gebhart/patrepeval huggingface dataset:
<i>Neisseria meningitidis</i> App, a new adhesin with autocatalytic serine protease activity (2003)

Neisseria meningitidis is a Gram-negative bacterium which colonizes the human upper respiratory tract. Occasionally, it translocates to the bloodstream causing sepsis and from there it can cross the blood-brain barrier and cause meningitis. Many of the molecules, which mediate the interaction of N. meningitidis to host cells, are still unknown. Recently, App (Adhesion and penetration protein) was described as a member of the autotransporter family and a homologue to the Hap (Haemophilus adhesion and penetration) protein of Haemophilus influenzae, a molecule that plays a role in the interaction with human epithelial cells. In this study we expressed app in Escherichia coli in order to analyse the functional properties of the protein. We show that the protein is exported to the E. coli surface, processed by an endogenous serine-protease activity and released in the culture supernatant. Escherichia coli expressing app adhere to Chang epithelial cells, showing that App is able to mediate bacterial adhesion to host cells. The serine protease activity is localized at the amino-terminal domain, whereas the binding domain is in the carboxy-terminal region. The role of App in adhesion was confirmed also in N. meningitidis.
Analysis of flux pinning in<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:mi mathvariant="normal">Y</mml:mi><mml:msub><mml:mi mathvariant="normal">Ba</mml:mi><mml:mn>2</mml:mn></mml:msub><mml:msub><mml:mi mathvariant="normal">Cu</mml:mi><mml:mn>3</mml:mn></mml:msub><mml:msub><mml:mi mathvariant="normal">O</mml:mi><mml:mrow><mml:mn>7</mml:mn><mml:mo>−</mml:mo><mml:mi>δ</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math>films by nanoparticle-modified substrate surfaces (2006)

Enhanced in-field critical current density ${J}_{c}$ has been achieved in $\mathrm{Y}{\mathrm{Ba}}_{2}{\mathrm{Cu}}_{3}{\mathrm{O}}_{7\ensuremath{-}\ensuremath{\delta}}$ (YBCO) films grown on single crystal and biaxially textured metal substrate surfaces that were pretreated with second-phase nanoscale MgO and $\mathrm{Ba}\mathrm{Zr}{\mathrm{O}}_{3}$ particles. Nanoparticles were applied using wet chemical solution-based approaches. Results obtained in this study are compared with our previous investigations on surface modified substrates with sputter processed Ir nanoparticles. Cross-sectional TEM analysis and details of the field-orientation dependence of ${J}_{c}$ are found to be similar for both sputtered and solution processed nanoparticle species. Present results show a more uniform dependence of ${J}_{c}$ over all orientations of magnetic field, along with improved irreversibility behavior. Irrespective of the decoration technique, scaling behavior of the normalized volume pinning force density, ${F}_{p}$, demonstrates the similarity of pinning mechanisms for these YBCO films deposited on artificially modified substrates.
Blood esterases (1942)

Research Article| December 01 1942 Blood esterases Derek Richter; Derek Richter 1Central Pathological Laboratory (L.C.C.) and Mill Hill Emergency Hospital, London, N.W. 7 Search for other works by this author on: This Site PubMed Google Scholar Phyllis Godby Croft Phyllis Godby Croft 1Central Pathological Laboratory (L.C.C.) and Mill Hill Emergency Hospital, London, N.W. 7 Search for other works by this author on: This Site PubMed Google Scholar Biochem J (1942) 36 (10-12): 746–757. https://doi.org/10.1042/bj0360746 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation Derek Richter, Phyllis Godby Croft; Blood esterases. Biochem J 1 December 1942; 36 (10-12): 746–757. doi: https://doi.org/10.1042/bj0360746 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. © 1942 CAMBRIDGE UNIVERSITY PRESS1942 Article PDF first page preview Close Modal You do not currently have access to this content.
Determination of Intracellular pH by 31P Magnetic Resonance (1973)

Observation of the ^(31)P signal from various intracellular phosphates can provide a convenient, nondestructive technique for determining intracellular conditions such as pH. This procedure has been explored with particular reference to the erythrocyte. Both the chemical shift of intracellular inorganic phosphate relative to that of serum phosphate and the positions of, and more especially the difference between, the chemical shifts of 2,3-diphosphoglycerate have been used to monitor intracellular pH of erythrocytes whose hemoglobin has been liganded with carbon monoxide.
Synthesis of 1-oxa-2-oxocephalosporins (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of 1-oxa-2-oxocephalosporinsMatsuhiko Aratani, Daijiro Hagiwara, Hidekazu Takeno, Keiji Hemmi, and Masashi HashimotoCite this: J. Org. Chem. 1980, 45, 18, 3682–3686Publication Date (Print):August 1, 1980Publication History Published online1 May 2002Published inissue 1 August 1980https://pubs.acs.org/doi/10.1021/jo01306a028https://doi.org/10.1021/jo01306a028research-articleACS PublicationsRequest reuse permissionsArticle Views113Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Understanding data center traffic characteristics (2009)

As data centers become more and more central in Internet communications, both research and operations communities have begun to explore how to better design and manage them. In this paper, we present a preliminary empirical study of end-to-end traffic patterns in data center networks that can inform and help evaluate research and operational approaches. We analyze SNMP logs collected at 19 data centers to examine temporal and spatial variations in link loads and losses. We find that while links in the core are heavily utilized the ones closer to the edge observe a greater degree of loss. We then study packet traces collected at a small number of switches in one data center and find evidence of ON-OFF traffic behavior. Finally, we develop a framework that derives ON-OFF traffic parameters for data center traffic sources that best explain the SNMP data collected for the data center. We show that the framework can be used to evaluate data center traffic engineering approaches. We are also applying the framework to design network-level traffic generators for data centers.
Implementation of a new primality test (1987)

An implementation of the Cohen-Lenstra version of the Adleman-Pomerance-Rumely primality test is presented. Primality of prime numbers of up to 213 decimal digits can now routinely be proved within approximately ten minutes.
Pain, Disability, and Psychological Functioning in Chronic Low Back Pain Subgroups (1993)

A series of patients with chronic low back pain evaluated at a tertiary referral center were the subjects for this study. Of 250 consecutive patients, 94 were diagnosed as having myofascial pain and 57 as having herniated disc syndrome. Before evaluation and diagnosis, all patients completed the McGill Pain Questionnaire, ratings of pain and disability, and the Symptom Checklist 90-R. Patients were also grouped on the basis of previous surgical history and workers' compensation benefits. Patients suffering from myofascial pain were significantly less likely to report periods of pain relief than patients with herniated disc syndrome. Those receiving workers' compensation benefits reported significantly greater levels of pain, disability, and psychological distress than those not receiving benefits, irrespective of diagnosis. Patients who underwent previous surgery did not differ significantly from those who never underwent surgery. All patients had elevated scores on the Somatization subscale of the Symptom Checklist 90-R. Patients with myofascial pain and workers' compensation benefits demonstrated the highest levels of somatization and phobia. These findings suggest that the effects of low back pain of myofascial origin have comparable, if not worse, consequences than disc herniation. These findings also reaffirm the importance of workers' compensation in understanding the differences in patients with chronic low back pain.
Partitioning of Pyrene between “Crew Cut” Block Copolymer Micelles and H<sub>2</sub>O/DMF Solvent Mixtures (1997)

The effect of solvent composition on the partition coefficient (KV) of pyrene between the crew cut micelles formed from highly asymmetric block copolymers of polystyrene (500)-b-polyacrylic acid (60) and an H2O/DMF solvent mixture was studied using a fluorescence method. The total number of pyrene molecules incorporated per micelle was also determined as a function of polymer concentration and solvent composition. The relationship between the partition coefficient (KV) and the mass equilibrium constant (K) was obtained, and the free energy of transfer of pyrene from the solvent mixture to the micelle was calculated in terms of K. The results suggest that a gradual change in the solvent composition, which makes it increasingly incompatible with the solubilizate, may be a good method of loading hydrophobic materials into micelles.
Traffic Alert and Collision Avoidance System (TCAS) transition program (TTP): a status update (2002)

In response to United States (U.S.) law mandating installation, by December 31, 1993, of TCAS IT on all air carrier aircraft with more than thirty passenger seats operating in U.S. Airspace, the first in-service flight of a certified TCAS II production unit occurred in June 1990. Currently, worldwide installations of TCAS IT in air carrier and business aircraft are estimated at over 7,000 units. Total accumulated flight operations exceed 50 million hours, with over 1.5 million additional hours accumulated each month. This paper provides a status update on the TCAS Transition Program (TTP) which was established to monitor the operational performance and assist with the introduction of TCAS II avionics into the National Airspace System (NAS). The update is provided by means of a qualitative performance comparison between the software logic initially fielded (Version 6.02) and the latest version (Version 6.04A) developed to address various flight performance dynamics and interface issues between TCAS and the air traffic control (ATC) system. This latest software logic has been in operation in all TCAS II-equipped aircraft since January 1, 1995.
Preparation of basic yttrium carbonate for phosphate removal (1997)

Removal of phosphate ions from aqueous solutions has been studied with basic yttrium carbonate (BYC) of different compositions prepared by homogeneous precipitation with yttrium chloride and urea. Higher carbonate content was obtained with higher concentration of urea. Removal of phosphate was significant at pH less than 12 and dependent on the composition of BYC. The possible mechanism for removal is ion exchange with carbonate or hydroxide groups between pH 7 and 12 and through complex formation of phosphate with yttrium ions and ion exchange between pH 2 and 6. The phosphate adsorption capacity of BYC prepared with a higher concentration of urea was higher than that of BYC prepared with a lower urea concentration. The removal of phosphate followed a Langmuir model. The BYC of higher carbonate content gave higher percentage removal in the pH range of 6 to 11. The high phosphate adsorption capacity of the compound can be attributed to its carbonate group content and surface area. The phosphate adsorption was not affected by F − , SO 4 2− , NO 3 − , Br − , and I − in the basic pH range.
Termination of translation in eukaryotes (1995)

Termination of translation is governed in ribosomes by polypeptide chain release factors (pRF and eRF in prokaryotes and eukaryotes, respectively). In prokaryotes, three pRF have been indentified and sequenced, while in eukaryotes, only a single eRF has been identified to date. Recently, we have characterized a highly conserved protein family called eRF1. At least, human and Xenopus laevis proteins from this family are active as eRFs in the in vitro assay with any of the three stop codons. No structural similarity has been revealed between any of the three pRFs and eRF1 family. Furthermore, GTP-binding motifs have not been revealed, although translation termination in eukaryotes is a GTP-dependent process. We have demonstrated that in eukaryotes a second eRF exists in addition to eRF1, called eRF3. The eRF3 family has two features in common: presence of GTP-binding motifs and high conservation of the C-terminal domain structure. The C-terminal domain of the X. laevis eRF3 has no RF activity although it stimulates the eRF1 activity considerably at low concentration of the stop codons, conferring GTP dependence to the termination reaction. Without eRF3, the eRF1 activity is entirely GTP independent. Some features of X. laevis eRF3 (C-terminal domain) resemble those of pRF3. The newly identified eRF1 and eRF3 are structurally conserved and distinct from the respective pRF1/2 and pRF3 proteins, pointing to the possibility of different evolution of translation termination machinery in prokaryotes and eukaryotes. Bipartition of the translation termination apparatus probably provides high rate and accuracy of translation termination.
Mupirocin in polyethylene glycol base is not suitable for application to burns (1988)

Journal Article Mupirocin in polyethylene glycol base is not suitable for application to burns Get access E. B. KACZMARSKI E. B. KACZMARSKI Department of Microbiology, Withington HospitalNell Lane, Manchester, M20 8LR, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Antimicrobial Chemotherapy, Volume 22, Issue 5, November 1988, Page 771, https://doi.org/10.1093/jac/22.5.771 Published: 01 November 1988
Hydrogen Fluoride-Boron Trifluoride Extraction of Xylene Isomers (1950)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHydrogen Fluoride-Boron Trifluoride Extraction of Xylene IsomersD. A. McCaulay, B. H. Shoemaker, and A. P. LienCite this: Ind. Eng. Chem. 1950, 42, 10, 2103–2107Publication Date (Print):October 1, 1950Publication History Published online1 May 2002Published inissue 1 October 1950https://pubs.acs.org/doi/10.1021/ie50490a027https://doi.org/10.1021/ie50490a027research-articleACS PublicationsRequest reuse permissionsArticle Views177Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Wnt/β-Catenin–Promoted Macrophage Alternative Activation Contributes to Kidney Fibrosis (2017)

The Wnt/<i>β</i>-catenin pathway is crucial in normal development and throughout life, but aberrant activation of this pathway has been linked to kidney fibrosis, although the mechanisms involved remain incompletely determined. Here, we investigated the role of Wnt/<i>β</i>-catenin in regulating macrophage activation and the contribution thereof to kidney fibrosis. Treatment of macrophages with Wnt3a exacerbated IL-4- or TGF<i>β</i>1-induced macrophage alternative (M2) polarization and the phosphorylation and nuclear translocation of STAT3 <i>in vitro</i> Conversely, inhibition of Wnt/<i>β</i>-catenin signaling prevented these IL-4- or TGF<i>β</i>1-induced processes. In a mouse model, induced deletion of <i>β</i>-catenin in macrophages attenuated the fibrosis, macrophage accumulation, and M2 polarization observed in the kidneys of wild-type littermates after unilateral ureter obstruction. This study shows that activation of Wnt/<i>β</i>-catenin signaling promotes kidney fibrosis by stimulating macrophage M2 polarization.
Synthesis of Aliphatic Sulfenyl Halides Containing Ester Groups (1980)

Abstract A great number of aliphatic sulfenyl halides is known. Whereas many of them exhibit a halogen substituted alkyl residue, only few examples exist of such compounds containing a carbonyl or ester group as second functional group. All these compounds have been characterized by means of their addition products with olefins or phosphites, but none of them has been isolated as pure substance. In the case of the α-ketosulfenyl chlorides, the strong decomposition tendency makes the isolation (distillation) impossible1. The sulfenyl chlorides containing ester functions are reported to be stable for several
In Situ Generated Fireproof Gel Polymer Electrolyte with Li<sub>6.4</sub>Ga<sub>0.2</sub>La<sub>3</sub>Zr<sub>2</sub>O<sub>12</sub> As Initiator and Ion‐Conductive Filler (2019)

Abstract Poly(vinylidene fluoride‐ co ‐hexafluoropropylene) (PVDF‐HFP) based gel polymer electrolyte is regarded as a promising candidate to settle the safety issues of liquid electrolytes. However, the currently reported gel polymer electrolytes are still not safe enough owing to high amount of flammable liquid solvents contained in them. Herein, a fireproof PVDF‐HFP based gel polymer electrolyte is designed and synthesized through an in situ crosslinking method, with Li 6.4 Ga 0.2 La 3 Zr 2 O 12 as initiator and ion‐conductive filler. The obtained gel polymer electrolyte demonstrates superior fire resisting properties. The optimized gel polymer electrolyte exhibits an ionic conductivity as high as 1.84 × 10 −3 S cm −1 at 20 °C with an electrochemical window up to 4.75 V at room temperature. Moreover, the obtained gel polymer electrolyte shows excellent compatibility with lithium anodes. Therefore, the lithium anode is well protected. Lithium batteries assembled with the gel polymer electrolyte possess superb safety properties in cutting and burning tests. Furthermore, the batteries also show a discharge retention rate as high as 94.08% (in comparison with the initial discharge capacity) after cycling at 0.5 C for 360 cycles with an average columbic efficiency higher than 98%. The purpose of this report is to show the great potential of applying fire‐retardant gel polymer electrolyte to achieve high safety lithium batteries.
Simple Synthesis of 1,3,4,5a,6,10b,11,11a-Octahydro-2H-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole Derivatives Based on 1-Hydroxyindole Chemistry (2001)

The methanolic (MeOH) extract from the roots of Talinum paniculatum was found to exhibit inhibitory activities on the lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF)-α and nitric oxide (NO) production from mouse peritoneal macrophages, and on the TNF-α production from rat epididymal adipose tissue.From the MeOH extract, two new 8-benzyltetrahydroprotoberberine-type alkaloids, named javaberines A and B, were isolated and their structures were elucidated on the basis of chemical and physicochemical evidence.The principal alkaloid, javaberine A, inhibited LPS-induced TNF-α and NO production from mouse peritoneal macrophages and TNF-α production from rat epididymal adipose tissue.The Portulacaceae plant Talinum paniculatum GAERTNER, which is commonly called "Ginseng Java" or "Som Java" in Indonesia, is widely distributed in China, South Eastern Asia, and in South American countries.The roots of this plant are used as a tonic for men, a cure for pneumonitis, and for improving menostasia, while the fresh leaves are consumed as a vegetable.On the other hand, the roots of T. paniculatum are used for the treatment of neuralgia and arthritis in Brazil.Chemical constituents from the roots including higher alcohols (1-hexacosanol, 1-octacosanol, and 1-triacontanol), their acetates, sterols (campesterol, stigmasterol, and β-sitosterol), and β-sitosterol-glucoside were reported previously. 1 However, the pharmacologically active constituents of this natural medicine are left uncharacterized.As a part of our studies on tumor necrosis factor (TNF)-α and nitric oxide (NO) production inhibitors from natural medicines 2 and medicinal foodstuffs, 3 we found that the methanolic (MeOH) extract from the roots of T. paniculatum inhibited lipopolysaccharide (LPS)-induced TNF-α and NO production from
Forecasting incidence and issuing warnings for sugar beet leaf spot (Cercospora beticola Sacc.) in Yugoslavia. (1975)

Description of the identification of pigments using microscopic analysis. Techniques used for sampling are outlined and each type (cross-section, flakes, and powdered sample) is characterized. Size, transparency, association, homogeneity, colour and pleochroism, refractive index and other physical elements of pigments are described. A classification of pigments is given. Microchemical tests can also be used to confirm the microscopic identifications.