gebhart/patrepeval huggingface dataset:
The MEK1 inhibitor PD98059 sensitizes C8161 melanoma cells to cisplatin-induced apoptosis (2001)

The regulation of apoptosis is believed to be dependent on the balance of the activities of different intracellular signalling systems. Activation of the SAPK/JNK pathway is implied in pro-apoptotic signalling, while activation of the MEK1/ERK pathway may have a viability-promoting effect. We show here that treatment with the MEK1 inhibitor PD98059 sensitizes the human melanoma cell line C8161 to cisplatin-induced apoptosis. In these cells, cisplatin at 40 microM did not elicit significant cell death, whereas massive cell death was seen when cells were pretreated for 20 h with 40 microM PD98059 before the addition of cisplatin. Concomitant addition of PD98059 and cisplatin did not have any sensitizing effect, and PD98059 on its own did not induce apoptosis. However, in three other human melanoma cell lines PD98059 did not potentiate cisplatin-induced apoptosis. Instead, in one of these cell lines (AA), PD98059 protected against cisplatin-induced cytotoxicity. We conclude that blocking of the MEK1/ERK pathway may, in some instances, potentiate the cytotoxic effect of cisplatin on human melanoma cell lines, whereas in other instances it may have a protective effect. Thus it cannot be regarded as a general approach to sensitizing melanoma cells to drug-induced apoptosis.
Accurately interpreting clickthrough data as implicit feedback (2005)

This paper examines the reliability of implicit feedback generated from clickthrough data in WWW search. Analyzing the users' decision process using eyetracking and comparing implicit feedback against manual relevance judgments, we conclude that clicks are informative but biased. While this makes the interpretation of clicks as absolute relevance judgments difficult, we show that relative preferences derived from clicks are reasonably accurate on average.
The Rpd3-Sin3 Histone Deacetylase Regulates Replication Timing and Enables Intra-S Origin Control in <i>Saccharomyces cerevisiae</i> (2004)

The replication of eukaryotic genomes follows a temporally staged program, in which late origin firing often occurs within domains of altered chromatin structure(s) and silenced genes. Histone deacetylation functions in gene silencing in some late-replicating regions, prompting an investigation of the role of histone deacetylation in replication timing control in Saccharomyces cerevisiae. Deletion of the histone deacetylase Rpd3 or its interacting partner Sin3 caused early activation of late origins at internal chromosomal loci but did not alter the initiation timing of early origins or a late-firing, telomere-proximal origin. By delaying initiation relative to the earliest origins, Rpd3 enables regulation of late origins by the intra-S replication checkpoint. RPD3 deletion suppresses the slow S phase of clb5Delta cells by enabling late origins to fire earlier, suggesting that Rpd3 modulates the initiation timing of many origins throughout the genome. Examination of factors such as Ume6 that function together with Rpd3 in transcriptional repression indicates that Rpd3 regulates origin initiation timing independently of its role in transcriptional repression. This supports growing evidence that for much of the S. cerevisiae genome transcription and replication timing are not linked.
A Survey of System Platforms for Mobile Payment (2010)

With the evolution and significant growth in wireless technology and the development of mobile commerce, businesses can achieve superior performance through the implementation of platforms for mobile payment. However, there are several platforms for mobile payment to choose from which makes the selection of an appropriate platform for specific applications a challenging task. In response to this challenge, the most common mobile payment platforms recorded in the literature have been reviewed. This paper presents the result of this review describing the advantages and disadvantages of each system and offers ranking of the technologies considered. MCDM method is used for assessing and comparing different platforms from technical and business points of view. The results indicate that SIM-based application with binary SMS offers the best solution compared to other alternatives.
Combined Abl Inhibitor Therapy for Minimizing Drug Resistance in Chronic Myeloid Leukemia: Src/Abl Inhibitors Are Compatible with Imatinib (2005)

Our results indicate that Src/Abl inhibitors are compatible with imatinib and suggest that combined Abl inhibitor therapy is a feasible treatment strategy for patients with CML.
Development of gonadotrope desensitization to gonadotropin-releasing hormone (GnRH) and recovery are not coupled to inositol phosphate production or GnRH receptor number (1992)

