gebhart/patrepeval huggingface dataset:
The incidence of cancer in schizophrenic patients. (1989)

A cohort of 6168 schizophrenic patients was followed from 1957 to 1984 to determine the incidence of cancer in these patients. In the male schizophrenic patients the incidence of cancer was found to be significantly reduced in comparison with the general Danish population. This reduction was especially marked for cancer in the respiratory system, cancer of the prostate and cancer of the bladder. In the female patients the overall incidence of cancer did not differ from that of the general Danish population, but there was an increased risk of cancer of the digestive tract, especially cancer of the pancreas and a slight increase of the risk of breast cancer. In the female patients the risk of respiratory cancers and cancer of the female genital organs, especially cancer of the uterine cervix, was reduced. These alterations of the incidence of cancer in schizophrenic patients cannot be ascribed to differences in diagnostic accuracy. As a possible explanation of these findings a reduced exposure to well known carcinogens such as cigarette smoke may be relevant. We speculate that exposure to neuroleptics such as phenothiazines and reserpine may also be part of the explanation for the findings.
Calspermin Gene Transcription Is Regulated by Two Cyclic AMP Response Elements Contained in an Alternative Promoter in the Calmodulin Kinase IV Gene (1995)

The transcript for the high-affinity Ca2+/calmodulin-binding protein calspermin is generated from the gene encoding Ca2+/calmodulin-dependent protein kinase IV only in postmeiotic germ cells during spermatogenesis. We demonstrate that this testis-specific calspermin transcript can be produced in heterologous cells by utilization of a promoter located in an intron of the calmodulin (CaM) kinase IV gene. Critical motifs within this promoter are two cyclic AMP response element (CRE)-like sequences located about -70 and -50 bp upstream of the transcriptional initiation site. Both CRE motifs are footprinted by the authentic testis-specific transcriptional activator CREM tau or by CREM tau present in adult testis nuclear extract. Whereas a 2.1-kb DNA fragment containing the calspermin promoter is inactive when transfected into NIH 3T3 cells, activity can be restored by cotransfection of CREM tau and protein kinase A or CaM kinase IV but not CaM kinase II alpha. Restoration of activity is greatly reduced by mutation of the two CRE motifs. Since CRE-like motifs have been identified in many genes uniquely expressed in postmeiotic germ cells, which contain abundant CREM tau protein, we suggest that CREM tau may function as one transcription factor responsible for the expression of postmeiotic germ cell-specific genes.
Modified katira gum for colon targeted drug delivery (2010)

Abstract The aim of the this study is to develop colon targeted drug delivery systems for Ibuprofen using grafted katira gum as a carrier. Polyacrylamide‐grafted katira gum was synthesized by grafting acrylamide onto katira gum in presence of varying concentration of ceric ammonium nitrate (CAN) as initiator. Elemental analysis, FTIR, TGA, DTA, DSC, and SEM were used to characterize the grafting of acrylamide onto katira gum. Matrix tablets containing various proportions of grafted katira gum were prepared by wet granulation method. All the formulations were evaluated for hardness, drug content, swelling index, and in vitro release studies in simulated gastric fluid, small intestinal fluid, and simulated colonic fluid with and without enzymes. Ibuprofen was used for controlled release study. The drug release mechanism was studied by fitting into Peppas model and was found to be supercase‐II transport. Matrix tablets containing 0.3 g of CAN/gm of acrylamide showed optimum value and retained its physical integrity in simulated gastric, small intestinal and colonic fluid, where as other composition disintegrated within 2 h of dissolution testing in pH 1.2 buffer, simulated gastric fluid. The results of this study indicates that Ibuprofen matrix tablet containing 60 wt % composition of the above grafted katira gum would be potential formulations in delivering the drug to the colon and the more susceptible for enzymatic degradation. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
PARAMETRIC RESONANCE CHARACTERISTICS OF ANGLE-PLY TWISTED CURVED PANELS (2008)

