gebhart/patrepeval huggingface dataset:
Diploidy of Drosophila imaginal cells is maintained by a transcriptional repressor encoded by escargot. (1994)

The Drosophila escargot (esg) gene encodes a C2-H2-type zinc finger protein that is expressed in the imaginal discs and histoblasts. In some esg mutants, the abdominal histoblasts become polyploid. It has therefore been suggested that the role of esg is to maintain diploidy of the imaginal cells. We show that esg encodes a DNA-binding protein with high affinity for G/ACAGGTG, the consensus-binding sequence for the basic helix-loop-helix (bHLH) family of transcription factors (E2 box). This DNA-binding activity is essential for esg function in vivo as the strong embryonic lethal allele esgVS8 is caused by an amino acid change within the zinc finger region, leading to reduced affinity for DNA. In cultured cells, a heterodimer of the bHLH proteins Scute and Daughterless activates transcription from promoters containing E2 boxes. The esg protein strongly inhibits this activation, suggesting that esg may regulate developmental processes dependent on bHLH proteins. In larvae, esg protein expressed by the heat shock promoter can rescue the polyploid phenotype of abdominal histoblasts, demonstrating that the phenotype is attributable to a loss of esg function. esg must be expressed continuously during the larval period for efficient rescue. Ectopic expression of esg in the salivary glands inhibits endoreplication of DNA. These results suggest that esg is involved in transcriptional inhibition of genes required for endoreplication.
A growing self-organizing algorithm for dynamic clustering (2002)

Presents a growing self-organizing algorithm for dynamic clustering. Controlling a signal counter of each cell, the network can grow. Also, if there exists undesired cell for the clustering, the cell can be deleted virtually. Our algorithm can reinforce the clustering function and the learned network can adapt flexibly to time-variant input space.
A System for the Analysis of Jet Engine Vibration Data (1999)

A system has been developed to extract diagnostic information from jet engine carcass vibration data. The system consists of a number of modules, each of which focuses on particular subsets of the data known to hold valuable information. Two of these
Evaluation of Cementing Practices by Quantitative Radiotracer Measurements (1986)

ABSTRACT A radiotracer technique has been developed that enables quantitative, foot-by-foot measurements of cement coverage behind casing. Based on uniform tagging of the entire cement column with short half life isotopes, this new technique enables measurements of cement placement, mud displacement, and the mixing that takes place at displacement fronts. The method was used in a study of cementing practices conducted in a series of East Texas wells. Radiotracer measurements were obtained that document cement coverage in wells drilled with 9-10 ppg (1080-1200 kg/m3) mud. Variables investigated include casing movement, casing attachments, and wellbore deviation.
An Architecture for Biometric Electronic Identification Document System Based on Blockchain † (2020)

This paper proposes an architecture for biometric electronic identification document (e-ID) system based on Blockchain for citizens identity verification in transactions corresponding to the notary, registration, tax declaration and payment, basic health services and registration of economic activities, among others. To validate the user authentication, a biometric e-ID system is used to avoid spoofing and related attacks. Also, to validate the document a digital certificate is used with the corresponding public and private key for each citizen by using a user’s PIN. The proposed transaction validation process was implemented on a Blockchain system in order to record and verify the transactions made by all citizens registered in the electoral census, which guarantees security, integrity, scalability, traceability, and no-ambiguity. Additionally, a Blockchain network architecture is presented in a distributed and decentralized way including all the nodes of the network, database and government entities such as national register and notary offices. The results of the application of a new consensus algorithm to our Blockchain network are also presented showing mining time, memory and CPU usage when the number of transactions scales up.
Researchers Nail Down Leptin Receptor (1996)

During the past 18 months, researchers have learned a great deal about what causes obesity, identifying first a hormone, called leptin, needed for normal weight maintenance, as well as a possible candidate for the hormone's receptor. Now three groups, one of which reports its findings on page 994 , have confirmed that they have indeed found the right receptor by showing that it's the product of the db gene, which has long been thought to encode the receptor for the weight-controlling hormone. What's more, they have shown how db mutations might lead to an inactive product—and grossly overweight mice as a result.
A new hybrid multi-level voltage-source converter with DC fault blocking capability (2010)

