gebhart/patrepeval huggingface dataset:
Comparison of Endocervical Curettage and Endocervical Brushing (2000)

In Brief Objective To compare endocervical brushing with endocervical curettage with respect to diagnostic yield by histology and patient discomfort. Methods Nonpregnant women referred for colposcopy because of abnormal Papanicolaou test results were randomized to endocervical sampling with either a metal curette (endocervical curettage [ECC]) or an endocervical brush. Extensive endocervical canal brushing was performed. All samples were submitted for histologic study. Results were evaluated against the histologic findings in electroconization specimens in a masked fashion. Pain scores were recorded using Melzack's Present Pain Intensity Scale. Results During the study period, 315 patients were randomized to the techniques: 157 to ECC and 158 to endocervical brushing. Of the 315 patients, 147 also underwent electroconization. Overall false-positive rates were 28.6% for endocervical brushing and 30.8% for ECC. False positives were due to contamination of the endocervical sample by lesional epithelium near the external os. The proportion of scanty specimens obtained by endocervical brushing (7.6%) was higher than that obtained by ECC (2.5%) (P = .041). One sample obtained by brushing was insufficient for diagnosis; none obtained by ECC were insufficient. There were no statistically significant differences in the median pain scores between the two groups. Conclusion The techniques were similar in terms of diagnostic yield and patient discomfort. Endocervical brushing had lower false-positive rates than those reported in the literature for cytologic analysis. Although ECC remains the method of choice for evaluation of the endocervical canal, brushing is an acceptable alternative. Endocervical brushing for histologic evaluation of the endocervical canal yields diagnostic results and causes patient discomfort similar to those associated with conventional endocervical curettage.
Implementation of ECC/ECDSA cryptography algorithms based on Java card (2003)

This paper describes the implementations and test results of elliptic curve cryptography (ECC) and elliptic curve digital signature algorithm (ECDSA) algorithms based on Java card. A 163-bit ECC guarantees as secure as the 1024-bit Rivest-Shamir-Adleman (RSA) public key algorithm, which has been frequently used until now. According to our test results, the 163-bit ECC processing time is about five times faster compared with the 1024-bit RSA, and the amount of resource usages of ECC is smaller than RSA. Therefore, ECC is more appropriate for use on secure devices such as smart cards and wireless devices with constrained computational power consumption and memory resources.
Estrogen receptor binding to a DNA response element in vitro is not dependent upon estradiol (1990)

Gel shift assays were employed to distinguish between the contribution of 17 beta-estradiol (E2) and a short heating step to the ability of the rat uterine cytosolic estrogen receptor (ER) to bind to the estrogen response element (ERE) from the vitellogenin A2 gene (vitERE). Despite the popularity of models in which the ER is a ligand-activated DNA-binding protein, these studies find that estrogen does not significantly contribute to receptor-DNA complex formation. An avidin-biotin complex with DNA (ABCD) assay was utilized to obtain quantitative measurement of the affinities of the ER for the vitERE and a mutant sequence. Scatchard analysis gave a dissociation constant of 390 +/- 40 pM for the E2-occupied, heated ER to the vitERE. The data fit a one-site model and evidence for cooperatively was not observed. A dissociation constant of 450 +/- 170 pM was obtained for the unoccupied, heated ER, leading to the conclusion that estrogen was not necessary for specific binding to DNA. The percentage of ER capable of binding vitERE varied with each cytosol preparation, ranging from 60 to 100% and estrogen did not appear to affect this variation. Competition against the vitERE with a 2-bp mutant sequence showed a 250-fold lower relative binding affinity of the receptor for the mutant over the vitERE sequence. This ability of the ER to discriminate between target and nonspecific DNA sequences was also not dependent on the presence of estrogen.
Pharmacokinetics of Absorption and Elimination of Doxycycline in Man (1967)

