gebhart/patrepeval huggingface dataset:
Progress in diagnosis of opportunistic infections in HIV/AIDS. (2005)

The impact of HIV/AIDS is different in developed and developing countries including India. Limited access to health care facilities, lack of infrastructure for diagnostic set up and cost of anti retroviral therapy are some of the reasons. Early accurate diagnosis of opportunistic infections (OIs), the common presenting symptom of the patients, is the key for success of effective management. This review attempts an overview of few of the important OIs with which majority of Indian patients present in the clinics. Emphasis has been on conventional method of diagnostic approach, which is possible in most of the diagnostic laboratory set up in India. Awareness of the disease and maintenance of high index of clinical suspicion are required. An integrated approach to patient management with active interaction between clinicians and microbiologists would be highly beneficial. Introduction of routine in vitro antimicrobial testing system especially for Candida sp, Cryptococcus sp and Mycobacterium sp, is also important, in order to obtain a baseline data on the susceptibility pattern, which not only have therapeutic relevance, but also can predict in advance, any shift in these patterns in the Indian population. Administrative support for the skill development of personnel, facility for data preservation and telemedicine can extend the diagnostic expertise to the remote areas, without affecting the patients mobility.
Electrophoretic shift mutants in Chinese hamster ovary cells: evidence for genetic diploidy. (1978)

Electrophoretic shift mutants induced in Chinese hamster ovary (CHO) cells indicate that these cells not extensively functionally hemizygotic. Therefore, effective haploidy is unsatisfactory as a general theory to explain the frequency of recessive mutants in this cell line. CHO cells were screened for electrophoretic shift variants of enzymes coded by approximately 40 genetic loci. Clones isolated after exposure to ultraviolet radiation were examined by starch gel and Cellogel electrophoresis. Shift variants were recovered for enzymes representing 11 different loci. Variant clones were subcloned to demonstrate the heritability of the variations Mutants at nine loci produced multiple-banded patterns consistent with the patterns expected of genes at loci represented twice (diploid). Chromosome localization of these diploid loci in other mammalian species where they have been mapped, suggests that they represent a random sample of CHO genes. Chromosome analysis of mutant subclones indicated that the variation did not take place in tetraploid cells. The data indicate that the quasi-diploid CHO cells appear only as functionally hemizygous as would be expected of a slightly hypodiploid cell line derived from an organism in which the haploid number is 11.
Preparation and characterization core‐shell particles and application for E‐Ink (2007)

Abstract the core‐shell particles were prepared by dispersion copolymerization. The core‐shell particles were characterized with Fourier‐transform infrared spectroscopy, Transmission electron microscope and scanning electron microscope. The dispersion stability and electrophoretic performance of core‐shell particles were studied in the mixed medium of tetrachloroethylene and cyclohexance. Microcapsules containing the core‐shell particles were prepared by coacervation. Results showed that the core‐shell particles had good dispersion stability and it had no electric response, which could be used as grounding particles for E‐Ink. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci 104: 1195–1199, 2007
Structural and Functional Analysis of Anti-Influenza Activity of 4-, 7-, 8- and 9-Deoxygenated 2,3-Difluoro-<i>N</i>-acetylneuraminic Acid Derivatives (2018)

Competitive inhibitors of the influenza neuraminidase (NA) were discovered almost 20 years ago, with zanamivir and oseltamivir licensed globally. These compounds are based on a transition state analogue of the sialic acid substrate. We recently showed that 5- N-(acetylamino)-2,3,5-trideoxy-2,3-difluoro-d-erythro-β-l-manno-2-nonulopyranosonic acid (DFSA) and its derivatives are also potent inhibitors of the influenza NA. They are mechanism based inhibitors, forming a covalent bond between the C2 of the sugar ring and Y406 in the NA active site, thus inactivating the enzyme. We have now synthesized a series of deoxygenated DFSA derivatives in order to understand the contribution of each hydroxyl in DFSA to binding and inhibition of the influenza NA. We have investigated their relative efficacy in enzyme assays in vitro, in cell culture, and by X-ray crystallography. We found loss of the 8- and 9-OH had the biggest impact on the affinity of binding and antiviral potency.
Appendix to Information Needs in Bug Reports: Improving Cooperation Between Developers and Users (2009)

