gebhart/patrepeval huggingface dataset:
Testing linear macros in mixed-signal systems usingtransientresponse testing and dynamic supply current monitoring (1994)

Transient response testing (TRT) has been shown to be a powerful technique for the testing of linear macros in mixed-signal systems. Its most significant advantage is the ease with which the generic digital stimuli can be injected into, and propagated through, a mixed-signal system. However, with a deeply buried macro the resulting response is difficult to access, and these benefits cannot be fully exploited. The authors show how this problem can be overcome by forcing the transient response of interest to manifest itself in the device supply current, and also present a silicon efficient serial digital test access structure.
Themolecular basis ofgenetic dominance (1994)

Studiesofmutagenesis inmany organismsindicate thatthemajority(over 90%)ofmutations are recessive towild type. If recessiveness representsthe 'default' state,whatare thedistinguishingfeatures thatmake a minorityof mutations giverisetodominantor semidominantcharacters? Thisreviewdraws on therapidexpansion inknowledgeof molecular andcellular biology toclassify themolecular mechanismsofdominant mutation.The categories discussed include(1)reducedgene dosage, expression,or proteinactivity (haploinsufficiency); (2)increased gene dosage;(3) ectopic or temporally alteredmRNA expression; (4)increased or constitutive proteinactivity; (5)dominantnegative effects; (6)altered structural proteins; (7) toxicproteinalterations; and (8)new protein functions. Thisprovides a frameworkforunderstanding thebasisofdominantgenetic phenomenainhumansand otherorganisms. (JMedGenet1994;31:89-98)
Monitoring of<i>Saccharomyces</i>and<i>Hanseniaspora</i>populations during alcoholic fermentation by real-time quantitative PCR (2007)

Real-time, or quantitative, PCR (QPCR) was developed for the rapid quantification of two of the most important yeast groups in alcoholic fermentation (Saccharomyces spp. and Hanseniaspora spp.). Specific primers were designed from the region spanning the internal transcribed spacer 2 (ITS2) and the 5.8S rRNA gene. To confirm the specificity of these primers, they were tested with different yeast species, acetic acid bacteria and lactic acid bacteria. The designed primers only amplified for the intended group of species and none of the PCR assays was positive for any other wine microorganisms. This technique was performed on reference yeast strains from pure cultures and validated with both artificially contaminated wines and real wine fermentation samples. To determine the effectiveness of the technique, the QPCR results were compared with those obtained by plating. The design of new primers for other important wine yeast species will enable to monitor yeast diversity during industrial wine fermentation and to detect the main spoilage yeasts in wine.
An Advanced Selenium–Carbon Cathode for Rechargeable Lithium–Selenium Batteries (2013)

Selenium has been confined in the form of cyclic Se8 molecules within ordered mesoporous carbon for use as a cathode material in Li–Se batteries. An ex situ study of the Se cathode reveals conversion from cyclic Se8 molecules into chain-like Sen molecules upon cycling. This effectively eliminates the shuttle effect of Se, resulting in superior electrochemical performance in terms of volumetric capacity density and cycling stability. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Design and characteristic analysis of inverter driven induction machine with field weakening operation (2003)

Characteristics of design and magnetic field analysis of induction machine (IM) with field weakening operation are investigated. Design objective and constraints, which are related to performance requirements of increased constant power range and speed limit, can be defined preliminarily, and the designed IM prototype for field weakening will be proposed. Subsequently, nonlinear magnetic field analysis with input voltage source is performed to the designed IM.
Adaptation of Ordering Techniques for Facsimile Pictures with No Single Element Runs (1979)

We present a simple strategy for modification of two-level facsimile pictures and adapt our earlier published ordering techniques to take advantage of the modification. Picture modification consists of eliminating all horizontal runs of “black” or “white” elements which are of length one. For pictures with high resolution (e.g., 200 dots/inch), such a modification does not excessively degrade the picture quality. The resulting entropy of the coded pictures is between 0.018 to 0.115 bits/pel for the eight ccitt pictures, which are scanned and sampled at approximately 200 dots/inch. This amounts to an average reduction of 48 percent compared to one-dimensional run-length coding and 10 percent compared to our previously published best ordering technique.
Outbreak of tetanus cases following the tsunami in Aceh province, Indonesia (2006)

Aceh Province in Indonesia was the area most severely affected by the tsunami of 26 December 2004. Extensive loss of life, property, and livelihood left a large segment of the population without basic needs and vulnerable to epidemic-prone diseases. Following the tsunami, a surveillance/early warning and response system was implemented to detect, investigate, and respond to outbreaks of communicable diseases. Fixed and mobile clinics, hospitals, and laboratories, operating all over the affected areas, reported weekly figures and daily alerts. Over 1 month following the tsunami, 106 cases of clinically diagnosed tetanus were reported. Most cases occurred among adults. The case fatality ratio was 18.9%, higher among older patients and among those with short incubation periods. No other major outbreaks occurred in the acute phase of the emergency. This series of tetanus cases was the largest cluster reported following a natural disaster or mass casualty event, overtaken only by the recent earthquake in the Kashmir (139 cases reported), and reflects the high number of injuries which occurred during the tsunami and poor prior immunization status of the population. In the context of natural disasters, preventive measures against tetanus, including wound cleaning and active and passive immunization, should be routinely conducted. Immediate disaster relief should include supplies for the management of wounds and cases of tetanus.
Blade System Design Studies phase II : final project report. (2008)

No abstract prepared.
Noninvasive recording of His-Purkinje activity in patients with complete atrioventricular block. Clinical application of an "automated discrimination circuit". (1979)

In seven patients with complete atrioventricular (AV) block, His bundle electrograms (HBEs), standard ECG recordings, bipolar esophageal ECGs and highly amplified, filtered, bipolar chest lead ECGs were simultaneously recorded. The filtered chest lead ECG was averaged to determine His-Purkinje activity (HPA). A simplified device, the "automated discrimination circuit," was used to selectively eliminate the superimposed atrial and ventricular potentials that are characteristic of complete AV block and unsuitable for signal averaging. The processed chest lead ECG was amenable to conventional techniques of signal averaging. In four patients with block proximal to the AV node diagnosed by HBE, there was no activity after the P wave in the surface-averaged ECGs. HPA was consistently recorded before the QRS in the surface-averaged ECG. The measurements of the HV and HPA-V intervals were very close, with a difference of less than 2 msec. Three patients with block distal to the His bundle by HBE showed a loss of electrical potential before the QRS in the surface-averaged ECG, but had a consistent HPA after the P waves. The P-HPA intervals coincided well with PH intervals, with a maximal difference of 5 msec.
Multichannel music separation with deep neural networks (2016)

This article addresses the problem of multichannel music separation. We propose a framework where the source spectra are estimated using deep neural networks and combined with spatial covariance matrices to encode the source spatial characteristics. The parameters are estimated in an iterative expectation-maximization fashion and used to derive a multichannel Wiener filter. We evaluate the proposed framework for the task of music separation on a large dataset. Experimental results show that the method we describe performs consistently well in separating singing voice and other instruments from realistic musical mixtures.
Hybrid five-level T-type inverter (2014)

Multilevel inverters have proven to be a solid technology in electrical drive applications. A new voltage source multilevel converter topology, that is a hybrid between three-level flying capacitor and T-type inverters, is introduced. The proposed topology can produce live output voltage levels. This paper presents the principle of operation for the topology, including the control of the flying capacitor voltage. The inverter operation is simulated and the loss distribution over the phase leg devices is presented.
Prediction of multidimensional drug dose responses based on measurements of drug pairs (2016)

Finding potent multidrug combinations against cancer and infections is a pressing therapeutic challenge; however, screening all combinations is difficult because the number of experiments grows exponentially with the number of drugs and doses. To address this, we present a mathematical model that predicts the effects of three or more antibiotics or anticancer drugs at all doses based only on measurements of drug pairs at a few doses, without need for mechanistic information. The model provides accurate predictions on available data for antibiotic combinations, and on experiments presented here on the response matrix of three cancer drugs at eight doses per drug. This approach offers a way to search for effective multidrug combinations using a small number of experiments.
The use of Lawsonia inermis linn. (henna) in the management of burn wound infections (2005)

The effects of water and chloroform extracts of the leaves of Lawsonia inermis (henna plant) against the primary invaders of burnt wounds was investigated. Clinical isolates of Staphylococcus aureus, Streptococcus sp, Pseudemonas aeruginosa, Candida albicans, Fusarium oxysporum, and Aspergillus niger were treated with extracts of the leaves of L. inermis for antimicrobial activity using in vitro agar incorporation method and well diffusion methods respectively. The henna leaves extracts were able to inhibit the growth pattern of A. niger and F. oxysporum. Streptococcus sp. and S. aureus were also inhibited by the extracts. Inhibition of the microorganisms’ growth suggests that henna may be valuable in the management of burnt wound infections.
A Room with a Viewpoint: Using Social Norms to Motivate Environmental Conservation in Hotels (2008)

Abstract Two field experiments examined the effectiveness of signs requesting hotel guests' participation in an environmental conservation program. Appeals employing descriptive norms (e.g., “the majority of guests reuse their towels”) proved superior to a traditional appeal widely used by hotels that focused solely on environmental protection. Moreover, normative appeals were most effective when describing group behavior that occurred in the setting that most closely matched individuals' immediate situational circumstances (e.g., “the majority of guests in this room reuse their towels”), which we refer to as provincial norms. Theoretical and practical implications for managing proenvironmental efforts are discussed.
SOAP Optimization via Client Side Caching. (2003)

We present the first draft whole-genome sequence for the Parmales (Bolidophyceae, Heterokonta), a picoplanktonic sister group of diatoms, using a <i>Triparma laevis</i> f. <i>inornata</i> strain that was isolated from the Oyashio region in the western North Pacific Ocean.
Multivariate optimization of production systems: The time dimension (1993)

Traditional analysis of oil and gas production systems treats individual nodes one at a time. This only calculates a feasible solution which is not necessarily optimal. Multivariate optimization is able to determine the most profitable configuration, including all variables simultaneously. The optimization can also find the optimal recovery over a period of time, rather than just at a single instant as in traditional methods. This report describes the development of multivariate optimization for situations in which the decision variables may change as a function of time. For example, instead of estimating a tubing size which is optimal over the life of the project, this approach determines a series of optimal tubing sizes which may change from year to year. Examples show that under an optimal strategy, tubing size can be changed only infrequently while still increasing profitability of a project. The methods used in this work considered the special requirements of objectives which are not smooth functions of their decision variables. The physical problems considered included artificial lift production systems.
Oscillation monitoring system based on wide area synchrophasors in power systems (2007)

With the growing implementation of synchrophasors or PMU's across the power grid, it is now possible to observe and analyze system wide dynamic phenomena in real-time. This paper presents the framework of an automatic real-time oscillation monitoring expert system for extracting the modal information and mode shape of electromagnetic oscillations while they are still emerging in the real power system. The algorithms use three signal processing engines, namely, Prony's method, matrix pencil method and Hankel total least squares (HTLS) method. Results from these engines are processed using a custom developed set of rules for handling the complexities of modal analysis from real-time PMU measurements. The results are illustrated on several actual PMU recordings from power systems in North America. A simple powerful control design is also explored to initiate a supplementary HVDC modulation scheme to damp out inter-area oscillations when the oscillation monitoring system detects poorly damped oscillations.
Baculovirus-mediated expression of the epidermal growth factor-like modules of human factor IX fused to the factor XIIIa transamidation site in fibronectin. Evidence for a direct interaction between the NH2-terminal epidermal growth factor-like module of factor IXa beta and factor X. (1994)

