gebhart/patrepeval huggingface dataset:
Aufbau quartärer Stereozentren: neue Möglichkeiten durch enantioselektive Michael‐Reaktion (2003)

Durch PdII katalysierte Michael-Reaktionen zwischen β-Dicarbonylen 1 und Enonen 2 können quartäre Stereozentren (gelb unterlegt) mit Selektivitäten von 90 % ee bei relativ hohen Temperaturen (−10 °C) aufgebaut werden. Damit ist ein Durchbruch bei der enantioselektiven Synthese gelungen.
A new model for improving symbolic product machine traversal (1992)

The authors present algorithms for traversing product machines which improve on the results of H. Cho et al. (1991), with a speedup ranging from 3 up to 6. New features include a model that generalizes the product machine, resulting in simpler and more efficient representations and computations, as well as optimizations in symbolic image computation. In the latter case, the speedup ranged from 1.5 to 4. >
Monitoring of Industrial Water Usage by using Internet of Things (2018)

This paper focuses on monitoring the amount of usage of water in the milk processing unit and generates report of the daily water usage in each processing section. The system keeps track of the purchased water, water in reservoir and overall usage of water in the milk industry. The flow sensors will sense the flow of water in each pipe which ultimately tells the usage of water at one block ideally. The level sensor senses the level of water into the reservoir and tells the availability of water into the reservoir. This water usage data would be sent to the cloud using the Internet of Things (IoT) space. The cloud data is computed and generates pattern of the data input and provides a detailed water consumption chart on the desktop as well as smart phones.
Production of Potent Fully Human Polyclonal Antibodies against Ebola Zaire Virus in Transchromosomal Cattle (2016)

Polyclonal antibodies, derived from humans or hyperimmunized animals, have been used prophylactically or therapeutically as countermeasures for a variety of infectious diseases. SAB Biotherapeutics has successfully developed a transchromosomic (Tc) bovine platform technology that can produce fully human immunoglobulins rapidly, and in substantial quantities, against a variety of disease targets. In this study, two Tc bovines expressing high levels of fully human IgG were hyperimmunized with a recombinant glycoprotein (GP) vaccine consisting of the 2014 Ebola virus (EBOV) Makona isolate. Serum collected from these hyperimmunized Tc bovines contained high titers of human IgG against EBOV GP as determined by GP specific ELISA, surface plasmon resonance (SPR), and virus neutralization assays. Fully human polyclonal antibodies against EBOV were purified and evaluated in a mouse challenge model using mouse adapted Ebola virus (maEBOV). Intraperitoneal administration of the purified anti-EBOV IgG (100 mg/kg) to BALB/c mice one day after lethal challenge with maEBOV resulted in 90% protection; whereas 100% of the control animals succumbed. The results show that hyperimmunization of Tc bovines with EBOV GP can elicit protective and potent neutralizing fully human IgG antibodies rapidly and in commercially viable quantities.
Validation (2010)

Data integrity is a very important part of developing a software product. Users of software are human beings and, being such, are universally fallible. Whenever requiring input from a user—especially free-text input—the values that are supplied should be treated with extreme suspicion. When it comes to user input, data lives in a totalitarian state: it is all guilty until proven innocent and must be vigorously validated before being trusted.KeywordsBusiness LogicValidation ErrorValidation RuleValidation CodeCustom ValidationThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
An analysable bus-guardian for event-triggered communication (2004)

We present a guardian-based approach to detecting 'babbling idiots', faulty nodes which erroneously consume extra resource in an event triggered system. In general, one cannot detect all babbling idiots, but the maximum effect of undetected faults is bounded and small, and therefore can be taken into account in worst case response time analysis to guarantee that a babbling idiot cannot cause a timing failure elsewhere in the system. The approach is applied specifically to the CAN protocol to protect against faulty nodes transmitting message frames too often. We show that the overhead of including the effect of undetected frames into the worst case response time analysis is small enough to be of practical value.
A Novel Time-Resolved Fluoroimmunoassay Using a Macrocyclic Europium Ligand as a Label. (1994)

A novel macrocyclic ligand for Eu3+ (24, 30-diphenyl-1, 21 : 4, 6 : 10, 12 : 15, 17-tetraetheno-8, 9, 19, 20-tetrahydro-7H, 18H-dibenzo[b, k]-[1, 4, 7, 10, 13, 16]hexaazacyclooctadecine-8, 19-diacetic acid) was used to label an anti-human chorionic gonadotropin (hCG) monoclonal antibody. The time-resolved fluoroimmunoassay of hCG using this labeled antibody showed a linear response over the range 0.1 to 10 I.U. hCG/ml.
Planning and emotional health of abused adult children caregivers. (2005)

The purpose of this study was to explore markers associated with the advance-planning patterns and emotional health of adult child caregivers pre-selected for their history of childhood abuse within the family. An informational decision grid and two classification procedures were used to organize and link 246 written plans of 50 adults providing nearly 6 hours of care per day to a cognitively impaired parent. Results revealed 3 constellations of plans describing hands-on person-centred, instrumental, and grief-based approaches to caregiver planning. The 31 participants taking an instrumental approach to planning were significantly more likely than the 17 taking a grief-driven approach to report experiences of abandonment, betrayal, suicidal ideation, and use of alcohol. The 2 participants taking a person-centred approach reported significantly less emotional arousal and risk for loss of health and did not recount experiences of distress or emotion-focused coping. Nurses can use the findings to highlight and strengthen the decision-making and parental-care capacities of caregivers traumatized in childhood.
Structure and thermoelectric properties of the new quaternary tin selenide K1 − xSn5 − xBi11 + xSe22 (2000)

Silver colored ribbon-like crystals of K1 − xSn5 − xBi11 + xSe22 (x ≈ 0.33) were prepared by direct combination of K2Se, Bi2Se3, Sn and Se at 800 °C. A structure determination was carried out for K0.66Sn4.82Bi11.18Se22. Bi2Te3-type and NaCl-type building units are connected to form a new kind of three-dimensional anionic framework with K+ filled tunnels. The building units are assembled from distorted, edge-sharing (Bi,Sn)Se6 octahedra. Bi and Sn atoms are disordered over all metal sites of the chalcogenide network while the K site is only one third occupied. The charge transport measurements of K0.66Sn4.82Bi11.18Se22 at room temperature reveal an electrical conductivity of 450 S cm−1 and a thermopower of −43 µV K−1. The thermal conductivity is 1.5 W m−1 K−1. An optical band gap of approximately 0.12 eV was determined at room temperature. K0.66Sn4.82Bi11.18Se22 melts congruently at 680 °C.
Silicon–nitrogen compounds. Part V. Diphenylamino-derivatives of silane (1969)

Diphenylamine reacts with iodosilane and di-iodosilane to give diphenylaminosilane, SiH3NPh2, and bisdiphenylaminosilane, SiH2(NPh2)2, respectively. Some physical and chemical properties of the compounds are reported: in particular, both are very weak Lewis bases. Both compounds are thermally stable in vacuo at 310°; SiH3NPh2 decomposes at 355 or 380° to give hydrogen, silane, SiH2(NPh2)2, and diphenylamine, while benzene and hydrogen are evolved at 450°. The use of SiH3NPh2 in amine exchange reactions is investigated.
Use of Transcriptional Regulatory Sequences of Telomerase (hTER and hTERT) for Selective Killing of Cancer Cells (2000)

Telomerase (hTER and hTERT) plays a crucial role in cellular immortalization and carcinogenesis. Telomerase activity can be detected in about 85% of different malignant tumors, but is absent in most normal cells. In situ hybridization analysis showed that high levels of hTER and hTERT expression are present in bladder cancer, while no signal was detected in normal tissue. Therefore, in this work we propose to use hTER and hTERT transcriptional regulatory sequences to control the expression of a cytotoxic gene in bladder tumor cells, resulting in the selective destruction of this cell population. Expression vectors containing the diphtheria toxin A-chain (DT-A) gene were linked to hTER and hTERT transcriptional regulatory sequences, respectively. Inhibition of protein synthesis occurred in bladder and hepatocellular carcinoma cells transfected with the plasmids containing the DT-A gene under the control of the hTER or hTERT promoters in correlation with their activity. These studies support the feasibility of using hTER and hTERT transcriptional regulatory sequences for targeted patient-oriented gene therapy of human cancer.
Optimal rates of convergence for persistence diagrams in Topological Data Analysis (2013)

Computational topology has recently known an important development toward data analysis, giving birth to the field of topological data analysis. Topological persistence, or persistent homology, appears as a fundamental tool in this field. In this paper, we study topological persistence in general metric spaces, with a statistical approach. We show that the use of persistent homology can be naturally considered in general statistical frameworks and persistence diagrams can be used as statistics with interesting convergence properties. Some numerical experiments are performed in various contexts to illustrate our results.
A prototype node for wireless vision sensor network applications development (2010)

This paper presents a prototype vision-enabled sensor node based on a commercial vision system of reduced size and power consumption. The wireless infrastructure for the deployment of a distributed smart camera network based on these nodes is provided by commercial motes. The smart camera, based on a low-power bio-inspired processing scheme, enables in-node image processing and vision tools. This permits to elaborate a lighter representation of the scene, keeping the relevant information in terms of detected elements, features and events, alleviating the data transmission through the network. Therefore by passing only the relevant information to the neighboring sensor nodes, distributed and collaborative vision is possible with the limited data rates available in commercial wireless sensor networks. Communication between the different components of the system is supported by the available UARTs and GPIOs. Several examples of in-node image processing and feature detection has been tested in the prototype, and information at different abstraction levels has been broadcasted to the network.
Crack‐Shape Effects for Indentation Fracture Toughness Measurements (1992)

Various methods to measure fracture toughness using in‐dentation precracks were compared using soda‐lime glass as a test material. In situ measurements of crack size as a function of applied stress allow both the toughness K c and the residual‐stress factor χ to be independently determined. Analysis of the data showed that stress intensity factors based on classical half‐penny crack shapes overestimate toughness values and produce an apparent R ‐curve effect. This is due to a constraint on crack shape imposed by primary lateral cracks in soda—lime glass. Models based on elliptical cracks were developed to account for the crack‐shape effects.
[Clinical study of tumor markers in prostatic carcinoma--an investigation on the simultaneous measurement of prostatic acid phosphatase (PAP), prostatic antigen (PA) and gamma-seminoprotein (gamma-Sm)]. (1988)

Measurements of prostatic acid phosphatase (PAP), prostatic antigen (PA) and gamma-seminoprotein (gamma-Sm) have been found to be clinically useful in the diagnosis of prostatic carcinoma, but, the usefulness of simultaneous measurement has not yet been elucidated. We determined the clinical significance of simultaneous measurement of these markers, especially, the additional measurement of PA or gamma-Sm to PAP in prostatic carcinoma. Each measurement of PAP, PA and gamma-Sm yielded a very low "false" positive rate (0-6.5%) in patients with non-prostatic urogenital disease or benign prostatic hypertrophy (BPH), which was consistent with the results reported so far by other researchers. Eighteen patients with newly diagnosed prostatic carcinoma of a low stage showed a positive rate of PAP in 16.7%, PA in 33.3% and gamma-Sm in 38.9%. Forty patients having a high stage had a positive rate of 67.5% for each of the markers. In patients with BPH, the positive rate was elevated in only 2.6, 5.2 or 3.9% by the additional measurement of PA or gamma-Sm to PAP, or that of gamma-Sm to PA, respectively. This implied that the additional measurement of other markers to PAP or PA produced only a low elevation of the "false" positive rate. The positive rate in patients with prostatic carcinoma of low stage was increased by the additional measurement of PA or gamma-Sm to PAP or that of gamma-Sm to PA. This suggests that in patients with low stage carcinoma, assay with these combinations would be clinically useful to monitor the patient's clinical course.(ABSTRACT TRUNCATED AT 250 WORDS)
Bending optical solitons in nonlinear photonic crystal waveguides (2004)

We investigate the propagation of optical solitons through nonlinear photonic crystal (PC) waveguide bends. Our studies focus on the waveguide bends in two-dimensional PC slabs which are widely used for the manipulation of photons. It is found that optical solitons are completely destroyed when trying to pass through the conventional waveguide bend. With appropriate modifications to the bend structure, however, perfect transmission of optical solitons can be realized. The criteria for the design of waveguide bends with low reflection loss are also generalized.
Triply periodic smectic liquid crystals (2007)

Twist-grain-boundary phases in smectics are the geometrical analogs of the Abrikosov flux lattice in superconductors. At large twist angles, the nonlinear elasticity is important in evaluating their energetics. We analytically construct the height function of a pi2 twist-grain-boundary phase in smectic-A liquid crystals, known as Schnerk's first surface. This construction, utilizing elliptic functions, allows us to compute the energy of the structure analytically. By identifying a set of heretofore unknown defects along the pitch axis of the structure, we study the necessary topological structure of grain boundaries at other angles, concluding that there exist a set of privileged angles and that the pi2 and pi3 grain boundary structures are particularly simple.
Multiple Splice Variants of the Human HIF-3α Locus Are Targets of the von Hippel-Lindau E3 Ubiquitin Ligase Complex (2003)

Functional inactivation of the von Hippel-Lindau (VHL) tumor suppressor protein is the cause of familial VHL disease and sporadic kidney cancer. The VHL gene product (pVHL) is a component of an E3 ubiquitin ligase complex that targets the hypoxia-inducible factor (HIF) 1 and 2 alpha subunits for polyubiquitylation. This process is dependent on the hydroxylation of conserved proline residues on the alpha subunits of HIF-1/2 in the presence of oxygen. In our effort to identify orphan HIF-like proteins in the data base that are potential targets of the pVHL complex, we report multiple splice variants of the human HIF-3 alpha locus as follows: hHIF-3 alpha 1, hHIF-3 alpha 2 (also referred to as hIPAS; human inhibitory PAS domain protein), hHIF-3 alpha 3, hHIF-3 alpha 4, hHIF-3 alpha 5, and hHIF-3 alpha 6. We demonstrate that the common oxygen-dependent degradation domain of hHIF-3 alpha 1-3 splice variants is targeted for ubiquitylation by the pVHL complex in vitro and in vivo. This activity is enhanced in the presence of prolyl hydroxylase and is dependent on a proline residue at position 490. Furthermore, the ubiquitin conjugation occurs on lysine residues at position 465 and 568 within the oxygen-dependent degradation domain. These results demonstrate additional targets of the pVHL complex and suggest a growing complexity in the regulation of hypoxia-inducible genes by the HIF family of transcription factors.
Slow/cardiac sarcoplasmic reticulum Ca<sup>2+</sup>‐ATPase and phospholamban mRNAs are expressed in chronically stimulated rabbit fast‐twitch muscle (1989)

Fast-twitch extensor digitorum longus muscles of the rabbit were subjected to chronic low-frequency stimulation during different time periods. Changes in the relative amounts of mRNAs encoding fast and slow/cardiac Ca2+-ATPase isoforms were assessed through the use of an RNase-protection assay. Stimulation-induced increases in slow cardiac Ca2+-ATPase and phospholamban mRNAs were quantified by mRNA hybridization. Prolonged stimulation resulted in an exchange of the fast with the slow/cardiac Ca2+-ATPase isoform mRNAs. The exchange was complete after 72 d of stimulation as compared with normal slow-twitch soleus muscle. The tissue content of phospholamban mRNA reached levels similar to that found in normal slow-twitch soleus muscle by the same time. The conversion of the sarcoplasmic reticulum coincided with the fast-to-slow troponin C isoform transition, previously investigated in the same muscles.
Nuclear Exclusion of Wild-Type p53 in Immortalized Human Retinoblastoma Cells (1997)

Some immortalized retinoblastoma cells may exhibit p53 dysfunction through nuclear exclusion of wild-type p53 protein.
A Systems Approach to the Torque Control of a Permanent Magnet Brushless Motor (1987)

Many approaches to force control have assumed the ability to command torques accurately. Concurrently, much research has been devoted to developing accurate torque actuation schemes. Often, torque sensors have been utilized to close a feedback loop around output torque. In this paper, the torque control of a brushless motor is investigated through: the design, construction, and utilization of a joint torque sensor for feedback control; and the development and implementation of techniques for phase current based feedforeward torque control. It is concluded that simply closing a torque loop is no longer necessarily the best alternative since reasonably accurate current based torque control is achievable.
Hydrocarbon polymers containing six-membered rings in the main chain. Microstructure and properties of poly(1,3-cyclohexadiene) (1998)

The relationship between the microstructure and the properties of poly(1,3-cyclohexadiene)s, obtained by living anionic polymerization with an alkyllithium/amine system, and their hydrogenated derivatives are reported. The 1,2-bond/1,4-bond molar ratio of poly(1,3-cyclohexadiene) was determined by measuring 2D-NMR with the HH COSY method. The glass transition temperature of poly(1,3-cyclohexadiene) was found to rise with an increase in the ratio of 1,2-bonds to 1,4-bonds or with an increase of the number average molecular weight. The 1,2-bond of the polymer chain gives a high flexural strength and heat distortion temperature. Hydrogenated poly(1,3-cyclohexadiene) has the highest Tg (231°C) among all hydrocarbon polymers ever reported. 1,3-Cyclohexadiene–butadiene–1,3-cyclohexadiene triblock copolymer and 1,3-cyclohexadiene–styrene–1,3-cyclohexadiene triblock copolymer have high heat resistance and high mechanical strength. © 1998 John Wiley & Sons, Inc. J Polym Sci B: Polym Phys 36: 1657–1668, 1998
Protection of Infants from Infection with Influenza A Virus by Transplacentally Acquired Antibody (1980)

Transplacentally acquired antibody to influenza A virus was measured by a microneutralization test and a radioimmunoprecipitation assay in cord blood obtained from infants at a large urban county hospital in 1975-1978. Random samples tested before epidemic periods were a measure of susceptibility of the population. Twenty-six infants from whom cord sera were available had culture-documented infections with influenza A/Victoria (H3N2) virus when younger than four months. The direct correlation between age at the time of infection and level of antibody measured in cord serum (P less than 0.002) suggested a protective effect of transplacentally acquired antibody. None of fourteen acute-phase serum specimens obtained early in the course of culture-positive infections of young infants had detectable antibody to influenza A viral hemagglutinin by the sensitive radioimmunoprecipitation test. Because passively transferred maternal antibody to influenza virus may prevent symptomatic infection in young infants, vaccination of pregnant women could be beneficial.
Materials and processes for fiber preform fabrication—Vapor-phase axial deposition (1980)

The vapor-phase axial deposition (VAD) process was developed to realize continuous fabrication of high-silica fiber preforms. This process could be used to fabricate various kinds of optical fibers such as graded-index, single-mode, and high NA fibers. Transmission characteristics of these VAD fibers have improved to the level almost comparable to the best values attained by the MCVD process. The VAD process has excellent prospects as an economical means to produce long-length fibers with good transmission characteristics.
Technology or Craft: What Are We Doing?. (1998)

entire body of methods and materials used to achieve such objectives Craft (kr|ft, kräft) n. pl. crafts. Skill or ability in something... Proficiency; expertness... Indicates work, art or practice of, for example, woodcraft, stagecraft.2 ________________________________ The origin of this essay was a request from the Editor, Larry Lipsitz, for a reflective article on where we currently stand and where we are going in Educational Technology. His concern is based, in part, on the perception of a number of people who have monitored educational
Hydrogen production during the anaerobic acidogenic conversion of glucose (1999)

Experiments on hydrogen production using chemostat-type anaerobic digesters were conducted. The results indicate that the anaerobic acidogenic conversion of glucose can produce hydrogen. The hydrogenic activity of acclimated anaerobic sewage sludge is high at a short solids retention time (SRT) and low pH. At pH 5.7, SRT 0.25 days and an organic loading rate of 416 mmol-glucose dm−3 day−1, each mole of glucose in the mesophilic acidogenic reactor can produce 1.7 mol of hydrogen; each gram of biomass produces 0.456 mole of hydrogen per day. Moreover, the hydrogen productivity of the sludge is comparable to that of an enrichment culture. © 1999 Society of Chemical Industry
OCCUPATIONAL DISABILITY AFTER HOSPITALIZATION FOR THE TREATMENT OF AN INJURY OF THE ANTERIOR CRUCIATE LIGAMENT (2003)

In keeping with risk profiles of several other musculoskeletal disorders, such as low-back pain and carpal tunnel syndrome, the results revealed a multifactorial risk profile in which psychosocial factors were strongly associated with disability discharge from active military duty after injury of the anterior cruciate ligament.
Real-time kernel in hardware RTU: a step towards deterministic and high-performance real-time systems (2002)

Demands on real-time kernels increase every year: as applications grow larger and become more complex, real-time kernels must give short and predictable response. The RTU is a real-time kernel coprocessor implemented in an ASIC, which is intended to meet the growing expectations on real-time kernels. Since the RTU gives fast response times, it is necessary to define a detailed time-model to improve the understanding of the real-time kernel behaviour in the /spl mu/S-domain. In this paper, we describe how to use the RTU in a single-or multi-processor architecture and a time-model for a RTU based real-time system is defined. The time-model is considered with regards to determinism and performance.