gebhart/patrepeval huggingface dataset:
PMD compensation in 10 Gbit/s NRZ field experimentusing polarimetric error signal (2000)

A technique for compensating for the polarisation mode dispersion of a 10 Gbit/s non-return to zero (NRZ) installed fibre link (45 km, 80 ps mean differential group delay), using a variable polarisation delay line and a set of polarisation controllers is presented. The variation of the output polarisation with frequency over the signal bandwidth was monitored using a frequency-resolving Stokes-polarimeter. A control loop is used to minimise the RMS deviation of the polarisation state at the receiver.
Microdilution Technique for Antimicrobial Susceptibility Testing of Anaerobic Bacteria (1975)

A microdilution technique using commercially available media and materials was developed and used to determine the minimal inhibitory concentrations (MICs) of clindamycin, chloramphenicol, tetracycline, minocycline, ampicillin, carbenicillin, cephalothin, and gentamicin for 101 anaerobic isolates. Representative strains of Bacteroides, Clostridium, Fusobacterium, Peptococcus, and Peptostreptococcus were tested. The use of Schaedler broth at pH 7.2, an inoculum of 10(5) to 10(7) colony-forming units per ml, and incubation at 35 C in an anaerobic glove box with an atmosphere of 80% nitrogen, 10% hydrogen, and 10% carbon dioxide resulted in good growth and easily interpretable results. After 48 h of incubation, 97% of strains tested were inhibited by 3.1 mug or less of clindamycin per ml and 98% were inhibited by 12.5 mug or less of chloramphenicol per ml. Tetracycline and minocycline inhibited 81 and 88% of strains tested in concentrations of 1.6 mug or less per ml and 1.6 mug or less per ml, respectively. Ampicillin inhibited all strains other than B. fragilis in concentrations of 3.1 mug or less per ml. Excluding certain strains of Bacteroides and Clostridium, carbenicillin in concentrations of 12.5 mug or less per ml and cephalothin in concentrations of 6.2 mug or less per ml inhibited all strains tested. Gentamicin was inactive although some strains of anaerobic cocci and Bacteroides were inhibited by 3.1 mug or less per ml. After 18 to 24 h of incubation, eight of the 101 strains had not grown sufficiently for MICs to be determined; for the 93 strains which had grown sufficiently, 93% of 744 MICs were the same or one concentration lower than the 48-h MICs.
Potential early markers of Parkinson disease in idiopathic REM sleep behavior disorder (2006)

Many potential early markers of Parkinson disease are significantly abnormal in idiopathic REM sleep behavior disorder. These abnormalities are present in approximately half of the patients, suggesting a heterogenous pathophysiology.
Analysis and Detection of Content based Video Retrieval (2019)

Based Video Retrieval (CBVR) System has been investigated over past decade it's rooted in many applications like developments and technologies.
Isolement et Synthese de l'Espintanol, Nouveau Monoterpene Antiparasitaire (1991)

The in vitro leishmanicidal and trypanocidal activities of a petroleum ether extract of Oxandra espintana have been investigated. Four aromatic monoterpenes were isolated, of which two are novel: espintanol [3a], responsible for the antiparasite activity, and O-methylespintanol [4]. Espintanol was tested in vitro on 20 strains of Trypanosoma cruzi and 12 strains of Leishmania spp. Its structure was determined by spectroscopic methods and confirmed by its preparation starting from carvacrol.
Onboard System Provides Stability, Mooring, and Motion Analysis for Semisubmersible Drilling Operations (1988)

Summary Vessel stability, mooring, and motion-related decisions on semisubmersible drillships have historically been made with a combination of the marine crew's experience and guidelines documented in the ship's operating manual. This is especially true once the vessel is on location and operations are under way. This situation leaves the operator dependent on contractors to anticipate problems and to take correct remedial action. This paper presents a computer system that combines state-of-the-art marine technology with a simple user interface to provide information useful to operations personnel in making decisions. The purpose of the system is not to take over any of the contractors' responsibilities. It does provide additional information useful in making marine-related decisions. This allows the contractor and the operator to combine experience and analysis and work toward a mutual decision. This tool, referred to as the "Onboard System," was used by drilling personnel on two semisubmersibles in the Bering Sea. In addition to stability, mooring, and motion capabilities, the Onboard System provides a data base of environmental information and corresponding vessel responses while on location.
Cell cycle checkpoint signaling involved in histone deacetylase inhibition and radiation-induced cell death (2005)

In breast cancer, radiation has a central role in the treatment of brain metastasis, although tumor sensitivity might be limited. The tumor cell defense response to ionizing radiation involves activation of cell cycle checkpoint signaling. Histone deacetylase (HDAC) inhibitors, agents that cause hyperacetylation of histone proteins and thereby aberrations in the chromatin structure, may also override the DNA damage defense response and facilitate the radiation-induced mitotic cell death. In experimental metastasis models, the human breast carcinoma cell line MA-11 invariably disseminates to the central nervous system. We compared profiles of in vitro MA-11 cell cycle response to ionizing radiation and HDAC inhibition. After radiation exposure, the G2-M phase accumulation and the preceding repression of the G2 phase regulatory factors Polo-like kinase-1 and cyclin B1 required intact G2 checkpoint signaling through the checkpoint kinase CHK1, whereas the similar phenotypic changes observed with HDAC inhibition did not. MA-11 cells did not show radiation-induced expression of the G1 cell cycle inhibitor p21, indicative of a defective G1 checkpoint and consistent with a point mutation detected in the tumor suppressor TP53 gene. Increase in the p21 level, however, was observed with HDAC inhibition. Following pretreatment with the HDAC inhibitor, the efficiency of clonogenic regrowth after irradiation was reduced, which is in accordance with the concept of increased probability of mitotic cell death when the chromatin structure is disrupted. Among molecular cell cycle-targeted drugs currently in the pipeline for testing in early-phase clinical trials, HDAC inhibitors may have therapeutic potential as radiosensitizers.
Different biochemical modes of action of two irreversible H+,K(+)-ATPase inhibitors, omeprazole and E3810. (1993)

Omeprazole and E3810 were found to inhibit gastric H+,K(+)-ATPase following different biochemical mechanisms. Effects of the specific binding of the inhibitors on the conformational state of the enzyme were studied by measuring the fluorescence of the enzyme labeled with fluorescein 5'-isothiocyanate. The absolute fluorescence level of the omeprazole-bound enzyme was lower than that of the control enzyme, and reduction of S-S cross-linking between the enzyme and omeprazole increased the fluorescence. Addition of K+ into the control vesicle solution quenched the fluorescence (E1-->E2K+). The quench was inhibited in the omeprazole-bound enzyme but not in the E3810-bound enzyme. These results suggest that the omeprazole-bound enzyme has a low fluorescence conformation (E2 form). On the other hand, the conformation of the E3810-bound enzyme was the same as that of the control enzyme (E1 form). Phosphoenzyme formation in the absence of K+ was inhibited in both the E3810- and omeprazole-bound enzymes. Binding of 2',3'-o-(2,4,6-trinitrophenyl)adenosine 5'-triphosphate to the enzyme was equally inhibited by E3810 and omeprazole. K(+)-dependent dephosphorylation from the phosphoenzyme was inhibited in the E3810-bound enzyme but not in the omeprazole-bound enzyme. These experimental results have shown that the inhibition mechanism of H+,K(+)-ATPase by omeprazole was different from that by E3810; the partial reaction that was the most differently affected by the inhibitors was the conformational change from the E2 to E1 form for omeprazole and the luminal K(+)-dependent dephosphorylation for E3810.
Minimizing information leakage in the DNS (2008)

The domain name system is the global lookup service for network resources. To protect DNS information, the DNS security extensions have been developed and deployed on branches of the DNS to provide authentication and integrity protection using digital signatures. However, signed DNS nodes were found to have an unfortunate side effect: an attacker can query them as reconnaissance before attacking hosts on a particular network. There are different ways a zone administrator can minimize information leakage and still take advantage of DNSSEC for integrity and source authentication. This article describes the risk and examines the protocol and operational options and looks at their advantages and drawbacks.
Void Distribution and Fluid Flow in Packed Bed (1993)

