gebhart/patrepeval huggingface dataset:
Next-generation sequencing identifies the natural killer cell microRNA transcriptome (2010)

Natural killer (NK) cells are innate lymphocytes important for early host defense against infectious pathogens and surveillance against malignant transformation. Resting murine NK cells regulate the translation of effector molecule mRNAs (e.g., granzyme B, GzmB) through unclear molecular mechanisms. MicroRNAs (miRNAs) are small noncoding RNAs that post-transcriptionally regulate the translation of their mRNA targets, and are therefore candidates for mediating this control process. While the expression and importance of miRNAs in T and B lymphocytes have been established, little is known about miRNAs in NK cells. Here, we used two next-generation sequencing (NGS) platforms to define the miRNA transcriptomes of resting and cytokine-activated primary murine NK cells, with confirmation by quantitative real-time PCR (qRT-PCR) and microarrays. We delineate a bioinformatics analysis pipeline that identified 302 known and 21 novel mature miRNAs from sequences obtained from NK cell small RNA libraries. These miRNAs are expressed over a broad range and exhibit isomiR complexity, and a subset is differentially expressed following cytokine activation. Using these miRNA NGS data, miR-223 was identified as a mature miRNA present in resting NK cells with decreased expression following cytokine activation. Furthermore, we demonstrate that miR-223 specifically targets the 3' untranslated region of murine GzmB in vitro, indicating that this miRNA may contribute to control of GzmB translation in resting NK cells. Thus, the sequenced NK cell miRNA transcriptome provides a valuable framework for further elucidation of miRNA expression and function in NK cell biology.
Severe hepatitis E infection during pregnancy (1997)

In areas with endemic hepatitis E virus (HEV), acute liver failure secondary to hepatitis E infection is common in pregnancy and associated with a mortality rate of up to 20%. However, there is little information on the clinical course of severe hepatitis E infection during pregnancy in non-endemic areas such as the UK. Here we describe two cases of severe hepatitis E in pregnancy in patients returning from the Indian subcontinent. These cases were diagnosed by the detection of IgM anti-HEV antibody using an enzyme immunoassay with recombinant hepatitis E viral antigens. The first case describes acute hepatic failure, with coagulopathy and encephalopathy, warranting intensive therapy and elective ventilation. In the other case, the patient had severe hepatitis with coagulopathy. Both cases spontaneously resolved with no foetal loss. These cases highlight the need for suspicion of HEV infection in patients returning from endemic areas and presenting with acute non-A non-B hepatitis, especially when pregnant. Furthermore, the intensive treatment of acute liver failure caused by HEV may reduce the high mortality reported in Asia.
Guanylhydrazones with potential antileukemic activity. 1. Aza analogs of 4,4'-diacetyldiphenylurea bis(guanylhydrazone) (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGuanylhydrazones with potential antileukemic activity. 1. Aza analogs of 4,4'-diacetyldiphenylurea bis(guanylhydrazone)W. Korytnyk, A. C. Ghosh, N. Angelino, and C. DaveCite this: J. Med. Chem. 1973, 16, 8, 959–961Publication Date (Print):August 1, 1973Publication History Published online1 May 2002Published inissue 1 August 1973https://doi.org/10.1021/jm00266a025Request reuse permissionsArticle Views88Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (451 KB) Get e-Alertsclose Get e-Alerts
DOS file storage and retrieval: here's how DOS manages your hard disk data so that you can get to it fast (1991)

The external ear is composed of the auricle (pinna) and the external auditory canal. Both of these structures contain elastic cartilage (except the earlobe) and a small amount of subcutaneous fat, which are covered by skin. The skin of the cartilaginous canal contains hair cells, sebaceous (lipid-producing) glands, and apocrine (ceruminous) glands; this is in contrast with the osseous canal, which contains neither glands nor hair follicles. The auricle is susceptible to environmental influences and trauma. Due to its exposed locale, the ear is particularly vulnerable to the effects of ultraviolet light and, consequently, to preneoplastic and neoplastic skin lesions. The ear also has a sound-receiving function and a location that is both visible and aesthetically obvious, thereby drawing considerable attention from the patient. Dermatologic diseases on the external ear are seen in a variety of medical disciplines. Dermatologists, otorhinolaryngologists, family practitioners, and general and plastic surgeons are regularly consulted about cutaneous lesions on the ear. These lesions can be grouped into three main categories: (1) infectious; (2) tumoral; and (3) noninfectious inflammatory. The purposes of this contribution are to review various dermatologic diseases of the external ear and to update current diagnosis and treatment information related to these conditions.
BAG6/BAT3: emerging roles in quality control for nascent polypeptides (2012)

