gebhart/patrepeval huggingface dataset:
Solid Lubricating Films. Friction-Wear Improvement with Poly(benzonthiazole) Binders (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolid Lubricating Films. Friction-Wear Improvement with Poly(benzonthiazole) BindersBobby D. McConnellCite this: Ind. Eng. Chem. Prod. Res. Dev. 1970, 9, 4, 529–534Publication Date (Print):December 1, 1970Publication History Published online1 May 2002Published inissue 1 December 1970https://pubs.acs.org/doi/10.1021/i360036a013https://doi.org/10.1021/i360036a013research-articleACS PublicationsRequest reuse permissionsArticle Views59Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Matrix‐assisted laser desorption/ionization inside a quadrupole ion‐trap detector cell (1992)

Abstract An ion‐trap detector has been modified for matrix‐assisted laser desorption/ionization using a pulsed frequency‐quadrupled Nd: YAG laser and extended mass range up to 3300 u using the resonant‐rejection mode of operation. The matric‐assisted laser desorption/ionization mass spectra of a number of peptides are reported, and the effects due to the synchronization of the laser pulses and the phase of the RF voltage applied to the ring electrode are described.
Differential Mechanisms of Binding of Anti-Sigma Factors <i>Escherichia coli</i> Rsd and Bacteriophage T4 AsiA to <i>E. coli</i> RNA Polymerase Lead to Diverse Physiological Consequences (2008)

Anti-sigma factors Escherichia coli Rsd and bacteriophage T4 AsiA bind to the essential housekeeping sigma factor, sigma(70), of E. coli. Though both factors are known to interact with the C-terminal region of sigma(70), the physiological consequences of these interactions are very different. This study was undertaken for the purpose of deciphering the mechanisms by which E. coli Rsd and bacteriophage T4 AsiA inhibit or modulate the activity of E. coli RNA polymerase, which leads to the inhibition of E. coli cell growth to different amounts. It was found that AsiA is the more potent inhibitor of in vivo transcription and thus causes higher inhibition of E. coli cell growth. Measurements of affinity constants by surface plasmon resonance experiments showed that Rsd and AsiA bind to sigma(70) with similar affinity. Data obtained from in vivo and in vitro binding experiments clearly demonstrated that the major difference between AsiA and Rsd is the ability of AsiA to form a stable ternary complex with RNA polymerase. The binding patterns of AsiA and Rsd with sigma(70) studied by using the yeast two-hybrid system revealed that region 4 of sigma(70) is involved in binding to both of these anti-sigma factors; however, Rsd interacts with other regions of sigma(70) as well. Taken together, these results suggest that the higher inhibition of E. coli growth by AsiA expression is probably due to the ability of the AsiA protein to trap the holoenzyme RNA polymerase rather than its higher binding affinity to sigma(70).
Multidimensional Preference Query Optimization on Infrastructure Monitoring Systems (2019)

Performance monitoring systems collect and analyze data, and provide insight on availability, performance, and capacity from various monitored targets. However, the analytics in online performance monitoring systems have often been limited due to the query performance of large-scale multidimensional data. The existing approaches for preference or ranking queries generally include approaches with and without pre-processing. The approaches without pre-processing work well with small data sets. For larger datasets, the preference query is usually slow or not time feasible. In this paper, we introduce and evaluate an optimized query approach for performance monitoring systems using the bit-sliced index (BSI). The objective is to enable users to perform fast interactive queries with various querying criteria on multiple dimensions. The experiments cover preference top-k queries on the proposed approach with BSI, an approach using bitmap indexing for top-k queries, and the sequential scan sort top-k selection algorithms. The evaluation covers the single attribute query, multiple attributes weighted sum query, and multidimensional grouping using a real-time performance monitoring system data with several hundred thousand records. Working with a single attribute top-k evaluation, the proposed bit-sliced approach on average outperforms the bitmap approach and the sequential scan approach by a factor of 2 and a factor of 100+ respectively. Similarly, with multiple attributes sum top-k evaluation, it is 5 times faster than the sequential scan approach as well.
The Ammonium Nitrate‐Potassium Nitrate System (1981)

Abstract A portion of the binary phase diagram for the system ammonium nitrate‐potassium nitrate has been determined from − 55 °C to 185 °C. Results are presented for the ammonium‐nitrate‐rich end of the system up to 30 wt% potassium nitrate.
Current accumulation for a self magnetic field calculation in a finite-element gun code (2005)

We describe a novel current accumulation algorithm for the three-dimensional self magnetic field calculation in a charged-particle beam optics code. The current source is a charged-particle beam represented by a collection of numerically-integrated current-carrying rays. We compute the magnetic vector potential using edge basis functions and the curl-curl formulation of the finite-element method. The current accumulation algorithm takes advantage of a novel particle tracker that happens to be ideal for this application. We show that our source vector is compatible with the singular finite-element matrix, even with modest numerical integration errors. Thus, a conjugate gradient matrix solver works well, with no need for additional gauge conditions. We confirmed this behavior in a series of numerical tests on a small problem with incomplete linear and quadratic basis functions on a variety of element shapes.
New Titles: Cancer: The Outlaw Cell Second Edition (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew Titles: Cancer: The Outlaw Cell Second EditionRichard LaFondCite this: J. Phys. Chem. 1989, 93, 2, 1009Publication Date (Print):January 1, 1989Publication History Published online8 January 2004Published inissue 1 January 1989https://pubs.acs.org/doi/10.1021/j100339a601https://doi.org/10.1021/j100339a601research-articleACS PublicationsRequest reuse permissionsArticle Views20Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Can pretreatment CT predict local control of T2 glottic carcinomas treated with radiation therapy alone? (1995)

Like low-volume supraglottic and T3 glottic carcinomas, T2 glottic squamous cell carcinoma is likely (82%) to be controlled with definitive radiation therapy. Failure to control the primary tumor is attributable to factors other than volume, which may not be detectable on CT, such as tumor-host biological factors. Pretreatment CT, however, is beneficial for detecting submucosal spread across the ventricle and subglottic extension, which might contraindicate vertical hemilaryngectomy and might not be apparent on endoscopic examination.
A Study of Nitrogen Incorporation during the Oxidation of Si(100) in  N 2 O  at High Temperatures (1996)

The oxidation of Si(100) in N2O has been studied at temperatures in the range from 950 to 1200°C using secondary ion mass spectroscopy, Auger electron spectroscopy, and x-ray photoelectron spectroscopy. During oxidation N became incorporated into the oxide film, the amount increasing with increasing temperature to 1100°C and then falling to a lower value at 1200°C. The N was concentrated as a thin N-rich layer near the SiO2-Si interface inhibiting the influx of oxidant, leading to a reduction in the extent of oxidation compared with that in pure O2. The oxidant species is believed to be NO, which is stable under the conditions of the experiments. The N-rich phase was shown to have a composition of Si3N4 surmounted by N-rich oxynitride.
Synthesis and Evaluation of Imidazolylmethylenetetrahydronaphthalenes and Imidazolylmethyleneindanes:  Potent Inhibitors of Aldosterone Synthase (2004)

Elevated plasma aldosterone levels play a detrimental role in certain forms of congestive heart failure and myocardial fibrosis. We proposed aldosterone synthase (CYP11B2) as a novel target for the treatment of these diseases. In this study, the synthesis and biological evaluation of substituted E- and Z-imidazolylmethylenetetrahydronaphthalenes and E- and Z-imidazolylmethyleneindanes (compounds 1a,b-9a,b) is described. The compounds were prepared by a Wittig-like reaction. They were tested for activity using bovine CYP11B and human CYP11B2 expressed in fission yeast and V79 MZh cells. Selectivity was determined toward human CYP11B1, CYP19, and CYP17. Especially in the case of CYP11B1 (steroid 11beta-hydroxylase), selectivity is a crucial issue, since sequence homology between this enzyme and the target enzyme is very high (93%). On the basis of the X-ray structure of human CYP2C9, a protein model of CYP11B2 was developed and docking experiments with the title compounds were performed. The biological results revealed highly potent inhibitors of CYP11B2 (IC(50) = 4-93 nM). The Z-isomers usually were more active than the corresponding E-isomers. Different inhibitory profiles could be observed: rather selective inhibitors of CYP11B1, dual inhibitors of both enzymes, and rather selective inhibitors of CYP11B2. The chloro derivative 8b was found to be a highly potent CYP11B2 inhibitor (IC(50) = 4 nM) showing a 5-fold selectivity for CYP11B1 (IC(50) = 20 nM). This compound could be an interesting lead for further optimization as a therapeutic agent. It also could be used as well as the CYP11B1 selective compounds as a pharmacological tool.
PER and EVM Measurements of a Radio-Over-Fiber Network for Cellular and WLAN System Applications (2004)

This paper investigates the transmission characteristics of an optical signal that is modulated by a radio-frequency signal using an electroabsorption modulator (EAM). The transmission performances of the radio-over-fiber (ROF) system were evaluated at cellular bands of 900 MHz, 1.8 GHz, 1.9 GHz, and 2.1 GHz and at ISM bands of 2.4 GHz and 5.8 GHz for wireless local area network and intelligent transportation systems applications. Error vector magnitude (EVM) and packet error rate (PER) measurements were carried out to evaluate the performance. Bias voltages of the EAM and bias currents of a distributed feedback laser diode were varied for the evaluation of the optical power measurements.
The Observation of Highly Ordered Domains in Membranes with Cholesterol (2013)

Rafts, or functional domains, are transient nano- or mesoscopic structures in the exoplasmic leaflet of the plasma membrane, and are thought to be essential for many cellular processes. Using neutron diffraction and computer modelling, we present evidence for the existence of highly ordered lipid domains in the cholesterol-rich (32.5 mol%) liquid-ordered ([Formula: see text]) phase of dipalmitoylphosphatidylcholine membranes. The liquid ordered phase in one-component lipid membranes has previously been thought to be a homogeneous phase. The presence of highly ordered lipid domains embedded in a disordered lipid matrix implies non-uniform distribution of cholesterol between the two phases. The experimental results are in excellent agreement with recent computer simulations of DPPC/cholesterol complexes [Meinhardt, Vink and Schmid (2013). Proc Natl Acad Sci USA 110(12): 4476-4481], which reported the existence of nanometer size [Formula: see text] domains in a liquid disordered lipid environment.
Cytoprotection by omega-3 fatty acids as a therapeutic drug vehicle when combined with nephrotoxic drugs in an intravenous emulsion: Effects on intraglomerular mesangial cells (2014)

During therapeutic interventions, blood concentrations of intravenously applied drugs are higher, and their onset of pharmacological action is faster than with other routes of drug administration. However, acute drug therapy often produces nephrotoxic side effects, as commonly seen after treatment with Ketorolac or Gentamicin leading to questions about their use, especially for patients at risk for acute renal failure. Omega-6(n-6) and omega-3(n-3) polyunsaturated fatty acids (PUFA) affect eicosanoid metabolism, which plays a role in the regulation of inflammation. Eicosanoids derived from n-6 FA have proinflammatory and immunoactive functions, whereas eicosanoids derived from n-3 PUFA have anti-inflammatory and cytoprotective properties. We hypothesized that providing such injectable drugs with nephrotoxic potential in combination with n3-PUFAs from the outset, might afford rapid cytoprotection of renal cells, given the recent evidence that intravenously administered n3-PUFAs are rapidly incorporated into cell membranes. We used intraglomerular mesangial cells (MES13) that are sensitive to treatment with Ketorolac or Gentamicin instead of proximal tubular cells which do not respond to Ketorolac. We found a significant inhibition of Ketorolac (0.25, 0.5, 1 mM) or Gentamicin (2.5, 5 mM) induced cytotoxicity after pretreatment of MES13 cells with 0.01% of 20%w/v LipOmega-3 Emulsion 9/1, containing 90:10 wt/wt mixture of fish oil derived triglycerides to medium chain triglycerides.
A Research Agenda for Service-Oriented Architecture (SOA): Maintenance and Evolution of Service-Oriented Systems (2010)

Despite recent reports that it has failed, the reality is that Service-Oriented Architecture (SOA) remains the best option available for systems integration and leverage of legacy systems. The technologies to implement SOA will certainly evolve to address emerging needs, but its concepts will remain. To address those needs and concerns that SOA is potentially being stretched beyond its limits, a significant and coordinated research program is needed. The SEI has developed an SOA Research Agenda with participation from a broad cross-section of the research community. The core of the agenda is a taxonomy that classifies topics into the business, engineering, and operations aspects of service-oriented systems, along with a set of cross-cutting aspects. Based on this taxonomy, the agenda outlines research areas, each of which is identified with its rationale, overview of current research, and delineation of research challenges and gaps. This report outlines the SOA Research Agenda. It also provides detail on specific research challenges related to the maintenance and evolution of service-oriented systems. The report concludes with a discussion of next steps in the evolution of the research agenda.
Cultured endothelial cells synthesize both platelet-activating factor and prostacyclin in response to histamine, bradykinin, and adenosine triphosphate. (1985)

Cultured human endothelial cells synthesize prostacyclin (PGI2), a potent inhibitor of platelet function, when stimulated with histamine, bradykinin, or ATP. Paradoxically, we report that these agonists also induced the rapid and sustained synthesis of platelet-activating factor (PAF) by endothelial cells. In fact, the synthesis of this potent activator of platelets and neutrophils was induced by stimulation of the same receptor subtype that induced PGI2 synthesis: stimulation of a histamine H1 or a bradykinin B2 receptor induced both PAF and PGI2 synthesis. However, two physiologically important differences exist between the production of PAF and PGI2 by endothelial cells. The synthesis of PGI2 proceeded for only 7.5 min before the abrupt termination of synthesis, whereas the synthesis of PAF was clearly detectable even 45 min after stimulation. Although maximal accumulation of PAF occurred after 10-15 min of stimulation, the prolonged synthesis resulted in the presence of PAF for up to 1 h after stimulation. Secondly, whereas PGI2 was released from the cell monolayer, PAF remained cell-associated without significant release to the external medium. Endothelial cell-generated PAF, therefore, does not function as a hormone. The prolonged association of this potent activator of platelets and neutrophils with endothelial cells may mediate some of the inflammatory properties of histamine and bradykinin. It may also be a factor in the formation of a thrombogenic vascular surface, an event suggested to play a primary role in the pathogenesis of thrombosis and atherosclerosis.
New Tools for Fracture Design Optimization (2004)

Abstract Designing an effective and optimum fracture treatment is a complex and time-consuming task, especially in the case of new fields where the number of unknown variables is much larger than the number of known variables. Even with growing field maturity, changes in the fracture design often tend to be marginal and do not lead to a drastic improvement in the fracture design manifested by the post fracture production. This is not say that even marginal treatments are economically unattractive. Fracturing even when done badly is still one of the most economically rewarding petroleum operations. What we are addressing is a much more advanced and refined approach to design where economic benefits can be doubled or tripled. One explanation for the absence of continuous improvement of fracture treatments is lack of the appropriate tools to perform a thorough data-mining task, which would lead to a definitive improvement in post fracture production benefits. The appropriate tools for this task are presented in this paper. Although these tools are commonly used in other industries, they are still relatively new to most petroleum engineers. This paper provides an introduction to the technology and procedures to mine large databases for hidden, but valuable underlying relationships. An included comprehensive case study presents the workflow of the data mining approach to fracture optimization. A combination of Neural Networks and Genetic Algorithms, both regarded as artificial intelligence tools, are first applied to the data. The Neural Network is trained on historic data and captures the relationship between a certain data set of input parameters and the corresponding output parameter. This relationship is stored in the architecture of the Neural Network. In a following step, the Neural Network is used by the Genetic Algorithm optimization tool to calculate the optimum values for the various input parameters: in this case to maximize the output – the production after fracture treatment. Genetic algorithms are inspired by Darwin's law for the survival of the fittest. For the particular case the fittest values for the different parameter are those, which generate a high post fracture production. The results are than verified with the Unified Fracture Design approach. Neural Networks use historic data to train. It is required that the data show significant variation to capture the relationships between input and output. Data sets, which show too low variation in production (mainly on the poor side), cannot be optimized based on the artificial intelligence approach. For this case data mining results are integrated into the Unified Fracture Design approach, which will point to the optimum design. The combination of data mining with an appropriate fracture optimization design approach is a powerful combination in production engineering and one assured to provide large incremental economic benefits to the industry.
Dietary supplementation of old mice with flavonoid dihydroquercetin causes recovery of the mitochondrial enzyme activities in skeletal muscles (2009)

The effect of a potent antioxidant, flavonoid dihydroquercetin on the activity of three mitochondrial enzymes in mouse skeletal muscles has been investigated. An ability of this substance to restore the activity of mitochondrial enzymes in old animals was demonstrated. The activities of citrate synthase, NADHcoenzymeQ1-oxidoreductase (complex 1) and cytochromc-oxidase (complex 4) were assessed using spectro-photometric analysis in a quadriceps muscle homogenate. It was shown that the citrate synthase activity decreased moderately and the activities of complexes 1 and 4 in skeletal muscles dropped significantly in old mice. Supplementation of drink water with dihydroquercetin for a few weeks led to an increase of citrate synthase and complex 1 activity (P < 0.1) in muscles of old animals. Activity of complex 4 returned to the level found in the tissue of young mice. Maximal activity of citrate synthase and complex 1 was found in muscles of young mice. Sensitivity of NADH-coenzymeQ1-oxidoreductase to a specific inhibitor rotenone differed in all three groups of mice. Young and old mice exhibited about 95% and 84% of the total sensitivity, respectively, while in old mice receiving dihydroquercetin the sensitivity of complex 1 to the inhibitor increased up to 98%. The biochemical alterations entailed an increase in animals’ mobility as well as an improvement of fur and skin condition. Fatty acid composition of homogenate in muscle tissue of all three groups was also investigated. A reliable decline of the amount of linoleic acid and an increase in stearic and docosanoic acid contents as well as an increase of total amount of fatty acids in muscles of old mice were found. Statistically significant changes in fatty acid composition in muscles of old mice in the control group and in old mice receiving antioxidant were not observed.
Mitochondrial Topoisomerase I (Top1mt) Is a Novel Limiting Factor of Doxorubicin Cardiotoxicity (2014)

Our results provide evidence that Top1mt, which is conserved across vertebrates, is critical for cardiac tolerance to doxorubicin and adaptive response to doxorubicin cardiotoxicity. They also suggest the potential of Top1mt single-nucleotide polymorphisms testing to investigate patient susceptibility to doxorubicin-induced cardiotoxicity.