gebhart/patrepeval huggingface dataset:
Modeling, simulation and optimization of maintenance cost aspects on multi-unit systems by stochastic Petri nets with predicates (2018)

The paper addresses repairable multi-unit systems with a series–parallel configuration for which maintenance strategies are modeled by generalized stochastic Petri nets (GSPN) with predicates coupled with Monte Carlo simulation. Four maintenance strategies consisting of basic periodic preventive and corrective maintenance, and both combined with opportunistic maintenance (OM) strategies, are considered. Failure and repair distributions of the system components are independent, and repairs are considered to be perfect. Times to failure of degraded components follow a Weibull distribution with increasing failure rate over time. The maintenance strategies are optimized so as to minimize the total maintenance costs of the system while maximizing availability. A comparison is drawn between OM and non-OM. The aim is to show that GSPN with predicates, in combination with Monte Carlo simulation, is a powerful, flexible, efficient, and intuitive approach for modeling and optimizing practical maintenance strategies on multi-unit complex systems, modeling the dynamic behavior resulting from the interaction between system components and economic dependencies. The merits and advantages of GSPN coupled with Monte Carlo simulation are enhanced relative to other, analytical, approaches.
Fungemia with Saccharomycetaceae: Report of four Cases and Review of the Literature (1990)

Invasive fungal disease with Saccharomycetaceae is very rarely reported and these fungi are usually considered nonpathogenic. We report here 4 cases of positive blood cultures with fungal species belonging to this family. Severe neutropenia, permanent central venous catheter, ongoing antibacterial chemotherapy, and major abdominal surgery were identified as risk factors for fungemia in patients. In the immunocompromised host isolation of such species from sterile fluids cannot be ignored but should be considered an opportunistic infection and treated as such.
Epaxal<sup>®</sup>: a virosomal vaccine to prevent hepatitis A infection (2008)

Over the last few decades, different types of inactivated hepatitis A virus (HAV) vaccines have been developed: several aluminum-adjuvanted vaccines and an aluminum-free, virosome-formulated vaccine. Both types of vaccines are whole-virus preparations that are produced by growth of HAV strains in human diploid cell cultures and are subsequently inactivated with formaldehyde. This review summarizes all published papers on a virosome-formulated vaccine, Epaxal®, based on formalin inactivated HAV (strain RG-SB) adsorbed to the surface of special liposomes (virosomes), that replace aluminum hydroxide as the adjuvant principle. A single injection of virosomal HAV vaccine is well tolerated and highly immunogenic, with 88–97% of seroprotection 2 weeks after a first dose. HAV virosomal vaccine can be administered concomitantly with other vaccines, without inducing antigenic competition. Direct comparison with aluminum-adsorbed vaccine has shown that the immunogenicity was similar, but fewer local reactions were reported with Epaxal. Recent studies in children have demonstrated that Epaxal Junior is also an excellent HAV vaccine for mass vaccination programs.
Preparation of Photoconductive Films of Cadmium Sulfide* (1955)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text R. C. Nelson, "Preparation of Photoconductive Films of Cadmium Sulfide*," J. Opt. Soc. Am. 45, 774_1-775 (1955) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
LPCVD of Borophosphosilicate Glass from Organic Reactants (1987)

Borophosphosilicate glass films have been deposited in an LPCVD reactor using organic compounds as reactants. The silicon containing reactant is tetraethoxysilane (TEOS), the boron reactant is trimethylborate (TMB) and the phosphorus reactant is trimethylphosphite (TMP). A process is described that produces uniform films of boron concentration between 1 and 4 weight percent (w/o) and phosphorus concentration between 2 and 5 w/o. The films have nearly conformal step coverage and flow at temperatures as low as 850°C. The films show minor thickness changes after annealing in air or argon and are not detectably degraded by moisture. The properties of the material and the dependence of film composition on reactant flow rates and temperature are presented. The dependence of the index of refraction on phosphorus concentration and the dependence of viscous flow on the boron and phosphorus concentration is detailed. A discussion of the conditions for formation of two observed microstructural defects is presented.
Minnesota and the Manifest Destiny of the Canadian Northwest: A Study in Canadian-American Relations. By Alvin C. Gluek Jr. Toronto: University of Toronto Press, 1965. Pp. xi, 311. $7.50. (1966)

