gebhart/patrepeval huggingface dataset:
From Sirtuin Biology to Human Diseases: An Update (2012)

Originally rising to notoriety for their role in the regulation of aging, sirtuins are a family of NAD(+)-dependent enzymes that have been connected to a steadily growing set of biological processes. In addition to regulating aging, sirtuins play key roles in the maintenance of organismal metabolic homeostasis. These enzymes also have primarily protective functions in the development of many age-related diseases, including cancer, neurodegeneration, and cardiovascular disease. In this minireview, we provide an update on the known roles for each of the seven mammalian sirtuins in these areas.
Supportive care in pediatric oncology (1993)

Cure of children with cancer is occurring in ever increasing numbers. Research in supportive care areas such as pain management, emesis control, and infection prevention and treatment, has contributed not only to improved survival, but a better quality of life for children undergoing cancer treatment. Additionally, long-term follow-up of childhood cancer survivors is yielding information that will decrease the morbidity of future treatment regimens.
Fractionation of Cellulose Acetate (1952)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFractionation of Cellulose AcetateA. J. Rosenthal and B. B. WhiteCite this: Ind. Eng. Chem. 1952, 44, 11, 2693–2696Publication Date (Print):November 1, 1952Publication History Published online1 May 2002Published inissue 1 November 1952https://pubs.acs.org/doi/10.1021/ie50515a055https://doi.org/10.1021/ie50515a055research-articleACS PublicationsRequest reuse permissionsArticle Views170Altmetric-Citations56LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
A Mitotic Lamin B Matrix Induced by RanGTP Required for Spindle Assembly (2006)

Mitotic spindle morphogenesis is a series of highly coordinated movements that lead to chromosome segregation and cytokinesis. We report that the intermediate filament protein lamin B, a component of the interphase nuclear lamina, functions in spindle assembly. Lamin B assembled into a matrix-like network in mitosis through a process that depended on the presence of the guanosine triphosphate-bound form of the small guanosine triphosphatase Ran. Depletion of lamin B resulted in defects in spindle assembly. Dominant negative mutant lamin B proteins that disrupt lamin B assembly in interphase nuclei also disrupted spindle assembly in mitosis. Furthermore, lamin B was essential for the formation of the mitotic matrix that tethers a number of spindle assembly factors. We propose that lamin B is a structural component of the long-sought-after spindle matrix that promotes microtubule assembly and organization in mitosis.
Elicitor-Induced l-Tyrosine Decarboxylase from Plant Cell Suspension Cultures (1988)

Properties of purified l-tyrosine decarboxylase (EC 4.1.1.25) from elicitor-induced cell suspension cultures of Eschscholtzia californica Cham. and Thalictrum rugosum Ait. are described. l-Tyrosine decarboxylase is a dimeric enzyme with a molecular weight of 112,600 +/- 600 daltons. The isoelectric point was estimated to be at pH 5.2 and pH 5.4 for the enzyme from E. californica and T. rugosum, respectively. The purified enzymes were stabilized in the presence of pyridoxal-5-phosphate. Optimum pH for the enzyme from both plants was found to be 8.4. Enzyme activity was dependent on exogeneously supplied pyridoxal-5-phosphate. The enzyme decarboxylated l-tyrosine and l-beta-3,4-dihydroxyphenylalanine but was inactive toward l-phenylalanine and l-tryptophan. Apparent K(m) values of Eschscholtzia- and Thalictrum-decarboxylase for l-tyrosine were 0.25 +/- 0.03 and 0.27 +/- 0.04 millimolar, respectively. Similar affinities were found for l-3,4-dihydroxyphenylalanine. Eschscholtzial-tyrosine decarboxylase was strongly inhibited by the phenylalanine analogue l-alpha-aminooxy-beta-phenylpropionate and largely unaffected by d,l-alpha-monofluoromethyl-3,4-dihydroxyphenylalanine and alpha-difluoromethyltyrosine.
Synthesis and polymerization of pentaerythritol monoacrylate and methacrylate and their bicyclic ortho esters (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and polymerization of pentaerythritol monoacrylate and methacrylate and their bicyclic ortho estersA. Buyle Padias and H. K. Hall Jr.Cite this: Macromolecules 1982, 15, 2, 217–223Publication Date (Print):March 1, 1982Publication History Published online1 May 2002Published inissue 1 March 1982https://pubs.acs.org/doi/10.1021/ma00230a001https://doi.org/10.1021/ma00230a001research-articleACS PublicationsRequest reuse permissionsArticle Views755Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Brain Glucose Metabolism During Non—Rapid Eye Movement Sleep in Major Depression (1996)

