gebhart/patrepeval huggingface dataset:
Characterization of Revertants of <i>unc-93(e1500)</i> in <i>Caenorhabditis elegans</i> Induced by <i>N</i>-ethyl-<i>N</i>-nitrosourea (1997)

Phenotypic reversion of the rubber-band, muscle-defective phenotype conferred by unc-93(e1500) was used to determine the utility of N-ethyl-N-nitrosourea (ENU) as a mutagen for genetic research in Caenorhabditis elegans. In this system, ENU produces revertants at a frequency of 3 × 10–4, equivalent to that of the commonly used mutagen, EMS. The gene identity of 154 ENU-induced revertants shows that the distribution of alleles between three possible suppressor genes differs from that induced by EMS. A higher percentage of revertants are alleles of unc-93 and many fewer are alleles of sup-9 and sup-10. Three revertants complement the three known suppressor genes; they may therefore identify a new gene product(s) involved in this system of excitation-contraction coupling in C. elegans. Molecular characterization of putative unc-93 null alleles reveals that the base changes induced by ENU are quite different from those induced by EMS; specifically we see an increased frequency of A/T → G/C transitions. The frequency of ENU-induced intragenic deletions is found to be 13%. We suggest that ENU, at concentrations below 5 mm, will be a superior mutagen for studies of protein function in C. elegans.
Expiratory Pharyngeal Airway Obstruction During Sleep: A Multiple Element Model (2003)

During expiration, the supraglottic/retroglossal level is obstructed more frequently and has greater compliance than the retropalatal segment. Failure of upstream pressures to describe pharyngeal obstruction supports a multi-element model of collapse. Segments interact during expiration, with increased retropalatal collapse on obstructed as compared with nonobstructed breaths. Increased collapse on expiration provides a mechanism for increased obstruction on subsequent inspiratory breaths.
Modified peptide monolayer binding His-tagged biomolecules for small ligand screening with SPR biosensors (2011)

A peptide self-assembled monolayer (SAM) was designed to bind His-tagged biomolecules for surface plasmon resonance (SPR) bioanalysis, which was applied for the determination of K(d) for small ligand screening against CD36. Nonspecific adsorption could be minimized using penta- and hexa-peptide monolayers. In particular, monolayers consisting of 3-mercaptopropionyl-leucinyl-histidinyl-aspartyl-leucinyl-histidinyl-aspartic acid (3-Mpa-LHDLHD) exhibited little (12 ng cm(-2)) nonspecific adsorption in crude serum. Modification of this peptide monolayer with Nα,Nα-bis(carboxymethyl)-L-lysine gave a surface competent for binding His-tagged proteins, as demonstrated using enzyme (human dihydrofolate reductase), protein/antibody and receptor (CD36) examples. Immobilization featured chelation of copper and the His-tagged protein by the peptide monolayer, which could be recycled by removing the copper using imidazole washes prior to reuse.
Purification and characterization of two unique forms of cytochrome P-450 from rabbit nasal microsomes (1988)

Two forms of cytochrome P-450, designated P-450NMa and P-450NMb, were purified to electrophoretic homogeneity from rabbit nasal microsomes. The purified cytochromes, which contained 14-16 nmol of P-450/mg of protein, exhibited apparent monomeric molecular weights of 49,500 and 51,000, respectively. As indicated by several criteria, including the amino acid composition, absorption spectra, and peptide maps, the two nasal forms of P-450 are distinct from each other. Furthermore, as judged by the NH2-terminal amino acid sequences, they are distinct from all other P-450 cytochromes described to date. In the ferric form, P-450NMa is in the low-spin state, whereas P-450NMb is predominantly in the high-spin state. When reconstituted with NADPH-cytochrome P-450 reductase and phospholipid, P-450NMa is very active in the oxidation of ethanol as well as several nasal procarcinogens, including the N-deethylation of N-nitrosodiethylamine, the O-deethylation of phenacetin, and the N-demethylation of hexamethyl-phosphoramide. P-450NMb also metabolizes these substrates, but at lower rates. Both nasal forms are also active with testosterone, with P-450NMa oxidizing the substrate in the 17-position to give androstenedione and P-450NMb catalyzing hydroxylation in the 15 alpha-, 16 alpha-, and 19-positions. The two cytochromes represent the major portion of the total P-450 in nasal microsomes, but the corresponding forms could not be detected in hepatic microsomes.
Field modulation in Na-incorporated Cu(In,Ga)Se2 (CIGS) polycrystalline films influenced by alloy-hardening and pair-annihilation probabilities (2011)