Research Articles| May 18 2009 Pharmacokinetics of Absorption and Elimination of Doxycycline in Man Subject Area: Further Areas , Oncology , Pharmacology Milo Gibaldi Milo Gibaldi Department of Pharmaceutics, School of Pharmacy State University of New York at Buffalo, Buffalo, N.Y. Search for other works by this author on: This Site PubMed Google Scholar Chemotherapia (1967) 12 (5): 265–271. https://doi.org/10.1159/000220508 Article history Published Online: May 18 2009 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Milo Gibaldi; Pharmacokinetics of Absorption and Elimination of Doxycycline in Man. Chemotherapia 1 May 1967; 12 (5): 265–271. https://doi.org/10.1159/000220508 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsChemotherapia Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1967Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
A high reliability triple metal process for high performance application specific circuits (2002)

A triple metal process for high performance, high reliability application specific CMOS circuits is described. Key features of this process are identical pitches for all three levels of metal, layered metal for high electromigration resistance of interconnects and vias, planarised dielectrics, and very good hot carrier reliability of submicron MOS devices.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
SAMD9 and SAMD9L in inherited predisposition to ataxia, pancytopenia, and myeloid malignancies (2018)

Germline mutations in the SAMD9 and SAMD9L genes, located in tandem on chromosome 7, are associated with a clinical spectrum of disorders including the MIRAGE syndrome, ataxia-pancytopenia syndrome and myelodysplasia and leukemia syndrome with monosomy 7 syndrome. Germline gain-of-function mutations increase SAMD9 or SAMD9L's normal antiproliferative effect. This causes pancytopenia and generally restricted growth and/or specific organ hypoplasia in non-hematopoietic tissues. In blood cells, additional somatic aberrations that reverse the germline mutation's effect, and give rise to the clonal expansion of cells with reduced or no antiproliferative effect of SAMD9 or SAMD9L include complete or partial chromosome 7 loss or loss-of-function mutations in SAMD9 or SAMD9L. Furthermore, the complete or partial loss of chromosome 7q may cause myelodysplastic syndrome in these patients. SAMD9 mutations appear to associate with a more severe disease phenotype, including intrauterine growth restriction, developmental delay and hypoplasia of adrenal glands, testes, ovaries or thymus, and most reported patients died in infancy or early childhood due to infections, anemia and/or hemorrhages. SAMD9L mutations have been reported in a few families with balance problems and nystagmus due to cerebellar atrophy, and may lead to similar hematological disease as seen in SAMD9 mutation carriers, from early childhood to adult years. We review the clinical features of these syndromes, discuss the underlying biology, and interpret the genetic findings in some of the affected family members. We provide expert-based recommendations regarding diagnosis, follow-up, and treatment of mutation carriers.
Light-Adaptive Supramolecular Nacre-Mimetic Nanocomposites (2016)

Nature provides design paradigms for adaptive, self-healing, and synergistic high-performance structural materials. Nacre's brick-and-mortar architecture is renowned for combining stiffness, toughness, strength, and lightweightness. Although elaborate approaches exist to mimic its static structure and performance, and to incorporate functionalities for the engineering world, there is a profound gap in addressing adaptable mechanical properties, particularly using remote, quick, and spatiotemporal triggers. Here, we demonstrate a generic approach to control the mechanical properties of nacre-inspired nanocomposites by designing a photothermal energy cascade using colloidal graphene as light-harvesting unit and coupling it to molecularly designed, thermoreversible, supramolecular bonds in the nanoconfined soft phase of polymer/nanoclay nacre-mimetics. The light intensity leads to adaptive steady-states balancing energy uptake and dissipation. It programs the mechanical properties and switches the materials from high stiffness/strength to higher toughness within seconds under spatiotemporal control. We envisage possibilities beyond mechanical materials, for example, light-controlled (re)shaping or actuation in highly reinforced nanocomposites.
Flavor Chemistry of Animal Foods (1978)

For a terrestrial animal, flavor may be defined as the composite sensation resulting from placing something in the mouth. Therefore, flavor may include taste, olfactory, vomeronasal, trigeminal and other chemical sense inputs as well as tactile, temperature and proprioceptive cues. Thus, the subjective sensation we call flavor is the result of interactions of a complex of receptors. The bulk of experimental work in this field has focussed upon one class of receptors and associated CNS processes, the taste system. There are powerful arguments that the taste system is a uniquely important component in regulating flavor perception and food intake (e.g., 1,2), but other sensory components significantly influence flavor perception (e.g., 3, 4).
Removal of Molybdate and Arsenate from Aqueous Solutions by Flotation (1996)

Abstract Ion flotation and adsorbing colloid flotation have been studied in this paper for the effective removal of molybdenum(VI) and arsenic(V) from dilute aqueous solutions. These different flotation methods were also compared. Ion flotation using a cationic surfactant (dodecylamine) as collector, as well as adsorbing colloid flotation using ferric hydroxide as coprecipitant (or sorbent) and an anionic surfactant (sodium dodecyl sulfate) as collector were examined. Laboratory-scale experiments were conducted in order to assess the effects of the following parameters on the efficiency of the process: pH value, dosages of chemical reagents, initial concentrations of arsenic and molybdenum, and the presence of foreign anions, such as Cl- and SO2 4 -. In practical applications, ion flotation or adsorbing colloid flotation may be selected according to the concentration of arsenic, molybdenum, and also the initial [Mo]/[As] molar ratios in solution.
Improving the Classical Geophone Sensor Element by Digital Correction (2005)

Geophones are highly sensitive motion transducers that have been used by seismologists and geophysicists for decades. The conventional geophone&apos;s ratio of cost to performance, including noise, linearity and dynamic range is unmatched by advanced modern accelerometers. However, the problem of this sensor is that it measures velocity, and that the linear frequency range is limited to frequencies above the natural frequency, typically at 4-12 Hz. It is shown in this paper how the sensor signal can be digitally linearized 2 decades below the natural frequency obtaining a sensor that allows the user to measure displacement, velocity or acceleration with high sensitivity and large dynamic range.
A Completely Single-Mode and Single-Polarization Vertical-Cavity Surface Emitting Lasers Grown on GaAs (311)B Substrate (1998)

We realized a completely single-mode and single-polarization 0.98 µm InGaAs/GaAs vertical-cavity surface emitting laser (VCSEL) grown on a GaAs (311) B substrate. The device operates in a single transverse, longitudinal mode and polarization state in the entire tested current range. An oxide confinement structure with a nearly square oxide aperture of 2.5 µm×3.0 µm was formed for transverse mode control. We obtained a side mode suppression ratio of over 35 dB and a polarization mode suppression ratio of over 25 dB between the [233] and the [011] axis modes in the entire driving range. The threshold voltage and electrical specific resistance are as low as 1.5 V and 1.1×10 -4 Ω·cm -2 , respectively. One of the tested devices shows a record low threshold current of 230 µA for non-(100) substrates.
Jogging with a Quadcopter (2015)

Jogging is a popular exertion activity. The abundance of jogging apps suggests to us that joggers can appreciate the opportunity for technology to support the jogging experience. We want to take this investigation a step further by exploring if, and how, robotic systems can support the jogging experience. We designed and built a flying robotic system, a quadcopter, as a jogging companion and studied its use with 13 individual joggers. By analyzing their experiences, we derived three design dimensions that describe a design space for flying robotic jogging companions: Perceived Control, Focus and Bodily Interaction. Additionally, we articulate a series of design tactics, described by these dimensions, to guide the design of future systems. With this work we hope to inspire and guide designers interested in creating robotic systems to support exertion experiences.
Calponin phosphorylation <i>in vitro</i> and in intact muscle (1993)

Calponin, a thin-filament-associated protein implicated in the regulation of smooth-muscle contraction, is phosphorylated in vitro by protein kinase C and Ca2+/calmodulin-dependent protein kinase II [Winder and Walsh (1990) J. Biol. Chem. 265, 10148-10155] and dephosphorylated by a type 2A protein phosphatase [Winder, Pato and Walsh (1992) Biochem. J. 286, 197-203]. Unphosphorylated calponin binds to actin and inhibits the actin-activated myosin MgATPase; these properties are lost on phosphorylation. Although both serine and threonine residues in calponin are phosphorylated, the major site of phosphorylation by either kinase is Ser-175. Calponin also undergoes phosphorylation when bound to actin in synthetic thin filaments, in a reconstituted actomyosin system, in washed myofibrils and in tissue extracts; this results in dissociation of calponin from actin. Tryptic phosphopeptide mapping indicates that the same sites are phosphorylated in the bound as in the isolated protein. Toad stomach calponin exists in at least three isoforms which differ in charge but exhibit the same molecular mass on SDS/PAGE. In a toad stomach extract, all three isoforms are phosphorylated by protein kinase C or Ca2+/calmodulin-dependent protein kinase II as shown by two-dimensional gel electrophoresis (non-equilibrium pH-gradient gel electrophoresis and SDS/PAGE). Calponin phosphorylation also occurs in intact toad stomach smooth-muscle strips metabolically labelled with 32Pi and stimulated to contract with carbachol. These results support the hypothesis that calponin may be regulated in vivo by phosphorylation-dephosphorylation.
Caractérisation de la stabilité d'un élément piézoélectrique du type PZT sous compression uniaxiale rapide (1983)

Le présent article concerne la caractérisation de céramiques piézoélectriques au zirconotitanate de plomb destinées à l'allumage réversible par impact. Les mesures d'énergie complétées par des tests de stabilité sous 400 impacts de durée différente font apparaître les paramètres essentiels suivants : la stabilité est une fonction décroissante de cette durée ; la qualité du matériau dépend de l'état lacunaire et de l'équilibre électrique de sa composition ainsi que du rapport des concentrations en zirconium et en titane.
Thermally stable polymers based on acetylene‐terminated adamantanes (1992)

Abstract 1,3‐Diethynyl‐5,7‐dimethyladamantane, 1,3‐diethynyl‐5‐phenyladamantane, 1,3,5‐triethynyladamantane, and 3,3′‐diethynyl‐1,1′‐biadamantane, were synthesized and polymerized thermally at 210°C. The thermoset resins obtained were post‐cured at 300°C for 16 h to give materials that exhibited onsets of degradation (TGA) in air at 460–477°C and in helium at 460–485°C. The fully cured materials did not exhibit any detectable DSC transitions between 25 and 400°C. An attempt to thermally polymerize 1‐ethynyl‐3‐phenyladamantane was unsuccessful. © 1992 John Wiley & Sons, Inc.
Negative regulation of TLR9-mediated IFN-α induction by a small-molecule, synthetic TLR7 ligand (2007)

Toll-like receptors (TLRs) are a family of molecules that function as sensors for the detection of foreign pathogens through the recognition of nonvariable microbial motifs. Although numerous studies have focused on singular TLRs, less attention has been focused on how simultaneous signaling of multiple TLRs may result in counter-regulation of the effects of each. Here, we examine the counter-regulation that occurs during simultaneous stimulation of TLR7 and TLR9 on human plasmacytoid dendritic cells (PDCs) and B cells. Interestingly, we observed that the capacity for potent IFN-alpha-induction by TLR9 ligands like CpG-C and CpG-A is markedly reduced by concurrent small molecule TLR7 stimulation. However, this inhibition is specific to particular CpG motif-containing immunostimulatory sequence (ISS) functions such as IFN-alpha induction and BDCA-2 down-regulation. Other ISS activities such as PDC expression of CD80/CD86, secretion of IL-6, and B cell proliferation are not altered by the presence of TLR7 ligands (TLR7Ls). In concordance with the ability of TLR7Ls to decrease IFN-alpha secretion induced by ISS, we also find that the expression of interferon regulatory factor-7 (IRF-7), a transcriptional factor critical for IFN-alpha expression, is reduced. Furthermore, down-regulation of TLR9 mRNA expression is accelerated after TLR7 stimulation. These data indicate that TLR7 and TLR9 costimulation do not combine synergistically for IFN-alpha induction and demonstrate that, instead, a negative feedback mechanism has evolved, possibly to prevent levels of IFN-alpha secretion potentially detrimental to the host.
Structure−Activity Studies and Analgesic Efficacy of<i>N-</i>(3-Pyridinyl)-Bridged Bicyclic Diamines, Exceptionally Potent Agonists at Nicotinic Acetylcholine Receptors (2007)

A series of exceptionally potent agonists at neuronal nicotinic acetylcholine receptors (nAChRs) has been investigated. Several N-(3-pyridinyl) derivatives of bridged bicyclic diamines exhibit double-digit-picomolar binding affinities for the alpha 4 beta 2 subtype, placing them with epibatidine among the most potent nAChR ligands described to date. Structure-activity studies have revealed that substitutions, particularly hydrophilic groups in the pyridine 5-position, differentially modulate the agonist activity at ganglionic vs central nAChR subtypes, so that improved subtype selectivity can be demonstrated in vitro. Analgesic efficacy has been achieved across a broad range of pain states, including rodent models of acute thermal nociception, persistent pain, and neuropathic allodynia. Unfortunately, the hydrophilic pyridine substituents that were shown to enhance agonist selectivity for central nAChRs in vitro tend to limit CNS penetration in vivo, so that analgesic efficacy with an improved therapeutic window was not realized with those compounds.
Electromagnetic fields and waves (1994)

Electromagnetic fields and waves , Electromagnetic fields and waves , کتابخانه دیجیتال جندی شاپور اهواز
Photocrosslinkable Vinyl Esters with α, β-Unsaturated Ketone Groups in the Backbone (1990)

Abstract Five vinyl esters with α, β-unsaturated ketone groups in their backbones have been synthesized from the corresponding diepoxides and acrylic acid with benzyltrimethylammonium methoxide as catalyst. the resins have been characterized by UV, IR, and mass spectral analysis, and their photoreactions have been studied under intense UV irradiation. the vinyl esters have been found to crosslink with UV light much faster than the parent diepoxides. on the other hand, a vinyl ester obtained from diglycidyl ether of Bisphenol A (VE) without the α, β-unsaturated ketonic group undergoes very slow photocrosslinking. Interestingly, the vinyl esters also cure chemically with styrene, methyl ethyl ketone (MEK) peroxide, and cobalt naphthenate within 30 min at 98°C, with the exception that VE does not crosslink under similar conditions. This leads to the conclusion that synergy in photo- and chemical curing can be obtained by symmetrically coupling the vinyl end groups of vinyl esters with the α, β- unsaturated ketonic moiety.
Nutrition, Epigenetics, and Metabolic Syndrome (2011)

Much work is needed with animal models to understand the basic mechanisms responsible for the roles of specific nutrients in fetal and neonatal programming. Such new knowledge is crucial to design effective therapeutic strategies for preventing and treating metabolic abnormalities in offspring born to mothers with a previous experience of malnutrition.
Hemolytic anemia associated with intravenous immunoglobulin (1997)

Intravenous immunoglobulin (IVIg) is a useful tool in the treatment of a variety of neuromuscular disorders. Though IVIg therapy is generally safe, hemolytic anemia is a potentially serious complication that is often overlooked, and is currently not listed in product inserts. We analyzed 45 patients who received IVIg therapy, including 38 consecutive patients who received IVIg over a 13-month period. On 42 patients, direct antiglobulin testing was performed, searching for antibodies to the patients' own blood type. Of these 42 patients, 12 developed passive sensitization with antibodies to their own blood group antigens after receiving IVIg. Of these 12 patients, 11 patients developed hemolysis severe enough to lower the hemoglobin level by at least 1 g/dL. Of these patients, 3 required blood transfusion, and 1 had IVIg therapy truncated because of the hemolysis. Antibodies to blood group antigens are found in all commercial preparations of IVIg. Though most patients do not have clinically significant hemolysis, clinicians should be aware of this potentially serious complication. Careful monitoring of hemoglobin levels during IVIg therapy is recommended.
HDRchitecture (2012)

The history of HDR (high dynamic range) imaging in digital photography goes back 19 years, as Robertson et al. state[2]: