gebhart/patrepeval huggingface dataset:
CR3 (Mac-1, alpha M beta 2, CD11b/CD18) and Fc gamma RIII cooperate in generation of a neutrophil respiratory burst: requirement for Fc gamma RIII and tyrosine phosphorylation. (1994)

Cooperation among plasma membrane receptors in activating signal transduction cascades is not well understood. For almost 20 years, it has been clear that when a particulate foreign body is opsonized with complement as well as IgG, the efficiency of IgG effector functions is markedly enhanced. However, the molecular mechanisms involved in cooperation between IgG Fc receptors and complement receptors have not been elucidated. In this work, we show that when human neutrophils (PMN) are plated on a surface coated with both anti-CR3 and anti-Fc gamma RIII antibodies, the respiratory burst which occurs is equivalent to that stimulated by anti-Fc gamma RII. The CR3 ligand iC3b is as effective as anti-CR3 for cooperating with anti-Fc gamma RIII in generation of a respiratory burst. The synergy between CR3 and Fc gamma RIII for activating the NADPH oxidase is abolished by Fab of anti-Fc gamma RII. Nonetheless, the observed synergy is not an artifact of unintended Fc gamma RII ligation, since (a) only this combination of antibodies works to generate H2O2; (b) coating plates with either of the antibodies alone cannot activate the respiratory burst at any dose; (c) LAD (CR3 deficient) cells, which are perfectly competent to mount a respiratory burst when Fc gamma RII is engaged, are incapable of activating the respiratory burst when adherent to wells coated with anti-Fc gamma RIII and anti-CR3; (d) direct engagement of Fc gamma RII activates the respiratory burst by a pathway pharmacologically distinguishable from the synergistic respiratory burst. Fc gamma RIII/CR3 synergy is abolished by cytochalasin B and herbimicin, suggesting that both the actin cytoskeleton and tyrosine phosphorylation are necessary for activation of the synergistic respiratory burst. Further analysis shows that CR3 and Fc gamma RIII have distinct roles in activation of this Fc gamma RII-dependent assembly of the NADPH oxidase. Ligation of CR3 is sufficient to lead to Fc gamma RII association with the actin cytoskeleton on the adherent PMN surface. Coligation of Fc gamma RIII is required for tyrosine phosphorylation of Fc gamma RII. These data are consistent with a model in which phosphorylation of Fc gamma RII or a closely associated substrate initiates activation of a signal transduction pathway leading to oxidase assembly. These are the first data to demonstrate a molecular mechanism for synergy between IgG Fc and complement receptors in activation of phagocyte effector functions.
MEAN VALUE MODELING OF A VARIABLE NOZZLE TURBOCHARGER (VNT) (2010)

Studiul abordeaza modelarea numerica a unui turbocompresor cu geometrie variabila, destinat reglarii in industria automobilelor. Accentul este pus pe modelarea curgerii gazului prin compresor si turbina, respectiv pe eficienţa izentropica aferenta. Modelele examinate sunt modele de regresie fizice, calibrate cu ajutorul unor diagrame furnizate de catre producatorul turbocompresorului. The paper offers an insight into the modeling of a variable nozzle turbocharger for automotive control applications. The emphasis is put on modeling the gas flows through the compressor and turbine and the corresponding isentropic efficiencies. The examined models are physically based regression models calibrated using the static maps provided by the turbocharger manufacturer.
Studies on retinal neovascularization. Friedenwald Lecture. (1980)

Evidence supporting the original concept of Michaelson and Ashton of a vasoproliferative or angiogenesis factor responsible for retinal neovascularization is discussed. The oxygen model of retinal neovascularization is described as a key example in this evidence. Newer studies on experimental retinal neovascularization and its control are summarized.
Testing and defects of bubble memory devices (1979)

A computer-controlled bubble memory wafer test system has been developed and more than 5,000 chips of 83 kbit and 300 kbit major-minor loop design have been tested. Throughout the testing, various types of defects have been found, including defects sensitive to bubble population, start-stop operation and in-plane holding field. These defects are found to be caused by small defects in permalloy patterns or garnet films. An effective way to detect these defects has been developed.
Insulin Resistance in Obesity as the Underlying Cause for the Metabolic Syndrome (2010)

The metabolic syndrome affects more than a third of the US population, predisposing to the development of type 2 diabetes and cardiovascular disease. The 2009 consensus statement from the International Diabetes Federation, American Heart Association, World Heart Federation, International Atherosclerosis Society, International Association for the Study of Obesity, and the National Heart, Lung, and Blood Institute defines the metabolic syndrome as 3 of the following elements: abdominal obesity, elevated blood pressure, elevated triglycerides, low high-density lipoprotein cholesterol, and hyperglycemia. Many factors contribute to this syndrome, including decreased physical activity, genetic predisposition, chronic inflammation, free fatty acids, and mitochondrial dysfunction. Insulin resistance appears to be the common link between these elements, obesity and the metabolic syndrome. In normal circumstances, insulin stimulates glucose uptake into skeletal muscle, inhibits hepatic gluconeogenesis, and decreases adipose-tissue lipolysis and hepatic production of very-low-density lipoproteins. Insulin signaling in the brain decreases appetite and prevents glucose production by the liver through neuronal signals from the hypothalamus. Insulin resistance, in contrast, leads to the release of free fatty acids from adipose tissue, increased hepatic production of very-low-density lipoproteins and decreased high-density lipoproteins. Increased production of free fatty acids, inflammatory cytokines, and adipokines and mitochondrial dysfunction contribute to impaired insulin signaling, decreased skeletal muscle glucose uptake, increased hepatic gluconeogenesis, and β cell dysfunction, leading to hyperglycemia. In addition, insulin resistance leads to the development of hypertension by impairing vasodilation induced by nitric oxide. In this review, we discuss normal insulin signaling and the mechanisms by which insulin resistance contributes to the development of the metabolic syndrome.
Correlation of Entropy with Similarity and Symmetry (1996)

Informational entropy is quantitatively related to similarity and symmetry. Some tacit assumptions regarding their correlation have been shown to be wrong. The Gibbs paradox statement (indistinguishability corresponds to minimum entropy, which is zero) has been rejected. All their correlations are based on the relation that less information content corresponds to more entropy. Higher value of entropy is correlated to higher molecular similarity. The maximum entropy of any system (e.g., a mixture or an assemblage) corresponds to indistinguishability (total loss of information), to perfect symmetry or highest symmetry, and to the highest simplicity. This conforms without exception to all the experimental facts of both dynamic systems and static structures and the related information loss processes.
Unified lossless and near-lossless color image coding based on adaptive quantization (2002)

This paper proposes a unified coding algorithm for lossless and near-lossless compression of still color images. The algorithm can control the Peak Signal-to-Noise Ratio (PSNR) of the reconstructed image. Furthermore, the distortion on the RGB plane is suppressed to within the level of /spl plusmn/p, where p is a certain small non-negative integer. In order to control the PSNR of the reconstructed image, an adaptive quantizer is designed on the basis of human visual criteria. Experimental results confirm the effectiveness of the proposed algorithm.
Safe Sequential Path Planning of Multi-Vehicle Systems Under Presence of Disturbances and Imperfect Information. (2016)

Recently, there has been an immense surge of interest in using unmanned aerial vehicles (UAVs) for civil purposes. Multi-UAV systems are safety-critical, and safety guarantees must be made to ensure no undesirable configurations such as collisions occur. Hamilton-Jacobi (HJ) reachability is ideal for analyzing such safety-critical systems because it provides safety guarantees and is flexible in terms of system dynamics; however, its direct application is limited to small-scale systems of no more than two vehicles because of the exponential-scaling computation complexity. By assigning vehicle priorities, the sequential path planning (SPP) method allows multi-vehicle path planning to be done with a computation complexity that scales linearly with the number of vehicles. Previously the SPP method assumed no disturbances in the vehicle dynamics, and that every vehicle has perfect knowledge of the position of higher-priority vehicles. In this paper, we make SPP more practical by providing three different methods for accounting for disturbances in dynamics and imperfect knowledge of higher-priority vehicles. Each method has advantages and disadvantages with different assumptions about information sharing. We demonstrate our proposed methods in simulations.
버라이어티쇼 방송 시청정도와 여가태도의 관계 (2011)

이 연구는 버라이어티쇼 방송 시청정도와 대학생의 여가태도의 관계를 규명하는 데 그 목적이 있다. 조사도구는 설문지로 일반적 특성 4문항과 시청정도 3문항과 여가태도의 하위요인인 인지적 영역, 정의적 영역, 행동적 영역 16문항 등 전체 23문항을 사용하였다. 각 항목의 응답은 Likert Scale 5점 척도로 사용하였다. 표집방법은 경기지역 Y대학 재학생을 모집단으로 설정한 후, 판단표본 추출법을 이용하여 추출하였다. 설문 표집된 168명의 자료를 SPSS WIN 18.0의 프로그램을 이용하여 전산처리 하였다. 자료분석은 빈도분석, 요인분석, 신뢰도분석, 독립 t-검증, 일원변량분석, 상관분석, 다중회귀분석을 실시하였다. 통계적 유의수준은 p<.05 수준이다. 결과는 다음과 같다. 첫째, 대학생의 인구사회학적 특성에 따라 시청정도는 성별, 학년별, 생활정도에 따라 유의한 차이가 나타나지 않았다. 학과에 따라서는 비체육 전공자가 높게 나타났다. 둘째, 대학생의 인구사회학적 특성에 따라 여자가 인지적 영역에 있어 유의한 차이가 나타났다. 학년에 있어서 인지적 영역, 정의적 영역은 4학년이 타 집단과 유의한 차이가 있는 것으로 나타났다. 학과에 있어서 인지적 영역이 비체육전공자와 유의한 차이가 있는 것으로 나타났다. 생활정도는 인지적 영역이 중 집단에서 유의한 차이가 있는 것으로 나타났다. 셋째, 대학생의 버라이어티쇼 방송프로그램 시청정도가 여가태도에 미치는 영향에 있어 인지적 영역, 행동적 영역에 시청횟수 만 부(－)의 영향을 미치는 것으로 나타났다. 시청정도는 정의적 영역에 있어서 영향을 미치지 않는 것으로 나타났다.
Heterogeneous position of the double bonds of unsaturated fatty acids in carotenoid glucoside esters from Rhodococcus rhodochrous RNMS1. (1990)

Rhodococcus rhodochrous RNMS1 has been found to contain four kinds of carotenoid pigments.1) The major one was fatty acid esters of a carotenoid glucoside, and their structure was 1 '-[(6-0-acyl-/?-D-glucopyranosyl)oxy]-r^-dihydro-jft^-caroten^-one.
The acoustic behavior of the fish-catching bat, <i>N</i> <i>o</i> <i>c</i> <i>t</i> <i>i</i> <i>l</i> <i>i</i> <i>o</i> <i>l</i> <i>e</i> <i>p</i> <i>o</i> <i>r</i> <i>i</i> <i>n</i> <i>u</i> <i>s</i>, during prey capture (1989)

Many bats change the acoustic parameters of their echolocation calls in a deliberate manner during prey capture. Attempts to quantify these changes have been either of limited scope or subject to potentially severe errors due to an inadequate consideration of the directionality of both the bat and the recording microphone. Therefore, the echolocation pulses emitted by two N. leporinus have been recorded as they approached and captured stationary prey, with the microphone positioned in such a way that the structure of the pulses incident upon the target could be determined. The results of this study show that: (1) during the last 1.5 m of the approach, N. leporinus reduces the intensity of emitted pulses by 6 dB per halving of distance, so that the intensity incident upon the target is constant; (2) at a point in the pulse train that corresponds to the position of the hypothesized tracking phase of echolocation, N. leporinus selectively reduces the intensity of the frequency-modulated (FM) fundamental so that the FM pulse component is predominantly second harmonic; and (3) a high degree of temporal overlap occurs between the FM component of emitted pulse and echo when N. leporinus is within 0.4 m of its prey.
Carbon dioxide removal from anaesthetic gas circuits using absorbent membrane contactors (2009)

Tese de doutoramento. Engenharia Química e Biológica. Faculdade de Engenharia. Universidade do Porto. 2009
Photochemical Coatings for the Prevention of Bacterial Colonization (1991)

Biomaterials are being used with increasing frequency for tissue substitution. Implantable, prosthetic devices are instrumental in the saving of patients' lives and enhancing the quality of life for many others. However, the greatest barrier to expanding the use of biomedical devices is the high probability of bacterial adherence and proliferation, causing very difficult and often untreatable medical-device centered infections. The difficulty in treating such infections results in great danger to the patient, and usually retrieval of the device with considerable pain and suffering. Clearly, development of processes that make biomedical devices resistant to bacterial adherence and colonization would have widespread application in the field of biomedical technology. A photochemical surface modification process is being investigated as a generic means of applying antimicrobial coatings to biomedical devices. The photochemical process results in covalent immobilization of coatings to all classes of medical device polymers. A discussion of the photochemical surface modification process and preliminary results demonstrating the success of photochemical coatings in formulating microbial-resistant surfaces are presented in this paper.
Autonomous Real-Time Navigation for Service Level Agreement in Distributed Information Service System (2007)

In today's aggressive and competitive marketplace, there is substantial need for corporations to incorporate service level agreement (SLA) in their enterprise; and keep user differentiation with respect to information volume, response time, or system availability; to make their business more idiosyncratic. Faded information field (FIF) was proposed to deliver assurance in distributed information system but it does not fulfil requirement of user differentiation to attain heterogeneous service levels. Due to structural characteristics of FIF, SLA-based mobile agent navigation technology is proposed, which is composed of autonomous node, response time monitoring, local status notification between neighbor nodes, and finally the Pull-MA navigation decision based on locality statistics information. As a result, the requests are able to avoid local congestion zones without a centralized dispatcher or workload manager, leading to globally accomplishing the heterogeneous service level objectives of each user even in case of subsystem failure and ever-changing environment. The effectiveness of the proposed technology has been proved through simulation, and the results show that the navigation technology increases an average of 60% the service satisfaction ratio. Since proposed navigation of Pull-MA is highly dependent on value of maximum access time (MAT), MAT per node was simulated for different techniques. Moreover, response time of all nodes in the network was simulated and satisfaction ratio for various possible techniques, along with that proposed has been shown for comparison
A three-dimensional neural recording array (2002)

The authors describe a three-dimensional recording array for the high-density monitoring of neural activity throughout a volume of cortical tissue. The microassembly techniques used permit multiple multishank planar probes to be precisely configured to form 3D microstructures with probe spacings of 100 mu m or less. The probes are aligned through an orthogonal platform, also formed by silicon micromachining. High-density lead transfers between the probes and the platform are formed by selective electroplating and offer very low values of series resistance and shunt capacitance, with center-to-center lead spacings of 100 mu m or less. A 4*4 shank passive probe array has been found to penetrate pia arachnoid easily and is well accepted by the neural tissue. These assembly techniques also appear to be compatible with a variety of other microelectromechanical systems where 3D structures are required.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
CAR T-Cell Cancer Therapy Targeting Surface Cancer/Testis Antigens (2020)

OPINION article Front. Immunol., 02 September 2020Sec. Cancer Immunity and Immunotherapy Volume 11 - 2020 | https://doi.org/10.3389/fimmu.2020.01568
Colonization of Host Plants by the Fire Blight Pathogen <i>Erwinia amylovora</i> Marked with Genes for Bioluminescence and Fluorescence (1998)

ABSTRACT To follow the movement of Erwinia amylovora in plant tissue without dissection, this bacterium was marked with either the lux operon from Vibrio fischeri or the gfp gene from the jellyfish Aequorea victoria, both carried on multicopy plasmids and expressed under the control of the lac promoter from Escherichia coli. Movement of the pathogen was visualized in leaves, stems, and roots of apple seedlings, and migration of E. amylovora was traced from inoculation sites in the stem to as far as the roots. Green fluorescent E. amylovora cells were observed in the xylem and later appeared to break out of the vessels into the intercellular spaces of the adjacent parenchyma. Inoculation in the intercostal region of leaves caused a zone of slow necrosis that finally resulted in bacterial invasion of the xylem vessels. Labeled bacteria could also be seen in association with the anchor sites of leaf hairs. Distortion of the epidermis adjacent to leaf hairs created openings that were observed by scanning electron microscopy. As the intercostal region, the bases of leaf hairs provided E. amylovora access to intact xylem vessels, which allowed further distribution of the pathogen in the host plant.
Selective monoesterification of dicarboxylic acids catalysed by ion-exchange resins (1999)

Symmetrical dicarboxylic acids with 4–14 carbon atoms gave selectively the corresponding monoesters in high yields in the transesterification catalysed by strongly acidic ion-exchange resins in ester–hydrocarbon mixtures. It was found that the rate of the esterification of the dicarboxylic acids is much higher than that of the monocarboxylic acids formed. This result can explain the high selectivity for the monoester formation and can also be explained by the existence of an aqueous layer on the surface of the resins. This method of selective esterification is quite simple and practical.
All-Optical Vector Atomic Magnetometer (2014)

We demonstrate an all-optical magnetometer capable of measuring the magnitude and direction of a magnetic field using nonlinear magneto-optical rotation in cesium vapor. Vector capability is added by effective modulation of the field along orthogonal axes and subsequent demodulation of the magnetic-resonance frequency. This modulation is provided by the ac Stark shift induced by circularly polarized laser beams. The sensor exhibits a demonstrated rms noise floor of ∼65 fT/√[Hz] in measurement of the field magnitude and 0.5 mrad/√[Hz] in the field direction; elimination of technical noise would improve these sensitivities to 12 fT/√[Hz] and 10 μrad/√[Hz], respectively. Applications for this all-optical vector magnetometer would include magnetically sensitive fundamental physics experiments, such as the search for a permanent electric dipole moment of the neutron.
The Use of Microcarrier-Roller Bottle Culture for Large-Scale Production of Porcine Hepatocytes (1997)

Microcarrier-attached hepatocytes have applications in both artificial liver support and cell transplantation therapies. In either scenario, maintenance of the cells' in vitro metabolic functions is of primary importance. We are reporting the potential to scale up production and enhance detoxification function of porcine hepatocytes for use in cell-based liver support systems, such as those currently in clinical trials. Previous studies of anchorage-dependent cells in vitro have suggested a correlation between tridimensional morphology and the maintenance of function. In this study, four different microcarrier-roller bottle cultures of porcine hepatocytes were compared for their influence on aggregate formation, benzodiazepine metabolism, and cell proliferation. Porcine hepatocytes were seeded on microcarriers at cell density normalized to surface area by adjustment of bead number (6.25 cm2/1 × 106 cells) and maintained in roller bottle culture for 6 days. Microcarrier sizes ranged from 90 to 1000 µm. Mean diazepam metabolic production ranged from 18 to 31 µg/1 × 106 cells. The highest diazepam metabolic activity and DNA content were measured on day 4 cultures. Ratios based on aggregate size (number of microcarriers per aggregate) were similar for most microcarriers, but the aggregation characteristics of surface-treated polystyrene (Biosilon) beads were higher. The increased cell contact and tissuelike structure observed in those cultures were reflected in improved cell proliferation, as measured by DNA content, but not in increased detoxification function, as evaluated by diazepam metabolite production. In conclusion, microcarrier-roller bottle culture of porcine hepatocytes allows large numbers of cells to be maintained with greater ease than in monolayers and enhances cell proliferation but, under these study conditions, did not improve individual cell function.
Automatically collecting, monitoring, and mining japanese weblogs (2004)

We present a system that tries to automatically collect and monitor Japanese blog collections that include not only ones made with blog softwares but also ones written as normal web pages. Our approach is based on extraction of date expressions and analysis of HTML documents. Our system also extracts and mines useful information from the collected blog pages.
Electrically conductive silicone nano-composites for stretchable RF devices (2011)

The objective of this paper is to show how stretchable conductive composites can be utilized for the fabrication of ultra-low cost stretchable RF devices. We show a method to produce biocompatible highly conductive stretchable silicone composites via an in-situ nanoparticle formation and sintering process. Furthermore, we develop a simple, low cost, processing technique to fabricate stretchable RF transmission lines. These RF transmission lines are highly flexible, stretchable and robust. The S-parameter measurements show stable performance during mechanical deformation up to 6 GHz. Future development of this technology will enable ultra low cost consumer RF devices serving as a platform for future stretchable electronic devices.
Injection mode locking of a multiatmosphere TE CO&lt;inf&gt;2&lt;/inf&gt;laser (1977)

A multiatmosphere TE CO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> laser operated at pressures up to 8 atm has been injection mode-locked. Peak single pulse energies of ∼1 J were obtained in a 1-ns pulse when the 70 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> device was operated at ∼8 atm.
A filter synthesis technique applied to the design of multistage broadband microwave amplifiers (2003)

A synthesis method for designing multistage broadband amplifiers based upon well known filter synthesis techniques is presented. Common low-pass approximations are used to synthesize the amplifier circuit. A proof of concept Butterworth low-pass two-stage amplifier was designed, simulated and measured, and achieved a flat gain performance of 1-4 GHz with a gain of 15 /spl plusmn/ 1 dB as predicted. A comparison is made with the distributed amplifier (DA) and the cascaded single stage distributed amplifier (CSSDA). Theoretically a larger gain bandwidth product is achieved using the synthesis technique.