gebhart/patrepeval huggingface dataset:
Spectroscopic and electrochemical characterization of nanostructured optically transparent carbon electrodes (2013)

The present paper describes the results related to the optical and electrochemical characterization of thin carbon films fabricated by spin coating and pyrolysis of AZ P4330-RS photoresist. The goal of this paper is to provide comprehensive information allowing for the rational selection of the conditions to fabricate optically transparent carbon electrodes (OTCE) with specific electrooptical properties. According to our results, these electrodes could be appropriate choices as electrochemical transducers to monitor electrophoretic separations. At the core of this manuscript is the development and critical evaluation of a new optical model to calculate the thickness of the OTCE by variable angle spectroscopic ellipsometry. Such data were complemented with topography and roughness (obtained by atomic force microscopy), electrochemical properties (obtained by cyclic voltammetry), electrical properties (obtained by electrochemical impedance spectroscopy), and structural composition (obtained by Raman spectroscopy). Although the described OTCE were used as substrates to investigate the effect of electrode potential on the real-time adsorption of proteins by ellipsometry, these results could enable the development of other biosensors that can be then integrated into various CE platforms.
Biomechanics of the knee joint: a critical review. (1993)

The literature concerning kinematic and kinetic studies on the knee joint is comprehensively reviewed in this article. Also reviewed are studies of etiology and operative treatment of injury, as well as chronic disease such as dislocation, arthritis, and ligamentous rupture. This paper formulates experimental study and mathematical model analysis of the tibio-femoral and patello-femoral joints, respectively. The sections on experimental study cover the following: the tibio-femoral joint including load bearing capacity, knee laxity, ligamentous strain, articular geometry, and multiaxial movement; the patello-femoral joint including forces and stresses and patellar tracking patterns. Further, three items, considered as future problems, are discussed briefly: individual variations in material properties of the soft tissue and biphasic cartilage-bone structures, quantitative description of bone geometry, and quantitative determination of extreme tensions and distortions in connective tissues surrounding the knee.
Visualization of Knowledge Structures (2007)

In this article, visual concept explorer (VCE), a concept mapping tool, is introduced and its design principles are described. VCE creates dynamic concept maps for the user and facilitates user's visual interaction to concepts and documents. Its central idea is to make implicit knowledge structures explicit. As an example of practical knowledge mapping application, VCE has characteristics of both information visualization and knowledge visualization.
Evaluation of Optimized Digital Fundus Reflex Photographs for Lens Opacities in the Age-Related Eye Disease Study 2: AREDS2 Report 7 (2013)

Digital grading using fundus reflex images with image enhancing tools has reproducibility comparable to film-based retroillumination images, and may be useful for centralized objective lens opacity assessment in clinical trials using widely available fundus cameras. Red reflex images limit evaluation to cortical and PSC opacities, and do not permit assessment of nuclear opacities. (ClinicalTrials.gov number, NCT00345176.).
「後殖民」的政治曖昧性(The political ambiguity of “post-colonial”) (2007)

「後殖民(post-colonial)」是在80年代西方學術界繼「後現代(post-modern)」、「後結構主義(post-structuralism)」等的「後」理論浪潮中湧現的術語。現在世界上大部份人也生活在殖民主義(colonialism)之後，因此「後殖民」也很「理所當然的(naturalized)」，一般被單一化區別(universalizing category) 與分割在殖民主義之外。在世界各地獨立聲中，「後殖民」也漸漸轉化成「第三世界」的「前殖民地(ex-colonies)」的政治環境統稱。廣義上，「後殖民」指在殖民時期之「後(after)」，尤其是指在第二次世界大戰後擺脫殖民統治獨立的第三世界國家。它隱含著這些經過了西方歐洲白人中心，在地域上作政治及軍事統治的第三世界社會的黑暗時代要結束，走向自由獨立，美好光明的「後殖民」新紀元。當中「殖民」與「後殖民」的關係，往往被聯想成一種有因果關係的線性歷史觀。
Phage display as a tool to discover blood–brain barrier (<scp>BBB</scp>)‐shuttle peptides: panning against a human <scp>BBB</scp> cellular model (2016)

Most potential drugs for the treatment of central nervous system disorders do not cross the blood-brain barrier (BBB). Much research effort has been devoted to the discovery of new BBB-shuttle peptides-most of which have been identified by phage display. Here we report for the first time on the use of phage display against a human BBB cellular model which mimics the characteristics of the BBB. From the panning experiment of a 12-mer library, the SGVYKVAYDWQH (SGV) peptide sequence was selected and its permeability validated in the aforementioned model. Furthermore, internalization studies suggested that SGV internalizes through a clathrin-mediated mechanism and that it increases the uptake of a cargo in endothelial cells. These results highlight the usefulness of in vitro BBB models for the discovery of BBB-shuttle peptides through phage display libraries.
The Preliminary Study of the Application of Traditional Chinese Medicine Theory in Economics (2006)

This article summaries the concept of essence,qi and spirit in traditional Chinese medical science,and combining with economics,puts forward the concept of essence,qi and spirit in a enterprise.It divides the main functional departments in the enterprise into five zones according to the theory of wuxing,and with the method of foster and restrain of wu xing,analyzes the interdependence and mutual-restriction in each functional zone.
Nuclear magnetic resonance of biological macromolecules (2001)

Identification and optimization of protein domains for NMR studies In-cell NMR spectroscopy Molecular Fragment Replacement Approach to Protein Structure Determination by Chemical Shift and Dipolar Homology Database Mining Cross-correlated relaxation for structure and dynamics Rapid NMR Data Collection An Integrated Platform for Automated Analysis of Protein NMR Structures Rapid Assessment of Protein Structural Stability and Fold Validation via NMR Determination of Protein Backbone Structures from Residual Dipolar Couplings Robotic Cloning and Protein Production Platform of the Northeast Structural Genomics Consortium Protein Structure Estimation From Minimal Restraints Using Rosetta Protein Structure Elucidation From Minimal Data: The CLOUDS and ABACUS Approaches Elucidation of the Protein Folding Landscape by NMR Membrane Protein Preparation for TROSY NMR Screening Solution structure and dynamics of integral membrane proteins by NMR: a case study involving the enzyme PagP NMR Experiments on Aligned Samplet of Membrane Proteins NMR techniques used with very large biological macromolecules in solution Structure determination of large biological RNAs Hydrodynamic Models and Computational Methods for NMR relaxation Solution NMR Spin Relaxation Methods for Characterizing Chemical Exchange in High Molecular Weight Systems Isotropic Reorientational Eigenmode Dynamics Complements NMR Relaxation Measurements for RNA NMR techniques for identifying the interface of a larger protein-protein complex: cross and transferred cross-saturation experiments Enzyme Dynamics During Catalysis Measured by NMR Spectroscopy Structure determination of protein/RNA complexes by NMR Utilization of NMR-derived fragment leads in drug design Discovery of Ligands by a Combination of Computational and NMR-based Screening: RNA as an Example Target
Huge Splenic Pseudoaneurysm Complicated from Surgery for Pancreatitis: Report of a Case (2005)

A bleeding pseudoaneurysm of a visceral artery is a rare but potentially lethal complication of acute or chronic pancreatitis, with a high mortality rate if left untreated. Current modalities for management of bleeding pseudoaneurysm include transarterial embolization by interventional radiology or surgical resection. Herein we present a case of alcoholic pancreatitis complicated with splenic artery pseudoaneurysm with the symptom of sudden onset of abdominal pain. The case was successfully managed with aneurysmectomy, distal pancreatectomy and splenectomy. The patient remained asymptomatic until four years later when he presented with a similar episode of acute pancreatitis.
An adaptive antenna for spatial-domain path-diversity (2002)

High-speed TDMA mobile communications suffer from frequency-selective fading due to multipath propagation. Also, the energy per bit is lower because the symbol duration is short. We need a scheme which reduces the frequency-selective fading and utilizes transmitted power efficiently. This paper presents a new configuration of an adaptive antenna for path-diversity in high-speed mobile communications. The adaptive antenna has several weight vectors which resolve multipath signals in the spatial-domain. The resolved multipath signals are combined equalizing the delay difference. Thus, the frequency-selective fading is suppressed and we can utilize the signal power efficiently. We carried out computer simulations under several scenarios. It is shown that the proposed adaptive antenna reveals a good path-diversity performance.
Compartmentalization of the Protease-antiprotease Balance in Early Severe Acute Pancreatitis (2005)

In patients with early severe acute pancreatitis, there is a significant trypsinogen activation resulting in protease-antiprotease imbalance and thereby free enzymatically active trypsin in the 2 body fluid compartments in close vicinity to the inflammatory process. This may be involved in the pathophysiology of local and distant tissue damage.
Investigating effects of visual and tactile feedback on spatial coordination in collaborative handheld systems (2012)

Mobile and handheld devices have become platforms to support remote collaboration. But, their small form-factor may impact the effectiveness of the visual feedback channel often used to help users maintain an awareness of their partner's activities during synchronous collaborative tasks. We investigated how visual and tactile feedback affects collaboration on mobile devices, with emphasis on spatial coordination in a shared workspace. From two user studies, our results highlight different benefits of each feedback channel in collaborative handheld systems. Visual feedback can provide precise spatial information for collaborators, but degrades collaboration when the feedback is occluded, and sometimes can distract the user's attention. Spatial tactile feedback can reduce the overload of information in visual space and gently guides the user's attention to an area of interest. Our results also show that visual and tactile feedback can complement each other, and systems using both feedback channels can support better spatial coordination than systems using only one form of feedback.
Parallel multi-delay simulation (1993)

The multi-delay parallel (MDP) technique is a multi-delay logic simulation algorithm that uses no event-sorting mechanism. Wide bit-fields and bit-parallel operations are used to resolve out-of-order events. Although the MDP technique was designed to be implemented in hardware, the software version has proven to be competitive with ordinary multi-delay simulation. Two versions of the MDP technique are presented: fixed alignment and variable alignment. The fixed alignment algorithm uses bit-fields that are wide enough to capture any event that could occur during the simulation, while the variable alignment algorithm uses a minimum-width bit field.
Diamide Inhibitors of the <i>Bacillus subtilis</i> <i>N</i>-Acetylglucosaminidase LytG That Exhibit Antibacterial Activity (2017)

N-Acetylglucosaminidases (GlcNAcases) play an important role in the remodeling and recycling of bacterial peptidoglycan by degrading the polysaccharide backbone. Genetic deletions of autolysins can impair cell division and growth, suggesting an opportunity for using small molecule autolysin inhibitors both as tools for studying the chemical biology of autolysins and also as antibacterial agents. We report here the synthesis and evaluation of a panel of diamides that inhibit the growth of Bacillus subtilis. Two compounds, fgkc (21) and fgka (5), were found to be potent inhibitors (MIC 3.8 ± 1.0 and 21.3 ± 0.1 μM, respectively). These compounds inhibit the B. subtilis family 73 glycosyl hydrolase LytG, an exo GlcNAcase. Phenotypic analysis of fgkc (21)-treated cells demonstrates a propensity for cells to form linked chains, suggesting impaired cell growth and division.
Self‐Assembly of Porphyrin‐Centered Amphiphilic Star Block Copolymer into Polymeric Vesicular Aggregates (2003)

Abstract Polymeric vesicular aggregates with spherical and tubular shapes were formed from the self‐assembly of a porphyrin‐centered amphiphilic star poly(oxazoline) [poly(phenyloxazoline)‐ block ‐poly(methyloxazoline)] in an DMF/water mixture containing excess DMF. The aggregates were evaluated by means of UV‐Vis, fluorescent, 1 H NMR spectroscopies, and optical microscopy. The driving force to induce the vesicular aggregates is the interactions between poly(phenyloxazoline) segments which were insoluble in DMF rich aqueous medium. Polymeric vesicular aggregates with spherical and tubular shapes were formed from the self‐assembly of a porphyrin‐centered amphiphilic star poly(oxazoline) [poly(phenyloxazoline)‐ block ‐poly(methyloxazoline)] in an DMF/water mixture. image Polymeric vesicular aggregates with spherical and tubular shapes were formed from the self‐assembly of a porphyrin‐centered amphiphilic star poly(oxazoline) [poly(phenyloxazoline)‐ block ‐poly(methyloxazoline)] in an DMF/water mixture.
Robustness to laser frequency offset in direct-detection dpsk and dqpsk systems (2003)

We assess, both by measurement and simulation, the receiver performance degradation caused by frequency offsets between the optical source and the delay interferometer for nonreturn-to-zero (NRZ) and return-to-zero (RZ) differential-phase-shift-keying (DPSK) and differential-quadrature-phase-shift-keying (DQPSK) systems. We find that NRZ- and RZ-DQPSK systems are about six times more sensitive to frequency offsets than NRZ- and RZ-DPSK systems operating at the same bit rate. We explain the reason for this behavior by means of eye aperture considerations.
RNA Structural Elements of Hepatitis C Virus Controlling Viral RNA Translation and the Implications for Viral Pathogenesis (2012)

Hepatitis C virus (HCV) genome multiplication requires the concerted action of the viral RNA, host factors and viral proteins. Recent studies have provided information about the requirement of specific viral RNA motifs that play an active role in the viral life cycle. RNA regulatory motifs controlling translation and replication of the viral RNA are mostly found at the 5' and 3' untranslated regions (UTRs). In particular, viral protein synthesis is under the control of the internal ribosome entry site (IRES) element, a complex RNA structure located at the 5'UTR that recruits the ribosomal subunits to the initiator codon. Accordingly, interfering with this RNA structural motif causes the abrogation of the viral cycle. In addition, RNA translation initiation is modulated by cellular factors, including miRNAs and RNA-binding proteins. Interestingly, a RNA structural motif located at the 3'end controls viral replication and establishes long-range RNA-RNA interactions with the 5'UTR, generating functional bridges between both ends on the viral genome. In this article, we review recent advances on virus-host interaction and translation control modulating viral gene expression in infected cells.
Coordinating Strategic Capacity Planning in the Semiconductor Industry (2003)

We study strategic capacity planning in the semiconductor industry. Working with a major US semiconductor manufacturer on the configuration of their worldwide production facilities, we identify two unique characteristics of this problem as follows: (1) wafer demands and manufacturing capacity are both main sources of uncertainty, and (2) capacity planning must consider the distinct viewpoints from marketing and manufacturing. We formulate a multi-stage stochastic program with demand and capacity uncertainties. To reconcile the marketing and manufacturing perspectives, we consider a decomposition of the planning problem resembling decentralized decision-making. We develop recourse approximation schemes representing different decentralization schemes, which vary in information requirements and complexity. We show that it is possible to arrive at near optimal solutions (within 6.5%) with information decentralization while using a fraction (16.2%) of the computer time.
CD8 T cell responses to live, viral Yellow fever vaccine in humans (2008)

Yellow Fever virus 17D (YFV‐17D) is a live attenuated vaccine that generates long‐lasting protective immunity. It provides an invaluable model to study CD8 T cell differentiation in a primary, acute viral infection in humans. Using a comprehensive peptide library spanning the viral polyprotein, we report an analysis of the YFV‐17D specific primary CD8 T cell response in vaccinated subjects. The largest proteins NS3, NS5 and Env accounted for the majority of the response. Identification of an immunodominant HLA‐0201 restricted CD8 T cell epitope enabled longitudinal phenotypic and functional analysis of antigen specific CD8 T cells in response to YFV‐17D. Effector CD8s seen as early as 11 days post vaccination till as late as 21 days upregulated proliferation (Ki‐67) and activation (HLA‐DR, CD38) markers and acquired cytolytic molecules like granzyme B. These markers were downregulated by day 30 after which a contraction of tetramer specific cells was seen. In short‐term in vitro stimulations of PBMCs with peptide, antigen experienced CD8 T cells were capable of producing cytokines like IFNγ, TNFα and IL‐2, chemokines like Mip‐1β and showed degranulation indicating that the vaccine elicits a polyfunctional CD8 response similar to vaccinia, another successful live viral vaccine. Evaluating the quality of the response may reveal the immune mechanisms responsible for an effective vaccine.
Oxidative stress and mitochondrial damage: importance in non-SOD1 ALS (2015)

It is well known that mitochondrial damage (MD) is both the major contributor to oxidative stress (OS) (the condition arising from unbalance between production and removal of reactive oxygen species) and one of the major consequences of OS, because of the high dependance of mitochondrial function on redox-sensitive targets such as intact membranes. Conditions in which neuronal cells are not able to cope with MD and OS seem to lead or contribute to several neurodegenerative diseases including Amyotrophic Lateral Sclerosis (ALS), at least in the most studied superoxide dismutase 1 (SOD1)-linked genetic variant. As summarized in this review, new evidence indicates that MD and OS play a role also in non-SOD1 ALS and thus they may represent a target for therapy despite previous failures in clinical trials.
Cleaning of dairy HTST plate heat exchangers: comparison of single‐ and two‐stage procedures (1987)

A bench‐scale tubular heat exchanger and a pilot‐scale plate heat exchanger have been used to compare the effectiveness of a single‐stage with the traditional two‐stage procedure for the removal of milk deposits from heated surfaces. The use of a single‐stage detergent has been shown to produce both physically and chemically clean surfaces in half the time taken by the two‐stage, alkali‐acid procedure which did not remove completely calcium deposits.
Recurrent Neural Network Attention Mechanisms for Interpretable System Log Anomaly Detection (2018)

Deep learning has recently demonstrated state-of-the art performance on key tasks related to the maintenance of computer systems, such as intrusion detection, denial of service attack detection, hardware and software system failures, and malware detection. In these contexts, model interpretability is vital for administrator and analyst to trust and act on the automated analysis of machine learning models. Deep learning methods have been criticized as black box oracles which allow limited insight into decision factors. In this work we seek to bridge the gap between the impressive performance of deep learning models and the need for interpretable model introspection. To this end we present recurrent neural network (RNN) language models augmented with attention for anomaly detection in system logs. Our methods are generally applicable to any computer system and logging source. By incorporating attention variants into our RNN language models we create opportunities for model introspection and analysis without sacrificing state-of-the art performance. We demonstrate model performance and illustrate model interpretability on an intrusion detection task using the Los Alamos National Laboratory (LANL) cyber security dataset, reporting upward of 0.99 area under the receiver operator characteristic curve despite being trained only on a single day's worth of data.
Chemistry of organosilicon compounds. 109. trans- and cis-1,2-Dimethyl-1,2-diphenyldisilene. Is Silicon:silicon a true double bond? (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemistry of organosilicon compounds. 109. trans- and cis-1,2-Dimethyl-1,2-diphenyldisilene. Is Silicon:silicon a true double bond?Hideki Sakurai, Yasuhiro Nakadaira, and Toshiaki KobayashiCite this: J. Am. Chem. Soc. 1979, 101, 2, 487–488Publication Date (Print):January 1, 1979Publication History Published online1 May 2002Published inissue 1 January 1979https://pubs.acs.org/doi/10.1021/ja00496a039https://doi.org/10.1021/ja00496a039research-articleACS PublicationsRequest reuse permissionsArticle Views146Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts