gebhart/patrepeval huggingface dataset:
Biomimetic Polysaccharide Nanocomposites of High Cellulose Content and High Toughness (2007)

Plant cell walls combine mechanical stiffness, strength and toughness despite a highly hydrated state. Inspired by this, a nanostructured cellulose network is combined with an almost viscous polysaccharide matrix in the form of a 50/50 amylopectin-glycerol blend. Homogeneous films with a microfibrillated cellulose (MFC) nanofiber content in the range of 10-70 wt % are successfully cast. Characterization is carried out by dynamic mechanical analysis, field-emission scanning electron microscopy, X-ray diffraction, and mercury density measurements. The MFC is well dispersed and predominantly oriented random-in-the-plane. High tensile strength is combined with high modulus and very high work of fracture in the nanocomposite with 70 wt % MFC. The reasons for this interesting combination of properties include nanofiber and matrix properties, favorable nanofiber-matrix interaction, good dispersion, and the ability of the MFC network to maintain its integrity to a strain of at least 8%.
Reversal of acute and chronic synovial inflammation by anti-transforming growth factor beta. (1993)

Transforming growth factor beta (TGF-beta) induces leukocyte recruitment and activation, events central to an inflammatory response. In this study, we demonstrate that antagonism of TGF-beta with a neutralizing antibody not only blocks inflammatory cell accumulation, but also tissue pathology in an experimental model of chronic erosive polyarthritis. Intraarticular injection of monoclonal antibody 1D11.16, which inhibits both TGF-beta 1 and TGF-beta 2 bioactivity, into animals receiving an arthropathic dose of bacterial cell walls significantly inhibits arthritis. Inhibition was observed with a single injection of 50 micrograms antibody, and a 1-mg injection blocked acute inflammation > 75% compared with the contralateral joints injected with an irrelevant isotype control antibody (MOPC21) as quantitated by an articular index (AI = 0.93 +/- 0.23 for 1D11.16, and AI = 4.0 +/- 0 on day 4; p < 0.001). Moreover, suppression of the acute arthritis achieved with a single injection of antibody was sustained into the chronic, destructive phase of the disease (on day 18, AI = 0.93 +/- 0.07 vs. AI = 2.6 +/- 0.5; p < 0.01). The decreased inflammatory index associated with anti-TGF-beta treatment was consistent with histopathologic and radiologic evidence of a therapeutic response. These data implicate TGF-beta as a profound agonist not only in the early events responsible for synovial inflammation, but also in the chronicity of streptococcal cell wall fragment-induced inflammation culminating in destructive pathology. Interrupting the cycle of leukocyte recruitment and activation with TGF-beta antagonists may provide a mechanism for resolution of chronic destructive lesions.
Sexual Conflict via Maternal-Effect Genes in ZW Species (2006)

In female heterogamous (ZW) species, sex-linked genes coding for maternal products that are packaged into the egg open a unique arena for genetic conflict that does not occur in male heterogamous (XY) species. Z-linked maternal-effect alleles that help sons and harm daughters are expected to go to fixation, as are W-linked alleles that help daughters and harm sons. This conflict differs from known cases of meiotic drive, because sex-specific ontogeny, physiology, and gene expression greatly simplify the genetic interactions that lead to sexual conflict. Selection on maternal-effect genes may substantially alter the evolution of ZW compared with XY systems.
Studies on pyrrolidones. Synthesis and <i>N</i>‐alkylation of β‐enaminoesters derived from pyroglutamic acid (1992)

Abstract The condensation of iminoether 7 , derived from pyroglutamic acid (4) , with active methylene reagents such as Meldrum's acid or methyl cyanoacetate, lead to β‐enaminoesters 2 . Solid‐liquid phase transfer N ‐alkylation of these compounds is described.
Interpretational overhead in system software (2021)

Interpreting a program carries a runtime penalty: the interpretational overhead. Traditionally, a compiler removes interpretational overhead by sacrificing inessential details of program execution. However, a broad class of system software is based on non-standard interpretation of machine code or a higher-level language. For example, virtual machine monitors emulate privileged instructions; program instrumentation is used to build dynamic call graphs by intercepting function calls and returns; and dynamic software updating technology allows program code to be altered at runtime. Many of these frameworks are performance-sensitive and several efficiency requirements—both formal and informal—have been put forward over the last four decades. Largely independently, the concept of interpretational overhead received much attention in the partial evaluation (“program specialization”) literature. This dissertation contributes a unifying understanding of efficiency and interpretational overhead in system software. Starting from the observation that a virtual machine monitor is a self-interpreter for machine code, our first contribution is to reconcile the definition of efficient virtualization due to Popek and Goldberg with Jones optimality, a measure of the strength of program specializers. We also present a rational reconstruction of hardware virtualization support (“trap-and-emulate”) from context-threaded interpretation, a technique for implementing fast interpreters due to Berndl et al. As a form of augmented execution, virtualization shares many similarities with program instrumentation. Although several low-overhead instrumentation frameworks are available on today’s hardware, there has been no formal understanding of what it means for instrumentation to be efficient. Our second contribution is a definition of efficiency for program instrumentation in the spirit of Popek and Goldberg’s work. Instrumentation also incurs an implicit overhead because instrumentation code needs access to intermediate execution states and this is antagonistic to optimization. The third contribution is to use partial equivalence relations (PERs) to express the dependence of instrumentation on execution state, enabling an instrumentation/optimization trade-off. Since program instrumentation, applied at runtime, constitutes a kind of dynamic software update, we can similarly restrict allowable future updates to be consistent with existing optimizations. Finally, treating “old” and “new” code in a dynamically-updatable program as being written in different languages permits a semantic explanation of a safety rule that was originally introduced as a syntactic check.
Essential Role for IL-10 in Resistance to Lipopolysaccharide-Induced Preterm Labor in Mice (2006)

IL-10 is highly expressed in the uterus and placenta and is implicated in controlling inflammation-induced pathologies of pregnancy. To investigate the role of IL-10 in regulating preterm labor, the response of IL-10 null mutant mice to low-dose LPS in late gestation was evaluated. When IL-10 null mutant C57BL/6 (IL-10(-/-)) and control (IL-10(+/+)) mice were administered LPS on day 17 of pregnancy, the dose of LPS required to elicit 50% preterm fetal loss was 10-fold lower in IL-10(-/-) mice than in IL-10(+/+) mice. Surviving fetuses in IL-10(-/-) mice exhibited fetal growth restriction at lower doses of LPS than IL-10(+/+) mice. Marked elevation of LPS-induced immunoactive TNF-alpha and IL-6 was evident in the serum, uterus, and placenta of IL-10(-/-) mice, and TNF-alpha and IL-6 mRNA expression was elevated in the uterus and placenta, but not the fetus. Serum IL-1alpha, IFN-gamma, and IL-12p40 were increased and soluble TNFRII was diminished in the absence of IL-10, with these changes also reflected in the gestational tissues. Administration of rIL-10 to IL-10(-/-) mice attenuated proinflammatory cytokine synthesis and alleviated their increased susceptibility to preterm loss. Exogenous IL-10 also protected IL-10(+/+) mice from fetal loss. These data show that IL-10 modulates resistance to inflammatory stimuli by down-regulating proinflammatory cytokines in the uterus and placenta. Abundance of endogenous IL-10 in gestational tissues is therefore identified as a critical determinant of resistance to preterm labor, and IL-10 may provide a useful therapeutic agent in this common condition.
Tumor cyclooxygenase 2-dependent suppression of dendritic cell function. (2003)

Dendritic cells (DCs) serve as professional antigen-presenting cells and are pivotal in the host immune response to tumor antigens. To define the pathways limiting DC function in the tumor microenvironment, we assessed the impact of tumor cyclooxygenase (COX)-2 expression on DC activities. Bone marrow-derived DCs were cultured in either tumor supernatant (TSN) or TSN from COX-2-inhibited tumors. After culture, DCs were pulsed with tumor-specific peptides, and their ability to generate antitumor immune responses was assessed following injection into established murine lung cancer. In vitro, DC phenotype, alloreactivity, antigen processing and presentation, and interleukin (IL)-10 and IL-12 secretion were evaluated. DCs cultured in TSN failed to generate antitumor immune responses and caused immunosuppressive effects that correlated with enhanced tumor growth. However, genetic or pharmacological inhibition of tumor COX-2 expression restored DC function and effective antitumor immune responses. Functional analyses indicated that TSN causes a decrement in DC capacity to (a) process and present antigens, (b) induce alloreactivity, and (c) secrete IL-12. Whereas TSN DCs showed a significant reduction in cell surface expression of CD11c, DEC-205, MHC class I antigen, MHC class II antigen, CD80, and CD86 as well as a reduction in the transporter-associated proteins, transporter associated with antigen processing 1 and 2, the changes in phenotype and function were not evident when DCs were cultured in supernatant from COX-2-inhibited tumors. We conclude that inhibition of tumor COX-2 expression or activity can prevent tumor-induced suppression of DC activities.
A Phase-Shifting Method for Improving the Heating Uniformity of Microwave Processing Materials (2016)

Microwave processing of materials has been found to deliver enormous advantages over conventional processing methods in terms of mechanical and physical properties of the materials. However, the non-uniform temperature distribution is the key problem of microwave processing, which is related to the structure of the cavity, and the placement and physical parameters of the material. In this paper, a new microwave cavity structure with a sliding short based on phase-shifting heating is creatively proposed to improve the temperature uniformity. An electronic mathematical model based on the Finite Element Method (FEM) is built to predict the temperature distribution. Meanwhile, a new computational approach based on the theory of transformation optics is first provided to solve the problem of the moving boundary in the model simulation. At first, the experiment is carried out to validate the model, and heating results from the experiment show good agreement with the model's prediction. Based on the verified model, materials selected among a wide range of dielectric constants are treated by stationary heating and phase-shifting heating. The coefficient of variation (COV) of the temperature and temperature difference has been compared in detail between stationary heating and phase-shifting heating. A significant improvement in heating uniformity can be seen from the temperature distribution for most of the materials. Furthermore, three other materials are also treated at high temperature and the heating uniformity is also improved. Briefly, the strategy of phase-shifting heating plays a significant role in solve the problem of non-uniform heating in microwave-based material processing. A 25%-58% increase in uniformity from adapting the phase-shifting method can be observed for the microwave-processed materials.
A simple and smart telemedicine device for developing regions: a pocket-sized colorimetric reader (2010)

We have proposed a novel mobile healthcare platform, combining a pocket-sized colorimetric reader (13.5 × 6.5 × 2.5 cm(3)) and commercially available 10-parameter urinalysis paper strips (glucose, protein, glucose, bilirubin, urobilinogen, ketones, nitrite, pH, specific gravity, erythrocytes, and leukocytes), capable of sending data with a smart phone. The reader includes a novel colorimetric multi-detection module, which consists of three-chromatic light-emitting diodes, silicon photodiodes and a novel poly(methylmethacrylate) (PMMA) optical splitter. We employed data reading methods using conversions of the signal data (red, blue, and green) to the hue (H) color map or the Y model data, and used a curve-fitting method for the quantification. The reader is battery-powered, inexpensive, light-weight, and very speedy in analysis. And, it was applied to detection of a thousand of human urine samples and demonstrated reliable quantification of urinary glucose and protein. The features can be used by unskilled people on-site to transfer the analyzed data to experts off-site.
Development, testing, and environmental impact assessment of glow‐in‐the‐dark concrete (2019)

Abstract Glow‐in‐the‐dark (GiD) material has the advantage that it can absorb energy in the presence of a light source and emit the absorbed energy in the form of visible light in the absence of external light. The presented research work deals with the development, testing, and environmental impact assessment of GiD‐concrete. New innovative interlocking concrete blocks have been developed which have the ability to GiD without the need of any external power source. The presented GiD‐concrete has the advantage of long‐term durability over using GiD material as emulation. Through experimentation, 20% GiD addition was found to be the optimum dosage for GiD‐concrete. Mechanical tests consisting of strength, skid resistance, thermal cycling, and glow intensity and duration were conducted on the prepared prototypes. In addition, environmental impact assessment and toxicity testing was conducted in accordance with the U.S. Environmental Protection Agency's (U.S. EPA) standards and regulations in order to ascertain the effects of GiD material on the environment and human health. Through these experimentations, the durability and safety of the developed material with regard to the real‐world application have been judged. The provided information can be used by engineers and researchers along with regulatory bodies to develop guidelines regarding the application of the newly developed material in infrastructure projects. Furthermore, the developed prototype can be used in a variety of ways to improve safety and living conditions, ranging from bicycle lanes, pedestrian crossings, building basements, walkways, concrete barriers, and curbstones along with other architectural and esthetical applications.
Smart Drug Delivery System (2016)

This contribution book collects reviews and original articles from eminent experts working in the interdisciplinary arena of novel drug delivery systems and their uses. From their direct and recent experience, the readers can achieve a wide vision on the new and ongoing potentialities of different smart drug delivery systems. Since the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. On the other hand, this reference discusses advances in the design, optimization, and adaptation of gene delivery systems for the treatment of cancer, cardiovascular, diabetic, genetic, and infectious diseases, and considers assessment and review procedures involved in the development of gene-based pharmaceuticals.
Prognostic significance of circulating matrix metalloproteinase-2 to tissue inhibitor of metalloproteinases-2 ratio in recurrence of urothelial cancer after complete resection. (1996)

The relationship between the serum matrix metalloproteinase-2 (MMP-2):tissue inhibitor of metalloproteinases-2 (TIMP-2) ratio and disease recurrence was examined in 53 urothelial cancer patients with muscular invasion or with lymph node metastasis who underwent complete resection. The mean MMP-2:TIMP-2 ratio in 31 patients with recurrence was significantly higher than that in 22 patients without recurrence (P < 0.05). Disease-free survival of patients with high MMP-2:TIMP-2 ratios was extremely poor compared with that of patients with lower ratios (P < 0.01). Cox's multivariate analysis suggests that the serum MMP-2:TIMP-2 ratio would be a new independent prognostic indicator of urothelial cancer recurrence.
Transcriptional regulation of the gluB promoter during plant response to infection. (2004)

Several studies suggest that plant hydrolytic enzymes, such as 1,3-beta-glucanases, may be components of a general defense system against pathogen invasion in several different plant species. We isolated and characterized a genomic sequence coding for a new acidic 1,3-beta-glucanase (gluB) from Solanum tuberosum. The 5' flanking region of the gluB gene was also characterized. A chimeric gene composed of 2998 bp of the promoter sequence from the gluB gene was fused to the beta-glucuronidase (GUS) coding region and used to transform potato and tobacco plants. Transcriptional activation of the gluB promoter was investigated in response to inoculation with Phytophthora infestans (Pi) or tobacco mosaic virus (TMV). In pathogen inoculated transgenic plants, GUS activity was strongly induced locally around necrotic lesions.
Interlayer magnetic coupling: Effect of alloying in the spacer (1996)

The influence of alloying in the spacer on the periods and the amplitudes of the oscillations of exchange coupling in magnetic multilayers is studied from first principles. The effect of substitutional randomness in the spacer is treated within the coherent potential approximation and the validity of the simplified virtual-crystal approximation is examined. As a case study, results obtained for Co(001) slabs in random fcc ${\mathrm{Cu}}_{1\ensuremath{-}x}{M}_{x}$ spacers ($M=\mathrm{N}\mathrm{i},\phantom{\rule{0ex}{0ex}}\mathrm{Z}\mathrm{n},\phantom{\rule{0ex}{0ex}}\mathrm{a}\mathrm{n}\mathrm{d}\phantom{\rule{0ex}{0ex}}\mathrm{A}\mathrm{u}$) are presented and discussed.
200-Mb/s/ch 100-m optical subsystem interconnections using 8-channel 1.3-μm laser diode arrays and single-mode fiber arrays (1994)

Synchronous parallel optical-fiber transmission is an attractive method for providing increased interconnection throughput and higher density in advanced information systems. Skew suppression (reducing transmission delay time variation), error-free fully DC-coupled data transmission capability, compactness, and low power consumption of modules are important requirements. In order to meet these requirements, we developed optical subsystem interconnections using long-wavelength laser diode arrays and single-mode fiber arrays. The major design criteria are discussed, especially as they are related to skew due to laser diode turn-on delay and receiver input optical power variation. The use of low-threshold-current laser diode arrays is an important design requirement. Based on the design criteria discussed in this work, we demonstrated and channel 200-Mb/s/ch 100-m transmission using compact (0.18 cc/ch/module), low power (total 280 mW/ch), fully integrated transmitter and receiver modules with an ECL (emitter coupled logic) interface. These modules include our new laser diode arrays with low threshold current of 3.2 mA. Performance results showed that these modules are very effective as interconnections between synchronously operating subsystems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Broad-band continuous-wave-pumped fiber optical parametric amplifier with 49-dB gain and wavelength-conversion efficiency (2001)

A broad-band continuous-wave (CW) pumped fiber-based parametric amplifier with 39 dB of internal gain and wavelength conversion efficiency, corresponding to a black box gain/efficiency of 38 dB, is demonstrated. Bit-error-rate (BER) measurements indicate performance comparable to erbium-doped fiber amplifiers (EDFAs). These amplifiers may thus find new applications in future lightwave systems.
Miniaturized multi-band filter banks for Extravehicular radio (EVA) Applications (2008)

NASA seeks to employ micro-electromechanical system (MEMS) S-band filters to reduce the size, weight, and power of its reconfigurable, fault-tolerant, next-generation extravehicular activity (EVA) radio. Of particular interest to NASA are banks of channel-select filters from 2.4 - 2.483 GHz. We describe a novel double-layer contour-mode piezoelectric aluminum nitride (AlN) resonator topology that is amenable for use in GHz filter banks. Measured results of a 1.7 GHz resonator are presented, showing a motional resistance of 60 Omega and an electromechanical coupling coefficient of 0.9%. Excellent agreement with a lumped parameter model of the device is observed. Ongoing simulation and design efforts of 2.4 GHz filters employing the novel AlN resonator topology are also reviewed.
Quest for Anionic MOF Membranes: Continuous <b>sod</b>-ZMOF Membrane with CO<sub>2</sub> Adsorption-Driven Selectivity (2015)

We report the fabrication of the first continuous zeolite-like metal-organic framework (ZMOF) thin-film membrane. A pure phase sod-ZMOF, sodalite topology, membrane was grown and supported on a porous alumina substrate using a solvothermal crystallization method. The absence of pinhole defects in the film was confirmed and supported by the occurrence of quantifiable time-lags, for all studied gases, during constant volume/variable pressure permeation tests. For both pure and mixed gas feeds, the sod-ZMOF-1 membrane exhibits favorable permeation selectivity toward carbon dioxide over relevant industrial gases such as H2, N2, and CH4, and it is mainly governed by favorable CO2 adsorption.
Cbfβ-SMMHC impairs differentiation of common lymphoid progenitors and reveals an essential role for RUNX in early B-cell development (2007)

The core-binding factor (CBF)-associated leukemia fusion protein CBFbeta-SMMHC impairs myeloid and lymphoid differentiation. By inhibiting RUNX function, the fusion oncoprotein predisposes specifically to acute myeloid leukemia in both patients and mouse models. We have shown that Cbfbeta-SMMHC expression leads to a sustained reduction of circulating B lymphocytes in the mouse. In this study, we demonstrate that the activation of Cbfbeta-SMMHC reduces pre-pro-B cells approximately 3-fold and pre-B cells more than 10-fold and that this differentiation block is cell-autonomous. The reduction of pre-pro-B cells coincided with an increase in apoptosis in this population. The number of common lymphoid progenitors (CLPs) were not affected; however, the expression of critical early B-cell factors Ebf1, Tcfe2a, and Pax5 was significantly reduced. In addition, Cbfbeta-SMMHC reduced Rag1 and Rag2 expression and impaired V(D)J recombination in the CLPs. Furthermore, CLPs expressing Cbfbeta-SMMHC also show inhibition of B cell-specific genes Cd79a, Igll1, VpreB1, and Blk. These results demonstrate that CBF/RUNX function is essential for the function of CLPs, the survival of pre-pro-B cells, and the establishment of a B lineage-specific transcriptional program. This study also provides a mechanistic basis for the myeloid-lineage bias of CBFbeta-SMMHC-associated leukemia.