gebhart/patrepeval huggingface dataset:
Boundary Constrained Modal Test Method for Large Scale Highly Flexible Structures (2012)

Traditionally, the method of low stiffness suspension is a standard method for the modal test of structures. A requirement on the suspension stiffness is that the suspension frequency should be much lower than the first flexible natural frequency of the tested structure. Nevertheless, for large scale structure with very low first natural frequency, which could be as low as 0.1Hz, it will need very long suspension spring to achieve the required frequency. This may be not acceptable for many labs. Even if there is sufficient high room space for the suspension, the test is, strictly speaking, two dimensional, i.e. in the plane defined by the suspension. In this paper, we discuss existing methods for coping with these problems by replacing the low stiffness suspension with a group of supports that can have any stiffness. By removing the influence of the support stiffness from a later computation with measured frequency responses, the three dimension modal test can be done conveniently. Numerical examples are described in the paper.
Transcription factor binding sites in the matrix attachment region (MAR) of the chicken α‐globin gene (1994)

Nuclear matrix is a nuclear protein-DNA superstructure believed to be the exclusive site of DNA replication, transcription, repair, and recombination. The attachment regions of chromatin loops to the nuclear matrix, called MARs, nest origins of replication, have transcriptional enhancer activity, and via their interaction with protein transcription factors may govern gene switch during development and tissue-specific gene expression. In this study the 967 bp MAR of the chicken alpha-globin gene is analyzed for the presence of hexanucleotides from a number (83 in total) of vertebrate protein transcription factors and core origins of replication. A total number of 760 hexanucleotides from factor sites or origins of replication were used for this search. We found that: (1) The occurrence of protein transcription factor binding sites overall on the MAR fragment as well as on the enhancer and promoter regions of other genes is only about 1.2-1.5 times higher than in random DNA, something consistent for all MAR and enhancer sequences examined. However, a high concentration (up to 2.7 times over random sequences) of hexanucleotide factor sites is observed on small stretches of the alpha-globin gene MAR. (2) Some regulatory protein binding sites are underrepresented whereas others are overrepresented, giving to an MAR a particular transcription factor flavor. (3) The DNA curvature map of the MAR sequence and the potential sites of positioned nucleosomes suggest the sites where a competition between core histone octamers and protein transcription factors for DNA might be found. This approach might provide a novel technique to diagnose for the regulatory or nonregulatory function of a stretch of DNA. Furthermore, MARs are proposed to constitute important regulatory elements of genes in addition to enhancers, promoters, silencers, locus control regions, and origins of replication. Additional parameters such as interaction of a transcription factor with other transcription factors fixed at vicinal sites, DNA methylation, intrinsic DNA curvature torsional strain, and nucleosome positioning might also determine the high-affinity binding of a transcription factor to its functional sites and its exclusion from or low affinity binding to other nonregulatory regions.
Application of a highly specific and sensitive fluorescent HPLC method for topotecan lactone in whole blood (2009)

Individualization of topotecan dosing reduces inter-patient variability in topotecan exposure, presumably reducing toxicity and increasing efficacy. However, logistical limitations (e.g. requirement for plasma, intensive bedside plasma processing) have prevented widespread application of this approach to dosing topotecan. Thus, the objectives of the present study were to develop and validate an HPLC with fluorescence detection method to measure topotecan lactone in whole blood samples and to evaluate its application to individualizing topotecan dosing. Plasma samples (200 microL) were prepared using methanolic precipitation, a filtration step and then injection of 100 microL of the methanolic extract onto a Novapak C(18), 4 microm, 3.9 x 150 mm column with an isocratic mobile phase. Analytes were detected with a Shimadzu Fluorescence RF-10AXL detector with an excitation and emission wavelength of 370 and 520 nm, respectively. This method had a lower limit of quantification of 1 ng/mL (S/N >or= 5; RSD 4.9%) and was validated over a linear range of 1-100 ng/mL. Results from a 5-day validation study demonstrated good within-day and between-day precision and accuracy. Data are presented to demonstrate that the present method can be used with whole blood samples to individualize topotecan dosing in children with cancer.
The <i>gadd</i> and <i>MyD</i> Genes Define a Novel Set of Mammalian Genes Encoding Acidic Proteins That Synergistically Suppress Cell Growth (1994)

