gebhart/patrepeval huggingface dataset:
A dual-angle streaming ultramicroscope for submicrometre particle size measurement (1993)

Streaming ultramicroscopy is a potentially valuable technique for size analysis of submicrometre particles but suffers from a number of limitations. In particular, the need to observe light pulses scattered from the particles at small angles, in order to obtain a monotonic particle size-intensity relationship, leads to high background count rates from non-streaming particles in the incident beam. The author describes the use of a novel dual-angle coincidence technique, in which light pulses scattered at 90 degrees to the incident beam are used to gate the small-angle signal, thus rejecting pulses from particles not in the central particle stream. This arrangement has the advantages of high sensitivity and background rejection due to the perpendicular viewing arrangement, while retaining the monotonic size-intensity relationship up to a particle diameter of 2.3 mu m at a relative refractive index of 1.1. The author believes that this is a significant improvement in the design of single-particle optical size measurement instruments.
Activities of Ten Essential Oils towards Propionibacterium acnes and PC-3, A-549 and MCF-7 Cancer Cells (2010)

Ten essential oils, namely, mint (Mentha spicata L., Lamiaceae), ginger (Zingiber officinale Rosc., Zingiberaceae), lemon (Citrus limon Burm.f., Rutaceae), grapefruit (Citrus paradisi Macf., Rutaceae), jasmine (Jasminum grandiflora L., Oleaceae), lavender (Mill., Lamiaceae), chamomile (Matricaria chamomilla L., Compositae), thyme (Thymus vulgaris L., Lamiaceae), rose (Rosa damascena Mill., Rosaceae) and cinnamon (Cinnamomum zeylanicum N. Lauraceae) were tested for their antibacterial activities towards Propionibacterium acnes and in vitro toxicology against three human cancer cell lines. Thyme, cinnamon and rose essential oils exhibited the best antibacterial activities towards P. acnes, with inhibition diameters of 40 +/- 1.2 mm, 33.5 +/- 1.5 mm and 16.5 +/- 0.7 mm, and minimal inhibitory concentrations of 0.016% (v/v), 0.016% (v/v) and 0.031% (v/v), respectively. Time-kill dynamic procedures showed that thyme, cinnamon, rose, and lavender essential oils exhibited the strongest bactericidal activities at a concentration of 0.25% (v/v), and P. acnes was completely killed after 5 min. The thyme essential oil exhibited the strongest cytotoxicity towards three human cancer cells. Its inhibition concentration 50% (IC(50)) values on PC-3, A549 and MCF-7 tumor cell lines were 0.010% (v/v), 0.011% (v/v) and 0.030% (v/v), respectively. The cytotoxicity of 10 essential oils on human prostate carcinoma cell (PC-3) was significantly stronger than on human lung carcinoma (A549) and human breast cancer (MCF-7) cell lines.
Chemical Exfoliation of Vermiculite and the Production of Colloidal Dispersions (1967)

Chemical treatments involving ion exchange cause gross onedimensional swelling in water of single crystals of vermiculite minerals. A delicate balance of forces holds the individual silicate layers (10 angstroms thick) parallel to one another although separated by several hundred angstroms. Colloidal dispersions produced from the swollen crystals are morphologically unique and show strong filmforming characteristics.
The orally administered P-glycoprotein inhibitor R101933 does not alter the plasma pharmacokinetics of docetaxel. (2000)

This Phase I study was performed to assess the feasibility of combining docetaxel with the new P-glycoprotein inhibitor R101933 and to determine the dose limiting toxicity of this combination. Fifteen patients received oral R101933 alone at a dose escalated from 200 to 300 mg twice daily (b.i.d.; cycle 0), an escalating i.v. dose of docetaxel (60, 75, and 100 mg/m2) as a 1-h infusion (cycle 1), and the combination (cycle 2 and further). Dose limiting toxicity consisting of mucositis and neutropenic fever was reached at the combination of docetaxel, 100 mg/m2, and R101933, 300 mg b.i.d., and the maximum tolerated dose was established at docetaxel, 100 mg/m2, and R101933, 200 mg b.i.d. Plasma concentrations of R101933 achieved in patients were in the same range as required in preclinical rodent models to overcome paclitaxel resistance. The plasma pharmacokinetics of docetaxel were not influenced by the R101933 regimen at any dose level tested, as indicated by plasma clearance values of 26.5 +/- 7.78 liters/h/m2 and 23.4 +/- 4.52 liters/h/m2 (P = 0.15) in cycles 1 and 2, respectively. These findings indicate that the contribution of a P-glycoprotein inhibitor to the activity of anticancer chemotherapy can now be assessed in patients for the first time independent of its effect on drug pharmacokinetics.
Timing-aware power noise reduction in layout (2005)

In this paper, we propose a timing-aware power-noise reduction technique. Our approach consists of prediction and correction steps. Before placement, we estimate the power noise of each cell considering switching frequency of cells which, after placement, will most likely be in the neighborhood. If a frequently switching cell has neighbors which switch infrequently, it is unlikely that this cell will suffer from a power noise problem. Based on the cell power noise estimation, we add decap padding to each cell. Then we invoke a standard cell placement tool and perform power grid analysis. We eliminate the power grid noise by gate sizing. Our technique can reallocate decaps to improve power noise, power consumption, and timing. The gate sizing is based on the sequence of linear programs (SLP) formulation, and it can be solved efficiently. Experimental results show that our techniques can effectively reduce power noise and meet timing constraints.
Gelatin/chondroitin sulfate nanofibrous scaffolds for stimulation of wound healing: <i>In‐vitro</i> and <i>in‐vivo</i> study (2016)

In this research, fabrication of gelatin/chondroitin sulfate (GAG) nanofibrous scaffolds using electrospinning technique for skin tissue engineering was studied. The influence of GAG content on chemical, physical, mechanical and biological properties of the scaffolds were investigated. Human dermal fibroblast (HDF) cells were cultured and bioactivity of electrospun gelatin/GAG scaffolds for skin tissue engineering was assayed. Biological results illustrated that HDF cells attached and spread well on gelatin/GAG nanofibrous scaffolds displaying spindle-like shapes and stretching. MTS assay was performed to evaluate the cell proliferation on electrospun gelatin/GAG scaffolds. The results confirmed the influence of GAG content as well as the nanofibrous structure on cell proliferation and attachment of substrates. The gelatin/GAG nanofibrous scaffolds with the desired thickness for in-vivo evaluations were used on the full-thickness wounds. Pathobiological results showed that cell loaded gelatin/GAG scaffolds significantly accelerated wounds healing. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 2020-2034, 2017.
Ion Trajectory Simulations in a High-Pressure Cylindrical Ion Trap (2010)

We present the simulation of a cylindrical ion trap (CIT) at high pressure (5-25 Torr range). SIMION 7.0 software was used for the simulations. The effect of pressure, RF frequency and trap dimensions has been investigated. The shape of stability diagrams at non-zero pressure is drastically different from the one observed in vacuum. Preliminary experimental results are shown, using a r = z = 3 mm-long CIT at 12 Torr for trapping peptide and protein ions.
Syntrophin mutation associated with long QT syndrome through activation of the nNOS–SCN5A macromolecular complex (2008)

Mutations in 11 genes that encode ion channels or their associated proteins cause inherited long QT syndrome (LQTS) and account for approximately 75-80% of cases (LQT1-11). Direct sequencing of SNTA1, the gene encoding alpha1-syntrophin, was performed in a cohort of LQTS patients that were negative for mutations in the 11 known LQTS-susceptibility genes. A missense mutation (A390V-SNTA1) was found in a patient with recurrent syncope and markedly prolonged QT interval (QTc, 530 ms). SNTA1 links neuronal nitric oxide synthase (nNOS) to the nNOS inhibitor plasma membrane Ca-ATPase subtype 4b (PMCA4b); SNTA1 also is known to associate with the cardiac sodium channel SCN5A. By using a GST-fusion protein of the C terminus of SCN5A, we showed that WT-SNTA1 interacted with SCN5A, nNOS, and PMCA4b. In contrast, A390V-SNTA1 selectively disrupted association of PMCA4b with this complex and increased direct nitrosylation of SCN5A. A390V-SNTA1 expressed with SCN5A, nNOS, and PMCA4b in heterologous cells increased peak and late sodium current compared with WT-SNTA1, and the increase was partially inhibited by NOS blockers. Expression of A390V-SNTA1 in cardiac myocytes also increased late sodium current. We conclude that the A390V mutation disrupted binding with PMCA4b, released inhibition of nNOS, caused S-nitrosylation of SCN5A, and was associated with increased late sodium current, which is the characteristic biophysical dysfunction for sodium-channel-mediated LQTS (LQT3). These results establish an SNTA1-based nNOS complex attached to SCN5A as a key regulator of sodium current and suggest that SNTA1 be considered a rare LQTS-susceptibility gene.
Offset locking of an SG-DBR to an InGaAsP/InP mode-locked laser (2012)

