gebhart/patrepeval huggingface dataset:
Road scene monotony detection in a fatigue management driver assistance system (2005)

Automated fatigue detection devices show much promise in combating fatigue related accidents. One aspect which hampers the introduction of these technologies is context awareness. In this paper we develop and evaluate a road scene monotony detector. The detector can be used to give context awareness to fatigue detection tools to minimise false positives. The approach could also be used by road makers to quantify monotony on fatigue prone stretches of road. The detector uses MPEG compression to measure the change in information content of the road scene over time. We show that the detector correlates highly with human identified monotonous scenes. The technique is consistent over time and applicable for day and night operation. The compression is augmented with lane tracking data to distinguish between otherwise difficult cases. The detector is integrated into a fatigue management driver assistance system.
Epigenetic Modulating Agents as a New Therapeutic Approach in Multiple Myeloma (2013)

Multiple myeloma (MM) is an incurable B-cell malignancy. Therefore, new targets and drugs are urgently needed to improve patient outcome. Epigenetic aberrations play a crucial role in development and progression in cancer, including MM. To target these aberrations, epigenetic modulating agents, such as DNA methyltransferase inhibitors (DNMTi) and histone deacetylase inhibitors (HDACi), are under intense investigation in solid and hematological cancers. A clinical benefit of the use of these agents as single agents and in combination regimens has been suggested based on numerous studies in pre-clinical tumor models, including MM models. The mechanisms of action are not yet fully understood but appear to involve a combination of true epigenetic changes and cytotoxic actions. In addition, the interactions with the BM niche are also affected by epigenetic modulating agents that will further determine the in vivo efficacy and thus patient outcome. A better understanding of the molecular events underlying the anti-tumor activity of the epigenetic drugs will lead to more rational drug combinations. This review focuses on the involvement of epigenetic changes in MM pathogenesis and how the use of DNMTi and HDACi affect the myeloma tumor itself and its interactions with the microenvironment.
Mitochondrial p38β and Manganese Superoxide Dismutase Interaction Mediated by Estrogen in Cardiomyocytes (2014)

This work demonstrates for the first time a mitochondrial pool of active p38β and E2-mediated phosphorylation of MnSOD by the kinase. The results shed light on the mechanism behind the cytoprotective actions of E2 in cardiomyocytes under oxidative stress.
Evaluation of the variance function for edge enhancement in multidimensional data (2003)

A multidimensional variance function filter is defined and its performance in edge enhancement applications is evaluated. For the case of a 3*3 window, the variance filter is shown to perform comparably to the Sobel filter and better than the compass gradient filter. The advantage of the variance filter is its easy extendability to large window sizes and high dimensionality. The 3D variance filter is applied to the ventricular edge detection problem in gated nuclear cardiac imaging.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
High-level transcription of the major Bacillus subtilis autolysin operon depends on expression of the sigma D gene and is affected by a sin (flaD) mutation (1993)

Transcription of the major Bacillus subtilis autolysin gene (cwlB) was investigated. Deletion of the region upstream of the gene cluster lppX-cwbA-cwlB led to a loss of promoter activity. Primer extension analysis suggested that the cwlB operon is transcribed by E sigma D and E sigma A, the former transcripts being predominants at the exponential growth phase. Expression of the lppX-lacZ fusion gene was reduced by about 90% in a sigD-null mutant. A sin (flaD1) mutation caused a severe defect in transcription of the lppX-cwbA-cwlB operon. The sin (flaD1) mutation also reduced expression of a sigD-lacZ fusion gene constructed in the B. subtilis chromosome. Since the sigD-null mutant exhibits motility and autolysin deficiencies and filamentation, similar phenotypes in the sin (flaD1) mutant may be caused by reduction in expression of the sigma D protein.
Modulation of Ca <sup>2+</sup> entry by polypeptides of the inositol 1,4,5-trisphosphate receptor (IP3R) that bind transient receptor potential (TRP): Evidence for roles of TRP and IP3R in store depletion-activated Ca <sup>2+</sup> entry (1999)

