gebhart/patrepeval huggingface dataset:
Monoterpenes inhibit cell growth, cell cycle progression, and cyclin D1 gene expression in human breast cancer cell lines (1998)

Monoterpenes are found in the essential oils of many commonly consumed fruits and vegetables. These compounds have been shown to exert chemopreventive and chemotherapeutic activities in mammary tumor models and represent a new class of breast cancer therapeutic agents. In this study, we investigated the effects of limonene and limonene-related monoterpenes, perillyl alcohol and perillic acid, on cell growth, cell cycle progression, and expression of cyclin D1 cell cycle-regulatory gene in T-47D, MCF-7, and MDA-MB-231 breast cancer cell lines. Our results revealed that limonene-related monoterpenes caused a dose-dependent inhibition of cell proliferation. Of the three monoterpenes tested, perillyl alcohol was the most potent and limonene was the least potent inhibitor of cell growth. The enantiomeric composition of limonene and perillyl alcohol did not interfere with their effect on cell growth. Sensitivity of breast cancer cell lines to monoterpenes was in the following order: T-47D > MCF-7 > MDA-MB-231. Growth inhibition induced by perillyl alcohol and perillic acid was associated with a fall in the proportion of cells in the S phase and an accumulation of cells in the G1 phase of the cell cycle. Finally, we showed that the effects of limonene-related monoterpenes on cell proliferation and cell cycle progression were preceded by a decrease in cyclin D1 mRNA levels.
Bio-medical entity extraction using Support Vector Machines (2003)

Support Vector Machines have achieved state of the art performance in several classification tasks. In this article we apply them to the identification and semantic annotation of scientific and technical terminology in the domain of molecular biology. This illustrates the extensibility of the traditional named entity task to special domains with extensive terminologies such as those in medicine and related disciplines. We illustrate SVM's capabilities using a sample of 100 journal abstracts texts taken from the {human, blood cell, transcription factor} domain of MEDLINE. Approximately 3400 terms are annotated and the model performs at about 74% F-score on cross-validation tests. A detailed analysis based on empirical evidence shows the contribution of various feature sets to performance.
Native JSON datatype support (2020)

Both RDBMS and NoSQL database vendors have added varying degrees of support for storing and processing JSON data. Some vendors store JSON directly as text while others add new JSON type systems backed by binary encoding formats. The latter option is increasingly popular as it enables richer type systems and efficient query processing. In this paper, we present our new native JSON datatype and how it is fully integrated with the Oracle Database ecosystem to transform Oracle Database into a mature platform for serving both SQL and NoSQL style access paradigms. We show how our uniquely designed Oracle Binary JSON format (OSON) is able to speed up both OLAP and OLTP workloads over JSON documents.
An anti-snapback circuit technique for inhibiting parasitic bipolar conduction during EOS/ESD events (2003)

In this work, an anti-snapback circuit technique called source injection (SI) is presented for the first time, which is shown to inhibit parasitic bipolar conduction during EOS/ESD events. The design is presented for a fully salicided, 0.25 /spl mu/m, 35 /spl Aring//70 /spl Aring/ dual gate oxide, thin-epi, retrograde n-well, bulk CMOS technology. The technique is shown to greatly extend the snapback voltage of NMOS devices in this technology, which are usually destroyed instantaneously once snapback occurs. The design also has the benefit of controlling output buffer impedances for impedance matching to transmission-line loads. The design is fully compatible with the baseline process and has been shown to increase ESD robustness for positive discharge stress modes, which are the most difficult to protect for in epi processes. An increase of >1.5 kV is demonstrated for HBM, an increase of 550 V is shown for MM, and an increase of >550 V is exhibited for CDM, over nonSI and SI I/O pad designs, respectively.
Review of Hydrometallurgical Processes for Recovering Lead from Scrap Lead-acid Batteries (2006)

Lead-acid battery is the main dary material, from which lead could be recovered. Different lead forms including Pb, PbO, PbO2, PbSO4 are involved in the scrap lead-acid batteries. Therefore, recycling scrap lead-acid batteries is relatively complicated. At present, pyrometallurgical and hydrometallurgical technologies are widely used for recyciny lead. Compared with pyrometallurgical technology, hydrometallurgical technology has the advantages of low energy consumption and good environmental benefits. In this paper, friendly-to-environment hydrometallurgical processes for recovering lead from scrap lead-acid batteries are reviewed. Principles and flows of different hydrometallurgical processes are introduced.
Logik (1973)

Wir benötigen die üblichen Bezeichnungen der elementaren Logik: die Quantoren ‘∀x’, ‘∃x’, ‘∀y’, ‘∃y’, usw., die zugehörigen Variablen ‘x’, ‘y’ usw. und die Zeichen ‘¬’, ‘∧’, ‘∨’, ‘→’ und ‘↔’für aussagenlogische Verknüpfungen. Dieses Vokabular der elementaren Logik stellt das allgemeine Werkzeug dar, mit dessen Hilfe man aus atomaren Aussagen innerhalb einer speziellen Theorie, in der es um Objekte einer speziellen Art geht, zusammengesetzte Aussagen bilden kann. Die spezielle Theorie — welche es auch immer sein mag — liefert dann ihre eigenen besonderen Prädikate, die man zum Aufbau der atomaren Aussagen braucht, von denen jede aus einem solchen Prädikat und einer oder mehreren Variablen besteht, die die Rolle der zum Prädikat gehörenden Subjekte spielen.
Early Skill Learning Is Expressed through Selection and Tuning of Cortically Represented Muscle Synergies (2003)

Skill learning may be based on integrating and adapting movement building blocks organized in the CNS. We examined at what level integration and adaptation occur during early skill learning, the level of individual muscles, muscle synergies or combinations of synergies through time, and whether these operations are expressed through the primary motor cortex (M1). Forelimb muscle and M1 cell activity were recorded over the first day of training on a reach-to-grasp task in rodents. Independent components analysis was used to assess how well muscle activation patterns could be described as time-varying combinations of synergies. In 3 of 11 animals, prereach M1 activity predicted the activation of different combinations of independent components (ICs) to perform the task. With training, animals increasingly adopted postures and prereach patterns of M1 activity that supported activation of the more successful combination. With training, animals also adjusted the activation magnitude (6 of 11 animals) and weights (11 of 11) of specific ICs that constituted the selected combination. Weights represent how IC activation patterns were distributed to forelimb muscles; this distribution pattern was adapted with training. M1 cells (37 of 100) had task-related firing rates that were significantly correlated with IC activation patterns. Changes in M1 firing rates were associated with corresponding changes in either the activation magnitude or weights of the correlated IC. Our data suggest that early skill learning is expressed through selection and tuning of M1 firing rates, which specify time-varying patterns of synergistic muscle contractions in the limb.
Elastic image matching with embedded rigid structures using spring-mass system (2004)

The paper presents a novel elastic image-matching algorithm, which is capable of treating some preselected parts of an image as rigid objects, while remainder of the image can be elastically deformed. The proposed method uses a spring-mass system to model deformations caused by displacement of the rigid objects and/or preselected feature landmarks. The proposed method gives more control over deformations comparing to the methods using purely interpolation of sparse points techniques (e.g. radial basis function), but is not as computationally demanding or difficult to used as the methods based on an accurate physical modeling of the deformable structures. The performance of the proposed elastic warping of the image with the embedded rigid structures is shown using simulated data, and is validated using a pair of real computed tomography (CT) images. The objective measures as well as images enabling subjective evaluation of the new technique are provided.
New versatile ketone spin label (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew versatile ketone spin labelJohn F. W. Keana, Sue B. Keana, and Dennis. BeethamCite this: J. Am. Chem. Soc. 1967, 89, 12, 3055–3056Publication Date (Print):June 1, 1967Publication History Published online1 May 2002Published inissue 1 June 1967https://pubs.acs.org/doi/10.1021/ja00988a049https://doi.org/10.1021/ja00988a049research-articleACS PublicationsRequest reuse permissionsArticle Views328Altmetric-Citations217LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The spatial and temporal pattern of collagens I and II and keratan sulphate in the developing chick metatarsophalangeal joint (1987)

Both intrinsic and extrinsic factors are known to be involved in the morphogenesis of diarthrodial joints. The use of specific antibodies to collagens I and II and keratan-sulphate-containing proteoglycans (KSPG) has enabled the distributions of these macromolecules to be followed during the development of the third metatarsophalangeal joint in the chicken embryo. Our study shows that cartilage differentiation occurs as a continuous rod, which is then subsequently divided into separate elements. Further development also reveals that, unlike the matrix of the cartilaginous elements, there is a differential distribution of collagen (type II) and KSPG in the presumptive joint region. It is proposed that a decrease in KSPG in the presumptive joint region at stages 28/30 may be involved in the mechanism for the flattening of cells in formation of the interzone. Whereas, a decrease in collagen across the joint interzone region may provide an area of weakness, which might allow forces produced by the developing musculature to cause cavitation.
Mechanical Properties of &alpha;+&kappa; Two-phase Lamellar Structure in Fe-Mn-Al-C Alloy (2003)

E21-Fe3AlC carbide (κ) in the Fe–Al–C ternary system is known to have ductility at room temperature. It forms a lamellar structure similar to the pearlite with a ferrite (α) phase through a eutectoid-like reaction from an austenite (γ) phase and improved mechanical properties are expected by replacing cementite to κ phase. The mechanical properties of α+κ two-phase lamellar structure were investigated through micro-Vickers hardness measurements and compression tests at room temperature in order to compare with those of pearlite steels. A typical mean inter-lamellar spacing of Fe–8 at%Mn–13 at%Al–7 at%C alloy aged at 773 K for 100 h was 60 nm and its yield stress and micro-Vickers hardness were 1880 MPa and 580 HV, respectively. Yield stress and micro-Vickers hardness of these specimens were higher than those of pearlite steels regardless of the mean inter-lamellar spacing. Those results seem to be rationalized by taking the solid solution hardening of ferrite phase into account.
The Deciduous Dentition of the Central American Phyllostomid Bats Macrotus waterhousii and Pteronotus suapurensis (1966)

Craig E. Nelson, The Deciduous Dentition of the Central American Phyllostomid Bats Macrotus waterhousii and Pteronotus suapurensis, The Southwestern Naturalist, Vol. 11, No. 1 (Mar. 30, 1966), pp. 142-143
Gas Chromatography of Cigarette Smoke, Part III. Separation of the Overlap Region of Gas and Particulate Phase by Capillary Columns (1965)

Following the investigation of gas phase constituents boiling within the range of 20–100°C, as presented in Part II, the section of less volatile substances with boiling points between 100 and 200°C has been studied. The separation by capillary columns is demonstrated, and 64 substances are indicated as probable gas phase constituents. The partition of certain substances between gas phase and particulate phase is shown to be of great importance. Some influences upon the partition equilibrium, for instance charcoal filters, are discussed.
Comparative analysis of portal cell infiltrates in antimitochondrial autoantibody–positive versus antimitochondrial autoantibody–negative primary biliary cirrhosis (2011)

Our data suggest a putative role of B-cell autoimmunity in regulating the portal destruction characteristic of PBC.
Tumor protein 53 mutations are enriched in diffuse large B-cell lymphoma with irregular CD19 marker expression (2017)

Accumulating evidence suggests tumor protein 53 (p53) promotes correct cellular differentiation. Thus, mutant TP53 may be more frequent in tumors with irregular differentiation. This study investigated whether TP53 mutations were more frequent in diffuse large B cell lymphoma (DLBCL) that lacked the B cell lineage marker CD19. Sixteen CD19 negative and 78 CD19 positive DLBCL were sequenced for TP53 mutations. Twenty nine tumors had TP53 mutations and were associated with poorer survival. Mutant TP53 was more frequent in CD19 negative lymphomas (81% versus 21%, p < 0.0001). Analysis of other B cell markers revealed a lack of paired box 5 (PAX5) in CD19 positive lymphomas with mutant TP53 (50%), which was more frequent compared to tumors with wild-type TP53 (15%, p = 0.002). In summary, DLBCL lacking CD19 or PAX5 expression were more likely to have mutant TP53, suggesting irregular B cell marker phenotypes are associated with TP53 mutation.
Random Telegraph Signal Noise in CMOS Image Sensor (CIS) and Use of a CIS in a Low-Cost Digital Microscope (2011)

The introduction of the digital image sensor has triggered a revolution in the field of imaging. It has not only just replaced the conventional silver halide film based imaging system, but has also enormously widened the scope of imaging applications. Previously, charge-coupled devices (CCDs) were the most popular technology for image sensors. But in the past decade, they have been rapidly replaced by the CMOS image sensor (CIS) technology. The CCD image sensors offers higher sensitivity, wider dynamic range and better resolution compared to its CMOS imager counterparts. However, the lower power performance, higher speed of operation, easier integration with signal control and processing circuitries, and the use well-established mainstream fabrication process of CMOS technology, are key advantages that have served to propel CMOS imagers beyond CCDs in the market. However, CIS suffers from higher temporal noise compared to that of CCDs. One of the major noise sources in CIS is the 1/ noise generated from the in-pixel active amplifier. Due to continuous shrinking of MOS devices, the random telegraph signal (RTS) noise is emerging as a dominant noise source over other low frequency noise in CMOS imagers, resulting into reduced imaging performance. The RTS noise which evolves from trapping and de-trapping of electrons by the defects in the oxide, causes fluctuation in the drain current of the MOSFET. In this work, we have carried out time-domain measurement of RTS noise in CIS pixels. The time domain RTS measurements provide useful information about its characteristics in different operating conditions, which can be further used to extract the trap parameters and determine the optimum settings of operation of CIS. The capability of integrating various on-chip operations, higher speed and lower fabrication cost has made the CIS a good choice for various imaging applications. In order to demonstrate the extent of possible applications of CIS, we have developed an imaging system using a CIS. Two major concerns of biomedical imaging systems are their speed and cost. The system presented here is implemented using a CIS and FPGA (field programmable gate array) that provides a low-cost and high frame rate solution for biomedical microscopy.
Titration without Mixing or Dilution:  Sequential Injection of Chemical Sensing Membranes (1997)

A novel, miniaturized titration was developed using beads 35 μm in diameter as semisolid aqueous titrant retained in a nonaqueous sample stream. Agarose beads with internally bound pH indicator served as a pH sensing membrane material swollen with aqueous NaOH titrant. The indicator monitored the remaining titrant within the agarose beads during perfusion with H(2)SO(4) in 1-butanol samples. Irreversible reaction of 2 mg bead layers was made possible by automated packing and disposal in a flow cell. This strategy substituted membrane advantages for the burdens of mixing and unnecessary dilution under laminar flow conditions. The agarose environment was conditioned with NaCl to tolerate dissolved salt in the sample. Transmittance measurements were made via fiber optics through FEP PTFE optical windows. A simple inverse relationship held between endpoint volume and acid concentration so that calibration curves were linear, R(2) = 0.9980.
A fully-synchronous offset-insensitive level-crossing analog-to-digital converter (2016)

A fully-synchronous offset-insensitive structure is proposed for implementing level-crossing analog-to-digital converters (LC-ADCs). The proposed structure is designed and implemented for high-precision compressed electrocardiogram (ECG) monitoring applications. Synchronous implementation leads to less implementation complexity compared to the conventional asynchronous implementations. Also the major source of error, viz. the difference in comparators offsets is eliminated which additionally leads to considerable saving in silicon area. Designing and simulating in a 0.18 μm CMOS technology, the LC-ADC achieves an ENOB of 8.45 bits and occupies 0.038 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> silicon area. The average sampling rate is about 120 S/s when applied to the whole MIT/BIH arrhythmia database. Simulation results show a power consumption of 81 nW with a 1.8 V supply voltage, by testing the ADC using Tape 100 of the MIT/BIH arrhythmia database.
Nonenzymatic Glycosylation and Browning in Diabetes and Aging: Studies on Lens Proteins (1982)

The nonenzymatic glycosylation of hemoglobin has served as a model for the postsynthetic modification of protein by glucose. From these studies it has been proposed that nonenzymatic glycosylation of proteins could play a role in the development of the complications associated with diabetes mellitus. The first tissue in which an attempt has been made to link nonenzymatic glycosylation and a pathologic sequela is the ocular lens and the formation of cataracts. Incubation of lens proteins with glucose in vitro leads to nonenzymatic glycosylation, intermolecular disulfide bond formation, and protein aggregates that defract light. These findings mimic the state of proteins found in the diabetic lens. With longer incubation times, these nonenzymatically glycosylated proteins can undergo further rearrangements to form yellow-brown pigments (nonenzymatic browning) that act as molecular cross-links. From a number of physical and chemical studies it appears that these pigments formed in vitro are similar to those found in senile lenses. Thus the nonenzymatic browning of glycosylated proteins that has been described in stored foodstuffs might well be occurring in vivo. Such protein modifications, which are essentially irreversible, could have significant effects on the aging of long-lived proteins and the general aging process of biologic systems.
Accuracy Limitations of Range-Range (Spherical) Multilateration Systems (1973)

This report presents a novel procedure for determining the accuracy of range-range (or spherical) multilateration systems. The procedure is a generalization of one previously described for hyperbolic multilateration systems. A central result is a demonstration that the inverse of the covariance matrix for positional errors corresponds to the moment of inertia matrix of a simple mass configuration. The insight afforded by this fact is used to resolve a number of questions relating to accuracy.\n
Modeling and simulation of a high accurate aircraft ground-based positioning and landing system (2013)

The rapid increase in aviation industry requires parallel effective plans, programs and designs of systems and facilities nationwide to fulfill the increasing needs for safe air transportation. Aircraft landing remains a problem for a long time all over the world. Systems that aircraft rely on in landing are unreliable to perform a precise guidance due to many limitations such as inaccuracy, unreliability and dependency. In low visibility conditions, aircrafts are diverted to another airport. However, low visibility can also affect all airports in the vicinity, forcing aircrafts to land in low visibility conditions depending on Instrument Flight Rules (IFR). Aircraft approach and landing are the most hazardous portions of flight; accidents records indicated that approximately 50 percent of the accidents occur during these portions. Aircraft landing Category IIIC is not yet in operation anywhere in the world. It requires landing with no visibility or runway visual range. Currently, Global Positioning System (GPS) is the main navigation system used all over the world for aircraft navigation, approach and landing. However, GPS accuracy is not sufficient to perform a perfect landing due to the possibility of aircraft to be drifted out of the runway. The accuracy of GPS could be improved to 3 meter by receiving correction messages. Improved accuracy has not been able to meet International Civil Aviation Organization (ICAO) standards for aircraft precision landing. In this study, aircraft landing systems characteristics, performances and accuracies have been studied and compared for the purpose of assessing limitations and drawbacks. An aircraft landing system with improved performance is proposed to meet ICAO standards for all-weather aircraft landing and to provide accurate guidance for approaching and landing aircrafts.
Using mobile agents as roaming security guards to test and improve security of hosts and networks (2004)

This paper discusses the design and implementation details of MAST (Mobile Agent-based Security Tool), a new mobile agent-based network security approach. MAST has been designed to support flexible and customizable network security tasks and training. This paper focuses on the implementation details and security aspects of MAST's components, services, and mobile-agent architecture