gebhart/patrepeval huggingface dataset:
[Effects of acidic polysaccharide from Holothuria leucospilota on platelet aggregation in rabbits]. (1987)

Platelet aggregations induced by acidic polysaccharide from Holothuria leucospilota (Brandt) (HL-P) 2.56-320μg/ ml in vitro and 2 mg/kg iv were observed in rabbits. The results showed that HL-P had no effect on the aggregation of platelet treated with anticoagulants, trisodium citrate or EDTA-Na2, and could mildly induce the aggregation of platelet treated with heparin. A significant proaggregatory effect on blood platelet suspended in modified Tyrode’ s solution was caused by HL-P, and potentiated by Ca2+ and Mg2+. HL-P prompted ADP-induced platelet aggregation to a certain extent. However, HL-P produced a very significant inhibition on thrombin-induced platelet aggregation. The amount of platelets was diminished by HL-P.
Magnetic film memory systems (1968)

The factors which must be considered in a magnetic film memory system design are enumerated. Particular attention is given to optimizing the amount of flux in a storage cell and the minimum signal requirements. The analyses performed indicate that memory size, memory speed, memory organization, and integrated circuit drive capability determine optimum requirements for storage flux in a magnetic cell. Thermal noise in the sensing system establishes a minimum signal level as a function of memory speed and amplifier bandwidth.
Basal-State Hyperinsulinemia in Healthy Normoglycemic Adults Is Predictive of Type 2 Diabetes Over a 24-Year Follow-Up (2009)

OBJECTIVE We examined the predictive value of hyperinsulinemia in the basal state on the 24-year progression from normoglycemia to dysglycemia. RESEARCH DESIGN AND METHODS A sample of 515 normoglycemic men and women were studied again after 24 years for glycemic status. RESULTS Half of the participants developed dysglycemia: 11.1% progressed to impaired fasting glucose (IFG), 9.9% to impaired glucose tolerance (IGT), 4.5% to both IFG and IGT, and another 24.3% to type 2 diabetes. Elevated levels of overnight fasting (basal) insulin, triglycerides, BMI > or =27 kg/m(2), fasting blood glucose, blood pressure, North African or Yemenite background, and male sex each favored conversion to dysglycemia after 24 years. In multiple ordered logistic regression analysis, the most significant predictor of progression to dysglycemia was hyperinsulinemia (upper quintile), after adjusting for BMI, ethnic origin, sex, age, smoking, physical activity, blood pressure, and triglycerides. CONCLUSIONS Basal hyperinsulinemia in normoglycemic adults constitutes an independent risk factor for developing dysglycemia over 24 years.
Affinity of mismatch-binding protein MutS for heteroduplexes containing different mismatches (2001)

We have used bandshift analysis to measure the interaction between the Escherichia coli mismatch-binding protein MutS and synthetic DNA fragments containing all possible DNA mismatches as well as an unpaired T (∆T). The order of affinity is found to be ∆T &gt; GT &gt; GG &gt; AA ≈ TT ≈ TC&gt;CA&gt;GA &gt; CC&gt;GC. We find that the affinity for GT mismatches is affected by the flanking sequence and decreases in the order GnCn&gt;(GC)n&gt;AnTn&gt;(AT)n. Studies with base analogues show good binding to φT (where φ represents 1′,2′-dideoxyribose), but much weaker binding to Gφ.
Error Assessment of Solar Irradiance Forecasts and AC Power from Energy Conversion Model in Grid-Connected Photovoltaic Systems (2015)

Availability of effective estimation of the power profiles of photovoltaic systems is essential for studying how to increase the share of intermittent renewable sources in the electricity mix of many countries. For this purpose, weather forecasts, together with historical data of the meteorological quantities, provide fundamental information. The weak point of the forecasts depends on variable sky conditions, when the clouds successively cover and uncover the solar disc. This causes remarkable positive and negative variations in the irradiance pattern measured at the photovoltaic (PV) site location. This paper starts from 1 to 3 days-ahead solar irradiance forecasts available during one year, with a few points for each day. These forecasts are interpolated to obtain more irradiance estimations per day. The estimated irradiance data are used to classify the sky conditions into clear, variable or cloudy. The results are compared with the outcomes of the same classification carried out with the irradiance measured in meteorological stations at two real PV sites. The occurrence of irradiance spikes in “broken cloud” conditions is identified and discussed. From the measured irradiance, the Alternating Current (AC) power injected into the grid at two PV sites is estimated by using a PV energy conversion model. The AC power errors resulting from the PV model with respect to on-site AC power measurements are shown and discussed.
The effect of prednisolone and ketotifen on the antigen‐induced bronchoconstriction and mediator release in rat isolated lungs (1985)

Using a new method for inducing IgE-mediated, systemic anaphylaxis in the rat both prednisolone and ketotifen had been shown previously to be effective in suppressing the bronchial anaphylaxis in vivo. In order to study the mode of action underlying their bronchoprotective effect, both agents were also tested on the antigen-induced bronchoconstriction in rat isolated lungs in relation to the mediator release in the lung-effluent. The presence of histamine, 5-hydroxytryptamine (5-HT) and SRS-A could be detected biologically in the lung-effluent during bronchoconstriction. Histamine and 5-HT were determined quantitatively by means of h.p.l.c. with fluorimetric detection, whereas SRS-A was determined using the guinea-pig ileum in a cascade set-up. Although both prednisolone and ketotifen inhibited the antigen-induced bronchoconstriction effectively, it appeared that only prednisolone suppressed the release of histamine, 5-HT and SRS-A in the lung-effluent significantly, whereas ketotifen had no effect. On account of these data it is suggested that the bronchoprotective effect of prednisolone is mainly based on inhibition of the release of the mediators involved, whereas the effect of ketotifen may be based on receptor antagonism.
A new preadipose cell line derived from newborn mouse calvaria can promote the proliferation of pluripotent hemopoietic stem cells in vitro (1982)

A clonal preadipose cell line MC3T3-G2/PA6, established from newborn mouse calvaria, responds to glucocorticoids and converts to adipose cells in a fashion similar to bone marrow preadipocytes. We investigated the effect of the cells on in vitro hemopoiesis of mouse bone marrow cells by cocultivation. When bone marrow cells were inoculated into confluent cultures of MC3T3-G2/PA6 cells (10(4)-10(6) cells/25-cm2 flask), the number of hemopoietic stem cells (CFU-S) significantly increased during 7-day cultivation in proportion to inoculum size. Under these conditions, active replication of CFU-S was maintained for several weeks until MC3T3-G2/PA6 cell layers detached from the substratum. This capacity of the MC3T3-G2/PA6 line was unique because other established cell lines, including the MTF preadipose line, failed to support CFU-S growth. When bone marrow cells were not allowed to contact the MC3T3-G2/PA6 cell layer, only a small number of CFU-S survived for 7 days. Moreover, MC3T3-G2/PA6 cell-conditioned medium did not show any growth-promoting activity for CFU-S. These results indicate that the MC3T3-G2/PA6 cell line has the ability to promote the proliferation of CFU-S through a short range cell-to-cell interaction by providing an in vitro microenvironment probably similar to that for in vivo hemopoiesis.
A computational method for assessing peptide‐ identification reliability in tandem mass spectrometry analysis with SEQUEST (2004)

High-throughput protein identification in mass spectrometry is predominantly achieved by first identifying tryptic peptides by a database search and then by combining the peptide hits for protein identification. One of the popular tools used for the database search is SEQUEST. Peptide identification is carried out by selecting SEQUEST hits above a specified threshold, the value of which is typically chosen empirically in an attempt to separate true identifications from false ones. These SEQUEST scores are not normalized with respect to the composition, length and other parameters of the peptides. Furthermore, there is no rigorous reliability estimate assigned to the protein identifications derived from these scores. Hence, the interpretation of SEQUEST hits generally requires human involvement, making it difficult to scale up the identification process for genome-scale applications. To overcome these limitations, we have developed a method, which combines a neural network and a statistical model, for normalizing SEQUEST scores, and also for providing a reliability estimate for each SEQUEST hit. This method improves the sensitivity and specificity of peptide identification compared to the standard filtering procedure used in the SEQUEST package, and provides a basis for estimating the reliability of protein identifications.
MR imaging of blood vessels using three-dimensional reconstruction: methodology. (1985)

Multisection, dual-echo magnetic resonance (MR) transaxial images of blood vessels contain both anatomic and qualitative information about flow. Even so, the images are produced as a series of two-dimensional tomographic sections from which full visualization of connected structures is difficult. A computer algorithm was developed that automatically detects flowing blood based on pixel intensity and calculated T2 and provides reconstructed views of vessels while analyzing and displaying flow characteristics. Images of abdominal vessels, aortic aneurysms, and the heart were encoded by flow and color to demonstrate depth. In addition, these data were reconstructed to derive a more accurate assessment of patency. With this technique, transaxial images can be used to analyze flow patterns, determine patent areas, and visualize all levels of vessels in a single image.
Stereoselective Organic Reactions in Water (2002)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereoselective Organic Reactions in WaterUlf M. LindströmView Author Information Bioorganic Chemistry, Center for Chemistry and Chemical Engineering, Lund University, P.O. Box 124, SE-221 00 Lund, Sweden Cite this: Chem. Rev. 2002, 102, 8, 2751–2772Publication Date (Web):June 19, 2002Publication History Received18 December 2001Published online19 June 2002Published inissue 1 August 2002https://pubs.acs.org/doi/10.1021/cr010122phttps://doi.org/10.1021/cr010122presearch-articleACS PublicationsCopyright © 2002 American Chemical SocietyRequest reuse permissionsArticle Views10059Altmetric-Citations1535LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Aldol reactions,Catalysts,Ligands,Organic reactions,Solvents Get e-Alerts
Intraindividual cognitive decline using a brief computerized cognitive screening test (2012)

Intraindividual decline in cognitive performance can be detected in otherwise healthy, community-dwelling, older persons, and this may deserve further study as a potential indicator of early Alzheimer's disease pathology.
Regulation of glutamine synthetase. XII. Electron microscopy of the enzyme from Escherichia coli (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRegulation of glutamine synthetase. XII. Electron microscopy of the enzyme from Escherichia coliR. C. Valentine, B. M. Shapiro, and E. R. StadtmanCite this: Biochemistry 1968, 7, 6, 2143–2152Publication Date (Print):June 1, 1968Publication History Published online1 May 2002Published inissue 1 June 1968https://pubs.acs.org/doi/10.1021/bi00846a017https://doi.org/10.1021/bi00846a017research-articleACS PublicationsRequest reuse permissionsArticle Views959Altmetric-Citations637LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Lactone, 24. Mitt.: „γ‐Lactonisierte” Neuroleptika ‐ Synthese, Stereochemie und Affinität am D<sub>2</sub>‐Rezeptor (1993)

Addition of piperidines 15a-d to methylene lactones 8,14a gives the "gamma-lactonized" diphenylbutylpiperidine-type neuroleptics 3a,b,d,4a-d. 8 can be produced by cyclization or--as well as 14--from the corresponding alpha-carboxylactone. 1H- and 13C-nmr data give evidence for the equatorial position of the aminomethyl group in all derivatives of 3 and 4 and bisequatorial-trans-configuration in 4a-d. 3H-spiroperidole displacement at the D2 receptor in rat brain by 3,4 and the "gamma-lactonized" butyrophenone neuroleptics 1,2a-c was investigated. Some compounds show moderate up to high (3b) activity.
Microtube Strip Heat Exchanger (1990)

Doty Scientific (DSI) believes their Microtube-Strip Heat Exchanger will contribute significantly to (a) the closed Brayton cycles being pursued at MIT, NASA, and elsewhere; (b) reverse Brayton cycle cryocoolers, currently being investigated by NASA for space missions, being applied to MRI superconducting magnets; and (c) high-efficiency cryogenic gas separation schemes for CO{sub 2} removal from exhaust stacks. The goal of this current study is to show the potential for substantial progress in high-effectiveness, low-cost, gas-to-gas heat exchangers for diverse applications at temperatures from below 100 K to above 1000 K. To date, the highest effectiveness measured is about 98%, and relative pressure drops below 0.1% with a specific conductance of about 45 W/kgK are reported. During the pre-award period DSI built and tested a 3-module heat exchanger bank using 103-tube microtube strip (MTS) modules. To add to their analytical capabilities, DSI has acquired computational fluid dynamics (CFD) software. This report describes the pre-award work and the status of the ten tasks of the current project, which are: analyze flow distribution and thermal stresses within individual modules; design a heat exchanger bank of ten modules with 400 microtube per module; obtain production quality tubestrip die and AISI 304 tubestrips; obtain production quality microtubing; construct revised MTS heat exchanger; construct dies and fixtures for prototype heat exchanger; construct 100 MTS modules; assemble 8-10 prototype MTS heat exchangers; test prototype MTS heat exchanger; and verify test through independent means. 7 refs., 9 figs. 1 tab. (CK)
Effects of adrenaline on human blood platelets (1967)

1. Adrenaline at concentrations too low to cause aggregation of human platelets potentiates the aggregation by adenosine diphosphate. Noradrenaline has the same effect but is less active than adrenaline; isopropylnoradrenaline is inactive or inhibitory.2. The potentiation of adenosine diphosphate by catecholamines is blocked by the adrenergic alpha-receptor antagonists phentolamine and dihydroergotamine but not by 2-halogenoethylamines or by adrenergic beta-receptor antagonists.3. Both the first and second phases of adenosine diphosphate aggregation are potentiated by catecholamines but the second phase more than the first.4. The release from the platelets of adenine nucleotides which is associated with the second phase of aggregation is also increased by adrenaline.
A 900-MHz bandwidth analog baseband circuit with 1-dB step and 30-dB gain dynamic range (2010)

A wide-bandwidth analog baseband circuit with digital gain control is implemented in a 65-nm CMOS process. The proposed circuit adopts a variable transconductance amplifier, which achieves constant bandwidth regardless of the gain settings. Bandwidth variation is less than ±1.2 % within the gain control range of 20 dB. The proposed analog baseband circuit has in-phase and quadrature-phase paths and draws 24.8 mA from a 1.2-V power supply. Measured results show that 1-dB step gain control with 0.25-dB differential nonlinearity (DNL) for 30-dB range and I/Q gain matching accuracy of 0.15 dB is achieved.
Size Effect on Navigation Using a Strapdown IMU (1979)

Abstract : Size effects in a strapdown IMU (Inertial Measurement Unit) are not always ignorable. They should be considered in the error budget for high accuracy inertial navigation. This report presents results of a study on size effects. It is found that while each individual accelerometer has only one type of size effect, an IMU has two in general, the 'mounting offset size effect' and the cluster size effect. General formulas for determining IMU size effect errors are developed in the report. Numerical examples, laboratory test results, and flight simulation results are given to demonstrate the size effects and to reveal their effect on navigation error. It is discussed that an optimum orientation for the accelerometer cluster can be chosen to minimize the navigation errors caused by size effects. It is also shown that, in principle, size effect of an IMU can be compensated using the angular rate information available from gyros. A size effect compensation concept is proposed with the associated computation algorithm given.
Los defectos naturales en la madera aserrada (2002)

Toda persona que use la madera, ya sea como material de construcción o con fines decorativos, estará pendiente de que las piezas con las que elaborará el producto, estén libres de defectos o aplicará las normas que limitan su presencia. Un defecto en la madera es cualquier irregularidad que reduzca su durabilidad, resistencia, valor estético o volumen utilizable. En este trabajo se profundiza en el conocimiento de estas irregularidades en la madera, en particular, las que ocurren de manera natural durante el crecimiento del árbol, comentando la forma como se presentan, los tipos que existen, así como la manera de medirlas.
Utilization of Electrochemical Impedance Techniques to Estimate Corrosion Damage of Steel Infrastructures (1992)

Infrastructures such as bridges, highways, pipelines and harbor piers sometimes suffer from corrosion damage during their service life. To diagnose deterioration of infrastructures and secure effective maintenance, in-situ corrosion monitoring methods based on electrochemical impedance techniques have been developed. This paper reports three examples of new corrosion monitoring sensors: 1) a sensor for detecting corrosion of marine steel structures in seawater, 2) a sensor for detecting corrosion of reinforcing bars in concrete, and 3) a sensor for detecting coating deterioration of painted steel structures in the atmosphere. The effectiveness of these sensors has been verified by experiments both in the laboratory and in the field.
Microstructure and electrical properties of Sb nanocrystals formed in thin, thermally grown SiO2 layers by low-energy ion implantation (1999)

We have formed Sb nanocrystals in thin, thermally grown SiO2 layers using low-energy ion implantation which was followed by thermal annealing. These Sb nanocrystals showed good uniformity with respect to size and position. Both the narrow as-implanted profile and the compressive strain that exists near the SiO2/Si interface are considered to contribute to the uniformity. We found that it was possible to control the size of the Sb nanocrystal by changing the dose of the implanted Sb. The I–V characteristics of the diodes which had Sb nanocrystals with an average diameter of 3.3 nm showed good reproducibility. Moreover, these diodes showed a Coulomb blockade region around 0 V and a Coulomb staircase at 4.2 K. Identical I–V characteristics were obtained for all the samples measured, indicating an excellent reproducibility. Almost the same Coulomb blockade region as that at 4.2 K was observed up to a temperature as high as 100 K even for a diode which had larger Sb nanocrystals (with an average diameter of 5.6 nm). The technique introduced here offers the possibility of developing practical Si-based single-electron devices.
Interaction of Vanadate with the Cloned Beta Cell KATP Channel (1999)

Vanadate is used as a tool to trap magnesium nucleotides in the catalytic site of ATPases. However, it has also been reported to activate ATP-sensitive potassium (K(ATP)) channels in the absence of nucleotides. K(ATP) channels comprise Kir6.2 and sulfonylurea receptor subunits (SUR1 in pancreatic beta cells, SUR2A in cardiac and skeletal muscle, and SUR2B in smooth muscle). We explored the effect of vanadate (2 mM), in the absence and presence of magnesium nucleotides, on different types of cloned K(ATP) channels expressed in Xenopus oocytes. Currents were recorded from inside-out patches. Vanadate inhibited Kir6.2/SUR1 currents by approximately 50% but rapidly activated Kir6.2/SUR2A ( approximately 4-fold) and Kir6. 2/SUR2B ( approximately 2-fold) currents. Mutations in SUR that abolish channel activation by magnesium nucleotides did not prevent the effects of vanadate. Studies with chimeric SUR indicate that the first six transmembrane domains account for the difference in both the kinetics and the vanadate response of Kir6.2/SUR1 and Kir6. 2/SUR2A. Boiling the vanadate solution, which removes the decavanadate polymers, largely abolished both stimulatory and inhibitory actions of vanadate. Our results demonstrate that decavanadate modulates K(ATP) channel activity via the SUR subunit, that this modulation varies with the type of SUR, that it differs from that produced by magnesium nucleotides, and that it involves transmembrane domains 1-6 of SUR.