gebhart/patrepeval huggingface dataset:
Adaptive beam forming without signal cancellation in the presence of coherent jammers (1989)

Adaptive beam forming using spatial smoothing has been proposed to combat coherent jammers. Recently, it has been found that this adaptive beam forming technique cannot avoid signal cancellation phenomena while also rejecting coherent jammers. In the paper, an approach is presented to eliminate the interaction between the desired signal and coherent jammers during the adaptation of spatial smoothing. As a result, the proposed beam former can effectively null coherent jammers without signal cancellation. Moreover, the resulting output signal-to-noise ratio provides the information about the existence of the desired signal. Computer simulations confirm the theoretical work.
Bacterial pathogens — a route to oral drug delivery (1990)

Conference Article| October 01 1990 Bacterial pathogens — a route to oral drug delivery GORDON DOUGAN; GORDON DOUGAN 1Department of Molecular Biology, Wellcome Biotech Laboratories, Langley Court, Beckenham, Kent BR3 3BS, U.K. Search for other works by this author on: This Site PubMed Google Scholar STEVE CHATFIELD; STEVE CHATFIELD 1Department of Molecular Biology, Wellcome Biotech Laboratories, Langley Court, Beckenham, Kent BR3 3BS, U.K. Search for other works by this author on: This Site PubMed Google Scholar MARK ROBERTS; MARK ROBERTS 1Department of Molecular Biology, Wellcome Biotech Laboratories, Langley Court, Beckenham, Kent BR3 3BS, U.K. Search for other works by this author on: This Site PubMed Google Scholar IAN CHARLES; IAN CHARLES 1Department of Molecular Biology, Wellcome Biotech Laboratories, Langley Court, Beckenham, Kent BR3 3BS, U.K. Search for other works by this author on: This Site PubMed Google Scholar SARAH COMERFORD; SARAH COMERFORD 1Department of Molecular Biology, Wellcome Biotech Laboratories, Langley Court, Beckenham, Kent BR3 3BS, U.K. Search for other works by this author on: This Site PubMed Google Scholar LI JING LI; LI JING LI 1Department of Molecular Biology, Wellcome Biotech Laboratories, Langley Court, Beckenham, Kent BR3 3BS, U.K. Search for other works by this author on: This Site PubMed Google Scholar NEIL FAIRWEATHER NEIL FAIRWEATHER 1Department of Molecular Biology, Wellcome Biotech Laboratories, Langley Court, Beckenham, Kent BR3 3BS, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1990) 18 (5): 746–748. https://doi.org/10.1042/bst0180746 Article history Received: April 20 1990 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation GORDON DOUGAN, STEVE CHATFIELD, MARK ROBERTS, IAN CHARLES, SARAH COMERFORD, LI JING LI, NEIL FAIRWEATHER; Bacterial pathogens — a route to oral drug delivery. Biochem Soc Trans 1 October 1990; 18 (5): 746–748. doi: https://doi.org/10.1042/bst0180746 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1990 Biochemical Society1990 Article PDF first page preview Close Modal You do not currently have access to this content.
Reversible inhibitory effects and absence of toxicity of the tetrapeptide acetyl-N-Ser-Asp-Lys-Pro (AcSDKP) in human long-term bone marrow culture. (1992)

The effects of acetyl-N-Ser-Asp-Lys-Pro (Ac-SDKP) in human long-term bone marrow cultures (LTBMCs) were assessed by measuring the number of progenitors and the development of stromal cells over a 6-week course. In a first set of experiments, AcSDKP was added weekly at each medium change. Under these conditions, no significant effect of the peptide was observed. In contrast, by adding AcSDKP daily at 10(-10) M, the growth of the progenitors of the non-adherent (NA) compartment was inhibited by about 35%. This inhibition was entirely reversible; after stopping the addition of the peptide at the fourth week, the number of progenitors returned to control level within 2 weeks. Conversely, AcSDKP did not significantly change the number of the progenitors present in the adherent layer. In addition, AcSDKP did not affect the formation of the stromal layer nor induce the secretion of cytokines, such as tumor necrosis factor alpha (TNF-alpha), interleukin 1 beta (IL-1 beta), granulocyte colony-stimulating factor (G-CSF), interleukin 3 (IL-3), or interleukin 6 (IL-6). Our results indicate that AcSDKP has inhibitory but reversible effects on NA progenitors and does not induce long-term modifications of the microenvironment, both of particular interest for its clinical application.
Composition Dependence of the High Temperature Superconductivity in (Ba, Sr)-La-(Hg, Ag)-Cu-O System with K<sub>2</sub>NiF<sub>4</sub>-Type Structure (1987)

High T c superconductor M-La-Cu-O systems (M=Ba, Sr), with the composition (M x La 1- x ) 2 CuO 4- y , have been prepared by a ceramic technique and the compositional change of T c -value have been examined. Then in each of systems the partial substitution of Ag or Hg for Cu brought the increase of T c -value.
Synthesis of branched-phosphodiester and mannose-centered fucosylated glycoclusters and their binding studies with Burkholderia ambifaria lectin (BambL) (2013)

Five fucosylated glycoclusters exhibiting 4, 6 or 8 residues were synthesised with two different spatial environments based on mannose-centered and branched-phosphodiester scaffolds. Their synthesis was performed in solution using phosphoramidite chemistry to generate phosphodiester linkages, combined with Cu(I)-catalyzed azide–alkyne cycloaddition (CuAAC). The multivalent ligands were evaluated for their ability to bind to Burkholderia ambifaria Lectin (BambL). Binding evaluation was performed through inhibition of hemagglutination (HIA), surface plasmon resonance (SPR) and isothermal titration microcalorimetry (ITC). All fucosylated glycoclusters exhibited a higher affinity to BambL than methyl α-L-fucoside. A dissociation constant of 43 nM was observed for the fucocluster exhibiting four residues with the branched-phosphodiester spatial environment corresponding to a 22-fold increase in comparison with methyl α-L-fucoside. These multivalent fucoclusters represent the first example of ligands of high affinity to BambL.
On tear film breakup (TBU): dynamics and imaging (2016)

We report the results of some recent experiments to visualize tear film dynamics. We then study a mathematical model for tear film thinning and tear film breakup (TBU), a term from the ocular surface literature. The thinning is driven by an imposed tear film thinning rate which is input from in vivo measurements. Solutes representing osmolarity and fluorescein are included in the model. Osmolarity causes osmosis from the model ocular surface, and the fluorescein is used to compute the intensity corresponding closely to in vivo observations. The imposed thinning can be either one-dimensional or axisymmetric, leading to streaks or spots of TBU, respectively. For a spatially-uniform (flat) film, osmosis would cease thinning and balance mass lost due to evaporation; for these space-dependent evaporation profiles TBU does occur because osmolarity diffuses out of the TBU into the surrounding tear film, in agreement with previous results. The intensity pattern predicted based on the fluorescein concentration is compared with the computed thickness profiles; this comparison is important for interpreting in vivo observations. The non-dimensionalization introduced leads to insight about the relative importance of the competing processes; it leads to a classification of large vs small TBU regions in which different physical effects are dominant. Many regions of TBU may be considered small, revealing that the flow inside the film has an appreciable influence on fluorescence imaging of the tear film.
Localization of cyclic AMP-dependent protein kinase subunits in rat hepatocyte nuclei by immunogold electron microscopy (1984)

We have applied the indirect colloidal immunogold technique to examine the ultrastructural localization of the catalytic subunit C and the regulatory subunits RI and RII of cyclic AMP-dependent protein kinase in rat hepatocyte nuclei before and after glucagon or dibutyryl cyclic AMP administration. The technique allowed the identification and localization of all three subunits in hepatocyte nuclei. Morphometric quantitation of the relative staining density of nuclear subunits indicated an increase of immunogold staining of nuclear catalytic subunit but not of the regulatory subunits after glucagon or dibutyryl cyclic AMP stimulation. The increase of catalytic subunit occurred in a biphasic manner with peak levels 2-30 min and 90-150 min after stimulation. Our experiments represent the first reported use of the immunogold procedure to identify and localize protein kinase subunits in the nucleus.
Simultaneous multithreading: Maximizing on-chip parallelism (2002)

This paper examines simultaneous multithreading, a technique permitting several independent threads to issue instructions to a superscalar's multiple functional units in a single cycle. We present several models of simultaneous multithreading and compare them with alternative organizations: a wide superscalar, a fine-grain multithreaded processor, and single-chip, multiple-issue multiprocessing architectures. Our results show that both (single-threaded) superscalar and fine-grain multithreaded architectures are limited in their ability to utilize the resources of a wide-issue processor. Simultaneous multithreading has the potential to achieve 4 times the throughput of a superscalar, and double that of fine-grain multi-threading. We evaluate several cache configurations made possible by this type of organization and evaluate tradeoffs between them. We also show that simultaneous multithreading is an attractive alternative to single-chip multiprocessors; simultaneous multithreaded processors with a variety of organizations outperform corresponding conventional multiprocessors with similar execution resources. While simultaneous multithreading has excellent potential to increase processor utilization, it can add substantial complexity to the design. We examine many of these complexities and evaluate alternative organizations in the design space.
Experience with a computerized stereoscopic workstation for neurosurgical planning (2002)

The authors describe a PC AT-based workstation that allows stereotactic neurosurgery to be planned using stereoscopic digital subtraction angiography (DSA) projections in conjunction with computed tomography (CT) and/or magnetic resonance (MR) image data. Techniques for correlating the positions of targets and for performing measurements in images acquired from different modalities (i.e., CT, MR and DSA) are presented. The stereoscopic approach is discussed and compared with conventional methods of planning stereotactic neurosurgery. This method is found to be enlightening in terms of its ability to provide the observer with a 3D appreciation of the imaged structure. The ability to perform quantitative measurements, as well as view projection image data in 3D, is an attractive feature of the stereoscopic workstation and is considered crucial to planning many stereotactic procedures.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Adaptive spectrum exploitation using emerging software defined radios (2003)

Radio frequency interference (RFI) caused by commercial and military spectrum crowding is a growing problem for digital battlefield communication systems. Current electromagnetic spectrum planning generally involves static frequency allocations that are difficult to modify after force insertion. Currently, no real time spectrum management systems exist to coordinate the dynamic spectrum environment experienced by mobile military communications. The DoD's plans for the Joint Tactical Radio System (JTRS) indicate that software defined radios (SDR) will be key components of the future battlefield. We investigate battlefield spectrum efficiency problems caused by RFI, and propose near term solutions that exploit the capabilities of emerging software defined radios to provide real time spectrum planning and frequency adaptation.
Coupling of flagellin gene transcription to flagellar assembly in Bacillus subtilis (1994)

The regulation of flagellin gene expression in Bacillus subtilis was examined in vivo by means of a lacZ translational fusion to the flagellin structural gene (hag). We have tested the effects of two known mutations (flaA4 and flaA15) in the major flagellar operon and of three deletions. One deletion was in frame in the fliI cistron, one was out of frame in the fliK cistron, and the last spanned about 21 kb of the flaA operon. In all instances, the expression of the flagellin gene was defective. Flagellin gene expression was restored in the strain with the 21-kb deletion by overexpression of the sigD gene under control of the isopropyl-beta-D-thiogalactopyranoside (IPTG)-inducible spac promoter. These results indicate that transcription of the flagellin gene is dependent on the formation of the flagellar basal body but that such a requirement can be bypassed by overexpression of sigD. Lack of expression of hag was observed in the presence of flaD1, flaD2, and delta sin mutations as well.
Theory, Instrumentation, and Applications of Electron Paramagnetic Resonance Oximetry (2010)

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTTheory, Instrumentation, and Applications of Electron Paramagnetic Resonance OximetryRizwan Ahmad and Periannan Kuppusamy*View Author Information Center for Biomedical EPR Spectroscopy and Imaging, Davis Heart and Lung Research Institute, Department of Internal Medicine, The Ohio State University, Columbus, Ohio 43210* To whom correspondence should be addressed. E-mail: [email protected]Cite this: Chem. Rev. 2010, 110, 5, 3212–3236Publication Date (Web):March 10, 2010Publication History Received8 December 2009Published online10 March 2010Published inissue 12 May 2010https://pubs.acs.org/doi/10.1021/cr900396qhttps://doi.org/10.1021/cr900396qreview-articleACS PublicationsCopyright © 2010 American Chemical SocietyRequest reuse permissionsArticle Views3538Altmetric-Citations127LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Electron paramagnetic resonance spectroscopy,Oxygen,Probes,Quantum mechanics,Saturation Get e-Alerts
Thymus and immune reconstitution after allogeneic hematopoietic stem cell transplantation in humans: never say never again (2012)

Assessment of the host immune status is becoming a key issue in allogeneic hematopoietic stem cell transplantation (allo-HSCT). In the long-term follow-up of these patients, severe post-transplant infections, relapse or secondary malignancies may be directly related to persistent immune defects. In allo-HSCT, T-cell differentiation of donor progenitors within the recipient thymus is required to generate naive recent T-cell emigrants (RTE). These cells account for a durable T-cell reconstitution, generating a diverse T-cell receptor (TCR) repertoire and robust response to infections. It is now possible to quantify the production of RTE by measuring thymic T-cell receptor excision circles or 'TREC' which are small circular DNA produced during the recombination of the genomic segments encoding the TCR alpha chain. Here we discuss the role of thymic function in allo-HSCT. The pre-transplant recipient thymic function correlates with clinical outcome in terms of survival and occurrence of severe infections. Post-transplant, TREC analysis showed that the thymus is a sensitive target to the allogeneic acute graft-versus-host disease (GvHD) reaction but is also prone to recovery in young adult patients. In all, thymus is a key player for the quality of immune reconstitution and clinical outcome after allo-HSCT. Thymic tissue is plastic and it is a future challenge to halt or reverse thymic GVHD therapeutically by acting at the level of T-cell progenitors generation, thymic homing and/or epithelial thymic tissue preservation.
Function-Spacer-Lipid (FSL) constructs enable inkjet printing of blood group antigens (2011)

A limitation of inkjet printing antigens to solid surfaces is that the molecule to be printed must be dispersible in solution, retain antigenicity, and remain on the printed surface when exposed to biological solutions. FSL (function-spacer-lipid) constructs were designed to be dispersible in water and to attach a range of synthetic molecules to cell membranes. FSL constructs currently include carbohydrates, peptides, fluorophores, ligands and biotin and are being used in the manufacture of modified cells called ‘‘kodecytes’’ for use in blood group typing laboratories and for research purposes (1–2). FSL constructs have now been used to create prototype diagnostic assay kits, using standard desktop inkjet printers, by simply replacing the ink in a spent cartridge with a solution of FSL construct. The FSL constructs can then be printed onto a substrate in much the same way one might print a letter or drawing on a sheet of paper. Blood group FSLs have been printed onto silica and nitrocellulose surfaces, and used to identify blood group antibodies in diagnostic and research samples. Combining FSL technology with existing inkjet printing technology provides a cost effective alternative to existing methods of manufacturing diagnostic test kits, including microarrays which, for the most part, use robotics. In addition to cost savings the versatility of this manufacturing method provides additional benefits for research laboratories and micro-analyses. Acknowledgement: Supported by KODE Biotech Ltd (kodebiotech.com)
Integer MDCT with enhanced approximation of the DCT-IV (2006)

Integer transform plays an important role in lossless signal compression. In order to achieve high accuracy to its corresponding theoretical transform, the rounding number should be as low as possible. At the same time, the matrix factorization for reversible integer mapping should be handled with care, especially when the processing block length is high (N>16). In this correspondence, a new method for realizing reversible integer discrete cosine transform type IV (DCT-IV) is proposed that is a key component used in audio compression. The proposed method exhibits low rounding number (2.5N) and low complexity O(Nlog/sub 2/N) as well as well as accurately represents its counterpart floating-point DCT-IV transformation.
Le plan agricole dans l'ensemble de la planification (1962)

Ripert Jean. Le plan agricole dans l'ensemble de la planification. In: Économie rurale. N°54, 1962. Aspects de la planification agricole française (1e partie) pp. 3-6.
The impact of platelet transfusion characteristics on posttransfusion platelet increments and clinical bleeding in patients with hypoproliferative thrombocytopenia (2012)

Platelet characteristics, such as platelet dose, platelet source (apheresis vs pooled), platelet donor-recipient ABO compatibility, and duration of platelet storage, can affect posttransfusion platelet increments, but it is unclear whether these factors impact platelet transfusion efficacy on clinical bleeding. We performed secondary analyses of platelet transfusions given in the prospective randomized Platelet Dose Study, which included 1272 platelet-transfused hematology-oncology patients who received 6031 prophylactic platelet transfusions. The primary outcome of these analyses was time from first transfusion to first World Health Organization ≥ grade 2 bleeding. Platelet transfusion increments were assessed at 0.25 to 4 hours and 16 to 32 hours after platelet transfusion. There were 778 patients evaluable for analysis of time to bleeding. Adjusted models showed that randomized dose strategy, platelet source, ABO compatibility, and duration of storage did not predict this outcome. Platelet increments were generally higher for transfusions of apheresis platelets, ABO-identical platelets, and platelets stored 3 days versus 4 to 5 days. Thus, although platelet source, ABO compatibility, and duration of storage exert a modest impact on both absolute and corrected posttransfusion platelet increments, they have no measurable impact on prevention of clinical bleeding. This trial was registered at www.clinicaltrials.gov as #NCT00128713.
Production and characterization of monoclonal antibodies specific for Cryptococcus neoformans capsular polysaccharide (1987)

Cryptococcus neoformans is surrounded by a capsular polysaccharide. There are at least four known serotypes of the polysaccharide. The objective of this study was to produce monoclonal antibodies (MAbs) that could be used to study the distribution of epitopes among the serotypes of C. neoformans. BALB/c mice were immunized with cryptococcal polysaccharides of serotype A or D that were coupled to sheep erythrocytes. Splenocytes were isolated, and hybridomas secreting MAbs specific for cryptococcal polysaccharides were isolated. Two hybridomas, designated MAbs 439 and 1255, were produced from mice immunized with serotype A polysaccharide. One hybridoma, designated MAb 302, was produced from mice immunized with serotype D polysaccharide. All three antibodies were of the immunoglobulin G1 isotype. MAb 302 showed a specificity for serotypes A and D in Ouchterlony diffusion, agglutination, and opsonophagocytosis assays. MAb 1255 was reactive with polysaccharides and cells of serotypes A, B, and D. MAb 439 was reactive with polysaccharides and cells of serotypes A, B, C, and D. The reactivity of these MAbs closely matched the distribution of epitopes among cryptococcal polysaccharides predicted in previous studies of polyclonal antibodies reactive with cryptococcal polysaccharides. The ability to produce a MAb against an epitope shared by all four serotypes may have value for the detection of cryptococcal antigens in body fluids.
Antiretroviral Therapy and the Lipodystrophy Syndrome (2001)

'Lipodystrophy syndrome' in the setting of HIV infection has come to encompass a collection of morphological and metabolic abnormalities linked with the use of antiretroviral therapy and other risk factors. We review the clinical literature on this subject as it has evolved historically, taking pertinent methodological issues into account.