gebhart/patrepeval huggingface dataset:
Comparative aspects of implantation (2009)

Uterine receptivity to implantation of blastocysts in mammals includes hatching from zona pellucida, precontact with uterine luminal (LE) and superficial glandular (sGE) epithelia and orientation of blastocyst, apposition between trophectoderm and uterine LE and sGE, adhesion of trophectoderm to uterine LE/sGE, and, in some species, limited or extensive invasion into the endometrial stroma and induction of decidualization of stromal cells. These peri-implantation events are prerequisites for pregnancy recognition signaling, implantation, and placentation required for fetal-placental growth and development through the remainder of pregnancy. Although there is a range of strategies for implantation in mammals, a common feature is the requirement for progesterone (P(4)) to downregulate expression of its receptors in uterine epithelia and P(4) prior to implantation events. P(4) then mediates its effects via growth factors expressed by stromal cells in most species; however, uterine luminal epithelium may express a growth factor in response to P(4) and/or estrogens in species with a true epitheliochorial placenta. There is also compelling evidence that uterine receptivity to implantation involves temporal and cell-specific expression of interferon (IFN)-stimulated genes that may be induced directly by an IFN or induced by P(4) and stimulated by an IFN. These genes have many roles including nutrient transport, cellular remodeling, angiogenesis and relaxation of vascular tissues, cell proliferation and migration, establishment of an antiviral state, and protection of conceptus tissues from challenges by the maternal immune cells.
Managing performance using weighted round-robin (2002)

IP networks will evolve from today's best-effort Internet into multi-class networks supporting quality of service requirements of diverse applications. This paper addresses one of the challenges of these new IP networks: how to set control parameters to deliver differentiated performance. We study this problem in a simplified setup of a single link and a weighted round robin queueing discipline. After giving an exact formulation of the problem, we apply an approximation of the waiting times to gain insight into the feasible performance and behavior of service limits as a function of the traffic parameters. The methodology is illustrated with several numerical examples.
Viability of using near infrared PbS quantum dots as active materials in luminescent solar concentrators (2010)

The performance of chemically synthesized lead sulfide (PbS) quantum dots (QDs) in planar, nontracking luminescent solar concentrators (LSCs) is evaluated using spectroscopic and photovoltaic techniques. Spatially resolved measurements are used to investigate and analyze the role of reduced self-absorption on the LSC efficiency. From comparative measurements of samples with Rhodamine B and CdSe/ZnS QDs it is established that PbS LSCs generate nearly twice the photocurrent in silicon cells than the other materials, achieving an integrated optical efficiency of 12.6%. This is attributed primarily to the broadband absorption of PbS which allows optimum harvesting of the solar spectrum.
Graphene-doped photo-patternable ionogels: tuning of conductivity and mechanical stability of 3D microstructures (2012)

This work reports for the first time the development of enhanced-conductivity, graphene-doped photo-patternable hybrid organic-inorganic ionogels and the effect of the subsequent materials condensation on the conductivity and mechanical stability of three-dimensional microstructures fabricated by multi-photon polymerisation (MPP). Ionogels were based on photocurable silicon/zirconium hybrid sol–gel materials and phosphonium (trihexyltetradecylphosphonium dicyanamide) [P6,6,6,14][DCA] ionic liquid (IL). To optimise the dispersion of graphene within the ionogel matrices, aqueous solutions of graphene were prepared, as opposed to the conventional graphene powder approach, and employed as catalysts of hydrolysis and condensation reactions occurring in the sol–gel process. Ionogels were prepared via a two step process by varying the hydrolysis degree from 25 to 50%, IL content between 0–50 w/w%, and the inorganic modifier (zirconate complex) concentration from 30 to 60 mol.% against the photocurable ormosil and they were characterised via Raman, Electrochemical Impedance Spectroscopy and Transmission Electron Microscopy. MPP was performed on the hybrid ionogels, resulting in three-dimensional microstructures that were characterised using scanning electron microscopy. It is clearly demonstrated that the molecular formulation of the ionogels, including the concentration of graphene and the zirconate network modifier, plays a critical role in the conductivity of the ionogels and influences the resulting mechanical stability of the fabricated three-dimensional microstructures. This work aims to establish for the first time the relationship between the molecular design and condensation of materials in the physico-chemistry and dynamic of ionogels.
Multi-domain autonomous mobile network for Sensing (2016)

