gebhart/patrepeval huggingface dataset:
Preparation, Structure, and Applications of Thin Films of Silicon Monoxide and Titanium Dioxide (1950)

A material satisfying the chemical formula for silicon monoxide can be prepared by heating finely divided silicon and silica in vacuum. Silicon monoxide is structurally different from either silicon or silica and exists only in amorphous form. Vacuum‐deposited thin films of silicon monoxide decompose to silicon and silica when heat‐treated in an enert atmosphere and oxidize to silica when heated in air. Their oxidation rates in air at various temperatures have been measured by optical means. Silicon monoxide is especially suitable for depositing protective layers on first‐surface mirrors and for preparing replica and support films for electron microscope and electron diffraction studies. Titanium dioxide films prepared by evaporating titanium and oxidizing it in air at 400° to 500°C. have a rutile structure. Such rutile films can be used for splitting beams and for increasing the reflectivity of first‐surface mirrors.
Knowledge-based program analysis (1990)

Automatic program analysis is regarded here as both the mechanized process of understanding high-level concepts from program text and the use of those concepts to guide program maintenance. A knowledge-based program analysis tool called PAT, which realizes this concept, is described. PAT uses an object-oriented framework to represent programming concepts and a heuristic-based concept-recognition mechanism to derive high-level functional concepts from the source code. As an example, a segment of a much larger program written in a Pascal-like language is analyzed using PAT.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
[Intermittent claudication: topical treatment with isosorbide dinitrate ointment. Preliminary results]. (1981)

Following the casual observation reported by one anginal patient of ours, of improvement of its claudicatio intermittens with application of isosorbide dinitrate ointment directly on the leg suffering pain, we undertook a study to assess the possible use of the drug in peripheral vascular disease in a group of 10 patients suffering of a severe form of claudicatio intermittens. The effect of the drug was tested 1) by the subjective valuation of the patient itself 2) by treadmill stress tests performed at constant rate. In this case were used as reference parameters the distance walked without any symptoms and the maximal distance reached by each patient. The treadmill stress test was performed in basal condition and after longterm administration of isosorbide dinitrate ointment 100 mg three times a day for 30-45 days. In 5 patients the control test was repeated twice in different days to evaluate the reproducibility of the measure that resulted good, while other 5 patients performed the test one hour following the application of the drug in order to assess a possible acute effect of the drug that was not present in any patient. All the patients noted an improvement in their walking capacity but only after 15-20 days of treatment. In basal condition the distance walked without any symptoms by the patients was on the average m. 51 (+/- 52) and the maximal distance reached was m. 143 (+/- 111), while after the treatment were m. 151 (+/- 136) and m. 384 (+/- 203) with a difference highly significative (p less than 0.05 and p less than 0.01 respectively). From our data although preliminary, it is apparent that longterm local application of isosorbide dinitrate is effective in the treatment of patients with peripheral vascular disease and that the action of the drug seems to be related to a local effect.
O-alkyl O-nucleoside 3'-phosphonates as novel starting materials for oligonucleotide synthesis. (1989)

It was found that the title compounds were activated rapidly into the corresponding highly reactive phosphorochloridites by use of tris(2,4,6-tribromophenoxy)dichloro-phosphorane (BDCP) as a chlorinating reagent. The reaction was applied to the synthesis of oligodeoxyribonucleotides.
Ultrabroadband nonlinear optics in nanophotonic periodically poled lithium niobate waveguides (2020)

Quasi-phase-matched interactions in waveguides with quadratic nonlinearities enable highly efficient nonlinear frequency conversion. In this paper, we demonstrate the first generation of devices that combine the dispersion engineering available in nanophotonic waveguides with quasi-phase-matched nonlinear interactions available in periodically poled lithium niobate (PPLN). This combination enables quasi-static interactions of femtosecond pulses, reducing the pulse energy requirements by several orders of magnitude compared to conventional devices, from picojoules to femtojoules. We experimentally demonstrate two effects associated with second harmonic generation (SHG). First, we observe efficient quasi-phase-matched SHG with <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:mo><</mml:mo> </mml:mrow> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:mn>100</mml:mn> </mml:mrow> <mml:mspace width="thickmathspace"/> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:mi mathvariant="normal">f</mml:mi> <mml:mi mathvariant="normal">J</mml:mi> </mml:mrow> </mml:math> of pulse energy. Second, in the limit of strong phase-mismatch, we observe spectral broadening of both harmonics with as little as 2 pJ of pulse energy. These results lay a foundation for a new class of nonlinear devices, in which coengineering of dispersion with quasi-phase-matching enables efficient nonlinear optics at the femtojoule level.
Biomaterial-Free Three-Dimensional Bioprinting of Cardiac Tissue using Human Induced Pluripotent Stem Cell Derived Cardiomyocytes (2017)

