gebhart/patrepeval huggingface dataset:
The Port of Mars: The United States and the International Community (2003)

The United States is at a critical crossroads in its foreign policy and its relationship to the international community. Indeed, the very existence of an international community, rooted in the authority of the United Nations and capable of enforcing its resolutions, is from Washington's contemporary perspective an issue of contention. The foreign policy of the administration of George W. Bush has demonstrated, both before and after the tragic events of 11 September 2001, a willingness to undertake major initiatives unilaterally when these are deemed to be in the vital interest of the United States specifically or of international order generally. In light of the inability of the United Nations to exercise collective will in the effort to disarm the aggressive regime of Saddam Hussein in Iraq, 1991-2003, Washington's determination to act alone or in coalitions-of-the-willing to secure international order is a welcome alternative to the international community as it is presently constituted.
Dietary regulation of serine proteinases that are resistant to serine proteinase inhibitors (1997)

Ingestion of Kunitz soybean trypsin inhibitor (STI) by larval Helicoverpa zea, Agrotis ipsilon, and Trichoplusia ni extended the retention time of food in the digestive tract and increased the level of activity of proteolytic enzymes that were not susceptible to inhibition by STI. The level of enhancement of activity of STI-resistant (STI-R) enzyme(s) was directly influenced by the dosage and timing of exposure to STI. However, not all proteinase inhibitors (PIs) enhanced the level of proteinase inhibitor resistant (PI-R) enzymes, even if those PIs inhibited a significant proportion of enzyme activity. These findings suggest that a complex system may be responsible for the regulation of proteolytic enzymes in the midgut of larval Lepidoptera, and one hypothesis for this regulation is proposed.
Nanotechnology-Based Detection and Targeted Therapy in Cancer: Nano-Bio Paradigms and Applications (2011)

The application of nanotechnology to biomedicine, particularly in cancer diagnosis and treatment, promises to have a profound impact on healthcare. The exploitation of the unique properties of nano-sized particles for cancer therapeutics is most popularly known as nanomedicine. The goals of this review are to discuss the current state of nanomedicine in the field of cancer detection and the subsequent application of nanotechnology to treatment. Current cancer detection methods rely on the patient contacting their provider when they feel ill, or relying on non-specific screening methods, which unfortunately often result in cancers being detected only after it is too late for effective treatment. Cancer treatment paradigms mainly rely on whole body treatment with chemotherapy agents, exposing the patient to medications that non-specifically kill rapidly dividing cells, leading to debilitating side effects. In addition, the use of toxic organic solvents/excipients can hamper the further effectiveness of the anticancer drug. Nanomedicine has the potential to increase the specificity of treatment of cancer cells while leaving healthy cells intact through the use of novel nanoparticles. This review discusses the use of nanoparticles such as quantum dots, nanoshells, nanocrystals, nanocells, and dendrimers for the detection and treatment of cancer. Future directions and perspectives of this cutting-edge technology are also discussed.
Pyridine- and Phosphonate-Containing Ligands for Stable Ln Complexation. Extremely Fast Water Exchange on the Gd<sup>III</sup> Chelates (2006)

Two novel ligands containing pyridine units and phosphonate pendant arms, with ethane-1,2-diamine (L2) or cyclohexane-1,2-diamine (L3) backbones, have been synthesized for Ln complexation. The hydration numbers obtained from luminescence lifetime measurements in aqueous solutions of the Eu(III) and Tb(III) complexes are q = 0.6 (EuL2), 0.7 (TbL2), 0.8 (EuL3), and 0.4 (TbL3). To further assess the hydration equilibrium, we have performed a variable-temperature and -pressure UV-vis spectrophotometric study on the Eu(III) complexes. The reaction enthalpy, entropy, and volume for the hydration equilibrium EuL <--> EuL(H2O) were calculated to be DeltaH degrees = -(11.6 +/- 2) kJ mol(-1), DeltaS degrees = -(34.2 +/- 5) J mol(-1) K(-1), and = 1.8 +/- 0.3 for EuL2 and DeltaH degrees = -(13.5 +/- 1) kJ mol(-1), DeltaS degrees = -(41 +/- 4) J mol(-1) K(-1), and = 1.7 +/- 0.3 for EuL3, respectively. We have carried out variable-temperature 17O NMR and nuclear magnetic relaxation dispersion (NMRD) measurements on the GdL2(H2O)q and GdL3(H2O)q systems. Given the presence of phosphonate groups in the ligand backbone, a second-sphere relaxation mechanism has been included for the analysis of the longitudinal (17)O and (1)H NMR relaxation rates. The water exchange rate on GdL2(H2O)q, = (7.0 +/- 0.8) x 10(8) s(-1), is extremely high and comparable to that on the Gd(III) aqua ion, while it is slightly reduced for GdL3(H2O)q, = (1.5 +/- 0.1) x 10(8) s(-1). This fast exchange can be rationalized in terms of a very flexible inner coordination sphere, which is slightly rigidified for L3 by the introduction of the cyclohexyl group on the amine backbone. The water exchange proceeds via a dissociative interchange mechanism, evidenced by the positive activation volumes obtained from variable-pressure 17O NMR for both GdL2(H2O)q and GdL3(H2O)q (DeltaV = +8.3 +/- 1.0 and 8.7 +/- 1.0 cm(3) mol(-1), respectively).
Disease quantification in dermatology:<i>in vivo</i>near-infrared spectroscopy measures correlate strongly with the clinical assessment of psoriasis severity (2013)

Accurate documentation of disease severity is a prerequisite for clinical research and the practice of evidence-based medicine. The quantification of skin diseases such as psoriasis currently relies heavily on clinical scores. Although these clinical scoring methods are well established and very useful in quantifying disease severity, they require an extensive clinical experience and carry a risk of subjectivity. We explore the opportunity to use in vivo near-infrared (NIR) spectra as an objective and noninvasive method for local disease severity assessment in 31 psoriasis patients in whom selected plaques were scored clinically. A partial least squares (PLS) regression model was used to analyze and predict the severity scores on the NIR spectra of psoriatic and uninvolved skin. The correlation between predicted and clinically assigned scores was R=0.94 (RMSE=0.96), suggesting that in vivo NIR provides accurate clinical quantification of psoriatic plaques. Hence, NIR may be a practical solution to clinical severity assessment of psoriasis, providing a continuous, linear, numerical value of severity.
The performance of runtime data cache prefetching in a dynamic optimization system (2003)

Traditional software controlled data cache prefetching is often ineffective due to the lack of runtime cache miss and miss address information. To overcome this limitation, we implement runtime data cache prefetching in the dynamic optimization system ADORE (ADaptive Object code Reoptimization). Its performance has been compared with static software prefetching on the SPEC2000 benchmark suite. Runtime cache prefetching shows better performance. On an Itanium 2 based Linux workstation, it can increase performance by more than 20% over static prefetching on some benchmarks. For benchmarks that do not benefit from prefetching, the runtime optimization system adds only 1%-2% overhead. We have also collected cache miss profiles to guide static data cache prefetching in the ORC compiler. With that information the compiler can effectively avoid generating prefetches for loops that hit well in the data cache.
P‐179: Low Blur Effect and High Light Extraction Efficiency Enhancement of Organic Light Emitting Displays with Novel Microstructure Attachment (2007)

Abstract Microstructure film attachment and surface roughing techniques had long been utilized to improve the light extraction efficiency from a light source with a high refractive index. Instead of merely concerning the efficiency for lighting purposes, we must take both the light extraction efficiency and image quality into account for display applications. The image blur was observed to decrease the contrast ratio and thus lower image quality. In our previous work, we have studied the image blur effect quantitatively and correlated it to the coverage ratio and light extraction efficiency. In this paper, we apply an innovative microstructure array arrangement to planar light emitting device, i.e., for organic light emitting display (OLED) to reduce the blur effect and keep almost the same efficiency as that obtained by applying a traditional microstructure array.
The APx accelerator (2003)

The architectural and implementational features that work together in the APx accelerator to achieve high sustained system performance for a significant set of compute-intensive functions are presented. The features include VLSI integration, memory bandwidth, concurrency of operations, interprocessor communications, processor selection mechanisms, and I/O bandwidth. The APx is an expandable system and provides from 64 to 256 16-bit processors which provide peak instruction rates from 800 to 3200 MIPs. The individual processors in the APx accelerator are 16-bit RISC processors which are quite powerful and versatile. In addition, pairs of 16-bit processors can be configured to operate in 32-bit mode under software control. IEEE format single precision floating-point operations are supported in 32-bit mode with peak ratings from 40 to 160 MFLOPS.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Darmstoff analogs. 3. Actions of choline esters of acetal phosphatidic acids on visceral smooth muscle (1989)

A number of naturally occurring phospholipids, e.g. the acetal phosphatidic acid derivatives that comprise Darmstoff (1) and the phosphatidylcholine derivative platelet activating factor (PAF), cause contraction of certain visceral smooth muscles and cause platelet activation. Because the Darmstoff phosphatidic acids and PAF are structurally similar, it was of interest to compare the biological actions of choline esters of Darmstoff with those of PAF and of the parent Darmstoff phosphatidic acids. To this end, [(2-pentadecyl-1,3-dioxolan-4-yl)methyl]phosphocholine (3a), [[2-(cis-8-heptadecenyl)-1,3-dioxolan-4-yl]methyl]phosphocho line (3b), and [[2-(cis-8-pentadecenyl)-1,3-dioxolan-4-yl]methyl]phosphocho line (3c) were synthesized. Compounds 3a, 3b, 3c, and PAF caused dose-dependent relaxation of taenia coli strips. In contrast, the unesterified materials 1a and 1b, as well as lyso-PAF, caused contraction in taenia coli strips. Thus, the contractile effect of Darmstoff is reversed on esterification with choline. In preparations of whole trachea, both 1a and 3a had contractile effects similar to those of PAF.
Does Prohibitin Expression Regulate Sperm Mitochondrial Membrane Potential, Sperm Motility, and Male Fertility? (2012)

Prohibitin (PHB) is a highly conserved major sperm mitochondrial membrane protein whose absence in somatic cells is associated with mitochondrial membrane depolarization and increased generation of reactive oxygen species (ROS). Our recent findings suggest that high levels of oxidants in human semen may contribute to male infertility and that sperm motility could be the earliest and most sensitive indicator of oxidative damage. Based on PHB's roles in mitochondrial sub-compartmentalization and respiratory chain assembly, we examine sperm PHB expression and mitochondrial membrane potential (MITO) in infertile men with poor sperm motility (asthenospermia, A) and/or low sperm concentrations (oligoasthenospermia, OA). Here, we demonstrate that MITO is significantly lower in sperm from A and OA subjects than in normospermic (N) subjects; the decrease is more severe for OA than for A subjects. PHB expression is also significantly lower in sperm from A and OA subjects. Significantly positive correlations are found among PHB expression, MITO, and sperm motility in normospermic, asthenospermic, and oligoasthenospermic subjects. Collectively, our observations lead to the hypothesis that PHB expression is an indicator of sperm quality in infertile men, and that it regulates sperm motility via an alteration in MITO and increased ROS levels.
A Family of Air Traffic Control Radars (1979)

Some 20 years of activity in the field of air traffic control (ATC) radars is described. This activity includes the production of over 100 equipments installed in 20 countries all over the world and is a relevant technical contribution to provision of reliable surveillance of scheduled air carriers and general aviation. Three generations of equipment have been produced in this series: conventional design, solid state, and adaptive. The technical experience gained in evaluating the performance of ATC radars installed throughout the world is described in terms of target visibility in the clear, a ground clutter, and in adverse metrorological conditions. The estimation of radar coverage in the clear is derived from direct measurement of receiver sensitivity in terms of Pd and Pfa, while flight tests are utilized to verify actual performance in a given operational environment. A criterion to determine the significance of a flight test is described. In the effort to establish a reliable method of measurement, the subclutter visibility over ground clutter is related to the linear dynamic range of the moving-target indicator (MTI) receiver and to the improvement factor. The results obtained for the ATCR-22 adaptive radar line are described. Block diagrams and descriptions of the third generation radar equipment are given.
Turbo-alternator stalling protection using available-power estimate (2011)

In environments where electromechanical loads may suffer from disturbances with large magnitude-such as in sampling downhole reservoirs-stalling protection for the power source of the alternator may be critical to prevent potentially catastrophic system failure. First, a real-time estimation method is described to determine the maximum available electrical power produced by a turbo-alternator for a given volumetric flow rate acting on the turbine. Next, the available-power estimate and used electrical power measurement are used to prevent turbine stalling by regulating an electromechanical load-in this case a permanent magnet synchronous motor (PMSM)-to draw less power. The stalling protection is implemented through an additional proportional-integral-derivative (PID) controller for load power, which is cascaded outside already cascaded velocity and torque PID controllers used for control of the PMSM. To ensure fast tracking, the power PID controller implements integral anti-windup. An experimental evaluation of the methodology is presented.
A Sonochemical Approach to the Synthesis of Crystalline Selenium Nanowires in Solutions and on Solid Supports (2002)

Single crystalline selenium nanowires have been successfully synthesized using a sonochemical process. These uniform nanowires can be grown in solutions or on substrates at room temperature with yields approaching 100 %. The nanowires could also be directed to grow into self-connecting networks (see Figure), and to form electrically continuous connections between two electrodes.
A 5-32 bit decoder for application in a crossbar switch (1993)

A novel voltage state multiple input NOR gate has been designed and tested for use as the basic gate in a 5-32 b parallel-input decoder. Two versions of this NOR gate are presented, one with a single output and one with a selectable output. The combination of the two types of NOR gate makes it possible to construct a 5-32 b decoder with considerably less gate current than would be required if it were constructed in other logic families. Since only a single gate current is required by each NOR gate and because only 12 NOR gates are needed to build the full decoder, a clock with a peak current level of only 6 mA is sufficient to power all of the decoder's 72 constituent superconducting quantum interference devices (SQUIDs). The decoder also occupies a small area compared with other designs. The authors review critical design issues of the NOR gates, and present low-speed and high-speed results of subblocks of the full 5-32 b decoder.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Electrochemical detection of p-ethylguaiacol, a fungi infected fruit volatile using metal oxide nanoparticles (2014)

Nanoparticles of TiO(2) or SnO(2) on screen-printed carbon (SP) electrodes have been developed for evaluating their potential application in the electrochemical sensing of volatiles in fruits and plants. These metal oxide nanoparticle-modified electrodes possess high sensitivity and low detection limit for the detection of p-ethylguaiacol, a fingerprint compound present in the volatile signature of fruits and plants infected with a pathogenic fungus Phytophthora cactorum. The electroanalytical data obtained using cyclic voltammetry and differential pulse voltammetry showed that both SnO(2) and TiO(2) exhibited high sensitivity (174-188 μA cm(-2) mM(-1)) and low detection limits (35-62 nM) for p-ethylguaiacol detection. The amperometric detection was highly repeatable with RSD values ranging from 2.48 to 4.85%. The interference studies show that other common plant volatiles do not interfere in the amperometric detection signal of p-ethylguaiacol. The results demonstrate that metal oxides are a reasonable alternative to expensive electrode materials such as gold or platinum for amperometric sensor applications.
Metformin Decreases the Dose of Chemotherapy for Prolonging Tumor Remission in Mouse Xenografts Involving Multiple Cancer Cell Types (2011)

Metformin, the first-line drug for treating diabetes, selectively kills the chemotherapy resistant subpopulation of cancer stem cells (CSC) in genetically distinct types of breast cancer cell lines. In mouse xenografts, injection of metformin and the chemotherapeutic drug doxorubicin near the tumor is more effective than either drug alone in blocking tumor growth and preventing relapse. Here, we show that metformin is equally effective when given orally together with paclitaxel, carboplatin, and doxorubicin, indicating that metformin works together with a variety of standard chemotherapeutic agents. In addition, metformin has comparable effects on tumor regression and preventing relapse when combined with a four-fold reduced dose of doxorubicin that is not effective as a monotherapy. Finally, the combination of metformin and doxorubicin prevents relapse in xenografts generated with prostate and lung cancer cell lines. These observations provide further evidence for the CSC hypothesis for cancer relapse, an experimental rationale for using metformin as part of combinatorial therapy in a variety of clinical settings, and for reducing the chemotherapy dose in cancer patients.
Visual Bilingual Lexicon Induction with Transferred ConvNet Features (2015)

This paper is concerned with the task of bilingual lexicon induction using imagebased features. By applying features from a convolutional neural network (CNN), we obtain state-of-the-art performance on a standard dataset, obtaining a 79% relative improvement over previous work which uses bags of visual words based on SIFT features. The CNN image-based approach is also compared with state-of-the-art linguistic approaches to bilingual lexicon induction, even outperforming these for one of three language pairs on another standard dataset. Furthermore, we shed new light on the type of visual similarity metric to use for genuine similarity versus relatedness tasks, and experiment with using multiple layers from the same network in an attempt to improve performance.
Monolithic 3D-ICs with single crystal silicon layers (2012)

Approaches to obtain monolithic 3D logic and memory ICs are proposed in this paper. 3-4x higher memory density with similar litho cost can be obtained with monolithic 3D memories, while benefits similar to a generation of scaling can be obtained with monolithic 3D logic by doubling the number of device layers. Well-known, manufacturing-friendly materials, process steps and device structures are used.
A Novel Vitamin D<sub>3</sub>Analog, 22-Oxa-1, 25- Dihydroxyvitamin D<sub>3</sub>, Inhibits the Growth of Human Breast Cancer<i>in Vitro</i>and<i>in Vivo</i>without Causing Hypercalcemia* (1991)

Although 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] has been shown to inhibit the growth of certain malignant cells, its hypercalcemic effect has prevented clinical application. We have recently developed a novel vitamin D3 analog, 22-oxa-1,25-(OH)2D3 (OCT), that is capable of promoting differentiation and inhibiting proliferation without inducing hypercalcemia. The present study was undertaken to determine whether OCT could be applied for the treatment of breast cancer with or without estrogen receptor (ER). OCT inhibited the proliferation of both ER-positive (MCF-7, T-47D, and ZR-75-1) and ER-negative breast cancer cells (MDA-MB-231 and BT-20) in vitro in a time- and dose-dependent manner, as determined by cell number and [3H]thymidine uptake. The antiproliferative effect was observed with a concentration as low as 10(-11) M OCT, and treatment of MCF-7 cells with 10(-8) M OCT for 8 days caused more than a 50% reduction in cell number compared with that of vehicle-treated cells. OCT was approximately 1 order of magnitude more potent than 1,25-(OH)2D3 in inhibiting the proliferation of MCF-7 cells. The in vivo effect of OCT was examined in athymic mice implanted with ER-negative MX-1 tumor, which was established as the xenograft derived from human breast carcinoma. Intratumor administration of OCT three times a week remarkably delayed the growth of MX-1 tumor in a time- and dose-dependent manner. The antitumor effect of 1 microgram/kg BW OCT was greater than that of 500 microgram/kg BW adriamycin, and the relative tumor weights in each group on day 26 were 29.7% and 50.5% of that in the vehicle-treated group, respectively. The effects of OCT and adriamycin were additive, and the relative tumor weight after 26 days of combined treatment was 21.7% of that in the vehicle-treated group. Oral administration of OCT was also effective, and the relative tumor weight in the OCT-treated group (1 microgram/kg BW) was 54.6 +/- 0.1% (mean +/- SEM) of that in the vehicle-treated group. Neither intratumor nor oral administration of OCT raised the serum calcium level in these animals. These results demonstrate that OCT is a potent inhibitor of the proliferation of breast cancer cells with or without ER and that OCT inhibits the growth of breast cancer in vivo without inducing hypercalcemia. We suggest that OCT may provide a new strategy for the treatment of breast carcinoma regardless of ER status.