gebhart/patrepeval huggingface dataset:
Monoclonal antibody that inhibits infection of HeLa and rhabdomyosarcoma cells by selected enteroviruses through receptor blockade (1986)

BALB/c mice were immunized with HeLa cells, and their spleen cells were fused with myeloma cells to produce hybridomas. Initial screening of culture fluids from 800 fusion products in a cell protection assay against coxsackievirus B3 (CB3) and the CB3-RD virus variant yielded five presumptive monoclonal antibodies with three specificities: protection against CB3 on HeLa, protection against CB3-RD on rhabdomyosarcoma (RD) cells, and protection against both viruses on the respective cells. Only one of the monoclonal antibodies (with dual specificity) survived two subclonings and was studied in detail. The antibody was determined to have an immunoglobulin G2a isotype and protected cells by blockade of cellular receptors, since attachment of [35S]methionine-labeled CB3 was inhibited by greater than 90%. The monoclonal antibody protected HeLa cells against infection by CB1, CB3, CB5, echovirus 6, and coxsackievirus A21 and RD cells against CB1-RD, CB3-RD, and CB5-RD virus variants. The monoclonal antibody did not protect either cell type against 16 other immunotypes of picornaviruses. The monoclonal antibody produced only positive fluorescence on those cells which were protected against infection, and 125I-labeled antibody confirmed the specific binding to HeLa and RD cells. The results suggest that this monoclonal antibody possesses some of the receptor specificity of the group B coxsackieviruses.
[Differential diagnosis in parkinsonism]. (1995)

Parkinsonism is an important cause of disability in elderly people. Parkinsonian syndromes fall into one of three major categories: Parkinson's disease, secondary (symptomatic) parkinsonism and parkinsonian syndromes occurring as one of the major manifestations of several neuronal system degenerations. Clinical differential diagnosis of parkinsonism may be difficult and studies, which correlate clinically diagnosed Parkinson's disease and the neuropathological findings in the same patients, have shown that 20-30% of these patients had another disease. The prognosis and treatment are different for parkinsonian syndromes and Parkinson's disease, and an accurate clinical diagnosis is thus important, both for research and for management of individual patients. The present article reviews some of the aspects of differential diagnosis of parkinsonism and gives guidelines as to practical diagnostic work with these patients. A new approach to diagnosis in Parkinson's disease is presented. The article also discusses the possible role of new diagnostic tools like imaging techniques and neurophysiological methods in the diagnosis of parkinsonism.
<title>Near-infrared spectroscopic reflectance imaging: methods for functional imaging and in-vivo monitoring</title> (1999)

Ten near infrared spectroscopic reflectance images were collected from the forearm of a volunteer subject during the course of two ischemia-reperfusion events, one involving complete circulator arrest (full ischemia), the other a compromised venous out flow (venous occlusion). The data from this time series of spectroscopic images was then analyzed using an unsupervised classification scheme. Fuzzy C-means clustering was performed on a spectroscopic imaging cube, on a time series of 760 nm optical density images extracted from the ten timepoints, and on the time series of hemodynamic images derived from applying a two-wavelength, non-isobestic point oxygen saturation algorithm and a six-wavelength ÆThemoglobin, Æoxyhemoglobin and Æcytochrome-aa3 algorithm to the spectra from each time point. Periods of full ischemia and venous occlusion cause very difference changes in the absorption, scattering and hemodynamic parameters of the forearm. The application of various algorithms to the spectra of each timepoint was successful to varying degrees. Near infrared spectroscopic imaging is shown to be an excellent technique to monitor spatial variations in the tissue response to ischemic events.
Intravenous Administration of Polyethylene Glycol-Coated (PEGylated) Proteins and PEGylated Adenovirus Elicits an Anti-PEG Immunoglobulin M Response (2012)

A single intravenous administration of polyethylene glycol-coated (PEGylated) bovine serum albumin (BSA) and ovalbumin (OVA) elicited an anti-PEG immunoglobulin M (IgM) response, similar to that from PEGylated liposomes, although the administration did not elicit specific neutralizing antibodies to BSA and OVA. A cross-reactivity was observed between anti-PEG IgMs elicited by PEG-BSA and PEGylated liposomes. The anti-PEG IgM level induced by PEGylated proteins (BSA and OVA) reached the maximum at day 5 following intravenous injection. This production pattern was consistent with that induced by PEGylated liposomes. Splenectomy suppressed the anti-PEG IgM response against PEG-BSA and PEGylated liposomes. These observations relating PEG-BSA and PEGylated liposomes indicate that PEGylated proteins might promote the immune responses against PEG with a mechanism similar to that of PEGylated liposomes. In addition, a single intravenous administration of PEGylated adenovirus (PEG-Ad) also elicited an anti-PEG IgM response in a PEG-modification ratio dependent manner. To the best of our knowledge, this is the first report showing that an intravenous administration can elicit an anti-PEG IgM response against PEGylated substances. It appears that anti-PEG IgMs can be produced by the systemic administration of a PEGylated substance and may limit the efficacy of PEGylated substances such as proteins, Ad vector and nanoparticles, due to a cross-reactivity seen in some patients. The immunogenicity of PEGylated substances is usually tested against those very substances, rather than against covalently attached PEG. Our study suggests that the PEG immunogenicity of PEGylated therapeutic agents and particles merits further investigation.
Workload characterization on a production Hadoop cluster: A case study on Taobao (2012)

MapReduce is becoming the state-of-the-art computing paradigm for processing large-scale datasets on a large cluster with tens or thousands of nodes. It has been widely used in various fields such as e-commerce, Web search, social networks, and scientific computation. Understanding the characteristics of MapReduce workloads is the key to achieving better configuration decisions and improving the system throughput. However, workload characterization of MapReduce, especially in a large-scale production environment, has not been well studied yet. To gain insight on MapReduce workloads, we collected a two-week workload trace from a 2,000-node Hadoop cluster at Taobao, which is the biggest online e-commerce enterprise in Asia, ranked 14 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sup> in the world as reported by Alexa. The workload trace covered 912,157 jobs, logged from Dec. 4 to Dec. 20, 2011. We characterized the workload at the granularity of job and task, respectively and concluded with a set of interesting observations. The results of workload characterization are representative and generally consistent with data platforms for e-commerce websites, which can help other researchers and engineers understand the performance and job characteristics of Hadoop in their production environments. In addition, we use these job analysis statistics to derive several implications for potential performance optimization solutions.
Nutrition Aspects of Gastroparesis and Therapies for Drug‐Refractory Patients (2006)

Gastroparesis, broadly defined as disordered gastric emptying, is a commonly encountered clinical problem. Nutrition problems frequently occur in gastroparesis, primarily due to inadequate oral intake but also due to losses from vomiting or diarrhea. Treatment of gastroparesis may include dietary modification with or without medication. Some patients require supplementation with either enteral or parenteral nutrition for survival. However, many patients with gastroparesis are drug-refractory and invariably do not do well with enteral or parenteral access. Historically, these patients have been without effective therapeutic options. The development of gastrointestinal electrical stimulation has allowed many with drug-refractory gastroparesis to be treated successfully. Enteric electrical stimulation for gastroparesis often corrects many of the nutrition abnormalities, along with improving symptoms and quality of life and reducing costs; for some categories of patients, it may improve survival rates.
Graphs, Hypergraphs, and the Complexity of Conjunctive Database Queries (Invited Talk) (2017)

The complexity of evaluating conjunctive queries can depend significantly on the structure of the query. For example, it is well known that various notions of acyclicity can make the evaluation problem tractable. More generally, it seems that the complexity is connected to the "treelikeness" of the graph or hypergraph describing the query structure. In the lecture, we will review some of the notions of treelikeness that were proposed in the literature and how they are relevant for the complexity of evaluating conjunctive queries and related problems.
Carcinogenic effects of acrylamide in Sencar and A/J mice. (1984)

Acrylamide structurally resembles vinyl carbamate, a proposed proximate carcinogenic form of ethyl carbamate. To test the hypothesis that acrylamide should possess carcinogenic properties, it was tested in the Salmonella-microsome assay for point mutation, as a skin tumor initiator in the Sencar mouse, and for its ability to induce lung adenomas in the A/J mouse. Acrylamide was found to be without activity as a mutagen in Salmonella strains TA 1535, TA 1537, TA 98, and TA 100 both in the presence and absence of rat liver microsomes using both the plate and liquid suspension assays. However, acrylamide was found to approximate ethyl carbamate in potency as a tumor initiator in the skin of the female Sencar mice. As with ethyl carbamate, acrylamide was more potent by systemic routes of administration relative to topical application. Acrylamide was also found to induce lung adenomas in male and female A/J mice using both the p.o. and i.p. routes of administration. Acrylamide was approximately one-seventh as potent as ethyl carbamate in the induction of lung adenomas. These data confirm the hypothesis that acrylamide possesses carcinogenic properties similar to ethyl carbamate.
High-Q LaAlO/sub 3/ dielectric resonator shielded by YBCO-films (1994)

We have investigated a dielectric resonator consisting of a single crystalline LaAlO/sub 3/-cylinder shielded by a cylindrically shaped copper cavity with endplates made from epitaxial films of YBa/sub 2/Cu/sub 3/O/sub 7/ or niobium. For YBa/sub 2/Cu/sub 3/O/sub 7/ films unloaded quality factors Q/sub 0/ of 4.5/spl middot/10/sup 5/ at 10 K and 1.3/spl middot/10/sup 5/ at 77 K were achieved at 11.6 GHz using a compact shielding cavity with a diameter of 15 mm and a height of 3.8 mm. The loss contributions of the dielectric resonator, the normal conducting cylinder wall, and the superconducting endplates, with one of them being separated by a small distance h from the dielectric cylinder, were calculated by modeling the electromagnetic fields of the TE/sub 0/spl nu//spl mu//-modes. The dielectric loss tangent of the LaAlO/sub 3/-cylinders was found to be 10/sup -6/ at 4.3 K and f=11.6 GHz and to increase slightly with temperature. Moreover, the calculations indicate the tunability of the resonance frequency by changing h over a range of 1 GHz without significant degradation of Q/sub 0/. These resonators are considered to be useful devices for stable oscillators and narrowband filters.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Mice Lacking Expression of the Chemokines Ccl21-Ser and Ccl19 (<i>plt</i> Mice) Demonstrate Delayed but Enhanced T Cell Immune Responses (2001)

The paucity of lymph node T cells (plt) mutation leads to a loss of CCL21 and CCL19 expression in secondary lymphoid organs. plt mice have defects in the migration of naive T cells and activated dendritic cells into the T cell zones of lymphoid organs, suggesting that they would have defects in T cell immune responses. We now demonstrate T cell responses in plt mice are delayed but ultimately enhanced. Responses to contact sensitization are decreased at day 2 after priming but increased at day 6. After subcutaneous immunization, antigen-specific T cell proliferation and cytokine production in plt mice are increased and remain markedly elevated for at least 8 wk. Compared with wild-type mice, a proportion of T cell response in plt mice are shifted to the spleen, and prior splenectomy reduces the T cell response in draining lymph nodes. After immunization of plt mice, T cells and dendritic cells colocalize in the superficial cortex of lymph nodes and in splenic bridging channels, but not in T cell zones. These results demonstrate that plt mice mount robust T cell responses despite the failure of naive T cells and activated dendritic cells to enter the thymus dependent areas of secondary lymphoid organs.
Controlled on-chip stimulation of quantal catecholamine release from chromaffin cells using photolysis of caged Ca<sup>2+</sup>on transparent indium-tin-oxide microchip electrodes (2007)

Photorelease of caged Ca(2+) is a uniquely powerful tool to study the dynamics of Ca(2+)-triggered exocytosis from individual cells. Using photolithography and other microfabrication techniques, we have developed transparent microchip devices to enable photorelease of caged Ca(2+), together with electrochemical detection of quantal catecholamine secretion from individual cells or cell arrays as a step towards developing high-throughput experimental devices. A 100 nm thick transparent indium-tin-oxide (ITO) film was sputter-deposited onto glass coverslips, which were then patterned into 24 cell-sized working electrodes (approximately 20 microm by 20 microm). We loaded bovine chromaffin cells with acetoxymethyl (AM) ester derivatives of the Ca(2+) cage NP-EGTA and Ca(2+) indicator dye fura-4F, then transferred these cells onto the working ITO electrodes for amperometric recordings. Upon flash photorelease of caged Ca(2+), a uniform rise of [Ca(2+)](i) within the target cell leads to quantal release of oxidizable catecholamines measured amperometrically by the underlying ITO electrode. We observed a burst of amperometric spikes upon rapid elevation of [Ca(2+)](i) and a "priming" effect of sub-stimulatory [Ca(2+)](i) on the response of cells to subsequent [Ca(2+)](i) elevation, similar to previous reports using different techniques. We conclude that UV photolysis of caged Ca(2+) is a suitable stimulation technique for higher-throughput studies of Ca(2+)-dependent exocytosis on transparent electrochemical microelectrode arrays.
Use of Nanosized Catalysts for Transformation of Chloro-Organic Pollutants (2004)

A new method to transform anthropogenic, chloro-organic compounds (COC) by use of nanosized molecular catalysts immobilized in sol-gel matrixes is presented. COC represent a serious threat to soil and groundwater quality. Metalloporphyrinogens are nanometer sized molecules that are known to catalyze degradation of COC by reduction reactions. In the current study, metalloporphyrinogens were immobilized in sol--gel matrixes with pore throat diameters of nanometers. The catalytic activity of the matrix arrays for anaerobic reduction of tetrachloroethylene (PCE), trichloroethylene (TCE), and carbon tetrachloride (CT) was examined. Experiments were performed under conditions pertinent to groundwater systems, with titanium citrate and zero-valent iron as electron donors. All chloroorganic compounds were reduced in the presence of several sol-gel-metalloporphyrinogen hybrids (heterogeneous catalysts). For example, cobalt-5,10,15,20-(4-hydroxyphenyl)-21H,23H-porphine (TP(OH)P-Co) and cyanocobalamin (vitamin B12) reduced CT concentrations to less than 5% of their initial values in a matter of hours. Cyanocobalamin was found to reduce PCE to trace amounts in less than 48 h and TCE to less than 25% of its initial concentration in 144 h. The reactions were compared to their homogeneous (without sol-gel matrix) analogues. The reduction activity of COC for the homogeneous and heterogeneous systems ranged between similar reactivity in some cases to lower reduction rates for the heterogeneous system. These lower rates are, however, compensated by the ability to encapsulate and reuse the catalyst. Experiments with cyanocobalamin showed that the catalyst could be reused over at least 12 successive cycles of 24 h each.
Understanding the role of sentiment analysis in contract risk classification (2014)

