gebhart/patrepeval huggingface dataset:
Parsing apical oxalate exchange in Caco-2BBe1 monolayers: siRNA knockdown of SLC26A6 reveals the role and properties of PAT-1 (2009)

The purpose of this investigation was to quantitate the contribution of the anion exchanger PAT-1 (putative anion transporter-1), encoded by SLC26A6, to oxalate transport in a model intestinal epithelium and to discern some characteristics of this exchanger expressed in its native environment. Control (Con) Caco-2 BBe1 monolayers, 6-8 days postseeding, were compared with those transfected with a small interfering RNA targeted to SLC26A6 (A6KD). Radiotracer and Ussing chamber techniques were used to determine the transepithelial unidirectional fluxes of Ox(2-), Cl(-), and SO(4)(2-) whereas fluorometric/BCECF measurements of intracellular pH were used to assess HCO(3)(-) exchange. PAT-1 was functionally targeted to the apical membrane, and SLC26A6 knockdown reduced PAT-1 protein (>60%) and mRNA (>75%) expression in A6KD. No net flux of Ox(2-), Cl(-), or SO(4)(2-) was detected in Con or A6KD monolayers, yet the unidirectional fluxes in A6KD were reduced 50, 35, and 15%, respectively. Cl(-)-dependent HCO(3)(-) efflux from A6KD was reduced 50% compared with Con. The difference between Con and A6KD properties represents that mediated solely by PAT-1, and by this approach we found that PAT-1-mediated oxalate influx and efflux are inhibited equally by mucosal DIDS (EC(50) approximately 5 microM) and that mucosal Cl(-) inhibits oxalate uptake with an EC(50) < 20 mM. Transepithelial Cl(-) gradients supported large, DIDS-sensitive net absorptive or secretory fluxes of oxalate in a direction opposite that of the imposed Cl(-) gradient. The overall symmetry of PAT-1-mediated oxalate exchange suggests that vectorial oxalate transport observed in vivo is principally dependent on the magnitude and direction of counterion gradients.
Planning for patient privacy and hospitability: a must do in oncology care. (2003)

The number one design challenge in the healthcare environment is the patient room. This space is one of the primary functional areas impacting hospital design and, quite often, the place of greatest controversy. This controversy is due to the length of time the patient spends in the room (compared to other areas), the amount of overall space required and the time dedicated to patient room utilization, maintenance, general arrangement and overall efficiency. In addition, there is a growing list of room types to be considered, many are of the ambulatory care, short stay and observation category. Other room types beyond the routine medical/surgical room include Intensive Care, Coronary Care, Surgical Intensive Care, Skilled Nursing, Rehabilitation and Oncology Care as well as more intensive Bone Marrow Transplantation, for example. Major features of the traditional acute care patient room require the space to be flexible, convertible, expandable and, most importantly, hospitable. For many, many years the patient room was considered a shared space with multiple beds and multiple users. The term semi-private has been used to describe the traditional two-bed and, sometimes 4-bed patient room. This article will address the programmatic elements of an inpatient area, the room and its functional components along with some examples for comparative purposes. For the oncology patient, the development of a family-focused, private room is mandatory. The private room is more flexible, less expensive to operate, safer and environmentally more appealing for the patient, family and staff.
Coronaviruses : molecular biology and virus-host interactions (1993)

Coronaviruses represent a major group of viruses of both molecular biological interest and clinical significance in animals and humans. The proceedings of the Fifth International Symposium on Coronaviruses, held in Chantilly, France, September 1992, provide a comprehensive view of the state of the a
ChemInform Abstract: Peptide Modification by Incorporation of α‐Trifluoromethyl . alpha.‐Amino Acids via Trifluoromethyl‐Substituted Acylimines. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
An Atomic Absorption Spectrophotometer (1963)

A double-beam, single-detector, time-sharing spectrophotometer has been designed with optimum parameters for the atomic absorption technique. The monochromator is a dual-grating, high-dispersion, Ebert–Fastie type. The major requirements of an atomic absorption spectrophotometer are stability, a wide range of slit-widths, and minimum sensitivity to emission from the flame. Many of the traditional requirements of an ultraviolet spectrophotometer can be relaxed. Ordinate scale expansion makes it possible to achieve lower detectability limits. With the present design, it has been possible to measure concentrations of less than 0.1 ppm of copper, cadmium, and chromium with coefficients of variation of less than 10%.
Synergistic Antiproliferative Effects of γ‐Tocotrienol and Statin Treatment on Mammary Tumor Cells (2007)

Statins are potent inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMGCoA) reductase and display anticancer activity, but their clinical use is limited by their high-dose toxicity. Similarly, gamma-tocotrienol, an isoform of vitamin E, also reduces HMGCoA reductase activity and displays potent anticancer activity. Studies were conducted to determine if combined low dose treatment of gamma-tocotrienol with individual statins resulted in a synergistic antiproliferative effect on neoplastic mouse +SA mammary epithelial cells. Treatment with 3-4 microM gamma-tocotrienol or 2-8 microM simvastatin, lovastatin or mevastatin alone resulted in a significant decrease, whereas treatment with 10-100 microM pravastatin had no effect on +SA cell growth. However, combined treatment of subeffective doses (0.25 or 10 microM) of individual statins with 0.25-2.0 microM gamma-tocotrienol resulted in a dose-responsive synergistic inhibition in +SA cell proliferation. Additional studies showed that treatment with subeffective doses of individual statins or gamma-tocotrienol alone had no effect, whereas combined treatment of these compounds resulted in a relatively large decrease in intracellular levels of phosphorylated (activated) MAPK, JNK, p38, and Akt. These findings strongly suggest that combined low dose treatment of gamma-tocotrienol with individual statins may have potential value in the treatment of breast cancer without causing myotoxicity that is associated with high dose statin treatment.
Effect of n-3 fatty acids on the antitumour effects of cytotoxic drugs. (2005)

These results suggest that n-3 fatty acids do not interfere with the action of chemotherapy and may potentiate the effect of certain agents.
Treatment Outcomes for Severe Feeding Problems in Children With Autism Spectrum Disorder (2009)

There is abundant research to support that children with autism spectrum disorder (ASD) exhibit challenging feeding behaviors. Despite increase in empirical evidence supporting the role of behavior analysis in treating severe feeding problems, evaluation of the short- and long-term effects of these treatments for a large group of children with ASD is warranted. The purpose of the current study was to evaluate treatment outcomes of an interdisciplinary feeding program for 46 children with ASD. A retrospective chart analysis indicated these children were treated successfully overall and follow-up data suggest gains were maintained following discharge from the program.
Application of Quasi-Linear Feedback to the Control of a Hard Disk Drive Servo System (2006)

This study illustrates the capability of quasi-linear systems to achieve arbitrarily high performance both in the time domain and the frequency domain of a linear plant, in this case a hard disk drive servo system
Produktwerbung und Verkaufsförderung im Privatkundengeschäft (1987)

Mit dem starken Wachstum des Privatkundengeschäfts, der deutlichen Wandlung vom Verkäufer- zum Käufermarkt für Bankdienstleistungen und dem entsprechend verschärften Wettbewerb erhielten Werbung und Verkaufsförderung als Marketing- Instrumente auch für die deutschen Geldinstitute einen zunehmenden Stellenwert. War die Geschäftspolitik in früheren Jahrzehnten eher von Zurückhaltung in werblichen Äußerungen geprägt — „Verkauf“ blieb im traditionsverbundenen Bankgewerbe lange ein Fremdwort -, so mußten sie diese nunmehr den veränderten Marktbedingungen anpassen. Eine wesentliche Voraussetzung hierfür war die wettbewerbspolitische Liberalisierung im Kreditgewerbe Ende der fünfziger Jahre sowie die deutliche Lockerung der Werbereglementierung für das Kreditwesen im Jahre 1967.
Software Fault Proneness Prediction Using Support Vector Machines (2009)

Abstract — Empirical validation of software metrics to predict quality using machine learning methods is important to ensure their practical relevance in the software organizations. In this paper, we build a Support Vector Machine (SVM) model to find the relationship between object-oriented metrics given by Chidamber and Kemerer and fault proneness. The proposed model is empirically evaluated using public domain KC1 NASA data set. The performance of the SVM method was evaluated by Receiver Operating Characteristic (ROC) analysis. Based on these results, it is reasonable to claim that such models could help for planning and performing testing by focusing resources on fault-prone parts of the design and code. Thus, the study shows that SVM method may also be used in constructing software quality models.
Structural Concrete Research and Development in New Zealand (1990)

Today the use of concrete as a construction medium for structures is commonplace. Most major buildings and bridges in New Zealand are made in this material. Other examples of the use of concrete abound, such as water retaining structures and marine structures.
CONTACT ALLERGY TO TEXTILE RESINS: AN UPDATE (1997)

Carroll, Patricia A. M.D.; Brown, Kenneth H. Ph.D.; Osburn, Anne H. R.N.; Scheman, Andrew J. M.D. Author Information
Effect of Moderate Salinity Stress on the Sugar Concentration and Fruit Yield in Single-truss, High-density Tomato Production System (2014)

To produce tomato fruits with 6% average Brix without decreasing yield, we investigated the effect of moderate salinity stress on Brix and yield in a single-truss, high-density tomato production system. Because tomato fruit development can be predicted from cumulative temperature, we also assessed cumulative temperature after anthesis as a potential indicator for determining the starting points of salinity stress treatments. When transverse diameters of the first fruit reached 4 cm (i.e., early increase treatment) or the first fruits were at the mature green stage (i.e., late increase treatment), nutrient solution electrical conductivity was slowly increased until the breaker stage from 1.8 dS·m−1 to 6.0 dS·m−1. Plants subjected to the late increase treatment produced tomato fruits with Brix values of 6% without reductions in marketable yield. We also increased nutrient solution electrical conductivity based on cumulative temperature after anthesis and found that early-treated plants produced tomatoes with higher Brix levels and yields than late-treated plants. In summary, moderate salinity stress to avoid excessive stress on plants increased sugar concentrations without decreasing fruit yield and resulted in tomato fruits with average Brix of about 6% when nutrient solution electrical conductivity was increased at a rate of 0.1 dS·m−1·day−1. Because seasonal differences in cumulative temperature influence the appropriate timing of salinity stress applications, further study is needed to optimize year-round growth under moderate salinity stress in single truss, high-density tomato production systems.
Reactive Ion Etching of Transparent Conducting Tin Oxide Films Using Electron Cyclotron Resonance Hydrogen Plasma (1988)

The dry etching of tin oxide films using electron cyclotron resonance (ECR) hydrogen plasma has been proposed. It is found that the etching rate is drastically increased by the use of reactive gases, such as n-butyl acetone, acetone, alchohols and methane, which are activated by the ECR hydrogen plasma. A high etching rate above 175 nm/min can be achieved by the use of n-butyl acetone as the reactive gas. The mechanism of reactive ion etching using the ECR hydrogen plasma has also been discussed.
FPGA-based computing in computer vision (2002)

Algorithms in computer vision are characterized by (i) complex and repetitive operations; (ii) large amount of data and (iii) a variety of data interaction (e.g., point operations, neighborhood operations, global operations). Based on the computation and communication complexity, vision algorithms have been characterized into three categories: (i) low-level, (ii) intermediate-level and (iii) high-level. In this paper, we describe the usage of custom computing approach to meet the computation and communication needs of computer vision algorithms. By customizing hardware architecture for every application at the instruction level, the optimal grain size needed for the problem at hand and the instruction granularity can be matched. Field Programmable Gate Array (FPGA) based processing elements (PEs) are being used to provide this facility. Using programmable communication resources, the diverse communication requirements can be met. A vision system needs to integrate hardware for the three levels. A custom computing approach alleviates the problem of achieving optimal granularity for different stages as the same hardware gets reconfigured at a software level for different levels of the application. We demonstrate the advantages of our approach using Splash 2-a Xilinx 4010-based custom computer.
A Smarter Smart Home: Case Studies of Ambient Intelligence (2012)

Technological support for sustainable home use lies in more subtle and contextually appropriate interventions that integrate informative models of occupant behavior, provide hybrid levels of automated control, and use ambient sensing for localized decisions.
FIRST AID IN THE AIR (1996)

Background: First aid is commonly required during commercial aircraft flights, especially during international flights. An intimidating and sometimes threatening array of in‐flight medical emergencies challenge the doctor, flight attendants and other passengers in such medical emergencies. Cramped conditions, difficulties of access to the victim, lack of privacy, cultural and language differences and noise and vibration all compound to increase the difficulties of the normal first aid drills which are required in the management of in‐cabin emergencies. Doctors who fly as passengers are liable to be called upon to render first aid in the air. We provide an analysis of the types of medical emergencies encountered during commercial air travel. Methods: We have reviewed all consecutive in‐flight medical incident reports for QANTAS international flights for 1993. All incidents requiring the attention of a doctor were included. Results: A total of 454 significant medical incidents occurred. These included, in rank order, syncope (35%), angina and cardiac emergencies (23%), gastrointestinal conditions (13%), respiratory tract infections and asthma (9%) and anxiety and panic reactions warranting medical intervention (5%). Conclusions: Syncope, the management of gastrointestinal symptoms and problems of angina comprise over half (58%) of the presenting symptoms which confront a fellow traveller who may coincidentally be a medical practitioner. Problems of anxiety, sleeplessness, airport bustle, immobility, barotrauma, alcohol abuse and mild hypoxia are discussed in the context of precipitating factors which may trigger an in‐flight emergency. Psychological problems are very common and challenge the first aider, whether or not he or she is medically trained. We emphasize the necessity for doctors and nurses to be trained in first aid, as a distinct profession in its own right and a series of drills and skills which are distinctive from those of surgery‐based health care. The 5% annual increase in air‐passenger traffic, predicted for the next two decades, highlights the importance of special training for ‘first aid in the air’.
Stochastic and deterministic absorption in neutron-interference experiments (1987)

Experiments with absorbing foils, beam choppers, or an absorbing lattice in one path of a neutron interferometer to expose the difference between stochastic and deterministic absorption in quantum mechanics are reported. The different amplitudes of the interference patterns in stochastic and deterministic absorption when the absorption probability is the same were observed in agreement with prediction. Also the possibility of a gradual transition from deterministic to stochastic absorption was experimentally investigated.
17O NMR of Enamino-Diesters: Intramolecular Hydrogen Bonding in 5-Alkylaminomethylene-2,2-dimethyl-1,3-dioxane-4,6-diones (1997)

Natural abundance 17O NMR spectra of a series of 5-alkylaminomethylene-2,2-dimethyl-1,3-dioxane-4,6-diones, recorded in acetonitrile solution, are reported. The δ(17O) values correlate well with those of 4-alkylaminobut-3-en-2-ones and with the pKa values of amines. The effects of the N-alkyl groups on the 17O shift values is diminished, owing to the resonance effects of the alkoxy groups. The shift difference (DδHB) between the two carbonyl groups is mainly attributed to the intramolecular hydrogen bonding and depends on the donor property of the amino group.
Wind tunnel testing of a smart rotor with induced-strain actuation of blade twist (1996)

This paper presents the experimental results of hover tests with a 1/8th dynamically-scaled (Froude scale) helicopter rotor model with embedded piezoceramic elements as actuators to suppress vibrations. A 6-ft diameter four-bladed bearingless rotor model was built with banks of specially-shaped piezoelectric actuators embedded at +/- 45 deg on the top and bottom surfaces to manipulate blade twist at harmonics of the rotational speed. The twist performance of rotors with single-layer and dual-layer actuator configurations was measured using accelerometers located at the blade tip. The change in oscillatory rotor lift due to piezoactuation was measured by a rotating balance. Experimental results show that linear twist distributions on the order of 0.3 deg, resulting in increases of up to 9 percent of the nominal rotor lift, are possible with existing piezoceramic technology. Although the twist amplitudes attained in this experiment were less than the target value (2 deg for complete vibration suppression), partial reduction of rotor vibrations can be achieved with the current smart rotors. (Author)
Active T-rosette-forming cells in the peripheral blood of cancer patients. (1976)

We studied a subpopulation of the thymus-dependent rosette-forming lymphocytes from the peripheral blood of normal individuals and of untreated patients with solid tumors or hematological cancers. This subpopulation of the thymus-dependent rosette-forming cells (T-RFC), termed the "active T-RFC," may be relatively more immunocompetent than the total thymus-dependent population. The mean percentages and absolute numbers of active T-RFC of 40 healthy adult controls were 25.8 +/- 4.3 and 626 +/- 213, respectively. There was no difference in the percentage of active T-RFC between the controls (smokers and nonsmokers) and the 102 untreated patients with solid (localized or metastasized) tumors, 4 patients with Hodgkin's disease, or the 10 patients with non-Hodgkin's lymphomas. However, the absolute number of active T-RFC was significantly less in the cancer patients than in the controls. Eight patients with chronic lymphocytic leukemia had lower percentages but higher absolute numbers of active T-RFC, whereas 6 patients with multiple myeloma had higher percentage and lower absolute numbers than the controls. Following radiation therapy, 61 patients with solid tumors showed no difference in the percentage of active T-RFC, but the corresponding absolute numbers declined significantly. A good correlation was seen with patients having positive microbial skin test responses and normal percentage of active T-RFC. The significance of both the percentages and absolute numbers of active T-RFC and their relationship to patient status are discussed.
Expression of a truncated EGF receptor is associated with inhibition of pancreatic cancer cell growth and enhanced sensitivity to cisplatinum (1996)

Human pancreatic cancers over-express the epidermal growth factor receptor (EGF-R) and all 5 known ligands of the EGF family, including EGF, transforming growth factor-alpha (TGF-alpha), amphiregulin, betacellulin and heparin-binding EGF-like growth factor (HB-EGF). The aim of the present study was to confirm the presence of EGF-R-dependent autocrine loops in a human pancreatic cancer cell line and to explore the possibility that interrupting EGF-R activation by introducing a truncated receptor abrogates pancreatic cancer cell growth. The anchorage-independent growth of PANC-1 human pancreatic cancer cells, previously shown to express TGF-alpha, was inhibited by specific anti TGF-alpha antibodies. PANC-1 cells were then either transfected with an expression plasmid encoding a kinase-deficient EGF-R cDNA (HER653) or infected with the same EGF-R cDNA using a retroviral vector. Multiple transfected and infected clones co-expressed the truncated EGF-R and endogenous EGF-R as revealed by Northern blot analysis and immunoblots. In these clones, there was a marked attenuation in EGF- and TGF-alpha-mediated EGF-R tyrosine phosphorylation and c-fos induction. There was also a significant decrease in colony formation in soft agar by comparison with control cells and a significant increase in the effect of the growth-inhibitory effect of the alkylating agent cisplatinum in these clones. Our observations indicate that dominant negative inhibition of EGF-R may have therapeutic potential in pancreatic cancer.
Characteristics of aligned carbon nanofibers for interconnect via applications (2006)

Electrical properties of plasma-enhanced chemical vapor deposited carbon nanofibers (CNFs) are characterized with measurements over a broad temperature range (4-300 K). Temperature-dependent measurements of CNF via resistivity reveal a behavior resembling the mixture of graphite a-axis and c-axis transport mechanisms. For the first time, temperature-dependent characteristics of CNFs are measured and modeled based on previously developed models for electron conduction in graphite. Reliability measurements are performed to demonstrate the robust electrical and thermal properties of CNF vias for next-generation on-chip-interconnect designs.
Protoplast preparation and regeneration in Nocardia mediterranei (1986)

A standard procedure for the preparation of viable Streptomyces protoplasts was found to be unsuccessful for the rifamycin-producing actinomycete Nocardia mediterranei. An alternative method for N. mediterranei protoplast preparation is described. This method was also found to be applicable to several other ansamycin-producing actinomycetes.