gebhart/patrepeval huggingface dataset:
Polarization imaging for industrial inspection (2008)

This paper aims at reviewing the recent published works dealing with industrial applications which rely on polarization imaging. A general introduction presents the basics of polarimetry and then 2D and 3D machine vision application are presented as well as the latest evolution in term of high speed polarimetric imaging.
Supercapacitor Energy Storage for Magnetic Resonance Imaging Systems (2013)

Magnetic resonance imaging (MRI) involves very short pulses of very high current. Substantial savings in the high cost of MRI installations may be realized by employing suitable electrical energy storage, for which supercapacitors are strong candidates in view of high specific power and long cycle life. A key question is whether the well-known capacitance degradation with increased frequency is compatible with the complex and highly variable duty cycles of various MRI sequences. Compatibility of the supercapacitor voltage range with the MRI system must also be considered. We present a detailed analysis of power duty profiles in MRI, using actual imaging sequences, that has not been reported previously. We also propose and validate a simplified supercapacitor model that can accurately simulate its performance in the MRI system, involving pulses that are several orders of magnitude shorter than those considered previously. Results of equivalent experiments involving lithium-ion iron phosphate ( LiFePO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> ) batteries are also reported. Finally, we present a detailed analysis of the overall energy storage performance in a realistic neurological examination. The study is based on a specific system of our own design, and we fully disclose its relevant parameters, so that the results would be of direct practical value to the wider community, including developers of MRI.
Components of the yeast spindle and spindle pole body. (1990)

Yeast spindle pole bodies (SPBs) with attached nuclear microtubles were enriched approximately 600-fold from yeast cell extracts. 14 mAbs prepared against this enriched SPB fraction define at least three components of the SPB and spindle. Immunofluorescent staining of yeast cells showed that throughout the cell cycle two of the components (110 and 90 kD) were localized exclusively to the SPB region, and the other (80 kD) was localized both to the SPB region and to particulate dots in short spindles. Immunoelectron microscopy confirmed and extended most of these findings. Thus the 110-kD component was localized to a layer in the SPB just to the nuclear side of the plane of the inner nuclear membrane. The 90-kD component was localized in a layer across the cytoplasmic face of intact SPBs, and, in SPBs where nuclear microtubules were removed by extraction with DEAE-dextran, the 90-kD component was also found in an inner nuclear layer close to where spindle microtubules emerge. In intact SPBs with attached nuclear microtubules the anit-80-kD mAb labels microtubules, particularly those close to the SPB. These results begin to provide a preliminary molecular map of the SPB and should also enable the corresponding genes to be isolated.
DNA Zipper-Based Tweezers (2011)

Here we report the design and development of DNA zippers and tweezers. Essentially a zipper system consists of a normal strand (N), a weak strand (W), and an opening strand (O). N strand is made up of normal DNA bases, while W is engineered to have inosine substituting for guanine. By altering the number and order of inosine, W is engineered to provide less than natural bonding affinities to N in forming the [N:W] helix. When O is introduced (a natural complement of N), it competitively displaces W from [N:W] and forms [N:O]. This principle is incorporated in the development of a molecular device that can perform the functions of tweezers (sense, hold, and release). Tweezers were constructed by holding N and W together using a hinge at one end. Thus, when the tweezers open, N and W remain in the same vicinity. This allows the tweezers to cycle among open and close positions by their opening and closing strands. Control over their opening and closing kinetics is demonstrated. In contrast to the previously reported DNA tweezers, the zipper mechanism makes it possible to operate them with opening strands that do not contain single-stranded DNA overhangs. Our approach yields a robust, compact, and regenerative tweezer system that could potentially be integrated into complex nanomachines.
How Financial Engineering Can Advance Corporate Strategy (1996)

Practitioners of a new technical specialty--financial engineering--can help senior managers achieve their companies' objectives. Financial engineering can not only reduce the cost of existing activities but also make possible the development of new products, services, and markets. Peter Tufano presents five case studies that illustrate innovative applications of financial engineering and helps managers determine when such techniques are appropriate. The cases highlight five companies that faced different challenges: Enron Capital & Trade Resources, Tennessee Valley Authority, Rhone-Poulenc, Cemex, and MW Petroleum Corporation. All of them found that traditional approaches were inadequate--the costs or the risks seemed too high. A nontraditional solution, however, required that the companies commit to bearing risks that their customers, employees, or counterparties sought to shed. Without a means of structuring, valuing, and mitigating those risks, the initiatives that the companies pursued seemed doomed to failure. In the end, the innovative approach was made possible by the concepts, tools, and markets of financial engineers. The cases show that collaboration between managers and financial engineers can help create a competitive edge by differentiating products through enhanced price and delivery options, by increasing production capacity with flexible alternatives to capital investment, by changing the risk characteristics of holding stock, or by keeping strategic mergers on track through the creation of win-win situations.
The Journal of Clinical Investigation in the time of COVID-19 (2021)

In this editorial, we describe the experience of the JCI editors during the COVID-19 pandemic. Our goal is to share how we operated during the pandemic, recount how the JCI contributed to the response, highlight some of the major papers we published on SARS-CoV-2 and COVID-19, and impart our insights in the hope that these are helpful to journal editors that may need to deal with similar types of crises in the future.
Ultralightweight Mutual Authentication RFID Protocol for Blockchain Enabled Supply Chains (2019)

Previous research studies mostly focused on enhancing the security of radio frequency identification (RFID) protocols for various RFID applications that rely on a centralized database. However, blockchain technology is quickly emerging as a novel distributed and decentralized alternative that provides higher data protection, reliability, immutability, transparency, and lower management costs compared with a conventional centralized database. These properties make it extremely suitable for integration in a supply chain management system. In order to successfully fuse RFID and blockchain technologies together, a secure method of communication is required between the RFID tagged goods and the blockchain nodes. Therefore, this paper proposes a robust ultra-lightweight mutual authentication RFID protocol that works together with a decentralized database to create a secure blockchain-enabled supply chain management system. Detailed security analysis is performed to prove that the proposed protocol is secure from key disclosure, replay, man-in-the-middle, de-synchronization, and tracking attacks. In addition to that, a formal analysis is conducted using Gong, Needham, and Yahalom logic and automated validation of internet security protocols and applications tool to verify the security of the proposed protocol. The protocol is proven to be efficient with respect to storage, computational, and communication costs. In addition to that, a further step is taken to ensure the robustness of the protocol by analyzing the probability of data collision written to the blockchain.
NAIMA: target amplification strategy allowing quantitative on-chip detection of GMOs (2008)

We have developed a novel multiplex quantitative DNA-based target amplification method suitable for sensitive, specific and quantitative detection on microarray. This new method named NASBA Implemented Microarray Analysis (NAIMA) was applied to GMO detection in food and feed, but its application can be extended to all fields of biology requiring simultaneous detection of low copy number DNA targets. In a first step, the use of tailed primers allows the multiplex synthesis of template DNAs in a primer extension reaction. A second step of the procedure consists of transcription-based amplification using universal primers. The cRNA product is further on directly ligated to fluorescent dyes labelled 3DNA dendrimers allowing signal amplification and hybridized without further purification on an oligonucleotide probe-based microarray for multiplex detection. Two triplex systems have been applied to test maize samples containing several transgenic lines, and NAIMA has shown to be sensitive down to two target copies and to provide quantitative data on the transgenic contents in a range of 0.1-25%. Performances of NAIMA are comparable to singleplex quantitative real-time PCR. In addition, NAIMA amplification is faster since 20 min are sufficient to achieve full amplification.
Curcumin Prevents Formation of Polyglutamine Aggregates by Inhibiting Vps36, a Component of the ESCRT-II Complex (2012)

Small molecules with antioxidative properties have been implicated in amyloid disorders. Curcumin is the active ingredient present in turmeric and known for several biological and medicinal effects. Adequate evidence substantiates the importance of curcumin in Alzheimer's disease and recent evidence suggests its role in Prion and Parkinson's disease. However, contradictory effects have been suggested for Huntington's disease. This difference provided a compelling reason to investigate the effect of curcumin on glutamine-rich (Q-rich) and non-glutamine-rich (non Q-rich) amyloid aggregates in the well established yeast model system. Curcumin significantly inhibited the formation of htt72Q-GFP (a Q-rich) and Het-s-GFP (a non Q-rich) aggregates in yeast. We show that curcumin prevents htt72Q-GFP aggregation by down regulating Vps36, a component of the ESCRT-II (Endosomal sorting complex required for transport). Moreover, curcumin disrupted the htt72Q-GFP aggregates that were pre-formed in yeast and cured the yeast prion, [PSI(+)].
Development and application of diazirines in biological and synthetic macromolecular systems (2005)

Many different reagents and methodologies have been utilised for the modification of synthetic and biological macromolecular systems. In addition, an area of intense research at present is the construction of hybrid biosynthetic polymers, comprised of biologically active species immobilised or complexed with synthetic polymers. One of the most useful and widely applicable techniques available for functionalisation of macromolecular systems involves indiscriminate carbene insertion processes. The highly reactive and non-specific nature of carbenes has enabled a multitude of macromolecular structures to be functionalised without the need for specialised reagents or additives. The use ofdiazirines as stable carbene precursors has increased dramatically over the past twenty years and these reagents are fast becoming the most popular photophors for photoaffinity labelling and biological applications in which covalent modification of macromolecular structures is the basis to understanding structure-activity relationships. This review reports the synthesis and application of a diverse range of diazirines in macromolecular systems.
Arousal of Cancer-Associated Stroma: Overexpression of Palladin Activates Fibroblasts to Promote Tumor Invasion (2012)

Overall, palladin expression can impart myofibroblast properties, in turn promoting the invasive potential of these peri-tumoral cells with invadopodia-driven degradation of extracellular matrix. Palladin expression in fibroblasts can be triggered by k-ras expression in adjacent epithelial cells. This data supports a model whereby palladin-activated fibroblasts facilitate stromal-dependent metastasis and outgrowth of tumorigenic epithelium.
Employing ∼100% Excitons in OLEDs by Utilizing a Fluorescent Molecule with Hybridized Local and Charge‐Transfer Excited State (2013)

In principle, the ratio (Φ) of the maximum quantum efficiencies for electroluminescence (EL) to photoluminescence (PL) can be expected to approach unity, if the exciton (bound electron–hole pair) generated from the recombination of injected electrons and holes in OLEDs has a sufficiently weak binding energy. However, seldom are examples of Φ > 25% reported in OLEDs because of the strongly bound excitons for most organic semiconductors in nature. Here, a twisting donor–acceptor triphenylamine‐thiadiazol molecule (TPA‐NZP) exhibits fluorescent emission through a hybridized local and charge‐transfer excited state (HLCT), which is demonstrated from both fluorescent solvatochromic experiment and quantum chemical calculations. The HLCT state possesses two combined and compatible characteristics: a large transition moment from a local excited (LE) state and a weakly bound exciton from a charge transfer (CT) state. The former contributes to a high‐efficiency radiation of fluorescence, while the latter is responsible for the generation of a high fraction of singlet excitons. Using TPA‐NZP as the light‐emitting layer in an OLED, high Φ values of 93% (at low brightness) and 50% (at high brightness) are achieved, reflecting sufficient employment of the excitons in the OLED. Characterization of the EL device shows a saturated deep‐red emission with CIE coordinates of (0.67, 0.32), accompanied by a rather excellent performance with a maximum luminance of 4574 cd m −2 and a maximum external quantum efficiency (η ext ) of ∼2.8%. The HLCT state is a new way to realize high‐efficiency of EL devices.
A bus controlled clock generator IC (for TV front end) (1991)

The author describes a line-locked clock generation circuit for digital video processing systems with a digital line-PLL (phase-locked loop) and a digital/analog clock-PLL. A virtual frequency twice that of a crystal is used.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Superconducting cavities for accelerators (1998)

Superconducting cavities have been in operation in accelerators for 25 years. In the last decade many installations in storage rings and linacs have been completed. Meanwhile, nearly 1 km of active cavity length is in operation in accelerators. Large-scale applications of superconducting radiofrequency systems are planned for future linear colliders and proton linacs.
Low-loss tuning circuits for frequency-tunable small resonant antennas (2003)

Minimization of power loss in the tuning circuits of frequency-tunable small resonant antennas, such as microstrip patches, is studied. First, the frequency shift and the associated power loss in certain tuning circuits are theoretically calculated based on approximate circuit models of fairly narrowband resonant antennas. By investigating the ratio of frequency shift and loss, an optimal configuration for the tuning circuit can be determined. The theoretical results can be used to provide optimal starting values and design curves that facilitate the final design with a full-wave electromagnetic simulator. To support the theory, a design procedure is demonstrated with two example antenna structures, for which both simulated and measured results are presented.
Chirped Laser Dispersion Spectroscopy for Remote Open-Path Trace-Gas Sensing (2012)

In this paper we present a prototype instrument for remote open-path detection of nitrous oxide. The sensor is based on a 4.53 μm quantum cascade laser and uses the chirped laser dispersion spectroscopy (CLaDS) technique for molecular concentration measurements. To the best of our knowledge this is the first demonstration of open-path laser-based trace-gas detection using a molecular dispersion measurement. The prototype sensor achieves a detection limit down to the single-ppbv level and exhibits excellent stability and robustness. The instrument characterization, field deployment performance, and the advantages of applying dispersion sensing to sensitive trace-gas detection in a remote open-path configuration are presented.
Offline Arabic handwriting recognition: a survey (2006)

The automatic recognition of text on scanned images has enabled many applications such as searching for words in large volumes of documents, automatic sorting of postal mail, and convenient editing of previously printed documents. The domain of handwriting in the Arabic script presents unique technical challenges and has been addressed more recently than other domains. Many different methods have been proposed and applied to various types of images. This paper provides a comprehensive review of these methods. It is the first survey to focus on Arabic handwriting recognition and the first Arabic character recognition survey to provide recognition rates and descriptions of test data for the approaches discussed. It includes background on the field, discussion of the methods, and future research directions.
UMTS mobility management (1993)

The characteristics of first, second and third generation mobile communication systems are first described. The state of standardisation of the universal mobile telecommunication system (UMTS) is then outlined and the system concept is introduced. A mobility management platform which will provide uniform access to mobility functions for every user or network entity independent of the actual location of the requested function in the network is described. The mobility management platform is based on the intelligent network concept. Mobility management aims to share the processing load in the distributed UMTS environment.
Biophysical mechanisms responsible for pulsed low-level laser excitation of neural tissue (2006)

<b>Background/Objective:</b> The traditional method of stimulating neural activity has been based on electrical methods and remains the gold standard to date despite inherent limitations. We have previously shown a new paradigm to in vivo neural activation based on pulsed infrared light, which provides a contact-free, spatially selective, artifact-free method without incurring tissue damage that may have significant advantages over electrical stimulation in a variety of diagnostic and therapeutic applications. The goal of this study was to investigate the physical mechanism of this phenomenon, which we propose is a photo-thermal effect from transient tissue temperature changes resulting in direct or indirect activation of transmembrane ion channels causing propagation of the action potential. <b>Methods:</b> Rat sciatic nerve preparation was stimulated in vivo with the Holmium:YAG laser (2.12μm), Free Electron Laser (2.1μm), Alexandrite laser (690nm), and the prototype for a solid state commercial laser nerve stimulator built by Aculight (1.87μm) to determine contributions of photobiological responses from laser tissue interactions, including temperature, pressure, electric field, and photochemistry, underlying the biophysical mechanism of stimulation. Single point temperature measurements were made with a microthermocouple adjacent to the excitation site, while an infrared camera was used for 2-D radiometry of the irradiated surface. Displacement from laser-induced pressure waves or thermoelastic expansion was measured using a PS-OCT system. <b>Results:</b> Results exclude a direct photochemical, electric field, or pressure wave effect as the mechanism of optical stimulation. Measurements show relative small contributions from thermoelastic expansion (300 nm) with the laser parameters used for nerve stimulation. The maximum change in tissue temperature is about 9°C (average increase of 3.66 °C) at stimulation threshold radiant exposures. <b>Conclusion:</b> Neural activation with pulsed laser-light occurs by a transient thermally induced mechanism. Future experiments will reveal if this effect is through direct membrane interaction or facilitated through an indirect effect leading to membrane depolarization.
Non-Systemic Drugs: A Critical Review (2012)

Non-systemic drugs act within the intestinal lumen without reaching the systemic circulation. The first generation included polymeric resins that sequester phosphate ions, potassium ions, or bile acids for the treatment of electrolyte imbalances or hypercholesteremia. The field has evolved towards non-absorbable small molecules or peptides targeting luminal enzymes or transporters for the treatment of mineral metabolism disorders, diabetes, gastrointestinal (GI) disorders, and enteric infections. From a drug design and development perspective, non-systemic agents offer novel opportunities to address unmet medical needs while minimizing toxicity risks, but also present new challenges, including developing a better understanding and control of non-transcellular leakage pathways into the systemic circulation. The pharmacokinetic-pharmacodynamic relationship of drugs acting in the GI tract can be complex due to the variability of intestinal transit, interaction with chyme, and the complex environment of the surface epithelia. We review the main classes of nonabsorbable agents at various stages of development, and their therapeutic potential and limitations. The rapid progress in the identification of intestinal receptors and transporters, their functional characterization and role in metabolic and inflammatory disorders, will undoubtedly renew interest in the development of novel, safe, non-systemic therapeutics.
Characteristics of InGaN quantum wells light-emitting diodes with thin AlGaInN barrier layers (2012)

The characteristics of InGaN quantum wells light-emitting diodes with thin large bandgap AlGaInN barriers were analyzed with taking into account the carrier transport effect, which resulted in efficiency-droop suppression.
Bodyguards and assassins: Bcl‐2 family proteins and apoptosis control in chronic lymphocytic leukaemia (2005)

Chronic lymphocytic leukaemia (CLL) is the most common B-cell malignancy in the Western world and exists as subtypes with very different clinical courses. CLL is generally described as a disease of failed apoptosis. Apoptosis resistance may stem from a combination of microenvironmental survival signals as well as from intrinsic alterations in the apoptotic machinery within the CLL cell. The molecular mechanism involved in controlling apoptosis in CLL is complex and is influenced by many factors, including Bcl-2 family proteins, which are critical regulators of cell death. Here we review the significance of apoptosis dysregulation in CLL, focusing on the role of Bcl-2 and related Bcl-2 family proteins, such as Bax and Mcl-1. The differential properties of the newly described subsets of CLL are also highlighted.