gebhart/patrepeval huggingface dataset:
Aspects of Cache Memory and Instruction Buffer Performance (1987)

Techniques are developed in this dissertation to efficiently evaluate direct-mapped and set-associative caches. These techniques are used to study associativity in CPU caches and examine instruction caches for single-chip RISC microprocessors. This research is motivated in general by the importance of cache memories to computer performance, and more specifically by work done to design the caches in SPUR, a multiprocessor workstation designed at U.C. Berkeley. The studies focus not only on abstract measures of performance such as miss ratios, but also include, when appropriate, detailed implementation factors, such as access times and gate delays.
The simulation algorithms developed compute miss ratios for numerous alternative caches with one pass through an address trace, provided all caches have the same block size, and use demand fetching and LRU replacement. One algorithm (forest simulation) simulates direct-mapped caches by relying on inclusion, a property that all larger caches contain a superset of the data in smaller caches. The other algorithm (all associativity simulation) simulates a broader class of direct-mapped and set-associative caches than could previously be studied with a one-pass algorithm, although somewhat less efficiently than forest simulation, since inclusion does not hold.
The analysis of set-associative caches yields two major results. First, constant factors are obtained which relate to the miss ratios for set-associative caches to miss ratios for other set-associative caches. Then those results are combined with sample cache implementations to show that above certain cache sizes, direct-mapped caches have lower effective access times than set-associative caches, despite having higher miss ratios.
Finally, instruction buffers and target instruction buffers are examined as organizations for instruction memory on single-chip microprocessors. The analysis focuses closely on implementation considerations, including the interaction between instruction fetches, instruction prefetches and data references, and uses the SPUR RISC design as the case study. Results show the effects of varying numerous design parameters, suggest some superior designs, and demonstrate that instruction buffers will be preferred to target instruction buffers in future RISC microprocessors implemented on single CMOS chips.
Characterization of the capsular antigen of Streptococcus pneumoniae serotype 35B (1995)

The specific capsular antigen of Streptococcuspneumoniae serotype 35B was shown by a combination of 2D NMR methods and mass spectrometric and classical carbohydrate chemical techniques to be a high molecular weight polymer containing D-galactose, D-glucose, 2-acetamido-2-deoxy-D-galactose, and ribitol (2:1:1:1). The pentasaccharide repeating unit is polymerized through phosphate diester linkages to give the structure,[Formula: see text]Seventy percent of the β-D-Gal f residues glycosidically linked to the ribitol units carry an O-acetyl substituent. Keywords: Streptococcuspneumoniae, capsular antigen, polysaccharide structure.
Computation of recurrent minimal genomic alterations from array-CGH data (2006)

Supplementary data are available at Bioinformatics online.
New Waveforms for Selective-RoI-Signaling High-Rate Optical Camera Communication System (2018)

In this paper, we briefly discuss the potential of applying hybrid waveform into Optical Camera Communication, which can simultaneously transmit both low-rate and high-rate data streams for a challenging communication channel condition such as vehicular environment. The proper selection of suitable modulation schemes for these two simultaneous data streams along with the discussion on the impact of integrating data streams are overviewed.
Intramolecular Regulation of Protein Tyrosine Phosphatase SH-PTP1: A New Function for Src Homology 2 Domains (1994)

The steady-state kinetic properties of SH-PTP1 (PTP1C, SHP, HCP), a Src homology 2 (SH2) domain-containing protein tyrosine phosphatase (PTPase), were assessed and compared with those of three truncation mutants, using p-nitrophenyl phosphate, phosphotyrosyl (pY) peptides, and reduced, carboxyamido-methylated, maleylated, and tyrosyl-phosphorylated lysozyme as substrates. At physiological pH (7.4), truncation of the two N-terminal SH2 domains [SH-PTP1(delta SH2)] or the last 35 amino acids of the C-terminus [SH-PTP1(delta C35)] activated the phosphatase activity by 30-fold and 20-34-fold relative to the wild-type enzyme, respectively. Truncation of the last 60 amino acids resulted in a mutant [SH-PTP1(delta C60)] with wild-type activity. SH-PTP1 and SH-PTP1(delta C60) displayed apparent saturation kinetics toward pNPP only at acidic pH (pH < or = 5.4); as pH increased above 5.5, their apparent KM values increased dramatically. In contrast, SH-PTP1(delta SH2) obeyed normal Michaelis-Menten kinetics at all pH values tested (pH 5.1-7.4) with a constant KM (10-14 mM). Furthermore, two synthetic pY peptides corresponding to known and potential phosphorylation sites on the erythropoietin (EPOR pY429) and interleukin-3 (IL-3R pY628) receptors bound specifically to the N-terminal SH2 domain of SH-PTP1 (KD = 1.8-10 microM) and activated the catalytic activity of SH-PTP1 and SH-PTP1(delta C60) but not SH-PTP1(delta SH2), in a concentration-dependent manner. Maximal activation (25-30-fold) of SH-PTP1 was achieved at 70 microM EPOR pY429, and the maximally activated enzyme approached the activity of SH-PTP1(delta SH2). Addition of EPOR pY429 peptide, which corresponds to the recently identified in vivo binding site for SH-PTP1, at 40 microM also completely restored the saturation kinetic behavior of SH-PTP1 (at pH 7.4) toward pNPP, with catalytic parameters (KM = 12.8 mM, kcat = 3.2 s-1) similar to those of SH-PTP1(delta SH2). These data suggest that the SH2 domains of SH-PTP1 serve to autoinhibit the phosphatase activity of the PTPase domain. A model is proposed in which the SH2 domains interact with the PTPase domain in a pY-independent fashion and drive the PTPase domain into an inactive conformation.
Evaluation of Fungicide Seed Treatments for<i>Shrunken-2</i>('Supersweet') Sweet Corn (1993)

