gebhart/patrepeval huggingface dataset:
Controlled arrangement of self-organized Ge islands on patterned Si (001) substrates (1999)

We report the ability to arrange self-organized Ge islands on patterned Si (001) substrates. Selective epitaxial growth of Si is carried out with gas-source molecular beam epitaxy to form Si mesas followed by subsequent Ge growth. Self-aligned and regularly spaced Ge islands are formed on the 〈110〉-oriented ridges of the Si stripe mesas. A mono-modal size distribution of the islands has been observed on the ridges. Using preferential nucleation sites allows us to place Ge islands at predetermined positions. The controlled arrangement of self-organized nanostructures offers the potential applications of island arrays for the implementation in nanoelectronics and quantum computation.
Identification of Common Genetic Variation That Modulates Alternative Splicing (2007)

Alternative splicing of genes is an efficient means of generating variation in protein function. Several disease states have been associated with rare genetic variants that affect splicing patterns. Conversely, splicing efficiency of some genes is known to vary between individuals without apparent ill effects. What is not clear is whether commonly observed phenotypic variation in splicing patterns, and hence potential variation in protein function, is to a significant extent determined by naturally occurring DNA sequence variation and in particular by single nucleotide polymorphisms (SNPs). In this study, we surveyed the splicing patterns of 250 exons in 22 individuals who had been previously genotyped by the International HapMap Project. We identified 70 simple cassette exon alternative splicing events in our experimental system; for six of these, we detected consistent differences in splicing pattern between individuals, with a highly significant association between splice phenotype and neighbouring SNPs. Remarkably, for five out of six of these events, the strongest correlation was found with the SNP closest to the intron-exon boundary, although the distance between these SNPs and the intron-exon boundary ranged from 2 bp to greater than 1,000 bp. Two of these SNPs were further investigated using a minigene splicing system, and in each case the SNPs were found to exert cis-acting effects on exon splicing efficiency in vitro. The functional consequences of these SNPs could not be predicted using bioinformatic algorithms. Our findings suggest that phenotypic variation in splicing patterns is determined by the presence of SNPs within flanking introns or exons. Effects on splicing may represent an important mechanism by which SNPs influence gene function.
Cracking the Code (1992)

How extensive is your knowledge of the Mental Health Act?After nearly a decade of working with this piece of legislation, psychiatric nurses and others caring for the mentally ill now have a Code of Practice to explain how it should be used.Unfortunately, like the Mental Health Act, the Code does not make easy bedtime reading.
Hematologic Aspects of HIV/AIDS (2001)

This review addresses various aspects of HIV infection pertinent to hematology, including the consequences of HIV infection on specific aspects of hematopoiesis and an update on the current biologic, epidemiologic and therapeutic aspects of AIDS-related lymphoma and Hodgkin's disease. The results of the expanding use of progenitor cell transplantation in HIV infected patients are also reviewed. In Section I, Dr. Scadden reviews the basis for HIV dysregulation of blood cell production, focusing on the role of the stem cell in HIV disease. T cell production and thymic function are discussed, with emphasis placed upon the mechanisms of immune restoration in HIV infected individuals. Results of clinical and correlative laboratory studies are presented. In Section II, Dr. Levine reviews the recent epidemiologic trends in the incidence of lymphoma, since the widespread availability of highly active anti-retroviral therapy (HAART). The biologic aspects of AIDS-lymphoma and Hodgkin's disease are discussed in terms of pathogenesis of disease. Various treatment options for these disorders and the role of concomitant anti-retroviral and chemotherapeutic intervention are addressed. Drs. Zaia and Krishnan will review the area of stem cell transplantation in patients with AIDS related lymphoma, presenting updated information on clinical results of this procedure. Additionally, they report on the use of gene therapy, with peripheral blood CD34+ cells genetically modified using a murine retrovirus, as a means to treat underlying HIV infection. Results of gene transfer experiments and subsequent gene marking in HIV infected patients are reviewed.
Studies on novel tri-phthalonitrile phenyl polyhedral oligomeric silsesquioxane and the phthalonitrile–epoxy blends (2015)

A novel tri-phthalonitrile phenyl polyhedral oligomeric silsesquioxane (TPnPh-POSS) was synthesized from trisilanol phenyl POSS and 4-nitrophthalonitrile. The structure of the TPnPh-POSS monomer was characterized by Fourier transform infrared spectroscopy and nuclear magnetic resonance spectroscopy. The phthalonitrile monomer was thermally polymerized with various concentrations (3, 4, and 5 wt%) of 4,4′-diaminodiphenyl sulfone (DDS) as the curing agent. The curing behavior of the monomer was investigated by differential scanning calorimetry. The influence of the content of the curing additive on the polymer properties was studied. Blends of TPnPh-POSS and diglycidyl ether of bisphenol A (epoxy resin) were successfully prepared. The thermal and mechanical properties of these blends with DDS as curing agent were evaluated and compared with the neat epoxy resin. The thermal stability of the cured polymers and epoxy/TPnPh-POSS blends was studied by thermogravimetric analysis. Dynamic mechanical analysis and dielectric studies indicate the influence of TPnPh-POSS content on the relaxation behavior of the prepared blends. The blends exhibit high glass transition temperatures, high storage modulus, and increased thermal stability compared with the commercially available neat epoxy resin. Noncrystalline nature of the cured polymer (with 5 wt% of DDS) was confirmed by X-ray diffraction analysis. The cured polymer shows high flame retardancy, which improved with increase in the amount of the curing additive.
ChemInform Abstract: REVERSIBLE CYCLIZATION OF ORTHO‐BLOCKED N‐ARYLNITROSO IMINES (1976)

Abstract Bei ‐78°C erhält man durch Oxidation der Amidoxime (I) mit Bleitetraacetat in Methylenchlorid die Nitroso‐imine (II), die oberhalb von ‐20°C zu den Oxadiazinen (III) cyclisieren.
A Phase I Study of Chemoembolization with Cisplatin and Lipiodol for Primary and Metastatic Liver Cancer (1994)

Twenty patients with either unresectable primary hepatocellular carcinoma or hepatic metastases were entered into a Chemoembolization program with cisplatin and lipiodol; 19 patients were evaluable for response. Doses of cisplatin ranged from 40 to 100 mg/m2. Toxicity was tolerable and reversible and included abdominal pain, transient elevation in serum creatinine, serum bilirubin, and serum transaminases. Less common side effects include fever, ascites or pleural effusion, and hiccups. Two of four patients with ocular melanoma had partial responses. Duration of response was 10 and 11 months. Among 8 patients with unresectable hepatoma, 2 patients had partial response for 10+ and 13 months, 2 had minor response for 2 months and 4+ months, 1 patient had stable disease for 5+ months, and 3 patients failed to respond. Of the six colon cancer patients treated, one had a partial response in the liver, but developed progressive nodal disease, and another patient had a partial response for 3 months. Chemoembolization of the liver with cisplatin and lipiodol is feasible and doses of cisplatin at least 100 mg/m2 are tolerable. Antitumor activity in metastatic ocular melanoma is encouraging but requires further study.
The nature of opal I. nomenclature and constituent phases (1971)

Abstract Natural hydrous silicas may be subdivided into three well‐defined structural groups—opal‐C (well‐ordered α‐cristobalite), opal‐CT (disordered a‐cristobalite, a‐tridymite) and opal‐A (highly disordered, near amorphous). Lussatite from the original locality is identical with opal‐CT and thus appears to be a legitimate term for this class of opal. Although the prime criterion used is the nature of the X‐ray diffraction pattern, supplementary information from infra‐red absorption, dilatometer and thermal techniques supports the three‐fold classification.
Analysis of LIDAR Data Fused with Co-Registered Bands (2006)

In the past decade, LIght Detection And Ranging (LIDAR) has been recognised by both the commercial and public sector as a reliable and accurate source for land surveying. Object classification in LIDAR data tends towards data fusion by employing additional simultaneously recorded bands. In this paper, a rule-based approach is presented for improving classification accuracy obtained in a supervised Maximum Likelihood classification. Simultaneously recorded co-registered bands are used such as high resolution LIDAR first, last echo and intensity data, aerial and near infra-red photos. Issues regarding feature and class selection and differentiated accuracy assessment are addressed. Furthermore, the individual influence of each band on the classification is investigated. The results show that incorporating additional knowledge and considering contextual relationships among classes is beneficial for improving classification accuracy in fused LIDAR datasets.
Homozygous deletion of MKK4 in ovarian serous carcinoma (2006)

Analysis of deleted chromosomal regions in tumors has historically led to the identification of tumor suppressor genes. In this study, we used digital karyotyping, a genome-wide, high-resolution technology, to search for chromosomal deletions in ovarian serous carcinoma, the most lethal gynecological malignancy in women. Five purified ovarian serous carcinomas were analyzed by digital karyotyping and small interstitial deletions at chromosome 17p were identified in two tumor samples. Aligning these two deletions identified an overlapping region that spanned 2.4 Mb which harbored a candidate tumor suppressor gene, mitogen-activated protein kinase kinase-4 (MKK4). Dual-color FISH analysis confirmed homozygous deletion of the MKK4 locus in both samples and RT-PCR demonstrated that both carcinomas lacked MKK4 transcript expression. Loss of heterozygosity of 17p occurred in 24 (86%) of 28 high-grade serous carcinomas including both cases with homozygous MKK4 deletion. Additionally, downregulation of MKK4 expression was found in 96 (75%) of 128 ovarian serous carcinomas as compared to benign ovarian tissues. These findings suggest that homozygous deletion or reduced expression of MKK4 may contribute to the development of ovarian serous carcinoma.
Optical heterodyne detection of impulsive stimulated Raman scattering in liquids (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOptical heterodyne detection of impulsive stimulated Raman scattering in liquidsYong Joon Chang, Peijun Cong, and John D. SimonCite this: J. Phys. Chem. 1995, 99, 20, 7857–7859Publication Date (Print):May 1, 1995Publication History Published online1 May 2002Published inissue 1 May 1995https://pubs.acs.org/doi/10.1021/j100020a004https://doi.org/10.1021/j100020a004research-articleACS PublicationsRequest reuse permissionsArticle Views394Altmetric-Citations57LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
<title>Optical Heterodyne Profilometer</title> (1983)

An optical heterodyne profilometer breadboard as been developed and demonstrated with surface roughness measurement sensitivity to 0.1 Å. Optical and electronic common-mode rejection techniques were employed in the optical heterodyne precision phase measurement scheme to resolve the optical phase to one part in thirty thousand. Vibration-induced optical phase jitter in the system was nearly eliminated by these common-mode rejection techniques. This non-contact profilometer is capable of characterizing mirror surfaces not limited only to flat and/or highly reflective surfaces. Concaved surfaces such as the x-ray mirrors for the Advanced X-ray Astrophysical Facility (AXAF) may be characterized as well. Several mirror samples have been characterized with the optical heterodyne profil-ometer which include two x-ray mirror samples. Roughness measurement results on the x-ray mirror samples have been compared with those measured by other methods.
The purification in high yield and characterization of rat hepatic glucokinase (1976)

A new improved procedure for the purification of rat hepatic glucokinase (ATP-d-glucose 6-phosphotransferase, EC 2.7.1.2) is given. A key step is affinity chromatography on Sepharose-N-(6-aminohexanoyl)-2-amino-2-deoxy-d-glucopyranose. A homogeneous enzyme, specific activity 150 units/mg of protein, is obtained in about 40% yield. The molecular weight of the pure enzyme was determined by several procedures. In particular, sedimentation-equilibrium studies under a variety of conditions indicate a molecular weight of 48000 and no evidence for dimerization; reports in the literature of other values are discussed in the light of this evidence on the pure enzyme. The amino acid composition suggests that hepatic glucokinase is closely related to rat brain hexokinase and also the wheat "light" hexokinases.
Docking for an autonomous ocean sampling network (2001)

In this paper, we examine the issues associated with docking autonomous underwater vehicles (AUVs) operating within an Autonomous Ocean Sampling Network (AOSN). We present a system based upon an acoustic ultrashort baseline system that allows the AUV to approach the dock from any direction. A passive latch on the AUV and a pole on the dock accomplish the task of mechanically docking the vehicle. We show that our technique for homing is extremely robust in the face of the two dominant sources of error-namely the presence of currents and the presence of magnetic anomalies. Our strategy for homing is independent of the initial bearing of the dock to the AUV, includes a method for detecting when the vehicle has missed the dock, and automatically ensures that the AUV is in a position to retry homing with a greater chance of success. Our approach is seen to be extremely successful in homing the vehicle to the dock, mechanically attaching itself to the dock, aligning inductive cores for data and power transfer, and undocking at the start of a fresh mission. Once the AUV is on the dock, we present a methodology that allows us to achieve the complex tasks with ensuring that the AUV is securely docked, periodically checking vehicle status, reacting to a vehicle that requires charging, tracking it when it is out on a mission, archiving and transmitting via satellite the data that the AUV collects during its missions, as well as providing a mechanism for researchers removed from the site to learn about vehicle status and command high-level missions. The dock is capable of long-term deployments at a remote site while respecting the constraints - low power, small size, low computational energy, low bandwidth, and little or no user input - imposed by the amalgamation of acoustic, electronic and mechanical components that comprise the entire system.
자궁근종 환자의 자궁적출경험 (1999)

【This study is designed to describe and analyze experiences of hysterectomy. It also attempts to develop practical theory of their experiences and thus suggest a fundamental frame that can help nurses broaden their clinical understanding of hysterectomy patients and take better care. The data was collected through interviewing selected subjects. The subjects were five hysterectomy patients. They were interviewed at first hand by this researcher and recorded under their permissions. Each interview took one hour or two hours per interviewer. The data was collected through interview. The method of the Ground Theory by Strauss & Corbin (1990) was used for data analysis. A total of 129 concepts were extracted from data analysis. which were classified into 27 subcategories through reanalysis. The subcategories were grouped under 12 higher categories. During process of data analysis following three propositions repeatedly appeared. (1) The higher importance of sexual life and pregnancy, greater patients' despair. The support system was not satisfied. The closed defense intensified their despair. They felt that operation result was out of control. (2) The lower importance of sexual life and pregnancy, lesser patients' despair. The support system proved to be highly satisfactory. As a result more favorably. (3) The lower physical change, lesser importance of pregnancy. lesser patients' despair, patients' thought turned out to be more positive, which, in turn, left patients less despaired. As a results patients accept operation result more favorably.】
Hydroxyl Radical-Mediated Reduction of Ca2+-ATPase Activity of Masseter Muscle Sarcoplasmic Reticulum (1995)

To understand the effect of oxygen free radicals on Ca(2+)-ATPase, we used sarcoplasmic reticulum (SR) microsomes of canine masseter muscle as a model system in which to explore the effects of oxidation on a biological membrane, and we investigated the effect of hydroxyl radicals (.OH) generated from Fenton's reagent (H2O2/FeSO4). H2O2 (10 mM) alone had no effect on Ca(2+)-ATPase activity; in the presence of FeSO4 (0.2 mM), H2O2 inhibited the enzyme activity. Oxygen free radical species generated from H2O2/FeSO4 under the conditions employed in the Ca(2+)-ATPase assay were verified by highly sensitive electron spin resonance spectroscopy and the spin-trap 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) in the absence of SR vesicles; the 1:2:2:1 quartet (AN = A beta H = 1.49 mT), characteristic of the DMPO-OH spin adduct, was observed. The Ca(2+)-ATPase activity was inversely correlated with the calculated signal intensity of DMPO-OH, which is indicative of the amount of .OH radical generated. The effect of Fenton's reagent was effectively inhibited by catalase, dimethylsulfoxide, and dimethylthiourea; the effect was also inhibited by sulfhydryl (SH) group reducing agents, cysteine and dithiothreitol. The SH group modifying agents, p-chloromercuric benzoate and 5,5'-dithiobis(2-nitrobenzoic acid) depressed Ca(2+)-ATPase activity; the effects of the SH group modifying agents used were potentiated in the presence of Fenton's reagent. It is suggested that .OH radical-induced oxidant injury may be caused primarily by modification of the key SH group(s) on the ATPase molecule of masseter muscle SR vesicles.
Properties of lymphocytes which confer adoptive immunity to tuberculosis in rats. (1973)

Following immunization of rats with BCG there was added to thoracic duct lymph a population of sensitized lymphocytes which conferred adoptive immunity to tuberculosis upon syngeneic recipients. At an early stage of immunization, 5 days after BCG inoculation, the sensitized cells were large and medium lymphocytes as evidenced by their sensitivity to vinblastine. On day 8, the sensitized cell population was partially resistant to vinblastine and by day 28 it was totally resistant. The vinblastine resistant cells have the functional properties of small lymphocytes, since they recirculate freely from the blood to lymph, and can confer long lasting immunity upon recipient rats. The data imply that protective immunity against the tubercle bacillus is transferred by a family of newly-formed lymphocytes, the most immature of which are immunoblasts or large lymphocytes. As the response matures, sensitized small lymphocytes are delivered to the circulation and comprise an increasing proportion of the protective cell population.
Evaluation of high–molecular weight adiponectin in horses (2012)

HMW adiponectin is measurable via ELISA, and concentration is negatively correlated with BCS and serum insulin activity in horses. A greater understanding of the role of adiponectin in equine metabolism will provide insight into the pathophysiology of metabolic disease conditions.
Catch Strip Assay for the Relative Assessment of Two-Dimensional Protein Association Kinetics (2008)

Accurate interpretation of recruitment rate measurements of microscale particles, such as cells and microbeads, to biofunctional surfaces is difficult because factors such as uneven ligand distributions, particle collisions, variable particle fluxes, and molecular-scale surface separation distances obfuscate the ability to link the observed particle behavior with the governing nanoscale biophysics. We report the development of a hydrodynamically conditioned micropattern catch strip assay to measure microparticle recruitment kinetics. The assay exploited patterning within microfluidic channels and the mechanostability of selectin bonds to create reaction geometries that confined a microbead flux to within 200 nm of the surface under flow conditions. Systematic control of capillary action enabled the creation of homogeneous or gradient ligand distributions. The method enabled the measurement of particle recruitment rates (keff, s-1) that were primarily determined by the interaction of the biomolecular pair being investigated. The method is therefore well suited for relative measurements of delivery vehicle and cellular recruitment potential as governed by surface-bound molecules.
Immunogenicity of allograft articular cartilage (1974)

Allograft articular cartilage was transplanted between inbred strains of rats and between rabbits. Three forms of allograft were employed: isolated articular chondrocytes, shavings of articular cartilage, and intact articular surfaces. Immunological assessment with the leukocyte migration technique for cell-mediated immunity and Cr51 cytotoxicity for humoral antibody levels demonstrated that articular chondrocytes possess transplantation antigens and are immunogenic. Moreover, histological evaluation of grafts of shavings of articular cartilage showed round-cell infiltration into the lacunae. If the cartilage matrix was intact, as in intact articular surface grafts, sensitization of hosts did not occur. Sulphur-35 uptake studies revealed that these grafts remain viable even in presensitized recipients, suggesting that humoral antibodies cannot penetrate intact matrix to reach the chondrocytes.
Mouse Flk-1+Sca-1- Mesenchymal Stem Cells (2014)

Flk-1Sca-1 bMSCs have stem cell properties and can efficiently ameliorate the GVHD associated with allogeneic bone marrow transplantation in mice.
Visual tag authoring (2008)

In this work we present a system to encode location based information extracted from a media collection (the Flickr tagging system) into a single 2D physical label. This information is clustered by using locations metadata (geotags) and key-words (tags) associated to pictures. Our system helps two types of users: the user authoring the physical label and the final user who retrieves up-to-date information scanning the label with his/her camera phone. Preliminary results for a given seed word (the tag Napoli) on 3000 photographs are presented, together with some ad-hoc weighting factors that help in finding significant pictures (representing places) that can be associated to a specific area.