gebhart/patrepeval huggingface dataset:
Histological, cellular and behavioral assessments of stroke outcomes after photothrombosis-induced ischemia in adult mice (2014)

Our study demonstrated that first a few days is a critical period that causes brain expansion, cellular proliferation and behavioral deficits in photothrombosis-induced ischemic model, and proliferating astrocytes only have a small contribution to the pools of proliferating cells and reactive astrocytes.
RTL DFT techniques to enhance defect coverage for functional test sequences (2009)

Functional test sequences are often used in manufacturing testing to target defects that are not detected by structural test. However, they suffer from low defect coverage since they are mostly derived in practice from existing design-verification test sequences. Therefore, there is a need to increase their effectiveness using design-for-testablity (DFT) techniques. We present a DFT method that uses the register-transfer level (RTL) output deviations metric to select observation points for an RTL design and a given functional test sequences. Simulation results for six ITC'99 circuits show that the proposed method outperforms two baseline methods for two gate-level coverage metrics, namely bridging and gate-equivalent fault coverage. Moreover, by inserting a small subset of all possible observation points using the proposed method, significant fault coverage increase is obtained for all benchmark circuits.
Virtual Machine Introspection (2014)

Due to exposure to the Internet, virtual machines (VMs) as forms of delivering virtualized infrastructures and resources represent a first point-of-target for security attackers who want to gain access into the virtualization environment. In-VM monitoring approach can be compromised in the event of a successful VM compromise. Virtual Machine Introspection (VMI) takes a different approach of monitoring the guest VMs externally. This paper presents a review on VMI focusing on the typical usages of integrating VMI with other virtualization security techniques.
New integrated full-range MEMS speaker for in-ear applications (2018)

This paper reports the concept, fabrication and characterization of a new kind of MEMS loudspeaker for in-ear applications. The piezoelectrically driven device is designed to operate without a closed membrane, which significantly improves the acoustic performance, efficiency, manufacturability and miniaturization capability. Measurements performed on prototypes mounted to an artificial ear simulator have revealed high sound pressure levels (SPL) of about 110 dB. In contrast to standard state-of-the-art in-ear speakers the SPL can be maintained up to 20 kHz leading to an extraordinarily flat frequency response using electronic equalization. Furthermore, low total harmonic distortion (THD) of less than 2 % and good energy efficiency of more than 105 dB/mW have been observed over almost the entire audio range.
Digitally programmable microfluidic automaton for multiscale combinatorial mixing and sample processing (2012)

A digitally programmable microfluidic Automaton consisting of a 2-dimensional array of pneumatically actuated microvalves is programmed to perform new multiscale mixing and sample processing operations. Large (μL-scale) volume processing operations are enabled by precise metering of multiple reagents within individual nL-scale valves followed by serial repetitive transfer to programmed locations in the array. A novel process exploiting new combining valve concepts is developed for continuous rapid and complete mixing of reagents in less than 800 ms. Mixing, transfer, storage, and rinsing operations are implemented combinatorially to achieve complex assay automation protocols. The practical utility of this technology is demonstrated by performing automated serial dilution for quantitative analysis as well as the first demonstration of on-chip fluorescent derivatization of biomarker targets (carboxylic acids) for microchip capillary electrophoresis on the Mars Organic Analyzer. A language is developed to describe how unit operations are combined to form a microfluidic program. Finally, this technology is used to develop a novel microfluidic 6-sample processor for combinatorial mixing of large sets (>2(6) unique combinations) of reagents. The digitally programmable microfluidic Automaton is a versatile programmable sample processor for a wide range of process volumes, for multiple samples, and for different types of analyses.
NMDA 2A receptors in parvalbumin cells mediate sex-specific rapid ketamine response on cortical activity (2019)

Ketamine has emerged as a widespread treatment for a variety of psychiatric disorders when used at sub-anesthetic doses, but the neural mechanisms underlying its acute action remain unclear. Here, we identified NMDA receptors containing the 2A subunit (GluN2A) on parvalbumin (PV)-expressing inhibitory interneurons as a pivotal target of low-dose ketamine. Genetically deleting GluN2A receptors globally or selectively from PV interneurons abolished the rapid enhancement of visual cortical responses and gamma-band oscillations by ketamine. Moreover, during the follicular phase of the estrous cycle in female mice, the ketamine response was transiently attenuated along with a concomitant decrease of grin2A mRNA expression within PV interneurons. Thus, GluN2A receptors on PV interneurons mediate the immediate actions of low-dose ketamine treatment, and fluctuations in receptor expression across the estrous cycle may underlie sex-differences in drug efficacy.
A voyage of discovery (2015)

Metro-Dora Clifford B.Sc., MBA, AFABth, MELA, outlines her beginnings as a newcomer to Australia 35 years ago, and how her passion for skin health became a reality.
Spectrum analysis using optical processing (1981)

Spectrum analysis is one of the most fundamental tools in science today. Its use in one form or another spans virtually every discipline. It was one of the first recognized applications of optical processing, and the usefulness of optical spectrum analysis has grown remarkably in the past decade. This is due to the fundamental simplicity, parallelism and intrinsic speed of optical spectrum analyzers, the maturity of the components now available, and the remarkable variety and versatility of the processing architectures that have been developed. This paper presents six selected topics on spectrum analysis using optics. The topics were selected because they represent practical techniques with broad applicability and illustrate different aspects of the technology. The topics are grouped by architecture as space integrating and time integrating. The space integrating sections cover radiometry for detecting low-level signals in wide-band noise, programmable filtering of electrical signals for interference rejection applications, and an optical technique that is equivalent to 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sup> -10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sup> parallel filters for application where fast response, high resolution, and wide bandwidth of coverage are simultaneously required. The time integrating sections cover the versatile time integrating spectrum analyzer, and its extension to the calculation of ambiguity surfaces which have important application to radar processing problems requiring simultaneous measurement of a radar return's time of arrival and possible Doppler frequency shift. This process also illustrates the parallel nature of optical operations, and introduces a fundamental concept, the use of one-dimensional optical components configured for performing two-dimensional operations. The discussion of this concept continues into two-dimensional time integrating spectrum analyzers that use two time integrating spectrum analyzers, each capable of resolving N elements, and combines them to produce N <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> resolvable elements in real time.
Virus-like Particles in a Fire Ant, Solenopsis sp., (Hymenoptera: Formicidae) from Brazil (1977)

S. W. Avery, D. P. Jouvenaz, W. A. Banks, D. W. Anthony, Virus-like Particles in a Fire Ant, Solenopsis sp., (Hymenoptera: Formicidae) from Brazil, The Florida Entomologist, Vol. 60, No. 1 (Mar., 1977), pp. 17-20
A Lumped Michelson Interferometric Modulator in Silicon (2014)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text D. Patel, V. Veerasubramanian, S. Ghosh, A. Samani, Q. Zhong, and D. V. Plant, "A Lumped Michelson Interferometric Modulator in Silicon," in CLEO: 2014, OSA Technical Digest (online) (Optica Publishing Group, 2014), paper SM2G.5. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
A Therapeutic Chemical Chaperone Inhibits Cholera Intoxication and Unfolding/Translocation of the Cholera Toxin A1 Subunit (2011)

Cholera toxin (CT) travels as an intact AB(5) protein toxin from the cell surface to the endoplasmic reticulum (ER) of an intoxicated cell. In the ER, the catalytic A1 subunit dissociates from the rest of the toxin. Translocation of CTA1 from the ER to the cytosol is then facilitated by the quality control mechanism of ER-associated degradation (ERAD). Thermal instability in the isolated CTA1 subunit generates an unfolded toxin conformation that acts as the trigger for ERAD-mediated translocation to the cytosol. In this work, we show by circular dichroism and fluorescence spectroscopy that exposure to 4-phenylbutyric acid (PBA) inhibited the thermal unfolding of CTA1. This, in turn, blocked the ER-to-cytosol export of CTA1 and productive intoxication of either cultured cells or rat ileal loops. In cell culture studies PBA did not affect CT trafficking to the ER, CTA1 dissociation from the holotoxin, or functioning of the ERAD system. PBA is currently used as a therapeutic agent to treat urea cycle disorders. Our data suggest PBA could also be used in a new application to prevent or possibly treat cholera.
The Crystal Structures of SrAlF5 and Ba0.43(1)Sr0.57(1)AlF5 (1998)

Two members belonging to the pseudobinary phase diagram of Ba/SrF2 and AlF3 were synthesized. Single domain crystals of SrAlF5 and Ba0.43(1)Sr0.57(1)AlF5 were prepared from the corresponding metal fluorides. The mixed compound Ba0.43(1)Sr0.57(1)AlF5 has been synthesized and characterized in detail for the first time. The structure of SrAlF5 was reinvestigated; a superstructure was found which is absent in Ba0.43(1)Sr0.57(1)AlF5. The compounds crystallize at room temperature in the centrosymmetric tetragonal space groups I41/a and I4/m. Lattice parameters are a = b= 1988.22(14), c = 1432.24(19) and a = b = 1431.32(14), c = 722.83(7) pm. Both structures differ mainly in the AlF6 arrangement situated in the cavities of the matrix structure. In SrAlF5, ordered dimer [Al2F10]4– units are found, whereas in the Ba2+ mixed sample a linear chain of AlF6 octahedra is observed. For both compounds no partial occupation was observed. Sm2+ doped samples are further characterized by luminescence measurements. Four independent sites of alkaline earth atoms were found in the Sm2+ luminescence of the host SrAlF5. Die Kristallstrukturen von SrAlF5 and Ba0.43(1)Sr0.57(1)AlF5 Zwei Verbindungen des pseudobinären Phasendiagramms Ba/SrF2 and AlF3 wurden synthetisiert. Eindomänenkristalle von SrAlF5 und Ba0.43(1)Sr0.57(1)AlF5 wurden aus den entsprechenden Metallfluoriden hergestellt. Die gemischte Verbindung Ba0.43(1)Sr0.57(1)AlF5 wurde synthetisiert und zum ersten Mal detailliert charakterisiert. Die Struktur von SrAlF5 wurde neu bestimmt; eine Überstruktur wurde gefunden, welche bei der Verbindung Ba0.43(1)Sr0.57(1)AlF5 nicht auftritt. Die Verbindungen kristallisieren bei Raumtemperatur in den zentrosymmetrischen Raumgruppen I41/a bzw. I4/m. Gitterkonstanten sind a = b = 1988.22(14), c = 1432.24(19) bzw. a = b=1431.32(14), c = 722.83(7) pm. Beide Strukturen unterscheiden sich hauptsächlich in der Anordnung der AlF6 Oktaeder, welche sich in den Hohlräumen der Hauptstruktur befinden. In SrAlF5 befinden sich geordnete dimere [Al2F10]4–-Einheiten, während in der mit Barium substituierten Verbindung Ketten von AlF6 Oktaedern beobachtet wurden. Bei beiden Verbindungen wurden keine partiellen Besetzungen beobachtet. Sm2+ dotierte Verbindungen wurden durch Lumineszenzmessungen zusätzlich charakterisiert. Das Lumineszenzspektrum von Sm2+ ergab vier unabhängige Atomlagen im Wirtsgitter von SrAlF5.
Self‐service in libraries: an overview (1997)

An overview article about self‐service ought to start with a definition of the concept. Although many of us have some idea of what constitutes self‐service, it is difficult to find a good definition. None of the encyclopaedias I examined had a separate entry for self‐service. The concept appears though in articles about retailing and self‐service restaurants. In the tenth edition of the Merriam‐Webster's Collegiate Dictionary the following definition was given: “the serving of oneself (as in a restaurant or service station) with goods or services to be paid for at a cashier's desk or by means of a coin‐operated mechanism”. This definition is old‐fashioned and much too limited. It does not cover all the aspects of self‐service that have been made possible through technical development. At the end of this article I will come back to a definition more applicable to self‐service for libraries, but I would like to start with an overview of different aspects important to a self‐service library.
Oxymetallation of khellin. Solvomercuration, osmylation, and palladium-catalyzed oxidation of the furan ring in khellin. The synthesis of highly oxygenated chromones and 2-substituted furochromones (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOxymetallation of khellin. Solvomercuration, osmylation, and palladium-catalyzed oxidation of the furan ring in khellin. The synthesis of highly oxygenated chromones and 2-substituted furochromonesRonald B. Gammill and Sharon A. NashCite this: J. Org. Chem. 1986, 51, 16, 3116–3123Publication Date (Print):August 1, 1986Publication History Published online1 May 2002Published inissue 1 August 1986https://pubs.acs.org/doi/10.1021/jo00366a007https://doi.org/10.1021/jo00366a007research-articleACS PublicationsRequest reuse permissionsArticle Views401Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
GROUPWARE TOOLKITS FOR SYNCHRONOUS WORK (1996)

Groupware toolkits let developers build applications for synchronous and distributed computer-based conferencing. This chapter describes four components that we believe toolkits must provide. A run-time architecture automatically manages the creation, interconnection, and communications of both centralized and distributed processes that comprise conference sessions. A set of groupware programming abstractions allows developers to control the behaviour of distributed processes, to take action on state changes, and to share relevant data. Groupware widgets let interface features of value to conference participants be added easily to groupware applications. Session managers let people create and manage their meetings and are built by developers to accommodate the group's working style. We illustrate the many ways these components can be designed by drawing on our own experiences with GroupKit, and by reviewing approaches taken by other toolkit developers.
Generalizing without encoding specifics: Infants infer phonotactic patterns on sound classes (2012)

publication expected April 2012
<i>More than blood</i>, a Novel Gene Required for Mammalian Postimplantation Development (2004)

More than blood (Mtb) is a novel gene that is widely expressed in mouse embryos prior to gastrulation but is subsequently restricted to specific tissues, including the developing central nervous system and hematopoietic organs. Since MTB is highly expressed in the fetal liver and developing thymus, we predicted that MTB would be required for hematopoiesis and that embryos deficient in MTB would die of anemia. Surprisingly, embryos with a targeted disruption of Mtb died prior to the initiation of blood cell development, immediately following implantation. This lethality is due to a defect in expansion of the inner cell mass (ICM), as Mtb(-/-) blastocysts failed to exhibit outgrowth of the ICM, both in vitro and in vivo. Furthermore, Mtb(-/-) blastocysts exhibited a higher frequency of apoptotic cells than wild-type or heterozygous blastocysts. These findings demonstrate that Mtb is a novel gene that is essential for early embryonic development.
Mood and memory. (1981)

This article describes experiments in which happy or sad moods were induced in subjects by hyp- notic suggestion to investigate the influence of emo- tions on memory and thinking. One result was that subjects exhibited mood-state-dependent memory in recall of word lists, personal experiences recorded in a daily diary, and childhood experiences; people recalled a greater percentage of those experiences that were affectively congruent with the mood they were in dur- ing recall. Second, emotion powerfully influenced such cognitive processes as free associations, imaginative fantasies, social perceptions, and snap judgments about others' personalities (e.g., angry subjects generated an- gry associates, told hostile stories, and were prone to find fault with others). Third, when the feeling-tone of a narrative agreed with the reader's emotion, the salience and memorability of events in that narrative were increased. Thus, sad readers attended more to sad material, identified with a sad character from a story, and recalled more about that character. An associative network theory is proposed to account for these several results. In this theory, an emotion serves as a memory unit that can enter into associations with coincident events. Activation of this emotion unit aids retrieval of events associated with it; it also primes emotional themata for use in free association, fantasies, and per- ceptual categorization.
A Groat's Worth More on Moore's Assertion (1965)

A groat's worth more on Moore's assertion John O. Nelson John O. Nelson University of Colorado Search for other works by this author on: Oxford Academic Google Scholar Analysis, Volume 26, Issue 1, October 1965, Page 32, https://doi.org/10.1093/analys/26.1.32 Published: 01 October 1965
GAS PERMEATION THROUGH CHITOSAN MEMBRANES (1983)

Chitosan membranes were prepared by various methods of casting from solution. The permeabilities of CO2 and O2 gases strongly depended on the preparation methods of membranes. Relation between the permeability and the structure of membrane was discussed.
Impact of Surface Polyethylene Glycol (PEG) Density on Biodegradable Nanoparticle Transport in Mucus <i>ex Vivo</i> and Distribution <i>in Vivo</i> (2015)

Achieving sustained drug delivery to mucosal surfaces is a major challenge due to the presence of the protective mucus layer that serves to trap and rapidly remove foreign particulates. Nanoparticles engineered to rapidly penetrate mucosal barriers (mucus-penetrating particles, "MPP") have shown promise for improving drug distribution, retention and efficacy at mucosal surfaces. MPP are densely coated with polyethylene glycol (PEG), which shields the nanoparticle core from adhesive interactions with mucus. However, the PEG density required to impart the "stealth" properties to nanoparticles in mucus, and thus, uniform distribution in vivo, is still unknown. We prepared biodegradable poly(lactic-co-glycolic acid) (PLGA) nanoparticles with a range of PEG surface densities by blending various ratios of a diblock copolymer of PLGA and 5 kDa poly(ethylene glycol) (PLGA-PEG5k) with PLGA. We then evaluated the impact of PEG surface density, measured using an (1)H NMR method, on mucin binding in vitro, nanoparticle transport in freshly obtained human cervicovaginal mucus (CVM) ex vivo, and nanoparticle distribution in the mouse cervicovaginal tract in vivo. We found that at least 5% PEG was required to effectively shield the nanoparticle core from interacting with mucus components in vitro and ex vivo, thus leading to enhanced nanoparticle distribution throughout the mouse vagina in vivo. We then demonstrated that biodegradable MPP could be formulated from blends of PLGA and PLGA-PEG polymers of various molecular weights, and that these MPP provide tunable drug loading and drug release rates and durations. Overall, we describe a methodology for rationally designing biodegradable, drug-loaded MPP for more uniform delivery to the vagina.
Example-Based Image Manipulation (2012)

Many color-related image adjustments can be conveniently executed by exposing at most a small number of parameters to the user. Examples are tone reproduction, contrast enhancements, gamma correction and white balancing. Others require manual touch-ups, applied by means of brush strokes. More recently, a new class of algorithms has emerged, which transfers specific image attributes from one or more example images to a target. These attributes do not have to be well-defined and concepts that are difficult to quantify with a small set of parameters, such as the “mood” of an image, can be instilled upon a target image simply through the mechanism of selecting appropriate examples. This makes example-based image manipulation a particularly suitable paradigm in creative applications, but also finds uses in more technical tasks such as stereo pair correction, video compression, image colorization, panorama stitching and creating night-time images out of day-light shots.
Use of Grout‐Filled Sausages in Coastal Structures (1986)

An alternative to rubble mound construction, with or without precast concrete armor units, is recommended which comprises flexible membranes filled with cement mortar in situ. The placement of these for greatest stability is suggested by maximizing surface contact of sausage type units. Results of tests to derive an economical mortar mix are described. Construction details are outlined together with comparative costs for a marina breakwater.
The Strategic Value of Information: A Manager's Guide to Profiting from Information Systems (2006)

The unprecedented volume of data captured by modern hospitality firms can be used to create economic value. This report provides a methodology to help hospitality managers identify and prioritize possible data-driven initiatives. This process starts with identifying the transaction-processing systems in the organization and inventorying the data they capture and store. After envisioning possible initiatives that employ these data, the methodology suggests a way to prioritize projects to ensure that only those offering positive returns are implemented. The methodology presented here allows managers to make such a cost-benefit assessment for any data-driven initiative.