gebhart/patrepeval huggingface dataset:
Hormone Signaling Linked to Silkmoth Sex Pheromone Biosynthesis Involves Ca2+/Calmodulin-dependent Protein Kinase II-mediated Phosphorylation of the Insect PAT Family Protein Bombyx mori Lipid Storage Droplet Protein-1 (BmLsd1) (2011)

Species-specific sex pheromones released by female moths to attract conspecific male moths are synthesized de novo in the pheromone gland (PG) via the fatty acid biosynthetic pathway. This pathway is regulated by a neurohormone termed pheromone biosynthesis activating neuropeptide (PBAN), a 33-amino acid peptide that originates in the subesophageal ganglion. In the silkmoth, Bombyx mori, cytoplasmic lipid droplets, which store the sex pheromone (bombykol) precursor fatty acid, accumulate in PG cells. PBAN stimulates lipolysis of the stored lipid droplet triacylglycerols (TAGs) and releases the precursor for final modification. PBAN exerts its physiological function via the PG cell-surface PBAN receptor, a G protein-coupled receptor that belongs to the neuromedin U receptor family. The PBAN receptor-mediated signal is transmitted via a canonical store-operated channel activation pathway utilizing Gq-mediated phospholipase C activation (Hull, J. J., Kajigaya, R., Imai, K., and Matsumoto, S. (2007) Biosci. Biotechnol. Biochem. 71, 1993-2001; Hull, J. J., Lee, J. M., Kajigaya, R., and Matsumoto, S. (2009) J. Biol. Chem. 284, 31200-31213; Hull, J. J., Lee, J. M., and Matsumoto, S. (2010) Insect Mol. Biol. 19, 553-566). Little, however, is known about the molecular components regulating TAG lipolysis in PG cells. In the current study we found that PBAN signaling involves phosphorylation of an insect PAT family protein named B. mori lipid storage droplet protein-1 (BmLsd1) and that BmLsd1 plays an essential role in the TAG lipolysis associated with bombykol production. Unlike mammalian PAT family perilipins, however, BmLsd1 activation is dependent on phosphorylation by B. mori Ca(2+)/calmodulin-dependent protein kinase II rather than protein kinase A.
Purification and Characterization of Two Forms of Glutamine Synthetase from the Pedicel Region of Maize (<i>Zea mays</i> L.) Kernels (1989)

Maize (Zea mays L.) kernel pedicels, including vascular tis- sues, pedicel parenchyma, placento-chalazal tissue, and the sur- rounding pericarp, contained two forms of glutamine synthetase (EC 6.3.1.2), separable by anion exchange chromatography under mildly acidic conditions. The earlier-eluting activity (GSp,), but not the later-eluting activity (GSp2), was chromatographically distinct from the maize leaf and root glutamine synthetases. The level of GSp1 activity changed in a developmentally dependent manner while GSp2 activity was constitutive. GSpi and GSp2 exhibited distinct ratios of transferase to hydroxylamine-dependent synthe- tase activities (5 and 23, respectively), which did not change with kernel age. Purified pedicel glutamine synthetases had native relative molecular masses of 340,000, while the subunit relative molecular masses differed slightly at 38,900 and 40,500 for GSp1 and GSp2, respectively. Both GS forms required free Mg2+ with apparent Kms = 2.0 and 0.19 millimolar for GSp1 and GSp2, respec- tively. GSp1 had an apparent Km for glutamate of 35 millimolar and exhibited substrate inhibition at glutamate concentrations greater than 90 millimolar. In contrast, GSp2 exhibited simple Michaelis- Menten kinetics for glutamate with a Km value of 3.4 millimolar. Both isozymes exhibited positive cooperativity for ammonia, with S0.5 values of 100 and 45 micromolar, respectively. GSp, appears to be a unique, kernel-specific form of plant glutamine synthetase. Possible functions for the pedicel GS isozymes in kemel nitrogen metabolism are discussed.
A Class of Errorless Codes for Overloaded Synchronous Wireless and Optical CDMA Systems (2009)

