gebhart/patrepeval huggingface dataset:
Food-Specific Attribution of Selected Gastrointestinal Illnesses: Estimates from a Canadian Expert Elicitation Survey (2011)

The study used a structured expert elicitation survey to derive estimates of food-specific attribution for nine illnesses caused by enteric pathogens in Canada. It was based on a similar survey conducted in the United States and focused on Campylobacter spp., Escherichia coli O157:H7, Listeria monocytogenes, nontyphoidal Salmonella enterica, Shigella spp., Vibrio spp., Yersinia enterocolitica, Cryptosporidium parvum, and Norwalk-like virus. A snowball approach was used to identify food safety experts within Canada. Survey respondents provided background information as well as self-assessments of their expertise for each pathogen and the 12 food categories. Depending on the pathogen, food source attribution estimates were based on responses from between 10 and 35 experts. For each pathogen, experts divided their estimates of total foodborne illness across 12 food categories and they provided a best estimate for each category as well as 5th and 95th percentile limits for foods considered to be vehicles. Their responses were treated as triangular probability distributions, and linear aggregation was used to combine the opinions of each group of experts for each pathogen-food source group. Across the 108 pathogen-food groups, a majority of experts agreed on 30 sources and 48 nonsources for illness. The number of food groups considered to be pathogen sources by a majority of experts varied by pathogen from a low of one food source for Vibrio spp. (seafood) and C. parvum (produce) to a high of seven food sources for Salmonella spp. Beta distributions were fitted to the aggregated opinions and were reasonable representations for most of the pathogen-food group attributions. These results will be used to quantitatively assess the burden of foodborne illness in Canada as well as to analyze the uncertainty in our estimates.
Colloidal Gold-Modified Optical Fiber for Chemical and Biochemical Sensing (2002)

A novel class of fiber-optic evanescent-wave sensor was constructed on the basis of modification of the unclad portion of an optical fiber with self-assembled gold colloids. The optical properties and, hence, the attenuated total reflection spectrum of self-assembled gold colloids on the optical fiber changes with different refractive index of the environment near the colloidal gold surface. With sucrose solutions of increasing refractive index, the sensor response decreases linearly. The colloidal gold surface was also functionalized with glycine, succinic acid, or biotin to enhance the selectivity of the sensor. Results show that the sensor response decreases linearly with increasing concentration of each analyte. When the colloidal gold surface was functionalized with biotin, the detection limit of the sensor for streptavidin was 9.8 x 10(-11) M. Using this approach, we demonstrate proof-of-concept of a class of refractive index sensor that is sensitive to the refractive index of the environment near the colloidal gold surface and, hence, is suitable for label-free detection of molecular or biomolecular binding at the surface of gold colloids.
Risk stratification in multiple myeloma, part 2: the significance of genetic risk factors in the era of currently available therapies. (2013)

Multiple myeloma (MM) is a heterogeneous disease, and a variety of risk factors at the time of initial diagnosis can be used to stratify patients. In the first part of this 2-part series, we reviewed the currently identified prognostic factors, characterized by disease burden, host factors, tumor biology, and depth of response to therapy. However, these risk factors cannot be interpreted independently of therapies. Novel therapies have the potential to worsen or improve outcomes compared with conventional therapy in high-risk patients, or actually overcome the high-risk status, thereby resulting in reclassification as standard risk. For example, thalidomide (Thalomid, Celgene) is associated with worse outcomes in patients with high-risk cytogenetic abnormalities, such as deletion of chromosomes 13 and 17p, whereas proteasome inhibitors appear to overcome t(4;14). The second part of this series reviews the significance of various genetic risks in the era of novel therapies for MM.
A CMOS analog front-end processor for an FDM system (2002)

A five channel analog front-end processor for a frequency division multiplexed (FDM) system is described. Each channel has a low-noise, two stage programmable-gain amplifier with a gain range of 15-35 dB in 1 dB steps, followed by a fifth-order elliptic switched-capacitor low-pass filter with a band edge of 300 kHz. A four-input amplifier has been designed for the first gain stage. This achieves fully balanced gain with a high input impedance. An exact design technique has been used to realize the filter. An analog multiplexer time-multiplexes the five channels with a crosstalk suppression of better than 70 dB. The chip also has a microprocessor interface, and timing and control circuitry. Fully differential topology has been used to obtain a dynamic range of 70 dB, signal-to-distortion ratio of 68 dB, and a power supply rejection ratio of 85 dB. The chip uses a 2.25 mu m gate-length, 5 V technology, and has a power dissipation of only 390 mW.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Lean and zoom (2008)

The size and resolution of computer displays has increased dramatically, allowing more information than ever to be rendered on-screen. However, items can now be so small or screens so cluttered that users need to lean forward to properly examine them. This behavior may be detrimental to a user's posture and eyesight. Our Lean and Zoom system detects a user's proximity to the display using a camera and magnifies the on-screen content proportionally. This alleviates dramatic leaning and makes items more readable. Results from a user study indicate people find the technique natural and intuitive. Most participants found on-screen content easier to read, and believed the technique would improve both their performance and comfort.
Redox signaling and splicing dependent change in myosin phosphatase underlie early versus late changes in NO vasodilator reserve in a mouse LPS model of sepsis (2015)

Microcirculatory dysfunction may cause tissue malperfusion and progression to organ failure in the later stages of sepsis, but the role of smooth muscle contractile dysfunction is uncertain. Mice were given intraperitoneal LPS, and mesenteric arteries were harvested at 6-h intervals for analyses of gene expression and contractile function by wire myography. Contractile (myosin and actin) and regulatory [myosin light chain kinase and phosphatase subunits (Mypt1, CPI-17)] mRNAs and proteins were decreased in mesenteric arteries at 24 h concordant with reduced force generation to depolarization, Ca(2+), and phenylephrine. Vasodilator sensitivity to DEA/nitric oxide (NO) and cGMP under Ca(2+) clamp were increased at 24 h after LPS concordant with a switch to Mypt1 exon 24- splice variant coding for a leucine zipper (LZ) motif required for PKG-1α activation of myosin phosphatase. This was reproduced by smooth muscle-specific deletion of Mypt1 exon 24, causing a shift to the Mypt1 LZ+ isoform. These mice had significantly lower resting blood pressure than control mice but similar hypotensive responses to LPS. The vasodilator sensitivity of wild-type mice to DEA/NO, but not cGMP, was increased at 6 h after LPS. This was abrogated in mice with a redox dead version of PKG-1α (Cys42Ser). Enhanced vasorelaxation in early endotoxemia is mediated by redox signaling through PKG-1α but in later endotoxemia by myosin phosphatase isoform shifts enhancing sensitivity to NO/cGMP as well as smooth muscle atrophy. Muscle atrophy and modulation may be a novel target to suppress microcirculatory dysfunction; however, inactivation of inducible NO synthase, treatment with the IL-1 antagonist IL-1ra, or early activation of α-adrenergic signaling did not suppressed this response.
Deployable structures Concepts and analysis (1994)

Available from British Library Document Supply Centre-DSC:D063936 / BLDSC - British Library Document Supply Centre
The lipid lowering effect of plant sterol ester capsules in hypercholesterolemic subjects (2007)

In conclusion, plant sterol ester capsule is effective in improving lipid profiles among hypercholesterolemic subjects in a free-living setting at the minimum dosage recommended by FDA. The significant improved lipid profiles were reached after three weeks of administration. To achieve better lipid lowering results, higher dosages and combination with diets low in saturated fat and cholesterol are recommended.
Sentence-Chain Based Seq2seq Model for Corpus Expansion (2017)

