gebhart/patrepeval huggingface dataset:
Effective Quality of Service Differentiation for Real-world Storage Systems (2010)

Data storage is an integral part of IT infrastructures, where Quality of Service (QoS) differentiation amongst customers and their applications is essential for many. Achieving this objective in a production environment is nontrivial, because these environments are complex and dynamic. Numerous practical and engineering constraints render the task even more challenging. This paper presents SLED-2, a QoS differentiation solution that meets these challenges in offering effective protection to the performance of important workloads at the expense of less important workloads when needed. SLED-2 uses a customized feedback heuristic that rate-limits selected I/O streams. This approach is unique in that it accounts for a number of important practical considerations, including fine-grained controls, errors in storage systems models, and inexpensive and safe QoS management. SLED-2 has been implemented for the IBM DS8000 series storage servers and shown to be highly effective in a set of hostile and practical scenarios using test facilities for IBM storage products.
Authenticating User Using Keystroke Dynamics and Finger Pressure (2009)

Now mobile devices are developed to serve various functions, storing the sensitive information. As a consequence, the authentication of users for mobile devices has become an important issue. Additionally, the development of the mobile system is moving forward to the touch screen system for user friendly and quick access mechanism. In this paper, we proposed behavioral manners of users over the touch pad acting like touch screen that is able to detect finger pressure. We study the potential of each biometrics behavioral by individual and couple, comprise with hold-time, inter-key and finger pressure. The finding has shown that, the finger pressure gives the discriminative information more than keystroke dynamics with the PNN analytical method. Moreover, using only the finger pressure produces high accuracy rate of 99%.
Berberine Targets Assembly of Escherichia coli Cell Division Protein FtsZ (2008)

The ever increasing problem of antibiotic resistance necessitates a search for new drug molecules that would target novel proteins in the prokaryotic system. FtsZ is one such target protein involved in the bacterial cell division machinery. In this study, we have shown that berberine, a natural plant alkaloid, targets Escherichia coli FtsZ, inhibits the assembly kinetics of the Z-ring, and perturbs cytokinesis. It also destabilizes FtsZ protofilaments and inhibits the FtsZ GTPase activity. Saturation transfer difference NMR spectroscopy of the FtsZ-berberine complex revealed that the dimethoxy groups, isoquinoline nucleus, and benzodioxolo ring of berberine are intimately involved in the interaction with FtsZ. Berberine perturbs the Z-ring morphology by disturbing its typical midcell localization and reduces the frequency of Z-rings per unit cell length to half. Berberine binds FtsZ with high affinity ( K D approximately 0.023 microM) and displaces bis-ANS, suggesting that it may bind FtsZ in a hydrophobic pocket. Isothermal titration calorimetry suggests that the FtsZ-berberine interaction occurs spontaneously and is enthalpy/entropy-driven. In silico molecular modeling suggests that the rearrangement of the side chains of the hydrophobic residues in the GTP binding pocket may facilitate the binding of the berberine to FtsZ and lead to inhibition of the association between FtsZ monomers. Together, these results clearly indicate the inhibitory role of berberine on the assembly function of FtsZ, establishing it as a novel FtsZ inhibitor that halts the first stage in bacterial cell division.
A microwell array cytometry system for high throughput single cell biology and bioinformatics (2009)

Thesis (Ph. D.)--Harvard-MIT Division of Health Sciences and Technology, 2009.
MECHANISMS OF VOLATILE SULFUR COMPOUND AND ODOR PRODUCTION IN DIGESTED BIOSOLIDS (2003)

MECHANISMS OF VOLATILE SULFUR COMPOUND AND ODOR PRODUCTION IN DIGESTED BIOSOLIDSOdors produced from biosolids has become an increasing problem and often cited as a significant concern of many treatment plant operations. Recent research has shown that most odors are associated with volatile sulfur compounds (VSCs), especially methanethiol (MT), dimethyl sulfide (DMS) and dimethyl disulfide (DMDS); however, little research has been performed to understand the mechanisms of VSC...Author(s)Matthew J. HigginsDouglas P. YaroszYen-Chih ChenSudhir N. MurthyN.A. MassJ.R. CooneySourceProceedings of the Water Environment FederationSubjectSession 13 Odor Issues and PerspectivesDocument typeConference PaperPublisherWater Environment FederationPrint publication date Jan, 2003ISSN1938-6478SICI1938-6478(20030101)2003:1L.993;1-DOI10.2175/193864703784292926Volume / Issue2003 / 1Content sourceResiduals and Biosolids ConferenceFirst / last page(s)993 - 805Copyright2003Word count245
Integrating global wireless systems with IP (2002)

We propose several algorithms for total IP based wireless networks. This includes any cellular system from TDMA, GSM to CDMA. Solutions for associated improvements come with the new architecture are also discussed. One area is the IP internetworking among different cellular systems (GSM to GSM, GSM to CDMA, TDMA to GSM). First, an easy and fast mean of deploying a total wireless IP network (including backhaul and core) is presented. Our solution is technology independent (TDMA, GSM, CDMA) and has minimum impact on the existing network. With this proposal, the signaling is done through existing PLMN and limited IP based standard protocols. This is a pure packet based network and can support both data and voice. The mapping of PLMN and IP based addressing is through HLR to translate phone number based address (MIN) to IP based address. The PLMN provides services as ISP to support dynamic IP. For VPN application, the HLR and HLR can do the first level authentication. The e2e authentication is carried out between the mobile terminal and server. Second, the wireless vocoding based IP vocoder standards are discussed to further integrate the wireless with the IP network. Third, the solution for IP interworking of single technology global markets (European GSM) are presented. Fourth, the solution for IP interworking of multiple technologies global markets are presented. Fifth, the one step vocoding conversion for inter-system (GSM to/from CDMA) is discussed.
Practice Notes: Strategies in Health Education (2004)

The Practice Notes section is intended to keep readers informed about health education practice around the country. It is an attempt to spread the word about exemplary strategies, initiatives, and programs and share successes in overcoming obstacles or challenges. Periodically, articles presenting perspectives on practice-related issues are also included in Practice Notes.
Alzheimer's disease amyloid hypothesis at crossroads: where do we go from here? (2010)

Alzheimer's disease has been the focus of several drug discovery approaches by the pharmaceutical industry. Four drug candidates coming out of such efforts have recently failed in late-stage clinical trials for lack of efficacy or safety concerns. These drugs were designed based on the presently dominant scientific hypothesis for Alzheimer's disease called the 'amyloid hypothesis'. This editorial will briefly review the failure of these drugs and the effect of this on the amyloid hypothesis. Rather than accept the status quo, this editorial suggests a revised version of this hypothesis to reconcile data from recent drug failures. We propose a two-phase disease process; a first phase that is independent of amyloid and a second robust phase dependent on the amyloid cascade. Further validation of this revised hypothesis could aid future drug discovery for this devastating disease.
MOCVD grown AlGaN/AlN/GaN HEMT structure with compositionally step-graded AlGaN barrier layer (2006)

Unintentionally doped AlGaN/AlN/GaN high electron mobility transistor (HEMT) structures with compositionally step-graded AlGaN barrier layer were grown on sapphire substrates by metalorganic chemical vapor deposition (MOCVD). The HEMT structure exhibited typical two-dimensional electron gas (2DEG) mobility of 1600cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> /Vs at room temperature and 6412cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> /Vs at 79K with almost equal 2DEG concentration of 1.0times10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">13</sup> /cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . The 50mm HEMT wafer exhibited an average sheet resistance of 318.0Omega/square, with a good resistance uniformity of 0.89%. Atomic force microscopy (AFM) measurements revealed a smooth AlGaN surface with root-mean-square roughness (RMS) of 0.199nm and 0.295nm for scan area of 2mumtimes2mum and 5mumtimes5mum, respectively. A combined using of compositionally step-graded AlGaN barrier structure and AlN interlayer results in the high electrical performance and smooth surface of this heterostructure
A score test for the linkage analysis of qualitative and quantitative traits based on identity by descent data from sib-pairs (2000)

