gebhart/patrepeval huggingface dataset:
<i>In vivo</i> bioluminescent imaging of α‐fetoprotein‐producing hepatocellular carcinoma in the diethylnitrosamine‐treated mouse using recombinant adenoviral vector (2012)

The recombinant adenovirus vector system can be used to monitor spontaneously developing AFP-producing HCC and to evaluate targeted gene expression in tumors by in vivo BLI in a small animal model.
Paramagnetic cobalt(III) complexes of polyanionic chelating ligands (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTParamagnetic cobalt(III) complexes of polyanionic chelating ligandsTerrence J. Collins, Thomas G. Richmond, Bernard D. Santarsiero, and Brian G. R. T. TrecoCite this: J. Am. Chem. Soc. 1986, 108, 8, 2088–2090Publication Date (Print):April 1, 1986Publication History Published online1 May 2002Published inissue 1 April 1986https://pubs.acs.org/doi/10.1021/ja00268a058https://doi.org/10.1021/ja00268a058research-articleACS PublicationsRequest reuse permissionsArticle Views631Altmetric-Citations61LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
APIS: accurate prediction of hot spots in protein interfaces by combining protrusion index with solvent accessibility (2010)

We have developed an accurate prediction model for hot spot residues, given the structure of a protein complex. A major contribution of this study is to propose several new features based on the protrusion index of amino acid residues, which has been shown to significantly improve the prediction performance of hot spots. Moreover, we identify a compact and useful feature subset that has an important implication for identifying hot spot residues. Our results indicate that these features are more effective than the conventional evolutionary conservation, pairwise residue potentials and other traditional features considered previously, and that the combination of our and traditional features may support the creation of a discriminative feature set for efficient prediction of hot spot residues. The data and source code are available on web site http://home.ustc.edu.cn/~jfxia/hotspot.html.
A waveguide-based two-step approach for measuring complex permittivity tensor of uniaxial composite materials (2006)

A rectangular waveguide-based two-step approach for measuring the complex permittivity tensor of uniaxial highly lossy nonmagnetic composite materials in the S-band is presented. In the proposed scheme, two independent sets of reflection and transmission coefficient data for each material-under-test (MUT) are measured by aligning the electric field vector of the dominant TE/sub 10/ mode in the rectangular waveguide parallel and perpendicular to the fiber orientation of the uniaxial sample, respectively. The complex permittivity tensor of the MUT is determined from these measured scattering data in two successive steps. The first step uses the newly proposed analytical approach, which can resolve the ambiguity problem, commonly encountered with samples of electrical length larger than a wavelength. In the second step, nonlinear least square optimization algorithms are employed, where the material parameters using the first step are now used as the initial guess. The proposed two-step approach is valid for multilayered structures, and the local minima problem commonly encountered with optimization routines are also avoided. A number of carbon-fiber composite materials along and, transverse to the fiber orientation are measured using the proposed method. Finally, a brief uncertainty analysis, to study the effect of air-gaps on waveguide measurements, is carried out.
Advances in Ecology for Population and Community Specialists (1995)

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
FK 506 dosage in human organ transplantation. (1990)

FK 506 has proved to be a new potent immunosuppressive drug in the initial clinical trials, which began at the University Hospital in Pittsburgh in February 1989.1 FK 506 has been used as either primary immunosuppressant for liver, kidney, heart, lung, and heart/lung transplants, or as rescue therapy for liver or kidney transplants.

FK 506 is a macrolide derived from Streptomyces tsuku-baensis. FK 506 suppresses T-cell-mediated immunity by suppressing interleukin-2 synthesis in T cells.2

The optimal dose of FK 506 in animals to achieve immunosuppression varies from 1-2 mg/kg in rats to 12-18 mg in baboons, showing a difference among species.3

The aim of this study was to look at the amount of FK 506 used in human organ transplantation and the current maintenance doses of FK 506 and steroids in these patients.
Categorizing and mining concept drifting data streams (2008)

Mining concept drifting data streams is a defining challenge for data mining research. Recent years have seen a large body of work on detecting changes and building prediction models from stream data, with a vague understanding on the types of the concept drifting and the impact of different types of concept drifting on the mining algorithms. In this paper, we first categorize concept drifting into two scenarios: Loose Concept Drifting (LCD) and Rigorous Concept Drifting (RCD), and then propose solutions to handle each of them separately. For LCD data streams, because concepts in adjacent data chunks are sufficiently close to each other, we apply kernel mean matching (KMM) method to minimize the discrepancy of the data chunks in the kernel space. Such a minimization process will produce weighted instances to build classifier ensemble and handle concept drifting data streams. For RCD data streams, because genuine concepts in adjacent data chunks may randomly and rapidly change, we propose a new Optimal Weights Adjustment (OWA) method to determine the optimum weight values for classifiers trained from the most recent (up-to-date) data chunk, such that those classifiers can form an accurate classifier ensemble to predict instances in the yet-to-come data chunk. Experiments on synthetic and real-world datasets will show that weighted instance approach is preferable when the concept drifting is mainly caused by the changing of the class prior probability; whereas the weighted classifier approach is preferable when the concept drifting is mainly triggered by the changing of the conditional probability.
Chemopreventive effects of alpha-santalol on skin tumor development in CD-1 and SENCAR mice. (2003)

Studies from our laboratory have indicated skin cancer chemopreventive effectsof sandalwood oil in CD-1 mice. The purpose of this investigation was to study the skin cancer chemopreventive effects of alpha-santalol, a principal component of sandalwood oil in CD-1 and SENCAR mice. alpha-Santalol was isolated from sandalwood oil by distillation under vacuum and characterized by nuclear magnetic resonance and gas chromatography-mass spectrometry. Chemopreventive effects of alpha-santalol were determined during initiation and promotion phase in female CD-1 and SENCAR mice. Carcinogenesis was initiated with 7,12-dimethylbenz(a)anthracene and promoted with 12-O-tetradecanoylphorbol-13-acetate (TPA). The effects of alpha-santalol treatment on TPA-induced epidermal ornithine decarboxylase (ODC) activity and (3)H-thymidine incorporation in epidermal DNA of CD-1 and SENCAR mice were also investigated. alpha-Santalol treatment during promotion phase delayed the papilloma development by 2 weeks in both CD-1 and SENCAR strains of mice. alpha-Santalol treatment during promotion phase significantly (P < 0.05) decreased the papilloma incidence and multiplicity when compared with control and treatment during initiation phase during 20 weeks of promotion in both CD-1 and SENCAR strains of mice. alpha-Santalol treatment resulted in a significant (P < 0.05) inhibition in TPA-induced ODC activity and incorporation of (3)H-thymidine in DNA in the epidermis of both strains of mice. alpha-Santalol significantly prevents papilloma development during promotion phase of 7,12-dimethylbenz(a)anthracene-TPA carcinogenesis protocol in both CD-1 and SENCAR mice, possibly by inhibiting TPA-induced ODC activity and DNA synthesis. alpha-Santalol could be an effective chemopreventive agent for skin cancer. Additional experimental and clinical studies are needed to investigate the chemopreventive effect of alpha-santalol in skin cancer.
Production of Radioisotopes with HFETR (1985)

Production of radioisotopes with HFETR is a available way that raise theyield and improve quality of the products.In this paper the problems that caremust be taken in target irradiation and the fundamental technological processesfor production of high radioactivity 60 Co teletherapy source, 60 Co source for bra-chytherapy and 113m In generator are expounded.Some suggestions that reduce pro-duction cost are presented.
Prevention of shingles: safety and efficacy of live zoster vaccine. (2007)

Primary infection with varicella zoster virus (VZV) causes chickenpox (varicella) after which virus becomes latent in cranial nerve, dorsal root and autonomic ganglia along the entire neuraxis. Virus may later reactivate, causing shingles (zoster), characterized by pain and rash restricted to 1-3 dermatomes. More than 40% of zoster patients over age 60 develop postherpetic neuralgia (PHN), pain that persists for months to years. The socioeconomic impact of primary varicella infection has been lessened by introduction of VZV vaccine for children. However, the effect of childhood vaccination on the incidence of zoster is unknown. Virus reactivation correlates with waning cell-mediated immunity (CMI) to VZV with normal aging. Adults exposed to children with varicella may have a boost in CMI to VZV. For at least several more decades, the incidence of zoster may increase as the elderly population grows. The anticipated increase in zoster burden of illness in future decades was a major impetus for the Shingles Prevention Study, a prospective, double-blind, placebo-controlled trial of attenuated VZV vaccine to prevent zoster in older adults. This review discusses clinical and virological aspects of zoster and its complications, current treatment options, and VZV vaccine development along with its future role in disease prevention.
Porous Metals and Metal Foams Made from Powders (2012)

This short review describes the main powder metallurgy-based manufacturing routes, highlighting the key aspects of the relevant technology involved and the types of foam structures that result.
Enhanced detection of the pathogenic prion protein by its supramolecular association with para-sulfonato-calix[n]arene derivatives (2007)

The supramolecular interaction between the pathogenic form of the prion protein and derivatives of the para-sulfonato-calix[n]arenes has been demonstrated and two putative binding sites determined; this interaction leads to an amplification of the Western Blot immunological detection of the prion protein by the SAF84 antibody.
Melt Viscosities of Dimethylpolysiloxanes (1955)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMelt Viscosities of DimethylpolysiloxanesE. L. Warrick, W. A. Piccoli, and F. O. StarkCite this: J. Am. Chem. Soc. 1955, 77, 19, 5017–5018Publication Date (Print):October 1, 1955Publication History Published online1 May 2002Published inissue 1 October 1955https://pubs.acs.org/doi/10.1021/ja01624a024https://doi.org/10.1021/ja01624a024research-articleACS PublicationsRequest reuse permissionsArticle Views107Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Survey of Energy-Cognizant Scheduling Techniques (2012)

Execution time is no longer the only metric by which computational systems are judged. In fact, explicitly sacrificing raw performance in exchange for energy savings is becoming a common trend in environments ranging from large server farms attempting to minimize cooling costs to mobile devices trying to prolong battery life. Hardware designers, well aware of these trends, include capabilities like DVFS (to throttle core frequency) into almost all modern systems. However, hardware capabilities on their own are insufficient and must be paired with other logic to decide if, when, and by how much to apply energy-minimizing techniques while still meeting performance goals. One obvious choice is to place this logic into the OS scheduler. This choice is particularly attractive due to the relative simplicity, low cost, and low risk associated with modifying only the scheduler part of the OS. Herein we survey the vast field of research on energy-cognizant schedulers. We discuss scheduling techniques to perform energy-efficient computation. We further explore how the energy-cognizant scheduler's role has been extended beyond simple energy minimization to also include related issues like the avoidance of negative thermal effects as well as addressing asymmetric multicore architectures.
Limits to Microbial Growth in Soil (1982)

More organic carbon was released into solution from soils that had been air-dried and rewetted than from the natural soils. Irradiation and autoclaving of a range of air-dried or field soils greatly increased the amount of carbon that was released into solution. The carbon released appeared to provide substrates for fungal spore germination and bacterial growth, thereby relieving microbiostasis. The percentage germination of Penicillium citrinum spores was at least doubled in sterilized soil and halved in untreated soil compared with spores germinating in the absence of soil. In general, a streptomycin-resistant strain of Agrobacterium radiobacter made significant growth only in sterilized soils.
IVAN: Intelligent Van for the Distribution of Pharmaceutical Drugs (2012)

This paper describes a telematic system based on an intelligent van which is capable of tracing pharmaceutical drugs over delivery routes from a warehouse to pharmacies, without altering carriers’ daily conventional tasks. The intelligent van understands its environment, taking into account its location, the assets and the predefined delivery route; with the capability of reporting incidences to carriers in case of failure according to the established distribution plan. It is a non-intrusive solution which represents a successful experience of using smart environments and an optimized Radio Frequency Identification (RFID) embedded system in a viable way to resolve a real industrial need in the pharmaceutical industry. The combination of deterministic modeling of the indoor vehicle, the implementation of an ad-hoc radiating element and an agile software platform within an overall system architecture leads to a competitive, flexible and scalable solution.
Making the System Work for Home Care Quality (2009)

The post-acute and long-term care systems are changing rapidly, with an increasingly important role being played by home care. Under the current system, home care does not consistently meet the needs of older people living in the community. This problem is caused, in large part, by the existing system of financing and regulating home care. This paper examines how the current system funded by Medicare, Medicaid, state programs, private insurance, and out-of-pocket spending affects the delivery and quality of home care services. Specifically, this paper analyzes how financing, coverage of services, reimbursement, quality regulation and assurance, and information coordination affects the quality of home care. The paper concludes by drawing implications for policy.
Incorporation of phosphatidylserine improves efficiency of lipid based gene delivery systems (2022)

The essential homeostatic process of dead cell clearance (efferocytosis) is used by viruses in an act of apoptotic mimicry. Among others, virions leverage phosphatidylserine (PS) as an essential "eat me" signal in viral envelopes to increase their infectivity. In a virus-inspired biomimetic approach, we demonstrate that PS can be incorporated into non-viral lipid nanoparticle (LNP) pDNA/mRNA constructs to enhance cellular transfection. The inclusion of the bioactive PS leads to an increased ability of LNPs to deliver nucleic acids in vitro to cultured HuH-7 hepatocellular carcinoma cells resulting in a 6-fold enhanced expression of a transgene. Optimal PS concentrations are in the range of 2.5 to 5% of total lipids. PS-decorated mRNA-LNPs show a 5.2-fold enhancement of in vivo transfection efficiency as compared to mRNA-LNPs devoid of PS. Effects were less pronounced for PS-decorated pDNA-LNPs (3.2-fold increase). Incorporation of small, defined amounts of PS into gene delivery vectors opens new avenues for efficient gene therapy and can be easily extended to other therapeutic systems.
Observation of bulk defects by scanning tunneling microscopy and spectroscopy: Arsenic antisite defects in GaAs (1993)

The scanning tunneling microscope is used to study arsenic-related point defects in low-temperature-grown GaAs. Tunneling spectroscopy reveals a band of donor states located near ${\mathit{E}}_{\mathit{v}}$+0.5 eV arising from the defects. Images of this state reveal a central defect core, with two satellites located about 15 \AA{} from the core. The structure of the defect is found to be consistent with that of an isolated arsenic antisite defect (As on a Ga site) in a tetrahedral environment.
Copper Toxicity in Woody Ornamentals (1976)

Rhododendron obtusum Planch. 'Delaware Valley' (Delaware Valley Azalea), Buxus sempervirens L. (common boxwood) and Cotoneaster divaricata Rehd. and Wils. (spreading cotoneaster) grown in sand culture received a complete nutrient solution containing Cu concns ranging from 0.032 ppm to 100 ppm. Development of Cu toxicity symptoms were recorded for 8 weeks, then Cu, Fe, and Mn levels in roots, stems, and leaves were determined. Chronic Cu toxicity symptoms were interveinal chlorosis and stunted growth. Acute Cu toxicity caused wilting, desiccation, and death of all affected plants. Tissue Fe and Mn levels were not consistently correlated to the Cu concn of the treatment solution. Only tissue Cu levels proved useful as an index of Cu toxicity.
Tandem Catalysis by Palladium Nanoclusters Encapsulated in Metal–Organic Frameworks (2014)

A bifunctional Zr-MOF catalyst containing palladium nanoclusters (NCs) has been developed. The formation of Pd NCs was confirmed by transmission electron microscopy (TEM) and extended X-ray absorption fine structure (EXAFS). Combining the oxidation activity of Pd NCs and the acetalization activity of the Lewis acid sites in UiO-66-NH2, this catalyst (Pd@UiO-66-NH2) exhibits excellent catalytic activity and selectivity in a one-pot tandem oxidation-acetalization reaction. This catalyst shows 99.9% selectivity to benzaldehyde ethylene acetal in the tandem reaction of benzyl alcohol and ethylene glycol at 99.9% conversion of benzyl alcohol. We also examined various substituted benzyl alcohols and found that alcohols with electron-donating groups showed better conversion and selectivity compared to those with electron-withdrawing groups. We further proved that there was no leaching of active catalytic species during the reaction and the catalyst can be recycled at least five times without significant deactivation.
Follow-up on "The Case of Donnie J" (1991)

Commentary| April 01 1991 Follow-up on "The Case of Donnie J" R. J. H. R. J. H. Search for other works by this author on: This Site PubMed Google Scholar Pediatr Rev (1991) 12 (10): 291. https://doi.org/10.1542/pir.12-10-291 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation R. J. H.; Follow-up on "The Case of Donnie J". Pediatr Rev April 1991; 12 (10): 291. https://doi.org/10.1542/pir.12-10-291 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search toolbar search search input Search input auto suggest filter your search All PublicationsAll JournalsPediatrics In ReviewPediatricsHospital PediatricsNeoReviewsAAP Grand RoundsAAP NewsAll AAP Sites Search Advanced Search Few review articles published in Pediatrics in Review have elicited such strong disagreements with the recommendations of the author as "The Case of Donnie J," published in our July 1990 issue. The disagreements were in three areas: (1) the extensiveness of the workup and large number of immunizations recommended by Dr Burg at the first visit; (2) the pejorative nature of descriptions of the mother, such as that she was a "dead head"; and (3) the practicality of treating such a patient in private practice. Dr Burg was asked to comment on these letters.APPROPRIATENESS OF A COMPLETE WORKUP OF DONNIE J AT THE FIRST VISIT Topics: appropriateness, immunization, private practice, vaccines This content is only available via PDF. Copyright © 1991 by the American Academy of Pediatrics1991 You do not currently have access to this content.
Extraction of a Highly Potent Penicillin Inactivator from Penicillin Resistant Staphylococci (1944)

A highly potent penicillin inactivator has been extracted from 7 strains of Staph. aureus (coagulase positive), all of which were naturally penicillin resistant. No such inhibitor was present in extracts of 7 penicillin sensitive strains of Staph. aureus.
Admission control and bandwidth management for VLANs (2002)

We explore how 802.1Q(p) can be successfully exploited within the DIFFSERV framework. Borrowing from work on INTSERV and SBM, but in keeping with a KISS philosophy, we analyze how, in combination with admission control and bandwidth management, we can deliver services with guarantees of quality for applications such as VoIP on a per-VLAN basis. In conclusion, we show that it possible to use a pure layer-2 infrastructure to support large-scale deployment of new services in a wide regional area.