gebhart/patrepeval huggingface dataset:
Regulation of pim and myb mRNA accumulation by interleukin 2 and interleukin 3 in murine hematopoietic cell lines. (1988)

We have studied the mRNA accumulation of pim and myb genes in two interleukin 2- (IL2-)dependent, CTLL-2 and B6.1, and one IL3-dependent, FDC-P2, murine hematopoietic cell lines. To be able to dissociate the IL2 response from the phenomenon of lymphocyte activation, we used cell lines constitutively expressing the high affinity IL2 receptor. Deprivation of IL2 for 16 h led to an accumulation of CTLL-2 cells in G0/G1, and stimulation with IL2 induced a progression in S phase after 10 h. An increased accumulation of pim mRNA was observed in all cases in response to IL2 or IL3. This regulation did not require de novo protein synthesis and was, in CTLL-2 cells, mostly at the transcriptional level. Expression of myb was more complex: in CTLL-2 and FDC-P2 it is high and constitutive, while in B6.1 it is low and induced by IL2. This difference in myb regulation correlates with the higher level of myb expression in immature cells, as only B6.1 is functionally mature. Furthermore, it shows that transcription of myb does not affect the control of the cell cycle by the growth factors IL2 and IL3. These studies demonstrate that pim belongs to the small group of protooncogenes that can be induced during the primary response to growth factors (fos, myc, and myb) and that constitutive expression of myb, at least at the RNA level, is not sufficient to abrogate the growth factor requirement of hematopoietic cell lines.
A Framework for Integrated Services Over Shared and Switched IEEE 802 LAN Technologies (2000)

This memo describes a framework for supporting IETF Integrated Services on shared and switched LAN infrastructure. It includes background material on the capabilities of IEEE 802 like networks with regard to parameters that affect Integrated Services such as access latency, delay variation and queuing support in LAN switches. It discusses aspects of IETF's Integrated Services model that cannot easily be accommodated in different LAN environments. It outlines a functional model for supporting the Resource Reservation Protocol (RSVP) in such LAN environments. Details of extensions to RSVP for use over LANs are described in an accompanying memo [14]. Mappings of the various Integrated Services onto IEEE 802 LANs are described in another memo [13].
Multiple Authentication Exchanges in the Internet Key Exchange (IKEv2) Protocol (2006)

Internet community.It does not specify an Internet standard of any kind.Discussion and suggestions for improvement are requested.
Control method for mono inverter dual parallel interior permanent magnet synchronous machine drive system (2015)

This paper proposes the novel control method for mono inverter dual parallel (MIDP) interior permanent magnet synchronous machine (IPMSMs) drive system. It includes maximum torque per ampere (MTPA) control method to elevate drive efficiency and active damping control method to alleviate inherent stability problem of MIDP motor drive system. Due to the combination of reluctance and electromagnetic torques, the d- and q- axis currents of IPMSM are coupled unlike those of induction and surface mounted permanent magnet machines. For this reason, MTPA and active damping control of MIDP IPMSM drive system are far more complex than those with non-salient motors. In this paper, model based mathematical analysis about MTPA and active damping control for MIDP IPMSM drive system are provided. Experimental results with two 1.6kW IPMSMs are presented to verify the proposed algorithm.
Probing Receptor Binding Activity of Interleukin-8 Dimer Using a Disulfide Trap (2006)

