gebhart/patrepeval huggingface dataset:
Metagenomic Assay for Identification of Microbial Pathogens in Tumor Tissues (2014)

This work describes the design and testing of a PathoChip array containing probes with the ability to detect all known publicly available virus sequences as well as hundreds of pathogenic bacteria, fungi, parasites, and helminths. PathoChip provides wide coverage of microbial pathogens in an economical format. PathoChip screening of DNA plus RNA from formalin-fixed, paraffin-embedded tumor tissues demonstrated the utility of this platform, and the detection of oncogenic viruses was validated using independent PCR and sequencing methods. These studies demonstrate that the PathoChip technology is a valuable strategy for detecting the presence of pathogens in human cancers and other diseases.
GaAs/Al <sub> <i>x</i> </sub> Ga <sub> 1 − <i>x</i> </sub> As quantum well infra-red photodetectors with cutoff wavelength λ <sub>c</sub> = 14.9 μm (1991)

The longest wavelength quantum well infra-red photo-detector (QWIP) ever measured with a cutoff wavelength of λc = 14.9 μm is demonstrated. Prospects for even longer wavelength detectors are promising.
Is There a Better Source of Huperzine A than <i>Huperzia serrata</i>? Huperzine A Content of Huperziaceae Species in China (2005)

A precise and selective reversed phase high-performance liquid chromatographic method was developed for quantifying huperzine A (HupA) in samples of the Huperziaceae in China. This method was used to quantify the levels of HupA in samples of Huperzia serrata collected from a single population at different times of the year, in different organs of the same H. serrata plant, and from different geographical locations of H. serrata plants in China. For different species of Huperziaceae, the highest content of HupA was found in Phlegmariurus carinatus. Members of the genus Phlegmariurus possessed higher levels of HupA than Huperzia species. H. serrata plants growing in humid forests contained significantly more HupA than plants growing in less humid environments. Finally, HupA content varied significantly by season, with the highest levels being found in mid fall and the lowest levels in early spring, suggesting that HupA is turned over in the plant.
Low-Noise THz-Wave Generation from a Dual-Wavelength Fiber Brillouin Cavity Coupled to a UTC-Photodiode (2019)

A dual-wavelength photonic system for carrier-frequency-stable THz signal generation is demonstrated. An in-loop fractional frequency instability $ via synchronization to an external reference while preserving the intrinsic low phase noise of a Brillouin cavity is experimentally demonstrated. © 2019 The Author(s)
Single Event Effects in High Density CMOS SRAMs (1986)

The effects of epi-substrate and a cell power supply layout on heavy-ion induced latch-up for 64K SRAMs are examined by heavy-ion exposure tests using a cyclotron. It is shown that epi-substrate alone is not sufficient to prevent latch-up. A cell power supply layout technique, that is, power is supplied through the well for MOSFETs in the well, combined with epi-substrate is very effective in preventing latch-up for high density CMOS/BULK memories. Soft error cross sections and threshold LETs for various CMOS SRAMs are determined by heavy-ion exposure tests. The threshold LET for conventional 64K SRAMs decreases to about one-fifth that of 1K SRAMs.
Extraocular Circadian Phototransduction in Humans (1998)

Physiological and behavioral rhythms are governed by an endogenous circadian clock. The response of the human circadian clock to extraocular light exposure was monitored by measurement of body temperature and melatonin concentrations throughout the circadian cycle before and after light pulses presented to the popliteal region (behind the knee). A systematic relation was found between the timing of the light pulse and the magnitude and direction of phase shifts, resulting in the generation of a phase response curve. These findings challenge the belief that mammals are incapable of extraretinal circadian phototransduction and have implications for the development of more effective treatments for sleep and circadian rhythm disorders.
Reconstitution of self-organizing protein gradients as spatial cues in cell-free systems (2014)

Intracellular protein gradients are significant determinants of spatial organization. However, little is known about how protein patterns are established, and how their positional information directs downstream processes. We have accomplished the reconstitution of a protein concentration gradient that directs the assembly of the cell division machinery in E.coli from the bottom-up. Reconstituting self-organized oscillations of MinCDE proteins in membrane-clad soft-polymer compartments, we demonstrate that distinct time-averaged protein concentration gradients are established. Our minimal system allows to study complex organizational principles, such as spatial control of division site placement by intracellular protein gradients, under simplified conditions. In particular, we demonstrate that FtsZ, which marks the cell division site in many bacteria, can be targeted to the middle of a cell-like compartment. Moreover, we show that compartment geometry plays a major role in Min gradient establishment, and provide evidence for a geometry-mediated mechanism to partition Min proteins during bacterial development.
Immunomodulatory Effects of Bone Marrow-Derived Mesenchymal Stem Cells on Pro-Inflammatory Cytokine-Stimulated Human Corneal Epithelial Cells (2014)