This technical report contains all data that is needed to replicate the paper “Information Needs in Bug Reports: Improving Cooperation Between Developers and Users” to be published at CSCW 2010 in Savannah, Georgia, USA. The accompanying zip file contains bug reports, cards with categorization, and R scripts that were used in the study.
The Telltale Structures of Epoxide Hydrolases (2003)

Traditionally, epoxide hydrolases (EH) have been regarded as xenobiotic-metabolizing enzymes implicated in the detoxification of foreign compounds. They are known to play a key role in the control of potentially genotoxic epoxides that arise during metabolism of many lipophilic compounds. Although this is apparently the main function for the mammalian microsomal epoxide hydrolase (mEH), evidence is now accumulating that the mammalian soluble epoxide hydrolase (sEH), despite its proven role in xenobiotic metabolism, also has a central role in the formation and breakdown of physiological signaling molecules. In addition, a certain class of microbial epoxide hydrolases has recently been identified that is an integral part of a catabolic pathway, allowing the use of specific terpens as sole carbon sources. The recently available x-ray structures of a number of EHs mirror their respective functions: the microbial terpen EH differs in its fold from the canonical alpha/beta hydrolase fold of the xenobiotic-metabolizing mammalian EHs. It appears that the latter fold is the perfect solution for the efficient detoxification of a large variety of structurally different epoxides by a single enzyme, whereas the smaller microbial EH, which has a particularly high turnover number with its prefered substrate, seems to be the better solution for the hydrolysis of one specific substrate. The structure of the sEH also includes an additional catalytic domain that has recently been shown to possess phosphatase activity. Although the physiological substrate for this second active site has not been identified so far, the majority of known phosphatases are involved in signaling processes, suggesting that the sEH phosphatase domain also has a role in the regulation of physiological functions.
Development of an Autonomous Distributed Control System for Optical Packet and Circuit Integrated Networks (2011)

In this paper, we describe an autonomous distributed control system that we have been developing for an optical packet and circuit integrated network, and we experimentally evaluate its performance. Colored (i.e., multi-wavelength) optical packet-switched links transfer both control signals for circuit switching (e.g., signaling and routing) and best-effort packet data. We successfully transmitted high-definition uncompressed real-time video signals on two lightpaths established by our control system without degradation of video quality, simultaneously with other optical packet data transferred on the same optical fibers. Our developed control system not only achieved autonomous distributed signaling and routing but also has a function that can adjust wavelength resources for optical packet and circuit switching autonomously in each link at each node. Controllers achieved lightpath establishment within approximately 360 ms and dynamic resource adjustment within approximately 454 ms, in the best possible case in our experimental setup.
Problem Statement for the Datagram Congestion Control Protocol (DCCP) (2006)

This document describes for the historical record the motivation
behind the Datagram Congestion Control Protocol (DCCP), an unreliable
transport protocol incorporating end-to-end congestion control. DCCP
implements a congestion-controlled, unreliable flow of datagrams for
use by applications such as streaming media or on-line games. This
memo provides information for the Internet community.
University of Illinois System in HOO Text Correction Shared Task (2011)

In this paper, we describe the University of Illinois system that participated in Helping Our Own (HOO), a shared task in text correction. We target several common errors, such as articles, prepositions, word choice, and punctuation errors, and we describe the approaches taken to address each error type. Our system is based on a combination of classifiers, combined with adaptation techniques for article and preposition detection. We ranked first in all three evaluation metrics (Detection, Recognition and Correction) among six participating teams. We also present type-based scores on preposition and article error correction and demonstrate that our approach achieves best performance in each task. 1
Catalytic Applications in the Production of Biodiesel from Vegetable Oils (2009)

