gebhart/patrepeval huggingface dataset:
An Open Architecture Corporate Electronic Publishing Platform (1989)

Corporate Electronic Publishing (CEP) encompasses more than the primitive capabilities of desktop publishing systems. It also includes networking and, in its optimal form, provides a platform for addressing a wide-ranging set of corporate documentation requirements. At AT&T Bell Laboratories we have evolved a platform for CEP consisting of AT&T's UNIX® operating system, the Datakit® virtual circuit switch, the Documenter's Workbench® and Graphics Workbench software, and the Adobe System, Inc. PostScript™ page description language. We cite real-life examples in which authors and printing facilities at geographically dispersed locations participated in cooperative efforts using the platform. We describe new work in progress that builds on this platform and addresses needs in illustration, photographic reproduction and plotting.
Automatic Prediction of Discourse Connectives (2017)

Accurate prediction of suitable discourse connectives (however, furthermore, etc.) is a key component of any system aimed at building coherent and fluent discourses from shorter sentences and passages. As an example, a dialog system might assemble a long and informative answer by sampling passages extracted from different documents retrieved from the Web. We formulate the task of discourse connective prediction and release a dataset of 2.9M sentence pairs separated by discourse connectives for this task. Then, we evaluate the hardness of the task for human raters, apply a recently proposed decomposable attention (DA) model to this task and observe that the automatic predictor has a higher F1 than human raters (32 vs. 30). Nevertheless, under specific conditions the raters still outperform the DA model, suggesting that there is headroom for future improvements.
Expression of Phage Transcription in P2 Lysogens Infected with Helper-Dependent Coliphage P4 (1974)

The DNA of helper-dependent coliphage P4 and the DNA of its helper-P2-show no detectable sequence homology as measured by DNA.DNA hybridization. The lack of cross-hybridization permits direct analysis of P4 as well as of P2 transcription in P4-infected P2 lysogens by RNA.DNA hybridization. P4-transactivated P2 transcription can be detected around 20 min after P4 infection of the P2 lysogen and the rate (per infected cell) of that transcription becomes equal to that of the P4 transcription at the end of the latent period of P4. Furthermore, P4 transcription appears to be stimulated by the presence of the helper. Conceivably, P2 codes for a stimulator of P4 transcription. Rifamycin has been used to investigate the role of the host RNA polymerase during P4 transactivation of P2 transcription. The results exclude the participation of a P4-coded RNA polymerase and indicate that the original host RNA polymerase is responsible for the bulk of P4 and P2 transcription during transactivation.
Suppression of Pain in Trigeminal Neuropathy by Electric Stimulation of the Gasserian Ganglion (1986)

Lesions of the peripheral part of the trigeminal nerve may cause trigeminal neuropathy associated with severe pain. Such pain usually does not respond to carbamazepine and analgesics, and it is continuous and lacks the characteristic paroxysmal character of tic douloureux. These patients often present with complex changes of facial sensibility in the form of dysesthesia, hyperalgesia, and allodynia. The pain sometimes responds favorably to transcutaneous nerve stimulation, but direct stimulation of the trigeminal ganglion and rootlets via an implanted electrode provides a greater likelihood of pain relief. Fourteen patients diagnosed as having painful trigeminal neuropathy received implants of a gasserian ganglion-stimulating electrode. The mean follow-up period is 4 years (range, 1 to 7 years). Eleven of the patients have retained the pain-relieving effect, and 1 had pain disappear without further stimulation. Eight of the patients estimated their pain relief to be complete or very good. There were no serious complications, but in several of the patients the electrode had to be exchanged because the insulation of the lead wires broke. For the selection of patients for permanent electrode implantation, a method has been developed for trial stimulation via a percutaneous electrode introduced into the trigeminal cistern. Temporary trial stimulation can be performed for several days. It is concluded that stimulation of the trigeminal ganglion and rootlets with the aid of an implanted electrode may effectively relieve certain forms of trigeminal pain that are otherwise extremely difficult to manage.
Effects of KCl, MgCl2 and CaCl2 Concentrations on the Monomer-Polymer Equilibrium of Actin in the Presence and Absence of Cytochalasin D1 (1984)

