gebhart/patrepeval huggingface dataset:
Lewis<sup>a</sup> Substance in Saliva (1959)

Summary Rabbit anti‐Le a sera precipitate the Le a substance in saliva from Le(a+b‐) non‐secretors, but not the Le a substance in saliva from Le(a‐b+) secretors, although the latter may have considerable inhibiting titres with anti‐Le a agglutinating serum. The non‐precipitability of the Le a substance in secretor saliva does not appear to be due to low molecular weight of the blood group substance. It is suggested, instead, that in secretor saliva with Le a activity each blood group substance macromolecule has many ABH and fewer Le a specific groupings present on its surface. While there are enough ABH groupings on each molecule to permit precipitation with anti‐ABH antibody, the Le a groupings are too few to enable anti‐Le a antibody to precipitate the macromolecule. In non‐secretors, however, the macromolecule has more numerous Le a surface groups and is thus easily precipitated by anti‐Le a antibody. Résumé Le sérum anti‐Le a de lapin est capable de précipiter la substance Le a dans la salive d'individus Le(a+b‐) non‐sécréteurs, mais pas dans la salive d'individus Le(a‐b+) sécréteurs malgré que la salive de ces derniers puisse inhiber à un titre considérable l'agglutinine anti‐Le a . Le fait que la substance Le a dans la salive de sécréteurs ne puisse pas donner de précipitation ne semble pas être dûà ce que le poids moléculaire de cette substance soit trop bas. Les auteurs émettent plutôt l'hypothèse que, dans la salive de sécréteurs douée d'activité Le a chaque macromolécule de substance de groupe sanguin possède à sa surface de nombreux récepteurs ABH et peu de récepteurs Le a , de sorte qu'une précipitation avec anticorps anti‐ABH est possible tandis que le petit nombre de récepteurs Le a ne permet pas de précipitation avec l'anti‐Le a . Chez les non‐sécréteurs, par contre, la macromolécule possède de nombreux récepteurs Le a ce qui rend possible sa précipitation par l'anti‐Le a . Zusammenfassung Anti‐Le a ‐Immunseren von Kaninchen präzipitieren die im Speichel von Le(a+b‐) Nichtsekretoren enthaltene Le a ‐Substanz. Obschon der Speichel von Le(a‐b+) Sekretoren beträchtliche Mengen Le a ‐Substanz enthält, die im Agglutininhemmungsversuch mit Anti‐Le a ‐Seren ohne weiteres erfaßt werden können, wird diese durch die erwähnten Kaninchenseren nicht präzipitiert. Die Nichtpräzipitierbarkeit der im Speichel von Sekretoren enthaltenen Le a ‐Substanz beruht wahrscheinlich nicht auf einem niedrigeren Molekulargewicht dieser Blutgruppensubstanz. Die Erklärung für diese Beobachtung beruht wahrscheinlich darauf, daß die blutgruppenspezifischen Makromoleküle von Sekretoren an ihrer Oberfläche zahlreiche ABH‐Determinanten, aber nur wenige Le a ‐Determinanten aufweisen. Die zahlreichen ABH‐Determinanten bewirken eine positive Präzipitation mit Anti‐ABH‐Immunseren; die wenigen Le a ‐Determinanten reichen hingegen für eine Präzipitation mit Anti‐Le a ‐Immunseren nicht aus. Bei Nichtsekretoren weisen die blutgruppenspezifischen Makromoleküle an ihrer Oberfläche zahlreiche Le a ‐Determinanten auf, die für eine Präzipitation mit Anti‐Le a ‐Immunseren ausreichen.
Malnutrition in patients with pressure ulcers: morbidity, mortality, and clinically practical assessments. (1997)

The association between protein-calorie malnutrition and pressure ulcers is well established. Measurements of nutritional status are frequently included in the routine clinical assessment of patients with pressure ulcers. This paper reviews the associations between these measurements and the presence, severity and healing of pressure ulcers.
CRYSTALLURIA IN PATIENTS WITH CALCIUM STONE DISEASE (1999)

