gebhart/patrepeval huggingface dataset:
In vivo models of arterial thrombosis and thrombolysis (1990)

This year approximately 1.5 million Americans will undergo a myocardial infarction (MI). Of those who make it to the hospital (approximately 1.2 million), only about 20% will receive thrombolytic therapy. Multiple factors contribute to this dismaying figure, but most of them are risk/benefit-related. Moreover, of those receiving lytic therapy, the coronary arteries of as many as one-third may not reopen, and of those that do undergo coronary thrombolysis, an unacceptable fraction will experience reocclusion acutely. Thus, despite significant progress, major challenges for antithrombotic and thrombolytic therapy remain. Promising results with aspirin provide some hope that the figures above can be altered favorably. Efforts are under way in industry and academia to develop drugs to accomplish one or more of the following: lower the incidence of MI, prevent the development of unstable angina or retard its progression to frank MI, increase the inclusion window for lytic therapy, raise the percentage of patients undergoing successful thrombolysis, and maintain coronary patency. During the period that thrombolytic agents have come into vogue important advances have been made in our understanding of platelet function, coagulation, and the endogenous fibrinolytic system. These have spurred the development of novel drugs, such as platelet fibrinogen receptor antagonists, plasminogen activators, and inhibitors of factor IIa (thrombin) and XIIIa. Evaluation of these agents for their antithrombotic or profibrinolytic activity requires relevant animal models of thrombosis. Despite appropriate concerns about their clinical relevance, these models bridge the wide gap between test tube assays of aggregation or coagulation and humans.
Three dimensional freeform sculpting via zero sets of scalar trivariate functions (1999)

This paper presents a three dimensional interactive sculpting paradigm that employs a collection of scalar uniform trivariate Bspline functions.
A Network Virtualization Approach in Many-core Processor Based Cloud Computing Environment (2011)

With benefits of Cloud Computing widely acknowledged more and more public and private Cloud deployed. Virtualization is one of the most important supporting technologies for Cloud. While main stream CPUs are marching to many-core architecture the performance improvement of virtualization on many-core processor platform is critical for future Cloud. This paper presents an approach to implement network virtualization on many-core processor platform. The approach uses processor core to control all network interfaces and handle all packets from the interfaces. The core reschedules packets to corresponding operating system or other processor cores. This approach use a bare metal runs on a core to replace the low efficiency hypervisor and all operating systems can run in native mode rather than application mode on hypervisor. The theoretical analysis and tentative results show this approach can improve system performance up to around 20%.
Pentamidine uptake in <i>Leishmania donovani</i> and <i>Leishmania amazonensis</i> promastigotes and axenic amastigotes (1996)

A transport system for pentamidine in Leishmania donovani and Leishmania amazonensis promastigotes and axenic amastigotes has been identified and characterized. Pentamidine is not metabolized by these parasites. Its uptake process is saturable, carrier-mediated and energy-dependent. This drug does not inhibit purine or pyrimidine uptake, whereas it inhibits uptake of several amino acids non-competitively and that of putrescine and spermidine competitively. The results suggest that pentamidine shares polyamine-carrier systems in these parasites.
Glutamate oxidation by trophoblasts in vitro (1994)

Catabolism of uniformly and 1-14C-labeled glutamate was investigated in human placental cytotrophoblasts and syncytiotrophoblasts cultured on uncoated plastic or a fibrin matrix. Product-labeling experiments resulted in 14C incorporation into carbon dioxide and tricarboxylic acid cycle intermediates. 14C incorporation above background was not detected for the putative products, glutamine, amino acids, glutathione, and protein. Inhibitors of specific metabolic pathways were used to elucidate the routes of glutamate oxidation. Incorporation of 14C into carbon dioxide from [1-14C]glutamate was inhibited by the glutamate dehydrogenase inhibitor pyridine-2,6-dicarboxylic acid and aminotransferase inhibitor aminooxyacetic acid. Production of 14CO2 was higher for syncytiotrophoblast compared with cytotrophoblast and for cells on uncoated plastic compared with a fibrin matrix. Oxidation of glutamate was unaffected by added glutamine as high as 2 mM. The primary route of glutamate metabolism by placental trophoblast in vitro is oxidation to carbon dioxide utilizing both the transferase and deamination pathways.
Benefits and risks of rapid initiation of antiretroviral therapy (2017)

Accelerated ART initiation can lead to improved clinical outcomes and is likely to be of particular benefit in those settings where extensive patient preparation prior to starting ART results in long delays. These findings informed a WHO recommendation supporting accelerated ART initiation, including same day ART start.
Self-powered piezoelectric energy harvesting device using velocity control synchronized switching technique (2010)

