gebhart/patrepeval huggingface dataset:
[Effect of circadian rhythm on gastrointestinal motility]. (1987)

In western civilization, circadian rhythms of the gastrointestinal tract are dominated by a digestive-interdigestive rhythm: During the day interdigestive activity is rare because of frequent meal intakes prior to termination of preceding fed states: in contrast, nocturnal activity is largely interdigestive. Digestive and interdigestive functions are characterized by specific and interactive motor and secretory activity patterns. When exogenous influences via food intake are prevented, additional, underlying, endogenous, circadian rhythms are observed that modulate gastric and intestinal motility in a characteristic fashion, possibly with tight links to the central nervous system. It is likely that disturbances of physiologic circadian modulation of gastrointestinal function may have pathogenic importance.
Magnetic Force Microscopy Study of Zr<sub>2</sub>Co<sub>11</sub>‐Based Nanocrystalline Materials: Effect of Mo Addition (2015)

The addition of Molybdenum was used to modify the nanostructure and enhance coercivity of rare‐earth‐free Zr 2 Co 11 ‐based nanocrystalline permanent magnets. The effect of Mo addition on magnetic domain structures of melt spun nanocrystalline Zr 16 Co 84- x Mo x ( x = 0, 0.5, 1, 1.5, and 2.0) ribbons has been investigated. It was found that magnetic properties and local domain structures are strongly influenced by Mo doping. The coercivity of the samples increases with the increase in Mo content ( x ≤ 1.5). The maximum energy product ( B H ) max increases with increasing x from 0.5 MGOe for x = 0 to a maximum value of 4.2 MGOe for x = 1.5. The smallest domain size with a relatively short magnetic correlation length of 128 nm and largest root‐mean‐square phase shift Φ rms value of 0.66° are observed for the x = 1.5. The optimal Mo addition promotes magnetic domain structure refinement and thus leads to a significant increase in coercivity and energy product in this sample.
Mobile robots exploration through cnn-based reinforcement learning (2016)

Exploration in an unknown environment is an elemental application for mobile robots. In this paper, we outlined a reinforcement learning method aiming for solving the exploration problem in a corridor environment. The learning model took the depth image from an RGB-D sensor as the only input. The feature representation of the depth image was extracted through a pre-trained convolutional-neural-networks model. Based on the recent success of deep Q-network on artificial intelligence, the robot controller achieved the exploration and obstacle avoidance abilities in several different simulated environments. It is the first time that the reinforcement learning is used to build an exploration strategy for mobile robots through raw sensor information.
Induction of rules subject to a quality constraint: probabilistic inductive learning (1993)

Organizational databases are being used to develop rules or guidelines for action that are incorporated into decision processes. Tree induction algorithms of two types, total branching and subset elimination, used in the generation of rules, are reviewed with respect to their treatment of the issue of quality. Based on this assessment, a hybrid approach, probabilistic inductive learning (PrIL), is presented. It provides a probabilistic measure of goodness for an individual rule, enabling the user to set maximum misclassification levels, or minimum reliability levels, with predetermined confidence that each and every rule will satisfy this criterion. The user is able to quantify the reliability of the decision process, i.e., the invoking of the rules, which is of crucial importance in automated decision processes. PrIL and its associated algorithm are described. An illustrative example based on the claims process at a workers' compensation board is presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Software process decision support (2002)

In this paper, we present a decision support framework that integrates timely metrics data with simulation models of the software development process in order to support the software project management control function. This forward-looking approach provides predictions of project performance and the impact of various management decisions. Tradeoffs among performance measures are accomplished using Outcome Based Control Limits (OBCLs) and are augmented using multi-criteria utility functions and financial measures of performance to evaluate various process alternatives. The decision support framework enables the program manager to take corrective action as necessary on a project with the simulation model providing insight on potential performance impacts of the proposed corrective actions. A real world example is presented.
Across the Border (1996)

Abstract The staffing of correctional institutions has become an important process worldwide. In an effort to ascertain cross-cultural similarities and differences among correctional officers, questionnaires were sent to all 1550 officers working in four American state prisons and five Canadian federal institutions. Responses were obtained from 229 American and 339 Canadian officers. These officers were compared, using one-way ANOVA and Chi Square tests, on thirteen different variables. Five of these variables were demographic, while the remaining eight were related to the institutional environment. Statistically significant differences were found in seven (54%) of the variables. The implications for cross-cultural correctional research are discussed.
Broadband Plasmonic Microlenses Based on Patches of Nanoholes (2010)

This paper reports a new type of diffractive microlens based on finite-areas of two-dimensional arrays of circular nanoholes (patches). The plasmonic microlenses can focus single wavelengths of light across the entire visible spectrum as well as broadband white light with little divergence. The focal length is determined primarily by the overall size of the patch and is tolerant to significant changes in patch substructure, including lattice geometry and local order of the circular nanoholes. The optical throughput, however, depends sensitively on the patch substructure and is determined by the wavelengths of surface plasmon resonances. This simple diffractive lens design enables millions of broadband plasmonic microlenses to be fabricated in parallel using soft nanolithographic techniques.
Strength and Surface Morphology of Si<sub>3</sub>N<sub>4</sub> Composite Ceramics Coated with SiO<sub>2</sub> Gel (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Constraint‐based strain design using continuous modifications (CosMos) of flux bounds finds new strategies for metabolic engineering (2013)

In recent years, a growing number of metabolic engineering strain design techniques have employed constraint-based modeling to determine metabolic and regulatory network changes which are needed to improve chemical production. These methods use systems-level analysis of metabolism to help guide experimental efforts by identifying deletions, additions, downregulations, and upregulations of metabolic genes that will increase biological production of a desired metabolic product. In this work, we propose a new strain design method with continuous modifications (CosMos) that provides strategies for deletions, downregulations, and upregulations of fluxes that will lead to the production of the desired products. The method is conceptually simple and easy to implement, and can provide additional strategies over current approaches. We found that the method was able to find strain design strategies that required fewer modifications and had larger predicted yields than strategies from previous methods in example and genome-scale networks. Using CosMos, we identified modification strategies for producing a variety of metabolic products, compared strategies derived from Escherichia coli and Saccharomyces cerevisiae metabolic models, and examined how imperfect implementation may affect experimental outcomes. This study gives a powerful and flexible technique for strain engineering and examines some of the unexpected outcomes that may arise when strategies are implemented experimentally.
Advances in microelectronics and photonics (2012)

Preface Trench Gate Power MOSFET: Recent Advances & Innovations Metal Nanocrystal Floating Gate Memory Devices Double-Gate (DG) MOSFETs: A Review Effect of Independent Gate, Asymmetric & Gate-S/D Underlap Features on Nano Scale Subthreshold Double Gate MOSFET Performance Full Band Models for Strained Silicon & Germanium Devices High Performance Ge MOSFETs for Future Nanoelectron Advances in Pressure Sensors Transistor LASER: Principle, Analytical Models & Applications Advances in Semiconductor Photodetectors for Infrared Applications Process Monitoring for Nano-Imprint Lithography Index.
Bats carry pathogenic hepadnaviruses antigenically related to hepatitis B virus and capable of infecting human hepatocytes (2013)

The hepatitis B virus (HBV), family Hepadnaviridae, is one of most relevant human pathogens. HBV origins are enigmatic, and no zoonotic reservoirs are known. Here, we screened 3,080 specimens from 54 bat species representing 11 bat families for hepadnaviral DNA. Ten specimens (0.3%) from Panama and Gabon yielded unique hepadnaviruses in coancestral relation to HBV. Full genome sequencing allowed classification as three putative orthohepadnavirus species based on genome lengths (3,149-3,377 nt), presence of middle HBV surface and X-protein genes, and sequence distance criteria. Hepatic tropism in bats was shown by quantitative PCR and in situ hybridization. Infected livers showed histopathologic changes compatible with hepatitis. Human hepatocytes transfected with all three bat viruses cross-reacted with sera against the HBV core protein, concordant with the phylogenetic relatedness of these hepadnaviruses and HBV. One virus from Uroderma bilobatum, the tent-making bat, cross-reacted with monoclonal antibodies against the HBV antigenicity determining S domain. Up to 18.4% of bat sera contained antibodies against bat hepadnaviruses. Infectious clones were generated to study all three viruses in detail. Hepatitis D virus particles pseudotyped with surface proteins of U. bilobatum HBV, but neither of the other two viruses could infect primary human and Tupaia belangeri hepatocytes. Hepatocyte infection occurred through the human HBV receptor sodium taurocholate cotransporting polypeptide but could not be neutralized by sera from vaccinated humans. Antihepadnaviral treatment using an approved reverse transcriptase inhibitor blocked replication of all bat hepadnaviruses. Our data suggest that bats may have been ancestral sources of primate hepadnaviruses. The observed zoonotic potential might affect concepts aimed at eradicating HBV.
Felbamate monotherapy for partial‐onset seizures (1993)

We evaluated felbamate (FBM) monotherapy in 111 patients with uncontrolled partial-onset seizures in a multicenter, double-blind, parallel-group trial. During the 56-day baseline period, patients had at least eight partial-onset seizures and received one standard antiepileptic drug (AED) at a therapeutic level; a second AED was allowed if at a subtherapeutic level. Patients received either FBM 3,600 mg/d or valproate (VPA) 15 mg/kg/d. The baseline AED at therapeutic levels was discontinued by one-third decrements on study days 1, 14, and 28 and the sub-therapeutic AED, if any, was discontinued completely on study day 1. Study endpoints were completion of 112 study days or fulfilling one or more escape criteria. Criteria for escape relative to baseline were (1) twofold increase in monthly seizure frequency, (2) twofold increase in highest 2-day seizure frequency, (3) single generalized tonic-clonic seizure (GTC) if none occurred during baseline, or (4) significant prolongation of GTCs. The primary efficacy variable was the number of patients in each treatment group who met escape criteria. Thirty-seven patients on VPA and 18 on FBM met escape criteria (p < 0.001). Even when we considered FBM dropouts to have fulfilled escape criteria and VPA dropouts to have completed the 112-day trial, the treatment difference remained statistically significant (p = 0.039) in favor of FBM. Adverse experiences with FBM were all mild or moderate in severity. The frequency of adverse experiences was much lower during monotherapy. FBM monotherapy was effective in the treatment of partial-onset seizures with or without secondarily generalized seizures and demonstrated a favorable safety profile.
Effect of Oxygen on Methane Steam Reforming in a Sliding Discharge Reactor (2006)

Abstract Hydrogen‐rich gas can be efficiently produced in compact plasma reformers by the conversion of a variety of hydrocarbon fuels, including natural gas and gasoline. This article describes experimental and modeling progress in plasma reforming of methane using a sliding discharge reactor (SDR). Experiments have been carried out in a compact device operating at low consumed power (1–2 kW). Previous studies of methane steam reforming using a SDR at atmospheric pressure show promising results (H 2 concentration higher than 55 %). In order to study the effect of oxygen on the methane conversion and thus hydrogen production, a small amount of oxygen in the range of 7–20 % was added to the CH 4 ‐H 2 O mixture. An unexpected result was that under our experimental conditions in the SDR oxygen did not have any influence on the methane conversion. Almost the totality of added oxygen is recovered intact. Moreover, part of the H 2 produced was transformed into water by reaction with O 2 . A model describing the chemical processes based on classical thermodynamics is also proposed. The results indicate that the reactor design has to be improved in order to increase conversion and hydrogen production.
Anatomy and neurochemistry of the pair bond (2005)

Studies in monogamous rodents have begun to elucidate the neural circuitry underlying the formation and maintenance of selective pair bonds between mates. This research suggests that at least three distinct, yet interconnected, neural pathways interact in the establishment of the pair bond. These include circuits involved in conveying somatosensory information from the genitalia to the brain during sexual activity, the mesolimbic dopamine circuits of reward and reinforcement, and neuropeptidergic circuits involved specifically in the processing of socially salient cues. Here we present an integrated description of the interaction of these circuits in a model of pair bond formation in rodents with a discussion of the implications of these findings for evolution, individual variation, and human bonding.
Substrate and Mispairing Properties of 5-Formyl-2'-Deoxyuridine 5'-Triphosphate Assessed by in vitro DNA Polymerase Reactions (1997)

5-Formyluracil (fU) is one of the thymine lesions produced by reactive oxygen radicals in DNA and its constituents. In this work, 5-formyl-2'-deoxyuridine 5'-triphosphate (fdUTP) was chemically synthesized and extensively purified by HPLC. The electron withdrawing 5-formyl group facilitated ionization of fU. Thus, p K a of the base unit of fdUTP was 8.6, significantly lower than that of parent thymine (p K a = 10.0 as dTMP). fdUTP efficiently replaced dTTP during DNA replication catalyzed by Escherichia coli DNA polymerase I (Klenow fragment), T7 DNA polymerase (3'-5'exonuclease free) and Taq DNA polymerase. fU-specific cleavage of the replication products by piperidine revealed that when incorporated as T, incorporation of fU was virtually uniform, suggesting minor sequence context effects on the incorporation frequency of fdUTP. fdUTP also replaced dCTP, but with much lower efficiency than that for dTTP. The substitution efficiency for dCTP increased with increasing pH from 7.2 to 9.0. The parallel correlation between ionization of the base unit of fdUTP (p K a = 8.6) and the substitution efficiency for dCTP strongly suggests that the base-ionized form of fdUTP is involved in mispairing with template G. These data indicate that fU can be specifically introduced into DNA as unique lesions by in vitro DNA polymerase reactions. In addition, fU is potentially mutagenic since this lesion is much more prone to form mispairing with G than parent thymine.
Physiological Level Production of Antigen-Specific Human Immunoglobulin in Cloned Transchromosomic Cattle (2013)

Therapeutic human polyclonal antibodies (hpAbs) derived from pooled plasma from human donors are Food and Drug Administration approved biologics used in the treatment of a variety of human diseases. Powered by the natural diversity of immune response, hpAbs are effective in treating diseases caused by complex or quickly-evolving antigens such as viruses. We previously showed that transchromosomic (Tc) cattle carrying a human artificial chromosome (HAC) comprising the entire unrearranged human immunoglobulin heavy-chain (hIGH) and kappa-chain (hIGK) germline loci (named as κHAC) are capable of producing functional hpAbs when both of the bovine immunoglobulin mu heavy-chains, bIGHM and bIGHML1, are homozygously inactivated (double knockouts or DKO). However, B lymphocyte development in these Tc cattle is compromised, and the overall production of hpAbs is low. Here, we report the construction of an improved HAC, designated as cKSL-HACΔ, by incorporating all of the human immunoglobulin germline loci into the HAC. Furthermore, for avoiding the possible human-bovine interspecies incompatibility between the human immunoglobulin mu chain protein (hIgM) and bovine transmembrane α and β immunoglobulins (bIgα and bIgβ) in the pre-B cell receptor (pre-BCR) complex, we partially replaced (bovinized) the hIgM constant domain with the counterpart of bovine IgM (bIgM) that is involved in the interaction between bIgM and bIgα/Igβ; human IgM bovinization would also improve the functionality of hIgM in supporting B cell activation and proliferation. We also report the successful production of DKO Tc cattle carrying the cKSL-HACΔ (cKSL-HACΔ/DKO), the dramatic improvement of B cell development in these cattle and the high level production of hpAbs (as measured for the human IgG isotype) in the plasma. We further demonstrate that, upon immunization by tumor immunogens, high titer tumor immunogen-specific human IgG (hIgG) can be produced from such Tc cattle.
Cavitation of a Water Jet in Water (2012)

