gebhart/patrepeval huggingface dataset:
Toward millions of file system IOPS on low-cost, commodity hardware (2013)

We describe a storage system that removes I/O bottlenecks to achieve more than one million IOPS based on a user-space file abstraction for arrays of commodity SSDs. The file abstraction refactors I/O scheduling and placement for extreme parallelism and non-uniform memory and I/O. The system includes a set-associative, parallel page cache in the user space. We redesign page caching to eliminate CPU overhead and lock-contention in non-uniform memory architecture machines. We evaluate our design on a 32 core NUMA machine with four, eight-core processors. Experiments show that our design delivers 1.23 million 512-byte read IOPS. The page cache realizes the scalable IOPS of Linux asynchronous I/O (AIO) and increases user-perceived I/O performance linearly with cache hit rates. The parallel, set-associative cache matches the cache hit rates of the global Linux page cache under real workloads.
The Impact of Care Coordination on Children With Special Health Care Needs (1994)

Families of children with special health care needs face challenges in securing comprehensive health, educational, and social services. As a result, care may be fragmented, duplicative, confusing, and unnecessarily costly. Case management or care coordination is a method of overcoming some of the obstacles experienced by these children and their families. This article describes the Automated Case Management System/Community Based Care Coordination Project for California Children Services Children and Their Families in Los Angeles County (grant number MCJ 065020), a grant project funded by the Maternal Child Health Bureau from October 1987 to December 1990 in which family-centered, community-based care coordination services were provided to a select group of clients and the effectiveness of the interventions was evaluated. Care coordination was readily accepted by families and resulted in increased services, but the evaluation proved to be challenging.
REVERSIBLE OVULATORY FAILURE ASSOCIATED WITH THE DEVELOPMENT OF LUTEINIZED UNRUPTURED FOLLICLES IN WOMEN WITH INFLAMMATORY ARTHRITIS TAKING NON-STEROIDAL ANTI-INFLAMMATORY DRUGS (1996)

The case histories of three young women with ankylosing spondylitis, rheumatoid arthritis and a seronegative inflammatory polyarthritis undergoing investigations for infertility are presented. In each, non-steroidal anti-inflammatory drug (NSAID) therapy was associated with the recurrent development of luteinized unruptured ovarian follicles and normal ovulation following drug withdrawal. It is suggested that NSAID therapy may be an important and frequently overlooked cause of anovulation and infertility.
Comparative Characterization of Foxtail Millet, Physico-Chemical Approach for its Suitability to Celiacs (2014)

This investigation Focused on comparative physico-chemical characterization of Foxtail millet in the form of pearling and germination and the changes evaluated with raw grains and staple cereals as well. Proximate outcomes showed no marked differences after treatments. These pre-treatments resulted in 58% and 83% reduction in total polyphenols, 43% and 53% reduction in phytic acid for germinated and pearled flour respectively. Calcium, Iron and Zinc content lies at 24.1 mg/g, 4.2227 mg/g and 1.0499 mg/g respectively in germinated grains, which decreased to 18.88 mg/g, 2.5504 mg/g and 0.4635 mg/g after pearling. Observations for comparable antioxidant capacity of bran depict its nutraceutical characteristics. Lowering of peak viscosity value from 46.20 cP for pearled to 4.17 cP for germinated proves its suitability for bakery consideration. Results from the above investigation can be a basis to consume it as staple diet.
Alzheimer's Disease: From Pathology to Therapeutic Approaches (2009)

Mind how you go: The current strategies for the development of therapies for Alzheimer's disease are very diverse. Particular attention is given to the search for inhibitors (see picture for two examples) of the proteolytic enzyme beta- and gamma-secretase, which inhibits the cleavage of the amyloid precursor proteins into amyloid beta peptides, from which the disease-defining deposits of plaque in the brains of Alzheimer's patients originates.Research on senile dementia and Alzheimer's disease covers an extremely broad range of scientific activities. At the recent international meeting of the Alzheimer's Association (ICAD 2008, Chicago) more than 2200 individual scientific contributions were presented. The aim of this Review is to give an overview of the field and to outline its main areas, starting from behavioral abnormalities and visible pathological findings and then focusing on the molecular details of the pathology. The "amyloid hypothesis" of Alzheimer's disease is given particular attention, since the majority of the ongoing therapeutic approaches are based on its theoretical framework.
Forty Hertz EEG Activity in Dementia of the Alzheimer Type and Multi‐Infarct Dementia (1985)

ABSTRACT High frequency EEG activity within the 40 Hz band was examined at rest and during two problem solving tasks in patients with presumptive diagnoses of either dementia of the Alzheimer type (DAT) or Multi‐Infarct Dementia (MID), and in normal elderly subjects. The DAT patients differed significantly from normals and MID subjects, exhibiting both decreased rates of 40 Hz EEG activity and no task‐appropriate pattern of cerebral lateralization. Although MID patients did not differ from controls during baseline, significantly less 40 Hz activity was present during performance of a sentence repetition task. Evidence for normal task‐specific asymmetry was present in the MID and control groups. The results suggest that patterns of 40 Hz EEG activity may be of utility in the early diagnosis of DAT. Further, the 40 Hz rhythm appears able to discriminate between patient populations that present with similar patterns of dementia.
High speed terahertz modulation from metamaterials with embedded high electron mobility transistors (2011)

We present a computational and experimental study of a novel terahertz (THz) device resulting from hybridization of metamaterials with pseudomorphic high electron mobility transistors (HEMTs), fabricated in a commercial gallium arsenide (GaAs) process. Monolithic integration of transistors into each unit cell permits modulation at the metamaterial resonant frequency of 0.46 THz. Characterization is performed using a THz time-domain spectrometer (THz-TDS) and we demonstrate switching values over 30%, and THz modulation at frequencies up to 10 megahertz (MHz). Our results demonstrate the viability of incorporating metamaterials into mature semiconductor technologies and establish a new path toward achieving electrically tunable THz devices.
IMPROVED GAS LIFT PROPOSED FOR HUNGARIAN FIELD (1997)

Changes in parameters such as tubing size, well-head type, and gas lift pressures can improve the profitability of gas-lifted oil wells. As an example, using field data and computer calculations, optimum tubing size and injection pressure were determined for the largest oil field in Hungary, the Algyo field, near Szeged. Most wells in the field are on continuous-flow gas lift designed in the late 1960s with unique features dictated by the economics and technology of those times. Proper operation was maintained until recently, but changes in reservoir parameters because of depletion have led to many unfavorable conditions that have increased lift gas requirements and raised production costs. In this example, the widespread use of wellhead chokes for controlling well production rates are shown to be detrimental. With assumed optimum conditions, total required gas lift volumes are calculated and compared to current quantities. The system modifications proposed by the authors could significantly improve the economics of the Algyo production operations.
Wear Resistance Improvement of Titanium Bearings by Laser Gas Nitriding (2011)

The influence of gas nitriding of commercial pure titanium and Ti-6Al-4V (Ti64) alloy by using a Q-sw laser on the wear loss during rolling contact fatigue is investigated. Despite very good biocompatibility, high strength to weight ratio and corrosion resistance, the tribological properties of titanium alloys are inferior to those of other metal alloys, such as steel. Fretting and wear related aspects become important issues when titanium alloys are used in rolling contact applications. Titanium bearings are employed in applications requiring high strength, light weight, and minimum maintenance (for example, aerospace and defense industries). In this work, a Q-sw laser was used to coat pure commercial titanium and Ti-6Al-4V bearings with TiN in a closed chamber in nitrogen atmosphere. The samples were tested under water by using a thrust-type rolling contact fatigue machine. The microstructure, morphology and crystallographic texture of the layers were observed by laser confocal microscope, scanning electron microscope and electron backscatter diffraction (EBSD). By optimizing the laser processing parameters, such as laser scanning speed, power and beam diameter, thin TiN coats of 1 to 3 m were produced. The wear loss of the coated samples was at least ten times lower than that of the uncoated bearings.
Cyclization of vinyl radicals: a versatile method for the construction of five- and six-membered rings (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCyclization of vinyl radicals: a versatile method for the construction of five- and six-membered ringsG. Stork and Neil H. BaineCite this: J. Am. Chem. Soc. 1982, 104, 8, 2321–2323Publication Date (Print):April 1, 1982Publication History Published online1 May 2002Published inissue 1 April 1982https://pubs.acs.org/doi/10.1021/ja00372a042https://doi.org/10.1021/ja00372a042research-articleACS PublicationsRequest reuse permissionsArticle Views1702Altmetric-Citations168LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Tsg101, a homologue of ubiquitin-conjugating (E2) enzymes, binds the L domain in HIV type 1 Pr55 <sup>Gag</sup> (2001)

Ubiquitination appears to be involved in virus particle release from infected cells. Free ubiquitin (Ub), as well as Ub covalently bound to a small fraction of p6 Gag, is detected in mature HIV particles. Here we report that the p6 region in the Pr55(Gag) structural precursor polyprotein binds to Tsg101, a putative Ub regulator that is involved in trafficking of plasma membrane-associated proteins. Tsg101 was found to interact with Gag in (i) a yeast two-hybrid assay, (ii) in vitro coimmunoprecipitation by using purified Pr55(Gag) and rabbit reticulocyte lysate-synthesized Tsg101, and (iii) in vivo in the cytoplasm of COS cells transfected with gag. The PTAPP motif [or late (L) domain] within p6, which is required for release of mature virus from the plasma membrane, was the determinant for binding Pr55(Gag). The N-terminal region in Tsg101, which is homologous to the Ubc4 class of Ub-conjugating (E2) enzymes, was the determinant of interaction with p6. Mutation of Tyr-110 in Tsg101, present in place of the active-site Cys that binds Ub in E2 enzymes, and other residues unique to Tsg101, impaired p6 interaction, indicating that features that distinguish Tsg101 from active E2 enzymes were important for binding the viral protein. The results link L-domain function in HIV to the Ub machinery and a specific component of the cellular trafficking apparatus.
The emerging neuropathology of essential tremor (2007)

Essential tremor (ET) is one of the most prevalent neurological disorders. At the same time, it is among the most poorly-understood of these disorders. The underlying anatomical pathology of ET has been elusive until recently. Postmortem studies have begun to display some of the underlying brain changes in patients with this disease. These types of investigations are likely to lead the way to additional insights into the pathophysiology of ET and guide the development of therapies for this common movement disorder.
Optical Coherence Tomography: An Introduction to the Technique and its Use (2000)

This report describes the new optical imaging technique of optical coherence tomography (OCT). OCT is capable of high-resolution, micrometer-scale, cross-sectional imaging of biological tissue. The OCT for ophthalmic application uses 843-nm, near-infrared light, which produces a longitudinal resolution of 10 to 20 microm and a penetration depth of a few millimeters. The scans are displayed in a false color representation scale on which warm colors represent areas of high optical reflectivity and cool colors represent areas of minimal or no reflectivity. A cross-sectional view similar to a histology section is obtained. The cornea, iris, and lens may be visualized as well as the retina and optic nerve. OCT has been used to investigate several ocular diseases. These include macular disease, genetic retinal disease, retinal detachment and retinoschisis, choroidal tumors, optic nerve disorders, and glaucoma.
Structural Biology of the Major Facilitator Superfamily Transporters (2015)

The ancient and ubiquitous major facilitator superfamily (MFS) represents the largest secondary transporter family and plays a crucial role in a multitude of physiological processes. MFS proteins transport a broad spectrum of ions and solutes across membranes via facilitated diffusion, symport, or antiport. In recent years, remarkable advances in understanding the structural biology of the MFS transporters have been made. This article reviews the history, classification, and general features of the MFS proteins; summarizes recent structural progress with a focus on the sugar porter family transporters exemplified by GLUT1; and discusses the molecular mechanisms of substrate binding, alternating access, and cotransport coupling.
Nonstabilized Azomethine Ylides Generated by Decarboxylative Condensation of α-Amino Acids. Structural Variation, Reactivity, and Stereoselectivity (1989)

Abstract A variety of aldehydes, containing enolizable aldehydes other than acetaldehyde can be used in the generation method of nonstabilized azomethine ylides by decarboxylative condensation of α-amino acids. Reactivity of the nonstabilized ylides was examined in intermolecular and intramolecular cycloadditions with olefins; stereoselectivity of the intramolecular cycloaddition using nonstabilized ylides was compared with that of ester-stabilized ylides.
Hybrid, elastomeric hydrogels crosslinked by multifunctional block copolymer micelles (2010)

Amphiphlic block copolymers consisting of hydrophilic, poly(acrylic acid) randomly decorated with acrylate groups and hydrophobic, rubbery poly(n-butyl acrylate) self-assembled into well-defined micelles with an average diameter of ~21 nm. Radical polymerization of acrylamide in the presence of the crosslinkable micelles gave rise to hybrid, elastomeric hydrogels whose mechancial properties can be readily tuned by varying the BCM concentration.
Occlusion detection of real objects using contour based stereo matching (2005)

In Augmented Reality, the occlusion between virtual and real objects has to be managed correctly, so that users can look at the natural scene. In order to overcome this problem, the depth of the real world from the user's viewpoint is employed. However, if the system is used in an environment including moving or deformable objects, the depth has to be measured in real-time. In this paper, we propose a method for real-time stereo matching using a contour based approach to acquire the accurate depth of the boundary of real objects.
Inhibition of Wnt/β‐<scp>C</scp>atenin Signaling Promotes Engraftment of Mesenchymal Stem Cells to Repair Lung Injury (2013)

We sought to explore the treatment effects and the repair mechanisms of bone marrow derived mesenchymal stem cells (MSCs) during HCl-induced acute lung injury (ALI). MSCs were delivered through the tail veins of rats 24 h after intranasal instillation of HCl. The results showed that MSCs did not ameliorate the histopathologic changes of ALI and pulmonary fibrosis. We found that the activated Wnt/β-catenin signaling may regulate the differentiation of MSCs and is associated with lung fibroblasts activation, pulmonary fibrosis and tissue repair process in ALI rats. Immunofluorescence and histology analysis indicated that activated canonical Wnt/β-catenin signaling induced most MSCs to differentiate into myofibroblasts or fibroblasts in vivo. However, inhibition of Wnt/β-catenin signaling by Dickkopf-1 (DKK1) promotes epithelial differentiation of MSCs induced by native alveolar epithelial cells which are beneficial to repair the injured lung epithelium. Inhibition of Wnt/β-catenin signaling after MSCs transplantation ameliorated pulmonary fibrosis and improved pulmonary function which attenuated the lung injury. In vitro study, activation of the Wnt/β-catenin signaling stimulated MSCs to express myofibroblasts markers, which was attenuated by DKK1. Furthermore, Wnt3α activated Wnt/β-catenin signaling in lung fibroblasts to enhance the expression of collagen I, vimentin and α-smooth muscle actin, but DKK1 attenuated these proteins expression. These findings demonstrated that canonical Wnt/β-catenin signaling plays a key role in regulating differentiation of MSCs in vivo or in vitro and the pathogenesis of fibrotic diseases. Our study suggested that inhibition of abnormal activated Wnt/β-catenin signaling would promote MSCs epithelial differentiation to repair lung injury and reduce pulmonary fibrosis.
Delirium as a predictor of long-term cognitive impairment in survivors of critical illness (2010)

In this study of mechanically ventilated medical intensive care unit patients, duration of delirium (which is potentially modifiable) was independently associated with long-term cognitive impairment, a common public health problem among intensive care unit survivors.
Thienopyrazine-based low-bandgap polymers for flexible polymer solar cells (2010)

