gebhart/patrepeval huggingface dataset:
Modulation of Host-Immune Responses by Ticks (Acari: Ixodidae): Effect of Salivary Gland Extracts on Host Macrophages and Lymphocyte Cytokine Production (1992)

Ixodid tick infestation induces host acquired resistance, which involves immunoglobulin cell-mediated and complement-dependent effector pathways. Ticks have developed countermeasures to modulate host antiarthropod responses. Ixodid-mediated host immunomodulation results in vitro in reduced responsiveness to T-lymphocyte mitogens for cells obtained from infested hosts and impaired antibody responses to a thymic dependent antigen. Salivary gland extracts from days 0-9 of engorgement from unmated, female Dermacentor andersoni Stiles suppressed lymphocyte proliferative responses (LPS) to the T-cell mitogen Con A up to 68.4%, whereas responsiveness to E. coli LPS was enhanced. Cytokines assessed in this study included interleukin-1, IL-1, and tumor necrosis factor (TNF) alpha produced by macrophages, and interleukin-2, IL-2, and gamma interferon (IFN-G) secreted by T-lymphocytes. Salivary gland extracts prepared from tissues obtained on days 0-5 of engorgement suppressed IL-1 elaboration from 89.8% on day 0 through 37.5% on day 6. Levels of TNF were reduced from 40.7 to 94.6% throughout the course of the study. Production of IL-2 was suppressed by 14.1-31.9%, and IFN-G was reduced by 8.7-57.0%. Reduced IL-1 levels during the early phases of feeding indicated reduced host ability to activate T-lymphocytes and provide costimulatory, differentiation, and development signals for B-cells. Both IL-1 and TNF are endogenous pyrogens and activate polymorphonuclear leukocytes. Activities of TNF and IFN-G include antiviral properties and induction of expression of class I and II major histocompatibility complex molecules, which are critical components in the recognition of antigen by T-lymphocytes. The autocrine role of IL-2 in proliferation of T-lymphocytes is central to the development of immune reactivity involving T-cell regulation or effector functions or both. Reductions in cytokine levels would suppress immune responses directed toward immunogens introduced into the host during the course of tick feeding. These results indicates that immunomodulation of the host during tick feeding facilitates engorgement and pathogen transmission.
On the role of coherence in abductive explanation (1990)

Abduction is an important inference process underlying much of human intelligent activities, including text understanding, plan recognition, disease diagnosis, and physical device diagnosis. In this paper, we describe some problems encountered using abduction to understand text, and present some solutions to overcome these problems. The solutions we propose center around the use of a different criterion, called explanatory coherence, as the primary measure to evaluate the quality of an explanation. In addition, explanatory coherence plays an important role in the construction of explanations, both in determining the appropriate level of specificity of a preferred explanation, and in guiding the heuristic search to efficiently compute explanations of sufficiently high quality. 1 Introduction Finding explanations for properties and events is an important aspect of text understanding and of intelligent behavior in general. The philosopher C.S. Peirce defined abduction as the process of...
Isolation of cleaved prolactin variants that stimulate DNA synthesis in specific cell types in rat pituitary cell aggregates in culture (1992)

Using an affinity column of monoclonal antibodies against rat prolactin (PRL), PRL immunoreactive material secreted by rat pituitary aggregate cell cultures was purified in milligram amounts from the culture medium. Further purification of the PRL immunoreactive molecules was achieved by anion-exchange and reversed-phase h.p.l.c. At least four variants could be distinguished which showed PRL-like bioactivity in the Nb2 lymphoma bioassay. On SDS/PAGE two variants migrated as single bands under both reducing and non-reducing conditions. The two other variants migrated as single bands under non-reducing conditions, but yielded under reducing conditions two fragments, the larger of which had molecular masses of approx. 16 and 17 kDa respectively. These variants were therefore considered to be cleaved PRL (clPRL) variants, and were designated clPRL-1 and clPRL-2 respectively. These variants were not artefactually produced at low pH during the h.p.l.c. purification step. Each of the clPRLs represented about 0.6-1.0% of total PRL. The cleavage site of clPRL-1, determined by N-terminal and C-terminal amino acid sequence analysis, was in the large disulphide loop between Tyr-145 and Leu-146. Purified clPRL-1 added to pituitary aggregate cell cultures from 14-day-old female rats in the presence of the dopamine agonist bromocriptine increased [3H]thymidine incorporation into DNA in gonadotrophs and thyrotrophs, but not in other pituitary cell types. Under the same experimental conditions the main forms of PRL and clPRL-2 were inactive. These data demonstrate that PRL is cleaved within the pituitary gland between specific amino acid residues, and that PRL cleaved between Tyr-145 and Leu-146 may have a specific biological role as a paracrine growth regulator in this tissue.
Acetyl-Coenzyme A: Arylamine N-Acetyltransferase (1971)

The reactions of p-nitroacetanilide and p-nitrophenyl acetate with aromatic and aliphatic amines catalyzed by a partially purified preparation of acetyl-coenzyme A:arylamine acetyltransferase follow ping-pong kinetics. At a given concentration of p-nitroacetanilide the identical maximum velocities observed for five substituted anilines, semicarbazide, hydroxylamine, and hydrazine, suggest that these reactions proceed through the rate-determining formation of a common acetyl-enzyme intermediate which reacts with the acceptor amine in a fast step. The maximum velocities are directly proportional to the p-nitroacetanilide concentration. p-Nitrophenyl acetate is the most active acyl donor substrate known for the enzyme, with a maximum velocity approximately 140-fold larger than that of acetyl-CoA. With weakly basic anilines the maximum velocity is different for different acyl acceptors, suggesting that with these substrates the reaction of the acetyl-enzyme intermediate with the acceptor amine is rate determining and that the saturation with increasing amine concentration represents binding of the acceptor amine to the acyl-enzyme. With strongly basic anilines the maximum velocities and the Km for p-nitrophenyl acetate are identical, within experimental error, for all anilines; this is interpreted as evidence for a change to rate-determining acylation of the enzyme with these more reactive nucleophiles. The increase in reactivity with increasing aniline basicity suggests the development of a partial positive charge on the attacking nitrogen atom, which may be accompanied by a relatively small degree of proton removal by a general base catalyst. It is suggested that the wide variation in the sensitivity of enzyme-catalyzed acyl transfer reactions to the basicity of the nucleophile or leaving group reflects different degrees of proton removal or addition by general acid-base catalysts in the transition state.
The Market for "Lemons": Quality Uncertainty and the Market Mechanism (1970)

I. Introduction, 488. — II. The model with automobiles as an example, 489. — III. Examples and applications, 492. — IV. Counteracting institutions, 499. — V. Conclusion, 500.
REGIMES OF MASS TRANSFER WITH CHEMICAL REACTION (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTREGIMES OF MASS TRANSFER WITH CHEMICAL REACTIONGiovanni AstaritaCite this: Ind. Eng. Chem. 1966, 58, 8, 18–26Publication Date (Print):August 1, 1966Publication History Published online1 May 2002Published inissue 1 August 1966https://pubs.acs.org/doi/10.1021/ie50680a006https://doi.org/10.1021/ie50680a006research-articleACS PublicationsRequest reuse permissionsArticle Views1239Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Uncalibrated Multiple Image Stereo System with Arbitrarily Movable Camera and Projector for Wide Range Scanning (2005)

In this paper, we propose an uncalibrated, multi-image 3D reconstruction, using coded structured light. Normally, a conventional coded structured light system consists of a camera and a projector and needs precalibration before scanning. Since the camera and the projector have to be fixed after calibration, reconstruction of a wide area of the scene or reducing occlusions by multiple scanning are difficult and sometimes impossible. In the proposed method, multiple scanning while moving the camera or the projector is possible by applying the uncalibrated stereo method, thereby achieving a multi-image 3D reconstruction. As compared to the conventional coded structured light method, our system does not require calibration of extrinsic camera parameters, occlusions are reduced, and a wide area of the scene can be acquired. As compared to image-based multi-image reconstruction, the proposed system can obtain dense shape data with higher precision. As a result of these advantages, users can freely move either the cameras or projectors to scan a wide range of objects, but not if both the camera and the projector are moved at the same time.
Learning unified features from natural and programming languages for locating buggy source code (2016)

Bug reports provide an effective way for end-users to disclose potential bugs hidden in a software system, while automatically locating the potential buggy source code according to a bug report remains a great challenge in software maintenance. Many previous studies treated the source code as natural language by representing both the bug report and source code based on bag-of-words feature representations, and correlate the bug report and source code by measuring similarity in the same lexical feature space. However, these approaches fail to consider the structure information of source code which carries additional semantics beyond the lexical terms. Such information is important in modeling program functionality. In this paper, we propose a novel convolutional neural network NP-CNN, which leverages both lexical and program structure information to learn unified features from natural language and source code in programming language for automatically locating the potential buggy source code according to bug report. Experimental results on widely-used software projects indicate that NP-CNN significantly outperforms the state-of-the-art methods in locating the buggy source files.
Community Organization Approaches to the Prevention of Juvenile Delinquency (1985)

This paper examines juvenile delinquency prevention programs which implement large-scale intervention and social change strategies. A typology of community organization practice is used to analyze the assumptions, objectives, and methods underlying these approaches. Three models of community organization-- locality development, social planning, and social action--are used to evaluate three exemplary delinquency prevention programs: the Chicago Area Project, the 1960's provision of opportunity programs, and the 1960's comprehensive community-based projects such as Mobilization for Youth. The difficulties encountered in implementing these models and programs are identified and assessed. The implications for contemporary crime prevention efforts are also considered.
<i>Neisseria meningitidis</i> NadA is a new invasin which promotes bacterial adhesion to and penetration into human epithelial cells (2004)

Neisseria meningitidis is a human pathogen, which is a major cause of sepsis and meningitis. The bacterium colonizes the upper respiratory tract of approximately 10% of humans where it lives as a commensal. On rare occasions, it crosses the epithelium and reaches the bloodstream causing sepsis. From the bloodstream it translocates the blood-brain barrier, causing meningitis. Although all strains have the potential to cause disease, a subset of them, which belongs to hypervirulent lineages, causes disease more frequently than others. Recently, we described NadA, a novel antigen of N. meningitidis, present in three of the four known hypervirulent lineages. Here we show that NadA is a novel bacterial invasin which, when expressed on the surface of Escherichia coli, promotes adhesion to and invasion into Chang epithelial cells. Deletion of the N-terminal globular domain of recombinant NadA or pronase treatment of human cells abrogated the adhesive phenotype. A hypervirulent strain of N. meningitidis where the nad A gene was inactivated had a reduced ability to adhere to and invade into epithelial cells in vitro. NadA is likely to improve the fitness of N. meningitidis contributing to the increased virulence of strains that belong to the hypervirulent lineages.
The Influence of Adiponectin Gene Polymorphism on the Rosiglitazone Response in Patients With Type 2 Diabetes (2005)

These data suggest that genetic variations in the adiponectin gene can affect the rosiglitazone treatment response of the circulating adiponectin level and blood glucose control in type 2 diabetic patients.
Chondroitin Sulfate Hydrogel and Wound Healing in Rabbit Maxillary Sinus Mucosa (2004)

Despite some limitations, the New Zealand white rabbit is an effective model for the study of sinonasal wound healing. CS hydrogel accelerates wound healing in sinonasal mucosa at a 4-day endpoint. We propose that the CS hydrogel acts as a surrogate extracellular matrix, serving as a repository for cytokines and growth factors produced by the regenerating mucosa. It may also provide a structural framework for fibroblasts and epithelial regeneration. Further study is necessary to establish this relationship.
Is the Circulating Ouabain-like Compound Ouabain? (1994)

The evidence is very strong for a circulating inhibitor of the sodium, potassium ATPase in volume expanded hypertension. Recently, this inhibitor was isolated from human plasma and identified as ouabain. We are reporting our results using a very specific and sensitive immunoassay for ouabain with which we were unable to detect or able to detect only very low levels of circulating immuno reactive ouabain. Immunoassay of 5 mL of human and rat plasma, incubation fluid from bovine and human adrenal cell cultures extracted using a C-18 solid phase column, and HPLC separation did not detect a peak corresponding to ouabain. This procedure could easily detect authentic ouabain added to these extracts at a concentration slightly below that reported to be present by others. The extract from the adrenal cultures had clearly detectable sodium, potassium ATPase using an assay based on inhibition of tritiated ouabain binding to human red cells. Extraction of bovine adrenals detected a very small amount of immnoassayable ouabain which did not elute at a time corresponding to that of ouabain. This study indicates that the postulated sodium, potassium ATPase inhibitor that circulates in plasma is not ouabain, but it is likely to be structurally similar to ouabain, as it appears to cross-react with some antibodies against ouabain. Am J Hypertens 1994;7:647-650
Development of Transgenic Orchardgrass ( Dactylis glomerata L. ) Using Agrobacterium tumefaciens (2000)

To produce of transgenic orchardgrass, the seed-derived calli of orchardgrass (Dactylis glomerata L.) co-cultivated with Agrobacterium turnefaciens EHAlOl harboring binary vector pIG121-Hm were selected with hygromycin and then transferred onto N6 regeneration medium containing 1 rngl l of NAA, 5 rngl l of kinetin, 250 rngl l of carbenicillin and 50 mg/ l of hygromycin. The efficiency of transformation was differed on cultivars, that is, 'Potomac' appeared 12% of transformation efficiency while 'Amba' did 5.5%. The addition of acetosyringone during co-cultivation was a key to successhl transformation of orchardgrass. Transgene fragments were identified by PCR analysis and the constitutive expression of GUS gene was confirmed by Northern blot analysis. (Key words : Acetosyringone, Agrobacterium tumefaciens, Orchardgrass (Dactylis glomerata L.), Transformation)
Examination of peripheral blood films using automated microscopy; evaluation of Diffmaster Octavia and Cellavision DM96 (2006)

The Octavia and the DM96 are automated cell analysis systems capable of morphological classification of RBCs and WBCs in peripheral blood smears. Classification accuracy depends on the type of pathological changes in the blood sample. Both systems operate most effectively in the analysis of non-pathological blood samples.
Evaluation of Interventions Intended to Increase Colorectal Cancer Screening Rates in the United States (2018)

Fecal blood test outreach and patient navigation, particularly in the context of multicomponent interventions, were associated with increased CRC screening rates in US trials. Fecal blood test outreach should be incorporated into population-based screening programs. More research is needed on interventions to increase adherence to continued FBTs, follow-up of abnormal initial screening test results, and cost-effectiveness and other implementation barriers for more intensive interventions, such as navigation.
Earthquake-Induced Building Damage Detection with Post-Event Sub-Meter VHR TerraSAR-X Staring Spotlight Imagery (2016)

Compared with optical sensors, Synthetic Aperture Radar (SAR) can provide important damage information due to its ability to map areas affected by earthquakes independently from weather conditions and solar illumination. In 2013, a new TerraSAR-X mode named staring spotlight (ST), whose azimuth resolution was improved to 0.24 m, was introduced for various applications. This data source made it possible to extract detailed information from individual buildings. In this paper, we present a new concept for individual building damage assessment using a post-event sub-meter very high resolution (VHR) SAR image and a building footprint map. With the building footprint map, the original footprints of buildings can be located in the SAR image. Based on the building imaging analysis of a building in the SAR image, the features in the building footprint can be extracted to identify standing and collapsed buildings. Three machine learning classifiers, including random forest (RF), support vector machine (SVM) and K-nearest neighbor (K-NN), are used in the experiments. The results show that the proposed method can obtain good overall accuracy, which is above 80% with the three classifiers. The efficiency of the proposed method is demonstrated based on samples of buildings using descending and ascending sub-meter VHR ST images, which were all acquired from the same area in old Beichuan County, China.
Typechecking and modules for multi-methods (1994)