23/04/13 meb. Email sent asking for copyright and permission to add to spiral since its conference.. 24/04 emails ent requesting permission. 25/04/13 Meb Permission granted, ready to pub.
Optimal Loop-Unrolling Mechanisms and Architectural Extensions for an Energy-Efficient Design of Shared Register Files in MPSoCs (2006)

In this paper, we introduce a new hardware/software approach to reduce the energy of the shared register file in upcoming embedded architectures with several VLIW processors. This paper includes a set of architectural extensions and special loop unrolling techniques for the compilers of MPSoC platforms. This complete hardware/software support enables reducing the energy consumed in the register file of MPSoC architectures up to a 60% without introducing performance penalties.
The expression of the amyloid precursor protein (APP) is regulated by two GC-elements in the promoter (1992)

The structure of the promoter of the human APP gene resembles that of housekeeping genes, with the presence of a GC-rich region and the lack of a canonical TATA box. Since analysis of the expression of the APP gene, especially at the transcriptional level, might reveal factors or elements, which influence amyloid formation in Alzheimer's disease, a 5' deletion analysis of the APP promoter was performed, leading to the identification of an activating DNA fragment (Ac), acting also on a heterologous promoter. DNaseI-footprint analysis revealed three protected regions on the Ac fragment. Further gene transfer experiments showed, that at least two elements, designated A and C, confer transcriptional activity in HeLa cells. Whereas the proximal element A is a 19bp long GC-rich DNA sequence, the distal element C is a GC-palindrome with the sequence 5'GCGGCGCCGC.
ToF‐SIMS analysis of friction surfaces tested with mixtures of a phosphite and a friction modifier (2001)

Abstract The adsorption behaviour of a mixture of lubricant additives onto ferrous materials has been investigated by time‐of‐flight secondary ion mass spectrometry (ToF‐SIMS). Six mixtures were made by mixing one of two types of phosphites and one of three types of friction modifiers for subjecting to lubrication tests. By ToF‐SIMS analysis of the friction surfaces tested with these mixtures, the following conclusions were obtained. Adsorption of palmitic acid and glycerol monooleate was inhibited in the presence of phosphites, but the adsorption of oleyl amine was not inhibited by the phosphites. On the other hand, the reaction of tri‐ n ‐butylphosphite was inhibited in the presence of oleyl amine, but for other mixed systems no inhibition of the reaction of phosphites by a friction modifier was observed. Except for oleyl amine mixed systems, the amount of reaction product of the phosphites was found to be correlated to the lubrication properties for all of the other mixture systems. Copyright © 2001 John Wiley & Sons, Ltd.
Hierarchical nanostructuring approaches for thermoelectric materials with high power factors (2019)

The thermoelectric power factor of hierarchically nanostructured materials is investigated using the nonequilibrium Green's function method for quantum transport, including interactions of electrons with acoustic and optical phonons. We describe hierarchical nanostructuring by superlattice-like potential barriers/wells, combined with quantum dot barriers/wells nanoinclusions as well as voids in the intermediate region. We show that these structures can be designed in a way that the power factor is not only largely immune to the presence of the nanostructure features, but under certain conditions benefits can be achieved as well. Interestingly, we show that these design approaches are linked to the energy relaxation of the current flow and whether charge carrier scattering is limited by elastic or inelastic processes. In particular, when nanostructures form potential barriers, the power factor can be substantially enhanced under elastic scattering conditions, irrespective of nanostructuring density and potential barrier heights. When inelastic scattering processes dominate, however, the power factor is inevitably degraded. In the case in which nanostructures form potential wells, despite a slight decrease, the power factor is quite resilient under either elastic or inelastic scattering processes. These nanostructuring design approaches could help open the path to the optimization of new generation nanostructured thermoelectric materials by not only targeting reductions in thermal conductivity, but simultaneous improvements in the power factor as well.
A Simple and Efficient Image Pre-processing for QR Decoder (2012)

