gebhart/patrepeval huggingface dataset:
Hemodialysis in Chronic Schizophrenic Patients (1978)

Ten schizophrenic patients were dialyzed once a week for 16 weeks. They showed marked abnormalities in thinking, affect, and behavior. When out of the hospital, they lived vegetative, nonproductive lives. Seven patients at the end of the 16-week period showed no or minimal symptoms involving thinking, affect, and behavior. One patient showed moderate improvement, and there were two treatment failures.
Structural studies on the degradation products of vincristine dihydrogen sulfate. (1985)

Vincristine was incubated at 37 degrees C for 72 h in 0.2 M glycine buffer (pH 7.4 or 8.8) containing 1% bovine serum albumin. The reaction mixture was extracted with CH2Cl2. High-performance liquid chromatography analysis (muBondapak C18 reverse-phase 10-micron steel column; solvent, 50% MeOH in 10 mM KH2PO4, pH 4.5; flow rate, 1.2 ml/min) of the CH2Cl2 extract gave 6 peaks, A, B, C, D, E, and F, with retention times of 4.8, 6.5, 10.0, 12.5, 17.5, and 23.5 min, respectively. Peak C corresponded with vincristine. Spectroscopic data for these peak fractions were as follows [UV (lambda max); infrared (cm-1); mass spectrum (m/z)]: peak A: 220, 256, and 295 nm; 3457, 2922, 1730, and 1669; and 783 (MH+); peak B: 218, 255, and 296 nm; 3435, 2922, 1731, and 1673; and 783 (MH+); peak C: 220, 255, and 296 nm; 3457, 2922, 1738, and 1680; and 825 (MH+); peak D: 218, 252, and 296 nm; 3385, 2922, 1734, and 1677; and 825 (MH+); peak E: 208, 218, 252, and 298 nm; 3371, 2922, 1727, and 1665; and 768 (MH2+); and peak F: 209, 222, 255, and 296 nm; 3392, 2922, 1734, and 1673; and 823 (MH+). These data suggest the following tentative structures for the degradation products: peak A, 4-deacetylvincristine; peak B, an isomer of 4-deacetylvincristine; peak D, an isomer of vincristine; peak E, 4-deacetyl-3-deoxyvincristine; and peak F, N-formylleurosine. The structure of peak A as 4-deacetylvincristine was confirmed by chemical synthesis.
High injection in epitaxial transistors (1969)

An analysis of base widening and the current dependence of the cutoff frequency f <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</inf> has been given previously [1]. The analysis is approximate and is based on the location of the edges of transition regions. Definition of transition regions becomes problematic in transistors having nonuniform base doping and for high-current densities. Such difficulties are avoided in this paper by use of the charge control approach. Numerical solutions of delay time ( <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">= 1/2\pi f_{T}</tex> ) as a function of current density are given for low reverse collector bias. Whereas transition regions can be defined only approximately, the electric field is a well-defined quantity, and changes in the electric field that accompany base widening are shown in detail. At low injection levels, a high-field region exists near the transition between base and epitaxial layer. This high-field region is relocated to the interface between epitaxial layer and substrate under high injection conditions. When this "high-field relocation" has occurred, the epitaxial layer acts as an extension of the base with an attendant increase in the delay time [1].
Methods for improved protein expression using pET vectors (1992)

Journal Article Methods for improved protein expression using pET vectors Get access Judy Furlong, Judy Furlong MRC Virology Unit and Virology Department, Glasgow UniversityChurch Street, Glasgow G11 5JR, UK + Present address: Department of Biological Sciences, University of Durham, Science Laboratories South Road, Durham DH1 3LE, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar Michelle Meighan, Michelle Meighan MRC Virology Unit and Virology Department, Glasgow UniversityChurch Street, Glasgow G11 5JR, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar Joe Conner, Joe Conner MRC Virology Unit and Virology Department, Glasgow UniversityChurch Street, Glasgow G11 5JR, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar Jill Murray, Jill Murray MRC Virology Unit and Virology Department, Glasgow UniversityChurch Street, Glasgow G11 5JR, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar J.Barklie Clements J.Barklie Clements * MRC Virology Unit and Virology Department, Glasgow UniversityChurch Street, Glasgow G11 5JR, UK * To whom correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 20, Issue 17, 11 September 1992, Page 4668, https://doi.org/10.1093/nar/20.17.4668 Published: 11 September 1992 Article history Received: 26 June 1992 Published: 11 September 1992
Chemical Modification of Cellulose with Succinic Anhydride in Ionic Liquid with or without Catalysts (2011)

Chemical Modification of Cellulose with Succinic Anhydride in Ionic Liquid with or without Catalysts
Hospitals can boost profits by going according to plan. (1991)

Hospitals that conduct strategic planning and implement comprehensive business plans are more profitable and efficient than hospitals without written plans, a new study shows. It also found that most successful hospitals included strategies to measure and improve quality and customer services in their business plans. Of the administrators that didn't conduct strategic planning, most said they hoped to begin in the next year.
Fruit-Surface Flavonoid Accumulation in Tomato Is Controlled by a SlMYB12-Regulated Transcriptional Network (2009)

The cuticle covering plants' aerial surfaces is a unique structure that plays a key role in organ development and protection against diverse stress conditions. A detailed analysis of the tomato colorless-peel y mutant was carried out in the framework of studying the outer surface of reproductive organs. The y mutant peel lacks the yellow flavonoid pigment naringenin chalcone, which has been suggested to influence the characteristics and function of the cuticular layer. Large-scale metabolic and transcript profiling revealed broad effects on both primary and secondary metabolism, related mostly to the biosynthesis of phenylpropanoids, particularly flavonoids. These were not restricted to the fruit or to a specific stage of its development and indicated that the y mutant phenotype is due to a mutation in a regulatory gene. Indeed, expression analyses specified three R2R3-MYB-type transcription factors that were significantly down-regulated in the y mutant fruit peel. One of these, SlMYB12, was mapped to the genomic region on tomato chromosome 1 previously shown to harbor the y mutation. Identification of an additional mutant allele that co-segregates with the colorless-peel trait, specific down-regulation of SlMYB12 and rescue of the y phenotype by overexpression of SlMYB12 on the mutant background, confirmed that a lesion in this regulator underlies the y phenotype. Hence, this work provides novel insight to the study of fleshy fruit cuticular structure and paves the way for the elucidation of the regulatory network that controls flavonoid accumulation in tomato fruit cuticle.
Quantifying the impact of proximity error correction on plasmonic metasurfaces [Invited] (2015)

Plasmonic metasurfaces are often limited in their application by poor device performance, which is caused - in part - by deviations between fabricated devices and the ideal design. We show in this letter that these deviations are reduced significantly by shape-correction, intra-structure proximity error correction. We show experimentally that the fabrication fidelity alone is not a good indicator of the device quality and that direct measurements of the optical performance are necessary. Our fabrication improvements result in increased optical performance, reaching a measurement fidelity as high as 90%.
VIOLIN AND HARPSICHORD (1963)

VIOLIN AND HARPSICHORD Get access G.B. Fontana, Six Sonatas, ed. by Friedrich Cerha. 3 books. ( Doblinger, Vienna & Munich; Universal Edition, London, 1962, 12s. 6d. each.) E. R. E. R. Search for other works by this author on: Oxford Academic Google Scholar Music and Letters, Volume 44, Issue 3, July 1963, Pages 313-a–313, https://doi.org/10.1093/ml/44.3.313-a Published: 01 July 1963
OWL Web Ontology Language - Reference (2004)

The {W}eb {O}ntology {L}anguage {OWL} is a semantic markup language for publishing and sharing ontologies on the {W}orld {W}ide {W}eb. {OWL} is developed as a vocabulary extension of {RDF} (the {R}esource {D}escription {F}ramework) and is derived from the {DAML}+{OIL} {W}eb {O}ntology {L}anguage. {T}his document contains a structured informal description of the full set of {OWL} language constructs and is meant to serve as a reference for {OWL} users who want to construct {OWL} ontologies.
Effects of aclidinium bromide on exercise endurance, dynamic hyperinflation, physical activity and exertional dyspnoea in patients with moderate to severe COPD (2013)

INTRODUCTION: Lung hyperinflation is related to exertional dyspnoea, exercise intolerance and reduced physical activity in COPD patients. AIMS: To investigate the effects of aclidinium on dynamic hyperinflation, exercise endurance time, physical activity and dyspnoea in COPD patients . METHODS: This double-blind, randomized, crossover study compared aclidinium bromide 400 µg BID (metered dose; equivalent to aclidinium 322 µg delivered dose) with placebo, each for 3 weeks, in 112 patients with moderate to severe stable COPD (FEV 1 1.50 L, 56.7% pred). Patients performed constant load exercise at 75% of peak incremental exercise work rate. The primary endpoint was change from baseline in endurance time at Week 3. Other assessments were dyspnoea (Borg scale), dynamic inspiratory capacity (dIC) and parameters of physical activity (SenseWear® accelerometer). RESULTS: see table Change from baseline Aclidinium 400 µg BID Placebo Δ Adjusted LS mean (95% CI), Week 3 Endurance time, s 68.3 (31.1, 105.6) 9.8 (-27.8, 47.4) 58.5* (9.0, 108.0) Dyspnoea, units -0.48 (-0.87, -0.09) 0.15 (-0.25, 0.54) -0.63* (-1.11, -0.14) dIC, mL At rest 140 (78, 202) -36 (-98, 26) 176‡ (92, 260) Isotime 117 (58, 0.176) -38 (-97, 21) 155† (76, 234) Peak 119 (62, 175) -42 (-98, 14) 161‡ (87, 235) Mean over 1 week Daily physical activity Active energy consumption, kcal 22 -33 55* Step count, steps 296 -163 459 Moderate activity, mins 4.2 -5.9 10.0* p<0.05, †p<0.001, ‡p<0.0001 CONCLUSIONS: Aclidinium significantly improved dynamic hyperinflation, exercise tolerance, physical activity and dyspnoea compared with placebo in COPD patients.
High-level desmin expression depends on a muscle-specific enhancer (1990)

Expression of the desmin gene is increased several-fold during myogenesis. To identify the DNA sequences involved in this regulation, a 16-kilobase fragment containing a 4.5-kilobase 5‘-flanking region and the complete sequence of the human desmin gene has been isolated. The transcription initiation sites were determined by S1 nuclease mapping and primer extension analysis. A series of constructs have been made by fusing different lengths of human desmin 5‘-flanking fragments to the bacterial chloramphenicol acetyl transferase (CAT) gene, these constructs were introduced either into mouse myogenic cells or into nonmyogenic cells. Comparison of the transient expression of CAT between myogenic and nonmyogenic cells demonstrated that the sequence including 228 base pairs upstream of the transcription initiation site is sufficient to confer low level, muscle-specific expression of the desmin gene. A negative region was located between -693 and -228 base pairs relative to the desmin mRNA start site. High level expression of the gene depends on a 280-base pair muscle-specific enhancer located between -693 and -973 base pairs upstream of the transcription initiation site. This enhancer can activate either the desmin promoter or heterologous promoters about 20-70-fold in myogenic cells. The enhancer, which also acts in myoblast, is discussed in the context of early expression of the desmin during skeletal myogenesis in the mammalian embryo.
Studies on Catabolism of <sup>125</sup>I-Labelled Fibrinogen in Normal Rabbits and in Rabbits with Indwelling Intravenous Catheters: Methodologic Aspects (1975)

The catabolism of rabbit fibrinogen labelled with radioactive iodine was studied over a period of 7-9 days in normal rabbits and in rabbits with indwelling intravenous catheters. The labelled fibrinogen was highly clottable and homogeneous on immunoelectrophoresis and disc electrophoresis. The protein-bound 125I-activity amounted to at least 99%. Normal rabbits with a weight between 1.6 and 2.2 kg exhibited a mean plasma volume of 41.65 ml/kg. A mean half-life time of 1.69 days and a mean fractional catabolic rate of 59.8% of the plasma fibrinogen pool per day was computed by tracing labelled fibrinogen. The absolute catabolic rate revealed a mean value of 58.7 mg/kg body weight/day. Comparable results were obtained for all three labelled fibrinogen batches. A siliconized polyvinyl tubing with an outer diameter of 2.0 mm inserted into a jugular vein up to a length of 10-12 cm and indwelling for more than 10 days did not significantly influence the parameters studied for controlling the fibrinogen catabolism except for the absolute catabolic rate of 112.8 mg/kg/day which differed significantly from that of the control group. Thus, the indwelling intravenous catheter had no or only a minor effect on the activation of intravascular coagulation.
Preparation of trace element reference materials by a co-precipitated gel technique (1978)

A method is described for the preparation of trace element reference materials by a co-precipitated gel technique. The technique is applied to the manufacture of multi-element calibration standards for the analysis of geological materials by direct-reading emission spectrometry. The quality of gel reference material is considered in terms of homogeneity, major element and trace element accuracy and purity. Results are presented for the analysis of the gels by a variety of techniques, and for the analysis of international standard geological materials by direct-reading emission spectrometry with gel reference materials calibration.
Mario Rizo, Identidad y derechos: los Titulos Reales del Pueblo de Sutiaba. Instituto de Historia de Nicaragua y Centroamérica, Managua, 1999, 291 p. (2000)

Peut-etre, un jour, sur la plaza mayor de Sutiaba, aujourd’hui faubourg de Leon, ville du nord-ouest du Nicaragua, verra-t-on une statue de Dona Ernestina Roque ? A sa facon, ce livre est deja un hommage a cette femme indienne, qui pendant la plus grande partie de ce siecle conserva precieusement un ensemble de documents, titres de propriete et arche de memoire de la communaute sutiaba. Il s’agit, au depart, de copies de documents agraires – certains remontent au debut du XVIIe siecle-, faite...
Power-safe test application using an effective gating approach considering current limits (2011)

Freezing scan cell outputs can block transitions to the combinational components thus reduce shift power. The extra logic introduces area overhead, reduces timing margin and increases power in capture mode. This paper proposes a partial gating flow that calculates instance toggling probability to identify power sensitive cells. The toggling rate reduction tendency is demonstrated to be useful in estimating how much extra logic is needed to achieve a desired shift power reduction rate for a design. To ensure power safety across entire test session, the toggling rate metric is enhanced to consider the effect of capture power increase. A complementary pair of weights can adjust the power change in shift and capture modes, thus achieve an overall balanced power safety. The toggling probability metric along with the proposed flow provide a flexibility that benefits various practical power requirements when considering current limits of both circuit and tester.
Fault Phase Selector by Fault Component of Compensation Voltage Based on Traveling Wave (2006)

A novel fault phase selector by fault component of compensation voltage based on traveling wave is presented for high-speed protection. The compensation voltage is calculated from directional traveling waves by traveling wave transmitting formula on distributed parameters of transmission line. This compensation voltage is used in the fault phase selector. Sampling data of voltages and currents are used directly, hence it has high speed and is suitable for high-speed protection. The principle and algorithm are presented and EMTP simulation proves their correction.
Rapid reconstruction of small objects on mobile phones (2011)

Augmented Reality (AR) on mobile phones is receiving more and more attention recently, becoming a popular research topic and an important commercial field. In this paper we present a lightweight method to create coarse 3D models of small-scale objects. The goal is to give the users the possibility to create and maintain AR content themselves without the need for expensive tools and complex interaction. Our algorithm is based on shape-from-silhouette using voxel carving and runs on modern smartphone hardware. 3D models of certain object groups can be generated interactively and instantly. The actual result is visualized continuously using image based rendering methods to inform the user about the actual model quality. Given a suitably accurate model it can further be used for any means of AR and can easily be shared with other users. The usability of our approach is evaluated using modern smartphone hardware (see Figure 1). The advantages are demonstrated using a set of models for playing a board game.
Adipose Deficiency of <i>Nrf2</i> in <i>ob/ob</i> Mice Results in Severe Metabolic Syndrome (2012)

Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that functions as a master regulator of the cellular adaptive response to oxidative stress. Our previous studies showed that Nrf2 plays a critical role in adipogenesis by regulating expression of CCAAT/enhancer-binding protein β and peroxisome proliferator-activated receptor γ. To determine the role of Nrf2 in the development of obesity and associated metabolic disorders, the incidence of metabolic syndrome was assessed in whole-body or adipocyte-specific Nrf2-knockout mice on a leptin-deficient ob/ob background, a model with an extremely positive energy balance. On the ob/ob background, ablation of Nrf2, globally or specifically in adipocytes, led to reduced white adipose tissue (WAT) mass, but resulted in an even more severe metabolic syndrome with aggravated insulin resistance, hyperglycemia, and hypertriglyceridemia. Compared with wild-type mice, WAT of ob/ob mice expressed substantially higher levels of many genes related to antioxidant response, inflammation, adipogenesis, lipogenesis, glucose uptake, and lipid transport. Absence of Nrf2 in WAT resulted in reduced expression of most of these factors at mRNA or protein levels. Our findings support a novel role for Nrf2 in regulating adipose development and function, by which Nrf2 controls the capacity of WAT expansion and insulin sensitivity and maintains glucose and lipid homeostasis.
Monoclonal antibody Br4 recognizes specific neuronal celltypes (1991)

A monoclonal antibody termed as Br4 was prepared by a fusion of the myeloma P3 x 63-AG8-653 with spleen cells from BALB/c mice immunized with chick embryonic brain cells. Immunocytochemically, it reacts strongly with certain neurons in cerebral cortex, hippocampus, substantia nigra, and granular layer of cerebellum from rat brain but does not react with the white matter. A monoclonal antibody Br4 also reacts with primary cultured chick neurons, but not with cultured astrocytes. Western blots show that Br4 recognizes three proteins of 145,000, 108,000, and 97,000 molecular weight from the rat brain. The protein with molecular weight 145,000 (p145) and the protein with 97,000 molecular weight (p97) are essentially soluble; p145 is especially enriched in the synaptosomal soluble fraction. The protein with 108,000 molecular weight (p108) is found in both membrane-bound and soluble forms. Western blots show that among the tissues examined the three proteins are found most abundant in brain and especially enriched in the cerebral cortex and hippocampus. The Br4 antigens may be useful in identifying neuronal cell subpopulations in the central nervous system.
Spectrophotometric Determination of Phosphorus (1942)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSpectrophotometric Determination of PhosphorusT FontaineCite this: Ind. Eng. Chem. Anal. Ed. 1942, 14, 1, 77–78Publication Date (Print):January 1, 1942Publication History Published online1 May 2002Published inissue 1 January 1942https://pubs.acs.org/doi/10.1021/i560101a038https://doi.org/10.1021/i560101a038research-articleACS PublicationsRequest reuse permissionsArticle Views440Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
[Experimental study of Chinese Agkistrodon acutus venom in activation of rabbit platelets in vivo]. (1994)

Fourteen Albino rabbits, male and female, were allocated randomly into two groups: control group which had intravenous infusion of normal saline, and experimental group which had intravenous infusion of Chinese Agkistrodon Acutus venom (CAAV) 0.075 mg/kg. Platelet was reduced, plasma PF4 activity and 5-HT concentration increased, 5-HT content in platelets was reduced in the experimental group 10, 20, and 50 minutes after the infusion. It had a significant difference (P < 0.01), compared with that in the control group. Platelets were aggregated into masses under electron microscope 10 minutes after the infusion of CAAV. The study has proved that blood platelets in rabbits are activated by Chinese Agkistrodon Acutus venom.
Cancer Prevention: Strong Science and Real Medicine (2005)

Many of us working in cancer prevention over the past two decades have begun our primary papers with something resembling the following remarks: ‘‘It is estimated that x cancer will account for y new cancer diagnoses and z deaths in the United States alone this year. These grim statistics persist despite advances in cancer therapy, arguing forcibly for a new approach, such as in cancer prevention, to help in controlling this devastating disease.’’ Alas, this general rationale for cancer prevention is still relevant. In 2004, it is estimated that cancers of the breast, prostate, bladder, colon/rectum, lung/bronchus, and oral cavity/pharynx will account for 856,760 new cancer diag