gebhart/patrepeval huggingface dataset:
Regulation of Macrophage Inflammatory Protein-1α mRNA by Oxidative Stress (1996)

Accumulation of inflammatory cells within the lung has been implicated in oxidative injury. Recruitment of these cells to a tissue site is a complex process that depends in part upon the local expression of appropriate proinflammatory chemokines. Macrophage inflammatory protein-1alpha (MIP-1alpha), a member of the CC subfamily of chemokines, has been shown to contribute to monocyte/macrophage and neutrophil chemotaxis and activation. Our previous work demonstrated that MIP-1alpha mRNA expression in macrophages is induced by bacterial endotoxin. The objective of this study was to test the hypothesis that an oxidative stress alone may trigger expression of MIP-1alpha mRNA in macrophages and to determine the mechanism leading to increased expression. A rat alveolar macrophage cell line (NR8383) was exposed to H2O2 or menadione (2-methyl-1,4-naphthoquinone (MQ)), a quinone compound that undergoes redox cycling and generates reactive oxygen species continuously. Steady-state mRNA levels encoding MIP-1alpha were markedly increased (3-fold) in these cells after 1 h of exposure to 0.5 mM H2O2, remained higher than control levels after 4 h, and decreased after 6 h. Similarly, MQ (25 or 50 microM) caused a significant increase of MIP-1 alpha mRNA with a maximal induction after 4 h of exposure (5-fold). Both H2O2 and MQ-induced up-regulation of MIP-1 alpha mRNA was suppressed by co-treatment with N-acetylcysteine, a synthetic antioxidant. Co-treatment with actinomycin D reduced the MQ induction of MIP-1alpha mRNA to a greater extent than the H2O2-induced increase. Transcription of the MIP-1alpha gene was increased by exposure to both H2O2 and MQ. H2O2 treatment also induced a marked increase of the MIP-1alpha mRNA half-life, indicating post-transcriptional stabilization. These observations indicate that an oxidative stress can regulate MIP-1alpha mRNA expression by two distinct mechanisms: transcriptional activation of the MIP-1alpha gene and post-transcriptional stabilization of MIP-1alpha mRNA.
Integrated Cluster Bus performance for the IBM S/390 Parallel Sysplex (1999)

As the speed of the S/390® processors has increased at a rapid rate over the years, it has become extremely challenging to be able to connect them in a Parallel Sysplex® without compromising system performance. The cost of synchronous accesses to the coupling facility will build up progressively unless coupling link technology keeps pace with the development of the processors. Beginning with the G5 processors, IBM has introduced the ICB coupling link technology to enhance the performance of closely integrated processor clusters. With a high data transmission rate complemented by reduced hardware and microcode path lengths, the ICB provides excellent coupling efficiency. This paper emphasizes the need for the ICB and discusses the superior performance delivered by this latest coupling link technology.
Epidemiologia da leishmaniose visceral humana em Fortaleza-CE (2012)

Objetivo: Analisar a epidemiologia da Leishmaniose Visceral (LV) no Município de Fortaleza- CE, no período de 2001 a 2007, e sua distribuição por Secretaria Executiva Regional (SER). Métodos: Os dados foram coletados na célula de Vigilância Epidemiológica da Secretaria Municipal de Saúde (SMS) de Fortaleza, através de levantamento epidemiológico sobre a prevalência da endemia humana por ano, segundo o sexo, a faixa etária, o número de casos por SER e a taxa de letalidade. Resultados: Dentre os 1051 casos com identificação do sexo, 685 eram do gênero masculino, representando 65,1%; a faixa etária mais acometida estava entre 1 a 4 anos de idade, com 240 casos (22,8%); a maior incidência observada ocorreu em 2007, na SER III (21,9/100.000 hab.), e 51 óbitos foram registrados no período, na capital, em decorrência da doença. Conclusão: Neste estudo, constatou-se que a LV no município de Fortaleza encontra-se em processo de urbanização, onde o número de casos é crescente com o passar dos anos e seguindo em direção às SER centrais. Observou-se que as SER III, V e VI são as que mais necessitam de investimento para o controle da doença.
Pathophysiology of Postoperative Ileus (1977)

In eight dogs, cellotomy, rubbing the small bowel, and exposing it to air suppressed the migrating bursts of action potentials and contractions that occur in the gastrointestinal tract during fasting and greatly slowed (one to three days) the gastrointestinal transit of 7-mm plastic spheres. The operation also caused a transient one-day increase in the concentration of epinephrine and a more prolonged five-day increase in the concentration and norepinephrine in arterial and venous plasma. Phentolamine mesylate and propranolol hydrochloride prevented the inhibition of the bursts of gastric action potentials brought about by operation, but these drugs did not alter the inhibition of the small intestinal action potentials or the speed of gastrointestinal transit of spheres.
Application of newer clearance techniques for the determination of glomerular filtration rate (1998)

Glomerular filtration rate (GFR) is the standard measure of renal function and is critical for the management of renal diseases. Rigorous assessment of GFR requires the measurement of renal clearance of a filtration marker, such as inulin. This method, however, is not suitable for routine clinical practice. Labelled compounds as alternative filtration markers provide accurate and precise GFR measurement, but their use may be limited for safety reasons. Thus investigators have proposed clearance procedures using minute doses of non-radioactive contrast agents, including iothalamate and iohexol. Their renal clearance provides similar accuracy as inulin clearance in GFR estimation, but the need of urine collection again poses certain limitations to the procedure. Thus, plasma clearance of suitable exogenous markers, such X-ray contrast media, has been suggested for measuring renal function, in which the elimination rate of the tracer after a single intravenous injection is evaluated. Plasma clearance of these markers estimated by multiple blood samples provides precise information, but repeated sampling makes this method cumbersome. Abbreviated kinetic profiles have been proposed to predict GFR from the plasma disappearance curve. The simplified method that uses a one-compartment model corrected by the Bröchner-Mortensen formula gives an excellent correlation with inulin clearance and is currently employed for measuring GFR in multi-centre clinical trials.
24 GHz Balanced Doppler Radar Front-End With Tx Leakage Canceller for Antenna Impedance Variation and Mutual Coupling (2011)

A new balanced Doppler radar front-end architecture with Tx leakage canceller for antenna impedance variation and antenna mutual coupling is proposed. Consisting of two quadrature hybrids, two ring hybrids and 4-port feed antenna system, the proposed balanced structure achieves high transmit/receive (Tx/Rx) isolation stable to antenna impedance variation and antenna mutual coupling. The proposed 4-port feed antenna is configured by dual fed 2 × 1 patch array having 6.97 dBi and 5.65 dBi of measured Tx and Rx peak gain, respectively. In addition, the proposed architecture undergoes no power loss in both transmit and receive paths, and obtains the measured Tx/Rx isolation of more than 45 dB stable at 24 GHz regardless of the load variation. The proposed architecture that can determine the speed as low as 0.5 mm/s (0.078 Hz Doppler shift) is theoretically and experimentally analyzed for high isolation despite of antenna mismatch.
miR‐223 suppresses differentiation of tumor‐induced CD11b<sup>+</sup>Gr1<sup>+</sup>myeloid‐derived suppressor cells from bone marrow cells (2011)

Tumor-associated factors are related to increased accumulation of CD11b(+) Gr1(+) myeloid-derived suppressor cells (MDSCs). However, the exact mechanism of how genetic factors control the expansion of MDSCs in tumor-bearing hosts remains elusive. Herein, we found that tumor-associated MDSCs and their subsets, mononuclear MDSCs and polymorphonuclear MDSCs, have decreased expression of miR-223 when compared to CD11b(+) Gr1(+) cells from the spleen of disease-free mice. With the differentiation of CD11b(+) Gr1(+) MDSCs from bone marrow cells (BMCs) upon exposure to tumor-associated factors, the expression of both pri-miR-223 and mature miR-223 was downregulated, indicating that the expression of miR-223 could be regulated by tumor-associated factors. Interestingly, miR-223 remarkably inhibits differentiation of BMCs into CD11b(+) Gr1(+) MDSCs in the presence of tumor-associated factors by targeting myocyte enhancer factor 2C (MEF2C). Using reconstituted s.c. tumor models, miR-223 also suppresses accumulation of CD11b(+) Gr1(+) MDSCs, whereas its targeting molecule MEF2C increases the number of MDSCs. Tumor growth is slower in mice infused by miR223-engineered BMCs than in mice infused with control transfected BMCs. As miR-223 and its target molecule MEF2C are highly conserved between mice and humans, the modulation of miR-223 in tumor-induced CD11b(+) Gr1(+) MDSCs may exert an important role in controlling the increased accumulation of CD11b(+) Gr1(+) MDSCs in patients with tumor.
Krypton-Crypto-based access control system (2003)

The authors describe a cryptography-based access control system for the IBM PC. The system implements the following functions: access control on PC boot time; transparent data ciphering on hard and floppy disks; access control on logical drives on hard disks (read-and-write access, read-only access, and inhibit access); and file and data block ciphering. The hardware and software are discussed. Short descriptions of the structure, the base function, and principles of implementation are given.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Characterization of a receptor for interleukin-5 on human eosinophils and the myeloid leukemia line HL-60 (1991)

Interleukin-5 (IL-5) promotes the growth and differentiation of human eosinophils and may regulate the selective eosinophilia and eosinophil activation seen in certain diseases. Radiolabeled recombinant human IL-5 (hIL-5) was used to characterize the IL-5 receptor present on normal human eosinophils and on the myeloid leukemia line HL-60, which can be induced to differentiate into eosinophilic cells. Binding studies with eosinophils and HL-60 cells grown under alkaline conditions demonstrated similar high-affinity binding sites for hIL-5 on both cell types with kd values of approximately 400 pmol/L. The binding observed was specific in that it was not inhibited by hIL-3, human granulocyte-macrophage colony-stimulating factor, or hIL-2. Binding studies with a number of other human cell lines, including a B-lymphoma line, and with lymphocyte and neutrophil preparations were also performed, but IL-5 receptors were not detectable on these cells. The number of hIL-5 receptors on HL-60 cells could be correlated with its propensity to differentiate towards an eosinophilic cell type. Expression of hIL-5 receptors on HL-60 cells was upregulated by butyric acid under alkaline conditions, downregulated by hIL-3, virtually eliminated by dimethyl sulfoxide and hIL-5, while hIL-2 had no detectable effect. One major 125I-hIL-5-crosslinked complex of 75 to 85 Kd in Mr was detected on HL-60 cells using crosslinking agents giving a molecular mass of 55 to 60 Kd for the hIL-5 receptor itself. Studies using cellular autoradiography showed that IL-5 receptors were evenly distributed on eosinophils but that receptor distribution on HL-60 cells was noticeably heterogeneous. Eosinophils were the only cells in slides prepared from peripheral blood that had detectable levels of IL-5 receptors in agreement with the specific action of IL-5 on the human eosinophil lineage.
Limited penetration of methotrexate into human osteosarcoma spheroids as a proposed model for solid tumor resistance to adjuvant chemotherapy. (1980)

It is generally accepted that oxygen has a limited ability to diffuse into solid tumor masses. However, the question of the ability of chemotherapy agents to penetrate solid tumor masses has not been evaluated. This clearly would have an impact on the ability of chemotherapy to control microscopic disease during the "avascular" phase of growth. An attempt was made to evaluate the ability of methotrexate to penetrate solid tumor masses when grown in three dimensions (spheroids). Since methotrexate is used in the clinical management of human osteosarcoma, we chose this drug-tumor combination for our studies. This was done by growing human osteosarcoma cells into spheroids and exposing spheroids of various sizes to tritiated methotrexate. Audioradiographs were obtained from sections through the center of spheroids of various sizes. Our findings suggest that methotrexate has a limited ability to penetrate into avascular tumor masses when grown in three dimensions. This is most evident when the tumor masses are approximately 250 micron and larger in diameter. In addition, we compared the degree of penetration of methotrexate to the growth fraction of the tumor, as measured by tritiated thymidine, and found that the growth fraction was much greater than the fraction of cells reached by methotrexate. We conclude that the limited ability of methotrexate to penetrate solid tumor masses offers an alternative explanation for the limited effectiveness of methotrexate when used as an adjuvant for osteosarcoma. We question whether the established biochemical mechanisms for methotrexate resistance are comprehensive explanations for its limited clinical effectiveness.
A new family of serine-type peptidases related to prolyl oligopeptidase (1991)

A new family of serine-type peptidases al., 1991), and essential catalytic residues were identified as Ser 54 related to prolyl oligopeptidase and His680 by reaction with active-site-directed reagents (Rennex et al., 1991; Stone et al., 1991). No significant resemblance was
Hamlet Versus Lear: Cultural Politics and Shakespeare's Art. By R. A. Foakes. New York: Cambridge University Press, 1993; pp. x + 262. $49.95 cloth. - The Development of Shakespeare's Theater. Edited by John H. Astington. New York: AMS Press, 1992; pp. viii + 208, 43 illustrations. $34.50 cloth. - Drama and Market in the Age of Shakespeare. By Douglas Bruster. New York: Cambridge University Press, 1992; pp. xv + 164. $39.95 cloth. - Citizen Shakespeare: A Social and Political Portrait. By James C. Humes. Westport, CT: Praeger, 1993; pp. xxiii + 167. $42.95 cloth. (1994)

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Liver-derived human mesenchymal stem cells: a novel therapeutic source for liver diseases (2016)

Mesenchymal stem cells (MSCs) represent an attractive cell type for research and therapy due to their ability to proliferate, differentiate, modulate immune reactions, and secrete trophic factors. MSCs exist in a multitude of tissues, including bone marrow, umbilical cord, and adipose tissues. Moreover, MSCs have recently been isolated from the liver. Compared with other MSC types, liver-derived human MSCs (LHMSCs) possess general morphologies, immune functions, and differentiation capacities. Interestingly, LHMCSs produce higher levels of pro-angiogenic, anti-inflammatory, and anti-apoptotic cytokines than those of bone marrow-derived MSCs. Thus, these cells may be a promising therapeutic source for liver diseases. This paper summarizes the biological characteristics of LHMSCs and their potential benefits and risks for the treatment of liver diseases.
Polypeptide Phosphorylation in Adenovirus-Infected Cells (1977)

Cells infected with human adenovirus type 5 have been labelled with 32P-orthophosphate under various conditions and extracts examined, after denaturation in sodium dodecyl sulphate (SDS), by polyacrylamide gel electrophoresis (PAGE) followed by autoradiography. A number of polypeptides appear to be phosphorylated specifically as a result of infection. Early in infection, phosphorylation of a polypeptide of apparent mol. wt. 26 K associated with ribosomes can be detected. Two other phosphorylated polypeptides of apparent mol. wt. 72 K and 18 K can also be seen, the former being mainly confined to the nucleus and capable of being precipitated by the previously described virus-specific P antiserum. The 18 K phosphorylated polypeptide is found mainly in association with membrane fractions. Later in infection phosphorylated polypeptides of apparent mol. wt. 100 K and 39 K can be recognized, the former being associated with ribosomes but removed, however, with a high salt wash; the latter component is mainly detected in the nucleus. Analysis of the purified 32P-labelled virus by the SDS PAGE technique indicated that a structural polypeptide of apparent mol. wt. 66 K (IIIa) was also phosphorylated.
Cyclodehydration of 1,4-butanediols by pentaethoxyphosphorane (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCyclodehydration of 1,4-butanediols by pentaethoxyphosphoraneDonald B. Denney, Dorothy Z. Denney, and John J. GigantinoCite this: J. Org. Chem. 1984, 49, 15, 2831–2832Publication Date (Print):July 1, 1984Publication History Published online1 May 2002Published inissue 1 July 1984https://pubs.acs.org/doi/10.1021/jo00189a044https://doi.org/10.1021/jo00189a044research-articleACS PublicationsRequest reuse permissionsArticle Views318Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
O MINISTÉRIO ECLESIÁSTICO E O SOFRIMENTO INTRAPSÍQUICO (RE)VELADO DESSE TRABALHO (2016)

Este artigo objetiva apresentar o sofrimento intrapsíquico oriundo do trabalho no ministério eclesiástico, dando enfoque aos pastores evangélicos. Propôs-se a investigar o contexto e as situações que favorecem o aparecimento de doenças físicas, emocionais e psicossomáticas que podem prejudicar o desempenho ocupacional e o relacionamento na sociedade contemporânea. O viés adotado na pesquisa foi qualitativo e bibliográfico, com aporte de um Estudo de Caso, onde procura enfocar os conflitos internos e as tensões psíquicas com um apanhado da visão psicanalítica desses problemas. Aborda-se também a questão do sofrimento humano, com perspectiva religiosa. Além disso, apresenta as principais tensões que o pastor e sua família estão submetidos. Por fim, é apresentado um testemunho referente algumas insatisfações e pressões sofridas por um pastor, que comprova as teorias apresentadas. As considerações finais denotam que é preciso continuar a busca para a solução destes sofrimentos e, consequentemente, melhorar o desempenho ocupacional no meio eclesiástico.
Professor King and the Health Law Curriculum (1991)

Swift tells us that "vision is the art of seeing things invisible."'According to Justice Holmes, the cosmos is interrelated: "To be master of any branch of knowledge, you must master those which lie next to it; and thus to know anything you must know all."' The line between law and medicine has always been distinct and has seemingly hardened and grown bolder over the centuries.But vision is not only the art of seeing the invisible; it is the art of dispelling the visible, and Professor Josephine Y. King is a pioneer in demonstrating that this line is in part an illusion.It is not easy to make changes in a law school curriculum.As in other institutions, a law school has its own conventions, and tradition is a form of inertia that does not respond quickly to the force of logic or circumstance.Lawyers and judges like the predictable and are comfortable with tradition.Making changes interrupts this pleasant world; it is disconcerting to face the unfamiliar, and it is tempting to hold to a practice because it is a groove already cut in a trackless plain.It is especially hard to introduce change into the health law curriculum, a field steeped, so it would initially appear, in the discipline of an age and tradition similar to law, and founded and overseen by professionals of the medical arts.There are, for instance, superficial parallels in the development of professionalism in law and medicine during the last 400 years.The English bar was organized early, by terms of function, into barristers and solicitors.English doctors at almost the same time were divided also by function-into physicians who only observed, speculated, and prescribed, and surgeons who engaged in manual treatment and also prescribed; the surgeons belonged to the same guild as barbers.'Moreover, lawyers and doctors adhered to ethical rules of conduct imposed by the profession by which not only competence to perform, but also devotion to the client's or patient's interest beyond profit, were recognized as predominant objectives. 4 In time, both professions became regulated by licensing procedures established by the state.'
Granulosa cell-derived insulin-like growth factor (IGF) binding proteins are inhibitory to IGF-I hormonal action. Evidence derived from the use of a truncated IGF-I analogue. (1992)

An increasing body of information now suggests that insulin-like growth factor (IGF) binding proteins (BPs) may serve as antigonadotropins at the level of the ovary. It is the objective of the present communication to evaluate the functional role of endogenous (granulosa cell-derived) IGFBPs by exploiting the unique properties of des(1-3)IGF-I, a naturally occurring IGF-I analogue characterized as a weak ligand of IGFBPs but not of type I IGF receptors. Given IGFBP-replete circumstances, des(1-3)IGF-I proved more potent (10-fold) than its intact counterpart in promoting the follicle stimulating hormone (FSH)-stimulated accumulation of progesterone by cultured rat granulosa cells. In contrast, des(1-3)IGF-I proved virtually equipotent to the unmodified principle under IGFBP-deplete circumstances. Taken together, these findings are in keeping with the notion and that the apparently enhanced potency of des(1-3)IGF-I (under IGFBP-replete conditions) is due to its diminished affinity for endogenously generated IGFBPs and that rat granulosa cell-derived IGFBPs are inhibitory to IGF (and thus inevitably to gonadotropin) hormonal action. Accordingly, the reported ability of gonadotropins to attenuate IGFBP release by granulosa cells may be designed to enhance the bioavailability of endogenously generated IGFs in the best interest of ovarian steroidogenesis.