gebhart/patrepeval huggingface dataset:
Characterization of [dimethyl N,N'-ethylenebis(L-cysteinato)(2-)-S,S']copper(II), a stable copper(II) aliphatic dithiolate (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCharacterization of [dimethyl N,N'-ethylenebis(L-cysteinato)(2-)-S,S']copper(II), a stable copper(II) aliphatic dithiolateParimal K. Bharadwaj, Joseph A. Potenza, and Harvey J. SchugarCite this: J. Am. Chem. Soc. 1986, 108, 6, 1351–1352Publication Date (Print):March 1, 1986Publication History Published online1 May 2002Published inissue 1 March 1986https://pubs.acs.org/doi/10.1021/ja00266a067https://doi.org/10.1021/ja00266a067research-articleACS PublicationsRequest reuse permissionsArticle Views207Altmetric-Citations54LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Etiology of Cat Scratch Disease: Comparison of Polymerase Chain Reaction Detection of Bartonella (Formerly Rochalimaea) and Afipia felis DNA with Serology and Skin Tests (1995)

To determine the role of Bartonella (formerly Rochalimaea) species and Afipia felis in cat scratch disease (CSD), two polymerase chain reaction (PCR) hybridization assays were developed to detect DNA from these organisms. These assays were applied on 89 pus aspirates from skin test-positive CSD patients (group 1) and on 137 pus and lymph node specimens from CSD suspects (group 2). Bartonella DNA was detected in 96% of the samples from group 1 patients and in 60% of group 2 samples; however, A. felis DNA could not be detected in any clinical samples. These results suggest that CSD is caused by bartonellae and that A. felis does not play a significant role in this zoonosis. A strong correlation between Bartonella PCR positivity and Bartonella henselae antibody titer was found. Comparison of CSD skin test results with those obtained by Bartonella PCR suggests a low sensitivity of the skin test.
Vitamin Supplements and Cardiovascular Risk: Review of the Randomized Trials of Homocysteine-Lowering Vitamin Supplements (2000)

Epidemiological studies have shown that higher blood homocysteine levels appear to be associated with higher risks of coronary, cerebral, and peripheral vascular disease and are inversely related to blood levels of folate and of vitamin B12 and vitamin B6. However, observational studies cannot exclude the possibility that elevated homocysteine levels may be associated with some other factor, rather than being causally related to vascular disease. Large-scale clinical trials of sufficient dose and duration of treatment are required to test this hypothesis, but there was substantial uncertainty about the optimal vitamin regimen to test in such trials. A meta-analysis of 12 randomized trials of vitamin supplements to lower homocysteine levels was carried out to determine the optimal dose of folic acid required to lower homocysteine levels and to assess whether vitamin B12 or vitamin B6 had additive effects. This meta-analysis demonstrated that reductions in blood homocysteine levels were greater at higher pretreatment blood homocysteine levels and at lower pretreatment folate concentrations. After standardization for a pretreatment homocysteine concentration of 12 micromol/L and folate concentration of 12 nmol/L (approximate average concentrations for western populations), dietary folic acid reduced homocysteine levels by 25% (95% confidence interval [CI]: 23 to 28%) with similar effects in a daily dosage range of 0.5 to 5 mg. Vitamin B12 (mean 0.5 mg) produced an additional reduction in blood homocysteine of 7%, whereas vitamin B6 (mean 16.5 mg) did not have any significant effect. Hence, in typical populations, daily supplementation with both 0.5 to 5 mg folic acid and about 0.5 mg vitamin B12 would be expected to reduce homocysteine levels by one quarter to one third (from about 12 micromol/L to about 8 to 9 micromol/L). Large-scale randomized trials of such regimens are now required to determine whether lowering homocysteine levels by folic acid and vitamin B12, with or without added vitamin B6, reduces the risk of vascular disease.
Privacy and contextual integrity: framework and applications (2006)

