gebhart/patrepeval huggingface dataset:
Hematogenous Micrometastases in Osteosarcoma Patients (2005)

Bone marrow and peripheral blood samples from 60 patients with suspected bone sarcoma were examined for the presence and number of micrometastatic osteosarcoma cells by a sensitive immunomagnetic detection assay, using in parallel two osteosarcoma-associated antibodies. Forty-nine of the patients had osteosarcoma, and of these, as many as 31 (63%) had tumor cells in bone marrow, in many cases with a high number of cells. Only four (8%) were positive also in blood. None of 38 control bone marrow samples were positive, including 11 from patients with suspected bone sarcoma at time of sampling who later were found not to have osteosarcoma. Fifteen of 28 patients without overt metastases at primary diagnosis (54%) were positive, 12 of whom had localized high-grade primary tumors in the extremity. Four of these have relapsed compared with none of 10 negative patients. In the group of 22 patients with extremity localized nonmetastatic osteosarcoma, information was available on the histologic response to preoperative chemotherapy in 15 patients. None of the three patients in the bone marrow-negative group who had a poor response to chemotherapy have relapsed, whereas two of the four poor responders in the bone marrow-positive cohort are dead of disease. Among 12 patients with overt metastasis at primary diagnosis, 11 (92%) were positive in bone marrow with a very high number of osteosarcoma cells. The immunomagnetically isolated cells were further characterized by the use of fluorescent latex microparticles with surface-bound antibodies targeting different membrane markers. Moreover, in cases with numerous osteosarcoma cells in bone marrow attempts to grow the selected cells in vitro were successful in two of eight attempts, and in two of five cases, isolated cells produced tumors with osteosarcoma characteristics in nude mice. In conclusion, already at primary diagnosis, a very high fraction of osteosarcoma patients had malignant cells in bone marrow, and a correlation between the presence of tumor cells, clinical stage, and disease progression was found. The data show the clinical potential of this immunomagnetic method. Attempts to subgroup osteosarcoma patients for more individualized treatment based on the presence of micrometastatic cells should be studied in a larger cohort of patients.
Estimation of errors in the integration of GPS and INS (2005)

Estimation of errors in the integrated navigation system that consists of a very low-grade inertial measurement unit (IMU) and a single antenna GPS measurement system is studied in this paper. Observability properties of the errors are investigated with a control-theoretic approach. The uncertainties in attitude, gyro bias, and GPS antenna lever arm are shown to cause errors in the estimates of position, velocity, and accelerometer bias. Changes in the acceleration of vehicles improve the estimates of attitude and gyro bias. Changes in the angular velocity enhance the lever arm estimate. Both the motions of translation and constant angular velocity have no influence on the estimation of the lever arm. A car test was performed to confirm the observability analysis.
CD4+CD25+ Regulatory T Cells Can Mediate Suppressor Function in the Absence of Transforming Growth Factor β1 Production and Responsiveness (2002)

CD4(+)CD25(+) regulatory T cells inhibit organ-specific autoimmune diseases induced by CD4(+)CD25(-) T cells and are potent suppressors of T cell activation in vitro. Their mechanism of suppression remains unknown, but most in vitro studies suggest that it is cell contact-dependent and cytokine independent. The role of TGF-beta1 in CD4(+)CD25(+) suppressor function remains unclear. While most studies have failed to reverse suppression with anti-transforming growth factor (TGF)-beta1 in vitro, one recent study has reported that CD4(+)CD25(+) T cells express cell surface TGF-beta1 and that suppression can be completely abrogated by high concentrations of anti-TGF-beta suggesting that cell-associated TGF-beta1 was the primary effector of CD4(+)CD25(+)-mediated suppression. Here, we have reevaluated the role of TGF-beta1 in CD4(+)CD25(+)-mediated suppression. Neutralization of TGF-beta1 with either monoclonal antibody (mAb) or soluble TGF-betaRII-Fc did not reverse in vitro suppression mediated by resting or activated CD4(+)CD25(+) T cells. Responder T cells from Smad3(-/-) or dominant-negative TGF-beta type RII transgenic (DNRIITg) mice, that are both unresponsive to TGF-beta1-induced growth arrest, were as susceptible to CD4(+)CD25(+)-mediated suppression as T cells from wild-type mice. Furthermore, CD4(+)CD25(+) T cells from neonatal TGF-beta1(-/-) mice were as suppressive as CD4(+)CD25(+) from TGF-beta1(+/+) mice. Collectively, these results demonstrate that CD4(+)CD25(+) suppressor function can occur independently of TGF-beta1.
Computer-assisted Continuous Infusions of Fentanyl during Cardiac Anesthesia (1985)

The design and implementation of a computer-assisted continuous infusion (CACI) system to rapidly attain and maintain a constant plasma fentanyl concentration (PFC), as well as a CACI system that allowed the anesthesiologist to change the plasma level of fentanyl during cardiac anesthesia, were developed. In 30 patients (three groups of 10 patients each) these two automated methods of fentanyl infusion were compared with a manual fentanyl administration method. There was excellent agreement in the measured/predicted PFC ratios with the CACI stable fentanyl level system (ratio = 0.99, n = 91) and in the CACI variable fentanyl level system (ratio = 1.08, n = 79). The stable fentanyl level group of patients received significantly more (P less than 0.05) fentanyl than did the other groups. The CACI variable fentanyl level group of patients had greater hemodynamic stability, required significantly (P less than 0.05) fewer adjuvant drug interventions and experienced significantly (P less than 0.05) fewer hypotensive and hypertensive episodes than the manual, bolus fentanyl (control) group. These data show that a computer-assisted automated infusion of fentanyl is safe and as good as manual methods. CACI has greater potential as a new method of intravenous anesthesia administration.
Hardware software codesign of a safety-critical embedded computer system for an automatic endoscope (2003)

Hardware-software codesign is presented for a safety-critical embedded computer system. The system is applied for endoscope control and navigation. The embedded system architecture provides high performance computing for real-time implementation of machine vision algorithms and fault-tolerance for patient safety. It consists of five processor cores, local memory, I/O interface and multi-port shared memory. The hardware and software system architectures are co-designed. A virtual hardware is developed to execute the application and system software tasks. The system is designed and modeled using VHDL and Eaglei toolset. We have limited system verification to co-verification of system hardware architecture and fault-tolerance strategies. Co-verification results indicate that the system performance degrades gracefully under various fault scenarios.
A New Resistance Gene, <i>linB</i> , Conferring Resistance to Lincosamides by Nucleotidylation in <i>Enterococcus faecium</i> HM1025 (1999)

Resistance to lincomycin and clindamycin in the clinical isolate Enterococcus faecium HM1025 is due to a ribosomal methylase encoded by an ermAM-like gene and the plasmid-mediated inactivation of these antibiotics. We have cloned and determined the nucleotide sequence of the gene responsible for the inactivation of lincosamides, linB. This gene encodes a 267-amino-acid lincosamide nucleotidyltransferase. The enzyme catalyzes 3(5'-adenylation) (the adenylation of the hydroxyl group in position 3 of the molecules) of lincomycin and clindamycin. Expression of linB was observed in both Escherichia coli and Staphylococcus aureus. The deduced amino acid sequence of the enzyme did not display any significant homology with staphylococcal nucleotidyltransferases encoded by linA and linA' genes. Sequences homologous to linB were found in 14 other clinical isolates of E. faecium, indicating the spread of the resistance trait in this species.
Morbidity and Mortality Among Low Birth Weight Infants Exposed to an Intravenous Vitamin E Product, E-Ferol (1989)

In April 1984, the US FDA was notified of an unusual clinical syndrome consisting of ascites, liver and renal failure, thrombocytopenia, and death among low birth weight infants exposed to an intravenous vitamin E preparation, E-Ferol. The product, which had not been tested for safety prior to marketing, was voluntarily withdrawn from the market in early April. To further investigate the reported associations, the FDA conducted a retrospective cohort study among seven neonatal intensive care units where the product had been used. Standardized abstraction forms were completed for infants admitted to a unit between Nov 1, 1983, and April 30, 1984. Included in the study were 379 infants weighing 2,000 g or less and surviving at least two days; 148 (39%) had been exposed to E-Ferol. Compared with the unexposed infants, the exposed infants were more likely to die and to have ascites, hepatomegaly, thrombocytopenia, and a combination of clinical events similar to the syndrome initially reported. We conclude that the use of E-Ferol in these neonatal intensive care units was associated with increased morbidity and mortality among exposed infants.
Light Regulation of Leaf Mitochondrial Pyruvate Dehydrogenase Complex (1992)

Light-dependent inactivation of mitochondrial pyruvate dehydrogenase complex (mtPDC) in pea (Pisum sativum L.) leaves was further characterized, and this phenomenon was extended to several monocot and dicot species. The light-dependent inactivation of mtPDC in vivo was rapidly reversed in the dark, even after prolonged illumination. The mtPDC can be efficiently cycled through the inactivated-reactivated status by rapid light-dark cycling. Light-dependent inactivation of mtPDC was shown to be suppressed by inhibitors of photorespiratory carbon metabolism, including 2-pyridylhydroxymethane sulfonate, isonicotinic acid hydrazide, and aminoacetonitrile, and by an inhibitor of photosynthesis, 3-(3,4-dichlorophenyl)-1,1-dimethylurea. Glycine fed to pea leaf strips in the dark yielded partially inactivated leaf mtPDC, and this inactivation was blocked by inhibitors of glycine oxidation. It is concluded that the photorespiratory glycine to serine conversion that occurs in C(3) leaf mitochondria can provide the NADH to drive oxidative phosphorylation and subsequent inactivation of mtPDC. Glycine oxidation also produces ammonium ion, which has been shown to enhance the inactivation of mtPDC in vitro by stimulating the pyruvate dehydrogenase kinase that catalyzes the phosphorylation (inactivation) of the mtPDC. Thus, light-dependent, photorespiration-stimulated inactivation of the mtPDC can regulate carbon entry into the Krebs cycle during C(3) photosynthesis.
Bridgehead nitrogen heterocycles. I. 2H(and 4H)-Pyrimido[1,2-b]pyridazin-2(and 4)-one. 3H-Imidazo[1,2-b]pyridazin-2-one, and 7H-(1,3,4-)thiadiazolo[3,2-a]pyrimidin-7-one systems (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBridgehead nitrogen heterocycles. I. 2H(and 4H)-Pyrimido[1,2-b]pyridazin-2(and 4)-one. 3H-Imidazo[1,2-b]pyridazin-2-one, and 7H-(1,3,4-)thiadiazolo[3,2-a]pyrimidin-7-one systemsKurt Pilgram, Jerome G. Kuderna, and Richard D. SkilesCite this: J. Org. Chem. 1971, 36, 23, 3506–3510Publication Date (Print):November 1, 1971Publication History Published online1 May 2002Published inissue 1 November 1971https://pubs.acs.org/doi/10.1021/jo00822a008https://doi.org/10.1021/jo00822a008research-articleACS PublicationsRequest reuse permissionsArticle Views167Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Practical leakage-resilient identity-based encryption from simple assumptions (2010)

We design the first Leakage-Resilient Identity-Based Encryption (LR-IBE) systems from static assumptions in the standard model. We derive these schemes by applying a hash proof technique from Alwen et.al. (Eurocrypt '10) to variants of the existing IBE schemes of Boneh-Boyen, Waters, and Lewko-Waters. As a result, we achieve leakage-resilience under the respective static assumptions of the original systems in the standard model, while also preserving the efficiency of the original schemes. Moreover, our results extend to the Bounded Retrieval Model (BRM), yielding the first regular and identity-based BRM encryption schemes from static assumptions in the standard model.
Anserini (2018)

This work tackles the perennial problem of reproducible baselines in information retrieval research, focusing on bag-of-words ranking models. Although academic information retrieval researchers have a long history of building and sharing systems, they are primarily designed to facilitate the publication of research papers. As such, these systems are often incomplete, inflexible, poorly documented, difficult to use, and slow, particularly in the context of modern web-scale collections. Furthermore, the growing complexity of modern software ecosystems and the resource constraints most academic research groups operate under make maintaining open-source systems a constant struggle. However, except for a small number of companies (mostly commercial web search engines) that deploy custom infrastructure, Lucene has become the de facto platform in industry for building search applications. Lucene has an active developer base, a large audience of users, and diverse capabilities to work with heterogeneous collections at scale. However, it lacks systematic support for ad hoc experimentation using standard test collections. We describe Anserini, an information retrieval toolkit built on Lucene that fills this gap. Our goal is to simplify ad hoc experimentation and allow researchers to easily reproduce results with modern bag-of-words ranking models on diverse test collections. With Anserini, we demonstrate that Lucene provides a suitable framework for supporting information retrieval research. Experiments show that our system efficiently indexes large web collections, provides modern ranking models that are on par with research implementations in terms of effectiveness, and supports low-latency query evaluation to facilitate rapid experimentation
Mineralocorticoid Receptor Function in Major Depression (2003)

Despite high baseline cortisol levels, patients with major depression show high functional activity of the MR system. Paired with the body of evidence regarding decreased sensitivity to GR agonists, these data suggest an imbalance in the MR/GR ratio. The balance of MR and GR is known to affect brain serotonin systems and may play an etiologic role in serotonin receptor changes observed in patients with major depression.
Chip-Integrated Geometric Metasurface As a Novel Platform for Directional Coupling and Polarization Sorting by Spin–Orbit Interaction (2018)

The focus of the research in metasurfaces has mainly been on the manipulation of the electromagnetic waves in free space during the past few years, which generally require thousands of subwavelength meta-atoms or even more. In this paper, we propose a conceptually new approach that chip-integrated metasurface can behave as a promising compact platform to control the propagation of guided waves when it is integrated with optical waveguide. As a proof of the concept, geometric metasurfaces consisting of only seven rotating anisotropic antennas, both metallic and dielectric, are integrated with silicon-on-insulator waveguide. Benefiting from the geometric phase shift stemming from spin-orbit interaction in metasurfaces, linearly gradient wavefront is generated along the waveguide, which is equivalent to introduce a unidirectional effective wavevector and thus leads to directional coupling. Inspired by the spin dependent gradient wavefront, opposite light flow is excited in the integrated waveguide by switching the handedness of incidence, which may provide a potential pathway to integrated polarization sorters and switchers.
Accelerated Differentiation in Response to Retinoic Acid After Retrovirally Mediated Gene Transfer of GAP‐43 into Mouse Neuroblastoma Cells (1992)

Although substantial evidence exists for the involvement of growth-associated protein-43 (GAP-43) in neuronal development and regeneration, the precise role of this protein in neurite outgrowth is currently debated. To investigate the role of GAP-43 in the initiation of neurite outgrowth, we transfected a full-length cDNA coding for GAP-43 into a mouse neuroblastoma cell line (Neuro-2a) which can be differentiated to a neuronal phenotype using retinoic acid (RA). We show that the consequent overexpression of GAP-43 results in a change in the basic morphology of these cells, but is not in itself sufficient to induce the extension of neurites. However, overexpression of GAP-43 results in a marked acceleration of neurite formation in response to RA. We propose that while GAP-43 does not trigger the initiation of neurite extension, its expression is rate-limiting for neurite outgrowth in response to differentiation agents such as RA.
A novel phosphatase upregulated in<i>Akp3</i>knockout mice (2007)

Reexamination of the Akp3(-/-) mouse intestine showed that, despite the lack of intestinal alkaline phosphatase (IAP), the Akp3(-/-) gut still had considerable alkaline phosphatase (AP) activity in the duodenum and ileum. This activity is due to the expression of a novel murine Akp6 gene that encodes an IAP isozyme expressed in the gut in a global manner (gIAP) as opposed to duodenum-specific IAP (dIAP) isozyme encoded by the Akp3 gene. Phylogenetically, gIAP is similar to the rat IAP I isozyme. Kinetically, gIAP displays a 5.7-fold reduction in catalytic rate constant (k(cat)) and a 30% drop in K(m), leading to a 4-fold reduction k(cat)/K(m) compared with dIAP, and these changes in enzymatic properties can all be attributed to a crucial R317Q substitution. Western and Northern blot analyses document the expression of Akp6 in the gut, from the duodenum to the ileum, and it is upregulated in the jejunum and ileum of Akp3(-/-) mice. Developmentally, Akp3 expression is turned on during postnatal days 13-15 and exclusively in the duodenum, whereas Akp6 and Akp5 are expressed from birth throughout the gut with enhanced expression at weaning. Posttranslational modifications of gIAP have a pronounced effect on its catalytic properties. Given the low catalytic efficiency of gIAP, its upregulation during fat feeding, its sequence similarity with rat IAP I, and the fact that rat IAP I has been implicated in the upregulation of surfactant-like particles during fat intake, it appears likely that gIAP may have a role in mediating the accelerated fatty acid intake observed in Akp3(-/-) mice fed a high-fat diet.
Treatment with Piperacillin‐Tazobactam and False‐Positive<i>Aspergillus</i>Galactomannan Antigen Test Results for Patients with Hematological Malignancies (2004)

We report the occurrence of a high rate of false-positive test results during the surveillance of hematology patients for galactomannan (GM) antigenemia. Among 218 patients surveyed from June 2002 through June 2003, 42 (19.3%) had > or =1 serum sample positive for GM (optical density index, >1.5). Of these patients, 38 had no additional evidence of invasive aspergillosis, and, therefore, their test results were considered to be false-positives. Case-control analysis showed that treatment with piperacillin-tazobactam was the only risk factor significantly associated with receiving false-positive test results. When tested for GM antigen, 3 of 4 piperacillin-tazobactam batches had positive results. Physicians should be aware of the possible interference of treatment with piperacillin-tazobactam when interpreting the results of the GM assay.
Genome-wide methylation analysis identifies a core set of hypermethylated genes in CIMP-H colorectal cancer (2017)

Our genome-wide characterization of DNA methylation in colorectal cancer has identified 132 genes hypermethylated in 100% of CIMP-H samples. Three genes, EYA4, TLX1 and TFPI2 are hypermethylated in >90% of all tumour samples, regardless of CIMP subtype.
A fuzzy block replacement algorithm for disk caches (2002)

In this paper, we present a new block replacement algorithm for disk caches. Our Fuzzy Block Replacement Algorithm (fuzzy block-RA) utilizes nine fuzzy rules to pick out the block to be evicted when an I/O reference causes a miss on a filled up disk cache. The decision making process is based on the age of a block and the frequency at which references are made to it. Optimization of the knowledge base to specific applications is easily possible by modifying the inference rules or tuning of the membership functions. The simulations performed using our algorithm shows that the miss rate improves with a fuzzy block-RA when compared with standard algorithms. The use of disk traces gathered from a commercial disk subsystem in the simulation ensures the practical validity of the results.
Consequences of Diabetes (2004)

This is the third of three articles dealing with the International Diabetes Federation meeting, which was held in Paris, 24–29 August 2003.

Paul Valensi (Bobigny, France) discussed approaches to silent myocardial ischemia in persons with diabetes. Addressing the question of whether it is in fact advisable to detect cardiovascular disease (CVD) in persons without history of myocardial infarction or angina, he noted the poor prognosis of persons with diabetes, whose risk of myocardial infarction in the absence of CVD is similar to that of persons without diabetes and with a prior myocardial infarction. Those having evidence of CVD are at particularly increased risk, with half dying within 8 years (1). One-year mortality after thrombolysis is increased by half in persons with diabetes, and survival of persons without diabetes who have had a second myocardial infarction is similar to that of those with diabetes after an initial event (2). The prevalence at autopsy of high grade and multilevel coronary atherosclerosis in diabetic individuals without clinical coronary artery disease (CAD) is similar to that of persons without diabetes with clinical CAD, both for males and for females (3). In a French multicenter study of 417 asymptomatic diabetic persons with at least two additional risk factors undergoing thallium scintigraphy with exercise or dipyridamole, 162 had positive nuclear study, and of 70 having angiography, 39 were found to have evidence of CAD, a positive predictive value of only 56%. Other studies suggest that approximately one-third of asymptomatic persons with diabetes have a positive screening test, but that only approximately one-third of these have positive results on angiography, suggesting poor correlation between functional and morphological abnormality. Alternatively, Valensi suggested, scintigraphy may actually be more sensitive than angiography to the presence of CAD, noting that there certainly is evidence that an abnormal study is associated with …