototype applications. These use DSRC in conjunction with enhancements to vehicle positioning systems to demonstrate crash avoidance capabilities, which are interoperable between different vehicle manufacturers. To support the development of interoperable systems, the partners have participated in standards and security protocol development activities. The core modules and prototype applications are implemented on a five-vehicle testbed fleet, which will be used to conduct objective tests that are then used to validate minimum performance specifications established as part of this project. These tests will in turn support a safety benefits estimation process to determine the potential for preventing or mitigating crashes and associated fatalities, injuries, and property damage. The full text of this paper may be found at: http://www-nrd.nhtsa.dot.gov/pdf/esv/esv21/09-0330.pdf For the covering abstract see ITRD E145407.
Unipolar self-doping behavior in perovskite CH3NH3PbBr3 (2015)

Recent theoretical and experimental reports have shown that the perovskite CH3NH3PbI3 exhibits unique ambipolar self-doping properties. Here, we show by density-functional theory calculation that its sister perovskite, CH3NH3PbBr3, exhibits a unipolar self-doping behavior—CH3NH3PbBr3 presents only good p-type conductivity under thermal equilibrium growth conditions. We further show that despite a large bandgap of 2.2 eV, all dominant defects in CH3NH3PbBr3 create shallow levels, which partially explains the ultra-high open-circuit voltages achieved by CH3NH3PbBr3-based thin-film solar cells. Our results suggest that the perovskite CH3NH3PbBr3 can be both an excellent solar cell absorber and a promising low-cost hole-transport material for lead halide perovskite solar cells.
High rate of <i>CAD</i> gene amplification in human cells deficient in MLH1 or MSH6 (2001)

MutS and MutL homologs have been implicated in multiple genetic stabilization pathways. The activities participate in the correction of DNA biosynthetic errors, are involved in cellular responses to certain types of DNA damage, and serve to ensure the fidelity of genetic recombination. We show here that the rate of CAD (carbamyl-P synthetase/aspartate transcarbamylase/dihydroorotase) gene amplification is elevated 50- to 100-fold in human cell lines deficient in MLH1 or MSH6, as compared with mismatch repair-proficient control cells. Fluorescence in situ hybridization indicates that these amplification events are the probable consequence of unequal sister chromatid exchanges involving chromosome 2, as well as translocation events involving other chromosomes. These results implicate MutS alpha and MutL alpha in the suppression of gene amplification and suggest that defects in this genetic stabilization function may contribute to the cancer predisposition associated with mismatch repair deficiency.
Improved Diagnostic and Prognostic Power of Combined Delta Neutrophil Index and Mean Platelet Volume in Pediatric Sepsis. (2018)

This study aims to evaluate the diagnostic and prognostic significance of white blood cell (WBC) and platelet parameters measured by automated hematology analyzers in pediatric sepsis. The study included 232 pediatric patients whose C-reactive protein test had been requested for evaluation of infection or inflammation at a pediatric tertiary hospital. The patients were allocated to control, systemic inflammatory response syndrome (SIRS) without infection, and sepsis groups. An ADVIA 2120i hematology system was used to measure the delta neutrophil index (DN) and platelet parameters including platelet count, mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT), and immature platelet fraction (IPF). A Coulter LH750 hematology analyzer was used to measure the neutrophil volume distribution width (NDW) and monocyte volume distribution width (MDW). The levels of DN, NDW, MDW, MPV, and IPF each gradually increased from the control to SIRS without infection to sepsis. For sepsis, the highest area under the curve (AUC) value was observed for DN. In addition, NDW, MDW, platelet count, PCT, and IPF showed higher AUC values than C-reactive protein. WBC, DN, NDW, MDW, MPV, PDW, PMDW, and IPF were valuable markers for predicting mortality. Of note, the combination of DN and MPV showed a significantly higher prognostic value when compared with individual DN or MPV. Therefore, considering that DN and MPV are each included in a routine complete blood cell count, their combination can be an alternative parameter to assist in achieving a fast and accurate diagnosis and predict the prognosis of sepsis in pediatric patients.
A 2.62-GHz class-F power amplifier with lumped-element and transmission line network design (2017)

A 2.62-GHz class-F power amplifier with independent analogous method, lumped-element network design is presented. The amplifier is designed using CGH40010 GaN HEMT transistor device with 5 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sup> order low pass structure at the lumped-element output network. A transmission line networks has been used in transformation of both input and output of the amplifier. Optimum fundamental impedance matching networks and optimization are applied at the frequencies of interest to controlling the even and odd harmonics, to allow fundamental frequency deliver to the load. The power amplifier achieves 81.5% peak efficiency at 18.1dBm output power.
Modern Insecticides and World Food Production (1960)

Modern insecticides and world food production , Modern insecticides and world food production , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی
On multi-hop forwarding over WBSS-based IEEE 802.11(p)/1609 networks (2009)

The IEEE 802.11(p)/1609 network is a promising candidate for future vehicular communication networks. Due to the deployment cost consideration, roadside units (RSUs) in such networks are usually installed only at hot spots and intersections, causing the service coverage of RSUs to be discontinuous. To overcome this problem, multihop data forwarding among vehicles can be used to extend the service coverage of RSUs. In this paper, we propose a receiver-centric WBSS (Wave Basic Service Set)-creating scheme to support multihop data forwarding in WBSS-based IEEE 802.11(p)/1609 networks and evaluate its performances using simulations. Our simulation results show that this scheme outperforms a typical sender-centric WBSS-creating scheme on end-to-end flow goodputs under different traffic loads.
Physical Therapy and Exercise-Induced Bronchospasm (1975)

Most asthmatic children develop a significant degree of bronchospasm from exercise which restricts their active participation in outdoor play and sports and sometimes leads to many social and psychological problems. No specific physiological or immunological factors have yet been found to explain the basis of this exercise-induced bronchospasm (EIB). It is also unrelated to age, sex, or severity of asthma. Some investigators have hypothesized that EIB may be a conditioned response resulting from the association between the physical exertion and breathing difficulty which is frequently experienced by these children during their asthmatic attacks. Physical activity programs, organized around themes of progressive and interval training periods, may be quite helpful in reducing the intensity of EIB.
Microcellular structures and their performance (2003)

The author presents some basic microcellular structures for use in the city environment and considers their performance, in terms of C/I. The advantages and disadvantages are discussed. The capacity is estimated for different combinations of cell plans, including multilayer structures. It is shown that cell structures based on simulcast techniques achieve better capacity if base station density is taken into account.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Frontal brain asymmetry and emotional reactivity: A biological substrate of affective style (1993)

Individuals differ dramatically in the quality and intensity of their response to affectively evocative stimuli. On the basis of prior theory and research, we hypothesized that these individual differences are related to variation in activation of the left and right frontal brain regions. We recorded baseline brain electrical activity from subjects on two occasions 3 weeks apart. Immediately following the second recording, subjects were exposed to brief positive and negative emotional film clips. For subjects whose frontal asymmetry was stable across the 3-week period, greater left frontal activation was associated with reports of more intense positive affect in response to the positive films, whereas greater right frontal activation was associated with more intense reports of negative affect in response to the negative film clips. The methodological and theoretical implications of these data are discussed.
Solving Constrained Multiple Resource Networks Both Forward and Backward Using Brooks Algorithm (2001)

Many Brooks algorithm (BAG)-based heuristics have been proposed to solve the constrained multiple resource problem. BAG starts at the beginning of a project network, determines a list of available tasks, and then uses a heuristic to select a task to schedule. This research modifies BAG to solve the project network in both a forward and backward (F&B) direction. This modified BAG approach was used on Patterson's 110 test problems with several selection heuristics, such as ACTIM, latest finish time (LFT), resource over time (ROT), and ACTRES. Results of this research show that solving the networks in both the F&B directions led to improvements of more than 30% for the average error, the maximum error and the percentage of optimum solutions found when compared to the traditional BAG approach.