gebhart/patrepeval huggingface dataset:
Seizure onset detection based on a Uni- or Multi-modal Intelligent Seizure Acquisition (UISA/MISA) system (2010)

An automatic Uni- or Multi-modal Intelligent Seizure Acquisition (UISA/MISA) system is highly applicable for onset detection of epileptic seizures based on motion data. The modalities used are surface electromyography (sEMG), acceleration (ACC) and angular velocity (ANG). The new proposed automatic algorithm on motion data is extracting features as "log-sum" measures of discrete wavelet components. Classification into the two groups "seizure" versus "non-seizure" is made based on the support vector machine (SVM) algorithm. The algorithm performs with a sensitivity of 91-100%, a median latency of 1 second and a specificity of 100% on multi-modal data from five healthy subjects simulating seizures. The uni-modal algorithm based on sEMG data from the subjects and patients performs satisfactorily in some cases. As expected, our results clearly show superiority of the multi-modal approach, as compared with the uni-modal one.
Simple <i>piggyBac</i> transposon-based mammalian cell expression system for inducible protein production (2013)

Reported here is a piggyBac transposon-based expression system for the generation of doxycycline-inducible, stably transfected mammalian cell cultures for large-scale protein production. The system works with commonly used adherent and suspension-adapted mammalian cell lines and requires only a single transfection step. Moreover, the high uniform expression levels observed among clones allow for the use of stable bulk cell cultures, thereby eliminating time-consuming cloning steps. Under continuous doxycycline induction, protein expression levels have been shown to be stable for at least 2 mo in the absence of drug selection. The high efficiency of the system also allows for the generation of stable bulk cell cultures in 96-well format, a capability leading to the possibility of generating stable cell cultures for entire families of membrane or secreted proteins. Finally, we demonstrate the utility of the system through the large-scale production (140-750 mg scale) of an endoplasmic reticulum-resident fucosyltransferase and two potential anticancer protein therapeutic agents.
Preparation and in vitro characterization of slow release testosterone nanocapsules in alginates. (2006)

Slow release testosterone-loaded nanocapsules in alginate, biodegradable hydropolymer, were prepared by in situ nanoemulsion-polymer crosslinking approach. Different formulations varying in the drug loading solvent phase were prepared. Four different drug-loading solvents were assayed and the food grade hexane provided nanocapsules testosterone load of 30%. Testosterone loading was confirmed by FT-IR, DSC and quantitated by HPLC. Prepared nanocapsules appeared spherical with a dense drug core in transmission electron microscopy studies. Hydrodynamic diameter of nanocapsules was 34.5 +/- 1.7 nm, with a Gaussian distribution and the zeta potential -5.0 meV. Sustained diffusive drug release was observed in vitro, following zero order kinetics releasing the drug payload over a period of 48 hours. Embedding testosterone in alginate provided sustained release. Different drug loading solvents have distinct influence on drug loading and nanocapsules size distribution. The nanocapsulation technique developed can be a good choice for the development of different sustained steroid hormonal drug carriers.
[η <sup>4</sup> ‐1,5‐Cyclooctadiene)(Pyridine)‐(Tricyclohexylphosphine)Iridium(I)Hexafluorophosphate (1986)

This chapter contains sections titled: (η41,5-Cyclooctadiene)bis(pyridine)iridium(I) Hexafluorophosphate (η41,5-Cyclooctadiene)(pyridine)(tricyclohexylphosphine)-iridium(I) Hexafluorophosphate
Layered double hydroxide nanomaterials as potential cellular drug delivery agents (2006)

