gebhart/patrepeval huggingface dataset:
Molecular Reactions of Protein PhosphatasesInsights from Structure and Chemistry (2001)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMolecular Reactions of Protein PhosphatasesInsights from Structure and ChemistryMichael D. Jackson and John M. DenuView Author Information Department of Biochemistry and Molecular Biology, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97201 Cite this: Chem. Rev. 2001, 101, 8, 2313–2340Publication Date (Web):June 30, 2001Publication History Received16 October 2000Published online30 June 2001Published inissue 1 August 2001https://doi.org/10.1021/cr000247eCopyright © 2001 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views1272Altmetric-Citations182LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (1 MB) Get e-AlertsSUBJECTS:Crystal structure,Monomers,Peptides and proteins,Phosphates,Post-translational modification Get e-Alerts
Development of a Nucleoside Analog UV Light Sensor (2003)

Conjugation of the photosensitive nucleoside (E)-5-(2-methoxycarbonylethenyl)cytidine to biotin provided a means to attach this analogue to microparticles for dosimetry applications that require UV sensor mobility.
Chitosan‐Alginate Complex Coacervate Capsules: Effects of Calcium Chloride, Plasticizers, and Polyelectrolytes on Mechanical Stability (1988)

Abstract A method has been developed to form capsules with liquid cores where permeability can be modified without sacrificing membrane strength. The capsule is formed by dropwise addition of a 3% chitosan (polycation) solution into a 0.75% alignate (polyanion) solution. The resultant capsule consists of a liquid chitosan core with a hard alginate coating. The addition of CaCl 2 to chitosan and glucose to alginate increased capsule strength. The membranes formed were strong enough to require up to 100 Newton during uniaxial compression to burst a 6.4 mm diameter capsule.
Theoretical and experimental study of super-highelectromechanical coupling surface acoustic wave propagation in KNbO <sub>3</sub> single crystal (1997)

The propagation characteristics of surface acoustic waves (SAWs) and piezoelectric leaky surface waves in single crystal KNbO3 were investigated theoretically and experimentally. The results show that the electromechanical coupling coefficient of the surface wave propagating along the X-axis of the rotated Y-cut plane is very large, K2 = 0.53, compared to K2 of 0.055 for LiNbO3.
96. ThromboTrace??, a new diagnostic agent with high specificity to bind fibrin in vivo. (1998)

Nair, H.1; Shats, E.1; Burch, W.1; Browitt, R.1; Senden, T.2; Maxwell, L.3 Author Information
Thermosensitivity Patterns of Old vs. New World Cutaneous Strains of Leishmania Growing within Mouse Peritoneal Macrophages in Vitro (1983)

Infection of mouse peritoneal macrophages in vitro was used to examine the effect of elevated temperature on the intracellular replication of various strains of Leishmania. Of eight cutaneous strains examined, all grew optimally at 35 degrees C. At 37 degrees C the reduction in growth was most pronounced for the New World cutaneous strains, and at 39 degrees C three of four New World cutaneous strains were completely destroyed whereas all of the L. tropica strains survived and exhibited at least 100% growth after 3 days. The results of these in vitro studies correlate closely with the outcome of heat therapy on two patients with cutaneous disease, suggesting that, in general, cutaneous lesions due to L. tropica strains might be less responsive to heat therapy than lesions due to L. mexicana and related strains.
Posterosuperior Rotator Cuff Tears (2014)

