gebhart/patrepeval huggingface dataset:
ChemInform Abstract: Synthesis of Heterocyclic Compounds Isosterically Related to Pyrazolo‐(4,3‐c)quinolines as Benzodiazepine Receptor Ligands. (1989)

Abstract Acid‐catalyzed cyclization of the hydrazinonicotinates (IV), prepared from ethyl 4‐chloronicotinate N‐oxide (I), yields the dihydropyrazolopyridinones (V).
METABOLISM OF METHYLGLYOXAL IN MICROORGANISMS (1984)

INTRODUCTION 49 A METHYl.GLYOXAL BYPASS OF THE EMBDEN·MEYERHOF PATHWAy...... 51 CYTOTOXIC NATURE OF METHYLGLYOXAL ........ 54 ENZYMA TJ[C FORMATION OF METHYLGLYOXAL 54 Studies on Methylglyoxal Synthase 54 Glyceraldehyde 3.Phosphate and Glyceraldehyde as Possible Precursors of Methylglyoxal 57 Acetol Dehydrogenase 57 Methylglyoxal from Aminoacetone 58 REACTIONS FOR THE UTILIZATION OF METHYLGLYOXAL 58 The Glyoxalase System 58 Methylg,yoxal Dehydrogen ase 60 Formaldehyde Dehydrogenase 60
Fabrication of patterned thermoplastic microphases between composite plies by inkjet printing (2014)

We report on the pioneering application of inkjet printing in depositing patterned thermoplastic microphases between composite plies and the beneficial effect of the printed thermoplastic on the interlaminar fracture toughness of carbon fibre-reinforced polymer laminates. Double-cantilever beam test and short-beam shear test were employed to investigate the mechanical performances of the engineered composites. The results from this work revealed that by printing thermoplastic poly(ethylene glycol) and poly(methyl methacrylate) between the carbon fibre-reinforced polymer plies, mode I interlaminar fracture toughness (G Ic ) is noticeably enhanced, whilst the shear strength has also been preserved. Scanning electron microscopy was used to investigate the fracture surfaces generated during the double-cantilever beam test. The microscopic addition of the thermoplastic polymers (approximately 0.015 wt%) did not increase the weight of the composites significantly, which compares favourably to other conventional toughening methods.
Effects of the parameters on the performance of a multi-carrier CDMA system in fading channel (2002)

In this paper, we consider a multicarrier-code division multiple access (MC-CDMA) system that combines the direct sequence spread spectrum (DS/SS) technique with MC modulation. The receiver provides a correlator for each carrier, and the outputs of the correlators are combined with an equal-gain combiner. We show the effects of the parameters that include the consideration of several selective fading channels, the number of subcarriers, the chip rate and the signal-to-noise ratio on the performance of the MC-CDMA system. We also compare the system performance with that of a single-carrier RAKE system. It is shown that the MC system is able to outperform the RAKE receiver when the system parameters are selected properly.
Improving coverage and load conditions through joint adaptation of antenna tilts and cell selection rules in mobile networks (2012)

One major topic of research into SON technology is the coordination of SON use cases. Network operators expect a coordinated handling of the parameter and configuration changes submitted to the operating network by closed-loop SON use case implementations. Beside a published conceptual framework, SON coordination has already been treated in the literature, especially regarding the mobility load balancing (MLB) and mobility robustness optimization (MRO) use cases. In this paper, we utilize the capacity and coverage optimization (CCO) and MLB use cases. Rather than performing any heading or tailing coordination of separate CCO and MLB algorithms, in our work we concentrate on the optimization considering both use cases in a joint algorithm. Our approach introduces cell-individual loads and the joint treatment of cell selection policies and antenna tilt settings into well-known and previously reported optimization concepts. Using system simulations of a sample LTE real deployment scenario, we verify that our joint optimization of antenna tilts and cell selection rules including the notion of cell-individual loads outperforms the optimization of tilts-only (with and without the notion of cell-individual loads within the algorithm) and of the cell selection rules-only in terms of spectral and energy efficiency.
Sensor integration options for low cost position and attitude determination (2002)

High performance marine inertial systems, such as those needed for sensor or weapon stabilization and control, tend to be large, heavy and expensive. Alternatives are therefore being considered, especially for smaller ships. The paper examines various options for Kalman filter integration of a lower performance inertial system with different GPS measurements, including GPS attitude.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Change Detection between Multimodal Remote Sensing Data Using Siamese\n CNN (2018)

Detecting topographic changes in the urban environment has always been an\nimportant task for urban planning and monitoring. In practice, remote sensing\ndata are often available in different modalities and at different time epochs.\nChange detection between multimodal data can be very challenging since the data\nshow different characteristics. Given 3D laser scanning point clouds and 2D\nimagery from different epochs, this paper presents a framework to detect\nbuilding and tree changes. First, the 2D and 3D data are transformed to image\npatches, respectively. A Siamese CNN is then employed to detect candidate\nchanges between the two epochs. Finally, the candidate patch-based changes are\ngrouped and verified as individual object changes. Experiments on the urban\ndata show that 86.4\\% of patch pairs can be correctly classified by the model.\n
Advances in Drug Therapy for Inflammatory Bowel Disease (1990)

Drug therapy for inflammatory bowel disease, limited for many years to sulfasalazine and some corticosteroids, has been extended to include the aminosalicylates, rapidly metabolized topical steroids, immunosuppressive agents, and metronidazole. Potentially useful newer drugs await further study.
Alumina-catalyzed reactions of hydroxyarenes and hydroaromatic ketones. II. Reactions of 1-oxo-2,2-dimethyl-1,2-dihydronaphthalene, 1-oxo-4,4-dimethyl-1,4-dihydronaphthalene, and 1-methoxynaphthalene with methanol (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAlumina-catalyzed reactions of hydroxyarenes and hydroaromatic ketones. II. Reactions of 1-oxo-2,2-dimethyl-1,2-dihydronaphthalene, 1-oxo-4,4-dimethyl-1,4-dihydronaphthalene, and 1-methoxynaphthalene with methanolJoseph Shabtai, LeRoy H. Klemm, and Dennis Riley TaylorCite this: J. Org. Chem. 1968, 33, 4, 1489–1493Publication Date (Print):April 1, 1968Publication History Published online1 May 2002Published inissue 1 April 1968https://pubs.acs.org/doi/10.1021/jo01268a037https://doi.org/10.1021/jo01268a037research-articleACS PublicationsRequest reuse permissionsArticle Views57Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
CAD for HERMES antennas (2003)

During the launch, landing and orbit phases of the proposed HERMES spacecraft, telecommand data (10 kb/s) and telemetry data (25 kb/s) are transmitted between HERMES and the ground by a relay satellite. An analysis of operational requirements resulted in the selection of four switched antennas, integrated within the plane structure, each of which may comprise several antennas. The two software packages used assess the performance of these antennas are briefly reviewed. The first package is for implementing the boundary element method (BEM). The program is executed on a DEC VAX 8600 and the linear system, whose matrix is complex, symmetrical and complete, is solved on an array processor, FPS 164/MAX. The electromagnetic characteristics (radiation patterns, surface currents, etc.) of the antenna are displayed graphically. The other package, SARGASSES, is an interactive simulator for antennas on structures such as aircraft or spacecraft.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Utilizing the SNA Alert in the management of multivendor networks (1988)

Managing multivendor networks is one of the largest challenges facing vendors and customers in data processing and telecommunications. This paper focuses on one aspect of managing multivendor network environments: problem notification, isolation, and resolution, via Systems Network Architectures Alert. It describes an extension to the SNA Alert function, termed the generic Alert, that makes it possible for various vendors products, as well as customer-written applications, to send Alerts of the same type to a single Alert receiver. It also describes IBM's implementation of the Alert receiver for the System/370, the NetView™ program product. Among the facilities that the generic Alert architecture provides to an Alert sender are the following: (1) code points that index short descriptions of Alert conditions, probable causes of these conditions, and recommended operator actions; and (2) vehicles to carry product-unique text. This text can be used for further characterizing an Alert condition or specifying a particular operator action.
A new multichannel split Levinson algorithm for block Hermitian-Toeplitz matrices (1989)

A review is presented of the vector Levinson and multichannel split algorithms for block Hermitian-Toeplitz matrices. The author then introduces a new multichannel split algorithm for block Hermitian-Toeplitz matrices. The algorithm does not save any multiplications, but it does require only one matrix inversion per recursion, whereas the vector Levinson and previous multichannel split algorithm both require two matrix inversions per recursion.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A Nonessential African Swine Fever Virus Gene <i>UK</i> Is a Significant Virulence Determinant in Domestic Swine (1998)

Sequence analysis of the right variable genomic region of the pathogenic African swine fever virus (ASFV) isolate E70 revealed a novel gene, UK, that is immediately upstream from the previously described ASFV virulence-associated gene NL-S (L. Zsak, Z. Lu, G. F. Kutish, J. G. Neilan, and D. L. Rock, J. Virol. 70:8865-8871, 1996). UK, transcriptionally oriented toward the right end of the genome, predicts a protein of 96 amino acids with a molecular mass of 10.7 kDa. Searches of genetic databases did not find significant similarity between UK and other known genes. Sequence analysis of the UK genes from several pathogenic ASFVs from Europe, the Caribbean, and Africa demonstrated that this gene was highly conserved among diverse pathogenic isolates, including those from both tick and pig sources. Polyclonal antibodies raised against the UK protein specifically precipitated a 15-kDa protein from ASFV-infected macrophage cell cultures as early as 2 h postinfection. A recombinant UK gene deletion mutant, deltaUK, and its revertant, UK-R, were constructed from the E70 isolate to study gene function. Although deletion of UK did not affect the growth characteristics of the virus in macrophage cell cultures, deltaUK exhibited reduced virulence in infected pigs. While mortality among parental E70- or UK-R-infected animals was 100%, all deltaUK-infected pigs survived infection. Fever responses were comparable in E70-, UK-R-, and deltaUK-infected groups; however, deltaUK-infected animals exhibited significant, 100- to 1,000-fold, reductions in viremia titers. These data indicate that the highly conserved UK gene of ASFV, while being nonessential for growth in macrophages in vitro, is an important viral virulence determinant for domestic pigs.
Relative contribution of leukotriene B4 to the neutrophil chemotactic activity produced by the resident human alveolar macrophage. (1987)

