gebhart/patrepeval huggingface dataset:
Hypotensive Agents. Pyridinecarboxamides and Piperidinecarboxamides<sup>1</sup> (1959)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHypotensive Agents. Pyridinecarboxamides and Piperidinecarboxamides1Joseph Sam, William F. Minor, and Yvon G. PerronCite this: J. Am. Chem. Soc. 1959, 81, 3, 710–713Publication Date (Print):February 1, 1959Publication History Published online1 May 2002Published inissue 1 February 1959https://pubs.acs.org/doi/10.1021/ja01512a051https://doi.org/10.1021/ja01512a051research-articleACS PublicationsRequest reuse permissionsArticle Views202Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Blood Glutamate Scavenging as a Novel Neuroprotective Treatment for Paraoxon Intoxication (2013)

Organophosphate-induced brain damage is an irreversible neuronal injury, likely because there is no pharmacological treatment to prevent or block secondary damage processes. The presence of free glutamate (Glu) in the brain has a substantial role in the propagation and maintenance of organophosphate-induced seizures, thus contributing to the secondary brain damage. This report describes for the first time the ability of blood glutamate scavengers (BGS) oxaloacetic acid in combination with glutamate oxaloacetate transaminase to reduce the neuronal damage in an animal model of paraoxon (PO) intoxication. Our method causes a rapid decrease of blood Glu levels and creates a gradient that leads to the efflux of the excess brain Glu into the blood, thus reducing neurotoxicity. We demonstrated that BGS treatment significantly prevented the peripheral benzodiazepine receptor (PBR) density elevation, after PO exposure. Furthermore, we showed that BGS was able to rescue neurons in the piriform cortex of the treated rats. In conclusion, these results suggest that treatment with BGS has a neuroprotective effect in the PO intoxication. This is the first time that this approach is used in PO intoxication and it may be of high clinical significance for the future treatment of the secondary neurologic damage post organophosphates exposure.
Annotations for HTML to VoiceXML Transcoding: Producing Voice WebPages with Usability in Mind (2002)

Web pages contain a large variety of information, but are largely designed for use by graphical web browsers. Mobile access to web-based information often requires presenting HTML web pages using channels that are limited in their graphical capabilities such as small-screens or audio-only interfaces. Content transcoding and annotations have been explored as methods for intelligently presenting HTML documents. Much of this work has focused on transcoding for small-screen devices such as are found on PDAs and cell phones. Here, we focus on the use of annotations and transcoding for presenting HTML content through a voice user interface instantiated in VoiceXML. This transcoded voice interface is designed with an assumption that it will not be used for extended web browsing by voice, but rather to quickly gain directed access to information on web pages. We have found repeated structures that are common in the presentation of data on web pages that are well suited for voice presentation and navigation. In this paper, we describe these structures and their use in an annotation system we have implemented that produces a VoiceXML interface to information originally embedded in HTML documents. We describe the transcoding process used to translate HTML into VoiceXML, including transcoding features we have designed to lead to highly usable VoiceXML code.
Hyperoxic Suppression of FC-γ Receptor-Mediated Phagocytosis by Isolated Murine Pulmonary Macrophages (1995)

Lower respiratory tract exposure to high oxygen (O2) concentrations is known to induce changes in pulmonary function through effects on several cell types located within the lung parenchyma, including pulmonary macrophages (PM). We studied the effects of hyperoxic exposure on phagocytosis via Fc-gamma receptors (FcR) on isolated murine PM. PM cultured in hyperoxic conditions exhibited little change in ingestion via FcR for up to 96 h, compared with significant increases in ingestion by PM cultured in 21% O2 over the same time period. This suppression was reversible and occurred whether 50 or 100% O2 concentrations were used for hyperoxic exposure. Addition of the potent macrophage-activating agent interferon-gamma (IFN-gamma) to cultured PM further increased FcR-mediated phagocytosis in normoxic PM but had no effect on PM cultured in 100% O2. Analysis of FcR expression by flow cytometry using monoclonal antibodies specific for two different FcR classes revealed that culture in normoxic conditions increased surface expression of both FcR classes. Hyperoxic culture inhibited up-regulation of the high-affinity FcR but did not affect low-affinity FcR up-regulation, suggesting that hyperoxic effects were not due solely to effects on regulation of FcR expression. However, hyperoxic exposure completely suppressed FcR-mediated actin polymerization. These findings suggest that hyperoxic exposure impairs PM ability to increase FcR-mediated phagocytic activity after appropriate stimulation, which could impair the lung's defenses against infection.
MAGIC: An Automated N-Linked Glycoprotein Identification Tool Using a Y1-Ion Pattern Matching Algorithm and <i>in Silico</i> MS<sup>2</sup> Approach (2015)

Glycosylation is a highly complex modification influencing the functions and activities of proteins. Interpretation of intact glycopeptide spectra is crucial but challenging. In this paper, we present a mass spectrometry-based automated glycopeptide identification platform (MAGIC) to identify peptide sequences and glycan compositions directly from intact N-linked glycopeptide collision-induced-dissociation spectra. The identification of the Y1 (peptideY0 + GlcNAc) ion is critical for the correct analysis of unknown glycoproteins, especially without prior knowledge of the proteins and glycans present in the sample. To ensure accurate Y1-ion assignment, we propose a novel algorithm called Trident that detects a triplet pattern corresponding to [Y0, Y1, Y2] or [Y0-NH3, Y0, Y1] from the fragmentation of the common trimannosyl core of N-linked glycopeptides. To facilitate the subsequent peptide sequence identification by common database search engines, MAGIC generates in silico spectra by overwriting the original precursor with the naked peptide m/z and removing all of the glycan-related ions. Finally, MAGIC computes the glycan compositions and ranks them. For the model glycoprotein horseradish peroxidase (HRP) and a 5-glycoprotein mixture, a 2- to 31-fold increase in the relative intensities of the peptide fragments was achieved, which led to the identification of 7 tryptic glycopeptides from HRP and 16 glycopeptides from the mixture via Mascot. In the HeLa cell proteome data set, MAGIC processed over a thousand MS(2) spectra in 3 min on a PC and reported 36 glycopeptides from 26 glycoproteins. Finally, a remarkable false discovery rate of 0 was achieved on the N-glycosylation-free Escherichia coli data set. MAGIC is available at http://ms.iis.sinica.edu.tw/COmics/Software_MAGIC.html .
Multistep Redoxsystems, LX. 1,4,5,8‐Tetraoxo‐1,4,5,8‐tetrahydrothianthrene: Synthesis, Structure, and Spectroelectrochemical Properties (1993)

Abstract The synthesis, structure, cyclovoltammetric and spectroelectrochemical data of 1,4,5,8‐tetraoxo‐1,4,5,8‐tetrahydrothianthrene ( 2a ) are presented. A relation between the positive partial charge at the sulfur atom and the dihedral angle at the SS axis is discussed on the basis of semiempirical MO calculations.
Optically Excited Micromechanical Resonator Pressure Sensor (1988)

There has been considerable interest shown in a new class of optical sensors based on the phenomenon whereby light from an intensity modulated optical source induce transverse vibrations of a micromechanical resonator on which it is incident (1). Such micromechanical resonators have most commonly been fabricated in single crystal silicon using processing steps which include photolithography, impurity diffusion and anisotropic chemical etching (2).
Noise‐resolution tradeoffs in x‐ray CT imaging: A comparison of penalized alternating minimization and filtered backprojection algorithms (2011)

The results of this simulation study imply that penalized AM has the potential to reconstruct images with similar noise and resolution using a fraction (10%-70%) of the FBP dose. However, this dose-reduction potential depends strongly on the AM penalty parameter and the contrast magnitude of the structures of interest. In addition, the authors' results imply that the advantage of AM can be maximized by optimizing the nonquadratic penalty function to the specific imaging task of interest. Future work will extend the methods used here to quantify noise and resolution in images reconstructed from real CT data.
Simulations of Thermal Upgrading Methods for Oil Shale Reservoirs (2012)

Abstract This paper analyzes reaction and thermal front development in porous reservoirs with reacting flows, such as those encountered in shale oil extraction. A set of dimensionless parameters and a 3D code are developed in order to investigate the important physical and chemical variables of such reservoirs when heated by in situ methods. This contribution builds on a 1D model developed for the precursor study to this work. Theory necessary for this study is presented, namely shale decomposition chemical mechanisms, governing equations for multiphase flow in porous media and necessary closure models. Plotting the ratio of the thermal wave speed to the fluid speed allows one to infer that the reaction wave front ends where this ratio is at a minimum. The reaction front follows the thermal front closely, thus allowing assumptions to be made about the extent of decomposition solely by looking at thermal wave progression. Furthermore, this sensitivity analysis showed that a certain minimum permeability is required in order to ensure the formation of a traveling thermal wave. It was found that by studying the non-dimensional governing parameters of the system one can ascribe characteristic values for these parameters for given initial and boundary conditions. This allows one to roughly predict the performance of a particular method on a particular reservoir given approximate values for initial and boundary conditions. Channelling and flow blockage due to carbon residue buildup impeded each method’s performance. Blockage was found to be a result of imbalanced heating.
A New Method to Extract Piezoresistive Coefficients in Polysilicon Through Gauges Placed on a MEMS Membrane (2012)

This paper presents a new method to evaluate piezoresistive coefficients of polysilicon in the case of N-doping but valid for other types. We measured and simulated the mechanical stress profile distribution along a bossed membrane using several gauges placed along the radial axis of round membranes. Pressure was applied to the membrane. The electromechanical characterizations of the MEMS membrane are in accordance with the simulations and allowed to extract piezoresistive coefficients of the heavily doped polysilicon.
Separating signal and noise in vibrotactile devices for the deaf (1990)

This paper briefly reviews a series of experiments demonstrating that a sound-to-touch transform of signal and noise may be perceptually separated by providing tactile cues for sound localization. Following this, three experiments are reported in which it is shown that such stereotactile cues are available if two vibrotactile devices (Minifonators, produced by Siemens Co. Ltd.), are used instead of one. With this system, subjects were able to attend to a target signal (male voice) in white noise and when a female voice was presented simultaneously. This ability depended upon a sufficient spatial separation of the target and noise in acoustic space. These findings appear to have applications in the design of tactile hearing aids and cochlear implants when used in noisy environments or when more than one sound is present.
Properties of random and block copolymers of butadiene and styrene. I. Dynamic properties and glassy transition temperatures (1967)

Abstract The effect of monomer sequence on physical properties was investigated for butadienestyrene solution copolymers made by organolithium initiation. The polymers varied from random copolymers of uniform composition along the polymer chain to ideal block polymers of specific block sequence arrangement and included rubbers of intermediate degrees of randomness. Uniform composition random copolymers exhibit a single glass transition temperature and a very narrow dynamic loss peak corresponding to this transition. The glass transition can be predicted from the styrene content and the microstructure of the butadiene portion of the rubber. Random copolymers in which composition varies along the polymer chain, and to some extent between molecules, exhibit a single glass transition, but the dynamic loss peak is broadened. The extent of this broadening is shown to be compatible with the sequence distribution, polymer segments of various compositions losing mobility at different temperatures. This indicates a tendency for association between segments of different temperatures. This indicates a tendency for association between segments of different chains which are similar in composition. Block copolymers display two transitions, corresponding to T g for each type of block. The position and width of the dynamic loss peaks are related to block length and compositional purity of the blocks.
Added Value of SPECT/CT for Correlation of MIBG Scintigraphy and Diagnostic CT in Neuroblastoma and Pheochromocytoma (2008)

In cases of equivocal diagnostic CT, SPECT/CT bridges the gap between MIBG scintigraphy and diagnostic CT, with guidance of the diagnostic CT and characterization of its findings. In this small series, MIBG SPECT/CT increased the diagnostic certainty in 89% of discordant studies.
Transitional arrangements for PNs to achieve a community nurse specialist qualification (1995)

At the Edinburgh Practice Nurse Conference, Pippa Gough outlined that the UKCC has agreed that, during the three year transitional period, practice nurses may:
Marketing of information in the water sector in Tanzania: a strategy for MAJIDOC (1992)

Outlines a strategy for marketing the information products and services of the Water and Sanitation Information and Documentation Centre (MAJIDOC) of the Water Resources Institute in Dar es Salaam, Tanzania. Discusses the market environment, resource requirements and objectives of the marketing strategy, and outlines an action programme involving internal and external promotion through various types of media and activities. Includes a budget plan for financing the implementation of the strategy.
Two modified selenite media for the recovery of Yersinia enterocolitica from meats (1980)

Yersinia enterocolitica is one of the few human pathogens that grows at the proper food refrigeration temperatures of 0 to 5 degrees C. Although the isolation of environmental biotypes of Y. enterocolitica from many types of food and water has been reported in the literature, the recovery of the sensitive strains inoculated into foods has been slow and uncertain. Rapid recovery of several clinical strains inoculated into meats was accomplished by using two modified selenite broths without added nutrients. It was critical to restrict the sample size of the blended meat suspension at the 0.2-g/100 ml level, thereby restricting the growth of the total bacterial population in the selenite enrichment media. Otherwise, the slower growing Y. enterocolitica would be overwhelmed by the faster growing normal bacterial flora from the meat. Both the resistant serotype O:3 and the sensitive O:8 clinical isolates of Y. enterocolitica were recovered from the modified selenite enrichment media after 2 and 3 days of incubation at 22 degrees C.
Arousing feedback rectifies lapse in performance and corresponding EEG power spectrum (2010)

This study explores electroencephalographic (EEG) dynamics and behavioral changes in response to arousing auditory signals presented to individuals experiencing momentary cognitive lapses. Arousing auditory feedback was delivered to the subjects in half of the non-responded lane-deviation events during a sustained-attention driving task, which immediately agitated subject's responses to the events. The improved behavioral performance was accompanied by concurrent power suppression in the theta- and alpha-bands in the lateral occipital cortices. This study further explores the feasibility of estimating the efficacy of arousing feedback presented to the drowsy subjects by monitoring the changes in EEG power spectra.
Surface properties of RGD-peptide grafted polyurethane block copolymers: Variable take-off angle and cold-stage ESCA studies (1993)

Variable take-off angle and cold-stage ESCA measurements were utilized to analyze the surface composition of five polyurethane block copolymers. The polymers studied included a PTMO-polyurethane control, a carboxylated version of the control polyurethane, and three different peptide grafted (GRGESY, GRGDSY, and GRGDVY) polyurethanes. On dry samples the nitrogen signal detected using ESCA decreased with increasing take-off angle (i.e. as the specimen was probed closer to the surface) for all five polymers. This was believed to be due to the depletion of nitrogen-containing urethane hard segments at the surface. For all five polymers, the surface nitrogen concentration, associated with the hard segment, increased upon hydration. A greater increase of nitrogen concentration was observed for the peptide grafted polymers which suggests that grafting of the hydrophilic peptides to the polyurethane augments the hard segment enrichment at the surface upon hydration. Upon dehydration, the nitrogen concentration decreased for all five polymers suggesting migration of the more hydrophobic PTMO soft segment to the surface. In vitro endothelial cell adhesion showed an increase of cell attachment on prehydrated RGD-containing peptide grafted polyurethanes, but not on the other polymers. This result suggests an enhancement of peptide density at the aqueous interface, in good agreement with the ESCA studies.
Determination of the gate-tunable band gap and tight-binding parameters in bilayer graphene using infrared spectroscopy (2009)

We present a compelling evidence for the opening of a bandgap in exfoliated bottom-gated bilayer graphene by fitting the gate-voltage-modulated infrared reflectivity spectra in a large range of doping levels with a tight-binding model and the Kubo formula. A close quantitative agreement between the experimental and calculated spectra is achieved, allowing us to determine self-consistently the full set of Slonczewski-Weiss-McClure tight-binding parameters together with the gate-voltage-dependent bandgap. The doping dependence of the bandgap shows a good agreement with the existing calculations that take the effects of self-screening into account. We also identify certain mismatches between the tight-binding model and the data, which can be related to electron-electron and electron-phonon interactions.
Cryosurgery for the treatment of chronic rhinitis (1973)

Abstract In 1970, cryosurgery was reported as effective treatment for chronic rhinitis. 1 Since that time, several hundred patients have been treated with better results, almost no complications, and simplification of the techniques. Improved equipment, selection of patients, probe application, replacement of Freon with Nitrous Oxide as the cooling agent, and prevention of complications have been reported. 5 Similar success has been reported by colleagues here and in England. 4 Subjective and objective evaluation after three to four years suggests the superiority of this technique. While relief of obstruction is almost certain, even in the few patients for whom more than one treatment has been necessary, rhinorrhea and sneezing are not always relieved by simply destroying diseased mucosa. More recently, as a result of reports of relief of the latter symptoms by vidian nerve section, 2,3 patients have been treated with a “hooked” nasal probe positioned on branches of the nerves at the spheno‐palatine foramen, either at the time of turbinectomy or later. The latter procedure is not considered to destroy the nerves permanently and is considered a “treatment” because nerves regenerate. At present cryosurgery is frequently used when mucosal disease results in “failure” of nasal septal surgery and as a complement of conventional reconstructive surgery. Relatively inexpensive Nitrous Oxide cryoprobes should make the technique available for most otolaryngologists.
Charge selection algorithms for maximizing sensor network life with UAV-based limited wireless recharging (2013)

Monitoring bridges with wireless sensor networks aids in detecting failures early, but faces power challenges in ensuring reasonable network lifetimes. Recharging select nodes with Unmanned Aerial Vehicles (UAVs) provides a solution that currently can recharge a single node. However, questions arise on the effectiveness of a limited recharging system, the appropriate node to recharge, and the best sink selection algorithm for improving network lifetime given a limited recharging system. This paper simulates such a network in order to answer those questions. It explores five different sink positioning algorithms to find which provides the longest network lifetime with the added capability of limited recharging. For a range of network sizes, our results show that network lifetime improves by over 350% when recharging a single node in the network, the best node to recharge is the one with the lowest power level, and that either the Greedy Heuristic or LP sink selection algorithms perform equally well.
Acoustic echo canceller software for voip hands-free application on smartphone and tablet devices (2014)

An acoustic echo cancellation (AEC) method developed for voice over IP (VoIP) hands-free applications is proposed. This method can effectively reduce undesired acoustic echo arriving at a microphone from a loudspeaker and emphasize the target talker's voice when near-end and far-end talkers speak simultaneously (i.e. double-talk), irrespective of smartphone/tablet device models. This method mainly involves cancellation of non-linear acoustic echo caused by loudspeaker distortion, residual echo reduction robust against echo-path change, and estimation of pure delay resulting from both room echo and audio input/output buffers. The experimental results show that the proposed AEC method reduced more than 40 dB of undesired echo for every smartphone or tablet used for the evaluation. This indicates that the performance of the proposed AEC method does not depend on the difference in the acoustic characteristics of individual devices.