gebhart/patrepeval huggingface dataset:
2‐Anilinobenzamides as SIRT Inhibitors (2006)

SIRTs, class III histone deacetylases, have been suggested to be associated with certain diseases such as cancer and HIV. Thus, SIRT inhibitors are of interest not only to elucidate the biological functions of the enzyme, but also as potential therapeutic agents. 2-Anilinobenzamide was identified in a nocotinamide- and benzamide-focused compound library as a novel SIRT inhibitor. This compound caused the accumulation of acetylated p53 in HCT116 cells. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2452/2006/z600162_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Bioequivalence: Issues and perspectives (2007)

The design, performance and evaluation of bioavailability and bioequivalence have evolved over the last two decades. Bioequivalence (BE) means the absence of a greater-than-allowable difference between the systemic bioavailability of a test product and that of a reference product. Due to efforts by academia, the pharmaceutical industry and health authorities, there is far-reaching consensus on essential questions of bioequivalence trials which have been reflected in the many regulatory guidelines. Despite the introduction and wide acceptance of stringent requirements for bioequivalence studies, there is, however, increasing awareness that some fundamentals of bioequivalence assessment need to be reconsidered in principal. This includes several debatable issues such as practical strategies for bioequivalence of highly variable drugs, drugs with long half life, drugs under genetic polymorphic metabolism, biopharmaceuticals and endogenous substances; single bioequivalence range for all drugs; inclusion of female volunteers; individual versus average bioequivalence; metrics of absorption; etc. This article is an attempt to highlight current thinking on issues in bioequivalence.
Influence of Steam Treatment and Fumigation of Soil on Growth and Elemental Composition of Avocado Seedlings (1973)

Abstract Steam treatment or fumigation of Greenfield sandy loam and Fallbrook sandy loam with D‐D, chloropicrin, ethylene dibromide, propylene oxide, or carbon disulfide decreased P absorption by Mexicola avocado ( Persea americana ) seedlings subsequently grown in the soils. The P deficiency was corrected by applications of 135 to 540 ppm P to the soils. Fumigation with D‐D, chloropicrin, or ethylene dibromide caused halide injury on the older plant leaves. In general injury was more severe following D‐D or chloropicrin treatment than following ethylene dibromide fumigation. Tests with KCl and KBr, however, indicated that Br ‐ was more toxic than Cl ‐ to the seedlings. Phosphorus additions to the soil accentuated the halide injury and relative growth retardation related to halide excesses. Leaf Mn was increased up to 10 fold by steam treatment or fumigation with D‐D, chloropicrin, or carbon disulfide. Additions of P to the soil enhanced Mn absorption. Leaf Mn although attaining concentrations of > 1,000 ppm did not appear to be directly related to plant growth. The treatments exerted little effect on leaf Ca, Mg, K, Na, Cu, Zn, or Fe concentrations.
PASTA 2.0: an improved server for protein aggregation prediction (2014)

The formation of amyloid aggregates upon protein misfolding is related to several devastating degenerative diseases. The propensities of different protein sequences to aggregate into amyloids, how they are enhanced by pathogenic mutations, the presence of aggregation hot spots stabilizing pathological interactions, the establishing of cross-amyloid interactions between co-aggregating proteins, all rely at the molecular level on the stability of the amyloid cross-beta structure. Our redesigned server, PASTA 2.0, provides a versatile platform where all of these different features can be easily predicted on a genomic scale given input sequences. The server provides other pieces of information, such as intrinsic disorder and secondary structure predictions, that complement the aggregation data. The PASTA 2.0 energy function evaluates the stability of putative cross-beta pairings between different sequence stretches. It was re-derived on a larger dataset of globular protein domains. The resulting algorithm was benchmarked on comprehensive peptide and protein test sets, leading to improved, state-of-the-art results with more amyloid forming regions correctly detected at high specificity. The PASTA 2.0 server can be accessed at http://protein.bio.unipd.it/pasta2/.
Gene delivery: intelligent but just at the beginning (2004)