Homologues of Drosophilia transient receptor potential (TRP) have been proposed to be unitary subunits of plasma membrane ion channels that are activated as a consequence of active or passive depletion of Ca(2+) stores. In agreement with this hypothesis, cells expressing TRPs display novel Ca(2+)-permeable cation channels that can be activated by the inositol 1,4,5-trisphosphate receptor (IP3R) protein. Expression of TRPs alters cells in many ways, including up-regulation of IP3Rs not coded for by TRP genes, and proof that TRP forms channels of these and other cells is still missing. Here, we document physical interaction of TRP and IP3R by coimmunoprecipitation and glutathione S-transferase-pulldown experiments and identify two regions of IP3R, F2q and F2g, that interact with one region of TRP, C7. These interacting regions were expressed in cells with an unmodified complement of TRPs and IP3Rs to study their effect on agonist- as well as store depletion-induced Ca(2+) entry and to test for a role of their respective binding partners in Ca(2+) entry. C7 and an F2q-containing fragment of IP3R decreased both forms of Ca(2+) entry. In contrast, F2g enhanced the two forms of Ca(2+) entry. We conclude that store depletion-activated Ca(2+) entry occurs through channels that have TRPs as one of their normal structural components, and that these channels are directly activated by IP3Rs. IP3Rs, therefore, have the dual role of releasing Ca(2+) from stores and activating Ca(2+) influx in response to either increasing IP3 or decreasing luminal Ca(2+).
A Preliminary Report on the Use of Bench-Top X-Ray Micro-Computerised Tomography to Study the Malpighian Tubules of the Overwintering Seven Spotted Ladybird<i>Coccinella septempunctata</i>L. (Coleoptera: Coccinellidae) (2012)

The application of micro-CT scanning techniques on a small sample of “Seven-spot ladybirds” Coccinella septempunctata, collected in December 2009, identified an accumulation of material with a very high, relative X-ray attenuation value in the malpighian tubules of most but not all of the individuals sampled. The passage of metals such as cadmium in soil through a food chain to finally accumulate in high concentrations in ladybirds and lacewings has been previously reported. The identification of the dense material found in our sample of ladybirds, its origin, and the process by which it accumulates in, and is processed by, the malpighian tubules is the challenge ahead. The authors speculate that a straightforward means of monitoring levels of metallic pollutants in the environment might emerge.
Fusion Approach for Fingerprint Matching for Improved System Accuracy (2011)

In automated fingerprint identification systems, an efficient and accurate alignment algorithm in the preprocessing stage plays a crucial role in the performance of the whole system, affecting greatly the speed and accuracy otherwise. This paper proposes a fusion scheme (weighted sum) for aligning the enrolled and query images using modified ring model and cross correlation approaches. Both the methods align the pair of fingerprint images based on the single singular point (as a reference point). Matching is then performed using Euclidean distance based matcher. This model is tested on both publicly available (Cross Match Verifier 300 sensor) as well as proprietary (Lumidigm Venus V100 OEM Module sensor) fingerprint databases scanned at 500 dpi. The experiments show that this fusion approach improves the overall system accuracy: FNMR and FMR significantly dropped to 3.23 % &amp; 2.67% respectively for Cross Match Dataset and 0 % &amp; 1.33% respectively for Lumidigm Dataset. Hence, the combination of these two alignment methods effectively strengthens the performance of the matcher.
Interaction of toxic venoms with the complement system. (1971)

Thirty-nine venoms from various vertebrate and invertebrate species were tested for their ability to consume haemolytic complement (C) activity upon incubation in fresh guinea-pig serum. Nineteen had `anti-complementary' activity, and these were provisionally sorted into the following groups: Pattern I—exemplified by the Naja haje (Egyptian cobra) and six other Elapidae species (all cobras), which induced selective consumption of C3—C9, and led to formation of a stable C3—C9-consuming intermediate; Pattern II—exemplified by the Agkistrodon rhodostoma (Malayan pit viper), Bitis arietans (puff adder), Bothrops jararaca (South American pit viper), Bothrops atrox (Fer de Lance) and three other species, which induced marked consumption of C4 and C2, as well as C3—C9, but did not form a stable C3—C9-consuming intermediate; and individual animals, e.g. the Lachesis muta (bushmaster), which induced other patterns (III—VI) of complement component consumption. Active fractions of representative venoms were partially purified by ion exchange and gel filtration chromatography and their interactions with the complement system characterized further. It is anticipated that these enzymes, with a capacity to activate the complement system in unique ways, will prove to be of further experimental usefulness.
Methionyl-tRNA synthetase from<i>Bacillus stearothermophilus</i>: structural and functional identities with the<i>Escherichia coli</i>enzyme (1991)

