gebhart/patrepeval huggingface dataset:
Performance of a 2.5 THz Receiver Front-End for Spaceborne Applications (1999)

To explore the difference of curative effect between different treatment modalities, in order to provide reference for the treatment of aortic intramural hematoma (IMH). 168 patients with aortic intramural hematoma diagnosed and treated from January 2010 to July 2020 were selected in the Second Affiliated Hospital of Nanchang University. Among them, 48 patients were diagnosed with Stanford A aortic intramural hematoma and 120 were diagnosed with Stanford B aortic intramural hematoma. According to the therapeutic methods, patients were divided into conservative treatment group and endovascular treatment group (TEVAR). For endovascular treatment group, according to the different timing of surgery, can be divided into acute phase group (onset within 72 h) and non-acute phase group (time of onset > 72 h).The clinical data and follow-up data were collected and analyzed by variance analysis and χ<sup>2</sup> test. There were 168 patients diagnosed with aortic intramural hematoma 39 of them were (81.25%) Stanford A aortic intramural hematoma patients with pleural or pericardial effusion. For patient with Stanford A aortic intramural hematoma, endovascular treatment was performed in 15 patients (31.2%), and 33 cases (68.8%) for conservative treatment. The average follow-up (24.9 ± 13.9) was months. There were 120 patients with Stanford type B aortic intramural hematoma (71.4%), 60 patients received endovascular treatment (50%), and 60 patients (50%) received conservative treatment, with an average follow-up of (27.8 ± 14.6) months. For Stanford A type aortic intramural hematoma patients when the maximum aortic diameter ≥ 50 mm or hematoma thickness ≥ 11 mm, with high morbidity and mortality, positive endovascular treatment can reduce complications and death. For patients with Stanford type B aortic intramural hematoma, when the maximum aortic diameter ≥ 40 mm or hematoma thickness ≥ 10 mm, with high morbidity and mortality, positive endovascular treatment can reduce complications and death. Both Stanford type A and B aortic intramural hematoma patients could benefit from the endovascular treatment when the initial maximum aortic diameter is ≥ 50 mm or the hematoma thickness is ≥ 11 mm.
Cycles: A Simulation Tool for Studying Cyclic Neural Networks (1987)

A computer program has been designed and implemented to allow a researcher to analyze the oscillatory behavior of simulated neural networks with cyclic connectivity. The computer program, implemented on the Texas Instruments Explorer /Odyssey system, and the results of numerous experiments are discussed.

The program, CYCLES, allows a user to construct, operate, and inspect neural networks containing cyclic connection paths with the aid of a powerful graphics-based interface. Numerous cycles have been studied, including cycles with one or more activation points, non-interruptible cycles, cycles with variable path lengths, and interacting cycles. The final class, interacting cycles, is important due to its ability to implement time-dependent goal processing in neural networks.
Renal Metabolism of C-Peptide in Man* (1987)

Renal metabolism of C-peptide was studied in nine nondiabetic nonobese patients with normal renal function by the arterial-venous difference technique before and after the oral administration of an amino acid mixture simulating an animal protein meal. In the basal state, the kidney removed 25.7 +/- 7.5% (+/- SD) of the arterial plasma C-peptide. Renal uptake was approximately 7-fold greater than urinary excretion, and thus, more than 85% of the amount extracted was metabolized by the kidney. Renal C-peptide clearance was very high and approximated the glomerular filtration rate, whereas urinary C-peptide clearance was only 14% of its renal clearance. Shortly after amino acid ingestion, arterial C-peptide levels increased by 107%, and C-peptide renal fractional extraction, uptake, and net metabolism also increased markedly (67%, 278%, and 328%, respectively); urinary clearance and excretion did not change. Renal clearance became 2-fold greater than the glomerular filtration rate, indicating that in this phase the kidney removed substantial amounts of C-peptide from peritubular blood as well as by filtration. Both renal uptake and urinary excretion of C-peptide were related to its arterial levels (P less than 0.001 and P less than 0.05, respectively), but renal uptake increased much more than urinary excretion for each increment in arterial C-peptide levels. These results indicate that renal C-peptide metabolism is considerable in the postabsorptive state and is even more marked during the postprandial period. The kidney, therefore, plays a key role in both the regulation of circulating plasma levels and the metabolic clearance of C-peptide.
Next-Generation Robotic Spine Surgery: First Report on Feasibility, Safety, and Learning Curve (2018)