Gene therapy is used to treat genetic disorders, which may be achieved both ex vivo and in vivo. Gene-delivery systems usually include a carrier system which both protects the gene expression plasmid and allows its extracellular and intracellular trafficking. Viruses are used in most of the clinical trials today; however, they do have important drawbacks. Non-viral vectors based on lipids, water-soluble polycations, other non-condensing polymers and nano- or microparticles/capsules have been proposed. Cationic polymers, especially carrying novel targeting ligands. are receiving increasing attention. Intelligent polymers with temperature, pH, and light sensitivities for a controllable and effective non-viral transfection have recently been introduced but are just at the beginning. Our preliminary studies showed that block copolymers of N-isopropylacrylamide-acrylic acid with poly(ethylene imine) could be one example of these novel non-viral vectors.
A high voltage, constant current stimulator for electrocutaneous stimulation through small electrodes (1999)

A high-voltage stimulator has been designed to allow transcutaneous stimulation of tactile fibers of the fingertip. The stimulator's output stage was based upon an improved Howland current pump topology, modified to allow high load impedances and small currents. The compliance voltage of approximately 800 V is achieved using commercially available high-voltage operational amplifiers. The output current accuracy is better than +/- 5% over the range of 1 to 25 mA for 30 microseconds or longer pulses. The rise time for square pulses is less than 1 microsecond. High-voltage, common-mode, latch-up power supply problems and solutions are discussed. The stimulator's input stage is optically coupled to the controlling computer and complies with applicable safety standards for use in a hospital environment. The design presented here is for monophasic stimulation only, but could be modified for biphasic stimulation.
Suppressor T cell activation by human leukocyte interferon. (1983)

Murine fibroblast interferon (IFN beta) activates murine suppressor T lymphocytes in vitro, which suppress plaque-forming cell responses by spleen cells. Suppression of human in vitro immune responses by IFN was investigated to determine whether human IFN also activates suppressor T cells. Human leukocyte IFN (IFN alpha) suppressed pokeweed mitogen-induced polyclonal immunoglobulin production by human peripheral blood mononuclear cells (PBMC) by 80 to 90% at doses of 200 to 350 U/ml. Responses by IFN alpha-treated PBMC were suppressed in a dose-dependent manner; control cultures had maximal responses on day 7. PBMC incubated with 10,000 U/ml of IFN alpha contained activated suppressor cells that decreased pokeweed mitogen-stimulated, polyclonal immunoglobulin production by autologous cells by 70 to 80%. Suppression mediated by these cells was prevented by catalase, ascorbic acid, and 2-mercaptoethanol (2-ME). In murine systems, these reagents interfere with expression of suppressor T cell activity by preventing activation of soluble immune response suppressor. Selection procedures with monoclonal antibodies identified the suppressor cell as an OKT8+ (suppressor/cytotoxic) T lymphocyte. Selected OKT8+ cells required less IFN alpha (1000 U/ml) for activation and were effective in smaller numbers than unfractionated activated PBMC. IFN alpha-activated suppressor cells also inhibited proliferation in mixed lymphocyte and mitogen-stimulated PBMC cultures; again, catalase and 2-ME blocked suppression. These results indicate that IFN alpha activates suppressor T cells in human PBMC cultures; the ability of catalase, 2-ME, and ascorbic acid to block suppression suggests that these suppressor T cells have certain similarities to IFN beta or to concanavalin A-activated murine suppressor T cells.
An efficient design method of microwave oscillator circuits for minimum phase noise (1999)

In this paper, we describe a newly developed design method of high-Q microwave oscillator circuits leading to the minimum phase noise for a given transistor and resonator. The key point of the method is the maximization of the energy stored in the resonator and its transfer to the controlling input voltage port of the transistor. The proposed method has been applied to two experimental oscillators setups with pseudomorphic high electron-mobility transistors (PHEMTs). A state of-the art phase noise of -50 dBc at 10-Hz offset from carrier with a 1/f/sup 3/ slope has been measured at room temperature with a 9.2 GHz oscillator. The efficiency of this design method and its ease of use represent, in our opinion, a real breakthrough in the field of low noise transistor oscillator circuit design.
Involvement of Neuropeptide Y in Post-Incisional Nociception in Rats (2018)