The metS gene encoding homodimeric methionyl-tRNA synthetase from Bacillus stearothermophilus has been cloned and a 2880 base pair sequence solved. Comparison of the deduced enzyme protomer sequence (Mr 74,355) with that of the E. coli methionyl-tRNA synthetase protomer (Mr 76,124) revealed a relatively low level (32%) of identities, although both enzymes have very similar biochemical properties (Kalogerakos, T., Dessen, P., Fayat, G. and Blanquet, S. (1980) Biochemistry 19, 3712-3723). However, all the sequence patterns whose functional significance have been probed in the case of the E. coli enzyme are found in the thermostable enzyme sequence. In particular, a stretch of 16 amino acids corresponding to the CAU anticodon binding site in the E. coli synthetase structure is highly conserved in the metS sequence. The metS product could be expressed in E. coli and purified. It showed structure-function relationships identical to those of the enzyme extracted from B. stearothermophilus cells. In particular, the patterns of mild proteolysis were the same. Subtilisin converted the native dimer into a fully active monomeric species (62 kDa), while trypsin digestion yielded an inactive form because of an additional cleavage of the 62 kDa polypeptide into two subfragments capable however of remaining firmly associated. The subtilisin cleavage site was mapped on the enzyme polypeptide, and a gene encoding the active monomer was constructed and expressed in E. coli. Finally, trypsin attack was demonstrated to cleave a peptidic bond within the KMSKS sequence common to E. coli and B. stearothermophilus methionyl-tRNA synthetases. This sequence has been shown, in the case of the E. coli enzyme, to have an essential role for the catalysis of methionyl-adenylate formation.
Q-switch-pumped supercontinuum for ultra-high resolution optical coherence tomography (2017)

In this Letter, we investigate the possibility of using a commercially available Q-switch-pumped supercontinuum (QS-SC) source, operating in the kilohertz regime, for ultra-high resolution optical coherence tomography (UHR-OCT) in the 1300 nm region. The QS-SC source proves to be more intrinsically stable from pulse to pulse than a mode-locked-based SC (ML-SC) source while, at the same time, is less expensive. However, its pumping rate is lower than that used in ML-SC sources. Therefore, we investigate here specific conditions to make such a source usable for OCT. We compare images acquired with the QS-SC source and with a current state-of-the-art SC source used for imaging. We show that comparable visual contrast obtained with the two technologies is achievable by increasing the readout time of the camera to include a sufficient number of QS-SC pulses.
30-GHz-Band Periodic Branching Filter Using a Traveling-Wave Resonator for Satellite Applications (1977)

A periodic branching filter consisting of three directional couplers, a traveling-wave resonator, and connecting waveguides is used as a band diplexer with a broad 3-dB bandwidth and sharp selectivity for a satellite communication system application. This paper describes a theoretical analysis, a design method, and experimental results for this periodic branching filter. The fabricated periodic branching filter for separating the 30-GHz frequency band 27.0-29.2 GHz into two subbands of equal 3-dB bandwidth of about 900 MHz has sharp frequency selectivity. Measured branching losses and relative delay time are 0.35-0.5 dB and 0.4 ns, respectively, within each frequency subband (f /sub 1,2/ /spl plusmn/ 300 MHz). The 96-g diplexer is made of thin-walled aluminum. Its size is 15 x 9 x 4 cm.
Three‐Dimensional Quantitative Structure–Activity Relationship Studies on c‐Src Inhibitors Based on Different Docking Methods (2009)

c-Src kinase play an important role in cell growth and differentiation and its inhibitors can be useful for the treatment of various diseases, including cancer, osteoporosis, and metastatic bone disease. Three dimensional quantitative structure-activity relationship (3D-QSAR) studies were carried out on quinazolin derivatives inhibiting c-Src kinase. Molecular field analysis (MFA) models with four different alignment techniques, namely, GLIDE, GOLD, LIGANDFIT and Least squares based methods were developed. glide based MFA model showed better results (Leave one out cross validation correlation coefficient r(2)(cv) = 0.923 and non-cross validation correlation coefficient r(2)= 0.958) when compared with other models. These results help us to understand the nature of descriptors required for activity of these compounds and thereby provide guidelines to design novel and potent c-Src kinase inhibitors.
Polyester amides from linseed oil for protective coatings (1966)

