gebhart/patrepeval huggingface dataset:
Asmarines I, J, and K and Nosyberkol:  Four New Compounds from the Marine Sponge <i>Raspailia</i> sp. (2004)

Five asmarines, the known A and F and three new ones, I, J, and K, and four diterpenes, the known chelodane, barekoxide, and zaatirin and a new one, nosyberkol, were isolated from the Nosy Be Islands (Madagascar) sponge Raspailia sp. The structures of all these compounds were established on the basis of MS and NMR data. A biogenesis for the various Raspailia sp. diterpenes is suggested.
Molecular Mechanisms Behind the Chemopreventive Effects of Anthocyanidins (2004)

Anthocyanins are polyphenolic ring-based flavonoids, and are widespread in fruits and vegetables of red-blue color. Epidemiological investigations and animal experiments have indicated that anthocyanins may contribute to cancer chemoprevention. The studies on the mechanism have been done recently at molecular level. This review summarizes current molecular bases for anthocyanidins on several key steps involved in cancer chemoprevention: (i) inhibition of anthocyanidins in cell transformation through targeting mitogen-activated protein kinase (MAPK) pathway and activator protein 1 (AP-1) factor; (ii) suppression of anthocyanidins in inflammation and carcinogenesis through targeting nuclear factor kappa B (NF- $\kappa$ B) pathway and cyclooxygenase 2 (COX-2) gene; (iii) apoptotic induction of cancer cells by anthocyanidins through reactive oxygen species (ROS) / c-Jun NH(2)-terminal kinase (JNK)-mediated caspase activation. These data provide a first molecular view of anthocyanidins contributing to cancer chemoprevention.
A Novel Channel-Program-Erase Technique with Substrate Transient Hot Carrier Injection for SONOS Memory Application (2006)

A novel and uniform channel program and erase method is presented to replace the FN tunneling operation for SONOS cells in NAND architecture. The proposed operation utilizes substrate transient hot electron (STHE) injection and substrate transient hot hole (STHH) injection for programming and erasing, respectively. Gate bias polarity can control whether hot electrons or hot holes are injected into the nitride storage layer. More efficient program and erase operation is achieved compared to conventional Fowler-Nordheim (FN) tunneling method. The new method operates at lower programming voltage and shorter pulse, thus increases the programming throughput. Good cycling endurance and data retention are obtained for SONOS memory applications
A novel oHSV-1 targeting telomerase reverse transcriptase-positive cancer cells via tumor-specific promoters regulating the expression of ICP4 (2015)

Virotherapy is a promising strategy for cancer treatment. Using the human telomerase reverse transcriptase promoter, we developed a novel tumor-selective replication oncolytic HSV-1. Here we showed that oHSV1-hTERT virus was cytopathic in telomerase-positive cancer cell lines but not in telomerase-negative cell lines. In intra-venous injection in mice, oHSV1-hTERT was safer than its parental oHSV1-17+. In human blood cell transduction assays, both viruses transduced few blood cells and the transduction rate for oHSV1-hTERT was even less than that for its parental virus. In vivo, oHSV1-hTERT inhibited growth of tumors and prolong survival in telomerase-positive xenograft tumor models. Therefore, we concluded that this virus may be a safe and effective therapeutic agent for cancer treatment, warranting clinical trials in humans.
Exposure assessment of carbon nanotube manufacturing workplaces (2010)

Seven CNT (carbon nanotube) handling workplaces were investigated for exposure assessment. Personal sampling, area sampling, and real-time monitoring using an SMPS (scanning mobility particle sizer), dust monitor, and aethalometer were performed to characterize the mass exposure, particle size distribution, and particle number exposure. No workplace was found to exceed the current ACGIH (American Conference of Governmental Industrial Hygienists) TLVs (threshold limit values) and OELs (occupational exposure levels) set by the Korean Ministry of Labor for carbon black (3.5 mg/m(3)), PNOS (particles not otherwise specified; 3 mg/m(3)), and asbestos (0.1 fiber/cc). Nanoparticles and fine particles were most frequently released after opening the CVD (chemical vapor deposition) cover, followed by catalyst preparation. Other work processes that prompted nanoparticle release included spraying, CNT preparation, ultrasonic dispersion, wafer heating, and opening the water bath cover. All these operation processes could be effectively controlled with the implementation of exposure mitigation, such as engineering control, except at one workplace where only natural ventilation was used.
Towards Model-Driven Middleware Maintenance (2002)

Over the last decades, network-centric information management has tremendously changed the business processes of organizations in the private and public sector. The introduction of middleware technology and standards has played an instrumental role in this development by enabling integration of distributed heterogeneous information systems (IS). Modern (so-called third-generation) net-centric systems use middleware among various types of software components ranging from mainframe computers down to PDAs and cell phones. The maintenance and evolution of such middleware software is a key challenge because of rapidly evolving hardware and software platforms. In this paper, we outline a systematic process for engineering and maintaining middleware solutions for third generation systems; this process is based on the Model-Driven Architecture approach&amp;trade; of the Object Management Group.
An Ascent of Koroyanitu (1948)

Koroyanitu is the high point of the Mt.Evans Range, a high and narrow ridge rising from the grassland hills of northwestern Viti Levu.This largest island of the Fijian archipelago is physiographically separable into two parts by a central mountain axis dominated by the Rairaimatuku Plateau, an extensive forested area with an average elevation of perhaps 800-900 me- ters.The western half of Viti Levu and a strip along the north coast are relatively dry savanna and bush, locally known as the talasinga country.The eastern half is wet forested land, called by the natives the veikau.The line of demarcation between these two types of land is often well defined.The Mt.Evans Range lies entirely within the dry zone of Viti Levu, but in height it is third on the island, exceeded only by Tomanivi, near the north- ern edge of the Rairaimatuku Plateau, and Korombasambasanga, south of the plateau.Because of its altitude (1195 meters), the Mt.Evans Range receives a heavy rainfall on its upper slopes and is well forested above an approximate 700 meters.Isolated from the main forest of Viti Levu by many miles of low, broken, reed-covered talasinga, the forested upper slopes of the Mt.Evans Range offer a tempting goal to a botanist.This range was selected as my first objective during a recent botanical reconnaissance of Fiji in 1947-1948.lThe Mt.Evans Range had the further advantage, in the eyes of a botani- cal explorer, of being essentially unknown botanically,2 although it had been explored by some of the surveyors who in recent years.have provided the Lands and Survey Department, of Suva, with excellent detailed maps of the larger islands.As headquarters for my five-week reconnaissance of the Mt.Evans Range, the Fijian village of Nalotawa was selected.Nalotawa lies at the eastern base of the Mt.Evans Range and has an elevation of about 550 me- ters, being situated in a wooded valley in the grassland, but only a mile or two from the beginning of the forest on the slopes of the range.On a prearranged day about 15 Fijian "boys" from Nalotawa met me and my "head assistant," a capable young Fijian named Tanieli Rawangga, at a sugar- cane plantation in the valley of the Mba River, to which point we had brought our supplies by truck.The professional tropical plant collector cannot travel light; he must have a supply of collecting paper, blottingpaper driers, corrugated boards, presses, straps, stoves and kerosene for drying specimens, axes, machetes, sundry other tools, and staple food supplies for whatever period he plans to remain in "the bush."MY 15 carriers
Ferric Citrate Hydrate for the Treatment of Hyperphosphatemia in Nondialysis-Dependent CKD (2014)

In patients with nondialysis-dependent CKD, 12-week treatment with ferric citrate hydrate resulted in significant reductions in serum phosphate and fibroblast growth factor-23 while simultaneously increasing serum iron parameters.
IBM POWER6 reliability (2007)

This paper describes the state-of-the art reliability features of the IBM POWER6™ microprocessor. The POWER6 microprocessor includes a high degree of detection of soft and hard errors in both dataflow and control logic, as well as a feature—instruction retry recovery (IRR)—usually available only on mainframe systems. IRR provides full hardware error recovery of those registers that are defined by the instruction set architecture. This is accomplished by taking a checkpoint of the defined state for both of the core threads and recovering the machine state back to a known good point. To allow changing memory accessibility without using different page table entries, the POWER6 microprocessor implements virtual page class keys, a new architectural extension that enables the OS (operating system) to manage eight classes of memory with efficiently modifiable access authority for each class. With this feature, malfunctioning kernel extensions can be prevented from destroying OS data that may, in turn, bring an OS down.
Meningococcal Polysaccharide A <i>O</i> -Acetylation Levels Do Not Impact the Immunogenicity of the Quadrivalent Meningococcal Tetanus Toxoid Conjugate Vaccine: Results from a Randomized, Controlled Phase III Study of Healthy Adults Aged 18 to 25 Years (2013)

In this study, we compared the immunogenicities of two lots of meningococcal ACWY-tetanus toxoid conjugate vaccine (MenACWY-TT) that differed in serogroup A polysaccharide (PS) O-acetylation levels and evaluated their immunogenicities and safety in comparison to a licensed ACWY polysaccharide vaccine (Men-PS). In this phase III, partially blinded, controlled study, 1,170 healthy subjects aged 18 to 25 years were randomized (1:1:1) to receive one dose of MenACWY-TT lot A (ACWY-A) (68% O-acetylation), MenACWY-TT lot B (ACWY-B) (92% O-acetylation), or Men-PS (82% O-acetylation). Immunogenicity was evaluated in terms of serum bactericidal activity using rabbit complement (i.e., rabbit serum bactericidal activity [rSBA]). Solicited symptoms, unsolicited adverse events (AEs), and serious AEs (SAEs) were recorded. The immunogenicities, in terms of rSBA geometric mean titers, were comparable for both lots of MenACWY-TT. The vaccine response rates across the serogroups were 79.1 to 97.0% in the two ACWY groups and 73.7 to 94.1% in the Men-PS group. All subjects achieved rSBA titers of ≥1:8 for all serogroups. All subjects in the two ACWY groups and 99.5 to 100% in the Men-PS group achieved rSBA titers of ≥1:128. Pain was the most common solicited local symptom and was reported more frequently in the ACWY group (53.9 to 54.7%) than in the Men-PS group (36.8%). The most common solicited general symptoms were fatigue and headache, which were reported by 28.6 to 30.3% and 26.9 to 31.0% of subjects, respectively. Two subjects reported SAEs; one SAE was considered to be related to vaccination (blighted ovum; ACWY-B group). The level of serogroup A PS O-acetylation did not affect vaccine immunogenicity. MenACWY-TT (lot A) was not inferior to Men-PS in terms of vaccine response and was well tolerated.
[Regression of an adenocarcinoma of the breast treated by progesteroid agents. Anatomical-clinical study]. (1976)

A 61-year old woman with breast adenocarcinoma was treated with hormonotherapy for 1 year. After this treatment the tumor had regressed and a mastectomy was performed. The macroscopic and histological examinations of the tumor showed similarities between the changes observed in this case and the ones which have been described by Emerson and his colleagues following estrogenotherapy and androgenotherapy in the case of clinically hormone-dependent breast cancers.
Sulfosulfuron Efficacy Is Affected by Surfactants, pH of Spray Mixture, and Salts (2001)

Sulfosulfuron {1-(4,6-dimethoxypyrimidin-2-yl)-3-[(2-ethanesulfonyl-imidazo[1,2-a]pyridine-3-yl)]sulfonylurea} must be applied with an adjuvant for effective postemergent weed control. Experiments were conducted to determine sulfosulfuron phytotoxicity to green foxtail (Setaria viridis L.) as influenced by surfactant chemistry, surfactant hydrophilic/lipophilic balance (HLB), spray mixture pH, and common nitrogen fertilizers. Regardless of accompanying surfactant chemistry, surfactant HLB, and nitrogen fertilizers, sulfosulfuron efficacy to green foxtail was greatly enhanced when applied in alkaline spray mixture (pH 7.4–8.2) compared to pH 4.0–5.7 unbuffered spray mixture. Secondary alcohol ethoxylate surfactants increased sulfosulfuron efficacy as HLB of these surfactants increased from 8.3 to 17.4 in unbuffered and buffered spray mixtures. The optimum HLB of various block copolymer surfactants for sulfosulfuron was from 9.0 to 13.0. In unbuffered spray mixture, ammonium nitrate at 0.25% w/v had no effect or antagonized sulfosulfuron phytotoxicity, especially when applied with block copolymer surfactants. However, urea fertilizer at 0.25% w/v enhanced herbicide efficacy, regardless of surfactants. Commercial 28% N liquid fertilizer (urea/ammonium nitrate solution) also increased sulfosulfuron efficacy with most surfactants, especially in unbuffered spray mixtures. In spray mixtures buffered above pH 7, the effects of surfactant HLB and nitrogen fertilizers on sulfosulfuron efficacy were less evident. Spray droplet spread and droplet drying time did not relate to sulfosulfuron efficacy. These data demonstrate a potential for optimizing sulfosulfuron efficacy by carefully selecting surfactant chemistry, surfactant HLB, addition of proper nitrogen fertilizer, and by regulating the pH of the spray mixture.
Characterization methods for metamaterials : directive antennas using space eigen-mades (2014)

The work presented in this thesis concerns two parts: characterisation methods for metamaterials and directive antennas using space eigen-modes. The first one describes the homogenisation methods of metamaterials to retrieve the constitutive parameters from scattering parameters of the metamaterial's slab. We investigated the metamaterials which present the most common properties of media: bi-isotropic metamaterials (chiral), anisotropic metamaterials (BC-SRR), uni-axial bi-anisotropic metamaterials (double omega medium) and bi-axial bi-anisotropic metamaterials (EC-SRR). The transverse and longitudinal constitutive parameters characterising the anisotropic and bi-anisotropic require to examine the media at normal and oblique incidences. In the analysis we considered to distinguish continuous media restricted to long wave limit and resonating particles lattice which are out of long wave limit. The application of continuous media approach to the resonating particle lattice with size not satisfying the long wave limit can leads to violation of causality and passivity laws. The main different between proposed two approaches is interpretation of boundary conditions (Maxwellian/non-Maxwellian) for the metamaterial slab. The inclusions of lattice we ascribe as electric and magnetic dipole moments to develop an homogeneous resonating particles lattice and to retrieve the constitutive parameters. We validated the proposed approaches and compared the retrieved constitutive parameters according to physical laws. We found that the application of Bloch admittance and equivalence to electric and magnetic dipole moments provides the physical constitutive parameters. The second part of the thesis refers to directive antenna using space eigen-modes. The directivity of the antennas is limited to the size of the antenna or number of elements in an array. In common with keeping small sizes of the array the space between radiation elements has to be minimised. The proposed directive antenna considers the radiation elements determine by the orthogonal modes, i.e. each radiator of the array corresponds to unique space eigen-mode. This allows to ensure small distance between the array elements without introduction of high mutual coupling between them. The original approach refers to superposition of spherical modes however it is not practical. Instead of spherical modes we propose superposition of cylindrical modes which are easy to be realised. For the constructive summation of cylindrical modes and maximisation of directivity in end-fire plane we determine amplitudes of the cylindrical modes excited by electric and/or magnetic vector potentials. The cylindrical modes we obtain by the annular ring antennas and miniaturised annular rings. The superposition of cylindrical modes is achieved with a stacked antenna of annular rings and a coplanar cylindrical annular rings antenna. The both antennas we realised and measured.
Isolation of Plasma Cholesterol-Lowering Components from Ningyotake (Polyporus confluens) Mushroom. (1992)

The present study was undertaken to isolate component(s) which contributes to the hypocholesterolemic action of Ningyotake (Polyporus confluens) mushroom. The mushroom powder was extracted with 80% ethanol, and the extract and residue were fractionated into five fractions according to the solubility to solvents. When each fraction was added to a diet containing 1% cholesterol and 0.25% sodium cholate and fed to rats, the plasma cholesterol level was significantly decreased only by ethyl acetate-soluble fraction. Therefore, ethyl acetate-soluble fraction was further fractionated by silica gel column chromatography. Two major compounds, which comprised 45.0% and 28.5% of the ethyl acetate-soluble fraction, were obtained in a pure form by the chromatography, and the compounds were identified as grifolin (2-trans, trans-farnesyl-5-methylresorcinol) and neogrifolin (4-trans, trans-farnesyl-5-methylresorcinol), respectively. The addition of grifolin and neogrifolin to the high cholesterol diet was found to lower plasma cholesterol level significantly.
Identification of HN-1-Peptide Target in Head and Neck Squamous Cell Carcinoma Cells (2011)

The HN-1 module was previously reported to ensure efficient targeting of head and neck squamous cell carcinoma (HNSCC). Aim of this work was to indentify the target of HN-1. Targeting of HN-1 peptide was compared in normal epithelial cells (BEAS-2B) and in HNSCC tumor cells (SCC-25 and Detroit 562). Experimental, cell culture, cell polarity, and adhesion conditions were tested; structure models of peptides were created. Indeed, HN-1 was able to target HNSCC tumor cells in the previously published conditions. The targeting efficiency of immortalized normal epithelial cells was significantly lower. Nevertheless, in other experimental conditions the binding was less efficient and not specific. A scrambled sequence of HN-1, with altered order of amino acids showed even better targeting efficiency than HN-1. HN-1 was only uptaken in adherent cells, not in suspension. In conclusion, HN-1-peptide-targeting is not based on sequence specificity, but more on electrostatic interactions with the cell surface of the tumor cells.
SSRIs vs. TCAs in the treatment of panic disorder: a meta‐analysis (2002)

SSRIs and TCAs are equal in efficacy in the treatment of panic disorder, but SSRIs are tolerated better.
Liquid Crystals in Cylindrical Pores: Effects on Transition Temperatures and Singularities (1983)

Abstract Positive dielectric anisotropy liquid crystals are studied in cylindrical pores in a 10 μm thick polymer membrane of diameters 0.2-12μm. Transition temperature depressions increase with decreasing pore size. Singularities of strength 1 are observed in the center of the pores, accompanied by some strength ½ singularities. By applying a voltage across the membrane, the S = 1 singularities are shown to be “escaped” singularities. S = +½ singularities show a critical destruction at a characteristic voltage.
Dairy products: California's manufactured products in relation to those of other areas (1949)

California Agriculture - All Issues
Viscometer for Dextrin Pastes (1952)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTViscometer for Dextrin PastesW. R. Fetzer, E. K. Crosby, and R. E. FullickCite this: Anal. Chem. 1952, 24, 10, 1671–1672Publication Date (Print):October 1, 1952Publication History Published online1 May 2002Published inissue 1 October 1952https://pubs.acs.org/doi/10.1021/ac60070a058https://doi.org/10.1021/ac60070a058research-articleACS PublicationsRequest reuse permissionsArticle Views30Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Outline of an algorithm for integer solutions to linear programs (1958)

The purpose of this department is to provide early announcement of significant new results, with some indications of proof. Although
Temporal and Spatial Expression of Amygdalin Hydrolase and (R)-(+)-Mandelonitrile Lyase in Black Cherry Seeds (1995)

In black cherry (Prunus serotina Ehrh.) macerates, the cyanogenic diglucoside (R)-amygdalin undergoes stepwise degradation to HCN catalyzed by amygdalin hydrolase (AH), prunasin hydrolase, and (R)-(+)-mandelonitrile lyase (MDL). A near full-length AH cDNA clone (pAH1), whose insert encodes the isozyme AH I, has been isolated and sequenced. AH I exhibits several features characteristic of beta-glucosidases of the BGA family, including their likely nucleophile center (isoleucine-threonine-glutamic acid-asparagine-glycine) and acid catalyst (asparagine-glutamic acid-proline/isoleucine) motifs. The temporal expression of AH and MDL in ripening fruit was analyzed by northern blotting. Neither mRNA was detectable until approximately 40 days after flowering (DAF), when embryos first became visible to the naked eye. Both mRNAs peaked at approximately 49 DAF before declining to negligible levels when the fruit matured (82 DAF). Taken together with enzyme activity data, these time courses suggest that AH and MDL expression may be under transcriptional control during fruit maturation. In situ hybridization analysis indicated that AH transcripts are restricted to the procambium, whereas MDL transcripts are localized within cotyledonary parenchyma cells. These tissue-specific distributions are consistent with the major locations of AH and MDL protein in mature seeds previously determined by immunocytochemistry (E. Swain, C.P. Li, and J.E. Poulton [1992] Plant Physiol 100:291-300).