gebhart/patrepeval huggingface dataset:
Purification and characterization of GDP-L-fucose-N-acetyl beta-D-glucosaminide alpha 1—-6fucosyltransferase from cultured human skin fibroblasts. Requirement of a specific biantennary oligosaccharide as substrate. (1991)

GDP-L-fucose-N-acetyl-beta-D-glucosaminide alpha 1----6fucosyltransferase which catalyzes the transfer of fucose from GDP-L-fucose to the asparagine-linked N-acetyl-beta-D-glucosamine of N-linked glycoproteins has been purified 37,000-fold from cultured human skin fibroblasts. The Km values for the substrate asialoagalactotransferrin glycopeptide, and GDP-L-fucose were 66 and 4.2 microM, respectively. The Vmax was 1.4 mumols/mg/min. The key step in enzyme purification was affinity chromatography using the immobilized substrate asialoagalactotransferrin glycopeptide-CH-Sepharose. The affinity-purified enzyme had a minimum substrate requirement for a biantennary oligosaccharide with GlcNAc in terminal position, having a Km value of 55 microM. It was heretofore unexpected that the oligosaccharide would serve as substrate, since the site of enzyme activity is GlcNAc-1-linked to Asn. Although the presence of amino acids on this oligosaccharide enhanced the activity 3-fold, it is proposed that this may be the result of an alpha/beta anomeric mixture (2:1) of oligosaccharide used in these studies with only the beta anomer active as substrate. The implication is that the amino acid is required only to retain the beta anomeric position of the substrate. Removal of GlcNAc or addition of Gal to either the oligosaccharide or glycopeptide destroyed the ability to serve as substrates. In addition, di-N-acetylchitobiose, tri-N-acetylchitotriose and GlcNAc beta 1----Asn were nonpermissible substrates. This rigid substrate requirement is unique among fucosyltransferases thus far reported, since the natural substrates for the other enzymes may be substituted by one of several disaccharides.
Electrical Properties of Carbon Nanotube Based Fibers and Their Future Use in Electrical Wiring (2014)

The production of continuous fibers made purely of carbon nanotubes has paved the way for new macro‐scale applications which utilize the superior properties of individual carbon nanotubes. These wire‐like macroscopic assemblies of carbon nanotubes were recognized to have a potential to be used in electrical wiring. Carbon nanotube wiring may be extremely light and mechanically stronger and more efficient in transferring high frequency signals than any conventional conducting material, being cost‐effective simultaneously. However, transfer of the unique properties of individual CNTs to the macro‐scale proves to be quite challenging. This Feature Article gives an overview of the potential of using carbon nanotube fibers as next generation wiring, state of the art developments in this field, and goals to be achieved before carbon nanotubes may be transformed into competitive products.
An unusual cationic Ru(ii) indenylidene complex and its Ru(iii) derivative—efficient catalysts for high temperature olefinmetathesis reactions (2011)

The use of a mixed phosphite/N-heterocyclic carbene bearing ruthenium precursor permits the synthesis and characterisation of unprecedented four-coordinate Ru(II) and Ru(III) cationic complexes adopting an unusual sawhorse structure. The cationic Ru(II) complex performs very effectively on challenging substrates at high temperature in very short reaction times and low catalyst loadings.
Effects of intermittent intraperitoneal infusion of salmon calcitonin on food intake and adiposity in obese rats (2007)

Chronic administration of anorexigenic substances to experimental animals by injections or continuous infusion typically produces no effect or a transient reduction in daily food intake and body weight. Our aim was to identify an intermittent dosing strategy for intraperitoneal infusion of salmon calcitonin (sCT), a homolog of amylin that produces a sustained 25-35% reduction in daily food intake and adiposity in diet-induced obese rats. Rats (649 +/- 10 g body wt, 27 +/- 1% body fat), with intraperitoneal catheters tethered to infusion swivels, had free access to a 45% fat diet. Food intake, body weight, and adiposity during the 7-wk test period were relatively stable in the vehicle-treated rats (n = 16). None of 10 sCT dosing regimens administered in succession to a second group of rats (n = 18) produced a sustained 25-35% reduction in daily food intake for >5 days, although body weight and adiposity were reduced by 9% (587 +/- 12 vs. 651 +/- 14 g) and 22% (20.6 +/- 1.2 vs. 26.5 +/- 1.1%), respectively, across the 7-wk period. The declining inhibitory effect of sCT on daily food intake with the 6-h interinfusion interval appeared to be due in part to an increase in food intake between infusions. The declining inhibitory effect of sCT on daily food intake with the 2- to 3-h interinfusion interval suggested possible receptor downregulation and tolerance to frequent sCT administration; however, food intake increased dramatically when sCT was discontinued for 1 day after apparent loss of treatment efficacy. Together, these results demonstrate the activation of a potent homeostatic response to increase food intake when sCT reduces food intake and energy reserves in diet-induced obese rats.
A Stable Network-Aware VM Placement for Cloud Systems (2012)