We found that next-generation robotic spine surgery was safe and feasible with reliable and precise accuracy and a minimal learning curve. As this technology improves, further novel applications are expected to develop. Further research is needed to determine long-term efficacy.
Incorporation of curcumin in lipid based delivery systems and assessment of its bioaccessibility (2012)

Curcumin, the major curcuminoid compound from turmeric (Curcuma longa) is a well-studied nutraceutical with many health promoting biological properties. The benefits of curcumin greatly dependon its solubilization (bioaccessibility) and subsequent absorption through cell lining so that it can reach systemic/general circulation. Unfortunately, curcumin has low water solubility and undergoes rapid metabolism on oral delivery. Lipids have shown to affect the absorption of poorly soluble nutraceuticals such as curcumin by enhancing solubilization in the intestinal milieu through alterations to the composition and character of the colloidal environment –e.g. vesicles, mixed micelles and micelles when delivered orally. Thus, the purpose ofthis study was to formulate threelipid-based delivery systems with curcuminoids –gel like emulsions, nanoemulsions andorganogels, and investigate their impact on in vitro solubilization or bioaccessibility. Curcumin was dissolved in MC T oil with the help of Span 20 to be used as the lipid phase. Gel-like emulsions, nanoemulsions andorganogelswere then formulated using the curcumin-MCT oil lipid phase using different types of sugar esters as organogelators and emulsifiers. The organogels and gel-like emulsions are viscoelastic in naturewith a solid dominant behaviorwhich was supported by the rheological data. Optical and fluorescence microscopic imaging helped understand the morphology ofcurcumin inthe lipidbased delivery systemsas well as the systems themselves. Digital scanning calorimetry was used to study the phase transitionsthat occurin the systems. The bioaccessibilityof the different lipid based delivery systemswas evaluated using in vitrolipolysis experiments (dynamic pH stat lipid digestion model). Results suggest that lipid based delivery systems have more bioaccessibility when compared to that of unformulated curcuminoids. The bioaccessibility of curcumin increased at least 6.4 folds when it was incorporated in a lipid based delivery system as compared to unformulated curcuminoids.O ut of the three systems tested, gel-like emulsions had the highest stability and thus can be good candidate for incorporation and delivery of curcumin.
Photoresponsive Monodisperse Cholesteric Liquid Crystalline Microshells for Tunable Omnidirectional Lasing Enabled by a Visible Light‐Driven Chiral Molecular Switch (2014)

A self-organized, phototunable 3D photonic superstructure is fabricated from a photoresponsive 1D liquid crystal using microfluidics. The resulting microshells are water–oil–water double emulsions, in which the oil phase consists of the photoresponsive liquid crystals. The cholesteric microshells exhibit band-edge lasing in all directions, and the wavelength of the resultant band-edge laser is tuned via the pumping laser, causing photoisomerization of the chiral molecular switch.
Single Injection Depot Progesterone Prior to Surgery and Survival in Women with Operable Breast Cancer: A Randomized Controlled Trial. (2009)

Abstract Background:The relationship between timing of surgery during menstrual cycle and survival in women with operable breast cancer (OBC) has been a subject of much debate. A meta-analysis of 37 retrospective studies revealed a modest survival benefit of 15%±8(2P=0.003) for those operated during progestogenic phase, whereas three prospective studies did not show any difference. Another meta-analysis of effect of circulating progesterone at the time of surgery showed a 53%±4(2P&lt;0.001) improvement in survival when progesterone levels were high. The effect was confined to women with tumours that harboured lymph node metastasis(LN mets). We tested the effect of pharmacological induction of a progestogenic environment at the time of surgery on survival in women with OBC in a randomized controlled trial.Methods: One thousand women with OBC stratified by menopausal status and tumour size were randomly assigned to standard treatment (control) or an additional injection of depot preparation of hydroxy-progesterone(500 mg) 4-14 days prior to definitive surgery (treatment). Standard international guidelines were followed for adjuvant treatment. The primary endpoints were local, regional or distant recurrence(DFS) and secondary endpoint was death. Univariate comparison between treatment and control groups was performed using Kaplan Meier analysis and log rank test. A planned stratified analysis by lymph node status was also carried out. Cox proportional hazard model was used to assess the impact of tumour size, LN mets, menopausal status, treatment and an interaction between treatment and LN mets on DFS.Results: At median follow up of 65 months, 273 recurrences and 188 deaths have been recorded. In 982 eligible women DFS was 74% in treatment group and 70% in control group (RR=0.82, CI=0.67-1.08, P=0.195) while in women with LN mets DFS was 64.7% in treatment group and 54.6% in control group (RR=0.73,CI=0.54-0.97 p = 0.03). OAS was 81.5% in treatment arm and 80.2% in control arm (OR=0.94,CI=0.70-1.25, p=0.65) and, in women with LN mets, 76.3% in treatment arm and 69.9 % in control group (RR=0.74,CI=0.52-1.06, p=0.104). A Cox proportional hazard model for DFS revealed a significant impact of lymph node metastases (RR=2.22, CI=1.58-3.11, p=0.0005], hormone receptor positivity (RR=1.47,CI=1.15-1.87, p=0.002), and the interaction term between treatment and lymph node metastases (RR=1.15, CI=1.01-1.32, p=0.039) .Conclusions:A progestogenic milieu at the time of surgery significantly improves DFS in women with OBC and lymph node metastases. This could be a simple and inexpensive intervention for women with OBC, more so in developing world where lymph node positivity is high. A short term pre-operative intervention could be a novel window to explore impact of new drugs in a cost-effective manner. [NCT00123669]. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 72.
Persistent reovirus infections of L cells select mutations in viral attachment protein sigma1 that alter oligomer stability (1996)

During maintenance of L-cell cultures persistently infected with reovirus, mutations are selected in viruses and cells. Cells cured of persistent infection support growth of viruses isolated from persistently infected cultures (PI viruses) significantly better than that of wild-type (wt) viruses. In a previous study, the capacity of PI virus strain L/C to grow better than wt strain type 1 Lang (T1L) in cured cells was mapped genetically to the S1 gene (R. S. Kauffman, R. Ahmed, and B. N. Fields, Virology 131:79-87, 1983), which encodes viral attachment protein sigma1. To investigate mechanisms by which mutations in S1 confer growth of PI viruses in cured cells, we determined the S1 gene nucleotide sequences of L/C virus and six additional PI viruses isolated from independent persistently infected L-cell cultures. The S1 sequences of these viruses contained from one to three mutations, and with the exception of PI 2A1 mutations in each S1 gene resulted in changes in the deduced amino acid sequence of sigma1 protein. Using electrophoresis conditions that favor migration of sigma1 oligomers, we found that sigma1 proteins of L/C, PI 1A1, PI 3-1, and PI 5-1 migrated as monomers, whereas sigma1 proteins of wt reovirus and PI 2A1 migrated as oligomers. These findings suggest that mutations in sigma1 protein affecting stability of sigma1 oligomers are important for the capacity of PI viruses to infect mutant cells selected during persistent infection. Since no mutation was found in the deduced amino acid sequence of PI 2A1 sigma1 protein, we used T1L X PI 2A1 reassortant viruses to identify viral genes associated with the capacity of this PI virus to grow better than wt in cured cells. The capacity of PI 2A1 to grow better than T1L in cured cells was mapped to the S4 gene, which encodes outer-capsid protein sigma3. This finding suggests that in some cases, mutations in sigma3 protein in the absence of sigma1 mutations confer growth of PI viruses in mutant cells. To confirm the importance of the S1 gene in PI virus growth in cured cells, we used T1L X PI 3-1 reassortant viruses to genetically map the capacity of this PI virus to grow better than wt in cured cells. In contrast to our results using PI 2A1, we found that growth of PI 3-1 in cured cells was determined by the sigma1-encoding S1 gene. Given that the sigma1 and sigma3 proteins play important roles in reovirus disassembly, findings made in this study suggest that stability of the viral outer capsid is an important determinant of the capacity of reoviruses to adapt to host cells during persistent infection.
Histology Grade Is Independently Associated With Relapse Risk in Patients With Ulcerative Colitis in Clinical Remission: A Prospective Study (2016)

Histology grade has the strongest association with the risk of clinical relapse in patients with UC who are in clinical remission. Consideration should be given to including this end point in evaluating therapy for UC.
Spontaneous Assembly of Magnetic Microspheres (2007)

The first use of magnetic nanoparticles (MNPs) as assembling components in complex coacervation is presented. The single-step formation of MNP-based microspheres (see figure) can be considered as a NP self-assembly process induced by the presence of polyelectrolytes, in which solid microspheres are rapidly generated at ambient temperature, without the need for a solid template.
ROLE OF THE THYMUS IN TRANSPLANTATION TOLERANCE IN MINIATURE SWINE (1999)

A partial thymectomy or serial thymic biopsies markedly interfere with the induction of tolerance to renal allografts. Serial thymic incisions also interfere with the induction of tolerance, but to a lesser degree. These studies may have implications for tolerance-inducing protocols that involve thymic manipulation.
In vitro amplification of T cell gamma gene rearrangements: a new tool for the assessment of minimal residual disease in acute lymphoblastic leukemias. (1989)

In order to improve the level of sensitivity and specificity of detection of bone marrow minimal residual disease in the acute lymphoid leukemias, we have performed amplification by the polymerase chain reaction of T cell receptor gamma chain gene rearrangements. Cloning and sequencing of amplified leukemic DNA allowed the construction of a clone-specific anti-junctional oligonucleotide to be used for subsequent detection of minimal infiltration by this clone. Using such an oligonucleotide, it was possible to distinguish clonal DNA from polyclonal T lymphocytes and to detect infiltration by this clone at 10(-6) dilution into germline DNA. We therefore describe a generally applicable method for the detection of minimal residual disease in both T-ALL and the majority of B lineage ALLs.
Tetrahedral mesh generation from volumetric binary and grayscale images (2009)

We report a general purpose mesh generator for creating finite-element surface or volumetric mesh from 31) binary or gray-scale medical images. This toolbox incorporates a number of existing free mesh processing utilities and enables researchers to perform a range of mesh processing tasks for image-based mesh generation, including raw image processing, surface mesh extraction, surface re-sampling, and multi-scale/adaptive tetrahedral mesh generation. We also implemented robust algorithms for meshing open-surfaces and sub-region labeling. Atomic meshing utilities for each processing step can be accessed with simple interfaces, which can be streamlined or executed independently. The toolbox is compatible with Matlab or GNU Octave. We demonstrate the applications of this toolbox for meshing a range of challenging geometries including complex vessel network, human brain and breast.
MicroRNAs isolated from peripheral blood in the first trimester predict spontaneous preterm birth (2020)

To predict spontaneous preterm birth among pregnant women in an African American population using first trimester peripheral blood maternal immune cell microRNA.
Superlinear convergence via mixed generalized quasilinearization method and generalized monotone method (2014)

The method of upper and lower solutions guarantees the interval of existence of nonlinear differential equations with initial conditions. To compute the solution on this interval, we need coupled lower and upper solutions on the interval of existence. We provide both theoretical as well as numerical methods to compute coupled lower and upper solutions by using a superlinear convergence method. Further, we develop monotone sequences which converge uniformly and monotonically, and with superlinear convergence, to the unique solution of the nonlinear problem on this interval. We accelerate the superlinear convergence by means of the Gauss–Seidel method. Numerical examples are developed for the logistic equation. Our method is applicable to more general nonlinear differential equations, including Riccati type differential equations.
SULPHUR COMPOSITE MATERIAL (1975)

A new, high-strength construction material was developed for applications that require corrosion resistance to acid and salt solutions. The material consists of asbestos fibers and silica flour bonded together with plasticized sulphur. The specific properties of the material can be tailored to application requirements by varying proportions of the components and by choice of methods used in curing and forming the material. It has a large number of potential uses as pipe or tile in handling salt and dilute acid solutions where concrete and asbestos-cement materials now fail after relatively short exposures. Some of the applications are as pipe for containing acid mine wastes, acidic sewer products in humid soils, and corrosive liquids; as linings for vats, tanks, and ditches where control of leach and waste waters is essential; and as flooring in industrial operations where salt corrosion is a problem. /Author/
Overcoming the Insolubility of Molybdenum Disulfide Nanoparticles through a High Degree of Sidewall Functionalization Using Polymeric Chelating Ligands (2006)

Bedeckte Wände: Die Koordinationschemie mehrzähniger Liganden ermöglichte die Funktionalisierung der Oberfläche hochgradig inerter MoS2-Nanopartikel. Dabei wurde der vierzähnige Nitrilotriessigsäure-Ligand entweder an einen fluoreszierenden Liganden gekuppelt (zur Detektion) oder an ein reaktives Polymer, das ihn mit den Sulfid- und Oxidoberflächen anorganischer Fulleren-MoS2- bzw. -TiO2-Nanostäbchen verknüpft (siehe Bild).
Determination of ascorbic acid in foodstuffs, pharmaceuticals, and body fluids by liquid chromatography with electrochemical detection (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of ascorbic acid in foodstuffs, pharmaceuticals, and body fluids by liquid chromatography with electrochemical detectionLawrence A. Pachla and Peter T. KissingerCite this: Anal. Chem. 1976, 48, 2, 364–367Publication Date (Print):February 1, 1976Publication History Published online1 May 2002Published inissue 1 February 1976https://pubs.acs.org/doi/10.1021/ac60366a045https://doi.org/10.1021/ac60366a045research-articleACS PublicationsRequest reuse permissionsArticle Views449Altmetric-Citations98LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Activated human protein C prevents thrombin-induced thromboembolism in mice. Evidence that activated protein c reduces intravascular fibrin accumulation through the inhibition of additional thrombin generation. (1998)

Activated protein C (APC) is a potent physiologic anticoagulant with profibrinolytic properties, and has been shown to prevent thrombosis in different experimental models. We investigated the effect of human APC on thrombin-induced thromboembolism in mice, a model of acute intravascular fibrin deposition leading to death within minutes. APC given intravenously (i.v.) as a bolus 2 min before thrombin challenge (1,250 U/kg) reduced mortality in a dose-dependent manner despite the lack of thrombin inhibitor activity. Significant inhibition of thrombin-induced death was observed at the dose of 0.05 mg/kg, and maximal protection was obtained with 2 mg/kg (> 85% reduction in mortality rate). Histology of lung tissue revealed that APC treatment (2 mg/kg) reduced significantly vascular occlusion rate (from 89.2 to 46.6%, P < 0.01). The protective effect of APC was due to the inhibition of endogenous thrombin formation as indicated by the fact that (a) the injection of human thrombin caused a marked decrease in the coagulation factors of the intrinsic and common pathways (but not of Factor VII), suggesting the activation of blood clotting via the contact system; (b) APC pretreatment reduced markedly prothrombin consumption; (c) the lethal effect of thrombin was almost abolished when the animals were made deficient in vitamin K-dependent factors by warfarin treatment, and could be restored only by doubling the dose of thrombin, indicating that the generation of endogenous thrombin contributes significantly to death; and (d) APC failed to protect warfarin-treated animals, in which mortality is entirely due to injected thrombin, even after protein S supplementation. Other results suggest that APC protects from thrombin-induced thromboembolism by rendering the formed fibrin more susceptible to plasmin degradation rather than by reducing fibrin formation: in thrombin-treated mice, fibrinogen consumption was not inhibited by APC; and inhibition of endogenous fibrinolysis by epsilon-aminocaproic or tranexamic acid resulted in a significant reduction of the protective effect of APC. Since APC did not enhance plasma fibrinolytic activity, as assessed by the measurement of plasminogen activator (PA) or PA inhibitor (PAI) activities, PAI-1 antigen, or 125I-fibrin degrading activity, we speculate that the inhibition of additional (endogenous) thrombin formation by APC interrupts thrombin-dependent mechanisms that make fibrin clots more resistant to lysis, so that the intravascular deposited fibrin can be removed more rapidly by the endogenous fibrinolytic system.