These findings provide further support for the hyperarousal hypothesis of some types of major depressive disorder. Abnormal patterns of cerebral metabolism during non-REM sleep in depressed patients confirmed earlier waking findings of decreased relative frontal and abnormal limbic metabolic activity and striatal metabolism in association with posterior cortical increases.
Spin Selectivity in Electron Transmission Through Self-Assembled Monolayers of Double-Stranded DNA (2011)

Photoelectrons emitted from a DNA-covered gold surface can have an unbalanced spin population of up to 60%.
Monoclonal Antibodies That Bind to Common Epitopes on the Dengue Virus Type 2 Nonstructural-1 and Envelope Glycoproteins Display Weak Neutralizing Activity and Differentiated Responses to Virulent Strains: Implications for Pathogenesis and Vaccines (2007)

The abilities of monoclonal antibodies (MAbs) that bind to defined sequential epitopes on the dengue virus (DENV) nonstructural-1 (NS1) glycoproteins to cross-react with epitopes on the DENV envelope (E) glycoproteins were investigated. In this study, some of these MAbs cross-reacted with the DENV type 2 (DENV-2) E glycoprotein and with synthetic peptides representing X-ray crystallographically confirmed surface-exposed regions on this glycoprotein. MAb 1G5.3 cross-reacted with the flavivirus-conserved 101-WGNGCGLFG-109 fusion sequence, the 273-SSGNL-277 DENV-2 hinge region sequence, and the 156-GKHGKEIKIT-165 sequence of virulent DENV-2 strains. MAb 1G5.4-A1-C3 cross-reacted with the 67-NTTTESRCPT-76 and 156-GKHGKEIKIT-165 sequences of virulent DENV-2 strains, the 338-EIMDLDNRHV-347 sequence from a highly virulent DENV-2 (M2) strain, and two epitopes on a virulent DENV-3 strain (288-KMDKLELKG-296 and 323-RVEYRGEDAP-332), which all contained target ELK/KLE-type motifs (underlined). These MAbs showed reduced cross-reactions with the corresponding sequences from weakly pathogenic strains of all four DENV serotypes and had either no (MAb 1G5.4-A1-C3) or weak (MAb 1G5.3) neutralizing activity against them. MAb 1G5.3 more strongly neutralized DENV-2 strains with higher pathogenic capacities, while MAb 1G5.4-A1-C3 showed increasing neutralizing titers against the virulent DENV-3 strain and the moderately virulent and highly virulent (M2) DENV-2 strains. These cross-reactions with the E glycoprotein accord with the observation that MAb 1G5.3 caused dramatic and lethal antibody-enhanced replication (AER) of a DENV-2 strain in vivo. Together with in vivo AER studies of these DENV strains using MAb 1G5.4-A1-C3, these results may account for the increased pathogenic capacities of such strains, which is likely to have important implications for pathogenesis and vaccines.
Electron Paramagnetic Resonance Studies of Transient Free Radicals Produced by Pulse Radiolysis (1968)

