gebhart/patrepeval huggingface dataset:
Expression of Three Recombinant Homodimeric Isoforms of PDGF in<i>Saccharomyces cerevisiae</i>: Evidence for Difference in Receptor Binding and Functional Activities (1989)

Three recombinant homodimeric isoforms of platelet-derived growth factor (PDGF) were produced and purified in milligram quantities by expression of PDGF A- and B-chains in yeast cells. Structural analysis of the purified short and long variants of PDGF-AA (PDGF-AAS and PDGF-AAL) and PDGF-BB showed that they had been properly processed and assembled into dimers. PDGF-AAS and PDGF-AAL were found to bind only to the PDGF A-type receptor on human fibroblasts, with affinities of 0.1 and 0.2 nM, respectively. PDGF-BB bound to cells with A- and B-type receptors and to cells with B-type receptor only with affinities of 0.6 nM in both cases. Each fibroblast appeared to express about 4-5 times more B-type receptors than A-type receptors. The maximal mitogenic response to PDGF-BB of human fibroblasts was almost 2-fold higher than that induced by either of the two PDGF-AA forms. The three isoforms of PDGF also stimulated growth in soft agar of human fibroblasts with PDGF-BB inducing a higher maximal response.
A Technical Update on Mdi Based Molded Flexible Foams (1984)

Etude comparative des proprietes et utilisations de mousses de polyurethanne a base de MDI et du TDI
Low-loss single-mode wavelength multiplexer (1988)

Low-loss single-mode wavelength multiplexers which exploit wavelength coupling dependence of a fused taper coupler are commercially available.1 However, this type of wavelength multiplexer has a problem in terms of passband crosstalk and stop-band attenuation, because the coupling coefficient changes smoothly and slowly with respect to wavelength. On the other hand, wavelength multiplexers with an interference filter reported so far are apt to exhibit higher loss, although they show sharp-cut wavelength characteristics.2-4 We report a very-low-loss single-mode wavelength multiplexer using an interference filter whose insertion loss is as low as 0.52 dB at the wavelength of 1.3 μm and 0.11 dB at 1.55 μm.
Bioconversion of Low Quality Lignocellulosic Agricultural waste into Edible Protein by<i>Pleurotus djamor</i>(Rumph) Boedijn (2015)

The culture of Pleurotus djamor was procured from Directorate of Mushroom Research, Solan and was maintained on PDA medium. Eight different substrates viz., wheat straw, corn cobs, lantana twigs, rice straw, poplar leaves, parthenium leaves, sugarcane bagasse, saw dust alone or wheat straw in combination with saw dust, wheat bran, cotton seed meal, urea, CAN, waste paper, lantana twigs and corn cobs were evaluated for the yield performance and biological efficiency (BE) of P. djamor. Among the various substrates Lantana twigs was found highly suitable with 75.23% BE for the cultivation of Pink oyster mushroom (Pleurotus djamor). Combination of wheat straw+wheat bran (9:1) and wheat straw+cotton seed meal (9:1) gave better yield with biological efficiency of 78.60% and 78.56%, respectively.
High-Temperature Piezoelectric Sensing (2013)

Piezoelectric sensing is of increasing interest for high-temperature applications in aerospace, automotive, power plants and material processing due to its low cost, compact sensor size and simple signal conditioning, in comparison with other high-temperature sensing techniques. This paper presented an overview of high-temperature piezoelectric sensing techniques. Firstly, different types of high-temperature piezoelectric single crystals, electrode materials, and their pros and cons are discussed. Secondly, recent work on high-temperature piezoelectric sensors including accelerometer, surface acoustic wave sensor, ultrasound transducer, acoustic emission sensor, gas sensor, and pressure sensor for temperatures up to 1,250 °C were reviewed. Finally, discussions of existing challenges and future work for high-temperature piezoelectric sensing are presented.
Kaposi's sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cells (1997)

The recent discovery of DNA sequences of a new human herpesvirus in Kaposi's sarcoma (KS) has fueled speculation that this virus might cause KS. The mere presence, however, of a virus in a complex multicellular tumor like KS could just as well be construed as evidence of a passenger agent. We sought stronger evidence linking the KS-associated herpesvirus (KSHV) to tumor formation by using in situ hybridization to investigate the specificity, constancy, and timing of KSHV gene expression in KS tumor cells. Here we document expression of a 700-nucleotide viral RNA in every KS tumor examined, from the earliest histologically recognizable stage to advanced tumors in which the vast majority of identifiable spindle tumor cells contain this transcript. Two other KSHV RNAs were also detected in a smaller fraction of the tumor cells in all but the earliest lesion. These viral RNAs were expressed to relatively low levels in this subset; because one of these RNAs encodes a major viral capsid protein, these cells may be producing KSHV. We did not find these KSHV genes expressed in a variety of other tumors and proliferative processes, but we did detect viral gene expression in prostatic tissue, supporting a possible mechanism for sexual transmission of KSHV. The close relationship between KS and KSHV gene expression is consistent with the hypothesis that KSHV is directly involved in the etiology and pathogenesis of KS.
Inhibition of Human 20S Proteasome by Compounds from Seeds of Psoralea corylifolia (2009)

The 26S pro-teasome is composed of 20S core and 19S regulator. Since pro-teasomes interact primarily with endogenous proteins, inhi-bition of the proteolytic action of the proteasome may block the signaling action of the transcription factor NF- κB and, thus, inhibit the completion of the cell cycle and hence the mitotic proliferation of cancerous cells, leading to cell death by apopto-sis and inhibition of angiogenesis and metastasis.
Failure to deplete anti‐Galα1‐3Gal antibodies after pig‐to‐baboon organ xenotransplantation by immunoaffinity columns containing multiple Galα1‐3Gal oligosaccharides (2004)

The EIA reduces anti-alphaGal and APHA antibodies, preventing the HAR of non-transgenic pig hearts transplanted in baboons, as does hDAF expression. However, EIA does not modify the level of anti-alphaGal IgM and APHA antibodies after Tx nor the AHXR of either non-transgenic or hDAF pig organs. The increase in anti-alphaGal IgM after Tx was similar for the different antibodies of the anti-alphaGal polymorphism, and was only partially neutralized in vitro with the specific alphaGal oligosaccharide.
Points de vue sur la « Révolution ‘abbāside » (1977)

En 632, Mahomet, le fondateur d’une religion et l’organisateur d’une communauté également nouvelles et indissociables l’une de l’autre, meurt ; ses successeurs conquièrent un des plus vastes et durables Empires que l’histoire ait connus ; la dynastie des Omayyades, qui arrive au pouvoir vers 660, l’organise et, dans le premier tiers du viiie siècle, elle se présente comme une puissance qu’aucune des oppositions qu’elle rencontre ne saurait profondément ébranler. Or, en 749-750, elle est balay...
Evolving Graph Representation and Visualization (2010)

The study of evolution of networks has received increased interest with the recent discovery that many real-world networks possess many things in common, in particular the manner of evolution of such networks. By adding a dimension of time to graph analysis, evolving graphs present opportunities and challenges to extract valuable information. This paper introduces the Evolving Graph Markup Language (EGML), an XML application for representing evolving graphs and related results. Along with EGML, a software tool is provided for the study of evolving graphs. New evolving graph drawing techniques based on the force-directed graph layout algorithm are also explored. Our evolving graph techniques reduce vertex movements between graph instances, so that an evolving graph can be viewed with smooth transitions
Analysis of the cochlear microphonic to a low-frequency tone embedded in filtered noise (2012)

The cochlear microphonic was recorded in response to a 733 Hz tone embedded in noise that was high-pass filtered at 25 different frequencies. The amplitude of the cochlear microphonic increased as the high-pass cutoff frequency of the noise increased. The amplitude growth for a 60 dB SPL tone was steeper and saturated sooner than that of an 80 dB SPL tone. The growth for both signal levels, however, was not entirely cumulative with plateaus occurring at about 4 and 7 mm from the apex. A phenomenological model of the electrical potential in the cochlea that included a hair cell probability function and spiral geometry of the cochlea could account for both the slope of the growth functions and the plateau regions. This suggests that with high-pass-filtered noise, the cochlear microphonic recorded at the round window comes from the electric field generated at the source directed towards the electrode and not down the longitudinal axis of the cochlea.
Radioprotection of DNA by Thiols: Relationship between the Net Charge on a Thiol and Its Ability to Protect DNA (1988)

Sixin Zheng, Gerald L. Newton, Geoff Gonick, Robert C. Fahey, John F. Ward, Radioprotection of DNA by Thiols: Relationship between the Net Charge on a Thiol and Its Ability to Protect DNA, Radiation Research, Vol. 114, No. 1 (Apr., 1988), pp. 11-27
Herencia de la resistencia al acame de raíces en maíz dulce (Zea mays L.) (2003)

El acame de raíces en maíz dulce (Zea mays L.) es una de las principales causas de pérdidas de rendimiento debido a las dificultades que ocasionan la caída de las plantas al momento de realizar la cosecha mecánica. Los genotipos de maíz superdulces, los cuales son muy demandados por su buena calidad comestible son señalados como muy susceptibles al acame (Tracy, 1997). Los objetivos de este estudio fueron evaluar el modo de herencia de la resistencia al acame en una población de maíz "shrunken-2" (sh2) y examinar la posibles relaciones entre características morfológicas relativas al acame en condiciones de campo. Dos líneas, R33 (susceptible ) y Mp708 (resistente), fueron cruzadas, posteriormente los progenitores y las progenies resultantes (F1, F2, F3, F4, RC1; R2 y RC3) fueron evaluados en condiciones de campo durante el período 1996-1998, se llevaron registros por planta de, resistencia al acame de raíces a 2 edades del cultivo, altura de planta, altura de la mazorca y diámetro del tallo. El análisis de la media generacional indicó que mucha de la variación genética para la resistencia genética al acame de raíces fue aditiva. La estimación de heredabilidad en un sentido estricto para resistencia al acame fue moderada para los años 1996 y 1998, al menos dos genes influenciaron la resistencia. Resistencia al acame en genotipo sh2 fue mejorada por selección de pedigrí. Las evaluaciones de acame en campo a las doce semanas, después de la siembra, diferenciaron mejor los genotipos que las evaluaciones realizadas a las 8 semanas.
Fractionation of Phenolic Compounds in Red Wine (1988)

A simple analytical method was developed for the fractionation of phenolic compounds of red wine into phenolic acids (Fraction I), catechins, procyanidins, and anthocyanin monomers (Fraction II), flavonols (Fraction III), and anthocyanin polymers (Fraction IV) by passing wine through a preconditioned C<sub>18</sub> Sep-pak cartridge and eluting sequentially with methanol, 16% acetonitrile at pH 2.0, ethyl acetate, and methanol. Each fraction was then injected onto a C<sub>18</sub> HPLC column using a gradient of 3% to 100% acetonitrile in water at pH 2.6. This fractionation technique is the first step of quantitative analysis of total compounds in every fraction by a simple and rapid method: spectrophotometry.
Tumor rejection mediated by transfection with allogeneic class I histocompatibility gene. (1989)

Non-self class I histocompatibility Ag can act as strong alloantigens and be recognized as distinct targets by CTL. To study the possibility of using allograft rejection to generate tumor-specific immunity, we have introduced an allogeneic class I histocompatibility gene, the H-2Kb gene, into a k haplotype tumor, K36.16, by DNA-mediated gene transfer. The K36.16 tumor grows readily and does not confer protective immunity in AKR mice. A total of 37 H-2Kb-transfected K36.16 clones (Kb/K36.16) was isolated and studied individually. The Kb/K36.16 clones were found to differ significantly in the amount of the exogenous H-2Kb antigens expressed on their cell surface. Moreover, as a result of the transfection, the level of expression of the endogenous H-2Dk Ag was also altered when compared to that of the parental K36.16 tumor cells. All the Kb/K36.16 clones that were positive for the H-2Kb Ag were rejected by the semisyngeneic AKR mice. Moreover, some of these Kb/K36.16 clones were also rejected by syngeneic (AKR x C57BL/10)F1 mice. In consequence of immunization with the Kb/K36.16 clones, the AKR and F1 mice were able to survive a subsequent challenge of the wild-type, unmodified, parental K36.16 tumor cells. More importantly, some of these Kb/K36.16 clones demonstrated an active and specific immunotherapeutic effect, and they were able to eradicate the growth of the parental K36.16 tumor cells in AKR mice. This observation therefore reinforces the feasibility of using DNA-mediated gene transfer as a molecular approach to abrogate tumor growth.
Installing Fixed Sensors for Double Calibration and Early-warning Detection Purposes (2015)

