gebhart/patrepeval huggingface dataset:
Lomotil poisoning in children. (1979)

45 children were admitted to hospital after ingesting varying quantities of diphenoxylate (Lomotil). One died and 44 recovered without any sequelae. Four patients were comatose, 32 were drowsy, and 9 suffered respiratory depression. No correlation was found between ingested dose and the severity of symptoms. Because of its action in rendering the gut atonic, removal of diphenoxylate by gastric lavage is mandatory, even in patients admitted at least 24 hours after drug ingestion. Naloxone is the narcotic antagonist of choice, and should be used in all cases where suspected diphenoxylate poisoning leads to respiratory depression or coma. The use of Lomotil as an antidiarrhoeal agent in children is difficult to justify.
Assay of Uranium in the Presence of Various Interfering Ions Using Ion Pair Liquid Chromatography (1993)

Abstract A sensitive and specific method for uranium(VI) determination using reverse phase ion-pair high performance liquid chromatography with UV detector has been developed. The developed method has been applied for the determination of uranium in a synthetic sample containing most of the interfering ions. Except iron most of the elements and anion which often interfere in uranium assay do not interfere in the present method. Interference of iron is masked by addition of 5mM/l EDTA solution to the sample.
Eimco/Wemco has solutions to waste handling problems (1993)

The Eimco/Wemco organisation succeeds on a combination of advanced application engineering capability, worldwide manufacturing facilities, and comprehensive technical and laboratory support. Its core expertise is solid/liquid separation, and it has a wide range of products for application in classification, sedimentation, filtration, polishing, attrition, flotation, aeration etc. Here we look at its activities In filtration and separation, and at some recent projects.
Common variant of ALPK1 is not associated with gout: a replication study (2014)

Gout is one of the most kinds of common inflammatory arthritis as a consequence of hyperuricemia. Alpha-protein kinase 1 (ALPK1) gene locates in a gout-susceptibility locus on chromosome 4q21-31, and encodes ALPK1 protein which plays a pivotal role in the phosphorylation of myosin 1. In the previous genetic study of Taiwanese populations, 3 single nucleotide polymorphisms (SNPs), rs11726117, rs231247 and rs231253, in ALPK1 gene were reported to have a significant association with gout. However, no replication study has been performed to confirm this association. Therefore, we first conducted a replication study with clinically defined gout patients in a different population. Linkage disequilibrium (LD) analyzes of the 3 SNPs in ALPK1 revealed that these SNPs are in strong LD in a Japanese population. Among the 3 SNPs of ALPK1, rs11726117 (M861T) is the only missense SNP. Therefore, rs11726117 was genotyped in a Japanese population of 903 clinically defined gout cases and 1,302 controls, and was evaluated for a possible association with gout. The minor allele frequencies of rs11726117 were 0.26 and 0.25 in the case and control groups, respectively. The association analysis has not detected a significant association between rs11726117 and gout susceptibility in a Japanese population (p = 0.44). Because ABCG2, a major causative gene for gout, also locates in the gout-susceptibility locus on chromosome 4q, these findings suggest that among genes in a gout-susceptibility locus, not ALPK1 but ABCG2 could be important as a gout-susceptible gene.
Structure of the oligosaccharide of human J chain. (1979)

The complete structure of the oligosaccharide moiety of J chain isolated from a Waldenströms macroglobulin Wa has been established. The oligosaccharide is present in three forms differing in the amount of sialic acid and designated J-A, J-B, and J-C. The structure and proportion of each of these is: formula : (see text) : Removal of the oligosaccharide moiety with glycosidases results in an increased mobility of J chain in sodium dodecyl sulfate polyacrylamide gel electrophoresis corresponding to a shift in apparent molecular weight from 23,500 to 19,500. The preparation and utilization of iodinated glycopeptides for sequence analysis is presented.
Is hemochromatosis a risk factor for Alzheimer's disease? (2001)

Excess iron accumulation in the brain is a consistent observation in Alzheimer's Disease. Iron affects amyloid precursor protein (AbetaPP) processing and promotes deposition of Abeta. Iron is also among the most potent biological toxins because of its ability to react with oxygen to form reactive oxygen species. Consequently, elucidation of the mechanisms associated with maintaining brain iron homeostasis is fundamentally important to understanding the underlying pathogenesis in AD. The iron overload disorder, Hemochromatosis, is the most common genetic disorder (1:200) so a significant percentage of AD patients can be expected to carry this mutation. Heterozygotes for this mutation also have an increased, but sub-clinical iron burden. Given the high percentage of the population who are at significant risk for iron overload, we propose that the hemochromatosis mutation be considered as a confounding factor when evaluating the contribution of genetic associations with AD and treatment strategies and efficacy. Two recent papers and new evidence presented here that the protein associated with hemochromatosis is expressed on blood vessels, choroid plexus and the ependymal cells in the brain are offered as support for this proposal.
Morphological Change by Overexpression of D385A Dominant Negative Presenilin 1 in Human Neuroblastoma SH-SY5Y Cells (2006)

Presenilin 1 (PS1) is a multifunctional protein, and its mutations are highly related to familial Alzheimer's disease (AD). In this study, we examined the effects of PS1 overexpression on neuronal morphology using SH-SY5Y cells. Overexpression of dominant-negative D385A PS1 induced morphological change and impairment of neurite formation, while those of wild-type and pathogenic P117L mutant PS1 did not change cellular morphology compared with native cells. Moreover, filopodium-formation-related proteins were decreased only in cells overexpressing D385A PS1. Therefore, PS1 may be involved in neuritogenesis and morphological change in SH-SY5Y cells, and P117L mutation may linked to AD by different mechanisms.
A biologically inspired multimodal whisker follicle (2016)

Mammalian whisker follicle contains multiple sensory receptors strategically organized to capture tactile sensory stimuli of different frequencies via the vibrissal system. There have been a number of attempts to develop robotic whiskers to perform texture classification tasks in the recent past. Inspired by the features of biological whisker follicle, in this paper we design and use a novel soft whisker follicle comprising of two different frequency-dependent data capturing modules to derive deeper insights into the biological basis of tactile perception in the mammalian whisker follicle. In our design, the innervations at the Outer Conical Body (OCB) of a biological follicle are realized by a piezoelectric transducer for capturing high frequency components; whereas the innervations around the hair Papilla are represented by a hall sensor to capture low frequency components during the interaction with the environment. In this paper, we show how low dimensional information such as the principle components of co-variation of these two sensory modalities vary for different speeds and indentations of brushing the whisker against a surface. These new insights into the biological basis of tactile perception using whiskers provides new design guidelines to develop efficient robotic whiskers.
Space Plan Generator: Rapid Generationn & Evaluation of Floor Plan Design Options to Inform Decision Making (2016)

Design exploration in architectural space planning is often constrained by tight deadlines and a need to apply necessary expertise at the right time. We hypothesize that a system that can computationally generate vast numbers of design options, respect project constraints, and analyze for client goals, can assist the design team and client to make better decisions. This paper explains a research venture built from insights into space planning from senior planners, architects, and experts in the field, coupled with algorithms for evolutionary systems and computational geometry, to develop an automated computational framework that enables rapid generation and analysis of space plan layouts. The system described below automatically generates hundreds of design options from inputs typically provided by an architect, including a site outline and program document with desired spaces, areas, quantities, and adjacencies to be satisfied. We envision that this workflow can clarify project goals early in the design process, save time, enable better resource allocation, and assist key stakeholders to make informed decisions and deliver better designs. Further, the system is tested on a case study healthcare design project with set goals and objectives.
A direct search method for the computer design of holograms (1993)

A new optimisation technique for the computer design of holograms has been developed. It has much in common with simulated annealing but requires less computational effort. Additionally the technique is not restricted to any particular holographic set up such as Fourier transform holograms. The method has been used to design phase holograms for laser machining at CO/sub 2/ wavelengths. To evaluate the technique these elements have been re-scaled for reconstruction at HeNe wavelengths. They have been reconstructed optically as well as digitally and the results from these exercises used.
Conversion of methionine into homocysteic acid in heavily oxidized proteomics samples (2010)

