gebhart/patrepeval huggingface dataset:
Quantitative Analysis and Characterization of Infantile Spasms (1978)

An effective, time-synchronized monitoring system for the study of patients with infantile spasms has been developed. This system utilizes concurrent graphically recorded data, including EEG, body movement via triaxial accelerometry, respiration, electrocardiogram, electromyogram, electro-oculogram, and galvanic skin response. These data, when evaluated in conjunction with a closed-circuit TV recording of the patient, greatly facilitate the differentiation of seizures from nonictal activity and permit the characterization and quantification of the behavioral, motor, and autonomic phenomena intrinsically associated with infantile spasms.
Odd order MESFET multipliers with broadband, efficient, low spurious response (2002)

A novel circuit structure for odd order MESFET frequency multipliers has been developed using a generalized design approach. Improvements in efficiency, bandwidth and spurious harmonic rejection have been achieved via accurate models under large signal conditions.
Musculoskeletal Simulation Based Optimization of Rehabilitation Program (2006)

Rehabilitation is a complex multifaceted process with complexity and variability that depends not only on human patients and/or specialized equipment but also on the nature of their functional interaction. Rapid and effective customization of the functional interactions between the patient and the rehabilitation device thus becomes critical for any rehabilitation program. Two principal dimensions govern the effectiveness of such functional interactions: geometric placement of user-device (ergonomics) and exercise selection and performance (regimen). In this paper, we discuss aspects of creation of a virtual design environment, leveraging tools from musculoskeletal analysis, optimization, and simulation-based design, which will permit a therapist to rapidly evaluate and systematically customize various candidate rehabilitation programs. Specifically, this framework: (i) permits study of parametric performance variability due to ergonomic or regimen variability; and (ii) facilitates use of all design tools such as optimization to determine the best program. We illustrate various aspects of this customization using an illustrative case-study of a motor-rehabilitation haptic virtual driving environment
Assessment of bactericidal effects of quaternary ammonium-based antibacterial monomers in combination with colloidal platinum nanoparticles (2012)

Pretreatment of dentin using colloidal platinum nanoparticles (CPtN) can enhance the bond strength of dentin adhesives. However, the combination of CPtN, which is negatively charged, with cationic monomer-containing adhesive may reduce the antibacterial activity of the original material. Thus, the purpose of this study was to assess the effect of CPtN on the bactericidal activity of two cationic antibacterial monomers, 12-methacryloyloxydodecylpyridinium bromide (MDPB) and methacryloxylethyl cetyl dimethyl ammonium chloride (DMAE-CB). The rapid killing effects of the two monomers against planktonic or attached Streptococcus mutans in the presence or absence of CPtN were examined by viable cell counts. The measurement of minimum inhibitory and bactericidal concentrations demonstrated that CPtN up to 2.5 mM has no antibacterial activity. In the absence of CPtN, rapid killing of both planktonic and attached Streptococcus mutans were achieved by the two cationic monomers. Combination with 0.1 mM CPtN did not reduce the bactericidal effects of the two monomers, indicating that CPtN may be used as a pretreatment with antibacterial adhesives.
Overview: diagnosis of ischemic heart disease by noninvasive techniques. (1991)

Noninvasive tests have greatly improved in their ability to diagnose coronary artery disease. In addition, new testing modalities have been added to our armamentarium. However, no test is clearly superior to all others in every clinical circumstance. Moreover, none have been shown to provide sensitivities and specificities consistently above 90%. Therefore, their use for diagnostic purposes in populations with a lower prevalence of disease is only of moderate value. Conversely, for the assessment of the functional significance of coronary artery disease or prognosis in patients with ischemic heart disease, the addition of noninvasive imaging modalities to exercise testing is of high value.
Solving for the thickness and velocity of the weathering layer using 2-D refraction tomography (1992)

Abstract The weathering layer may be the most variable of all layers; yet in seismic processing, it is routinely taken to be uniform either in thickness or velocity. Datuming through an incorrect weathering model can corrupt the stack, possibly introducing false structure into deep reflectors. Recognizing that direct measurements of the weathering properties may not, in practice, be readily available, this paper investigates the feasibility of computing the weathering model from the traveltimes of refracted first arrivals. The problem is formulated in terms of the difference in arrival time at adjacent receivers, resulting in a much sparser matrix for inversion. Lateral variations in both the weathering thickness and velocity are sought; however, analysis indicates a fundamental long wavelength ambiguity in the solution, with gradual changes in velocity trading-off with gradual changes in thickness. In most cases, it is necessary to include a small number of constraints to obtain the true weathering model. Any roughness in the solution that is not required to fit the data is most effectively removed using a second difference smoothing technique.
Abstract LB-143: Sustained siRNA delivery by mesoporous silicon particles (2010)

Abstract RNA interference (RNAi) is a powerful approach for silencing genes associated with a variety of pathologic conditions; however, in vivo RNAi delivery has remained a major challenge due to lack of safe, efficient, and sustained systemic delivery. Here, we report on a novel approach to overcome these limitations using a multistage vector comprised of mesoporous silicon particles (S1MP) loaded with neutral nanoliposomes (DOPC) containing siRNA targeted against the oncoprotein, EphA2 that is overexpressed in a majority of cancers, including ovarian. Our delivery methodology resulted in sustained EphA2 gene silencing for at least 3 weeks in two independent orthotopic mouse models of ovarian cancer following a single intravenous administration of S1MP loaded with EphA2-siRNA-DOPC. Furthermore, a single administration of S1MP loaded with-EphA2-siRNA-DOPC substantially reduced tumor burden, angiogenesis and cell proliferation as compared to a non-coding control siRNA alone (SKOV3ip1: 54%, HeyA8: 57%), with no significant changes in serum chemistries or in pro-inflammatory cytokines. In summary, we have provided the first in vivo therapeutic validation of a novel, multistage siRNA delivery system for sustained gene silencing with broad applicability to pathologies beyond ovarian neoplasms. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr LB-143.
Quantum coding (1995)

A theorem is proven for quantum information theory that is analogous to the noiseless coding theorem of classical information theory. In the quantum result, the von Neumann entropy S of the density operator describing an ensemble of pure quantum signal states is equal to the number of spin-1/2 systems (``quantum bits'' or ``qubits'') necessary to represent the signal faithfully. The theorem holds whether or not the signal states are orthogonal. Related results are also presented about the fidelity of quantum coding and about representing entangled quantum states.
Low-Loss Silicon Waveguides and Grating Couplers Fabricated Using Anisotropic Wet Etching Technique (2016)

We report low-loss silicon waveguides and efficient grating coupler to couple light into them. By using anisotropic wet etching technique, we reduced the side wall roughness down to 1.2nm. The waveguides were patterned along the [112] direction on a [110] SOI substrate. The waveguide boundaries are decided by the [111] planes which are normal to the [110] surface. Fabricated waveguides show minimum propagation loss of 0.85 dB/cm for TE polarization and 1.08dB/cm for TM polarization. The fabricated grating couplers show coupling efficiency of -4.16dB at 1570nm with 3dB bandwidth of 46nm.
Electric-Field-Induced Localization and Oscillatory Electro-optical Properties of Semiconductor Superlattices (1988)

We show that the application of an electric field $F$ along the growth axis of a semiconductor superlattice results in a strong localization of the eigenstates, a blue shift of the optical-absorption edge, and the presence of oscillations periodic in ${F}^{\ensuremath{-}1}$. These unique electro-optical properties are derived here within the framework of a tight-binding description of the envelope functions and also from numerical solutions of the Schr\"odinger equation for a finite set of coupled quantum wells.
Use of Cartilage Grafts for Internal Septal Support of the Crooked Nose (2001)

The repair of a crooked nose relies on the successful straightening of the crooked septum. Failure to align the septum properly can compromise the final result. The versatility and effectiveness of using an open approach to repair the septal deformity are examined. The technique involves an extensive degloving of the septum, with a release of all extrinsic tethering attachments. This is followed by a direct repair of the intrinsic angulations of the septum, with cartilage splint grafts being applied to support and straighten the septum, and cartilage spreader grafts used to camouflage deviations and elevate segments of upper lateral cartilage collapse. Thirty-two patients were managed with this approach. The exposure is excellent, and the procedure is not difficult to perform because the steps are logical and anatomically based. The enhanced precision of repair results in greater predictability and an improved final result.
Viability and protein secretion from human Hepatoma (HepG2) cells encapsulated in 400‐μm polyacrylate microcapsules by submerged nozzle–liquid jet extrusion (1994)

An interfacial precipitation process to encapsulate mammalian cells in hydroxyethyl methacrylate-methyl methacrylate (HEMA-MMA) microcapsules of approximately 750 in approximately m diameter was previously described. It was not possible to produce smaller capsules due to low shearing force. A new droplet generation scheme was developed by suspending the cell and polymer co-extrusion nozzle in a uniform co-axial fluid jet which enabled the production of 300 to 600-microm diameter capsules. HepG2 hepatoma cells in 400-microm-diameter HEMA-MMA capsules were able to retain their metabolic activity during and after the encapsulation process. The in vitro secretion of plasma proteins alpha(1)-acid glycoprotein, alpha(1)-antitrypsin, and fibrinogen by the encapsulated cells was retained. The encapsulated cells secreted less fibrinogen (340 kD) relative to alpha(1)-acid glycoprotein (42kD), indicating the sieving effect (but not absolute cut-off) of the HEMA-MMA membrane. (c) 1994 John Wiley & Sons, Inc.
Sketch-based Image Retrieval via Shape Words (2015)

The explosive growth of touch screens has provided a good platform for sketch-based image retrieval. However, most previous works focused on low level descriptors of shapes and sketches. In this paper, we try to step forward and propose to leverage shape words descriptor for sketch-based image retrieval. First, the shape words are defined and an efficient algorithm is designed for shape words extraction. Then we generalize the classic Chamfer Matching algorithm to address the shape words matching problem. Finally, a novel inverted index structure is proposed to make shape words representation scalable to large scale image databases. Experimental results show that our method achieves competitive accuracy but requires much less memory, e.g., less than 3% of memory storage of MindFinder. Due to its competitive accuracy and low memory cost, our method can scale up to much larger database.
Identification of a 2,6‐dichloroisonicotinic‐acid‐sensitive protein kinase from tobacco by affinity chromatography on benzothiadiazole‐sepharose and NIM‐metal chelate adsorbent (2001)

In the search for the target site of inducers of systemic acquired resistance (SAR), a BTH-binding protein kinase (BBPK) has been identified from tobacco by affinity chromatography on benzothiadiazole-sepharose (CGA 324041-sepharose) and NIM-metal chelate affinity resin. The substrate selectivity of the isolated enzyme (phosphorylation of histone type III-S, I kappa B alpha,IkB alpha S32A/S36A and NIM1) suggested a possible BBPK-mediated regulation of NIM1 in tobacco. The measurement of the effect of different SAR-inducers showed an inhibition of BBPK by 2,6-dichloroisonicotinic acid (INA) and, to a lower extent, by benzothiadiazoles and salicylic acid. Comparison between BBPK cell-free inhibition and in vivo PR-1 induction revealed that BBPK could be the target site of INA.
Association between integrin expression and prognosis in localized prostate cancer (2010)

We have shown that the expression of integrin alpha3beta1 was independently associated with tumor recurrence after radical prostatectomy, suggesting that this integrin is a potential prognostic marker.
S-013 (2012)

Wilson, Sacoby; Wilson, Omega; Fraser-Rahim, Herb; Campbell, Dayna; Rice, LaShanta Author Information
Behandlung von Herzrhythmusstörungen mit Magnesium bei Patienten mit Herzinsuffizienz (2002)

Die medikamentöse Behandlung von Herzrhythmusstörungen ist unbefriedigend, da bei guter Wirksamkeit durch die Proarrhythmie eine Verbesserung der Prognose gefährdet und nicht gesichert ist. Man kann davon ausgehen, daß Magnesiumsalze keine arrhythmogene Effekte aufweisen. Bei Patienten mit einer Herzinsuffizienz besteht häufig ein Mg-Mangel, der durch gastrointestinale Störungen, neurohormonale Regulationen, aber auch durch die Therapie (Diuretika,Digitalis)bedingt ist. An Patienten mit einer Herzinsuffizienz müßte sich demnach zeigen lassen, ob die Mg-Substitution einen antiarrhythmischen Effekt aufweist. In fünf placebokontrollierten Studien konnte gezeigt werden, daß sich teil weise signifikant und mit ausreichen der Aussagekraft (Power)Arrhythmien bei Patienten mit Herzinsuffizienz durch orale und parenterale Gabe von Mg-Salzen reduzieren lassen. Trotz Einschränkungen wie z.B. inadäquates Design, fehlende Vermeidung von Bias, ungenügende Vergleichbarkeit der Behandlungsgruppen, inadäquate Auswertung und ungenügende Berücksichtigung der Spontanvariation läßt sich aufgrund der Ergebnisse der Studien die Hypothese aufstellen, daß Magnesiumsalze bei Patienten mit Herzinsuffizienz Herzrhythmusstörungen günstig beeinflussen können. Prospektive, randomisierte,verblindete und kontrollierte konfirmatorische Studien mit ausreichenden Fallzahlen sind jedoch notwendig, um diese Hypothese zu bestätigen.
Genetic Isolation, Cloning, and Analysis of a Mutator-Induced, Dominant Antimorph of the Maize amylose extender1 Locus (1993)

Philip S. Stinard, Donald S. Robertson, Patrick S. Schnable, Genetic Isolation, Cloning, and Analysis of a Mutator-Induced, Dominant Antimorph of the Maize amylose extender1 Locus, The Plant Cell, Vol. 5, No. 11 (Nov., 1993), pp. 1555-1566
New Modalities in the Treatment of Refractory Alopecia Areata (2017)

Alopecia areata (AA) is a common and complex T-cell–mediated inflammatory disorder. It may be patchy (localized), involve the entire scalp (alopecia totalis) or entire body (alopecia universalis). Alopecia totalis and universalis are often difficult to treat. Although many therapeutic options currently exist in alopecia areata, none of them are curative or preventive. Besides, none of them are approved by Food and Drug Administration (FDA). The disease unfortunately has an unpredictable course. The factors indicating a poor prognosis are the extent of hair loss at the presentation, long duration of the disease, and ophiasis pattern of hair loss. There are only a few randomized controlled studies conducted on recalcitrant AA. Recent research on immunology of hair follicle and recent developments in immunopathogenesis, together with the shared pathways of the disease with other autoimmune disorders, led investigators to focus on novel therapies that target specific immunological pathways. Herein, we will review shortly the current treatment options in recalcitrant alopecia areata based on recently published studies and then will focus on the recently developed broad-spectrum and targeted therapeutics.
Content discovery in opportunistic content-centric networks (2012)

Host-based mobile ad hoc communication requires the transmission of periodic hello beacons to identify neighbors. Drawing conclusions from received beacons, e.g., containing information about existence and neighbor nodes, to available or demanded content is not possible and the gathered information may be outdated quickly due to dynamic environment changes. Therefore, content-centric networking results in more flexible communication without the need of neighbor information. Instead, information about available content is required. In this paper, we will investigate two different content discovery strategies and discuss their efficiency for mobile communication. The algorithms have been implemented in the CCNx framework and evaluated in VirtualMesh, a hybrid emulation tool for wireless mobile ad hoc networks.
Comparison of solution structural flexibility and zinc binding domains for insulin, proinsulin, and miniproinsulin (1989)

The chromophoric divalent metal ion chelators 4-(2-pyridylazo)resorcinol (PAR) and 2,2',2"-terpyridine (terpy) are used as kinetic and spectroscopic probes to investigate in solution the SCN- -induced conformational transformations of the insulin, proinsulin, and miniproinsulin hexamers (miniproinsulin is a proinsulin analogue wherein the C-chain is replaced by a dipeptide cross-link between Gly-A1 and Ala-B30). Herein we designate the 2Zn and 4Zn crystal forms of the hexamer as the T6 and T3R3 conformations, respectively. For all three proteins, addition of SCN- reduces the rate of sequestering and removal of zinc ion by chelator. The effect of SCN- on the rate of this process saturates at the same concentration (30 mM) known to induce the T6 to T3R3 transformation in the insulin crystal. Under both T6 and T3R3 conditions, the critical stoichiometry for high-affinity interaction between Zn2+ and each of the three proteins is shown to be 2 mol of Zn2+/mol of protein hexamer. Consequently, we confirm the finding that off-axial coordination of Zn2+ via His-B10 and His-B5 residues is of minor importance for the SCN- -induced conformation change in solution [Renscheidt, H., Strassburger, W., Glatter, U., Wollmer, A., Dodson, G. G., & Mercola, D. A. (1984) Eur. J. Biochem. 142, 7-14]. Under T6 conditions, the kinetics of the reactions between insulin, proinsulin, and miniproinsulin and a variable excess of terpy are similar and biphasic.(ABSTRACT TRUNCATED AT 250 WORDS)
Clinical efficacy of the selective endothelin A receptor antagonist, atrasentan, in patients with diabetes and chronic kidney disease (CKD) (2012)

Edema formation was dose-dependent and occurred early. The decrease in urine NGAL warrants further study in renal tubular disease attenuation. UACR responses based on ethnicity need further characterization. Results suggest atrasentan may have additive effects to RAS inhibition in treatment of DN.
Therapeutic Mechanism in Seasonal Affective Disorder: Do Fluoxetine and Light Operate Through Advancing Circadian Phase? (2005)

In the context of Lewy's phase delay hypothesis, the present study tested whether effective treatment of winter Seasonal Affective Disorder (SAD) is mediated by advancing of circadian phase. Following a baseline week, 78 outpatients with SAD were randomized into 8 weeks of treatment with either fluoxetine and placebo light treatment or light treatment and placebo pill. Depression levels were measured on the Ham17+7 and the BDI-II, and circadian phase was estimated on the basis of daily sleep logs and self-reported morningness-eveningness. Among the 61 outpatients with complete data, both treatments were associated with significant antidepressant effect and phase advance. However, pre- and post-treatment comparisons found that the degree of symptom change did not correlate with the degree of phase change associated with treatment. The study therefore provides no evidence that circadian phase advance mediates the therapeutic mechanism in patients with SAD. Findings are discussed in terms of the limitations of the circadian measures employed.
The Impact of Video Compression on Remote Cardiac Pulse Measurement Using Imaging Photoplethysmography (2017)

Remote physiological measurement has great potential in healthcare and affective computing applications. Imaging photoplethysmography (iPPG) leverages digital cameras to recover the blood volume pulse from the human body. While the impact of video parameters such as resolution and frame rate on iPPG accuracy have been studied, there has not been a systematic analysis of video compression algorithms. We compared a set of commonly used video compression algorithms (x264 and x265) and varied the Constant Rate Factor (CRF) to measure pulse rate recovery for a range of bit rates (file sizes) and video qualities. We found that compression, even at a low CRF, degrades the blood volume pulse (BVP) signal-tonoise ratio considerably. However, the bit rate of a video can be substantially decreased (by a factor of over 1000) without destroying the BVP signal entirely. We found an approximately linear relationship between bit rate and BVP signal-to-noise ratio up to a CRF of 36. A faster decrease in SNR was observed for videos of the task involving larger head motions and the x265 algorithm appeared to work more effectively in these cases.
DEVELOPMENT OF THE GA-4 AND GA-9 LEGAL WEIGHT TRUCK SPENT FUEL SHIPPING CASKS (1991)

General Atomics (GA) is developing two legal-weight-truck spent-fuel shipping casks for transporting commercial reactor spent fuel. The GA-4 pressurized-water-reactor (PWR) and the GA-9 boiling-water-reactor (BWR) casks are stainless steel with non-circular cross sections. Depleted uranium (DU) and boron polypropylene are used for gamma and neutron shielding. Solid pellets of boron carbide contained in a removable stainless steel fuel support structure provide criticality control. The GA-4 Cask utilizes burnup credit to maintain a capacity of four spent fuel assemblies for enrichments greater than 3.0 U-235 wt%. Aluminum honeycomb impact limiters and a dedicated semitrailer contribute to the overall efficiency and safety of the system. Design verification testing of a half-scale model cask will confirm the adequacy of the structural design.