gebhart/patrepeval huggingface dataset:
Circadian rhythms in human salivary flow rate and composition (1972)

1. Unstimulated whole saliva and parotid saliva stimulated at a constant flow rate of 1.0 ml./min were collected from eight subjects at about 07.00, 11.00, 14.00, 17.00 and 22.00 hr and oral temperature was recorded several times daily for time spans of between 4 and 26 days. A least-squares cosine wave was fitted to the data to test for the presence and characteristics of circadian rhythms.2. Estimates of mean level, amplitude, acrophase and period were obtained for different components and the results were subjected to cosinor analysis.3. Unstimulated whole saliva showed significant circadian rhythms in flow rate and in the concentrations of sodium and chloride but not in protein, potassium, calcium, phosphate or urea.4. Stimulated parotid saliva showed significant circadian rhythms in the concentrations of protein, sodium, potassium, calcium and chloride but not in phosphate or urea5. Oral temperature showed a circadian rhythm which, like the salivary rhythms, was of a 24.0 hr periodicity.
Sequential Monte Carlo inference of internal delays in nonstationary data networks (2002)

On-line, spatially localized information about internal network performance can greatly assist dynamic routing algorithms and traffic transmission protocols. However, it is impractical to measure network traffic at all points in the network. A promising alternative is to measure only at the edge of the network and infer internal behavior from these measurements. We concentrate on the estimation and localization of internal delays based on end-to-end delay measurements from a source to receivers. We propose a sequential Monte Carlo (SMC) procedure capable of tracking nonstationary network behavior and estimating time-varying, internal delay characteristics. Simulation experiments demonstrate the performance of the SMC approach.
Determination of the in situ bactericidal activity of an essential oil mouthrinse using a vital stain method (2000)

This study confirms the findings of previous in vitro and in vivo studies which demonstrated the essential oil mouthrinse to have significant biocidal activity against oral micro-organisms. These studies all support the primacy of a bactericidal mechanism in producing the plaque and gingivitis reductions observed in numerous clinical trials conducted on the essential oil mouthrinse.
Chapter 4: Labor and Employment Law (1981)

Significant judicial and legislative developments in Massachusetts labor and employment law occurred during 198-1.On the legislative front, several statutes affecting labor relations agencies were enacted!The Board of Conciliation and Arbitration (the "Board") was removed from the jurisdiction of the Department of Labor and Industries and was established as an independent agency.The Board's chairman has authority to promulgate rules and regulations, and to make appointments on a case by case basis to carry out the purposes of the agency. 2Although it will continue to operate autonomously, the Joint Labor Management Committee (the "Joint Committee") was made a part of the Board. 3 This organizational change enables employees of the two agencies to be interchanged when such is warranted to efficiently and expeditiously deal with particular labor disputes.'There were several significant amendments to chapter 150E of the General Laws, the statute which governs public employee collective bargaining in Massachusetts.The decisions of the Massachusetts Labor Relations Commission (the "Commission") are now reviewable directly by the Massachusetts Appeals Court, removing the superior court from the appellate process. 5 Another amendment permits the Commission to refer "refusal to bargain" cases to either the Board or the Joint Committee for mediation. 6 Finally, an amendment to section 11 of chapter 150E, sets forth the standards for issuing complaints in unfair labor practice cases. 7 A separate enactment amended the definition of "public employer" in section 1 of chapter 150E. 1
Zernike Annular Polynomials and Optical Aberrations of Systems with Annular Pupils (1994)

Zernike annular polynomials that represent orthogonal andbalanced aberrations suitable for systems with annular pupilsare described. Their numbering scheme is the same asfor Zernike circle polynomials. Expressions for standard deviationof primary and balanced primary aberrations are given.
A high density 0.10 μm CMOS technology using low K dielectric and copper interconnect (2002)

