gebhart/patrepeval huggingface dataset:
Insulin sensitivity regulated by feeding in the conscious unrestrained rat (2002)

Hepatic insulin sensitizing substance (HISS), a putative hormone released from the liver in response to insulin in fed animals, accounts for 50-60% of insulin action. HISS release is regulated by permissive control of the hepatic parasympathetic nerves. The objectives were to develop the rapid insulin sensitivity test (RIST) in conscious rats, and to assess the effects of anesthesia, atropine, feeding, and fasting on insulin action. The RIST index, expressed as milligrams glucose per kilogram body weight required to maintain euglycemia after a 50 mU/kg bolus of insulin, was similar in conscious and anesthetized rats (238.6+/-42.5 vs. 225.3+/-30.4 mg/kg). Atropine produced a 56% inhibition of insulin action in fed rats. After a 24 h fast, full HISS-dependent insulin resistance had developed as shown by a low RIST index that was not reduced further by atropine. Fasting caused a 10.5% decrease in insulin action per hour over six hours. HISS-dependent insulin resistance in 24-h fasted rats was reversed 4 h after re-feeding (90.9+/-12.3 vs. 204.5+/-30.5 mg/kg). We conclude that HISS-dependent and HISS-independent insulin action, as assessed by the RIST, is similar in conscious and pentobarbital-anesthetized rats. Pharmacological blockade of HISS-dependent insulin action and physiological regulation of HISS action by feeding-fasting is confirmed. Re-feeding fasted rats reversed HISS-dependent insulin resistance. Merits of use of the RIST in conscious versus anesthetized rats are discussed.
Determination of methionine enantiomers by HPLC on the cyclofructan chiral stationary phase (2015)

The enantiomeric separation of methionine by high performance liquid chromatography on various cyclofructan type chiral stationary phases in the polar-organic separation mode was studied.
3D-hybridized MAPS and readout ASIC pixel detector for soft x-rays with in-pixel A-to-D conversion (2019)

The continuous advancement of accelerator-based x-ray sources has and will continue to enable new scientific opportunities. To exploit these capabilities a correspondent advancement in detector technology is necessary. FLORA (Fermilab-LCLS CMOS 3D-integRated detector with Autogain) is a large dynamic range hybrid pixel detector with continuous, fast readout rate. The detector comprises a Monolithic Active Pixel Sensor (MAPS), for very low noise and high sensitivity, and a readout ASIC with in pixel Analog-to-Digital converter (ADC), for fast readout. Advanced interconnects will be used to implement the density required for the signals processing. Originally conceived to exploit the high repetition rate operation at LCLS-II with focus on soft X-rays, FLORA can fulfill the needs of the new storage rings and its concept extended to tender and harder X-rays. The current development aims to achieve single photon sensitivity at low energy (250 eV) with a dynamic range of 104 photons per pixel per frame and a readout rate of more than 10 kframes/s.
Metabolic Basis for the Isoleucine, Pantothenate or Methionine Requirement of <i>ilvG</i> Strains of <i>Salmonella typhimurium</i> (1982)

Salmonella typhimurium strain DU501, which was found to be deficient in acetohydroxy acid synthase II (AHAS II) and to possess elevated levels of transaminase B and biosynthetic threonine deaminase, required isoleucine, methionine, or pantothenate for growth. This strain accumulated alpha-ketobutyrate and, to a lesser extent, alpha-aminobutyrate. We found that alpha-ketobutyrate was a competitive substrate for ketopantoate hydroxymethyltransferase, the first enzyme in pantothenate biosynthesis. This competition with the normal substrate, alpha-ketoisovalerate, limited the supply of pantothenate, which resulted in a requirement for methionine. Evidence is presented to support the conclusion that the ambivalent requirement for either pantothenate or methionine is related to a decrease in succinyl coenzyme A, which is produced from pantothenate and which is an obligatory precursor of methionine biosynthesis. The autointoxification by endogenously produced alpha-ketobutyrate could be mimicked in wild-type S. typhimurium by exogenously supplied alpha-ketobutyrate or salicylate, a known inhibitor of pantothenate biosynthesis. The accumulation of alpha-ketobutyrate was initiated by the inability of the residual AHAS activity provided by AHAS I to efficiently remove the alpha-ketobutyrate produced by biosynthetic threonine deaminase. The accumulation of alpha-ketobutyrate was amplified by the action of transaminase B, which decreased the isoleucine pool by catalyzing the formation of alpha-keto-beta-methylvalerate and aminobutyrate from isoleucine and alpha-ketobutyrate; this resulted in release of threonine deaminase from end product inhibition and unbridled production of alpha-ketobutyrate. Isoleucine satisfied the auxotrophic requirement of the AHAS II-deficient strain by curtailing the activity of threonine deaminase. Additional lines of evidence based on genetic and physiological experiments are presented to support the basis for the autointoxification of strain DU501 as well as other nonpolarigenic ilvG mutant strains.
Synthesis of<i>O</i>-Alkyl Carbonochloridothioates (1986)

