gebhart/patrepeval huggingface dataset:
Distributed Algorithms for Multirobot Task Assignment With Task Deadline Constraints (2015)

We present distributed algorithms for multirobot task assignment where the tasks have to be completed within given deadlines. Each robot has a limited battery life and thus there is an upper limit on the amount of time that it has to perform tasks. Performing each task requires certain amount of time (called the task duration) and each robot can have different payoffs for the tasks. Our problem is to assign the tasks to the robots such that the total payoff is maximized while respecting the task deadline constraints and the robot's battery life constraints. Our problem is NP-hard since a special case of our problem is the classical generalized assignment problem (which is NP-hard). There are no known algorithms (distributed or centralized) for this problem with provably good guarantees of performance. We present a distributed algorithm for solving this problem and prove that our algorithm has an approximation ratio of 2. For the special case of constant task duration we present a distributed algorithm that is provably almost optimal. Our distributed algorithms are polynomial in the number of robots and the number of tasks. We also present simulation results to depict the performance of our algorithms. Note to Practitioners-In this paper, we present provably good multirobot task assignment algorithms, while considering practical constraints like task deadlines and limited battery life of robots. Such constraints are relevant in many applications including parts movement by robots in manufacturing, delivery of goods by unmanned vehicles, and search and rescue operations. Our solution is applicable to a group of heterogeneous robots with different suitability (i.e., payoffs) for different tasks. Our distributed approach is independent of the underlying robot communication network topology, and thus can be applied to a wide range of robot network deployments. Finally, our approach is easy to implement, has low communication requirements, and it is scalable, since its running time is linear in the number of robots and tasks.
Association of Clopidogrel Pretreatment With Mortality, Cardiovascular Events, and Major Bleeding Among Patients Undergoing Percutaneous Coronary Intervention (2012)

Among patients scheduled for PCI, clopidogrel pretreatment was not associated with a lower risk of mortality but was associated with a lower risk of major coronary events.
MINIREVIEW 7-HYDROXYLATED DERIVATIVES OF DEHYDROEPIANDROSTERONE: WHAT ARE THEY GOOD FOR? (1997)

In the late fifties and early sixties our group has found that 3beta,7alpha-dihydroxy-5-androsten-17-one (7alpha-hydroxy-dehydroepiandrosterone) is a natural constituent of human body fluids. Later, the enzyme activity responsible for its formation has been demonstrated in many animal and human tissues including the foetal ones. The physiological role of this and related steroids has not been understood well for decades. As late as in 1994 Morfin and his group have shown that 7alpha-hydroxy-dehydroepiandrosterone may be a locally active metabolite, responsible for recently discovered immunostimulatory or immunomodulatory effects of dehydroepiandrosterone.
Effects of Reproductive Hormones on Experimental Vaginal Candidiasis (2000)

Vulvovaginal candidiasis (VVC) is an opportunistic mucosal infection caused by Candida albicans that affects large numbers of otherwise healthy women of childbearing age. Acute episodes of VVC often occur during pregnancy and during the luteal phase of the menstrual cycle, when levels of progesterone and estrogen are elevated. Although estrogen-dependent experimental rodent models of C. albicans vaginal infection are used for many applications, the role of reproductive hormones and/or their limits in the acquisition of vaginal candidiasis remain unclear. This study examined the effects of estrogen and progesterone on several aspects of an experimental infection together with relative cell-mediated immune responses. Results showed that while decreasing estrogen concentrations eventually influenced infection-induced vaginal titers of C. albicans and rates of infection in inoculated animals, the experimental infection could not be achieved in mice treated with various concentrations of progesterone alone. Furthermore, progesterone had no effect on (i) the induction and persistence of the infection in the presence of estrogen, (ii) delayed-type hypersensitivity in primary-infected mice, or (iii) the partial protection from a secondary vaginal infection under pseudoestrus conditions. Other results with estrogen showed that a persistent infection could be established with a wide range of C. albicans inocula under supraphysiologic and near-physiologic (at estrus) concentrations of estrogen and that vaginal fungus titers or rates of infection were similar if pseudoestrus was initiated several days before or after inoculation. However, the pseudoestrus state had to be maintained for the infection to persist. Finally, estrogen was found to reduce the ability of vaginal epithelial cells to inhibit the growth of C. albicans. These results suggest that estrogen, but not progesterone, is an important factor in hormone-associated susceptibility to C. albicans vaginitis.
Autosomal Dominant Diabetes Arising From a Wolfram Syndrome 1 Mutation (2013)

We used an unbiased genome-wide approach to identify exonic variants segregating with diabetes in a multigenerational Finnish family. At least eight members of this family presented with diabetes with age of diagnosis ranging from 18 to 51 years and a pattern suggesting autosomal dominant inheritance. We sequenced the exomes of four affected members of this family and performed follow-up genotyping of additional affected and unaffected family members. We uncovered a novel nonsynonymous variant (p.Trp314Arg) in the Wolfram syndrome 1 (WFS1) gene that segregates completely with the diabetic phenotype. Multipoint parametric linkage analysis with 13 members of this family identified a single linkage signal with maximum logarithm of odds score 3.01 at 4p16.2-p16.1, corresponding to a region harboring the WFS1 locus. Functional studies demonstrate a role for this variant in endoplasmic reticulum stress, which is consistent with the β-cell failure phenotype seen in mutation carriers. This represents the first compelling report of a mutation in WFS1 associated with dominantly inherited nonsyndromic adult-onset diabetes.
Immunoreceptor tyrosine‐based activation motif phosphorylation during engulfment of <i>Neisseria gonorrhoeae</i> by the neutrophil‐restricted CEACAM3 (CD66d) receptor (2003)

Gonorrhea is characterized by a purulent urethral or cervical discharge consisting primarily of neutrophils associated with Neisseria gonorrhoeae. These interactions are facilitated by gonococcal colony opacity-associated (Opa) protein binding to host cellular CEACAM receptors. Of these, CEACAM3 is restricted to neutrophils and contains an immunoreceptor tyrosine-based activation motif (ITAM) reminiscent of that found within certain phagocytic Fc receptors. CEACAM3 was tyrosine phosphorylated by a Src family kinase-dependent process upon infection by gonococci expressing CEACAM-specific Opa proteins. This phosphorylation was necessary for efficient bacterial uptake; however, a less efficient uptake process became evident when kinase inhibitors or mutagenesis of the ITAM were used to prevent phosphorylation. Ligated CEACAM3 was recruited to a cytoskeleton-containing fraction, intense foci of polymerized actin were evident where bacteria attached to HeLa-CEACAM3, and disruption of polymerized actin by cytochalasin D blocked all bacterial uptake by these cells. These data support a model whereby CEACAM3 can mediate the Opa-dependent uptake of N. gonorrhoeae via either an efficient, ITAM phosphorylation-dependent process that resembles phagocytosis or a less efficient, tyrosine phosphorylation-independent mechanism.
DeepN-JPEG: A Deep Neural Network Favorable JPEG-based Image Compression Framework (2018)

As one of most fascinating machine learning techniques, deep neural network (DNN) has demonstrated excellent performance in various intelligent tasks such as image classification. DNN achieves such performance, to a large extent, by performing expensive training over huge volumes of training data. To reduce the data storage and transfer overhead in smart resource-limited Internet-of-Thing (IoT) systems, effective data compression is a “must-have” feature before transferring real-time produced dataset for training or classification. While there have been many well-known image compression approaches (such as JPEG), we for the first time find that a human-visual based image compression approach such as JPEG compression is not an optimized solution for DNN systems, especially with high compression ratios. To this end, we develop an image compression framework tailored for DNN applications, named “DeepN-JPEG”, to embrace the nature of deep cascaded information process mechanism of DNN architecture. Extensive experiments, based on “ImageNet” dataset with various state-of-the-art DNNs, show that “DeepN-JPEG” can achieve $\sim 3.5$× higher compression rate over the popular JPEG solution while maintaining the same accuracy level for image recognition, demonstrating its great potential of storage and power efficiency in DNN-based smart IoT system design.
In vitro controlled release of bupivacaine from albumin microspheres and a co-matrix formed by microspheres in a poly(lactide-co-glycolide) film (2000)