In this paper, we introduce a new class of codes for overloaded synchronous wireless and optical code-division multiple-access (CDMA) systems which increases the number of users for fixed number of chips without introducing any errors. Equivalently, the chip rate can be reduced for a given number of users, which implies bandwidth reduction for downlink wireless systems. An upper bound for the maximum number of users for a given number of chips is derived. Also, lower and upper bounds for the sum channel capacity of a binary overloaded CDMA are derived that can predict the existence of such overloaded codes. We also propose a simplified maximum likelihood method for decoding these types of overloaded codes. Although a high percentage of the overloading factor degrades the system performance in noisy channels, simulation results show that this degradation is not significant. More importantly, for moderate values of <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">E</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">b</sub> /N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> (in the range of 6-10 dB) or higher, the proposed codes perform much better than the binary Welch bound equality sequences.
Real-Time Volume Rendering Visualization of Dual-Modality PET/CT Images With Interactive Fuzzy Thresholding Segmentation (2007)

Three-dimensional (3-D) visualization has become an essential part for imaging applications, including image-guided surgery, radiotherapy planning, and computer-aided diagnosis. In the visualization of dual-modality positron emission tomography and computed tomography (PET/CT), 3-D volume rendering is often limited to rendering of a single image volume and by high computational demand. Furthermore, incorporation of segmentation in volume rendering is usually restricted to visualizing the presegmented volumes of interest. In this paper, we investigated the integration of interactive segmentation into real-time volume rendering of dual-modality PET/CT images. We present and validate a fuzzy thresholding segmentation technique based on fuzzy cluster analysis, which allows interactive and real-time optimization of the segmentation results. This technique is then incorporated into a real-time multi-volume rendering of PET/CT images. Our method allows a real-time fusion and interchangeability of segmentation volume with PET or CT volumes, as well as the usual fusion of PET/CT volumes. Volume manipulations such as window level adjustments and lookup table can be applied to individual volumes, which are then fused together in real time as adjustments are made. We demonstrate the benefit of our method in integrating segmentation with volume rendering in its application to PET/CT images. Responsive frame rates are achieved by utilizing a texture-based volume rendering algorithm and the rapid transfer capability of the high-memory bandwidth available in low-cost graphic hardware.
Positioning mobile manipulators to perform constrained linear trajectories (2008)

For mobile manipulators envisioned in home environments a kitchen scenario provides a challenging testbed for numerous skills. Diverse manipulation actions are required, e.g. simple pick and place for moving objects and constrained motions for opening doors and drawers. The robot kinematics and link limits however are restrictive. Therefore especially a constrained trajectory will not be executable from arbitrary placements of the mobile manipulator. A two stage approach is presented to position a mobile manipulator to execute constrained linear trajectories as needed for opening drawers. In a first stage, a representation of a robot armpsilas reachable workspace is computed. Pattern recognition techniques are used to find regions in the workspace representation where these trajectories are possible. A set of trajectories results. In the second stage mobile manipulator placements are computed and the corresponding trajectories are checked for collisions. Compared to a brute force search through the workspace, the success rate of finding a mobile manipulator placement can be increased from 2% to 70%.
An intra-task dvfs technique based on statistical analysis of hardware events (2007)

The importance and demand for various types of optimization techniques for program execution is growing rapidly. In particular, dynamic optimization techniques are regarded as important. Although conventional techniques usually generated an execution model for dynamic optimization by qualitatively analyzing the behaviors of computer systems in a knowledge-based manner, the proposed technique generates models by statistically analyzing the behaviors from quantitative data of hardware events. In the present paper, a novel dynamic voltage and frequency scaling (DVFS) method based on statistical analysis is proposed. The proposed technique is a hybrid technique in which static information, such as the breakpoint of program phases and, dynamic information, such as the number of cache misses given by the performance counter, are used together. Relationships between the performance and values of performance counters are learned statistically in advance. The compiler then inserts a run-time code for predicting the performance and setting the appropriate frequency/voltage depending on the predicted performance. The proposed technique can greatly reduce the energy consumption while satisfying soft timing constraints.
Dynamic Wetting of Hydrophobic Polymers by Aqueous Surfactant and Superspreader Solutions (2013)

