gebhart/patrepeval huggingface dataset:
Licorice Inhibits Corticosteroid 1lβ-Dehydrogenase of Rat Kidney and Liver:<i>In Vivo</i>and<i>in Vitro</i>Studies* (1989)

In humans, glycyrrhetinic acid (GE), the active pharmacological ingredient of licorice, produces symptoms resembling those caused by excess mineralocorticoid secretion. We are proposing that 11 beta-dehydrogenase inhibition, and not intrinsic mineralocorticoid activity, is the primary mechanism of licorice induced pseudoaldosteronism. Glycyrrhizic acid (glycyrrhetinic acid glucuronide), when given orally to rats, partially inhibited renal 11 beta-dehydrogenase. In rats treated with dexamethasone before glycyrrhizic acid administration there was similar enzyme inhibition, suggesting that antimineralocorticoid effects of dexamethasone in licorice excess states are not mediated through a direct effect on 11 beta-dehydrogenase activity. Dispersed renal proximal tubular preparations, kidney homogenates, and microsomes readily converted corticosterone to 11-dehydrocorticosterone. GE and its synthetic analog carbenoxolone inhibited the conversion in these systems in a dose-dependent manner. Corticosteroid 11-oxoreductase, which was present in kidney homogenates at a level 10-20% that of 11 beta-dehydrogenase was not inhibited by any of the agents. With homogenate and microsomes, the Ki of GE was about 10(-9)-10(-8) M; with intact tubules, the Ki of GE was about 10(-5)-10(-6) M. It is suggested that a permeability barrier slows the entry of GE into the tubule cells. We conclude that the effects of licorice on corticosteroid metabolism in the kidney are based on its inhibition of 11 beta-dehydrogenase. Our data, supplemented by published evidence, is inconsistent with the conclusion that interaction with mineralocorticoid receptors accounts for the pharmacological effects of GE.
<title>Imaging Techniques Implemented On Pipeline Minis And An Array Processor With Application To Nerve Fiber Counting</title> (1979)

A pipeline approach to processing of digitized picture data using multiple mini computers and an array processor is presented. Picture size can be up to 512 by 512 pixels. Implementing of many heuristic algorithms such as edge detection, edge enhancin2', convolution/ correlation of template, peak detection, fast fourier transforms, filtering, summing two pictures, registration, histogram equaiization, thresholding and object counting, is determining and application is made to a nerve fiber counting project. The goals of the medical project are to provide data to be used in determing optimal surgical repair of injured or severed nerve and time scale as well as a percent of recovery of function following surgical repair. A simple operating system is described to invoke specific routines in the needed order in designated processors. Three approaches are discussed to the problem of image enhancement, pattern recognition and display of a picture consisting of multiple scenes or an object which is captured in the form of multiple "slices" through the object.
Exacerbation of inflammatory bowel disease by nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 inhibitors: Fact or fiction (2006)

The existence of a possible link between inflammatory bowel disease (IBD) and nonsteroidal anti-inflammatory drugs (NSAIDs) has been repeatedly suggested. Recently, a few studies have addressed the issue of a possible, similar effect by selective cyclooxygenase-2 inhibitors (COXIBs). The present article reviews the available scientific evidence for this controversial subject.
Human-in-the-Loop Mobile Networks: A Survey of Recent Advancements (2017)

Recent developments of smart devices and mobile applications have significantly increased the level at which human users interact with mobile systems. As a result, human activities, usage behavior, and perceived experience of users weigh increasingly on the performance of mobile networks, which has created new challenges for system operation in various aspects, such as increasing uncertainty, selfishness in operations, and complicated performance evaluation. On the other hand, the strong engagement of a large population of human users makes it possible to take advantage of the unique features of human behavior and to leverage the computing powers owned by users. Due to these emerging features of mobile networks, their design and evaluation require a hybrid view of human factor and information technology, and a paradigm shift is required for designing a new human-in-the-loop architecture by actively learning, adapting, and steering user behavior, so as to exploit the human factor in future ubiquitous mobile systems, and to greatly enhance system efficiency and provide superior quality-of-experience to users. The goal of this survey is to summarize recent results that focus on understanding and exploiting the human factor in mobile networks. In the tutorial, we summarize and discuss novelties of these formulations, adopted methodologies, and interesting results. We also point out some future research directions.
An Innovative Approach in Designing an Electronic Instrument Cluster (1981)

<div class="htmlview paragraph">Chrysler Corporation's new 1981 Imperial introduces an unprecedented totally electronic digital instrument cluster, which features five vacuum fluorescent displays and nine low-travel push buttons for function selection. It is the intention of this paper to present the innovative aspects of the Imperial Instrument Cluster design and how Chrysler met the challenges of utilizing electronics in the automotive environment.</div>
Lossless compression algorithm for REBL direct-write e-beam lithography system (2010)

Future lithography systems must produce microchips with smaller feature sizes, while maintaining throughputs comparable to those of today's optical lithography systems. This places stringent constraints on the effective data throughput of any maskless lithography system. In recent years, we have developed a datapath architecture for direct-write lithography systems, and have shown that compression plays a key role in reducing throughput requirements of such systems. Our approach integrates a low complexity hardware-based decoder with the writers, in order to decompress a compressed data layer in real time on the fly. In doing so, we have developed a spectrum of lossless compression algorithms for integrated circuit layout data to provide a tradeoff between compression efficiency and hardware complexity, the latest of which is Block Golomb Context Copy Coding (Block GC3). In this paper, we present a modified version of Block GC3 called Block RGC3, specifically tailored to the REBL direct-write E-beam lithography system. Two characteristic features of the REBL system are a rotary stage resulting in arbitrarily-rotated layout imagery, and E-beam corrections prior to writing the data, both of which present significant challenges to lossless compression algorithms. Together, these effects reduce the effectiveness of both the copy and predict compression methods within Block GC3. Similar to Block GC3, our newly proposed technique Block RGC3, divides the image into a grid of two-dimensional "blocks" of pixels, each of which copies from a specified location in a history buffer of recently-decoded pixels. However, in Block RGC3 the number of possible copy locations is significantly increased, so as to allow repetition to be discovered along any angle of orientation, rather than horizontal or vertical. Also, by copying smaller groups of pixels at a time, repetition in layout patterns is easier to find and take advantage of. As a side effect, this increases the total number of copy locations to transmit; this is combated with an extra region-growing step, which enforces spatial coherence among neighboring copy locations, thereby improving compression efficiency. We characterize the performance of Block RGC3 in terms of compression efficiency and encoding complexity on a number of rotated Metal 1, Poly, and Via layouts at various angles, and show that Block RGC3 provides higher compression efficiency than existing lossless compression algorithms, including JPEG-LS, ZIP, BZIP2, and Block GC3.
A survey on saffron in major islamic traditional medicine books. (2013)

Islamic Traditional Medicine (ITM) is a holistic system of medicine. Saffron (Crocus sativus) is one of the most famous plants cultivated in Iran and has a wide range of activities such as oxytocic, anti-carcinogenic, exhilarant, anti-depressant, and anti-asthma effects. In addition, saffron can increase the bioavailability and enhance absorption of other drugs. This study comprises a bibliographical survey of 13 major ITM books regarding different medical aspects of this species. Ferdows al-Hekmah fi'l-Tibb (The Paradise of Wisdom in Medicine), Al-Hawi fi'l-Tibb (Comprehensive Book of Medicine), Kamel al-Sanaat al-Tibbyyah (Complete Book of the Medical Art), Al-Qanun fi'l-Tibb (Canon of Medicine), Zakhireh Kharazmshahi (Treasure of Kharazmshahi), and Makhzan al-Adwiah (Drug Treasure) are some of the most important ITM books used in this survey.
GRAFT VS. HOST REACTION GENERATED BY PORCINE LIVERS PERFUSED WITH HUMAN BLOOD. (1999)

861 We have successfully perfused porcine livers with human blood for up to 72 hours using an extracorporeal perfusion apparatus. Previous work demonstrated that these perfused livers exhibit metabolic and synthetic function approaching normal parameters. We now present evidence that porcine livers perfused with human blood generate both humoral and phagocytic cell mediated graft vs. host reactions. Over the course of a 3 day perfusion, the hematocrit of the perfusing human blood decreased to 15 % of starting value (non-transgenic livers, n=5) and < 1% (transgenic livers, n=5). In contrast, the hematocrit of porcine blood perfusing porcine livers (n=5) decreased to 85% of starting value. Immunohistochemistry, light microscopy and electron microscopy (transmission and scanning) have implicated porcine Kupffer cells as the main source of red cell loss. Direct and indirect assays for porcine anti-human red blood cell (RBC) antibodies have failed to demonstrate a role of antibodies in this erythrocyte loss. Evidence of complement production has been demonstrated. After 68 hours perfusion, mean complement activity (CH50) was 110% of starting value (anhepatic control 0%). While this complement is capable of causing lysis of sheep RBC, lysis of human RBC has not been demonstrated. ELISA analysis demonstrated porcine IgG (transgenic 203 μg/ml, non-transgenic 94 μg/ml, normal pig serum control 6836 μg/ml) and porcine IgM (transgenic 33 μg/ml, non-transgenic 28 μg/ml, normal pig serum control 2101 μg/ml) in the human blood following porcine liver perfusion. FACS analysis showed that a proportion of these antibodies were specific for antigens on fresh human WBC. In 3 of 5 transgenic and 2 of 5 non-transgenic liver perfusions, human-specific porcine IgG levels increased with time suggesting a response by previously primed lymphocytes. Thus, while humoral mechanisms have not been implicated as a cause of the erythrocyte loss during porcine liver perfusion with human blood, a rapid (within 3 days) anti-human porcine immunoglobulin and phagocytic cell response has been demonstrated.
The effects of age and cochlear hearing loss on temporal fine structure sensitivity, frequency selectivity, and speech reception in noise (2011)

Temporal fine structure (TFS) sensitivity, frequency selectivity, and speech reception in noise were measured for young normal-hearing (NHY), old normal-hearing (NHO), and hearing-impaired (HI) subjects. Two measures of TFS sensitivity were used: the "TFS-LF test" (interaural phase difference discrimination) and the "TFS2 test" (discrimination of harmonic and frequency-shifted tones). These measures were not significantly correlated with frequency selectivity (after partialing out the effect of audiometric threshold), suggesting that insensitivity to TFS cannot be wholly explained by a broadening of auditory filters. The results of the two tests of TFS sensitivity were significantly but modestly correlated, suggesting that performance of the tests may be partly influenced by different factors. The NHO group performed significantly more poorly than the NHY group for both measures of TFS sensitivity, but not frequency selectivity, suggesting that TFS sensitivity declines with age in the absence of elevated audiometric thresholds or broadened auditory filters. When the effect of mean audiometric threshold was partialed out, speech reception thresholds in modulated noise were correlated with TFS2 scores, but not measures of frequency selectivity or TFS-LF test scores, suggesting that a reduction in sensitivity to TFS can partly account for the speech perception difficulties experienced by hearing-impaired subjects.
Real-Time Electronic Monitoring of Adsorption Kinetics:  Evidence for Two-Site Adsorption Mechanism of Dicarboxylic Acids on GaAs(100) (1998)

We show that the chemisorption of dicarboxylic acids on GaAs (100) is described well by a two-site mechanism, in contrast to benzoic acid adsorption which fits to a one-site mechanism. We do so by using a novel electrical method for direct measurement of adsorption kinetics. In the method we measure the current through a GaAs/(Al, Ga)As-based device, where the bare surface between two contacts is used as the adsorption domain. The results, which are in agreement with FTIR absorption equilibrium data, are obtained in ambient notwithstanding the notorious instability of GaAs surfaces under such conditions. We conclude that these acids chemisorb on the GaAs surface and that binding is significantly stronger for the di- than for the monocarboxylic acids.
Variation of Agronomic Characters in the Yearling of Ginseng Plants (1979)

Present studies were carried out to clarify the variation of agronomic characters of Panax ginseng (violet-stem variant and yellow-berry variant) and Panax quinquefolium (American ginseng). The variations of stem diameter. stem length, leaf width, root diameter. and root length of Panax quinquefolium were found to be more variable as compared with those of Panax ginseng. As for the variations of agronomic characters of Panax ginseng. violet-stem variant was more variable than yellow-berry variant. In Panax ginseng as well as Panax quinquefolium . the variability of stem length. leaf length, and root length was high. while the other agronomic characters showed comparatively low variability.
Optical frequency-domain imaging microprofilometry with a frequency-tunable liquid-crystal Fabry–Perot etalon device (1999)

