gebhart/patrepeval huggingface dataset:
Identifying Connectivity Patterns for Brain Diseases via Multi-side-view Guided Deep Architectures (2016)

There is considerable interest in mining neuroimage data to discover clinically meaningful connectivity patterns to inform an understanding of neurological and neuropsychiatric disorders. Subgraph mining models have been used to discover connected subgraph patterns. However, it is difficult to capture the complicated interplay among patterns. As a result, classification performance based on these results may not be satisfactory. To address this issue, we propose to learn non-linear representations of brain connectivity patterns from deep learning architectures. This is non-trivial, due to the limited subjects and the high costs of acquiring the data. Fortunately, auxiliary information from multiple side views such as clinical, serologic, immunologic, cognitive and other diagnostic testing also characterizes the states of subjects from different perspectives. In this paper, we present a novel Multi-side-View guided AutoEncoder (MVAE) that incorporates multiple side views into the process of deep learning to tackle the bias in the construction of connectivity patterns caused by the scarce clinical data. Extensive experiments show that MVAE not only captures discriminative connectivity patterns for classification, but also discovers meaningful information for clinical interpretation.
Bus-invert coding for low-power I/O - a decomposition approach (2002)

This paper proposes a new bus-invert coding scheme for reducing the number of bus transitions. Unlike the previous schemes in which the entire bus lines or one subset of the bus fines are considered for bus-invert coding, in the proposed scheme the bus lines are partitioned and each partitioned group is considered independently for bus-invert coding to maximize the effectiveness of reducing the total number of bus transitions. Experimental results show that the decomposed bus-invert coding scheme reduces the total number of bus transitions by 47.2% and 11.9% on average than those of the conventional and the partial bus-invert coding schemes, respectively
Temporary acidosis during reperfusion limits myocardial infarct size in dogs (1997)

We tested the hypothesis that myocardial extracellular acidosis during early reperfusion limits infarct size. The left anterior descending coronary artery was perfused with blood through a bypass tube in dogs. We occluded the bypass tube for 40 (protocol I; n = 24 hearts) and 90 min (protocol II; n = 36 hearts). In protocols I and II, we infused one group of hearts with HCl (60 micrograms.kg-1.min-1) for 60 min after the onset of reperfusion (the metabolic acidosis group), and another group of hearts were ventilated with 3 liters of 70% O2-30% CO2 mixed with room air 10 min before the onset of reperfusion for 70 min (the respiratory acidosis group). pH in the coronary venous blood and myocardial pH during reperfusion in the metabolic and respiratory acidosis groups were lower than those in the control groups. Infarct sizes in the metabolic (16.4 +/- 2.5 and 22.3 +/- 2.5%) and respiratory (16.7 +/- 2.6 and 22.3 +/- 2.5%) acidosis groups in protocols I and II, respectively, were smaller than those in the control groups (33.1 +/- 3.0 and 40.6 +/- 4.1%, respectively). Thus we conclude that temporary acidosis during reperfusion limits infarct size.
Hybrid Micropower Source for Wireless Sensor Network (2008)

Wireless sensor networks have become a very significant enabling technology in many applications and the use of environmental energy is a feasible source for low-power wireless sensor networks. The challenges of developing a power supply including generation or conversion, storage, and power management are manifold to extend the lifetime of a wireless sensor network. The objective of this research is to develop an intelligent hybrid power system to realize a self-sustaining wireless sensor node. The photovoltaic and thermoelectric generators are adopted as energy converters. The lithium ion battery and ultracapacitor are used as reservoirs. An intelligent power management system has been developed to control the power distribution. The design data and experimental results show that the hybrid micropower source can extend the lifetime of a sensor network.
Conga: ¿qué significaría quererse? (2012)

Cunto ya ha sido dicho sobre Conga en estos meses, cunto se ha hecho en diferentes frentes y niveles, cuntos actores y recursos movilizados.Y sin embargo, no
Nonspecific and specific immunological mitogenicity by group A streptococcal pyrogenic exotoxins (1978)

Group A streptococcal pyrogenic exotoxin (SPE) types A, B, and C induced lymphocyte proliferation both specifically and nonspecifically, and the responses showed characteristics associated with both types of stimulation. Guinea pig lymphocytes from animals presensitized to SPE A displayed immunologically specific proliferation in response to SPE A; control lymphocytes showed little activity in the presence of SPE A. Lymphocytes from guinea pigs not presensitized to SPE responded nonspecifically to SPE types B and C. Guinea pig lymphocytes from SPE A-presensitized animals showed enhanced proliferation over controls when treated with SPE B, suggesting that a degree of cross-reactivity between SPE types may exist, though they are serologically distinct. Mouse splenic lymphocytes exhibited low-level responsiveness to all SPE types, as would be expected for an antigen-specific proliferative response. Unlike mouse splenic lymphocytes, rabbit spleen cells and human cord blood, lymphocytes responded nonspecifically to all SPE types. Although rabbit spleen cells and human cord blood lymphocytes responded nonspecifically, the maximum response occurred at day 4 or 5, comparable to an antigen-specific system rather than a day 2 or 3 such as that with the nonspecific thymus-derived cell mitogen, concanavalin A.
Vascular endothelial growth factor is upregulated by l-dopa in the parkinsonian brain: implications for the development of dyskinesia (2011)

Angiogenesis and increased permeability of the blood-brain barrier have been reported to occur in animal models of Parkinson's disease and l-dopa-induced dyskinesia, but the significance of these phenomena has remained unclear. Using a validated rat model of l-dopa-induced dyskinesia, this study demonstrates that chronic treatment with l-dopa dose dependently induces the expression of vascular endothelial growth factor in the basal ganglia nuclei. Vascular endothelial growth factor was abundantly expressed in astrocytes and astrocytic processes in the proximity of blood vessels. When co-administered with l-dopa, a small molecule inhibitor of vascular endothelial growth factor signalling significantly attenuated the development of dyskinesia and completely blocked the angiogenic response and associated increase in blood-brain barrier permeability induced by the treatment. The occurrence of angiogenesis and vascular endothelial growth factor upregulation was verified in post-mortem basal ganglia tissue from patients with Parkinson's disease with a history of dyskinesia, who exhibited increased microvascular density, microvascular nestin expression and an upregulation of vascular endothelial growth factor messenger ribonucleic acid. These congruent findings in the rat model and human patients indicate that vascular endothelial growth factor is implicated in the pathophysiology of l-dopa-induced dyskinesia and emphasize an involvement of the microvascular compartment in the adverse effects of l-dopa pharmacotherapy in Parkinson's disease.
Acridinium Salt-Based Fluoride and Acetate Chromofluorescent Probes: Molecular Insights into Anion Selectivity Switching (2009)

A series of acridinium salt-based probes capable of detecting fluoride and acetate anions via a nucleophilic attack at the C9 position of the acridinium moiety is reported. The formation of corresponding acridane displays drastic changes, in both UV-vis absorption and fluorescence emission. The sensing mechanism is a reversible process upon treating either tetrafluoroborate salt or an acid.
Effects of GLP-1 on Forearm Vasodilator Function and Glucose Disposal During Hyperinsulinemia in the Metabolic Syndrome (2012)

In patients with the MetS, GLP-1 improves insulin-mediated enhancement of endothelium-dependent and -independent vascular reactivity. This effect may be influenced by vascular oxidative stress and is possibly exerted through a receptor-mediated mechanism.
T cells conditioned with MDSC show an increased anti-tumor activity after adoptive T cell based immunotherapy (2016)

The success of adoptive T cell-based immunotherapy (ACT) in cancer is limited in part by the accumulation of myeloid-derived suppressor cells (MDSC), which block several T cell functions, including T cell proliferation and the expression of various cytotoxic mediators. Paradoxically, the inhibition of CD8+ T cell differentiation into cytotoxic populations increased their efficacy after ACT into tumor-bearing hosts. Therefore, we aimed to test the impact of conditioning CD8+ T cells with MDSC on their differentiation potential and ACT efficacy. Our results indicate that MDSC impaired the progression of CD8+ T cells into effector populations, without altering their activation status, production of IL-2, or signaling through the T cell receptor. In addition, culture of CD8+ T cells with MDSC resulted in an increased ACT anti-tumor efficacy, which correlated with a higher frequency of the transferred T cells and elevated IFNγ production. Interestingly, activated CD62L+ CD8+ T cells were responsible for the enhanced anti-tumor activity showed by MDSC-exposed T cells. Additional results showed a decreased protein synthesis rate and lower activity of the mammalian/mechanistic target of rapamycin (mTOR) in T cells conditioned with MDSC. Silencing of the negative mTOR regulator tuberous sclerosis complex-2 in T cells co-cultured with MDSC restored mTOR activity, but resulted in T cell apoptosis. These results indicate that conditioning of T cells with MDSC induces stress survival pathways mediated by a blunted mTOR signaling, which regulated T cell differentiation and ACT efficacy. Continuation of this research will enable the development of better strategies to increase ACT responses in cancer.
A method for hunting bugs that occur due to system conflicts (2008)

A very important class of bugs that occurs in VLSI projects, and especially in System on Chip (SoC) type projects, are bugs caused by two or more processes on chip trying to access a shared resource simultaneously. These kinds of bugs are both hard to find and very likely have the potential to cause a respin if not found since it is very hard to work around them in software (SW). In this paper we present a framework to define such conflict cases and a tool for automatically generating test cases from this definition. We have implemented this framework and tool, generated test suites, and simulated them on the Design Under Verification. Our method immediately proved its effectiveness by catching an unknown problem in a project which has already established a reasonable test suite regression that is simulated periodically.
Using FIRE & ICE for Detecting and Recovering Compromised Nodes in Sensor Networks (2004)

Abstract : This paper presents a suite of protocols called FIRE (Forgery-resilient Intrusion detection, Recovery, and Establishments of keys), for detecting and recovering compromised nodes in sensor networks. FIRE consists of two protocols: an intrusion detection and code update protocol, and a cryptographic key update protocol. In concert, the FIRE protocols enable us to design a sensor network that can always detect compromised nodes (no false negatives), and either repair them through code updates and set up new cryptographic keys, or revoke the compromised nodes from the network. The FIRE protocols are based on ICE (Indisputable Code Execution), a mechanism providing externally verifiable code execution on off-the-shelf sensor nodes. ICE gives the following two properties: 1) the locations in memory from where the code is currently executing on a sensor node, matches memory locations being verified and 2) the memory contents being verified are correct. Together, these two properties guarantee that the code currently executing on the sensor node is correct. The FIRE protocols represent a significant step towards designing secure sensor networks. As far as we are aware, there are no techniques for intrusion detection in adhoc and sensor networks that do make any false negative claims. Also, we do not know of any existing techniques that can automatically recover compromised sensor nodes. We present an implementation of our FIRE protocols and ICE on current off-the-shelf sensor devices.
A simple local-control approximation algorithm for multicommodity flow (2002)

In this paper, we describe a very simple (1+/spl epsi/)-approximation algorithm for the multicommodity flow problem. The algorithm runs in time that is polynomial in N (the number of nodes in the network) and /spl epsiv//sup -1/ (the closeness of the approximation to optimal). The algorithm is remarkable in that it is much simpler than all known polynomial time flow algorithms (including algorithms for the special case of one-commodity flow). In particular, the algorithm does not rely on augmenting paths, shortest paths, min-cost paths, or similar techniques to push flow through a network. In fact, no explicit attempt is ever made to push flow towards a sink during the algorithm. Because the algorithm is so simple, it can be applied to a variety of problems for which centralized decision making and flow planning is not possible. For example, the algorithm can be easily implemented with local control in a distributed network and it can be made tolerant to link failures. In addition, the algorithm appears to perform well in practice. Initial experiments using the DIMACS generator of test problems indicate that the algorithm performs as well as or better than previously known algorithms, at least for certain test problems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Gene expression profiling of early involuting mammary gland reveals novel genes potentially relevant to human breast cancer (2006)

Mammary gland involution represents one of the most dramatic examples of programmed cell death/apoptosis and tissue regression during development, yet large gaps still exist in the understanding of the mechanisms involved, and the key factors that trigger involution, are not yet identified. With the focus on identifying "novel" genes associated with mammary gland regression, we used microarray analysis to examine differentially expressed genes during early mammary gland involution in the mouse. We then examined the relevance of candidate genes to human tumorigenesis and identified a number of genes not previously implicated or not well characterized in human breast cancer. The expression levels of these genes in human breast cancer were confirmed in breast cancer cell lines and breast tumor tissues. This pilot study demonstrates proof of principle that through the analysis of gene expression during mammary gland involution, it may be possible to identify "novel" genes relevant human breast cancer.
Visual Cortex Excitability in Migraine With and Without Aura (2001)

Objectives.—Previous research using transcranial magnetic stimulation has produced equivocal findings concerning thresholds for the generation of visual phosphenes in migraine with aura. These studies were methodologically varied and did not systematically address cortical excitability in migraine without aura. We therefore studied magnetophosphene thresholds in both migraine with aura and migraine without aura compared with headache‐free controls. Methods.—Sixteen subjects with migraine with aura and 12 subjects with migraine without aura were studied and compared with 16 sex‐ and age‐matched controls. Using a standardized transcranial magnetic stimulation protocol of the occipital cortex, we assessed the threshold stimulation intensity at which subjects just perceived phosphenes via a method of alternating course and fine‐tuning of stimulator output. Results.—There were no significant differences across groups in the proportion of subjects seeing phosphenes. However, the mean threshold at which phosphenes were reported was significantly lower in both migraine groups (migraine with aura = 47%, migraine without aura = 46%) than in controls (66%). Moreover, there was no significant correlation between individual phosphene threshold and the time interval to the closest migraine attack. Conclusion.—Our findings confirm that the occipital cortex is hyperexcitable in the migraine interictum, both in migraine with and without aura.
Intestinal CD103+CD4+ and CD103+CD8+ T-Cell Subsets in the Gut of Inflammatory Bowel Disease Patients at Diagnosis and During Follow-up (2019)

At diagnosis, active inflammation in IBD was associated with decreased percentages of both CD103+CD4+ and CD103+CD8+T-cell subsets in colon and ileum biopsies. In active disease during follow-up, these T-cell populations remained low but increased in remission to values comparable with healthy controls. A shift toward more CD103-T cells was observed during active inflammation.
Association of newly synthesized major fl coat protein with infected host cell inner membrane (1972)

Abstract The bacteriophage fl major coat protein becomes associated with the host cell inner membrane very shortly after it is synthesized. Pulse‐chase experiments suggest that the virus is never stably associated with the host cell outer membrane; we propose that it passes directly from the inner membrane to the growth medium.
A pressure mat for preventing pressure sores (2003)

Using a 0.4-mm thick Interlink conductive polymer pressure sensor, the pressure distribution under the buttocks was measured. The measured pressures under the ischial tuberosities were much higher when the subject was seated on a table than when seated on a cushion. A pressure mat incorporating an array of these sensors, to be placed under any bony protuberance, is proposed. When the pressure-time profile of any sensor exceeds safe limits, an alarm would be provided to the patient or caregiver. It is believed that this pressure mat could reduce the incidence of pressure sores in the spinal-cord injured, in the elderly, and in the operating room.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
SocialNetCrawler (2019)

The emergence and popularization of on-line social networks suddenly made available a large amount of data from social organization, interaction and human behavior. All this information opens new perspectives and challenges to the study of social systems, being of interest to many fields. Although most on-line social networks are recent, a vast amount of scientific papers was already published on this topic, dealing with a broad range of analytical methods and applications. Therefore, the development of a tool capable of gather tailored information from social networks is something that can help a lot of researchers on their work, especially in the area of Natural Language Processing (NLP). Nowadays, the daily base medium where people use more often text language lays precisely on social networks. Therefore, the ubiquitous crawling of social networks is of the utmost importance for researchers. Such a tool will allow the researcher to get the relevant needed information, allowing a faster research in what really matters, without loosing time on the development of his own crawler. In this paper, we present an extensive analysis of the existing social networks and their APIs, and also describe the conception and design of a social network crawler which will help NLP researchers.
Gas source molecular beam epitaxy grown InGaAs(P)N-InP long-wavelength (/spl lambda/>1.65 μm) photodetectors using a solid arsenic source (2001)