NPY is extensively expressed in the superficial laminae of the spinal cord and exhibit marked changes after incision. Nociception is also decreased after its administration. Hence, it is likely involved in post-incisional nociception. This information could have clinical relevance.
Adaptive Workload Prediction of Grid Performance in Confidence Windows (2009)

Predicting grid performance is a complex task because heterogeneous resource nodes are involved in a distributed environment. Long execution workload on a grid is even harder to predict due to heavy load fluctuations. In this paper, we use Kalman filter to minimize the prediction errors. We apply Savitzky-Golay filter to train a sequence of confidence windows. The purpose is to smooth the prediction process from being disturbed by load fluctuations. We present a new adaptive hybrid method (AHModel) for load prediction guided by trained confidence windows. We test the effectiveness of this new prediction scheme with real-life workload traces on the AuverGrid and Grid5000 in France. Both theoretical and experimental results are reported in this paper. As the lookahead span increases from 10 to 50 steps (5 minutes per step), the AHModel predicts the grid workload with a mean-square error (MSE) of 0.04-0.73 percent, compared with 2.54-30.2 percent in using the static point value autoregression (AR) prediction method. The significant gain in prediction accuracy makes the new model very attractive to predict Grid performance. The model was proved especially effective to predict large workload that demands very long execution time, such as exceeding 4 hours on the Grid5000 over 5,000 processors. With minor changes of some system parameters, the AHModel can apply to other computational grids as well. At the end, we discuss extended research issues and tool development for Grid performance prediction.
Diagnosis of human cytomegalovirus-induced retinitis in human immunodeficiency virus type 1-infected subjects by using the polymerase chain reaction (1991)

In 13 of 16 AIDS patients with retinitis, a herpesviruslike infection was diagnosed by clinical investigation. In 12 of the 13 patients, human cytomegalovirus (HCMV) DNA was detected in 5 microliters of aqueous humor by using the polymerase chain reaction (PCR). In the aqueous humor of 12 control patients HCMV DNA could not be detected by PCR. PCR may be used to monitor specific antiviral long-term therapy in HCMV retinitis.
Structure and diffusion of excess Si atoms in<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:mi mathvariant="normal">Si</mml:mi><mml:msub><mml:mi mathvariant="normal">O</mml:mi><mml:mn>2</mml:mn></mml:msub></mml:mrow></mml:math> (2005)

Using gradient corrected density functional theory calculations, we have investigated the structure and diffusion of excess Si atoms in amorphous $\mathrm{Si}{\mathrm{O}}_{2}$, with comparisons to their behavior in $\ensuremath{\alpha}$-quartz. From the first principles calculations of their configuration, bonding, and energetics, we find that excess Si atoms can be fully incorporated into the amorphous oxide network while yielding oxygen vacancies. The incorporation turns out to gain energy as high as about $1.8\phantom{\rule{0.3em}{0ex}}\mathrm{eV}$, relative to the bond center state where the excess Si atom is located at a $\mathrm{Si}\text{\ensuremath{-}}\mathrm{O}$ bond center. Based on the results, we propose a novel mechanism for Si diffusion in amorphous $\mathrm{Si}{\mathrm{O}}_{2}$ in the presence of excess Si atoms, which involves the fourfold-coordinate ${\mathrm{Si}}^{2+}$ state creation via oxygen vacancy diffusion and pairing and its reconfiguration to the bond center state. The overall diffusion barrier is approximated to be $4.5--5.0\phantom{\rule{0.3em}{0ex}}\mathrm{eV}$, in good agreement with recent measurements. Our calculation results also predict that excess Si atoms, if they exist, may undergo diffusion with a moderate barrier of $<3.0\phantom{\rule{0.3em}{0ex}}\mathrm{eV}$ in $\ensuremath{\alpha}$-quartz.
Initial clinical experience with a new self-expanding nitinol stent for the treatment of intracranial cerebral aneurysms: the Cordis Enterprise stent. (2005)

In early clinical studies, the Cordis Enterprise stent performed well. The stent was able to be well visualized, deployed easily, could be repositioned if needed, and was accurately placed without technical difficulties. The closed cell design allowed all coils to be placed within the aneurysm and remain outside the flow of the parent artery. No periprocedural complications were encountered.
Omnidirectional emission from top-emitting organic light-emitting devices with microstructured cavity (2012)

