gebhart/patrepeval huggingface dataset:
Tumorigenic Transformation of Immortalized ECV Endothelial Cells by Cyclooxygenase-1 Overexpression (1997)

The cyclooxygenase (Cox) enzyme catalyzes the rate-limiting oxidative and peroxidative enzymatic steps in the biosynthesis of prostanoids. Both Cox-1 and -2 genes encode the two isoenzymes that carry out similar enzymatic steps. Enhanced Cox activity is associated with proliferative diseases such as colon cancer. To determine if a cause and effect relationship exists between Cox isoenzyme overexpression and tumorigenesis, the human Cox-1 and Cox-2 isoenzymes were transfected into ECV immortalized endothelial cells. Although numerous clones of Cox-1 expressing cells were obtained, Cox-2 overexpression resulted in growth disadvantage and increased cell death. In contrast, Cox-1 overexpressing cells expressed high levels of the functional Cox-1 polypeptide in the endoplasmic reticulum and the nucleus. In vitro proliferation of these cells was reduced compared with vector-transfected ECV cells. Cox-1 overexpression also enhanced the tumor necrosis factor-alpha-induced apoptosis of ECV cells 2-fold. In contrast to the in vitro behavior, ECV-Cox-1 cells proliferated aggressively and formed tumors in athymic "nude" mice, whereas the vector-transfected counterparts did not. The growth of Cox-1-induced tumors was not inhibited by indomethacin, suggesting a nonprostanoid function of Cox-1. ECV-Cox-1-derived tumors were angiosarcoma-like and contained numerous host-derived neovessels. These data suggest that Cox-1 overexpression in immortalized ECV endothelial cells results in nuclear localization of the polypeptide and tumorigenesis.
Melt processible fluoropolymers : the definitive user's guide and databook (2003)

This is the second of a two volume series of books about fluoroplastics. Volume 1 covers the non-melt processible homopolymers, requiring non-traditional processing techniques. Volume 2 is devoted to the melt-processible fluoropolymers, their polymerization and fabrication techniques including injection molding, wire, tube, and film extrusion, rotational molding, blow molding, compression molding, and transfer molding. Both a source of data and a reference, the properties, characteristics, applications, safety, disposal, and recycling of melt-processible fluoropolymers are comprehensively detailed for immediate use by today's practicing engineering and scientists in the plastics industry. Students will benefit from the book's arrangement and extensive references.
Construction of Substituted Cyclohexanones by Reductive Cyclization of 7-Oxo-2,8-alkadienyl Esters (2001)

[reaction: see text] Cyclization of 7-oxo-2,8-alkadienyl esters upon reaction with triphenylphosphinecopper hydride hexamer stereoselectively yields substituted cyclohexanones having a cis relationship of carbon side chains at C2 and C3. This cyclohexanone construction is particularly useful for preparing 4-alkoxy- or 4-siloxy-2,3-disubstituted cyclohexanones, in which instance stereoselection is > or = 20:1.
Stock Prices, Earnings, and Expected Dividends (2009)

Long historical averages of real earnings help forecast present values of future real dividends. With aggregate U.S. stock market data (1871-1986), a vector-autoregressive forecast of the present value of future dividends is, for each year, roughly a weighted average of moving-average earnings and current real price, with between two thirds and three fourths of the weight on the earnings measure. We develop the implications of this for the present-value model of stock prices and for recent results that long-horizon stock returns are highly forecastable.
The Relationship Between Marital Status and Health (2003)

Based on census materials collected in Britain from 1921 to 1991 and using bed occupancy as a proxy for health, this study focuses on the relationship between marriage and physical health. The results confirm the positive association between marriage and physical health within this society. Married people consistently make less use of residential health and social care facilities than do nonmarried people, and this relationship holds across all census years. This is not to deny, however, some important health differences within the nonmarried population, such as the increasing vulnerability of widowed females aged 65 years and older and of never-married males of working age.
Primary structure and expression of a pathogen-induced protease (PR-P69) in tomato plants: Similarity of functional domains to subtilisin-like endoproteases. (1996)

