gebhart/patrepeval huggingface dataset:
Nutlin3 Blocks Vascular Endothelial Growth Factor Induction by Preventing the Interaction between Hypoxia Inducible Factor 1α and Hdm2 (2007)

Hdm2 is elevated in numerous types of malignancies and is thought to impede the function of wild-type p53. Reactivation of p53 by disrupting the association with Hdm2 was the impetus for the development of Nutlin3. Although regulation of p53 has been the central focus of Hdm2 activity, it also binds other proteins through its p53-binding domain. Here, we show that hypoxia-inducible factor 1alpha (HIF1alpha) binds to Hdm2 in the domain designated to bind p53. HIF1alpha and p53 share a conserved motif that is required to bind Hdm2. Distinct complexes form between Hdm2-HIF1alpha and Hdm2-p53 as determined by immunoprecipitation of nuclear extracts and in vitro. The Hdm2 antagonist Nutlin3 prevents the association between Hdm2 and HIF1alpha. The vascular endothelial growth factor (VEGF) gene is a transcriptional target of HIF1alpha, and under normoxic or hypoxic conditions, Hdm2 increases HIF1alpha activity to induce VEGF production. Blocking the association of Hdm2 and HIF1alpha by Nutlin3, or ablating Hdm2 expression, diminished the level of VEGF under conditions of normoxia or hypoxia. Our findings establish a unique role for Nutlin3 in attenuating VEGF induction by preventing the association of Hdm2 with HIF1alpha.
Hepatic artery infusion of antisense oligodeoxynucleotide and lipiodol mixture transfect liver cancer in rats (2005)

ASODN can transfect Walker-256 cells. ASODN mixed with lipiodol infusion via hepatic artery can be used in the treatment of HCC.
Severe Staphylococcus aureus Infections Caused by Clonally Related Community-Acquired Methicillin-Susceptible and Methicillin-Resistant Isolates (2003)

We investigated the genetic relatedness of 5 community-acquired (CA) Staphylococcus aureus isolates obtained from 4 consecutive pediatric patients presenting with sepsis syndrome and severe pneumonia during a 3-week period in 2000. Two patients were infected with methicillin-susceptible S. aureus (MSSA), and 2 were infected with methicillin-resistant S. aureus (MRSA). The pulsed-field gel electrophoresis patterns for the 2 CA-MRSA isolates were identical to each other, as were the patterns for the 3 CA-MSSA isolates. A 2-band difference reflecting the presence of a staphylococcal cassette chromosome mec (SCCmec) element distinguished the CA-MRSA isolates from the CA-MSSA isolates. The small, mobile type IV SCCmec element was present in the CA-MRSA isolates. These data suggest that an insertion or, less likely, a deletion of the SCCmec type IV element occurred in a highly virulent S. aureus background. Staphylococcal toxin genes sea, seh, lukS-PV, and lukF-PV were detected in all isolates. Also, in all isolates, was a partial homolog of seo (seo'). The relationship among these patient isolates strengthens the assumption that CA-MRSA infections may be caused by isolates closely related to MSSA isolates.
Experimental Exposure of Broiler Chickens to Boric Acid to Assess Clinical Signs and Lesions of Toxicosis (1992)

One-day-old broiler chicks were housed on litter treated with 0, 0.9, 3.6, or 7.2 kg of boric acid per 9.3 m2 of floor space. After 15 days, average body weights were 340.7 g, 278.1 g, and 213.2 g for chickens exposed to 0, 3.6, and 7.2 kg boric acid/9.3 m2, respectively (P < or = 0.05). Feed conversion was 1.68 and 2.29 in chickens exposed to 0 and 7.2 kg boric acid/9.3 m2 (P < or = 0.05). In a second experiment, after birds ingested feed treated with 2500 and 5000 ppm of boric acid for 2 weeks, body weights were 254.8 g and 149.6 g, respectively. The chickens in the control group weighed an average of 285.0 g (P < or = 0.05). The 5000 ppm treatment group had a feed conversion of 1.70, vs. 1.45 in the controls (P < or = 0.05). A dose-related feathering abnormality was evident in treated chickens. No significant histopathologic changes were observed. Livability, weight gain, and feed conversion were not adversely affected in broilers as a result of exposure to litter treated with boric acid at recommended levels of 0.4-0.9 kg/9.3 m2.
Klotho Depletion Contributes to Increased Inflammation in Kidney of the <i>db/db</i> Mouse Model of Diabetes via RelA (Serine)536 Phosphorylation (2011)

