gebhart/patrepeval huggingface dataset:
Transcriptional control of glutathione S-transferase gene expression by the chemoprotective agent 5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione (oltipraz) in rat liver. (1990)

The substituted 1,2-dithiole-3-thione oltipraz [5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione] protects against the acute and chronic toxicities of many xenobiotics, including aflatoxin B1, in rodents. These protective effects are mediated, in part, through elevation of glutathione S-transferase (GST) activities. Because studies by Coles et al. [Carcinogenesis (Lond.), 6: 693-697, 1985] suggested that the detoxication of aflatoxin through conjugation with glutathione is principally catalyzed by GST homodimer YaYa, we have investigated the regulation of the gene coding for the Ya subunit in the liver of F344 rats following dietary administration of oltipraz. Overall GST activity, as measured by conjugation with 1,2-dichloro-4-nitrobenzene or 1-chloro-2,4-dinitrobenzene, as well as the levels of GST Ya protein, was elevated 1.5-fold by 24 h and maximally (2.7- to 3.5-fold) and persistently after 5 days on a purified diet supplemented with 0.075% oltipraz. Steady state mRNA levels for GST subunit Ya, as quantified by slot blot analysis using rat liver GST complementary DNA clone pGTB38, were also elevated by 24 h, with a maximal elevation of 3-fold observed at 3 days. However, mRNA levels decreased thereafter, despite continued feeding of oltipraz. Northern blot analyses demonstrated that oltipraz did not alter the size of GST mRNA. Transcriptional activity of the GST Ya gene, as determined by nuclear run-off analysis, was increased 2-fold after 24-h feeding of oltipraz, was maximally induced 2.4-fold at 3 days, and returned to near control levels at 7 days, despite sustained feeding of oltipraz. Modulation of GST activity by oltipraz was not accompanied by changes in the methylation pattern at internal sites of the GST Ya gene. These results show that the initial induction of hepatic GST activity during oltipraz exposure correlates with changes in steady state levels of GST mRNA and rates of GST gene transcription; however, the continued elevation of GST enzymatic activities and GST Ya protein levels in the face of declining GST Ya mRNA levels and transcription rates suggests that additional mechanisms may be involved in regulating GST Ya expression by oltipraz.
A New Synthesis of Substituted 8-Aminopurine Derivatives (1973)

Abstract The treatment of 6-amino-5-nitrosopyrimidines with Vilsmeier-type reagents (substituted formamides and phosphorus oxychloride) afforded substituted 8-aminopurines; the treatment of 6-amino-4-hydroxy-2-methyl-5-nitrosopyrimidine gave 2-chloromethyl-8-dimethylamino-6-hydroxypurine.
Control of Wind Turbines (2011)

Wind energy is a fast-growing interdisciplinary field that encompasses multiple branches of engineering and science. Despite the growth in the installed capacity of wind turbines in recent years, larger wind turbines have energy capture and economic advantages, the typical size of utility scale wind turbines has grown by two orders of magnitude. Since modern wind turbines are large, flexible structures operating in uncertain environments, advanced control technology can improve their performance.The goal of this article is to describe the technical challenges in the wind industry relating to control engineering.
Frequent Ventricular Ectopy after Exercise as a Predictor of Death (2003)

Frequent ventricular ectopy during recovery after exercise is a better predictor of an increased risk of death than ventricular ectopy occurring only during exercise.
Effect of recombinant human fibronectin polypeptide CH50 on growth and metastasis of melanoma. (1999)

CH50 inhibited tumor growth and metastasis of murine melanoma. The antitumor effect of CH50 is related to its adhesion ability to melanoma B16 cells and enhancing macrophage cytotoxicity.
Clinical Significance of Perioperative Immunonutrition for Patients with Esophageal Cancer (2007)

This study reveals that the perioperative immune-enhanced formula may be superior to postoperative control enteral formulas in terms of reducing surgical wound infection and postoperative SIRS, which may result in serious postoperative complications for patients who have undergone esophagectomy.
Development and psychometric testing of the Canine Owner-Reported Quality of Life questionnaire, an instrument designed to measure quality of life in dogs with cancer (2018)

OBJECTIVE To describe development and initial psychometric testing of an owner-reported questionnaire designed to standardize measurement of general quality of life (QOL) in dogs with cancer. DESIGN Key-informant interviews, questionnaire development, and field trial. SAMPLE Owners of 25 dogs with cancer for item development and pretesting and owners of 90 dogs with cancer for reliability and validity testing. PROCEDURES Standard methods for development and testing of questionnaire instruments intended to measure subjective states were used. Items were generated, selected, scaled, and pretested for content, meaning, and readability. Response items were evaluated with exploratory factor analysis and by assessing internal consistency (Cronbach α) and convergence with global QOL as determined with a visual analog scale. Preliminary tests of stability and responsiveness were performed. RESULTS The final questionnaire-which was named the Canine Owner-Reported Quality of Life (CORQ) questionnaire-contained 17 items related to observable behaviors commonly used by owners to evaluate QOL in their dogs. Several items pertaining to physical symptoms performed poorly and were omitted. The 17 items were assigned to 4 factors-vitality, companionship, pain, and mobility-on the basis of the items they contained. The CORQ questionnaire and its factors had high internal consistency (Cronbach α = 0.68 to 0.90) and moderate to strong correlations (r = 0.49 to 0.71) with global QOL as measured on a visual analog scale. Preliminary testing indicated good test-retest reliability and responsiveness to improvements in overall QOL. CONCLUSIONS AND CLINICAL RELEVANCE The CORQ questionnaire was a valid, reliable owner-reported questionnaire that measured general QOL in dogs with cancer and showed promise as a clinical trial outcome measure for quantifying changes in individual dog QOL occurring in response to cancer treatment and progression.
A micro-cavity fluidic dye laser (2003)

We have successfully fabricated and characterized a micro-cavity fluidic dye laser with metallic mirrors, which can be integrated with other microfluidic systems without adding further process steps. A laser dye solution is pumped through a microfluidic channel containing the laser cavity. The microfluidic channel structure, which is formed in SU-8 photoresist, is sandwiched between Pyrex glass wafers, bonded together at low temperature by means of SU-8. The laser was characterized using Rhodamine 6G laser dye dissolved in ethanol as the active medium, and optically pumped by a frequency doubled Nd:YAG laser. The dye solution was optimized, and lasing was observed at a wavelength of 570 nm with a full width half maximum linewidth of 5.7 nm and the optical pumping power density threshold for lasing was 34 mW cm−2.
Quality improvement methods for hexahedral element meshes adaptively generated using grid‐based algorithm (2011)

SUMMARY The quality of finite element meshes is one of the key factors that affects the accuracy and reliability of numerical simulation results of many science and engineering problems. In order to solve the problem wherein the surface elements of the mesh generated by the grid‐based method have poor quality, this paper studied mesh quality improvement methods, including node position smoothing and topological optimization. A curvature‐based Laplacian scheme was used for smoothing of nodes on the C‐edges , which combined the normal component with the tangential component of the Laplacian operator at the curved boundary. A projection‐based Laplacian algorithm for smoothing the remaining boundary nodes was established. The deviation of the newly smoothed node from the practical surface of the solid model was solved. A node‐ and area‐weighted combination method was proposed for smoothing of interior nodes. Five element‐inserting modes, three element‐collapsing modes and three mixed modes for topological optimization were newly established. The rules for harmonious application and conformity problem of each mode, especially the mixed mode, were provided. Finally, several examples were given to demonstrate the practicability and validity of the mesh quality improvement methods presented in this paper. Copyright © 2011 John Wiley & Sons, Ltd.
Respiratory support in patients with acute respiratory distress syndrome: an expert opinion (2017)

