gebhart/patrepeval huggingface dataset:
ULTRASTRUCTURAL STUDIES ON THE LYMPHATIC ANCHORING FILAMENTS (1968)

The fine structure of the lymphatic capillary and the surrounding tissue areas was investigated. Instead of a continuous basal lamina (basement membrane) surrounding the capillary wall, these observations revealed the occurrence of numerous fine filaments that insert on the outer leaflet of the trilaminar unit membrane of the lymphatic endothelium. These filaments appear as individual units, or they are aggregated into bundles that are disposed parallel to the long axis of the lymphatic capillary wall and extend for long distances into the adjoining connective tissue area among the collagen fibers and connective tissue cells. The filaments measure about 100 A in width and have a hollow profile. They exhibit an irregular beaded pattern along their long axis and are densely stained with uranyl and lead. These filaments are similar to the microfibrils of the extracellular space and the filaments observed in the peripheral mantle of the elastic fibers. Infrequently, connections between these various elements are observed, suggesting that the lymphatic anchoring filaments may also contribute to the filamentous units of the extracellular space. It is suggested that these lymphatic anchoring filaments connect the small lymphatics to the surrounding tissues and represent the binding mechansim that is responsible for maintaining the firm attachment of the lymphatic capillary wall to the adjoining collagen fibers and cells of the connective tissue area.
Homodyne detection in spectral phase interferometry for direct electric-field reconstruction (2001)

We study and demonstrate a version of spectral phase interferometry for direct electric-field reconstruction (SPIDER) that uses self-referencing homodyne detection. This technique has a higher sensitivity than conventional SPIDER, is self-calibrating, and can be adjusted for a wider range of pulse parameters.
Development of an Automated System for the Rapid Detection of Drilling Anomalies using Standpipe and Discharge Pressure (2011)

Abstract The requirements for the early detection and the control of kicks, losses and other anomalous conditions while drilling are becoming increasingly important as the industry drills in more challenging environments both onshore and offshore due to greater challenges with respect to equipment stresses and pressure regimes. This paper will present the design and testing of a high fidelity and high certainty system for the early identification of anomalous conditions while drilling such as kicks, losses, washouts, drill string plugging and hole bridging without the need for traditional delta flow equipment and interpretation methods. An explanation of how the system minimizes false alarms and how visual and audible methods inform the operator of the different anomalies as they are detected will be included. Installation of the equipment on the rig will also be presented and compared to current delta flow methods both for managed pressure drilling operations and conventional drilling operations. Maintenance and reliability issues will also be discussed. Full scale testing and tests using collected field data will be presented to demonstrate the system operation. Further development and field testing will also be discussed.
'Redskins' marks cancelled: offensive to Native Americans (2014)

The US Patent & Trademark Office's Trademark Trial and Appeal Board (TTAB) cancelled six registrations of trade marks incorporating the word ‘Redskins’, used by the Washington Redskins football team. While the team is not barred from using the marks, it will be denied legal recourse under trade mark law in cases of infringement, depriving the marks of much of their commercial value.
Editorial Vol.3(1) (2013)

DOI: http://dx.doi.org/10.4038/cjo.v3i1.5209Ceylon Journal of Otolaryngology Vol.3(1) 2013
COG: A particle transport code designed to solve the Boltzmann equation for deep-penetration (shielding) problems: Volume 1: User's Manual (1989)

COG is a Monte Carlo computer code designed to solve the Boltzmann equation for transporting neutrons and photons and, in future versions, charged particles. The techniques included in the code make it most suited for solving deep penetration (shielding) problems, but provision is also included for solving criticality problems. The current versions of COG run on Cray-1 and Cray/X-MP computers. We expect that future versions of the code will function on other machines but will still require substantially the same inputs described in this manual.
The World Wide Web Complete Reference (1995)

Part 1 An introduction to the Web: what is the World Wide Web how to use this book getting connected using Web browsers turnkey access packages Web access through information services. Part 2 Creating Web pages: the phenomena of the home page the philosophy of a good Web page the language of the Web - HTML HTML editors linking and embedding integrating other Internet services creating a data entry form finding a home for your pages securing your pages and forms gathering statistics with your Web pages. Part 3 Advance connection to the Internet: establishing your presence on the Web protocols and alphabet soup digital connections taking care of formalities. Part 4 Business opportunities with the Web: selling Internet access creating HTML documents for money boarding Web pages on your system. Part 5 Interesting uses for the Web: Internet publishing other fun on the Web.
Magnetic Separation of Melanoma-Specific Cytotoxic T Lymphocytes from a Vaccinated Melanoma Patient’s Blood Using MHC/Peptide Complex-Conjugated Bacterial Magnetic Particles (2009)

Target antigen-specific cytotoxic T lymphocytes (CTLs) play a key role in anticancer and antivirus immunity in the body, and purification of CTLs from heterogeneous immune cells is desired for an efficient cancer immunotherapy and fundamental research. Herein, a novel magnetic nanoparticle conjugated with major histocompatibility complex (MHC)/peptide complexes was developed for the magnetic separation of melanoma-specific CTLs. To conjugate biotinylated MHC/peptide complexes on nanosized bacterial magnetic particles (BacMPs), which were synthesized intracellularly by magnetotactic bacteria, phased modification of biotin and streptavidin onto BacMPs was investigated. When biotin was modified on BacMPs, a polyethylene oxide (PEO)-linker contributed to the maintenance of the high dispersion properties of BacMPs. Furthermore, nonspecific binding of BacMPs to cell surface was prevented by controlling the level of streptavidin bound on BacMPs and through PEO blocking of the empty streptavidin sites on BacMPs. Finally, single-step magnetic separation of melanoma-specific CTLs was demonstrated using developed MHC/MAGE-1 A24 peptide complex-conjugated BacMPs. Melanoma-reactive cells and melanoma-specific CTLs were successfully separated from stimulated peripheral blood mononuclear cells derived from a vaccinated melanoma patient with 93.1% and 87.7% purity, respectively, and specificity of antigen recognition and cytokine secretion from separated CTLs were confirmed. The potential of MHC/peptide complex-conjugated BacMPs was indicated for efficient separation of antigen-specific CTLs in cancer immunotherapy and fundamental research.
Treatment of Bowen's disease with topical dinitrochlorobenzene and 5-fluorouracil (1976)

"Bowen's disease" is a clinical and histologic diagnosis describing the lesions (single or multiple) of cutaneous in situ squamous cell carcinoma. The case of a 54-year-old man with 60 such intra-epidermal carcinomas, and a history of arsenic ingestion, is presented. The patient was sensitized to dinitrochlorobenzene (DNCB), and his lesions were treated with a topical DNCB preparation. All lesions disappeared completely (demonstrated by biopsy of several sites) except for a large (12 X 7 cm) tumor on the flank which partially resolved. Total regression of this lesion was achieved by adding topical 5-fluorouracil (5-FU) therapy. This case demonstrates that the inflammatory reaction induced by DNCB (as evidenced by erythema and by a dense inflammatory cell infiltrate in biopsied areas of treated lesions) can lead to regression of extensive in situ epidermoid carcinoma, and that combined therapy with DNCB and 5-FU can be more effective than DNCB alone. Both agents in appropriate concentrations led to selective destruction of neoplastic tissue with no effect on adjacent normal skin. No systemic toxicity was observed.
Gold-Colored Organic Crystals of an Azobenzene Derivative (2014)

A new azobenzene derivative, bis[4-(3-methylbutoxy)phenyl]diazene (DC-azo), was synthesized as yellow powder through a three-step reaction. DC-azo was crystallized from a mixture of acetone/water in the form of highly insulating gold-colored crystals with a specular reflectance of 21% over the wavelength range of 520-800 nm. The CIELAB color space of the crystals indicated that the crystals were slightly more reddish and less yellowish than metallic Au. The crystals retained their gold coloration under dry conditions and were stable up to 383 K. The X-ray diffraction (XRD) measurements estimated the long-range periodical thickness in the crystal to be 1.12 nm, thereby indicating that the DC-azo molecules were oriented such that the azobenzene moieties showed a tilt angle of 32.2° against the crystal surface. The gold-colored crystals of DC-azo could be a potential substitute for the conventional metallic paints.
Reduction of glutathione S-transferase P-form mRNA expression in remodeling nodules in rat liver revealed by in situ hybridization (1997)

Glutathione S-transferase P-form (GST-P) mRNA levels and distribution were sequentially analyzed by in situ hybridization histochemistry (ISH) in rat livers during and after induction of preneoplastic foci and nodules in the Solt-Farber model. Dot blot analysis showed GST-P transcripts in the liver to be elevated coincidental with the development of GST-P-positive lesions. GST-P ISH indicated that the majority of early foci and some of the resultant lesions showed uniformly high levels of GST-P mRNA. However, the majority of foci and nodules after completion of the selection regimen exhibited a progressive loss of staining for GST-P mRNA. Similar results were obtained for gamma-glutamyltransferase (GGT) transcripts, indicating that phenotypic reversion is controlled by factors operating at the level of gene expression in both cases. Expression of GST-P mRNA was high in all hepatocellular carcinoma samples, whereas the levels of GGT transcripts varied considerably, so that the two enzymes showed a degree of independence in their regulation. The present data for transcription suggest that GST-P is a stable marker of preneoplastic and neoplastic cells, not only at the protein but also at the mRNA level, throughout hepatocarcinogenesis in the rat. The reason why transcription of GST-P mRNA is switched off as part of the reversion to a normal organization remains to be elucidated.
SMART POLYMERS: INNOVATIONS IN NOVEL DRUG DELIVERY (2011)

Smart polymers are attracting the researchers for development of novel drug delivery systems. Importance of smart polymers is rising day by day as these polymers undergo large reversible, physical or chemical changes in response to small changes in the environmental conditions such as pH, temperature, dual- stimuli, light and phase transition. Smart polymers are representing promising means for targeted drug delivery, enhanced drug delivery, gene therapy, actuator stimuli and protein folders. In the present paper, different types of smart polymers, along with their examples, mechanism of action and applications are reviewed.
Nutrition and Feeding of Fish and Crustaceans (2001)

Nutrition and feeding of fish and crustaceans / , Nutrition and feeding of fish and crustaceans / , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی
Designing with FPGAs and CPLDs (1994)

This text covers the entire field of FPGAs and is intended to bring designers and engineers up to speed in this area. It describes all products within a comparative framework that highlights the strengths and weaknesses of individual FPGAs and their application potential.
Modified Landweber algorithm for robust particle sizing by using Fraunhofer diffraction (2014)

In this paper, a robust modified Landweber algorithm was proposed to retrieve the particle size distributions from Fraunhofer diffraction. Three typical particle size distributions, i.e., Rosin-Rammler, lognormal, and bimodal normal distributions for particles ranging from 4.8 to 96 μm, were employed to verify the performance of the algorithm. To show its merits, the proposed algorithm was compared with the Tikhonov regularization algorithm and the ℓ1-norm-based algorithm. Simulation results showed that, for noise-free data, both the modified Landweber algorithm and the ℓ1-norm-based algorithm were better than the Tikhonov regularization algorithm in terms of accuracy. When the data was noise-contaminated, the modified Landweber algorithm was superior to the other two algorithms in both accuracy and speed. An experimental setup was also established and the results validated the feasibility and effectiveness of the proposed method.
Specificity of a High-Sensitivity Cardiac Troponin I Assay Using Single-Molecule–Counting Technology (2008)

Cardiac troponin is the standard for diagnosis or exclusion of acute myocardial infarction. Recent guidelines recommend a cutoff value at the upper 99th percentile (99th%)1 of values for a reference population of healthy individuals and assay imprecision (CV) ≤10% at this cutoff (1). Many commercial assays cannot meet these criteria, and values below the 99th% cutoff appear to supply diagnostic and prognostic information (2)(3). Recently the Erenna™ cardiac troponin I (cTnI) immunoassay (Singulex) has been shown to provide sensitivity and precision that meet these goals (4), with a preliminary 99th% cutoff value at 8 ng/L and 10% CV of 1.8 ng/L (5). This novel assay uses single-molecule counting technology and has been previously described. However, we could not fully exclude the possibility that, with such sensitive limits of detection, low-level nonspecific binding (NSB) events might contribute to cTnI measurements. We explored this issue by testing potential sources of NSB events.

To test for NSB of serum or plasma constituents, cTnI was quantified in 4 specimen types from 20 healthy individuals, serum, EDTA, lithium heparin, and sodium-citrated plasma. The protocol was approved by the University of California Committee on Human Research. All 20 individuals were free of cardiac disease or symptoms (13 female, 7 male, mean age 43 years, …
Stress Corrosion Cracking of 72/28 Brass in Sodium Chlorate Solution (1982)

Sodium chlorate solution was tested at ambient temperature as a stress corrosion cracking (SCC) medium for 72/28 brass. The constant strain rate technique was used and a rate of 1.5 × 10−5sec−1 was applied. The effect of concentration and applied potential on the SCC susceptibility was investigated. The results indicated that in 1.0 and 0.1 M NaClO3 solutions, the alloy was susceptible to SCC under open-circuit conditions and at applied anodic potentials, but not at applied cathodic potentials. In 0.01 M solution, an overpotential of 125 mV was required for cracking to take place while no SCC was observed at concentrations ≤ 0.005 M. The exposed surfaces of the specimens were covered by reddish-brown film when they were anodically polarized while the fracture surfaces were film-free. The crack morphology was mainly integranular at and near the open-circuit potential while it was predominantly transgranular under anodic polarization. Metallographic inspection revealed the formation of discontinuous dezincified layer for stressed specimens in relatively concentrated solutions which was more obvious under applied anodic potentials.
P/Q Ca<sup>2+</sup> channel blockade stops spreading depression and related pyramidal neuronal Ca<sup>2+</sup> rise in hippocampal organ culture (2003)

Ca2+ channels and pyramidal cell Ca2+ are involved in hippocampal spreading depression (SD), but their roles remain elusive. Accordingly, we characterized Ca2+ changes during SD in CA3 pyramidal neurons and determined whether Ca2+ channel antagonists could prevent SD. SD was induced in hippocampal organotypic cultures (HOTCs), in which experimental conditions can be rigorously controlled. SD was triggered by transient exposure to sodium acetate (NaAc)-based Ringer's coupled to an electrical pulse in the dentate gyrus and its occurrence confirmed with interstitial DC recordings. Pyramidal cell Ca2+ was measured with fura-2 filled cells and was quantified at the soma, proximal and more distal apical dendrites. Regional Ca2+ changes began simultaneously with the triggering pulse of SD and reached three distinct peaks before returning to baseline concomitant with the interstitial DC potential of SD. The first peak occurred within 5 s of the triggering pulse, was smallest, and heralded the onset of SD. The second Ca2+ change was the greatest and reached a peak 6 s later, during the early phase of SD. The third was intermediate in size and occurred 18 s later, as SD reached its maximum interstitial DC change. SD was prevented by nonselective Ca2+ blockade (Ni2+ and Cd2+) but not by either L-Ca2+ channel (nifedipine) or N-Ca2+ channel inhibition (omega-conotoxin GVIA). Importantly, SD was blocked by P/Q Ca2+ channel antagonism (omega-agatoxin-IVA), which also prompted a significant reduction in pyramidal cell Ca2+ change and hyperexcitability. These results show that the spatiotemporal pattern of pyramidal cell Ca2+ change with SD is multiphasic; they provide further evidence that these changes begin before electrophysiologic evidence of SD. Furthermore, they show that P/Q Ca2+ channel antagonism can prevent SD in HOTCs and it appears to do so by preventing the NaAc-induced increased pyramidal cell excitability from NaAc exposure, which may involve altered GABAergic transmission.
Interferons in the Therapy of Solid Tumors (1994)

Interferons, a group of naturally occurring proteins, possess potent immunological effects. The availability of large amounts of purified interferon through recombinant DNA technology has led to the testing of these agents against a number of tumor types. Interferon-alpha has been the most widely studied. The most encouraging results have been observed in the treatment of melanoma among nonhematological neoplasms, and in the locoregional treatment of other tumor types. It is hoped that further research into the use of the interferons, both singly and in combination with chemotherapy and other immunological agents, will lead to a better elucidation of their therapeutic role against cancer. In this article, the use of interferons in the treatment of solid tumors is reviewed.
Flexible User Profile Management for Context-Aware Ubiquitous Environments (2010)

With the important advent of multimedia services and the ubiquity of computing environments, the concept of context-awareness in services access and provisioning is getting crucial. Services, especially the multimedia ones, must perform automatically actions/operations to adapt the delivered content to the user expectations and his environment capabilities, thus ensuring the best quality of experience. To facilitate the adaptation process, we introduce a flexible context-sensitive user profile model that gathers static and dynamic data characterizing the user and his operational context. An efficient framework for managing and delivering the user profile is also proposed. A context-dependent user profile instance is created for each application according to its adaptation process needs. This paper also presents some implementation issues of the developed prototype together with an IPTV streaming use case.
Chronic Lymphocytic Leukemia B Cells Can Express CD40 Ligand and Demonstrate T-Cell Type Costimulatory Capacity (1998)

Chronic lymphocytic leukemia (CLL) is characterized by a clonal expansion of CD5(+) B cells in the peripheral blood. Associated immune aberrations include abnormal Th-cell function and pathogenic autoantibodies. Under most circumstances, CLL B cells do not proliferate in culture and express a limited repertoire of surface antigens, including CD19, CD20, CD23, CD27, CD40, and CD70. In this report, we demonstrate that freshly isolated B cells from a subset of CLL cases constitutively express CD40 ligand (CD40L, CD154), a member of the tumor necrosis factor family which is normally expressed by activated CD4(+) T cells and mediates T-cell-dependent B-cell proliferation and antibody production. The degree of CD40L expression varied considerably among the CLL cases examined. CD40L was detected in purified CLL B cells by immunofluorescence flow cytometry, by RT-PCR, and by immunoprecipitation. To demonstrate that CD40L in the CLL B cells is functional, we used irradiated CLL cells to stimulate IgG production by target, nonmalignant B cells in coculture. The CLL B cells induced IgG production by normal B cells to a similar degree as did purified T cells in a process which was partially inhibited by monoclonal antibody to CD40L. This is one of the first reports of CD40L expression in a B-cell tumor. The data suggest that CD40L in the tumor cells may be a factor in the generation of pathologic antibodies by normal B cells in some patients with CLL.
Antibody-Mediated Bacteriorhodopsin Orientation for Molecular Device Architectures (1994)

A rational method for constructing highly oriented films of purple membrane (PM) has been established by using two kinds of bispecific antibodies with different antigen-binding sites, one binding to a specific side of bacteriorhodopsin and the other to a phospholipid hapten. A hapten monolayer deposited on a metal electrode was treated with a bispecific antibody solution and incubated with a PM suspension to produce a highly oriented PM film, as confirmed by electron microscopy in which an immunogold labeling technique was used. This antibody-mediated PM monolayer was then used in the construction of a light-sensing photoelectric device. A comparison of the two incorporated PM monolayers showed that highly efficient photocurrents were produced by the PM monolayer whose unidirectionally oriented cytoplasmic surface faces the electrode.
Relationship between female ages and the theory of five tones correlated with five zang viscera in Huangdi Neijing (2006)

The results of higher frequency of Jiao tone in females is in accordance with the theory put forward by Ye Gui (a famous doctor in Qing Dynasty of China) that the liver is the congenital base of female life. In traditional Chinese medicine, Jiao tone is correlated with the liver, and Zhi tone is correlated with the heart. The high frequency of Zhi tone in younger females implies that regulating the Small Intestine Meridian of Hand-Taiyang and Heart Meridian of Hand-Shaoyin may be beneficial to the health maintenance of younger female.