gebhart/patrepeval huggingface dataset:
DrawerPipe: A Reconfigurable Pipeline for Network Processing on FPGA-Based SmartNIC (2019)

In the public cloud, FPGA-based SmartNICs are widely deployed to accelerate network functions (NFs) for datacenter operators. We argue that with the trend of network as a service (NaaS) in the cloud is also meaningful to accelerate tenant NFs to meet performance requirements. However, in pursuit of high performance, existing work such as AccelNet is carefully designed to accelerate specific NFs for datacenter providers, which sacrifices the flexibility of rapidly deploying new NFs. For most tenants with limited hardware design ability, it is time-consuming to develop NFs from scratch due to the lack of a rapidly reconfigurable framework. In this paper, we present a reconfigurable network processing pipeline, i.e., DrawerPipe, which abstracts packet processing into multiple “drawers” connected by the same interface. NF developers can easily share existing modules with other NFs and simply load core application logic in the appropriate “drawer” to implement new NFs. Furthermore, we propose a programmable module indexing mechanism, namely PMI, which can connect “drawers” in any logical order, to perform distinct NFs for different tenants or flows. Finally, we implemented several highly reusable modules for low-level packet processing, and extended four example NFs (firewall, stateful firewall, load balancer, IDS) based on DrawerPipe. Our evaluation shows that DrawerPipe can easily offload customized packet processing to FPGA with high performance up to 100 Mpps and ultra-low latency (<10 µs). Moreover, DrawerPipe enables modular development of NFs, which is suitable for rapid deployment of NFs. Compared with individual NF development, DrawerPipe reduces the line of code (LoC) of the four NFs above by 68%.
Autonomic Buffer Pool Configuration in PostgreSQL (2006)

As database management systems (DBMSs) continue to expand into new application areas, the complexity of the systems and the diversity of database workloads are increasing. Managing the performance of DBMSs via manual adjustment of resource allocations in this new environment has become impractical. Autonomic DBMSs shift the responsibility for performance management onto the systems themselves. This paper serves as a proof of concept, illustrating how autonomic principles can be applied to a DBMS to provide automatic sizing of buffer pools, a key resource in a DBMS. We describe an implementation of our autonomic system in PostgreSQL, an open source database management system, and provide a set of experiments that verify our approach.
Molecular Recognition: Schiff Base as Molecular Tweezers (1999)

Abstract The self-assembling via hydrogen bonding can be the important basis of the main concept in molecular recognition. We have designed and modified the organic schiff base, N,N′-bis(o-hydroxybenzylidene)diethylenetriamine and its halo- (Cl- or Br-) derivatives as artificial receptors that exhibit the strong binding characteristics to barbituric acid as a guest. 1H-NMR spectroscopic titration has been performed to characterize the noncovalent intermolecular interaction between the schiff base or its halo-derivatives and a barbituric acid molecule.
Virtual Screening for Binding of Phenylalanine Analogues to Phenylalanyl-tRNA Synthetase (2002)

Although incorporation of nonnatural amino acids provides a powerful means of controlling protein structure and function, experimental investigations of amino acid analogues for utilization by the protein biosynthetic machinery can be costly and time-consuming. In this paper, we describe a computational protocol (HierDock) for predicting the relative energies of binding of phenylalanine analogues to phenylalanyl-tRNA synthetase (PheRS). Starting with the crystal structure of Thermus thermophilus PheRS without bound ligand, HierDock predicts the binding site of phenylalanine (Phe) within 1.1 A of that revealed by the crystal structure of PheRS cocrystallized with Phe. The calculated binding energies of Phe analogues in PheRS, using HierDock, correlate well with the translational activities of the same analogues in Escherichia coli. HierDock identifies p-fluorophenylalanine and 3-thienylalanine as especially good substrates for PheRS, in agreement with experiment. These results suggest that the HierDock protocol may be useful for virtual screening of amino acid analogues prior to experiment.
High-Q and CMOS compatible single crystal silicon cantilever with separated on-chip piezoelectric actuator for ultra-sensitive mass detection (2008)