These findings suggest that Klotho serves as an anti-inflammatory modulator, negatively regulating the production of NF-κB-linked inflammatory proteins via a mechanism that involves phosphorylation of Ser(536) in the transactivation domain of RelA.
Progress toward Device-Quality Second-Order Nonlinear Optical Materials. 1. Influence of Composition and Processing Conditions on Nonlinearity, Temporal Stability, and Optical Loss (1998)

We report the incorporation of a new trifunctionalized disperse red-type chromophore into a polyurethane thermosetting system. Six polymers with different chromophore loading and NCO/OH ratios were synthesized. This system exhibited very good poling efficiencies, and the optimum chromophore loading density ranged from 30 to 40%. Decreasing chromophore loading caused an attenuation of macroscopic nonlinearity, due to the lowering of chromophore concentration in the polymer; while increasing chromophore loading above 40% also attenuated the nonlinearity, presumably because of chromophore−chromophore electrostatic interactions starting to compete with the electric field−chromophore dipole interactions at high chromophore concentration. Materials with a NCO/OH ratio equal to or greater than unity have much higher temporal stability of dipole alignment than materials with a NCO/OH ratio less than 1. By anchoring the chromophores at both the donor and acceptor ends, the temporal stability of dipole alignment was enhanced significantly. For such materials, the optical loss of unpoled materials with nonstoichiometric NCO/OH ratios was observed to be high; however, this loss could be reduced to less than 1 dB/cm by adjusting the NCO/OH ratio to unity. It is generally believed that poling induced optical loss is a serious problem associated with second-order NLO materials prepared by electric field poling. In our study, we found this type of optical loss could be reduced to only 0.2 dB/cm by careful control of processing conditions.
Intraspecific <i>ITS</i> Variability in the Kingdom <i>Fungi</i> as Expressed in the International Sequence Databases and Its Implications for Molecular Species Identification (2008)

The internal transcribed spacer (ITS) region of the nuclear ribosomal repeat unit is the most popular locus for species identification and subgeneric phylogenetic inference in sequence-based mycological research. The region is known to show certain variability even within species, although its intraspecific variability is often held to be limited and clearly separated from interspecific variability. The existence of such a divide between intra- and interspecific variability is implicitly assumed by automated approaches to species identification, but whether intraspecific variability indeed is negligible within the fungal kingdom remains contentious. The present study estimates the intraspecific ITS variability in all fungi presently available to the mycological community through the international sequence databases. Substantial differences were found within the kingdom, and the results are not easily correlated to the taxonomic affiliation or nutritional mode of the taxa considered. No single unifying yet stringent upper limit for intraspecific variability, such as the canonical 3% threshold, appears to be applicable with the desired outcome throughout the fungi. Our results caution against simplified approaches to automated ITS-based species delimitation and reiterate the need for taxonomic expertise in the translation of sequence data into species names.
Dye-doped step-index polymer optical fiber for broadband optical amplification (1996)

We report the development of a novel and simple technique for fabricating polymer optical fibers of good optical quality for special device applications. This technique aims at polymer fibers doped with various functional organic materials. On the basis of the technique, step-index polymer optical fibers doped with laser dyes have been fabricated. High-gain and high-efficiency optical amplification has been achieved in a Rhodamine B-doped polymer fiber with a low pump power of less 1 kW and pulse width 5 ns. Because a high dye concentration is used, the optimal wavelength range of optical amplification in this fiber is significantly red-shifted toward the center of the communication window (at 650 nm wavelength) of methyl methacrylate-based polymer optical fiber. The shift is from the originally 560 and 590 nm to presently 610 to 640 nm. We also present experimental results that show good photostability of the Rhodamine B-doped polymer fiber, compared with those recently reported in the improved polymer material systems. From the experimental observation, we identified the thermally induced bleach of dye molecules as the major contributing factor to the lifetime of our material system.
Clinical Trials in Traumatic Brain Injury: Lessons for the Future (2003)