MSC reduced the expression of adhesion and immunoregulatory molecules on pro-inflammatory cytokine-stimulated HCE-T via the NF-κB transcription pathway. MSC attenuated expression of IDO through both NF-κB transcription and TGF-β1 signaling pathways. Co-culture of HCEC with MSC therefore provides a useful in vitro model to study the anti-inflammatory properties of MSC on corneal epithelium.
Generation and Characterization of a Spike Glycoprotein Domain A-Specific Neutralizing Single-Chain Variable Fragment against Porcine Epidemic Diarrhea Virus (2021)

The emergence of the genotype (G) 2 and re-emergence of the G1 porcine epidemic diarrhea virus (PEDV) has caused severe economic impacts in the past decade. Developments of efficient vaccines against new variants of PEDV have been challenging, not least because of the difficulties in eliciting mucosal and lactogenic immunity. A single-chain fragment variable (scFv) capable of efficient antigen recognition is an alternative to vaccination and treatment of a viral infection. In the present study, the variable regions of the light chain and the heavy chain of a G2b PEDV spike domain A (S1<sup>A</sup>)-specific neutralizing monoclonal antibody (mAb) were sequenced, constructed with a (G4S) x3 linker, and produced by a mammalian protein expression system. Our results demonstrated that the PEDV S1<sup>A</sup> domain scFv was able to bind to S proteins of both G1 and G2b PEDVs. Nevertheless, the scFv was only capable of neutralizing the homologous G2b PEDV but not the G1 PEDV. The binding ability of the G2b-specific neutralizing scFv was not able to predict the neutralizing ability toward heterologous PEDV. The anti-PEDV S1<sup>A</sup> scFv presented herein serves as a potential therapeutic candidate against the virulent G2b PEDV.
Neural Systems Controlling the Drive to Eat: Mind Versus Metabolism (2008)

With the bleak outlook that 75% of Americans will be overweight or obese in 10 years, it is essential to find efficient help very soon. Knowledge of the powerful and complex neural systems conferring the basic drive to eat is a prerequisite for designing efficient therapies. Recent studies suggest that the cross talk between brain areas involved in cognitive, emotional, and metabolic-regulatory functions may explain why energy homeostasis breaks down for many predisposed individuals in our modern environment.
BAM! The Behance Artistic Media Dataset for Recognition Beyond Photography (2017)

Computer vision systems are designed to work well within the context of everyday photography. However, artists often render the world around them in ways that do not resemble photographs. Artwork produced by people is not constrained to mimic the physical world, making it more challenging for machines to recognize.,,This work is a step toward teaching machines how to categorize images in ways that are valuable to humans. First, we collect a large-scale dataset of contemporary artwork from Behance, a website containing millions of portfolios from professional and commercial artists. We annotate Behance imagery with rich attribute labels for content, emotions, and artistic media. Furthermore, we carry out baseline experiments to show the value of this dataset for artistic style prediction, for improving the generality of existing object classifiers, and for the study of visual domain adaptation. We believe our Behance Artistic Media dataset will be a good starting point for researchers wishing to study artistic imagery and relevant problems. This dataset can be found at https://bam-dataset.org/.
Context-based FISH localization of genomic rearrangements within chromosome 15q11.2q13 duplicons (2011)

Chromosome 15 abnormalities associated with SDs were precisely delineated at a resolution equivalent to genomic Southern analysis. This context-dependent approach can define the boundaries of chromosome rearrangements for other genomic disorders associated with SDs.
Vaccinia Virus J1R Protein: a Viral Membrane Protein That Is Essential for Virion Morphogenesis (2002)

Vaccinia virus, a member of the poxvirus family, contains a conserved J1R open reading frame that encodes a late protein of 17.8 kDa. The 18-kDa J1R protein is associated mainly with the membrane fraction of intracellular mature virus particles. This study examines the biological function of J1R protein in the vaccinia virus life cycle. A recombinant vaccinia virus was constructed to conditionally express J1R protein in an isopropyl-beta-D-galactopyranoside (IPTG)-inducible manner. When J1R is not expressed during vaccinia virus infection, the virus titer is reduced approximately 100-fold. In contrast, J1R protein is not required for viral gene expression, as indicated by protein pulse-labeling. J1R protein is also not required for DNA processing, as the resolution of the concatemer junctions of replicated viral DNA was detected without IPTG. A deficiency of J1R protein caused a severe delay in the processing of p4a and p4b into mature core proteins 4a and 4b, indicating that J1R protein participates in virion morphogenesis. Infected cells grown in the absence of IPTG contained very few intracellular mature virions in the cytoplasm, and enlarged viroplasm structures accumulated with viral crescents attached at the periphery. Abundant intermediate membrane structures of abnormal shapes were observed, and many immature virions were either empty or partially filled, indicating that J1R protein is important for DNA packaging into immature virions. J1R protein also coimmunoprecipited with A45R protein in infected cells. In summary, these results indicate that vaccinia virus J1R is a membrane protein that is required for virus growth and plaque formation. J1R protein interacts with A45R protein and performs an important role during immature virion formation in cultured cells.
Synthesis of correlated multichannel random processes (1994)

