gebhart/patrepeval huggingface dataset:
Lipid Peroxides and Essential Fatty Acids in Patients with Coronary Heart Disease (1994)

Coronary heart disease (CHD) is considered to be more common among Indians than Western populations. In patients confirmed to have CHD, plasma lipid peroxides were found to be high, whereas the n-6 fatty acid gamma-linolenic acid and the metabolites of alpha-linolenic acid (n-3 fatty acid), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), were significantly lower in the plasma phospholipid fraction. EPA and DHA and anti-oxidant vitamin E are believed to have a protective action against CHD. These results suggest that increased formation of lipid peroxides and low plasma levels of EPA and DHA are closely associated with CHD in Indians. If so, this suggests that supplementation of EPA and DHA and anti-oxidants such as vitamin E may be indicated to prevent CHD in Indians.
High-Q fused silica birdbath and hemispherical 3-D resonators made by blow torch molding (2013)

This paper presents a novel 3-D fabrication process of microstructures using high-Q materials. The key feature of this process is the use of a blow torch that can provide intensive localized heat up to 2500°C in a very short time (<;10 sec), above the melting temperatures of many high-Q materials such as fused silica. Surface roughness of 5.3 Å is realized in fused silica, which is crucial for high optical and mechanical quality factors (Q). We demonstrate the fabrication of micro hemisphere and half-toroid (birdbath) geometries from 100μm-thick fused silica substrates. We also create micro birdbath resonators by batch-level releasing the birdbath shells and demonstrate one of the best mechanical Q and low stiffness and damping anisotropies among existing micro mechanical resonators. The birdbath resonator is promising for emerging applications such as micro rate-integrating gyroscope (μ-RIG).
A remote measuring flow meter for petroleum and other industrial applications (1998)

The blown venturi flow meter based on a Coanda switched venturi resistance, has been investigated for use in petroleum and other industrial applications. It produces self-induced oscillations in the fluid at a frequency proportional to the rate of flow and the pressure waves are transmitted via the flowing fluid and detected downstream. Experimental work has been conducted by measuring the attenuation of the waves in air flow along a 28.5 m long, 0.05 m diameter pipe downstream of the flow meter, ensuring that the remote flow metering concept is realized. Predictions of pressure pulse strength, pressure loss and frequency for the flow meter in an oil production string have been made. Potential applications of this meter to nuclear fuel reprocessing and other hostile environments have also been demonstrated. Furthermore, accuracy and limitations of the flow meter for engineering applications are considered.
Locating network monitors: complexity, heuristics, and coverage (2005)

There is increasing interest in concurrent passive monitoring of IP flows at multiple locations within an IP network. The common objective of such a distributed monitoring system is to sample packets belonging to a large fraction of IP flows in a cost-effective manner by carefully placing monitors and controlling their sampling rates. In this paper, we consider the problem of where to place monitors within the network and how to control their sampling. To address the tradeoff between monitoring cost and monitoring coverage, we consider minimum cost and maximum coverage problems under various budget constraints. We show that all of the defined problems are NP-hard. We propose greedy heuristics, and show that the heuristics provide solutions quite close to the optimal solutions through experiments using synthetic and real network topologies. In addition, our experiments show that a small number of monitors is often enough to monitor most of the traffic in an entire IP network.
ATM kinase inhibition in glial cells activates the innate immune response and causes neurodegeneration in <i>Drosophila</i> (2012)

