gebhart/patrepeval huggingface dataset:
Interleukin 6 stimulates growth of vascular smooth muscle cells in a PDGF-dependent manner (1991)

We have investigated the effect of interleukin 6 (IL-6) on the growth of vascular smooth muscle cells (VSMC) isolated from rat aortas. Murine recombinant IL-6 significantly increased the number of VSMC and stimulated tritiated thymidine incorporation into VSMC in a dose-dependent manner. The IL-6-induced thymidine incorporation into VSMC was totally inhibited by the Ca2+ channel blocker verapamil; however, IL-6 showed no effects on the intracellular Ca2+ level ([Ca2+]i) in VSMC. Antibody against platelet-derived growth factor (PDGF) also totally inhibited the IL-6-induced thymidine uptake. PDGF caused a significant increase in the [Ca2+]i, which was totally inhibited by verapamil. IL-6 mRNA was not detected in unstimulated "quiescent" VSMC, but its expression was stimulated by exposure of VSMC to 10% fetal bovine serum. Immunohistochemical study using anti-PDGF antibody showed that IL-6 stimulated PDGF production in VSMC. These results support the premise that IL-6 is released by VSMC in an autocrine manner and promotes the growth of VSMC via induction of endogenous PDGF production.
CHARACTERIZATION OF THE STRATEGY CREATION IN FOREX MARKET ORGANIZATIONS (2012)

The purpose of this research is to determine the characteristics of strategic approaches adopted by Forex market organizations in the strategy creation process, since the typology used by 10 schools of strategy Mintzberg, Ahlstrand and Lampel (1998). The dimensions of study adopted were: the adopted and desired strategic approach, the strategic process, content and strategy context. The target population included the FX traders (FX acronym for Foreign Exchange) from forty two countries including Colombia. The main findings include the trend of the organizations to change from a strategic approach to an approach based on market positions, clearly pre-formulated in the following directions: first, towards an approach based on pre-formulation but with simplicity in the variables to consider; second, a strategy change oriented to a learning approach without the rigidity of pre-formulation; and finally, an approach that seeks for alliances with other agents beyond the economic view.
Non contact measurement of vibration using airborne ultrasound (2002)

A non contact ultrasonic method for measuring the surface vibration of objects is studied. The instrument consists in a pair of 420 kHz air transducer. One is used to emit ultrasound toward the moving surface while the other receives the ultrasound reflected from the object under test. Two effects induce a phase modulation on the received signal. The first results from the variation of the round trip time interval /spl tau/ required for the wavefront to go from the emitter to the moving surface and back to the receiver. This is the Doppler effect directly proportional to the surface displacement. The second one results from the nonlinear parametric interactions of the ultrasonic beams (forward and backward) with the low frequency sound field emitted in the air by the vibrating surface. This latter phenomenon, which is a volume effect, is proportional to the low frequency field and then to the surface velocity. The relative contribution of Doppler and parametric effects are evaluated, and it is shown that both have to be taken into account when sensing broadband vibrations in the air.
Does Cesarean Section Reduce Postpartum Urinary Incontinence? A Systematic Review (2007)

Although short-term occurrence of any degree of postpartum stress urinary incontinence is reduced with cesarean section, severe symptoms are equivalent by mode of birth. Risk of postpartum stress urinary incontinence must be considered in the context of associated maternal and newborn morbidity and mortality.
FdhTU-Modulated Formate Dehydrogenase Expression and Electron Donor Availability Enhance Recovery of<i>Campylobacter jejuni</i>following Host Cell Infection (2012)

Campylobacter jejuni is a food-borne bacterial pathogen that colonizes the intestinal tract and causes severe gastroenteritis. Interaction with host epithelial cells is thought to enhance severity of disease, and the ability of C. jejuni to modulate its metabolism in different in vivo and environmental niches contributes to its success as a pathogen. A C. jejuni operon comprising two genes that we designated fdhT (CJJ81176_1492) and fdhU (CJJ81176_1493) is conserved in many bacterial species. Deletion of fdhT or fdhU in C. jejuni resulted in apparent defects in adherence and/or invasion of Caco-2 epithelial cells when assessed by CFU enumeration on standard Mueller-Hinton agar. However, fluorescence microscopy indicated that each mutant invaded cells at wild-type levels, instead suggesting roles for FdhTU in either intracellular survival or postinvasion recovery. The loss of fdhU caused reduced mRNA levels of formate dehydrogenase (FDH) genes and a severe defect in FDH activity. Cell infection phenotypes of a mutant deleted for the FdhA subunit of FDH and an ΔfdhU ΔfdhA double mutant were similar to those of a ΔfdhU mutant, which likewise suggested that FdhU and FdhA function in the same pathway. Cell infection assays followed by CFU enumeration on plates supplemented with sodium sulfite abolished the ΔfdhU and ΔfdhA mutant defects and resulted in significantly enhanced recovery of all strains, including wild type, at the invasion and intracellular survival time points. Collectively, our data indicate that FdhTU and FDH are required for optimal recovery following cell infection and suggest that C. jejuni alters its metabolic potential in the intracellular environment.
Using Multi-Stage Features in Fast R-CNN for Pedestrian Detection (2016)

