gebhart/patrepeval huggingface dataset:
The canine model of dietary hypersensitivity (2005)

IgE-mediated dietary hypersensitivity affects approximately 1% of the canine population. There are no breed associations and < or =50% of the patients are aged <1 year at presentation. The most common causative allergens are beef, chicken, milk, eggs, maize, wheat and soyabean. Affected dogs generally display cutaneous disease and 10-15% of the patients may have concurrent alimentary involvement. Diagnosis is currently based on dietary restriction followed by provocation. Procedures for the detection of serum allergen-specific IgE and IgG antibodies are widely available, but these tests correlate poorly with clinical presentation and dietary testing. Recent studies have demonstrated the allergen specificity of IgE antibodies by immunoblotting and have described blood lymphocyte proliferative responses to food allergens. In addition to investigations of spontaneously-arising dietary hypersensitivity, it has also proved possible to study this disorder experimentally. Small colonies of dogs sensitive to particular dietary proteins have been used to study clinical and serological responses to allergen challenge. Hypersensitivity has been experimentally induced in dogs of an atopic phenotype by repeated subcutaneous injection of alum-adjuvanted dietary allergen during neonatal life. These models have been used to trial a range of modified protein or hydrolysate diets. The dog provides a unique large-animal model for investigation of the immunopathogenesis of human dietary hypersensitivity. The dog is closely related genetically to man and shares environmental disease triggers with man. Spontaneously arising canine dietary hypersensitivity is a good clinical mimic of the human disease, and ability to therapeutically manipulate this adverse response in the dog might lead to benefits for human patients.
On Man-In-The-Cloud (MITC) attacks: The analytical case of Linux (2017)

Device synchronization is a new technology integrated into the cloud which has seen widespread implementation from major cloud vendors but has not been spared of attacks by MITC attacks directed towards cloud synchronization achieved via a myriad of attack vectors. These target the synchronization token which lacks authenticity validation of the token bearer. We explore MITC in Linux systems by partitioning the cloud into abstract layers and employing a conceptual finite state machine for system security modeling and attack trees for analysis. We further deduce MITC attack properties and contrast them against conventional attacks and thus recommend mitigation techniques.
Comparative Evaluation of Elliptic Curve Cryptography Based Homomorphic Encryption Schemes for a Novel Secure Multiparty Computation (2014)

In this paper, we focus on Elliptic Curve Cryptography based approach for Secure Multiparty Computation (SMC) problem. Widespread proliferation of data and the growth of communication technologies have enabled collaborative computations among parties in distributed scenario. Preserving privacy of data owned by parties is crucial in such scenarios. Classical approach to SMC is to perform computation using Trusted Third Party (TTP). However, in practical scenario, TTPs are hard to achieve and it is imperative to eliminate TTP in SMC. In addition, existing solutions proposed for SMC use classical homomorphic encryption schemes such as RSA and Paillier. Due to the higher cost incurred by such cryptosystems, the resultant SMC protocols are not scalable. We propose Elliptic Curve Cryptography (ECC) based approach for SMC that is scalable in terms of computational and communication cost and avoids TTP. In literature, there do exist various ECC based homomorphic schemes and it is imperative to investigate and analyze these schemes in order to select the suitable for a given application. In this paper, we empirically analyze various ECC based homomorphic encryption schemes based on performance metrics such as computational cost and communication cost. We recommend an efficient algorithm amongst several selected ones, that offers security with lesser overheads and can be applied in any application demanding privacy.
Review: <i>The Historical Society of Southern California TOPICAL INDEX</i>, by Anna Marie Hager, Everett Gordon Hager, Gustave O. Arlt, and W. W. Robinson (1960)

