gebhart/patrepeval huggingface dataset:
Sequence of human adenogine deaminase cDNA Including the coding region and a small Intron (1984)

The nucleotide sequence for an unusual, cloned human adenosine deaminase cDNA has been determined. Contained within a sequence of 1535 nucleotides is a coding sequence of 1089 nucleotides that encodes a protein of 40,762 daltons. The coding sequence is interrupted by a non-coding region containing 76 nucleotides. Both the 3' and 5' ends of this region have consensus sequences generally associated with splice sites. The 3' untranslated sequence contained 308 nucleotides, including a polyadenylation signal sequence 20 nucleotides from the end. The cloned cDNA appears to correspond to a nuclear mRNA precursor which contains a small intron.
Illumination-Level Adaptive Color Reproduction Method with Lightness Adaptation and Flare Compensation for Mobile Display (2007)

Mobile displays such as personal digital assistants and cellular phones encounter various illumination levels, different from the flat panel displays mainly used in indoor environment. In particular, in the daylight condition, the displayed images or text on a mobile display can be darkly perceived, which results in the degradation of sun readability in a mobile display. To overcome this problem, we proposed an illumination level adaptive color reproduction method with a lightness adaptation model and flare compensation. Lightness adaptation is a physiological mechanism to shift the photoreceptor response curve according to the illumination level. Thus, as a mobile phone is carried from an indoor to outdoor environment, the photoreceptor response curve automatically shifts toward a higher luminance to adapt to daylight intensity. Consequently, for a lower intensity emitted from the mobile display, the photoreceptor response curve becomes less sensitive, thereby decreasing the perceived brightness of the displayed image. Moreover, colors produced by mobile display can also be influenced by the flare, defined as ambient light reflected from the display panel, which reduces the maximum chroma of the mobile display gamut. Based on these physiological and physical phenomena, the lightness values of the input image are enhanced by making a linear relation between input luminance value estimated by device characterization and photoreceptor response value calculated from the lightness adaptation model. For the chroma component of the lightness-enhanced input image, chroma compensation is conducted by adding the chroma values of the flare multiplied by the enhancement parameter, depending on the hue plane of the gamut boundary. Throughout the experiment, the proposed algorithm not only reproduces bright and colorful images in the mobile display under daylight conditions, but also produces a solution to improve sunlight readability.
Autonomous Vehicle Dispatching for Person Evacuation (2019)

The rapid development of Autonomous Vehicle (AV) technologies provides a new opportunity to evacuate vulnerable persons from their residences to shelters when some emergency event happens. One of the most important objectives is to minimize the evacuation time, which depends on the order to evacuate persons and which shelter each person is delivered to. We first formulate this AV dispatching problem as an Integer Linear Programming (ILP) model and prove this problem is NP-hard. Due to the problem hardness, an efficient algorithm based on Dynamical Programming (DP) is proposed. Through extensive simulations, we find that our algorithm can reduce the evacuation time by 58\% compared with a greedy based algorithm, which is the common method to solve the Traveling Salesman Problem (TSP), a special case of our AV dispatching problem.
High-speed monolithic p-i-n/HBT and HPT/HBT photoreceivers implemented with simple phototransistor structure (1993)

Monolithic photoreceivers, using the base-collector junction of an InP/InGaAs phototransistor structure for a p-i-n photodetector, have been fabricated for the first time. Bandwidths as high as 3 GHz and bit rates as high as 5 Gb/s, with sensitivities of -22.5 dBm and -21.5 dBm for light focused on the p-i-n or on the first stage transistor of the preamplifier, respectively, have been achieved. These results represent the highest operating speed demonstrated for any phototransistor-based receiver.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Advanced Graphics Programming Using C/C++ (1993)

Adding a Lighting Model An Enhanced Ray Tracer Creating a World Textures and Patterns Adding Animation Rendering Water and Clouds Rendering Fractal Mountains A PCX Toolkit TIFF: A Flexible Image File Format Image Processing Essentials Morphing Magic Appendices Index.
In Vitro Performance of the Novel Coronary Sinus AutoRetroPerfusion Cannula (2005)

