gebhart/patrepeval huggingface dataset:
A phenomenological model for the responses of auditory-nerve fibers. II. Nonlinear tuning with a frequency glide (2003)

A computational model was developed to simulate the responses of auditory-nerve (AN) fibers in cat. The model's signal path consisted of a time-varying bandpass filter; the bandwidth and gain of the signal path were controlled by a nonlinear feed-forward control path. This model produced realistic response features to several stimuli, including pure tones, two-tone combinations, wideband noise, and clicks. Instantaneous frequency glides in the reverse-correlation (revcor) function of the model's response to broadband noise were achieved by carefully restricting the locations of the poles and zeros of the bandpass filter. The pole locations were continuously varied as a function of time by the control signal to change the gain and bandwidth of the signal path, but the instantaneous frequency profile in the revcor function was independent of sound pressure level, consistent with physiological data. In addition, this model has other important properties, such as nonlinear compression, two-tone suppression, and reasonable Q10 values for tuning curves. The incorporation of both the level-independent frequency glide and the level-dependent compressive nonlinearity into a phenomenological model for the AN was the primary focus of this work. The ability of this model to process arbitrary sound inputs makes it a useful tool for studying peripheral auditory processing.
Motion of Gold Atoms on Carbon in the Aberration-Corrected STEM (2007)

The movement of heavy atoms on a thin carbon substrate is readily observed using a sub-Angstrom electron probe. The observed movement is consistent with an electron beam activation mechanism whereby atoms are occasionally detached from bonding sites, allowing rapid diffusion to new sites that may be quite far from the original. The bonding sites are most often observed to lie at defects, steps, and other asperities in the substrate. Formation of three-dimensional clusters can occur during diffusion of several isolated atoms. Coalescence and dissolution of larger clusters and islands both occur under varying observation conditions, but island coalescence appears most probable for islands that are greater than 2 nm in size.
Development of Antiviral Agents for the Treatrrient of Human Immunodeficiency Virus Infection (1988)

Antiviral agents under investigation for the treatment of patients infected with the human immunodeficiency virus (HIV) are reviewed. Multiple mechanisms exist by which antiviral agents might inhibit the replication of HIV or eradicate its latent form in affected cells, or both. These mechanisms include (1) interference with the cell surface receptor for HIV, (2) prevention of uncoating of viral particles, (3) inhibition of reverse transcriptase, (4) prevention of integration and posttranscription processing, (5) interference with viral assembly, and (6) interference with virus release. Most agents developed thus far work by inhibiting HIV reverse transcriptase. Suramin, ribavirin, ammonium 21-tungsten-9-antimoniate (HPA-23), foscarnet (phosphonoformate, PFA), inosine pranobex (isoprinosine), peptide T, ampligen, AL 721, dideoxycytidine, and zidovudine (formerly azidothymidine) have antiretroviral activity in vitro. To date zidovudine is the only antiretroviral agent approved by the FDA as clinically effective. However, zidovudine has serious toxicities, including neutropenia and anemia; in some patients dosage reduction or cessation of therapy may be necessary. Because treatment with zidovudine does not cure HIV infection, numerous studies are under way with other anti-HIV agents. Ultimately, combinations of agents probably will be used to suppress or eradicate HIV. While the search for more efficacious and less toxic treatments continues, the development of zidovudine in such a short time provides hope that progress toward a cure will be made rapidly.
Heteroepitaxial growth of Ge films on Si substrates by molecular beam epitaxy (1988)

A new approach of growing thick Ge layers on Si substrates by molecular beam epitaxy is presented. A 30–80 Å thick Ge overlayer is first deposited on the Si(100) substrate at room temperature. By thermally annealing the sample to 300 or 500 °C for 10 min, the Ge atoms cluster into randomly distributed islands which would play a role in releasing the mismatch stress at the interface. The Ge film of 10 000 Å thickness epitaxially grown on this surface at 550 °C shows a better crystalline quality than that grown by a conventional method. A full width at half maximum of 262 s for the Ge (400) x-ray diffraction peak has been achieved.
Continuous Flow Reduction of Artemisinic Acid Utilizing Multi‐Injection Strategies—Closing the Gap Towards a Fully Continuous Synthesis of Antimalarial Drugs (2015)

