gebhart/patrepeval huggingface dataset:
Computer Supported Cooperative Work (CSCW) - State-of-the-Art und zukünftige Herausforderungen (2000)

Die informationstechnologische Unterstutzung der Gruppenarbeit steht etwa seit Mitte der achtziger Jahre im Blickpunkt der Forschung. Unter CSCW-Applikationen bzw. Groupware oder Collaborative Support Systems (CSS) werden Systeme verstanden, welche eine Computerunterstutzung kooperativen Arbeitens ermoglichen. Auf dieser Basis wurden in einer ersten Entwicklungsphase vornehmlich Applikationen entwickelt, welche nur bestimmte Teilaspekte der Gruppenarbeit unterstutzten. Durch die wachsende Bedeutung teamorientierter Managementkonzepte und die zunehmende Akzeptanz kollaborativer Technologien als geschaftskritische Anwendungen erwuchsen Losungen, welche diese isolierten Einzelapplikationen in CSCW-Suites zusammenfassten und weiterentwickelten. An der Schwelle zur Knowledge-based Economy stehen CSCW-Konzepte und -Applikationen jedoch vor einer neuen Herausforderung. Einerseits weitet sich der Benutzerkreis auf unternehmensweite oder gar unternehmensubergreifende Communities aus, andererseits erfolgt eine zunehmende Durchdringung und Integration mit anderen geschaftskritischen Anwendungen wie beispielsweise Transaktions- oder Managementinformationssystemen. Ausgehend von begrifflichen Grundlagen beschreibt der vorliegende Beitrag zunachst den State-of-the-Art kollaborativer Anwendungen. Zu diesem Zweck werden aufbauend auf bestehende Systematisierungsansatze CSCW-Anwendungskategorien beschrieben. Angesichts der steigenden Bedeutung von CSCW im Hinblick auf die Vernetzung des Geschaftslebens werden anschliesend zukunftige Herausforderungen skizziert und in ein Referenzmodell fur E-Community/ Collaboration eingeordnet.
TOTAL PANCREATECTOMY IN THE PIG FOR ISLET TRANSPLANTATION TECHNICAL ALTERNATIVES (1991)

Pigs appear to be a suitable biological and logistical animal donor of islets for xenotransplantation in human diabetic type I recipients. To improve the islet isolation technique in this species, to evaluate the islet function in vivo, and to assess the toxic effects of various immunosuppressive regiments on transplanted islets will necessitate a model of the pancreatectomized pig suitable for islet autotransplantation. We describe three techniques of total pancreatectomy in pigs. The first removed the pancreas in order to study postoperative management and pig survival; no attempt was made to preserve the pancreas for islet isolation. The second consisted of a pancreatectomy in a surviving pig, with careful preservation of the whole pancreas for subsequent islet isolation. The third was rapid en bloc procurement of the pancreas and duodenum, to obtain a pancreas solely for the purpose of islet isolation. We conclude that pigs tolerate and survive a total pancreatectomy--they are suitable animals for islet isolation and possible autotransplantation. The result of islet isolation does not appear related to the pancreas procurement technique; however, the islet yield must be improved before autotransplantation can be functionally successful.
A 65 nm-node CMOS technology with highly reliable triple gate oxide suitable for power-considered system-on-a-chip (2004)

We have developed 65 nm-node CMOS technology for general-purpose system-on-a-chip (SoC), in which both standby and active power reductions are strongly required. With highly reliable triple gate oxide (1.3 nm, 1.6 nm and 3.2 nm) using low damage process, an average standby current can be reduced to one-fifth compared with conventional case. Gate pre-doping and RTA conditions were optimized to maintain on-current even with the supply voltage of 0.9 V. High-speed (HS) transistors show on-current of 680 /spl mu/A//spl mu/m for nFET and 240 /spl mu/A//spl mu/m for pFET with I/sub G/ of 13 nA//spl mu/m and I/sub OFF/ of 30 nA//spl mu/m. Low-gate-leakage (LGL) transistors show on-current of 490 /spl mu/A//spl mu/m for nFET and 175 /spl mu/A//spl mu/m for pFET with I/sub G/ of 0.8 nA//spl mu/m and I/sub OFF/ of 3 nA//spl mu/m. Gate oxide of all the above transistors exhibit tight TDDB distributions.
Fungal Degradation of Triacrylonitrile (1981)

Journal Article Fungal Degradation of Triacrylonitrile Get access Yasuhisa Asano, Yasuhisa Asano Department of Agricultural Chemistry and Kyoto University, Kyoto 606, Japan Search for other works by this author on: Oxford Academic Google Scholar Shinji Ando, Shinji Ando Department of Agricultural Chemistry and Kyoto University, Kyoto 606, Japan Search for other works by this author on: Oxford Academic Google Scholar Yoshiki Tani, Yoshiki Tani Department of Agricultural Chemistry and Kyoto University, Kyoto 606, Japan Search for other works by this author on: Oxford Academic Google Scholar Hideaki Yamada, Hideaki Yamada Department of Agricultural Chemistry and Kyoto University, Kyoto 606, Japan Search for other works by this author on: Oxford Academic Google Scholar Tamio Ueno Tamio Ueno Pesticide Research Institute, Kyoto University, Kyoto 606, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 45, Issue 1, 1 January 1981, Pages 57–62, https://doi.org/10.1080/00021369.1981.10864495 Published: 01 January 1981 Article history Received: 08 April 1980 Published: 01 January 1981
Metastasis suppressor genes: a role for raf kinase inhibitor protein (RKIP) (2004)

The metastatic cascade is a complicated process that involves many steps from gain of the metastatic phenotype in the primary tumor cells through establishment of macroscopic tumor at the distant target organ. A group of genes, termed metastasis suppressor genes (MSG), encode for proteins that inhibit various steps of the metastatic cascade. Accordingly, loss of MSG promotes the metastatic phenotype. Although several MSG have been identified, the mechanisms through which they enhance metastasis are not clearly defined. Gene array analysis of a low metastatic LNCaP prostate cancer cell line compared to its highly metastatic derivative C4-2B prostate cancer cell line revealed decreased expression of raf kinase inhibitor protein (RKIP) in the C4-2B cell line. RKIP blocks the activation of several signaling pathways including MEK, G-proteins and NFkappaB. Immunohistochemical analysis of prostate cancer primary tumors and metastases revealed that RKIP protein expression was decreased in metastases. Restoration of RKIP expression in the C4-2B cell line diminished metastasis in a murine model. These results demonstrate that RKIP is a MSG. Loss of RKIP enhanced both angiogenesis and vascular invasion, and protected against apoptosis. These findings suggest that targeting the RKIP pathway may diminish the metastatic cascade. However, challenges exist as to the best method to target RKIP expression. Restoration of RKIP expression in all cancer cells in vivo is challenging. A plausible strategy is to use small molecules that target proteins in signaling pathways that are dysregulated due to loss of RKIP.
Global Identification of Variability Factors and Its Application to the Statistical Worst-Case Model Generation (2006)

A novel methodology is presented to generate the worst-case model including extraction of its compact model parameters. This method enables physically accurate worst-case prediction in the early stage of device development concurrently. It is found through the intensive TEG analysis and TCAD simulation that correlations between process factors have a significant impact on the worst-case corner estimation. A new extraction method of compact model parameters based on error propagation analysis is developed to consider correlations between parameters
Performance of Low Density Parity Check Code Applied in WiBro System (2007)

In Korea, a new broadband wireless access system-High speed Portable Internet (WiBro, Wireless Broadband) is devised to provide high data-rate Internet service. WiBro is considered as the subset of consolidated version of IEEE802. 16c and aims to provide high-speed packet service even when mobile speed comes to 120km/h. This paper presents a brief introduction to the key features of WiBro' s physical layer. Then an advanced channel coding technology- adopted in IEEE802. 16e- structured LDPC is applied to WiBro. The performance of structured LDPC coded WiBro system with different modulation level over AWGN and multi-path channel is simulated. Comparison between structured LDPC and Convolution Turbo Code (CTC) defined in the same proposal are discussed. Simulation results show that the two codes have similar performance when the code rate is low; but LDPC shown better performance than CTC in high code rate, especially at high modulation level.
Deposition of colloidal sintering-aid particles on silicon nitride (1993)

The deposition of alumina (Al2O3) and yttria (Y2O3) particles on silicon nitride (Si3N4) by electrostatic and electrosteric interactions was studied using acoustophoretic measurements. The characteristics of Si3N4, Al2O3' and Y2O3 powders in an aqueous environment were studied by measuring the electrokinetic sonic amplitude (ESA), and appropriate conditions for deposition by adsorption were identified. The deposition of Al2O3' Y2O3, and Y(NO3)3 on Si3N4 particles was conducted at different pH values where these chemically dissimilar particles exhibit electrical charges of opposite sign. The deposition studies indicated that the particle size has a strong effect on the amount of coating on Si3N4 particles. The presence of polyacrylic acid as an electrosteric stabilizer for Si3N4 had no measurable effect on Al2O3 adsorption. The shift of the isoelectric point of Si3N4 with Al2O3 showed that the total quantity of Al2O3 adsorbed on Si3N4 reached a maximum at approximately 75% coverage of the total surface area of Si3N4. Bremsstrahlungexcited Auger electron spectroscopy (AES) results showed that the as-received Si3N4 powder has a native oxide film of 8.9 Å. The presence and relative differences in the surface composition of coated particles were established using X-ray photoelectron spectroscopy (XPS).
A low-cost, high-density mounting system for computer clusters (2001)

As the number of the processing units in a cluster computing system increases, what once were inconsequential details become major engineering concerns. Space, power distribution, and heat dissipation each demand attention for such clusters. We describe a simple rack mounting system that serves as a low-cost solution for clusters with fifty or more machines. Four motherboards of the same form factor are linked together with threaded rods and spacers and hang from inexpensive shelf brackets. This approach has enabled us to mount forty-eight motherboards and additional support hardware on a 6.5ft mobile rack with a 27in x 32in footprint for a fraction of the cost of traditional computer rack equipment or standard cases. In addition, the sharing of power supplies by eight motherboards has dramatically reduced complexity of our cluster. Efficient heat dissipation is demonstrated by thermal imaging.
Principles of Vaccine Potency Assays (2018)

Compared with biologics, vaccine potency assays represent a special challenge due to their unique compositions, multivalency, long life cycles and global distribution. Historically, vaccines were released using in vivo potency assays requiring immunization of dozens of animals. Modern vaccines use a variety of newer analytical tools including biochemical, cell-based and immunochemical methods to measure potency. The choice of analytics largely depends on the mechanism of action and ability to ensure lot-to-lot consistency. Live vaccines often require cell-based assays to ensure infectivity, whereas recombinant vaccine potency can be reliably monitored with immunoassays. Several case studies are presented to demonstrate the relationship between mechanism of action and potency assay. A high-level decision tree is presented to assist with assay selection.
A 3D Outdoor Scene Scanner Based on a Night-Vision Range-Gated Active Imaging System (2006)

We present a 3D outdoor scene scanner for the acquisition of kilometers-deep scenes in night conditions. Its imaging system is based on a compact and low-cost pulsed laser illuminator and a light-intensifier equipped CCD camera. By precisely synchronizing both the illuminator and the camera shutter, it is possible to acquire "slices" of the scene at specific known distances. We show that even with large laser pulses and without megahertz-capable electronics, the third dimension can be recovered for the whole range of the scene by processing only two images acquired in specific conditions. As the pixel intensities of the images produced by active imaging systems vary with the square of the range, and due to the limited dynamics of image sensors, scanning long-range scenes with shorter "slices" allows the camera gain to be adjusted with respect to the range and the accuracy to be enhanced. The imaging system as well as the different image processing steps are detailed in this paper and an example of typical results is given.
Overexpression of the vimentin gene in transgenic mice inhibits normal lens cell differentiation. (1989)

To investigate the role of the intermediate filament protein vimentin in the normal differentiation and morphogenesis of the eye lens fiber cells, we generated transgenic mice bearing multiple copies of the chicken vimentin gene. In most cases, the vimentin transgene was overexpressed in the lenses of these animals, reaching up to 10 times the endogenous levels. This high expression of vimentin interfered very strongly with the normal differentiation of the lens fibers. The normal fiber cell denucleation and elongation processes were impaired and the animals developed pronounced cataracts, followed by extensive lens degeneration. The age of appearance and extent of these abnormalities in the different transgenic lines were directly related to the vimentin level. Electron microscopic analysis revealed that the accumulated transgenic protein forms normal intermediate filaments.
The Influence of Angiotensin II Antagonist Postischemic Acute Renal Failure (1981)

In 34 dogs the effect of a 90-min period of warm ischemia on renal perfusion and function was studied with and without (Sar1, Ile8) angiotensin II treatment. In the first 3 h after the release of renal arterial occlusion, a significant influence of the angiotensin II antagonist on changes in postischemic vascular resistance, intrarenal hemodynamics and renal function could be demonstrated, all being well preserved in the treated group.
A Meta-Analysis of the Impact of Monensin in Lactating Dairy Cattle. Part 3. Health and Reproduction (2008)

A meta-analysis of the impact of monensin on health and reproductive outcomes in dairy cattle was conducted. A total of 16 papers were identified with sufficient data and quality to evaluate health and reproductive outcomes for monensin. The available trials provided approximately 9,500 cows with sufficient data for analysis. This provided good statistical power to examine the effects of monensin on health and reproduction. Over all the trials analyzed, monensin decreased the risk of ketosis [relative risk (RR) = 0.75], displaced abomasums (RR = 0.75), and mastitis (RR = 0.91). No significant effects of monensin were found for milk fever, lameness, dystocia, retained placenta, or metritis. Monensin had no effect on first-service conception risk (RR = 0.97) or days to pregnancy (hazard ratio = 0.93). However, the impact of monensin on dystocia, retained placenta, and metritis was heterogeneous for all 3 outcome measures and random effect models were utilized. Causes of the heterogeneity were explored with meta-regression. Days of treatment with monensin before calving increased the risk of dystocia. Delivery method of monensin influenced the incidence of retained placenta and metritis, with risk being lower with controlled release capsule treatment compared with delivery in either topdress or in a total mixed ration. Days of treatment before calving also influenced retained placenta with an increase in risk with more days treated before calving. Improvements in ketosis, displaced abomasums, and mastitis with monensin were achieved. Exposure to prolonged treatment in the dry period with monensin may increase the risk of dystocia and retained placenta.
Bayesian Aggregation For Hierarchical Genre Classification. (2007)

[TODO] Add abstract here.
Is <sup>18</sup>F-FDG PET/CT Useful for the Early Prediction of Histopathologic Response to Neoadjuvant Erlotinib in Patients with Non–Small Cell Lung Cancer? (2010)

The results of this study suggest that early during the course of epidermal growth factor receptor tyrosine kinase inhibitor therapy, (18)F-FDG PET/CT can predict response to erlotinib treatment in patients with non-small cell lung cancer.
Correlates of Immune Protection from Tuberculosis (2007)

Due to the failure of chemotherapy and the only available vaccine, BCG, to control tuberculosis (TB) disease, there is an urgent need to develop new vaccines and therapeutics. The identification of correlates of immune protection or "biomarkers" will facilitate the rational design of vaccines and drugs for the prevention and clearance of TB infection. Although it is known that IFN-gamma is essential for protective immunity, animal and human studies have found that IFN-gamma alone is not sufficient for the prevention of TB disease. There is evidence that IL-23, a recently described member of the IL-12 family of cytokines, is important in the immuno-pathogenesis of TB. There is also evidence that regulatory T cells (Treg) are present in TB disease and that Treg may suppress effector T cell responses. In the last five years, clinical studies have been able to use Mycobacterium tuberculosis specific antigens, such as ESAT-6, to focus on recently infected, healthy contacts of TB patients in endemic countries. Advances in techniques such as multi-parameter flow cytometry and DNA microarray analysis will enable us to study these cohorts in great detail and facilitate the identification of immune correlates for the rational design of drugs and vaccines for the treatment and prevention of TB.
The necessity of an intact polyene for the biological isomerization of vitamin A (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe necessity of an intact polyene for the biological isomerization of vitamin AWing C. Law, Robert R. Rando, Stefano. Canonica, Fadila. Derguini, and Koji. NakanishiCite this: J. Am. Chem. Soc. 1988, 110, 17, 5915–5917Publication Date (Print):August 1, 1988Publication History Published online1 May 2002Published inissue 1 August 1988https://pubs.acs.org/doi/10.1021/ja00225a062https://doi.org/10.1021/ja00225a062research-articleACS PublicationsRequest reuse permissionsArticle Views159Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Influence of dialysis modality on renal transplant complications and outcomes (2009)