The predicted shortage of fossil fuels and related environmental concerns have recently attracted significant attention to scientific and technological issues concerning the conversion of biomass into fuels. First-generation biodiesel, obtained from vegetable oils and animal fats by transesterification, relies on commercial technology and rich scientific background, though continuous progress in this field offers opportunities for improvement. This review focuses on new catalytic systems for the transesterification of oils to the corresponding ethyl/methyl esters of fatty acids. It also addresses some innovative/emerging technologies for the production of biodiesel, such as the catalytic hydrocracking of vegetable oils to hydrocarbons. The special role of the catalyst as a key to efficient technology is outlined, together with the other important factors that affect the yield and quality of the product, including feedstock-related properties and various system conditions.
[Interferons--its method of administration and adverse effect related to pharmacokinetics ]. (1984)

The potential role of interferons in the treatment of malignant diseases is currently being evaluated. This paper reviews experimental and clinical findings regarding pharmacokinetics, method of administration, and side reactions of interferons. Interferon in the blood is rapidly cleared from the circulation. Intramuscular injection of alpha-interferon causes low but stable interferon levels in the blood. However, in the case of beta-interferon, interferon is never detected consistently in the blood after intramuscular or subcutaneous administration. The studies with animal models suggest that doses higher than those given in current clinical trials will be necessary to obtain clearly beneficial effects in human. The maximum safely tolerated daily dose is appreciably higher than that used in most previous studies, although even at this level, considerable toxicity may be encountered. Adequate method of administration, route, dose and interval are not yet established at all. Exact mechanism of anticancer activity is not yet well defined. The most frequent side reaction is fever. However, the exact mechanism to cause these side reactions is also not yet clarified. Dose limiting central nervous system toxicities, hypotension, hypocalcaemia etc. are occasionally encountered in some instances. Antibody to interferon is demonstrated in some cases. Purification of interferon does not always causes reduction of side reactions. The treatment of cancer cases with interferon has just started and there are many problems to be solved. However, therapeutic beneficial may be achieved in the treatment of malignant tumors by appropriate combinations of interferon with conventional treatment. More laboratory studies as well as carefully controlled clinical observations are warranted.
Establishment and growth of sandalwood (<i>Santalum spicatum</i>) in south-western Australia: the Northampton pilot trial (1999)

Summary Direct seeding sandalwood (Santalum spicatum) beneath 1–2 year old host (Acacia acuminata) seedlings was found to be a successful establishment technique at Northampton. Mean survival of S. spicatum rows ranged from 50 to 87%. after 8–9 years. Growth was also good, with mean stem diameter increasing at a rate of 4–7 mm yr−1, and mean estimated stem weight gaining 0.28–0.46 kg yr−1, between 4.5 and 9 years. However, a high proportion of host trees had died, and the remaining trees were in poor health at the time of assessment (November 1997). After 10 years. A. acuminata survival in rows seeded with S. spicatum in 1988 was significantly lower than rows seeded in 1989. Differences in host survival between S. spicatum planting years may be due to the initial period of growth without a root parasite, or the S. spicatum to host ratio. Growth of S. spicatum was also variable between planting years and provenances. At age 5.5. mean tree height of the Hazelby's provenance (194 cm) was significantly taller than all other provenances (157 cm). The variability in growth rate may have been due to differences in rainfall between planting years or genetic differences between provenances. A selection program should be conducted to identify superior provenances or individual trees with desirable plantation characteristics, such as fast growth or high oil content. Plantations could be established in a range of locations in West- em Australia to test site suitability of different provenances.
Strategy for Population Triage Based on Dicentric Analysis (2009)

After large-scale accidental overexposure to ionizing radiation, a rapid triage of the exposed population can be performed by scoring dicentrics and ring chromosomes among 50 metaphases. This is rapid but is not accurate because the sensitivity is around 0.5 Gy. After the triage step, dose can be estimated by scoring 500 metaphases. This is lengthy but very accurate because the sensitivity is between 0.1 and 0.2 Gy. To improve the methodology, we propose the use of software for automatic dicentric scoring that was tested on victims of an accident in Dakar. Manual scoring of 50 metaphases was carried out, then manual scoring of 500 metaphases, and automatic scoring. Comparison between the dose classifications obtained with manual scoring on 50 metaphases and 500 metaphases showed 50% misclassification with the manual scoring on 50 metaphases. Comparison between the dose classifications obtained with the automatic scoring and manual scoring on 500 metaphases showed only 4.35% misclassification with the automatic scoring. The automatic scoring method is more accurate than the manual scoring on 50 metaphases and can therefore be used for triage, and in place of the manual scoring on 500 metaphases method for individual dose estimation, because it is as accurate and much faster.
Increased Cortisol Levels in Aging and Alzheimer's Disease in Postmortem Cerebrospinal Fluid (1994)

The hypothalamo-pituitary-adrenal (HPA) axis is activated during aging and even more so in dementia. Increased levels of corticosteroids may be neurotoxic. Therefore we have investigated cortisol levels in cerebrospinal fluid (CSF) of Alzheimer patients and controls. Ventricular postmortem CSF was collected from clinically and neuropathologically well-defined Alzheimer patients (n = 26) and control subjects (n = 21). In the group of Alzheimer patients the mean CSF total cortisol level was 83% higher than that in the controls. In presenile Alzheimer patients (< 65 years of age; n = 13) the CSF-cortisol level was 5 times higher than that of presenile controls (n = 7). In contrast, senile Alzheimer patients (n = 13) and controls of over 65 years of age (n = 14) did not show a significant difference in CSF-cortisol levels. The presence or absence of a difference in the cortisol-CSF levels in, respectively, presenile or senile Alzheimer patients as compared to controls was due to the 3.5-fold rise of CSF-cortisol in control subjects over 65 years of age as compared with controls under 65 years of age. The CSF-cortisol levels in presenile and senile Alzheimer patients were similar. No significant correlation was observed in the Alzheimer patients between age of onset of the dementia and CSF cortisol levels or duration of Alzheimer's disease and CSF cortisol levels. The finding that in senile Alzheimer patients cortisol levels were similar to those of unaffected age-matched controls does not seem to support the cortisol neurotoxicity hypothesis.(ABSTRACT TRUNCATED AT 250 WORDS)
Low-Power and Highly Uniform 3-b Multilevel Switching in Forming Free TiO<sub>2–<italic>x</italic></sub>-Based RRAM With Embedded Pt Nanocrystals (2016)

Multilevel capability is greatly desired in order to attain high effective memory density. Here, we demonstrate that 3-b per memory cell storage capacity can take place by incorporating small (~3 nm diameter) Pt nanocrystals (NCs) within 45-nm TiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2-x</sub> -based resistive random access memory. Seven low-resistance states as well one high-resistance state were achieved by setting proper compliance current (I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">cc</sub> ) limit between 2 and 200 μA. In striking contrast, the reference sample without NCs exhibited 2-b multilevel switching at higher operating voltages. The enhanced performance of the Pt NCs embedded sample is ascribed to the preferable creation of small conducting filaments around the NCs with high density of oxygen vacancies, due to the concentrated electric field effect, which improves the uniformity of the switching characteristics regardless of the random nature of switching effect.
Automatically Generating Algebra Problems (2021)

We propose computer-assisted techniques for helping with pedagogy in Algebra. In particular, given a proof problem p (of the form “Left-hand-side-term = Right-hand-side-term”), we show how to automatically generate problems that are similar to p. We believe that such a tool can be used by teachers in making examinations where they need to test students on problems similar to what they taught in class, and by students in generating practice problems tailored to their specific needs. Our first insight is that we can generalize p syntactically to a query Q that implicitly represents a set of problems [[Q]] (which includes p). Our second insight is that we can explore the space of problems [[Q]] automatically, use classical results from polynomial identity testing to generate only those problems in [[Q]] that are correct, and then use pruning techniques to generate only unique and interesting problems. Our third insight is that with a small amount of manual tuning on the query Q, the user can interactively guide the computer to generate problems of interest to her. We present the technical details of the above mentioned steps, and also describe a tool where these steps have been implemented. We also present an empirical evaluation on a wide variety of problems from various sub-fields of algebra including polynomials, trigonometry, calculus, determinants etc. Our tool is able to generate a rich corpus of similar problems from each given problem; while some of these similar problems were already present in the textbook, several were new!
El genero leptotyphlops en la coleccion de la fundacion miguel lillo (1984)

El autor, al observar caracteres inusuales como órganos de escamas y morfometría de placas de la cabeza, menciona 7 especies en el noroeste de Argentina, Leptotyphlops vellardi se describe como nueva. La validez de L. weyrauchi Orejas-Miranda es dudosa, mientras que tanto L. albipuncta (Jan) como L. striatula Smith y Laufe parecen distintas de L. melanotermus (Cope). La localidad tipo (Tucumán) de L. albipuncta se considera errónea, ya que no se encontró un solo espécimen entre la gran serie de Tucumán.
Determination of Spontaneous Mutation Frequencies in Measles Virus under Nonselective Conditions (2012)

There is a paradox between the remarkable genetic stability of measles virus (MV) in the field and the high mutation rates implied by the frequency of the appearance of monoclonal antibody escape mutants generated when the virus is pressured to revert in vitro (S. J. Schrag, P. A. Rota, and W. J. Bellini, J. Virol. 73:51-54, 1999). We established a highly sensitive assay to determine frequencies of various categories of mutations in large populations of wild-type and laboratory-adapted MVs using recombinant viruses containing an additional transcription unit (ATU) encoding enhanced green fluorescent protein (EGFP). Single and double mutations were made in the fluorophore of EGFP to ablate fluorescence. The frequencies of reversion mutants in the population were determined by measuring the appearance of fluorescence indicating a revertant virus. This allows mutation rates to be measured under nonselective conditions, as phenotypic reversion to fluorescence requires only either a single- or a double-nucleotide change and amino acid substitution, which does not affect the length of the nonessential reporter protein expressed from the ATU. Mutation rates in MV are the same for wild-type and laboratory-adapted viruses, and they are an order of magnitude lower than the previous measurement assessed under selective conditions. The actual mutation rate for MV is approximately 1.8 × 10(-6) per base per replication event.
Evidence for an Association between Thyroid-Stimulating Hormone and Insulin-Like Growth Factor 1 Receptors: A Tale of Two Antigens Implicated in Graves’ Disease (2008)

Thyroid-stimulating hormone receptor (TSHR) plays a central role in regulating thyroid function and is targeted by IgGs in Graves' disease (GD-IgG). Whether TSHR is involved in the pathogenesis of thyroid-associated ophthalmopathy (TAO), the orbital manifestation of GD, remains uncertain. TSHR signaling overlaps with that of insulin-like grow factor 1 receptor (IGF-1R). GD-IgG can activate fibroblasts derived from donors with GD to synthesize T cell chemoattractants and hyaluronan, actions mediated through IGF-1R. In this study, we compare levels of IGF-1R and TSHR on the surfaces of TAO and control orbital fibroblasts and thyrocytes and explore the physical and functional relationship between the two receptors. TSHR levels are 11-fold higher on thyrocytes than on TAO or control fibroblasts. In contrast, IGF-1R levels are 3-fold higher on TAO vs control fibroblasts. In pull-down studies using fibroblasts, thyrocytes, and thyroid tissue, Abs directed specifically against either IGF-1Rbeta or TSHR bring both proteins out of solution. Moreover, IGF-1Rbeta and TSHR colocalize to the perinuclear and cytoplasmic compartments in fibroblasts and thyrocytes by confocal microscopy. Examination of orbital tissue from patients with TAO reveals similar colocalization to cell membranes. Treatment of primary thyrocytes with recombinant human TSH results in rapid ERK phosphorylation which can be blocked by an IGF-1R-blocking mAb. Our findings suggest that IGF-1R might mediate some TSH-provoked signaling. Furthermore, they indicate that TSHR levels on orbital fibroblasts are considerably lower than those on thyrocytes and that this receptor associates with IGF-1R in situ and together may comprise a functional complex in thyroid and orbital tissue.