gebhart/patrepeval huggingface dataset:
Antagonism of NMDA receptors as a potential treatment for Down syndrome: a pilot randomized controlled trial (2012)

Down syndrome (DS) is the most common genetic cause of intellectual disability. The N-methyl-D-aspartate (NMDA) receptor uncompetitive antagonist, memantine hydrochloride (memantine), has been shown to improve learning/memory and rescue one form of hippocampus synaptic plasticity dysfunction in the best-studied mouse model of DS available, the Ts65Dn mouse. Given the status of memantine as a treatment for Alzheimer's disease (AD) approved by the Food and Drug Administration, the preclinical evidence of potential efficacy in Ts65Dn mice, and the favorable safety profile of memantine, we designed a study to investigate whether the findings in the mouse model could be translated to individuals with DS. In this pilot, proof-of-principle study we hypothesized that memantine therapy would improve test scores of young adults with DS on measures of episodic and spatial memory, which are generally considered to be hippocampus dependent. Accordingly, in this randomized, double-blind, placebo-controlled trial, we compared the effect of 16-week treatment with either memantine or placebo on cognitive and adaptive functions of 40 young adults with DS using a carefully selected set of neuropsychological outcome measures. Safety and tolerability were also monitored. Although no significant differences were observed between the memantine and placebo groups on the two primary outcome measures, we found a significant improvement in the memantine group in one of the secondary measures associated with the primary hypothesis. Only infrequent and mild adverse events were noted.
Cadmium Telluride Nuclear Radiation Detectors (1975)

The characteristics and performance of undoped high resistivity cadmium telluride detectors are compared to chlorine compensated counters. It is shown, in particular, that "undoped" CdTe Is in fact aluminium doped and that compensation occurs, as in silicon or germanium, by pair and triplet formation between the group III donor and the doubly charged cadmium vacancy (Vcd) acceptor. Furthermore, in chlorine doped samples, the polarization effect results from the unpaired (Vcd) level at Ec -0. 6 eV.
LIZA: an extensible groupware toolkit (1989)

Software for supporting groups of cooperating users — groupware — raises a number of new issues in user interface design. This paper gives a definition of groupware and presents a model of group tools based on active objects. The model has been applied to the design and implementation of an extensible groupware toolkit known as LIZA. The paper describes the architecture of LIZA. Examples of group tools running under LIZA are used to illustrate some of the problems in the design of multi-user interfaces.
Scalable Self-Adaptive Synchronous Triggering System in Superconducting Quantum Computing (2018)

Superconducting quantum computers (SQC) can solve some specific problems which are deeply believed to be intractable for classical computers. The control and measurement of qubits can't go on without the synchronous operation of digital-to-analog converters (DAC) array and the controlled sampling of analog-to-digital converters (ADC). In this paper, a scalable self-adaptive synchronous triggering system is proposed to ensure the synchronized operation of multiple qubits. The skew of the control signal between different qubits is less than 25 ps. After upgrading the clock design, the 250 MHz single-tone phase noise of DAC has been increased about 15 dB. The phase noise of the 6.25 GHz qubit control signal has an improvement of about 6 dB.
Anti-Inflammatory Actions of Pentacyclic Triterpenes (1997)

Pentacyclic triterpenes (PTs) as aglycones of saponins have a wide distribution in plants, and many of them have been used as anti-inflammatory remedies in folk medicine. This survey critically reviews the effects of PTs on proinflammatory mediator signalling pathways and data from experimental animal models and clinical trials. Because the knowledge of their actions is far from being satisfactory a critical summary of the partly promising but mostly scattered and preliminary data might promote productive research on chances and risks of PTs. Antiproliferative and anti-infectious actions and effects on intracellular cell signalling and hormone metabolism are beyond the scope of this short review, although such effects might also contribute to the understanding of the systemic anti-inflammatory actions of aglycones.
An optimal scheduling scheme for tiling in distributed systems (2007)

There exist several scheduling schemes for parallelizing loops without dependences for shared and distributed memory systems. However, efficiently parallelizing loops with dependences is a more complicated task. This becomes even more difficult when the loops are executed on a distributed memory cluster where communication and synchronization can be a bottleneck. The problem lies in the processor idle time which occurs during the beginning and final stages of the execution. In this paper we propose a new scheduling scheme that minimizes the processor idle time and thus it enhances load balancing and performance. The new scheme is applied to two-dimensional iteration spaces with dependences. The proposed scheduling scheme follows a tiled wavefront pattern in which the tile size gradually decreases in all dimensions. We have tested the proposed scheme on a dedicated and homogeneous cluster of workstations and we verified that it significantly improves execution times over scheduling using traditional tiling.
THE FRAMINGHAM EYE STUDY (1977)