Interleukin-8 (IL-8), a member of the chemokine superfamily, exists as both monomers and dimers, and mediates its function by binding to neutrophil CXCR1 and CXCR2 receptors that belong to the G protein-coupled receptor class. It is now well established that the monomer functions as a high-affinity ligand, but the binding affinity of the dimer remains controversial. The approximately 1000-fold difference between monomer-dimer equilibrium constant (microM) and receptor binding constant (nM) of IL-8 does not allow receptor-binding affinity measurements of the native IL-8 dimer. In this study, we overcame this roadblock by creating a "trapped" nondissociating dimer that contains a disulfide bond across the dimer interface at the 2-fold symmetry point. The NMR studies show that the structure of this trapped dimer is indistinguishable from the native dimer. The trapped dimer, compared to a trapped monomer, bound CXCR1 with approximately 70-fold and CXCR2 with approximately 20-fold lower affinities. Receptor binding involves two interactions, between the IL-8 N-loop and receptor N-domain residues, and between IL-8 N-terminal and receptor extracellular loop residues. In contrast to a trapped monomer that bound an isolated CXCR1 N-domain peptide with microM affinity, the trapped dimer failed to show any binding, indicating that dimerization predominantly perturbs the binding of only the N-loop residues. These results demonstrate that only the monomer is a high-affinity ligand for both receptors, and also provide a structural basis for the lower binding affinity of the dimer.
In vivo evaluation of a novel porous hydroxyapatite to sustain osteogenesis of transplanted bone marrow-derived osteoblastic cells (2001)

Biosynthetic bone grafts are considered to contain one or more of three critical components: osteoprogenitor cells, an osteoconductive matrix, and osteoinductive growth factors. The basic requirements of the scaffold material are biocompatibility, mechanical integrity, and osteoconductivity. A major design problem is satisfying these requirements with a single composite. In this study, we hypothesize that one composite that combines bone marrow-derived osteoblasts and a novel mechanical reinforced porous hydroxyapatite with good biocompatibility and osteoconductivity (HA/BMO) can reach these requirements. A novel sintered porous hydroxyapatite (HA) was prepared by the following procedures. The HA slurry was foamed by adding polyoxyethylenelaurylether (PEI) and mixing. The pores were fixed by crosslinking PEI with diepoxy compounds and the HA porous body was sintered at 1200 degrees C for 3 h. The HA sintered porous body had a high porosity (77%), and was completely interconnected. Average pore diameter was 500 microm and the interconnecting path 200 microm in diameter. The compressive (17 MPa) and three-point bending (7 MPa) strengths were high. For in vivo testing, the 2-week subcultured HA/BMO (+) composites were implanted into subcutaneous sites of syngeneic rats until 8 weeks after implantation. These implants were harvested at different time points and prepared for the biochemical analysis of alkaline phosphatase activity (ALP) and bone osteocalcin content (OCN), and histological analysis. ALP and OCN in the HA/BMO group were much higher than those in the HA without BMOs control group 1 week after implantation (p < 0.001). Light microscopy revealed mature bone formation in the HA/BMO composite 4 weeks after implantation. In the SEM study, mineralized collagenous extracellular matrix was noted in HA/BMO composite 2 weeks after implantation with numbers of active osteoblasts. We conclude that the composite of the novel HA and cultured BMOs has osteogenic ability in vivo. These results provide a basis for further studies on the use of this composite as an implant in orthopaedic surgery.
IPv4-Embedded IPv6 Multicast Address Format (2011)

This document specifies an extension to the IPv6 multicast addressing
architecture to be used in the context of IPv4-IPv6 interconnection.
In particular, this document defines an address format for IPv4-
embedded IPv6 multicast addresses. This address format can be used for
IPv4-IPv6 translation or encapsulation schemes.
[Performance of an innovative polyethylene carrier biotrickling filter treating hydrogen sulphide gas]. (2010)

Characteristics of double-layer biotrickling filter using high density polythene rasching rings carrier treating waste gas containing hydrogen sulphide was studied. Results showed that biotrickling filter had significant advantages of low pressure drop and even load distribution along the reactor height. When removal efficiency was greater than 90%, gas retention time was 12 s, maximum inlet load was 110 g/(m3 x h), elimination capacity was 84 g/(m3 x h). At steady state, about 37%-55% of hydrogen sulfide load was removed from the lower layer. During long-term operation, pressure drop kept to less than 280 Pa x m(-1), the backwashing period was longer than two months, no biomass accumulation happened in the lower layer, and abnormal increase in pressure drop can be used as a indicator of backwashing. Reactor recovery and restart experimental results showed that removal efficiency recovered to 95% in 1 day after 6 days without H2S, pH dramatic variation of spray liquid had significant adverse impact on biotrickling bed reactor.
High-speed compressed sensing measurement using spectrally-encoded ultrafast laser pulses (2015)

We present a chirp processing technique for encoding pseudorandom patterns onto the spectra of broadband optical pulses for compressed sensing (CS) measurement. We demonstrate applications to characterization of ultrawideband sparse radio frequency (RF) signals and to very high-speed continuous microscopic flow imaging. In both domains, the optical sampling technique permits accurate recovery of the signals under test from only a few percent of the measurements required for conventional Nyquist sampling, significantly relaxing the required analog-to-digital conversion bandwidth and amount of data storage.
Amino group enhanced phenazine derivatives as electrode materials for lithium storage (2017)

The development of organic molecule-based batteries is hampered by stability issues caused by the dissolution of the active organic materials in electrolytes. Herein, phenazine (PNZ) and 2,3-diaminophenazine (DAP) are investigated as organic electrode materials. The presence of amino functional groups in DAP dramatically enhances its electrochemical performances due to suppressed dissolution in the electrolyte.
An Energy Scalable Computational Array for Sensor Signal Processing (2006)

Harvesting energy from environmental sources can extend wireless sensor network node lifetime beyond the limits of battery technology. However, the output power from an energy harvester is highly variable. We propose a domain-specific computational array which maximizes sensor performance by matching system power consumption to the available scavenged energy through power scalable approximate signal processing. The array consists of distributed arithmetic (DA) based functional units coupled with a reconfigurable interconnect structure. Each unit implements several core linear and nonlinear signal processing functions in an area efficient manner which also minimizes leakage power. Several sensor DSP applications (FIR, IIR, and FFT) have been mapped onto the array. Post-layout simulations confirm that the proposed domain-specific computational array is energy efficient and energy scalable
Towards a true spherical camera (2009)

We present the design of a spherical imaging system with the following properties: (i) A 4π field of view that enables it to "see" in all directions; (ii) a single center of projection to avoid parallax within the field of view; and (iii) a uniform spatial and angular resolution in order to achieve a uniform sampling of the field of view. Our design consists of a spherical (ball) lens encased within a spherical detector shell. The detector shell has a uniform distribution of sensing elements, but with free space between neighboring elements, thereby making the detector partly transparent to light. We determine the optimal dimensions of the sensing elements and the diameter of the detector shell that produce the most compact point spread function. The image captured with such a camera has minimal blur and can be deblurred using spherical deconvolution. Current solid state technologies do not permit the fabrication of a high resolution spherical detector array. Therefore, in order to verify our design, we have built a prototype spherical camera with a single sensing element, which can scan a spherical image one pixel at a time.
Oligo-2,6-naphthylenevinylenes – New Building Blocks for the Preparation of Photoluminescent Polymeric Materials (1999)

Synthetic strategies towards appropriate symmetric and unsymmetric functionalization of the naphthalene ring are presented. By means of Knoevenagel and Wittig condensation reactions new fluorescent, differently functionalized oligo(2,6-naphthylenevinylene)s have been synthesized, the presence of terminal aldehyde or bromine substitution opening the way to the incorporation of the fluorescent trimers in a variety of polymeric materials. The effect of substituting the phenylene ring by the more bulky dialkoxynaphthalene system in arylenevinylene-type materials is studied from the structural point of view and the possibility to tune the emission color and the electron affinity through the introduction of naphthylenevinylene and cyano-substituted naphthylenevinylene units is also investigated.
CAVITY RING DOWN SPECTROSCOPY WITH CW DIODE LASER EXCITATION (1995)

Author Institution: Princeton University, Princeton, NJ 08544
Critical Chain Project Management: Motivation &#x00026; overview (2010)

This paper provides an overview of the aspects of Critical Chain that make it successful, and then provides an introduction to Critical Chain and its application. Project Management involves making and keeping commitments under uncertainty, accompanied by complexity and interdependency. In most project management environments, making binding commitments is expected in three separate dimensions: 1) schedule or time, 2) resource or budget, and 3) scope, quality, or performance objectives. Falling short of a commitment can result in the project being deemed a failure, with attendant negative consequences to stakeholders. Evidence suggests a high rate of Project Management failure exists industry-wide. Searching for solutions to the problem of high project failure rates yields many valuable contributions. However, a need remains of finding an approach to project management that is effective across diverse domains, and that can be taught to, and successfully applied by, the majority of project managers of average abilities and experience. A technique called Critical Chain has potential in this regard and is backed by over a decade of field testing and refinement. Critical Chain takes a different approach to handling risk versus most traditional methods of project management such as critical path project management. Traditionally the risk associated with a task is handled by the duration estimate of the individual task. Due to the Student Syndrome and Parkinson's Law this method has not proven to have the desired effect. By utilizing a pooled or aggregated risk methodology, task durations can be shortened to the task's average time to completion, and the variability of the tasks in actuality can be planned for and handled via buffers placed in locations that protect the project as a whole. The buffers utilize the safety time removed from individual tasks. However, it has been found that using more aggressive task durations in conjunction with the buffers results in shorter overall project durations and better on-time performance.
Phenotypic heterogeneity of primitive leukemic hematopoietic cells in patients with chronic myeloid leukemia (1992)

The peripheral blood of chronic myeloid leukemia (CML) patients with chronic-phase disease and elevated white blood cell (WBC) counts typically contains markedly increased numbers of a variety of neoplastic pluripotent and lineage-restricted hematopoietic progenitors. These include cells detected in standard colony assays as well as their more primitive precursors. The latter are referred to as long-term culture-initiating cells (LTC-IC) because of their ability to generate clonogenic cell progeny detectable after a minimum of 5 weeks incubation on competent fibroblast feeder layers. In this study, we have investigated a number of the properties of the LTC-IC and clonogenic cells present in the blood of such CML patients with high WBC counts. This included an analysis of the light scattering properties of these progenitors, as well as their expression of CD34 and HLA-DR, Rhodamine-123 staining, and in vitro sensitivity to 4- hydroperoxycyclophosphamide. In the case of LTC-IC, the production of different types of lineage-restricted and multipotent progeny was also analyzed. Most of the circulating LTC-IC and clonogenic cells in the CML patients studied (on average approximately 70% and approximately 90%, respectively) showed features of proliferating or activated cells. This is in marked contrast to the majority of progenitors in the blood of normal individuals and most of the LTC-IC in normal marrow, all of which exhibit a phenotype expected of quiescent cells. Interestingly, a significant proportion of the circulating clonogenic cells and LTC-IC in the CML samples studied (on average approximately 10% and approximately 30%, respectively) appeared to be phenotypically similar to normal circulating progenitors, although their absolute numbers were indicative of a neoplastic origin. Both phenotypes of circulating CML clonogenic cells and LTC-IC could be obtained at approximately 10% to 20% purity by differential multiparameter sorting. These findings suggest that expansion of the Philadelphia chromosome-positive clone at the level of the earliest types of hematopoietic cells results from the activation of mechanisms that enable some, but not all, signals that block the cycling of normal stem cells to be bypassed or overcome. In addition, they provide strategies for purifying these primitive leukemic cells that should facilitate further analysis of the mechanisms underlying their abnormal proliferative behavior.
Reinforcement of recycled PET for mechanical properties of isotactic polypropylene (2019)

For high-value use of recycled polyethylene terephthalate (r-PET) resource and simultaneous development of high performance isotactic polypropylene (PP) materials, the blends of r-PET with PP and its compatibilized versions were prepared. PP-g-MA, POE-g-MA and EVA-g-MA with same functional group, as well as their mixtures, were used as compatibilizer. The crystallization behavior, mechanical properties and microphotographs of r-PET/compatibilizer, r-PET/PP bleds and its compatibilized versions were characterized. The results indicated that addition of compatibilizer decreased the tensile and flexural strength of r-PET and slightly improve its impact strength. The introduction of r-PET to PP matrix increased the tensile and flexural strength of PP. The tensile and flexural strength of compatibilized r-PET/PP are dependent on the kinds of compatibilizers. Addition of PP-g-MA improved the tensile and flexural strength of r-PET/PP blends and introduction of POE-g-MA or EVA-g-MA increased the impact strength of r-PET/PP blends. Effect of compatibilizer and its mixtures and r-PET content on the mechanical properties of compatibilized r-PET/PP blends is discussed. The r-PET/PP blends with high strength and toughness can be obtained by compatibilization of the mixtures of PP-g-MA and POE-g-MA (or EVA-g-MA). This investigation provides an effective method to use the r-PET to prepare high performance PP blends with low cost and high-value. Keywords: Recycled PET, Polypropylene, Mechanical properties
Polyploid organisms (2012)

Polyploids are organisms with three or more complete chromosome sets. Polyploidization is widespread in plants and animals, and is an important mechanism of speciation. Genome sequencing and related molecular systematics and bioinformatics studies on plants and animals in recent years support the view that species have been shaped by whole genome duplication during evolution. The stability of polyploids depends on rapid genome recombination and changes in gene expression after formation. The formation of polyploids and subsequent diploidization are important aspects in long-term evolution. Polyploids can be formed in various ways. Among them, hybrid organisms formed by distant hybridization could produce unreduced gametes and thus generate offspring with doubled chromosomes, which is a fast, efficient method of polyploidization. The formation of fertile polyploids not only promoted the interflow of genetic materials among species and enriched the species diversity, but also laid the foundation for polyploidy breeding. The study of polyploids has both important theoretical significance and valuable applications. The production and application of polyploidy breeding have brought remarkable economic and social benefits.
Determination of Pesticides in Apple-Based Infant Foods Using Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry (2005)

A liquid chromatography electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS) method was developed and validated to quantify and confirm trace levels of 13 pesticides including aldicarb sulfoxide, aldicarb sulfone, oxamyl, methomyl, formetanate, 3-hydroxycarbofuran, carbendazim, thiabendazole, aldicarb, propoxur, carbofuran, carbaryl, and methiocarb in apple-based infant foods such as apple sauces, apples and strawberries, apples and blueberries, and apples and plums. Data acquisition under MS/MS was achieved by applying multiple reaction monitoring of two fragment ion transitions to provide a high degree of sensitivity and selectivity for both quantification and confirmation. LC/ESI-MS/MS quantitative results were significantly affected by matrices, and thus, the standard addition was employed to compensate for the matrix effects to achieve the best accuracy of the method. Recoveries of 13 pesticides, spiked at 5.0, 25.0, and 45.0 microg/kg, were around 100% using the LC/ESI-MS/MS standard addition. The method detection limits (S/N > or = 3:1) of 13 pesticides were less than 0.2 microg/kg.
Sustainable Energy Systems: A New Paradigm for New Energy Technologies (1991)

The fundamental links between energy production/use and the environment are becoming increasingly apparent. The major environmental challenges of global climate change, acid precipitation, urban air pollution, stratospheric ozone depletion and solid waste are all consequences of the way our society produces and uses energy. This paper defines sustainability and discusses some of its key concepts such as the recycling of materials and nutrients, full accounting of all external costs, the steady state (instead of growth) economy and the proper indices for economic/ecological health (instead of G.N.P.). The paper will also address some of the program initiatives of the Pennsylvania Energy Office to encourage the transition towards sustainable energy systems.
Age influences chemotherapy response in astrocytomas (1995)

Age is strongly predictive of the likelihood of a response to chemotherapy, time to progression, survival, and risk of myelosuppressive complications. Patients aged > or = 60 have a lower change of benefit and an increased risk of myelosuppressive complications from chemotherapy for astrocytomas compared with younger patients.
The Inhibitory Effect of Resveratrol on Elastin Amyloidogenesis (2014)

The role of polyphenols in the prevention of degenerative diseases is emerging in the last years. In this report, we will investigate in vitro the inhibitory effect of resveratrol on elastin amyloidogenesis. The effect of resveratrol on molecular structure was investigated by circular dichroism spectroscopy, while the inhibitory effect on self-assembly was evaluated by turbidimetry as a function of temperature and by atomic force microscopy.