gebhart/patrepeval huggingface dataset:
SceneCode: Monocular Dense Semantic Reconstruction using Learned Encoded Scene Representations (2019)

Systems which incrementally create 3D semantic maps from image sequences must store and update representations of both geometry and semantic entities. However, while there has been much work on the correct formulation for geometrical estimation, state-of-the-art systems usually rely on simple semantic representations which store and update independent label estimates for each surface element (depth pixels, surfels, or voxels). Spatial correlation is discarded, and fused label maps are incoherent and noisy. We introduce a new compact and optimisable semantic representation by training a variational auto-encoder that is conditioned on a colour image. Using this learned latent space, we can tackle semantic label fusion by jointly optimising the low-dimenional codes associated with each of a set of overlapping images, producing consistent fused label maps which preserve spatial correlation. We also show how this approach can be used within a monocular keyframe based semantic mapping system where a similar code approach is used for geometry. The probabilistic formulation allows a flexible formulation where we can jointly estimate motion, geometry and semantics in a unified optimisation.
Electrical and Computer Engineering Response to Reviewers' Report (2013)

Electrical and Computer Engineering Response to Reviewers' Report for Academic Program Review
ID based generalized signcryption. (2008)

Abstract: Generalized signcryption is a new cryptographic primitive in which a signcryption scheme can work as an encryption scheme as well as a signature scheme. This paper presents an identity based generalized signcryption scheme based on bilinear pairing and discusses its security for message confidentiality non repudiation and ciphertext authentication.
A meta‐analysis of clinical trials of paclitaxel‐ and sirolimus‐eluting stents in patients with obstructive coronary artery disease (2004)

Paclitaxel- and sirolimus-eluting stents significantly reduced the incidence of major adverse cardiac events, restenosis rates, and late loss of arterial lumen diameter as compared with bare metal stents.
A Scalable Procedure for Light-Induced Benzylic Brominations in Continuous Flow (2013)

A continuous-flow protocol for the bromination of benzylic compounds with N-bromosuccinimide (NBS) is presented. The radical reactions were activated with a readily available household compact fluorescent lamp (CFL) using a simple flow reactor design based on transparent fluorinated ethylene polymer (FEP) tubing. All of the reactions were carried out using acetonitrile as the solvent, thus avoiding hazardous chlorinated solvents such as CCl4. For each substrate, only 1.05 equiv of NBS was necessary to fully transform the benzylic starting material into the corresponding bromide. The general character of the procedure was demonstrated by brominating a diverse set of 19 substrates containing different functional groups. Good to excellent isolated yields were obtained in all cases. The novel flow protocol can be readily scaled to multigram quantities by operating the reactor for longer time periods (throughput 30 mmol h(-1)), which is not easily possible in batch photochemical reactors. The bromination protocol can also be performed with equal efficiency in a larger flow reactor utilizing a more powerful lamp. For the bromination of phenylacetone as a model, a productivity of 180 mmol h(-1) for the desired bromide was achieved.
Presentación N°154 (2019)

Realidad: Revista de Ciencias Sociales y Humanidades No. 154, 2019: 1-3
Randomized initialization protocols for ad hoc networks (2000)

Ad hoc networks are self-organizing entities that are deployed on demand in support of various events including collaborative computing, multimedia classroom, disaster-relief, search-and-rescue, interactive mission planning, and law enforcement operations. One of the fundamental tasks that have to be addressed when setting up an ad hoc network (AHN, for short) is initialization. This involves assigning each of the n stations in the AHN a distinct ID number (e.g., a local IP address) in the range from 1 to n. Our main contribution is to propose efficient randomized initialization protocols for AHNs. We begin by showing that if the number n of stations is known beforehand, an n-station, single-channel AHN can be initialized with probability exceeding 1-(1/n), in en+O(/spl radic/(nlogn)) time slots, regardless of whether the AHN has collision detection capability. We then go on to show that even if n is not known in advance, an n-station, single-channel AHN with collision detection can be initialized with probability exceeding 1-(1/n), in (10n)/3+O(/spl radic/(n 1n n)) time slots. Using this protocol as a stepping stone, we then present an initialization protocol for the n-station, k-channel AHN with collision detection that terminates with probability exceeding 1-(1/n), in (10n)/(3k)+O(/spl radic/(n 1n n)/k) time slots. Finally, we look at the case where the collision detection capability is not present. Our first result in this direction is to show that the task of electing a leader in an n-station, single-channel AHN can be completed with probability exceeding 1-(1/n), in fewer than 11.37(iog n)/sup 2/+2.39 log n time slots. This leader election protocol allows us to design an initialization protocol for the n-station, single-channel AHN with no collision detection that terminates with probability exceeding 1-(1/n), in fewer than 5.67n+O(/spl radic/(n 1n n)) time slots, even if n is not known beforehand. We then discuss an initialization protocol for the n-station, k-channel AHN with no collision detection that terminates with probability exceeding 1-(1/n), in fewer than 5.67(n/k)+O(/spl radic/(n 1n n)/k) time slots, whenever k/spl les/n/((log n)/sup 3/).
Inverse opal ceria–zirconia: architectural engineering for heterogeneous catalysis (2008)

