gebhart/patrepeval huggingface dataset:
Out‐of‐body experience and autoscopy of neurological origin (2004)

During an out-of-body experience (OBE), the experient seems to be awake and to see his body and the world from a location outside the physical body. A closely related experience is autoscopy (AS), which is characterized by the experience of seeing one's body in extrapersonal space. Yet, despite great public interest and many case studies, systematic neurological studies of OBE and AS are extremely rare and, to date, no testable neuroscientific theory exists. The present study describes phenomenological, neuropsychological and neuroimaging correlates of OBE and AS in six neurological patients. We provide neurological evidence that both experiences share important central mechanisms. We show that OBE and AS are frequently associated with pathological sensations of position, movement and perceived completeness of one's own body. These include vestibular sensations (such as floating, flying, elevation and rotation), visual body-part illusions (such as the illusory shortening, transformation or movement of an extremity) and the experience of seeing one's body only partially during an OBE or AS. We also find that the patient's body position prior to the experience influences OBE and AS. Finally, in five patients, brain damage or brain dysfunction is localized to the temporo-parietal junction (TPJ). These results suggest that the complex experiences of OBE and AS represent paroxysmal disorders of body perception and cognition (or body schema). The processes of body perception and cognition, and the unconscious creation of central representation(s) of one's own body based on proprioceptive, tactile, visual and vestibular information-as well as their integration with sensory information of extrapersonal space-is a prerequisite for rapid and effective action with our surroundings. Based on our findings, we speculate that ambiguous input from these different sensory systems is an important mechanism of OBE and AS, and thus the intriguing experience of seeing one's body in a position that does not coincide with its felt position. We suggest that OBE and AS are related to a failure to integrate proprioceptive, tactile and visual information with respect to one's own body (disintegration in personal space) and by a vestibular dysfunction leading to an additional disintegration between personal (vestibular) space and extrapersonal (visual) space. We argue that both disintegrations (personal; personal-extrapersonal) are necessary for the occurrence of OBE and AS, and that they are due to a paroxysmal cerebral dysfunction of the TPJ in a state of partially and briefly impaired consciousness.
Consumption of gluten with gluten-degrading enzyme by celiac patients: A pilot-study (2013)

AN-PEP appears to be well tolerated. However, the primary endpoint was not met due to lack of clinical deterioration upon placebo, impeding an effect of AN-PEP.
Gracilis myocutaneous and muscle flaps. (1980)

Surgical techniques for the elevation of gracilis myocutaneous and muscle flaps are outlined and a versatile range of clinical applications discussed. Even greater future diversity is foreseen for this donor unit.
MINT: a Molecular INTeraction database (2001)

Protein interaction databases represent unique tools to store, in a computer readable form, the protein interaction information disseminated in the scientific literature. Well organized and easily accessible databases permit the easy retrieval and analysis of large interaction data sets. Here we present MINT, a database (http://cbm.bio.uniroma2.it/mint/index.html) designed to store data on functional interactions between proteins. Beyond cataloguing binary complexes, MINT was conceived to store other types of functional interactions, including enzymatic modifications of one of the partners. Release 1.0 of MINT focuses on experimentally verified protein-protein interactions. Both direct and indirect relationships are considered. Furthermore, MINT aims at being exhaustive in the description of the interaction and, whenever available, information about kinetic and binding constants and about the domains participating in the interaction is included in the entry. MINT consists of entries extracted from the scientific literature by expert curators assisted by 'MINT Assistant', a software that targets abstracts containing interaction information and presents them to the curator in a user-friendly format. The interaction data can be easily extracted and viewed graphically through 'MINT Viewer'. Presently MINT contains 4568 interactions, 782 of which are indirect or genetic interactions.
On the feasibility and suitability of MR and ER based actuators in human friendly manipulators (2009)