During the period 1973--1975, 2675 out of 3977 still-living members of the Framingham, Massachusetts, study population, who have been under investigation for coronary disease risk factors since 1948 and who were in 1973--1975 aged 52 to 85, were given an eye examination stressing cataract, diabetic retinopathy, macular degeneration and glaucoma. Of 2940 subjects who still lived in the local Framingham area, 2477 were examined. Local population prevalence for one or both eyes positive was: 15.5% for senile cataract, 3.1% for diabetic retinopathy, 8.8% for senile macular degeneration and 3.3% for open-angle glaucoma. The proportion of adults with poor "best" visual acuity may be much less than has been estimated by the National Health Survey and the proportion with open-angle glaucoma much more than currently suspected on the basis of foreign studies.
Practical development of genetically engineered animals as human disease models. (1997)

Since transgenic (Tg) mice were first produced in 1980, the technology to produce genetically engineered animals, such as Tg and knock-out mice, has advanced exponentially. These animals have contributed greatly to basic research at the molecular level and have proven to be powerful tools for elucidating complex biological processes. The effort that is required to develop and establish genetically engineered animals as models for human diseases or toxicologic studies is not always appreciated by researchers and laboratory animal scientists. Genetically engineered animals remain only candidates of defined animal models until they are developed for practical use, in accordance with their objectives, through cooperation between the researchers performing the experiments and laboratory animal scientists. The practical development of these animals consists of three steps: establishment as standardized laboratory animals through the setting of quality standards and the establishment of a production and supply system; establishment as defined animal models through confirmation of the usefulness and limitations of the animal in the purpose of use; and establishment of an in vivo experimentation system (an animal experimentation system), using the defined animal models. This report serves as an introduction to those that follow and describes our concept of how best to establish genetically engineered animals as valid animal models. The development of Tg mice carrying the poliovirus receptor gene (PVR) will be used as an example. The TgPVR mice were produced by the introduction of the human poliovirus receptor gene into the mouse genome, mainly to study the molecular mechanisms of pathogenesis of the virus. The value of these mice is that they mimic human and nonhuman primate susceptibility to poliovirus infection and thus serve as a model for the study of the disease and for the assessment of poliovirus vaccines. They are being touted as a replacement for nonhuman primates in the neurovirulence testing of oral poliovirus vaccine.
The exact solution of the time-harmonic wave equation for a linear velocity profile (2006)

We present the exact solution of the acoustic wave equation in the frequency domain in two space dimensions for a velocity that increases linearly with depth and a density that is a power law in depth. The geometric properties of the solution are described by the bipolar coordinate system. The asymptotic behaviour for large frequencies matches the result obtained by ray theory. The 3-D solution was already known.
Antibody response to Haemophilus influenzae type b tetanus conjugate vaccine with two doses given at 3 and 5 months of age (2002)

These results indicate that two doses of PRP-T can induce high antibody titers using the proposed schedule; moreover, the GMT assessed at 15 months of age was also protective. The enhanced immune response observed in the study could be explained by the previous administration of the DTP vaccine, since the longer the interval between DTP and PRP-T, the better the response to Hib vaccine. The PRP-T vaccine given at 3 and 5 months of age may be an economical alternative to the current proposed schedule, which could make the introduction of Hib vaccination in developing countries more feasible, considering the relatively high cost of this vaccine.
Techniques for the routine on-line processing of the fetal electrocardiogram (1986)

In order to routinely monitor the fetal electrocardiogram (FECG), during labor, in an on-line real-time situation, the following processes need to be undertaken: The FECG signal must be recovered from noise. The recovered signal or waveform must be measured with a high degree of precision in order to generate the timing intervals, areas and parameters that are of interest to the clinician. The FECG and measured parameters must be presented to the clinician in a meaningful and simple format. Control of the machine and its processing should be a user friendly operation. In the current work, a system is described that uses digital filtering to recover the FECG waveform from low frequency biological noise and associated artifacts. A linear model of the FECG waveform is used to evaluate some 18 different timing intervals of the FECG. The enhanced waveform and accompanying parameters are displayed upon an intelligent graphics terminal to achieve a user friendly operation of the system by clinical staff.
A Practical Method for Automatic Real-Time EEG Sleep State Analysis (1980)

A computer system for real-time analysis of the electroencephalograph (EEG) is described. The system performs continuous analysis, with graphic, analog, and tabular outputs, and storage of selected samples on disk for off-line analysis. Implemented mostly in high-level software, it is based on a two-component model of the signal in which waves are detected by a combination zero-crossing and peak detection algorithm. Each sample is classified by a pattern recognition scheme into one of several classes on the basis of the frequency distribution of waves; the classes correspond to normal sleep-awake states. Samples are taken ten times per minute and tabulated once per minute to provide a concise quantified history which is well suited to long-term EEG studies. Alternate independent information channels allow verification of results. Samples stored on disk may be grouped and averaged for statistical comparisons of EEG signal characteristics. The state classification algorithm has been tailored to the EEG of the cat; the results of a series of 7-8 day sleep studies are presented.
Combinatorial strategy targets new materials (1995)

RETURN TO ISSUEPREVNewsNEXTCombinatorial strategy targets new materialsSTU BORMANCite this: Chem. Eng. News 1995, 73, 26, 7Publication Date (Print):June 26, 1995Publication History Published online12 November 2010Published inissue 26 June 1995https://pubs.acs.org/doi/10.1021/cen-v073n026.p007https://doi.org/10.1021/cen-v073n026.p007newsACS PublicationsCopyright © 1995 AMERICAN CHEMICAL SOCIETYArticle Views6Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options SUBJECTS:Biomaterials Get e-Alerts
P‐42: Design and Implementation of PDP Driving System Based on Irregular Addressing Scheme (1998)

Abstract 160 × 120 monochrome double‐substrate AC‐PDP was successfully operated with 64 gray scale irregular addressing to result in the 3‐fold luminance improvement over the conventional sequential addressing. The details of design and implementation of PDP driving system is described with the experimental results. It is shown that the irregular addressing scheme can be implemented using the existing PDP driver ICs with the minimal overhead in logic design complexity.
A Gene-Networked Gel Matrix-Supported Lipid Bilayer as a Synthetic Nucleus System (2012)

A spheroidal transgene-networked gel matrix was designed as a synthetic nucleus system. It was spheroidically manufactured using both advanced lithography and DNA nanotechnology. Stable Aqueorea coerulescens green fluorescent protein (AcGFP)-encoding gene cross-networks have been optimized in various parameters: the number of gene-networked gel (G-net-gel) spheroids, the concentration of a AcGFP plasmid in the scaffold, and the molar ratio between the X-DNA building blocks and the gene. It was then assessed that 800 units of the gene networked gel matrix at a 4000:1 molar ratio of X-DNA blocks and AcGFP gene components accomplished 20-fold enhanced in vitro protein expression efficiency for 36 h. Furthermore, once with lipid capping, it reproduced the natural nucleus system, demonstrating the 2-fold increased levels of messenger RNAs (mRNAs) relative to solution phase vectors.
Control of Cercospora leaf spot of sugar beet with ultra-low-volume oil-based fungicidal mists (1965)

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The safety and efficacy of tooth bleaching: a review of the literature 1988-1990. (1991)

Two hundred fifty-six major medical and dental journals were searched, and a comprehensive study was completed on the chemistry of hydrogen peroxide and carbamide peroxide. The results indicate that safety and efficacy of hydrogen peroxide is well established, while carbamide peroxide is much more complicated and no long-term safety studies are available for tooth bleaching using carbamide peroxide.
In-Line Hydrocarbon Adsorber System for ULEV (1996)

<div class="htmlview paragraph">An In-line hydrocarbon (HC) adsorber system was developed to reduce cold start HC emissions. The system comprises a first catalyst, adsorber unit, and a second catalyst for oxidation of desorbed HC. During cold start, exhaust gas is directed to the hydrocarbon adsorber using a fluidic flow diverter unit without any mechanical moving parts in the exhaust system. After the first catalyst lights off, the diverter is shut off and the major portion of the exhaust gas then flows directly to the second catalyst without heating the adsorber unit. After the second catalyst reaches light-off temperature additional air was added to oxidize the desorbed HC.</div> <div class="htmlview paragraph">The system attributes:</div> <div class="htmlview paragraph">NMHC emissions in ULEV range Straight line axial flow Reliable design Limited back pressure penalty The system was tested on a 3.8L U.S. vehicle.</div>
Small-molecule inhibitors of HIF-PHD2: a valid strategy to renal anemia treatment in clinical therapy (2016)

Patients with chronic kidney diseases (CKD) always suffer from anemia with severe impacts on their quality of life.
A novel design method of the impact zone of a high-speed train (2020)

The design of vehicle impact zone is of great significance for passive safety protection of trains. This study introduces a novel design method of impact zone based on the concept of linear impact force, which has a linear increase of impact force with the increase of displacement. A three-dimensional dynamic model of train collision was constructed and validated. Here, the linear impact force slope of energy absorbing devices were selected as design variables, whereas the total mean acceleration along the train (TMA) and the total crash displacement (TS) were set as objectives. The multi-objective particle swarm optimisation was used to seek for an optimal design of the impact zone, where the response surface method was adopted to formulate the TMA and TS. The results indicate that the optimised design has smaller impact acceleration peak value, higher utilisation efficiency of compression stroke, and more uniform distribution of crashing displacement.
Single pump on‐line mixing system for capillary supercritical fluid chromatography (1993)

Abstract A simple inexpensive system comprising a piston pump, switching valves, and capillary tubing has been developed for preparing mixed mobile phases for capillary supercritical fluid chromatography. The system enables the on‐line preparation of mixed mobile phases without contamination of the pump with modifier. Modifier concentrations, which can be changed stepwise, were determined both experimentally and theoretically, the latter on the basis of density–viscosity relationships. Examples of both isobaric and pressure programmed separations are demonstrated.
Where is APC going? (2001)

Adenomatous polyposis coli (APC) protein has been thought to function as a tumor suppressor through its involvement in the Wnt/beta-catenin signaling pathway. However, its connections to the cytoskeleton and microtubules in particular are becoming apparent, and the discovery of these new functions for APC is leading to a reevaluation of its role not only in tumorigenesis, but also in normal physiology.
The connection of the style of interactions and the collaboration in a virtual work environment (2015)

Nowadays it is becoming common for more and more people to work remotely in an online virtual space. Even the virtual presence of the partner means a difference in quality when engaged in a cooperative task. The purpose of this paper is to analyze social interactions in a virtual workspace. Earlier researches about the psychological features of online, remote, and virtual collaborations are also summarized. The research task replicates the process of creating an interesting holiday plan for tourists visiting Budapest. In the virtual tourist office, there are posters and a map available for the participants to create a feasible schedule for two days. The research was conducted in the VirCA (3D Virtual Collaboration Area), and includes a total of 12 analyses of dialogs recorded during the task. In completion of that, the participants' prior experiences and subjective impressions of the experiment are also measured. The efficiency of task output as a quality measure was compared with the dialogs' content analysis. The task completion time showed a strong positive correlation with the utterance category of coordination and also showed a strong but negative correlation with utterances of information sharing. The assertiveness had no connection with the efficiency index number, which was calculated by us. Results may provide a solid basis to gain better insight into the question of designing and planning task- and goal-specific communication. Conclusions may also bring guidance on how to use the virtual space more efficiently, making it more productive to collaborate.
Studies on the neuroleptic benzamides. III: Synthesis and antidopaminergic properties of new 3-nortropane derivatives (1984)

Synthese de tropanes et alkyl- ou arylmethyl-8 nortropanes substitues en 3 par [amino-2 methoxy-4- ou alkyl-2 alcoxy-4 pyrimidinecarbonyl-5 amino]. Pharmacologie
Two novel matrix proteins isolated from articular cartilage show wide distributions among connective tissues. (1986)

Two proteins of Mr = 58,000 and 59,000, respectively, were purified from 4 M guanidinium chloride extracts of articular cartilage by dissociative CsCl-density gradient centrifugation followed by gel chromatography on Sephadex G-200 and ion exchange chromatography on DEAE-cellulose. The two proteins differ in ionic properties and only the one with Mr = 59,000 bound to the ion exchanger. Although the two proteins showed dissimilar peptide patterns after proteolysis, their amino acid composition was similar, with very high contents of leucine and aspartic acid/asparagine. The two proteins showed no cross-reactivity in radioimmunoassays. By use of these assays, the proteins were demonstrated in extracts of most connective tissues, with high contents of about 0.1% of tissue wet weight determined in several types of cartilage. Among the non-cartilage connective tissues, tendon and sclera had the highest contents of the proteins, i.e. about 0.1% of the tissue wet weight. Bone extracts, on the other hand, contained insignificant amounts of the proteins. Only the Mr = 59,000 protein was detected in serum, its concentration being about 33 micrograms/l. Both proteins were shown to be localized in the extracellular matrix of cartilage, predominantly in the territorial matrix, by using indirect immunofluorescence.
A Proposed Comprehensive Grading System to Predict Outcome for Surgical Management of Intracranial Aneurysms (1998)

This new grading system is easy to apply, separates patients into groups with markedly different outcomes, and is comprehensive, allowing for more accurate prediction of surgical outcome for both unruptured and ruptured cerebral aneurysms.