We have developed a novel method to deliver stem cells using 3D bioprinted cardiac patches, free of biomaterials. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), fibroblasts (FB) and endothelial cells (EC) were aggregated to create mixed cell spheroids. Cardiac patches were created from spheroids (CM:FB:EC = 70:15:15, 70:0:30, 45:40:15) using a 3D bioprinter. Cardiac patches were analyzed with light and video microscopy, immunohistochemistry, immunofluorescence, cell viability assays and optical electrical mapping. Cardiac tissue patches of all cell ratios beat spontaneously after 3D bioprinting. Patches exhibited ventricular-like action potential waveforms and uniform electrical conduction throughout the patch. Conduction velocities were higher and action potential durations were significantly longer in patches containing a lower percentage of FBs. Immunohistochemistry revealed staining for CM, FB and EC markers, with rudimentary CD31+ blood vessel formation. Immunofluorescence revealed the presence of Cx43, the main cardiac gap junction protein, localized to cell-cell borders. In vivo implantation suggests vascularization of 3D bioprinted cardiac patches with engraftment into native rat myocardium. This constitutes a significant step towards a new generation of stem cell-based treatment for heart failure.
Self-ordering Electrochemistry: A Simple Approach for Engineering Nanopore and Nanotube Arrays for Emerging Applications* (2011)

In this paper, we present recent work from our group focussed on the fabrication of nanopore and nanotube arrays using self-ordered electrochemistry, and their application in several key areas including template synthesis, molecular separation, optical sensing, and drug delivery. We have fabricated nanoporous anodic aluminium oxide (AAO) with controlled pore dimensions (20–200 nm) and shapes, and used them as templates for the preparation of gold nanorod/nanotube arrays and gold nanotube membranes with characteristic properties such as surface enhanced Raman scattering and selective molecular transport. The application of AAO nanopores as a sensing platform for reflective interferometric detection is demonstrated. Finally, a drug release study on fabricated titania nanotubes confirms their potential for implantable drug delivery applications.
A novel hint-based I/O mechanism for centralized file server of cluster (2008)

In the medium and small cluster systems, the centralized file server such as NFS is the main approach to provide the storage service with low cost and easy management. However, when multiple parallel applications access the shared storage at the same time, the I/O performance decreases much because of the interference of the I/O requests coming from the different clients. In this paper, a hint-based I/O mechanism is proposed and implemented in the United-FS. By analyzing the hint information of the I/O requests, the related requests are grouped, sorted and scheduled by our hint-based I/O scheduler. The experiments show that our hint-based I/O mechanism nearly doubles the read performance compared with NFS, and has better scalability.
Design and Development of Highly Potent HIV-1 Protease Inhibitors with a Crown-Like Oxotricyclic Core as the P2-Ligand To Combat Multidrug-Resistant HIV Variants (2017)

Design, synthesis, and evaluation of a new class of exceptionally potent HIV-1 protease inhibitors are reported. Inhibitor 5 displayed superior antiviral activity and drug-resistance profiles. In fact, this inhibitor showed several orders of magnitude improved antiviral activity over the FDA approved drug darunavir. This inhibitor incorporates an unprecedented 6-5-5 ring-fused crown-like tetrahydropyranofuran as the P2 ligand and an aminobenzothiazole as the P2' ligand with the (R)-hydroxyethylsulfonamide isostere. The crown-like P2 ligand for this inhibitor has been synthesized efficiently in an optically active form using a chiral Diels-Alder catalyst providing a key intermediate in high enantiomeric purity. Two high resolution X-ray structures of inhibitor-bound HIV-1 protease revealed extensive interactions with the backbone atoms of HIV-1 protease and provided molecular insight into the binding properties of these new inhibitors.
Antienvelope antibodies are protective against GBV-C reinfection: Evidence from the liver transplant model (1998)

An assay for the detection of antibody against the second envelope (E2) protein of GB virus type C (GBV-C) has been developed. Early reports suggested that this antibody was a marker of viral clearance, yet it is unknown whether anti-E2 is protective against further GBV-C infection. The primary aims were to determine (1) if posttransplantation immunosuppression alters the prevalence of anti-E2; and (2) if anti-E2 positivity pretransplantation protects against acquisition of GBV-C infection posttransplantation. Fifty-four recipients who underwent orthotopic liver transplantation for end-stage liver disease of nonviral etiologies were tested for GBV-C RNA using a PCR-based assay and anti-E2 antibodies by an enzyme-linked immunoassay. Anti-E2 was present in 35% and in 46% of patients pre- and posttransplantation, respectively. Anti-E2 positivity pretransplantation was strongly associated with anti-E2 positivity after transplantation (P < 0.001); 83% of patients with anti-E2 prior to transplantation remained anti-E2-positive after transplantation. A negative association between presence of GBV-C viremia and presence of anti-E2 was found in all patients tested either prior to or following transplantation (P=0.03). Acquisition of GBV-C infection was significantly lower in patients who were anti-E2-positive prior to transplantation (2/13) compared to those who were anti-E2-negative (12/26) (P=0.05). It is concluded that immunosuppression does not reduce the prevalence of anti-E2 after transplantation in those who are seroreactive prior to transplantation. Anti-E2 appears to be a neutralizing antibody whose presence at the time of liver transplantation protects against acquisition of GBV-C infection in the peritransplantation period.
Competency Management using the Competence Performance Approach (2007)

This chapter introduces a new approach in organizational Competency Management which is based on Korossy’s competence performance approach and which rests on the central idea of connecting competencies to actual job performance. Such an approach has several important benefits when compared to more traditional approaches. First, it brings competency modeling and assessment more closely to the actual work processes and tasks. Secondly, it makes possible validation of the models and the assessment within the modeling and assessment procedure. Finally, it is better able to cope with more dynamic and knowledge based settings. Three case studies in Engineering, Human Resource Management and Research and Development illustrate how the approach is introduced, evaluated and applied. The purpose of the chapter is to inform researchers in eLearning and Knowledge Management of how competencies can be used to support work integrated assessment and learning.
15-Deoxy-Δ12,14-prostaglandin J2 Induces Apoptosis of Human Hepatic Myofibroblasts (2001)

Hepatic myofibroblasts (hMFs) play a key role in the development of liver fibrosis associated with chronic liver diseases. Apoptosis of these cells is emerging as a key process in the resolution of liver fibrosis. Here, we examined the effects of cyclopentenone prostaglandins on apoptosis of human hMFs. Cyclopentenone prostaglandins of the J series markedly reduced hMF viability, with 15-deoxy-Delta(12,14)-prostaglandin J2 (15-d-PGJ2) being the most potent. This effect was independent of peroxisome-proliferator-activated receptors (PPARs), because PPARgamma and PPARalpha agonists did not affect hMF cell viability, and PPARgamma, the nuclear receptor for 15-d-PGJ2, was not expressed in hMFs. Moreover, 15-d-PGJ2 did not act via a cell surface G protein-coupled receptor, as shown in guanosine-5'-O-(3-thiotriphosphate) binding assays. Cell death resulted from an apoptotic process, because 15-d-PGJ2-treated hMFs exhibited condensed nuclei, fragmented DNA, and elevated caspase-3 activity. Moreover, the caspase inhibitor Z-Val-Ala-Asp(OCH3)-fluoromethyl ketone blocked the cytotoxic effect of 15-d-PGJ2. The apoptotic effects of 15-d-PGJ2 were reproduced by H2O2 and blocked by the antioxidants N-acetylcysteine (NAC), N-(2-mercapto-propionyl)-glycine (NMPG) and pyrrolidine dithiocarbamate (PDTC). Accordingly, 15-d-PGJ2 generated rapid production of reactive oxygen species in hMFs, via a NAC/NMPG/PDTC-sensitive pathway. In conclusion, 15-d-PGJ2 induces apoptosis of human hMFs via a novel mechanism involving oxidative stress and unrelated to activation of its nuclear receptor PPARgamma. These data underline the antifibrogenic potential of 15-d-PGJ2.
Application-Driven End-to-End Traffic Predictions for Low Power NoC Design (2012)

As chip multiprocessors keep increasing the number of cores on the chip, the network-on-chip (NoC) technology is becoming essential for interconnecting the cores. While NoCs result in noticeable performance boost over conventional bus systems, they consume a non-negligible fraction of the system power. One promising solution is to dynamically adjust the working frequencies/voltages of the switches as well as the links between switches in the NoC to match the traffic flows. The question is when to adjust and by how much. Most previous works take a passive approach by reacting to fluctuations in local traffic flows. Unfortunately, this approach may be too slow and too conservative in adjusting the working frequencies/voltages. Since applications often exhibit periodic behaviors, we propose a hardware mechanism to proactively adjust the frequencies/voltages of switches and/or links in NoC by predicting the application runtime traffic. The evaluations show that our design achieves 86% dynamic power savings of the links in the on-chip network, and the resulting overheads from mispredictions are tolerable.
The Retention of [<sup>99m</sup>Tc]-<i>d,l</i>-HM-PAO in the Human Brain after Intracarotid Bolus Injection: A Kinetic Analysis (1988)

[99mTc]-d,l-HM-PAO (HM-PAO) was injected rapidly into the internal carotid artery and its retention in the brain was recorded by external scintillation cameras in eight human subjects. A model is described based on three compartments: the lipophilic tracer in the blood pool of the brain, the lipophilic tracer inside the brain, and the hydrophilic form retained in the brain. The retention curve initially drops abruptly, corresponding to the nonextracted fraction of the injectate leaving the brain; it then falls exponentially towards the asymptotic level of the fractional steady-state retention R. Cerebral blood flow (F) was measured using the xenon-133 intracarotid injection method. The first-pass extraction E of HM-PAO was calculated from F using an empiric regression equation. The residue curves for the whole brain after intracarotid HM-PAO injection were analyzed to yield a retention fraction (R') and the brain clearance backflux constant of lipophilic HM-PAO (k). From the kinetic model and the measured values of R', k, and F, the following parameter values could be calculated: the average retained fraction of all tracer supplied to the brain, R = 0.38 +/- 0.05 (mean +/- SD), the conversion rate constant (lipophilic to hydrophilic tracer) in the brain k3 = 0.80 +/- 0.12 min-1, the efflux rate constant (brain to blood) k2 = 0.69 +/- 0.11 min-1, the conversion/clearance ratio alpha = k3/k2 = 1.18 +/- 0.25, the influx (blood clearance) constant K1 = 0.45 +/- 0.11 ml/g/min, and the brain/blood partition ratio lambda = K1/k2 = 0.67 +/- 0.23 ml/g. Using the kinetic model and assuming constancy of alpha, an algorithm was developed that corrects for the blood flow dependent backflux of HM-PAO and results in a more linear relation between regional cerebral blood flow (rCBF) and HM-PAO distribution.
Long-Term Interleukin-6 Levels and Subsequent Risk of Coronary Heart Disease: Two New Prospective Studies and a Systematic Review (2008)

Long-term IL-6 levels are associated with CHD risk about as strongly as are some major established risk factors, but causality remains uncertain. These findings highlight the potential relevance of IL-6-mediated pathways to CHD.
chemical and biological Weapons: current concepts for Future Defenses (2005)

In the post-9/11 era, the asymmetric threats posed by terrorists or rogue states have created new challenges for the enhanced and efficient defense of the nation. For defense against chemical and biological weapons (CBW), integrated, multitiered, and net-centric systems are envisioned that will enable the rapid and cost-effective detection, confirmation, and response to a CBW attack. Realization of this vision requires advances in the science and technology of chemical and biological sensor systems and multisource information fusion. Our evolving counter-CBW capability has broader benefits to society, where, for example, new tools will become available to manage outbreaks of emerging natural infectious diseases or industrial accidents. Here we highlight several key technologies and the challenges pursued in support of this vision.
Positive regulation of osteogenesis by bile acid through FXR (2013)

Searchable abstracts of presentations at key conferences on calcified tissues ISSN 2052-1219 (online)
A controlled clinical trial of a therapeutic bacteriophage preparation in chronic otitis due to antibiotic‐resistant <i>Pseudomonas aeruginosa</i>; a preliminary report of efficacy (2009)

The first controlled clinical trial of a therapeutic bacteriophage preparation showed efficacy and safety in chronic otitis because of chemo-resistant P. aeruginosa.
Calculation of Acousto-Optic Figure of Merit for Some of Oxide Crystals (2016)

In this paperwe present a method for calculating the acoustic velocity and acousto-optic figure of merit (AOFM). The AOFM as a function of material's refractive index, density, effective elasto-optic coefficient and the velocity of the acoustic wave in the material, are also investigated. By examining the directional dependent velocity, elasto-optic coefficients, and refractive index, the (AOFM) can be calculated and plotted in all directions revealing the optimal crystal orientation to maximize coupling between the optical and acoustic waves. We applied our method to four Oxide crystals such as (Lithium Niobate (LiNbO3), Lead Molybdate (PbMoO4),Titanium Dioxide (TiO2) and Zinc Oxide (ZnO)). The Wolfram Mathematica software are used to obtain the results. The results are shown that the AOFM is directional depend on acoustic wave propagation and Lead Molybdate (PbMoO4) have the highest figure of merit which is equal to [20.96910-15 (s3/Kg)] this value achieved in longitudinal acoustic wave propagation.
Kernel Principal Component Analysis for dimensionality reduction in fMRI-based diagnosis of ADHD (2012)

This study explored various feature extraction methods for use in automated diagnosis of Attention-Deficit Hyperactivity Disorder (ADHD) from functional Magnetic Resonance Image (fMRI) data. Each participant's data consisted of a resting state fMRI scan as well as phenotypic data (age, gender, handedness, IQ, and site of scanning) from the ADHD-200 dataset. We used machine learning techniques to produce support vector machine (SVM) classifiers that attempted to differentiate between (1) all ADHD patients vs. healthy controls and (2) ADHD combined (ADHD-c) type vs. ADHD inattentive (ADHD-i) type vs. controls. In different tests, we used only the phenotypic data, only the imaging data, or else both the phenotypic and imaging data. For feature extraction on fMRI data, we tested the Fast Fourier Transform (FFT), different variants of Principal Component Analysis (PCA), and combinations of FFT and PCA. PCA variants included PCA over time (PCA-t), PCA over space and time (PCA-st), and kernelized PCA (kPCA-st). Baseline chance accuracy was 64.2% produced by guessing healthy control (the majority class) for all participants. Using only phenotypic data produced 72.9% accuracy on two class diagnosis and 66.8% on three class diagnosis. Diagnosis using only imaging data did not perform as well as phenotypic-only approaches. Using both phenotypic and imaging data with combined FFT and kPCA-st feature extraction yielded accuracies of 76.0% on two class diagnosis and 68.6% on three class diagnosis-better than phenotypic-only approaches. Our results demonstrate the potential of using FFT and kPCA-st with resting-state fMRI data as well as phenotypic data for automated diagnosis of ADHD. These results are encouraging given known challenges of learning ADHD diagnostic classifiers using the ADHD-200 dataset (see Brown et al., 2012).
Cyclic GMP Metabolism and Involvement in Biological Regulation (1977)

The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous biological processes, including cell growth and fate decision, organ size ...Read More
Efficient Intramolecular Asymmetric Reductions of α-, β-, and γ-Keto Acids with Diisopinocampheylborane<sup>1</sup> (2000)

α-, β-, and γ-Keto acids are reduced with diisopinocampheylborane at room temperature to the corresponding hydroxy acids with predictable stereochemistry in very high ee. The γ-hydroxy acids produced were conveniently cyclized to the corresponding lactones. This provides a simple synthesis of 4-hexanolide, a component of the pheromone secreted by the female dermestid beetle Trogoderma glabrum.
Handbook of Data Structures and Applications (2004)

Although there are many advanced and specialized texts and handbooks on algorithms, until now there was no book that focused exclusively on the wide variety of data structures that have been reported in the literature. The Handbook of Data Structures and Applications responds to the needs of students, professionals, and researchers who need a mains