Abstract The sodium alkoxide‐catalyzed reaction of linseed oil or linseed methyl esters with diethanolamine produces almost exclusively linseed diethanolamides. Reaction conditions, e.g., temperature, amount of excess diethanolamine and mode of adding reactants, are reported. The best conditions for producing diethanolamide directly from linseed oil (1 mole) required adding oil to the sodium alkoxide in diethanolamine (6 moles) and heating at 110舑115C for 35 min. The linseed diethanolamide isolated in 93舑95% yield was an amber oil. Progress of the reaction, followed by thin‐layer chromatography, showed only trace amounts of byproducts. Polyester amides were prepared by heating linseed diethanolamide in refluxing xylene with dibasic acids or anhydrides, e.g., azelaic, maleic, fumaric, phthalic, terephthalic, itaconic, brassylic and dimer acids. Molecular weight, viscosity and film properties (air‐dried and baked) of the polyester amides were determined.
Efficient complex operators for irregular codes (2011)

Complex “fat operators” are important contributors to the efficiency of specialized hardware. This paper introduces two new techniques for constructing efficient fat operators featuring up to dozens of operations with arbitrary and irregular data and memory dependencies. These techniques focus on minimizing critical path length and load-use delay, which are key concerns for irregular computations. Selective Depipelining(SDP) is a pipelining technique that allows fat operators containing several, possibly dependent, memory operations. SDP allows memory requests to operate at a faster clock rate than the datapath, saving power in the datapath and improving memory performance. Cachelets are small, customized, distributed L0 caches embedded in the datapath to reduce load-use latency. We apply these techniques to Conservation Cores(c-cores) to produce coprocessors that accelerate irregular code regions while still providing superior energy efficiency. On average, these enhanced c-cores reduce EDP by 2× and area by 35% relative to c-cores. They are up to 2.5× faster than a general-purpose processor and reduce energy consumption by up to 8× for a variety of irregular applications including several SPECINT benchmarks.
The correlation between morphological and phylogenetic classification of myxobacteria (1999)

In order to determine whether morphological criteria are suitable to affiliate myxobacterial strains to species, a phylogenetic analysis of 16S rDNAs was performed on 54 myxobacterial strains that represented morphologically 21 species of the genera Angiococcus, Archangium, Chondromyces, Cystobacter, Melittangium, Myxococcus, Polyangium and Stigmatella, five invalid species and three unclassified isolates. The analysis included 12 previously published sequences. The branching pattern confirmed the deep trifurcation of the order Myxococcales. One lineage is defined by the genera Cystobacter, Angiococcus, Archangium, Melittangium, Myxococcus and Stigmatella. The study confirms the genus status of 'Corallococcus', previously 'Chondrococcus', within the family Myxococcaceae. The second lineage contains the genus Chondromyces and the species Polyangium ('Sorangium') cellulosum, while the third lineage is comprised of Nannocystis and a strain identified as Polyangium vitellinum. With the exception of a small number of strains that did not cluster phylogenetically with members of the genus to which they were assigned by morphological criteria ('Polyangium thaxteri' Pl t3, Polyangium cellulosum ATCC 25531T, Melittangium lichenicola ATCC 25947T and Angiococcus disciformis An d1), the phenotypic classification should provide a sound basis for the description of neotype species in those cases where original strain material is not available or is listed as reference material.
Fast speaker change detection for broadcast news transcription and indexing (1999)

In this paper, we describe a new speaker change detection algorithm designed for fast transcription and audio indexing of spoken broadcast news. We have designed a two-stage algorithm that begins with a gender-independent phone-class recognition pass. We collapse the phoneme inventory to only 4 broad classes and include 4 different models for non-speech, resulting in a small fast decoder that runs in less than 0.1 times real-time. The second stage of the SCD algorithm hypothesizes a speaker change boundary between every phone in the labeled input. The phone level time resolution in our approach permits the algorithm to run quickly while maintaining the same accuracy as a frame level approach. Applying the new algorithms to a large sample of broadcast news programs resulted in improvements in speaker change detection accuracy, speech recognition accuracy, and speed.
Respiratory Syncytial Virus (RSV)–Induced Airway Hyperresponsiveness in Allergically Sensitized Mice Is Inhibited by Live RSV and Exacerbated by Formalin‐Inactivated RSV (2000)