Abstract This paper briefly reviews the recent progress in using layered double hydroxide (LDH) nanomaterials as cellular delivery agents. The advantages of LDHs as cellular delivery agents are summarized, and the processes of interaction/de-intercalation of anionic drugs (genes) into/from LDH nanoparticles are discussed. Then the cellular delivery of LDH-drug (gene) nanohybrids and subsequent intracellular processes are presumably proposed. At the end, some challenges and remarks for efficient delivery of drugs (genes) via LDH nanoparticles are provided to the best of our knowledge.
A novel class of nonionic microemulsions: fluorocarbons in aqueous solutions of fluorinated poly(oxyethylene) surfactants (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA novel class of nonionic microemulsions: fluorocarbons in aqueous solutions of fluorinated poly(oxyethylene) surfactantsGerard Mathis, Patrick Leempoel, Jean Claude Ravey, Claude Selve, and Jean Jacques DelpuechCite this: J. Am. Chem. Soc. 1984, 106, 21, 6162–6171Publication Date (Print):October 1, 1984Publication History Published online1 May 2002Published inissue 1 October 1984https://doi.org/10.1021/ja00333a007RIGHTS & PERMISSIONSArticle Views372Altmetric-Citations93LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alerts Get e-Alerts
New mutation to Huntington's disease. (1989)

We report a large family with an isolated case of Huntington's disease (HD), which is probably the result of a new mutation. The patient developed clinical signs typical of HD at the age of 36. The clinical course of the patient's disease is documented by several clinical admissions over a period of 14 years at present. The family history is strikingly negative with the parents having been clearly unaffected into their 80s and with 13 older and two younger, living, healthy sibs. Extensive testing of polymorphic markers (blood groups, red cell and serum proteins, HLA antigens) showed no indication of non-paternity, but rather gave strong support to the hypothesis that the proband is a full sib. In addition, DNA typing for several RFLPs known to be closely linked to the HD gene locus indicated that several clearly unaffected sibs share one or the other or both of the patient's haplotypes. This is further evidence in favour of the hypothesis of a new mutation at the HD locus. The posterior probability of a new mutation to HD in the patient exceeds 99%, even if an a priori probability of non-paternity of 10% and a mutation rate of HD of 10(-7) is assumed.
A batch reactor mass transfer kinetic model for immobilized biomass biosorption (1988)

Inactive cells of Rhizopus arrhizus have been immobilized into the form of particles of desirable particle size using a proprietary immobilization technique. The immobilized biomass particles are porous and are members of a new generation of biological origin adsorbents. The uranium adsorptive behavior of the biosorbent particles was modeled using a batch reactor mass transfer kinetic model of the biosorption process. The model successfully predicts the batch reactor adsorbate (uranium) concentration profiles and has provided significant insights on the way biosorbents function.
Effect of mixing on the rheological characteristics of conditioned sludge: full-scale studies (1997)

Conditioning of wastewater sludges with polyelectrolytes prior to dewatering is necessary to increase the sludges' dewaterability. During this conditioning process adequate mixing of the conditioner and the sludge must be attained. This research reports on results from full-scale experiments conducted to examine the effect of mixing parameters upon the conditioned sludge and liquid stream rheological characteristics. Full-scale experiments were conducted at the 90 MGD Wilmington Pollution Control Facility. Varied mixing conditions were the rotational speed of the flocculation tank prior to dewatering and the filtrate recycling to the flocculation tank. The rheological changes in the conditioned sludge were detected using an on-line ZenoFloc™ system. Although previous investigations have shown effects of such variations with regard to CST, use of a rheometer as indication of the rheological changes also showed that G variations led to different rheological levels. This allows some insight into conditioning mechanisms as well as optimization. Results also showed that mixing must be optimized and controlled for better dewatering performance.
Domains in Thin Magnetic Films Observed by Electron Microscopy (1960)

A new method for observing full domains in thin magnetic films by electron microscopy is described. Observations are made with standard transmission instruments utilizing an off-centered objective aperture diaphragm as a knife edge. The method has the high-resolution advantage that the microscope is focused on the specimen during domain observations. Limitations of the method and comparisons with the previously reported defocusing technique are presented. Applications to the interpretation of complex domain patterns and cross-tie walls are demonstrated. The observations were made with electrostatic-focusing microscopes, the AEG-Zeiss and Trüb-Täuber instruments, which allow the use of full objective power without influencing the magnetization distribution of low coercive force films. A second method using a knife edge is proposed that would potentially permit a simple measurement of the detailed magnetization distribution of a domain wall in a thin film.
R peak detection in electrocardiogram signal based on a combination between empirical mode decomposition and Hilbert transform (2014)

In this paper, we present a combination between Empirical Mode Decomposition (EMD) approach and Hilbert transform approach for the purpose of R peak detection in Electrocardiogram (ECG) signal. This algorithm uses the EMD to find the signal which highlights the region of the QRS complex in ECG signal by combining the first three IMF that contain sufficient information about the region of the QRS complex then the envelope obtained from Hilbert transform to detect the R-peaks. The proposed method requires the following stages: eliminate the baseline wander from the original ECG signal, decompose the resulting filtered ECG signal into a collection of AM-FM components called Intrinsic Mode Functions (IMF) which are obtained by using Empirical Mode Decomposition approach, sum the first three Intrinsic Functions Mode (IMFs) which contain enough information about the QRS complex, calculate the first derivative of the sum signal to get the points of minima or maxima, The differentiated signal is then transformed using Hilbert transform and then we determine the Hilbert envelope, and finally, find the positions of the maximum which represent the positions of the R peaks. The proposed algorithm is evaluated by using the ECG MIT-BIH database and is compared to another technique, proposed by Taouili. The performance of the algorithm is confirmed by a sensitivity of 94.71 %, compared to Se=91.17 given by Taouli's method.
Overview of Chemically Vapor Deposited (CVD) Polymers (2015)

Chemical vapor deposition (CVD) polymer films can be applied to nearly any substrate. For the highest quality polymer films, CVD is the method of choice, even for layers that can be formed by other means. Durability is paramount in the majority of applications for polymeric coatings. The formation of insoluble crosslinked organic networks by CVD is one synthesis strategy for achieving durability. In many cases, CVD polymerization methods represent the direct translation of solution phase organic synthesis methods into heterogeneous processes for surface modification. The initiated CVD (iCVD) is a versatile method for synthesizing chain growth polymers. The oxidative chemical vapor deposition (oCVD) method enables the step growth of conjugated polymers that are typically either semiconductors or electrical conductors. Both vapor deposition polymerization (VDP) and molecular layer deposition (MLD) are useful for step growth polymers synthesized through condensation reactions.
Automated Sample Preparation for Monitoring Groundwater Pollution by Carbamate Insecticides and Their Transformation Products (1995)

We investigated automated on-line solid-phase extraction (SPE) followed by liquid chromatographic (LC) techniques for monitoring carbamates and their transformation products. Analytical determinations were performed by LC with UV or postcolumn fluorescence detection (U.S. Environmental Protection Agency Method 531.1 for carbamate insecticides) after preconcentration with on-line SPE using C18 Empore extraction disks. On-line SPE/LC/thermospray mass spectrometry with time-scheduled selected-ion monitoring was used as confirmatory method. The method was used to determine pesticide traces in well waters of a typical aquifer in the Almeria area (Andalucia, south of Spain) from March 1993 to February 1994. The major pollutants, found in highest amounts, were carbofuran, methiocarb, and methomyl, at levels of 0.32, 0.3, and 0.8 micrograms/L, respectively. According to results of seasonal variation studies, pollution by carbamate insecticides is sporadic and exceeds the limit of 0.5 micrograms/L for total pesticides allowed by the European Economic Community Drinking Water Directive only twice a year. 3-Hydroxycarbofuran and methiocarb sulfone also were detected, showing the importance of including the main toxic break-down products of carbamate insecticides in future monitoring programs.
Melt Electrospinning and Its Technologization in Tissue Engineering (2014)