This paper describes a method for synthesizing multichannel autoregressive (AR) random processes. The procedure allows for the variation of temporal and cross-channel correlation subject to specific constraints for correlation functions. The resulting synthesized processes provide a "fit" in a minimum mean squared error (MMSE) sense to the process correlation functions specified in terms of their temporal and cross-channel correlation parameters. Computer simulation results are presented showing the case of a two-channel AR process with various values of temporal and cross-channel correlation. A method is also suggested to synthesize a more general class of Gaussian processes with unconstrained quadrature components.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The Falls Efficacy Scale International (FES-I). A comprehensive longitudinal validation study (2010)

the current study builds on the previously established psychometric properties of the FES-I. Both scales have acceptable structures, good validity and reliability and can be recommended for research and clinical purposes. Future studies should explore the FES-I's responsiveness to change during intervention studies and confirm suggested cut-points in other settings, larger samples and across different cultures.
Scan performance of infinite arrays of microstrip patch elements loaded with varactor diodes (1993)

The analysis and scanning characteristics of an infinite array of rectangular microstrip patches each loaded with a varactor diode is presented. The analysis is based on full-wave moment method theory and uses attachment modes to accurately model the current through the feed and the diode. The effect of the biased varactor diode on the scan performance is presented, and it is shown that the impedance mismatch caused by a scan blindness can be eliminated. Other characteristics are also given such as: the active element gain, the efficiency of each loaded microstrip element, and the level of cross polarization generated by the loading of the patch. The effect of the diode biasing level as well as the position of the diode on each radiating element on these scan characteristics is also considered.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Strepsiptera Do Not Share Hind Wing Venational Synapomorphies with Coleoptera: A Reply to Kukalová-Peck and Lawrence (1995)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
Random fonts for the simulation of handwriting (1995)

SUMMARY We present several methods for creating a random printed handwriting font based upon a small sample from a person’s own hand. The first method uses random interpolation and possibly random extrapolation. The second method is based upon the random selection of points from the minimal spanning tree formed by the sample. In a third method, we look at the controlled
A Beyond 110 GHz GaN Cascode Low-Noise Amplifier with 20.3 dBm Output Power (2018)

In this paper, we report on the first mm-wave GaN-based low-noise amplifier using a cascode configuration. This MMIC has a small-signal gain well above 30 dB and a noise figure in the range of 7.6 dB at 104 GHz. Moreover, the use of gallium nitride technology allows for achieving state-of-the-art saturated output power, up to 20.3 dBm or 1.3 W/mm at 115 GHz. To our knowledge, the measured gain, noise figure, and output power levels are the best among any of the GaN MMICs beyond 110 GHz reported to date.
Reactive Power Generation by DFIG Based Wind Farms with AC Grid Connection (2007)

Reactive power generation by wind farms, which must operate similar to other conventional power plants, is a major concern during both steady state and fault conditions. This paper addresses the reactive power generation of offshore wind parks using doubly-fed induction generators (DFIGs) connected to the main grid with long cables along with reactive power compensating devices. During steady-state operation, reactive power can be generated with minimum power loss of wind energy system while meeting the grid code requirement. This is an optimization problem which, in this paper, is solved using a new adaptive particle swarm optimization (APSO) embedded in the Newton-Raphson load flow program. During grid disturbance, the wind power generators have to provide voltage support by increasing reactive current supply. The paper also discusses control measures which enable DFIG based wind turbines to provide effective voltage support and is demonstrated on a real offshore wind farm, which is currently in planning stage, in Germany.
Learning How to Learn: Powerful Mental Tools to Help You Master Tough Subject (2018)

Barbara Oakley didn’t begin learning remedial high school algebra until age 26. Now she’s a professor of engineering, a New York Times best-selling author, and instructor of the world’s largest massive open online course, with nearly two million registered students. How did this happen? She learned how to learn, and she now teaches others these practical insights. In this fun-filled keynote, you’ll hear true stories of remarkable transformation and discover intriguing insights from science about how you can change and grow, no matter your age or stage of life. Using metaphor and analogy, which primes neural circuits for difficult topics, Oakley explains how to learn effectively, drawing on her extensive experience as both an engineering professor and a linguist, as well as from key research insights from cognitive psychology and neuroscience. Learn about which techniques help and those that do not, how to use the brain’s different learning modes to their best effect, and about methods like recall, “chunking” and the Pomodoro technique’s approach to beating procrastination. You’ll walk away with practical learning tools based on solid research—and you’ll have fun along the way!
The Frontal Lobes and Consciousness of the Self (1941)

Prefrontal lobotomy bleaches the affective component connected with the consciousness of the self. Patients who are afflicted with a distressing consciousness of the self (either as a unit of society or as a collection of organs) and whose preoccupation is fixed and unyielding, will secure from prefrontal lobotomy definite relief even though certain of their ideas and actions may persist for a long time. Reduction of the affective component allows the personality to appear in purer form, divested of certain restraining features, but essentially unchanged in regard to energy and intelligence, the principal change being an alteration in the direction of interests from within, outward. Prefrontal lobotomy is radical treatment, not only figuratively but literally in that it reaches down to the roots of the personality. If the neurosis or psychosis has its roots in an overwhelming consciousness of the self, and if this consciousness is intractable and disabling, then prefrontal lobotomy may bring peace to the warring mind and a new lease on life.
Plant Growth Promotion by Spermidine-Producing <i>Bacillus subtilis</i> OKB105 (2014)

The interaction between plants and plant-growth-promoting rhizobacteria (PGPR) is a complex, reciprocal process. On the one hand, plant compounds such as carbohydrates and amino acids serve as energy sources for PGPR. On the other hand, PGPR promote plant growth by synthesizing plant hormones and increasing mineral availability in the soil. Here, we evaluated the growth-promoting activity of Bacillus subtilis OKB105 and identified genes associated with this activity. The genes yecA (encoding a putative amino acid/polyamine permease) and speB (encoding agmatinase) are involved in the secretion or synthesis of polyamine in B. subtilis OKB105. Disruption of either gene abolished the growth-promoting activity of the bacterium, which was restored when polyamine synthesis was complemented. Moreover, high-performance liquid chromatography analysis of culture filtrates of OKB105 and its derivatives demonstrated that spermidine, a common polyamine, is the pivotal plant-growth-promoting compound. In addition, real-time polymerase chain reaction analysis revealed that treatment with B. subtilis OKB105 induced expansin gene (Nt-EXPA1 and Nt-EXPA2) expression and inhibited the expression of the ethylene biosynthesis gene ACO1. Furthermore, enzyme-linked immunosorbent assay analysis showed that the ethylene content in plant root cells decreased in response to spermidine produced by OKB105. Therefore, during plant interactions, OKB105 may produce and secrete spermidine, which induces expansin production and lowers ethylene levels.
Synthesis of Unsymmetrical 1,4-Diarylbutadiynes by Stille Coupling (1997)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTSynthesis of Unsymmetrical 1,4-Diarylbutadiynes by Stille CouplingAdelheid GodtView Author Information Max-Planck-Institut für Polymerforschung, Ackermannweg 10, 55128 Mainz, GermanyCite this: J. Org. Chem. 1997, 62, 21, 7471–7474Publication Date (Web):October 17, 1997Publication History Received25 March 1997Published online17 October 1997Published inissue 1 October 1997https://pubs.acs.org/doi/10.1021/jo970549phttps://doi.org/10.1021/jo970549pbrief-reportACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views2546Altmetric-Citations49LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Aromatic compounds,Chemical reactions,Dimerization,Hydrocarbons,Molecules Get e-Alerts
Strategies Facilitating Video Visit Implementation by a Medical Group Serving a Diverse Population (2022)

IntroductionVideo visits have created new opportunities to enhance access to care, but limited information exists on strategies medical groups can employ to facilitate video visit use by higher-risk patients. Our objective was to identify generalizable strategies to facilitate successful delivery of video visits by systems serving highly diverse patient populations. MethodsThe authors conducted a qualitative study of physicians and staff members in a large group practice with 4.5 million patients with diverse race and ethnicity and socioeconomic status. Semi-structured interviews were conducted between January 2021 and April 2021, with key informants identified via purposive and snowball sampling. Video-recorded interviews were transcribed and analyzed using thematic analysis to identify major themes and subthemes. ResultsThe 42 key informants included regional and medical center leaders, primary care physicians, service managers, and medical assistants. Participants described clinical leadership in technology and multidisciplinary collaboration as crucial to sustained video care adoption. Strategies to facilitate real-time learning included local innovation, rapid communication channels, and psychological safety. The organization offered broad access to frequently updated data reports to help managers and practitioners understand processes, measure performance, and share best practices. Medical assistants and physicians developed new approaches to empathize, tailor interactions with patients, and overcome psychological and technical barriers to connecting via video. ConclusionsKey strategies for sustained video care adoption included clinical leadership articulating its purpose, multidisciplinary collaboration, local innovation, effective data use, empathy, and personalized care. These findings provide a model for how health care systems can foster robust adoption of technologies to serve diverse populations.