gebhart/patrepeval huggingface dataset:
The fluid-phase assembly of the membrane attack complex of complement (1986)

The dynamics and protein stoichiometry of the fluid-phase assembly of the membrane attack complex of complement were characterized by using light-scattering intensity measurements. The assembly proceeded in an ordered manner with generation of stable and highly reproducible intermediates. In the absence of phospholipid or C8, mixtures of C5b-6 and C7 self-associated to fluid phase-C5b-7 which had a weight-average molecular weight of (4.1 +/- 0.2) X 10(6). This corresponded to an average of nine C5b-7 complexes per particle. The particles appeared heterodisperse on sucrose gradients with S20,W values ranging from 21 to 39 S. Addition of C8 and C9 caused no further aggregation or disassembly of the particles. When excess C8 was added to the aggregated C5b-7, the ratio of C8 incorporated per C5b-7 moiety was 0.98 +/- 0.03. At saturating levels of C9, the C9/C5b-8 ratio in the particles was 7.2 +/- 0.6. Incorporation of C8 caused a small increase in the Z-averaged particle diffusion coefficient [(9.9-10.3) X 10(-8) cm2/s], indicating that it added in a manner that "filled in the gaps" in the C5b-7 particles. C9 caused only small decreases in the particle diffusion coefficient and substantially decreased the f/fmin ratio. The time course for C9 incorporation into fluid phase-C5b-8 indicated an initial rapid phase followed by a slow phase. The rapid phase corresponded to the incorporation of about one C9 for every two C5b-8 complexes. This suggested that one C9 binding site was accessible on about half of the C5b-8 complexes. This may imply that only about half of the C5b-8 complexes were capable of C9 polymerization so that the ratio of C9 incorporated per functional C5b-8 was (14 +/- 2)/1. The initial velocity of the slow phase of C9 addition gave an activation energy of 37 kcal/mol. The activation energy for C5b-8-independent polymerization of C9 had a similar value of 41 kcal/mol. Light-scattering intensity measurements seemed to be a highly reliable method for quantitative characterization of the fluid-phase assembly.
Plasma treatment of PET and acrylic coating surfaces - I. In-situ XPS measurements (2000)

Abstract The surface modification of poly(ethylene terephthalate) (PET) and UV-cured tripropyleneglycol diacrylate (acrylic) films induced by remote N2 and Ar microwave plasmas (2.45 GHz) was compared by in-situ XPS measurements. Both N2 and Ar plasma treatments led to destruction of the initial oxygen-containing groups. The destruction of ester groups was much faster for the acrylic than for the PET film, and the destruction of ether groups was much faster than that of ester groups within the acrylic film. Among the plasma gases, N2 was more effective than Ar in the case of PET, but their difference was negligible in the case of the acrylic film. The higher stability of the PET surface was attributed to the presence of a rigid aromatic backbone, which protected the ester groups from plasma UV irradiation and stabilized the free radicals. The lower stability of the acrylic film was associated with the presence of weak ether groups. New functional groups were created, attributed to carbonyl in the case of Ar, and carbonyl/amide and amine in the case of N2 plasma treatments. The formation of these new functional groups was very small compared with the loss of ether and ester groups, suggesting that the destruction of these oxygen-containing groups proceeded mainly through elimination of the entire groups. Keywords: PLASMA TREATMENTACRYLIC COATINGIN-SITU XPS
A survey on OFDM PAPR reduction techniques for 60 GHz wireless CMOS radio (2007)

Multi-giga-bit-per-second 60 GHz transceivers are being developed and implemented on CMOS. OFDM is being considered as the modulation scheme. High peak-to-average power ratio (PAPR) is a major problem for OFDM. This paper reviews and discusses the advantages and limitations of several important PAPR reduction techniques such as coding, partial transmit sequence, clipping, selective mapping, tone reservation, tone injection, and active constellation extension. It concludes that clipping and partial transmit sequence are more practical than other techniques for implementation of multi-giga-bit-per-second 60 GHz wireless communication systems.
Individual Differences in AMY1 Gene Copy Number, Salivary α-Amylase Levels, and the Perception of Oral Starch (2010)