Thus far, none of the neuroprotective drugs that have been tested to reduce or prevent secondary ischemic brain damage have been shown clear benefit. We will attempt to identify factors that may be responsible for some of these failures. We also will give our thoughts on how to prevent these pitfalls in the usefulness and criteria for use of animal models for traumatic brain injury to depict human head injury are discussed. Clearly, mechanism-driven trials, in which individual pathophysiological mechanisms are targeted, are more likely to show benefit in this heterogeneous patient population. Other factors, such as the effect of brain penetration, safety and tolerability of the compound, and the interface between the pharmaceutical industry and academics are a major influence in the success of these trials. Furthermore, the way trials have been analyzes in the past may not always have been be the most appropriate to show benefits. It is clear that a multi-targeted approach is necessary to address the complicated and closely related mechanisms seen after traumatic and or ischemic brain damage.
Automated Negotiations: A Survey of the State of the Art. (1997)

This paper provides a definition of automated negotiation within electronic commerce. It outlines two barriers to automated negotiation, the ontology issue and the strategy problem. State of the art overviews are given of automated negotiation, specifically Negotiation Support Systems, intelligent agents, the auction mechanism, and online marketspaces. Both academic research and currently functional systems are covered, and several World Wide Web addresses are given for readers who wish to investigate further on their own. 1 1 While every attempt is made to provide current URL locations, the Web changes more quickly than print media can ever capture. Hence, some of the URLs may not be current or correct by the time this article appears. We will try to keep our Negotiation Project web site, http://haas.berkeley.edu/~citm/nego-proj.html, current with respect to these addresses. 2 1.
Client-server challenges for digital video (2003)

The various challenges faced in delivering interactive digital video services to desktop computers in local area environments are discussed. Similar to well-known data applications, most video applications of interest involve sharing digital video information stored in a server through a local area network. Given the unique requirements of video services (large volumes of data, continuous-stream nature of the traffic, and high aggregate bandwidth), supporting such services over existing local area networks and using existing network file servers are severely limited by a number of bottlenecks present in these environments. Following a brief discussion of the unique requirements of video services, the bottlenecks in question are identified and discussed in view of rendering digital video applications economically feasible.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
“戴姆勒-克莱斯勒”公司欧洲总部办公大楼采用LonWorks技术 (2007)

戴姆勒-克莱斯勒集团公司耗资6500万欧元（合6.5亿人民币）,在华沙新建了一座宏伟的办公大楼。这座大楼是戴姆勒-克莱斯勒汽车公司欧洲总部的所在地,梅塞得斯-奔驰汽车的旗舰店和展示厅也设在这里。这座带有九层圆形塔式大楼的宏伟建筑物,成为戴姆勒-克莱斯勒这个世界著名汽车制造公司的形象展示。
Virus transport in unsaturated porous media (2000)

A numerical model for one‐dimensional virus transport in homogeneous, unsaturated porous media was developed. The model accounts for virus sorption onto liquid‐solid and air‐liquid interfaces as well as inactivation of viruses suspended in the liquid phase and viruses attached at both interfaces. The effects of the moisture content variation on virus transport in unsaturated porous media were investigated. In agreement with previous experimental studies, model simulations indicated that virus sorption is greater at air‐liquid than liquid‐solid interfaces. Available data from experiments of colloid transport through unsaturated columns were successfully simulated by the virus transport model developed in this study.
Room-temperature operation of an InGaAsP double-heterostructure laser emitting at 1.55 μm on a Si substrate (1990)

The room-temperature operations of an InGaAsP double-heterostructure (DH) laser emitting at 1.55 μm on a Si substrate is reported. A pulsed threshold current as low as 46 mA has been measured for a ridge waveguide laser with a 4 μm strip width and a 200 μm cavity length. This successful laser operation is due to the high crystalline quality of the DH structure with full width at half maximum of x-ray rocking curves as low as 110 arcsec grown on a Si substrate by the organometallic vapor phase epitaxy/vapor mixing epitaxy hybrid method. A correlation between the optical property of an InGaAsP DH and its crystalline quality is also discussed.
Synthesis, Characterization, and Reactivity of Fe Complexes Containing Cyclic Diazadiphosphine Ligands: The Role of the Pendant Base in Heterolytic Cleavage of H<sub>2</sub> (2012)

