gebhart/patrepeval huggingface dataset:
Eleven novel JAK3 mutations in patients with severe combined immunodeficiency?including the first patients with mutations in the kinase domain (2001)

Defects of the JAK3-gene are known to cause an autosomal recessive form of severe combined immunodeficiency with almost absent T-cells and functionally defective B-cells (T-B+SCID). The JAK3 protein, an intracellular tyrosine kinase, is crucial for signal-transmission from the common gamma chain to the Signal Transducers and Activators of Transcription (STATs) that drive gene expression in the nucleus. We present nine novel patients with eleven distinct mutations (g.96A>G, g.268G>C, IVS12-1G>A, g.2046C>T, g.2160C>T, g.2175G>A, g.2187G>T, g.2391C>T, g.2406C>T, IVS18+3G>C) among them a mutation in the kinase domain (JH1: g.3167del). The clinical phenotype of the patients shows an unusually broad spectrum ranging from classical SCID to almost normal. In order to understand the complex genotype-phenotype correlation we studied expression and function (by IL-2 induced phosphorylation) of the newly identified and two other alleles with JH1 mutations we recently reported. We found the first mutation in the JH1-domain of JAK3, that precludes kinase activity (L910S). The two other JH1 mutations both caused a premature stop. One of them (C1024fsX1037) also abolished any phosphorylation of JAK3 and expression of the protein. The other mutation (Y1023X), affecting the last JH1 tyrosine, may allow for residual protein expression and phosphorylation. This may indicate that the part of the kinase region downstream Y1023, is not essential for the function of JAK3.
Optimal active noise control in large rooms using a “locally global” control strategy (2005)

The feasibility of applying active noise control in large rooms, in which global control is very difficult, is investigated. Local control can only ensure sound attenuation near error-sensor positions. Considering that workers usually work only in certain regions of a workroom, a new “locally global” control strategy is proposed. The objective is to reduce the acoustic potential energy in the target region. Compared to local control, “locally global” control ensures overall noise reduction over the target region. Compared to global control, it allows the number of control channels to be significantly reduced. The placements of the control loudspeakers and error microphones must be optimized to ensure that, while the sum of the squared sound pressures at the error sensors is minimized, the potential energy in the target region is reduced. Room sound fields are modeled using the image-source method and point sources. Genetic algorithms are used to optimize the locations of the control loudspeakers and error microphones. Both numerical and experimental results are presented. The sensitivities of control performance to variations in the excitation frequency, the control-source positions, and the error-sensor locations are investigated.
Regulation of proline utilization in enteric bacteria: cloning and characterization of the Klebsiella put control region (1991)

Enteric bacteria can grow on proline as the sole nitrogen and carbon source. Expression of the proline utilization (put) operon in Klebsiella strains and Escherichia coli is responsive to nitrogen regulation. In contrast, Salmonella typhimurium cannot activate put operon expression when growing in medium with glucose as a carbon source and proline as the sole nitrogen source. To compare nitrogen regulatory sites in the control regions of the put operons in these three closely related genera, we cloned the Klebsiella put operon onto a plasmid. The putA and putP genes were localized on the plasmid by transposon mutagenesis. The DNA sequence of the put control region was determined and compared with those of the put control regions from S. typhimurium and E. coli. The overall size and organization of the put control region were very similar in all three bacteria. However, no obvious ntr regulatory sites were found in this region, and transcription of the put genes started at the same sites during growth with limiting or excess nitrogen. These results strongly suggested that the Klebsiella put operon may not be directly regulated by the ntr system.
Learning to Predict High-Quality Edge Maps for Room Layout Estimation (2016)

The goal of room layout estimation is to predict the three-dimensional box that represents the room spatial structure from a monocular image. In this paper, a deconvolution network is trained first to predict the edge map of a room image. Compared to the previous fully convolutional networks, the proposed deconvolution network has a multilayer deconvolution process that can refine the edge map estimate layer by layer. The deconvolution network also has fully connected layers to aggregate the information of every region throughout the entire image. During the layout generation process, an adaptive sampling strategy is introduced based on the obtained high-quality edge maps. Experimental results prove that the learned edge maps are highly reliable and can produce accurate layouts of room images.
Data mining techniques to improve no-show forecasting (2010)

