gebhart/patrepeval huggingface dataset:
Automatic human motion classification from Doppler spectrograms (2010)

A technique, recently introduced for visual pattern classification, is successfully applied for classification of human gait based on radar Doppler signatures depicted in the time-frequency domain. It is shown that the proposed classification technique implements steps that, in essence, act on revealing the distinctive Doppler features of the human walking and, as such, allows effective discrimination of various types of human motions characterized by the nature of arm swings. We specifically consider three types of arm motions, namely, free swings, one-arm confined swings, and no-arm swings. The last two arm motions can be indicative of a human carrying objects or a person in stressed situations. The paper explains the different processing stages of motion classification architecture and demonstrates their contributions to the final decision.
Channelrhodopsin2 Current During the Action Potential: “Optical AP Clamp” and Approximation (2014)

The most widely used optogenetic tool, Channelrhodopsin2 (ChR2), is both light- and voltage-sensitive. A light-triggered action potential or light-driven perturbations of ongoing electrical activity provide instant voltage feedback, shaping ChR2 current. Therefore, depending on the cell type and the light pulse duration, the typically reported voltage-clamp-measured ChR2 current traces are often not a good surrogate for the ChR2 current during optically-triggered action potentials. We discuss two experimental methods to reveal ChR2 current during an action potential: an "optical AP clamp" and its approximation employing measured current-voltage curve for ChR2. The methods are applicable to voltage- and light-sensitive ion currents operating in excitable cells, e.g. cardiomyocytes or neurons.
MICRODEVICE FOR CELL AND PARTICLE SEPARATION USING DIELECTROPHORETIC FIELD-FLOW FRACTIONATION (2000)

We describe the use of a micro system for dielectrophoretic field flow fractionation (DFFF) of particles and cells. Micro-objects are separated on the basis of differences in size and/or passive dielectric properties, respectively. Bow-like strip electrode pairs have been proven to be the most effective separation systems.
Peptide–LNA oligonucleotide conjugates (2013)

Although peptide-oligonucleotide conjugates (POCs) are well-known for nucleic acids delivery and therapy, reports on internal attachment of peptides to oligonucleotides are limited in number. To develop a convenient route for preparation of internally labeled POCs with improved biomedical properties, peptides were introduced into oligonucleotides via a 2'-alkyne-2'-amino-LNA scaffold. Derivatives of methionine- and leucine-enkephalins were chosen as model peptides of mixed amino acid content, which were singly and doubly incorporated into LNA/DNA strands using highly efficient copper(i)-catalyzed azide-alkyne cycloaddition (CuAAC) "click" chemistry. DNA/RNA target binding affinity and selectivity of the resulting POCs were improved in comparison to LNA/DNA mixmers and unmodified DNA controls. This clearly demonstrates that internal attachment of peptides to oligonucleotides can significantly improve biomolecular recognition by synthetic nucleic acid analogues. Circular dichroism (CD) measurements showed no distortion of the duplex structure by the incorporated peptide chains while studies in human serum indicated superior stability of the POCs compared to LNA/DNA mixmers and unmodified DNA references. Molecular modeling suggests strong interactions between positively charged regions of the peptides and the negative oligonucleotide backbones which leads to clamping of the peptides in a fixed orientation along the duplexes.
Xylitol production by<i>Cyberlindnera</i>(<i>Williopsis) saturnus</i>, a tropical mangrove yeast from xylose and corn cob hydrolysate (2013)

Microbes offer an economically viable and green approach for production of xylitol, an industrially important compound. A mangrove ecosystem with its battery of lignocellulolytic enzymes is an ideal location for isolating fungi capable of producing xylitol from agroindustrial waste such as CCH.
Frontiers in bioprocessing (1989)

Problems and Challenges in the Production and Processing of Biologically Active Materials. PROCESS INTEGRATION. Development of a Reverse-Phase HPLC Process Step for Recombinant b-Interferon. Sensitivity Analysis of an Integrated Process of Lignocellulose Conversion to Ethanol. The Story of Biosynthetic Human Insulin. Purification and Sequencing of Interferons and Other Biologically Active Proteins and Polypeptides. ADVANCES IN FERMENTATION. Kinetics of Immobilized Cells: A Structured Model. Bioreactors and Models for Genetically Modified Organisms. Mammalian Cell Culture: An Overview of the Problems and Various Approaches for the Development of Large-Scale Systems. Use of Fungal Elicitors to Increase the Yield of Secondary Products in Plant Cell Cultures. Using a Structured Kinetic Model for Analyzing Instability in Recombinant Bacterial Cultures. Preliminary Analysis of a Hollow Fiber Extractive Fermentor for the Production of Ethanol. Simulation Results of Applying a Robust Multivariable Control Design Methodology to a Generalized Bacterial Growth System. RepA mRNA, a Potential Rate-Limiting Factor in Replication of R1 Plasmids. Bacillus subtilis as a Host of Recombinant Vectors: The Protease Problem. BIOSENSORS. Integrated Biosensors. Sensing Techniques for Bioprocess Monitoring and Control. Mass Fabricated Ion, Gas, and Enzyme Multispecies Sensors Using Integrated Circuit Technology. Flux Determination in Cellular Bioreaction Networks: Applications to Lysine Fermentations. BIOSEPARATIONS I: FREE FLUID METHODS. Analytical Cell Electrophoresis as a Tool in Preparative Cell Electrophoresis. Effective Principles for Scaleup of Electrophoresis. Electrophoresis Experiments in Space. Cell Partitioning in Two-Polymer-Phase Systems: Towards Higher Resolution Separations. Large-Scale Affinity Partitioning of Enzymes in Aqueous Two-Phase Systems. Computerized Strategy for Estimation of Protein Purity. BIOSEPARATIONS II: CHROMATOGRAPHIC METHODS. Purification of Proteins of Low Value in High Volume. High Performance Adsorption Separations. Preparative-Scale Chromatographic Processes: Ion-Exchange and Affinity Chromatographic Separations. Adsorption Chromatography: Approaches to Computer-Based Optimization and Modeling of Column Processes. Immobilized Metal Ion Affinity Chromatography of Transferrins. HPLC Scale Up for Uracil-DNA Glycosylase Purification. BIOSEP: A Novel Approach to Precompetitive Research in Downstream Processing. EMERGING TECHNOLOGIES IN BIOPROCESSING. Large-Scale Fluidized-Bed Bioreactor Systems. Multiphase Membrane Reactors for Enzymatic Resolution: Diffusional Effects on Stereoselectivity. Protein Engineering for the Development of Novel Affinity Separations. Microbial Metal Leaching and Resource Recovery Processes. Coal Biosolubilization.
Oral delivery of tumor‐targeting <i>Salmonella</i> for cancer therapy in murine tumor models (2007)

Tumor-targeting bacteria have been investigated intensively in recent years as anticancer agents. To ensure the reliability of infection, bacteria have conventionally been injected intravenously or intraperitoneally into animals or humans. However, systemic infection of bacteria is rather inconvenient and carries the risk of obvious toxicity. Here we tested whether Salmonella typhimurium VNP20009, a tumor-targeting strain, could be administrated orally for tumor therapy. Tumor-targeting potential, antitumor effects, as well as toxicity of orally administrated VNP20009 were investigated in this study. Oral delivery of VNP20009 not only exhibited high tumor-targeting potential, but also led to a significant anticancer effect by delaying tumor growth and prolonging survival in murine tumor models. As part of combination therapy, orally administrated bacteria notably improved the antitumor effect of cyclophosphamide. In vitro and in vivo studies showed that VNP20009 significantly induced tumor cell apoptosis. No obvious toxicity was observed during the treatments with oral inoculation of VNP20009. Comparative analysis of toxicity in tumor-bearing and tumor-free mice further revealed that orally administrated Salmonella had high safety compared to conventional systemic infection of bacteria. The findings indicated that oral administration of tumor-targeting bacteria is effective and safe. This approach provides a novel avenue in the application of bacteria as a potential antitumor agent.
Nicaragua - Offgrid Rural Electrification Project : Indigenous Peoples Plan (2003)

