gebhart/patrepeval huggingface dataset:
Dynamic Performance of a Squeeze Film Damper with a Cylindrical Roller Bearing under a Large Static Radial Loading Range (2019)

Turbomachine rotors, supported by little damped rolling element bearings, are generally sensitive to unbalance excitation. Accordingly, most machines incorporate squeeze film damper technology to dissipate mechanical energy caused by rotor vibrations and to ensure stable operation. When developing a novel geared turbomachine able to cover a large power range, a uniform mechanical drivetrain needs to perform well over the large operational loading range. Especially, the rotor support, containing a squeeze film damper and cylindrical roller bearing in series, is of vital importance in this respect. Thus, the direct objective of this research project was to map the performance of the envisioned rotor support by estimating the damping ratio based on the simulated and measured vibration response during run-up. An academic test rig was developed to provide an in-depth analysis on the key components in a more controlled setting. Both the numerical simulation and measurement results exposed severe vibration problems for an insufficiently radial loaded bearing due to a pronounced anisotropic bearing stiffness. As a result, a split first whirl mode arose with its backward component heavily triggered by the synchronous unbalance excitation. Hence, the proposed SFD does not function properly in the lower radial loading range. Increasing the static load on the bearing or providing a modified rotor support for the lower power variants will help mitigating the vibration issues.
Dietary Fiber, Glycemic Load, and Risk of Non—insulin-dependent Diabetes Mellitus in Women (1997)

Our results support the hypothesis that diets with a high glycemic load and a low cereal fiber content increase risk of diabetes in women. Further, they suggest that grains should be consumed in a minimally refined form to reduce the incidence of diabetes.
Topical Review : Neurologic Aspects of Adenylosuccinate Lyase Deficiency (2001)

Adenylosuccinate lyase deficiency is an autosomal-recessive disorder of the purine de novo synthesis pathway, diagnosed up to now in approximately 40 patients. The clinical presentation is characterized by severe neurologic involvement including seizures, developmental delay, hypotonia, and autistic features. Neonatal seizures and a severe infantile epileptic encephalopathy are often the first manifestations of this disorder. The existence of genetic heterogeneity for the adenylosuccinate lyase defect could account for variability of the clinical presentation. Deficiency of purine nucleotides, impairment of energy metabolism, and toxic effects are potential mechanisms of cerebral damage. Laboratory investigations show the presence in urine and cerebrospinal fluid of succinylpurines, which are normally undetectable. Currently, no effective treatment is available for adenylosuccinate lyase deficiency. A search for this disorder should be included in the screening program of children with unexplained neonatal seizures or severe infantile epileptic encephalopathy.
A Systematic Approach toAccurate Evaluation ofCD-Metrology Tools (2007)

We present aprocedure forevaluating the accuracy andperformance ofcritical dimension (CD) II.SYSTEM DETAILS metrology tools usedinmonitoring thesemiconductorCentral toourevaluation approach isasample withaseries manufacturing process. Ourmethodinvolves areferenceofteststructures, called theAMAG5L (2). Thesample measurement instrument andSItraceable referenceincludes test structures suchascleavable lines, features for material toevaluate theaccuracy andresolution ofCD optical proximity correction (OPC), andvarious features for metrology tools. Theachievable accuracy andintrinsic evaluating boththeaccuracy andtheability ofthetool under linearity ofthetools undertest areevaluated withrespecttest (TuT) todetect small differences inthemeasurand. The tothereference system. different features onthesample allow ustoevaluate tools suchasCD-SEMs,scatterometers andCD-atomic force Index Terms-Atomic force microscope, Critical dimension, microscopes (AFMs). Table1lists someofthefeatures on Scanning electron microscope, Uncertainty, Accuracy. thesample AMAG andtheparameters theyevaluate. The specific feature useddepends onthetypeofinstrument being I.INTRODUCTION eautd
Purified prion proteins and scrapie infectivity copartition into liposomes. (1987)