Pedestrian detection and tracking remains popular issue in computer vision, with many applications in robotics, surveillance, security and telecare systems, especially when connected with Smart Cities and Smart Destinations. As a particular case of object detection, pedestrian detection in general is a difficult task due to a large variability of features due to different scales, views and occlusion. Typically, smaller and occluded pedestrians are hard to detect due to fewer discriminative features if compared to large-size, visible pedestrians. In order to overcome this, we use convolutional features from different stages in a deep Convolutional Neural Network (CNN), with the idea of combining more global features with finer details. In this paper we present an object detection framework based on multi-stage convolutional features for pedestrian detection. This framework extends the Fast R-CNN framework for the combination of several convolutional features from different stages of the used CNN to improve the network's detection accuracy. The Caltech Pedestrian dataset was used to train and evaluate the proposed method.
Optimal scheduling and control of a multi-pump boosting system (2010)

An optimal scheduling and control method for a multiple pump system is proposed from the energy efficient point of view. The model-based optimal problem is first formulated and then converted to be a mixed integer nonlinear programming problem. The proposed method provides an optimal solution regarding to how many and which available pumps should be put into operation when the (head) demand to the system and/or system operating condition changes. The running speeds of operating pumps are also derived by the proposed algorithm. A feedback control mechanism is also introduced into the considered framework in order to enhance the system tracking performance and robustness. A nonlinear programming solution is derived and implemented in a testing facility. The experimental results show a clear and huge potential to improve multi-pump system's efficiency using the proposed algorithm and framework.
Chemokine receptor–8 (CCR8) mediates human vascular smooth muscle cell chemotaxis and metalloproteinase-2 secretion (2003)

The response of the arterial vascular wall to injury is characterized by vascular smooth muscle cell (VSMC) migration, a process requiring metalloproteinase production. This migration is induced by cytokines, however the agonists involved are not fully defined. The CC chemokine receptor 8 (CCR8) is expressed on monocytes and T lymphocytes and is the sole receptor for the human CC chemokine 1 (CCL1, I-309) and for the viral chemokine, vCCL1 (viral macrophage inflammatory protein 1 [vMIP-1]). We have reported that CCR8 is expressed on human umbilical vein endothelial cells (HUVECs) and mediates chemotaxis induced by CCL1. The conditioned medium from incubation mixtures of lipoprotein(a) (Lp(a)) and HUVECs (LCM) contained CCL1 and stimulated both monocyte and HUVEC chemotaxis, providing novel mechanisms for the atherogenicity of Lp(a). We now report that CCL1, vCCL1, and LCM stimulate chemotaxis of human VSMCs that is blocked by murine monoclonal antibody against CCR8 and by the G-protein inhibitor pertussis toxin. The effect of anti-CCR8 was specific, as this antibody failed to effect the chemotaxis of VSMCs in response to CCL3 or by platelet-derived growth factor BB (PDGF-BB). VSMCs contained CCR8 mRNA and CCR8 antigen coprecipitated with VSMC membranes. Antibodies against metalloproteinase-2 (MMP-2) inhibited the CCL1-induced chemotaxis of VSMCs, whereas anti-MMP-9 was less effective. CCL1 induced VSMC pro-MMP-2 mRNA and protein secretion. Poxvirus MC148 inhibited the increase in MMP-2 induced by CCL1, documenting that CCR8 was the receptor responsible. In mouse femoral arteries, CCR8 and TCA3 antigen colocalized with VSMCs and were up-regulated after injury. The induction of CCR8 and CCL1/TCA3 under conditions associated with VSMC proliferation and migration raises the possibility that CCR8 may play an important role in vessel wall pathology.
Intracardiac injection of erythropoietin induces stem cell recruitment and improves cardiac functions in a rat myocardial infarction model (2008)

