gebhart/patrepeval huggingface dataset:
Heritable Gene Repression through the Action of a Directed DNA Methyltransferase at a Chromosomal Locus (2008)

The ability to exogenously impose targeted epigenetic changes in the genome represents an attractive route for the simulation of genomic de novo epigenetic events characteristic of some diseases and for the study of their downstream effects and also provides a potential therapeutic approach for the heritable repression of selected genes. Here we demonstrate for the first time the ability of zinc finger peptides to deliver DNA cytosine methylation in vivo to a genomic integrated target promoter when expressed as fusions with a mutant prokaryotic DNA cytosine methyltransferase enzyme, thus mimicking cellular genomic de novo methylation events and allowing a direct analysis of the mechanics of de novo DNA methylation-mediated gene silencing at a genomic locus. We show that targeted methylation leads to gene silencing via the initiation of a repressive chromatin signature at the targeted genomic locus. This repression is maintained after the loss of targeted methyltransferase enzyme from the cell, confirming epigenetic maintenance purely through the action of cellular enzymes. The inherited DNA methylation pattern is restricted only to targeted sites, suggesting that the establishment of repressive chromatin structure does not drive further de novo DNA methylation in this system. As well as demonstrating the potential of these enzymes as tools for the exogenous, heritable control of cellular gene expression, this work also provides the most definitive confirmation to date for a transcriptionally repressive role for de novo DNA methylation in the cell and lends some weight to the hypothesis that the aberrant methylation associated with certain diseases may well be a cause rather than a consequence of transcriptional gene repression.
Quantitative Structure-Activity Relationships of Fungicidal <i>N</i>-Phenylformamidoximes (1992)

N-フェニルホルムアミドキシム類のベンセン環の置換基およびホルムアミドキシムのO-置換基の殺菌活性に対する影響を調べた. 殺菌活性はベンズイミダゾール系殺菌剤に耐性を示す Botrytis cinerea に対する活性を指標とした. ベンゼン環置換基についてはまずハロゲン, アルキル, アルコキシの様々な置換様式について in vivo の試験で活性を調べ, 3, 5-ジクロルフェニルの4位の置換基が活性に非常に大きな影響を与えることを把握した. そこで, この4位置換基について in vitro で活性を調べ, 構造活性相関を物理化学的パラメータを用いて重回帰分析により解析した. その結果, 置換基が直結した炭素の13C-NMRケミカルシフトを指標とする置換基の電子的性質および置換基のある一定方向の最大幅が, 活性の大きさの変化に有意に効果を及ぼすことがわかった. また, この置換基の性質は殺菌活性に対する影響ばかりでなく, ベンズイミダゾール系殺菌剤との負相関交差耐性という特性にもきわめて重大な影響を与えていた. ホルムアミドキシムのO-置換基についても, 同様に重回帰分析により定量的構造活性相関を解析したところ, 化合物の疎水性および置換基の最大幅 (B5) にそれぞれ最適値が存在することがわかった.
Length-weight relationship and condition factor of freshwater crab Barytelphusa gurini, (Decapoda, Brachyura). (2012)

The length-weight relationship and condition factor of Barytelphusagurini was studies. The exponent ‘b’, value for males 2.83 and for females it is2.03, and combined crabs is 2.35. Growth generally shows negative allometry in all crabs. The condition factor (K) for male is 0.000802, for female is 0.000669 and for combined sexes is 0.000214. The regression revealed high correlation andthe coefficient of determination (r2) for male is 97.8%, in female it is 98.6%, which is very close to 1, and in combined crabs it is 93.7%.
Multi-color still picture display with a 33-inch gas-discharge pulse memory panel. (1990)

33型カラー放電表示パネル (セルピッチ : 0.65mm, セル数 : 1024×800) にパルスメモリー駆動方式を適用してマルチカラーの静止画を表示した.駆動波形, 厚膜印刷プロセスの改善によりパネル全面にわたり安定なメモリー動作を得た.
Murine models of systemic lupus erythematosus: B and T cell responses to spliceosomal ribonucleoproteins in MRL/Faslpr and (NZB × NZW)F1 lupus mice (2001)

(NZB x NZW)F(1) and MRL/Fas(lpr) lupus mice present a similar phenotype with a spectrum of autoantibodies associated with very severe nephritis. It is thought, however, that in contrast to other lupus-prone mice such as MRL/Fas(lpr) mice, (NZB x NZW)F(1) mice do not generate autoantibodies to ribonucleoproteins (RNP) Sm/RNP. In this study, we demonstrate that contrary to previous reports, the autoimmune response directed against Sm/RNP antigens also occurs in NZB x NZW mice. CD4(+) T cells from unprimed 10-week-old NZB x NZW mice proliferate and secrete IL-2 in response to peptide 131-151 of the U1-70K protein, which is known to contain a T(h) epitope recognized by CD4(+) T cells from MRL/Fas(lpr) mice. Peptide 131-151, which was found to bind I-A(k) and I-E(k) class II MHC molecules, also bound both I-A(d) and I-E(d) molecules. This result led us to also re-evaluate longitudinally the anti-Sm/RNP antibody response in NZB x NZW mice. We found that 25-week-old mice do produce antibodies reacting with several small nuclear and heterogeneous nuclear (hn) RNP proteins, such as SmD1, U1-70K and hnRNP A2/B1 proteins. The fine specificity of these antibodies was studied with overlapping synthetic peptides. The same antigenically positive and negative peptides were characterized in MRL/Fas(lpr) and NZB x NZW mice in the three proteins. This new finding can help to understand the mechanisms involved in the development of the anti-Sm/RNP antibody response and, particularly, the role played by non-MHC genes in this autoimmune response.
Alopecia Areata (2012)

This review article synthesizes relevant information about hair-follicle biology and pathobiology and summarizes the clinical presentation and management of this common condition.
Activation of nicotinic acetylcholine receptors increases the rate of fusion of cultured human myoblasts. (1995)

1. Fusion of myogenic cells is important for muscle growth and repair. The aim of this study was to examine the possible involvement of nicotinic acetylcholine receptors (nAChR) in the fusion process of myoblasts derived from postnatal human satellite cells. 2. Acetylcholine-activated currents (ACh currents) were characterized in pure preparations of freshly isolated satellite cells, proliferating myoblasts, myoblasts triggered to fuse and myotubes, using whole-cell and single-channel voltage clamp recordings. Also, the effect of cholinergic agonists on myoblast fusion was tested. 3. No nAChR were observed in freshly isolated satellite cells. nAChR were first observed in proliferating myoblasts, but ACh current densities increased markedly only just before fusion. At that time most mononucleated myoblasts had ACh current densities similar to those of myotubes. ACh channels had similar properties at all stages of myoblast maturation. 4. The fraction of myoblasts that did not fuse under fusion-promoting conditions had no ACh current and thus resembled freshly isolated satellite cells. 5. The rate of myoblast fusion was increased by carbachol, an effect antagonized by alpha-bungarotoxin, curare and decamethonium, but not by atropine, indicating that nAChR were involved. Even though a prolonged exposure to carbachol led to desensitization, a residual ACh current persisted after several days of exposure to the nicotinic agonist. 6. Our observations suggest that nAChR play a role in myoblast fusion and that part of this role is mediated by the flow of ions through open ACh channels.
An efficient iris recognition system (2002)

Iris recognition, a relatively new biometric technology, has great advantages, such as variability, stability and security, and is most promising for high security environments. A new iris recognition algorithm is proposed in this paper, which adopts Independent Component Analysis (ICA) to extract iris texture feature and a competitive learning mechanism to recognize iris patterns. Experimental results show that the algorithm is efficient and adaptive to the environment, e.g. it works well even for blurred iris images, variable illumination, and interference of eyelids and eyelashes.
Mercaptosilane-Assisted Synthesis of Metal Clusters within Zeolites and Catalytic Consequences of Encapsulation (2010)

We report here a general synthetic strategy to encapsulate metal clusters within zeolites during their hydrothermal crystallization. Precursors to metal clusters are stabilized against their premature colloidal precipitation as hydroxides during zeolite crystallization using bifunctional (3-mercaptopropyl)trimethoxysilane ligands. Mercapto (-SH) groups in these ligands interact with cationic metal centers, while alkoxysilane moieties form covalent Si-O-Si or Si-O-Al linkages that promote zeolite nucleation around ligated metal precursors. These protocols led to the successful encapsulation of Pt, Pd, Ir, Rh, and Ag clusters within the NaA zeolite, for which small channel apertures (0.41 nm) preclude postsynthesis deposition of metal clusters. Sequential treatments in O(2) and H(2) formed small (approximately 1 nm) clusters with uniform diameter. Titration of exposed atoms with H(2) or O(2) gave metal dispersions that agree well with mean cluster sizes measured from electron microscopy and X-ray absorption spectroscopy, consistent with accessible cluster surfaces free of mercaptosilane residues. NaA micropore apertures restrict access to encapsulated clusters by reactants based on their molecular size. The ratio of the rates of hydrogenation of ethene and isobutene is much higher on clusters encapsulated within NaA than those dispersed on SiO(2), as also found for the relative rates of methanol and isobutanol oxidation. These data confirm the high encapsulation selectivity achieved by these synthetic protocols and the ability of NaA micropores to sieve reactants based on molecular size. Containment within small micropores also protects clusters against thermal sintering and prevents poisoning of active sites by organosulfur species, thus allowing alkene hydrogenation to persist even in the presence of thiophene. The bifunctional nature and remarkable specificity of the mercapto and alkoxysilane functions for metal and zeolite precursors, respectively, render these protocols extendable to diverse metal-zeolite systems useful as shape-selective catalysts in demanding chemical environments.
Stability of Diazoxide in Extemporaneously Compounded Oral Suspensions (2016)

The objective of this study was to evaluate the stability of diazoxide in extemporaneously compounded oral suspensions. Oral suspensions of diazoxide 10 mg/mL were prepared from either bulk drug or capsules dispersed in either Oral Mix or Oral Mix Sugar Free. These suspensions were stored at 5°C and 25°C/60%RH in bottles and oral syringes for a total of 90 days. At predetermined time intervals, suspensions were inspected for homogeneity, color or odor change; the pH was measured and the concentration of diazoxide was evaluated by ultraviolet detection using a stability-indicating high pressure liquid chromatography method. All preparations were demonstrated to be chemically stable for at least 90 days.
Embryonic stem cells from blastomeres maintaining embryo viability (2013)

This chapter reviews molecular mechanisms that control germline formation through a complex cascade of gene activation. In mammals, primordial germ cells (PGCs) are derived from the proximal epiblast during early embryogenesis. Interestingly, although both FRAGILIS and STELLA are differentially expressed in PGCs, neither appears to be essential for PGC specification. In general, migration of PGCs from primitive streak to genital ridges is believed to be governed by chemotactic cytokines, cell surface receptors, and cell adhesion factors. Until the colonization of the genital ridges, XX and XY PGCs are indistinguishable in terms of morphology and behavior. Mammalian male sex determination is initiated by sex-determining region Y (SRY) expression in XY genital ridges, which triggers Sertoli cell differentiation in supporting cell precursors. Germ-cell colonization of the gonads is followed by sex determination. Expression of sex-specific genes in somatic tissues initiates molecular events that lead to testis or ovary development.
Transmittance and Reflectance of Germicidal (λ2537) Energy (1946)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Matthew Luckiesh and A. H. Taylor, "Transmittance and Reflectance of Germicidal (λ2537) Energy," J. Opt. Soc. Am. 36, 227-234 (1946) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Dopaminergic deficit and the role of amisulpride in the treatment of mood disorders. (2002)

Amisulpride has now been investigated extensively in placebo controlled and in comparator controlled studies in patients suffering from dysthymia, both pure dysthymia and dysthymia with major depression. The clinical trial programme, which has shown the significant efficacy of amisulpride compared with placebo in three placebo controlled studies, has provided useful evidence of the value of a dopaminergic compound in the treatment of mood disorders. Amisulpride was superior to sertraline, an established treatment for depression and for dysthymia, on some measures and had a faster onset of effect. Retrospective analysis of the individual scale items showed that amisulpride had a broad range of effect on depressive symptoms with possible superiority on certain symptoms thought to be related to dopaminergic mechanisms. The body of studies supports the view that amisulpride is an effective and well-tolerated treatment for dysthymia and dysthymia with major depression.
Large off-axis epoxy paraboloids for millimetric telescopes and optical light collectors (1993)

Large, off-axis epoxy paraboloids with high surface accuracy (26 μm rms) were generated by spinning a bowl containing a long cure time, low viscosity epoxy. This note also describes procedures for generating and measuring meter-class surfaces.
Boot time optimization techniques for automotive rear view camera systems (2016)

