gebhart/patrepeval huggingface dataset:
Phospholamban Phosphorylation in Intact Ventricles (1989)

Phospholamban is the major membrane protein of the heart phosphorylated in response to beta-adrenergic stimulation. In cell-free systems, cAMP-dependent protein kinase catalyzes exclusive phosphorylation of serine 16 of phospholamban, whereas Ca2+/calmodulin-dependent protein kinase gives exclusive phosphorylation of threonine 17 (Simmerman, H. K. B., Collins, J. H., Theibert, J. L., Wegener, A. D., and Jones, L. R. (1986) J. Biol. Chem. 261, 13333-13341). In this work we have localized the sites of phospholamban phosphorylation in intact ventricles treated with the beta-adrenergic agonist isoproterenol. Isolation of phosphorylated phospholamban from 32P-perfused guinea pig ventricles, followed by partial acid hydrolysis and phosphoamino acid analysis, revealed phosphorylation of both serine and threonine residues. At steady state after isoproterenol exposure, phospholamban contained approximately equimolar amounts of these two phosphoamino acids. Two major tryptic phosphopeptides containing greater than 90% of the incorporated radioactivity were obtained from phospholamban labeled in intact ventricles. The amino acid sequences of these two tryptic peptides corresponded exactly to residues 14-25 and 15-25 of canine cardiac phospholamban, thus localizing the sites of in situ phosphorylation to serine 16 and threonine 17. Phosphorylation of phospholamban at two sites in heart perfused with isoproterenol was supported by detection of 11 distinct mobility forms of the pentameric protein by use of the Western blotting method, consistent with each phospholamban monomer containing two phosphorylation sites, and with each pentamer containing from 0 to 10 incorporated phosphates. Our results localize the sites of in situ phospholamban phosphorylation to serine 16 and threonine 17 and, furthermore, are consistent with the phosphorylations of these 2 residues being catalyzed by cAMP- and Ca2+/calmodulin-dependent protein kinases, respectively.
EPIDEMIOLOGY OF ADENOVIRUS-ASSOCIATED VIRUS INFECTION IN A NURSERY POPULATION1 (1968)

Journal Article EPIDEMIOLOGY OF ADENOVIRUS-ASSOCIATED VIRUS INFECTION IN A NURSERY POPULATION Get access NEIL R. BLACKLOW, NEIL R. BLACKLOW Search for other works by this author on: Oxford Academic PubMed Google Scholar M. DAVID HOGGAN, M. DAVID HOGGAN Search for other works by this author on: Oxford Academic PubMed Google Scholar ALBERT Z. KAPIKIAN, ALBERT Z. KAPIKIAN Search for other works by this author on: Oxford Academic PubMed Google Scholar JOAN B. AUSTIN, JOAN B. AUSTIN Search for other works by this author on: Oxford Academic PubMed Google Scholar WALLACE P. ROWE WALLACE P. ROWE Search for other works by this author on: Oxford Academic PubMed Google Scholar American Journal of Epidemiology, Volume 88, Issue 3, November 1968, Pages 368–378, https://doi.org/10.1093/oxfordjournals.aje.a120897 Published: 01 November 1968 Article history Received: 13 June 1968 Published: 01 November 1968
Spectral domain analysis of a square microstrip spiral antenna (2002)

An Archimedean two-wire square spiral antenna is studied numerically by the spectral domain method. Complete antenna characteristics including input impedance, radiation efficiency, radiation pattern, and axial ratio are computed and presented. The goal of the authors' work is to design a microstrip spiral antenna operating at 8.0 GHz.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The Angioguard™ embolic protection device (2008)

Endovascular management of cardiovascular disease is quickly becoming a more popular treatment. The effectiveness in using embolic protection devices (EPDs), such as the Angioguard XP filter, during carotid artery stenting (CAS) is a topic of ongoing controversy and scrutiny. Early clinical results indicate that EPDs can reduce complications associated with CAS. However, the incidence of stroke and postprocedural embolic events are statistically similar when comparing CAS with the gold standard in carotid stenosis repair, carotid endarterectomy (CEA). The focus of this manuscript is the critical evaluation of Angioguard XP with respect to numerous in vitro and ex vivo experiments, and clinical trials that have been conducted by the authors and other researchers to investigate the efficacy of EPDs with the objective of suggesting engineering design considerations for future generations of these devices. Angioguard XP has had mixed performance outcomes in in vitro testing reported in the literature. In our laboratory, this device had undesirable measures of performance in bench-top testing protocols using in vitro flow models. Technical considerations relevant to design of EPDs, such as ideal pore size, effective wall apposition in tortuous geometry and maximization of capture efficiency have not been addressed adequately in the literature. It is likely that in the future both CAS and CEA will coexist as potential forms of treatment in the clinical management of cerebrovascular disease.
Synthesis of α-Cyclopropyl-β-homoprolines (2009)

1-(2-Pyrrolidinyl)cyclopropanecarboxylic acids (alpha-cyclopropyl-beta-homoprolines) were prepared by 1,3-dipolar cycloadditions of cyclic nitrones onto bicyclopropylidene followed by trifluoroacetic acid induced thermal fragmentative rearrangement. With the use of enantiopure pyrroline N-oxides derived from easily available chiral pool molecules, beta-homoprolines were formed with high stereocontrol. The incorporation of one of these new cyclic beta-amino acids into a simple tripeptide was also evaluated. In particular, the sterically hindered nitrogen atom of the highly substituted pyrrolidine 30 was smoothly acylated through the intermediate formation of a mixed anhydride.
Bone Marrow &ndash; Home of Versatile Stem Cells (2008)

SUMMARY: Bone marrow (BM) has been for many years primarily envisioned as the 'home organ' of hematopoietic stem cells (HSC). In this review we will discuss current views of the BM stem cell compartment and present data showing that BM in addition to HSC also contains a heterogeneous population of non-hematopoietic stem cells. These cells have been variously described in the literature as i) endothelial progenitor cells (EPC), ii) mes-enchymal stem cells (MSC), iii) multipotent adult progenitor cells (MAPC), iv) marrow-isolated adult multilineage inducible (MIAMI) cells, v) multipotent adult stem cells (MACS) and vi) very small embryonic-like (VSEL) stem cells. It is likely that in many cases similar or overlapping populations of primitive stem cells in the BM were detected using different experimental strategies and hence were assigned different names.
Clinical, laboratory, radiographic, and histopathologic features of methotrexate‐associated lung injury in patients with rheumatoid arthritis. A multicenter study with literature review (1997)

MTX lung injury is most often a subacute process, in which symptoms are commonly present for several weeks before diagnosis. Approximately 50% of the cases are diagnosed within 32 weeks from initiation of MTX treatment. A patient who recovers from MTX lung injury should not be re-treated. Earlier recognition and drug withdrawal may avoid the serious and sometimes fatal outcome that has been observed in this and other studies.
Oral Immunization of Rainbow Trout (<i>Salmo gairdneri</i>) Against an Etiologic Agent of "Redmouth Disease" (1965)

Rainbow trout were fed a pelleted diet containing killed cells of the etiologic agent of a bacterial disease, redmouth. These fish in addition to appropriate controls were subsequently challenged with virulent homologous organisms. Ninety per cent of the redmouth immunized fish survived the basic challenge using virulent organisms in contrast to 20% survival for the controls. Multiple challenge doses at increased levels also are discussed.
[Therapy of the unstable thorax in serial fractures of the ribs]. (1978)

The histories of patients with flail chest and respiratory insufficiency caused by blunt chest injury have been analyzed. The first group represented patients with surgical stabilization of 3-4 ribs by introduction of "Rehbein plates" into the medullary cavity (10 patients 1972-1975). The patients of the second group have been supported by controlled mechanical respiration (11 patients 1972-1975). Patients with chest and further injuries (polyblessés) of comparable degree have been selected for both groups. The two groups were compared with regard to duration of intubation and artificial ventilation (average of 8.8 days for the operated and 21.4 days for the mechanically ventilated patients), stay in the intensive care unit (15.2 days after operation and 28.3 days for treatment by respirator) and average total hospitalization time (33.5 days after surgical management and 54.2 days after nonsurgical treatment). Severe bronchial infections caused by hospital germs have occurred more frequently in patients on long-term intubation and mechanical respiration. The average age of patients was almost the same in both groups. The technique of surgical stabilization of the ribs is described, and the advantages and limits of surgical and conservative management of respiratory insufficiency caused by flail chest are discussed.
Fluid Flow in Low Permeable, Porous Media (1988)

Migration of hydrocarbons deals with the subsequent movement of petroleum after expulsion from the source rock through water saturated reservoirs or through permeability created by fractures and faults. Although the underlying principles that control the fluid movement in porous media (reservoirs) are well understood by reservoir engineers, less is known about the flow characteristics in low-permeable, porous media, such as clays and shales. For flow considerations, the primary parameters are porosity, permeability and the fluid potential gradients. For clays and shales, these parameters are poorly known; yet these control the time periods during which fluid flow occurs in sedimentary basins (100 years to 100 million years). In this paper, I examine the parametric dependence of the time constantsof fluid flow in low permeability sediments on its porosity and permeability. This is accomplished in two parts. In the first part, a technique is presented to investigate the effect of fluid flow in shales which causes undercompaction and buildup of fluid pressures in excess of normal hydrostatic pressure. The technique is pre-drill in nature; it uses seismic velocity analysis of common depth point gather of surface seismic data and is based on the concept developed by Hottmann and Johnson (1965) and Pennebaker (1968). In the second part of the paper, the flow characteristics are discussed in the basin scale. I develop a model that describes the fluid flow in a continuously accreting and subsiding clastics basins, such as the Gulf of Mexico. I examine the pressure characteristics of such a basin by digital simulations and study the effect of the permeability variation of shales on the geologic time dependence of the fluid flux in the sediments, the basin subsidence rate and the pressure buildup with depth. The model incorporates both mechanical compaction and burial diagenesis involving smectite to illite conversion of shales. The latter is based on a kinetic theory of chemical reaction in which the time-temperature history is provided by the solution of an appropriate heat conduction equation. This model of geopressure has a practical application since it deals with the generation and maintenance of abnormally high fluid pressures over geologic time and impacts the hydrocarbon migration in clastic basins.
Intra‐ and Intermolecular Reactions of Indoles with Alkynes Catalyzed by Gold. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Graph Isomorphism is Not AC0-Reducible to Group Isomorphism (2013)

We give a new upper bound for the Group and Quasigroup Isomorphism problems when the input structures are given explicitly by multiplication tables. We show that these problems can be computed by polynomial size nondeterministic circuits of unbounded fan-in with O (log log n ) depth and O (log 2 n ) nondeterministic bits, where n is the number of group elements. This improves the existing upper bound for the problems. In the previous bound the circuits have bounded fan-in but depth O (log 2 n ) and also O (log 2 n ) nondeterministic bits. We then prove that the kind of circuits from our upper bound cannot compute the Parity function. Since Parity is AC 0 -reducible to Graph Isomorphism, this implies that Graph Isomorphism is strictly harder than Group or Quasigroup Isomorphism under the ordering defined by AC 0 reductions. We extend this result to the stronger ACC 0 [ p ] reduction and its randomized version.
Optimized Multicast Service Management in a Mobile WiMAX TV System (2009)

WiMAX technology is a good candidate to provide broadcast TV services for mobile users because it supports QoS based multicasting functionality. To provide multicast-based TV services over the mobile WiMAX network, a multicast session setup involves both MAC-layer and IP-layer multicast management. However, in mobile environment, IP-layer multicast management entails service interruption due to unreliable wireless transmission, and disrupts mobile terminal's power-saving mode. In this paper, we propose a cross-layer multicast service management scheme that can not only avoid the service interruption and power-saving mode disruption but also reduce the bandwidth consumption for IP-layer multicast signaling. Simulation results demonstrate that the scheme can eliminate the unnecessary power consumption caused by IP-layer multicast signaling, and improve the wireless uplink throughput as well. We also study, by simulation, the influence of the multicast management signaling procedures on channel switching time that is a major performance indication for mobile TV services.
Perception of Self-motion and Presence in Auditory Virtual Environments (2004)

Apart from inducing a high sense of presence, creating a sensation of self-motion is often a key issue of many Virtual Reality applications. However, self-motion perception (vection) has been primarily investigated for visual stimuli. This study explored the possibility of inducing vection by realistic auditory stimuli. Furthermore, influence of various audio design parameters on auditory-induced vection was studied. The results suggest that sound source characteristic is a primary determinant of auditory-induced vection, especially for an environment with only a single sound source. However, it was also found that the type of sound source may play less of a role when the environment contains multiple sound sources. Auditory-induced vection is also depending on whether or not room acoustic cues are included in the simulation. It is however likely that it is the interaction between type of sound source and the environment that is important. Keywords--- Self-motion perception, Vection,
Permeability of shaly sands (1999)

The permeability of a sand shale mixture is analyzed as a function of shale fraction and the permeability of the two end‐members, i.e., the permeability of a clay‐free sand and the permeability of a pure shale. First, we develop a model for the permeability of a clay‐free sand as a function of the grain diameter, the porosity, and the electrical cementation exponent. We show that the Kozeny‐Carman‐type relation can be improved by using electrical parameters which separate pore throat from total porosity and effective from total hydraulic radius. The permeability of a pure shale is derived in a similar way but is strongly dependent on clay mineralogy. For the same porosity, there are 5 orders of magnitude of difference between the permeability of pure kaolinite and the permeability of pure smectite. The separate end‐members' permeability models are combined by filling the sand pores progressively with shale and then dispersing the sand grains in shale. The permeability of sand shale mixtures is shown to have a minimum at the critical shale content at which shale just fills the sand pores. Pure shale has a slightly higher permeability. Permeability decreases sharply with shale content as the pores of a sand are filled. The permeability of sand shale mixtures thus has a very strong dependence on shale fraction, and available data confirm this distinctive shale‐fraction dependence. In addition, there is agreement (within 1 order of magnitude) between the permeabilities predicted from our model and those measured over 11 orders of magnitude from literature sources. Finally, we apply our model to predict the permeabilities of shaly sand formations in the Gulf Coast. The predictions are compared to a data set of permeability determination made on side‐wall cores. The agreement between the theoretical predictions and the experimental data is very good.
Automatic Compilation of C Applications for FPGA-Based Hardware Acceleration (2011)

Advancement in design tools is necessary to bridge the widening productivity gap between hardware design and software development in state-of-the-art Field Programmable Gate Arrays (FPGA). We present a design exploration framework that automatically compiles C applications to realize efficient custom co-processor structures for hardware acceleration on the reconfigurable logic. We show that the proposed design exploration framework can automatically generate Register Transfer Level (RTL) codes from C-functions that outperform the commercial Altera C2H RTL generator by about 40% in terms of average area-time product.
Surface passivation and microroughness of (100) silicon etched in aqueous hydrogen halide (HF, HCl, HBr, HI) solutions (1995)

The surface reactivity of hydrogen-passivated, HF-last-cleaned Si(100) toward aqueous HX and HF/HX (X=Cl, Br, I) is examined. The HCl and HBr solutions are found to leave the HF-cleaned bare Si surface unaltered, while the HI solution reoxidizes the hydrogen-passivated surface. Treatments in aqueous HF/HCl or HF/HBr solutions lead to the same surface passivation and surface microroughness as for HF-cleaned surfaces. In the HF/HI solution, a simultaneous oxidation and etching process takes place, resulting in an increased (111) microfaceting of the Si(100) surface.
Batting the Ball (1963)

The velocity vector of a ball struck by a bat is a stated function of the ball and bat velocities, bat orientation, and certain constants. In the light of the equations of the collision, the operation and the consequences of swinging the bat are analyzed, and the role of the constants is discussed.
Step-by-step guide to the realization of advanced optical tweezers (2015)

Since the pioneering work of Arthur Ashkin, optical tweezers (OT) have become an indispensable tool for contactless manipulation of micro- and nanoparticles. Nowadays OT are employed in a myriad of applications demonstrating their importance. While the basic principle of OT is the use of a strongly focused laser beam to trap and manipulate particles, more complex experimental setups are required to perform novel and challenging experiments. With this article, we provide a detailed step-by-step guide for the construction of advanced optical manipulation systems. First, we explain how to build a single-beam OT on a homemade microscope and how to calibrate it. Improving on this design, we realize a holographic OT, which can manipulate independently multiple particles and generate more sophisticated wavefronts such as Laguerre–Gaussian beams. Finally, we explain how to implement a speckle OT, which permits one to employ random speckle light fields for deterministic optical manipulation.
Real-Time Estimation of Drivable Image Area based on Monocular Vision (2013)

International audience
Effect of processing parameters on the microstructure and thermal conductivity of diamond/Ag composites fabricated by spark plasma sintering (2010)

有 50 vol.% 钻石的钻石 / 金属 composites 被火花血浆 sintering (SPS ) 作为加强作为一个矩阵和钻石粒子用纯 Ag 生产了。混合过程的三种粉末被用来准备 diamond/Ag 粉末的混合：没有 milling 媒介，湿混合并且磁性的相配，弄干混合。随后，他们都被 SPS 在各种各样的处理参数巩固生产体积 diamond/Ag composites。当时，样品是对待以便获得更高热的传导性的热。在混合粉末，微观结构和 composites 的热传导性的形态学上处理参数的效果被比较试验性的数据调查。它表明粒子是容易的聚结，混合粉末的分发由干燥混合方法是不同类的，并且湿混合方法是太复杂的。最有利的混合进程是磁性的粉末能同质地被哪个混合相配， composites 由在 composites 之中的最高相对的密度和最好的热传导性由不同进程准备了的参数能获得的处理的优化 SPS 准备。磁性的相配 diamond/Ag composites 甚至让 23% 由 SPS 与纯银 sintered 相比在热电导率增加。
The electrochemistry of hydrogen peroxide on evaporated gold/palladium composite electrodes. Manufacture and electrochemical characterization (1995)

Abstract A thin‐film composite metal electrode is described for the amperometric measurement of hydrogen peroxide. By thermally evaporating a 27 μM layer of gold/palladium through a copper mask onto a plastic substrate a number of chemically equivalent sensing elements can be prepared. On these electrodes, hydrogen peroxide can be oxidized at a voltage of 0.4V (SCE). A model for the oxidation of peroxide at these electrodes is described based upon reversible binding of hydrogen peroxide to electrochemically generated palladium oxide sites.
Problems of materialism (2003)

Timpanaro’s most general definition of the fundamentals of materialism can be accepted, at first sight, as it stands: ‘By materialism we understand above all acknowledgment of the priority of nature over “mind”, or if you like, of the physical level over the biological level, and of the biological level over the socio-economic and cultural level; both in the sense of chronological priority (the very long time which supervened before life appeared on earth, and between the origin of life and the origin of man), and in the sense of the conditioning which nature still exercises on man and will continue to exercise at least for the foreseeable future’ (Timpanaro 1975:34). It is difficult to see how anyone could deny the intention of the first proposition, though it is better expressed in its specifying than in its general terms. The cautionary notation of ‘mind’ needs to be extended also to ‘nature’, but there can be no serious argument against the existence of a physical world before life and of other life-forms before man. And it is important that while these facts are never denied, within any relevant area of argument, they are quite often dismissed as banalities which have little practical bearing on the more interesting questions that lie ahead. One of the excuses for this impatience is that the general terms used to summarize the enormous and complex body of facts, on which the propositions necessarily rest, are shot through with inherently subsequent interpretations of a philosophical and cultural character. Thus it is not unproblematic to say that ‘nature’ has ‘priority over’ ‘mind’, but we can only approach these problems in good faith if we have, with full seriousness, taken the weight of the astronomical, geological and biological evidence before entering the more congenial ground of the humanist categories. And it is in this area, at first sight, that the effect of the declining contribution of the natural sciences to the general culture of Marxism has been most apparent. While the sense of proportion imposed by this fundamental materialism is either forgotten ordismissed as a preliminary banality, the way is indeed open for every kind of obscurantism and evasion.