gebhart/patrepeval huggingface dataset:
Levels of Processing and Memory Awareness when Recognising Own-race versus Other-race Faces: Implications for Eye-witness Memory (2013)

The study employed the remember-know paradigm to investigate levels-of-processing effects in recognition memory for same-versus other-race faces. It was predicted that deeper processing would benefit accuracy in recognition and remembering for both own- and other-race faces. Moreover, the Cross-Race Bias (CRB) would be evident with participants more accurately recognizing faces of their own race than faces of another race. No interaction between the 2 variables was expected. Deeper processing benefited accurate remembering only. The CRB was evident with same-race faces being accurately recognised more than other-race faces, and more remember and know false positives being given to other-race faces. No interaction effect was found. The results do not support the depth of processing hypothesis for the CRB and have implications for the assumption that richer encoding could lead to a decrease in CRB by minimising false positives. Thus, in eyewitness memory richer encoding opportunities do not necessarily lead to less false cross-race identifications and care should be taken when dealing with those kinds of identifications.
Virus Inactivation by Solvent/Detergent Treatment and the Manufacture of SD‐Plasma (1998)

Solvent/Detergent (SD) is an extraordinarily effective means for eliminating enveloped viruses from plasma and plasma products. The safety margin suggested by the rapid and complete kill of enveloped viruses observed in the laboratory has been confirmed repeatedly by groups worldwide and by thirteen years of routine clinical use encompassing an estimated 35 million doses of a wide variety of products. Throughout this time, there has not been a single documented case of enveloped virus transmission by an SD-treated product. This record of safety spawned the development of SD-treated plasma as a substitute for fresh frozen plasma (FFP) and has encouraged the adoption of SD for the treatment of non-blood products such as monoclonal antibodies and those derived from recombinant DNA procedures. This review summarizes the use of SD treatment, including its use in combination with other viral elimination procedures, and also summarizes Vitex's initial experience in the manufacture of SD-Plasma, recently licensed by the U.S. FDA.
Triple-threshold static power minimization technique in high-level synthesis using 90nm MTCMOS technology (2007)

As CMOS System-on-Chips approach the limits of power dissipation, static power has become dominant in a circuit’s total power dissipation. The static power is increasing exponentially as technology nodes shrink and is projected to exceed the dynamic power within the near future. Techniques that use the multi-threshold CMOS (MTCMOS) technology have been developed to reduce static power effectively. In this thesis, a novel triple-threshold static power minimization technique in high-level synthesis has been developed using the 90nm MTCMOS technology. Using static timing analysis, the optimal partitioning of gates with three different threshold voltages is determined via iterative analysis. The proposed triple-threshold technique has been applied to optimize several benchmark circuits, and the results show an average saving in static power close to 90% compared to un-optimized LVT designs. For all designs tested, the triple-threshold technique has produced designs with lower static power compared to a dual-threshold technique.
Serological titres to <i>Leptospira fainei</i> serovar hurstbridge in human sera in Australia (1998)

A set of 723 diagnostic sera from human patients, submitted for the microscopic agglutination test (MAT) for antibodies to a group of 6 leptospiral serovars, was also tested by MAT for antibodies to the recently-discovered Leptospira fainei serovar hurstbridge. MAT titres of > or = 128 to serovar hurstbridge were detected in 13.4% of these sera, and titres of > or = 512 in 7.2%. In contrast, none of 62 sera obtained from a control population of laboratory staff gave titres of > or = 128. The difference between the number of titres of > or = 128 given by the two groups of sera was highly significant (P < 0.01). The titres observed may have been due to cross-reactions with other leptospiral serovars, but this could not be demonstrated. An alternative explanation is that serovar hurstbridge is present in the human population.
Formation of adriamycin-DNA adducts<i>in vitro</i> (1994)

Adriamycin is known to induce the formation of adducts with DNA when reacted under in vitro transcription conditions. The factors affecting the extent of adduct formation were examined in order to establish the critical components and optimal conditions required for the reaction, and to gain insight into the nature of the DNA-adduct complex. There was a strong dependence on reaction temperature (with a 40-fold increase of adducts at 40-50 degrees C compared to 10 degrees C), pH (maximum adducts at pH 7), but little dependence on the oxygen level. There was an absolute requirement for a reducing agent, with adducts detected with DTT, beta-mercaptoethanol and glutathione, maximal adducts were formed at high levels of DTT (5-10 mM). Adducts were also formed with a xanthine oxidase/NADH reducing system, with increasing amounts of adducts detected with increasing NADH; no adducts were detected in the absence of either the enzyme or NADH. Of fourteen derivatives studied, only four yielded a similar extent of adduct formation as adriamycin; there was no absolute requirement for a carbonyl at C13 or hydroxyl at C14. Adducts were also observed with ssDNA but required a longer reaction time compared to dsDNA. The sequence specificity of adduct formation with ssDNA was examined using a primer-extension assay; almost all adducts were associated with a guanine residue. Overall, the results are consistent with a two-step reaction mechanism involving reductive activation of adriamycin, with the activated species then reacting with the guanine residues of either dsDNA or ssDNA.
Inhibition of Ser/Thr Phosphatases Induces Capacitation-associated Signaling in the Presence of Src Kinase Inhibitors (2010)

Signaling events leading to mammalian sperm capacitation rely on activation/deactivation of proteins by phosphorylation. This cascade includes soluble adenylyl cyclase, an atypical bicarbonate-stimulated adenylyl cyclase, and is mediated by protein kinase A and the subsequent stimulation of protein tyrosine phosphorylation. Recently, it has been proposed that the capacitation-associated increase in tyrosine phosphorylation is governed by Src tyrosine kinase activity. This conclusion was based mostly on the observation that Src is present in sperm and that the Src kinase family inhibitor SU6656 blocked the capacitation-associated increase in tyrosine phosphorylation. Results in the present manuscript confirmed these observations and provided evidence that these inhibitors were also able to inhibit protein kinase A phosphorylation, sperm motility, and in vitro fertilization. However, the block of capacitation-associated parameters was overcome when sperm were incubated in the presence of Ser/Thr phosphatase inhibitors such as okadaic acid and calyculin-A at concentrations reported to affect only PP2A. Altogether, these data indicate that Src is not directly involved in the observed increase in tyrosine phosphorylation. More importantly, this work presents strong evidence that capacitation is regulated by two parallel pathways. One of them requiring activation of protein kinase A and the second one involving inactivation of Ser/Thr phosphatases.
Metabolic Enzymes Enjoying New Partnerships as RNA-Binding Proteins (2015)

In the past century, few areas of biology advanced as much as our understanding of the pathways of intermediary metabolism. Initially considered unimportant in terms of gene regulation, crucial cellular fate changes, cell differentiation, or malignant transformation are now known to involve 'metabolic remodeling' with profound changes in the expression of many metabolic enzyme genes. This review focuses on the recent identification of RNA-binding activity of numerous metabolic enzymes. We discuss possible roles of this unexpected second activity in feedback gene regulation ('moonlighting') and/or in the control of enzymatic function. We also consider how metabolism-driven post-translational modifications could regulate enzyme-RNA interactions. Thus, RNA emerges as a new partner of metabolic enzymes with far-reaching possible consequences to be unraveled in the future.
Global Burden of Influenza as a Cause of Cardiopulmonary Morbidity and Mortality (2014)

Severe acute respiratory infections, including influenza, are a leading cause of cardiopulmonary morbidity and mortality worldwide. Until recently, the epidemiology of influenza was limited to resource-rich countries. Emerging epidemiological reports characterizing the 2009 H1N1 pandemic, however, suggest that influenza exerts an even greater toll in low-income, resource-constrained environments where it is the cause of 5% to 27% of all severe acute respiratory infections. The increased burden of disease in this setting is multifactorial and likely is the result of higher rates of comorbidities such as human immunodeficiency virus, decreased access to health care, including vaccinations and antiviral medications, and limited healthcare infrastructure, including oxygen therapy or critical care support. Improved global epidemiology of influenza is desperately needed to guide allocation of life-saving resources, including vaccines, antiviral medications, and direct the improvement of basic health care to mitigate the impact of influenza infection on the most vulnerable populations.
An interaction problem of distributed generators installed in a MicroGrid (2004)

This paper investigates an interaction problem that might be induced from various kinds of distributed generators installed in a MicroGrid. One of the most important features of MicroGrid is islanding operation. MicroGrid does not include large central generators and all distributed small generators have to share all loads existing in the MicroGrid. In this case, undesirable mutual oscillation problem might appear when MicroGrid goes into islanding mode. In this paper, MicroGrid itself and several types of distributed generator are modeled by using Matlab/Simulink. A typical case is simulated and examined by using the developed model.
Intermediate Filaments and Vesicular Membrane Traffic: The Odd Couple's First Dance? (2005)

During the last two decades, much attention has been focused on the regulation of membrane traffic by the actin and microtubule cytoskeletal networks. Their dynamic and polarized behavior and associated motors provide a logical framework from which architectural and movement cues can be communicated to organelles. The study of these cytoskeletal systems has been greatly aided by pharmacological agents. In contrast, intermediate filaments (IFs) have largely been neglected as a potential player in membrane traffic, both because a comprehensive pharmacology to perturb them does not exist and because they lack the intrinsic polarity and specific motors that make the other cytoskeletal systems attractive. In this review, we will discuss evidence suggesting that IFs may play roles in controlling organelle positioning and in membrane protein targeting. Furthermore, we will discuss potential mechanisms by which IFs may regulate the localization and function of organelles.
The dismutation of aldehydes by a bacterial enzyme. (1983)

Formaldehyde-resistant Pseudomonas putida F61 isolated from a soil sample showed high activities of formaldehyde dehydrogenase (EC 1.2.1.1) and a specific enzyme catalyzing the dismutation of formaldehyde to form methanol and formate. The latter enzyme, given the trivial name of formaldehyde dismutase, was purified to electrophoretic homogeneity from a cell-free extract of P. putida F61. The enzyme was a tetramer with a molecular weight of approximately 2.2 x 105, and an isoelectric point of 4.8. The enzyme catalyzed the stoichiometric dismutation of formaldehyde and acetaldehyde to form a half mol of each of the corresponding alcohol and acid without addition of an electron acceptor, but it did not catalyze the dismutation of propionaldehyde, butyraldehyde and so on. The apparent Km for formaldehyde was found to be 350mM. One of the most unique properties of the enzyme was the catalytic activity of crossdismutation between two different aldehydes, such as formaldehyde/acetaldehyde, formaldehyde/propionaldehyde, and so on.
<i>In Vitro</i> Tests for Aerosol Deposition. I: Scaling a Physical Model of the Upper Airways to Predict Drug Deposition Variation in Normal Humans (2011)

A new in vitro test method is described to predict the median and range of aerosol drug deposition seen in vivo. The method produced an IVIVC that was consistent with 1:1 predictions of total lung deposition from a marketed powder inhaler in trained normal adults.
Highly water-soluble three-redox state organic dyes as bifunctional analytes (2016)

Common organic dyes show three stable redox states, offering an alternative to questionable vanadium for the implementation of redox-flow batteries.
Optimizing bioavailability of oral administration of small peptides through pharmacokinetic and pharmacodynamic parameters: The effect of water and timing of meal intake on oral delivery of Salmon Calcitonin (2008)

0.8 mg sCT with 50 ml of water taken 30 and 60 minutes prior to meal time resulted in optimal pharmacodynamic and pharmacokinetic parameters. The data suggest that this novel oral formulation may have improved absorption and reduction of bone resorption compared to that of the nasal form.
Delay in Notice of Tort Claim against a Government Agency (1971)

Despite an onslaught of criticism and a rationale predicated on the discredited doctrine of Divine Right of Kings, the rule of sovereign immunity still exists in many states. As a result of this anachronism, municipalities and other subdivisions of state government have continued to escape liability for the tortious conduct of their agents. This situation has persisted despite a tendency by the courts to restrict rather than extend the principle of immunity. Statutory enactments such as short term notice provisions applied against potential plaintiffs by states and their subdivisions, when strictly construed by the courts, have had the effect of a short term statute of limitation. The result of such construction is the exacerbation of the fiction of immunity.
Ranolazine Stimulates Glucose Oxidation in Normoxic, Ischemic, and Reperfused Ischemic Rat Hearts (1996)

Beneficial effects of ranolazine in cardiac ischemia/reperfusion may be due, at least in part, to a stimulation of glucose oxidation and a reduction in FA oxidation, allowing improved ATP/O2 and reduction in the buildup of H+, lactate, and harmful fatty acyl intermediates.
<i>soc-2</i> encodes a leucine-rich repeat protein implicated in fibroblast growth factor receptor signaling (1998)

Activation of fibroblast growth factor (FGF) receptors elicits diverse cellular responses including growth, mitogenesis, migration, and differentiation. The intracellular signaling pathways that mediate these important processes are not well understood. In Caenorhabditis elegans, suppressors of clr-1 identify genes, termed soc genes, that potentially mediate or activate signaling through the EGL-15 FGF receptor. We demonstrate that three soc genes, soc-1, soc-2, and sem-5, suppress the activity of an activated form of the EGL-15 FGF receptor, consistent with the soc genes functioning downstream of EGL-15. We show that soc-2 encodes a protein composed almost entirely of leucine-rich repeats, a domain implicated in protein-protein interactions. We identified a putative human homolog, SHOC-2, which is 54% identical to SOC-2. We find that shoc-2 maps to 10q25, shoc-2 mRNA is expressed in all tissues assayed, and SHOC-2 protein is cytoplasmically localized. Within the leucine-rich repeats of both SOC-2 and SHOC-2 are two YXNX motifs that are potential tyrosine-phosphorylated docking sites for the SEM-5/GRB2 Src homology 2 domain. However, phosphorylation of these residues is not required for SOC-2 function in vivo, and SHOC-2 is not observed to be tyrosine phosphorylated in response to FGF stimulation. We conclude that this genetic system has allowed for the identification of a conserved gene implicated in mediating FGF receptor signaling in C. elegans.
Prenatal diagnosis of X‐linked hypohidrotic ectodermal dysplasia by linkage analysis (1990)

Prenatal diagnosis of X-linked hypohidrotic ectodermal dysplasia was previously performed by the direct histological analysis of fetal skin obtained by late second trimester fetoscopy. The recent gene mapping of the locus for the disorder to the region of Xq11-21.1 now permits the indirect prenatal diagnosis of the disorder by the method of linkage analysis, based on closely linked marker loci, during the first trimester of pregnancy. We report the prenatal diagnosis of a male fetus with a high probability of the disorder by a linkage analysis utilizing restriction fragment length polymorphisms at the DXS159, PGK1, and DXS72 loci, from a DNA sample obtained by a chorionic villus biopsy at 9 weeks gestation. After further counseling, the pregnancy was terminated but the diagnosis could not be confirmed by histological analysis, even though analysis of skin samples by light and electron microscopy showed lack of hair germs, primary dermal ridges, and sweat gland primordia, due to the early developmental stage of the fetus. The use of DNA-based linkage analysis now offers the opportunity for an earlier diagnosis of X-linked hypohidrotic ectodermal dysplasia by a method other than fetal skin sampling. However, families must also fully understand the present limitations of the method prior to undertaking the procedure.
Iterative algorithm for determining optimal beam profiles in a three-dimensional space (1999)

A new, to our knowledge, iterative algorithm for achieving optimization of beam profiles in a three-dimensional volume is presented. The algorithm is based on examining the region of interest at discrete plane locations perpendicular to the propagation direction. At each such plane an intensity constraint is imposed within a well-defined transverse spatial region of interest, whereas the phase inside that region as well as the complex amplitude outside the region is left unchanged from the previous iteration. Once the optimal solution is found, the mask that generates the desired distribution can be readily implemented with a planar diffractive optical element such as a computer-generated hologram. Several computer simulations verified the utility of the proposed approach.
Optimization of genistein solubilization by κ-carrageenan hydrogel using response surface methodology (2013)

κ-Carrageenan was explored to improve genistein solubility by matrix retention. The corresponding maximum value in the efficiency of retention (Re) (50.48 mg/100 mg) was achieved when variables were set as: pH 4.76, temperature 52.12 °C and genistein concentration 0.27 mg/mL. The coefficient of determination (R2) of the response surface regression model presented in this study was 0.9848. The evidences from XRD, DSC and FT-IR attested the amorphous form of genistein in hydrogel matrix. Importantly, the solubility of genistein in hydrogel amorphous form (16.84–34.42 μg/mL) was much higher than that of its free crystalline form (1.89–6.09 μg/mL) over 30–90 °C.
A New Series of Organoboranes. III. Some Reactions of 1,2-Dicarbaclovododecaborane(12) and its Derivatives (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA New Series of Organoboranes. III. Some Reactions of 1,2-Dicarbaclovododecaborane(12) and its DerivativesT. L. Heying, J. W. Ager Jr., S. L. Clark, R. P. Alexander, S. Papetti, J. A. Reid, and S. I. TrotzCite this: Inorg. Chem. 1963, 2, 6, 1097–1105Publication Date (Print):December 1, 1963Publication History Published online1 May 2002Published inissue 1 December 1963https://pubs.acs.org/doi/10.1021/ic50010a004https://doi.org/10.1021/ic50010a004research-articleACS PublicationsRequest reuse permissionsArticle Views1080Altmetric-Citations113LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Medienpädagogische Fortbildungsangebote für Erzieherinnen (1994)

Durch schriftliche und telefonische Anfragen wurde 1991 das medienpädagogische Fortbildungsangebot für Erzieherinnen ermittelt. Angefragt wurden:
On the Aggregation of Tin in SnO Composite Glasses Caused by the Reversible Reaction with Lithium (1999)

We show that the reaction mechanism in , and Li/SnO cells is common. During the first discharge, the oxygen bonded to tin (as SnO) reacts with lithium to give metallic tin (which can be present as clusters of a few atoms) and lithia. The tin reacts with further lithium to the composition limit of . During charge the Li is removed from the lithium‐tin alloy. The other components of the glass are inert with respect to lithium, and we call the atoms which make up these phases "spectator atoms." Using X‐ray diffraction (XRD) and electrochemical methods, we show that size of the initial tin regions which form is inversely proportional to the spectator:Sn atom ratio. However, during cycling, all of these materials show the subsequent aggregation of the tin atoms into clusters which grow with cycle number until they reach a saturated size. The final cluster size is larger for materials with smaller X:Sn ratio. We propose a speculative model, which predicts the saturated Sn cluster size, as a function of the spectator:Sn ratio. © 1999 The Electrochemical Society. All rights reserved.
Characteristics of Fusion Products between Pleurotus ostreatus and Pleurotus florida Following Interspecific Protoplast Fusion (1984)

Interspecific heterokaryons were obtained between auxotrophic mutants of Pleurotus ostreatus and Pleurotus florida by polyethylene induced fusion of somatic protoplasts. The fusion products produced colonies of dense growing mycelium after 10-14 days culture on hypertonic Mushroom Minimal Medium. When they were transferred to Mushroom Minimal Medium plates, the sectors showed normal vegetative morphology but the colonies of irregular shape varied in growth rate. All of the colonies produced fruit body of normal pilei. Some heterokaryon colonies bearing none or only a small amounts of basidiospores were isolated. Fusion products, generally, gave higher basidiocarp yields than the parents.