gebhart/patrepeval huggingface dataset:
Structural variations of O-linked oligosaccharides present in leukosialin isolated from erythroid, myeloid, and T-lymphoid cell lines. (1986)

Structuresof 0-linked oligosaccharides of leukosialin isolated from K562 erythroid, HL-60 promyelocytic, and HSB-2 T-lymphoid cell lines were examined.Leukosialin was isolated by specific immunoprecipitation from cells which were metabolically labeled with [3H]glucosamine, and glycopeptides were isolated after Pronase digestion.0-Linked oligosaccharides were released by alkaline borohydride treatment, and the structures of purified oligosaccharides were elucidated by specific exoglycosidase digestion, Smith degradation, and methylation anaylsis.Oligosaccharides from K562 cells were found to be GalNAcOH, Gal@1+ 3GalNAcOH, NeuNAca2+6GalNAcOH, NeuNAcaZ+ 3Galb1+3GalNAcOH, Gal/31+3(NeuNAcaZ+G)Gal- NAcOH, and NeuNAca2+3Gav1+3(NeuNAcaZ+ 6)GalNAcOH.On the other hand, oligosaccharides from HL-60 and HSB-2 cells were found to be Neu-NAca2+3Galj31+3GalNAcOH, NeuNAca2+3Gavl+ 4GlcNAc~1+6(Ga~1+3)GalNAcOH, Gal@1+4Glc-NAc@1+6(NeuNAca2+3Gal@1+3)GalNAcOH, and NeuNAca2+3Gal~1+4GlcNAc@1+6(NeuNAc~2+3-Galj31+3)GalNAcOH.These results clearly indicate that leukosialin can be differently glycosylated with 0-linked chains, and each erythroid or myeloid (and T-lymphoid) cell line expresses a characteristic set of 0-linked oligosaccharides which differ in core structures as well as in sialylation. ~ ~~~ ~In the preceding paper (I), we showed that various leukemic cell lines express a family of sialoglycoproteins which are closely related to each other.Although these glycoproteins isolated from different cell lines show significant differences in molecular weight, as estimated by SDS-polyacrylamide gel electrophoresis, their polypeptide portions appear to be very similar or the same, based on their size and reactivity with antibodies.These glycoproteins, termed leukosialin, were shown to contain a large number of 0-linked oligosaccharides and one asparagine-linked oligosaccharide/molecule (1).In this study, we present the evidence that the apparent differences in molecular weight of leukosialin in different cell lines are due to variations in 0-linked oligosaccharides; the
Synthesis of Stereodefined 3-Alkylideneoxindoles by Palladium-catalyzed Reactions of 2-(Alkynyl)aryl Isocyanates with Thiols and Alcohols (2009)

Abstract The palladium-catalyzed reactions of 2-(alkynyl)aryl isocyanates with thiols and alcohols caused cyclization to give stereodefined 3-alkylideneoxindoles incorporating sulfanyl and alkoxy groups on the alkylidene unit, respectively.
Experiences with blending HTTP, RTSP, and IMS [IP Multimedia Systems (IMS) Infrastructure and Services] (2007)

Although the session initiation protocol (SIP) based IMS network has attained attention for IP voice and video telephony networks, the popular and prevalent Web and streaming video applications are supported by real time streaming protocol (RTSP) and HTTP proxy networks. The current trend of maintaining disparate SIP-based IMS, RTSP, and HTTP proxy networks introduce added cost due to the duplication of network components, separate maintenance functions, and scaling inefficiency. Service providers' requirements to reduce such costs, call for the development of a solution that integrates the three proxy networks into a single hybrid platform. This article depicts the vision of such a hybrid platform, exemplified by two blended prototypes - shared streaming video application and the multimedia proxy. It is through the development of such applications that a path to an enhanced or extended IMS architecture encompassing the three proxy networks is possible. This article describes approaches promising the synthesis of IMS, HTTP, and RTSP based networks into integrated platforms that pioneer convergence to the vision. This article investigates a future, possible expansion of IMS to harmonize SIP, HTTP, and RTSP service delivery. The objective of this article is to initiate discussion and research
Assembly of cartilage proteoglycan with hyaluronate and structure of the central filament in proteoglycan aggregate (1990)

Conference Article| April 01 1990 Assembly of cartilage proteoglycan with hyaluronate and structure of the central filament in proteoglycan aggregate MATTHIAS MÖRGELIN; MATTHIAS MÖRGELIN 1Abteilung Biophysikalische Chemie, Biozentrum, CH-4056 Basel, Switzerland Search for other works by this author on: This Site PubMed Google Scholar MATS PAULSSON; MATS PAULSSON 1Abteilung Biophysikalische Chemie, Biozentrum, CH-4056 Basel, Switzerland Search for other works by this author on: This Site PubMed Google Scholar JÜRGEN ENGEL JÜRGEN ENGEL 1Abteilung Biophysikalische Chemie, Biozentrum, CH-4056 Basel, Switzerland Search for other works by this author on: This Site PubMed Google Scholar Author and article information Publisher: Portland Press Ltd Received: October 17 1989 Online ISSN: 1470-8752 Print ISSN: 0300-5127 © 1990 Biochemical Society1990 Biochem Soc Trans (1990) 18 (2): 204–207. https://doi.org/10.1042/bst0180204 Article history Received: October 17 1989 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation MATTHIAS MÖRGELIN, MATS PAULSSON, JÜRGEN ENGEL; Assembly of cartilage proteoglycan with hyaluronate and structure of the central filament in proteoglycan aggregate. Biochem Soc Trans 1 April 1990; 18 (2): 204–207. doi: https://doi.org/10.1042/bst0180204 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1990 Biochemical Society1990 Article PDF first page preview Close Modal You do not currently have access to this content.
Multimedia Metadata Processing: a Format Independent Approach (2005)

In multimedia applications, XML is being increasingly used to represent metadata; examples are MPEG-7 multimedia description schemes and MPEG-21 usage environment descriptions. As with the media data, the size of, or the overhead induced by, the XML metadata is important, particularly when used on constrained mobile devices. Therefore, compression (binary encoding) of the XML data becomes relevant to reduce this overhead. Within the MPEG-7 standardization effort, a Binary Format for Metadata (BiM) was developed, providing good compression efficiency and facilitating random access into, and manipulation of, the binary encoded bit stream. However, using binary encoded XML should not introduce interoperability issues with existing applications, nor add additional complexity to new applications. In this paper we investigate a solution for this issue by handling the binary encoded XML data by the XML parser. As such, applications do not need to be aware of the type of encoding of the XML data. In this paper, we introduce such an XML parser and evaluate its usability in different scenarios. We measure the memory requirements and compare the processing speed of parsing binary encoded XML to plain text XML.
The Effect of Vitamin-Mineral Supplementation on the Intelligence of American Schoolchildren: A Randomized, Double-Blind Placebo-Controlled Trial (2000)

This study confirms that vitamin-mineral supplementation modestly raised the nonverbal intelligence of some groups of Western schoolchildren by 2 to 3 points but not that of most Western schoolchildren, presumably because the majority were already adequately nourished. This study also confirms that vitamin-mineral supplementation markedly raises the non-verbal intelligence of a minority of Western schoolchildren, presumably because they were too poorly nourished before supplementation for optimal brain function. Because nonverbal intelligence is closely associated with academic performance, it follows that schools with children who consume substandard diets should find it difficult to produce academic performance equal to those schools with children who consume diets that come closer to providing the nutrients suggested in the U.S. RDA. The parents of schoolchildren whose academic performance is substandard would be well advised to seek a nutritionally oriented physician for assessment of their children's nutritional status as a possible etiology.
Synthesis of <scp>d</scp>/<scp>l</scp>-<i>erythro</i>-Sphingosine Using a TetheredAminohydroxylation Reaction as the Key Step (2009)

A diastereoselective synthesis of racemic d/l-erythro-sphingosine is described. The approach involves employing tethered­ aminohydroxylation (TA) to introduce the 2-amino and 3-hydroxy functions with required stereochemistry.
The principles and evolution of magnetic resonance imaging (2011)

Magnetic Resonance Imaging (MRI) offers the best textbook example for the exploitation of both Heike Kamerlingh Onnes's major discoveries, namely the liquefaction of liquid helium and superconductivity. This paper will briefly describe how MRI images are acquired, give a historical account about the early days, and then focus on the magnet. It provides a window into the world of physics and engineering of magnet technology and it will chart the magnet design evolution since inception. For example, over the past 20 years, magnet designers have taken 1.5T MRI magnets from a weight of 13tonnes and a length of 2.40m in 1989 to a weight of 3.2tonnes and a length of 1.37m in 2009. The 3T products have also undergone similar developments. Coils experience mechanical forces of order 380tonnes. The cryogenics for MRI magnets have also undergone major improvements. Today's magnets do not use liquid nitrogen and most importantly have zero helium loss, thus needing no refill. Combined with the weight, this makes the body scanner accessible to developing countries and easy to site in any room. Although the future may eliminate the need for liquid helium completely, MRI will always continue to depend on superconductivity.
Human Factors Engineering the TravTek Driver Interface (1991)

<div class="htmlview paragraph">The TravTek vehicle provides an information-rich multifunction environment for the driver, necessitating extensive teamwork in human factors engineering the displays and controls for efficient and safe operation. Example map and text screens are presented.</div>
The Structure of Nash Equilibrium in Repeated Games with Finite Automata (1988)

The authors study the Nash equilibria of a two-person, infinitely-repeated game in which players' preferences depend on repeated game payoffs and the complexity of the strategies they use. The model considered is that of A. Rubinstein (1986). Necessary conditions on the structure of the equilibria are derived. These results place significant restrictions on equilibrium payoffs. The results suggest that the introduction of implementation costs results in a striking discontinuity in the Nash equilibrium sets in terms of strategies and payoffs. Copyright 1988 by The Econometric Society.
[The vasa vasorum of the arteries]. (1996)

Nourishment of arteries is accomplished by diffusion from the lumen of the vessel and from vasa vasorum. Most normal arteries have an extensive network of vasa in the adventitia that arise from branch points of parent arteries. When the thickness of arteries exceeds the ability of simple diffusion of nutrients from the lumen (larger muscular of atherosclerotic arteries), vasa extend into the media and intima. Vasa in the intima-media arise predominantly from adventitial vasa, but can arise from the lumen in vascular grafts and recanalized arteries after thrombosis. Vasa respond to vasoactive stimuli, and can regress after they vascularize arterial grafts and in response to regression of the atherosclerotic lesions. Therefore, vasa can increase blood flow to the artery wall by dilation of existing arteries or by formation of new vessels (neovascularization). Conversely, vasa can reduce blood flow to the artery wall by active constriction or by regression (involution) of existing vasa. The pathophysiological significance of vasa vasorum in normal and diseased arteries is related to their structure. Vasa in the intima-media are thin-walled endothelial cell tubes with thin or absent medial smooth muscle cells. Therefore, they are prone to collapse and rupture in response to arterial pressure, mechanical forces in the artery, necrotic substances found in diseased arteries, and vasospasm. Vasa also provide the artery with a vast absorptive endothelial surface that may have important implications for arterial lipid kinetics, and delivery and removal of neurohumoral agents from the artery wall. These properties have lead to speculation about their role in the pathogenesis of atherosclerosis, plaque rupture and thrombosis, medial ischemia leading to arterial dissection and aneurysm, restenosis after angioplasty, and post-stenotic dilatation. Finally, larger veins also have an extensive network of vasa that have been implicated in the pathogenesis of venous thrombosis and varicose veins.
A privacy-aware compliance tracking system for skilled nursing facilities (2017)

In this paper, we report our experiences in designing, deploying, and making continuous improvements of a Privacy-Aware Compliance Tracking System (PACTS) at a skilled nursing facility. The purpose of PACTS is to help state tested nursing assistants (STNAs) get into the habit of using proper body mechanics when performing bedside cares. The system has been deployed in six resident rooms and seven STNAs have been participating our study for over ten weeks. This study makes the following contributions: (1) A registration mechanism that enables an STNA to register with any of the rooms that have PACTS installed, which is essential to protect the privacy of patients and non-participating persons; (2) A wrong activity detection mechanism that is robust against occlusions due to furniture and against temporary inability of floor determination; (3) A lease-based mechanism to improve the usability of PACTS, which allows an STNA to be continuously monitored without having to register with PACTS repeatedly when she/he goes in and out of the view of the Kinect sensor for the duration of the lease.
High resolution 3D image reconstruction in laminar optical tomography based on compressive sensing (2014)

Laminar optical tomography (LOT) combines the advantages of diffuse optical tomography image reconstruction and a microscopy-based setup to allow non-contact imaging at depth up to a few millimeters. However, LOT image reconstruction paradigm is inherently an ill-posed and computationally expensive inverse problem. Herein, we cast the LOT inverse problem in the compressive sensing (CS) framework to exploit the sparsity of the fluorophore yield in the image domain and to address the ill-posedness of the LOT inverse problem. We apply this new approach to thick tissue engineering applications. We demonstrate the enhanced resolution of our method in 3-D numerical simulations of anatomically accurate microvasculature and using real data obtained from phantom experiments. Furthermore, CS is shown to be more robust against the reduction of measurements in comparison to the classic methods for such application. Potential benefits and shortcomings of the CS approach in the context of LOT are discussed.
Group II phospholipase A<sub>2</sub> mRNA synthesis is stimulated by two distinct mechanisms in rat vascular smooth muscle cells (1990)

Two potent inflammatory mediators, interleukin 1 (IL-1) and tumor necrosis factor (TNF) as well as lipopolysaccharide (LPS) increased group II phospholipase A2 (PLA2) mRNA levels, which resulted in enhanced secretion of the PLA2 enzyme from rat smooth muscle cells. cAMP-elevating agents also stimulated the release of PLA2 and increased the mRNA, but IL-1, TNF and LPS did not affect cAMP levels. Furthermore, the effects of TNF and cAMP-elevating agents were not additive but synergistic. Therefore, we concluded that the level of rat group II PLA2 mRNA is controlled at least by two distinct mechanisms, one involves cAMP and the other is mediated by TNF, IL-1 and LPS. This study also suggests important roles of group II PLA2 in pathogenesis of vascular inflammation.
Studies on taxane synthesis. I. Synthesis of 3,8,11,11-tetramethyl-4-oxobicyclo[5.3.1]undecane as a model for taxane synthesis. (1988)

The bicyclo [5.3.1] undecanone 5 corresponding to the A and B rings in taxane diterpenes was synthesized from β-ionone.Reduction of the tosylhydrazone 11 with catecholborane afforded the trisubstituted olefin 12 having trans substituents at the C-1 and C-7 positions.The requisite cis-arrangement of these substituents for eight-membered ring formation was induced by epimerization of the aldehyde 13 to give the bicyclic hemiacetal 14.The lithium diisopropylamide-promoted intramolecular cyclization of the twelve-membered lactam sulfoxide 32 proceeded quite smoothly, affording the eight-membered keto sulfoxide 33 in quantitative yield.
Targeting hepatitis C virus translation: stopping HCV where it starts. (2003)

Hepatitis C virus (HCV) infection is an emerging global health concern. Combination therapy with pegylated interferon-alpha (INF alpha) and ribavirin results in approximately 60% sustained recovery. Of the non-responders, the majority are infected with genotype 1. As a consequence, improved therapeutics are necessary to enhance response rates, especially in genotype-1-infected individuals. HCV translation is mediated by an internal ribosome entry site (IRES) located within the 5' non-translated region. Recent studies have revealed that the HCV IRES recruits the cellular translation machinery in a distinct manner compared with cellular mRNA strategies. Therefore, screening assays can be developed to identify specific inhibitors of HCV translation as a possible treatment for HCV.
Dimerizations of electronegatively substituted dienes (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDimerizations of electronegatively substituted dienesF. J. WeigertCite this: J. Org. Chem. 1977, 42, 24, 3859–3863Publication Date (Print):November 1, 1977Publication History Published online1 May 2002Published inissue 1 November 1977https://pubs.acs.org/doi/10.1021/jo00444a013https://doi.org/10.1021/jo00444a013research-articleACS PublicationsRequest reuse permissionsArticle Views106Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
19.2 A self-interference-cancelling receiver for in-band full-duplex wireless with low distortion under cancellation of strong TX leakage (2015)

In-band full-duplex (FD) wireless communication, i.e. simultaneous transmission and reception at the same frequency, in the same channel, promises up to 2x spectral efficiency, along with advantages in higher network layers [1]. the main challenge is dealing with strong in-band leakage from the transmitter to the receiver (i.e. self-interference (SI)), as TX powers are typically >100dB stronger than the weakest signal to be received, necessitating TX-RX isolation and SI cancellation. Performing this SI-cancellation solely in the digital domain, if at all possible, would require extremely clean (low-EVM) transmission and a huge dynamic range in the RX and ADC, which is currently not feasible [2]. Cancelling SI entirely in analog is not feasible either, since the SI contains delayed TX components reflected by the environment. Cancelling these requires impractically large amounts of tunable analog delay. Hence, FD-solutions proposed thus far combine SI-rejection at RF, analog BB, digital BB and cross-domain.
Infusing engineering design into high school STEM courses (2011)

Society is recognizing the need to improve STEM education and introduce engineering design concepts before college. In the recent National Academy of Engineers report, Engineering in K-12 Education: Understanding the Status and Improving the Prospects, the authors suggest that the STEM disciplines not be treated as ―silos‖ and that engineering might serve as a motivating context to integrate the four STEM disciplines (Katehi, Pearson, & Feder, 2009). Recent research has suggested that integrated technology and engineering design curriculum can serve as a positive model for mathematics and science learning and retention (Ortiz, 2010; Wendell, 2011). The Tufts University Center for Engineering Education and Outreach (CEEO) strives to improve STEM education through engineering and believes every student should have the chance to engineer. Situated in Massachusetts, the first state to adopt engineering education at all levels in public schools (Massachusetts DOE, 2001), the CEEO supports the belief that engineering education starts in kindergarten and continues to develop throughout their K-12 schooling. We also believe that at the core of K-12 engineering is the Engineering Design Process (EDP). The purpose of introducing students to the EDP is not to have them ―build things‖, a common misconception. The EDP is meant to teach students that engineering is about organizing thoughts to improve decision making for the purpose of developing high quality solutions and/or products to problems. The knowledge and skills associated with the EDP are independent of the engineering discipline (e.g., mechanical, electrical, civil, etc.) and engineering science (e.g., thermodynamics, statics, or mechanics) knowledge that a particular engineering challenge may call upon. Design tasks therefore entail developing the kinds of critical thinking skills commonly associated with engineering and technology literacy. Three key concepts in successful implementation of the EDP are: students are engineers; teachers need to listen to their students; and classroom environments need to change to properly enable learning through the EDP.
A special-purpose computer for automatic target recognition (2003)

A description is given of Starloc (Sandia target Location computer) a special-purpose computer designed for automatic target recognition. It is motivated by the lock-and-tumbler (LAT) filter algorithm, a generalized matched filter that can detect targets regardless of variations in their appearance. Starloc's fault-tolerant structure of pipelined, parallel floating-point processors and memories efficiently performs two-dimensional correlation, the major computational kernel of the algorithm. The LAT filter algorithm correlates the input image with a set of ten to twenty filter kernels, each containing all of the information about the target and its variations, using a phase multiplexing scheme. Starloc implements the LAT algorithm correlations in the Fourier domain by transforming the image to the Fourier domain, performing pixel-by-pixel multiplication with a filter kernel represented in the domain, and then inverse-transforming the product. The last processing step is updating the target value for each pixel. Hot-standby processors and incorporating a comprehensive set of error checkers provide fault tolerance. A reduced-scale prototype has been constructed, and an advanced design using digital signal processors for increased speed is described.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>