We demonstrate optimized viewing-angle characteristics from top-emitting organic light-emitting devices by integrating a periodic microstructure into the cavity. A holographic lithography technique combined with filling process of the groove by spin coating of a polymer film has been employed to enable its periodically and gradually changed cavity length and suppress the viewing-angle dependence of the peak emission wavelength and intensity. The theoretical and experimental results support that the proposed microstructured cavity can resolve the angular-dependence effect in a very simple and effective way, and a desired omnidirectional emission has been obtained.
Isolation and characterization of polygalacturonase genes (pecA and pecB) from Aspergillus flavus (1995)

Two genes, pecA and pecB, encoding endopolyglacturonases were cloned from a highly aggressive strain of Aspergillus flavus. The pecA gene consisted of 1,228 bp encoding a protein of 363 amino acids with a predicted molecular mass of 37.6 kDa, interrupted by two introns of 58 and 81 bp in length. Accumulation of pecA mRNA in both pectin- or glucose-grown mycelia in the highly aggressive strain matched the activity profile of a pectinase previously identified as P2c. Transformants of a weakly aggressive strain containing a functional copy of the pecA gene produced P2c in vitro, confirming that pecA encodes P2c. The coding region of pecB was determined to be 1,217 bp in length interrupted by two introns of 65 and 54 bp in length. The predicted protein of 366 amino acids had an estimated molecular mass of 38 kDa. Transcripts of this gene accumulated in mycelia grown in medium containing pectin alone, never in mycelia grown in glucose-containing medium, for both highly and weakly aggressive strains. Thus, pecB encodes the activity previously identified as P1 or P3. pecA and pecB share a high degree of sequence identity with polygalacturonase genes from Aspergillus parasiticus and Aspergillus oryzae, further establishing the close relationships between members of the A. flavus group. Conservation of intron positions in these genes also indicates that they share a common ancestor with genes encoding endopolyglacturonases of Aspergillus niger.
Ultra-thin film nanostructured gallium arsenide solar cells (2014)

State-of-the-art III-V cells have reached the highest energy conversion efficiency among all types of solar cells. However, these cells are not applicable to widespread terrestrial solar energy system yet due to the high cost of epitaxial growth. Ultra-thin film absorbers with advanced light management is one of the most promising solutions to drive down the cost. In this paper, we present an ultra-thin film nano-window gallium arsenide (GaAs) solar cell design. This ultrathin cell consists of a nano-structured Al<sub>0.8</sub>Ga<sub>0.2</sub>As window layer on the front side to reduce the reflection and to trap the light, and a metal reflector on the back side to further increase the light path. The 300 nm thick GaAs cell with Al<sub>0.8</sub>Ga<sub>0.2</sub>As nano-window shows a broad band absorption enhancement from visible to near infrared (NIR), achieving a spectrally averaged absorption of 94% under normal incidence. In addition, this cell shows excellent angular absorption properties, achieving over 85% spectral averaged absorption at up to 60 degree off normal incidence. Meanwhile, this structure with planar junction and nano-window has solved the issue of low fill factor and low open-circuit voltage in nano-structured GaAs solar cell. A nano-window cell with a 3 μm thick GaAs junction demonstrated an open circuit voltage of 0.9V.
HOMENAJE AL PROFESOR RAFAEL HELIODORO VALLE (1979)

EN EL XX ANIVERSARIO DE SU MUERTE, LA FIGURA DEL MAESTRO RAFAEL HELIODORO VALLE, LITERATO, POETA, HISTORIADOR Y DIPLOMATICO, FUE RECORDADA EN UNA CEREMONIA EFECTUADA EN EL AUDITORIO SIMON BOLIVAR DEL PLANTEL JUSTO SIERRA DE LA ESCUELA NACIONAL PREPARATORIA. EL ACTO ESTUVO PRESIDIDO POR EL MAESTRO LEONARDO CURZIO RIVERA, COORDINADOR ACADEMICO Y CULTURAL DE LA ENP, EN REPRESENTACION DEL LICENCIADO ENRIQUE ESPINOZA SUNER, DIRECTOR GENERAL DE LA INSTITUCION, LA QUIMICA GUADALUPE FOROSTIETA, DIRECTORA DEL PLANTEL; EL SENOR ELISEO PEREZ CADALSO, EX-EMBAJADOR DE HONDURAS EN MEXICO Y RECIENTEMENTE NOMBRADO SECRETARIO DE RELACIONES EXTERIORES DE ESE PAIS CENTROAMERICANO. DESPUES DE UN BREVE ACTO MUSICAL A CARGO DEL CUARTETO DE LA ENP, FUE DESCUBIERTA UNA PLACA CONMEMORATIVA, DONADA POR LA EMBAJADA DE HONDURAS, EN UNA DE LAS AULAS DEL PLANTEL.
Influence of a static magnetic field on the photoluminescence of an ensemble of Nitrogen-Vacancy color centers in a diamond single-crystal (2009)

We investigate the electron spin resonance of an ensemble of Nitrogen-Vacancy (NV) color centers in a bulk diamond crystal. The four possible orientations of the NV-center in the lattice lead to different dependences on the magnitude and the orientation of an external static magnetic field. Experimental results obtained with a continuous microwave excitation are in good agreement with simulations. In addition, we observe that the average radiative lifetime of the NV color center is also modified when the external magnetic field is applied. This variation is explained by the mixing between mS = 0 and mS = $\pm$1 spin states of the NV-center with different radiative lifetimes, due to magnetic coupling. These results are of interest for a broad range of applications, such as spin-resonance-based magnetometry with a high-density ensemble of NV-centers
Self Bragg matched beam steering using the double color pumped photorefractive oscillator (1987)

A new method for steering light beams with automatic (self-aligning) Bragg matching is presented. This device enables, in principle, a large beam deflection range which is not limited by the Bragg condition. It is based on a double color pumped photorefractive oscillator. Two input beams of different colors induce and pump a dynamic four-wave mixing process in a photorefractive BaTiO3 crystal in which two other beams and a common grating are self-generated. Steering is achieved by wavelength tuning of one of the pump beams. A deflection range of about 1.7°, with an efficiency ranging from 50 to 90%, is measured for a wavelength difference Δλ of ±30 nm for the two pumps (using argon ion laser lines). A deflection of 4.7° with an efficiency of 10% is seen for Δλ=144.8 nm (corresponding to pumps at 488 and 632.8 nm).
Note on Attempts to Prepare Ring‐B Homomorphinan‐6‐ones by <i>Grewe</i> Cyclization from Octahydro‐1‐phenethylisoquinolines (1985)

Abstract Grewe cyclization of the N ‐formyl‐protected octahydroisoquinolin‐6‐one 1 prepared by conventional chemistry did not afford the expected homomorphinanone. The exclusive reaction product obtained in good yield was the α,β‐unsaturated N ‐formyloctahydroisoquinolin‐6‐one 2 , further converted by acid hydrolysis into the crystalline octahydroisoquinolin‐6‐one 8 .
Identity-Based Key Exchange on In-Vehicle Networks: CAN-FD & FlexRay (2019)

Security has become critical for in-vehicle networks as they carry safety-critical data from various components, e.g., sensors or actuators, and current research proposals were quick to react with cryptographic protocols designed for in-vehicle buses, e.g., CAN (Controller Area Network). Obviously, the majority of existing proposals are built on cryptographic primitives that rely on a secret shared key. However, how to share such a secret key is less obvious due to numerous practical constraints. In this work, we explore in a comparative manner several approaches based on a group extension of the Diffie-Hellman key-exchange protocol and identity-based authenticated key agreements. We discuss approaches based on conventional signatures and identity-based signatures, garnering advantages from bilinear pairings that open road to several well-known cryptographic constructions: short signatures, the tripartite Diffie-Hellman key exchange and identity-based signatures or key exchanges. Pairing-based cryptographic primitives do not come computationally cheap, but they offer more flexibility that leads to constructive advantages. To further improve on performance, we also account for pairing-free identity-based key exchange protocols that do not require expensive pairing operations nor explicit signing of the key material. We present both computational results on automotive-grade controllers as well as bandwidth simulations with industry-standard tools, i.e., CANoe, on modern in-vehicle buses CAN-FD and FlexRay.