In this paper, we comparatively investigated the wetting performance of aqueous surfactant solutions in a wide range of concentrations, including conventional ionic surfactants (CTAB, SDS) and two nonionic polyether-modified trisiloxane surfactants (TSS6/3, TSS10/2), over hydrophobic polypropylene substrates. In all cases, scaling analysis of the experimental data of spreading drops showed that the early spreading stage was dominated by inertia and that the duration of this stage was not influenced by the addition of surfactant. For conventional surfactant solutions, we only observed the inertia-dominated spreading stage before the drops stopped wetting with a finite stable contact angle. For both trisiloxane surfactants, after the inertial stage we observed a second viscosity-dominated spreading stage. In this stage, TSS10/2 showed an enhanced wetting capability independent of its concentration, while TSS6/3 started to show a concentration-dependent spreading behavior that was fully developed in a third superspreading stage. Our findings suggest that the superspreading property of TSS6/3 began to take effect after a characteristic time, before which the superspreading TSS6/3 and the nonsuperspreading TSS10/2 behaved similarly. Power law fits to the superspreading regime are in agreement with an interpretation of Marangoni flows resulting from surface tension gradients.
Conformational control in the regioselective synthesis of N-2-substituted-1,2,3-triazoles (2008)

An effective strategy for the synthesis of N-2-substituted-1,2,3-triazoles with excellent yields and regioselectivity has been developed.
One-way flow of a rarefied gas induced in a channel with a periodic temperature distribution (1996)

A rarefied gas in a channel of two parallel plane walls with a spatially periodic steady temperature distribution, on which a series of ditches is dug periodically, is considered, and the behavior of a flow induced by the temperature variation on the walls is investigated numerically for various Knudsen numbers and ditch sizes by the standard direct simulation Monte Carlo method (Bird’s method). It is found that a steady one-way flow is induced through the channel without any pressure gradient being applied externally. The pumping effect owing to the one-way flow is discussed.
Toward the Next Generation of Negative Symptom Assessments: The Collaboration to Advance Negative Symptom Assessment in Schizophrenia (2010)

Negative symptoms in schizophrenia are related to poor functional outcome, persistent over time, a source of burden for caregivers, and only minimally responsive to currently available medications. A major challenge to developing efficacious interventions concerns the valid and reliable assessment of negative symptoms. In a recent consensus statement on negative symptoms, a central recommendation was the need to develop new assessment approaches that address the limitations of existing instruments. In the current report, we summarize the background and rationale for the Collaboration to Advance Negative Symptom Assessment in Schizophrenia (CANSAS). The CANSAS project is an National Institute of Mental Health-funded multisite study that is constructing a next-generation negative symptom scale, the Clinical Assessment Interview for Negative Symptoms (CAINS). The CAINS is being developed within a data-driven iterative process that seeks to ensure the measure's reliability, validity, and utility for both basic psychopathology and treatment development research.
A guide to metaphorical design (1994)

article Free Access Share on A guide to metaphorical design Author: Kim Halskov Madsen A˚rhus Univ., A˚rhus, Denmark A˚rhus Univ., A˚rhus, DenmarkView Profile Authors Info & Claims Communications of the ACMVolume 37Issue 12Dec. 1994pp 57–62https://doi.org/10.1145/198366.198381Published:01 December 1994Publication History 99citation3,022DownloadsMetricsTotal Citations99Total Downloads3,022Last 12 Months65Last 6 weeks28 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Geldanamycin abrogates ErbB2 association with proteasome-resistant beta-catenin in melanoma cells, increases beta-catenin-E-cadherin association, and decreases beta-catenin-sensitive transcription. (2001)

Beta-catenin undergoes both serine and tyrosine phosphorylation. Serine phosphorylation in the amino terminus targets beta-catenin for proteasome degradation, whereas tyrosine phosphorylation in the COOH terminus influences interaction with E-cadherin. We examined the tyrosine phosphorylation status of beta-catenin in melanoma cells expressing proteasome-resistant beta-catenin, as well as the effects that perturbation of beta-catenin tyrosine phosphorylation had on its association with E-cadherin and on its transcriptional activity. Beta-catenin is tyrosine phosphorylated in three melanoma cell lines and associates with both the ErbB2 receptor tyrosine kinase and the LAR receptor tyrosine phosphatase. Geldanamycin, a drug which destabilizes ErbB2, caused rapid cellular depletion of the kinase and loss of its association with beta-catenin without perturbing either LAR or beta-catenin levels or LAR/beta-catenin association. Geldanamycin also stimulated tyrosine dephosphorylation of beta-catenin and increased beta-catenin/E-cadherin association, resulting in substantially decreased cell motility. Geldanamycin also decreased the nuclear beta-catenin level and inhibited beta-catenin-driven transcription, as assessed using two different beta-catenin-sensitive reporters and the endogenous cyclin D1 gene. These findings were confirmed by transient transfection of two beta-catenin point mutants, Tyr-654Phe and Tyr-654Glu, which, respectively, mimic the dephosphorylated and phosphorylated states of Tyr-654, a tyrosine residue contained within the beta-catenin-ErbB2-binding domain. These data demonstrate that the functional activity of proteasome-resistant beta-catenin is regulated further by geldanamycin-sensitive tyrosine phosphorylation in melanoma cells.
B***-tree: a family of efficient data packaging multiway trees (2002)

Presents the B***-tree, a data organization method which improves the storage utilization of the conventional B*-tree by 20%-50%. The B***-tree uses a special node data structure that eliminates some of the I/O overhead incurred during building the index. Moreover, an adaptation of the B***-tree in distributed memory multiprocessors is discussed. This structure guarantees 100% storage utilization, and incurs a tolerable message passing overhead, solely dependent on the branching factor of the tree.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Unraveling the Equine Lymphocyte Proteome: Differential Septin 7 Expression Associates with Immune Cells in Equine Recurrent Uveitis (2014)

Equine recurrent uveitis is a spontaneous, lymphocyte-driven autoimmune disease. It affects horses worldwide and presents with painful remitting-relapsing inflammatory attacks of inner eye structures eventually leading to blindness. Since lymphocytes are the key players in equine recurrent uveitis, we were interested in potential changes of their protein repertoire which may be involved in disease pathogenesis. To create a reference for differential proteome analysis, we first unraveled the equine lymphocyte proteome by two-dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis and subsequently identified 352 protein spots. Next, we compared lymphocytes from ERU cases and healthy horses with a two-dimensional fluorescence difference in gel electrophoresis approach. With this technique, we identified seven differentially expressed proteins between conditions. One of the significantly lower expressed candidates, septin 7, plays a role in regulation of cell shape, motility and migration. Further analyses revealed T cells as the main cell type with decreased septin 7 abundance in equine recurrent uveitis. These findings point to a possible pathogenetic role of septin 7 in this sight-threatening disease.
Remote Management of Non-TR-069 UPnP End-User Devices in a Private Network (2009)

End-to-end broadband service delivery requires remote management of devices in the home network, beyond the home gateway (HG). The service provider can only put limited requirements to these of-the-shelf devices, and therefore has to make intelligent use of their given control and management protocols. We developed a demonstrator for the remote management of Universal Plug and Play (UPnP) devices in the home with a simple TR-069/UPnP proxy on the HG. It shows how UPnP devices can be discovered, configured, controlled and monitored with a legacy TR-069 auto-configuration server.
Gasochromic WO3 Nanostructures for the Detection of Hydrogen Gas: An Overview (2019)

