gebhart/patrepeval huggingface dataset:
The use of fundamental frequency for lexical segmentation in listeners with cochlear implants (2009)

Fundamental frequency (F0) variation is one of a number of acoustic cues normal hearing listeners use for guiding lexical segmentation of degraded speech. This study examined whether F0 contour facilitates lexical segmentation by listeners fitted with cochlear implants (CIs). Lexical boundary error patterns elicited under unaltered and flattened F0 conditions were compared across three groups: listeners with conventional CI, listeners with CI and preserved low-frequency acoustic hearing, and normal hearing listeners subjected to CI simulations. Results indicate that all groups attended to syllabic stress cues to guide lexical segmentation, and that F0 contours facilitated performance for listeners with low-frequency hearing.
Differential stabilization by netropsin of inducible B-like conformations in deoxyribo-, ribo- and 2′-deoxy-2′-fluororibo-adenosine containing duplexes of (dA)<sub>n</sub>(dT)<sub>n</sub>and (dA)<sub>n</sub>(dU)<sub>n</sub> (1982)

Six polynucleotide duplexes containing polydeoxyadenylic acid, polyadenylic acid or poly-2'-deoxy-2'-fluoro-adenylic acid in one strand, and polydeoxyuridylic acid or polydeoxythymidylic acid in the other strand have been studied by circular dichroism, ionic strength dependence of melting temperatures and binding of the DNA specific antibiotic netropsin. Circular dichroism spectra of (dA)n . (dT)n and (dA)n . (dU)n indicated the presence of the B-form of DNA, while those of (dAfl)n . (dT)n and (rA)n . (dT)n (and the corresponding (dU)n hybrids) indicated the presence of the A-form. (dAfl)n . (dT)n and (dAfl)n . (dU)n bound netropsin only slightly less than the (dA)n containing duplexes, while replacement by (rA)n decreased netropsin binding to a large degree. Since netropsin requires B-DNA for binding, it is concluded that the A to B transition is facilitated in the case of fluorine substitution in the sugar moiety, while the 2'-OH group greatly limits this conformational change.
Influence of diabetes mellitus on heart failure risk and outcome (2003)

Our aim is to summarize and discuss the recent literature linking diabetes mellitus with heart failure, and to address the issue of the optimal treatment for diabetic patients with heart failure. THE STUDIES LINKING DIABETES MELLITUS (DM) WITH HEART FAILURE (HF) : The prevalence of diabetes mellitus in heart failure populations is close to 20% compared with 4 to 6% in control populations. Epidemiological studies have demonstrated an increased risk of heart failure in diabetics; moreover, in diabetic populations, poor glycemic control has been associated with an increased risk of heart failure. Various mechanisms may link diabetes mellitus to heart failure: firstly, associated comorbidities such as hypertension may play a role; secondly, diabetes accelerates the development of coronary atherosclerosis; thirdly, experimental and clinical studies support the existence of a specific diabetic cardiomyopathy related to microangiopathy, metabolic factors or myocardial fibrosis. Subgroup analyses of randomized trials demonstrate that diabetes is also an important prognostic factor in heart failure. In addition, it has been suggested that the deleterious impact of diabetes may be especially marked in patients with ischemic cardiomyopathy. TREATMENT OF HEART FAILURE IN DIABETIC PATIENTS : The knowledge of the diabetic status may help to define the optimal therapeutic strategy for heart failure patients. Cornerstone treatments such as ACE inhibitors or beta-blockers appear to be uniformly beneficial in diabetic and non diabetic populations. However, in ischemic cardiomyopathy, the choice of the revascularization technique may differ according to diabetic status. Finally, clinical studies are needed to determine whether improved metabolic control might favorably influence the outcome of diabetic heart failure patients.
Sampling-Based Path Planning on Configuration-Space Costmaps (2010)