BAG6 (also known as BAT3/Scythe) is a ubiquitin-like protein that is thought to participate in a variety of seemingly unrelated physiological and pathological processes, such as apoptosis, antigen presentation and the T-cell response. Recent studies have shown that BAG6 is essential for the quality control of aggregation-prone polypeptide biogenesis. It forms part of a complex that determines the fate of newly synthesized client proteins for membrane insertion, ubiquitin-mediated degradation and/or aggregate formation. A biologically relevant transmembrane protein family has recently been shown to be a major client of BAG6, suggesting that many of the known diverse BAG6 functions can be interpreted by BAG6-mediated control of membrane protein biogenesis. In this review, we summarize the current understanding of the physiological roles of BAG6 with a particular focus on quality control for nascent chain polypeptides.
Occurrence of Leukemia and Lymphoma in Patients with Agammaglobulinemia (1963)

Abstract 1) Two case reports of children with congenital agammaglobulinemia who later developed malignant lymphoma are presented. 2) Two additional cases of malignant lymphoma developing in adult patients with hypogammaglobulinemia are reviewed. 3) The occurrence of diseases of this group among patients with this immunologic defect appears to be a greater-than-chance association. Possible reasons for the association are discussed.
Analysis of Porcine Optineurin and Myocilin Expression in Trabecular Meshwork Cells and Astrocytes from Optic Nerve Head (2004)

The high homology of porcine optineurin and myocilin to the comparable human genes indicates that pigs can be used to study changes in gene expression in hypertensive eyes. The alterations in expression of myocilin but not of optineurin under stress suggest that different mechanisms in the phenotype of glaucoma associated with the two genes are involved in development of glaucoma.
Location of Genes for Motility and Chemotaxis on the<i>Escherichia coli</i>Genetic Map (1969)

In Escherichia coli, the following genes are involved in motility and chemotaxis. The H gene is the structural gene for flagellin. Mutation in the mot gene results in paralysis of the flagella, and mutation in the fla genes leads to an absence of flagella. The cheA, cheB, and cheC genes are required for chemotaxis. The chromosomal location of these genes has now been determined. The majority are clustered in a small region around uvrC, between his and aroD, in the order his-cheC-H-uvrC-mot-cheA-cheB-aroD. The fla genes are located in the same region, and also between trp and gal. The results indicate that many of the genes are homologous to those which have been studied in Salmonella typhimurium.
WASTK: A Weighted Abstract Syntax Tree Kernel Method for Source Code Plagiarism Detection (2017)

In this paper, we introduce a source code plagiarism detection method, named WASTK (Weighted Abstract Syntax Tree Kernel), for computer science education. Different from other plagiarism detection methods, WASTK takes some aspects other than the similarity between programs into account. WASTK firstly transfers the source code of a program to an abstract syntax tree and then gets the similarity by calculating the tree kernel of two abstract syntax trees. To avoid misjudgment caused by trivial code snippets or frameworks given by instructors, an idea similar to TF-IDF (Term Frequency-Inverse Document Frequency) in the field of information retrieval is applied. Each node in an abstract syntax tree is assigned a weight by TF-IDF. WASTK is evaluated on different datasets and, as a result, performs much better than other popular methods like Sim and JPlag.
Alleged alkylations of α-hydroxyimines to betaines: revisions of the structure of educts and products (1984)

R. Friary and G. W. Kirby, J. Chem. Soc., Chem. Commun., 1984, 1383a DOI: 10.1039/C3984001383A
Visual terrain classification for selecting energy efficient gaits of a hexapod robot (2013)

Legged robots need to be able to classify and recognize different terrains to adapt their gait accordingly. Recent works in terrain classification use different types of sensors (like stereovision, 3D laser range, and tactile sensors) and their combination. However, such sensor systems require more computing power, produce extra load to legged robots, and/or might be difficult to install on a small size legged robot. In this work, we present an online terrain classification system. It uses only a monocular camera with a feature-based terrain classification algorithm which is robust to changes in illumination and view points. For this algorithm, we extract local features of terrains using either Scale Invariant Feature Transform (SIFT) or Speed Up Robust Feature (SURF). We encode the features using the Bag of Words (BoW) technique, and then classify the words using Support Vector Machines (SVMs) with a radial basis function kernel. We compare this feature-based approach with a color-based approach on the Caltech-256 benchmark as well as eight different terrain image sets (grass, gravel, pavement, sand, asphalt, floor, mud, and fine gravel). For terrain images, we observe up to 90% accuracy with the feature-based approach. Finally, this online terrain classification system is successfully applied to our small hexapod robot AMOS II. The output of the system providing terrain information is used as an input to its neural locomotion control to trigger an energy-efficient gait while traversing different terrains.
Transformation of multiple soybean cultivars by infecting cotyledonary-node with Agrobacterium tumefaciens (2006)

Transformation of four soybean cultivars (Nannong88-1, Nannong18-6, Yu23 and Nannong 87C-38) by infecting cotyledonary-node with Agrobacterium tumefaciens strain EHA105 harboring pBI121 containing GFP reporter gene was conducted. The results indicated that the addition of thiol compounds (L-cysteine, dithiothreitol and sodium thiosulfate) in co-cultivation period increased the transformation efficiency of all four soybean cultivars, with Nannong 88-1 most increased up to 2.20%. Detection of GFP expression in the rooted plants was an effective selection system for the confirmation of soybean transformation. And most GFP-positive plants were confirmed to be positive by Southern blot analysis, which showed that transformation of cotyledonary-node explants mediated by Agrobacterium delivered T-DNA with one or two copies into soybean genome. In our study, the combination of Nannong88-1 with EHA105 is the optimum selection for explant and bacterial inoculum in soybean transformation, which could be applied in future functional study of soybean genes.
Rapid Speaker Adaptation With Speaker Clustering (2002)

Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2002.
Study on simulation system for 3-axis NC milling (2002)

An efficient real-time simulation system for 3-axis NC milling using microcomputers is described in this paper. In this system, the workpiece is represented with an extended Z-map structure and is displayed on screen using isometric projection. After the NC code file was generated and interpreted by an NC instruction translator, a material removal process was simulated just like that performed on real NC milling machine tools driven by NC instructions. The whole process is real-time displayed on the screen; meanwhile alarm messages are given to the operator when interference between milling cutter and workpiece occurs. The simulation result is displayed using a visual realism technique, from which gross programming errors can be checked with ease. The function of each module in this simulation system is discussed in detail using an example. This system simulates NC milling processes efficiently on a microcomputer platform.
Closed-Form Orthogonal DFT Eigenvectors Generated by Complete Generalized Legendre Sequence (2008)

In this paper, we propose a new method for deriving the closed-form orthogonal discrete Fourier transform (DFT) eigenvectors of arbitrary length using the complete generalized Legendre sequence (CGLS). From the eigenvectors, we then develop a novel method for computing the DFT. By taking a specific eigendecomposition to the DFT matrix, after proper arrangement, we can derive a new fast DFT algorithm with systematic construction of an arbitrary length that reduces the number of multiplications needed as compared with the existing fast algorithm. Moreover, we can also use the proposed CGLS-like DFT eigenvectors to define a new type of the discrete fractional Fourier transform, which is efficient in implementation and effective for encryption and OFDM.
[Active substances in Valeriana officinalis L]. (1977)

The effect of a developing secondary flow, induced by both centrifugal and buoyancy forces, on heat transfer inside a horizontal curved pipe is studied. The governing equations are solved in a finite element formulation using tri-quadratic elements for the velocity as well as for the temp. field. Due to interaction of centrifugal, buoyancy and pressure forces, a complex secondary flow develops, consisting of two secondary longitudinal vortices, perpendicular to the axial flow. Heat transfer shows to be increased considerably as a result of the three-dimensional flow field
α/β-Hydrolase domain-containing 6 (ABHD6) negatively regulates the surface delivery and synaptic function of AMPA receptors (2016)

In the brain, AMPA-type glutamate receptors are major postsynaptic receptors at excitatory synapses that mediate fast neurotransmission and synaptic plasticity. α/β-Hydrolase domain-containing 6 (ABHD6), a monoacylglycerol lipase, was previously found to be a component of AMPA receptor macromolecular complexes, but its physiological significance in the function of AMPA receptors (AMPARs) has remained unclear. The present study shows that overexpression of ABHD6 in neurons drastically reduced excitatory neurotransmission mediated by AMPA but not by NMDA receptors at excitatory synapses. Inactivation of ABHD6 expression in neurons by either CRISPR/Cas9 or shRNA knockdown methods significantly increased excitatory neurotransmission at excitatory synapses. Interestingly, overexpression of ABHD6 reduced glutamate-induced currents and the surface expression of GluA1 in HEK293T cells expressing GluA1 and stargazin, suggesting a direct functional interaction between these two proteins. The C-terminal tail of GluA1 was required for the binding between of ABHD6 and GluA1. Mutagenesis analysis revealed a GFCLIPQ sequence in the GluA1 C terminus that was essential for the inhibitory effect of ABHD6. The hydrolase activity of ABHD6 was not required for the effects of ABHD6 on AMPAR function in either neurons or transfected HEK293T cells. Thus, these findings reveal a novel and unexpected mechanism governing AMPAR trafficking at synapses through ABHD6.
Heterogeneity of Myocardial Edema in Isolated Pig Hearts after Perfusion with Different Types of Cardioprotective Solutions (1998)

The extent and distribution of myocardial edema induced by perfusion with cardioprotective solutions is of great interest. Domestic pig hearts (n = 12) were perfused in situ after aortic cross clamping either with Bretschneider's cardioplegic solution (HTK, 4 degrees C, n = 3), with a heparinized Krebs-Henseleit solution containing 30 mmol/L 2,3 Butanedionemonoxime (BDM, 4 degrees C, n = 3) or with heparinized pig blood (HPB, 24 degrees C, n = 3). After a three-hours storage period, magnetic resonance tomography (MRI) was carried out. The acquired T1-weighted data were used for the subsequent three-dimensional reconstruction based on the "Heidelberg ray-tracing technique". The small myocardial tissue blocks (n = 216) were excised from these hearts for dry weight measurements for 9 preselected regions in duplicate including ventricular papillary muscle, ventricular free wall, ventricular septum, apex, and atrial tissue. In control hearts (n = 3), dry weight was measured immediately after explantation (no MRI). The results of dry-weight measurements and three dimensional visualization were compared. Dry-weight measurements revealed that considerable myocardial edema is induced by any of the experimental procedures. The effects were most pronounced after BDM perfusion. Regardless how the edema was induced, there were significant differences of the water content within the heart: the water content in the heads of the papillary muscles and in the interventricular septum was always smaller than that of the free left- and right-ventricular walls. The heterogeneity of myocardial edema and its spatial distribution pattern could be qualitatively visualized. The experimental data (biophysical data and 3D visualization) clearly show a heterogeneity of myocardial edema induced by different types of cardioprotective solutions. As the presence of myocardial edema represents one of the crucial events in the pathophysiology of myocardial dysfunction occurring during myocardial infarction, ischemia, heart transplantation, and extracorporeal circulation, the present study represents an interesting contribution towards intravital detection and distribution of myocardial edema.
Paramagnetic macrocyclic complexes as contrast agents for MR imaging: proton nuclear relaxation rate enhancement in aqueous solution and in rat tissues. (1986)

Paramagnetic macrocyclic chelates show promise as magnetic resonance (MR) imaging contrast agents due to stability and relaxivity comparable to those of DTPA-type chelates. For the three copper and manganese macrocyclic complexes studied in aqueous solution, T1 and T2 relaxivities ranged from 0.14 to 5.88 mM-1sec-1 at 6.25 MHz. In rats, the intravenous administration of 16 mumol/kg of Mn(cyclam) caused the liver T1 relaxation rate to double at 15 minutes after injection. T1 measurements by pulsed MR imaging and manganese analyses on excised tissue showed that both relaxation rate (1/T1) and manganese content of liver and kidney increase linearly with the dosage of Mn(cyclam). The linear relationship between 1/T1 and manganese content can be considered an "in tissue" relaxivity plot for the agent. The resulting relaxivity is 54 mM-1sec-1 in liver, compared with 3.1 mM-1sec-1 in aqueous solution. Although this work is preliminary, the implication for medical MR imaging applications is that macrocyclic contrast agents can be effective at approximately one-tenth the current typical dose used for gadolinium DTPA.
Use of pamidronate in chronic and acute bone loss conditions. (1997)

Involutional osteoporosis (OP), Osteogenesis imperfecta (OI) and Reflex sympathetic dystrophy syndrome (RSDS) are conditions in which an increase in bone resorption has been described. It therefore seems logical to prescribe a potent inhibitor of bone resorption like pamidronate (APD) in a patient suffering from any of these conditions. In our experience, oral as well as intravenous APD therapy was able to increase significantly bone mineral density (BMD) in patients with OP. This increase was more marked at the lumbar spine than at the proximal femur. With cyclical intermittent APD therapy, a plateauing effect in the BMD results during the third year appeared. After weaning from APD therapy, a remanent effect was observed: no loss of bone apparently occurred for at least two years, but the biological remodeling parameters re-increased earlier. The protective action on OP fractures has still to be clearly demonstrated, however. In children with OI, oral APD therapy has produced a dramatic increase in bone mass, without adversely interfering with the growth spur. The effect on fracture rate is still debatable in such a protean condition. Intravenous APD administered daily for twelve days has provoked a dramatic improvement in patients with long lasting RSDS which had resisted to various well-accepted therapies. However, this was an open trial, and these favorable preliminary results should be confirmed in a double-blind study.
FOXP3+ REGULATORY T-CELLS PLAY A DOMINANT ROLE OVER RORGAMMA+ TH17-CELLS IN DECEASED DONOR KIDNEYS (2008)

1 Internal Medicine, Erasmus MC, University Medical Center Rotterdam, The Netherlands, 2Surgery, Erasmus MC, University Medical Center Rotterdam, The Netherlands
Integrated biological process for the treatment of a Chilean complex gold ore (1993)

Ahstract: A process for gold recovery from a complex Chilean ore from Burladora (IV Region) which integrates concentration by flotation, bacterial leaching and cyanidation was studied at a laboratory scale.The chemical composition of the ore is ~.2',; Fc, 0.78% Cu. 0.88(:k As and 3.5 g/t Au, with pyrite, hematite, covelite, arsennpyrite and chalcopyrite as the main metal-bearing minerals.The initial gold recovery" by conventional cyanidation on a crushed ore sample was only 54(4.The ore was ground and concentrated by flotation with a gold recovery of only 56(;;.The gold content of the conccntratc is 17 g/I Au.Concentrate samples were leached in 1.5 1 stirred reactors at 10¢~ pulp density in 1000 ml of acid medium (pH 1.8).Some experiments wcre inoculated with harvested bacteria previously isolated from mining solutions.Dissolved metals, pH and bacteria concentration in the Icaching solutions were pcriodically determined.In the presence of bacteria, oxidation of the ferrous ion produced by acid dissolution of the concentrate was obsmwed, and after 4 days of leaching 1009,: of thc dissolved iron was present as ferric ion.Gold recovery by cyanidatkm increased from 13¢~ for the initial concentrate to 34G after 10 days of chemical acid leaching and 97% after 10 days of bacterial leaching.To increase the total gold recovery, the flotation tailings were submitted to cyanidation.A complete flowsheet of the process and a first economical evalualkm arc proposed.As a possible altcrnativc process, heap bacterial leaching and further cyanidation of the ore tire suggested.