Considerable evidence indicates that the scrapie prion protein (PrP 27-30) is required for infectivity. Aggregates of PrP 27-30 form insoluble amyloid rods that resist dissociation by nondenaturing detergents. Mixtures of the detergent cholate and phospholipids were found to solubilize purified PrP 27-30 in the form of detergent-lipid-protein complexes. Removal of the cholate by dialysis resulted in the formation of closed liposomes. Both the detergent-lipid-protein complexes and the liposomes often but not always exhibited a 10-fold increase in scrapie infectivity compared to that observed with the rods. No evidence for a prion-associated nucleic acid could be found when the phospholipid vesicles containing PrP 27-30 were digested with nucleases and Zn2+ under conditions that allowed hydrolysis of exogenously added nucleic acids. No filamentous or rod-shaped particles were found amongst prion liposomes by electron microscopy in our search for a putative filamentous "scrapie virus." The partitioning of PrP 27-30 and scrapie infectivity into phospholipid vesicles contends that PrP 27-30 has a central role in scrapie pathogenesis, establishes that the prion amyloid rods are not essential for infectivity, and argues that prions are fundamentally different from viruses.
Athletic Pubalgia and “Sports Hernia”: Optimal MR Imaging Technique and Findings (2008)

Groin injuries are common in athletes who participate in sports that require twisting at the waist, sudden and sharp changes in direction, and side-to-side ambulation. Such injuries frequently lead to debilitating pain and lost playing time, and they may be difficult to diagnose. Diagnostic confusion often arises from the complex anatomy and biomechanics of the pubic symphysis region, the large number of potential sources of groin pain, and the similarity of symptoms in athletes with different types or sites of injury. Many athletes with a diagnosis of "sports hernia" or "athletic pubalgia" have a spectrum of related pathologic conditions resulting from musculotendinous injuries and subsequent instability of the pubic symphysis without any finding of inguinal hernia at physical examination. The actual causal mechanisms of athletic pubalgia are poorly understood, and imaging studies have been deemed inadequate or unhelpful for clarification. However, a large-field-of-view magnetic resonance (MR) imaging survey of the pelvis, combined with high-resolution MR imaging of the pubic symphysis, is an excellent means of assessing various causes of athletic pubalgia, providing information about the location of injury, and delineating the severity of disease. Familiarity with the pubic anatomy and with MR imaging findings in athletic pubalgia and in other confounding causes of groin pain allows accurate imaging-based diagnoses and helps in planning treatment that targets specific pathologic conditions.
A functional simian virus 40 origin of replication is required for the generation of a super T antigen with a molecular weight of 100,000 in transformed mouse cells (1983)

We used two recombinant plasmids, one containing wild-type simian virus 40 DNA (pSVR1) and the other containing a simian virus 40 genome with a defective origin of replication (pSVR1-origin-minus) to transfect NIH3T3 cells. Quantitation of T-antigen synthesis by indirect immunofluorescence at 48 h after transfection with either DNA revealed the same percentage of T-positive nuclei. The transformation frequencies observed were also similar with both plasmids. Immunoprecipitation of [35S]methionine-labeled cell extracts showed the expected 94,000-dalton (94K) T and 17K t antigens in all clones examined. In pSVR1-generated transformants, a 100K super T antigen was also detected. Transformants isolated from pSVR1-origin-minus transfection, however, never expressed this 100K super T antigen, and some of these clones originally also showed greatly reduced levels of 94K T antigen. However, after growth in culture for several generations, the levels of 94K T antigen synthesis in these underproducer clones were dramatically increased. A direct correlation between the amounts of T antigen synthesized and the ability to grow independently of anchorage was observed. The mechanism which brings about increasing levels of T-antigen synthesis in some of the clones is not clear, but it appears not to be due to changes in either the copy number or the methylation pattern of the integrated simian virus 40 DNA.
Inflammation and restenosis after percutaneous coronary interventions (2004)

The role of inflammation in the development of restenosis after percutaneous coronary interventions has been investigated in several studies. There is an interaction of inflammatory activation and vascular wall response to injury leading to intimal hyperplasia. Percutaneous interventions trigger inflammatory reactions leading to the development of intimal hyperplasia. This reaction is even more prominent in atheromatic plaques in which inflammatory cells have already been activated. In the clinical setting there are several methods for the recognition of the inflammatory activation. In this article we review the data for the role of inflammatory process in restenosis and the significance of identifying the inflamed lesions prior to the intervention. Moreover, the therapeutic implications for the inhibition of inflammatory activation are mentioned.
Thermographic detection of disbonds (1989)