Upon engaging the reverse gear in the car, very first information driver needs to know, whether is it really safe to take the reverse? Blind spots in car that result in rear view obstruction make this difficult. Advanced Driver Assistance Systems (ADAS) equip drivers with an application - Rear View Camera Systems (RVCS) to resolve this. There are simple RVCS which just show the rear view on the display or intelligent ones that run Object Detection (OD) algorithms on the captured video and flash warnings for drivers. In both cases, the boot time of the system is very crucial for safety as well as overall user experience, it is always annoying to wait for system to boot up. In autonomous cars the OD result is considered to make decisions, so that's even more safety critical. In short, the challenge is not only to boot within few milliseconds but get entire application working within short time. Heavy initialization time of subsystems involved make it tricky to achieve this at application level. This paper focuses on optimization techniques applied to similar RVCS. Boot time less than 500 milliseconds can be achieved using these techniques. These are also scalable to all fast boot ADAS solutions trying to achieve stringent boot time goals in order to ensure safety and improvise on this subtle user experience.
Remark on Shao et al.'s Bidirectional Proxy Re-signature Scheme in Indocrypt'07. (2009)

Recently, Shao et al. proposed two bidirectional proxy re-signature schemes Smb and Sid−mb [3]. In their paper, the authors gave security proofs to say that both of them are secure in their security model without random oracles. But, we found that the scheme Smb is miss leaded and its security proof is false. In this paper, we present an attack on Smb and improve it to be secure in their security model.
The 3rd generation of IBM's elastic interface on POWER6™ (2007)

This article consists of a collection of slides from the author's conference presentation on IBM's Power6, a third generation chip. Some of the specific topics discussed include: the special features of Power6; system and architecture design; circuit approaches; testability and hardware measurements; system design guidelines and rules; and new areas of system improvement.
Toxicology and Adverse Effects of Mineral Imbalance (1973)

(1973). Toxicology and Adverse Effects of Mineral Imbalance. Clinical Toxicology: Vol. 6, No. 3, pp. 459-485.
Tuning the Properties of Functional Pyrrolidinium Polymers by (Co)polymerization of Diallyldimethylammonium Ionic Liquids (2010)

The synthesis and polymerization of novel diallyldimethylammonium ionic liquid monomers is described. A free-radical polymerization follows a ring-closing cyclopolymerization mechanism similar to the one observed previously for diallyldimethylammonium halides that leads to pyrrolidinium functional polymers. As previously observed in other families of polymeric ionic liquids, their physico-chemical properties are seriously affected by the nature of the counter-anion. As an example, the thermal stability increases following the trend SCN(-) < ${\rm BF}_{4}^{ - }$ < ${\rm PF}_{6}^{ - }$ < bis(trifluoromethane)sulfonamide. Interestingly, this polymerization route may lead to the synthesis of a new family of random copolymers that have a similar poly(diallyldimethylammonium) backbone and a mixture of counter-anions determined by the comonomer selection.
Automatic adaptation of sensor-based robots (2007)

We present a framework for an adaptive system capable of automatically optimizing a given sensor-based program for an industrial robot to facilitate the development of fast and robust applications. We present a systematic overview of the layers of the robot controller in which a speed-up may be gained by incorporating adaptation techniques. We then measure the potential for optimization at a specific level to determine the improvement yielded with this optimization.
Présentation des auteurs (1996)

Jacques de Bandt est directeur de recherche au CNRS et enseigne à l’université de Nice-Sophia-Antipolis. Il est directeur de publication de la Revue d’économie industrielle et directeur de l’École d’été méditerranéenne d’économie industrielle. Paul Bouvier-Patron est docteur en sciences économiques (université Pierre-Mendès-France, Grenoble). Éric Brousseau est professeur à l’université de Nancy. Il est membre du Centre d’analyse théorique des organisations et des marchés (A...
Improved correlation technique for islanding detection of inverter based distributed generation (2008)

Islanding detection is one of the most important R&D topics in the area of distributed generation (DG) interconnection with utility grid. For many years, different anti-islanding protection methods were developed and proposed for inverter based distributed generation. However, most of these methods have a limit for detecting islanding when multiple DGs have to be connected with one distribution line. In this paper, we present theoritical and simulation analyses of the correlation method. The principle of the correlation technique is presented and the method was investigated for different operating conditions. The critical case-studies show that this method is effective for both single and multiple grid connected systems. In addition, to improve the effectiveness of the correlation technique, a user-defined M-sequence was used to calculate the correlation function.
Measurement of bow motion and bow force in violin playing (1986)

A simple piece of equipment which makes it possible to simultaneously register the motion of the violin bow and the downward force on the string (‘‘bow pressure’’) under normal playing conditions is described. Registrations of various bowing gestures in violin playing obtained with the equipment are presented and discussed.
Phase 1 dose de-escalation trial of the endogenous folate [6R]-5,10-methylene tetrahydrofolate in combination with fixed-dose pemetrexed as neoadjuvant therapy in patients with resectable rectal cancer (2015)

The results of this phase 1 study indicate that the estimated minimum tolerated dose of [6R]-MTHF was 100 mg/m(2) once weekly in combination with pemetrexed 500 mg/m(2). The low toxicity profile of [6R]-MTHF supports its further evaluation as a component of systemic chemotherapy in the management of colon and rectal cancer.
Mechanism for the large conductance modulation in electrolyte-gated thin gold films (2014)

Electrolyte gating using ionic liquid electrolytes has recently generated considerable interest as a method to achieve large carrier density modulations in a variety of materials. In noble metal thin films, electrolyte gating results in large changes in sheet resistance. The widely accepted mechanism for these changes is the formation of an electric double layer with a charged layer of ions in the liquid and accumulation or depletion of carriers in the thin film. We report here a different mechanism. In particular, we show using x-ray absorption near edge structure (XANES) that the previously reported large conductance modulation in gold films is due to reversible oxidation and reduction of the surface rather than the charging of an electric double layer. We show that the double layer capacitance accounts for less than 10% of the observed change in transport properties. These results represent a significant step towards understanding the mechanisms involved in electrolyte gating.
Dual antiplatelet therapy -- management in general practice. (2013)

Aspirin is still the mainstay of therapy in patients with acute coronary syndromes. The addition of clopidogrel, prasugrel or ticagrelor can reduce morbidity and mortality in selected patients. Patient factors including bleeding risk, renal function and time since coronary stent insertion must be reviewed before these agents are initiated and before making any changes to the medication regimen.
A coarse phonetic knowledge source for template independent large vocabulary word recognition (2005)

In this paper we present a template independent knowledge source (KS), that uses coarse phonetic information to substantially constrain the candidate vocabulary for use in word hypothesization with very large vocabularies. It consists of three parts: the segmenter that breaks a test utterance up into a sequence of coarse phonetic classes, the knowledge compiler that generates a reference dictionary containing the appropriate coarse phonetic representations for each word candidate and finally, a matching engine. Coarse phonetic classification is performed using linear discriminant analysis, more specifically perceptron classification. The knowledge compiler first generates a phonemic representation and segmental durations by rule from a list of word candidates (i.e., from text), and then derives coarse phonetic class segments. Matching is performed by a nonlinear time alignment algorithm based on dissimilarity scores between detected and lexical coarse class segments. The coarse phonetic KS was tested by compiling a word list of approximately 1500 words. Using only the coarse classes Silence, Plosive, Fricative, Vocalic, Front Vowel, Back Vowel, Nasal and R, a vocabulary reduction to 5% of the original vocabulary is achieved at lower than 5% error rate for three different speakers.
Application of grammar-based codes for lossless compression of digital mammograms (2006)

A newly developed grammar-based lossless source coding theory and its implementation was proposed in 1999 and 2000, respectively, by Yang and Kieffer. The code first transforms the original data sequence into an irreducible context-free grammar, which is then compressed using arithmetic coding. In the study of grammar-based coding for mammography applications, we encountered two issues: processing time and limited number of single-character grammar G variables. For the first issue, we discover a feature that can simplify the matching subsequence search in the irreducible grammar transform process. Using this discovery, an extended grammar code technique is proposed and the processing time of the grammar code can be significantly reduced. For the second issue, we propose to use double-character symbols to increase the number of grammar variables. Under the condition that all the G variables have the same probability of being used, our analysis shows that the double- and single-character approaches have the same compression rates. By using the methods proposed, we show that the grammar code can outperform three other schemes: Lempel-Ziv-Welch (LZW), arithmetic, and Huffman on compression ratio, and has similar error tolerance capabilities as LZW coding under similar circumstances.