Human alveolar macrophages release chemotactic activity for neutrophils, providing a role for alveolar macrophages in regulating inflammation in the lung. As alveolar macrophages produce large amounts of leukotriene B4 (LTB4), a chemotactically active lipoxygenase product of arachidonic acid, we investigated the contribution of LTB4 to the total neutrophil chemotactic activity produced by these cells. Normal human alveolar macrophages were recovered by bronchoalveolar lavage from healthy volunteers and incubated either with the calcium ionophore A23187 for 1 h, or with opsonized zymosan particles or latex beads for 3 h. Nordihydroguaretic acid (NDGA), a relatively specific lipoxygenase inhibitor, blocked the release of neutrophil chemotactic activity after all three stimuli in a dose-dependent manner. This correlated with blockade of LTB4 production as measured by high performance liquid chromatography using freshly isolated alveolar macrophages, as well as blockade of [3H]LTB4 production by macrophages prelabeled with [3H]arachidonate. Molecular sieve chromatography using Sephadex G-50 confirmed that essentially all of the chemotactic activity in the stimulated macrophage supernatants co-eluted with authentic [3H]LTB4, and that NDGA completely blocked the chemotactic activity in the eluting fractions. Readdition of authentic LTB4 (1 X 10(-7) M) to the NDGA-blocked macrophage supernatants restored the chemotactic activity in the supernatants. The macrophage supernatants did not contain platelet-activating factor-like activity, as measured by the stimulation of [3H]serotonin release from rabbit platelets, and by high performance liquid chromatography. NDGA did not change the protein-secretion profiles of fresh alveolar macrophages, or of macrophages prelabeled with [35S]methionine. The complement (C) components C5adesarg were not detected in any of the supernatants by radioimmunoassay. Concentration of the supernatants by positive pressure filtration (5,000-D membrane) did not augment chemotactic activity in the stimulated supernatants or uncover chemotactic activity in the NDGA-blocked supernatants. As with the 3-h studies, when alveolar macrophages were incubated overnight with opsonized zymosan, all of the increase in chemotactic activity could also be blocked by NDGA. These data indicate that LTB4 is the predominant neutrophil chemotactic factor secreted by the normal resident human alveolar macrophage in response to two major types of stimuli, calcium fluxes across the cell membrane and the phagocytosis of opsonized particulates.
The Effects of Topical Antiglaucoma Drugs as Monotherapy on the Ocular Surface: A Prospective Study (2014)

Purpose. The aim was to compare the effects of antiglaucoma eye drops on the tear functions and ocular surface. Method. Eighty-five eyes of 43 patients with glaucoma were included into this randomized prospective study. Timolol without preservative (1), timolol with benzododecinium bromide (2), latanoprost (3), bimatoprost (4), travoprost with benzalkonium chloride (5), and brimonidine with purite (6) were given to 6 groups. Schirmer I, tear film breakup time (TBUT), staining scores, and impression cytology samples were evaluated before and during 12-month-follow-up period. Results. At the end of 12 months, there was no detected change in Schirmer I and TBUT tests indicating dry eye. Corneal staining scores were higher in groups 1 and 2, while conjunctival staining scores were higher in group 6. Goblet cell count decreased in groups 1 and 5 in superior and inferior, group 2 in superior, and groups 3 and 6 in inferior conjunctiva. Squamous metaplasia grades showed a significant increase in groups 1 and 2 at 3rd, 6th, and 12th month controls (P < 0.05). Conclusion. We observed nonserious impact on tear functions and ocular surface with antiglaucoma monotherapy. Beta blockers induced more damage on the ocular surface suggesting the role of the dosing and active substances beside preservatives.
Phosphorylation of PPARγ via active ERK1/2 leads to its physical association with p65 and inhibition of NF‐κβ (2003)

Peroxisome proliferator-activated receptors (PPAR) are novel nuclear receptors and PPARgamma ligands have been shown to produce pro-apoptotic effects in many cancer cell types, including colon cancer. PPARgamma ligands exert their effect through PPARgamma-dependent (genomic) and PPARgamma-independent (non-genomic) mechanisms. Recent evidence suggests that PPARgamma ligands exert their pro-apoptotic effects in part by directly antagonizing the NF-kappabeta pathway as well as through activation of the MAP kinase pathway. In this report, we have demonstrated that ciglitazone, a member of the thiazoldinedione class of PPARgamma ligands induces HT-29 colon cancer cells to undergo apoptosis and prior to apoptosis, ciglitazone exposure results in a transient phosphorylation of PPARgamma. This phosphorylation of PPARgamma was mediated through the ciglitazone-induced activation of Erk1/2. PPARgamma phosphorylation affected the genomic pathway by being inhibitory to PPARgamma-DNA binding and PPRE transcriptional activity, as well as the non-genomic pathway by increasing the physical interaction of PPARgamma with p65, leading to the inhibition of NF-kappabeta. Ciglitazone induced phosphorylation of PPARgamma through the MAP kinase pathway provides a potential regulatory mechanism for PPARgamma's physical interaction with p65, leading to inhibition of NF-kappabeta and subsequent apoptosis.
Ferroelectric Behaviour of Smectic Liquid Crystal (1977)

