gebhart/patrepeval huggingface dataset:
Quantitative imaging of basic functions in renal (patho)physiology (2006)

Multiphoton fluorescence microscopy offers the advantages of deep optical sectioning of living tissue with minimal phototoxicity and high optical resolution. More importantly, dynamic processes and multiple functions of an intact organ can be visualized in real time using noninvasive methods, and quantified. These studies aimed to extend existing methods of multiphoton fluorescence imaging to directly observe and quantify basic physiological parameters of the kidney including glomerular filtration rate (GFR) and permeability, blood flow, urinary concentration/dilution, renin content and release, as well as more integrated and complex functions like the tubuloglomerular feedback (TGF)-mediated oscillations in glomerular filtration and tubular flow. Streptozotocin-induced diabetes significantly increased single-nephron GFR (SNGFR) from 32.4 +/- 0.4 to 59.5 +/- 2.5 nl/min and glomerular permeability to a 70-kDa fluorophore approximately eightfold. The loop diuretic furosemide 2-fold diluted and increased approximately 10-fold the volume of distal tubular fluid, while also causing the release of 20% of juxtaglomerular renin content. Significantly higher speeds of individual red blood cells were measured in intraglomerular capillaries (16.7 +/- 0.4 mm/s) compared with peritubular vessels (4.7 +/- 0.2 mm/s). Regular periods of glomerular contraction-relaxation were observed, resulting in oscillations of filtration and tubular flow rate. Oscillations in proximal and distal tubular flow showed similar cycle times ( approximately 45 s) to glomerular filtration, with a delay of approximately 5-10 and 25-30 s, respectively. These innovative technologies provide the most complex, immediate, and dynamic portrayal of renal function, clearly depicting the components and mechanisms involved in normal physiology and pathophysiology.
Computer automated multi-paradigm modeling in control system design (2002)

The complete control system design effort involves many stages during which partial design tasks are completed. Each of those tasks requires different modeling paradigms and different tools. Furthermore, the designed embedded control system entails a wide variety of implementation technologies that all require different specification formalisms. To handle such a multitude of modeling paradigms and different support tools: 1) a unifying generic standard language can be applied; and 2) the required modeling paradigms can be modeled by a meta model using a shared meta language. An overview of the required parts and structure of a modeling environment and of the two approaches is given. The advantages with respect to multi-paradigm modeling are discussed.
Precoding in Multiantenna and Multiuser Communications (2004)

In this paper, Tomlinson-Harashima Precoding for multiple-input/multiple-output systems including multiple-antenna and multiuser systems is studied. It is shown that nonlinear preequalization offers significant advantages over linear preequalization which increases average transmit power. Moreover, it outperforms decision-feedback equalization at the receiver side which is applicable if joint processing at the receiver side is possible, and which suffers from error propagation. A number of aspects of practical importance are studied. Loading, i.e., the optimum distribution of transmit power and rate is discussed in detail. It is shown that the capacity of the underlying MIMO channel can be utilized asymptotically by means of nonlinear precoding.
Aromatic Borylation/Amidation/Oxidation:  A Rapid Route to 5-Substituted 3-Amidophenols (2006)

[reaction: see text] 5-Substituted 3-amidophenols are prepared by subjecting 3-substituted halobenzenes to an Ir-catalyzed aromatic borylation, followed by a Pd-catalyzed amidation, and finally an oxidation of the boronic ester intermediate. The entire C-H activation borylation/amidation/oxidation sequence can be accomplished without isolation of any intermediate arenes. Usefully, amide partners can include lactams, carbamates, and ureas.
IL‐10 induces DNA binding activity of three STAT proteins (Stat1, Stat3, and Stat5) and their distinct combinatorial assembly in the promoters of selected genes (1996)

Interaction of IL-10 with its receptor leads to the activation of STAT transcription factors. Herein we report the IL-10 dependent simultaneous activation of three STAT transcription factors: Stat1, Stat3, and Stat5. Upon IL-10 treatment multiple Stat proteins become simultaneously activated, and bind to different promoters with equal kinetics but form distinct homo- and heterodimeric transcriptionally active complexes depending on the STAT-consensus elements of a selected gene promoter. Upon IL-10 treatment Stat1, 3, and 5 bind to the GRR of the FcgammaRI gene, activated Stat1 and 3 bind to the SIE sequence of the c-fos promoter and transcriptionally active Stat5 assembles at the PRL-STAT consensus sequence of the beta-casein gene. Thus, functionally relevant STAT dimerization is influenced by the activated cytokine receptor as well as the specific STAT consensus sequence present in a specific gene promoter.
Qualitative and quantitative evaluation of glucosinolates in cruciferous plantsduring their life cycles (2004)

