gebhart/patrepeval huggingface dataset:
Identification of piRNAs in Hela cells by massive parallel sequencing (2010)

Piwi proteins and Piwi-interacting RNAs (piRNAs) have been implicated in transposon control in germline from Drosophila to mammals. To examine the profile of small RNA expression in human cancer cells and explore difference in small RNA transcriptome, small RNA libraries prepared from wildtype, HILI overexpressed and HILI knockdowned Hela cells were sequenced using Solexa technology. piRNAs and other repeat- associated small RNAs were observed in Hela cells. By using in situ hybridization, piR-49322 was localized in the nucleolus and around the periphery of nuclear membrane in Hela cells. Following the overexpression of HILI, the retrotransposon elements LINE1 was significantly repressed, while LINE1-associated small RNAs decreased in abundance. The present study demonstrated that HILI along with piRNAs plays a role in LINE1 suppression in Hela cancer cell line.
Cell proliferation and invasion in malignant gliomas. (1997)

Cell proliferation and invasion were studied in sixty biopsies of malignant gliomas selected to reproduce the spreading modalities identified in ninety autopsy cases of glioblastoma. Cell proliferation was studied by the immunohistochemical demonstration of PCNA and MIB-1 and by the calculation of their labeling indexes (LI). The main finding was that cell proliferation and cell invasion are not necessarily associated. The interface between the solid tumor and the adjacent brain was represented either by a gradient of tumor cell density or by a clearcut demarcation of the tumor. In the first case the LI either did not change in the infiltration area in comparison with solid tumor or it was much lower, whereas in the second case there was a ring with a high density of labeled nuclei at the tumor periphery. Perineuronal satellites were usually positive for proliferation markers. Cells accumulated in the outer cortical layers, from a deeply located tumor, were almost negative, whereas those originating from subarachnoidal or subpial invasion showed a high LI. High LIs were also found in subarachnoidal and subpial growths, and in a cell population descending into the brain parenchyma around meningeal penetrating vessels. The relationship between cell proliferation and invasion from in vivo studies is not a direct and a simple one.
Assessing Strategic Effects of Artificial Intelligence (2018)

This workshop examines the implications of advances in artificial intelligence (AI) on international security, discussing the question of whether we will have to rethink, by the end of the next decade, how we practice nuclear deterrence and ensure strategic stability. Hosted by the Center for Global Security Research (CGSR) at Lawrence Livermore National Laboratory (LLNL), the workshop is part of a collaboration between CGSR and Technology for Global Security (T4GS) to engage policy-makers, scholars, technical experts, and the private sector to address emerging challenges in AI and related issues. The workshop engages with the current literature pointing to the risks and opportunities presented by AI and attempts to assess which are legitimate and which might be exaggerated.
Object-oriented design of preconditioned iterative methods in diffpack (1997)

As modern programming methodologies migrate from computer science to scientific computing, developers of numerical software are faced with new possibilities and challenges. Based on experiences from an ongoing project that develops C software for the solution of partial differential equations, this article has its focus on object-oriented design of iterative solvers for linear systems of equations. Special attention is paid to possible conflicts that have to be resolved in order to achieve a very flexible, yet efficient, code.
Beyond Metaphors: New Research on Agendas in the Policy Process<sup>1</sup> (2011)

Research on agenda setting seems to have arrived at a second stage in its development. In recent years, it has moved beyond both metaphors and popular units of analysis to study the mechanisms and dynamics of agenda setting in the public policy process. This essay synthesizes the last two years of research on agenda setting. It classifies the divergent work into three broad categories. The first focuses on information processing and punctuated equilibrium processes. The second addresses the attempts by scholars to move beyond subsystems as a unit of analysis. The third addresses the role of the bureaucracy in agenda setting, particularly during crises. The final section of the essay concludes by discussing future directions for research.
PP.30.06 (2015)

Objective: Shisha or water pipe smoking is becoming popular as a way of tobacco use in the world. This study was designed to evaluate the acute effects of shisha smoking on blood pressure (BP) and heart rate (HR) in healthy adults. Design and method: The study was carried out in 6 restaurants where shisha could be smoked. Individuals who ordered shisha were identified and were consented to enroll in the study (shisha group). Controls consisted of subjects who were sitting on the same table of shisha smokers but who did not smoke shisha (passive smokers group) and of subjects who were sitting in non-smoking sections of the restaurant far away from shisha smokers (non-smokers group). Subjects who smoked shisha within the previous 12 hours or any cigarette within the previous 1 hour, and those with known ischemic cardiovascular disease were excluded. BP and HR were measured with an automated sphygmomanometer immediately before and 15 minutes after smoking shisha, or at baseline and 15 minutes later in controls. Results: 194 subjects were enrolled: 101 shisha smokers, 51 passive smokers and 42 non-smokers. There were no differences in age, body mass index and the prevalence of diabetes mellitus or hyperlipidemia between the 3 groups. Shisha smokers however, were more commonly males (65% vs. 49% and 45%; p = 0.04); passive smokers had more frequently a history of hypertension (22% vs. 9% for shisha smokers and 5% for non-smokers; p = 0.02). Cigarette smoking tended to be more common in the shisha and passive smokers groups (24% and 22% vs. 7% in non-smokers; p = 0.07). Systolic and diastolic BP and HR significantly increased after 15 minutes of smoking in the shisha group but did not change significantly in the 2 other groups (table). Oxygen saturation did not change in any of the groups (98% at baseline and at 15 minutes).Conclusions: Shisha smoking for duration as short as 15 minutes has acute hemodynamic effects and significantly increases systolic and diastolic BP and HR. Whether chronic shisha smoking can result in sustained hypertension requires further investigations.
Endovascular aneurysm repair with fascia suture technique: short and mid-term results. (2016)

The FST seems safe and effective for femoral reconstruction after p-EVAR. Complications are comparable to closure devices and to conventional repair.
Characterization of thin, doped silicon single crystals by x-ray diffraction (1992)

A free-standing, extremely thin silicon membrane, prepared by chemical vapor deposition of an epitaxial layer and subsequent anisotropic, selective etching, has been studied. The epitaxial layer consisted of a sandwich structure of undoped and highly boron/germanium-doped films, serving as an etch stop. The results of double- and triple-crystal x-ray diffractometry in the Bragg and Laue case, i.e., in reflection and transmission, respectively, are reported using x radiation between 8.05 (Cu Kα1) and 17.5 keV (Mo Kα1) photon energy. The thickness of the crystal was determined to z0=(30±1) μm and its curvature to &lt;7×10−4 m−1. The influence of the doped etch stop layer on the x-ray reflectivity is discussed in detail.
An Examination of Multivariate Time Series Hashing with Applications to Health Care (2014)

As large-scale multivariate time series data become increasingly common in application domains, such as health care and traffic analysis, researchers are challenged to build efficient tools to analyze it and provide useful insights. Similarity search, as a basic operator for many machine learning and data mining algorithms, has been extensively studied before, leading to several efficient solutions. However, similarity search for multivariate time series data is intrinsically challenging because (1) there is no conclusive agreement on what is a good similarity metric for multivariate time series data and (2) calculating similarity scores between two time series is often computationally expensive. In this paper, we address this problem by applying a generalized hashing framework, namely kernelized locality sensitive hashing, to accelerate time series similarity search with a series of representative similarity metrics. Experiment results on three large-scale clinical data sets demonstrate the effectiveness of the proposed approach.
Sams Teach Yourself Visual C++.NET in 21 Days (1998)

From the Publisher:

Sams Teach Yourself Visual C++.NET in 21 Days, 2nd Edition is a time-saving guide walking you through Visual C++ tools and wizards for building applications and places VC++ in the context of the new Visual Studio.NET environment. This book emphasizes using Visual C++ tools and wizards to generate code. Code examples are augmented with C++ language sidebars: Readers who need a refresher on the language or want to go further under the hood will have a context, while those who don't can easily skip that coverage. The revision includes more information throughout on Microsoft Foundation Classes (MFC), how Windows applications work, and how MFC abstracts the Windows functionality to simplify building applications. Chapters on managed code, ATL functionality, and interacting with VB and C# components will help users begin to master the new .NET aspects of Visual C++.
Piezoelectric paints as one approach to smart structural materials with health-monitoring capabilities (1998)

Piezoelectric paints have a potential to change a conventional structural material into an intelligent material system with health-monitoring capabilities such as vibration sensing and damage detection. Such paints were prepared using lead zirconate titanate (PZT) ceramic powder as a pigment and epoxy resin as a binder. The obtained paints were coated on aluminum test specimens, and were cured at room temperature or at 150 , thus forming the paint films having different thicknesses of 25-300 . These films were then poled at room temperature, and were evaluated with regard to the sensitivities as vibration and acoustic emission sensors in the frequency ranges of 0-250 Hz and 0-1.0 MHz, respectively. This paper mainly describes the effects of the film thickness and the cure temperature on the poling behavior of the PZT/epoxy paint film. This paper describes also the application of the paint film as a vibration modal sensor integrated into a structural material.
Wavelength division multiplexed transmission over standard single mode fiber using polarization insensitive signal conjugation in highly nonlinear optical fiber (2003)

We demonstrate 10 Gb/s, 5-channel, wavelength multiplexed transmission over four 80-km standard fiber spans using polarization invariant spectral inversion provided by a broadband fiber parametric amplifier using orthogonally-polarized pumps having synchronized phase modulation for stimulated Brillouin suppression.
Caching intermediate results for program improvement (1995)

Article Free Access Share on Caching intermediate results for program improvement Authors: Yanhong A. Liu Department of Computer Science, Cornell University, Ithaca, NY Department of Computer Science, Cornell University, Ithaca, NYView Profile , Tim Teitelbaum Department of Computer Science, Cornell University, Ithaca, NY Department of Computer Science, Cornell University, Ithaca, NYView Profile Authors Info & Claims PEPM '95: Proceedings of the 1995 ACM SIGPLAN symposium on Partial evaluation and semantics-based program manipulationJune 1995 Pages 190–201https://doi.org/10.1145/215465.215590Published:23 June 1995Publication History 17citation464DownloadsMetricsTotal Citations17Total Downloads464Last 12 Months12Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Distal Femur as a Donor Site of Autogenous Cancellous Bone Graft (1995)

We performed a prospective clinical study and a cadaveric study to evaluate the morbidity associated with harvesting cancellous bone from the distal femoral metaphysis for use in the lower extremity. Thirty patients underwent harvest of distal femoral cancellous bone: 13 for acute trauma and 17 for reconstructive procedures. The distal femoral condyle is approached through a 6-cm midlateral, longitudinal incision. A small cortical window is created, bone graft is harvested, and the cortical window is replaced. All patients were kept nonweight bearing on the extremity for a minimum of 6 weeks. Patients were followed for an average of 10 months (range 3-32 months) and no patient was lost to follow-up before allowing full weight bearing. There were no donor site would or neurovascular problems and no femur fractures. A cadaveric study was also performed in which bone was harvested from the distal femur, the bone was quantified, and the knees were tested in compression (axial loading). The bone-harvested knees failed in the same load range as the contralateral control knees did. The distal femoral metaphysis has many advantages compared with the iliac crest in cases when cancellous bone is needed for the lower extremity. Harvesting distal femoral bone is associated with little morbidity if performed correctly, and if the patient remains nonweight bearing for 6 weeks.
Isolation of a cDNA encoding the largest subunit of TFIIA reveals functions important for activated transcription. (1993)

Transcription factor IIA has been shown to interact with the TATA-binding protein and to act early during preinitiation complex formation. The human factor is composed of three subunits (alpha, beta, gamma). A human cDNA clone encoding the largest subunit of TFIIA (alpha) was isolated. The recombinant alpha polypeptide, together with the beta and gamma subunits, was capable of reconstituting TFIIA activity. Studies using antibodies raised against recombinant alpha polypeptide demonstrate that TFIIA can be an integral component of the preinitiation complex. We demonstrate that TFIIA not only interacts with TBP but also can associate with the TFIID complex. Functional assays establish that TFIIA has no apparent role in basal transcription but plays an important role in activation of transcription. Interestingly, amino acid sequence analyses of the beta-subunit demonstrate these residues to be entirely contained within the carboxyl terminus of the cDNA clone encoding the alpha-subunit.
Beyond Interoperability - Pushing the Performance of Sensor Network IP Stacks (2011)

Interoperability is essential for the commercial adoption of wireless sensor networks. However, existing sensor network architectures have been developed in isolation and thus interoperability has not been a concern. Recently, IP has been proposedas a solutionto the interoperabilityproblem of low-power and lossy networks (LLNs), considering its open and standards-based architecture at the network, transport, and application layers. We present two complete and interoperable implementations of the IPv6 protocol stack for LLNs, one for Contiki and one for TinyOS, and show that the cost of interoperability is low: their performance and overhead is on par with state-of-the-art protocol stacks custom built for the two platforms. At the same time, extensive testbed results show that the ensemble performance of a mixed network with nodes running the two interoperable stacks depends heavily on implementation decisions and parameters set at multiple protocol layers. In turn, these results argue that the current industry practice of interoperability testing does not cover the crucial topic of the performance and motivate the need for generic techniques that quantify the performance of such networks and configure their runtime behavior.
A hypertext system for literate C++ programming (1992)

Programs are written to be executed by computers rather than to be read by humans. This complicates program comprehension, which plays a major role in software maintenance. Literate programming is an approach to improve program understanding by regarding programs as works of literature (see [Knu84]). In this paper we present a tool that supports literate programming with the objectoriented programming language C++. The tool is based on a hypertext system which has been developed to support program comprehension and, thus, software maintenance. An introduction of the basic hypertext system is followed by a presentation of the global structure of the documentation. Afterwards, the user interface of the tool, its use and a sample documentation are given. Some implementation aspects conclude the presentation. Introduction Development programmers hate documentation which, therefore, almost never is either complete or consistent. Maintenance programmers need documentation to understand t...
Studying how character of conversation affects personal receptivity to mobile notifications (2014)

In this paper we promote the idea of analyzing the character of a conversation that the user is engaged in to help determine her receptivity to mobile notifications. Given that most previous mobile notification management systems incorporate only general awareness of speech or just consider the mere presence of the user's voice, we argue for the use of speaker tracking to completely capture presence as well as dynamics and other characteristics of personal conversations in order to assess personal interruptibility.
A new method for determining gastric acid output using a wireless <scp>pH</scp>‐sensing capsule (2013)

SP GAO analysis is a non-invasive, accurate and reproducible method for the quantitative measurement of GAO in healthy subjects. SP GAO analysis could facilitate research and clinical management of GERD and other disorders of gastric acid secretion.
Structural organization, expression, and functional characterization of the murine cytomegalovirus immediate-early gene 3 (1992)

We have previously defined ie3 as a coding region located downstream of the ie1 gene which gives rise to a 2.75-kb immediate-early (IE) transcript. Here we describe the structural organization of the ie3 gene, the amino acid sequence of the gene product, and some of the functional properties of the protein. The 2.75-kb ie3 mRNA is generated by splicing and is composed of four exons. The first three exons, of 300, 111, and 191 nucleotides (nt), are shared with the ie1 mRNA and are spliced to exon 5, which is located downstream of the fourth exon used by the ie1 mRNA. Exon 5 starts 28 nt downstream of the 3' end of the ie1 mRNA and has a length of 1,701 nt. The IE3 protein contains 611 amino acids, the first 99 of which are shared with the ie1 product pp89. The IE3 protein expressed at IE times has a relative mobility of 88 kDa in gels, and a mobility shift to 90 kDa during the early phase is indicative of posttranslational modification. Sequence comparison reveals significant homology of the exon 5-encoded amino acid sequence with the respective sequence of UL 122, a component of the IE1-IE2 complex of human cytomegalovirus (HCMV). This homology is also apparent at the functional level. The IE3 protein is a strong transcriptional activator of the murine cytomegalovirus (MCMV) e1 promoter and shows an autoregulatory function by repression of the MCMV ie1/ie3 promoter. The high degree of conservation between the MCMV ie3 and HCMV IE2 genes and their products with regard to gene structure, amino acid sequence, and protein functions suggests that these genes play a comparable role in the transcriptional control of the two cytomegaloviruses.
Book Reviews (1993)

Book Reviews Get access The West German Economy, 1945–1955. By ALAN KRAMER (Oxford: Berg, 1991; pp. xiii + 295. £29.50); The Fruits of Fascism. Postwar Prosperity in Historical Perspective. By SIMON REICH (Ithaca/London: Cornell U.P., 1990; pp. xii + 341. $46.50; pb.$15.95). R. J. OVERY R. J. OVERY King's CollegeLondon Search for other works by this author on: Oxford Academic Google Scholar The English Historical Review, Volume CVIII, Issue 428, July 1993, Pages 689–691, https://doi.org/10.1093/ehr/CVIII.428.689 Published: 01 July 1993
Cangrelor (2015)

Each month, subscribers to <i>The Formulary Monograph Service</i> receive 5 to 6 well-documented monographs on drugs that are newly released or are in late phase 3 trials. The monographs are targeted to Pharmacy & Therapeutics Committees. Subscribers also receive monthly 1-page summary monographs on agents that are useful for agendas and pharmacy/nursing in-services. A comprehensive target drug utilization evaluation/medication use evaluation (DUE/MUE) is also provided each month. With a subscription, the monographs are sent in print and are also available on-line. Monographs can be customized to meet the needs of a facility. A drug class review is now published monthly with <i>The Formulary Monograph Service.</i> Through the cooperation of <i>The Formulary, Hospital Pharmacy</i> publishes selected reviews in this column. For more information about <i>The Formulary Monograph Service</i>, call <i>The Formulary</i> at 800-322-4349. The November 2015 monograph topics are evolocumab, dichlorphenamide, necitumumab, cobimetinib, and reslizumab. The Safety MUE is on alirocumab and evolocumab.
THREE-DIMENSIONAL SOUND FIELD REPRODUCTION AND RECORDING SYSTEMS BASED ON BOUNDARY SURFACE CONTROL PRINCIPLE (2008)

Based on the boundary surface control (BSC) principle, a new recording/reproduction system is developed to realize high fidelity three-dimensional sound field reproduction. Theoretically, using this new system, perfect sound field reproduction can be achieved in any acoustic environment. Sound recording / reproduction systems based on the BSC principle require many loudspeakers and microphones. In the new system, the microphone array system that is used to record the 3D sound field consists of 70 microphones, and the loudspeaker system to reproduce the recorded 3D sound field consists of 62 full-range units and eight sub-woofer units. This paper describes the composition of the new recording/ reproduction system and evaluates its ability by means of sound localization tests with nine subjects. Results of experiments show that a clear sound image in the horizontal plane is reconstructed using the proposed system. 1.