gebhart/patrepeval huggingface dataset:
Pharmacodynamic and -kinetic Behavior of Low-, Intermediate-, and High-Dose Landiolol During Long-Term Infusion in Whites (2017)

Pharmacokinetics, pharmacodynamics, safety, and tolerability of long-term administration of landiolol, a fast-acting cardioselective β-blocker, were investigated for the first time in white subjects in a prospective clinical trial. Blood concentrations of landiolol and its metabolites, heart rate (HR), blood pressure (BP), and electrocardiogram parameters were studied in 12 healthy volunteers receiving continuous infusions of a new 12-mg/mL formulation of landiolol using a dose-escalation regimen (10 μg/kg BW/min for 2 hours, 20 μg/kg BW/min for 2 hours, 40 μg/kg BW/min for 20 hours, 6 hours follow-up). Landiolol blood concentrations were dose proportional. Time until steady state decreased with increasing doses. Pharmacokinetic parameters were t1/2 = 4.5 minutes, VD = 366 mL/kg, and total body clearance = 53 mL·kg·min. Maximal blood concentrations of the inactive main metabolite M1 were 10-fold higher than those of landiolol, with t1/2 = 126 minutes, VD = 811 mL/kg, and total body clearance = 4.5 mL·kg·min. HR reduction from baseline was fast (significant after 16 minutes) and sustained throughout the administration period. Systolic and diastolic BP reductions and electrocardiogram parameter changes were less pronounced and became significant only occasionally. Recovery after discontinuation of infusion was fast with little (HR) or no (BP) rebound. The new formulation showed excellent local and general tolerability.
Method and apparatus for the production of electret material (1986)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Jeff L. Anderson; Method and apparatus for the production of electret material. J. Acoust. Soc. Am. 1 May 1986; 79 (5): 1647. https://doi.org/10.1121/1.393218 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAcoustical Society of AmericaThe Journal of the Acoustical Society of America Search Advanced Search |Citation Search
Comparison Between Pi And Pr Current Controllers In Grid Connected Pv Inverters (2014)

This paper presents a comparison between Proportional Integral (PI) and Proportional Resonant (PR) current controllers used in Grid Connected Photovoltaic (PV) Inverters. Both simulation and experimental results will be presented. A 3kW Grid-Connected PV Inverter was designed and constructed for this research.
Divergent β-Arrestin-dependent Signaling Events Are Dependent upon Sequences within G-protein-coupled Receptor C Termini (2012)

β-Arrestins are multifunctional adaptor proteins that, upon recruitment to an activated G-protein-coupled receptor, can promote desensitization of G-protein signaling and receptor internalization while simultaneously eliciting an independent signal. The result of β-arrestin signaling depends upon the activating receptor. For example, activation of two Gα(q)-coupled receptors, protease-activated receptor-2 (PAR(2)) and neurokinin-1 receptor (NK1R), results in drastically different signaling events. PAR(2) promotes β-arrestin-dependent membrane-sequestered extracellular signal-regulated kinase (ERK1/2) activation, cofilin activation, and cell migration, whereas NK1R promotes nuclear ERK1/2 activation and proliferation. Using bioluminescence resonance energy transfer to monitor receptor/β-arrestin interactions in real time, we observe that PAR(2) has a higher apparent affinity for both β-arrestins than does NK1R, recruits them at a faster rate, and exhibits more rapid desensitization of the G-protein signal. Furthermore, recruitment of β-arrestins to PAR(2) does not require prior Gα(q) signaling events, whereas inhibition of Gα(q) signaling intermediates inhibits recruitment of β-arrestins to NK1R. Using chimeric receptors in which the C terminus of PAR(2) is fused to the N terminus of NK1R and vice versa and a critical Ser/Thr mutant of PAR(2), we demonstrate that interactions between β-arrestins and specific phosphoresidues in the C termini of each receptor are crucial for determining the rate and magnitude of β-arrestin recruitment as well as the ultimate signaling outcome.
Mechanisms of Isoimmunization (1967)

Abstract 1. Fetal cells were demonstrated postpartum in approximately 20 per cent of Rh positive mothers with ABO incompatible infants and in only approximately 5 per cent of Rh negative mothers with both ABO and Rh incompatible infants in the absence of sensitization or presensitization. 2. When the prenatal findings were combined with those postpartum, the incidence was considerably greater in both groups (52 per cent and 32 per cent, respectively). 3. Two cases of massive transplacental hemorrhage in heterospecific pregnancies are reported with almost a normal survival of a few cells postpartum. 4. Observations on protective mechanisms bearing on isoimmunization in heterospecific pregnancies are made.
Effects of Peritoneal Rest on Peritoneal Transport and Peritoneal Membrane Thickening in Continuous Ambulatory Peritoneal Dialysis Rats (1999)

Peritoneal rest improves ultrafiltration in rats by decreasing the hyperpermeability of glucose and also reduces the degree of peritoneal thickening. These data suggest that dialysis-induced changes in peritoneal transport and morphology are reversible under the conditions of peritoneal rest in this experimental model.
Serial increase in the thermal stability of 3‐isopropylmalate dehydrogenase from Bacillus subtilis by experimental evolution (1998)

We improved the thermal stability of 3-isopropylmalate dehydrogenase from Bacillus subtilis by an in vivo evolutionary technique using an extreme thermophile, Thermus thermophilus, as a host cell. The leuB gene encoding B. subtilis 3-isopropylmalate dehydrogenase was integrated into the chromosome of a leuB-deficient strain of T. thermophilus. The resulting transformant showed a leucine-autotrophy at 56 degrees C but not at 61 degrees C and above. Phenotypically thermostabilized strains that can grow at 61 degrees C without leucine were isolated from spontaneous mutants. Screening temperature was stepwise increased from 61 to 66 and then to 70 degrees C and mutants that showed a leucine-autotrophic growth at 70 degrees C were obtained. DNA sequence analyses of the leuB genes from the mutant strains revealed three stepwise amino acid replacements, threonine-308 to isoleucine, isoleucine-95 to leucine, and methionine-292 to isoleucine. The mutant enzymes with these amino acid replacements were more stable against heat treatment than the wild-type enzyme. Furthermore, the triple-mutant enzyme showed significantly higher specific activity than that of the wild-type enzyme.
High power and good beam quality at 980 nm from a vertical external-cavity surface-emitting laser (2002)

We demonstrate 1.5-W continuous-wave output power from a vertical external-cavity surface-emitting laser (VECSEL) based on InGaAs quantum wells as the gain medium. The VECSEL is pumped by the output of a single-bar diode-laser array at 814 nm and produces an optical-to-optical efficiency of 19%. The high output power is made possible by the use of a sapphire window optically contacted to the intracavity semiconductor surface for heat removal. We demonstrate the good beam quality of the VECSEL output by obtaining 1-W output from a single-mode fiber for 1.5 W launched with simple lenses. Pulsed operation produces a maximum peak power of ∼4.4 W and maximum average power of ∼2 W.
World Wide Web Technology in Support of Negotiation and Communication (1998)

With the advent of the mass use of the Internet involving the classic use of e-mail, file transfer and now the more recent use of www applications, such as home pages, chat, Internet phone, audio and video and web broadcast systems, business transactions over the net are increasing dramatically. An important, yet relatively undeveloped component for electronic commerce is the negotiation of contracts and the resolution of disputes. We discuss Web-based technology and practice in supporting business negotiations and communication. The focus of the paper is on the present and the future promises of such technology.
Metallindikatoren VII. Die Aciditätskonstanten und der Eisenkomplex des N,N′‐Äthylen‐bis‐(o‐hydroxyphenyl‐glycins (EHPG)) (1964)

Abstract The acidity constants of N, N′‐Ethylene‐bis‐(o‐hydroxyphenyl‐glycine) (= EHPG)have been determined. The stability constant of the 1:1 complex with trivalent iron has been determined from optical measurements of the equilibrium with trimethylene‐diamine‐tetraacetic acid. Among the studied ligands EHPG forms the stablest 1:1 complex with iron(II1). This red complex can be used in acid solution as indicator for the complexometric titration of iron.
Linear integration of spine Ca <sup>2+</sup> signals in layer 4 cortical neurons in vivo (2014)

Sensory information reaches the cortex through synchronously active thalamic axons, which provide a strong drive to layer 4 (L4) cortical neurons. Because of technical limitations, the dendritic signaling processes underlying the rapid and efficient activation of L4 neurons in vivo remained unknown. Here we introduce an approach that allows the direct monitoring of single dendritic spine Ca(2+) signals in L4 spiny stellate cells of the vibrissal mouse cortex in vivo. Our results demonstrate that activation of N-methyl-D-aspartate (NMDA) receptors is required for sensory-evoked action potential (AP) generation in these neurons. By analyzing NMDA receptor-mediated Ca(2+) signaling, we identify whisker stimulation-evoked large responses in a subset of dendritic spines. These sensory-stimulation-activated spines, representing predominantly thalamo-cortical input sites, were denser at proximal dendritic regions. The amplitude of sensory-evoked spine Ca(2+) signals was independent of the activity of neighboring spines, without evidence for cooperativity. Furthermore, we found that spine Ca(2+) signals evoked by back-propagating APs sum linearly with sensory-evoked synaptic Ca(2+) signals. Thus, our results identify in sensory information-receiving L4 cortical neurons a linear mode of dendritic integration that underlies the rapid and reliable transfer of peripheral signals to the cortical network.
Thermotropic liquid crystalline main-chain polyesters containing cyclooctyl units. Part 4. Influence of the methylene spacer length on the nature of the mesophase (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThermotropic liquid crystalline main-chain polyesters containing cyclooctyl units. Part 4. Influence of the methylene spacer length on the nature of the mesophaseJ. M. G. Cowie and H. H. WuCite this: Macromolecules 1988, 21, 9, 2865–2869Publication Date (Print):September 1, 1988Publication History Published online1 May 2002Published inissue 1 September 1988https://pubs.acs.org/doi/10.1021/ma00187a036https://doi.org/10.1021/ma00187a036research-articleACS PublicationsRequest reuse permissionsArticle Views41Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Thrombolytic Therapy: Current Status (1988)

Therapeutic IssuesRegionalization of TherapyThe possibility of increasing thrombolysis without causing bleeding has motivated efforts to direct therapy selectively to the pathologic thrombus. Two approaches that have been tried are administration of agents that may bind selectively to a thrombus, and regional infusion of agents into the occluded vessel in order to restrict therapy anatomically to the thrombus. Both methods have theoretical advantages, but experience has revealed practical problems with each technique.The concept that the effects of thrombolytic therapy on the coagulation mechanism initiate bleeding provided the rationale for the use of fibrin-selective agents, each of which exploits . . .
Mixed-Initiative Control of a Roadable Air Vehicle for Non-Pilots (2015)

This work developed and evaluated a human-machine interface for the control of a roadable air vehicle (RAV), capable of surface driving, vertical takeoff, sustained flight, and landing. Military applications seek to combine the benefits of ground and air vehicles to maximize flexibility of movement but require that the operator have minimal pilot training. This makes the operator vulnerable to automation complexity issues; however, the operator will expect to be able to interact extensively and control the vehicle during flight. A mixed-initiative control approach mitigates these vulnerabilities by integrating the operator into many complex control domains in the way that they often expect---flexibly in charge, aware, but not required to issue every command. Intrinsic safety aspects were evaluated by comparing performance, decision making, precision, and workload for three RAV control paradigms: human-only, fully automated, and mixed-initiative control. The results suggest that the mixed-initiative paradigm leverages the benefits of human and automated control while also avoiding the drawbacks associated with each.
Role of TGF-β signaling in inherited and acquired myopathies (2011)

The transforming growth factor-beta (TGF-β) superfamily consists of a variety of cytokines expressed in many different cell types including skeletal muscle. Members of this superfamily that are of particular importance in skeletal muscle are TGF-β1, mitogen-activated protein kinases (MAPKs), and myostatin. These signaling molecules play important roles in skeletal muscle homeostasis and in a variety of inherited and acquired neuromuscular disorders. Expression of these molecules is linked to normal processes in skeletal muscle such as growth, differentiation, regeneration, and stress response. However, chronic elevation of TGF-β1, MAPKs, and myostatin is linked to various features of muscle pathology, including impaired regeneration and atrophy. In this review, we focus on the aberrant signaling of TGF-β in various disorders such as Marfan syndrome, muscular dystrophies, sarcopenia, and critical illness myopathy. We also discuss how the inhibition of several members of the TGF-β signaling pathway has been implicated in ameliorating disease phenotypes, opening up novel therapeutic avenues for a large group of neuromuscular disorders.
[Limb ischemic preconditioning reduces rabbit hepatic ischemia-reperfusion injury through inhibition the phosphorylation of proteins in the MAPK signal pathway in the late phase]. (2012)

Limb ischemia pre-treatment can induce the late phase of preconditioning in rabbit liver through the inhibition of the phosphorylation of P38MAPK and JNK.
Neurocosmetics in Skincare—The Fascinating World of Skin–Brain Connection: A Review to Explore Ingredients, Commercial Products for Skin Aging, and Cosmetic Regulation (2021)

The “modern” cosmetology industry is focusing on research devoted to discovering novel neurocosmetic functional ingredients that could improve the interactions between the skin and the nervous system. Many cosmetic companies have started to formulate neurocosmetic products that exhibit their activity on the cutaneous nervous system by affecting the skin’s neuromediators through different mechanisms of action. This review aims to clarify the definition of neurocosmetics, and to describe the features of some functional ingredients and products available on the market, with a look at the regulatory aspect. The attention is devoted to neurocosmetic ingredients for combating skin stress, explaining the stress pathways, which are also correlated with skin aging. “Neuro-relaxing” anti-aging ingredients derived from plant extracts and neurocosmetic strategies to combat inflammatory responses related to skin stress are presented. Afterwards, the molecular basis of sensitive skin and the suitable neurocosmetic ingredients to improve this problem are discussed. With the aim of presenting the major application of Botox-like ingredients as the first neurocosmetics on the market, skin aging is also introduced, and its theory is presented. To confirm the efficacy of the cosmetic products on the market, the concept of cosmetic claims is discussed.
Generalized Simulated Annealing for Function Optimization (1986)

Abstract A generalized simulated annealing method has been developed and applied to the optimization of functions (possibly constrained) having many local extrema. The method is illustrated in some difftcult pedagogical examples and used to solve a problem analyzed by Bates (Technometrics, 25, pp. 373–376, 1983) for which we identify an improved optimum. The sensitivity of the solution to changes in the constraints and in other specifications of the problem is analyzed and discussed. KEY WORDS: Sensitivity analysisOptimal designMultiple extremaBoltzmann's distributionBiased random walkMetropolis algorithm
Broadband Absorbing Exciton–Plasmon Metafluids with Narrow Transparency Windows (2016)

Optical metafluids that consist of colloidal solutions of plasmonic and/or excitonic nanomaterials may play important roles as functional working fluids or as means for producing solid metamaterial coatings. The concept of a metafluid employed here is based on the picture that a single ballistic photon, propagating through the metafluid, interacts with a large collection of specifically designed optically active nanocrystals. We demonstrate water-based metafluids that act as broadband electromagnetic absorbers in a spectral range of 200-3300 nm and feature a tunable narrow (∼100 nm) transparency window in the visible-to-near-infrared region. To define this transparency window, we employ plasmonic gold nanorods. We utilize excitonic boron-doped silicon nanocrystals as opaque optical absorbers ("optical wall") in the UV and blue-green range of the spectrum. Water itself acts as an opaque "wall" in the near-infrared to infrared. We explore the limits of the concept of a "simple" metafluid by computationally testing and validating the effective medium approach based on the Beer-Lambert law. According to our simulations and experiments, particle aggregation and the associated decay of the window effect are one example of the failure of the simple metafluid concept due to strong interparticle interactions.
Recruiting physisorbed water in surface polymerization for bio-inspired materials of tunable hydrophobicity (2016)

Chemical grafting has been widely used to modify the surface properties of materials, especially surface energy for controlled wetting, because of the resilience of such coatings/modifications.
Visible light photocatalysis with nitrogen-doped titanium dioxide nanoparticles prepared by plasma assisted chemical vapor deposition (2006)

Nitrogen-doped TiO2 nanoparticles were synthesized via plasma assisted metal organic chemical vapor deposition. Nitrogen dopant concentration was varied from 0to1.61at.%. The effect of nitrogen ion doping on visible light photocatalysis has been investigated. Samples were analyzed by various analytical techniques such as x-ray diffraction, transmission electron microscopy, x-ray photoelectron spectroscopy, and near-edge x-ray absorption fine structure. Titanium tetraisopropoxide was used as the titanium precursor, while rf-plasma-decomposed ammonia was used as the source for nitrogen doping. The N-doped TiO2 nanoparticles were deposited on stainless steel mesh under a flow of Ar and O2 gases at 600°C in a tube reactor. The photocatalytic activity of the prepared N-doped TiO2 samples was tested by the degradation of 2-chlorophenol (2-CP) in an aqueous solution using a visible lamp equipped with an UV filter. The efficiency of photocatalytic oxidation of 2-CP was measured using high performance liquid chromatography. Results obtained revealed the formation of N-doped TiO2 samples as TiO2−xNx, and a corresponding increase in the visible light photocatalytic activity.
Annotating knowledge work lifelog (2011)

We present a system that supports review of a knowledge work lifelog as an activity history. Since knowledge workers often review their own activity histories, gathering each user's activities on his/her terminal as a lifelog is a promising approach. However, readability of the stored lifelog is a large problem of lifelog-based application. We propose a term extraction method to add annotation labels to the stored lifelog for supporting knowledge workers, exploiting text data acquired from desktop activities. Our prototype system monitors a user's desktop activities after combining raw events, and then extracts possible annotation labels with LDA and C-value techniques from documents and text data in sensor events. In this paper, we introduce a lifelogging module and a lifelog annotation method based on term extraction techniques. According to an empirical evaluation for three weeks, we found that the current method is useful for one-week review.
Preclinical to Clinical Translation of CNS Transporter Occupancy of TD-9855, a Novel Norepinephrine and Serotonin Reuptake Inhibitor (2015)

These data establish the CNS penetration and transporter profile of TD-9855 and inform the selection of potential doses for future clinical evaluation.
Tuning the pH Response of i‐Motif DNA Oligonucleotides (2015)

Cytosine-rich single-stranded DNA oligonucleotides are able to adopt an i-motif conformation, a four-stranded structure, near a pH of 6. This unique pH-dependent conformational switch is reversible and hence can be controlled by changing the pH. Here, we show that the pH response range of the human telomeric i-motif can be shifted towards more basic pH values by introducing 5-methylcytidines (5-MeC) and towards more acidic pH values by introducing 5-bromocytidines (5-BrC). No thermal destabilisation was observed in these chemically modified i-motif sequences. The time required to attain the new conformation in response to sudden pH changes was slow for all investigated sequences but was found to be ten times faster in the 5-BrC derivative of the i-motif.
Bi-axial Gegenbauer functions of the first and second kind (1996)

The classical orthogonal polynomials defined on intervals of the real line are related to many important branches of analysis and applied mathematics. Here a method is described to generalise this concept to polynomials defined on higher dimensional space
Two-dimensional mechanical and ultrastructural correlates of bovine pericardium for prosthetic valves. (1992)

Scanning electron microscopy of bovine pericardium (BP) shows anisotropic collagen fiber orientation (CFO). We studied the effect of CFO on the breaking strength of longitudinal (L) and transverse (T) strips cut from six pieces of fresh (Fr), glutaraldehyde (Glu)-, or formaldehyde (For)-fixed BP loaded at constant rate until rupture. Maximum tensile stress (Stmax) and strain (Snmax) were measured. The Stmax of L strips were larger than T ones in all groups, and Snmax was the same. Similar results were also observed in 10 pieces of Glu fixed normal canine mitral valves (MV). Maximum tensile stress is obtained when the load is parallel to CFO in both canine MV and BP.