This study focuses on a method for sequential data augmentation in order to alleviate data sparseness problems. Specifically, we present corpus expansion techniques for enhancing the coverage of a language model. Recent recurrent neural network studies show that a seq2seq model can be applied for addressing language generation issues; it has the ability to generate new sentences from given input sentences. We present a method of corpus expansion using a sentence‐chain based seq2seq model. For training the seq2seq model, sentence chains are used as triples. The first two sentences in a triple are used for the encoder of the seq2seq model, while the last sentence becomes a target sequence for the decoder. Using only internal resources, evaluation results show an improvement of approximately 7.6% relative perplexity over a baseline language model of Korean text. Additionally, from a comparison with a previous study, the sentence chain approach reduces the size of the training data by 38.4% while generating 1.4‐times the number of n‐grams with superior performance for English text.
RAPID EXCAVATION OF ROCK WITH SMALL CHARGES OF HIGH EXPLOSIVE. OPEN FILE REPORT (1980)

The purpose of this investigation was to test a blast shield, develop a conceptual design for an automated drill and blast system (ADBS), and make an economic analysis of the ADBS compared with conventional drill, blast, and muck (DBM) systems. The ADBS tunneling concept was developed in an effort to design an excavation system of greater efficiency than the DBM system conventionally used. The ADBS would minimize downtime and approach noncyclic efficiently by small charge blasting. Small charge blasting uses simultaneously detonated light charges in four to eight short holes, usually in a line. Limitation of the total explosive per blast reduced air blast overpressure, fly rock velocity, vibrations, and noise enabling the blast shield to adequately contain these side effects. Conceptual design for the ADBS included blast shield, chasis, hydraulic drills, automated explosive loading and firing system, and an armored cab. Horizontal and vertical blast shield alinement controls and ventilation are incorporated into the design. The economic analysis determined ADBS advance costs to be 17 to 20 pct lower than DBM on a per foot basis.
HSV-2 Vaccine: Current Status and Insight into Factors for Developing an Efficient Vaccine (2014)

Herpes simplex virus type 2 (HSV-2), a globally sexually transmitted virus, and also one of the main causes of genital ulcer diseases, increases susceptibility to HIV-1. Effective vaccines to prevent HSV-2 infection are not yet available, but are currently being developed. To facilitate this process, the latest progress in development of these vaccines is reviewed in this paper. A summary of the most promising HSV-2 vaccines tested in animals in the last five years is presented, including the main factors, and new ideas for developing an effective vaccine from animal experiments and human clinical trials. Experimental results indicate that future HSV-2 vaccines may depend on a strategy that targets mucosal immunity. Furthermore, estradiol, which increases the effectiveness of vaccines, may be considered as an adjuvant. Therefore, this review is expected to provide possible strategies for development of future HSV-2 vaccines.
Presynaptic ionotropic receptors (1996)

Recent studies have provided new insights into the role of presynaptic ligand-gated ion channels in modifying synaptic transmission. Along with a growing list of different types of presynaptic ionotropic receptors and the cell types that express them, there have been advances in characterizing the molecular components of the receptors as well as the signaling processes that link receptor activation to changes in neurotransmitter release. Perhaps most striking is the recent convergence of data from biochemical, molecular and electrophysiological studies, implicating presynaptic ionotropic receptors in the effects of psychoactive and addictive drugs.
Fuzzy Measures on the Gene Ontology for Gene Product Similarity (2006)

One of the most important objects in bioinformatics is a gene product (protein or RNA). For many gene products, functional information is summarized in a set of Gene Ontology (GO) annotations. For these genes, it is reasonable to include similarity measures based on the terms found in the GO or other taxonomy. In this paper, we introduce several novel measures for computing the similarity of two gene products annotated with GO terms. The fuzzy measure similarity (FMS) has the advantage that it takes into consideration the context of both complete sets of annotation terms when computing the similarity between two gene products. When the two gene products are not annotated by common taxonomy terms, we propose a method that avoids a zero similarity result. To account for the variations in the annotation reliability, we propose a similarity measure based on the Choquet integral. These similarity measures provide extra tools for the biologist in search of functional information for gene products. The initial testing on a group of 194 sequences representing three proteins families shows a higher correlation of the FMS and Choquet similarities to the BLAST sequence similarities than the traditional similarity measures such as pairwise average or pairwise maximum.
A new biomedical device for in vivo multiparametric evaluation of tissue vitality in critical care medicine (2005)

Real time Monitoring of mitochondrial function in vivo is a significant factor in the understanding of tissue vitality. Nevertheless a single parameter monitoring device is not appropriate and effective in clinical diagnosis of tissue vitality. Therefore we have developed a multi-parametric monitoring system that monitors, in addition to mitochondrial NADH redox state, tissue microcirculatory blood flow, tissue total back-scattered light as an indication of blood volume and blood oxygenation (Hb0<sub>2</sub>). In the present communication a new device named "CritiView" is described. This device was developed in order to enable real time monitoring of the four parameters from various organs in the body. The main medical application of the CritiView is in critical care medicine of patients hospitalized in the Intensive Care Units (ICUs) and intraoperatively in operating rooms. The physiological basis for our clinical monitoring approach is based on the well known response to the development of body emergency situation, such as shock or trauma. Under such conditions a process of blood flow redistribution will give preference to vital organs (Brain, Heart) neglecting less vital organs (Skin, G-I tract or the urinary system). Under such condition the brain will by hyperperfused and O<sub>2</sub> supply will increase to provide the need of the activated mitochondria. The non-vital organs will be hypoperfused and mitochondial function will be inhibited leading to energy failure. This differentiation between the two types of organs could be used for the early detection of body deterioration by monitoring of the non-vital organ vitality. A fiber optic sensor was embedded in a Foley catheter, enabling the monitoring of Urethral wall vitality, to serve as an early warning signal of body deterioration.
Role of EGF receptor transactivation in phosphoinositide 3‐kinase‐dependent activation of MAP kinase by GPCRs (2005)

Many G protein coupled receptors (GPCRs) cause phosphorylation of MAP kinases through transactivation of the epidermal growth factor receptor (EGF-R), leading to increased cell survival and growth, motility, and migration. Phosphoinositide 3-kinase (PI3K) is one of the important cell survival signaling molecules activated by EGF-R stimulation. However, the extent to which EGF-R transactivation is essential for GPCR agonist-stimulated PI3K activation is not known. Here we examined the mechanism of PI3K activation that elicits GPCR-mediated ERK1/2 activation by pathways dependent and/or independent of EGF-R transactivation in specific cell types. Immortalized hypothalamic neurons (GT1-7 cells) express endogenous gonadotropin-releasing hormone receptors (GnRH-R) and their stimulation causes marked phosphorylation of ERK1/2 and Akt (Ser 473) through transactivation of the EGF-R and recruitment of PI3K. In C9 hepatocytes, agonist activation of AT1 angiotensin II (AT1-R), lysophosphatidic acid (LPA), and EGF receptors caused phosphorylation of Akt through activation of the EGF-R in a PI3K-dependent manner. However, ERK1/2 activation by these agonists in these cells was independent of PI3K activation. In contrast, agonist stimulation of HEK 293 cells stably expressing AT1-R caused ERK1/2 phosphorylation that was independent of EGF-R transactivation but required PI3K activation. LPA signaling in these cells showed partial and complete dependence on EGF-R and PI3K, respectively. These data indicate that GPCR-induced ERK1/2 phosphorylation is dependent or independent of PI3K in specific cell types, and that the involvement of PI3K during ERK1/2 activation is not dependent solely on agonist-induced transactivation of the EGF-R.
Lateral Specialization of Cognitive Mode: An EEG Study (1972)

ABSTRACT We have studied EEG asymmetry in normal subjects during verbal and spatial tasks. Recordings were made from the left and right temporal and parietal areas, and the ratios of average power (1–35 Hz) in homologous leads T 4 /T 3 and P 4 /P 3 were computed. This ratio (right over left) was greater in the verbal tasks than in the spatial tasks. With this measure we have been able to distinguish between these two cognitive modes as they occur in normal subjects, using simple scalp recording.
Feedback control in active sensing: rat exploratory whisking is modulated by environmental contact (2007)

