gebhart/patrepeval huggingface dataset:
Detection and Localization of Single LysM-Peptidoglycan Interactions (2008)

The lysin motif (LysM) is a ubiquitous protein module that binds peptidoglycan and structurally related molecules. Here, we used single-molecule force spectroscopy (SMFS) to measure and localize individual LysM-peptidoglycan interactions on both model and cellular surfaces. LysM modules of the major autolysin AcmA of Lactococcus lactis were bound to gold-coated atomic force microscopy tips, while peptidoglycan was covalently attached onto model supports. Multiple force curves recorded between the LysM tips and peptidoglycan surfaces yielded a bimodal distribution of binding forces, presumably reflecting the occurrence of one and two LysM-peptidoglycan interactions, respectively. The specificity of the measured interaction was confirmed by performing blocking experiments with free peptidoglycan. Next, the LysM tips were used to map single LysM interactions on the surfaces of L. lactis cells. Strikingly, native cells showed very poor binding, suggesting that peptidoglycan was hindered by other cell wall constituents. Consistent with this notion, treatment of the cells with trichloroacetic acid, which removes peptidoglycan-associated polymers, resulted in substantial and homogeneous binding of the LysM tip. These results provide novel insight into the binding forces of bacterial LysMs and show that SMFS is a promising tool for studying the heterologous display of proteins or peptides on bacterial surfaces.
Intervention Effectiveness in Reducing Prejudice Against Transsexuals (2013)

The transgender community encounters pervasive prejudice, discrimination, and violence, yet social science literature lacks research that focuses on reduction of antitransgender prejudice. This experimental study examined the effectiveness of three interventions aimed at decreasing negative attitudes toward transsexuals, correcting participants’ beliefs in myths about transsexuality, and reducing their predicted discriminatory behaviors. Results revealed a significant decrease in negative attitudes and beliefs in myths. However, no individual intervention proved more effective than the others. The interventions led to no change in predicted discriminatory behaviors.
Similarities and Differences of Low Salinity Polymer and Low Salinity LPS (Linked Polymer Solutions) for Enhanced Oil Recovery (2014)

Linked polymer solution (LPS) is nano-size particles made of hydrolyzed polyacrylamide (HPAM) cross-linked with aluminum citrate. The propagation of LPS has been compared to non-cross-linked polymers at low brine salinity condition. The possible differences in properties and potentials for oil recovery have been investigated using water-wet and intermediate-wet cores. The target oil for polymer flooding (PF) is assumed to be the portion of the reservoir that has been bypassed by water during waterflooding and not the residual oil saturation in flooded zones. Our recent studies have shown that a positive synergy can be obtained by combining low salinity and PF. It has been claimed in the literature that cross-linking polymer such as colloidal dispersion gels (colloidal dispersion gels (CDG), micron-size aggregates) or LPS (nano-size particles) would extend the application of polymers to also include change in residual oil saturation. The results of this study indicated higher pressure buildup when low salinity LPS was propagated through brine saturated cores compared to low salinity polymer solution. The pressure buildup was even stronger for high salinity LPS injection. In two phase flow experiments, both polymer and LPS under low salinity condition, showed approximately similar propagation and oil recovery potential when injected into water-wet and intermediate-wet cores.
Phase-sensitive reflection technique for characterization of a Fabry–Perot interferometer (2000)

Using a radio frequency coherent modulation and demodulation technique, we explicitly measure both the amplitude and the phase response of Fabry-Perot interferometers in reflection. This allows us to differentiate clearly between overcoupled and undercoupled cavities and allows a detailed measurement of the full width at half-maximum, the free spectral range, and the finesse of the cavities.
Scaling the Artificial Polariton Bandgap at Infrared Frequencies Using Indium Tin Oxide Nanorod Arrays (2016)

Artificial polariton bandgaps at infrared frequencies are investigated by exploiting the strong coupling of electromagnetic waves with induced electric dipoles in two‐dimensional (2D) indium tin oxide nanorod arrays (ITO‐NRAs). The electric dipoles originate from the collective oscillations of free electrons within the individual ITO nanorods undergoing plasmonic resonance. Controlling the near‐field interactions among the neighboring electric dipoles allows for manipulation of the collective polariton modes that are manifested as a polariton bandgap. A theoretical model is developed to understand the coupled phenomena underlying the unique characteristics of plasmon–polariton bandgaps. With high‐degree geometric control of the ITO‐NRAs, it is experimentally demonstrated that reducing the spacing between ITO nanorods in a square array strengthens the near‐field interactions and thus results in a redshift as well as broadening of the polariton bandgap. Furthermore, arranging ITO‐NRAs in a rectangular lattice breaks the symmetry with respect to the principle axis, which leads to a splitting of the collective polariton modes owing to the competition between the quasi‐longitudinally and quasi‐transversely coupled plasmon–polariton modes. The work highlights the use of a classical dipole coupling method for scaling polariton bandgaps to the infrared in artificial plasmonic lattices, thereby offering a new design dimension for infrared sensing, absorbers, and optical communications.
Synthesis and evaluation of the anti-inflammatory effects of niflumic acid lipophilic prodrugs in brain edema. (1996)

Five new lipophilic prodrugs of the non-steroidal anti-inflammatory drug, niflumic acid (Nifluril, CAS 4394-00-7), were synthetized and evaluated on the experimental brain edema (injection of phospholipase A2). The effect of these drugs in comparison with dexamethasone which elicits a marked effect on clinical and experimental brain edema was evaluated. Niflumic acid was vectorised by cholesterol, hexadecanol and by three 1,3-diacylglycerols. The anti-inflammatory activity of these compounds on experimental brain edema was evaluated by determination of the prostaglandin E2 (PGE2) brain tissue concentration. Niflumic acid reduced the prostaglandin E2 production more significantly than dexamethasone. Niflumic acid prodrug forms (1,3-dihexadecanoyl-2-[2-[3-(trifluoromethyl)anilino]nicotinoyl] glycerol and 1,3-dihexadecanoyl-2-[2-[3-(trifluoromethyl)anilino]nicotinoyloxybuta noyl] glycerol also showed a marked anti-inflammatory activity at low concentrations.
Multi-Layered Substrates for Wireless Communication Modules at 60GHz (1999)

A low-cost module structure for millimeterwave wireless communication is proposed. Hermetically sealed circuits and printed antennas are built on the opposite sides of a multi-layered substrate. Slot-coupled electromagnetic interconnects in multi-layered substrates with more than three layers were investigated experimentally. Broad band 50Ο matching and about 4.6dBi gain were achieved by a single patch antenna directly printed on the ceramic multilayered substrate with high εr = 8.9. Suitability of the proposed structure for array antenna design is discussed.
Self-Aligned Charge Read-Out for InAs Nanowire Quantum Dots (2008)

A highly sensitive charge detector is realized for a quantum dot in an InAs nanowire. We have developed a self-aligned etching process to fabricate in a single step a quantum point contact in a two-dimensional electron gas and a quantum dot in an InAs nanowire. The quantum dot is strongly coupled to the underlying point contact that is used as a charge detector. The addition of one electron to the quantum dot leads to a change of the conductance of the charge detector by typically 20%. The charge sensitivity of the detector is used to measure Coulomb diamonds as well as charging events outside the dot. Charge stability diagrams measured by transport through the quantum dot and charge detection merge perfectly.
Two forms of long-term potentiation in area CA1 activate different signal transduction cascades (1996)

1. The effects of protein kinase inhibitors on N-methyl-D-aspartate (NMDA)-receptor-mediated, voltage-dependent calcium channel (VDCC)-mediated, and 100-Hz long-term potentiation (LTP) were studied in area CA1 of rat hippocampal slices. 2. A 25-Hz tetanus induced a quickly developing potentiation that was blocked by the NMDA antagonist D,L-2-amino-5-phosphonovaleric acid (APV) and was not affected by the L-type VDCC inhibitor nifedipine, suggesting that it was mediated by NMDA receptors (NMDA-LTP). 3. Application of a 200-Hz tetanus in APV induced a slowly developing NMDA-receptor-independent potentiation that was blocked by nifedipine and thus named VDCC-LTP. NMDA- and VDCC-LTP reached comparable magnitudes despite their different induction parameters and developmental kinetics. 4. Bath perfusion of the broad-spectrum serine/threonine kinase inhibitor 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine (H-7) blocked NMDA-LTP but not VDCC-LTP, whereas the tyrosine kinase inhibitors genistein and lavendustin A blocked VDCC-LTP but not NMDA-LTP. These results suggest a differential involvement of H-7-sensitive serine/threonine kinases and tyrosine kinases in the two forms of LTP. 5. Tetanization of 200 Hz in control media resulted in a compound potentiation twice as large as NMDA- or VDCC-LTP, implying that the two forms of LTP did not facilitate or reduce each other's expression. The often-used 100-Hz tetanus (1 s twice) induced a potentiation that was comparable in size with the 200-Hz compound LTP. Nifedipine, genistein, and lavendustin A reduced the 100-Hz LTP by approximately 50%, suggesting that this LTP is also a compound potentiation consisting of NMDA- and VDCC-mediated components and their corresponding signal transduction pathways.
Hostile Control of Ships via False GPS Signals: Demonstration and Detection (2017)

An attacker's ability to control a maritime surface vessel by broadcasting counterfeit civil Global Positioning System (GPS) signals is analyzed and demonstrated. The aim of this work is to explore civil maritime transportation's vulnerability to deceptive GPS signals and to develop a detection technique that is compatible with sensors commonly available on modern ships. It is shown that despite access to a variety of high-quality navigation and surveillance sensors, modern maritime navigation depends crucially on satellite navigation and that a deception attack can be disguised as the effects of slowly-changing ocean currents. An innovations-based detection framework that optimally chooses the measurement sampling interval to minimize the probability of a ship exceeding its alert limits without detection is developed and analyzed. A field experiment confirms the vulnerability analysis by demonstrating hostile control of a 65-m yacht in the Mediterranean Sea. Copyright © 2017 Institute of Navigation
Methods and equations for estimating aboveground volume, biomass, and carbon for trees in the U.S. forest inventory, 2010 (2011)

The U.S. Forest Service, Forest Inventory and Analysis (FIA) program uses numerous models and associated coefficients to estimate aboveground volume, biomass, and carbon for live and standing dead trees for most tree species in forests of the United States. The tree attribute models are coupled with FIA's national inventory of sampled trees to produce estimates of tree growing-stock volume, biomass, and carbon, which are available in the Forest Inventory and Analysis database (FIADB; http://fi atools.fs.fed.us). To address an increasing need for accurate and easy-to-use documentation of relevant tree attribute models, needed individual tree gross volume, sound volume, biomass (including components), and carbon models for species in the United States are compiled and described in this publication with accompanying electronic fi les on a CD-ROM included with the publication. This report describes models currently in use as of 2010. These models are subject to change as the FIADB and associated tree attribute models are improved.
American Experience with Alumina Ceramic-Ceramic Bearings in Total Hip Arthroplasty (2003)

Total hip arthroplasty (THA) is an effective surgical procedure for relief of pain and the restoration of diseased hip function. The most common method of THA in the United States currently consists of an uncemented titanium shell, an ultrahigh molecular weight polyethylene (UHMWPE) liner, a modular cobalt-chrome femoral head, and either a cemented or non-cemented femoral component.KeywordsFemoral HeadWear DebrisAcetabular ComponentUltra High Molecular Weight PolyethyleneCeramic LinerThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
N-Acetyl--glucosamine-specific lectin purified from Vibrio cholerae 01 (1992)

An N-acetyl-D-glucosamine-specific cell associated hemagglutinin (HA) was isolated and purified from a strain of Vibrio cholerae 01 by chitin affinity chromatography followed by separation on Bio Gel P-150. A single stained protein band of 47 kDa in sodium dodecyl sulfate-polyacryl-amide gel electrophoresis (SDS-PAGE) was observed with the purified HA. HA-antisera produced a single precipitin band against the purified HA in an immunodiffusion test without exhibiting any reactivity towards purified lipopolysaccharide (LPS). Purified HA, used as solid-phase antigen in an enzyme-linked immunosorbent assay (ELISA), reacted strongly with HA-antisera but cross-reacted negligibly with antisera raised against purified LPS. Hemagglutinating activity of the purified HA was highly sensitive to N-acetyl-D-glucosamine. The immunogold-labelling method using HA-antisera confirmed the location of the HA on the surface of the bacterial cells. The HA-antisera reacted with
Seismic time-invariant convolutional model (1985)

Abstract A layered-earth seismic model is subdivided into two subsystems. The upper subsystem can have any sequence of reflection coefficients but the lower subsystem has a sequence of reflection coefficients which are small in magnitude and have the characteristics of random white noise. It is shown that if an arbitrary wavelet is the input to the lower lithologic section, the same wavelet convolved with the white sequence of reflection coefficients will be the reflected output. That is, a white sedimentary system passes a wavelet in reflection as a linear time-invariant filter with impulse response given by the reflection coefficients. Thus, the small white lithologic section acts as an ideal reflecting window, producing perfect primary reflections with no multiple reflections and no transmission losses. The upper subsystem produces a minimum-delay multiple-reflection waveform. The seismic wavelet is the convolution of the source wavelet, the absorption effect, this multiple-reflection waveform, and the instrument effect. Therefore, the seismic trace within the time gate corresponding to the lower subsystem is given by the convolution of the seismic wavelet with the white reflection coefficients of the lower subsystem. The linear time-invariant seismic model used in predictive deconvolution has been derived. Furthermore, it is shown that any layered subsystem which has small reflection coefficients acts as a linear time-invariant filter. This explains why time-invariant deconvolution filters can be used within various time gates on a seismic trace which at first appearance might look like a continually time-varying phenomenon.
Parkin Protects against Neurotoxicity in the 6-Hydroxydopamine Rat Model for Parkinson's Disease (2006)

Loss-of-function mutations in the PARK2 gene are the major cause of early onset familial Parkinson's disease. The gene product, parkin, is an E3 ligase of the ubiquitin-proteasome pathway involved in protein degradation. Dopaminergic neuron loss may result from the toxic accumulation of parkin substrates, suggesting a key role for parkin in dopaminergic neuron survival. In this study, we have investigated the neuroprotective capacity of parkin in the 6-OHDA rat model for Parkinson's disease. 6-OHDA induces the generation of reactive oxygen species leading to the degeneration of catecholaminergic neurons, but may also impair proteasome activity. Lentiviral vectors encoding human wild-type parkin or green fluorescent protein were stereotactically injected into the substantia nigra 2 weeks prior to a striatal 6-OHDA lesion. Histological analysis 1 and 3 weeks after lesioning showed a significant preservation of dopaminergic cell bodies and nerve terminals. Moreover, lesioned rats overexpressing parkin displayed a corresponding behavioral improvement as measured by the amphetamine-induced rotation test and the cylinder test. The improved performance in the amphetamine-induced rotation test lasted until 20 weeks after lesioning. Our results demonstrate that parkin acts as a potent neuroprotective agent in vivo against 6-OHDA toxic insults. These data support the therapeutic potential of parkin for the treatment of not only familial but also sporadic Parkinson's disease.
Asymmetric Intramolecular [2 + 2] Photocycloadditions:  α- and β-Hydroxy Acids as Chiral Tether Groups (2002)

Chiral alpha- and beta-hydroxy acids such as (S)-lactic acid, (S)-phenyllactic acid, (S)-mandelic acid, or (3R)-3-hydroxybutyric acid have been used as tether groups for intramolecular and diastereoselective [2 + 2] photocycloaddition of 3-oxocyclohexene carboxylic acid derivatives. Total regiocontrol toward the straight adduct and high diastereoselectivities (up to 94%) were observed in the case of butenyl lactate 11. After separation of the two diastereoisomers, cleavage of the chiral tether under basic conditions afforded cyclobutane lactones in good yield and enantiomeric pure form. An X-ray structure has been recorded that confirmed the relative and absolute configuration of the three contiguous stereogenic centers assigned according to CD spectra.
Recent Advancements in User Effect Mitigation for Mobile Terminal Antennas: A Review (2018)

A dramatic evolution can be observed in cellular wireless communication. It started from analog 2G (global system for mobile communication) toward high-data-rate systems such as 3G (wideband code-division multiplexing access), 3.5G (high-speed packet access), 4G (long-term evolution (LTE) and LTE advanced), and currently converging in a more optimized and compact 5G (orthogonal frequency-division multiple access) form. The main challenges for designing of mobile terminal antennas are the compact size requirement of the built-in structure, multiband capabilities, and the number of integrated antennas that form a multiple-input multiple-output (MIMO) terminal system. Moreover, they are required to fulfill all performance and safety standards. For mobile antennas, their radiation efficiency may be affected by the interaction of user head/hand, which consequently affects the correlation of MIMO antenna systems. This paper provides an overview of user effect on mobile terminal antennas in the last seven years. An overview of the Cellular Telecommunication and Internet Association specifications for mobile terminal antennas will first be explained. This is followed by a discussion on the user's effects on MIMO parameters, channel capacity on mobile terminal antennas, and millimeter-wave applications prior to the presentation of recent technologies that are aimed at improving the antenna performance. Finally, a perspective and potential future investigations on mobile terminal antennas will be discussed in the conclusion.
Xanthenones: calixarenes-catalyzed syntheses, anticancer activity and QSAR studies (2015)

An efficient method is proposed for obtaining tetrahydrobenzo[a]xanthene-11-ones and tetrahydro-[1,3]-dioxolo[4,5-b]xanthen-9-ones. The method is based on the use of p-sulfonic acid calix[n]arenes as catalysts under solvent-free conditions. The antiproliferative activity of fifty-nine xanthenones against six human cancer cells was studied. The capacity of all compounds to inhibit cancer cell growth was dependent on the histological origin of the cells. QSAR studies indicate that among compounds derived from β-naphthol the most efficient compounds against glioma (U251) and renal (NCI-H460) cancer cells are those having higher hydrogen bonding donor ability.
A flexible processor for a digital adaptive array radar (2002)

The signal processing for an experimental digital adaptive array radar is described. Conversion to baseband quadrature channels is accomplished digitally using a single analog-to-digital (A/D) converter per channel, and finite impulse response (FIR) equalizing filters are employed in each channel to match channel transfer functions. A modular processor architecture is presented which not only distributes the total processing load, but also the input/output (I/O) bandwidth requirement. This is accomplished by distributing the adaptive beamforming algorithm systolically across a linear array of processing nodes. Experimental data demonstrate that the processor is capable of supporting channel-to-channel cancellation of interfering signals to the level of -65 dB.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Effector Function of Human Tumor-Specific CD8 T Cells in Melanoma Lesions: A State of Local Functional Tolerance (2004)

Although tumor-specific CD8 T-cell responses often develop in cancer patients, they rarely result in tumor eradication. We aimed at studying directly the functional efficacy of tumor-specific CD8 T cells at the site of immune attack. Tumor lesions in lymphoid and nonlymphoid tissues (metastatic lymph nodes and soft tissue/visceral metastases, respectively) were collected from stage III/IV melanoma patients and investigated for the presence and function of CD8 T cells specific for the tumor differentiation antigen Melan-A/MART-1. Comparative analysis was conducted with peripheral blood T cells. We provide evidence that in vivo-priming selects, within the available naive Melan-A/MART-1-specific CD8 T-cell repertoire, cells with high T-cell receptor avidity that can efficiently kill melanoma cells in vitro. In vivo, primed Melan-A/MART-1-specific CD8 T cells accumulate at high frequency in both lymphoid and nonlymphoid tumor lesions. Unexpectedly, however, whereas primed Melan-A/MART-1-specific CD8 T cells that circulate in the blood display robust inflammatory and cytotoxic functions, those that reside in tumor lesions (particularly in metastatic lymph nodes) are functionally tolerant. We show that both the lymph node and the tumor environments blunt T-cell effector functions and offer a rationale for the failure of tumor-specific responses to effectively counter tumor progression.
Identification, Estimation and Testing of Conditionally Heteroskedastic Factor Models.Versión Revisada (1997)

We investigate several important inference issues for factor models with dynamic heteroskedasticity in the common factors. First, we show that such models are identifed if we take into account the time-variation in the variances of the factors. Our results also apply to dynamic versions of the APT, dynamic factor models, and vector auto regressions. Secondly, we propose a consistent two-step estimation procedure which does not rely on knowledge of any factor estimates, and explain how to compute correct standard errors. Thirdly, we develop a simple preliminary LM test for the presence of ARCH effects in the common factors. Finally, we conduct a Monte Carlo analysis of the finite sample properties of the proposed estimators and hypothesis tests.