Critical metal concentrations of KCl, MgCl2, and CaCl2 below which actin cannot exist in filamentous form at equilibrium were estimated to be approximately 8 mM, 0.2 mM, and 0.4 mM, respectively, when actin, 0.5 mg/ml, was incubated for a long time at pH 8.0 and 25 degrees C. These values were obtained by viscosity, UV absorbance and pyrene-labeled actin fluorescence measurements. In the case of CaCl2, viscosity measurements resulted in a larger critical concentration, 0.7 mM. It turned out that actin filaments formed in a low concentration of CaCl2 were easily fragmented by shearing force. The higher the actin concentration, the lower the critical metal concentration was. The critical concentrations of actin above which actin can exist as a polymer at equilibrium became larger as the KCl, MgCl2, and CaCl2 concentrations were lower. It is advisable to add 0.05-0.1 mM CaCl2 to a depolymerization solution to obtain a concentrated monomeric solution. In the presence of cytochalasin D, which preferentially blocks the elongation at the barbed end of actin filaments, the critical concentrations of KCl and CaCl2 were the same as in its absence. On the other hand, the critical concentration of MgCl2 was increased and the extent of polymerization was decreased by cytochalasin D. In the presence of 50 mM KCl and 1 microM cytochalasin D, 0.01-0.1 mM MgCl2 markedly decreased the extent of polymerization of actin at equilibrium, where the critical actin concentration was tenfold increased. It is suggested that Mg2+ enhances dissociation of actin monomers at the pointed end of an actin filament.
Disease Course of Patients with X-linked Retinitis Pigmentosa due to<i>RPGR</i>Gene Mutations (2007)

Patients with X-linked retinitis pigmentosa due to RPGR mutations lose visual acuity and visual field more rapidly than do patients with dominant retinitis pigmentosa due to RHO mutations.
The impact of structural composite materials. Part 1: ballistic impact (2012)

Composite materials are increasingly being used in the design of structures that will be subjected to high-velocity impact during their lifetime. In this review we will look at the recent advances in our understanding of how rigid composite materials behave under high-velocity impact. In particular, this review will focus on rigid structural composites such as carbon fibre reinforced plastic and glass fibre reinforced plastic laminates and what we have learned with regards to how they respond under ballistic-loading conditions. We will focus on a velocity regime that includes impacts from explosively-driven fragments, ice particles and bullets. The hypervelocity-impact response and how these materials behave under one-dimensional shock loading will be studied in an accompanying review (Part II).
NMR Conformational Study of Aminoalkylbenzamides, Aminoalkyl‐<i>o</i>‐anisamides, and Metoclopramide, a Dopamine Receptor Antagonist (1984)

Abstract The conformational behaviour of metoclopramide, a neuroleptic benzamide, and model compounds was investigated byt 1 H‐NMR spectroscopy. An intramolecular amide‐methoxy H‐bond is shown to exist in CDCl 3 ‐solution, but not in D 2 O‐solution, independently of the length and protonation state of the basic side‐chain. This H‐bond creates a virtual cycle which may be a key feature for the binding of neuroleptic benzamides to the dopamine receptor. The conformational behaviour of the aminoethyl side‐chain is shown to be markedly condition‐dependent. For metoclopramide and its analogues in their protonated form, the gauche ‐ and trans ‐ rotamers have identical energies in D 2 O‐as well as in CDCl 3 ‐solutins. For the non‐protonated molecules, the trans ‐rotamer is favoured in D 2 O‐solutin, while the gauche ‐rotamer is favoured in CDCl 3 ‐solution (ΔG°≃|0.5|kcal/mol in both cases). The side‐chain conformation of neuroleptic benzamides is discussed in terms of receptor affinity.
Human inter-alpha-trypsin inhibitor. Isolation and characterization of heavy (H) chain cDNA clones coding for a 383 amino-acid sequence of the H chain. (1988)

A cDNA library cloned in lambda gt 11 expression vector was screened with specific anti-inter-alpha-trypsin inhibitor (ITI) heavy (H) chain antiserum. Among seven positive clones selected, two overlapping clones were sequenced. The corresponding consensus sequence encompasses a stretch of bases with one single open reading frame, and the deduced amino-acid sequence displays no homology with the full length cDNA-deduced amino-acid sequence of ITI-light (L) chain. Furthermore, analysis of poly A+ mRNAs hybrid-selected by the corresponding cDNA from clone lambda gt11 revealed an immunoprecipitable polypeptide of Mr 91,000. Northern blot analysis showed a single population of mRNAs of 3.3 kb. These data provide new evidence for the presence of distinct H and L chains in the 180 kDa ITI molecule.
Terminal and Intermediate Combustion Products Observed from 2.0 to 5.0 <i>μ</i>m in Flame/Furnace Infrared Emission Spectrometry (1992)