With the rapid development of low power consumption electronics, wireless sensor networks (WSN) are highly investigated and used to improve our life quality. Using piezoelectric materials to transfer the mechanical energy into electrical energy for batteries of WSN in order to extend the life time is the focus in many researches in the recent years. It is important and efficient to improve the energy harvesting by designing an optimal interface between piezoelectric device and the load. In this paper, a self-powered piezoelectric energy harvesting device is proposed based on the velocity control synchronized switching technique (V-SSHI). Comparing to diode full bridge rectifier standard technique, the synchronized switching harvesting on inductor (SSHI) technique can highly improve harvesting efficiency. However, in real applications when the energy harvesting device is associated with WSN, the SSHI technique needs to be implemented and requires being self-powered. The conventional technique to implement the self-powered SSHI is to use bipolar transistor as voltage peak detector. In this paper, a new self-powered device is proposed, using velocity control to switch the MOSFET more accurately than in the conventional technique. The concept of design and theoretical analysis is presented in detail. Experimental results are examined and show better performance.
Behavior of Piezoresistive Smart Cement Contaminated with Oil Based Drilling Mud (2014)

Abstract As deep-water exploration and production of oil and gas expands around the world, there are unique challenges in well construction beginning at the seafloor. There are several benefits in using oil based drilling mud (OBM) in drilling operations but there are concerns about the potential contamination of the cement and have severe impact on cement performance in the wellbores. Recent case studies on cementing failures have clearly identified some of these issues that resulted in various types of delays in the cementing operations. For a successful cementing operation, it is critical to determine the contamination of cement during the installation so that necessary remediation can be made to minimize the effect. At present there is no technology available to monitor cementing operations and also to determine the potential of contamination in real time during the installation of the oil and gas wells. In this study well cement was modified to have better sensing properties, smart cement, so that its behavior can be monitored at various stages of construction and during the service life of wells. A series of experiments evaluated the smart well cement behavior with and without OBM to determine the sensitivity the electrical resistivity of cement to determine the level of contamination. Electrical resistivity was used as a monitoring tool to capture the contamination of cement with up to 3 percent OBM. The test results showed that mud contamination increased the electrical resistivity of the slurries based on the level of contamination. The OBM contamination also affected the rheological properties, setting characteristics and also reduced the compressive strength and the piezoresistive properties of the smart cement. The changes in the rheological properties were correlated to the level of contamination. A linear correlation was obtained between the 24-hour change in electrical resistivity and the compressive strength of the contaminated and uncontaminated cement based on the curing time.
Prevalence of mastitis: conversation between student and supervisor (2003)

In this conversation the definitions of mastitis, incidence and prevalence are discussed. (non-author abstract)
Severely impaired cerebrovascular reserve in patients with cerebral proliferative angiopathy (2011)

This study demonstrated severely impaired cerebrovascular reserve in the perilesional brain tissue surrounding the abnormal vessels of patients with CPA. This finding may provide an additional means to distinguish CPA from classic brain AVMs.
Isolation and Characterization of Isogenic Pairs of Domed Hemolytic and Flat Nonhemolytic Colony Types of <i>Bordetella pertussis</i> (1982)

Four different serotype strains of Bordetella pertussis, 3779BL(2)S(4), Tohama I, 353/Z, and 2753, were plated on Bordet-Gengou agar, where they grew as domed, hemolytic (D(+)H(+)) wild-type colonies. Cloned D(+)H(+) colony types of all four strains were passed onto modified Stainer-Scholte medium solidified with 1% Noble Agar. Colonies were selected from Stainer-Scholte agar, and these subsequently grew as flat, nonhemolytic (D(-)H(-)) colonies when transferred back onto Bordet-Gengou agar. The frequency of D(-)H(-) organisms within a population of cloned D(+)H(+) was determined to be between 5 x 10(-5) and 5 x 10(-6). The D(-)H(-) colony types maintained their flat, nonhemolytic characteristics for over 80 single-colony passages on Bordet-Gengou agar. The isogenic pairs of D(+)H(+) and D(-)H(-) colony types from the four strains were compared for hemagglutination titer, lymphocytosis-promoting activity, adenylate cyclase activity, and presence of agglutinogens by agglutination. In all cases the D(-)H(-) colony types showed reduced activities or amounts of antigen compared with their D(+)H(+) parents. Freely diffusible antigens were markedly different between the two phenotypes as noted by double diffusion of antisera added to plates on which colonies of the variants were growing. Antigens solubilized from the two colony types by Triton X-100 were also markedly different as judged by radial immunodiffusion with antifimbrial hemagglutinin, antilymphocytosis-promoting factor, and anti-353/Z adsorbed with autoclaved 353/Z. In addition, autoradiographs of (125)I-surface-labeled whole cells separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis revealed unique banding patterns for each colony type. Since all organisms, regardless of colony type, were grown on Bordet-Gengou agar, the differences reported could not be due to medium composition. Differences between phenotypes were also independent of passage number on Bordet-Gengou agar. By analogy to previous studies, the D(-)H(-) organisms appear to fulfill the criteria for phase III or phase IV in the system of Leslie and Gardner (P. H. Leslie and A. D. Gardner, J. Hyg. 31:423-434, 1931) or phase III in the system of Kasuga et al. (T. Kasuga, Y. Nakase, K. Ukishima, and K. Takatsu, Kitasato Arch. Exp. Med. 26:121-134, 1954).
Bistability and domain wall motion in smectic C phases induced by strong electric fields (1987)