In this work components of the next generation 0.10 /spl mu/m CMOS technology are presented. They form the core of a platform encompassing logic, non volatile memory, and analog blocks. High performance bulk devices use 18 /spl Aring/ gate oxide (24 /spl Aring/ inversion Tox) while low power devices use 25 /spl Aring/ gate oxide (31 /spl Aring/ inversion Tox) for reduced gate leakage. Gate lengths range from 65 nm for the high performance devices to 90 nm for the low power devices. Both 3.3 V and 2.5 V I/Os are supported using 70 /spl Aring/ and 50 /spl Aring/ oxide devices. The backend employs low-k (k/spl sim/3) dielectric with multiple levels of Cu metallization. The high density 6T SRAM cell size is 1.33 /spl mu/m/sup 2/.
Quantifying the distributions of dislocation spacings and cell sizes (2008)

A new method is proposed to quantify the local dislocation spacings on sections displaying the intersections of dislocation lines. The method was applied to dislocation structures in single crystals of CaF2 introduced by deformation at elevated temperature and made visible by etch pits. The method yields the frequency distributions and the spatial distributions of dislocation spacings. For cellular dislocation structures the method provides a quantitative and objective characterization in terms of frequency distribution of dislocation spacings in cell boundaries and cell interiors and of cell size.
Randomized, double-blind, placebo-controlled crossover trial of modafinil in the treatment of excessive daytime sleepiness in narcolepsy (1997)

Seventy-five patients meeting international diagnostic criteria for narcolepsy enrolled in a 6-week, three-period, randomized, crossover, placebo-controlled trial. Patients received placebo, modafinil 200 mg, or modafinil 400 mg in divided doses (morning and noon). Evaluations occurred at baseline and at the end of each 2-week period. Compared with placebo, modafinil 200 and 400 mg significantly increased the mean sleep latency on the Maintenance of Wakefulness Test by 40% and 54%, with no significant difference between the two doses. Modafinil, 200 and 400 mg, also reduced the combined number of daytime sleep episodes and periods of severe sleepiness noted in sleep logs. The likelihood of falling asleep as measured by the Epworth Sleepiness Scale was equally reduced by both modafinil dose levels. There were no effects on nocturnal sleep initiation, maintenance, or architecture, nor were there any effects on sleep apnea or periodic leg movements. Neither dose interfered with the patients' ability to nap voluntarily during the day nor with their quantity or quality of nocturnal sleep. Modafinil produced no changes in blood pressure or heart rate in either normotensive or hypertensive patients. The only significant adverse effects were seen at the 400-mg dose, which was associated with more nausea and more nervousness than either placebo or the 200-mg dose. As little as a 200-mg daily dose of modafinil is therefore an effective and well-tolerated treatment of excessive daytime somnolence in narcoleptic persons.
Learning a Complete Image Indexing Pipeline (2018)

To work at scale, a complete image indexing system comprises two components: An inverted file index to restrict the actual search to only a subset that should contain most of the items relevant to the query; An approximate distance computation mechanism to rapidly scan these lists. While supervised deep learning has recently enabled improvements to the latter, the former continues to be based on unsupervised clustering in the literature. In this work, we propose a first system that learns both components within a unifying neural framework of structured binary encoding.
Efficient Cell-Aware Fault Modeling by Switch-Level Test Generation (2016)

This paper proposes methods to drastically reduce the expensive analog fault simulation currently used to create cell-aware fault models. By exploiting low-power properties of common CMOS designs, most defects in the transistor-level netlist containing parasitics can be represented by just two canonical fault classes. Via simple circuit analysis, we show that faulty behaviors are completely predictable as the defect resistance parameter value varies from zero to infinity, thus eliminating the need for circuit simulation at multiple parameter values. The two canonical fault classes can be modeled by transistor switch stuck-open and stuck-closed faults. Rather than enumerating the full combination cell input patterns to search for defect detection conditions by analog fault simulation, switch-level test generation can obtain those input conditions directly, thereby reducing significantly the role of analog simulation to that of ranking conditions in terms of detection effectiveness.
Laboratory assessment of hepatic injury in the woodchuck (Marmota monax). (1985)

Normal reference values for total serum protein, albumin, cholesterol, alanine aminotransferase (ALT), aspartate aminotransferase (AST), sorbitol dehydrogenase (SDH), gamma glutamyl transferase (GGT), alkaline phosphatase (AP), and total bilirubin were established in 48 clinically healthy woodchucks. To validate the use of these biochemical tests in the woodchuck for assessment of liver injury, carbon tetrachloride was administered to produce hepatocellular necrosis and the common bile duct was surgically occluded to produce cholestasis. Biochemical tests were performed prior to experimental treatment and thereafter in surviving woodchucks for a period of 6 weeks. There were marked increases in the serum activities of AST, ALT, and SDH following carbon tetrachloride administration and all 3 enzymes appeared to be useful markers of acute hepatocellular injury. The predominate biochemical abnormalities in woodchucks with bile duct obstruction were hyperbilirubinemia, hypercholesterolemia and increased serum AP and GGT activities. The increase of GGT occurred earlier following bile duct obstruction and the magnitude of increase was greater than that of AP, suggesting that GGT would be the preferred serum enzyme test in the woodchuck for assessment of cholestatic liver injury.
Comparison of the sensitivity of the caudal fold skin test and a commercial gamma-interferon assay for diagnosis of bovine tuberculosis. (1995)

A study to determine and compare the sensitivity of the caudal fold tuberculin test (CFT) and a commercial gamma-interferon (gamma-IFN) assay for diagnosis of bovine tuberculosis was conducted. A dairy herd with approximately a third of the cattle infected with Mycobacterium bovis was chosen for this study. All cattle from this herd were slaughtered, and tissue specimens for bacteriologic culturing and histologic examination were collected. Results of the CFT and gamma-IFN assay were compared with results of bacteriologic culturing and histologic examination to determine test sensitivity. Results were analyzed, using each of the following 4 standards to classify cattle as infected: positive test result by bacteriologic culturing only; histologic examination only; bacteriologic culturing and histologic examination; and bacteriologic culturing or histologic examination. Sensitivity of the CFT ranged from 80.4 to 84.4%, depending on the standard of comparison. Sensitivity of the gamma-IFN assay ranged from 55.4 to 97.1%, depending on the standard of comparison and on the method of interpretation. The CFT was significantly (P < 0.001) more sensitive than the gamma-IFN assay for diagnosis of bovine tuberculosis when the gamma-IFN assay was conducted and interpreted as instructed by the manufacturer. Maximum overall sensitivity was achieved when results of the CFT and gamma-IFN assay were interpreted in parallel.
Microbiology and Chemistry of Fermented Fish (1966)

SUMMARY The microbiology and chemistry of Thai fish sauce was investigated in relation to the development of flavor and aroma. Total viable count decreased steadily as fermentation time advanced. The counts were higher when media containing 10% NaCl were used than when media containing 0.5% NaCl were used. Approximately 70% of the bacterial isolates from a nine‐month‐old fish sauce were halophiles of Bacillus types. These bacteria produced volatile acids from cultures in a medium prepared by hydrolyzing rockfish (Sebastodes sp.) with a mineral acid. A diethyl‐ether‐ethanol‐soluble fraction contained the typical aroma of fish sauce. This extract could be separated further by column chroma tography (AGl‐X8, formate form) into a fraction containing amino compounds and a second fraction containing weakly acidic compounds. The amino acids, principally glutamic acid, histidine, proline, etc., and other amines were identified by thin‐layer chromatography. The identification of acidic compounds has not been completed.
Intrapleural administration of tumour necrosis factor‐alpha (TNFα) in patients with mesothelioma: cytokine patterns and acute‐phase protein response (2000)

In the setting of a phase I study of repetitive intrapleural administration of TNFalpha in mesothelioma patients, we studied the characteristics of the inflammatory response. Intrapleural administration was followed by a clear inflammatory response locoregionally. In spite of TNFalpha peak levels as high as 700 ng mL-1 systemic levels were never detectable. The secondary cytokine response led to very high intrapleural IL-6 and IL-8 levels. Systemically IL-8 levels were never detectable whereas high IL-6 levels were induced systemically initially, with a decreased response to each intrapleural TNFalpha administration over time. The acute-phase response in contrast remained remarkably constant throughout the course of repeated intrapleural administrations of TNFalpha. Intrapleural administration of TNFalpha is well tolerated but associated with inconsistent and rather moderate impact on production of pleural fluid. This can be achieved by other simpler and cheaper treatment, thus we see no justification for further studies.
DETERMINATION OF FRACTURE TOUGHNESS OF HEAT TREATED AISI D2 STEEL USING FINITE ELEMENT AND ACOUSTIC EMISSION METHODS (2015)

The AISI D2 steel is a high-chromium and high-carbon tool steel which has good mechanical properties such as high compressive strength and good through-hardening. Despite these advantages, fracture toughness of this steel is moderate. In this study, fracture toughness of AISI D2 steel was determined using Finite Element and Acoustic Emission methods. Selected steel (AISI D2 cold-work tool steel) was heat treated and tempered at different conditions. Then Compact testing specimens were prepared according to ASTM E399 standard and fracture toughness of the specimens was specified according to the standard method. The specimens were modeled in the commercial FE software (ABAQUS) and fracture toughness of the specimens was determined using FEM. Determination of fracture toughness using AE technique was carried out according to three methods: Acoustic Emission Energy Rate (AEER), Acoustic Emission Count Rate (AECR) and integral of sentry function. The results obtained from ASTM E399, Finite Element and Acoustic Emission methods were compared with each other. It was found that fracture toughness values which were obtained using AECR and integral of sentry function techniques are lower bound and the results obtained from FEM are upper bound values of the fracture toughness. Furthermore, fracture toughness values obtained using AEER were the most consistent with the results obtained from ASTM E399 standard method. Finally, it could be concluded that Acoustic Emission method can be used as a useful method for determination of fracture toughness of engineering materials.
Optimization of (2,3-Dihydro-1-benzofuran-3-yl)acetic Acids: Discovery of a Non-Free Fatty Acid-Like, Highly Bioavailable G Protein-Coupled Receptor 40/Free Fatty Acid Receptor 1 Agonist as a Glucose-Dependent Insulinotropic Agent (2012)

G protein-coupled receptor 40 (GPR40)/free fatty acid receptor 1 (FFA1) is a free fatty acid (FFA) receptor that mediates FFA-amplified glucose-stimulated insulin secretion in pancreatic β-cells. We previously identified (2,3-dihydro-1-benzofuran-3-yl)acetic acid derivative 2 as a candidate, but it had relatively high lipophilicity. Adding a polar functional group on 2 yielded several compounds with lower lipophilicity and little effect on caspase-3/7 activity at 30 μM (a marker of toxicity in human HepG2 hepatocytes). Three optimized compounds showed promising pharmacokinetic profiles with good in vivo effects. Of these, compound 16 had the lowest lipophilicity. Metabolic analysis of 16 showed a long-acting PK profile due to high resistance to β-oxidation. Oral administration of 16 significantly reduced plasma glucose excursion and increased insulin secretion during an OGTT in type 2 diabetic rats. Compound 16 (TAK-875) is being evaluated in human clinical trials for the treatment of type 2 diabetes.
Applications of Web-based workflow (2002)

A Web-based workflow system was developed at the Jet Propulsion Laboratory and several pilot applications were developed. The authors give an overview of the architecture and functionality of the workflow system, describe three pilot workflows that have been or are being deployed, and relate lessons learned.
Reaction Conditions Study in Linear H-Functional Polysiloxane Synthesis (1998)

Abstract A reaction conditions study in the synthesis of methyl-hydropolysiloxanes was proposed taking into account the variation of some parameters, such as conversion, amount of active hydrogen, intrinsic viscosity, molecular weight versus the reaction time, amount of catalyst and reaction temperature. Methylhydropolysiloxanes were obtained using a bulk heterogeneous polymerization-equilibration reaction of octamethyl-cyclotetrasiloxane (D4), linear methylhydrosiloxane (L-31) and hexamethyl-disiloxane (HMDS), in the presence of styrene-divinylbenzene sulfonic acid copolymer (VIONI-CS-34C) as catalyst. Key Words: H-polysiloxanesHeterogeneous ReactionEquilibrationCopolymers
Nod2-Dependent Regulation of Innate and Adaptive Immunity in the Intestinal Tract (2005)

The gene encoding the Nod2 protein is frequently mutated in Crohn's disease (CD) patients, although the physiological function of Nod2 in the intestine remains elusive. Here we show that protective immunity mediated by Nod2 recognition of bacterial muramyl dipeptide is abolished in Nod2-deficient mice. These animals are susceptible to bacterial infection via the oral route but not through intravenous or peritoneal delivery. Nod2 is required for the expression of a subgroup of intestinal anti-microbial peptides, known as cryptdins. The Nod2 protein is thus a critical regulator of bacterial immunity within the intestine, providing a possible mechanism for Nod2 mutations in CD.
Effects of hormones and protein kinase inhibitors on expression of steroidogenic enzyme promoters in electroporated primary rat granulosa cells (1996)

