gebhart/patrepeval huggingface dataset:
Negative Autoregulation by FAS Mediates Robust Fetal Erythropoiesis (2007)

Tissue development is regulated by signaling networks that control developmental rate and determine ultimate tissue mass. Here we present a novel computational algorithm used to identify regulatory feedback and feedforward interactions between progenitors in developing erythroid tissue. The algorithm makes use of dynamic measurements of red cell progenitors between embryonic days 12 and 15 in the mouse. It selects for intercellular interactions that reproduce the erythroid developmental process and endow it with robustness to external perturbations. This analysis predicts that negative autoregulatory interactions arise between early erythroblasts of similar maturation stage. By studying embryos mutant for the death receptor FAS, or for its ligand, FASL, and by measuring the rate of FAS-mediated apoptosis in vivo, we show that FAS and FASL are pivotal negative regulators of fetal erythropoiesis, in the manner predicted by the computational model. We suggest that apoptosis in erythroid development mediates robust homeostasis regulating the number of red blood cells reaching maturity.
Negative impact on clinical outcome of the mutational co-occurrence of<i>SF3B1</i>and<i>DNMT3A</i>in refractory anemia with ring sideroblasts (RARS) (2016)

The incidence of SF3B1 mutations in patients with RARS is high. Recently, it has been shown that SF3B1 and DNMT3A mutations overlap more often than expected, although it is not clear how this could affect the disease. We studied SF3B1 and DNMT3A in 123 RARS patients: 101 out of 123 samples (82%) had somatic mutations in SF3B1, and 13 of them (13%) showed a co-mutation (SF3B1mutDNMT3Amut). All co-mutated patients had a normal karyotype, and 12 of them (92%) were lower-risk patients (IPSS and IPSS-R). Despite their favorable profile, SF3B1mutDNMT3Amut patients showed a higher RBC transfusion dependency (92% versus 48%, p = .007), a shorter overall survival (OS) (median, 30 versus 97 months, p = .034), and a higher risk of progression to acute myeloid leukemia (AML) at 5 years (25% versus 2%, p = .023) than SF3B1mutDNMT3Awt patients. In conclusion, DNMT3A mutations are present in a significant proportion of SF3B1mut patients with a negative clinical impact.
Third Party Auditing For Secure Data Storage in Cloud through Trusted Third Party Auditor Using RC5 (2014)

Cloud computing is an internet based computing which enables sharing of services. Cloud data security is a major concern for the client while using the cloud services provided by the service provider. There can be some security issues and conflicts between the client and the service provider. To resolve those issues, a third party can be used as an auditor. The main goal of cloud computing concept is to secure; protect the data and the processes which come under the property of users. In this paper, we have ensure reliable data storage using cloud services. It mainly focuses on the way of providing computing resources in form of service rather than a product and utilities are provided to users over internet. In the cloud, application and services move to centralized huge data center and services and management of this data may not be trustworthy, into cloud environment the computing resources are under control of service provider and the third-party-auditor ensures the data integrity over out sourced data. In this paper, we proposed encryption method at TPA side to protect the privacy and integrity of outsourced data in cloud environment. To ensure the correctness of data, we consider the task of allowing a third party auditor (TPA), on behalf of the cloud client, to verify the integrity of the data stored in the cloud., the auditing process should bring in no new vulnerabilities towards user data privacy, and introduce no additional online burden to user. In this paper, we propose a secure cloud storage system supporting privacypreserving public auditing. This shows the proposed scheme is highly efficient. Here Work is focuses on RC5 Encryption Algorithm for stored data in cloud. Resulted encrypted method is secure and easy to use.
ChemInform Abstract: Nucleosides and Oligonucleotides with Diynyl Side Chains: The Huisgen‐Sharpless Cycloaddition “Click Reaction” Performed on DNA and Their Constituents (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Digital pulse-shape analyzer based on fast sampling of an integrated charge pulse (1995)

A novel configuration for pulse-shape analysis and discrimination has been developed. The current pulse from the detector is sent to a gated integrator and then sampled by a flash analog-to-digital converter(ADC). The sampled data are processed digitally, thus allowing implementation of a near-optimum weighting function and elimination some of the instabilities associated with the gated integrator. The analyzer incorporates pileup rejection circuit that reduces the pileup effects at high counting rates. The system was tested using a liquid scintillator. Figures of merit for neutron-gamma pulse-shape discrimination were found to be: 0.78 for 25 keV (electron equivalent energy) and 3.5 for 500 keV.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Multipoint measurements of field‐aligned current density in the auroral zone (2003)

In this paper we present the analysis and interpretation of a multipoint observation of magnetic field structures at the poleward edge of a premidnight auroral arc by the Enstrophy sounding rocket mission. Four Free‐Flying Magnetometers (FFMs) employing autonomous nanospacecraft technology were deployed from the main payload during the flight, and multipoint magnetic field measurements were made. Signatures consistent with both spatial and temporal interpretations were found to be present when large fluctuations in B were seen at the edge of an arc as the rocket flew into the polar cap. Reasons for the interpretation of spatial or temporal features are given and supported by a simple model of multiple payloads crossing through several moving current sheets and a study of the fine structure of this auroral event using multipoint, correlative wavelet analysis to find velocities of structures at different scale sizes. We show that the direct measurement method of current density using multipoint measurement of magnetic fields gives us a different current density than what would be inferred from a single‐point measurement and that the multipoint measurement also provides an inherent check on the validity of the measurement through a calculation of the divergence of the measured B .
Effect of continuous venovenous hemofiltration with dialysis on lactate clearance in critically ill patients (1997)

Continuous venovenous hemofiltration with dialysis cannot mask lactate overproduction, and its blood concentration remains a reliable marker of tissue oxygenation in patients receiving this renal replacement technique.
Development of <i>Galleria mellonella</i> as an Alternative Infection Model for the <i>Burkholderia cepacia</i> Complex (2008)

Burkholderia is an important bacterial genus with a complex taxonomy that contains species of both ecological and pathogenic importance, including nine closely related species collectively termed the Burkholderia cepacia complex (BCC). In order to more thoroughly investigate the virulence of this bacterial complex of microorganisms, alternative infection models would be useful. To this end, we have adapted and developed the use of the Galleria mellonella wax moth larvae as a host for examining BCC infections. The experimental conditions affecting the BCC killing of the "wax worm" were optimized. BCC virulence levels were determined using 50% lethal doses, and differences were observed between both species and strains of the BCC. The BCC pathogenicity trends obtained compare favorably with results acquired using other published alternative infection models, as well as mammalian infection models. In addition, BCC killing activity was determined by directly measuring relative bacterial loads in three different BCC strains, thus demonstrating innate differences in BCC strain virulence. Finally, genetically mutated BCC strains were compared to a wild-type BCC strain in order to show concomitant reduction of BCC virulence and increased wax worm survival. For experimentation examining the virulent properties of the BCC, the wax worm has proven to be a useful alternative infection model.
Predictive Value of Elevated LH/FSH Ratio for Ovulation Induction in Patients with Polycystic Ovary Syndrome. (2016)

LH/FSH ratio ≥ 1 could be useful as a predictive tool to identify which subgroup of PCOS patients may be more successful in forming a dominant follicle when using letrozole as compared to CC.
Effect of improving spatial or temporal resolution on image quality and quantitative perfusion assessment with <i>k‐t</i> SENSE acceleration in first‐pass CMR myocardial perfusion imaging (2010)

k-t Sensitivity-encoded (k-t SENSE) acceleration has been used to improve spatial resolution, temporal resolution, and slice coverage in first-pass cardiac magnetic resonance myocardial perfusion imaging. This study compares the effect of investing the speed-up afforded by k-t SENSE acceleration in spatial or temporal resolution. Ten healthy volunteers underwent adenosine stress myocardial perfusion imaging using four saturation-recovery gradient echo perfusion sequences: a reference sequence accelerated by sensitivity encoding (SENSE), and three k-t SENSE-accelerated sequences with higher spatial resolution ("k-t High"), shorter acquisition window ("k-t Fast"), or a shared increase in both parameters ("k-t Hybrid") relative to the reference. Dark-rim artifacts and image quality were analyzed. Semiquantitative myocardial perfusion reserve index (MPRI) and Fermi-derived quantitative MPR were also calculated. The k-t Hybrid sequence produced highest image quality scores at rest (P = 0.015). Rim artifact thickness and extent were lowest using k-t High and k-t Hybrid sequences (P < 0.001). There were no significant differences in MPRI and MPR values derived by each sequence. Maximizing spatial resolution by k-t SENSE acceleration produces the greatest reduction in dark rim artifact. There is good agreement between k-t SENSE and standard acquisition methods for semiquantitative and fully quantitative myocardial perfusion analysis.
The Beta-Arrestin-Biased Dopamine D2 Receptor Ligand, UNC9994, Is a Partial Agonist at G-Protein-Mediated Potassium Channel Activation (2018)

UNC9994 modulates G protein-coupled inward rectifier potassium channel channel activation via pertussis toxin-sensitive G proteins at dopamine D2 receptor and dopamine D3 receptor. These findings may have implications for the interpretation of data obtained with this ligand.
Sequential filtering for color image acquisition (2014)

We present an alternative method of color imaging. It utilizes a single standard Si-based image sensor and a clear aperture, tunable, color filter. Within this scheme, three monochromatic frames are taken; each is acquired with a single color and with a fraction of the total acquisition duration. This scheme offers several advantages compared to standard Bayer-demosaicing schemes. Among them - significantly higher resolution, flexibility in exposure durations, improved noise performance and in sum - better image quality. This paper presents both color filter design and the adjusted image pipeline. Lastly, the proposed imaging scheme and the Bayer scheme are compared in terms of MSE.
K-1920 Simultaneous Measurement of Vapor and Liquid Phase Concentration Distributions in a D.I. Diesel Spray by Laser Absorption Scattering Technique (2001)

A dual-wavelength laser absorption-scattering (LAS) technique was developed by use of the second harmonic (532nm) and the fourth harmonic (266nm) of a pulsed Nd: YAG laser as incident light and dimethylnaphthalene (DMN) as the test fuel. By applying this technique, imaging was made of DMN sprays injected into a high-temperature and high-pressure constant volume vessel by a single-hole nozzle and a common rail injection system for D.I. Diesel engine. The line-of-sight optical thickness of both fuel vapor and droplets in the sprays was obtained from the sprays images. The quantitative information of the distributions of the vapor concentration and droplets density was further deconvoluted using the onion-peeling model.
RELATIONSHIP OF AGGREGATE VOIDAGE TO GRADATION (1965)

The purpose of intraoperative monitoring of many modalities is to save some structures of the nervous system being at risk of damaging during surgical procedures. In cerebellopontine angle (cpa) tumour cases these nervous system structures can include cranial nerves (trigeminal, facial, cochlear, accessory), motor and sensory tracts localised within brainstem, and other. Continuous registration of somatosensory and auditory evoked potentials as well as electromyography of masseter muscle, orbicular muscle of eye and trapezius muscle during procedure is the method of brainstem, cochlear tract and cranial nerves status evaluation. Direct stimulation of cranial nerves within posterior fossa using bipolar electrode is the method of facial, trigeminal and accessory nerves localisation, especially in patients with large tumours. In Department of Neurosurgery Silesian University School of Medicine for intraoperative monitoring of many modalities in cpa lesion cases Nocolet Viking IV D unit with special IOM software is employed. Authors presented own experience in such method and effect in treatment of group of 15 patients operated with electrophysiological intraoperative monitoring.
Adjacent satellite interference from a network Of MF-TDMA satellite communications on-the-move terminals (2012)

Satellite Communications on-the-move (SOTM) networks are being deployed to provide various broadband communication services. Typically, an SOTM network consists of a large number of small aperture terminals deployed over a wide geographical area. These terminals are intended to operate over geostationary orbit satellites. To utilize network resources efficiently, these networks may employ time- and frequency-division multiple access methods. Also, SOTM terminals may operate using a range of antenna aperture sizes and may require different transmit power levels to meet various user's data rate needs. Additionally, antenna pointing errors of the terminals may contribute to a time-varying interference pattern from the SOTM network to a victim receiver in another satellite network. This paper provides a methodology to analyze the time-varying interference resulting from an MF-TDMA network consisting of such terminals. This methodology has been submitted for consideration by ITU-R Working Party 4A.
A novel form of intercalation involving four DNA duplexes in an acridine-4-carboxamide complex of d(CGTACG)2 (2000)

The structures of the complexes formed between 9-amino-[N:-(2-dimethyl-amino)butyl]acridine-4-carboxamide and d(CG(5Br)UACG)(2) and d(CGTACG)(2) have been solved by X-ray crystallography using MAD phasing methodology and refined to a resolution of 1.6 A. The complexes crystallised in space group C222. An asymmetric unit in the brominated complex comprises two strands of DNA, one disordered drug molecule, two cobalt (II) ions and 19 water molecules (31 in the native complex). Asymmetric units in the native complex also contain a sodium ion. The structures exhibit novel features not previously observed in crystals of DNA/drug complexes. The DNA helices stack in continuous columns with their central 4 bp adopting a B-like motif. However, despite being a palindromic sequence, the terminal GC base pairs engage in quite different interactions. At one end of the duplex there is a CpG dinucleotide overlap modified by ligand intercalation and terminal cytosine exchange between symmetry-related duplexes. A novel intercalation complex is formed involving four DNA duplexes, four ligand molecules and two pairs of base tetrads. The other end of the DNA is frayed with the terminal guanine lying in the minor groove of the next duplex in the column. The structure is stabilised by guanine N7/cobalt (II) coordination. We discuss our findings with respect to the effects of packing forces on DNA crystal structure, and the potential effects of intercalating agents on biochemical processes involving DNA quadruplexes and strand exchanges. NDB accession numbers: DD0032 (brominated) and DD0033 (native).
Arabidopsis SGT1b Is Required for SCF<sup>TIR1</sup>-Mediated Auxin Response (2003)

The SCF(TIR1) complex is a central regulator of the auxin response pathway in Arabidopsis. This complex functions as a ubiquitin protein ligase that targets members of the auxin/indoleacetic acid (Aux/IAA) family of transcriptional regulators for ubiquitin-mediated degradation in response to auxin. In an attempt to identify additional factors required for SCF(TIR1) activity, we conducted a genetic screen to isolate enhancers of the auxin response defect conferred by the tir1-1 mutation. Here, we report the identification and characterization of the eta3 mutant. The eta3 mutation interacts synergistically with tir1-1 to strongly enhance all aspects of the tir1 mutant phenotype, including auxin inhibition of root growth, lateral root development, hypocotyl elongation at high temperature, and apical dominance. We isolated the ETA3 gene using a map-based cloning strategy and determined that ETA3 encodes SGT1b. SGT1b was identified recently as a factor involved in plant disease resistance signaling, and SGT1 from barley and tobacco extracts was shown to interact with SCF ubiquitin ligases. We conclude that ETA3/SGT1b is required for the SCF(TIR1)-mediated degradation of Aux/IAA proteins.
Fabrication of electrically conductive metal oxide coatings by reactive ion plating (1985)

Electrically conductive metal oxide (ceramic) coatings produced by reactive ion plating are being investigated at USA-CERL for potential application in cathodic protection systems. Ceramic materials are advantageous because of their very low dissolution rates (typically less than 1 g/A/yr in 3.5% NaCl solution) and ease of fabrication. Among the ceramic anode materials currently under investigation are two systems: (1) a mixture of titanium oxide and ruthenium oxide and (2) a mixture of titanium oxides ‘‘doped’’ with niobium, each ion plated on niobium substrates. The mixed oxide coatings were fabricated by a reactive ion plating process involving oxygen and dual electron beam evaporation sources. An enhanced plasma was used to increase reactivity. X-ray diffraction, scanning electron microscopy, and energy dispersive x-ray spectroscopy have been used for characterization of the microstructure, crystallography, and elemental composition of the coating.
Melanocortins and their Receptors and Antagonists (2003)

The melanocortins are a group of small protein hormones derived by post-translational cleavage of the proopiomelanocortin (POMC) gene product. The known melanocortin hormones include α-melanocyte stimulating hormone (MSH), β-MSH, γ-MSH and adrenocorticotropic hormone (ACTH). Five melanocortin receptors (MC1R through to MC5R) have been identified and most of these show tissue-specific expression patterns, as well as different binding affinities for each of the melanocortin hormones. The central melanocortin system consists of α-MSH, agouti-related protein (AGRP), MC3R and MC4R. AGRP and α-MSH are believed to be the natural antagonist and agonist respectively of MC3R and MC4R. This central melanocortin system is thought to play a fundamental role in the control of feeding and body weight. Knock-out mice models and genetic studies have pointed to the importance of the melanocortins in complex human pathways such as pigmentation, lipolysis, food intake, thermogenesis, sexual behaviour, memory and inflammatory response. Recently the melanocortins and their receptors have been the target for drug-based treatment of human physiological processes. MC3R and MC4R are likely targets for controlling body weight; MC1R may be used in the treatment of inflammation and MC2R for the treatment of glucocortical deficiency. A role for MC5R still remains unclear, but the evidence suggests an exocrine gland function. Keywords: Melanocortins, MC3R and MC4R, thermogenesis
Risk of Exposure of Surgical Personnel to Patients' Blood during Surgery at San Francisco General Hospital (1990)

We undertook an observational study of 1307 consecutive surgical procedures at San Francisco General Hospital to record descriptions of intraoperative exposures to blood and other body fluids, determine the factors predictive of these exposures, and identify interventions that might reduce their frequency. During a two-month period, circulating nurses took note of parenteral and cutaneous exposures to blood and recorded information about all procedures. In a follow-up validation study, 50 additional procedures were observed by the study investigators to determine the accuracy of the data collected by the nurses. A total of 960 gloves used by surgical personnel during the validation study were examined to determine the perforation rate. Accidental exposure to blood (parenteral or cutaneous) occurred during 84 procedures (6.4 percent; 95 percent confidence interval, 5.1 to 7.8 percent). Parenteral exposure occurred in 1.7 percent. The risk of exposure was highest when the procedures lasted more than three hours, when blood loss exceeded 300 ml, and when major vascular and intraabdominal gynecologic surgery was involved. Neither knowledge of diagnosed human immunodeficiency virus (HIV) infection nor awareness of a patient's high-risk status for such infection influenced the rate of exposure. Double gloving prevented perforations of the inner glove and cutaneous exposures of the hand. We conclude that all surgical personnel are at risk for intraoperative exposure to blood. Our data support the practice of double gloving and the increased use of water-proof garments and face shields to prevent mucocutaneous exposures to blood. No evidence was found to suggest that preoperative testing for HIV infection would reduce the frequency of accidental exposures to blood.
Investigation of a visual telephone prototyping on personal computers (1996)

An investigation of a visual telephone prototyping is presented. All the related standards such as system requirements, video codec, and speech codec are introduced. Since the most time-consuming task is video encoding, more details about the H.263 video codec standard are explained. In addition, the strategies for real-time transmission and processing are discussed. From the simulation results, the suggested prototype on personal computers shows the potential on multimedia communication for consumer products.