The present study deals with the dynamic stability of laminated composite pre-twisted cantilever panels. The effects of various parameters on the principal instability regions are studied using Bolotin's approach and finite element method. The first-order shear deformation theory is used to model the twisted curved panels, considering the effects of transverse shear deformation and rotary inertia. The results on the dynamic stability studies of the laminated composite pre-twisted panels suggest that the onset of instability occurs earlier and the width of dynamic instability regions increase with introduction of twist in the panel. The instability occurs later for square than rectangular twisted panels. The onset of instability occurs later for pre-twisted cylindrical panels than the flat panels due to addition of curvature. However, the spherical pre-twisted panels show small increase of nondimensional excitation frequency.
Mutational Analysis of Target Enzyme Recognition of the β-Trefoil Fold Barley α-Amylase/Subtilisin Inhibitor (2005)

The barley alpha-amylase/subtilisin inhibitor (BASI) inhibits alpha-amylase 2 (AMY2) with subnanomolar affinity. The contribution of selected side chains of BASI to this high affinity is discerned in this study, and binding to other targets is investigated. Seven BASI residues along the AMY2-BASI interface and four residues in the putative protease-binding loop on the opposite side of the inhibitor were mutated. A total of 15 variants were compared with the wild type by monitoring the alpha-amylase and protease inhibitory activities using Blue Starch and azoalbumin, respectively, and the kinetics of binding to target enzymes by surface plasmon resonance. Generally, the mutations had little effect on k(on), whereas the k(off) values were increased up to 67-fold. The effects on the inhibitory activity, however, were far more pronounced, and the K(i) values of some mutants on the AMY2-binding side increased 2-3 orders of magnitude, whereas mutations on the other side of the inhibitor had virtually no effect. The mutants K140L, D150N, and E168T lost inhibitory activity, revealing the pivotal role of charge interactions for BASI activity on AMY2. A fully hydrated Ca(2+) at the AMY2-BASI interface mediates contacts to the catalytic residues of AMY2. Mutations involving residues contacting the solvent ligands of this Ca(2+) had weaker affinity for AMY2 and reduced sensitivity to the Ca(2+) modulation of the affinity. These results suggest that the Ca(2+) and its solvation sphere are integral components of the AMY2-BASI complex, thus illuminating a novel mode of inhibition and a novel role for calcium in relation to glycoside hydrolases.
Fast algorithms in active noise or vibration control (2003)

Algorithms are presented for active cancellation of acoustic or mechanical fields with sinusoidal components. The first method is an efficient but not very fast algorithm using Fourier transforms. Experimental results on a multidimensional, multifrequency stationary mechanical problem are given. An adaptive algorithm is presented for cancellation of nonstationary fields with components that are known sinusoids, not necessary harmonic with each other, having magnitude or phase that can be slowly varying. The proposed method does not need synchronous sampling. An antiphase field is produced by the asynchronous synthesis and the updating of each sinusoidal component using iterative formulation and a very simple algorithm. Experimental results are given.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Molecular cloning, expression, and characterization of secretory phospholipase A<sub>2</sub> in tobacco (2005)

Phospholipase A2 (PLA2) activity was investigated in various tissues of tobacco (Nicotiana tabacum). PLA2 activity in the flower was 15 times higher than that in the leaf, stem, and root. PLA2 activity in the flower appears to have originated from both Ca2+-dependent and -independent PLA2. A cDNA clone for protein with homology to animal secretory PLA2 (sPLA2), denoted as Nt PLA2, was isolated from the tobacco flower. The cDNA of Nt PLA2 encoded a mature protein of 127 amino acid residues with a putative signal peptide of 30 residues. The amino acid sequence for mature Nt PLA2 contains 12 cysteines, a Ca2+ binding loop, and a catalytic domain that are commonly conserved in animal sPLA2. The Nt PLA2 mRNA was mainly expressed in the root and stem of tobacco. The recombinant Nt PLA2 was expressed as a fusion protein with thioredoxin in Escherichia coli. From the bacterial cell lysate, the fusion protein was recovered in soluble form and cleaved by Factor Xa proteinase. Then the recombinant mature Nt PLA2 was purified by ion exchange chromatography. It was discovered that the purified Nt PLA2 essentially requires Ca2+, for the enzyme activity when the activity was determined using mixed-micellar phospholipid substrates with sodium cholate. The optimal activity of Nt PLA2 was at pH 8-10 when PC was used as a substrate.
TW-37, a Small-Molecule Inhibitor of Bcl-2, Inhibits Cell Growth and Induces Apoptosis in Pancreatic Cancer: Involvement of Notch-1 Signaling Pathway (2009)