Cavitation is a phenomenon that occurs in liquids when the pressure drops below the vapor pressure of the liquid. Previous research has verified that cavitation bubble collapse is a dynamic and destructive process. An understanding of the behavior of cavitation is necessary to implement this destructive mechanism from an axisymmetric jet for underwater material removal. This work investigates the influence of jet pressure and nozzle diameter on the behavior of a cloud of cavitation bubbles generated by a submerged high-pressure water jet. First, this investigation is put into context with a condensed historical background of cavitation research. Second, a description of the cavitation-generating apparatus is given. Next, the experimental methods used to explore the behavior of the cavitation clouds are explained. Finally, the results of the investigation, including propagation distance, cloud width and area, pulsation frequency, and cloud front velocity are presented. Among the results is a discussion of the significant experimental factors affecting the behavior of the cavitation clouds. It is shown that the Reynolds number, specifically the diameter of the nozzle, has a significant effect on the measurements. In some cases the jet pressure, and subsequent jet velocity, had a less significant effect than was expected. Overall, this research describes the cavitation cloud formed when a submerged high-speed water jet discharges.
Transient adenosine infusion before ischemia and reperfusion protects against metabolic damage in pig hearts (1995)

We investigated whether transient adenosine (Ado) infusion before ischemia had the same effect on myocardial metabolism and function as ischemic preconditioning (IP). The control (C) group underwent 15 min of coronary artery occlusion followed by 120 min of reperfusion. The Ado group received a 15-min infusion of Ado (200 micrograms.kg-1.min-1) into the left atrium starting 20 min before ischemia. IP was elicited by two cycles of 5-min ischemia and 5-min reperfusion. In the area at risk, tissue levels of ATP, creatine phosphate (CP), and intracellular pH (pHi) were serially measured by 31P-nuclear magnetic resonance spectroscopy in 10 pigs from each group, and percent segment shortening (%SS) was measured in 7 pigs from each group. ATP and pHi were preserved after 15 min of ischemia in both Ado and IP groups [ATP = 64 +/- 7, 76 +/- 6, and 74 +/- 9% of baseline; pHi = 6.35 +/- 0.19, 6.54 +/- 0.11, and 6.64 +/- 0.11 in C, Ado, and IP groups, respectively (P < 0.05, Ado and IP vs. C)]. During reperfusion, ATP was restored progressively in both groups [71 +/- 7, 90 +/- 8, and 91 +/- 9% of baseline at 120 min of reperfusion in C, Ado, and IP groups, respectively (P < 0.05, Ado and IP vs. C)]. However, in contrast to the IP group, CP was not preserved during 15-min ischemia nor did it show persistent overshoot during reperfusion in the Ado group. There were no significant differences in %SS during ischemia and reperfusion among the three groups.(ABSTRACT TRUNCATED AT 250 WORDS)
<sup>1</sup>H NMR Spectroscopic Studies of the Conformational Isomers of Pyrrolidinofullerenes (2007)

Mixed bis-adduct derivatives of C60 containing a pyrrolidine and a malonate methano group were synthesized. Three regioisomers, the e', the trans-2, and the trans-3, were isolated and characterized. In-depth NMR studies of these methano-pyrrolidinofullerenes showed that the nitrogen inversion on the pyrrolidine moiety is not a fast event in the 1H NMR time scale as previously regarded. Solvent effects, variable temperature experiments, and protonation of the pyrrolidine nitrogen are addressed.
Synthesis and Characterization of Novel Multi-Functional Host COMPUNDS, 3. β-Cyclodextrin Derivatives Bearing Schiff Base Moiety (1991)

Abstract Four novel β-cyclodextrin derivatives bearing Schiff base moiety were first synthesized by a convenient method with satisfactory yields, and the new host molecules were characterized by 1H-NMR, FT-IR, FAB-MS spectra etc.