Strunken-2 («supersweet») sweet corn hybrids suffer serious stand losses due to seed rot, damping-off, and seedling blight caused by various seedborne and soilborne pathogens. To identify an optimal fungicide seed treatment to improve skrunken-2 sweet corn seedling stand in the field, we evaluated 30 treatments in 1989 and 11 in 1990 through a network of cooperators at 32 and 19 locations during 1989 and 1990, respectively. Treatment with a mixture of captan, thiram, metalaxyl, and benomyl (CTMB) was usually the best. In 1989 final stand with this mixture ranged from 13 to 86% (median 72%), compared to 1-72% (median 54%) for the untreated control. In 1990 treatment with CTMB produced stands of 8-91% (median 65%), compared to 0-89% (median 36%) for the control (.)
A Kinome RNAi Screen Identified AMPK as Promoting Poxvirus Entry through the Control of Actin Dynamics (2010)

Poxviruses include medically important human pathogens, yet little is known about the specific cellular factors essential for their replication. To identify genes essential for poxvirus infection, we used high-throughput RNA interference to screen the Drosophila kinome for factors required for vaccinia infection. We identified seven genes including the three subunits of AMPK as promoting vaccinia infection. AMPK not only facilitated infection in insect cells, but also in mammalian cells. Moreover, we found that AMPK is required for macropinocytosis, a major endocytic entry pathway for vaccinia. Furthermore, we show that AMPK contributes to other virus-independent actin-dependent processes including lamellipodia formation and wound healing, independent of the known AMPK activators LKB1 and CaMKK. Therefore, AMPK plays a highly conserved role in poxvirus infection and actin dynamics independent of its role as an energy regulator.
Zinc content of the<i>Bacillus anthracis</i>lethal factor (1994)

We present evidence that the anthrax toxin lethal factor binds multiple zinc atoms. Results from atomic adsorption spectroscopy indicate that lethal factor contains approximately three zinc atoms per toxin molecule. Lethal factor treated with EDTA and o-phenanthroline contained a similar number of zinc atoms, indicating that all three zinc atoms are tightly bound to the protein. Lethal factor contains the highly conserved zinc-binding consensus sequence, HExxH, that is present in all known zinc metalloproteases. In addition, lethal factor contains an inverted form of this motif, HxxDH, which may also be involved in zinc binding. Using a large array of protease model substrates, however, we were unable to detect an endogenous protease activity for lethal factor.
Stability Test for Additive-Treated Motor Oils (1949)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStability Test for Additive-Treated Motor OilsS. A. McKee and A. R. FritzCite this: Anal. Chem. 1949, 21, 5, 568–572Publication Date (Print):May 16, 1949Publication History Published online1 May 2002Published inissue 16 May 1949https://doi.org/10.1021/ac60029a010Request reuse permissionsArticle Views35Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (4 MB) Get e-Alertsclose Get e-Alerts
Electronic fluorescent ballast using a power factor correction technique for loads greater than 300 watts (2002)

The authors describe various power factor schemes used to correct the power factor in electronic ballast or other types of power supplies. This system provides an acceptable sine wave voltage and current to the laps. When the input DC voltage to the power inverter is varied the arc current is also varied, and thus a dimming system is possible. The power inverter used for the fluorescent lamp load is a current-fed sine wave inverter while the unique power factor correction and dimming is accomplished with a boost approach. Keeping the invertor the same, several historical passive techniques were designed, built, and tested. The results are given for a matrix of low, normal, and high line voltages of a 4 lamp load greater than 300 W.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Simulating network traffic flows with a massively parallel computing architecture (1993)