A 69-kDa proteinase (P69), a member of the pathogenesis-related proteins, is induced and accumulates in tomato (Lycopersicon esculentum) plants as a consequence of pathogen attack. We have used the polymerase chain reaction to identify and clone a cDNA from tomato plants that represent the pathogenesis-related P69 proteinase. The nucleotide sequence analysis revealed that P69 is synthesized in a preproenzyme form, a 745-amino acid polypeptide with a 22-amino acid signal peptide, a 92-amino acid propolypeptide, and a 631-amino acid mature polypeptide. Within the mature region the most salient feature was the presence of domains homologous to the subtilisin serine protease family. The amino acid sequences surrounding Asp-146, His-203, and Ser-532 of P69 are closely related to the catalytic sites (catalytic triad) of the subtilisin-like proteases. Northern blot analysis revealed that the 2.4-kb P69 mRNA accumulates abundantly in leaves and stem tissues from viroid-infected plants, whereas the mRNA levels in tissues from healthy plants were undetectable. Our results indicate that P69, a secreted calcium-activated endopeptidase, is a plant pathogenesis-related subtilisin-like proteinase that may collaborate with other defensive proteins in a general mechanism of active defense against attacking pathogens.
B cell stimulatory factor 1 (interleukin 4) is a potent costimulant for normal resting T lymphocytes. (1987)

Resting T cells proliferate in response to B cell stimulatory factor 1 (BSF-1; interleukin 4) plus phorbol myristate acetate (PMA). This response is obtained with highly purified T cells and is density independent, suggesting that accessory cells are not required. Both L3T4+ and Lyt-2+ T cells respond to BSF-1 plus PMA. Although BSF-1 alone does not cause T cell proliferation, it maintains the viability of small, dense T cells, indicating that it acts on resting T cells. Furthermore, BSF-1 is required early in the proliferative response of resting T cells to BSF-1 plus PMA, further supporting the concept that it acts on G0 or early G1 cells. However, BSF-1 is also needed late in the first round of division of T cells stimulated with BSF-1 plus PMA. Removing BSF-1 at 24 h of stimulation prevents entry into S phase. These results indicate that BSF-1 is involved in both the induction of competence and in the progression phases of T cell division.
Mouvements de réorientation par effet tunnel des centres V- et VLi dans MgO aux températures de l'hélium liquide (1976)

Nous montrons, par des expériences de Résonance Paramagnétique Electronique sous contrainte uniaxiale et sous champ électrique et par des expériences de Double Résonance Electronique-Electronique (ELDOR) que les centres à trou piégé V- et Vlithium dans MgO se réorientent aux températures de l'hélium liquide. Les moments dipolaires élastique et électrique du centre V- , mesurés à 77 K, sont respectivement : La variation en fonction de la température du temps de réorientation du centre V-, 25 ± 5 ms à 4,2 K et 60 ± 10 ms à 2,1 K, indique que le processus de réorientation est un processus d'effet tunnel assisté par un phonon.
Bridging Adversarial Robustness and Gradient Interpretability (2019)

Adversarial training is a training scheme designed to counter adversarial attacks by augmenting the training dataset with adversarial examples. Surprisingly, several studies have observed that loss gradients from adversarially trained DNNs are visually more interpretable than those from standard DNNs. Although this phenomenon is interesting, there are only few works that have offered an explanation. In this paper, we attempted to bridge this gap between adversarial robustness and gradient interpretability. To this end, we identified that loss gradients from adversarially trained DNNs align better with human perception because adversarial training restricts gradients closer to the image manifold. We then demonstrated that adversarial training causes loss gradients to be quantitatively meaningful. Finally, we showed that under the adversarial training framework, there exists an empirical trade-off between test accuracy and loss gradient interpretability and proposed two potential approaches to resolving this trade-off.
Design of a rotational hydro-elastic actuator for an active upper-extremity rehabilitation exoskeleton (2008)

Our new Limpact exoskeleton is mechanically based on the design of the passive Dampace and will be powered by rotational hydro-elastic actuators (rHEAs), using impedance control. In this paper we describe the design of the rHEA, which is a novel, custom-designed combination of a rotational hydraulic actuator and a symmetric torsion spring. The rHEA can also be used as a springless hydraulic actuator for stiffer admittance control, or for isometric large-torque measurements of up to 100 Nm, by locking specific components in the design.
A feasibility study for the removal of copper from solid ferrous scrap (1991)

A new approach for the removal of copper from solid ferrous scrap is described. With this proposal, solid ferrous scrap intermingled with copper is brought into contact with molten aluminium, which preferentially dissolves copper. After a duration of 5 to 10 minutes at a temperature of 1018 ± 5 K, steel scrap is removed from the bath, resulting in being free of copper contamination. The present method offers the advantage of far lower costs than any other processes ever suggested for copper removal.
Sub-10-nm nanolithography with a scanning helium beam (2009)

Scanning helium ion beam lithography is presented as a promising pattern definition technique for dense sub-10-nm structures. The powerful performance in terms of high resolution, high sensitivity, and a low proximity effect is demonstrated in a hydrogen silsesquioxane resist.
Wetting and phase separation in soft adhesion (2015)

In the classic theory of solid adhesion, surface energy drives deformation to increase contact area whereas bulk elasticity opposes it. Recently, solid surface stress has been shown also to play an important role in opposing deformation of soft materials. This suggests that the contact line in soft adhesion should mimic that of a liquid droplet, with a contact angle determined by surface tensions. Consistent with this hypothesis, we observe a contact angle of a soft silicone substrate on rigid silica spheres that depends on the surface functionalization but not the sphere size. However, to satisfy this wetting condition without a divergent elastic stress, the gel phase separates from its solvent near the contact line. This creates a four-phase contact zone with two additional contact lines hidden below the surface of the substrate. Whereas the geometries of these contact lines are independent of the size of the sphere, the volume of the phase-separated region is not, but rather depends on the indentation volume. These results indicate that theories of adhesion of soft gels need to account for both the compressibility of the gel network and a nonzero surface stress between the gel and its solvent.
A multi-resolution envelope-power based model for speech intelligibility (2013)

The speech-based envelope power spectrum model (sEPSM) presented by Jørgensen and Dau [(2011). J. Acoust. Soc. Am. 130, 1475-1487] estimates the envelope power signal-to-noise ratio (SNRenv) after modulation-frequency selective processing. Changes in this metric were shown to account well for changes of speech intelligibility for normal-hearing listeners in conditions with additive stationary noise, reverberation, and nonlinear processing with spectral subtraction. In the latter condition, the standardized speech transmission index [(2003). IEC 60268-16] fails. However, the sEPSM is limited to conditions with stationary interferers, due to the long-term integration of the envelope power, and cannot account for increased intelligibility typically obtained with fluctuating maskers. Here, a multi-resolution version of the sEPSM is presented where the SNRenv is estimated in temporal segments with a modulation-filter dependent duration. The multi-resolution sEPSM is demonstrated to account for intelligibility obtained in conditions with stationary and fluctuating interferers, and noisy speech distorted by reverberation or spectral subtraction. The results support the hypothesis that the SNRenv is a powerful objective metric for speech intelligibility prediction.
Evaluation of Infrared Brake Screening Technology: Final Report (2005)

This report documents the results of a field evaluation of the InfraRed Inspection System (IRISystem). The objective of the evaluation was to determine the effectiveness of the IRISystem in enhancing the screening of commercial motor vehicles (CMVs) in real time at the roadside for problematic conditions, primarily malfunctioning brakes. Four states - Georgia, Kentucky, North Carolina and Tennessee - participated in the evaluation for one year. CMVs were screened by IRISystem while in queue at scale sites and subsequently subjected to a CVSA Level 1 (L1) inspection. A limited number of vehicles with no apparent problematic conditions were also inspected as a control group for the study. Fifty-nine percent of the vehicles screened by the IRISystem as problematic were placed out of service (OOS) in the Level 1 inspection, mostly for brake violations (nearly 80%). The percentage of vehicles placed OOS after IRISystem screening (59%) exceeded the effectiveness criterion of 50% defined by the State of Kentucky in this program for the vehicle by-vehicle analysis. The percentage of CMVs placed out of service with brake problems increased by a factor of 2.5 after using the IRISystem to screen vehicles for inspection. Additional considerations (training requirements, set up requirements, advantages, and limitations) are also reported herein.
Synergistic effect of estradiol and testosterone protects against IL-6-inducedcardiomyocyte apoptosismediated by TGF-β1. (2018)

The balance of the serum E2/T ratio was broken in patients with heart failure, and an imbalanced E2/T ratio showed a strong association with heart failure risk factors, and E2 combined with T play a synergistic effect on anti-apoptosis involved in TGF-β1.
Frequent expression of P-glycoprotein/MDR1 by nasal T-cell lymphoma cells (1995)

The poor prognosis for patients with NL treated with chemotherapy may be explained by P-gp expression of the NL cells.
Transparent corner enhancement scheme for a DUV pattern generator (2003)

Mask cost is a key challenge for the semiconductor industry and a major issue is the write times of e-beam pattern generators. DUV pattern generators can provide high throughput, but there is a cost and time involved in qualifying these tools for IC production. To minimize this time and cost, the masks from the DUV tool should have pattern fidelity similar to that of e-beam tools. This can be done with corner enhancements on an imaging DUV mask writer. Here, we describe such a corner enhancement scheme and present results for the 65-nm-node requirements. We demonstrate how the corner radius can be tuned in a range of radii with a negligible effect on the process latitude.
Prevention of Diabetic Nephropathy in Rats by Prostaglandin E Receptor EP1-Selective Antagonist (2002)

Local production of prostaglandins (PGs) in the kidney is increased in clinical and experimental diabetic nephropathy, but the role of PGs in the pathogenesis and progression of diabetic nephropathy has remained unclear. It is here shown that an orally active antagonist selective for the PGE receptor EP1 subtype potently prevents the progression of nephropathy in streptozotocin-induced diabetic rats. The effects are shown by ameliorated renal and glomerular hypertrophy, decreased mesangial expansion, inhibited transcriptional activation of transforming growth factor-beta (TGF-beta) and fibronectin, and complete suppression of proteinuria. In vitro, this agent completely inhibits TGF-beta and fibronectin upregulation in mesangial cells cultured under high-glucose conditions. These data indicate that the PGE2-EP1 system plays a crucial role in the development of diabetic renal injury in rats. It is further shown that both the EP1 antagonist and aspirin, a nonselective PG synthase inhibitor, markedly attenuate mesangial expansion, whereas only the EP1 antagonist inhibits glomerular hypertrophy and proteinuria, which suggests that these changes are caused by different mechanisms. This study reveals a potential usefulness of selective EP1 blockade as a novel therapeutic strategy for diabetic nephropathy and also brings a new insight into our understanding of this disease.
Botanical Treatments for Hemorrhoids (2005)

Hemorrhoids are a very common condition. Hospitalbased proctoscopy studies show prevalence rates of hemorrhoids in up to 86 percent of patients studied with many in an asymptomatic state. Botanicals used internally and topically can treat early stages of hemorrhoids effectively and can be used as adjuncts in more advanced stages when surgical treatments may be necessary. The roles of butcher's broom (Ruscus aculeatus), horse chestnut (Aesculus hippocastanum), stone root (Collinsonia canadensis), witch hazel (Hammamelis virginiana), arnica (Arnica spp.), oak (Quercus spp.), chamomile (Matricaria recutita), gotu kola (Centella asiatica), calendula (Calendula officinalis), and psyllium (Plantago ovata) in hemorrhoid treatment are discussed.
Lateral patterning of GaN polarity using wet etching process (2010)

