gebhart/patrepeval huggingface dataset:
p300 and estrogen receptor cooperatively activate transcription via differential enhancement of initiation and reinitiation (1998)

Estrogen- and antiestrogen-regulated, AF-2-dependent transcriptional activation by purified full-length human estrogen receptor (ER) was carried out with chromatin templates in vitro. With this system, the ability of purified human p300 to function as a transcriptional coactivator was examined. In the absence of ligand-activated ER, p300 was found to have little effect (less than twofold increase) on transcription, whereas, in contrast, p300 was observed to act synergistically with ligand-activated ER to enhance transcription. When transcription was limited to a single round, p300 and ER were found to enhance the efficiency of transcription initiation in a cooperative manner. On the other hand, when transcription reinitiation was allowed to occur, ER, but not p300, was able to increase the number of rounds of transcription. These results suggest a two-stroke mechanism for transcriptional activation by ligand-activated ER and p300. In the first stroke, ER and p300 function cooperatively to increase the efficiency of productive transcription initiation. In the second stroke, ER promotes the reassembly of the transcription preinitiation complex. Therefore, ER exhibits distinct, dual functions in transcription initiation and reinitiation.
Towards workload shift detection and prediction for autonomic databases (2007)

Due to the complexity of industry-scale database systems, the total cost of ownership for these systems is no longer dominated by hardware and software, but by administration expenses. Autonomic databases intend to reduce these costs by providing self-management features. Existing approaches towards this goal are supportive advisors for the database administrator and feedback control loops for online monitoring, analysis and re-configuration. But while advisors are too resource-consuming for continuous operation, feedback control loops suffer from overreaction, oscillation and interference.
UV observations of x ray binaries (1990)

IUE (International Ultraviolet Explorer) has observed both high and low mass x ray binaries throughout its life. The UV spectra of high mass systems reveal the nature of the massive companion star and the effects of the x ray illumination of the stellar wind. In loss mass systems, the x ray illuminated disk or companion star dominates the UV light. System parameters and the characteristics of the accretion disk can be inferred.
Development of an Automated, Quasi-Continuous Method for the Simultaneous Determination of Nitrogen Oxides, Aldehydes, and Ketones in Air (1994)

Abstract The development of an automated method for the simultaneous determination of nitrogen oxides, aldehydes and ketones is described. All components are sampled together by means of impingers, which are filled with an acidified solution of DNPH in acetonitrile. The corresponding derivatives are separated and quantified by reversed-phase HPLC with UV detection at 300 nm or at 345 nm. Using this reproducible method calibration curves with a correlation coefficient of 0.999 could be obtained. The method was validated by means of several field tests, measuring candle smoke and cigarette smoke.
Síndrome de Burnout en odontólogos de la XVIII Región Sanitaria del Ministerio de Salud Pública y Bienestar Social, Paraguay (2017)

El Sindrome de Burnout (SB) es la disfuncion psicologica que aparece como consecuencia a una respuesta inadecuada al estres laboral cronico.
A comparison of the effects of the hypocholesteremic agents, cholestyramine and candicidin, on the induction of intestinal tumors in rats by azoxymethane. (1977)

Summary The effects of the ingestion of cholestyramine (2% in Purina rat chow) and candicidin (0.04%) on intestinal carcinogenesis by azoxymethane was studied in male Sprague-Dawley rats. Groups of 20 animals were given 8 mg of azoxymethane per kg per week for 25 weeks when the study was terminated. Although each drug affects lipid metabolism differently, they increased the number of intestinal tumors over those of controls to the same degree, from an average of 5 to 7.5 tumors per rat. There were no tumors in animals not injected with azoxymethane. The cholestyramine-treated group of rats developed significantly more tumors in the large intestine than did the other groups, whereas candicidin-fed rats had the greatest number of tumors in the distal small intestine. The feces of the cholestyramine-fed animals contained more total bile acids and a greater percentage of secondary bile acids than in normal animals. In the candicidin-treated group, the feces had increased amounts of cholesterol and its metabolites and also a greater degree of cholesterol degradation. These results suggest that bile acids have a greater promoting effect on tumorigenesis in the large intestine, whereas the effect of cholesterol and/or its degradation products is greater in the distal small intestine. These findings support the concept that the carcinogenic process may vary in the different segments of the intestinal tract.
An Introduction to Critical Cartography (2015)

This paper provides a brief introduction to critical cartography. We define critical cartography as a one-two punch of new mapping practices and theoretical critique. Critical cartography challenges academic cartography by linking geographic knowledge with power, and thus is political. Although contemporary critical cartography rose to prominence in the 1990s, we argue that it can only be understood in the historical context of the development of the cartographic discipline more generally. We sketch some of the history of this development, and show that critiques have continually accompanied the discipline. In the post-war period cartography underwent a significant solidification as a science, while at the same time other mapping practices (particularly artistic experimentation with spatial representation) were occurring. Coupled with the resurgence of theoretical critiques during the 1990s, these developments serve to question the relevance of the discipline of cartography at a time when mapping is increasingly prevalent and vital.
Accelerated Epidermal Regeneration and Improved Dermal Reconstruction Achieved by Polyethersulfone Nanofibers (2010)

The characterization of nanofibers showed that the PES membrane has nanoscale, porous, high surface area structure. These properties conferred higher exudate absorption capacity for the PES scaffold which is essential for effective wound healing. In vitro results indicated that the PES scaffold can support fibroblast proliferation similar to that with tissue culture polystyrene. Epithelial regeneration was expeditiously accelerated under PES as compared with Vaseline gauze. Greater fibroblast maturation, improved collagen deposition and faster edema resolution were the superior properties of PES over the commercial dressing. Based on these results we conclude that the biocompatible PES nanofibers can effectively be used as a dressing to accelerate wound healing.
Survey of Large-Scale MIMO Systems (2015)

The escalating teletraffic growth imposed by the proliferation of smartphones and tablet computers outstrips the capacity increase of wireless communications networks. Furthermore, it results in substantially increased carbon dioxide emissions. As a powerful countermeasure, in the case of full-rank channel matrices, MIMO techniques are potentially capable of linearly increasing the capacity or decreasing the transmit power upon commensurately increasing the number of antennas. Hence, the recent concept of large-scale MIMO (LS-MIMO) systems has attracted substantial research attention and been regarded as a promising technique for next-generation wireless communications networks. Therefore, this paper surveys the state of the art of LS-MIMO systems. First, we discuss the measurement and modeling of LS-MIMO channels. Then, some typical application scenarios are classified and analyzed. Key techniques of both the physical and network layers are also detailed. Finally, we conclude with a range of challenges and future research topics.
Synthesis of new type pesticide Oxamyl (2006)

Objective: To study synthesis of the new type pesticide Oxamyl.Methods: The two methods of non-solvent process and solvent process were adopted to prepare oxamyl.Oxamyl was prepared in water in the first one and in acetone in the second.By the comparisons of productive cost,production purity,operation safety and equipment cost,a proper process for preparation oxamyl was adopted.Results: The non-solvent process was better.The materials ratio was n(oxamyl oxime)∶n(methyl isocyanate)=1∶1.2.Methyl isocyanate was slowly added dropwise to oxamyl oxime in water at about 30 ℃.After being crystallized,filtered and dried,oxamyl could be obtained with purity≥99%(HPLC),m.p.98～101 ℃,yield≥95%(base on oxamyl oxime).Conclusion: The non-solvent process of the preparation for oxamyl is suitable for mass production due to its low production cost,high purity,no methyl isocyante remains,easy operation and lower equipment cost.
Use of Gravity Gradiometry in Precision Inertial Navigation Systems (2011)

Gravity gradiometry can be employed to reduce the gravity modeling error in high precision inertial navigation systems (INSs) in free-inertial navigation. e beneĕt of a gravity gradient instrument is that the measurement is completely passive and not subject to interference from external sources, and gravity formulae or tables will no longer be needed to obtain the INS solution. In line with the inertial navigation paradigm, as long the initial gravity vector is known, the local acceleration of gravity g(x, z) can be estimated autonomously and accurately on the Ęy using onboard accelerometer measurements, provided that the acceleration measurements are very accurate, as is the case in cold atom interferometry-based instruments. e beneĕt of combining measurements from multiple INSs is also addressed, and a free-inertial aircra navigation scenario is presented.
Characterization of Cord-Blood-Derived Human Mast Cells Cultured in the Presence of Steel Factor and lnterleukin-6 (1995)

We generated > 10(7) mast cells by culturing 10(7) cord blood mononuclear cells for > 10 weeks in the presence of Steel factor, interleukin-6 and prostaglandin E2. 99% of the cultured cells had tryptase-positive granules, while 18% had chymase-positive granules. Cultured mast cells contained 3.6 micrograms histamine and 3.5 micrograms tryptase per 10(6) cells. Cells sensitized with 1 microgram/ml human IgE released 58.5% histamine and 1.55 ng tumor necrosis factor (TNF)-alpha per 10(6) cells when challenged with 1 microgram/ml antihuman IgE, whereas the control cells spontaneously released 3.7% histamine and 0.18 ng TNF-alpha. Analysis for surface antigens revealed that cultured mast cells expressed the following CD molecules: 9, 13, 14, 29, 33, 38, 43, 44, 45RA, 45RB, 46, 47, 48, 49d, 50, 51, 53, 54, 55, 58, 59, 60, 61 and 117 (c-Kit). Taken together, these cultured cells seem to be functionally mature mast cells.
High throughput detection of helminth eggs using mobile phone microscopy (2015)

Traditional screening techniques and mass screening model of soil-transmitted helminths pose certain challenges to the eradication of infection within a population. The sereening technique proposed in Ihis paper overcomes these challenges by offering high throughput screening allow costs.
Scintillation Properties of and Self Absorption in ${\rm SrI}_{2}\!:\!{\rm Eu}^{2+}$ (2011)

The scintillation properties of pure SrI <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> and SrI <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> doped with 0.5%, 0.86%, 2%, and 5% europium were studied. Different techniques were used to measure γ-ray excited pulse-height and scintillation decay time spectra, and to perform X-ray excited and optically excited emission spectroscopy. Eu <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2+</sup> emission and trapped exciton (TE) emission was observed in SrI <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> :Eu <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2+</sup> samples. These emissions were studied as a function of temperature, Eu concentration, and sample size. A spectral overlap was observed between Eu <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2+</sup> excitation and emission spectra, the amount of overlap depends on temperature. The light yield, energy resolution and luminescence decay profiles reveal also a dependence on temperature, sample size, and Eu concentration. The observations were analyzed and interpreted in terms of two separate models. One model consists of the relation between TE and Eu <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2+</sup> emission and the other deals with self absorption processes.
Transplantation of Cultured Thymic Fragments: Results in Nude Mice (1984)

Transplantation of F344 rat cultured thymic fragments was able to restore immune function to nude mice. Approximately half of such animals displayed increased lifespan (7-8 months). These mice were also capable of rejecting allogeneic mouse skin and rat skin from a strain (Buffalo) unrelated to the thymus donor; however, they were incapable of rejecting rat skin from the thymus donor strain. Proliferative responses to T-cell mitogens were restored. Proliferative responses to alloantigens and xenoantigens in mixed leucocyte cultures were also restored and showed the same patterns of specific reactivity and non-reactivity as in skin graft rejection. The ability to make antibody responses to specific antigens was also restored, but the responsiveness was more variable than for cell-mediated responses. Some mice were able to make antibody to rabbit serum proteins; however, fewer mice made antibody to ovalbumin. The inability to respond to ovalbumin may be due to the fact that F344 rats are low responders to this protein. These results suggest that cultured xenogeneic thymus is effective in restoring two major differentiation functions of the normal thymus gland: development of specific antigen responsiveness and non-responsiveness.
Dialectical Contradictions Experienced When Placing a Spouse With Dementia in a Residential Care Facility (2010)

Placing a spouse with dementia in a care facility can be a devastating decision, and the placement process can be disruptive and difficult for all involved. This case study explores dialectical contradictions experienced during the placement decision-making process, on the day of placement, and in the weeks following placement. Ways in which findings could be applied to support spouses at this difficult time are also discussed.
Bcl2-L-10, a novel anti-apoptotic member of the Bcl-2 family, blocks apoptosis in the mitochondria death pathway but not in the death receptor pathway (2001)

By GenBank database searches and PCR, we have identified a novel human Bcl2-like gene, Bcl2-L-10, which contains conserved BH4, BH1 and BH2 domains but lacks BH3 domain. The Bcl2-L-10 gene has been assigned to chromosome 15q21.2. Transfection experiments demonstrated that Bcl2-L-10 can block apoptosis induced by interleukin-3 withdrawal and Bax expression, by prevention of cytochrome C release, caspase-3 activation and mitochondrial membrane potential collapse. Bcl2-L-10 cannot block TNFalpha-induced apoptosis. Furthermore, both the BH4 domain and the transmembrane domain of Bcl2-L-10 are necessary for its suppressive action on cell death. Our results demonstrated that Bcl2-L-10 is a newly detected anti-apoptotic member of the Bcl-2 family and that it blocks apoptosis in the mitochondrial death pathway but not in the death receptor pathway.
The Asn-420-linked Sugar Chain in Human Epidermal Growth Factor Receptor Suppresses Ligand-independent Spontaneous Oligomerization (2000)

To elucidate a role(s) of Asn-linked sugar chain(s) in the function of epidermal growth factor receptor (EGFR), a series of the EGFR mutants were prepared in which potential glycosylation sites in the domain III were eliminated by site-directed mutagenesis. Although the wild-type and mutants of Asn-328, Asn-337, and Asn-389 underwent autophosphorylation in response to epidermal growth factor (EGF), the Asn-420 --> Gln mutant was found to be constitutively tyrosine-phosphorylated. This abnormal ligand-independent phosphorylation of the mutant appears to be due to a ligand-independent spontaneous oligomer formation, as shown by a cross-linking experiment using the purified soluble extracellular domain (sEGFR). As revealed by the dissociation of the Asn-420 --> Gln sEGFR oligomer by simple dilution, it seems likely that the equilibrium is shifted toward oligomer formation to an unusual degree. Furthermore, it was also found that the mutation caused a loss of the ability to bind EGF. These findings suggest that the sugar chain linked to Asn-420 plays a crucial role in EGF binding and prevents spontaneous oligomerization of the EGFR, which may otherwise lead to uncontrollable receptor activation, and support the view of a specific role of an Asn-linked sugar chain in the function of a glycoprotein.
Cultural Values in Magazine Advertising: A Comparative Study of the Arab World and the United States (2019)

The current research examined differences and similarities in content and appeal of magazine advertisements in the Arab world and the United States. The motivation behind this research resides in the fact that the Arab culture is going through increasing change that affects consumers’ perception and behavior (Kalliny & Gentry, 2007). The change may create confusion and ambiguity in the international marketing environment of this region. This raises two main research concerns: first, previous research findings will have to go through a rigorous review to account for the changes that are sweeping the Arab region. Second, future research must capture those changes and assess their impact on the Arab society and culture. Therefore, the purpose of this paper is to examine the current cultural values used in magazine advertisements in the Arab region and compare them to those used in magazine advertisements in the United States. The results of this study should be interpreted with caution due to the limitation of the sample and the dependency on coders’ accuracy. Future research should focus on expanding the sample and investigate these cultural values in other advertising medium such as digital and TV advertisements.
Smoking and Pain (2010)

Cigarette smoke, which serves as a nicotine delivery vehicle in humans, produces profound changes in physiology. Experimental studies suggest that nicotine has analgesic properties. However, epidemiologic evidence shows that smoking is a risk factor for chronic pain. The complex relationship between smoking and pain not only is of scientific interest, but also has clinical relevance in the practice of anesthesiology and pain medicine. This review will examine current knowledge regarding how acute and chronic exposure to nicotine and cigarette smoke affects acute and chronic painful conditions. It will cover the relevant pharmacology of nicotine and other ligands at the nicotinic acetylcholine receptor as related to pain, explore the association of cigarette smoking with chronic painful conditions and potential mechanisms to explain this association, and examine clinical implications for the care of smokers with pain.
A Brush Seals Program Modeling and Developments (1996)

Some events of a U.S. Army/NASA Lewis Research Center brush seals program are reviewed, and the development of ceramic brush seals is described. Some preliminary room-temperature flow data are modeled and compare favorably to the results of Ergun.
Negative thermal expansion materials: technological key for control of thermal expansion (2012)

Most materials expand upon heating. However, although rare, some materials contract upon heating. Such negative thermal expansion (NTE) materials have enormous industrial merit because they can control the thermal expansion of materials. Recent progress in materials research enables us to obtain materials exhibiting negative coefficients of linear thermal expansion over -30 ppm K<sup>-1</sup>. Such giant NTE is opening a new phase of control of thermal expansion in composites. Specifically examining practical aspects, this review briefly summarizes materials and mechanisms of NTE as well as composites containing NTE materials, based mainly on activities of the last decade.
Action of Chondroitinase ABC on Epidurally Transplanted Nucleus Pulposus in the Rabbit (1999)

Chondroitinase ABC can enhance resolution of the nucleus pulposus in the epidural space.
Bacterial community structures of phosphate-removing and non-phosphate-removing activated sludges from sequencing batch reactors (1995)

The bacterial community structures of phosphate- and non-phosphate-removing activated sludges were compared. Sludge samples were obtained from two sequencing batch reactors (SBRs), and 16S rDNA clone libraries of the bacterial sludge populations were established. Community structures were determined by phylogenetic analyses of 97 and 92 partial clone sequences from SBR1 (phosphate-removing sludge) and SBR2 (non-phosphate-removing sludge), respectively. For both sludges, the predominant bacterial group with which clones were affiliated was the beta subclass of the proteobacteria. Other major groups represented were the alpha proteobacterial subclass, planctomycete group, and Flexibacter-Cytophaga-Bacteroides group. In addition, several clone groups unaffiliated with known bacterial assemblages were identified in the clone libraries. Acinetobacter spp., thought to be important in phosphate removal in activated sludge, were poorly represented by clone sequences in both libraries. Differences in community structure were observed between the phosphate- and non-phosphate-removing sludges; in particular, the Rhodocyclus group within the beta subclass was represented to a greater extent in the phosphate-removing community. Such differences may account for the differing phosphate-removing capabilities of the two activated sludge communities.
Recent advances in colonoscopy (2016)

Colonoscopy is an important and frequently performed procedure. It is effective in the prevention of colorectal cancer and is an important test in the investigation of many gastrointestinal symptoms. This review focuses on developments over the last 5 years that have led to changes in aspects of colonoscopy, including patient preparation, technical factors, therapeutic procedures, safety, and quality.