gebhart/patrepeval huggingface dataset:
MicroRNA-200c mitigates invasiveness and restores sensitivity to microtubule-targeting chemotherapeutic agents (2009)

The transcription factor ZEB1 is normally not expressed in epithelial cells. When inappropriately expressed in carcinomas, ZEB1 initiates epithelial to mesenchymal transition due to its ability to repress E-cadherin and other genes involved in polarity. Recently, ZEB1 and ZEB2 have been identified as direct targets of the microRNA-200c family. We find that miR-200c levels are high in well-differentiated endometrial, breast, and ovarian cancer cell lines, but extremely low in poorly differentiated cancer cells. Low or absent miR-200c results in aberrant expression of ZEB1 and consequent repression of E-cadherin. Reinstatement of miR-200c to such cells restores E-cadherin and dramatically reduces migration and invasion. Microarray profiling reveals that in addition to ZEB1 and ZEB2, other mesenchymal genes (such as FN1, NTRK2, and QKI), which are also predicted direct targets of miR-200c, are indeed inhibited by addition of exogenous miR-200c. One such gene, class III β-tubulin (TUBB3), which encodes a tubulin isotype normally found only in neuronal cells, is a direct target of miR-200c. This finding is of particular significance because we show that restoration of miR-200c increases sensitivity to microtubule-targeting agents by 85%. Because expression of TUBB3 is a common mechanism of resistance to microtubule-binding chemotherapeutic agents in many types of solid tumors, the ability of miR-200c to restore chemosensitivity to such agents may be explained by its ability to reduce TUBB3. Because miR-200c is crucial for maintenance of epithelial identity, behavior, and sensitivity to chemotherapy, we propose that it warrants further investigation as a therapeutic strategy for aggressive, drug-resistant cancers.
La familia Pyramidellidae Gray, 1840 (Mollusca, Gastropoda, Heterostropha) en África Occidental. 4. Los géneros Megastomia, Odostomia, Ondina, Noemiamea y Syrnola (1999)

The Atlantic species of the genus <em>Odostomia </em>(s. l.), nowadays divided in several genera, cited or found in the West coast of Africa (from Mediterranean to South Angola) are revised. For each species, the material studied and localities where they were found are indicated, as well as the geographic range of distribution, stablishing the names considered valid and their synonyms. In total, 95 species are studied: 22 of them are considered as belonging to the genus <em>Megastomia, </em>58 to <em>Odostomia</em>, 6 to <em>Ondina</em>, 1 to <em>Noemiamea </em>and 8 to <em>Syrnola</em>. 31 species are described as new for science in the present work, but 3 of them without name due to its scarce material. A key to species on each genus is presented.
A Methodology for Autonomous Robotic Manipulation of Valves Using Visual Sensing∗∗This work was partially supported by the Brazilian Funding Agencies CNPq, CAPES and the Norwegian Research Council. (2015)

This work presents a methodology for autonomous manipulation of valves using a dual-arm robot and the visual sensing provided by cameras mounted on the head and each robot arm. A novel image-based identification and pose estimation method is devised to determine the valve to be manipulated as well as to estimate its position and orientation with respect to the robot base. The valve pose is used in the positioning and alignment of the robot end effector enabling the manipulation task to be carried out autonomously. Experimental results, obtained with a BaxterTM robot performing valve turning tasks, illustrate the feasibility of the proposed methodology. The main objective of this work is to provide capabilities to develop new solutions and innovative technologies to deal with the challenge of manipulating valves autonomously in poorly structured and harsh environments
Chiral Separations: A Review of Current Topics and Trends (2011)

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTChiral Separations: A Review of Current Topics and TrendsTimothy J. Ward* and Karen D. WardView Author Information Millsaps College, 1701 N. State Street, Box 150306, Jackson, Mississippi 39210, United States*Phone: (601) 974-1405. Fax: (601) 974-1401. E-mail: [email protected]Cite this: Anal. Chem. 2012, 84, 2, 626–635Publication Date (Web):November 8, 2011Publication History Published online8 December 2011Published inissue 17 January 2012https://pubs.acs.org/doi/10.1021/ac202892whttps://doi.org/10.1021/ac202892wreview-articleACS PublicationsCopyright © 2011 American Chemical SocietyRequest reuse permissionsArticle Views10864Altmetric-Citations416LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Chromatography,Macrocyclic compounds,Molecular structure,Oligosaccharides,Reaction products Get e-Alerts
A client‐side Web agent for document categorization (1998)

The authors propose a client‐side agent for exploring and categorizing documents on the World Wide Web. As the user browses the Web using a usual Web browser, this agent is designed to aid the user by classifying the documents the user finds most interesting into clusters. The agent carries out the task completely automatically and autonomously, with as little user intervention as the user desires. The principal novel components in this agent that make it possible are a scalable hierarchical clustering algorithm and a taxonomic label generator. In this paper, the overall architecture of this agent is described and the details of the algorithms within its key components are discussed.
Chemical Profile and Biological Potential of Non-Polar Fractions from Centroceras clavulatum (C. Agardh) Montagne (Ceramiales, Rhodophyta) (2011)

The present study reports the Gas Chromatography-Mass Spectrometry (GC-MS) evaluation of the hexanes and dichloromethane fractions from extracts of the red alga Centroceras clavulatum (C. Agardh) Montagne. Twenty three compounds were identified, totaling ca. 42% of both fractions (0.18 g mass extract). The main constituents of the fractions were hexadecanoic acid (17.6%) and pentadecanoic acid (15.9%). Several secondary metabolites with interesting biological activity, such as (-)-loliolide, neophytadiene, phytol were identified. In addition, several classes of secondary metabolites, including phenolic compounds (e.g., phenylacetic acid), terpene derivatives, fatty acids, halogenated compound (e.g., 2-chlorocyclohexenol), lignoids, steroids, esters, amides (e.g., hexadecanamide), ketones, carboxylic acids, aldehydes and alcohols were observed. The occurrence of several of these structural classes is described for the first time in this species. The same fractions analyzed by GC-MS, and a separate set of polar fractions, were evaluated against two life cycle stages (epimastigote and trypomastigote forms) of the protozoan Trypanosoma cruzi and against phytopatogenic fungi Cladosporium cladosporiodes and C. sphaerospermum. The dichloromethane fraction was active against both T. cruzi forms (epimastigote IC(50) = 19.1 μg.mL-1 and trypomastigote IC(50) = 76.2 μg.mL-1). The hexanes and ethyl acetate fractions also displayed activity against both fungi species (200 μg) by TLC-bioautography.
Wavelet families of increasing order in arbitrary dimensions (2000)

We build discrete-time compactly supported biorthogonal wavelets and perfect reconstruction filter banks for any lattice in any dimension with any number of primal and dual vanishing moments. The associated scaling functions are interpolating. Our construction relies on the lifting scheme and inherits all of its advantages: fast transform, in-place calculation, and integer-to-integer transforms. We show that two lifting steps suffice: predict and update. The predict step can be built using multivariate polynomial interpolation, while update is a multiple of the adjoint of predict. While we concentrate on the discrete-time case, some discussion of convergence and stability issues together with examples is given.
Cationic photopolymerization of alkyl glycidyl ethers (2006)

Abstract An investigation of the photoactivated cationic ring‐opening frontal polymerizations of a series of alkyl glycidyl ethers was carried out with the aid of a novel technique, optical pyrometry. With this technique, the effects of various experimental parameters, such as the photoinitiator type and concentration, as well as the effects of the monomer structure on the frontal behavior of these monomers were examined. Upon irradiation with UV light, the photopolymerizations of many alkyl glycidyl ethers displayed a prominent induction period at room temperature as the result of the formation of long‐lived, relatively stable secondary oxonium ions. The input of only a small amount of thermal activation energy was required to induce the further reaction of these species with the consequent autoaccelerated exothermic ring‐opening polymerization. Photoactivated frontal polymerizations were observed for both mono‐ and polyfunctional alkyl glycidyl ether monomers. The ability of monomers to exhibit frontal behavior was found to be related to their ability to stabilize the secondary oxonium ion intermediates through hydrogen‐bonding effects. © 2006 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 44: 3036–3052, 2006
Astroglia‐mediated effects of uric acid to protect spinal cord neurons from glutamate toxicity (2007)

Uric acid (UA) has been demonstrated to reduce damage to neurons elicited by oxidative stress. However, our studies utilizing cultures derived from embryonic rat spinal cord indicate that an astroglia-mediated mechanism is involved in the effects of UA to protect neurons from glutamate toxicity. The damage elicted by glutamate to neurons in a mixed culture of spinal cord cells can be reversed by UA. Furthermore, addition of UA after the termination of glutamate exposure suggests that UA plays an active role in mediating neuroprotection rather than purely binding peroxynitrite, as previously thought. Importantly, in pure neuron cultures from the same tissue, UA does not protect against glutamate toxicity. Addition of astroglia to the pure neuron cultures restores the ability of UA to protect the neurons from glutamate-induced toxicity. Our results also suggest that glia provide EAAT-1 and EAAT-2 glutamate transporters to protect neurons from glutamate, that functional EAATs may be necessary to mediate the effects of UA, and that treatment with UA results in upregulation of EAAT-1 protein. Taken together, our data strongly suggest that astroglia in mixed cultures are essential for mediating the effects of UA, revealing a novel mechanism by which UA, a naturally produced substance in the body, may act to protect neurons from damage during insults such as spinal cord injury.
Micromethod for the assay of renin of seven species. (1979)

Renin was extracted and purified from human, dog, hog, rat, beef, rabbit and sheep kidneys. The renin "concentration" of these preparations was determined and expressed in international (Goldblatt) units by measuring the pressor effect produced by intravascular injection into normal dogs of a permanent colony. The renin "activity" was determined by bioassay, in the rat, of the angiotensin produced by incubation in vitro with renin substrate prepared from the serum of nephrectomized dogs. The rate of angiotensin formation was proportional to the concentration of renin, independent of the substrate concentration, and rather similar for renin of all seven species (mean rate = 55 x 10(4) ng angiotensin/unit renin/16 hrs). Due to this uniformity, either of the two international reference preparations of renin (human or hog) from the World Health Organization can serve as an internal standard in the assay of reninof each of the seven species, to express their concentration in terms of the international unit. Renin substrate from hog plasma was suitable for the assay of human, dog and hog renin (mean rate = 55 x 10(4)). However, it reacted much more slowly with the renin of rat, beef, rabbit and sheep (mean rate = 9 x 10(4)) and was, therefore, less suitable for their assay.
Seismic denoising with nonuniformly sampled curvelets (2006)

The authors present an extension of the fast discrete curvelet transform (FDCT) to nonuniformly sampled data. This extension not only restores curvelet compression rates for nonuniformly sampled data but also removes noise and maps the data to a regular grid
JUAN DE VINGLES (JEAN DE VINGLE) (1937)

Journal Article JUAN DE VINGLES (JEAN DE VINGLE): A SIXTEENTH-CENTURY BOOK ILLUSTRATOR Get access HENRY THOMAS HENRY THOMAS Search for other works by this author on: Oxford Academic Google Scholar The Library, Volume s4-XVIII, Issue 2, September 1937, Pages 121–176, https://doi.org/10.1093/library/s4-XVIII.2.121 Published: 01 September 1937
Chemically induced paramutation at the R locus in maize. (1967)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
Putting thought into networks (1994)

Intelligent networks (INs) are changing the culture and structure of the telecoms industry, and will change the way that customers think about telephone services. Yet they are doing all this largely unnoticed. The changes are gradual, the name 'intelligent network' means different things to different people, and the only glamorous technologies involved are something of a distraction. INs are a natural technological progression. They are an example of how innovation in services can result from the novel application of conventional technology. INs exploit the improvement in performance and reliability of data processing systems, which means that ordinary computer equipment can be used to control telephone calls in real time. Here, the author explains how intelligent networks are changing the way telecoms services work.
Multiple predictors of coronary restenosis after drug-eluting stent implantation in patients with diabetes (2006)

Even with the introduction of DES, diabetes remains a significant predictor of coronary restenosis, especially in cases of a small baseline vessel size, small vessel size after percutaneous coronary intervention, longer stent length, use of the paclitaxel-eluting stent, current smoking and high C reactive protein concentration.
Fly Ash Size Distributions: Use of coulter multisizer and fitting to truncated lognormal distributions (1993)

Abstract Accurate information on the size distribution of fly ash is needed to determine its role in the radiation transfer process in pulverized coal combustors. The Coulter Multisizer was used to determine the size distribution in the particle diameter range 1–200 μm. To size over such large diameter ranges, data must be obtained using several orifices, and then combined. In order to use the smaller orifices, the larger particles have to be removed from the sample. A wet‐sieving apparatus, designed for accurate separation of the particles by size, is described. A scheme for combining data obtained using orifices of different diameters is presented. It appears from this study that the lower limit of size measurement using an orifice is set by sensitivity, rather than by signal/noise. A lognormal distribution function, truncated outside the measurement limits, fits the size distribution data well. This function allows detailed size information to be stored compactly using four parameters. Size parameters for six fly ashes representative of U. S. coals are presented.
Protein-Spleißen: Mechanismus und Anwendungen (2000)

Protein-Spleißen, das Äquivalent des RNA-Spleißens auf Proteinebene, ist ein neu entdeckter posttranslationaler Prozess, der über ein verzweigtes Protein-Intermediat zur Bildung zweier verschiedener Polypeptide führt, die sich vom selben Gen ableiten. Die experimentellen Befunde zur Aufklärung des vollständigen Mechanismus des Protein-Spleißens sowie zahlreiche Anwendungen für das Protein-Engineering unter Verwendung von modifizierten Inteinen werden beschrieben, darunter die Einführung von α-Thioesterbindungen in Proteine, wodurch die Beschränkungen der Festphasensynthese von Peptiden umgangen werden.
Nanotechnology and Tissue Engineering: The Scaffold (2008)

SECTION I: Importance of Scaffolds in Tissue Engineering Tissue Engineering: The Therapeutic Strategy of the Twenty-First Century, F. Yang, W.L. Neeley, M.J. Moore, J.M. Karp, A. Shukla, and R. Langer Top-Down Analysis of a Dynamic Environment: Extracellular Matrix Structure and Function, M. Veiseh, E.A. Turley, and M.J. Bissell Functions and Requirements of Synthetic Scaffolds in Tissue Engineering, T. Shyam Karande and C. Mauli Agrawal Microfabrication Techniques in Scaffold Development, C.J. Bettinger, J.T. Borenstein, and R. Langer SECTION II: Effect of Nanostructures on Cellular Responses and Tissue Regeneration Cell Response to Nanoscale Features and Its Implications in Tissue Regeneration: An Orthopedic Perspective, B. Ercan and T. Webster Surface Modification of Biomaterials at the Nanoscale: Biomimetic Scaffolds for Tissue Engineering Applications, D.A. Lee and C.T. Laurencin SECTION III: Promising Nanofabrication Techniques to Develop Scaffolds for Tissue Engineering Electrospun Polymeric Nanofiber Scaffolds for Tissue Regeneration, S. Prasad Nukavarapu, S.G. Kumbar, J.G. Merrell, and C.T. Laurencin Structure and Mechanical Properties of Electrospun Nanofibers and Nanocomposites, E. Phay Shing Tan and C. Teck Lim Electrospinning Techniques to Control Deposition and Structural Alignment of Nanofibrous Scaffolds for Cellular Orientation and Cytoskeletal Reorganization, J.K. Wise, M. Cho, E. Zussman, C.M. Megaridis, and A.L. Yarin Nanolithographic Techniques in Tissue Engineering, B. Moody and G.S. McCarty Designer Self-Assembling Peptide Scaffolds for Tissue Engineering and Regenerative Medicine, A. Horii, X. Wang, and S. Zhang SECTION IV: Applications of Nanostructured Scaffolds in Biology and Medicine Nanotechnologies in Neural Tissue Engineering, V. Mukhatyar, J. Yeh, and R. Bellamkonda Nanotechnologies for Cardiovascular Tissue Engineering, K.A. Wieghaus and E.A. Botchwey Nanostructures for Musculoskeletal Tissue Engineering, S. Liao, C.K. Chan, and S. Ramakrishna Index
Therapeutic peptides: Historical perspectives, current development trends, and future directions (2017)

Peptide therapeutics have played a notable role in medical practice since the advent of insulin therapy in the 1920s. Over 60 peptide drugs are approved in the United States and other major markets, and peptides continue to enter clinical development at a steady pace. Peptide drug discovery has diversified beyond its traditional focus on endogenous human peptides to include a broader range of structures identified from other natural sources or through medicinal chemistry efforts. We maintain a comprehensive dataset on peptides that have entered human clinical studies that includes over 150 peptides in active development today. Here we provide an overview of the peptide therapeutic landscape, including historical perspectives, molecular characteristics, regulatory benchmarks, and a therapeutic area breakdown.
Biosynthetic Skin Substitute versus Frozen Human Cadaver Allograft for Temporary Coverage of Excised Burn Wounds (1987)

During the past 2 years a multicenter study was performed comparing Biobrane (Woodroof) and frozen cadaver allograft as temporary dressings on freshly excised full-thickness burns before the application of autograft. Each biologic dressing was evaluated with respect to the other on the same patient. Seventy-one patients were evaluated. The mean burn size was 35 +/- 20% with a mean full-thickness burn of 28 +/- 20%. Mean patient age was 34 +/- 21 years. Overall survival was 82%. The mean time of wound coverage was 10.2 +/- 6.7 days. There was no significant difference in the number of dressing changes, area changed, purulence, autograft take, and final results between allograft- and Biobrane-covered sites. There were no complications following use of either Biobrane or allograft. We conclude that Biobrane is as effective as frozen human cadaver allograft for the temporary coverage of freshly excised full-thickness burn wounds before autografting.
Magnetic Movement of a Brain Thermoceptor (1989)

Hyperthermia has significant potential as an adjuvant form of brain tumor therapy. Current intracranial hyperthermia methods, however, are limited in their ability to control spatiotemporal thermal distribution. A stereotaxic magnetic movement system that may be capable of heating discrete regions of brain to a preselected temperature is described. With this system, a ferromagnetic object (referred to as a thermoceptor) is directed through the brain by an external drive magnet. Real time thermoceptor position is monitored with biplanar fluoroscopy and superimposed on a preoperative magnetic resonance imaging scan using a computer. Once in position, the thermoceptor can be inductively heated by externally generated radiofrequency signals. Experiments on the magnetic drive and imaging aspects of this system have been conducted in vitro and in vivo. Mechanical studies of cadaver dog brains revealed that a mean force of 0.07 +/- 0.03 N was required to move a 3-mm diameter sphere through brain at a speed of less than 1 cm/15 s. A cranial phantom with mechanical properties similar to brain was constructed of gelatin and Plexiglas. With the use of a "neck loop" design drive magnet with a maximum magnetic field strength of 0.10 T, a 3 x 3 mm cylindrical neodymium iron boron thermoceptor was smoothly directed through the phantom in two dimensions. Additional experiments were conducted with a larger drive magnet in five anesthetized dogs. Neodymium iron boron and samarium cobalt thermoceptors of various shapes and sizes were placed into the cerebral cortex through a burr hole, then directed with the drive magnet. Fluoroscopy was used to follow the thermoceptor movements.(ABSTRACT TRUNCATED AT 250 WORDS)
Timing failure detection and real-time group communication in quasi-synchronous systems (2002)

This paper addresses the problem of having real-time group communication in systems that are not completely synchronous (quasi-synchronous). This situation can happen when load is not completely controlled thus not ruling out overload scenarios This is usually related to dynamic characteristics of the application and/or environment. Usually in such systems, temporal guarantees can only be made to the highest priority messages. In such scenario we propose to use the highest priority messages (ora dedicated synchronous channel if available) to implement a timing failure detection service. By using this service together with the communication protocols, we are able to provide safety in a timely fashion, which is of utmost importance for distributed fault-tolerant real-time applications.