The application of inverse opal structured materials is extended to the ceria–zirconia (Ce0.5Zr0.5O2) system and the significance of material architecture on heterogeneous catalysis, specifically, chemical oxidation, is examined.
Negative schizophrenic symptomatology and the PCP (phencyclidine) model of schizophrenia. (1987)

Amphetamine induced psychosis has for the past 30 years provided a useful model for the study of schizophrenia. The amphetamine model, however, has been shown to have a number of shortcomings including an inability to model the deficit symptoms of schizophrenia. PCP (phencyclidine) has been shown to be capable of inducing a schizophreniform psychosis consisting of both productive and defict symptomatology. PCP induced psychosis, therefore, may provide a useful model of schizophrenia. This paper reviews the literature concerning the PCP model of schizophrenia and provides some independent confirmation of the ability of PCP to modulate mesocortical dopaminergic activity. Since PCP appears to mediate its CNS effects via a subclass of glutamate receptors, a possible glutamate theory of schizophrenia is proposed.
Large-Scale Phosphoproteomics Reveals Shp-2 Phosphatase-Dependent Regulators of Pdgf Receptor Signaling (2018)

Despite its low cellular abundance, phosphotyrosine (pTyr) regulates numerous cell signaling pathways in health and disease. We applied comprehensive phosphoproteomics to unravel differential regulators of receptor tyrosine kinase (RTK)-initiated signaling networks upon activation by Pdgf-ββ, Fgf-2, or Igf-1 and identified more than 40,000 phosphorylation sites, including many phosphotyrosine sites without additional enrichment. The analysis revealed RTK-specific regulation of hundreds of pTyr sites on key signaling molecules. We found the tyrosine phosphatase Shp-2 to be the master regulator of Pdgfr pTyr signaling. Application of a recently introduced allosteric Shp-2 inhibitor revealed global regulation of the Pdgf-dependent tyrosine phosphoproteome, which significantly impaired cell migration. In addition, we present a list of hundreds of Shp-2-dependent targets and putative substrates, including Rasa1 and Cortactin with increased pTyr and Gab1 and Erk1/2 with decreased pTyr. Our study demonstrates that large-scale quantitative phosphoproteomics can precisely dissect tightly regulated kinase-phosphatase signaling networks.
Polarization scrambling using photoelastic modulator: Application to linear dichroism measurement (1977)

The signal-to-noise ratio in linear dichrosim measurements using the polarization modulation technique is hindered by the presence of fictitious signals originating from briefringence and polarization sensitivity in the optical components. We have shown both theoretically and experimentally that such artifacts resulting from optical elements after the sample can be removed by placing a second modulator immediately after the sample. The second modulator, which must be of a different frequency than the first, and which must be adjusted to a specific that the synchronous time average of the fictitious signal is zero. The true linear dichroism signal is unaffected. In wavelength regions where thjere are no fictitious signals. The scrambler neither introudces artifact signals nor does it affect the real signals. Fictitious signals due to imperfections in optical components before or within the sample itself cannot be nulled in the same manner.
The Nogo/Nogo Receptor (NgR) Signal Is Involved in Neuroinflammation through the Regulation of Microglial Inflammatory Activation (2015)

Microglia have been proposed to play a pivotal role in the inflammation response of the CNS by expressing a range of proinflammatory enzymes and cytokines under pathological stimulus. Our previous study has confirmed that Nogo receptor (NgR), an axon outgrowth inhibition receptor, is also expressed on microglia and regulates cell adhesion and migration behavior in vitro. In the present study, we further investigated the proinflammatory effects and possible mechanisms of Nogo on microglia in vitro. In this study, Nogo peptide, Nogo-P4, a 25-amino acid core inhibitory peptide sequence of Nogo-66, was used. We found that Nogo-P4 was able to induce the expression of inducible nitric-oxide synthase and cyclooxygenase-2 and the release of proinflammatory cytokines, including IL-1β, TNF-α, NO, and prostaglandin E2 in microglia, which could be reversed by NEP1-40 (Nogo-66(1-40) antagonist peptide), phosphatidylinositol-specificphospholipase C, or NgR siRNA treatment. After Nogo-P4 stimulated microglia, the phosphorylation levels of NF-κB and STAT3 were increased obviously, which further mediated microglia expressing proinflammatory factors induced by Nogo-P4. Taken together, we concluded that Nogo peptide could directly take part in CNS inflammatory process by influencing the expression of proinflammatory factors in microglia, which were related to the NF-κB and STAT3 signal pathways. Besides neurite outgrowth restriction, the Nogo/NgR signal might be involved in multiple processes in various inflammation-associated CNS diseases.
Uptake and respiration of organic compounds and heterotrophic growth in <i>Pediastrum duplex</i> (Meyen)* (1977)

SUMMARY. Axenic cultures of Pediastrum duplex , a green alga prominent in Lake Kinneret, Israel, assimilated and respired amino acids, acetate, glucose, glycollate and glycerol under conditions of light or darkness. Increased rates of uptake and respiration were observed in nutrient (P and N) depleted medium. Although ineffective in moderate light (30–100 μ Einstein m −2 s −1 ) glycerol, glucose and leucine, but not glycollate, stimulated growth and yields under faint light (∼ 2 μ Einstein m −2 s −1 ). In the dark, glycerol (and sometimes leucine) permitted growth. Kinetic studies with leucine indicated an active uptake mechanism effective at substrate concentrations from 0.5 to 47 μg 1 −1 .
Altered neural connectivity in excitatory and inhibitory cortical circuits in autism (2013)

Converging evidence from diverse studies suggests that atypical brain connectivity in autism affects in distinct ways short- and long-range cortical pathways, disrupting neural communication and the balance of excitation and inhibition. This hypothesis is based mostly on functional non-invasive studies that show atypical synchronization and connectivity patterns between cortical areas in children and adults with autism. Indirect methods to study the course and integrity of major brain pathways at low resolution show changes in fractional anisotropy (FA) or diffusivity of the white matter in autism. Findings in post-mortem brains of adults with autism provide evidence of changes in the fine structure of axons below prefrontal cortices, which communicate over short- or long-range pathways with other cortices and subcortical structures. Here we focus on evidence of cellular and axon features that likely underlie the changes in short- and long-range communication in autism. We review recent findings of changes in the shape, thickness, and volume of brain areas, cytoarchitecture, neuronal morphology, cellular elements, and structural and neurochemical features of individual axons in the white matter, where pathology is evident even in gross images. We relate cellular and molecular features to imaging and genetic studies that highlight a variety of polymorphisms and epigenetic factors that primarily affect neurite growth and synapse formation and function in autism. We report preliminary findings of changes in autism in the ratio of distinct types of inhibitory neurons in prefrontal cortex, known to shape network dynamics and the balance of excitation and inhibition. Finally we present a model that synthesizes diverse findings by relating them to developmental events, with a goal to identify common processes that perturb development in autism and affect neural communication, reflected in altered patterns of attention, social interactions, and language.
ZDOCK predictions for the CAPRI challenge (2003)

The CAPRI Challenge is a blind test of protein-protein-docking algorithms that predict the complex structure from the crystal structures of the interacting proteins. We participated in both rounds of this blind test and submitted predictions for all seven targets, relying mainly on our Fast Fourier Transform based algorithm ZDOCK that combines shape complementarity, desolvation, and electrostatics. Our group made good predictions for three targets and had at least some success with three others. Implications of the treatment of prior biological information as well as contributions of manual inspection to docking predictions are also discussed.
Three-dimensional In Vivo Mapping of Brain Lesions in Humans (1992)

We describe a multistep technique for three-dimensional reconstruction and analysis of brain lesions in vivo, based on the manipulation of magnetic resonance raw data obtained with a special protocol. The technique permits the direct visual identification of neuroanatomical landmarks in each brain specimen and eliminates the need to rely on averaged templates of human brain sections, which can be a source of lesion localization error. The technique also allows for the bidirectional cross-reference between data points in two-dimensional slices and in volume reconstruction and for the projection of subcortical structures onto the three-dimensional cortical surface. The three-dimensional lesion mapping technique can be applied to research with the lesion method in both human and nonhuman primates, to the planning of neurosurgical lesion approach, and to the teaching of neuroanatomy.
Molecular identification and characterization of the platelet ADP receptor targeted by thienopyridine antithrombotic drugs (2001)

ADP plays a critical role in modulating thrombosis and hemostasis. ADP initiates platelet aggregation by simultaneous activation of two G protein-coupled receptors, P2Y1 and P2Y12. Activation of P2Y1 activates phospholipase C and triggers shape change, while P2Y12 couples to Gi to reduce adenylyl cyclase activity. P2Y12 has been shown to be the target of the thienopyridine drugs, ticlopidine and clopidogrel. Recently, we cloned a human orphan receptor, SP1999, highly expressed in brain and platelets, which responded to ADP and had a pharmacological profile similar to that of P2Y12. To determine whether SP1999 is P2Y12, we generated SP1999-null mice. These mice appear normal, but they exhibit highly prolonged bleeding times, and their platelets aggregate poorly in responses to ADP and display a reduced sensitivity to thrombin and collagen. These platelets retain normal shape change and calcium flux in response to ADP but fail to inhibit adenylyl cyclase. In addition, oral clopidogrel does not inhibit aggregation responses to ADP in these mice. These results demonstrate that SP1999 is indeed the elusive receptor, P2Y12. Identification of the target receptor of the thienopyridine drugs affords us a better understanding of platelet function and provides tools that may lead to the discovery of more effective antithrombotic therapies.
Offshore Code Comparison Collaboration within IEA Wind Task 23: Phase IV Results Regarding Floating Wind Turbine Modeling (2010)

A novel concept for offshore floating wind turbines (Deep Wind) was presented by the authors in [1].This paper deals with new developments of the novel concept.Three configurations, each with different degrees of freedom, have been selected to be presented in this paper.The first configuration, characterized by the lowest number of degrees of freedom, is investigated by an aero-elastic code.
Transfer Function Analysis of Non-Uniformly Distributed Parameter Systems (1993)

Abstract This paper studies a transfer function formulation for general one-dimensional, non-uniformly distributed systems subject to arbitrary boundary conditions and external disturbances. The purpose is to provide an useful alternative for modeling and analysis of distributed parameter systems. In the development, the system equations of the non-uniform system are cast into a state space form in the Laplace transform domain. The system response and distributed transfer functions are derived in term of the fundamental matrix of the state space equation. Two approximate methods for evaluating the fundamental matrix are proposed. With the transfer function formulation, various dynamics and control problems for the non-uniformly distributed system can be conveniently addressed. The transfer function analysis is also applied to constrained/combined non-uniformly distributed systems.
Tyr-503 of β-galactosidase (<i>Escherichia coli</i>) plays an important role in degalactosylation (1999)

Substitutions for Tyr-503 of beta-galactosidase caused large decreases of the activity. Both the galactosylation (k2) and degalactosylation (k3) rates were decreased. Substitutions by residues without transferable protons, caused k3 to decrease much more than k2 while substitutions with residues having transferable protons, caused approximately equal decreases of k2 and k3. Several lines of evidence showed this. The Km values of the substituted enzymes were much smaller than those for the wild type if the substituted amino acid residues did not have transferable protons; this was not the case when the substituted residues had transferable protons. Inhibition studies showed that the Km values were not small because of small Ks values but were small because of relatively small k3 values (compared with the k2 values). The conclusion that the k3 values are small relative to k2 upon substitution with residues without transferable protons is also based upon other studies: studies indicating that the reaction rates were similar with different substrates, studies in the presence of alcohol acceptors, studies showing that the rate of inactivation by 2,4-dinitrophenyl-2-deoxy-2-F-beta-D-galactopyranoside decreased much less than the rate of reactivation; studies on burst kinetics, and pH studies. The data suggest that Tyr-503 may be important for the degalactosylation reaction because of its ability to transfer protons and thereby facilitate cleavage of the transient covalent bond between galactose and Glu-537.
Multiuser Collaboration with Networked Mobile Devices (2006)