Respiratory syncytial virus (RSV)-induced disease is associated with recurrent episodes of wheezing in children, and an effective vaccine currently is not available. The use of 2 immunizations (a formalin-inactivated, alum-precipitated RSV vaccine [FI-RSV] given intramuscularly and live RSV given intranasally [LVIN]), with a control immunization, were compared in a well-characterized model of RSV challenge, with or without concomitant allergic sensitization with ovalbumin. FI-RSV caused a significant increase in airway hyperresponsiveness in mice after RSV infection during allergic sensitization, and this was associated with an increase in type 2 cytokine production. In contrast, immunization with LVIN did not change type 2 cytokine production and protected against RSV-induced airway hyperresponsiveness in the setting of allergic sensitization. This study suggests that immune modulation with RSV vaccination can have profound effects on RSV-induced airway disease and that prevention of airway hyperresponsiveness is an important end point in vaccine development.
SOR1, a gene associated with bioherbicide production in sorghum root hairs (2004)

Sorghum [Sorghum bicolor (L.) Moench] roots exude a potent bioherbicide known as sorgoleone, which is produced in living root hairs and is phytotoxic to broadleaf and grass weeds at concentrations as low as 10 microM. Differential gene expression was studied in sorghum (S. bicolorxS. sudanense) cv. SX17 between roots with abundant root hairs and those without root hairs using a modified differential display approach. A differentially expressed gene, named SOR1, was cloned by using Rapid Amplification of the 5' ends of cDNA (5'-RACE). Real-time PCR analysis of multiple tissues of sorghum SX17 revealed that the SOR1 transcript level in root hairs was more than 1000 times higher than that of other tissues evaluated, including immature leaf, mature leaf, mature stem, panicle, and roots with hairs removed. Semi-quantitative RT-PCR revealed that SOR1 was expressed in the sorgoleone-producing roots of sorghum SX17, shattercane [S. bicolor (L.) Moench], and johnsongrass [S. halepense (L.) Pers.], but not in the shoots of sorghum or in the roots of sweet corn (Zea mays L.) 'Summer Flavor 64Y', in which sorgoleone production was not detected by HPLC analysis. Similarity searches indicated that SOR1 probably encodes a novel desaturase, which might be involved in the formation of a unique and specific double bonding pattern within the long hydrocarbon tail of sorgoleone.
Block of human cardiac Kv1.5 channels by loratadine: voltage-, time- and use-dependent block at concentrations above therapeutic levels (1997)

The present results demonstrated that loratadine blocked hKv1.5 channels in a concentration-, voltage-, time- and use-dependent manner but only at concentrations much higher than therapeutic plasma levels in man.
Co-transduction of herpes simplex virus thymidine kinase gene and human interleukin-2 gene into mouse ovarian cancer cell line, OVHM. (2000)

We studied the thymidine kinase (TK) gene and the interleukin (IL)-2 gene co-transduction into tumor cells for a possible strategy of cancer gene therapy. A murine ovarian cancer cell line, OVHM, was retrovirally transduced with the TK (OVHM/TK) or the IL-2 gene (OVHM/IL-2). The TK or IL-2 expression was permanent in OVHM/TK or OVHM/IL-2. OVHM/TK cells were susceptible to gancyclovir (GCV) in vitro, and their intraperitoneal growth was completely regulated with GCV administration. The bystander effect was not observed in vitro and in vivo in this model, and only the marginal emergence of immune involvement was observed in the OVHM/TK-cured mice with GCV. OVHM/IL-2 cells produced IL-2 biologically active to be immunogenic, but still tumorigenic to kill the mice when inoculated intraperitoneally. Then, OVHM/TK cells were co-transduced with the IL-2 gene to establish OVHM/TK/IL-2 cells. OVHM/TK/IL-2 cells were also susceptible to GCV and transiently produced active IL-2. A significant resistance against the challenge of parental tumor cells was observed in the mice that were inoculated with OVHM/TK/IL-2 cells and cured with GCV administration. It is suggested that tumor cells transduced with both TK and IL-2 genes could be regressed with GCV administration with subsequent generation of immune activation in the host. Since the bystander effect may not always be a common phenomenon in gene therapy using the TK gene, this type of combination may be advantageous in the clinical application of gene therapy for human cancers.