Two major obstacles hindering the wider acceptance of multi-methods are concerns over the lack of encapsulation and modularity and the absence of static typechecking in existing multi-method-based languages. This paper addresses both of these problems. We present a polynomial-time static typechecking algorithm that checks the conformance, completeness, and consistency of a group of method implementations with respect to declared message signatures. This algorithm improves on previous algorithms by handling separate type and inheritance hierarchies, abstract classes, and graph-based method lookup semantics. We also present a module system that enables independently-developed code to be fully encapsulated and statically typechecked on a per-module basis. To guarantee that potential conflicts between independently-developed modules have been resolved, a simple well-formedness condition on the modules comprising a program is checked at link-time. The typechecking algorithm and module system are applicable to a range of multi-method-based languages, but the paper uses the Cecil language as a concrete example of how they can be applied.
Synthetase with a difference (1990)

HBY genomes in human HCC have generally been unsuccessful, although individual examples of HB Y insertions next to genes for retinoic acid receptor" and cyclin A' have been identified.Unfortunately,
Synthesis of a polysulfated heparin degradation product. (2004)

Two suitable methods for the synthesis of the heparin degradation product 2,5-anyhydro-3-O-(alpha-L-idopyranosyluronate)-D-mannitol hexa O-sulfate are reported. The synthesis pathways start from D-glucose and D-glucosamine.
De Novo Ceramide Regulates the Alternative Splicing of Caspase 9 and Bcl-x in A549 Lung Adenocarcinoma Cells (2002)

Previous studies have demonstrated that several splice variants are derived from both the caspase 9 and Bcl-x genes in which the Bcl-x splice variant, Bcl-x(L) and the caspase 9 splice variant, caspase 9b, inhibit apoptosis in contrast to the pro-apoptotic splice variants, Bcl-x(s) and caspase 9. In a recent study, we showed that ceramide induces the dephosphorylation of SR proteins, a family of protein factors that regulate alternative splicing. In this study, the regulation of the alternative processing of pre-mRNA of both caspase 9 and Bcl-x(L) was examined in response to ceramide. Treatment of A549 lung adenocarcinoma cells with cell-permeable ceramide, D-e-C(6) ceramide, down-regulated the levels of Bcl-x(L) and caspase 9b mRNA and immunoreactive protein with a concomitant increase in the mRNA and immunoreactive protein levels of Bcl-x(s) and caspase 9 in a dose- and time-dependent manner. Pretreatment with calyculin A (5 nm), an inhibitor of protein phosphatase-1 (PP1) and protein phosphatase 2A (PP2A) blocked ceramide-induced alternative splicing in contrast to okadaic acid (10 nm), a specific inhibitor of PP2A at this concentrations in cells, demonstrating a PP1-mediated mechanism. A role for endogenous ceramide in regulating the alternative splicing of caspase 9 and Bcl-x was demonstrated using the chemotherapeutic agent, gemcitabine. Treatment of A549 cells with gemcitabine (1 microm) increased ceramide levels 3-fold via the de novo sphingolipid pathway as determined by pulse labeling experiments and inhibition studies with myriocin (50 nm), a specific inhibitor of serine palmitoyltransferase (the first step in de novo synthesis of ceramide). Treatment of A549 cells with gemcitabine down-regulated the levels of Bcl-x(L) and caspase 9b mRNA with a concomitant increase in the mRNA levels of Bcl-x(s) and caspase 9. Again, inhibitors of ceramide synthesis blocked this effect. We also demonstrate that the change in the alternative splicing of caspase 9 and Bcl-x occurred prior to apoptosis following treatment with gemcitabine. Furthermore, doses of D-e-C(6) ceramide that induce the alternative splicing of both caspase 9 and Bcl-x-sensitized A549 cells to daunorubicin. These data demonstrate a role for protein phosphatases 1 (PP1) and endogenous ceramide generated via the de novo pathway in regulating this mechanism. This is the first report on the dynamic regulation of RNA splicing of members of the Bcl-2 and caspase families in response to regulators of apoptosis.