gebhart/patrepeval huggingface dataset:
Reversible Binding of NO to Fe(II)edta (1979)

Abstract The equilibrium constants, enthalpy, and entropy of the reversible binding of nitrogen oxide to Fe(II)edta in an aqueous solution have been measured in the temperature range 38.5 to 70 °C. Experiments were carried out by absorbing NO under O2 free conditions. The results show that, in the absorption of NO with Fe(II)edta solution, the value of ΔH° is −15.8 kcal/mol and ΔS° is −20.7 e.u.
Identification of a<i>mariner</i>-like repetitive sequence in<i>C.elegans</i> (1994)

A repetitive element in C.elegans has been found that bears high homology to the element mariner of Drosophila mauritiana (EMBL accession number X77804). This element is present in about 20 copies in the N2 strain of C.elegans, and appears in roughly equal copy numbers in the related strain BO and in the hybrid strains RW7097 and TR679. There is only one copy of this MLE in three related species of Caenorhabditis. A cDNA of this mariner-like element (MLE) codes for a protein with 58% homology to the Drosophila transposase. The mariner-like element is not mobile in N2. This class of elements has now been described in insects, planaria and nematodes (GenBank accession number M98552 and this report).
Finite element modelling of cornea mechanics: a review (2014)

The cornea is a transparent tissue in front of the eye that refracts light and facilitates vision. A slight change in the geometry of the cornea remarkably affects the optical power. Because of this sensitivity, biomechanical study of the cornea can reveal much about its performance and function. In vivo and in vitro studies have been conducted to investigate the mechanics of the cornea and determine its characteristics. Numerical techniques such as the finite element method (FEM) have been extensively implemented as effective and noninvasive methods for analyzing corneal mechanics and possible disorders. This article reviews the use of FEM for assessing the mechanical behavior of the cornea. Different applications of FEM in corneal disease studies, surgical predictions, impact simulations, and clinical applications have been reviewed. Some suggestions for the future of this type of modeling in the area of corneal mechanics are also discussed.
Prostate Cancer Susceptibility Polymorphism rs2660753 Is Not Associated with Invasive Ovarian Cancer (2011)

Our findings, based on a larger sample size, emphasize the importance of replicating potentially promising genetic risk associations.
Analytical Method for Sugar Chain Structures Involving Lectins and Membrane Ultrafiltration (1993)

A simple and rapid analytical method for the structural identification of sugar chains involving lectins and ultrafiltration was developed. In the procedure, a mixture of fluorogenic sugar chains is mixed with an unmodified lectin. Unbound sugar chains are removed by ultrafiltration. Qualitative differences between sugar chains from the sample and from the filtrate were determined by high performance liquid chromatography. The structures of different sugar chains could be determined from the specificity of the lectins used. Because the lectins used for the procedure were not modified, both the lectins used and sugar chains could be recovered. The method is simple and can be used for structural analysis of sugar chains.
Matched Image Formation/Digital Processing Systems. (1997)

Abstract : Three design tools for hybrid optical/digital imaging systems have been developed that provide new ways of designing the non-conventional imaging systems that are optimum for extended depth of field/focus, and for passively determining the range to objects in a scene. The first tool developed was a defocus transfer function (DTF) for imaging systems with radially symmetric pupils. The DTF allows one to visualize how the modulation transfer function (MTF) will change with focus. Prior work was valid only for one-dimensional optical systems. The second tool uses a form of a Radon-Wigner distribution to show the impulse response, or point spread function, as the focus changes. The third tool is the use of linear transformation operators to analyze and simulate optical systems. These three tools are proving to be very' powerful in the design of hybrid optical/signal processing systems.
Chemoradiotherapy with or without consolidation chemotherapy using cisplatin and 5-fluorouracil in anal squamous cell carcinoma: long-term results in 31 patients (2008)

our study shows that CRT with 5-FU and cisplatin, with or without consolidation chemotherapy, was well tolerated and proved highly encouraging in terms of long-term survival and the preservation of anal function in ASCC. Further trials with a larger patient population are warranted in order to evaluate the potential role of consolidation chemotherapy.
Elastohydrodynamic Lubrication of Spherical Surfaces of Low Elastic Modulus (1976)

The paper presents a numerical solution for the elastohydrodynamic lubrication of low modulus point contacts which is broadly equivalent to the theory of Grubin for materials of high elastic modulus. The theoretical results obtained for the variation of minimum film thickness using this approach are therefore expected to apply to conditions of high load and low speed. For less severe conditions in which elastic deformation is less significant an alternative approach has been developed. Results of this analysis show the transition from undeformed to heavily loaded conditions. The effect of lubricant starvation has been examined for heavily loaded conditions and the theoretical results are compared with those obtained previously for high elastic modulus point contact.
A Versatile Method for Functionalizing Surfaces with Bioactive Glycans (2010)

Microarrays and biosensors owe their functionality to our ability to display surface-bound biomolecules with retained biological function. Versatile, stable, and facile methods for the immobilization of bioactive compounds on surfaces have expanded the application of high-throughput "omics"-scale screening of molecular interactions by nonexpert laboratories. Herein, we demonstrate the potential of simplified chemistries to fabricate a glycan microarray, utilizing divinyl sulfone (DVS)-modified surfaces for the covalent immobilization of natural and chemically derived carbohydrates, as well as glycoproteins. The bioactivity of the captured glycans was quantitatively examined by surface plasmon resonance imaging (SPRi). Composition and spectroscopic evidence of carbohydrate species on the DVS-modified surface were obtained by X-ray photoelectron spectroscopy (XPS) and time-of-flight secondary ion mass spectrometry (ToF-SIMS), respectively. The site-selective immobilization of glycans based on relative nucleophilicity (reducing sugar vs amine- and sulfhydryl-derived saccharides) and anomeric configuration was also examined. Our results demonstrate straightforward and reproducible conjugation of a variety of functional biomolecules onto a vinyl sulfone-modified biosensor surface. The simplicity of this method will have a significant impact on glycomics research, as it expands the ability of nonsynthetic laboratories to rapidly construct functional glycan microarrays and quantitative biosensors.
Adapting object-communication methods dynamically (1995)

When objects migrate or are reused, they must find suitable existing objects and establish communication with them. The authors describe the first stage of Omega, a model that lets developers dynamically adjust object-communication methods so that new and existing objects can exchange messages.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Fast disparity estimation using geometric properties and selective sample decimation for stereoscopic image coding (1999)

This paper present a fast disparity estimation algorithm based on limited range, directional search and selective sample decimation is presented. The proposed algorithm has focused on reduction of complexity while retaining good objective performance. The simulation results show: that complexity can be significantly reduced while the PSNR for Y, Cb and Cr is close to the one of full search. In addition, the entropy for disparity vectors is reduced compared to the one of full search.
Time-efficient, high-resolution, whole brain three-dimensional macromolecular proton fraction mapping (2015)

The proposed synthetic reference method improves resolution of MPF mapping and combines accurate MPF measurements with unique neuroanatomical contrast features.
A CONVENIENT SYNTHESIS OF DIETHYL (MERCAPTOMETHYL)PHOSPHONATE (1989)

(1989). A CONVENIENT SYNTHESIS OF DIETHYL (MERCAPTOMETHYL)PHOSPHONATE. Organic Preparations and Procedures International: Vol. 21, No. 3, pp. 390-392.
An Improvement in the Preparation of Acids via Acetoacetic Ester (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAn Improvement in the Preparation of Acids via Acetoacetic EsterJohn J. Ritter and Thaddeus J. KanieckiCite this: J. Org. Chem. 1962, 27, 2, 622–623Publication Date (Print):February 1, 1962Publication History Published online1 May 2002Published inissue 1 February 1962https://pubs.acs.org/doi/10.1021/jo01049a501https://doi.org/10.1021/jo01049a501research-articleACS PublicationsRequest reuse permissionsArticle Views408Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Cesium Exchange Properties of Vermiculite (1962)

Although direct disposal to the ground has provided an effective means for the disposal of low- and intermediate-level waste streams, there is concern regarding the lack of control of the radionuclides once the wastes have been discharged to the ground. The use of a mineral-filled column is regarded as an inexpensive, yet efficient, alternative method for waste decontamination. For this purpose the cesium-exchange properties of various grades of commercially available vermiculite were investigated and compared to other natural ion-exchange materials. Elucidation of the reaction mechanism has led to improvement of the cesium-sorptive properties, either by potassium treatment or heat treatment of the vermiculite or by addition of potassium to the waste stream. Studies of the kinetics and the thermodynamics of the exchange reaction permit extrapolation of the data for consideration of the extended use of vermiculite columns for decontaminating other waste streams. Data obtained from bench-scale and field-scale (10-ft long, 2-in. i.d.) column studies compare closely with those obtained by slurry studies. The breakthrough curves obtained were sufficiently steep to indicate that the partial cesium-sorptive capacity of a vermiculite column would be completely utilized if two columns were operated in series. A column 10 ft long and 10 ft in diameter filled with Na-treated vermiculite is estimated to be capable of decontaminating more than 5 × 105 gal of ORNL intermediate-level waste. Larger volumes of waste streams having lower concentrations of stable salts could be decontamined with respect to cesium and strontium.
An Amperometric Microsensor for the Determination of H<sub>2</sub>S in Aquatic Environments (1996)

