gebhart/patrepeval huggingface dataset:
Cardiac disease after mediastinal irradiation for seminoma (1987)

One hundred twenty-four patients with seminoma (119 primary testis, five primary extragonadal) were treated between 1968 and 1984 at the Joint Center for Radiation Therapy. Fifty-seven of the 124 patients were treated with irradiation to the mediastinum as well as to an infradiaphragmatic field. One patient received supradiaphragmatic radiotherapy only. The remaining patients had radiation treatment limited to the infradiaphragmatic field only. Median dose to the mediastinum among the 58 patients was 2400 cGy. Four patients developed heart disease (one fatal myocardial infarction, one uncomplicated myocardial infarction, one constrictive pericarditis resulting in permanent total body anasarca, and one patient requiring aortic valve replacement and coronary artery bypass grafting for atherosclerotic disease) and two died suddenly. The two sudden deaths were thought to be cardiac in origin by the patient's primary physicians. All six complications occurred in the group that received mediastinal irradiation. No cardiac disease was manifested in the group not treated with mediastinal irradiation. This difference in the incidence of cardiac disease between the two groups is statistically significant (two sided, P = 0.019). Neither group had a statistically significant difference in cardiac disease rate from a normal population (Framingham study), although the ratio of observed to expected cardiac disease was 1.97 in the group receiving mediastinal radiation. Further experience from this and other institutions is necessary to confirm this finding.
Lectin Affinity Plasmapheresis for Middle East Respiratory Syndrome-Coronavirus and Marburg Virus Glycoprotein Elimination (2018)

MERS-CoV (pseudovirus) and MARV soluble GPs are eliminated by LAP in vitro. Considering the high lethality and missing established treatment options, LAP should be evaluated in vivo. Especially early initiation, continuous therapy, and timed cartridge exchanges could be of importance.
Joint Motion and Reflectance Capture for Creating Relightable 3D Videos (2005)

Passive optical motion capture is able to provide authentically animated, photo-realistically and view-dependently textured models of real people. To import real-world characters into virtual environments, however, also surface reflectance properties must be known. We describe a video-based modeling approach that captures human motion as well as reflectance characteristics from a handful of synchronized video recordings. The presented method is able to recover spatially varying reflectance properties of clothes by exploiting the time-varying orientation of each surface point with respect to camera and light direction. The resulting model description enables us to match animated subject appearance to different lighting conditions, as well as to interchange surface attributes among different people, e.g. for virtual dressing. Our contribution allows populating virtual worlds with correctly relit, real-world people.
CO Insertion of (η<sup>3</sup>-allyl)Fe(CO)<sub>2</sub>(NO) Complexes by Diphosphines (1996)

Allyl groups of (η3-allyl)Fe(CO)2(NO) complexes undergo regioselective cabonylation at the less substituted carbon of the η3-allyl ligands in the presence of 1,2-bis(diphenylphosphino)ethane to give (β,γ-unsaturated acyl)Fe(CO)(NO)(dppe) complexes in good yields. X-ray analysis of the acyl complex thus obtained revealed that the complex has a trigonal bipyramid geometry. A characteristic substituent effect of the η3-allyl ligands on the CO insertion reaction was observed.
Challenges and lessons learned in building a practical smart space (2004)

Ubiquitous computing as the integration of sensors, middleware, and networking technologies to form a "smart space" environment relies on the development of both software and hardware solutions. For over 3 years, our group has been developing a smart-space environment, involving the exploration of core technologies and attractive applications. We introduce the challenges faced and lessons learned in designing and developing a smart-space environment, including device control services, locating systems, wireless sensor nodes, and middleware services.
System for matching paintings with music based on emotions (2016)

People experience various emotions when they interact with artistic content such as music and visual art in the form of paintings. Thus, painters and composers use features in music and paintings to influence people emotionally. An analysis of methods employed to create features to influence people using paintings and music indicated that people apparently do not find it difficult to understand artistic content. When people view paintings, listening to music that creates a mood similar to that portrayed by the paintings could be helpful to understand the painter's intention.
AI and computer power (1994)

AI and simulation, Ray Paul new concepts in data analysis - modal objects for knowledge analysis, E. Diday simulation of uncertainty - decision support in complex incompletely defined environments, Michael con Rimscha statistics and computing - the promise and the risk, D. Hand are there any lessons to be learnt from the building of GLIMPSE?, Carl O'Brien handling imprecisely-known conditional probabilities, S. Amarger et al combining symbolic and numerical methods for reasoning under uncertainty, Paul Krause and John Fox computationally intensive methods in the design of experiments, A. Atkinson FRIL - a support logic programming system, J. Baldwin et al computational models of diagnostic reasoning, A. Gammerman a general numerical approach to the benchmark problems in defeasible reasoning, S. Roehrig on the path to practical probabilistic reasoning, S. Kimbrough and F. Roehrig.
Issues in Electronic Publishing Using Optical Disc Technology (1988)

No abstract available for this article.
Coherent Epitaxial Semiconductor-Ferromagnetic Insulator InAs/EuS Interfaces: Band Alignment and Magnetic Structure (2019)

Hybrid semiconductor-ferromagnetic insulator heterostructures are interesting due to their tunable electronic transport, self-sustained stray field and local proximitized magnetic exchange. In this work, we present lattice matched hybrid epitaxy of semiconductor - ferromagnetic insulator InAs/EuS heterostructures and analyze the atomic-scale structure as well as their electronic and magnetic characteristics. The Fermi level at the InAs/EuS interface is found to be close to the InAs conduction band and in the bandgap of EuS, thus preserving the semiconducting properties. Both neutron and X-ray reflectivity measurements show that the ferromagnetic component is mainly localized in the EuS thin film with a suppression of the Eu moment in the EuS layer nearest the InAs. Induced moments in the adjacent InAs layers were not detected although our ab initio calculations indicate a small exchange field in the InAs layer. This work presents a step towards realizing high quality semiconductor - ferromagnetic insulator hybrids, which is a critical requirement for development of various quantum and spintronic applications without external magnetic fields.
Major Hepatic Resection A 25-Year Experience (1983)

Major hepatic resections were performed on 138 patients for a variety of conditions. There was one intraoperative death. Including this patient, there were 15 deaths within 30 days of the operation (operative mortality 10.9%). Important postoperative complications were intra-abdominal sepsis (17%), biliary leak (11%), hepatic failure (8%), and hemorrhage (6%). The results of 30 resections for the benign lesions, liver cell adenoma, focal nodular hyperplasia, hemangioma, and cystadenoma showed no operative mortality and low morbidity. Of 26 patients with hepatocellular carcinoma, seven died within a month of operation. The cumulative survival of the 26 at five years was 38%, and of the 19 who survived the procedure, 51%. Poor survival followed resections for cholangiocarcinoma and "mixed tumors." The five-year cumulative survival of 22 patients who had colorectal metastases excised was 31%. Apart from a patient with carcinoid, prolonged survival was rare after resection of other secondaries and after en bloc resections for tumors directly invading the liver. Hepatic resection was of value in the management of some patients with hepatic trauma, Caroli's disease, liver cysts, and intrahepatic stones.
Respiratory effects in human functional magnetic resonance imaging due to bulk susceptibility changes (2001)

Functional magnetic resonance imaging relies on detecting small changes in the signal in the presence of noise from various sources. It has been shown that periodic variations in the signal at the respiratory frequency occur in the brain and various techniques have been proposed to remove them. However, the precise mechanism by which respiration affects the fMRI signal has not yet been proven. Here, we explore the nature of respiratory signal variations and the artefacts they produce in brain images. Our results demonstrate conclusively that bulk susceptibility variations in the lungs during respiration cause variations in the static magnetic field within the brain tissue. These variations in field strength and homogeneity lead to a shift of the image and a shading of image intensity in the phase encoding direction. These artefacts, if left uncorrected, may lead to the production of spurious activations and/or decreased statistical significance of true activations in fMRI. In addition, these results suggest that respiration effects may not necessarily be well characterized as simple additive noise and that an alternative model based on the physical origins of susceptibility variations may be more appropriate.
A brief appraisal of computational modeling of antimicrobial peptides’ activity (2018)

We present a brief overview of computer simulations over the span of last two decades that have made some serious attempts in providing key insights toward the mechanistic aspects of antimicrobial peptides and biomimetic peptides. We review some of the success stories of computational modeling of antimicrobial activity and also point toward the present shortcomings of the current approaches. Finally, we shed light upon the future potential directions that computational approach can adopt toward direct and closer comparisons with experiments on antimicrobial activity.
Adenovirus Composition, Proteolysis, and Disassembly Studied by In-depth Qualitative and Quantitative Proteomics (2014)

Using high-resolution MS-based proteomics in combination with multiple protease digestion, we profiled, with on average 90% sequence coverage, all 13 viral proteins present in an human adenovirus (HAdV) vector. This in-depth profile provided multiple peptide-based evidence on intrinsic protease activity affecting several HAdV proteins. Next, the generated peptide library was used to develop a targeted proteomics method using selected reaction monitoring (SRM) aimed at quantitative profiling of the stoichiometry of all 13 proteins present in the HAdV. We also used this method to probe the release of specific virus proteins initiated by thermal stimulation, mimicking the early stage of HAdV disassembly during entry into host cells. We confirmed the copy numbers of the most well characterized viral capsid components and established the copy numbers for proteins whose stoichiometry has so far not been accurately defined. We also found that heating HAdV induces the complete release of the penton base and fiber proteins as well as a substantial release of protein VIII and VI. For these latter proteins, maturational proteolysis by the adenoviral protease leads to the differential release of fragments with certain peptides being fully released and others largely retained in the AdV particles. This information is likely to be beneficial for the ongoing interpretation of high resolution cryoEM and x-ray electron density maps.
[Clinical and radiologic study of hereditary diseases of the femoral epiphysis]. (1992)

The diseases that involve the proximal femoral epiphysis are an heterogeneous group with similar clinical characteristics, so it is important to establish a differential diagnosis to bring suitable management and genetic counseling. The present study includes 33 patients: eleven with multiple epiphyseal dysplasia (MED), five with spondylo-epiphyseal dysplasia (SED), twelve with unilateral Perthes disease (PD uni) and five with bilateral Perthes disease (PD bi). The clinical study showed that affected relatives and associated clinical manifestations were more frequent in the dysplastic patients. The somatometric profile of the 17 PD patients was within two standard deviations of the average, whereas the dysplastic patients showed short stature. In the radiological study all patients had one or both proximal femoral epiphysis affected. All the dysplastic patients had other irregular or flattened epiphysis, but only half of those with PD showed mild flattening or distal femoral epiphysis. Eight of 29 patients had a delay in bone maturity, and all patients had mild flattened vertebras. We think this study shows the importance of having sufficient clinic and radiologic criteria to establish the differential diagnosis in view of the heterogeneity of these entities.
A weakest precondition approach to active attacks analysis (abstract only) (2009)

Information flow controls can be used to protect both data confidentiality and data integrity. The certification of the security degree of a program that runs in untrusted environments still remains an open problem in language-based security. The notion of robustness asserts that an active attacker, who can modify program code in some fixed points (holes), is not able to disclose more private information than a passive attacker, who merely observes public data. In this paper, we extend a method recently proposed for checking declassified non-interference in presence of passive attackers only, in order to check robustness by means of the weakest precondition semantics. In particular, this semantics simulates the kind of analysis that can be performed by an attacker, i.e., from the public output towards the private input. The choice of the semantics lets us distinguish between different attacks models. In this paper, we also introduce relative robustness that is a relaxed notion of robustness for restricted classes of attacks.
Methods for the asymmetric preparation of amines (1995)

A. Johansson, Contemp. Org. Synth., 1995, 2, 393 DOI: 10.1039/CO9950200393
The p75NTR extracellular domain (2011)

Senile plaques composed of amyloid-beta (Aβ) in the brain are one of the hallmarks of Alzheimer disease (AD). Removal of Aβ from the brain is the most important therapeutic strategy for AD. The solubility of Aβ is critical for its endocytosis, transcytosis and removal from the brain. Our recent study has found that the extracellular domain of p75NTR, the neurotrophin receptor, plays an important role in the solubility of Aβ and might be one of the endogenous mechanisms in the regulation of Aβ plaque formation. The physiologically shedded extracellular domain of p75NTR is able to inhibit Aβ aggregation and diasggregate preformed Aβ fibrils, while the full p75NTR expressed on neurites, endothelial cells and smooth muscle cells in blood-brain barrier (BBB) might initiate Aβ endocytosis and degradation, and/or remove Aβ from the brain via BBB. Understanding the roles of p75NTR in the solubility and clearance of Aβ may allow targetting p75NTR as a unique opportunity to develop therapeutic drugs for the prevention and treatment of AD.
Improvement of (1122) Semipolar GaN Crystal Quality with TiN Interlayer by Metal Organic Vapor Phase Epitaxy (2011)

The effect of a TiN interlayer on the crystalline quality of (1122) semipolar GaN grown on m-plane sapphire was studied by high-resolution X-ray diffraction (HRXRD). Before GaN growth, a TiN interlayer was formed by nitrided the Ti metal on the GaN seed layer. Symmetric and skew-symmetric HRXRD measurements demonstrate that both threading dislocation and basal plane stacking fault densities are reduced. Raman results also show an increased crystalline quality and a decreased threading dislocation density. (1122) semipolar GaN with an optimal Ti thickness of 2 nm has been obtained under the existing growth conditions.
Oncolytic Viral Therapy for Prostate Cancer: Efficacy of Reovirus as a Biological Therapeutic (2010)

Reovirus is a nonattenuated double-stranded RNA virus that exploits aberrant signaling pathways allowing selective cytotoxicity against multiple cancer histologies. The use of reovirus as a potential treatment modality for prostate cancer has not previously been described, and in this study evidence of in vitro and in vivo activity against prostate cancer was seen both in preclinical models and in six patients. The human prostate carcinoma cell lines PC-3, LN-CaP, and DU-145 exposed to replication-competent reovirus showed evidence of infection as illustrated by viral protein synthesis, cytopathic effect, and release of viral progeny. This oncolytic effect was found to be manifested through apoptosis, as DNA fragmentation, Apo 2.7 expression, Annexin V binding, and poly(ADP-ribose) polymerase cleavage were observed in live reovirus-infected cells, but not in uninfected or dead virus-treated cells. In vivo, hind flank severe combined immunodeficient/nonobese diabetic murine xenograft showed reduction in tumor size when treated with even a single intratumoral injection of reovirus. Finally, intralesional reovirus injections into a cohort of six patients with clinically organ-confined prostate cancer resulted in minimal side effects and evidence of antitumor activity. Histologic analysis after prostatectomy found a significant CD8 T-cell infiltration within the reovirus-injected areas as well as evidence of increased caspase-3 activity. These findings suggest that reovirus therapy may provide a promising novel treatment for prostate cancer and also imply a possible role for viral immune targeting of tumor.
Ethane-Based Chemical Amplification Measurement Technique for Atmospheric Peroxy Radicals (2016)

Peroxy radicals play important roles in the atmospheric oxidation of organic compounds and the formation of ozone and secondary organic aerosol. There are few peroxy radical measurement techniques; the most common, chemical amplification using CO and NO, requires the use of toxic reagents, and its calibration factor is very sensitive to relative humidity. We present a new method for quantifying atmospheric peroxy radicals, ECHAMP (Ethane CHemical AMPlifier). Sampled air is mixed with NO and C2H6 (rather than CO), effecting a series of reactions that ultimately produces 25 molecules of NO2 per sampled peroxy radical under dry conditions. This “amplification” factor decreases to 17 at a relative humidity of 50%, yielding a 1σ precision for 90 s average measurements of 0.8–2.5 ppt depending on the atmospheric variability of ozone. We demonstrated the utility of the new technique with measurements in Bloomington, IN, in July 2015.
A Survey of Real‐Time Hard Shadow Mapping Methods (2011)

Abstract Because of its versatility, speed and robustness, shadow mapping has always been a popular algorithm for fast hard shadow generation since its introduction in 1978, first for offline film productions and later increasingly so in real‐time graphics. So it is not surprising that recent years have seen an explosion in the number of shadow map related publications. Because of the abundance of articles on the topic, it has become very hard for practitioners and researchers to select a suitable shadow algorithm, and therefore many applications miss out on the latest high‐quality shadow generation approaches. The goal of this survey is to rectify this situation by providing a detailed overview of this field. We show a detailed analysis of shadow mapping errors and derive a comprehensive classification of the existing methods. We discuss the most influential algorithms, consider their benefits and shortcomings and thereby provide the readers with the means to choose the shadow algorithm best suited to their needs.
Synthesis of peptide analogs of the N-terminal eicosapeptide sequence of ribonuclease A. XII. Synthesis of des-Lys1-[Orn10]-, and des-Lys1,Glu2,Thr3-[Orn10]-S-peptides1,2 (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of peptide analogs of the N-terminal eicosapeptide sequence of ribonuclease A. XII. Synthesis of des-Lys1-[Orn10]-, and des-Lys1,Glu2,Thr3-[Orn10]-S-peptides1,2Luigi Moroder, Fernando Marchiori, Raniero Rocchi, Angelo Fontana, and Ernesto ScoffoneCite this: J. Am. Chem. Soc. 1969, 91, 14, 3921–3926Publication Date (Print):July 1, 1969Publication History Published online1 May 2002Published inissue 1 July 1969https://pubs.acs.org/doi/10.1021/ja01042a040https://doi.org/10.1021/ja01042a040research-articleACS PublicationsRequest reuse permissionsArticle Views28Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Silibinin activates p53-caspase 2 pathway and causes caspase-mediated cleavage of Cip1/p21 in apoptosis induction in bladder transitional-cell papilloma RT4 cells: evidence for a regulatory loop between p53 and caspase 2 (2006)

Silibinin, a natural flavonolignan, induces apoptosis in human bladder transitional-cell papilloma RT4 cells both in vitro and in vivo; however, mechanisms of such efficacy are not completely identified. Here, we studied the mechanisms involved in silibinin-induced apoptosis of RT4 cells having intact p53. Silibinin increased p53 protein level together with its increased phosphorylation at serine 15, activated caspase cascade and caused Bid cleavage for apoptosis. Silibinin-caused p53 activation was mediated via ATM-Chk2 pathway, which in turn induced caspase 2-mediated apoptosis. Pifithrin-alpha, a p53 inhibitor, reversed silibinin-induced caspase activation including caspase 2; however, caspase 2 inhibitor also reversed p53 phosphorylation suggesting a bidirectional regulation between them. Further, silibinin caused a rapid translocation of p53 and Bid into mitochondria leading to increased permeabilization of mitochondrial membrane and cytochrome c release into the cytosol. JNK1/2 activation was observed as a connecting link for p53-mediated caspase 2 activation. Interestingly, silibinin-induced apoptosis was mediated, in part, via Cip1/p21 cleavage by caspase, which was reversed by Cip1/p21 siRNA. Together, these results suggested the novel mechanisms for apoptosis induction by silibinin involving p53-caspase 2 activation and caspase-mediated cleavage of Cip1/p21.