gebhart/patrepeval huggingface dataset:
Role of Endogenous Serotonin in Modulating Genioglossus Muscle Activity in Awake and Sleeping Rats (2005)

The results show a minimal endogenous serotonergic drive at the HMN modulating GG activity across sleep-wake states, unless augmented by reflex inputs. This result has implications for pharmacologic strategies aiming to increase GG activity by manipulating endogenous serotonin in patients with obstructive sleep apnea.
Study and Modelization of Veterinary Drug Residue Kinetics on Sawdust as Absorptive Biomaterial in Eastern Algeria during January 2017 to June 2018 (2019)

Sawdust, an affordable resource, is being investigated as an adsorbent to eliminate residual contaminants from water. Wood processing residues such as bark and sawdust have been widely studied for some years for their adsorption and removal properties of toxic metals contained in contaminated effluents. The aim of our study is to know the source of chemical contamination of water by using spectrophotometry methods in field ultraviolet, the kinetic study of sodium salicylate adsorption on sawdust was modelized according to two kinetic models (pseudo first and second order), to determine the most optimal pattern to describe this phenomenon, was based in the comparison on the correlation coefficient (R 2 ) between the absorbance and the wavelength for both models and evaluate the optimal time of contact solid/liquid. Present results indicated that the correlation coefficient (R 2 =0.999) for the pseudo-second order, which means that this model is the best for future studies in the kinetics of adsorption of sodium salicylate by sawdust, with a time of contact solid /liquid optimal is 44.5 minutes.
<title>AlGaN Schottky diodes for short-wavelength UV applications</title> (2001)

High performance ultraviolet (UV) detectors have been fabricated using plasma-enhanced molecular beam epitaxy. The realized AlGaN Schottky detectors exhibit high responsivity, sharp spectral cutoff and high shunt resistance of several giga-ohms for 0.5 mm<SUP>2</SUP> active area devices. Quantitative measurements have been carried out on these detectors in the photon energy range from < 1 to > 10 eV (from approximately 1200 to 120 nm in wavelength). Very short UV spectral measurement of these AlGaN detectors is reported for the first time using high intensity sources. The detectors exhibited almost eight orders of magnitude in response dynamic range in that spectral span. Reliability of the devices is evaluated after exposure to repeated DUV irradiation.
Interplay between Estrogen Response Element Sequence and Ligands Controls in Vivo Binding of Estrogen Receptor to Regulated Genes (2004)

To examine the role of the estrogen response element (ERE) sequence in binding of liganded estrogen receptor (ER) to promoters, we analyzed in vivo interaction of liganded ER with the imperfect ERE in the pS2 gene and the composite estrogen-responsive unit (ERU) in the proteinase inhibitor 9 (PI-9) gene. In transient transfections of ER-positive HepG2-ER7 cells, PI-9 was strongly induced by estrogen, moxestrol (MOX), and 4-hydroxytamoxifen (OHT). PI-9 was not induced by raloxifene or ICI 182,780. Quantitative reverse transcriptase-PCR showed that moxestrol strongly induced cellular PI-9 and pS2 mRNAs, whereas OHT moderately induced PI-9 mRNA and weakly induced pS2 mRNA. Chromatin immunoprecipitation experiments demonstrated strong and similar association of 17beta-estradiol-hERalpha and MOX-hERalpha with the PI-9 ERU and with the pS2 ERE. Binding of MOX-hERalpha to the PI-9 ERU and the pS2 ERE was rapid and continuous. Although MOX-hERalpha bound strongly to the PI-9 ERU and less well to the pS2 ERE in chromatin immunoprecipitation, gel shift assays showed that estrogen-hERalpha binds with higher affinity to the deproteinized pS2 ERE than to the PI-9 ERU. Across a broad range of OHT concentrations, OHT-hERalpha associated strongly with the pS2 ERE and weakly with the PI-9 ERU. ICI-hERalpha bound poorly to the PI-9 ERU and effectively to the pS2 ERE. Raloxifene-hERalpha and MOX-hERalpha exhibited similar binding to the PI-9 ERU and the pS2 ERE. These studies demonstrate that ER ligand and ERE sequence work together to regulate in vivo binding of ER to estrogen-responsive promoters.
Clinical and biochemical correlations in mitochondrial myopathies treated with coenzyme Q <sub>10</sub> (1988)

We tested the efficacy of coenzyme Q10 (ubidecarenone, CoQ10) therapy in patients with Kearns-Sayre syndrome and other mitochondrial myopathies with chronic progressive external ophthalmoplegia (CPEO). We treated seven patients for 1 year with daily oral administration of 120 mg of CoQ10. Throughout the treatment most of our patients showed a progressive reduction of serum lactate and pyruvate levels following standard muscle exercise and generally improved neurologic functions. The ECG and echocardiogram showed no significant changes in our patients. None of our patients showed any improvement in ptosis and CPEO.
Immunization of suckling pigs against enteric enterotoxigenic Escherichia coli infection by vaccinating dams with purified pili (1978)

Pregnant swine (gilts) were vaccinated parenterally with a suspension of purified pili from the porcine enterotoxigenic Escherichia coli strain 987 (09:K103::NM). Gilts injected with placebo served as controls. Suckling pigs born to gilts in both groups were challenged intragastrically with virulent strain 987. The percentage of deaths, incidence and duration of diarrhea, numbers of E. coli in the ilea, and E. coli attachment to the villous epithelia were significantly less in suckling pigs of vaccinated gilts than in those of controls. These results are consistent with the hypothesis that pili of some enterotoxigenic E. coli facilitate adhesion to intestinal epithelia. Vaccination of dams with pili appears to be a means of immunizing against diarrheal disease caused by enterotoxigenic E. coli in suckling neonates. This work confirms the role of somatic pili as colonization and virulence factors and provides another example of safe and effective purified pilus vaccines.
Doped Hf0.5Zr0.5O2 for high efficiency integrated supercapacitors (2017)

Applications for integrated energy storage and pulse-power devices may have found opportunities in the emergence of the ferroelectric hafnium-zirconium oxide thin film system. To explore the boundaries of this material thin film system, 10 nm thick binary Hf0.5Zr0.5O2 (HZO) thin films are doped with Al or Si (Al or Si-doped HZO). The added dopants provide a distinct shift in behavior from ferroelectric to antiferroelectric characteristics. Si-doped Hf0.5Zr0.5O2 thin films exhibited a larger than 50 J/cm3 energy storage density with an efficiency of over 80%. The Si-doped Hf0.5Zr0.5O2 thin films were cycled 109 times up to 125 °C and maintained a robust 35 J/cm3 energy storage density and greater than 80% efficiency. Al-doped Hf0.5Zr0.5O2 thin films exhibited a larger switching field, leading to a smaller energy storage density and less robust cycling properties than Si-doped Hf0.5Zr0.5O2.
<title>Inorganic Compound Speciation By Fourier Transform Infrared (FTIR)</title> (1981)

FT-IR offers a unique method of inorganic compound speciation. Particularily in environmental samples, inorganic information has previosuly been limited to elemental or at best anion/cation information. Using FT-IR, a relatively small amount of sample (about 1 mg) can yield inorganic compound identifications. Of central importance to this technique is the availability of a good computerized reference library of pure inorganic compounds in common hydration states. This library should cover both mid- and far IR. In our laboratory, this library is being amassed using X-ray crystallography to comlement infrared results. A computer search system for the identification of inorganic compounds in mixtures has been developed which uses the above library as well as spectral knowledge of the user. Second derivative spectra are used to establish exact peak frequencies. The combination of good reference spectra and the ability to locate the exact position of overlapping bands by the use of the 2nd derivative, allows the identification of specific inorganic compounds in complex mixtures.
Solubility of a bone-inducing substance from a murine osteosarcoma. (1984)

A bone-inducing substance (osteogenic factor) from a murine osteosarcoma was found to be soluble in 1% sodium lauryl sulfate (SDS), 1% deoxycholate, 1% Triton X-100, and 1% Nonidet P-40. A precipitate formed on removal of the detergents by dialysis against phosphate buffer, and this precipitate induced ectopic bone formation when implanted into allogeneic mice. The insoluble residue left after extraction with SDS or deoxycholate did not evoke new bone formation, indicating that the substance was solubilized completely. The bone-inducing substance was also partially solubilized with weak acids (pH, 2.6-3.0) but not with acidic solutions of lower or higher pH. These findings indicate that the solubility of the substance depends on the hydrogen ion concentration of the solution. The substance was not solubilized with EDTA or 6 M urea.
cw diode pumped 2.3 μm fiber laser (1989)

We report the first successful operation of a diode pumped continuous-wave (cw) thulium-doped fluorozirconate fiber laser at 2.3 μm. Output power of 1 mW and slope efficiency of 10% are demonstrated. Saturation effects limiting efficiency are observed and discussed.
Blocking enzyme-linked immunosorbent assay for detection of antibodies to Actinobacillus pleuropneumoniae serotype 2 (1991)

A blocking enzyme-linked immunosorbent assay (ELISA), based upon a polyclonal rabbit antiserum specific to Actinobacillus pleuropneumoniae serotype 2, was developed for the detection of antibodies to A. pleuropneumoniae serotype 2 in pigs. By testing sera from pigs experimentally infected with the 11 recognized serotypes of A. pleuropneumoniae, the assay was proven to be specific for A. pleuropneumoniae serotype 2. With field sera from herds infected with A. pleuropneumoniae serotype 2, the assay was found to be more sensitive than the complement fixation test. Positive results were not observed with field sera from herds known to be free from Actinobacillus infection or with sera from two herds infected with either A. pleuropneumoniae serotype 6 or 8. The high diagnostic sensitivity and specificity of the blocking ELISA will make it useful in field diagnostic work.
A Quartz Resonator Pressure Transducer (1969)

A digital pressure transducer has been developed utilizing a precision 5 MHz piezoelectric quartz resonator. The circular resonator exhibits linear changes in frequency when subjected to radial compressive stresses. A cylindrical quartz tube, integral with the circular resonator, acts as a diaphragm and transfers and concentrates the stress from the applied pressure onto the periphery of the resonator. Since the tube and resonator are fabricated from a single quartz crystal, nonelastic effects are minimized. The transducer has a dynamic range of 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">7</sup> and a pressure range of 0 to 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sup> psia.
The biomechanical evaluation of calcium phosphate cements for use in vertebroplasty (2006)

The CaP3-injected vertebrae restored the MCLs of human vertebrae closer to their initial levels than the PMMA-injected vertebrae did. The CaP2- and CaP3-injected PSUs showed no tendency to induce compression fractures in adjacent VBs.
Magnetic nanoparticles and a magnetic field for the rapid removal of device related infections (2011)

The purpose of this study was to develop materials and a method to kill bacteria, separating them from solution, using superparamagnetic iron oxide nanoparticles (SPION) coated with various antibacterials including iron, zinc, and silver. It was found that such coated SPION alone kill bacteria, and reduce biofilm formation (which is an important mode of antibiotic resistance in device related infections). With the aid of a magnet, these antibacterial properties could be manipulated and improved, potentially providing a new method for treating antibiotic resistant device related infections.
Gross anatomy, myoarchitecture, and ultrastructure of the heart ventricle in the haemoglobinless icefish <i>Chaenocephalus aceratus</i> (1991)

The gross and microscopic anatomy of the heart ventricle in the haemoglobinless icefish Chaenocephalus aceratus is described. The ventricle is saclike in shape and has a relative mass approximately three times greater than that of related "red-blooded" Antarctic fish. The myocardium in C. aceratus is entirely trabecular and consists of myocytes, granulated noncontractile cells, and electron-dense interstitial spaces. Blood supply is through the venous lacunary circuit. In addition, two size classes of channels occur in the subepicardium, with mean diameters of 15 and 50 μm. The larger channels are connected directly with the intertrabecular spaces. The volume density of mitochondria is 0.47 in icefish myocytes, 0.15 in those of a tropical fish (Astronotus ocellatus) with a myoglobin-rich ventricle, and 0.27 in a cold-temperate fish (Cyclopterus lumpus) with a myoglobin-poor ventricle. The volume density of myofibrils in C. aceratus (0.25) is significantly less than in A. ocellatus (0.45) and C. lumpus (0.42). The data obtained are discussed in relation to present knowledge about the function of the heart in C aceratus as a low-speed, large-volume pump.
Maximum likelihood 3-D near-field source localization using the EM algorithm (2004)

In this paper, maximum likelihood estimator is proposed for passive localization of narrowband sources in the spherical coordinates (azimuth, elevation, range). We adapt expectation/maximization iterative method to solve the complicated multi-parameter optimization problem appearing on the 3-D localization problem. The proposed algorithm is based on maximum likelihood criterion, which employs the source signals recorded by 2-D array under near-field assumption. Expectation/maximization algorithm decomposes the observed data into its components and then estimates the parameters of each signal component separately providing computationally efficient solution to the resulting optimization problem. Finally, some numerical simulations illustrate the applicability and effectiveness of the proposed algorithm.
A simple QoS signaling protocol for mobile hosts in the integrated services Internet (1999)

With advances in packet routing technology, and resource reservation protocols, the Internet is expected to provide ubiquitous integrated transport of speech, audio, video, and other real-time multimedia data in addition to the current best effort data traffic. Such integrated transport will also need to be supported for the increasing number of mobile users who access the Internet over wireless access networks, using Mobile-IP to retain continual IP connectivity. We present a simple quality of service (QoS) signaling protocol for mobile users in an integrated service Internet. The protocol works by combining pre-provisioned RSVP tunnels with Mobile IP. Our protocol, even-though simple, captures the essence of QoS provisioning for wireless and mobile networks. The wireless medium provides a completely different medium than wires, and therefore one's expectations from it should be different. Service quality is inherently mobility dependent, and intermittent disconnections are bound to happen. It is not the signaling protocol's task to completely overcome or conceal transient conditions from applications, but rather applications should try to adapt. Our approach can be easily implemented today with minimal changes to other components of the Internet architecture. We also evaluate the application level performance impact of the QoS provisioning delays associated with our protocol on a prototypical packet speech application with various playout buffering strategies, and compare against the performance of the ordinary RSVP protocol suite with Mobile IP.
A 16 384-bit dynamic RAM (1976)

A 16-kbit dynamic RAM is described which is TTL compatible on all pins, and fits a standard 16-pin package. A single-transistor storage cell is used which occupies 455 /spl mu/m/SUP 2/. The device is fabricated in n-channel two-layer polysilicon gate technology using conventional design rules. The chip size is 145 by 234 mils. A low-power sense amplifier is used for each 64 memory cells. A special refresh mode is possible in which all 256 sense amplifiers are active, and the entire memory can be refreshed in 64 address cycles.
Porcine relaxin. Gene structure and expression. (1987)

A porcine genomic cosmid library was constructed to study the structure and regulation of the porcine relaxin gene. Two overlapping cosmids containing relaxin-specific sequences were isolated, and a 9-kilobase BamHI fragment containing the porcine relaxin gene was sequenced. The sequence derived from these cosmids was used to characterize the relaxin gene transcription unit utilized in the pregnant ovary. Analysis of chromosomal and cosmid DNA has shown that porcine relaxin is encoded by a single copy gene, comprising two exons separated by a 5.5-kilobase intron. The gene contains elements representing two classes of repeated sequences homologous with the human Alu and Kpn families. The transcriptional initiation site of this gene was located by primed extension and direct sequencing of relaxin-specific cDNA. Furthermore, the promoter elements were mapped and sequenced, and transcriptional activity was demonstrated. The promoter contained sequences with homology to regions conserved within retroviral long terminal repeats and within the adenovirus E4 promoter.
Anomaly Detection Using DSNS and a Dependency Graph for SNMP Objects (2008)

This paper addresses the problem of detecting anomalies in computer networks. Anomalies are significant changes in traffic levels, which can cause grave consequences to the execution of services offered by the network. The main characteristics of the anomaly detection system proposed in this work are: (i) application of the DSNS (Digital Signature of Network Segment), in order to detect the traffic behavior deviations. (ii) application of a dependency graph that represents the relations between the SNMP objects, in order to correlate the alarms generated for different objects. The results obtained from initial tests performed in a real environment were encouraging. They showed that our system is able to detect anomalies on the monitored network elements, avoiding the high false alarms rate.
Medical treatment of cataract (2007)

The incidence of cataract continues to increase with the ageing of the population. Surgical treatment with phacoemulsification and intraocular lens implantation remains the only proven treatment. This, however, is associated with significant cost and is not readily available especially in the developing countries where the prevalence of cataract is the highest. Medical treatment of cataract is therefore a highly desired alternative. Since the last major review of medical treatment of cataract the search for an anti-cataract agent has advanced on many fronts. Some anti-cataract drugs, such as carnosine, have now reached clinical trials and showed encouraging results that warrant further investigation. The discovery of an effective medical treatment for cataract is likely to make global impact on eye health. The aims of this paper are to review the literature on the drug therapy of cataract and provide updates of the latest development.
Intravenous immunoglobulin and thymoglobulin facilitate kidney transplantation in complement-dependent cytotoxicity B-cell and flow cytometry T- or B-cell crossmatch-positive patients (2003)

Our results indicate that i.v.IG and Thymoglobulin induction treatment may facilitate kidney transplantation in B-cell CDC and T- or B-cell FC crossmatch-positive patients.
An RFID System with Fully Integrated Transponder (2007)

This paper presents an RFID system with fully integrated transponder. The transmit path of the reader as well as key blocks of the tag is designed and fabricated in standard CMOS 0.18μm process. The system operates at 900MHz with the coverage range of more than 0.4cm. The tag's antenna is integrated on chip without using any special process. The reader employs a coil switching technique to increase its coverage area. The PA in the transmit path of the reader is designed using digital to RF configuration. By employing a proper output network, the PA can deliver a current of 225mA (RMS) to the reader's coil.
SVM Based P2P Traffic Identification (2010)

The rapid growth of p2p technology has enriched application forms of network,at the same time,it also brings many security problems to the network management.Research on P2P flow identification has become the most important problem of P2P flow management.Paper proposed a method to realize the P2P network traffic classification based on the SVM.This method uses SVM method based on the statistical theory and analyzes the characteristics of network traffic to classify the different P2P traffic application,the average precise rate is 92.2%.
The norepinephrine‐driven metastasis development of PC‐3 human prostate cancer cells in BALB/c nude mice is inhibited by β‐blockers (2005)

The development of metastases is a decisive step in the course of a cancer disease. The detection of metastases in cancer patients is correlated with a poor prognosis, and over 90% of all deaths from cancer are not due to the primary tumor, which often can be successfully treated, but are due to the metastases. Tumor cell migration, a prerequisite for metastasis development, is not merely genetically determined, but is distinctly regulated by signal substances of the environment including chemokines and neurotransmitters. We have shown previously that the migration of breast, prostate, and colon carcinoma cells is enhanced by the stress-related neurotransmitter norepinephrine in vitro, and that this effect can be inhibited by the beta-blocker propranolol. We now provide for the first time evidence for the in vivo relevance of this neurotransmitter-driven regulation using PC-3 prostate carcinoma cells. The development of lumbar lymph node metastases in athymic BALB/c nude mice increased with the application of norepinephrine via microosmotic pumps, while propranolol inhibited this effect. However, the growth of the primary tumor was not affected by either treatment. Additionally, experiments using human tissue microarrays showed that 70-90 percent of breast, colon, and prostate carcinoma tissues express the relevant beta2-adrenoceptor. Thus, our work contributes to the understanding of the basic cellular mechanisms of metastasis development, and furthermore delivers a rationale for the chemopreventive use of clinically established beta-blockers for the inhibition of metastases.