The presence of disbonds significantly decreases the integrity of many laminated structures used in aerospace applications. A thermographic technique is presented which is able to detect subsurface delamination. The technique uses one of several heat sources (such as hot water, hot air, IR lamps, etc.) to increase the surface temperature of the structure. The subsequent temperature profiles of the surface are detected with an IR camera. A novel spatial filter developed at NASA-Langley eliminates the effects of uneven heating to give clear images of the subsurface delaminations. Defects are detectable in samples as diverse as solid rocket motor samples and laminated wood for wind tunnel blades. Numerical simulations are presented for comparison with experiment results.
Classification problem solving (1984)

A broad range of heuristic programs--embracing forms of diagnosis, catalog selection, and skeletal planning--accomplish a kind of well-structured problem solving called classification. These programs have a characteristic interference structure that systematically relates data to a preenumerated set of solutions by abstraction, heuristic association, and refinement. This level of description specifies the knowledge needed to solve a problem, independent of its representation in a particular computer language. The classification problem-solving model provides a useful framework for recognizing and representing similar problems, for designing representation tools, and for understanding the problem-solving methods used by non-classification programs.
Illumination analysis for synthetic/natural hybrid image sequence generation (2002)

For virtual studio TV production, multi-site videoconference applications using a virtual meeting room and for synthetic/natural hybrid coding according to the forthcoming ISO/MPEG-4 standard, a synthetic and a natural scene are mixed to generate a synthetic/natural hybrid image sequence. For realism, the illumination in both scenes should be identical. The illumination of the natural scene is estimated automatically and applied to the synthetic scene. For illumination estimation, moving real objects are segmented in the natural image sequence and 3D modeled. The 3D shape, 3D motion and the displaced frame difference between two succeeding images are evaluated to estimate three illumination parameters. The parameters describe a distant point light source and ambient light. Using the estimated illumination parameters, the synthetic scene is rendered and mixed to the natural image sequence. Experimental results with a moving virtual ball mixed automatically into a real video telephone sequence show that virtual objects appear naturally having the same shading and shadows as the real person.
Microchip laser based on Yb:YAG/V:YAG monolith crystal (2016)

V:YAG crystal was investigated as a passive Q-switch of longitudinally diode-pumped microchip laser, emitting radiation at wavelength 1030.5 nm. This laser was based on diffusion bonded monolith crystal (diameter 3 mm) which combines in one piece an active laser part (Yb:YAG crystal, 10 at.% Yb/Y, 3 mm long) and saturable absorber (V:YAG crystal, 2 mm long, initial transmission 86 % @ 1031 nm). The microchip resonator consisted of dielectric mirrors directly deposited on the monolith surfaces (pump mirror HT @ 968 nm and HR @ 1031 nm on Yb:YAG part, output coupler with reflection 55 % @ 1031 nm on the V:YAG part). For longitudinal CW pumping of Yb:YAG part, a fibre coupled (core diameter 100 μm, NA = 0.22, emission @ 968 nm) laser diode was used. The laser threshold was 3.8W. The laser slope efficiency for output mean in respect to incident pumping was 16 %. The linearly polarized generated transversal intensity beam profile was close to the fundamental Gaussian mode. The generated pulse length, stable and mostly independent on pumping power, was equal to 1.3 ns (FWHM). The single pulse energy was increasing with the pumping power and for the maximum pumping 9.7W it was 78 μJ which corresponds to the pulse peak-power 56 kW. The maximum Yb:YAG/V:YAG microchip laser mean output power of 1W was reached without observable thermal roll-over. The corresponding Q-switched pulses repetition rate was 13.1 kHz.
Management of guided and unguided code generator customizations by using a symbol table (2015)

An essential part of model-driven development to systematically generate concrete source code from abstract input models are code generators. Regardless of their importance, abstract input models are not always suited to describe the output in a concise and precise way. Hence, customizations and adaptations of the code generator and the generated products are needed. Existing approaches mainly regard the code generation process as their primary concern and require the set up of an additional infrastructure in order to manage the customizations and adaptations. Thus, the goal of this paper is to propose an extension for template-based code generators to enable customizations and adaptations within a code generator that also respects referential integrity and reuses existing data structures for efficient management. First, we present a classification of common code generator customization and adaptation approaches (guided and unguided approaches) to identify the main concepts and elements of the approaches. Then, using the derived information relevant to manage guided and unguided approaches, we reuse the existing data structure (symbol table) to manage the customizations and adaptations. We achieve this by associating all relevant information directly with a template. This approach enables dynamic management of customizations and adaptations at run-time of the code generator and allow for statically checking before code generation. Our main contribution is an approach to combine guided and unguided customization approaches with a symbol table for efficient management.
Single-photon detector for long-distance fiber-optic quantum key distribution (2002)

We have investigated the performance of an InGaAs/InP avalanche photodiode for photon counting at 1550 nm in the temperature range of thermoelectric cooling. A quantum efficiency of 13.7% was obtained at -55 degrees C , while the dark-count probability per gate (?1 ns) was kept as small as 2.4x10(-5) . The developed single-photon detector would yield a 104.4-km fiber-optic quantum key distribution in the ideal condition.
Biochemical Decomposition of the Herbicide N-(3,4-Dichlorophenyl)-2-Methylpentanamide and Related Compounds (1969)

Organisms capable of decomposing N-(3,4-dichlorophenyl)-2-methylpentanamide (Karsil) were isolated, identified, and tested for their ability to hydrolyze this herbicide. Primary products of Karsil decomposition by cells and cell-free extracts of a Penicillium sp. were identified as 2-methyl-valeric acid and 3,4-dichloroaniline. The Karsil acylamidase (EC 3.5.1.a aryl acylamine amidohydrolase) was an induced enzyme. It was partially purified and tested for its ability to hydrolyze 25 related compounds. Some relations between the structures of these compounds and their susceptibility to enzymatic hydrolysis were discerned.
The CLIPMERGE PGx Program: Clinical Implementation of Personalized Medicine Through Electronic Health Records and Genomics–Pharmacogenomics (2013)

The exponential rise in genomics research over the past decade has yielded a growing number of sequence variants associated with medication response that may have clinical utility. Despite existing barriers, attention is turning to strategies that integrate these data into clinical care. The CLIPMERGE PGx Program is establishing a best-practices infrastructure for the implementation of genome-informed prescribing using a biobank-derived clinical cohort, preemptive genetic testing, and real-time clinical decision support deployed through the electronic health record. Clinical Pharmacology & Therapeutics (2013); 94 2, 214–217. doi:10.1038/clpt.2013.72
Aging-aware Adaptive Voltage Scaling in 22nm high-K/metal-gate tri-gate CMOS (2015)

Aging-aware Adaptive Voltage Scaling (AVS) can eliminate conventional flat voltage guard band typically added to intrinsic chip V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">CC</sub> to account for transistor aging, therefore reducing power consumption throughout the lifetime of the chip. Aging-aware AVS applied to a Tunable Replica Circuit (TRC) built in a 22nm test chip demonstrates a measured power reduction of a maximum of ~7% at beginning of life and a minimum of ~2% at end of life.
Percutaneous interstitial laser hyperthermia in clinical use. (1994)

Twelve patients were treated with laser-induced hyperthermia. Eight had liver metastases from breast cancer or colorectal cancer, and four were treated for a primary tumour, two in the liver, one in the biliary tract and one in the pancreas. The mean diameter of the metastases was 2.5 cm and of the primary tumours 4 cm. One patient was given ethanol injections before the treatment, and seven were treated with chemotherapy before and two after the treatment. At the time of writing this report, all the patients are still alive. The follow-up times vary from six months to five years. Treatment was technically possible in all cases. The smallest metastasis disappeared totally and, with the exception of a few larger tumours, they were reduced in size. There were no serious complications. The patients were treated percutaneously under ultrasonographic imaging in real time. Only minor side effects were seen, and the method is safe. Technically, laserthermia is easy to perform. A skillful radiologist is needed, and the presence of an anaesthetist makes it possible to safely treat tumours that can be reached only when respiration is controlled mechanically. Controlled, randomized studies are now needed to evaluate the method in comparison with other palliative treatment modalities.
Preparation of [5 + 6]‐, [6 + 6]‐, and [6 + 7]‐Bicyclic Guanidines from <i>C,C</i>'‐Bis(iminophosphoranes) (1994)

Abstract A one‐pot synthesis of [5 + 6]‐, [6 + 6]‐, and [6 + 7]‐rigid bicyclic guanidines ( 6 , 8 , 19 , 21 , 23 ) based on a bis(iminophosphorane)‐mediated annulation strategy is reported. The crystal and molecular structure of the parent [5 + 6]‐bicyclic guanidine 8 has been established by X‐ray diffraction. The crystallographically independent molecule forms dimers through a centre of symmetry by N–H–N hydrogen bonds. The molecule, and therefore the dimer, is statistically disordered in a 65/35 ratio. A statistical study of N–H–N hydrogen bonds of this kind of dimers has been carried out by using the Cambridge Structural Database.
Studies on Protopectinase-C Mode of Action: Analysis of the Chemical Structure of the Specific Substrate in Sugar Beet Protopectin and Characterization of the Enzyme Activity (1993)

Journal Article Studies on Protopectinase-C Mode of Action: Analysis of the Chemical Structure of the Specific Substrate in Sugar Beet Protopectin and Characterization of the Enzyme Activity Get access Tatsuji Sakamoto, Tatsuji Sakamoto Department of Agricultural Chemistry, College of Agriculture, University of Osaka Prefecture, 1–1 Gakuen-cho, Sakai, Osaka 593, Japan Search for other works by this author on: Oxford Academic Google Scholar Junji Yoshinaga, Junji Yoshinaga Department of Agricultural Chemistry, College of Agriculture, University of Osaka Prefecture, 1–1 Gakuen-cho, Sakai, Osaka 593, JapanSawai Pharmaceutical Co., Ltd., 4–25 Akagawa 1-chome, Osaka 535, Japan Search for other works by this author on: Oxford Academic Google Scholar Takeshi Shogaki, Takeshi Shogaki Department of Agricultural Chemistry, College of Agriculture, University of Osaka Prefecture, 1–1 Gakuen-cho, Sakai, Osaka 593, JapanSawai Pharmaceutical Co., Ltd., 4–25 Akagawa 1-chome, Osaka 535, Japan Search for other works by this author on: Oxford Academic Google Scholar Takuo Sakal Takuo Sakal Department of Agricultural Chemistry, College of Agriculture, University of Osaka Prefecture, 1–1 Gakuen-cho, Sakai, Osaka 593, Japan To whom correspondence should be addressed. Search for other works by this author on: Oxford Academic Google Scholar Bioscience, Biotechnology, and Biochemistry, Volume 57, Issue 11, 1 January 1993, Pages 1832–1837, https://doi.org/10.1271/bbb.57.1832 Published: 01 January 1993 Article history Published: 01 January 1993 Received: 19 March 1993
A common phosphotyrosine signature for the Bcr-Abl kinase (2006)

The Bcr-Abl fusion kinase drives oncogenesis in chronic myeloid leukemia (CML). CML patients are currently treated with the Abl tyrosine kinase inhibitor imatinib, which is effective in early stages of the disease. However, resistance to imatinib arises in later disease stages primarily because of a Bcr-Abl mutation. To gain deeper insight into Bcr-Abl signaling pathways, we generated phosphotyrosine profiles for 6 cell lines that represent 3 Bcr-Abl fusion types by using immunoaffinity purification of tyrosine phosphopeptides followed by tandem mass spectrometry. We identified 188 nonredundant tyrosine-phosphorylated sites, 77 of which are novel. By comparing the profiles, we found a number of phosphotyrosine sites common to the 6 cell lines regardless of cellular background and fusion type, several of which are decreased by imatinib treatment. Comparison of this Bcr-Abl signature with the profile of cells expressing an alternative imatinib-sensitive fusion kinase, FIP1L1-PDGFRalpha, revealed that these kinases signal through different pathways. This phosphoproteomic study of the Bcr-Abl fusion kinase highlights novel disease markers and potential drug-responsive biomarkers and adds novel insight into the oncogenic signals driven by the Bcr-Abl kinase.