gebhart/patrepeval huggingface dataset:
3D Printing of Buildings and Building Components as the Future of Sustainable Construction? (2016)

The paper presents the state-of-the-art concerning the current achievements in the field of 3D printing of buildings and building components. The 3D printing technologies, comparing to traditional techniques of constructing the buildings, could be considered as environmental friendly derivative giving almost unlimited possibilities for geometric complexity realizations. Two kinds of technologies were described in this paper with pointing to Contour Crafting as a promising technique that may be able to revolutionize construction industry in near future. Numerous advantages of this technology, such as reduction of the costs and time, minimizing the pollution of environment and decrease of injuries and fatalities on construction sites could be cited. Despite many advantages and hopes, some concerns are summarized in the conclusions, as the technology still has many limitations. A brief description of few examples of pioneering usage of 3D printing in construction industry are presented (Canal House in Amsterdam, WinSun company and printing application for building carried out by Skanska company). Creating a model that will be appropriate for 3D printers is possible in many different modelling programs. One of the most popular formats for sharing such models is STL format. In the paper sample models crated in Autodesk Inventor are shown, but also other tools suitable for preparing models for 3D printing are briefly discussed.
Surface Microscopy Characterizations of Large Size Graphene Films Grown by Surface Segregation on Ni and Transferred to Si/SiO2 Substrate (2009)

We report surface microscopy characterizations of large size graphene films (up to mm) grown on polycrystalline Ni foils and transferred to Si/SiO2. Wrinkles in such films are studied by both atomic force microscopy (AFM) and scanning tunneling microscopy (STM). Local graphitic lattice structures of the films are imaged with atomic-resolution STM and compared with those of the highly ordered pyrolytic graphite (HOPG).
Agent-based test-bed for road information systems (2012)

Road safety is one of the most important concerns of road authorities. In order to improve road safety, traffic managers develop traffic management and control strategies. The use of advanced traffic management systems is to support road managers in daily traffic management tasks. However, it is important to test in advance, the traffic strategies to evaluate the results and their suitability to the current situation. In this study, a test-bed based on multi-agent is presented. The purpose of this test-bed is to be able to test several traffic information strategies in case of adverse weather situations. It consists in a knowledge model implemented by a set of basic agents. These agents are easily configurable and extensible to aid in-depth research in this field. The test includes agents to control variable message signal, weather stations, data collection stations etc. The test-bed interface is based on Google maps providing a realistic environment that facilitates the implementation of the tested strategies in the real world.
Measurement of sensitivity of optical fibers for acoustic detection (1979)

Acoustically induced optical phase modulation has been measured in single-mode fibers over the acoustic frequency range of 100-1400 Hz. These results are compared to the predictions of a simple strain-optical model. An order of magnitude increase in sensitivity was found for plastic coated fibers.
Nonlinear Wheelset Dynamic Response to Random Lateral Rail Irregularities (1974)

The nonlinear equations of motion for a railway vehicle wheelset having profiled wheels and contact of the wheel flange with flexible rails are presented. The effects of spin creep and gyroscopic terms are included. The rails are considered to have random lateral irregularities which are described by prescribed power spectra. The equations of motion are integrated numerically and the effects on the dynamic response of quantities such as speed, track roughness, wheel wear, flange clearance, and lateral stiffness of the rails are investigated.
7-Dehydrocholesterol down-regulates cholesterol biosynthesis in cultured Smith-Lemli-Opitz syndrome skin fibroblasts (1998)

The Smith-Lemli-Opitz syndrome (SLOS) is a common birth defect-mental retardation syndrome caused by a defect in the enzyme that reduces 7-dehydrocholesterol to cholesterol. Because of this block, patients' plasma cholesterol levels are generally low while 7-dehydrocholesterol concentrations are markedly elevated. In addition, plasma total sterols are abnormally low and correlate negatively with the percent of 7-dehydrocholesterol (r = -0.65, P < 0.0001) suggesting that 7-dehydrocholesterol might inhibit the activity of HMG-CoA reductase. Cultured skin fibroblasts from SLOS patients grown in fetal bovine serum or for 1 day in delipidated medium contain little 7-dehydrocholesterol (3 +/- 1% of total sterols) and HMG-CoA reductase activities are indistinguishable from that measured in control cells. However, raising the 7-dehydrocholesterol concentration to 20 +/- 3% of total sterols, equal to the mean proportion in plasma of SLOS patients, by either growing cells for 1 week in delipidated medium or adding 20 microg/ml 7-dehydrocholesterol directly to the cells reduced HMG-CoA reductase activities from 74 +/- 7 to 9 +/- 2 pmol/min per mg protein, or from 92 +/- 22 to 16 +/- 4 pmol/min per mg protein, respectively (P < 0.01). In contrast, adding 20 microg/ml cholesterol evoked a 2- to 4-fold lesser suppression of activity (39 +/- 8 pmol/min per mg protein, P < 0.05, vs. 7-dehydrocholesterol). HMG-CoA synthase and LDL binding were inhibited equally by 7-dehydrocholesterol and cholesterol. Ketaconazole prevented the down-regulation of HMG-CoA reductase by 7-dehydrocholesterol, suggesting that an hydroxylated derivative of 7-dehydrocholesterol may be especially important in suppressing cholesterol synthesis. These results demonstrate that 7-dehydrocholesterol, perhaps as an hydroxylated derivative(s), is a very effective feedback inhibitor of HMG-CoA reductase.
Regulated Secretion in Platelets: Identification of Elements of the Platelet Exocytosis Machinery (1997)

To further characterize the molecular mechanisms of platelet function, we have sought to identify some of the proteins that mediate the secretory events of the platelet release reaction. We report that platelets contain the general elements of the membrane transport apparatus: N-ethylmaleimide sensitive fusion protein (NSF ), p115/transcytosis-associated protein (p115/TAP), and the soluble NSF attachment proteins (α- and, γ-SNAP). The cDNAs encoding two of these proteins, α- and γ-SNAP, have been cloned from a human platelet-derived cDNA library. Platelet membrane extracts possess SNAPreceptor (SNARE) activity, suggesting that the class of proteins (SNAREs) proposed to provide the specificity for vesicle docking and membrane fusion are present in platelets. To identify these proteins, we have used specific antibodies against known SNAREs to probe platelet extracts. Syntaxin 2 and 4 can be readily detected in platelet membrane preparations and are shown to participate in 20 S complex formation. Syntaxin 1, 3, and 5 could not be detected. Other known SNARE and SNARE-associated proteins such as vesicle-associated membrane protein (VAMP)/synaptobrevin 2, SNAP-25, synaptophysin, or synaptotagmin I could not be immunochemically detected in platelet membrane preparations. The presence of both the general transport proteins (NSF and SNAPs) and specific transport proteins (syntaxin 2 and 4) indicates that platelet exocytosis uses a molecular mechanism similar to other secretory cells such as neurons. However, the subcellular concentrations of these proteins suggest that, unlike neuronal secretion, granule-to plasma membrane docking may be the limiting step in platelet exocytosis.
Rapid and multi-step, patterned electrophoretic deposition of nanocrystals using electrodes covered with dielectric barriers (2014)

The rates of electrophoretic deposition (EPD) of CdSe nanocrystals (NCs) are approximately the same when powering electrodes on either the frontside or backside of thick dielectrics when the resistance of the NC colloid exceeds that of the dielectric barrier. Using electrodes with dielectric barriers enables conformal coverage over topography on the frontside. It also enables multistep processing when combined with powering patterned frontside electrodes for localized EPD. Powering patterned backside electrodes produces film features that are wider than the electrode dimensions, which is consistent with the results of modeling the electric field profile.
Benidipine Attenuates Glomerular Hypertension and Reduces Albuminuria in Patients with Metabolic Syndrome (2007)

Recent studies have shown that metabolic syndrome is associated with an increased risk for chronic kidney disease. We recently found that the prevalence of sodium-sensitive hypertension in patients with metabolic syndrome was significantly higher than that in patients with essential hypertension but without metabolic syndrome. We therefore assessed the effects of benidipine, a long-acting calcium channel blocker, on the sodium sensitivity of blood pressure and renal hemodymamics in 5 patients with metabolic syndrome. Glomerular hemodynamics were assessed using pressure-natriuresis curves, which were constructed by plotting the urinary excretion of sodium as a function of the mean arterial pressure, which was calculated as the mean of 48 values based on 24-h monitoring, during the intake of low (3 g NaCl daily) and relatively high (10 g NaCl daily) sodium diets. Under the relatively high sodium diet condition, benidipine significantly lowered systolic and diastolic blood pressure. The pressure-natriuresis curve was steeper after the administration of benidipine. Benidipine lowered glomerular capillary hydraulic pressure (P(GC)) levels (from 54.4+/-7.5 to 47.0+/-7.0 mmHg, p=0.0152) and reduced both the resistance of the afferent arterioles (from 10,338+/-2,618 to 9,026+/-2,627 dyn.s/cm5, p=0.047) and the resistance of the efferent arterioles (from 4,649+/-2,039 to 2,419+/-2,081 dyn.s/cm(5), p=0.003). The urinary albumin excretion rate also decreased after the administration of benidipine. These findings indicated that benidipine may be effective for reducing the risk of developing chronic kidney disease in patients with metabolic syndrome.
Protein denaturation induced by cyclic silicone (1997)

While it has been demonstrated that such low-molecular-weight cyclic silicones as octamethylcyclotetrasiloxane (D4) exhibit adjuvant activity, the mechanism of immunological response to silicone is still not clear. This study therefore used fluorescence and circular dichroism (CD) spectroscopy to investigate the denaturation and conformational change of two proteins, fibronectin (Fn) and fibrinogen (Fbg), induced by D4 in vitro. Incubating D4 with Fbg or Fn at D4-to-protein ratios of > 100 or for > 10 h yielded white and mould-like precipitates of the proteins, indicating massive denaturation and aggregation. The fact that the decrease in fluorescence intensity of D4-treated Fn and Fbg was accompanied by a red shift in the maximum wavelength also indicated that denaturation of the proteins had taken place. These changes in fluorescence might result from exposure of tryptophan residuals in the proteins to polar water molecules inasmuch as the denaturation would lead to changes in the tertiary structures of the proteins and rearrangement of the tryptophan residues. The loss of the tertiary structure leads to protein denaturation and, consequently, precipitation. The difference in CD spectra between control Fbg (or Fn) and D4-treated Fbg (or Fn) indicated conformational changes of the proteins when incubated with D4. Thus it has been demonstrated that D4 can induce denaturation and conformational changes in Fbg and Fn and it can be expected that protein molecules that have undergone denaturation or conformational change induced by D4 may act as antigens and stimulate the immune system to generate antibodies, ultimately resulting in autoimmune disease.
Profile guided management of code partitions for embedded systems (2004)

Researchers have proposed to divide embedded applications into code partitions and to download partitions on demand from a wireless code server to enable a diverse set of applications for very tightly constrained embedded systems. This paper describes a new approach for managing the request and storage of code partitions and we explore the benefits of our scheme.
Visual-conformal display format for helicopter guidance (2014)

Helicopter guidance in situations where natural vision is reduced is still a challenging task. Beside new available sensors, which are able to “see” through darkness, fog and dust, display technology remains one of the key issues of pilot assistance systems. As long as we have pilots within aircraft cockpits, we have to keep them informed about the outside situation. “Situational awareness” of humans is mainly powered by their visual channel. Therefore, display systems which are able to cross-fade seamless from natural vision to artificial computer vision and vice versa, are of greatest interest within this context. Helmet-mounted displays (HMD) have this property when they apply a head-tracker for measuring the pilot’s head orientation relative to the aircraft reference frame. Together with the aircraft’s position and orientation relative to the world’s reference frame, the on-board graphics computer can generate images which are perfectly aligned with the outside world. We call image elements which match the outside world, “visual-conformal”. Published display formats for helicopter guidance in degraded visual environment apply mostly 2D-symbologies which stay far behind from what is possible. We propose a perspective 3D-symbology for a head-tracked HMD which shows as much as possible visual-conformal elements. We implemented and tested our proposal within our fixed based cockpit simulator as well as in our flying helicopter simulator (FHS). Recently conducted simulation trials with experienced helicopter pilots give some first evaluation results of our proposal.
Analysis of the Quality and Utility of Random Shotgun Sequencing at Low Redundancies (1998)

The currently favored approach for sequencing the human genome involves selecting representative large-insert clones (100-200 kb), randomly shearing this DNA to construct shotgun libraries, and then sequencing many different isolates from the library. This method, entitled directed random shotgun sequencing, requires highly redundant sequencing to obtain a complete and accurate finished consensus sequence. Recently it has been suggested that a rapidly generated lower redundancy sequence might be of use to the scientific community. Low-redundancy sequencing has been examined previously using simulated data sets. Here we utilize trace data from a number of projects submitted to GenBank to perform reconstruction experiments that mimic low-redundancy sequencing. These low-redundancy sequences have been examined for the completeness and quality of the consensus product, information content, and usefulness for interspecies comparisons. The data presented here suggest three different sequencing strategies, each with different utilities. (1) Nearly complete sequence data can be obtained by sequencing a random shotgun library at sixfold redundancy. This may therefore represent a good point to switch from a random to directed approach. (2) Sequencing can be performed with as little as twofold redundancy to find most of the information about exons, EST hits, and putative exon similarity matches. (3) To obtain contiguity of coding regions, sequencing at three- to fourfold redundancy would be appropriate. From these results, we suggest that a useful intermediate product for genome sequencing might be obtained by three- to fourfold redundancy. Such a product would allow a large amount of biologically useful data to be extracted while postponing the majority of work involved in producing a high quality consensus sequence.
Stable single-frequency traveling-wave fiber loop laser with integral saturable-absorber-based tracking narrow-band filter (1995)

We demonstrate stable single-frequency and polarization operation of a traveling-wave, Er(3+)-doped fiber loop laser by incorporating an unpumped Er(+3)-doped fiber section butted against a narrow-band feedback reflector. The saturable absorber acts as a narrow bandpass filter that automatically tracks the lasing wavelength, thus ensuring single-frequency operation. Output powers up to 6.2 mW at 1535 nm were obtained for launched pump powers of 175 mW at 1064 nm. At this output, the relative intensity noise was less than -112 dBy/Hz at frequencies above 200 kHz and a laser linewidth of less than 0.95 kHz, whereas the lasing frequency was observed to drift slowly (~170 MHz/h) because of environmental effects.
Atlas of Laparoscopic Surgery (1996)

This atlas is composed of 28 chapters with authoritative commentaries and illustrations in a number of surgical procedures amenable to laparoscopic techniques. It is hoped that this atlas will simplify and organize surgical thought for the advanced laparoscopist
Fluorescence of Antiaromatic Systems:  An Experimental and Theoretical Study of 1,3,5-Tri-<i>tert</i>-butylpentalene (1998)

The fluorescence spectrum of 1,3,5-tri-tert-butylpentalene (TTBP), the stable derivative of antiaromatic pentalene, has been measured in solution at room and low temperature in condensed phase. A good correspondence between the first allowed absorption band and the fluorescence spectrum is observed. The fluorescence quantum yield of TTBP 2 × 10-4 M in cyclohexane is estimated to be ≈2 × 10-3 (λex = 313 nm) at room temperature. At low temperature and exciting at 355 nm, the fluorescence spectrum of TTBP shows appreciable vibronic structure. The fluorescence data have been related to the electronic structure of the parent molecule. MCSCF/CAS calculations for the ground and lowest excited states of pentalene, up to S4, have been performed in D2h symmetry with 3-21G and 6-31G basis sets including polarization and diffuse orbitals. As a result of the strong interaction between the pairs of states S0/S1 and S2/S3, the lowest component of each pair distorts from D2h to lower symmetry, giving rise to new equilibrium geometries. According to ab initio calculations, the observed fluorescence is assigned to upper state, S3 → S0, emission.
The Genome of Borrelia recurrentis, the Agent of Deadly Louse-Borne Relapsing Fever, Is a Degraded Subset of Tick-Borne Borrelia duttonii (2008)

In an effort to understand how a tick-borne pathogen adapts to the body louse, we sequenced and compared the genomes of the recurrent fever agents Borrelia recurrentis and B. duttonii. The 1,242,163-1,574,910-bp fragmented genomes of B. recurrentis and B. duttonii contain a unique 23-kb linear plasmid. This linear plasmid exhibits a large polyT track within the promoter region of an intact variable large protein gene and a telomere resolvase that is unique to Borrelia. The genome content is characterized by several repeat families, including antigenic lipoproteins. B. recurrentis exhibited a 20.4% genome size reduction and appeared to be a strain of B. duttonii, with a decaying genome, possibly due to the accumulation of genomic errors induced by the loss of recA and mutS. Accompanying this were increases in the number of impaired genes and a reduction in coding capacity, including surface-exposed lipoproteins and putative virulence factors. Analysis of the reconstructed ancestral sequence compared to B. duttonii and B. recurrentis was consistent with the accelerated evolution observed in B. recurrentis. Vector specialization of louse-borne pathogens responsible for major epidemics was associated with rapid genome reduction. The correlation between gene loss and increased virulence of B. recurrentis parallels that of Rickettsia prowazekii, with both species being genomic subsets of less-virulent strains.
Simultaneous Optimization of Forgetting Factor and Time-frequency Mask for Block Online Multi-channel Speech Enhancement (2019)

In this paper, we propose a block-online multi-channel speech enhancement technique which simultaneously optimizes time-frequency masks and forgetting factors for estimation of multichannel covariance matrices of the desired speech signal and the noise signal so as to maximize speech enhancement performance under the condition that environmental changes occur. The proposed method reduces the noise signal by using a multi-channel Wiener filter (MWF) which is generated by the covariance matrices with the estimated forgetting factors and the estimated time-frequency masks which are outputs of the proposed neural network. The proposed method learns all the parameters of the proposed neural network so as to maximize the speech enhancement performance. Three types of the input features for the forgetting factors adaptation are proposed. The first one is the magnitude spectral of the microphone input signal. The second one is the MWF output with the previous-block filter that is adapted in the previous block. The third one is the inner product between the microphone input signal and the estimated covariance matrices in the previous block. Experimental results show that the proposed method can reduce noise signal more accurately than the conventional equally weight sample averaging.
The mechanisms of inflammation in gout and pseudogout (CPP-induced arthritis) (2012)

Recent advances have stimulated new interest in the area of crystal arthritis, as microcrystals can be considered to be endogenous "danger signals" and are potent stimulators of immune as well as non-immune cells. The best known microcrystals include urate (MSU), and calcium pyrophosphate (CPP) crystals, associated with gout and pseudogout, respectively. Acute inflammation is the hallmark of the acute tissue reaction to crystals in both gout and pseudogout. The mechanisms leading to joint inflammation in these diseases involve first crystal formation and subsequent coating with serum proteins. Crystals can then interact with plasma cell membrane, either directly or via membrane receptors, leading to NLRP3 activation, proteolytic cleavage and maturation of pro-interleukin-1β (pro-IL1β) and secretion of mature IL1β. Once released, this cytokine orchestrates a series of events leading to endothelial cell activation and neutrophil recruitment. Ultimately, gout resolution involves several mechanisms including monocyte differentiation into macrophage, clearance of apoptotic neutrophils by macrophages, production of Transforming Growth Factor (TGF-β) and modification of protein coating on the crystal surface. This review will examine these different steps.
A green and secure authentication for the 4th generation mobile network (2011)

The 4th generation (4G) mobile access network and the core network are evolving towards a secure, fast, and Internet Protocol-based network. With the emergence of next generation battery-powered smart mobile phone and open source application platforms, security and the terminal's energy consumption have become big issues. Long Term Evolution (LTE) is one of the most popular 4G technologies defined by 3rd Generation Partnership Projects (3GPP). It is observed that the end user requires two authentication steps to access multimedia services. The first is the LTE network layer authentication, and the second is the IP Multimedia Subsystem (IMS) service layer authentication. The authentication steps utilize energy and are carried out using the Authentication and Key Agreement (AKA) protocol. This paper proposes an Improved AKA (I-AKA) authentication protocol which authenticates the user on both the network layer and the service layer without double execution the AKA protocol and simplifies the authentication steps. Furthermore, the security and energy consumption were analyzed and the results showed the proposed I-AKA could save up to 81.82% of the terminal's energy consumption related to authentication with increased security.