This paper describes a multiuser collaboration infrastructure that enables multiple mission scientists to remotely and collaboratively interact with the visualization and planning software, using wireless networked personal digital assistants and other mobile devices. The infrastructure includes (1) human-computer interaction components to provide natural, fast, and accurate inputs, (2) a communications protocol to ensure reliable and efficient coordination of the input devices and host computers, (3) an application-independent middleware that maintains the states, sessions, and interactions of individual users of the software applications, and (4) an application programming interface to enable tight integration of applications and the middleware. The resulting technologies not only are applicable to NASA mission operations, but also useful in other situations such as design reviews, brainstorming sessions, and business meetings, as they can benefit from having the participants concurrently interact with the software applications (e.g., presentation applications and CAD design tools) to illustrate their ideas and provide inputs
Investigation into Carbon-Trigger Vacuum Switches for High-Voltage, High-Current Switch Applications (2006)

We present results of research into the operation of triggered vacuum switches. These switches find use in applications requiring high standoff voltages as well as high discharge currents
Zirconocenes as Photoinitiators for Free-Radical Polymerisation of Acrylates (2002)

This paper reports the photochemical behaviour of unbridged (1−6) and bridged zirconocenes (7r, 7m), whose substituents differ in both electron-donor and steric properties. The study of the electronic spectra and EPR spin-trapping experiments showed the photogeneration of ligand- and zirconium-centred radicals at wavelengths higher than 350 nm. This feature makes these complexes suitable as photoinitiators for radical polymerisation processes. tert-Butyl acrylate polymerisation has been studied in detail and the results are particularly encouraging as far as the reaction yields and the stereochemistry are concerned. In particular, the complexes 4−6, due to the tuneability of their structure and their stability in solution, look the most promising reagents.
An Open Trial of Light Therapy for Women With Seasonal Affective Disorder and Comorbid Bulimia Nervosa (2001)

These results suggest that therapeutic effects of light therapy on mood and bulimic symptoms in patients with SAD and comorbid bulimia nervosa are sustained over at least 4 weeks. However, the low abstinence rate in bulimic symptoms indicates that light therapy may be most effectively used as an adjunctive treatment to medications and/or psychotherapy for bulimia nervosa.
Some Problems of Antimicrobial Chemotherapy in the Medical Insurance (1985)

近年は抗生物質をはじめとする抗菌剤の研究・開発は目覚ましいものがあり, 本邦でも世界各国が注目する新規の薬剤が開発されている. 本邦における細菌感染症に対する化学療法の普及率は世界第1位に属しているが, しかし, 化学療法の現況をみると, 化学療法が極めて安易に, また無計画に行われているきらいが多く, 反省すべき点のあることも事実であり, 抗菌剤の適切な選択と使用, 乱用には注意が必要である. 化学療法を医療保険の面からみると, 査定率は本学ではγ-グロブリン製剤に次いで多く, その理由として, 適応症, 有効菌種の問題, 用量, 用法の問題, 併用の問題, 術後感染予防における抗菌剤の投与の問題などが考えられてはいるが, 実際の臨床の立場との間にはいくつかの問題点があることも事実である. 今回は汎用されている抗菌剤を中心に医療保険の立場からみた問題点を指摘してみたい.
Infra-red absorption of gallium phosphide containing boron (1969)

Absorption due to boron vibrational modes in GaP has been measured. At 20 °K gap modes of 11B and 10B occur at 284·2 and 293·8 cm-1, local modes occur at 571·0 and 593·6 cm-1 and local +gap modes occur at 849·0 and 882·4 cm-1. An approximate calculation of the boron vibrational mode frequencies gives reasonable agreement with experiment.