A remarkable overlap was observed between the gadd genes, a group of often coordinately expressed genes that are induced by genotoxic stress and certain other growth arrest signals, and the MyD genes, a set of myeloid differentiation primary response genes. The MyD116 gene was found to be the murine homolog of the hamster gadd34 gene, whereas MyD118 and gadd45 were found to represent two separate but closely related genes. Furthermore, gadd34/MyD116, gadd45, MyD118, and gadd153 encode acidic proteins with very similar and unusual charge characteristics; both this property and a similar pattern of induction are shared with mdm2, whic, like gadd45, has been shown previously to be regulated by the tumor suppressor p53. Expression analysis revealed that they are distinguished from other growth arrest genes in that they are DNA damage inducible and suggest a role for these genes in growth arrest and apoptosis either coupled with or uncoupled from terminal differentiation. Evidence is also presented for coordinate induction in vivo by stress. The use of a short-term transfection assay, in which expression vectors for one or a combination of these gadd/MyD genes were transfected with a selectable marker into several different human tumor cell lines, provided direct evidence for the growth-inhibitory functions of the products of these genes and their ability to synergistically suppress growth. Taken together, these observations indicate that these genes define a novel class of mammalian genes encoding acidic proteins involved in the control of cellular growth.
Portfolio optimization under l/sub ∞/ risk measure (2002)

In this paper, a new model for portfolio selection is introduced to address the situation where a risk averse investor wants to minimize the maximum individual risk among assets to be invested. The model uses an l/sub /spl infin// function as a risk aversion measure. This differs from previous studies where either an l/sub 2/ function or an l/sub 1/ function is suggested, which may not model the concern of very cautious investors properly. We formulate our problem as a bi-criteria piecewise linear program, where one criterion is to minimize the l/sub /spl infin// risk function while the other is to maximize the total expected return. This bi-criteria optimization problem is converted into an equivalent scalarized problem with a single combined criterion. An interesting finding is that an optimal solution to the scalarized optimization problem can be derived analytically. The solution exhibits a simple structure, which selects successively assets to be invested in accordance with the ratio of the difference in their return rates to their risks.
Three-Dimensional Imaging Using A Single Laser Pulse (1989)

We describe results from an optical detector capable of producing three-dimensional images using single laser pulses. The method consists of detecting reflected light from an object illuminated by a short pulse from a laser with a detector that resolves many pixels in the object's image into fine time bins equivalent to range resolution of 4 cm. The detector utilizes a fiber optic image converter to transform a square focal plane into a line array that is input to a streak camera to obtain high time resolution in all the pixels. We show data from simple objects, like posts and cones, as well as more complicated objects. This work builds upon our results reported in September 1988 at the Laser Radar III SPIE conference. In that work we imaged the entire object to a point that was a single input to the streak camera. In addition we viewed the object from many aspect angles and used the range measurements to produce a two-dimensional projection image of the object. That method of reflective tomography requires gathering data from many aspect angles while the method reported here, which we call angle-angle-range, provides a three-dimensional image with data from a single aspect angle using a single laser pulse. Here we will compare the methods in detail.
Preparation, Structure, and Properties of Surface Modified Graphene/Epoxy Resin Composites for Potential Application in Conductive Ink (2018)