Hydrogen is one of the most important gases that can potentially replace fossil fuels in the future. Nevertheless, it is highly explosive, and its leakage should be detected by reliable gas sensors for safe operation during storage and usage. Most hydrogen gas sensors operate at high temperatures, which introduces the risk of hydrogen explosion. Gasochromic WO3 sensors work based on changes in their optical properties and color variation when exposed to hydrogen gas. They can work at low or room temperatures and, therefore, are good candidates for the detection of hydrogen leakage with low risk of explosion. Once their morphology and chemical composition are carefully designed, they can be used for the realization of sensitive, selective, low-cost, and flexible hydrogen sensors. In this review, for the first time, we discuss different aspects of gasochromic WO3 gas sensor-based hydrogen detection. Pristine, heterojunction, and noble metal-decorated WO3 nanostructures are discussed for the detection of hydrogen gas in terms of changes in their optical properties or visible color. This review is expected to provide a good background for research work in the field of gas sensors.
Geochemical Factors Controlling the Mobilization of Inorganic Constituents from Fossil Fuel Combustion Residues: II. Review of the Minor Elements (1990)

Abstract Past studies of the environmental aspects of fossil fuel waste disposal have focused on determining elemental concentrations, elemental distributions, and empirical rates of elemental extraction. The concentration data for the minor elements (i.e., As, B, Ba, Cd, Cr, Cu, Pb, Mn, Hg, Mo, Ni, Se, Sr, V, and Zn) are extremely variable and are dependent on fuel composition and combustion processes. Studies of elemental extraction rates have provided empirical information on short‐term leaching behavior that is relevant only to a specific waste sample. Extraction studies serve to characterize the initial states of wastes prior to disposal but generally have not provided information on the dominant weathering reactions that will control the long‐term concentrations of minor elements in the disposal environment. We propose that a more useful approach for understanding leachate chemistry involves the consideration of the thermodynamics of specific dissolution/precipitation, adsorption/desorption, and redox speciation reactions that occur during weathering in addition to empirical data. Because fossil fuel wastes are composed of high‐temperature solids that formed under conditions of combustion, this approach can be used to describe the reaction paths governing the alteration of the high‐temperature solids to assemblages of secondary solids and aqueous species that are stable in weathering environments. The depiction of leaching behavior through solubility and speciation relationships rather than through empirical interpretations of extraction rates allows one to establish bounds for the aqueous concentrations of various elements, given information on the chemistry of waste solids and on physical and chemical conditions. The determination of thermodynamic data and application of those data to understanding the leachate chemistry of the minor elements in the disposal environment remains an area where much research is needed.
ChemInform Abstract: Stability of the Metal Configuration in Chiral‐at‐Metal Half‐Sandwich Compounds (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Automatic Calculating Machines (1950)

When we write a number in the ordinary way, such as 673, the symbols such as 6, 7, 3 in this example stand for what we call the digits of the number, and a piece of mechanical or electrical equipment which operates with and records the discrete digits of each number is often called a digital calculating machine . In the past twelve years there has been a remarkable development of such machines with two important features. First, they can carry out lengthy and intricate calculations quite automatically once they have been supplied with a specification, in suitable form, of the calculation to be carried out, and secondly, they are very versatile, so that the same machine can be used for many quite different kinds of calculation, for example for evaluating values of a function from its power-series expansion, for solving large systems of linear simultaneous algebraic equations, for finding the characteristic values of matrices, for the step-by-step integration of ordinary differential equations. To express these two features, such machines are sometimes called general-purpose, automatic, digital calculating machines, and my purpose is to give an account of some aspects of such machines, both of the machines themselves and of the way in which they are used. I can only touch on some aspects, since there is not nearly enough time in a single lecture to deal with the subject fully.