gebhart/patrepeval huggingface dataset:
Do Patients with Severe Asthma Run an Increased Risk from Ischaemic Heart Disease? (1996)

These findings suggest that subjects with severe asthma, especially women, have an increased mortality from ischaemic heart disease. The results may reflect confounding, mainly smoking and physical inactivity. Other explanations may be side effects of the antiasthmatic drugs or an effect of longstanding airway obstruction.
Predicting protein–protein interactions based only on sequences information (2007)

Protein-protein interactions (PPIs) are central to most biological processes. Although efforts have been devoted to the development of methodology for predicting PPIs and protein interaction networks, the application of most existing methods is limited because they need information about protein homology or the interaction marks of the protein partners. In the present work, we propose a method for PPI prediction using only the information of protein sequences. This method was developed based on a learning algorithm-support vector machine combined with a kernel function and a conjoint triad feature for describing amino acids. More than 16,000 diverse PPI pairs were used to construct the universal model. The prediction ability of our approach is better than that of other sequence-based PPI prediction methods because it is able to predict PPI networks. Different types of PPI networks have been effectively mapped with our method, suggesting that, even with only sequence information, this method could be applied to the exploration of networks for any newly discovered protein with unknown biological relativity. In addition, such supplementary experimental information can enhance the prediction ability of the method.
Ovarian cancers overexpress the antimicrobial protein hCAP‐18 and its derivative LL‐37 increases ovarian cancer cell proliferation and invasion (2007)

The role of the pro-inflammatory peptide, LL-37, and its pro-form, human cationic antimicrobial protein 18 (hCAP-18), in cancer development and progression is poorly understood. In damaged and inflamed tissue, LL-37 functions as a chemoattractant, mitogen and pro-angiogenic factor suggesting that the peptide may potentiate tumor progression. The aim of this study was to characterize the distribution of hCAP-18/LL-37 in normal and cancerous ovarian tissue and to examine the effects of LL-37 on ovarian cancer cells. Expression of hCAP-18/LL-37 was localized to immune and granulosa cells of normal ovarian tissue. By contrast, ovarian tumors displayed significantly higher levels of hCAP-18/LL-37 where expression was observed in tumor and stromal cells. Protein expression was statistically compared to the degree of immune cell infiltration and microvessel density in epithelial-derived ovarian tumors and a significant correlation was observed for both. It was demonstrated that ovarian tumor tissue lysates and ovarian cancer cell lines express hCAP-18/LL-37. Treatment of ovarian cancer cell lines with recombinant LL-37 stimulated proliferation, chemotaxis, invasion and matrix metalloproteinase expression. These data demonstrate for the first time that hCAP-18/LL-37 is significantly overexpressed in ovarian tumors and suggest LL-37 may contribute to ovarian tumorigenesis through direct stimulation of tumor cells, initiation of angiogenesis and recruitment of immune cells. These data provide further evidence of the existing relationship between pro-inflammatory molecules and ovarian cancer progression.
Time‐resolved <i>in vivo</i> luminescence dosimetry for online error detection in pulsed dose‐rate brachytherapy (2009)

In vivo fiber-coupled RL/OSL dosimetry based on detectors placed in standard brachytherapy needles was demonstrated. The time-resolved dose-rate measurements were found to provide a good way to visualize the progression and stability of PDR brachytherapy dose delivery, and time-resolved dose-rate measurements provided an increased sensitivity for detection of dose-delivery errors compared with time-integrated dosimetry.
RAPID COMMUNICATION: Blockade of nociceptin/orphanin FQ transmission in rat substantia nigra reverses haloperidol‐induced akinesia and normalizes nigral glutamate release (2004)

