gebhart/patrepeval huggingface dataset:
Gustatory responses of eel palatine receptors to amino acids and carboxylic acids. (1979)

The gustatory receptors of the eel palate were found to be extremely sensitive to amino acids and carboxylic acids. The results obtained are as follows: (a) 11 amino acids which are among naturally occurring amino acids elicited responses in the palatine nerve, but 9 amino acids did not elicit a response even at a high concentration. The effect of D-amino acids was always much less than that of their corresponding L-isomers. There was no appreciable difference in the effectiveness of an alpha-amino acid (alpha-alanine) and beta-amino acid (beta-alanine). (b) The threshold concentrations of the most potent amino acids (arginine, glycine) were between 10(-8) and 10(-9) M. A linear relation between the magnitude of the response and log stimulus concentration held for a wide concentration range for all the amino acids examined. (c) The palatine receptors responded sensitively to various carboxylic acid solutions whose pH was adjusted to neutral. The threshold concentrations varied between 10(-4) and 10(-7) M. The magnitude of the response at 10(-2) M increased with an increase of carbon chain length. (d) The extent of cross-adaptation was examined with various combinations of amino acids. A variety of the response patterns showing complete cross-adaptation, no cross-adaptation, or synergetic interaction was observed. The synergetic interaction was also observed when one amino acid below its threshold concentration was added to the other amino acid below its threshold concentration was added to the other amino acid. No cross-adaptation was observed between amino acids and fatty acids. (e) The treatment of the palate with papain led to loss of the responses to arginine, glycine, and histidine without affecting those to proline and acetic acid. The treatment with pronase E eliminated selectively the response to proline. The possibility that the eel gustatory receptors are responsible for sensing food at a distance was discussed.
Traffic Density Estimation using a Convolutional Neural Network (2018)

The goal of this project is to introduce and present a machine learning application that aims to improve the quality of life of people in Singapore. In particular, we investigate the use of machine learning solutions to tackle the problem of traffic congestion in Singapore. In layman's terms, we seek to make Singapore (or any other city) a smoother place. To accomplish this aim, we present an end-to-end system comprising of 1. A traffic density estimation algorithm at traffic lights/junctions and 2. a suitable traffic signal control algorithms that make use of the density information for better traffic control. Traffic density estimation can be obtained from traffic junction images using various machine learning techniques (combined with CV tools). After research into various advanced machine learning methods, we decided on convolutional neural networks (CNNs). We conducted experiments on our algorithms, using the publicly available traffic camera dataset published by the Land Transport Authority (LTA) to demonstrate the feasibility of this approach. With these traffic density estimates, different traffic algorithms can be applied to minimize congestion at traffic junctions in general.
γ-Secretase Substrate Selectivity Can Be Modulated Directly via Interaction with a Nucleotide-binding Site (2005)

gamma-Secretase is an unusual protease with an intramembrane catalytic site that cleaves many type I membrane proteins, including the amyloid beta-protein (Abeta) precursor (APP) and the Notch receptor. Genetic and biochemical studies have identified four membrane proteins as components of gamma-secretase: heterodimeric presenilin composed of its N- and C-terminal fragments, nicastrin, Aph-1, and Pen-2. Here we demonstrated that certain compounds, including protein kinase inhibitors and their derivatives, act directly on purified gamma-secretase to selectively block cleavage of APP- but not Notch-based substrates. Moreover, ATP activated the generation of the APP intracellular domain and Abeta, but not the generation of the Notch intracellular domain by the purified protease complex, and was a direct competitor of the APP-selective inhibitors, as were other nucleotides. In accord, purified gamma-secretase bound specifically to an ATP-linked resin. Finally, a photoactivable ATP analog specifically labeled presenilin 1-C-terminal fragments in purified gamma-secretase preparations; the labeling was blocked by ATP itself and APP-selective gamma-secretase inhibitors. We concluded that a nucleotide-binding site exists within gamma-secretase, and certain compounds that bind to this site can specifically modulate the generation of Abeta while sparing Notch. Drugs targeting the gamma-secretase nucleotide-binding site represent an attractive strategy for safely treating Alzheimer disease.
Combined evoked potentials in co-occuring attention deficit hyperactivity disorder and epilepsy. (2011)

Disturbances produced by the presence of ADHD-epilepsy comorbidity reveal hypothetically a linked physiopathological path for both diseases, and offers an approach with possible diagnostic importance, combined evoked potential recordings.
Flow and Thrombosis at Orifices Simulating Mechanical Heart Valve Leakage Regions (2005)

Using the present method, a significant increase in TAT concentration was found for 200 and 400 microm orifices, but not 800 and 1200 microm orifices, indicating that these flow geometries exhibit a critical threshold for activation of coagulation and resulting formation of thrombus. Markedly lower TAT levels were produced in studies with platelet-depleted blood, documenting a key role for platelets in the thrombotic process.
DWDM reconfigurable optical delay buffer for optical packet switched networks (2006)

We proposed and demonstrated a novel scheme to realize wavelength-selective reconfigurable optical delay buffers using optical fiber delay in a folded-path architecture. The experimental results show that multiple wavelength 10-Gb/s dense wavelength-division-multiplexed packets with 50-GHz channel spacing can individually be delayed a variable amount of time simultaneously with a power penalty less than 1 dB using the proposed reconfigurable buffer architecture.
Block level voltage (2004)

Over the past years, state-of-art power optimization methods move towards higher abstraction levels that result in more efficient power savings. Among existing power optimization approaches, dynamic power management (DPM) is considered to be one of the most effective strategies. Depending on abstraction levels, DPM can be implemented in different formats but here we focus on scheduling that is more suitable for real-time system design use. This differs from the concurrent scheduling approaches that start from either the HLS (High-Level Synthesis) or RTS (Real-Time System) point of view, we propose a synergy solution of both approaches, namely block-level voltage/frequency scheduling (BLVFS). The presented block-level voltage/ frequency scheduling approach shows a generic solution for low power SoC (System on Chip) system design while the approaches which belong to the HLS and RTS categories have a strong dependency on the system functionalities. Consider a SoC as a combination of heterogeneous functional blocks, our approach provides efficient power savings by dynamically scheduling the scaling of voltage and frequency at the same time. Simulation results indicate that by using heuristic based strategies significant power savings can be achieved.
Internal fingerprint zone detection in optical coherence tomography fingertip scans (2015)

Optical coherence tomography (OCT) is a high-resolution imaging technology capable of capturing a three-dimensional (3-D) representation of fingertip skin. The papillary junction—a junction layer of skin containing the same topographical features as the surface fingerprint—is contained within this representation. The top edge of the papillary junction contains the topographical information pertinent to the internal fingerprint. Extracting the internal fingerprint from OCT fingertip scans has been shown to be possible. Currently, acquiring the internal fingerprint involves manually defining the region containing it. This manner of definition is inefficient. Perfect knowledge of the location of the papillary junction is hypothesized as achievable. This research details and tests a k-means clustering approach for papillary junction detection. All tested metrics are of a standard comparable to the measured human error. The technique presented in this research is highly successful in detection of the location of the papillary junction. Furthermore, high-quality internal fingerprints are acquired using the coordinates obtained.
Control of internal stress and Young’s modulus of Si3N4 and polycrystalline silicon thin films using the ion implantation technique (1990)

Boron and phosphorus ions are implanted in order to control the internal stress and Young’s modulus of 200-nm-thick silicon nitride and polycrystalline silicon films prepared by low-pressure chemical vapor deposition. These ions are implanted into the middle layer of the films at doses of 1×1014 and 1×1015/cm2, then the films are annealed at 900 °C. The internal stress and Young’s modulus of these films are measured by a rectangular membrane load deflection technique [Tech. Digest, IEEE Micro Electromechanical Systems Workshop, IEEE, Salt Lake City, UT, 1989, p. 152]. Both internal stress and Young’s modulus of the silicon nitride film decrease with dose, while those of the polycrystalline silicon film do not necessarily decrease.
Crystal Morphology and Growth in Annealed Rubrene Thin Films (2016)

While controlled crystallization of organic thin films holds great potential for enhancing the performance of electronic devices, quantitative understanding of the processes involved is limited. Here, we characterize the thin film crystal growth of the organic semiconductor rubrene during annealing using polarized optical microscopy with a heated stage for in situ measurements, followed by atomic force microscopy and X-ray diffraction. During annealing, the film undergoes transitions from predominant growth of a polycrystalline triclinic crystal structure to single crystal orthorhombic, followed by polycrystalline growth of the orthorhombic polymorph. Observation of crystal morphology with time allows determination of the crystal orientation, which is used in conjunction with crystal size measurements to determine the crystallization activation energies for the observed growth phases and crystal planes.
Spinning Disc Reactor for Green Processing and Synthesis (2013)

This chapter contains sections titled: Introduction Design and Operating Features of SDRs Characteristics of SDRs Case Studies: SDR Application for Green Chemical Processing and Synthesis Hurdles to Industry Implementation Conclusion Nomenclature Greek Letters Subscripts References
Ovulation induction and luteal support with GnRH agonist in patients at high risk for hyperstimulation syndrome (2015)

The aim of this study was to compare GnRHa trigger and luteal addition of triptorelin to hCG trigger for final oocyte maturation in women at high risk for OHSS undergoing IVF. A total of 423 patients were divided in two groups both stimulated using antagonist short protocol. Gonadotropins 75-150 UI/day were started on day 2-5, GnRH antagonist was added when the lead follicle was >14 mm and the final trigger was obtained with hCG 250 µg or triptorelin 0.2 mg. The luteal phase was supported with progesterone alone in the hCG group, with progesterone plus triptorelin 0.1 every other day from embryo transfer in the triptorelin group. In the triptorelin group we did neither have to suspend any embryo transfer, nor we have any early clinical OHSS. In the control group, 13 patients were suspended due to symptomatic high risk for OHSS and two patients developed a clinically significant OHSS. No statistically significant difference was observed in terms of clinical and ongoing pregnancy rates and implantation rates. Our results indicate that a protocol including GnRHa as trigger and an intensive luteal phase supported with GnRHa is safer than a standard antagonist protocol using hCG as trigger. It displays similar results, therefore it can be used as the first choice in patients at high risk for OHSS.
A Robust Technique for Assembly of Nucleic Acid Hybridization Chips Based on Electrochemically Templated Chitosan (2003)

A nucleic acid hybridization assay was assembled onto a robust and readily addressable silicon-based chip using polysaccharide chitosan as a scaffold for the covalent coupling of probe DNA to the chip's surface. Chitosan is a unique polymer, ideally suited for this application because its net charge and solubility are pH dependent. Specifically in this work, gold-patterned electrodes were created using standard photolithographic techniques, chitosan was electrodeposited in a spatially resolved manner onto the polarized electrodes, probe DNA was covalently assembled onto the chitosan, and both DNA:DNA and DNA:mRNA hybridization detection schemes were evaluated. Hybridization of target nucleic acid was quantifiable, reproducible, and robust; the surface was regenerated and rehybridized up to eight times without loss of signal. Finally, transcriptional upregulation of the Escherichia coli chaperone, DnaK, which is an indicator of cellular stress, was observed using the hybridization chip sandwich assay. Thus, this method enables rapid and facile monitoring of gene expression in a format that is reusable and requires minimal reagent quantities.
Binding of Nitric Oxide and Carbon Monoxide to Soluble Guanylate Cyclase As Observed with Resonance Raman Spectroscopy (1996)

Resonance Raman spectra have been recorded for the ferrous heme of soluble guanylate cyclase (sGC), the only receptor known thus far for .NO. On the basis of the frequencies of porphyrin core sensitive vibrations in the high frequency region of the Raman spectrum, we conclude that the ferrous heme is five-coordinate, high spin, when no exogenous ligands are present. We assign a prominent vibration that occurs at 204 cm-1 in the reduced enzyme to the heme Fe(2+)-proximal histidine stretching vibration. In the .NO bound form of the enzyme, the heme Fe2+ retains a five-coordinate geometry. Assuming that .NO binds to the distal side of the heme, this observation indicates that the weak Fe-His bond breaks when .NO binds. Two isotope-sensitive vibrations are observed in the .NO bound enzyme, one at 1677 cm-1, attributed to the N-O stretching vibration, and one at 525 cm-1, attributed to the Fe-NO stretching vibration. When CO is bound to the ferrous heme, the heme ligation is six-coordinate. From this, we conclude that the Fe-His bond is still intact and that, if cleavage of the Fe-proximal ligand bond is necessary for complete activation of sGC, then CO should only weakly activate the enzyme, which has been shown to be the case. In the carbonmonoxy enzyme, the Fe-CO stretching vibration is observed at 472 cm-1 and the Fe-C-O bending vibration is detected at 562 cm-1. These frequencies are the lowest yet observed for the Fe-CO stretching and Fe-C-O bending modes in heme proteins or model systems with imidazole as the proximal ligand and suggest that there is significant negative polarity in the distal pocket. The negative polarity and the low frequency of the Fe-His stretching vibration may account for the very low O2 affinity of sGC.
Capturing CO2 from Biogas Plants (2017)

As a renewable energy, biogas produced from anaerobic digestion and landfill is playing a more and more important role in the energy market. Capturing CO2 from biogas can result in a negative CO2 emission. Depending on how biogas is utilized, there are different routes to capture CO2. A biogas plant that uses raw biogas to produce power and heat can be retrofitted by integrating CO2 capture. In order to identify the best option, three retrofits were compared from both technical and economic perspectives, including SYS-I, which captures CO2 from raw gas and produces biomethane instead of electricity and heat, SYS-II, which captures CO2 using MEA-based chemical absorption after the combustion of raw gas, and SYS-III, which captures CO2 by using oxy-fuel combustion of the raw gas. In general, SYS-I can achieve the highest profit and shortest payback time, mainly due to the high price of biomethane. SYSII and SYS-III are clearly influenced by carbon credit. In order to have positive profits for the retrofits of SYS-II and SYS-III, carbon credit needs to exceed 750SEK (or 100USD)/ton CO2 and 113 SEK (or 15USD)/ton CO2 respectively.
Flight testing of a wing deflection measurement method (1995)

A research programme has been executed to evaluate candidate wing deflection measurement methods. The following two methods have been selected and flight tested: (1) an optical method based on the use of a video camera to record a black-and-white stripe pattern on the outerwing surface followed by post-flight image processing and (2) an accelerometer method based on the combined use of an accelerometer package located in the wing tip and an inertial reference system located close to the wing root. Results of these two methods are compared. The optical method performs better. Accuracies (20 values) have been achieved of 0.08 in twist and 2 mm in heave at the wing tip.
Effects of MSC Coadministration and Route of Delivery on Cord Blood Hematopoietic Stem Cell Engraftment (2013)

Hematopoietic stem cell transplantation (HSCT) using umbilical cord blood (UCB) progenitors is increasingly being used. One of the problems that may arise after UCB transplantation is an impaired engraftment. Either intrabone (IB) injection of hematopoietic progenitors or mesenchymal stem cell (MSC) coadministration has been proposed among the strategies to improve engraftment. In the current study, we have assessed the effects of both approaches. Thus, NOD/SCID recipients were transplanted with human UCB CD34+ cells administered either intravenously (IV) or IB, receiving or not bone marrow (BM)-derived MSCs also IV or IB (in the right femur). Human HSC engraftment was measured 3 and 6 weeks after transplantation. Injected MSCs were tracked weekly by bioluminescence. Also, lodgment within the BM niche was assessed at the latter time point by immuno-fluorescence. Our study shows regarding HSC engraftment that the number of BM human CD45+ cells detected 3 weeks after transplantation was significantly higher in mice cotransplanted with human MSCs. Moreover, these mice had a higher myeloid (CD13+) engraftment and a faster B-cell (CD19+) chimerism. At the late time point evaluated (6 weeks), human engraftment was higher in the group in which both strategies were employed (IB injection of HSC and MSC coadministration). When assessing human MSC administration route, we were able to track MSCs only in the injected femurs, whereas they lost their signal in the contralateral bones. These human MSCs were mainly located around blood vessels in the subendosteal region. In summary, our study shows that MSC coadministration can enhance HSC engraftment in our xenogenic transplantation model, as well as IB administration of the CD34+ cells does. The combination of both strategies seems to be synergistic. Interestingly, MSCs were detected only where they were IB injected contributing to the vascular niche.
Adenosine receptor ligands as potential therapeutics in asthma. (2002)

Increasingly persuasive evidence implicates adenosine in the pathophysiology of asthma. Adenosine exerts its manifold biological activities by interacting with at least four adenosine receptor subtypes. Selective activation or blockade of these sites is being exploited by the pharmaceutical industry in an attempt to generate novel therapies for asthma. Compounds have been designed which downregulate the A1 receptor, activate the A2A receptor or block the A2B receptor and are currently in development for this condition.
On Incremental High Utility Sequential Pattern Mining (2018)

High utility sequential pattern (HUSP) mining is an emerging topic in pattern mining, and only a few algorithms have been proposed to address it. In practice, most sequence databases usually grow over time, and it is inefficient for existing algorithms to mine HUSPs from scratch when databases grow with a small portion of updates. In view of this, we propose the IncUSP-Miner + algorithm to mine HUSPs incrementally. Specifically, to avoid redundant re-computations, we propose a tighter upper bound of the utility of a sequence, called Tight Sequence Utility (TSU), and then we design a novel data structure, called the candidate pattern tree, to buffer the sequences whose TSU values are greater than or equal to the minimum utility threshold in the original database. Accordingly, to avoid keeping a huge amount of utility information for each sequence, a set of concise utility information is designed to be stored in each tree node. To improve the mining efficiency, several strategies are proposed to reduce the amount of computation for utility update and the scopes of database scans. Moreover, several strategies are also proposed to properly adjust the candidate pattern tree for the support of multiple database updates. Experimental results on some real and synthetic datasets show that IncUSP-Miner + is able to efficiently mine HUSPs incrementally.
Understanding the Entanglement: Neutrophil Extracellular Traps (NETs) in Cystic Fibrosis (2017)

Cystic fibrosis (CF) is an autosomal recessive disorder caused by mutations in the gene that codes for the CF trans-membrane conductance regulator. These mutations result in abnormal secretions viscous airways of the lungs, favoring pulmonary infection and inflammation in the middle of neutrophil recruitment. Recently it was described that neutrophils can contribute with disease pathology by extruding large amounts of nuclear material through a mechanism of cell death known as Neutrophil Extracellular Traps (NETs) into the airways of patients with CF. Additionally, NETs production can contribute to airway colonization with bacteria, since they are the microorganisms most frequently found in these patients. In this review, we will discuss the implication of individual or mixed bacterial infections that most often colonize the lung of patients with CF, and the NETs role on the disease.
Ronaldo Menéndez: un pequeño filósofo frustrado (2006)

Errors in ICU transfer reports are frequent and may be potentially harmful. ICU nurses may help to effectively and accurately intercept those inaccuracies, and therefore reduce the exportation of errors from the ICU to the ward.