Virtual Machine (VM) placement has to carefully consider the aggregated resource consumption of co-located VMs in order to obey service level agreements at lower possible cost. In this paper, we focus on satisfying the traffic demands of the VMs in addition to CPU and memory requirements. This is a much more complex problem both due to its quadratic nature (being the communication between a pair of VMs) and since it involves many factors beyond the physical host, like the network topologies and the routing scheme. Moreover, traffic patterns may vary over time and predicting the resulting effect on the actual available bandwidth between hosts within the data center is extremely difficult. We address this problem by trying to allocate a placement that not only satisfies the predicted communication demand but is also resilient to demand time-variations. This gives rise to a new optimization problem that we call the Min Cut Ratio-aware VM Placement (MCRVMP). The general MCRVMP problem is NP-Hard, hence, we introduce several heuristics to solve it in reasonable time. We present extensive experimental results, associated with both placement computation and run-time performance under time-varying traffic demands, to show that our heuristics provide good results (compared to the optimal solution) for medium size data centers.
Current Topics in Pharmacological Research on Bone Metabolism: Regulation of Bone Mass by the Function of Endogenous Modulators of Bone Morphogenetic Protein in Adult Stage (2006)

Bone formation in adults determines the basic mass of bone and hence it is crucial to understand the mechanisms of its regulation. As remodeling is proceeding, bone resorption is determined by the physical conditions. Especially in women, postmenopausal bone loss is characterized by rapid bone loss due to increase in bone resorption and relative negative balance between such bone resorption and accelerated bone formation. Bone formation is also critical in considering measures to treat patients with very low bone mass. In these subjects, simple suppression of bone resorption would not be enough to maintain bone mass. Thus, bone formation in the adult is of importance in terms of both pathological and therapeutic aspects. This review addresses the possible roles of bone formation modulators in the maintenance of bone mass in the light of understanding the determination of adult bone mass.
A phase I, first-in-human, open-label, dose-escalation, safety, pharmacokinetic, and pharmacodynamic study of oral TP-3654 administered daily for 28 days to patients with advanced solid tumors. (2020)

3586 Background: TP-3654 is an oral, second generation, potent PIM-1 kinase inhibitor with activity against PIM 2, 3 and favorable selectivity against other kinases. These cytoplasmic serine/threonine kinases are highly expressed in many cancers and their oncogenic potential has been largely attributed to supressing apoptosis downstream of stimuli including inflammatory cytokines and other immune effectors. TP-3654 has efficacy in various hematologic and solid tumor models inducing stromal Pim-1 also has been shown to mediate various aspects of the tumor microenvironment. Thus, Pim kinases are attractive targets for the treatment of many human malignanices. Methods: A first in human, multicenter, phase 1, dose escalation study using a standard 3+3 design with a modified Fibonacci scheme to examine the safety and clinical activity of TP-3654 in patients with advanced solid tumors. Results: Ten patients were enrolled between 30Apr and 31Dec2019 receiving 480, 720, and 1080 mg respectively. Grade 3 AEs were scrotum wound infection, altered mental status, anemia, fall, and lower extremity edema, none were related to study drug and all were manageable with supportive care. There were no Grade 4 or 5 AEs and no DLTs. Median duration of SD was 5.5 months (6/10) and with prolonged SD > 16wks (4/10). One CRC patient with 4 lines of prior therapy had a 22% reduction in tumor volume (SD > 5+ mos). TP-3654 plasma PK values (C max , AUC) continuously increased through all 3 cohorts. Average C max (ng/mL) and AUC 0-24 (ng*hours/mL) were 195, 1965 (480mg); 357, 3310 (720mg); 735, 6922 (1080mg), respectively. PK values increased linearly with higher doses without reaching saturation. Peripheral Blood Mononuclear Cells were isolated from subjects prior and up to 24hours after treatment. Western Blot from protein lysates revealed a decrease in phosphorylation of BAD and p70s6K proteins, both regulated by PIM-1 kinase. Conclusions: These findings suggest that TP-3654 is tolerated as a monotherapy in patients with heavily pretreated, relapsed, and resistant solid tumors warranting further clinical development in selected indications.
Tactons: structured tactile messages for non-visual information display (2004)