Factor IX is a vitamin K-dependent procoagulant zymogen of a serine protease. In the presence of Ca2+ the active form of factor IX (factor IXa beta) forms a complex with factor VIIIa on suitable phospholipid surfaces such as aggregated platelets. This macromolecular complex rapidly activates factor X. We have previously provided data that suggest an interaction between the NH2-terminal epidermal growth factor (EGF)-like module of factor IXa beta and the substrate factor X. In an alternative approach to study this protein-protein interaction, we have expressed three recombinant baculovirus constructs encoding the EGF-like modules of human factor IX and a truncated form of fibronectin in a system based on the infection of insect cells (Spodoptera frugiperda 21). This strategy allows a simple one-step purification of the recombinant proteins on a gelatin-Sepharose column, followed by removal of the gelatin-binding part derived from fibronectin by proteolytic cleavage. The fusion proteins were isolated at yields of 20-50 micrograms/ml culture medium. The recombinant EGF-like modules contained 0.2-0.4 mol of erythro-beta-hydroxyaspartic acid/mol of protein, i.e. similar to the amount found in factor IX from human plasma, and appeared to be glycosylated at Ser-53. The NH2-terminal EGF-like module, which contained a transamidation acceptor site derived from fibronectin, was cross-linked by factor XIIIa in solution to intact and Gla-domainless factor X. There was no evidence of cross-linking to activated factor X or to factor X fragments containing only the gamma-carboxyglutamic acid module and the two EGF-like modules. The cross-linking results suggest a specific interaction between the NH2-terminal EGF-like module of factor IXa beta and the heavy chain of unactivated factor X. This interaction, albeit weak as judged by competition experiments, may be important for the targeting of factor X to the factor IXa beta-factor VIIIa complex on biological membranes and for the subsequent dissociation of factor Xa from the complex after activation.
The Effects of Cyclic Hydrostatic Pressure on Chondrogenesis and Viability of Human Adipose- and Bone Marrow-Derived Mesenchymal Stem Cells in Three-Dimensional Agarose Constructs (2012)

This study investigates the effects of cyclic hydrostatic pressure (CHP) on chondrogenic differentiation of human adipose-derived stem cells (hASCs) in three-dimensional (3-D) agarose constructs maintained in a complete growth medium without soluble chondrogenic inducing factors. hASCs were seeded in 2% agarose hydrogels and exposed to 7.5 MPa CHP for 4 h per day at a frequency of 1 Hz for up to 21 days. On days 0, 7, 14, and 21, the expression levels of collagen II, Sox9, aggrecan, and cartilage oligomeric matrix protein (COMP) were examined by real-time reverse transcriptase-polymerase chain reaction analysis. Gene expression analysis found collagen II mRNA expression in only the CHP-loaded construct at day 14 and at no other time during the study. CHP-loaded hASCs exhibited upregulated mRNA expression of Sox9, aggrecan, and COMP at day 7 relative to unloaded controls, suggesting that CHP initiated chondrogenic differentiation of hASCs in a manner similar to human bone marrow-derived mesenchymal stem cells (hMSC). By day 14, however, loaded hASC constructs exhibited significantly lower mRNA expression of the chondrogenic markers than unloaded controls. Additionally, by day 21, the samples exhibited little measurable mRNA expression at all, suggesting a decreased viability. Histological analysis validated the lack of mRNA expression at day 21 for both the loaded and unloaded control samples with a visible decrease in the cell number and change in morphology. A comparative study with hASCs and hMSCs further examined long-term cell viability in 3-D agarose constructs of both cell types. Decreased cell metabolic activity was observed throughout the 21-day experimental period in both the CHP-loaded and control constructs of both hMSCs and hASCs, suggesting a decrease in cell metabolic activity, alluding to a decrease in cell viability. This suggests that a 2% agarose hydrogel may not optimally support hASC or hMSC viability in a complete growth medium in the absence of soluble chondrogenic inducing factors over long culture durations. This is the first study to examine the ability of mechanical stimuli alone, in the absence of chondrogenic factors transforming growth factor beta (TGF-β)3, TGF-β1 and/or bone morphogenetic protein 6 (BMP6) to induce hASC chondrogenic differentiation. The findings of this study suggest that CHP initiates hASC chondrogenic differentiation, even in the absence of soluble chondrogenic inductive factors, confirming the importance of considering both mechanical stimuli and appropriate 3-D culture for cartilage tissue engineering using hASCs.
[Expression and functional analysis of CRT-E2-EGFP fusion protein in B16 cells]. (2009)

The eukaryotic expression plasmid pEGFP-CRT-E2 is successfully constructed and it could correctly express the fusion protein in B16 cells. And the B16 cells transfected by plasmid pEGFP-CRT-E2 could induce apoptosis.
The Use of Ipso-dihydrodiols Enzymatically Derived from Benzoic Acid in Enantioselective Synthesis. Appoaches to Total Synthesis of Vinca Alkaloids (2014)

The present studies describe our recent progress in target oriented synthesis of complex organic molecules from aromatic precursors. The latest synthetic approaches toward vinca alkaloids are described and include the construction of model substrates for the investigation into Diels-Alder, radical cascade, and tandem Michael addition reactions as possible routes to the family of alkaloids. Also described are the chemoenzymatic syntheses of the natural product (-)-idesolide and unnatural polyhydroxylated pyrrolidines generated from the biotransformation of benzoic acid with Ralstonia eutropha B9.
Cryopreservation of human bone marrow‐derived mesenchymal stem cells with reduced dimethylsulfoxide and well‐defined freezing solutions (2010)

The aim of this study is to investigate the feasibility of using well defined, serum-free freezing solutions with a reduced level of dimethylsulfoxide (DMSO) of 7.5, 5, and 2.5% (v/v) in the combination with polyethylene glycol (PEG) or trehalose to cryopreserve human bone marrow-derived mesenchymal stem cells (hBMSCs), a main source of stem cells for cell therapy and tissue engineering. The standard laboratory freezing protocol of around 1°C/min was used in the experiments. The efficiency of 1,2-propandiol on cryopreservation of hBMSCs was explored. We measured the post-thawing cell viability and early apoptotic behaviors, cell metabolic activities, and growth dynamics. Cell morphology and osteogenic, adipogenic and chondrogenic differentiation capability were also tested after cryopreservation. The results showed that post-thawing viability of hBMSCs in 7.5% DMSO (v/v), 2.5% PEG (w/v), and 2% bovine serum albumin (BSA) (w/v) was comparable with that obtained in conventional 10% DMSO, that is, 82.9 ± 4.3% and 82.7 ± 3.7%, respectively. In addition, 5% DMSO (v/v) with 5% PEG (w/v) and 7.5% 1,2-propandiol (v/v) with 2.5% PEG (w/v) can provide good protection to hBMSCs when 2% albumin (w/v) is present. Enhanced cell viability was observed with the addition of albumin to all tested freezing solutions.
プログラミング : Jakarta Struts (2003)

Ｗｅｂ層の内部 Ｓｔｒｕｔｓフレームワークの概要 Ｓｔｒｕｔｓアプリケーションの設定 Ｓｔｒｕｔｓのコントローラコンポーネント Ｓｔｒｕｔｓのモデルコンポーネント Ｓｔｒｕｔｓのビューコンポーネント ＪＳＰのカスタムタグライブラリ Ｓｔｒｕｔｓフレームワークの拡張 例外処理 Ｖａｌｉｄａｔｏｒフレームワーク 国際化とＳｔｒｕｔｓ ＳｔｒｕｔｓとＥＪＢ Ｔｉｌｅｓの使用 Ｓｔｒｕｔｓアプリケーションでのロギング Ｓｔｒｕｔｓアプリケーションのパッケージ化 パフォーマンスへの対処
Internet Applications over Native ATM. (1998)

Current Internet applications can not take advantage of the variety of service classes offered by ATM networks. This is due to the stacking, without specific scheduling mechanisms, of a best-effort network layer on top of ATM. Simultaneously, few native ATM applications have been written specifically in this networking framework. We propose an architecture for running TCP-based applications over ATM. This architecture relies on the standard TCP protocol and offers at the socket layer the means to specify an ATM traffic contract. This gives an immediate native ATM access to a rich set of familiar applications. It also helps satisfy the increasing need of resource control for Internet applications. We have developed TCP-ONIP (TCP over non existent IP), a prototype implementation of this approach. The necessary adaptation steps are shown in the case of the Web. Keywords: ATM, Internet, native applications, QoS 1. Introduction Recent years have shown an intense work on ATM (Asynchronous T...