No AccessJournal of UrologyClinical Urology: This Month in Investigative Urology1 May 1999CRYSTALLURIA IN PATIENTS WITH CALCIUM STONE DISEASE Hans-Goran TiseliusMD, PhD Hans-Goran TiseliusHans-Goran Tiselius More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)68917-3AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "CRYSTALLURIA IN PATIENTS WITH CALCIUM STONE DISEASE." The Journal of Urology, 161(5), p. 1432 Professor of Urology; Department of Urology; Huddinge University Hospital; Karolinska Institutet; Stockholm, Sweden© 1999FiguresReferencesRelatedDetails Volume 161Issue 5May 1999Page: 1432 Advertisement Copyright & Permissions© 1999MetricsAuthor Information Hans-Goran Tiselius More articles by this author Expand All Advertisement PDF downloadLoading ...
The study of one-through solar absorber receiver (2009)

This paper introduces the configuration and components of a solar absorber receiver in the parabolic trough solar power system. The failure or degradation of the receiver, mainly including glass-to-metal sealing failure, loss of vacuum and degradation of solar selective coating, is the single largest cost factor for current and future solar power plant. The article elaborates the principle of glass-to-metal sealing and a new glass-to-metal seal technology that has been developed through a lot of experiments. The tensile tests and EPMA tests have proven the high reliability and strength of the glass-to-metal seals. The vacuum seal of glass-metal joint is tested using a helium mass spectrometer leak detector. The paper also introduces a new solar selective coating and getters used in the receiver. A process of glass to metal sealing is developed and the prototypes of solar absorber receiver are manufactured.
Crh, the paralogue of the phosphocarrier protein HPr, controls the methylglyoxal bypass of glycolysis in <i>Bacillus subtilis</i> (2011)

The histidine protein HPr has a key role in regulation of carbohydrate utilization in low-GC Gram-positive bacteria. Bacilli possess the paralogue Crh. Like HPr, Crh becomes phosphorylated by kinase HPrK/P in response to high fructose-1,6-bisphosphate concentrations. However, Crh can only partially substitute for the regulatory functions of HPr leaving its role mysterious. Using protein co-purification, we identified enzyme methylglyoxal synthase MgsA as interaction partner of Crh in Bacillus subtilis. MgsA converts dihydroxyacetone-phosphate to methylglyoxal and thereby initiates a glycolytic bypass that prevents the deleterious accumulation of phospho-sugars under carbon overflow conditions. However, methylgyloxal is toxic and its production requires control. We show here that exclusively the non-phosphorylated form of Crh interacts with MgsA in vivo and inhibits MgsA activity in vitro. Accordingly, Crh inhibits methylglyoxal formation in vivo under nutritional famine conditions that favour a low HPr kinase activity. Thus, Crh senses the metabolic state of the cell, as reflected by its phosphorylation state, and accordingly controls flux through the harmful methylglyoxal pathway. Interestingly, HPr is unable to bind and regulate MgsA, making this a bona fide function of Crh. Four residues that differ in the interaction surfaces of HPr and Crh may account for this difference.
Aminocyclopentitol Inhibitors ofα-L-Fucosidases (2001)

Aminocyclopentitol analogs of α-L-fucose were synthesized stereoselectively from D-ribose. Alkyl substituents were attached at the NH2 group to mimic the glycosidic leaving group. The resulting (alkylamino)cyclopentitols inhibited α-L-fucosidases selectively with inhibition constants in the range of Ki=10−7 M. Comparisons with stereoisomers and acyclic analogs showed that this inhibition only occurs with N-alkyl substitution and proper configuration at the cyclopentane, as expected for transition-state-analog-type inhibition. These observations were supported by molecular-modeling comparisons between inhibitor and transition state.
Trajectory Tracking for Autonomous Vehicles: An Integrated Approach to Guidance and Control (1998)

Abstract. This paper addresses the problem of in- tegrated design of guidance and control systems for au- tonomous vehicles (AVs). In fact, it introduces a new methodology for integrated design of guidance and control for such vehicles. The methodology proposed leads to an efficient procedure for the design of controllers for AVs to accurately track reference trajectories defined in an iner- tia! reference frame. The paper illustrates the application of this procedure on the design of a tracking controller for the Unmanned Air Vehicle Bluebird. The design phase is summarized, and the performance of the resulting con- troller is assessed in simulation using dynamic models of the vehicle and its sensor suite.
Identification Of Five Novel Human Papillomavirus Sequences In The New Mexico Triethnic Population (1994)

Cervical specimens obtained from previous clinical studies at the University of New Mexico were screened for reference strain human papillomaviruses (HPVs) via HPV L1 consensus polymerase chain reaction (PCR) and type-specific oligonucleotide probe hybridization. PCR products that bound to an HPV generic probe but did not hybridize with HPV type-specific oligonucleotide probes were subjected to restriction endonuclease digestion analyses. Resulting restriction fragment length polymorphisms served as the basis for initial grouping of unknown HPVs and identification of potential reference strain HPV variants. MY09/MY11 PCR products containing putative novel HPV L1 fragments were cloned and sequenced. Five novel HPV sequences were identified in this study.
An instrument for the measurement of large alternating currents (1944)

An arrangement of the measurement and oscillographic recording of large alternating currents, consisting of a special air-core transformer and an amplifier, is described. The air-core transformer is wound on a flexible core of small cross section, permitting its easy linkage with the current to be measured without disturbing the circuit. The underlying theory of the air-core transformer is discussed, and the modifications necessary to make it suitable for measurement purposes are described.
Myeloperoxidase and elastase are only expressed by neutrophils in normal and in inflammed liver (2011)

Myeloperoxidase (MPO) is involved in acute and chronic inflammatory diseases. The source of MPO in acute liver diseases is still a matter of debate. Therefore, we analysed MPO-gene expression on sections from normal and acutely damaged [carbon tetrachloride-(CCl(4)) or whole liver γ-Irradiation] rat liver by immunohistochemistry, real time PCR and Western blot analysis of total RNA and protein. Also total RNA and protein from isolated Kupffer cells, hepatic stellate cells, Hepatocytes, endothelial cells and neutrophil granulocytes (NG) was analysed by real time PCR and Western blot, respectively. Sections of acutely injured human liver were prepared for MPO and CD68 immunofluorescence double staining. In normal rat liver MPO was detected immunohistochemically and by immunofluorescence double staining only in single NG. No MPO was detected in isolated parenchymal and non-parenchymal cell populations of the normal rat liver. In acutely damaged rat liver mRNA of MPO increased 2.8-fold at 24 h after administration of CCl(4) and 3.3-fold at 3 h after γ-Irradiation and MPO was detected by immunofluorescence double staining only in elastase (NE) positive NGs but not in macrophages (ED1 or CD68 positive cells). Our results demonstrate that, increased expression of MPO in damaged rat and human liver is due to recruited elastase positive NGs.
Scavenging free radical with thirty-one species of Antimicrobial Chinese herb medicines in aquiculture (2005)

The antioxygenic activities of the ethanol extractions of 31 kinds of antimicrobial Chinese herb medicines were measured by DPPH method. The results show that three species in them (Anemarrhena asphodeloides Bunge, Pulsatilla chinensis (Bunge)Regel and Rhus chinensis Mill) possess high antioxygenic activities, compared with the Tea polyphenols.
Megakaryocytes of human immunodeficiency virus-infected individuals express viral RNA. (1989)

The pathogenesis of thrombocytopenia associated with human immunodeficiency virus (HIV) infection is not fully understood. Immune mechanisms provide a partial explanation but fail to account for a lack of compensatory megakaryocytosis, the rapid reversal after treatment with azidothymidine, and the ultrastructural aberrations seen in the megakaryocytes of patients with acquired immunodeficiency syndrome. Therefore, a direct effect of HIV on megakaryocytes was investigated. The bone marrow of HIV seropositive individuals was analyzed ultrastructurally, and the megakaryocytes of 10 thrombocytopenic patients were subjected to in situ hybridization with a HIV RNA probe. The structural aberrations in HIV megakaryocytes were distinct from those in HIV-negative immune thrombocytopenias, and the megakaryocytes of 10 of 10 patients examined by in situ hybridization unambiguously expressed viral RNA. Therefore, it is likely that direct infection of megakaryocytes with HIV-1 is one mechanism for the decrease in platelet production.
Hypocholesteremic activity of Cow urine ark and Aloe vera in poultry. (2014)

A study was conducted to assess out the hypocholeseteremic activity of Cow urine ark and Aloe vera extract in broilers. A significant decrease was observed in serum cholesterol, triglycerides, total lipids, LDL and VLDL. Significant increase was reported in HDL levels. The study reveals that Cow urine and Aloe vera extract has marked hypolipidemic activity.
Complex Geological Modeling and Quality Assurance Using Unstructured Grids (2018)

Abstract Conceptual limitations of existing gridding technologies often lead to undesirable simplifications to the modeling of structurally complex areas, and consequently poor predictions. We present a structural modeling and gridding workflow that limits these modeling compromises. A volume-based 3D structural model based on fault and horizon surfaces is constructed from input data that has undergone basic quality checking using a variety of techniques. The critical step in the grid creation is the definition of a flattened (‘depositional’) space that deforms the structural model mesh under mechanical constraints. A 3D ‘unstructured’ grid is created in the depositional space, based on ‘cutting’ a property-populated, regular cuboidal grid by the geological discontinuities. The tectonic consistency and better preservation of geodetic distance make the flattened space ideal for a range of property modeling approaches. The forward-deformation of the grid into true geological space tends to preserve the layer-orthogonality of the grid columns and makes the grid more suited to numerical simulation approximations. The final grid is unstructured, high quality and an accurate representation of the input structural model. The 3D structural model, depositional space transform and grid geometries all provide valuable information on the structural quality of the input data. The stretching and deforming of the orthogonal local axes in the transformation from depositional space to geological space are used to focus further effort on structural model quality assurance (QA). The key step in generating accurate property population and simulation models is the application of QA metrics on the grid geometry; the transformation from depositional space to geological space is used to generate a set of grid properties that highlight potential structural inconsistencies or data quality issues back in the structural model. We present several examples based on a range of structurally complex models, and demonstrate the downstream impact of applying this QA workflow throughout the stages of input data validation, structural model creation and grid creation.
A Reanalysis of IgM Western Blot Criteria for the Diagnosis of Early Lyme Disease (1999)

A two-step approach for diagnosis of Lyme disease, consisting of an initial EIA followed by a confirmatory Western immunoblot, has been advised by the Centers for Disease Control and Prevention (CDC). However, these criteria do not examine the influence of the prior probability of Lyme disease in a given patient on the predictive value of the tests. By using Bayesian analysis, a mathematical algorithm is proposed that computes the probability that a given patient's Western blot result represents Lyme disease. Assuming prior probabilities of early Lyme disease of 1%-10%, the current CDC minimum criteria for IgM immunoblot interpretation yield posttest probabilities of 4%-32%. The value of the two-step approach for diagnosis of early Lyme disease may be limited in populations at lower risk of disease or when patients present with atypical signs and symptoms.
Importance of animal models in schizophrenia research (2005)

Objective: This review aims to summarize the importance of animal models for research on psychiatric illnesses, particularly schizophrenia.Method and Results: Several aspects of animal models are addressed, including animal experimentation ethics and theoretical considerations of different aspects of validity of animal models. A more specific discussion is included on two of the most widely used behavioural models, psychotropic drug-induced locomotor hyperactivity and prepulse inhibition, followed by comments on the difficulty of modelling negative symptoms of schizophrenia. Furthermore, we emphasize the impact of new developments in molecular biology and the generation of genetically modified mice, which have generated the concept of behavioural phenotyping.Conclusions: Complex psychiatric illnesses, such as schizophrenia, cannot be exactly reproduced in species such as rats and mice. Nevertheless, by providing new information on the role of neurotransmitter systems and genes in behavioural function, animal ‘models’ can be an important tool in unravelling mechanisms involved in the symptoms and development of such illnesses, alongside approaches such as post-mortem studies, cognitive and psychophysiological studies, imaging and epidemiology.
The Cheshire Profession (1993)

No AccessAmerican Journal of AudiologyViewpoint1 Nov 1993The Cheshire Profession Aaron ThorntonPhD Aaron Thornton Audiology, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114-3096 Google Scholar More articles by this author https://doi.org/10.1044/1059-0889.0203.05 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationTrack Citations ShareFacebookTwitterLinked In "The Cheshire Profession." American Journal of Audiology, 2(3), p. 5 Additional Resources FiguresReferencesRelatedDetails Volume 2Issue 3November 1993Pages: 5-5 Get Permissions Add to your Mendeley library History Published in issue: Nov 1, 1993 Metrics Topicsasha-topicsleader-topicsasha-article-typesKeywordstechniciansAuDtrainingaudiologistCopyright & PermissionsCopyright © 1993 American Speech-Language-Hearing AssociationLoading ...
Aphid Alarm Pheromones: Secretion and Reception1 (1973)

Journal Article Aphid Alarm Pheromones: Secretion and Reception Get access L. R. Nault, L. R. Nault Search for other works by this author on: Oxford Academic PubMed Google Scholar L. J. Edwards, L. J. Edwards Search for other works by this author on: Oxford Academic PubMed Google Scholar W. E. Styer W. E. Styer Search for other works by this author on: Oxford Academic PubMed Google Scholar Environmental Entomology, Volume 2, Issue 1, 1 February 1973, Pages 101–105, https://doi.org/10.1093/ee/2.1.101 Published: 01 February 1973 Article history Received: 29 August 1972 Published: 01 February 1973
Optimal pulse durations for the treatment of leg telangiectasias with a neodymium YAG laser (2005)

Compared to shorter pulses (<20 milliseconds), longer pulses may provide gentler heating of the vessel and a greater ratio of contraction to thrombosis.
A novel orvinol analog, BU08028, as a safe opioid analgesic without abuse liability in primates (2016)

Significance A potent opioid analgesic without addictive and respiratory adverse effects has been a predominant goal for opioid medicinal chemistry since the isolation of morphine from opium in the 19th century. Here we report a functional profile of a unique analog, BU08028, targeting a combination of a classical and nonclassical opioid receptors in monkeys. By examining behavioral, physiological, and pharmacologic factors, the present study demonstrates that BU08028 exhibits full antinociception and antihypersensitivity without reinforcing effects (i.e., abuse liability), respiratory depression, pruritus, adverse cardiovascular events, or acute physical dependence. Because monkey models provide the most phylogenetically appropriate evaluation of opioid receptor functions and drug effects, these findings provide a translational bridge for such ligands as effective analgesics without safety and abuse liability concerns.
Protein Uptake and Digestion in Bloodstream and Culture Forms of <i>Trypanosoma brucei</i>* (1975)

The mechanisms of ferritin uptake and digestion differ in bloodstream and culture forms of Trypanosoma brucei. Ferritin enters bloodstream forms from the flagellar pocket by pinocytosis in large spiny-coated vesicles. These vesicles become continuous with straight tubular extensions of a complex, mostly tubular, collecting membrane membrane system where ferritin is concentrated. From the collecting membrane system the tracer enters large digestive vacuoles. Small spiny-coated vesicles, which never contain ferritin, are found in the Golgi region, fusing with the collecting membrane system, and around the flagellar pocket. Acid phosphatase activity is present in some small spiny-coated vesicles which may represent primary lysosomes. This enzymic activity is also found in the flagellar pocket, pinocytotic vesicles, the collecting membrane system, the Golgi (mature face), and digestive vacuoles of bloodstream forms. About 50 percent of the acid phosphatase activity of blood forms is latent. The remaining nonlatent activity is firmly cell-associated and probably represents activity in the flagellar pocket. The structures involved in ferritin uptake and digestion are larger and more active in the short stumpy than in the long slender bloodstream forms. The short stumpy forms also have more autophagic vacuoles. No pinocytotic large, spiny-coated vesicles or Golgi-derived, small spiny-coated vesicles are seen in culture forms. Ferritin leaves the flagellar pocket of these forms and enters small smooth cisternae located just beneath bulges in the pocket membrane. The tracer then passes through a cisternal collecting membrane network, where it is concentrated, and then into multivesicular bodies. In the culture forms, acid phosphatase activity is localized in the cisternal system, multivesicular bodies, the Golgi (mature face), and small vesicles in the Golgi and cisternal regions. The flagellar pocket has no acid phosphatase activity, and almost all the acitvity is latent in these forms. The culture forms do not release acid phosphatase into culture medium during 4 days growth. Uptake of ferritin by all forms is almost completely inhibited by low temperature. These differences among the long slender and short stumpy bloodstream forms and culture forms are undoubtedly adaptive and reflect different needs of the parasite in different life cycle stages.