gebhart/patrepeval huggingface dataset:
Localization of radioiodinated antibody to alpha-fetoprotein in hepatoma transplanted in rats and a case report of alpha-fetoprotein antibody treatment of a hepatoma patient. (1980)

Abstract The localization of radioactive iodine-labeled anti-α-fetoprotein (AFP) antibody in transplanted rat hepatomas was examined by total body scintigraphy, subcellular distribution of radioactivity, and microautoradiography of tissues. The specific antibody was isolated from anti-rat AFP horse antiserum by immunoadsorbent that was coupled with rat AFP and radioiodinated with 125 I. F(ab′) 2 was isolated from peptic digests of the specific antibody. Normal horse IgG was taken as control. Scintigrams taken 48 to 168 hr after injection of the radiolabeled antibody or its F(ab′) 2 showed a remarkable localization in the tumors. Normal immunoglobulin G was also taken up in the tumor to some extent. The tumor/blood radioactivity ratio determined 7 days after the injection was about 4 times higher in the experimental group than was that in the control group, and the ratio on Day 7 was over 1.0. This indicated the active accumulation of the radiolabeled specific antibody in the tumor. Tumor tissues were homogenized and fractionated into subcellular fractions. About 30 to 60% of the total radioactivity in the homogenate was found in a fraction which contained cell membrane and nucleus. Microautoradiograms of the tissue sections showed the specific localization of radioactivity in the tumor but not in noncancerous tissues. Normal immunoglobulin G did not show significant localization in the tumor. These experimental results indicated the specific uptake of the radiolabeled antibody to AFP into AFP-producing tumor cells. A patient with an inoperable hepatoma was given 450 mg of purified anti-human AFP horse antibody i.v. Serum AFP level decreased in 2 days to the normal level (
Overexpression of BMI-1 Promotes Cell Growth and Resistance to Cisplatin Treatment in Osteosarcoma (2011)

These findings suggest a crucial role for BMI-1 in osteosarcoma pathogenesis.
Transforming growth factor-beta enhances the M-CSF and GM-CSF-stimulated proliferation of macrophages (1992)

Transforming growth factor-beta (TGF-beta) has been shown to regulate the proliferation and function of several different cell types in the immune system. We have examined the effect of TGF-beta on the proliferation of murine macrophages in liquid culture. TGF-beta by itself did not induce proliferation of differentiated (7 days in culture) bone marrow-derived macrophages (BMM). In the presence of M-CSF, TGF-beta enhanced the proliferation of differentiated BMM and elicited peritoneal macrophages but had an inhibitory effect on the proliferation of nonadherent BMM (3 days in culture). The effect of TGF-beta was not restricted to M-CSF-dependent proliferation but was also observed for GM-CSF-dependent proliferation. The autocrine production of TGF-beta appeared to contribute to the proliferation of BMM. The addition of antibody against TGF-beta inhibited M-CSF- and GM-CSF-dependent proliferation 32% and 28%, respectively. In bone marrow, TGF-beta may be an important negative regulator of macrophage proliferation; whereas, in the tissues, TGF-beta may enhance macrophage proliferation.
Average Inductor Current Sensor for Digitally Controlled Switched-Mode Power Supplies (2012)

Current-mode control in digitally controlled switched-mode power supplies typically requires analog-to-digital (A/D) conversion of at least two signals, voltage, and current. The complexity of voltage A/D converters can be reduced using window A/D techniques. In conventional current A/D conversion, however, relatively high resolution is required over a wide range of signals, which results in increased complexity, power consumption, and cost of the controller. This paper proposes a very simple feedback sensor capable of high-resolution average inductor current sensing using two analog comparators and an analog low-pass filter. The approach requires very few external components and employs minimal digital hardware resources. A dynamic model and performance of the average inductor current sensor are experimentally verified on a 12-V input, 19-V output, 50-W boost converter prototype. The applicability of the proposed sensor is demonstrated in a digitally controlled 400-W, 400-V output Boost power factor preregulator.
Effects of pentoxifylline on the hepatic content of TGF-β1 and collagen in Schistosomiasis japonica mice with liver fibrosis (2003)

High dose of PTX treatment could reduce the content of hepatic TGF-beta1, type I and type III collagen significantly in schistosomiasis japonica mice with liver fibrosis, and thus plays its role of antifibrosis.
Exploiting Endocytosis for Nanomedicines (2013)

In this article, we briefly review the endocytic pathways used by cells, pointing out their defining characteristics and highlighting physical limitations that may direct the internalization of nanoparticles to a subset of these pathways. A more detailed description of these pathways is presented in the literature. We then focus on the endocytosis of nanomedicines and present how various nanomaterial parameters impact these endocytic processes. This topic is an area of active research, motivated by the recognition that an improved understanding of how nanomaterials interact at the molecular, cellular, and whole-organism level will lead to the design of better nanomedicines in the future. Next, we briefly review some of the important nanomedicines already on the market or in clinical development that serve to exemplify how endocytosis can be exploited for medical benefit. Finally, we present some key unanswered questions and remaining challenges to be addressed by the field.
Evidence that Stable Retroviral Transduction and Cell Survival following DNA Integration Depend on Components of the Nonhomologous End Joining Repair Pathway (2004)

We have previously reported several lines of evidence that support a role for cellular DNA repair systems in completion of the retroviral DNA integration process. Failure to repair an intermediate in the process of integrating viral DNA into host DNA appears to trigger growth arrest or death of a large percentage of infected cells. Cellular proteins involved in the nonhomologous end joining (NHEJ) pathway (DNA-PK(CS)) and the damage-signaling kinases (ATM and ATR) have been implicated in this process. However, some studies have suggested that NHEJ proteins may not be required for the completion of lentiviral DNA integration. Here we provide additional evidence that NHEJ proteins are required for stable transduction by human immunodeficiency type 1 (HIV-1)-based vectors. Our analyses with two different reporters show that the number of stably transduced DNA-PK(CS)-deficient scid fibroblasts was reduced by 80 to 90% compared to the number of control cells. Furthermore, transduction efficiency can be restored to wild-type levels in scid cells that are complemented with a functional DNA-PK(CS) gene. The efficiency of stable transduction by an HIV-1-based vector is also reduced upon infection of Xrcc4 and ligase IV-deficient cells, implying a role for these components of the NHEJ repair pathway. Finally, we show that cells deficient in ligase IV are killed by infection with an integrase-competent but not an integrase-deficient HIV-1 vector. Results presented in this study lend further support to a general role for the NHEJ DNA repair pathway in completion of the retroviral DNA integration process.
Large-Scale Remote Sensing Image Retrieval Based on Semi-Supervised Adversarial Hashing (2019)

Remote sensing image retrieval (RSIR), a superior content organization technique, plays an important role in the remote sensing (RS) community. With the number of RS images increases explosively, not only the retrieval precision but also the retrieval efficiency is emphasized in the large-scale RSIR scenario. Therefore, the approximate nearest neighborhood (ANN) search attracts the researchers’ attention increasingly. In this paper, we propose a new hash learning method, named semi-supervised deep adversarial hashing (SDAH), to accomplish the ANN for the large-scale RSIR task. The assumption of our model is that the RS images have been represented by the proper visual features. First, a residual auto-encoder (RAE) is developed to generate the class variable and hash code. Second, two multi-layer networks are constructed to regularize the obtained latent vectors using the prior distribution. These two modules mentioned are integrated under the generator adversarial framework. Through the minimax learning, the class variable would be a one-hot-like vector while the hash code would be the binary-like vector. Finally, a specific hashing function is formulated to enhance the quality of the generated hash code. The effectiveness of the hash codes learned by our SDAH model was proved by the positive experimental results counted on three public RS image archives. Compared with the existing hash learning methods, the proposed method reaches improved performance.
Reactive path planning with collision avoidance in dynamic environments (2002)

We present an approach to path planning for remote surveillance robots in dynamic environments. The method has to increase robot autonomy. The problem is considered at two levels: using information from an a priori environment map, a path which avoids all the static obstacles is planned. Next, when following the path, the robot updates the map and adjusts the path with sensor information avoiding unexpected obstacles. The updating is done at quasi regular periods of time. We verify the efficiency of the method through simulation results.
Autoimmunity and Increased c- <i>myb</i> Transcription (1984)

A single recessive gene, lpr, induces an autoimmune-lymphoproliferative syndrome in several strains of mice. The lymphoid organs of lpr/lpr mice contained cells with increased amounts of myb RNA, which codes for a protein found in the nucleus. A similar human lymphoproliferative disorder also had an increase in c-myb expression. Mouse T cells induced by mitogens to proliferate did not express large amounts of myb RNA, indicating that marked myb expression is not a general feature of lymphocyte activation and proliferation.
<i>AtGA3ox2,</i> a Key Gene Responsible for Bioactive Gibberellin Biosynthesis, Is Regulated during Embryogenesis by <i>LEAFY COTYLEDON2</i> and <i>FUSCA3</i> in Arabidopsis (2004)

Embryonic regulators LEC2 (LEAFY COTYLEDON2) and FUS3 (FUSCA3) are involved in multiple aspects of Arabidopsis (Arabidopsis thaliana) seed development, including repression of leaf traits and premature germination and activation of seed storage protein genes. In this study, we show that gibberellin (GA) hormone biosynthesis is regulated by LEC2 and FUS3 pathways. The level of bioactive GAs is increased in immature seeds of lec2 and fus3 mutants relative to wild-type level. In addition, we show that the formation of ectopic trichome cells on lec2 and fus3 embryos is a GA-dependent process as in true leaves, suggesting that the GA pathway is misactivated in embryonic mutants. We next demonstrate that the GA-biosynthesis gene AtGA3ox2, which encodes the key enzyme AtGA3ox2 that catalyzes the conversion of inactive to bioactive GAs, is ectopically activated in embryos of the two mutants. Interestingly, both beta-glucuronidase reporter gene expression and in situ hybridization indicate that FUS3 represses AtGA3ox2 expression mainly in epidermal cells of embryo axis, which is distinct from AtGA3ox2 pattern at germination. Finally, we show that the FUS3 protein physically interacts with two RY elements (CATGCATG) present in the AtGA3ox2 promoter. This work suggests that GA biosynthesis is directly controlled by embryonic regulators during Arabidopsis embryonic development.
Sound Attenuation of Membranes Loaded with Square Frame-Shaped Masses (2016)

This study examines sound transmission of thin membranes with square frame-shaped masses. Numerical results indicate that multiple transmission loss peaks can be generated by adding more frame mass inclusions. The number and the location of the peaks are controlled by the number of frames, the frame distribution, and the frame width. Near the transmission loss peak frequencies, the dynamic effective mass density turns from positive to negative. The validity of the present model has been verified by comparing the analytical results with FE results. Two types of cell arrangements are also considered in this study, namely, cells in series and cells in array. It is seen that either the stacked or array configurations can produce better sound attenuation than single-celled structures. Moreover, the frequency band where sound wave is blocked can be broadened by stacking more layers with different mass magnitudes. Furthermore, additional frequency bands due to the periodicity of the structure are found in the stacked configurations.
The Cold Fusion: Web Application Construction Kit: Second Edition (1998)

From the Publisher:
An all-in-one kit that gives you everything you need to create Web-based applications including the latest version of the Cold Fusion. Create dynamic, data-driven Web sites without programming. Learn how to use Cold Fusion Studio, the new interactive Cold Fusion development environment, and all of it's Wizards. Learn how to implement credit card verification and authorization. Learn Cold Fusion s Java-based form technology to enhance your applications and databases.
An all-in-one kit that gives you everything you need to create Web-based applications including the latest version of the Cold Fusion
Create dynamic, data-driven Web sites without programming
Learn how to use Cold Fusion Studio, the new interactive Cold Fusion development environment, and all of it's Wizards
Observation of Radially Localized Atomic Electron Wave Packets (1988)

We have observed a radially localized electron wave packet in a direct pump-probe experiment with 6-ps laser pulses. Use is made of the fact that both excitation and ionization take place predominantly close to the atomic core. A wave packet is created by coherently exciting Rydberg states of rubidium atoms around $n=41$ with a pump pulse, and detected through ionization with a delayed probe pulse. The wave packet is observed to return to the core twice before the spreading becomes too large.
Asynchronous Transfer Mode Switching LSI Chips with 10-Gb/s Serial I/O Ports (1995)

LSI chips were developed that fit on a switching fabric using chip-to-chip optical interconnections; they have 10-Gb/s serial input and output ports, which facilitates the layout of optically interfaced switching element modules. A test switching module composed of these chips was operated at 10.2 Gb/s without bit errors. Ultrahigh-speed switching LSI chips have been developed for a future asynchronous transfer mode (ATM) switching system with an over-Tb/s capacity. Their serial input and output ports facilitate chip-to-chip optical interconnection. Cell-dropper and crosspoint-router LSI chips, composing the core of the switching element, were fabricated by using GaAs LSI technology. A test switching module composed of these chips was operated at 10.2 Gb/s without bit errors
Free Boundary Problems in Controlled Release Pharmaceuticals: II. Swelling-Controlled Release (1988)

A problem in controlled release pharmaceutical systems is formulated and studied. The device modeled is a polymer matrix containing an initially immobilized drug. The release of the drug is achieved by countercurrent diffusion through a penetrant solvent with the release rate being determined by the rate of diffusion of the solvent in the polymer. The mathematical theory yields a free boundary problem which is studied in various asymptotic regimes.
A switched Hall IC for automotive electronic applications (2009)

This paper presents a design of a switched Hall IC, which can operate in automotive electronic applications with wide range of voltage and temperature from 3.8 V to 30 V and -40°C to +150°C, respectively. Besides, for a hysteretic comparator is contained in the signal processing circuit, it can be used with hysteretic loop-line width of 0.456 V and with trigger and release magnetic field of 14.5 mT and 11.5 mT, respectively. The whole design are simulated and verified by 4 um bipolar technology, and the simulation results prove the validity of our design.
Role of vasopressin in current anesthetic practice (2017)

Arginine vasopressin (AVP), also known as antidiuretic hormone, is a peptide endogenously secreted by the posterior pituitary in response to hyperosmolar plasma or systemic hypoperfusion states. When administered intravenously, it causes an intense peripheral vasoconstriction through stimulation of V<sub>1</sub> receptors on the vascular smooth muscle. Patients in refractory shock associated with severe sepsis, cardiogenic or vasodilatory shock, or cardiopulmonary bypass have inappropriately low plasma levels of AVP ('relative vasopressin deficiency') and supersensitivity to exogenously-administered AVP. Low doses of AVP and its synthetic analog terlipressin can restore vasomotor tone in conditions that are resistant to catecholamines, with preservation of renal blood flow and urine output. They are also useful in the treatment of refractory arterial hypotension in patients chronically treated with renin-angiotensin system inhibitors, cardiac arrest, or bleeding esophageal varices. In the perioperative setting, they represent attractive adjunct vasopressors in advanced shock states that are unresponsive to conventional therapeutic strategies.
Fermentation equations for propionic‐acid bacteria and production of assorted oxychemicals from various sugars (1985)

Fermentation (stoichiometric) equations are derived for anaerobic fermentations of propionic-acid bacteria (of both the Propionibacterium and acrylate pathways) and for production of various oxychemicals (butanol, acetone, isopropanol, butanediol, butyrate, acetate, propionate, succinate, lactate, and acrylate) from pentoses, hexoses, and cellobiose. The derivations of the equations are based on the fermentation biochemistries of the various bacterial classes. The validity of the equations is tested using fermentation data from the literature. The equations are shown to be valuable, among other uses, for calculating maximal yields and selectivities of the various fermentation products, as "gateway sensors" for monitoring of the fermentations, and for calculating the extents of the various intracellular reactions of the fermentation biochemistry.
Data Mining and Service Rating in Service-Oriented Architectures to Improve Information Sharing (2005)

The evolution of Web services and service oriented architectures (SOA) has enabled removal of many technological barriers that have historically limited information sharing across the United States intelligence community (IC). During the past decade, Internet and Web technologies have facilitated the exponential growth of data and information available creating information overload and forcing the need for tools to manage information. Just as the Internet brought about information overload, the growth in development and deployment of services will lead to service overload in the coming decade. To address the challenge, this paper proposes an extended SOA infrastructure to facilitate service discovery and automate service orchestration by using data mining and service rating technologies. Data mining, the process of extracting patterns and knowledge hidden from large volumes of raw data, includes techniques such as classification, clustering, association rules, and sequential patterns. Service rating, on the other hand, involves techniques of capturing and incorporating user review and ratings on service performance, effectiveness, and reliability. By applying these technologies to an analytical environment within the IC, this paper demonstrates how they can help with service categorization, service discovery, automated service composition and construction of dynamic communities of interest (COIs), which empowers analysts to collaboratively solve complex problems
Foot-and-Mouth Disease Virus, but Not Bovine Enterovirus, Targets the Host Cell Cytoskeleton via the Nonstructural Protein 3C <sup>pro</sup> (2008)

Foot-and-mouth disease virus (FMDV), a member of the Picornaviridae, is a pathogen of cloven-hoofed animals and causes a disease of major economic importance. Picornavirus-infected cells show changes in cell morphology and rearrangement of cytoplasmic membranes, which are a consequence of virus replication. We show here, by confocal immunofluorescence and electron microscopy, that the changes in morphology of FMDV-infected cells involve changes in the distribution of microtubule and intermediate filament components during infection. Despite the continued presence of centrosomes in infected cells, there is a loss of tethering of microtubules to the microtubule organizing center (MTOC) region. Loss of labeling for gamma-tubulin, but not pericentrin, from the MTOC suggests a targeting of gamma-tubulin (or associated proteins) rather than a total breakdown in MTOC structure. The identity of the FMDV protein(s) responsible was determined by the expression of individual viral nonstructural proteins and their precursors in uninfected cells. We report that the only viral nonstructural protein able to reproduce the loss of gamma-tubulin from the MTOC and the loss of integrity of the microtubule system is FMDV 3C(pro). In contrast, infection of cells with another picornavirus, bovine enterovirus, did not affect gamma-tubulin distribution, and the microtubule network remained relatively unaffected.
Candida biofilms in medical devices: evolving trends. (2008)

he study of microorganisms since ages has been associated with their isolation and growth in pure culture and their subsequent identification down to their genes. This channel of study has been actively pursued in various scientific disciplines pertaining to anatomical, physiological and pathological aspects of microbes and the scientific research that is based on them. However, many microbes in their natural habitats are found in biofilm ecosystems
In vivo induction of antigen-specific transplantation tolerance to Qa1a by exposure to alloantigen in the absence of T-cell help. (1990)

A goal of transplantation immunology is to be able to induce antigen-specific tolerance in transplant recipients. In the present study we describe an in vivo model of antigen-specific transplantation tolerance to skin allografts using mice congenic at Qa1, a ubiquitously expressed class I-like molecule encoded to the right of H-2D. B6 mice are deficient in Qa1a-specific T-helper cells and only reject Qa1a disparate tail skin grafts when a second graft expressing additional helper determinants is also present. We report that animals initially engrafted with Qa1a disparate skin, in the absence of any source of additional help, are rendered tolerant to Qa1a disparate skin allografts despite the subsequent presence of inducer skin grafts expressing additional helper allodeterminants. The nonresponsive state is Qa1a-specific, because HY-bearing inducer grafts are rejected normally. In vitro, Qa1a-tolerant animals are specifically unable to generate anti-Qa1a T-killer cells, which provides the cellular basis for their failure in vivo to reject Qa1a skin allografts. Thus, initial exposure to Qa1a allodeterminants, in the absence of T-cell help, leads to a state of Qa1a-specific transplantation tolerance. This study suggests that antigen-specific transplantation tolerance may be induced by exposing naive T-killer cells to tissue alloantigens under conditions in which T-cell help is not generated.