gebhart/patrepeval huggingface dataset:
Splash 2 (1992)

Article Free Access Share on Splash 2 Authors: Jeffrey M. Arnold View Profile , Duncan A. Buell View Profile , Elaine G. Davis View Profile Authors Info & Claims SPAA '92: Proceedings of the fourth annual ACM symposium on Parallel algorithms and architecturesJune 1992Pages 316–322https://doi.org/10.1145/140901.141896Published:01 June 1992Publication History 103citation663DownloadsMetricsTotal Citations103Total Downloads663Last 12 Months57Last 6 weeks9 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Effects of Pressure on Resistance to Freezing and Thawing of Fiber-Reinforced Cement Board (2003)

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Fluoride ion catalyzed aldol reaction between enol silyl ethers and carbonyl compounds (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFluoride ion catalyzed aldol reaction between enol silyl ethers and carbonyl compoundsR. Noyori, K. Yokoyama, J. Sakata, Isao Kuwajima, Eiichi Nakamura, and Makoto ShimizuCite this: J. Am. Chem. Soc. 1977, 99, 4, 1265–1267Publication Date (Print):February 1, 1977Publication History Published online1 May 2002Published inissue 1 February 1977https://pubs.acs.org/doi/10.1021/ja00446a049https://doi.org/10.1021/ja00446a049research-articleACS PublicationsRequest reuse permissionsArticle Views1192Altmetric-Citations151LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Current Status Of Endovascular Repair Of Thoracic Aortic Aneurysms (TEVAR) (2011)

Thoracic endovascular aortic repair (TEVAR) has been one of the most important advances in the management of thoracic aortic disease in the past two decades. The procedure was originally developed by Dake and colleagues in 1994 for the treatment of descending thoracic aortic aneurysm (DTAA), using the same principles as EVAR for the treatment of abdominal aortic aneurysm (AAA). The first device approved for this indication was the TAG device (W.L. Gore & Associated, Inc., Flagstaff, AZ) in 2005. Since then there has been a plethora of changes and new developments related to thoracic endovascular aortic repair. This article will summarize the major updates related to TEVAR, focusing on three main aspects: what is new in device technology and future prospects; the expanding indications of TEVAR for the treatment of other pathologies and the newly developed techniques involved; and a glimpse at the expected future direction in the field.
The Application of RAROC Based on the Supervision in an Inverted Cycle in Economical Capital Allocation of Insurance Companies in China (2012)

金融危机过后,监管机构开始重视逆周期监管。逆周期监管主要有资本类监管、风险类监管、机制类监管和杠杆类监管机制,本文主要从资本类监管机制出发来分析保险公司的资本配置。经济资本作为一种风险和财务相融合的资本概念,经济资本可以广泛地应用于内部资本充足率管理和价值创造管理,为保险公司的关键决策提供依据尤其值得我们进行研究。但是经济资本具有一定的亲周期性,本文将RAROC引入保险公司经济资本的配置中,分析了应怎样进行经济资本的配置减少经济资本的亲周期性。
Nonlinear compression to sub-30-fs, 05  mJ pulses at 135  W of average power (2013)

Incorporation of coherent combination into a state-of-the-art fiber-chirped pulse amplification system obtains 1.1 mJ, 340 fs pulses with up to 280 W of average power at 250 kHz repetition rate. Propagation of this laser pulse inside a krypton-filled hollow-core fiber results in significant spectral broadening. Chirped mirrors are used to compress the pulses to 26 fs, 540 μJ (135 W) leading to a peak power of more than 11 GW. This unprecedented combination of high peak and average power ultrashort pulses opens up new possibilities in multidimensional surface science and coherent soft x-ray generation.
Comprehensive process monitoring for laser welding process optimization (2016)

