gebhart/patrepeval huggingface dataset:
Dual arm master controller concept (1984)

The Advanced Servomanipulator (ASM) slave was designed with an anthropomorphic stance, gear/torque tube power drives, and modular construction. These features resulted in increased inertia, friction, and backlash relative to tape-driven manipulators. Studies were performed which addressed the human factors design and performance trade-offs associated with the corresponding master controller best suited for the ASM. The results of these studies, as well as the conceptual design of the dual arm master controller, are presented. 6 references, 3 figures.
Simple, efficient total synthesis of cantharidin via a high-pressure Diels-Alder reaction (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSimple, efficient total synthesis of cantharidin via a high-pressure Diels-Alder reactionWilliam G. Dauben, Carl R. Kessel, and Kazuo H. TakemuraCite this: J. Am. Chem. Soc. 1980, 102, 22, 6893–6894Publication Date (Print):October 15, 1980Publication History Published online1 May 2002Published inissue 15 October 1980https://pubs.acs.org/doi/10.1021/ja00542a060https://doi.org/10.1021/ja00542a060research-articleACS PublicationsRequest reuse permissionsArticle Views1618Altmetric-Citations104LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Sensors: Stretchable, Multiplexed pH Sensors With Demonstrations on Rabbit and Human Hearts Undergoing Ischemia (Adv. Healthcare Mater. 1/2014) (2014)

On page 59, John A. Rogers and team present precise spatiotemporal mapping of pH on the epicardial surface by an ultrathin stretchable electronic device. The results illustrate that advanced strategies in materials assembly and electrochemical growth can yield interconnected arrays of miniaturized IrOx pH sensors encapsulated in thin, low-modulus elastomers to yield conformal monitoring systems capable of non-invasive measurements on the surface of the beating heart.
Techniques to improve performance in requester-wins hardware transactional memory (2013)

The simplicity of requester-wins Hardware Transactional Memory (HTM) makes it easy to incorporate in existing chip multiprocessors. Hence, such systems are expected to be widely available in the near future. Unfortunately, these implementations are prone to suffer severe performance degradation due to transient and persistent livelock conditions. This article shows that existing techniques are unable to mitigate this degradation effectively. It then proposes and evaluates four novel techniques—two software-based that employ information provided by the hardware and two that require simple core-local hardware additions—which have the potential to boost the performance of requester-wins HTM designs substantially.
Regulation of hexuronate system genes in Escherichia coli K-12: multiple regulation of the uxu operon by exuR and uxuR gene products (1981)

New regulatory mutants of Escherichia coli K-1 carrying alterations of the uxuR gene were isolated and characterized. In the presence of superrepressed or derepressed uxuR mutations, mannonic hydrolyase (uxuA) and oxidoreductase relationship analyses suggested that the uxuR gene product acted as a repressor in the control of uxuA-uxuB operon expression. uxuR mutations were localized near min 97, and the following gene order was established: (argH)-uxuR-uxuB-uxuA-(thr). Properties of exuR (point and deletion) mutants showed that both exuR and uxuR regulatory gene products were involved in the control of the uxuA uxuB operon. Analysis of exuR uxuR double-derepressed mutants suggested that exuR and uxuR repressors act cooperatively to repress the uxu operon.
Cooperative caching of dynamic content on a distributed Web server (2002)

We propose a new method for improving the average response time of Web servers by cooperatively caching the results of requests for dynamic content. The work is motivated by our recent study of access logs from the Alexandria Digital Library server at UCSB, which demonstrates that approximately a 30 percent decrease in average response time could be achieved by caching dynamically generated content. We have developed a distributed Web server called Swala, in which the nodes cooperatively cache the results of CGI requests, and the cache meta-data is stored in a replicated global cache directory. Our experiments show that the single-node performance of Swala without caching is comparable to the Netscape Enterprise server, that considerable speedups are obtained using caching, and that the cache hit ratio is substantially higher with cooperative cache than with stand-alone cache.
Biocomposites based on poly(lactic acid)/willow-fiber and their injection moulded microcellular foams (2015)

Natural fiber reinforced biocomposites have recently attracted many researchers because of their biodegradability, cost effectiveness and ecofriendliness. The present study investigates the properties of willow-fiber reinforced poly(lactic acid) based composites and their foam processability. Microcellular foams of the composites were prepared by foam injection moulding using nitrogen gas as the blowing agent. The effects of willow-fiber addition on the morphology, mechanical properties, thermal stability, crystallization, and heat deflection temperature (HDT) were studied. At 30 weight percent [wt%] willow-fiber content, unfoamed composites showed good improvement in specific tensile and flexural moduli. Addition of willow-fiber increased crystallinity and the rate of crystallization and yielded narrow crystallite size distribution as observed by differential scanning calorimetry (DSC). Scanning electron microscopy (SEM) results of the foamed composites revealed that increase in willow-fiber content caused smaller average cell size and higher cell density. Specific notch impact strength of foamed composites at both 20 and 30 wt% willow-fiber content showed increasing trend compared to that of their unfoamed counterparts.
SPICE MODEL FOR TRANSIENT ANALYSIS OF EEPROM CELLS (1988)

An equivalent model for the EEPROM cell, described on a SPICE circuit analyzer, is used for the transient analysis of erase(E)/write(W) characteristics with ramp waveform programming pulses. The results of the simulation are compared with the experimental data obtained by an innovative method for measuring E/W curves. The validation of the model is made over different variations of the cell lay-out, different programming voltages and different rise times for the ramp of the programming pulse.
A 500 MHz 64b RISC CPU with 1.5 MB on-chip cache (2003)

A 64b quad issue PA-RISC microprocessor with full out-of-order execution is migrated from 0.5 /spl mu/m CMOS into an advanced 0.25 /spl mu/m CMOS process. Features include an integrated on-chip 1.0 MB L1 data and 0.5 MB L1 instruction caches and a dual-voltage memory bus interface. The processor incorporates 116 M transistors on a 21.3/spl times/22 mm/sup 2/ die running in excess of 50O MHz at 85/spl deg/C and 2.0 V and delivering greater than 32 SPECint95 and greater than 52 SPECfp95 in a 440 MHz product configuration.
The Effect of Antacid and Ranitidine on Droxicam Pharmacokinetics (1992)

Droxicam is a nonsteroidal anti-inflammatory drug that is a pro-drug of piroxicam. The influence of concomitant administration of antacid or ranitidine on droxicam pharmacokinetics has been investigated. On three separate phases, 15 healthy volunteers received a single oral 20-mg dose of droxicam either alone, with antacid (400 mg aluminum hydroxide + 400 mg magnesium hydroxide, three times/day), or with ranitidine (300 mg, two times/day) for 6 days. Piroxicam, the active substance from droxicam, was quantified by high-performance liquid chromatography. The pharmacokinetic parameters for droxicam given alone were: maximum peak plasma concentration (Cmax) = 1.53 +/- .21 micrograms/mL (mean +/- SD), time to peak concentration (Tmax) = 7.5 +/- 2.1 hr, t1/2a = 1.38 +/- .82 hour, t1/2el = 53.3 +/- 11.9 hr, Cl/F = 2.98 +/- .71 mL/min, volume of distribution (Vd/F) = 13.2 +/- 1.8 L and area under the curve (AUC) = 117.6 +/- 26.8 micrograms/hour/mL. The subject effect was significant for all the pharmacokinetic parameters except for the absorption half-life (P < .05). Concomitant antacid or ranitidine administration had no significant effect on any of the droxicam pharmacokinetic parameters. The results of this study suggest that antacid or ranitidine do not significantly alter the oral absorption or pharmacokinetic disposition of single-dose droxicam.
Makeup Lamps: Live Augmentation of Human Faces via Projection (2017)

We propose the first system for live dynamic augmentation of human faces. Using projector-based illumination, we alter the appearance of human performers during novel performances. The key challenge of live augmentation is latency — an image is generated according to a specific pose, but is displayed on a different facial configuration by the time it is projected. Therefore, our system aims at reducing latency during every step of the process, from capture, through processing, to projection. Using infrared illumination, an optically and computationally aligned high-speed camera detects facial orientation as well as expression. The estimated expression blendshapes are mapped onto a lower dimensional space, and the facial motion and non-rigid deformation are estimated, smoothed and predicted through adaptive Kalman filtering. Finally, the desired appearance is generated interpolating precomputed offset textures according to time, global position, and expression. We have evaluated our system through an optimized CPU and GPU prototype, and demonstrated successful low latency augmentation for different performers and performances with varying facial play and motion speed. In contrast to existing methods, the presented system is the first method which fully supports dynamic facial projection mapping without the requirement of any physical tracking markers and incorporates facial expressions.
SmI<sub>2</sub>‐Induced Umpolung of the CN Bond: First Reductive Conjugate Addition of Nitrones to α,β‐Unsaturated Esters (2003)

Enantioselective approach to γ-amino acid derivatives: Umpolung of the CN bond of nitrones by reduction with SmI2, generates a species that adds smoothly to α,β-unsaturated esters. The corresponding γ-N-hydroxyamino esters are obtained with excellent stereoselection (see scheme).
Testing for Differentially-Expressed Genes by Maximum-Likelihood Analysis of Microarray Data (2000)

Although two-color fluorescent DNA microarrays are now standard equipment in many molecular biology laboratories, methods for identifying differentially expressed genes in microarray data are still evolving. Here, we report a refined test for differentially expressed genes which does not rely on gene expression ratios but directly compares a series of repeated measurements of the two dye intensities for each gene. This test uses a statistical model to describe multiplicative and additive errors influencing an array experiment, where model parameters are estimated from observed intensities for all genes using the method of maximum likelihood. A generalized likelihood ratio test is performed for each gene to determine whether, under the model, these intensities are significantly different. We use this method to identify significant differences in gene expression among yeast cells growing in galactose-stimulating versus non-stimulating conditions and compare our results with current approaches for identifying differentially-expressed genes. The effect of sample size on parameter optimization is also explored, as is the use of the error model to compare the within- and between-slide intensity variation intrinsic to an array experiment.
An Augmented Reality System for Astronomical Observations (2006)

Anyone who has gazed through the eyepiece of an astronomical telescope knows that, with the exception of the Moon and the planets, extra-solar astronomical objects are disappointing to observe visually. This is mainly due to their low surface brightness, but also depends on the visibility, sky brightness and telescope aperture. We propose a system which projects images of astronomical objects (with focus on nebulae and galaxies), animations and additional information directly into the eyepiece view of an astronomical telescope. As the telescope orientation is queried continuously, the projected image is adapted in real-time to the currently visible field of view. For projection, a custom-built video projection module with high contrast and low maximum luminance value was developed. With this technology visitors to public observatories have the option to experience the richness of faint astronomical objects while directly looking at them through a telescope.
Controlling Hybridization Chain Reactions with pH (2015)

By taking inspiration from nature, where self-organization of biomolecular species into complex systems is finely controlled through different stimuli, we propose here a rational approach by which the assembly and disassembly of DNA-based concatemers can be controlled through pH changes. To do so we used the hybridization chain reaction (HCR), a process that, upon the addition of an initiator strand, allows to create DNA-based concatemers in a controlled fashion. We re-engineered the functional units of HCR through the addition of pH-dependent clamp-like triplex-forming domains that can either inhibit or activate the polymerization reaction at different pHs. This allows to finely regulate the HCR-induced assembly and disassembly of DNA concatemers at either basic or acidic pHs in a reversible way. The strategies we present here appear particularly promising as novel tools to achieve better spatiotemporal control of self-assembly processes of DNA-based nanostructures.
Flux Balance Analysis with Objective Function Defined by Proteomics Data—Metabolism of Mycobacterium tuberculosis Exposed to Mefloquine (2015)

We present a study of the metabolism of the Mycobacterium tuberculosis after exposure to antibiotics using proteomics data and flux balance analysis (FBA). The use of FBA to study prokaryotic organisms is well-established and allows insights into the metabolic pathways chosen by the organisms under different environmental conditions. To apply FBA a specific objective function must be selected that represents the metabolic goal of the organism. FBA estimates the metabolism of the cell by linear programming constrained by the stoichiometry of the reactions in an in silico metabolic model of the organism. It is assumed that the metabolism of the organism works towards the specified objective function. A common objective is the maximization of biomass. However, this goal is not suitable for situations when the bacterium is exposed to antibiotics, as the goal of organisms in these cases is survival and not necessarily optimal growth. In this paper we propose a new approach for defining the FBA objective function in studies when the bacterium is under stress. The function is defined based on protein expression data. The proposed methodology is applied to the case when the bacterium is exposed to the drug mefloquine, but can be easily extended to other organisms, conditions or drugs. We compare our method with an alternative method that uses experimental data for adjusting flux constraints. We perform comparisons in terms of essential enzymes and agreement using enzyme abundances. Results indicate that using proteomics data to define FBA objective functions yields less essential reactions with zero flux and lower error rates in prediction accuracy. With flux variability analysis we observe that overall variability due to alternate optima is reduced with the incorporation of proteomics data. We believe that incorporating proteomics data in the objective function used in FBA may help obtain metabolic flux representations that better support experimentally observed features.
Secure Management of Biomedical Data With Cryptographic Hardware (2011)

The biomedical community is increasingly migrating toward research endeavors that are dependent on large quantities of genomic and clinical data. At the same time, various regulations require that such data be shared beyond the initial collecting organization (e.g., an academic medical center). It is of critical importance to ensure that when such data are shared, as well as managed, it is done so in a manner that upholds the privacy of the corresponding individuals and the overall security of the system. In general, organizations have attempted to achieve these goals through deidentification methods that remove explicitly, and potentially, identifying features (e.g., names, dates, and geocodes). However, a growing number of studies demonstrate that deidentified data can be reidentified to named individuals using simple automated methods. As an alternative, it was shown that biomedical data could be shared, managed, and analyzed through practical cryptographic protocols without revealing the contents of any particular record. Yet, such protocols required the inclusion of multiple third parties, which may not always be feasible in the context of trust or bandwidth constraints. Thus, in this paper, we introduce a framework that removes the need for multiple third parties by collocating services to store and to process sensitive biomedical data through the integration of cryptographic hardware. Within this framework, we define a secure protocol to process genomic data and perform a series of experiments to demonstrate that such an approach can be run in an efficient manner for typical biomedical investigations.
Octaazacryptand Complexation of the Fluoride Ion (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOctaazacryptand Complexation of the Fluoride IonSean D. Reilly, Guru Rattan K. Khalsa, Doris K. Ford, James R. Brainard, Benjamin P. Hay, and Paul H. SmithCite this: Inorg. Chem. 1995, 34, 3, 569–575Publication Date (Print):February 1, 1995Publication History Published online1 May 2002Published inissue 1 February 1995https://pubs.acs.org/doi/10.1021/ic00107a008https://doi.org/10.1021/ic00107a008research-articleACS PublicationsRequest reuse permissionsArticle Views257Altmetric-Citations52LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Introducing the Concepts of Electoral, Production, Credit and Food Production Processes (1983)

Rather than simply contrast state institutions with private institutions as belonging to separate realms — each governed by inherently different forms of rationality — Electoral, Production, Credit and Food Production Processes are concepts which attempt to explain the overlapping and interdependent relations between state institutions and private institutions. There are, however, social practices such as judicial arbitration or the printing of money which are almost exclusive roles carried out by state institutions in most capitalist countries. But it is difficult to think of many social practices in contemporary capitalist societies which are carried out exclusively by private institutions. This is not to deny that in many capitalist countries such as the United States, state institutions are involved in less commodity production or the operation of cultural institutions and other social practices, compared to state institutions in other capitalist countries such as those in Western Europe. It is precisely these historical differences which make the concepts of Processes valuable analytical tools. Each local, regional and national Electoral, Production, Credit and Food Production Process consists of greater or fewer state-run or privately-run institutions. Whereas the concepts of 'the State', 'Civil Society' and 'the Economy' are nearly always used to delineate private institutions from state-run institutions — i.e. 'Civil Society' and 'the Economy' are supposed to be realms of only private activity — the concept of Electoral, Production, Credit and Food Production Processes cut across these traditional and artificial divisions.
Integrated Treatment with a Prescribed Burn and Postemergent Herbicide Demonstrates Initial Success in Managing Cheatgrass in a Northern Colorado Natural Area (2012)

Eradicating the invasive species cheatgrass (Bromus tectorum) presents a significant challenge to land managers across the western United States and can require integrated and adaptive management, including biological, chemical, and prescribed fire control strategies. Resource managers in the Larimer County Open Space Program in Northern Colorado began a cheatgrass reduction program at the Devil's Backbone Open Space preserve that consisted of prescribed burns in fall 2007 and spring 2008, followed by post-emergent imazapic treatments at 0.44 L/ha. The fire was characterized as a slow-moving, highly consumptive burn, and managers monitored results intermittently following the integrated treatments. Post treatment, average cheatgrass cover was reduced from 82% to 9% from 2007 to 2009 based on six permanent monitoring transects. While quantitative data was not taken for the emergence of native grasses and forbs, incidence of bare ground did not increase significantly following treatment. This case study suggests a highly consumptive burn can decrease cheatgrass from the seed bank and create favorable conditions for vegetation other than cheatgrass to return. More research and long-term monitoring building upon this pilot study could help to understand if this combined treatment is a viable long-term reduction strategy.