Acute respiratory distress syndrome (ARDS) is a common condition in intensive care unit patients and remains a major concern, with mortality rates of around 30-45% and considerable long-term morbidity. Respiratory support in these patients must be optimized to ensure adequate gas exchange while minimizing the risks of ventilator-induced lung injury. The aim of this expert opinion document is to review the available clinical evidence related to ventilator support and adjuvant therapies in order to provide evidence-based and experience-based clinical recommendations for the management of patients with ARDS.
The Information Content of Equity REIT Bank Credit Facility Announcements (2008)

Executive Summary. This study examines the wealth effects surrounding announcement of flexible bank credit facilities arranged by Equity Real Estate Investment Trusts (EREITs) during the modern REIT era, 1994-2004. The findings reveal significantly positive shareholder wealth effects in a sample of 83 announcements of new credit lines. Announcements of increases in existing credit lines have no shareholder wealth implications. Wealth creation is greater when the amount of the credit facility is larger than average, measured as a percentage of the firm’s total assets. Consistent with the relationship banking literature, this wealth creation is attributed here to a signal of positive asymmetric information regarding the firm’s investment opportunity set.
Three-dimensional recognition of occluded objects by using computational integral imaging (2006)

We have proposed a method to recognize partially occluded three-dimensional (3D) objects by using 3D volumetric reconstruction integral imaging (II). An II system captures multiple perspectives of occluded objects by using a microlens array. The reconstruction of the occluded 3D scene and target recognition are done digitally to reduce the effects of the occlusion. To verify system performance, we have implemented an optimum filter for object recognition. Both two-dimensional (2D) images and 3D II volumetric reconstructed images are considered. The correlation results of occluded 3D images for volumetric reconstruction show substantial improvements compared with those for conventional 2D imaging of occluded images.
World's First Application of "Self-Locating" Technology for Re-Entry of Milled Casing Windows (2001)

Abstract Traditionally, operators have had limited options for conducting remedial work on lateral re-entries through milled-casing windows. This limitation is due to the necessity of using a "bent joint" of pipe to guide tools through the window. If a bent joint of pipe cannot be attached to the end of the assembly (e.g. a drilling assembly), a whipstock is required to deflect the assembly out the window. Setting a conventional whipstock requires the use of orienting tools that add significantly to the wellcost. This paper describes the world's first applications of unique technology that helps solve these problems by facilitating the exiting of milled-casing windows with service tool assemblies during remedial operations. The system uses the patent-pending "self-locating" lateral re-entry technology as an integral component of the Lateral Re-entry Whipstock to assure the proper orientation and elevation of the whipstock tool face with the casing exit window. The technology described in this paper has bearing on TAML Level II 1 junction re-entry operations for clean out, production enhancement, increased reservoir drainage, zonal isolation, and re-completion of lateral wellbores in multilateral completions.
Proinflammatory role of aquaporin‐4 in autoimmune neuroinflammation (2011)

Aquaporin-4 (AQP4) deficiency in mice reduces neuroinflammation in experimental autoimmune encephalomyelitis (EAE) produced by active immunization with myelin oligodendrocyte glycoprotein peptide (MOG). Potential mechanisms for the protective effect of AQP4 deficiency were investigated, including AQP4-dependent leukocyte and microglia cell function, immune cell entry in the central nervous system (CNS), intrinsic neuroinflammation, and humoral immune response. As we found with active-immunization EAE, neuroinflammation was greatly reduced in AQP4-knockout mice in adoptive-transfer EAE. AQP4 was absent in immune cells, including activated T lymphocytes. The CNS migration of fluorescently labeled, MOG-sensitized T lymphocytes was comparable in wild-type and AQP4-knockout mice. Microglia did not express AQP4. Serum anti-AQP4 antibodies were absent in EAE. Remarkably, intracerebral injection of LPS produced much greater neuroinflammation in wild-type than in AQP4-knockout mice, and cytokine (TNF-α and IL-6) secretion was reduced in astrocyte cultures from AQP4-knockout mice. Adenovirus-mediated expression of AQP4, or of an unrelated aquaporin, AQP1, increased cytokine secretion in astrocyte and nonastrocyte cell cultures, supporting the involvement of aquaporin water permeability in cytokine secretion. Our data suggest an intrinsic proinflammatory role of AQP4 involving AQP4-dependent astrocyte swelling and cytokine release. Reduction in AQP4 water transport may be protective in neuroinflammatory CNS diseases.
Comparison of 5-fluorouracil alone, 5-fluorouracil with levamisole, and 5-fluorouracil with hepatic irradiation in the treatment of patients with residual, nonmeasurable, intra-abdominal metastasis after undergoing resection for colorectal carcinoma (2001)

This study showed no treatment advantage for any of the combined modalities over 5-FU alone in this group of patients with intra-abdominal, nonmeasurable disease.
Design of diets based on gene expression data produces foods which improve renal health and ameliorate sarcopenic obesity (246.3) (2014)

Etiology of aging manifests reduced renal health and sarcopenic obesity with characteristic changes in gene expression. Cats were fed a control food (CD), known to improve indices of age‐related pathology, or one of two diets (ED1 & ED2; n = 27 each diet) that contained ingredients producing expression profiles reflective of a young animal in cell models. The protocol was approved by IACUC. Health was monitored via clinical and physical indices. Results from ED1 & ED2 were the same and were significant with P < 0.05, unless noted. Renal health improved on all diets, as indicated by improved glomerular filtration rate (GFR) and reduced levels of symmetrical dimethylarginine. Analysis of plasma metabolomics showed that creatine, betaine, dimethylarginines, acylcarnitines and cortisol were negatively correlated with GFR, indicating possible value as renal health markers. Body weight was unchanged, but cats fed ED1 & ED2 lost fat mass and retained (ED1) or increased (ED2) lean mass. Metabolomics showed that circulating amino acids, including the felinine analog of glutathione, and glycerophospho‐lipids were positively correlated with lean mass. Thus, design of diets based on gene expression data led to foods capable of improving renal health and ameliorating sarcopenic obesity, while metabolomic profiling of cats consuming these foods identified markers predicting ameliorated age‐related co‐morbidities.
Response to Hydrolysed Collagen Protein Supplementation in a Cohort of Pregnant and Postpartum Women (2016)

There is overwhelming evidence that links maternal nutrition during pregnancy with fetal outcomes. This study evaluated the safety and efficacy of Protiva treatment responses in pre and postpartum female subjects between the ages of 19 years and 43 years who entered into this open label study. The protocol was designed to take a twice daily collagen protein supplementation drink during the third trimester and for 10 weeks postpartum. The outcomes were measured against a control group of patients who did not take the protein supplementation. The differences between mean score for the physical health domain of WHOQOL-BREF scale in the Protiva group and the control group were different and met statistical significance (p=0.0003). The study found that 100% of control patients and 95% of Protiva patients had initial serum protein levels below the normal median range and 27% of control patients and 33% of Protiva patients were below normal range. With collagen protein supplementation we were able to demonstrate improved quality of life and wound healing rates and 100% improvement in the protein levels for Protiva patients and a 72% improvement over control patients. Protiva Pregnancy and Protiva New Mom was determined to be safe and well tolerated when taken during pregnancy and post-partum during the study.
New Series of Morpholine and 1,4-Oxazepane Derivatives as Dopamine D<sub>4</sub>Receptor Ligands:  Synthesis and 3D-QSAR Model (2004)

Since the identification of the dopamine D(4) receptor subtype and speculations about its possible involvement in schizophrenia, much work has been put into development of selective D(4) ligands. These selective ligands may be effective antipsychotics without extrapyramidal side effects. This work describes the synthesis of a new series of 2,4-disubstituted morpholines and 2,4-disubstituted 1,4-oxazepanes with selectivity for the dopamine D(4) receptor. A 3D-QSAR analysis using the GRID/GOLPE methodology was performed with the purpose to get a better understanding of the relationship between chemical structure and biological activity. Inspection of the coefficient plots allowed us to identify that regions which are important for affinity are situated around the two benzene ring systems, a p-chlorobenzyl group, and the aliphatic amine belonging to the morpholine or 1,4-oxazepane system. In addition, the size of the morpholine or 1,4-oxazepane ring seems to be important for affinity.
L-Carnitine Supplementation in Humans. The Effects on Physical Performance (1990)

The use of supplementary L-carnitine by athletes has become rather widespread over the recent years even in the absence of unequivocal results from human experimental studies that might support this practice. To justify the above procedure, the most commonly purported reasons are that L-carnitine administration could hypothetically: 1. increase lipid turnover in working muscles leading to glycogen saving and, as a consequence, allow longer performances for given heavy work loads; 2. contribute to the homeostasis of free and esterified L-carnitine in plasma and muscle, the allegation being that the levels of one or more of these compounds may decrease in the course of heavy repetitive exercise. A critical survey of the literature on carnitine metabolism in healthy humans at exercise does not appear to be available. The authors are of the opinion that this paper, besides shedding light into some relevant aspects of energy turnover in muscle, could also be of practical use not only for the physiologists but particularly for the Sport Medicine practitioners.
New GABA‐Modulating 1,2,4‐Oxadiazole Derivatives and Their Anticonvulsant Activity. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Low Cost and Flexible UAV Deployment of Sensors (2017)

This paper presents a platform for airborne sensor applications using low-cost, open-source components carried by an easy-to-fly unmanned aircraft vehicle (UAV). The system, available in open-source , is designed for researchers, students and makers for a broad range of exploration and data-collection needs. The main contribution is the extensible architecture for modularized airborne sensor deployment and real-time data visualisation. Our open-source Android application provides data collection, flight path definition and map tools. Total cost of the system is below 800 dollars. The flexibility of the system is illustrated by mapping the location of Bluetooth beacons (iBeacons) on a ground field and by measuring water temperature in a lake.
Development of Gene Therapy for Gaucher Disease (1998)

The pathobiology of lysosomal storage disorders should dictate the target cell for gene transfer in the development of gene therapy. However, because the pathogenesis of these and most diseases is only partially defined, a variety of gene transfer approaches may need to be studied before a successful therapy is discovered (Table 1). Gaucher disease (GD) is the most common lysosomal storage disorder and is the focus of this chapter.
Changes in intestinal cell proliferation, absorptive capacity and structure in young, adult and old rats. (1990)

Intestinal epithelial morphology, crypt cell production and absorptive function were investigated in 9 groups of rats, aged from 3 to 121 weeks. Absorption per unit length of intestine peaked in the first weeks of life and this was associated with increased villus size, crypt length and absorption per mg tissue weight. Absorption per gut continued to increase throughout life, which could be attributed to a similar increase in intestinal length and weight per cm, despite a decreased absorption per mg in the adult animals. Crypt-villus ratio increased rapidly between 6 and 8 weeks, but then appeared to reach a plateau. Crypt cell production started off at high rate in all sites and then decreased in the young adult. While there was some evidence for a small, non-significant, increase in proliferation in the very old rats, there was no evidence of the marked elevation reported by some workers.
Pyrrolopyrimidine Nucleosides. I. The Synthesis of 4-Substituted 7-(β-<scp>D</scp>-Ribofuranosyl)pyrrolo[2,3-<i>d</i>]pyrimidines from Tubercidin (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPyrrolopyrimidine Nucleosides. I. The Synthesis of 4-Substituted 7-(β-D-Ribofuranosyl)pyrrolo[2,3-d]pyrimidines from TubercidinJohn F. Gerster, Barbara. Carpenter, Roland K. Robins, and Leroy B. TownsendCite this: J. Med. Chem. 1967, 10, 3, 326–331Publication Date (Print):May 1, 1967Publication History Published online1 May 2002Published inissue 1 May 1967https://pubs.acs.org/doi/10.1021/jm00315a008https://doi.org/10.1021/jm00315a008research-articleACS PublicationsRequest reuse permissionsArticle Views179Altmetric-Citations40LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts