gebhart/patrepeval huggingface dataset:
FROM SUSTAINABLE DEVELOPMENT TO SUSTAINABILITY, THROUGH EXCELLENCE IN MANAGEMENT – A THEORETICAL APPROACH (2022)

The desired corporate sustainability, and particularly the agri-food sector needs to go through sustainable development, and management excellence, which we vehemently discussed in the doctorate in agribusiness, and sustainability. Hence a question arose: is there a management system that offers sustainability to companies? Our objective was: to identify bibliographies that support the hypothesis that there is a gap to be filled, precisely the lack of management systems that provide economic, social, , and environmental sustainability to these companies. We propose specific objectives: 1. Collect and identify scientific articles published in appropriate journals, based on the keywords; 2. Verify and underst, and if the authors propose a management system focused on sustainable development and sustainability; 3. Verify that the European Quality Foundation's Management Excellence Model would be appropriate for the corporate sustainability proposal. We conducted a collection of 51 articles from the Scopus, and Scholar Google platforms, and qualitative analysis of the bibliographic search data. The research-validated the hypothesis, and demonstrated that there is no management system that definitely provides companies with the desired sustainability. Therefore, it is challenging for further studies to clarify this issue, and the ODS EC 2030 to be addressed.
Anaerobiosis and plant growth hormones induce two genes encoding 1-aminocyclopropane-1-carboxylate synthase in rice (Oryza sativa L.). (1993)

The plant hormone ethylene is believed to be responsible for the ability of rice to grow in the deepwater regions of Southeast Asia. Ethylene production is induced by hypoxia, which is caused by flooding, because of enhanced activity of 1-aminocyclopropane-1-carboxylic acid (ACC) synthase, the key enzyme in the ethylene biosynthetic pathway. We have cloned three divergent members, (OS-ACS1, OS-ACS2, and OS-ACS3), of a multigene family encoding ACC synthase in rice. OS-ACS1 resides on chromosome 3 and OS-ACS3 on chromosome 5 in the rice genome. The OS-ACS1 and OS-ACS3 genes are induced by anaerobiosis and indoleacetic acid (IAA) + benzyladenine (BA) + LiCl treatment. The anaerobic induction is differential and tissue specific; OS-ACS1 is induced in the shoots, whereas OS-ACS3 is induced in the roots. These inductions are insensitive to protein synthesis inhibitors, suggesting that they are primary responses to the inducers. All three genes are actually induced when protein synthesis is inhibited, indicating that they may be under negative control or that their mRNAs are unstable. The OS-ACS1 gene was structurally characterized, and the function of its encoded protein (M(r) = 53 112 Da, pI 8.2) was confirmed by expression experiments in Escherichia coli. The protein contains all eleven invariant amino acid residues that are conserved between aminotransferases and ACC synthases cloned from various dicotyledonous plants. The amino acid sequence shares significant identity to other ACC synthases (69-34%) and is more similar to sequences in other plant species (69% with the tomato LE-ACS3) than to other rice ACC synthases (50-44%). The data suggest that the extraordinary degree of divergence among ACC synthase isoenzymes within each species arose early in plant evolution and before the divergence of monocotyledonous and dicotyledonous plants.
Transcutaneous Immunization with Cholera Toxin B Subunit Adjuvant Suppresses IgE Antibody Responses Via Selective Induction of Th1 Immune Responses (2003)

Topical application of cholera toxin (CT) onto mouse skin can induce a humoral immune response to CT as well as to coadministered Ags. In this study, we examined the nontoxic cell-binding B subunit of CT (CTB) as a potential adjuvant for cutaneous immune responses when coadministered with the prototype protein Ag, OVA. CTB applied onto skin induced serum Ab responses to itself with magnitudes comparable to those evoked by CT but was poorly efficient at promoting systemic Ab responses to coadministered OVA. However, transcutaneous immunization (TCI) with either CT or CTB and OVA led to vigorous OVA-specific T cell proliferative responses. Furthermore, CTB potentiated Th1-driven responses (IFN-gamma production) whereas CT induced both Th1 and Th2 cytokine production. Coadministration of the toxic subunit CTA, together with CTB and OVA Ag, led to enhanced Th1 and Th2 responses. Moreover, whereas TCI with CT enhanced serum IgE responses to coadministered OVA, CTB suppressed these responses. TCI with either CT or CTB led to an increased accumulation of dendritic cells in the exposed epidermis and the underlying dermis. Thus, in contrast to CT, CTB appears to behave very differently when given by the transcutaneous as opposed to a mucosal route and the results suggest that the adjuvanticity of CT on Th1- and Th2-dependent responses induced by TCI involves two distinct moieties, the B and the A subunits, respectively.
Suppression of murine SLE by oral anti-CD3: inducible CD4+CD25-LAP+ regulatory T cells control the expansion of IL-17+ follicular helper T cells (2009)

Lupus is an antibody-mediated autoimmune disease. The production of pathogenic, class switched and affinity maturated autoantibodies in lupus is dependent on T cell help. A potential mechanism of disease pathogenesis is a lack of control of pathogenic T helper cells by regulatory T cells in lupus. It has been repeatedly shown that the naturally occurring CD4+CD25+ regulatory T cells in lupus prone mice and patients with SLE are defective both in frequency and function. Thus, the generation of inducible regulatory T cells that can control T cell help for autoantibody production is a potential avenue for the treatment of SLE. We have found that oral administration of anti-CD3 monoclonal antibody attenuated lupus development and arrested on-going disease in lupus prone SNF1 mice. Oral anti-CD3 induces a CD4+CD25-LAP+ regulatory T cell that secrets high levels of TGF-beta and suppresses in vitro in TFG-beta-dependent fashion. Animals treated with oral anti-CD3 had less glomerulonephritis and diminished levels of anti-dsDNA autoantibodies. Oral anti-CD3 led to a downregulation of IL-17+CD4+ICOS-CXCR5+ follicular helper T cells, CD138+ plasma cells and CD73+ mature memory B cells. Our results show that oral anti-CD3 induces CD4+CD25-LAP+ regulatory T cells that suppress lupus in mice and is associated with downregulation of T cell help for autoantibody production.
GermlineTP53 mutations and Li-Fraumeni syndrome (2003)

There are now reports of nearly 250 independent germline TP53 (p53) mutations in over 100 publications. Such mutations are typically associated with Li-Fraumeni or Li-Fraumeni-like syndrome, although many have been identified in cohorts of patients with tumors considered to be typical of LFS. In general, the spectrum of mutations that has been detected in the germline reflects that found in tumors, although there are some notable exceptions in certain tumor types. Detailed knowledge of the pedigrees allows a comprehensive analysis of genotype-phenotype correlations and an understanding of the tumors that are associated with germline TP53 mutations. This review will discuss the spectrum of mutations and the methods for mutation detection, the tumors associated with inheritance of a germline mutation, and some of the ethical and clinical problems in patients with a germline TP53 mutation.
Digital Laser Ranging and Tracking Using a Compound Axis Servomechanism (1966)

Optical systems for tracking and ranging have advantages over other systems because of the inherent spatial efficiency of optical frequency energy. Plane-polarized, coherent laser beams provide a control of optical energy not previously available. Utilizing laser light, this system gives precise tracking and slant-range information at a real-time sampling rate of 200 c/s. A compound-axis servo system, made possible by a mirror system mounted on a tracking pedestal, provides angular data by tracking a laserilluminated retroreflector mounted on the target. Slant range to the retroreflector is determined by a digital-mode, frequency-modulated, cw-laser ranging system, whose resolution and sampling rate are under independent control.
New heterocyclic derivatives of benzimidazole with germicidal activity--VII--2-(5'-nitro-2'-furyl or 2'-thienyl) benzimidazoles with different substituents in the 5-position. (1990)

In continuation of our previous research, the synthesis of 13 2-(5'-nitro-2'-furyl or 2'-thienyl) benzimidazoles with different substituents in 5 position is described. The new compounds were tested in vitro against 5 (Gram+) and 4 (Gram-) strains and a mycete Candida Albicans. All the derivatives showed a certain degree of antibacterial and antimycotic activity, which in some cases was fairly good.
A High Proportion of DNA Variants of <i>BRCA1</i> and <i>BRCA2</i> Is Associated with Aberrant Splicing in Breast/Ovarian Cancer Patients (2010)

An important fraction of DNA variants of BRCA1/2 presents splicing aberrations that may represent a relevant disease-causing mechanism in HBOC. The identification of splicing disruptions by functional assays is a valuable tool to discriminate between benign polymorphisms and pathogenic mutations.
Structure of epitaxial L1-FePt/MgO perpendicular magnetic tunnel junctions (2013)

Perpendicular magnetic tunnel junctions (p-MTJs) with MgO barriers are interesting for high-density information-storage devices. Chemically ordered L10-FePt is a potential electrode due to its large perpendicular magnetocrystalline anisotropy. To-date, a single theoretical study on L10-FePt/MgO p-MTJ based on an idealized structure reported significant dependence of spin-dependent tunneling on interface structure. [Y. Taniguchi et al., IEEE Trans. Magn. 44, 2585 (2008).] We report a structural study of epitaxial L10-FePt(001)[110]//MgO(001)[110]//L10-FePt(001)[110] p-MTJs, focusing on the interfaces using aberration-corrected scanning transmission electron microscopy. Interfaces are semi-coherent, with oxygen atomic-columns of MgO located opposite to iron atomic-columns in L10-FePt. Up to three lattice planes show atomic-column steps, the origin of which is attributed to antiphase boundaries in L10-FePt.
Integrating IR and RDBMS using cooperative indexing (1995)

Article Free Access Share on Integrating IR and RDBMS using cooperative indexing Authors: Samuel DeFazio Oracle Corporation Oracle CorporationView Profile , Amjad Daoud Oracle Corporation Oracle CorporationView Profile , Lisa Ann Smith Oracle Corporation Oracle CorporationView Profile , Jagannathan Srinivasan Oracle Corporation Oracle CorporationView Profile Authors Info & Claims SIGIR '95: Proceedings of the 18th annual international ACM SIGIR conference on Research and development in information retrievalJuly 1995 Pages 84–92https://doi.org/10.1145/215206.215335Online:01 July 1995Publication History 25citation525DownloadsMetricsTotal Citations25Total Downloads525Last 12 Months9Last 6 weeks2 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
2. Photosensitized Degradation of Azo Dyes on Fe, Ti, and Al Oxides. Mechanism of Charge Transfer during the Degradation (1999)

Azo dyes disappear in photocatalyzed processes mediated by either hematite or geothite and TiO2 (anatase and rutile) under visible light irradiation. The details of the charge injection from the excited state from Orange II into the catalyst are reported by laser-pulsed spectroscopy. The electron injection from the Orange II to α-Fe2O3 occurs within the duration of the laser pulse (<10-8 s) and is followed by two processes: charge recombination with a rate of 1.1 × 107 s-1, followed by a slower process with a rate of 2.1 × 105 s-1 between the dye and the HO• radical at the iron oxide surface. At pH 3 the electrostatic attraction between FeOH2+ and HOR- leads to the formation of a strong complex between Orange II and α-Fe2O3 necessary for an efficient charge-transfer process. This interaction is seen to be much weaker at neutral pH values. The complex [Orange II···α-Fe2O3] was identified at acid pH. At a concentration of Orange II of about 2.3 mM, monolayer coverage of this dye on α-Fe2O3 was observed. Photocorrosion of α-Fe2O3 with mononolayer dye coverage is much higher than that with multilayer dye coverage under visible light irradiation. The photogenerated intermediates generated on the oxide surface by the adsorbed azo dye during irradiation were identified by FTIR and in solution by HPLC. Experimental observations with COD and BOD techniques confirmed the improved biodegradability of the intermediates generated in the presence of α-Fe2O3.
Effect of the F610A Mutation on Substrate Extrusion in the AcrB Transporter: Explanation and Rationale by Molecular Dynamics Simulations (2011)

The tripartite efflux pump AcrAB-TolC is responsible for the intrinsic and acquired multidrug resistance in Escherichia coli. Its active part, the homotrimeric transporter AcrB, is in charge of the selective binding of substrates and energy transduction. The mutation F610A has been shown to significantly reduce the minimum inhibitory concentration of doxorubicin and many other substrates, although F610 does not appear to interact strongly with them. Biochemical study of transport kinetics in AcrB is not yet possible, except for some β-lactams, and other techniques should supply this important information. Therefore, in this work, we assess the impact of the F610A mutation on the functionality of AcrB by means of computational techniques, using doxorubicin as substrate. We found that the compound slides deeply inside the binding pocket after mutation, increasing the strength of the interaction. During subsequent conformational alterations of the transporter, doxorubicin was either not extruded from the binding site or displaced along a direction other than the one associated with extrusion. Our study indicates how subtle interactions determine the functionality of multidrug transporters, since decreased transport might not be simplistically correlated to decreased substrate binding affinity.
Some Reactions of 1,4-Diselenane<sup>1</sup> (1956)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSome Reactions of 1,4-Diselenane1Edwin S. Gould and Wm. BurlantCite this: J. Am. Chem. Soc. 1956, 78, 22, 5825–5826Publication Date (Print):November 1, 1956Publication History Published online1 May 2002Published inissue 1 November 1956https://doi.org/10.1021/ja01603a029Request reuse permissionsArticle Views44Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (271 KB) Get e-Alertsclose Get e-Alerts
Detailed theory of the negative conductance of bulk negative mobility amplifiers, in the limit of zero ion density (1967)

The complex admittance behavior is calculated for a bulk negative conductivity semiconductor, such as n-type GaAs, in the limit of zero doping and zero trapping, when all electrons are due to space-charge limited emissions from the cathode. Two different approximations are used: in the first, in closed analytical form, electron diffusion is neglected; in the second, by computer simulation of the internal space-charge dynamics, it is included. Both approximations agree at low frequencies where they predict a positive device conductance. Both predict a negative conductance, of slightly different magnitude, at frequencies around the reciprocal electron transit time. At higher frequencies the diffusionless theory predicts slowly damped conductance oscillations; diffusion effects strongly increase the damping.
Biochemical Mechanisms of Cyclosporine Neurotoxicity (2004)

Proper management of chemotoxicity in transplant patients requires detailed knowledge of the biochemical mechanisms underlying immunosuppressant toxicity. Neurotoxicity is one of the most significant clinical side effects of the immunosuppressive undecapeptide cyclosporine, occurring at some degree in up to 60% of transplant patients. The clinical symptoms of cyclosporine-mediated neurotoxicity consist of decreased responsiveness, hallucinations, delusions, seizures, cortical blindness, and stroke-like episodes that mimic those clinical symptoms of mitochondrial encephalopathy. Clinical computed tomography (CT) and magnetic resonance imaging (MRI) studies have revealed a correlation between clinical symptoms of cyclosporine-mediated neurotoxicity and morphological changes in the brain, such as hypodensity of white matter, cerebral edema, metabolic encephalopathy, and hypoxic damages. Paradoxically, in animal models cyclosporine protects the brain from ischemia-reperfusion (I/R) injury. Interestingly, cyclosporine appears to mediate both neurotoxicity (under normoxic conditions) and I/R protection across the same range of drug concentration. Both toxicity and protection might arise from the intersection of cyclosporine with mitochondrial energy metabolism. This review addresses basic biochemical mechanisms of: 1) cyclosporine toxicity in normoxic brain, and 2) its protective effects in the same organ during I/R. The marked and unparallel potential of magnetic resonance spectroscopy (MRS) as a novel quantitative approach to evaluate metabolic drug toxicity is described.
TEKNOLOGI JARINGAN DALAM CLOUD COMPUTING (2009)

Cloud computing is an alternative model of the implementation and utilization of services related to Information Technology.This paradigm is touted to simplify the way procurement and purchasing IT products by the buyer, and also lighten the load shipments by vendor.However, there are a number of risks and constraints to adopt this model.In general, the definition of cloud computing is a style of computing with a large number of IT services that are scalable presented in the form of 'service' to external customers using Internet technologies.This provides an alternative to the vendors in the supply of business services supported by IT.Cloud computing contains a number of basic concepts, namely grid computing, distributed network of servers, distributed virtualization, and a series of services concept is Software as a Service (SaaS), Platform as a Service (PaaS) and Infrastructure as a Service (IaaS) , and so on which became known as the terminology XaaS.Cloud computing relies heavily on Internet technology.Therefore, the network infrastructure is one of the cores of cloud computing implementations.This paper will attempt to examine the role of technology in the implementation of cloud computing network.
Construction of High Tg Bipolar Host Materials with Balanced Electron–Hole Mobility Based on 1,2,4-Thiadiazole for Phosphorescent Organic Light-Emitting Diodes (2014)

A novel electron-transporting moiety, 1,2,4-thiadiazole, was first introduced to construct bipolar host molecules for phosphorescent organic light-emitting diodes (PhOLEDs). By incorporating 1,2,4-thiadiazole with typical hole-transporting carbazole moieties, a series of thiadiazole/carbazole hybrids, o-CzTHZ, m-CzTHZ, and p-CzTHZ, were synthesized. All the hybrids exhibit very high glass transition temperatures (Tg ≥ 167 °C) and show good thermal and morphological stability in films. Moreover, these host materials possess good bipolar charge transporting properties; electron and hole mobilities of these bipolar thiadiazole/carbazole hybrids can be tuned by simply adjusting the linkage modes between thiadiazole and carbazole moieties. The maximum external quantum efficiencies (ηEQE, max) in the green PhOLEDs with o-CzTHZ, m-CzTHZ, and p-CzTHZ as the hosts reached 26.1%, 24.0%, and 22.9%, respectively, and their EQE were still over 20% even at the high luminance of 10,000 cd/m2. This study demonstrates that 1,2,4-thiadiazole should be an excellent electron-transporting unit for bipolar phosphorescent hosts.
Clinical pharmacology of <scp>AMG</scp> 181, a gut‐specific human anti‐α<sub>4</sub>β<sub>7</sub> monoclonal antibody, for treating inflammatory bowel diseases (2014)

AMG 181 has PK/PD, safety, and effect profiles suitable for further testing in subjects with inflammatory bowel diseases.
Guanidino compounds after creatine supplementation in renal failure patients and their relation to inflammatory status (2007)

Creatine supplementation in haemodialysis patients significantly altered the concentration of specific guanidino compounds. Guanidinosuccinate correlated positively with plasma urea and negatively with inflammation markers.
Recovery of Uranium and Thorium from Graphite Fuel Elements. I. Grind-Leach Process (1960)

A grind-leach method for the recovery of uranium from high-density graphite fuel elements containing greater than 5 weight per cent uranium has been developed on a laboratory scale as a head-end treatment for standard tributyl phosphate solvent extraction processes. With fuel ground to −16 mesh, greater than 99.8% of the uranium can be recovered by leaching twice with boiling 15.8 M nitric acid. Uranium recoveries were lower with less concentrated acid, and with fuel of larger particle size or lower uranium concentration. The grind-leach method is not applicable to fuels containing less than 3% uranium. Leaching −16+30 mesh samples of a fuel containing 1.5% uranium and 7.2% thorium with either boiling 15.8 M nitric acid or 15.8 M nitric acid−0.04 M sodium fluoride, resulted in uranium and thorium recoveries of 90 and 86%, respectively.
The True Country: Themes in the Fiction of Flannery O'Connor. (1969)

Intended for a general audience as well as the scholar and student, this first full-length study of Flannery O'Connor's fiction available again in a paperback edition.
Effects of Teacher Quality of Work Life in Secondary Schools on Commitment and Sense of Efficacy∗ (1998)

ABSTRACT This paper explores the way in which teachers’ quality of work life contributes to their commitment to work and their sense of efficacy. First, a model that ties organizational characteristics of the work place to important behaviors, attitudes and psychological characteristics of teachers that effect their teaching is presented. Second, measures of quality of work life in eight schools are examined, along with the relationship between the quality of work life variables and measures of teachers’ commitment and sense of efficacy. Finally, the effects of school structure on quality of work life are examined. The data suggest that quality of work life measures are strongly associated with both dependent variables. The discussion focuses on the implications of the findings and the model for reform strategies.