gebhart/patrepeval huggingface dataset:
Extracellular glutathione peroxidase in human lung epithelial lining fluid and in lung cells (1996)

The epithelial cells of the lower respiratory tract are exposed to high levels of inhaled oxygen and other oxidants. We hypothesized that lung cells would secrete the antioxidant enzyme, extracellular glutathione peroxidase (eGPx), into epithelial lining fluid (ELF). To investigate this hypothesis, we used specific immunoprecipitations of GPx enzymes from ELF, specific immunoprecipitations of 75Se metabolically labeled proteins from lung cells in culture, and in situ hybridization, Northern blot, and reverse transcription-polymerase chain reaction (RT-PCR) analyses. Fifty-seven percent of ELF GPx activity was due to eGPx and 40% was due to cellular GPx (cGPx). Primary bronchial epithelial cells (BEC), primary alveolar macrophages (AM), and two human bronchial epithelial cell lines, BEP2D and A549, synthesized both eGPx and cGPx and secreted eGPx into the medium. Freshly isolated human AM and BEC expressed eGPx mRNA, while freshly isolated rabbit type 2 pneumocytes did not. In lung tissue, eGPx mRNA was found mainly in interstitial cells of tissue surrounding airways. It is concluded that more than half of GPx activity in BAL is due to eGPx, and that BEC, AM, and interstitial cells are potential sources of pulmonary eGPx.
Experimental Evaluation of Memory Management in Content-Centric Networking (2011)

Content-Centric Networking is a new communication architecture that rethinks the Internet communication model, designed for point-to-point connections between hosts, and centers it around content dissemination and retrieval. Most of the issues faced by the current IP infrastructure in terms of mobility management, security, scalability, which are accrued by today's Internet trends, find a natural solution in CCN shift from IP addresses to named data. In this paper we explore the impact of storage management on the performance of multiple applications sharing the same CCN infrastructure and we quantify the effectiveness of static storage partitioning and dynamic management techniques in providing service differentiation. To this purpose, we implement a set of storage management techniques in the open source CCNx prototype and perform extensive experiments in a real testbed under fairly realistic network conditions. Our experimental results allow to clarify the relation between CCN chunk-level caching and Quality of Experience (QoE) perceived by end users.
Suppressive Effect of Hyaluronan on Chondrocyte Apoptosis in Experimentally Induced Acute Ostaoarthritis in Dogs (2006)

Dogs receiving anterior cruciate ligament transection (ACLT) were treated with either intravenous (IV) or intraarticular (IA) administration of hyaluronan (HA), and differences in appearance of chondrocyte apoptosis of the stifle joint were investigated. Chondrocyte apoptosis was detected using flow cytometry as well as by staining with TdT-mediated dUTP nick end labeling (TUNEL). The percentage of apoptotic chondrocytes in dogs with ACLT was significantly higher than that in intact (non-ACLT) dogs. Dogs treated with IA or IV injection of HA after ACLT had fewer apoptotic chondrocytes than non-treated dogs after ACLT. It was suggested that ACLT-induced apoptosis of chondrocytes was suppressed by HA administration of either IA or IV.
Enterprise Liability: A Prescription for Health Care Reform? (1993)

A look at how the cost and quality of medical services in the United States would be affected by enterprise liability, a malpractice reform proposal that would 1) transfer liability in malpractice cases from the doctor to the patient's health care plan and 2) institute no-fault malpractice insurance.
Optical Phase Lock Loop Based Phased Array Transmitter for Optical Commmunications (2011)

We propose a novel deep space optical communication scheme, in which an integrated optical phased array (OPA) is used for both phase modulation and fine beam steering. In particular, an optical phase-locked loop (OPLL) based phased array with full electronic control over the phase is introduced and analyzed. The performance of such an array as a beam steering mechanism is evaluated and compared to realistic steering requirements for deep space applications. It is shown that an array with a high fill factor (>0.7) with about 300 elements per dimension is needed to meet these requirements. The effect of residual phase noise due to limited loop bandwidth is analyzed. Finally, the theory is validated by experimental results demonstrating successful beam steering using a two-element phased array.
Cationic Liposomes Containing Disulfide Bonds in Delivery of Plasmid DNA (1999)

Cationic liposomes are non-viral gene transfer vectors for in vitro and in vivo experiments. In the present studies, we investigated whether a disulfide linkage in a cationic lipid was reducible by cell lysate resulting in the release of plasmid DNA and enhanced gene transfection. We also investigated if the differences in transgene production were from differences in total amount of cellular associated plasmid DNA. We systematically compared the gene transfection of disulfide bond containing-cationic lipid, 1', 2'-dioleoyl-sn-glycero-3'-succinyl-2-hydroxyethyl disulfide ornithine conjugate (DOGSDSO), its non-disulfide-containing analog, 1', 2'-dioleyl-sn-glycero-3'-succinyl-1, 6-hexanediol ornithine conjugate (DOGSHDO), 1, 2-dioleoyl-3-trimethylammonium-propane (DOTAP). Two transgene reporter systems (i.e., luciferase and green fluorescent protein (GFP)) were used to address transgene transgene expression and transgene efficiency. Experiments with the luciferase expression plasmid resulted in transgene activity up to 11 times greater transgene production for the disulfide containing lipid in at least two different cell lines, COS 1 and CHO cells. When transgene expression was determined by GFP activity, DOGSDSO liposomes were four times greater than the non-disulfide lipid or positive control (DOTAP) liposomes. By quantifying nucleic acid uptake by flow cytometry it was also demonstrated that increase expression was not solely from an increase in cellular plasmid DNA accumulation. These results demonstrate that cationic lipids containing a disulfide linkage are a promising method for gene transfer.
Design of a microcode link editor (1980)

We developed a microcode link editor (microbinder) that supports a variety of different micromachines. The microbinder resolves symbolic label references within and between separately assembled microcode modules, allocates space for each module in control store, and constructs the control store load image and supporting tables. The microbinder also provides a number of other services called for by the special nature of micromachines. It supports microprogramming conventions at a low level to prevent misuse of the hardware, at an intermediate level to limit microfunctionality in certain environments, and at a high level to improve microcode maintainability. Details of these conventions can be defined by the user, in a symbolic language coordinated with engineering documentation. The microbinder was implemented in a high level language, which contributed to its timely delivery, flexibility, and dependability.
Multi-Task Learning of Gaussian Graphical Models (2010)

We present multi-task structure learning for Gaussian graphical models. We discuss uniqueness and boundedness of the optimal solution of the maximization problem. A block coordinate descent method leads to a provably convergent algorithm that generates a sequence of positive definite solutions. Thus, we reduce the original problem into a sequence of strictly convex ℓ∞ regularized quadratic minimization subproblems. We further show that this subproblem leads to the continuous quadratic knapsack problem, for which very efficient methods exist. Finally, we show promising results in a dataset that captures brain function of cocaine addicted and control subjects under conditions of monetary reward. 1.
The ion optics of a two grid electron-bombardment thruster (1976)

A detailed experimental investigation was performed to determine the ion-optical performance of an electron-bombardment ion thruster as a function of grid geometry changes. The results show that each geometrical grid parameter independently affects one aspect of ion-optical performance. These observations are used in developing a graphical technique to predict the ion-optical performance of an arbitrary ion source and grid geometry combination. The usefulness of this technique is demonstrated by comparing predicted ion-optical performance of the 30-cm diameter engineering model ion thruster with independent experimental determinations. Good agreement is shown between predicted and experimental results.
Extraction and Purification of Tetrodotoxin (1964)

フグ卵巣の水抽出液を加熱除タンパク後,イオン交換樹脂に吸着させることを骨子としたテトロドトキシンの新抽出法を考案した。この方法によれば少なくとも全一量の50%以上の毒を結晶状に得ることができる。また通常の再沈殿法で精製したテトロドトキシンにはアンヒドロエピテトロドトキシンが混在し,それを除去するにはピクラートを経て精製する必要がある。この精製テトロドトキシンを用いれば,臭化水素酸塩を結晶として得ることができる。
Synthesis of Base-Free Cationic Zirconium Methyl and Benzyl Complexes. The Crystal and Molecular Structure of {C5H3(SiMe3)2-1,3}2ZrMe(.mu.-Me)B(C6F5)3 (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of Base-Free Cationic Zirconium Methyl and Benzyl Complexes. The Crystal and Molecular Structure of {C5H3(SiMe3)2-1,3}2ZrMe(.mu.-Me)B(C6F5)3Manfred Bochmann, Simon J. Lancaster, Michael B. Hursthouse, and K. M. Abdul MalikCite this: Organometallics 1994, 13, 6, 2235–2243Publication Date (Print):June 1, 1994Publication History Published online1 May 2002Published inissue 1 June 1994https://pubs.acs.org/doi/10.1021/om00018a017https://doi.org/10.1021/om00018a017research-articleACS PublicationsRequest reuse permissionsArticle Views538Altmetric-Citations193LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Simultaneous Sensing and Transmission in Cognitive Radio (2014)

In cognitive radio, spectrum sensing is used to find the white spectrum or protect the primary user from interference caused by the secondary user (SU). There are two conventional spectrum sensing approaches: quiet and active. However, these conventional approaches have several problems. In quiet sensing, the quiet period degrades the SU capacity. With active sensing, the SU capacity is also degraded by the need for additional resource consumption and the mismatch in feedback information. In order to mitigate these problems, the structure of simultaneous PU sensing and data transmission is introduced. This structure is equipped with antenna isolation and self-interference cancellation in which the communication and the sensing radios are already assumed to be significantly isolated. This approach is designed so that the SU transmitter can sense PU signals and transmit data signals at the same time by dividing its spatial resources. Expanding on this work, we propose a concept of "TranSensing" which adaptively uses spatial resource according to the surrounding environments. To effectively use TranSensing, we propose a two-stage algorithm (TSA). Finally, the impact of residual interference on TranSensing is investigated. Simulation results show that TranSensing with TSA enhances the SU capacity over the conventional quiet or active sensing.
Coordinate Signaling by Src and p38 Kinases in the Induction of Cortical Cataracts (2004)

Activation of both Src and p38 kinases lead to the induction of cataract.
Substitiution reaction of naphtho[2,1-b]thiophen (1969)

The nitration of naphtho[2,1-b]thiophen has been shown to give the 2-nitro-derivative as the sole product. This has been proved by reduction, acetylation, and desulphurisation to the known N-acetyl-2-(1-naphthyl)ethylamine. Formylation, acylation, lithiation, and mercuration also take place in the 2-position. Bromination gives a mixture of 2-bromo- and 2,5-dibromo-naphtho[2,1-b]thiophen.
Regulation of MAO-A and MAO-B Gene Expression (2004)

MAO A and B genes are made of 15 exons with identical exon-intron organization. They are located on X-chromosome organized in opposite direction, tail to tail with 24 kb apart. Both promoters are GC-rich and regulated by transcription factor Sp1. However, they have distinctly different features. MAO B gene, but not MAO A gene, has TATA box. MAO B promoter contains two clusters of overlapping Sp1 sites, the CACCC repressor element. Transcription factors Sp1 and Sp4 can activate MAO B promoter activity through the proximal cluster of Sp1 sites and its activation can be repressed by the over-expression of Sp3 and a related family member, BTEB2. Decreased methylation and transcription repressor Sp3 upregulate human MAO B, but not MAO A, gene expression during Caco-2 differentiation. MAO B, but not MAO A gene, could be activated by PMA (phorbol 12-myristate 13-acetate) by protein kinase C, MAPkinase signal transduction pathway involves cJun and Egr-1. The differences in MAO A and B gene regulation may explain the different tissue-specific expression and functions of these two important isoenzymes.
Contact-dependent cytopathogenic mechanisms of Trichomonas vaginalis (1985)

The cytopathogenic mechanisms of Trichomonas vaginalis have been debated since the 1940s. We examined the following three proposed pathogenic mechanisms: contact-dependent extracellular killing, cytophagocytosis, and extracellular cytotoxins. Serial observations of Chinese hamster ovary (CHO) cell monolayers exposed to trichomonads revealed that (i) trichomonads form clumps, (ii) the clumps adhere to cells in culture, and (iii) monolayer destruction occurs only in areas of contact with T. vaginalis. Kinetic analysis of target cell killing by trichomonads revealed that the probability of CHO cell death was related to the probability of contact with T. vaginalis, supporting the observation by microscopy that trichomonads kill cells only by direct contact. Simultaneous studies of 111indium oxine label release from CHO cells and trypan blue dye exclusion demonstrated that T. vaginalis kills target cells without phagocytosis. Filtrates of trichomonad cultures or from media in which trichomonads were killing CHO cells had no effect on CHO cell monolayers, indicating that trichomonads do not kill cells by a cell-free or secreted cytotoxin. The microfilament inhibitor cytochalasin D (10 micrograms/ml) inhibited trichomonad killing of CHO cell monolayers by 80% (P less than 0.0001). In contrast, the microtubule inhibitor vinblastine (10(-6) M) caused only 17% inhibition of trichomonad destruction of CHO cell monolayers (P less than 0.020), whereas colchicine (10(-6) M) had no effect. T. vaginalis kills target cells by direct contact without phagocytosis. This event requires intact trichomonad microfilament function; microtubule function appears not to be essential.
Paulino de Nola o la diplomacia antipriscilianista (Comentario a su epístola 23) (1988)

This paper presents information on the evolution of sets of cloned heifers of Holstein breed in comparison to that of control heifers derived from artificial insemination (AI) in the same farm, as well as data on a set of cloned bulls and their semen characteristics. Preliminary observations on a group of calves sired by a cloned bull and offspring of cloned females are reported. Mean birth weight in the clone group (50 females) was statistically higher than that of 68 contemporary female controls obtained by AI (49.27 +/- 10.98 vs. 40.57 +/- 5.55 kg, respectively, p < 0.05). Growth rate was within normal values for Holstein heifers (from 0.7 to 0.8 kg/day) and daily gain was not influenced by the high or low birth weight of clones. Within animals of the same clone, variability of daily gain was reduced compared to their control counterparts. Semen production from three cloned bulls was within the parameters expected for young bull of the same age. A direct comparison of morphological analysis was made between the frozen thawed semen of the donor bull and of his three clones collected at the same age. The overall semen picture appeared within acceptable limits and the clones presented similar percentages of sperm abnormalities (80% of morphologically normal spermatozoa) as the donor. These preliminary results suggest no deleterious effect of cloning on the semen picture of cloned sires. Frozen semen from one clone bull was used for an AI trial, resulting in 65% pregnancies, 25 live calves were naturally delivered. Concerning the offspring of both female and male clones, the phenotypical and clinical observation of the calves in the first week of age did not reveal any clinical abnormality, suggesting that the deviations observed in clones are not transmitted to the progeny.
Subfield-Subcodes of Generalized Toric codes (2016)

We study subfield-subcodes of Generalized Toric (GT) codes over $\mathbb{F}_{p^s}$. These are the multidimensional analogues of BCH codes, which may be seen as subfield-subcodes of generalized Reed-Solomon codes. We identify polynomial generators for subfield-subcodes of GT codes which allows us to determine the dimensions and obtain bounds for the minimum distance. We give several examples of binary and ternary subfield-subcodes of GT codes that are the best known codes of a given dimension and length.
Schwann Cells Can Be Reprogrammed to Multipotency by Culture (2011)

Adult neural crest related-stem cells persist in adulthood, making them an ideal and easily accessible source of multipotent cells for potential clinical use. Recently, we reported the presence of neural crest-related stem cells within adult palatal ridges, thus raising the question of their localization in their endogenous niche. Using immunocytochemistry, reverse transcription-polymerase chain reaction, and correlative fluorescence and transmission electron microscopy, we identified myelinating Schwann cells within palatal ridges as a putative neural crest stem cell source. Palatal Schwann cells expressed nestin, p75(NTR), and S100. Correlative fluorescence and transmission electron microscopy revealed the exclusive nestin expression within myelinating Schwann cells. Palatal neural crest stem cells and nestin-positive Schwann cells isolated from adult sciatic nerves were able to grow under serum-free conditions as neurospheres in presence of FGF-2 and EGF. Spheres of palatal and sciatic origin showed overlapping expression pattern of neural crest stem cell and Schwann cell markers. Expression of the pluripotency factors Sox2, Klf4, c-Myc, Oct4, the NF-κB subunits p65, p50, and the NF-κB-inhibitor IκB-β were up-regulated in conventionally cultivated sciatic nerve Schwann cells and in neurosphere cultures. Finally, neurospheres of palatal and sciatic origin were able to differentiate into ectodermal, mesodermal, and endodermal cell types emphasizing their multipotency. Taken together, we show that nestin-positive myelinating Schwann cells can be reprogrammed into multipotent adult neural crest stem cells under appropriate culture conditions.
Space-time adaptive monopulse processing (1998)

Contents 1 Introduction 1 2 Background 2 2.1 Space-Time Processing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2.2 Monopulse . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 2.2.1 Monopulse with Arrays . . . . . . . . . . . . . . . . . . . . . . . . . . 10 2.2.2 Conventional and Adaptive Monopulse . . . . . . . . . . . . . . . . . 12 3 Proposed Research 15 3.1 Space/Fast-Time Monopulse Processing . . . . . . . . . . . . . . . . . . . . . 16 3.2 Combined TSI and MSC Processing . . . . . . . . . . . . . . . . . . . . . . . 20 3.3 Simulation Results . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25 3.3.1 Sum and Difference Patterns . . . . . . . . . . . . . . . . . . . . . . . 26 3.3.2 Angle Estimation in TSI and Jamming . . . . . . . . . . . . . . . . . 30 3.3.3 Combined MSC, TSI and mainbeam Jamming . . . . . . . . . . . . . 33 4 Work Completed 35 5 Remaining Work 35 6 Contributions 37 Refe
A 2.5-mA threshold current operation and 5-Gbit/s zero- bias current modulation of 1.5-μm MQW-DFB laser diodes (1990)

High speed modulation without bias current is highly attractive since driving circuits are markedly simplified. Laser diodes (LDs) with low threshold current Ith are required for high speed zero-bias modulation because of small lasing delay time τd. Derry et al.1
Proof of Delivery of Digital Assets Using Blockchain and Smart Contracts (2018)

There is an immense need of a proof of delivery (PoD) of today's digital media and content, especially those that are subject to payment. Current PoD systems are mostly centralized and heavily dependent on a trusted third party (TTP) especially for payment. Such existing PoD systems often lack security, transparency, and visibility, and are not highly credible, as the TTP can be subject to failure, manipulation, corruption, compromise, and hacking. In this paper, we propose a decentralized PoD solution for PoD of digital assets. Our solution leverages key features of blockchain and Ethereum smart contracts to provide immutable and tamper-proof logs, accountability, and traceability. Ethereum smart contracts are used to orchestrate and govern all interactions and transactions including automatic payments in Ether cryptocurrency between customers, digital-content provider, and the file server hosting the digital content. All entities are incentivized to act honestly, and our solution has a mechanism to handle dispute if arisen among participants. The solution has an off-chain secure download phase involving the file server and customers. Moreover, our solution leverages the benefits of interplanetary file system to store the agreed upon terms and conditions between the smart contract actors. A security analysis of our proposed system has been provided. The full code of the smart contract has been publicly made available on Github.
Multisensory Integration (2008)

Multisensory integration in humans is thought to be essentially a brain phenomenon, but theories are silent as to the possible involvement of the peripheral nervous system. We provide evidence that this approach is insufficient. We report novel tactile-auditory and tactile-visual interactions in humans, demonstrating that a facilitating sound or visual stimulus that is exactly synchronous with an excitatory tactile signal presented at the lower leg increases the peripheral representation of that excitatory signal. These results demonstrate that during multisensory integration, the brain not only continuously binds information obtained from the senses, but also acts directly on that information by modulating activity at peripheral levels. We also discuss a theoretical framework to explain this novel interaction.