We recently showed that pharmacological blockade of nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptors located in the substantia nigra stimulates the nigrostriatal dopaminergic pathway and motor behavior (Marti et al. J. Neurosci. 2004, 24, 6659-6666). To investigate whether such motor-stimulating action was dependent on functional dopaminergic transmission, the selective NOP receptor peptide antagonist [Nphe1,Arg14,Lys15]N/OFQ-NH2 (UFP-101) was microinjected into the substantia nigra reticulata of rats made cataleptic by systemic haloperidol administration. UFP-101 reduced haloperidol-induced akinesia as measured by immobility time in the bar test. UFP-101 also induced contralateral turning in cataleptic rats. To investigate the mechanisms involved in the anti-akinetic action of UFP-101, nigral glutamate release was monitored by microdialysis technique. The anti-akinetic action of UFP-101 correlated with normalization of nigral glutamate release, previously elevated by haloperidol injection. We conclude that endogenous N/OFQ in the substantia nigra sustains akinesia generated by impaired DA transmission and subthalamic nucleus overactivation. NOP receptor antagonists may be beneficial in the symptomatic therapy of parkinsonism, via normalization of subthalamonigral glutamatergic transmission.
P‐18: Highly Stable a‐Si TFT Gate Driver with Simple Logic Circuit (2008)

Abstract A novel integrated gate driver with a simple logic circuit (SLC) using 5 a‐Si TFTs has been developed. The noise voltage owing to clock coupling is eliminated effectively with an overlapped clock controlled transistor. The SLC gate driver, successfully integrated in 14.1‐in. XGA TFT‐LCD's, shows marked stability despite the extremely simple structure.
Optical clock distribution using a mode-locked semiconductor laser diode system (1991)

An experiment in which a high-power mode-locked femtosecond semiconductor laser system was used as a source of extremely low jitter intense optical pulses in the distribution of a clock to 1024 ports via optical fibers is described. The total accumulated dynamic clock jitter between any two ports, which contains both correlated and uncorrelated sources, was measured to be less than 12 ps. This laser system produced a train of 460-fs optical pulses with over 70 W of peak power at 302 MHz. These results represent the largest fanout with the minimum timing jitter for an optically distributed clocking network.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The effect of selegiline in the treatment of people with Alzheimer's disease: a meta‐analysis of published trials (2002)

Although there was some evidence of improvement with selegiline in the short term in cognition and activities of daily living, the magnitude of the effect did not reach clinical importance. There was no evidence of long term effects.
Intrathecal Interferon Reduces Exacerbations of Multiple Sclerosis (1981)

Ten patients with multiple sclerosis who were treated with human fibroblast interferon (IFN-B) for 6 months showed a significant reduction in their exacerbation rates compared with their rates before treatment (P < .01). The IFN-B was administered intrathecally by serial lumbar punctures. There was no significant change in the exacerbation rates of ten multiple sclerosis control patients before and during the period of observation. The IFN-B recipients have now been on the study a mean of 1.5 years, the controls, 1.2 years. The clinical condition of five of the IFN-B recipients and one of the control patients has improved, whereas the condition of five of the controls and one of the IFN-B recipients has deteriorated (P < .036). These findings warrant cautious optimism about the efficacy of intrathecal IFN-B in altering the course of multiple sclerosis and support concepts of a viral or dysimmune etiology of the disease.
<i><b><i>π</i></b></i>‐Conjugated Oligothiophene‐Based Polycatenar Liquid Crystals: Self‐Organization and Photoconductive, Luminescent, and Redox Properties (2008)

Abstract A series of liquid‐crystalline (LC) π‐ ‐conjugated oligothiophenes bearing three or two alkoxy chains at their extremities has been designed and synthesized. These polycatenar oligothiophenes form various LC nanostructures including smectic, columnar, and micellar cubic phases. These properties depend on the number and length of the terminal alkoxy chains. The hole mobilities for the oligothiophenes have been measured. The layered smectic and columnar structures are capable of transporting holes, leading to mobilities of up to 0.01 cm 2 V −1 s −1 . The columnar LC assemblies have also been explored to produce linearly polarized light‐emission. Fine red polarized fluorescence is observed from a uniaxially aligned film of the oligothiophenes. The redox properties of the oligothiophenes both in solutions and in films have been examined. The oligothiophenes exhibit electrochromism upon applying an oxidative potential. The present design strategy is useful for fabricating a variety of functional electro‐active molecular assemblies.
On the architecture of the cdma2000/spl reg/ variable-rate multimode wideband (VMR-WB) speech coding standard (2004)