An optical frequency-domain interference microscope with a liquid-crystal Fabry-Perot interferometer as an optical frequency-scan device was developed for microscopic three-dimensional shape measurements. The proposed system can perform absolute measurement of the discontinuous surface profile of a microscopic object without use of mechanically moving components such as a piezoelectric transducer or a grating spectrometer. Experimental results are presented that demonstrate the validity of the principle.
Linker peptide and affinity tag for detection and purification of single-chain Fv fragments (2004)

The peptide tag GATPQDLNTML, corresponding to amino acids 46-56 of the human immunodeficiency virus type 1 (HIV-1) capsid protein p24, is the linear epitope of the murine monoclonal antibody CB4-1. This antibody shows high affinity (KD = 1.8 x 10(-8) M) to the free epitope peptide in solution. The original p24 peptide tag and mutant derivatives were fused to the C terminus of a single-chain antibody (scFv) and characterized with respect to sensitivity in Western blot analyses and behavior in purification procedures using affinity chromatography. The p24 tag also proved to be a suitable alternative to the (Gly4Ser)3 linker commonly used to connect single-chain antibody variable regions derived from a heavy (VH) and light chain (VL). Binding of CB4-1 antibody to the p24 tag was not hampered when the tag was located internally in the protein sequence, and the specific antigen affinity of the scFv was only slightly reduced. All scFv variants were solubly expressed in Escherichia coli and could be purified from the periplasm. Our results highlight the p24 tag as a useful tool for purifying and detecting recombinantly expressed scFvs.
Structure-Function Analysis of the Bestrophin Family of Anion Channels (2003)

The bestrophins are a newly described family of anion channels unrelated in primary sequence to any previously characterized channel proteins. The human genome codes for four bestrophins, each of which confers a distinctive plasma membrane conductance on transfected 293 cells. Extracellular treatment with methanethiosulfonate ethyltrimethylammonium (MTSET) of a series of substitution mutants that eliminate one or more cysteines from human bestrophin1 demonstrates that cysteine 69 is the single endogenous cysteine responsible for MTSET inhibition of whole-cell current. Cysteines introduced between positions 78-99 and 223-226 are also accessible to external MTSET, with MTSET modification at positions 79, 80, 83, and 90 producing a 2-6-fold increase in whole-cell current. The latter set of four cysteine-substitution mutants define a region that appears to mediate allosteric control of channel activity. Mapping of transmembrane topography by insertion of N-linked glycosylation sites and tobacco etch virus protease cleavage sites provides evidence for cytosolic N and C termini and an unexpected transmembrane topography with at least three extracellular loops that include positions 60-63, 212-227, and 261-267. These experiments provide the first structural analysis of the bestrophin channel family.
Radiofrequency heating pathways for gold nanoparticles (2014)

This feature article reviews the thermal dissipation of nanoscopic gold under radiofrequency (RF) irradiation. It also presents previously unpublished data addressing obscure aspects of this phenomenon. While applications in biology motivated initial investigation of RF heating of gold nanoparticles, recent controversy concerning whether thermal effects can be attributed to nanoscopic gold highlight the need to understand the involved mechanism or mechanisms of heating. Both the nature of the particle and the nature of the RF field influence heating. Aspects of nanoparticle chemistry which may affect thermal dissipation include the hydrodynamic diameter of the particle, the oxidation state and related magnetism of the core, and the chemical nature of the ligand shell. Aspects of RF which may affect thermal dissipation include power, frequency and antenna designs that emphasize relative strength of magnetic or electric fields. These nanoparticle and RF properties are analysed in the context of three heating mechanisms proposed to explain gold nanoparticle heating in an RF field. This article also makes a critical analysis of the existing literature in the context of the nanoparticle preparations, RF structure, and suggested mechanisms in previously reported experiments.
Microheterogeneity of alpha<sub>1</sub>‐acid glycoprotein in the detection of intercurrent infection in systemic lupus erythematosus (1987)

We evaluated the clinical usefulness of determinations of alpha 1-acid glycoprotein microheterogeneity patterns in distinguishing patients who have active systemic lupus erythematosus (SLE) from those who have SLE with intercurrent infection. We used agarose affinity electrophoresis with concanavalin A (Con A) as a ligand. Results were expressed as reactivity coefficients (RC), which are the ratios of variants reactive with Con A to the variants not reactive with Con A. No significant differences were found between the mean RC (+/- SD) in healthy individuals (1.35 +/- 0.26) and that in patients with various degrees of SLE activity. In contrast, a significantly higher mean RC was found in sera from patients with intercurrent infection (2.70 +/- 0.76) compared with each of the other groups studied (P less than 0.001). An RC greater than 2.25 was found in none of 42 sera from patients without infection and in 15 of 18 sera from patients with infection (sensitivity 83%, specificity 100%). C-reactive protein (CRP) levels were also significantly higher in SLE patients with intercurrent infection than in patients with very active disease (P less than 0.05). Levels of CRP greater than 60 mg/liter were found in 3 of 42 SLE patients without infection and in 8 of 18 patients with infection (sensitivity 39%, specificity 93%). The results show that in SLE patients, the finding of a relative increase in Con A-bound serum alpha 1-acid glycoprotein is a more sensitive indicator of intercurrent infection than is the finding of increased levels of CRP.
Green emission and bandgap narrowing due to two-photon excitation in thin film CdS formed by spray pyrolysis (2001)

Thin (10 µm) film CdS on Pyrex® formed by spray pyrolysis is excited below the gap at 804 nm with 200 fs laser pulses at room temperature. Excitation intensities up to 250 GW cm-2 evoke green bandgap emission due to two-photon transitions. This two-photon photoluminescence does not show a red emission contribution in contrast to the single-photon excited emission, which is dominated by broad emission in the red spectral range. It is demonstrated that two-photon excitation causes photo-induced bandgap narrowing due to Debye screening. At 250 GW cm-2 bandgap narrowing of 47 meV is observed, which corresponds to an excited electron density of 1.6×1018 cm-3.
On-the-Fly Processing of Generalized Lumigraphs (2001)

We introduce a flexible and powerful concept for reconstructing arbitrary views from multiple source images on the fly. Our approach is based on a Lumigraph structure with per-pixel depth values, and generalizes the classical two-plane parameterized light fields and Lumigraphs. With our technique, it is possible to render arbitrary views of time-varying, non-diffuse scenes at interactive frame rates, and it allows using any kind of sensor that yields images with dense depth information. We demonstrate the flexibility and efficiency of our approach through various examples.
A synthetic analogue of Escherichia coli lipoprotein, tripalmitoyl pentapeptide, constitutes a potent immune adjuvant. (1986)

Lipoprotein from the outer membrane of Escherichia coli and other Enterobacteriaceae constitutes a potent B lymphocyte mitogen and polyclonal activator in various species. Tripalmitoyl pentapeptide (S-(2,3-bis-(palmitoyloxy)-(2RS)-propyl)-N-palmitoyl-(R)-cysteinyl -(S)-seryl-(S)-seryl-(S)-asparaginyl-(S)-alanine) is a synthetic analogue of the N-terminal part of lipoprotein and has, in all assays tested, a biologic activity similar to native lipoprotein. It also exhibits a strong adjuvant activity in vitro: In the presence of 3.3 to 33.3 micrograms/ml of tripalmitoyl pentapeptide, the stimulation of the primary antibody response toward underivatized sheep red blood cells (SRBC) and toward trinitrophenylated (TNP-) SRBC was markedly enhanced, as measured by a direct hemolytic plaque assay. At optimal mitogen- and antigen-doses, plaque formation was increased up to 100-fold, and at suboptimal doses (0.03 to 0.3 microgram/ml) a 10- to 60-fold increase of plaque numbers was achieved. In the presence of tripalmitoyl pentapeptide, the antigen-specific IgM response was increased about sevenfold and the IgG response was augmented about 10-fold, as measured by ELISA. Similarly, in the secondary in vitro response to TNP-SRBC, a 7 to 10-fold enhancement of the antibody titer was obtained in the presence of the adjuvant. The application of tripalmitoyl pentapeptide and antigen had to occur concurrently in order to achieve a strong adjuvant effect. Addition of tripalmitoyl pentapeptide to the cell cultures 1 day after or 1 day before antigen application had no significant positive effect, and in several instances a decrease in antibody production was found. Thus, tripalmitoyl pentapeptide, a well-characterized synthetic product available in major amounts, constitutes a potent immune adjuvant for potential animal and clinical use.