gebhart/patrepeval huggingface dataset:
The effect of logic block architecture on FPGA performance (1992)

This authors explore the effect of logic block architecture on the speed of a field-programmable gate array (FPGA). Four classes of logic block architecture are investigated: NAND gates, multiplexer configurations, lookup tables, and wide-input AND-OR gates. An experimental approach is taken, in which each of a set of benchmark logic circuits is synthesized into FPGAs that use different logic blocks. The speed of the resulting FPGA implementations using each logic block is measured. While the results depend on the delay of the programmable routing, experiments indicate that five- and six-input lookup tables and certain multiplexer configurations produce the lowest total delay over realistic values of routing delay. The fine grain blocks, such as the two-input NAND gate, exhibit poor performance because these gates require many levels of logic block to implement the circuits and hence require a large routing delay.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
THERMAL PERFORMANCE OF PANELS WITH HIGH DENSITY, RANDOMLY ORIENTED STRAW BALES (2018)

ABSTRACT This paper describes the hot-box testing (based on ASTM C1363-11) of seven straw bale wall panels to obtain their thermal conductivity values. All panels were constructed with stacked bales and cement-lime plaster skins on each side of the bales. Four panels were made with traditional, 2-string field bales of densities ranging from 89.5 kg/m 3 –131 kg/m 3 and with the bales on-edge (fibres perpendicular to the heat flow). Three panels were made with manufactured high-density bales (291 kg/m 3 –372 kg/m 3 ). The fibres of the manufactured bales were randomly oriented. The key conclusion of this paper is that within the experimental error, there is no difference in the thermal conductivity value for panels using normal density bales and manufactured high density bales up to a density of 333 kg/m 3 . However, because of lack of precision of the hot-box, no conclusions can be made on the true thermal conductivity of the high density bale panels. In addition, the panels tested were found to have significant voids between bales, and this is believed to have contributed to higher measured thermal conductivity values compared to those reported in the literature for normal density bale panels. Thermal properties may be affected for bales with higher densities than 333 kg/m 3 , therefore further testing is suggested.
Trefoil factor family domain peptides in the human respiratory tract (2000)

Trefoil factor family domain peptides (TFF) are thought to be involved in mucosal epithelial restitution and wound healing of the gastrointestinal tract and are up-regulated in ulceration and in a variety of solid tumours. It was hypothesized that TFFs are also expressed on mucosal surfaces of the human respiratory tract. Lung tissue, nasal polyps, and sputum samples from seven patients with cystic fibrosis (CF), two with chronic and acute bronchitis, and non-dysplastic material from two cases of bronchial adenocarcinoma were analysed for TFF expression by immunohistochemistry, immunofluorescence, western blot and RT-PCR. Expression of TFF1 and TFF3 was observed in material from all patients. TFFs were localized in goblet and ciliated cells, as well as in some submucosal cells of tracheobronchial tissues and nasal polyps from normal and CF individuals. In sputa of patients with CF and with chronic or acute bronchitis, TFF1 and TFF3 were detected by western blotting. Freshly cultivated nasal epithelial cells transcribed and secreted TFFs and mucins, whereas nasal cells cultivated for 6 weeks still expressed mucins, but not TFFs. Secreted TFFs and mucins also bound to the surface of Staphylococcus aureus in infected CF airways. In conclusion, TFF1 and TFF3 are expressed and secreted in normal and inflamed airways. The association of TFFs with bacteria may contribute to the anti-microbial mucociliary defence system.
PROMIS Physical Function Computer Adaptive Test Compared With Other Upper Extremity Outcome Measures in the Evaluation of Proximal Humerus Fractures in Patients Older Than 60 Years (2015)

This study suggests using the PROMIS PF CAT as a sole PF outcome measure can yield an assessment of upper extremity function similar to those provided by traditional PF measures, while substantially reducing patient assessment time.
Rheololgy of Mesomorphic Solutions of Cellulose (1980)