We demonstrate InGaAs(P)N-InP-based long-wavelength (/spl lambda/>1.65 μm) p-i-n photodetectors grown lattice-matched to InP substrates using a solid As source. The background doping level in the absorption layer is significantly reduced from (5.0/spl plusmn/0.3)×10/sup 17/ cm/sup -3/ for gas source As grown devices to (3.5/spl plusmn/0.5)×10/sup 16/ cm/sup -3/ for solid source As grown devices with the same cutoff wavelength of 1.85 μm. The external quantum efficiency at a wavelength of 1.56 μm is 30% for the solid source grown detector as compared with 16% for the gas source grown detector due to the higher background doping and hence smaller depletion region width in the latter diode. Nitrogen-hydrogen complex formation and local strain-induced defects may significantly contribute to high free carrier concentrations observed in gas source As grown InGaAs(P)N layers.
Hormonprofilveränderungen unter DHEA-Substitution bei Patienten mit erektiler Dysfunktion (2001)

Dehydroepiandrosteron (DHEA) ist das verbreitetste Hormon im menschlichen Körper und wird der Gruppe der Steroidhormone zugeordnet. Nach Bildung in der Zona reticularis der Nebennierenrinde wird es mit Hilfe des Leberenzyms Dehydroepiandrosteronsulfotransferase in das Sulfat Dehydroepiandrosteronsulfat (DHEAS) umgewandelt, zirkuliert so relativ stabil im Blut und wird in die Sexualhormone Testosteron und Östrogen im Gewebe transformiert. Eine bisher wissenschaftlich nicht abgeklärte Frage ist die Wirkung einer DHEA-Substitution auf die Serumspiegel der Sexualhormone beim Mann. Zu diesem Zweck wurden an allen Patienten mit ED, die an unserer Klinik und in zwei urologischen Kassenpraxen dieser Hormonsubstitution unterzogen wurden, im Rahmen einer prospektiven Studie ein Monitoring der wichtigsten Sexualhormone durchgeführt. Zwischen Oktober 1997 und Februar 2000 wurden 187 Patienten mit einem mittleren Alter von 52,4 Jahren, welche primär unsere Ambulanz oder zwei urologische Kassenpraxen wegen einer ED aufsuchten, nach urologischer und endokrinologischer Abklärung in diese prospektive, offene Studie aufgenommen. Alle Patienten wurden sorgfältig auf medizinische Faktoren untersucht, die einen Einfluß auf endokrinologische Abläufe haben könnten. Jeder Patient wurde mit einer Kapsel DHEA 50 mg 1 x 1 tgl. therapiert und für einen geplanten Studienzeitraum von 6 Monaten in die Studie aufgenommen. Eine statistisch signifikante Veränderung zeigten nur die Östradiolwerte. Dieser Anstieg schon begann 3 Monaten und diese Tendenz wurde bis zum Studienende beibehalten. Es konnte in dieser prospektiven Studie erstmalig in einem großen Patientenkollektiv gezeigt werden, daß sich bei männlichen Patienten mit erektiler Dysfunktion nach Substitutionstherapie mit 50 mg DHEA einmal tgl. eine statistisch signifikante Steigerung der Östradiolwerte, jedoch keine Veränderung der Testosteronwerte nachweisen läßt. Ob nun die DHEA-Wirkung beim ED-Patienten durch zentralnervöse Wirkungsmechanismen oder durch eine periphere Östrogenwirkung zu erfolgt, ist derzeit leider nur hypothetisch und durch weitere Forschungsarbeit abzuklären.