gebhart/patrepeval huggingface dataset:
Mapping the Mitomycin Biosynthetic Pathway by Functional Analysis of the MitM Aziridine <i>N</i>-Methyltransferase (2001)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTMapping the Mitomycin Biosynthetic Pathway by Functional Analysis of the MitM Aziridine N-MethyltransferaseMustafa Varoglu, Yingqing Mao, and David H. ShermanView Author Information University of Minnesota, Department of Microbiology and Biological Process Technology Institute 1460 Mayo Memorial Building, MMC 196 420 Delaware Street Southeast, Minneapolis, Minnesota 55455 Cite this: J. Am. Chem. Soc. 2001, 123, 27, 6712–6713Publication Date (Web):June 14, 2001Publication History Received8 February 2001Revised10 May 2001Published online14 June 2001Published inissue 1 July 2001https://pubs.acs.org/doi/10.1021/ja015646lhttps://doi.org/10.1021/ja015646lrapid-communicationACS PublicationsCopyright © 2001 American Chemical SocietyRequest reuse permissionsArticle Views609Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Alkyls,Aziridines,Biosynthesis,Organic reactions,Peptides and proteins Get e-Alerts
Luminescent photoelectrochemical cells. 6. Spatial aspects of the photoluminescence and electroluminescence of cadmium selenide electrodes (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLuminescent photoelectrochemical cells. 6. Spatial aspects of the photoluminescence and electroluminescence of cadmium selenide electrodesHolger H. Streckert, Jiuru Tong, and Arthur B. EllisCite this: J. Am. Chem. Soc. 1982, 104, 2, 581–588Publication Date (Print):January 1, 1982Publication History Published online1 May 2002Published inissue 1 January 1982https://pubs.acs.org/doi/10.1021/ja00366a036https://doi.org/10.1021/ja00366a036research-articleACS PublicationsRequest reuse permissionsArticle Views91Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Effect of Diet on Populations of Three Species of Ruminal Cellulolytic Bacteria in Lactating Dairy Cows (1999)

The effects of four contrasting diets were determined on populations of three species of ruminal cellulolytic bacteria (Ruminococcus albus, Ruminococcus flavefaciens, and Fibrobacter succinogenes) using oligonucleotide probes to rRNA. Diets based on alfalfa silage or corn silage as the primary fiber source were formulated to contain either 24 or 32% neutral detergent fiber measured after alpha-amylase treatment. The diets were fed twice daily to four ruminally fistulated, lactating Holstein cows in a trial using a Latin square design. The cows fed the alfalfa silage diets had higher dry matter intakes and milk production and smaller pH fluctuations than did cows fed the corn silage diets (0.3 vs. 0.8 units). The total populations of the three cellulolytic species at 3 h after feeding ranged from 0.3 to 3.9% of the bacterial domain; R. albus was generally the most abundant of the three species. The data are in general agreement with population assessments obtained by some traditional methods of culture enumeration. Although diet and individual cows had major effects on ruminal pH and volatile fatty acid concentrations and on milk production and composition, differences in cellulolytic populations that were attributable to individual cows were larger than those attributable to diet, suggesting that each cow maintained a unique assemblage of cellulolytic species.
Zur optimierung der Polymerfraktionierung auf der Grundlage von Lösungsgleichgewichten in Lösungsmittel‐Fällungsmittel‐Systemen (1970)

Abstract Da das Entmischungsverhalten verdünnter polydisperser Lösungen im wesentlichen durch die Partialkonzentrationen der einzelnen Polymerkomponenten bestimmt wird, kann die Polymerfraktionierung auf der Basis des Fällungsverhaltens von Eichfraktionen und ihrer Mischungen mit Hilfe eines Löslichkeitsdiagramms (CLAESSON‐Diagramm) beschrieben werden. Es kann zunächst gezeigt werden, daß die charakteristischen Merkmale der Fällfraktunmerung durch das Löslichkeitsdiagramm richtig wiedergegeben werden. Das Diagramm erlaubt dann in einfacher Weise, den Einfluß der Variation der einzelnen Verfahrensparameter (Konzentration, Schrittbreite δγ, Verfahrensschema, Temperatur und Lösungsmittel/Fällungsmittel‐(L/F‐)System) auf die Einheitlichkeit einer Fraktion wiederzugeben. Diese Ergebnisse entsprechen zum einen‐wie z. B. bezüglich der Konzentrationsabhängigkeit‐den bekannten experimentellen Erfahrungen. Zum anderen können darüber hinaus erstmals definierte Aussagen zum Einfluß der Temperatur und der Auswahl des L/F‐Systems gemacht werden. Danach ist die Wahl der Temperatur für den Trenneffekt unerheblich. Die übliche qualitative Charakterisierung von Lösungsmittel und Fällungsmittel durch „gut”︁ und „schlecht”︁ ist als Auswahlkriterium unzureichend, teilweise sogar irreführend, da kein Zusammenhang zwischen diesen Angaben und der Form des Löslichkeits‐diagramms besteht. Auf der Grundlage der Analyse der Einzelparameter können die optimalen Arbeitsbedingungen zur Gewinnung einer möglichst einheitlichen Fällfraktion angegeben werden.
Competence‐based vocational training: ten years on and still down the wrong path? (1996)

Begins by reviewing technical progress towards establishment of an effective and standardized, competence‐based vocational education and training system, and compares this progress with the system in Germany. Describes a number of respects in which the system is failing to meet its objectives. Certain stakeholders are happier with the new approach than others. Also describes the political agenda behind the introduction of competence‐based training, and compares the individualist, business‐centred policy in Britain with the more collaborative approach in Germany. Britain’s policy towards training is consistent with its policy towards the Social Chapter. Concludes that unless the political agenda is changed, regardless of any technical improvements made, retention of the current policy will consign Britain to a low‐skill competitive position with respect to the rest of Europe.
Routine Methods in Toxicology and Therapeutic Drug Monitoring by High Performance Liquid Chromatography (1987)

A highly specific, sensitive, and rapid microscale method is described for determining furosemide levels in plasma and urine. Monitoring furosemide levels has been recommended in patients with impaired renal function and in premature infants since furosemide has been known to cause ototoxicity. The method described here is simple, easy to run, takes only 7 min per sample, and can be set up for routine monitoring of furosemide by clinical laboratories. The method uses ion-pairing high performance liquid chromatography and detection of furosemide by fluorescence, which gives excellent separation and high sensitivity with minimal sample preparation. The method requires only 25 microliters of plasma or urine and, thus, is suitable for use in newborn intensive care units.
Using WorldView-2 Vis-NIR multispectral imagery to support land mapping and feature extraction using normalized difference index ratios (2012)

Multispectral imagery (MSI) provides information to support decision making across a growing number of private and industrial applications. Among them, land mapping, terrain classification and feature extraction rank highly in the interest of those who analyze the data to produce information, reports, and intelligence products. The 8 nominal band centers of WorldView-2 allow us to use non-traditional means of measuring the differences which exist in the features, artifacts, and surface materials in the data, and we can determine the most effective method for processing this information by exploiting the unique response values within those wavelength channels. The difference in responses across select bands can be sought using normalized difference index ratios to measure moisture content, indicate vegetation health, and distinguish natural features from man-made objects. The focus of this effort is to develop an approach to measure, identify and threshold these differences in order to establish an effective land mapping and feature extraction process germane to WorldView-2 imagery.
Effect of ion energy upon dielectric breakdown of the capacitor response in vertical power MOSFETs (1998)

The effect of ion energy upon the ion-induced dielectric breakdown response of the capacitor response in vertical power metal-oxide semiconductor field effect transistors (MOSFETs) was investigated. The single event gate rupture response was experimentally determined using mono-energetic ion beams of copper, niobium, and gold. Irradiations were conducted using an ion species tuned to different energies, producing a range of linear energy transfer (LET) values for that ion. Numerous MOSFETs were characterized to identify the onset of ion-induced dielectric breakdown. These data along with previously taken data demonstrated that the ion-induced dielectric breakdown cannot be adequately described in terms of LET, but is better described in terms of atomic number (Z). Based upon these observations, a new semi-empirical expression is presented describing the critical ion-induced breakdown response in terms of Z instead of LET. This expression is shown to be a better single event gate rupture model of the capacitor response.
Glutamine synthetase expression in activated hepatocyte progenitor cells and loss of hepatocellular expression in congestion and cirrhosis (2013)

Glutamine synthetase expression is increased in regenerating hepatocytes and in early HPCs prior to morphological evidence of hepatocellular differentiation. This may be the earliest marker of HPCs yet demonstrated. Loss of expression may be a reflection of disrupted endothelium-hepatocyte contact in hepatic vein walls caused by congestive injury as found in congestive heart failure and advanced cirrhosis.
Efficient synthesis of dimethyl carbonate from methanol, propylene oxide and CO<sub>2</sub>catalyzed by recyclable inorganic base/phosphonium halide-functionalized polyethylene glycol (2006)

The cycloaddition of propylene oxide and CO2 to form propylene carbonate promoted by a phosphonium salt covalently bound to polyethylene glycol (PEG), and the transesterification of propylene carbonate with methanol to dimethyl carbonate (DMC) mediated by PEG-supported K2CO3, were separately investigated. Inorganic base/phosphonium halide-functionalized PEG (K2CO3/BrBu3PPEG6000PBu3Br) was shown to be active for DMC synthesis from propylene oxide, CO2 and methanol under mild reaction conditions, even under low CO2 pressure (2 bar). The effects of various reaction variables on the activity and selectivity performance are discussed in detail. The catalyst was readily separated and reused, without catalyst leaching being detected by 31P NMR. Notably, excellent yields of DMC and complete conversion of propylene carbonate were reached under the optimized reaction conditions. This procedure was successfully applied to the synthesis of other dialkyl carbonates.
Intermittent Mandatory Ventilation (1974)