Tactile displays are now becoming available in a form that can be easily used in a user interface. This paper de-scribes a new form of tactile output. Tactons, or tactile icons, are structured, abstract messages that can be used to communicate messages non-visually. A range of differ-ent parameters can be used for Tacton construction in-cluding: frequency, amplitude and duration of a tactile pulse, plus other parameters such as rhythm and location. Tactons have the potential to improve interaction in a range of different areas, particularly where the visual dis-play is overloaded, limited in size or not available, such as interfaces for blind people or in mobile and wearable de-vices..This paper describes Tactons, the parameters used to construct them and some possible ways to design them. Examples of where Tactons might prove useful in user interfaces are given.
Stateful Reconfigurable Logic via a Single-Voltage-Gated Spin Hall-Effect Driven Magnetic Tunnel Junction in a Spintronic Memory (2017)

Stateful in-memory logic (IML) is a promising paradigm to realize the unity of data storage and processing in the same die, exhibiting great feasibility to break the bottleneck of the conventional von Neumann architecture. On the roadmap toward developing such a logic platform, a critical step is the effective and efficient realization of a complete set of logic functions within a memory. In this paper, we report a realization of stateful reconfigurable logic functions via a single three-terminal magnetic tunnel junction (MTJ) device within a spintronic memory by exploiting the novel voltage-gated spin Hall-effect driven magnetization switching mechanism. This proposed reconfigurable IML methodology can be implemented within either a typical memory array or a cross-point array architecture. The feasibility of the proposed approach is successfully demonstrated with hybrid MTJ/CMOS circuit simulations. We believe our work may promote the research and development of the revolutionary IML for future non-von Neumann architectures.
VISIBLE LIGHT PHOTOCHEMICAL RELEASE OF NITRIC OXIDE FROM <i>S</i>‐NITROSOGLUTATHIONE: POTENTIAL PHOTOCHEMOTHERAPEUTIC APPLICATIONS (1994)

Some aspects of the physiological role of NO may be mediated by stable NO-carriers such as S-nitrosoglutathione and related S-nitrosothiols. In this report we show that irradiation of S-nitrosoglutathione at either absorption band (lambda max = 340 nm or 545 nm) results in the release of nitric oxide. Photolysis of S-nitrosoglutathione at 545 nm exhibited a quantum yield of 0.056 +/- 0.002 and was best approximated by a first-order process with kobs = 4.9 x 10(-7) +/- 0.3 x 10(-7) s-1. The photolytic release of NO from S-nitrosoglutathione resulted in an enhanced cytotoxic effect of S-nitrosoglutathione on HL-60 leukemia cells. That the cytotoxic effect of S-nitrosoglutathione was diminished by the addition of oxyhemoglobin strongly suggests that NO is the cytotoxic species. The finding that NO can be readily liberated from S-nitrosoglutathione by visible radiation indicates that the photochemical properties of this compound in the visible spectrum must be considered in order to obtain meaningful data as to its physiological role and the S-nitrosoglutathione and related compounds may find use as photochemotherapeutic agents.
Accuracy and Safety in Pedicle Screw Placement in the Thoracic and Lumbar Spines : Comparison Study between Conventional C-Arm Fluoroscopy and Navigation Coupled with O-Arm® Guided Methods (2012)

The screw placement under the navigation-guidance coupled with O-arm® system appears to be more accurate and safer than that under the fluoroscopy guidance, although the preparation and screwing time for the navigation-guided surgery is longer than that for the fluoroscopy-guided surgery.
Genetic and Environmental Determinants of 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D Levels in Hispanic and African Americans (2008)

SNPs in the DBP are associated with levels of 25(OH)D and 1,25(OH)2D in HA and AA participants in the Insulin Resistance Atherosclerosis Family Study.
The laboratory rat as an animal model for osteoporosis research. (2008)

Osteoporosis is an important systemic disorder, affecting mainly Caucasian women, with a diverse and multifactorial etiology. A large variety of animal species, including rodents, rabbits, dogs, and primates, have been used as animal models in osteoporosis research. Among these, the laboratory rat is the preferred animal for most researchers. Its skeleton has been studied extensively, and although there are several limitations to its similarity to the human condition, these can be overcome through detailed knowledge of its specific traits or with certain techniques. The rat has been used in many experimental protocols leading to bone loss, including hormonal interventions (ovariectomy, orchidectomy, hypophysectomy, parathyroidectomy), immobilization, and dietary manipulations. The aim of the current review is not only to present the ovariectomized rat and its advantages as an appropriate model for the research of osteoporosis, but also to provide information about the most relevant age and bone site selection according to the goals of each experimental protocol. In addition, several methods of bone mass evaluation are assessed, such as biochemical markers, densitometry, histomorphometry, and bone mechanical testing, that are used for monitoring and evaluation of this animal model in preventive or therapeutic strategies for osteoporosis.
Effects of pramlintide, an amylin analogue, on gastric emptying in type 1 and 2 diabetes mellitus (2002)

Pramlintide delays gastric emptying, possibly by a centrally mediated mechanism. Our aim was to determine whether the effects of pramlintide on gastric emptying differ in people with type 1 or type 2 diabetes who had no history of complications. Using a randomized, three-period, two-dose, crossover design, we studied the effects of 0, 30, or 60 microg t.i.d. pramlintide subcutaneously for 5 days each in six type 1 and six type 2 diabetic subjects. Gastric emptying of solids was measured by 13C-Spirulina breath test. Plasma pancreatic polypeptide (HPP) response to the test meal was also measured. Relative to placebo [t 50% 91 +/- 6 min (means +/- SEM)], pramlintide equally delayed gastric emptying following 30 or 60 microg t.i.d. (268 +/- 37 min, 329 +/- 49 min, respectively; P < 0.01]. Postprandial HPP levels were lower in response to 30 and 60 microg pramlintide compared to placebo. There were no significant differences in the effects on gastric emptying or HPP levels between type 1 and type 2 diabetic subjects. Pramlintide delays gastric emptying in diabetes unassociated with clinically detected complications. Further studies are needed in diabetic patients with impaired gastric motor function.
A multi-mission space avionics architecture (2002)

As the budget for the space industry is dwindling, a reusable avionics architecture applicable across multiple missions is urgently needed to reduce the development and production costs of flight projects. This paper presents a multi-mission avionics architecture which employs interface standards extensively, so that avionics systems can be built rapidly by assembling subsystems and instruments in a plug-and-play manner. The key feature of this architecture is a "backbone" standard parallel bus which can accommodate various standard interfaces through a repertoire of I/O modules. Hence, specific mission requirements can be met by selecting and integrating the appropriate subsystems and instruments into the system. This architecture can also adopt different "backbone" buses, implement redundant processors, and support distributed processing. An example of the architecture using the MOPS6000 (Miniaturized Optimized Processor for Space-RAD6000) is also described.
A Word Embedding Approach to Predicting the Compositionality of Multiword Expressions (2015)

This paper presents the first attempt to use word embeddings to predict the compositionality of multiword expressions. We consider both single-and multi-prototype word embeddings. Experimental results show that, in combination with a back-off method based on string similarity, word embeddings outperform a method using count-based distributional similarity. Our best results are competitive with, or superior to, state-of-the-art methods over three standard compositionality datasets, which include two types of multiword expressions and two languages.
The potential role of vitamin E in the treatment of immunologic abnormalities during acquired immune deficiency syndrome. (1991)

The literature is briefly summarized as to immunologic modifications caused by the human acquired immune deficiency syndrome (AIDS), immunocompetence at various nutritional states of vitamin E, and the immunoenhancing properties of vitamin E. The abnormalities of immune components present in AIDS are similar to those that are stimulated or restored by intake of high doses of vitamin E. Dietary supplementation of vitamin E with an adequate nutrition support or concomitant use of this vitamin with current drug therapies [For example, Zidovudine (AZT)] may increase the therapeutic efficiency of drugs and enhance immune resistance to opportunistic infections associated with AIDS. Supplementation with vitamin E may also decrease the progression of the disease to AIDS. Unlike many pharmacological agents which are toxic at low levels, vitamin E is non-toxic over a wide range of intakes. A moderately high dose may be used to target and stimulate some specific immune cells destroyed by HIV infection. However, further interdisciplinary studies are much needed to relate various levels of intake of this vitamin as a supplement to clinical outcomes during HIV infection and establish the role for this vitamin in human immunity during AIDS.
Normal Integration: A Survey (2017)

The need for efficient normal integration methods is driven by several computer vision tasks such as shape-from-shading, photometric stereo, deflectometry, etc. In the first part of this survey, we select the most important properties that one may expect from a normal integration method, based on a thorough study of two pioneering works by Horn and Brooks [28] and by Frankot and Chellappa [19]. Apart from accuracy, an integration method should at least be fast and robust to a noisy normal field. In addition, it should be able to handle several types of boundary condition, including the case of a free boundary, and a reconstruction domain of any shape i.e., which is not necessarily rectangular. It is also much appreciated that a minimum number of parameters have to be tuned, or even no parameter at all. Finally, it should preserve the depth discontinuities. In the second part of this survey, we review most of the existing methods in view of this analysis, and conclude that none of them satisfies all of the required properties. This work is complemented by a companion paper entitled Variational Methods for Normal Integration, in which we focus on the problem of normal integration in the presence of depth discontinuities, a problem which occurs as soon as there are occlusions.
The Synthesis of β,γ‐ and α,β‐Unsaturated Aldehydes via Polyene Epoxides (1980)

Abstract A substitute for the Darzens glycidic ester synthesis for converting unsaturated ketones or aldehydes into the homologated β,γ‐ or α,β‐unsaturated aldehydes employing sulfur ylides is described. The carbonyl group is converted into the unsaturated oxirane which is then rearranged to the new aldehyde. High yields of isomerically pure aldehydes are available by this method and the process is of practical importance in the conversion of β‐ionone into the β‐C 14 ‐aldehyde, a key intermediate in the Isler synthesis of vitamin A. The efficient preparation of α‐ and β‐cyclocitral by the novel process is also described.
Mechanism of global functional recovery despite sustained postischemic regional stunning. (1992)

BACKGROUNDThe mechanisms whereby reperfusion of a 20-minute coronary occlusion result in global functional recovery despite persistent regional dysfunction were studied in 11 open-chest reflex-blocked dogs.METHODS AND RESULTSPressure-volume and pressure-thickness relations were simultaneously determined before, during, and after reperfusion of left anterior descending artery (LAD) occlusion. Wall thickness was determined by sonomicrometry in both ischemic and remote regions. Chamber systolic function was assessed by end-systolic pressure-volume relations (ESPVR) obtained by conductance catheter and defined by a slope (Ees) and volume shift at a common end-systolic pressure (delta Ves). LAD occlusion produced regional systolic thinning (-7 +/- 6%) and global left ventricular dysfunction (ESPVR shifted rightward (delta Ves = +8.6 +/- 5.1 ml, p less than 0.001) with no Ees change). After nearly 1 hour of reperfusion, LAD region thickening remained markedly reduced at 4 +/- 7% (versus 23 +/- 8%, control), yet...
A Study on a Lane Detection and Tracking Algorithm Using B-Snake (2005)

In this paper, we propose lane detection and trackinB algerian using B-Snake as robust algorithm. One of chief virtues of Lane detection algorithm using B-Snake is that it is possible to specify a wider range of lane structure because B-Spline conform an arbitrary shape by control point set and that it doesn't use any camera parameter. Using a robust algorithm called CHVEP, we find the vanishing point, width of lane and mid-line of lane because of the perspective parallel line and then we can detect the both side of lane mark using B-snake. To demonstrate that this algorithm is robust against noise, shadow and illumination variations in road image, we tested this algorithm about various image divided by weather-fine, rainy and cloudy day. The percentage of correct lane detection is over 95.