To investigate the mechanistic basis for central nervous system (CNS) neurodegeneration in the disease ataxia-telangiectasia (A-T), we analyzed flies mutant for the causative gene A-T mutated (ATM). ATM encodes a protein kinase that functions to monitor the genomic integrity of cells and control cell cycle, DNA repair, and apoptosis programs. Mutation of the C-terminal amino acid in Drosophila ATM inhibited the kinase activity and caused neuron and glial cell death in the adult brain and a reduction in mobility and longevity. These data indicate that reduced ATM kinase activity is sufficient to cause neurodegeneration in A-T. ATM kinase mutant flies also had elevated expression of innate immune response genes in glial cells. ATM knockdown in glial cells, but not neurons, was sufficient to cause neuron and glial cell death, a reduction in mobility and longevity, and elevated expression of innate immune response genes in glial cells, indicating that a non-cell-autonomous mechanism contributes to neurodegeneration in A-T. Taken together, these data suggest that early-onset CNS neurodegeneration in A-T is similar to late-onset CNS neurodegeneration in diseases such as Alzheimer's in which uncontrolled inflammatory response mediated by glial cells drives neurodegeneration.
Control-Winding Direct Power Control Strategy for Five-Phase Dual-Stator Winding Induction Generator DC Generating System (2019)

A control-winding direct power control (CWDPC) strategy for a dc generating system based on the five-phase dual-stator winding induction generator is proposed and investigated in this article. For this generator, the flux-oriented control is usually employed in the previous work mainly for the sake of good static performance. However, the present control strategy has the limitation of the further enhancement of the dynamic properties. This article explores a CWDPC strategy to upgrade the dynamic performance of this generating system. The fundamental active power of the five-phase control winding (CW) relates to its dc bus voltage while the dc bus voltage on the five-phase power-winding (PW) side is related to the control of five-phase CW fundamental reactive power. By replacing inner current loops to power control loops, the CW instantaneous fundamental active and reactive powers are calculated through the power observer and regulated directly through two power-control loops. In the transient process, the CW fundamental active power changes slightly while the reactive power can be quickly controlled for fast recovery of the dc bus voltage on the five-phase PW side. As the system has an additional control degree of freedom, the third harmonic is also considered in the proposed strategy, and the corresponding implementation is given as well. The simulation and experimental results demonstrate that using the proposed CWDPC strategy, the system has shorter transient time and lower voltage change in the dynamic response than the flux-oriented control strategy, which means the dynamic performance is further improved.
Adaptive Exponential Smoothing for Online Filtering of Pixel Prediction Maps (2015)

We propose an efficient online video filtering method, called adaptive exponential filtering (AES) to refine pixel prediction maps. Assuming each pixel is associated with a discriminative prediction score, the proposed AES applies exponentially decreasing weights over time to smooth the prediction score of each pixel, similar to classic exponential smoothing. However, instead of fixing the spatial pixel location to perform temporal filtering, we trace each pixel in the past frames by finding the optimal path that can bring the maximum exponential smoothing score, thus performing adaptive and non-linear filtering. Thanks to the pixel tracing, AES can better address object movements and avoid over-smoothing. To enable real-time filtering, we propose a linear-complexity dynamic programming scheme that can trace all pixels simultaneously. We apply the proposed filtering method to improve both saliency detection maps and scene parsing maps. The comparisons with average and exponential filtering, as well as state-of-the-art methods, validate that our AES can effectively refine the pixel prediction maps, without using the original video again.
Microarray Identifies Extensive Downregulation of Noncollagen Extracellular Matrix and Profibrotic Growth Factor Genes in Chronic Isolated Mitral Regurgitation in the Dog (2009)

LV collagen loss in isolated, compensated MR is chiefly due to posttranslational processing and degradation. The downregulation of multiple noncollagen genes important in global extracellular matrix structure, coupled with decreased expression of multiple profibrotic factors, explains the failure to replace interstitial collagen in the MR heart.
An exploration of affine group laws for elliptic curves (2011)

Abstract Several forms of elliptic curves are suggested for an efficient implementation of Elliptic Curve Cryptography. However, a complete description of the group law has not appeared in the literature for most popular forms. This paper presents group law in affine coordinates for three forms of elliptic curves. With the existence of the proposed affine group laws, stating the projective group law for each form becomes trivial. This work also describes an automated framework for studying elliptic curve group law, which is applied internally when preparing this work.
Carboxylated, Heteroaryl-Substituted Chalcones as Inhibitors of Vascular Cell Adhesion Molecule-1 Expression for Use in Chronic Inflammatory Diseases (2007)

Starting from a simple chalcone template, structure-activity relationship (SAR) studies led to a series of carboxylated, heteroaryl-substituted chalcone derivatives as novel, potent inhibitors of vascular cell adhesion molecule-1 (VCAM-1) expression. Correlations between lipophilicity determined by calculated logP values and inhibitory efficacy were observed among structurally similar compounds of the series. Various substituents were found to be tolerated at several positions of the chalcone backbone as long as the compounds fell into the right range of lipophilicity. The chalcone alpha,beta-unsaturated ketone moiety seemed to be the pharmacophore required for inhibition of VCAM-1 expression. Compound 19 showed significant antiinflammatory effects in a mouse model of allergic inflammation, indicating that this series of compounds might have therapeutic value for human asthma and other inflammatory disorders.
Low Plasma Adiponectin Levels Predict Progression of Coronary Artery Calcification (2005)

Low plasma adiponectin levels are associated with progression of CAC in type 1 diabetic and nondiabetic subjects independently of other cardiovascular risk factors.
Biofuels and Biomass‐To‐Liquid Fuels in the Biorefinery: Catalytic Conversion of Lignocellulosic Biomass using Porous Materials (2008)

At a time when the focus is on global warming, CO(2) emission, secure energy supply, and less consumption of fossil-based fuels, the use of renewable energy resources is essential. Various biomass resources are discussed that can deliver fuels, chemicals, and energy products. The focus is on the catalytic conversion of biomass from wood. The challenges involved in the processing of lignocellulose-rich materials will be highlighted, along with the application of porous materials as catalysts for the biomass-to-liquids (BTL) fuels in biorefineries. The mechanistic understanding of the complex reactions that take place, the development of catalysts and processes, and the product spectrum that is envisaged will be discussed, along with a sustainable concept for biorefineries based on lignocellulose. Finally, the current situation with respect to upgrading of the process technology (pilot and commercial units) will be addressed.
Is the mouse a good model for the human with respect to the development of the preimplantation embryo in vitro? (1998)

A comparison has been made of various aspects of preimplantation development of mouse and human embryos in vitro. Changes in substrate utilization follow similar patterns in both species. This similarity in metabolic parameters between the two species has facilitated the use of the mouse as a model to study the formulation of culture media to be used at different stages over the preimplantation period from fertilization to the fully expanded blastocyst stage. It has also prescribed the mouse embryo as a practical tool for quality control testing of the laboratory system in human in-vitro fertilization. Aspects of the physiology of both species that require further study are the physiological levels of endogenous inorganic phosphate in the female reproductive tract, the requirement for inorganic phosphate in culture medium, the specificity of the amino acid requirements for optimal development before and after compaction and the importance of including EDTA in culture medium.
Compact Object Descriptors from Local Colour Invariant Histograms (2006)

Much emphasis has recently been placed on the detection and recognition of locally (weak) affine invariant region descriptors for object recognition. In this paper, we take recognition one step further by developing features for non-planar objects. We consider the description of objects with locally smoothly varying surface. For this class of objects, colour invariant histogram matching has proven to be very encouraging. However, matching many local colour cubes is computationally demanding. We propose a compact colour descriptor, which we call Wiccest, requiring only 12 numbers to locally capture colour and texture information. The Wiccest features are shown to be fairly insensitive to photometric effects like shadow, shading, and illumination colour. Moreover, we demonstrate the features to be applicable to highly compressed images while retaining discriminative power.
Android Essentials (2008)

