gebhart/patrepeval huggingface dataset:
Accelerating on-line training of LS-SVM with run-time reconfiguration (2011)

Least Squares Support Vector Machines(LS-SVM), which is an efficient supervised learning tool, has been widely applied to real-time on-line data processing in many fields. However, the on-line training of LS-SVM always suffers from huge computation which greatly limits its practicability especially in embedded systems. By leveraging the flexibility and high degree parallelism offered by reconfigurable fabrics, we propose a Run-Time Reconfiguration(RTR) framework to accelerate the on-line training of LS-SVM. To realize maximum computational parallelism, we divide the training process into two parts, the kernel matrix formulation and the least-square problem solving. We dynamically load these two parts into FPGA with RTR under the control of the embedded PowerPC. In the kernel matrix formulation part, we design a piecewise linear interpolation method to realize the radial basis function. In the least-square problem solving part, the modified Cholesky Decomposition is introduced to avoid the latency caused by square roots operations. The whole design is tested on Virtex XC5VFX130T with a 150MHz clock. The experiments show appealing speed up which ranges from 6~218× over a Xeon CPU implementation on five different sized datasets. From time cost percentage analysis, our proposed architecture can be effectively applied to LS-SVM training in more than 1000 samples applications.
Contact nucleation of various crystal types (1975)

Abstract The purpose of this study was to investigate contact nucleation for various types of crystalline materials. Selected were aqueous solutions of two hydrated inorganic salts (MgSO 4 · 7H 2 O and KAl(SO 4 ) 2 · 12H 2 O), one nonhydrated inorganic salt (K 2 SO 4 ) and one organic substance (citric acid). Nucleation data were determined as number of nuclei generated per contact as a function of supersaturation and impact energy. Both of these variables strongly influenced the number of nuclei generated per contact. These data show that crystal growth and contact nucleation are related, with more rapidly growing substances giving higher yields of nuclei.
Lipase-catalyzed Approaches towards Secondary Alcohols: Intermediates for Enantiopure Drugs (2010)

The use of enantiopure intermediates for drug synthesis is a trend in pharmaceutical industry. Different physiological effects are associated with the enantiomers of chiral molecules. Thus, the safety profile of a drug based on an enantiopure active pharmaceutical ingredient is more reliable. Biocatalysis is an important tool to access enantiopure molecules. In biocatalysis, the advantage of selectivity (chemo-, regio- and stereoselectivity) is combined with the benefits of a green synthesis strategy. Chemoenzymatic syntheses of drug molecules, obtained by combining biocatalysis with modern chemical synthesis steps usually consists of fewer reaction steps, reduced waste production and improved overall synthetic efficiency both in yields and enantio- and/or diastereoselectivities compared with classical chemical synthesis.\n\nThe experimental work together with the literature review clearly indicates that lipase catalysis is highly applicable in the synthesis of enantiopure intermediates of drug molecules as the basis to infer the correct stereochemistry. By lipase catalysis, enantiopure secondary alcohols used as intermediates in the synthesis of Dorzolamide, an antiglaucoma drug, were obtained. Enantiopure _-hydroxy nitriles as potential intermediates for the synthesis of antidepressant drugs with 1-aryl-3- methylaminopropan-1-ol structure were also obtained with lipases. Kinetic resolution of racemates was the main biocatalytic approach applied. <i>Candida Antarctica</i> lipase B, <i>Burkholderia cepacia</i> lipase and <i> Thermomyces lanuginosus</i> lipase were applied for the acylation of alcohols and the alcoholysis of their esters in organic solvents, such as in diisopropyl ether and <i>tert-</i>butyl methyl ether. <i>Candida Antarctica</i> lipase B was used under solvent free conditions for the acylation of ethyl 3-hydroxybutanoate.
The Synthesis and Characterization of Poly Vinyl Chloride Chemically Modified with C<sub>60</sub> (2008)

Abstract The fullerenated poly vinyl chloride was synthesized by the addition reaction of azido‐substituted poly vinyl chloride with C60. Structural characterization carried out using Raman and FTIR spectroscopy confirm the presence of C60 chemically bound in the new compound. Also, the photoluminescence properties of fullerenated poly vinyl chloride are considerably changed from those of C60
Asymmetric Synthesis of <i>iso</i>-Boc (<i>S</i>)-2-Amino-8-nonenoic Acid in One Through-Process (2015)

A practical through-process to prepare iso-Boc (S)-2-amino-8-nonenoic acid has been developed. The short synthesis utilizes a highly enantioselective, enzymatic reductive amination of an α-keto acid substrate, which is prepared via a Grignard addition to diethyl oxalate. Starting from 7-bromohept-1-ene and without isolation of any intermediates, iso-Boc (S)-2-amino-8-nonenoic acid is prepared in 60% overall yield and >99.9% ee.
Induction of potent NK cell-dependent anti-myeloma cytotoxic T cells in response to combined mapatumumab and bortezomib (2015)

There is increasing evidence that some cancer therapies can promote tumor immunogenicity to boost the endogenous antitumor immune response. In this study, we used the novel combination of agonistic anti-TRAIL-R1 antibody (mapatumumab, Mapa) with low dose bortezomib (LDB) for this purpose. The combination induced profound myeloma cell apoptosis, greatly enhanced the uptake of myeloma cell apoptotic bodies by dendritic cell (DC) and induced anti-myeloma cytotoxicity by both CD8<sup>+</sup> T cells and NK cells. Cytotoxic lymphocyte expansion was detected within 24 h of commencing therapy and was maximized when myeloma-pulsed DC were co-treated with low dose bortezomib and mapatumumab (LDB+Mapa) in the presence of NK cells. This study shows that Mapa has two distinct but connected modes of action against multiple myeloma (MM). First, when combined with LDB, Mapa produced powerful myeloma cell apoptosis; secondly, it promoted DC priming and an NK cell-mediated expansion of anti-myeloma cytotoxic lymphocyte (CTL). Overall, this study indicates that Mapa can be used to drive potent anti-MM immune responses.
<title>Cost-effective mask fabrication on Kapton membrane for deep x-ray lithography</title> (1997)

A low-cost mask fabrication process for deep x-ray lithography is described. The mask consists of Kapton films stretched on a ring with absorber structures formed by optical lithography using NFR015 resist and gold electroplating, similar to the masks from the 'early x-ray lithography age'. Such masks proved easy to fabricate and are presently being evaluated for deep x-ray lithography applications. First experiments indicate that they exhibit sufficient radiation resistance and limited variational dimensional changes during exposure at 1.3-1.5 GeV on the XRLM3 beamline at CAMD.
Fast Separations at Elevated Temperatures on Polybutadiene-Coated Zirconia Reversed-Phase Material (1997)

This paper describes the results of thermal stability studies of polybutadiene-coated zirconia reversed phases and application to fast HPLC separations at elevated temperatures and high flow rates. The thermal stability of the material was evaluated at temperatures up to 200 degrees C, and the rapid analyses of polyaromatic hydrocarbons and typical reversed-phase test mixtures were carried out at 100 degrees C and a flow rate of 5 mL/min. We found that the material is completely stable at 200 degrees C for at least 1300 column volumes. Analysis time can be decreased about 18-fold at high temperatures and flow rates without any significant loss in resolution relative to that at conventional temperatures and normal flow rates. For the separation of a five-component reversed-phase test mixture, the analysis time was only 50 s.
Introducing the 'Narrative Construal of Reality' and the 'Club of Life' (2008)

This paper outlines two exercises that were used to train a wide variety of staff members in a multi-service organisation for homeless young people. The training exercises present novel approaches to introducing the concepts of the narrative construal of reality, dominant and subordinate stories, re-membering conversations, and the idea of identity as made up of a 'club of life'.
Detection of epileptic-seizures by means of power spectrum analysis of heart rate variability: A pilot study (2010)

Specifically high reciprocal HF-power peaks suggest suppressed parasympathetic activity just around seizure-onset time. Seizure detection using HRV-analysis seems to be a promising method for non-invasive seizure detection in the early phase of the clinical event (even preceding the onset).
La guarda y custodia compartida: una solución deseable (2017)

espanolLa Ley 15/2005, de 8 de julio, modifico el articulo 92 del Codigo Civil introduciendo en nuestro ordenamiento juridico la posibilidad de que el Juez, en los casos de crisis de parejas matrimoniales o extramatrimoniales, en las que existan hijos menores de edad, acuerde la guarda y custodia compartida de estos por ambos progenitores. La doctrina del TS en relacion con la interpretacion del mentado precepto, y los criterios que hay que valorar a la hora de acordar dicha medida, en el supuesto en el que no sea solicitada de comun acuerdo entre las partes, han sido fijados en la Sentencia de dicho Tribunal 259/2013, de 29 de abril. En el presente articulo se analizara la doctrina de TS sobre la procedencia de la adopcion de la guarda y custodia compartida, lo criterios fijados por la Jurisprudencia de dicho Tribunal en relacion con la misma, y como se estan aplicando por la jurisprudencia menor. EnglishAct 15/2005, of 8 July, amended Section 92 of the Civil Code, introducing in our legal system the possibility that the judge, in cases of crisis of marital or extramarital couples in which there are minor children, agree to the guardianship and custody of these children by both parents. The doctrine of the Tribunal Supremo (Supreme Court) in relation to the interpretation of the quoted provision, and the criteria that need to be assessed when agreeing on such a measure, in the assumption when it is not requested by mutual agreement between the parties, have been laid down in the judgement 259/2013, of 29 April, of that Court. In this article, we will analyse the doctrine of Tribunal Supremo on the origin of the adoption of the joint-custody, the criteria laid down by the case law of that Court on that matter, and how those criteria are being implemented by the minor case law.
CAR T Cells Targeting Podoplanin Reduce Orthotopic Glioblastomas in Mouse Brains (2016)

Glioblastoma (GBM) is the most common and lethal primary malignant brain tumor in adults with a 5-year overall survival rate of less than 10%. Podoplanin (PDPN) is a type I transmembrane mucin-like glycoprotein, expressed in the lymphatic endothelium. Several solid tumors overexpress PDPN, including the mesenchymal type of GBM, which has been reported to present the worst prognosis among GBM subtypes. Chimeric antigen receptor (CAR)-transduced T cells can recognize predefined tumor surface antigens independent of MHC restriction, which is often downregulated in gliomas. We constructed a lentiviral vector expressing a third-generation CAR comprising a PDPN-specific antibody (NZ-1-based single-chain variable fragment) with CD28, 4-1BB, and CD3ζ intracellular domains. CAR-transduced peripheral blood monocytes were immunologically evaluated by calcein-mediated cytotoxic assay, ELISA, tumor size, and overall survival. The generated CAR T cells were specific and effective against PDPN-positive GBM cells in vitro. Systemic injection of the CAR T cells into an immunodeficient mouse model inhibited the growth of intracranial glioma xenografts in vivo. CAR T-cell therapy that targets PDPN would be a promising adoptive immunotherapy to treat mesenchymal GBM.
Chemical Vapor Deposition of Aluminum Enhanced by Magnetron‐Plasma (1988)

The authors have developed a new deposition system, magnetron‐plasma CVD (MPCVD), allowing the practical application of metal organic CVD of Al films. With this system, it has been found that the plasma chemical reaction is confined to the surface region of the substrate by an applied planar magnetic field. The fundamental parameters for the MPCVD and the characterization of deposited Al film were investigated. The low temperature deposition was performed below 100°C. A hillock‐free Al film with a resistivity of was obtained.
Amphetamine, mazindol, and fencamfamin in narcolepsy. (1985)

Twenty patients with the narcoleptic syndrome were treated separately with dexamphetamine sulphate tablets 10 and 30 mg, Dexedrine Spansules 10 mg, mazindol 4 mg, and fencamfamin hydrochloride 60 mg daily. Each drug was given for four weeks and the effects compared. In these dosages the reported frequency of attacks of narcolepsy was roughly halved with each treatment, dexamphetamine 30 mg daily being only slightly more potent than 10 mg. The subjective effects of Dexedrine tablets and Spansules could not be distinguished by most patients. Effects on mood, alertness, and sympathomimetic side effects were largely inseparable with all these drugs, but a decrease in appetite was not reported by patients with narcolepsy.
Guidance Values for Surface Monitoring of Antineoplastic Drugs in German Pharmacies (2009)

The introduction of TGVs helps to reduce occupational exposure and allows pharmacy personnel to benchmark their own contamination levels. This provides a basis for improvement in occupational safety precautions and for regular contamination controls.
NKG2D Ligand MICA Is Retained in the<i>cis</i>-Golgi Apparatus by Human Cytomegalovirus Protein UL142 (2009)

Human cytomegalovirus (HCMV) evades T-cell recognition by down-regulating expression of major histocompatibility complex (MHC) class I and II molecules on the surfaces of infected cells. Contrary to the "missing-self" hypothesis, HCMV-infected cells are refractory to lysis by natural killer (NK) cells. Inhibition of NK cell function is mediated by a number of HCMV immune evasion molecules, which operate by delivering inhibitory signals to NK cells and preventing engagement of activating ligands. One such molecule is UL142, which is an MHC class I-related glycoprotein encoded by clinical isolates and low-passage-number strains of HCMV. UL142 is known to down-modulate surface expression of MHC class I-related chain A (MICA), which is a ligand of the activating NK receptor NKG2D. However, the mechanism by which UL142 interferes with MICA is unknown. Here, we show that UL142 localizes predominantly to the endoplasmic reticulum (ER) and cis-Golgi apparatus. The transmembrane domain of UL142 mediates its ER localization, while we propose that the UL142 luminal domain is involved in its cis-Golgi localization. We also confirm that UL142 down-modulates surface expression of full-length MICA alleles while having no effect on the truncated allele MICA*008. However, we demonstrate for the first time that UL142 retains full-length MICA alleles in the cis-Golgi apparatus. In addition, we propose that UL142 interacts with nascent MICA en route to the cell surface but not mature MICA at the cell surface. Our data also demonstrate that the UL142 luminal and transmembrane domains are involved in recognition and intracellular sequestration of full-length MICA alleles.
Observation of Magnetic Fields Generated by Tsunamis (2011)

Tsunamis produce perturbations in the Earth's magnetic field by electromagnetic induction. Recent deployments of highly accurate magnetometers and the exceptionally deep solar minimum provided ideal conditions to observe these small signals from the tsunami resulting from the strong Chilean earthquake on 27 February 2010. Magnetic observatory measurements on Easter Island, 3500 kilometers west of the epicenter, show a periodic signal of 1 nanotesla, coincident in time with recordings from the local tide gauge. The detection of these magnetic signals represents a milestone in understanding tsunami‐induced electromagnetic effects.
Imatinib pharmacokinetics and its correlation with response and safety in chronic-phase chronic myeloid leukemia: a subanalysis of the IRIS study (2008)

Imatinib at 400 mg daily is standard treatment for chronic myeloid leukemia in chronic phase. We here describe the correlation of imatinib trough plasma concentrations (C(mins)) with clinical responses, event-free survival (EFS), and adverse events (AEs). Trough level plasma samples were obtained on day 29 (steady state, n = 351). Plasma concentrations of imatinib and its metabolite CGP74588 were determined by liquid chromatography/mass spectrometry. The overall mean (+/- SD, CV%) steady-state C(min) for imatinib and CGP74588 were 979 ng/mL (+/- 530 ng/mL, 54.1%) and 242 ng/mL (+/- 106 ng/mL, 43.6%), respectively. Cumulative estimated complete cytogenetic response (CCyR) and major molecular response (MMR) rates differed among the quartiles of imatinib trough levels (P = .01 for CCyR, P = .02 for MMR). C(min) of imatinib was significantly higher in patients who achieved CCyR (1009 +/- 544 ng/mL vs 812 +/- 409 ng/mL, P = .01). Patients with high imatinib exposure had better rates of CCyR and MMR and EFS. An exploratory analysis demonstrated that imatinib trough levels were predictive of higher CCyR independently of Sokal risk group. AE rates were similar among the imatinib quartile categories except fluid retention, rash, myalgia, and anemia, which were more common at higher imatinib concentrations. These results suggest that an adequate plasma concentration of imatinib is important for a good clinical response. This study is registered at http://clinicaltrials.gov as NCT00333840.
<sup>13</sup>C NMR spectral data of some <i>N</i>‐vanillyl‐, <i>N</i>‐piperonyl‐ and <i>N</i>‐veratryl‐alkylaminoalkylamides (1987)

Abstract 13 C NMR spectra for 66 N ‐vanillyl‐and‐piperonyl‐ and N ‐veratryl‐chloralkyl‐and‐alkylaminoalkyl‐amides are reported. Relative substituent effects are discussed.
Bibliography: International Negotiable Instruments (1979)

Bibliography: International Negotiable Instruments Get access The American Journal of Comparative Law, Volume 27, Issue 2-3, Summer 1979, Pages 562–563, https://doi.org/10.2307/840055 Published: 01 May 1979
Leaky lens based UWB focal plane arrays for Sub-mm wave imaging based on kinetic inductance detectors (2008)

A novel strategy for broad band focal plane array design is proposed. Its purpose is to couple the radiation from a Large F/D reflector system to an array of Kinetic Inductance detectors that are being investigated and realized at SRON. To maximize the benefits from using their BW properties the idea is to use Leaky Lens based array elements, as imaging pixels.
Residual migration; applications and limitations (1985)

Abstract The correct migration of seismic data depends on the accuracy of the chosen velocity model. Rocca and Salvador (1982) showed that small errors in the velocity model may be efficiently corrected by applying a residual migration to previously migrated data, rather than remigrating the original data with a corrected velocity field. The effective velocity used in this residual processing is usually small compared to the original migration velocity. This decreases computational cost relative to a full migration, and allows the initial migration to be done with a less accurate but faster algorithm than would otherwise be required. The possible advantages are many. The overall cost of migration may be reduced, a consideration especially important when migrating 3-D data sets. Migration quality may be improved, because the location of mispositioned reflectors can be corrected and because of the freedom to choose initial migration with a high dip, low dispersion method such as Stolt migration. Interactive residual sharpening of the migrated image also becomes feasible. We discuss the theoretical and practical limitations of residual migration and quantify the related reductions of effective dip, velocity, and frequency after initial migration. We determine how accurate the initial migration velocity must be to justify use of this approach and analyze aliasing and numerical artifacts. Field data examples using Kirchhoff summation and finite-difference migration illustrate the features and drawbacks of the method.
Design and characteristics of a new magnetic worm gear using permanent magnet (1993)

The structure and the method of design of a magnetic worm gear using a permanent magnet are described. The basic concept of the design is as follows: high gear ratio; and meshing based on internal contact to enlarge the meshing area and reduce the size of the gear. The trial magnetic worm gear has a gear ratio of 1:33. The measured maximum transmitted torque is 11.5 Nm.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Effects of Aspirin on Embolization in an Arterial Model of Laser-Induced Thrombus Formation (1993)

This model of arterial thrombosis induced by laser was used to evaluate the effect of aspirin (Aspegic) on embolization. A partial occlusion was induced in small mesenteric arterioles (diameter 35-40 microns) with an Argon Laser. The laser induced the formation of a vessel wall lesion with damage of endothelial cells. Thrombus formed within seconds after the laser lesion and grew rapidly. Embolization began within the minute following the laser flash. Thrombus formation and embolization were repetitive phenomena. The duration of embolization was 6.50 +/- 0.84 min in the control group. Then the thrombus became stable and partially obstructed the vessel lumen. The administration of aspirin at three doses (50, 100, 200 mg/kg) by intramuscular injection, 15 min before the laser injury, induced three different phenomena: (1) an increase of the number of laser injuries required for the thrombus formation; (2) a dose-dependent decrease in the duration of embolization, and (3) a dose-dependent decrease in the number of emboli. The highest dose injected induced the strongest reduction in the duration of embolization and the number of emboli.
Divide-and-conquer: a scheme for IPv6 address longest prefix matching (2006)

Longest prefix matching (LPM) is a challenging subject because of the increasing routing table size, the increasing link speed, and the increasing Internet traffic with decreasing packet size. With the advent of IPv6, it requires reconsideration of the previous schemes particularly designed for IPv4. We introduce the first algorithm that we are aware of to employ divide-and-conquer method for IPv6 address 128-bit-long LPM. The algorithm divides an IPv6 address into 8 chunks of 16 bits each and the chunks are reduced recursively through several tunable phases according to the tradeoff between lookup performance and memory consumption. After exhaustive examination of IPv6 address allocation policies and 6 latest global backbone IPv6 BGP routing tables, we put forward some refinements to the basic scheme. The scheme is suitable for both software and hardware implementation. In measurements performed on a 1.1 GHz AMD Athlon machine using the real world IPv6 BGP routing tables, we can forward over several million IPv6 packets per second. When implemented in hardware adopting parallel chunk lookup and pipeline phase lookup architecture, the proposed scheme can achieve one IPv6 LPM lookup per memory access