The posterosuperior rotator cuff, composed of the supraspinatus and infraspinatus tendons, is the most common site for full-thickness rotator cuff tears and represents a significant source of shoulder disability worldwide. Recognition of and classification of full-thickness tear patterns are essential in order to optimize surgical treatment and to improve prognosis. Until recently, tear patterns have been described using one- or two-dimensional classification systems. Three-dimensional pattern recognition is critical to achieving the most successful outcome possible. For more complex patterns, a combination of side-to-side stitching, margin convergence, and interval slide techniques may be needed to achieve a tension-free tendon-bone repair. Biomechanical and anatomic evidence supports the use of linked double-row repairs for most full-thickness tears. Although double-row repairs seem to result in improved structural outcomes, clinical evidence has not shown differences in outcomes scores between single-row and double-row repairs. Single-row repair may be performed in partial-thickness, small full-thickness, or very massive, immobile tears, whereas double-row repair may be performed in most other cases.
Flexible Sensing Electronics for Wearable/Attachable Health Monitoring (2017)

Wearable or attachable health monitoring smart systems are considered to be the next generation of personal portable devices for remote medicine practices. Smart flexible sensing electronics are components crucial in endowing health monitoring systems with the capability of real-time tracking of physiological signals. These signals are closely associated with body conditions, such as heart rate, wrist pulse, body temperature, blood/intraocular pressure and blood/sweat bio-information. Monitoring such physiological signals provides a convenient and non-invasive way for disease diagnoses and health assessments. This Review summarizes the recent progress of flexible sensing electronics for their use in wearable/attachable health monitoring systems. Meanwhile, we present an overview of different materials and configurations for flexible sensors, including piezo-resistive, piezo-electrical, capacitive, and field effect transistor based devices, and analyze the working principles in monitoring physiological signals. In addition, the future perspectives of wearable healthcare systems and the technical demands on their commercialization are briefly discussed.
Uniformalization of the Pt-induced-trap concentration profile in silicon by the two-step diffusion method (1996)

A two-step diffusion method for uniformalizing the depth profile of the Pt-induced-trap concentration in silicon is proposed. Platinum is first diffused at a high temperature in nitrogen ambient, and then rediffused at a temperature lower than that of the first step. Experimental results show that this method makes the trap concentration near the surface of a wafer decrease and that deep inside the wafer increase. Therefore, the depth profiles of the trap concentration can be uniformalized throughout the entire wafer.
Query dependent ranking using K-nearest neighbor (2008)

Many ranking models have been proposed in information retrieval, and recently machine learning techniques have also been applied to ranking model construction. Most of the existing methods do not take into consideration the fact that significant differences exist between queries, and only resort to a single function in ranking of documents. In this paper, we argue that it is necessary to employ different ranking models for different queries and onduct what we call query-dependent ranking. As the first such attempt, we propose a K-Nearest Neighbor (KNN) method for query-dependent ranking. We first consider an online method which creates a ranking model for a given query by using the labeled neighbors of the query in the query feature space and then rank the documents with respect to the query using the created model. Next, we give two offline approximations of the method, which create the ranking models in advance to enhance the efficiency of ranking. And we prove a theory which indicates that the approximations are accurate in terms of difference in loss of prediction, if the learning algorithm used is stable with respect to minor changes in training examples. Our experimental results show that the proposed online and offline methods both outperform the baseline method of using a single ranking function.
Melting of small gold particles: Mechanism and size effects (1991)

We present extensive molecular-dynamics simulations of small gold particles of N=100--900 atoms. We use a many-body interatomic potential of proven accuracy for gold surfaces. Structural properties are determined with various annealing strategies. Our results provide for the first time a microscopic description of the melting transition of metal clusters, revealing in particular the formation of a liquid skin as precursor effect for N>350. The experimentally observed sharp decrease of the melting temperature with decreasing size is recovered. Implications for larger sizes, as well as for other metals, are discussed.
Spectroscopic investigation of CaAl<sub>12</sub>O<sub>19</sub>:M<sup>3+</sup>upon UV/vacuum–UV excitation: a comparison with SrAl<sub>12</sub>O<sub>19</sub>:M<sup>3+</sup>(M = Pr,Cr) (2007)

In order to evaluate the possibility of using Cr³⁺ co-doping to modify the emission properties of Pr³⁺-based quantum cutting phosphors, which emit one ultraviolet (UV) and one visible photon from each vacuum-UV photon absorbed, into phosphors that emit two visible photons, the optical spectroscopies between 150 and 750 nm of CaAl₁₂O₁₉:M³⁺ (M = Pr,Cr) were investigated and compared with those of SrAl₁₂O₁₉:M³⁺ using synchrotron radiation as one of the excitation sources. When Pr³⁺ is excited to its 4f5d states, cascade emission of UV photons from the ¹S₀ state followed by visible photons from the ³P₀ state are both observed in (Ca,Sr)Al₁₂O₁₉:Pr³⁺. Similar to SrAl₁₂O₁₉:M³⁺, there exist desirable spectral overlaps between Pr³⁺ ¹S₀ emissions and the Cr³⁺ higher multiplet absorptions in CaAl₁₂O₁₉, which should be favourable to the energy transfer from Pr³⁺ ¹S₀ to Cr³⁺, converting the UV photon from Pr³⁺ ¹S₀ into the red Cr³⁺ emission. However, the host absorption band and the Cr³⁺-related charge transfer band have an unfavourable overlap with the Pr³⁺ 4f5d states in the vacuum-UV region, preventing efficient selective Pr³⁺ excitation under radiation of Xe discharge, a prerequisite for the quantum cutting process.
Genomic Profiling of Prostate Cancers from African American Men (2009)

African American (AA) men have a higher incidence and significantly higher mortality rates from prostate cancer than white men, but the biological basis for these differences are poorly understood. Few studies have been carried out to determine whether there are areas of allelic loss or gain in prostate cancers from AA men that are overrepresented in or specific to this group. To better understand the molecular mechanisms of prostate cancer in AA men, we have analyzed 20 prostate cancers from AA men with high-density single-nucleotide polymorphism arrays to detect genomic copy number alterations. We identified 17 regions showing significant loss and 4 regions with significant gains. Most of these regions had been linked to prostate cancer by previous studies of copy number alterations of predominantly white patients.We identified a novel region of loss at 4p16.3, which has been shown to be lost in breast, colon, and bladder cancers. Comparison of our primary tumors with tumors from white patients from a previously published cohort with similar pathological characteristics showed higher frequency of loss of at numerous loci including 6q13-22, 8p21, 13q13-14, and 16q11-24 and gains of 7p21 and 8q24, all of which had higher frequencies in metastatic lesions in this previously published cohort. Thus, the clinically localized cancers from AA men more closely resembled metastatic cancers from white men. This difference may in part explain the more aggressive clinical behavior of prostate cancer in AA men.
The diagnosis of pituitary disease from human skeletal remains (1992)

Abstract The purpose of this study was to determine whether the radiological criteria once widely used when investigating pituitary disease in the living can be applied to early man. The material examined forms part of the assemblage of skulls in the Duckworth Collection in Cambridge. It proved possible to measure the sella turcica from the radiographs of 88 of 155 predynastic adult Egyptian skulls with an intact base. These were compared with the measurements from 41 of 76 adult Burmese skulls of more recent origin and those of a randomly selected sample of living Caucasian adults. There was a wide range of sellar volumes in all three groups. The results were subjected to statistical analysis. Opportunities to apply the results of this study have been limited to the assessment of sellar erosion in a predynastic Badarian, review of the diagnosis of acromegaly in a, presumed, early Egyptian and the investigation of a hydrocephalic skull. The radiological examination of human skeletal remains thought to show evidence of pituitary disease or hydrocephalus can make palaeopathological diagnoses more secure.
Exploring Thread and Memory Placement on NUMA Architectures: Solaris and Linux, UltraSPARC/FirePlane and Opteron/HyperTransport (2008)

Abstract. Modern shared memory multiprocessor systems commonly have non-uniform memory access (NUMA) with asymmetric memory bandwidth and latency characteristics. Operating systems now provide application programmer interfaces allowing the user to perform specific thread and memory placement. To date, however, there have been relatively few detailed assessments of the importance of memory/thread placement for complex applications. This paper outlines a framework for performing memory and thread placement experiments on Solaris and Linux. Thread binding and location specific memory allocation and its verification is discussed and contrasted. Using the framework, the performance characteristics of serial versions of lmbench, Stream and various BLAS libraries (ATLAS, GOTO, ACML on Opteron/Linux and Sunperf on Opteron, UltraSPARC/Solaris) are measured on two different hardware platforms (UltraSPARC/FirePlane and Opteron/HyperTransport). A simple model describing performance as a function of memory distribution is proposed and assessed for both the Opteron and UltraSPARC. 1
Dynamic thinning strategy for adaptive nulling in planar antenna arrays (2010)

An approach for the suppression of undesired signals impinging on a planar array is presented in this paper. The procedure is based on a dynamic thinning enforced to the array to move sidelobe nulls. Towards this aim, each element of the array is equipped with a radio-frequency switch which is used to connect/disconnect the element to the feeding network. While changing the thinning sequences, the number of active elements is kept as constant as possible to maintain unaltered the antenna gain. A set of representative results is reported to show the effectiveness of the approach.
Release of estrogen-induced glycoprotein with a molecular weight of 52,000 by breast cancer cells in primary culture. (1983)

In an attempt to find estrogen-specific responses in breast cancer, we have established primary cell culture from metastatic pleural effusions of breast cancer and have analyzed the proteins labeled by [35S]methionine and released into the culture medium using sodium dodecyl sulfate-polyacrylamide gel electrophoresis. We show that the synthesis of a Mr 52,000 glycoprotein which is released by metastatic breast cancer cells in primary cultures is stimulated by estradiol in four of six patients. This protein is similar to the Mr 52,000 protein of MCF7 cells on the basis of its mobility in one- and two-dimensional gel electrophoresis [the molecular weight of this protein was originally found to be 46,000; it is closer to 52,000 using labeled proteins from New England Nuclear as molecular weight markers], its immunoprecipitation by antisera raised against the Mr 52,000 protein, and its binding to concanavalin A. We conclude that, similar to some breast cancer cell lines, some metastatic breast cancers synthesize a Mr 52,000 glycoprotein which is regulated by estrogens and exported from the cells into the medium. This study also shows that some primary cultures established from metastatic breast cancer remain responsive to estradiol in vitro for the synthesis of specific proteins. More clinical studies are needed to prove the interest of the Mr 52,000 secreted protein as an additional marker of the hormone responsiveness of breast cancer.
The requirements for engineering degree courses and graduate engineers: an industrial viewpoint (1998)

There is currently great concern and controversy over the changing nature and perceived falling quality of engineering education in Britain, and over the critical shortage of school leavers with the necessary qualifications for entry to engineering degree courses. Within the debate, much of the commentary takes a very narrow viewpoint and does not benefit from international comparisons and experienced international practice benchmarking. This paper lists some of the important linked issues and problems which require to be tackled simultaneously to improve the consistency, quality and balance of engineering education to better meet the needs of industry and the individual, including his/her cultural and transferable personal-skill needs. Using international comparisons and contemporary views of the skills required of engineers in practice, it discusses a possible shortlist of actions that need to be applied urgently and simultaneously to achieve a practical solution to the problems.
Macrolide Antibiotics: Binding Site, Mechanism of Action, Resistance (2003)

Macrolides are among the most clinically important antibiotics. However, many aspects of macrolide action and resistance remain obscure. In this review we summarize the current knowledge, as well as unsolved questions, regarding the principles of macrolide binding to the large ribosomal subunit and the mechanism of drug action. Two mechanisms of macrolide resistance, inducible expression of Erm methyltransferase and peptide-mediated resistance, appear to depend on specific interactions between the ribosome-bound macrolide molecule and the nascent peptide. The similarity between these mechanisms and their relation to the general mode of macrolide action is discussed and the discrepancies between currently available data are highlighted.
Congenital heart disease and heart failure. (2008)

The syndrome of heart failure in adult non-congenital heart disease patients includes myocardial disease and ventricular dysfunction. In the presence of congenital abnormalities the cause of heart failure is often multi-factorial and can be a result of the underlying anomaly, surgical intervention, or ventricular dysfunction. Despite the possible clinical similarities, the two conditions are fundamentally different. In congenital heart disease the neurohormonal system is already abnormal even in the absence of clinical manifestations of heart failure and, in many cases, exercise intolerance is related to cyanosis. The approach to heart failure management in the two etiologies might be similar. Preventative attempts to preserve ventricular function in coronary or valve disease parallels early reparative therapy in congenital heart disease Pharmacological therapy is common for the two conditions, despite the limited number of evidence-based recommendations for congenital diseases. In drug-resistant patients, cardiac electrical resynchronization is an established therapy for treating ventricular asynchrony in non-congenital heart failure sufferers, but has only recently been adopted in selected congenital cases. Due to this, congenital heart disease patients are managed in highly specialized unites in close cooperation with cardiologists and surgeons. The ideal follow-up protocol for such patients remains to be determined, particularly in those individuals with subclinical signs of residual cardiac dysfunction. Heart Fail Monit 2008;6(1):2-8.
Reentrant Antiferroelectric Phase in 4-(1-Methylheptyloxycarbonyl) phenyl 4'-Octylbiphenyl-4-Carboxylate (1992)

The presence of three phases was found between SmA and the antiferroelectric SmC A * phase in optically active ( R )-4-(1-methylheptyloxycarbonyl)phenyl 4'-octylbiphenyl-4-carboxylate. Two of these phases were identified as SmC α * and SmC γ * by the miscibility test. The remaining phase between these was confirmed to be another antiferroelectric phase from dielectric measurement and conoscopic observation. Thus, antiferroelectric order appears at least three times: SmC α * , the new antiferroelectric phase and SmC A * . The new antiferroelectric phase is different from the SmC A * phase in that it exhibits much lower stability against an electric field.
A New Approach to Interactive Grasping Simulation of Product Concepts in a Virtual Reality Environment (2007)

Customer evaluation of concepts plays an important role in the design of handheld devices, such as bottles of douche gels and shampoos, where the phenomenon of grasping needs to be evaluated. In these applications important information on the aspects of ergonomics and user behaviors could be gathered from computer simulation. It is our ultimate goal to develop an environment in which users and designers can freely interact with product concepts. In our approach to grasping simulation there is no tactile feedback and we do not measure the exerted grasping forces. There is no wiring of the human hand, and the users are not limited in their movements. We measure the motion of the human hand, compute the grasping forces based on anthropometric data, and simulate the reaction of product concepts in a physically based virtual reality environment. Our contribution consists of: (i) a method, which takes into account the anatomy of the human hand in order to determine the maximum grasping forces, and (ii) an approach which enables to control the grasping forces based on (a) the penetration of the virtual human hand into the virtual model of product concept (b) the posture of the grasping, and (c) the angles of the joints. The paper reports on the framework of our approach and presents an application.
Bioorganometallic fulvene-derived titanocene anti-cancer drugs (2008)

6-Substituted fulvenes are interesting and easily accessible starting materials for the synthesis of novel substituted titanocenes via reductive dimerisation, carbolithiation or hydridolithiation reactions, which are followed by a transmetallation reaction with titanium tetrachloride in the latter two cases. Depending on the substitution pattern, these titanocenes prove to be bioorganometallic anti-cancer drugs, which have significant potential against advanced or metastatic renal-cell cancer. Patients bearing these stages of kidney cancer have a poor prognosis so far and therefore real progress in the area of metal-based anti-cancer drugs may come from this simple and effective synthetic approach. This tutorial review provides an insight into the synthesis of fulvene-derived titanocenes and their activity in preclinical experiments.