gebhart/patrepeval huggingface dataset:
Role of SODD in Regulation of Tumor Necrosis Factor Responses (2003)

Signaling from tumor necrosis factor receptor type 1 (TNFR1) can elicit potent inflammatory and cytotoxic responses that need to be properly regulated. It was suggested that the silencer of death domains (SODD) protein constitutively associates intracellularly with TNFR1 and inhibits the recruitment of cytoplasmic signaling proteins to TNFR1 to prevent spontaneous aggregation of the cytoplasmic death domains of TNFR1 molecules that are juxtaposed in the absence of ligand stimulation. In this study, we demonstrate that mice lacking SODD produce larger amounts of cytokines in response to in vivo TNF challenge. SODD-deficient macrophages and embryonic fibroblasts also show altered responses to TNF. TNF-induced activation of NF-kappaB is accelerated in SODD-deficient cells, but TNF-induced c-Jun N-terminal kinase activity is slightly repressed. Interestingly, the apoptotic arm of TNF signaling is not hyperresponsive in the SODD-deficient cells. Together, these results suggest that SODD is critical for the regulation of TNF signaling.
797. A Trans-Dominant Negative and Replication Defective HSV-1 Vector for In Vivo and Ex Vivo Gene Transfer (2004)

HSV replicates in epithelial cells and establishes life-long latent infection in neuronal cell bodies of the sensory ganglia. This dual life cycle, and its ability to package 30-50kb of transgene, make it an attractive vehicle for gene transfer. However, both replication-defective and neuroattenuated viruses are replication competent in the context of wild-type virus, raising safety concerns about their use for human gene therapy.
Sharp thinking (2005)

Nurses are the healthcare professionals most at risk from neeldestick and sharps injuries, according to the latest figures from the RCN's EPINet project. During 2004, 1,990 injuries were reported from the 20 self-selecting participating sites. Nurses sustained 43 per cent of these injuries. Disposable syringes and needles were the most common equipment to cause injury. Although discouraged, 4 per cent of injuries occurred during recapping of needles. Just under a third of injuries were sustained by staff other than the original user of the sharp.
STUDIES ON THE OPTIMUM CONDITIONS OF EXTRACTION OF SILICON SPECIES FROM PLANTS WITH WATER (1976)

The silicon level was determined in leaves, stem and root of Urtica dioica L. during its growth and the kinetics of extraction of molybdate-reactive silicon species from leaves was studied at 20, 50 and 90° C. A rapid extraction was observed at 90 and 50° C. The extent of extraction did not exceed 50 per cent of the total silicon with both the fresh and dry leaves. The balance of silicon in the extraction was made and optimum conditions were established for the extraction of molybdate-reactive silicon species from leaves.
Organosoluble polyimides derived from asymmetric 2‐substituted‐and 2,2′,6‐trisubstituted‐4,4′‐oxydianilines (2013)

Abstract We report a new method for the preparation of asymmetric diamines using 4,4′‐oxydianiline (4,4′‐ ODA ) as the starting material. By controlling the equivalents of bromination agent, N ‐bromosuccinimide, we were able to attach bromide and phenyl substituents at the 2‐ or 2,2′,6‐positions of 4,4′‐ ODA . Thus, four new asymmetric aromatic diamines, 2‐bromo‐4,4′‐oxydianiline (6), 2,2′,6‐tribromo‐4,4′‐oxydianiline (7), 2‐phenyl‐4,4′‐oxydianiline (8) and 2,2′,6‐triphenyl‐4,4′‐oxydianiline (9), were synthesized by this method. Their structural asymmetry was confirmed using 1 H NMR spectroscopy. Asymmetric polyimides ( PI10–PI13 ) were prepared from these diamines and three different dianhydrides (pyromellitic dianhydride ( PMDA ), 3,3′,4,4′‐biphenyltetracarboxylic dianhydride and 2,2‐bis(3,4‐dicarboxyphenyl)hexafluoropropane dianhydride) in refluxing m ‐cresol. The formed polyimides, except PI10a derived from 6 and PMDA , were all soluble in m ‐cresol without premature precipitation during polymerization. These polyimides with inherent viscosity of 0.41–0.96 dL g −1 , measured at a concentration of 0.5 g dL −1 in N ‐methyl‐2‐pyrrolidone at 30 °C, can form tough and flexible films. Because of the structural asymmetry, they also exhibited enhanced solubility in organic solvents. Especially, polyimides PI11a and PI13a derived from 7 and 9 with rigid PMDA were soluble in various organic solvents at room temperature. The structural asymmetry of the prepared polyimides was also evidenced from 1 H NMR spectroscopy. In the 1 H NMR spectrum of PI11a , the protons of pyromellitic moiety appeared in an area ratio of 1:2:1 at three different chemical shifts, which were assigned to head‐to‐head, head‐to‐tail and tail‐to‐tail configurations, respectively. These polyimides also exhibited good thermal stability. Their glass transition temperatures ranged from 297 to 344 °C measured using thermal mechanical analysis. © 2013 Society of Chemical Industry
Intronic pentanucleotide TTTCA repeat insertion in the SAMD12 gene causes familial cortical myoclonic tremor with epilepsy type 1 (2018)

