gebhart/patrepeval huggingface dataset:
Upstream CpG island methylation of the <i>PAX3</i> gene in human rhabdomyosarcomas (2004)

PAX3 CpG island methylation appears to distinguish embryonal subtype of rhabdomyosarcoma from alveolar, and methylation at certain sites within this CpG island is inversely correlated with PAX3 expression. In addition to exemplifying developmental dysregulation, methylation of PAX3 has potential in the development of an epigenetic profile for the diagnosis of rhabdomyosarcoma.
Quantification of the Transmural Dynamics of Atrial Fibrillation by Simultaneous Endocardial and Epicardial Optical Mapping in an Acute Sheep Model (2015)

Atrial fibrillation substrates are dynamic 3-dimensional structures with a range of discordance between the epicardial and the endocardial tissue. The results of this study suggest that transmural propagation may play a role in atrial fibrillation maintenance mechanisms.
Palladium(0)-catalyzed direct cross-coupling reaction of allylic alcohols with aryl- and alkenylboronic acids (2008)

Allylic alcohols can be used directly for the palladium(0)-catalyzed allylation of aryl- and alkenylboronic acids with a wide variety of functional groups. A triphenylphosphine-ligated palladium catalyst turns out to be most effective for the cross-coupling reaction and its low loading (less than 1 mol%) leads to formation of the coupling product in high yield. The Lewis acidity of the organoboron reagents and poor leaving ability (high basicity) of the hydroxyl group are essential for the cross-coupling reaction. The reaction process is atom-economical and environmentally benign, because it needs neither preparation of allyl halides and esters nor addition of stoichiometric amounts of a base. Furthermore, allylic alcohols containing another unsaturated carbon-carbon bond undergo arylative cyclization reactions leading to cyclopentane formation.
Mechanism-based inhibition of lactoperoxidase by thiocarbamide goitrogens (1986)

The irreversible inactivation of bovine lactoperoxidase by thiocarbamide goitrogens was measured, and the kinetics were consistent with a mechanism-based (suicide) mode. Sulfide ion inactivated, 2-mercaptobenzimidazole-inactivated, and 1-methyl-2-mercaptoimidazole-inactivated lactoperoxidases have different visible spectra, suggesting different products were formed. The results support a mechanism in which reactive intermediates are formed by S-oxygenation reactions catalyzed by lactoperoxidase compound II. It is proposed that the reaction of electron-deficient intermediates with the heme prosthetic group is responsible for the observed spectral changes and inactivation by thiocarbamides.
Mating Incompatibility Among Populations of the South American Fruit Fly <I>Anastrepha fraterculus</I> (Diptera: Tephritidae) (2006)

Mating compatibility among different populations of the South American fruit y Anastrepha fraterculus (Wiedemann) was assessed through mating tests in pairwise combinations. Screened cages, inside a greenhouse, containing Citrus limon (L.) trees were used. Mating compatibility was determined using the index of sexual isolation. Most of the populations were noncompatible with each other and thus sexually isolated. Of these, Tucuma n (Argentina) and Piracicaba (Brazil) populations showed a lower degree of isolation, whereas the other tested combinations were highly isolated. Full mating compatibility was detected only between two Argentinean (Concordia and Tucuma n) and two Peruvian populations (La Molina and Piura La Molina). Flies were sexually active at different times: Tucuma n, Concordia, and Piracicaba populations presented an early morning peak, La Molina and Piura La Molina were active around midday, and Ibague (Colombia) were active late in the afternoon. Manipulation of light phase conditions to match the times of maximum sexual activity did not increase the compatibility between La Molina and Tucuma n. Based on these behavioral results, which conrm morphometric, genetic, and other evidence, the taxonomic revision of this cryptic species complex is warranted. One practical implication is that colonies of this pest to be used in any sterile insect technique approach should be derived from the target population or from a compatible population. Regional efforts should be initiated to determine the distribution of each subgroup and their relationship with each other in terms of compatibility.
Switching in organic polymer films (1974)

