gebhart/patrepeval huggingface dataset:
AMH in combination with SHBG for the diagnosis of polycystic ovary syndrome (2019)

Serum Anti-Müllerian hormone (AMH) level could be useful for the diagnosis of polycystic ovary syndrome (PCOS). We evaluated the hormonal status in women for the diagnosis of PCOS. A total of 77 PCOS women and 106 healthy women were enrolled in this study. Serum AMH, gonadotropins [luteinising hormone (LH) and follicle-stimulating hormone (FSH)], oestradiol, testosterone (total and free), 4-androstenedione (ANDST), dehydroepiandrosterone sulphate, sex hormone binding globulin (SHBG), prolactin, thyroid-stimulating hormone and insulin levels were measured in all enrolled women. Our data showed that insulin<sub>,</sub> LH, testosterone, ANDST and AHM levels were significantly higher in the PCOS group and FSH and SHBG levels were lower in the PCOS group. In Receiver operating characteristic analysis, the combination of AMH with SHBG showed higher area under curves (AUC) for PCOS diagnosis with an AUC of 0.843 and a specificity of 81.1% and a sensitivity of 72.7%. Our results suggest that a combination of serum AMH and SHBG levels could be used as a diagnostic biomarker of PCOS. Impact statement <b>What is already known on this subject?</b> Women with PCOS have an increased risk of hypertension, altered glucose metabolism and probably an increased lifetime risk of cardiovascular diseases. There is no consensus on the diagnostic criteria for PCOS. This leads to many patients with PCOS are being undiagnosed. It is known that AMH plays a role in the follicular status of PCOS and serum AMH level is increased significantly in women with PCOS compared with normo-ovulatory women. This is why several studies have suggested the inclusion of AMH as a diagnostic criterion in PCOS. <b>What do the results of this study add?</b> Extensive epidemiological data is available which demonstrates an association between higher AMH levels and PCOS, but there was no information available about the combination of AMH level with other hormones and PCOS. This is the first study that has investigated the association of AMH and SHBG, together, with PCOS. Our results suggest that serum AMH and SHBG level in combination could represent a useful and practical test to screen the general population for PCOS. <b>What are the implications of these findings for clinical practice and/or further research?</b> Many PCOS women in the general population are undiagnosed due to lack of consensus in diagnostic criteria. Therefore, the importance of identifying women with PCOS due to the need for follow-up in short and long-term health risk.
High-resolution adaptive nulling performance for a lightweight agile EHF multiple beam antenna (2002)

The design and experimental performance of a lightweight high-resolution adaptive nulling extremely high-frequency multiple beam antenna (MBA) are addressed. A 127-beam MBA and a four-channel RF nulling network operating over the 43.5-to-45.5-GHz band were used to adaptively null a jammer in anechoic chamber measurements. Lightweight waveguide transmission lines together with ferrite switches were used to select beam ports from the 127-beam MBA. The MBA was designed to provide simultaneous coverage for three communications system users while providing pattern discrimination or nulling of jammers located within 0.1 degrees of the user. Cancellation greater than 30 dB when operating in a wideband mode was experimentally demonstrated.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Crosstalk Study of Simultaneous Wireless Power/Information Transmission Based on an LCC Compensation Network (2017)

The effective simultaneous wireless transmission of power and information (SWTPI) is an issue of great interest. To reduce the crosstalk between power and information channels while increasing the transmission air gap and power level, we introduce an inductor–capacitor–capacitor (LCC) compensation network for an SWTPI system. First, the crosstalk between the power and information channels is analyzed. An effective parametric design method is then proposed for the LCC compensation network, which is analyzed theoretically to minimize the crosstalk. Finally, experiments are conducted at 1000 W and 115.2 kbps with an air gap of 100 cm to verify whether the proposed structure and design method of the LCC compensation network are suitable for the SWTPI.
Coupons: A Multilevel Incentive Scheme for Information Dissemination in Mobile Networks (2008)

Integrating mobile computing and localized user interaction into the Internet requires more than simply overcoming pure routing challenges. Apart from issues such as intermittent connectivity and unreliable nodes, the human factor is becoming increasingly important. To date, user behavior has only been considered in terms of mobility patterns and incentives for encouraging cooperation. Moreover, the focus has always been on systems that aim to enforce fairness by either bringing an indirect equilibrium or by punishing "misbehaving" users. The goal of this paper is therefore to present Coupons. Coupons is an idea to define, evaluate, and implement algorithms for the emerging class of social network and information sharing applications. Coupons is a system designed to allow users to opportunistically interact and share data through a wireless medium, to overcome highly variable Internet access through adaptive localized interaction, and to incorporate an incentive scheme to make the system usable and encourage participation.
Spherical Arrays - Design Considerations (2005)

In this paper we present design trade-offs of array architectures for hemispherical coverage . We show that a spherical array geometry is the optimal choice for this application in terms of performance and cost. It is a natural array geometry that provides scan-independent hemispherical coverage with a uniform gain pattern. We also show that a spherical array requires fewer elements than a comparable multi-planar phased array with significantly larger instantaneous bandwidths, lower polarization and mismatch losses
Mixed Hematopoietic Chimerism for the Simultaneous Induction of T and B Cell Tolerance (2005)

Nonmyeloablative induction of mixed hematopoietic chimerism provides a strategy for inducing T cell tolerance across allogeneic and xenogeneic barriers. We have utilized alpha1-3Gal transferase (GalT) knockout mice, which, like humans, produce anti-Gal natural antibodies, to investigate the ability of mixed chimerism to tolerize B cells producing antibodies of this important specificity, which limits xenotransplantation by causing hyperacute and delayed xenograft rejection. Mixed allogeneic or xenogeneic chimerism indeed tolerizes both preexisting anti-Gal-producing B cells and those developing de novo after establishment of mixed chimerism, even in presensitized mice. We present evidence that different mechanisms are involved in the tolerization of the preexisting and newly-developing antibody-secreting cells.
EIGENVALUES OF SEVERAL TRIDIAGONAL MATRICES (2005)

Tridiagonal matrices appear frequently in mathematical models. In this note, we derive the eigenvalues and the corresponding eigenvectors of several tridiagonal matrices by the method of symbolic calculus in [1]. 1
Spectral characteristics of laser cavities employing multipass grating interferometers as output couplers (1987)

The spectral characteristics of laser cavities terminating in a multipass grating interferometer are investigated. It is shown that, in presence of internal apertures, the frequency profile of the intracavity electric field is characterized by a predominant, very narrow single line that can easily be tuned over spectral intervals that are much larger than the interferometer’s free-spectral range. This is a consequence of the combined action of the interferometer and of the intracavity apertures that select both the transverse mode and a restricted portion of the k space. Experimental evaluation of the spectral behavior of a TEA CO2 laser is reported, and possible application to single-longitudinal-mode operation of broadly tunable lasers is discussed.
The Association of Coloproctology of Great Britain and Ireland consensus guidelines in surgery for inflammatory bowel disease (2018)

These guidelines provide an up to date and evidence based summary of the current surgical knowledge in the management of IBD and will serve as a useful practical text for clinicians performing this type of surgery.
The Serum- and Glucocorticoid-Induced Kinase Is a Physiological Mediator of Aldosterone Action* (2001)

Aldosterone plays a major role in regulating sodium and potassium flux in epithelial tissues such as kidney and colon. Recent evidence suggests that serum- and glucocorticoid-regulated kinase (SGK) is induced by aldosterone and acts as a key mediator of aldosterone action in epithelial tissues. Induction of SGK messenger RNA (mRNA) has previously been shown within 30 min of addition of supraphysiological doses of aldosterone to Xenopus A6 cells and within 4 h in rat kidney in vivo. In this study we determined the time course of SGK induction, at doses of aldosterone in the physiological range, in rat kidney and colon, using Northern and Western blot analyses and in situ hybridization and determined concurrent changes in urinary sodium and potassium excretion by Kagawa bioassay. On Northern blot analysis, SGK mRNA levels were significantly elevated in both kidney and colon 60 min after the injection of aldosterone. SGK protein in late distal colon was significantly elevated 2 and 4 h after aldosterone treatment. In situ hybridization showed SGK mRNA to be induced in renal collecting ducts and distal tubular elements in both cortex and medulla by doses of aldosterone of 0.1 microg/100 g BW or more within 30 min of steroid treatment. Significant changes in urinary composition were similarly seen with an aldosterone dose of 0.1 microg/100 g BW from 90 min after aldosterone injection. The early onset of SGK induction in kidney and colon and the correlation with urinary changes in terms of both time course and dose response suggest that SGK plays an important role in mediating the effects of aldosterone on sodium homeostasis in vivo.
A Proposition of Data Organization and Exchanges to Collaborate in an Autonomous Agent Context (2016)

We live in a world increasingly digital where intelligent and communicating objects evolve and interact. These objects have their own missions and goals. However, in a more and more complex environment, mechanisms of communication and information exchange protocols need to be more efficient, fast and smart. The collaborative approach seems to be the most suitable to facilitate interaction between intelligent entities while preserving their resources by sharing relevant information that will enable them to reach more quickly their goals. For example, collaborative behaviours and informations exchanges could improve the movement of vehicles in an urban center and avoid traffic jams and more globally for all kind of autonomous agent. This article highlights what is a collaboration in the context of communicating autonomous entities. Then we present our architecture that is called HACCA (Hybrid Architecture for Collaborative Communicating Agent). We show the different levels implied in HACCA and we put the stress on the multigraph structure we have created to build and share contextual knowledge. The theory is applied to an example on communication between communicating vehicles.
Characterization of the<i>Aplysia californica</i>Cerebral Ganglion F Cluster (1999)

The cerebral ganglia neurons of Aplysia californica are involved in the development and modulation of many behaviors. The medially located F cluster has been characterized using morphological, electrophysiological and biochemical techniques and contains at least three previously uncharacterized neuronal population. As the three subtypes are located in three distinct layers, they are designated as top, middle, and bottom layer F-cluster neurons (CFT, CFM, and CFB). The CFT cells are large (92 +/- 25 microm), white, nonuniformly shaped, and located partially in the sheath surrounding the ganglion. These neurons exhibit weak electrical coupling, the presence of synchronized spontaneous changes in membrane potential, and a generalized inhibitory input upon electrical stimulation of the anterior tentacular (AT) nerve. Similar to the CFT neurons, the CFM neurons (46 +/- 12 microm) are mainly silent but do not show electrical coupling or synchronized changes in membrane potential. Unlike the CFT neurons, the CFM neurons exhibit weak action potential broadening during constant current injection. Comparison of the peptide profiles of CFT, CFM, and CFB (10-30 microm) neurons using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry demonstrates distinct peptide molecular weights for each neuronal subtype with the masses of these peptides not matching any previously characterized peptides from A. californica. The mass spectra obtained from the AT nerve are similar to the CFT neuron mass spectra, while upper labial nerve contains many peptides observed in the CFM neurons located in nongranular neuron region.
Potent cyclic peptide inhibitors of VLA-4 (?4?1 integrin)-mediated cell adhesion. Discovery of compounds like cyclo(MePhe-Leu-Asp-Val-d-Arg-d-Arg) (ZD7349) compatible with depot formulation (2000)

Additional structure-activity relationship studies on potent cyclic peptide inhibitors of very late antigen-4 (VLA-4) are reported. The new N- to C-terminal cyclic hexa-, hepta- and octapeptide inhibitors like cyclo(MeIle/MePhe-Leu-Asp-Val-X) (X = 2-4 amino acids containing hydrophobic and/or basic side chains) were synthesized using solid phase peptide synthesis methods. The peptides were evaluated in in vitro cell adhesion assays and in in vivo inflammation models. Many of the peptides like cyclo(MePhe-Leu-Asp-Val-D-Arg-D-Arg) (ZD7349) (17), cyclo(MeIle-Leu-Asp-Val-D-Arg-D-Arg-D-Phe) (20), cyclo(MeIle-Leu-Asp-Val-D-Arg-D-Arg-MePhe) (21) and cyclo(MePhe-Leu-Asp-Val-D-Arg-D-Arg-D-Ala-D-Ala) (23) were potent inhibitors of VLA-4-mediated cell adhesion and inhibited ovalbumin-induced delayed type hypersensitivity (DTH) response in mice. The more potent compounds were highly selective and did not affect U937 cell adhesion to fibronectin (VLA-5), phorbolmyristate acetate or PMA-differentiated U937 cell adhesion to intercellular cell adhesion molecule-1 (ICAM-1)-expressing Chinese hamster ovary cells (LFA-1) and adenosine diphosphate (ADP)-induced platelet aggregation (GPIIb/IIIa). In contrast to the inhibitors like Ac-cyclo(D-Lys-D-Ile-Leu-Asp-Val) and cyclo(CH2CO-Ile-Leu-Asp-Val-Pip-CH2CO-Ile-Leu-Asp-Val-Pip) described earlier, the new compounds were much more compatible with the depot formulations based on poly(DL-lactide-co-glycolide) polymers. The hexapeptide cyclo(MePhe-Leu-Asp-Val-D-Arg-D-Arg) (ZD7349) (17) inhibited MOLT-4 cell adhesion to fibronectin and vascular cell adhesion molecule-1 (VCAM-1) with IC50 values of 260 and 330 nM, respectively, and did not show any significant effect against other integrins (IC50 > 300 microM). ZD7349 inhibited ovalbumin-induced DTH response in mice when administered continuously using a mini-pump (ED50 0.01 mg/kg/day) or when given as an s.c. or i.v. bolus injection at a dose of 1-10 mg/kg. ZD7349 was also active in type II collagen-induced arthritis (CIA) and experimental autoimmune encephalomyelitis (EAE) tests at a dose of 3-10 mg/kg. The peptide was released from some formulations over a period of 10-20 days. ZD7349 is currently undergoing pre-clinical investigation.
Improved Lower Bounds on Signal Parameter Estimation (1975)

An improved technique for bounding the mean-square error of signal parameter estimates is presented. The resulting bounds are independent of the bias and stronger than previously known bounds.
Reusable, Polystyrene‐Resin‐Supported, Palladium‐Catalyzed, Atom‐Efficient Cross‐Coupling Reaction of Aryl Halides with Triarylbismuths (2009)

Abstract A rapid, atom‐efficient, cross‐coupling reaction of triarylbismuths with aryl bromides or aryl iodides was reported, and the reaction involves the use of a catalytic amount of polystyrene‐supported palladium in the presence of KF as base in DMSO at 105 °C in an open atmosphere. All three aryl groups of the triarylbismuths participated in the reaction and produced polyfunctional biaryls in excellent yields. The polymeric catalyst can be easily separated from the reaction mixture and reused more than 10 times without showing any obvious decrease in activity.
Antimicrobial Property of a Herbal Preparation Containing <i>Dalbergia Sissoo</i> and <i>Datura Stramonium with</i> Cow Urine against Pathogenic Bacteria (2008)

In this study, a herbal preparation containing Dalbergia sissoo and Datura stramoium with cow urine (DSDS), was evaluated for its antibacterial potential against pathogenic strains of gram-positive (Staphylococcus aureus and Streptococcus pneumoniae) and gram-negative (Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumoniae) bacteria. Antibacterial activity was compared to standard antibiotic drugs i.e. Chloramphenicol (30 mcg), Ampicillin (10 mcg), Nalidixic acid (10 mcg) and Rifampicin (30 mcg). Cow urine extract was found to be most active against both gram-positive as well as gram-negative bacteria. Clinical isolate of S. aureus showed higher sensitivity towards cow urine extract of DSDS than standard strains, and inhibited growth on most regulatory levels such as inhibition of protein, DNA, RNA and peptidoglycan synthesis. The results of the present study shows that the cow urine extract of DSDS may be used as a potent antiseptic preparation for prevention and treatment of chronic bacterial infections.
Gel Chromatographic Evidence for the Participation of the Higher Polymers in the Self-Association System of a Flavoenzyme D-Amino Acid Oxidase (1984)

The self-association of subunits of D-amino acid oxidase holoenzyme was studied by high-speed gel filtration with a short column of TSK-GEL G3000 SW in 0.1 M sodium pyrophosphate (pH 8.3) at 25 degrees C. Over the range of the peak concentrations of 0.009-4.45 mg/ml in the presence of FAD the apparent Stokes radii increased with an increase of the concentrations and did not level off. The largest value obtained in this study was 61.5 A. This would correspond to that calculated for the hexamer with linear subunit arrangement which has the largest Stokes radius among the various arrangements. These results provide the first gel chromatographic evidence that the higher polymers greater than the dimer participate in the self-associating system of the enzyme.
Molecular characterization of EGFR, PDGFRA and VEGFR2 in cervical adenosquamous carcinoma (2009)

This is the most extensive analysis of EGFR, PDGFRA and VEGFR2 in cervical adenosquamous carcinomas. Despite the absence of EGFR and PDGFRA activating mutations, the presence of overexpression of these three important therapeutic targets in a subset of cases may be important in predicting the sensitivity of adenosquamous carcinoma to specific anti-RTKs drugs.
Hazard Summary Report Experimental Breeder Reactor II (EBR-II) (1957)

From Forward: "This report describes the present conceptions of the Experimental Breeder Reactor-II as well as the safety procedures and precautions which are currently anticipated for its operation."
Automated Machine Learning with Monte-Carlo Tree Search (Extended Version). (2019)

The AutoML task consists of selecting the proper algorithm in a machine learning portfolio, and its hyperparameter values, in order to deliver the best performance on the dataset at hand. Mosaic, a Monte-Carlo tree search (MCTS) based approach, is presented to handle the AutoML hybrid structural and parametric expensive black-box optimization problem. Extensive empirical studies are conducted to independently assess and compare: i) the optimization processes based on Bayesian optimization or MCTS; ii) its warm-start initialization; iii) the ensembling of the solutions gathered along the search. Mosaic is assessed on the OpenML 100 benchmark and the Scikit-learn portfolio, with statistically significant gains over Auto-Sklearn, winner of former international AutoML challenges.
A space- and time-efficient Implementation of the Merkle Tree Traversal Algorithm (2014)

We present an algorithm for the Merkle tree traversal problem which combines the efficient space-time trade-off from the fractal Merkle tree [3] and the space efficiency from the improved log space-time Merkle trees traversal [8]. We give an exhaustive analysis of the space and time efficiency of our algorithm in function of the parameters H (the height of the Merkle tree) and h (h = H L where L is the number of levels in the Merkle tree). We also analyze the space impact when a continuous deterministic pseudo-random number generator (PRNG) is used to generate the leaves. We further program a low storage-space and a low time-overhead version of the algorithm in Java and measure its performance with respect to the two different implementations cited above. Our implementation uses the least space when a continuous PRNG is used for the leaf calculation.
Pulsed laser deposition and ferroelectric characterization of bismuth titanate films (1991)

Stoichiometric films of bismuth titanate, Bi4Ti3O12, have been grown for the first time by the technique of pulsed excimer laser deposition. Ferroelectric films were obtained at temperatures as low as 500 °C on Si(100), MgO(110), and Pt-coated Si(100) substrates. Hysteresis measurements using a Pt-coated Si sample yielded a saturation polarization value of about 28 μC/cm2, consistent with a randomly oriented titanate film structure. A preliminary metal-insulator-semiconductor sandwich structure of the form Bi4Ti3O12-CaF2(100 Å)-Si was grown and used to examine polarization induced memory switching effects.
Highly Efficient Photovoltaic Polymers Based on Benzodithiophene and Quinoxaline with Deeper HOMO Levels (2015)

We present the synthesis and photovoltaic application of four conjugated polymers composed of benzo[1,2-b:4,5-b′]dithiophene (BDT)-based and 2,3-diphenyl-5,8-di(thiophen-2-yl)quinoxaline (DTQx)-based units. Fluorination of the DTQx units and the conjugated side groups of the BDT unit shows synergistic effect on molecular energy level modulation of the polymers, and as a result, the polymer PBQ-4 exhibits the deepest HOMO and LUMO levels in these four polymers. The characterizations of the photovoltaic properties of the polymer solar cells (PSCs) based on these four polymers reveal that the fluorination has little influence on short-circuit current density (JSC) and fill factor (FF) but is very helpful to enhance open-circuit voltage (VOC) of the devices. Benefiting from the synergistic effect of the fluorination, the device based on PBQ-4 shows a high VOC of 0.90 V, which is 0.26 V higher than the polymer without fluorine and ca. 0.10 V higher than the other two polymers with less fluorine. As a result, a power conversion efficiency (PCE) of 8.55% was recorded in the PBQ-4 based device, which is much higher than those of the other three polymers and also the highest one for the BDT-Qx-based polymers.