Familial cortical myoclonic tremor with epilepsy is an autosomal dominant neurodegenerative disease, characterized by cortical tremor and epileptic seizures. Although four subtypes (types 1-4) mapped on different chromosomes (8q24, 2p11.1-q12.2, 5p15.31-p15.1 and 3q26.32-3q28) have been reported, the causative gene has not yet been identified. Here, we report the genetic study in a cohort of 20 Chinese pedigrees with familial cortical myoclonic tremor with epilepsy. Linkage and haplotype analysis in 11 pedigrees revealed maximum two-point logarithm of the odds (LOD) scores from 1.64 to 3.77 (LOD scores in five pedigrees were >3.0) in chromosomal region 8q24 and narrowed the candidate region to an interval of 4.9 Mb. Using whole-genome sequencing, long-range polymerase chain reaction and repeat-primed polymerase chain reaction, we identified an intronic pentanucleotide (TTTCA)n insertion in the SAMD12 gene as the cause, which co-segregated with the disease among the 11 pedigrees mapped on 8q24 and additional seven unmapped pedigrees. Only two pedigrees did not contain the (TTTCA)n insertion. Repeat-primed polymerase chain reaction revealed that the sizes of (TTTCA)n insertion in all affected members were larger than 105 repeats. The same pentanucleotide insertion (ATTTCATTTC)58 has been reported to form RNA foci resulting in neurotoxicity in spinocerebellar ataxia type 37, which suggests the similar pathogenic process in familial cortical myoclonic tremor with epilepsy type 1.
Low-temperature susceptibility of concentrated magnetic fluids (2004)

The initial susceptibility of concentrated magnetic fluids (ferrocolloids) has been experimentally investigated at low temperatures. The results obtained indicate that the interparticle dipole-dipole interactions can increase the susceptibility by several times as compared to the Langevin value. It is shown that good agreement between recent theoretical models and experimental observations can be achieved by introducing a correction for coefficients in the series expansion of susceptibility in powers of density and aggregation parameter. A modified equation for equilibrium susceptibility is offered to sum over corrections made by Kalikmanov (Statistical Physics of Fluids, Springer-Verlag, Berlin, 2001) and by B. Huke and M. Lucke (Phys. Rev. E 67, 051403, 2003). The equation gives good quantitative agreement with the experimental data in the wide range of temperature and magnetic particles concentration. It has been found that in some cases the magnetic fluid solidification occurs at temperature several tens of kelvins higher than the crystallization temperature of the carrier liquid. The solidification temperature of magnetic fluids is independent of particle concentration (i.e., magneto-dipole interparticle interactions) and dependent on the surfactant type and carrier liquid. This finding allows us to suggest that molecular interactions and generation of some large-scale structure from colloidal particles in magnetic fluids are responsible for magnetic fluid solidification. If the magnetic fluid contains the particles with the Brownian relaxation mechanism of the magnetic moment, the solidification manifests itself as the peak on the "susceptibility-temperature" curve. This fact proves the dynamic nature of the observed peak: it arises from blocking the Brownian mechanism of the magnetization relaxation.
Traditional Uses, Phytochemistry, Pharmacology, and Quality Control of Dendrobium officinale Kimura et. Migo (2021)

<i>Dendrobium officinale</i>, a well-known plant used as a medicinal and food homologous product, has been reported to contain various bioactive components, such as polysaccharides, bibenzyls, phenanthrenes, and flavonoids. It is also widely used as a traditional medicine to strengthen "Yin", nourish heart, tonify five viscera, remove arthralgia, relieve fatigue, thicken stomach, lighten body, and prolong life span. These traditional applications are in consistent with modern pharmacological studies, which have demonstrated that <i>D. officinale</i> exhibits various biological functions, such as cardioprotective, anti-tumor, gastrointestinal protective, anti-diabetes, immunomodulatory, anti-aging, and anti-osteoporosis effects. In this review, we summarize the research progress of <i>D. officinale</i> from November 2016 to May 2021 and aim to better understand the botany, traditional use, phytochemistry, and pharmacology of <i>D. officinale</i>, as well as its quality control and safety. This work presents the development status of <i>D. officinale</i>, analyzes gaps in the current research on <i>D. officinale</i>, and raises the corresponding solutions to provide references and potential directions for further studies of <i>D. officinale</i>.
Novel sulfur‐containing ferrocene polymers (1996)

