gebhart/patrepeval huggingface dataset:
Filter assay for 1α,25-dihydroxyvitamin D<sub>3</sub>. Utilization of the hormone's target tissue chromatin receptor (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFilter assay for 1α,25-dihydroxyvitamin D3. Utilization of the hormone's target tissue chromatin receptorPeter F. Brumbaugh, David H. Haussler, Kristine M. Bursac, and Mark R. HausslerCite this: Biochemistry 1974, 13, 20, 4091–4097Publication Date (Print):September 1, 1974Publication History Published online1 May 2002Published inissue 1 September 1974https://doi.org/10.1021/bi00717a005Request reuse permissionsArticle Views52Altmetric-Citations128LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (823 KB) Get e-Alertsclose Get e-Alerts
Observations from a case study on user adaptive reminders for medication adherence (2008)

We present the design and exploratory evaluation of a sensor-driven adaptive reminder system for home medical tasks. Our prototype implementation consists of a mobile reminder delivery device and ambient sensors for determining opportune moments for reminder delivery. A volunteer used the prototype in a residential research facility while adhering to a regimen of simulated medical tasks for ten days. Based on this case study, including direct observation of individual alert-action sequences, we make four recommendations for designers of context-sensitive adaptive reminder systems.
The Hilsch Tube: Low-Pressure Effects (1961)

The Hilsch vortex tube was investigated at low operating pressures (gauge pressures less than one atmosphere). A mathematical analysis by Burkhardt was extended to include this pressure range. Except for differences in magnitude, the experimental results were essentially the same as those previously reported in the literature for high pressure tests. However, because of low flow rates, heat exchanges with the environment had a more pronounced effect. The dependence of Hilsch tube heating or cooling upon the specific heat ratio of the working gas was derived for low operating pressures. This result was experimentally verified for argon and air.
ChemInform Abstract: The “tert.‐Amino Effect” in Heterocyclic Chemistry: Synthesis of 3,1‐Benzoxazines and 3,1‐Benzothiazines. (1989)

Abstract The cyclization of tertiary anilines is known to show an unexpected reactivity, when a conjugated unsaturated ortho‐substituent in the aromatic ring is present.
Retronphage φR73: an <i>E. coli</i> Phage That Contains a Retroelement and Integrates Into a tRNA Gene (1991)

Some strains of Escherichia coli contain retroelements (retrons) that encode genes for reverse transcriptase and branched, multicopy, single-stranded DNA (msDNA) linked to RNA. However, the origin of retrons is unknown. A P4-like cryptic prophage was found that contains a retroelement (retron Ec73) for msDNA-Ec73 in an E. coli clinical strain. The entire genome of this prophage, named phi R73, is 12.7 kilobase pairs and is flanked by 29-base pair direct repeats derived from the 3' end of the selenocystyl transfer RNA gene (selC). P2 bacteriophage caused excision of the phi R73 prophage and acted as a helper to package phi R73 DNA into an infectious virion. The newly formed phi R73 closely resembled P4 as a virion and in its lytic growth. Retronphage phi R73 lysogenized a new host strain, reintegrating its genome into the selC gene of the host chromosome and enabling the newly formed lysogens to produce msDNA-Ec73. Hence, retron Ec73 can be transferred intercellularly as part of the genome of a helper-dependent retronphage.
Landmark classification in large-scale image collections (2009)

With the rise of photo-sharing websites such as Facebook and Flickr has come dramatic growth in the number of photographs online. Recent research in object recognition has used such sites as a source of image data, but the test images have been selected and labeled by hand, yielding relatively small validation sets. In this paper we study image classification on a much larger dataset of 30 million images, including nearly 2 million of which have been labeled into one of 500 categories. The dataset and categories are formed automatically from geotagged photos from Flickr, by looking for peaks in the spatial geotag distribution corresponding to frequently-photographed landmarks. We learn models for these landmarks with a multiclass support vector machine, using vector-quantized interest point descriptors as features. We also explore the non-visual information available on modern photo-sharing sites, showing that using textual tags and temporal constraints leads to significant improvements in classification rate. We find that in some cases image features alone yield comparable classification accuracy to using text tags as well as to the performance of human observers.
Bioactive Compounds Isolated from Microalgae in Chronic Inflammation and Cancer (2015)

The risk of onset of cancer is influenced by poorly controlled chronic inflammatory processes. Inflammatory diseases related to cancer development include inflammatory bowel disease, which can lead to colon cancer, or actinic keratosis, associated with chronic exposure to ultraviolet light, which can progress to squamous cell carcinoma. Chronic inflammatory states expose these patients to a number of signals with tumorigenic effects, including nuclear factor kappa B (NF-κB) and mitogen-activated protein kinases (MAPK) activation, pro-inflammatory cytokines and prostaglandins release and ROS production. In addition, the participation of inflammasomes, autophagy and sirtuins has been demonstrated in pathological processes such as inflammation and cancer. Chemoprevention consists in the use of drugs, vitamins, or nutritional supplements to reduce the risk of developing or having a recurrence of cancer. Numerous in vitro and animal studies have established the potential colon and skin cancer chemopreventive properties of substances from marine environment, including microalgae species and their products (carotenoids, fatty acids, glycolipids, polysaccharides and proteins). This review summarizes the main mechanisms of actions of these compounds in the chemoprevention of these cancers. These actions include suppression of cell proliferation, induction of apoptosis, stimulation of antimetastatic and antiangiogenic responses and increased antioxidant and anti-inflammatory activity.
The endocannabinoid system and the treatment of obesity (2005)

The endocannabinoids are endogenous lipids capable of binding to both cannabinoid receptors (CB) CB1 and CB2. These receptors belong to the G protein-coupled family receptors and they were discovered while investigating the mode of action of ?(9)-tetrahydrocannabinol, a component of Cannabis sativa, to which they bind with high affinity. Among many other brain sites, CB1 is present in the hypothalamic nuclei involved in the control of energy balance and body weight, as well as in neurons of the mesolimbic system which is believed to mediate the incentive value of food. At central nervous system level, CB1 activation is necessary to induce food intake after a short period of food deprivation, and when CB1 is activated by endocannabinoids produced in situ, a stimulation of the ingestion of palatable food has been described. CB1 stimulation leads to modulation of the release of some hypothalamic anorexigenic and orexigenic mediators, as well as of dopamine in the nucleus accumbens shell. Recent evidence has proved that CB1 is also present in the peripheral organs, such as the adipose tissue and gastrointestinal system, key organs in the regulation of energy metabolism. Animal models have provided solid evidence that genetically induced obesity leads to long-lasting overstimulation of endocannabinoid system synthesis resulting in permanent overactivation of CB1, which may then contribute to the maintenance of this disease. Importantly, at peripheral level, CB1 activation has been shown to stimulate lipogenesis in adipocytes. CB1 blockers increase adiponectin production in adipocytes, which leads to increased fatty acid oxidation and free fatty acid clearance. Moreover, CB1 has been shown to be up-regulated in adipocytes derived from obese rodents. These results support the role of endocannabinoids in the development and maintenance of obesity, paving the way for the development of a new class of drugs such as the CB1 blockers as a therapy for tackling obesity and the associated major cardiovascular risk factors.
A field-evolved differential filtration method for recovery of schistosome cercariae (1984)

Modifications to Theron 's (1979) differential filtration technique are described which improve both sensitivity and reliability. Following pre-filtration to remove larger debris and some plankton, the sample is formalized; constant stirring prevents losses due to the cercarial stickiness normally caused by the fixation process. Once fixed, Schistosoma mansoni cercariae are reliably retained and well displayed on nylon monofilament cloth of 50 micrometers pore size. Such a coarse recovery filter permits very large samples to be processed and results in filters which are easy to read. Field comparison showed the method improved sensitivity by a factor of more than 20 times and laboratory evaluation indicated a recovery rate of over 80%.
Aminoferrocene-Based Prodrugs Activated by Reactive Oxygen Species (2011)

Cancer cells generally generate higher amounts of reactive oxygen species than normal cells. On the basis of this difference, prodrugs have been developed (e.g., hydroxyferrocifen), which remain inactive in normal cells, but become activated in cancer cells. In this work we describe novel aminoferrocene-based prodrugs, which, in contrast to hydroxyferrocifen, after activation form not only quinone methides (QMs), but also catalysts (iron or ferrocenium ions). The released products act in a concerted fashion. In particular, QMs alkylate glutathione, thereby inhibiting the antioxidative system of the cell, whereas the iron species induce catalytic generation of hydroxyl radicals. Since the catalysts are formed as products of the activation reaction, it proceeds autocatalytically. The most potent prodrug described here is toxic toward cancer cells (human promyelocytic leukemia (HL-60), IC(50) = 9 μM, and human glioblastoma-astrocytoma (U373), IC(50) = 25 μM), but not toxic (up to 100 μM) toward representative nonmalignant cells (fibroblasts).
Tetrandrine Inhibits Proinflammatory Cytokines, iNOS and COX-2 Expression in Human Monocytic Cells (2007)

Tetrandrine (TET), a bis-benzylisoquinoline alkaloid isolated from the dried root of hang-fang-chi (Stephania tetrandra S. Moore), is traditionally used in China for treating inflammation, hypertension and silicosis. In this study, our aim was to examine the anti-inflammatory mechanism of TET through measuring the inducible nitric oxide synthase (iNOS), cyclooxygenase-1, and -2 (COX-1 and COX-2) expression, cytokines (TNF-alpha, IL-4 and IL-8) formation, nitric oxide (NO) release and prostaglandin E2 (PGE2) generation in lipopolysaccharide (LPS)-induced human monocytic (THP-1) cells. Results showed that TET remarkably suppressed the LPS (1 microg/ml) induction of NO release and PGE2 generation. It also significantly attenuated the LPS-induced transcription of proinflammatory cytokines (TNF-alpha, IL-4 and IL-8) in a dose-dependent manner. Furthermore, TET at 100 microM significantly blocked the LPS induction of iNOS and COX-2 expression, but not the COX-1. Taken together, these results suggest that TET exerts anti-inflammatory effects probably through the suppression of COX-2 and iNOS expression.
Rhodium-Catalyzed Formation of Phosphorus-Boron Bonds: Synthesis of the First High Molecular Weight Poly(phosphinoborane) (1999)

An inorganic analogue of polystyrene, poly(phenylphosphinoborane) represents the first high molecular weight, well-characterized polymer with a backbone of alternating phosphorus and boron atoms. It is accessible by metal-catalyzed "dehydrocoupling" of a primary phosphane-borane adduct (see scheme).
Development and Performance Analysis of a Temporal Persistent Object Store POST/C++. (1996)

ODBMSs are used in advanced database applications to manage complex objects and objects that have associated inherent procedures. Some of the applications also require temporal and historical information management in the context of such object management. In this paper, we first discuss a temporal persistent object model that treats past states of persistent objects as objects. This model supports uniform manipulation of current and past states of objects. Then, we describe design and implementation of a temporal persistent object management system, named POST/C++. POST/C++ persistently stores C++-based objects and manages their histories of updates by user transactions based on the temporal persistent object model. Implementation of the first version of POST/C++ has been completed on Sun OS 4.1.2. Finally, we show performance analysis of POST/C++ using the extended OO1 benchmark, and discuss basic performance issues on our design and implementation. Keywords Temporal Database, Tempo...
Single Dose of Protein Vaccine with Peptide Nanofibers As Adjuvants Elicits Long-Lasting Antibody Titer (2017)

Self-assembling materials based on peptides have shown great potential as vaccine adjuvants. In our previous work, we have demonstrated that nanofibers based on D-peptide Nap-G<sup>D</sup>F<sup>D</sup>F<sup>D</sup>Y are good candidates for vaccine adjuvants. Here we further found that supramolecular hydrogels based on positively charged D-peptide Nap-G<sup>D</sup>F<sup>D</sup>F<sup>D</sup>Y<sup>D</sup>K as vaccine adjuvants could induce stronger immune response. We designed and synthesized two D-peptide derivatives, one with a positive charge (Nap-G<sup>D</sup>F<sup>D</sup>F<sup>D</sup>Y<sup>D</sup>K) and the other with a negative charge (Nap-G<sup>D</sup>F<sup>D</sup>F<sup>D</sup>Y<sup>D</sup>E). Both of them could form the hydrogels constructed by nanofibers. The nanofibers formed by Nap-G<sup>D</sup>F<sup>D</sup>F<sup>D</sup>Y<sup>D</sup>K promoted the more powerful immune response in mice against the antigen chicken egg albumin (OVA) than peptides Nap-G<sup>D</sup>F<sup>D</sup>F<sup>D</sup>Y and Nap-G<sup>D</sup>F<sup>D</sup>F<sup>D</sup>Y<sup>D</sup>E. Through cell experiments, we demonstrated that the main reason was that nanofibers formed by Nap-G<sup>D</sup>F<sup>D</sup>F<sup>D</sup>Y<sup>D</sup>K could enhance the uptake of OVA by primary antigen presenting cells. Most importantly, it was intriguing that the nanofibers based on Nap-G<sup>D</sup>F<sup>D</sup>F<sup>D</sup>Y<sup>D</sup>K could evoke long-lasting antibody titers for 28 weeks at a single dose of protein vaccine. Our study demonstrated that supramolecular hydrogels based on positively charged D-peptide were promising vaccine adjuvants and might be very useful for antibody production and vaccine development.
Pneumocephalus caused by Compressed Air Injury without Fracture (2017)

A 64-year-old man was admitted with swelling in the right periorbital area and right face and conjunctival hemorrhage with blurred vision in the right eye (Fig.
Variable Speed Limit Strategies to Reduce the Impacts of Traffic Flow Breakdown at Recurrent Freeway Bottlenecks (2014)

Variable Speed Limit (VSL) strategies identify and disseminate dynamic speed limits that are determined to be appropriate based on prevailing traffic conditions, road surface conditions, and weather conditions. This dissertation develops and evaluates a shockwave-based VSL system that uses a heuristic switching logic-based controller with specified thresholds of prevailing traffic flow conditions. The system aims to improve operations and mobility at critical bottlenecks. Before traffic breakdown occurrence, the proposed VSL’s goal is to prevent or postpone breakdown by decreasing the inflow and achieving uniform distribution in speed and flow. After breakdown occurrence, the VSL system aims to dampen traffic congestion by reducing the inflow traffic to the congested area and increasing the bottleneck capacity by deactivating the VSL at the head of the congested area. The shockwave-based VSL system pushes the VSL location upstream as the congested area propagates upstream. In addition to testing the system using infrastructure detector-based data, this dissertation investigates the use of Connected Vehicle trajectory data as input to the shockwave-based VSL system performance. Since the field Connected Vehicle data are not available, as part of this research, Vehicle-to-Infrastructure communication is modeled in the microscopic simulation to obtain individual vehicle trajectories. In this system, wavelet transform is used to analyze aggregated individual vehicles’ speed data to determine the locations of congestion. The currently recommended calibration procedures of simulation models are generally based on the capacity, volume and system-performance values and do not specifically examine traffic breakdown characteristics. However, since the proposed VSL strategies are countermeasures to the impacts of breakdown conditions, considering breakdown characteristics in the calibration procedure is important to have a reliable assessment. Several enhancements were proposed in this study to account for the breakdown characteristics at bottleneck locations in the calibration process. In this dissertation, performance of shockwave-based VSL is compared to VSL systems with different fixed VSL message sign locations utilizing the calibrated microscopic model. The results show that shockwave-based VSL outperforms fixed-location VSL systems, and it can considerably decrease the maximum back of queue and duration of breakdown while increasing the average speed during breakdown.
Circular dichroism and fluorescence studies on a cation channel forming plasma membrane proteolipid (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCircular dichroism and fluorescence studies on a cation channel forming plasma membrane proteolipidVictor S. Sapirstein and Thomas C. RoundsCite this: Biochemistry 1983, 22, 14, 3330–3335Publication Date (Print):July 5, 1983Publication History Published online1 May 2002Published inissue 5 July 1983https://pubs.acs.org/doi/10.1021/bi00283a005https://doi.org/10.1021/bi00283a005research-articleACS PublicationsRequest reuse permissionsArticle Views61Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Telecommunications and IT in Pacific Islands development (1994)

This article examines the impact and implications of telecommunications and information technologies against the backdrop of development aspirations in three ‘representative’ Pacific Island nations—the Cook Islands, Republic of Fiji, and Papua New Guinea. These three countries represent a wide range of development potential—from the relatively mature, export economy of Fiji; to the resource‐rich Papua New Guinea; and tourism‐dependent Cook Islands—as well as provide a sampling of the divergent approaches to development and the perceived role that technology is expected to play. This article specifically focuses on the broad social, economic, and political impact of recent telecommunications developments. Such developments are considered in the light of each country's individual development programmes and their common desire to increase their respective participation in the global economy. It is argued that if development aspirations are to be realized, respective national telecommunication policies must attempt to achieve multiple objectives: some economic, and some social. Finally, placing such an examination in a regional context, the country case studies are used as background to generate three alternative scenarios from which policy considerations are examined and possible recommendations discussed.
Product yield and hydrogen consumption selectivity tests for coal liquefaction catalyst development (1981)

A method for analyzing the experimental results of coal liquefaction reactions which is applicable to a number of aspects of coal liquefaction research and process control, including rapid selectivity and performance screening for catalysts; correlation of laboratory results with process parameters; and optimization of product yield with plant process conditions is described here. Ternary diagrams of product/by-product distributions for the coal liquefaction using Co/Mo catalysts combined with a hyperbolic relationship for the conversion of various hydrocarbon fractions can be used for catalyst screening. A hydrogen consumption diagram used to provide a more significant selectivity test than the hyperbolic correlation is also included. (BLM)
The Natriuretic Peptides and Fat Metabolism (2012)

A recent study adds to growing evidence that natriuretic peptides, secreted by the heart, influence fat metabolism. Mice with impaired clearance of these peptides had reduced fat mass and a metabolism shifted toward the consumption of excess calories.
Simplified differential phase optical microscope (1986)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Haeyang Chung, L. M. Walpita, and William S. C. Chang, "Simplified differential phase optical microscope," Appl. Opt. 25, 3014-3017 (1986) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
A Placebo-Controlled Trial of Oral Cladribine for Relapsing Multiple Sclerosis (2010)

Treatment with cladribine tablets significantly reduced relapse rates, the risk of disability progression, and MRI measures of disease activity at 96 weeks. The benefits need to be weighed against the risks. (ClinicalTrials.gov number, NCT00213135.)