The description and design of the source-controlled variable-rate multimode wideband (VMR-WB) codec recently selected by the 3/sup rd/ Generation Partnership Project 2 (3GPP2) for the cdma2000/spl reg/ system in Rate-Set II are presented. The paper gives an overview of the codec and the methodologies that enable high quality wideband coding at average data rates ranging from TIA/EIA/IS-733 ADR (average data rate) to that of TIA/EIA/IS-127. The codec has three modes of operation at different average data rates and a fourth mode that is interoperable with 3GPP/AMR-WB (ITU-T G.722.2). Despite the interoperability constraint, the codec is capable of meeting the aggressive performance requirements through the use of novel techniques such as noise suppression, efficient signal classification, new coding types optimized for stable voiced and unvoiced frames, novel post-processing technique for periodicity enhancement in the lower frequency band, and improved frame erasure concealment mechanisms.
The <i>pag</i> gene product, a physiological inhibitor of c‐<i>abl</i> tyrosine kinase, is overexpressed in cells entering S phase and by contact with agents inducing oxidative stress (1998)

The human pag gene product is an inhibitor of the c-abl tyrosine kinase and belongs to a new family of proteins. We show here that higher levels of pag gene expression are observed following induction of proliferation and contact with compounds inducing oxidative stress such as diethyl maleate and sodium arsenate. A weaker overexpression is seen in a macrophage cell line using hydrogen peroxide or menadione as inducers. Pag gene expression increases in synchronized cells entering the S phase. This raises the possibility that elevated levels of pag counteract the cytostatic activity of abl. Treatment of growth arrested cells with diethyl maleate and sodium arsenate induces pag gene overexpression, independently of cell proliferation. Thus, enhanced pag gene expression occurs in two cellular events: proliferation and response to oxidative stress.
Social-Aware UAV-Assisted Mobile Crowd Sensing in Stochastic and Dynamic Environments for Disaster Relief Networks (2019)

In this paper, we consider a social-aware unmanned aerial vehicle (UAV) assisted mobile crowd sensing (MCS) system for disaster relief networks, and investigate how to recruit suitable UAVs to perform sensing tasks in stochastic and dynamic environments (both UAVs and tasks arrive stochastically). We formulate the task assignment problem into a dynamic matching problem, and propose a multiple-waitlist based task assignment (MWTA) algorithm to find the stable matching in time-varying environment. We prove that MWTA can achieve the dynamic stability containing the strategy-proofness, efficiency, and envy-freeness. Simulation results demonstrate the performance improvement of our proposed scheme compared with the traditional matching algorithm applied to deterministic matching model in stochastic setting.
A New Approach to Percutaneous Subclavian Venipuncture to Avoid Lead Fracture or Central Venous Catheter Occlusion (1993)

Pacemaker and defibrillator leads and central venous catheters placed by commonly recommended techniques have been found to pass through the subclavius muscle, the costocoracoid ligament, or the costoclavicular ligament before entering veins medial to the first rib. Entrapment by these soft tissues subjects leads and catheters to stresses imposed by movements of the ipsilateral upper extremity. Accordingly, a new approach has been developed that introduces the lead or catheter into the subclavian vein near the lateral border of the first rib. This placement avoids soft tissue entrapment and may extend the longevity of leads and catheters.
Requirement for a <i>beta</i>  2-microglobulin-associated Fc receptor for acquisition of maternal IgG by fetal and neonatal mice. (1995)

There is considerable evidence to suggest that an FcR similar in structure to class I MHC Ags, neonatal Fc receptor (FcRn), transports IgG across the intestinal epithelium of suckling mice. However, this has not previously been shown definitively, nor has it been shown whether FcRn is the only, or even the major, IgG transporter in the neonatal mouse gut. We report here that neonatal mice homozygous for a targeted disruption of the beta 2microglobulin (beta 2m) gene, which encodes one subunit of FcRn, had reduced FcRn alpha-chain at the lumenal plasma membrane of intestinal cells. These mice had strikingly lower serum IgG levels during the first month after birth than littermates that possessed functional FcRn. Furthermore, we found by fostering mice on mothers with a different IgG allotype that all of the IgG in sera of beta 2m-/- mice was endogenous, and that none was obtained from milk. We conclude that FcRn is the only transporter of IgG from mother to young in the mouse. The onset of IgG synthesis in mice that received no milk IgG lagged behind that in siblings with normal IgG transport, suggesting that maternal IgG stimulates Ab production in the neonate. We noted no difference between the IgG concentrations in the milk of beta 2m-/- and beta 2m+/- mice, indicating that FcRn is not involved in the secretion of IgG into milk.
Enhancement of radiation response by roscovitine in human breast carcinoma in vitro and in vivo. (2003)

Frequent deregulation of cyclin-dependent kinase (CDK) activation associated with loss of cell cycle control was found in most of human cancers. A recent development of a new class of antineoplasic agents targeting the cell cycle emerged as a small molecule CDK inhibitor, roscovitine, which presents potential antiproliferative and antitumoral effects in human tumors. Additional studies reported that roscovitine combined with cytotoxic agents can cooperate with DNA damage to activate p53 protein. However, little is known about the biological effect of roscovitine combined with ionizing radiation (IR) in human carcinoma, and no studies were reported thus far in p53 mutated carcinoma. In the breast cancer cell line MDA-MB 231, which lacks a functional p53 protein, we found a strong radiosensitization effect of roscovitine in vitro by clonogenic survival assay and in vivo in MDA-MB 231 xenograft model. Using Pulse Field Gel Electrophoresis, a strong impairment in DNA-double-strand break rejoining was observed after roscovitine and IR treatment as compared with IR alone. Cell cycle analysis showed a G(2) delay and no increase in radiation-induced apoptosis in the cells treated with IR or roscovitine and IR. On the other hand, we found a significant induction in micronuclei frequency after roscovitine and IR treatment as compared with IR alone. This effect was also observed in BALB murine cells in contrast to SCID murine cells, which are deficient in DNA-PKcs, suggesting a possible DNA-double-strand break repair defect in the nonhomologous end joining pathways. In MDA-MB 231 cells, the radiosensitization effect of roscovitine was associated with an inhibition of the DNA-dependent protein kinase activity caused by a marked decrease in Ku-DNA binding by using the electrophoretic mobility shift assay. In conclusion, we found a novel effect on DNA repair of the CDK inhibitor roscovitine, which acts as a radiosensitizer in vitro and in vivo in breast cancer cells lacking a functional p53.
High Extraction Magnetic Filtration of Kaolin Clay (1976)

Abstract A new magnetic separation technique combines high magnetic fields, extreme gradients, and controlled retention time to separate feebly magnetic mineral contaminants from kaolin. Extraction of pyrite, siderite, hematite, iron stained anatase, and mica by magnetic filtration of kaolin significantly upgrades brightness of many sub-marginal deposits and reduces consumption of reagents in processing.
INTENSITY DISCRIMINATION IN THE HUMAN EYE (1936)

New measurements of the brightness difference sensibility of the eye corroborate the data of previous workers which show that ΔI/I decreases as I increases. Contrary to previous report, ΔI/I does not normally increase again at high intensities, but instead decreases steadily, approaching a finite limiting value, which depends on the area of the test-field and on the brightness of the surrounding field. On a logarithmic plot, the data of ΔI/I against I for test-fields below 2° are continuous, whereas those for test-fields above 2° show a sharp discontinuity in the region of intensity in which ΔI/I decreases rapidly. This discontinuity is shown to divide the data into predominantly rod function at low intensities, and predominantly cone function at high intensities. Fields below 2° give higher values of ΔI/I at all intensities, when compared with larger fields. Fields greater than one or two degrees differ from one another principally on the low intensity side of the break. Changes in area above this limit are therefore mainly effective by changing the number of rods concerned. This is confirmed by experiments controlling the relative numbers of rods and cones with lights of different wavelength and with different retinal locations. At high intensities ΔI/I is extremely sensitive to changes in brightness of surrounding visual fields, except for large test-fields which effectually furnish their own surrounds. This sensitivity is especially marked for fields of less than half a degree in diameter. Although the effect is most conspicuous for high intensities, the surround brightness seems to affect the relation between variables as a whole, except in very small fields where absence of a surround of adequate brightness results in the distortion of the theoretical relation otherwise found. The theoretical relationship for intensity discrimination derived by Hecht is shown to fit practically all of the data. Changes in experimental variables such as retinal image area, wavelength, fixation, and criterion may be described as affecting the numerical quantities of this relationship.
Empirical Margin Distributions and Bounding the Generalization Error of Combined Classifiers (2002)

