gebhart/patrepeval huggingface dataset:
Analysis of Cellular Phosphoinositides and Phosphoinositols by Extraction and Simple Analytical Procedures (2003)

Part A. Biosynthesis and Extraction of Phosphoinositides and PhosphoinositolsThe minor inositol-containing membrane phospholipids, the phosphoinositides, play a central role in cell signal transduction. Activation of a hormone-sensitive phospholipase C (phosphoinositidase C) results in the rapid catabolism of the polyphosphoinositides to form the two second messengers inositol 1,4,5-trisphosphate (Ins(l,4,5)P3), a water soluble phosphoinositol that promotes the release of Ca2+ from intracellular stores, and diacylglycerol (DG), which remains in the plasma membrane and activates protein kinase C (, , ). See Fig. 1 for a summary of the pathways. Open image in new window Fig. 1. Metabolic pathways activated as a consequence of phosphoinositidase C action. In Panel A major metabolic pathways activated by phosphoinositidase C action on PtdIns(4,5)P2 are shown with solid arrows. Some of the additional pathways that may be activated are shown by broken arrows Abbreviations: Ptdlns: phosphatidylinositol; PtdIns4P. phosphatidylinositol 4-phosphate; PtdIns(4,5)P2 phosphatidylinositol 4,5-bisphosphate; DG: diacylglycerol; PtdOH: phosphatidic acid; CDP-DG: CDP-diacylglycerol; Ins: Inositol. For phosphoinositols, abbreviations are in the form Ins(x,y,z)Pn where x, y, and z refer to the positions of the phosphate groups on the myo-inositol ring and n refers to the total number of phosphates. Panel B is a simplified outline of the metabolic pathways in (A) to show alternative abbreviations. PI: phosphatidylinositol, PIP: phosphatidyl-inositol phosphate; PIP2, phosphatidylinositol bisphosphate; DG, PtdOH, CDP-DG and Ins as above. Phosphoinositols are referred to as IPn where n refers to the number of phosphates on the inositol ring In both panels, sites of Li*+ inhibition are also shown.
Duct Design of Vehicle Dual-unit Low-power Power Station (2012)

The power station is an important part of the vehicle system.With the development of the reliability and maneuverability of the system,the demand for low-power power station increases continuously.And the same platform is always needed to be shared by a power station and a system.A kind of ventilation and heat dissipation design of vehicle dual-unit low-power power station is introduced.Based on the structure design of inlet duct,the amount of heat dissipation calculation in a power station and the selection method of axial fans,the application tech nology basis of the low-power air-cooled power station which will equipped on vehicle system is provided.
Skin-interfaced systems for sweat collection and analytics (2018)

Recent interdisciplinary advances in materials, mechanics, and microsystem designs for biocompatible electronics, soft microfluidics, and electrochemical biosensors establish the foundations for emerging classes of thin, skin-interfaced platforms capable of capturing, storing, and performing quantitative, spatiotemporal measurements of sweat chemistry, instantaneous local sweat rate, and total sweat loss. This review summarizes scientific and technical progress in this area and highlights the implications in real time and ambulatory modes of deployment during physical activities across a broad range of contexts in clinical health, physiology research, fitness/wellness, and athletic performance.
Quantum mechanical simulation for ultra-thin high-k gate dielectrics metal oxide semiconductor field effect transistors (2004)

Abstract:- High-k dielectric materials are being considered as replacement for SiO2 as the gate dielectric while retaining the low equivalent oxide thickness (EOT) required next generation metal oxide semiconductor field effect transistors (MOSFETs). In this paper, we simulate the capacitance – voltage (C-V) of n-type MOSFET devices with different high-k dielectric insulator numerically. According to the results, high-k dielectric materials maintain the capacitance and provide a robust physical thickness preventing tunneling current. Quantum mechanism must be considered in the simulation or a 9.3 % overestimation of capacitance will be observed in an extreme case. Capacitance of high-k dielectrics couldn’t be estimated by capacitance of insulator with EOT directly because a 13 % difference is observed. To obtain an accurate result, a self-consistent Schrödinger – Poisson equation should be solved.
Notes on Other Actuarial Journals (1970)

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Growth Retardation of Inner Cell Mass Cells in Polyspermic Porcine Embryos Produced In Vitro1 (1999)

The in vitro viability of polyspermic pig eggs was investigated. Immature oocytes were matured and fertilized in vitro. Approximately 10 h after insemination, the eggs were centrifuged at 12 000 x g for 10 min and individually classified into two (2PN)- and poly-pronuclear (PPN, 3 or 4 pronuclei) eggs. The classified eggs were cultured in vitro or in vivo. Nuclei numbers of inner cell mass (ICM) and trophectoderm (TE) were compared between 2PN- and PPN-derived blastocysts. The frequency of development in vitro of 2PN and PPN eggs to the blastocyst stage was 53.6% and 40.7%, respectively. The mean number (8.2 +/- 0.7, n = 48) of ICM nuclei of 2PN-derived blastocysts was higher than that (4.2 +/- 0.8, n = 37) of PPN-derived blastocysts (p < 0.001), whereas there was no difference (p > 0.05) in mean numbers of total (46.7 +/- 3.4 vs. 39. 9 +/- 3.9) and TE nuclei (38.5 +/- 2.9 vs. 35.7 +/- 3.3) between the two groups. Development of 2PN and PPN eggs cultured in vivo to the blastocyst stage was 33.3% and 27.4%, respectively. The numbers of ICM and TE nuclei of these embryos cultured in vivo showed a pattern similar to that for the in vitro-produced blastocysts. Additionally, fetuses were obtained on Day 21 from both the 2PN and the PPN groups. This suggests that polyspermic pig embryos develop to the blastocyst stage and beyond, although showing a smaller ICM cell number as compared to normal embryos.
Plasma-enhanced-chemical-vapor-deposited ultralow k for a postintegration porogen removal approach (2006)

Conventional Cu-ultra low K (ULK) integration schemes lead to a drastic increase of the effective dielectric constant due to porous material degradation during process steps. Although a postintegration porogen removal scheme allows overcoming these issues, only spin-on dielectrics were developed to validate this approach. In this letter, plasma-enhanced chemical-vapor deposition is used to deposit ULK dielectric (k&lt;2.5). The precursor chemistry and the deposition conditions have been chosen to obtain a material with the required characteristics to use a postintegration porogen removal approach: porogen thermal stability up to 325°C, good mechanical properties of the hybrid film, no metallic barrier diffusion in the film, and a minimal shrinkage after the porogen removal treatment.
Figueiredo Pimentel e o romance O aborto (1893): uma história pouco conhecida do naturalismo no Brasil (2015)

Nas décadas de 1890 a 1910, Figueiredo Pimentel (1869–1914) era conhecido como um dos escritores e jornalistas mais produtivos do Rio de Janeiro. Assim como outros homens de letras de sua geração, como Coelho Neto (1864–1934) e Olavo Bilac (1865–1918), Figueiredo Pimentel foi um polígrafo que produziu uma extensa quantidade de obras, em variados gêneros textuais: conto, poesia, crônica, teatro, folhetim, romance e literatura infantil, desempenhando várias facetas literárias em sua trajetória. Dessas facetas, duas foram parcialmente estudadas pela historiografia: a de cronista da coluna ‘O Binóculo’ da Gazeta de Notícias do Rio de Janeiro , que debatia os costumes cariocas na Belle Époque , e a de autor bem sucedido do gênero de literatura infanto-juvenil. Na sua trajetória há uma faceta que permanece pouco conhecida: o Figueiredo Pimentel autor de romances naturalistas, com que estreou na vida literária em 1893, com grande escândalo, ao lançar o romance O aborto , publicado pela Livraria do Povo . Interessado na faceta naturalista do escritor, este artigo tem como objetivo apresentar um breve estudo sobre a trajetória de Figueiredo Pimentel como romancista naturalista, a partir da história da escrita, publicação e recepção do primeiro romance naturalista do autor, um best-seller que foi considerado pela crítica da época como uma obra pornográfica.
Electric field induced semiconductor-to-metal phase transition in vertical MoTe2 and Mo1-xWxTe2 devices (2017)