The iron complexes CpFe(P(Ph)(2)N(Bn)(2))Cl (1-Cl), CpFe(P(Ph)(2)N(Ph)(2))Cl (2-Cl), and CpFe(P(Ph)(2)C(5))Cl (3-Cl)(where P(Ph)(2)N(Bn)(2) is 1,5-dibenzyl-1,5-diaza-3,7-diphenyl-3,7-diphosphacyclooctane, P(Ph)(2)N(Ph)(2) is 1,3,5,7-tetraphenyl-1,5-diaza-3,7-diphosphacyclooctane, and P(Ph)(2)C(5) is 1,4-diphenyl-1,4-diphosphacycloheptane) have been synthesized and characterized by NMR spectroscopy, electrochemical studies, and X-ray diffraction. These chloride derivatives are readily converted to the corresponding hydride complexes [CpFe(P(Ph)(2)N(Bn)(2))H (1-H), CpFe(P(Ph)(2)N(Ph)(2))H (2-H), CpFe(P(Ph)(2)C(5))H (3-H)] and H(2) complexes [CpFe(P(Ph)(2)N(Bn)(2))(H(2))]BAr(F)(4), [1-H(2)]BAr(F)(4), (where BAr(F)(4) is B[(3,5-(CF(3))(2)C(6)H(3))(4)](-)), [CpFe(P(Ph)(2)N(Ph)(2))(H(2))]BAr(F)(4), [2-H(2)]BAr(F)(4), and [CpFe(P(Ph)(2)C(5))(H(2))]BAr(F)(4), [3-H(2)]BAr(F)(4), as well as [CpFe(P(Ph)(2)N(Bn)(2))(CO)]BAr(F)(4), [1-CO]Cl. Structural studies are reported for [1-H(2)]BAr(F)(4), 1-H, 2-H, and [1-CO]Cl. The conformations adopted by the chelate rings of the P(Ph)(2)N(Bn)(2) ligand in the different complexes are determined by attractive or repulsive interactions between the sixth ligand of these pseudo-octahedral complexes and the pendant N atom of the ring adjacent to the sixth ligand. An example of an attractive interaction is the observation that the distance between the N atom of the pendant amine and the C atom of the coordinated CO ligand for [1-CO]BAr(F)(4) is 2.848 Å, considerably shorter than the sum of the van der Waals radii of N and C atoms. Studies of H/D exchange by the complexes [1-H(2)](+), [2-H(2)](+), and [3-H(2)](+) carried out using H(2) and D(2) indicate that the relatively rapid H/D exchange observed for [1-H(2)](+) and [2-H(2)](+) compared to [3-H(2)](+) is consistent with intramolecular heterolytic cleavage of H(2) mediated by the pendant amine. Computational studies indicate a low barrier for heterolytic cleavage of H(2). These mononuclear Fe(II) dihydrogen complexes containing pendant amines in the ligands mimic crucial features of the distal Fe site of the active site of the [FeFe]-hydrogenase required for H-H bond formation and cleavage.
Influence of pore structure and chemical properties of supported molybdenum catalysts on their performance in upgrading heavy coal liquids (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInfluence of pore structure and chemical properties of supported molybdenum catalysts on their performance in upgrading heavy coal liquidsChunshan Song, Kouji Hanaoka, and Masakatsu NomuraCite this: Energy Fuels 1992, 6, 5, 619–628Publication Date (Print):September 1, 1992Publication History Published online1 May 2002Published inissue 1 September 1992https://pubs.acs.org/doi/10.1021/ef00035a013https://doi.org/10.1021/ef00035a013research-articleACS PublicationsRequest reuse permissionsArticle Views214Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Carbon nanotube electron emitters with a gated structure using backside exposure processes (2002)

We have fabricated fully vacuum-sealed 5 in. diagonal carbon nanotube field-emission displays of a gated structure with reliable electron emission characteristics. Single-walled carbon nanotube tips were implemented into the gate structure using self-aligned backside exposure of photosensitive carbon nanotube paste. An onset gate electrode voltage for emission was about 60 V and the luminance as high as 510 cd/m2 was exhibited under an application of 100 V and 1.5 kV to gate electrode and anode, respectively.
Optimal Calcium Intake (1994)