We propose a general likelihood-based approach to the linkage analysis of qualitative and quantitative traits using identity by descent (IBD) data from sib-pairs. We consider the likelihood of IBD data conditional on phenotypes and test the null hypothesis of no linkage between a marker locus and a gene influencing the trait using a score test in the recombination fraction theta between the two loci. This method unifies the linkage analysis of qualitative and quantitative traits into a single inferential framework, yielding a simple and intuitive test statistic. Conditioning on phenotypes avoids unrealistic random sampling assumptions and allows sib-pairs from differing ascertainment mechanisms to be incorporated into a single likelihood analysis. In particular, it allows the selection of sib-pairs based on their trait values and the analysis of only those pairs having the most informative phenotypes. The score test is based on the full likelihood, i.e. the likelihood based on all phenotype data rather than just differences of sib-pair phenotypes. Considering only phenotype differences, as in Haseman and Elston (1972) and Kruglyak and Lander (1995), may result in important losses in power. The linkage score test is derived under general genetic models for the trait, which may include multiple unlinked genes. Population genetic assumptions, such as random mating or linkage equilibrium at the trait loci, are not required. This score test is thus particularly promising for the analysis of complex human traits. The score statistic readily extends to accommodate incomplete IBD data at the test locus, by using the hidden Markov model implemented in the programs MAPMAKER/SIBS and GENEHUNTER (Kruglyak and Lander, 1995; Kruglyak et al., 1996). Preliminary simulation studies indicate that the linkage score test generally matches or outperforms the Haseman-Elston test, the largest gains in power being for selected samples of sib-pairs with extreme phenotypes.
Modeling temporal asymmetry in the auditory system (1998)

Sound sources in the environment produce waves that are almost invariably asymmetric in time, and human listeners are highly sensitive to temporal asymmetry. The spectral analysis and neural transduction processes in the cochlea enhance temporal asymmetry, as do time-domain models of cochlear processes, but it appears that the resulting asymmetry is not sufficient to explain the observed perceptual asymmetry. In the auditory image model (AIM) of hearing, the temporal asymmetry in the neural activity produced by the cochlea is further enhanced by the "strobed" temporal integration that converts the neural activity pattern into an auditory image, and the temporal asymmetry in the auditory image is sufficient to explain the perceptual asymmetry. Modern versions of the "duplex model" of pitch have time-domain cochlea simulations that produce neural activity with temporal asymmetry similar to that produced by AIM. In the final stage, however, they apply autocorrelation to the neural pattern and autocorrelation is a symmetric process in time. In this paper the effect of autocorrelation on temporal asymmetry is examined in a range of auditory models with varying forms of auditory filterbank, compression, and neural transduction. It is concluded that autocorrelation does not enhance temporal asymmetry and often reduces it, and that autocorrelogram models cannot explain the magnitude of the perceptual asymmetry in their current form. Then, the original version of strobed-temporal-integration is reviewed with regard to temporal asymmetry, and the delta-gamma theory of temporal asymmetry [Irino and Patterson, J. Acoust. Soc. Am. 99, 2316-2331 (1996)] is used to develop a new version of strobed-temporal-integration that is more robust and physiologically more plausible.
An Enhanced Authenticated Key Agreement Protocol with a Neural Network-based Model for Joining-Phase in Mobile Environments (2011)

International audience
Modular Redox‐Active Inorganic Chemical Cells: iCHELLs (2011)

Cell within a cell: Interfacial membrane formation by cation exchange of polyoxometalates produces modular inorganic chemical cells with tunable morphology, properties, and composition (see picture). These inorganic chemical cells (iCHELLs), which show redox activity, chirality, as well as selective permeability towards small molecules, can be nested within one another, potentially allowing stepwise reactions to occur in sequence within the cell.
A Framework for Activity Recognition and Detection of Unusual Activities. (2004)

In this paper we present a simple framework for activity recognition based on a model of multi-layered finite state machines, built on top of a low level image processing module for spatio-temporal detections and limited object identification. The finite state machine network learns, in an unsupervised mode, usual patterns of activities in a scene over long periods of time. Then, in the recognition phase, usual activities are accepted as normal and deviant activity patterns are flagged as abnormal. Results, on real image sequences, demonstrate the robustness of the framework. 1.
Starting Requirements of Pipeline Motors (1979)

The design of an induction motor for pipelines is often controlled by the starting requirements, specifically by the starting current limitations imposed by the electrical utility. Designing the motor to meet across-the-line starting current limits means that full load running performance characteristics are compromised. Alternate starting methods can allow for optimizing the full load performance and result in a reduction of initial and operating costs.
A microprocessor based drug infusion control system employing a model reference adaptive control algorithm to regulate blood pressure in ICU patients (2003)

The authors present an approach for adaptive control of blood pressure using sodium nitroprusside. A modified stochastic model reference adaptive control algorithm with a time-varying reference model is developed and used for this purpose. An automatic adjustment of the reference model is proposed to optimize the performance of the closed-loop system while meeting clinical constraints imposed on the infusion rate and the mean arterial pressure. The algorithm has been implemented in a microprocessor-based system. The system has been verified for proper functionality with the aid of a hardware patient model for a wide range of patient parameters.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Anchored conversations (2000)

This paper describes an application-independent tool called Anchored Conversations that brings together text-based conversations and documents. The design of Anchored Conversations is based on our observations of the use of documents and text chats in collaborative settings. We observed that chat spaces support work conversations, but they do not allow the close integration of conversations with work documents that can be seen when people are working together face-to-face. Anchored Conversations directly addresses this problem by allowing text chats to be anchored into documents. Anchored Conversations also facilitates document sharing; accepting an invitation to an anchored conversation results in the document being automatically uploaded. In addition, Anchored Conversations provides support for review, catch-up and asynchronous communications through a database. In this paper we describe motivating fieldwork, the design of Anchored Conversations, a scenario of use, and some preliminary results from a user study.
Anisotropic thermal expansion coefficients of Y/sub 2/O/sub 3/-stabilized tetragonal zirconia (1986)

The transformability of the grains in tetragonal zirconia polycrystals is determined by thermal stresses (eigenstresses) which develop because of anisotropic expansion behavior of the tetragonal grains on cooling. Anisotropic thermal expansion coefficients based on lattice parameter determinations at room temperature and 600/sup 0/ and 800/sup 0/C are presented for tetragonal zirconia containing 2 and 3 mol% Y/sub 2/O/sub 3/. The sources of errors in these data are discussed.
International trends in the incidence of cervical cancer: I. Adenocarcinoma and adenosquamous cell carcinomas (1998)

Time trends in the incidence of cervical adenocarcinoma and adenosquamous cell carcinomas during the period 1973-1991 were examined using data provided by 60 population-based cancer registries from 32 defined populations in 25 countries. Three components of the incidence trend were studied: age, calendar period of diagnosis and birth cohort. Cumulative incidence rates per 1,000 for 2 groups with age ranges 25-49 and 50-74 years were calculated from the model that best described the incidence data. There was a significant increase in the cumulative incidence of cervical adenocarcinomas in women born in the mid-1930s and in successive cohorts thereafter in some populations in the United States (whites and Hispanic women), Australia, New Zealand (non-Maori), England, Scotland, Denmark, Slovenia, Slovakia and Japan (Osaka) and among Chinese women in Singapore, with a general decline in the incidence in women born in earlier periods. In Sweden and Slovenia there is a suggestion of an increasing trend in both age groups. A decrease in incidence in both age groups was apparent in Finland, France and Italy. There were no changes in incidence in 24 registries covering other European, Asian and black populations in the United States. Part of the increase may be attributable to an increasing prevalence of human papillomavirus infection, and part to improvements in screening.
Structural and Mutational Analyses of the Molecular Interactions between the Catalytic Domain of Factor XIa and the Kunitz Protease Inhibitor Domain of Protease Nexin 2 (2005)

Factor XIa (FXIa) is a serine protease important for initiating the intrinsic pathway of blood coagulation. Protease nexin 2 (PN2) is a Kunitz-type protease inhibitor secreted by activated platelets and a physiologically important inhibitor of FXIa. Inhibition of FXIa by PN2 requires interactions between the two proteins that are confined to the catalytic domain of the enzyme and the Kunitz protease inhibitor (KPI) domain of PN2. Recombinant PN2KPI and a mutant form of the FXI catalytic domain (FXIac) were expressed in yeast, purified to homogeneity, co-crystallized, and the structure of the complex was solved at 2.6 angstroms (Protein Data Bank code 1ZJD). In this complex, PN2KPI has a characteristic, disulfide-stabilized double loop structure that fits into the FXIac active site. To determine the contributions of residues within PN2KPI to its inhibitory activity, selected point mutations in PN2KPI loop 1 11TGPCRAMISR20 and loop 2 34FYGGC38 were tested for their ability to inhibit FXIa. The P1 site mutation R15A completely abolished its ability to inhibit FXIa. IC50 values for the wild type protein and the remaining mutants were as follows: PN2KPI WT, 1.28 nM; P13A, 5.92 nM; M17A, 1.62 nM; S19A, 1.86 nM; R20A, 5.67 nM; F34A, 9.85 nM. The IC50 values for the M17A and S19A mutants were not significantly different from those obtained with wild type PN2KPI. These functional studies and activated partial thromboplastin time analysis validate predictions made from the PN2KPI-FXIac co-crystal structure and implicate PN2KPI residues, in descending order of importance, Arg15, Phe34, Pro13, and Arg20 in FXIa inhibition by PN2KPI.
Immunoregulation of Experimental Allergic Encephalomyelitis: Conditions for Induction of Suppressor Cells and Analysis of Mechanism (1977)

We determined requirements for the induction of immunoregulatory suppressor cells in experimental allergic encephalomyelitis (EAE) in Lewis rats. Pretreatment of rats with myelin basic protein (BP) in incomplete Freund's adjuvant (IFA) stimulates the proliferation of suppressor cells that localize in lymph nodes and spleen (but not thymus) and exert control over the development of clinical EAE. Dosage studies revealed that 3 X 10(7) suppressor cells can adoptively transfer suppression to syngeneic recipients. Transferred unresponsiveness wanes within 3 weeks, indicating that the suppressor cells are short-lived lymphocytes, although actively induced unresponsiveness persists for at least 8 weeks, probably as a result of continual proliferation under the influence of antigen. No evidence was obtained to suggest that antigen carry-over or blocking antibody production accounts for adoptive transfer of unresponsiveness. Suppressor cells apparently act at the inductive phase of the immune response since they had no inhibitory effect on adoptive transfer of disease by effector lymph node cells. Other mechanisms also may play a role in unresponsiveness to EAE, since rats pretreated i.v. with high dosages of soluble BP were temporarily rendered unresponsive, although suppressor cells could not be detected in these animals.
Robustness analysis for a neural network based adaptive control scheme (2005)

A recently developed approach to the control of uncertain nonlinear systems uses a neural network to improve upon dynamic inversion. In the proposed architecture, the neural network adaptively cancels inversion errors through online learning. Asymptotic stability of the closed-loop system is guaranteed based on Lyapunov analysis. In this sense, the control scheme is similar to more traditional adaptive control techniques. This approach does not account for unmodeled dynamics, however, since it assumes precise knowledge of the plant order. In this paper, singular perturbation arguments are employed to show robustness to unmodeled dynamics at the plant input. The theoretical result is illustrated using a simplified nonlinear model of the longitudinal dynamics of an air-to-air missile.