gebhart/patrepeval huggingface dataset:
Behavioral, Pharmacological, and Molecular Characterization of an Amphibian Cannabinoid Receptor (2000)

Investigation of cannabinoid pharmacology in a vertebrate with a phylogenetic history distinct from that of mammals may allow better understanding of the physiological significance of cannabinoid neurochemistry. Taricha granulosa, the roughskin newt, was used here to characterize an amphibian cannabinoid receptor. Behavioral experiments demonstrated that the cannabinoid agonist levonantradol inhibits both newt spontaneous locomotor activity and courtship clasping behavior. Inhibition of clasping was dose-dependent and potent (IC(50) = 1.2 microgram per animal). Radioligand binding studies using [(3)H]CP-55940 allowed identification of a specific binding site (K(D) = 6.5 nM, B(max) = 1,853 fmol/mg of protein) in brain membranes. Rank order of affinity of several ligands was consistent with that reported for mammalian species (K(D), nM) : CP-55940 (3.8) > levonantradol (13.0) > WIN55212-2 (25.7) >> anandamide (1,665) approximately anandamide 100 microM phenylmethylsulfonyl fluoride (2,398). The cDNA encoding the newt CB1 cannabinoid receptor was cloned, and the corresponding mRNA of 5.9 kb was found to be highly expressed in brain. A nonclonal Chinese hamster ovary cell line stably expressing the newt CB1 cannabinoid receptor was prepared that allowed demonstration of cannabinoid-mediated inhibition of adenylate cyclase (EC 4.6.1.1) activity. This inhibition was dose-dependent and occurred at concentrations consistent with affinities determined through radioligand binding experiments. The behavioral, pharmacological, and molecular cloning results demonstrate that a CB1 cannabinoid receptor is expressed in the CNS of the roughskin newt. This amphibian CB1 is very similar in density, ligand binding affinity, ligand binding specificity, and amino acid sequence to mammalian CB1. The high degree of evolutionary conservation of cannabinoid signaling systems implies an important physiological role in vertebrate brain function.
Adaptive beam-steering antenna for improved coverage of non-contact vital sign radar detection (2014)

This paper presents an adaptive beam-steering antenna for non-contact vital sign radar system at 5.8 GHz. A 2X2 microstrip patch antenna and two phase shifters are manufactured on the same board. Phase shifters consisting of 4 single pole double throw (SPDT) switches are integrated into the matching network of the phase array antenna to save the area. Beam-steering function is controlled by the active phase shifter. The DC bias circuit of the phase shifter is connected with the back side of the antenna through headers. Both simulation and measurement show an antenna bandwidth of 200 MHz centered at 5.8 GHz, which is suitable for a 5.8 GHz non-contact vital sign radar system. The radiation beam of this antenna can steer from −22° to 22° in H-plane, which increases the antenna coverage to 85° without sacrificing antenna gain. Measurement shows the adaptive beam-steering antenna can successfully detect human vital signs while the fixed-beam 2×2 antenna fails due to the limited and fixed antenna beam coverage. The improved performance without increasing antenna area makes the adaptive beam-steering antenna more suitable for commercial application.
The Nursing Home and Assorted Ironies (1981)

The Nursing Home and Assorted Ironies Get access Health & Social Work, Volume 6, Issue 2, May 1981, Pages 2–3, https://doi.org/10.1093/hsw/6.2.2 Published: 01 May 1981
Instantaneous image observation of ultrafast electrical pulse propagating on metal strip (2002)

Instantaneous potential distribution of 2 ps propagating pulse was visualized using a scanning force optoelectronic microscope. A special probe made of low temperature grown GaAs is the key in the optical sampling measurement.
Colloids decrease clot propagation and strength: role of factor XIII‐fibrin polymer and thrombin–fibrinogen interactions (2005)