Water utilities have started to install water quality sensors to protect their network against intentional and accidental contamination events. In this context, for taking appropriate action, not only are early-warning detection systems important, but so is the identification of the contamination source, and knowledge of the present and future contamination extent. For the latter there is a need for reliable and updated network models. The main objective of this paper is to specify which performance criteria should be considered to place water quality and water quantity sensors for both early detection and model calibration. Firstly, a brief bibliographical review is given for optimal sensor location design. Next, formulations and objectives for early-warning detection are proposed. Problem formulations that aim to minimize the estimator variance for calibration are then specified. Finally, the method is applied on the real WDN system of the CUS water service (1,000 km, 25,000 nodes and 45,000 customers).
Using design patterns and constraints to automate the detection and correction of inter-class design defects (2002)

Developing code free of defects is a major concern for the object oriented software community. The authors classify design defects as those within classes (intra-class), those among classes (inter-classes), and those of semantic nature (behavioral). Then, we introduce guidelines to automate the detection and correction of inter-class design defects. We assume that design patterns embody good architectural solutions and that a group of entities with organization similar, but not equal, to a design pattern represents an inter-class design defect. Thus, the transformation of such a group of entities, such that its organization complies exactly with a design pattern, corresponds to the correction of an inter-class design defect. We use a meta-model to describe design patterns and we exploit the descriptions to infer sets of detection and transformation rules. A constraint solver with explanations uses the descriptions and rules to recognize groups of entities with organizations similar to the described design patterns. A transformation engine modifies the source code to comply with the recognized distorted design patterns. We apply these guidelines on the Composite pattern using PTIDEJ, our prototype tool that integrates the complete guidelines.
Nuclear interferon-inducible protein 16 promotes silencing of herpesviral and transfected DNA (2013)

Mammalian cells have evolved mechanisms to silence foreign DNA introduced by viruses or by transfection. Upon herpesviral infection of cells, the viral genome is chromatinized in an attempt by the host cell to restrict expression of the viral genome. HSV ICP0 acts to counter host-intrinsic and innate responses to viral infection. We have found that nuclear interferon (IFN)-inducible protein 16 (IFI16) acts as a restriction factor against ICP0-null herpes simplex virus 1 (HSV-1) to limit viral replication and immediate-early gene expression. IFI16 promoted the addition of heterochromatin marks and the reduction of euchromatin marks on viral chromatin. IFI16 also restricted the expression of plasmid DNAs introduced by transfection but did not restrict SV40 DNA introduced into the cellular nucleus in the form of nucleosomal chromatin by viral infection. These results argue that IFI16 restricts unchromatinized DNA when it enters the cell nucleus by promoting the loading of nucleosomes and the addition of heterochromatin marks. Furthermore, these results indicate that IFI16 provides a broad surveillance role against viral and transfected DNA by promoting restriction of gene expression from the exogenous DNA and inducing innate immune responses.
The Pharmacology of Human Appetite Expression (2004)

The discovery of the adiposity signal leptin a decade ago revolutionised our understanding of the hypothalamic mechanisms underpinning the central control of ingestive behaviour. Subsequently, the structure and function of various hypothalamic peptide systems (Neuropeptide Y (NPY), Orexins, Melanocortins, Cocaine and Amphetamine Regulating Transcript (CART), Galanin/Galanin Like Peptides (GALP) and endocannabinoids) have been characterised in detail in rodent models. The therapeutic benefit of targeting these systems remains to be discovered. More is becoming known about the pharmacological potential of peripheral, meal-induced, episodic endogenous peptides. Hormones such as Cholecystokinin (CCK), Gastrin Releasing Peptides (GRP), Glucagon-Like Peptide I (GLP-1) Enterostatin, Amylin, Peptide YY (PYY) and Ghrelin are released prior to, during and/or after a meal, controlling intake and subjective feelings of appetite (hunger and satiety). In addition, there is an expanding body of literature detailing the effects of a wide variety of drugs on human appetite and food intake. Some of these drugs act upon CNS monoamine systems such as Serotonin (5-HT). Dopamine (DA) and Noradrenaline (NA), have long been implicated in appetite regulation. Detailed examination of both the effect of agonising endogenous gut peptide systems and the effect of various monoaminergic drugs on the expression of human appetite can provide a greater understanding of mechanisms underpinning normal appetite regulation. However, such an understanding must be based on knowledge of the effect of the treatment on meal size, eating rate, meal pattern, food choice and the subjective experience of appetite flux (hunger and satiety), and notjust food intake.
A Miniature Compliance Monitor for Eyedrop Medication (1984)

• We developed an eyedrop medication monitor that electronically records the date and time of each medication administration over a six-week period. It records a medication usage in a 15-minute interval when the cap is removed from the bottle and the bottle is inverted. The electronic components housed inside the bottle weigh 7.5 g, including the batteries, and the total volume of the circuit is 7.5 cc. The monitor resembles commercially available 30-mL eyedrop bottles in size, shape, and weight. The monitor is accurate when tested against known patterns of usage. The electronic eyedrop monitor should be useful in assessing compliance with eyedrop medications.
Presurgical Nasoalveolar Molding in a Neonate with Unilateral Cleft Lip and Palate (2018)

The innate fissure of lip and hard palate represents the most common inborn craniofacial oddity originated by unusual facial development through gestation. It varies in form and severity. The rehabilitation amounts to a committed approach of care for the afflicted child since its detection. The craniofacial team works together to arrange the complex surgical and nonsurgical treatment plan. The diverse stratagem has been endeavored to lessen the cleft space and achieve esthetic results postsurgically. The presurgical nasoalveolar molding (PNAM) technique represents an essential part of the treatment of child with orofacial split. It ameliorates the orientation of the palatal ridges and decreases the distance between the cleft lip segments, provides symmetry to severely disfigure nasal gristle. The case report presents a concise insight concerning PNAM approach in unilateral cleft lip and palate (CLCP) patient with excellent presurgical outcome.
Vital Sign Radar : Development of a Compact, Highly Integrated 60GHz FMCW Radar for Human Vital Sign Monitoring (2016)

Supervision of human vital signs has always been an essential part in healthcare. Nowadays there is a strong interest in contact-less monitoring methods as they operate less static and offer higher flexibility to the people observed. Recent industrial development enabled radar functionality to be packed in single-chip solutions, decreasing application complexity and speeding up designs. Within this thesis, a vital sign radar prototype has been developed utilising a recently released 60GHz frequency modulated continous wave single-chip radar. The electronics development has been focused on compactness and high system integration. Special attention has been given to the onboard analogue signal filtering and digital data preprocessing. The resulting prototype radar is then tested and evaluated using test scenarios with increasing difficulty. The final experiments prove that the radar is capable of tracking human respiration rate and heartbeat simultaneously from a distance of 1m. It can be concluded that modern radar devices may be significantly miniaturised for e.g. portable operation while offering a wide variety of application possibilities including vital sign monitoring.
The Kinetics of Early Inflammatory Events During Experimental Pneumonia Due to Legionella pneumophila in Guinea Pigs (1983)

An animal model of Legionella pneumophila pneumonia was developed to study aerosol infection, pathogenesis, and pulmonary host defense mechanisms. Guinea pigs were exposed in an inhalation facility that limited the aerosol of L pneumophila to the snout. Bronchoalveolar lavage was used to sample airspace cells, secretions, and bacteria during developing infection in 79 exposed animals and 13 uninfected controls. An influx of polymorphonuclear neutrophils followed exponential bacterial growth during the initial three days of infection and coincided with limitation of the increase in bacteria recovered. A macrophage influx occurred at three to five days. Bacteria were eliminated from the lung by 11 days after exposure. Albumin in lavage fluid peaked at two days. Most viable L pneumophila organisms were associated with alveolar macrophages, whereas most of the bacteria associated with polymorphonuclear neutrophils were nonviable. Recruited, and possibly immune, defenses appear to be required for successful resolution of legionella pneumonia.
Increasing User&amp;#146;s Privacy Control through Flexible Web Bug Detection (2006)

People usually provide personal information when visiting Web sites, even though they are not aware of this fact. In some cases, the collected data is misused, resulting on user privacy violation. The existing tools which aim at guaranteeing user privacy usually restrict access to personalized services. In this work, we propose the Web bug detector. Upon detecting and informing users about browsing tracking mechanisms which invisibly collect their personal information when visiting sites, it represents an alternative that provides a better control over privacy while allowing personalization. Through experimental results, we demonstrate the applicability of our strategy by applying the detector to a real workload. We found that about 5.37% of user's requests were being tracked by third-party sites.