After initial GnRH pretreatment (10 nM, 5 h), subsequent GnRH-stimulated LH release from the gonadotrope was diminished (1 microM GnRH stimulated release of 36.4 +/- 1.4% total cellular LH over 3 h in cells initially pretreated with medium alone compared to 27.4 +/- 1.2% in GnRH-pretreated cells); however, inositol phosphate (IP) production in response to the releasing hormone remained unaffected (1 microM GnRH provoked IP accumulation of 161 +/- 9% above basal levels after 45 min in control cells and 162 +/- 11% in GnRH-pretreated cells). Pretreatment of pituitary cell cultures with NaF (a guanyl nucleotide binding protein activator, 10 mM, 3 h) also decreased subsequent GnRH-stimulated LH release, and in addition, provoked a decrease in GnRH receptor number, an increase in GnRH receptor affinity, reduction of GnRH-stimulated IP production to basal levels, and an increase in the amount of LH released in response to stimulation with the calcium ionophore A23187. In order to determine if the changes in LH release were a result of decreased IP production and/or decreased GnRH receptor binding, the time course of recovery to control levels of these processes was assessed. GnRH receptor binding continued to decrease after NaF pretreatment, reaching a nadir (62% of control) at 6 h after the pretreatment period and recovering at 48 h (90% of control). In contrast, GnRH-provoked IP accumulation did not return to control levels even after 48 h of recovery after NaF pretreatment (1 microM GnRH-stimulated IP accumulation in NaF-pretreated cells was 57% compared to control cells after 48 h of recovery). GnRH-stimulated LH release was inhibited immediately after NaF pretreatment (1 microM GnRH-stimulated LH release in NaF-pretreated cells was 65% of control levels). Cells began to recover within 3 h (80% of control) and were almost completely recovered by 6 h (90% of control). A23187-provoked LH release was enhanced immediately after NaF pretreatment (30 microM A23187-stimulated LH release in NaF-pretreated cells was 170% of control levels). Responsiveness to ionophore was 133% of control by 0.5 h, and complete recovery was measured within 1 h (100% of control). Furthermore, both NaF and GnRH pretreatment still provoked a decrease in gonadotrope responsiveness when IP production was inhibited by the phospholipase C inhibitor U-73122. The results suggest that the development of gonadotrope desensitization (by either NaF or GnRH pretreatment) can be uncoupled from changes in IP production.
Video Information Monitor System Based on FPGA (2012)

In order to realize high speed and real-time video monitoring, a hardware development platform based on FPGA was designed. Utilizing CMOS image sensor OV7620 to collect video information, the data was real-time processed and stored by EP1C12Q24C8 of Cyclone series. A 400×240 resolution LCD display the result. This paper settled the SCCB communication and implemented the software driver for OV7620 and LCD. Two FIFO ping-pong operation were used as data buffer for clock domain conversion to solve the inconsistencies rates problem when various components read and wrote data. The size of video display area can be changed by control signal which greatly improves the performance of the system for accuracy, real-time and high-speed. The experiment results show that the system can clearly display the video surveillance information and is suitable for industrial video information surveillance areas that have rigorous demanding for real-time, power and volume.
Small Business and Its Rivals (1991)

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Growth of icosahedral boron-rich clusters at high pressure (1998)

The stoichiometry of boron suboxide (B6O1-X) synthesized at high pressure lies closer to the nominal composition (x = 0) than materials obtained at atmospheric pressure. The crystallinity of materials obtained in the presence of molten B2O3 is also higher than for sintered powders. Further, for syntheses at 1700-1800 °C between 4 and approximately 5-6 GPa, the well-crystallized particles are dominated by large (up to approximately 40 μm in diameter) icosahedral multiply-twinned particles. This unusual morphology is obtained by Mackay packing; i.e., by assembly of successive shells of icosahedral B12 units around a central icosahedral nucleus. The result is a multiply-twinned particle in which each of the 20 elements has the R3̄m space group of the α-B structure.
Optimized feature exploitation for 3D object recognition using ART neural networks (2002)