A CMOS compatible single-crystal silicon cantilever with on-chip piezoelectric PZT actuator was developed for ultra-sensitive mass detection. Excellent Q-factor of 1113, which is several times higher than latest reported Q-factor of integrated micro cantilevers, was sucessfully achieved by seperating the piezoelectric actuator from the resonant structure to reduce intrinsic energy dissipation in PZT film. A piezoresistive Wheatstone-bridge gauge was integrated to detect the resonant frequency of the cantilever for better impedence matching with electric circuits. The proposed structure exhibits potential applications in parallel sensor system or networked sensor technology with sub-femtogram level resolution.
The Glucose Revolution: The Authoritative Guide to the Glycemic Index--the Groundbreaking Medical Discovery (1999)

Rev. ed. of: The G.I. factor / Jennie Brand Miller ... [et al.]. Rydalmere, N.S.W. : Hodder Headline, 1998
New agents that stimulate erythropoiesis (2006)

Recombinant human erythropoietin (rhEpo) has proven to be remarkably safe and effective for treatment of anemias, primarily those secondary to renal disease and malignancy. Despite the worldwide use of rhEpo, concerns about its cost, the need for frequent parenteral administration, and the development of anti-Epo antibodies have prompted development of improved agents to stimulate erythropoiesis. Three strategies appear to be particularly promising. The half-life of Epo in the circulation can be prolonged by the addition of N-linked carbohydrate groups, by formation of adducts with polyethylene glycol, and by preparation of Epo multimers. Second, mimetic peptides can effectively trigger signal transduction at the Epo receptor, thereby boosting red-cell production. Finally, the hypoxia inducible transcription factor (HIF) can be pharmacologically induced by oral agents, resulting in enhanced expression not only of endogenous Epo but also of other genes important in the regulation of erythropoiesis.
Evaluating occupational hazards using information known only to employers: a comparative study. (1983)

A comparative study was conducted to assess empirically the suspected bias associated with occupational health studies based only on information obtainable from employers' records. Standardised mortality ratios were extracted from five occupational cohorts for which extensive follow up had been conducted and were compared with proportional mortality ratios based on deaths known (KTE) and unknown (UTE) to the employer, and on total deaths. For the five cohorts examined the suspected bias for the cause of death categories all cancer, respiratory cancer, heart disease, and accidents was generally found to be minimal unless the number of UTE deaths was in excess of 75%. Furthermore, a strong inverse relationship was observed between the percentage of UTE deaths and the level of agreement between proportional mortality ratios based on KTE deaths and total deaths. In partial support of these findings it was also observed that workers who left the industry in three of the five cohorts subsequently experienced similar overall mortality compared with those who continued employment. These findings should serve as a rough indication of the potential value of estimating disease risks from KTE deaths and serve as a guide for other investigators using limited data.
Inheritable and Precise Large Genomic Deletions of Non-Coding RNA Genes in Zebrafish Using TALENs (2013)

Transcription activator-like effector nucleases (TALENs) have so far been applied to disrupt protein-coding genes which constitute only 2-3% of the genome in animals. The majority (70-90%) of the animal genome is actually transcribed as non-coding RNAs (ncRNAs), yet the lack of efficient tools to knockout ncRNA genes hinders studies on their in vivo functions. Here we have developed novel strategies using TALENs to achieve precise and inheritable large genomic deletions and knockout of ncRNA genes in zebrafish. We have demonstrated that individual miRNA genes could be disrupted using one pair of TALENs, whereas large microRNA (miRNA) gene clusters and long non-coding RNA (lncRNA) genes could be precisely deleted using two pairs of TALENs. We have generated large genomic deletions of two miRNA clusters (the 1.2 kb miR-17-92 cluster and the 79.8 kb miR-430 cluster) and one long non-coding RNA (lncRNA) gene (the 9.0 kb malat1), and the deletions are transmitted through the germline. Taken together, our results establish TALENs as a robust tool to engineer large genomic deletions and knockout of ncRNA genes, thus opening up new avenues in the application of TALENs to study the genome in vivo.
Amino acid change associated with the major polymorphic Hinc II site of Oriental and Caucasian mitochondrial DNAs. (1983)

