gebhart/patrepeval huggingface dataset:
Inhibitory effect of melatonin on production of IFNγ or TNFα in peripheral blood mononuclear cells of some blood donors (1994)

Melatonin, the main pineal hormone, has been shown to influence many biological functions, including the immune response and cancer growth. The purpose of this study was to examine the effect of melatonin on the production of interferon gamma (IFN gamma) and tumor necrosis factor alpha (TNF alpha) by peripheral blood mononuclear cells (PBMC) in culture. Melatonin at physiological concentrations fails to induce production of IFN or TNF by PBMC in culture but causes a dose-related inhibition of production of both cytokines if the PBMC are stimulated with phytohaemagglutinin. This inhibitory effect occurs in only 22% of cases (melatonin-sensitive) but disappears when the cells are stored at 4 degrees C for 4 days. The effect of melatonin appears not to be mediated by opiates nor to be correlated with the age, sex, or blood group of donors, but seems to be influenced by the seasonal time of blood collection. These results provide further evidence for an interaction between melatonin and the immune system and suggest that the effect of melatonin on production of IFN and TNF may be mediated by various factors not yet fully understood.
Super‐resolution microscopy by movable thin‐films with embedded microspheres: Resolution analysis (2015)

Microsphere‐assisted imaging has emerged as an extraordinary simple technique of obtaining optical super‐resolution. This work addresses two central problems in developing this technology: i) methodology of the resolution measurements and ii) limited field‐of‐view provided by each sphere. It is suggested that a standard method of resolution analysis in far‐field microscopy based on convolution with the point‐spread function can be extended into the super‐resolution area. This allows developing a unified approach to resolution measurements, which can be used for comparing results obtained by different techniques. To develop the surface scanning functionality, the high‐index ( n ∼ 2) barium titanate glass microspheres were embedded in polydimethylsiloxane (PDMS) thin‐films. It is shown that such films adhere to the surface of nanoplasmonic structures so that the tips of embedded spheres experience the objects’ optical near‐fields. Based on rigorous criteria, the resolution ∼ λ /6‐ λ /7 (where λ is the illumination wavelength) is demonstrated for arrays of Au dimers and bowties. Such films can be translated along the surface of investigated samples after liquid lubrication. It is shown that just after lubrication the resolution is diffraction limited, however the super‐resolution gradually recovers as the lubricant evaporates. image
A Viral Nuclear Noncoding RNA Binds Re-localized Poly(A) Binding Protein and Is Required for Late KSHV Gene Expression (2011)

During the lytic phase of infection, the gamma herpesvirus Kaposi's Sarcoma-Associated Herpesvirus (KSHV) expresses a highly abundant, 1.1 kb nuclear noncoding RNA of unknown function. We observe that this polyadenylated nuclear (PAN) RNA avidly binds host poly(A)-binding protein C1 (PABPC1), which normally functions in the cytoplasm to bind the poly(A) tails of mRNAs, regulating mRNA stability and translation efficiency. During the lytic phase of KSHV infection, PABPC1 is re-localized to the nucleus as a consequence of expression of the viral shutoff exonuclease (SOX) protein; SOX also mediates the host shutoff effect in which host mRNAs are downregulated while viral mRNAs are selectively expressed. We show that whereas PAN RNA is not required for the host shutoff effect or for PABPC1 re-localization, SOX strongly upregulates the levels of PAN RNA in transient transfection experiments. This upregulation is destroyed by the same SOX mutation that ablates the host shutoff effect and PABPC1 nuclear re-localization or by removal of the poly(A) tail of PAN. In cells induced into the KSHV lytic phase, depletion of PAN RNA using RNase H-targeting antisense oligonucleotides reveals that it is necessary for the production of late viral proteins from mRNAs that are themselves polyadenylated. Our results add to the repertoire of functions ascribed to long noncoding RNAs and suggest a mechanism of action for nuclear noncoding RNAs in gamma herpesvirus infection.
Rat prostatic binding protein: the complete sequence of the C2 gene and its flanking regions (1987)

The complete sequence (2879 bp) of the androgen-controlled rat prostatic binding protein C2 gene and 1023 bp of the 5'- and 2127 bp of the 3'-flanking regions have been determined. The gene contains three exons (93, 203 and 147 bp) and two introns (1630 and 806 bp). It is flanked by two homopurine-homopyrimidine stretches of 55 and 131 nucleotides respectively, located at positions -405 and 4151. These sequences are remarkably sensitive towards S1-nuclease, indicating an altered DNA conformation under superhelical stress. Several palindromes and dyad structures are observed in the 5'-upstream region of the gene and at position -457, and 80% homology to the consensus sequence of a glucocorticoid receptor binding site is found.
Learning to Deblur Images with Exemplars (2018)

Human faces are one interesting object class with numerous applications. While significant progress has been made in the generic deblurring problem, existing methods are less effective for blurry face images. The success of the state-of-the-art image deblurring algorithms stems mainly from implicit or explicit restoration of salient edges for kernel estimation. However, existing methods are less effective as only few edges can be restored from blurry face images for kernel estimation. In this paper, we address the problem of deblurring face images by exploiting facial structures. We propose a deblurring algorithm based on an exemplar dataset without using coarse-to-fine strategies or heuristic edge selections. In addition, we develop a convolutional neural network to restore sharp edges from blurry images for deblurring. Extensive experiments against the state-of-the-art methods demonstrate the effectiveness of the proposed algorithm for deblurring face images. In addition, we show that the proposed algorithms can be applied to image deblurring for other object classes.
Preparation of Enantiomerically Pure Tertiary Phosphine Oxides from, and Assay of Enantiomeric Purity with, (Rp)- and (Sp)-tert-Butylphenylphosphinothioic Acids (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation of Enantiomerically Pure Tertiary Phosphine Oxides from, and Assay of Enantiomeric Purity with, (Rp)- and (Sp)-tert-Butylphenylphosphinothioic AcidsRichard K. Haynes, Richard N. Freeman, Craig R. Mitchell, and Simone C. VonwillerCite this: J. Org. Chem. 1994, 59, 11, 2919–2921Publication Date (Print):June 1, 1994Publication History Published online1 May 2002Published inissue 1 June 1994https://pubs.acs.org/doi/10.1021/jo00090a003https://doi.org/10.1021/jo00090a003research-articleACS PublicationsRequest reuse permissionsArticle Views433Altmetric-Citations52LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Introduction (2016)

Distribution électronique Cairn.infopour Érès.Distribution électronique Cairn.infopour Érès.La reproduction ou représentation de cet article, notamment par photocopie, n'est autorisée que dans les limites des conditions générales d'utilisation du site ou, le cas échéant, des conditions générales de la licence souscrite par votre établissement.Toute autre reproduction ou représentation, en tout ou partie, sous quelque forme et de quelque manière que ce soit, est interdite sauf accord préalable et écrit de l'éditeur, en dehors des cas prévus par la législation en vigueur en France.Il est précisé que son stockage dans une base de données est également interdit.Article disponible en ligne à l'adresse Article disponible en ligne à l'adresse https://www.cairn.info/revue-spirale-2015-4-page-15.htmDécouvrir le sommaire de ce numéro, suivre la revue par email, s'abonner... Flashez ce QR Code pour accéder à la page de ce numéro sur Cairn.info.C'est avec un point de vue assez comparable que la plupart des auteurs réunis dans ce numéro de Spirale, qui sont tous aussi des chercheurs, décrivent le bébé.La connaissance, selon Varela, n'est pas l'accès à un système de représentations prédéterminées dans un environnement fixe et à la vérité unique, mais une connaissance qui prend appui sur l'action du sujet, ellemême guidée par des processus incarnés.Elle
New synthetic reactions. A chemoselective approach to cleavage .alpha. to a carbonyl group via .beta.-keto sulfides. Preparation of 1,2-diketones (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew synthetic reactions. A chemoselective approach to cleavage .alpha. to a carbonyl group via .beta.-keto sulfides. Preparation of 1,2-diketonesBarry M. Trost and Georges S. MassiotCite this: J. Am. Chem. Soc. 1977, 99, 13, 4405–4412Publication Date (Print):June 1, 1977Publication History Published online1 May 2002Published inissue 1 June 1977https://doi.org/10.1021/ja00455a032RIGHTS & PERMISSIONSArticle Views1011Altmetric-Citations106LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (917 KB) Get e-Alerts Get e-Alerts
News of the Profession (1994)

The Modern Records Centre of the University of Warwick Library in Coventry owes its existence to the foresight of a number of academics at this new university 1 in the early 1970s and the generosity of the Leverhulme Trust in responding to their proposals. However, even their foresight could scarcely have envisaged the situation reached by
Members of the Family <i>Comamonadaceae</i> as Primary Poly(3-Hydroxybutyrate-co-3-Hydroxyvalerate)-Degrading Denitrifiers in Activated Sludge as Revealed by a Polyphasic Approach (2002)

The distribution and phylogenetic affiliations of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV)-degrading denitrifying bacteria in activated sludge were studied by a polyphasic approach including culture-independent biomarker and molecular analyses as well as cultivation methods. A total of 23 strains of PHBV-degrading denitrifiers were isolated from activated sludges from different sewage treatment plants. 16S ribosomal DNA (rDNA) sequence comparisons showed that 20 of the isolates were identified as members of the family Comamonadaceae, a major group of beta-Proteobacteria. When the sludges from different plants were acclimated with PHBV under denitrifying conditions in laboratory scale reactors, the nitrate removal rate increased linearly during the first 4 weeks and reached 20 mg NO(3)(-)-N h(-1) g of dry sludge(-1) at the steady state. The bacterial-community change in the laboratory scale sludges during the acclimation was monitored by rRNA-targeted fluorescence in situ hybridization and quinone profiling. Both approaches showed that the population of beta-Proteobacteria in the laboratory sludges increased sharply during acclimation regardless of their origins. 16S rDNA clone libraries were constructed from two different acclimated sludges, and a total of 37 clones from the libraries were phylogenetically analyzed. Most of the 16S rDNA clones were grouped with members of the family Comamonadaceae. The results of our polyphasic approach indicate that beta-Proteobacteria, especially members of the family Comamonadaceae, are primary PHBV-degrading denitrifiers in activated sludge. Our data provide useful information for the development of a new nitrogen removal system with solid biopolymer as an electron donor.
A CAD model of triangular Split Ring Resonator based on equivalent circuit approach (2009)

In the recent decade, metamaterials have become one of the popular areas of interest. Some of the various structures of Split-Ring Resonators (SRR) we have come across are circular, square, spiral and omega shaped. All these structures produce effective permeability and permittivity as negative over a certain range of frequencies. In this paper, a new structure of triangular split ring resonator with edge-coupling is proposed. The structure consists of two equilateral concentric triangles made of metal with dielectric medium filled in the gaps. The advantage of this structure includes the reduction in size of the SRR and the wide range of resonant frequencies possible. The layout or the structure with the equivalent circuit and the Computer Aided Design model (CAD) design are presented. The variation of the resonant frequencies with respect to the conductor and dielectric width is also shown.
Primary structure of human fibrinogen and fibrin. Isolation and partial characterization of chains of fragment D. (1975)

Fragment D has been isolated as an apparently single molecular weight species (molecular weight about 100,000) from plasmin digests of humman fibrinogen, using a combination of affinity chromatography on insolubilized "fibrin monomer" and gel filtration. This fragment consists of three chains with molecular weights of 15,000 (Dbeta), 42,500 (Dgamma1) or 39,500 (Dgamma2), and 14,000 (Dalpha) held together by disulfide bonds. The S-carboxymethyl derivatives of the chains have been separated by gel filtration and ion exchange chromatography, and their identity has been confirmed by peptide mapping and immunological analysis. The chain with a molecular weight of 45,000 is a fragment of the Bbeta chain of fibrinogen. The chain derived from the gamma chain of fibrinogen occurred in two molecular forms having molecular weight 42,500 and 39,500. The chain derivative with molecular weight 14,000 is most likely derived from the Aalpha chain of fibrinogen. The chains were characterized by NH2-terminal sequence analysis, amino acid composition, and carbohydrate staining. The two molecular analysis, amino acid composition, and carbohydrate staining. The two molecular forms of the gamma chain appeared to be identical except for an NH2-terminal peptide extension of 23 amino acid residues in the longer chain. The latter has sequences in common with the COOH-terminal part of the gamma chain of the NH2-terminal disulfide knot (BROMBACK, B., BRONDAHL, N. J., HESSEL, B., IWANAGA, S., and WALLEN, P. (1973) J. Biol. Chem. 248, 5806-5820); its NH2-terminal residue being Ala-63 of the gamma chain of fibrinogen.
Apparent diffusion coefficients in the evaluation of high-grade cerebral gliomas. (2001)

As a group, ADC values helped to distinguish high-grade glioma from normal tissue but could not be used to separate high-grade glioma from surrounding edema. Individually, ADC values overlapped considerably and were not useful in our patients. The utility of ADC values (as obtained in this relatively small study) is questionable in patients with high-grade cerebral astrocytomas.
Synthetic Studies of Rifamycins. II. Syntheses of Methyl 2,4,6,7-Tetradeoxy-4-<i>C</i>-methyl-3-<i>O</i>-methyl-α-<scp>l</scp>-<i>arabino</i>-heptopyranosid-6-ulose and Its Derivatives Utilizable in the Construction of the Rifamycin Ansa Chain Portion (1980)

Abstract 3,6-Dideoxy-3-C-methyl-2-O-methyl-d-galactopyranose(12) was prepared in 10 steps from methyl 4,6-O-benzylidene-3-deoxy-3-C-methyl-α-d-altropyranoside. 12 was converted into 4,5-di-O-acetyl-3,6-dideoxy-3-C-methyl-2-O-methyl-d-galactose, which was then condenced in ether with (methoxymethylene)triphenylphosphorane (generated from the phosphonium salt with the dimethylsulfinylmethanide anion in ether) to produce 5,6-di-O-acetyl-2,4,7-trideoxy-4-C-methyl-1,3-di-O-methyl-d-galacto-1-enoheptitol (16). The treatment of 16 with NBS in methanol, followed by the debromination of the resulting 2-bromo aldehyde dimethyl acetal with tributylstannane, deacetylation, and mild methanolysis afforded methyl 2,4,7-trideoxy-4-C-methyl-3-O-methyl-β-d-galacto-heptopyranoside(19), which then provided the title compound 20 upon Jones oxidation. The potential intermediates, the 1-lithio-1-(methyl 2,4-dideoxy-4-C-methyl-3-O-methyl-α-l-arabino-pentopyranos-5-yl)ethene and (E)-2-(methyl 2,4-dideoxy-4-C-methyl-3-O-methyl-α-l-arabino-pentopyranos-5-yl)propenylcopper intermediates, were prepared from 20 via the corresponding alkenyl iodide and (methyl 2,4-dideoxy-4-C-methyl-3-O-methyl-α-l-arabino-pentopyranos-5-yl)ethyne and were demonstrated to condense with benzaldehyde and ethylene oxide respectively.
Waveguide bends in three-dimensional layer-by-layer photonic bandgap materials (1999)

We theoretically investigate waveguide bends in three-dimensional dielectric photonic bandgap (PBG) materials. The PBG materials used in this study consist of layers of alumina rods. An L-shaped waveguide is created by removing part of the rod in one layer and part of the rod in the next layer. The removed rods are perpendicular to each other. Using finite-difference time-domain (FDTD) simulations, we found that 100% transmission efficiency can be achieved through the 90° bend. ©1999 John Wiley & Sons, Inc. Microwave Opt Technol Lett 23: 56–59, 1999.
Circular photogalvanic effect on topological insulator surfaces: Berry curvature-dependent response (2011)

We study theoretically the optical response of the surface states of a topological insulator, especially the generation of helicity-dependent direct current by circularly polarized light. Interestingly, the dominant current, due to an interband transition, is controlled by the Berry curvature of the surface bands. This extends the connection between photocurrents and Berry curvature beyond the quasiclassical approximation, where it has been shown to hold. Explicit expressions are derived for the (111) surface of the topological insulator Bi${}_{2}$Se${}_{3}$, where we find significant helicity-dependent photocurrents when the rotational symmetry of the surface is broken by an in-plane magnetic field or a strain. Moreover, the dominant current grows linearly with time until a scattering occurs, which provides a means for determining the scattering time. The dc spin generated on the surface is also dominated by a linear-in-time, Berry curvature-dependent contribution.
Integrated Class-D Amplifier With Active Current Sensing Suitable for Alternating Current Switches (2008)

An integrated class-D amplifier with active current sensing suitable for AC switches is presented in this paper. The proposed current-sensing technique is used to sense and control the inductor current at the output stage and allows the current-sensing element to be integrated into class-D amplifiers. To verify the performance of the proposed circuits, a class-D amplifier was designed and fabricated with 3.3-V 0.35- mum double-polyquadruple-metal CMOS technology on a chip area of 1.79 times 1.45 mm. The maximum power efficiency of the class-D amplifier can be up to 94% for an 8-Omega load. These active current-sensing circuits can be applied to other power converters with AC switches.
The general and simplified Jones matrix representations for the high pretilt twisted nematic cell (1990)

A general Jones matrix representation for an arbitrary pretilt twisted nematic (TN) cell at any given applied voltage is obtained. A simplified Jones matrix representation for the high pretilt TN cell at the field-off state is derived from this general Jones matrix representation. The validity of this simplified representation is examined by comparing the optical transmission of a high pretilt angle TN cell, at the field-off state, as a function of the cell gap thickness obtained from this simplified representation with that obtained by the general representation. The result shows that the simplified Jones matrix representation for a TN cell at the field-off state works very well even for the pretilt angle as high as 30°. In addition, a property of the average tilt angle of a TN cell is reported.
T4 Endonuclease IV (1972)

An improved procedure for the purification of T4 endonuclease IV from T4+-infected Escherichia coli cells is described. The enzyme preparations are highly concentrated, free of exonuclease contamination, and display about 200-fold greater activity toward single stranded DNA than toward duplex DNA. The limit product obtained by exhaustive digestion of single stranded DNA with endonuclease IV is 25% acid-soluble and consists of oligonucleotides with an average chain length of about 50 nucleotides. The enzyme may be useful in sequencing DNA. A second endonuclease which exhibits a preference for denatured DNA was also purified from T4+-infected E. coli cells and was named T4 endonuclease III. This enzyme is clearly distinguishable from T4 endonuclease IV on the basis of its chromatographic behavior. Furthermore, endonuclease III is able to act on denatured T4 DNA, whereas endonuclease IV does not; endonuclease III does not produce appreciable acid-soluble material from polydeoxycytidylate, whereas endonuclease IV does; and endonuclease III produces oligonucleotides whose 5′-terminal mononucleotides are not specific, whereas the oligonucleotides produced by endonuclease IV end exclusively in 5′-dCMP.
A 25ns 1Mb CMOS SRAM (1987)

HIGH-SPEED OPERATION and low-power consumption are crucial requirements for the new generation high density SR.4kIs. This paper will describe development of a Mb chip with a typical address access time of 25ns and typical operating current of 15mA. Desired performance has been realized by bit-line circuitry (LOAF bit line), a 2-stage sense amplifier utilizing renewed double word-line structure, address transition detection techniques and a 0.8μm CMOS process with double-level polysilicon and double-level aluminum layers