In this paper, a study is presented of how self-organizing ART networks can be used to create a trainable, feature-based real-time 3-D object recognition system. Feature extraction is a well known approach to reduce the number of appearances of a three-dimensional object. Since features are derived from only a small part of the information comprised in the original image, it cannot be assumed that a given set of objects is separable in the reduced feature space. To avoid ambiguities, in general, multiple features have to be integrated in an object recognition system. Since feature extraction can be computationally intensive, a real-time system should evaluate features sequentially and terminate recognition when ambiguities are resolved. This paper gives an analysis of the clustering properties of ART 2A-E networks. It is shown how ART networks can be used to generate meaningful hints concerning the object's identity from ambiguous features by exploiting them up to an optimal degree.
Basicity and bulkiness effects of 1,8-diaminonaphthalene, 8-aminoquinoline and their alkylated derivatives on the different efficiencies of η5-C5H5 and η5-C5Me5 ruthenium precatalysts in allylic etherification reactions (2010)

The different behaviours of Ru(η5-C5H5) and Ru(η5-C5Me5) precatalysts, [Ru(η5-C5R5)(NCMe)(N,N)]PF6 (R = H, Me), in the allylic etherification reaction of cinnamyl chloride using the phenoxide anion as a nucleophile was considered. The N,N ligands are the commercial products 1,8-diaminonaphthalene and 8-aminoquinoline, and their derivatives obtained by alkylation of the amino nitrogen atoms: alkyl substituents that are also bulky chiral C2-symmetric frameworks allow modulation of the basicity and steric demand of the ligands. Some of the precatalysts, [Ru(η5-C5R5)(NCMe)(N,N)]PF6 (R = H, Me), were also synthesized and characterized. The cinnamyl phenyl ether isomers were obtained with very high B/L regioselectivity values, either with Ru(η5-C5H5) or Ru(η5-C5Me5) precatalysts. The highest B/L regioselectivity values achieved with Ru(η5-C5Me5) precatalysts were found with the N,N ligand 1,8-diaminonaphthalene and its derivatives; with Ru(η5-C5H5) precatalysts best B/L values were obtained with ligands derived from 8-aminoquinoline. A correlation between the B/L regioselectivity, and the σ-donor power and bulkiness of the substituents at the nitrogen atoms of the N,N coordinated ligand was established, but the Ru(η5-C5H5) or Ru(η5-C5Me5) precatalysts followed an opposite trend. It was also found that the low ee values did not depend on the diastereomeric composition of the chiral-at-metal precatalyst [Ru(η5-C5R5)(NCMe)(N,N)]PF6.
Treatment options for severe sepsis and septic shock (2006)

Despite significant advances in the understanding of the pathophysiology of sepsis, severe sepsis and septic shock continue to be associated with high morbidity and mortality. Eradication of infection, with appropriate antibiotics and source control, remains the cornerstone of sepsis management, but does not ensure survival. Aggressive supportive care, such as fluid resuscitation, vasoactive agents or mechanical ventilation, is often required. With the exception of drotrecogin alfa, attempts to modulate the inflammatory response in sepsis have generally been unsuccessful. Early goal-directed therapy targeting adequate central venous oxygen saturation appears to improve outcome. Recently, there has been renewed interest in the use of corticosteroids, not as anti-inflammatory agents, but as replacement therapy. There is also some evidence to suggest that tight glucose control may improve outcome in these patients.
A new isostatic residual gravity map of the conterminous United States (1985)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1985A new isostatic residual gravity map of the conterminous United StatesAuthors: R. W. SimpsonR. C. JachensR. W. SaltusR. J. BlakelyR. W. SimpsonU.S. Geological Survey, R. C. JachensU.S. Geological Survey, R. W. SaltusU.S. Geological Survey, and R. J. BlakelyU.S. Geological Surveyhttps://doi.org/10.1190/1.1892727 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail FiguresReferencesRelatedDetailsCited ByImaging crustal features and Moho depths through enhancements and inversion of gravity data from the Philippine island arc system7 March 2022 | Progress in Earth and Planetary Science, Vol. 9, No. 1Missing link between the Hayward and Rodgers Creek faultsScience Advances, Vol. 2, No. 10Subsurface geometry of the San Andreas-Calaveras fault junction: Influence of serpentinite and the Coast Range Ophiolite27 October 2014 | Tectonics, Vol. 33, No. 10Late Neogene relative motions of the Pacific and North America Plates26 July 2010 | Tectonics, Vol. 10, No. 1Gravity model studies of Newberry Volcano, Oregon20 September 2012 | Journal of Geophysical Research: Solid Earth, Vol. 93, No. B9 SEG Technical Program Expanded Abstracts 1985ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1985 Pages: 643 publication data© 1985 Copyright © 1985 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 07 Mar 2005 CITATION INFORMATION R. W. Simpson, R. C. Jachens, R. W. Saltus, and R. J. Blakely, (1985), "A new isostatic residual gravity map of the conterminous United States," SEG Technical Program Expanded Abstracts : 197-198. https://doi.org/10.1190/1.1892727 Plain-Language Summary PDF DownloadLoading ...
Direct Transthoracic Access to the Left Ventricle for Catheter Ablation of Ventricular Tachycardia (2010)

