gebhart/patrepeval huggingface dataset:
Actin polymerization. The effect of brevin on filament size and rate of polymerization. (1984)

Fluorescent probes covalently bound to actin or to the actin binding protein, brevin, have been utilized to provide information about actin filaments formed in the presence of brevin as well as about the effect of brevin on the rate of polymerization. At actin to brevin ratios of 10:1 to 100:1, the observed diffusion coefficients of filaments, as measured by fluorescence photobleaching recovery using rhodamine-labeled actin or fluorescein-labeled brevin, are similar to those calculated from theoretical considerations for rigid rods. At lower brevin concentrations, the observed diffusion coefficients for actin filaments are lower than predicted, indicating that the filament structure is closer to that observed in the absence of brevin where filaments are immobilized due to interactions between them. The fluorescein-labeled brevin was found to be about as effective in influencing actin polymerization as unlabeled brevin. Using pyrene-labeled actin, we show that brevin binds 2 mol of monomeric actin. We conclude that at sufficiently high brevin concentration there is one brevin molecule per actin filament. From measurements of the initial rate of polymerization at 5.9 microM actin in the presence of brevin, we calculate both the apparent elongation rate constant and dissociation rate constant from one end (presumably the slow-growing end) of the actin filament. The former is highly dependent on Mg2+ concentration while the latter is not.
A Calcium-Nickel Phosphate Dehydrogenation Catalyst (1951)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Calcium-Nickel Phosphate Dehydrogenation CatalystE. C. Britton, A. J. Dietzler, and C. R. NoddingsCite this: Ind. Eng. Chem. 1951, 43, 12, 2871–2874Publication Date (Print):December 1, 1951Publication History Published online1 May 2002Published inissue 1 December 1951https://pubs.acs.org/doi/10.1021/ie50504a059https://doi.org/10.1021/ie50504a059research-articleACS PublicationsRequest reuse permissionsArticle Views197Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Portable performance on heterogeneous architectures (2013)

Trends in both consumer and high performance computing are bringing not only more cores, but also increased heterogeneity among the computational resources within a single machine. In many machines, one of the greatest computational resources is now their graphics coprocessors (GPUs), not just their primary CPUs. But GPU programming and memory models differ dramatically from conventional CPUs, and the relative performance characteristics of the different processors vary widely between machines. Different processors within a system often perform best with different algorithms and memory usage patterns, and achieving the best overall performance may require mapping portions of programs across all types of resources in the machine. To address the problem of efficiently programming machines with increasingly heterogeneous computational resources, we propose a programming model in which the best mapping of programs to processors and memories is determined empirically. Programs define choices in how their individual algorithms may work, and the compiler generates further choices in how they can map to CPU and GPU processors and memory systems. These choices are given to an empirical autotuning framework that allows the space of possible implementations to be searched at installation time. The rich choice space allows the autotuner to construct poly-algorithms that combine many different algorithmic techniques, using both the CPU and the GPU, to obtain better performance than any one technique alone. Experimental results show that algorithmic changes, and the varied use of both CPUs and GPUs, are necessary to obtain up to a 16.5x speedup over using a single program configuration for all architectures.
Investigating keyframe selection methods in the novel domain of passively captured visual lifelogs (2008)

The SenseCam is a passive capture wearable camera, worn around the neck, and when worn continuously it takes an average of 1,900 images per day.It can be used to create a personal lifelog or visual recording of the wearer's life which can be helpful as an aid to human memory.For such a large amount of visual information to be useful, it needs to be structured into "events", which can be achieved through automatic segmentation.An important component of this structuring process is the selection of keyframes to represent individual events.This work investigates a variety of techniques for the selection of a single representative keyframe image from each event, in order to provide the user with an instant visual summary of that event.In our experiments we use a large test set of 2,232 lifelog events collected by 5 users over a time period of one month each.We propose a novel keyframe selection technique which seeks to select the image with the highest "quality" as the keyframe.The inclusion of "quality" approaches in keyframe selection is demonstrated to be useful owing to the high variability in image visual quality within passively captured image collections.
Evaluation of the safety of long-term, daily oral administration of grapiprant, a novel drug for treatment of osteoarthritic pain and inflammation, in healthy dogs (2015)