The dispersity of graphene (GE) in the matrix has an important influence on the thermal, mechanical, and electrical properties of its derived composites. In this paper, surface modification with a silane coupling agent and a double injection method were used to improve the dispersity of GE in epoxy resin (EP). The thermal, mechanical, and electrical properties of modified graphene/epoxy resin composites (modified GE/EP) were investigated by the thermogravimetric analysis, a four-probe method, and the tensile and bending strength. The results reveal that these properties of the composites can be improved significantly by using the modified GE as the filler. The surface of the modified GE/EP composite was smooth when the curing temperature was 75 °C. The weight loss of the modified GE/EP composite was lower than that of pure EP. The tensile and bending strength of modified GE/EP-0.07 (0.07 wt % modified GE) reached 74.65 and 106.21 MPa, respectively. In addition, the resistivity of modified GE/EP-0.1 (0.1 wt % modified GE) decreased to 52 Ω·cm, which was lower than that of CB/EP-1 (1 wt % carbon black, 95 Ω·cm) and Ag/EP-50 (50 wt % Ag particles, 102 Ω·cm). It is worth noting that the percolation threshold of the modified GE/EP composites was 0.025 vol % modified GE. These results show that the modified GE/EP composites have a potential application in conductive ink when the modified GE is used as the conductive filler.
Polymers in medicine III : proceedings of the Third International Conference on Polymers in Medicine, Porto Cervo, Italy, June 9-13, 1987 (1988)

Biomedical Polymers. A new material for biomedical application (R. Barbucci et al.). Bioresorbably polyesters from bacterial polymerization reactions (R.W. Lenz et al.). Novel biodegradable poly(ether-esters): composition, morphology and in-vitro degradation (H. Younes, D. Cohn). Synthesis and characterization of new tertiary amino polymers (P. Ferruti, E. Ranucci). Plasma-modified polymers for biomedical applications (D. Cohn). The activation of human plasma prekallikrein as a haemocompatibility test for biomaterials. I. Results obtained with the ``end-point'' method (P. Giusti et al.). Grafting of poly(ethylene glycol) on cellulose surfaces and the subsequent decrease of the complement activation (E. Corretge et al.). A selectively biodegradable vascular graft (D. Cohn et al.). On the measurement of permeability of polymers to dissolved oxygen (L. Nicodemo et al.). Surface analysis of biomedical materials by ESCA and SIMS (B.D. Ratner). A systematic study of proteins adsorbed on hemodialysis membranes after their clinical use (M.C. Tanzi et al.). A novel approach to the problem of heparin in hemodialysis: the use of a deheparinizing filter (M.A. Marchision et al.). Effects of ``in vivo'' PMMA pressure injection (F. Franchin et al.). Analogous hydroxyapatite reinforced polymers for bone replacement (W. Bonfield). Polymer Drug and Drug Delivery Systems. Preparation and evaluation of lactide/glycolide copolymers for drug delivery (R.L. Dunn et al.). Thermally reversible hydrogels containing biologically active species (A.S. Hoffman). Modified release tablet formation (P. Catellani et al.). Chemically self-regulated drug delivery systems (J. Heller et al.). Polymeric prodrug systems based on poly(N-vinylpyrrolidone-alt-maleic anhydride) (M. Azori). A multiple unit modified release system (A. Gazzaniga et al.). Inserts for sustained ocular delivery of pilocarpine: Evaluation of a series of partial esters of (maleic acid-alkyl vinyl ether) alternating copolymers (M.F. Saettone et al.). Soluble polymers or insoluble matrices to facilitate the use of arginase in therapy (F.M. Veronese et al.). Keyword Index.
Severe Myoclonic Epilepsy of Infants (Dravet Syndrome): Natural History and Neuropsychological Findings (2006)

Severe Myoclonic Epilepsy in infancy (SMEI, or Dravet syndrome) is a drug-resistant epilepsy that occurs in the first year of life of previously healthy children. The main clinical features are prolonged and repeated febrile and afebrile generalized or unilateral convulsive seizures. In the course of the epilepsy, cognitive deterioration becomes evident, and interictal myoclonus, clumsiness and ataxia appear. One third of the children with SMEI show de novo mutations of the SCN1A gene, and additional familial genes probably contribute to the phenotype. While the clinical picture of SMEI has been well studied, neuropsychological data remain scarce. Global mental retardation, attention deficit and psychotic behavior have been reported but the long-term outcome has not been evaluated. We conducted a longitudinal neuropsychological study of children with SMEI. Twenty children, aged 11 months to 16 years, were prospectively examined using standardized neuropsychological tests. Correlation analysis with other clinical features was performed in 12 cases. Marked slowing or stagnation of psychomotor development, accompanied by psychotic or autistic traits and hyperactivity, was observed between the ages of one and four years. In the later stages (at ages 5 to 16 years), cognitive function stabilized but remained below normal. In children with a more favorable course, language capacities were better preserved than visuospatial functions, and behavior improved. The cognitive and behavioral impairment tended to correlate with the frequency of convulsive seizures (>5 per month). The data suggest that SMEI can be considered as a prototype of an epileptic encephalopathy.
Understanding large system failures-a fault injection experiment (2003)

Fault injection is used to characterize large system failures. Thus, it overcomes limitations imposed by the lack of complete information in field failure data. The experiment is conducted on a commercial transaction processing system. The authors: (1) introduce the idea of failure acceleration to conduct such experiments; (2) estimate total loss of the primary service to occur in only 16% of the faults; (3) reveal errors termed potential hazards that do not affect short-term availability but cause a catastrophic failure following a change in operating state; and (4) identify at least 41% of errors as potential candidates for repair before total failure. The results enhance the understanding of large system failures and provide a foundation for design enhancements and modeling of availability.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Movement of metolachlor in soil: effect of new organo-clay formulations (1999)

The use of commercially available formulations of metolachlor has resulted in its leaching and migration to water sources. Formulations of metolachlor designed to reduce its leaching in soil have been prepared by adding the herbicide dissolved in an organic solvent or in water to organo-clay complexes. Best formulations were made when the organo-clay complex was formed by adsorbing the monovalent organic cations benzyltrimethylammonium (BTMA) or benzyltriethylammonium (BTEA) onto sodium montmorillonite (Mont) at 0.5 or 0.8 mole kg−1 clay. Adsorption of metolachlor to organo-clays followed the sequence Mont-BTMA 0.5 > Mont-BTMA 0.8 > Mont-BTEA 0.8 > Mont-BTEA 0.5 > Mont. Fourier transform infrared (FTIR) analysis demonstrated the occurrence of shifts of several peaks of adsorbed metolachlor relative to the free herbicide, indicating the existence of strong interactions between metolachlor molecules and the organo-clay surface. Leaching studies employing organo-clay and commercial formulations were carried out under greenhouse and field conditions. Metolachlor applied as organo-clay formulations leached less than the commercial formulation. Organo-clay formulations prepared by adding the herbicide as a water solution showed less leaching in the soil profile than those made by using organic solvent. Under greenhouse conditions, the herbicidal activity of organo-clay formulations was similar to that of the commercial one. Under field conditions, leaching from Mont-BTMA 0.5-metolachlor was less than that from the commercial formulation, demonstrating the environmental and agricultural advantages of the organo-clay formulations of metolachlor. © 1999 Society of Chemical Industry
Highly conformal and adhesive electroless barrier and Cu seed formation using nanoparticle catalyst for realizing a high aspect ratio cu-filled TSV (2013)

A conformal diffusion barrier was formed in a high aspect ratio through-silicon via (TSV) using electroless plating. Dense adsorption of Pd nanoparticle catalyst on SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> assisted the formation of a thin electroless CoWB layer, on which an electroless Cu seed layer could be deposited. The adhesion strength of the CoWB layer was improved with addition of adequate amount of saccharine and conformal deposition property was obtained with addition of SPS.
Time-varying spectral analysisfor radar imaging of manoeuvring targets (1998)

Fourier transforms are the basis for conventional radar range-Doppler imaging. Target rotation during the coherent integration time results in a time-varying Doppler frequency shift that produces, after Fourier transform, a smeared Doppler spectrum and a blurred image. Sophisticated motion compensation algorithms must be applied to obtain focused images using Fourier techniques. However, image blurring can be mitigated without resorting to sophisticated focusing algorithms by using time-varying spectral analysis in place of the Fourier analysis for Doppler processing. Various methods of time-varying spectral analysis are described and compared. Range-Doppler images of manoeuvring aircraft produced by conventional Fourier analysis are then compared with those produced by time-varying spectral analysis. A quantitative simulation illustrates the benefit of using the latter.
Management of Menorrhagia Associated with Chemotherapy‐Induced Thrombocytopenia in Women with Hematologic Malignancy (2011)

Abnormal uterine bleeding in women with a blood dyscrasia, such as leukemia, or who experience thrombocytopenia secondary to myelosuppressive chemotherapy is a clinical condition associated with significant morbidity. Consequently, effective management is necessary to prevent adverse outcomes. Prevention of menorrhagia, defined as heavy regular menstrual cycles with more than 80 ml of blood loss/cycle or a cycle duration longer than 7 days, in this patient population is the goal of therapy. Gonadotropin-releasing hormone analogs (e.g., leuprolide) are promising therapies that have been shown to decrease vaginal bleeding during periods of thrombocytopenia and to have minimal adverse effects other than those associated with gonadal inhibition. In patients who experience menorrhagia despite preventive therapies, or in patients who have thrombocytopenia and menorrhagia at diagnosis, treatment is indicated. For these women, treatment options may include platelet transfusions, antifibrinolytic therapy (e.g., tranexamic acid), continuous high-dose oral contraceptives, cyclic progestins, or other therapies for more refractory patients such as danazol, desmopressin, and recombinant factor VIIa. Hormonal therapies are often the mainstay of therapy in women with menorrhagia secondary to thrombocytopenia, but data for these agents are sparse. The most robust data for the treatment of menorrhagia are for tranexamic acid. Most women receiving tranexamic acid in randomized trials experienced meaningful reductions in menstrual bleeding, and this translated into improved quality of life; however, these trials were not performed in patients with cancer. Further clinical trials are warranted to evaluate both preventive and therapeutic agents for menorrhagia in premenopausal women with cancer who are receiving myelosuppressive chemotherapy.
Antifibrillatory actions of HBI‐3000 in the conscious canine model of sudden cardiac death (2009)

The antifibrillatory actions of HBI‐3000 (sulcardine sulfate) were studied in a conscious canine model of sudden cardiac death (SCD). Female purpose‐bred beagles were anesthetized, and left ventricular anterior wall ischemic injury was induced by a 90 minute occlusion followed by reperfusion of the left anterior descending coronary artery. Three to seven days later, the dogs were randomized into two groups: Group 1 (n = 8) received 0.9% NaCl solution for injection while Group 2 (n = 7) received 15 mg/kg of HBI‐3000 intravenously. The dogs were subjected to anodal current‐induced injury of the circumflex coronary artery, resulting in transient interruptions in coronary artery blood flow and posterolateral myocardial ischemia. The electrocardiogram confirmed the presence of regional myocardial ischemia and ventricular fibrillation (VF). Control animals developed premature ventricular complexes (PVC) followed by ventricular tachycardia, which terminated in VF in four of the eight dogs and one expired overnight. PVC was also observed in HBI‐3000 treated animals, but only one of the seven animals developed VF in SCD (p < 0.05 vs. control). The data indicate that HBI‐3000 is effective in reversing polymorphic ventricular arrhythmias and has favorable antifibrillatory actions in the post‐infarcted canine heart subjected to a remote ischemic event. Supported by HUYA Bioscience International.
Development of a Finite Element Model of Warping Inflatable Wings (2006)

This paper presents development of a structural model of warping inflatable wings. In order to quickly and effectively analyze the effects of aerodynamic loading and to consider design options for warping actuation, a detailed finite element model is required. The methodology used to develop and initially validate a finite element model of an inflatable wing is described in this paper. The wing is a complex structural system including intricate geometry, internal pressurization and a woven fabric shell structure. This effort includes determination of material properties via laboratory tests. These are verified with finite element simulations of simple inflatable cylinders constructed of similar material. The process used to create a finite element simulation of the wing is presented, including modeling assumptions and nonlinear analysis stages. Results for various loadings of interest are included. Finally, the paper presents initial validation of the finite element model using results of static cantilever wing bending and twisting loads applied at the inflatable wing tip. Although the model represents important deformation characteristics of the inflatable wing, it is generally too stiff compared to experimental results. Future modifications to the model and further validation are also discussed.