Memory and threshold switching processes are described, as observed in systems consisting of thin (∼0.5 μ) polymer films (polymethylmethacrylate, polystyrene, polyethylmethacrylate, polybutylmethacrylate) between inert electrodes (graphite, molybdenum, NESA glass). The memory off-state is highly linear, in contrast to the corresponding characteristics of multicomponent chalcogenide glasses. Switching speeds are probably similar or, at any rate, ≪10−7 sec.
Golgi Fragmentation Occurs in the Cells with Prefibrillar α-Synuclein Aggregates and Precedes the Formation of Fibrillar Inclusion (2002)

Amyloid-like fibrillar aggregates of intracellular proteins are common pathological features of human neurodegenerative diseases. However, the nature of pathogenic aggregates and the biological consequences of their formation remain elusive. Here, we describe (i) a model cellular system in which prefibrillar alpha-synuclein aggregates and fibrillar inclusions are naturally formed in the cytoplasm with distinctive kinetics and (ii) a tight correlation between the presence of prefibrillar aggregates and the Golgi fragmentation. Consistent with the structural abnormality of Golgi apparatus, trafficking and maturation of dopamine transporter through the biosynthetic pathway were impaired in the presence of alpha-synuclein aggregates. Reduction in cell viability was also observed in the prefibrillar aggregate-forming condition and before the inclusion formation. The fibrillar inclusions, on the other hand, showed no correlation with Golgi fragmentation and were preceded by these events. Furthermore, at the early stage of inclusion formation, active lysosomes and mitochondria were enriched in the juxtanuclear area and co-aggregate into a compact inclusion body, suggesting that the fibrillar inclusions might be the consequence of an attempt of the cell to remove abnormal protein aggregates and damaged organelles. These results support the hypothesis that prefibrillar alpha-synuclein aggregates are the pathogenic species and suggest that Golgi fragmentation and subsequent trafficking impairment are the specific consequence of alpha-synuclein aggregation.
Low-power and low-noise programmable frequency dividers in a 130 nm SiGe BiCMOS technology (2017)

Two programmable frequency dividers for fractional-N frequency synthesizers are presented. The input frequency range is from 1 GHz to 10 GHz for both circuits, which were manufactured in a 130 nm SiGe BiCMOS technology. The first divider (divider1) has divisor values ranging from 32 to 127 and operates with a single supply voltage VCC between 2.2 V and 4 V, while the divisor value range for the second one (divider2) is from 32 to 63 and the supply voltage operational range is between 3.0 V and 3.6 V. The divider1 and divider2 draw 100 mA from a 2.5 V supply and 26 mA from a 3V supply, respectively. The dividers' phase noise contribution referred to the output of a 10 GHz PLL is lower than -108 dBc/Hz at 10 kHz offset and -116.5 dBc/Hz at 1 MHz offset. This makes the dividers suitable for low-noise fractional-N phase-locked loops using a conventional CMOS phase-frequency detector.
Fate of Organic Nitrogen during Electrooxidation over Conductive Metal Oxide Anodes (2007)

The electrooxidation of nitrogen-containing molecules (urea, reactive dye blue 4, acetonitrile, formamide, guanidine, and pyridazine) over Pt−Ti and Ti/RuO2 anodes is investigated. The product distribution of the electrochemical mineralization of nitrogen is monitored. Nitrogen mineralization generally leads to inorganic pollutants (NH3/NH4+ and/or nitrite and nitrate ions). Amidic and aminic compounds were found to react according to both homogeneous (acid hydrolysis) and heterogeneous (direct electrooxidation) pathways, with a rate depending on the original state of oxidation of nitrogen. Heterocyclic and multiple-bond carbon−nitrogen molecules were converted but with negligible mineralization of nitrogen due to the stability of their first oxidation intermediates. The obtained results can be useful for the design of further treatment routes after electrooxidation or the definition of simultaneous strategies for inorganic pollutants elimination.
Comparison among digital current controllers applied to power factor correction boost converters (2009)

