gebhart/patrepeval huggingface dataset:
Stable Expression of a Truncated AT1A Receptor in CHO-K1 Cells (1995)

Phosphorylation of serine and threonine residues in the carboxyl-terminal region of many G-protein-coupled receptors directs the rapid uncoupling from signal transduction pathways. In Chinese hamster ovary cells, we have stably expressed a truncated mutant of the angiotensin II (AT1A) receptor devoid of the carboxyl-terminal 45 amino acids, encompassing 13 serine/threonine residues. One clone, designated TL314 to indicate truncation after leucine 314, expressed a single class of angiotensin II receptors with a dissociation constant of 1.08 nM and a receptor density of 560 fmol/mg of protein (approximately 75,000 receptors/cell). A nonhydrolyzable analog of GTP accelerated the angiotensin II-induced dissociation of [125I]angiotensin II from TL314 plasma membranes 3.6-fold, indicating G-protein coupling. In TL314 cells, angiotensin II stimulated the release of intracellular calcium and the induction of mitogen-activated protein kinase activity, the level of which were comparable with the full-length AT1A receptor. The AII-stimulated calcium response was rapidly desensitized in both full-length and truncated AT1A receptors. Interestingly, angiotensin II-induced endocytosis of the truncated receptor was almost completely inhibited, suggesting that a recognition motif within the carboxyl-terminal 45 amino acids of the AT1A receptor promotes sequestration. Thus, truncation of the AT1A receptor after leucine 314 inhibits agonist-induced internalization without affecting the capacity of the expressed protein to adopt the correct conformation necessary for high affinity binding of angiotensin II, coupling to G-proteins, and activation of signal transduction pathways. The rapid desensitization and refractoriness of the angiotensin II-induced calcium transient in the TL314 cell line, in which putative carboxyl-terminal phosphorylation sites are absent, suggests that the mechanism of AT1A receptor desensitization differs from that of other prototypical G-protein-coupled receptors.
Milk Production and Reproductive Performance of Cows Hormonally Induced into Lactation (1975)

Eleven cows and five heifers were induced to lactate by the administration of 17 /3-estradiol and progesterone for 7 days followed by dexamethasone on days 18 to 20. Subsequent milk production varied from two animals which produced over 30 kg/day (approximately equal to previous production) to two animals which failed to lactate (<1 kg/day). Of the animals, 69% produced over 9 kg milk/day at peak yield. Although peak milk production was not reached until an average of 8.8 wk following commencement of milking, both peak production and production for days 2 to 8 were related closely to 305-day production. Reproductive status was monitored in 11 of the more successful cows. Ovaries of all animals were regressed by treatment, with first estrus occurring an average of 43 days following the last estrogen-progesterone injection. Nine cows were bred, and five conceived with no complications during pregnancy. Since all animals were culled from the University herd for reproductive problems, this method to induce lactation offers promise as a procedure to return problem breeders of good genetic quality to production.
Mitochondrial Microheteroplasmy and a Theory of Aging and Age-Related Disease (2005)

We implicate a recently described form of mitochondrial mutation, mitochondrial microheteroplasmy, as a candidate for the principal component of aging. Microheteroplasmy is the presence of hundreds of independent mutations in one organism, with each mutation usually found in 1-2% of all mitochondrial genomes. Despite the low abundance of single mutations, the vast majority of mitochondrial genomes in all adults are mutated. This mutational burden includes inherited mutations, de novo germline mutations, as well as somatic mutations acquired either during early embryonic development or later in adult life. We postulate that microheteroplasmy is sufficient to explain the pathomechanism of several age-associated diseases, especially in conditions with known mitochondrial involvement, such as diabetes (DM), cardiovascular disease, Parkinson's disease (PD), and Alzheimer's disease (AD) and cancer. The genetic properties of microheteroplasmy reconcile the results of disease models (cybrids, hypermutable PolG variants and mitochondrial toxins), with the relatively low levels of maternal inheritance in the aforementioned diseases, and provide an explanation of their delayed, progressive course.
Variability of natural gas composition in select major metropolitan areas of the United States. Interim report, August 1990-March 1991 (1991)

The interim report quantifies potential regional and seasonal variations in the composition and physical properties of natural gas in selected major urban areas of the United States over a one-year time period. Major urban areas were chosen because they represent a large segment of existing gas consumers and are envisioned to be a key market area for natural gas vehicles. The report lists the results of statistical analyses of gas composition in ten U.S. nonattainment cities for either ozone or carbon monoxide levels. The data are intended to provide a strong statistical basis for understanding the chemical and physical properties of natural gas in support of engine and vehicle manufacturers making equipment design and development decisions as well as related R D initiatives on gas-fired reciprocating engine technology and vehicle refueling and storage. Additional program work is underway to expand the data base to represent a total of 25 major urban areas.
Update on the Management of Keloids (2009)

Keloids are scars, unique to humans, that grow beyond the boundaries of a cutaneous injury, inflammation, burn, or surgical incision. Although benign, keloids are often aesthetically malignant. The etiology of keloids is uncertain. However, we do know that they occur more often in African-American and Asian than Caucasian patients. There is no one therapeutic modality that either prevents the formation of keloids or treats active or inactive lesions. Consequently, there are many therapeutic options. In this review, an approach to medical and surgical management of keloids is provided, as well as a review of experimental therapeutic modalities.
Anomaly Intrusion Detection Approach Using Hybrid MLP/CNN Neural Network (2006)

An anomaly intrusion detection approach based on hybrid MLP/CNN (multi-layer perceptron/chaotic neural network) neural network is proposed in this paper. Most anomaly detection approaches using MLP can detect novel real-time attacks, but still has high false alarm rates. Most attacks are composed of a series of anomaly events. These attacks are called time-delayed attacks, which current neural network IDSs (intrusion detection system) cannot identify efficiently. A hybrid MLP/CNN neural network is constructed in order to improve the detection rate of time-delayed attacks. While obtaining a similarly detection rate of real-time attacks as the MLP does, the proposed approach can detect time-delayed attacks efficiently with chaotic neuron. This approach also exhibits a lower false alarm rate when detects novel attacks. The simulation tests are conducted using DARPA 1998 dataset. The experimental results are presented and compared in ROC curves, which can demonstrate that the proposed approach performs exceptionally in terms of both detection rate and false alarm rate
Amino acid and peptide transport systems. (2009)

This review covers transporter theory, biochemically characterized amino acid and peptide transport systems, molecular characterization of transport proteins, and characterization of gastrointestinal tract amino acid and peptide transporters in farm animals (chickens, pigs, sheep and cattle).
High-Yield Synthesis of Mesoscopic Conductive and Dispersible Carbon Nanostructures via Ultrasonication of Commercial Precursors (2014)

The need to produce large quantities of graphenic materials displaying excellent conductivity, thermal resistance, and tunable properties for industrial applications has spurred interest in new techniques for exfoliating graphite. In this paper, sonication-assisted exfoliation of graphitic precursors in the presence of chloroform is shown to produce chemically and structurally unique exfoliated graphitic materials in high yields. These exfoliated graphites, referred to as mesographite and mesographene, respectively, exhibit unique properties which depend on the number of layers and exfoliation conditions. Structural characterization of mesographene reveals the presence of nanoscale two-dimensional graphene layers, and three-dimensional carbon nanostructures sandwiched between layers, similar to those found in ball-milled and intercalated graphites. The conductivities of mesographite and mesographene are 2700 and 2000 S/m, respectively, indicating high conductivity despite flake damage. Optical absorption measurements of mesographite sonicated in various solvents showed significant changes in dispersion characteristics, and also indicated significant changes to mesoscopic colloidal behavior. A mechanism for functionalization and formation of capped carbon nanostructures is proposed by integrating the chemical and structural characterization in relation to the various carbon structures observed by electron microscopy. Composites based on common polymers were prepared by solution processing, and changes in thermal properties indicate improved dispersion of mesographite in polar polymers.
Extraction of Heart Rate Variability from Smartphone Photoplethysmograms (2015)

Heart rate variability (HRV) is a useful clinical tool for autonomic function assessment and cardiovascular diseases diagnosis. It is traditionally calculated from a dedicated medical electrocardiograph (ECG). In this paper, we demonstrate that HRV can also be extracted from photoplethysmograms (PPG) obtained by the camera of a smartphone. Sixteen HRV parameters, including time-domain, frequency-domain, and nonlinear parameters, were calculated from PPG captured by a smartphone for 30 healthy subjects and were compared with those derived from ECG. The statistical results showed that 14 parameters (AVNN, SDNN, CV, RMSSD, SDSD, TP, VLF, LF, HF, LF/HF, nLF, nHF, SD1, and SD2) from PPG were highly correlated (r > 0.7, P < 0.001) with those from ECG, and 7 parameters (AVNN, TP, VLF, LF, HF, nLF, and nHF) from PPG were in good agreement with those from ECG within the acceptable limits. In addition, five different algorithms to detect the characteristic points of PPG wave were also investigated: peak point (PP), valley point (VP), maximum first derivative (M1D), maximum second derivative (M2D), and tangent intersection (TI). The results showed that M2D and TI algorithms had the best performance. These results suggest that the smartphone might be used for HRV measurement.
The alpha-tubulin gene family expressed during cell differentiation in Naegleria gruberi. (1988)

Genes that direct the programmed synthesis of flagellar alpha-tubulin during the differentiation of Naegleria gruberi from amebae to flagellates have been cloned, and found to be novel with respect to gene organization, sequence, and conservation. The flagellar alpha-tubulin gene family is represented in the genome by about eight homologous DNA segments that are exceptionally similar and yet are neither identical nor arrayed in a short tandem repeat. The coding regions of three of these genes have been sequenced, two from cDNA clones and one from an intronless genomic gene. These three genes encode an identical alpha-tubulin that is conserved relative to the alpha-tubulins of other organisms except at the carboxyl terminus, where the protein is elongated by two residues and ends in a terminal glutamine instead of the canonical tyrosine. In spite of the protein conservation, the Naegleria DNA sequence has diverged markedly from the alpha-tubulin genes of other organisms, a counterexample to the idea that tubulin genes are conserved. alpha-Tubulin mRNA homologous to this gene family has not been detected in amebae. This mRNA increases markedly in abundance during the first hour of differentiation, and then decreases even more rapidly with a half-life of approximately 8 min. The abundance of physical alpha-tubulin mRNA rises and subsequently falls in parallel with the abundance of translatable flagellar tubulin mRNA and with the in vivo rate of flagellar tubulin synthesis, which indicates that flagellar tubulin synthesis is directly regulated by the relative rates of transcription and mRNA degradation.
American Depositary Receipts and Their Uses (1969)

(1969). American Depositary Receipts and Their Uses. Financial Analysts Journal: Vol. 25, No. 1, pp. 15-20.
Positive inotropic effect of 3, 4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)-qu inolinone (OPC-8212) in the dog with experimentally-induced right-sided heart failure. (1984)

The efficacy of orally active 3, 4-dihydro-6-[4-(3,4- dimethoxybenzoyl )-1-piperazinyl]-2(1H)- quin olinone ( OPC -8212) as a positive inotropic agent was examined using model right-sided heart failure dogs and compared with those of dobutamine and amrinone. Heart failure was produced in beagle dogs by a combination of tricuspid insufficiency and pulmonary stenosis, and then drugs were administered intravenously or orally. Intravenous OPC -8212, 1 and 3 mg/kg, amrinone, 1 and 3 mg/kg, and dobutamine, 0.01 and 0.03 mg/kg, increased the dP/dt of the right ventricular pressure for 5 to 10 min. These positive inotropic effects were accompanied by simultaneous increase in the heart rate in the cases of amrinone and dobutamine, and was accompanied by hypotension in the case of amrinone. However, OPC -8212 did not show such effects. This indicates that OPC -8212 has a relatively selective positive effect on cardiac contractility. Oral administration of OPC -8212, 10 to 100 mg/kg, and amrinone, 10 and 30 mg/kg, also showed a positive inotropic effect, appearing 1 h after administration and lasting up to the 5th h. Amrinone had about a 3 times stronger effect, but for similar positive inotropic effects, only amrinone showed positive chronotropic effect. The hypotensive effect of amrinone was also observed after oral administration, while such an effect was scarcely observed when using OPC -8212.
Knowing the Tropes: Literary Exegesis and Chaucer's Clerk (1985)

Those who know the tropes, however, wrote Saint Augustine in On Christian Doctrine, recognize in the sacred letters, and this knowledge will be of considerable assistance in understanding them (3.29.40). And a little further on: Yet the awareness of [the tropes] is necessary to a solution of the ambiguities of the Scrip tures, for when the sense is absurd if it is taken verbally, it is to be inquired whether or not what is said is expressed in this or that trope which we do not know; and in this way many hidden things are dis covered (3.29.41).1 Irony is one of the tropes Augustine mentions specifically. Augustine's position has been made to serve as an an chor for medieval theories of reading, especially since 1962 when D. W. Robertson's controversial A Preface to Chaucer2 asserted the dominance of Patristic thought over the discourse of the middle ages. Reading theory is a necessary part of any attempt to understand the relationship between medieval texts and the history which sur rounded their production. It is worth our asking, therefore, whether knowing the tropes as Augustine discusses leads to the conclu sions Robertson and Robertsonians have claimed. In order to focus
Circle of Willis Atherosclerosis Is a Risk Factor for Sporadic Alzheimer’s Disease (2003)

Our study reveals an association between severe circle of Willis atherosclerosis and sporadic AD that should be considered a risk factor for this dementia. These observations strongly suggest that atherosclerosis-induced brain hypoperfusion contributes to the clinical and pathological manifestations of AD.
Photodynamic inactivation of methicillin-resistant Staphylococcus aureus and Escherichia coli: A metalloporphyrin comparison (2016)

Increasing rates of antibiotic resistance coupled with the lack of novel antibiotics threatens proper clinical treatment and jeopardizes their use in prevention. A photodynamic approach appears to be an innovative treatment option, even for multi-drug resistant strains of bacteria. Three components are utilized in photodynamic inactivation: a photosensitizer, light source, and oxygen. Variations in photosensitizers strongly influence microbial binding and bactericidal activity. In this study, four different cationic metalloporphyrins (Cu<sup>2+</sup>, Fe<sup>2+</sup>, Pd<sup>2+</sup>, Zn<sup>2+</sup>) were compared to the free-base ligand 5,10,15,20-tetrakis(N-methylpyridinium-4-yl)porphyrin regarding their electronic properties and generation of reactive oxygen species upon subsequent 405nm violet-blue irradiation. Staphylococcus aureus and Escherichia coli were used as representatives of Gram-positive and -negative, respectively, to assess bactericidal effects by the photodynamic process. Bacterial cultures were pre-incubated with porphyrins and exposed to varying doses of 405nm irradiation (0-30J/cm<sup>2</sup>). Metalloporphyrins containing Cu<sup>2+</sup> and Fe<sup>2+</sup> demonstrated minimal effects on viability. Pronounced bactericidal activity was evident with free-base ligand, Zn<sup>2+</sup>, and Pd<sup>2+</sup>; though significantly stronger effects were apparent with Pd<sup>2+</sup>. Photodynamic killing was directly proportional to reactive oxygen species production post-illumination. These data provide new insight into the influence of metal chelation on photosensitizer activity on bactericidal singlet oxygen production. The strong anti-microbial photodynamic action through the use of a portable light-emitting diode over short time intervals (seconds) provides support for its potential use in self-treatment.
Infrared Patch-Image Model for Small Target Detection in a Single Image (2013)

The robust detection of small targets is one of the key techniques in infrared search and tracking applications. A novel small target detection method in a single infrared image is proposed in this paper. Initially, the traditional infrared image model is generalized to a new infrared patch-image model using local patch construction. Then, because of the non-local self-correlation property of the infrared background image, based on the new model small target detection is formulated as an optimization problem of recovering low-rank and sparse matrices, which is effectively solved using stable principle component pursuit. Finally, a simple adaptive segmentation method is used to segment the target image and the segmentation result can be refined by post-processing. Extensive synthetic and real data experiments show that under different clutter backgrounds the proposed method not only works more stably for different target sizes and signal-to-clutter ratio values, but also has better detection performance compared with conventional baseline methods.
A 20 GHz MMIC power module for transmit phased array applications (2002)

A novel high gain, high power, high efficiency and high linearity MMIC power module is developed for a 20 GHz transmit phased array for future communication satellite application. This MMIC module has a maximum gain of 50 dB, a gain range more than 30 dB, an output power of 1.1 Watt, an efficiency of 18% and a third-order Intermodulation of 17 dBc at 19 GHz. It has a size of 4.5/spl times/1.75/spl times/0.5", a mass of 100 gm and a DC power consumption of 6.3 Watt.
Langmuir-Blodgett-Kuhn Multilayers of Polyglutamates with Azobenzene Moieties: Investigations of Photoinduced Changes in the Optical Properties and Structure of the Films (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLangmuir-Blodgett-Kuhn Multilayers of Polyglutamates with Azobenzene Moieties: Investigations of Photoinduced Changes in the Optical Properties and Structure of the FilmsMichael Buechel, Zouheir Sekkat, Stefan Paul, Birgit Weichart, Henning Menzel, and Wolfgang KnollCite this: Langmuir 1995, 11, 11, 4460–4466Publication Date (Print):November 1, 1995Publication History Published online1 May 2002Published inissue 1 November 1995https://pubs.acs.org/doi/10.1021/la00011a046https://doi.org/10.1021/la00011a046research-articleACS PublicationsRequest reuse permissionsArticle Views123Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Molecular Dynamics Simulations of Hexahydro-1,3,5-trinitro-1,3,5-<i>s</i>-triazine (RDX) Using a Combined Sorescu−Rice−Thompson AMBER Force Field (2006)

We present the results of molecular dynamics simulations of crystalline hexahydro-1,3,5-trinitro-1,3,5-s-triazine (RDX) using the SRT-AMBER force field (P. M. Agrawal et al., J. Phys. Chem. B 2006, 110, 5721), which combines the rigid-molecule force field developed by Sorescu-Rice-Thompson (D. C. Sorescu, B. M. Rice, and D. L. Thompson, J. Phys. Chem. B 1997, 101, 798) with the intramolecular interactions obtained from the Generalized AMBER Force Field (Wang et al., J. Comput. Chem. 2004, 25, 1157). The calculated crystal density at room conditions is about 10% lower than the measured value, while the lattice parameters and thermodynamic melting point are within about 5% at ambient pressure. The chair and inverted chair conformation, bond lengths, and bond angles of the RDX molecule are accurately predicted; however, there are some inaccuracies in the calculated orientations of the NO2 groups. The SRT-AMBER force field predicts overall reasonable results, but modifications, probably in the torsional parameters, are needed for a more accurate force field.
Role of Plasminogen Activator Inhibitor Type 1 in the Pathogenesis of Coronary Artery Diseases (1994)

Patients with ischaemic heart disease have high levels of plasminogen activator inhibitor type 1 (PAI-1). These levels can constitute an independent thrombotic risk factor. In addition, PAI-1 synthesis is greater in the atherosclerotic vessels than in the normal vessels and this can also constitute an atherogenic risk factor. There is a good correlation between insulinaemia and PAI-1, but it has not been demonstrated that the circulating level of PAI-1 depends exclusively on insulinaemia. The increased levels of PAI-1 correlate with other coronary risk factors, especially hypertriglyceridaemia, but high PAI-1 levels are also found in normolipaemic patients. Vascular synthesis of PAI-1 can be promoted by high levels of circulating lipoprotein a. Finally, an exercise programme can increase the fibrinolytic activity of heart disease patients towards normal.