In order to maximum the profit of each flight, the airlines always have some over-booking in one flight. Accurate forecasts of the expected number of noshows for each flight can increase airline revenue by reducing the number of spoiled seats and the number of involuntary denied boarding at the departure gate. In this paper, we develop a combined model to predict no-show rates using historical data and specific information on the individual passengers booked on each flight. Meanwhile, we propose some data mining techniques to improve no-show forecasting. A case study and the relative performance of some methods are introduced, together with some discussion on further research.
Simplifying the Creation of Hollow Metallic Nanostructures: One‐Pot Synthesis of Hollow Palladium/Platinum Single‐Crystalline Nanocubes (2009)

Abstract Einfacher effizient : Eine Synthesestrategie wird vorgestellt, die einkristalline hohle Pd/Pt‐Nanowürfel liefert (rechts im Bild; links: Pd‐Nanowürfel). Verglichen mit ähnlich großen kompakten Pd/Pt‐Nanowürfeln haben die hohlen Pd/Pt‐Nanowürfel eine größere zugängliche Oberfläche und damit eine höhere Aktivität bei der elektrokatalytischen Ameisensäureoxidation. magnified image
Posterior plates in the management of cervical instability: long-term results in 44 patients (1994)

Although posterior plates are increasingly used to manage cervical spinal instability, long-term follow-up evaluation of patients with a critical analysis of efficacy and complications has not been reported. The authors have retrospectively analyzed the outcome in 44 consecutive patients (37 males and seven females, age range 16 to 80 years) treated with posterior cervical plates. The indications for instrumentation were instability due to trauma in 42 cases, tumor in one, and infection in one. In four patients the follow-up period was limited to 3, 5, 11, and 16 months. Two patients died of chronic medical problems 4 and 9 months after treatment. The remaining 38 patients were followed from 2 to 6 years (mean 46 months). One motion segment was stabilized in 23 patients using two-hole plates; two motion segments were stabilized in the other 21 patients using three-hole plates. In the majority of patients (37 cases), supplemental bone grafting was not used. Patients were immobilized postoperatively in a Philadelphia collar. Solid arthrodesis was achieved in 39 (93%) of 42 patients. Three patients required revision of the cervical plating: in one patient with a C-5 burst fracture, two-hole plates were applied at C5-6 and progressive kyphosis mandated anterior fusion; the second patient required posterior wiring due to screw pull-out resulting from a technical error in screw insertion; the third patient, who refused to wear an orthosis postoperatively, also developed screw pull-out. In two patients who went on to spinal fusion, there was an increase in sagittal kyphosis (6 degrees and 8 degrees) without clinical sequelae. Screw loosening was noted in five patients, involving eight (3.8%) of the 210 lateral mass screws; this complication resulted in instrumentation failure or increased kyphosis in three cases. There were two superficial infections. This analysis indicates that posterior cervical plating is highly effective; at long-term follow-up review the cervical spine was successfully stabilized in 93% of cases. Plate failure was related to faulty screw placement, failure to include sufficient motion segments, and noncompliance with postoperative orthoses. Halo vest immobilization was unnecessary and supplemental bone grafting was generally not required for recent trauma.
An analysis of the nutritive composition in the seed kernel of Litchi chinesis (1998)

In this paper the nutritive composition in the seed kernel of Litchi chinesis was analyzed. The results show that fresh Litchi seed kernel contains starch (40.72%), crude fiber (24.55%), protein (4.93%), Mg(0.28%), Ca(0.21%) and P(0.11%). The largest composition in the seed kernel oil are oleic acid (29%) and Litchi acid (28%), next is linoleic acid (19%). It is suggested that litchi seed kernel may serve as a good source for making health-care food for the middle-aged and the old.
Thermal Excitation and Piezoresistive Detection of Cantilever In-Plane Resonance Modes for Sensing Applications (2010)

Thermally excited and piezoresistively detected bulk-micromachined cantilevers vibrating in their in-plane flexural resonance mode are presented. By shearing the surrounding fluid rather than exerting normal stress on it, the in-plane mode cantilevers exhibit reduced added fluid mass effects and improved quality factors in a fluid environment. In this letter, different cantilever geometries with in-plane resonance frequencies from 50 kHz to 2.2 MHz have been tested, with quality factors as high as 4200 in air and 67 in water.
Advanced studies of selection schemes for dual virtual-metrology outputs (2009)