Abstract Ferrocene‐containing polymers were synthesized via addition reaction of 1,1′‐dimercaptoferrocene ( 1 ) and 1,1′‐bis(2‐mercaptoethyl)ferrocene ( 2 ) to various diolefinic monomers such as dimethacrylates, divinyl ethers, divinyl sulfones and others. The dithiol 1 was also used as a monomer in condensation reactions with bifunctional acid chlorides. The polymerization of propylene sulfide in the presence of 1 as a bifunctional initiator was found to lead to polymers with a single central ferrocene unit.
Parathyroid hormone-related protein-(1-34) inhibits intrinsic pump activity of isolated murine lymph vessels (2001)

Parathyroid hormone-related protein (PTHrP) was originally found as a tumor-derived vasoactive factor and has also been known to produce significant relaxation of vascular smooth muscles. Thus effects of PTHrP-(1-34), a PTH receptor-binding domain, on spontaneous lymphatic pump activity was investigated in isolated pressurized lymph vessels of mice. Low concentrations (1 x 10(-10) and 3 x 10(-10) M) of PTHrP-(1-34) dilated lymph vessels and reduced the frequency of pump activity, whereas high concentrations (1 x 10(-9) to 1 x 10(-8) M) of PTHrP-(1-34) caused dilation with cessation of the lymphatic pump activity. N(omega)-nitro-L-arginine methyl ester (L-NAME; 3 x 10(-5) M) but not indomethacin (1 x 10(-5) M) significantly reduced the PTHrP-(1-34)-induced inhibitory responses of the lymphatic pump activity. In the presence of L-NAME (3 x 10(-5) M) and L-arginine (1 x 10(-3) M), the L-NAME-induced inhibition in the PTHrP-(1-34)-mediated responses was significantly reduced. Glibenclamide (1 x 10(-6) M) significantly suppressed the inhibitory responses of the lymphatic pump activity induced by PTHrP-(1-34) and S-nitroso-N-acetyl-penicillamine. The PTHrP-(1-34)-mediated inhibitory responses were significantly reduced by treatment with PTHrP-(7-34) (1 x 10(-7) M). These results suggest that PTHrP-(1-34) inhibits spontaneous pump activity of the isolated lymph vessels via PTH receptors and that production and release of endogenous nitric oxide and activation of ATP-sensitive K(+) channels in the lymph vessels contribute to the PTHrP-(1-34)-mediated inhibitory responses of the lymphatic pump activity.
Chemical Geroprotectors and the Problem of Increasing the Life Span (1975)

The information available in the literature about the applications of geroprotectors — chemical substances used in experimental gerontology to increase the life span and to retard ageing — are described systematically and analysed. The proposed mechanisms of ageing are discussed only in connection with the characteristics of the action of the geroprotectors. The bibliography includes 100 references.
Polymerization of formaldehyde and the physical properties of the polymerization products. I. (1981)

Polymerization of formaldehyde carried out in the solution method and gas supply method using various initiators at various temperatures and characterization of the polyoxymethylene obtained are discussed. In both modes of polymerization, polyoxymethylenes with sufficient molecular weight (M̄n) and small M̄w/M̄n were obtained. The toughness of polymer as determined by the M̄w/M̄n of the polymer with sufficient Mn was confirmed.
SHORTER NOTICES (1998)

SHORTER NOTICES Get access R. I. MOORE R. I. MOORE University of Newcastle upon Tyne Search for other works by this author on: Oxford Academic Google Scholar The English Historical Review, Volume CXIII, Issue 450, February 1998, Pages 135–136, https://doi.org/10.1093/ehr/CXIII.450.135 Published: 01 February 1998
Continuous Direct Spinning of Fibers of Single‐Walled Carbon Nanotubes with Metallic Chirality (2011)

The electrical properties of single-walled carbon nanotubes depend critically on their structure. Using a method for spinning of nanotube based fibers directly from the synthesis reaction zone, the critical control of sulfur precursors in the reaction allows the production of a fiber consisting of single-walled carbon nanotubes with the same, sought after metallic properties, and chiral angle. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Phase I, Pharmacokinetic, and Pharmacodynamic Study of AMG 479, a Fully Human Monoclonal Antibody to Insulin-Like Growth Factor Receptor 1 (2009)

AMG 479 can be administered safely at 20 mg/kg IV Q2W. The absence of severe toxicities, attainment of serum concentrations associated with high levels of IGF-1R binding on neutrophils, and provocative antitumor activity warrant additional studies of this agent.
The standard generalized markup language for electronic patient records (1998)

A pilot study at the Robert Jones and Agnes Hunt Orthopaedic Hospital, Oswestry, UK, examined the use of the Standard Generalized Markup Language (SGML) for electronic patient records. Seven hundred patients had their text records encoded in SGML and 14 of these patients had legacy, laboratory and other data included. Records were incorporated in a commercial SGML database to demonstrate in-context searching. A commercial SGML browser allowed rapid access to clinical events in large records. A study of comparative file sizes between formats was performed. The acceptability of electronic records was assessed with clinicians. Specifications for the system are discussed and the relationship with traditional technologies explained. SGML represents a suitable format for the manipulation and publication of electronic patient records.
Distinct patterns of APP processing in the CNS in autosomal-dominant and sporadic Alzheimer disease (2012)

Autosomal-dominant Alzheimer disease (ADAD) is a genetic disorder caused by mutations in Amyloid Precursor Protein (APP) or Presenilin (PSEN) genes. Studies from families with ADAD have been critical to support the amyloid cascade hypothesis of Alzheimer disease (AD), the basis for the current development of amyloid-based disease-modifying therapies in sporadic AD (SAD). However, whether the pathological changes in APP processing in the CNS in ADAD are similar to those observed in SAD remains unclear. In this study, we measured β-site APP-cleaving enzyme (BACE) protein levels and activity, APP and APP C-terminal fragments in brain samples from subjects with ADAD carrying APP or PSEN1 mutations (n = 18), patients with SAD (n = 27) and age-matched controls (n = 22). We also measured sAPPβ and BACE protein levels, as well as BACE activity, in CSF from individuals carrying PSEN1 mutations (10 mutation carriers and 7 non-carrier controls), patients with SAD (n = 32) and age-matched controls (n = 11). We found that in the brain, the pattern in ADAD was characterized by an increase in APP β-C-terminal fragment (β-CTF) levels despite no changes in BACE protein levels or activity. In contrast, the pattern in SAD in the brain was mainly characterized by an increase in BACE levels and activity, with less APP β-CTF accumulation than ADAD. In the CSF, no differences were found between groups in BACE activity or expression or sAPPβ levels. Taken together, these data suggest that the physiopathological events underlying the chronic Aβ production/clearance imbalance in SAD and ADAD are different. These differences should be considered in the design of intervention trials in AD.
Linker Variation and Structure–Activity Relationship Analyses of Carboxylic Acid-based Small Molecule STAT3 Inhibitors (2018)

The molecular determinants for the activities of the reported benzoic acid (SH4-54), salicylic acid (BP-1-102), and benzohydroxamic acid (SH5-07)-based STAT3 inhibitors were investigated to design optimized analogues. All three leads are based on an <i>N</i>-methylglycinamide scaffold, with its two amine groups condensed with three different functionalities. The three functionalities and the CH<sub>2</sub> group of the glycinamide scaffold were separately modified. The replacement of the pentafluorobenzene or cyclohexylbenzene, or replacing the benzene ring of the aromatic carboxylic or hydroxamic acid motif with heterocyclic components (containing nitrogen and oxygen elements) all decreased potency. Notably, the Ala-linker analogues, <b>1a</b> and <b>2v</b>, and the Pro-based derivative <b>5d</b>, all with (<i>R</i>)-configuration at the chiral center, had improved inhibitory activity and selectivity against STAT3 DNA-binding activity <i>in vitro</i>, with IC<sub>50</sub> of 3.0 ± 0.9, 1.80 ± 0.94, and 2.4 ± 0.2 μM, respectively. Compounds <b>1a</b>, <b>2v</b>, <b>5d</b>, and other analogues inhibited constitutive STAT3 phosphorylation and activation in human breast cancer and melanoma lines, and blocked tumor cell viability, growth, colony formation, and migration <i>in vitro</i>. Pro-based analogue, <b>5h</b>, with a relatively polar tetrahydropyranyl (THP) ring, instead of the cyclohexyl, showed improved permeability. In general, the (<i>R</i>)-configuration Pro-based analogs showed the overall best profile, including physicochemical properties (e.g., microsomal metabolic stability, Caco-2 permeability), and in particular, <b>5d</b> showed improved tumor-cell specificity.
Rising Rates of Carbapenem-Resistant Enterobacteriaceae in Community Hospitals: A Mixed-Methods Review of Epidemiology and Microbiology Practices in a Network of Community Hospitals in the Southeastern United States (2014)

The rate of CRE detection increased fivefold in community hospitals in the southeastern United States from 2008 to 2012. Despite this, our estimates are likely underestimates of the true rate of CRE detection, given the low adoption of the carbapenem breakpoints recommended in the 2010 CLSI guidelines.
ONE-STEP GROWTH CURVE OF WESTERN EQUINE ENCEPHALOMYELITIS VIRUS ON CHICKEN EMBRYO CELLS GROWN IN VITRO AND ANALYSIS OF VIRUS YIELDS FROM SINGLE CELLS (1954)

The rate of adsorption of WEE virus onto chicken embryo cells in vitro was determined both on a cell layer and on a cell suspension. One-step growth curves were determined in cell suspensions and on cell layers. The latent period varied between 2 and 3(1/2) hours; it was shorter on cell layers and decreased with higher multiplicity of infection. The shortest period is probably the real latent period. The growth curves of the virus showed an initial exponential rise and reached a maximal constant value after 6 to 8 hours. The maximum virus yield per cell varied between 200 and 1000 on the cell layer, and between 100 and 200 in suspended cells. The yield of single infected cells was determined. An analysis of the distributions of the individual yields obtained after various periods of virus growth led to two main conclusions: (1) that virus is released from the same cell over a long period of time; (2) that one phase of the intracellular virus growth is exponential.
Ligand-Assisted Metal-Centered Electrocatalytic Hydrogen Evolution upon Reduction of a Bis(thiosemicarbazonato)Ni(II) Complex (2018)

In this study, we report the electrocatalytic behavior of the neutral, monomeric Ni(II) complex of diacetyl-bis(N-4-methyl-3-thiosemicarbazonato), NiL1, for ligand-assisted metal-centered hydrogen evolution in acetonitrile (ACN) and dimethylformamide (DMF). Using foot-of-the-wave analysis (FOWA), NiL1 displays a maximum turnover frequency (TOF) of 4200 and 1200 s–1 for acetic acid (CH3COOH) in ACN and DMF, whereas for trifluoroacetic acid (CF3COOH) the TOFs are 1300 and 120 s–1 in ACN and DMF, respectively. In ACN, the overpotentials are 0.53 and 0.67 V for CH3COOH and CF3COOH, respectively. In DMF, the overpotential is 0.85 V for CH3COOH. First-order dependence with respect to the catalyst is established. NiL1 displays a minimum Faradaic efficiency of 87% from controlled potential electrolysis. Gas analysis from controlled potential electrolysis in both ACN and DMF using CH3COOH and CF3COOH confirms NiL1 as an electrocatalyst to produce H2. In ACN, TONs of 48 and 24 were obtained for CH3COOH and CF3COOH, respectively in 4 h. In DMF, TONs of 13 and 3 were obtained for CH3COOH and CF3COOH, respectively. The H2 evolution reaction was evaluated using deuterated acid, demonstrating an inverse kinetic isotope, which is consistent with formation of a metal hydride intermediate. A proposed ligand-assisted metal-centered mechanism for HER is supported by computational investigations. All catalytic intermediates in the proposed mechanism were structurally and energetically characterized using density functional theory (DFT), with the B3LYP/6-311g(d,p) and BP86/TZV/P in solution modeled via polarizable continuum model. The final step of catalysis involves the reaction of [HNi(L1·)]− with H+ generating H2. The correctness of proposed mechanism was confirmed by location of corresponding transition state (TS) having single imaginary frequency (i1786 cm–1).
Characterization study of electric arc furnace dust phases (2006)

Electric arc furnace dust (EAFD) is a solid waste generated in the collection of particulate material during steelmaking process in electric arc furnace. The aim of this work is to carry out a chemical and structural characterization of two EAFD samples with different Zn contents. Optical emission spectroscopy via inductively coupled plasma (ICP), X ray diffractometry (XRD) and Mössbauer spectroscopy analysis were carried out in such EAFD samples. From XRD measurements, the samples exhibits the following phases: ZnFe2O4, Fe3O4, MgFe2O4, FeCr2O4, Ca0.15Fe2.85O4, MgO, Mn3O4, SiO2 and ZnO. The phases detected by Mössbauer spectroscopy were: ZnFe2O4, Fe3O4, Ca0.15Fe2.85O4 and FeCr2O4. Magnesium ferrite (MgFe2O4), observed in the XRD patterns as overlapped peaks, was not identified in the Mössbauer spectroscopy analysis.