A new amperometric microsensor for detection of dissolved H2S in aquatic environments was developed. The design of the microsensor is based on the same principle as the Clark-type oxygen microsensor. The sensor is equipped with a glass-coated platinum working electrode and a platinum guard electrode positioned in an outer glass casing (tip diameter 20−100 μm). Both working electrode and guard electrode were polarized at a fixed value in the range from +85 to + 150 mV with respect to a counter electrode. The outer casing is sealed with a thin silicone membrane and filled with a buffered electrolyte solution containing ferricyanide (K3[Fe(CN)6]) as redox mediator. Hydrogen sulfide penetrates the silicone membrane and is oxidized by K3[Fe(CN)6], resulting in the formation of elemental sulfur and ferrocyanide (K4[Fe(CN)6]). The latter is electrochemically reoxidized at the exposed end of the platinum working electrode, thereby creating a current that is directly proportional to the dissolved H2S concentration at the sensor tip. The sensor was characterized and calibrated in a flow-through cell combined with a coulometric sulfide generator. Difficult studies including the determination of H2S with high spatial and temporal resolution seem to be possible.
One-Dimensional Mass-Spring Chains Supporting Elastic Waves with Non-Conventional Topology (2016)

There are two classes of phononic structures that can support elastic waves with non-conventional topology, namely intrinsic and extrinsic systems. The non-conventional topology of elastic wave results from breaking time reversal symmetry (T-symmetry) of wave propagation. In extrinsic systems, energy is injected into the phononic structure to break T-symmetry. In intrinsic systems symmetry is broken through the medium microstructure that may lead to internal resonances. Mass-spring composite structures are introduced as metaphors for more complex phononic crystals with non-conventional topology. The elastic wave equation of motion of an intrinsic phononic structure composed of two coupled one-dimensional (1D) harmonic chains can be factored into a Dirac-like equation, leading to antisymmetric modes that have spinor character and therefore non-conventional topology in wave number space. The topology of the elastic waves can be further modified by subjecting phononic structures to externally-induced spatio-temporal modulation of their elastic properties. Such modulations can be actuated through photo-elastic effects, magneto-elastic effects, piezo-electric effects or external mechanical effects. We also uncover an analogy between a combined intrinsic-extrinsic systems composed of a simple one-dimensional harmonic chain coupled to a rigid substrate subjected to a spatio-temporal modulation of the side spring stiffness and the Dirac equation in the presence of an electromagnetic field. The modulation is shown to be able to tune the spinor part of the elastic wave function and therefore its topology. This analogy between classical mechanics and quantum phenomena offers new modalities for developing more complex functions of phononic crystals and acoustic metamaterials.
Screening tests for bacteriuria. A validity study (1967)

An evaluation of numerous reported studies indicated that the most useful screening tests for significant bacteriuria appear to be a nitrite test (modified by adding nitrate and incubating at 37 C), the triphenyltetrazolium chloride (TTC) test, and microscopic examination for bacteria. A study of 1,151 urine specimens submitted for routine culture showed that microscopic examination of the centrifuged deposit for organisms or pus cells, or both, was a more sensitive test for significant bacteriuria than the modified nitrite test. Microscopic examination detected 98% of 175 urine specimens with significant gram negative bacilluria, and 17 of 20 with significant numbers of gram positive cocci. The false positive rate was 13%. Microscopy may be better than the chemical screening tests in the selection of urine specimens for cultural examination.
Batching and Optimal Multi-Stage Bipartite Allocations (Extended Abstract) (2021)

In several applications of real-time matching of demand to supply in online marketplaces, the platform can allow for some latency to batch the demand and improve the matching’s efficiency. Motivated by these scenarios, we study the optimal trade-off between batching and inefficiency in online allocations. In particular, we consider K-stage variants of the classic vertex weighted bipartite b-matching and AdWords problems, where online vertices arrive in K batches. Our main result for both problems is an optimal (1-(1-1/K)^K)-competitive (fractional) matching algorithm, improving the classic (1-1/e) competitive ratios known for the online variant of these problems [Mehta et al., 2007; Aggarwal et al., 2011]. Our main technique is using a family of convex-programming based matchings that distribute the demand in a particularly balanced way among supply in different stages. More precisely, we identify a sequence of polynomials with decreasing degrees that can be used as strictly concave regularizers of the optimal matching linear program to form this family. By providing structural decompositions of the underlying graph using the optimal solutions of these convex programs, we develop a new multi-stage primal-dual framework to analyze the fractional multi-stage algorithm that returns the corresponding regularized optimal matching in each stage (by solving the stage’s convex program). We further show a matching upper-bound by providing an unweighted instance of the problem in which no online algorithm obtains a competitive ratio better than (1-(1-1/K)^K). We extend our results to integral allocations in the vertex weighted b-matching problem with large budgets, and in the AdWords problem with small bid over budget ratios.
High-Resolution Crystal Structure of the Snake Venom Metalloproteinase BaP1 Complexed with a Peptidomimetic: Insight into Inhibitor Binding (2009)

BaP1, a zinc-dependent endopeptidase belonging to the P-I class of snake venom metalloproteinases, exerts multiple tissue-damaging activities, leading to hemorrhage, myonecrosis, dermonecrosis, blistering, and edema. Interestingly, this metalloproteinase shows a high degree of structural homology with the catalytic domain of human adamalysins and matrix metalloproteinases, especially at the strictly conserved zinc binding motif and the so-called Met turn. This highlights BaP1 as an interesting model concerning inhibitor design for several medicinally important metalloproteinases, such as tumor necrosis factor alpha converting enzyme. Here, we report the first crystal structure of BaP1 complexed with a peptidomimetic inhibitor. Suitable crystals were obtained at four different pH values (4.6, 6.5, 7.5, and 8.0), and four high-resolution structures (1.46, 1.14, 1.08, and 1.05 A) were established. These structures and the detailed analysis of the structure-activity relationship of the bound inhibitor form a basis for the design of potent BaP1 inhibitors. The latter can be used for the treatment of local pathological effects caused by snake bites, mainly due to metalloproteinases such as BaP1. Besides, the high-resolution structure is an excellent starting point for the rational development of inhibitors for human metalloproteinases. The finding of a flexible loop region may have a great impact on further studies as to date little is known about the structural dependencies of the hemorrhagic activity of snake venom metalloproteinases.
Close-packed structures of spheres of two different sizes I. Observations on natural opal (1980)

Abstract An unusual sample of gem opal has been found to contain silica spheres of two different sizes, mixed in various proportions. Electron micrographs show extensive areas of long-range order. The structures of two different ordered phases, corresponding to compounds AB2 and AB13, have been deduced from the micrographs. Their calculated densities are found to be greater than that of the two separate components in a close-packed regular arrangement.
Refractory Esophageal Strictures: What To Do When Dilation Fails (2015)

Benign esophageal strictures arise from a diversity of causes, for example esophagogastric reflux, esophageal resection, radiation therapy, ablative therapy, or the ingestion of a corrosive substance. Most strictures can be treated successfully with endoscopic dilation using bougies or balloons, with only a few complications. Nonetheless, approximately one third of patients develop recurrent symptoms after dilation within the first year. The majority of these patients are managed with repeat dilations, depending on their complexity. Dilation combined with intra lesional steroid injections can be considered for peptic strictures, while incisional therapy has been demonstrated to be effective for Schatzki rings and anastomotic strictures. When these therapeutic options do not resolve the stenosis, stent placement should be considered. Self bougienage can be proposed to a selected group of patients with a proximal stenosis. As a final step surgery is an option, but even then the risk of stricture formation at the anastomotic site remains. This chapter reviews refractory benign esophageal strictures and the treatment options that are currently available.
Characterization of single-mode optical fiber filters (1981)

The fabrication of narrowband highly reflecting filters in single-mode step-index fibers was reported recently by Hill et al. [Appl. Phys. Lett. 32, 647 (1978)]. The underlying effect on which these filters are based is a photoinduced refractive-index change in the GeO(2) used as a core dopant in SiO(2) fibers. A study is reported aimed at the characterization of such optical fiber filters. A theoretical model is developed, and relevant fiber parameters are determined through intercomparison with experiment. In this way, both the magnitude of the photoinduced index change and its dependence on the writing power coupled into the fiber are determined.
Silver or silver nanoparticles: a hazardous threat to the environment and human health? (2008)

Nanotechnology is a rapidly growing science of producing and utilizing nano-sized particles that measure in nanometers. These nanomaterials are already having an impact on health care. Now-a-days we are using nanoproducts in various fields. Of these, silver nanoparticles are playing a major role in the field of nanotechnology and nanomedicine.Their unique size-dependent properties make these materials superior and indispensable as they show unusual physical, chemical and biological properties. Silver nanoparticles have potential antimicrobial activity towards many pathogenic microbes. Along with this antimicrobial activity, silver nanoparticles are showing unacceptable toxic effects on human health and the environment. The chronic exposure to silver causes adverse effects such as permanent bluish-grey discoloration of the skin (argyria) and eyes (argyrosis). Besides argyria and argyrosis, exposure to soluble silver compounds may produce other toxic effects like liver and kidney damage, irritation of the eyes, skin, respiratory and intestinal tract and changes to blood cells. This review summarizes the hazardous effects of silver nanoparticles in the environment and theirs toxic effects on human health.