gebhart/patrepeval huggingface dataset:
Epsilon-Polylysine Microparticle Adjuvant Drives Cytokine Production to Th1 Profile (2007)

Epsilon-polylysine micro particles (SGEPL) and polyethyleneimine micro particles (SGPEI) were developed by the addition of a hydrophobic group and the immunological characterization of these micro particles and aluminum hydroxide (ALUM) was investigated. BALB/c mice were injected intraperitoneally with ovalbumin (OVA) as an antigen and SGEPL, SGPEI or ALUM as an adjuvant. The results showed that the mice injected with SGEPL produced a significant portion of anti-OVA antibody subclass IgG2a in the sera and suppressed interleukin (IL)-4 and IL-5, but enhanced IL-12 and interferon-gamma (IFN-gamma) from the spleen cells. Similar results relating to cytokines were also obtained, even without OVA. Direct stimulation with SGEPL to naïve BALB/c mouse spleen cells induced IL-12 and IFN-gamma. Both spleen and purified B cells produced IgG1 and IgE after stimulation with IL-4 and the anti-CD40 monoclonal antibody. With the addition of SGEPL, the IgE production from the cells was suppressed as a result of enhanced IFN-gamma production. Furthermore, IgE production was also suppressed in the purified B cells without the influence of IFN-gamma or IL-12. Thus, we suggest SGEPL drives cytokine production to Th1 profile. It will be a novel promising adjuvant based on this viewpoint.
High performance sub-half micron CMOS using rapid thermal processing (2002)

A sub-half micron CMOS technology has been developed using rapid thermal processing (RTP) and a simplified process design. The threshold voltages are set high to permit operation above room temperature without excessive leakage. Novel process features include zero-topography well design, RTP CMOS well anneal in an ammonia ambient, RTP gate oxide, RTP source/drain anneal, and BPSG reflow at 750 degrees C in a high-pressure nitrogen ambient. Transistors with 8 nm gate oxide and 0.4 mu m gate lengths provide 65 ps gate delay at 3.3 V. The use of 4*10/sup 17//cm/sup 3/ CMOS well doping without added channel implants results in higher diode capacitance and increases inverter chain delay by approximately 20 ps/stage, but speeds less than 50 ps/stage should be obtained with L=0.3 mu m NMOS and L=0.4 mu m PMOS, both having effective channel lengths of approximately 0.2 mu m.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Digestion and Absorption of Dietary Protein (1990)

Dietary protein is normally assimilated in an efficient manner following the action of gastrointestinal proteases. A number of pathological conditions can alter this process, with deleterious nutritional consequences.
Automatic time stamp extraction system for home videos (2003)

Time stamps in videos play an important role in video clustering and retrieval. For digital camcorders, the time stamp is separately stored in the video stream using some specific bytes, thus it can be accessed easily. However, for analog camcorders, the time stamp is superimposed on the video frame and mixed into the video data, thus we cannot extract it directly. Furthermore, extraction of time stamp in home videos is much harder than that of ordinary videotext due to the poor quality of the video. We propose a robust and efficient time stamp detection and recognition system for analog home videos. To deal with the special difficulties, we propose two approaches, which can remarkably improve the overall system performance. The final outputs are shot boundaries with the corresponding time indices, which are detected and recognized by the proposed system. These results can be used as metadata for further video processing.
SURVEY AND SUMMARY: Puralpha: a multifunctional single-stranded DNA- and RNA-binding protein (2000)

Puralpha is a ubiquitous, sequence-specific DNA- and RNA-binding protein which is highly conserved in eukaryotic cells. Puralpha has been implicated in diverse cellular functions, including transcriptional activation and repression, translation and cell growth. Moreover, this protein has been shown to be involved in regulating several human viruses which replicate in the central nervous system (CNS), including human immunodeficiency virus type I (HIV-1) and JC virus (JCV). Puralpha exerts part of its activity by interacting with cellular proteins, including pRb, E2F, cyclin A, Sp1 and members of the Y-box family of proteins, including YB-1 and MSY1, as well as viral proteins such as polyomavirus large T-antigen and HIV-1 Tat. The ability of Puralpha to interact with its target DNA sequence and to associate with several viral and cellular proteins is modulated by RNA. Puralpha has also been shown to be involved in cell growth and proliferation. Its association with pRb, E2F and cyclin A coupled with its fluctuating levels throughout the cell cycle, position Puralpha as a crucial factor in the cell cycle. Moreover, microinjection studies demonstrate that Puralpha causes either a G(1) or G(2) arrest depending on the cell cycle time of injection. The gene encoding Puralpha has been localized to a human locus which is frequently deleted in myelogenous leukemias and other cancers and Puralpha gene deletions have been detected in many cases of lymphoid cancers. The following review details the structural characteristics of Puralpha, its family members and the involvement of this protein in regulating various cellular and viral genes, viral replication and cell growth.
Magnetically Induced Reconstruction of the Ground State in a Few-Electron Si Quantum Dot (2001)

We report unexpected fluctuations in the positions of Coulomb blockade peaks at high magnetic fields in a small Si quantum dot. The fluctuations have a distinctive sawtooth pattern: as a function of magnetic field, linear shifts of peak positions are compensated by abrupt jumps in the opposite direction. The linear shifts have large slopes, suggesting formation of the ground state with a nonzero angular momentum. The value of the momentum is found to be well defined, despite the absence of the rotational symmetry in the dot.
Kinetic studies on cationic ring-opening polymerization of 2-phenyl-1,2-oxaphospholane (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKinetic studies on cationic ring-opening polymerization of 2-phenyl-1,2-oxaphospholaneShiro Kobayashi, Masato Suzuki, and Takeo SaegusaCite this: Macromolecules 1984, 17, 1, 107–110Publication Date (Print):January 1, 1984Publication History Published online1 May 2002Published inissue 1 January 1984https://doi.org/10.1021/ma00131a018Request reuse permissionsArticle Views100Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (449 KB) Get e-Alertsclose Get e-Alerts
Recent Advances in Application of Electrodialysis with Bipolar Membranes for Organic Acid Recovery from Fermentation Broth (2016)

Fermentation has become a reliable, cost-competitive, feasible alternative for large-scale industrial production of many bulk and special organic acids. Electrodialysis with bipolar membranes (EDBM) technology was considered as a ‘‘green’’ process for organic acid separation from fermentation broth, which has distinct advantages over other electrolysis- based technologies. However, review on the new state on this field is limited. This paper provides an overview of recent progress in application of EDBM process for organic acid production from 2008 to the latest one, including EDBM process integration, application and maintenance. Especially, the influence of different operational factors on the performance of EDBM was systemically discussed. Furthermore, the gaps limiting large-scale field application of EDBM process were analyzed.
Port Wine Stains and the Response to Argon Laser Therapy (1980)

To date, no criteria exist for anticipating the response of a port wine stain to argon laser therapy. In an effort to determine such predictive factors, the preceding study was undertaken. Sixty-two patients, ages 7 to 66 years, with port wine stains were biopsied, had a small test area treated, and were evaluated after 4 months. A desirable result, defined by marked lightening of the lesion without scarring, occurred in 73 percent of the patients. Factors favoring a desirable result included age greater than 37 years, purple color, fraction of dermis occupied by vessels greater than 5 percent, mean vessel area greater than 2500 micrometers2, and percent of vessels containing erythrocytes greater than 15 percent. Furthermore, the degree of color change strongly correlated with these indices. Factors indicating an undesirable result included age less than 17 years, pink color, vascular area less than 2 percent, mean vessel area less than 1500 micrometers2, and percent of vessels containing erythrocytes less than 3 percent, Thus, if appropriate clinical and histological criteria are met port wine stains can successfully treated with argon laser therapy.
A class of generalized lattice filters (1980)