Myocardial salvage through coronary sinus intervention has been documented. The AutoRetroPerfusion Cannula is a novel device that is able to perfuse the coronary bed retrogradely through the coronary sinus with arterial blood generated from a peripheral artery with no need for a pump. The cannula consists of a distal end that, once secured in the coronary sinus, opens an umbrella-like membrane to create pressure in the coronary sinus, and at the same time has small channels directed backwards to the right atrium to provide pressure relief. The cannula is introduced from the axillary vein under local anesthesia and the proximal end, which consists of a graft, is anastomosed to the axillary artery to start autoperfusion once the distal end is secured in the coronary sinus and the occluding membrane is open. The AutoRetroPerfusion Cannula was tested in the in vitro mock loop under 50-120 mm Hg of proximal pressure and 50, 100, and 150 ml/min of total flow in the cannula. We were able to achieve the nominal design point of 40-80 mm Hg of distal pressure and 50-150 ml/min of distal flow by adjusting the number, diameter, and length of the small backwards channels.
Modeling of Hydrate Deposition in Loading and Offloading Flowlines of Marine CNG Systems (2015)

The main aim of this paper is to demonstrate the prediction of the model capability of predicting the nucleation process, the growth rate, and the deposition potential of hydrate particles in gas flowlines. The primary objective of the research is to predict the risk hazards involved in the marine transportation of compressed natural gas. However the proposed model can be equally used for other applications including production and transportation of natural gas in any high pressure flowline. The proposed model employs the following three main components to approach the problem: computational fluid dynamics (CFD) technique is used to configure the flow field; the nucleation model is developed and incorporated in the simulation to predict the incipient hydrate particles size and growth rate; and the deposition of the gas/particle flow is proposed using the concept of the particle deposition velocity. These components are integrated in comprehended model to locate the hydrate deposition in natural gas flowlines. The present research is prepared to foresee the hydrate deposition location that could occur in a real application in Compressed Natural Gas loading and offloading. A pipeline with 120 m length and different sizes carried a natural gas is taken in the study. The location of hydrate deposition formed as a result of restriction is determined based on the procedure mentioned earlier and the effect of water content and downstream pressure is studied. The critical flow speed that prevents hydrate to accumulate in the certain pipe length is also addressed.
SOCIAL VALIDITY: THE CASE FOR SUBJECTIVE MEASUREMENT or HOW APPLIED BEHAVIOR ANALYSIS IS FINDING ITS HEART<sup>1</sup> (1978)

I apologize, but I must begin making my case for subjective measurement by recounting to you my own experiences with it over the past few years. Almost a decade ago, when the field of applied behavior analysis was beginning to expand so rapidly, we were faced with the task of putting together the Journal of Applied Be- havior Analysis. For a period of several months Garth Hopkins, who was our managing editor, presented us with a series of unexpected deci- sions to make; like: What color should the paper be? And did we need a paper that would hold together for two thousand years or were we willing to live with a shelf-life of only a thousand years? And so on.
Incorporation of optimal timeouts into distributed real-time load sharing (1994)

Consideration is given to the problem of designing and incorporating a timeout mechanism into load sharing (LS) with state-region change broadcasts in the presence of node failures in a distributed real-time system. Failure of a node is diagnosed by the other nodes through communication timeouts, and the timeout period used to diagnose whether a node is faulty or not usually depends on the dynamic changes in system load, the task attributes at the node, and the state the node was initially in. We formulate the problem of determining the "best" timeout period T/sub out//sup (i)/ for node i as a hypothesis testing problem, and maximize the probability of detecting node failures subject to a pre-specified probability of falsely diagnosing a healthy node as faulty. The parameters needed for the calculation of T/sub out//sup (i)/ are estimated online by node i using the Bayesian technique and are piggy-backed in its region-change broadcasts. The broadcast information is then used to determine T/sub out//sup (i)/. If node n has not heard from node i for T/sub out//sup (i)/ since its receipt of the latest broadcast from node i, it will consider node i failed, and will not consider any task transfer to node i until it receives a broadcast message from node i again. On the other hand, to further reduce the probability of incorrect diagnosis, each node n also determines its own timeout period T/sub out//sup (n)/, and broadcasts its state not only at the time of state-region changes but also when it has remained within a broadcast interval throughout T/sub out//sup (n)/.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Modeling score distributions for combining the outputs of search engines (2001)

In this paper the score distributions of a number of text search engines are modeled. It is shown empirically that the score distributions on a per query basis may be fitted using an exponential distribution for the set of non-relevant documents and a normal distribution for the set of relevant documents. Experiments show that this model fits TREC-3 and TREC-4 data for not only probabilistic search engines like INQUERY but also vector space search engines like SMART for English. We have also used this model to fit the output of other search engines like LSI search engines and search engines indexing other languages like Chinese.
In-vitro renal epithelial cell infection reveals a viral kidney tropism as a potential mechanism for acute renal failure during Middle East Respiratory Syndrome (MERS) Coronavirus infection (2013)

Epidemiological studies should analyze kidney impairment and its characteristics in MERS-CoV. Virus replication in the kidney with potential shedding in urine might constitute a way of transmission, and could explain untraceable transmission chains leading to new cases. Individual patients might benefit from early induction of renoprotective treatment.
Genistein downregulates onco-miR-1260b and upregulates sFRP1 and Smad4 via demethylation and histone modification in prostate cancer cells (2014)

Our data suggest that genistein exerts its anti-tumour effect via downregulation of miR-1260b that targeted sRRP1 and Smad4 genes in prostate cancer cells. The expression of sFRP1 and Smad4 was also modulated by genistein via DNA methylation or histone modifications in PC cell lines.
Response of neural precursor cells in the brain of Parkinson's disease mouse model after LIF administration (2008)

LIF may be a useful treatment for PD by up-regulating the re-expression of NPCs, which may represent the neuroprotection mechanism of LIF.
Carbon monoxide and mitochondriaâ€”modulation of cell metabolism, redox response and cell death (2015)

Carbon monoxide (CO) is an endogenously produced gasotransmitter, which is associated with cytoprotection and cellular homeostasis in several distinct cell types and tissues. CO mainly targets mitochondria because: (i) mitochondrial heme-proteins are the main potential candidates for CO to bind, (ii) many CO's biological actions are dependent on mitochondrial ROS signaling and (iii) heme is generated in the mitochondrial compartment. Mitochondria are the key cell energy factory, producing ATP through oxidative phosphorylation and regulating cell metabolism. These organelles are also implicated in many cell signaling pathways and the production of reactive oxygen species (ROS). Finally, mitochondria contain several factors activating programmed cell death pathways, which are released from the mitochondrial inter-membrane space upon mitochondrial membrane permeabilization. Therefore, disclosing CO mode of action at mitochondria opens avenues for deeper understanding CO's biological properties. Herein, it is discussed how CO affects the three main aspects of mitochondrial modulation of cell function: metabolism, redox response and cell death.
Synthesis and characterization of gold(I) thiolates, selenolates, and tellurolates: x-ray crystal structures of Au4[TeC(SiMe3)3]4, Au4[SC(SiMe3)3]4, and Ph3PAu[TeC(SiMe3)3] (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and characterization of gold(I) thiolates, selenolates, and tellurolates: x-ray crystal structures of Au4[TeC(SiMe3)3]4, Au4[SC(SiMe3)3]4, and Ph3PAu[TeC(SiMe3)3]Philip J. Bonasia, David E. Gindelberger, and John ArnoldCite this: Inorg. Chem. 1993, 32, 23, 5126–5131Publication Date (Print):November 1, 1993Publication History Published online1 May 2002Published inissue 1 November 1993https://doi.org/10.1021/ic00075a031RIGHTS & PERMISSIONSArticle Views533Altmetric-Citations99LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (748 KB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Anatomical-Functional Correlative Analysis Of The Human Brain Using Three Dimensional Imaging Systems (1989)

Quantitative interpretation of functional images (PET or SPECT) is hampered by poor spatial resolution, low counting statistics and, for many tracers, low contrast between different brain structures of interest. Further, normal tracer distributions can be severely distorted by such gross pathologies as stroke, tumor and dementia. Hence, the complementary anatomical information provided by CT or MRI is essential for accurate and reproducible regional analysis of functional data. We have developed methods for the three-dimensional integration and simultaneous display of image volumes from MRI and PET. PET data was collected from an older Therascan 3-slice scanner with 12 mm resolution and a 15-slice Scanditronix PC-2048 system having 5-6 mm resolution in each dimension. MRI data was obtained from a Philips 1.5 Tesla Gyroscan scanner. The image volumes were loaded into a PIXAR 3-D image computer for simultaneous display. A general algorithm for finding the optimal transformation between two ensembles of equivalent points was implemented and investigated through simulation studies. Using a locally-developed 3-D image/graphics analysis package, equivalent points in the two image volumes were identified, either manually or via an adjustable computerized volume-of-interest (VOI) atlas. The MRI data were then re-sampled along planes parallel to the PET planes and the two volumes overlaid using opacity-weighted composition. Arbitrary oblique planes through the two volumes were obtained in interactive sessions.
Sumatriptan, a selective 5-HT1 receptor agonist, induces a lag phase for gastric emptying of liquids in humans (1997)

Sumatriptan, a 5-hydroxytryptamine1 (5-HT1) receptor agonist at enteric neuronal 5-HT receptors, causes a relaxation of the gastric fundus and inhibition of antral contractile activity. The present study examined the effect of sumatriptan on gastric emptying of solids and liquids in humans. In eight healthy subjects the gastric emptying rate for liquids and solids was measured using the carbon-labeled glycine and octanoic acid breath test after subcutaneous administration of placebo or sumatriptan. Sumatriptan increased the gastric half-emptying time of liquids (P < 0.0005) and induced a prolonged lag phase for liquids (P < 0.0005) in all subjects. Sumatriptan increased gastric half-emptying time (P < 0.005) and the lag phase of solids (P < 0.05) in all subjects. In two healthy subjects gastric emptying of liquids and solids after subcutaneous administration of sumatriptan was studied by radioscintigraphy. Radioscintigraphy confirmed the delayed emptying and the prolonged lag phases after sumatriptan. In conclusion, sumatriptan delays gastric emptying of solids and liquids in healthy subjects. Moreover, sumatriptan induces a lag phase for liquids. The mechanism by which sumatriptan alters gastric emptying remains to be studied.
Elastic behaviour of the carotid artery in intact spontaneously hypertensive rats (1993)

Intact spontaneously hypertensive rats (SHR) were studied to assess the effect of prolonged antihypertensive treatment on the elastic behaviour of the external carotid artery. Thirty-week-old SHR received the ACE inhibitor captopril, the arteriolar dilator hydralazine or their vehicle for 6 weeks. These rats were compared to normotensive, vehicle treated WKY rats. The internal diameter of the carotid artery was measured continuously in halothane-anaesthetized rats using an echo-tracking device, and intra-arterial pressure was also monitored continuously, on the contralateral side. Captopril- and hydralazine-treated SHR as well as normotensive controls had similar blood pressure values. No significant shift in the distensibility-pressure curves was observed among vehicle-treated SHR and WKY rats or the SHR which had received captopril or hydralazine. Histological examination of the carotid artery fixed ex vivo with paraformaldehyde showed a significant increase in cross-sectional area in vehicle-treated SHR as compared to their normotensive counterparts. These results therefore suggest that the elastic behaviour of elastic arteries is not necessarily altered by the structural changes developing in response to hypertension.
Phosphatidylinositol as a Component of the Ice Nucleating Site of <i>Pseudomonas syringae</i> and <i>Erwinia herbiola</i> (1984)

Phosphatidylinositol has been identified as a major component of the ice nucleating site on the outer surface of two bacteria, Pseudomonas syringae and Erwinia herbicola. Plant lectins binding to inositol and a highly purified phosphatidylinositol-specific hydrolase (a C(II) lipase) inhibited or decreased the efficiency of the ice nucleating activity (INA) of both bacteria. Extracts of these two INA(+) bacteria had phosphatidylinositol synthase activity while extracts from related INA(-) Pseudomonas or Erwinia strains had no detectable synthase activity. An Escherichia coli strain acquired phosphatidylinositol synthase activity when transformed to the INA(+) phenotype with recombinant plasmids containing fragments of P. syringae DNA.
Relative Robots: Scaling Automated Assembly of Discrete Cellular Lattices (2016)

We propose metrics for evaluating the performance of robotically assembled discrete cellular lattice structures (referred to as digital materials) by defining a set of tools used to evaluate how the assembly system impacts the achievable performance objective of relative stiffness. We show that mass-specific stiffness can be described by the dependencies E*(γ, D(n, f, RA)), where E* is specific modulus, γ is lattice topology, and the allowable acceptance of the joint interface, D, is defined by an error budget analysis that incorporates the scale of the structure, and/or number of discrete components assembled, n, the type of robotic assembler, RA, and the static error contributions due to tolerance stack-up in the specified assembler structural loop, and the dynamic error limitations of the assembler operating at specified assembly rates, f. We refer to three primary physical robotic construction system topologies defined by the relationship between their configuration workspace, and the global configuration space: global robotic assembler (GR), mobile robotic assembler (MR), and relative robotic assemblers (RR), each exhibiting varying sensitivity to static, and dynamic error accumulation. Results of this analysis inform an iterative machine design process where final desired material performance is used to define robotic assembly system design parameters.
DISCUSSION. THE DESIGN AND EQUIPMENT OF MODERN MARSHALLING YARDS. (1953)

Keywords SNCF DESIGN, EQUIPMENT, MARSHALLING, YARDS, RETARDERS, GRADIENTS, BRAKES, WAGONS, RAILWAYS, DISTRIBUTION, SPEED, HUMPING, HYDRAULICS WHITEMOOR UK, USA, FRANCE... Show All
Solution‐Processable Donor–Acceptor Polymers with Modular Electronic Properties and Very Narrow Bandgaps (2014)

Bridgehead imine-substituted cyclopentadithiophene structural units, in combination with highly electronegative acceptors that exhibit progressively delocalized π-systems, afford donor-acceptor (DA) conjugated polymers with broad absorption profiles that span technologically relevant wavelength (λ) ranges from 0.7 < λ < 3.2 μm. A joint theoretical and experimental study demonstrates that the presence of the cross-conjugated substituent at the donor bridgehead position results in the capability to fine-tune structural and electronic properties so as to achieve very narrow optical bandgaps (Eg (opt) < 0.5 eV). This strategy affords modular DA copolymers with broad- and long-wavelength light absorption in the infrared and materials with some of the narrowest bandgaps reported to date.
Genomic instability and breast cancer (2001)

The loss of genomic stability is accepted as being one of the most important aspects of cancer. The correlation between genomic instability and cancer proneness in cases of known genetic syndromes (e.g. ataxia telengectasia, Fanconi anemia) is well established. This study was conducted to assess genomic instability in 19 patients with sporadic breast cancer. We used the comet assay on the lymphocytes of patients before radiotherapy and/or chemotherapy. The alkaline comet assay (single-cell gel electrophoresis) is a sensitive and rapid method for detecting DNA damage (single strand breaks and alkali-labile sites) in G(0) cells, at a single-cell level. This assay was achieved in vitro without irradiation and after exposure (dose ranging from 50 cGy to 5 Gy). The results show that the patients have higher baseline values than controls. At 2 Gy, the mean tail moment, score and the percentage of DNA in the tail increase for both groups but these values are much higher for patients. Our results show that the lymphocyte DNA of cancer patients is more damaged than that of controls with or without irradiation. Our hypothesis is that this baseline DNA damage reflect a genomic instability in sporadic breast cancer. This instability seems to increase after in vitro irradiation.