Advanced studies of selection schemes between neural-network (NN) and multiple-regression (MR) outputs of a virtual metrology system (VMS) are presented in this paper. Both NN and MR are applicable algorithms for implementing VM conjecture models. But a MR algorithm may achieve better accuracy only with a stable process, whereas a NN algorithm may has superior accuracy when equipment property drift or shift occurs. To take advantage of the merits of both MR and NN algorithms, the simple-selection scheme (SS-scheme) was proposed in CASE 2008 to enhance virtual-metrology (VM) conjecture accuracy. This SS-scheme simply selects either NN or MR output. Recently, with advanced studies, a weighted-selection scheme (WS-scheme), which computes the VM output with a weighted sum of NN and MR results, has been developed. Besides the example with the CVD process of fifth generation TFT-LCD used in the CASE 2008 paper, a new example with the photo process is also adopted in this paper to test and compare the conjecture accuracy among solo NN, solo MR, SS-scheme, and WS-scheme. One-hidden-layered back-propagation neural network (BPNN-I) is adopted for establishing the NN conjecture model. Test results show that the conjecture accuracy of the WS-scheme is the best among those of solo NN, solo MR, SS-scheme, and WS-scheme algorithms.
Digestibility of Bovine Milk Whey Protein and β-Lactoglobulin in Vitro and in Vivo (1998)

Bovine milk whey proteins were treated with porcine stomach pepsin, bovine chymosin, human uropepsin, and gastric juice from rat stomach at various pH values. Although α-lactalbumin and bovine serum albumin were hydrolyzed by these proteases, β-lactoglobulin (β-LG) was not hydrolyzed by any pepsin samples at any pH in vitro. Heat-denatured whey proteins, including heated β-LG, were easily hydrolyzed by pepsins. Native β-LG injected into the stomach of a rat was not digested in stomach in vivo, whereas heat-denatured β-LG was digested in the stomach of a rat. Native β-LG as well as the heated sample was hydrolyzed by both commercially available porcine pancreatin and the rat pancreatic juice collected from rat intestine in vitro. Native β-LG injected into the stomach was digested in the intestine in vivo as well as heat-denatured β-LG. The body weights of rats fed heated β-LG increased more rapidly than those of rats fed native β-LG. Keywords: β-Lactoglobulin; milk whey protein; pepsin; pancreatic enzymes; digestibility
The complete mitochondrial genome of the wallaroo ( <i>Macropus robustus</i> ) and the phylogenetic relationship among Monotremata, Marsupialia, and Eutheria (1997)

The complete mitochondrial DNA (mtDNA) (16,896 nt) of the wallaroo (Macropus robustus) was sequenced. The concatenated amino acid sequences of 12 mitochondrial protein-coding genes of the wallaroo plus those of a number of other mammals were included in a phylogenetic study of early mammalian divergences. The analysis joined monotremes and marsupials (the Marsupionta hypothesis) to the exclusion of eutherians. The analysis rejected significantly the commonly acknowledged Theria hypothesis, according to which Marsupialia and Eutheria are grouped together to the exclusion of Monotremata. The region harboring the gene for lysine tRNA (tRNA-Lys) in the mtDNA of other vertebrates is in the wallaroo occupied by a sequence (tRNA-Lys) that lacks both an anticodon loop as well as the anticodon for the amino acid lysine. An alternative tRNA-Lys gene was not identified in any other region of the mtDNA of the wallaroo, suggesting that a tRNA-Lys of nuclear origin is imported into marsupial mitochondria. Previously described RNA editing of tRNA-Asp and rearrangement of some tRNA genes were reconfirmed in the mtDNA of the wallaroo. The divergence between Monotremata/Marsupialia and Eutheria was timed to approximately 130 million years before present (MYBP). The same calculations suggested that Monotremata and Marsupialia diverged approximately 115 MYBP and that Australian and American marsupials separated approximately 75 MYBP. The findings also show that many, probably most, extant eutherian orders had their origin in middle to late Cretaceous times, 115-65 MYBP.
PRMDL: a machine description language for clustered VLIW architectures (2001)