Fundamental process monitoring is very helpful to detect defects formed during the complex interactions of capillary laser welding process. Beside the monitoring and diagnostics of laser welding process enlarges the process knowledge which is essential to prevent weld defects. Various studies on monitoring of laser welding processes of aluminum, copper and steel were performed. Coaxial analyses in real-time with inline coherent imaging and photodiode based measurements have been applied as well as off-axis thermography, spectroscopy, online X-Ray observation and highspeed imaging with 808 nm illumination wavelength. The presented diagnostics and monitoring methods were appropriate to study typical weld defects like pores, spatters and cracks. Using these diagnostics allows understanding the formation of such defects and developing strategies to prevent them.
Synthesis of a Novel Angiotensin II Receptor Antagonist Olmesartan Medoxomil (2005)

In this paper, a new angiotensin Ⅱ receptor antagonist, (5-methyl-2-oxo-1,3-dioxol-4-yl) methyl-4-(1-hydroxy-1-methylethyl)-2-propyl-1-[(2′-1H-tetrazol-5-yl-biphenyl-4-yl) methyl] imdazole-5-carboxylate(Olmesartan medoxomil), was synthesized using tartaric acid as starting material via nitration, cyclization, esterifcation, Grignard reaction, N-alkylation, hydrolyzation, O-alkylation and N-deprotection in 32.7% overall yield. The structure of title compound has been characterized by MS(mass spectrum), (()~1H)-NMR (nuclear magnetic resonance) and IR (ifrared spectrum). The condensation of 4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylic acid ethyl ester with 5-[4′-(bromomethyl) biphenyl-2-yl]-1-(triphenylmethyl) tetrazole by means of potassium hydroxide in DMF, instead of potassium tert-butoxide in dimethylacetamide or sodium hydroxide in DMF, gives the corresponding N-alkylated product, which is hydrolyzed with sodium hydroxide, instead of lithium hydroxide, in dioxane-water to the desired acid. The improved process is more practical.
<i>Drosophila</i> PDZ-GEF, a Guanine Nucleotide Exchange Factor for Rap1 GTPase, Reveals a Novel Upstream Regulatory Mechanism in the Mitogen-Activated Protein Kinase Signaling Pathway (2002)

PDZ-GEF is a novel guanine nucleotide exchange factor for Rap1 GTPase. Here we isolated Drosophila melanogaster PDZ-GEF (dPDZ-GEF), which contains the all-conserved domains of mammalian and nematode PDZ-GEF including cyclic nucleotide monophosphate-binding, Ras exchange motif, PDZ, RA, and GEF domains. dPDZ-GEF loss-of-function mutants were defective in the development of various organs including eye, wing, and ovary. Many of these phenotypes are strikingly similar to the phenotype of the rolled mutant, implying that dPDZ-GEF functions upstream of the mitogen-activated protein (MAP) kinase pathway. Indeed, we found that dPDZ-GEF is specifically involved in photoreceptor cell differentiation, facilitating its neuronal fate via activation of the MAP kinase pathway. Rap1 was found to link dPDZ-GEF to the MAP kinase pathway; however, Ras was not involved in the regulation of the MAP kinase pathway by dPDZ-GEF and actually had an inhibitory function. The analyses of ovary development in dPDZ-GEF-deficient mutants also demonstrated another role of dPDZ-GEF independent of the MAP kinase signaling pathway. Collectively, our findings identify dPDZ-GEF as a novel upstream regulator of various morphogenetic pathways and demonstrate the presence of a novel, Ras-independent mechanism for activating the MAP kinase signaling pathway.
Data tagging architecture for system monitoring in dynamic environments (2008)

Large enterprise systems need continuous monitoring at infrastructure, application and business levels to detect and prevent problem situations. Traditionally, automated monitoring solutions are programmed once at setup based on a set of well-defined monitoring objectives and handed over to the operations team. Such solutions have underlying data models that are often complex and semantically rich but in stable environments, this complexity is generally hidden from the operations team, who only need to make minor configuration changes (e.g. setting thresholds) as and when required. However, the situation is now rapidly changing with enterprise data centers being subject to continuous transformations as new software, hardware and process components get deployed or updated. This puts an immense burden on monitoring activity because not only thousands of different parameters need to get monitored but the addition and modification of service level objectives (SLOs) may happen continuously. We describe a monitoring system architecture which simplifies the task of authoring and managing SLOs in such dynamic and heterogeneous environments. At the heart of our approach is a lightweight and extensible data model that is derived from more complex configuration models, so as to only expose data relevant for monitoring to the operations team. Simple string-tags derived from this model are then used to label SLOs and associated data streams. The approach localizes programming to the data-sensor layer and makes authoring simpler than the specification of objects in an alternate richer but complex object-oriented representation. We also describe a tag-driven real-time visualization tool that can organize data streams using their accompanying tags and ease user navigation through large volumes of monitoring data.
Effectiveness of a Mobile Short-Message-Service–Based Disease Outbreak Alert System in Kenya (2016)

We conducted a randomized, controlled trial to test the effectiveness of a text-messaging system used for notification of disease outbreaks in Kenya. Health facilities that used the system had more timely notifications than those that did not (19.2% vs. 2.6%), indicating that technology can enhance disease surveillance in resource-limited settings.
TOE-OPAL-system vs. conductance measurements during inflow occlusion (2002)

s: European Association of Cardiothoracic Anaesthesiologists; 17th Annual Meeting; Dublin, Ireland; June 12-15, 2002: Measurement
Inhibition of Fibrocyte Differentiation by Serum Amyloid P (2003)

Wound healing and the dysregulated events leading to fibrosis both involve the proliferation and differentiation of fibroblasts and the deposition of extracellular matrix. Whether these fibroblasts are locally derived or from a circulating precursor population is unclear. Fibrocytes are a distinct population of fibroblast-like cells derived from peripheral blood monocytes that enter sites of tissue injury to promote angiogenesis and wound healing. We have found that CD14(+) peripheral blood monocytes cultured in the absence of serum or plasma differentiate into fibrocytes within 72 h. We purified the factor in serum and plasma that prevents the rapid appearance of fibrocytes, and identified it as serum amyloid P (SAP). Purified SAP inhibits fibrocyte differentiation at levels similar to those found in plasma, while depleting SAP reduces the ability of plasma to inhibit fibrocyte differentiation. Compared with sera from healthy individuals and patients with rheumatoid arthritis, sera from patients with scleroderma and mixed connective tissue disease, two systemic fibrotic diseases, were less able to inhibit fibrocyte differentiation in vitro and had correspondingly lower serum levels of SAP. These results suggest that low levels of SAP may thus augment pathological processes leading to fibrosis. These data also suggest mechanisms to inhibit fibrosis in chronic inflammatory conditions, or conversely to promote wound healing.
Development of a quantitative mass spectrometry multi-attribute method for characterization, quality control testing and disposition of biologics (2015)

Regulatory agencies have recently recommended a Quality by Design (QbD) approach for the manufacturing of therapeutic molecules. A QbD strategy requires deep understanding at the molecular level of the attributes that are crucial for safety and efficacy and for insuring that the desired quality of the purified protein drug product is met at the end of the manufacturing process. A mass spectrometry (MS)-based approach to simultaneously monitor the extensive array of product quality attributes (PQAs) present on therapeutic molecules has been developed. This multi-attribute method (MAM) uses a combination of high mass accuracy / high resolution MS data generated by Orbitrap technology and automated identification and relative quantification of PQAs with dedicated software (Pinpoint). The MAM has the potential to replace several conventional electrophoretic and chromatographic methods currently used in Quality Control to release therapeutic molecules. The MAM represents an optimized analytical solution to focus on the attributes of the therapeutic molecule essential for function and implement QbD principles across process development, manufacturing and drug disposition.
X509.v3 certificate extension for authorization of device ownership (2015)

This document details an X.509 extension to provide authorization and
indication of ownership of a constrained device containing 802.1AR
IDevID.
Mobile OGSI.NET: grid computing on mobile devices (2004)

The problem with the grid is that it does not currently extend completely to devices, because these devices are not viewed as having sufficient capability to be both clients and services. We design, implement and evaluate Mobile OGSI.NET, which extends an implementation of grid computing, OGSI.NET, to mobile devices. Mobile OGSI.NET addresses the mobile devices' resource limitations and intermittent network connectivity, factors which differentiate them from traditional computers. Because Mobile OGSI.NET uniquely supports the hosting of grid services on the device, Mobile OGSI.NET is an important step toward making the mobile device a first-class entity in grids based on OGSI or the Web Services Resource Framework (WSRF).
Quantum Information: Long Distance Quantum Teleportation (2003)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text N. Gisin, I. Marcikic, H. de Riedmatten, W. Tittel, and H. Zbinden, "Quantum Information: Long Distance Quantum Teleportation," Optics & Photonics News 14(12), 39-39 (2003) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
A comparison of reflection and refraction processing and interpretation methods applied to conventional refraction data from coastal Maine (1987)

Abstract In 1984 the U.S. Geological Society collected 850 km of refraction data in lines parallel and perpendicular to regional strike of the Appalachian orogen in Maine and southeastern Quebec. A 100-km-long strike-line in coastal Maine, west of Penobscot Bay, is here interpreted on the basis of both refracted and reflected phases. Techniques used in seismic reflection processing, including normal movement velocity corrections and common mid-point stacking, were applied to the refraction data in order to enhance the visibility of reflected phases. The geometries of the most laterally continuous reflections as defined by these techniques can be correlated with reflections seen on a crossing, near-vertical reflection profile. Conventional ray-tracing analysis of refracted and wide-angle reflected phases in the refraction data constrains the velocity structure to about 14 km depth, and provides evidence for high-veiocity material (>6.5 km/sec) between 4 and 7 km depth, and for lower velocities (
PubChem Substance and Compound databases (2015)

PubChem (https://pubchem.ncbi.nlm.nih.gov) is a public repository for information on chemical substances and their biological activities, launched in 2004 as a component of the Molecular Libraries Roadmap Initiatives of the US National Institutes of Health (NIH). For the past 11 years, PubChem has grown to a sizable system, serving as a chemical information resource for the scientific research community. PubChem consists of three inter-linked databases, Substance, Compound and BioAssay. The Substance database contains chemical information deposited by individual data contributors to PubChem, and the Compound database stores unique chemical structures extracted from the Substance database. Biological activity data of chemical substances tested in assay experiments are contained in the BioAssay database. This paper provides an overview of the PubChem Substance and Compound databases, including data sources and contents, data organization, data submission using PubChem Upload, chemical structure standardization, web-based interfaces for textual and non-textual searches, and programmatic access. It also gives a brief description of PubChem3D, a resource derived from theoretical three-dimensional structures of compounds in PubChem, as well as PubChemRDF, Resource Description Framework (RDF)-formatted PubChem data for data sharing, analysis and integration with information contained in other databases.
Microsatellite Tandem Repeats Are Abundant in Human Promoters and Are Associated with Regulatory Elements (2013)

Tandem repeats are genomic elements that are prone to changes in repeat number and are thus often polymorphic. These sequences are found at a high density at the start of human genes, in the gene's promoter. Increasing empirical evidence suggests that length variation in these tandem repeats can affect gene regulation. One class of tandem repeats, known as microsatellites, rapidly alter in repeat number. Some of the genetic variation induced by microsatellites is known to result in phenotypic variation. Recently, our group developed a novel method for measuring the evolutionary conservation of microsatellites, and with it we discovered that human microsatellites near transcription start sites are often highly conserved. In this study, we examined the properties of microsatellites found in promoters. We found a high density of microsatellites at the start of genes. We showed that microsatellites are statistically associated with promoters using a wavelet analysis, which allowed us to test for associations on multiple scales and to control for other promoter related elements. Because promoter microsatellites tend to be G/C rich, we hypothesized that G/C rich regulatory elements may drive the association between microsatellites and promoters. Our results indicate that CpG islands, G-quadruplexes (G4) and untranslated regulatory regions have highly significant associations with microsatellites, but controlling for these elements in the analysis does not remove the association between microsatellites and promoters. Due to their intrinsic lability and their overlap with predicted functional elements, these results suggest that many promoter microsatellites have the potential to affect human phenotypes by generating mutations in regulatory elements, which may ultimately result in disease. We discuss the potential functions of human promoter microsatellites in this context.
Heterocycles from substituted amides. VIII Oxazole derivatives from reaction of isocyanates with 2‐isocyanoacetamides (1980)

Abstract A facile reaction of 2‐isocyanoacetamides 1 with reactive aryl and sulfonyl isocyanates is shown to give 5‐amino‐2‐oxazolecarboxamides 3 in a reaction arising from electrophilic attack of isocyanate with the nucleophilic isocyanide carbon. This reaction, perhaps proceeding through an unstable nitrile ylid intermediate reminiscent of the Cornforth rearrangement, is a first example of ring closure via acylation, involving the activated methylene of an organic isocyanide, without recourse to added base. Isomeric 5‐amino‐4‐oxazolecarboxamides 4 are formed when 5‐aminooxazoles 2 react with isocyanates. Since 2 has previously been shown to easily form by thermal isomerization of 1 , methods now exist for the preparation of both 5‐amino‐ 2‐ and 4‐oxazolecarboxamides from the single starting material 1 . In contrast, 1 with acyl isocyanates is shown to give a variety of products, including iminooxazolinediones, 5‐amino‐2‐oxazolecarbox‐amide 3 and 2 (1) pyrazinones (tentatively identified), depending on the structure of the isocyanates.
Oxidatively Truncated Phospholipids Are Required Agents of Tumor Necrosis Factor α (TNFα)-induced Apoptosis (2012)

TNFα generates reactive oxygen species (ROS) at the cell surface that induce cell death, but how ROS communicate to mitochondria and their specific apoptotic action(s) are both undefined. ROS oxidize phospholipids to hydroperoxides that are friable and fragment adjacent to the (hydro)peroxide function, forming truncated phospholipids, such as azelaoyl phosphatidylcholine (Az-PC). Az-PC is relatively soluble, and exogenous Az-PC rapidly enters cells to damage mitochondrial integrity and initiate intrinsic apoptosis. We determined whether this toxic phospholipid is formed within cells during TNFα stimulation in sufficient quantities to induce apoptosis and if they are essential in TNFα-induced cytotoxicity. We found that TNFα induced ROS formation and phospholipid peroxidation in Jurkat cells, and either chemical interference with NADPH oxidase activity or siRNA suppression of the NADPH oxidase-4 subunit blocked ROS accumulation and phospholipid peroxidation. Mass spectrometry showed that phospholipid peroxides and then Az-PC increased after TNFα exposure, whereas ROS inhibition abolished Az-PC accumulation and TNFα-induced cell death. Glutathione peroxidase-4 (GPx4), which specifically metabolizes lipid hydroperoxides, fell in TNFα-stimulated cells prior to death. Ectopic GPx4 overcame this, reduced peroxidized phospholipid accumulation, blocked Az-PC accumulation, and prevented death. Conversely, GPx4 siRNA knockdown enhanced phospholipid peroxidation, increasing TNFα-stimulated Az-PC formation and apoptosis. Truncated phospholipids were essential elements of TNFα-induced apoptosis because overexpression of PAFAH2 (a phospholipase A(2) that selectively hydrolyzes truncated phospholipids) blocked TNFα-induced Az-PC accumulation without affecting phospholipid peroxidation. PAFAH2 also abolished apoptosis. Thus, phospholipid oxidation and truncation to apoptotic phospholipids comprise an essential element connecting TNFα receptor signaling to mitochondrial damage and apoptotic death.