gebhart/patrepeval huggingface dataset:
The CD4-associated Tyrosine Kinase p56 Is Required for Lymphocyte Chemoattractant Factor-induced T Lymphocyte Migration (1995)

Lymphocyte chemoattractant factor (LCF) is a polypeptide cytokine which induces both cell motility and activation of T lymphocytes. These LCF-induced events demonstrate an absolute requirement for the cell surface expression of CD4. Because many CD4-mediated T lymphocyte activation events have been demonstrated to require the association of the src-related tyrosine kinase p56lck with the cytoplasmic domain of CD4, we examined the role of p56lck in LCF-induced lymphocyte migration in a murine T cell hybridoma line expressing transfected human CD4. LCF induces the catalytic activity of CD4 associated p56lck at chemoattractant concentrations of cytokine. Hybridoma cells that express CD4 with cytoplasmic point mutations which uncouple the CD4-lck association lack both lck enzymatic activity and chemotactic responses to LCF. The enzymatic activity of lck however does not appear to be required for CD4-mediated migratory signal. First, the protein tyrosine kinase inhibitor herbimycin A blocked LCF-induced p56lck activation but had no effect on the LCF-induced motile response. Second, T cell hybridomas expressing a chimeric receptor combining the extracellular domain of human CD4 and murine p56lck which lacked the kinase domain had a normal LCF-induced motile response. We conclude from these observations that CD4-lck coupling is essential for LCF-induced T lymphocyte migration but the motile response is independent of the enzymatic activity of CD4-associated p56lck.
Verifying the configuration of virtualized network functions in software defined networks (2017)

The deployment of modular virtual network functions (VNFs) in software defined infrastructures (SDI) enables cloud and network providers to deploy integrated network services across different resource domains. It leads to a large interleaving between network configuration through software defined network controllers and VNF deployment within this network. Most of the configuration management tools and network orchestrators used to deploy VNF lack of an abstraction to express Assume-Guarantee contracts between the VNF and the SDN configuration. Consequently, VNF deployment can be inconsistent with network configurations. To tackle this challenge, in this paper, we present an approach to check the consistency between the VNF description described from a set of structural models and flow-chart models and a proposed deployment on a real SDN infrastructure with its own configuration manager. We illustrate our approach on virtualized Evolved Packet Core function.
Determination and Characteristic Analysisof Atmospheric Carbonyl Compoundsin a North China Plain Hub City (2019)

The concentration and variation trend of atmospheric carbonyl compounds in Jinan were first measured during autumn 2017 for three continuous weeks at a 3-h time resolution. A total of 14 types of carbonyls were identified, among which acetone, formaldehyde, and acetaldehyde were the most abundant carbonyls and their concentrations were 3.752.21 ppbv, 2.651.67 ppbv, 1.831.17 ppbv, respectively; formaldehyde and acetaldehyde showed similar diurnal variation trends. Butyraldehyde and isovaleraldehyde were another two important carbonyl compounds with concentrations of 1.050.59 ppbv and 1.040.47 ppbv, respectively. The average C1/C2 ratio was 1.90, which indicated that anthropogenic sources were the main contributor of atmospheric carbonyls. The correlation analysis showed that the measured carbonyls had different sources. Formaldehyde, acetaldehyde, butyraldehyde and isovaleraldehyde were the most important OVOC contributors to OH reactivity and O 3 formation.
Experimental Inhalation of Chlorine Gas Produced with a Different Method; Effects of N-Acetyl Cysteine on Acute Pulmonary Damage (2008)

ABSTRACT The two most common gas inhalation injuries encountered in emergency departments are carbon monoxide and chlorine inhalations. In this study, chlorine was produced through a method different to the previous experimental models. Rats were subjected to inhale chlorine, after which the effects of N-acetylcysteine on pulmonary damage were evaluated. A total of 50 rats were equally divided into five groups. Group 1 received nothing. Groups 2 and 3 were taken as 6 h, groups 4 and 5 as 24 h control and N-acetylcysteine groups, respectively. Firstly, 200 ppm chlorine gas was given for 20 min. Then, 40 mg/kg N-acetylcysteine was given intraperitoneally. The same procedure with the same dose was repeated 3 h later. The same procedures were applied to the control group but this time saline was used. Tissue samples of lungs were taken. Glutathione levels of the rats in the N-acetylcysteine group sacrificed at 24 h were significantly higher than those of the control group. Histopathological evaluation of the pulmonary tissues of the rats sacrificed at 6 and 24 h revealed mild-to-moderate degrees of tissue damage. The degree of tissue damage at 6 h and 24 h N-acetylcysteine group rats was lower than that in the control group. As a result, tissue damage resulting from experimental chlorine inhalation can be alleviated by N-acetylcysteine. This is mainly the result of the antioxidant effects of the N-acetylcysteine.
Cold Fusion as an Interaction Between Ion Band States (1991)

A theory of solid-state fusion based on the interaction between D+ and 4He++ ion band states within a host lattice is presented. Formation of ion band-state deuterium is thermodynamically favored when lattice strain energy is greater than the incremental chemical potential of the band state. The key fusion step is a coalescence fluctuation that converts a two-fold occupation state of electrostatic zero-point-motion size into a state of nuclear dimensions. Rates are calculated using the Fermi Golden Rule. Fusion energy is shared between band-state members and subsequently transferred to the lattice.
Glioma cell migration is associated with glioma‐induced angiogenesis in vivo (1999)

To simultaneously assess glioma cell invasion and glioma angiogenesis in vivo by non-invasive and quantitative means, DiI-labeled C6 glioma spheroids were implanted into the dorsal skinfold chamber preparation of nude mice (n = 6). Heat-inactivated spheroids served as controls to distinguish between active and passive cell spread. Using multi-fluorescent intravital videomicroscopy, glioma cell migration was analyzed on days 1-4, 6, and 10 and spheroid vascularization was analyzed on days 3, 6, and 10 after implantation. Additionally, C6 glioma spheroids were implanted into the chronic cranial window of nude mice as an orthotopic implantation site (n = 4). In the dorsal skinfold chamber, spheroids were vascularized within 10 days and revealed a tumor-specific microvasculature. In parallel, individual glioma cells detached from the spheroid edge and migrated centrifugally demonstrating an affinity to tumor and host vessels. Glioma cells demonstrated a heterogeneous pattern of their regional migratory activity (0.2-9.6 microm/h) which correlated well with regional glioma angiogenesis (r = 0.733). Using the cranial window, glioma cells spread similarly demonstrating an affinity to the perivascular space of pial/subpial vessels with preference to the arteriolar segments. Intravital fluorescence microscopy represents a versatile technique to assess the complex relationship between glioma-driven angiogenesis and glioma cell invasion.
ortho-Metalation/chlorination of benzoic acid derivatives: preparation of [benzene-U-13C]-rac-clopidogrel ([benzene-U-13C]-rac-SR25990C) (2000)

Directed ortho-lithiation is used to form [benzene-U-13C]-2-chlorobenzaldehyde, the key building block for preparation of labelled racemic Clopidogrel ([benzene-U-13C]-rac-SR25990C). Some practical observations are reported concerning the metalation of some derivatives of benzoic acid. Copyright © 2000 John Wiley & Sons, Ltd.
Tomorrow's Gene Therapy Suggests Plenteous, Patent Cardiac Vessels (1992)

CLEARING a blocked coronary artery, ensuring that it doesn't clog up again, and engendering collateral blood vessels for extra circulatory protection may all become one simple procedure when gene therapy is applied to the human heart. This is one near-future possibility sketched by Jeffrey M. Leiden, MD, PhD, chief of cardiology, University of Chicago (Ill) Pritzker School of Medicine, at the 65th annual scientific sessions of the American Heart Association, in New Orleans, La. <h3>Somatic Gene Therapy</h3> Leiden, who is also professor of medicine and pathology, and his colleagues are among the pioneers of somatic gene therapy for cardiovascular disease. Somatic gene therapy, in which normal copies of genes are introduced into the appropriate cells of an individual to treat a specific disorder by replacing abnormal genes, can be thought of as just a new type of pharmacologic treatment. It carries none of the ethical burden of germ-line gene therapy,
One-junction superconducting memory cell with column sense (1995)

A superconducting memory cell consisting of one Josephson junction and one inductor and using a column-sense technique is demonstrated to make very dense memory possible. Information is stored in the inductor in the form of a single flux quantum by applying bipolar x and y selection signals. For readout, a voltage pulse generated from the cell propagates along the column using a structure equivalent to a Josephson transmission line. It is accomplished by inserting a dc-biased junction in the column for every group of four or eight cells. Dense memory arrays are possible because the cell is the simplest flux storage cell and contains no sense gate. An experimental memory array has been demonstrated with sense margin of /spl plusmn/22% and cell size of 54 squares. (A square is the normalized area to the minimum junction size.) This is a factor of two smaller than the miniaturized cells reported recently with 121, 98, and 80 squares.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Localization of DNA sequences involved in dexamethasone-dependent expression of the rat alpha 1-acid glycoprotein gene. (1986)

Synthesis of rat alpha 1-acid glycoprotein (AGP), one of the major inflammation-induced plasma proteins, is positively regulated by dexamethasone. To define the dexamethasone-responsive genetic element, we isolated and tested AGP gene sequences for the ability to confer glucocorticoid induction to the bacterial chloramphenicol acetyltransferase (CAT) gene in L cells. A 141-base-pair region of the AGP gene, including 120 base pairs of DNA upstream from the start site of transcription and 21 base pairs of the 5' untranslated region, was sufficient for maximal CAT gene induction by dexamethasone. To localize more precisely the AGP glucocorticoid-responsive element, parts of this 141-base-pair region were inserted 5' to either an AGP promoter-CAT gene or a human triosephosphate isomerase promoter-CAT gene, both of which lacked a response to the steroid. The AGP gene region between 120 and 42 base pairs upstream from the start site of transcription was found to mediate maximal dexamethasone induction of CAT enzyme levels. This result was unexpected because this region does not contain sequence homologies to known glucocorticoid receptor-binding sites and those AGP gene regions that lay further upstream and were homologous to other glucocorticoid receptor-binding sites were inactive in the CAT assay. The fact that the AGP gene region mediating dexamethasone regulation was distinct from the transcribed region indicates that glucocorticoids increase AGP gene expression primarily at the transcriptional rather than the posttranscriptional level.
An NLP-based cognitive system for disease status identification in electronic health records (2017)

This paper presents a natural language processing (NLP) based cognitive decision support system that automatically identifies the status of a disease from the clinical notes of a patient record. The system relies on IBM Watson Patient Record NLP analytics and supervised or semi-supervised learning techniques. It uses unstructured text in clinical notes, data from the structured part of a patient record, and disease control targets from the clinical guidelines. We evaluated the system using de-identified patient records of 414 hypertensive patients from a multi-specialty hospital system in the U.S. The experimental results show that, using supervised learning methods, our system can achieve an average 0.86 F1-score in identifying disease status passages and average accuracy of 0.77 in classifying the status as controlled or not. To the best of our knowledge, this is the first system to automatically identify disease control status from clinical notes.
3D game engine programming (2004)

Introduction Part I: Introduction to the Topics 1. 3D Engines and Game Programming 2. Designing the Engine 3. Engineering the Engine 4. Fast 3D Calculus Part II: Rendering Graphics 5. Materials, Textures, and Transparency 6. The Render Device of the Engine 7. 3D Pipelines and Shaders 8. Loading and Animating 3D Models Part III: Support Modules for the Engine 9. The Input Interface of the Engine 10. The Audio Interface of the Engine 11. The Network Interface of the Engine 12. Timing and Movement in the Engine 13. Scene Management Part IV: Black Art of Game Programming 14. Computer-Aided Design (CAD) Tools 15. Deathmatch Shooter
Luminescence of Divalent Europium in Ba-Ca, Ba-Sr, and Ca-Sr Orthophosphate and Pyrophosphate Compositions (1970)

Divalent europium was used as an activator in Ba‐Ca, Ba‐Sr, and Ca‐Sr orthophosphate and pyrophosphate compositions. Luminescence was observed in most of the compositions and spectral energy distribution measurements were made on all samples. Changes in the mixed cation ratios produced variations in emission band intensities, shifting of emission peak positions, and changes in emission band widths A new compound with the formula was found.
On-Chip Detection of Process Shift and Process Spread for Silicon Debugging and Model-Hardware Correlation (2012)

This paper proposes the use of ROs (Ring Oscillators) for process shift and process spread detection for silicon debugging and model-hardware correlation. ROs are designed to be sensitive to either nMOSFET orpMOSFET variation, thus the location of the chip in the process spacecan be detected directly from the RO measurements. Test chip measurements in a 65-nm process shows the validity of the proposed ROs. Amounts of process shift and process spread for key process parameters as threshold voltages and gate length are extracted from test chip measurements.
Hetarenes IV (1997)

This second of five volumes covers the chemistry of six-membered hetarenes, with two or more heteroatoms (oxygen, sulfur, nitrogen) which are treated in the order as given by the IUPAC priority rules. However, compounds with an annulated (hetero)-aromatic ring are covered following, in each case, the parent monocycle. Moreover, all types of larger hetero-rings with maximum unsaturation are included. The Methods in Organic Chemistry series is designed as a resource for the synthetic chemist, providing handbooks for preparative methods in organic chemistry organized according to the class of compound or functional group to be synthesized. It gives the synthetic chemist and pharmacist a rational overview of important preparative methods for various classes of compounds. The preparative significance of the methods is critically evaluated and the scope of application carefully designed and illustrated in detail. International in scope, the series presents a rational overview of the important preparative methods for all classes of compounds. The reader is enabled to inform him or herself, acquire suggestions for syntheses and find practical solutions for their problems without time-consuming and extensive research. To ensure that all chemists are able to benefit, the procedures and tables are presented in internationally recognized terms and symbols. All studies, whether from the USA, the Commonwealth of Independent States or any other country, are carefully considered and meticulously reported.
[A model of an in vitro biological assay controlled by immunofluorescence and scanning electron microscopy]. (1991)

This study was designed to complete the cell culture test for the cytotoxicity assessment of dental material presented by Christen et al. (1989) and Regad et al. (1989). Two liner materials were selected for this experiment which had already been subjected to both in vivo and in vitro tests. After 2, 7 and 14 days of contact with the test materials, the cell responses were evaluated under the light microscope by their growth pattern and morphological aspects. Cell synthesis of fibronectin and type I and III collagen was studied by immunofluorescence. Surface appearance of the cells in contact with the materials as well as their structures were observed by scanning electron microscopy. This study confirmed the viability of the in vitro cytotoxicity assessment methods with cell cultures. The results also demonstrated the potentials of this method in the early screening of dental materials for their biological compatibility.
Human Clinical-Grade Parthenogenetic ESC-Derived Dopaminergic Neurons Recover Locomotive Defects of Nonhuman Primate Models of Parkinson's Disease (2018)

Clinical application of stem cell derivatives requires clinical-grade cells and sufficient preclinical proof of safety and efficacy, preferably in primates. We previously successfully established a clinical-grade human parthenogenetic embryonic stem cell (hPESC) line, but the suitability of its subtype-specific progenies for therapy is not clear. Here, we compared the function of clinical-grade hPESC-derived midbrain dopaminergic (DA) neurons in two canonical protocols in a primate Parkinson's disease (PD) model. We found that the grafts did not form tumors and produced variable but apparent behavioral improvement for at least 24 months in most monkeys in both groups. In addition, a slight DA increase in the striatum correlates with significant functional improvement. These results demonstrated that clinical-grade hPESCs can serve as a reliable source of cells for PD treatment. Our proof-of-concept findings provide preclinical data for China's first ESC-based phase I/IIa clinical study of PD (ClinicalTrials.gov number NCT03119636).
Effect of an Enteric-Coated Fish-Oil Preparation on Relapses in Crohn's Disease (1996)

In patients with Crohn's disease in remission, a novel enteric-coated fish-oil preparation is effective in reducing the rate of relapse.
Adsorption Equilibria and Kinetics of Propane and Propylene in Silica Gel (2001)

Adsorption equilibrium isotherms for propane and propylene on narrow pore silica gel (NSG) and wide pore silica gel (WSG) were measured by gravimetry in the temperature range 303−343 K and at pressures up to 101 kPa. The isotherms were correlated by the generalized Dubinin isotherm and Polanyi's theory. Both adsorbents have a higher affinity for propylene. The loading at 100 kPa of propylene is 2 and 0.7 mmol/g on NSG and WSG, respectively. These loadings are 1.5 higher than those for propane with both adsorbents. The heat of adsorption estimated by the Clausius−Clapeyron equation decreases with the degree of coverage. Adsorption kinetics in the same temperature range was studied by the zero-length column method using the long time response. The diffusion of propane and propylene in both silicas is controlled by Knudsen diffusion. The pore diffusivities determined in the temperature range 303−343 K are 2.4 × 10-3−2.8 × 10-3 and 1.7 × 10-3−2.4 × 10-3 cm2/s for propane and propylene on NSG, respectively. For WSG these values are 6.4 × 10-3−9.9 × 10-3 cm2/s for propane and 6.6 × 10-3−12.1 × 10-3 cm2/s for propylene. Average tortuosity factors of 2.5 for NSG and 2.0 for WSG were obtained.
Factors Affecting Adoption of B2E E-Business Systems: A Case of the Australian Higher Education Industry (2007)

In recent years, there has been a surge in the number of organizations wanting to embrace IT systems that support the notion of business-to-employee (B2E) e-business. Trade magazines are now filled with many short essays and case reports highlighting the benefits of B2E e-business systems. However, little is reported in the scholarly academic literature about the adoption of B2E e-business systems. Thus, it is not clearly known what factors facilitate the decision of large organizations to adopt these systems. Given the fact that higher educational institutions maintain a large workforce, it is important to determine the conditions that affect their decisions to adopt B2E systems. This study reports on the employee portal adoption experience of two large Australian universities and identifies the key factors that influenced their decisions to adopt these systems. The implications of the findings are also discussed.
A phase I study of the safety, tolerability, and pharmacokinetics of intravenous XMT-1001 in patients with advanced solid tumors. (2007)

A146 XMT-1001 is a water soluble macromolecular conjugate of camptothecin (CPT). In this novel CPT pro-drug, CPT is conjugated with a 70 kDa biodegradable hydrophilic polyacetal, poly (1-hydroxymethylene hydroxlmethylformal). XMT-1001 has demonstrated an improved therapeutic window than CPT and irinotecan in human tumor xenografts models (Yurkovetskiy AV et al. Mol. Pharm 1:375, 2004; Yurkovetskiy AV et al. AACR; 2007, Abstract #781), providing a compelling rationale for clinical development. Objectives: The objectives of the ongoing phase I study are: 1.to determine the maximum tolerated dose (MTD) of XMT-1001; 2. to assess the safety and tolerability of XMT-1001; 3. to assess the pharmacokinetics (PK) of XMT-1001 and its release products; 4. to assess for evidence of anti-tumor activity of XMT-1001. Methods: This is an open label, dose escalation study of XMT-1001 administered intravenously (IV) over 30 minutes every 21 days. Initially three patients are entered at each dose level. The cohort is expanded to six patients if a patient experiences a dose limiting toxicity (DLT). Analyses of plasma and urine were performed for total CPT, conjugated CPT, unconjugated (free) CPT, and two major CPT pro-drugs, camptothecin-20-N-succinimidoglycinate (CPT-SI) and camptothecin-20-N-succinamidoglycinate (CPT-SA) using validated assays. Pharmacokinetic analysis was performed using WinNonlin Professional Edition (Pharsight Corp.,Version 4.1). Results: To date, patients (pts) have been treated with XMT-1001 at 1.0 mg CPT equivalents/m 2 (3 pts, 7 cycles), 1.8 mg CPT equivalents/m 2 (3 pts, 4 cycles), and 3.1 mg CPT equivalents/m 2 (1 pt, 1 cycle). There were no drug related serious adverse events (SAEs). One patient with non-small cell lung cancer treated at 1.0 mg CPT equivalents/m 2 had stable disease lasting six weeks. Preliminary pharmacokinetic parameters in the initial patient in the study revealed a biphasic profile for total CPT and conjugated CPT, with T ½ α equal to 2 hours (h) and T ½ β equal to10 h. In this patient, 24 h recovery in urine for total CPT and free CPT was about 8.8% and 0.7% of the administered CPT dose, respectively. Formation of the CPT releasing camptothecin pro-drugs CPT-SI and CPT-SA as well as free CPT in plasma and urine were confirmed. Characteristic PK parameters of XMT-1001 and its release products in plasma and urine will be presented. Conclusions : 1. XMT-1001 was well tolerated and patients have not experienced drug related SAEs. 2. Preliminary results demonstrate favorable PK with low levels of CPT (both total and free) recovered in urine. 3. The phase I study continues to accrue patients and the MTD has not been reached.