gebhart/patrepeval huggingface dataset:
Polar Group Burial Contributes More to Protein Stability than Nonpolar Group Burial (2000)

Acetylcholine (1-10(-5) g/ml) was shown to increase the content of active form of phosphorylase A in homogenate of cat skeletal muscle. Atropine (1-10(-5) g/ml) diminished acetylcholine-induced increase in the phosphorylase activity from 22% to 5.28%. Activating effect of acetylcholine was observed also in superatant (105000 g), although it was 2-fold decreased. No acetylcholine-induced phosphorylase activation was observed in the presence of Mg2+. Addition of Ca2+ (2.2-10(-14) M) did not affect considerably the activation process. It is concluded that the mechanism of acetylcholine-induced phosphorylase activation is different from the effect of adrenaline on phosphorylase.
Patients with a phenotype consistent with facioscapulohumeral muscular dystrophy display genetic and epigenetic heterogeneity (2011)

In patients presenting with an FSHD-like clinical phenotype with a negative molecular testing for FSHD, consider (1) detailed genetic testing including D4Z4 contraction of permissive hybrid D4Z4 repeat arrays, p13E-11 probe deletions, and D4Z4 hypomethylation in the absence of repeat contraction as observed in FSHD2; (2) mutations in CAPN3 even in the absence of protein deficiency on western blot analysis; and (3) VCP mutations even in the absence of cognitive impairment, Paget disease and typical inclusion in muscle biopsy.
Synthetic and mechanistic aspects of the photocyclization of 2-(β-arylvinyl)biphenyls into 9-aryl-9,10-dihydrophenanthrenes (1978)

The synthesis is described of several 2-(β-arylvinyl)biphenyls (4c), some of which contain deuterium on C-2′–6′(14c). On irradiation they yield 9-aryl-9,10-dihydrophenanthrenes (6c) in which the isotope if present is found on C-5–8 and at the cis- or trans-position of C-10 (15c). The photoreaction consists of a stereoselective, probably concerted, conrotatory cyclization from the S1 state of both cis- and trans-(4c) to a 9-aryl-8a,9-dihydrophenanthrene derivative (5c), followed by a thermal, suprafacial [1,5] sigmatropic hydrogen shift. The rate of the hydrogen shift is so fast that (5c) cannot be detected spectroscopically in the reaction mixture and equally is not oxidized by dissolved oxygen to a 9-arylphenanthrene (9c), which does arise in the presence of iodine as oxidant.
Decomposition of Time Deviation and Inadvertent Interchange on InterConnected Systems Part I : Identification, Separtion and Measurement of Components (1982)

This paper introduces the concept that time deviation and inadvertent interchange accumulated during a designated time span are comprised of and equal to the algebraic sum of separable and measurable components, in number equal to the number of control areas of the interconnected system, each component resulting from and hence a measure of the effects of regulating deficiencies including schedule offsets in the corresponding area. Techniques for measuring the components are described. A companion paper discusses and illustrates the utilization of these components for the evaluation of area control performance including possible assessment of penalties to delinquent areas, and for more equitable and economic corrective control of unscheduled bulk power transfers.
Camera calibration from video of a walking human (2006)

A self-calibration method to estimate a camera's intrinsic and extrinsic parameters from vertical line segments of the same height is presented. An algorithm to obtain the needed line segments by detecting the head and feet positions of a walking human in his leg-crossing phases is described. Experimental results show that the method is accurate and robust with respect to various viewing angles and subjects.
Wideband Low-Loss Magnetoelectric Dipole Antenna for 5G Wireless Network With Gain Enhancement Using Meta Lens and Gap Waveguide Technology Feeding (2016)

In this paper, a wideband magnetoelectric (ME) dipole antenna excited by a slot coupled to a fork-shaped printed ridge gap waveguide is proposed. To enhance the antenna gain, a meta lens consists of three layers of split ring resonators (SRRs) are integrated horizontally in front of the ME dipole antenna. Each slab contains a 3×7 array of SRR unit cells. The matching bandwidth is improved as a secondary effect of the lens. A 1 × 4 array is designed to provide more gain by adjusting the lens between the edge elements of the four-element array. The antenna is fabricated and tested. The measured results show that -10 dB S <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">11</sub> is obtained between 26.5 and 38.3 GHz. The measure realized gain is better than 15 dBi over the frequency range of 28-38 GHz. A 90% radiation efficiency at 30 GHz is achieved.
THE USE OF THEOPHYLLINE ETHYLENEDIAMINE (AMINOPHYLLINE) FOR THE RELIEF OF BILIARY COLIC: A PRELIMINARY REPORT (1944)

Our purpose in this communication is to call attention to the use of theophylline ethylenediamine for the relief of biliary colic. For many years it has been known that the xanthines are capable of relaxing certain smooth muscles. Thus, theophylline has been employed for symptomatic relief of patients with angina pectoris and bronchial asthma.1The antispasmodic action of theophylline, however, is not manifested to any great extent on the gastrointestinal tract. Nevertheless, it has been shown by Butsch, McGowan and Walters2that theophylline ethylenediamine is effective in overcoming spasm of the biliary tract produced in man by the injection of morphine, dihydromorphinone hydrochloride (dilaudid) or codeine. It is well known that the phenanthrene alkaloids of opium produce spasm of smooth muscles of hollow viscera. Morphine relieves pain due to such spasm only by virtue of its analgesic action on the central nervous system. Locally, the mechanism for the
A Prospective, Randomized Comparison of the Metabolic Effects of Pioglitazone or Rosiglitazone in Patients With Type 2 Diabetes Who Were Previously Treated With Troglitazone (2002)

Differing effects on lipid profile were apparent after random conversion from TROG to either PIO or ROSI, despite similar weight increase and glycemic control. The clinical significance of these differences remains to be determined, and further comparative research is warranted.
Phenotype-genotype relationships in PEX10-deficient peroxisome biogenesis disorder patients (2000)

The peroxisome biogenesis disorders (PBD) are characterized by neural, hepatic, and renal deficiencies, severe mental retardation, and are often lethal. These disorders are genetically and phenotypically heterogeneous and are caused by defective peroxisomal protein import and decreased peroxisomal metabolic function. Mutations in PEX10 have been identified in patients from complementation group 7 (CG7) of the PBDs and we report here an analysis of the genotypes and phenotypes of PEX10-deficient patients. All four PEX10-deficient Zellweger Syndrome (ZS) patients were found to have nonsense, frameshift, or splice site mutations that remove large portions of the PEX10 coding region. In contrast, a more mildly affected PEX10-deficient neonatal adrenoleukodystrophy patient expressed a PEX10 allele with a missense mutation, H290Q, affecting the C-terminal zinc-binding domain of the PEX10 product. These results support the hypothesis that severe, loss-of-function mutations in PEX genes cause more severe clinical phenotypes, whereas mildly affected PBD patients have PEX gene mutations that retain residual function. To quantitate the effects of the PEX10 mutations identified here and elsewhere we employed a functional complementation assay. Surprisingly, we observed that nonsense and frameshift mutations predicted to delete the C-terminal 2/3 (R125X) or 1/3 (c.704insA) of the protein displayed nearly normal PEX10 activity. Even more surprising, we found that the unexpectedly high PEX10 activity displayed by these cDNAs could be eliminated by removing or mutating segments of the PEX10 cDNA downstream of the mutations. Although these results demonstrate serious flaws in the PEX10 functional complementation assay, they do suggest that the C-terminal zinc-binding domain is critical for PEX10 function. Hum Mutat 15:509–521, 2000. © 2000 Wiley-Liss, Inc.
Augmenting overlay trees for failure resiliency (2005)

Overlay trees typically use directed trees as efficient structures for disseminating information, but their single-path structure means that just one node failure results in the disconnection of all descendants, possibly a significant portion of the graph. The addition of extra "backup" links to a directed tree can provide alternate data paths that significantly reduce the number of nodes disconnected when some set of nodes are removed from the graph. We investigate several deterministic and randomized algorithms for adding such backup links to a directed tree and analyze the connectedness of the resulting graphs when nodes in the network fail with some random probability. We present closed-form approximations and simulation measurements for the connectivity of these augmented trees in networks ranging from hundreds to hundreds of thousands of nodes. We also identify and measure the costs of adding backup links, using simulations and real-world measurements from overlays constructed using PlanetLab latency data. We find that, with node failure rates up to 10%, deterministic backup link selection policies offer comparable resiliency to random backup links with significantly lower overhead and resource usage.
Transcoding Method of H.264 Coded Bitstream for Interest Region (2009)

We propose a transcoding method of H.264 coded bitsteam to control the picture quality dependently on the interest region. In the proposed method, first we find the model of quantization step-size and bitrate. Then a classification method according to the subjectively interest region within a video sequence is suggested. Also we propose a method that assigns a specific quantization step-size differentially according to the interest region within a video. In general, the subjective picture quality can be increased by applying the quantization step-size as a small value relatively for the interest region compared with the other regions. From the simulation, we show that the proposed method can make better subjective picture quality relatively in parts of interest region.
A proof of Nielsen's conjecture on the GPS dilution of precision (1998)

The dilution of precision terms for relative positioning are bounded from above by the corresponding dilution of precision terms for point positioning. This result is proven for the case of four satellites and conjectured to be valid for the case of more than four satellites. A proof of this conjecture is given. We also extend the result by giving two different lower bounds for the dilution of precision terms. The first lower bound depends on the receiver-satellite geometry, whereas the second does not. The proof of the bounds is based on the solution of a generalized eigenvalue problem.
Temporal dynamics of ipsilateral and contralateral motor activity during voluntary finger movement (2004)

Abstract The role of motor activity ipsilateral to movement remains a matter of debate, due in part to discrepancies among studies in the localization of this activity, when observed, and uncertainty about its time course. The present study used magnetoencephalography (MEG) to investigate the spatial localization and temporal dynamics of contralateral and ipsilateral motor activity during the preparation of unilateral finger movements. Eight right‐handed normal subjects carried out self‐paced finger‐lifting movements with either their dominant or nondominant hand during MEG recordings. The Multi‐Start Spatial Temporal multi‐dipole method was used to analyze MEG responses recorded during the movement preparation and early execution stage (−800 msec to +30 msec) of movement. Three sources were localized consistently, including a source in the contralateral primary motor area (M1) and in the supplementary motor area (SMA). A third source ipsilateral to movement was located significantly anterior, inferior, and lateral to M1, in the premotor area (PMA) (Brodmann area [BA] 6). Peak latency of the SMA and the ipsilateral PMA sources significantly preceded the peak latency of the contralateral M1 source by 60 msec and 52 msec, respectively. Peak dipole strengths of both the SMA and ipsilateral PMA sources were significantly weaker than was the contralateral M1 source, but did not differ from each other. Altogether, the results indicated that the ipsilateral motor activity was associated with premotor function, rather than activity in M1. The time courses of activation in SMA and ipsilateral PMA were consistent with their purported roles in planning movements. Hum. Brain Mapp. 23:26–39, 2004. © 2004 Wiley‐Liss, Inc.
Olig2 and Ngn2 function in opposition to modulate gene expression in motor neuron progenitor cells (2005)

Spinal motor neurons and oligodendrocytes are generated sequentially from a common pool of progenitors termed pMN cells. Olig2 is a bHLH-class transcription factor in pMN cells, but it has remained unclear how its transcriptional activity is modulated to first produce motor neurons and then oligodendrocytes. Previous studies have shown that Olig2 primes pMN cells to become motor neurons by triggering the expression of Ngn2 and Lhx3. Here we show that Olig2 also antagonizes the premature expression of post-mitotic motor neuron genes in pMN cells. This blockade is counteracted by Ngn2, which accumulates heterogeneously in pMN cells, thereby releasing a subset of the progenitors to differentiate and activate expression of post-mitotic motor neuron genes. The antagonistic relationship between Ngn2 and Olig2 is mediated by protein interactions that squelch activity as well as competition for shared DNA-binding sites. Our data support a model in which the Olig2/Ngn2 ratio in progenitor cells serves as a gate for timing proper gene expression during the development of pMN cells: Olig2(high) maintains the pMN state, thereby holding cells in reserve for oligodendrocyte generation, whereas Ngn2(high) favors the conversion of pMN cells into post-mitotic motor neurons.
HEMISPHERIC CENTER FOR ENVIRONMENTAL TECHNOLOGY (2000)

The Online Measurement of Decontamination project team received a commitment for a demonstration in May from the Sacramento (California) Municipal Utility District (SMUD) Rancho Seco site. Since this site is a member of the DOE Commercial Utilities Consortium, the demonstration will fulfill the DOE and commercial technology demonstration requirements. Discussion on deployment of the Integrated Vertical and Overhead Decontamination (IVOD) System at Rancho Seco was conducted; date for deployment tentatively scheduled for early spring. Based upon fictional requirements from SRS for a shiny monitor in a high-level waste tank, FIU-HCET developed and delivered a draft slurry monitor design and draft test plan. Experiments measuring slurry settling time for SRS slurry simulant at 10 wt% have been completed on FIU-HCET'S flow loop with SRS dip. The completed design package of the test mockup for evaluating Non-Intrusive Location of Buried Items Technologies was sent to Fluor Fernald and the Operating Engineers National Hazmat Program for review. Comments are due at the end of January. Preliminary experiments to determine size distribution of aerosols generated during metal cutting were performed. A 1/4-inch-thick iron plate was cut using a plasma arc torch, and the size distribution of airborne particles was measured using a multistage impactor. Per request of DOE-Ohio, FIU-HCET participated in a weeklong value engineering study for the characterization, decontamination, and dismantlement of their critical path facility.
Modes of Action of the New Arylguanidine Abafungin beyond Interference with Ergosterol Biosynthesis and in vitro Activity against Medically Important Fungi (2008)

The observed characteristics of abafungin indicate that abafungin might be a promising antifungal agent defining a new class of antimycotics.
ECG Arrhythmias Recognition System Based on Independent Component Analysis Feature Extraction (2006)

Automatic recognition of cardiac arrhythmias is important for diagnosis of cardiac abnormalities. This paper presents a new approach to classification ECG signals based on feature extraction to diagnose heartbeat irregularities. We introduce the independent component analysis (ICA) feature extraction method and propose an over-complete feature extraction method combining ICA basis function's coefficients and wavelet transform coefficients. A set of relevant features are selected from the entire overcomplete features using a relevant feature selection method. The selected features are used to trained a support vector machine classifier to recognize different heartbeat arrhythmias. From computer simulations, the proposed method yields a more satisfactory classification results on the MIT-BIH arrhythmia database than the other existing methods, reaching an overall accuracy of 98.65%
Detection of Different Hypoxic Cell Subpopulations in Human Melanoma Xenografts by Pimonidazole Immunohistochemistry (2008)

This study aimed at developing immunohistochemical assays for different subpopulations of hypoxic cells in tumors. BALB/c-nu/nu mice bearing A-07 or R-18 tumors were given a single dose of 90 mg/kg body weight or three doses (3 h apart) of 30 mg/kg body weight of pimonidazole hydrochloride intravenously. The fraction of pimonidazole-labeled cells was assessed in paraffin-embedded and frozen tumor sections and compared with the fraction of radiobiologically hypoxic cells. The staining pattern in paraffin-embedded sections indicated selective staining of chronically hypoxic cells. Frozen sections showed a staining pattern consistent with staining of both chronically and acutely/repetitively hypoxic cells. Fraction of pimonidazole-labeled cells in paraffin-embedded sections was lower than the fraction of radiobiologically hypoxic cells (single-dose and triple-dose experiment). In frozen sections, fraction of pimonidazole-labeled cells was similar to (single-dose experiment) or higher than (triple-dose experiment) fraction of radiobiologically hypoxic cells. Three different subpopulations of hypoxic cells could be quantified by pimonidazole immunohistochemistry: the fraction of cells that are hypoxic because of limitations in oxygen diffusion, the fraction of cells that are hypoxic simultaneously because of fluctuations in blood perfusion, and the fraction of cells that are exposed to one or more periods of hypoxia during their lifetime because of fluctuations in blood perfusion.
Global DNA Demethylation During Mouse Erythropoiesis in Vivo (2011)

In the mammalian genome, 5'-CpG-3' dinucleotides are frequently methylated, correlating with transcriptional silencing. Genome-wide demethylation is thought to occur only twice during development, in primordial germ cells and in the pre-implantation embryo. These demethylation events are followed by de novo methylation, setting up a pattern inherited throughout development and modified only at tissue-specific loci. We studied DNA methylation in differentiating mouse erythroblasts in vivo by using genomic-scale reduced representation bisulfite sequencing (RRBS). Demethylation at the erythroid-specific β-globin locus was coincident with global DNA demethylation at most genomic elements. Global demethylation was continuous throughout differentiation and required rapid DNA replication. Hence, DNA demethylation can occur globally during somatic cell differentiation, providing an experimental model for its study in development and disease.
PRESSURE AND SPECIFIC PRECIPITATION (1946)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPRESSURE AND SPECIFIC PRECIPITATIONDan H. Campbell and Frank H. JohnsonCite this: J. Am. Chem. Soc. 1946, 68, 4, 725Publication Date (Print):April 1, 1946Publication History Published online1 May 2002Published inissue 1 April 1946https://pubs.acs.org/doi/10.1021/ja01208a516https://doi.org/10.1021/ja01208a516research-articleACS PublicationsRequest reuse permissionsArticle Views33Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Molecular Recognition of 6′-<i>N</i>-5-Hexynoate Kanamycin A and RNA 1x1 Internal Loops Containing CA Mismatches (2011)

In our previous study to identify the RNA internal loops that bind an aminoglycoside derivative, we determined that 6'-N-5-hexynoate kanamycin A prefers to bind 1x1 nucleotide internal loops containing C·A mismatches. In this present study, the molecular recognition between a variety of RNAs that are mutated around the C·A loop and the ligand was investigated. Studies show that both loop nucleotides and loop closing pairs affect binding affinity. Most interestingly, it was shown that there is a correlation between the thermodynamic stability of the C·A internal loops and ligand affinity. Specifically, C·A loops that had relatively high or low stability bound the ligand most weakly whereas loops with intermediate stability bound the ligand most tightly. In contrast, there is no correlation between the likelihood that a loop forms a C-A(+) pair at lower pH and ligand affinity. It was also found that a 1x1 nucleotide C·A loop that bound to the ligand with the highest affinity is identical to the consensus site in RNAs that are edited by adenosine deaminases acting on RNA type 2 (ADAR2). These studies provide a detailed investigation of factors affecting small molecule recognition of internal loops containing C·A mismatches, which are present in a variety of RNAs that cause disease.
Reconfiguraciones de debates y posiciones del campo literario argentino en el Semanario La Nota 1915-1920 / Debate Reconfigurations and Positions of the Argentine Literary Field on the weekly La Nota 1915-1920 (2018)

Este trabajo toma como objeto de análisis el semanario La Nota (Buenos Aires, 1915- 1920) al que considera como espacio discursivo fundamental para focalizar y estudiar las reconfiguraciones del campo literario argentino de esos años. Estas reconfiguraciones se ligan con cambios políticos (la efectivización de la ley Sáenz Peña en 1916) y con procesos de modemización social (políticas exitosas de alfabetización). La conformación de un nuevo público lector, que consume preferentemente diarios, periódicos y folletines, convierte al mercado y al público en preocupaciones centrales del mundo literario y de este semanario en particular. El trabajo reconoce en la publicación una serie de rasgos de la prensa periódica más modema y popular junto con otros que remiten a la prensa política y de elite y este hecho le otorga un carácter singular. Como semanario modemo, la revista pone su acento en el mercado de lectura y escritura; como semanario político, intenta ejercer sobre ese público una forma fundamentalmente ideológica de pedagogía, puesto que la revista lleva adelante una campaña antigermana durante la Gran Guerra, la cual aparece como tema insoslayable del campo literario.