SUMMARY Glucosinolates produced by Brassica species were investigated in relation to biofumigation, a term used to describe the effects some allelochemicals, including glucosinolate derived products, may have on soil-borne pathogens or other herbivores. Four Brassica species of the U-triangle, namely B. nigra (L.) Koch, B. carinata Braun, B. juncea (L.) Czern. and B. rapa L. were compared with respect to their qualitative and quantitative glucosinolate profiles in roots, stems, leaves and reproductive organs. Plants were monitored at four different development stages and the total glucosinolate content as well as their dry matter production as an indication of their potential biomass under field conditions were determined. Glucosinolate levels of up to 120 imol g -1 DM were found in B. nigra and B. juncea, while B. rapa did not show values over 25 imol g -1 DM at any stage of the investigated plant life cycles. In the three species at the top of U-triangle, reproductive tissues showed the highest glucosinolate concentration when compared to the rest of the plant parts, while in B. rapa, the roots were the organs with the highest glucosinolate concentration. The glucosinolate profile of the different plant parts of the species studied changed during the growth cycle, showing that the trade-off between glucosinolate profile and biomass production should be optimized in order to maximize the biofumigation effect of a crop. However, further information on other allelochemicals and on the different types of glucosinolate derived products resulting from autolysis or myrosinase catalyzed hydrolysis of glucosinolates at different reaction conditions is needed for the appropriate description of the potential biofumigation effects of different crops.
Interferon-γ switches monocyte differentiation from dendritic cells to macrophages (2002)

Human monocytes differentiate into dendritic cells (DCs) or macrophages according to the nature of environmental signals. Monocytes stimulated with granulocyte-macrophage colony-stimulating factor (GM-CSF) plus interleukin 4 (IL-4) yield DCs. We tested here whether interferon-gamma (IFN-gamma), a potent activator of macrophages, may modulate monocyte differentiation. Addition of IFN-gamma to IL-4 plus GM-CSF-stimulated monocytes switches their differentiation from DCs to CD14(-)CD64(+) macrophages. IFN-gamma increases macrophage colony-stimulating factor (M-CSF) and IL-6 production by IL-4 plus GM-CSF-stimulated monocytes by acting at the transcriptional level and acts together with IL-4 to up-regulate M-CSF but not IL-6 production. IFN-gamma also increases M-CSF receptor internalization. Results from neutralizing experiments show that both M-CSF and IL-6 are involved in the ability of IFN-gamma to skew monocyte differentiation from DCs to macrophages. Finally, this effect of IFN-gamma is limited to early stages of differentiation. When added to immature DCs, IFN-gamma up-regulates IL-6 but not M-CSF production and does not convert them to macrophages, even in the presence of exogenous M-CSF. In conclusion, IFN-gamma shifts monocyte differentiation to macrophages rather than DCs through autocrine M-CSF and IL-6 production. These data show that IFN-gamma controls the differentiation of antigen-presenting cells and thereby reveals a new mechanism by which IFN-gamma orchestrates the outcome of specific immune responses.
Trophic factors from pancreatic islets in combined hepatocyte-islet allografts enhance hepatocellular survival. (1989)

The purpose of this study was to determine the effect of pancreatic islets on the survival of clusters of rat hepatocytes transplanted across a major histocompatibility barrier into an ectopic site. Aggregates of hepatocytes and pancreatic islets were obtained from Wistar-Furth rats by an automated method of collagenase digestion. Approximately 8000 Wistar-Furth hepatocyte clusters (100 to 300 micron diameter) were transplanted beneath the renal capsule of Lewis rats with or without the addition of 800 pancreatic islets. Recipients received subcutaneous injections of cyclosporine A (CsA): 30 mg/kg on days 0, 1, and 2, 10 mg/kg on days 3 to 7, and 10 mg/kg every other day for days 8 to 28. In the absence of CsA recipient treatment, all the allografts were rejected within 7 days. The combined hepatocyte-islet allografts in recipients treated with CsA showed maintenance of morphologic integrity of both hepatocytes and islet cells 1, 2, and 4 weeks after transplantation, whereas in the absence of pancreatic islets, the hepatocellular aggregates degenerated despite CsA treatment, leaving only a thin rim of hepatocytes immediately adjacent to the renal parenchyma. It can be concluded that in immunosuppressed recipients hepatocyte-islet renal subcapsular allografts survived despite the presence of an intact liver, which indicates a possible role of trophic factors released locally from the islets.
Is There Any Scientific Basis of &lt;italic&gt;Hawan&lt;/italic&gt; to be used in Epilepsy-Prevention/Cure? (2015)

