gebhart/patrepeval huggingface dataset:
<i>PEG10</i> Is a c-MYC Target Gene in Cancer Cells (2006)

The product of the imprinted gene paternally expressed gene-10 (PEG10) has been reported to support proliferation in hepatocellular carcinomas, but how this gene is regulated has been an open question. We find that MYC knockdown by RNA interference suppresses PEG10 expression in Panc1 pancreatic carcinoma and HepG2 hepatocellular carcinoma cells and that knockdown of PEG10 inhibits the proliferation of Panc1, HepG2, and Hep3B cells. Conversely, PEG10 was up-regulated by inducing c-MYC expression in a B-lymphocyte cell line. Chromatin immunoprecipitation from Panc1 cells showed c-MYC bound to an E-box-containing region in the PEG10 first intron and site-directed mutagenesis showed that the most proximal E-box is essential for promoter activity. In a mouse mammary tumor virus (MMTV)-MYC transgenic mouse model of breast cancer, most but not all of the mammary carcinomas had strongly increased Peg10 mRNA compared with normal mammary gland. By immunohistochemistry, normal human breast and prostate epithelium was negative for the major isoform [reading frame-1 (RF1)] of PEG10 protein, but this cytoplasmic protein was strongly expressed in a subset of breast carcinomas in situ and invasive ductal carcinomas ( approximately 30%) and in a similar percentage of prostate cancers. As in the mouse model, we found positive, but not absolute, correlations between PEG10 and c-MYC in tissue arrays containing 161 human breast cancers (P < 0.002) and 30 prostate cancers (P = 0.014). Immunostaining of human placenta showed PEG10 and c-MYC proteins coexpressed in proliferating cytotrophoblast and coordinately lost in postmitotic syncytiotrophoblast. These findings link cancer genetics and epigenetics by showing that a classic proto-oncogene, MYC, acts directly upstream of a proliferation-positive imprinted gene, PEG10.
Correct placement of endotracheal tube by single strand fiberoptic light in prematures. Initial clinical experience. (1991)

In order to reduce non radiographically improper placement of the endotracheal tube, we manufactured a single fiberoptic strand, connected to a high-intensity illuminator, to be introduced by reference marks up to the tip of conventional endotracheal tube. This system showed, in our initial clinical experience, confirmed by radiograms, to be non invasive and safe. Use of this method could be useful when the intubated premature is moved for necessary procedures, and a chest-X-ray film is not allowed. Infact, it permits the visualization of the tip of the endotracheal tube by a circle of light on the neck at the suprasternal notch. Furthermore, it results useful for all conventional tubes, without constant reduction in cross-sectional area or modification of mechanic characteristics of the tube wall.
『三國遺事』 諸條目間 關係考 (2001)

The specific aim of the present study is to examine the articles of 『samkuk-yusa』 from the view-point of the organic relation. Many of these articles...
Pasted‐Rolled Zinc Electrodes Containing Calcium Hydroxide for Use in Zn / NiOOH Cells (1987)

This paper discusses work to evaluate the durability of pasted‐rolled zinc electrodes prepared from a water‐based process in 26 Ah size zinc‐nickel oxide cells in 20 weight percent . An optimum Ca/Zn ratio of 0.58 was selected based upon data obtained using a potentiodynamic discharge technique and a specially designed small test cell to simulate a full size cell, experimental zinc electrodes with Ca/Zn ratios ranging from 0 to 0.8, SEM data, and zincate solubility considerations. The cells reached 400 to 550 cycles to 70% of the theoretical cell capacity. The loss in cell capacity seemed to be related mostly to a loss in utilization of the zinc electrode, and the shape change mechanism.
Sub-30-ps ECL circuit operation at liquid-nitrogen temperature using self-aligned epitaxial SiGe-base bipolar transistors (1991)