The influence of Na on Cu(In,Ga)Se2 (CIGS) solar cells was investigated. A gradient profile of the Na in the CIGS absorber layer can induce an electric field modulation and significantly strengthen the back surface field effect. This field modulation originates from a grain growth model introduced by a combination of alloy-hardening and pair-annihilation probabilities, wherein the Cu supply and Na diffusion together screen the driving force of the grain boundary motion (GBM) by alloy hardening, which indicates a specific GBM pinning by Cu and Na. The pair annihilation between the ubiquitously evolving GBMs has a coincident probability with the alloy-hardening event.PACS: 88. 40. H-, 81. 10. Aj, 81. 40. Cd.
Potentiation of organophosphorus‐induced delayed neurotoxicity by phenylmethylsulfonyl fluoride (1990)

It is well known that pretreatment with the serine esterase inhibitor phenylmethylsulfonyl fluoride (PMSF) can protect experimental animals from organophosphorus-induced delayed neurotoxicity (OPIDN), presumably by blocking the active site of neurotoxic esterase (NTE) such that binding and "aging" of the neuropathic OP is thwarted. We report here that while PMSF (60 mg/kg, sc) given 4 h before the neuropathic organophosphate (OP) mipafox (50 mg/kg, im) completely prevented the clinical expression of OPIDN in hens, the identical PMSF treatment markedly amplified the delayed neurotoxicity (relative to hens treated with OP only) if administered 4 h after mipafox (5 or 50 mg/kg, im). Moreover, in a separate experiment using diisopropylphosphorofluoridate (DFP) as the neurotoxicant in place of mipafox, posttreatment with PMSF 4 h after DFP (0.5 mg/kg) also accentuated the severity of ataxia. These data indicate that PMSF only protects against OPIDN if given prior to exposure to the neurotoxicant; treatment with PMSF after OP exposure critically exacerbates the delayed neurotoxicity from exposure to organophosphorus compounds.
[Effects of Salvia miltiorrhiza Bunge on isolated perfused liver and portal vein of rats]. (1992)

The experiment results showed that Salvia miltiorrhiza (SMB) had a protective effect on the isolated perfused liver injured by CCl4 of rats, made the activity of GPT in perfusate of SMB group lower than that of intoxicated groups and relieved the hepato-pathohistologic lesions of SMB group as compared to the intoxicated group. SMB had no significant effects on both the activities of SGPT in vitro and the portal vein of rats.
Different Mutant/Wild-Type p53 Combinations Cause a Spectrum of Increased Invasive Potential in Nonmalignant Immortalized Human Mammary Epithelial Cells (2008)

Aberrations of p53 occur in most, if not all, human cancers. In breast cancer, p53 mutation is the most common genetic defect related to a single gene. Immortalized human mammary epithelial cells resemble the earliest forms of aberrant breast tissue growth but do not express many malignancy-associated phenotypes. We created a model of human mammary epithelial tumorigenesis by infecting hTERT-HME1 immortalized human mammary epithelial cells expressing wild-type p53 with four different mutant p53 constructs to determine the role of p53 mutation on the evolution of tumor phenotypes. We demonstrate that different mutant/wild-type p53 heterozygous models generate loss of function, dominant negative activity, and a spectrum of gain of function activities that induce varying degrees of invasive potential. We suggest that this model can be used to elucidate changes that occur in early stages of human mammary epithelial tumorigenesis. These changes may constitute novel biomarkers or reveal novel treatment modalities that could inhibit progression from primary to metastatic breast disease.
Managing Extended Producer Responsibility using PLM Part 2: Identification of Joints for End-of-life Treatment Planning (2008)

Computer-Aided Design and Applications is an international journal on the applications of CAD and CAM. It publishes papers in the general domain of CAD plus in emerging fields like bio-CAD, nano-CAD, soft-CAD, garment-CAD, PLM, PDM, CAD data mining, CAD and the internet, CAD education, genetic algorithms and CAD engines. The journal is aimed at all developers and users of CAD technology to ptovide CAD solutions for various stages of design and manufacturing. The journal publishes all about Computer-Aided Design and Computer-Aided technologies.
Hemicellulose‐degrading bacteria and yeasts from the termite gut (1996)

Termites play a major role in the recycling of photosynthetically fixed carbon. With the aid of their symbiotic intestinal flora, they are able to degrade extensively wood constituents such as cellulose and hemicellulose. Nevertheless, the microbial species involved in the degradation of hemicelluloses are poorly defined. The purpose of this paper was to examine the microflora involved in hemicellulose degradation. Different aerobic and facultatively anaerobic bacteria and yeasts were isolated using xylan, arabinogalactan and carboxymethylcellulose as substrates. Gram-positive isolates belonged to the genera Bacillus, Paenibacillus, Streptomyces or the actinobacteria group, while the Gram-negative strains were assigned to the genera Pseudomonas, Acinetobacter, Ochrobactrum, and to genera belonging to the family Enterobacteriaceae. The spectrum and activity of xylan- and arabinogalactan-hydrolysing glycosidases of these new isolates, together with additional bacterial strains originally obtained from enrichments with aromatic compounds were determined.
Determination of Human Papillomavirus (HPV) Load and Type in High-Grade Cervical Lesions Surgically Resected from HIV-Infected Women during Follow-up of HPV Infection (2005)

The significantly higher HPV load detected in women with high-grade cervical dysplasia, as well as the dramatic decrease in the load after surgical removal of the lesion, suggest that HPV load is a possible prognostic marker of high-grade SIL.
Universal prestorage leukoreduction in Canada decreases platelet alloimmunization and refractoriness (2003)

Abstract Randomized controlled trials have shown a reduction in platelet alloimmunization and refractoriness in patients with acute leukemia (AL) with the use of poststorage leukoreduction of blood products. Universal prestorage leukoreduction (ULR) of red cell and platelet products has been performed in Canada since August 1999. We conducted a retrospective analysis of 13 902 platelet transfusions in 617 patients undergoing chemotherapy (CT) for AL or stem cell transplantation (SCT) before (n = 315) and after (n = 302) the introduction of ULR. Alloimmunization was significantly reduced (19% to 7%, P &lt; .001) in the post-ULR group. Alloimmune platelet refractoriness was similarly reduced (14% to 4%, P &lt; .001). Fewer patients in the post-ULR group received HLA-matched platelets (14% vs 5%, P &lt; .001). Alloimmunization and alloimmune refractoriness in the 318 patients who were previously pregnant and/or transfused were also reduced after ULR (P = .023 and P = .005, respectively). In a Cox regression model, the 3 independent factors that predicted for alloimmune refractoriness were nonleukoreduced blood products (relative risk [RR], 2.2 [95% CI, 1.2-4.3]), a history of pregnancy and/or transfusion (RR, 2.3 [95% CI, 1.3-4.2]), and receipt of 13 or more platelet transfusions (RR, 6.0 [95% CI, 2.4-15.3]). In conclusion, ULR reduces alloimmunization, refractoriness, and requirements for HLA-matched platelets when applied as routine transfusion practice to patients receiving CT or SCT.
Olefin Metathesis in the Design and Synthesis of a Globally Constrained Grb2 SH2 Domain Inhibitor (2001)

One drawback frequently associated with olefin metathesis-mediated peptide macrocyclization, the loss of side chain functionality at sites of ring closure, may be circumvented by incorporation of side chain functionality within the ring-closing olefin segments. This approach is demonstrated in the preparation of a macrocyclic Grb2 SH2 domain antagonist designed as a conformationally constrained beta-bend mimic.
Enhancing Performance of VoIP over HSDPA (2007)

This paper presents a study of packet scheduling enhancements for VoIP service over high-speed downlink packet access (HSDPA) in WCDMA. Taking VoIP traffic characteristics into account in Node B packet scheduling algorithm is a key element in achieving good performance and high VoIP capacity. The novelty of this study consists of dynamic transmission resource allocation method for VoIP service. Dynamic resource allocation takes the estimated channel conditions and the transmission requirements of a user into account to increase the efficiency of resource utilization. Simulation results produced with a dynamic system simulator indicate 20 % VoIP capacity gain achieved with the proposed enhancement when compared to the conventional even share resource allocation.
<title>Layered Synthetic Microstructures: Properties And Applications In X-Ray Astronomy</title> (1979)

Improvements in vacuum deposition technology have made it possible to produce structures in whichotwo materials are arranged in alternating layers of uniform thickness. These layers may be as thin as 5A. Such structures act as Bragg diffractors or "artificial crystals" for x-rays - alternatively they may be viewed as multilayer interference coatings. These devices have many potential applications in x-ray and euv astronomy. Through the use of a dynamical theory, we show how the properties of LSM's depend on the layer materials and thicknesses and how these properties may be "tailored" for specific applications. Laboratory results at various x-ray wavelengths are presented. Finally, specific x-ray astronomy applications in the areas of spectroscopy, imaging, polarimetry and laboratory calibration are discussed.
Measuring engagement effectiveness in social media (2012)

Social media is becoming increasingly prevalent with the advent of web 2.0 technologies. Popular social media websites, such as Twitter and Facebook, are attracting a gigantic number of online users to post and share information. An interesting phenomenon under this trend involves that more and more users share their experiences or issues with regard to a product, and then the product service agents use commercial social media listening and engagement tools (e.g. Radian6, Sysomos, etc.) to response to users' complaints or issues and help them tackle their problems. This is often called customer care in social media or social customer relationship management (CRM). However, all these existing commercial social media tools only provide an aggregated level of trends, patterns and sentiment analysis based on the keyword-centric brand relevant data, which have little insights for answering one of the key questions in social CRM system: how effective is our social customer care engagement? In this paper, we focus on addressing the problem of how to measure the effectiveness of engagement for service agents in customer care. Traditional CRM effectiveness measurements are defined under the scenario of the call center, where the effectiveness is mostly based on the duration time per call and/or number of answered calls per day. Different from customer care in a call center, we can obtain detailed conversations between agents and customers in social media, and therefore the effectiveness can be measured by analyzing the content of conversations and the sentiment of customers.
UV Absorption Spectra of Adlayers of Trimethylgallium and Arsine (1989)

The UV absorption spectra of trimethylgallium (TMG) and arsine adsorbed on silica were investigated. The spectrum of the physisorbed layers of TMG and arsine were similar to the corresponding vapor spectra. On the other hand, the spectrum of the chemisorbed TMG layer was quite different. from that of vapor. Arsine can be chemisorbed on the chemisorbed TMG layer, although it cannot be chemisorbed on silica. The spectrum of the co-chemisorbed layer, consisting of TMG and arsine, was found to extend greatly to longer wavelengths.
Inferring clinical depression from speech and spoken utterances (2014)

In this paper, we investigate the problem of detecting depression from recordings of subjects' speech using speech processing and machine learning. There has been considerable interest in this problem in recent years due to the potential for developing objective assessments from real-world behaviors, which may provide valuable supplementary clinical information or may be useful in screening. The cues for depression may be present in "what is said" (content) and "how it is said" (prosody). Given the limited amounts of text data, even in this relatively large study, it is difficult to employ standard method of learning models from n-gram features. Instead, we learn models using word representations in an alternative feature space of valence and arousal. This is akin to embedding words into a real vector space albeit with manual ratings instead of those learned with deep neural networks [1]. For extracting prosody, we employ standard feature extractors such as those implemented in <i>openSMILE</i> and compare them with features extracted from harmonic models that we have been developing in recent years. Our experiments show that our features from harmonic model improve the performance of detecting depression from spoken utterances than other alternatives. The context features provide additional improvements to achieve an accuracy of about 74%, sufficient to be useful in screening applications.
Analysis of Half-Quadratic Minimization Methods for Signal and Image Recovery (2005)

We address the minimization of regularized convex cost functions which are customarily used for edge-preserving restoration and reconstruction of signals and images. In order to accelerate computation, the multiplicative and the additive half-quadratic reformulation of the original cost-function have been pioneered in Geman and Reynolds [IEEE Trans. Pattern Anal. Machine Intelligence, 14 (1992), pp. 367--383] and Geman and Yang IEEE Trans. Image Process., 4 (1995), pp. 932--946]. The alternate minimization of the resultant (augmented) cost-functions has a simple explicit form. The goal of this paper is to provide a systematic analysis of the convergence rate achieved by these methods. For the multiplicative and additive half-quadratic regularizations, we determine their upper bounds for their root-convergence factors. The bound for the multiplicative form is seen to be always smaller than the bound for the additive form. Experiments show that the number of iterations required for convergence for the multiplicative form is always less than that for the additive form. However, the computational cost of each iteration is much higher for the multiplicative form than for the additive form. The global assessment is that minimization using the additive form of half-quadratic regularization is faster than using the multiplicative form. When the additive form is applicable, it is hence recommended. Extensive experiments demonstrate that in our MATLAB implementation, both methods are substantially faster (in terms of computational times) than the standard MATLAB Optimization Toolbox routines used in our comparison study.
Improved data transfer scheduling and optimization as a service in cloud (2016)

Upgrading information exchange of extensive information sets is still a major test in distributed computing. Viable use of accessible system transfer speed has turned out to be progressively critical for wide region information development. We have studied few concepts like pipelining, parallelism, concurrency and application level throughput optimization for optimal data transfer movement. We propose to implement improved data transfer scheduling and optimization in cloud. It includes the modules, namely module chaining, Data parking and Adaptive scheduling. Module chaining will permit exchange for application level created information by utilizing one exchange module to recover information and at the same time utilizing another module to send information, Data parking will permit exchanges that may fall flat just at accepting end to be continued without having so as to require further contact with sending end cloud store documents until the less than desirable end gets to be dynamic again and an Adaptive scheduling calculation which predicts the best parameters for record exchange and set the level of parallelism and pipelining for information exchange operations as per the application level throughput of past and current operations inside the scheduler.
An All-Digital, $V$ <sub>MAX</sub>-Compliant, and Stable Distributed Charge Injection Scheme for Fast Mitigation of Voltage Droop (2019)

Distributed charge injection (CI) scheme featuring distributed V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">MAX</sub> -complaint CI clamps, distributed digital droop detectors (DDDs), and distributed droop controllers for fast mitigation of voltage droop is fabricated in 10-nm FinFET CMOS test-chip. A local DDD detects nearby voltage droop in two clock cycles of IP block, and quickly triggers associated CI clamps to inject charge from a high voltage rail (e.g., 1.8 V) to V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">CC</sub> for immediate voltage droop mitigation. Local droop controller collectively guarantees stable operation after CI is triggered, by gradually allowing the voltage regulator to take over after the droop subsides. Measured data shows droop reduction by up to 45% for a uniform transient load current transition, and by 38% in a hot-spot load current transition at 1.0 V and 2.0 GHz. The droop reduction is translated to power savings of ~11% over a guard-banded baseline.