The preparation of O-alkyl carbonochloridothioates (2) was improved by performing the reaction of thiophosgene with potassium alkoxides in the corresponding alcohol or in tetrahydrofuran at - 65°C for 1 hour. In all cases, the reaction yielded products 2, O,O-dialkyl carbonothioates (4), and dialkyl carbonates (5) in varying distribution.
Novel use of a threadwire saw for high sacral amputation (2005)

The authors describe and demonstrate an innovative modification of the osteotomy procedure required to achieve a supraforaminal high sacral amputation in a patient harboring a large sacral chordoma. Via a combined anterior-posterior approach, three carefully placed threadwire saws were used to create releasing osteotomies through specific portions of the dorsal iliac crests and through the axial midportion of the S-1 vertebral body. The threadwire saws are pulled away from neurovascular and visceral structures, ensuring greater protection. Other advantages include markedly reduced blood loss while performing the osteotomies, a high degree of cutting accuracy, negligible bone loss, and ease and speed of bone cutting.
Calcium Absorption and Achlorhydria (1985)

Defective absorption of calcium has been thought to exist in patients with achlorhydria. I compared absorption of calcium in its carbonate form with that in a pH-adjusted citrate form in a group of 11 fasting patients with achlorhydria and in 9 fasting normal subjects. Fractional calcium absorption was measured by a modified double-isotope procedure with 0.25 g of calcium used as the carrier. Mean calcium absorption (+/- S.D.) in the patients with achlorhydria was 0.452 +/- 0.125 for citrate and 0.042 +/- 0.021 for carbonate (P less than 0.0001). Fractional calcium absorption in the normal subjects was 0.243 +/- 0.049 for citrate and 0.225 +/- 0.108 for carbonate (not significant). Absorption of calcium from carbonate in patients with achlorhydria was significantly lower than in the normal subjects and was lower than absorption from citrate in either group; absorption from citrate in those with achlorhydria was significantly higher than in the normal subjects, as well as higher than absorption from carbonate in either group. Administration of calcium carbonate as part of a normal breakfast resulted in completely normal absorption in the achlorhydric subjects. These results indicate that calcium absorption from carbonate is impaired in achlorhydria under fasting conditions. Since achlorhydria is common in older persons, calcium carbonate may not be the ideal dietary supplement.
Opportunity model for e-commerce recommendation (2013)

Most of existing e-commerce recommender systems aim to recommend the right product to a user, based on whether the user is likely to purchase or like a product. On the other hand, the effectiveness of recommendations also depends on the time of the recommendation. Let us take a user who just purchased a laptop as an example. She may purchase a replacement battery in 2 years (assuming that the laptop's original battery often fails to work around that time) and purchase a new laptop in another 2 years. In this case, it is not a good idea to recommend a new laptop or a replacement battery right after the user purchased the new laptop. It could hurt the user's satisfaction of the recommender system if she receives a potentially right product recommendation at the wrong time. We argue that a system should not only recommend the most relevant item, but also recommend at the right time.
Volumen-selektive MR Spektroskopie am Beispiel Fett/Wasser getrennter T1 -Relaxationszeitbestimmungen (1987)

Article Volumen-selektive MR Spektroskopie am Beispiel Fett/Wasser getrennter T1 -Relaxationszeitbestimmungen was published on January 1, 1987 in the journal Biomedical Engineering / Biomedizinische Technik (volume 32, issue s1).
Overlap in the spectrum of non-specific inflammatory bowel disease--'colitis indeterminate'. (1978)

It is stated that 10-20% of cases of non-specific inflammatory bowel disease cannot be classified. Thirty such cases, designated colitis indeterminate at the time of colectomy, were identified from the pathology files of St. Mark's Hospital. The Histopathological features of the surgical specimens and any available biopsy specimens were studied. In nearly all the cases urgent surgery had been required and the features of incipient or established fulminating disease were present. The pathology of these cases of Crohn's disease and ulcerative colitis overlapped, and differentiating features were scant or unreliable. Accepted criteria of Crohn's disease--namely, fissuring ulceration, transmural inflammation, and a maintained goblet-cell population--were found in cases subsequently proved to be ulcerative colitis. Disease activity greatly affected the evaluation of morphological features. Many of the difficulties were resolved when biopsy material obtained during a quiescent phase was examined. The specimens gave a dynamic perspective of the disease process, often more valuable than the static, non-specific picture of acute disease seen in the surgical specimens. Case of colitis indeterminate form a small distinctive group in the spectrum of inflammatory bowel disease which is characterised by a common pattern of pathology that presents a diagnostic dilemma.
Periodicity transforms (1999)

This paper presents a method of detecting periodicities in data that exploits a series of projections onto "periodic subspaces". The algorithm finds its own set of nonorthogonal basis elements (based on the data), rather than assuming a fixed predetermined basis as in the Fourier, Gabor, and wavelet transforms. A major strength of the approach is that it is linear-in-period rather than linear-in-frequency or linear-in-scale. The algorithm is derived and analyzed, and its output is compared to that of the Fourier transform in a number of examples. One application is the finding and grouping of rhythms in a musical score, another is the separation of periodic waveforms with overlapping spectra, and a third is the finding of patterns in astronomical data. Examples demonstrate both the strengths and weaknesses of the method.
A Novel Cyclopeptide from a Bacterium Associated with the Marine Sponge Ircinia muscarum (2003)

A new cyclotetrapeptide 1, together with three known cyclopeptides were isolated from the exo-cellular extract of Pseudomonas sp. a bacterium associated with the sponge Ircinia muscarum. The structure of 1 was suggested on the basis of spectroscopic analytical data and chemical degradation.
Water with Excess Electric Charge (2011)

Water dropping from a biased metal needle acquires net electric charge that can be stored within a Faraday cup. Positive (negative) water is obtained from a positive (negative) needle, and its charge largely exceeds the Rayleigh limit. Water drops transform into water threads at V < −9.5 kV, even under field strengths much lower than those used in electrospray, electrowetting, or electrospinning experiments. Surface tension of electrified water decreases as the positive or negative charge increases, but its density and viscosity are the same as those of neutral water. Water drops falling in the air through a biased noncontacting metal ring also acquire charge but with opposite sign to the metal potential, in agreement with a recent model for the electrification of insulators or isolated metals, based on charge transfer coupled to water evaporation, adsorption, and desorption.
Syntheses of amorphous and crystalline cupric sulfide nanoparticles and study on the specific activities on different cells (2010)

Copper sulfide amorphous nanoparticles and nanocrystals were prepared successfully by a special process. These CuS nanoparticles could specifically and significantly induce the apoptosis and inhibit the proliferation of human cancer cells rather than normal cells. Moreover, the biological activities of these nanoparticles are related to their polymorphs.
Separation Control Using Plasma Actuators: Dynamic Stall Vortex Control on Oscillating Airfoil (2006)

A plasma actuator was used to control leading-edge flow separation and dynamic stall vortex on a periodically oscillated NACA 0015 airfoil. The effectiveness of the actuator was documented through phase-conditioned surface pressure measurements and smoke flow visualization records. The airfoil was driven in a periodic cycle corresponding to α = 15 deg+10deg sinwt. The results presented here are for a reduced frequency of k = ωc/2U ∞ = 0.08. Three cases of control with the plasma actuator were investigated: open-loop control with steady plasma actuation, open-loop control with unsteady plasma actuation, and closed-loop control with steady plasma actuation. For closed-loop control, the actuator was activated in selected portions of the oscillatory cycle based on angle-of-attack feedback. All of the cases investigated exhibited an increase in cycle-integrated lift with improvements in the lift-cycle hysteresis. In two cases, the pitch-moment stall angle was delayed and in one of these, the adverse negative moment peak was significantly reduced.
Incorporating Platelet-Rich Plasma into Electrospun Scaffolds for Tissue Engineering Applications (2011)

Platelet-rich plasma (PRP) therapy has seen a recent spike in clinical interest due to the potential that the highly concentrated platelet solutions hold for stimulating tissue repair and regeneration. The aim of this study was to incorporate PRP into a number of electrospun materials to determine how growth factors are eluted from the structures, and what effect the presence of these factors has on enhancing electrospun scaffold bioactivity. PRP underwent a freeze-thaw-freeze process to lyse platelets, followed by lyophilization to create a powdered preparation rich in growth factors (PRGF), which was subsequently added to the electrospinning process. Release of protein from scaffolds over time was quantified, along with the quantification of human macrophage and adipose-derived stem cell (ADSC) chemotaxis and proliferation. Protein assays demonstrated a sustained release of protein from PRGF-containing scaffolds at up to 35 days in culture. Scaffold bioactivity was enhanced as ADSCs demonstrated increased proliferation in the presence of PRGF, whereas macrophages demonstrated increased chemotaxis to PRGF. In conclusion, the work performed in this study demonstrated that the incorporation of PRGF into electrospun structures has a significant positive influence on the bioactivity of the scaffolds, and may prove beneficial in a number of tissue engineering applications.
Human Toll-like receptor 4 responses to<i>P. gingivalis</i>are regulated by lipid A 1- and 4′-phosphatase activities (2009)

Signal transduction following binding of lipopolysaccharide (LPS) to Toll-like receptor 4 (TLR4) is an essential aspect of host innate immune responses to infection by Gram-negative pathogens. Here, we describe a novel molecular mechanism used by a prevalent human bacterial pathogen to evade and subvert the human innate immune system. We show that the oral pathogen, Porphyromonas gingivalis, uses endogenous lipid A 1- and 4'-phosphatase activities to modify its LPS, creating immunologically silent, non-phosphorylated lipid A. This unique lipid A provides a highly effective mechanism employed by this bacterium to evade TLR4 sensing and to resist killing by cationic antimicrobial peptides. In addition, lipid A 1-phosphatase activity is suppressed by haemin, an important nutrient in the oral cavity. Specifically, P. gingivalis grown in the presence of high haemin produces lipid A that acts as a potent TLR4 antagonist. These results suggest that haemin-dependent regulation of lipid A 1-dephosphorylation can shift P. gingivalis lipid A activity from TLR4 evasive to TLR4 suppressive, potentially altering critical interactions between this bacterium, the local microbial community and the host innate immune system.
A-Active Trisaccharides Isolated from A1 and A2 Blood-Group-Specific Glycoproteins (1981)

Blood-group-specific glycoproteins obtained from ovarian cyst fluids of A1 and A2 persons were degraded with NaOH/NaBH4. The oligosaccharides released were de-N-acetylated with Ba(OH)2 and then hydrolysed with dilute H2SO4. The products were fractionated on columns of ion-exchange resin and the components isolated were re-N-acetylated with 14C-labelled acetic anhydride; further purification was effected by paper chromatography. The following trisaccharides: type 1, GalNAc(alpha 1-3)Gal(beta 1-3)GlcNAc; type 2, GalNAc(alpha 1-3)-Gal(beta 1-4)GlcNAc; type 3 (reduced), GalNAc(alpha 1-3)Gal (beta 1-3)GalNAcOH (where Gal is galactose; GalNAc is N-acetylgalactosamine, GlcNAc is N-acetylglucosamine and GalNAcOH is N-acetylgalactosaminitol) were isolated and characterised from both the A1 and A2 materials. The type 3 (reduced) trisaccharide has not previously been obtained from human glycoproteins. Chromatographic evidence indicated that the three trisaccharide structures were also present in other A1, A2, A1B and A2B ovarian cyst glycoproteins and in A1 and A2 salivary glycoproteins. These findings are not indicative of structural differences between the A determinants of A1 and A2 glycoproteins.
A crystal structure with features of an antiparallel α‐pleated sheet (1994)

A single-crystal x-ray diffraction analysis of Boc-L-Ala-D-aIle-L-Ile-OMe has been carried out. The analysis has shown (a) that the tripeptide molecules have in part an alpha-extended conformation, the torsion angles of the L-Ala and D-aIle residues being psi 1 = -75.1 degrees and psi 1 = -25.8 degrees and psi 2 = 67.3 degrees and psi 2 = 44.1 degrees, respectively, and (b) that the molecules are organized in rippled planes where they occur in relative antiparallel orientation linked together side by side by H bonds. This molecular organization of the tripeptide corresponds closely to that of an antiparallel alpha-pleated sheet, and likely constitutes the first example of a structure of this kind for which a characterization at the atomic level has been achieved. A molecular dynamics study has shown that the molecular conformation of the tripeptide in the crystalline state is determined primarily by intermolecular interactions.
Regular fabric design with ambipolar CNTFETs for FPGA and structured ASIC applications (2010)

In this paper, we propose for the first time the application of ambipolar CNTFETs with in-field controllable polarities to design regular fabrics with static logic. We exploit the high expressive power provided by complementary static logic built with ambipolar CNTFETs to design compact and efficient configurable gates. After evaluating a polarity-aware logic design for the configurable gates, we selected a number of gates with an And-Or-Inverter structure and produced a first comparison with existent medium-grained logic blocks, like the Actel ACT1 and 4-input LUTs. Preliminary evaluation of our gates indicates improvements of around 47% over the ACT1 and of about 18× with respect to 4-input LUTs in terms of area×normalized delay.
Evaporation Suppression by Monolayers on Aqueous Saline Solutions (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEvaporation Suppression by Monolayers on Aqueous Saline SolutionsF. A. Cheeves, R. G. Dressler, and W. C. McGavockCite this: Ind. Eng. Chem. Prod. Res. Dev. 1965, 4, 3, 206–209Publication Date (Print):September 1, 1965Publication History Published online1 May 2002Published inissue 1 September 1965https://pubs.acs.org/doi/10.1021/i360015a014https://doi.org/10.1021/i360015a014research-articleACS PublicationsRequest reuse permissionsArticle Views44Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Manipulation of the Growth of Gold and Silver Nanomaterials on Glass by Seeding Approach (2006)

This paper describes the growth of gold and silver nanomaterials from their corresponding colloidal seeds on glass substrates. The glass substrates were treated with 3-mercaptopropyltrimethoxysilane (MPTMS) and then with gold or silver nanoparticle seeds (AuNPSs or AgNPSs) at different concentrations. After separately immersing the thus-prepared MPTMS-AuNPS and MPTMS-AgNPS glass substrates in aqueous solutions containing cetyltrimethylammonium bromide, ascorbic acid, and gold or silver ions, we obtained Au and Ag nanomaterials of different sizes and shapes, which we characterized through scanning electron microscopy (SEM) and dark-field microscopy (DFM). At 0.001x concentrations AuNPSs and AgNPSs (i.e., 1000-fold-diluted solutions of the as-prepared samples), Au and Ag nanomaterials having 1.36 and 5.21 mum lengths and aspect ratios of 11 and 24 were prepared in yields of 27% and 54%, respectively. Scattering spectra of the thus-prepared single AuNRs and AgNRs revealed that the uniformity in the shape of the AuNRs was greater than that of the AgNRs. In addition, we demonstrate the preparation (using a laboratory-made synthesis system) and characterization (through DFM measurements) of Au nanomaterials, including AuNRs, from five AuNPS solutions of different concentrations on a single glass substrate.
Robustness and Reproducibility of Flow Territories Defined by Planning-Free Vessel-Encoded Pseudocontinuous Arterial Spin-Labeling (2011)

Flow-territory mapping by MR imaging ASL noninvasively provides a unique insight into the distribution of cerebral perfusion. The introduction of planning-free vessel-encoded pCASL made flow-territory mapping feasible for clinical use, though lack of individual planning could impede reproducibility of this technique. We assessed the reproducibility of planning-free vessel-encoded pCASL in patients and controls. Results indicated that planning-free vessel-encoded pCASL is a reproducible method that could assist in clinical decision-making.