gebhart/patrepeval huggingface dataset:
Shape model of the maxillary dental arch using fourier descriptors with an application in the rehabilitation for edentulous patient (2013)

The knowledge of teeth positions on the maxillary arch is useful in the rehabilitation of the edentulous patient. A combination of angular (θ), and linear (l) variables representing position of four teeth were initially proposed as the shape descriptor of the maxillary dental arch. Three categories of shape were established, each having a multivariate normal distribution. It may be argued that 4 selected teeth on the standardized digital images of the dental casts could be considered as insufficient with respect to representing shape. However, increasing the number of points would create problems with dimensions and proof of existence of the multivariate normal distribution is extremely difficult. This study investigates the ability of Fourier descriptors (FD) using all maxillary teeth to find alternative shape models. Eight FD terms were sufficient to represent 21 points on the arch. Using these 8 FD terms as an alternative shape descriptor, three categories of shape were verified, each category having the complex normal distribution.
A second site specific endonuclease from Thermus thermophilus 111, Tth111II (1980)

A second site specific endonuclease with novel specificity has been purified from Thermus thermophilus strain 111 and named Tth111II. The enzyme is active at temperature up to 80 degrees C and requires Mg2+ or Mn2+ for endonuclease activity. Tth111II cleaves phi X174RFDNA into 11 fragments and lambda NA into more than 25 fragments. From the 5'-terminal sequences of TthlllII fragments of phi X174RFDNA determined by the two dimensional homochromatography and the survey on nucleotide sequence of phi X174RFDNA, it was concluded that Tth111II recognizes the DNA sequence (see former index) and cleaves the sites as indicated by the arrows.
ChemInform Abstract: AMINO ACID SYNTHESIS. II. AMIDOALKYLATION OF OLEFINS WITH GLYOXYLIC ACID DERIVATIVES (1976)

Abstract In Gegenwart von sauren Katalysatoren erhält man aus den Olefinen (I) und dem Methyla‐methoxy‐hippurat (II) die ungesättigten Amidester (III), die alkalisch zu (IV) verseift und dann sauer zu (V) cyclisiert werden.
RAID Levels and Logical Volumes (2004)

Direct-attached storage and Network Attached Storage have a great many components that work exactly alike. At this point in the discussion, I want to move to the storage stack itself and leave the implications of moving data across a network. In this chapter, you'll see the options that are available to a Storage Area Network for protecting and preserving data, as well as strategies for minimizing the performance penalty paid for that protection.
Acceleration by MS-818 of early muscle regeneration and enhanced muscle recovery after surgical transection (2002)

The synthesized pyrimidine compound MS-818 has neurotrophic effects in several kinds of neuronal cells, but its effect with respect to muscle cells remains unknown. We therefore examined the effects of MS-818 on regeneration for 12 weeks in a wounded area (damaged and gap areas) of cut muscle in adult rats. The right semitendinosus muscles of reated and control groups were severed and sutured at the belly and the left semitendinosus muscles were left intact. MS-818 was administered intraperitoneally to the treated group at a dose of 5 mg/kg once daily. Control rats received an equal volume of physiological saline. A reference group underwent no surgical procedure. MS-818 significantly increased the maximal isometric twitch tension (Tmax) compared to control and reference rats after week 4 (approximately 1.4-fold control value; 0.6-fold reference value). Northern blotting showed that MS-818 enhanced myogenin mRNA expression to about 1.5-fold above the control level at 2, 4, and 7 days after surgery. Immunohistochemical and histochemical studies showed significant enhancement in the treated group since myogenic cells expressed desmin and were positive for neonatal myosin, and the fiber diameters and numbers of premature myofibers and end plates were increased when compared with those in the control group. These results show that MS-818 accelerated the proliferation and differentiation of activated satellite cells and the fusion of myotubes to form immature myofibers. At week 12, Tmax, fiber diameter, and number of end plates in the treatment group recovered 60, 85, and more than 100%, respectively, compared to the reference group. The mechanism of MS-818 effects on the accelerated regeneration of cut muscle is discussed. © 2002 John Wiley & Sons, Inc. Muscle Nerve 25: 218–229, 2002 DOI 10.1002/mus.10028
Controlled drug release to cancer cells from modular one-photon visible light-responsive micellar system (2016)

We present a one-photon visible light-responsive micellar system for efficient, on-demand delivery of small molecules. Release is mediated by a novel class of photochromic material - donor-acceptor Stenhouse adducts (DASAs). We demonstrate controlled delivery of small molecules such as the chemotherapeutic agent (paclitaxel) to human breast cancer cells triggered by micellar switching with low intensity, visible light.
N‐terminal engineering of amyloid‐β‐binding Affibody molecules yields improved chemical synthesis and higher binding affinity (2010)

The aggregation of amyloid-β (Aβ) peptides is believed to be a major factor in the onset and progression of Alzheimer's disease. Molecules binding with high affinity and selectivity to Aβ-peptides are important tools for investigating the aggregation process. An Aβ-binding Affibody molecule, ZAβ3 , has earlier been selected by phage display and shown to bind Aβ(1-40) with nanomolar affinity and to inhibit Aβ-peptide aggregation. In this study, we create truncated functional versions of the ZAβ3 Affibody molecule better suited for chemical synthesis production. Engineered Affibody molecules of different length were produced by solid phase peptide synthesis and allowed to form covalently linked homodimers by S-S-bridges. The N-terminally truncated Affibody molecules ZAβ3 (12-58), ZAβ3 (15-58), and ZAβ3 (18-58) were produced in considerably higher synthetic yield than the corresponding full-length molecule ZAβ3 (1-58). Circular dichroism spectroscopy and surface plasmon resonance-based biosensor analysis showed that the shortest Affibody molecule, ZAβ3 (18-58), exhibited complete loss of binding to the Aβ(1-40)-peptide, while the ZAβ3 (12-58) and ZAβ3 (15-58) Affibody molecules both displayed approximately one order of magnitude higher binding affinity to the Aβ(1-40)-peptide compared to the full-length Affibody molecule. Nuclear magnetic resonance spectroscopy showed that the structure of Aβ(1-40) in complex with the truncated Affibody dimers is very similar to the previously published solution structure of the Aβ(1-40)-peptide in complex with the full-length ZAβ3 Affibody molecule. This indicates that the N-terminally truncated Affibody molecules ZAβ3 (12-58) and ZAβ3 (15-58) are highly promising for further engineering and future use as binding agents to monomeric Aβ(1-40).
Effect of lyophilization and storage temperature on the activity of salivaricin CRL 1328, a potential bioactive ingredient of a urogenital probiotic product (2012)

Bacteriocins are antimicrobial peptides with potential applications as therapeutic agents for the treatment of microbial infections. The aim of this work was to investigate the effect of different protectors on the activity of salivaricin CRL1328, a bacteriocin produced by Lactobacillus salivarius CRL1328, during the lyophilization process and subsequent storage at different temperatures for 18 months using statistical models. Different protectors such as mannitol, Tween 80, polyethylene glycol 8000 (PEG), monosodium glutamate (MSG), reconstituted skim milk, sucrose and ascorbic acid were used for the lyophilization and storage of salivaricin. The biplot of principal component analysis was used for the interpretation of the interactions between the different factors studied. The antimicrobial activity of salivaricin was dependent mainly on temperature, and also on the time of storage and protector assayed. The stability of salivaricin was higher at -20°C and 4°C than 25°C and decreased during the time of storage; however, salivaricin was active after 18 months of storage at 25°C. Sucrose, mannitol plus sucrose, PEG plus sucrose and MSG were the most effective agents in protecting the bacteriocin during the lyophilization process. Effective maintenance of the activity of the bacteriocin was observed by storage with sucrose and ascorbic acid at -20°C as well as with PEG plus sucrose at 4°C and -20°C. The results obtained suggest that sucrose alone or combined with PEG can effectively maintain the activity of salivaricin during lyophilization and storage. This study provides useful information for the potential application of salivaricin as a bioactive principle for a pharmaceutical formulation.
Open Web Services Testing (2011)