We prove new probabilistic upper bounds on generalization error of complex classifiers that are combinations of simple classifiers. Such combinations could be implemented by neural networks or by voting methods of combining the classifiers, such as boosting and bagging. The bounds are in terms of the empirical distribution of the margin of the combined classifier. They are based on the methods of the theory of Gaussian and empirical processes (comparison inequalities, symmetrization method, concentration inequalities) and they improve previous results of Bartlett (1998) on bounding the generalization error of neural networks in terms of $\ell_1$-norms of the weights of neurons and of Schapire, Freund, Bartlett and Lee (1998) on bounding the generalization error of boosting. We also obtain rates of convergence in Lévy distance of empirical margin distribution to the true margin distribution uniformly over the classes of classifiers and prove the optimality of these rates.
A framework for dynamic analysis dependency in component-based system (2010)

Dependency analysis is a useful technique that has many applications in software engineering activities. In this paper, we present a new dynamic dependency analysis framework for COM. The framework utilizes probe techniques to create proxy components. Dependency analysis algorithm is proposed to extract dependencies in component-based system. The experiment results show that the dependency analysis framework can extract dependencies among components dynamically and accurately.
Biochemical composition and nutritive value of krill (<i>Euphausia superba</i> Dana) (1970)

Abstract Frozen samples of Antarctic krill ( Euphausia superba Dana) were found to contain 71·4% moisture, and on a dry matter basis 24·6% lipid, 49% protein (N × 6·25), 2·5% chitin, and 9·8% ash. Fatty acids from the crude lipid fraction were made up of 43·8% saturated, 32·8% mono‐unsaturated, and 23·4% polyunsaturated types. Krill protein concentrate prepared as a light, free‐flowing powder by isopropanol extraction of krill contained 74·3% crude protein, 15·4% ash, 6% chitin and 0·3% lipid, and was rich in lysine, arginine, tryptophan, and threonine. The protein efficiency ratio of this concentrate was found to be the same as that of casein. The significance of these results in relation to those obtained for other fish protein concentrates is discussed.
Dumbbell Shape Defected Ground Structure High Gain Antenna for Dual Band Application (2018)

Based on the traditional antennas with DGS, we have compared three similar circular DGS designs to find a better one in thispaper. Meanwhile, four T-shaped slots impedance transformer is used on the patch as a dual-band recouple to achieve dual-band technology. With the simulation, it is found that the antenna with three circular defects on the ground plane has better performances than the other two antennas. It has two resonant frequencies at 7.5GHz and 8.9GHz. The relative bandwidth is 3.33% and 3.94%, and the corresponding gain value is 9.45 dBi and 13.37dBi at two different resonance frequencies. Further, we obtained a higher gain, lower return loss and dual-band characteristics which can be used in the satellite communications.
Virtual Simulation of Technical Interviews (2017)

Interview provides an opportunity for an individual to pursue in his/her dream job. Interview, if cleared, gives an opportunity to get employed and leads to employment, removing an individual from a state of unemployment to employment, or leading an individual switch to a new position or company. In any means, without interview no one can get a job. If an interview can provide so many benefits and can open new doors of avenue, then preparing for it also becomes very important. However, preparing for the interview is no piecemeal. A lot of hard work is required to clear an interview. If the company or the job is an individual's dream, to achieve it in a right way becomes very crucial. In this paper, the authors are presenting a system, which can be helpful for individual to prepare for interviews.
Automatic lyrics-to-audio alignment in classical Turkish music (2014)

Comunicació presentada al Fourth International Workshop on Folk Music Analysis (FMA2014), celebrat els dies 12 i 13 de juny de 2014 a Istanbul, Turquia.