gebhart/patrepeval huggingface dataset:
Self-Powered Wireless Smart Sensor Node Enabled by an Ultrastable, Highly Efficient, and Superhydrophobic-Surface-Based Triboelectric Nanogenerator (2016)

Wireless sensor networks will be responsible for a majority of the fast growth in intelligent systems in the next decade. However, most of the wireless smart sensor nodes require an external power source such as a Li-ion battery, where the labor cost and environmental waste issues of replacing batteries have largely limited the practical applications. Instead of using a Li-ion battery, we report an ultrastable, highly efficient, and superhydrophobic-surface-based triboelectric nanogenerator (TENG) to scavenge wind energy for sustainably powering a wireless smart temperature sensor node. There is no decrease in the output voltage and current of the TENG after continuous working for about 14 h at a wind speed of 12 m/s. Through a power management circuit, the TENG can deliver a constant output voltage of 3.3 V and a pulsed output current of about 100 mA to achieve highly efficient energy storage in a capacitor. A wireless smart temperature sensor node can be sustainably powered by the TENG for sending the real-time temperature data to an iPhone under a working distance of 26 m, demonstrating the feasibility of the self-powered wireless smart sensor networks.
Why Do Pertussis Vaccines Fail? (2012)

* Abbreviations:
 DTaP — : pediatric diphtheria and tetanus toxoids and acellular pertussis vaccine
 DTP — : pediatric diphtheria and tetanus toxoids and whole-cell pertussis vaccine
 FHA — : filamentous hemagglutinin
 FIM — : fimbriae
 PCR — : polymerase chain reaction
 PRN — : pertactin
 PT — : pertussis toxin
 WHO — : World Health Organization

During the 2010 pertussis epidemic in California, there was considerable concern in the press and in public health communications about the possible contribution of vaccine failures to the problem.1,2 In this commentary, I examine why pertussis vaccines fail and Table 1 lists 8 possible reasons.

View this table:

TABLE 1 
Possible Reasons Why DTP, DTaP, and Adolescent- and Adult-Formulated Tetanus and Diphtheria Toxoids and Acellular Pertussis Vaccines Fail



The first reason, and perhaps the most important one, is that our estimates of vaccine efficacy have been inflated because of case definition.3–11 At the time of the pediatric diphtheria and tetanus toxoids and acellular pertussis (DTaP) vaccine efficacy trials in the early 1990s, it was hoped that a universal case definition could be developed so that the results of the various trials could be compared. To this end, the World Health Organization (WHO) case definition was developed.3 The primary case definition required laboratory confirmation and ≥21 days of paroxysmal cough. I was a member of the WHO committee and disagreed with the primary case definition because it was clear at that time that this definition would eliminate a substantial number of cases and therefore inflate reported efficacy values.4–11 Nevertheless, the Center for Biologics Evaluation and Research of the Food and Drug Administration accepted this definition, and package inserts of the US-licensed DTaP vaccines reflect this. For example, Infanrix (containing 25 μg pertussis toxin [PT], 25 μg filamentous hemagglutinin [FHA], and 8 μg pertactin [PRN]) and Daptacel (containing 10 μg PT, 5 μg FHA, 5 μg fimbriae [FIM]-2/3, and 3 μg … 

Address correspondence to James D. Cherry, MD, MSc, Department of Pediatrics, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave, MDCC 22-442, Los Angeles, CA 90095-1752. E-mail: jcherry{at}mednet.ucla.edu
Relative affinities of all Escherichia coli aminoacyl-tRNAs for elongation factor Tu-GTP. (1984)

The relative affinities of all Escherichia coli amino-acyl-tRNAs for E. coli elongation factor (EF) Tu-GTP have been measured by two independent applications of the competition form of the ribonuclease resistance assay. The set of aminoacyl-tRNAs includes at least one tRNA for each of the 20 amino acids as well as purified isoacceptor tRNA species for arginine, glycine, leucine, lysine, and tyrosine. In the first competition study, [3H]Phe-tRNA was used as the competing aminoacyl-tRNA against [14C]aminoacyl-tRNA in the set of all tRNAs; in the second study, [3H]Leu-tRNALeu4 was used as the competing aminoacyl-tRNA. The relative order of aminoacyl-tRNA affinities for EF-Tu-GTP was the same in each study. The results indicate that the affinity of EF-Tu-GTP at 4 degrees C, pH 7.4, is strongest for Gln-tRNA and weakest for Val-tRNA. Both Gly-tRNA and Pro-tRNA bind very strongly to EF-Tu-GTP relative to other aminoacyl-tRNAs. Various models of ternary complex interactions are discussed in light of the new data. Although the properties of the amino acid substituent are primarily responsible for the differences in relative affinities among the noninitiator aminoacyl-tRNAs, the results for the four isoacceptor species of Leu-tRNALeu indicate that the secondary structural features of the tRNA are also influential.
Characterization of the Inhibitory Effect of Growth Hormone on Primary Preadipocyte Differentiation (1998)

GH exerts adipogenic activity in several preadipocyte cell lines, whereas in primary rat preadipocytes, GH has an antiadipogenic activity. To better understand the molecular mechanism involved in adipocyte differentiation, the expression of adipocyte-specific genes was analyzed in differentiating preadipocytes in response to GH. We found that the expression of both adipocyte determination and differentiation factor 1 (ADD1) and peroxisome proliferator activated receptor gamma(PPARgamma) was induced in preadipocytes during differentiation. In the presence of GH, which markedly inhibited triglyceride accumulation, no reduction in the expression level of ADD1 was observed in response to GH, whereas there was a 50% reduction in the expression of PPARgamma. The DNA binding activity of the PPARgamma/retinoid X receptor-alpha(RXRalpha) to the ARE7 element from the aP2 gene was also reduced by approximately 50% in response to GH. GH inhibited the expression of late markers of adipocyte differentiation, fatty acid synthase, aP2, and hormone-sensitive lipase by 70-80%. The antiadipogenic effect of GH was not affected by the mitogen-activated protein (MAP) kinase/ extracellular-regulated protein (ERK) kinase inhibitor PD 98059, indicating that the mitogen-activated protein kinase pathway was not involved in GH inhibition of preadipocyte differentiation. The expression of preadipocyte factor-1/fetal antigen 1 was decreased during differentiation, and GH treatment prevented this down-regulation of Pref1/FA1. A possible role for Pref-1/FA1 in mediating the antiadipogenic effect of GH was indicated by the observation that FA1 inhibited differentiation as effectively as GH. These data suggest that GH exerts its inhibitory activity in adipocyte differentiation at a step after the induction of ADD1 but before the induction of genes required for terminal differentiation.
SNMP and SNMPv2: the infrastructure for network management (1998)

The Simple Network Management Protocol is the most widely used protocol for the management of IP-based networks and internets. The original version, now known as SNMPv1, is widely deployed. SNMPv2 adds functionality to the original version but does not address its security limitations; this relatively recent standard has not achieved much acceptance. An effort is currently underway to develop SNMPv3, which will retain the functional enhancements of SNMPv2 and add powerful privacy and authentication features. This article provides a survey of the three versions of SNMP, including a discussion of the way in which management information is represented and the protocol functionality.
Deterpenation of Citrus Essential Oil by Liquid−Liquid Extraction with 1-Alkyl-3-methylimidazolium Bis(trifluoromethylsulfonyl)amide Ionic Liquids (2011)

Three 1-alkyl-3-methylimidazolium bis(trifluoromethylsulfonyl)amide ionic liquids, namely, those with ethyl-, hexyl-, or decyl- as the alkyl substituent chain, were evaluated as potential solvents for the deterpenation of citrus essential oil by liquid−liquid extraction. The citrus essential oil was simulated as a mixture of the terpene limonene and the oxyterpene linalool. The liquid−liquid equilibrium data for the ternary systems formed by limonene, linalool, and each of the ionic liquids selected were experimentally determined at 298.15 K. The suitability of the ionic liquids as solvents for the proposed process was evaluated by means of solute distribution ratio and selectivity values. The influence of the alkyl side chain in the imidazolium cation of the ionic liquids on the liquid−liquid equilibrium data was analyzed. By comparison with data previously reported in the literature for analogous systems, the influence of the ionic liquid anion on the proposed separation was also analyzed. The experimental data were satisfactorily correlated by means of both the nonrandom two-liquid (NRTL) and the universal quasichemical activity coefficient (UNIQUAC) thermodynamic models.
Muscarinic Acetylcholine Receptor Subtypes as Potential Drug Targets for the Treatment of Schizophrenia, Drug Abuse, and Parkinson’s Disease (2011)

