gebhart/patrepeval huggingface dataset:
Large scaled analysis of hepatitis B virus (HBV) DNA integration in HBV related hepatocellular carcinomas (2005)

In 61/68 (89.7%) cases, HBV DNA was integrated into cellular genes potentially providing cell growth advantage. Identification of recurrent viral integration sites into genes of the same family allows recognition of common cell signalling pathways activated in hepatocarcinogenesis.
Spectrochemical Studies of a Series of Lactams as Ligands with Nickel(II) and Chromium(III) (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSpectrochemical Studies of a Series of Lactams as Ligands with Nickel(II) and Chromium(III)John H. Bright, Russell S. Drago, David M. Hart, and Stanley K. MadanCite this: Inorg. Chem. 1965, 4, 1, 18–20Publication Date (Print):January 1, 1965Publication History Published online1 May 2002Published inissue 1 January 1965https://pubs.acs.org/doi/10.1021/ic50023a004https://doi.org/10.1021/ic50023a004research-articleACS PublicationsRequest reuse permissionsArticle Views224Altmetric-Citations37LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Linear Decision Rule for Production and Employment Scheduling (1955)

The decision problems involved in setting the aggregate production rate of a factory and setting the size of its work force are frequently both complex and difficult. The quality of these decisions can be of great importance to the profitability of an individual company, and when viewed on a national scale these decisions have a significant influence on the efficiency of the economy as a whole. This paper reports some of the findings of a research team that has been developing new methods to enable production executives to make better decisions and to make them more easily than they can with prevailing procedures. With the cooperation of a manufacturing concern, the new methods have been developed in the context of a set of concrete production scheduling problems that were found in a factory operated by the company. The new method which is presented in this paper, involves: (1) formalizing and quantifying the decision problem (using a quadratic approximation to the criterion function) and (2), calculating a generalized optimal solution of the problem in the form of a (linear) decision rule. Like a rule of thumb, an optimal decision rule prescribes a course of action when it is applied to a particular set of circumstances; but, unlike most rules of thumb, an optimal decision rule prescribes courses of action for which the claim can be made that the decisions are “the best possible,” the meaning of “best” being clearly specified. The ultimate test, of course, must be whether the new decision methods do or do not outperform prevailing decision methods when full allowance is made for the cost of obtaining the optimal decisions.
XBlock-ETH: Extracting and Exploring Blockchain Data From Ethereum (2020)

Blockchain-based cryptocurrencies have received extensive attention recently. Massive data has been stored on permission-less blockchains. The analysis of massive blockchain data can bring huge business values. However, the absence of well-processed up-to-date blockchain datasets impedes big data analytics of blockchain data. To fill this gap, we collect and process the up-to-date on-chain data from Ethereum, which is one of the most popular permission-less blockchains. We name such well-processed Ethereum data as XBlock-ETH, which consists of transactions, smart contracts, and cryptocurrencies (i.e., tokens). However, it is non-trivial to partition and categorize the collected raw Ethereum data to the well-processed datasets since the whole processing procedure requires sophisticated knowledge on software engineering as well as big data analytics. Moreover, we also present basic statistics and exploration for each of the well-processed datasets. Furthermore, we also outline the possible research opportunities based on XBlock-ETH, with the data and code released online.
A self-tuning NLMS adaptive filter using parallel adaptation (1997)

A new adaptive filter algorithm that explicitly self-tunes for enhanced random walk tracking is presented. This algorithm takes measurements of its environment as if it were a random walk, and modifies its convergence-controlling parameter accordingly. The resulting filter makes use of three distinct normalized least-mean-squares (NLMS) filters running on the same inputs and is consequently referred to as parallel adaptation (PA-NLMS). An analysis is provided that accurately predicts PA-NLMS performance in the random walk scenario. We also claim that this algorithm can interpret a far-from-convergence condition as a quickly varying random walk, resulting in nearly optimal NLMS convergence. The effectiveness of the interpretation of the adaptation state as a random walk in these and other environments is also examined by means of simulation. These simulations are also used to compare the performance of the PA-NLMS filter with that of an existing self-tuning algorithm as well as a benchmark NLMS process. Improvements in both convergence and misadjustment at convergence over these existing algorithms are demonstrated.
Selective Synthesis and Characterization of Nanocrystalline EuF<sub>3</sub> with Orthorhombic and Hexagonal Structures (2006)

A simple solution-based procedure employing NaBF4 as the fluoride source has been developed to selectively prepare nanospindles of EuF3 with an orthorhombic structure and nanodisks of EuF3 with a hexagonal structure by controlling the molar ratios of the starting materials. These as-prepared nanocrystals of EuF3 were characterized by XRD, SEM, and TEM. The nanodisks of EuF3 self-assemble into single-crystal column-like nanostructures. The photoluminescence properties of these nanoscale EuF3 species have been investigated.
A Cycling Protein Complex Required for Selective Autophagy (2007)

Survival of environmental stress conditions requires the maintenance of cellular homeostasis. To preserve this balance, cells utilize a degradative mechanism known as autophagy. During this process, in response to starvation or other stresses, bulk cytoplasm is non-specifically sequestered within double-membrane vesicles and delivered to the lysosome/vacuole for subsequent degradation and recycling. The cytoplasm to vacuole targeting (Cvt) pathway is a type of specific autophagy, which occurs constitutively during growing conditions. Here, we examine three autophagy-related (Atg) proteins, Atg9, Atg23 and Atg27, which exhibit a unique localization pattern, residing both at the pre-autophagosomal structure (PAS) and other peripheral sites. These proteins colocalize, interact with one another in vivo, and form a functional complex. Furthermore, all three proteins cycle between the PAS and the other sites, and depend upon one another for this movement. Our data suggest that Atg9, Atg23 and Atg27 play a role in Atg protein retrieval from the PAS. In addition, Atg9 and Atg27 are the only known integral membrane Atg proteins involved in vesicle formation; a better understanding of their function may offer insight into the mechanism of membrane delivery to the PAS, the site of double-membrane vesicle assembly.
Distinct signatures of host–microbial meta-metabolome and gut microbiome in two C57BL/6 strains under high-fat diet (2014)

A combinatory approach using metabolomics and gut microbiome analysis techniques was performed to unravel the nature and specificity of metabolic profiles related to gut ecology in obesity. This study focused on gut and liver metabolomics of two different mouse strains, the C57BL/6J (C57J) and the C57BL/6N (C57N) fed with high-fat diet (HFD) for 3 weeks, causing diet-induced obesity in C57N, but not in C57J mice. Furthermore, a 16S-ribosomal RNA comparative sequence analysis using 454 pyrosequencing detected significant differences between the microbiome of the two strains on phylum level for Firmicutes, Deferribacteres and Proteobacteria that propose an essential role of the microbiome in obesity susceptibility. Gut microbial and liver metabolomics were followed by a combinatory approach using Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR-MS) and ultra performance liquid chromatography time of tlight MS/MS with subsequent multivariate statistical analysis, revealing distinctive host and microbial metabolome patterns between the C57J and the C57N strain. Many taurine-conjugated bile acids (TBAs) were significantly elevated in the cecum and decreased in liver samples from the C57J phenotype likely displaying different energy utilization behavior by the bacterial community and the host. Furthermore, several metabolite groups could specifically be associated with the C57N phenotype involving fatty acids, eicosanoids and urobilinoids. The mass differences based metabolite network approach enabled to extend the range of known metabolites to important bile acids (BAs) and novel taurine conjugates specific for both strains. In summary, our study showed clear alterations of the metabolome in the gastrointestinal tract and liver within a HFD-induced obesity mouse model in relation to the host-microbial nutritional adaptation.
Isolation and enzymic properties of levansucrase secreted by <i>Acetobacter diazotrophicus</i> SRT4, a bacterium associated with sugar cane (1995)

Acetobacter diazotrophicus, a nitrogen-fixing bacterium associated with sugar cane, secretes a levansucrase (sucrose-2,6-beta-D-fructan 6-beta-D-fructosyltransferase; EC 2.4.1.10). This enzyme is constitutively expressed and represents more than 70% of the total proteins secreted by strain SRT4. The purified protein consists of a single 58 kDa polypeptide with an isoelectric point of 5.5. Its activity is optimal at pH 5.0. It catalyses transfructosylation from sucrose to a variety of acceptors including water (sucrose hydrolysis), glucose (exchange reaction), fructan (polymerase reaction) and sucrose (oligofructoside synthesis). In vivo the polymerase activity leads to synthesis of a high-molecular-mass fructan of the levan type. A. diazotrophicus levansucrase catalyses transfructosylation via a Ping Pong mechanism involving the formation of a transient fructosyl-enzyme intermediate. The catalytic mechanism is very similar to that of Bacillus subtilis levansucrase. The kinetic parameters of the two enzymes are of the same order of magnitude. The main difference between the two enzyme specificities is the high yield of oligofructoside, particularly 1-kestotriose and kestotetraose, accumulated by A. diazotrophicus levansucrase during sucrose transformation. We discuss the hypothesis that these catalytic features may serve the different biological functions of each enzyme.
Copper-Catalyzed Annulation of 2-Formylazoles with <i>o</i>-Aminoiodoarenes (2010)

In the presence of catalytic CuI and sparteine, 2-formylpyrroles can be annulated with o-aminoiodoarenes to give substituted pyrrolo[1,2-a]quinoxalines and related heterocycles. The reaction also works for annulation of 2-formylindoles, 2-formylimidazole, 2-formylbenzimidazole, and a 3-formylpyrazole.
Bio‐assays of humic‐like model compounds: Chelation versus acid‐base effects (1989)

Abstract Solutions (5 × 10‐5 M) of humic‐like model compounds, chiefly, hydroxybenzoic and cinnamic acids, were tested for their ability to inhibit the growth of hydrilla (Hydrilla verticillata Royle). This is a perennial, adventitious plant that has the ability to occupy the top meter of water in sub‐tropical and temperate zones and eliminate benthic or rooted plants through shading. Humic acid and a naturally occurring soils extract have the ability to inhibit the growth of this plant (total organic carbon 0.4 mg/L), and the humic‐like models were tested for comparison. None appeared to be as effective as the natural product. Chelation does not appear to be the explanation for inhibition, though there was a good negative correlation between the degree of growth inhibition and the pKA of the model compound.
Mercury Adsorption by Sulfurized Fibrous Silicates (1991)

Abstract To eliminate mercury vapor from gas streams, three major methods are used: condensation, absorption, and adsorption. This work deals with adsorption, using elemental sulfur as an active phase supported on sepiolite and palygorskite fibrous clays. Sulfur loads of 5–30% were deposited by catalytic oxidation of hydrogen sulfide at temperatures of <200°C, the clays acting first as a catalyst of the reaction and then as a carrier of the obtained sulfur. The ability of the sulfurized clay adsorbents to retain mercury was studied at 45°C and 1 mm Hg pressure. The high values found, about 4 g Hg/g S supported on clays, compared with 1.69 g Hg/g S on activated carbon under the same conditions are related to a more appropriate pore size distribution, with more of the pore widths >6 nm for the sulfurized silicates. Also, the allotropic state of the deposited sulfur, where Sπ (octo-catena) is better than Sλ (octo-cycle), may also be a contributing factor.
Secondary ion mass spectrometry. Cationization of organic molecules with metals (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSecondary ion mass spectrometry. Cationization of organic molecules with metalsH. Grade and R. G. CooksCite this: J. Am. Chem. Soc. 1978, 100, 18, 5615–5621Publication Date (Print):August 1, 1978Publication History Published online1 May 2002Published inissue 1 August 1978https://pubs.acs.org/doi/10.1021/ja00486a006https://doi.org/10.1021/ja00486a006research-articleACS PublicationsRequest reuse permissionsArticle Views264Altmetric-Citations105LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ANALYSIS OF GO JEK E-SERVICE QUALITY AND ITS EFFECT ON CUSTOMER SATISFACTION IN JAMBI CITY (2018)

The development of technology is one of the supporting tools for companies capable of meeting the needs of consumers, by providing the best service. One technology-based business is GO Jek. GO jek is a company that leads the ojek transportation industry revolution that was pioneered since 2010. The technology-based Go Jek service or known as the quality of electronic services (E-service) provides convenience to customers through internet media. The research method is descriptive verification with multiple linear regression analysis tools. The number of samples used was 164 respondents. The results showed the simultaneous effect of variable e-service quality on consumer satisfaction of Go Jek in Jambi City. The dominant sub-variable influencing is an efficiency that is equal to 50.66%.
Use of Chromic Oxide as an Indicator of Fecal Output for the Purpose of Determining the Intake of Pasture Herbage by Grazing Cows (1955)

Summary A series of five trials was conducted to determine the adequacy of Cr 2 O 3 as an indicator of fecal output by grazing cows. Seventeen individual cows were employed in these studies. The Cr 2 O 3 concentration of feces taken reetally at 6 a.m. and 4 p.m. on seven consecutive days and bulked on an equal weight basis provided accurate estimates of the total fecal output. The mean rate of recovery of the ingested Cr 2 O 3 from the combined feces sampled at 6 a.m. and 4 p.m. was 100.58 ± 0.87%. A study of the Cr 2 O 3 concentration-time excretion patterns of grazing cows revealed that from 65 to 141% as much Cr 2 O 3 is voided in the feces at various hours of the day as is found in well-mixed feces representing the total amount of feces voided during a 7-day period. This precludes the indiscriminate adoption of times for the sampling of feces for the purpose of measuring the total output of feees by grazing cows. No difference in the accuracy of the estimated output of feces was found between the administration of Cr 2 O 3 , in capsules and that in concentrate feeds. Also, the effectiveness of the procedure for measuring fecal output was the same regardless of whether Cr 2 O 3 was administered at 6 a.m. or 4 p.m. or at 6 a.m. and 4 p.m. It is suggested that the time and mode of administration of Cr 2 O 3 employed in the conduct of grazing studies should be determined by the nature of the experiment and the convenience of the operation.
Editorial (1994)

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A new portrayal of electron and hole traps in amorphous silicon nitride (1990)

Trap centers in amorphous silicon nitride (a-SiNx) have been considered to be amphoteric. We found two signals of Si3 3/4 Si0 and N3 3/4 Si0 (Si dangling bonds with an unpaired electron) by an electron-spin-resonance method, and estimated the hole trap density to be larger than the electron trap density by about one decade, using the nonvolatile memory devices. As a result, we propose a new portrayal in which electron/hole traps are at the interface between Si clusters and a-SiNx bulk, and hole traps are at nitrogen vacancies in a-SiNx bulk.
Step-wise Approach to Permanent His Bundle Pacing (2016)

There has been a recent upsurge of interest in permanent His bundle pacing, given increased understanding and appreciation of the role dyssynchronous ventricular activation plays in congestive heart failure and atrial fibrillation. Permanent His bundle pacing gives implanters the ability to avoid causing ventricular dyssynchrony in patients dependent on ventricular pacing, and can provide an alternative means to implementing cardiac resynchronization therapy in patients with bundle branch disease and congestive heart failure. This paper describes a step-wise approach to implanting permanent His bundle pacing leads, with a clear demonstration of techniques and observations encountered during the course of typical His bundle lead implantations, including consideration of potential pitfalls and workarounds.
Contact dermatitis: clinics and pathology (2001)

Contact dermatitis or eczema is a polymorphic inflammation of the skin. It occurs at the site of contact with irritating or antigenic substances. In the acute phase there is occurrence of itching erythema, papules, and vesicles, whereas in the chronic phase there is dryness, hyperkeratosis, and sometimes fissures. Contact dermatitis can be divided into irritant and allergic types. Allergic contact dermatitis is a type-IV T-cell-mediated reaction occurring in a sensitized individual after contact with the antigen/allergen. Such antigens are usually low molecular weight substances (MW approximately 500), called haptens; 3000 contact allergens are known. The diagnosis of contact allergy is made on the basis of the history, clinical findings, and a positive epicutancous test result. Allergic, but not irritative, contact dermatitis can spread beyond the area of contact to other body parts. Eczematous lesions are characterized by a mononuclear infiltrate consisting mainly of T cells in the dermis and epidermis, together with an intercellular epidermal edema that is. spongiosis. In allergic contact dermatitis, skin-applied antigen is taken up by epidermal Langerhans cells and transported with the afferent lymph to the regional lymph nodes. Here, naive T lymphocytes are sensitized to become antigen-specific effector T cells, which then leave the lymph node, enter the circulation, and are recruited to the skin by means of specific cell surface molecules, to form the infiltrates. Cytokines released by infiltrating T cells eventually cause keratinocyte apoptosis.
Preparation of silk fibroin and polyallylamine composites (2002)

Abstract Composite films made of silk fibroin (SF) and polyallylamine (PAA) are prepared that contain various compositional ratios. These materials are analyzed to elucidate the resulting physical properties and to assess their potential toward advanced applications as industrial materials. The composite films are obtained from a SF and PAA binary system by dry casting from aqueous solution. These composite films exhibit excellent processability such as film forming capabilities, and the elongation at break is increased in the wet state. The differential scanning calorimetry (DSC) curves of the composites suggest that a mutual interaction takes place between the SF and PAA. This interaction is believed to occur because the endothermic peak, corresponding to the individual polymer, shifts with increasing SF content. The random coil conformation of the SF is present, regardless of the PAA blending, as confirmed by FTIR and DSC measurements. Additionally, living cells from Antheraea pernyi and Bombyx mori insect tissues are shown to grow effectively on the composite films. Maximum growth levels occur when the cultivation flask is coated with the material in SF/PAA ratios of 75:25 to 25:75. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 84: 1963–1970, 2002; DOI 10.1002/app.10491
Interleukin-10 promoter polymorphisms influence susceptibility to ulcerative colitis in a gender-specific manner (2008)

A gender effect is observed, with women of AG/AA IL10 genotypes and AC/AT haplotypes having a higher risk of developing UC at a younger age. This finding could be related to the previously documented lower IL10 production associated with the -1082A allele and to the IL10 down-regulating effect of estrogens.