We demonstrate a Sampled Grating-Distributed Bragg Reflector (SG-DBR) laser offset locked at 6.5 GHz from a diode mode-locked laser comb using an integrated optical phase-locked loop (OPLL).
Functional imaging reveals rapid reorganization of cortical activity after parietal inactivation in monkeys (2012)

Impairments of spatial awareness and decision making occur frequently as a consequence of parietal lesions. Here we used event-related functional MRI (fMRI) in monkeys to investigate rapid reorganization of spatial networks during reversible pharmacological inactivation of the lateral intraparietal area (LIP), which plays a role in the selection of eye movement targets. We measured fMRI activity in control and inactivation sessions while monkeys performed memory saccades to either instructed or autonomously chosen spatial locations. Inactivation caused a reduction of contralesional choices. Inactivation effects on fMRI activity were anatomically and functionally specific and mainly consisted of: (i) activity reduction in the upper bank of the superior temporal sulcus (temporal parietal occipital area) for single contralesional targets, especially in the inactivated hemisphere; and (ii) activity increase accompanying contralesional choices between bilateral targets in several frontal and parieto-temporal areas in both hemispheres. There was no overactivation for ipsilesional targets or choices in the intact hemisphere. Task-specific effects of LIP inactivation on blood oxygen level-dependent activity in the temporal parietal occipital area underline the importance of the superior temporal sulcus for spatial processing. Furthermore, our results agree only partially with the influential interhemispheric competition model of spatial neglect and suggest an additional component of interhemispheric cooperation in the compensation of neglect deficits.
In-Situ TiC-Fe Deposition on Mild Steel Using a Laser Cladding Process (2011)

The growing interest in increasing the wear resistance and hardness of surfaces that are in contact with abrasives or corrosive materials has inspired the development of several processes for creating protective coatings. In-situ laser cladding is one of the most promising of these processes. It enables the formation of a uniform coating by melting powder to form the desired composition from a pure powder component.\nIn this research, pure Ti, graphite, and Fe are used for in-situ laser cladding on a steel substrate to form an Fe-TiC metal matrix composite (MMC). The effect of laser parameters on both the quality of the bonding and morphology of the in-situ-formed TiC iron-based composite clad are investigated. Results show that laser parameters play a crucial role in determining the clad quality and clad microstructure. Two combined parameters, effective energy and powder deposition density, are used to study the effect of laser parameters (i.e., laser power, scan speed and powder feed rate) on the clad properties. While results indicate that combined parameters help to determine the quality limit, laser process parameters need to be taken into account in order to study the clad microstructure.\nTo increase the clad hardness and TiC volume fraction, C:Ti atomic ratio should increase from 45:55 to 55:45, and Fe percentages in the powder composition should decrease from 70 wt% to the 10 wt%. By varying the powder composition, a change in TiC morphology, clad microstructure and clad hardness occurs. The dilution effect is also considered in the interpretation of results.\nIn order to estimate wear resistance, the ASTM G65-A procedure was selected to perform tests on various clad compositions. An increased wear resistance is seen when the volume fraction of TiC is increased.
Structure-sensitive search-match procedure for powder diffraction (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructure-sensitive search-match procedure for powder diffractionLudo K. FrevelCite this: Anal. Chem. 1982, 54, 4, 691–697Publication Date (Print):April 1, 1982Publication History Published online1 May 2002Published inissue 1 April 1982https://pubs.acs.org/doi/10.1021/ac00241a021https://doi.org/10.1021/ac00241a021research-articleACS PublicationsRequest reuse permissionsArticle Views39Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
High-density reRAM for storage class memory (2015)

