gebhart/patrepeval huggingface dataset:
Relationships between Personality and Burn-Out: An Empirical Study with Helping Professions’ Workers (2015)

Stress-related illnesses, such as burnout, had an increase over the last decade, even though not every employee, in the same workplace, shows burnout symptoms, suggesting that individual factors may contribute to this phenomenon. In fact, even though research on burnout generally has tended to explore the organizational factors associated with this condition, which play certainly an important role, however we cannot ignore the relationship between burnout and personality. This study explored the relationship between personality and burn-out in 144 helping professions' workers. Personality was measured by the Big Five Questionnaire; burn-out was measured by the Link Burn-out Questionnaire. Results confirm a relationship between the two constructs, partially supporting previous research that explained burn-out not only by organizational factors, but also by individual dimensions.
Neurotypy: regional individuality in rat brain detected by immunocytochemistry with monoclonal antibodies. (1982)

Hybridomas from spleen cell fusions of six BALB/c mice immunized with hypothalamus were analyzed by immunocytochemistry for antibodies reactive with paraffin sections of fixed rat brain. In a total of 135 antibody producers, 60% were brain specific. Among these, 54% reacted with glial elements, pituitary cells, or basal lamina of intracerebral capillaries, with little variation among individual hybridomas in each of these groups. Forty-six percent of brain-specific antibodies reacted with neuronal structures, localizing on nerve fibers, neurofibrils, or perikarya. Neuron-specific hybridomas could be classified into groups that localized in anatomically defineable overall patterns. Within these patterns individual hybridomas exhibited extensive qualitative localization diversity ("neurotypy"). Conceivably, the genetic message for a common "proantigen" within an overall pattern may be slightly modified during differentiation of a neuron, thus leading to minor variability in antigenic expression. During antibody formation, similar minor changes occur in the differentiation of the genetic message for the antibody variable region. Apparently, minor changes in the antibody combining site among groups of hybridomas is reflected in the detectability of minor neurotypic changes among differentiated neuronal proantigens. If neurotypy proves to be the result of single-base substitutions or of variability in alignment of peptide-coding exons, the Scharrer concept of the fundamental significance of neurosecretion could also become applicable to neuronal specialization.
Light-trapping silicon solar cells-experimental results and analysis (2002)

A method to identify and quantify light trapping in solar cells is presented. Light-trapping effectiveness depends on the internal reflectivity and texturing of device surfaces. The incorporation of light-trapping features can experimentally be seen in spectral response and reflectance measurements, as well as in the overall light-generated current. Due to the large number of variables that affect light-generated current, an analysis that evaluates only the optical properties of the structure is proposed. The effective optical path length of confined light is proposed as a figure of merit of the optical design. This effective optical path length is shown to be a function of wavelength. Analysis of the near-bandgap light is presented as a monochromatic case with appropriate specifications.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Sensor Placement with Multiple Objectives for Structural Health Monitoring (2014)

Structural health monitoring (SHM) refers to the process of implementing a damage detection and characterization strategy for engineering structures. Its objective is to monitor the integrity of structures and detect and pinpoint the locations of possible damages. Although wired network systems still dominate in SHM applications, it is commonly believed that wireless sensor network (WSN) systems will be deployed for SHM in the near future, due to their intrinsic advantages. However, the constraints (e.g., communication, fault tolerance, energy) of WSNs must be considered before their deployment on structures. In this article, we study the methodology of sensor placement optimization for WSN-based SHM. Sensor placement plays a vital role in SHM applications, where sensor nodes are placed on critical locations that are of civil/structural engineering importance. We design a three-phase sensor placement approach, named TPSP, aiming to achieve the following objectives: finding a high-quality placement for a given set of sensors that satisfies the engineering requirements, ensuring communication efficiency and reliability and low placement complexity, and reducing the probability of failures in a WSN. Along with the sensor placement, we enable sensor nodes to develop “connectivity trees” in such a way that maintaining structural health state and network connectivity, for example, in case of a sensor fault, can be done in a distributed manner. The trees are constructed once (unlike dynamic clusters or trees) and do not incur additional communication costs for the WSN. We optimize the performance of TPSP by considering multiple objectives: low communication cost, fault tolerance, and lifetime prolongation. We validate the effectiveness and performance of TPSP through both simulations using real datasets and a proof-of-concept system on a physical structure.
Emission Characteristics of Electrically Small Radiating Sources from Tests Inside a TEM Cell (1981)

An electrically small radiating source of arbitrary nature may be modeled by an equivalent-dipole system consisting of three orthogonal electric dipoles and three orthogonal magnetic dipoles, each excited with arbitrary amplitude and phase. A method of determining the individual dipole moments and the cross-components of such a dipole system, by tests inside a transverse electromagnetic (TEM) cell, is presented along with some experimental results.
Inhibiting Tankyrases Sensitizes KRAS-Mutant Cancer Cells to MEK Inhibitors via FGFR2 Feedback Signaling (2014)

Tankyrases (TNKS) play roles in Wnt signaling, telomere homeostasis, and mitosis, offering attractive targets for anticancer treatment. Using unbiased combination screening in a large panel of cancer cell lines, we have identified a strong synergy between TNKS and MEK inhibitors (MEKi) in KRAS-mutant cancer cells. Our study uncovers a novel function of TNKS in the relief of a feedback loop induced by MEK inhibition on FGFR2 signaling pathway. Moreover, dual inhibition of TNKS and MEK leads to more robust apoptosis and antitumor activity both in vitro and in vivo than effects observed by previously reported MEKi combinations. Altogether, our results show how a novel combination of TNKS and MEK inhibitors can be highly effective in targeting KRAS-mutant cancers by suppressing a newly discovered resistance mechanism.
The relative gastrointestinal toxicity of the nonsteroidal anti-inflammatory drugs (1987)

• To assess the relative rate of upper gastrointestinal (UGI) tract bleeding associated with nonsteroidal anti-inflammatory drugs (NSAIDs), we performed a retrospective cohort study using 1980 billing data from all Medicaid patients in the states of Michigan and Minnesota. The rate of UGI tract bleeding in the 30 days following each drug exposure was examined in the 88 044 patients dispensed only one of seven NSAIDs. The rate of UGI tract bleeding differed significantly among users of these drugs. Stratification and logistic regression were used to adjust for multiple potential confounding factors, without substantive changes in the results. An alcohol-drug interaction was found. Sulindac users had the highest rate of UGI tract bleeding, and it was the only drug statistically different from ibuprofen. When the average daily dose of sulindac received was divided by the maximum recommended daily dose, it was notably higher than those for other drugs. Repeated analyses using data from 1982 confirmed these results. We conclude that there are significant and consistent differences in the incidence of UGI tract bleeding associated with the use of NSAIDs in this population. (<i>Arch Intern Med</i>1987;147:1054-1059)
The neurexin ligands, neuroligins and leucine-rich repeat transmembrane proteins, perform convergent and divergent synaptic functions in vivo (2011)

Synaptic cell adhesion molecules, including the neurexin ligands, neuroligins (NLs) and leucine-rich repeat transmembrane proteins (LRRTMs), are thought to organize synapse assembly and specify synapse function. To test the synaptic role of these molecules in vivo, we performed lentivirally mediated knockdown of NL3, LRRTM1, and LRRTM2 in CA1 pyramidal cells of WT and NL1 KO mice at postnatal day (P)0 (when synapses are forming) and P21 (when synapses are largely mature). P0 knockdown of NL3 in WT or NL1 KO neurons did not affect excitatory synaptic transmission, whereas P0 knockdown of LRRTM1 and LRRTM2 selectively reduced AMPA receptor-mediated synaptic currents. P0 triple knockdown of NL3 and both LRRTMs in NL1 KO mice yielded greater reductions in AMPA and NMDA receptor-mediated currents, suggesting functional redundancy between NLs and LRRTMs during early synapse development. In contrast, P21 knockdown of LRRTMs did not alter excitatory transmission, whereas NL manipulations supported a role for NL1 in maintaining NMDA receptor-mediated transmission. These results show that neurexin ligands in vivo form a dynamic synaptic cell adhesion network, with compensation between NLs and LRRTMs during early synapse development and functional divergence upon synapse maturation.
Fast Algorithms for Signal Processing (2010)

Efficient signal processing algorithms are important for embedded and power-limited applications since, by reducing the number of computations, power consumption can be reduced significantly. Similarly, efficient algorithms are also critical to very large scale applications such as video processing and four-dimensional medical imaging. This self-contained guide, the only one of its kind, enables engineers to find the optimum fast algorithm for a specific application. It presents a broad range of computationally-efficient algorithms, describes their structure and implementation, and compares their relative strengths for given problems. All the necessary background mathematics is included and theorems are rigorously proved, so all the information needed to learn and apply the techniques is provided in one convenient guide. With this practical reference, researchers and practitioners in electrical engineering, applied mathematics, and computer science can reduce power dissipation for low-end applications of signal processing, and extend the reach of high-end applications.
The solubility of acid gases in methanol. Final report Oct 1976-Sep 1978 (1979)

The report describes a thermodynamic model developed to predict phase-equilibrium behavior in a methanol/carbon-dioxide/nitrogen/hydrogen-sulfide system based on parameters determined from binary vapor/liquid equilibrium data available in the literature. Model predictions are compared with actual experimental data. Predicted values show an average deviation from experimental data of 21% for vapor compositions and 10% for total pressures, indicating the possibility of ternary effects not accounted for by the model. (The model is to be used in conjunction with a coal-gasification/gas-cleaning facility constructed at North Carolina State University as part of a study funded by the EPA. The overall objective of the project is to characterize completely the gaseous and condensed phase emissions from typical coal-gasification/gas-cleaning processes and to determine how emissions depend on process parameters. To describe and evaluate operations involved in the removal of acid gas constituents from the crude synthesis gas, information is needed concerning the equilibrium behavior of these constituents with the particular solvent used in the removal unit; hence, the model.)
Cardiac Mast Cell Stabilization and Cardioprotective Effect of Ischemic Preconditioning in Isolated Rat Heart (1998)

This study was designed to investigate the effect of disodium cromoglycate (DSCG), a mast cell stabilizer, on cardioprotective effect of ischemic preconditioning. Isolated rat heart was subjected to 30 min of global ischemia followed by 30 min of reperfusion. Ischemic preconditioning was provided by four episodes of 5-min global ischemia followed by 5 min of reperfusion before sustained ischemia. Ischemic preconditioning and DSCG (10 and 100 microM) treatment markedly decreased the release of lactate dehydrogenase (LDH) and creatine kinase (CK) in coronary effluent and percentage incidence of ventricular premature beats (VPBs) and ventricular tachycardia/fibrillation (VT/VF) during reperfusion. Ischemic preconditioning and DSCG treatment also significantly reduced ischemia/reperfusion-induced mast cell peroxidase (MPO) release, a marker of mast cell degranulation. A significant increase in MPO release was observed immediately after ischemic preconditioning, and the release was found to be inhibited in hearts perfused with DSCG (10 and 100 microM) during ischemic preconditioning. DSCG administered during ischemic preconditioning (DSCG in ischemic preconditioning) attenuated the cardioprotective and antiarrhythmic effects of ischemic preconditioning. DSCG in ischemic preconditioning produced no marked effect on ischemia/reperfusion-induced MPO release. These findings tentatively suggest that DSCG administration during ischemic preconditioning abolishes its cardioprotective effect, perhaps by stabilizing resident cardiac mast cells.
Eine Antilogie des Eutherios von Tyana. Edited by Martin Tetz. (Patristische Texte und Studien, 1). Pp. lxvi + 90. Berlin: Walter de Gruyter, 1964. DM. 36.00. (1965)

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Opioid Receptor Gene (<i>OPRM1</i>, <i>OPRK1</i>, and <i>OPRD1</i>) Variants and Response to Naltrexone Treatment for Alcohol Dependence: Results From the VA Cooperative Study (2007)

These results do not support association of the OPRM1 Asn40Asp polymorphism with NTX treatment response for AD.
Modular Multilevel Converters for Transportation Electrification: Challenges and Opportunities (2018)

The power converters based on a modular structure have gained importance for electric transportation applications, including electric vehicles (EVs), EV charging stations, railway traction, and electric ships. Modular multilevel converters (MMCs) are recognized as one of the promising topologies to improve the energy conversion efficiency and fault-tolerant ability of power conversion systems. This paper aims at a review of latest research contributions regarding the evolution of circuit topologies, operational challenges, control schemes, and fault-tolerant strategies of the MMC. Finally, the current state of the art, opportunities and the future perspective of MMC in electric transportation applications are addressed.
Radar system description (1985)

A brief overview is given of the hardware and software utilized to generate the CV-990 synthetic aperture radar's image products. The on-board hardware is described, then the operational processing software, and finally the image products that are routinely available.
An 1 GHz class E LDMOS power amplifier (2004)

A class E power amplifier working at 1 GHz and with an LDMOS transistor as switching element has been developed. The circuit is implemented with lumped and distributed elements. An output power of 6.2 W at 69% drain efficiency with a gain of 11 dB was obtained at 1 GHz. Both simulations and measurements of the amplifier are presented within this paper. This is to our knowledge the highest efficiency and output power reported for a class E amplifier at 1 GHz.
dsRNA-Dependent Protein Kinase PKR and its Role in Stress, Signaling and HCV Infection (2012)

The double-stranded RNA-dependent protein kinase PKR plays multiple roles in cells, in response to different stress situations. As a member of the interferon (IFN)‑Stimulated Genes, PKR was initially recognized as an actor in the antiviral action of IFN, due to its ability to control translation, through phosphorylation, of the alpha subunit of eukaryotic initiation factor 2 (eIF2a). As such, PKR participates in the generation of stress granules, or autophagy and a number of viruses have designed strategies to inhibit its action. However, PKR deficient mice resist most viral infections, indicating that PKR may play other roles in the cell other than just acting as an antiviral agent. Indeed, PKR regulates several signaling pathways, either as an adapter protein and/or using its kinase activity. Here we review the role of PKR as an eIF2a kinase, its participation in the regulation of the NF-kB, p38MAPK and insulin pathways, and we focus on its role during infection with the hepatitis C virus (HCV). PKR binds the HCV IRES RNA, cooperates with some functions of the HCV core protein and may represent a target for NS5A or E2. Novel data points out for a role of PKR as a pro-HCV agent, both as an adapter protein and as an eIF2a-kinase, and in cooperation with the di-ubiquitin-like protein ISG15. Developing pharmaceutical inhibitors of PKR may help in resolving some viral infections as well as stress-related damages.
Development of a field sequential color view finder for color video cameras (1993)

A miniature high-resolution color display unit has been developed as a view finder for consumer color video cameras. This field sequential color display system produces a color picture without the use of dots. This system is a great improvement over color liquid crystal displays, solving problems such as resolution and color representation. Resolution is dependent upon the time compression circuit's performance. This color display maintains good contrast under a variety of light situations, including those out of doors, because the color filter, which is located in front of the CRT (cathode ray tube) screen, reduces reflection of outer light on the display area.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Microsaccade Characteristics in Neurological and Ophthalmic Disease (2018)

Microsaccade research has recently reached a critical mass of studies that allows, for the first time, a comprehensive review of how microsaccadic dynamics change in neurological and ophthalmic disease. We discuss the various pathological conditions that affect microsaccades, their impact on microsaccadic and other fixational eye movement dynamics, and the incipient studies that point to microsaccadic features as potential indicators of differential and early diagnoses of multiple clinical conditions, from movement disorders to attention-deficit hyperactivity disorder to amblyopia. We propose that the objective assessment of fixational eye movement parameters may help refine differential diagnostics in neurological disease and assist in the evaluation of ongoing therapy regimes. In addition, determining the effects of ophthalmic disease on fixational eye movement features may help evaluate visual impairment in an objective manner, particularly in young patients or those experiencing communication difficulties.
Mesyl phosphoramidate antisense oligonucleotides as an alternative to phosphorothioates with improved biochemical and biological properties (2019)

Here we describe a DNA analog in which the mesyl (methanesulfonyl) phosphoramidate group is substituted for the natural phosphodiester group at each internucleotidic position. The oligomers show significant advantages over the often-used DNA phosphorothioates in RNA-binding affinity, nuclease stability, and specificity of their antisense action, which involves activation of cellular RNase H enzyme for hybridization-directed RNA cleavage. Biological activity of the oligonucleotide analog was demonstrated with respect to pro-oncogenic miR-21. A 22-nt anti-miR-21 mesyl phosphoramidate oligodeoxynucleotide specifically decreased the miR-21 level in melanoma B16 cells, induced apoptosis, reduced proliferation, and impeded migration of tumor cells, showing superiority over isosequential phosphorothioate oligodeoxynucleotide in the specificity of its biological effect. Lower overall toxicity compared with phosphorothioate and more efficient activation of RNase H are the key advantages of mesyl phosphoramidate oligonucleotides, which may represent a promising group of antisense therapeutic agents.
β Chemokines costimulate lymphocyte cytolysis, proliferation, and lymphokine production (1996)

We report here the ability of the beta chemokines MIP-1 alpha, MIP-1 beta, RANTES, and MCP-1 to enhance some lymphocyte effector functions. Initial studies focused on the effects of chemokines on human and mouse cytotoxic T lymphocyte (CTL)- and natural killer (NK) cell-specific cytolytic responses. The results demonstrate that beta chemokines are capable of augmenting mouse and human CTL and human NK- but not lymphokine-activated killer cell- or antibody-dependent cell cytotoxicity-specific cytolytic responses. Neutralization analysis utilizing integrin-specific antibodies revealed that CTL/NK tumor cell conjugate formation is required for chemokine-induced killing. In addition, both CTLs and NK cells incubated with various beta chemokines were induced to degranulate and release granule-derived serine esterases, suggesting that chemokines may be important costimulators of CTL and NK cell degranulation and may thus augment local target cell destruction. Chemokines also modulate antigen-driven T cell proliferative responses as well as effects on lymphokine production. Many of the beta chemokines were found to potentiate human and mouse antigen-specific Th1 and Th2 clone activation promoting cellular proliferation and the release of various lymphokines. This chemokine-mediated T cell proliferation was chemokine and antigen dose dependent as well as clone dependent. Chemokine pretreatment analyses with T cells and antigen-presenting cells (APCs) revealed that chemokines up-regulate both T cells and antigen- presenting cells (APCs) revealed that chemokines up-regulate both T cell and APC functions. Costimulation assays using immobilized antiCD3 monoclonal antibody-coated plates and purified human and mouse T cells and T cell clones in the presence of various chemokines also exhibited enhanced proliferation and lymphokine secretion. This costimulation was interleukin-2 dependent and required the presence of free extracellular calcium. Examination of chemokine-treated APCs revealed that the T cell costimulatory molecule B7-1 was induced by various beta chemokines. Neutralization of endogenously produced chemokines, with specific antibodies during an antigen-specific T cell response blocked cellular proliferation, suggesting that the chemokines have an autocrine role in antigen-induced T cell proliferative responses. Together, these results suggest that chemokines play a significant role in the activation of polyclonal as well as antigen-specific helper and cytotoxic T cells during the genesis of an immune response.