A computer-controlled, dispersive, scanning spectrometer with a wavelength range from 1 to 15 μm is described and used to study the flame/furnace infrared emission (FIRE) spectra of combustion products formed in a small analyte/air flame and in an electrically heated furnace (570°C), operated with and without a column of heated hopcalite (370°C). When lead selenide was used as the detector, the emission spectra of the combustion products of pentane, benzene, dichloromethane, and methanol could be measured over the wavelength range from 2 to 5 μm. In addition to discrete emission bands from terminal combustion products such as CO 2 , H 2 O, and HCl, discrete emission from CO (4.6–4.9 μm) and continuum emission associated with soot formation were also observed under oxygen-limited combustion of benzene, dichloromethane, and possibly pentane. Bands centered at approximately 3.3 μm (3030 cm −1 ) and 3.5 μm (2857 cm −1 ) were observed in several spectra and attributed to C-H stretching in intermediate combustion products, with the 3.5- μm band being assigned to the stretching of the carbonyl hydrogen of aldehydes (formaldehyde, in particular). On the basis of these results, the “anomalous emission” observed at 3.8 μm in previous studies employing electrothermal excitation is attributed either to the presence of formaldehyde or to the formation of particulate carbon, which are both associated with conditions favoring the incomplete combustion of hydrocarbons.
Enhancement of granulocyte chemiluminescence with hydroxyl radical scavengers (1979)

Addition of hydroxyl radical scavengers (benzoate, ethanol, and mannitol) to granulocyte chemiluminescent reactions significantly enhanced light generation without altering granulocyte oxygen consumption or superoxide production.
Oct4 resetting by Aurkb–PP1 cell cycle axis determines the identity of mouse embryonic stem cells (2016)

In embryonic stem cells (ESCs), cell cycle regulation is deeply connected to pluripotency. Especially, core transcription factors (CTFs) which are essential to maintaining the pluripotency transcription programs should be reset during M/G1 transition. However, it remains unknown about how CTFs are governed during cell cycle progression. Here, we describe that the regulation of Oct4 by Aurora kinase b (Aurkb)/protein phosphatase 1 (PP1) axis during the cell cycle is important for resetting Oct4 to pluripotency and cell cycle related target genes in determining the identity of ESCs. Aurkb starts to phosphorylate Oct4(S229) at the onset of G2/M phase, inducing the dissociation of Oct4 from chromatin, whereas PP1 binds Oct4 and dephosphorylates Oct4(S229) during M/G1 transition, which resets Oct4-driven transcription for pluripotency and the cell cycle. Furthermore, Aurkb phosphormimetic and PP1 binding-deficient mutations in Oct4 disrupt the pluripotent cell cycle, lead to the loss of pluripotency in ESCs, and decrease the efficiency of somatic cell reprogramming. Based on our findings, we suggest that the cell cycle is directly linked to pluripotency programs in ESCs. [BMB Reports 2016; 49(10): 527-528].
Human Trabecular Meshwork Cells Express Functional Serotonin-2A (5HT<sub>2A</sub>) Receptors: Role in IOP Reduction (2006)

Strong signals for 5HT2A and 5HT2B receptor mRNAs were detected in h-TM cells. The receptors that coupled to PI hydrolysis and [Ca2+]i mobilization in h-TM cells were the 5HT2A receptor subtype, which also significantly lowered IOP in a primate model. These receptors may mediate the ocular hypotensive actions of 5HT2A agonists.
Novel Isoforms of Mouse Myelin Basic Protein Predominantly Expressed in Embryonic Stage (1993)

Myelin basic protein (MBP), a major protein of myelin, is thought to play an important role in myelination, which occurs postnatally in mouse. Here we report that the MBP gene is expressed from the 12th embryonic day in mouse brain and that most of the predominant embryonic isoforms are not those reported previously. These isoforms have a deletion of a sequence encoded by exon 5 from the well-known isoforms. These isoforms show a unique developmental profile, i.e., they peak in the embryonic stage and decrease thereafter. In jimpy, a dysmyelinating mutant, the level of these isoforms remains high even in the older ages. These results suggest that MBPs have heretofore unknown functions unrelated to myelination before myelinogenesis begins. The possible presence of 18 isoforms of MBP mRNA, which are classified into at least three groups with different developmental profiles, is also reported here.
Risk factors for cardiac events in patients with Brugada syndrome (2016)

Inducible ventricular arrhythmias on EPS, spontaneous type 1 Brugada ECG, and family history of SCD or syncope indicate a high risk of future cardiac events in patients with Brugada syndrome. Spontaneous type 1 Brugada ECG significantly increased the risk of future cardiac events in patients without family history of SCD.
Effects of an exopolysaccharide (kefiran) on lipids, blood pressure, blood glucose, and constipation (2004)

Lactobacillus kefiranofaciens was reported to produce an exopolysaccharide named kefiran. In the present study, we developed a new medium, rice hydrolyzate (RH) medium, for the culture of L. kefiranofaciens. Structural analyses revealed that the exopolysaccharide produced by L. kefiranofaciens from RH medium was composed of a hexasaccharide repeating unit, and essentially identical to the kefiran reported in previous studies. A study on the effects of kefiran in animals demonstrated that kefiran significantly suppressed increase of blood pressure and reduced the serum cholesterol levels in SHRSP/Hos rats when subjects consumed excessive dietary cholesterol. Kefiran supplementation demonstrated the ability to significantly lower blood glucose in KKAy mice. In addition, the administration of kefiran in constipated SD rats caused an obvious improvement in the levels of fecal moisture and wet weights of feces. These results suggest that kefiran could be used as a functional food to prevent some commonly occurring diseases.
Effect of TMEDA on Iron-Catalyzed Coupling Reactions of ArMgX with Alkyl Halides (2009)

A new reaction mechanism for the iron-catalyzed cross-coupling reaction of ArMgX with alkyl halides using (TMEDA)FeAr(2) and (TMEDA)Fe(Ar)Br is proposed on the basis of the isolation and reaction of these organoiron intermediates.
REVIEWS (1951)

Journal Article REVIEWS Get access Collected Poems of Sir Thomas Wyatt. Edited with an introduction by KENNETH MUIR. Pp. xIviii+298 (The Muses‘ Library). London: Routledge and Kegan Paul, 1949. 10s. 6d. net. D. W. HARDING D. W. HARDING Search for other works by this author on: Oxford Academic Google Scholar The Review of English Studies, Volume II, Issue 5, 1951, Pages 162–164, https://doi.org/10.1093/res/II.5.162 Published: 01 January 1951
Physical and genetic characterization of Rhizobium meliloti symbiotic mutants. (1983)

A set of 19 symbiotic mutants of Rhizobium meliloti obtained by a Tn5 "suicide plasmid" mutagenesis procedure was characterized genetically and physically. As part of this characterization, we showed that R. meliloti strain 1021, like other R. meliloti strains, contains a very large indigenous plasmid (greater than 300 Md) that carries the structural genes for nitrogenase (nifHDK genes). Among the 19 symbiotic mutations studied, at least six were shown to reside on the megaplasmid. By a "walking procedure" we obtained from a cosmid clone bank a set of overlapping cosmids that contained megaplasmid sequences contiguous to nifHDK. A 90 kb region of contiguous DNA from these cosmids was used to probe the mutant strains for rearrangements within this region. The same six mutations that were located on the megaplasmid mapped within the 90 kb region examined, which included the structural genes for nitrogenase (nifHDK). A majority of the mutations characterized in this study could not be correlated with a bona fide Tn5 insertion into a symbiotic gene.
Mobile agent-based policy management for wireless sensor networks (2005)

Wireless sensor network is a revolution of information sensing and collecting. This kind of networks is composed of hundreds and thousands of sensor nodes in small size with ubiquitous sensing and computing capabilities. The task of management of wireless sensor networks in environments with hundreds and thousands of sensor nodes is very complex. Until now, wireless sensor networks and their applications have been developed but with the management research in the germinal stages. In this paper, we describe a management architecture for wireless sensor network that combines mobile agent with policy technologies, and take into account the restrict physical resources of this type of network in the form of policies, such as energy and computing power, imbalance of network flow, and faults caused by nodes unavailable. Then the paper proposes the hierarchical architecture of policy management and mobile agent-based network management structure.
Calcium‐dependent interaction of annexin I with annexin II and mapping of the interaction sites (1999)

Annexins are multifunctional intracellular proteins with Ca2+- and phospholipid-binding properties. Their structures consist of four conserved repeat domains that form the core and a diverse N-terminal tail, from which their functional differences may arise. We searched for cellular proteins that interact with the N-terminal tail plus domain I of annexin I (ANX1) by using the yeast two-hybrid method. Screening of a HeLa cell cDNA library yielded annexin II (ANX2) cDNA. The interaction between ANX1 and ANX2 also occurred in vitro in a Ca2+-dependent manner. Mapping of the interaction sites revealed that interaction between domain I of ANX1 and domain IV of ANX2 was stronger than the other combinations.
Growth and metabolism of murine and bovine embryos in bovine uterine flushing-supplemented culture media. (1996)

The aim of this study was to compare the development and metabolic activity of cultured murine and bovine embryos in 2 standard media (HAM F-10 and RPMI) in the presence or absence of bovine uterine flushings. Murine morulae (n = 653) and day 7 bovine embryos (n = 273) were cultured for 18 h or 36 h in either HAM F-10 or RPMI in the presence or absence of bovine uterine flushings. After culture, the development, quality, and metabolic activity (glucose utilization or methionine uptake and incorporation) of embryos was assessed. It was found that HAM F-10 (without uterine flushings) was a more suitable medium than RPMI for optimal development and metabolism of murine and bovine embryos. Poor quality and development, as well as decreased metabolism, were evident after culture of murine embryos in RPMI; in contrast, this medium had no adverse effects on bovine embryos in culture. Supplementation of HAM F-10 with bovine uterine flushings improved the growth of murine embryos and the protein synthesis (as measured by an increased methionine incorporation) for both murine and bovine embryos. However, supplementation with bovine uterine flushings could not overcome deficiencies of an inappropriate medium (RPMI) for murine embryos. Supplementation of a well-defined culture medium with uterine flushings increased metabolism of embryos in culture, and thus might help to increase pregnancy rates after transfer of such embryos to recipient cows.
Lack of correlation between cytotoxicity of agonists and antagonists of platelet activating factor [paf-acether] in neoplastic cells and modulation of [3H]-paf-acether binding to platelets from humans in vitro. (1988)

The 3 ether-lipids ET-18-OCH3, SRI 63-154 and paf-acether, the TLP BM 41.440, the ester-linked 2-LPC and CV-3988, were tested for cytostatic/antiproliferative [3H]-thymidine uptake) and cytotoxic (trypan blue dye exclusion, HTCA) activity in 11 neoplastic human cell lines (U 698-M, Nall-1, Su-DHL-4, RPMI 8226, K 562-4, Li-A, HTB-47, HTB-38, CCL218, 85 HG-59, 85 HG-63) and 1 ALL in vitro. 2-LPC and paf-acether showed either no, or only minor, CV-3988 varying activity. There were no significant differences in the activity of ET-18-OCH3, SRI63-154 and BM 41.440, which showed IC50- and LC50-values of less than or equal to 10 micrograms/ml after incubation periods greater than or equal to 48 hours with or during continuous exposure to the cells. The latter three compounds were then tested for interaction with [3H]-paf-acether binding to intact human platelets: ET-18-OCH3 and SRI63-154 reduced [3H]-paf-acether binding in a time-dependent manner. BM 41.440 did not show this interaction. Thus, since the in vitro cytotoxicity of these lipids did not correlate with their modulation of [3H]-paf-acether binding to human platelets, it was concluded that cytotoxicity of ether-lipids is not mediated by specific paf-acether binding sites similar to those present on human platelets. This finding is important for the future design of antineoplastic lipids.
Hypocholesterolemic Agents. VI.<sup>1</sup> A- and B-Ring-Modified Azacholesterols (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHypocholesterolemic Agents. VI.1 A- and B-Ring-Modified AzacholesterolsP. D. Klimstra, R. E. Ranney, and R. E. CounsellCite this: J. Med. Chem. 1966, 9, 3, 323–326Publication Date (Print):May 1, 1966Publication History Published online1 May 2002Published inissue 1 May 1966https://pubs.acs.org/doi/10.1021/jm00321a013https://doi.org/10.1021/jm00321a013research-articleACS PublicationsRequest reuse permissionsArticle Views32Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts