gebhart/patrepeval huggingface dataset:
Guanabenz Sensitizes Pancreatic β Cells to Lipotoxic Endoplasmic Reticulum Stress and Apoptosis (2017)

Deficient as well as excessive/prolonged endoplasmic reticulum (ER) stress signaling can lead to pancreatic β cell failure and the development of diabetes. Saturated free fatty acids (FFAs) such as palmitate induce lipotoxic ER stress in pancreatic β cells. One of the main ER stress response pathways is under the control of the protein kinase R-like endoplasmic reticulum kinase (PERK), leading to phosphorylation of the eukaryotic translation initiation factor 2 (eIF2α). The antihypertensive drug guanabenz has been shown to inhibit eIF2α dephosphorylation and protect cells from ER stress. Here we examined whether guanabenz protects pancreatic β cells from lipotoxicity. Guanabenz induced β cell dysfunction in vitro and in vivo in rodents and led to impaired glucose tolerance. The drug significantly potentiated FFA-induced cell death in clonal rat β cells and in rat and human islets. Guanabenz enhanced FFA-induced eIF2α phosphorylation and expression of the downstream proapoptotic gene C/EBP homologous protein (CHOP), which mediated the sensitization to lipotoxicity. Thus, guanabenz does not protect β cells from ER stress; instead, it potentiates lipotoxic ER stress through PERK/eIF2α/CHOP signaling. These data demonstrate the crucial importance of the tight regulation of eIF2α phosphorylation for the normal function and survival of pancreatic β cells.
Using SPEM/UML profile to specification of IS development processes (2006)

Work concern using SPEM/UML profile to modeling development processes with emphasizes on project management processes. Presents SPEM capabilities and lacks, and propose SPEM extensions to facilitate modeling.
Production of Galacto-Oligosaccharides from Lactose by Immobilized β-Galactosidase (2001)

Galacto-oligosaccharides (GOS) and oligosaccharides in general have received a lot of attention recently, mainly due to their many beneficial health effects and wide applications as prebiotic food. Production of GOS from lactose by enzyme reaction is reviewed in this paper. The enzyme β-galactosidase can be used to produce GOS containing 2 to 5 galactose units and one glucose unit from lactose. Depending on the enzyme source and reaction conditions, the GOS yield varied from below 20% to as high as 67% (w/w). In general, a higher initial lactose concentration gave a wider range of GOS types produced and increased GOS yield. Reactions in an organic solvent did not increase GOS production, but rapidly inactivated the enzyme. Using a commercial enzyme from Aspergillus oryzae, a maximum GOS yield of ~71%, based on lactose reacted, was obtained at low lactose conversions (~10%), but the yield decreased with increasing lactose conversion. An integrated immobilized enzyme reactor-separator process, which continuously removes GOS from the reaction media, would give the highest possible GOS yield (>65%) from lactose. Effects of enzyme immobilization and methods to separate GOS, such as nanofiltration, are also discussed in this article.
High-throughput measurement of the Tp53 response to anticancer drugs and random compounds using a stably integrated Tp53-responsive luciferase reporter (2002)

Human Tp53 is normally a short-lived protein. Tp53 protein is stabilized and levels are increased in response to a variety of cellular stresses, including those induced by genotoxic anticancer drugs and environmental exposures. To engineer an efficient assay based on this property, we constructed and integrated a Tp53-specific reporter system into human cancer cells, termed p53R cells. We tested a range of conventional chemotherapeutic agents as well as over 16 000 diverse small compounds. Ionizing radiation and two-thirds of conventional chemotherapeutic agents, but only 0.2% of diverse compounds activated Tp53 activity by two-fold or greater, consistent with the presumptive genotoxic activation of Tp53 function. Cytotoxicity was independent of TP53 genetic status when paired, syngeneic wild-type TP53 and TP53-null cells in culture were treated with compounds that activated Tp53. From the unbiased survey of random compounds, Tp53 activation was strongly induced by an analog of AMSA, an investigational anti-cancer agent. Tp53 was also strongly induced by an N-oxide of quinoline and by dabequine, an experimental antimalarial evaluated in humans; dabequine was reported to be negative in other screens of mutagenicity and clastogenicity but carcinogenic in animal studies. Further exploration of antimalarial compounds identified the common medicinals chloroquine, quinacrine, and amodiaquine as Tp53-inducers. Flavonoids are known to have DNA topoisomerase activity, a Tp53-inducing activity that is confirmed in the assay. A reported clinical association of Tp53 immunopositive colorectal cancers with use of the antihypertensive agents was extended by the demonstration of hydralazine and nifedipine as Tp53-inducers. p53R cells represent an efficient Tp53 functional assay to identify chemicals and other agents with interesting biologic properties, including genotoxicity. This assay may have utility in the identification of novel chemotherapeutic agents, as an adjunct in the pharmaceutical optimization of lead compounds, in the exploration of environmental exposures, and in chemical probing of the Tp53 pathway.
Phosphorylated p38 and JNK MAPK proteins in hepatocellular carcinoma (2012)

Increasing p-p38 levels in HCC tissues were associated with tumour size and the formation of satellite tumours. High p-p38 expression could serve as a predictor for a poor survival for the patients with HCC. Simultaneous expression of p-JNK in HCC tissues might antagonize the promoting effect of p-p38 in human liver cancer.
Nitrofurans in Treatment of Malignant Testicular Tumors (1960)

No AccessJournal of Urology1 Jul 1960Nitrofurans in Treatment of Malignant Testicular Tumors Herbert J. Karol Herbert J. KarolHerbert J. Karol More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)65500-9AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail © 1960 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByMarshall M, Johnson S and Price S (2018) Metastatic Seminoma of Testis Treated by Oral Nitrofurazone (Furacin) and RadiotherapyJournal of Urology, VOL. 91, NO. 4, (392-395), Online publication date: 1-Apr-1964. Volume 84Issue 1July 1960Page: 120-122 Advertisement Copyright & Permissions© 1960 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Herbert J. Karol More articles by this author Expand All Advertisement Loading ...
Characterization of a Bleached Photographic Material (1972)

Experimental measurements show that the phase transmittance characteristics of a photographic material, caused by relief images and variations of refractive index, can be fairly reproducible if processing is properly controlled. To manipulate these characteristics, particularly those of bleached materials, it would be desirable to have data for the phase image corresponding to the density-log exposure curve and the MTF curve of the density image obtained by conventional processing. A method is described for obtaining both curves from measurements of optical path variation of sinusoidally exposed images. Components from both the relief image and the variation of refractive index can be determined. It is shown that such data for a bleached photographic material can be used to produce an optical path variation having an arbitrary profile.
Experimental and computational investigation of the endwall flow in a cascade of compressor blades (2000)

An investigation of the three-dimensional flow in a cascade of second-generation controlled-diffusion blades, which was as a result of the interaction of the endwall boundary layers with the blade profiles, is reported. Five-hole probe wake surveys were performed at various spanwise locations to determine the total pressure loss distribution. Downstream velocity vector information was also obtained from the five-hole probe surveys. Two-component laser-Doppler velocimetry (LDV) was used to characterize the flow in the inlet and wake regions. A numerical investigation of the flowfield was conducted using SWIFT, a computational fluid dynamics code developed by Dr. Roderick Chima of NASA Glenn Research Center. Experimental blade-surface pressure coefficients were compared with values predicted using SWIFT. Overall, good correlation between the five-hole probe and LDV measurement techniques was obtained; however, the CFD predictions did not match well with the experimental results, particularly at the midspan location of the blade where separation of the suction surface boundary layer occurred.
Signatures of quantum phase transitions in the dynamic response of fluxonium qubit chains (2015)

We evaluate the microwave admittance of a one-dimensional chain of fluxonium qubits coupled by shared inductors. Despite its simplicity, this system exhibits a rich phase diagram. A critical applied magnetic flux separates a homogeneous ground state from a phase with a ground state exhibiting inhomogeneous persistent currents. Depending on the parameters of the array, the phase transition may be a conventional continuous one, or of a commensurate-incommensurate nature. Furthermore, quantum fluctuations affect the transition and possibly lead to the presence of gapless ``floating phases.'' The signatures of the soft modes accompanying the transitions appear as a characteristic frequency dependence of the dissipative part of admittance.
Forensic determination of blood sample age using a bioaffinity-based assay (2015)

A bioaffinity-driven cascade assay was developed to determine the time elapsed from the point a blood sample was left at a crime scene to the point of discovery. Two blood markers, creatine kinase (CK) and alanine transaminase (ALT), were utilized to determine the age of the blood spot based on their natural denaturation processes. The analysis with the proposed bioassay was performed in human serum samples, which underwent the aging process under environmental conditions that could be expected at crime scenes. The concentration of the markers in the sample was based on physiological levels present in healthy adults. These two markers were concerted in a biocatalytic cascade composed of two parallel subsystems, with each of them following the activity of one marker. Both markers have very distinct denaturation rates which would not allow them to be used in a single marker setup while still providing satisfactory results. However, by parallel tunable monitoring of both markers, it is possible to provide information of the blood sample age with low temporal error for a prolonged period of time. To mimic a possible real crime scene situation – the reliability of the proposed assay was then successfully tested on dried/aged serum samples (up to 5 days old) in environments with different temperatures.
Heparan sulphate requirement in platelet-derived growth factor B-mediated pericyte recruitment (2006)

HS (heparan sulphate) plays a key role in angiogenesis, by interacting with growth factors required in the process. It has been proposed that HS controls the diffusion, and thus the availability, of platelet-derived growth factor B that is needed for pericyte recruitment around newly formed capillaries. The present paper summarizes our studies on the importance of HS structure in this regulatory process.
[Tissue distribution and deposition of clofazimine in mice following oral administration of isoniazid]. (2009)

Concomitant administration of isoniazid reduced clofazimine levels significantly in fat tissues while resulted in an increase of its level in lung tissues.
Relation of Dental Composite Formulations To Their Degradation and the Release of Hydrolyzed Polymeric-Resin-Derived Products (2001)

This article reviews the principal modes of dental composite material degradation and relates them to the specific components of the composites themselves. Particular emphasis is placed on the selection of the monomer resins, the filler content, and the degree of monomer conversion after the clinical materials are cured. Loss of mechanical function and leaching of components from the composites are briefly described, while a more detailed description is provided of studies that have considered the chemical breakdown of materials by agents that are present in the oral cavity, or model the latter. Specific attention will be given to the hydrolysis process of monomer and composite components, i.e., the scission of condensation-type bonds (esters, ethers, amides, etc.) that make up the monomer resins, following reaction of the resins with water and salivary enzymes. A synopsis of enzyme types and their sources is outlined, along with a description of the work that supports their ability to attack and degrade specific types of monomer systems. The methods for the study of biodegradation effects are compared in terms of sensitivity and the information that they provide. The impact of biodegradation on the ultimate biocompatibility of current materials is discussed from the perspective of what is known to date and what remains to be studied. The findings of the past decade clearly indicate that there are many reasons to probe the issue of biochemical stability of composite resins in the oral cavity. The challenge will now be to have both industry and government agencies take a pro-active approach to fund research in this area, with the expectation that these studies will lead to a more concise definition of biocompatibility issues related to dental composites. In addition, the acquired information from such studies will generate the development of alternate polymeric chemistries and composite formulations that will require further investigation for use as the next generation of restorative materials with enhanced biostability.
Comparison of HLA-DR1-restricted T cell response induced in HLA-DR1 transgenic mice deficient for murine MHC class II and HLA-DR1 transgenic mice expressing endogenous murine MHC class II molecules (2004)

Transgenic mice expressing human HLA class II molecules provide a useful model for identifying HLA-restricted CD4+ epitopes. However, the influence of endogenous murine H-2-restricted T cell responses on HLA-restricted responses is not known. In the present study, we show that HLA-DR1 transgenic mice deficient for H-2 class II expression (HLA-DR1+/+/IAbeta0/0) exhibit an equivalent expression level of the transgene HLA-DR1 and a similar diversity in the TCR repertoire, but a slightly different number of CD4+ peripheral T cells, when compared to HLA-DR1 transgenic mice in which H-2 class II molecules were retained (HLA-DR1+/+/IAbeta+/+). More importantly, a strong antigen-specific HLA-DR1-restricted response was observed in nearly all HLA-DR1+/+/IAbeta0/0 mice immunized with HBV envelope protein (HBs) or capsid protein (HBc), whereas weak HBs- or HBc-specific HLA-DR1-restricted responses were detected in half of the immunized HLA-DR1+/+/IAbeta+/+ mice. Conversely, strong HBs- or HBc-specific H-2-restricted T cell responses were detected in HLA-DR1+/+/IAbeta+/+ mice but not in HLA-DR1+/+/IAbeta0/0 mice. Our results indicate that the coexpression of endogenous H-2 class II molecules reduces the intensity of HLA-DR1-restricted antigen-specific responses in transgenic mice, by favoring murine over human MHC recognition and education. Thus, HLA-DR1+/+/IAbeta0/0 mice represent a better model for identifying and characterizing HLA-DR1-restricted epitopes relevant for human disease.
Inhibition of early AAA formation by aortic intraluminal pentagalloyl glucose (PGG) infusion in a novel porcine AAA model (2016)

In our model, intraluminal delivered PGG is able to penetrate the aortic wall from the inside and impair the early AAA development by stabilizing the elastic lamellae and preserving their integrity. The principle holds a high clinical potential if it can be translated to human conditions, since it, if so, potentially could represent a new drug for stabilizing small abdominal aneurysms.
A mining-based category evolution approach to managing online document categories (2005)

With rapid expansion of the numbers and sizes of text repositories and improvements in global connectivity, the quantity of information available online as free-format text is growing exponentially. Many large organizations create and maintain huge volumes of textual information online, and there is a pressing need for support of efficient and effective information retrieval, filtering, and management. Text categorization, or the assignment of textual documents to one or more pre-defined categories based on their content, is an essential component of efficient management and retrieval of documents. Previously, research has focused predominantly on developing or adopting statistical classification or inductive learning methods for automatically discovering text categorization patterns for a pre-defined set of categories. However, as documents accumulate, such categories may not capture a document's characteristics correctly. In this study, we propose a mining-based category evolution (MiCE) technique to adjust document categories based on existing categories and their associated documents. Empirical evaluation results indicate that the proposed technique, MiCE, was more effective than the category discovery approach and was insensitive to the quality of original categories.
Calibration Methods for Microwave Wafer Probing (2005)

A new level of accuracy in the measurement of microwave parasitic has been achieved, due to the combined development of microwave wafer probes and on-wafer inpedance standards. Repeatable losses and reflections in the probes can be readily removed from measured data, but radiation losses and crosstalk cannot be corrected and must be minimized. Oneport and twoport on-wafer standards for several probe footprints are shown, and their performance verified.
Quantitative Three-Dimensional Modeling of Zeotile Through Discrete Electron Tomography (2009)

Discrete electron tomography is a new approach for three-dimensional reconstruction of nanoscale objects. The technique exploits prior knowledge of the object to be reconstructed, which results in an improvement of the quality of the reconstructions. Through the combination of conventional transmission electron microscopy and discrete electron tomography with a model-based approach, quantitative structure determination becomes possible. In the present work, this approach is used to unravel the building scheme of Zeotile-4, a silica material with two levels of structural order. The layer sequence of slab-shaped building units could be identified. Successive layers were found to be related by a rotation of 120 degrees, resulting in a hexagonal space group. The Zeotile-4 material is a demonstration of the concept of successive structuring of silica at two levels. At the first level, the colloid chemical properties of Silicalite-1 precursors are exploited to create building units with a slablike geometry. At the second level, the slablike units are tiled using a triblock copolymer to serve as a mesoscale structuring agent.
'WearCam' (The wearable camera): personal imaging systems for long-term use in wearable tetherless computer-mediated reality and personal photo/videographic memory prosthesis (2002)

The purpose of this paper is to disclose the operational principles of 'WearCam', the basis for wearable tetherless computer-mediated reality both in its idealized form, as well as in some practical embodiments of the invention, including one of its latest embodiments. The specific inner workings of WearCam, in particular; details of its optical arrangement, have not previously been disclosed, other than by allowing a small number of individuals to look inside the glasses. General considerations, background, and relevant findings, in the area of long-term use of wearable, tetherless computer-mediated reality are also presented. Some general insight (arising from having designed and built more than 100 different kinds of personal imaging systems over the last 20 years) is also provided. Unlike the artificiality of many controlled laboratory experiments, much of the insight gained from these experiences relates to the natural complexity of real-life situations.
Magnetic backprojection imaging of the vascular lumen (1995)

Current injected into a phantom model generated a magnetic field which was distorted above a simulated atherosclerotic lesion. The output of a Hall effect magnetic sensor was used in a backprojection to reconstruct the centroid of the simulated blood flow and thus localize the modeled atherosclerotic plaque region.
Cycloamylose as an efficient artificial chaperone for protein refolding (2000)

High molecular weight cyclic alpha-1,4-glucan (referred to as cycloamylose) exhibited an artificial chaperone property toward three enzymes in different categories. The inclusion properties of cycloamylose effectively accommodated detergents, which keep the chemically denatured enzymes from aggregation, and promoted proper protein folding. Chemically denatured citrate synthase was refolded and completely recovered it's enzymatic activity after dilution with polyoxyethylenesorbitan buffer followed by cycloamylose treatment. The refolding was completed within 2 h, and the activity of the refolded citrate synthase was quite stable. Cycloamylose also promoted the refolding of denatured carbonic anhydrase B and denatured lysozyme of a reduced form.
Pulmonary artery denervation: a novel treatment modality for pulmonary hypertension (2019)

Pulmonary arterial hypertension (PAH) is a complex pulmonary vascular disease that leads to right ventricular (RV) failure and sudden cardiac death (1). PAH is associated with sympathetic nervous system (SNS) over-stimulation, renin-angiotensin-aldosterone system (RAAS) activation and cardiac arrhythmias. RAAS activation generates vasoactive compounds that result in pulmonary vasoconstriction and vascular remodeling, hallmarks of PAH (2). It is suggested that patients with PAH often have a low cardiac output and that RAAS and SNS over-activation are merely compensatory mechanisms for that decreased cardiac output (3).
New deployable truss concepts for large antenna structures or solar concentrators (1991)

Covers advancements in spacecraft and tactical and strategic missile systems, including subsystem design and application, mission design and analysis, materials and structures, developments in space sciences, space processing and manufacturing, space operations, and applications of space technologies to other fields.
High Photoconductive Vertically Oriented TiO<sub>2</sub> Nanotube Arrays and Their Composites with Copper Phthalocyanine (2008)

Size-controllable and vertically oriented TiO2 nanotube arrays were fabricated by using anodic oxidation of pure titanium sheets in electrolyte solutions and were characterized by field-emission scanning electron microscope (FESEM), transmission electron microscope (TEM), and X-ray diffraction (XRD). A double-layered photoconductive device (Au/copper phthalocyanine/TiO2 nanotubes/titanium) was designed and fabricated based on the TiO2 nanotube arrays. The I−V curves demonstrated typical heterojunction characteristics and remarkable photoconductive performance for the devices. The effect of the thickness of copper phthalocyanine (CuPc) and the diameter of TiO2 nanotubes on the photoconductive property of devices was studied. The current value increased by 2 or 3 orders of magnitude when exposed to light from the dark, depending on the thickness of the CuPc layer and the diameter of TiO2 nanotubes.
Bibliographie des lettres canadiennes-françaises (1965)

Le Centre de documentation des lettres canadiennes-franaises a dress, pour le prsent numro, la bibliographie des volumes parus en librairie du 1 er