Minnesota and the Manifest Destiny of the Canadian Northwest: A Study in Canadian-American Relations. By Alvin C. Gluek Jr. Toronto: University of Toronto Press, 1965. Pp. xi, 311. $7.50. - Volume 26 Issue 2
Binding of Cu(II) or Zn(II) in a de novo designed triple‐stranded <i>α</i>‐helical coiled‐coil toward a prototype for a metalloenzyme (2004)

We previously reported the IZ-3adH peptide, which formed a triple-stranded coiled-coil after binding Ni(II), Cu(II), or Zn(II). In this paper, we report the peptide, IZ-3aH, having a new metal binding specificity. The IZ-3aH peptide was found to bind Cu(II) and Zn(II) and form a triple-stranded coiled-coil. However, it did not bind Ni(II). Metal ion titrations monitored by circular dichroism revealed that the dissociation constants, K(d) were 9 microm for Zn(II) and 10 microm for Cu(II). The bound Cu(II) ion has a planar tetragonal geometry, where the coordination positions are three nitrogens of the His residues and one H(2)O.
Plasminogen activator-specific inhibitors in mouse macrophages: in vivo and in vitro modulation of their synthesis and secretion. (1987)

Mouse resident peritoneal macrophages synthesize two plasminogen activator-specific inhibitors (PAI) that are functionally and antigenically related, but differ in their apparent Mr and oligosaccharide content. Most of the Mr 40,000 inhibitor can be recovered from the cell lysate, whereas the Mr 55,000 glycosylated PAI is preferentially secreted. The murine macrophage PAI are functionally similar and immunologically related to PAI synthesized and secreted by human monocytes-macrophages, and to a PAI from human placenta (PAI-2). PAI production by murine mononuclear phagocytes can be modulated both in vivo and in vitro. Bone marrow-derived macrophages do not produce detectable PAI, whereas inflammatory macrophages obtained from thioglycollate-induced peritoneal exudates produce only low levels of PAI. In cultures of resident peritoneal macrophages, phorbol myristate acetate and cholera toxin increase the synthesis of the Mr 55,000 secreted PAI, whereas dexamethasone decreases the synthesis of both PAI; the production of PAI is also enhanced in the presence of macrophage colony-stimulating factor (CSF-1). The overall proteolytic activity of mononuclear phagocytes thus depends in part on the controlled synthesis and secretion of PAI. The balance between the production of plasminogen activators and of their inhibitors could be critical in determining the level of plasminogen-dependent extracellular proteolysis associated with different phases of the inflammatory response.
Vaccines and vaccination against fowl typhoid and pullorum disease: An overview and approaches in developing countries (2018)

In poultry, host-specific Salmonella infections cause fowl typhoid and pullorum disease, which are severe systemic diseases of chickens that result in severe problems and high mortality and produce economic losses in developing countries. Fowl typhoid and pullorum disease have reemerged in recent years in developing countries, and birds of any age can be infected. Developing countries have established sanitary measures and official programs to prevent and control both diseases; however, there are cyclic or seasonal outbreaks related to disease management. An overview of the current situation and future perspectives regarding live attenuated vaccines against fowl typhoid and pullorum disease are discussed.
Small-Scale Acoustic Streaming in Liquids (1956)

By using special acoustical and optical arrangements, vortex motions are discovered in the vicinity of small vibrating sources in liquids. Of particular importance is the vigorous eddying that typically takes place near a vibrating gas bubble when it rests on a boundary. This bubble-associated streaming has been observed under a variety of circumstances, and apparently occurs quite generally. Especially violent and chaotic motions appear near bubbles of resonant size. The attendant highly localized convection and viscous stresses are probably very important as intermediate physical mechanisms for sonic irradiation effects.
Stable pole-zero modeling of long FIR filters with application to the MMSE-DFE (1997)