Twenty-four patients who had acute respiratory insufficiency necessitating mechanical ventilation were studied. Twelve patients had controlled mechanical ventilation (CMV) with T-tube trials of spontaneous ventilation to accomplish weaning. Twelve received intermittent mandatory ventilation (IMV), a method of mechanical ventilation that allows spontaneous respirations to occur but provides periodic mechanical hyperinflations. Weaning was accomplished by increasing the interval between mechanical breaths until the patient's ventilation was entirely spontaneous. Arterial blood gas tensions, pH, dead space to tidal volume ratio, oxygen consumption, vital capacity, and inspiratory force were monitored for all patients until weaning was complete. The functional residual capacity was reduced in all patients following mechanical ventilation. Controlled mechanical ventilation resulted in alkalosis, an increased ventilation time, and an increase in oxygen consumption compared to IMV.
Preparation and characterisation of a soy lecithin‐based self‐microemulsifying drug delivery system of resveratrol (2014)

The aim of this reported work was to develop and characterise a soy lecithin‐based self‐microemulsifying drug delivery system (SMEDDS) of resveratrol to enhance its oral delivery. Using high‐performance liquid chromatography, the solubility of resveratrol in various materials was determined. The effects and the ratios of the oil, surfactant and co‐surfactant on forming an efficient and stable SMEDDS were investigated using pseudo‐tertiary phase diagrams. The oil content, soy lecithin content and drug loading were optimised. The optimal formulation was composed of greoil gtcc, Cremophor EL, 1,2‐propanediol, soy lecithin and resveratrol (16.1/46/23/6.9/8, %w/w). The final SMEDDS was characterised by particle size, zeta potential and by transmission electron microscopy. The dilution volume in various aqueous media had some effect on the particle size. An in‐vitro release test showed a complete release of resveratrol from the SMEDDS in approximately 180 min. The stability investigation results indicated that the formulation was stable for 12 weeks.
Poly(Î²-hydroxyalkanoate) biosynthesis and accumulation by different<i>Rhizobium</i>species (1989)

Synthesis and accumulation of poly(β-hydroxy-alkanoate) in Rhizobium leguminosarum, R. leguminosarum biovar. trifolii, Rhizobium ‘galega’, Rhizobium ‘hedysarum’ and R. meliloti were studied. Poly(β-hydroxybutyrate) is accumulated up to 55% of the cell dry weight. At 30–50% air saturation R. meliloti accumulates 50% of its biomass (5.5 g·1−1 dry weight) as PHB after 90 h of batch fermentation. At 90% air saturation maximum accumulation (37.5%) of PHB occurs after 70 h cultivation. R. meliloti strain 41 is able to synthesize the copolymer poly(β-hydroxybutyrate-co-β-hydroxyvalerate) at concentrations up to 58% of the biomass dry weight, containing up to 22 mol% β-hydroxyvalerate. Different concentrations of both copolymer and hydroxyvalerate were obtained when the microorganism was grown, in batch culture, in the presence of propionate or valerate and with glucose, sucrose or succinate as main carbon source.
KAPow (2018)

In an FPGA system-on-chip design, it is often insufficient to merely assess the power consumption of the entire circuit by compile-time estimation or runtime power measurement. Instead, to make better decisions, one must understand the power consumed by each module in the system. In this work, we combine measurements of register-level switching activity and system-level power to build an adaptive online model that produces live breakdowns of power consumption within the design. Online model refinement avoids time-consuming characterization while also allowing the model to track long-term operating condition changes. Central to our method is an automated flow that selects signals predicted to be indicative of high power consumption, instrumenting them for monitoring. We named this technique KAPow, for ‘K’ounting Activity for Power estimation, which we show to be accurate and to have low overheads across a range of representative benchmarks. We also propose a strategy allowing for the identification and subsequent elimination of counters found to be of low significance at runtime, reducing algorithmic complexity without sacrificing significant accuracy. Finally, we demonstrate an application example in which a module-level power breakdown can be used to determine an efficient mapping of tasks to modules and reduce system-wide power consumption by up to 7%.
Filtered backprojection proton CT reconstruction along most likely paths (2013)

Improved spatial resolution was obtained in pCT images with filtered backprojection reconstruction using most likely path estimates of protons. The improvement in spatial resolution combined with the practicality of FBP algorithms compared to iterative reconstruction algorithms makes this new algorithm a candidate of choice for clinical pCT.
Quality of Cardiopulmonary Resuscitation Among Highly Trained Staff in an Emergency Department Setting (2006)

Highly trained professionals in an emergency department can achieve appropriate chest compression rates during CPR with a low hands-off ratio. Increased attention must be paid in all situations to the avoidance of hyperventilation.
Legislative issues related to breast cancer (1993)

Cancer is a political issue. Legislative decision-making as it relates to breast cancer must be driven by reliable scientific data and analysis. Carefully directed advocacy and responsible leadership can provide focus, resources, and enhancements for a beneficial impact on lives of breast cancer patients and potential patients.
Pressure Model of Soft Body Simulation (2004)

Motivated by existing models used for soft body simulation which are rather complex to implement, we present a novel technique which is based on simple laws of physics and gives high quality results in real-time. We base the implementation on simple thermodynamics laws and use the Clausius-Clapeyron state equation for pressure calculation. In addition, this provides us with a pressure force that is accumulated into a force accumulator of a 3D mesh object by using an existing spring-mass engine. Finally after integration of Newtons second law we obtain the behavior of a soft body with fixed or non-fixed air pressure inside of it.
Projections from the nucleus reuniens thalami to the entorhinal cortex, hippocampal field CA1, and the subiculum in the rat arise from different populations of neurons (1996)

The entorhinal cortex, CA1, and the subiculum receive a major input from the thalamic midline nucleus reuniens. At present, it is not known whether reuniens projections to these intimately interconnected regions are collateralized or arise from different cell populations. We employed the multiple fluorescent retrograde tracing technique with Fast Blue, Diamidino Yellow, and Fluoro-Gold to examine the possible collateralization of reuniens projections to the entorhinal cortex, CA1, and the subiculum. In addition, we studied the extent of collateralization within each target area. The results indicate that different, yet morphologically indistinguishable, populations of reuniens cells selectively innervate the entorhinal cortex, CA1, or subiculum. Within each of these areas, reuniens fibers display a locally restricted collateralization instead of distributing collaterals throughout the entire target structure. The rostal two-thirds of the nucleus reuniens is the major source of ipsilateral projections to CA1, subiculum, and entorhinal cortex. The perireuniens nucleus selectively projects to the perirhinal cortex. Reuniens projections to CA1 and medial entorhinal cortex originate in the dorsolateral part and throughout the medial one-half of the nucleus, respectively. For these two projections, no topography could be established. However, subicular afferents are topographically organized such that a dorsal-to-ventral gradient in the nucleus reuniens corresponds to a dorsal-to-ventral gradient along the subicular axis. Lateral entorhinal afferents display a subtle topography such that a lateral-to-medial shift of terminal fields in the lateral entorhinal cortex corresponds to a lateral-to-medial shift of projection neurons in the ventral nucleus reuniens.
Parallel Application Signature for Performance Analysis and Prediction (2014)

Predicting the performance of parallel scientific applications is becoming increasingly complex. Our goal was to characterize the behavior of message-passing applications on different target machines. To achieve this goal, we developed a method called parallel application signature for performance prediction (PAS2P), which strives to describe an application based on its behavior. Based on the application's message-passing activity, we identified and extracted representative phases, with which we created a parallel application signature that enabled us to predict the application's performance. We experimented with using different scientific applications on different clusters. We were able to predict execution times with an average accuracy greater than 97 percent.
Expression of matrilysin in vascular endothelial cells adjacent to matrilysin-producing tumors (1997)

Matrilysin is believed to play important roles in tumor progression and metastasis. In the present study, we analyzed matrilysin-producing cells in various human cancer tissues by immunohistochemistry and in situ hybridization. Tumor cells in colorectal carcinomas, pancreatic carcinomas, transitional-cell carcinomas of the kidney and small-cell lung carcinomas were frequently positive for matrilysin. In addition, we found that endothelial cells of arterioles and venules adjacent to matrilysin-positive tumors expressed matrilysin mRNA and protein. The endothelial cells adjacent to matrilysin-negative tumors and those in normal tissues were negative for matrilysin. Furthermore, analyses by casein zymography, Western blotting and RT-PCR showed that matrilysin was weakly expressed by cultured human umbilical vein endothelial cells. Our results suggest that the expression of matrilysin in vascular endothelial cells and in tumor cells may be regulated by common soluble factors, and that endothelial cell-derived matrilysin may contribute to tumor angiogenesis and tumor metastasis.
Structure and Syntheses of SEN-125 and Oxotomaymycin (1986)

The structure of SEN-215 was determined as !llaS)(E)-2-ethylidenee2,3,5,1O,11,11a-hexahydro-8-hydroxy-7methoxy-5-ono-1H-pyr1o10~2,l-~l~1,4lbenzodiazepine by conversion of ( E l and (2)-pretomayrnycin into ( E ) -and ( 2 ) -(51.2 ppml due to the same sterlc compression.