Book Review| March 01 1960 Review: The Historical Society of Southern California TOPICAL INDEX, by Anna Marie Hager, Everett Gordon Hager, Gustave O. Arlt, and W. W. Robinson The Historical Society of Southern California TOPICAL INDEXAnna Marie HagerEverett Gordon HagerGustave O. ArltW. W. Robinson Donald C. Cutter Donald C. Cutter Search for other works by this author on: This Site PubMed Google Scholar The Historical Society of Southern California Quarterly (1960) 42 (1): 95–96. https://doi.org/10.2307/41169434 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Cite Icon Cite Search Site Citation Donald C. Cutter; Review: The Historical Society of Southern California TOPICAL INDEX, by Anna Marie Hager, Everett Gordon Hager, Gustave O. Arlt, and W. W. Robinson. The Historical Society of Southern California Quarterly 1 March 1960; 42 (1): 95–96. doi: https://doi.org/10.2307/41169434 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentSouthern California Quarterly Search This content is only available via PDF. Article PDF first page preview Close Modal You do not currently have access to this content.
Structural basis for bending of organic crystals (2005)

Bending is observed in organic crystals when the packing is anisotropic in such a way that strong and weak interaction patterns occur in nearly perpendicular directions.
Fluoroprofile, a fluorescence‐based assay for rapid and sensitive quantitation of proteins in solution (2005)

The development of a sensitive fluorescence-based assay for the quantitative determination of protein concentration is described. The assay is based on the natural product epicocconone, which produces a large increase in fluorescence quantum yield upon binding to detergent-coated proteins in solution. There is a concomitant shift in the emission maximum from 520 to 605 nm after binding, which results in low background signal allowing a linear dynamic range of 40 ng/mL to 200 microg/mL for most proteins. There is little protein-to-protein variation except for iron-containing proteins and the assay can be used so that it is tolerant of chemicals commonly used in 2-D sample buffers. The assay is more sensitive than standard absorption assays such as the Bradford and Lowry assays, and has a greater dynamic range and sensitivity than other fluorescent assays.
Improved performance of Reed-Solomon decoding with the use of pilot signals for erasure generation (2002)

The performance of a Reed-Solomon (RS) decoder can be improved by allowing errors and erasures (E&E) decoding if each error location is correctly identified, or "flagged", and considered as an erasure. However, in order to be effective, it is imperative that the erasure flagging is accurate. We propose the use of pilot signals in a new method for flagging erasures. A Bayesian method for optimum character erasure flagging is derived which uses both the received data signals and the channel estimates provided by pilot signals, and a simpler method is presented which flags erasures on a modulation symbol basis. Our simulation results demonstrate that combining pilot signals with E&E decoding results in significant transmit power savings.
Relationship between the tonB locus and iron transport in Escherichia coli (1975)

When a strain (arcB-) of Escherichia coli, unable to synthesize the iron transport compound enterochelin, was transduced to tonB-, it became resistant to phage phi80 and simultaneously lost the growth response to enterochelin and the ability to transport its iron complex. However, enterochelin precursors (shikimate and 2,3-dihydroxybenzoate) still supported growth, via the synthesis of enterochelin. Dihydroxybenzoate was a better growth factor at a low concentration than it was at higher levels. The evidence suggests that tonB- strains lack an outer membrane component necessary both for the uptake of ferric-enterochelin and for the adsorption of phage phi80. Thus, although ferric-enterochelin cannot penetrate the cell surface from outside, the complex that is formed within the envelope is transported normally into the cell. The aroB-, tonB- mutant also lacked growth reponses to citrate and various hydroxamate siderochromes, which supported growth in the tonB+ parent strain via inducible transport systems for their ferric complexes. The aroB-, tonB- mutant was unable to transport iron in the presence of citrate, but the low-affinity uptake of uncomplexed iron and the transport of amino acids and phosphate were unimpaired. The tonB locus, thus, affects all the known active transport systems for iron, possibly indicating that they share some common outer membrane component.
Faraday rotation in magnetic γ-Fe2O3/SiO2 nanocomposites (1997)

Faraday rotation spectrum has been measured at room temperature in a magnetic nanocomposite of γ-Fe2O3/SiO2. The material consists of isolated γ-Fe2O3 nanoparticles dispersed in a silica matrix, and it was prepared through a sol-gel method. The composite contains 18% of γ-Fe2O3 in weight with an average particle size of 20 nm. It has a coercitivity of 30 Oe and an MS of 6 emu/g. The specific Faraday rotation spectrum exhibits a narrow peak centered around 765 nm, reaching a value of 110°/cm and an absorption coefficient of 64 cm−1. Faraday rotation versus applied field has also been measured, and a cycle similar to the one described by the magnetization has been found.
Computerized Data Acquisition and Analysis for the Life Sciences (2001)

Computerized data acquisition systems are often the principle method of recording experimental results. This book takes the reader step-by-step through the process of data acquisition and analysis, explaining how to set up the systems and then obtain useful information from the data recorded. In an easy-to-read style, it guides researchers through the basics of data acquisition systems, explains the important underlying concepts, and gives numerous examples of how to analyze the recorded information. While aimed at researchers in the life sciences, the topics covered are general and will be valuable to anyone interested in learning to use data acquisition systems. The principles can be applied to the collection of data from respiratory apparatus to behavioral science experiments, and a host of other situations. Many illustrations and worked examples accompany the text, and the mathematics are kept simple. This book is an invaluable tool for the non-engineer who is collecting and analyzing experimental data using data acquisition systems.
Pharmacokinetics of Bupropion and its Metabolites in Cigarette Smokers versus Nonsmokers (1997)

Bupropion is an antidepressant agent that is also effective as an aid to quit cigarette smoking. A single 150-mg tablet of sustained-release bupropion hydrochloride was administered to two groups of volunteers, cigarette smokers and nonsmokers, who were matched for race, gender, body frame, age, and weight. Pharmacokinetic parameters were calculated for bupropion, and three major metabolites (hydroxybupropion and the aminoalcohol isomers, threohydrobupropion and erythrohydrobupropion, expressed as a composite total). Mean (+/-SD) values of area under the concentration-time curve from time 0 extrapolated to infinity (AUC0-infinity), maximum concentration (Cmax), time to reach Cmax (tmax), and half-life (t1/2) of bupropion in smokers and nonsmokers, respectively, were 1,164 +/- 220 ng.hr/mL and 1,161 +/- 292 ng.hr/mL; 144 +/- 28 ng/mL and 143 +/- 39 ng/mL; 3.00 +/- 0.50 hours and 2.88 +/- 0.49 hours; and 19 +/- 5 hours and 18 +/- 3 hours. No clinically significant differences between smokers and nonsmokers or between male and female volunteers were observed for the pharmacokinetics of bupropion or its metabolites. The absence of pharmacokinetic differences indicates that dosage adjustments are not necessary when bupropion is prescribed to male and female cigarette smokers.
Coherent optical detection through two-wave mixing in photorefractive materials (1988)

Photorefractively induced index-of-refraction phase gratings are shown to combine coherently the optical fields of a strong pump and a suitably amplitude- or phase-modulated signal beam in such a way that an apparent amplification of the modulating waveform appears as intensity modulation of the transmitted signal and pump beam intensities. The source of the signal gain is shown to be the square-law (intensity) detection of the coherently combined pump and modulated signal beams, just as in coherent optical communication systems in which a strong local-oscillator field is coherently added with a weak optical signal field by a beam splitter.
Digital signal processing for doppler radar signals (2005)

In a pulsed-doppler radar system the return signal is naturally viewed as a sequence of samples of one or more complex sinusoids plus noise. We have studied several digital processing techniques for estimating a short-time spectral representation of such signals as well as digital techniques for estimating the frequency of a single dominant spectral component. Techniques considered include: (1) Discrete short-time Fourier analysis followed by peak-picking and median smoothing to remove errors. (2) Short-time maximum entropy spectrum estimation incorporating adaptive noise suppression. (3) A new recursive algorithm based on recursive computation of the short-time auto-correlation function. The relative merits of each technique are discussed and examples of performance are given.
Applied anatomy and physiology of the feline lower urinary tract. (1996)

Paired ureters, urinary bladder, and urethra constitute the lower urinary tract. Oblique passage of ureters through the bladder wall results in compression of the distal ureter to preclude urine reflux. Ureters are anchored by longitudinal ureteral musculature that outlines the bladder trigone and extends into dorsal submucosa of the urethra as urethral crest. The urinary bladder can be divided into apex, body, and neck. The male urethra has penile and pelvic components, the latter is divisible into preprostatic, prostatic, and postprostatic regions. The muscle coat of the bladder-urethra forms three functional entities in craniocaudal series. These are the detrusor muscle (to effect voiding), internal urethral sphincter (smooth muscle for generating tonic resistance), and external urethral sphincter (striated urethralis m. for phasic and voluntary continence). The vesical neck is a transition region. It is part of the internal urethral sphincter by virtue of its histology and innervation, but it contains detrusor fascicles that pull it open during micturition. Viscous accommodation plus sympathetic reflex inhibition of the vesical wall allows the urinary bladder to greatly expand in volume with minimal increase of intravesical pressure, within limits. At low volumes continence can be maintained by passive resistive elements of the urethral outlet. As volume increases, sympathetic reflex activity is necessary for continence. The striated external urethral sphincter is reflexly contracted to counter abrupt elevations of intravesical pressure and to maintain continence voluntarily. The pelvic plexus conveys sympathetic and parasympathetic innervation to the urinary tract. The pudendal nerve supplies the urethra and urethralis muscle. Ureters are largely independent of innervation. Internal and external urethral sphincters are activated by spinal reflexes, sympathetic and somatic reflexes, respectively. Normal micturition (sustained detrusor contraction and sphincter inhibition) is a brainstem-driven reflex, involving a spino-bulbo-spinal pathway and a pontine micturition center that switches from urine storage to micturition. All of the reflexes depend on neural activity in tension mechanoreceptors of the bladder wall and sacral afferent fibers.
Postnatal development of the endbulb of Held in congenitally deaf cats (2010)

The endbulbs of Held are formed by the ascending branches of myelinated auditory nerve fibers and represent one of the largest synaptic endings in the brain. Normally, these endings are highly branched and each can form up to 1000 dome-shaped synapses. The deaf white cat is a model of congenital deafness involving a type of cochleosaccular degeneration that mimics the Scheibe deformity in humans. Endbulbs of mature deaf white cats exhibit reduced branching, hypertrophy of postsynaptic densities (PSDs), and changes in synaptic vesicle density. Because cats are essentially deaf at birth, we sought to determine if the progression of brain abnormalities was linked in time to the failure of normal hearing development. The rationale was that the lack of sound-evoked activity would trigger pathologic change in deaf kittens. The cochleae of deaf cats did not exhibit abnormal morphology at birth. After the first postnatal week, however, the presence of a collapsed scala media signaled the difference between deaf and hearing cats. By working backwards in age, endbulbs of deaf cats expressed flattened and elongated PSDs and increased synaptic vesicle density as compared to normal endbulbs. These differences are present at birth in some white kittens, presaging deafness despite their normal cochlear histology. We speculate that hearing pathology is signaled by a perinatal loss of spontaneous bursting activity in auditory nerve fibers or perhaps by some factor released by hair cell synapses before obliteration of the organ of Corti.
From hypertension to heart failure (2000)

Hypertension is a risk factor for the development of heart failure (HF) although the two disease processes have previously been considered clinically and mechanistically distinct. It is now clear that both are progressive cardiovascular structural processes that act in cardiac and vascular remodelling as contributors to morbid events. Blood pressure lowering can no longer be the sole goal of therapy for hypertension and improved myocardial contractility can no longer be the focus of therapy for HF. In both diseases a slowing of the progressive structural abnormality should be the therapeutic target. Furthermore, similar drug therapies (angiotension-converting enzyme inhibitors, beta-blockers, diuretics, angiotensin receptor blockers, calcium antagonists) are used in both conditions and have shown variable effectiveness in slowing the structural processes in the heart and vasculature. Newer methods of evaluating structural alterations in the arteries and heart should facilitate the development and utilization of better targeted therapy.
PBTI response to interfacial layer thickness variation in Hf-based HKMG nFETs (2010)