The temperature dependence of electric susceptibility is studied in L-p-decyloxybenzylidene-p'-amino-2methylbutyl-cinnamate (L-DOBAMBC) and a behaviour resembling the Curie-Weiss law is observed in a small temperature range at the smectic-A to smectic-C phase transition. The spontaneous polarization is estimated from the D-E hysteresis curve to be about 0.01 µ/cm2 at 80°C.
A bipolar integrated continuous-time filter with optimized dynamic range (1993)

In the design of integrated continuous-time filters it is often difficult to choose a proper integrator circuit because the relative merits of the different possibilities are little known. A thorough analysis of all the possible circuits is necessary. In this work, the design and an accurate analysis of the noise and distortion properties of one type of integrator, based on a tunable bipolar transconductor, are given. The analysis is used to optimize the dynamic range, and the results are verified by simulation and measurement. A fifth-order low-pass filter design and implementation are presented to illustrate the usefulness of the designed integrator.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Acoustic tweezers via sub–time-of-flight regime surface acoustic waves (2016)

Micrometer-scale acoustic waves are highly useful for refined optomechanical and acoustofluidic manipulation, where these fields are spatially localized along the transducer aperture but not along the acoustic propagation direction. In the case of acoustic tweezers, such a conventional acoustic standing wave results in particle and cell patterning across the entire width of a microfluidic channel, preventing selective trapping. We demonstrate the use of nanosecond-scale pulsed surface acoustic waves (SAWs) with a pulse period that is less than the time of flight between opposing transducers to generate localized time-averaged patterning regions while using conventional electrode structures. These nodal positions can be readily and arbitrarily positioned in two dimensions and within the patterning region itself through the imposition of pulse delays, frequency modulation, and phase shifts. This straightforward concept adds new spatial dimensions to which acoustic fields can be localized in SAW applications in a manner analogous to optical tweezers, including spatially selective acoustic tweezers and optical waveguides.
High-Throughput Quantification of Root Growth Using a Novel Image-Analysis Tool   (2009)

Measuring the dynamics of plant growth is fundamental to the understanding of plant development processes. This paper describes a high-throughput, automatic method to trace Arabidopsis (Arabidopsis thaliana) seedling roots grown on agarose plates. From the trace, additional software can quantify length, curvature, and stimulus response parameters such as onset of gravitropism. The method combines a particle-filtering algorithm with a graph-based method to trace the center line of a root. This top-down approach is robust to a variety of noise effects and is reasonably flexible across different image sets. The resulting tool requires minimal interaction from the user and is able to process long time-lapse sequences with user interaction only required on the first frame. The tool is described first, followed by its use on two sample data sets, one measuring root length and the other additionally analyzing the gravitropic response and curvature. The tool, RootTrace, is open source; both the program and source code will be available online.
Low-voltage light emitting devices in silicon IC technology (2005)

Low-voltage Si-LED operation can be achieved by fabricating devices with heavily doped n/sup +/p/sup +/junctions. Differences are observed between high-voltage avalanche and low-voltage field emission LED performance. The low-voltage devices exhibit a non-linear light intensity L vs. reverse current I relationship at low current levels, but a linear dependency at higher currents, compared to the linear behavior of avalanche devices at all current levels. Three regions of operation are identified for the low-voltage field emission LED's, namely L /spl prop/ I/sup 3/ at low currents, L /spl prop/ I/sup 2/ at medium currents and eventually L /spl prop/ 1 at higher currents. In the low-voltage non-linear region of operation, the shape of the emitted spectrum changes with reverse current. At low reverse current the field emission devices emit more long wavelength radiation than short wavelength radiation. As the reverse current increases, the short wavelength radiation increases relative to the long wavelength radiation, and at higher currents in the linear region of operation the ratio between long and short wavelength radiation remains constant.