Results suggested the safety of long-term oral administration of grapiprant to dogs. Efficacy of grapiprant in the treatment of dogs with osteoarthritis needs to be evaluated in other studies.
A high sensitivity vector accelerometer based on tri-axial fiber Bragg grating (2012)

Firstly, a single-axis FBG accelerometer with intensity modulation-direct detection interrogation system was put forward and designed in the paper. Experiments with different excitation frequencies were implemented, which demonstrate its good mechanical structure and fabrication technology. Accordingly, a novel tri-axis FBG accelerometer based on the single-axis FBG accelerometer was proposed and a series of periodic vibration tests were finished to prove its performance at different excitation frequencies. The response of the tri-axis vector FBG accelerometer can keep up with the increasing excitation frequency with good signal-to-noise ratio (SNR) within 160 Hz. The suitable measurement frequency range of the accelerator is between 0 and 500 Hz. The cross-axis response among three axes is analyzed. These experiments indicate that horizontal axes have less influence on the vertical axis vibration of FBG.
Advances in Giant Magnetoresistance Biosensors With Magnetic Nanoparticle Tags: Review and Outlook (2008)

We present a review of giant magnetoresistance (GMR) spin valve sensors designed for detection of magnetic nanoparticles as biomolecular labels (nanotags) in magneto-nano biodetection technology. We discuss the intricacy of magneto-nano biosensor design and show that as few as approximately 14 monodisperse 16-nm superparamagnetic nanoparticles can be detected by submicron spin valve sensors at room temperature without resorting to lock-in (narrow band) detection. GMR biosensors and biochips have been successfully applied to the detection of biological events in the form of both protein and DNA assays with great speed, sensitivity, selectivity, and economy. The limit of molecular detection is well below 10 pM in concentration, and the protein or DNA assay time can be under two hours. The technology is highly scalable to deep multiplex detection of biomarkers in a complex disease, and amenable to integration of microfluidics and CMOS electronics for portable applications. On-chip CMOS circuitry makes a sensor density of 0.1-1 million sensors per square centimeter feasible and affordable. The theoretical and experimental results thus far suggest that magneto-nano biochip-based GMR sensor arrays and nanotags hold great promise in biomedicine, particularly for point-of-care molecular diagnostics of cancer, infectious diseases, radiation injury, cardiac diseases, and other diseases.
The Role of Slow Changes in Catecholamine Receptor Function in The Action Of Antidepressant Drugs (1990)

This review addresses the functional significance of the effects of long term treatment with antidepressant drugs upon catecholaminergic receptors. Reduced function has been reported at beta-adrenergic, alpha2-adrenergic, dopamine (DA) autoreceptors and postsynaptic D1 DA receptors. Enhanced responsiveness at postsynaptic alpha1-adrenergic and D2 DA receptors has also been reported. It is argued that the ‘down regulation' of beta-adrenoceptors is unlikely to represent the mechanism of action of antidepressant drugs. The enhanced responsiveness of alpha1- and D2 receptors seems relevant to the action of antidepressant drugs in several animal models of depression. Similar changes should now be sought in people.
A caching policy for continuous media objects based on logical caches and object partitioning (2001)

In this paper, we propose a proxy server management scheme to service continuous media objects on the wide area networks. In the proposed proxy management policy, base on the tree-like proxy server configuration, two physical proxy servers work as one logical cache. Moreover, each object is partitioned into two parts: the front-end and rear-end partition in order to reduce cache space management overhead that the cache space allocation algorithm works in two phases. In the first phase caching, two partitions of the requested object is cached in its corresponding physical proxy server of the logical cache: the front-end partition is cached in the child proxy server while the rear-end one in the parent proxy server. In the second phase, the rear-end partition of the requested object, which has been already cached in the parent proxy server in its first phase caching, will be cached again in the child proxy server of the logical cache depending on their access frequencies.
Asymptotically perfect wideband focusing of multiring circular arrays (2005)

