gebhart/patrepeval huggingface dataset:
Impermeability of rabbit erythrocytes to prostaglandins (1975)

Washed rabbit erythrocytes were suspended in Tris-electrolyte buffer containing [3H]prostaglandin (PG) E1, F1alpha, F2alpha, or A1 and one 14C-labeled compound such as sucrose. After up to 24 h of incubation, aliquots of centrifuged, packed cells and supernatant were oxidized and the 3H and 14C samples were counted. The mean sucrose space of the packed cell was 7.4%. After 1 min the E1, F1alpha, and F2alpha spaces were 16, 15.4, and 10.0%, respectively, and showed no increase even after 24 h of incubation at either 23 or 5 degrees C. At 23 degrees C the initial (0.5 min) PGA1 and thiourea spaces were 94 and 75%, respectively, whence the PGA1, but not the thiourea, space declined, reaching 30% at 4 h. The large initial uptake of PGA1 was eliminated at 5 degrees C, while it was accentuated at pH 6.8 or at a PGA1, concentration of 10(-3) M. 14C-Labeled arachidonic, octanoic, and other non-PG fatty acids gave apparent distribution spaces of 140-300%. These results show that PG's can partition into rabbit erythrocyte membranes, but the intracellular volume of the erythrocytes is not freely accessible to these autacoids. The implications of the finding that some cell membranes are impermeable to prostaglandins are discussed.
A computational model of the log-polar retina mosaic for local feature extraction (2010)

This paper presents insights gained from applying biological vision mechanisms in the context of computer vision algorithm design, implementation and initial evaluation. In this paper a software-based space variant log(z) retina tessellation is used to sample the underlying image, maintaining the high resolution at the central foveal region and an increasingly sparse sampling density at the surrounding peripheral region, in a manner similar to that found in biological vision. This multiresolution sampling strategy differs fundamentaly from conventional image processing where whole field-of-view is processed with equal emphasis. We compare the log(z) retina tessellation sampling quality using simple point based to that of “touching circle” receptive field (RF) sampling. Multi-resolution, space-variant visual information is extracted on a scale-space continuum and SIFT features are then extracted from back-projected retinal response images for matching and recognition.
Missing the memory wall (1996)

Current high performance computer systems use complex, large superscalar CPUs that interface to the main memory through a hierarchy of caches and interconnect systems. These CPU-centric designs invest a lot of power and chip area to bridge the widening gap between CPU and main memory speeds. Yet, many large applications do not operate well on these systems and are limited by the memory subsystem performance.This paper argues for an integrated system approach that uses less-powerful CPUs that are tightly integrated with advanced memory technologies to build competitive systems with greatly reduced cost and complexity. Based on a design study using the next generation 0.25µm, 256Mbit dynamic random-access memory (DRAM) process and on the analysis of existing machines, we show that processor memory integration can be used to build competitive, scalable and cost-effective MP systems.We present results from execution driven uni- and multi-processor simulations showing that the benefits of lower latency and higher bandwidth can compensate for the restrictions on the size and complexity of the integrated processor. In this system, small direct mapped instruction caches with long lines are very effective, as are column buffer data caches augmented with a victim cache.
Detection and prevention of MAC layer misbehavior in ad hoc networks (2004)

Selfish behavior at the MAC layer can have devastating side effects on the performance of wireless networks, similar to the effects of DoS attacks. In this paper we focus on the prevention and detection of the manipulation of the backoff mechanism by selfish nodes in 802.11. We first propose an algorithm to ensure honest backoffs when at least one, either the receiver or the sender is honest. Then we discuss detection algorithms to deal with the problem of colluding selfish nodes. Although we have focused on the MAC layer of 802.11, our approach is general and can serve as a guideline for the design of any probabilistic distributed MAC protocol.
Ultrasonic Reflectoscope with an Indicator of the Degree of Coupling between Transducer and Object (1958)

A further development of Firestone's Reflectoscope is described, indicating the degree of coupling between transducer and the test object. It is shown that the distortion of a radio-frequency pulse—produced by the transducer—is a function of its coupling to the test object. Therefore, the distortion can be used to measure the coupling. The trailing edge of the radio-frequency pulse is amplified by a time-selective amplifier, rectified and connected to a galvanometer. Different conditions of coupling are analyzed. Figures are given for a barium titanate transducer working at 500 kcps. References such as back boundaries are no longer necessary in the field of nondestructive testing.
Mapping Data-Parallel Tasks Onto Partially Reconfigurable Hybrid Processor Architectures (2006)

Reconfigurable hybrid processor systems provide a flexible platform for mapping data-parallel applications, while providing considerable speedup over software implementations. However, the overhead for reconfiguration presents a significant deterrent in mapping applications onto reconfigurable hardware. Partial runtime reconfiguration is one approach to reduce the reconfiguration overhead. In this paper, we present a methodology to map data-parallel tasks onto hardware that supports partial reconfiguration. The aim is to obtain the maximum possible speedup, for a given reconfiguration time, bus speed, and computation speed. The proposed approach involves using multiple, identical but independent processing units in the reconfigurable hardware. Under nonzero reconfiguration overhead, we show that there exists an upper limit on the number of processing units that can be employed beyond which further reduction in execution time is not possible. We obtain solutions for the minimum processing time, the corresponding load distribution, and schedule for data transfer. To demonstrate the applicability of the analysis, we present the following: 1) various plots showing the variation of processing time with different parameters; 2) hardware simulations for two examples, viz., 1-D discrete wavelet transform and finite impulse response filter, targeted to Xilinx field-programmable gate arrays (FPGAs); and 3) experimental results for a hardware prototype implemented on a FPGA board
Analysis and scaling of Kelvin resistors for extraction of specific contact resistivity (1985)

An accurate numerical analysis of Kelvin resistors used for direct interfacial contact resistance measurements is presented. Curves that allow extraction of true specific contact resistivity from measured specific contact resistivity are given for different ratios of square contact window size (l) to square diffusion tap width (w). Scaling transformations are proposed to extract curves for different feature sizes. It has been shown that when l is made smaller than w, the extracted value of the specific contact resistivity (ρ <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ce</inf> ) can be significantly higher than the true specific contact resistivity (ρ <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</inf> ), especially for low values of ρ <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</inf> .
Integrating feature and instance selection for text classification (2002)

Instance selection and feature selection are two orthogonal methods for reducing the amount and complexity of data. Feature selection aims at the reduction of redundant features in a dataset whereas instance selection aims at the reduction of the number of instances. So far, these two methods have mostly been considered in isolation. In this paper, we present a new algorithm, which we call FIS (Feature and Instance Selection) that targets both problems simultaneously in the context of text classificationOur experiments on the Reuters and 20-Newsgroups datasets show that FIS considerably reduces both the number of features and the number of instances. The accuracy of a range of classifiers including Naïve Bayes, TAN and LB considerably improves when using the FIS preprocessed datasets, matching and exceeding that of Support Vector Machines, which is currently considered to be one of the best text classification methods. In all cases the results are much better compared to Mutual Information based feature selection. The training and classification speed of all classifiers is also greatly improved.
Kinetics and mechanism of wet oxidation of Ge<i>x</i>Si1−<i>x</i> alloys (1994)

The thermal oxidation of polycrystalline GexSi1−x (0.10≤x≤0.47) and pseudomorphic Ge0.2Si0.8 has been studied in wet ambient at 550 to 900 °C. A uniform GexSi1−xO2 oxide is observed by backscattering spectrometry for a high Ge content at low oxidation temperatures; a SiO2 oxide is obtained for a low Ge content at high temperatures; a GeySi1−yO2 oxide with reduced Ge content (y&lt;x) is found in between. Ge piles up behind the oxide when SiO2 or GeySi1−yO2 form. The transition between these three types of oxides also depends on the crystallinity of the GeSi alloy. When a uniform GexSi1−xO2 oxide grows, its thickness is proportional to the square root of the oxidation duration, which indicates that the rate-limiting process is the diffusive transport across the oxide of, most probably, the oxidant. The rate increases with the Ge content in the alloys. The proportionality constant, B, for this process is B(T)=[(1.0±0.2)×1011 nm2/h]exp[(−1.1±0.2 eV)/kT] for Ge0.47Si0.53. It is proposed that, in general, the oxidation behavior is determined by the competition between the speed of the diffusive process in the unoxidized GeSi alloy and the velocity at which the oxidation front progresses. The controlling factors are the oxidation temperature, the composition, and the structure of the GexSi1−x alloy. A model is proposed that is based on these three factors. Analogies with this system exist where all three elements are solid.
Carbon-13 magnetic resonance spectroscopy. Spectrum of proline in oligopeptides (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCarbon-13 magnetic resonance spectroscopy. Spectrum of proline in oligopeptidesDouglas E. Dorman and Frank A. BoveyCite this: J. Org. Chem. 1973, 38, 13, 2379–2383Publication Date (Print):June 1, 1973Publication History Published online1 May 2002Published inissue 1 June 1973https://pubs.acs.org/doi/10.1021/jo00953a021https://doi.org/10.1021/jo00953a021research-articleACS PublicationsRequest reuse permissionsArticle Views669Altmetric-Citations250LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Serum estradiol levels associated with specific gene expression patterns in normal breast tissue and in breast carcinomas (2011)

We have identified genes associated with serum estradiol levels in normal breast tissue and in breast carcinomas. SCGB3A1 is a suggested tumor suppressor gene that inhibits cell growth and invasion and is methylated and down-regulated in many epithelial cancers. Our findings indicate this gene as an important inhibitor of breast cell proliferation in healthy women with high estradiol levels. In the breast, this gene is expressed in luminal cells only and is methylated in non-BRCA-related breast cancers. The possibility of a carcinogenic contribution of silencing of this gene for luminal, but not basal-like cancers should be further explored. PTGS1 induces prostaglandin E2 (PGE2) production which in turn stimulates aromatase expression and hence increases the local production of estradiol. This is the first report studying such associations in normal breast tissue in humans.
Anemia, Shortened Erythrocyte Lifespan and Stomatocytosis In a Flippase Mutant Mouse Strain (2013)

Abstract Background Mammalian erythrocytes are anucleate biconcave discs with marked flexibility and deformability, features necessary for efficient function. The cell membrane consists of a lipid bilayer containing proteins and an asymmetric distribution of phospholipids (PL). Phosphatidylcholine and sphingomyelin are predominantly concentrated in the outer layer and phosphatidylserine (PS) and phosphatidylethanolamine are mainly confined to the inner layer of the erythrocyte membrane. Maintenance of PL asymmetry is essential for erythrocyte survival and function as increased externalization of PS results in adherence of erythrocytes to vascular endothelium, activation of plasma blood clotting factors and premature removal from the circulation. Flippases, floppases and scramblases are the enzymes responsible for the establishment and maintenance of PL distribution. A mouse deficient in the flippase ATP11C was generated through ENU mutagenesis and was found to have reduced hemoglobin in comparison to wild type (WT) littermates. This study was performed to characterize the etiology of anemia in these mice. Results ATP11C-deficient mice had significant reductions in erythrocyte numbers and hematocrit compared to WT but higher MCH and MCV. Reticulocyte numbers were comparable to WT as were serum iron parameters. Bone marrow and splenic erythropoiesis was normal in ATP11C mutant mice, however, erythrocyte lifespan was reduced by 35%. A marked increase in the frequency of PS+ erythrocytes was demonstrated in ATP11C mutant mice and was shown to increase with erythrocyte age. Bone marrow and splenic erythroblasts from ATP11C-deficient animals displayed a lower rate of PS translocation in vitro compared to WT confirming defective flippase activity. Erythrocytes and late-stage splenic erythroblasts in ATP11C mutants were significantly larger than WT based on flow cytometry. SEM revealed the majority of mutant erythrocytes displayed stomatocyte-like morphology, as confirmed on peripheral blood smears. The osmotic fragility of the ATP11C-deficient erythrocytes was comparable to WT erythrocytes as was Na+ and K+ homeostasis. Discussion These studies reveal the important role of flippases in maintaining normal erythrocyte function through the maintenance of the asymmetric distribution of PS within the membrane. Perturbation of this process, as seen in the ATP11C-deficient mice, results in (i) increased exposure of PS on the erythrocyte outer membrane, (ii) increased size of late-stage erythroblasts and erythrocytes with stomatocyte formation (iii) reduced erythrocyte lifespan and (iv) normochromic anemia. This study, therefore, reveals a new mechanism for stomatocytosis and raises the question of whether mutations in ATP11C may serve as a previously unclassified cause of anemia in humans. Disclosures: No relevant conflicts of interest to declare.
A New Resonant Gate Drive Circuit for Synchronous Buck Converter (2007)

This paper proposes a new resonant gate drive circuit for driving both the control metal oxide semiconductor field effect transistor (MOSFET) and synchronous MOSFET in a synchronous buck converter. The circuit can recover more than 70% of the conventional gate drive loss. More importantly, the driving circuit can also reduce the switching loss. It charges and discharges the gate of MOSFET at a constant current during switching interval. Other advantages of the proposed circuit include better noise immunity for dv/dt turn on, less sensitive to parasitic track inductance. The experimental prototype shows that the loss reduction is 10% of the output power for 12 V input, 1.5 V/15 A output with switching frequency of 1 MHz.
Improving fluoroscopic image quality with continuously variable zoom magnification (1991)

Coning down is commonly used during fluoroscopy to increase image contrast by reducing scatter. However, the resulting image fills only part of a video display whose resolution is limited by line rate and bandwidth. Optical or electron-optical zooming can be used to magnify the collimated image so that it fills a larger fraction of the viewable area of the video frame to make more effective use of the available video-display capacity. Modulation-transfer functions (MTFs) were measured for various zoom factors achieved using a zoom lens and the image-intensifier (II) electronic magnification mode. Significant and continuing improvement in total system MTF was observed up to zoom magnifications of greater than 3.3. For larger zoom factors, the resolution limit becomes dominated by the intrinsic resolving power of the II and by geometric unsharpness rather than by the line rate of the video system. When the MTF at infinite zoom factor, obtained by extrapolation, was divided into the measured MTFs, the resultant MTFz's were shown to scale predictably with zoom factor. Only a slight improvement in MTF was obtained using the II's electronic magnification mode compared to the same magnification using a zoom lens. It is concluded that, if improved image quality is the motivation for the use of coning down in fluoroscopy, then zooming to use fully the available video frame is warranted.
ChemInform Abstract: Mechanized Materials (2011)

Abstract Review: 113 refs.
Field experiments with a wind tunnel on the flight speed of some west African mosquitoes (Diptera: Culicidae) (1981)

Abstract An open wind tunnel, down which air was blown from over a bait animal, was used in the field in the Gambia to measure the flight speed of host-seeking mosquitoes. Insects were trapped on an electrocuting grid fitted halfway up the tunnel. As the speed of air movement through the electrocuting grid was increased from 0·5 m/s, catches of Mansonia spp. fell off steeply, reaching negligible levels above 1·4 m/s. At air speeds lower than 0·5 m/s, catches at the grid were greatly reduced. Similar results were obtained for Anopheles ziemanni Griinb. and other species of Anopheles . It is concluded that the maximum flight speed of hostseeking females of all these species was in the range 1·4–1·8 m/s.
Identification of volatile lung cancer markers by gas chromatography–mass spectrometry: comparison with discrimination by canines (2012)

In this work, a chromatographic method for identification of volatile organic compounds was compared with canine recognition. Gas chromatography and mass spectrometry (GC-TOF MS) were used for determination of concentrations of trace gases present in human breath. The technique enables rapid determination of compounds in human breath, at the parts per billion level. Linear correlations were from 0.83-234.05 ppb, the limit of detection was the range 0.31-0.75 ppb, and precision, expressed as relative standard deviation (RSD), was less than 10.00 %. Moreover, trained dogs are able to discriminate breath samples of patients with diagnosed cancer. We found a positive correlation between dog indications and the ethyl acetate and 2-pentanone content of breath (r = 0.85 and r = 0.97, respectively). The methods presented for detection of lung cancer markers in exhaled air could be used as a potential non-invasive tool for screening. In addition, the canine method is relatively simple and inexpensive in comparison with chromatography.
Acoustic microscopy of rocks (1990)

SUMMARY Acoustic images of two common rocks, granodiorite and limestone, are studied to explore the kind of geological information that they can provide. The contrast is primarily due to Rayleigh waves; in rock specimens they are mainly affected in their propagation by crystal anisotropy and surface discontinuities. Therefore, acoustic microscopy makes possible detailed identification of intragranular structures in the rock‐forming minerals (very fine cracks, grain and subgrain boundaries, etc.); these features may appear more sharply than in transmitted polarized light microscopy or in scanning electron microscopy. In particular the acoustic images are effective in microfractographic studies, they can show not only the finest cracks, even those much less than a wavelength wide, but also their position in relation to the grain and subgrain structure.
[Disorders of the immune status in patients with acute diffuse peritonitis]. (1991)

Analysis of various parameters of the immune system and non-specific resistance in patients with acute generalized peritonitis (AGP) has indicated that in AGP there is immunodeficiency involving all the links of immune defense and non-specific resistance. The T-cell immunity, primarily T helpers, is afflicted in AGP to the greatest extent. A magnitude of decreases in T helper counts may be used as a prognostic indicator in AGP. The severity of immune defense abnormalities correlates with the duration and intensity of intoxication, there is a "paralysis" of this defense in the terminal stage of AGP.
Regulatory mechanisms for production of IFN-<i>gamma</i> and TNF by antitumor T cells or macrophages in the tumor-bearing state. (1995)

Spleen cells from BALB/c mice bearing a syngeneic tumor (CSA1 M) 2 to 3 wk after inoculation with CSA1 M cells produced IL-2, IFN-gamma, and TNF upon in vitro cultures. This was previously demonstrated to be a result of collaboration between tumor-primed CD4+ T cells and APCs binding CSA1 M tumor Ags in vivo. The IL-2- and IFN-gamma-producing capacities decreased with the progress of tumor-bearing stages. This was parallel to the levels of IL-2 and IFN-gamma mRNAs expressed by cultured spleen cells. In contrast, comparable levels of TNF mRNA were expressed by all groups of cultured cells. However, large amounts of TNF were secreted by the cells from early but not from late tumor-bearing mice. TNF was produced mainly by the non-T cell fraction upon stimulation with CD4+ T cell-derived IFN-gamma. Therefore, the reduced TNF production by whole spleen cells from late tumor-bearing mice was restored by addition of rIFN-gamma to their cultures. Reciprocally to the progressive decrease in the production of IFN-gamma/TNF, the capacities of tumor-bearing mice to produce TGF-beta and IL-6 increased along with tumor growth. TGF-beta suppressed production of IL-2, IFN-gamma, and TNF, but not of IL-6. Moreover, IFN-gamma/TNF production was negatively regulated by IL-6. Taken together with the fact that the growth of CSA1 M cells is completely inhibited by the combination of TNF and IFN-gamma, these results demonstrate that the tumor-bearing state induces an abnormal cytokine network under which the production of antitumor cytokines is negatively regulated.