This paper describes a novel approach for identifying IT outsourcing contract renewal risk ahead of contract expiration by taking into account not only client satisfaction survey results (in the form of numeric scores), but also client interview transcripts (in the form of unstructured text). By using machine learning techniques, the interview transcripts are automatically processed to identify important topics of interest along with an associated sentiment for each topic. The output of the sentiment analysis is then used as an input (in addition to client satisfaction survey scores) to classify contract renewal risk. We show that, by using sentiment analysis to transform unstructured textual information into structured input, the classification accuracy of non-renewing contracts, in particular, is substantially enhanced. Moreover, the topics with negative sentiments can shed light on the root causes of problems leading to contract non-renewal.
Flexibly Extensible Planar Self-Isolated Wideband MIMO Antenna for 5G Communications (2019)

A planar flexibly extensible multiple-input–multiple-output (MIMO) antenna array with a self-isolation property is proposed. The main characteristics of the proposed array are: (i) no extra isolation structure is required to improve isolation between elements; (ii) elements are arranged with each other with a spacing of 0 mm, (iii) the configuration can be flexibly extended to a large antenna array according to actual requirements. For a test example, the practical processing and testing of an eight-element array is conducted. The tested results demonstrate that the proposed design possesses wide impedance bandwidth (IBW) of 65% and very good isolation (>18 dB) across the operating bandwidth, which match well with the simulated ones. Moreover, envelope correlation coefficient (ECC) is calculated to valuate MIMO performance; an acceptable ECC (lower than 0.05) suggests that the proposed configuration has good diversity performance and can be a potential candidate for MIMO communications.
URTICARIA, DEAFNESS, AND AMYLOIDOSIS: A NEW HEREDO-FAMILIAL SYNDROME (1962)

Journal Article URTICARIA, DEAFNESS, AND AMYLOIDOSIS: A NEW HEREDO-FAMILIAL SYNDROME Get access THOMAS J. MUCKLE, THOMAS J. MUCKLE Derbyshire Royal Infirmary Search for other works by this author on: Oxford Academic PubMed Google Scholar MICHAEL WELLS MICHAEL WELLS Derbyshire Royal Infirmary Search for other works by this author on: Oxford Academic PubMed Google Scholar QJM: An International Journal of Medicine, Volume 31, Issue 2, April 1962, Pages 235–248, https://doi.org/10.1093/oxfordjournals.qjmed.a066967 Published: 01 April 1962 Article history Received: 17 August 1961 Published: 01 April 1962
Waveguide-integrated pin photodiode on InP (1987)

An InGaAs PIN photodiode was vertically integrated with an inverted optical rib waveguide in InGaAsP. Guided light was transferred to and absorbed by the photodiode at a rate of 0.07dB/μm. For detectors with sufficient length (>300μm) a responsivity of 0.81 A/W was achieved at 1.3 μm wave-length.
Head-head interactions in zwitterionic associating polymers (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHead-head interactions in zwitterionic associating polymersJ. L. Bredas, R. R. Chance, and R. SilbeyCite this: Macromolecules 1988, 21, 6, 1633–1639Publication Date (Print):June 1, 1988Publication History Published online1 May 2002Published inissue 1 June 1988https://pubs.acs.org/doi/10.1021/ma00184a019https://doi.org/10.1021/ma00184a019research-articleACS PublicationsRequest reuse permissionsArticle Views396Altmetric-Citations79LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Determination of rotor temperature for an interior permanent magnet synchronous machine using a precise flux observer (2014)

In this paper an enhanced method to determine the rotor temperature of permanent magnet synchronous machines during dynamic operations is presented. The approach is based on a fundamental wave flux observer and is therefore independent of coolant conditions to a large extend. This contribution continues the work presented earlier, where the temperature observer was introduced for steady state operation in exemplary operating points. Hence, an extension to dynamic operation in a wide speed and torque range is proposed. Consequently, the focus now lies on a discrete-time machine modelling as well as on the parameter identification. Measurement results prove the satisfying performance of the observer.