Contextual integrity is a conceptual framework for understanding privacy expectations and their implications developed in the literature on law, public policy, and political philosophy. We formalize some aspects of contextual integrity in a logical framework for expressing and reasoning about norms of transmission of personal information. In comparison with access control and privacy policy frameworks such as RBAC, EPAL, and P3P, these norms focus on who personal information is about, how it is transmitted, and past and future actions by both the subject and the users of the information. Norms can be positive or negative depending on whether they refer to actions that are allowed or disallowed. Our model is expressive enough to capture naturally many notions of privacy found in legislation, including those found in HIPAA, COPPA, and GLBA. A number of important problems regarding compliance with privacy norms, future requirements associated with specific actions, and relations between policies and legal standards reduce to standard decision procedures for temporal logic.
Essential complicity of perforin-granzyme and FAS-L mechanisms to achieve tumor rejection following treatment with anti-CD137 mAb (2013)

CD137-elicited rejection of EG7-derived tumors involves the interplay of at least two final effector cytolytic mechanisms that act in cooperation.
Comment on “Quantum Interferometric Optical Lithography: Exploiting Entanglement to Beat the Diffraction Limit” (2001)

A Comment on the Letter by Agedi N. Boto, et al., Phys. Rev. Lett. 85, 2733 (2000).Received 18 October 2000DOI:https://doi.org/10.1103/PhysRevLett.86.1389©2001 American Physical Society
A potential and ion switched molecular photonic logic gate (2005)

A molecular photonic logic gate is demonstrated by integrating electrical (potential) and chemical (ionic) switching functions into molecules attached at an externally addressable semiconductor substrate.
Statistical static capacity management in virtualized data centers supporting fine grained QoS specification (2010)

From an ecological but also from an economical and in the meantime a technical view the fast ongoing increase of power consumption in today's data centers is no longer feasible. Methodologies, more efficiently using energy in data centers, must be developed. One step into this direction is to increase the utilization of the hardware in data centers by using virtualization techniques. The efficiency of such techniques strongly depends on provisioning and allocating the resources. Statistical static allocation approaches have been proven to use resources very efficiently by overbooking hardware using the fact that typical applications rarely need their maximum demand and especially seldom all at the same time. In our work we analyze these approaches and point out two major drawbacks. First, we show that guaranteeing QoS (Quality of Service) aspects by two parameters, as it is done in these approaches, is inflexible and often leads to suboptimal solutions. Second, such conventional approaches require statistical independent resource demands of the virtual machines which prevent them from being used in most common data centers. To overcome these drawbacks, we first suggest a more fine grained way of specifying QoS guarantees that saved up to 20% of resources to be reserved for a single virtual machine in our examples. Furthermore, we present a new allocation approach that is able to deal with any kind of correlations in the resource demand. Compared to a pessimistic approach, that reserves the maximum required resources for each virtual machines all over the time, our approach can save 27% of required hardware resources in a typical data center scenario.
Preparations and structures of two cis,cis-1,3,5-triaminocyclohexane-based complexes containing hydrogen-bonded solvent molecules (1996)

Reactions of cis,cis-1,3,5-tri-(E,E)-cinnamylideneaminocyclohexane and the new molecule cis,cis-1,3,5-tri-(E,E)-3-(2-furyl)prop-2-en-1-ylideneaminocyclohexane with diacetatonickel(II) hydrate and bis(tetrafluoroborato)cobalt(II) hydrate respectively afforded two novel metal complexes, the crystal structures of which showed chains of hydrogen-bonded solvent molecules within a rigid hydrophobic cavity.
A Bio-Impedance Readout IC With Digital-Assisted Baseline Cancellation for Two-Electrode Measurement (2019)