Analysis of protein oxidation is necessary in numerous areas of biochemistry, including hydroxyl radical surface mapping, oxidative stress assays, and pharmaceutical stability testing. Mass spectrometry is one of the tools most often used to identify protein oxidation products, and previous studies have attempted to identify and characterize all of the major oxidation products detected by mass spectrometry for each amino acid residue. In this note, we present evidence that in heavily oxidized protein samples, such as those produced by hydroxyl radical surface mapping, a major oxidation product of methionine is homocysteic acid. The formation of homocysteic acid from methionine was previously unrecognized in other mass spectrometric analyses, and has important implications for the analysis of oxidized samples, as well as potential implications as to the functional consequences of methionine oxidation.
Sealed storage for trusted cloud computing (2010)

In cloud computing, cloud user's sensitive data is in the control of a third part, which will lead to considerable risk on the privacy and security of the data. To address this problem we propose a trusted cloud computing platform with sealed storage ability (TSSC). TSSC enable Infrastructure as a Service provider (IaaS) such as Amazon EC2 to provide remote attestation to the IaaS user by an attestation delegation server and seal the IaaS user's sensitive data with their desired integrity of the IaaS configuration. We implement our solution on Xen, and present a simple prototype based Nimbus. Our evaluation results show that the performance overhead of the solution is acceptable.
Risk-Averse Group Elevator Scheduling (2004)

We introduce a novel group elevator scheduler based on an explicit decision-theoretic calculation for the expectation of any polynomial function of passengers’ waiting times, marginalized over sources of uncertainty in the system state. The same framework can be used to identify risky assignments that have low expected costs but may cause some individuals to be ”stranded ” with excessive waits for service. The resulting scheduler avoids risky assignments while minimizing average passenger waits. Experimental results demonstrate that the method can reduce the variance of waiting times and the fraction of passengers waiting excessively in comparison with risk-neutral schedulers, while still achieving better waiting times than reference ETA controllers.
Axial x-ray preionized XeCl laser and direct comparison with UV preionization mode (1985)

Axial x-ray preionization of a compact XeCl laser is demonstrated; significant improvements (∼1.5) in laser performance compared with an optimized UV preionization array are obtained. This simple and compact technique can readily be incorporated into existing lasers.
Distribution of angle-of-arrival and delay from array of buildings placed on rough terrain for various elevations of base station antenna (2000)

A unified three-dimension probabilistic model is presented to describe multipath phenomena in various built-up areas with randomly distributed buildings placed on rough terrain. The joint information regarding angle-of-arrival and time delay spread is obtained through study of the main propagation mechanisms in urban wireless communication channels. Comparison with other models and with measurements carried out in different urban environments is presented. It is shown that in dense urban areas the distribution of the obstructions surrounding the base station and the moving vehicle, as well as the elevations of both antennas contribute to the signal power profiles in the space and time domains. Using a combination of the statistical description of the built-up terrain and the 3D deterministic approach based on Kirchhoff approximation, the effects of scattering and diffraction phenomena on signal power spatial and temporal distribution are examined.
Fast image/video upsampling (2008)

We propose a simple but effective upsampling method for automatically enhancing the image/video resolution, while preserving the essential structural information. The main advantage of our method lies in a feedback-control framework which faithfully recovers the high-resolution image information from the input data, without imposing additional local structure constraints learned from other examples. This makes our method independent of the quality and number of the selected examples, which are issues typical of learning-based algorithms, while producing high-quality results without observable unsightly artifacts. Another advantage is that our method naturally extends to video upsampling, where the temporal coherence is maintained automatically. Finally, our method runs very fast. We demonstrate the effectiveness of our algorithm by experimenting with different image/video data.
Status and future prospects on the development of thermoelectric power generation systems utilizing combustion heat from municipal solid waste (2002)

The characteristics of combustion heat from the municipal solid waste are fitted for a large-scale application of thermoelectric power generation potentially. The status and future prospects of thermoelectric power generation systems to recover electricity from this heat source in Japan are reviewed and discussed. Experimental results on three different types of small-scale (500 W class) thermoelectric power generation systems installed in the real municipal solid waste processing systems to demonstrate the technological feasibility and to extract the technological problems are briefly introduced. The conceptual designs of a small scale system for the next phase of the R&D program are presented. From the view point of large-scale realization the thermoelectric material and modules configurations required for this application are also discussed. A case study on the marginal cost estimation shows the cost reduction to be less than 0.4-0.5 Million Yen/kW in order to make a profit on this system.
Electrocatalysis in wastewater treatment: recent mechanism advances (2011)

Over 50 years, several scientists and industries have developed new alternatives for wastewater treatment and remediation. Recently, electrochemical technology has been largely developed mainly because of its versatility and environmental compatibility. Scientific contributions about role of the electrode material have allowed determining that the influence of material in the selectivity is an important parameter. However, to interpret this behavior, comprehensive physical chemistry models for organics destruction, related to electrochemical phenomena and material surfaces, were proposed in the last decades. So, this paper presents a critical and comprehensive review about the principles and recent mechanism advances in electrocatalysis for wastewater treatment.
PtABI3 Impinges on the Growth and Differentiation of Embryonic Leaves during Bud Set in Poplar (2002)

The Arabidopsis ABSCISIC ACID-INSENSITIVE3 (ABI3) protein plays a crucial role during late seed development and has an additional function at the vegetative meristem, particularly during periods of growth-arresting conditions and quiescence. Here, we show that the ABI3 homolog of poplar (PtABI3) is expressed in buds during natural bud set. Expression occurs clearly after perception of the critical daylength that initiates bud set and dormancy in poplar. In short-day conditions mimicking natural bud set, the expression of a chimeric PtABI3::beta-glucuronidase (GUS) gene occurred in those organs and cells of the apex that grow actively but will undergo arrest: the young embryonic leaves, the subapical meristem, and the procambial strands. If PtABI3 is overexpressed or downregulated, bud development in short-day conditions is altered. Constitutive overexpression of PtABI3 resulted in apical buds with large embryonic leaves and small stipules, whereas in antisense lines, bud scales were large and leaves were small. Thus, PtABI3 influences the size and ratio of embryonic leaves and bud scales/stipules that differentiate from the primordia under short-day conditions. These observations, together with the expression of PtABI3::GUS in embryonic leaves but not in bud scales/stipules, support the idea that wild-type PtABI3 is required for the relative growth rate and differentiation of embryonic leaves inside the bud. These experiments reveal that ABI3 plays a role in the cellular differentiation of vegetative tissues, in addition to its function in seeds.
The influence and utility of varying field strength for the separation of tryptic peptides by ion mobility-mass spectrometry (2004)

The influence of field strength on the separation of tryptic peptides by drift tube-based ion mobility-mass spectrometry is reported. Operating the ion mobility drift tube at elevated field strengths (expressed in V cm(-1) torr(-1)) reduces separation times and increases ion transmission efficiencies. Several accounts in the literature suggest that performing ion mobility separation at elevated field strength can change the selectivity of ion separation. To evaluate the field strength dependant selectivity of ion mobility separation, we examined a data set of 65 singly charged tryptic peptide ion signals (mass range 500-2500 m/z) at six different field strengths and four different drift gas compositions (He, N2, Ar, and CH4). Our results clearly illustrate that changing the field strength from low field (15 V cm(-1) torr(-1)) to high field (66 V cm(-1) torr(-1)) does not significantly alter the selectivity or peak capacity of IM-MS. The implications of these results are discussed in the context of separation methodologies that rely on the field strength dependence of ion mobility for separation selectivity, e.g., high-field asymmetric ion mobility spectrometry (FAIMS).
Grids, Accounting and High-Performance Computing (2007)

The rapidly increasing capabilities of networks enable the construction of wide-area integrated environments for collaboration and sharing of instruments, data, and computational and storage resources. We will briefly present some current Grid infrastructure developments, some of the associated challenges, and some of our own research in regards to standards based non-intrusive Grid accounting, and techniques for design and implementation of scientific software libraries achieving portability across platforms with preservation of efficiency to the extent possible.
Thyroid Peroxidase: Rat cDNA Sequence, Chromosomal Localization in Mouse, and Regulation of Gene Expression by Comparison to Thyroglobulin in Rat FRTL-5 Cells (1989)

A rat thyroid peroxidase cDNA has been isolated from a FRTL-5 thyroid cell library and sequenced. The cDNA is 2776 base pairs long with an open reading frame of 770 amino acids. By comparison to full-length human thyroid peroxidase cDNA and based on its identification of a 3.2 kilobase mRNA in rat thyroid FRTL-5 cell Northern blots, the rat peroxidase cDNA appears to lack 400-500 base pairs at the 5'-end of the mRNA. It exhibits only a 74% nucleotide and 77% amino acid sequence similarity to human thyroid peroxidase cDNA within the total aligned sequences, although the predicted active site regions are highly conserved (greater than 90-100%). The cDNA has been used to map the thyroid peroxidase gene in mice to chromosome 12 and to compare thyroid peroxidase and thyroglobulin gene expression in FRTL-5 rat thyroid cells. Despite the fact TSH action in both cases is duplicated, and presumably mediated, by cAMP, TSH-induced increases in thyroid peroxidase and thyroglobulin mRNA levels differ. Differences exist with respect to hormone concentration and time. The ability of TSH to increase thyroglobulin, but not thyroid peroxidase mRNA levels, requires insulin, 5% serum, or insulin-like growth factor-I. Insulin or insulin-like growth factor-I alone can increase thyroglobulin mRNA levels as well as or better than TSH but have only a small effect on thyroid peroxidase mRNA levels by comparison to TSH. The ability of TSH to increase thyroglobulin gene expression is readily detected in nuclear run-on assays but not the ability of TSH to increase thyroid peroxidase gene expression. Cycloheximide inhibits TSH-increased thyroglobulin but not peroxidase mRNA levels. Finally, methimazole and phorbol 12-myristate 13-acetate show different effects on TSH-induced increases in thyroglobulin and thyroid peroxidase mRNA levels.
Real time control of arc fusion for optical fiber splicing (1993)

A real-time control procedure has been developed for controlling arc fusion splicing of optical fibers. This procedure is applied during the fusion in order to optimize the fusion parameters for different types of optical fibers under different electrode conditions. The procedure has been implemented in a fusion splicer. Consistent splice losses have been achieved for different fibers under different fusion environment.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Hemoxygenase-2 Is an Oxygen Sensor for a Calcium-Sensitive Potassium Channel (2004)

Modulation of calcium-sensitive potassium (BK) channels by oxygen is important in several mammalian tissues, and in the carotid body it is crucial to respiratory control. However, the identity of the oxygen sensor remains unknown. We demonstrate that hemoxygenase-2 (HO-2) is part of the BK channel complex and enhances channel activity in normoxia. Knockdown of HO-2 expression reduced channel activity, and carbon monoxide, a product of HO-2 activity, rescued this loss of function. Inhibition of BK channels by hypoxia was dependent on HO-2 expression and was augmented by HO-2 stimulation. Furthermore, carotid body cells demonstrated HO-2-dependent hypoxic BK channel inhibition, which indicates that HO-2 is an oxygen sensor that controls channel activity during oxygen deprivation.
Dispersion Polymerization of Vinyl Monomers in Supercritical Carbon Dioxide (2002)

超臨界CO2を溶媒とした重合反応を行い, poly (1, 1, 2, 2-tetrahydroheptadeca-fluorodecyl acrylate) およびpoly (1, 1, 2, 2-tetrahy-droheptadeca-fluorodecyl methacrylate) を得た。得られた高分子を界面活性剤として用い, 超臨界二酸化炭素を溶媒とした種々のビニルモノマーの分散重合を行った。ガラス転移点が高い高分子についてはPowder (球形微粒子) が得られたが, ガラス転移点が低い高分子に関しては分散が困難で, またモノマーの重合転化率も低かった。これは, 今回合成した高分子の分子量が低く, 分散相の安定化が低かったためと考えられる。ESCAを用いて得られたPowderの表面分析を行ったところ, 粉体表面にフッ素が濃縮されていることを確認した。重合条件によっては, スポンジ状の三次元ネットワーク構造をもつPowderが得られる場合があったが, その原因は不明である。