Overexpression of Bcl-2 family proteins has been found in a variety of aggressive human carcinomas, including pancreatic cancer, suggesting that specific agents targeting Bcl-2 family proteins would be valuable for pancreatic cancer therapy. We have previously reported that TW-37, a small-molecule inhibitor of Bcl-2 family proteins, inhibited cell growth and induced apoptosis in pancreatic cancer. However, the precise role and the molecular mechanism of action of TW-37 have not been fully elucidated. In our current study, we found that TW-37 induces cell growth inhibition and S-phase cell cycle arrest, with regulation of several important cell cycle-related genes like p27, p57, E2F-1, cdc25A, CDK4, cyclin A, cyclin D1, and cyclin E. The cell growth inhibition was accompanied by increased apoptosis with concomitant attenuation of Notch-1, Jagged-1, and its downstream genes such as Hes-1 in vitro and in vivo. We also found that down-regulation of Notch-1 by small interfering RNA or gamma-secretase inhibitors before TW-37 treatment resulted in enhanced cell growth inhibition and apoptosis. Our data suggest that the observed antitumor activity of TW-37 is mediated through a novel pathway involving inactivation of Notch-1 and Jagged-1.
Multiple Point Ion Current Diagnostics in an HCCI Engine (2004)

<div class="htmlview paragraph">Interest in ion current sensing for HCCI combustion arises when a feedback signal from some sort of combustion sensor is needed in order to determine the state of the combustion process. A previous study has revealed that ion current sensors in the form of spark plugs can be used instead of expensive piezoelectric transducers for HCCI combustion sensing. Sufficiently high ion current levels were achieved when using relatively rich mixtures diluted with EGR. The study also shows that it is not the actual dilution per se but the actual air/fuel equivalence ratio which is important for the signal level. Conclusions were made that it is possible to obtain information on combustion timing and oscillating wave phenomena from the measurements. However, the study showed that the ion current is local compared to the pressure which is global in the combustion chamber. This observation triggered the present study where the aim is to investigate the ion current at different locations in the combustion chamber. The ion current was measured simultaneously at seven locations in the combustion chamber. In order to achieve this, 6 spark plugs were fitted circumferentially in a spacer placed between the cylinder block and the head. The seventh spark plug was placed in the cylinder head. Individual DC sources of 85 volts were applied across the spark plug gaps. The present study indicates that the combustion timing seems to be dependent on the wall temperature at the different spark plug locations. The largest difference in timing between different locations in the combustion chamber was 2 CAD. The ion current amplitude varies with different spark plug locations up to 1.5 μA. The signal strength increases with decreasing air/fuel ratio and is also affected by dilution.</div>
Spinal Cord Stimulation (2006)

Patients with spinal cord injury have an increased risk of developing respiratory tract infections as the result of expiratory muscle paralysis and consequent inability to cough. We have developed a method by which the expiratory muscles can be activated via lower thoracic and upper lumbar spinal cord stimulation to produce an effective cough mechanism. In a tetraplegic patient who required frequent (8.57+/-2.3 times per week [mean+/-SEM]) caregiver assistance to facilitate airway clearance and expectoration of secretions, three epidural electrodes were applied in the T9, T11, and L1 spinal cord regions. During stimulation at the T9 and L1 levels, airway pressures were 90 and 82 cm H2O, respectively. Peak expiratory flow rates were 6.4 L/s and 5.0 L/s; respectively. During combined (T9+L1) stimulation, airway pressure and expiratory flow rate increased to 132 cm H2O and 7.4 L/s, respectively. Addition of the third lead did not result in further increases in pressure generation. These values are characteristic of those observed with a normal subject. Because the patient is able to trigger the device independently, he no longer requires caregiver support for airway management. If confirmed in additional patients, spinal cord stimulation may be a useful method to restore an effective cough mechanism in patients with spinal cord injury.
St. Jude Medical Trifecta  aortic valve perioperative performance in 200 patients (2013)

The Trifecta valve offers good clinical results and excellent haemodynamic performance. Special care must be taken to avoid oversizing, which can lead to difficulty in implantation and can produce gradient increases due to an excess of prosthetic leaflet tissue.
A model of scalable distributed network performance management (2004)

Quality of service in IP networks necessitates the use of performance management. As Internet continues to grow exponentially, a management system should be scalable in terms of network size, speed and number of customers subscribed to value-added services. This article proposes a flexible, scalable, self-adapting model for managing large-scale distributed network. In this model, Web services framework is used to build the software architecture and XML is used to build the data exchange interface. Policy-based hierarchical event-processing mechanism presented by this paper can efficiently balance the loads and improve the flexibility of the system. The prediction algorithm adopted by this model can predict the network performance more effectively and accurately.
Mobile Water Kit (MWK): a smartphone compatible low-cost water monitoring system for rapid detection of total coliform and E. coli (2014)

In this work, we have developed and demonstrated a rapid and low-cost water monitoring sensor that can simultaneously detect total coliform and Escherichia coli (E. coli) bacteria in contaminated drinking water samples. The test method, called Mobile Water Kit (MWK), comprises a set of custom chemical reagents that would serve as colorimetric or fluorometric chemosensors, syringe filter units and a smartphone platform that would serve as the detection/analysis system. The MWK provides information about the presence/absence of total coliform and E. coli in water samples. The MWK has preliminarily been tested for its selectivity, sensitivity and accuracy, with samples of known concentrations of bacteria. The MWK has also been tested with contaminated water samples collected during the two field trials conducted in Canada and India, and the obtained results were confirmed with conventional laboratory methods. With this MWK, we were able to detect the total coliform and E. coli bacteria in water samples within 30 min or less, depending on the concentration of the bacteria. For one of the field samples, the MWK was able to detect the total coliform within 35 s, which is faster than any rapid test methods available in the market. This new technology can dramatically improve the response times for the outbreak of water-borne diseases and will help water managers and individuals to assess the quality of water sources.
Characterization of ultrashort pulse formation in passively mode-locked fiber lasers (1992)

Pulse formation in an all-solid-state passively mode-locked neodymium glass fiber laser is investigated by employing characterization techniques in the time, optical, and radio-frequency domains. The pulses are generated by a combination of passive amplitude modulation arising from nonlinear polarization evolution and passive frequency modulation due to quasi-soliton-like pulse shaping. Several distinct operation modes for ultrashort pulse generation are described and pulses as short as 38 fs are directly generated in the cavity.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Common Genomic Variation in the<i>APOC3</i>Promoter Associated With Variation in Plasma Lipoproteins (1997)

We hypothesized that common genomic variation that affected the expression and/or function of the products of the APOC3, APOE, FABP2, and PON1 genes would be associated with variation in biochemical phenotypes in a previously unstudied human sample. We determined genotypes of functional genomic variants of APOC3, APOE, FABP2, and PON1 in 509 adult aboriginal Canadians from an isolated community in Northern Ontario. We tested for genotype associations with plasma lipoprotein traits. We found that (1) common variation at nucleotide -455 of the APOC3 promoter was associated with variation in plasma triglycerides (P = .006) and (2) common variation of APOE determining plasma isoforms of apo E was associated with variation in plasma apo B (P = .009). Analysis of subjects classed by APOC3 markers showed that homozygosity for presence of a C at nucleotide -455 and a T at nucleotide -482 was associated with significantly increased plasma triglycerides in both men and women. Furthermore, this allele was approximately twice as frequent in subjects within the highest quartile of plasma triglycerides as in subjects within the lowest quartile. Since the DNA variation detected by the APOC3 markers affects in vitro expression of the gene product, it is possible that the marker itself caused the associations. However, the associations could also have resulted from linkage disequilibrium with other functional variants in APOC3 or the closely linked APOA1 and/or APOA4 genes.
NAD <sup>+</sup> in aging, metabolism, and neurodegeneration (2015)

Nicotinamide adenine dinucleotide (NAD(+)) is a coenzyme found in all living cells. It serves both as a critical coenzyme for enzymes that fuel reduction-oxidation reactions, carrying electrons from one reaction to another, and as a cosubstrate for other enzymes such as the sirtuins and poly(adenosine diphosphate-ribose) polymerases. Cellular NAD(+) concentrations change during aging, and modulation of NAD(+) usage or production can prolong both health span and life span. Here we review factors that regulate NAD(+) and discuss how supplementation with NAD(+) precursors may represent a new therapeutic opportunity for aging and its associated disorders, particularly neurodegenerative diseases.
Glass-coated hard-magnetic Fe - Co - Cr microwires (1997)

Glass-coated hard-magnetic Fe - Co - Cr microwires were prepared by Taylor's technique with subsequent annealing at different temperatures. The diameter of the metallic core is . The annealing temperature dependence of the coercive force is reported; the maximum coercivity is about 200 Oe after an annealing at for one hour. Such materials may be useful in locally magnetizing devices and magnetic force microscopy.
Design, modeling, fabrication and testing of a MEMS capacitive bending strain sensor (2006)

Presented herein are the design, modelling, fabrication and testing of a MEMSbased capacitive bending strain sensor utilizing a comb drive. This sensor is designed to be integrated with a telemetry system that will monitor changes in bending strain to assist orthopaedic surgeons with the diagnosis of spinal fusion. ABAQUS/CAE version 6.5 finite element analysis (FEA) modelling software was used to predict sensor actuation, capacitance output and the avoidance of material failure. Highly doped boron silicon wafers with a low resistivity were fabricated into an interdigitated finger array employing deep reactive ion etching (DRIE) to create 150 µm sidewalls with 25 µm spacing between the adjacent fingers. For testing, the sensor was adhered to a steel beam, which was subjected to four-point bending. This mechanically changed the spacing between the interdigitated fingers as a function of strain. As expected, the capacitance output increased as an inverse function of the spacing between the interdigitated fingers, beginning with an initial capacitance of 7.56 pF at the unstrained state and increasing inversely to 17.04 pF at 1571 µε of bending strain. The FEA and analytical models were comparable with experimental data. The largest differential of 0.65 pF or 6.33% occurred at 1000 µε.
Photochemical surface modification of polystyrene in the presence of cerium (IV) ammonium nitrate: Improved binding of proteins, amines and mercaptans in the presence of detergent (1993)

Biokemi
Active Antenna Module for Low-Cost Electronically Scanned Phased Arrays (2008)

This paper describes a low-cost compact active antenna module that includes transmit/receive/mixer electronics and a dual-polarized antenna element for half-duplex operation at 10 GHz. The system-in-package module has been fabricated in a ball-grid-array package. It is particularly suited for large low-cost low-power phased-array applications. Measurements at IF of single element gain show cross-pol reduced 18 dB. A small compact array was fabricated and measured. Simulations show that coupling between modules in a tightly packed infinite array caused a small reduction in scan range.