Electron paramagnetic studies have been conducted on the transient free radicals produced by pulse radiolysis in liquids. The instrument design permitted observation of radical lifetimes ≥2 − 3 μsec and corresponding rate constants ≤1010M − 1·sec − 1. The effect of radical scavengers such as sulfur-containing compounds or oxygen on the transient behavior of the cyclopentyl and cyclohexyl radical were studied and the pertinent rate constants determined for the reaction. Recombination rate constants for cycloalkyl as well as alkyl- and cycloalkyl-peroxy radicals were compared along with the activation energy for representative species.
1,4,7-Triazacyclononane-N,N',N''-triacetate (TCTA), a new hexadentate ligand for divalent and trivalent metal ions. Crystal structures of [CrIII(TCTA)], [FeIII(TCTA)], and Na[CuII(TCTA)].bul.2NaBr.bul.8H2O (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT1,4,7-Triazacyclononane-N,N',N''-triacetate (TCTA), a new hexadentate ligand for divalent and trivalent metal ions. Crystal structures of [CrIII(TCTA)], [FeIII(TCTA)], and Na[CuII(TCTA)].bul.2NaBr.bul.8H2OKarl Wieghardt, Ursula Bossek, Phalguni Chaudhuri, Willy Herrmann, Bernhard C. Menke, and Johannes WeissCite this: Inorg. Chem. 1982, 21, 12, 4308–4314Publication Date (Print):December 1, 1982Publication History Published online1 May 2002Published inissue 1 December 1982https://pubs.acs.org/doi/10.1021/ic00142a037https://doi.org/10.1021/ic00142a037research-articleACS PublicationsRequest reuse permissionsArticle Views1146Altmetric-Citations119LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Microjet printing of high-precision microlens array for packaging of fiber optic components (2002)

A significant advance in technical capability has recently been achieved in the fabrication of refractive microlens arrays by microjet printing. This advance enables control of lens diameter and center-to-center distances to accuracies on the order of +/- 1 micrometers , and of focal length variations within an array to less than the +/- 1%. Such accuracies are especially important for microlens arrays used for MOEMs device interconnects to optical fibers because of the relatively long free space optical path lengths required for such applications. The new process also enables the printing of microlenses of a given diameter with aspect ratios and focal lengths varying over a wide range (e.g., f/1-f/5). The profile of plano-convex microlenses printed by this method have exhibited less than a quarter wavelength of deviation from spherical surface. The thermal durability of the optical epoxies used for microlens printing enables both cycling temperature up to 200 degree(s)C and continuous exposure to thousands of hours at 85 degree(s)C, without affecting microlens performance. The microjet printing of lensed fibers provides another solution for fiber beam shaping and collimation with low production cost.
Isolated heart transplantation for familial transthyretin (TTR) V122I cardiac amyloidosis (2014)

Transthyretin (TTR) cardiac amyloidosis is characterized by deposition of either mutant or wild type TTR amyloid protein in the myocardium ultimately leading to progressive cardiomyopathy and heart failure. The most common TTR gene mutation that leads to TTR cardiac amyloidosis is the valine-to-isoleucine substitution at position 122 (V122I or Ile122). Currently, the only definitive treatment suggested for mutant TTR cardiac amyloidosis is the combined or sequential liver-heart transplantation in eligible patients, since liver is the source of TTR production. Here, we report a case of heterozygous Val122L mutated TTR-related cardiac amyloidosis treated with isolated heart transplantation with no recurrence of amyloid in the cardiac allograft and no systemic abnormalities 5 years after heart transplantation. Abbreviations MMF mycophenolate mofetil NYHA New York Heart Association TTR transthyretin VE minute ventilation.
A direct sampling multi-channel receiver for DOCSIS 3.0 in 65nm CMOS (2011)

This paper presents a fully integrated direct sampling receiver for DOCSIS 3.0, consisting of a time-interleaved ADC, a digital multi-channel selection filter, and a PLL. The receiver can simultaneously receive 4 streams from arbitrary RF frequencies between 48 and 1002MHz and output these in a 13.5MS/s digital IQ format or at a low-IF through integrated DACs. It consumes 980mW from a split 1.2/1.3/1.6V supply when receiving 4 channels and occupies 16.8mm2 in 65nm CMOS.
Optical amplifier configurations with low polarisation sensitivity (1987)

The sensitivity of optical amplifiers to signal polarisation is avoided with use of configurations in which two amplifiers are combined. We describe experiments with a series and a parallel arrangement of two optical amplifiers. The experiments demonstrate a polarisation-insensitive amplification for both configurations over a spectral range of at least 80 GHz.
Steroid-insensitive tobacco smoke-induced lung inflammation models in the mouse (2013)

Methods Female mice were exposed daily to TS for 4 or 11 days. Control animals were exposed to air. Mice were killed 24hrs after the last TS-exposure, lungs lavaged and prepared for histological assessment. Steroids were given orally (dexamethasone (DEX) 300ug/kg; budesonide (BUD) 10mg/kg, 1hr prior to, and 6hrs after each TS exposure) or intra-nasally (fluticasone proprionate (FP), DEX , BUD, beclomethasone, mometasone and ciclesonide dosed at 100-500ug/kg 1hr prior to each TS-exposure). Steroid efficacy was also investigated in a mouse LPS lung inflammation model.
Role of cannabis in inflammatory bowel diseases (2020)

For many centuries, cannabis (marijuana) has been used for both recreational and medicinal purposes. Currently, there are about 192 million cannabis users worldwide, constituting approximately 3.9% of the global population. Cannabis comprises more than 70 aromatic hydrocarbon compounds known as cannabinoids. Endogenous circulating cannabinoids, or endocannabinoids, such as anandamide and 2-arachidonoyl-glycerol, their metabolizing enzymes (fatty acid amide hydrolase and monoacylglycerol lipase) and 2 G-protein coupled cannabinoid receptors, CB1 and CB2, together represent the endocannabinoid system and are present throughout the human body. In the gastrointestinal (GI) tract, the activated endocannabinoid system reduces gut motility, intestinal secretion and epithelial permeability, and induces inflammatory leukocyte recruitment and immune modulation through the cannabinoid receptors present in the enteric nervous and immune systems. Because of the effects of cannabinoids on the GI tract, attempts have been made to investigate their medicinal properties, particularly for GI disorders such as pancreatitis, hepatitis, and inflammatory bowel diseases (IBD). The effects of cannabis on IBD have been elucidated in several small observational and placebo-controlled studies, but with varied results. The small sample size and short follow-up duration in these studies make it difficult to show the clear benefits of cannabis in IBD. However, cannabis is now being considered as a potential drug for inflammatory GI conditions, particularly IBD, because of its spreading legalization in the United States and other countries and the growing trend in its use. More high-quality controlled studies are warranted to elucidate the mechanism and benefits of cannabis use as a possible option in IBD management.
Considerations of magnetic resonance angiography by selective inversion recovery (1988)

In the selective inversion recovery method for projection angiography, upstream blood is tagged by an inversion excitation and then allowed to flow into the imaged region. The subtraction of this first image from a second image acquired without the tagging leaves a signal from only the selectively tagged blood. Pulse sequence design involves consideration of the duration of the blood transit interval, excitation timing and cardiac gating, static material suppression, inversion excitation pulses, and flow compensation. Each of these considerations must be viewed with respect to the particular application. The method has demonstrated potential application to areas such as the carotid arteries, aortic arch, and peripheral vessels.
Semi-supervised machine learning approach for unknown malicious software detection (2014)

Inductive bias represents an important factor in learning theory, as it can shape the generalization properties of a learning machine. This paper shows that biased regularization can be used as inductive bias to effectively tackle the semi-supervised classification problem. Thus, semi-supervised learning is formalized as a supervised learning problem biased by an unsupervised reference solution. The proposed framework has been tested on a malware-detection problem. Experimental results confirmed the effectiveness of the semi-supervised methodology presented in this paper.
A novel in vitro and in situ immunoassay biosensor based on fiber optic Fabry-Perot interferometry (2004)

This paper proposes a novel fiber optic immunoassay biosensor based on the Fabry-Perot (F-P) interferometry. The PDMS dip coating and self-assembly monolayers coating are employed to prepare the fiber probes in the formation of F-P cavity and modification of the tip surface respectively. As the fiber probe inserting into the target solution, the immunoreaction will be introduced on the fiber tip. The covalent binding of the Rabbit IgG and Anti Rabbit IgG-Cy3 molecules on the fiber tip will contribute to the variation of the refractive index of interface as well as the reflectance. The interference spectrum will be shifted due to the reflectance variation. The time response is also implemented by taking the in-situ measurement of spectrum valley shift and the signal will reach the steady state within 15 minutes. Finally, the sensitivity of this immunoassay biosensor has also been demonstrated that the lowest detectable concentration of the target sample Anti Rabbit IgG-Cy3 is 10<sup>-12</sup> g/ml, which is lower than the detection limit of ELISA of 5*10<sup>-11</sup> g/ml. This fiber optic immunoassay biosensor will be applied in the brain resarch for in-vivo and in-situ monitoring the biochemical reactions of the neurocytes.
Millimeter-wave receiver based on a folded dipole antenna and Schottky diode for maximum power transfer (2012)

In this article a millimeter-wave (mm-wave) receiver based on a folded dipole antenna, zero bias Schottky diode and silicon (Si) lens is presented. The antenna is designed in such a way that its input impedance is equal to the conjugate of the input impedance of the diode, so conjugate matching between antenna and diode is obtained and maximum power transfer between them is achieved. A first prototype working at 75GHz with 10mm diameter Si lens has been manufactured and measured.
Elevated Temperature Increases Heat Shock Protein 70 Synthesis in Bovine Two-Cell Embryos and Compromises Function of Maturing Oocytes1 (1996)

Exposure of heifers to heat stress during oocyte maturation leads to embryos with reduced development. The objectives of the present study were threefold: 1) to evaluate effects of heat shock on oocyte function as assessed by cleavage and development, and associated effects on membrane integrity and protein synthesis, 2) to determine whether responses of oocytes to heat shock are modified by the presence of cumulus cells, and 3) to determine whether oocytes and 2-cell embryos are capable of synthesizing heat shock proteins in response to heat shock. Exposure of cumulus oocyte complexes (COCs) to 41 degrees C did not alter the number of embryos that cleaved but reduced the number that developed to the blastocyst stage. In contrast, exposure to 42 degrees C reduced both cleavage and development rates. Maturation of COCs for 12 or 24 h at 41 degrees C or 42 degrees C did not affect membrane integrity as determined by fluorescein diacetate/ethidium reduced protein synthesis by oocytes when occurring during the first or last 12 h of maturation. Removal of cumulus cells prior to maturation reduced protein synthesis by oocytes; furthermore, exposure to 42 degrees C caused a greater percentage of reduction in protein synthesis in denuded oocytes than in those with intact cumulus. Analysis of [35S]methionine and [35S]cysteine-labeled proteins by two-dimensional SDS-PAGE and fluorography showed that nonmatured oocytes at 39 degrees C produced heat shock protein 68 (HSP68) and two other putative heat shock proteins of 71 and 70 kDa (P71 and P70, respectively); exposure to 42 degrees C did not increase synthesis of any of these proteins. The same was true for matured oocytes, except that P71 was absent at 39 degrees C and 42 degrees C. Two-cell embryos synthesized P70, P71, and slight amounts of HSP68 at 39 degrees C; HSP68 synthesis was greatly increased at 42 degrees C. Results indicate that oocyte thermolability may be due to alterations in protein synthesis and absence of heat inducibility of heat shock proteins. Further, heat shock of bovine embryos induces alterations in protein synthesis and possibly gene expression as early as the 2-cell stage of development. Results also suggest a possible thermoprotective role for cumulus cells during oocyte maturation.