The impact of SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> interfacial layer (IL) thickness on the Positive Bias Temperature Instability (PBTI) is investigated for nMOSFETs with an IL/High-K/metal/poly-Si gate stack architecture. Results from extensive PBTI measurements using three different measurement methodologies consistently demonstrate that thickening the IL results in threshold voltage (V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</sub> ) instability reduction and thus significantly enhances PBTI device lifetime. The voltage acceleration is found to increase with thicker IL, while the PBTI fractional recovery is independent of the IL thickness, providing new insights into the PBTI buildup and recovery mechanisms.
Automated Alignment and Splicing for Multicore Fibers (2013)

A novel method for aligning multi-core fibers (MCF) provides a systematic approach for MCF splicing in the lab, in cable factories, and in the field. This method also provides possibility of loss estimation for side-cores using IPA method and central core with WSI images.
Physician assistants as physician extenders in the pediatric intensive care unit setting???A 5-year experience (2005)

Physician assistants play a complementary role as physician extenders in the pediatric intensive care unit, enabling compliance with New York state and Accreditation Council for Graduate Medical Education resident work hour regulations. Physician assistants perform similar tasks and activities as the pediatric intensive care unit residents and integrate well with them in enhancing bedside patient care. Over time, physician assistants provide additional direction to the residents by virtue of their familiarity with unit-specific policies and procedures and repetitive pediatric intensive care unit practice patterns. As multifunctional members of the health care team, they support nursing and respiratory therapy functions and improve the day-to-day functioning of the unit. The physician assistant serves as a key member of the pediatric intensive care unit transport team. Limitations observed include high job turnover rates among the physician assistants and confusion between their role as shift workers or professional employees.
The effect of cochleostomy and intracochlear infusion on auditory brain stem response threshold in the guinea pig. (1999)

Cochleostomy and intracochlear infusion result in auditory insult limited largely to the region of surgical trauma. Demonstration of hearing preservation after surgical breach of the cochlea should encourage further development of potential diagnostic and therapeutic intervention into the inner ear.
Networks for digital-to-analogue shaft-position transducers (1954)

DIGITAL computers have been used extensively in the solution of mathematical problems requiring both speed and accuracy in their computation. More recently, digital computers are being employed to control analogue equipment. The control of machine tools is one example of this application.1
Inflammation and cancer, the mastocytoma P815 tumor model revisited: Triggering of macrophage activation <i>in vivo</i> with pro‐tumorigenic consequences (2002)

Abstract Subcutaneous in vivo injections of cells of the mastocytoma line P815 in syngenic DBA/2 mice induce locally fast growing solid tumors. These have been used extensively as a cancer model to analyze and manipulate the relationship between tumor cells and host's immune defenses. We report that progression of P815 tumors in vivo was accompanied by a burst (Days 5–7) of local inflammatory cells recruitment and angiogenesis observed histologically, corroborated in vivo by MRI with gadolinium, overtranscription of macrophage activation marker genes, secretion of TNF‐α by regional lymph node cells and concomitant systemic inflammation. No substantial overtranscriptions of either VEGF or IL‐10 or TGF‐β genes were observed. Induction of COX‐2 gene was a late event. To establish a possible relationship between the tumor‐induced local, regional and systemic increase of pro‐inflammatory mediators and progression of tumors in vivo , we carried out experiments deliberately modulating the inflammatory status of the recipient animals. Pretreatment of recipient animals by i.p. injection of thioglycolate accelerated P815 tumor growth. At the opposite, treatment of mice with either a COX‐1 + COX‐2 inhibitor (aspirin, 1 mg/day/mouse) or a specific COX‐2 inhibitor (celecoxib, 0.13 mg/day/mouse) for 2 weeks after injection of tumor cells, significantly reduced the size and growth rate of tumors compared to control mice. Experiments carried out in vitro indicated that peritoneal macrophages from untreated animals were strongly activated by live P815 cells and by P815 membrane preparations. The tumor‐induced inflammatory reaction could establish a local micro environment favoring tumor progression. The P815 tumor model might be helpful to recognize important factors controlling host/tumor relationship. © 2002 Wiley‐Liss, Inc.