The measurement of the tissue or bio-impedance (BIOZ) is a safe and power-efficient sensing modality that can be adopted for the acquisition of vital signals, such as respiration and heartbeat. A BIOZ readout IC with a wide-input impedance range is proposed. The IC supports vital signal acquisition through a two-electrode setup which requires a larger dynamic range than the conventional four-electrode setup. A digital-assisted baseline impedance cancellation method is implemented to measure small tissue impedance variations originating from respiration and heartbeat in the presence of larger baseline impedances. The proposed technique also mitigates the input-dependent noise behavior of the readout front-end by minimizing the effective input signal to the instrumentation amplifier (IA). The baseline cancellation loop further improves the noise performance by cancelling the reference current noise from the current generator (CG). Hence, one single solution—baseline cancellation—resolves two issues facilitating two-electrode BIOZ setups achieving similar impedance resolution performance compared with more four-electrode setups. The IC, fabricated in a 55-nm CMOS, can measure tissue impedances over a frequency range from 1 kHz to 1 MHz and can achieve a maximum input range of 24 <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\text{k}\Omega $ </tex-math></inline-formula> (at the impedance measurement frequency) and a best-case resolution of 2 <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\text{m}\Omega $ </tex-math></inline-formula> RMS (for a 100- <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\Omega $ </tex-math></inline-formula> input). This increases to 14.0 <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\text{m}\Omega $ </tex-math></inline-formula> RMS for a 2- <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\text{k}\Omega $ </tex-math></inline-formula> input impedance. The ASIC consumes 18.9–34.9 and 31.4–154.7 <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\mu \text{W}$ </tex-math></inline-formula> for the readout front-end and the CG, respectively. The power depends on the injected current amplitudes. A successful demonstration on the human body through a two-electrode (gel and dry) setup confirms the effectivity of the proposed work in a real use case.
Kinetics of Hydrothermal Decomposition of Potassium Feldspar with Calcium Hydroxide (2012)

The aegirine-augite syenite potash ore, taken from Changling, Luonan in Shannxi province, were hydrothermally decomposed over the temperature ranges of 533 K to 563 K using calcium hydroxide as additive. The dissolution ratio of the K2O at different reaction temperature and time was determined. Analysis of the experimental results revealed that the dissolution rate of potash ore satisfies the chemical reaction controlled kinetic equation. The rate constant of hydrothermal reaction at different temperatures was obtained. The activation energy was calculated using the Arrhenius equation. The hydrothermal decomposition mechanism of microcline was proposed.
Mathematical modeling of translation initiation for the estimation of its efficiency to computationally design mRNA sequences with desired expression levels in prokaryotes (2010)

We herein describe a mathematical model that uses mRNA sequence information to estimate translational efficiency. This model could be used to design best-fit mRNA sequences having a desired protein expression level, thereby facilitating protein over-production in biotechnology or the protein expression-level optimization necessary for the construction of robust networks in synthetic biology.
Population Genetics Study of Isoniazid Resistance Mutations and Evolution of Multidrug-Resistant <i>Mycobacterium tuberculosis</i> (2006)

The molecular basis for isoniazid resistance in Mycobacterium tuberculosis is complex. Putative isoniazid resistance mutations have been identified in katG, ahpC, inhA, kasA, and ndh. However, small sample sizes and related potential biases in sample selection have precluded the development of statistically valid and significant population genetic analyses of clinical isoniazid resistance. We present the first large-scale analysis of 240 alleles previously associated with isoniazid resistance in a diverse set of 608 isoniazid-susceptible and 403 isoniazid-resistant clinical M. tuberculosis isolates. We detected 12 mutant alleles in isoniazid-susceptible isolates, suggesting that these alleles are not involved in isoniazid resistance. However, mutations in katG, ahpC, and inhA were strongly associated with isoniazid resistance, while kasA mutations were associated with isoniazid susceptibility. Remarkably, the distribution of isoniazid resistance-associated mutations was different in isoniazid-monoresistant isolates from that in multidrug-resistant isolates, with significantly fewer isoniazid resistance mutations in the isoniazid-monoresistant group. Mutations in katG315 were significantly more common in the multidrug-resistant isolates. Conversely, mutations in the inhA promoter were significantly more common in isoniazid-monoresistant isolates. We tested for interactions among mutations and resistance to different drugs. Mutations in katG, ahpC, and inhA were associated with rifampin resistance, but only katG315 mutations were associated with ethambutol resistance. There was also a significant inverse association between katG315 mutations and mutations in ahpC or inhA and between mutations in kasA and mutations in ahpC. Our results suggest that isoniazid resistance and the evolution of multidrug-resistant strains are complex dynamic processes that may be influenced by interactions between genes and drug-resistant phenotypes.
Practical Access to 2-Alkylsuccinates through Asymmetric Catalytic Hydrogenation of Stobbe-Derived Itaconates (1998)

Enantiomerically pure 2-alkylsuccinates are obtained on a 500-g scale after hydrogenation with the cationic rhodium complexes with tetraalkyl-substituted 1,2-bis(phospholanyl)ethane or -benzene ligands [R′-DuPHOS; Eq. (a)]. The catalysts allow smooth hydrogenation of mixtures of the prochiral E and Z isomers of itaconate derivatives with very high enantioselectivities and catalytic efficiencies; even tetrasubstituted itaconates were hydrogenated with 96% ee.
SUBMICRON MAGNETIC PARTICLE SEPARATION (1985)

ABSTRACT The control, collection or separation of particles on the basis of Their magnetic moment relative Co the carrier fluid has been demonstrated in many applications. Usually the particle sizes are larger than one micron and the magnetic susceptibility at least moderately paramagnetic. Recently, particle separation techniques have been developed for both diamagnetic and submicron particles. These techniques have found application in mineral beneficiation, nuclear reactor coolants, biology and medicine. Such developments require an understanding of flow forces in liquids and gases, diffusion and Brownian motion, and of magnetic properties which range from the strong magnetic moments of ferromagnetic and superparamagnetic particles down orders of magnitude to those of diamagnetism.
Pronounced Effect of DNA Hybridization on Click Reaction Efficiency (2007)

Abstract We report about the efficiency of the click reaction directly on PCR products containing alkyne‐modified uridine nucleosides. Galactose azide was clicked onto single‐stranded and double‐stranded 300mer DNA in order to investigate the efficiency of sugar labeling of DNA under various conditions. Single‐stranded alkyne‐modified DNA was prepared by selective lambda exonuclease digestion of 5′‐phosphate‐labeled double strands. A comparison of the click reaction efficiency on modified single and double stranded 300mers under identical conditions shows a pronounced effect of the strandedness on the yield of the click reaction.
Correlation of the Sweetness of Variants of the Protein Brazzein with Patterns of Hydrogen Bonds Detected by NMR Spectroscopy (2003)

In sequence-function investigations, approaches are needed for rapidly screening protein variants for possible changes in conformation. Recent NMR methods permit direct detection of hydrogen bonds through measurements of scalar couplings that traverse hydrogen bonds (trans-hydrogen bond couplings). We have applied this approach to screen a series of five single site mutants of the sweet protein brazzein with altered sweetness for possible changes in backbone hydrogen bonding with respect to wild-type. Long range, three-dimensional data correlating connectivities among backbone 1HN, 15N, and 13C' atoms were collected from the six brazzein proteins labeled uniformly with carbon-13 and nitrogen-15. In wild-type brazzein, this approach identified 17 backbone hydrogen bonds. In the mutants, altered magnitudes of the couplings identified hydrogen bonds that were strengthened or weakened; missing couplings identified hydrogen bonds that were broken, and new couplings indicated the presence of new hydrogen bonds. Within the series of brazzein mutants investigated, a pattern was observed between sweetness and the integrity of particular hydrogen bonds. All three "sweet" variants exhibited the same pattern of hydrogen bonds, whereas all three "non-sweet" variants lacked one hydrogen bond at the middle of the alpha-helix, where it is kinked, and one hydrogen bond in the middle of beta-strands II and III, where they are twisted. Two of the non-sweet variants lack the hydrogen bond connecting the N and C termini. These variants showed greater mobility in the N- and C-terminal regions than wild-type brazzein.
Childhood Asthma (1996)

The effective management of asthma involves careful attention to family education and environmental, psychological and other triggers. However, the majority of patients will require drug treatment. The only bronchodilators in common use are β2-agonists and theophylline. In young children, the choice of an appropriate drug delivery system will frequently determine the choice of medication. For anti-inflammatory therapy, it seems prudent to adhere to the recommendation that children should be started on sodium cromoglycate (cromolyn sodium), and to use inhaled corticosteroids only when sodium cromoglycate has been unsuccessful. Although inhaled corticosteroids are absorbed systemically, their toxicity is limited and their benefits are more apparent than their adverse effects. An acute attack of asthma should be regarded as a failure of prophylactic treatment, and is an indication to review interval management.
THRESHOLD GRADIENT FOR WATER FLOW IN CLAY-WATER SYSTEMS (1962)

Abstract not available
Genomic Structures and Characterization of Rael Family Members Encoding GPI-Anchored Cell Surface Proteins and Expressed Predominantly in Embryonic Mouse Brain (1996)

Rae1 alpha, Rae1 beta, and Rae1 gamma cDNAs isolated from retinoic acid-treated mouse embryonal carcinoma F9 cells encode cell surface proteins sharing partial homology with MHC class I molecules, and mRNAs corresponding to these cDNAs were detected exclusively in early mouse embryos, especially in the head region. To initiate studies on their roles, the rae1 alpha gene and the genomic DNAs covering the complete coding regions of the rae1 beta and rae1 gamma genes were isolated and their structures were analyzed. Although the coding regions of the three rae1 genes were highly homologous, the restriction map of the 5'-end region of the rae1 alpha gene differed from that of the rae1 beta and rae1 gamma genes. The rae1 family members were mapped by FISH on mouse chromosome 10A4 region. Genomic DNAs hybridizable with a Rae1 cDNA were not detected in rat and human. Rae1 genes were preferentially expressed in early mouse embryos, preferentially in the brain, and RAE1 proteins were anchored on the cell surface by a glycosyl phosphatidylinositol (GPI)-tail, a feature shared by important cell surface ligands.
Chrono-coherent imaging for medicine (1989)

Imaging inside the body with optical wavelengths encounters problems due to light scattering of tissues and other optical distortions. A description is given of chrono-coherent imaging (CCI), a new method for imaging with visible and near-infrared light that uses coherent image formation and subpicosecond timing to remove the time-delayed scattered light. With CCI it is possible to form images in the presence of the overwhelming amount of scattered light that blocks conventional image formation. The coherent image formation process allows the use of long-duration, high-total-energy, and modest-peak-power pulses to overcome scattering losses. CCI is an extension of light-in-flight holography, which combines the properties of short-duration pulses and hologaphy for various measurements of objects and optical wavefronts.
Inhibition of mRNA translation extends lifespan in <i>Caenorhabditis elegans</i> (2006)

Protein synthesis is a regulated cellular process that links nutrients in the environment to organismal growth and development. Here we examine the role of genes that regulate mRNA translation in determining growth, reproduction, stress resistance and lifespan. Translational control of protein synthesis by regulators such as the cap-binding complex and S6 kinase play an important role during growth. We observe that inhibition of various genes in the translation initiation complex including ifg-1, the worm homologue of eIF4G, which is a scaffold protein in the cap-binding complex; and rsks-1, the worm homologue of S6 kinase, results in lifespan extension in Caenorhabditis elegans. Inhibition of ifg-1 or rsks-1 also slows development, reduces fecundity and increases resistance to starvation. A reduction in ifg-1 expression in dauers was also observed, suggesting an inhibition of protein translation during the dauer state. Thus, mRNA translation exerts pleiotropic effects on growth, reproduction, stress resistance and lifespan in C. elegans.