Melt electrospinning is an emerging fiber-based manufacturing technique that can be used to design and build scaffolds suitable for many tissue engineering (TE) applications. Contrary to the widely used solution electrospinning, the melt process is solvent-free and therefore volatility and toxicity issues associated with solvents can be avoided. Furthermore, molten polymers are often viscous and nonconductive, making them candidates for generating electrospinning jets without electrical instabilities. This in turn permits a precise and predictable fiber deposition in the combination with moving collectors, termed melt electrospinning writing (MEW), allows the layer-by-layer fabrication of small to large volume scaffolds with specific designs, shapes and thicknesses. In vitro studies have demonstrated that scaffolds designed and fabricated via MEW can support cell attachment, proliferation and extracellular matrix formation, as well as cell infiltration throughout the thickness of the scaffold facilitated by the large pores and pore interconnectivity. Moreover, in vivo studies show that scaffolds designed for specific tissue regeneration strategies performed superbly. This review describes the state-of-the-art and unique perspectives of melt electrospinning and its writing applied to scaffold-based TE.
Imported cutaneous leishmaniasis: a 13-year experience of a Polish tertiary center (2019)

Intensified education of physicians and travelers, as well as improvement in the access to travel medicine services and to the diagnosis and treatment methods appropriate for CL, are needed in our country. In our opinion, surveillance of leishmaniasis should be introduced in Poland.
Swarm Intelligence Based Technique for Rule Mining in the Medical Domain (2010)

In this paper, we present a swarm intelligence based technique for mining rules over a medical database. Rules are a suitable method for representing real world medical knowledge because of their simplicity, uniformity, transparency, and ease of inference. Swarm Intelligence (SI) has been applied to the rule mining process as its dynamic nature provides flexibility and robustness to process of rule mining. Traditional methods of rule mining generate a large number of rules with too many terms, making the system unusable over medical data. In this paper, the attempt is to use SI as a novel method for discovering interesting rules in the medical domain. The performance of three different swarm based techniques has been compared by observing the output rules of rule sets used to classify data. Section 1 introduces the concept of swarm intelligence and rule mining and how these can be combined. Issues that arise in mining medical data are also briefly listed. Section 2 describes conventional rule mining techniques and states the motivation behind using swarm intelligence for rule mining and classification. Section 3 describes the various SI based algorithms that have been implemented in our study. Section 4 describes the details of the experiment. Section 5 presents the results of the practical experiment followed by conclusions and future scope in section 6.
Carrier components assignment method for LTE and LTE-A systems based on user profile and application (2014)

Increasing number of mobile users accesses large multimedia files (such as high definition audio, video, images, etc.) over the Internet. Therefore, the bandwidth demand for mobile Internet access is getting exponentially larger. To answer users' demand, Carrier Aggregation is proposed in LTE-A. In Carrier Aggregation, multi bands are used and the bands have supported different coverage. Therefore, mobile users can simultaneously connect only one or multi bands. Because of mobility of users, traffic types and assigned channel errors, the best available Carrier Components of each band should be assigned to each user in order to increase quality of services. Several works have been proposed in the literature to address Carrier Components assignment to mobile users by using Channel Quality Indicator, quality of service and traffic types in LTE systems. However, continuously increasing data requests of users forces the operators to manage traffic more intelligently. Therefore, we have proposed a novel Carrier Component assignment method which considers user profiles and traffic types to increase quality of services and experiences getting by mobile users. Results show that the proposed method uses system resources efficiently and can provide improved throughput rate in LTE and LTE-A systems. Our method will help service providers build efficient Carrier Component assignment services through considering user profile and traffic types.
Workload-Driven VM Consolidation in Cloud Data Centers (2015)

