gebhart/patrepeval huggingface dataset:
Effects of different antioxidants on lens-induced uveitis. (1996)

For evaluation of the effects of different free-radical scavengers on biochemical changes in lens-induced uveitis (LIU), ten male Wistar rats were sensitized for 8 weeks using bovine lens protein and Freund's adjuvant. The uveitis was induced by disruption of the lens capsule. One group of animals received superoxide dismutase and catalase (SOD/CAT); a second group of animals was treated with vitamin E. Lipid peroxides (LPO) of the retinal tissue and aqueous humor served as parameter of oxidative tissue damage. Glutathione (GSH/GSSG) of the aqueous humor was evaluated as a parameter of the tissue's redox state. For evaluation of the inflammatory response, myeloperoxidase activity (MPO) was determined in the iris/ciliary-body complex. SOD/CAT produced no improvement in the significantly (P < 0.05) elevated MPO and LPO values recorded for untreated control animals. Following vitamin E treatment the GSH/GSSG and LPO values in aqueous humor were markedly improved as compared with controls. Retinal LPO values were significantly (P < 0.05) reduced as compared with controls. No change in MPO levels was observed. The results demonstrate that enzymes such as SOD and CAT do not influence tissue damage at a significant level, whereas radical chain breakers such as vitamin E can do so. However, the inflammatory response itself is not reduced. To achieve global results, drugs are necessary that act on both free radicals produced by noninflammatory pathways and those originating from inflammation.
Design and characteristics of staggered InGaN quantum-well light-emitting diodes in the green spectral regime (2009)

Staggered InGaN quantum wells (QWs) are investigated both numerically and experimentally as improved active region for light-emitting diodes (LEDs) emitting at 520–525 nm. Based on a self-consistent six-band k·p method, band structures of both two-layer staggered InxGa1−xN/InyGa1−yN QW and three-layer staggered InyGa1−yN/InxGa1−xN/InyGa1−yN QW structures are investigated as active region to enhance the spontaneous emission radiative recombination rate (Rsp) for LEDs emitting at 520–525 nm. Numerical analysis shows significant enhancement of Rsp for both two-layer and three-layer staggered InGaN QWs as compared to that of the conventional InzGa1−zN QW. Significant reduction of the radiative carrier lifetime contributes to the enhancement of the radiative efficiency for both two-layer and three-layer staggered InGaN QW LEDs emitting at 520–525 nm. Three-layer staggered InGaN QW LEDs emitting at 520–525 nm was grown by metal-organic chemical vapour deposition (MOCVD) by employing graded-temperature profile. Power density-dependent cathodoluminescence (CL) measurements show the enhancement of peak luminescence by up to 3 times and integrated luminescence by 1.8–2.8 times for the three-layer staggered InGaN QW LED. Electroluminescence (EL) output power of the staggered InGaN QW LED exhibits 2.0–3.5 times enhancement as compared to that of the conventional InGaN QW LED. The experimental results show the good agreement with theory.
Attached Bacterial Populations Shared by Four Species of Aquatic Angiosperms (2008)

Symbiotic relationships between microbes and plants are common and well studied in terrestrial ecosystems, but little is known about such relationships in aquatic environments. We compared the phylogenetic diversities of leaf- and root-attached bacteria from four species of aquatic angiosperms using denaturing gradient gel electrophoresis (DGGE) and DNA sequencing of PCR-amplified 16S rRNA genes. Plants were collected from three beds in Chesapeake Bay at sites characterized as freshwater (Vallisneria americana), brackish (Potomogeton perfoliatus and Stuckenia pectinata), and marine (Zostera marina). DGGE analyses showed that bacterial communities were very similar for replicate samples of leaves from canopy-forming plants S. pectinata and P. perfoliatus and less similar for replicate samples of leaves from meadow-forming plants Z. marina and V. americana and of roots of all species. In contrast, bacterial communities differed greatly among plant species and between leaves and roots. DNA sequencing identified 154 bacterial phylotypes, most of which were restricted to single plant species. However, 12 phylotypes were found on more than one plant species, and several of these phylotypes were abundant in clone libraries and represented the darkest bands in DGGE banding patterns. Root-attached phylotypes included relatives of sulfur-oxidizing Gammaproteobacteria and sulfate-reducing Deltaproteobacteria. Leaf-attached phylotypes included relatives of polymer-degrading Bacteroidetes and phototrophic Alphaproteobacteria. Also, leaves and roots of three plant species hosted relatives of methylotrophic Betaproteobacteria belonging to the family Methylophilaceae. These results suggest that aquatic angiosperms host specialized communities of bacteria on their surfaces, including several broadly distributed and potentially mutualistic bacterial populations.
Net Reclassification Improvement: Computation, Interpretation, and Controversies (2014)

The net reclassification improvement (NRI) is an increasingly popular measure for evaluating improvements in risk predictions. This article details a review of 67 publications in high-impact general clinical journals that considered the NRI. Incomplete reporting of NRI methods, incorrect calculation, and common misinterpretations were found. To aid improved applications of the NRI, the article elaborates on several aspects of the computation and interpretation in various settings. Limitations and controversies are discussed, including the effect of miscalibration of prediction models, the use of the continuous NRI and “clinical NRI,” and the relation with decision analytic measures. A systematic approach toward presenting NRI analysis is proposed: Detail and motivate the methods used for computation of the NRI, use clinically meaningful risk cutoffs for the category-based NRI, report both NRI components, address issues of calibration, and do not interpret the overall NRI as a percentage of the study population reclassified. Promising NRI findings need to be followed with decision analytic or formal cost-effectiveness evaluations.
Rapid SAR measurement of mobile phones (2004)

Specific Absorption Rate (SAR) designates the electromagnetic power density deposited per unit mass of biological tissues. This paper presents a new approach where SAR calculation for mobile phones is based on a parametric reconstruction of the E-field distribution in the phantom to assess rapid SAR measurements, by means of an ellipsoidal model. The estimation of its parameters is achieved by two ways: using a reduced number of real data points exclusively, and using a combination of real data points and E-field extrapolation with a given expansion model.
Benign prostatic hyperplasia: challenges for the new millennium (2000)

The understanding and therapy of benign prostatic hyperplasia (BPH) has become more complex recently. The molecular mechanisms and growth factors involved in BPH need to be elucidated in the new millennium. The current classification of disease reflects the varied pathophysiologic mechanisms causing lower urinary tract symptoms (LUTS). In addition, symptom scores have improved evaluation of men with BPH, yet 'bother' and 'health-related quality of life' should be better recognized as significant outcome parameters. Clinical evaluation with laboratory markers specific for BPH or LUTS is currently inadequate. Yet, urodynamic evaluation should remain an important aspect of evaluation to guide selection of therapy. Recently medical therapy has expanded to include uroselective alpha blockade and phytotherapy, yet more research is needed. The most significant growth in the field, however, is in minimally invasive therapies of the prostate. Long-term comparative prospective multicenter studies are needed to properly evaluate the outcomes of new technologies compared to traditional procedures that are considered standard of care.
Disorders of Neuromuscular Transmission Caused by Drugs (1979)

MORE than 30 drugs in current clinical use, other than those used in anesthesia, may interfere with neuromuscular transmission. This complication of drug therapy is unusual but has been well documented; over 200 cases have been reported.1 Awareness of the possibility of such an effect is important, since failure to recognize that a drug is responsible for, or is contributing to, a myasthenic syndrome may lead to unnecessary morbidity and even to a fatal outcome in what is potentially a reversible condition. Although clinically manifest neuromuscular blockade is uncommon, subclinical involvement is probably more frequent than is generally appreciated.Clinical . . .
A model for acoustic vaporization of encapsulated droplets (2015)

The use of encapsulated liquid nanoparticles is currently largely investigated for medical applications, mainly because their reduced size allows them to enter targeted areas which cannot be reached by large microbubbles (contrast agents). Low-boiling point perfluorocarbon droplets can be vaporized on-site under the action of the ultrasonic field, in order to turn them into echogeneous-eventually cavitating-microbubbles. This paper presents a theoretical model describing this phenomenon, paying particular attention to the finite size of the droplet and its encapsulation by a thin viscoelastic layer. Numerical simulations are done for droplets of radii 1 and 10 μm and for frequencies of 1-5 MHz. Results reveal that droplet surface tension and shell rigidity are responsible for an increase of the acoustic droplet vaporization threshold. Furthermore, this threshold does not vary monotonically with frequency, and an optimal frequency can be found to minimize it. Finally, the role of some physical properties on the dynamics of the particle is analyzed, such as the contrast of inner and outer liquids densities and the mechanical properties of the shell.
Symmetric primal-dual approximate linear programming for factored MDPs (2006)

A weakness of classical Markov decision processes is that they scale very poorly due to the flat state-space representation. Factored MDPs address this representational problem by exploiting problem structure to specify the transition and reward functions of an MDP in a compact manner. However, in general, solutions to factored MDPs do not retain the structure and compactness of the problem representation, forcing approximate solutions, with approximate linear programming (ALP) emerging as a very promising MDP-approximation technique. To date, most ALP work has focused on the primal-LP formulation, while the dual LP, which forms the basis for solving constrained Markov problems, has received much less attention. We show that a straightforward linear approximation of the dual optimization variables is problematic, because some of the required computations cannot be carried out efficiently. Nonetheless, we develop a composite approach that symmetrically approximates the primal and dual optimization variables (effectively approximating both the objective function and the feasible region of the LP) that is computationally feasible and suitable for solving constrained MDPs. We empirically show that this new ALP formulation also performs well on unconstrained problems. 1.
Large-Scale Deep Learning For Building Intelligent Computer Systems (2016)

For the past five years, the Google Brain team has focused on conducting research in difficult problems in artificial intelligence, on building large-scale computer systems for machine learning research, and, in collaboration with many teams at Google, on applying our research and systems to dozens of Google products. Our group has recently open-sourced the TensorFlow system (tensorflow.org), a system designed to easily express machine ideas, and to quickly train, evaluate and deploy machine learning systems. In this talk, I'll highlight some of the design decisions we made in building TensorFlow, discuss research results produced within our group, and describe ways in which these ideas have been applied to a variety of problems in Google's products, usually in close collaboration with other teams.
Functionalization of Polyhedral Oligomeric Silsesquioxane (POSS) via Nucleophilic Substitution (2009)

Octakis(3-chloropropyl)octasilsesquioxane, obtained recently by a new method, has enabled a highly efficient synthesis of a whole family of cube-like T8 silsesquioxanes by nucleophilic substitution of chlorine atom with appropriate nucleophilic agents. Five functionalized silsesquioxanes, i.e., octakis[3-(methacryloyl­oxy)propyl]-, octakis(3-acetoxypropyl)-, octakis[3-(phenylamino)propyl]-, and octakis[3-(4-methylpiperazin-1-yl)propyl]octa­-silsesquioxane as well as octakis{3-[(2-hydroxyethyl)dimethyl­ammonio]propyl}octasilsesquioxane chloride were synthesized and characterized by spectroscopic methods and elemental analysis.
Unit Commitment (1966)

The unit commitment program for the GE 412 digital process control computer optimizes the shutdown and startup of generating units so as to achieve minimum system fuel costs. Additional savings in the order of two to fifteen dollars per year per MW of installed capacity are estimated [1] over those gained from a feasible schedule. The program is flexible and considers numerous special operating restrictions. Several problems pertinent to Florida Power Corporation were solved within the program framework. Interrelation with other programs and various output options are discussed.
Effective Link Triggers to Improve Handover Performance (2006)

Effective link layer triggering is the key in order to enable fast and reliable handovers across different access networks. In this paper, we investigate the use of signal strength as part of the trigger mechanism. We propose an analytical model to estimate the anticipation required in order to achieve a target handover packet loss performance, for both voice and video traffic patterns. Numerical results from the analytical model are presented and compared to simulation data obtained for realistic handover scenarios.
Accounting: Information for Decisions (1998)

The accounting information system: accounting and organizations information in organization accounting measurement processing accounting information reporting accounting information financial reporting. (Part contents).
Spontaneous Diabetic BB Rat: Studies of Cyclic Adenosine 3′,5′-Monophosphate Phosphodiesterase and Calmodulin* (1986)

Uncontrolled diabetes in man is associated with increased plasma and tissue levels of cAMP and decreased cAMP phosphodiesterase (PDE) activity. Spontaneously diabetic BB rats (SDR) were used in these experiments. Specific tissues (i.e. liver and epididymal fat) were studied without therapeutic insulin. Another group of normal animals were rendered diabetic by streptozotocin (STZ) and killed without benefit of insulin therapy. Calmodulin (CM), a small molecular weight protein essential for activation of specific cAMP PDE was assayed. STZ diabetes is associated with a decrease (58%) in CM biological activity and in immunoreactive CM in fat (69%) and liver (13%) tissues. Similarly, SDR rats and the nondiabetic genetic controls (NDR) demonstrate decreased CM bioactivity in fat (76% and 56%, respectively) and decreased CM immunoreactivity in liver (68% and 74%, respectively) compared to normal control rats. In addition, maximum velocity (Vmax) of the low Michaelis-Menten constant (Km) cAMP PDE is decreased in SDR animals, as compared to controls in both fat (42%) and liver (39%) tissues. Similar data are presented for NDR animals. STZ diabetes is also associated with a reduction in Vmax of the low Km cAMP PDE in both liver (70%) and fat (70%) tissues. These changes found in the NDR animals suggests that the diabetic defect may be under dual regulation: genetic and environmental.
Fabrication and characterization of MgO-based magnetic tunnel junctions for spin momentum transfer switching (2007)

Current-induced spin-torque switching was demonstrated on sub-100 nm magnetic tunnel junction devices fabricated on 200 mm substrates utilizing 180 nm complimentary metal–oxide–semiconductor back-end-of-the-line (BEOL) technology. Low resistance-area (RA) product and high tunneling magnetoresistance (TMR) were achieved by using substrates containing a CoFeB free layer and a thin MgO barrier. To obtain the desired sub-100 nm features, photoresist trimming was applied on patterns created by a 248 nm lithography tool. Furthermore, the magnetic stack was defined using an ion beam etch that stopped on the thin MgO barrier. Field-sweep measurements on elliptical devices that are 80 nm wide and 160 nm long indicated RA∼4 Ω μm2 and TMR∼90%. Upon injecting current into the devices while applying an external offset field of 28 Oe, current-induced switching occurred from parallel (P) to antiparallel (AP) state at +1.3 mA, and from AP to P state at −1.25 mA. BEOL process integration on 200 mm substrates enabled statistical analysis of device properties, such as the observation of two breakdown mechanisms in the devices.
Dedicated <i>ent</i> -kaurene and <i>ent</i> -atiserene synthases for platensimycin and platencin biosynthesis (2011)

Platensimycin (PTM) and platencin (PTN) are potent and selective inhibitors of bacterial and mammalian fatty acid synthases and have emerged as promising drug leads for both antibacterial and antidiabetic therapies. Comparative analysis of the PTM and PTN biosynthetic machineries in Streptomyces platensis MA7327 and MA7339 revealed that the divergence of PTM and PTN biosynthesis is controlled by dedicated ent-kaurene and ent-atiserene synthases, the latter of which represents a new pathway for diterpenoid biosynthesis. The PTM and PTN biosynthetic machineries provide a rare glimpse at how secondary metabolic pathway evolution increases natural product structural diversity and support the wisdom of applying combinatorial biosynthesis methods for the generation of novel PTM and/or PTN analogues, thereby facilitating drug development efforts based on these privileged natural product scaffolds.
Minimizing leukemia escape: implementing a dual anti-CD20- and CD19-scFv-based chimeric antigen receptor (CAR) (2015)

Meeting abstracts Adoptive immunotherapy with chimeric antigen receptor (CAR) transduced T lymphocytes has shown promising results in both pediatric and adult B cell malignancies. Nevertheless, both CAR-based and antibody-based anti-CD19 therapies, e.g. blinatumomab, have seen treatment failures
Hearing Services Program (2015)

This program helps eligible people with the cost of hearing services, assessments and devices.
<title>Amorphous Te-C Films For An Optical Disk</title> (1982)

A new recording medium for optical disks was investigated. The new medium, called Te-C film, is characterized by a high sensitivity and stability, compared to Te films. This paper presents the optical recording characteristics for Te-C films on PMMA substrates and its stability under stressed conditions. Then, the high sensitivity and stability origins are discussed.
Protein Nanotube Selectively Cleavable with DNA: Supramolecular Polymerization of “DNA-Appended Molecular Chaperones” (2017)

Here, we report molecular chaperone GroELs that carry, at their apical domains, multiple DNA strands (ideally 28 DNA strands in total) with defined oligonucleotide (nt) sequences. This design strategy allows for the preparation of GroEL<sub>10a</sub> and GroEL<sub>10b</sub> carrying 10-nt DNA strands of 10a and 10b with complementary sequences, respectively, at their apical domains. One-dimensional coassembly of these GroELs is possible to form protein nanotube NT<sub>10a/10b</sub> with an anomalous thermodynamic stability due to the exceptionally large multivalency for the coassembly. Likewise, comparably stable nanotube NT<sub>15c/10d</sub> was obtained even when the apical-domain DNA strands (15c and 10d) were partially complementary to one another. Nevertheless, in sharp contrast with NT<sub>10a/10b</sub>, NT<sub>15c/10d</sub>, when incubated with DNA 15d, dissociates rapidly and completely because 15d preferentially hybridizes with the DNA strands of 15c in NT<sub>15c/10d</sub> by displacing those of 10d, to afford a mixture of GroEL<sub>15c/15d</sub> and GroEL<sub>10d</sub>. Even in the presence of NT<sub>10c/10d</sub>, 15d cleaved off NT<sub>15c/10d</sub> selectively, indicating the potential utility of NTs for targeted delivery.
Effect of alkali-metal ion addition to silica-supported molybdenum oxide on photocatalysis Photooxidation of propane and propene, and photo-assisted metathesis of propene (1998)

The effect of adding alkali-metal ions (Li +, Na +, K +, and Rb +) to silica-supported molybdenum oxide (MoO 3/SiO 2) has been investigated by photooxidation of propane and propene with gaseous oxygen, and photo-assisted metathesis of propene at room temperature. Over alkali-metal ion modified MoO 3/SiO 2, propanone has been mainly produced from propane, and acrolein from propene, whereas over MoO 3/SiO 2 a variety of products have been formed, such as ethanal, propene, propanone and propanal from propane, and ethanal and acrolein from propene. The photooxidation selectivities change upon the addition of alkali-metal ions because the electrophilicity of the oxygen atom in the molybdenum species in the excited state ( i. e., it is active for photooxidation) is weakened by the interaction with the alkali-metal ions. In the photo-assisted metathesis reaction of propene, the conversion is lower over alkali-metal ion modified MoO 3/SiO 2 than over MoO 3/SiO 2. The activity for the metathesis reaction has been related to the reducibility of the surface molybdenum species by CO under UV light irradiation. In addition, the Raman spectra suggest that the surface molybdenum species in alkali-metal ion modified MoO 3/SiO 2 is like Mo 2O 72- besides a small amount of MoO 42-, whereas the molybdenum species in MoO 3/SiO 2 exists as a mononuclear species.
Publishing online, a commercial (ad)venture (1995)

Article Free Access Share on Publishing online, a commercial (ad)venture Authors: Nancy Cooke North Carolina State University and C & M Online Media Inc. North Carolina State University and C & M Online Media Inc.View Profile , David McAllister North Carolina State University and C & M Online Media Inc. North Carolina State University and C & M Online Media Inc.View Profile Authors Info & Claims SIGDOC '95: Proceedings of the 13th annual international conference on Systems documentation: emerging from chaos: solutions for the growing complexity of our jobsFebruary 1996 Pages 20–25https://doi.org/10.1145/223984.223989Published:01 February 1996Publication History 0citation321DownloadsMetricsTotal Citations0Total Downloads321Last 12 Months6Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Interleukin-12 Receptor/STAT4 Signaling Is Required for the Development of Autoimmune Myocarditis in Mice by an Interferon-γ–Independent Pathway (2001)

IL-12/IL-12R/STAT4 signaling promotes the development of EAM. In contrast, IFN-gamma plays a protective role. The disease-limiting effects of IFN-gamma might be explained by its ability to control the expansion of activated T lymphocytes.