Over the past years, transition metal dichalcogenides (TMDs) have attracted attention as potential building blocks for various electronic applications due to their atomically thin nature. An exciting development is the recent success in 'engineering' crystal phases of TMD compounds during the growth due to their polymorphic character. Here, we report an electric field induced reversible engineered phase transition in vertical 2H-MoTe2 devices, a crucial experimental finding that enables electrical phase switching for these ultra-thin layered materials. Scanning tunneling microscopy (STM) was utilized to analyze the TMD crystalline structure after applying an electric field, and scanning tunneling spectroscopy (STS) was employed to map a semiconductor-to-metal phase transition on the nanoscale. In addition, direct confirmation of a phase transition from 2H semiconductor to a distorted 2H' metallic phase was obtained by scanning transmission electron microscopy (STEM). MoTe2 and Mo1-xWxTe2 alloy based vertical resistive random access memory (RRAM) cells were fabricated to demonstrate clear reproducible and controlled switching with programming voltages that are tunable by the layer thickness and that show a distinctly different trend for the binary compound if compared to the ternary materials.
Spacer Removal Technique for Boosting Strain in n-Channel FinFETs With Silicon-Carbon Source and Drain Stressors (2008)

A novel and low-cost spacer removal technique proved successful in further enhancing the I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Dsat</sub> performance of already strained n-channel trigate FinFETs with SiC source and drain (S/D) stressors. This extra enhancement is attributed to increased longitudinal tensile channel stress as a result of increased stress coupling efficiency from the SiC S/D stressors to the channel. The electrical results also establish that this extra enhancement will become even more significant as physical gate lengths are scaled down.
<i>Escherichia coli</i>and Community-acquired Gastroenteritis, Melbourne, Australia (2004)

As part of a study to determine the effects of water filtration on the incidence of community-acquired gastroenteritis in Melbourne, Australia, we examined fecal samples from patients with gastroenteritis and asymptomatic persons for diarrheagenic strains of Escherichia coli. Atypical strains of enteropathogenic E. coli (EPEC) were the most frequently identified pathogens of all bacterial, viral, and parasitic agents in patients with gastroenteritis. Moreover, atypical EPEC were more common in patients with gastroenteritis (89 [12.8%] of 696) than in asymptomatic persons (11 [2.3%] of 489, p < 0.0001). Twenty-two random isolates of atypical EPEC that were characterized further showed marked heterogeneity in terms of serotype, genetic subtype, and carriage of virulence-associated determinants. Apart from the surface protein, intimin, no virulence determinant or phenotype was uniformly present in atypical EPEC strains. This study shows that atypical EPEC are an important cause of gastroenteritis in Melbourne.
Synthesis of 3-Phospholenes by Reduction of Diene—Phosphonous Dichloride Adducts<sup>1</sup> (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of 3-Phospholenes by Reduction of Diene—Phosphonous Dichloride Adducts1Louis D. Quin and David A. MathewesCite this: J. Org. Chem. 1964, 29, 4, 836–839Publication Date (Print):April 1, 1964Publication History Published online1 May 2002Published inissue 1 April 1964https://pubs.acs.org/doi/10.1021/jo01027a016https://doi.org/10.1021/jo01027a016research-articleACS PublicationsRequest reuse permissionsArticle Views162Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Deamidation Alters the Structure and Decreases the Stability of Human Lens βΑ3-Crystallin (2007)

According to the World Health Organization, cataracts account for half of the blindness in the world, with the majority occurring in developing countries. A cataract is a clouding of the lens of the eye due to light scattering of precipitated lens proteins or aberrant cellular debris. The major proteins in the lens are crystallins, and they are extensively deamidated during aging and cataracts. Deamidation has been detected at the domain and monomer interfaces of several crystallins during aging. The purpose of this study was to determine the effects of two potential deamidation sites at the predicted interface of the betaA3-crystallin dimer on its structure and stability. The glutamine residues at the reported in vivo deamidation sites of Q180 in the C-terminal domain and at the homologous site Q85 in the N-terminal domain were substituted with glutamic acid residues by site-directed mutagenesis. Far-UV and near-UV circular dichroism spectroscopy indicated that there were subtle differences in the secondary structure and more notable differences in the tertiary structure of the mutant proteins compared to that of the wild type betaA3-crystallin. The Q85E/Q180E mutant also was more susceptible to enzymatic digestion, suggesting increased solvent accessibility. These structural changes in the deamidated mutants led to decreased stability during unfolding in urea and increased precipitation during heat denaturation. When simulating deamidation at both residues, there was a further decrease in stability and loss of cooperativity. However, multiangle-light scattering and quasi-elastic light scattering experiments showed that dimer formation was not disrupted, nor did higher-order oligomers form. These results suggest that introducing charges at the predicted domain interface in the betaA3 homodimer may contribute to the insolubilization of lens crystallins or favor other, more stable, crystallin subunit interactions.
AC losses in high T/sub c/ superconductors (1995)

The losses in high T/sub c/ superconductors do not differ in principle from those in low T/sub c/ materials, and the same calculations can be used. However it is necessary to allow for the granularity of the materials and the high aspect ratio of the conductors. This paper derives simple, if approximate, expressions for calculating the losses in the most important cases for practical purposes. These are the use of BSCCO tapes in magnets and cables at power frequencies. The predictions of elliptical and thin strip models are compared and it is found that an elliptical geometry agrees best with the experimental results. It is also found that the voltage measured in a transport measurement depends on the position of the contacts and that if an unambiguous loss measurement is required it is necessary to include the flux outside the sample in the voltage measurement loop.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Synthesis of PHI (peptide histidine isoleucine) and related peptides and immunochemical confirmation of amino acid residue in position 24 of PHI with use of the synthetic peptides (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of PHI (peptide histidine isoleucine) and related peptides and immunochemical confirmation of amino acid residue in position 24 of PHI with use of the synthetic peptidesK. Nokihara, C. Yanaihara, K. Iguchi, S. Fukata, H. Akai, M. Tanaka, T. Mochizuki, K. Tatemoto, V. Mutt, and N. YanaiharaCite this: J. Am. Chem. Soc. 1984, 106, 25, 7909–7916Publication Date (Print):December 1, 1984Publication History Published online1 May 2002Published inissue 1 December 1984https://pubs.acs.org/doi/10.1021/ja00337a046https://doi.org/10.1021/ja00337a046research-articleACS PublicationsRequest reuse permissionsArticle Views147Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Multi-rate encoding for HEVC-based adaptive HTTP streaming with multiple resolutions (2015)

Adaptive HTTP streaming requires a video to be encoded at different rates and qualities called representations. The encoding of multiple representations with the new video coding standard HEVC is computationally complex. In this paper, we propose a multi-rate encoding method which reduces the complexity of encoding a video at multiple spatial resolutions. We first examine block structure similarities at different resolutions and propose a method to derive the block structure for a low resolution representation from a reference high resolution encoding. The derived block structure is used to speed up the encoding of low resolution representations. We further consider the content of the videos in order to achieve a rate-distortion (RD) performance similar to independent HEVC encoding. Experimental results show that the encoding time can be reduced by 50% on average for a low resolution video without degrading the RD performance.
Hyperbranched polysiloxane (HBPSi)-based polyimide films with ultralow dielectric permittivity, desirable mechanical and thermal properties (2016)

A 35 wt% HBPSi polyimide film exhibits an ultralow dielectric permittivity (2.24), accompanied by the most desirable comprehensive properties.
Haemodynamic and renal effects of urodilatin bolus injections in patients with congestive heart failure (1992)

Urodilatin (ANF(95-126)) is an analogue of the atrial natriuretic factor (ANF(99-126)), which has been isolated from human urine. Recently we have shown in healthy volunteers, that intravenous bolus injections of synthetic urodilatin produce more pronounced reductions of pulmonary arterial pressure than ANF(99-126). To compare haemodynamic and renal effects of synthetic urodilatin with those of ANF(99-126) in congestive heart failure (CHF), 12 patients (66.3 +/- 1.4 years) received either two high dose intravenous bolus injections of 4 micrograms kg-1 bw Urodilatin (URO) at a 30 min interval (n = 6) or the same doses of ANF(99-126) (n = 6). Prior to i.v. URO, no URO immunoreactivity was found in human plasma (specific RIA, no crossreactivity to ANF). Similar to ANF, the increase in diuresis (1.4 +/- 0.7 to 3.7 +/- 1.6 ml min-1) and natriuresis (169 +/- 114 to 430 +/- 197 mumol min-1) was moderate after URO in CHF. During the 90 min study period, mean plasma cyclic GMP levels increased much more after URO (by 53.4 +/- 15.1 nM) than after ANF (by 13.1 +/- 3.0 nM; P = 0.04). In contrast to ANF, i.v. bolus injections of URO produced sustained haemodynamic effects in CHF lasting up to 90 min: The average (0-90 min) reduction of systemic vascular resistance was more pronounced after URO (-578 +/- 148) than after ANF (-204 +/- 65 dyn*s*cm-5, P = 0.04).(ABSTRACT TRUNCATED AT 250 WORDS)
A Ligand-Binding Assay for Thyroxine-Binding Globulin Based on Polyethylene Glycol Separation (1982)

A simple ligand-binding assay for thyroxine-binding globulin (TBG) is described. The method depends on the partition of labelled thyroxine between bovine serum albumin and TBG. Differentiation between labelled thyroxine bound to TBG and bovine serum albumin is achieved by the addition of excess TBG antiserum and subsequent precipitation with polyethylene glycol. The results are compared with the Corning Immophase kit method for TBG.
Regulation of <i>Em</i> Gene Expression in Rice (1992)

Expression of the Em gene was characterized in rice (Oryza sativa L.) suspension cultures following exposure of the cultures to various combinations of abscisic acid (ABA) and salt. Response-saturating concentrations of either ABA (50 micromolar) or NaCl (0.4 molar) rapidly induced (by 60 minutes) the accumulation of Em mRNA, with a maximum accumulation occurring 12 to 24 hours after treatment. NaCl-induced Em expression was accompanied by a doubling of endogenous ABA levels as determined by immunoassay. Inhibition of ABA biosynthesis by fluridone during NaCl treatment reduced the levels of endogenous ABA by fourfold and Em expression by 50%. Desiccation of the cultures to 12 to 15% of their initial fresh weight increased endogenous ABA more than twofold and was accompanied by an increase in Em mRNA levels. Exposure of the cultures to heat shock temperatures, chilling, or ultraviolet light neither increased endogenous ABA levels nor induced Em expression. When a subthreshold or saturating level of NaCl was added in combination with increasing levels of ABA, Em transcripts were detected at ABA concentrations that alone did not induce expression of Em. Treatment with saturating levels of both NaCl and ABA resulted in a doubling of Em transcript levels over the maximum signal for each treatment alone. Hence, our data suggested that salt interacted synergistically with ABA, in part because of the increased sensitivity of rice cells to ABA. The effect of salt stress on Em gene expression in rice suspension cells appeared to operate through two pathways: one is mediated through increases in the level of ABA; the other is via a unique salt response pathway that includes an intermediate that is common to both the salt and ABA response chains.