The problem of approximating a long FIR filter by a reduced-parameter stable pole-zero filter is addressed. We derive a computationally efficient order-recursive algorithm that achieves this task with high accuracy. Our main emphasis is on applying this algorithm to reduce the implementation complexity of the decision feedback equalizer's long FIR feedforward and feedback filters encountered in high-speed data transmission on digital subscriber loops.
Contrast Restoration by Adaptive Countershading (2007)

Abstract The ABSTRACT is to be in fully‐justified italicized text, between two horizontal lines, in one‐column format, below the author and affiliation information. Use the word “Abstract” as the title, in 9‐point Times, boldface type, left‐aligned to the text, initially capitalized. The abstract is to be in 9‐point, single‐spaced type. The abstract may be up to 3 inches (7.62 cm) long. Leave one blank line after the abstract, then add the subject categories according to the ACM Classification Index (see http://www.acm.org/class/1998/ ).
Expression and mapping of lubricin in canine flexor tendon (2006)

Matrix composition and the biomechanical environment are intimately interdependent in most connective tissues. Lubricin has many distinct biological functions, including lubrication, antiadhesion, and cytoprotection in cartilage, tendons, and other tissues. This study investigated the distribution of lubricin in the canine flexor digitorum profundus (FDP) tendon by immunohistochemistry. Lubricin was found both on the tendon surface and at the interface of collagen fiber bundles within the tendon, where the cells are subjected to shear force in addition to tension and compression. The expression of lubricin in regions of the canine flexor tendon that differ in mechanical or nutritional environment was also investigated using RT-PCR. Six N-terminal splicing variants were identified from six distinct anatomical regions of flexor tendon. The variants with larger sizes were noted in regions subjected to significant shear and compressive forces. Lubricin is ubiquitous in the FDP tendon, with variations in distribution and splicing that appear to correspond to discrete anatomic locations that differ by mechanical or nutritional environment.
Effect of finite sample size on feature selection and classification: A simulation study (2010)

None of the investigated feature selection-classifier combinations provided consistently superior performance under the studied conditions for different sample sizes and feature space distributions. In general, the SFFS method was comparable to the SFS method while PCA may have an advantage for Gaussian feature spaces with unequal covariance matrices. The performance of the SVM with radial kernel was better than, or comparable to, that of the SVM with polynomial kernel under most conditions studied.
Systemically Administered Sindbis Virus in Combination with Immune Checkpoint Blockade Induces Curative Anti-tumor Immunity (2018)

Oncolytic viruses represent a promising form of cancer immunotherapy. We investigated the potential of Sindbis virus (SV) for the treatment of solid tumors expressing the human cancer testis antigen NYESO-1. NYESO-1 is an immunogenic antigen frequently expressed in numerous cancers, such as ovarian cancer. We show that SV expressing the tumor-associated antigen NYESO-1 (SV-NYESO1) acts as an immunostimulatory agent, inducing systemic and rapid lymphocyte activation, leading to a pro-inflammatory environment. SV-NYESO1 treatment combined with anti-programmed death 1 (anti-PD-1) markedly augmented the anti-tumor immunity in mice over the course of treatment, resulting in an avid systemic and intratumoral immune response. This response involved reduced presence of granulocytic myeloid-derived suppressor cells in tumors and an increase in the activation of splenic and tumor-infiltrating T cells. Combined therapy also induced enhanced cytotoxic activity of T cells against NYESO-1-expressing tumors. These results were in line with an observed inverse correlation between T cell activation and tumor growth. Finally, we show that combined therapy resulted in complete clearance of NYESO-1-expressing tumors <i>in vivo</i> and led to long-term protection against recurrences. These findings provide a rationale for clinical studies of SV-NYESO1 combined with immune checkpoint blockade anti-PD-1 to be used in the treatment of NYESO-1-expressing tumors.
Correlation of Early Metastatic Response by<sup>123</sup>I-Metaiodobenzylguanidine Scintigraphy With Overall Response and Event-Free Survival in Stage IV Neuroblastoma (2003)

Semiquantitative MIBG score early in therapy provides valuable prognostic information for overall response and EFS, which may be useful in tailoring treatment.
Optical Property Analyses of Plant Cells for Adaptive Optics Microscopy (2014)

In astronomy, adaptive optics (AO) can be used to cancel aberrations caused by atmospheric turbulence and to perform diffraction-limited observation of astronomical objects from the ground. AO can also be applied to microscopy, to cancel aberrations caused by cellular structures and to perform high-resolution live imaging. As a step toward the application of AO to microscopy, here we analyzed the optical properties of plant cells. We used leaves of the moss Physcomitrella patens, which have a single layer of cells and are thus suitable for optical analysis. Observation of the cells with bright field and phase contrast microscopy, and image degradation analysis using fluorescent beads demonstrated that chloroplasts provide the main source of optical degradations. Unexpectedly, the cell wall, which was thought to be a major obstacle, has only a minor effect. Such information provides the basis for the application of AO to microscopy for the observation of plant cells.
Phosphoramidate ProTides of the Anticancer Agent FUDR Successfully Deliver the Preformed Bioactive Monophosphate in Cells and Confer Advantage over the Parent Nucleoside (2011)

The fluorinated pyrimidine family of nucleosides continues to represent major current chemotherapeutic agents for treating solid tumors. We herein report their phosphate prodrugs, ProTides, as promising new derivatives, which partially bypass the dependence of the current drugs on active transport and nucleoside kinase-mediated activation. They are also resistant to metabolic deactivation by phosphorolytic enzymes. We report 39 ProTides of the fluorinated pyrimidine FUDR with variation in the aryl, ester, and amino acid regions. Notably, only certain ProTide motifs are successful in delivering the nucleoside monophosphate into intact cells. We also find that the ProTides retain activity in mycoplasma infected cells, unlike FUDR. Data suggest these compounds to be worthy of further progression.
An analysis of anti poaching techniques in Africa: A case of rhino poaching (2014)

In the last decade the African continent has been facing a number of incidences on Rhino Poaching and we may be heading to Rhino extinction. A number of strategies have been tried and tested to protect the rhinos in Africa. Based on previous strategies to protect rhinos very little has been achieved in combating rhino poaching. Using extensive literature review this study investigates whether the current conservation methods are still useful in addressing poaching. Literature reveals that most methods have failed to protect rhinos. Therefore, forensic tests, shoot to kill policy and new strategies maybe the only way to avoid rhino extinction.
Electron microscopic and biochemical studies of proteoglycan polydispersity in chick limb bud chondrocyte cultures (1978)

Proteoglycan aggregates from bovine nasal cartilage, from Day 8 and Day 16 chondrocyte cultures derived from chick limb bud mesenchymal cells, and from em- bryonic chick epiphyseal cartilage were visualized as monolayers with electron microscopy. The lengths of the monomers in the aggregates and the average spac- ing of monomers on the central filament of hyaluronic acid were determined. The Gaussian distribution of core lengths for the bovine cartilage sample (343 + 95 nm) was significantly different from the distributions observed for the chick samples. With the exception of the sample derived from Day 16 cultures, all the chick samples gave statistically identical Gaussian distribu- tions (-310 f 60 nm). The Day 16 monomer core length distribution was somewhat skewed toward shorter lengths (297 + 58 nm). The average spacing of mono- mers on hyaluronic acid was larger for a reconstituted aggregate sample from Day 8 culture than for a prep- aration isolated from a similar culture by a procedure which did not involve dissociation of the aggregate structure. In all samples, the number of monomers per aggregate was linearly correlated with the length of hyaluronic acid in the central filament. Chondrocyte cultures were double-labeled with [3H]serine and [14C]serine on Day 8, or on Day 16, or both. Sepharose 2B analyses of the monomer fractions indicated that monomers synthesized on Day 16 had significantly smaller average sizes than those synthe- sized on Day 8. Further, although only 50% of the monomers synthesized on Day 8 remained in the tissue matrix on Day 16, the remaining molecules exhibited an identical size distribution to that of proteoglycans synthesized by Day 8 cultures and isolated directly. Differences in the average sizes of the chondroitin sul- fate chains in the monomer samples account in large part for the smaller sizes of the Day 16 macromolecules. Cartilage proteoglycan monomers consist of a protein core with covalently bound polysaccharide chains of chondroitin sulfate and keratan sulfate. The protein core of these macro- molecules can be divided into three regions; a chondroitin sulfate-enriched region, an intermediate keratan sulfate-en- riched region, and a hyaluronic acid binding region which is located at one end of the molecule (l-4). This noncovalent and highly specific interaction between the protein core of the * This work was supported in part (at Case Western Reserve University) by an Institutional Grant from the American Cancer Society, National Institutes of Health Grants HD-07209, 5T3-6M- 07225,HD-00020, HD-35609, AM-17110, and grants from the National Foundation (March of Dimes). The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked
PHENOPSIS, an automated platform for reproducible phenotyping of plant responses to soil water deficit in <i>Arabidopsis thaliana</i> permitted the identification of an accession with low sensitivity to soil water deficit (2005)

• The high-throughput phenotypic analysis of Arabidopsis thaliana collections requires methodological progress and automation. Methods to impose stable and reproducible soil water deficits are presented and were used to analyse plant responses to water stress. • Several potential complications and methodological difficulties were identified, including the spatial and temporal variability of micrometeorological conditions within a growth chamber, the difference in soil water depletion rates between accessions and the differences in developmental stage of accessions the same time after sowing. Solutions were found. • Nine accessions were grown in four experiments in a rigorously controlled growth-chamber equipped with an automated system to control soil water content and take pictures of individual plants. One accession, An1, was unaffected by water deficit in terms of leaf number, leaf area, root growth and transpiration rate per unit leaf area. • Methods developed here will help identify quantitative trait loci and genes involved in plant tolerance to water deficit.
Junín Virus Pathogenesis and Virus Replication (2012)

Junín virus, the etiological agent of Argentine hemorrhagic fever, causes significant morbidity and mortality. The virus is spread through the aerosolization of host rodent excreta and endemic to the humid pampas of Argentina. Recently, significant progress has been achieved with the development of new technologies (e.g. reverse genetics) that have expanded knowledge about the pathogenesis and viral replication of Junín virus. We will review the pathogenesis of Junín virus in various animal models and the role of innate and adaptive immunity during infection. We will highlight current research regarding the role of molecular biology of Junín virus in elucidating virus attenuation. We will also summarize current knowledge on Junín virus pathogenesis focusing on the recent development of vaccines and potential therapeutics.
Challenges to manufacturing submicron, ultra-large scale integrated circuits (1990)

It is argued that the cost of manufacturing submicron, ultra-large-scale integration (ULSI) integrated circuits (ICs) (which is scaling upward at least in inverse proportion to the downward scaling of device feature sizes) is driven by a parameter budget crisis associated with the technological and complexity limits of IC design and fabrication. This budget crisis is defined for technologies associated with patterning, mechanical control, thermal treatments, particulates and contamination, defects, electrical parameters, and manufacturing, R&D priorities for silicon ULSI are identified and quantified, and the potential impact of some recent research results is discussed. It is pointed out that the R&D agenda to deal with the ULSI manufacturing budget crisis is enormous, and the semiconductor industry cannot perform all of it. Since the time for transferring new developments into production tools and technologies is five to seven years, it is concluded that critical funding decisions need to be made now for ULSI manufacturing science breakthroughs by the turn of the century.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>