Expansion of electric power to indigenous populations within the municipalities of Puerto Cabezas, and Waspam in Nicaragua, constitutes a crucial factor under the Offgrid Rural Electrification Project, for the dynamics of communal economies, and to articulate their productivity. However, despite the project's provision of basic services to communities, its multi-dimensional implication among communities, requires an organization, and implementation in compliance not only with the country's legal framework, but with indigenous people's traditional practices, and culture. This Indigenous Peoples Plan (IPP) looks at participatory methods to exercise the process of electrification, so as to improve the living conditions of both indigenous and ethnic populations in the project areas. Based on surveys, and in consultation with local communities, the participatory approach taken conveys the following actions to be taken: 1) establishment of a municipal system to disseminate program information, to be articulated through community networks that would ensure project implementation; 2) fostering territorial encounters to enhance local activities; 3) establishment of food security mechanisms at the municipal level, to mitigate the devastating impacts of natural disasters; 4) implementation of childhood educational systems to raise educational levels, and, establishment of rehabilitation centers for youth groups at risk of delinquency, to include as well institutional coordination for the prevention of drug uses; 5) youth integration to an active economy, through micro-enterprise development programs; and, 6) promotion of women in the management of community enterprises.
Reduced Inorganic Carbon Transport in a CO<sub>2</sub>-Requiring Mutant of <i>Chlamydomonas reinhardii</i> (1983)

A mendelian mutant of the unicellular green alga Chlamydomonas reinhardii has been isolated that is deficient in inorganic carbon transport. This mutant strain, designated pmp-1-16-5K (gene locus pmp-1), was selected on the basis of a requirement of elevated CO(2) concentration for photoautrophic growth. Inorganic carbon accumulation in the mutant was considerably reduced in comparison to wild type, and the CO(2) response of photosynthesis indicated a reduced affinity for CO(2) in the mutant. At air levels of CO(2) (0.03-0.04%), O(2) inhibited photosynthesis and stimulated the synthesis of photorespiratory intermediates in the mutant but not in wild type. Neither strain was significantly affected by O(2) at saturating CO(2) concentration. Thus, the primary consequence of inorganic carbon transport deficiency in the mutant was a much lower internal CO(2) concentration compared to wild type. From these observations, we conclude that enzyme-mediated transport of inorganic carbon is an essential component of the CO(2) concentrating system in C. reinhardii photosynthesis.
Two-dimensional process simulation using verified phenomenological models (1991)

Two-dimensional (2-D) effects are becoming increasingly important in the diffusion of impurities in submicrometer silicon devices. The authors describe a 2-D process simulator, PREDICT2, that handles implant damage effects, annealing, and lateral diffusion. PREDICT2 simulates the diffusion of impurities in silicon by using phenomenological diffusion coefficients. The phenomenological models are verified by comparing simulated and experimental results. This approach is compared with that of point-defect-based simulators. The experimental technique for measuring impurity profiles in two dimensions is outlined. The method for generating diffusion models is illustrated by examining 2-D phosphorous diffusion. Numerical simulations and experimental measurements are compared. The numerical methods used in the simulator are described, and directions for future work are suggested.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Computed Tomographic Study of the Common Cold (1994)

The common cold is associated with frequent and variable anatomical involvement of the upper airways, including occlusion and abnormalities in the sinus cavities.
The Stylus-shopping from home (2003)

Describes a pen-shaped bar-code reading wand which connects to a telephone. Using the wand, someone can quickly place an order for their groceries out of a bar-code filled catalog and have the groceries delivered. The wand is extremely easy to use and can be leased for $3 per month. People who have difficulty leaving their homes or with speech impairments can use this want to interact with supermarkets, banks, and other organisations. Their self-reliance is increased because they no longer have to depend on others to do their shopping.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
On the spectroscopic measurements used to support the postulate of states with fractional principal quantum numbers in hydrogen (2008)

It is suggested that spectral lines, on which the fiction of fractional principal quantum numbers in the hydrogen atom is based, are nothing else but artefacts.
Spectrophotometric Quantitation of Tissue Culture Cell Number in Any Medium (1996)

We have developed a spectrophotometric assay for cell number in suspensions of tissue culture cells. For each cell type tested, absorbance between 650 and 800 nm is linearly dependent upon cell density over a 50-fold range and is independent of the color or composition of the medium in which cells are suspended. A standard curve of absorbance vs. cell density is used to estimate cell number with accuracy and reproducibility superior to hemacytometer counting and with speed and ease surpassing use of a Coulter counter. Less than 5000 cells are needed for this quantitation. The same cells that are counted can be maintained live in culture after the reading is taken, thus allowing the growth of cells to be measured within individual cultures over time. The assay should be readily extended to assays of cell number directly within microplate culture wells. The spectrophotometric assay described here is of significant use in all experiments requiring rapid, accurate measurements of cell number, including determinations of cell doubling time and equal plating of parallel cultures.
web services customization (2006)

In this paper, we propose a framework for dynamic Web services customization. The basic idea consists to automatically transform Web services configurations, published in services directories, into other ones better suited for client needs. The goal of this automatic transformation, based mainly on dynamic Web services composition, is twofold. On the one hand, it makes it easier for Web services providers to perform services customization. On the other hand, it allows services requesters to obtain a Web service with the configurations that satisfy their preferences, even when those preferences are not explicitly published in Web services directories.
Detecting and Measuring Cotranslational Protein Degradation in Vivo (2000)

Nascent polypeptides emerging from the ribosome and not yet folded may at least transiently present degradation signals similar to those recognized by the ubiquitin system in misfolded proteins. The ubiquitin sandwich technique was used to detect and measure cotranslational protein degradation in living cells. More than 50 percent of nascent protein molecules bearing an amino-terminal degradation signal can be degraded cotranslationally, never reaching their mature size before their destruction by processive proteolysis. Thus, the folding of nascent proteins, including abnormal ones, may be in kinetic competition with pathways that target these proteins for degradation cotranslationally.
大功率砷化镓(GaAs)、碳化硅(SiC)器件在电源中的应用 (2003)

随着半导体工业的发展,现在已经可以生产用砷化镓或碳化硅材料为基片的新型大功率肖特基二极管。这篇论文描述了两个方面的内容,主要是了解这些器件的工作特性。当替换常规器件时应该考虑到它的工作特性不同于双极型硅二极管。其更显突出的动态特性会使寄生现象对工作行为的影响加大,因此要考虑封装和所引起的二次效应。这些效应要参考典型砷化镓、碳化硅二极管的实际工况,随着技术的发展,这些器件将会有更美好的前景。
[Etiologic analysis of 12 cases of silicosis with right middle lobe atelectasis]. (2004)

肺不张在矽肺患者中并不少见,形态学诊断并不难,难点在于病因诊断.如果病因能得到及时、准确的诊断,肺复张的可能性相应增大,反之,肺不能复张.现将我院收集到的12例矽肺并右肺中叶不张的明确病因诊断报道如下。
Effect of Initial Microstructure on the Coarsening Behavior of Cementite Particles. (1999)

The effect of initial microstructures, martensite and bainite, on the coarsening behavior of cementite particles during tempering at 973 K for medium carbon steels has been investigated. The coarsening of cementite particles in bainite proceeded more slowly than in martensite, due to the thermal stability of cementite particles in bainite. The coarsening of cementite particles proceeded by a combination of the different coarsening mechanisms. The observed coarsening kinetics in martensite were found as a combination of boundary diffusion and diffusion along dislocation for cementite particles at boundaries, and a combination of boundary diffusion and matrix diffusion for cementite particles within laths. In bainite, the coarsening was controlled by a combination of boundary diffusion and diffusion along dislocation for intergranular particles, and controlled mainly by diffusion along dislocation for intragranular particles.
Refined Filtering of Image Noise Using Local Statistics (1980)

An effective algorithm for digital image noise filtering is presented in this paper. Mostnoise filtering techniques such as Kalman filter and transform domain methods require extensive image modeling and produce filtered images with considerable contrast loss. The algorithm proposed in this paper is an extension of Lee's local statistics method modified to utilize local gradient information. It does not require image modeling, and it will not smear edges and subtle details. For both the additive and multiplicative noise cases, the local mean and variance are computed from a reduced set of pixels depending on the orientation of the edge. Consequently, noise along the edge is removed, and the sharpness of the edge is enhanced. For practical applications when the noise variance is spatially varying and unknown, an adaptive filtering algorithm is developed. Experiments show its good potential for processing real-life images. Examples on images containing 256×256 pixels are given to substantiate the theoretical development.
Archaeological Survey Annual Report, 1962-1963. Department of Anthropology and Sociology, University of California, Los Angeles, 1963. 517 pp., 21 figs., 28 pls., 9 maps, 36 tables, n.p. (1964)

Archaeological Survey Annual Report, 1962-1963. Department of Anthropology and Sociology, University of California, Los Angeles, 1963. 517 pp., 21 figs., 28 pls., 9 maps, 36 tables, n.p. - Volume 30 Issue 2Part1
A novel modulation strategy for isolated modular multilevel DC/DC converter's sub-module dc voltage oscillation damping (2016)

This paper focuses on the modulation strategy optimization of an isolated modular multilevel DC/DC converter (IMMDC). IMMDC sub-modules' dc capacitor and arm inductor has an inherent resonance condition, which leads to high oscillation in arm current dc component. Traditional two-level or quasi two-level phase shift operation has no damping capability to this resonance. In this paper, a novel modulation strategy and corresponding control strategy are proposed to damp this kind oscillation in IMMDC. The simulation results are provided and a down-scaled prototype has been built as well to verify the proposed modulation and control strategies.
Matrix Metalloproteinase 9 Activity Enhances Host Susceptibility to Pulmonary Infection with Type A and B Strains of <i>Francisella tularensis</i> (2007)

A striking feature of pulmonary infection with the Gram-negative intracellular bacterium Francisella tularensis, a category A biological threat agent, is an intense accumulation of inflammatory cells, particularly neutrophils and macrophages, at sites of bacterial replication. Given the essential role played by host matrix metalloproteinases (MMPs) in modulating leukocyte recruitment and the potentially indiscriminate destructive capacity of these cells, we investigated whether MMP-9, an important member of this protease family released by neutrophils and activated macrophages, plays a role in the pathogenesis of respiratory tularemia. We found that F. tularensis induced expression of MMP-9 in FVB/NJ mice and that the action of this protease is associated with higher bacterial burdens in pulmonary and extrapulmonary tissues, development of more extensive histopathology predominated by neutrophils, and increased morbidity and mortality compared with mice lacking MMP-9 (MMP-9(-/-)). Moreover, MMP-9(-/-) mice were able to resolve infection with either the virulence-attenuated type B (live vaccine strain) or the highly virulent type A (SchuS4) strain of F. tularensis. Disease resolution was accompanied by diminished leukocyte recruitment and reductions in both bacterial burden and proinflammatory cytokine production. Notably, neutrophilic infiltrates were significantly reduced in MMP-9(-/-) mice, owing perhaps to limited release of Pro-Gly-Pro, a potent neutrophil chemotactic tripeptide released from extracellular matrix through the action of MMP-9. Collectively, these results suggest that MMP-9 activity plays a central role in modulating the clinical course and severity of respiratory tularemia and identifies MMPs as novel targets for therapeutic intervention as a means of modulating neutrophil recruitment.
Early HSCT corrects the skeleton in MPS (2015)

In this issue of Blood, Pievani et al have identified a potential solution to the remaining barrier to the success of hematopoietic stem cell transplantation (HSCT) in children with severe phenotype Hurler syndrome (mucopolysaccharidosis type I [MPS I]).
Increased Giα and Goα mRNAs in hippocampus after repeated methamphetamine administration (1996)

Changes in transcription of Gs alpha, Gi2 alpha and Go alpha proteins after repeated methamphetamine administration were investigated using in situ hybridization. Rats received daily injections of methamphetamine (4 mg kg-1) for 14 days. Four hours after the last injection, Go alpha mRNA showed an increase of 16.6-31.6% in CA1, CA3 and dentate gyrus of the hippocampus. Gi alpha mRNA level increased by 24.2% in CA1, while Gs alpha mRNA remained unaffected. Go alpha and Gi alpha mRNA returned to basal levels after 48 h abstinence. The expression of these G alpha mRNA in other brain regions, including substantia nigra, ventral tegmentum area, striatum, accumbens and cortices, was unchanged. The increase in Go alpha and Gi alpha mRNAs restricted only to the hippocampus after repeated methamphetamine administration may be involved in the development of dependence rather than behavioral sensitization.