gebhart/patrepeval huggingface dataset:
Immunomodulating potential of supplementation with probiotics: a doseâresponse study in healthy young adults (2006)

Certain probiotic microorganisms have been found beneficial in the treatment of immune-related diseases and may also affect immune function in healthy people. Intervention studies of probiotics in healthy humans are urgently required. Here, the immunomodulating potential of Bifidobacterium animalis ssp. lactis (BB-12) and Lactobacillus paracasei ssp. paracasei (CRL-431) was studied in a double-blind placebo-controlled parallel dose-response trial (n=71) based on five randomly assigned groups of young healthy adults supplemented for 3 weeks with 0, 10(8), 10(9), 10(10) and 10(11) CFU day(-1), respectively, of a mixture of BB-12 and CRL-431. No statistically significant dose-dependent effect was found for phagocytic activity in blood leukocytes, fecal immunoglobulin A (IgA) concentrations or production of interferon-gamma and interleukin-10 in blood cells. When evaluating data according to the amount of viable BB-12 recovered from faeces, the interferon-gamma production in blood cells was significantly reduced. In conclusion, no solid effect on the immune function of young healthy adults supplemented with even high doses of B. animalis ssp. lactis BB-12 and L. paracasei ssp. paracasei CRL-431 was demonstrated in this study.
Introduction to Dynamics of Rotor-Bearing Systems (2007)

This book is written as an introduction to rotor-bearing dynamics for practicing engineers and students who are involved in rotordynamics and bearing design. The goal of this book is to In this system figure out to the path. Hunting is the question remains unanswered how opposite direction as inputs are thus. Seems strange doesn't it oscillates as therefore the decision rule. Several particular system dynamics diagramming convention, move.
Using recurrent neural network models for early detection of heart failure onset (2016)

Deep learning models adapted to leverage temporal relations appear to improve performance of models for detection of incident heart failure with a short observation window of 12-18 months.
Recovery from complete heart block in diphtheria. (1949)

Six patients who recovered from complete heart block in diphtheria have been reported. Four of these had intraventricular conduction disturbances as well. All but one of these patients had massive glandular and periglandular edema of the neck: a bullneck. The shortest duration of the conduction disorders was two days. The longest was six weeks. Two of the patients who recovered showed evidence of both cardiac decompensation and peripheral vascular collapse. Three of the patients were digitalized without untoward effect and with prompt improvement in at least two of them. Four of the six patients developed peripheral paralyses during convalescence.
IGORR meets in Korea (1998)

Abstract The sixth meeting of the International Group on Research Reactors (IGORR 6) was held in Taejon, The Republic of Korea, from April 29–May 1, 1998. Attendance was excellent–over 100 participants from 17 countries. slightly higher than lGORR 5. The meeting was very well organized, and very graciously hosted, by the staff of the Korea Atomic Energy Research Institute (KAERI).
The structure of α(AlCrSi)–Cr4Si4Al13 (1953)

The crystal structure of the interrnetallie compound Cr4Si4Alls has been determined. The main framework of the structure is a network of linked tetrahedra of Cr, Si and AI atoms, the latter being in 4-coordination. The form of the first prominent Brfllouin zone of the structure suggests that Cr has a negative 'effective valency' in this compound, and electron counts indicate a small excess of electrons in the Cr atoms. Unusually short interatomic distances between Cr and AI, similar to those previously reported for M_n and AI in Mn3SiAIg, occur in the structure.
Evolution of virulence in epidemic community-associated methicillin-resistant <i>Staphylococcus aureus</i> (2009)

Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has recently emerged worldwide. The United States, in particular, is experiencing a serious epidemic of CA-MRSA that is almost entirely caused by an extraordinarily infectious strain named USA300. However, the molecular determinants underlying the pathogenic success of CA-MRSA are mostly unknown. To gain insight into the evolution of the exceptional potential of USA300 to cause disease, we compared the phylogeny and virulence of USA300 with that of closely related MRSA clones. We discovered that the sublineage from which USA300 evolved is characterized by a phenotype of high virulence that is clearly distinct from other MRSA strains. Namely, USA300 and its progenitor, USA500, had high virulence in animal infection models and the capacity to evade innate host defense mechanisms. Furthermore, our results indicate that increased virulence in the USA300/USA500 sublineage is attributable to differential expression of core genome-encoded virulence determinants, such as phenol-soluble modulins and alpha-toxin. Notably, the fact that the virulence phenotype of USA300 was already established in its progenitor indicates that acquisition of mobile genetic elements has played a limited role in the evolution of USA300 virulence and points to a possibly different role of those elements. Thus, our results highlight the importance of differential gene expression in the evolution of USA300 virulence. This finding calls for a profound revision of our notion about CA-MRSA pathogenesis at the molecular level and has important implications for design of therapeutics directed against CA-MRSA.
Some Kinetic and Regulatory Properties of the Pea Mitochondrial Pyruvate Dehydrogenase Complex (1987)

The pyruvate dehydrogenase complex was isolated, partially purified, and characterized from green pea (Pisum sativum L., cv Little Marvel) leaf mitochondria. The pH optimum for the overall reaction was 7.6. The divalent cation requirement was best satisfied by Mg(2+). Reaction velocity was maximal at 40 degrees C. Pyruvate was a better substrate than 2-oxo-butyrate; other 2-oxo-acids were not substrates. Michaelis constants for substrates were; pyruvate, 57 micromolar; NAD, 122 micromolar; Coenzyme-A, 5 micromolar; Mg(2+), 0.36 millimolar; Mg-thiamine pyrophosphate, 80 nanomolar. The products, NADH and acetyl-Coenzyme-A, were linear competitive inhibitors with respect to NAD and Coenzyme A. Inhibition constants were 18 and 10 micromolar, respectively. Glyoxylate inhibited complex activity only in the absence of thiol reagents. Glyoxylate inhibition was competitive with respect to pyruvate with an inhibition constant of 51 micromolar. Among mitochondrial metabolites examined as potential effectors, only ADP with an inhibition constant of 0.57 millimolar could be of physiological significance.
Blood Flow in End-to-Side Anastomoses (2008)

Blood flow in end-to-side autogenous or prosthetic graft anastomoses is of great interest to biomedical researchers because the biomechanical force profile engendered by blood flow disturbances at such geometric transitions is thought to play a significant role in vascular remodeling and graft failure. Thus, investigators have extensively studied anastomotic blood flow patterns in relation to graft failure with the objective of enabling the design of a more optimal graft anastomotic geometry. In contrast to arterial bifurcations, surgically created anastomoses can be modified to yield a flow environment that improves graft longevity. Understanding blood flow patterns at anastomotic junctions is a challenging problem because of the highly varying and complex three-dimensional nature of the geometry that is subjected to pulsatile and, occasionally, turbulent flow.
Minor histocompatibility antigens as targets for T-cell therapy after bone marrow transplantation (1998)

In allogeneic bone marrow transplantation, differences between donor and recipient at minor histocompatibility loci, which encode allelic proteins containing variant peptide sequences, may result in adverse immune reactions such as graft-versus-host disease (GVHD), or graft rejection, but also a beneficial graft versus leukemia (GVL) response. Some minor H antigens are restricted in their expression to hematopoietic cells, including leukemic progenitors, suggesting it may be possible to separate GVHD and GVL responses. The antigenic peptides for a few human minor H antigens have been identified, and efforts to identify the genes encoding minor H antigens are being pursued. These advances promise to provide a more detailed understanding of the immunobiology and pathogenesis of GVHD and GVL responses and opportunities to selectively augment T-cell responses that promote a GVL effect by adoptive immunotherapy with T-cell clones specific for defined minor H determinants.
A putative angiogenin receptor in angiogenin-responsive human endothelial cells (1997)

Angiogenin stimulates both [3H]thymidine incorporation and proliferation of human endothelial cells in sparse cultures. Under these conditions, a 170-kDa cell surface protein can be detected that binds angiogenin specifically. Angiogenin-stimulated cell growth is concentration-dependent and is completely inhibited by an anti-angiogenin monoclonal antibody, but not by a nonimmune control antibody. It is not affected by the nonangiogenic homolog, RNase A, nor by other angiogenic proteins, such as basic fibroblast growth factor and its antibody. Results suggest that under specific conditions, endothelial cells express an angiogenin receptor that may mediate angiogenin-stimulated DNA synthesis and proliferation and play an important role in angiogenin-induced angiogenesis.
Polymerizable hexacatenar liquid crystals containing a luminescent oligo( <i>p</i> -phenylenevinylene) core (2004)

Polymerizable hexacatenar mesogens containing a photo-active oligo(p-phenylenevinylene) core were successfully synthesized by replacing the traditional n-alkoxy tails on the molecules with polymerizable hydrocarbon tails containing terminal isoprenyl or 1,3-dienyl units. It was found that for this particular liquid crystal (LC) platform, the incorporation of conventional radical polymerizable groups such as acrylates in the tails was not conducive to the formation of thermotropic LC phases, presumably due to their polar nature. The resulting photoluminescent isoprenyl and 1,3-dienyl hexacatenar monomers were found to form columnar hexagonal phases at elevated temperatures (c. 45–75°C), as determined by powder X-ray diffraction. Unfortunately, photoinitiated radical polymerization studies revealed that the mesogens are susceptible to photodegradation in the LC state at elevated temperatures, resulting in the loss of both LC order and emission properties during photopolymerization. Thermally initiated radical polymerization in the absence of light, however, afforded effective crosslinking with retention of both LC order and the desired emission properties. The resulting crosslinked columnar hexagonal phases were found to exhibit emission maxima at nearly identical wavelengths, with comparable intensities relative to the unpolymerized starting materials. The effect of the different polymerizable groups on the mesogenic behaviour, polymerization characteristics, and emission properties of the hexacatenar compounds is presented.
ChemInform Abstract: IMPROVEMENTS IN ATMOSPHERE SINTERING OF TRANSPARENT PLZT CERAMICS (1973)

Abstract Ein verbessertes Sinterverfahren an der Atmosphäre zur Herstellung großer, transparenter PLZT‐Scheiben (PLZT: Piezoelektrika der Art Pb(Zr,Ti)O3) für elektrooptische Anwendungen wird beschrieben.
Basic guidelines for deploying Wireless Sensor Networks in agriculture (2012)

This paper provides basic guidelines for deploying Wireless Sensor Networks (WSNs) in Agriculture, and more specifically in applications requiring crop monitoring. Firstly, it reviews the main components that existing WSN applications use, namely node platforms, operating systems (OSs), power supply, etc. Based on these data, a generic guide is proposed discussing basic considerations for deploying WSNs in applications relevant to agriculture.
Mechanism-Based Inactivation of tRNA-Guanine Transglycosylase from Escherichia coli by 2-Amino-5-(fluoromethyl)pyrrolo[2,3-d]pyrimidin-4(3H)-one (1995)

In Escherichia coli, tRNA-guanine transglycosylase (TGT) catalyzes the incorporation of the queuine precursor preQ1 [2-amino-5-(aminomethyl)pyrrolo[2,3-d]pyrimidin-4(3H)-one] into tRNA. This precursor is further elaborated to queuine by two subsequent enzymic reactions [Slany, R. K., & Kersten, H. (1994) Biochimie 76, 1178-1182]. Our previous studies [Hoops, G. C., Townsend, L. B., & Garcia, G. A., (1995) Biochemistry (in press)] on a series of synthetic 5- and 6-substituted 2-aminopyrrolo[2,3-d]pyrimidin-4(3H) -ones have revealed that the E. coli TGT tolerates a wide diversity of substituents (isosteric, or nearly so, to the aminomethyl group of preQ1) at the 5 position. We report here that 2-amino-5-(fluoromethyl)pyrrolo[2,3-d]pyrimidin-4 (3H)-one (FMPP) inactivates TGT in a time- and concentration-dependent manner with k(inact) = 0.074 min-1 and KI = 136 microM. A competitive inhibitor (7-methyl-preQ1), with respect to preQ1, of TGT [Hoops, G.C., Townsend, L.B., & Garcia, G.A. (1995) Biochemistry (in press)] protects the enzyme from inactivation by FMPP. FMPP also acts as a competitive inhibitor (KI = 114 microM) of TGT under initial velocity conditions. The rate of fluoride release from FMPP is slightly faster (0.064 min-1) than the k(inact) (0.053 min-1) at 300 microM FMPP, consistent with fluoride release preceding inactivation. FMPP appears to partition between "normal" turnover (kcat = 0.461 min-1 and Km = 152 microM), inactivation, and an alternative processing to an unidentified, fluoride-released product.(ABSTRACT TRUNCATED AT 250 WORDS)
Alloreactive immune responses of transgenic mice expressing a foreign transplantation antigen in a soluble form. (1988)

Transfection of cells with the H-2Kk gene lacking the transmembrane and cytoplasmic segments resulted in secretion of the H-2Kk protein, as determined by immunoprecipitation with monoclonal anti-H-2Kk antibodies. Transgenic (H-2b X H-2d)F1 mice were established carrying integrated copies of the modified H-2Kk gene. Expression of the soluble H-2Kk antigen in the transgenic mice was demonstrated in cell supernatants of biosynthetically labeled splenic and thymic Con A blasts as well as bone marrow-derived macrophages. Soluble H-2Kk molecules were also present in the sera of the transgenic animals. No cell-surface expression of the H-2Kk antigen could be observed. In spite of the presence of the soluble H-2Kk molecules in the transgenic mice, the animals were able to generate H-2Kk-specific cytolytic T cells as well as antibody responses when stimulated with cell-surface-bound H-2Kk antigens. These responses were indistinguishable from those of the nontransgenic littermates. Possible explanations for the observed lack of tolerance are discussed.
Effects of poly(methyl methacrylate‐co‐<i>n</i>‐butyl acrylate) on the properties and processing behavior of poly(vinyl chloride) (1985)

Abstract Random copolymers of methyl methacrylate/ n ‐butyl acrylate with a BA content of 0–50% and M̄ v = 0.16–4.04 × 10 6 were synthesized and evaluated as a processing aid (PA) for poly(vinyl chloride) (PVC). Their effects on the processability and properties of PVC were investigated with respect to the composition, molecular weight, and the amount of the copolymer added. It was found that the fusion rate of PVC could be improved (i) by increasing the amount of the copolymer used, (ii) by increasing the butyl acrylate content in the copolymer, and (iii) by lowering the molecular weight of the copolymer. The effect of molecular weight, composition, and amount of copolymer on the ultimate mechanical properties of PVC was investigated. The presence of copolymer did not affect the impact strength. However, the tensile strength and elongation at break were improved, particularly at high temperature (125°C). It was also found that the “plate out” phenomenon of PVC could be significantly reduced in the presence of the processing aid.
Performance analysis of LMS adaptive prediction filters (1990)

The conditions required to implement real-time adaptive prediction filters that provide nearly optimal performance in realistic input conditions are delineated. The effects of signal bandwidth, input signal-to-noise ratio (SNR), noise correlation, and noise nonstationarity are explicitly considered. Analytical modeling, Monte Carlo simulations and experimental results obtained using a hardware implementation are utilized to provide performance bounds for specified input conditions. It is shown that there is a nonlinear degradation in the signal processing gain as a function of the input SNR that results from the statistical properties of the adaptive filter weights. The stochastic properties of the filter weights ensure that the performance of the adaptive filter is bounded by that of the optimal matched filter for known stationary input conditions.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Active-site modification of native and mutant forms of inosine 5′-monophosphate dehydrogenase from <i>Escherichia coli</i> K12 (1980)

IMP dehydrogenase of Escherichia coli was irreversibly inactivated by Cl-IMP (6-chloro-9-beta-d-ribofuranosylpurine 5'-phosphate, 6-chloropurine ribotide). The inactivation reaction showed saturation kinetics. 6-Chloropurine riboside did not inactivate the enzyme. Inactivation by Cl-IMP was retarded by ligands that bind at the IMP-binding site. Their effectiveness was IMP>XMP>GMP>>AMP. NAD(+) did not protect the enzyme from modification. Inactivation of IMP dehydrogenase was accompanied by a change in lambda(max.) of Cl-IMP from 263 to 290nm, indicating formation of a 6-alkylmercaptopurine nucleotide. The spectrum of 6-chloropurine riboside was not changed by IMP dehydrogenase. With excess Cl-IMP the increase in A(290) with time was first-order. Thus it appears that Cl-IMP reacts with only one species of thiol at the IMP-binding site of the enzyme: 2-3mol of Cl-IMP were bound per mol of IMP dehydrogenase tetramer. Of ten mutant enzymes from guaB strains, six reacted with Cl-IMP at a rate similar to that for the native enzyme. The interaction was retarded by IMP. None of the mutant enzymes reacted with 6-chloropurine riboside. 5,5'-Dithiobis-(2-nitrobenzoic acid), iodoacetate, iodoacetamide and methyl methanethiosulphonate also inactivated IMP dehydrogenase. Reduced glutathione re-activated the methanethiolated enzyme, and 2-mercaptoethanol re-activated the enzyme modified by Cl-IMP. IMP did not affect the rate of re-activation of methanethiolated enzyme. Protective modification indicates that Cl-IMP, methyl methanethiosulphonate and iodoacetamide react with the same thiol groups in the enzyme. This is also suggested by the low incorporation of iodo[(14)C]acetamide into Cl-IMP-modified enzyme. Hydrolysis of enzyme inactivated by iodo[(14)C]acetamide revealed radioactivity only in S-carboxymethylcysteine. The use of Cl-IMP as a probe for the IMP-binding site of enzymes from guaB mutants is discussed, together with the possible function of the essential thiol groups.
Performance of simple timing synchronization and DC-offset compensation schemes for a short-ranged Bluetooth network (2002)

This paper describes an adaptive timing synchronization scheme and DC-offset compensation technique for a short-ranged Bluetooth system. The synchronization scheme estimates the variance of the partial-band interference, which is utilized for the trigger threshold value of the inquiry scan and page scan states, while DC-offset compensation scheme is designed using the access codes which are known to each Bluetooth device. Numerical results show the proposed synchronization algorithm is robust to the partial-band noise interference and of low complexity. Also, the new DC-offset compensation method shows more reliable estimation ability of DC-offset than the existing method without extra hardware burdens.
Photoluminescence of Cu-doped CdTe and related stability issues in CdS/CdTe solar cells (2000)

We explore Cu electronic states in CdTe using photoluminescence as the main investigative method. Our results are consistent with some Cu atoms occupying substitutional positions on the Cd sublattice and with others forming Frenkel pairs of the type Cui+–VCd− involving an interstitial Cu and a Cd vacancy. In addition, we find that Cu-doped CdTe samples exhibit a significant “aging” behavior, attributable to the instability of Cu acceptor states as verified by our Hall measurements. The aging appears to be reversible by a 150–200 °C anneal. Our results are used to explain efficiency degradation of some CdTe solar-cell devices which use Cu for the formation of a backcontact.
Zur ambivalenten Reaktivität von α‐Acyloxycarbonsäurechloriden (1975)

Abstract Die Reaktionen der α‐Acyloxycarbonsäurechloride 1 mit Alkoholen, Phenolen, Thiolen, Acetophenonoxim, Dimethylcadmium und Diazomethan als nucleophilen Reaktionspartnern wurden präparativ und teilweise NMR‐spektroskopisch untersucht. Es bilden sich, stark abhängig von der Struktur der Säurechloride und den Reaktionsbedingungen, insbesondere dem Zusatz von Base, die normalen Acylderivate 3 und/oder die Ringtautomeren‐Derivate 2 mit 1,3‐Dioxolan‐4‐on‐Struktur. Qualitative kinetische Experimente und die Isolierung von 4‐Oxo‐1,3‐dioxolan‐2‐ylium‐Salzen stützen die Annahme, daß das Entstehen der Dioxolanonderivate durch eine unter Nachbargruppenbeteiligung der α‐Acyloxygruppe verlaufende S N 1‐Substitution der Säurechloride selbst verursacht ist, die in Anwesenheit von Pyridin durch Abfangen der Oxonium‐Zwischenstufe unterbunden wird. Die normale Acylierung über Acylpyridiniumsalze tritt dann in den Vordergrund. Besondere Gesichtspunkte der Reaktionsmechanismen aller Reaktionen werden diskutiert.
Severe Persistent Hyperinsulinemic Hypoglycemia due to a De Novo Glucokinase Mutation (2004)

Glucokinase (GK) is a glycolytic key enzyme that functions as a glucose sensor in the pancreatic beta-cell, where it governs glucose-stimulated insulin secretion (GSIS). Heterozygous inactivating mutations in the glucokinase gene (GCK) cause a mild form of diabetes (maturity-onset diabetes of the young [MODY]2), and activating mutations have been associated with a mild form of familial hyperinsulinemic hypoglycemia. We describe the first case of severe persistent hyperinsulinemic hypoglycemia due to a "de novo" mutation in GCK (Y214C). A baby girl presented with hypoglycemic seizures since the first postnatal day as well as with inappropriate hyperinsulinemia. Severe hypoglycemia persisted even after treatment with diazoxide and subtotal pancreatectomy, leading to irreversible brain damage. Pancreatic histology revealed abnormally large and hyperfunctional islets. The mutation is located in the putative allosteric activator domain of the protein. Functional studies of purified recombinant glutathionyl S-transferase fusion protein of GK-Y214C showed a sixfold increase in its affinity for glucose, a lowered cooperativity, and increased kcat. The relative activity index of GK-Y214C was 130, and the threshold for GSIS predicted by mathematical modeling was 0.8 mmol/l, compared with 5 mmol/l in the wild-type enzyme. In conclusion, we have identified a de novo GCK activating mutation that causes hyperinsulinemic hypoglycemia of exceptional severity. These findings demonstrate that the range of the clinical phenotype caused by GCK mutations varies from complete insulin deficiency to extreme hyperinsulinemia.