By linking genetic variation and its consequent salivary enzymatic differences to the perceptual sequellae of these variations, we show that AMY1 copy number relates to salivary amylase concentration and enzymatic activity level, which, in turn, account for individual variation in the oral perception of starch viscosity. The profound individual differences in salivary amylase levels and salivary activity may contribute significantly to individual differences in dietary starch intake and, consequently, to overall nutritional status.
Rewritable Near-Field Optical Recording on Photochromic Thin Films (1996)

Rewritable photon-mode near-field optical recording by the use of an ultra-small light source (diameter ∼100 nm) was performed. Bis(2-methylbenzo[b]thiophen-3-yl)perfluorocyclopentene dispersed in polystyrene and amorphous bis(2,4-dimethyl-5-phenylthiophen-3-yl)perfluorocyclopentene films were used as the recording media. Marks 100 nm in width were recorded on the media by irradiation with 529 nm light, and erased by irradiation with UV light ( 300 nm<λ<400 nm).
Sluicing and Focus Movement in Wh-in-situ Languages (2006)

For wh-moving languages like English, the elliptical part is an IP, and the wh-phrase is immune from ellipsis since it wh-moves given a PF deletion account (cf. Lasnik 1999, Merchant 2001, to name just a few). However, a proper analysis of sluicing( -like) structures is still under debate for wh-irrsitu languages like Mandarin Chinese (MC) because the wh-phrases in these languages generally do not undergo overt wh-movement; thus the configuration that feeds IP deletion is apparently underivable. Based on MC data, the goal of this paper is to argue that overt movement of wh-phrases always takes place prior to IP ellipsis in sluicing, either to satisfy a [ +wh] feature in wh-moving languages like English or to meet a [+focus] feature requirement in wh-in-situ languages like MC. The paper starts with a description of MC sluicing data and, subsequently, our analysis is provided and compared with other approaches now on the market. Section 3 gives detailed arguments for favoring overt movement and a deletion operation as in our proposal. Section 4 discusses the occurrence of shi 'be' in MC with respect to argumentadjunct asymmetry; Section 5 concludes the paper.
Tough adhesives for diverse wet surfaces (2017)

Adhesion to wet and dynamic surfaces, including biological tissues, is important in many fields but has proven to be extremely challenging. Existing adhesives are cytotoxic, adhere weakly to tissues, or cannot be used in wet environments. We report a bioinspired design for adhesives consisting of two layers: an adhesive surface and a dissipative matrix. The former adheres to the substrate by electrostatic interactions, covalent bonds, and physical interpenetration. The latter amplifies energy dissipation through hysteresis. The two layers synergistically lead to higher adhesion energies on wet surfaces as compared with those of existing adhesives. Adhesion occurs within minutes, independent of blood exposure and compatible with in vivo dynamic movements. This family of adhesives may be useful in many areas of application, including tissue adhesives, wound dressings, and tissue repair.
Application of electrochemically produced and oxidized poly(3,4‐ethylenedioxythiophene) as anticorrosive additive for paints: Influence of the doping level (2006)

Abstract This work investigates the resistance against marine corrosion of an epoxy‐based coating modified by the addition of electrochemically produced and oxidized poly(3,4‐ethylenedioxythiophene) (PEDOT). For this purpose, electrodeposition of PEDOT was performed on steel electrodes by electrochemical polymerization of 3,4‐ethylenedioxythiophene. The doping level of the resulting material was increased by chronoamperometry and chronopotentiometry (CP), three different oxidation degrees being achieved. The electrochemical and electrical properties of such three samples, which were used as anticorrosive additives, were examined. Furthermore, the physical properties of the coating before and after addition of the conducting polymers were characterized using FTIR, thermal analyses, and mechanical properties evaluations. Accelerated corrosion tests indicated that the polymer with the highest amount of positive charge per monomeric unit, which was achieved by CP, enhances considerably the anticorrosive protection imparted by the coating. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 102: 1592–1599, 2006
Geometrical Representation of the Schrödinger Equation for Solving Maser Problems (1957)

A simple, rigorous geometrical representation for the Schrödinger equation is developed to describe the behavior of an ensemble of two quantum-level, noninteracting systems which are under the influence of a perturbation. In this case the Schrödinger equation may be written, after a suitable transformation, in the form of the real three-dimensional vector equation dr/dt=ω×r, where the components of the vector r uniquely determine ψ of a given system and the components of ω represent the perturbation. When magnetic interaction with a spin ½ system is under consideration, ``r'' space reduces to physical space. By analogy the techniques developed for analyzing the magnetic resonance precession model can be adapted for use in any two-level problems. The quantum-mechanical behavior of the state of a system under various different conditions is easily visualized by simply observing how r varies under the action of different types of ω. Such a picture can be used to advantage in analyzing various MASER-type devices such as amplifiers and oscillators. In the two illustrative examples given (the beam-type MASER and radiation damping) the application of the picture in determining the effect of the perturbing field on the molecules is shown and its interpretation for use in the complex Maxwell's equations to determine the reaction of the molecules back on the field is given.
Replantation of teeth and antibiotic treatment (1986)

Abstract Administration of antibiotics is usually recommended when a traumatically avulsed tooth is replanted, in order to prevent bacterial contamination. In the present study, permanent lateral incisors of monkeys were extracted, allowed to dry for 1 h and then replanted. Some teeth had their pulp chambers opened labially and left open for 3 wk after replantation. The monkeys were treated with antibiotics (i.m.) either at the lime of replantation or 3 wk after replantation. In some monkeys, antibiotics were placed in the pulpal cavity. Comparisons were made of the effect of endodontic treatment on periodontal healing and root resorption. The monkeys were killed 8 wk after replantation. It was found that after systemic antibiotic treatment at the time of replantation there was no inflammatory root resorption. Also, endodontic treatment at the time of replantation prevented inflammatory root resorption. When systemic antibiotic treatment was instituted 3 wk after (he replantation, there was no reduction of the inflammatory root resorption as compared with teeth without antibiotic treatment. Application of antibiotics in the pulp 3 wk after replantation almost completely eliminated the inflammatory resorption. In all the treatment groups where administration of antibiotics or endodontic treatment had prevented, reduced or eliminated inflammatory root resorption, 30–45% of the root surface area was ankylotic 8 wk after replantation.
The magnetron beam switching tube. Its operation and circuit design criteria (1955)

The properties of a magnetron type of beam switching tube (a tube operated with crossed electric and magnetic fields) and its operation as a switching component are described. The tube is called the magnetron beam switching tube (abbreviated MBS tube). Because of the electron beam-forming property of crossed fields, a tube with 10 anode segments individually connected through proper impedances may operate with 10 stable beam positions at each of which the electron beam will strike only one of the segments; or it will operate in an astable state, in which the electron beam sweeps from one segment to another successively. Astable operation of the tube is the result of a relaxation oscillation. By combining the stable and astable operations, the tube may be very useful in switching circuits. A description of electron paths in the tube is given to help one acquire an insight into the tube operation. A method is given for designing MBS tube circuits. The stability of the stable states and the consistency of the switching operation are discussed. Comparisons are made between the MBS tubes and other counting devices.
Synthesis and anti-inflammatory activity of certain new N,N'-oxamides. (1980)

Some new amides of substituted oxamic acid which embody different moieties of the anti-inflammatory drugs were prepared through two routes of synthesis. The physico-chemical properties as well as the anti-inflammatory activity of these compounds were determined. Preliminary pharmacological testing revealed the superiority of most of the screened compounds as anti-inflammatory agents with relatively low toxicity as compared with acetylsalicylic acid. Correlation between structure and biological activity was suggested.
Type II Metacaspases Atmc4 and Atmc9 of Arabidopsis thaliana Cleave Substrates after Arginine and Lysine (2004)