This paper highlights selection process for ReRAM development, key challenges faced when implementing high-density ReRAM, and reports on 16Gb Cu-ReRAM designed at the 27nm node, with 200MB/s write and 1GB/s read throughputs.
alpha-methyldopa reduces locomotor activity in rats via its metabolite, alpha-methylnorepinephrine, acting on alpha 2-adrenoceptors. (1980)

The decrease in locomotor activity in rats caused by alpha-methyldopa (alpha-MD), 400 mg/kg p.o. was antagonized by treatment with yohimbine, a selective antagonist of alpha 2-adrenoceptors. Effective doses of yohimbine ranged from 0.25--2.0 mg/kg s.c., whereas yohimbine at 0.125 mg/kg did not significantly affect the decrease in locomotor activity caused by alpha-MD. Similar results were obtained in studies on the interaction between clonidine injected intracisternally and various doses of yohimbine given s.c., except that the higher doses of yohimbine completely blocked the depression of locomotor activity caused by clonidine, but not by alpha-MD. The depression of motor activity following alpha-MD was not offset by prazosin, a preferential alpha 1-antagonist. At the same doses that failed to alter the action of alpha-MD, prazosin was effective in antagonizing the increase in motor activity resulting from intracisternally injected methoxamine, a selective agonist, at alpha 1-receptors. Treatment with FLA-63, using a regimen that was shown to inhibit dopamine-beta-hydroxylase in brain, caused a diminution in the ability of alpha-MD to depress locomotor activity. These findings indicate that alpha-MD reduces locomotor activity in the rat at least in part via the formation of alpha-methylnorepinephrine which acts on alpha 2-adrenoceptors.
TMC-69, a New Antitumor Antibiotic with Cdc25A Inhibitory Activity, Produced by Chrysosporium sp. TC1068. (2001)

A new antibiotic designated TMC-69 has been isolated from the fermentation broth of a fungal strain Chrysosporium sp. TC 1068. TMC-69 exhibited moderate in vitro cytotoxic activity. TMC-69-6H, a derivative of TMC-69 prepared by hydrogenation, possessed more potent in vitro cytotoxicity than TMC-69, and exhibited in vivo antitumor activity against murine P388 leukemia and B16 melanoma. TMC-69-6H was found to specifically inhibit Cdc25A and B phosphatases.
The Properties of Zirconium (1949)

Critical review of the information on zirconium, with estimates of the uncertainty in the values.
The antigenicity in guinea pigs and monkeys of three mycobacterial polysaccharides purified by affinity chromatography with concanavalin A. (1975)

In laboratory sound insulation measurements on glazings a special putty is prescribed for sealing the perimeter to prevent sound leakages: Perennator TX 2001 S\nApplying this putty is very tiresome.\nA possible substitute for this putty has been suggested: Norseal 2520.\nTo compare the sealing quality of this foam to that of Perennator, a Round Robin test has been organised in which 23 laboratories in Europe participated. Two types of glazing, a common double glazing and a high performance one, have been used as test objects.\nA test programme has been developed. In it some measurements were aimed at a comparison of the Norseal foam and the Perennator putty.\nHowever, most measurements concerned the repeatability and reproducibility of the test method of ISO 140-2, determined from the test results, using the foam as sealant.\nThis report contains only the results carried out in the transmission rooms of the Acoustics Laboratory of Eindhoven University of Technology, Faculty of Architecture, Building and Planning. In this Round Robin it acted as the representative of TNO.\nThese results have only been compared with the average values of all Round Robin results.\nThe overall conclusion is:\n• Using Norseal foam instead of Perennator does not lead to large differences – less than 1 dB- in test results, for both test objects and for results of TU/e Acoustics Laboratory as well as the average RR-results;\n• Test results of TU/e Acoustics Laboratory are very similar to the averaged values of all RR test results for both test objects.
Varying patterns of expression of insulin-like growth factors I and II and their receptors in murine mammary adenocarcinomas of different metastasizing ability (1996)

