gebhart/patrepeval huggingface dataset:
Sex and the human female reproductive tract--what really happens during and after coitus. (1998)

The scientific study of the interaction of human genitals during coitus and after ejaculation with and without female orgasm has always been difficult and controversial with ethical, technical and social problems. The present brief review examines critically the results from these studies. Early observations utilised changes induced in sexually self-aroused subjects or by coitus with artificial (transparent) penes with few objective measurements. These culminated in the synthesis of the useful unitary descriptive, EPOR (excitation, plateau, orgasm, resolution)-model by Masters and Johnson (1966). Later investigations by other workers developed or employed instrumentation to record objectively the changes induced in the motility and pressures of genital muscles, in genital blood flow, in the ion and fluid movements creating the neurogenic transudate of vaginal lubrication, in its pH and pO2 and in the disposition of the ordered spurting ejaculate with subsequent sperm transport. More recently, studies have begun to use endoscopy and ultrasound imaging to picture what really happens especially during penile thrusting. While the newer techniques have often confirmed selected features of the original EPOR model they have also shown that the characterisation of the coital changes just by a unitary model is inappropriate. New observations suggest a plurality in the changes that can occur. Coital mechanisms are dynamic and our investigations and descriptions of them should match their dynamism. The knowledge gained will be more than helpful in the treatment of infertility, genital dysfunctions and disease transmission.
HTTP Alternative Services (2016)

This document specifies "Alternative Services" for HTTP, which allow an origin's resources to be authoritatively available at a separate network location, possibly accessed with a different protocol configuration.
Abstract B6: PEGPH20 depletion of pericellular hyaluronan sensitizes high hyaluronan-producing tumor cells in antibody-dependent cell-mediated cytotoxicity (2012)

Abstract Monoclonal antibodies (MAbs) have been developed successfully as part of the anticancer armamentarium. However, even in cases where the target of the antibody is stably and abundantly expressed, efficacy often falls below expectations. The tumor microenvironment (TME) has previously been shown to contribute to resistance to MAb therapy because matrix-associated high interstitial fluid pressure inhibits efficient drug penetration (1). Hyaluronan is an important component of the extracellular matrix (ECM) in about 25% of tumors, and 56% of breast cancers. This glycosaminoglycan is produced by malignant and stromal cells and acts to cross-link ECM proteins, contributing to the desmoplastic phenotype. Accumulation of HA has been associated with more aggressive malignancy (2).In this work, we show that &gt;50% of p185HER2-overexpressing breast tumors have a high accumulation of HA (HA+3). We hypothesized that tumor cells which overexpress HA create a protective “turtle shell” when it cross-links other ECM proteins (e.g., versican), and this pericellular structure protects the HER2-overexpressing tumor cell from attack by antibody-mediated cellular cytotoxicity (ADCC). SKBR3 (overexpressing p185HER2) and MDA-MB-231 (expressing EGFR) breast tumor cells were transfected with hyaluronan synthase 2 (HAS2), creating SKBR3/HAS2 (HA+3) and MDA-MB-231/HAS2 (HA+2), enabling these cells to form substantial pericellular matrices. NK-cell/trastuzumab/cetuximab-mediated ADCC is diminished in both of the HAS2-transfected cell types, suggesting that HA accumulation may contribute to tumor cell resistance to ADCC. Similarly, when these cells are treated in vitro with PEGPH20, a pegylated PH20 hyaluronidase (3), sensitivity to trastuzumab/cetuximab-mediated ADCC of the HAS2-overexpressing tumor cells is increased by up to 2-fold. These experiments show that the pericellular matrix coat (“turtle shell”) of high HA-producing tumor cells can inhibit the access of human immune cells to target cells, and that this effect can be reversed by depleting HA using PEGPH20. In vivo studies have shown that only PEGPH20, and not native PH20, has the bioavailability to induce antitumor activity in vivo. Models are currently in development to test whether PEGPH20 will enhance the activity of therapeutic MAbs in vivo.
Adsorption, Movement and Distribution of Carbofuran in different Soils (1996)

Adsorption and movement of carbofuran (a systemic non-ionic nematicide/insecticide) was studied with 3 different soils (silt loam, loam and sandy loam) of alluvial origin. The adsorption isotherms and Freundlich constants were determined by using the batch shake technique. The distribution coefficient KD values for the soils were determined by using the batch adsorption and soil column techniques, respectively. Carbofuran movement, in air dried and water saturated soil columns, by leaching the soii with distilled water was in rererse order of adsorption for all the soils studied. A heavy rainfall such as 915.54, 776.22 and 640.87 cm will be needed to leach carbofuran to 152 cm depth in silt loam. loam and sandy loam soils, respectively in field conditions.
Effect of calcium and cholecalciferol treatment for three years on hip fractures in elderly women (1994)

demand among the general practitioners for postmortem reports.Local pathologists and coroners do not routinely supply reports to the general practitioner, but general practitioners clearly want them to.Similar findings have been reported elsewhere.' Irrespective of who requests postmortem examin- ations, the benefits of the findings may be lost if reports are not readily available to the relevant doctors, whether they work in a hospital or in the community.We propose that a copy of every postmortem report should be sent to the family health services authority, which could forward it to the appropriate general practitioner.
Negotiation over offspring care?—a positive response to partner-provisioning rate in great tits (2005)

Game theoretical models of biparental care predict that a change in work rate by one parent should be met by incomplete compensation by its partner. However, in empirical studies on biparental birds, there has been some inconsistency in the direction and extent of the response, and the mechanism behind it has so far been unclear. Parents could be responding directly to partner work rate or indirectly via chick begging. In this study of great tits (Parus major), the work rate of one parent was increased experimentally by augmenting the begging of the chicks with playback of extra begging calls whenever the parent visited the nest. The playback had no effect on the chicks' begging behavior, so any change in the focal parent's behavior was a direct response to its partner's work rate over a short timescale. An experimental increase in care by either male or female parent led to an increase (to a lesser extent) in the work rate of its partner, which is counter to the decrease predicted by partial compensation models. This seemingly paradoxical result may reflect decisions made exclusively over a short timescale and is in keeping with new theoretical work, which takes into account the information content of partner work rates.
Effects of Different Atrial Pacing Modes on Atrial Electrophysiology (1997)

Biatrial pacing reduced both the atrial conduction delay and increase of electrogram width at the RPS caused by early S2 at HRA, and these effects could prevent induction of atrial fibrillation.
An optical-fiber multiterminal data system for aircraft (1979)

Abstract As a result of a study on the potential of optical-fiber multiterminal data systems for avionics, a design approach has been chosen that is expected to be a suitable basis for a wide range of applications. This is a time division multiplexing system, which has features of being highly immune to problems of optical loss and multipath effects in optical highways having redundant paths, and of avoiding the need for any master terminal. This system approach is tailored to characteristics of optical fibers, and should lead to good integrity and ruggedness. A breadboarded model of a terminal has been demonstrated, and the construction of functional models is currently under way.
Methanol Selective Oxidation to Formaldehyde over Iron‐Molybdate Catalysts (2005)

This review deals with the important industrial reaction of formaldehyde manufacture by methanol oxidation over iron molybdate catalysts. Detailed reference is made to the used catalyst, preparation techniques (coprecipitation, sol‐gel like, mechanical mixing, etc.) including unsupported and supported catalysts, promoters and characterization methods. The controversial active phase assignment (stoichiometric versus Mo rich iron molybdate) is discussed. The proposed reaction mechanisms and kinetic laws for the main and side reactions are examined. The catalyst deactivation processes are reviewed and the role of Mo excess on these processes is underlined. Finally conclusions and perspectives are presented.
Introduction (1993)

A successor to his own Rublyov, an icon painter in film, a commentator on our modern condition, Tarkovsky sought a state of harmony between the inward, spiritual life and the outward material world in which man lives. He perceived the potential of film for charting the modern space-time dimension we inhabit.KeywordsFemale RoleFilm MakerSoviet AuthorityAesthetic IdeaEarly FilmThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Photochemical preparation and rearrangement of some symmetrical methoxypyridyl phenyl glycols (pinacols) (1971)

Abstract Solutions of 6‐methoxy‐3‐pyridyl phenyl ketone and 3‐, 4‐, 5‐ and 6‐methoxy‐2‐pyridyl phenyl ketones in isopropyl alcohol were subjected to ultraviolet radiation. All the ketones except 3‐methoxy‐2‐pyridyl phenyl ketone were observed to undergo bimolecular reduction to give the corresponding pinacols in 30‐100 percent yields. In cold concentrated sulfuric acid the pinacols were found to rearrange with the exclusive migration of the phenyl group. The pinacols hearing the 3‐pyridyl groups rearranged at a much faster rate than the 2‐pyridyl isomers.
Remotely controlled integrated directional coupler switch (1981)

In this paper experimental results concerning the remote control of a bistable directional coupler switch are reported. It is shown that the output light from the coupler can be switched from one channel to the other via switching information contained in the incident light itself. The principle of operation of the device is demonstrated using a coupler fabricated in an LiNbO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> substrate. A switching time of the order of 100 μs has been obtained, limited only by the electronic feedback loop used in the experiment.
Adifor 2.0: automatic differentiation of Fortran 77 programs (1996)

Numerical codes that calculate not only a result, but also the derivatives of the variables with respect to each other, facilitate sensitivity analysis, inverse problem solving, and optimization. The paper considers how Adifor 2.0, which won the 1995 Wilkinson Prize for Numerical Software, can automatically differentiate complicated Fortran code much faster than a programmer can do it by hand. The Adifor system has three main components: the AdiFor preprocessor, the ADIntrinsics exception-handling system, and the SparsLinC library.
Preliminary crystallographic examination of a novel fungal lysozyme from Chalaropsis. (1990)

The lysozyme from the fungus of the Chalaropsis species has been crystallized. This lysozyme (Mr 22,415) displays no sequence homology with avian, phage, or mammalian lysozymes, however, preliminary studies indicate significant sequence homology with the bacterial lysozyme from Streptomyces. Both enzymes are unusual in possessing beta-1,4-N-acetylmuramidase and beta-1,4-N,6-O-diacetylmuramidase activity. The crystals grow from solutions of ammonium sulfate during growth periods from several months to a year. The space group is P2(1)2(1)2(1) with a = 34.0 A, b = 42.6 A, c = 122.1 A. Preliminary data indicate that there is 1 molecule/asymmetric unit. A complete native data set has been collected to 2.57-A resolution. The crystals are highly ordered and exhibit diffraction patterns to d-spacings less than 1.5 A.
Regulation of TMPRSS6 by BMP6 and iron in human cells and mice (2011)

Mutations in transmembrane protease, serine 6 (TMPRSS6), encoding matriptase-2, are responsible for the familial anemia disorder iron-refractory iron deficiency anemia (IRIDA). Patients with IRIDA have inappropriately elevated levels of the iron regulatory hormone hepcidin, suggesting that TMPRSS6 is involved in negatively regulating hepcidin expression. Hepcidin is positively regulated by iron via the bone morphogenetic protein (BMP)-SMAD signaling pathway. In this study, we investigated whether BMP6 and iron also regulate TMPRSS6 expression. Here we demonstrate that, in vitro, treatment with BMP6 stimulates TMPRSS6 expression at the mRNA and protein levels and leads to an increase in matriptase-2 activity. Moreover, we identify that inhibitor of DNA binding 1 is the key element of the BMP-SMAD pathway to regulate TMPRSS6 expression in response to BMP6 treatment. Finally, we show that, in mice, Tmprss6 mRNA expression is stimulated by chronic iron treatment or BMP6 injection and is blocked by injection of neutralizing antibody against BMP6. Our results indicate that BMP6 and iron not only induce hepcidin expression but also induce TMPRSS6, a negative regulator of hepcidin expression. Modulation of TMPRSS6 expression could serve as a negative feedback inhibitor to avoid excessive hepcidin increases by iron to help maintain tight homeostatic balance of systemic iron levels.
CHRONIC REJECTION IN THE RAT AORTIC ALLOGRAFT (1993)

Synthetic cyclic octapeptide analogues of somatostatin, such as angiopeptin (BIM23014C; AP) inhibit myointimal proliferation in chronically rejecting rabbit and rat allografts and following angioplasty in rabbits. We have investigated the mechanism of angiopeptin inhibition of allograft arteriosclerosis. DA (RT1a) aortic allografts were transplanted to WF (RT1v) recipients, which either received 80 micrograms/kg/day of AP (Alzet mini-pumps, s.c., 0-180 days) or were left untreated. AP administration did not affect the intensity of adventitial inflammation, nor reduced the disappearance of smooth-muscle cell nuclei from the media (media necrosis); however, it reduced their appearance in the intima and intimal thickening. The effect disappeared, however, from the 3rd month onward. In vivo labeling with tritiated thymidine and autoradiograms demonstrated that AP reduced slightly the proliferation of the inflammatory cells in adventitia and of smooth-muscle cells in the media, and reduced strongly and significantly (P < 0.01) the proliferation of smooth-muscle cells in the intima. Analysis of the major chronic-rejection associated eicosanoids from the vascular wall showed that AP had no effect on the release of the pro-inflammatory thromboxane B2 from the allograft. As AP did not reduce the intensity of perivascular inflammation, reduced only slightly the proliferation of inflammatory cells, and did not affect the release of thromboxane B2 from the inflammatory macrophages, it is likely that the AP effect is not directed to the inflammatory cells. As previous in vitro studies have demonstrated that vascular smooth-muscle cells proliferate in response to several growth factors, and as somatostatin analogues are inhibitory to their action, our data suggest that the action of AP on allograft arteriosclerosis is due to a direct effect on smooth-muscle-cell proliferation.
Combined CloudSat‐CALIPSO‐MODIS retrievals of the properties of ice clouds (2010)

In this paper, data from spaceborne radar, lidar and infrared radiometers on the “A‐Train” of satellites are combined in a variational algorithm to retrieve ice cloud properties. The method allows a seamless retrieval between regions where both radar and lidar are sensitive to the regions where one detects the cloud. We first implement a cloud phase identification method, including identification of supercooled water layers using the lidar signal and temperature to discriminate ice from liquid. We also include rigorous calculation of errors assigned in the variational scheme. We estimate the impact of the microphysical assumptions on the algorithm when radiances are not assimilated by evaluating the impact of the change in the area‐diameter and the density‐diameter relationships in the retrieval of cloud properties. We show that changes to these assumptions affect the radar‐only and lidar‐only retrieval more than the radar‐lidar retrieval, although the lidar‐only extinction retrieval is only weakly affected. We also show that making use of the molecular lidar signal beyond the cloud as a constraint on optical depth, when ice clouds are sufficiently thin to allow the lidar signal to penetrate them entirely, improves the retrieved extinction. When infrared radiances are available, they provide an extra constraint and allow the extinction‐to‐backscatter ratio to vary linearly with height instead of being constant, which improves the vertical distribution of retrieved cloud properties.
Continuous Biometric Authentication: Can It Be More Practical? (2010)

Continuous biometric authentication schemes (CBAS) are built around the biometrics supplied by user behavioural characteristics and continuously check the identity of the user throughout the session. The current literature for CBAS primarily focuses on the accuracy of the system in order to reduce false alarms. However, these attempts do not consider various issues that might affect practicality in real world applications and continuous authentication scenarios. One of the main issues is that the presented CBAS are based on several samples of training data either of both intruder and valid users or only the valid users' profile. This means that historical profiles for either the legitimate users or possible attackers should be available or collected before prediction time. However, in some cases it is impractical to gain the biometric data of the user in advance (before detection time). Another issue is the variability of the behaviour of the user between the registered profile obtained during enrollment, and the profile from the testing phase. The aim of this paper is to identify the limitations in current CBAS in order to make them more practical for real world applications. Also, the paper discusses a new application for CBAS not requiring any training data either from intruders or from valid users.
(Symposium on Bacterial Spores: Paper XII) The Sporicidal Properties of Chemical Disinfectants (1970)

Journal Article (Symposium on Bacterial Spores: Paper XII) The Sporicidal Properties of Chemical Disinfectants Get access G. Sykes G. Sykes Microbiology Laboratory, Boots Pure Drug Co. Ltd., Nottingham, England Search for other works by this author on: Oxford Academic Google Scholar Journal of Applied Bacteriology, Volume 33, Issue 1, 1 March 1970, Pages 147–156, https://doi.org/10.1111/j.1365-2672.1970.tb05240.x Published: 01 March 1970
Deregulated inflammatory response in mice lacking the STK/RON receptor tyrosine kinase (1997)

Immune and inflammatory responses must be rightly regulated to maintain a homoeostatic balance between an effective immune response and tissue damage to the host. NO is a principal mediator of many of the cytokine-inducible macrophage activities during a normal cell-mediated immune response. STK, the murine homologue of the human RON receptor tyrosine kinase, is expressed on murine resident peritoneal macrophages. The ligand for STK, macrophage-stimulating protein (MSP), is a serum protein that is activated by members of the coagulation cascade in response to tissue damage. In addition to its potential to induce chemotaxis and phagocytosis of C3bi-coated erythrocytes, MSP has an inhibitory effect on the production of NO by activated peritoneal macrophages in vitro. Here we demonstrate that peritoneal macrophages from mice lacking STK produce elevated levels of NO in response to interferon (IFN)-gamma in a dose-dependent manner, without the need for a co-stimulus. However, production of pro-inflammatory cytokines by activated macrophages from stk -/- mice is unaltered. In vivo, stk -/- mice exhibit increased inflammation in an IFN-gamma-mediated delayed-type hypersensitivity reaction and increased susceptibility to lipopolysaccharide (LPS)-induced endotoxic shock. Furthermore, the levels of NO in the serum of mice injected with LPS are significantly higher than those in control littermates. Nevertheless, the serum levels of IFN-gamma and the intermediate cytokines generated by the inflammatory response, which have previously been shown to play a role in septicaemic shock, do not differ significantly from controls. These data suggest that the STK receptor suppresses NO production, therefore ameliorating the potentially tissue-damaging effects of a cell-mediated immune response, through negative regulation of the IFN-gamma signalling pathway.
Early bioenergetic evolution (2013)

Life is the harnessing of chemical energy in such a way that the energy-harnessing device makes a copy of itself. This paper outlines an energetically feasible path from a particular inorganic setting for the origin of life to the first free-living cells. The sources of energy available to early organic synthesis, early evolving systems and early cells stand in the foreground, as do the possible mechanisms of their conversion into harnessable chemical energy for synthetic reactions. With regard to the possible temporal sequence of events, we focus on: (i) alkaline hydrothermal vents as the far-from-equilibrium setting, (ii) the Wood-Ljungdahl (acetyl-CoA) pathway as the route that could have underpinned carbon assimilation for these processes, (iii) biochemical divergence, within the naturally formed inorganic compartments at a hydrothermal mound, of geochemically confined replicating entities with a complexity below that of free-living prokaryotes, and (iv) acetogenesis and methanogenesis as the ancestral forms of carbon and energy metabolism in the first free-living ancestors of the eubacteria and archaebacteria, respectively. In terms of the main evolutionary transitions in early bioenergetic evolution, we focus on: (i) thioester-dependent substrate-level phosphorylations, (ii) harnessing of naturally existing proton gradients at the vent-ocean interface via the ATP synthase, (iii) harnessing of Na(+) gradients generated by H(+)/Na(+) antiporters, (iv) flavin-based bifurcation-dependent gradient generation, and finally (v) quinone-based (and Q-cycle-dependent) proton gradient generation. Of those five transitions, the first four are posited to have taken place at the vent. Ultimately, all of these bioenergetic processes depend, even today, upon CO2 reduction with low-potential ferredoxin (Fd), generated either chemosynthetically or photosynthetically, suggesting a reaction of the type 'reduced iron → reduced carbon' at the beginning of bioenergetic evolution.
New advances in ultra–stable microwave oscillators (2005)

We present the new advances in ultra-stable microwave oscillators recently obtained at the department LPMO of the Institut FEMTO-ST Besançon. These microwave references are based on Sapphire Whispering Gallery Mode Resonators presenting high-Q factor. Different technologies have been developed with these resonators to fulfill the new requirements in term of phase noise or frequency stability for diverse scientific and technical applications.