gebhart/patrepeval huggingface dataset:
Job Satisfaction And Stress Of Home Economics Teachers (1987)

The purpose of this study was to investigate the relationship between (1) job satisfaction and stress, (2) job satisfaction and nine demographic variables, and (3) stress and nine demographic variables in secondary home economics teachers. Questionnaires, including a teacher profile, the short form of the Min nesota Satisfaction Questionnaire, and the New York State Teachers Survey on Teacher Stress, were mailed to 150 teachers. Respondents included 100 currently employed consumer, homemaking, and occupational home economics teachers. No relationship was found between stress and job satisfaction nor between stress and any demographic variables. Significant differences in job satisfaction were found for the demographic variables of number of pupils taught, years as a teacher, and marital status. Intrinsic satisfaction was significantly associated with number of pupils, years as teacher, and type of school system while extrinsic satisfaction was significantly associated with marital status and number of pupils. Discussion includes possible explanations for findings and implications for teachers and teacher educators.
Percutaneous Radiofrequency Ablation of Inoperable Primary Lung Cancer (2004)

Purpose: To present the initial experience of percutaneous radiofrequency ablation (RFA) of inoperable primary lung cancer, and to assess the technical feasibility and potential complications. Materials and Methods: Twenty patients with inoperable lung cancer underwent percutaneous RFA. Nineteen of 20 patients had stage III or IV non-small cell lung cancer, and the remaining one had stage I lung cancer with pulmonary dysfunction. The mean tumor size was 4.60.4 cm (range, 1.8-8.4 cm). RFA was performed with a single (n=18) or cluster (n=2) cool-tip RF electrode and a generator under CT guidance using local anesthesia and conscious sedation. Twenty tumors were treated in 28 sessions. Patients were assessed by contrastenhanced CT in all cases at 1 week, 1 month, and 3 months. Eleven patients received chemotherapy (n=10) or radiotherapy (n=1) after RFA. Results: RFA was technically successful and well tolerated in all patients. Complete necrosis was attained in 7 lesions (35%), near complete (90-99%) necrosis in 10 lesions (50%), and partial (50-89%) necrosis in 3 lesions (15%). During the mean follow up of 202 days (21 to 481 days), tumor size was decreased in 13 patients, unchanged in 3, and increased in 4. In the latter four, additional RFA was performed. One patient underwent surgery three months after RFA and the histopathologic findings showed a large cavity with thin fibrotic wall suggestive of complete necrosis. During or after the procedure, pneumothorax (n=10), moderate pain (n=4), blood tinged sputum (n=2), and pneumonia (n=2) were developed. Chest tube drainage was required in only 1 patient due to severe pneumothorax. Other patients were managed conservatively. Seven patients died at 61 to 398 days (mean, 230 days) after RFA. The remaining 13 patients were alive 21 to 481 days (mean, 187 days) after RFA. Conclusion: RFA appears to be a technically feasible and relatively safe procedure for the cytoreductive treatment of inoperable, non-small cell lung cancer and warrants further investigation as a complementary treatment to chemotherapy or radiation therapy.
An ASIC library granular DRAM macro with built-in self test (2002)

System-on-a-chip architectures are generating increased interest as the level of integration is expanded by the arrival of 0.25 /spl mu/m processes. Many merged DRAM and logic applications use custom logic circuits that either surround or are embedded in a DRAM core. A more classic ASIC library approach where a DRAM macro family is used as a logic building block with the software tools associated with ASIC logic macros: i.e., timing analysis, place-and-route, logic simulation, and test generation. The macro operation is generic, yet versatile, allowing gate-array or standard-cell interface personalization. The design has a wide databit interface of 128 or 256 bits, separate databit-in and databit-out to ease bus contention, bit-write capability for multiplexing to narrower databit widths or partial databit-writes, and granular-density options from 0.5 Mb-8 Mb. Built-in self test (BIST) with two-dimensional redundancy calculation and allocation, along with in-situ burn-in capability, is also included. The DRAM macro design is architectured for reuse on future DRAM-generation sub-arrays and is adaptable to any number of address or databit-pin configurations. Its methodology and functionality have been verified in a 0.45 /spl mu/m trench DRAM technology.
Auditory processing disorders (2003)

In Brief A review of auditory processing disorders in adults: how to diagnose them, why they matter, and strategies for managing them. Teri James Bellis
Fabrication of coupled mode photonic devices in glass by nonlinear femtosecond laser materials processing (2002)

Coupled mode devices are fabricated in transparent glasses by nonlinear materials processing with femtosecond laser pulses. Using the direct output of an extended cavity femtosecond laser, without the need for a laser amplifier, single mode waveguides can be rapidly fabricated with well controlled parameters. A variety of photonic waveguide devices are demonstrated. Directional couplers with various interaction lengths and coupling coefficients are fabricated and their coupling properties are characterized. Measurements demonstrate coupled mode behavior consistent with theory. An unbalanced Mach-Zehnder interferometer is also fabricated and demonstrated as a spectral filter.
A digital adaptive filter using a memory-accumulator architecture: Theory and realization (1983)

This paper presents a novel approach to the construction of an adaptive filter making use of the so-called "distributed arithmetic" filter architecture originally suggested by Peled and Liu [7] for the realization of fixed response digital frequency filters. The technique uses only the operations of memory access, addition, and scaling, without the need for digital multiplication. Since multiplication is often quoted as the major bottleneck in digital signal processing structures, the system derives considerable advantage by the exclusion of this operation. The paper presents the derivation of a new adaptive algorithm based on this particular hardware structure, although no rigorous theoretical proof of the algorithm convergence properties is given. Computer simulations are included to demonstrate some of the basic operational characteristics of the structure. Finally, results from a hardware prototype, constructed using standard TTL integrated circuits, are presented. This approach differs from contemporary ideas which depend on the use of digital multipliers in either custom VLSI designs or using standard signal processing chips. It offers high-bandwidth operation at low cost using devices which are already in great demand by the computer market. Alternatively, the algorithm is ideal for implementation as a microprocessor-based system which could operate on real-time voice-bandwidth signals with a minimum of peripheral interface circuitry.
An explanation facility for today's expert systems (1989)

The authors discuss explanation facility types found in most expert systems and shells used today, referring to these as practice systems, since they represent current practice in expert system work. Practice systems include nonresearch expert systems (being developed every day in industry) as well as nonresearch expert system shells. They maintain that an extensive explanation facility meeting the obligations of a practice system's role can be implemented using only practice technology. They discuss the relationship of journalism to explanation, showing that explanation facility tasks (roles) on current practice expert systems and shells resemble a newswriter's tasks, as both involve presenting users or readers with accurate, objective, noninteractive accounts of events. In news reporting, events are pieces of news. In expert-system explanation, events are actions taken by expert systems. The authors present a journalistic explanation facility, Joe, which is part of AGNESS (a generalized network-based expert system shell), under development at the University of Minnesota.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Selective cytotoxicity of EFG labeled liposomes encapsulating bleomycin for A431 cells. (1993)

EGF-labeled reverse phase evaporation vesicles (EGF-REV) encapsulating bleomycin (BLM) have been prepared and their selective uptake and cytotoxic activity have been evaluated using A431 and Swiss/3T3 cells which are over-expressing EGF-receptors on cell surface and no EGF-receptor, respectively. EGF has been bound to REV surface as active form, and EGF-REV has been taken up selectively by A431 cells via EGF-receptors, but not by Swiss/3T3 cells. Cytotoxic activity of EGF-REV encapsulating BLM (EGF-REV-BLM) for A431 cells was superior to that of normal liposomes containing BLM, and this effect was dependent on the treatment time. However, this cytotoxic activity of EGF-REV-BLM could not be observed in Swiss/3T3 cells, These findings suggested that EGF-REV is a useful drug carrier for squamous carcinoma which are over-expressing EGF-receptors on cell surface.
2-Arachidonoylglycerol Reduces Proteoglycans and Enhances Remyelination in a Progressive Model of Demyelination (2017)

The failure to undergo remyelination is a critical impediment to recovery in multiple sclerosis. Chondroitin sulfate proteoglycans (CSPGs) accumulate at demyelinating lesions creating a nonpermissive environment that impairs axon regeneration and remyelination. Here, we reveal a new role for 2-arachidonoylglycerol (2-AG), the major CNS endocannabinoid, in the modulation of CSPGs deposition in a progressive model of multiple sclerosis, the Theiler's murine encephalomyelitis virus-induced demyelinating disease. Treatment with a potent reversible inhibitor of the enzyme monoacylglycerol lipase, which accounts for 85% of the 2-AG degradation in the mouse CNS, modulates neuroinflammation and reduces CSPGs accumulation and astrogliosis around demyelinated lesions in the spinal cord of Theiler's murine encephalomyelitis virus-infected mice. Inhibition of 2-AG hydrolysis augments the number of mature oligodendrocytes and increases MBP, leading to remyelination and functional recovery of mice. Our findings establish a mechanism for 2-AG promotion of remyelination with implications in axonal repair in CNS demyelinating pathologies.<b>SIGNIFICANCE STATEMENT</b> The deposition of chondroitin sulfate proteoglycans contributes to the failure in remyelination associated with multiple sclerosis. Here we unveil a new role for 2-arachidonoylglycerol, the major CNS endocannabinoid, in the modulation of chondroitin sulfate proteoglycan accumulation in Theiler's murine encephalomyelitis virus-induced demyelinating disease. The treatment during the chronic phase with a potent reversible inhibitor of the enzyme monoacylglycerol lipase, which accounts for 85% of the 2-arachidonoylglycerol degradation in the mouse CNS, modulates neuroinflammation and reduces chondroitin sulfate proteoglycan deposition around demyelinated lesions in the spinal cord of Theiler's murine encephalomyelitis virus-infected mice. The increased 2-arachidonoylglycerol tone promotes remyelination in a model of progressive multiple sclerosis ameliorating motor dysfunction.
Toward the Introduction of New Materials and Structural Changes to Improve MOSFET Performance (2005)

SUMMARY AND CONCLUSIONS Scaling CMOS to and beyond the 22-nm technology node(requiring a physical gate length of 9-nm or less) will probablyrequire the introduction of several new material and struc-tural changes to the MOSFET to sustain performance increas-es of 17% per year and to manage SCEs. Material changes willinclude strained silicon n- and p-channels and a new gatestack including a high-k dielectric and a metal gate electrode.Structural changes could include fully depleted UTB SOI sin-gle-gate MOSFETs, perhaps followed by fully depleted UTBdouble-gate structures. Attaining the performance require-ments for the final node for high performance applicationscould further require channels providing quasiballistic carriertransport, or very low-resistance source/drain contacts provid-ed by Schottky metal electrodes. The materials and structuralchanges actually introduced to advanced process technologieswill depend both on their readiness for manufacture and theirvalue in improving performance in the ultra-scaled devices.For example, a high-
sin 1, a mutation affecting female fertility in Arabidopsis, interacts with mod 1, its recessive modifier. (1994)

In Arabidopsis thaliana, a mutation in the SIN 1 gene causes aberrant ovule development and female-specific sterility. The effect of the sin 1 mutation is polymorphic and pleiotropic in different genetic backgrounds. The polymorphism concerns morphology of the mutant ovules. The pleiotropism involves internodal distance and inflorescence initiation time. The particular ovule phenotype and the length of internodes are dependent on an interaction of sin 1 with a second recessive gene, which we term mod 1. The recessive mod 1 allele in a homozygous sin 1 mutant plant reduces internode length and ovule integument size. The mutation sin 1, but not mod 1, has a demonstrable effect on ovule morphology when acting independently. In our crosses mod 1 was inseparably linked to the well known mutation erecta that is known to cause a reduction in internode and pedicle lengths.
Gene inactivation in Lec35.1 (mannosylation-defective) Chinese hamster ovary cells. A cautionary note. (1993)

In Lec35.1 CHO mutants, mannose-P-dolichol is synthesized but does not participate in the production of glycosylphosphatidylinositol (GPI) anchor precursors or dolichol-linked oligosaccharides. We tested Lec35.1 cells for stable expression of a cDNA encoding GPI-anchored human folate-binding protein (FBP) with the eukaryotic expression vector pJB20. All normal transfectants, but no Lec35.1 transfectants, expressed FBP activity. However, rather than an inability to produce GPI anchors, lack of FBP expression in Lec35.1 was caused by gradual inactivation of the FBP cDNA. FBP cDNA became fully inactive after 2-3 months of culture, and FBP activity was not restored upon correction of the Lec35 mutation. Southern blot analysis revealed that inactivation was associated with gross rearrangement of FBP cDNA. The cellular FBP gene remained intact. Because the Lec35.1 cell line has the ability to inactivate transfected human FBP cDNA, caution should be exercised when expressing transfected cDNAs in Lec35.1 and similar GPI anchor/glycosylation mutants. Interestingly, these results suggest similarities between the Lec35.1 defect and the human disease paroxysmal nocturnal hemoglobinuria, which may involve gradual inactivation of a gene necessary for mannosylation of GPI anchor precursors.
Analysis of the binding sites of chromium to DNA and protein <i>in vitro</i> and in intact cells (1992)

Previous studies have examined Cr(III), or CrO4 reduced to Cr(III), binding in vitro to DNA. However, there have been few studies examining chromate binding to DNA in intact cells. Treatment of intact cells with chromate (Na2(51)CrO4) resulted in chromium (Cr) binding to DNA. The binding of Cr to DNA was much more stable when more residual peptide/amino acids were associated with DNA. A substantial portion of the Cr bound to DNA was released by treatment with EDTA, suggesting that trivalent Cr was the major oxidation state of Cr bound to DNA. Cr(III) stimulated the formation of amino acid-DNA and protein-DNA complexes in vitro. Tyrosine and cysteine exhibited the highest activity in being complexed to DNA by Cr(III) in vitro, while histidine, methionine and threonine also exhibited more activity than any other amino acid. Similar results were found in intact cells. The activity of proteins complexed to DNA by trivalent Cr depended upon the content of these reactive amino acids. Thus, bovine serum albumin was more active than actin, which in turn was more active than histones. These and other studies presented suggested that Cr(III) was involved directly in the formation of DNA-protein complexes in intact cells, unlike other metals such as Ni(II), which are thought to form DNA-protein cross-links catalytically and not participate directly in the complex. The majority of trivalent Cr associated with DNA was bound to the phosphate backbone without exhibiting any base specificity. Collectively, these results indicate that trivalent Cr creates DNA protein crosslinks by binding with reactive amino acids (i.e. cysteine, tyrosine or histidine) and linking these to the phosphate backbone of DNA.
Measuring photodarkening from single-mode ytterbium doped silica fibers (2006)

Photodarkening is recognized as a potentially important limiting factor on the lifetime and reliability of many Yb-doped fiber lasers and amplifiers. In particular, a photodarkening process attributed to the formation of photoinduced structural transformations can induce excess loss in the doped glass core of the fiber, resulting in reduced output power efficiency. Yet, quantifiable measurement techniques of this phenomenon have been scarce in the literature to date. Here we present a fast, simple and repeatable method to measure and compare the photodarkening rate caused by the formation of photoinduced structural transformations from Yb-doped single-mode fibers. The method relies on quantifying observations of transmission changes at visible wavelengths as an indicative measure of photodarkening at the signal wavelengths. Preliminary measurement results are presented supporting the utility of the technique for benchmarking the photodarkening behavior of different Yb-doped fibers.
Thrombin-Catalyzed Activation of Recombinant Human Factor V (1995)

Proteolytic activation of human factor V by thrombin results from the cleavage of three peptide bonds at Arg709, Arg1018, and Arg1545. In order to define the functional importance of these sites, mutants with isoleucine substitutions blocking thrombin cleavage at one, two, or all three activation sites were expressed in COS-7 cells. The wild type protein is activated approximately 10-fold by thrombin or Russell's viper venom (RVV-V). Thrombin cleavage at Arg709 alone did not result in an increase in procoagulant activity. Cleavage at both Arg709 and Arg1018 resulted in an approximately 3.4-fold increase in activity. Cleavage at these sites was required for rapid cleavage by thrombin at Arg1545, however, which resulted in maximal activation of the factor V molecule. In contrast, isolated cleavage at Arg1545 by RVV-V was sufficient for efficient and complete activation of factor V. The effect of isoleucine substitutions at one or both thrombin cleavage sites in a B-domain deletion mutant lacking amino acids 811-1491 was also investigated. The specific activity of all four mutants was approximately 30% compared to thrombin activated factor V, indicating that these isoleucine substitutions do not drastically alter the structure of the protein and that cleavage at these sites is not required for the expression of partial procoagulant activity.
Application of the indirect tube LAI assay in the study of cell-mediated immunity in rats immunized with B77 tumor cells. (1980)

The indirect tube LAI (leukocyte adherence inhibition) test has revealed that peripheral blood lymphocytes of rats of the inbred Lewis strain immunized with liver B77 tumor cells incubated in the presence of a specific tumor extract, release a factor into the culture medium that inhibits adherence of normal syngeneic peritoneal cells. Supernatants in which lymphocytes of healthy - control animals had been incubated in the presence of the same extract (B77), or lymphocytes of immunized donors incubated in the presence of another type of tumor extract (MC-1) were devoid of such a property. This soluble factor was found in the supernatants only after 20 hours of incubation of sensibilized lymphocytes with a specific tumor extract. Th percentage of adhering cells decreased in dependence on the concentration of the soluble factor. The results are discussed in connection with questions relevant to the mechanism of LAI reactivity and the application of this phenomenon in studies on cell immunity.
SLIM (1985)

SLIM (Stanford Language for Implementing Microcode) is a programming language based system for specifying and simulating microcode in a VLSI chip. The language is oriented towards PLA implementations of microcoded machines using either a microprogram counter or a finite state machine. The SLIM system supports simulation of the microcode and will drive a PLA layout program to automatically create the PLA.
Stability analysis of multivariable predictive control - a polynomial approach (2001)

A rigorous method for analyzing the stability and performance of unconstrained multivariable predictive controllers is developed using polynomial operators and coprime matrix factorizations. The stability of the closed-loop systems is assessed in terms of two characteristic equations that define the system poles. It is also shown that a closed-loop stable predictive controller delivers offset free tracking for a set of plants satisfying specific conditions. The large number of prediction and control horizons that can be specified complicates the tuning of predictive controllers; however, the task is facilitated with the aid of the tools presented here because unstable horizon selections can be identified and rejected. The analysis approach is illustrated with an example.
Treatment of complications due to peritoneal dialysis for chronic renal failure with traditional Chinese medicine. (1999)

In this paper, the experience in the treatment of complications due to continuous ambulatory peritoneal dialysis for chronic renal failure with traditional Chinese medicine (TCM) is reported. Modified Renshen Yangrong Tang (Ginseng Nutrition Decoction) was used for anorexia and hypoproteinemia; modified Xiangsha Liujunzi Tang (Decoction of Cyperus and Amomum with Six Noble Ingredients) for abdominal pain and distension; modified Da Chaihu Tang (Major Bupleurum Decoction) for peritonitis; modified Shenling Baizhu San (Powder of Ginseng, Poria and Atractylodes) for diarrhea due to insufficiency of the spleen with abundance of dampness; Lizhong Tang (Decoction for Regulating the Function of Middle-jiao) and modified Sishen Wan (Pills of Four Miraculous Drugs) for insufficiency of both the spleen and the kidney; Siwu Tang (Decoction of Four Ingredients) added with other drugs for cutaneous pruritus, and Guishao Sijunzi Tang (Decoction of Four Noble Drugs added with Chinese Angelica Root and white Peony Root) for renal anemia. The therapeutic principles of invigorating the liver and kidney, strengthening the bones and muscles, and promoting blood circulation to eliminate blood stasis were adopted in the treatment of renal osteopathy, and the therapeutic principles of invigorating the liver and kidney, expelling phlegm and resolving dampness, and promoting blood circulation to eliminate blood stasis in the treatment of hyperlipemia. Shen Tekang capsules (capsules for improving the renal function) was administered to patients for strengthening the viability and improving the nutrition state, and the recipe for treating renal function failure (both formulated by the authors) for improving the renal function so as to decrease the frequency and duration of dialysis.