One of the rare alternative reagents for the reduction of carbon-carbon double bonds is diimide (HN=NH), which can be generated in situ from hydrazine hydrate (N2H4⋅H2O) and O2. Although this selective method is extremely clean and powerful, it is rarely used, as the rate-determining oxidation of hydrazine in the absence of a catalyst is relatively slow using conventional batch protocols. A continuous high-temperature/high-pressure methodology dramatically enhances the initial oxidation step, at the same time allowing for a safe and scalable processing of the hazardous reaction mixture. Simple alkenes can be selectively reduced within 10-20 min at 100-120 °C and 20 bar O2 pressure. The development of a multi-injection reactor platform for the periodic addition of N2H4⋅H2O enables the reduction of less reactive olefins even at lower reaction temperatures. This concept was utilized for the highly selective reduction of artemisinic acid to dihydroartemisinic acid, the precursor molecule for the semisynthesis of the antimalarial drug artemisinin. The industrially relevant reduction was achieved by using four consecutive liquid feeds (of N2H4⋅H2O) and residence time units resulting in a highly selective reduction within approximately 40 min at 60 °C and 20 bar O2 pressure, providing dihydroartemisinic acid in ≥93% yield and ≥95% selectivity.
<title>Moving-target SAR/ISAR imaging using the ImSyn processor</title> (1996)

The ImSyn<SUP>TM</SUP> Processor is an optoelectronic device developed by Essex Corporation to accelerate the SAR imaging process. This paper focuses on the application of the ImSyn Processor to SAR/ISAR imaging of moving targets from a moving platform. The targets may have non-uniform translational and rotational motion during the data collection process. The ImSyn processor operates directly on the polar frequency data permitting interaction with the SAR phase history without data interpolation. The process produces high quality sub-aperture images for determining the phase errors, which enables the implementation of motion compensation and autofocus algorithms. Simulations and examples of SAR/ISAR images from the prototype system for both stationary and moving targets are presented.
Characterization and expression of a cloned tetracycline resistance determinant from Campylobacter jejuni plasmid pUA466 (1987)

A tetracycline resistance (Tcr) determinant previously cloned from the Campylobacter jejuni plasmid pUA466 (D. E. Taylor, J. Bacteriol. 165:1037-1039, 1986) was localized by restriction endonuclease mapping, subcloning, and Tn1000 insertion mutagenesis to a 2-kilobase region consisting of 1.8- and 0.2-kilobase HincII fragments. Tcr encoded by the cloned fragment (pUOA1) was expressed constitutively in Escherichia coli. A protein with an apparent molecular weight of 68,000 encoded by pUOA1 was produced in an in vitro transcription-translation system and in minicells. Tn1000 insertions which resulted in inactivation of Tcr expression also resulted in an alteration in the 68,000-molecular-weight protein. Some mutants specified a truncated protein, whereas others completely lost the ability to specify the protein. The protein which appears to be involved in the expression of Tcr specified by C. jejuni plasmids is of approximately the same molecular weight as the protein specified by the streptococcal class M determinant. This finding is consistent with our previous results which indicate that homology exists between the Tcr determinant from C. jejuni and a 5-kilobase HincII probe derived from the streptococcal class M determinant.
Improving the Performance of Polyfluorene-Based Organic Light-Emitting Diodes via End-capping (2001)