Previous studies have shown that inhibitors of protein tyrosine kinases, tyrphostins, can markedly attenuate the steady-state levels of mRNAs of hormone-induced genes expressed in ovarian cells. To further elucidate the mechanism of tyrphostin action, rat granulosa cells were electroporated with chimeric expression vectors containing the promoters of two key steroidogenic genes, cholesterol side chain cleavage cytochrome P450 (CYP11A; P450scc) and aromatase cytochrome P450 (CYP19; P450arom), ligated to the CAT reporter gene. The electroporation method of transfection documents that the respective promoter-reporter constructs, -379sccCAT and -534aromCAT, can confer greater than 10-fold FSH/cAMP responsiveness to the reporter genes expressed in naive granulosa cells. Furthermore, the electroporation approach allows transfection of DNA into small numbers of cells and facilitates the assay of expression in cells isolated from follicles at advanced stages of differentiation. In naive granulosa cells, the functional activities of -379sccCAT, -534aromCAT, and -169 alpha CGCAT were abolished by the A-kinase specific inhibitor, H89, supporting the notion that activation of protein kinase A is obligatory for transcriptional activation of the promoter regions within these genes. Similar inhibitory effects were also observed for tyrphostin AG18, thus implicating a tyrosine kinase in the regulation of the steroidogenic genes. As a result of eCG/hCG treatments, a gradual loss of transfection efficiency accompanied by decreasing forskolin induction of CAT expression was observed in the differentiating granulosa-lutein cells. Although the reason(s) for the apparent loss in the ability of hormones to regulate chimeric gene expression remains to be determined, cell and promoter refractoriness to hormone treatment appears to reflect a fundamental change in the mechanism of promoter activation in the differentiated cells compared to the naive granulosa cells.
Identification of the First Nonpeptidergic Inverse Agonist for a Constitutively Active Viral-encoded G Protein-coupled Receptor (2003)

Human cytomegalovirus (HCMV) encodes a G protein-coupled receptor (GPCR), named US28, which shows homology to chemokine receptors and binds several chemokines with high affinity. US28 induces migration of smooth muscle cells, a feature essential for the development of atherosclerosis, and may serve as a co-receptor for human immunodeficiency virus-type 1 entry into cells. Previously, we have shown that HCMV-encoded US28 displays constitutive activity, whereas its mammalian homologs do not. In this study we have identified a small nonpeptidergic molecule (VUF2274) that inhibits US28-mediated phospholipase C activation in transiently transfected COS-7 cells and in HCMV-infected fibroblasts. Moreover, VUF2274 inhibits US28-mediated HIV entry into cells. In addition, VUF2274 fully displaces radiolabeled RANTES (regulated on activation normal T cell expressed and secreted) binding at US28, apparently with a noncompetitive behavior. Different analogues of VUF2274 have been synthesized and pharmacologically characterized, to understand which features are important for its inverse agonistic activity. Finally, by means of mutational analysis of US28, we have identified a glutamic acid in transmembrane 7 (TM 7), which is highly conserved among chemokine receptors, as a critical residue for VUF2274 binding to US28. The identification of a full inverse agonist provides an important tool to investigate the relevance of US28 constitutive activity in viral pathogenesis.
Tetrakis(trimethylsilyl)tetrahedrane (2002)

Tetrakis(trimethylsilyl)tetrahedrane 3 has been synthesized upon irradiation of tetrakis(trimethylsilyl)cyclobutadiene 8, which can be prepared either by thermal nitrogen elimination from trimethylsilyl[1,2,3-tris(trimethylsilyl)-2-cycloprop-1-enyl]diazomethane 7 or by mild oxidation of cyclobutadiene dianion 9 with 1,2-dibromoethane. The structural characterization of tetrahedrane 3 has been achieved by X-ray crystallography. The surprising thermal stability of 3 - which is stable up to 300 degrees C - is discussed.