Abstract The director configuration in smectic C phases is bistable in strong electric fields for suitable field directions with respect to the smectic layer planes. Therefore different domains separated by walls are possible. Bistability can be accompanied by director reorientation which causes domain wall motion and pronounced hysteresis effects. Transitions of this type have been investigated both experimentally and theoretically.
Data-parallel abstractions for irregular programs (2008)

Client-side applications running on multicore processors are likely to be irregular programs that deal with complex, pointer-based data structures such as graphs and trees. In her 2007 Turing award lecture, Fran Allen raised an important question about such programs: do irregular programs have data parallelism, and if so, how do we exploit it on multicore processors?
Deconstructing the Pyramid of Prejudice (2014)

On the surface, negative comments by students about race, gender, or sexual preference may seem to be part of the benign banter of youth, but they're exactly where teachers should start their battle — and lessons — to build a better child and world.
Virus-like interference in the latency and prevention of Creutzfeldt–Jakob disease (2003)

We previously showed that intracerebral (ic) inoculation of the attenuated SY strain of Creutzfeld-Jakob disease in mice could delay clinical signs and widespread neuropathology evoked by subsequent ic challenge with the more virulent FU strain. Using lower doses of SY and FU ic, we here demonstrate that mice can be protected well into old age without demonstrable neuropathology or pathologic prion protein (PrP-res). In contrast, parallel FU only controls became terminally diseased 1 year earlier. To determine whether factors elaborated in response to SY might be part of this effect, we evaluated brain and serum samples from additional parallel mice at 90 days after SY infection and just before FU challenge. The infectivity of FU preparations was significantly reduced by mixing with these fresh SY brain homogenates but not by mixing with SY serum samples, suggesting that brain cells were elaborating labile inhibitory factors that were part of the protective response. SY infectivity was too low to be detected in these brain homogenates. Although suppression could be overcome by higher FU doses ic, strong protection against maximal doses of FU was observed by using i.v. inoculations. Because myeloid microglia are infectious and also elaborate many factors in response to the foreign Creutzfeld-Jakob disease agent, it is likely that innate immunity underlies the profound protection shown here. In principle, it should be possible to artificially stimulate relevant myeloid pathways to better prevent and/or delay the clinical and pathological sequelae of these infections.
Support-Intuitionistic Fuzzy Set: A New Concept for Soft Computing (2015)

Today, soft computing is a field that is used a lot in solving real-world problems, such as problems in economics, finance, banking... With the aim to serve for solving the real problem, many new theories and/or tools which were proposed, improved to help soft computing used more efficiently. We can mention some theories as fuzzy sets theory (L. Zadeh, 1965), intuitionistic fuzzy set (K Atanasov, 1986). In this paper, we introduce a new notion of support-intuitionistic fuzzy (SIF) set, which is the combination a intuitionistic fuzzy set with a fuzzy set. So, SIF set is a directly extension of fuzzy set and intuitionistic fuzzy sets (Atanassov). Then, we define some operators on support-intuitionistic fuzzy sets, and investigate some properties of these operators.
An Electrostatic Generating Voltmeter (1933)

An electrostatic generating voltmeter is described which has a strictly linear scale, which has no commutators, and whose calibration is substantially independent of the speed of the driving motor and of the characteristics of the associated vacuum tube amplifier. A means of calibration by use of a wire grid in front of the voltmeter is also described.
Quantitative measurements of indentation moduli by atomic force acoustic microscopy using a dual reference method (2006)

Atomic force acoustic microscopy (AFAM) was used to quantitatively determine material indentation moduli by measuring local mechanical responses. A dual reference method has been shown to be capable of extracting the modulus of a material within 3% of the calculated expected value without any assumptions of the probe’s mechanical properties. The use of this developed method also allows for the calculation of the maximum precision in the quantitative determination of the indentation modulus of materials using AFAM. A parallel analysis of the single and dual reference AFAM techniques isolates the inaccuracy induced by the assumption that the indentation modulus of the atomic force microscopy probe used is the same as bulk silicon.
Soluble Fas ligand in the joints of patients with rheumatoid arthritis and osteoarthritis (1998)