Direct percutaneous left ventricular puncture is a viable option for mapping and ablation of left ventricular VT. A minithoracotomy allows better hemostatic control. This technique has a role when other percutaneous approaches are contraindicated.
Single-strand-DNA-binding factors specifically recognize the pyrimidine element in the chick α2(I) collagen gene promoter (1996)

A pyrimidine element with mirror repeats centered at position -192 bp of the chick alpha2(I) collagen promoter interacts with sequence-specific DNA-binding factors. These factors bind to only the pyrimidine strand of this region and have no affinity for the complementary purine strand. Binding activity is also seen with the double-stranded form of this element, but with less affinity than to the single-stranded pyrimidine species. Southwestern blot analyses have shown that proteins of 80 and 134 kDa in chick embryo fibroblast nuclear-extracts bind to the pyrimidine strand, whereas only a 134 kDa DNA-binding protein was found in chondrocyte nuclear extracts. The binding mechanism of these nuclear proteins with single-stranded DNA might be based on a non-B-DNA conformation of the pyrimidine element. The position of this binding site in the promoter region, its potential for adopting an unusual secondary structure and the presence of the 80 kDa binding factor in chick embryo fibroblasts, but not in chondrocytes, suggest a possible role for this factor in the expression of the alpha2(I) collagen gene.
Timely Classification and Verification of Network Traffic Using Gaussian Mixture Models (2020)

We present a novel approach for timely classification and verification of network traffic using Gaussian Mixture Models (GMMs). We generate a separate GMM for each class of applications using component-wise expectation-maximization (CEM) to match the network traffic distribution generated by these applications. We apply our models for both traffic classification, where the goal is to identify the source application from which the traffic originates, by evaluating the maximum posterior probability, and for traffic verification, where the goal is to verify whether the application that claims to be the source of the traffic is as expected, by likelihood testing. Our models use only the first initial packets of truncated flows in order to provide more efficient and timely traffic classification and verification. This allows for triggering timely countermeasures before the end of flows. We demonstrate the effectiveness of our approach by experiments on a public dataset collected from a real network. Our traffic classification approach outperforms other state-of-the-art approaches that are based on machine learning, and achieves up to 97.7% flow classification accuracy when using only 9 first initial packets of flows. We show that 96.6% flow classification accuracy can still be obtained when training the GMMs using only 0.5% of all flows. Our traffic verification approach achieves a minimum Half Total Error Rate (HTER) of 7.65% when using only 6 first initial packets of flows.
Leonard and Swap on 'Deep Smarts' (2005)

An interview with Dorothy Leonard and Walter Swap: The first issue that any organization has to face is the identification of the deep smarts. Dorothy Leonard and Walter Swap are co-authors of the new book 'Deep Smarts: How to Cultivate and Transfer Enduring Business Wisdom.' Leonard is a professor emerita at the Harvard Business School and Swap is a professor of psychology emeritus at Tufts, where he was also dean of the college.
Synthesis and Transfection Properties of a Series of Lipidic Neamine Derivatives (2009)

With the view to develop novel bioinspired nonviral vectors for gene delivery, we synthesized a series of cationic lipids with a neamine headgroup, which incorporates rings I and II of the natural antibiotic aminoglycoside neomycin B. Indeed, we reasoned that neamine might constitute a straightforward and versatile building block for synthesizing a variety of lipophilic aminoglycosides and modulating their characteristics such as size, topology, lipophilicity, number of charges, and charge density. Neamine derivatives bearing long dialkyl chains, one or two neamine headgroups, and four to ten protonatable amine functions were prepared through the selective alkylation of the 4'- or 5-hydroxyl function in ring I and ring II of neamine, respectively. The transfection activity of the twelve derivatives synthesized was investigated in vitro in gene transfection experiments using several mammalian cell lines. The results allowed us to unveil interesting structure-activity relationships and to identify a formulation incorporating a small neamine derivative as a highly efficient gene delivery system.
Caveolin-1 peptide exerts cardioprotective effects in myocardial ischemia-reperfusion via nitric oxide mechanism (2001)

Caveolin-1 is a protein constituent of cell membranes. The caveolin-1 scaffolding region (residues 82-101) is a known inhibitor of protein kinase C. Inhibition of protein kinase C results in maintained nitric oxide (NO) release from the endothelium, which attenuates cardiac dysfunction after ischemia-reperfusion (I/R). Therefore, we hypothesized that the caveolin-1 scaffolding region of the molecule, termed caveolin-1 peptide, might attenuate postischemia polymorphonuclear neutrophil (PMN)-induced cardiac dysfunction. We examined the effects of caveolin-1 peptide in isolated ischemic (20 min) and reperfused (45 min) rat hearts reperfused with PMNs. Caveolin-1 peptide (165 or 330 microg) given intravenously 1 h before I/R significantly attenuated postischemic PMN-induced cardiac dysfunction, as exemplified by left ventricular developed pressure (LVDP) (P < 0.01) and the maximal rate of developed pressure (+dP/dt(max)) (P < 0.01), compared with I/R hearts obtained from rats given 0.9% NaCl. In addition, caveolin-1 peptide significantly reduced cardiac PMN infiltration from 195 +/- 5 PMNs/mm2 in untreated hearts to 103 +/- 5 and 60 +/- 5 PMNs/mm2 in hearts from 165 and 330 microg caveolin-1 peptide-treated rats, respectively (P < 0.01). PMN adherence to the rat coronary vasculature was also significantly reduced in rats given either 165 or 330 microg caveolin-1 peptide compared with rats given 0.9% NaCl (P < 0.01). Moreover, caveolin-1 peptide-treated rat aortas exhibited a 2.2-fold greater basal release of NO than vehicle-treated aortas (P < 0.01), and this was inhibited by NG-nitro-L-arginine methyl ester. These results provide evidence that caveolin-1 peptide significantly attenuated PMN-induced post-I/R cardiac contractile dysfunction in the isolated perfused rat heart, probably via enhanced release of endothelium-derived NO.
Bone turnover and nutritional status in Crohn's disease: relationship to circulating mononuclear cell function and response to fish oil and antioxidants (2005)

Crohn's disease is associated with osteoporosis, malnutrition and altered function of peripheral blood mononuclear cells (PBMC). The responses of circulating immune cells and extra-intestinal manifestations to increased inflammatory activity and to modulation by dietary supplementation are uncertain. The relationships between disease status, bone turnover and body mass and composition, PBMC function and fatty acid availability have been investigated in patients with Crohn's disease. The availability of n-3 and n-6 PUFA is altered in adult patients and interferon (IFN)-gamma production by PBMC is lower. Increased inflammatory activity is associated with increased bone resorption in adult patients and decreased body mass in paediatric patients. In healthy male subjects there is a proportionate relationship between supplementary intake of EPA and DHA (0.3-2.0 g as fish oil/d) in combination with antioxidants (vitamins A, C and E and Se) and incorporation into plasma phospholipids and PBMC, and a non-linear relationship with PBMC synthesis of TNF-alpha, IL-6 and prostaglandin E2 (decrease) and IFN-gamma (increase). In adults with Crohn's disease high-dose fish oil (2.7 g EPA+DHA/d) in combination with antioxidants (vitamins A, C and E and Se) increases the EPA and DHA content of PBMC and decreases the production of IFN-gamma by PBMC, but is not associated with effects on bone turnover or nutritional status.