The advance in web services (WS) and service oriented architecture (SOA) applications has led to the development of new types of systems in which different heterogeneous components and platforms can connect and collaborate to solve a business problem. This advancement adds a new level of abstraction to the existing stack of technologies and development methodologies, but it adds also new challenges. One such a big challenge is testing. From the client prospective, a Web Service is a black box that needs to be tested before being used, mainly to confirm the claims of services' providers about the quality of their services. By calling a WS, we delegate part of our business logic to an external provider to do it for us. Thus, we have no control of what could happen during the execution of that part of the business logic. To this end, many testing approaches and techniques have been proposed in the literature to address various aspects related to WS testing. In our effort to improve WS testing infrastructures, we propose a framework for service integrators to collaborate during Web Services testing by making test suites open to the public and share testing results.
OPTIMIZATION OF RUBBER FORMULATION FOR SILICA-REINFORCED NATURAL RUBBER COMPOUNDS (2013)

ABSTRACT The rubber formulation plays a significant role in the properties of NR compounds filled with silica. In this work, the influences of various silicas, silane coupling agents, and diphenylguanidine (DPG) on the properties of compounds and vulcanizates—that is, cure characteristics, Mooney viscosity, flocculation kinetics, bound rubber content, Payne effect, tan δ at 60°C, tensile properties, and tear properties—are investigated. The results demonstrate that compound viscosity and curing behavior, as well as vulcanizate properties of the silica-filled NR, are much improved by incorporating silane coupling agents. Bis-triethoxysilylpropyltetrasulfide clearly gives better overall properties than the disulfide-based silane bis-triethoxysilylpropyldisulfide, except for scorch safety. DPG acts as a synergist to sulfenamide primary accelerators, as well as activator for the silanization reaction. Highly dispersible (HD) silicas can significantly enhance the degree of dispersion and so lead to higher filler–rubber interaction. As a consequence, the HD silicas provide better dynamic and mechanical properties for filled NR vulcanizates compared with conventional counterparts. The optimal quantities of both silane coupling agent and DPG required in the formulation are correlated to the cetyl trimethylammonium bromide specific surface area of the silicas. Furthermore, the results reveal that the silica structure as characterized by the dibutylphthalate adsorption also strongly influences the reinforcing efficiency.
An Interactive Computer-Based Circulation System for Northwestern University: The Library Puts It to Work (1972)

Northwestern University Library's on-line circulation system has resulted in dramatic changes in practices and procedures in the Circulation Services Section. After a hectic period of implementation, the staff soon began to adjust to the system. Over the past year and a half, they have devised ways to use the system to maximum advantage, so that manual and machine systems now mesh in close harmony. Freed from time-consuming clerical chores, the staff have been challenged to use their released time to best advantage, with the result that the "service" in "Circulation Services" is much closer to being a reality.
Mechanism of action of novel NO‐releasing furoxan derivatives of aspirin in human platelets (2006)

Incorporation of a nitric oxide (NO)-releasing moiety in aspirin can overcome its gastric side effects. We investigated the NO-release patterns and antiplatelet effects of novel furoxan derivatives of aspirin (B8 and B7) in comparison to existing antiplatelet agents. Cyclooxygenase (COX) activity was investigated in purified enzyme using an electron paramagnetic resonance-based technique. Concentration-response curves for antiplatelet agents +/- the soluble guanylate cyclase inhibitor, ODQ (50 microM) were generated in platelet-rich plasma (PRP) and washed platelets (WP) activated with collagen using turbidometric aggregometry. NO was detected using an isolated NO electrode. The furoxan derivatives of aspirin (B8, B7) and their NO-free furazan equivalents (B16, B15; all 100 microM) significantly inhibited COX activity (P < 0.01; n = 6) in vitro and caused aspirin-independent, cGMP-dependent inhibition of collagen-induced platelet aggregation in WP. B8 was more potent than B7 (PRP IC(50) = 0.62 +/- 0.1 microM for B8; 400 +/- 89 microM for B7; P < 0.0001. WP IC(50)s = 0.6 +/- 0.1 and 62 +/- 10 microM, respectively). The NO-free furazan counterparts were less potent antiplatelet agents (WP IC(50)s = 54 +/- 3 microM and 62 +/- 10 microM, respectively; P < 0.0001, B8 vs B16). Of the hybrids investigated, only B8 retained antiplatelet activity in PRP.NO release from furoxan-aspirin hybrids was undetectable in buffer alone, but was accelerated in the presence of either plasma or plasma components, albumin (4%), glutathione (GSH; 3 microM) and ascorbate (50 microM), the effects of which were additive for B7 but not B8. NO generation from furoxans was greatly enhanced by platelet extract, an effect that could largely be explained by the synergistic effect of intracellular concentrations of GSH (3 mM) and ascorbate (1 mM). We conclude that the decomposition of furoxan-aspirin hybrids to generate biologically active NO is catalysed by endogenous agents which may instil a potential for primarily intracellular delivery of NO. The blunting of the aspirin effects of furoxan hybrids is likely to be due to loss of the acetyl moiety in plasma; the observed antiplatelet effects are thereby primarily mediated via NO release. Compounds of this class might represent a novel means of inhibiting platelet aggregation by a combination of NO generation and COX inhibition.
Synthesis and photoluminescence studies on ZnO nanowires (2004)

ZnO nanowires were grown in gram quantities on graphite flakes (as collector) using the vapour transport and condensation approach. The yield, defined as the weight ratio of ZnO nanowires to the original graphite flakes, has been studied thoroughly by tuning the various growth parameters such as pressure and temperature inside the tube furnace, the amount of graphite powder in the original source, the source to collector ratio, etc. A yield as high as 200% has been achieved, equivalent to a 40% conversion of the ZnO powder in the original source. A study comparing the photoluminescence spectra of the ZnO nanowires grown on both graphite flakes and substrates with commercially available ZnO powder has been carried out.
What Is the Predictability Limit of Midlatitude Weather? (2019)

Abstract Understanding the predictability limit of day-to-day weather phenomena such as midlatitude winter storms and summer monsoonal rainstorms is crucial to numerical weather prediction (NWP). This predictability limit is studied using unprecedented high-resolution global models with ensemble experiments of the European Centre for Medium-Range Weather Forecasts (ECMWF; 9-km operational model) and identical-twin experiments of the U.S. Next-Generation Global Prediction System (NGGPS; 3 km). Results suggest that the predictability limit for midlatitude weather may indeed exist and is intrinsic to the underlying dynamical system and instabilities even if the forecast model and the initial conditions are nearly perfect. Currently, a skillful forecast lead time of midlatitude instantaneous weather is around 10 days, which serves as the practical predictability limit. Reducing the current-day initial-condition uncertainty by an order of magnitude extends the deterministic forecast lead times of day-to-day weather by up to 5 days, with much less scope for improving prediction of small-scale phenomena like thunderstorms. Achieving this additional predictability limit can have enormous socioeconomic benefits but requires coordinated efforts by the entire community to design better numerical weather models, to improve observations, and to make better use of observations with advanced data assimilation and computing techniques.
E-cadherin and loss of heterozygosity at chromosome 16 in breast carcinogenesis: different genetic pathways in ductal and lobular breast cancer? (2001)

Loss of heterozygosity at the long arm of chromosome 16 is one of the most frequent genetic events in breast cancer. In the search for tumour suppressor genes that are the target of loss of heterozygosity at 16q, the E-cadherin gene CDH1 was unveiled by the identification of truncating mutations in the retained copy. However, only lobular tumours showed E-cadherin mutations. Whereas investigations are still devoted to finding the target genes in the more frequent ductal breast cancers, other studies suspect the E-cadherin gene to also be the target in this tumour type. The present article discusses the plausibility of those two lines of thought.
Spatial graph grammars for graphical user interfaces (2006)

In a graphical user interface, physical layout and abstract structure are two important aspects of a graph. This article proposes a new graph grammar formalism which integrates both the spatial and structural specification mechanisms in a single framework. This formalism is equipped with a parser that performs in polynomial time with an improved parsing complexity over its nonspatial predecessor, that is, the Reserved Graph Grammar. With the extended expressive power, the formalism is suitable for many user interface applications. The article presents its application in adaptive Web design and presentation.
Developmental roles and molecular characterization of a <i>Drosophila</i> homologue of <i>Arabidopsis Argonaute1</i>, the founder of a novel gene superfamily (2001)

Our results suggest that the dAGO1 protein exerts its developmental functions by binding to RNA either directly or indirectly.
Advanced Energetic Materials Emerge For Military and Space Applications (1994)

RETURN TO ISSUEPREVNewsNEXTAdvanced Energetic Materials Emerge For Military and Space Applications? A new generation of propellants and explosives is being developed by teams of chemists in industrial and government labsSTU BORMANView Author Information C&EN WashingtonCite this: Chem. Eng. News 1994, 72, 3, 18–22Publication Date (Print):January 17, 1994Publication History Published online11 November 2010Published inissue 17 January 1994https://pubs.acs.org/doi/10.1021/cen-v072n003.p018https://doi.org/10.1021/cen-v072n003.p018newsACS PublicationsCopyright © 1994 American Chemical SocietyArticle Views37Altmetric-Citations63LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options SUBJECTS:Materials Get e-Alerts
26 GHz TM/sub 11δ/ mode dielectric resonator filter and duplexer with high-Q performance and compact configuration (2003)

A novel structure of 26 GHz bandpass filters using TM/sub 11/spl delta// rectangular-mode dielectric cavity resonators is introduced. The resonator of high-permittivity ceramics shows a high quality factor (Q) value of 2600, which is roughly comparable to that of waveguide type ones, in spite of its small structure. A three-stage Tchebyscheff bandpass filter with 0.4% relative bandwidth was fabricated and the passband insertion loss was measured to be 1.7 dB. The filter has input/output ports of microstrip lines for the surface mounting. A duplexer, consisting only of two TM/sub 11/spl delta// mode filters and a microstrip T-junction, is also presented. These filter and duplexer have a configuration compact and easy to manufacture as well as the high-Q performance.
Ca2+-dependent hydrophobic-interaction chromatography. Isolation of a novel Ca2+-binding protein and protein kinase C from bovine brain (1984)

Several bovine brain proteins have been found to interact with a hydrophobic chromatography resin (phenyl-Sepharose CL-4B) in a Ca2+-dependent manner. These include calmodulin, the Ca2+/phospholipid-dependent protein kinase (protein kinase C) and a novel Ca2+-binding protein that has now been purified to electrophoretic homogeneity. This latter protein is acidic (pI 5.1) and, like calmodulin and some other high-affinity Ca2+-binding proteins, exhibits a Ca2+-dependent mobility shift on sodium dodecyl sulphate/polyacrylamide-gel electrophoresis, with an apparent Mr of 22 000 in the absence of Ca2+ and Mr 21 000 in the presence of Ca2+. This novel calciprotein is distinct from known Ca2+-binding proteins on the basis of Mr under denaturing conditions, Cleveland peptide mapping and amino acid composition analysis. It may be a member of the calmodulin superfamily of Ca2+-binding proteins. This calciprotein does not activate two calmodulin-dependent enzymes, namely cyclic nucleotide phosphodiesterase and myosin light-chain kinase, nor does it have any effect on protein kinase C. It may be a Ca2+-dependent regulatory protein of an as-yet-undefined enzymic activity. The Ca2+/phospholipid-dependent protein kinase is also readily purified by Ca2+-dependent hydrophobic-interaction chromatography followed by ion-exchange chromatography, during which it is easily separated from calmodulin. A preparation of protein kinase C that lacks contaminating kinase or phosphatase activities is thereby obtained rapidly and simply. Such a preparation is ideal for the study of phosphorylation reactions catalysed in vitro by protein kinase C.