gebhart/patrepeval huggingface dataset:
Hierarchical Key Distribution Scheme for Conditional Access System in DTV Broadcasting (2006)

A variety of subscriptions in Conditional Access System (CAS) of DTV broadcasting network bring complexity to the key distribution scheme. In this paper, an innovation of hierarchical key distribution scheme for CAS in DTV broadcasting is proposed to reduce the computation of encryption and the number of messages for key refreshment. Compared with the conventional key distribution schemes, no encrypted message is distributed for key refreshment when a subscriber leaves. Further more, our hierarchical tree of key can provide a lot more dynamic management, from which broadcasters can improve efficiency in managing program channels.
A model for recognition of polychlorinated dibenzo‐<i>p</i>‐dioxins by the aryl hydrocarbon receptor (2002)

Ligand binding by the aryl hydrocarbon receptor (AhR), a member of the bHLH-PAS family of transcriptional regulatory proteins, has been mapped to a region within the second 'PAS' domain, a conserved sequence motif first discovered in the Per-ARNT-Sim family of proteins. In addition to the bacterial photoactive yellow protein (PYP), which had been proposed as a structural prototype for the three dimensional fold of PAS domains, two crystal structures of the PAS domain have recently been determined: the human potassium channel HERG and the heme binding domain of the bacterial O(2) sensing FixL protein. The three structures reveal a highly conserved structural framework in evolutionary rather distant PAS domains, provide a more general view of how these domains can recognize their ligands and suggest a structure-function relationship that we exploited to build a three-dimensional model of the ligand binding domain (LBD) of the mouse aryl hydrocarbon receptor (mAhR). The model allowed us to putatively identify the residues responsible for the recognition of polychlorinated dibenzo-p-dioxins (PCDDs) by AhR receptors and to formulate an hypothesis on the signal transduction mechanism.
Effects of ambient conditions on the risk of pressure injuries in bedridden patients—multi‐physics modelling of microclimate (2017)

Scientific evidence regarding microclimate and its effects on the risk of pressure ulcers (PU) remains sparse. It is known that elevated skin temperatures and moisture may affect metabolic demand as well as the mechanical behaviour of the tissue. In this study, we incorporated these microclimate factors into a novel, 3-dimensional multi-physics coupled model of the human buttocks, which simultaneously determines the biothermal and biomechanical behaviours of the buttocks in supine lying on different support surfaces. We compared 3 simulated thermally controlled mattresses with 2 reference foam mattresses. A tissue damage score was numerically calculated in a relevant volume of the model, and the cooling effect of each 1°C decrease of tissue temperature was deduced. Damage scores of tissues were substantially lower for the non-foam mattresses compared with the foams. The percentage tissue volume at risk within the volume of interest was found to grow exponentially as the average tissue temperature increased. The resultant average sacral skin temperature was concluded to be a good predictor for an increased risk of PU/injuries. Each 1°C increase contributes approximately 14 times as much to the risk with respect to an increase of 1 mmHg of pressure. These findings highlight the advantages of using thermally controlled support surfaces as well as the need to further assess the potential damage that may be caused by uncontrolled microclimate conditions on inadequate support surfaces in at-risk patients.
Labeling hESCs and hMSCs with Iron Oxide Nanoparticles for Non-Invasive in vivo Tracking with MR Imaging (2008)

In recent years, stem cell research has led to a better understanding of developmental biology, various diseases and its potential impact on regenerative medicine. A non-invasive method to monitor the transplanted stem cells repeatedly in vivo would greatly enhance our ability to understand the mechanisms that control stem cell death and identify trophic factors and signaling pathways that improve stem cell engraftment. MR imaging has been proven to be an effective tool for the in vivo depiction of stem cells with near microscopic anatomical resolution. In order to detect stem cells with MR, the cells have to be labeled with cell specific MR contrast agents. For this purpose, iron oxide nanoparticles, such as superparamagnetic iron oxide particles (SPIO), are applied, because of their high sensitivity for cell detection and their excellent biocompatibility. SPIO particles are composed of an iron oxide core and a dextran, carboxydextran or starch coat, and function by creating local field inhomogeneities, that cause a decreased signal on T2-weighted MR images. This presentation will demonstrate techniques for labeling of stem cells with clinically applicable MR contrast agents for subsequent non-invasive in vivo tracking of the labeled cells with MR imaging.
Stable self-organization of sensory recognition codes: Is chaos necessary? (1987)

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Dose dependency of outcomes of intrapleural fibrinolytic therapy in new rabbit empyema models (2016)

The incidence of empyema (EMP) is increasing worldwide; EMP generally occurs with pleural loculation and impaired drainage is often treated with intrapleural fibrinolytic therapy (IPFT) or surgery. A number of IPFT options are used clinically with empiric dosing and variable outcomes in adults. To evaluate mechanisms governing intrapleural fibrinolysis and disease outcomes, models of Pasteurella multocida and Streptococcus pneumoniae were generated in rabbits and the animals were treated with either human tissue (tPA) plasminogen activator or prourokinase (scuPA). Rabbit EMP was characterized by the development of pleural adhesions detectable by chest ultrasonography and fibrinous coating of the pleura. Similar to human EMP, rabbits with EMP accumulated sizable, 20- to 40-ml fibrinopurulent pleural effusions associated with extensive intrapleural organization, significantly increased pleural thickness, suppression of fibrinolytic and plasminogen-activating activities, and accumulation of high levels of plasminogen activator inhibitor 1, plasminogen, and extracellular DNA. IPFT with tPA (0.145 mg/kg) or scuPA (0.5 mg/kg) was ineffective in rabbit EMP (n = 9 and 3 for P. multocida and S. pneumoniae, respectively); 2 mg/kg tPA or scuPA IPFT (n = 5) effectively cleared S. pneumoniae-induced EMP collections in 24 h with no bleeding observed. Although intrapleural fibrinolytic activity for up to 40 min after IPFT was similar for effective and ineffective doses of fibrinolysin, it was lower for tPA than for scuPA treatments. These results demonstrate similarities between rabbit and human EMP, the importance of pleural fluid PAI-1 activity, and levels of plasminogen in the regulation of intrapleural fibrinolysis and illustrate the dose dependency of IPFT outcomes in EMP.
Changes in brain gene expression shared by scrapie and Alzheimer disease. (1989)

We have isolated two recombinant cDNAs whose corresponding RNAs have an increased abundance in scrapie-infected hamster brain. DNA sequence analysis has shown that these two recombinants represent the genes for sulfated glycoprotein 2 and transferrin. The abundance of sulfated glycoprotein 2 RNA is increased in hippocampus from patients with Alzheimer disease and Pick disease, whereas transferrin RNA is not strongly modulated in these conditions. Expression of two previously identified scrapie-modulated genes, encoding glial fibrillary acidic protein and metallothionein, is also increased in both of these neurodegenerative diseases.
Quantification of blood volume by electrical impedance tomography using a tissue-equivalent phantom (1998)

An in vivo electrical impedance tomography (EIT) system was designed to accurately estimate quantities of intra-peritoneal blood in the abdominal cavity. For this it is essential that the response is relatively independent of the position of the high conductivity anomaly (blood) in the body. The sensitivity of the system to the introduction of blood-equivalent resistivity anomalies was assessed by using a cylindrical tissue-equivalent phantom. It was found that a satisfactorily uniform response of the system in both radial (transverse) and axial (longitudinal) directions in the phantom could be achieved by filtering resistivity profile images obtained by EIT measurement, and by using extended electrodes to collect data. Post-processing of single impedance images gave rise to a quantity denoted the resistivity index. A filter was then used to remove the remaining radial variation of the resistivity index. It was calculated by evaluating the resistivity index of a number of theoretically calculated images, and constructing a correction filter similar to those used to remove lens imperfections, such as coma, in optical components. The 30% increase in the resistivity index observed when an anomaly was moved to the maximum extent allowed by the filter calculation (0.75 of the phantom radius) was reduced by the filter to 6%. A study of the axial dependence observed in the resistivity index using electrodes extended in the axial direction by +/-5 cm found that the variation in resistivity index with axial position was about half of that observed using small circular electrodes similar to those used in the Sheffield mark I system.
Glucose-oxidase Based Self-Destructing Polymeric Vesicles (2004)

We have designed oxidation-responsive vesicles from synthetic amphiphilic block copolymers ("polymersomes") of ethylene glycol and propylene sulfide. Thioethers in the hydrophobic poly(propylene sulfide) block are converted into the more hydrophilic sulfoxides and sulfones upon exposure to an oxidative environment, changing the hydrophilic-lipophilic balance of the macroamphiphile and thus inducing its solubilization. Here we sought to explore generation of the oxidative environment and induction of polymersome destabilization through production of hydrogen peroxide by the glucose-oxidase (GOx)/glucose/oxygen system. We studied the encapsulation of GOx within polymersomes, its stability and activity, and glucose-triggered polymersome destabilization. Stimulus-responsive polymersomes may find applications as nanocontainers in sensing devices and as drug delivery systems.
Modelling of a Solid-Electrolyte Oxygen Sensor (2002)

<div class="htmlview paragraph">The limiting values for NO<sub>x</sub> and HC concentrations in the exhaust gas of SI engines will be further lowered by legislation in many countries during the next years. This necessitates an improvement of the pollution control systems, which is achieved by including the dynamics of the three way catalyst into the control system. Before a control system can be designed, the dynamic behaviour of the exhaust after treatment system including the sensors has to be properly analyzed. As a first step a dynamic model of a solid-electrolyte oxygen sensor has been derived. It was the goal to obtain a better understanding of the cross sensitivities towards both reducing and oxidizing exhaust gas components such as H<sub>2</sub>, CO, O<sub>2</sub> and NO.</div> <div class="htmlview paragraph">The model consists of three parts. Firstly, the porous protection layer, where only diffusion is assumed to occur, secondly the porous catalytic electrodes where the redox reactions take place and thirdly the solid electrolyte, where the electric potential is generated. The catalytic electrodes are mainly modelled with Langmuir-Hinshelwood kinetics, partly extended by structures obtained from earlier investigations of catalytic converters.</div> <div class="htmlview paragraph">The static characteristics including their sensitivities towards the exhaust gas components can be well reproduced within the range of interest, i.e. as expected to occur in the exhaust gas system of an SI engine. It can be shown that the air-to-fuel ratio rather than the actual oxygen fraction in the exhaust gas is responsible for the output voltage. The behaviour of the sensor output is very sensitive to reducing species, especially H<sub>2</sub>.</div>
An Efficient Method for the Cryopreservation of Fetal Human Liver Hematopoeitic Progenitor Cells (2001)

The use of human hematopoietic progenitor cells (HPC) for transplantation requires efficient recovery methods and cryopreservation procedures. The purpose of this study was to determine cryopreservation techniques for fetal human liver (FHL) CD34(+) cells. We assessed FHL HPC recovery efficiency after freezing and thawing by viability testing, fluorescence-activated cell sorting analysis, and colony-forming ability under different conditions. We also determined optimal cell freezing concentrations and the effect of rate-controlled freezing on cell recovery. Lastly, cell recovery after varying freezing time periods was examined. Our results indicated that optimal cell recovery occurs when: A) cryopreservation medium consists of either 5% dimethylsulphoxide (DMSO) or 10% DMSO in combination with either 20% fetal bovine serum (FBS) or 70% FBS and when Iscove's modified Dulbecco's medium consists of not more than 10% DMSO; B) a rate-controlled freezing device container is used; C) CD34(+) cells are frozen at a concentration of 1 x 10(6)/ml, and D) a thawing temperature of 37 degrees C is used. These observations indicate that cryopreservation of FHL HPC is possible for up to 18 months in optimal conditions without losing hematopoietic activity.
Comparative tyrosine-kinase profiles in colorectal cancers: Enhanced arg expression in carcinoma as compared with adenoma and normal mucosa (1999)

There is strong evidence that tyrosine kinases are involved in the regulation of cellular growth and tumor progression. Over-expressions of tyrosine kinases have been documented in a number of neoplasms. To study the roles of tyrosine kinases in colon cancer, we developed a tyrosine-kinase-expression profile for each of the four different stages of colon carcinogenesis, using normal colon mucosa, adenomatous polyps, primary carcinoma and hepatic metastases collected from the same patient. We identified 30 tyrosine kinases expressed in these tissues: they include 10 non-receptor tyrosine kinases (yes, fyn, lyn, brk, abl, arg, jak1, jak3, tyk2 and itk), 17 receptor tyrosine kinases (erbB2, PDGF-Ralpha, PDGF-Rbeta, kit, c-fms, met, ron, FGF-R1, FGF-R2, FGF-R3, FGF-R4, cek5, tie-1, tkt, axl, sky and Ins-R), 2 dual kinases (mek and sek) and one possible novel kinase. Among these kinases, arg kinase appears to be expressed at a higher level in primary carcinoma and metastatic tumor than in adjacent normal mucosa or adenomatous polyp. This result was confirmed by extensive analysis of 50 additional matched sets of normal colon and colon-tumor specimens, using arg-specific primers and RT-PCR reactions. This study identifies a possible role for arg tyrosine kinase in colon carcinogenesis, especially in the transition from adenoma to carcinoma.
HyperMail: treating electronic mail as literature (1990)

The huge flux of electronic information surrounding the modern researcher requires new tools for its management. HyperMail is a simple tool built on the HyperCard environment for use as a retrospective aid, for relatively stable collections of Email messages concerning a relatively focused topic. By allowing users to swiftly locate, examine and compare messages across authors and across time, the original conversation can become a rich source of subsequent study. Our goal is to treat Email as a form of literature , worthy of the same preservation and augmentation that is typical of traditional printed media.
Maximal Flow Through a Network (2009)

The problem discussed in this paper was formulated by T. Harris as follows:“Consider a rail network connecting two cities by way of a number of intermediate cities, where each link of the network has a number assigned to it representing its capacity. Assuming a steady state condition, find a maximal flow from one given city to the other.”
Elastomer-toughened polyimide adhesives (1980)

A study has been conducted to determine the effects of added elastomers on the Tg, thermal stability, adhesive strength, and fracture toughness of LARC-13, a high-temperature addition polyimide adhesive. Various butadiene/acrylonitrile and silicone elastomers were incorporated into the polyimide resin (1) as physical polyblends, and (2) by chemically reacting the elastomers with the polyimide backbone. Adhesive single lap-shear and T-peel strengths were measured before and after aging at elevated temperature. A tapered double-cantilever beam specimen was used to determine the fracture toughness of the elastomer-modified polyimide adhesives.
Algorithm-Based Fault Tolerance for Parallel Stencil Computations (2019)

The increase in HPC systems size and complexity, together with increasing on-chip transistor density, power limitations, and number of components, render modern HPC systems subject to soft errors. Silent data corruptions (SDCs) are typically caused by such soft errors in the form of bit-flips in the memory subsystem and hinder the correctness of scientific applications. This work addresses the problem of protecting a class of iterative computational kernels, called stencils, against SDCs when executing on parallel HPC systems. Existing SDC detection and correction methods are in general either inaccurate, inefficient, or targeting specific application classes that do not include stencils. This work proposes a novel algorithm-based fault tolerance (ABFT) method to protect scientific applications that contain arbitrary stencil computations against SDCs. The ABFT method can be applied both online and offline to accurately detect and correct SDCs in 2D and 3D parallel stencil computations. We present a formal model for the proposed method including theorems and proofs for the computation of the associated check-sums as well as error detection and correction. We experimentally evaluate the use of the proposed ABFT method on a real 3D stencil-based application (HotSpot3D) via a fault-injection, detection, and correction campaign. Results show that the proposed ABFT method achieves less than 8% overhead compared to the performance of the unprotected stencil application. Moreover, it accurately detects and corrects SDCs. While the offline ABFT version corrects errors more accurately, it may incur a small additional overhead than its online counterpart.
Warm Forming High-Strength Aluminum Automotive Parts (1977)

<div class="htmlview paragraph">This paper is concerned with press forming of work hardened or age hardened aluminum alloy sheet at temperatures in the range 100-300°C. By controlling the time and temperature of forming below that necessary for recrystallization or over-aging the formability is significantly enhanced while a high room temperature tensile strength is maintained. It is shown by both laboratory measurements and plant trials that it is possible to warm form high strength aluminum sheet into complex parts. A brief discussion is given on some of the important materials and process considerations.</div>
How Do Teacher Affective and Cognitive Self-Concepts Predict How Do Teacher Affective and Cognitive Self-Concepts Predict Their Willingness to Teach Challenging Students? Their Willingness to Teach Challenging Students? (2019)

Building on and extending earlier research on student self-concepts and studies investigating teachers working with students with social, emotional, or behavioural difficulties, disorders, or disturbance, this longitudinal study examined teacher self-concepts in relation to their willingness to teach challenging students in mainstream classrooms. In the current study, “challenging students” refer to those who may pose a challenge to the teacher, either behaviourally or academically. Statistical measures included analysis of variance, correlation analysis, path analysis, and commonality analysis. Survey data collected from 108 participants at three different time points consistently showed that affective self-concept was a stronger predictor than cognitive self-concept of teachers’ willingness to teach challenging students. This study affirms and extends self-concept research by showing that the affective dimension of teacher self-concept is a better predictor of choice indicators than the cognitive dimension. The study also highlights the importance of developing and sustaining a strong sense of professional enjoyment for teachers in facing challenging teaching environments.
OpenGL volumizer: a toolkit for high quality volume rendering of large data sets (2002)

We present the OpenGL Volumizer API for interactive, high-quality, scalable visualization of large volumetric data sets. Volumizer provides a high-level interface to OpenGL hardware to allow application writers and researchers to visualize multiple gigabytes of volumetric data. Use of multiple graphics pipes scales rendering performance and system resources including pixel-fill rate and texture memory size. Volume roaming and multi-resolution volume rendering provide alternatives for interactive visualization of volume data. We combine the concepts of roaming and multi-resolution to introduce 3D Clip-Textures, an efficient technique to visualize arbitrarily large volume data by judiciously organizing and paging them to local graphics resources from storage peripherals. Volumetric shaders provide an interface for high quality volume rendering along with implementing new visualization techniques. This paper gives an overview of the API along with a discussion of large data visualization techniques used by Volumizer.
Nonthermal plasma technology for organic destruction (1995)

Pacific Northwest Laboratory (PNL) is investigating the use of nonthermal, electrically driven plasmas for destroying organic contaminants near ambient temperatures and pressures. Three different plasma systems have been developed to treat organics in air, water, and soil. These systems are the Gas-Phase Corona Reactor (GPCR)III for treating air, the Liquid-Phase Corona Reactor for treating water, and In Situ Corona for treating soils. This presentation focuses on recent technical developments, commercial status, and project costs of OPCR as a cost-effective alternative to other air-purification technologies that are now in use to treat off-gases from site-remediation efforts as well as industrial emissions.
Kinetics of Acid-Hydrolysis of Nickel(II) and Copper(II) Compounds With the Cyclic Diamines 1,5-Diazocane and 4,4-Dimethyl-7-(5,5,7-trimethyl-1,4-diazepan-1-Yl)-5-azaheptan-2-ol (1989)

The kinetics of acid-promoted hydrolysis reactions of nickel(II) and copper(ll) complexes of the cyclic diamines 1,5-diazocane ( daco ) and 4,4-dimethyl-7-(5,5,7-trimethyl-1,4-diazepan-1-yl)-5-azaheptan-2-ol (pyaz) in NaCl/HCl media ([Cl-] = 2 mol dm-3) are reported. For [Ni( daco )2]2+, beyond small [H+], an acid-limited rate constant of 2.0×10-5 S-l, involving dissociation of the first daco ligand, and for [Cu( daco )2]2+ a similarly acid-limited rate constant of 1.5×10-2 s-l, involving dissociation of the second daco ligand, were measured at 50°C. For [Ni( pyaz )]2+ and [Cu ( pyaz )2+ the rates of the hydrolysis reactions are again acid-limited, effectively independent of acid with rate constant of 1.0×10-2 s-1 for [Ni( pyaz )]2+ while for [Cu( pyaz )]2+ the rate follows the expression kobs , = 6.0×10-2[H+]/(l+4.6[H+]) S-l, both measured at 25°C.