For several decades now, the robotics industry has postulated the emergence of a new breed of manipulators capable of safely interacting with humans. The integration of robots into human environments has always possessed a unique set of challenges. The primary concern has always been for the safety of the human coworkers. Insuring their safety has led to the desire to design manipulators with intrinsic safety characteristics. Specifically, it is noted that modern `human-safe' manipulators are successful if they have minimized both their weight and reflected actuator inertia. The leading research accomplishing this relies on complex actuation systems. Such systems commonly suffer from degraded performance and high cost of development. Magneto- and electro-rheological fluids are a class of smart-materials that can instantaneously, and reversibly alter their rheological properties under the influence of an applied field. Devices developed with such fluids are known to possess superior torque-to-inertia characteristics over conventional servo systems. Moreover, their simple mechanical construction suggests that manipulators using such devices could be developed at a lower cost. In this paper, we will discuss the potential benefits rheological fluids can bring to the field of human friendly manipulators.
Temporal Artery Biopsy of Giant Cell Arteritis (2001)

Giant cell arteritis is an idiopathic inflammatory disease affecting muscular and elastic arteries. Most patients are elderly, and there is a female predominance. The disease may affect virtually any arterial bed, but there is predisposition for the cranial arteries. The temporal artery is usually biopsied, because of its superficial nature, and high frequency of involvement, often with a palable mass. The diagnostic histologic feature is a macrophage infiltrate of the internal elastic lamina with destruction of the elastica. Lymphocytes and areas of necrosis may be seen. A case illustrating a subtle case of giant cell arteritis of the temporal artery is presented. The differential diagnosis, including other forms of arteritis that may affect the temproal artery, is discussed.
Is nuclear expression of Y box-binding protein-1 a new prognostic factor in ovarian serous adenocarcinoma? (1999)

The expression of YB- 1 protein in the nucleus may be considered a useful prognostic marker and also may reflect the sensitivity of ovarian serous adenocarcinoma to chemotherapy.
Processing and Properties of Liquid Rubbers (1973)

Abstract Difficulties of compounding liquid rubbers are discussed and detailed descriptions are given of mixers for the adequate continuous dispersion of carbon black and of light-weight injection molding machines suitable for the pastes which result; some of the problems of injection molding are outlined and suggested solutions given. The reinforcement of liquid rubbers with textile fibers is discussed and suggestions proposed for the layout of a factory suitable for the processing of liquid rubbers.
Human lymphoblastoid cells with acquired resistance to C2-desamino-C2-methyl-N10-propargyl-5,8-dideazafolic acid: a novel folate-based thymidylate synthase inhibitor. (1992)

We describe the characterization of human lymphoblastoid cell lines with acquired resistance (greater than 20,000-fold) to a novel folate-based thymidylate synthase (TS) (EC 2.1.1.45) inhibitor, C2-desamino-C2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI198583). This acquired resistance was associated with a 64-fold amplification of the TS gene, a similar elevation in the corresponding mRNA, and an approximately 200-fold increase in both TS activity and TS protein. This amplification was maintained when the cells were grown in the absence of the selective agent, ICI198583, for 340 generations. TS isolated from one of the resistant cell lines, W1-L2:C1, displayed inhibition kinetic parameters similar to those of TS isolated from the parent W1-L2 cell line. It thus appears unlikely that resistance is due to an altered TS enzyme having a lower affinity for ICI198583. The resistant cell line, W1-L2:C1, was cross-resistant to other folate-based TS inhibitors but was as sensitive as the parent cell line, W1-L2, to 5-fluorodeoxyuridine. The W1-L2:C1 cell line was collaterally sensitive to the classical dihydrofolate reductase (EC 1.5.1.3) inhibitor methotrexate as well as to the lipophilic dihydrofolate reductase inhibitors metoprine and 2,4-diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyl]quinazolin e glucuronic acid salt (also called trimetrexate). When the W1-L2 and W1-L2:C1 cell lines were exposed to 1 microM ICI198583 for 24 h they accumulated the same concentration of total cellular ICI198583 polyglutamates despite the fact that the latter cell line accumulated a 300-fold greater concentration of ICI198583 monoglutamate. As polyglutamates, the tetra- and pentaglutamate forms predominated in the W1-L2 cell line, whereas the diglutamate form predominated in the W1-L2:C1 cell line, with few higher polyglutamates being detected. The lack of tri- and higher polyglutamates of ICI198583 (i.e., the more active species) in the W1-L2:C1 cell line may also contribute to the observed resistance. These findings may have important implications in light of the rapid onset of resistance to antifolates in the clinic.
Giving monoclonal antibodies to healthy volunteers in phase 1 trials: is it safe? (2013)

Many monoclonal antibodies (MAbs) have been studied in healthy volunteers in phase 1, but few data have been published on the safety of that practice. We aimed to review the available data, and thereby to estimate the risks of participation in phase 1trials of MAbs. We searched PubMed, the ClinicalTrials.gov database and Google, using the search terms 'monoclonal antibody', 'phase 1' and 'healthy volunteers'. We identified 70 completed trials of MAbs in healthy volunteers, but the published data were too sparse to allow confident assessment of the risks of MAbs in healthy volunteers. Our best estimate of risk of a life-threatening adverse event was between 1: 425 and 1: 1700 volunteer-trials, but all such events occurred in a single trial (of TGN1412). In a phase 1trial of a small molecule, the risk of death or a life-threatening adverse event appears to be 1: 100,000-1,000,000 volunteer-trials, which is similar to the risk of many ordinary daily activities. Most people would consider that level of risk to be 'minimal' or 'negligible' and, therefore, acceptable. On that basis, the safety record of MAbs in healthy volunteers has been ruined by the TGN1412 disaster. However, that experience is unlikely to be repeated, because of improvements in governance and practice of phase 1trials. If the experience of TGN1412 is disregarded, it seems reasonable to continue using healthy volunteers in phase 1trials of MAbs, provided that there are scientific and medical reasons to conclude that the risk is truly minimal.
Grid-Connected Integrated Battery Chargers in Vehicle Applications: Review and New Solution (2012)

For vehicles using grid power to charge the battery, traction circuit components are not engaged during the charging time, so there is a possibility to use them in the charger circuit to have an onboard integrated charger. The battery charger can be galvanically isolated or nonisolated from the grid. Different examples of isolated or nonisolated integrated chargers are reviewed and explained. Moreover, a novel isolated-high-power three-phase battery charger based on a split-phase permanent-magnet motor and its winding configuration is presented in this paper. The proposed charger is a bidirectional high-power charger with a unity power factor operation capability that has high efficiency.
The common Arg <sup>972</sup> polymorphism in insulin receptor substrate‐1 causes apoptosis of human pancreatic islets (2000)

Molecular scanning of human IRS-1 gene revealed a common polymorphism causing Gly-->Arg972 change. Diabetic and pre-diabetic carriers of Arg972 IRS-1 are characterized by low fasting levels of insulin and C-peptide. To investigate directly whether the Arg 972 IRS-1 affects human islet cells survival, we took advantage of the unique opportunity to analyze pancreatic islets isolated from three donors heterozygous for the Arg972 and six donors carrying wild-type IRS-1. Islets from carriers of Arg972 IRS-1 showed a two-fold increase in the number of apoptotic cells as compared with wild-type. IRS-1-associated PI3-kinase activity was decreased in islets from carriers of Arg972 IRS-1. Same results were reproduced in RIN rat b-cell lines stably expressing wild-type IRS-1 or Arg972 IRS-1. Using these cells, we characterized the downstream pathway by which Arg972 IRS-1 impairs b-cell survival. RIN-Arg972 cells exhibited a marked impairment in the sequential activation of PI3-kinase, Akt, and BAD as compared with RI N-WT. Impaired BAD phosphorylation resulted in increased binding to Bcl-XL instead of 14-3-3 protein, thus sequestering the Bcl-XL antiapoptotic protein to promote survival. Both caspase-9 and caspase-3 activities were increased in RIN-Arg972 cells. The results show that the common Arg972 polymorphism in IRS-1 impairs human b-cell survival and causes resistance to antiapoptotic effects of insulin by affecting the PI3-kinase/Akt survival pathway. These findings establish an important role for the insulin signaling in human b-cell survival and suggest that genetic defects in early steps of insulin signaling may contribute to b-cell failure.
Maternity Policies and Working Women. (1984)

PrefaceI. Past Times II. The Last Fat Year (1930) III. Lean Years (1931-1932) IV. The Leanest Year (1933) V. New Deal Baseball (1934-1935) VI. Toward Recovery (1936-1937) VII. Pathos and Progress (1938-1939) VIII. Baseball Lives IX. Shadowball X. Recovery and War (1940-1941)Postscript Notes Selected Bibliorgraphy Index
Object spatial recognition for service robots: Where is the front? (2011)

Exactly same objects produce dramatically different images depending on their poses to the camera and result in great ambiguity for spatial recognition. Different poses of same objects also lead to different orientations in the use of intrinsic system. Our current study is focusing on this issue and can be divided into three phases. First, we propose an object pose-estimation model which is capable of recognizing unseen views. We achieve this goal by building a discrete key-pose structure parameterized by an azimuth and using PHOG [20] descriptor to measure the shape correspondence between two images. A large number of instances are learned at the training stage through semi-supervised. Then, we show experimental results on our own dataset. Second, according to the analyzed criteria in the use of intrinsic system, we recognize the frontal orientation of an intrinsic geometry object combining with pose-estimation results (e.g., a LCD screen). Finally, we summarize our integrated model which is able to classify object category, estimate object pose, distinguish intrinsic spatial relations between reference and target objects and locate the target under users' instructions.
Relevant Aspects of Physiology in Chronic Pancreatitis (1992)

Specific points of physiology which are relevant for the understanding and management of chronic pancreatitis are focussed on. First, the regulatory factors of exocrine pancreatic secretion are described, discussing the role of the cholinergic system and of the classical gut hormones cholecystokinin and secretin. The association of upper gastrointestinal dysfunctions with a disturbed exocrine pancreatic response is also dealt with. Lastly, these changes are related to clinical consequences such as maldigestion or malabsorption.
URETERAL TISSUE EXPANSION FOR BLADDER AUGMENTATION: A LONG-TERM PROSPECTIVE CONTROLLED TRIAL IN A PORCINE MODEL (1998)

Serial cystograms in pigs after ureteral augmentation suggest that the tissue does not contract with time. Animals that underwent ureteral augmentation had significantly greater bladder capacity than controls. Random bladder residual urine volume remained low throughout the study period. Ureteral tissue expansion for bladder augmentation appears to be feasible and durable in this animal model. In addition, it may be protective against the deleterious effects associated with small capacity bladders.
Hot service deployment in an ad hoc grid environment (2004)

In this paper, we present a solution to the probl of dynamically deploying grid service factories onto computing nodes running an implentation of the Open Grid Services Infrastructure (OGSI). By providing a non-intrusive Hot Deployment Service (HDS), we extend the service-oriented grid computing paradigm, as it is defined by the Open Grid Services Architecture (OGSA), to provide a more dynamic ad hoc grid environment. Service-oriented grid middleware utilizing the HDS enables organizations or interorganizational communities to form an ad hoc grid to harness unused and scattered resources of an existing IT-infrastructure. The availability of the HDS also improves the capabilities to manage existing grid systs based on the Globus Toolkit 3, which is a vital requirent for the adoption of service-oriented grid systs in production environments.
Immonium ion based synthetic methodology: a novel method for the N-methylation of dipeptides and amino acid derivatives via retro aza Diels-Alder reactions (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTImmonium ion based synthetic methodology: a novel method for the N-methylation of dipeptides and amino acid derivatives via retro aza Diels-Alder reactionsPaul A. Grieco and Ali BahsasCite this: J. Org. Chem. 1987, 52, 26, 5746–5749Publication Date (Print):December 1, 1987Publication History Published online1 May 2002Published inissue 1 December 1987https://pubs.acs.org/doi/10.1021/jo00235a021https://doi.org/10.1021/jo00235a021research-articleACS PublicationsRequest reuse permissionsArticle Views1787Altmetric-Citations90LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The evolving role of lyophilized plasma in remote damage control resuscitation in the <scp>F</scp>rench <scp>A</scp>rmed <scp>F</scp>orces <scp>H</scp>ealth <scp>S</scp>ervice (2013)

Freeze-dried plasma was developed by the US Army for the resuscitation of combat casualties during World War II. The French Military Blood Institute began producing French lyophilized plasma (FLYP) in 1949, in accordance with French blood product guidelines. Since 2010, a photochemical pathogen inactivation process has been implemented to reduce the remaining transfusion-related infectious risk. All quality controls for this procedure verify that the hemostatic properties of FLYP are conserved. FLYP is compatible with all blood types, can be stored at room temperature for 2 years, and its reconstitution requires less than 6 minutes. As a result, FLYP allows quick delivery of all the coagulation proteins and the application of a 1:1 ratio of FLYP and red blood cells in the context of a massive transfusion. Hemovigilance data collected in France since 1994 have included FLYP. Results indicate no reporting of infection related to the use of FLYP. Clinical monitoring with a focus on hemostasis was implemented in 2002 and expanded in 2010. The data, obtained from overseas operations, confirmed the indications, the safety and the clinical efficacy of FLYP. Further research is needed to determine specific indications for FLYP in the therapeutic management of civilian patients with severe hemorrhage.
AnyControl -- IoT Based Home Appliances Monitoring and Controlling (2015)

Technologies for Internet of Things (IoT) such as sensor, network and data processing are advancing rapidly. Thanks to the evolution, many potential applications have been developed in the fields of analysis and automation. In this paper, a platform was designed to connect sensor data with users daily life. As an application of it, AnyControl - a home appliances monitoring and controlling system was implemented. Although home appliances are becoming more intelligent day by day. Not only are manufacturers promoting new smart appliances, there are also many smartphone oriented remote controller products. However current products always have platform compatibility problems, additionally, user interaction in such systems are becoming more and more complex. This work proposes an approach to enhance old appliances and the controlling experience through an IoT based Home Appliance Controlling System. With sensors the appliances can be controlled environment condition trigger. The sensor data are processed by single-board computer and delivered to mobile applications through wireless connection. The results of implementation and experimentation has shown the proposed system and platform can provide more IoT application possibilities daily life.
Robust planar textile antenna for wireless body LANs operating in 2.45 GHz ISM band (2006)

A single-feed rectangular-ring textile antenna is proposed for wireless body area networks operating in the 2.45 GHz ISM band. The conductive parts of the planar antenna consist of FlecTron®, whereas fleece fabric is used as non-conductive antenna substrate. This results in a highly efficient, flexible and wearable antenna to be integrated in garments. The robustness of the antenna characteristics with respect to bending is proven.
Toward a unified approach to dose–response modeling in ecotoxicology (2010)

This study reviews dose-response models that are used in ecotoxicology. The focus lies on clarification of differences and similarities between models, and as a side effect, their different guises in ecotoxicology are unravelled. A look at frequently used dose-response models reveals major discrepancies, among other things in naming conventions. Therefore, there is a need for a unified view on dose-response modeling in order to improve the understanding of it and to facilitate communication and comparison of findings across studies, thus realizing its full potential. This study attempts to establish a general framework that encompasses most dose-response models that are of interest to ecotoxicologists in practice. The framework includes commonly used models such as the log-logistic and Weibull models, but also features entire suites of models as found in various guidance documents. An outline on how the proposed framework can be implemented in statistical software systems is also provided.