It is shown that the digital lattice filter utilized as a predictor in speech processing is a special case of a broad class of filters with identical properties in which the delay element is replaced by an arbitrary analog or digital all-pass filter. The performance of three filters in this class, the delay element and single-pole analog and digital all-pass sections, are compared for the special estimation application.
Detection of cancer cells in peripheral blood stem cells of women with breast cancer by RT-PCR and cell culture. (1996)

The benefit of high-dose therapy and blood stem cell reinfusion for women with high-risk breast cancer is currently under investigation. Contaminations of autologous blood stem cells with cancer cells have been described. Cancer micrometastases may be detected by immunocytochemistry, culture techniques and cytokeratin-19 mRNA reverse transcriptase PCR. Women with breast cancer received adjuvant HD-CTM with peripheral blood stem cell (PBSC) support after surgical therapy and 4 cycles conventional chemotherapy. Peripheral blood stem cells were mobilised by G-CsF and harvested after the third or fourth cycle of standard therapy. Aliquots of PBSC-collections (10(7)-2*10(7) cells) were subjected to CK19-mRNA reverse transcriptase PCR. RNA was extracted by standard methods and reverse transcription was performed with MMV-RT. Integrity of RNA was checked by coamplification of housekeeping sequences. Aliquots of the RT-mix were subjected to PCR-amplification with outer and inner primer pairs, subsequently. A second aliquot of 2*10(7) cells was cultured over 42 days in liquid culture. Cytospins were prepared weekly from cultured cells and evaluated by light microscopy with or without prior immunocytochemistry. Ten leukaphereses from 6 women were available for PCR-analysis and cell culture. Six leukaphereses were negative for CK19-mRNA and for detection of cancer cells by culture technique, two samples were positive for CK19-mRNA and culturally enriched cells and two samples were positive for CK19-mRNA and negative for cultured cancer cells. No sample was positive for cultured cells and negative for CK19-mRNA. Overall, the results corresponded in 80%. Two sensitive techniques for the detection of cancer micrometastases were applied to aliquots from 10 leukaphereses of six breast cancer patients with corresponding results in 80%. PCR-mediated detection of cancer cells was confirmed by culture technique and light microscopy, however, further comparison of CK19-PCR with standard techniques like cell culture and immunocytochemistry is still necessary.
Production of Hyaluronic Acid by a Streptococcal Strain in Batch Culture (1967)

A simple method for the production and preparation of hyaluronic acid (HA) is described. Three media were tested, which all supported relatively good yields of cells, but only in one of them were appreciable amounts of HA formed. In this medium, HA was produced during the logarithmic growth phase and showed a molecular weight of 7.3 x 10. HA prepared from 24-hr cultures of the same organism had a molecular weight of only 2.6 x 10. The kinetics of HA production in batch culture were studied, as well as of cell production and glucose consumption.
Time Transfer by Laser Link: A complete analysis of the error budget, (2015)

International audience
A Generalized Technique for Spectral Analysis (1970)

A technique is presented to implement a class of orthogonal transformations on the order of pN log <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">p</inf> N operations. The technique is due to Good [1] and implements a fast Fourier transform, fast Hadamard transform, and a variety of other orthogonal decompositions. It is shown how the Kronecker product can be mathematically defined and efficiently implemented using a matrix factorization method. A generalized spectral analysis is suggested, and a variety of examples are presented displaying various properties of the decompositions possible. Finally, an eigenvalue presentation is provided as a possible means of characterizing some of the transforms with similar parameters.
The effects of mismatch in complex bandpass ΔΣ modulators (2002)

Mismatch between the real and imaginary channels of a complex system is examined and equations are presented that show the relationship between mismatch and image rejection. An example is given that demonstrates the effects of mismatch on the properties of a complex filter. These results are applied to the design of a fourth-order complex bandpass /spl Delta//spl Sigma/ modulator and a technique is discussed that alleviates the negative effects of mismatch on modulator performance. The technique modifies a modulator's noise transfer function by placing a notch in its image band, giving an SNR performance improvement of approximately 15 dB (2.5 bits) over an unmodified modulator. The practical implementation of this technique is discussed.
A Novel<scp>L</scp>-Amino Acid Ligase from<i>Bacillus subtilis</i>NBRC3134, a Microorganism Producing Peptide-Antibiotic Rhizocticin (2009)

L-amino acid ligase catalyzes the formation of an alpha-peptide bond from unprotected L-amino acids in an ATP-dependent manner, and this enzyme is very useful in efficient peptide production. We performed enzyme purification to obtain a novel L-amino acid ligase from Bacillus subtilis NBRC3134, a microorganism producing peptide-antibiotic rhizocticin. Rhizocticins are dipeptide or tripeptide antibiotics and commonly possess L-arginyl-L-2-amino-5-phosphono-3-cis-pentenoic acid. The purification was carried out by detecting L-arginine hydroxamate synthesis activity, and a target enzyme was finally purified 1,280-fold with 0.8% yield. The corresponding gene was then cloned and designated rizA. rizA was 1,242 bp and coded for 413 amino acid residues. Recombinant RizA was prepared, and it was found that the recombinant RizA synthesized dipeptides whose N-terminus was L-arginine in an ATP-dependent manner. RizA had strict substrate specificity toward L-arginine as the N-terminal substrate; on the other hand, the substrate specificity at the C-terminus was relaxed.
Controlled Precipitation of Sparingly Soluble Phosphate Salts Using Enzymes. II. Precipitation of Struvite (2009)

A novel methodology for the synthesis of magnesium ammonium phosphate (MgNH4PO4·6H2O, MAP or struvite) through precipitation from supersaturated solutions was developed. The development of supersaturation with respect to struvite was catalyzed by the enzymatic decomposition of sodium polyphosphate salts. Solutions containing magnesium and ammonium ions and either sodium tripolyphosphate (Na5P3O10, STP) with alkaline phosphatase or sodium trimetaphosphate (Na3P3O9, STMP) with acid phosphatase were used for the synthesis of MAP. The experiments were done at 25 °C, and the pH was adjusted at 9.80 for the alkaline and at pH 7.50 for the acid phosphatase containing solutions, respectively. The precipitated struvite crystals exhibited a rather irregular morphology. In all cases and as a result of the enzymic activity, the inorganic orthophosphate concentration in solution increased with time reaching the threshold for the spontaneous precipitation of struvite. The supersaturation at the onset of the precipitation process was significantly higher in comparison to the respective values in solutions made by mixing the components of the precipitating solid (magnesium, ammonium, and orthophosphate solutions). Moreover, the rates of precipitation in the latter solutions were significantly higher. Past the supersaturation threshold, struvite crystals formed at rates increasing with the solution supersaturation. The presence of suspended particles affected both nucleation and crystal growth of struvite significantly in the presence of the enzymes tested. More specifically, in the presence of silicate sand the formation of struvite was promoted, yielding higher rates of precipitation. At the same solution conditions, the presence of suspended soil particles resulted in lower rates of precipitation. In both cases, the formation of struvite in the presence of suspended particles formed bridges between neighboring particles. The proposed process is promising for applications in the consolidation of sand containing soils.
The Use of External Support in the Treatment of Low-Back Pain (1970)

The purpose of the study was to identify among the forty-plus types of support listed in the literature those which are being used in the care of problems of the low back today. Through the generous cooperation of the membership of The American Academy of Orthopaedic Surgeons this was accomplished. Eighty-six per cent of the indications were related to five types of support with the lumbosacral corset and the chairback (Knight) brace strongly predominant. The other types of support were the Williams brace, a body cast, and flexion cast. A general relationship between clinical condition and choice of support, as well as an impression of their function, were also identified. These data represent clinical opinions; no objective measurements were made. Controlled testing of actual effectiveness, identification of their precise functions, and a review of present limitations may restrict the list even further or, conversely, new designs may evolve. It should also be recognized, as many of the respondents indicated, that this review of external support prescription considered only one facet in the management of low-back pain.
Spent fuel disassembly hardware and other non-fuel bearing components: characterization, disposal cost estimates, and proposed repository acceptance requirements (1986)

There are two categories of waste considered in this report. The first is the spent fuel disassembly (SFD) hardware. This consists of the hardware remaining after the fuel pins have been removed from the fuel assembly. This includes end fittings, spacer grids, water rods (BWR) or guide tubes (PWR) as appropriate, and assorted springs, fasteners, etc. The second category is other non-fuel-bearing (NFB) components the DOE has agreed to accept for disposal, such as control rods, fuel channels, etc., under Appendix E of the standard utiltiy contract (10 CFR 961). It is estimated that there will be approximately 150 kg of SFD and NFB waste per average metric ton of uranium (MTU) of spent uranium. PWR fuel accounts for approximately two-thirds of the average spent-fuel mass but only 50 kg of the SFD and NFB waste, with most of that being spent fuel disassembly hardware. BWR fuel accounts for one-third of the average spent-fuel mass and the remaining 100 kg of the waste. The relatively large contribution of waste hardware in BWR fuel, will be non-fuel-bearing components, primarily consisting of the fuel channels. Chapters are devoted to a description of spent fuel disassembly hardware and non-fuel assembly components, characterization of activated components, disposal considerations (regulatory requirements, economic analysis, and projected annual waste quantities), and proposed acceptance requirements for spent fuel disassembly hardware and other non-fuel assembly components at a geologic repository. The economic analysis indicates that there is a large incentive for volume reduction.
Developing Converged Application using Open Source software (2009)

With evolution of telecommunication the demand for real time communication is increasing day by day in any enterprise (Converged) application . For example as soon as user makes any bank transaction using bank's online portal the portal should send a SMS to phone registered against that user. As soon as there is checkout in shopping portal by a customer the details of Order should reach to administrator either as a SMS or as a phone call (using the text to speech conversion technology). As soon as there is transaction on Credit Card, SMS should be sent to user. Its not limited to passing the information one way but interactive communication that should take place between the communication device and web application like unless and until user approves of credit card transaction by his/her phone the credit card is not charged! In this paper we present the Mobicents Open Source Platform for development of Converged Application.
Voltage polarity dependent low-power and high-speed resistance switching in CoO resistance random access memory with Ta electrode (2008)

Structural and resistance switching properties were investigated in the CoO resistance random access memory (RRAM) with the Ta electrode. The intermediate layer consisting of Co and Ta oxides was confirmed at the interface by the transmission electron microscopy and electron energy loss spectroscopy. The great affinity with oxygen in Ta together with a high resistivity of the Ta oxide improves the operational performance of RRAM. The controllability of the resistance after forming and the low-current operation property were substantially improved by using the load resistor connected in series with CoO RRAM with the Ta electrode. The reset current less than 0.2 mA and the switching speed faster than 20 ns were demonstrated.
Intelligent and Standardized Parking Solution (2009)

Summary Due to the increasing number of vehicles and urbanizations, managing parking has become an issue. One main reason is that the current infrastructure facilities are not efficient enough to manage increasing demand. Although there are several systems to solve this issue, standardization and interoperability has not been achieved yet. Therefore everyone has to subscribe or use parking systems according to the service provider’s proprietary systems. On the other hand, providing prior information about idling parking lots and navigation towards the idling parking lot in controlled entrance parking blocks, and preventing illegal parking and automatically enforcing parking regulations in free entrance parking lots hasn’t also been achieved yet. In this paper we will introduce a novel RFID tag architecture and composition that can solves the most of the current parking issues while realizing potential benefits in intelligent transportation systems. The proposed solution allows real time, efficient, effective and hassle free parking systems, enables dynamic parking management, provides information and directions on idling lots, automate collecting of charges and prevents illegal parking in both free entrance and controlled entrance parking lots.