Nine potential caspase counterparts, designated metacaspases, were identified in the Arabidopsis thaliana genome. Sequence analysis revealed two types of metacaspases, one with (type I) and one without (type II) a proline- or glutamine-rich N-terminal extension, possibly representing a prodomain. Production of recombinant Arabidopsis type II metacaspases in Escherichia coli resulted in cysteine-dependent autocatalytic processing of the proform into large and small subunits, in analogy to animal caspases. A detailed biochemical characterization with a broad range of synthetic oligopeptides and several protease inhibitors of purified recombinant proteins of both metacaspase 4 and 9 showed that both metacaspases are arginine/lysine-specific cysteine proteases and did not cleave caspase-specific synthetic substrates. These findings suggest that type II metacaspases are not directly responsible for earlier reported caspase-like activities in plants.
Fast probabilistic analysis of sequence function using scoring matrices (2000)

The techniques described above are implemented in a software package called EMATRIX. This package is available from the authors for free academic use or for licensed commercial use. The EMATRIX set of programs is also available on the Internet at http://motif.stanford.edu/ematrix.
A unified turbo/Viterbi channel decoder for 3GPP mobile wireless in 0.18-μm CMOS (2002)

A channel decoder chip compliant with the 3GPP mobile wireless standard is described. It supports both data and voice calls simultaneously in a unified turbo/Viterbi decoder architecture. For voice services, the decoder can process over 128 voice channels encoded with rate 1/2 or 1/3, constraint length 9 convolutional codes. For data services, the turbo decoder is capable of processing any mix of rate 1/3, constraint length 4 turbo encoded data streams with an aggregate data rate of up to 2.5 Mb/s with 10 iterations per block (or 4.1 Mb/s with six iterations). The turbo decoder uses the logMAP algorithm with a programmable logsum correction table. It features an interleaver address processor that computes the 3GPP interleaver addresses for all block sizes enabling it to quickly switch context to support different data services for several users. The decoder also contains the 3GPP first channel de-interleaving function and a post-decoder bit error rate estimation unit. The chip is fabricated in a 0.18-/spl mu/m six-layer metal CMOS technology, has an active area of 9 mm/sup 2/, and has a peak clock frequency of 110.8 MHz at 1.8 V (nominal). The power consumption is 306 mW when turbo decoding a 2-Mb/s data stream with ten iterations per block and eight voice calls simultaneously.
Pitfalls in the Conception, Manipulation, and Measurement of Visual Accommodation (1990)

Reports of applied research in visual accommodation frequently contain points of confusion, suggesting that there may be some widespread misunderstanding regarding the nature of accommodation, the complexities involved in its measurement, and the multiple meanings inherent in its terminology. The present paper reviews several of these problem areas. Included are discussions of the effect of refractive error on accommodation assessment; the dangers involved in assuming equivalence among physiological, refractive power, and conjugate distance changes; and multiple meanings in the conception of resting accommodation. A variety of manipulation and measurement problems also are reviewed, including the specification of accommodative target distance, the use of lenses, and the correction of refractive error. The review concludes with recommendations regarding conceptions and procedures useful in avoiding the difficulties described.
Functional Importance of Synaptobrevin and SNAP-25 during Exocytosis of Histamine by Rat Gastric Enterochromaffin-Like Cells* (1997)

Gastric enterochromaffin-like (ECL) cells release histamine upon stimulation with gastrin in a calcium-dependent manner. The intracellular mechanisms and proteins mediating exocytosis of histamine-containing vesicles in ECL cells have not been determined yet. We used immunocytochemistry to show the localization of SNAP-25 (synaptosome-associated protein of 25 kDa) and synaptobrevin VAMP (vesicle-associated membrane protein) in ECL cells of the rat gastric mucosa and in isolated, highly enriched ECL cells, which were identified with an antibody directed against the marker enzyme histidine decarboxylase. Immunoblots of isolated ECL cells demonstrated the presence of SNAP-25, synaptobrevin, synaptophysin, synaptotagmin, and syntaxin. Histamine release from isolated ECL cells permeabilized with 8 microM digitonin (2 min) was stimulated approximately 2.5-fold upon exposure to calcium (30 microM; 10-min incubation). Preincubation with 1 microM tetanus toxin light chain for 15 min attenuated calcium-induced histamine release by 40-50% and almost completely cleaved synaptobrevin. Botulinum neurotoxin A (100 nM) totally blocked calcium-induced histamine release and cleaved SNAP-25. We conclude that synaptobrevin, synaptophysin, synaptotagmin, SNAP-25, and syntaxin are present in gastric ECL cells. Inhibition of histamine secretion by clostridial neurotoxins associated with the cleavage of synaptobrevin and SNAP-25 implicates the functional importance of these proteins in the docking and fusion of histamine vesicles.
Molecular Pathways: Deregulation of Histone H3 Lysine 27 Methylation in Cancer—Different Paths, Same Destination (2014)

Methylation of lysine 27 on histone H3 (H3K27me), a modification associated with gene repression, plays a critical role in regulating the expression of genes that determine the balance between cell differentiation and proliferation. Alteration of the level of this histone modification has emerged as a recurrent theme in many types of cancer, demonstrating that either excess or lack of H3K27 methylation can have oncogenic effects. Cancer genome sequencing has revealed the genetic basis of H3K27me deregulation, including mutations of the components of the H3K27 methyltransferase complex PRC2 and accessory proteins, and deletions and inactivating mutations of the H3K27 demethylase UTX in a wide variety of neoplasms. More recently, mutations of lysine 27 on histone H3 itself were shown to prevent H3K27me in pediatric glioblastomas. Aberrant expression or mutations in proteins that recognize H3K27me3 also occur in cancer and may result in misinterpretation of this mark. In addition, due to the cross-talk between different epigenetic modifications, alterations of chromatin modifiers controlling H3K36me, or even mutations of this residue, can ultimately regulate H3K27me levels and distribution across the genome. The significance of mutations altering H3K27me is underscored by the fact that many tumors harboring such lesions often have a poor clinical outcome. New therapeutic approaches targeting aberrant H3K27 methylation include small molecules that block the action of mutant EZH2 in germinal center-derived lymphoma. Understanding the biologic consequences and gene expression pathways affected by aberrant H3K27 methylation may also lead to other new therapeutic strategies.
Systemic Lupus erythematosus following Hepatitis B Vaccine (1996)

Letters| December 24 2008 Systemic Lupus erythematosus following Hepatitis B Vaccine Subject Area: Nephrology José Guiserix José Guiserix Service de Néphrologie-Dialyse, Saint-Pierre, Réunion, France Search for other works by this author on: This Site PubMed Google Scholar Nephron (1996) 74 (2): 441. https://doi.org/10.1159/000189357 Article history Published Online: December 24 2008 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation José Guiserix; Systemic Lupus erythematosus following Hepatitis B Vaccine. Nephron 1 February 1996; 74 (2): 441. https://doi.org/10.1159/000189357 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsNephron Search Advanced Search This content is only available via PDF. 1996Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Article PDF first page preview Close Modal You do not currently have access to this content.
Enantioselective Organocatalytic Diels Aminations: α-Aminations of Cyclic β-Keto Esters and β-Keto Lactones with Cinchonidine and Cinchonine (2004)

Catalytic enantioselective α-amination reactions of β-keto esters and β-keto lactones with dibenzyl azodicarboxylate are catalyzed by cinchona alkaloids, affording the products in up to 99% yield and 90% ee.