gebhart/patrepeval huggingface dataset:
Scheduling in Computer and Manufacturing Systems. (1993)

A theoretical and application-oriented analysis of deterministic scheduling problems arising in computer and manufacturing environments. The important classical results are surveyed with particular attention paid to single-processor scheduling, along with general models such as resource-constrained scheduling, flexible flow shops, dynamic job shops, and special flexible manufacturing systems. Polynomial and exponential-time optimization algorithms as well as approximation and heuristic ones are presented using a Pascal-like notation, before being discussed in the light of particular problems. Basic concepts from scheduling theory and related fields are described to assist less advanced readers.
The metabolic “switch” AMPK regulates cardiac heparin-releasable lipoprotein lipase (2004)

The "fuel gauge" AMP-activated protein kinase (AMPK) facilitates ATP production to meet energy demands during metabolic stress. Given the importance of lipoprotein lipase (LPL) in providing hearts with fatty acids (FA), the preferred substrate consumed by the heart, the objective of the present study was to investigate whether activation of AMPK influences LPL at its functionally relevant location, the coronary lumen. Hearts from overnight-fasted rats were first perfused with heparin to release LPL, and homogenates from these hearts were then used to measure total and phospho-AMPK-alpha by Western blotting. Manipulation of AMPK activity [with drugs like adenine 9-beta-D-arabinofuranoside (Ara-A) and insulin (that inhibit) or perhexiline and oligomycin (that stimulate)] and its influence on LPL was also determined. Fasting augmented the activity of both AMPK and luminal LPL on immediate removal of hearts, effects that still remained even after in vitro perfusion of hearts for 1 h. Inhibition of AMPK in fasted hearts using an inhibitor like Ara-A or through provision of insulin markedly lowered the enhanced luminal LPL activity. In contrast, AMPK activators, like perhexiline and oligomycin, produced a significant elevation in heparin-releasable LPL activity. Thus, with fasting or drugs that influence AMPK, a strong correlation between this metabolic switch and cardiac LPL activity was established. Our data suggest that, in addition to its direct role in promoting FA oxidation, AMPK-mediated recruitment of LPL to the coronary lumen could represent an immediate compensatory response by the heart to guarantee FA supply.
A synthetic gene coding for the green fluorescent protein (GFP) is a versatile reporter in Chlamydomonas reinhardtii<sup>†</sup> (1999)

The use of Chlamydomonas reinhardtii as a model system has been hindered by difficulties encountered in expressing foreign genes. We have synthesised a gene encoding green fluorescent protein (GFP) adapted to the codon usage of C. reinhardtii (cgfp). After verifying the gene was functional in Escherichia coli, the cgfp was fused in frame to the phleomycin resistance gene ble from Streptoalloteichus hindustanus and expressed in C. reinhardtii under control of the rbcS2 promoter and intron sequences. The GFP-fluorescence was seen only in the nucleus demonstrating the nuclear accumulation of the Ble-GFP fusion protein. The cgfp was also fused to the chlamyopsin gene, cop, and expressed in C. reinhardtii under control of the cop promoter. The eyespot became fluorescent indicating that the opsin-GFP fusion protein was correctly directed into the eyespot along with the endogenous unmodified opsin. We conclude that cgfp provides a useful tool to visualize protein synthesis and localisation in vivo in C. reinhardtii and possibly in related green algal species.
246. The “hydrosulphides” of carvone and 1-4-isopropyl-Δ<sup>2</sup>-cyclohexen-1-one (1934)

P. L. Hooper, A. K. Macbeth and J. R. Price, J. Chem. Soc., 1934, 1147 DOI: 10.1039/JR9340001147
Vascular endothelial growth factor acts as an osteolytic factor in breast cancer metastases to bone (2005)

Vascular endothelial growth factor (VEGF) is a proangiogenic cytokine that is expressed highly in many solid tumours often correlating with a poor prognosis. In this study, we investigated the expression of VEGF and its receptors in bone metastases from primary human breast tumours and further characterised its effects on osteoclasts in vitro. Breast cancer metastases to bone were immunohistochemically stained for VEGF, its receptors VEGFR1 and 2 (vascular endothelial growth factor receptor 1 and 2), demonstrating that breast cancer metastases express VEGF strongly and that surrounding osteoclasts express both VEGFR1 and VEGFR2. RAW 264.7 cells (mouse monocyte cell line) and human peripheral blood mononuclear cells (PBMCs) were cultured with VEGF, RANKL and M-CSF. VEGF and RANKL together induced differentiation of multinucleated, tartrate-resistant acid phophatase (TRAP)-positive cells in similar numbers to M-CSF and RANKL. The PBMCs were also able to significantly stimulate resorption of mineralised matrix after treatment with M-CSF with RANKL and VEGF with RANKL. We have shown that VEGF in the presence of RANKL supports PBMC differentiation into osteoclast-like cells, able to resorb substrate. Vascular endothelial growth factor may therefore play a role in physiological bone resorption and in pathological situations. Consequently, VEGF signalling may be a therapeutic target for osteoclast inhibition in conditions such as tumour osteolysis.
Phenotypic and Genetic Analysis of det2, a New Mutant That Affects Light-Regulated Seedling Development in Arabidopsis (1991)

Joanne Chory, Punita Nagpal, Charles A. Peto, Phenotypic and Genetic Analysis of det2, a New Mutant That Affects Light-Regulated Seedling Development in Arabidopsis, The Plant Cell, Vol. 3, No. 5 (May, 1991), pp. 445-459
[A study on cytokine levels and nitric oxide content in rabbit aqueous humor after lens extraction and intraocular lens implantation]. (2003)

The intraocular inflammation after intraocular lens implantation is closely related to the changes of cytokine levels and NO content in aqueous humor.
RUSE: Regressor Using Sentence Embeddings for Automatic Machine Translation Evaluation (2018)

We introduce the RUSE 1 metric for the WMT18 metrics shared task. Sentence embeddings can capture global information that cannot be captured by local features based on character or word N-grams. Although training sentence embeddings using small-scale translation datasets with manual evaluation is difficult, sentence embeddings trained from large-scale data in other tasks can improve the automatic evaluation of machine translation. We use a multi-layer perceptron regressor based on three types of sentence embeddings. The experimental results of the WMT16 and WMT17 datasets show that the RUSE metric achieves a state-of-the-art performance in both segment-and system-level metrics tasks with embedding features only.
Chromaticity Limitations of the Best Physically Realizable Three-Filter Photoelectric Colorimeter (1937)

The theoretical requirements to be met by a photoelectric colorimeter capable of yielding I.C.I, tristimulus values, and relationships between tristimulus values and instrumental reflectances are given. For practical reasons, the correct photoelectric colorimeter must be equipped with four filters. It is commonly believed that a three-filter photoelectric colorimeter would be generally suitable for color specification and color matching; this is tested from the theoretical standpoint, and it is shown that the best physically realizable three-filter photoelectric colorimeter would suffer a fundamental chromaticity limitation. Relationships between the displacements of instrumental points on the chromaticity diagram and errors in the “red,” green, and blue reflectances are given. Especial attention is given to errors originating in the assumption that the blue reflectance may be used in the evaluation of both the X and Z tristimulus values; maximal displacements associated with this assumption are given for a number of points on the diagram, and it is shown that actual chromaticity errors would be objectionably great for many colors of importance. The use of a three-filter photoelectric colorimeter as a color comparator is discussed.
Investigation of Industrial Polyurethane Foams Modified with Antimicrobial Copper Nanoparticles (2016)

Antimicrobial copper nanoparticles (CuNPs) were electrosynthetized and applied to the controlled impregnation of industrial polyurethane foams used as padding in the textile production or as filters for air conditioning systems. CuNP-modified materials were investigated and characterized morphologically and spectroscopically, by means of Transmission Electron Microscopy (TEM), and X-ray Photoelectron Spectroscopy (XPS). The release of copper ions in solution was studied by Electro-Thermal Atomic Absorption Spectroscopy (ETAAS). Finally, the antimicrobial activity of freshly prepared, as well as aged samples-stored for two months-was demonstrated towards different target microorganisms.
Fogo em veredas: avaliação de impactos sobre comunidades de Odonata (Insecta) (2011)

As veredas são fisionomias abertas do bioma Cerrado, que desempenham papel essencial na proteção de nascentes. Por outro lado, as veredas também são consideradas de grande importância para uso direto das populações rurais que habitam o Cerrado brasileiro. Estes conflitos de utilização das veredas são hoje um grande desafio para a conservação da biodiversidade. Neste estudo objetivou-se testar o efeito do fogo sobre a riqueza e composição de Odonatas (libélulas) em veredas queimadas e não-queimadas na Estação Ecológica Serra Geral do Tocantins (EESGT). A riqueza foi estimada para cada uma das veredas amostradas através do método não-paramétrico Jackknife de primeira ordem. A análise de espécies indicadoras foi feita pelo IndVal. A similaridade na composição da comunidade de Odonata foi obtida através do índice de Chao. No total foram amostradas 33 espécies de Odonata, distribuídas entre cinco famílias. Nenhuma das espécies de Odonata esteve associada especificamente a ambientes queimados ou não queimados. As veredas queimadas apresentaram uma maior similaridade na composição das comunidades de Odonata do que as veredas não queimadas e o mesmo padrão pode ser observado quando considerada apenas a subordem Zygoptera. Este trabalho com comunidades de Odonata demonstrou que há impacto do fogo sobre a composição de espécies da subordem Zygoptera que possui menor capacidade de dispersão. Isso reforça a idéia de que o fogo é conhecidamente uma das principais ameaças sobre as áreas protegidas do Cerrado e uma ameaça à manutenção da biodiversidade de veredas da EESGT. Caso decisões de uso e manejo do fogo sejam tomadas, que estas sejam, imprescindivelmente, acompanhadas de pesquisas de monitoramento de veredas na EESGT.\n\nPalavras-chave: campos úmidos; Cerrado; composição; conflitos; riqueza; unidade de conservação.
Embracing <i>Scholarship</i> in the Built Environment (2009)

An important objective of the UK Higher Education Academy is to provide for catalysts to facilitate greater sharing of knowledge about teaching and research issues. In part, the Academy was a respo...
Adaptive Fuzzy Sandia Frequency-Shift Method for Islanding Protection of Inverter-Based Distributed Generation (2012)

Sandia Frequency Shift (SFS) is one of the active islanding detection methods that rely on frequency drift to detect an islanding condition. Recently, SFS has been widely applied to inverter-based distributed generations due to its small Non-Detection Zone (NDZ). The NDZ in SFS method highly depends on its design parameters. Improper tuning of these parameters may result in failure of the method. In the proposed method in this paper, the load parameters are estimated online and the SFS parameter is adaptively tuned to eliminate NDZ using fuzzy load parameter estimation (FLPE) method. Simulation results verify the excellent performance of the proposed method.
Measured and calculated CD spectra of G‐quartets stacked with the same or opposite polarities (2007)

Circular dichroism (CD) spectroscopy is widely used to characterize the structures of DNA G-quadruplexes. CD bands at 200-300 nm have been empirically related to G-quadruplexes having parallel or antiparallel sugar-phosphate backbones. We propose that a more fundamental interpretation of the origin of the CD bands is in the stacking interactions of neighboring G-quartets, which can have the same or opposing polarities of hydrogen bond acceptors and donors. From an empirical summation of CD spectra of the d(G)5 G-quadruplex and of the thrombin binding aptamer that have neighboring G-quartets with the same and opposite polarities, respectively, the spectra of aptamers selected by the Ff gene 5 protein (g5p) appear to arise from a combination of the two types of polarities of neighboring G-quartets. The aptamer CD spectra resemble the spectrum of d(G3T4G3), in which two adjacent quartets have the same and two have opposite polarities. Quantum-chemical spectral calculations were performed using a matrix method, based on guanine chromophores oriented as in d(G3T4G3). The calculations show that the two types of G-quartet stacks have CD spectra with features resembling experimental spectra of the corresponding types of G-quadruplexes.
Reply: Simplified Quantification of Myocardial Flow Reserve with <sup>18</sup>F-Flurpiridaz: Validation with Microspheres in a Pig Model (2011)

REPLY: We appreciate the thoughtful letter from Drs. Johnson and Gould expressing their concerns with an extrapolation from our study that the ratio of standardized uptake values from stress and rest studies could serve as an index of myocardial flow reserve when a physical stress test is used ([1][
Cyclopropanes Derived from Diaryldiazomethanes. II. 3-Azabicyclo[3.1.0]- hexanes and Their Azaspiroquaternary Salts<sup>1</sup> (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCyclopropanes Derived from Diaryldiazomethanes. II. 3-Azabicyclo[3.1.0]- hexanes and Their Azaspiroquaternary Salts1RICHARD BALTZLY, NARIMAN B. MEHTA, PETER B. RUSSELL, RONALD E. BROOKS, EUGENE M. GRIVSKY, and ANNE M. STEINBERGCite this: J. Org. Chem. 1962, 27, 1, 213–218Publication Date (Print):January 1, 1962Publication History Published online1 May 2002Published inissue 1 January 1962https://pubs.acs.org/doi/10.1021/jo01048a054https://doi.org/10.1021/jo01048a054research-articleACS PublicationsRequest reuse permissionsArticle Views75Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Effect of Temperature and Mechanical Stress on Barrier Properties of Polymeric Films Used for Food Packaging (2007)

The permeance of carbon dioxide, oxygen, nitrogen, and air through commercial polymers based on polyethylene (PE), biaxially oriented polypropylene (BOPP), and polyamide (PA) used for food packaging is reported. The influence of temperature (from 10 to 60 ° C) and crease stress cycles (30, 50, 70, and 110) on gas permeance is also analyzed. Generally, the highest changes in gas permeance changes with increased stress cycles are observed with films having a metallized layer in the structure, namely BOPPcoex/BOPPcoex.met and, to a lesser extent, BOPPcoex.met/PE laminate. The lowest crease stress influence on barrier properties is obtained for PE film. In this case, the highest activation energy for the permeability coefficient (P) is obtained. Normal progressions of activation energies for P are: N 2 = Air>CO 2 >O 2 .
Immunoreactivity and receptor binding of mixed recombinants of human growth hormone and chorionic somatomammotropin. (1978)

The behavior in six radioligand assays of the recombinant obtained by the noncovalent complementation of the reduced and carbamoylmethylated 134-residue amino-terminal fragment of human growth hormore with the reduced and carbamoylmethylated 51-residue carboxyl-terminal fragment of human chorionic somatomammotropin was compared to that of the analogous recombinant of the 133-residue amino-terminal fragment of human chorionic somatomammotropin and the 51-residue carboxyl-terminal fragment of human growth hormone. The determinants for the hepatic growth hormone receptor binding and for the lactogenic receptor binding of human growth hormone are on the amino-terminal fragments. The antigenic determinants for both a monospecific antiserum to human growth hormone and a monospecific antiserum to human chorionic somatomammotropin also are on the amino-terminal fragments of their respective antigens. The mixed recombinant of the amino-terminal fragment of human growth hormone with the carboxyl-terminal fragment of human chorionic somatomammotropin retains full radioimmuno- and radioreceptor activity after lyophilization.
Moving belt radiator development status (1988)

Development of the Moving Belt Radiator (MBR) as an advanced space radiator concept is discussed. The ralative merits of Solid Belt (SBR), Liquid Belt (LBR), and Hybrid Belt (HBR) Radiators are described. Analytical and experimental efforts related to the dynamics of a rotating belt in microgravity are reviewed. The development of methods for transferring heat to the moving belt is discussed, and the results from several experimental investigations are summarized. Limited efforts related to the belt deployment and stowage, and to fabrication of a hybrid belt, are also discussed. Life limiting factors such as seal wear and micrometeroid resistance are identified. The results from various MBR point design studies for several power levels are compared with advanced Heat Pipe Radiator technology. MBR designs are shown to compare favorable at both 300 and 1000 K temperature levels. However, additional effort will be required to resolve critical technology issues and to demonstrate the advantage of MBR systems.
Electromagnetic Scattering by a Conducting Cylinder Coated with Metamaterials (2003)

The electromagnetic scattering from a conducting cylinder coated with metamaterials, which have both negative permittivity and permeability, is derived rigorously by using the classic separation of variables technique. It is found that a conducting cylinder coated with metamaterials has anomalous scattering cross section compared to that coated with conventional dielectric materials. Numerical results are presented and discussed for the scattering cross section of a conducting cylinder coated with metamaterials. 1 Introduction 2 Formulation 3 Numerical Results and Discussion 4 Conclusion References
PROLONGATION OF THE SURVIVAL OF MURINE CARDIAC ALLOGRAFTS BY THE VITAMIN D3 ANALOGUE 1,25-DIHYDROXY-Δ16-CHOLECALCIFEROL (1992)

LEMIRE, JACQUES M.1; ARCHER, D. CLAY2; KHULKARNI, ANIL3; INCE, ANN3; UsKOKOvIc, MILAN R.4; STEPROWSKI, STANISLAW3 Author Information
Luteinizing hormone-releasing hormone (LHRH) in rat prostate: characterization of LHRH peptide, messenger ribonucleic acid expression, and molecular processing of LHRH in intact and castrated male rats. (1993)

Continuous administration of LHRH agonist suppresses the pituitary-gonadal axis, achieving chemical castration. Thus, LHRH agonist has been used as an alternative (to surgical castration) for the treatment of steroid-dependent prostate cancer. However, recent reports have demonstrated that LHRH agonist had a direct inhibiting effect on prostate cancer cell proliferation and that cancerous prostate tissue contained a LHRH-like peptide. In this paper we are reporting for the first time that the normal rat ventral prostate contained immunoactive and bioactive LHRH as well as its precursor molecule, pro-LHRH. Our investigation showed that the LHRH concentration in prostate increased 2 weeks after castration from 1.68 +/- 0.09 to 3 +/- 0.2 pg/mg tissue (P < 0.001). At the same time, the concentration of pro-LHRH decreased from 149 +/- 6.5 to 68 +/- 6.8 pg/mg tissue (P < 0.001). Furthermore, intact rat prostate expressed LHRH mRNA, which increased 13-fold 2 weeks after castration. In summary, the prostate of intact Sprague-Dawley rats has the capacity to produce the LHRH precursor and process it to the mature decapeptide, and this production/processing increases significantly after castration.
Comparison of an indirect immunofluorescence assay, western blot analysis, and a commercially available ELISA for detection of Ehrlichia canis antibodies in canine sera (2006)

The discrepancy between E canis-IFA, WB analyses, and the commercially available ELISA results for the low-titer serum samples may be related to a high IFA sensitivity or, more likely, a lack of specificity associated with cross-reactivity among Ehrlichia spp.
Comparison of Clinical Outcomes and Adverse Events Associated With Glucose-Lowering Drugs in Patients With Type 2 Diabetes (2016)

Among adults with type 2 diabetes, there were no significant differences in the associations between any of 9 available classes of glucose-lowering drugs (alone or in combination) and the risk of cardiovascular or all-cause mortality. Metformin was associated with lower or no significant difference in HbA1C levels compared with any other drug classes. All drugs were estimated to be effective when added to metformin. These findings are consistent with American Diabetes Association recommendations for using metformin monotherapy as initial treatment for patients with type 2 diabetes and selection of additional therapies based on patient-specific considerations.
Cellular compatibility of RGD-modified chitosan nanofibers with aligned or random orientation (2010)

Aligned and randomly oriented chitosan nanofibers were prepared by electrospinning. The fibers were modified with the RGD cell-adhesive peptide through a heterobifunctional crosslinker containing a segment of poly(ethylene glycol) (PEG). PEG rendered the surface hydrophilic and provided flexible spacers, allowing the preservation of the bioactivity of further captured RGD peptides. NIH 3T3 cells were used to test the cellular compatibility of these chitosan nanofibrous scaffolds. Cell morphology and viability were investigated by SEM, fluorescent staining and cell counting. The results indicate that RGD-modified surfaces significantly improve the cellular compatibility of chitosan nanofibers and suggest a good candidate as a scaffold employed in tissue engineering.