gebhart/patrepeval huggingface dataset:
Full length cDNA sequence encoding a nuclease-sensitive element DNA binding protein (1991)

Journal Article Full length cDNA sequence encoding a nuclease-sensitive element DNA binding protein Get access Rukmini Kolluri, Rukmini Kolluri Department of Human Genetics, Roswell Park Cancer InstituteElm and Canton Streets, Buffalo, NY 14263, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Alan J. Kinniburgh Alan J. Kinniburgh * Department of Human Genetics, Roswell Park Cancer InstituteElm and Canton Streets, Buffalo, NY 14263, USA * To whom correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 19, Issue 17, 11 September 1991, Page 4771, https://doi.org/10.1093/nar/19.17.4771 Published: 11 September 1991 Article history Accepted: 09 July 1991 Published: 11 September 1991
Hidden fluid mechanics: Learning velocity and pressure fields from flow visualizations (2020)

For centuries, flow visualization has been the art of making fluid motion visible in physical and biological systems. Although such flow patterns can be, in principle, described by the Navier-Stokes equations, extracting the velocity and pressure fields directly from the images is challenging. We addressed this problem by developing hidden fluid mechanics (HFM), a physics-informed deep-learning framework capable of encoding the Navier-Stokes equations into the neural networks while being agnostic to the geometry or the initial and boundary conditions. We demonstrate HFM for several physical and biomedical problems by extracting quantitative information for which direct measurements may not be possible. HFM is robust to low resolution and substantial noise in the observation data, which is important for potential applications.
Design of Gradient Oxide-Bypassed Superjunction Power MOSFET Devices (2007)

The superjunction MOSFET power devices, such as p-n column superjunction (named SJ or CoolMOS) devices and oxide-bypassed (OB) devices, are highly recognized for their higher blocking capability and lower on-state resistance. However, the performance of SJ devices is greatly handicapped due to difficulties in formation of perfect charge-balanced SJ p-n columns by the current process technology, especially for devices with small widths and voltage ratings below 180 V. OB devices can be an alternative in this voltage region, which utilize the well established oxide thickness control in fabrication instead of the difficult doping control as in SJ devices. However, OB drift region electric field distribution is not as optimal as that in SJ devices. Gradient oxide-bypassed (GOB) structure enhances the performance of OB devices so that it can achieve a performance comparable to that of an ideal p-n column SJ device in the medium voltage range, and at the same time, requires simple process technology. Complete descriptions on the GOB device and related design issues are presented in this paper. Fabrication issues are also discussed with possible sacrificial materials and etchants for making the vertical graded oxide sidewalls. Design cases for 80, 120, and 180 V GOB devices are also illustrated for better understanding in the device.
Monolithic image-rejection optoelectronic up-converters that employ the MMIC process (1993)

The authors present very small 30-GHz-band monolithic image-rejection optoelectronic up-converters that employ the HEMT MMIC process for the first time. MMIC HEMT optoelectronic mixers are characterized by their direct photodetection and nonlinear characteristics. It is shown that common-source configurations have higher response than common-drain configurations, and up-converter applications are preferable to down-converter applications based on the HEMT direct photodetection characteristics. These characteristics are used to realize 30-GHz-band monolithic image-rejection optoelectronic up-converters. An in-phase divider and a branch-line hybrid with two HEMT optoelectronic mixers are successfully integrated in an MMIC chip with an area of 1.5 mm*1.1 mm. Fundamental performance is demonstrated and excellent wideband performance, which comes from the well-balanced operation of monolithic integrated circuits, is confirmed. These monolithic optoelectronic mixers can be used to realize compact and cost-effective one-chip optical receivers, for fiber optic links which support millimeter waves.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Un abordaje interdisciplinar en un diseño curricular disciplinar de carreras biológicas (2005)

A partir del diagnóstico elaborado por la comisión permanente de seguimiento y evaluación curricular (Facultad de Humanidades y Ciencias – Universidad Nacional del Litoral) durante el período 2000 – 2002, con relación a la organización académica disciplinar, las prácticas pedagógicas y la evaluación de los aprendizajes en las carreras: Profesorado en Biología y Licenciatura en biodiversidad, se detectan dificultades que obstaculizan a los alumnos alcanzar un aprendizaje significativo. Para superar las mismas proponemos establecer espacios curriculares, formados por asignaturas integradores, que permita a los alumnos, a través de diferentes estrategias didácticas, acceder al conocimiento según un enfoque interdisciplinar que considere la complejidad de la realidad estudiada.
Phase 2 trial of linifanib (ABT‐869) in patients with unresectable or metastatic hepatocellular carcinoma (2012)

Single-agent linifanib was found to be clinically active in patients with advanced hepatocellular carcinoma, with an acceptable safety profile.
Surgical treatment of scoliosis: a review of techniques currently applied (2008)

In this review, basic knowledge and recent innovation of surgical treatment for scoliosis will be described. Surgical treatment for scoliosis is indicated, in general, for the curve exceeding 45 or 50 degrees by the Cobb's method on the ground that:1) Curves larger than 50 degrees progress even after skeletal maturity.2) Curves of greater magnitude cause loss of pulmonary function, and much larger curves cause respiratory failure.3) Larger the curve progress, more difficult to treat with surgery.Posterior fusion with instrumentation has been a standard of the surgical treatment for scoliosis. In modern instrumentation systems, more anchors are used to connect the rod and the spine, resulting in better correction and less frequent implant failures. Segmental pedicle screw constructs or hybrid constructs using pedicle screws, hooks, and wires are the trend of today.Anterior instrumentation surgery had been a choice of treatment for the thoracolumbar and lumbar scoliosis because better correction can be obtained with shorter fusion levels. Recently, superiority of anterior surgery for the thoracolumbar and lumbar scoliosis has been lost. Initial enthusiasm for anterior instrumentation for the thoracic curve using video assisted thoracoscopic surgery technique has faded out.Various attempts are being made with use of fusionless surgery. To control growth, epiphysiodesis on the convex side of the deformity with or without instrumentation is a technique to provide gradual progressive correction and to arrest the deterioration of the curves. To avoid fusion for skeletally immature children with spinal cord injury or myelodysplasia, vertebral wedge ostetomies are performed for the treatment of progressive paralytic scoliosis. For right thoracic curve with idiopathic scoliosis, multiple vertebral wedge osteotomies without fusion are performed. To provide correction and maintain it during the growing years while allowing spinal growth for early onset scoliosis, technique of instrumentation without fusion or with limited fusion using dual rod instrumentation has been developed. To increase the volume of the thorax in thoracic insufficiency syndrome associated with fused ribs and congenital scoliosis, vertical expandable prosthetic titanium ribs has been developed.
Detection and location of internal defects in pieces by using perpendicular ultrasonic apertures (2010)

Ultrasonic inspection with a low number of transducers located in perpendicular planes, and working in near-field conditions, constitutes a recent evaluation tool with efficient behaviour for defect detection, because this option involves a low technological cost with a good spatial resolution. Each bi-dimensional elemental area of the tested piece is insonified by different transducers, and a high resolution two-dimensional representation can be obtained by using some digital signal processing techniques specifically developed for making echo-trace combinations. Two methods for acquisition of multiple A-scan lines, and three digital signal processing combination algorithms, together with some results related to the detections of multiple defects, are presented in the paper.
Providing psychological support to cancer patients. (1999)

Nurses may lack the confidence to deal with the psychological problems of patients with cancer. A nurse specialist in psychological support can help staff improve patient assessment. The specialist nurse can also undertake skilled psychological interventions.
Genetically Engineered Animals in Drug Discovery and Development: A Maturing Resource for Toxicologic Research (2004)

Genetically engineered mice that either over-express a foreign gene (transgenic) or in which the activity of a specific gene has been removed ("knock-out") or replaced ("knock-in") will be used increasingly to investigate molecular mechanisms of disease, to evaluate innovative therapeutic targets, and to screen novel agents for efficacy and/or toxicity. Recent innovations of relevance to toxicologic researchers include the construction of genetically engineered mice with (1) multiple engineered genes, (2) mutations that can be induced at specific sites and times throughout life, and (3) the substitution of human genes for their mouse counterparts ("humanized" mice) to allow in vivo investigation of xenobiotic toxicity. Contemporary applications of genetically engineered mice in toxicology include basic mechanistic research exploiting newly engineered mouse lines as well as applied screening for genotoxicity and carcinogenicity using commercially available animals. Many caveats must be considered when interpreting genetically engineered mice-derived toxicity data, the chief of which will be the extent to which the model's phenotype has been fully characterized, the type and incidence of background lesions for the given mouse strain and engineered gene, and the possibility of misinterpreting the presence or absence of a phenotype due to compensatory physiologic processes that mask the outcome produced by the engineering event. Toxicity data acquired using genetically engineered mice currently supplements and in time likely will supplant those gathered using the present "gold standard" bioassays, as genetically engineered mice typically develop more lesions after a shorter latency period than do age- and strain-matched, wild-type mice.
Experiments and modelling of electrospinning process (2005)

Very thin liquid jets can be obtained using electric field, whereas an electrically-driven bending instability occurs that enormously increases the jet path and effectively leads to its thinning by very large ratios, enabling the production of nanometre size fibres. This mechanism, although it was discovered almost one century ago, is not yet fully understood. In the following study, experimental data are collected, with the dual goal of characterizing the electro-spinning of different liquids and evaluating the pertinence of a theoretical model.
Wave‐CAIPI for highly accelerated 3D imaging (2014)

Wave-CAIPI allows highly accelerated 3D acquisitions with low artifact and negligible g-factor penalties, and may facilitate clinical application of high-resolution volumetric imaging.
Attention-Deficit/Hyperactivity Disorder (ADHD) and Binge Eating (2008)

Attention-deficit/hyperactivity disorder (ADHD) is characterized by a persistent and pervasive pattern of inattention and/or hyperactivity-impulsivity. Emerging data suggest higher than expected rates of binge eating occur in subjects with ADHD. Several hypotheses may explain this newly described comorbidity: 1) inattention and/or impulsivity foster binge eating, 2) ADHD and binge eating share common neurobiological bases, 3) binge eating contributes to ADHD, or 4) psychopathological factors common to both binge eating and ADHD mediate the association. In patients with ADHD and binge eating, both conditions might benefit from common therapeutic strategies. Further research is needed to gain insight into the association between ADHD and binge eating in order to facilitate more appropriate clinical management and, ultimately, a better quality of life for patients with both conditions.
Current aspects of stationary phase immobilization in open tubular column chromatography (1990)

Abstract In situ stationary phase immobilization in principle can be attempted in two different ways: using thermal methods or radical‐initiated reactions. Thermal immobilization, in general, is applied for the preparation of columns to be used at ultra‐high temperatures, and radical‐initiated immobilization can be applied in most other cases. For polar, narrow‐bore, and thick‐film columns, low immobilization temperatures are preferred. The reactions involved in the different immobilization methods are described in this review, and the advantages and disadvantages of current immobilization methods are discussed.
DocVQA: A Dataset for VQA on Document Images (2020)

We present a new dataset for Visual Question Answering (VQA) on document images called DocVQA. The dataset consists of 50,000 questions defined on 12,000+ document images. Detailed analysis of the dataset in comparison with similar datasets for VQA and reading comprehension is presented. We report several baseline results by adopting existing VQA and reading comprehension models. Although the existing models perform reasonably well on certain types of questions, there is large performance gap compared to human performance (94.36% accuracy). The models need to improve specifically on questions where understanding structure of the document is crucial. The dataset, code and leaderboard are available at docvqa.org
Ungewöhnliche ophthalmologische Erkrankungen beim Pferd: eine Herausforderung für Diagnostik und Therapie (2007)

Zusammenfassung Ziel: Darstellung verschiedener Erkrankungen des Auges, seiner Adnexe und seiner Umgebung mit ungewöhnlichem klinischem Verlauf und besonderen Anforderungen hinsichtlich Diagnostik und Behandlung. Material und Methoden: Präsentation von sechs Fallbeispielen. Ergebnisse: Eine jahrelang nicht erkannte Atresie des distales Abschnitts der tränenableitenden Wege ist vergleichsweise einfach operativ zu beheben. Auch schwerste Verletzungen des Gesichtsschädels lassen sich bei unversehrtem Bulbus und sorgfältiger, dem Heilungsverlauf angepasster Operationstechnik funktionell und kosmetisch gut behandeln. Auf der anderen Seite können äußerlich wenig spektakuläre stumpfe Traumen zu einer irreversiblen Schädigung des Sehnerven und zur Erblindung führen. Eine vollständige Erblindung kann auch ohne erkennbare Ursache als Folge einer seltenen Retinaatrophie eintreten. Bei den tumorösen Erkrankungen des Auges handelt es sich überwiegend um Plattenepithelkarzinome. Andere Tumoren lassen sich meist erst nach der Exstirpation des Bulbus oder nach der Euthanasie des Pferdes mithilfe histopathologischer und immunhistologischer Untersuchungen klassifizieren. Schlussfolgerung und klinische Relevanz: Das ideale Ergebnis der tierärztlichen Interventionen, ein normaler Visus, ist nicht in allen Fällen zu erreichen. In der Therapiekaskade sollte zunächst dieses Ziel angestrebt werden. Wenn dies nicht möglich ist, gilt es den Bulbus zu erhalten. Lässt sich auch das nicht mehr verantworten, muss eine Entfernung der erkrankten und zumeist schmerzhaften Organe erfolgen. Als Ultima Ratio ist letztlich eine Euthanasie des Patienten zu empfehlen, wenn das Tier trotz Behandlung nicht beschwerdefrei weiterleben kann.
THE CASE FOR SALTIGO (2006)

RETURN TO ISSUEPREVNewsNEXTTHE CASE FOR SALTIGOLanxess is betting that a revamped custom chemical business will finally turn a profitCite this: Chem. Eng. News 2006, 84, 11, 28Publication Date (Print):March 13, 2006Publication History Published online14 November 2010Published inissue 13 March 2006https://doi.org/10.1021/cen-v084n011.p028Copyright © 2006 American Chemical SocietyArticle Views7Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (769 KB) SUBJECTS:Manufacturing,Pharmaceuticals Get e-Alerts
The Story of the Institute. A Survey of Seven Years (1934)

The idea of founding the Institute crystallized at a meeting of missionaries, and others, which was held at High Leigh in September 1924. Dissatisfaction with the prevailing order of things occupied the minds of all who were faced with the burning problems in Africa at that time. They were not content to allow a negative policy of drift to continue. They realized that they were confronted with one of the major problems of our age. They saw the need for an application of scientific method to a solution of the questions arising generally from the contact of Western civilization with African culture and particularly from the attempt to educate Africans on modern lines. The rapid opening of Africa to all the influences of Europeanism, they were convinced, called for an advance in the education of the peoples of Africa through the medium of their own forms of thought. The linguistic question was seen to lie at the root of the problem. The more systematic study of African languages, of their relative importance and uses, of their orthography, was deemed to be urgently necessary if the progress of education was not to be retarded, or rendered impossible, through the prevailing confusion and lack of co-operation between governments, missionary societies, and scientific experts. Such were the ideas in the minds of those who took part in that meeting nine years ago and embodied in a memorandum which they drew up. These problems had already been raised in New York after the return of Dr. Jesse Jones and Dr. Aggrey from West Africa before the departure of the Phelps Stokes Education Commission to East Africa. It seemed to us at High Leigh that the time was ripe for the setting up of an organization to carry out these ideas. We thought then modestly of ‘A Bureau of African Languages and Literature’. Probably not one of us had a prevision of whereunto the thing would grow.
Safety, Tolerability, and Lack of Antibody Responses After Administration of a <i>Pf</i> CSP DNA Malaria Vaccine via Needle or Needle-Free Jet Injection, and Comparison of Intramuscular and Combination Intramuscular/Intradermal Routes (2002)

Introduction of a new vaccine requires choosing a delivery system that provides safe administration and the desired level of immunogenicity. The safety, tolerability, and immunogenicity of three monthly 2.5-mg doses of a PfCSP DNA vaccine were evaluated in healthy volunteers as administered intramuscularly (IM) by needle, IM by jet injection (Biojector or IM/intradermally (ID) by jet injection. Vaccine administration was well-tolerated. Adverse events were primarily mild and limited to the site of injection (98%). Jet injections (either IM or ID) were associated with approximately twice as many adverse events per immunization as needle IM, but nevertheless were strongly and consistently preferred in opinion polls taken during the study. No volunteers had clinically significant biochemical or hematologic changes or detectable anti-dsDNA antibodies. In conclusion, the injection of Plasmodium falciparum circumsporozoite (PfCSP) DNA vaccine appeared to be safe and well-tolerated when administered by any of the three modes of delivery. However, despite improved antibody responses following both jet injection and ID delivery in animal models, no antibodies could be detected in volunteers by immunofluorescence antibody test (IFAT) or enzyme-linked immunosorbent assay (ELISA) after DNA vaccination.
Comparison of non-thermal plasma techniques for abatement of volatile organic compounds and nitrogen oxides (1996)

Non-thermal plasma processing is an emerging technology for the abatement of dilute concentrations of volatile organic compounds (VOCs), nitrogen oxides (NO{sub x}) and other hazardous air pollutants (HAPs) in atmospheric-pressure gas streams. Either electrical discharge or electron beam methods can produce these plasmas. Recent laboratory-scale experiments show that the electron beam method is remarkably more energy efficient than competing non-thermal plasma techniques based on pulsed corona and other types of electrical discharge plasma. Preliminary cost analysis based on these data also show that the electron beam method may be cost-competitive to thermal and catalytic methods that employ heat recovery or hybrid techniques.
202. Stilbenecarboxylic acids (1948)

F. Bell and D. H. Waring, J. Chem. Soc., 1948, 1024 DOI: 10.1039/JR9480001024
A microcellular communications propagation model based on the uniform theory of diffraction and multiple image theory (1996)

Presents a comprehensive uniform theory of diffraction (UTD) propagation model for a city street grid, using the multiple image concept and the generalized Fermat's principle to describe the multiple reflections and diffractions. The model is a quasi 3D one in the sense that the building walls are assumed to be much higher than the transmitter height so that the diffractions from the rooftops can be neglected. The model includes all possible specular wall and ground reflections and corner diffractions in the main street, side streets, and parallel streets of a microcell. This enables the signal propagation through all the possible paths to be tracked to the receiver at various line-of-sight (LOS) or out-of-sight (OOS) positions. Previous papers on such propagation models have included only a limited number of specular reflections and diffractions or they are restricted to a rectilinear grid where all the building walls on each side of the street are coplanar. Our model includes contributions to the received signal from all possible propagation paths, including ground and wall reflections from diffracted and specularly reflected signals both in the LOS and OOS regions. Within the scope of the UTD model, the accuracy of our model is limited mainly by the assumptions of characterizing the building walls as "smoothed-out" flat surfaces with average relative permittivity /spl epsiv//sub r/ and conductivity /spl sigma/. Our theoretical results of the signal path loss along the streets are compared with measurements which have been reported for city streets in Tokyo and New York City.