Multi-domain autonomous sensor networks are essential for reducing capability gaps between different kinds of sensing platforms. Design of an efficient network can provide seamless sensing capability. Furthermore, to achieve operational persistency, nodes of the networks are required to be robust and affordable. Field robotics has other challenges in addition to robustness and in particular the logistics cost is one of them. Hence, the flexibility to be able to reconfigure the structure of a vehicle in the field significantly reduces transportation of additional items. In this study our group presents our current robotic fleet's strength and the systems that have been developed in the recent years aiming to answer these challenges.
Structure−Activity Relationship Studies of Gonadotropin-Releasing Hormone Antagonists Containing<i>S</i>-Aryl/Alkyl Norcysteines and Their Oxidized Derivatives (2007)

A series of acyline analogues incorporating l- and d-isomers of S-arylated/alkylated norcysteines [Ncy(R), where R is 2-naphthyl, methyl, and isopropyl] at positions 1, 4, 7, and 10 were synthesized. Some of these analogues were mono- and dioxidized to sulfoxides and sulfones. All of the analogues of acyline were screened for the antagonism of the GnRH-induced response in a reporter gene assay in HEK-293 cells expressing the human GnRH receptor. Nine of the analogues (9, 11, 15, 16, 17, 19, 20, 21, and 22) had antagonistic potency (IC50 < 2 nM) similar to that of acyline (IC50 = 0.52 nM) in this assay. Selected analogues (9, 11, 15, 16, 19, and 21) were tested in vitro for their antagonism at the rat GnRH-R in a reporter gene assay as well as in an in vivo intact male rat assay. Analogues 9 and 15 were the most potent in suppressing testosterone levels.
Millimeter-Wave Integrated Circuits (1968)

Monolithic millimeter-wave integrated circuits have been designed and fabricated on semi-insulating GaAs substrates using microstrip transmission lines. Circuits using hybrid techniques have also been constructed on quartz and ceramics. This paper shows that microstrip-line integrated circuits are feasible at millimeter-wave frequencies. Circuit functions have been constructed and tested in the 25- to 100-GHZ range. The loss in microstrip line on semi-insulating GaAs was found to be less than 0.3 dB//lambda/. Couplers from waveguide to microstrip have been made with transmission losses less than 0.5 dB. Monolithic integrated detectors showed 5-dB better sensitivity than a 1N53 diode in a Philips detector mount. Monolithic diodes delivered 1.5 mW at 28 GHz. The results are encouraging and a fully monolithic integrated receiver is under development.
Role of undecaprenyl phosphate in synthesis of polymers containing sialic acid in Escherichia coli. (1975)

Membrane-associated sialytransferase complexes from Escherichia coli K-235 catalyze the incorporation of N-acetylneuraminic acid (NeuNAc) from cytidine 5-monophospho-N-acetylneuraminic acid (CMP-NeuNAc) into polymeric products and a lipid fraction. Reconstitution of enzyme activity in lipid-depleted membrane complexes had an absolute dependence on a purified phospholipid which was characterized by high resolution mass spectrometry following dephosphorylation as undecaprenol. An identical mass spectrum was obtained on the phosphorylated lipid confirming that the active derivative was undecaprenyl phosphate. This C55-isoprenoid alcohol accounted for 95% of the polyisoprenol and contained 11 isoprene units, each one unsaturated. The remaining 5% was composed of the C60 homologue, dodecaprenol. Ficarprenyl phosphate, an isomer of undecaprenyl phosphate, also restored enzymatic activity although on a molar basis, it was less active than undecaprenyl phosphate. These results provide direct evidence that sialyl polymer synthesis has an obligatory requirement for undecaprenyl phosphate, a membrane-bound lipid coenzyme which functions as an intermediate carrier of glycosyl residues in the biosynthesis of a variety of microbial cell surface polysaccharides. These data extend further the general class of polysaccharides whose synthesis involves undecaprenyl phosphate and are in accord with the hypothesis that this lipid acts as an intermediate carrier of sialyl residues in sialyl polymer synthesis according to the following reaction: CMP-NeuNAc plus P-undecaprenol in equilibrium NeuNAc-P-undecaprenol plus CMP Although the sialylated lipid remains to be characterized, evidence in support of this conclusion was obtained by kinetic analysis of N-acetylneuraminic acid transfer into the lipid soluble fraction and sialyl polymers. These studies showed a rapid incorporation of N-acetylneuraminic acid into the lipid-soluble fraction prior to maximal sialyl polymer formation, an observation consistent with a possible precursortion, an observation consistent with a possible precursor-product relationship. Confirmation that the radioactivity in the lipid-soluble fraction was lipid-linked N-acetylneuraminic acid was provided by the demonstration of the formation of a transitory sialyl-lipid with chromatographic properties expected of sialyl-undecaprenyl phosphate. Three additional lines of investigation implicated a functional role for undecaprenyl phosphate in sialyl polymer synthesis...
A dot-immunobinding assay on nitrocellulose with psoralen inactivated Herpesvirus simiae (B virus). (1987)

An enzyme-immunoassay performed with Herpesvirus simiae (B virus) and H. simplex antigens inactivated with a psoralen derivative and long-wavelength ultraviolet light irradiation is described. Although B virus is a known human pathogen requiring extreme care in its handling, the use of inactivated antigens in the test allows its performance without biosafety containment. The test utilizes nitrocellulose sheets dotted with antigen for the assay of antibody against B virus in nonhuman primate sera. Antigen-antibody complexes are detected visually as red dots by the use of enzyme-conjugated antiglobulin second antibody and a substrate that produces an insoluble product. The test is more rapid, sensitive and specific than the serum neutralization test it is intended to replace. Of 150 macaque monkey sera tested, 83 were negative by the enzyme and neutralization tests, 56 were positive by both tests and 11 were positive by enzyme-assay but negative by neutralization. Positive sera reacted with both simian and human viral antigens in the enzyme assay but with greater intensity against B virus. Absorption with H. simplex removes reactivity with this virus without reducing the B virus response.
Stability of Insulin Preparations (1972)

The stability of seven types of pharmaceutical insulin preparations was determined by a bioassay (mouse convulsion method) and a radioimiminoassay after storage for different periods at 4° C., 15° C., 25° C., 37° C., or 45° C. in the dark. The seven insulin preparations were: Ordinary Insulin, Protamine Zinc Insulin (PZI), the Lente insulins (Ultralente, Semilente and Lente), Rapitard and Aetrapid. Full biological potency was registered in all the insulin preparations under study after five years of storage at 4° C. The biological potency (P(t,T)) as function of time (t) and absolute temperature (T) can be expressed by the formula: Using the values observed, the constants P0 (initial potency), α, and β were calculated for each type of insulin preparation. According to the formulas the loss in biological potency for all the insulin preparations will be less than 10 per cent after storage for sixty-nine years at 5° C., ten years at 15° C., twenty months at 25° C., three months at 35° C. or ten days at 45° C. The activation energy (Ea), the half-life (t0.5) and the temperature coefficient (Q10) were calculated for each of the seven insulin preparations using α and β. The rate of disappearance of biological insulin activity was found to increase four- to fifteenfold with a temperature increase- of 10° C. The decline in inmiunological activity was less than that in biological activity, especially in cases where the loss in biological potency was substantial. It is concluded that the immunoassay is no reliable substitute for the bioassay of unknown insulin preparations.
A strategy for efficient handling of fresh tumor needle biopsies that allows histological and cytopathological assessment (2008)

Neo-adjuvant chemotherapy prior to surgery is used in the management of many pediatric solid tumors, and diagnosis is therefore valuable and is frequently made by percutaneous needle biopsy. We describe a method that enhances tissue preservation and obtains a sample for rapid cytopathological assessment. Biopsies are placed in Ham's F(10) culture's medium in theatre and transferred to pathology. The biopsies are retrieved from the medium and dealt as before (submit to cytogenetics; fix in glutharaldheyde; snap frozen at -80 degrees C and routine histology). An equal amount of 90% alcohol is then added to the Ham culture's medium fluid received from theatre before performing a cytospin preparation and a cell clot. We used this method in the diagnosis of 16 tumors demonstrating that this allows a more efficient handling of the biopsy, makes possible a same day diagnosis, enhances the quality of the immunohistochemistry and maximizes the amount of tissue available for diagnosis.
Tetrahydrofuryl Amino Alcohols (1943)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTetrahydrofuryl Amino AlcoholsAlfred Burger and Grant H. HarnestCite this: J. Am. Chem. Soc. 1943, 65, 12, 2382–2383Publication Date (Print):December 1, 1943Publication History Published online1 May 2002Published inissue 1 December 1943https://pubs.acs.org/doi/10.1021/ja01252a039https://doi.org/10.1021/ja01252a039research-articleACS PublicationsRequest reuse permissionsArticle Views297Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The oxidase and dehydrogenase systems of the crystalline style of Mollusca (1933)

THE occurrence in the crystalline style of Saxidomus giganteus, Paphia staminea and Mya arenaria of substances having the general properties of enzymes and capable of oxidising some of the reagents commonly employed for the detection of oxidases was recorded in a previous paper [Berkeley, 1923]. Similar sub- stances have since been found in the style of Pecten maximus, Mytilus edulis, Ostrea edulis Ensis siliqua
International symposium on the role of lycopene and tomato products in disease prevention. (1997)

cavity, pharynx, and esophagus; 0.43 (95% CI, 0.3-0.6) for stomach; 0.39 (95% CI, 0.3-0.5) for colon; and 0.42 (95% CI, 0.3-0.6) for rectal cancer. In a follow-up study based on 1953 cases and 4154 controls that was conducted between 1992 and 1996 with a more detailed food questionnaire, the protective effect of tomato consumption for colorectal cancer was confirmed, even when it was adjusted for confounders such as body mass index, caloric intake, and physical activity, giving ORs for the highest consumption quintile of 0.79 (95% CI, 0.6-0.9) for colon cancer and 0.71 (95% CI, 0.5-0.9) for rectal cancer. Whereas the studies in the United States had indicated that the highest protective effect is
Growth Characteristics of Brewery Microorganisms in a Modified Nutrient Medium (1966)

(1966). Growth Characteristics of Brewery Microorganisms in a Modified Nutrient Medium. Proceedings. Annual meeting - American Society of Brewing Chemists: Vol. 24, Proceedings of the Annual Meeting 1966, pp. 58-63.
Fast algorithm for a near-field synthetic aperture radar processor (1994)

A radar image can be formed by coherently integrating the backscattered fields over the measured frequency band and cross-range scan. This coherent integration can be seen as a convolution of the measured data and a focusing function, which only depends on the geometry of the measurement. Thus, by applying fast Fourier transform (FFT) techniques and computing a product in the Fourier domain one can efficiently reconstruct the target image. On the other hand, in the particular case of indoor synthetic aperture radar (SAR) measurements with the same geometry, the focusing operator must be computed just once and may be reused when processing the different datasets, reducing drastically the computing time.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Automated Fault Location System for Primary Distribution Networks (2005)

This paper presents the development, simulation results, and field tests of an automated fault location system for primary distribution networks. This fault location system is able to identify the most probable fault locations in a fast and accurate way. It is based on measurements provided by intelligent electronic devices (IEDs) with built-in oscillography function, installed only at the substation level, and on a database that stores information about the network topology and its electrical parameters. Simulations evaluate the accuracy of the proposed system and the experimental results come from a prototype installation.
Electrogram patterns predicting successful catheter ablation of ventricular tachycardia. (1988)

Ventricular tachycardia in patients with remote myocardial infarction is thought to be due to reentry. To improve the efficacy of catheter ablation, we sought to identify electrograms identifying essential components of the reentrant circuit. In this study we compared the efficacy of shocks delivered at sites of early ventricular activation during tachycardia (presumably exit sites from the reentrant circuit) with that of shocks delivered at sites recording mid-diastolic potentials that were not continuous with the main ventricular potential recorded during the QRS complex, but that always remained associated with the tachycardia during initiation, termination, and resetting with extrastimuli (presumably activation of a segment of the slowly conducting region of the reentrant circuit). A total of 20 attempts was made to ablate 14 monomorphic ventricular tachycardias in 10 patients with remote myocardial infarction with use of one to five shocks of 50 to 370 J (200 J in 70%). All seven tachycardias in which isolated mid-diastolic potentials were targeted were successfully ablated, although one required a second attempt. Twelve attempts were made to ablate seven tachycardias by delivering shocks at sites of early activation during tachycardia when mid-diastolic potentials were not identified. Only three attempts (25%) were successful. Activation preceded the QRS complex by 60, 85, and 120 msec in the three successful attempts and by 20 to 110 msec (median 55 msec) in the nine unsuccessful attempts. For the total 20 attempts, there was no significant difference between successful and nonsuccessful ablation in the number of shocks or total energy delivered.(ABSTRACT TRUNCATED AT 250 WORDS)
Cathepsin S and an asparagine-specific endoprotease dominate the proteolytic processing of human myelin basic proteinin vitro (2001)

The biochemical characterization of antigen degradation is an important basis for a better understanding of both the immune response and autoimmune diseases mediated by MHC class II molecules. In this study we used high-performance liquid chromatography and mass spectrometry to analyze the processing of myelin basic protein (MBP), a potential autoantigen implicated in the pathogenesis of multiple sclerosis. We resolved the kinetics of MBP processing by lysosomal extracts or purified endocytic proteases, identified the major cleavage sites during this process and assigned them to the activity of proteolytic enzymes. Proteolytic processing of MBP is mostly guided along the hydrophobic regions of the protein. It is initiated by two proteolytic steps (after N(92) and S(110)) that are performed by an asparagine-specific endopeptidase (AEP) and by cathepsin (Cat) S, respectively. The resulting processing intermediates are converted into more than 60 different species of 20-40-mers due to the activity of endopeptidases including CatS, D and L. The fragments thus generated are subsequently degraded by C- or N-terminal trimming. Strikingly, the initial cleavages during MBP processing affect two immunodominant regions of the potential autoantigen [MBP(85-99) and MBP(111-129)] in an inverse manner. CatS directly generates the N terminus of the epitope MBP(111-129) in large quantities during the initial phase of processing, which might explain the immunogenicity of this region in spite of its relatively poor binding to HLA-DR4. In contrast, the dominant cleavage by AEP mediates the destruction of MBP(85-99) unless the epitope is protected, e.g. by binding to HLA-DR. Our results thus characterize the proteolytic events during processing of MBP on a molecular level and suggest a biochemical basis for the immunogenicity of the immunodominant epitopes, which could serve as a guideline for future therapeutic strategies.
Alexander Campbell as a Publisher (1995)

Holloway, Gary (1995) "Alexander Campbell as a Publisher," Restoration Quarterly: Vol. 37 : No. 1. This repository hosts selected Restoration Quarterly articles in downloadable PDF format. For the benefit of users who would like to browse the contents of RQ, we have included all issue covers even when full-text articles from that issue are unavailable. All Restoration Quarterly articles are available in full text in the ATLA Religion Database, available through most university and theological libraries or through your local library’s inter-library loan service.