gebhart/patrepeval huggingface dataset:
Early Neoplastic Progression Is Complement Independent (2004)

Infiltration of leukocytes into premalignant tissue is a common feature of many epithelial neoplasms and is thought to contribute to cancer development. However, the molecular and cellular regulatory mechanisms underlying activation of innate host responses to enhanced neoplastic cell proliferation are largely unknown. Considering the importance of the complement system in regulating inflammation during acute pathologic tissue remodeling, we examined the functional significance of complement component 3 (C3) as a regulator of inflammatory cell infiltration and activation during malignant progression by using a transgenic mouse model of multistage epithelial carcinogenesis, e.g., HPV16 mice. Whereas abundant deposition of C3 is a characteristic feature of premalignant hyperplasias and dysplasias coincident with leukocyte infiltration in neoplastic tissue, genetic elimination of C3 neither affects inflammatory cell recruitment toward neoplastic skin nor impacts responding pathways downstream of inflammatory cell activation, e.g., keratinocyte hyperproliferation or angiogenesis. Taken together, these data suggest that complement-independent pathways are critical for leukocyte recruitment into neoplastic tissue and leukocyte-mediated potentiation of tumorigenesis.
ANÁLISIS SOBRE EL PENSAMIENTO CRÍTICO DE SÁNCHEZ VÁZQUEZ. CONCLUYÓ COLOQUIO INTERNACIONAL (2015)

PARA CONMEMORAR EL CENTENARIO DEL NATALICIO DE UNO DE LOS MAS IMPORTANTES FILOSOFOS Y PENSA­DORES DE ESTA CASA DE ESTUDIOS, LA FACULTAD DE FILOSOFIA Y LETRAS (FFL) CULMINO EL COLOQUIO INTERNACIONAL ADOLFO SANCHEZ VAZQUEZ, A CIEN ANOS DE SU NACIMIENTO. EN LA MESA SOCIALISMO, ELVIRA CONCHEIRO, DEL CENTRO DE INVESTIGACIONES INTERDIS­CIPLINARIAS EN CIENCIAS Y HUMANIDADES (CEIICH); ROLANDO CORDERA CAMPOS Y ENRIQUE SEMO, PROFESOR EMERITO E INVESTIGADOR EMERITO DE LA FACULTAD DE ECONOMIA, RES­PECTIVAMENTE, Y ARMANDO BARTRA, DE LA UNIVERSIDAD AUTONOMA METROPOLITANA (UAM), UNIDAD XOCHIMILCO, ANALIZARON EL PENSAMIENTO CRITICO DEL FILOSOFO DEL EXILIO ESPANOL. EN LA MESA ETICA Y POLITICA PARTICIPARON JULIANA GONZALEZ, PROFESORA EMERITA DE LA FFL, Y VICTOR FLORES OLEA, DEL CEIICH, QUIENES ABORDARON LOS CONCEPTOS SOBRE MARXISMO DE SANCHEZ VAZQUEZ, ASI COMO JOSE WOLDENBERG, PROFESOR DE LA FACULTAD DE CIENCIAS POLITICAS Y SOCIALES, QUIEN MENCIONO LOS RAZONAMIENTOS DEL TRANSTERRADO SOBRE ETICA Y POLITICA. EN LA MESA MARXISMOS E HISTORIA, EL EXRECTOR DE LA UNAM E INVESTIGADOR EMERITO PABLO GONZALEZ CASANOVA OFRECIO LA PONENCIA LA HISTORIA Y EL MARXISMO COMO CIENCIA Y COMO TEORIA CRITICA; SERGIO LOMELI, PROFESOR DE LA FFL, HABLO DE ALGUNAS CONSIDERACIONES  A PROPOSITO DE LA FILOSOFIA DE LA HISTORIA DE SANCHEZ VAZQUEZ Y DEL PROBLEMA DE LA BUSQUEDA DEL SENTIDO EN LOS HECHOS, Y PEDRO JOEL REYES, PROFESOR DEL COLEGIO DE FILOSOFIA, SE REFIRIO TAMBIEN A LA FILOSOFIA DE LA HISTORIA EN LA OBRA DEL HOMENAJEADO, LA QUE CONTRIBUYO A CONSIDERAR, EN EL AMBITO ACADEMICO, LA IMPORTANCIA TEORICA DEL MARXISMO. SU OBRA, CONCLUYO, MUESTRA COMO ESTE ULTIMO COADYUVO, DE MANERA ORIGINAL, A LOS NUEVOS CAMPOS DE ESTUDIO DE LA FILOSOFIA.
A Large‐scale Mutagenesis Screen to Identify Seizure‐resistant Zebrafish (2007)

Zebrafish offers a powerful tool for the identification and study of a genetic basis for seizure resistance.
Fresnel zone binning: Application to 3D seismic fold and coverage assessments (2009)

In a parallel article submitted to GEOPHYSICS, I have outlined the derivation of size and shape for Fresnel zones as a function of offset and velocity gradient. The fundamental conclusion of this analysis is that the Fresnel zone computed using a zero-offset assumption and constant velocity is a poor representation of the “area of influence” of the Fresnel zone in a practical sense. The relevance and practical application of these Fresnel zone sizes is described in terms of current “binning” in 3D seismic (particularly marine 3D), and the Fresnel zone analysis leads to an alternate method of assessing adequate coverage in a 3D survey.
Growth, structural and optical properties of 12%‐deuterated KDP crystals (2013)

K(D 0.12 H 0.88 ) 2 PO 4 crystals were chosen to be used for quadratic nonlinear medium of wideband frequency doubling at 1 μm. A key limitation on this application is that little information can be found in the previous reports. In this work, growth as well as structural and optical properties of this crystal were investigated in detail. Experimental results in comparison with KDP indicate that lattice parameter along a‐axis changes much more than lattice parameter c and infra‐red absorption edge shift by 0.08 μm accompanied with increasing of transmittance in the whole region. With the introduction of deuterium atom, peak of ν 1 (PO4) shifts to lower wave number and transverse stimulated Raman scattering was effectively suppressed. Extra‐ordinary and ordinary indices were also measured as function of wavelength. Good crystalline perfection and great performance of damage threshold also indicate that 12%‐DKDP is an appropriate choice in the application of wideband frequency doubling at 1 μm.
Diversity of rotavirus serotypes in Mexican infants with gastroenteritis (1990)

One hundred thirty-two stool specimens from infants with rotavirus gastroenteritis hospitalized in two Mexican cities (Mexico City and Mérida) were examined by serotype- and subgroup-specific enzyme immunoassays. Among them, 38 (29%) were serotype 1, 15 (11%) were serotype 2, 13 (10%) were serotype 3, 22 (17%) were serotype 4, none was serotype 5 or 6, and 44 (33%) could not be serotyped. By subgrouping, 121 specimens were characterized as follows: 24 (18%) were subgroup 1, 97 (74%) were subgroup 2, and none had both subgroup specificities. While serotype 1 rotavirus predominated in the Mexico City area for 4 consecutive years (1984 to 1987), serotype 4 predominated in Mérida during the single epidemic season studied (1985). These data demonstrate that all four primary human rotavirus serotypes circulated in Mexico, with serotype 1 being the most prevalent. The seroneutralization responses of 14 of the 22 patients infected with serotype 4 strains had been previously studied. Of these 14 infants, 11 appeared to have primary infections, as indicated by absence of neutralizing antibodies in the acute-phase sera and their young age (8 months on average) at the time of illness. Seven patients seroresponded to serotypes 1 and 4; two seroresponded to serotypes 1, 3, and 4; three seroresponded to serotype 1; and two had low-level seroresponses to serotype 3 or 4. These data indicate that heterotypic neutralizing antibody responses occur frequently following infection with serotype 4 rotaviruses.
Anti Bovine Rotavirus Polypeptide from Buttermilk (2002)

バター製造時の副産物であるバターミルクをブロメライン消化することにより得られたバターミルク加水分解物 (HBM) に耐熱性の抗ウシロタウイルス活性を認めた. 活性部位をDEAEおよびゲル濾過 (Superdex 75) にて部分精製を行い, 抗ロタウイルス活性を有する4つの画分HBM-0.2-A, HBM-0.2-B, HBM-0.4-AおよびHBM-0.4-Bを得た. 各画分のED50 (mg/ml ) はHBM-0.2-A, HBM-0.2-B, HBM-0.4-AおよびHBM-0.4-Bの順にそれぞれ0.16, 1.75, 0.14, 3.25であった. 各フラクションをSDS-PAGEにより分析した結果, HBM-0.2-A, HBM-0.2-B, HBM-0.4-AおよびHBM-0.4-Bの順に分子量14～30, 14～21, 14～35および14～21kDaに強いバンドが検出された. ウエスタンブロット後に小麦胚芽レクチン (WGA) で検出したところ, 活性の高かったHBM-0.2-AとHBM-0.4-Aは同様のパターンを示し, 分子量20～25, 30～35および70～100kDaの3つの糖ポリペプチドから成るフラクションであることが認められた. シアル酸含量が高かったHBM-0.2-BおよびHBM-0.4-Bは抗ロタウイルス活性が弱く, WGAでも検出されなかったことから, 抗ロタウイルス活性はシアル酸の結合部位を中心とした糖鎖構造に依存していることが推測された.
A Nyquist Rate SAR ADC Employing Incremental Sigma Delta DAC Achieving Peak SFDR = 107 dB at 80 kS/s (2017)

This paper introduces an architecture and design for high-resolution high-linearity Nyquist rate successive approximation register (SAR) analog-to-digital converters (ADCs) using a hybrid capacitive and incremental ΣA digital-to-analog converter (DAC). The proposed architecture benefits from an intrinsically linear 1.5-bit ΣA DAC to resolve the fine bits of the SAR ADC after a coarse conversion phase with a monotonically switched capacitive DAC (CDAC). The achieved linearity relies neither on a highly matched CDAC nor on any dynamic linearization techniques but on a single calibration of the coarse CDAC using the available ΣA DAC at startup. Therefore, the CDAC can be sized solely upon noise requirements. The SAR ADC employs two parallel dynamic comparators for improved power efficiency. A prototype was fabricated in a 40-nm CMOS, with power supplies of 1.1 and 2.5 V. It occupies an active area of only 0.074 mm2. The prototype achieves a measured peak spurious free dynamic range (SFDR) of 107 dB and peak signal to noise and distortion ratio (SNDR) of 84.8 dB dB at 80kS/s Nyquist rate operation with 5.3-kHz input. The measured performance at the Nyquist frequency, limited by signal source quality, is SFDR = 99.5 dB and SNDR = 83.5 dB. The core power consumption is 110 μW. In oversampling mode, the ADC achieves an SNDR above 90 dB over a 5-kHz bandwidth.
RF-based 3D skeletons (2018)

This paper introduces RF-Pose3D, the first system that infers 3D human skeletons from RF signals. It requires no sensors on the body, and works with multiple people and across walls and occlusions. Further, it generates dynamic skeletons that follow the people as they move, walk or sit. As such, RF-Pose3D provides a significant leap in RF-based sensing and enables new applications in gaming, healthcare, and smart homes.
A novel technique to calculate the bandwidth of rectangular microstrip antenna elements with thick substrates (1996)

Existing methods to compute the bandwidth of probe-fed rectangular microstrip antenna elements are inaccurate for the range of substrate thicknesses considered for this research. When 0.0815λ0 < h (λ0 is the free-space wavelength and h is the substrate thickness) the effect of surface waves is predominant and must be taken into account. A novel closed-form expression based on the cavity model and the exact Green's function for a grounded dielectric slab has been developed to compute the bandwidth of rectangular microstrip antenna elements, taking into account both the power radiated in space waves and the power radiated in surface waves. This method is original, simple, and easily included in a CAD system. The calculated results are in good agreement with measurements. © 1996 John Wiley & Sons, Inc.
An Algorithm for Synthesis of Reversible Logic Circuits (2006)

Reversible logic finds many applications, especially in the area of quantum computing. A completely specified n-input, n-output Boolean function is called reversible if it maps each input assignment to a unique output assignment and vice versa. Logic synthesis for reversible functions differs substantially from traditional logic synthesis and is currently an active area of research. The authors present an algorithm and tool for the synthesis of reversible functions. The algorithm uses the positive-polarity Reed-Muller expansion of a reversible function to synthesize the function as a network of Toffoli gates. At each stage, candidate factors, which represent subexpressions common between the Reed-Muller expansions of multiple outputs, are explored in the order of their attractiveness. The algorithm utilizes a priority-based search tree, and heuristics are used to rapidly prune the search space. The synthesis algorithm currently targets the generalized n-bit Toffoli gate library. However, other algorithms exist that can convert an n-bit Toffoli gate into a cascade of smaller Toffoli gates. Experimental results indicate that the authors' algorithm quickly synthesizes circuits when tested on the set of all reversible functions of three variables. Furthermore, it is able to quickly synthesize all four-variable and most five-variable reversible functions that were in the test suite. The authors also present results for some benchmark functions widely discussed in literature and some new benchmarks that the authors have developed. The algorithm is shown to synthesize many, but not all, randomly generated reversible functions of as many as 16 variables with a maximum gate count of 25
Nesprin-1 and -2 are involved in the pathogenesis of Emery–Dreifuss muscular dystrophy and are critical for nuclear envelope integrity (2007)

Emery-Dreifuss muscular dystrophy (EDMD) is a heterogeneous late-onset disease involving skeletal muscle wasting and heart defects caused, in a minority of cases, by mutations in either of two genes encoding the inner nuclear membrane (INM) proteins, emerin and lamins A/C. Nesprin-1 and -2 are multi-isomeric, spectrin-repeat proteins that bind both emerin and lamins A/C and form a network in muscle linking the nucleoskeleton to the INM, the outer nuclear membrane, membraneous organelles, the sarcomere and the actin cytoskeleton. Thus, disruptions in nesprin/lamin/emerin interactions might play a role in the muscle-specific pathogenesis of EDMD. Screening for DNA variations in the genes encoding nesprin-1 (SYNE1) and nesprin-2 (SYNE2) in 190 probands with EDMD or EDMD-like phenotypes identified four heterozygous missense mutations. Fibroblasts from these patients exhibited nuclear morphology defects and specific patterns of emerin and SUN2 mislocalization. In addition, diminished nuclear envelope localization of nesprins and impaired nesprin/emerin/lamin binding interactions were common features of all EDMD patient fibroblasts. siRNA knockdown of nesprin-1 or -2 in normal fibroblasts reproduced the nuclear morphological changes and mislocalization of emerin and SUN2 observed in patient fibroblasts. Taken together, these data suggest that EDMD may be caused, in part, by uncoupling of the nucleoskeleton and cytoskeleton because of perturbed nesprin/emerin/lamin interactions.
Inhibitory Effects of Super Reductive Water on Plant Pathogenic Fungi (2002)