Android Essentials is a nofrills, nononsense, codecentric run through the guts of application development on Googles Mobile OS. This book uses the development of a sample application to work through topics, focusing on giving developers the essential tools and examples required to make viable commercial applications work. Covering the entirety of the Android catalog in less than 150 pages is simply impossible. Instead, this book focuses on just four main topics: the application life cycle and OS integration, user interface, locationbased services, and networking. Thorough, complete, and useful work on the nuts and bolts of applicatio development in Android Example driven and practically minded A tool for hobbyists and professionals who want to create productionquality applications What youll learn Understand how an Android application functions and communicates with the handset that hosts it. Comprehend the complexities of timers, services, and multimedia playback. Create and display a rich mix of customrendered screens and tailored Android widgets. Understand how locationbased services are becoming more and more important in the mobile world. See how to use Googles powerful Map tool. Explore the intricacies of network connectivity in the mobile world. Who is this book for This book is for professional software engineers looking to move their ideas and applications into the mobile space with Android. The author assumes the reader has a passable understanding of Java. They should be able to write classes and handle basic inheritance structures. This book also targets hobbyist developers looking to negotiate the complex minefield of mobile software.
Krummenacher feedback analysis for high-count-rate semiconductor pixel detector readout (2010)

The Krummenacher feedback circuit [1] is a well know and often used in charge sensitive amplifiers (CSA) connected to DC-coupled semiconductor detectors. The circuit provides in a very simple structure dual functionality: continuous reset and detector leakage current compensation. In spite of the simplicity the characterization of the circuit for high speed applications is not very straightforward. This article presents an analysis of the feedback circuit based on 90 nm CMOS and technology and targeted at high-count-rate semiconductor hybrid pixel detector applications realized in submicron or 3D technologies.
A Global Lottery and a Global Premium Bond (2003)

<p>The world lottery market now amounts to at least US$126 billion in sales. World market sales for all gaming products (public, charitable and commercial) total some US$1 trillion, of which Internet gambling accounts for US$32 billion. This paper assesses t</p>
Cardiology in Review (2016)

Division of Cardiology, Department of Medicine, New York Medical College/Westchester Medical Center, Valhalla, NY Disclosure: The author has no conflicts of interest to report.
The mRNA expression of IGF-1 and IGF-1R in human breast cancer: association with clinico-pathological parameters. (2006)

The insulin-like growth factor I (IGF-I) has been implicated in breast cancer development acting through insulin-like growth factor I receptor (IGF-IR). The objective of this study is to examine the correlation between levels of mRNA expression of IGF-1 and IGF-1R, and the clinicopathological parameters of breast cancer.
Both Major Histocompatibility Complex Class I (MHC-I) and MHC-II Molecules Are Required, while MHC-I Appears To Play a Critical Role in Host Defense against Primary Coxiella burnetii Infection (2018)

To understand the role of class I major histocompatibility complex (MHC-I) and class II MHC (MHC-II) antigen presentation pathways in host defense against <i>Coxiella burnetii</i> infection, we examined whether MHC-I or MHC-II deficiency in mice would significantly influence their susceptibility to virulent <i>C. burnetii</i> Nine Mile phase I (NMI) infection. The results indicate that NMI infection induced more severe disease in both MHC-I-deficient and MHC-II-deficient mice than in wild-type (WT) mice, while only MHC-I-deficient mice developed a severe persistent infection and were unable to control bacterial replication. These results suggest that both MHC-I-restricted CD8<sup>+</sup> T cells and MHC-II-restricted CD4<sup>+</sup> T cells contribute to host defense against primary <i>C. burnetii</i> infection, while MHC-I-restricted CD8<sup>+</sup> T cells appear to play a more critical role in controlling bacterial replication. Additionally, although NMI infection induced more severe disease in TAP1-deficient mice than in their WT counterparts, TAP1 deficiency in mice did not significantly influence their ability to eliminate <i>C. burnetii</i> This suggests that <i>C. burnetii</i> antigen presentation to CD8<sup>+</sup> T cells by the MHC-I classical pathway may depend only partially on TAP1. Furthermore, granzyme B deficiency in mice did not significantly alter their susceptibility to <i>C. burnetii</i> infection, but perforin-deficient mice were unable to control host inflammatory responses during primary <i>C. burnetii</i> infection. These results suggest that perforin, but not granzyme B, is required for <i>C. burnetii</i> antigen-specific cytotoxic CD8<sup>+</sup> T cells to control primary <i>C. burnetii</i> infection.
Theory of Flow Control in Shared Networks and Its Application in the Canadian Telephone Network (1981)

A shared network is largely oversubscribed by independent users who make random demands on the network. Network flow control is required for the orderly operation of the network under all potential traffic loads. This paper presents a qualitative analysis of the theory of flow control to circuit-switched and packet-switched networks and pro- ,. poses 4 complementary controls and 1 subtended control to constitute "flow control." They are traffic control, routing and delay control, congestion control, network management control, and end-end flow control. This paper introduces the concept of the "R-T function" to illustrate the synthesis of delays and routing freedoms, and to demonstrate the continuum between overload and congestion phenomena. The application of the qualitative theory of flow control to the Canadian Telephone Network is reviewed and the agreement between the theory and the practice is demonstrated. The telephone network is a prime example of a circuit-switched network which has received the benefit of extensive simulation and analytical studies, as well as a long experience to validate the conclusions reached in this paper.
Thrombin Induces Mast Cell Adhesion to Fibronectin: Evidence for Involvement of Protease-Activated Receptor-1 (2002)

Thrombin activates mast cells to release inflammatory mediators through a mechanism involving protease-activated receptor-1 (PAR-1). We hypothesized that PAR-1 activation would induce mast cell adhesion to fibronectin (FN). Fluorescent adhesion assay was performed in 96-well plates coated with FN (20 microg/ml). Murine bone marrow cultured mast cells (BMCMC) were used after 3-5 wk of culture (>98% mast cells by flow cytometry for c-Kit expression). Thrombin induced beta-hexosaminidase, IL-6, and matrix metalloproteinase-9 release from BMCMC. Thrombin and the PAR-1-activating peptide AparafluoroFRCyclohexylACitY-NH(2) (cit) induced BMCMC adhesion to FN in a dose-dependent fashion, while the PAR-1-inactive peptide FSLLRY-NH(2) had no effect. Thrombin and cit induced also BMCMC adhesion to laminin. Thrombin-mediated adhesion to FN was inhibited by anti-alpha(5) integrin Ab (51.1 +/- 6.7%; n = 5). The combination of anti-alpha(5) and anti-alpha(4) Abs induced higher inhibition (65.7 +/- 7.1%; n = 5). Unlike what is known for FcepsilonRI-mediated adhesion, PAR-1-mediated adhesion to FN did not increase mediator release. We then explored the signaling pathways involved in PAR-1-mediated mast cell adhesion. Thrombin and cit induced p44/42 and p38 phosphorylation. Pertussis toxin inhibited PAR-1-mediated BMCMC adhesion by 57.3 +/- 7.3% (n = 4), indicating that G(i) proteins are involved. Wortmannin and calphostin almost completely inhibited PAR-1-mediated mast cell adhesion, indicating that PI-3 kinase and protein kinase C are involved. Adhesion was partially inhibited by the mitogen-activated protein kinase kinase 1/2 inhibitor U0126 (24.5 +/- 3.3%; n = 3) and the p38 inhibitor SB203580 (25.1 +/- 10.4%; n = 3). The two inhibitors had additive effects. Therefore, thrombin mediates mast cell adhesion through the activation of G(i) proteins, phosphoinositol 3-kinase, protein kinase C, and mitogen-activated protein kinase pathways.
Automated Retrieval of CT Images of Liver Lesions on the Basis of Image Similarity: Method and Preliminary Results (2010)

Preliminary assessment of this approach shows excellent retrieval results for three types of liver lesions visible on portal venous CT images, warranting continued development and validation in a larger and more comprehensive database.
Tobramycin: An Overview (1976)

Journal Article Tobramycin: An Overview Get access Harold C. Neu Harold C. Neu Division of Infectious Diseases, College of Physicians and Surgeons, Columbia University, New York, New York Please address requests for reprints to Dr. Harold C. Neu, Division of Infectious Diseases, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, New York 10032. Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Infectious Diseases, Volume 134, Issue Supplement_1, August 1976, Pages S3–S19, https://doi.org/10.1093/infdis/134.Supplement_1.S3 Published: 01 August 1976