gebhart/patrepeval huggingface dataset:
DNA mutations associated with the human butyrylcholinesterase J-variant. (1992)

The J-variant of human serum butyrylcholinesterase (BChE) causes both an approximately two-thirds reduction of circulating enzyme molecules and a corresponding decrease in the level of BChE activity present in serum. Since the level of serum BChE activity and the duration of succinylcholine apnea are inversely correlated, this marked decrease in activity makes individuals with the J-variant more susceptible than usual subjects to prolonged apnea from succinylcholine. We reinvestigated the same family in which Garry et al. identified the J-variant phenotype. The atypical, fluoride, and K-variant mutations were also identified in members of the 47-person pedigree. DNA amplification by PCR, followed by direct sequencing of the amplified DNA, led to the finding that the J-variant phenotype of human serum BChE was associated with two DNA point mutations in the coding region. One of these was the mutation previously identified with the K-variant phenotype (GCA----ACA; Ala539----Thr). The other was an adenine-to-thymine transversion at nucleotide 1490, which changed amino acid 497 from glutamic acid to valine (GAA----GTA; Glu497----Val). This latter point mutation was named the J-variant mutation (formal name BCHE*497V). The J-variant mutation has not been identified without the K-variant mutation. The J-variant mutation created an RsaI-enzyme RFLP. Two additional point mutations, located in the noncoding regions of the gene, were also found to be linked with the J-variant and K-variant point mutations on the same allele. These noncoding polymorphic mutations had previously been found linked to the atypical and K-variant point mutations. A summary table shows dibucaine, fluoride, and Hoffmann-La Roche compound Ro 2-0683 inhibition numbers for 119 samples whose DNA has been sequenced. Eighteen BChE genotypes are represented.
Utility Fair Optimisation of Antenna Tilt Angles in LTE Networks (2013)

We formulate adaptation of antenna tilt angle as a utility fair optimisation task. This optimisation problem is non-convex, but in this paper we show that under reasonable conditions it can be reformulated as a convex optimisation. Using this insight, we develop a lightweight method for finding the optimal antenna tilt angles, making use of measurements which are already available at base stations, and suited to distributed implementation.
Application of Fluid-Attenuated Inversion Recovery pulse sequence in children with tuberous sclerosis. (2000)

To evaluate the application of Fluid-Attenuated Inversion Recovery (FLAIR) pulse sequence to increase the sensitivity of detecting tubers in tuberous sclerosis patients compared with fast spin-echo T2-weighted (FSET2W) image, we obtained 12 magnetic resonance (MR) images in 10 patients (mean age = 57.7 months old). Among the 12 examinations, 114 cortical and 128 subcortical tubers were revealed on the FLAIR images, whereas 54 and 72 tubers were found respectively on the FSET2W images. This may be due to the FLAIR pulse sequences remarkably attenuated CSF signals in comparison with the FSET2W images. However, FSET2W image delineated more subependymal nodules than FLAIR imaging did. Gd-DTPA enhanced T1W image is the most suitable pulse sequence to detect giant cell astrocytoma near the foramen of Monro. The results in cases of infants and little children were similar.
Direct measurement of structural forces between two surfaces in a nonpolar liquid (1981)

The force as a function of separation has been measured between two molecularly smooth surfaces immersed in the liquid octamethylcyclotetrasiloxane (OMCTS) whose molecules are quasispherical of diameter ∼1.0 nm. The force is an oscillatory function of distance, varying between attraction and repulsion, with a periodicity equal to the size of the liquid molecules to within the experimental resolution of ∼0.1 nm. The oscillations decay rapidly with distance: their measurable range is 6–10 molecular diameters and their magnitude exceeds that of conventional van der Waals forces at small distances. The magnitude of the oscillations is insensitive to changes in temperature, but sensitive to the chemical nature of the surfaces, and very sensitive to the presence of water. The results are considered, qualitatively, within the context of current theories of the liquid state near solid interfaces, and some implications for surface chemistry and colloid science are discussed.
Additive empirical force field for hexopyranose monosaccharides (2008)

We present an all-atom additive empirical force field for the hexopyranose monosaccharide form of glucose and its diastereomers allose, altrose, galactose, gulose, idose, mannose, and talose. The model is developed to be consistent with the CHARMM all-atom biomolecular force fields, and the same parameters are used for all diastereomers, including both the alpha- and beta-anomers of each monosaccharide. The force field is developed in a hierarchical manner and reproduces the gas-phase and condensed-phase properties of small-molecule model compounds corresponding to fragments of pyranose monosaccharides. The resultant parameters are transferred to the full pyranose monosaccharides, and additional parameter development is done to achieve a complete hexopyranose monosaccharide force field. Parametrization target data include vibrational frequencies, crystal geometries, solute-water interaction energies, molecular volumes, heats of vaporization, and conformational energies, including those for over 1800 monosaccharide conformations at the MP2/cc-pVTZ//MP2/6-31G(d) level of theory. Although not targeted during parametrization, free energies of aqueous solvation for the model compounds compare favorably with experimental values. Also well-reproduced are monosaccharide crystal unit cell dimensions and ring pucker, densities of concentrated aqueous glucose systems, and the thermodynamic and dynamic properties of the exocyclic torsion in dilute aqueous systems. The new parameter set expands the CHARMM additive force field to allow for simulation of heterogeneous systems that include hexopyranose monosaccharides in addition to proteins, nucleic acids, and lipids.
A Wind Energy Powered Wireless Temperature Sensor Node (2015)

A wireless temperature sensor node composed of a piezoelectric wind energy harvester, a temperature sensor, a microcontroller, a power management circuit and a wireless transmitting module was developed. The wind-induced vibration energy harvester with a cuboid chamber of 62 mm × 19.6 mm × 10 mm converts ambient wind energy into electrical energy to power the sensor node. A TMP102 temperature sensor and the MSP430 microcontroller are used to measure the temperature. The power management module consists of LTC3588-1 and LT3009 units. The measured temperature is transmitted by the nRF24l01 transceiver. Experimental results show that the critical wind speed of the harvester was about 5.4 m/s and the output power of the harvester was about 1.59 mW for the electrical load of 20 kΩ at wind speed of 11.2 m/s, which was sufficient to power the wireless sensor node to measure and transmit the temperature every 13 s. When the wind speed increased from 6 m/s to 11.5 m/s, the self-powered wireless sensor node worked normally.
Trocar Site Hernia (2004)

It is useful to clearly classify trocar site hernias to improve management of laparoscopic procedures.
Chronic intrathecal infusions after spinal cord injury cause scarring and compression (2001)

Intrathecal infusions are used in a number of rodent studies to deliver substances to the injured spinal cord. Whereas this method has been successful in certain paradigms, two potential limitations of this model have not been extensively reported: (1) scar formation at the catheter tip, which can lead to infusion failure, and (2) damage to the spinal cord caused by the catheter itself. Thus, the purpose of the present study was threefold: (1) to determine intrathecal infusion efficiency over 14 days following spinal cord injury; (2) to examine possible secondary damage caused by intrathecal tubing; and (3) to explore whether alternative protocols that avoid such damage are effective. Adult Fischer 344 rats were subjected to spinal cord lesions at T7, followed by placement of an intrathecal catheter attached to an Alzet minipump. Seven or 14 days following injury and catheter placement, tube patency was evaluated by diffusion of Evans Blue dye from the minipump. Results indicate that infusion was efficient 7 days following injury but was markedly reduced after 14 days. Further, histology and immunocytochemistry 14 days after injury demonstrated compression damage to the cord where the tubing rested. Alternative protocols, including intrathecal infusions through metal cannulae, or "drip" infusions directly over the lesion, did not improve delivery. These data suggest that results from rodent studies using infusion from catheters placed adjacent to lesion sites may be attributable to acute or subacute effects of the delivered substance. Future rodent studies using intrathecal infusions should include rigorous evaluation of infusion efficiency and possible secondary tissue damage.
3D synergistic imaging as an aid to image interpretation and surgical planning (1991)

The authors have developed four applications where registration of images from different modalities provides opportunities for synergism. By combining NR and SPECT images of the brain, it is possible to locate functional abnormalities indicated by SPECT with respect to the anatomy imaged by MR. This may provide opportunities for more precise surgery of functional lesions which are not visible in MR (such as certain types of epilepsy). The combination of MR and SPECT images of the heart enables heart function to be related to heart anatomy. Combining MR and CT images of the skull base region enables surgeons to more accurately relate bony anatomy visible in CT with soft tissue features most clearly visible in MR images, and hence aids planning of complicated surgical procedures such as transtemporal resections. Combining 3D reconstructions of blood vessels with MR soft tissue images provides surgeons with accurate information about the position of blood vessels, and hence may enable mortality and morbidity caused by accidental damage to blood vessels to be reduced.<
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From classical to quantum glass (1991)

We study the effects of a transverse magnetic field on the dynamics of the randomly diluted, dipolar coupled, Ising magnet ${\mathrm{LiHo}}_{0.167}$${\mathrm{Y}}_{0.833}$${\mathrm{F}}_{4}$. The transverse field mixes the eigenfunctions of the ground-state Ising doublet with the otherwise inaccessible excited-state levels. We observe a rapid decrease in the characteristic relaxation times, large changes in the spectral form of the relaxation, and a depression of the spin-glass transition temperature with the introduction of quantum fluctuations.
Common-Mode Current Due to a Trace Near a PCB Edge and Its Suppression by a Guard Band (2004)

The common-mode (CM) current due to a trace near a printed circuit board (PCB) edge, and its suppression by a guard band have been studied experimentally and with finite-difference time-domain (FDTD) modeling. As the guard band, copper tape is connected along the entire edge of the ground plane. First, a PCB electromagnetic interference (EMI) coupling path that results from the nonzero impedance of the PCB ground plane is discussed. As the trace is moved closer to the PCB edge, the CM current increases. Then, the effect of the guard band on the CM current is detailed. A guard band parallel to and near a trace is most effective in suppressing the CM current. The cross-sectional magnetic field distribution at center of the PCB with and without the guard band is also calculated with FDTD modeling. The guard band decreases the magnetic field distributed on the reverse side of a PCB. These results indicate the guard band is effective in suppressing CM current. Finally, an empirical formula to quantify the relationship between the position of a trace and CM current for the case with a guard band is proposed. Calculated results using the empirical formula and FDTD modeling are in good agreement, which indicates this empirical formula should be useful for developing EMI design guidelines.
Traffic intersection situation description ontology for advanced driver assistance (2011)

This work provides an approach to create a generic situation description for advanced driver assistance systems using logic reasoning on a traffic situation knowledge base. It contains multiple objects of different type such as vehicles and infrastructure elements like roads, lanes, intersections, traffic signs, traffic lights and relations among them. Logic inference is performed to check and extend the situation description and interpret the situation e. g. by reasoning about traffic rules. The capabilities of our ontological situation description approach are shown at the example of complex intersections with several roads, lanes, vehicles and different combinations of traffic signs and traffic lights. Real-time issues are discussed thereon.
Semantic-audio retrieval (2002)

This paper describes a system for connecting sounds and words in linked multi-dimensional vector spaces. The acoustic space is represented using anchor models and partitioned using agglomerative clustering. The semantic space is modeled by a hierarchical multinomial clustering model. Nodes in one space are linked by probabilistic models to the other space. With these linked models, users retrieve sounds with natural language, and the system describes new sounds with words.
Physical Status of Human Papillomavirus Integration in Cervical Cancer Is Associated with Treatment Outcome of the Patients Treated with Radiotherapy (2014)

Integration of human papillomavirus (HPV) DNA into the host genome is a critical aetiological event in the progression from normal cervix to intraepithelial neoplasm, and finally to invasive cervical cancer. However, there has been little work on how HPV integration status relates to treatment outcome for cervical carcinomas. In the current study, HPV E2 and E6 gene copy numbers were measured in 111 cervical cancer tissues using real-time QPCR. Integration patterns were divided into four groups: single copy-integrated with episomal components (group 1), single copy-integrated without episomal components (group 2), multicopy tandem repetition-integrated (group 3), and low HPV (group 4) groups. A relapse-predicting model was constructed using multivariable Cox proportional hazards model to classify patients into different risk groups for disease-free survival (DFS). The model was internally validated using bootstrap resampling. Oligonucleotide microarray analysis was performed to evaluate gene expression patterns in relation to the different integration groups. DFS rate was inferior in the order of the patients in group 4, group 2/3, and group 1. Multivariate analysis showed that histologic grade, clinical stage group, and integration pattern were significant prognostic factors for poor DFS. The current prognostic model accurately predicted the risk of relapse, with an area under the receiver operating characteristic curve (AUC) of 0.74 (bootstrap corrected, 0.71). In conclusion, these data suggest that HPV integration pattern is a potent prognostic factor for tailored treatment of cervical cancer.
Lactate and Lactate-to-Pyruvate Ratio in Critically Ill COVID-19 Patients: A Pilot Study (2022)

A limited number of coronavirus disease-19 (COVID-19) cases may require treatment in an intensive care unit (ICU). Arterial blood lactate levels are routinely measured in the ICU to estimate disease severity, predict poor outcomes, and monitor therapeutic handlings. A number of studies have suggested that, simultaneously with lactate, pyruvate should also be measured, providing augmented prognostic ability, and a better understanding of the underlying metabolic alterations in ICU patients. Hence, the aim of the present study was to elucidate the relationship between lactate levels and the lactate-to-pyruvate (LP) ratio with the clinical outcome in mechanically ventilated COVID-19 patients. Lactate and pyruvate were serially measured during the first 24 h of ICU stay. A group of ICU non-COVID-19 patients was used as a comparison group. The majority of COVID-19 patients (82.5%) had normal lactate levels and a normal LP ratio on ICU admission (normal metabolic pattern). A small, yet significant, percentage of patients had either elevated lactate levels or a high LP ratio (abnormal metabolic pattern); these patients exhibited a significantly higher risk of ICU mortality compared to the patients with a normal metabolic pattern (72.7% vs. 34.6%, <i>p</i> = 0.04). In our critically ill COVID-19 patients, elevated lactate levels or high LP ratios on admission to the ICU could be associated with poor clinical outcome.
Effect of postmenopausal hormonal replacement therapy on mammographic density and parenchymal pattern. (1995)

An increase in mammographic density was demonstrated in most subjects undergoing continuous combined HRT and was most pronounced in subjects with a lower baseline density percentage.
Body condition and pregnancy in northern Yellowstone elk: Evidence for predation risk effects? (2011)

S. Creel et al. reported a negative correlation between fecal progesterone concentrations and elk:wolf ratios in greater Yellowstone elk (Cervus elaphus) herds and interpreted this correlation as evidence that pregnancy rates of elk decreased substantially in the presence of wolves (Canis lupus). Apparently, the hypothesized mechanism is that decreased forage intake reduces body condition and either results in elk failing to conceive during the autumn rut or elk losing the fetus during winter. We tested this hypothesis by comparing age-specific body condition (percentage ingesta-free body fat) and pregnancy rates for northern Yellowstone elk, one of the herds sampled by Creel et al., before (1962-1968) and after (2000-2006) wolf restoration using indices developed and calibrated for Rocky Mountain elk. Mean age-adjusted percentage body fat of female elk was similarly high in both periods (9.0%-0.9% pre-wolf; 8.9%-0.8% post-wolf). Estimated pregnancy rates (proportion of females that were pregnant) were 0.91 pre-wolf and 0.87 post-wolf for 4-9 year-old elk (95% CI on difference = -0.15 to 0.03, P = 0.46) and 0.64 pre-wolf and 0.78 post-wolf for elk > 9 years old (95% CI on difference = -0.01 to 0.27, P = 0.06). Thus, there was little evidence in these data to support strong effects of wolf presence on elk pregnancy. We caution that multiple lines of evidence and/or strong validation should be brought to bear before relying on indirect measures of how predators affect pregnancy rates.
Treatment of airway mucus hypersecretion (2006)

Airway mucus hypersecretion is now recognized as a key pathophysiological feature in many patients with asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis. Consequently, it is important to develop drugs that inhibit mucus hypersecretion in these susceptible patients. Conventional therapies, including anticholinergics, ss2-adrenoceptor agonists, corticosteroids, mucolytics and macrolide antibiotics, have variable efficacy in inhibiting airway mucus hypersecretion, and are less effective in COPD than in asthma. Novel pharmacotherapeutic targets are being investigated, including inhibitors of nerve activity (e.g. large conductance calcium-activated potassium, BKCa, channel activators), tachykinin receptor antagonists, epoxygenase inducers (e.g. benzafibrate), inhibitors of mucin exocytosis (e.g. anti-myristoylated alanine-rich C kinase substrate (MARCKS), peptide and Munc-18B blockers), inhibitors of mucin synthesis and goblet cell hyperplasia (e.g. epidermal growth factor (EGF), receptor tyrosine kinase inhibitors, p38 mitogen-activated protein (MAP), kinase inhibitors, MAP kinase kinase/extracellular signal-regulated kinase (MEK/ERK), inhibitors, human calcium-activated chloride (hCACL2), channel blockers and retinoic acid receptor-a antagonists), inducers of goblet cell apoptosis (e.g. Bax inducers or Bcl-2 inhibitors), and purinoceptor P(2Y2) antagonists to inhibit mucin secretion or P(2Y2) agonists to hydrate secretions. However, real and theoretical differences delineate the mucus hypersecretory phenotype in asthma from that in COPD. More information is required on these differences to identify specific therapeutic targets which, in turn, should lead to rational design of anti-hypersecretory drugs for treatment of airway mucus hypersecretion in asthma and COPD.
Centi-pixel accurate real-time inverse distortion correction (2008)

Inverse distortion is used to create an undistorted image from a distorted image. For each pixel in the undistorted image it is required to determine which pixel in the distorted image should be used. However the process of characterizing a lens using a model such as that of Brown, yields a non-invertible mapping from the distorted domain to the undistorted domain. There are three current approaches to solving this: an approximation of the inverse distortion is derived from a low-order version of Brown's model; an initial guess for the distorted position is iteratively refined until it yields the desired undistorted pixel position; or a look-up table is generated to store the mapping. Each approach requires one to sacrifice either accuracy, memory usage or processing time. This paper shows that it is possible to have real-time, low memory, accurate inverse distortion correction. A novel method based on the re-use of left-over distortion characterization data is combined with modern numerical optimization techniques to fit a high-order version of Brown's model to characterize the inverse distortion. Experimental results show that, for thirty-two 5mm lenses exhibiting extreme barrel distortion, inverse distortion can be improved 25 fold to 0.013 pixels RMS over the image.
Implementation of an adaptive neural controller for sensory-motor coordination (1989)

A theory and prototype of a neural controller called INFANT, which learns sensory-motor coordination from its own experience, is presented. INFANT adapts to unforeseen changes in the geometry of the physical motor system and to the location, orientation, shape, and size of objects. It can learn to accurately grasp an elongated object without any information about the geometry of the physical sensory-motor system. INFANT relies on the self-consistency between sensory and motor signals to achieve unsupervised learning. It is designed to be generalized for coordinating any number of sensory inputs with limbs of any number of joints. INFANT is implemented with an image processor, stereo cameras, and a five-degree-of-freedom robot arm. After learning, its average position accuracy is within 3% of the length of the arm, and its orientation accuracy is within 60 degrees in solid angle.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>