Summary form only given. PRMDL is a format of the central machine description file that contains parameters of the whole retargetable compiler-simulator framework. The format features separate software and hardware views on the processor and defines a wide scope of the framework retargetability, enabling platform-based processor design and vast design space exploration for clustered VLIW architectures.
Experimental Study on the Pyrolysis Characteristics of the Poplar Wood (2014)

The thermal gravimetric analysis of poplar was carried out at heating rates of 20°C/min,40°C/min and 60°C/min with the thermogravimetric analyzer,model Q50.The analysis of TG and DTG curves indicates that the pyrolysis process of the poplar is divided into four stages of drying, pyrolysis preheating, pyrolysis and charring.The thermal hysteresis occurs with the heating rates increasing.
Autofluorescence characteristics of oral mucosa (1997)

This technique accurately differentiates normal from abnormal tissues in vitro and has the potential applications for in vivo use as a noninvasive diagnostic tool.
The effect of cryopreservation on hormone secretion in vitro and morphology of human parathyroid tissue. (1986)

The hormone secretion from human parathyroid tissue autografted after cryopreservation can fail frequently. In this study we examined the effects of the cryopreservation procedure on parathyroid hormone secretion in vitro and the viability of parathyroid cells to identify possible reasons for graft failure. Cryopreservation did not affect quantitative parathyroid hormone release from single-cell suspensions or its calcium-and magnesium-dependent regulatory mechanisms. However, morphometric analysis of thawed 1 mm3 graft particles showed various degrees of necrosis when compared with fresh grafts. Thus partial necrosis of cryopreserved tissue appears to contribute to poor transplantation results compared with immediate replantation of fresh parathyroid tissue. This limitation can be overcome by increasing the number of frozen graft particles used for autotransplantation. The percentage of viable cells should be accounted for by morphometric analysis and this factor used when calculating the number of graft particles employed.
GPS Measurement of Wind-Induced Suspension Bridge Girder Displacements (2000)

A new method using the Global Positioning System (GPS) was proposed to directly measure the suspension bridge girder displacements induced by wind forces. The field measurements were carried out using this system on an existing suspension bridge during the strong wind season. The semistatic displacements of the girders were successfully obtained, and agreed well with the numerically predicted values and the wind tunnel test results. The spectral densities of the displacements measured by GPS corresponded with the numerical results by the finite-element method analysis and the forced vibration test results. The gust response of the girder due to the turbulence of the wind flow was evaluated from the acceleration records measured by accelerometers and compared with the GPS data. The mode frequencies of both results showed good agreement in the low-frequency range and the spectral peaks estimated by the accelerometers corresponded to the GPS values with good accuracy. It is concluded that the GPS method is reliable and useful to clarify the semistatic and gust response behaviors of long-span bridges.
NOISE IN PIANO TONE, A QUALITATIVE ELEMENT (1940)

NOISE IN PIANO TONE, A QUALITATIVE ELEMENT WILLIAM G. HILL WILLIAM G. HILL Search for other works by this author on: Oxford Academic Google Scholar The Musical Quarterly, Volume XXVI, Issue 2, April 1940, Pages 244–259, https://doi.org/10.1093/mq/XXVI.2.244 Published: 01 April 1940
Role of Prolyl Hydroxylation in Oncogenically Stabilized Hypoxia-inducible Factor-1α (2002)

Stabilization of the hypoxia-inducible factor-1 (HIF-1) protein is essential for its role as a regulator of gene expression under low oxygen conditions. Here, employing a novel hydroxylation-specific antibody, we directly show that proline 564 of HIF-1alpha and proline 531 of HIF-2alpha are hydroxylated under normoxia. Importantly, HIF-1alpha Pro-564 and HIF-2alpha Pro-531 hydroxylation is diminished with the treatment of hypoxia, cobalt chloride, desferrioxamine, or dimethyloxalyglycine, regardless of the E3 ubiquitin ligase activity of the von Hippel-Lindau (VHL) tumor suppressor gene. Furthermore, in VHL-deficient cells, HIF-1alpha Pro-564 and HIF-2alpha Pro-531 had detectable amounts of hydroxylation following transition to hypoxia, indicating that the post-translational modification is not reversible. The introduction of v-Src or RasV12 oncogenes resulted in the stabilization of normoxic HIF-1alpha and the loss of hydroxylated Pro-564, demonstrating that oncogene-induced stabilization of HIF-1alpha is signaled through the inhibition of prolyl hydroxylation. Conversely, a constitutively active Akt oncogene stabilized HIF-1alpha under normoxia independently of prolyl hydroxylation, suggesting an alternative mechanism for HIF-1alpha stabilization. Thus, these results indicate distinct pathways for HIF-1alpha stabilization by different oncogenes. More importantly, these findings link oncogenesis with normoxic HIF-1alpha expression through prolyl hydroxylation.
Techniques for developing comprehension in reading (1984)

This paper presents four techniques that are designed to extend readers' responses to literature. The suggestions are based on two philosophical premises.
Spring Quarterly Meeting 1987 (1987)

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Resonant Dc Link In Pwm Ac Chopper (2009)

This paper proposes a resonant dc link in PWM ac chopper. This can solve the spike problems and also reduce the switching loss. The configuration and PWM pattern of the proposed technique are presented. The simulation results are used to confirm the theory.
Image misregistration effects on hyperspectral change detection (2008)

This paper covers the impact of registration errors between two images on chronochrome and covariance equalization predictors used for hyperspectral change detection. Hyperspectral change detection involves the comparison of data collected of the same spatial scene on two different occasions to try to identify anomalous man-made changes. Typical change detection techniques employ a linear prediction method followed by a subtraction step to identify changes. These linear predictors rely upon statistics from both scenes to determine a respective gain and offset. Chronochrome and covariance equalization remain two common predictors used in the change detection process. Chronochrome relies upon a cross-covariance matrix for prediction whereas covariance equalization relies solely upon the individual covariance matrices. In theory, chronochrome seems more susceptible to image misregistration issues as joint statistic estimates may suffer with registration error present. This paper examines the validity of this assumption. Using a push-broom style imaging spectrometer mounted on a pan and tilt, visible to near infrared data of scenes suitable for change detection analysis are gathered. The pan and tilt system ensures initial misregistration of the data is minimal. Using simple translations of the scenes, misregistration impacts upon prediction error and change detection are examined for varying degrees of shift.
Reduced chondrogenic and adipogenic activity of mesenchymal stem cells from patients with advanced osteoarthritis (2002)

These results raise the possibility that the increase in bone density and loss of cartilage that are characteristic of OA may result from changes in the differentiation profile of the progenitor cells that contribute to the homeostatic maintenance of these tissues.
Cervical vertebral fractures in 56 dogs: a retrospective study (1999)

The clinicopathological features of cervical fractures in 56 dogs were reviewed. "Hit by car" (HBC) was the most common inciting cause, and the axis and atlas were the vertebrae most frequently affected. Surgical treatment was associated with high (36%) perioperative mortality. However, all dogs that survived the perioperative period achieved functional recovery. Functional recovery was achieved in 25 (89%) of 28 nonsurgically treated dogs with adequate follow-up. Overall, severity of neurological deficits (nonambulatory status) and prolonged interval (five days or longer) from trauma to referral were associated with poorer outcome. Nonsurgical treatment is a viable therapeutic approach for many dogs with cervical fractures. Early neck immobilization and prompt referral are recommended, because delay in referral decreases the likelihood of functional recovery.
A fast parallel algorithm for the solution of tridiagonal linear systems (1992)

We present a parallel algorithm for the solution of tridiagonal linear systems based on the method of partitioning and backward elimination. A given N × N system is partitioned into r blocks each of size n × n (N = rn n even). Within each block the system is rewritten by collecting pairs of equations from the top and bottom (written backwards); this makes it suitable to solve the subsystem by a UL-factorization of its coefficient matrix. Once a core system of size 2r × 2r has been solved, solutions of the r subsystems can be computed in parallel. Interestingly, the serial arithmetical operations count for the present algorithm is 0(1612;N); this makes it faster than the quadrant interlocking factorization method of Chawla and Passi [1], the partitioning method of Wang [7] and cyclic reduction (see Hockney and Jesshope [6, p. 479]), each of which has a serial count of 0(17N).