gebhart/patrepeval huggingface dataset:
The emerging impact of phage display technology in thrombosis and haemostasis. (1998)

The phage display technology represents a powerful tool for protein and drug design because vast numbers of amino acid sequences can be rapidly explored. This review describes the origins of phage libraries, their evolution and more recent advances, including examples in the area of thrombosis and haemostasis, where the phage display approach has just begun to be used with great success....
Shipboard applications of non-intrusive load monitoring (2004)

The Non-Intrusive Load Monitor (NILM) provides a method of measuring component performance and source power quality through a single point of entry in the power distribution system. A study was performed utilizing the NILM onboard three different ships (along with experimentation in the laboratory) to determine its effectiveness in determining the state of mechanical systems through analysis of electrical power data. Data collected from the Auxiliary Seawater System onboard the USCGC SENECA indicate that the NILM is able to predict several faults (clogged pump inlet strainers, faulty motor/pump coupling, fouled heat exchangers) as well as provide a backup indication of flow levels to heat loads. Data collected from the Sewage System of the SENECA indicate several metrics which can be applied to cycling systems in general to differentiate between periods of heavy usage and fault conditions. Finally, data collected from the Steering System of the SENECA as well as a yard patrol boat operated by the Office of Naval Research shows the potential of the NILM to be used as a control system without the need for separate mechanical transducers.
Design and characterization of a dynamic vibrational culture system (2011)

To engineer a functional vocal fold tissue, the mechanical environment of the native tissue needs to be emulated in vitro. We have created a dynamic culture system capable of generating vibratory stimulations at human phonation frequencies. The novel device is composed of a function generator, a power amplifier, an enclosed loudspeaker and a circumferentially-anchored silicone membrane. The vibration signals are translated to the membrane aerodynamically by the oscillating air pressure underneath. The vibration profiles detected on the membrane were symmetrical relative to the centre of the membrane as well as the resting position over the range of frequencies (60-300 Hz) and amplitudes tested (1-30 µm). The oscillatory motion of the membrane gave rise to two orthogonal, in-plane strain components that are similar in magnitude (0.47%) and are strong functions of membrane thickness. Neonatal foreskin fibroblasts (NFFs) attached to the membrane were subjected to a 1 h vibration at 60, 110 and 300 Hz, with the displacement at the centre of the membrane varying in the range 1-30 µm, followed by a 6 h rest. These regimens did not cause morphological changes to the cells. An increase in cell proliferation was detected when NFFs were driven into oscillation at 110 Hz with a normal displacement of 30 µm. qPCR results showed that the expression of genes encoding some extracellular matrix proteins was altered in response to changes in vibratory frequency and amplitude. The dynamic culture device provides a potentially useful in vitro platform for evaluating cellular responses to vibration.
Performance Study of a Multicast Protocol for Wireless Sensor Networks based on N 2 Connectivity (2007)

We propose a distributed wireless multicast protocol based on 2-hop neighbor information. A unique feature of our algorithm is that the formation of the multicast tree is done during the media access stage and requires little additional message exchanging. Each node only needs to keep track the receiving status for all nodes within its 2-hop neighborhood, leading to a very light protocol. The effectiveness of our approach also comes from a novel MAC layer solution which can quickly resolve the multicast CTS collisions. We conducted detailed simulations to evaluate the performance of the proposed protocol. Simulation results indicate that our protocol offers considerable improvement in multicast turnaround time and has superior energy/packet performance.
Calreticulin reveals a critical Ca2+ checkpoint in cardiac myofibrillogenesis (2002)

Calreticulin (crt) is an ubiquitously expressed and multifunctional Ca(2+)-binding protein that regulates diverse vital cell functions, including Ca(2+) storage in the ER and protein folding. Calreticulin deficiency in mice is lethal in utero due to defects in heart development and function. Herein, we used crt(-/-) embryonic stem (ES) cells differentiated in vitro into cardiac cells to investigate the molecular mechanisms underlying heart failure of knockout embryos. After 8 d of differentiation, beating areas were prominent in ES-derived wild-type (wt) embryoid bodies (EBs), but not in ES-derived crt(-/-) EBs, despite normal expression levels of cardiac transcription factors. Crt(-/-) EBs exhibited a severe decrease in expression and a lack of phosphorylation of ventricular myosin light chain 2 (MLC2v), resulting in an impaired organization of myofibrils. Crt(-/-) phenotype could be recreated in wt cells by chelating extracellular or cytoplasmic Ca(2+) with EGTA or BAPTA, or by inhibiting Ca(2+)/calmodulin-dependent kinases (CaMKs). An imposed ionomycin-triggered cystolic-free Ca(2+) concentration ([Ca(2+)](c)) elevation restored the expression, phosphorylation, and insertion of MLC2v into sarcomeric structures and in turn the myofibrillogenesis. The transcription factor myocyte enhancer factor C2 failed to accumulate into nuclei of crt(-/-) cardiac cells in the absence of ionomycin-triggered [Ca(2+)](c) increase. We conclude that the absence of calreticulin interferes with myofibril formation. Most importantly, calreticulin deficiency revealed the importance of a Ca(2+)-dependent checkpoint critical for early events during cardiac myofibrillogenesis.
Power system event location analysis using wide-area measurements (2006)

Power system frequency can tell volumes about the health and state of a power system. Moreover, the manner in which angle and frequency perturbations travel throughout the power grid has been closely studied in the past. Such perturbations are known to propagate throughout the grid as a function of time and space. Using measurements from a wide-area frequency monitoring network (FNET), one can observe the electromechanical wave signature of power system events in frequency data. In this paper, a brief synopsis of FNET is presented along with an analysis of several generator tripping events. The analysis is comprised of several event location methods and resulting observations. The eventual goal of this research is to formulate a robust event location algorithm that can be used online and in real-time to locate with sufficient accuracy the hypocenter of power system events irrespective of utility boundaries.
Cyclodextrin Membranes: Cyclodextrin Films with Fast Solvent Transport and Shape‐Selective Permeability (Adv. Mater. 26/2017) (2017)

Klaus-Viktor Peinemann and co-workers crosslink cyclodextrins at a water/hexane interface to form continuous films out of these container-shaped molecules. The scalable strategy is described in article number 1606641. The transport of molecules through the resulting flexible thin-films is fast and shape-sensitive thanks to the abundance of defined cavities within them.
Optical Properties of Indium (1973)

Experimental measurements consisting of ellipsometry (0.5-3.5 eV) and normal-incidence reflectance (3.0-11.6 eV) are used along with published data to determine the optical constants of indium from 0.5 to 15.5 eV. Although the over-all properties reflect free-electron behavior, departures from Drude theory can be understood in terms of interband transitions.
Enhanced Third Harmonic Generation in Single Germanium Nanodisks Excited at the Anapole Mode (2016)

We present an all-dielectric germanium nanosystem exhibiting a strong third order nonlinear response and efficient third harmonic generation in the optical regime. A thin germanium nanodisk shows a pronounced valley in its scattering cross section at the dark anapole mode, while the electric field energy inside the disk is maximized due to high confinement within the dielectric. We investigate the dependence of the third harmonic signal on disk size and pump wavelength to reveal the nature of the anapole mode. Each germanium nanodisk generates a high effective third order susceptibility of χ(3) = 4.3 × 10–9 esu, corresponding to an associated third harmonic conversion efficiency of 0.0001% at an excitation wavelength of 1650 nm, which is 4 orders of magnitude greater than the case of an unstructured germanium reference film. Furthermore, the nonlinear conversion via the anapole mode outperforms that via the radiative dipolar resonances by about 1 order of magnitude, which is consistent with our numerical simulations. These findings open new possibilities for the optimization of upconversion processes on the nanoscale through the appropriate engineering of suitable dielectric materials.
An Active Pulse Transmission Line Simulating Nerve Axon (1962)

To electronically simulate an animal nerve axon, the authors made an active pulse transmission line using tunnel diodes. The equation of propagation for this line is the same as that for a simplified model of nerve membrane treated elsewhere. This line shapes the signal waveform during transmission, that is, there being a specific pulse-like waveform peculiar to this line, smaller signals are amplified, larger ones are attenuated, narrower ones are widened and those which are wider are shrunk, all approaching the above-mentioned specific waveform. In addition, this line has a certain threshold value in respect to the signal height, and signals smaller than the threshold or noise are eliminated in the course of transmission. Because of the above-mentioned shaping action and the existence of a threshold, this line makes possible highly reliable pulse transmission, and will be useful for various kinds of information-processing systems.
Fibril Breaking Accelerates α-Synuclein Fibrillization (2015)

The formation of amyloid fibrils of α-synuclein (αSyn), the key protein in Parkinson's disease, is an autocatalytic process that is seeded by mature αSyn fibrils. Based on systematic measurements of the dependence of the fibril growth rate on the concentrations of monomers and preformed fibrillar seeds, we propose a mechanism of αSyn aggregation that includes monomer binding to fibril ends and secondary nucleation by fibril breaking. The model explains the increase of the αSyn aggregation rate under shaking conditions and the exponential increase in the fraction of fibrillar protein at the initial stages of αSyn aggregation. The proposed autocatalytic mechanism also accounts for the high variability in the aggregation lag time. The rate constant of monomer binding to the ends of fibrils, k+ ≈ 1.3 mM(-1) s(-1), was estimated from the aggregation rate and previously reported average fibril lengths. From the aggregation rates at low concentrations the binding of monomeric αSyn to fibrils was found to be almost irreversible, with an equilibrium dissociation constant (Kd) smaller than 3 μM.
Ortho-Planar Mechanisms for Microelectromechanical Systems (2005)

A method for representing the design space of ortho-planar mechanisms has been developed. The method is based on the Theorem of Equality of Orientation Set Measures (TEOSM) which allows mechanisms to be represented by points in an abstract space. The method is first developed for single loop planar folded mechanisms with revolute joints, and later extended to mechanisms with prismatic joints and to spherical folded mechanisms. Functions which assign a value to each point in design space can be used to describe classes of mechanisms and evaluate their utility for MEMS design. Additionally, this work introduces the use of spherical mechanisms in MEMS design. Spherical mechanisms have characteristics that may be useful in MEMS, including the capability of spatial positioning of a link and the ability to convert rotation about an axis perpendicular to the substrate to rotation about an axis parallel to the substrate. Spherical kinematics has been used to develop three novel mechanisms, the Micro Helico-Kinematic Platform (MHKP), the Spherical Bistable Mechanism (SBM), and the Three-degree-of-freedom Platform (3DOFP). Mathematical models of these devices have been developed and MEMS prototypes have been designed and fabricated.
Red blood cell targeting to collagen‐coated surfaces (1983)

The interaction of human red blood cells carrying antihuman collagen antibody with collagen-coated surfaces was studied. Avidin was used as bifunctional crosslinking agent for the attachment of antibody to the red blood cell surface. Antibody-carrying red blood cells efficiently and specifically bound to collagen-coated surface covering a significant part of the surface. The components of normal blood had an insignificant effect on red blood cell binding. A model of drug targeting to the injured sites(s) of blood vessel wall is proposed.
An Emerging Role for Endothelial Nitric Oxide Synthase in Chronic Inflammation and Cancer (2007)

Nitric oxide (NO) is a free radical that is involved in carcinogenesis. Recent literature indicates that endothelial NO synthase (eNOS) can modulate cancer-related events (angiogenesis, apoptosis, cell cycle, invasion, and metastasis). We review the literature linking eNOS to carcinogenesis to encourage future research assessing the role of eNOS in cancer prevention and treatment.
Atrial Natriuretic Peptide and Atrial Pressure in Patients with Congestive Heart Failure (1987)

RAINE, A.; PHIL, D.; ERNE, P.; BÜRGISSER, E.; MÜLLER, F.; BOLLI, P.; BÜRKART, F.; BÜHLER, F. Author Information
Ventilation for mushroom cultivation: the importance of the needs of mushrooms and of the gas laws (2010)

Ventilation depends on physics, chemistry and especially the biological needs of the organism that is being provided for. The history of ventilation is about...
Synthesis of potential antiradiation agents from 3-substituted 2-oxazolidinones derived from phenol, benzenethiol, and related compounds (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of potential antiradiation agents from 3-substituted 2-oxazolidinones derived from phenol, benzenethiol, and related compoundsRobert Daryl Elliott and Thomas Patrick JohnstonCite this: J. Med. Chem. 1969, 12, 2, 253–257Publication Date (Print):March 1, 1969Publication History Published online1 May 2002Published inissue 1 March 1969https://pubs.acs.org/doi/10.1021/jm00302a012https://doi.org/10.1021/jm00302a012research-articleACS PublicationsRequest reuse permissionsArticle Views88Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Integrated Media Approach to Networked Multimedia Systems (1993)

Applications which require real-time multimedia services[13] face a number of difficult problems in the transmission of multimedia information. Among the most difficult problems are the heterogeneity of end nodes and the heterogeneity of media Quality of Service (QoS) requirements. End nodes typically consist of a computer and number of sensory input and output devices, such as displays, microphones, and cameras. QoS requirements[18] include degrees of reliability, jitter, and delay.\nWe propose an integrated approach to address these problems. Multimedia input data comprise a sensory environment which an application will make available; these data are packaged together into an Integrated Multimedia Message (IMM). From a received IMM, output data are selectively reproduced to create another sensory environment. We propose an IMM format and protocol behaviors for generation, presentation, and synchronization of these messages.\nWhile IMM's are aesthetically pleasing, well-suited to proposed high- speed networks, and ease intramessage synchronization, they are potentially plagued by the need to deliver QoS which meets the worst-case requirements of all of their components[6]. We believe that this problem can be addressed, and are testing that belief experimentally with the U. Penn Experimental Multimedia Conferencing System, which will be embedded in the AURORA Gigabit Testbed.
Introduction to Polymers (1981)

Thoroughly updated, Introduction to Polymers, Third Edition presents the science underpinning the synthesis, characterization and properties of polymers. The material has been completely reorganized and expanded to include important new topics and provide a coherent platform for teaching and learning the fundamental aspects of contemporary polymer
Matching Jobs and Resumes: a Deep Collaborative Filtering Task (2018)

This paper tackles the automatic matching of job seekers and recruiters, based on the logs of a recruitment agency (CVs, job announcements and application clicks). Preliminary experiments reveal that good recommendation performances in collaborative filtering mode (emitting recommendations for a known recruiter using the click history) co-exist with poor performances in cold start mode (emitting recommendations based on the job announcement only). A tentative interpretation for these results is proposed, claiming that job seekers and recruiters $-$ whose mother tongue is French $-$ yet do not speak the same language. As first contribution, this paper shows that the information inferred from their interactions differs from the information contained in the CVs and job announcements. The second contribution is the hybrid system \XX (MAtching JObs and REsumes), where a deep neural net is trained to match the collaborative filtering representation properties. The experimental validation demonstrates \XX merits, with good matching performances in cold start mode.
Towards real-scale business transaction workflow modelling (1997)

While the specification languages of workflow management systems focus on process execution semantics, the successful development of workflows relies on a fuller conceptualisation of business processing including the treatment of time, document transfer, and workflow use and reuse. For this, a wellspring of modelling techniques, paradigms and informal-formal method extensions which address broader enterprise modelling and communication (based on speech-act theory), is available. However, the characterisations — indeed the cognition — of workflows still appears coarse. In this paper, we provide the complementary, empirical insight of a real-scale business transaction workflow. The development of the workflow model follows a set of principles which we believe address workflow modelling suitability. Through the principles, advanced considerations including temporal constraints, message construction and deconstruction together with asynchronous and synchronous modes of messaging, service encapsulation, and complex decision and exception handling are motivated. By illustrating the suitability principles and with it the inherent complexity of business transaction domains, we offer timely insights into workflow specification extension.
Long or redundant leaflet complicating transcatheter mitral valve replacement: Case vignettes that advocate for removal or reduction of the anterior mitral leaflet (2017)

Transcatheter mitral valve replacement (TMVR) procedures can be an alternative to surgical valve replacement for high surgical risk patients with bioprosthetic mitral valves, annuloplasty rings, or severe mitral annular calcification (MAC). TMVR can trigger acute left ventricular outflow tract (LVOT) obstruction from permanent displacement of the native anterior mitral leaflet toward the left ventricular septum, more often among patients undergoing valve-in-ring and valve-in-MAC procedures. Although acute LVOT obstruction is well described in the literature, there are important additional complications of TMVR related to the length and/or redundancy of the anterior mitral valve that have been recognized after mitral valve surgery and have not been previously reported in the setting of TMVR. These additional complications include acute mitral regurgitation secondary to prolapsing native leaflet through the TMVR, frozen TMVR leaflet secondary to overhanging native leaflet and late LVOT obstruction in the neo-LVOT secondary to long native leaflet. Preprocedural planning with imaging (echocardiography and computed tomography) and measurement of anterior mitral leaflet length is critical important in understanding the risk for these complications. As transcatheter mitral valve technology proliferates, interactions with the anterior mitral leaflet after TMVR may be more frequent than initially anticipated. We believe that there is no advantage to an intact anterior leaflet and advocate removal or reduction of the leaflet prior to TMVR. © 2017 Wiley Periodicals, Inc.
Novel Mechanism of Steroid Action in Skin through Glucocorticoid Receptor Monomers (2000)

Glucocorticoids (GCs), important regulators of epidermal growth, differentiation, and homeostasis, are used extensively in the treatment of skin diseases. Using keratin gene expression as a paradigm of epidermal physiology and pathology, we have developed a model system to study the molecular mechanism of GCs action in skin. Here we describe a novel mechanism of suppression of transcription by the glucocorticoid receptor (GR) that represents an example of customizing a device for transcriptional regulation to target a specific group of genes within the target tissue, in our case, epidermis. We have shown that GCs repress the expression of the basal-cell-specific keratins K5 and K14 and disease-associated keratins K6, K16, and K17 but not the differentiation-specific keratins K3 and K10 or the simple epithelium-specific keratins K8, K18, and K19. We have identified the negative recognition elements (nGREs) in all five regulated keratin gene promoters. Detailed footprinting revealed that the function of nGREs is to instruct the GR to bind as four monomers. Furthermore, using cotransfection and antisense technology we have found that, unlike SRC-1 and GRIP-1, which are not involved in the GR complex that suppresses keratin genes, histone acetyltransferase and CBP are. In addition, we have found that GR, independently from GREs, blocks the induction of keratin gene expression by AP1. We conclude that GR suppresses keratin gene expression through two independent mechanisms: directly, through interactions of keratin nGREs with four GR monomers, as well as indirectly, by blocking the AP1 induction of keratin gene expression.