Colloid-mediated hypocoagulability is clinically important, but the mechanisms responsible for coagulopathy have been incompletely defined. Thus, my goal was to elucidate how colloids decrease plasma coagulation function. Plasma was diluted 0% or 40% with 0.9% NaCl, three different hydroxyethyl starches (HES, mean molecular weight 450, 220 or 130 kDa), or 5% human albumin. Samples (n=6 per condition) were activated with celite, and diluted samples had either no additions or addition of fibrinogen (FI), thrombin (FIIa) or activated Factor XIII (FXIIIa) to restore protein function to prediluted values. Thrombelastographic variables measured included clot propagation (angle, alpha), and clot strength (amplitude, A; or shear elastic modulus, G). Dilution with 0.9% NaCl significantly decreased alpha, A and G-values compared to undiluted samples. Supplementation with FI, but not FIIa or FXIIIa, resulted in 0.9% NaCl-diluted thrombelastographic variable values not different from those of undiluted samples. FI supplementation of HES 450, HES 220, HES 130 and albumin-diluted samples only partially restored alpha, A and G-values compared to undiluted samples. FIIa addition only improved clot propagation and strength in albumin-diluted samples. FXIIIa supplementation improved propagation in samples diluted with HES 450, HES 220 and albumin, and clot strength improved in HES 450 and albumin-diluted plasma. Considered as a whole, these data support compromise of FIIa-FI and FXIIIa--fibrin polymer interactions as the mechanisms by which colloids compromise plasma coagulation. Investigation to determine if clinical enhancement of FXIII activity and/or FI concentration (e.g. fresh-frozen plasma, cryoprecipitate) can attenuate colloid-mediated decreases in hemostasis is warranted.
The Beckmann rearrangement of some pyrazolyl oximes (1969)

The oximes of several pyrazolyl carbonyl compounds have been prepared, in some cases both as syn- and anti-isomers. They have been subjected to the Beckmann rearrangement with phosphorus pentachloride, toluene-p-sulphonyl chloride, concentrated sulphuric acid, and polyphosphoric acid. With di-(1-phenylpyrazol-4-yl) ketoxime, 4-benzoyl-1-phenylpyrazole oximes, 4-acetyl-1-phenylpyrazole oximes, ethyl 1-phenylpyrazol-4-yl ketoxime and isopropyl 1-phenylpyrazol-4-yl ketoxime, the rearrangements were found to proceed in a normal, intramolecular fashion to yield N-substituted amides, although sulphuric acid was found to be a poor reagent. The operation of a two-stage, fragmentation–recombination mechanism for the Beckmann rearrangement of t-butyl 1-phenylpyrazol-4-yl ketoxime in polyphosphoric acid has been demonstrated by crossed experiments, in which the nitrile or the electrofuge formed by fragmentation of the oxime was trapped before recombination could occur. The recombination step between the nitrile and electrofuge has been independently demonstrated under Beckmann rearrangement conditions. Pyrazolyl aldoximes failed to undergo the Beckmann rearrangement. N.m.r. spectroscopy has been used to assign configurations to all the pyrazolyl oximes except those of 4-acetyl-1-phenylpyrazole.
<title>Optimization of photodynamic therapy: the influence of photosensitizer uptake and distribution on tumor response</title> (2001)

PDT is being used to treat small localized cancer or as an adjuvant to debulking surgery for more advanced disease. Clinical protocols for PDT are based on the assumption that optimum intervals between photosensitizer administration and illumination are at times of maximum differential between drug retention in tumor and surrounding normal tissue. Tumor destructing can, however, occur either by direct cell killing or by vascular mediated damage. The aim of this study was to investigate the relationship between plasma and tumor photosensitizer levels and PDT effect for the RIF1 murine tumor and the H-MESO1 xenograft tumor. mTHPC plasma levels decreased rapidly according to a biexponential fit. The tumor drug levels, however increased from 5 minutes to 6 hours after injection and remained high for at least 48 hours. Maximum tumor PDT response was seen at 1 to 3 hour drug-light intervals with very little effect for drug-light intervals > 24 hours. No correlation was found between tumor mthpc levels and tumor response, whereas plasma mTHPC levels and PDT correlated significantly. These studies support the hypothesis that vascular mediated damage is more important than direct tumor cell toxicity and that it is drug exposure of endothelial cells in vessels feeding the tumor which determines PDT response.
Metabolizing enzyme toxicology assay chip (MetaChip) for high-throughput microscale toxicity analyses (2005)

The clinical progression of new chemical entities to pharmaceuticals remains hindered by the relatively slow pace of technology development in toxicology and clinical safety evaluation, particularly in vitro approaches, that can be used in the preclinical and early clinical phases of drug development. To alleviate this bottle-neck, we have developed a metabolizing enzyme toxicology assay chip (MetaChip) that combines high-throughput P450 catalysis with cell-based screening on a microscale platform. The MetaChip concept is demonstrated by using sol-gel encapsulated P450s to activate the prodrug cyclophosphamide, which is the major constituent of the anticancer drug Cytoxan, as well as other compounds that are activated by P450 metabolism. The MetaChip provides a high-throughput microscale alternative to currently used in vitro methods for human metabolism and toxicology screening based on liver slices, cultured human hepatocytes, purified microsomal preparations, or isolated and purified P450s. This technology creates opportunities for rapid and inexpensive assessment of ADME/Tox (absorption, distribution, metabolism, excretion/toxicology) at very early phases of drug development, thereby enabling unsuitable candidates to be eliminated from consideration much earlier in the drug discovery process.
Learning Based Robotic Bin-picking for Potentially Tangled Objects (2019)

In this research, we tackle the challenge of picking only one object from a randomly stacked pile where the objects can potentially be tangled. No solution has been proposed to solve this challenge due to the complexity of picking one and only one object from the bin of tangled objects. Therefore, we propose a method for avoiding the situation where a robot picks multiple objects. In our proposed method, first, grasping pose candidates are computed by using the graspability index. Then, a Convolutional Neural Network (CNN) is trained to predict whether or not the robot can pick one and only one object from the bin. Additionally, since a physics simulator is used to collect data to train the CNN, an automatic picking system can be built. The effectiveness of the proposed method is confirmed through experiments on robot Nextage and compare with previous bin-picking methods.
A new super-resolution 3D-SAR imaging method based on MUSIC algorithm (2011)

This paper presents a new imaging method for linear array SAR (LASAR) based on multiple signal classification (MUSIC) algorithm. Limited by the length of linear array antenna in practice, LASAR has a much lower resolution in cross-track (CT) direction than the resolution in range and along-track (AT) direction. Besides, to traditional matched filter (MF) method, restricted by the Rayleigh limit, the resolution of along-track direction is difficult to rise. To overcome these limitations, this paper applies 2D-MUSIC algorithm in cross track direction and along-track direction instead of traditional matched filter method. According to the new imaging method based on 2D-MUSIC algorithm, imaging result of high resolution can be recovered from the noisy scene. Under the same system parameters, compared with traditional method, the presented new imaging method can greatly improve imaging resolution and suppress the side-lobe for LASAR 3D imaging in cross-track direction and along-track direction. The simulated results confirm the validity of the method and show that it can improve the imaging quality.
Minimizing private data disclosures in the smart grid (2012)

Smart electric meters pose a substantial threat to the privacy of individuals in their own homes. Combined with non-intrusive load monitors, smart meter data can reveal precise home appliance usage information. An emerging solution to behavior leakage in smart meter measurement data is the use of battery-based load hiding. In this approach, a battery is used to store and supply power to home devices at strategic times to hide appliance loads from smart meters. A few such battery control algorithms have already been studied in the literature, but none have been evaluated from an adversarial point of view. In this paper, we first consider two well known battery privacy algorithms, Best Effort (BE) and Non-Intrusive Load Leveling (NILL), and demonstrate attacks that recover precise load change information, which can be used to recover appliance behavior information, under both algorithms. We then introduce a stepping approach to battery privacy algorithms that fundamentally differs from previous approaches by maximizing the error between the load demanded by a home and the external load seen by a smart meter. By design, precise load change recovery attacks are impossible. We also propose mutual-information based measurements to evaluate the privacy of different algorithms. We implement and evaluate four novel algorithms using the stepping approach, and show that under the mutual-information metrics they outperform BE and NILL.
Cystic lymphangioma of sigmoid flexure (1962)

Summary Attention has been directed to the rarity of cystic lymphangioma of the colon and rectum, having been reported only 15 times in medical literature. The case described in this report was discovered incidentally while treating a patient for cancer of the rectum. © The ASCRS 1962
Feature Selection for Genomic and Proteomic Data Mining (2008)

This chapter contains sections titled: Introduction Quantifying Information/Redundancy of/among Features Consecutive Ranking of Features Supervised Feature Selection and Extraction Feature Selection VIA Vector-Index-Adaptive SVM for Fast Subcellular Localization Conclusion Acknowledgments References
Explanation capabilities of production-based consultation systems (1977)

A computer program that models an expert in a given domain is more likely to be accepted by experts in that domain, and by non-experts seeking its advice, if the system can explain its actions. An explanation capability not only adds to the system''s credibility, but also enables the non-expert user to learn from it. Furthermore, clear explanations allow an expert to check the system''s reasoning, possibly discovering the need for refinements and additions to the system''s knowledge base. In a developing system, an explanation capability can be used as a debugging aid to verify that additions to the system are working as they should. This paper discusses the general characteristics of explanation systems: what types of explanations they should be able to give, what types of knowledge will be needed in order to give these explanations, and how this knowledge might be organized. The explanation facility in MYCIN is discussed as an illustration of how the various problems might be approached.
Effect of 6-Azacytidine on the Course of Experimental Adenoviral Infection in Newborn Syrian Hamsters (2007)

Adenoviral infection is a serious human pathology leading to respiratory, gastrointestinal and ocular disorders and epidemic outbreaks, especially in children's groups. Here we present the results from an investigation of anti- adenoviral effect of 6-azacytidine (6-AC) both in vitro and in vivo. The selectivity index of 6-AC for adenovirus type 5 in HEp-2 cells was 374, the 50% effective concentration was 0.5 mg/ml. For in vivo investigations we developed a model of disseminated adenoviral infection in newborn Syrian hamsters. The infectious virus was recovered from the liver, kidney, lungs and heart. Application of 6-AC led to a reduced period of the virus presence (7 days in the liver and 4 days in the kidney and heart) and lowered virus titers on day 3 post-inoculation (p.i.) (liver - 2.7 and 4.1, heart - 0 and 3.2, kidney - 0 and 2.4 log(10 )CPD(50)/mg tissue weight, in the presence and absence of 6-AC, respectively). Application of 6-AC to newborn Syrian hamsters led to partial destruction of their splenocytes. The results obtained suggest that 6-AC or 6-ACbased drugs with lower toxicity or applied topically may be suitable for therapy and prevention of adenoviral infection in humans.
Genome-wide analysis of the grapevine stilbene synthase multigenic family: genomic organization and expression profiles upon biotic and abiotic stresses (2012)

This study represents an overview of the expression pattern of each member of the STS gene family in grapevine under both constitutive and stress-induced conditions. The results strongly indicate the existence of a transcriptional subfunctionalization amongst VvSTSs and provide the foundation for further functional investigations about the role and evolution of this large gene family. Moreover, it represents the first study to clearly show the differential regulation of VvCHS and VvSTS genes, suggesting the involvement of transcription factors (TFs) in both the activation and repression of these genes.
Poly(thionylphosphazenes): a new class of inorganic polymers with skeletal phosphorus, nitrogen, and sulfur(VI) atoms (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPoly(thionylphosphazenes): a new class of inorganic polymers with skeletal phosphorus, nitrogen, and sulfur(VI) atomsMong Liang and Ian MannersCite this: J. Am. Chem. Soc. 1991, 113, 10, 4044–4045Publication Date (Print):May 1, 1991Publication History Published online1 May 2002Published inissue 1 May 1991https://doi.org/10.1021/ja00010a085RIGHTS & PERMISSIONSArticle Views328Altmetric-Citations99LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (277 KB) Get e-Alerts Get e-Alerts
Pervivencia histórica y proyección sintáctica de la concinnitas (1987)

No disponible.
SOURCE WANTED (1977)

Journal Article SOURCE WANTED Get access MORTON N. COHEN MORTON N. COHEN Program in English, Graduate School of the City University, 33 West 42nd Street, New York, New York 10036, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume CCXXII, Issue jan, January 1977, Pages 49-a–49, https://doi.org/10.1093/notesj/CCXXII.jan.49a Published: 01 January 1977
Pattern-evoked potentials and optic nerve fiber loss in monocular laser-induced glaucoma. (1989)

ERG and VEP responses to counterphase checkerboard stimuli were obtained from cynomolgus monkeys with monocular glaucoma induced by laser photocoagulation of the trabecular meshwork. The glaucomatous eyes showed reductions of PERG amplitude that were directly related to the histologically defined nerve damage. VEP amplitudes were also reduced in the glaucomatous eyes, but were more variable and less affected by damage than the PERG responses. An acute increase in eye pressure to 40 mm Hg in eyes without damage had no detectable effect on PERG amplitudes.
New Serotonin 5-HT<sub>6</sub>Ligands from Common Feature Pharmacophore Hypotheses (2007)

Serotonin 5-HT6 receptor antagonists are thought to play an important role in the treatment of psychiatry, Alzheimer's disease, and probably obesity. To find novel and potent 5-HT6 antagonists and to provide a new idea for drug design, we used a ligand-based pharmacophore to perform the virtual screening of a commercially available database. A three-dimensional common feature pharmacophore model was developed by using the HipHop program provided in Catalyst software and was used as a query for screening the database. A recursive partitioning (RP) model which can separate active and inactive compounds was used as a filtering system. Finally a sequential virtual screening procedure (SQSP) was conducted, wherein both the common feature pharmacophore and the RP model were used in succession to improve the results. Some of the hits were selected based on druglikeness, ADME properties, structural diversity, and synthetic accessibility for real biological evaluation. The best hit compound showed a significant IC50 value of 9.6 nM and can be used as a lead for further drug development.
Protective effects of asiaticoside on sepsis-induced acute kidney injury in mice (2010)

Asiaticoside has protective effects against sepsis-induced acute kidney injury, which were probably associated with the inhibition of IL-6 in serum and iNOS protein in kidney tissues.
Hydrolysis of cisplatin—a first-principles metadynamics study (2010)

Cisplatin, or cis-[Pt(NH(3))(2)Cl(2)], was the first member of a new revolutionary class of anticancer drugs that is still used today for the treatment of a wide variety of cancers. The mode of action of cisplatin starts inside the cell with the hydrolysis of Pt-Cl bonds to form a Pt-aqua complex. The solvent environment plays an essential role in many biochemical processes in general, and is expected to have a particular strong effect on the activation (hydrolysis) of cisplatin and cisplatin derivatives. To investigate these solvent effects, we have studied the explicit solvent structures during cisplatin hydrolysis by means of Car-Parrinello molecular dynamics simulations. Since hydrolysis is an activated process, and thus a rare event on the simulation timescale, we have applied the metadynamics sampling technique to map out the free energy landscape from which the reaction mechanism and activation free energy are obtained. Our simulations show that hydrogen bonding between solvent water molecules and metal complexes in the hydrolyzed product systems is stronger than that in the reactant cisplatin system. In addition, the free energy profiles from our metadynamics simulations for the cisplatin hydrolysis shows that the second hydrolysis of cisplatin is thermodynamically favourable, which is in good agreement with experimental results and previous static density functional theory calculations. The reactant channels for both hydrolysis steps are rather wide and flat, indicative of a continuous spectrum of allowed mechanisms with no strong preference for either concerted dissociative or concerted associative pathways. Three or five coordinated metastable intermediates do not exist in aqueous solution.