The optical gaps of the low-bandgap PPVs (PM-20, PM-19, PM-18) are decreased down to 1.6-1.7 eV compared with that of MDMO-PPV (2.2 eV). The best lateral hole mobility was determined to be 2.1 × 10-3 cm2/V s (PM-18) in field effect transistors and exceeds that of MDMO-PPV (poly-[ 2-methoxy-5-(3'.7'-dimethyloctyloxy)-1.4-phenylenevinylene], 8.5 × 10-4 cm2/V s). This allows to reduce the PCBM ([6.6]-phenyl-C-butanoic acid methyl ester) content in solar cell devices down to 1:2 w/w giving a better than for MDMO-PPV:[60]-PCBM cells (PM-19:[60]-PCBM 2.32% on ITO-PET, 2.86% on ITO glass). The charge transfer to PCBM as acceptor occurs quite normally and shows an effective charge separation using light-induced spin resonance spectroscopy (LESR). The [70]-PCBM signals are shifted to lower field related to those of [60]-PCBM and overlap more with the polaron signal of PM-19. The LESR g-factor components of [70]-PCBM are reported for the first time. The external quantum efficiency peak values achieve up to 42% at ~350–400 nm and 26% at ~640 nm (PM-19:[60]-PCBM).
Forced vital capacity, airway obstruction and survival in a general population sample from the USA (2010)

FVC but not airway obstruction predicts survival in asymptomatic adults without chronic respiratory diagnoses or persistent respiratory symptoms. The association is not explained by age, anthropometry, smoking, income occupation or blood pressure. As FVC later in life, cardiovascular risk, type II diabetes mellitus and low-grade systemic inflammation are all associated with poor fetal growth, these other conditions may be partly responsible for the poor survival in those with low FVC.
An empirical study of latency in an emerging class of edge computing applications for wearable cognitive assistance (2017)

An emerging class of interactive wearable cognitive assistance applications is poised to become one of the key demonstrators of edge computing infrastructure. In this paper, we design seven such applications and evaluate their performance in terms of latency across a range of edge computing configurations, mobile hardware, and wireless networks, including 4G LTE. We also devise a novel multi-algorithm approach that leverages temporal locality to reduce end-to-end latency by 60% to 70%, without sacrificing accuracy. Finally, we derive target latencies for our applications, and show that edge computing is crucial to meeting these targets.
Multiplatform Mass Spectrometry-Based Approach Identifies Extracellular Glycolipids of the Yeast <i>Rhodotorula babjevae</i> UCDFST 04-877 (2016)

A multiplatform mass spectrometry-based approach was used for elucidating extracellular lipids with biosurfactant properties produced by the oleaginous yeast Rhodotorula babjevae UCDFST 04-877. This strain secreted 8.6 ± 0.1 g/L extracellular lipids when grown in a benchtop bioreactor fed with 100 g/L glucose in medium without addition of hydrophobic substrate, such as oleic acid. Untargeted reversed-phase liquid chromatography-quadrupole/time-of-flight mass spectrometry (QTOFMS) detected native glycolipid molecules with masses of 574-716 Da. After hydrolysis into the fatty acid and sugar components and hydrophilic interaction chromatography-QTOFMS analysis, the extracellular lipids were found to consist of hydroxy fatty acids and sugar alcohols. Derivatization and chiral separation gas chromatography-mass spectrometry (GC-MS) identified these components as d-arabitol, d-mannitol, (R)-3-hydroxymyristate, (R)-3-hydroxypalmitate, and (R)-3-hydroxystearate. In order to assemble these substructures back into intact glycolipids that were detected in the initial screen, potential structures were in-silico acetylated to match the observed molar masses and subsequently characterized by matching predicted and observed MS/MS fragmentation using the Mass Frontier software program. Eleven species of acetylated sugar alcohol esters of hydroxy fatty acids were characterized for this yeast strain.
Efficient phase conjugation by pico-second four-wave-mixing in solid-dye amplifier (2004)

We demonstrate 2.5 times phase conjugation by four-wave-mixing with the use of pico-second pulses in a rhodamine6G dye polymer amplifier. Phase conjugation pulse shortening by a factor of 2 is also measured.
Intermittent vs Continuous Androgen Deprivation Therapy for Prostate Cancer (2015)

Intermittent androgen deprivation was not inferior to continuous therapy with respect to the overall survival. Some quality-of-life criteria seemed improved with intermittent therapy. Intermittent androgen deprivation can be considered as an alternative option in patients with recurrent or metastatic prostate cancer.