gebhart/patrepeval huggingface dataset:
The complex subband decomposition and its application to the decimation of large adaptive filtering problems (2002)

We show that a near perfect reconstruction (NPR) M-channel filterbank with a diagonal system inserted between the analysis and synthesis filterbanks may be used to decompose a finite impulse response (FIR) system of order L into M complex subband components, each of order L/K, where K is the downsampling rate. This decomposition is at the expense of using complex arithmetic for the subband processing. The theory surrounding the proposed filterbank structure leads to a new understanding of subbanded adaptive filtering implementations. It also leads naturally to a delayless subbanded adaptive filter scheme. Using conditions on the analysis and synthesis filters, the formulas for the subband components and their respective properties are developed. Simulation results for an acoustic echo cancellation (AEC) example are given to support the developed theory.
Aganirsen Antisense Oligonucleotide Eye Drops Inhibit Keratitis-Induced Corneal Neovascularization and Reduce Need for Transplantation (2014)

This first phase III study on a topical inhibitor of corneal angiogenesis showed that aganirsen eye drops significantly inhibited corneal neovascularization in patients with keratitis. The need for transplantation was significantly reduced in patients with viral keratitis and central neovascularization. Topical application of aganirsen was safe and well tolerated.
Research on Men and Masculinities: Some Implications of Recent Theory for Future Work (2003)

This article offers some reflections on the challenges posed by recent trends in social theory to the field of masculinity studies. The postmodern/poststructural turn in theory has led to a reappraisal of basic concepts in many fields of research and opened up new areas for investigation. The article outlines the relevance of this work for masculinity studies and draws some implications for the future development of the field. If scholars are to effectively challenge the power relations of gender, race, and sexuality, it is important that they critically examine the discursive frameworks that shape the fabrication of concepts, the definition of problems, and the formulation of research questions. The article concludes by proposing a revised and broadened agenda for research on men and masculinities, which pays greater attention to the politics of knowledge and makes greater use of historical methods to analyze power relations and the social constructions of masculine identity and the male body.
Potential anticancer agents. 16. Methotrexate analogs with a modified peptide side chain (1978)

Nine analogues of methotrexate, in which the side chain is modified by replacement of the terminal glutamyl moiety with other amino acids, were synthesized from 2,4-diamino-6-(chloromethyl)pteridine. None of these compounds exhibited significant activity against L1210.
Immunogenicity and Efficacy of a Commercial Feline Leukemia Virus Vaccine (1993)

Twenty young adult specific pathogen-free cats were randomly divided into two groups of 10 animals each. One group was vaccinated with two doses of feline leukemia virus vaccine according to the manufacturer's recommendations. All 20 cats were challenge exposed oronasally (4 times over a 1-week period), beginning 3 weeks after immunization, with a virulent subgroup A strain of FeLV (CT600-FeLV). The severity of the FeLV infection was enhanced by treating the cats with methylprednisolone acetate at the time of the last FeLV exposure. Ten of 10 nonvaccinated cats became persistently viremic compared with 0/10 of the vaccinates. ELISA antibodies to whole FeLV were present at high concentrations after immunization in all of the vaccinated cats, and there was no observable anamnestic antibody response after challenge exposure. ELISA antibodies to whole FeLV appeared at low concentrations in the serum of nonvaccinated cats after infection but disappeared as the viremia became permanently established. Virus neutralizing antibodies were detected in 3/10 vaccinates and 0/10 nonvaccinates immediately before FeLV challenge exposure, and in 8/10 vaccinates and 1/10 nonvaccinates 5 weeks later. Although vaccination did not consistently evoke virus neutralizing antibodies, it appeared to immunologically prime cats for a virus-neutralizing antibody response after infection. Active FeLV infection was detected in bone marrow cells taken 14 weeks after infection from 10/10 nonvaccinates and 0/10 vaccinates. Latent FeLV infection was not detected in bone marrow cells from any of the vaccinated cats 14 weeks after challenge exposure.
Critical aspects of [NiFe]hydrogenase ligand composition (2009)

Structural analysis of the resting state of [NiFe]hydrogenase ([NiFe]H(2)ase) shows that the active site has a characteristic bis(mu-thiolato)NiFe unit, where the Ni atom and the Fe atom are bridged by an undetermined oxygen-bearing ligand. This ligand probably derives from the aqueous solvent and is therefore most likely to be H(2)O, OH(-) or O(2-). Here, we compare the reactivities of a NiFe and a NiRu complex when bearing either acetonitrile or aqueous ligands and demonstrate the critical role of an aqueous ligand in hydrogenase and its mimics. We also make observations on the necessity of organometallic metal-carbon bonds to the supporting frameworks.
Self-assembly templates by selective plasma surface modification of micropatterned photoresist (2003)

Self-assembly templates, consisting of micropatterned hydrophobic and hydrophilic regions, are fabricated using a plasma surface modification technique. With exposure to O/sub 2/ plasma, photoresist, silicon, and glass can be modified to hydrophilic surfaces. When followed by SF/sub 6/ or CF/sub 4/ plasma, the photoresist surface can be modified to hydrophobic while silicon and glass surfaces are not affected. The difference in surface energy between the hydrophilic and hydrophobic regions is large, as indicated by the differential contact angle of 120/spl deg/ between the two regions for wetting with water. Photonic crystals are made from colloidal solutions and protein patterning is demonstrated using self-assembly templates made by selective plasma surface modification. The maximized surface energy difference between substrate and template patterning allows ideal self-assembly of photonic crystals and selective attachment of proteins.
Studies in the replication of viral RNA (1967)

Experiments will be described which demonstrate that the product of purified “Qβ-replicase” is fully competent to serve both as a template and as a program for the synthesis of complete virus particles. The use of mutant RNA has permitted the demonstration that nucleic acid is the instructive agent in the replication process and hence satisfies the definition of a self-duplicating entity. Methods have been devised to examine the product both physically and biologically with a minimum of manipulation and with complete recovery of product and input template. A detailed analysis of every interval of synthesis has thus become possible. These technical advances have permitted us to demonstrate the existence of a latent period prior to the appearance of the first new complete infectious RNA molecules. Further, this latent period is accompanied by an eclipse of the input templates as infectious agents. The use of electrophoretic separation on acrylamide gels has yielded a detailed account of both templates and early product during the latent period, with the consequent identification of the intermediate stages. The resulting data and their implications for the mechanism of RNA replication will be discussed.
Rivoglitazone: A New Thiazolidinedione for the Treatment of Type 2 Diabetes Mellitus (2013)

Rivoglitazone is the fourth agent in the thiazolidinedione class of antidiabetes drugs. Although rivoglitazone appears to be more potent in its ability to lower A1C levels compared with other thiazolidinediones, further studies of longer duration are needed to fully assess the risks associated with this drug. Until these can be completed, we cannot recommend rivoglitazone over currently approved drugs in this class.
Bromination of 3-methoxyfluoranthene (1969)

Bromination of 3-methoxyfluoranthene in acetic acid yields 2,8-dibromo-3-methoxyfluoranthene, the structure of which follows from its oxidation to 6-bromo-9-oxofluorene-1-carboxylic acid, and synthesis from 3-bromo-fluorene-9-carboxylic acid. 8-Bromo-3-methoxy- and 8-bromo-3-methoxy-2-nitro-fluoranthene have been prepared. Unsuccessful attempts to synthesise 2-bromo-3-methoxyfluoranthene are described.
Differential activation of CREB by Ca2+/calmodulin-dependent protein kinases type II and type IV involves phosphorylation of a site that negatively regulates activity. (1994)

The cAMP response element-binding protein (CREB) has been shown to mediate transcriptional activation of genes in response to both cAMP and calcium influx signal transduction pathways. The roles of two multifunctional calcium/calmodulin-dependent protein kinases, CaMKIV and CaMKII, were examined in transient transfection studies that utilized either the full-length or the constitutively active forms of these kinases. The results indicate that CaMKIV is much more potent than CaMKII in activating CREB in three different cell lines. It was also found in these studies that Ser133 of CREB is essential for its activation by CaMKIV. Because both CaMKII and CaMKIV can phosphorylate CREB, we pursued further the mechanism by which CaMKII and CaMKIV differentially regulate CREB activity. Mutagenesis studies and phosphopeptide mapping analysis demonstrated that in vitro, CaMKIV phosphorylates CREB at Ser133 only, whereas CaMKII phosphorylates CREB at Ser133 and a second site, Ser142. Transient transfection studies revealed that phosphorylation of Ser142 by CaMKII blocks the activation of CREB that would otherwise occur when Ser133 is phosphorylated. When Ser142 was mutated to alanine, CREB was activated by CaMKII, as well as by CaMKIV. Furthermore, mutation of Ser142 to alanine enhanced the ability of Ca2+ influx to activate CREB, suggesting a physiological role for the phosphorylation of Ser142 in modulation of CREB activity. These data provide evidence for a new mechanism for regulation of CREB activity involving phosphorylation of a negative regulatory site in the transcriptional activation domain. The studies also provide new insights into possible interactions between the cAMP and Ca2+ signaling pathways in the regulation of transcription. In particular, changes in intracellular Ca2+ have the potential to either inhibit or augment the ability of cAMP to stimulate transcription, depending on the presence of specific forms of Ca2+/calmodulin-dependent protein kinases.
Bayesian integrated functional analysis of microarray data (2004)

Here we show that, by an application of hierarchical Bayesian methodology, this sequential procedure can be replaced by a single joint analysis, while systematically accounting for the uncertainties in this process. Moreover, we can also integrate relevant functional information available from databases into such an analysis, thereby increasing the reliability of the biological conclusions that are drawn. We illustrate these points by analysing real data and by showing that the genes can be divided into categories of interest, with the defining characteristic depending on the biological question that is considered. We contend that the proposed method has advantages at two levels. First, there are gains in the statistical and biological results from the analysis of this particular dataset. Second, it opens up new possibilities in analysing microarray data in general.
P[acman]: A BAC Transgenic Platform for Targeted Insertion of Large DNA Fragments in <i>D. melanogaster</i> (2006)

We describe a transgenesis platform for Drosophila melanogaster that integrates three recently developed technologies: a conditionally amplifiable bacterial artificial chromosome (BAC), recombineering, and bacteriophage PhiC31-mediated transgenesis. The BAC is maintained at low copy number, facilitating plasmid maintenance and recombineering, but is induced to high copy number for plasmid isolation. Recombineering allows gap repair and mutagenesis in bacteria. Gap repair efficiently retrieves DNA fragments up to 133 kilobases long from P1 or BAC clones. PhiC31-mediated transgenesis integrates these large DNA fragments at specific sites in the genome, allowing the rescue of lethal mutations in the corresponding genes. This transgenesis platform should greatly facilitate structure/function analyses of most Drosophila genes.
REVIEWS (1999)

Journal Article REVIEWS Get access J R WATSONThe English Hymn A Critical and Historical Study Pp x+552Oxford Clarendon Press, 1997 £65 ISABEL RIVERS ISABEL RIVERS St Hugh's College Oxford Search for other works by this author on: Oxford Academic Google Scholar The Review of English Studies, Volume 50, Issue 197, February 1999, Pages 104–105, https://doi.org/10.1093/res/50.197.104 Published: 01 February 1999
Nonaromatic Polyimides Derived from Cycloaliphatic Monomers (1999)

A novel tetracarboxylic dianhydride bearing a cycloaliphatic structure, (4arH,8acH)-decahydro-1t,4t:5c,8c-dimethanonaphthalene-2c,3c,6c,7c-tetracarboxylic 2,3:6,7-dianhydride (DNDA), was synthesized, and its structure was determined using X-ray crystallographic analysis. Polycondensation of DNDA or bicyclo[2.2.1]heptane-2-endo,3-endo,5-exo,6-exo-tetracarboxylic 2,3:5,6-dianhydride (BHDA) with a cycloaliphatic diamine, bis(aminomethyl)bicyclo[2.2.1]heptane (BBH) was carried out in HMPA. A viscous poly(amic acid) solution was obtained only when BBH was slowly added to the HMPA solution of the dianhydride, whereas the reverse adding order of the monomers resulted in precipitation due to salt formation. The poly(amic acid) solutions afforded nonaromatic polyimides as flexible and free-standing films after being cast and cured. The polyimide films were soluble in organic solvents such as DMAc and were colorless with a cutoff at wavelength shorter than 235 nm. The average refractive index of the BHDA−BBH polyimide film was 1.522, and the optical anisotropy, the difference between in-plane and out-of-plane indices, was nearly zero. The dielectric constant that was estimated from the refractive index according to the modified Maxwell equation was 2.55. The polyimides have good thermal stability with the 5% weight-loss temperatures around 450 °C. The polyimide films exhibit higher Tg's over 290 °C. The high-temperature stability may be caused by the introduction of polyalicyclic structures, which results in an increase in the polymer main chain rigidity and less probability of main-chain scission.
A Virtual Reality-based Surgical Simulation System for Virtual Neuroendoscopy (2007)

Virtual reality technology has great potential benefit to practice of neurosurgery. Neurosurgery is a discipline of medicine and that specialty of surgery which provides the operative and non-operative management (i.e., prevention, diagnosis, evaluation, treatment, critical care, and rehabilitation) of disorders of the central, peripheral, and autonomic nervous systems, including their supporting structures and vascular supply. In this paper, we propose a neurosurgical simulation system which integrates the virtual reality technology and medicine. Using the slices of human brain scanning images, we reconstruct 3-dimensional virtual objects which closely resemble actual brain structures. This allows users to navigate inside the virtual ventricle in a realistic manner. By incorporating with intuitive graphical user interface, simulated graphics of endoscopic movement can convey a realistic response to user for medical training.
There is Value in Operational Flexibility: An Intelligent Well Application (2003)

Abstract Intelligent well completion technology provides a broad spectrum of value generating functionality for oil and gas field operations, all derived from the ability to monitor and control fluid production and injection by zone in real-time. A major barrier to intelligent well technology adoption has been the lack of method to quantitatively define the value associated with various applications of the technology. Most companies often use a Net Present Value (NPV) analysis to quantify and rank project proposals. Due to the nature of intelligent well technology, NPV analysis is not applicable to a wide range of applications and invariably underestimates the value associated with the technology. Operators intuitively understand the benefits of the technology, but are unable to represent it with conventional NPV valuation techniques, and thus are unable to justify intelligent well completion deployment against more conventional, better-understood, but lower valued, completion technology. An approach has been developed to define and solve the intelligent well valuation problem using mathematical techniques from the financial community called Real Options analysis, specifically, the concept of Flexibility Options. It quantifies the option value derived from the flexibility offered by the application of intelligent well technology enabling the ability to monitor and respond to reservoir uncertainties as it is manifested throughout the field life cycle. Case study has been developed using well data from field in the Gulf of Mexico region incorporating the level of smartness, the associated system reliability, and the projected reservoir performances to quantify the flexibility option value offered through the implementation of intelligent well over conventional completion technology. This paper will support the conclusions that application of field proven intelligent well technology can increase asset value. The case study use intelligent well critical variables to quantify the value of operating flexibility derived from implementing intelligent well technology. However, some important points should be considered. Firstly, equipment reliability is vital in the valuation. Secondly, economic justification including option value is required to assess the business case in face of reservoir uncertainties. Thirdly, the relationship between resolving reservoir uncertainty, system reliability and functionality must be understood to realize "The right level of Smartness…"
Management of Type a Supracondylar Fractures Of Femur with Dynamic Condylar Screw (Dcs) (2012)

Introduction: Supracondylar fractures of the femur in adults are relatively uncommon and account for only 7% of all femoral fractures 1 . However these fractures are often complex injuries, that present with numerous complications, like mal alignment, flexion contractures, stiffness and limb length discrepancies Material and methods:. This study was based on 30 patients of fresh supracondylar fractures of the femur treated with dynamic condylar screw at tertiary Trauma Center.. The patients were followed up for 1 year and parameters like union, range of movements and time for healing were recorded. Schatzker and Lambert Criteria (Annexure I) were used to grade the results. Results: The age range was from 18 years to 72 years. 18 patients were male and 12 were female. The cause of injury was high energy trauma like road traffic accidents and fall from height. All fractures were of AO type A. Based on above mentioned criteria, results were excellent in 18 patients (60%), good in 6 patients (20%), fair in 5 patients (17%) and poor in 1 patient (3%). Conclusion: Dynamic condylar screw is one of the best devices to treat supracondylar fractures of the femur.
Live URLs (2006)

This paper provides a novel approach to use URI fragment identifiers to enable HTTP clients to address and process content, independent of its original representation.
Locating perceptually salient points on planar curves (1994)

This paper describes the underlying ideas and algorithmic details of a computer program that performs at a human level of competence for a significant subset of the curve partitioning task. It extends and rounds out the technique and philosophical approach originally presented by Fischler and Bolles (1986). In particular, it provides a unified strategy for selecting and dealing with interactions between salient points, even when these points are salient at different scales of resolution. Experimental results are presented involving on the order of 1000 real and synthetically generated images.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Proposal to stabilize and detect half-quantum vortices in strontium ruthenate thin films: Non-Abelian braiding statistics of vortices in a<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mi>p</mml:mi><mml:mi>x</mml:mi></mml:msub><mml:mo>+</mml:mo><mml:mi>i</mml:mi><mml:msub><mml:mi>p</mml:mi><mml:mi>y</mml:mi></mml:msub></mml:mrow></mml:math>superconductor (2006)

We propose a simple way to stabilize half-quantum vortices in superconducting strontium ruthenate, assuming the order parameter is of chiral ${p}_{x}+i{p}_{y}$ symmetry, as is suggested by recent experiments. The method, first given by Salomaa and Volovik in the context of Helium-3, is very naturally suited for strontium ruthenate, which has a layered, quasi-two-dimensional, perovskite crystal structure. We propose possible experiments to detect their non-Abelian braiding statistics. These experiments are of potential importance for topological quantum computation.
Drug-induced haploinsufficiency of fission yeast provides a powerful tool for identification of drug targets (2003)

Genome-wide systematic deletion mutants were generated using a PCR-based targeted mutagenesis of Schizosaccharomyces pombe. In a drug-sensitivity assay using thiabendazole (TBZ), an inhibitor of microtubule assembly, a heterozygous nda2 mutant (nda2+/nda2-), deleting one copy of nda2 encoding the microtubule subunit alpha 1 demonstrated a distinct sensitivity to TBZ, indicating TBZ-induced haploinsufficiency. This result suggests that profiling drug-induced haploinsufficiency can be exploited to identify target genes for drugs and discover new drugs.
Computer simulation of aqueous block copolymer assemblies: Length scales and methods (2006)

Abstract Atomistic, coarse‐grain, and mesoscopic computer simulation methods applied recently to the study of block copolymer assemblies in solution are reviewed. At the atomic level, particle‐based simulations have provided insight into specific interactions such as hydrogen bonding between polymer and water. Coarse‐grain models have given a generalized view of the conformations of polymer chains in solvents of different qualities by grouping clusters of atoms into effective interaction sites. Mesoscopic self‐consistent field theory allows for the study of the phase diagram of block copolymers in water using a mean‐field continuum description. Advances in and results with these methodologies are presented along with present challenges. © 2006 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 44: 1907–1918, 2006
High-speed high-resolution coherent optical modulator (1983)

A new design has been developed for an optical intensity-to-phase modulator suitable for ail-coherent and incoherent-to-coherent optical modulation. For applications such as real-time optical control and real-time erasable holography, high-speed resolution and optical quality are required. High sensitivity and diffraction efficiency also are desirable. For high speed the device must work by the Pockels, Kerr, or Faraday effect. The Pockels effect was selected because large phase shifts are easily generated. The modulator then required an input detector for photon-to-charge conversion. The design considers the properties of the Pockels cell crystal, the detector, and the electrical-optical interfaces and coatings.