The concept of coherent focusing of sensor arrays, introduced by Wang and Kaveh, led to the development of high-performance and computationally efficient algorithms for wideband direction finding and beamforming. Nonetheless, the quality of focusing depends on the understanding and the proper exploitation of specific array manifold properties. Circular arrays exhibit uniform (isotropic) performance over the entire azimuthal range and allow the use of fast algorithms, originally developed for uniform linear arrays, by decomposing the manifold into circular harmonics. Coherent wideband focusing of circular arrays suffers from ambiguities, noise warping, and numerical ill conditioning. In this work, it is shown that a fast orthonormal beamspace transformation combining the responses of two concentric rings can perfectly focus wideband sources at all azimuth angles in the circular harmonic domain in the limit of infinite number of sensors. The information loss after focusing is minimized through an analytical approach. The proposed focusing scheme is computationally very efficient and can be directly extended to multiring circular arrays that are arranged into a set of nested two-ring subarrays to cover very large bandwidths.
Discoloration of Tetrabromophthalic Anhydride Polyseter Resins (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDiscoloration of Tetrabromophthalic Anhydride Polyseter ResinsSydney M. Spatz, Herman Stone, Marvin Koral, Russel I. Steiner, and Hervey W. Ackerman Jr.Cite this: Ind. Eng. Chem. Prod. Res. Dev. 1969, 8, 4, 391–396Publication Date (Print):December 1, 1969Publication History Published online1 May 2002Published inissue 1 December 1969https://pubs.acs.org/doi/10.1021/i360032a031https://doi.org/10.1021/i360032a031research-articleACS PublicationsRequest reuse permissionsArticle Views74Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
The synthesis of platelet-activating factor modulates chemotaxis of monocytes induced by HIV-1 Tat (1999)

HIV-1 Tat protein has been shown to induce chemotaxis and recruitment of monocytes. In the present study, we evaluated whether HIV-1 Tat protein was able to induce the synthesis of platelet-activating factor (PAF), which is a potent mediator of cell motility, and whether the synthesis of PAF was instrumental in triggering Tat-induced monocyte chemotaxis. The results obtained indicate that Tat, but not gp120 and gp41, induced a time-dependent synthesis of PAF from monocytes at concentration as low as 0.1 ng/ml. As inferred by the inhibitory effect of anti-Flt-1 antibody and by the desensitization of monocytes following preincubation with vascular endothelial growth factor, the synthesis of PAF by monocytes stimulated with Tat was induced by activation of vascular endothelial growth factor receptor 1. Moreover, the Tat-induced chemotaxis of monocytes was abrogated both by WEB 2170 and by CV 3988, two chemically unrelated PAF receptor antagonists, suggesting that the synthesized PAF modulates the chemotactic response of monocytes to Tat. In conclusion, the results of the present study indicate that Tat-induced PAF synthesis plays a critical role in triggering the events involved in the migratory response of monocytes.
Topological Map Extraction From Overhead Images (2019)

We propose a new approach, named PolyMapper, to circumvent the conventional pixel-wise segmentation of (aerial) images and predict objects in a vector representation directly. PolyMapper directly extracts the topological map of a city from overhead images as collections of building footprints and road networks. In order to unify the shape representation for different types of objects, we also propose a novel sequentialization method that reformulates a graph structure as closed polygons. Experiments are conducted on both existing and self-collected large-scale datasets of several cities. Our empirical results demonstrate that our end-to-end learnable model is capable of drawing polygons of building footprints and road networks that very closely approximate the structure of existing online map services, in a fully automated manner. Quantitative and qualitative comparison to the state-of-the-arts also show that our approach achieves good levels of performance. To the best of our knowledge, the automatic extraction of large-scale topological maps is a novel contribution in the remote sensing community that we believe will help develop models with more informed geometrical constraints.
Structural and optical properties of erbium-doped Ba0.7Sr0.3TiO3 thin films (2005)

Er-doped Ba0.7Sr0.3TiO3 (BST:Er) thin films prepared by the sol–gel technique have been investigated by means of x-ray diffraction (XRD), Raman, spectroscopic ellipsometry, Capacitance–voltage, and photoluminescence (PL) measurements. XRD results indicate that the film possess the highest degree of crystallinity at the annealing temperature of 700°C. The dependence of the refractive index on erbium concentration was also analyzed. In addition, the excitation-dependent PL studies indicate that the green emission peaks do not shift with the change in excitation power, while the integrated intensity increases monotonically with the increase in excitation power. The quenching mechanism of the green emission due to dopant concentrations and annealing temperatures was discussed in detail. All experimental results indicate that BST:Er thin films might be a potential candidate for optoelectronics devices.
An evolutionary approach to constructing effective software reuse repositories (1997)

