gebhart/patrepeval huggingface dataset:
Exercise training and glucose uptake by skeletal muscle in rats (1983)

Glucose uptake rates at various insulin concentrations were compared in perfused hindlimbs of sedentary and endurance exercise-trained (treadmill-running) rats. Rates of glucose uptake by hindlimb muscles were approximately 50% higher in the trained than in the untrained animals on the day after the trained rats' last training session. However, by the 2nd day after the trained rats' last training session (40-46 h without exercise), there were no significant differences in glucose uptake rates between the trained and the sedentary rats' hindlimb muscles either in the absence of insulin, at physiological insulin levels, or at a maximally effective insulin concentration. A bout of exercise, consisting of swimming to fatigue on the day before study, and muscle contraction induced by electrical stimulation, both resulted in significant increases in glucose uptake by the rats' perfused hindlimbs; the magnitude of these increases were similar in the trained and untrained rats. We conclude that differences in muscle glucose uptake between trained and untrained rats are due to residual effects of the last exercise session and that training does not result in a long-term adaptive increase in sensitivity of muscle to insulin.
Identification of candidate nasopharyngeal carcinoma serum biomarkers by cancer cell secretome and tissue transcriptome analysis: Potential usage of cystatin A for predicting nodal stage and poor prognosis (2010)

Nasopharyngeal carcinoma (NPC) is usually diagnosed at advanced clinical stages, resulting in poor outcomes. To discover serum biomarkers for improved NPC diagnosis and/or management, we simultaneously analyzed the NPC cell secretome and tissue transcriptome to identify candidate genes/proteins that are highly upregulated in NPC tissues and also secreted/released from NPC cells. Among the 30 candidates identified, 11 proteins were chosen for further validation using the serum samples from NPC patients and healthy controls, including cystatin A, cathepsin B, manganese superoxide dismutase and matrix metalloproteinase 2. The results showed that serum levels of all the four proteins were indeed higher in NPC patients versus healthy controls and that the use of a three-marker panel (cystatin A, manganese superoxide dismutase and matrix metalloproteinase 2) can contribute to a better NPC detection than each marker alone. In addition, a higher pretreated serum level of cystatin A was found to be associated with a higher nodal stage and poorer prognosis of NPC patients and cystatin A could modulate the migration and invasion of NPC cells in vitro. Altogether, our results indicate that analysis of both the cancer cell secretome and tissue transcriptome is a feasible strategy for efficient identification of novel NPC serum marker panel.
Grape Maturity and Light Exposure Affect Berry Methoxypyrazine Concentration (1999)

The effects of berry development and light exposure on the concentrations of 2-methoxy-3-isopropyl- and 2-methoxy-3-isobutylpyrazine (isopropylMP and isobutylMP) were examined in grapes. The concentrations of MPs in unripe grapes (at about 30 days after anthesis) of eight cultivars were higher than those in ripened berries, although the concentration was dependent on cultivar. The MPs in unripe Cabernet Sauvignon grapes which had been removed from the cluster and packed in glass vessels increased under fluorescent light. On the other hand, the isopropylMP in grapes sampled at about 50 or 70 days after anthesis, decreased under such light. The MPs in unripe grapes treated with a saturated solution of CaCl<sub>2</sub>, which might inhibit the formation of MPs in the grapes, were stable in the absence of light, but decreased in the presence of light. Results indicate that light exposure has two opposite effects on the concentration of MPs in grapes: <i>(a)</i> promoting the formation of MPs in immature grapes; and <i>(b)</i> photodecomposing the MPs in ripening grapes.
hiflyViews: New Generation Telemetry Visualization (2006)

hiflyViews is the new generation telemetry visualization component of hifly/spl reg/, GMV's complete monitoring and control solution for satellite fleet operations based on ESA's SCOS-2000 technology. As described in this paper, hiflyViews represents a leap forward in satellite telemetry visualization as follows: flexible data access: data can be accessed in live or retrieval; archived data can be fetched starting from a given time or a set of telemetry parameters having certain values, validities or change rate (slope or first derivative); data can be pushed from the server or pulled from the client; data can be sent always or whenever there is a change. Flexible data presentation: data presentation is performed via the concept of layout (alphanumeric, graphical and synoptic layouts are initially available); layouts can be arranged as desired within a telemetry display; displays can be embedded within other displays; rich text (with varying sizes, fonts, formats ...) is supported throughout. Openness: display definitions are XML documents satisfying a formalized XML schema. Access to data is performed through a fully formalized CORBA ICD (interface control document); there is no need of directly accessing the spacecraft or fleet database. COTS free: open Source technology is used throughout. Full portability: runs in Microsoft Windows, Apple Macintosh and UNIX/Linux environments. Advanced HMI: functions such as drag and drop, scaling, zooming, panning and navigation through hyperlinks as well as unprecedented configurability are readily available. Pluggable into SCOS-2000: hiflyViews' ICDs have been incorporated into the TM refurbishment initiative which should be incorporated into SCOS-2000 R5.0. hiflyViews is adequate for all ground segment telemetry visualization needs at all levels.
Lysophosphatidic acid (LPA) receptors are activated differentially by biological fluids: possible role of LPA‐binding proteins in activation of LPA receptors (2002)

Lysophosphatidic acid (LPA) exerts multiple biological functions through G protein-coupled receptors (EDG2/LPA(1), EDG4/LPA(2), and EDG7/LPA(3)) and is present in serum where it is associated with albumin. In this study we examined LPA activity in various biological fluids by measuring the LPA-induced increase in the intracellular concentration of calcium ion in three types of Sf9 insect cells, each expressing one of the LPA receptors. Using this system, we found that EDG2 and EDG4, but not EDG7, were activated strongly by addition of incubated plasma. By contrast, LPA detected in seminal plasma, which contains a low concentration of albumin, selectively activated EDG7. After LPA in these samples was extracted and reconstituted, it activated all three receptors. We also found that serum albumin readily inhibits the activation of EDG7 but not the activation of EDG2 or EDG4. In addition, plasma from Nagase analbuminemic rats but not plasma from control Sprague-Dawley rats was found to strongly activate EDG7, although the plasma of these two types of rats contained equal amounts of LPA and activated both EDG2 and EDG4. The present study shows that serum albumin can negatively regulate EDG7 but not EDG2 or EDG4, and suggests that protein factors are present in seminal plasma and deliver LPA efficiently to EDG7 but not to EDG2 or EDG4.
Al<sub>2</sub>O<sub>3</sub> Nanotubes Fabricated by Wet Etching of ZnO/Al<sub>2</sub>O<sub>3</sub> Core/Shell Nanofibers (2004)

In nanotube‐based electronics, Al 2 O 3 nanotubes will play a very important role. A method is reported that yields nanotubes with controllable, uniform wall thickness. The Figure represents the stage of the synthesis in which ZnO nanowires synthesized on a thick polycrystalline ZnO layer on a Si substrate have been coated with Al 2 O 3 and the ZnO partially etched away. When the etching is complete, Al 2 O 3 nanotubes remain.
EXTENT OF SURGICAL RESECTION IS INDEPENDENTLY ASSOCIATED WITH SURVIVAL IN PATIENTS WITH HEMISPHERIC INFILTRATING LOW-GRADE GLIOMAS (2008)

GTR was associated with a delay in tumor progression and malignant degeneration as well as improved OS independent of age, degree of disability, histological subtype, or revision versus primary resection. GTR should be safely attempted when not limited by eloquent cortex.
Spinning (2006)

Abstract Metal spinning is a term used to describe the forming of metal into seamless, axisymmetric shapes by a combination of rotational motion and force. This article describes two forming techniques, such as manual spinning and power spinning, for forming seamless metal components. The process technology, equipment, and tooling for both manual spinning and power spinning are also discussed.
Diosgenin induces G2/M cell cycle arrest and apoptosis in human hepatocellular carcinoma cells (2014)