We studied the expression of insulin-like growth factors I (IGF-I) and II (IGF-II) and their receptors (IGF-R) in 2 related murine mammary adenocarcinoma in vivo lines, M3 and MM3, with different metastasizing ability. We further investigated the effects of IGFs on the secretion of a key enzyme in the metastatic cascade, the urokinase-type plasminogen activator (uPA) in M3 and MM3 cells. M3 is a spontaneous mammary tumor originated in BALB/c mice, with a 40% incidence of lung metastases. MM3 variant, obtained by successive s.c. implants of M3 lung metastases into syngeneic mice, shows a 95% incidence of lung metastases. Similar levels of expression of IGF-I protein were found in M3 and MM3 tumors, whereas IGF-II expression was 4-fold higher im MM3. RNAse protection assays showed similar levels of IGF-I mRNA in M3 and MM3 tumors and revealed a 4-fold increase in IGF-II transcripts in MM3 tumors compared with M3. Authentic IGF-I and II messages were also found in primary cultures of M3 and MM3 cells. IGF-I mRNA levels were similar in both cultures and, as described for solid tumors a 5-fold increase in IGF-II message was detected in MM3 cells. The presence of type I and mannose-6-phosphate (Man-6P)/type II IGF-R was demonstrated in both M3 and MM3 tumors. A 2-fold increase of type I IGF-R was detected in MM3 tumors compared with M3. Man-6P/type II IGF-R levels were 2-fold lower in MM3 tumors than in M3. As observed in tumor membranes, type I IGF-R concentrations were higher and Man-6P/type II IGF-R lower in cultures of MM3 epithelial cells compared with MM3 cells. In addition, we found that IGF-I enhanced secreted uPA activity in both M3 and MM3 cells while IGF-II only stimulated uPA secretion in MM3 cells.
High performance CMOS in silicide to sapphire (CMOS/STS) (2003)

Summary form only given, as follows. HIgh-performance circuitry has been designed, simulated, fabricated, and tested in 100-nm thick double-solid-phase-epitaxy SOS. The source and drain regions outside the oxide sidewall spacers were silicided to the sapphire substrate, thereby providing self-aligned contacts to the transistors as well as an additional level of interconnects. The n/sup +/ and p/sup +/ regions under the oxide sidewalls serve as the actual source and drain regions. Ring oscillators with a 1.25- mu m gate length exhibit 120-ps gate delays, which compare well to simulation results of 125 ps. Simulations of electron-beam-written 0.5- mu m-gate-length ring oscillators predict gate delays of about 40 ps.
Molecular Dynamics Simulation of Amorphous SiO<sub>2</sub> Nanoparticles (2007)

Molecular dynamics simulation of amorphous SiO2 spherical nanoparticles has been carried out in a model with different sizes, 2, 4, and 6 nm, under non-periodic boundary conditions. We use the pair interatomic potentials which have weak Coulomb interaction and Morse type short-range interaction. Models have been obtained by cooling from the melt via molecular dynamics (MD) simulation. Structural properties of amorphous nanoparticles obtained at 350 K have been studied via partial radial distribution functions (PRDFs), mean interatomic distances, coordination numbers, and bond-angle distributions, which are compared with those observed in the bulk. Calculations of the radial density profile in nanoparticles show the tendency of oxygen to concentrate at the surface as observed previously in other amorphous clusters or thin films. Size effects on structure of nanosized models are significant. The calculations show that if the size is larger than 4 nm, amorphous SiO2 nanoparticles have a distorted tetrahedral network structure with the mean coordination number ZSi-O approximately 4.0 and ZO-Si approximately 2.0 like those observed in the bulk. Surface structure, surface energy, and glass transition temperature of SiO2 nanoparticles have been obtained and presented.
A broadband Doherty power amplifier without a quarter-wave impedance inverting network (2012)

A new Doherty power amplifier topology without a quarter-wave impedance inverting network is proposed. This topology enables the enhancement of amplifier bandwidth and achieves a more compact amplifier size. In order to remove an inverting network, the output matching network of the carrier amplifier is designed to realize high performance both at a low-RF level in the off-state of a peaking amplifier and at the RF saturation level. A 1.9-GHz Doherty amplifier without a quarter-wave impedance inverting network was designed and fabricated using GaN HEMTs. A series-connection-type amplifier using an output-combining balun was realized in a lumped-element circuit configuration. The amplifier achieved a power-added efficiency (PAE) of 51% at an output power of 29 dBm under an 11-dB input back-off from a 34-dBm saturated output power with a power-added efficiency of 59%. A maximum PAE higher than 48% was obtained over a frequency range of 1.67 to 1.97 GHz.