gebhart/patrepeval huggingface dataset:
Excitation and dissociation of isolated ions derived from polycyclic aromatic hydrocarbons (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTExcitation and dissociation of isolated ions derived from polycyclic aromatic hydrocarbonsSteven J. Pachuta, Hilkka I. Kenttamaa, Thomas M. Sack, Ronald L. Cerny, Kenneth B. Tomer, Michael L. Gross, Robin R. Pachuta, and R. Graham. CooksCite this: J. Am. Chem. Soc. 1988, 110, 3, 657–665Publication Date (Print):February 3, 1988Publication History Published online1 May 2002Published inissue 3 February 1988https://pubs.acs.org/doi/10.1021/ja00211a001https://doi.org/10.1021/ja00211a001research-articleACS PublicationsRequest reuse permissionsArticle Views314Altmetric-Citations71LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Comparative analysis of the quantization of color spaces on the basis of the CIELAB color-difference formula (1997)

This article discusses the CIELAB color spave within the limits of optimal colors including the complete volume of object colors. A graphical representation of this color space is composed of planes of constant lightness L * with an net of lines parallel to the a * and b * axes. This uniform net is projected onto a number of other color spaces (CIE XYZ, tristimulus RGB, predistorted RGB, and YCC color space) to demonstrate and study the structure of color differences in these spaces on the basis of CIELAB color difference formulas. Two formulas are considered: the CIE 1976 formula *** and the newer CiE 1994 formula ***. The various color spaces considered are uniformly quantized and the grid of quantized points is transformed into CIELAB colordinates to study the distribution of color differences due to basic quantization steps and to spacify the areas of the colors with the highest sensitivity to color discrimination. From a threshold value for the maximum color difference among neighboring quantized points searched for in each color space, concepts for the quantization of the color spaces are drived. The results are compared to quantization concepts based on average values of quantization errors published in previous work. In addition to color spaces bounded by the optimal colors, the studies are also applied to device-dependent color spaces limited by the range of a positive RGB cube or by the gamut of colors of practical print processes (thermal dye sublimation, chromalin, and match print). For all the color spaces, estimation of the number of distinguishable colors are given on the basis of a threshold value for the color difference perception of *** = 1 and *** = 1.
The influence of true counting rate and the photopeak fraction of detected events on Anger camera deadtime. (1974)

As true counting rate (N) is increased, an in creasing proportion of photopeak events go unrecorded by the Anger camera due to its pulse pair resolving time (T). With increasing radio active source strength, the observed counting rate (R) is shown to reach a maximum (Rmqz) and then decrease. The resolving time (T) can be estimated by T = (eRn,az) @ and used in the
A computerized system for measurement of transient and equilibrium extrudate swell (1988)

Abstract A computerized automatic die swell apparatus has been designed and constructed. The apparatus provides both digital and analog outputs regarding the diameter of the molten extrudate and its variation with time. Precautions are made to reduce the effects of gravitational sag and temperature changes. The apparatus was used in conjunction with an Instron capillary rheometer to measure the transient and equilibrium extrudate swell behaviour of five low density polyethylene resins, a short fiber glass filled polypropylene melt, and a thermotropic liquid crystal polymer.
Superplastic Forging of Ti Powder Preforms. (1991)

Titanium alloy GT33 was designed by NRIM to have good-superplasticity at working temperature
Microbial Inactivation by Cupric Ion in Combination with H<sub>2</sub>O<sub>2</sub>: Role of Reactive Oxidants (2013)