The neurotransmitter dopamine plays important roles in modulating cognitive, affective, and motor functions. Dysregulation of dopaminergic neurotransmission is thought to be involved in the pathophysiology of several psychiatric and neurological disorders, including schizophrenia, Parkinson's disease and drug abuse. Dopaminergic systems are regulated by cholinergic, especially muscarinic, input. Not surprisingly, increasing evidence implicates muscarinic acetylcholine receptor-mediated pathways as potential targets for the treatment of these disorders classically viewed as "dopamine based". There are five known muscarinic receptor subtypes (M(1) to M(5)). Due to their overlapping expression patterns and the lack of receptor subtype-specific ligands, the roles of the individual muscarinic receptors have long remained elusive. During the past decade, studies with knock-out mice lacking specific muscarinic receptor subtypes have greatly advanced our knowledge of the physiological roles of the M(1)-M(5) receptors. Recently, new ligands have been developed that can interact with allosteric sites on different muscarinic receptor subtypes, rather than the conventional (orthosteric) acetylcholine binding site. Such agents may lead to the development of novel classes of drugs useful for the treatment of psychosis, drug abuse and Parkinson's disease. The present review highlights recent studies carried out using muscarinic receptor knock-out mice and new subtype-selective allosteric ligands to assess the roles of M(1), M(4), and M(5) receptors in various central processes that are under strong dopaminergic control. The outcome of these studies opens new perspectives for the use of novel muscarinic drugs for several severe disorders of the CNS.
Schizofreni – hva viser strukturell MR? (2013)

The research literature shows that schizophrenia has neuroanatomical correlates that can be seen at group level by studying MR images. Structural MRI cannot currently be used to identify schizophrenia at the level of the individual.
Integrated Management of Fusarium Wilt of Chickpea with Sowing Date, Host Resistance, and Biological Control (2004)

ABSTRACT A 3-year experiment was conducted in field microplots infested with Fusarium oxysporum f. sp. ciceris race 5 at Córdoba, Spain, in order to assess efficacy of an integrated management strategy for Fusarium wilt of chickpea that combined the choice of sowing date, use of partially resistant chickpea genotypes, and seed and soil treatments with biocontrol agents Bacillus megaterium RGAF 51, B. subtilis GB03, nonpathogenic F. oxysporum Fo 90105, and Pseudomonas fluorescens RG 26. Advancing the sowing date from early spring to winter significantly delayed disease onset, reduced the final disease intensity (amount of disease in a microplot that combines disease incidence and severity, expressed as a percentage of the maximum possible amount of disease in that microplot), and increased chickpea seed yield. A significant linear relationship was found between disease development over time and weather variables at the experimental site, with epidemics developing earlier and faster as mean temperature increased and accumulated rainfall decreased. Under conditions highly conducive for Fusarium wilt development, the degree of disease control depended primarily on choice of sowing date, and to a lesser extent on level of resistance of chickpea genotypes to F. oxysporum f. sp. ciceris race 5, and the biocontrol treatments. The main effects of sowing date, partially resistant genotypes, and biocontrol agents were a reduction in the rate of epidemic development over time, a reduction of disease intensity, and an increase in chickpea seedling emergence, respectively. Chickpea seed yield was influenced by all three factors in the study. The increase in chickpea seed yield was the most consistent effect of the biocontrol agents. However, that effect was primarily influenced by sowing date, which also determined disease development. Effectiveness of biocontrol treatments in disease management was lowest in January sowings, which were least favorable for Fusarium wilt. Sowing in February, which was moderately favorable for wilt development, resulted in the greatest increase in seed yield by the biocontrol agents. In March sowings, which were most conducive for the disease, the biocontrol agents delayed disease onset and increased seedling emergence. B. subtilis GB03 and P. fluorescens RG 26, applied either alone or each in combination with nonpathogenic F. oxysporum Fo 90105, were the most effective treatments at suppressing Fusarium wilt, or delaying disease onset and increasing seed yield, respectively. The importance of integrating existing control practices, partially effective by themselves, with other control measures to achieve appropriate management of Fusarium wilt and increase of seed yield in chickpea in Mediterranean-type environments is demonstrated by the results of this study.
ChemInform Abstract: Substitution of Iron for Cobalt in Rare Earth Boride Permanent Magnets of the Type CO<sub>3 n+5</sub>Sm<sub>n+1</sub>Bm<sub>2n</sub>. (1983)

Abstract Der F e‐Einbau in die Co‐Plätze der Titeldauermagnete mit n: 1, 2, 3 wirkt sich auf zweierlei Weise günstig aus, nämlich in einer Erhöhung der Sättigungsmagnetisierung und Curie‐Temp.
Speech Recognition with Segmental Conditional Random Fields: Final Report from the 2010 JHU Summer Workshop (2010)

Novel techniques in speech recognition are often hampered by the long road that must be followed to turn them into fully functional systems capable of competing with the state-of-the-art. In the 2010 JHU summer workshop, we explored the use of Segmental Conditional Random Fields as an integrating technology to augment the best conventional systems with information from novel scientific approaches.
ChemInform Abstract: Rebaudioside F, a Diterpene Glycoside from Stevia rebaudiana (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Resolution of a Job-Shop Problem with a Single Transport Robot and Buffer Facilities (2006)

This paper addresses the scheduling problem in job-shop with transportation constraints and extra constraints including but not limited to input/output buffer with limited capacity in front of machines. The problem can be efficiently modelized to a disjunctive graph and the solution generation can be limited to generation of transportation sequences. An efficient memetic genetic algorithm is promoted to provide solutions satisfying all system constraints. This work provides numerical experiments including a comparative study with the exact resolution of the problem of (A. Caumond et al., 2006) and the heuristic approach of (P. Lacomme et al., 2005)
Mechanisms of particle removal during brush scrubber cleaning (2004)

The article focuses on the mechanisms of particle removal during brush scrubber cleaning for nano-sized slurry particles. The removal of Clariant SiO 2 slurry particles with average size of 34nm from nitride substrates is investigated. To measure such nano-sized particles on wafers, the haze signal is used. After a scrubber clean, the uniformity of the particle radial surface concentration on a wafer is checked. The processing time effect on the particle removal is analysed afterwards. Based on rolling and lifting removal mechanisms, some initial models are developed to describe the particle radial surface concentration after scrubbing. By doing so, the removal mechanisms of scrubbing under varied scrubbing conditions are determined. Finally, some experimental evidences on the particle removal mechanisms are shown in this study.
Low-power digit-serial multipliers (2002)

Digit-serial implementation styles are best suited for implementation of digital signal processing systems which require moderate sampling rates. Digit-serial multipliers obtained using traditional unfolding techniques cannot be pipelined beyond a certain level because of the presence of feedback loops. In this paper, an alternative approach for the design of digit-serial multipliers is presented based on a novel cell replacement transformation. This transformation permits bit-level pipelining of the digit-serial multipliers thereby achieving sample speeds close to corresponding bit-parallel multipliers with significantly lower area. This increased sample speed can be traded with reduction in power supply voltage resulting in significant reduction in power consumption. The results show that for smaller digit-sizes (/spl les/4), the type-II multiplier consumes the least power and for larger digit-sizes, the type-I multiplier consumes the least power. It is also found that the optimum digit-size for least power consumption in type-I and type-III multipliers is /spl sim//spl radic/2W, where W represents the word length. The proposed digit-serial multipliers consume on an average 1.75 times lower power than the traditional digit-serial architectures for the non-pipelined case, and about 15 times lower power for the bit-level pipelined case.
Arginine vasopressin as a neurotransmitter in brain. (1998)

Arginine vasopressin (AVP) which exerts diverse biological effects in mammals is no more restricted to the posterior pituitary. Neurons containing AVP are seen in many other areas and in CNS vasopressinergic neurons are identified from the neocortex to the spinal cord. With the characterization of three different types of vasopressin receptor subtypes V1a, V1b and V2 responsible for its actions, their cloning and identification in different areas--especially in the brain many more hitherto unknown functions of AVP in brain has come to light. Added to this is the recently available specific vasopressin receptor antagonists. At present AVP seems to be involved in memory retrieval, learning, circadian time keeping, modulating the actions of area postrema and many other functions in brain. In the suprachiasmatic nuclei (SCN)--the biological clock--an area of the brain where the role of VP is still not very clear, VP is found to participate not only in transmitting the circadian rhythms to the rest of the brain but also serves the function of synchronizing and amplifying the pacemaker output of SCN. AVP can act not only as a neurotransmitter but also can stimulate the production of chemicals/neurotransmitters and thereby act as a mediator. It may be concluded that there is a central vasopressinergic system which participates in a variety of physiological and behavioral functions of brain.
Image database construction tools for RICOHBASE (2002)

There has been a rapid evolution in image processing technologies while at the same time the facilities/capabilities required/expected of image database systems have also increased. However, the variety of image peripherals and the differences between their data formats make system integration and extension difficult. To overcome this problem, a set of image database construction tools called IMAZONE was developed. A description is presented of IMAZONE and its underlying database management system RICOHBASE.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Overexpression of manganese superoxide dismutase in DU145 human prostate carcinoma cells has multiple effects on cell phenotype (1998)

Our results suggest novel mechanisms by which MnSOD overexpression may modulate the malignant phenotype, with potential applications in developing new therapies for prostate cancer.
The disulfide bonded ring of iso-rANP, unlike that of rANP, has potent cardiovascular activity (1990)

Iso-atrial natriuretic peptide (iso-rANP), a 45 amino acid peptide with a disulfide bond between residues 23 and 39, is a newly discovered second atrial hormone with considerable homology with rat atrial natriuretic peptide (rANP). We have reported that iso-rANP(1-45) has effects similar to rANP in anesthetized rats in causing hypotension, a decrease in heart rate, and an increase in urine flow and electrolyte excretion. In the present experiments, we found that, unlike the ring peptide of rANP (rANP(105-121)), bolus injections of the ring peptide of iso-rANP (iso-rANP(23-39)) had considerable effects on the circulation but only small effects on the kidney, compared with iso-rANP(1-45). However, the effects of iso-rANP(23-39) in causing hypotension and decreasing heart rate were transient compared with those of iso-rANP(1-45). When we substituted a glycine for arginine into the ring portion of iso-rANP at position 36, so that there were only three amino acids different from the ring of rANP, biological activity of iso-rANP(23-39) was retained. In our bioassay system, all of the circulatory effects and most of the renal effects of rANP are mediated via vagal sensory afferents. We found that the effects of the ring peptide of iso-rANP on the circulation and the kidney were unchanged following vagotomy. The results indicate that iso-rANP(23-39) mediates at least some biological effects by membrane receptor mechanisms different from those of rANP and that the ring portion of iso-rANP probably contributes to nonvagally mediated responses of iso-rANP(1-45).
Endothelial cell responses to micropillar substrates of varying dimensions and stiffness (2012)

In the vascular niche, the extracellular matrix (ECM) provides a structural scaffold with a rich ligand landscape of essential matrix proteins that supports the organization and stabilization of endothelial cells (ECs) into functional blood vessels. Many of the physical interactions between ECs and macromolecular components of the ECM occur at both the micron and submicron scale. In addition, the elasticity of the ECM has been shown to be a critical factor in the progress of the angiogenic cascade. Here, we sought to determine the effect of substrate topography and elasticity (stiffness) on EC behavior. Utilizing a unique SiO(2) substrate with an array of micropillars, we first demonstrate that micropillars with heights >3 μm significantly decrease EC adhesion and spreading. Fibronectin (Fn) patterning of 1 μm high micropillars enabled EC adhesion onto the micropillars and promoted alignment in a single-cell chain manner. We then developed a robust method to generate a soft micropillar substrate array made of polydimethylsiloxane (PDMS), similar to the SiO(2) substrate. Finally, we examined the kinetics of EC adhesion and spreading on the soft PDMS substrates compared to the stiff SiO(2) substrates. Culturing cells on the PDMS substrates demonstrated an enhanced EC elongation and alignment when compared to stiff SiO(2) with similar topographical features. We conclude that the elongation and alignment of ECs is coregulated by substrate topography and stiffness and can be harnessed to guide vascular organization.