This paper proposes two digital predictive current controllers applied to power factor correction boost converters. A comparison among these two controllers and another one already presented in the literature is also made. These controllers have in common the possibility of operation in the discontinuous, mixed and continuous conduction modes. The control system's goal is to provide a high power factor and a low total harmonic distortion to the input current of the converter. The control laws and the structure of the proposed controllers are shown in details. Simulation and experimental results, together with waveforms quality indexes, are also shown, in order to analyze and compare the performance of the controllers.
Transtubular leakage of glomerular filtrate in human acute renal failure (1979)

Ten postcardiac surgical patients with acute renal failure (ARF) were infused with inulin and dextran 40. Plasma and urine were then submitted to gel-permeation chromatography to ascertain the apparent fractional clearance profile for the dextrans. Compared to normal volunteer controls, the fractional clearance profile was substantially elevated for dextran molecules in the Einstein-Stokes radius (r) range 20-40 A. For the smaller molecules (r = 20-28 A), fractional dextran clearance in ARF was frequently in excess of unity. A simple mass conservation model which assumes that the "true" fractional dextran clearance profile for the glomerulus (in Bowman's space) in ARF is the same as that for normal controls, when applied to the experimental observations, revealed that in ARF, on the average, 50% of filtered inulin is lost by tubular backleakage. Furthermore, the model permitted an estimate of the permeability properties of the damaged tubular wall. This indicated tubular permeability not unlike that of the normal glomerulus to dextran molecules with r less than 30 A, but relative impermeability to larger dextran molecules.
New developments in antiplatelet and antithrombotic therapy (1995)

Several agents which inhibit platelet aggregation (aspirin, ticlopidine, dipyridamole), and anticoagulants (vitamin K antagonists, unfractionated heparin, low molecular weight heparins and heparinoids) are in clinical use. The search for more effective antiaggregating agents has resulted in the development of clopidogrel, a chemical analogue of ticlopidine with minimal bone-marrow suppressing effects, thromboxane synthase inhibitors and receptor blockers, and antagonists of platelet receptor glycoproteins Ib and IIb/IIIa. In addition there is increasing therapeutic experience with chimeric monoclonal antibodies against the platelet receptors, glycoprotein IIb/IIIa, and, to a minor extent, with synthetic peptides or non-peptide inhibitors against the same receptors. Although new anticoagulants have become available, their efficacy has only been tested in animal models of thrombosis: tissue factor pathway inhibitor, factor Xa inhibitors (recombinant tick anticoagulant peptide, antistasin, natural pentasaccharide and DX-9065), recombinant thrombomodulin and recombinant protein C have been tested in this manner. Considerable clinical progress has been made with direct thrombin inhibitors, such as recombinant hirudin and hirulog which appear to be effective antithrombotic agents in patients. There is also clinical experience with argatroban, an arginine derivative which is a competitive antagonist to thrombin. However, PPACK, a tripeptide synthetic compound which irreversibly blocks the active catalytic site of thrombin, has not been investigated in the clinical setting.
Restoration of CFTR function in patients with cystic fibrosis carrying the F508del-CFTR mutation (2014)

Restoration of BECN1/Beclin 1-dependent autophagy and depletion of SQSTM1/p62 by genetic manipulation or autophagy-stimulatory proteostasis regulators, such as cystamine, have positive effects on mouse models of human cystic fibrosis (CF). These measures rescue the functional expression of the most frequent pathogenic CFTR mutant, F508del, at the respiratory epithelial surface and reduce lung inflammation in Cftr(F508del) homozygous mice. Cysteamine, the reduced form of cystamine, is an FDA-approved drug. Here, we report that oral treatment with cysteamine greatly reduces the mortality rate and improves the phenotype of newborn mice bearing the F508del-CFTR mutation. Cysteamine was also able to increase the plasma membrane expression of the F508del-CFTR protein in nasal epithelial cells from F508del homozygous CF patients, and these effects persisted for 24 h after cysteamine withdrawal. Importantly, this cysteamine effect after washout was further sustained by the sequential administration of epigallocatechin gallate (EGCG), a green tea flavonoid, both in vivo, in mice, and in vitro, in primary epithelial cells from CF patients. In a pilot clinical trial involving 10 F508del-CFTR homozygous CF patients, the combination of cysteamine and EGCG restored BECN1, reduced SQSTM1 levels and improved CFTR function from nasal epithelial cells in vivo, correlating with a decrease of chloride concentrations in sweat, as well as with a reduction of the abundance of TNF/TNF-alpha (tumor necrosis factor) and CXCL8 (chemokine [C-X-C motif] ligand 8) transcripts in nasal brushing and TNF and CXCL8 protein levels in the sputum. Altogether, these results suggest that optimal schedules of cysteamine plus EGCG might be used for the treatment of CF caused by the F508del-CFTR mutation.
THERMAL WAVE IMAGING OF CRACKS IN METALS (1983)

A comparitive thermal wave study (SPAM and OBD) has been done on cracks, slanted and closed, in metals. There is a good correlation between the experimental results and the theoretical calculations.
Generation of Human Monoclonal Antibodies Against Ganglioside Antigens and Their Applications in the Diagnosis and Therapy of Cancer (1996)

Different approaches to generating human monoclonal antibodies (MAbs) against tumor-associated ganglioside antigens have been carried out in several laboratories. A specific goal addressed by our laboratory is to produce human MAbs to several ganglioside antigens of relevance as therapeutic targets, such as the GM2, GD2, GD3 and GM3 gangliosides in melanoma. In vitro immunization of human B lymphocytes from normal donors was performed using liposomes containing gangliosides as the immunizing antigen combined with either complete tetanus toxoid or a synthetic peptide corresponding to a T helper epitope to stimulate in vitro immunization. Specific human anti-ganglioside antibodies were obtained, indicating that the antibody response found in vitro was antigen-driven. To overcome the widely reported problems concerning stability of immunoglobulin production by the antibody-secreting cell lines, a method of positive selection using GM3-coated magnetic beads has been developed in order to rescue unstable clones. Development of new methods to reproducibly generate ganglioside-specific human MAbs will amplify the possibilities for diagnostic and therapeutic applications.
Speech enhancement employing Laplacian-Gaussian mixture (2005)

A new, efficient speech enhancement algorithm (SEA) is developed in this paper. In this low-complexity SEA, a noisy speech signal is first decorrelated and then the clean speech components are estimated from the decorrelated noisy speech samples. The distributions of clean speech and noise signals are assumed to be Laplacian and Gaussian, respectively. The clean speech components are estimated either by maximum likelihood (ML) or minimum-mean-square-error (MMSE) estimators. These estimators require some statistical parameters derived from speech and noise. These parameters are adaptively extracted by the ML approach during the active speech or silence intervals, respectively. In addition, a voice activity detector (VAD) that uses the same statistical model is employed to detect whether the speech is active or not. The simulation results show that our SEA approach performs as well as a recent high efficiency SEA that employs the Wiener filter. The computational complexity of this algorithm is very low compared with existing SEAs with low computational complexity.
Music Listening: What is in the Air ? (1999)

The XXth century is full of technological inventions that made the very idea of a listening device possible, from the early gramophones to the latest portable mini disk players. What evolutions can we predict for the listening devices of the future, and how these evolutions will change the way we access and listen to music? In this chapter, we suggest that listening devices can be greatly enhanced by providing new forms of user controls which provide users with semantically preserving variations. These controls are intended to allow listeners different musical perceptions on a piece of music, by opposition to traditional listening, in which the musical media is played passively by some neutral device. The objective is both to increase the musical comfort of listeners, and, when possible, to provide listeners with smoother paths to new music (music they do not know, or do not like). This chapter illustrates this idea on a few examples of active listening projects conducted at Sony Computer Science Laboratory, Paris, based on the notion of constrained exploratory space. These constrained spaces suggest that the classical boundaries between composing, listening and mixing may be redefined, thereby assigning new roles to composers, sound engineers and listeners.
Intranasal vaccine trial for canine infectious tracheobronchitis (kennel cough). (1981)

Two field trials were conducted during periods of endemic (summer) and epizootic (winter) canine infectious tracheobronchitis activity to evaluate the efficacy of three intranasal vaccines in a closed commercial beagle breeding kennel. A trivalent vaccine containing Bordetella bronchiseptica, canine parainfluenza, and canine adenovirus-2 was administered at 3 weeks of age. The vaccine was 71.2% and 81.8% effective in decreasing the incidence of coughing during the winter and summer trials, respectively. The number of deaths was lower in each of the vaccine groups than in the placebo groups. No adverse reactions were observed with any of the intranasal vaccines.
Carbon Dots Rooted Agarose Hydrogel Hybrid Platform for Optical Detection and Separation of Heavy Metal Ions (2015)

A robust solid sensing platform for an on-site operational and accurate detection of heavy metal is still a challenge. We introduce chitosan based carbon dots rooted agarose hydrogel film as a hybrid solid sensing platform for detection of heavy metal ions. The fabrication of the solid sensing platform is centered on simple electrostatic interaction between the NH3+ group present in the carbon dots and the OH- groups present in agarose. Simply on dipping the hydrogel film strip into the heavy metal ion solution, in particular Cr6+, Cu2+, Fe3+, Pb2+, Mn2+, the strip displays a color change, viz., Cr6+→yellow, Cu2+→blue, Fe3+→brown, Pb2+→white, Mn2+→tan brown. The optical detection limit of the respective metal ion is found to be 1 pM for Cr6+, 0.5 μM for Cu2+, and 0.5 nM for Fe3+, Pb2+, and Mn2+ by studying the changes in UV-visible reflectance spectrum of the hydrogel film. Moreover, the hydrogel film finds applicability as an efficient filtration membrane for separation of these quintet heavy metal ions. The strategic fundamental feature of this sensing platform is the successful capability of chitosan to form colored chelates with transition metals. This proficient hybrid hydrogel solid sensing platform is thus the most suitable to employ as an on-site operational, portable, cheap colorimetric-optical detector of heavy metal ion with potential skill in their separation. Details of the possible mechanistic insight into the colorimetric detection and ion separation are also discussed.
Ionic attachment as a feasible approach to heterogenizing anionic solution catalysts. Carbonylation of methanol (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIonic attachment as a feasible approach to heterogenizing anionic solution catalysts. Carbonylation of methanolRussell S. Drago, Eric D. Nyberg, Anton El A'mma, and Alan ZombeckCite this: Inorg. Chem. 1981, 20, 3, 641–644Publication Date (Print):March 1, 1981Publication History Published online1 May 2002Published inissue 1 March 1981https://pubs.acs.org/doi/10.1021/ic50217a001https://doi.org/10.1021/ic50217a001research-articleACS PublicationsRequest reuse permissionsArticle Views187Altmetric-Citations49LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Extracting business logic from business process models (2010)

Business rules and business process management (BPM) are increasingly considered as complements towards the quest of better business process insight and control by researchers and practitioners. The important role of business rules in BPM is now widely accepted among application software producers, researchers and business process managers. This development resulted in extensive process maps created by many enterprises. Increasingly needed tool support for business rules management and modeling became a relevant element at the market of business application software. Although systems and organizational units involved in the business process were captured in process diagrams, business rules that govern them were often not explicitly included in the models. This paper suggests an extraction process for business rules identification from business process models. Applying this process introduces a structured approach and management aspects within rules discovery by focusing on rule sources that are important for the process goal and providing a rule structure.