gebhart/patrepeval huggingface dataset:
Noise attenuation methods for point‐receiver land seismic data (2010)

Data quality from onshore seismic acquisition can be challenging because of near‐surface complexity combined with the high amplitude of source‐generated noise. The very large channel count of modern acquisition systems enables sampling the source‐generated noise. In this paper, we focus on one of the very first processing steps, attenuating the source‐generated noise by digitizing the signal recorded by every individual sensor: point‐receiver data. We outline the principles of three algorithms for noise attenuation in point‐receiver data and we apply them to two onshore datasets acquired in very different conditions: permafrost and desert. The data examples clearly demonstrate the effectiveness of the coherent noise attenuation combined with excellent signal preservation.
REVIEWS SEDAINE: Le Philosophe sans le savoir. Edited by RODMELLGRAHAM E.. (Durham Modern Languages Series). University of Durham, 1987. 122 PP. £4.95. (1989)

REVIEWS Get access SEDAINE: Le Philosophe sans le savoir. Edited by GRAHAM E. RODMELL. (Durham Modern Languages Series). University of Durham, 1987. 122 PP. £4.95. W. D. HOWRATH W. D. HOWRATH BRISTOL Search for other works by this author on: Oxford Academic Google Scholar French Studies, Volume XLIII, Issue 3, July 1989, Pages 331–332, https://doi.org/10.1093/fs/XLIII.3.331 Published: 01 July 1989
How to Replace the Lost keys? Strategies Toward Safer K <sub>V</sub> 7 Channel Openers (2019)

The highly structurally similar drugs flupirtine and retigabine have been regarded as safe and effective for many years but lately they turned out to exert intolerable side effects. While the twin molecules share the mode of action, both stabilize the open state of voltage-gated potassium channels, the form and severity of adverse effects is different. The analgesic flupirtine caused drug-induced liver injury in rare but fatal cases, whereas prolonged use of the antiepileptic retigabine led to blue tissue discoloration. Because the adverse effects seem unrelated to the mode of action, it is likely, that both drugs that occupied important therapeutic niches, could be replaced. Reasons for the clinically relevant toxicity will be clarified and future substitutes for these drugs presented in this review.
Cytokine expression in squamous intraepithelial lesions of the uterine cervix: implications for the generation of local immunosuppression (1998)

We have addressed the notion that the progression of cancer of the uterine cervix is associated with a preferential constraint on the development of a type 1 cellular mediated response, which is necessary to efficiently eliminate (pre)neoplastic cells. Based on the importance of cytokines in the regulation of an appropriate immune response, we have evaluated the expression of IL-12p40, IL-10 and transforming growth factor-beta 1 (TGF-beta1). Using reverse transcriptase-polymerase chain reaction (RT-PCR), the expression of these three cytokines was evaluated in both low-grade (LG) and high-grade (HG) cervical squamous intraepithelial lesions (SIL) and in normal exocervix and transformation zone biopsies. Our results show that the average level of IL-12 increases within both the LG and HG SIL, compared with both control groups. Interestingly, the percentage of HG SIL expressing IL-12p40 was lower compared with LG SIL. In contrast, the expression of IL-10 increased in parallel with the severity of the lesion to a maximal level in HG SIL. Using immunohistochemistry, we ascertained the presence of IL-12 protein in SIL and IL-10 protein in the transformation zone and SIL biopsies. Both IL-12- and IL-10-producing cells were localized in the stroma, not within the SIL. Furthermore, in this study we also observed that the region of the cervix the most sensitive to lesion development, the transformation zone, was associated with higher average levels of the immunosuppressive cytokines IL-10 and TGF-beta1.
Hela Cells Consist of Two Cell Types, as Evidenced by Cytochemical Staining for Alkaline Phosphatase Activity: A Possible Model for Cancer Stem Cell Study (2013)

Alkaline phosphatase (ALP) is known to be expressed in the several somatic stem cells and cancer cells. To investigate whether ALP may be a promising marker for cancer stem cells (CSCs), we examined the expression of ALP in human squamous cell carcinoma HeLa cells using a cytochemical Advances in Stem Cells 2 staining kit. We found that approximately 40% of HeLa cells were positive for ALP activity. A single cell-derived colony assay revealed that the newly formed colonies could be classified into uniformly (U, 23%), mosaically (M, 17%), and non-stained (N, 60%) colonies. Each colony was picked and cultured for 2 additional weeks for cell propagation; the cells were either M-(45%) or N-type (55%), suggesting that the U-type colonies may have spontaneously changed to M-type colonies during cultivation. These resulting M-or N-type cells were stable with respect to ALP activity. DNA microarray analysis revealed that the gene expression pattern of N-type cells is almost identical to that of their parental HeLa cells (comprising M-type cells), but several genes including ALP gene were upregulated in the HeLa cells. Cultivation of single HeLa cell-derived colonies in the presence of the small molecule 6-bromoindirubin-3'-oxime (BIO), a potent inhibitor of glycogen synthase kinase 3 (GSK3), caused a reduction in the ratio of M-type colonies, suggesting that the transition from U-to M-type colonies is regulated by the Wnt/-catenin signaling pathway. Although there is no evidence, at present, that the ALP-positive cells are CSCs, future investigation may reveal that HeLa cells may be a good model for CSC study.
A simple technique to accurately determine intra-abdominal pressure (1987)

The determination of intra-abdominal pressure (IAP) may be useful in a variety of clinical situations. Despite this, invasive IAP monitoring is seldom performed due to the risks involved. Using a standard canine model of increased IAP, we evaluated the accuracy of transurethral bladder catheter pressure in reflecting IAP. Throughout the range of IAP studied (10 +/- 5 to 70 +/- 10 mm Hg), bladder pressure did not differ significantly from the direct measurement of IAP. We conclude that the measurement of bladder pressure using a standard transurethral bladder catheter provides an accurate determination of IAP.
Genome resequencing reveals multiscale geographic structure and extensive linkage disequilibrium in the forest tree<i>Populus trichocarpa</i> (2012)

• Plant population genomics informs evolutionary biology, breeding, conservation and bioenergy feedstock development. For example, the detection of reliable phenotype-genotype associations and molecular signatures of selection requires a detailed knowledge about genome-wide patterns of allele frequency variation, linkage disequilibrium and recombination. • We resequenced 16 genomes of the model tree Populus trichocarpa and genotyped 120 trees from 10 subpopulations using 29,213 single-nucleotide polymorphisms. • Significant geographic differentiation was present at multiple spatial scales, and range-wide latitudinal allele frequency gradients were strikingly common across the genome. The decay of linkage disequilibrium with physical distance was slower than expected from previous studies in Populus, with r(2) dropping below 0.2 within 3-6 kb. Consistent with this, estimates of recent effective population size from linkage disequilibrium (N(e) ≈ 4000-6000) were remarkably low relative to the large census sizes of P. trichocarpa stands. Fine-scale rates of recombination varied widely across the genome, but were largely predictable on the basis of DNA sequence and methylation features. • Our results suggest that genetic drift has played a significant role in the recent evolutionary history of P. trichocarpa. Most importantly, the extensive linkage disequilibrium detected suggests that genome-wide association studies and genomic selection in undomesticated populations may be more feasible in Populus than previously assumed.
Analysis of risk factors for uric acid nephrolithiasis in type 2 diabetes. (2011)

Type 2 diabetes mellitus (T2DM) is an independent risk factor for uric acid nephrolithiasis, and obesity augments this risk. We carried out this cross-sectional study on 25 patients of T2DM to assess the risk factors for uric acid nephrolithiasis and to assess their relation with components of the metabolic syndrome. A single 24-hour urine sample was analyzed for fasting urine pH, uric acid, creatinine and protein. Fasting serum sample was analyzed for HbA1c, glucose, creatinine, uric acid and lipid profile. Patients with past history of nephrolithiasis and significant hepatic or renal disease were excluded. The mean age of the participants was 51 ± 8.5 years and there were 16 females and nine males. Mean body mass index (BMI) was 27.3 ± 4.3 kg/m 2 and waist circumference was 90.8 ± 7.8 cm. Urinalysis revealed mean uric acid excretion of 595 ± 103 mg/24 hours and fasting urine pH of 5.6 ± 0.4. Fasting urine pH correlated inversely with the body weight, BMI and low density lipoprotein (LDL)-cholesterol (P < 0.05). Total volume showed inverse correlation with age and disease duration and correlated positively with body weight and BMI. Uric acid excretion did not correlate with the components of metabolic syndrome. Our preliminary data showed that low urine pH as the main risk factor for uric acid nephrolithiasis was consistently found in our study patients with T2DM. Higher BMI further accentuates this risk. Further data from more number of patients are necessary to confirm these findings.
The expression of SOCS is altered in rheumatoid arthritis (2007)

SOCS expression levels are profoundly altered in RA, and the profile of SOCS expression is dependent on both the cell type as well as the cellular compartment.
Display of Heterologous Proteins on <i>gp64</i> null Baculovirus Virions and Enhanced Budding Mediated by a Vesicular Stomatitis Virus G-Stem Construct (2007)

The Autographa californica multicapsid nucleopolyhedrovirus (AcMNPV) GP64 envelope glycoprotein is essential for virus entry and plays an important role in virion budding. An AcMNPV construct that contains a deletion of the gp64 gene is unable to propagate infection from cell to cell, and this defect results from both a severe reduction in the production of budded virions and the absence of GP64 on virions. In the current study, we examined GP64 proteins containing N- and C-terminal truncations of the ectodomain and identified a minimal construct capable of targeting the truncated GP64 to budded virions. The minimal budding and targeting construct of GP64 contained 38 amino acids from the mature N terminus of the GP64 ectodomain and 52 amino acids from the C terminus of GP64. Because the vesicular stomatitis virus (VSV) G protein was previously found to rescue infectivity of a gp64null AcMNPV, we also examined a small C-terminal construct of the VSV G protein. We found that a construct containing 91 amino acids from the C terminus of VSV G (termed G-stem) was capable of rescuing AcMNPV gp64null virion budding to wild-type (wt) or nearly wt levels. We also examined the display of chimeric proteins on the gp64null AcMNPV virion. By generating viruses that expressed chimeric influenza virus hemagglutinin (HA) proteins containing the GP64 targeting domain and coinfecting those viruses with a virus expressing the G-stem construct, we demonstrated enhanced display of the HA protein on gp64null AcMNPV budded virions. The combined use of gp64null virions, VSV G-stem-enhanced budding, and GP64 domains for targeting heterologous proteins to virions should be valuable for biotechnological applications ranging from targeted transduction of mammalian cells to vaccine production.
Glutamate Released by Dendritic Cells as a Novel Modulator of T Cell Activation (2006)

Adaptive immune responses begin after productive immunosynaptic contacts formation established in secondary lymphoid organs by dendritic cells (DC) presenting the Ag to T lymphocytes. Despite its resemblance to the neurosynapse, the participation of soluble small nonpeptidic mediators in the intercellular cross-talk taking place during T cell-DC interactions remains poorly studied. In this study, we show that human DC undergoing maturation and in contact with T cells release significant amounts of glutamate, which is the main excitatory neurotransmitter in mammalians. The release of glutamate is nonvesicular and mediated by the DC-expressed Xc- cystine/glutamate antiporter. DC-derived glutamate stimulating the constitutively expressed metabotropic glutamate receptor 5 impairs T cell activation. However, after productive Ag presentation, metabotropic glutamate receptor 1 is expressed in T cells to mediate enhanced T cell proliferation and secretion of Th1 and proinflammatory cytokines. These data suggest that, during T cell-DC interaction, glutamate is a novel and highly effective regulator in the initiation of T cell-mediated immune responses.
New Amorphous Mg-Ce-Ni Alloys with High Strength and Good Ductility (1988)

New Mg-based amorphous alloys with high strength and good ductility were produced in the Mg-Ce-Ni system by melt spinning. The tensile fracture strength ( σ f ) and Vickers hardness reach 750 MPa and 199 DPN for Mg 80 Ce 10 Ni 10 . The specific strength defined by the ratio of σ f to density is as high as 27, being considerably higher than the highest value (≃20) for conventional Al-based alloys. The high-strength Mg-base amorphous alloys are expected to attract much attention as a new type of high-strength material with low density.
A numerical study of rain-induced surface gravity wave attenuation. (1989)

Strong rain-induced mixing in a thin surface layer is numerically shown to greatly increase surface gravity wave attenuation. This case study uses a single wavelength (2.8 m) together with two mixed layer depths (10 and 20 cm). The rain-induced mixing is simulated by varying kinematic viscosity within the mixed layer from 10"* to 10"^ m- r*' , molecular to strong turbulent mixing, respectively. The results indicate that surface gravity wave attenuation in the presence of a thin rain-induced mixed layer can increase by a factor of up to 60U0 times the attenuation rate due to molecular viscosity alone. This indicates that rain need only mix the top 10-20 cm surface layer to effectively dampen short surface gravity waves.
Optical testing of printed circuit boards (2003)

An optical technique is described to test large printed circuit boards (PCBs) supporting surface-mounted components. This testing process is based on the change of the light polarization inside an electrooptic material plate. An anisotropic elastomer conductor particular to each type of PCB connects it to the electrooptical material. In a few seconds, high-frequency (100-MHz) signals with a spatial resolution of 1/1000-in. may be tested.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Reactions of low-coordinate transition-metal amides with secondary phosphanes and arsanes: synthesis, structural, and spectroscopic studies of [M{N(SiMe3)2}(.mu.-PMes2)]2 (M = manganese, iron), [Mn{N(SiMe3)2}(.mu.-AsMes2)]2 and Mes2AsAsMes2 (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions of low-coordinate transition-metal amides with secondary phosphanes and arsanes: synthesis, structural, and spectroscopic studies of [M{N(SiMe3)2}(.mu.-PMes2)]2 (M = manganese, iron), [Mn{N(SiMe3)2}(.mu.-AsMes2)]2 and Mes2AsAsMes2Hong Chen, Marilyn M. Olmstead, Doris C. Pestana, and Philip P. PowerCite this: Inorg. Chem. 1991, 30, 8, 1783–1787Publication Date (Print):April 1, 1991Publication History Published online1 May 2002Published inissue 1 April 1991https://pubs.acs.org/doi/10.1021/ic00008a020https://doi.org/10.1021/ic00008a020research-articleACS PublicationsRequest reuse permissionsArticle Views342Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Software visualization in the desert environment (1998)

While software visualization has been widely used for navigation, its use for understanding has been much more limited. Software visualizations are expensive to develop, require large amounts of information that is often difficult to collect, and even then, are good only at addressing the specific task for which they were developed. Our work on software visualization in the Desert environment is aimed at making software visualization a viable approach to understanding. We do this by providing ready access to a variety of information about the system at hand, a range of high-quality, high-density visualizations, and a simple interface that lets the programmer rapidly create new software visualizations for understanding problems as they arise. In this paper we describe the approach we have taken.
On RD optimized progressive image coding using JPEG (1999)

Among the many different modes of operations allowed in the current JPEG standard, the sequential and progressive modes are the most widely used. While the sequential JPEG mode yields essentially the same level of compression performance for most encoder implementations, the performance of progressive JPEG depends highly upon the designed encoder structure. This is due to the flexibility the standard leaves open in designing progressive JPEG encoders. In this work, a rate-distortion (RD) optimized JPEG compliant progressive encoder is presented that produces a sequence of scans, ordered in terms of decreasing importance. Our encoder outperforms an optimized sequential JPEG encoder in terms of compression efficiency, substantially at low and high bit rates. Moreover, unlike existing JPEG compliant encoders, our encoder can achieve precise rate/distortion control. Substantially better compression performance and precise rate control, provided by our progressive JPEG compliant encoding algorithm, are two highly desired features currently sought for the emerging JPEG-2000 standard.
Multi-Phase Series Resonant DC-to-DC Converters: Stationary Investigations (2006)

This paper investigates multi-phase series resonant DC-to-DC converters during stationary operation. The principle working of the converter is described in detail for switching frequencies equal to the resonant frequency. Design rules for all components are derived analytically. Additionally, the converter's advantages and disadvantages are discussed and the different topologies are compared with each other. Based on these design rules, a 5 kW/100 kHz laboratory prototype of a three-phase topology has been built. The prototype is used to verify the analysis experimentally
Ribosomal Protein L19 Is a Prognostic Marker for Human Prostate Cancer (2006)

Microquantity differential display analysis of gene expression profiles between benign (PNT2) and malignant (PC3M) human prostate cell lines identified the gene encoding ribosomal protein L19 (RPL19) to be overexpressed in the malignant cells. Northern blot hybridization analysis done on a wide range of human cell lines and tissues confirmed the level of RPL19 mRNA to be 5-fold higher in malignant cell lines and 8-fold higher in malignant tissues, when compared with their benign counterparts. Analysis of RPL19 mRNA expression by in situ hybridization revealed a significant increase of RPL19 expression in a substantial number of prostate cancers. All of the eight normal prostatic tissues were unstained (100%). Of 32 benign prostatic hyperplasia (BPH) tissues, 15 (46.9%) were unstained, 9 (28.1%) stained weakly, and 8 (25%) stained moderately. Among 87 carcinomas, only 7 (8.1%) were unstained, whereas 22 (25.2%) stained weakly, 21 (24.1%) stained moderately, and 37 (42.61%) stained strongly. The intensity of staining of the malignant specimens was significantly higher than that of normal and BPH specimens (chi(2): n = 127, P < 0.001). Gleason scores of the carcinomas correlated with RPL19 expression (chi(2): n = 87, P < 0.001). Kaplan-Meier survival analysis confirmed increased RPL19 expression to be highly predictive of shorter patient survival (P < 0.05), revealing RPL19 to be a sensitive predictor of prostate cancer progression. Expression of this protein could be a valuable marker in prostate cancer diagnosis and patient management.
The Brilliance, Sparkliness and Fire of Some Modifications to the Round Brilliant Cut Diamond Style (1978)

Abstract Small diamonds are often cut in the round brilliant style (RBCD) of 58 facets. Their small size (∼2 mm in diameter) militates against ease of handling and manufacture. The simplifications of the RBCD are discussed, and modifications to the basic design are shown to fall into four classes. Using a computer programme that equates the brilliance, sparkliness and fire of the stone to statistical properties of its scattered light distribution, several of the simplifications and some classes of modification are investigated. Simple trends in the measures of optical goodness become apparent, the main conclusion being that stones with more than eight crown and pavilion facets are acceptable, but inferior, substitutes for the 58-facet RBCD, especially for small stones.
Influence of Copper Morphology in Forming Nucleation Seeds for Graphene Growth (2011)

We report that highly crystalline graphene can be obtained from well-controlled surface morphology of the copper substrate. Flat copper surface was prepared by using a chemical mechanical polishing method. At early growth stage, the density of graphene nucleation seeds from polished Cu film was much lower and the domain sizes of graphene flakes were larger than those from unpolished Cu film. At later growth stage, these domains were stitched together to form monolayer graphene, where the orientation of each domain crystal was unexpectedly not much different from each other. We also found that grain boundaries and intentionally formed scratched area play an important role for nucleation seeds. Although the best monolayer graphene was grown from polished Cu with a low sheet resistance of 260 Ω/sq, a small portion of multilayers were also formed near the impurity particles or locally protruded parts.