gebhart/patrepeval huggingface dataset:
The conserved bromo-adjacent homology domain of yeast Orc1 functions in the selection of DNA replication origins within chromatin (2010)

The origin recognition complex (ORC) binds to the specific positions on chromosomes that serve as DNA replication origins. Although ORC is conserved from yeast to humans, the DNA sequence elements that specify ORC binding are not. In particular, metazoan ORC shows no obvious DNA sequence specificity, whereas yeast ORC binds to a specific DNA sequence within all yeast origins. Thus, whereas chromatin must play an important role in metazoan ORC's ability to recognize origins, it is unclear whether chromatin plays a role in yeast ORC's recognition of origins. This study focused on the role of the conserved N-terminal bromo-adjacent homology domain of yeast Orc1 (Orc1BAH). Recent studies indicate that BAH domains are chromatin-binding modules. We show that the Orc1BAH domain was necessary for ORC's stable association with yeast chromosomes, and was physiologically relevant to DNA replication in vivo. This replication role was separable from the Orc1BAH domain's previously defined role in transcriptional silencing. Genome-wide analyses of ORC binding in ORC1 and orc1bahDelta cells revealed that the Orc1BAH domain contributed to ORC's association with most yeast origins, including a class of origins highly dependent on the Orc1BAH domain for ORC association (orc1bahDelta-sensitive origins). Orc1bahDelta-sensitive origins required the Orc1BAH domain for normal activity on chromosomes and plasmids, and were associated with a distinct local nucleosome structure. These data provide molecular insights into how the Orc1BAH domain contributes to ORC's selection of replication origins, as well as new tools for examining conserved mechanisms governing ORC's selection of origins within eukaryotic chromosomes.
Endotoxemia—menace, marker, or mistake? (2016)

Endotoxemia is in its scientific ascendancy. Never has blood-borne, Gram-negative bacterial endotoxin (LPS) been invoked in the pathogenesis of so many diseases-not only as a trigger for septic shock, once its most cited role, but also as a contributor to atherosclerosis, obesity, chronic fatigue, metabolic syndrome, and many other conditions. Finding elevated plasma endotoxin levels has been essential supporting evidence for each of these links, yet the assays used to detect and quantitate endotoxin have important limitations. This article describes several assays for endotoxin in plasma, reviews what they do and do not measure, and discusses why LPS heterogeneity, LPS trafficking pathways, and host LPS inactivation mechanisms should be considered when interpreting endotoxin assay results.
Synthesis of poly(vinylidene fluoride) (PVdF)/silica hybrids having interpenetrating polymer network structure by using crystallization between PVdF chains (2005)

Abstract High transparent and homogeneous poly(vinylidene fluoride) (PVdF)/silica hybrids were obtained by using an in‐situ interpenetrating polymer network (IPN) method. The simultaneous formation of PVdF gel resulting from the physical cross‐linking and silica gel from sol–gel process prevented the aggregation of PVdF in silica gel matrix. To form the physical cross‐linking between PVdF chains, the cosolvent system of dimethylformaide (DMF) and γ‐butyrolactone was used. The obtained PVdF/silica hybrids had an entangled combination of physical PVdF gel and silica gel, which was called a “complete‐ IPN” structure. The physical cross‐linking between PVdF chains in silica gel matrix was confirmed by differential scanning calorimetry (DSC) measurements. The miscibility between PVdF and silica phase was examined by scanning electron microscopy (SEM) and tapping mode atomic force microscopy (TM‐AFM) measurements. © 2005 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 43: 3543–3550, 2005
Application of high and low frequency ultrasonography in diagnosis of acute abdominal disease (2010)

Objective To evaluate the diagnostic value of high and low frequency ultrasonography in diagnosis of acute abdominal disease. Methods One hundred and thirty patients of acute abdominal disease were examined by high and low frequency ultrasonography. The patients were proved by clinical diagnosis. Results In 130 patients of acute abdominal disease,126 patients'ultrasound diagnosis were accurate, the diagnositic accuracy rate was 96.9%. Four patients' ultrasound diagnosis were not accurate,the diagnositic error rate was 3.1%. Conclusions High and low frequency ultrasonography have important value in diagnosis of acute abdominal disease.

Key words: 
Ultrasonography; Acute abdominal disease
A software radio testbed for two-transmitter two-receiver space-time coding OFDM wireless LAN (2004)

A real-time testbed based on the technology of software radio is adopted to efficiently evaluate cutting-edge technologies in wireless communications, and thus becomes a valuable tool for both academic research and system prototyping. In this article we describe a software radio testbed, established in the software radio laboratory at Georgia Institute of Technology, used to implement a physical layer similar to IEEE 802.11a space-time coded orthogonal frequency-division multiplexing. The testbed consists of a 2 x 2 multiple-input multiple-output configuration with powerful digital signal processor chains, high-speed data exchange interfaces, and many advanced subsystem modules, such as high-speed high-resolution analog-to-digital and digital-to-analog converters, digital up/downconverters, and wideband RF transmit and receive front-ends with synchronous channels and programmable settings. The design methodology and implementation for key algorithms, such as time, sampling, and frequency synchronization, and channel estimation and compensation are discussed. The experimental data obtained from a typical indoor environment demonstrates that the prototype is capable of providing 30 Mb/s peak data rate, operating at the central frequency of 2.435 GHz with a spectral occupancy of 6.25 MHz. Spatial-temporal diversity gain associated with space-time coding is verified by the experimental results.
Asymmetric Fluorination of Enolates with Nonracemic <i>N</i>-Fluoro-2,10-Camphorsultams (1998)

The asymmetric “electrophilic” fluorination of tertiary enolates by nonracemic N-fluoro-2,10-camphorsultams 3 affords quaternary α-fluoro carbonyl compounds in modest yield and ee. The highest asymmetric induction was observed for the fluorination of the sodium enolate of 2-methyl-1-tetralone (8a) by (−)-N-fluoro-2,10-(3,3-dichlorocamphorsultam) (3b) to give (S)-(+)-2-fluoro-2-methyl-1-tetralone (9a) in 70% ee. The absolute configuration was established by X-ray crystallography of the corresponding diastereomeric β-hydroxy sulfoximine prepared from (±)-9a and the Johnson reagent. The asymmetric induction exhibited by 3 is opposite to that of the closely related enolate hydroxylation reagents nonracemic (camphorylsulfonyl)oxaziridines 4. The N-fluoro sultams 3 were prepared by fluorination (10% F2/N2) of the corresponding sultams 5.
Electrical resistivity tomography of vadose water movement (1992)

Cross borehole electrical resistivity tomography (ERT) was used to image the resistivity distribution before and during two infiltration experiments. In both cases water was introduced into the vadose zone, and the change in resistivity associated with the plume of wetted soil was imaged as a function of time. The primary purpose of this work was to study the capabilities and limitations of ERT to image underground structure and ground water movement in the vadose zone. A secondary goal was to learn specifics of unsaturated flow in a complex geologic setting. Tomographs of electrical resistivity taken before infiltration image coarser, well‐drained soils (sands and gravels) as more resistive zones, whereas finer grained soils (silts and clays), which hold more water by capillarity, are imaged as more conductive. Images of changes in resistivity during infiltration show growth of the water infiltration plume with time that is consistent with known geology. In the ERT images we see the effects of capillary barriers and infer differences between capillary‐driven flow through fine sediments and gravity‐driven flow through very permeable sediments. Images are consistent with numerical flow simulations using hydrological parameter values consistent with soil types inferred from well logs. ERT can be a useful tool to monitor movement of circuitous moisture fronts in a heterogeneous field setting that would go undetected by borehole measurements.
Untersuchungen zum Verschleiß hochtonerdehaltiger Feuerfestmaterialien für die Pfannenmetallurgie im Stahlwerksbetrieb (2002)

In Rahmen der vorliegenden Arbeit wurde die Charakterisierung einer hochtonerdehaltigen Feuerfestmasse mit Spinellzusatz vorgenommen. Es wurde eine weitgehende Übereinstimmung bei der Untersuchung der Feuerfestmasse unter Labor- und Betriebsbedingungen gefunden und die ermittelten Ergebnisse konnten auf reale Betriebsbedingungen übertragen werden. Das im Rahmen der Arbeit erarbeitete Programm zur Vorhersage der Zustellungshaltbarkeit nach bestimmten Chargenzahlen führt zur Optimierung der Einsatzplanung und Reparaturdurchführung und kann für die Kontrolle der Pfannenverfügbarkeit im Stahlwerk herangezogen werden.
Increased nitrite reductase activity of fetal versus adult ovine hemoglobin (2008)

Growing evidence indicates that nitrite, NO2-, serves as a circulating reservoir of nitric oxide (NO) bioactivity that is activated during physiological and pathological hypoxia. One of the intravascular mechanisms for nitrite conversion to NO is a chemical nitrite reductase activity of deoxyhemoglobin. The rate of NO production from this reaction is increased when hemoglobin is in the R conformation. Because the mammalian fetus exists in a low-oxygen environment compared with the adult and is exposed to episodes of severe ischemia during the normal birthing process, and because fetal hemoglobin assumes the R conformation more readily than adult hemoglobin, we hypothesized that nitrite reduction to NO may be enhanced in the fetal circulation. We found that the reaction was faster for fetal than maternal hemoglobin or blood and that the reactions were fastest at 50-80% oxygen saturation, consistent with an R-state catalysis that is predominant for fetal hemoglobin. Nitrite concentrations were similar in blood taken from chronically instrumented normoxic ewes and their fetuses but were elevated in response to chronic hypoxia. The findings suggest an augmented nitrite reductase activity of fetal hemoglobin and that the production of nitrite may participate in the regulation of vascular NO homeostasis in the fetus.
Acupuncture: Textbook and Atlas (1987)

Acupuncture : textbook and atlas , Acupuncture : textbook and atlas , کتابخانه دیجیتال جندی شاپور اهواز
A high bandwidth radar target simulator for automotive radar sensors (2016)

In this paper, the construction of a modular target simulator for automotive radar sensors is described. Using a fully analog design, the simultaneous covering of all E-band automobile radar bands is possible. Static scenarios and moving targets with realistic parameters can be simulated.
Synthesising clinically realistic Chest X-rays using Generative Adversarial Networks (2020)

Chest x-rays are one of the most commonly performed medical investigations globally and are vital to identifying a number of conditions. These images are however protected under patient confidentiality and as such require the removal of identifying information as well as ethical clearance to be released. Generative adversarial networks (GANs) are a branch of deep learning which are capable of producing synthetic samples of a desired distribution. Image generation is one such application with recent advances enabling the production of high-resolution images, a feature vital to the utility of x-rays given the scale of various pathologies. We apply the Progressive Growing GAN (PGGAN) to the task of chest x-ray generation with the goal of being able to produce images without any ethical concerns that may be used for medical education or in other machine learning work. We evaluate the properties of the generated x-rays with a practicing radiologist and demonstrate that high-quality, realistic images can be produced with global features consistent with pathologies seen in the NIH dataset. Improvements in the reproduction of small-scale details remains for future work. We train a classification model on the NIH images and evaluate the distribution of disease labels across the generated samples. We find that the model is capable of reproducing all the abnormalities in a similar proportion to the source image distribution as labelled by the classifier. We additionally demonstrate that the latent space can be optimised to produce images of a particular class despite unconditional training, with the model producing related features and complications for the class of interest. We also validate the application of the Fr'echet Inception Distance (FID) to x-ray images and determine that the PGGAN reproduces x-ray images with an FID of 8.02, which is similar to other high resolution tasks.
Propellant/Material Compatibility Study (1971)

The objective of this program was to define the threshold sensitivity limit of hydrazine fuels in common metallic materials of construction as a function of temperature and pressure. Four propellants were included in the program: hydrazine, monomethylhydrazine, MHF-5, and MHF-7. Eleven metallic materials of construction were included in the program: stainless steel 304L, 316, 321, 347, and 17-7PH; aluminum 1100-0, 6061-T6, and 2014-T6; Inconel-X 750; Haynes-25; and Hastelloy-X. Three standard tests were used to determine the threshold sensitivity limit of the propellants in the various materials: thermal stability test, detonation propagation test, and U-tube adiabatic compression test.
Implementation and Evaluation of Network Interface and Message Passing Services for TianHe-1A Supercomputer (2011)

TianHe-1A, a large scale supercomputer features hybrid multi-core CPU and GPU computing, utilizes a proprietary high-bandwidth, low-latency interconnect fabric to achieve the optimized balance of computation and communication capabilities. In this paper, we describe the design of the network interface in TianHe-1A which supports user-level communication and offloads collective operation to deliver communication performance close to the hardware limits. Scalable and high performance message passing services are implemented on this interface and preliminary performance results are provided.
Tooth polishing: The current status (2015)

Healthy teeth and gums make a person feel confident and fit. As people go about their daily routines and with different eating and drinking habits, the tooth enamel turns yellowish or gets stained. Polishing traditionally has been associated with the prophylaxis procedure in most dental practices, which patients know and expect. However, with overzealous use of polishing procedure, there is wearing of the superficial tooth structure. This would lead to more accumulation of local deposits. Also, it takes a long time for the formation of the fluoride-rich layer of the tooth again. Hence, now-a-days, polishing is not advised as a part of routine oral prophylaxis procedure but is done selectively based on the patients' need. The article here, gives an insight on the different aspects of the polishing process along with the different methods and agents used for the same.
Breeding of Mice Strains for Diabetes Mellitus (1969)

実験動物育種の立場から糖尿病マウス系統の育成を目標とし, 既存の11系統の中から, 尿糖, 非絶食時血糖, 糖負荷試験による適応試験によって目標に沿う系統を探し, 更に重症の糖尿病マウスを得るための育種操作を行なった。KK系の糖尿病症状及びAy遺伝子の糖尿病効果を確認すると共に, 適応試験によりカスカベ及びニシキネズミグループに糖尿病傾向が広く認あられた。すなわちKSB系が雌において尿糖陽性, 両性においてKKと同じく高血糖, 糖処理能力劣弱を示し, またNC, NB, NBC, DDK系も糖処理能力劣弱を示した。次に, Ay遺伝子をKK系に導入することにより, Congenicstrain, KK-CAyを育成し, 発症率の高い, 激しい持続的尿糖と高血糖及び糖処理能力劣弱を呈する重症の糖尿病系統を得ることができた。一方, KK系とKSB系の交雑から重症化へのSele-ctionを行ない, F3世代において既に有意義な糖処理能力劣弱への選抜効果を認めた。しかし著しい繁殖力減退を伴ったため系統として固定するには至らなかった。
Preparation, Structure, and Electrochemical Properties of Reduced Graphene Sheet Films (2009)

Abstract This paper describes the preparation, characterization, and electrochemical properties of reduced graphene sheet films (rGSFs), investigating especially their electrochemical behavior for several redox systems and electrocatalytic properties towards oxygen and some small molecules. The reduced graphene sheets (rGSs) are produced in high yield by a soft chemistry route involving graphite oxidation, ultrasonic exfoliation, and chemical reduction. Transmission electron microscopy (TEM), X‐ray diffraction (XRD), scanning electron microscopy (SEM), X‐ray photoelectron spectroscopy (XPS) and Raman spectroscopy clearly demonstrate that graphene was successfully synthesized and modified at the surface of a glassy carbon electrode. Several redox species, such as Ru(NH 3 ) 6 3+/2+ , Fe(CN) 6 3−/4− , Fe 3+/2+ and dopamine, are used to probe the electrochemical properties of these graphene films by using the cyclic voltammetry method. The rGSFs demonstrate fast electron‐transfer (ET) kinetics and possess excellent electrocatalytic activity toward oxygen reduction and certain biomolecules. In our opinion, this microstructural and electrochemical information can serve as an important benchmark for graphene‐based electrode performances.
Object-oriented rapid prototyping (1989)

1. Basics. 2. Terms. 3. Objects. 4. Tools. 5. Development. 6. Refinement. 7. Evolution. 8. Life-Cycles. 9. Experience. 10. Projects. 11. CASE. 12. Documentation. 13. Startup.
A Wireless Based Real-time Patient Monitoring System (2011)

Abstract- The paper demonstrated gives the complete idea on a system which uses four smart sensors to detect the respective four pathological parameters of a baby or a person and interfacing the cell phone to this system to alarm the doctors. The smart sensors senses the biomedical signal of the subject under study (here subject means a baby or a person with pathological disorders) and executes with the controlled coding of the mother processor that is microcontroller and further it hooks the wireless cell phone and using the application software, TEXT application protocol of the cell phone to alarm the respective doctors. With this idea to save energy by consuming the cell phone battery and to help out people below poverty line to contact experienced doctors, who are out of reach and they by analysis is done perfectly. No external source is used for triggering the alarm. Using wireless-based low cost to monitor real-time pathological parameters of the subject and say it as a simple biomedical-caring system. The system keeps an extra eye on the pathological parameters of subject under test/babies at home/ICU. The intelligent system consists of detector circuit and mobile display unit at the receiver section. The detector circuit uses different application sensors to detect health condition of the subject at the source. The mobile display unit is used to visualize the health situation by using the text based application on the cell phones by a doctor or concerned person. The standard for mobile telephony that has been used in this project is wireless communication. The ubiquity of implementation of the wireless standard has been an advantage to both consumers, who may benefit from the ability to roam and switch carriers without replacing phones, and also to network operators, who can choose equipment from many wireless equipment vendors. Wireless also pioneered low-cost implementation of the short message service (SMS), also called text messaging, which has since been supported on other mobile phone standards as well. The standard includes a worldwide emergency telephone number feature. So, the main aim of this project is to get information about the condition of the critical subject which
Simulation of flow and heat transfer in diesel particulate filter (2008)

Particulate matters (PM) including soot in diesel exhaust gas are severe environmental problems. It is expected that emission of soot particles can penetrate into the lung, causing human carcinogenic effects. To reduce these emissions especially from heavy-duty vehicles such as cargo trucks and buses, a diesel particulate filter (DPF) has been developed for the after-treatment of exhaust gas. In simple explanation of DPF, it traps PM when exhaust gas passes its porous wall. However, since the filter would be plugged with particles to cause an increase of filter back-pressure, filter regeneration process is needed. In this study, we simulate the flow in DPF by the lattice Boltzmann method (LBM). So far, the LBM has been widely used in fluid simulation, and has been an alternative and promising numerical scheme. It has been confirmed that, through the Chapman-Enskog procedure, the Navier-Stokes equations are derived from LB equations. In the LBM, the treatment of boundary conditions is simple and easy, and it is appropriate to simulate porous media flows such as DPF. In this paper, our approach for LB simulation of combustion is briefly explained. Here, the real filter is used in the simulation. The inner structure of the filter sample is scanned by a 3D X-ray CT technique. By conducting tomography-assisted simulation, we obtain local velocity and pressure distributions in the filter, which is hardly obtained by measurements. First, the flow and pressure profiles are visualized, compared with the empirical equation of the Ergun equation. Then, the soot combustion is simulated. Based on the temperature change and reaction inside the filter, the heat and mass transfer in the filter regeneration process is discussed.
Evaluation of curved crystals for cosmic x-ray spectroscopy (1995)

We describe a spectrometer used to evaluate curved crystals, crystals originally intended for cosmic x-ray spectroscopy on the AXAF satellite. The most important feature of the AXAF instrument was the high-resolution spectra (λ/Δλ as high as 2000) that could be obtained from astronomical objects over the λ range 1.2 to 100 A. The crystals are formed into narrow cylindrical facets and assembled into a pseudotoroidal surface. The spectral resolution is degraded by a number of effects, which we describe. The primary effect over which we have control is the figure of each cylindrical segment. We measure deviations from the nominal cylindrical shape, which we call Δθ slope using a laboratory x-ray spectrometer. We present spectrometer data for several crystal samples, evaluated at different energies. We compare these results with similar tests performed at optical wavelengths. Our results indicate that the Δθ slope error can be controlled, and that curved crystals with the desired resolving power can be fabricated.
Thermal expansion coefficient and thermomechanical properties of SiN<sub>x</sub> thin films prepared by plasma-enhanced chemical vapor deposition (2012)

We present a new method based on fast Fourier transform (FFT) for evaluating the thermal expansion coefficient and thermomechanical properties of thin films. The silicon nitride thin films deposited on Corning glass and Si wafers were prepared by plasma-enhanced chemical vapor deposition in this study. The anisotropic residual stress and thermomechanical properties of silicon nitride thin films were studied. Residual stresses in thin films were measured by a modified Michelson interferometer associated with the FFT method under different heating temperatures. We found that the average residual-stress value increases when the temperature increases from room temperature to 100°C. Increased substrate temperature causes the residual stress in SiN(x) film deposited on Si wafers to be more compressive, but the residual stress in SiN(x) film on Corning glass becomes more tensile. The residual-stress versus substrate-temperature relation is a linear correlation after heating. A double substrate technique is used to determine the thermal expansion coefficients of the thin films. The experimental results show that the thermal expansion coefficient of the silicon nitride thin films is 3.27×10(-6)°C(-1). The biaxial modulus is 1125 GPa for SiN(x) film.