Diosgenin is a major compound of Dioscoreaceae plants such as yam, which is used as a drug in Traditional Chinese Medicine, and a common vegetable worldwide. The anticancer effect of diosgenin has been reported in various tumor cells, including leukemia, gastric, colorectal, and breast cancer. However, the activity of diosgenin on hepatocellular carcinoma (HCC) and the underlying mechanism have not been completely investigated. Therefore, we investigated the efficacy and associated mechanisms of diosgenin in HCC cells. Flow cytometric analysis was performed to determine the presence of cell cycle arrest and apopotic cells. Diosgenin significantly inhibited the growth of Bel-7402, SMMC-7721 and HepG2 HCC cells in a concentration-dependent manner. Diosgenin treatment for 24 h induced G2/M cell cycle arrest and apoptosis of hepatoma cells. Diosgenin inhibited Akt phosphorylation and upregulated p21 and p27 expression, but did not alter the expression of p53, suggesting diosgenin-induced upregulation of p21 and p57 is p53-independent in HCC cells. Diosgenin induced HCC cell apoptosis by activating caspase cascades -3, -8 and -9. However, diosgenin did not affect Bcl-2 and Bax levels. In conclusion, results of the present study suggest that diosgenin may be an active anti-HCC agent obtained from natural plants and provide new insights in understanding the mechanisms of diosgenin.
Antibiotics for the eradication of Propionibacterium acnes biofilms in surgical infection (2007)

For P. acnes spinal instrumentation infections, either penicillin or linezolid plus rifampicin might be equally effective. For shunt infections, as penicillin does not give therapeutic cerebrospinal fluid concentrations, rifampicin plus linezolid might be the treatment of choice. Linezolid alone appears not to be as effective as penicillin against P. acnes biofilms.
Primary rhabdoid tumor of the ovary: When large cells become small cells (2015)

•The third case of pure primary malignant rhabdoid tumor of the ovary (MRTO) is described•SMARCA4 and SMARCB1 genetic analysis and immunohistochemistry are necessary for correct diagnosis of MRTO•MRTO and small cell carcinoma of the ovary, hypercalcemic type are essentially the same and should be treated as such.
Nucleic Acids and Their Analogs as Nanomaterials for Biosensor Development (2006)

Nucleic acids are natural biopolymers that store the genetic information of organisms. This makes the detection and characterization of DNA and RNA a relevant task in biotechnology, with applications ranging from medicine to environmental control. During the last decades, a large effort has been focused on the development of biosensors, among them those devoted to the detection of nucleic acids in natural samples and those that include nucleic acids as nanosized capture probes for different biomolecules. DNA microarray technology has been successfully used in biotechnological applications including genotyping and gene expression studies. Nevertheless, the performance of DNA microarrays has a limitation imposed by the need of a previous fluorescent labeling of the target molecule to be analyzed. This encouraged the use of alternative detection methods, such as optical and electrochemical ones, and recently others based on surface characterization techniques. New trends in nanotechnology point towards new tools for manipulating molecules and macromolecules that could be developed as high performance biosensors. This interdisciplinary approach towards the integration of novel biosensors can benefit from the capability of certain polymers to form self-assembled monolayers (SAMs) on different surfaces. Thiol-modified DNA can form SAMs on gold surfaces with reduced efficiency, and the biological activity of the probe is decreased upon adsorption. Therefore, thiolated DNA has a very limited use in biosensor development. These constraints have been successfully by-passed using uncharged, artificial analogs of natural nucleic acids, such as peptide nucleic acids (PNAs), as molecular probes. This contribution reviews the state of the art in the use of nucleic acids and their analogs as biosensor nanomaterials, and summarizes the novel approach towards the development of biosensors based on SAMs of PNAs. Finally, we present the current trends in this promising aspect of nanobiotechnology.
Active filters with zero amplifier sensitivity (1979)

A general characterization of second-order active-RC filters employing one, two, and three operational amplifiers is given. When certain conditions are met, it is shown that the desired poles can be rendered insensitive to first- and second-order changes in the time constants of the operational amplifiers. Several novel circuits possessing this zero pole-sensitivity property, as well as zero <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">\omega_0</tex> and <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Q</tex> sensitivity properties, are presented and discussed. Experimental verification of the results and comparisons to other popular second-order active-RC realizations bear out the significantly superior performance of these filters.
SARM inhibits both TRIF‐ and MyD88‐mediated AP‐1 activation (2010)

SARM (sterile alpha- and armadillo-motif-containing protein), the fifth identified TIR (Toll-interleukin 1 receptor (IL-1R)) domain-containing adaptors in humans, downregulates NF-kappaB and IRF3 (interferon-regulatory factor 3)-mediated TLR3 and TLR4 signaling. SARM was characterized as a negative regulator of the TRIF (TIR-domain-containing adaptor protein inducing IFN-beta)-dependent pathway via its interaction with TRIF. However, the precise mechanism of action of SARM remains unclear. Here, we demonstrate that SARM inhibits MAPK activation in human embryonic kidney 293 cells, and U937 cells. Both the TRIF- and MyD88-mediated, as well as basal MAPK activity, were repressed, indicating that SARM-mediated inhibition may not be exclusively directed at TRIF or MyD88, but that SARM may also directly inhibit MAPK phosphorylation. The MAPK inhibition effect was verified by RNAi, which increased the basal level of AP-1. Furthermore, LPS challenge upregulated SARM at both the mRNA and protein levels. Finally, we provide evidence to show that truncated SARM changes its subcellular localization, suggesting the importance of the N-terminal and sterile alpha motif domains in the autoregulation of SARM activity.
A 4-tap 125-MHz mixed-signal echo canceller for Gigabit Ethernet on copper wire (2002)

A discrete-time analog echo canceller is described that reduces the echo in the front end of Gigabit Ethernet twisted-pair interfaces. Echo cancellation in the analog domain by means of four taps reduces the complexity of the digital echo canceller and crosstalk cancellers by 50 taps. Designed in a 0.4 /spl mu/m CMOS technology, the circuit employs an LMS algorithm to adapt to the cable length and impedance discontinuities, providing an echo suppression of 10 dB. The design operates at 125 MHz while consuming 43 mW from a 3 V supply.
Antibacterial actions of fatty acids and monoglycerides against<i>Helicobacter pylori</i> (2003)

The bactericidal potencies of saturated and unsaturated fatty acids (FAs) and monoglycerides (MGs) against Helicobacter pylori were determined following short incubations with freshly harvested cells over a range of pHs. FAs and their derivatives with an equivalent-carbon number of 12 were the most potent: lauric acid had a minimum bactericidal concentration (MBC) at pH 7.4 of 1 mM, myristoleic and linolenic acid were the most potent unsaturated FAs (MBCs of 0.5 mM, pH 7.4), and monolaurin was the most potent MG (MBC 0.5 mM). Potencies of saturated FAs were increased sharply by lowering pH, and a decrease of only 0.5 pH units can cause a change from non-lethal to lethal conditions. Conversely, the bactericidal action of monolaurin was not pH-dependent. The bactericidal potencies of unsaturated FAs increased with degree of unsaturation. When more than one FA or FA plus MGs were present, their combined action was additive. Urea and endogenous urease did not protect H. pylori from the bactericidal action of FAs. These results suggest that H. pylori present in the stomach contents (but not necessarily within the mucus barrier) should be rapidly killed by the millimolar concentrations of FAs and MGs that are produced by pre-intestinal lipase(s) acting on suitable triglycerides such as milk fat.
Migration Application from Waterfall to Agile Environments for Effectiveness and Efficiency Strategy (2018)

PT XYZ faced a challenge to compete in the telecommunication industry. by migrating from previous Waterfall Approach to Agile Approach, they expected to speed up the completion of their project compared to prior approach. However, the result proved to be different then what they had targeted. The pr
Comparative Analysis of CpG Islands in Four Fish Genomes (2008)

There has been much interest in CpG islands (CGIs), clusters of CpG dinucleotides in GC-rich regions, because they are considered gene markers and involved in gene regulation. To date, there has been no genome-wide analysis of CGIs in the fish genome. We first evaluated the performance of three popular CGI identification algorithms in four fish genomes (tetraodon, stickleback, medaka, and zebrafish). Our results suggest that Takai and Jones' (2002) algorithm is most suitable for comparative analysis of CGIs in the fish genome. Then, we performed a systematic analysis of CGIs in the four fish genomes using Takai and Jones' algorithm, compared to other vertebrate genomes. We found that both the number of CGIs and the CGI density vary greatly among these genomes. Remarkably, each fish genome presents a distinct distribution of CGI density with some genomic factors (e.g., chromosome size and chromosome GC content). These findings are helpful for understanding evolution of fish genomes and the features of fish CGIs.
A Cost-Efficient Container Orchestration Strategy in Kubernetes-Based Cloud Computing Infrastructures with Heterogeneous Resources (2020)

Containers, as a lightweight application virtualization technology, have recently gained immense popularity in mainstream cluster management systems like Google Borg and Kubernetes. Prevalently adopted by these systems for task deployments of diverse workloads such as big data, web services, and IoT, they support agile application deployment, environmental consistency, OS distribution portability, application-centric management, and resource isolation. Although most of these systems are mature with advanced features, their optimization strategies are still tailored to the assumption of a static cluster. Elastic compute resources would enable heterogeneous resource management strategies in response to the dynamic business volume for various types of workloads. Hence, we propose a heterogeneous task allocation strategy for cost-efficient container orchestration through resource utilization optimization and elastic instance pricing with three main features. The first one is to support heterogeneous job configurations to optimize the initial placement of containers into existing resources by task packing. The second one is cluster size adjustment to meet the changing workload through autoscaling algorithms. The third one is a rescheduling mechanism to shut down underutilized VM instances for cost saving and reallocate the relevant jobs without losing task progress. We evaluate our approach in terms of cost and performance on the Australian National Cloud Infrastructure (Nectar). Our experiments demonstrate that the proposed strategy could reduce the overall cost by 23% to 32% for different types of cloud workload patterns when compared to the default Kubernetes framework.
Adaptive Filtering for Color Filter Array Demosaicking (2007)

Most digital still cameras acquire imagery with a color filter array (CFA), sampling only one color value for each pixel and interpolating the other two color values afterwards. The interpolation process is commonly known as demosaicking. In general, a good demosaicking method should preserve the high-frequency information of imagery as much as possible, since such information is essential for image visual quality. We discuss in this paper two key observations for preserving high-frequency information in CFA demosaicking: (1) the high frequencies are similar across three color components, and (2) the high frequencies along the horizontal and vertical axes are essential for image quality. Our frequency analysis of CFA samples indicates that filtering a CFA image can better preserve high frequencies than filtering each color component separately. This motivates us to design an efficient filter for estimating the luminance at green pixels of the CFA image and devise an adaptive filtering approach to estimating the luminance at red and blue pixels. Experimental results on simulated CFA images, as well as raw CFA data, verify that the proposed method outperforms the existing state-of-the-art methods both visually and in terms of peak signal-to-noise ratio, at a notably lower computational cost.
Pyrvinium pamoate changes alternative splicing of the serotonin receptor 2C by influencing its RNA structure (2013)

The serotonin receptor 2C plays a central role in mood and appetite control. It undergoes pre-mRNA editing as well as alternative splicing. The RNA editing suggests that the pre-mRNA forms a stable secondary structure in vivo. To identify substances that promote alternative exons inclusion, we set up a high-throughput screen and identified pyrvinium pamoate as a drug-promoting exon inclusion without editing. Circular dichroism spectroscopy indicates that pyrvinium pamoate binds directly to the pre-mRNA and changes its structure. SHAPE (selective 2'-hydroxyl acylation analysed by primer extension) assays show that part of the regulated 5'-splice site forms intramolecular base pairs that are removed by this structural change, which likely allows splice site recognition and exon inclusion. Genome-wide analyses show that pyrvinium pamoate regulates >300 alternative exons that form secondary structures enriched in A-U base pairs. Our data demonstrate that alternative splicing of structured pre-mRNAs can be regulated by small molecules that directly bind to the RNA, which is reminiscent to an RNA riboswitch.
Direct Synthesis of Alkoxysilanes by Gas-solid Reactions. (1994)

can be synthesized from silicon or silicon oxide.
Intrinsic microcrystalline silicon (μc-Si:H)-a promising new thin film solar cell material (2002)

"Compensated" microcrystalline silicon is obtained by adding 8-20 ppm diborane in the plasma gas phase. p-i-n cells with such i-layers have increased infrared sensitivity when compared to a-Si:H p-i-n cells. The preparation of the world's first "mixed stacked" a-Si:H//spl mu/c-Si:H tandem cell with an initial efficiency of 9.1% is reported. The /spl mu/c-Si:H cells showed no degradation of the cell performance under intense light-soaking. Typical properties of the /spl mu/c-Si:H cell indicate that the electronic transport is dominated by the crystalline phase of the material.