The mitochondrial DNAs (mtDNAs) from 116 Oriental and Caucasian blood samples were analyzed for their Hinc II restriction endonuclease cleavage patterns using Southern analysis and 32P human mtDNA probes. Seven distinct patterns were found, all of which could be interrelated by single nucleotide changes. The predominant pattern (mtHinc II-2) was found in 97% of the Caucasians and 73% of the Orientals. This mtDNA morph had one more Hinc II site than did the second most common morph (mtHinc II-1), which was found only in 20% of the Orientals. Three additional patterns were in a single Oriental sample, a fourth in a single Caucasian sample, and a fifth in one member of each population. The polymorphic site that differentiated mtHinc II-1 and mtHinc II-2 was cloned and sequenced. A single nucleotide change was found that created an Hinc II site and changed the amino acid sequence of the URF5 gene. Comparison of these sequences with those of other primates [15] revealed that the Asian mtHinc II-1 and mtHinc II-4 mtDNAs were identical in this region with those of chimpanzees and orangutans. These results suggest that the Asian mtHinc II-1 mtDNA may have been ancestral to other human mtDNAs.
Steroid-sparing properties of sargramostim in patients with corticosteroid-dependent Crohn’s disease: a randomised, double-blind, placebo-controlled, phase 2 study (2009)

Sargramostim was more effective than placebo for inducing corticosteroid-free remission in patients with Crohn's disease with corticosteroid dependence. Sargramostim may provide significant benefit in this population if these findings are confirmed.
A 10-GHz 8-b multiplexer/demultiplexer chip set for the SONET STS-192 system (1991)

An ultrahigh-speed 8-b multiplexer (MUX) and demultiplexer (DMUX) chip set has been developed for the synchronous optical network (SONET) next-generation optical-fiber communication systems, which will require data bit rates of about 10 Gb/s. These ICs were designed using three novel concepts: a tree-type architecture giving reliable operation, a dynamic divider with a wide operating range, and a 50- Omega on-chip transmission line with high-speed pulse propagation. They were fabricated using a 0.5- mu m WN/sub x/-gate GaAs MESFET process. The DMUX and MUX operated at up to 10.4 and 11.4 GHz, respectively, both with an adequate phase margin of more than 230 degrees .< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Design and implementation of time division-fourth generation (TD-4G) gigabit speed wireless communication system (2010)

When developing gigabit speed communication systems, a lot of design and implementation challenges emerge. And prototype is important to assess the overall system performance and complexity trade-offs under real-world conditions. In this contribution, prototype design and implementation of a time di
Real-Time Observation of Temperature Rise and Thermal Breakdown Processes in Organic LEDs Using an IR Imaging and Analysis System (2000)

Organic light-emitting diodes (OLEDs) have enjoyed significant progress in terms of practical applications; however, their lifetimes are often limited by poor thermal stability. These authors have monitored the surface temperature of working OLED devices and identified “hot spots” due to electrical shorting using an infrared imaging and analysis system. Thermal breakdown in the devices is shown to have its origins in the electric-field-induced decomposition of indium tin oxide and electromigration of indium through the organic layer under high electric field.
Carrier storage time of milliseconds at room temperature in self-organized quantum dots (2006)

Thermally activated hole emission from differently charged InAs∕GaAs quantum dots (QDs) was investigated by using deep level transient spectroscopy. In a sample with an additional AlGaAs barrier below the QD layer, a thermal activation energy of 560meV for hole emission from the QD ground states over the AlGaAs barrier is obtained. This large activation energy leads to a hole storage time at room temperature of about 5ms, which is in the order of magnitude of a typical dynamic random access memory (DRAM) refresh time.
Stable expression of a heterogeneous gene introduced via gene targeting into the <i>HPRT</i> locus of human fibrosarcoma cells (2006)

To obtain a cell line that maintains stability of gene expression is important for industrial production of therapeutic proteins from recombinant cells. In this study, we attempted to improve the stability of expression of an exogenous gene by using the gene-targeting method in cultured cells. In our gene-targeting system, the green fluorescent protein (GFP) gene was used as an exogenous reporter gene targeted to the locus of the endogenous hypoxanthine phosphoribosyl transferase (HPRT) gene, which is constitutively expressed. Cell lines selected using markers of the targeting DNA were cultivated for 129 days without any drug selection, and the expression levels of GFP protein and the chromosomal structure of the gfp gene in these cell lines were evaluated. Cell lines in which gfp genes were randomly integrated into the genome showed decreased GFP expression, which resulted from loss of genes or attenuation of transcription. In contrast, cell lines in which the gfp gene was targeted to the hprt locus maintained a stable chromosomal structure and stable expression of the gfp gene, even after prolonged cultivation. These results suggest that constitutively expressed endogenous gene loci may be suitable positions for stable expression of exogenous genes, and that the gene-targeting strategy presented here may be useful for generation of cell lines for industrial protein production.
Screening for Non-Insulin-Dependent Diabetes Mellitus (NIDDM): How Often Should it Be Performed? (1994)

Repeat screening after 30 months has a high response rate, similar rate of detection of glycosuria, and a further yield of 0.44% of newly diagnosed cases of diabetes. A screening programme detecting postprandial glycosuria identifies additional diabetic subjects 30 months after a previous screening programme.
Inhibin and Activin Modulate Human Monocyte Chemotaxis and Human Lymphocyte Interferon-γ Production* (1991)

Inhibin and activin are referred to as gonadal glycoprotein hormones whose function is the control of FSH release from the pituitary gland. However, several observations indicate that inhibin and activin are produced in various organs and serve multiple functions. Because bone marrow and spleen produce inhibin and activin, our aim was to evaluate their possible effect on cell-mediated immune function. For this reason we studied 1) monocyte chemotaxis, 2) lymphocyte interferon-gamma production, 3) phytohemagglutinin-induced lymphocyte proliferation, and 4) nonmajor histocompatibility complex-restricted and lymphokine-activated lymphocyte cytotoxicity. All studies were performed on human peripheral blood cells in the absence or presence of various doses of inhibin, activin, or inhibin plus activin. A significant dose-related increase in monocyte chemotaxis was induced by inhibin. Activin increased the migrational activity of monocytes, but via random, not directed, migration. Inhibin significantly decreased interferon-gamma production, and its effect was reversed by activin. Inhibin and/or activin had no significant effect on either phytohemagglutinin-induced lymphocyte proliferation or lymphocyte cytotoxic capability. The present demonstration that inhibin and activin may affect some immune parameters suggests a possible involvement of these hormones in regulating cell-mediated immune function.
Adherence to immunosuppressants: how can it be improved in adolescent organ transplant recipients? (2010)

Strategies for promoting adherence in adolescent transplant recipients should include developmentally appropriate models and should incorporate health-related education, motivational strategies, and behavioral skills. Interventions should be tailored to meet individual needs, and should be a collaborative effort between the adolescent, family and healthcare providers.
Combined Task and Motion Planning for Mobile Manipulation (2010)

We present a hierarchical planning system and its application to robotic manipulation. The novel features of the system are: 1) it finds high-quality kinematic solutions to task-level problems; 2) it takes advantage of subtask-specific irrelevance information, reusing optimal solutions to state-abstracted subproblems across the search space. We briefly describe how the system handles uncertainty during plan execution, and present results on discrete problems as well as pick-and-place tasks for a mobile robot.
Dual Cholinergic Control of Fast-Spiking Interneurons in the Neostriatum (2002)

GABAergic interneurons appear to play a fundamental role in the functioning of the neostriatum by modulating the spiking of striatal projection neurons with great efficacy. The powerful and strongly divergent output of the GABAergic interneurons neurons suggests that modulation of their activity may be particularly effective at controlling the functioning of the entire neostriatal circuitry. Acetylcholine is one of the main modulators of striatal functioning. The effects of acetylcholine on fast-spiking (FS) GABAergic interneurons were studied with whole-cell recording in an in vitro slice preparation. Acetylcholine exerted two distinct effects on fast-spiking interneurons. Acetylcholine directly depolarized FS interneurons by acting on nondesensitizing soma-dendritic nicotinic receptors. In addition, acetylcholine attenuated the GABAergic inhibition of projection neurons by fast-spiking interneurons through activation of presynaptic muscarinic receptors. It is suggested that the nicotinic excitation of FS interneurons may play an important role in translating the effect of the brief behaviorally contingent cessation of firing of the tonically active cholinergic interneurons to the output neurons of the neostriatum. In contrast, the muscarinic presynaptic inhibitory mechanism may be engaged primarily during longer-lasting elevations of extracellular acetylcholine levels.
Genetically Induced Tumors in the Oncopig Model Invoke an Antitumor Immune Response Dominated by Cytotoxic CD8β+ T Cells and Differentiated γδ T Cells Alongside a Regulatory Response Mediated by FOXP3+ T Cells and Immunoregulatory Molecules (2018)

In recent years, immunotherapy has shown considerable promise in the management of several malignancies. However, the majority of preclinical studies have been conducted in rodents, the results of which often translate poorly to patients given the substantial differences between murine and human immunology. As the porcine immune system is far more analogous to that of humans, pigs may serve as a supplementary preclinical model for future testing of such therapies. We have generated the genetically modified Oncopig with inducible tumor formation resulting from concomitant <i>KRAS<sup>G12D</sup></i> and <i>TP53<sup>R167H</sup></i> mutations under control of an adenoviral vector Cre-recombinase (AdCre). The objective of this study was to characterize the tumor microenvironment in this novel animal model with respect to T-cell responses in particular and to elucidate the potential use of Oncopigs for future preclinical testing of cancer immunotherapies. In this study, we observed pronounced intratumoral T-cell infiltration with a strong CD8β<sup>+</sup> predominance alongside a representation of highly differentiated γδ T cells. The infiltrating CD8β<sup>+</sup> T cells displayed increased expression of the cytotoxic marker perforin when compared with the peripheral T-cell pool. Similarly, there was robust granzyme B staining localizing to the tumors; affirming the presence of cytotoxic immune cells within the tumor. In parallel with this antitumor immune response, the tumors displayed enrichment in FOXP3-expressing T cells and increased gene expression of indoleamine 2,3-dioxygenase 1 (<i>IDO1</i>), cytotoxic T-lymphocyte-associated protein 4 (<i>CTLA4</i>), and programmed death-ligand 1 (<i>PDL1</i>). Finally, we investigated the Oncopig immune system in mediating antitumor immunity. We observed pronounced killing of autologous tumor cells, which demonstrates the propensity of the Oncopig immune system to recognize and mount a cytotoxic response against tumor cells. Together, these findings suggest innate and adaptive recognition of the induced tumors with a concomitant <i>in vivo</i> suppression of T-cell effector functions. Combined, the data support that the Oncopig may serve as a valuable model for future preclinical testing of immunotherapies aimed at reactivating tumor-directed cytotoxicity <i>in vivo</i>.
Le laboratoire au service de la cancérologie (1987)

info:eu-repo/semantics/published
Biocatalysis in Organic Synthesis: The Use of Nitrile- and Amide-hydrolyzing Microorganisms (1997)

This review covers recent examples of synthetic transformation of nitriles and amides by microbial enzyme systems. A variety of substrates and products involving enantiomerically enriched forms of chiral substances are referred to. The stereochemical course of enzyme-catalyzed hydrolysis is briefly commented on. Special emphasis is placed upon the range of functional groups that are acceptable by enzymes and/or survive under the transformation, as well as the advantages as a synthetic tool for conversion under mild conditions.
Photomultiplier Single Photon Counting Efficiency (1973)

An RCA C31000F (8853) photomultiplier with a cathode quantum efficiency of 5.5% (for 633-nm light) was found to have a single photon counting efficiency of only 3.3%. The difference is shown to be due to small pulses well below the single electron peak in the output pulse height spectrum. These pulses are usually below the discriminator threshold level and are not counted. The reason for the small pulses is not understood.