Virtual machines hosted in virtualized data centers are important providers of computational resources in the era of cloud computing. Efficient scheduling of data centers' virtual machines can reduce the number of physical servers needed to host the virtual machines and, in turn, reduce the energy and other capital costs for maintaining the virtualized data centre. In this paper, we propose an innovative approach to achieve efficient pro-active VM scheduling. Our approach uses a multi-capacity bin packing technique that efficiently places VMs onto physical servers. We use time-series analysis techniques to extract not only low frequency information about future VM workloads but also high frequency information for VM workload correlations. We show that the proposed algorithms mathematically guarantee the VM scheduling meets the Service Level Objectives (SLO) and, moreover, guarantee statistically that the desired success probability of the SLO is met. Evaluation of our technique on production (real) workloads shows that our approach reduces by up to 15% the number of physical machines. We also see improvements of up to 18% for production workloads in machine utilization.
The Primary Structure of the Inhibitor of Tissue Plasminogen Activator Found in the Seeds of Erythrina caffra (1987)

Trypsin and tissue plasminogen activator inhibitor DE-3 from Erythrina caffra contains 172 amino acids, including 4 half-cystine residues, and resembles the Kunitz-type inhibitors. Limited hydrolysis of DE-3 with trypsin at pH 3.2 produced two fragments, F1 and F2, containing 63 and 109 amino acids, respectively. Amino-terminal sequence studies showed that F1 was the N-terminal and that F2 was the C-terminal fragment. The complete amino acid sequence of the fragments were then determined on peptides produced by enzymatic digestion with trypsin. The sequence of trypsin and tissue plasminogen activator inhibitor DE-3 from E. caffra seeds shows a high degree of homology to that of trypsin and tissue plasminogen activator inhibitor DE-3 from E. latissima seeds and revealed only four amino acids which were replaced.
Computational Investigation on the Photoacoustics of Malaria Infected Red Blood Cells (2012)

A computer simulation study on the possibility of using photoacoustic (PA) technique to differentiate intraerythrocytic stages of malarial parasite is reported. This parasite during its development substantially converts hemoglobin into hemozoin. This conversion is expected to alter the cellular absorption leading to changes in the PA emission of a red blood cell (RBC) at certain incident optical wavelengths. The PA signals from blood samples corresponding to ring, trophozoite and schizont stages were computed and compared with that of normal blood. A Monte Carlo algorithm was implemented generating random locations of RBCs in 3D to simulate blood samples. The average PA amplitude for wide bandwidth signals decreases for 434 nm incident radiation, but increases for 700 nm as the parasite matures. The spectral power at 7.5 MHz for the blood sample at the schizont stage compared to the normal blood is nearly reduced by 6 dB and enhanced by 22 dB at those incident wavelengths, respectively. Bandlimited signals for transducers of 15 and 50 MHz center frequencies were studied and found to exhibit similar characteristics. The presence of hemozoin inside the cells was examined and an excellent estimation was made. The simulation results suggest that intraerythrocytic stages of malarial parasite may be assessed using the PA technique.
Distinct domains of M-T2, the myxoma virus tumor necrosis factor (TNF) receptor homolog, mediate extracellular TNF binding and intracellular apoptosis inhibition (1997)

The myxoma virus tumor necrosis factor (TNF) receptor homolog, M-T2, is expressed both as a secreted glycoprotein that inhibits the cytolytic activity of rabbit TNF-alpha and as an endoglycosidase H-sensitive intracellular species that prevents myxoma virus-infected CD4+ T lymphocytes from undergoing apoptosis. To compare the domains of M-T2 mediating extracellular TNF inhibition and intracellular apoptosis inhibition, recombinant myxoma viruses expressing nested C-terminal truncations of M-T2 protein were constructed. One mutant, deltaL113, containing intact copies of only two cysteine-rich domains, was not secreted and was incapable of binding rabbit TNF-alpha yet retained full ability to inhibit virus-induced apoptosis of RL-5 cells. Thus, the minimal domain of intracellular M-T2 protein required to inhibit apoptosis is distinct from that required by the extracellular M-T2 for functional TNF-alpha binding and inhibition. This is the first report of a virus-encoded immunomodular protein with two distinct antiimmune properties.