The X-ray computed tomography method was applied to visualization of the interior of a packed bed reactor. It takes only a few minutes to obtain a radial and vertical two-dimensional profile of the local bed porosity, while the ordinary technique obtains only a one-dimensional radial porosity profile. It is well known that the channeling flow near the wall of bed packed with relatively large particles happens due to the local high porosity. To examine whether the channeling flow happens in a catalyst bed, velocity profiles in the packed bed were simulated with the two-dimensional porosity profiles obtained by the X-ray computed tomography.
Synthesis and Chemiluminescence of Coelenterazine (<i>Oplophorus</i> Luciferin) Analogues (1990)

Abstract In the case of chemiluminescence of coelenterazine, effects of conformation rigidity of and hydrogen bonding with the emitter, coelenteramide, on the chemiluminescence efficiency have been examined with several coelenterazine analogues synthesized. Conformational rigidity has a light enhancing effect, whereas decreasing light yield was observed by hydrogen-bond formation with the emitter.
Treatment of chronic antibody mediated rejection with intravenous immunoglobulins and rituximab: A multicenter, prospective, randomized, double-blind clinical trial (2017)

There are no approved treatments for chronic antibody mediated rejection (ABMR). We conducted a multicenter, prospective, randomized, placebo-controlled, double-blind clinical trial to evaluate efficacy and safety of intravenous immunoglobulins (IVIG) combined with rituximab (RTX) (EudraCT 2010-023746-67). Patients with transplant glomerulopathy and anti-HLA donor-specific antibodies (DSA) were eligible. Patients with estimated glomerular filtration rate (eGFR) <20 mL/min per 1.73m<sup>2</sup> and/or severe interstitial fibrosis/tubular atrophy were excluded. Patients were randomized to receive IVIG (4 doses of 0.5 g/kg) and RTX (375 mg/m<sup>2</sup> ) or a wrapped isovolumetric saline infusion. Primary efficacy variable was the decline of eGFR at one year. Secondary efficacy variables included evolution of proteinuria, renal lesions, and DSA at 1 year. The planned sample size was 25 patients per group. During 2012-2015, 25 patients were randomized (13 to the treatment and 12 to the placebo group). The planned patient enrollment was not achieved because of budgetary constraints and slow patient recruitment. There were no differences between the treatment and placebo groups in eGFR decline (-4.2 ± 14.4 vs. -6.6 ± 12.0 mL/min per 1.73 m<sup>2</sup> , P-value = .475), increase of proteinuria (+0.9 ± 2.1 vs. +0.9 ± 2.1 g/day, P-value = .378), Banff scores at one year and MFI of the immunodominant DSA. Safety was similar between groups. These data suggest that the combination of IVIG and RTX is not useful in patients displaying transplant glomerulopathy and DSA.
Design oriented analysis of a high power factor and low cost three-phase rectifier (2002)

The analysis of a new three-phase rectifier with high power factor is presented in this paper, in view of a complete design procedure. The main features of the proposed circuit are low cost, small size, high efficiency and simplicity. With the introduction of the "critical inductance" of the converter, the circuit can be analyzed by a simplified equivalent circuit. A set of linear equations was derived, modeling the input current of the rectifier and demonstrating the high power factor and low harmonic distortion characteristics of the circuit. The theoretical analysis was validated with simulation and experimental results obtained from two laboratory prototypes rated at 7 kW and 12 kW, connected to the 220 V, 60 Hz AC system.
<scp>l</scp> -CYSTINE REQUIREMENT FOR PRODUCTION OF COXSACKIE B3 VIRUS IN CULTURED MONKEY HEART CELLS (1963)

Tyndall, R. L. (The Pennsylvania State University, University Park) and E. H. Ludwig. l-Cystine requirement for production of Coxsackie B3 virus in cultured monkey heart cells. J. Bacteriol. 85:1339-1345. 1963.-The requirement for l-cystine in both the production of Coxsackie B3 virus in cultured monkey heart cells and in prolonging the survival of the cultured monkey heart cells is demonstrated. d-Cystine, dl-homocystine, dl-allo-cystathionine, dl-homocysteine thiolactone, 2-mercaptoethlyamine, allylglycine, 3,3'-dithiopropionic acid, and dl-ethionine could not replace l-cystine in either supporting Coxsackie B3 virus production or prolonging monkey heart cell culture survival time. By their ineffectiveness, these compounds suggest the specificity of the l-cystine requirement. Allylglycine, 3,3'-dithiopropionic acid, and dl-ethionine were likewise incapable of inhibiting the l-cystine effect in supporting both virus production and cell survival. Prolonged starvation of cell cultures prior to virus inoculation failed to reveal any additional marked nutritional requirements, but rather tended to accentuate the l-cystine requirement for virus production. Increased cell starvation did, however, lead to the establishment of a latent Coxsackie B3 virus infection of cultured monkey heart cells, the activation of which is l-cystine-dependent.
Multileaf collimator end leaf leakage: implications for wide-field IMRT (2007)

The multi-leaf collimator (MLC) of a particular linear accelerator vendor (Millennium MLC, Varian Medical Systems, Palo Alto, CA, USA) has a maximum leaf extension of 14.5 cm. To achieve intensity modulated radiotherapy (IMRT) for fields wider than 14.5 cm all closed leaf pairs are restricted to placement inside the field. Due to the rounded leaf end design of the MLC end leaf leakage will occur in the treatment field. The implementation of direct aperture optimization in the IMRT module of a radiotherapy treatment planning system (Pinnacle, Philips Radiation Oncology Systems, Milpitas, CA) has facilitated the delivery of IMRT fields wider than 14.5 cm. The end leaf leakage of the Millennium MLC has been characterized for 6 MV photons using gafchromic and radiographic film, and the accuracy of the planning system verified. The maximum leakage measured for a single field was 0.39 cGy MU(-1) for a 0 mm leaf gap and 0.51 cGy MU(-1) for a 0.6 mm leaf gap. For a clinical IMRT field leaf end leakage contributed an additional 2-3 Gy over the course of treatment. The planning system underestimated the magnitude of end leaf leakage by 20-40%. The ability to deliver IMRT fields wider than 14.5 cm with the Millennium MLC has improved the efficiency and flexibility of IMRT treatments; however, significant extra dose can be introduced due to end leaf leakage. Caution should be exercised when delivering wide field IMRT as it is not a complete panacea. Any significant occurrences of end leaf leakage predicted by the planning system should be independently verified prior to delivery.
X1000 real-time phoneme recognition VLSI using feed-forward deep neural networks (2014)

Deep neural networks show very good performance in phoneme and speech recognition applications when compared to previously used GMM (Gaussian Mixture Model)-based ones. However, efficient implementation of deep neural networks is difficult because the network size needs to be very large when high recognition accuracy is demanded. In this work, we develop a digital VLSI for phoneme recognition using deep neural networks and assess the design in terms of throughput, chip size, and power consumption. The developed VLSI employs a fixed-point optimization method that only uses +Δ, 0, and -Δ for representing each of the weight. The design employs 1,024 simple processing units in each layer, which however can be scaled easily according to the needed throughput, and the throughput of the architecture varies from 62.5 to 1,000 times of the real-time processing speed.
Tree-oriented interactive processing with an application to theorem-proving, appendix E (1985)

The concept of unstructured structure editing and ted, an editor for unstructured trees, is described. Ted is used to manipulate hierarchies of information in an unrestricted manner. The tool was implemented and applied to the problem of organizing formal proofs. As a proof management tool, it maintains the validity of a proof and its constituent lemmas independently from the methods used to validate the proof. It includes an adaptable interface which may be used to invoke theorem provers and other aids to proof construction. Using ted, a user may construct, maintain, and verify formal proofs using a variety of theorem provers, proof checkers, and formatters.
Bayesian Object Detection in Dynamic Scenes (2005)

Detecting moving objects using stationary cameras is an important precursor to many activity recognition, object recognition and tracking algorithms. In this paper, three innovations are presented over existing approaches. Firstly, the model of the intensities of image pixels as independently distributed random variables is challenged and it is asserted that useful correlation exists in the intensities of spatially proximal pixels. This correlation is exploited to sustain high levels of detection accuracy in the presence of nominal camera motion and dynamic textures. By using a non-parametric density estimation method over a joint domain-range representation of image pixels, multi-modal spatial uncertainties and complex dependencies between the domain (location) and range (color) are directly modeled. Secondly, temporal persistence is proposed as a detection criteria. Unlike previous approaches to object detection which detect objects by building adaptive models of the only background, the foreground is also modeled to augment the detection of objects (without explicit tracking) since objects detected in a preceding frame contain substantial evidence for detection in a current frame. Third, the background and foreground models are used competitively in a MAP-MRF decision framework, stressing spatial context as a condition of pixel-wise labeling and the posterior function is maximized efficiently using graph cuts. Experimental validation of the proposed method is presented on a diverse set of dynamic scenes.
Secondary neuroprotective effects of hypotensive drugs and potential mechanisms of action (2012)

Primary open-angle glaucoma, a long-term degenerative ocular neuropathy, remains a significant cause of vision impairment worldwide. While many risk factors have been correlated with increased risk for primary open-angle glaucoma, intraocular pressure (IOP) remains the only modifiable risk factor and primary therapeutic target. Pharmacologic therapies are administered topically; these include α(2)-agonists, β-antagonists, prostaglandin analogs and carbonic anhydrase inhibitors. Some of these topical medications exhibit secondary neuroprotective effects independent of their effect on IOP. This review covers the possible mechanisms of neuroprotection stimulated by drugs currently marketed for the lowering of IOP, based on known literature. While the neuroprotective properties of many glaucoma pharmaceuticals are promising from an experimental standpoint, key challenges for the development of new clinical practices include unknown systemic side effects, limited methods of drug delivery to the retina and optic nerve, and development of extended-release formulations.
Network Assisted Mobility Support for 6LoWPAN (2009)

This paper presents a network-assisted mobility support scheme for 6LoWPAN nodes, which enables multi-hop communication between the Gateway (GW) and the Mobile 6LoWPAN devices (MNs), with minimum mobility related signaling at the MN's end as compared to conventional mobility related protocols like MIPv6. The scheme provides mobility support to the MNs with the help of low cost static 6LoWPAN devices (SNs) which can be deployed in large numbers. In order to reduce the handover latency, the MN in the proposed scheme is assigned a fixed address which remains unchanged during its course of movement within the network. Moreover the scheme aims to reduce packets loss of the MN by predicting its future location and having a provision of buffering its packet at SNs when needed. The signaling overhead consumption needed to support a MN is determined through analytical modeling.
Regulatory factors produced by lymphocytes. II. Inhibition of cellular DNA synthesis associated with a factor inhibiting DNA polymerase alpha activity. (1977)

Supernatants of phytohemagglutinin-stimulated human tonsil cells contain two growth inhibitory factors. These factors, called inhibitors of DNA synthesis (IDS), reduce (3)H-thymidine incorporation into mitogen-stimulated lymphocytes and into growing HeLa cells. By Sephadex chromatography, these factors have volumes of distribution corresponding to about 80,000 and 40,000 daltons. Both factors inhibit the activity of calf thymus DNA polymerase alpha in cell-free assays (termed inhibitor of DNA polymerase, IDP). The larger factor, which is chromatographically separable from alpha-lymphotoxin (alpha-LT), is completely inactivated by heating at 70 degrees C for 15 min. This treatment does not destroy alpha-LT. Using supernatants from PHA-stimulated tonsil cells cultured for 5 days in serum-free medium, we attained a 150-fold purification with a succession of molecular sieving, ion exchange, and adsorption chromatographic procedures. Although not purified to homogeneity, the extensive copurification of IDS and IDP activities and their identical heat inactivation profiles suggest that they are the same entity. IDP separated free of alpha-LT inhibits thymidine incorporation into HeLa cells without causing cell death. alpha-LT purified free of IDS does not inhibit thymidine incorporation into HeLa cells, not even at concentrations 7000 times that necessary to kill 50% of growth-inhibited L cell cultures.