SFL from RA patients expressed FasL, and cleaved sFasL accumulated in the SF of inflamed joints. The different killing activity of membrane-bound FasL and sFasL against synovial cells may regulate Fas-mediated apoptosis in synovial cells.
Transacetalization of Diethyl Tartrate with Acetals of .alpha.-Dicarbonyl Compounds: A Simple Access to a New Class of C2-Symmetric Auxiliaries and Ligands (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTransacetalization of Diethyl Tartrate with Acetals of .alpha.-Dicarbonyl Compounds: A Simple Access to a New Class of C2-Symmetric Auxiliaries and LigandsUlrich Berens, Dieter Leckel, and Susanne C. OepenCite this: J. Org. Chem. 1995, 60, 25, 8204–8208Publication Date (Print):December 1, 1995Publication History Published online1 May 2002Published inissue 1 December 1995https://pubs.acs.org/doi/10.1021/jo00130a019https://doi.org/10.1021/jo00130a019research-articleACS PublicationsRequest reuse permissionsArticle Views957Altmetric-Citations53LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Palmitate-induced cardiac apoptosis is mediated through CPT-1 but not influenced by glucose and insulin (2002)

To test the hypothesis that regulation of palmitate metabolism, through carnitine palmitoyl transferase-1 (CPT-1) or through alterations of glycolysis, was involved in the pathway of palmitate-mediated cell death, cardiomyocytes were cultured from 7-day-old chick embryos. Palmitate-induced cell death, assessed by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay, was enhanced by carnitine, a cofactor needed for palmitate transport into mitochondria via CPT-1. Carnitine co-incubation with palmitate significantly (P < 0.01) increased the amount of apoptotic cells, assessed by propidium iodine staining and fluorescent-activated cell sorting analysis compared with treatment with either palmitate or carnitine alone. The CPT-1 inhibitor oxfenicine significantly (P < 0.05) blocked the cell death induced by the combination of palmitate and carnitine. The short-chain saturated fatty acid capric acid (100 microM), which is not likely transported by CPT-1, did not significantly affect cell viability, whereas the C18 saturated fatty acid stearic (100 microM) significantly (P < 0.01) reduced cell viability and to a similar extent as palmitate. In contrast, there was no significant alteration of palmitate-induced cell death by cotreatment with 100 nM insulin + 2 g/l glucose or 1 mM lactate, which promote ATP generation by glycolysis rather than fatty acid oxidation. Fumonisin did not alter palmitate-induced cell death or apoptosis, suggesting that the effect of palmitate was not operative through increased ceramide synthesis. These results suggest that oxidation of palmitate through CPT-1 is involved in the production of apoptosis in cardiomyocytes.
P‐60: OLED Failure Analysis and Pinpoint Shot Repair of Fault using an Optical Coaxial System of High Sensitive CCD and a Laser (2006)

Abstract A new concept of defect isolation and pinpoint laser repair to the isolated defect in OLED devices has been studied. High sensitive CCD has been combined with laser system (YAG: 532nm) on coaxial optics. An OLED has been submitted for defect isolation and laser repairing. The detected tiny size fault of some μm has been repaired by laser precision shot. As the result of this study, it is cleared that this method has effective to recover the OLED device function as I‐V characteristic and to improve OLED reliability lifetime.
Optimal Huygens’ Metasurface for Wireless Power Transfer Efficiency Improvement (2020)

In this paper, we investigate the electromagnetic response of a Huygens' metasurface (HMS) embedded between the transmitter and receiver coils of a near field wireless power transfer (WPT) system and their interactions for the feasibility of increasing efficiency. To analyze the proposed configuration, we use the point-dipole approximation to describe the electromagnetic fields and boundary conditions governing HMS to calculate the mutual inductance between the coils and to obtain closed-form analytical expressions. The proposed theory shows that by optimally designing the HMS inclusions, the amplitude of the mutual inductance between the transmitter and receiver coils in the near-field WPT can be increased, resulting in improved efficiency. Finally, by drawing on the proposed theory, we design a thin layer and finite-size HMS consisting of 64 elements. The bianisotropic Omega-type particle is used to design the HMS to improve the efficiency of the sample WPT system at the frequency of 100 MHz. The results of the full-wave simulation show that the power transfer efficiency in the free space increases from 25% to 42% in the presence of the proposed HMS.
Electro-Optical Properties of Polymer/(Liquid Crystal) Composite Film Fabricated by Two-step Phase Separation Method (1995)

Abstract A polymer/liquid crystal (LC) composite film was fabricated by a combination of a solvent-induced phase separation method and a photo-polymerization-induced one, using polymethylmethacrylate (PMMA), LC and photo-curable monomers. Electro-optical properties for the composite films had a low driving voltage of 18 Vrms, a rapid turn-on time of 0.8 ms, a rapid turn-off time of 10 ms and a small hysteresis of less than 1Vrms.