The authors report the operation of emitter coupled logic (ECL) circuits at liquid-nitrogen temperature using self-aligned epitaxial SiGe-base bipolar transistors. A minimum ECL gate delay of 28.1 ps at 84 K was measured; this is essentially unchanged from the room-temperature value of 28.8 ps at 310 K. This delay number was achieved under full logic-swing (500-mV) conditions and represents an improvement of greater than a factor of 2 over the best reported value for 84 K operation. Lower-power ECL circuits have switching speeds as fast as 51 ps at 2.2 mW (112-fJ power-delay product) at 84 K. These results suggest that silicon-based bipolar technology is suitable for very-high-speed applications in cryogenic computer systems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The Impact of Braille Reading Skills on Employment, Income, Education, and Reading Habits (1996)

This study compared a number of outcomes for congenitally legally blind adults who learned to read braille or print as their original reading medium. It was found that those who learned to read using braille had higher employment rates and educational levels, were more financially self-sufficient, and spent more time reading than did those who learned to read using print.
Two Processor Conservative Simulation Analysis (1992)

Abstract : We present some new models and their exact analysis for the problem of two processors running a conservative distributed simulation protocol. The models show that lookahead is very useful in gaining performance, but only if the processors are well balanced in processing capacity. The models allow quantitative evaluation of the improvement in speedup attributed to null messages, as well as the degradation due to a cost for breaking deadlocks. Finally, a conservative system with 'free' null messages and a small amount of lookahead is shown to outperform a Time Warp system with no cost for state saving or rollback.
Near-field laser-assisted localized crystal growth and nanodeposition (2004)

The ability to integrate nano-components onto MEMS devices in a controlled manner has been a limiting problem in interfacing micro-nano technologies, for the current methods of growing nano-structures/wires are inflexible and cannot be supported as a post-processing step for on-chip microelectronics. The main objective of this work is to selectively induce nucleation and further achieve crystal growth of silicon nano-structures/wires at specified sites without contaminating the outlining regions. A method utilizing a Q-switched, 532 nm, 10 Hz, Nd:YAG laser coupled to cantilevered NSOM fiber probes is proposed in this deposition experiment. A finite difference time domain simulation result is offered to illustrate the spatial confinement of the laser transmission field intensity emanating from the tip aperture. A vapor phase silane mixture (1% silane, 99% helium) was introduced into the vacuum chamber at pressures ranging from 200 to 440 Torr during the deposition experiments. The deposition and growth results for silicon nano-structure/wires on silicon substrates will be presented.
Morphology and compression‐after‐impact strength relationship in interleaved toughened composites (2003)

Abstract Morphology and compression after impact (CAI) strength relationships in interleaved toughened high performance composites are investigated using a quantitative two‐dimensional image analysis approach. A group of six quasi‐isotropic carbon fiber‐epoxy composites with identical compositions, but having variations in CAI strengths, were analyzed to study how the interleaf particle size, particle size distribution, and location of particles in the interlaminar region affect the CAI strength values and the corresponding damage mechanisms. It is found that the CAI strength of interleaved‐toughened composites is significantly affected by the size and size distribution of toughener particles in the interlaminar regions of the composite. In general, high CAI strength composites exhibit more uniform particle size distribution throughout the interlaminar regions. Whereas, for low CAI strength composites, the interleaf particles tend to cluster together and have varied size distribution.
La participación social en la ciencia española (2013)

Pulmonary fibrosis is a manifestation of the progression of interstitial pulmonary disease. Icariin (ICA) has been found to exhibit protective effects on multiple chronic diseases like diabetes, liver, heart, and renal fibrosis. Here, a systemic pharmacological study was designed to investigate whether ICA treatment alleviates bleomycin (BLM)-induced pulmonary fibrosis. The rat pulmonary fibrosis model was constructed by non-invasive endotracheal intubation instillation of BLM to observe the intervention effects of ICA on pulmonary fibrosis in the whole process of inflammation and fibrosis. ICA reduced the collagen deposition and inflammation induced by BLM in rat. The comparative RNA-sequencing was conducted to analyze the lung gene expression profiles in rat. KEGG analysis indicated that most of the genes were enriched in Hippo pathway, NF-κB pathway, and B-cell receptor signaling pathway, etc. Immunohistochemistry staining showed that the expression of YAP was significantly elevated in the model group and decreased in the ICA treatment group. Taken together, the anti-fibrotic effect of ICA appears to be mediated by its inhibitory of YAP, which is the core transcriptional regulator of Hippo pathway.
Cell production in the chicken cochlea (1989)