This paper presents a traffic network simulation model
Neglected Infections of Poverty in the United States of America (2008)

In the United States, there is a largely hidden burden of diseases caused by a group of chronic and debilitating parasitic, bacterial, and congenital infections known as the neglected infections of poverty. Like their neglected tropical disease counterparts in developing countries, the neglected infections of poverty in the US disproportionately affect impoverished and under-represented minority populations. The major neglected infections include the helminth infections, toxocariasis, strongyloidiasis, ascariasis, and cysticercosis; the intestinal protozoan infection trichomoniasis; some zoonotic bacterial infections, including leptospirosis; the vector-borne infections Chagas disease, leishmaniasis, trench fever, and dengue fever; and the congenital infections cytomegalovirus (CMV), toxoplasmosis, and syphilis. These diseases occur predominantly in people of color living in the Mississippi Delta and elsewhere in the American South, in disadvantaged urban areas, and in the US-Mexico borderlands, as well as in certain immigrant populations and disadvantaged white populations living in Appalachia. Preliminary disease burden estimates of the neglected infections of poverty indicate that tens of thousands, or in some cases, hundreds of thousands of poor Americans harbor these chronic infections, which represent some of the greatest health disparities in the United States. Specific policy recommendations include active surveillance (including newborn screening) to ascertain accurate population-based estimates of disease burden; epidemiological studies to determine the extent of autochthonous transmission of Chagas disease and other infections; mass or targeted treatments; vector control; and research and development for new control tools including improved diagnostics and accelerated development of a vaccine to prevent congenital CMV infection and congenital toxoplasmosis.
Leveraging Information in Parking Assistance Systems (2013)

This paper systematically explores the efficiency of uncoordinated parking space allocation in urban environments with two types of parking facilities. Drivers decide whether to go for inexpensive but limited on-street parking spots or for expensive yet overdimensioned parking lots, incurring an additional cruising cost when they decide for on-street parking spots but fail to actually acquire one. Their decisions are made under perfect knowledge of the total parking supply and costs and different levels of information about the parking demand, i.e., complete/probabilistic information and uncertainty. We take a game-theoretic approach and analyze the parking-space allocation process in each case as resource selection game instances. We derive their equilibria, compute the related price-of-anarchy (PoA) values, and study the impact of pricing on them. It is shown that, under typical pricing policies on the two types of parking facilities, drivers tend to overcompete for the on-street parking space, giving rise to redundant cruising cost. However, this inefficiency can be alleviated through systematic manipulation of the information that is announced to the drivers. In particular, counterintuitive less-is-more effects emerge regarding the way that information availability modulates the resulting efficiency of the process, which underpin general competitive service provision settings.
What the Words Mean: Teaching Young Actors the Value of Language. (1999)

An intra-abdominal laparoscopic cleaning device can effectively clean the laparoscopic lens and lead to less workflow interruption. Although not documented in this study, it may also lead to shorter operative times.
Phonaesthetically speaking (1995)

An examination of why people regard some words as inherently more beautiful than others
Space domain multistage interference canceller for SDMA (2002)

It is difficult for the adaptive array to reduce interference signals efficiently from the received signals when the interference signals and desired signal are closely located. This is a serious problem for a spatial division multiple access (SDMA) system using the multibeam adaptive array as a multiuser detector. We propose a space domain multistage interference canceller (SD-MIC) for the SDMA. Its performance is evaluated in frame error rate (FER) by computer simulations, considering uplink environment in the Japanese personal handy-phone system (PHS). The results show the remarkable improvement in high spatial correlation situations.
Dentigerous cyst involving mandibular third molar: Conservative treatment with radiologic follow-up and review of literature (2013)

Dentigerous cyst is the second most common odontogenic cyst and constitutes around 20-24% of all the odontogenic cysts involving the jaws. Usually, these cysts remain asymptomatic and rarely cause enlargement and displacement of associated tooth. In this paper, we present a case of a displaced mandibular third molar, which was associated with a large dentigerous cyst. A conservative treatment modality was adopted with a 2 year radiographic follow-up of the patient. A brief review of previously r
A Latent Semantic Model with Convolutional-Pooling Structure for Information Retrieval (2014)

In this paper, we propose a new latent semantic model that incorporates a convolutional-pooling structure over word sequences to learn low-dimensional, semantic vector representations for search queries and Web documents. In order to capture the rich contextual structures in a query or a document, we start with each word within a temporal context window in a word sequence to directly capture contextual features at the word n-gram level. Next, the salient word n-gram features in the word sequence are discovered by the model and are then aggregated to form a sentence-level feature vector. Finally, a non-linear transformation is applied to extract high-level semantic information to generate a continuous vector representation for the full text string. The proposed convolutional latent semantic model (CLSM) is trained on clickthrough data and is evaluated on a Web document ranking task using a large-scale, real-world data set. Results show that the proposed model effectively captures salient semantic information in queries and documents for the task while significantly outperforming previous state-of-the-art semantic models.
Correlation between Serum Leptin Levels, Body Mass Index and Obesity in Omanis (2006)

We concluded that serum leptin levels are higher in the Omani obese group and correlate positively with body fatness and obesity.
Measurement of exciton diffusion lengths in optically thin organic films (2011)

Spectrally resolved photoluminescence quenching (SR-PLQ) is a convenient and accurate method for measuring the exciton diffusion length of organic materials; however, the requirement of optically thick films demanded by this technique poses practical limitations to its implementation. Through simulations of the optical field and exciton dynamics, we extend SR-PLQ to the case of optically thin organic films; i.e., films whose thickness is comparable to or less than that of the optical absorption length across the entire optical absorption spectrum. This allows for the characterization of films whose thickness is comparable to that used in practical organic optoelectronic devices. Using this method, we measure the diffusion lengths of several squaraine donors, the acceptor 3,4,9,10 perylenetetracarboxylic dianhydride, and the relationship between the donor, boron subphthalocyanine thickness and diffusion length.
Novel architecture for emulation of sensor protocols for complaince checking using Generic Timer Module (2015)

To qualify a System-on-Chip (SoC) for automotive standards, all the interfaces have to be thoroughly checked against the specifications/standards. Sensor protocols which are new to the automotive world don't have the complete range of sensors available as of today for checking the complete features. These sensors operate over a limited range, are not capable of generating all possible frame formats, and lack error injection capability. In order to evaluate complete features of this Sensor IPs, sensor protocol has to be emulated. Existing trends consist of emulating the IP on FPGA or by using a waveform generator. Here, the sensor data is generated as per the sensor protocol standard using the Generic Timer Module (GTM) available on the SoC. In this work, we use Infineon's SoC to generate frames using GTM and validate the complete features of sensor interfaces like Single Edge Nibble Transmission (SENT) and Peripheral Sensor Interface (PSI5) present on the same SoC.
Exercise Standards for Testing and Training (2001)

T he purpose of this report is to provide revised standards and guidelines for the exercise testing and training of individuals who are free from clinical manifestations of cardiovascular disease and those with known cardiovascular disease. These guidelines are intended for physicians, nurses, exercise physiologists, specialists, technologists, and other healthcare professionals involved in exercise testing and training of these populations. This report is in accord with the "Statement on Exercise" published by the American Heart Association (AHA). An update of background, scientific rationale, and selected references is provided, and current issues of practical importance in the clinical use of these standards are considered. These guidelines are in accord with the American College of Cardiology (ACC)/AHA Guidelines for Exercise Testing. Specifically, all members of the writing group are required to complete and submit a Disclosure Questionnaire showing all such relationships that might be perceived as real or potential conflicts of interest.
Fast reproducible identification and large-scale databasing of individual functional cognitive networks (2007)

This collection of individual fMRI data will help to describe the cerebral inter-subject variability of the correlates of some language, calculation and sensorimotor tasks. In association with demographic, anatomical, behavioral and genetic data, this protocol will serve as the cornerstone to establish a hybrid database of hundreds of subjects suitable to study the range and causes of variation in the cerebral bases of numerous mental processes.
In vitro processing of dengue virus type 2 nonstructural proteins NS2A, NS2B, and NS3 (1990)

We have tested the hypothesis that the flavivirus nonstructural protein NS3 is a viral proteinase that generates the termini of several nonstructural proteins by using an efficient in vitro expression system and monospecific antisera directed against the nonstructural proteins NS2B and NS3. A series of cDNA constructs was transcribed by using T7 RNA polymerase, and the RNA was translated in reticulocyte lysates. The resulting protein patterns indicated that proteolytic processing occurred in vitro to generate NS2B and NS3. The amino termini of NS2B and NS3 produced in vitro were found to be the same as the termini of NS2B and NS3 isolated from infected cells. Deletion analysis of cDNA constructs localized the protease domain within NS3 to the first 184 amino acids but did not eliminate the possibility that sequences within NS2B were also required for proper cleavage. Kinetic analysis of processing events in vitro and experiments to examine the sensitivity of processing to dilution suggested that an intramolecular cleavage between NS2A and NS2B preceded an intramolecular cleavage between NS2B and NS3. The data from these expression experiments confirm that NS3 is the viral proteinase responsible for cleavage events generating the amino termini of NS2B and NS3 and presumably for cleavages generating the termini of NS4A and NS5 as well.