Rats sweep their facial whiskers back and forth to generate tactile sensory information through contact with environmental structure. The neural processes operating on the signals arising from these whisker contacts are widely studied as a model of sensing in general, even though detailed knowledge of the natural circumstances under which such signals are generated is lacking. We used digital video tracking and wireless recording of mystacial electromyogram signals to assess the effects of whisker-object contact on whisking in freely moving animals exploring simple environments. Our results show that contact leads to reduced protraction (forward whisker motion) on the side of the animal ipsilateral to an obstruction and increased protraction on the contralateral side. Reduced ipsilateral protraction occurs rapidly and in the same whisk cycle as the initial contact. We conclude that whisker movements are actively controlled so as to increase the likelihood of environmental contacts while constraining such interactions to involve a gentle touch. That whisking pattern generation is under strong feedback control has important implications for understanding the nature of the signals reaching upstream neural processes.
Multicast ATM Switch with Feedback Input Queuing, Priority Sorting Network, and Output Queuing (1994)

The design of multicast ATM switch is presented. The switch is constructed from input queuing, a multicast copy network, a self non-blocking interconnection network, a feedback routing network and output queuing. The switch operates with internal speed-up using multiple routing networks in parallel. This switch provides simultaneous reception of information from separate sources, simultaneous transmission of different information destined to different output ports, and feedback for packets that lose the contention for the same output Multicast copy network has been placed at the feed forward path with separate input queuing. Contrast to other designs where the copy network can duplicate one copy during one time slot, in this design the copy network can duplicate multicast packets up to the number of routing network at one time slot, maximising throughput and decreasing the delay at the input queue. Packet mean delay, and loss performance at the queue are evaluated, and simulation results of the switch under bursty traffic is evaluated. The simulation and analytical results have shown high performance in terms of low probability of packet loss, low mean delay, sequence integrity and low cost.
An alignment-free fiber-coupled microsphere resonator for gas sensing applications (2010)

In this paper we report on the assembly of a robust sensor system consisting of a polystyrene microsphere resonator attached to an optical fiber taper. Since the sphere is only supported by the micrometer-sized fiber no further alignment is necessary. This results in a thermally and mechanically well isolated optical resonator system with quality factors as high as 6×105. The narrow resonances of whispering gallery modes supported by the polystyrene resonators shift with temperature at a rate of 3.8 GHz/K. Thus, a sensitive thermometer is established which allows to detect the surrounding gas via its characteristic thermal conductivity.
Parameter-free auto-weighted multiple graph learning: a framework for multiview clustering and semi-supervised classification (2016)

<p>\n\tGraph-based approaches have been successful in unsupervised and semi-supervised learning. In this paper, we focus on the real-world applications where the same instance can be represented by multiple heterogeneous features. The key point of utilizing the graph-based knowledge to deal with this kind of data is to reasonably integrate the different representations and obtain the most consistent manifold with the real data distributions. In this paper, we propose a novel framework via the reformulation of the standard spectral learning model, which can be used for multiview clustering and semisupervised tasks. Unlike other methods in the literature, the proposed methods can learn an optimal weight for each graph automatically without introducing an additive parameter as previous methods do. Furthermore, our objective under semisupervised learning is convex and the global optimal result will be obtained. Extensive empirical results on different real-world data sets demonstrate that the proposed methods achieve comparable performance with the state-of-the-art approaches and can be used more practically.</p>
Effects of UV-light on Bacillus sphaericus and its protection by chemicals (2000)

Although when UV-irradiated seven most toxic strains of Bacillus sphaericus lost their viabilities between 2.5-4.5 min, their larvicidal activity was protected for longer periods. Benzaldehyde, cinnamaldehyde, salicylaldehyde, methylene blue and yeast extract showed good protective effect for spore viability and larvicidal activity from UV inactivation in B. sphaericus. This protective effect has also been confirmed by SDS-PAGE analyses whereby the 42 kDa and 51 kDa toxic proteins bands did not disappear following UV treatment.