gebhart/patrepeval huggingface dataset:
A total synthesis of (.+-.)-bilobalide. (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA total synthesis of (.+-.)-bilobalide.Michael T. Crimmins, David K. Jung, and Jeffrey L. GrayCite this: J. Am. Chem. Soc. 1992, 114, 13, 5445–5447Publication Date (Print):June 1, 1992Publication History Published online1 May 2002Published inissue 1 June 1992https://pubs.acs.org/doi/10.1021/ja00039a077https://doi.org/10.1021/ja00039a077research-articleACS PublicationsRequest reuse permissionsArticle Views985Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Hydrogen peroxide induced adenosine diphosphate ribosyl transferase (ADPRT) response in patients with inflammatory bowel disease. (1988)

The sample population in this initial case control study of the adenosine diphosphate ribosyl transferase (ADPRT) response of inflammatory bowel disease patients included: 23 patients with ulcerative colitis (UC)-active and inactive, 13 patients with Crohn's disease (CD)-active and inactive, 14 first degree relatives of UC and CD patients, and 19 age-matched controls. Adenosine diphosphate ribosyl transferase activity was determined after one hour incubation with 1% plasma (the constitutive value) or with 1% plasma and 100 microM H2O2 (the activated value) with the resulting difference designated as the induced value. Statistically significant decrease in ADPRT activity was found for the constitutive, activated and induced values in human mononuclear leucocytes of UC and CD patients, compared with controls. The values in the first degree relatives of UC and CD patients were not significantly different from either the control or disease populations, indicating an intermediate ADPRT response. These results may be related to the nature of the immunological response of IBD patients and comparable with similar findings in other diseases with known DNA repair deficiencies--for example, colon cancer.
Immunological evaluation of rheumatoid arthritis patients treated with itolizumab (2015)

Rheumatoid arthritis is an autoimmune disease characterized by joint inflammation that affects approximately 1% of the general population. Itolizumab, a monoclonal antibody specific for the human CD6 molecule mainly expressed on T lymphocytes, has been shown to inhibit proliferation of T cells and proinflammatory cytokine production in psoriasis patients. We have now assessed the immunological effect of itolizumab in combination with methotrexate in rheumatoid arthritis by analyzing clinical samples taken from 30 patients enrolled in a clinical trial. T and B cell subpopulations were measured at different time points of the study. Plasma cytokine levels and anti-idiotypic antibody response to itolizumab were also evaluated. The combined treatment of itolizumab and methotrexate led to a reduction in the frequency of T cell subpopulations, and plasma levels of proinflammatory cytokines showed a significant decrease up to at least 12 weeks after treatment ended. No anti-idiotypic antibody response was detected. These results support the relevance of the CD6 molecule as a therapeutic target for the treatment of this disease.
Smooth Muscle-selective Alternatively Spliced Exon Generates Functional Variation in Cav1.2 Calcium Channels (2004)

Voltage-gated calcium channels play a major role in many important processes including muscle contraction, neurotransmission, excitation-transcription coupling, and hormone secretion. To date, 10 calcium channel alpha(1)-subunits have been reported, of which four code for L-type calcium channels. In our previous work, we uncovered by transcript-scanning the presence of 19 alternatively spliced exons in the L-type Ca(v)1.2 alpha(1)-subunit. Here, we report the smooth muscle-selective expression of alternatively spliced exon 9(*) in Ca(v)1.2 channels found on arterial smooth muscle. Specific polyclonal antibody against exon 9(*) localized the intense expression of 9(*)-containing Ca(v)1.2 channels on the smooth muscle wall of arteries, but the expression on cardiac muscle was low. Whole-cell patch clamp recordings of the 9(*)-containing Ca(v)1.2 channels in HEK293 cells demonstrated -9 and -11-mV hyperpolarized shift in voltage-dependent activation and current-voltage relationships, respectively. The steady-state inactivation property and sensitivity to blockade by nifedipine of the +/-exon 9(*) splice variants were, however, not significantly different. Such cell-selective expression of an alternatively spliced exon strongly indicates the customization and fine tuning of calcium channel functions through alternative splicing of the pore-forming alpha(1)-subunit. The generation of proteomic variations by alternative splicing of the calcium channel Ca(v)1.2 alpha(1)-subunit can potentially provide a flexible mechanism for muscle or neuronal cells to respond to various physiological signals or to diseases.
<i>Wnt-1-</i>dependent regulation of local E-cadherin and αN-catenin expression in the embryonic mouse brain (1994)

E-cadherin is transiently expressed in local regions of the embryonic mouse brain, which include several patchy areas on the mesencephalon and diencephalon and their roof plate and part of cerebellar rudiments. In the present study, we compared this E-cadherin expression with that of Wnt-1, which occurs in specific zones in the embryonic brain, and found certain spatiotemporal relations between them: Wnt-1 expression tended to run parallel or overlap with peripheries of the E-cadherin-positive areas. For example, in the dorsal midline, Wnt-1 was expressed at the middle of the roof plate, while E-cadherin was absent in the middle zone but detected in two arrays of marginal roof plate cells. Furthermore, alpha N-catenin, a cadherin-associated protein, was found to occur at the roof plate of the mesencephalon and diencephalon, coinciding with Wnt-1 expression. The expression of these molecules was then studied in two alleles of the Wnt-1 mutation, Wnt-1sw and Wnt-1neo. In mice homozygous for these mutant genes, E-cadherin expression in the roof plate was up-regulated; the middle E-cadherin-negative zone disappeared. Moreover, E-cadherin expression in the roof plate began earlier in the mutant mice than in wild-type mice. On the contrary, alpha N-catenin expression in the dorsal midline was suppressed in these mutants. These changes in cadherin and catenin expression occurred at the level of mRNA expression. These results suggest that the Wnt-1 signal is, either directly or indirectly, involved in the regulation of expression of E-cadherin and alpha N-catenin in restricted regions of the embryonic brain. This mechanism may contribute to the patterning of the expression of these adhesion-related proteins in the embryonic brain.
A measurement-based CAC strategy for ATM networks (2002)

In ATM networks, connection admission control (CAC) has been recognized as one of the most important means to provide satisfactory quality of service (QoS) and protect the network from congestion, especially for supporting real-time services such as voice and video. An efficient CAC strategy, which can both guarantee the QoS of admitted connections and achieve good resource utilization, then becomes a crucial issue for ATM network providers. The concept of a user-network traffic contract has been introduced by the ATM Forum. Starting from this point, we propose a measurement-based CAC strategy. We first discuss how to obtain an accurate description (traffic parameters) of user traffic by using on-line measurement in conjunction with dynamic renegotiation. The results show that the proposed strategy is reliable and simple to implement. We then move on to examine the possibility and methodology for exploiting the effect of statistical multiplexing in resource allocation to achieve higher network resource utilization.
Effect of Tetracycline on the Phagocytic Function of Human Leukocytes (1974)

Journal Article Effect of Tetracycline on the Phagocytic Function of Human Leukocytes Get access Arne Forsgren, Arne Forsgren From the Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota Search for other works by this author on: Oxford Academic PubMed Google Scholar David Schmeling, David Schmeling From the Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota Search for other works by this author on: Oxford Academic PubMed Google Scholar Paul G. Quie Paul G. Quie From the Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Infectious Diseases, Volume 130, Issue 4, October 1974, Pages 412–415, https://doi.org/10.1093/infdis/130.4.412 Published: 01 October 1974 Article history Received: 21 January 1974 Revision received: 09 April 1974 Published: 01 October 1974
A comparison between glutaraldehyde and diepoxide-fixed stentless porcine aortic valves: biochemical and mechanical characterization and resistance to mineralization. (1995)

As previously reported, we found that the fixation rate and thermal denaturation (shrink) temperature of the diepoxide-fixed tissue could be controlled by varying the concentration of the fixative as well as by adding alcohol and/or sodium chloride to the solution. In contrast to prior experience, however, we now found that the epoxide-fixed leaflets exhibited significantly higher resistance to mineralization compared to controls, but only when the tissue had not been exposed to phosphate ion.
APPLICATION OF TIME HISTORICAL DATA TO STRUCTURAL EVALUATION OF ASPHALT PAVEMENTS (1998)

FWD tests have been conducted on asphalt pavements with known profiles in order to collect a time historical data at one hour interval for 24 hours for all seasons. These data have been backcalculated to estimate layer moduli by the dynamic method using FEM. In comparison with the results from static backcalculation, the following matters are found; 1) The variation of the estimated layer moduli by the dynamic method is smaller than the static method. 2) Dynamic method can be used to evaluate the structural capacity suitably without prior-information concerning the layer moduli, which may be necessary for static method. 3) Even if same layer material is used, its backcalculated modulus is different depending thickness and material used in other layers.
Fruit Fly Control in Hawaii with Poison-Bait Sprays Containing Protein Hydrolysates (1952)

Journal Article Fruit Fly Control in Hawaii with Poison-Bait Sprays Containing Protein Hydrolysates Get access Loren F. Steiner Loren F. Steiner U.S.D.A., Agr. Res. Adm., Bur. of Entomology and Plant Quarantine Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Economic Entomology, Volume 45, Issue 5, 1 October 1952, Pages 838–843, https://doi.org/10.1093/jee/45.5.838 Published: 01 October 1952
Modulation of red cell band 4.1 function by cAMP-dependent kinase and protein kinase C phosphorylation. (1988)

Human erythrocyte protein 4.1 is phosphorylated in vivo by several protein kinases including protein kinase C and cAMP-dependent kinase. We have used cAMP-dependent kinase purified from red cells and protein kinase C purified from brain to test the effects of phosphorylation on band 4.1 function. In solution, each kinase catalyzed the incorporation of 1-4 mol of PO4/mol of band 4.1. Phosphorylation of band 4.1 by each kinase resulted in a significant (50-80%) reduction in the ability of band 4.1 to promote spectrin binding to F-actin. Direct measurement of spectrin-band 4.1 binding showed that phosphorylation by each kinase also caused dramatic reduction in this association. Phosphorylation of band 4.1 by each kinase for increasing time periods enabled us to demonstrate an approximately linear inverse relationship between PO4 incorporation into band 4.1 and spectrin binding. These results show that phosphorylation of band 4.1 by cAMP-dependent kinase and protein kinase C may be central to the regulation of red cell cytoskeletal organization and membrane mechanical properties.
Human Cholesteryl Ester Transfer Protein Gene Proximal Promoter Contains Dietary Cholesterol Positive Responsive Elements and Mediates Expression in Small Intestine and Periphery While Predominant Liver and Spleen Expression Is Controlled by 5′-distal Sequences (1996)

The plasma cholesteryl ester transfer protein (CETP) facilitates the transfer of high density lipoprotein cholesteryl esters to other lipoproteins and appears to be a key regulated component of reverse cholesterol transport. Earlier studies showed that a CETP transgene containing natural flanking sequences (-3.4 kilobase pairs (kbp) upstream, +2.2 kbp downstream) was expressed in an authentic tissue distribution and induced in liver and other tissues in response to dietary or endogenous hypercholesterolemia. In order to localize the DNA elements responsible for these effects, we prepared transgenic mice expressing six new DNA constructs containing different amounts of natural flanking sequence of the CETP gene. Tissue-specific expression and dietary cholesterol response of CETP mRNA were determined. The native pattern of predominant expression in liver and spleen with cholesterol induction was shown by a -3.4 (5'), +0.2 (3') kbp transgene, indicating no major contribution of distal 3'-sequences. Serial 5'-deletions showed that a -570 base pairs (bp) transgene gave predominant expression in small intestine with cholesterol induction of CETP mRNA in that organ, and a -370 bp transgene gave highest expression in adrenal gland with partial dietary cholesterol induction of CETP mRNA and plasma activity. Further deletion to -138 bp 5'-flanking sequence resulted in a transgene that was not expressed in vivo. Both the -3.4 kbp and -138 bp transgenes were expressed when transfected into a cultured murine hepatocyte cell line, but only the former was induced by treating the cells with LDL. When linked to a human apoA-I transgene, the -570 to -138 segment of the CETP gene promoter gave rise to a relative positive response of hepatic apoA-I mRNA to the high cholesterol diet in two out of three transgenic lines. Thus, 5'-elements between -3,400 and -570 bp in the CETP promoter endow predominant expression in liver and spleen. Elements between -570 and -370 are required for expression in small intestine and some other tissues, and elements between -370 and -138 contribute to adrenal expression. The minimal CETP promoter element associated with a positive sterol response in vivo was found in the proximal CETP gene promoter between -370 and -138 bp. This region contains a tandem repeat of a sequence known to mediate sterol down-regulation of the HMG-CoA reductase gene, suggesting either the presence of separate positive and negative sterol response elements in this region or the use of a common DNA element for both positive and negative sterol responses.
Mapping small GTP‐binding proteins on high‐resolution two‐dimensional gels by a combination of GTP binding and labeling with <i>in situ</i> periodateoxidized GTP (1994)

We compared two approaches to identify and map small GTP-binding proteins in combination with high-resolution two-dimensional (2-D) gel electrophoresis. The first approach involved direct GTP ligand binding after a renaturing transfer onto nitrocellulose. In the second, affinity labeling with in situ periodate-oxidized GTP was used in permeabilized cells (Peter, M. E., She, J., Huber, L. A. and Terhorst, C. Anal. Biochem. 1993, 210, 77-85). Analysis by 2-D gel electrophoresis revealed a number of distinct intracellular small GTP-binding proteins in Madine-darby canine kidney strain II cells (MDCKII). Using specific antibodies the electrophoretic coordinates of rab4, rap1a/b, and rap2 were identified for native as well as for crosslinked GTPases. These methods allow the identification of small GTP-binding proteins in total cell lysates and purified subcellular fractions, providing excellent markers throughout the course of differentiation and development.
Heterogeneously-integrated VCSEL using high-contrast grating on silicon (2015)

We present a unique heterogeneous integration approach for VCSELs on silicon using eutectic bonding. An electrically pumped III-V – silicon heterogeneous VCSEL is demonstrated using a high-contrast grating (HCG) reflector on silicon. CW output power >1.5 mW, thermal resistance of 1.46 K/mW, and 5 Gb/s direct modulation is demonstrated. We also explore the possibility of an all-HCG VCSEL structure that would benefit from stronger thermal performance, larger tuning efficiency, and higher direct modulation speeds.
Power estimation in sequential circuits (1995)

Article Power estimation in sequential circuits Share on Authors: Farid N. Najm ECE Dept. and Coordinated Science Lab., University of Illinois at Urbana-Champaign, Urbana, IL ECE Dept. and Coordinated Science Lab., University of Illinois at Urbana-Champaign, Urbana, ILView Profile , Shashank Goel ECE Dept. and Coordinated Science Lab., University of Illinois at Urbana-Champaign, Urbana, IL ECE Dept. and Coordinated Science Lab., University of Illinois at Urbana-Champaign, Urbana, ILView Profile , Ibrahim N. Hajj ECE Dept. and Coordinated Science Lab., University of Illinois at Urbana-Champaign, Urbana, IL ECE Dept. and Coordinated Science Lab., University of Illinois at Urbana-Champaign, Urbana, ILView Profile Authors Info & Claims DAC '95: Proceedings of the 32nd annual ACM/IEEE Design Automation ConferenceJanuary 1995 Pages 635–640https://doi.org/10.1145/217474.217602Online:01 January 1995Publication History 43citation319DownloadsMetricsTotal Citations43Total Downloads319Last 12 Months1Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Designing outside rail constraints (2004)

CMOS evolution introduces several problems in analog design. Gate-leakage mismatch exceeds matching tolerances requiring active cancellation techniques. One strategy to deal with the use of lower supply voltages is to operate critical parts at higher supply voltages, by exploiting combinations of thin and thick-oxide transistors.
Seal of confession: A strict obligation for priests (2013)

A famous case involving the seal of confession was that of Father Francis Douglas. In 1938, a New Zealand Columban priest, Father Francis Douglas was appointed to Pililla, a town near Manila in the Philippines. It was a difficult assignment, made worse by the Japanese occupation of the country in January 1942. In July 1943 he was asked to visit some guerrillas who said that they needed his priestly services. Afterwards, the Japanese then thought he was a spy. He was tortured for 3 days and presumably killed because among other things he would not break the seal of confession. Many regard him as a martyr for being faithful to his priestly obligations.
The Vibrational Behavior of a Multi-Shaft, Multi-Bearing System in the Presence of a Propagating Transverse Crack (1984)

The effects of a transverse crack on the dynamics of a multi-rotor, multi-bearing system have been studied experimentally using a spin rig. It is concluded that except for very large cracks, the vibrational behavior is similar to that of a slotted shaft with additional excitation due to the crack opening and closing. It confirms the theory, described elsewhere, that it is possible to calculate the behavior of a cracked and/or slotted rotor for a realistic turbogenerator model for crack depths sufficient to give a measurable vibration vector change. The dynamic stresses in the cracked shaft were also measured. The results show how the dynamic bending moment at the crack tip depends on the speed of rotation of the shaft and the crack depth. The results are compared with a theoretical treatment previously reported and good agreement obtained. It is concluded that for crack depths in excess of one third the way through, the shaft the dynamic bending moment must be used for fracture mechanics calculations.
Human rheumatoid factor cross-idiotypes. IV. Studies on WA XId-positive IgM without rheumatoid factor activity provide evidence that the WA XId is not unique to rheumatoid factors and is distinct from the 17.109 and G6 XIds. (1993)

The WA cross-idiotype (XId) is the major XId among human monoclonal rheumatoid factors (mRF) and is almost always associated with the light (L) chain XId, 17.109, and the heavy (H) chain XId, G6. A cell line, 35G6, was cloned that bears the WA XId, but shows no reactivity with immunoglobulin G (IgG) and is negative for the 17.109 and G6 XIds. The 35G6 L chain appears to be derived from the same VKIII-JKI genes as most WA mRFs L chains. In contrast to the WA mRFs H chains in which VH1 genes are used, the 35G6 IgM expresses a VH3 gene. Sequence comparisons with other WA XId-positive mRF suggested several common structural features that may be related to the WA XId and differences that may relate to lack of IgG reactivity. Cells similar to 35G6 have previously been described in pokeweed mitogen-stimulated cell lines of peripheral blood lymphocytes from normal individuals and patients with rheumatoid arthritis and type II mixed cryoglobulinemia. These observations were confirmed, and in addition, it was shown that the majority of WA XId-positive cells in these cultures were negative for the 17.109 and G6 XIds. The presence of the WA XId in the absence of IgG reactivity suggests that the WA XId is more directly associated with an antigen specificity other than IgG, and its association with RF activity may be incidental. It is postulated that these WA XId-positive RF-negative antibodies may serve a physiologic role as natural antibodies to a pervasive pathogen, and that IgG reactivity is a consequence of somatic diversification accompanying proliferation of the WA XId-positive RF-negative cell.