gebhart/patrepeval huggingface dataset:
Regulation of thrombospondin-1 by natural and synthetic progestins in human breast cancer cells (2009)

Our recent studies show that progestins induce vascular endothelial growth factor (VEGF) in breast cancer cells that express mutant p53 protein. Here, we show that natural and synthetic progestins also induce thrombospondin-1 (TSP-1) mRNA and protein in T47-D and BT-474 breast cancer cells. Antiprogestin RU-486 inhibits the induction of VEGF and TSP-1 by progestins, suggesting that this effect of progestin is mediated by the progesterone receptor (PR). Actinomycin-D, but not puromycin, also blocks progestin-dependent induction of TSP-1. A putative progestin-response element was identified in the human TSP-1 promoter, which is consistent with the hypothesis that a progestin-PR complex might directly regulate transcription of the TSP-1 gene in human cells. Conditioned medium from progestin-treated breast cancer cells stimulates endothelial cell proliferation in the absence though not in the presence of antibody to TSP-1, indicating that TSP-1 secreted by breast cancer cells could be pro-angiogenic. Since tumor cell-derived TSP-1 has the potential to promote angiogenesis in the tumor microenvironment, it could be a potential target for breast cancer therapy.
Simplified frame structure for MMSE-based fastburst synchronisation inOFDM systems (1999)

A simplified frame structure is proposed for fast burst synchronisation in orthogonal frequency division multiplexing systems. A simpler and shorter synchronisation symbol and minimum mean square error algorithm is exploited to estimate the frame starting position. The performance of the proposed frame is confirmed by simulation for QPSK systems.
Eosinophil cationic protein cDNA. Comparison with other toxic cationic proteins and ribonucleases. (1989)

Human eosinophil granules contain several basic proteins including eosinophil cationic protein (ECP), eosinophil-derived neurotoxin (EDN) and major basic protein (MBP). ECP and MBP are potent helminthotoxins while EDN is less so. Both ECP and EDN possess neurotoxic and ribonuclease activities. A clone representing ECP mRNA was isolated from an eosinophil lambda ZAP cDNA library. The cDNA sequence codes for a preprotein of 160 amino acids and a protein of 133 amino acids, the amino terminus of which is identical to the known partial amino acid sequence of ECP. The ECP nucleotide sequence shows similarity to EDN, rat pancreatic ribonuclease, and human angiogenin; all are members of the ribonuclease gene superfamily. Although the deduced amino acid sequence of ECP shares identical active site and substrate binding site residues with EDN, angiogenin, and human pancreatic ribonuclease, the ribonuclease activity of ECP is 50 to 100 times less than that of EDN possibly because of the lack of a positively charged residue at human pancreatic ribonuclease position 122. The calculated isoelectric point (10.8), electronic charge (14.5), and cationic charge distribution of ECP are different from those of EDN but similar to those of MBP, which may account in part for the greater helminthotoxic activity of ECP when compared to EDN. These data suggest that ECP and EDN are derived from a common ancestral ribonuclease gene and that ECP has evolved into a potent helminthotoxin similar in some respects to MBP, while losing much of its ribonuclease activity.
Peanut allergy: a growing phenomenon (2003)

repressing our sodium transporters in our kidney, the frequency of salt-sensitive hypertension would have been even higher and hypertension even much more severe.
Extracellular Domain of the Transforming Growth Factor-β Receptor Negatively Regulates Ligand-independent Receptor Activation (1999)

We have previously proposed that transforming growth factor (TGF)-beta receptor activation occurs via a relative rotation between the receptors. This model suggests that in the absence of the ligand the receptor extracellular domain negatively regulates the activation of the receptor complex. To investigate this proposition, four TGF-beta type I and II receptor extracellular/transmembrane-cytoplasmic and extracellular-transmembrane/cytoplasmic chimeras, TbetaRII-I-I and TbetaRI-II-II as well as TbetaRII-II-I and TbetaRI-I-II, and two extracellular domain truncated receptors TbetaRI-STC and TbetaRII-STC were generated. In either mutant mink lung R1B (lacking functional type I receptor) or DR26 (where the type II receptor is nonfunctional) cells, coexpression of two chimeric receptors, which are complementary in extracellular and cytoplasmic domains, transduced TGF-beta induced signaling, as measured by the transcriptional activation of a p3TP-Lux reporter gene. Coexpression of this type of chimeric receptor with a wild-type receptor containing the opposite cytoplasmic domain exhibited a varied level of constitutive activity depending on the particular combination of the extracellular domains. In general, the type I-type I extracellular domain combination gave higher constitutive activity than the type I-type II or type II-type II combinations. Furthermore, coexpression of the extracellular domain truncated receptor with any receptor containing the opposite cytoplasmic domain always resulted in ligand independent receptor signaling. Immunoprecipitation studies showed that the formation of the receptor complexes paralleled the ligand independent activation of p3TP-Lux. Our results support the conclusion that the TGF-beta receptor extracellular domain plays a negative regulatory role in receptor activation in the absence of ligand.
Building a Practical Wi-Fi-Based Indoor Navigation System (2014)

This article presents the seven-step process involved in building a practical Wi-Fi-based indoor navigation system, which was implemented at the COEX complex in Seoul, Korea, in October 2010. The article describes the primary activities in each step using the COEX example. More than 200,000 users have downloaded the system since its first release. The successful launch of the COEX indoor navigation system suggests that indoor navigation is becoming a reality.
Control of tobacco bacterial wilt by an avirulent strain of Pseudomonas solanacearum M4S and its bacteriophage. (1990)

[in Japanese]
Case 18-1972 (1972)

Presentation of CaseA 68-year-old man was admitted to the hospital because of a pleural effusion.Beginning at the age of 20 years he had worked for three years as a stone cutter in a quarry without respiratory protection, and for the next 12 years he had made sand castings in an iron foundry. Repeated x-ray examinations of the chest were reported to show changes consistent with silicosis, and he had been dyspneic for an uncertain period. Seven years before admission a film of the chest was interpreted as showing tuberculosis; multiple sputum specimens and a scalene-lymph-node biopsy revealed no . . .
A NOVEL PERSPECTIVE INTO THE NEURONAL ENCODING ALONG THE RETINAL PATHWAY EMPLOYING TIME- FREQUENCY TRANSFORMATION: PART I — FOR OBJECT (2004)

This paper presents an innovative approach to investigate the information encoding taking place in the visual pathway, particularly the retinal pathway. Gabor time-frequency (TF) transformation is applied to the spatio-temporal spike trains from the layers of the retinal pathway, corresponding to input object stimuli varying in shape, orientation & distance. These spike trains are generated by employing simulation tools. Using the TF transformation, a methodology is evolved to analyze information encoding in terms of dominant harmonic variations. Statistical analysis of these variations and extrapolation reveal that the dominant harmonic variations can be encoded as multinomial (multivariate polynomial) functions. For the set of input stimuli considered, a bivariate polynomial encoding is observed with the order of the polynomial and its coefficients encoding the variations in amplitude of dominant harmonics. Analysis of encoding is carried out for both ‘within the layers’, like horizontal only and ‘across the layers’, the entire retinal pathway. The simulation results presented enunciate the findings. In the companion paper part II, neuronal encoding for chromatic information is analyzed on similar lines. After analyzing the neuronal color encoding process in part II, a generalized encoding scheme applicable to object shapes as well as color is proposed.
FSGAN: Subject Agnostic Face Swapping and Reenactment (2019)

We present Face Swapping GAN (FSGAN) for face swapping and reenactment. Unlike previous work, FSGAN is subject agnostic and can be applied to pairs of faces without requiring training on those faces. To this end, we describe a number of technical contributions. We derive a novel recurrent neural network (RNN)-based approach for face reenactment which adjusts for both pose and expression variations and can be applied to a single image or a video sequence. For video sequences, we introduce continuous interpolation of the face views based on reenactment, Delaunay Triangulation, and barycentric coordinates. Occluded face regions are handled by a face completion network. Finally, we use a face blending network for seamless blending of the two faces while preserving target skin color and lighting conditions. This network uses a novel Poisson blending loss which combines Poisson optimization with perceptual loss. We compare our approach to existing state-of-the-art systems and show our results to be both qualitatively and quantitatively superior.
Gestures as input: neuroelectric joysticks and keyboards (2003)

EMG (electromyogram) technology helps capture gestures as input for virtual joysticks and keyboards and thus could lead to new applications in flight control, space, and the video game industry.
A Comprehensive Survey and Classification of Approaches for Community Question Answering (2016)

Community question-answering (CQA) systems, such as Yahoo! Answers or Stack Overflow, belong to a prominent group of successful and popular Web 2.0 applications, which are used every day by millions of users to find an answer on complex, subjective, or context-dependent questions. In order to obtain answers effectively, CQA systems should optimally harness collective intelligence of the whole online community, which will be impossible without appropriate collaboration support provided by information technologies. Therefore, CQA became an interesting and promising subject of research in computer science and now we can gather the results of 10 years of research. Nevertheless, in spite of the increasing number of publications emerging each year, so far the research on CQA systems has missed a comprehensive state-of-the-art survey. We attempt to fill this gap by a review of 265 articles published between 2005 and 2014, which were selected from major conferences and journals. According to this evaluation, at first we propose a framework that defines descriptive attributes of CQA approaches. Second, we introduce a classification of all approaches with respect to problems they are aimed to solve. The classification is consequently employed in a review of a significant number of representative approaches, which are described by means of attributes from the descriptive framework. As a part of the survey, we also depict the current trends as well as highlight the areas that require further attention from the research community.
Dynamic test generation to find integer bugs in x86 binary linux programs (2009)

Recently, integer bugs, including integer overflow, width conversion, and signed/unsigned conversion errors, have risen to become a common root cause for serious security vulnerabilities. We introduce new methods for discovering integer bugs using dynamic test generation on x86 binaries, and we describe key design choices in efficient symbolic execution of such programs. We implemented our methods in a prototype tool SmartFuzz, which we use to analyze Linux x86 binary executables. We also created a reporting service, metafuzz.com, to aid in triaging and reporting bugs found by SmartFuzz and the black-box fuzz testing tool zzuf. We report on experiments applying these tools to a range of software applications, including the mplayer media player, the exiv2 image metadata library, and ImageMagick convert. We also report on our experience using SmartFuzz, zzuf, and metafuzz.com to perform testing at scale with the Amazon Elastic Compute Cloud (EC2). To date, the metafuzz.com site has recorded more than 2, 614 test runs, comprising 2, 361, 595 test cases. Our experiments found approximately 59 total distinct bugs in 864 compute hours, costing us an average of $2.93 per bug at current EC2 rates. We quantify the overlap in bugs found by the two tools, and we show that SmartFuzz finds bugs missed by zzuf, including one program where SmartFuzz finds bugs but zzuf does not. 1
Recompilation for debugging support in a JIT-compiler (2002)

A static Java compiler converts Java source code into a verifiably secure and compact architecture-neutral intermediate format, called Java byte codes. The Java byte codes can be either interpreted by a Java Virtual Machine or translated into native code by Java Just-In-Time compilers. Static Java compilers embed debug information in the Java class files to be used by the source level debuggers. However, the debug information is generated for architecture independent byte codes and most of the debug information is valid only when the byte codes are interpreted. Translating byte codes into native instructions puts a limitation on the amount of usable debug information that can be used by source level debuggers. In this paper, we present a new technique to generate valid debug information when Just-In-Time compilers are used. Our approach is based on the dynamic recompilation of Java methods by a fast code generator and lazily generates debug information when it is required. We also present three implementations for field watch support in the Java Virtual Machine Debugger Interface to investigate the runtime overhead and code size growth by our approach.
A New Device Preventing Air Embolism During the Angiography, Air Trap Device: An In-Vitro Experimental Air Emboli Study (2019)

Air embolism occurs when an air bubble enters the arterial system through the catheters. This can happen due to different reasons such as lack of attention, connection failure, or inexperience. This situation results in tissue damage in vital organs such as the heart and brain which may lead to death. To our knowledge, there is no technology preventing an air embolus from happening. Doctors try to prevent this complication with their attention and catheter control. In this project, a new air-trap device that prevents air embolus was tested in-vitro in air embolism model. Experimental results with a prototype showed that the new design was successful. Air embolism was blocked at various pressure-speed ranges. Air Trap device can be used to prevent air embolism by cardiologists, interventional radiologists and cardiovascular surgeons that perform a percutaneous intervention.
Faculty perceptions of the impact of student laptop use in a wireless Internet environment on the classroom learning environment and teaching (2019)

This study examines faculty perceptions of the impact of wireless laptops in the higher education classroom. A survey comprising Likert-scale and open-ended questions was administered to faculty members at a large public university. Survey questions focused on faculty perceptions of the impact of wireless laptops on the classroom atmosphere and their teaching. Depending on the context of use, respondents pointed to numerous ways in which laptops have enabled them to incorporate new information sources, engage students, and add activities to enhance classroom learning. A majority of respondents, however, indicated that students are likely to become distracted when using wireless laptops and that student participation in discussions can be negatively impacted. A majority also indicated that they would make use of an option to turn off Internet access in their classrooms.
Catalytic Asymmetric Intramolecular Michael Reaction of Aldehydes (2004)

Efficient organocatalysis of the intramolecular Michael reaction of formyl enones, such as 1, by an imidazolidinone catalyst leads to the corresponding ketoaldehydes in excellent yields and with high enantioselectivities (see scheme). This reaction can be included as part of a tandem process, as the ketoaldehyde products undergo aldolization readily to give hydrindenones, such as 2. Bn=benzyl, Ms=methanesulfonyl.
Long-wavelength nonequilibrium optical phonon dynamics in cubic and hexagonal semiconductors (2004)

We have investigated the relaxation of zone-center nonequilibrium optical phonons in bulk cubic and hexagonal semiconductors. Our theory is based on the application of Fermi's golden rule formula involving anharmonic interaction between phonons. Calculations of the lifetimes of the zone-center longitudinal optical (LO) and transverse optical (TO) phonons in cubic materials have been performed by modeling acoustic phonon modes within Debye's isotropic continuum scheme. Lifetimes of ${A}_{1}(\mathrm{LO})$, ${E}_{1}(\mathrm{TO})$, ${A}_{1}(\mathrm{TO})$, ${E}_{2}^{2}$ and ${E}_{2}^{1}$ modes in wurtzite semiconductors have also been calculated by employing Debye's scheme within a semi-isotropic continuum model for acoustic modes. We have obtained a few trends in the lifetime results within a crystal phase (cubic or hexagonal), and between the two crystal phases. Our results support and explain available experimental data over a large temperature range, and make some predictions.
Improving cervical cancer screening in Mexico: results from the Morelos HPV Study (2003)

Our results suggest that self- and clinician-collected HPV testing could be used in CC prevention programs, as an effective complement or substitute for the Pap test. This paper is available too at: http://www.insp.mx/salud.index.html.
Enhancement of Low Dynamic Range Videos using High Dynamic Range Backgrounds (2011)

In this paper, we present a practical system for enhancing the quality of Low Dynamic Range (LDR) videos using High Dynamic Range (HDR) background images. Our technique relies on the assumption that the HDR information is static in the video footage. This assumption can be valid in many scenarios where moving subjects are the main focus of the footage and do not have to interact with moving light sources or highly reflective objects. Another valid scenario is teleconferencing via webcams, where the background is typically over-exposed, not allowing the users to perceive correctly the environment where the communication is happening.
Synthesis of Functionalized 1H-Pyrazolo[4,3-e][1,2,4]triazines and Their Fused Derivatives via Ipso-Substitution of Methylsulfonyl Group with O-, N-, S- and C-Nucleophiles (2004)

Ipso-substitution reaction of 3-methyl-5-methylsulfonyl-1-phenyl-1H-pyrazolo[4,3-e][1,2,4]triazine (4) with a range of C-, N-, Oand S-nucleophiles afforded the corresponding substitution products (5a-m) in high
ChemInform Abstract: Amine(imine)diphosphine Iron Catalysts for Asymmetric Transfer Hydrogenation of Ketones and Imines. (2014)

Abstract The synthesis of novel enantiopure amine(imine)diphosphine catalysts that take advantage of the iron(II) ion as a template is described.
Traceability and Provenance in Big Data Medical Systems (2015)

Providing an appropriate level of accessibility to and tracking of data or process elements in large volumes of medical data, is an essential requirement in the Big Data era. Researchers require systems that provide traceability of information through provenance data capture and management to support their clinical analyses. We present an approach that has been adopted in the neuGRID and N4U projects, which aimed to provide detailed traceability to support research analysis processes in the study of biomarkers for Alzheimer's disease, but is generically applicable across medical systems. To facilitate the orchestration of complex, large-scale analyses in these projects we have adapted CRISTAL, a workflow and provenance tracking solution. The use of CRISTAL has provided a rich environment for neuroscientists to track and manage the evolution of data and workflow usage over time in neuGRID and N4U.
Assessment of Vaccine-Induced CD4 T Cell Responses to the 119-143 Immunodominant Region of the Tumor-Specific Antigen NY-ESO-1 Using DRB1*0101 Tetramers (2010)

The development of DR1/ESO(119-143) tetramers, allowing the direct visualization, isolation, and characterization of ESO-specific CD4 T cells, will be instrumental for the evaluation of spontaneous and vaccine-induced immune responses to this important tumor antigen in DR1-expressing patients.
Modeling of Lithium Plating in Lithium-Ion Batteries (2010)

Abstract not Available.
Attenuated induction of heat shock gene expression in aging diploid fibroblasts (1989)

We examined the effects of cellular aging on the regulation of heat shock gene expression in IMR-90 human diploid fibroblasts. Heat shock (42-43 degrees C) and canavanine (200-400 micrograms/ml) were used to evoke the heat shock response in these cells. We showed that heat shock induced the synthesis of proteins with apparent molecular weights of 98,000, 89,000, 78,000, 72,000, 64,000, 50,000 and 25,000, with heat shock protein (HSP) 89 and 72 being most prominent. Canavanine induced the synthesis of the four high molecular weight HSPs, particularly HSP 89 and HSP 78, without noticeably enhancing synthesis of the low molecular weight HSPs. We found that, while a similar series of HSPs were induced in the young and old cells, there was a marked decrease in the magnitude of this induction in the old cells. Using cells with defined population doubling levels, we observed a direct correlation of the inducibility of HSP synthesis and the replicative potential of the cells used. Analysis of the amount of translatable and hybridizable mRNA, by the methods of in vitro translation and Northern blot hybridization, demonstrated that the induction of HSPs synthesis can be accounted for by increases in their mRNA. Nuclear runoff transcription provided evidence that the decrease in inducible expression of the HSPs in aging IMR-90 cells was attributable to a transcriptional mechanism. This conclusion was substantiated by analysis of the hsp 70 promoter activity in transient expression assay of the hsp 70 promoter-chloramphenicol acetyltransferase construct. We propose that there is an age-associated dysfunction in the signaling mechanism of the heat shock response.
C. elegans : a practical approach (1999)

Gout is associated with increased risk for clinical heart failure, subclinical measures of systolic dysfunction and mortality.
An Interactive System for Chinese Character Generation and Retrieval (1973)

An interactive system for the generation and editing of Chinese texts using a small computer and a low-cost graphic display device is described. A unified structural approach is taken for character generation, character retrieval, and the defining of new characters. It is estimated that character-retrieval rates of the order of 30 characters per minute may be attained with this system. The system is suitable for use by persons having a working knowledge of Chinese.
Navigation issues in hypertext (1997)

Article Navigation issues in hypertext: documenting complex hierarchies with HTML frames Share on Author: Michael Priestley IBM Toronto Laboratory IBM Toronto LaboratoryView Profile Authors Info & Claims SIGDOC '97: Proceedings of the 15th annual international conference on Computer documentationOctober 1997 Pages 223–235https://doi.org/10.1145/263367.263396Online:01 October 1997Publication History 1citation378DownloadsMetricsTotal Citations1Total Downloads378Last 12 Months3Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access