Efficient deep-blue electroluminescence(EL) is obtained via end-capping polyfluorene (PF) homopolymers with hole-transporting moieties (HTMs). Strong evidence that the observed improvement in device performance is related to the end-capper moieties comes from the comparison of two different end-cappers. The HTM does not disturb the liquid-crystal properties of the PF polymer. Using doped polyimide alignment layers, polarized light-emitting diodes (LEDs) with a polarization ratio in excess of twenty at an efficiency of 0.25 cd/A could be realized.
Spectroelectrochemistry and electrochemical preparation method of Prussian blue modified electrodes (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSpectroelectrochemistry and electrochemical preparation method of Prussian blue modified electrodesKingo Itaya, Tatsuaki Ataka, and Shinobu ToshimaCite this: J. Am. Chem. Soc. 1982, 104, 18, 4767–4772Publication Date (Print):September 1, 1982Publication History Published online1 May 2002Published inissue 1 September 1982https://pubs.acs.org/doi/10.1021/ja00382a006https://doi.org/10.1021/ja00382a006research-articleACS PublicationsRequest reuse permissionsArticle Views4808Altmetric-Citations562LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Providing K-Anonymity in location based services (2010)

The offering of anonymity in relational databases has attracted a great deal of attention in the database community during the last decade [4]. Among the different solution approaches that have been proposed to tackle this problem, K-anonymity has received increased attention and has been extensively studied in various forms. New forms of data that come into existence, like location data capturing user movement, pave the way for the offering of cutting edge services such as the prevailing Location Based Services (LBSs). Given that these services assume an in-depth knowledge of the mobile users' whereabouts it is certain that the assumed knowledge may breach the privacy of the users. Thus, concrete approaches are necessary to preserve the anonymity of the mobile users when requesting LBSs. In this work, we survey recent advancements for the offering of K-anonymity in LBSs. Most of the approaches that have been proposed heavily depend on a trusted server component -- that acts as an intermediate between the end user and the service provider - to preserve the anonymity of the former entity. Existing approaches are partitioned in three categories: (a) historical K-anonymity, (b) location K-anonymity, and (c) trajectory K-anonymity. In each of these categories we present some of the most prevalentmethodologies that have been proposed and highlight their operation.
The microbial degradation of morpholine (1982)

Morpholine can be completely degraded microbiologically, and two organisms have been isolated, each capable of growth in a simple mineral salts medium with morpholine as the sole source of carbon, nitrogen and energy. Excess nitrogen is liberated as ammonia. The enzymes responsible for the oxidation of morpholine are inducible and, in organism Mor G, will also oxidize piperidine, piperazine and pyrrolidine, which are not growth substrates. Ethanolamine is a likely intermediate, though the metabolic steps in morpholine degradation do not give rise solely to acetyl‐CoA. After a period of acclimation, a laboratory scale activated sludge plant effectively removed morpholine over the long period it was operated; the sludge was also capable of nitrification. The possible effects of other chemicals in trade wastes containing morpholine on nitrification and morpholine oxidation are described.
FastFISH: technique for ultrarapid fluorescence in situ hybridization on uncultured amniocytes yielding results within 2 h of amniocentesis (2007)

Rapid aneuploidy detection methods allow prenatal diagnosis results to be released within 48 h, but not on the same day as the invasive test. We aimed to develop a rapid fluorescence in situ hybridization (FISH) method (FastFISH) that releases accurate results on the same day as amniocentesis. FastFISH was optimized to be completed within 2 h of sample collection using CEP and LSI probes for chromosomes 13, 18, 21, X, Y and DiGeorge syndrome (DGS). The technique was tested on 100 consecutive amniotic fluid samples in a blinded study. It was also validated as a 1-day molecular genetic test on three representative fetal tissue samples: chorionic villus, amniotic fluid and fetal blood. In the blinded study, FastFISH results were ready within 2 h of sample collection. Of the 100 amniotic fluid samples, 49 male and 50 female fetuses were identified. One fetus was 47, XXY (Klinefelter syndrome). Three fetuses had trisomy 21. One fetus suspected of DGS by ultrasound was identified as normal. Results of FastFISH analyses in all 100 cases were concordant with their karyotypes (100% accuracy; lower 95% CI, 97.05%). In the 1-day test validation, all results were released on the same day and were concordant with their respective karyotypes. FastFISH allows results to be released on the same day as amniocentesis. It represents the necessary development for a 1-day prenatal diagnosis service.
Effect of Interdental Flossing on the Incidence of Proximal Caries in Children (1977)

A clinical study was designed to evaluate the effect of frequent interdental flossing on the incidence of proximal dental caries. School children from a fluoride-deficient area were studied after clinical and radiographic examinations. Each child had at least one contralateral pair of intact, contacting proximal tooth surfaces between the distal surface of the primary cuspid and the mesial surface of the first permanent molar. Randomly selected test surfaces were flossed each school day with unwaxed dental floss by researchers. The contralateral surfaces served as controls. Flossing was done for eight months, discontinued for four months, and reinstituted for another eight months. A significant reduction in the incidence of proximal caries resulted.
Protective Effects of Moderate Hypothermia on Behavioral Deficits But Not Necrotic Cavitation Following Cortical Impact Injury in the Rat (1998)

A number of experimental studies have reported that moderate hypothermia can produce significant protection against behavioral deficits and/or morphopathological alterations following traumatic brain injury; a Phase 3 clinical trial is currently examining the therapeutic potential for moderate hypothermia (32 degrees C) to improve outcome following severe traumatic brain injury in humans. The current study examined whether hypothermia (32 degrees C) provided behavioral protection following experimental cortical impact injury. The extent of focal cortical contusion was also examined in the same rats. A total of 30 male Sprague-Dawley rats were trained on beam balance and beam walking tasks prior to injury. Under isoflurane anesthesia, cortical impact was produced on the right parietal cortex of 20 rats. Ten rats underwent all surgical procedures but were not impacted (sham-injured rats). Ten of the injured rats were cooled to 32 degrees C (measured in temporalis muscle) beginning 5 min postinjury, maintained for 2 h and rewarmed slowly for 1 h. In the other 10 injured rats, normothermic temperatures (37.5 degrees C) were maintained for the same duration. Beam balance and beam walking performance was assessed daily for 5 days following injury. At 11 days postinjury, rats were assessed for 5 days on acquisition of the Morris water maze task. Following behavioral assessments, rats were perfused and the brain removed. Coronal sections were cut through the site of cortical impact injury and stained with hematoxylin and eosin. Hypothermic treatment resulted in significantly less beam balance and beam walking deficits than observed in normothermic rats. Hypothermia also significantly attenuated spatial memory performance deficits. Quantitative morphometric analyses failed to detect any significant differences in volumes of necrotic tissue cavitation in cortices of hypothermic and normothermic rats. Hypothermic treatment also had no effect on volumes of dorsal hippocampal tissue or numbers of cells in CA1 or CA3 regions of the hippocampus. These data suggest that hypothermia, consistent with the reports of others, can produce significant behavioral protection following cortical impact injury that is not necessarily correlated with changes in focal cortical necrosis within the first 15 days following injury.
Medical ultrasound algorithm for noninvasive high intensity ultrasound applications (2001)

Thesis (Ph. D.)--University of Washington, 2001
Induction of SOS functions by alkaline intracellular pH in Escherichia coli (1986)

Alkalinization of intracellular pH (pHi) causes an increase in UV resistance in wild-type and pH-sensitive mutant (DZ3) cells of Escherichia coli. Utilizing cells transformed with a plasmid (pA7) which bears the uvrA promoter fused to galK galactokinase structural gene, it was shown that alkaline pHi leads to an increase in the specific activity of galactokinase. This effect was not displayed in a mutant bearing a recA-insensitive lexA gene, nor in cells harboring a plasmid (pA8) in which the galK is fused to a lexA-insensitive uvrA promoter. Hence, the effects of pHi on cells functions may involve the lexA product of the SOS system.
Stochastic-flash analog-to-digital conversion (1998)

Flash-type analog-to-digital converters (ADC's) presenting a nonlinear behavior, i.e., having nonequally spaced threshold levels, may introduce harmonic distortion that can be reduced by employing large-amplitude dither-based conversion techniques. However, large-scale dithering is difficult to implement and, in addition, severely reduces the ADC input dynamic range. In this paper, a new ADC architecture is presented based on ordinary flash conversion and dynamic element matching, that strongly reduces nonlinear distortion. It eliminates the need for large-scale dither signals by randomizing the resistor positions in the resistor string used to generate the voltage references. Some properties of this architecture are analyzed and simulation results that validate the theoretical assumptions are presented.
Gait Analysis Using Floor Markers and Inertial Sensors (2012)

In this paper, a gait analysis system which estimates step length and foot angles is proposed. A measurement unit, which consists of a camera and inertial sensors, is installed on a shoe. When the foot touches the floor, markers are recognized by the camera to obtain the current position and attitude. A simple planar marker with 4,096 different codes is used. These markers printed on paper are placed on the floor. When the foot is moving off the floor, the position and attitude are estimated using an inertial navigation algorithm. For accurate estimation, a smoother is proposed, where vision information and inertial sensor data are combined. Through experiments, it is shown that the proposed system can both track foot motion and estimate step length.
RecA-mediated cleavage activates UmuD for mutagenesis: mechanistic relationship between transcriptional derepression and posttranslational activation. (1988)

The products of the SOS-regulated umuDC operon are required for most UV and chemical mutagenesis in Escherichia coli. It has been shown that the UmuD protein shares homology with LexA, the repressor of the SOS genes. In this paper we describe a series of genetic experiments that indicate that the purpose of RecA-mediated cleavage of UmuD at its bond between Cys-24 and Gly-25 is to activate UmuD for its role in mutagenesis and that the COOH-terminal fragment of UmuD is necessary and sufficient for the role of UmuD in UV mutagenesis. Other genetic experiments are presented that (i) support the hypothesis that the primary role of Ser-60 in UmuD function is to act as a nucleophile in the RecA-mediated cleavage reaction and (ii) raise the possibility that RecA has a third role in UV mutagenesis besides mediating the cleavage of LexA and UmuD.
Enhanced Electron Injection into Inverted Polymer Light‐Emitting Diodes by Combined Solution‐Processed Zinc Oxide/Polyethylenimine Interlayers (2014)

Inverted device architectures for organic light-emitting diodes (OLEDs) require suitable interfaces or buffer layers to enhance electron injection from highwork-function transparent electrodes. A solution-processable combination of ZnO and PEI is reported, that facilitates electron injection and enables efficient and air-stable inverted devices. Replacing the metal anode by highly conductive polymers enables transparent OLEDs.
Positional cloning and characterization of the human aniridia and murine small eye genes (1991)

Aniridia (AN) is a congenital, panocular disorder of the eye characterized by the complete or partial absence of the iris. The disease can occur in both the sporadic and familial forms which, in the latter case, is inherited as an autosomal dominant trait with high penetrance. The objective of this study was to isolate and characterize the genes involved in AN and Sey, and thereby to gain a better understanding of the molecular basis of the two disorders. Using a positional cloning strategy, I have approached and cloned from the AN locus in human chromosomal band 11p13 a cDNA that is deleted in two patients with AN. The deletions in these patients overlap by about 70 kb and encompass the 3$\sp\prime$ end of the cDNA. This cDNA detects a 2.7 kb mRNA encoded by a transcription unit estimated to span approximately 50 kb of genomic DNA. The message is specifically expressed in all tissues affected in all forms of AN, namely within the presumptive iris, lens, neuroretina, the superficial layers of the cornea, the olfactory bulbs, and the cerebellum. Sequence analysis of the AN cDNA revealed a number of motifs characteristic of certain transcription factors. Chief among these are the presence of the paired domain, the homeodomain, and a carboxy-terminal domain rich in serine, threonine and proline residues. The overall structure shows high homology to the Drosophila segmentation gene paired and members of the murine Pax family of developmental control genes. Utilizing a conserved human genomic DNA sequence as probe, I was able to isolate an embryonic murine cDNA which is over 92% homologous in nucleotide sequence and virtually identical at the amino acid level to the human AN cDNA. The expression pattern of the murine gene is the same as that in man, supporting the conclusion that it probably corresponds to the Sey gene. Its specific expression in the neuroectodermal component of the eye, in glioblastomas, but not in the neural crest-derived PC12 pheochromocytoma cell line, suggests that a defect in neuroectodermal rather mesodermal development might be the common etiological factor underlying AN and Sey.