In the chicken cochlea, the structural features of the cilia bundles of individual hair cells vary systematically along the length of the sensory epithelium. As a first approach to understanding the developmental mechanisms that underlie this precise arrangement of structurally distinct hair cells, the spatiotemporal pattern of the terminal mitoses of their precursor cells was investigated by administering 3H-thymidine, a radioactive precursor to DNA. This demonstrated that the first hair cells were produced during the sixth day of incubation and formed a longitudinal band that extended along most of the length of the sensory epithelium. The epithelium grew further through appositional addition of hair cells at the edges of this first band of cells, and the hair cell addition process expanded into the surrounding areas during the next 3 days. By the ninth day of incubation all the hair cells in the sensory epithelium except for those at the peripheral edges in the distal (apex) portion had been produced through terminal mitoses. Our results have demonstrated that hair cells that have similar stereocilia phenotypes do not all leave the mitotic cycle at the same time.
Integrating and Accessing Heterogeneous Information Sources in TSIMMIS (1994)

The goal of the Tsimmis Project is to develop tools that facilitate the rapid integration of heterogeneous information sources that may include both structured and unstructured data. This paper gives an overview of the project, describing components that extract properties from unstructured objects, that translate information into a common object model, that combine information from several sources, and that allow browsing of information.
PRELIMINARY RESULTS OF A PHASE II STUDY OF ORAL THALIDOMIDE IN PATIENTS WITH HIV INFECTION AND KAPOSI'S SARCOMA (KS) (1997)

Background: Neovasularization and angiogenesis are important in the pathogenesis of Kaposi's sarcoma (KS). Thalidomide is an oral drug that has been shown by D'Amato, Folkman et al. to inhibit angiogenesis in a rabbit cornea assay (PNAS 91:4082, 1994). It has immunomodulatory properties but rarely causes neutropenia. Methods: A phase Il trial was initiated of oral thalidomide administered over six months. Entry requirements included cutaneous KS lesions with evidence of disease progression in the two previous months. Dosing started'at 200 mg/day (taken at bedtime) with escalation every two weeks if tolerated to a maximum of 1000 mg/day. A slight modification of the AIDS Clinical Trials Group KS criteria was utilized to assess responses. Results: Five patients have accrued to date. Three (3/5) have now attained partial responses; in each case, this was on the basis of a ≥50% decrease in the number of nodular lesions, sustained for at least four weeks. These responses were first observed at weeks four (2/5) and eight (1/5) at daily doses of 200 mg, 400 mg, and 800 mg. One of these patients also had psoriasis that appeared to improve along with the KS. Two patients (2/5) had progressive disease. Two patients tolerated the 1000 mg dose level without difficulty while three required dose reductions due to sedation, which was the only dose-limiting toxicity. Two of these three subsequently tolerated a dose of 600 mg/day, while the third could only tolerate 300 mg/day. Other toxicities were not dose-limiting: four patients experienced a grade one peripheral neuropathy; one patient briefly experienced mild constipation; and one patient had a transient grade three neutropenia that resolved spontaneously. Conclusions: Thalidomide is well-tolerated by patients with RIV-associated KS at doses as high as 1000 mg/day. Preliminary results suggest that it may have anti-KS activity. Updated results will be presented at the conference.
Nature of the electronic interactions in aryl-substituted polysilanes (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNature of the electronic interactions in aryl-substituted polysilanesC. G. Pitt, R. N. Carey, and E. C. Toren Jr.Cite this: J. Am. Chem. Soc. 1972, 94, 11, 3806–3811Publication Date (Print):May 1, 1972Publication History Published online1 May 2002Published inissue 1 May 1972https://pubs.acs.org/doi/10.1021/ja00766a024https://doi.org/10.1021/ja00766a024research-articleACS PublicationsRequest reuse permissionsArticle Views167Altmetric-Citations92LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
An Ultrastructural Study of the Retention Hyperkeratosis of Experimentally Induced Comedones in Rabbits: The Effects of Three Comedolytics (1996)

The precise pathologic processes of comedo formation in acne are not well understood. Retention hyperkeratosis may play an important role. To evaluate the effects of three topical comedolytics, 20% azelaic acid, 0.1% tretinoin and 5% benzoyl peroxide, on the retention hyperkeratosis of experimentally induced comedones (EIC), an ultrastructural study was done. After formation of EIC with 50% oleic acid in paraffin oil on the external ears of rabbits, each comedolytic was applied for 4 weeks. Biopsies were taken every week and, using a Hitachi H-600 transmission electron microscope, morphologic observations were done in the upper portion of the follicular epithelium. In EIC, after application of each comedolytic, the markedly thinned horny layer was loosely adhered by extremely few desmosomes and desmosomal bodies. The number and size of tonofilaments and keratohyaline granules decreased, but the number of variable sized Odland bodies increased in the upper epidermis. These findings appeared 1 week after application of either azelaic acid or benzoyl peroxide, and 3 weeks after application of tretinoin. For the first 2 weeks of tretinoin application, EIC showed rather compact hyperkeratosis with more desmosomes and desmosomal bodies than before. Azelaic acid tretinoin and benzoyl peroxide increased the number of Odland bodies, and the horny cells became less adhesive. This lysis of retention hyperkeratosis resulted in comedolysis. During 4 weeks of treatment with these three comedolytics, only tretinoin normalized the keratinization process.
Flavopiridol enhances the effect of docetaxel in vitro and in vivo in human gastric cancer cells. (2003)

Gastric cancer is one of the leading causes of cancer death throughout the world. It is a disease in desperate need of new therapeutic approaches. Docetaxel, a semisynthetic taxane, has shown potent activity against a broad range of solid tumors. However, in gastric cancer, response rates to docetaxel remain only approximately 20%. In these studies we show that flavopiridol, a cyclin-dependent kinase inhibitor, potentiates docetaxel-induced apoptosis 3-fold in MKN-74 human gastric cells. This effect is sequence dependent, such that flavopiridol must follow docetaxel to induce this effect. Docetaxel induces transient arrest in the M phase of the cell cycle. Cells exit mitosis in a specific time window without cytokinesis with a decrease in cyclin B1/cdc-2 kinase activity and MPM-2 labeling. Flavopiridol treatment of docetaxel-treated cells enhances the exit from mitosis with a more rapid decrease in mitotic markers including MPM-2 labeling and cyclin B1/cdc2 kinase activity. In contrast, pretreatment with flavopiridol prevents cells from entering mitosis by inhibiting cyclin B1/cdc-2 kinase activity, thus antagonizing the docetaxel effect. The testing of this combination against MKN-74 xenografts confirms the sequence dependency. Treatment of MKN-74 tumor-bearing xenografts with docetaxel at a dose of 10 mg/kg followed 3-7 h later by flavopiridol at a dose of 2.5 mg/kg resulted in a 1-18% decrease in tumor volume. In contrast, treatment with docetaxel alone at this same dose resulted in a 394% increase in tumor volume. When flavopiridol was given immediately after docetaxel, the effect was not statistically different from that of docetaxel alone. The reverse combination of flavopiridol followed 7 h later by docetaxel was similar to treatment with docetaxel alone. Flavopiridol alone had no effect in this tumor model. Thus, flavopiridol, when combined with docetaxel in a sequence-specific manner, may provide a completely new therapeutic approach in the treatment of gastric cancer.
Use of self-expanding stents in distal small cerebral vessels. (2007)

Development of newer low-profile endovascular devices allows access and ability to treat lesions farther out in the smaller cerebral vessels. We have safely and successfully treated 8 vessels smaller than 2 mm in diameter with newer self-expanding stents with good short- and intermediate-term results. Further follow-up and more experience are necessary to determine long-term results.
Dual Effects of miR156-Targeted <i>SPL</i> Genes and <i>CYP78A5/KLUH</i> on Plastochron Length and Organ Size in <i>Arabidopsis thaliana</i>     (2008)

Leaves of flowering plants are produced from the shoot apical meristem at regular intervals, with the time that elapses between the formation of two successive leaf primordia defining the plastochron. We have identified two genetic axes affecting plastochron length in Arabidopsis thaliana. One involves microRNA156 (miR156), which targets a series of SQUAMOSA PROMOTER BINDING PROTEIN-LIKE (SPL) genes. In situ hybridization studies and misexpression experiments demonstrate that miR156 is a quantitative, rather than spatial, modulator of SPL expression in leaf primordia and that SPL activity nonautonomously inhibits initiation of new leaves at the shoot apical meristem. The second axis is exemplified by a redundantly acting pair of cytochrome P450 genes, CYP78A5/KLUH and CYP78A7, which are likely orthologs of PLASTOCHRON1 of rice (Oryza sativa). Inactivation of CYP78A5, which is expressed at the periphery of the shoot apical meristem, accelerates the leaf initiation rate, whereas cyp78a5 cyp78a7 double mutants often die as embryos with supernumerary cotyledon primordia. The effects of both miR156-targeted SPL genes and CYP78A5 on organ size are correlated with changes in plastochron length, suggesting a potential compensatory mechanism that links the rate at which leaves are produced to final leaf size.
Cardiac ventricular chambers are epigenetically distinguishable (2010)

The left and right ventricles are muscular chambers of the heart that differ significantly in the extent of pressure work-load. The regional and differential distribution of gene expression patterns is critical not only for heart development, but, also in the establishment of cardiac hypertrophy phenotypes. the cells of the myocardium employ elaborate regulatory mechanisms to establish changes in chromatin structure and function, yet, the role of epigenetic modifications and specific gene expression patterns in cardiac ventricles remains poorly understood. We have examined gene expression changes and studied histone H3 and H4 acetylation as well as dimethylation of lysine 4 on histone H3 on promoters of alpha-Myosin heavy chain gene (alpha-MHC), beta-Myosin heavy chain gene (beta-MHC), Atrial natriuretic peptide gene (ANp), B-type natriuretic peptide gene (BNP) and Sarcoplasmic reticulum Ca(2+) ATPase gene (SERCA2a). The recruitment of histone acetyltransferase (HAT) enzyme p300, which is a transcriptional coactivator, was also studied on the hyperacetylated promoters using immunopurification of soluble chromatin in the left and right ventricles of the mouse. We present evidence for the first time that the pattern of gene expression is closely linked with histone modifications and propose the left and right chambers of the heart are epigenetically distinguishable.
Instabilities and Pattern Transformation in Periodic, Porous Elastoplastic Solid Coatings (2008)

Pattern transformation in periodic microporous elastoplastic solid coatings is caused by a buckling of the struts and a rotation of the nodes under compressive stresses. The results of a nonlinear numerical investigation confirm the critical role of the bifurcation of the periodic solid under compressive stresses. In striking contrast to the earlier observations of elastic instabilities in porous elastomeric solids, the elastic-plastic nature of the cross-linked periodic microstructure studied here provides the ability to lock in the transformed pattern with complete relaxation of the internal stresses. The study unveils a novel deformation mode in porous periodic solids in the form of organized buckling instability of weak strut elements.
A Bayesian approach to reconstruction from incomplete projections of a multiple object 3D domain (1989)

An estimation approach is described for three-dimensional reconstruction from line integral projections using incomplete and very noisy data. Generalized cylinders parameterized by stochastic dynamic models are used to represent prior knowledge about the properties of objects of interest in the probed domain. The object models, a statistical measurement model, and the maximum a posteriori probability performance criterion are combined to reformulate the reconstruction problem as a computationally challenging nonlinear estimation problem. For computational feasibility, a suboptimal hierarchical algorithm is described whose individual steps are locally optimal and are combined to satisfy a global optimality criterion. The formulation and algorithm are restricted to objects whose center axis is a single-valued function of a fixed spatial coordinate. Simulation examples demonstrate accurate reconstructions with as few as four views in a 135 degrees sector, at an average signal-to-noise ratio of 3.3.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>