Erythropoietin (EPO) protects the myocardium from ischaemic injury and promotes beneficial remodelling. We assessed the therapeutic efficacy of intracardiac EPO injection and EPO-mediated stem cell homing in a rat myocardial infarction (MI) model. Following MI, EPO (3000 U/kg) or saline was delivered by intracardiac injection. Compared to myocardial infarction control group (MIC), EPO significantly improved left ventricular function (n =11-14, P < 0.05) and decreased right ventricular wall stress (n = 8, P < 0.05) assessed by pressure-volume loops after 6 weeks. MI-EPO hearts exhibited smaller infarction size (20.1 +/- 1.1% versus 27.8 +/- 1.2%; n = 6-8, P < 0.001) and greater capillary density (338.5 +/- 14.7 versus 259.8 +/- 9.2 vessels per mm2; n = 6-8, P < 0.001) than MIC hearts. Direct EPO injection reduced post-MI myocardial apoptosis by approximately 41% (0.27 +/- 0.03% versus 0.42 +/- 0.03%; n = 6, P= 0.005). The chemoattractant SDF-1 was up-regulated significantly assessed by quantitative realtime PCR and immunohistology. c-Kit(+) and CD34(+) stem cells were significantly more numerous in MI-EPO than in MIC at 24 hrs in peripheral blood (n = 7, P < 0.05) and 48 hrs in the infarcted hearts (n = 6, P < 0.001). Further, the mRNAs of Akt, eNOS and EPO receptor were significantly enhanced in MI-EPO hearts (n = 7, P < 0.05). Intracardiac EPO injection restores myocardial functions following MI, which may attribute to the improved early recruitment of c-Kit(+) and CD34(+) stem cells via the enhanced expression of chemoattractant SDF-1.
<i>BCL8</i> , a novel gene involved in translocations affecting band 15q11–13 in diffuse large-cell lymphoma (1997)

Translocations affecting the chromosomal region 15q11-13 and various other partners are recurrent in diffuse large-cell lymphomas (DLCL). To identify the putative gene, here named BCL8, involved in these translocations we have cloned the breakpoint region from a DLCL patient with t(14;15)(q32;q11-13) and the corresponding germ-line region from chromosome 15. The genomic locus on chromosome 15 is clonally rearranged in about 4% of DLCL in agreement with the frequency of 15q11-13 translocations. A probe derived from the BCL8 locus on chromosome 15 detected a transcript in human testis and prostate, whereas no expression was found in spleen, thymus, and blood leukocytes. Analysis of the BCL8 cDNA clones isolated from human testis cDNA library showed that the BCL8 gene generates a major transcript of 2.6 kb and a less prominent 4.5-kb species due to differential polyadenylylation. By reverse transcription-PCR analysis of RNA extracted from frozen DLCL samples and lymphoma cell lines, BCL8 expression was detected in all patients carrying 15q11-13 abnormalities and in a fraction of randomly selected DLCL patients. These results suggest that the BCL8 gene is not normally expressed in lymphoid tissues, but its expression can be activated by chromosomal translocation or by other mechanisms in DLCL. Ectopic expression of BCL8 in a significant proportion of DLCL suggests an important role for this gene in the molecular pathogenesis of B cell lymphoma.
High Prevalence of Dihydropteroate Synthase Mutations in <i>Pneumocystis jirovecii</i> Isolated from Patients with <i>Pneumocystis</i> Pneumonia in South Africa (2010)

Pneumocystis jirovecii pneumonia (PCP) is an important cause of morbidity and mortality in immunocompromised patients. Sulfa-containing drugs are used for the treatment and prophylaxis of PCP. Mutations in the P. jirovecii fas gene, which encodes dihydropteroate synthase (DHPS), are associated with prior exposure to sulfa drugs, and their appearance suggests the emergence of variants with reduced sulfa susceptibility. The present study examined the prevalence of DHPS mutations in P. jirovecii strains isolated from South African patients with PCP. P. jirovecii infection was investigated by immunofluorescence microscopy and quantitative real-time PCR with respiratory specimens from 712 patients (93% of whom were >15 years of age) with suspected PCP consecutively received for the detection of P. jirovecii over 1 year. PCR amplification and sequencing of the DHPS fas gene was attempted with DNA from the P. jirovecii-positive samples. P. jirovecii infection was confirmed by immunofluorescence microscopy in 168/712 (24%) of the patients. Carriage of the fungus was revealed by real-time PCR in 17% of the patients with negative microscopy results. The P. jirovecii fas gene was successfully amplified from specimens from 151 patients and sequenced. Mutations resulting in the Thr55Ala and/or Pro57Ser amino acid substitution were detected in P. jirovecii strains from 85/151 (56%) patients. The high frequency of PCP episodes with P. jirovecii harboring DHPS mutations in South Africa indicates that populations of this fungus are evolving under the considerable selective pressure exerted by sulfa-containing antibiotics. These results, similar to previous observations of sulfa drug resistance in bacterial populations, underscore the importance of the rational use of sulfa medications either prophylactically against PCP or for the treatment of other infections.
A Comparative Study on the Pozzolanic Activity between Nano-SiO2 and Silica Fume (2006)

nano-SiO_2 和硅石烟的凝硬性的活动被 X- 比较地学习 -- 光线衍射(XRD ) ，微分扫描热量测定(DSC ) ，扫描电子显微镜学(SEM ) 并且压缩，变硬的浆糊和水泥的债券和弯曲强度也被测量。结果显示粘贴的压缩强度开发用 Ca 做了(哦) _2 和 nano-SiO_2 ， Ca 的反应率(哦)有从 Ca 的 nano-SiO_2 和速度 ofC-S-H 胶化形成的 _2 (哦)有 nano-SiO_2 的 _2 Ca 在那些上显示出显著增加(哦) _2with 硅石烟。而且，在在总数和变硬的水泥(灰) 浆之间的接口的契约力量，和水泥的弯曲强度合并了与。3% NS 与 SF 多于那些增加了，特别在早年龄。总结， nano SiO_2 的凝硬性的活动比硅石烟的大得多。结果与 nano-SiO2 的小数量建议那， Ca (哦) 在在变硬的水泥(灰) 浆之间的接口的 _2 水晶并且，在早年龄的总数可以是。有效地专心于高效水泥。
Health–Related ICT Solutions of Smart Environments for Elderly–Systematic Review (2020)

By improving the quality of life and extending the length of life, Western society is becoming an increasingly ageing population with a higher proportion of seniors. From another point of view, there is a critical shortage of care staff, both in hospitals and for in-home care. Thanks to new technology trends such as Smart Homes and Smart Furniture, there is an opportunity for increased support for seniors by utilizing new technologies. This paper presents the current trends and possibilities in applying smart information and communications technology (ICT) solutions for in-home care concerning diseases in old age. The paper consists of a systematic review according to the PRISMA methodology of the available literature in Web of Science, IEEE Xplore, PubMed, Springer, and the Espacenet patent database. Publications report the usage of some types of artificial intelligence and their implementation and non-intrusive sensing technologies. The patents review identified solutions with a focus on monitoring the state of older adults and mobility improvement. Existing ICT smart solutions must address the following issues: (1) ease-of-use; (2) invisibility and disuse that isolate older adults; (3) privacy and security; (4) affordability of technology in terms of cost; and (5) supporting elderly individuals to stay in their homes or move in different environments independently. There is a significant gap between a large number of scientific publications and commercial solutions. The existing products reflect the specifics of the diseases in a rather wider context instead of the fulfilment of exact needs. It is often stated that such devices can be used across diseases, but the direct connection and benefits for the disease is still rather weak. The challenge remains to tap the existing potential of a large number of innovative ideas on the market and improve the quality of life.
Application of ubiquinone systems and electrophoretic comparison of enzymes to identification of clinical isolates of Aspergillus fumigatus and several other species of Aspergillus (1992)

The ubiquinone systems and electrophoretic comparison of enzymes were used to determine the relatedness among 64 isolates of seven Aspergillus spp. These were 31 clinical and 3 nonclinical isolates of Aspergillus fumigatus Fres., 2 isolates of A. nidulellus Samson & W. Gams, 8 isolates of A. terreus Thom, 4 isolates of A. flavus Link, 1 isolate of A. oryzae (Ahlburg) Cohn, 14 isolates of A. niger van Tieghem, and 1 isolate of A. japonicus Saito. The enzymes glucose 6-phosphate dehydrogenase, lactate dehydrogenase, glutamate dehydrogenase, fumarase, and malate dehydrogenase were examined. The relative mobilities were analyzed numerically. The results were presented as a dendrogram. Isolates from clinical and nonclinical sources within the same species had identical ubiquinone systems and identical or very similar enzyme patterns. In the dendrogram, 64 of the tested isolates were separated into seven major clusters at a 60% similarity level. Each major cluster corresponds to a single species. On the dendrogram, A. fumigatus isolates showed homogeneity, whereas A. niger isolates showed relative heterogeneity; in particular, A. niger MF-24 and the other A. niger isolates were distantly linked to each other. All A. fumigatus isolates had the Q-10 ubiquinone system and formed a single major cluster at a similarity level of 73% or greater. Glucose 6-phosphate dehydrogenase and glutamate dehydrogenase were key enzymes for differentiating all clinical and nonclinical isolates of A. fumigatus from the other Aspergillus spp. Ubiquinone systems and enzyme patterns appear to be objective and useful indicators for use in the precise identification of clinical isolates of Aspergillus spp.
EVALUATION OF METHYL ANTHRANILATE AS A BIRD REPELLENT IN FRUIT CROPS (1992)

Methyl anthranilate (MA) is a grape-flavored food additive that is aversive to birds. Previous studies had indicated that anthranilates can deter frugivorous birds but that anthranilates are phytotoxic. In this study, I tested the bird repellency to 2 MA formulations on blueberry plants in a large flight pen. Neither MA formulation protected the blueberries from damage by cedar waxwings (Bombycilla cedrorum) or European starlings (Sturnus vulgaris). The encapsulated formulation, however, was nonphytotoxic. Due to the on-going need for safe bird deterrent compounds, further development and testing of MA as a bird repellent on fruit is warranted. The most fruitful and cost-effective approach, however, might be to integrate MA use with other bird deterrent methods to lower the attractiveness of the cultivated fruit relative to available alternate foods.
A beta 1-integrin receptor for fibronectin in human kidney glomeruli. (1989)

The fibronectin receptor (FNR) is a transmembrane heterodimeric glycoprotein which shares a common beta 1-chain with several other members of the integrin family of adhesion receptors. The authors have prepared a membrane fraction of isolated human glomeruli, from which two proteins (apparent molecular weights 120 kd and 140 kd) bound to a fibronectin-column, and were selectively released by the synthetic peptide Arg-Gly-Asp-Ser. These molecules were labeled in immune overlays by an antibody raised against the FNR from human placenta that recognizes both the FNR-specific a-chain and the group-specific beta 1-integrin chain. In sections of normal human kidneys this antibody labeled predominately the mesangia and the peripheral capillary walls of glomeruli by an immunoperoxidase procedure. Quantitative immunoelectron microscopy, using an indirect immunogold procedure, revealed a preferential localization along the cell membranes of mesangial, epithelial, and endothelial cells that face the mesangial matrix or the glomerular basement membrane (GBM). In kidney biopsies from patients with various glomerular diseases (membranous and other forms of glomerulonephritis, minimal change disease) the distribution was similar to that in normal glomeruli. These findings indicate that a beta 1-integrin-related FNR is present in normal and diseased human glomeruli.
Restoration of Appressorial Penetration Ability by Melanin Precursors in <i>Pyricularia oryzae</i> Treated with Antipenetrants and in Melanin-Deficient Mutants (1987)

イネいもち病菌の付着器によるタマネギ表皮細胞への侵入能は, アルビノ株や, メラニン生合成阻害剤であるセルレニン, フサライド, トリシクラゾールで処理された野生株では欠損していた. シタロンおよび1, 8-ジヒドロキシナフタリン (1, 8-DHN) の添加によって, アルビノ株およびセルレニン処理された野生株のメラニン生成と侵入能は回復した. シタロンによる回復効果はフサライドあるいはトリシクラゾールによって打ち消されたが, 1, 8-DHNによる回復効果は妨げられなかった. フサライドあるいはトリシクラゾール0.1μg/mlで処理された野生株の侵入能は, 1, 8-DHNの添加によって回復したが, 1, 10μg/ml処理区ではセルレニンを添加しなければ, 1, 8-DHNによる回復効果は認められなかった. 以上の結果から, フサライド, トリシクラゾールによるメラニン生合成経路の阻害は二つの侵入阻害作用, (1) メラニン合成系の阻害, (2) 阻害性物質の蓄積, をもたらすことが示唆される. 後者の作用は前者に随伴して起こると推察されるが, その効果はセルレニンによって打ち消された.
Design and test results of 6.6 kV high-Tc superconducting fault current limiter (2001)

A 6.6 kV single-phase fault current limiter (FCL) using a high-Tc superconducting coil as a limiting coil was developed. The development is a preliminary step to investigate the feasibility of the FCL application for high-voltage transmission lines. The FCL is of the rectifier type and is mainly comprised of a limiting coil, a sub-cooled nitrogen cryostat with a cryocooler, and a rectifier bridge. The limiting coil, wound as a solenoid by Ag/Mn sheathed Bi-2223 tapes, has an inductance of 30 mH. It is immersed in a liquid nitrogen bath in the cryostat. A Gifford-McMahon cryocooler cools the cryogen below 77.3 K. A pressure regulator keeps the cryogen at an atmospheric pressure. The coil has a critical current of 70 A at 64 K and endures a 50 Hz overvoltage of 22 kV against the ground. In a fault current limiting test with a short-circuit generator, a short-circuit current of 12.5 kA was limited to 1.2 kA.