Epilepsy is a neuropsychiatric disorder associated with religiosity and spirituality. Nasal drug delivery systems are the best for diseases related to brain. In older times RishiMuni, ancient scholars and physicians used to recommend Hawan for mental peace and well being. Gayatri Mantra also tells that sughandhim (aroma, fragrance) puushtivardhanam (gives rise to good health). Om triambkum yajamahe, sughandhim puushtivardhanam, urvarukmev vandhanaat, mrityu mokshay mamritaat! Hawan is a scientific experiment in which special herbs (Hawan Samagri) are offered in the fire of medicinal woods ignited in a specially designed fire pit called agnikuñda. Hawan seems to be designed by the ancient scholars to fight with the diseases of the brain. Our metadata analysis demonstrates that the components of Hawan are having a number of volatile oils that are specifically useful for epilepsy through one or the other mechanism of action. Due to high temperature of fire the vapors of these oils enter into the central nervous system through nasal route. The routine of performing Hawan might keep the threshold value of the therapeutic components in the body and help in preventing epilepsy. In the present manuscript authors have tried to highlight and integrate the modern and ancient concepts for treatment and prevention of epilepsy.
Induction of Interleukin-12 and Gamma Interferon Requires Tumor Necrosis Factor Alpha for Protective T1-Cell-Mediated Immunity to Pulmonary<i>Cryptococcus neoformans</i>Infection (2002)

The development of T1-cell-mediated immunity is required to clear a pulmonary Cryptococcus neoformans infection. The objective of these studies was to determine the mechanism by which tumor necrosis factor alpha (TNF-alpha) augments the development of pulmonary T1 immunity to C. neoformans infection. TNF-alpha expression was detected in lavage sample cells at days 2, 3, and 7 following C. neoformans infection. The numbers of CFU in the lung were not different between control and anti-TNF-alpha-treated mice at any time point examined during the afferent phase of the response (days 0 to 7). However, neutralization of TNF-alpha prevented the initiation of pulmonary clearance during the efferent phase of the response (day 14). Administration of anti-TNF-alpha monoclonal antibody (day 0) diminished the lung levels of TNF-alpha, interleukin-12 (IL-12), and gamma interferon (IFN-gamma) induced by C. neoformans at day 7 postinfection. Neutralization of TNF-alpha (day 0) also altered the IFN-gamma/IL-4 ratio in the lung-associated lymph nodes at day 7 following C. neoformans infection. Anti-TNF-alpha-treated mice developed a pulmonary eosinophilia at day 14 postinfection. Consistent with the pulmonary eosinophilia, anti-TNF-alpha-treated mice exhibited elevated serum immunoglobulin E and inhibition of the anticryptococcal delayed-type hypersensitivity response, indicating a shift toward a T2 response. Neutralization of IL-12 also prevented lung leukocyte production of IFN-gamma in response to the infection. These findings demonstrate that afferent-phase TNF-alpha production is essential for the induction of IL-12 and IFN-gamma and neutralization of early TNF-alpha results in a T2 shift of the T1/T2 balance of antifungal immunity.
Randomized, Placebo-Controlled, Double-Blind Clinical Trial of Sertraline in the Treatment of Depression Complicating Alzheimer’s Disease: Initial Results From the Depression in Alzheimer’s Disease Study (2000)

Sertraline is superior to placebo in reducing depression in patients with Alzheimer's disease who also suffer from major depression.
Case studies of chilled water storage (1993)

Centralized chilled water systems are commonly used to meet the air conditioning needs of colleges, universities, medical complexes, and other large campuses or district cooling facilities. Data from the Association of Higher Education Facilities Officers (APPA) indicate that over half its members operate central cooling plants. Various configurations are in use, including single and multiple central chilling plants serving single distribution systems, nonconnected miniature central systems, and combinations of one central and one or more satellite plants on a single distribution loop. Central plant chillers may be electric motor-driven centrifugal compressors, gas engine-driven centrifugal compressors, steam turbine-driven centrifugal compressors, heat-driven absorption chillers, or combinations of these types. The usual refrigerants are chlorofluorocarbons (CFCs); but alternatives such as HCFCs, HFCs, ammonia (NH[sub 3]), and absorption solutions may also be employed. Free cooling via cooling towers is sometimes used, directly or indirectly, during periods of relatively low ambient air temperatures. During any central plant capacity expansion, O and M, capital, and life cycle costs are among the major concerns, as are the increasingly critical issues of reliability, flexibility, safety, and the environment. Specifically, atmospheric ozone depletion and the CFC refrigerant issue are now impacting everyone involved in the air conditioning field. Anyonemore » selecting or planning for new chiller capacity is faced with choosing from such options as CFCs, HCFCs, HFCs, ammonia, and absorption refrigeration. These choices have unique and serious drawbacks. Because of this chilled water storage is now experiencing increased application.« less
View interpolation with structured depth from multiview video (2011)

In this paper, we propose a method for interpolating multiview imagery which uses structured depth maps and multiview video plus inter-view connection information to represent a three-dimensional (3D) scene. The structured depth map consists of an inter-view consistent principal depth map and auxiliary depth information. The structured depth maps address the inconsistencies among estimated depth maps which may degrade the quality of rendered virtual views. Generated from multiple depth observations, the structuring of the depth maps is based on tested and adaptively chosen inter-view connections. Further, the use of connection information on the multiview video minimizes distortion due to varying illumination in the interpolated virtual views. Our approach improves the quality of rendered virtual views by up to 4 dB when compared to the reference MPEG view synthesis software for emerging multimedia services like 3D television and free-viewpoint television. Our approach obtains first the structured depth maps and the corresponding connection information. Second, it exploits the inter-view connection information when interpolating virtual views.
Isolation of non‐cytopathic viruses implicated in the aetiology of nephritis and baby chick nephropathy and serologically related to avian nephritis virus (1990)

Three embryo-lethal agents were isolated from broiler chickens having either stunting syndrome or baby chick nephropathy. The agents replicated at low levels in chick kidney cells, but a cytopathic effect was not seen. Their presence was detected by embryo mortalities after yolk sac inoculations. All three agents caused nephritis and growth suppression when inoculated into 1-day-old chicks, and one agent caused increased incidence of baby chick nephropathy. This, and one other agent, were serologically closely related to avian nephritis virus G-4260. Picornavirus-like particles were present in the kidneys of infected birds. The histopathology of baby chick nephropathy was similar to, although more severe than, the nephritis seen in clinically normal birds. The strain of birds used to produce chick kidney cells influenced the ability of G-4260 to form a cytopathic effect and plaques. Strain of bird also influenced the lesions produced on chorio-allantoic membranes after inoculation of G-4260 and the above isolates.
Involvement of Molecular Oxygen in the Enzyme-Catalyzed NADH Oxidation and Ferric Leghemoglobin Reduction (1992)

Ferric leghemoglobin reductase (FLbR) from soybean (Glycine max [L.] Merr) nodules catalyzed oxidation of NADH, reduction of ferric leghemoglobin (Lb(+3)), and reduction of dichloroindophenol (diaphorase activity). None of these reactions was detectable when O(2) was removed from the reaction system, but all were restored upon readdition of O(2). In the absence of exogenous electron carriers and in the presence of O(2) and excess NADH, FLbR catalyzed NADH oxidation with the generation of H(2)O(2) functioning as an NADH oxidase. The possible involvement of peroxide-like intermediates in the FLbR-catalyzed reactions was analyzed by measuring the effects of peroxidase and catalase on FLbR activities; both enzymes at low concentrations (about 2 mug/mL) stimulated the FLbR-catalyzed NADH oxidation and Lb(+3) reduction. The formation of H(2)O(2) during the FLbR-catalyzed NADH oxidation was confirmed using a sensitive assay based on the fluorescence emitted by dichlorofluorescin upon reaction with H(2)O(2). The stoichiometry ratios between the FLbR-catalyzed NADH oxidation and Lb(+3) reduction were not constant but changed with time and with concentrations of NADH and O(2) in the reaction solution, indicating that the reactions were not directly coupled and electrons from NADH oxidation were transferred to Lb(+3) by reaction intermediates. A study of the affinity of FLbR for O(2) showed that the enzyme required at least micromolar levels of dissolved O(2) for optimal activities. A mechanism for the FLbR-catalyzed reactions is proposed by analogy with related oxidoreductase systems.
EDGAR: Extraction of Drugs, Genes And Relations from the Biomedical Literature (1999)

EDGAR (Extraction of Drugs, Genes and Relations) is a natural language processing system that extracts information about drugs and genes relevant to cancer from the biomedical literature. This automatically extracted information has remarkable potential to facilitate computational analysis in the molecular biology of cancer, and the technology is straightforwardly generalizable to many areas of biomedicine. This paper reports on the mechanisms for automatically generating such assertions and on a simple application, conceptual clustering of documents. The system uses a stochastic part of speech tagger, generates an underspecified syntactic parse and then uses semantic and pragmatic information to construct its assertions. The system builds on two important existing resources: the MEDLINE database of biomedical citations and abstracts and the Unified Medical Language System, which provides syntactic and semantic information about the terms found in biomedical abstracts.
Alcium Phosphate Cement: A New Saviour for Furcation Perforation ? - An In-Vitro Study (2006)

This study was conducted to evaluate the sealing ability of a new material, self-setting injectable calcium phosphate cements in furcation perforations and compare it with light cured glass-ionomer cements and Cavit. Fifty recently extracted maxillary and mandibular molars with non-fused well developed roots were collected and intentional perforations were made in the furcation area with a bur. The perforations were repaired with calcium phosphate cement, Resin modified glass ionomer cement and cavit. These specimens were then immersed in 2% methylene blue dye. After their removal, they were sectioned and examined under stereomicroscope to evaluate dye penetration. Results demonstrated that furcation perforation repaired with calcium phosphate cement showed least micro leakage. In conclusion, calcium phosphate cement demonstrated better results than the other groups.
Hopping transport in systems of finite thickness or length (2011)

Variable-range hopping transport along short one-dimensional wires and across the shortest dimension of thin three-dimensional films and narrow two-dimensional ribbons is studied theoretically. Geometric and transport characteristics of the hopping resistor network are shown to depend on temperature $T$ and the dimensionality of the system. In two and three dimensions, the usual Mott law applies at high $T$ where the correlation length of the network is smaller than the sample thickness. As $T$ decreases, the network breaks into sparse filamentary paths while the Mott law changes to a different $T$ dependence, which is derived using the percolation theory methods. In one dimension, deviations from the Mott law are known to exist at all temperatures because of rare fluctuations. The evolution of such fluctuations from highly resistive ``breaks'' at high $T$ to highly conducting ``shorts'' at low $T$ is elucidated.
DNA damage in Pakistani pesticide‐manufacturing workers assayed using the Comet assay (2006)

The production and use of chemical pesticides has increased in recent years. Although the increased use of pesticides may benefit agriculture, they are also the potential source of environmental pollution, and exposure to pesticides can have negative consequences for human health. In the present study, we have assessed DNA damage in blood leukocytes from 29 Pakistani pesticide-factory workers and 35 controls of similar age and smoking history. The workers were exposed to various mixtures of organophosphates, carbamates, and pyrethroids. DNA damage was measured with the single cell gel electrophoresis (SCGE) assay or Comet assay, using the mean comet tail length (microm) as the DNA damage metric. Exposed workers had significantly longer comet tail lengths than the controls (mean +/- SD 19.98 +/- 2.87 vs. 7.38 +/- 1.48, P < 0.001). Of the possible confounding factors, smokers had significantly longer mean comet tail lengths than nonsmokers and exsmokers for both the workers (21.48 +/- 2.58 vs.18.37 +/- 2.28, P < 0.001) and the controls (8.86 +/- 0.56 vs. 6.79 +/- 1.31, P < 0.001), while age had a minimal effect on DNA damage (P > 0.05 and P < 0.05 for workers and controls, respectively). The results of this study indicate that occupational exposure to pesticides causes DNA damage.