The influence of PD and HD on complications after renal transplant at 1 year and 5 years and graft survival rates was similar, and therefore, either HD or PD can be chosen as the pretransplant dialysis modality. However, patients in the PD group had a reduced incidence of hepatitis virus infection, suggesting that PD may have certain advantages over HD as a preoperative substitution therapy for renal transplantation.
ChemInform Abstract: Coupling Reaction of Alkenes with α‐Bromo Carboxylic Acid Derivatives Using Nickel Boride and Borohydride Exchange Resin in Methanol. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Rapid detection of urinary tract infection evaluation of flow cytometry (2006)

Results obtained by the BACSYS-40i can be reported after a few minutes. Urine samples from all 57 patients with predominant clinical signs and in addition growth of bacteria isolated from urine and known as pathogens of UTI had positive results with the analyzer (100%) for elevated bacteria and leukocyte counts. Furthermore, all patients without symptoms for UTI were negative after analysis with the BACSYS-40i (44/44; 100%).
Detection of N-myc oncogene expression in human neuroblastoma by in situ hybridization and blot analysis: relationship to clinical outcome. (1986)

We studied N-myc oncogene expression in 13 human neuroectodermal tumors and one teratoma by in situ hybridization. In four of six neuroblastomas, there was increased N-myc expression (15 to 49% of the cells). Many of the primitive neuroblastic cells had an increase of N-myc RNA not observed in the larger, more differentiated cells. Two neuroblastomas matured to ganglioneuromas; no biopsies performed during this progression expressed increased N-myc RNA. Three ganglioneuroblastomas, two tumors presenting as ganglioneuromas, a cerebral neuroectodermal tumor, a neurofibrosarcoma, and the teratoma did not have increased N-myc expression. The data obtained by in situ hybridization correlated well with data obtained by blot analysis. Neuroblastomas/ganglioneuroblastomas with a favorable course did not have appreciable elevation of N-myc expression over 10 to 77 mo of follow-up; thus N-myc may not be involved in the maintenance of the neoplastic state. However, such tumors with a fatal outcome 2 to 14 mo after diagnosis usually had elevated N-myc expression. These findings suggest a relationship between elevated levels of N-myc RNA and poor prognosis.
The consumption of fentanyl is increased in rats with nociceptive but not with neuropathic pain (1995)

The question whether opioids relieve neuropathic pain remains a controversial issue. Experimental as well as clinical studies report contradictory results. This study investigated the consumption of fentanyl, a short-acting opioid, in rats with neuropathic pain, induced by partial sciatic nerve injury. The experiment consisted of a drug choice procedure in which the animals could choose between a solution containing 0.008 mg/ml of fentanyl and a highly palatable sweet solution. It was reasoned that if opioids have an analgesic effect in neuropathic pain, this will reinforce the intake of fentanyl more so in rats with neuropathic pain than in pain-free controls. This protocol was previously already used by Colpaert et al. (1982) in a rat model of chronic pain of nociceptive origin, namely polyarthritis. No significant differences were found in the relative oral intake of the fentanyl solution in mononeuropathic and pain-free control rats. In contrast, rats with nociceptive pain, adjuvant monoarthritis, drank significantly more of the fentanyl solution than did control rats. These data give experimental support for the clinical findings that opioids have a poor analgesic effect in neuropathic pain.