gebhart/patrepeval huggingface dataset:
First experiments with the ATL model transformation language: Transforming XSLT into XQuery (2003)

ATL (Atlas Transformation Language) has been defined to perform general transformations within the MDA framework (Model Driven Architecture) recently proposed by the OMG. We are currently learning from the first applications developed with this language. The example used here is a transformation from XSLT to XQuery. Since these are two standard notations that don’t pertain to the MDA space, we first need to provide some justification about this work. The global organization of technological spaces presented at the beginning of the paper is intended to answer this first question. Furthermore we propose the original characterization of a technological space as a framework based on a given unique meta-model. After having briefly presented the ATL framework, we describe the XSLT2XQuery transformation. We may then draw several conclusions from this experiment, suggesting possible improvements to general model transformation frameworks. ATL is still evolving since it is supposed to match the forthcoming QVT/RFP recommendation when it is ready. As a consequence, the concrete expression of the transformation presented in this paper may change, but the general ideas should remain stable.
<i>Bifidobacterium</i><i>animalis</i> subsp. <i>lactis</i> BB-12 in reducing the risk of infections in infancy (2010)

The impact of controlled administration of Bifidobacterium animalis subsp. lactis BB-12 (BB-12) on the risk of acute infectious diseases was studied in healthy newborn infants. In this double-blind, placebo-controlled study, 109 newborn 1-month-old infants were assigned randomly to a probiotic group receiving a BB-12-containing tablet (n 55) or to a control group receiving a control tablet (n 54). Test tablets were administered to the infants twice a day (daily dose of BB-12 10 billion colony-forming units) from the age of 1-2 months to 8 months with a novel slow-release pacifier or a spoon. Breastfeeding habits, pacifier use, dietary habits, medications and all signs and symptoms of acute infections were registered. At the age of 8 months, faecal samples were collected for BB-12 determination (quantitative PCR method). The baseline characteristics of the two groups were similar, as was the duration of exclusive breastfeeding. BB-12 was recovered (detection limit log 5) in the faeces of 62% of the infants receiving the BB-12 tablet. The daily duration of pacifier sucking was not associated with the occurrence of acute otitis media. No significant differences between the groups were observed in reported gastrointestinal symptoms, otitis media or use of antibiotics. However, the infants receiving BB-12 were reported to have experienced fewer respiratory infections (65 v. 94%; risk ratio 0·69; 95% CI 0·53, 0·89; P = 0·014) than the control infants. Controlled administration of BB-12 in early childhood may reduce respiratory infections.
The relationship of β‐glucuronidase activity in crevicular fluid to clinical parameters of periodontal disease (1994)

Previous reports have suggested that persistently elevated levels of the acidic glycohydrolase beta-glucuronidase (beta G) in gingival crevicular fluid (GCF) can identify patients with chronic adult periodontitis who are at risk for future probing attachment loss (PAL). To comprehensively study beta G activity in GCF, a multicenter trial examining the relationship of the enzyme in GCF to traditional clinical parameters of periodontal disease and PAL was conducted. In this report, the baseline data was used to evaluate the relationship of beta G activity in GCF to traditional parameters of periodontal disease. The study group included 130 patients who had been treated for periodontal disease and were on a regular recall schedule, and 10 patients with chronic adult periodontitis who had never received treatment. Upon entering the longitudinal trial, the patients were examined, and a standardized 30-s GCF sample was collected from the mesiobuccal crevice of all study teeth. As a control, GCF samples and clinical data were collected from 62 patients with a healthy periodontium or mild inflammatory gingivitis without loss of probing attachment. At baseline, beta G activity for the periodontitis patients ranged from 0 to 1704 Units (U), with a median of 32 U. beta G could not be detected in 0.2% of samples (activity < or = 2.0 U). The 90% cumulative relative frequency was 139 U. For the healthy/gingivitis subjects beta G activity ranged from 0 to 504 U, with a median of 22 U. Enzyme was not detectable in 0.4% of samples. Only 0.9% of samples contained greater than 139 U. beta G activity in GCF was not related to gender or age. For the periodontitis patients, elevated enzyme activity (> or = 140 U) was most often associated with molar teeth, followed by maxillary bicuspids. Maxillary central incisors, and mandibular central and lateral incisors displayed the lowest frequency of elevated enzyme activity. The relationship of beta G activity to the traditional parameters of probing depth and bleeding on probing was assessed. For shallow sites (1.0-1.5 mm, 2.0-2.5 mm probing depth), the large majority of GCF samples contained low enzyme activity (90% of samples < 50 U). Descriptive indicators demonstrated a trend of increased beta G activity with increased probing depth. The median beta G activity shifted from 15 U for the shallowest sites (1.0-1.5 mm) to 127 U for the deepest sites (5-8 mm). However, this was due to a broadening of the distribution rather than representing a shift in the distribution profile.(ABSTRACT TRUNCATED AT 400 WORDS)
Elementary Gravity and Magnetics for Geologists and Seismologists (1971)

