gebhart/patrepeval huggingface dataset:
Cloning and expression of the human myeloid cell nuclear differentiation antigen: Regulation by interferon α (1992)

The human myeloid cell nuclear differentiation antigen (MNDA) is a protein of 406 amino acids that is expressed specifically in granulocytes, monocytes and earlier stage cells of these lineages. Degenerate oligonucleotides that could encode regions of MNDA amino acid sequence were used to amplify the MNDA cDNA sequence using the polymerase chain reaction. The amplified cDNA product was sequenced to confirm that it encoded the MNDA protein. It was then used as a probe to isolate five clones from a human bone marrow lambda gt10 cDNA library. A clone containing a 1,672 base pair cDNA insert was sequenced and found to encode the entire MNDA open reading frame, as well as 5' and 3' untranslated regions. The primary structure of the MNDA contains extensive regions of sequence similarity with the protein products of the interferon-inducible genes: 204 and interferon regulatory factor 2. In addition, a 12-base sequence matching the interferon-stimulated response element consensus sequence [GAAAN(N)GAAA] is located in the 5' untranslated region of the MNDA cDNA. The 1.8 kb MNDA mRNA was detected only in cells that express the antigen and the level of MNDA mRNA was elevated in cells treated with either recombinant or natural interferon alpha. The MNDA mRNA was not induced by interferon alpha in cells that do not exhibit a constitutive level of the MNDA mRNA. The MNDA contains sequence motifs found in gene regulatory proteins. The expression and the primary structure of the MNDA indicates that it plays a role in the granulocyte/monocyte cell-specific response to interferon.
Concentric Evertor Strength Differences and Functional Ankle Instability: A Meta-Analysis (2009)

Data included the means, SDs, and group sample sizes (or other appropriate statistical information) for the FAI and uninjured groups (or ankles). The standard difference in the means (SDM) for each outcome was calculated using the pooled SD. We tested individual and overall SDMs using the Z statistic and comparisons between fast and slow velocities using the Q statistic. Our analysis revealed that ankles with FAI were weaker than stable ankles (SDM = 0.224, Z = 4.0, P < .001, 95% confidence interval = 0.115, 0.333). We found no difference between the fast- and slow-velocity SDMs (SDM(Fast) = 0.189, SDM(Slow) = 0.244, Q = 29.9, df = 24, P = .187). Because of the small SDM, this method of measuring ankle strength in the clinical setting may need to be reevaluated.
Titration with Oxymorphone Extended Release to Achieve Effective Long-Term Pain Relief and Improve Tolerability in Opioid-Naive Patients with Moderate to Severe Pain (2008)

Oxymorphone ER provided effective pain relief from moderate to severe chronic pain in opioid-naive patients. Gradual titration was well tolerated, with a low rate of discontinuations caused by AEs.
Dynamic database dumping (1978)

Several methods are studied for dynamically creating a dump copy of a database while the database is on-line and being updated by user transactions. The methods can be characterized by whether the dump represents the database that existed at the beginning of the dump creation, at the end, or sometime in the middle. The methods are analyzed to understand the performance tradeoffs between alternate methods. The methods vary in the time required to create the dump and the amount of extra storage needed. A key parameter of a given system is shown to be the ratio of the rate at which database entities are copied into the dump to the rate at which database entities are updated. For certain methods to work, the ratio must exceed one. However, by combining two methods into a hybrid scheme, the ratio need only exceed one half.
Atmospheric Pressure Plasma Printing of Nanomaterials for <i>IoT</i> Applications (2020)

An atmospheric pressure plasma based printer is described as an alternative to conventional techniques including inkjet printing. The approach is demonstrated to be capable of printing various nanomaterials, and adjusting the plasma parameters, carrier gas flows and the physical parameters of the inks or nanomaterial suspensions can optimize the print quality. Raman analysis was used to characterize the oxide materials and carbon nanotubes printed using this technique, revealing high quality prints. The printed carbon nanotubes were used in a gas sensor chip and shown to provide good ammonia detection capability.
Two-Stage Tridiagonal Reduction for Dense Symmetric Matrices Using Tile Algorithms on Multicore Architectures (2011)

While successful implementations have already been written for one-sided transformations (e.g., QR, LU and Cholesky factorizations) on multicore architecture, getting high performance for two-sided reductions (e.g., Hessenberg, tridiagonal and bidiagonal reductions) is still an open and difficult research problem due to expensive memory-bound operations occurring during the panel factorization. The processor memory speed gap continues to widen, which has even further exacerbated the problem. This paper focuses on an efficient implementation of the tridiagonal reduction, which is the first algorithmic step toward computing the spectral decomposition of a dense symmetric matrix. The original matrix is translated into a tile layout i.e., a high performance data representation, which substantially enhances data locality. Following a two stage approach, the tile matrix is then transformed into band tridiagonal form using compute intensive kernels. The band form is further reduced to the required tridiagonal form using a left-looking bulge chasing technique to reduce memory traffic and memory contention. A dependence translation layer associated with a dynamic runtime system allows for scheduling and overlapping tasks generated from both stages. The obtained tile tridiagonal reduction significantly outperforms the state-of-the art numerical libraries (10X against multithreaded LAPACK with optimized MKL BLAS and 2.5X against the commercial numerical software Intel MKL) from medium to large matrix sizes.
Characterization of EEG signals using wavelet transform for motor imagination tasks in BCI systems (2013)

Brain Computer Interface (BCI) covers an area of special interest, mainly due to the research being conducted to control external devices via thought commands, generating solutions in both motor disability and speech. These applications require the use of signal processing in real time, to be used in devices that help people with this type of disabilities. This paper presents a methodology for feature extraction of electroencephalographic (EEG) signals in motor imagery task of both left and right hand, using the public database BCI Competition 2003. It has been used the wavelet transform for the signal decomposition in the spectral bands of interest (known as brain rhythms). The brain rhythms characterization was conducted through relative energy, variance and standard deviation of the wavelet coefficients. In addition, we conducted the relevance analysis through the fuzzy entropy algorithm, to find the most important features within the training set. We obtained a classification accuracy of up to 98.44% using K-NN and SVM algorithms. The classification results allow inferring that the methodology is appropriate for the recognition of imagination movements in people with motor disabilities and could generate solutions in applications of BCI systems.
Analysis of competence and of <i>Brachyury</i> autoinduction by use of hormoneinducible <i>Xbra</i> (1997)

Analysis of gene function in Xenopus development frequently involves over-expression experiments, in which RNA encoding the protein of interest is microinjected into the early embryo. By taking advantage of the fate map of Xenopus, it is possible to direct expression of the protein to particular regions of the embryo, but it has not been possible to exert control over the timing of expression; the protein is translated immediately after injection. To overcome this problem in our analysis of the role of Brachyury in Xenopus development, we have, like Kolm and Sive (1995; Dev. Biol. 171, 267-272), explored the use of hormone-inducible constructs. Animal pole regions derived from embryos expressing a fusion protein (Xbra-GR) in which the Xbra open reading frame is fused to the ligand-binding domain of the human glucocorticoid receptor develop as atypical epidermis, presumably because Xbra is sequestered by the heat-shock apparatus of the cell. Addition of dexamethasone, which binds to the glucocorticoid receptor and releases Xbra, causes formation of mesoderm. We have used this approach to investigate the competence of animal pole explants to respond to Xbra-GR, and have found that competence persists until late gastrula stages, even though by this time animal caps have lost the ability to respond to mesoderm-inducing factors such as activin and FGF. In a second series of experiments, we demonstrate that Xbra is capable of inducing its own expression, but that this auto-induction requires intercellular signals and FGF signalling. Finally, we suggest that the use of inducible constructs may assist in the search for target genes of Brachyury.
Invariant-based data model for image databases (2002)

We describe a new invariant-based data model for image databases under our approach for shape-based retrieval. The data model relies on contours description of the image shape, and emphasizes the use of invariants. Efficient indexing is based on geometric invariant features, while semi-local multi-valued invariant signatures are used for ranking the answers. The advantages of the proposed approach are its ability to retrieve images in situations in which part of the shape is missing (i.e., in case of occlusion or sketch queries), its ability to handle images distorted by different viewpoint transformations, and its ability to flexibly answer queries based on logical or shape descriptions (query by example), or on a combination of both. The approach also handles sketch based queries. We implemented our data model in an object oriented database system with a SQL-like user interface. The paper presents experimental results demonstrating the effectiveness of the proposed approach.
GPON system with user controlled port-ID assignment method (2008)

Passive Optical Network (PON) system with characters of low-cost and high-efficiency has become a promising solution for access network in relieving the bandwidth bottleneck problem. PON system can provide high-speed optical subscriber networks with broad bandwidth and long distance transmission. In current telecommunication carriers' PON system, different service has its given priority which is configured by carriers based on common requirements. However, different users have their own requirement and inflexibility of the given default service priority causes users' inconvenience and frustration. In this paper, we propose a novel method of user controlled Port-IDentifier (Port-ID) assignment in a Gigabit-capable PON (GPON) system. This method provides users a more individualized priority determination mechanism for end users through assigning a multi-level Port-ID to different service. Then users can manage their own bandwidth based on their requirements for different service and carriers can provide a flexible service management mechanism.
Protein microarray characterization of the autoantibody response in systemic lupus erythematosus and related diseases (2001)

We discuss the presence of anti-keratin antibodies (AKA) of the IgG class in patients with defined juvenile idiopathic arthritis (JIA). An indirect immunofluorescence test and rat oesophagus substrate was used for the detection and quantification of AKA antibodies in patients sera. Overall 33/60 patients with JIA had sera positive for AKA (55 %, P = 0,0001) ranging from 1:10 to 1:160 dilutions. Following idiopathic arthritis of childhood classification criteria AKA occurred in 2/7 patients with systemic disease (28,6 %), in 13/30 patients with RF negative polyarthritis (43,3 %, P = 0,008) and in 15/18 RF positive polyarthritis (83,3 %, P = 0,000002). AKA were also found in a small cohort of patients with oligoarthritis (1/3) and psoriatic arthritis (2/2). AKA positivity occurred in 3/26 healthy controls at a 1:20 dilution. The presence of AKA was correlated as well as with the severity of the disease. Our study revealed that AKA was present overall in 18/29 patients (62%) with severe JIA and in 12/26 patients (46,2 %) with non-severe disease, however this did not reach statistical significance (P = 0,18). We also observed that AKA remained positive regardless of disease activity. AKA were detectable in 55,6 % patients with active JIA and in 48,6 % patients in the complete or near remission.
Borabenzene Derivatives. 26.<sup>1</sup> Syntheses of 1-Methylboratabenzene Complexes of Titanium, Zirconium, and Hafnium. Structures of TiCl<sub>3</sub>(C<sub>5</sub>H<sub>5</sub>BMe), TiCl<sub>2</sub>Cp(C<sub>5</sub>H<sub>5</sub>BMe), ZrCl<sub>2</sub>(C<sub>5</sub>H<sub>5</sub>BMe)<sub>2</sub>, and ZrCl<sub>2</sub>Cp*(C<sub>5</sub>H<sub>5</sub>BMe) (1997)

The complexes TiCl3(C5H5BMe) (6a), [MCl3(C5H5BMe)]x (6b, M = Zr; 6c, M = Hf), and MCl2(C5H5BMe)2 (7b, M = Zr; 7c, M = Hf) are obtained from the tetrachlorides MCl4 (M = Ti, Zr, Hf) and Li(C5H5BMe) (3), 2-(Me3Si)C5H5BMe (4), or 2-(Me3Sn)C5H5BMe (5) in excellent yields. The complexes MCl2Cp(C5H5BMe) (8a, M = Ti; 8b, M = Zr) and MCl2Cp*(C5H5BMe) (9b, M = Zr; 9c, M = Hf) are made similarly from the corresponding cyclopentadienyl precursors MCl3Cp (M = Ti, Zr) and MCl3Cp* (M = Zr, Hf). The redox potentials are shifted by 0.35−0.41 V to more anodic values than those for the corresponding Cp complexes. Molecule 6a shows a piano-stool-type structure, while 7b, 8a, and 9b possess typical bent sandwich structures.
Homeostatic control of polo-like kinase-1 engenders non-genetic heterogeneity in G2 checkpoint fidelity and timing (2014)

The G2 checkpoint monitors DNA damage, preventing mitotic entry until the damage can be resolved. The mechanisms controlling checkpoint recovery are unclear. Here, we identify non-genetic heterogeneity in the fidelity and timing of damage-induced G2 checkpoint enforcement in individual cells from the same population. Single-cell fluorescence imaging reveals that individual damaged cells experience varying durations of G2 arrest, and recover with varying levels of remaining checkpoint signal or DNA damage. A gating mechanism dependent on polo-like kinase-1 (PLK1) activity underlies this heterogeneity. PLK1 activity continually accumulates from initial levels in G2-arrested cells, at a rate inversely correlated to checkpoint activation, until it reaches a threshold allowing mitotic entry regardless of remaining checkpoint signal or DNA damage. Thus, homeostatic control of PLK1 by the dynamic opposition between checkpoint signalling and pro-mitotic activities heterogeneously enforces the G2 checkpoint in each individual cell, with implications for cancer pathogenesis and therapy.
Modeling and analysis of DC-DC converters under Pulse Skipping Modulation (2008)

The technique to model DC-DC converters governed by pulse skipping modulation (PSM), which is based on energy balance principle, is not accurate enough. In this paper, an attempt has been made to model them accurately using the discrete-time modeling approach. PSM scheme is essential to improve the efficiency of a DC-DC converter during the light load condition, mainly during standby or sleep mode. Here, a DC-DC boost converter has been considered as an example. There are four different ways by which the inductor current and output voltage can evolve from one clock instant to the next for the PSM operation, i.e., four different regions. The discrete maps have been derived for those regions, which are piecewise smooth. The derived maps have been validated with the actual circuit behavior. For a specific range of the input voltage, it is shown that the entire map turns out to be a one-dimensional discontinuous map. The border collision bifurcation of the map is then analyzed. Stable higher periodic behavior is observed with a nonmonotonic variation in periodicity for a smooth parameter variation, but no chaos. The experimental investigation has been carried out and the results have been presented to validate the theoretical predictions.
Introduction to Compressible Fluid Flow (2013)

Introduction to Compressible Fluid Flow, Second Edition offers extensive coverage of the physical phenomena experienced in compressible flow. Updated and revised, the second edition provides a thorough explanation of the assumptions used in the analysis of compressible flows. It develops in students an understanding of what causes compressible flow
Synthesis of (2S,3S)-[3-2H1]-4-methyleneglutamic acid and (2S,3R)-[2,3-2H2]-4-methyleneglutamic acid (2006)

(2S,3S)-[3-(2)H1]-4-Methyleneglutamic acid 1a and (2S,3R)-[2,3-(2)H2]-4-methyleneglutamic acid 1b have been synthesised for use in biosynthetic and metabolic studies.
Neural-network performance assessment in sonar applications (2002)

The authors focus on passive sonar applications which involve analyzing data with unknown signals. A general set of signal events (which are classified by a human aural analysis) are used for network training. The primary objective of the application is to discriminate between target and nontarget event categories. A ground truth (GT) and classical decision theory are used in assessing various neural-network (NN) classifiers operating on the DARPA Phase 1 data set. Changes in classifier operating point are shown to vary results between classifier type. These results show the importance of identifying the objective of the NN application before performance assessment is made.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Generalized local N-ary patterns for texture classification (2013)

Local Binary Pattern (LBP) has been well recognised and widely used in various texture analysis applications of computer vision and image processing. It integrates properties of texture structural and statistical texture analysis. LBP is invariant to monotonic gray-scale variations and has also extensions to rotation invariant texture analysis. In recent years, various improvements have been achieved based on LBP. One of extensive developments was replacing binary representation with ternary representation and proposed Local Ternary Pattern (LTP). This paper further generalises the local pattern representation by formulating it as a generalised weight problem of Bachet de Meziriac and proposes Local N-ary Pattern (LNP). The encouraging performance is achieved based on three benchmark datasets when compared with its predecessors.
A New Mass-Enhanced Ferromagnet: U<sub>2</sub>PtSi<sub>3</sub> (1991)

We have newly found and succeeded in growing a mass-enhanced ferromagnet U 2 PtSi 3 . The electronic specific heat coefficient is 200 mJ/K 2 per mole of U. The magnetization shows no saturation up to 80 kOe for both the a - and c -axes. The magnitude of remanence is much smaller compared with the effective moment in the paramagnetic phase. Experimental results on single-crystalline samples are presented and discussed.
Effects of Magnetic and Non-Magnetic Impurities on Anisotropic Singlet Superconductors (1987)

We examine effects of magnetic and non-magnetic impurities on superconductors with anisotropic Cooper pairs of spin-singlet and calculate the tunneling density of states. When the Cooper pair has no component with s -symmetry, magnetic impurities result in the same pair-breaking effect as non-magnetic ones, which is weaker than the usual time-reversal symmetry breaking. The recently discovered high T c magnetic superconducting oxides, R-Ba-Cu-O with R being rare-earth ions, are discussed in the light of the present theory.
Microphone array response to speaker movements (2002)

Matched filtering and adaptive beamforming are both necessary for efficient speech dereverberation and noise reduction by microphone arrays. This can be achieved by the identification of impulse responses. We show that adaptive microphone arrays are sensitive to the identification errors of the impulse responses, particularly due to speaker movements. We prove that adjusted matched-filtering and permanent tracking of the impulse responses are also necessary. The proposed microphone array responds well to these requirements under realistic conditions.
Is the UN Worth Saving? (1989)

I have not, in the earlier chapters, dealt with criticisms now voiced about the political role of the United Nations, except incidentally. But the UN has faults, like any human institution. Are these faults those one would expect to find in a large and complex multi-purpose intergovernmental organization now in its fifth decade, or are they faults which could have been prevented if only the states of which the UN is composed had been more altruistic or far-sighted?KeywordsSecurity CouncilWeighted VotePermanent MemberPalestine RefugeeSovereign EqualityThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Synthesis and Crystal Structures of Lithium and Potassium Triazenide Complexes (1998)

Reaction of the 1,2,3-triazene Tol−NN−NH−Tol with bases Li(N(SiMe3)2, n-BuLi, KH, K(N(SiMe3)2, and KO-t-Bu results in deprotonation of the triazene to give the lithium and potassium triazenide complexes. Both have been characterized structurally and have a dimeric core. However, the bonding of the triazenide to the metals is very different.
Serotonin &ndash; Kynurenine Hypothesis of Depression: Historical Overview and Recent Developments (2013)

This mini-review focuses on the studies of late Prof. IP Lapin (1903 - 2012) and his research team on the role of methoxyindole and kynurenine (KYN) pathways of tryptophan (TRP) metabolism in the pathogenesis of depression and action mechanisms of antidepressant effect. In the late 60s of the last century Prof. IP Lapin suggested that "intensification of central serotoninergic processes is a determinant of the thymoleptic (mood elevating) component" while "activation of noradrenergic processes is responsible for psychoenergetic and motor-stimulating component of the clinical antidepressant effect". The cause of serotonin deficiency in depression was attributed to the shunt of TRP "metabolism away from serotonin production towards KYN production" due to cortisol-induced activation of liver enzyme, tryptophan 2,3- dioxygenase, the rate-limiting enzyme of TRP - KYN pathway. Prof. Lapin suggested and discovered that KYN and its metabolites affect brain functions, and proposed the role of neurokynurenines in pathogenesis of depression and action mechanisms of antidepressant effect (kynurenine hypothesis). Further research suggested the antidepressant and cognition- enhancing effects of post-serotonin metabolite, N-acetylserotonin (NAS), an agonist to tyrosine kinase B (TrkB) receptor; and link between depression and chronic inflammation-associated disorders (e.g., insulin resistance, hepatitis C virus) via inflammation-induced activation of indoleamine 2,3- dioxygenase, brain located rate-limiting enzyme of TRY - KYN metabolism. NAS and kynurenines might be the targets for prevention and treatment of depression and associated conditions.