This paper addresses path planning to consider a cost function defined over the configuration space. The proposed planner computes low-cost paths that follow valleys and saddle points of the configuration-space costmap. It combines the exploratory strength of the Rapidly exploring Random Tree (RRT) algorithm with transition tests used in stochastic optimization methods to accept or to reject new potential states. The planner is analyzed and shown to compute low-cost solutions with respect to a path-quality criterion based on the notion of mechanical work. A large set of experimental results is provided to demonstrate the effectiveness of the method. Current limitations and possible extensions are also discussed.
Tolerance and Tremor Rebound following Long-Term Chronic Thalamic Stimulation for Parkinsonian and Essential Tremor (1999)

Fifty-eight patients, 36 with essential tremor (ET) and 22 with Parkinson's disease (PD), received deep brain stimulation (DBS) in the thalamic ventral intermediate (Vim) nucleus. The mean follow-up was 17 months for ET and 21 months for PD patients. Stimulation parameters were adjusted as needed, at various intervals after surgery. Results were assessed using routine clinical evaluation and established outcome scales. All patients needed incremental increase in stimulation parameters at various intervals during the first 6-12 months after surgery. The mean voltage 1 week postoperatively was 1. 45 V in PD patients, and 1.37 V in ET patients. Twelve months later, the figures were 2.14 V in PD and 2.25 V in ET patients. At 1 year, the Essential Tremor Rating Scale (ETRS) improved from 54 to 28 (p < 0.0001). The motor part of the Unified Parkinson's Disease Rating Scale (UPDRS) improved from 37 to 26 (p < 0.01). Tremor items of the UPDRS improved more markedly (p < 0.0001). One week postoperatively 90% of PD, and 89% of ET patients were tremor free. One year later, 70% of PD and 60% of ET patients remained mostly tremor free. Upon switching off stimulation, there was a clear tendency for tremor rebound (p = 0.07) in the PD group, requiring continuous 24-hour stimulation in some patients. Permanent non-adjustable ataxia was induced by stimulation in 2 PD patients.
Insertional Mutagenesis in the <i>n</i> -Alkane-Assimilating Yeast <i>Yarrowia lipolytica</i> : Generation of Tagged Mutations in Genes Involved in Hydrophobic Substrate Utilization (2001)

Tagged mutants affected in the degradation of hydrophobic compounds (HC) were generated by insertion of a zeta-URA3 mutagenesis cassette (MTC) into the genome of a zeta-free and ura3 deletion-containing strain of Yarrowia lipolytica. MTC integration occurred predominantly at random by nonhomologous recombination. A total of 8,600 Ura(+) transformants were tested by replica plating for (i) growth on minimal media with alkanes of different chain lengths (decane, dodecane, and hexadecane), oleic acid, tributyrin, or ethanol as the C source and (ii) colonial defects on different glucose-containing media (YPD, YNBD, and YNBcas). A total of 257 mutants were obtained, of which about 70 were affected in HC degradation, representing different types of non-alkane-utilizing (Alk(-)) mutants (phenotypic classes alkA to alkE) and tributyrin degradation mutants. Among Alk(-) mutants, growth defects depending on the alkane chain length were observed (alkAa to alkAc). Furthermore, mutants defective in yeast-hypha transition and ethanol utilization and selected auxotrophic mutants were isolated. Flanking borders of the integrated MTC were sequenced to identify the disrupted genes. Sequence analysis indicated that the MTC was integrated in the LEU1 locus in N083, a leucine-auxotrophic mutant, in the isocitrate dehydrogenase gene of N156 (alkE leaky), in the thioredoxin reductase gene in N040 (alkAc), and in a peroxine gene (PEX14) in N078 (alkD). This indicates that MTC integration is a powerful tool for generating and analyzing tagged mutants in Y. lipolytica.
Quantum interference devices and field-effect transistors: A switch energy comparison (1993)

We compare quantum interference devices, exemplified by a resonant tunnel transistor, an Aharonov–Bohm interferometer, and a Y-branch switch, to field-effect transistors regarding their capability to reach fundamentally limited switch energies as well as their normalized transconductance. The resonant tunnel transistor is found to behave similarly to the field-effect transistor (FET). The Aharonov–Bohm interferometer is essentially equivalent to a single-mode Y-branch switch, while the Y branch has an advantage in allowing multimode operation. The normalized transconductance of these two devices can be an order of magnitude larger than for a FET.
Functional analysis of the nuclear proteome of human A549 alveolar epithelial cells by HPLC‐high resolution 2‐D gel electrophoresis (2006)

The airway epithelial cell plays a central role in coordinating airway inflammatory responses, where significant changes in the proteome occur in response to infectious stimuli. To further understand the spectrum of proteins and the biological processes they control, we have initially determined the nuclear proteome of human type II-like alveolar epithelial cells (A549) using a sequential method of organellar enrichment followed by HPLC prefractionation prior to 2-DE-based protein identification using MALDI-TOF MS. This approach yielded 719 high-confidence identifications, 433 mapping to unique gene identifiers. Expert classification showed that these proteins controlled chromatin remodeling, protein refolding, cytoskeletal structure, membrane function, metabolic processes, mitochondrial function, RNA binding, protein synthesis, signaling, and transcription factor activities. The proteins were mapped to gene ontology classifications, where metabolism and catalytic activity functions were significantly enriched, representing 43 and 32% of the protein set, respectively. Pathways analysis indicated a protein network affecting tumor necrosis factor-nuclear factor-kappaB signaling pathway interacting with intermediate cytoskeletal filaments. Forty-five proteins of unknown function were subjected to domain analysis and inferred to have additional nuclear functions controlling purine nucleotide metabolism and protein-protein interactions. This database represents the most comprehensive data set of mammalian nuclear proteins and will serve as a foundation for further discovery.
Representing fundamental frequency contours generated by HMM-based speech synthesis using generation process model (2011)

Frame-by-frame representation is not appropriate for prosodic features, which are tightly related to speech units spreading a wide time span, such as words, phrases and so on. This causes an inherit problem in fundamental frequency (F <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</inf> ) contour generation by HMM-based speech synthesis. A method is developed to modify F <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</inf> contours in the framework of a generation process model by referring to linguistic information of input text (word boundary and accent type). It takes F <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</inf> variances obtained through HMM-based speech synthesis into account during the process. Through a listening experiment on synthetic speech, the method is proved to generate better quality as compared to the HMM-based speech synthesis on average. Since the generation process model can clearly relate its commands and linguistic (and para-/non- linguistic) information, the method has an additional advantage; changing speech styles, and /or adding further information (such as emphasis) can be easily done through manipulating the commands.
Recognition of conserved antigens by Th17 cells provides broad protection against pulmonary<i>Haemophilus influenzae</i>infection (2018)

Nontypeable <i>Haemophilus influenzae</i> (NTHi) is a major cause of community acquired pneumonia and exacerbation of chronic obstructive pulmonary disease. A current effort in NTHi vaccine development has focused on generating humoral responses and has been greatly impeded by antigenic variation among the numerous circulating NTHi strains. In this study, we showed that pulmonary immunization of mice with killed NTHi generated broad protection against lung infection by different strains. While passive transfer of immune antibodies protected only against the homologous strain, transfer of immune T cells conferred protection against both homologous and heterologous strains. Further characterization revealed a strong Th17 response that was cross-reactive with different NTHi strains. Responding Th17 cells recognized both cytosolic and membrane-associated antigens, while immune antibodies preferentially responded to surface antigens and were highly strain specific. We further identified several conserved proteins recognized by lung Th17 cells during NTHi infection. Two proteins yielding the strongest responses were tested as vaccine candidates by immunization of mice with purified proteins plus an adjuvant. Immunization induced antigen-specific Th17 cells that recognized different strains and, upon adoptive transfer, conferred protection. Furthermore, immunized mice were protected against challenge with not only NTHi strains but also a fully virulent, encapsulated strain. Together, these results show that the immune mechanism of cross-protection against pneumonia involves Th17 cells, which respond to a broad spectrum of antigens, including those that are highly conserved among NTHi strains. These mechanistic insights suggest that inclusion of Th17 antigens in subunit vaccines offers the advantage of inducing broad protection and complements the current antibody-based approaches.
Scalable Motif-aware Graph Clustering (2017)

We develop new methods based on graph motifs for graph clustering, allowing more efficient detection of communities within networks. We focus on triangles within graphs, but our techniques extend to other clique motifs as well. Our intuition, which has been suggested but not formalized similarly in previous works, is that triangles are a better signature of community than edges. We therefore generalize the notion of conductance for a graph to triangle conductance, where the edges are weighted according to the number of triangles containing the edge. This methodology allows us to develop variations of several existing clustering techniques, including spectral clustering, that minimize triangles split by the cluster instead of edges cut by the cluster. We provide theoretical results in a planted partition model to demonstrate the potential for triangle conductance in clustering problems. We then show experimentally the effectiveness of our methods to multiple applications in machine learning and graph mining.
Properties of Sandwich-Type Structures as Acoustic Windows (1957)

The acoustic transmission of a sandwich consisting of a pair of plane parallel solid plates immersed in a liquid has been investigated theoretically and experimentally. Not only the dilatational waves, but also the shear waves, are considered. Results show greatly improved transmission characteristics over those of single thick metal plates with respect to dependence on both frequency and angle of incidence. Theoretical transmission curves for a sandwich of two steel plates have been prepared to exhibit the dependence of transmission on frequency, on ratio of plate thickness to wavelength and separation to wavelength, and on angle of incidence, respectively. Calculated transmission curves for single steel plates, including half-wave plates, are shown for comparison. An experimental test was made on a steel sandwich with lateral dimensions of the order of two wavelengths and plate thickness-to-wavelength (in the steel) ratio equal to 0.05. The measured transmission losses are within ±4 db of the calculated values.
Engineering Privacy (2008)

In this paper we integrate insights from diverse islands of research on electronic privacy to offer a holistic view of privacy engineering and a systematic structure for the discipline's topics. First we discuss privacy requirements grounded in both historic and contemporary perspectives on privacy. We use a three-layer model of user privacy concerns to relate them to system operations (data transfer, storage and processing) and examine their effects on user behavior. In the second part of the paper we develop guidelines for building privacy-friendly systems. We distinguish two approaches: "privacy-by-policy" and "privacy-by-architecture." The privacy-by-policy approach focuses on the implementation of the notice and choice principles of fair information practices (FIPs), while the privacy-by-architecture approach minimizes the collection of identifiable personal data and emphasizes anonymization and client-side data storage and processing. We discuss both approaches with a view to their technical overlaps and boundaries as well as to economic feasibility. The paper aims to introduce engineers and computer scientists to the privacy research domain and provide concrete guidance on how to design privacy-friendly systems.
Real-Time, In Vivo Measurement of Radiation Dose during Radioimmunotherapy in Mice Using a Miniature MOSFET Dosimeter Probe (1995)

This report presents the first real-time measurement of absorbed radiation dose during radioimmunotherapy in mice. Dose rate and total dose at the center of the tumor were measured after administration of 90Y-labeled antibodies using a miniature metal oxide semiconductor field-effect transistor radiation dosimeter probe which was inserted into the center of the tumor volume. Continuous real-time measurements were made for as long as 23 h after injection of the radiolabeled antibodies. Comparison of the real-time dose-rate measurements with estimates based on the MIRD formalism indicates good agreement. The real-time measurements are further compared to measurements made in a second experiment in which groups of mice were sacrificed at individual times after injection of the same radiolabeled antibodies. The real-time measurements agree well with the measurements in excised tumors. The real-time measurements have greater time resolution and are much more efficient than traditional uptake measurements.
Effects of Freezing Methods and Storage Temperature on Flavor Stability and Ester Contents of Frozen Strawberries. (1993)

Berries of three strawberry cultivars, Hoko-wase, Toyonaka, and Nyoho, were quickfrozen and stored at -20 , -40 0, and -80 C, for 6 months. Strawberries were also frozen slowly or dipped into a sugar solution before freezing and stored at -20 C.
An experimental investigation of the shale inhibition properties of a quaternary amine compound (2013)

Depleting oil reserves and increased costs of the oil and gas recoveries have created the need to drill in challenging formations. When drilled through, shale formations in particular always generated a wide variety of problems if conventional water-based muds are used. Furthermore, the complexity and variations in shales have compounded the task of developing suitable drilling fluids. In light of these problems, the study of shale properties and their interactions with fluids will continue to be a much-needed source of information in drilling industry. In this study a low molecular weight quaternary amine compound, which is provided by KarKim Drilling Fluids Inc., and its mixtures with sodium and potassium chloride is investigated in the aspects of capillary suction times, hot rolling recoveries, methylene blue capacities and one-dimensional free swelling properties in order to compare performances of salts and amine compound. For all test methods quaternary amine concentration from 1% to 6% by volume were studied and seen that less amount of quaternary amine compound is needed in order to obtain close shale recoveries and shale volume change potential if compared with sodium and potassium chloride. This prevents the usage of high concentration of chlorides and hence provides environmental sensitiveness. Furthermore, it was concluded that combining an amount of salt with quaternary amine compound
Neurostimulation for Patients in Vegetative Status (1987)

Dorsal column stimulation has been used in four patients who were in a persistent vegetative state. There was improvement of the EEG in four patients and clinical improvement in three patients. Stimulation was for 12 hours per day at 100 Hz, 5 to 8 volts, and with a pulse width of 0.12 msec. The mechanism of improvement may involve changes in cerebral blood flow.
Visualization of secreted Hrp and Avr proteins along the Hrp pilus during type III secretion in <i>Erwinia amylovora</i> and <i>Pseudomonas syringae</i> (2001)

Pili are required for protein and/or DNA transfer from bacteria to recipient plant or bacterial cells, based on genetic evidence. However, it has never been shown directly that the effector proteins or DNA are localized along or inside the pili in situ. Failure to visualize an association of effector proteins/DNA with pili is the central issue in the debate regarding the exact function of pili in protein and DNA transfer. In this study, a newly developed in situ immunogold labelling procedure enabled visualization of the specific localization of type III effector proteins of Erwinia amylovora and Pseudomonas syringae pv. tomato along the Hrp pilus, but not along the flagellum or randomly in the intercellular space. In contrast, PelE, a pectate lyase secreted via the type II protein secretion system, was not associated with the Hrp pilus. These results provide direct evidence that type III secretion occurs only at the site of Hrp pilus assembly and that the Hrp pilus guides the transfer of effector proteins outside the bacterial cell, favouring the 'conduit/guiding filament' model.
Radiometric Calibration of LIDAR Intensity With Commercially Available Reference Targets (2008)

We present a new approach for radiometric calibration of light detection and ranging (LIDAR) intensity data and demonstrate an application of this method to natural targets. The method is based on 1) using commercially available sand and gravel as reference targets and 2) the calibration of these reference targets in the laboratory conditions to know their backscatter properties. We have investigated the target properties crucial for accurate and consistent reflectance calibration and present a set of ideal targets easily available for calibration purposes. The first results from LIDAR-based brightness measurement of grass and sand show that the gravel-based calibration approach works in practice, is cost effective, and produces statistically meaningful results: Comparison of results from two separate airborne laser scanning campaigns shows that the relative calibration produces repeatable reflectance values.
Identification of Biased Amino Acid Substitution Patterns in Human Immunodeficiency Virus Type 1 Isolates from Patients Treated with Protease Inhibitors (1999)

Human immunodeficiency virus type 1 (HIV-1) amino acid substitutions observed during antiretroviral drug therapy may be caused by drug selection, non-drug-related evolution, or sampling error introduced by the sequencing process. We analyzed HIV-1 sequences from 371 untreated patients and from 178 patients receiving a single protease inhibitor. Amino acid substitution patterns during treatment were compared with inferred substitution patterns arising evolutionarily without treatment. Our results suggest that most treatment-associated amino acid substitutions are caused by selective drug pressure, including substitutions not previously associated with drug resistance.