The purpose of this work is a general review of the gravity and magnetic nlethodsods of geophysicael xplorationa s applied in the search for petroleum. This material is not designed for the gravity and magnetic specialistb ut rather lo)r the geologistsa nd seismologistwsh o may not have a thorough appreciation of the applications of these metht)ds in the overall expl()ration picture. A subtitlc for this monograph might well be -l'hc Other Five Percerot. This is because the seismic method and its associated data processing account for sornc 95 percent of the total expenditures Ik)r petroleum exploration geophysicss o that whatever application is made of the gravity and magnetic noethods comes out of the other 5 percent. This does not mean that these methods make a proportionately small contribution to the overall exploration effort. Because of the relatively rapid rate of progress in the field, particularly by airborne magnetics. the total area covered by gravity and magnetic surveys may bc greater than that covered by the much greater seismic expendituresA. s a very rough rule-ofthumb, the relative cost per unit area of magneticg, ravity and seismicf ield work with data processings tand in the ratio of I to 10 to 100. It is the hope and purposeo f this monographth at a better appreciatioonf the valueo f the potential methods and understanding of their applicationsm ay be broughta bouts t) that they can be applied with proper perspective in the overall exploration picture. From the beginning of geophysical exploration in the petroleum industry in the 192()'s, three basic physical principles were used: i.e., the measurement of small variations in the magnetic field, the measurement of small variations in the gravitational field, and the propagation of elastic waves through the earth. These three and only these three physical principles are the basis for practically all of the geophysical work up to the present time. Many other methods have been conceived and tried in the field in a limited way, but none has persisted to the extent that field operations are carried out n a scale at all comparable with that of the three primary methods listed above. The seismic method, of course, usually is much more direct in its relation to the geologyt han the potentialm ethodsR. etlection zones or horizons frequently are directly correlative with geologic strata and give relativelya ccuratem easureosf their depth and form.
Development of an Enzyme-Linked Immunosorbent Assay for Serotyping <i>Ureaplasma urealyticum</i> Strains Using Monoclonal Antibodies (2001)

Ureaplasma urealyticum comprises 14 serotypes. The existing serotyping methods all use polyclonal antibodies. These methods are time-consuming and labor-intensive, and they cannot always be performed on primary isolates; in addition, the results are difficult to interpret. We developed a new enzyme-linked immunosorbent assay (ELISA) method using serotype-specific monoclonal antibodies (MAbs) to enable the serotyping of U. urealyticum isolates from primary broth cultures. Each of the 14 serotype reference strains was tested against 14 selected MAbs. Homologous reactions were very strong, while heterologous reactions were negligible. Three cross-reactions were observed: MAb 5 cross-reacted with serotype 2, MAb 14 cross-reacted with serotype 3, and MAb 8 cross-reacted with serotype 13. Despite the cross-reactions observed, all the serotype reference strains of U. urealyticum could be identified and differentiated using a combination of MAbs. Reproducibility was analyzed with a fractionated antigenic preparation and with several freshly prepared antigens of the same strain. No significant interrun variation was found with the fractionated antigen, but significant variations in optical density (OD) values were found when freshly prepared antigens were tested. However, the variation in OD values did not influence the overall interpretation of the ELISA: reactions with homologous MAbs were always prominent compared to those of the negative controls. This newly developed ELISA using MAbs seems promising for serotyping of U. urealyticum clinical isolates.
Retargeting Lentiviruses via SpyCatcher-SpyTag Chemistry for Gene Delivery into Specific Cell Types (2017)

We report a simple strategy for the creation of lentiviral vectors specific to any desired target cells. SpyTag is inserted into an engineered Sindbis virus envelope protein and displayed on the lentivirus surface to create Sindbis virus-SpyTag pseudoparticles (Sind-SpyTag-pp). The SpyTag serves as the covalent anchoring site for a target-cell-specific cell-binding protein (CBP) that is fused to a truncated SpyCatcher (SpyCatcherΔ). Target-cell-specific lentiviruses are created by mixing the Sind-SpyTag-pp and CBP-SpyCatcherΔ <i>in vitro</i> We first used a HER2-binding designed ankyrin repeat protein (DARPin.9.26) as the model CBP. The DARPin-conjugated lentivirus transduced HER2<sup>+</sup> SKOV3 cells with an infectious titer of 5.2 × 10<sup>6</sup> IU/ml, >500-fold higher than the unfunctionalized "naked" virions (<10<sup>4</sup> IU/ml). The ability of the DARPin-conjugated lentivirus to transduce HER2<sup>+</sup> cells correlated with the surface expression level of HER2. Furthermore, these lentiviruses preferentially transduced HER2<sup>+</sup> cells in cocultures containing HER2<sup>+</sup> and HER2<sup>-</sup> cells. To enable the use of commercially available monoclonal antibodies (MAbs) as the CBP, we developed a convenient click chemistry-based approach to conjugate MAb-derived Fab fragments to a variant SpyCatcherΔ protein containing a nonnatural amino acid, 4-azido-l-phenylalanine (AzF). Using the HER2-binding trastuzumab as a model cell-specific MAb, we created Fab-conjugated lentiviral vectors that transduced HER2<sup>+</sup> SKOV3 cells with an infectious titer of 2.8 × 10<sup>6</sup> IU/ml, on par with the result achieved using the DARPin-SpyCatcherΔ fusion protein. The ability to create cell-specific lentiviral vectors through chemical conjugation of a CBP should make this approach generalizable to any antibody, giving it broad utility for a wide range of research and clinical applications.<b>IMPORTANCE</b> Lentiviral vectors hold great potential in gene therapy. However, it remains a major hurdle to robustly engineer cell-specific lentiviral vectors. This article reports a simple and effective strategy to functionalize lentiviral vectors with cell-binding proteins, thus retargeting these viruses to cells expressing the binding partner of the CBP. The CBP is genetically or chemically linked to the SpyCatcher. The SpyTag is displayed on the virion surface as a fusion to an engineered Sindbis virus envelope protein and is used as the anchorage site for SpyCatcher-linked CBP. Using this strategy, we created lentiviral vectors highly infectious toward HER2<sup>+</sup> cancer cells. The ability to rapidly create cell-specific lentiviral vectors targeting a wide range of cell types should accelerate the development of custom lentiviral vectors for many research and clinical applications.
Mono- and Difunctional Analogs of Some Quinoline and Acridine Nitrogen Mustards<sup>1</sup> (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMono- and Difunctional Analogs of Some Quinoline and Acridine Nitrogen Mustards1RICHARD M. PECK, ROBERT K. PRESTON, and HUGH J. CREECHCite this: J. Org. Chem. 1961, 26, 9, 3409–3414Publication Date (Print):September 1, 1961Publication History Published online1 May 2002Published inissue 1 September 1961https://pubs.acs.org/doi/10.1021/jo01067a094https://doi.org/10.1021/jo01067a094research-articleACS PublicationsRequest reuse permissionsArticle Views214Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Large area, low capacitance Si(Li) detectors for low noise, high rate X-ray applications (2003)

Summary form only. Large-area, single-element Si(Li) detectors have been fabricated using a novel geometry which yields detectors with reduced capacitance and hence reduced noise at short amplifier shaping times. A typical 6-mm-thick device with an active area of 175 mm/sup 2/ has a capacitance of 0.5 pF for a conventional planar device with equivalent thickness and area. These low-capacitance detectors, in conjunction with low-capacitance FETs, will result in spectrometers capable of running at very high count rates while still maintaining excellent energy resolution. The spectral response of the low capacitance detectors to a wide range of X-ray energies at 77 K is comparable to that of typical state-of-the-art conventional Si(Li) devices. The spectral response to 2-60 keV X-rays was investigated.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Real-time expression cloning using appearance models (2007)

Active Appearance Models (AAMs) are generative parametric models commonly used to track, recognise and synthesise faces in images and video sequences. In this paper we describe a method for transferring dynamic facial gestures between subjects in real-time. The main advantages of our approach are that: 1) the mapping is computed automatically and does not require high-level semantic information describing facial expressions or visual speech gestures. 2) The mapping is simple and intuitive, allowing expressions to be transferred and rendered in real-time. 3) The mapped expression can be constrained to have the appearance of the target producing the expression, rather than the source expression imposed onto the target face. 4) Near-videorealistic talking faces for new subjects can be created without the cost of recording and processing a complete training corpus for each. Our system enables face-to-face interaction with an avatar driven by an AAM of an actual person in real-time and we show examples of arbitrary expressive speech frames cloned across different subjects.
Simple Analytical Design of Modified Smith Predictor with Improved Performance for Unstable First-Order Plus Time Delay (FOPTD) Processes (2007)

A simple method of designing the controllers for the modified Smith predictor scheme with improved closed-loop performances is proposed for open-loop unstable first-order plus time delay (FOPTD) processes. The proposed method consists of two controllers that are meant for different objectives, namely, the set-point tracking and simultaneous stabilization of the unstable process with time delay and the load disturbance rejection. The design steps of these two controllers are independent. The direct synthesis method is used to design the set-point tracking controller, and simple analytical tuning rules are provided for the load disturbance controller. Robustness studies on the stability and performance are provided, with respect to the uncertainties in the unstable process model parameters. The proposed scheme consists of only one tuning parameter. Good nominal and robust control performances are achieved with the proposed method. Significant improvement in the closed-loop performances are obtained, when compared to the recently reported methods.
Identification of Cytosolic Antigens from GW-39 Adenocarcinoma Cells by Crossed Immunoelectrophoresis and Immunofluorescence (1983)

Rabbits were immunized with a cytosolic fraction prepared from human adenocarcinoma cells of the colon (GW-39). The antibodies obtained were analyzed using crossed immunoelectrophoresis and were found to precipitate 23 distinct antigens in the cytosolic fraction from colon tumor cells. After preabsorption with human serum and plasma as well as acetone powders prepared from 2 normal human tissues and 4 normal hamster tissues, 1 major immunodominant cytosol antigen (CA-3) and two less intense immunoprecipitin peaks (CA-1 and CA-5) remained detectable by the crossed immunoelectrophoretic method. The preabsorptions with normal tissues were sufficiently complete to remove anti-carcinoembryonic antigen antibodies and showed that antigens CA-1, CA-3 and CA-5 are immunologically distinct from carcinoembryonic antigen. Indirect immunofluorescence localization studies with preabsorbed anti-cytosol antibodies and FITC-conjugated second antibody showed that these antigens were expressed in the cytoplasm and at the cell surface in several human colon tumor cell lines, their subclones and in primary colon tumor specimens.
Multiplex polymerase chain reaction for detection of genes for<i>Staphylococcus aureus</i>thermonuclease and methicillin resistance and correlation with oxacillin resistance (1993)

A multiplex polymerase chain reaction (mPCR) was used for simultaneous amplification of the staphylococcal nuc gene, encoding the thermostable nuclease (TNase), and the mecA gene, encoding the penicillin-binding protein 2a which is associated with staphylococcal methicillin resistance. A total of 219 staphylococcal strains were tested and the mPCR data were compared with coagulase production and in vitro oxacillin susceptibility. The agreement was 100% for coagulase production and nuc amplification, and 97.7%, 96.8 and 97.3% for mecA amplification and oxacillin resistance tested with MIC determination, disk diffusion and agar screen methods, respectively. Discrepant results were due to non-S. aureus isolates with borderline MICs of oxacillin (1-8 micrograms/ml). In a pilot test the mPCR simultaneously amplified both genes of staphylococci in blood cultures. This mPCR is a rapid and reliable method for single-step identification of cultures of MRSA and may prove to be useful for direct application on clinical specimens.
Applications of Microwave Thawing to the Recovery of Deep Frozen Cells and Organs:A Review<sup>*</sup> (1974)

Large microwave insults, at a frequency of 2450 MHz, have been applied to deep-frozen adult canine kidneys, fetal mouse hearts and tissue culture cells, causing controlled temperature changes at rates up to 300°C/min, from −196°C to 23 ± 12°C. This paper describes the two microwave systems which have been used for heating a number of different biological samples, ranging in volume from 2 to 10ml, and presents some of the results obtained, together with the method used.The electrical activity of fetal mouse hearts, recovered from −196°C by microwave heating, has survived in a high percentage of cases. The hearts were taken from 17 to 19 day old embryos, frozen in 5 ml samples of Minimum Essential Medium with 25 mm Hepes buffer, 10% dimethyl sulfoxide and 10% fetal calf serum. Subsequent subcutaneous implantation in the ear of syngeneic adult mice was used; in this way electrical activity has been studied for periods up to 35 days. Resumption of electrical activity is obtained by microwave and water bath thawing. Tissue culture cells will also withstand rapid thawing in a resonant microwave system operating at very high (near breakdown) field strengths. Uniform microwave thawing of adult frozen canine kidneys has been obtained at rates between 100 and 300°C/min from −79°C. It is now possible to control the heating to an end point of 23°C with a variation across the organ of < ± 12°C, providing prior perfusion of the organ was complete. Although subsequent functional success has not yet been achieved with frozen thawed canine kidneys, certain areas of viable tissue, with vascular integrity, have been observed.
Bidirectional WDM self-healing ring network for hub/remote nodes (2003)

We demonstrate a bidirectional wavelength-division-multiplexing self-healing ring network for hub/remote nodes with a single strand of fiber. In this network, self-healing can be achieved within 8 ms. The transmission capacity can be doubled in the operating state. We observed the improvement of power penalty due to the spectral filtering in the realized network with 2.5-Gb/s directly modulated signals.
Implementation of the CELL Broadband Engine in a 65nm SOI Technology Featuring Dual-Supply SRAM Arrays Supporting 6GHz at 1.3V (2007)

The 65nm CELL Broadband Enginetrade design features a dual power supply, which enhances SRAM stability and performance using an elevated array-specific power supply, while reducing the logic power consumption. Hardware measurements demonstrate low-voltage operation and reduced scatter of the minimum operating voltage. The chip operates at 6GHz at 1.3V and is fabricated in a 65nm CMOS SOI technology.
Model checking transactional memories (2008)

Model checking software transactional memories (STMs) is difficult because of the unbounded number, length, and delay of concurrent transactions and the unbounded size of the memory. We show that, under certain conditions, the verification problem can be reduced to a finite-state problem, and we illustrate the use of the method by proving the correctness of several STMs, including two-phase locking, DSTM, TL2, and optimistic concurrency control. The safety properties we consider include strict serializability and opacity; the liveness properties include obstruction freedom, livelock freedom, and wait freedom.