gebhart/patrepeval huggingface dataset:
Gene profiling of CD11b+ and CD11b− B1 cell subsets reveals potential cell sorting artifacts (2012)

In a recent issue of The Journal of Experimental Medicine, Griffin and Rothstein described two subsets within the human B1 cell compartment: a major CD11b  subset (9/10th of the population) and a minor CD11b + subset (1/10th of the population), with the latter being increased in lupus (Griffin and Rothstein, 2011).Griffin and Rothstein (2011) analyzed these two B1 cell subsets using gene profiling and compared these gene profiles with those of naive and memory blood B cells.A heat map is shown in Fig. 2 of their paper.This figure highlights a distinct expression profile for each of the CD11b + and CD11b  subsets compared with naive and memory B cells.Using the data deposited in the National Center for Biotechnology Information GEO database (GSE29717), we performed the same comparison and found that the gene profile of each of these subsets argues in favor of a different conclusion.For CD11b  B1 cells, the 50 most discriminating genes (comparing this subset to CD11b + B1 cells, naive cells, and memory B cells) include those encoding CD8; CD3; CD3; CD2; CD5; CD7; CD96; LAT; MAL; granzymes A, B, H, and K; and granulolysin (Fig. 1 A).This profile resembles that of cytotoxic CD8 + T cells.This subset also expresses CD19, CD22, and other B cell markers, which does not discriminate them from naive and memory B cells.Thus CD11b  B1 cells most likely consist of CD8 + T cell-B cell doublets.For CD11b + B1 cells, overexpressed genes include those encoding SIRP, CD33, CD68, CD163, CD302, IL-1, APRIL (TNFSF13), and CD14 (Fig. 1 B).These genes correspond to a myeloid profile.Underexpressed genes include those encoding CD79A and CD79B, and other B cell markers, including TACI,
A Service Oriented Information System: A Model Driven Approach (2012)

Generally the information system development is designing the systems with the use of visual design tools and takes the target modelling artefact as a basis to manually define the software application code. The process of mapping business requirements to the application code involves several parts that make the whole development process again very sensitive to errors. In this paper, we present a model-driven approach to overcome the gap between business requirements on one hand and service oriented architecture on the other. For this, we focus on the development of service oriented information system (SOIS) and a set of model transformation rules. Different ways of transforming a model into another exist. The choice of a target model differs according to quality criteria and is determined on the basis of specific requirements. The development process proposed is based on a BPMN meta-model, SOAML meta-model and a component meta-model. The approach leading elements are: the meta-modelling and automated mapping rules. Finally, we illustrate our proposal with a case study.
Beta 1 and beta 3 integrin upregulation in rapidly progressive glomerulonephritis. (1995)

The expression and distribution pattern of beta 1 (alpha 1-alpha 6) and alpha v beta 3 integrins and ICAM-1 and VCAM-1 counter receptors were evaluated by an immunohistochemical technique on eight renal samples from patients affected by rapidly progressive glomerulonephritis (RPGN) of different aetiologies. In all cases integrins and counterreceptors displayed similar patterns. On tubular cells of renal cortex, a marked upregulation of alpha 2 beta 1, alpha 3 beta 1, alpha 5 beta 1, alpha v beta 3 integrins and VCAM-1 was observed with as many as 60-90% of tubular cross-sections labelled, while a strong ICAM-1 reactivity was limited to the luminal surface. The same adhesion molecules were also uniformly expressed on crescentic cells. In glomeruli, integrin upregulation occurred only on apparently preserved capillary tufts, i.e. in an early stage of lesion, while collapsed and sclerotic tufts showed a reduced integrin expression. In addition a morphometric study of extracellular matrix (EM) proteins cellular fibronectin and tenascin showed a 9.56 +/- 1.9-fold and 3.35 +/- 0.6-fold increase respectively in these proteins, as compared to normal kidney (P < 0.001). The upregulation of alpha v beta 3 on podocytes might play a role in the adhesion of crescentic cells. An increased production of cytokines, in particular transforming growth factor-beta, might induce augmented deposition of EM proteins and upregulation of beta 1 and beta 3 integrins in RPGN.
Effects of atrial fibrillation on prognosis of acute myocardial infarction. (1978)

Nine hundred and sixty-nine coronary care patients with acute myocardial infarction were followed for one year. Atrial fibrillation was documented in 107 patients. Compared with patients without atrial fibrillation, those with this arrhythmia were older, had clinically more severe infarction, and had a higher frequency of ventricular fibrillation or tachycardia, and right bundle-branch block. They had similar past histories of ischaemic heart disease and coronary risk factors. Patients with atrial fibrillation had a higher total mortality at 3 months and 12 months. The presence of atrial fibrillation was not associated with any significant increase in mortality within any decade of age or within any subgroup of clinical severity of infarction. The frequency of atrial fibrillation was similar in anterior and inferior infarction. Multiple episodes of atrial fibrillation occurred in 52 patients and episodes usually lasted for over 1 hour. In 50% of patients with single episode of atrial fibrillation the initial ventricular rate was greater than 120 beats per minute.
Organoboron Compounds. X.<sup>1,2</sup> Popcorn Polymers and Highly Cross-linked Vinyl Polymers Containing Boron (1959)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOrganoboron Compounds. X.1,2 Popcorn Polymers and Highly Cross-linked Vinyl Polymers Containing BoronRobert L. Letsinger and Stephen B. HamiltonCite this: J. Am. Chem. Soc. 1959, 81, 12, 3009–3012Publication Date (Print):June 1, 1959Publication History Published online1 May 2002Published inissue 1 June 1959https://doi.org/10.1021/ja01521a023RIGHTS & PERMISSIONSArticle Views341Altmetric-Citations40LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (528 KB) Get e-Alerts Get e-Alerts
Artificial gauge field for photons in coupled cavity arrays (2011)

We propose and characterize solid-state photonic structures where light experiences an artificial gauge field. A nontrivial phase for photons tunneling between adjacent sites of a coupled cavity array can be obtained by inserting optically active materials in the structure or by inducing a suitable coupling of the propagation and polarization degrees of freedom. We also discuss the feasibility of observing strong gauge field effects in the optical spectra of realistic systems, including the Hofstadter butterfly spectrum.
Nasal Carriage of Methicillin-Resistant Staphylococcus aureus among Pediatricians in Taiwan (2013)

Around seven percent of pediatricians in Taiwan harbored CA-MRSA in their nares.
Wind speed prediction based on simple meteorological data using artificial neural network (2009)

Air temperature, relative humidity and vapor pressure data during 1993-2004 for city of Manjil in Iran were used for the estimation of wind speed in future time domain using artificial neural network method. The estimations of wind speed were made using three combinations of data sets namely: (i) month of the year, monthly mean daily air temperature and relative humidity as inputs and wind speed as output, (ii) month of the year, monthly mean daily air temperature, relative humidity and vapor pressure as inputs and wind speed as output and (iii) month of the year, monthly maximum daily air temperature, relative humidity and vapor pressure as inputs and wind speed as output . The measured data between 1993 and 2003 were used for training the multilayer perceptron (MLP) neural networks and the 12 months. data from 2004 as testing data. The testing data were not used for training the neural networks. The mean squared errors (MSE) for (i), (ii) and (iii) were found to be 0.003297, 0.003416 and 0.00208655 while the mean absolute percentage errors (MAPE) for testing data were 10.32%, 7.03% and 10.78%.Obtained Results show that neural networks are well capable of estimating wind speed from temperature, relative humidity and vapor pressure.
Virtual interval caching scheme for interactive multimedia streaming workload (2003)

We carefully believe that server workload for interactive multimedia service exhibits different characteristics from legacy application, e.g. ftp server, web server, ASP server and etc., and that there are greater chance of improvement with better understanding of streaming workload. In this work, we present a novel buffer management algorithm for interactive multimedia streaming workload. We carefully examine the workload traces obtained from several streaming servers in service. The analysis results show that most users exhibit non-sequential access pattern using VCR-like operations such as jump backward and jump forward. We exploit the workload characteristics of the VCR-like operation and develop a buffer caching algorithm called Virtual Interval Caching scheme. Simulation based experiment shows that the proposed buffer management scheme yields better performance than the legacy schemes.
Splintig with a New Thermoplastic Material (1967)

OF PARIS splints for the hand, wrist, and fingers have been used successfully in our clinic for more than 550 patients. The relatively short life of plaster splints often offsets their advantages, however, especially if the patient is discharged and is unable to return for a replacement when neces sary.
Caging the uncageable: using metal complex release for photochemical control over irreversible inhibition (2016)

Photochemical control over irreversible inhibition was shown using Ru(ii)-caged inhibitors of cathepsin L. Levels of control were dependent on where the Ru(ii) complex was attached to the organic inhibitor, reaching >10 : 1 with optimal placement. A new strategy for photoreleasing Ru(ii) fragments from inhibitor-enzyme conjugates is also reported.
SNPSelect: A scalable and flexible targeted sequence-based genotyping solution (2018)

In plant breeding the use of molecular markers has resulted in tremendous improvement of the speed with which new crop varieties are introduced into the market. Single Nucleotide Polymorphism (SNP) genotyping is routinely used for association studies, Linkage Disequilibrium (LD) and Quantitative Trait Locus (QTL) mapping studies, marker-assisted backcrosses and validation of large numbers of novel SNPs. Here we present the KeyGene SNPSelect technology, a scalable and flexible multiplexed, targeted sequence-based, genotyping solution. The multiplex composition of SNPSelect assays can be easily changed between experiments by adding or removing loci, demonstrating their content flexibility. To demonstrate this versatility, we first designed a 1,056-plex maize assay and genotyped a total of 374 samples originating from an F2 and a Recombinant Inbred Line (RIL) population and a maize germplasm collection. Next, subsets of the most informative SNP loci were assembled in 384-plex and 768-plex assays for further genotyping. Indeed, selection of the most informative SNPs allows cost-efficient yet highly informative genotyping in a custom-made fashion, with average call rates between 88.1% (1,056-plex assay) and 99.4% (384-plex assay), and average reproducibility rates between duplicate samples ranging from 98.2% (1056-plex assay) to 99.9% (384-plex assay). The SNPSelect workflow can be completed from a DNA sample to a genotype dataset in less than three days. We propose SNPSelect as an attractive and competitive genotyping solution to meet the targeted genotyping needs in fields such as plant breeding.
Analysis of the wideband external pulse: An application of graphical methods (1994)

This paper demonstrates the power of statistical graphics in gleaning information from very large medical data sets. In the case of the particular data set described here (the wideband external pulse signal) little was known about the shape of the signal and the relationship of that shape to the characteristics of the related physical system, the cardiovascular system. Previous numerical statistical analyses of the data were unfruitful in finding the important relationships which were easily discovered through the appropriately designed graphics. The paper also describes the process of designing graphics to help in discovering the important relationships in the data.
Isatins As Privileged Molecules in Design and Synthesis of Spiro-Fused Cyclic Frameworks (2012)

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTIsatins As Privileged Molecules in Design and Synthesis of Spiro-Fused Cyclic FrameworksGirija S. Singh*† and Zelalem Y. Desta†View Author Information† Chemistry Department, University of Botswana, Private Bag: 0022, Gaborone, Botswana*E-mail: [email protected]Cite this: Chem. Rev. 2012, 112, 11, 6104–6155Publication Date (Web):September 6, 2012Publication History Received30 March 2012Published online6 September 2012Published inissue 14 November 2012https://pubs.acs.org/doi/10.1021/cr300135yhttps://doi.org/10.1021/cr300135yreview-articleACS PublicationsCopyright © 2012 American Chemical SocietyRequest reuse permissionsArticle Views18671Altmetric-Citations1372LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Addition reactions,Catalysts,Chemical reactions,Cyclization,Stereoselectivity Get e-Alerts
The Replacement of Phenolic Hydroxyl Groups by Hydrogen (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Replacement of Phenolic Hydroxyl Groups by HydrogenWalter J. Musliner and John W. Gates Jr.Cite this: J. Am. Chem. Soc. 1966, 88, 18, 4271–4273Publication Date (Print):September 1, 1966Publication History Published online1 May 2002Published inissue 1 September 1966https://pubs.acs.org/doi/10.1021/ja00970a037https://doi.org/10.1021/ja00970a037research-articleACS PublicationsRequest reuse permissionsArticle Views434Altmetric-Citations93LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Diversity at the variable-joining region boundary of lambda light chains has a pronounced effect on immunoglobulin ligand-binding activity. (1984)

By recombining lambda light (L) chains having known variable (V) region amino acid or nucleotide sequences with a heavy (H) chain from a myeloma protein or a monoclonal antibody, we obtained reconstituted Igs that differed from each other in sequence by only one or a few amino acid substitutions at known L chain positions. Differences in affinity of the reconstituted Igs for 2,4-dinitrophenyl (DNP) ligands revealed a pronounced effect on Ig binding activity of amino acids at the V-J boundary of the lambda chains. In one instance, two reconstituted Igs that differed about 1000-fold in affinity for epsilon-DNP-aminocaproate differed in primary structure by only a single tyrosine-phenylalanine substitution at the V-J junction (position 98) of their lambda 2 chains--i.e., by only one out of approximately 660 amino acid residues (L + H chains). By focusing on affinity changes, chains with unusual V lambda-J lambda junctional residues were identified. It is possible that because of a critical effect on tertiary structure junctional amino acid variations arising from gene segment assembly (V/J and perhaps V/D/J) constitute an important source of ligand-binding diversity of antibodies.
Expression and the functional role of a p70/75 interleukin 2-binding molecule in human B cell. (1988)

Expression of p70/75 IL-2-binding molecules and their functional roles in induction of Ig secretion by IL-2 were examined in human B cells. IL-2, at high concentrations induced higher levels of Ig secretion in Staphylococcus aureus strain Cowan I (SAC)-activated B cells than at low concentrations. About 50% of SAC-activated B cells, lacking Tac antigen, were also responsive to Ig secretion by IL-2, although the required dose of IL-2 was higher than that for Tac-positive B cells. H-31 antibody which recognizes Tac antigen did not inhibit the induction of Ig secretion by high concentrations of IL-2 in both Tac-negative and Tac-positive B cells, suggesting that IL-2 might induce Ig secretion through a receptor distinct from Tac antigens. In contrast, IL-2 was ineffective in the absence of SAC stimulation even at high concentrations. Upon analysis by SDS-PAGE, p70/75 IL-2-binding molecules were detected on Tac-negative SAC-activated B cells. Similar IL-2-binding molecules distinct from Tac antigen (p55) were detected in both Tac-positive B and T cells. However, neither p55 nor p70/75 IL-2-binding molecules could be detected in the absence of SAC stimulation. These observations suggest that p70/75 IL-2 binding molecules are induced in human B-cells in the presence or absence of Tac antigen by SAC stimulation and these determinants play an important function in the transduction of IL-2 associated signal for B cell differentiation.
Magnetic Resonance Imaging Advances in Multiple Sclerosis (2005)

Magnetic resonance imaging (MRI) has become a core component of clinical management and scientific research in multiple sclerosis (MS), providing essential information about tissue structure and function. MRI is now the most important laboratory diagnostic and longitudinal monitoring technology. A number of conventional MRI techniques, which include T2-weighted, T1-weighted, and gadolinium-enhanced imaging, are used to identify overt lesions and quantify tissue atrophy. MRI is highly sensitive in detecting brain and spinal cord involvement in MS and can visualize multifocal lesions, occult disease, and macroscopic atrophy. Advanced MRI techniques, such as magnetization transfer imaging, spectroscopy, diffusion-weighted imaging, and functional MRI, have added to our understanding of the pathogenesis of the disease. The precise role of these newer imaging approaches continues to be defined. In this supplement to the Journal of Neuroimaging, the authors review the role of conventional and advanced MRI techniques in detecting tissue changes in MS, diagnosing and monitoring patients, and charting the progression of disease in new and established patients.
Pattern of olfactory bulb innervation returns after recovery from reversible peripheral deafferentation (2000)

The olfactory epithelium (OE) is unusual in its ability to regenerate and reinnervate its target, the olfactory bulb (OB), after deafferentation. To address the question of whether olfactory receptor neuron (ORN) axons preserve their topographic organization when they reestablish synaptic contact with the OB, the authors examined the pattern of ORN axon reinnervation into the bulb of adult H-OMP-lacZ-6 transgenic mice during and after recovery from chemical deafferentation. In the H-OMP-lacZ-6 mouse strain, lacZ expression is limited to a subset of ORNs that are distributed bilaterally in the OE and project primarily to a few glomeruli in the ventromedial region of the OB. The OE was lesioned by intranasal irrigation with Triton X-100, and the distribution of 5-bromo-4-chloro-3-indolyl-beta-D-galactopyranoside (X-gal)-stained cells was examined in the OE along with beta-galactosidase-immunoreactive (beta-gal-ir) axonal processes in the OB after short (1 week), intermediate (3 week), and long (6-7 weeks) recovery times. One week after the lesion, immunostaining for beta-gal and olfactory marker protein was virtually eliminated in the bulb. After 3 weeks of recovery, beta-gal-containing axons appeared to target many of the same locations innervated in bulbs of unlesioned mice. The region that received the highest density of axonal innervation in controls, however, contained only a few processes at that time. After 6-7 week recovery periods, the pattern of X-gal staining in the OE and beta-gal-ir axons in the OB closely resembled that of unlesioned mice. These results demonstrate that the topographic distribution of ORNs in the OE and the pattern of axon innervation in the OB can be reconstituted after chemical deafferentation.
Looking back, looking forward (2019)

Professor Plantinga Pauw was invited to give a perspective on the Presbyterian Church of the United States of America’s adoption of a book of confessions rather than a single confessional standard. Her paper speaks of her experience of using the PC(USA)’s Book of Confessions both as a member of the church and as a teacher of doctrinal theology in a Presbyterian seminary. It describes the church’s current Book of Confessions, examines the reasons for its adoption, and provides examples of the benefits she believes it has provided to the church.