The cupric ion mediated inactivation of Escherichia coli was enhanced by the presence of hydrogen peroxide (H2O2), with increasing inactivation efficacy observed in response to increasing concentrations of H2O2. The biocidal activity of the Cu(II)/H2O2 system is believed to result from the oxidative stress caused by reactive oxidants such as the hydroxyl radical ((•)OH), cupryl species (Cu(III)), and the superoxide radical (O2(•-)), which are produced via the catalytic decomposition of H2O2. In E. coli cells treated with Cu(II) and H2O2, the intracellular level of (•)OH and Cu(III) increased significantly, leading to complete disruption of cell membranes. On the basis of experimental observations made using an (•)OH scavenger, copper-chelating agents, and superoxide dismutase, it is concluded that Cu(III) is the predominant species responsible for the death of E. coli cells. It was also found that the production of Cu(III) was promoted by the reactions of copper with intracellular O2(•-). MS2 coliphage was found to be even more susceptible than E. coli to the oxidative stress induced by the Cu(II)/H2O2 system.
Inhibition of Bax protects neuronal cells from oligomeric Aβ neurotoxicity (2012)

Although oligomeric β-amyloid (Aβ) has been suggested to have an important role in Alzheimer disease (AD), the mechanism(s) of how Aβ induces neuronal cell death has not been fully identified. The balance of pro- and anti-apoptotic Bcl-2 family proteins (e.g., Bcl-2 and Bcl-w versus Bad, Bim and Bax) has been known to have a role in neuronal cell death and, importantly, expression levels of these proteins are reportedly altered in the vulnerable neurons in AD. However, the roles of apoptotic proteins in oligomeric Aβ-induced cell death remain unclear in vivo or in more physiologically relevant models. In addition, no study to date has examined whether Bax is required for the toxicity of oligomeric Aβ. Here, we found that treatment with oligomeric Aβ increased Bim levels but decreased Bcl-2 levels, leading to the activation of Bax and neuronal cell death in hippocampal slice culture and in vivo. Furthermore, the inhibition of Bax activity either by Bax-inhibiting peptide or bax gene knockout significantly prevented oligomeric Aβ-induced neuronal cell death. These findings are first to demonstrate that Bax has an essential role in oligomeric Aβ-induced neuronal cell death, and that the targeting of Bax may be a therapeutic approach for AD.
A synthetic peptide derivative that is a cholecystokinin receptor antagonist. (1987)

So far, there are no known peptidic effective receptor antagonists of both peripheral and central effects of cholecystokinin (CCK). Here, we describe a synthetic peptide derivative of CCK, t-butyloxycarbonyl-Tyr(SO3-)-Met-Gly-D-Trp-Nle-Asp 2-phenylethyl ester 1 (where Nle is norleucine), which is a potent CCK receptor antagonist. In rat and guinea pig dispersed pancreatic acini, this peptide derivative did not alter amylase secretion, but was able to antagonize the stimulation caused by cholecystokinin-related agonists. It caused a parallel rightward shift in the dose-response curve for the stimulation of amylase secretion with half-maximal inhibition of CCK-8-stimulated amylase release at a concentration of about 0.1 microM. Compound 1 was able to inhibit the binding of labeled CCK-9 (the C-terminal nonapeptide of CCK) to rat and guinea pig pancreatic acini (IC50 = 5 X 10(-8) M) as well as to guinea pig cerebral cortical membranes (IC50 = 5 X 10(-7) M). These results indicate that Compound 1 is a potent competitive CCK receptor antagonist.
Divergent Effects of Short‐Term, Very‐Low‐Calorie Diet on Insulin‐Like Growth Factor‐I and Insulin‐Like Growth Factor Binding Protein‐3 Serum Concentrations in Premenopausal Women with Obesity (1998)

Our study suggests that visceral adipose tissue, rather than adiposity per se, accounts for IGF-I and IGFBP-3 serum concentrations, and that rapid weight loss, possibly due to nutritional changes, results in lower IGF-I concentrations, higher IGFBP-3 concentrations, and abrogation of the inverse associations of VAT with IGF-I and IGFBP-3.
Simplified technique for identification of the aerobic spore-forming bacteria by phenotype. (2001)