Albumin microspheres cross-linked with glutaraldehyde and loaded with bupivacaine, a local anaesthetic, were synthesized (138 +/- 59 microm diameter). A matrix formed by bupivacaine-loaded microspheres in a poly(lactide-co-glycolide) film was prepared in order to improve the controlled release of the drug. In vitro release of the drug was determined in phosphate buffer at 37 degrees C in the absence and in the presence of protease type VIII to mimic a biological system. The effect of temperature and protease on bupivacaine as a function of time was examined; both of them cause a degradative effect on the drug. A rapid release (60 +/- 8% of the drug) takes place at 1 h, and maximum release is found at 50 +/- 6 h from microspheres with swelling. In the presence of protease, maximum release of bupivacaine from microspheres is found at 28 +/- 2 h; the microspheres disappear at 8 days. Inclusion of bupivacaine-loaded microspheres in a poly(lactide-co-glycolide) film causes a slower release of the drug, up to 18 days, with swelling. In the presence of protease, the polymer protects bupivacaine-loaded microspheres from degradation, which takes place at 20 days.
Local bandwidth constrained fast inverse motion compensation for DCT-domain video transcoding (2002)

Discrete cosine transform (DCT) based digital video coding standards, such as MPEG and H.26x, are becoming more widely adopted for multimedia applications. Since the standards differ in their format and syntax, video transcoding, where a compressed video bit-stream is converted from one format to another, is of interest for purposes such as channel bandwidth adaptation and video composition. DCT-domain video transcoding is generally more efficient than spatial-domain transcoding. However, since the data is organized block by block in the DCT domain, inverse motion compensation becomes the bottleneck for DCT-domain methods. We propose a novel local bandwidth constrained fast inverse motion compensation algorithm operating in the DCT domain. Relative to Chang's algorithm, we achieve computational improvement of 25%-55% without visual degradation. A by-product of our algorithm is a reduction of blocking artifacts in very low bit-rate compressed video sequences. The proposed algorithm can be combined with other reported fast methods for more computational savings. We also present a look-up-table (LUT) based implementation method by modeling the statistical distribution of the DCT coefficients in natural images and video sequences. By this method, we obtain a further 31%-48% improvement in computation. The memory requirement of the LUT is about 800 kB, which is reasonable. Moreover, the LUT can be shared by multiple DCT-domain video processing applications running on the same computer or video server.
Studies on Sulfonylurea Derivatives. I (1959)

A derivative of sulfonylurea, 1-p-tolylsulfonyl-3-butylurea (D-860), is generally used as a hypoglycemic drug for oral administration. A process for the syntheses of sulfonylurea and sulfonylthiourea was considered and a new method whereby D-860 is obtained in economically advantageous manner via sulfonylthiourea was established. The reaction is effected by heating potassium salt of toluenesulfonamide and butyl isothiocyanate in benzene system solvent and 1-p-tolylsulfonyl-3-butylthiourea so formed is oxidized with hydrogen peroxide. The yield is extremely good, being 95% calculated from the sulfonamide. About 90 kinds of the derivatives of these compounds were also prepared by the same process.
Synthesis of a thiophene analogue of kuanoniamine A (2001)

Synthesis of 9-methoxycarbonyl-7H-[1]benzothieno[4,5,6-ij][2,7]naphthyridin-7-one (3)—an analogue of kuanoniamine A (1)—via hetero Diels–Alder reaction of crotonaldehyde N,N-dimethylhydrazone with 2-methoxycarbonylbenzo[b]thiophene-4,7-dione and subsequent annelation, is described. The Diels–Alder reaction produced only the adduct with the desired regiochemistry, the structure of which was verified by 2D-NMR experiments.
Dewetting Photocontrol of Poly(styrene) Thin Films by a Photocrosslinkable Monolayer in Thermal Nanoimprint Lithography (2009)

In this article, we investigated dewetting behaviors of monodisperse-poly(styrene) thin films on a photocrosslinkable monolayer bearing a benzophenone moiety affected by ultraviolet light exposure dose, irradiation wavelength, and molecular weight. The thermally induced dewetting was suppressed by UV exposure at either 365-nm exposure dose of 200 J cm-2 or 254-nm exposure dose of 1.0 J cm-2. The dewetting behaviors were induced for low-molecular-weight poly(styrene) of the weight-average molecular weight (MW) 2,200 g mol-1 and not observed for poly(styrene) of more than MW = 10,800 g mol(sup>-1. The gel permeation chromatography analysis indicated that the thermally induced dewetting behaviors were not responsible for photochemistry of poly(styrene) such as depolymerization and disproportionation and responsible for monolayer photochemistry of the benzophenone moiety grafting poly(styrene) at the polymer/monolayer interface.
Numerical calculations of residual–stress relaxation in quenched plates (1985)

AbstractAbstractMethods of thermal stress relief such as stretching and compression are compared for different thermal and mechanical properties during quenching. The heat equation for a simple geometric model, such as an infinite plate, is solved with an experimental surface conductance and a step–by–step method of determining the temperature field in the thickness of the plate. This field is introduced as data for the uncoupled thermal elastic–plastic model for quenching. In the calculation of the plastic–strain path, the thermal and mechanical properties are considered as temperature dependent for a homogeneous and isotropic material. Good agreement is found between the calculated residual stresses and experimental values for an aluminium alloy and a stainless steel. The predicted residual–stress distributions and strain history are then used as data for the numerical simulation of stress–relief methods with an incremental integration of the Prandtl–Reuss equation. This analysis allows the observation of the effects of small variations in mechanical properties during quenching on the residual–stress field after mechanical stress relief and the theoretical comparison of different processes.MST/6
Bacillus asahii sp. nov., a novel bacterium isolated from soil with the ability to deodorize the bad smell generated from short-chain fatty acids (2004)

In a screening campaign to isolate strains with the ability to remove the bad smell associated with animal faeces, strain MA001(T) was isolated from a soil sample obtained from Shizuoka prefecture, Japan. The isolate grew at pH 6-9 but not at pH 10. Cells were Gram-positive, straight rods with peritrichous flagella and produced ellipsoidal spores. The isolate was positive for catalase and oxidase tests but negative for indole production, deamination of phenylalanine and H(2)S production. The isolate did not produce acid from any carbohydrates tested and could not grow in more than 2 % NaCl. The DNA G+C content was 39.4 mol%. The cellular fatty acids profile consisted of significant amount of C(15) branched-chain fatty acids, iso-C(15 : 0) and anteiso-C(15 : 0). Phylogenetic analysis based on 16S rRNA gene sequencing indicated that strain MA001(T) was closely related to Bacillus simplex and Bacillus psychrosaccharolyticus. DNA-DNA hybridization revealed a low relatedness of the isolate to several phylogenetically close neighbours (less than 9 %). On the basis of the phenotypic characteristics observed, phylogenetic data based on 16S rRNA gene sequencing and DNA-DNA relatedness data, it is concluded that the isolate should be classified as representing a novel species, for which the name Bacillus asahii is proposed. The type strain is MA001(T) (=JCM 12112(T)=NCIMB 13969(T)).
The changing epidemiology of multiple births in the United States (2003)

It is important to understand the changing epidemiology of multiple births, especially for women at highest risk (advanced maternal age, white race, Northeast residents). The attribution of infertility management requires further study. The differential birth weight-specific infant mortality for singletons and multiples demonstrates the importance of stratifying by plurality when assessing perinatal outcomes.
Primary amine coding as a path to comparative proteomics (2006)

Various isotope coding strategies are being used today in the field of comparative proteomics. This article specifically reviews the strengths and limitations of various N-termini-directing strategies. N-termini-directed coding strategy allows for use of different chromatographic enrichment techniques. Since N-termini-directed coding strategies are global in nature, they can be utilized in studying PTMs as well as protein expression. Using different N-termini-directed coding strategies, both relative and absolute quantification of proteins can be achieved either in the MS mode or in the MS/MS mode. The review ends with the conclusion that significant improvements have been made in the last decade. Among various issues, a need still exists for a better understanding of the kinetic issues in proteomics, relative protein pool sizes for different proteins and the issue of stimulus-induced changes in protein aggregation. Another critical issue that needs to be addressed in great detail is the role of PTMs in regulation.
Structure and function of Humicola insolens family 6 cellulases: structure of the endoglucanase, Cel6B, at 1.6 Å resolution (2000)

Cellulases are traditionally classified as either endoglucanases or cellobiohydrolases on the basis of their respective catalytic activities on crystalline cellulose, which is generally hydrolysed more efficiently only by the cellobiohydrolases. On the basis of the Trichoderma reesei cellobiohydrolase II structure, it was proposed that the active-site tunnel of cellobiohydrolases permitted the processive hydrolysis of cellulose, whereas the corresponding endoglucanases would display open active-site clefts [Rouvinen, Bergfors, Teeri, Knowles and Jones (1990) Science 249, 380-386]. Glycoside hydrolase family 6 contains both cellobiohydrolases and endoglucanases. The structure of the catalytic core of the family 6 endoglucanase Cel6B from Humicola insolens has been solved by molecular replacement with the known T. reesei cellobiohydrolase II as the search model. Strangely, at the sequence level, this enzyme exhibits the highest sequence similarity to family 6 cellobiohydrolases and displays just one of the loop deletions traditionally associated with endoglucanases in this family. However, this enzyme shows no activity on crystalline substrates but a high activity on soluble substrates, which is typical of an endoglucanase. The three-dimensional structure reveals that the deletion of just a single loop of the active site, coupled with the resultant conformational change in a second 'cellobiohydrolase-specific' loop, peels open the active-site tunnel to reveal a substrate-binding groove.
CD15-containing glycoconjugates in the central nervous system. (1996)

CD15-containing glycoconjugates have a common trisaccharide residue, 3-fucosyl-N-acetyllactosamine, which can be recognized by a panel of monoclonal antibodies. Immunohistochemical studies revealed a widespread distribution of CD15 in several epithelial non-neural tissues as well as in the CNS. In the mature mammalian brain CD15-containing glycolipids and glycoproteins are constantly present in astrocytes, whereas oligodendrocytes and particular subpopulations of neurons are variably immunostained. CD15 immunoreactive astrocytes are spatially distributed in some brain regions, which points to specialized functions of astroglial subpopulations. The expression of CD15 follows a timely ordered pattern during the development of glial cells and neurons of certain brain areas, such as the human and rat cerebellum and the mouse visual system. During morphogenesis, CD15 may exert either growth-promoting or growth-repulsive activities to guide cell migration. In CNS lesions altered expression patterns of CD15 may occur. For example, in human gliomas the staining intensity for CD15 inversely correlates with the grade of malignancy. In degenerative brain diseases reactive astrocytes may reveal an increased labelling intensity on their cell surface as well as an abnormal cytosolic accumulation of the epitope. The functional significance of CD15 in the CNS is not exactly known yet. The carbohydrate could be involved in cellular adhesion and/or as receptor molecule in signal transduction pathways, as has recently been demonstrated for leukocyte-platelet or leukocyte-endothelial cell interactions.
Thermomechanical properties of the silanized-kenaf/polystyrene composites (2009)

In order to improve the poor interfacial adhesion of the kenaf fiber and polystyrene (PS) in their composite material, the surface of the kenaf fiber was modified using a synthesized polymeric coupling agent to promote adhesion with PS matrix. The dynamic thermo-mechanical properties of the composite composed of modified kenaf fiber and PS were also investigated. The polymeric coupling agent treatment of the kenaf fiber increased the fiber-matrix interaction through a condensation reaction between alkoxysilane and hydroxyl groups of kenaf cellulose. DMA (Dynamic Mechanical Thermal Analysis) results showed that the modified fiber composites have higher E and lower tan than those with untreated fiber indicating that a greater interfacial interaction between the matrix resin and the fiber. It was also found that the storage modulus increases in proportion with the Si/C ratio on the fiber surface.