Abstract Solutions of cellulose were prepared with liquid crystal phases by mixing cellulose, water and N‐methylmorpholine N‐oxide under appropriate conditions of concentration and temperature. Their rheological behaviour was studied using capillary rheometry. For each solution, flow curves were plotted over a temperature range of 70‐‐120°C, and a shear rate range of 1‐‐500 sec −1 . Considerable agreement was found between the rheological and optical characterisations of the anisotropic‐isotropic transition temperature T *. The variations of the strain rate sensitivity parameter m were studied over a large temperature range and particularly around T *. These results, new for cellulose solutions, provide some valuable information about the rheology of anisotropic polymer fluids.
Multidimensional Tandem Capillary Gas Chromatography System for the Analysis of Real Complex Samples. Part I: Development of a Fully Automated Tandem Gas Chromatography System (1998)

A fully-automated, tandem high-resolution gas chromatography (HRGC-HRGC) system is developed for multitransfer operations.
Identifying and Ranking Dominating Product Features using NLP Technique (2015)

As internet usage increased users uses internet not only to access and search information but also at the same time able to spread and publish own idea, sentiments, knowledge via different number of websites. Different websites encourage their user to write their views in the form of electronic text. This system increasing user-written electronic text in the world of internet, large numbers of user opinions are available on World Wide Web. User review contains important information, which is beneficial for customer as well as retailer. These reviews are in scattered format so extracting important data from this large corpus is time consuming work. Here developing a system which will automatically identify and rank the product features. The Stanford parser is used for identify product features. Sentence level sentiment classification is used for identify sentiment of each sentence separately, Sentiment Classifier is used for classifying each sentence, and finally a probabilistic ranking algorithm is used to rank the product features.
Dysregulation of Kv3.4 Channels in Dorsal Root Ganglia Following Spinal Cord Injury (2015)

Spinal cord injury (SCI) patients develop chronic pain involving poorly understood central and peripheral mechanisms. Because dysregulation of the voltage-gated Kv3.4 channel has been implicated in the hyperexcitable state of dorsal root ganglion (DRG) neurons following direct injury of sensory nerves, we asked whether such a dysregulation also plays a role in SCI. Kv3.4 channels are expressed in DRG neurons, where they help regulate action potential (AP) repolarization in a manner that depends on the modulation of inactivation by protein kinase C (PKC)-dependent phosphorylation of the channel's inactivation domain. Here, we report that, 2 weeks after cervical hemicontusion SCI, injured rats exhibit contralateral hypersensitivity to stimuli accompanied by accentuated repetitive spiking in putative DRG nociceptors. Also in these neurons at 1 week after laminectomy and SCI, Kv3.4 channel inactivation is impaired compared with naive nonsurgical controls. At 2-6 weeks after laminectomy, however, Kv3.4 channel inactivation returns to naive levels. Conversely, Kv3.4 currents at 2-6 weeks post-SCI are downregulated and remain slow-inactivating. Immunohistochemistry indicated that downregulation mainly resulted from decreased surface expression of the Kv3.4 channel, as whole-DRG-protein and single-cell mRNA transcript levels did not change. Furthermore, consistent with Kv3.4 channel dysregulation, PKC activation failed to shorten the AP duration of small-diameter DRG neurons. Finally, re-expressing synthetic Kv3.4 currents under dynamic clamp conditions dampened repetitive spiking in the neurons from SCI rats. These results suggest a novel peripheral mechanism of post-SCI pain sensitization implicating Kv3.4 channel dysregulation and potential Kv3.4-based therapeutic interventions.
Sensorless position estimation and control of permanent-magnet synchronous motors using a saturation model (2015)

International audience
Synthesis and Assessment of Peptide Gd–DOTA Conjugates Targeting Extradomain B Fibronectin for Magnetic Resonance Molecular Imaging of Prostate Cancer (2017)