The antifungal activity of super reductive water (SRW) against plant pathogenic fungi was examined to extend its application to integrated pest management (IPM) for plant diseases. Diluted solutions (<TEX>$\times$</TEX>1/10, <TEX>$\times$</TEX>1/25, and <TEX>$\times$</TEX>1/50) of SRW inhibited fungal growth of kiwifruit soft rot pathogen, Diaporthe actinidiae, in a concentration dependent manner, When kiwifruits were inoculated on wounds with mycelium blocks, stock and diluted solutions successfully inhibited the disease development. In addition to the high pH of the SRW, fungistatic activity was also considered as the cause of the antifungal effect against the pathogen. Whereas conidial germination of Magnaporthe grisea was not affected by the diluted SRW solutions, appressorium formation was significantly inhibited in a concentration dependent manner, With little harmfulness to human health and environment SRW could be used to control plant pathogenic fungi, particularly appressorium-forming fungal pathogens.
Multi-agent Diverse Generative Adversarial Networks (2018)

We propose MAD-GAN, an intuitive generalization to the Generative Adversarial Networks (GANs) and its conditional variants to address the well known problem of mode collapse. First, MAD-GAN is a multi-agent GAN architecture incorporating multiple generators and one discriminator. Second, to enforce that different generators capture diverse high probability modes, the discriminator of MAD-GAN is designed such that along with finding the real and fake samples, it is also required to identify the generator that generated the given fake sample. Intuitively, to succeed in this task, the discriminator must learn to push different generators towards different identifiable modes. We perform extensive experiments on synthetic and real datasets and compare MAD-GAN with different variants of GAN. We show high quality diverse sample generations for challenging tasks such as image-to-image translation and face generation. In addition, we also show that MAD-GAN is able to disentangle different modalities when trained using highly challenging diverse-class dataset (e.g. dataset with images of forests, icebergs, and bedrooms). In the end, we show its efficacy on the unsupervised feature representation task.
Neuronal and microglial involvement in beta-amyloid protein deposition in Alzheimer's disease. (1990)

This study was undertaken to localize amyloid precursor protein (APP) and to determine how APP might be released and proteolyzed to yield the beta-amyloid protein deposits found in senile plaques in the brains of Alzheimer's disease patients. We found that antibodies to recombinantly expressed APP labeled many normal neurons and neurites. In addition, dystrophic neurites in different types of senile plaques and degenerating neurons in the temporal cortex and hippocampus of Alzheimer's disease patients were immunostained. We also detected small clusters of dystrophic APP immunoreactive neurites that were not associated with beta-amyloid protein deposits. Microglia was involved in different types of senile plaques and often were associated closely with APP immunoreactive neurites and neurons. The greatest concurrence of APP immunoreactivity and reactive microglia was seen in the subiculum and area CA1, regions with a high density of congophilic plaques and subject to intense Alzheimer's pathology. Our findings suggest that neuronally derived APP is the source for senile plaque beta-amyloid protein, while microglia may act as processing cells.
Arbaclofen Placarbil Decreases Postprandial Reflux in Patients With Gastroesophageal Reflux Disease (2009)

AP decreased reflux and associated symptoms with good tolerability in patients with GERD.
Melanoma-Specific Antibodies Produced in Monkeys by Immunization With Human Melanoma Cell Lines2 (1973)

Monkeys immunized with 2 tissue-culture cell lines, derived from human melanomas, produced antibodies which appeared to be specific for melanoma antigen(s). The antisera, after absorption with human erythrocytes, normal peripheral blood leukocytes, and HeLa cells, failed to react with normal human fibroblasts and lymphocytes or with nonmelanoma malignant cell lines but gave strong reactivity by cytotoxicity and mixed agglutination with 4 melanoma celilines.
Main-chain second-order nonlinear optical polymers: random incorporation of amino-sulfone chromophores (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMain-chain second-order nonlinear optical polymers: random incorporation of amino-sulfone chromophoresChengzeng Xu, Bo Wu, Mark W. Becker, Larry R. Dalton, Peter M. Ranon, Yongqiang Shi, and William H. SteierCite this: Chem. Mater. 1993, 5, 10, 1439–1444Publication Date (Print):October 1, 1993Publication History Published online1 May 2002Published inissue 1 October 1993https://pubs.acs.org/doi/10.1021/cm00034a013https://doi.org/10.1021/cm00034a013research-articleACS PublicationsRequest reuse permissionsArticle Views140Altmetric-Citations38LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Comparison of vancomycin- and teicoplanin-induced histamine release and "red man syndrome" (1990)

Twelve healthy adult males participated in a double-blind, randomized, two-way crossover study to determine histamine release and the frequency and severity of "red man syndrome" (RMS) following intravenous administration of vancomycin (15 mg/kg of body weight over 60 min) and teicoplanin (15 mg/kg over 30 min). Concentrations of vancomycin and teicoplanin in serum and concentrations of histamine in plasma were measured at baseline and during and after each infusion. Erythema and pruritus were classified a priori as mild, moderate, or severe. The extent of erythema was determined by the use of a burn chart, and pruritus was assessed by the subject with a rank scale. Global severity of RMS was determined by summation of the individual scores for pruritus and erythema. Baseline areas under the concentration-time curve for histamine were not significantly different for the vancomycin and teicoplanin treatments. Vancomycin caused RMS in 11 of 12 subjects (9 severe and 2 moderate cases) and was associated with a significant increase in plasma histamine (46.7 +/- 31.3 ng.min/ml, P less than 0.05). In contrast, teicoplanin did not cause RMS or elicit significant histamine release (8.7 +/- 13.2 ng.min/ml). Peak concentrations of vancomycin and teicoplanin in serum were 58.8 +/- 8.4 and 148.0 +/- 31.8 micrograms/ml, respectively (P less than 0.05). Assuming equal efficacy, these data suggest that teicoplanin may be a safe alternative agent in subjects experiencing severe RMS due to vancomycin; however, further studies in the clinical setting are needed.
Raman spectroscopy on Mars: identification of geological and bio-geological signatures in Martian analogues using miniaturized Raman spectrometers (2014)

The first Raman spectrometers to be used for in situ analysis of planetary material will be launched as part of powerful, rover-based analytical laboratories within the next 6 years. There are a number of significant challenges associated with building spectrometers for space applications, including limited volume, power and mass budgets, the need to operate in harsh environments and the need to operate independently and intelligently for long periods of time (due to communication limitations). Here, we give an overview of the technical capabilities of the Raman instruments planned for future planetary missions and give a review of the preparatory work being pursued to ensure that such instruments are operated successfully and optimally. This includes analysis of extremophile samples containing pigments associated with biological processes, synthetic materials which incorporate biological material within a mineral matrix, planetary analogues containing low levels of reduced carbon and samples coated with desert varnish that incorporate both geo-markers and biomarkers. We discuss the scientific importance of each sample type and the challenges using portable/flight-prototype instrumentation. We also report on technical development work undertaken to enable the next generation of Raman instruments to reach higher levels of sensitivity and operational efficiency.
The Mechanism of the Cathodic Hydrogen Evolution Reaction (1952)

Some of the outstanding problems of concept and mechanism in the field of cathodic hydrogen evolution kinetics are discussed and clarified. A full derivation and correlation of kinetic equations which assume no mechanism reveals expressions for several parameters which take values specific to one or more mechanisms. The use of statistical methods of treatment of data proves indispensable in estimating the values of these parameters. A further method of ascertaining the mechanism of the hydrogen evolution reaction is to examine the kinetics of the individual reaction paths, so that the expected values of parameters common to all paths may be deduced. A number of mechanisms important in acid and alkaline solutions are thus treated, and are shown to be distinguishable experimentally. Using already published data, the actual conditions under which various reaction paths take place at mercury, silver, nickel, and smooth platinum cathodes are calculated. It is not only possible to compare these deduced data with observation, and thereby verify the occurrence of a particular reaction path, but also to demonstrate the impossibility of some mechanisms in specific cases. The recent advances which the foregoing methods have made possible are discussed in relation to data which have recently become available.