Abstract A lateral patterning of GaN polarity using wet etching process is demonstrated. The lattice polarity of a GaN film is examined by RHEED, KOH etching, micro‐Raman scattering and Kelvin force microscopy investigations. We have confirmed the high crystal quality of the lattice‐polarity inverted GaN heterostructure fabricated by the all‐wet process. The difference between the surface potentials of the N‐polar and Ga‐polar GaN regions originates from the inversion of the direction of the spontaneous polarization as deduced from the fact that the piezoelectric polarization is negligible compared with the spontaneous polarization. The KOH etching result is consistent with the above mentioned result. This work is the first and direct demonstration for the successful fabrication of the polarity‐inverted GaN heterostructure by an all‐wet process. We suggest the feasibility of the convenient all wet process for the fabrication of the quasi‐phase‐matched waveguides and photonic crystals for efficient nonlinear frequency conversion (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Genetic Basis for Vancomycin-Enhanced Cephalosporin Susceptibility in Vancomycin-Resistant Enterococci Revealed Using Counterselection with Dominant-Negative Thymidylate Synthase (2013)

Antibiotic-resistant enterococci are major causes of hospital-acquired infections. All enterococci are intrinsically resistant to most cephalosporins, antibiotics in the beta-lactam family that impair peptidoglycan synthesis by inactivating the transpeptidases responsible for cross-linking. In addition, clinical isolates of enterococci often possess acquired resistance to vancomycin, a glycopeptide antibiotic that impairs peptidoglycan biosynthesis by a mechanism distinct from that of the beta-lactams, namely, by binding to the D-Ala-D-Ala termini found in peptidoglycan precursors to prevent their utilization by biosynthetic transglycosylases. Antimicrobial synergism between vancomycin and beta-lactams against vancomycin-resistant enterococci was originally described decades ago, but the genetic basis for synergy has remained unknown. Because a complete understanding of the mechanism underlying synergy between vancomycin and beta-lactams might suggest new targets or strategies for therapeutic intervention against antibiotic-resistant enterococci, we explored the genetic basis for synergy between vancomycin and cephalosporins in Enterococcus faecalis. To do so, we developed a counterselection strategy based on a dominant-negative mutant of thymidylate synthase and implemented this approach to create a panel of mutants in vancomycin-resistant E. faecalis. Our results confirm that vancomycin promotes synergy by inducing expression of the van resistance genes, as a mutant in which the van genes are expressed in the absence of vancomycin exhibits susceptibility to cephalosporins. Further, we show that peptidoglycan precursors substituted with D-Ala-D-Lac are not required for vancomycin-enhanced cephalosporin sensitivity. Instead, production of the D,D-carboxypeptidase VanYB is both necessary and sufficient to dramatically sensitize E. faecalis to cephalosporins.
New red light-emitting conjugated rigid-rod polymer: poly(benzobisthiazole-1,4-phenylenebisvinylene) (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew red light-emitting conjugated rigid-rod polymer: poly(benzobisthiazole-1,4-phenylenebisvinylene)John A. Osaheni and Samson A. JenekheCite this: Macromolecules 1993, 26, 17, 4726–4728Publication Date (Print):August 1, 1993Publication History Published online1 May 2002Published inissue 1 August 1993https://pubs.acs.org/doi/10.1021/ma00069a051https://doi.org/10.1021/ma00069a051research-articleACS PublicationsRequest reuse permissionsArticle Views330Altmetric-Citations51LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Architecting Service-Oriented Systems (2011)

Service orientation is an approach to software systems development that has become a popular way to implement distributed, loosely coupled systems, because it offers such features as standardization, platform independence, well-defined interfaces, and tool support that enables legacy system integration. From a quality attribute point of view, the primary drivers for service orientation adoption are interoperability and modifiability. However, a common misconception is that an architecture that uses a service-oriented approach can achieve these qualities by simply putting together a set of vendor products that provide an infrastructure and then using this infrastructure to expose a set of reusable services to build systems. In reality, there are many architectural decisions that need to be made. An architectural decision that promotes interoperability or modifiability can negatively impact other qualities, such as availability, reliability, security and performance. The goal of this report is to present general guidelines for architecting service-oriented systems, how common service-oriented system components support these principles, and the effect that these principles and their implementation have on system quality attributes.