Contrast enhanced MRI is commonly used in imaging and treatment planning of prostate cancer. However, no tumor targeting contrast agent is commercially available for accurate detection and characterization of prostate cancer with MRI. Extradomain B fibronectin (EDB-FN), an oncoprotein present in aggressive tumors, is a promising molecular target for detection and stratification of high-risk prostate cancer. In this work, we have identified four small peptides (GVK, IGK, SGV, and ZD2) specific to EDB-FN for tumor targeting. In silico simulations of the binding patterns and affinities of peptides to the EDB protein fragment revealed different binding site to different peptide in the ligand-receptor interactions. Tumor specificity and organ distribution of the peptides were assessed using fluorescence imaging in male mice bearing PC-3 human prostate cancer xenografts. Targeted contrast agents were synthesized by conjugating tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) to the peptides in the solid phase, followed by complexation with GdCl<sub>3</sub>. The contrast agents were characterized by MALDI-TOF mass spectrometry and relaxivity measurements. All four peptide Gd-DOTA conjugates resulted in robust tumor contrast enhancement in MR imaging of the PC3 mouse prostate cancer model. The peptide Gd-DOTA conjugates specific to EDB-FN are promising targeted small molecular macrocyclic contrast agents for MR molecular imaging of prostate cancer.
Application of Two-Part Statistics for Comparison of Sequence Variant Counts (2011)

Investigation of microbial communities, particularly human associated communities, is significantly enhanced by the vast amounts of sequence data produced by high throughput sequencing technologies. However, these data create high-dimensional complex data sets that consist of a large proportion of zeros, non-negative skewed counts, and frequently, limited number of samples. These features distinguish sequence data from other forms of high-dimensional data, and are not adequately addressed by statistical approaches in common use. Ultimately, medical studies may identify targeted interventions or treatments, but lack of analytic tools for feature selection and identification of taxa responsible for differences between groups, is hindering advancement. The objective of this paper is to examine the application of a two-part statistic to identify taxa that differ between two groups. The advantages of the two-part statistic over common statistical tests applied to sequence count datasets are discussed. Results from the t-test, the Wilcoxon test, and the two-part test are compared using sequence counts from microbial ecology studies in cystic fibrosis and from cenote samples. We show superior performance of the two-part statistic for analysis of sequence data. The improved performance in microbial ecology studies was independent of study type and sequence technology used.
Moving Breast Cancer Therapy up a Notch (2018)

Breast cancer is the second most common malignancy, worldwide. Treatment decisions are based on tumor stage, histological subtype, and receptor expression and include combinations of surgery, radiotherapy, and systemic treatment. These, together with earlier diagnosis, have resulted in increased survival. However, initial treatment efficacy cannot be guaranteed upfront, and these treatments may come with (long-term) serious adverse effects, negatively affecting a patient's quality of life. Gene expression-based tests can accurately estimate the risk of recurrence in early stage breast cancers. Disease recurrence correlates with treatment resistance, creating a major need to resensitize tumors to treatment. Notch signaling is frequently deregulated in cancer and is involved in treatment resistance. Preclinical research has already identified many combinatory therapeutic options where Notch involvement enhances the effectiveness of radiotherapy, chemotherapy or targeted therapies for breast cancer. However, the benefit of targeting Notch has remained clinically inconclusive. In this review, we summarize the current knowledge on targeting the Notch pathway to enhance current treatments for breast cancer and to combat treatment resistance. Furthermore, we propose mechanisms to further exploit Notch-based therapeutics in the treatment of breast cancer.
A Mutation (Pro-30 to Leu) in<i>CYP</i>21 Represents a Potential Nonclassic Steroid 21-Hydroxylase Deficiency Allele (1991)

The mild nonclassic form of steroid 21-hydroxylase deficiency is one of the most common autosomal recessive disorders in humans, occurring in almost 1% of caucasians and about 3% of Ashkenazi Jews. Many patients with this disorder carry a Val-281----Leu missense mutation in the CYP21 gene. This and most other mutations causing 21-hydroxylase deficiency are normally present in the CYP21P pseudogene and have presumably been transferred to CYP21 by gene conversion. To identify other potential nonclassic alleles, we used recombinant vaccinia virus to express two mutant enzymes carrying the mutations Pro-30----Leu (normally present in CYP21P) and Ser-268----Thr (considered a normal polymorphism of CYP21). Whereas the activity of the protein carrying the Ser----Thr mutation was indeed indistinguishable from the wild type, the enzyme with the Pro----Leu substitution had 60% of wild-type activity for 17-hydroxyprogesterone and about 30% of normal activity for progesterone when assayed in intact cells. When kinetic analysis of the latter mutant enzyme was performed in cellular lysates, the first order rate constants (maximum velocity/dissociation constant) for both substrates were reduced 10- to 20-fold compared with those for the wild-type enzyme. Pro-30 is conserved in many microsomal P450 enzymes and may be important for proper orientation of the enzyme with respect to the aminoterminal transmembrane segment. The Pro----Leu mutation was present in 5 of 18 patients with nonclassic 21-hydroxylase deficiency, suggesting that this mutation indeed acts as a nonclassic deficiency allele.
Credit-based fair queueing (CBFQ): a simple service-scheduling algorithm for packet-switched networks (2001)

This paper proposes a simple rate-based scheduling algorithm for packet-switched networks. Using a set of counters to keep track of the credits accumulated by each traffic flow, the bandwidth share allocated to each flow, and the size of the head-of-line (HOL) packets of the different flows, the algorithm decides which flow to serve next. Our proposed algorithm requires on average a smaller complexity than the most interesting alternative ones while guaranteeing comparable fairness, delay, and delay jitter bounds. To further reduce the complexity, a simplified version (CBFQ-F) of the general algorithm is also proposed for networks with fixed packet lengths, such as ATM, by relaxing the fairness bound by a negligibly small amount.
Macrophage phagocytosis of biodegradable microspheres composed of <scp>L</scp>‐lactic acid/glycolic acid homo‐ and copolymers (1988)

Abstract A variety of biodegradable microspheres were prepared from L‐lactic acid, DL‐lactic acid, or glycolic acid homopolymers and copolymers of different molecular weights and monomer compositions. Phagocytosis of the microspheres by mouse peritoneal macrophages was studied in cell culture system using scanning electron microscopy as well as light microscopy. The diameter of microspheres prepared was less than 2 μm, regardless of the starting polymers. No dependence of the chemical nature of starting polymers was observed on the extent of phagocytosis of the microspheres by macrophages. Precoating the microspheres with water‐soluble macromolecules such as proteins had great influence on phagocytosis by macrophages. It was demonstrated that precoating with bovine serum albumin and non‐proteinaceous macromolecules reduced the phagocytosis of microspheres, while bovine γ‐globulin, human fibronectin, bovine tuftsin, and gelatin precoating enhanced the phagocytosis. This trend was not influenced by the presence of serum. Only in the case of gelatin precoating, the phagocytosis was greatly enhanced by the presence of serum as compared to precoating with other proteins. Microscopic observation clearly indicated that the phagocytosed microspheres were gradually degraded in the macrophage interior with the incubation time, leading to release of a fluorescent dye encapsulated in the microspheres. The rate of microsphere degradation in cells could be controlled by changing the molecular weight and the monomer composition of the copolymers comprising the microspheres.
Internet of Things based system for Smart Kitchen (2018)

This paper provides insight to the dynamics that come with the emergence of IoT in the furniture and kitchen manufacturing industry. By implementing the concept of IoT companies are currently evaluating how internal knowledge and skillsets correspond to the new technical requirements that the emerging digital setting outlines and by directing internal research they are learning more about IoT and connected products as they proceed. One current major problem is that there are no open protocols that can connect all products regardless of supplier. Nevertheless, implementation of IoT does not solely involve technical aspects and companies are also faced with the dilemma on how to design and develop corresponding commercial processes. To this point early product implementations have arrived on the consumer markets and the future vision is to achieve full integration that imbeds connectivity and interaction among all products in the home.
FPGA-Controlled All-Solid-State Nanosecond Pulse Generator for Biological Applications (2012)

In vivo studies of tumor-cell apoptosis induced by nanosecond pulsed electric field require high-voltage nanosecond pulses delivered to the biological tissues. In this paper, a newly developed all-solid-state nanosecond pulse generator based on the Marx generator concept is proposed for this application. The generator comprises four parts: a dc charging power, a solid-state Marx circuit using metal-oxide-semiconductor field-effect transistors, a control circuit using a field-programmable gate array, and the load. This generator has the capability of producing repetitive pulses with a voltage up to 8 kV, pulsewidth of 200-1000 ns, rise time of 35 ns, and repetition rate of 1-1000 Hz with various resistive loads and 1-kV dc input voltage. The all-solid-state design makes the generator compact and reliable. Initial experiments were carried out to verify the performances of the proposed generator.
Transdermal Nicotine and Haloperidol in Tourette's Disorder (2001)

Transdermal nicotine was superior to placebo in reducing behavioral symptoms when patients were receiving an optimal dose of haloperidol, when the dose of haloperidol was reduced by 50%, and when the patch had been discontinued for 2 weeks. These findings confirm earlier open-label findings and suggest that combining nicotinic receptor modulation and neuroleptics could be a therapeutic option for the treatment of Tourette's disorder. While side effects limit chronic use of nicotine, it may be useful on a p.r.n. basis. Further clinical research is warranted to investigate the use of novel nicotinic receptor modulating agents with improved safety profiles over nicotine.
Suppression of Ongoing Experimental Autoimmune Encephalomyelitis by Neutralizing the Function of the p28 Subunit of IL-27 (2004)

IL-27 is a recently defined family member of the long-chain, four-helix bundle cytokines, which consist of EBI3, an IL-12p40-related protein, and p28, an IL-12p35-related polypeptide. The role of IL-27 in the regulation of experimental autoimmune encephalomyelitis has never been studied. We show in this study that neutralizing the in vivo function of IL-27 by Abs against IL-27 p28 rapidly suppressed an ongoing long-lasting disease in C57BL/6 mice. These Abs were then used to determine the mechanistic basis of disease suppression. We show in this study that IL-27 is involved not only in the polarization of naive T cells undergoing Ag-specific T cell activation, but also in promoting the proliferation and IFN-gamma production by polarized T cells, including the long term Th1 line that has been previously selected against the target encephalitogenic determinant. This may explain in part why neutralizing IL-27 suppresses an already established disease in a very rapid and significant manner.
Histologial and histochemical study on the steroid synthesizing cellular sites in the testes of a hillstream fish Schizothorax plagiostomus (1992)

Steroidogenic tissue in the testes of Schizothorax plagiostomus mainly consists of the interstitial leydig cells and lobule boundary cells. These cells vary greatly in their distribution in different parts of the same testis. Lipid histochemistry reveals that these cells accumulate abundant lipid droplets consisting of cholesterol and/or its esters, triglycerides and some phospholipids which are depleted during peak spermatogenesis.
Nanoparticledrug delivery enhances the cytotoxicity of hydrophobic–hydrophilic drug conjugates (2011)

We report a drug conjugation approach to concurrently load both hydrophobic and hydrophilic drugs into the same drug delivery nanocarrier in a precisely controllable manner. Using paclitaxel as a model hydrophobic drug and cisplatin as a model hydrophilic drug, we demonstrate the synthesis and characterization of a paclitaxel–cisplatin conjugate via a hydrolysable linker and its easy encapsulation by a lipid–polymer hybrid nanoparticle with controllable drug loading yield and drug release profile. The cytotoxicity of the resulting drug conjugate loaded nanoparticles against human ovarian cancer cells is investigated and compared to that of unencapsulated free drug conjugates. It is found that the cellular cytotoxicity of the hydrophobic–hydrophilic drug conjugates is significantly improved after being encapsulated into the nanoparticles. This is likely because the nanoparticles facilitate the intracellular entry of the amphiphilic drug conjugates and thus overcome their poor transport ability across the lipid bilayer structured cellular membranes.