Repositories for software reuse are faced with two interrelated problems: (1) acquiring the knowledge to initially construct the repository and (2) modifying the repository to meet the evolving and dynamic needs of software development organizations. Current software repository methods rely heavily on classification, which exacerbates acquistition and evolution problems by requiring costly classification and domain analysis efforts before a repository can be used effectively, This article outlines an approach that avoids these problems by choosing a retrieval method that utilizes minimal repository structure to effectively support the process of finding software conponents. The approach is demonstrated through a pair of proof-of-concept prototypes: PEEL, a tool to semiautomatically identify reusable components, and CodeFinder, a retrieval system that compensates for the lack of explicit knowledge structures through a spreading activation retrieval process. CodeFinder also allows component representations to be modified while users are searching for information. This mechanism adapts to the changing nature of the information in the repository and incrementally improves the repository while people use it. The combination of these techniques holds potential for designing software repositories that minimize up-front costs, effectively support the search process, and evolve with an organization's changing needs.
Genetic engineering of carbohydrate biosynthetic pathways in transgenic mice demonstrates cell cycle-associated regulation of glycoconjugate production in small intestinal epithelial cells. (1996)

Proliferation, migration-associated differentiation, and cell death occur continuously and in a spatially well-organized fashion along the crypt-villus axis of the mouse small intestine, making it an attractive system for studying how these processes are regulated and interrelated. A pathway for producing glycoconjugates was engineered in adult FVB/N transgenic mice by expressing a human alpha 1,3/4-fucosyltransferase (alpha 1,3/4-FT; EC 2.4.1.65) along the length of this crypt-villus axis. The alpha 1,3/4-FT can use lacto-N-tetraose or lacto-neo-N-tetraose core chains to generate Lewis (Le) blood group antigens Le(a) or Le(x), respectively, and H type 1 or H type 2 core chains to produce Leb and Le(y). Single- and multilabel immunohistochemical studies revealed that expression of the alpha 1,3/4-FT results in production of Le(a) and Leb antigens in both undifferentiated proliferated crypt cells and in differentiated postmitotic villus-associated epithelial cells. In contrast, Le(x) antigens were restricted to crypt cells. Villus enterocytes can be induced to reenter the cell cycle by expression of simian virus 40 tumor antigen under the control of a promoter that only functions in differentiated members of this lineage. Bitransgenic animals, generated from a cross of FVB/N alpha 1,3/4-FT with FVB/N simian virus 40 tumor antigen mice, expand the range of Le(x) expression to include villus-associated enterocytes that have reentered the cell cycle. Thus, the fucosylations unveil a proliferation-dependent switch in oligosaccharide production, as defined by a monoclonal antibody specific for the Le(x) epitope. These findings show that genetic engineering of oligosaccharide biosynthetic pathways can be used to define markers for entry into, or progression through, the cell cycle and to identify changes in endogenous carbohydrate metabolism that occur when proliferative status is altered in a manner that is not deleterious to the system under study.
Identification of Key Amino Acid Residues in a Thyrotropin Receptor Monoclonal Antibody Epitope Provides Insight into Its Inverse Agonist and Antagonist Properties (2008)

CS-17 is a murine monoclonal antibody to the human TSH receptor (TSHR) with both inverse agonist and antagonist properties. Thus, in the absence of ligand, CS-17 reduces constitutive TSHR cAMP generation and also competes for TSH binding to the receptor. The present data indicate that for both of these functions, the monovalent CS-17 Fab (50 kDa) behaves identically to the intact, divalent IgG molecule (150 kDa). The surprising observation that CS-17 competes for TSH binding to the human but not porcine TSHR enabled identification of a number of amino acids in its epitope. Replacement of only three human TSHR residues (Y195, Q235, and S243) with the homologous porcine TSHR residues totally abolishes CS-17 binding as detected by flow cytometry. TSH binding is unaffected. Of these residues, Y195 is most important, with Q235 and S243 contributing to CS-17 binding to a much lesser degree. The functional effects of CS-17 IgG and Fab on constitutive cAMP generation by porcinized human TSHR confirm the CS-17 binding data. The location of TSHR amino acid residues Y195, Q235, and S243 deduced from the crystal structure of the FSH receptor leucine-rich domain provides valuable insight into the CS-17 and TSH binding sites. Whereas hormone ligands bind primarily to the concave surface of the leucine-rich domains, a major portion of the CS-17 epitope lies on the opposite convex surface with a minor component in close proximity to known TSH binding residues.