IT HAS BEEN a decade since the 1984 Consensus Development Conference on Osteoporosis first suggested that increased intake of calcium might help prevent osteoporosis. Osteoporosis affects more than 25 million people in the United States and is the major underlying cause of bone fractures in postmenopausal women and the elderly. Previous surveys have revealed that the US population experiences more than 1.5 million fractures annually at a cost in excess of $10 billion per year to the health care system. Two important factors that influence the occurrence of osteoporosis are optimal peak bone mass attained in the first two to three decades of life and the rate at which bone is lost in later years. Adequate calcium intake is critical to achieving optimal peak bone mass and modifies the rate of bone loss associated with aging. A number of publications have addressed the possible role of calcium intake in the
Side Population is Not Necessary or Sufficient for a Cancer Stem Cell Phenotype in Glioblastoma Multiforme (2010)

There is strong evidence for the existence of cancer stem cells (CSCs) in the aggressive brain tumor glioblastoma multiforme (GBM). These cells have stem-like self-renewal activity and increased tumor initiation capacity and are believed to be responsible for recurrence due to their resistance to therapy. Several techniques have been used to enrich for CSC, including growth in serum-free defined media to induce sphere formation, and isolation of a stem-like cell using exclusion of the fluorescent dye Hoechst 33342, the side population (SP). We show that sphere formation in GBM cell lines and primary GBM cells enriches for a CSC-like phenotype of increased self-renewal gene expression in vitro and increased tumor initiation in vivo. However, the SP was absent from all sphere cultures. Direct isolation of the SP from the GBM lines did not enrich for stem-like activity in vitro, and tumor-initiating activity was lower in sorted SP compared with non-SP and parental cells. Transient exposure to doxorubicin enhanced both CSC and SP frequency. However, doxorubicin treatment altered the cytometric profile and obscured the SP demonstrating the difficulty of identifying SP in cells under stress. Doxorubicin-exposed cells showed a transient increase in SP, but the doxorubicin-SP cells were still not enriched for a stem-like self-renewal phenotype. These data demonstrate that the GBM SP does not necessarily contribute to self-renewal or tumor initiation, key properties of a CSC, and we advise against using SP to enumerate or isolate CSC.
Order of magnitude improvement in thermal stability with use of liquid shower on a general purpose measuring machine (1982)

Over the past 25 years, LLNL has been developing and contributing to the technology of precision machining and diamond-turning. Advancement of the accuracy of machine tools has made it necessary to upgrade inspection tools as well. This paper describes the upgrading of a Moore Special Tool Co., No. 3 Measuring Machine. The results show that the liquid shower approach can be engineered to provide a simple and practical system having a dramatic improvement in thermal stability.
Development of a new activity-input-type ambulatory electrocardiogram and its clinical usefulness. (1991)

There are some problems with interpretation of the results of ambulatory electrocardiographic monitoring of patients with angina pectoris. To eliminate some of these difficulties, we developed a new activity-input-type ambulatory electrocardiogram which could simultaneously record the electrocardiogram and the patient's activities. Daily activities were classified into 8 levels from lying down to running or climbing a slope, in order to record them as analyzable square waves. Accuracy of the activity input to this equipment in 10 patients with effort angina was good, with 86.7% accuracy for eating and 91.7% for defecation. A comparison was made between the first and second recordings of daily activity changes in each exertional level. The numbers, mean duration and maximum duration of actions in each level were not always equal, and often changed between the two recordings. Maximum ST depression in each exertional level showed a favorable correlation of r = 0.931 (by 1.76 +/- 0.59 vs 1.77 +/- 0.66) between the first and the second recordings. The descriptions of activities recorded in patients diaries are unreliable indicators of time, because subjects check the time sometimes during, and sometimes after, the actions concerned. This equipment can easily make real-time recordings of such information, and thus provide advantages in research. When observing the pathologic condition of patients with angina pectoris and evaluating anti-anginal drug efficacy, information on the activity of each patient is important. This equipment therefore contributes to improving problems of ambulatory electrocardiographic monitoring for the patients with angina pectoris.