The use of modern research approaches of genetics, biochemistry and molecular biology has led to progress in bacterial taxonomy. Systematic study of the aerobic spore-forming bacteria has resulted in the realignment of the genus Bacillus into several new genera. In the meantime, the identification process has become more difficult for the non-specialist in Bacillus taxonomy. This paper presents a key for the simplified phenotypic identification of the mesophilic, aerobic, spore-forming bacteria belonging to the genera Bacillus, Paenibacillus, Brevibacillus, Aneurinibacillus, Geobacillus and Virgibacillus. A total of 81 species were included and 115 morphological and physiological tests were analysed for their discriminative efficiency. This key is practical for rough but quick identification of aerobic spore-forming bacteria isolated from nature. Such preliminary identification will be helpful for the selection of reference strains and methods for more precise identification using the newest techniques. The reliability of the proposed identification key was tested on 100 cultures from the Ukrainian Collection of Microorganisms. The developed identification key is represented in interactive mode on a website (http://www/imv.kiev.ua/key/).
Chlorination Byproducts Formation Potentials of Typical Nitrogenous Organic Compounds (2006)

Wastewater reuse is an effective solution to mitigate water shortage problems in urban areas,and disinfection is necessary to ensure the quality of the reclaimed water.Although chlorine has been widely used to kill pathogenic organisms,it produces disinfection byproducts that contain toxicity,mutagenicity,carcinogenicity and teratogenicity.Nitrogenous organic compounds are important disinfection byproduct precursors.The formation potentials of chloroform,haloacetic acids,haloacetonitriles,chloropicrin,1,1-Dichloropropanone,and 1,1,1-Trichloropropanone during the chlorination of 20 elementary amino acids were studied.The results show that the formation potentials of the disinfection byproducts of the amino acids are related with their-R structures.Tryptophan and tyrosine with active phenyl in their-R structures have high formation potentials of chloroform,haloacetic acids and haloacetonitriles.
Simultaneous multiple 3D motion estimation via mode finding on Lie groups (2005)

We propose a new method to estimate multiple rigid motions from noisy 3D point correspondences in the presence of outliers. The method does not require prior specification of number of motion groups and estimates all the motion parameters simultaneously. We start with generating samples from the rigid motion distribution. The motion parameters are then estimated via mode finding operations on the sampled distribution. Since rigid motions do not lie on a vector space, classical statistical methods can not be used for mode finding. We develop a mean shift algorithm which estimates modes of the sampled distribution using the Lie group structure of the rigid motions. We also show that proposed mean shift algorithm is general and can be applied to any distribution having a matrix Lie group structure. Experimental results on synthetic and real image data demonstrate the superior performance of the algorithm.
Overexpression of <i>DPAGT1</i> Leads to Aberrant <i>N</i> -Glycosylation of E-Cadherin and Cellular Discohesion in Oral Cancer (2009)

Cancer cells are frequently characterized by aberrant increases in protein N-glycosylation and by disruption of E-cadherin-mediated adherens junctions. The relationship between altered N-glycosylation and loss of E-cadherin adhesion in cancer, however, remains unclear. Previously, we reported that complex N-glycans on the extracellular domains of E-cadherin inhibited the formation of mature adherens junctions. Here, we examined whether dysregulated N-glycosylation was one of the underlying causes for cellular discohesion in oral cancer. We show that dense cultures of human salivary epidermoid carcinoma A253 cells exhibited elevated expression of DPAGT1, the gene that initiates protein N-glycosylation. Overexpression of DPAGT1 correlated with the production of E-cadherin-bearing complex N-glycans in nascent adherens junctions. Partial inhibition of DPAGT1 with small interfering RNA reduced the complex N-glycans of E-cadherin and increased the abundance of alpha-catenin and stabilizing proteins in adherens junctions. This was associated with the assembly of functional tight junctions. The inverse relationship between DPAGT1 expression and intercellular adhesion was a feature of oral squamous cell carcinoma. Oral squamous cell carcinomas displayed overexpression of DPAGT1 that correlated with diminished localization of E-cadherin and alpha-catenin at the sites of adherens junctions. Our studies show for the first time that DPAGT1 is an upstream regulator of E-cadherin N-glycosylation status and adherens junction composition and suggest that dysregulation of DPAGT1 causes disturbances in intercellular adhesion in oral cancer.
A directional coupler of a vertically installed planar circuit structure (1988)

A 3-dB directional coupler is described which is fabricated by installing a vertical second printed circuit board on a main printed circuit board. The added vertical substrate significantly increases the freedom of design parameters. Coupling parameters are easily controlled by changing either the dielectric constants or the thicknesses of the substrates. This makes almost any coupling constant available along with good isolation and a suitable input impedance. The three-dimensional structure also makes a good use of space, resulting in a compact circuit structure. Experimental results agree well with a numerical calculation based on the boundary-element method and show the relaxed tolerances possible in fabrication. Effective permittivities and characteristic impedances for both even and odd modes were obtained and were substituted into the scattering matrix to obtain the parameters for a symmetrical directional coupler. A simplified design chart is also provided showing the dependence of characteristic impedances for odd and even modes on substrate thicknesses used.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
α-Arylation of Cyclic Amines by Aryl Transfer in Lithiated Ureas (2009)

Treatment with base of N′-aryl urea derivatives of hetero-or carbocyclic amines with benzylic nitrogen atoms promotes rearrangement with transfer of the aryl ring from N to C, giving rise to α-arylated products.
Using high-density DNA methylation arrays to profile copy number alterations (2014)

The integration of genomic and epigenomic data is an increasingly popular approach for studying the complex mechanisms driving cancer development. We have developed a method for evaluating both methylation and copy number from high-density DNA methylation arrays. Comparing copy number data from Infinium HumanMethylation450 BeadChips and SNP arrays, we demonstrate that Infinium arrays detect copy number alterations with the sensitivity of SNP platforms. These results show that high-density methylation arrays provide a robust and economic platform for detecting copy number and methylation changes in a single experiment. Our method is available in the ChAMP Bioconductor package: http://www.bioconductor.org/packages/2.13/bioc/html/ChAMP.html.
Development of a 300 kW CW L-band industrial heating magnetron (2004)

An industrial heating magnetron operating in L-band (915 MHz) and capable of producing 300 kW of continuous microwave power has been developed and is available for commercial sale. This high average power magnetron design, model CWM-300L is based on the presently-available CTL model CWM-75L, an L-band magnetron that produces 75 kW of continuous microwave power. The 300L magnetron operates at 32 kV and 10 A with a conversion efficiency exceeding 90% when freshly conditioned. To address specific problems, a paper-design version of the 300L is available although that new design has been neither fabricated nor tested.
Evaluating a Global Vector Autoregression for Forecasting (2012)

Global vector autoregressions (GVARs) have several attractive features: multiple potential channels for the international transmission of macroeconomic and financial shocks, a standardized economically appealing choice of variables for each country or region examined, systematic treatment of long-run properties through cointegration analysis, and flexible dynamic specification through vector error correction modeling. Pesaran, Schuermann, and Smith (2009) generate and evaluate forecasts from a paradigm GVAR with 26 countries, based on Dées, di Mauro, Pesaran, and Smith (2007). The current paper empirically assesses the GVAR in Dées, di Mauro, Pesaran, and Smith (2007) with impulse indicator saturation (IIS)—a new generic procedure for evaluating parameter constancy, which is a central element in model-based forecasting. The empirical results indicate substantial room for an improved, more robust specification of that GVAR. Some tests are suggestive of how to achieve such improvements.
A real-time collision detection between virtual and real objects based on three-dimensional tracking of hand (2010)

In the working environment of argument reality, users interact with virtual objects by hands. Making real-time collision detection between virtual and real objects is very essential to enhance the immersion and authenticity of the environment. In this paper, the key points of hand are marked by color block. We use a pair of common web cameras to collect images and track the points. Then the stereo vision calibration algorithm is achieved. We get hand positioning by calculating the disparity of key points between two images and restoring the three-dimensional position. At the same time, the virtual object models are divided to a binary tree and pretreated by the OBB bounding box. At last, the accurate collision detection is achieved by calculating the relative position between real hand and virtual objects real-time.
The impact of interprocedural class analysis on optimization (1995)

The runtime performance of object-oriented languages often suffers due to the overhead of dynamic dispatching. In order to make these languages competitive with traditional languages, optimizing compilers attempt to eliminate as many of the dynamic dispatches as possible. A variety of local and intraprocedural techniques have been developed to do this, but they can be ineffective when they are unable to statically bind and inline a message send. To enable better analysis across noninlined message sends, interprocedural analysis is required. In this paper we describe a simple algorithm for interprocedural class analysis and empirically evaluate its effectiveness as a tool for program optimization. We demonstrate that interprocedural class analysis can substantially decrease application execution times when compared to applications optimized with only intraprocedural techniques. * 1 Introduction Applications written in object-oriented languages often perform poorly when compared to equ...
Effect of bridge heterologous combination on sensitivity in enzyme immunoassay for cortisol. (1981)

The effect of the bridge heterologous combination of antiserum and enzyme-labeled steroid on sensitivity in heterogeneous enzyme immunoassay of cortisol has been investigated. The enzyme labeling of cortisol was carried out by the N-succinimidyl ester method. Four cortisol derivatives possessing different bridges at C-4 were covalently linked to β-galactosidase at various molar ratios of steroid to enzyme. The anti-cortisol antisera used were those raised against the conjugates of these haptenic derivatives with bovine serum albumin. The sensitivities obtainable with four homologous and twelve heterologous systems were tested. When thioether derivatives were used for enzyme labeling, the effectiveness of heterology on assay specificity was dependent upon the length of the bridge. It was found that the heterologous system using the steroid-enzyme conjugate obtained from a hapten having a shorter bridge than that used for antibody production resulted in an increase in sensitivity of the assay, whereas the use of a longer bridge was ineffective. This phenomenon can be explained in terms of the steric interaction between antibody and labeled enzyme.
Ca<sup>2+</sup>-Regulated Photoproteins:  Structural Insight into the Bioluminescence Mechanism (2004)

The bioluminescent jellyfish has contributed two famous proteins to modern science: green fluorescent protein or GFP, which finds wide use as a probe in cell biology studies, and aequorin, which has been used for intracellular calcium measurement for more than 30 years. More recently, obelin, a protein from the bioluminescent hydroid and also in the family of what are called “Ca2+-regulated photoproteins”, has been shown to have very attractive properties both in general applications and for basic structural biology investigations. This review will survey the new information into their molecular mechanism of bioluminescence action.
Coaxially mounted 67 GHz bandwidth InGaAs PIN photodiode (1986)

We report high-speed measurements of an InGaAs PIN photodiode in a millimetre-wave coaxial mount. The photodiode has an impulse response (including diode, parasitics and connector) of 9 ps FWHM and a 3 dB bandwidth of 67 GHz. This is the largest bandwidth reported to date for a photodiode in a coaxial mount with a connector.
Synthesis and Biological Evaluation of Novel Bouchardatine Derivatives as Potential Adipogenesis/Lipogenesis Inhibitors for Antiobesity Treatment (2015)

Our recent study has shown that the natural product bouchardatine (1) can reduce the triglyceride (TG) content in 3T3-L1 adipocytes (EC50 ≈ 25 μM). Here, we synthesized two series of compounds by introducing amine side chains at the 5 or 8 position of 1 and evaluated the lipid-lowering activity of derivatives. It was found that some of the compounds had significant lipid-lowering effects, and the most active compound 3d showed better activity (EC50 = 0.017 μM) than 2 (EC50 = 0.086 μM), a compound reported by us. Further, the mechanism studies revealed that 3d blocked TG accumulation via activation of the LKB1-AMPK signaling pathway, efficiently down-regulating the expression of key regulators of adipogenesis/lipogenesis. Cell uptake assay and confocal imaging of 3d in cells indicated that compound 3d had favorable cell permeability. Our results suggest that 3d may be a promising agent for the treatment of obesity and related metabolic disorders.