In order to lower the consumed threshold, a practical image preprocessing method was proposed for Quick Response (QR) barcode recognition. It could increase the speed of recognition by this decoder so as to embed this algorithm into mobile terminals. Instead of using the traditional methods such as edge detection and line detection, the encoding characteristic of QR had been used, thus the influence by background noise and geometric distortion was minimized. Moreover, it used alignment patterns to adaptively sample the barcode in terms of regions, which greatly improved the recognition rate. Experimental results demonstrate that the proposed approach can overcome the influence in noise, inhomogeneous light and geometric distortion, what is more, it meets the requirement of decoding in real time.
Double-Mode Stellar Pulsation (1993)

Abstract The current observational and theoretical status of the double-mode variables is reviewed. Focusing mostly on the RR Lyrae stars, we address the question of the observational evidence of modal stability . The problem of stationarity is a crucial issue in the modelling of these stars. We mention past efforts in hydrodynamical and analytical modelling together with a detailed discussion of some very recent results. It is suggested that stochastic forcing due to turbulent convection may play a crucial role in exciting some marginally stable modes in the limiting pulsation. The latest hydrodynamical results first demonstrate that purely radiative models are able to show permanent double-mode behavior in the relevant period regime of RRd stars. The reason for the previous lack of double-mode behavior is attributed to the large dissipation, i.e . artificial viscosity, generally used in the codes to ensure numerical stability and to obtain amplitudes comparable to the observed ones. We think that better models should include some physical dissipation, most probably turbulent convection, and a more accurate numerical treatment of the radiative hydrodynamics.
Dealing with shadows: Capturing intrinsic scene appearance for image-based outdoor localisation (2013)

In outdoor environments shadows are common. These typically strong visual features cause considerable change in the appearance of a place, and therefore confound vision-based localisation approaches. In this paper we describe how to convert a colour image of the scene to a greyscale invariant image where pixel values are a function of underlying material property not lighting. We summarise the theory of shadow invariant images and discuss the modelling and calibration issues which are important for non-ideal off-the-shelf colour cameras. We evaluate the technique with a commonly used robotic camera and an autonomous car operating in an outdoor environment, and show that it can outperform the use of ordinary greyscale images for the task of visual localisation.
Individual differences in decision making: Drive and Reward Responsiveness affect strategic bargaining in economic games. (2006)

These findings are consistent with an interpretation that high scores on Drive and Reward Responsiveness are associated with a strategy that first seeks to maximize the likelihood of reward, and then to maximize the amount of reward. More generally, these results suggest that there are additional factors other than empathy, fairness and selfishness that contribute to strategic decision-making.
Investigation of the TCP simultaneous-send problem in 802.11 wireless local area networks (2005)

This paper investigates the TCP simultaneous-send problem (SSP) which arises in infrastructure mode WLANs. In particular it has been observed that for file transfer traffic, 802.11 wireless nodes have a sustained supply of packets to send and hence experience a relatively high rate of MAC contention. For TCP, this results in competition among data and ACK packets for channel access which causes the SSP that deteriorates flow throughput. This SSP can be alleviated by skipping TCP ACKs. Detailed simulation results are presented to demonstrate the usefulness of ACK skipping in various network scenarios such as with MAC retries and multiple TCP flows. The largest improvement is seen for the case of a single TCP flow, and moderate gains are also achieved in cases with multiple streams. For the single TCP stream case with 1 ACK skip and no MAC retries, TCP throughput improves 30% for short-lived and 98% for long-lived TCP transmissions. The paper concludes with potential cross-layer solutions that potentially provide further improvements, including the use of the point coordination function (PCF) to reduce contention between multiple TCP streams and returning ACK packets.
Sympathetic nerve activity during natural stimulation of horizontal semicircular canals in humans (1998)

We have shown that static head-down neck flexion elicits increases in muscle (MSNA) but not skin sympathetic nerve activity (SSNA) in humans. These findings suggest that stimulation of the otolith organs causes differential sympathetic outflow to vascular beds. The purpose of the present study was to determine whether yaw head rotation (YHR), which stimulates the horizontal semicircular canals, elicits sympathetic nerve responses. To test this question, we recorded MSNA (n = 33) and SSNA (n = 25) before and during 3 min of sinusoidal YHR performed at 0.1, 0.6, and 1.0 Hz. At all frequencies, YHR elicited no significant changes in heart rate and mean arterial pressure. Likewise, YHR did not significantly change either MSNA or SSNA at all frequencies. Our results indicate that stimulation of the horizontal semicircular canals by YHR does not alter SNA to either muscle or skin. Moreover, these results provide evidence to support the concept that the otolith organs but not the horizontal semicircular canals participate in the regulation of SNA in humans.
The Ascorbate-glutathione-α-tocopherol Triad in Abiotic Stress Response (2012)

The life of any living organism can be defined as a hurdle due to different kind of stresses. As with all living organisms, plants are exposed to various abiotic stresses, such as drought, salinity, extreme temperatures and chemical toxicity. These primary stresses are often interconnected, and lead to the overproduction of reactive oxygen species (ROS) in plants, which are highly reactive and toxic and cause damage to proteins, lipids, carbohydrates and DNA, which ultimately results in oxidative stress. Stress-induced ROS accumulation is counteracted by enzymatic antioxidant systems and non-enzymatic low molecular weight metabolites, such as ascorbate, glutathione and α-tocopherol. The above mentioned low molecular weight antioxidants are also capable of chelating metal ions, reducing thus their catalytic activity to form ROS and also scavenge them. Hence, in plant cells, this triad of low molecular weight antioxidants (ascorbate, glutathione and α-tocopherol) form an important part of abiotic stress response. In this work we are presenting a review of abiotic stress responses connected to these antioxidants.
The Amyloid Beta Peptide: A Chemist’s Perspective. Role in Alzheimer’s and Fibrillization (2012)

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTThe Amyloid Beta Peptide: A Chemist's Perspective. Role in Alzheimer's and FibrillizationI. W. Hamley*View Author Information Department of Chemistry, University of Reading, Whiteknights, Reading RG6 6AD, U.K.*E-mail: [email protected]Cite this: Chem. Rev. 2012, 112, 10, 5147–5192Publication Date (Web):July 19, 2012Publication History Received8 March 2012Published online19 July 2012Published inissue 10 October 2012https://pubs.acs.org/doi/10.1021/cr3000994https://doi.org/10.1021/cr3000994review-articleACS PublicationsCopyright © 2012 American Chemical SocietyRequest reuse permissionsArticle Views19159Altmetric-Citations744LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Aggregation,Central nervous system,Nanofibers,Oligomers,Peptides and proteins Get e-Alerts
Computer Processing of Diagnostic Ultrasound Data (1974)

A system has been developed to improve the image quality of diagnostic ultrasound data obtained from conventional ultrasound scanners. Echoes are initially recorded on a wideband analog magnetic tape recorder and subsequently digitized through the use of a high speed analog-to-digital converter. Computer pro- cessing is then used to increase resolution and to enhance coherent energy echoes. The final display contains echo amplitude and struc- ture information as well as indicating echo position. Signal processing techniques used thus far include averaging, band-pass filtering, and inverse filtering. Coherent energy echoes are enhanced by averaging and by applying band-pass filters in the appropriate frequency region. Resolution of echoes is increased through inverse filtering, an opera- tion which increases the bandwidth of the data. Examples of pro- cessed data obtained from model targets and from structures in the heart and head indicate significant improvement can be obtained using these techniques.
RefGenes: identification of reliable and condition specific reference genes for RT-qPCR data normalization (2011)

We therefore propose the normalization of RT-qPCR data using reference genes that are specifically chosen for the conditions under study. RefGenes is a community tool developed for that purpose. Validation RT-qPCR experiments across several organisms showed that the candidates proposed by RefGenes generally outperformed commonly used reference genes. RefGenes is available within Genevestigator at http://www.genevestigator.com.
Meloxicam (2002)

Meloxicam (Mobic trade mark, Boehringer Ingelheim) is a relatively new oral non-steroidal anti-inflammatory drug (NSAID) approved for the treatment of osteoarthritis in the US. It has also been evaluated for the treatment of rheumatoid arthritis, ankylosing spondylitis and acute 'rheumatic' pain. Meloxicam has been shown to be COX-2 preferential, particularly at its lowest therapeutic dose, and is anti-inflammatory by inhibiting prostanoid synthesis in inflammatory cells. Since it is COX-2 preferential, it would be expected to have less gastrointestinal toxicity than non-selective NSAIDs. In clinical trials of meloxicam in osteoarthritis, it was found to be as effective as piroxicam, diclofenac and naproxen with less clinical gastrointestinal symptoms and less perforations, obstructions and bleeds by meta-analysis. Adverse events, including peripheral oedema and hypertension, occurred at a similar rate as with traditional NSAIDs.
Mutual information maximizing linear precoding for parallel layer MIMO detection (2011)

In this paper mutual information maximizing linear precoding for MIMO transmission using finite signal alphabets and a parallel layer MIMO detection scheme is derived. The derivation exploits that the mutual information of the parallel detection scheme can be expressed in terms of the mutual information associated with optimal maximum likelihood detection. Results show that the large performance gap between parallel layer detection and maximum likelihood detection in ill conditioned channels can be substantially alleviated by optimal precoding.
WNT10B/β‐catenin signalling induces HMGA2 and proliferation in metastatic triple‐negative breast cancer (2013)

Wnt/β-catenin signalling has been suggested to be active in basal-like breast cancer. However, in highly aggressive metastatic triple-negative breast cancers (TNBC) the role of β-catenin and the underlying mechanism(s) for the aggressiveness of TNBC remain unknown. We illustrate that WNT10B induces transcriptionally active β-catenin in human TNBC and predicts survival-outcome of patients with both TNBC and basal-like tumours. We provide evidence that transgenic murine Wnt10b-driven tumours are devoid of ERα, PR and HER2 expression and can model human TNBC. Importantly, HMGA2 is specifically expressed during early stages of embryonic mammogenesis and absent when WNT10B expression is lost, suggesting a developmentally conserved mode of action. Mechanistically, ChIP analysis uncovered that WNT10B activates canonical β-catenin signalling leading to up-regulation of HMGA2. Treatment of mouse and human triple-negative tumour cells with two Wnt/β-catenin pathway modulators or siRNA to HMGA2 decreases HMGA2 levels and proliferation. We demonstrate that WNT10B has epistatic activity on HMGA2, which is necessary and sufficient for proliferation of TNBC cells. Furthermore, HMGA2 expression predicts relapse-free-survival and metastasis in TNBC patients.
Retarded field calculation of electron energy loss in inhomogeneous dielectrics (2002)

The exact solution of Maxwell's equations in the presence of arbitrarily shaped dielectrics is expressed in terms of surface-integral equations evaluated at the interfaces. The electromagnetic field induced by the passage of an external electron is then calculated in terms of self-consistently obtained boundary charges and currents. This procedure is shown to be suitable for the simulation of electron energy loss spectra when the materials under consideration are described by local frequency-dependent response functions. The particular cases of translationally invariant interfaces and axially symmetric interfaces are discussed in detail. The versatility of this method is emphasized by examples of energy loss spectra for electrons passing near metallic and dielectric wedges, coupled cylinders, spheres, and tori, and other complex geometries, where retardation aspects and Cherenkov losses can sometimes be significant.