gebhart/patrepeval huggingface dataset:
Clinical research of Naloxone on treatment of neonatal hypoxic-ischemic encephalopathy (32 cases report) (2010)

Objective To observe the efficacy of Naloxone on treatment of neonatal hypoxic-ischemic encephalopathy. Methods Clinical datas of 64 newborns with hypoxic-ischemic encephalopathy were collected and analyzed retrospectively from August 2005 and October 2008. Sixty-four cases were randomly divided into 2 groups: treatment group and control group (32 cases each). Supporting and symptomactic treatment were given to both groups. Naloxone was given to treatment group, 3-5 days each course of treatment. Efficacy and drug side effect were observed.Results Nineteen cases (59.4%) were excellence, 10 cases (31.3%) were utility, 3 cases (9.4%) were inefficacy, and the total effective rate was 90.7% in treatment group. 11 cases (34.4%) were excellence, 13 cases (40.6%) were utility, 8 cases (25%) were inefficacy, and the total effective rate was 75% in control group. There are statistic different between two groups (P＜0.05).Conclusions Naloxone has the benefit to improve clinical manifestation, raise cure rate on treatment of neonatal hypoxic-ischemic encephalopathy. It is worthy to apply in clinical treatment with no drug side effect, safety and economy.

Key words: 
Newborn ;  Hypoxic-ischemic encephalopathy ;  Naloxone ;  Efficacy ;
Active isolator, combiner, divider, and magic-T as miniaturized function blocks (2003)

Describes a realization of miniaturized and broadband function blocks for highly integrated monolithic microwave circuits, where simplicity of the circuit's configuration is one of the most important factors. The authors describe the design approach and results achieved with recently developed line unified FETs (LUFETs) and the active matching technique applied to active isolator, combiner, divider, and magic-T (180 degrees hybrid) function blocks operating from 1 GHz to 10 GHz or higher.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Multimegawatt cyclotron autoresonance accelerator (1996)

Means are discussed for generation of high-quality multimegawatt gyrating electron beams using rf gyroresonant acceleration. TE111-mode cylindrical cavities in a uniform axial magnetic field have been employed for beam acceleration since 1968; such beams have more recently been employed for generation of radiation at harmonics of the gyration frequency. Use of a TE11-mode waveguide for acceleration, rather than a cavity, is discussed. It is shown that the applied magnetic field and group velocity axial tapers allow resonance to be maintained along a waveguide, but that this is impractical in a cavity. In consequence, a waveguide cyclotron autoresonance accelerator (CARA) can operate with near-100% efficiency in power transfer from rf source to beam, while cavity accelerators will, in practice, have efficiency values limited to about 40%. CARA experiments are described in which an injected beam of up to 25 A, 95 kV has had up to 7.2 MW of rf power added, with efficiencies of up to 96%. Such levels of efficiency are higher than observed previously in any fast-wave interaction, and are competitive with efficiency values in industrial linear accelerators. Scaling arguments suggest that good quality gyrating megavolt beams with peak and average powers of 100 MW and 100 kW can be produced using an advanced CARA, with applications in the generation of high-power microwaves and for possible remediation of flue gas pollutants.
Design, Optimization and Evaluation of a Dual-Radius Spherical Microphone Array (2013)

Spherical Microphone Arrays (SMAs) constitute a powerful tool for analyzing the spatial properties of sound fields. However, the performance of SMA-based signal processing algorithms ultimately depends on the physical characteristics of the array. In particular, the range of frequencies over which an SMA provide rich spatial information is conditioned by the size of the array, the angular position of the sensors and other factors. In this work, we investigate the design of SMAs offering a wider frequency range of operation than that offered by conventional designs. To achieve this goal, microphones are distributed both on and at a distance from the surface of a rigid spherical baffle. The contributions of the paper are as follows. First, we present a general framework for modeling SMAs whose sensors are located at different distances from the array center and calculating optimal filters for the decomposition of the sound field into spherical harmonic modes. Second, we present an optimization method to design multi-radius SMAs with an optimally wide frequency range of operation given the total number of sensors available and target spatial resolution. Lastly, based on the optimization results, we built a prototype dual-radius SMA with 64 microphones. We present measurement results for the prototype microphone array and compare these results with theory.
Colorless, Transparent, Aromatic Polyimide Films (1986)

New process yields aromatic condensation polyimide films essentially colorless. Films between 90- and 100-percent transparent at visible wavelength of 500 nm. Optically transparent polyimide films made from variety of aromatic condensation polyimides. Range from very pale in color to colorless, compared to bright yellow color of conventional/ commercial aromatic polyimide film. Increased transparency achieved at no sacrifice in thermal stability, flexibility, toughness, or mechanical properties. These features extremely attractive as films or coating materials for aerospace applications or for any other applications where high optical transparency or thermal stability is required.
Software project process management maturity and project performance: An examination of Taiwan's software companies (2002)

Researchers and practitioners argue that an inadequate software development process is one critical factor accounting for high project failure rates. a result, the Capability Maturity Model (CMM) was introduced by the Software Engineering Institute as a guideline for advancing project maturity and improving the odds of project success. To investigate the effectiveness of applying the principles of the CMM, a survey was conducted of 196 Information System managers in Taiwan. The results indicate that a more mature software development process reduces the extent of certain risks experienced during the project development and enables better project performance. Managerial implications regarding the CMM are described.
Cylinder To Cylinder AFR Control With An Asymmetrical Exhaust Manifold in a GDI System (1998)

<div class="htmlview paragraph">In this work we have developed an algorithm to estimate and control the air fuel ratio of each cylinder from the measurement of an UEGO sensor placed at the confluence point in the exhaust manifold.</div> <div class="htmlview paragraph">In our case of study the exhaust manifold was very asymmetric.</div> <div class="htmlview paragraph">We have developed a simple model of this exhaust manifold capable of satisfying the control objectives.</div> <div class="htmlview paragraph">The lambda value for each cylinder is predicted from the actual lambda value measured at the confluence point by 4 different static Kalman filters depending on the cylinder that has finished its exhaust phase.</div> <div class="htmlview paragraph">The lambda feedback uses the output of the Kalman filters to control the AFR for each cylinder.</div> <div class="htmlview paragraph">The algorithm has been implemented on a production SAGEM ECU and the experimental tests have been made on a PSA 1.8 liter 4 cylinder engine</div> <div class="htmlview paragraph">The experimental results show that the algorithm is able to correct the cylinder to cylinder AFR with an accuracy around 3% for a fueling variation of 30%.</div> <div class="htmlview paragraph">This strategy is therefore useful mainly in the case of direct injection for very lean and stratified combustion, or in classical MPI systems.</div>
ASPECTS OF THE DEVELOPMENT OF THE PREFECTURE OF ELBASAN (ALBANIAN PREFECTURE) IN THE ALBANIAN MONARCHY (1928-1939) (2015)

We Monarchy years (1928-1939) Elbasan in accordance with the policies of the Central Government made important steps in the evolution and development in the prefecture. What is notable not only evidenced in Elbasan but also in its sub-prefectures and municipalities during 1928-1939 were efforts, dogged persistence and determination of elbasanasve to separate the east and to embrace the western way of progress, it not only as a concept but the complexity of it (policy reforms). Among the aspects of life to progress on the Monarchy period Elbasan Prefecture mention: progress in the field of education, which consisted in the opening of schools, teacher preparation staff, drafting of texts and the fight against illiteracy; the humanity expressed in the support and contribution in cash that the population of this area given to national education; development of infrastructure (roads, bridges); The first steps of progress in the industry (factories before the domestic capital); in the cultural field (creation of the Cultural Society Kristoforidhi, opening the Library Qemal Baholli etc.); social emancipation (branch of the Society Albanian woman in Elbasan, reform on the woman's face detection) and in an active political life.
Zur Synthese von Peptiden mit Eigenschaften des Human‐Proinsulin‐C‐Peptids (<sub>h</sub>C‐Peptid), III. Darstellung der Sequenzen 14–17 und 9–13 des Human‐Proinsulin‐C‐Peptids (1973)

Abstract Die Synthese von Z‐Gly‐Gly‐Pro‐Gly‐OH ( Nα ‐Benzyloxycarbonyl‐Human‐Proinsulin‐C‐Peptid‐(14–17)‐tetrapeptid), von Z‐Glu(Obu) t ‐Val‐Gln‐Leu‐Gly‐OH ( Nα ‐Benzyloxycarbonyl‐ C γ 9 ‐ tert ‐butoxy‐[Glu 9 , Gln 11 ]Human‐Proinsulin‐C‐Peptid‐)9–13)‐pentapeptid) und von Nps‐Gln(Mbh)‐Val‐Glu(Obu t )‐Leu‐Gly‐OH ( Nα ‐2‐Nitrophenylsulfenyl‐ C γ 9 ‐4,4′‐dimethoxybenz‐hydryl‐ C γ 11 ‐ tert ‐butoxy‐Human‐Proinsulin‐C‐Peptid‐(9–13)‐pentapeptid) wird beschrieben.
Minimum Power Multicast Beamforming With Superposition Coding for Multiresolution Broadcast and Application to NOMA Systems (2015)

Multicast beamforming with superposition coding (SC) is studied for multiresolution broadcast where both data streams of high priority (HP) and low priority (LP) are to be transmitted for a user close to a base station (BS), while only data stream of LP is to be transmitted to a user not close to the BS (e.g., a cell-edge user). Using SC, a minimum total transmission power beamforming problem has been formulated to find beamforming vectors and powers for both users. For given normalized beamforming vectors, a closed-form expression for the optimal power allocation is derived from which an iterative algorithm is considered to find beamforming vectors. The proposed multicast beamforming with SC is applied to nonorthogonal multiple access (NOMA) systems to support multiple users as a two-stage beamforming method.
Some effects of other viruses and of temperature on the multiplication of potato virus X (1964)

SUMMARY The severity of symptoms shown by tobacco plants infected with potato virus X (PVX) was correlated with virus concentration. The virus multiplied optimally between 20 and 24deg;C. and increasing temperature above 25°C. decreased symptoms and virus concentration. PVX did not multiply detectably in plants at 34°C. Tobacco leaves systemically infected with both PVX and potato virus Y (PVY) contained more PVX than leaves infected with PVX alone. The greatest relative increase was at 31°C. because at this temperature PVX alone barely multiplied and failed to move out of the inoculated leaf. The concentration of PW was not altered by the presence of PVX and the optimum temperature for its multiplication appeared to be 28°C. Three other viruses (namely tobacco mosaic virus, cucumber mosaic virus (yellow strain), and henbane mosaic virus) that multiply at 31°C. also assisted the systemic spread of PVX at this temperature, possibly by aiding its movement between mesophyll cells and into the phloem. PVY may also aid PVX at lower temperatures mainly by increasing the number of cells it infects.
The Symmetry of Emotional and Deliberate Facial Actions (1981)

ABSTRACT Asymmetries of the smiling facial movement were more frequent in deliberate imitations than spontaneous emotional expressions. When asymmetries did occur they were usually stronger on the left side of the face if the smile was deliberate. Asymmetrical emotional expressions, however, were about equally divided between those stronger on the left side of the face and those stronger on the right. Similar findings were obtained for the actions involved in negative emotions, but a small data base made these results tentative.
Synthesis of Deuterium-Labeled Azo Dyes of the Sudan Family (2008)

Carcinogenic amines are formed in vivo during the metabolism of Sudan azo dyes. The identification and assay of these polluting agents requires the availability of deuterated analogues. Accordingly, two series of derivatives labeled on the phenylazo and naphthol moieties were synthesized. The new compounds were obtained in satisfactory chemical yields and with an excellent degree of labeling. The structures were confirmed by 1H NMR spectroscopy and high-resolution mass spectrometry.
High-resolution air-clad imaging fibers (2018)

We present a coherent fiber bundle comprising over 11,000 doped silica cores separated by an air-filled cladding. The fiber is characterized, and its imaging quality is shown to be a substantial improvement over the commercial state of the art, with comparable resolution over an unparalleled spectral range.
Glucagon and cAMP inhibit cholesterol 7α‐hydroxylase (CYP7a1) gene expression in human hepatocytes (2005)

The gene encoding cholesterol 7alpha-hydroxylase (CYP7A1) is tightly regulated to control bile acid synthesis and maintain lipid homeostasis. Recent studies in mice suggest that bile acid synthesis is regulated by the fasted-to-fed cycle, and fasting induces CYP7A1 gene expression in parallel to the induction of peroxisome proliferators-activated receptor gamma co-activator 1alpha (PGC-1alpha) and phosphoenolpyruvate carboxykinase (PEPCK). How glucagon regulates CYP7A1 gene expression in the human liver is not clear. Here we show that glucagon and cyclic adenosine monophosphate (cAMP) strongly repressed CYP7A1 mRNA expression in human primary hepatocytes. Reporter assays confirmed that cAMP and protein kinase A (PKA) inhibited human CYP7A1 gene transcription, in contrast to their stimulation of the PEPCK gene. Mutagenesis analysis identified a PKA-responsive region located within the previously identified HNF4alpha binding site in the human CYP7A1 promoter. Glucagon and cAMP increased HNF4alpha phosphorylation and reduced the amount of HNF4alpha present in CYP7A1 chromatin. Our findings suggest that glucagon inhibited CYP7A1 gene expression via PKA phosphorylation of HNF4alpha, which lost its ability to bind the CYP7A1 gene and resulted in inhibition of human CYP7A1 gene transcription. In conclusion, this study unveils a species difference in nutrient regulation of the human and mouse CYP7A1 gene and suggests a discordant regulation of bile acid synthesis and gluconeogenesis by glucagon in human livers during fasting.
Ultra-compact, high efficiency, quartz-enhanced photoacoustic spectroscopy based trace gas sensor platform (2006)

An ultra-compact trace gas sensor platform based on photoacoustic spectroscopy using a quartz tuning fork (QTF) and components-off-the-shelf has been developed for sensor networks. Sensitivity limited by the intrinsic QTF thermal noise has been demonstrated
Clonal Evolution Including Partial Loss of Human Leukocyte Antigen Genes Favoring Extramedullary Acute Myeloid Leukemia Relapse After Matched Related Allogeneic Hematopoietic Stem Cell Transplantation (2012)

These results suggest that the loss of HLA class I haplotype also occurs in AML relapse after HLA-matched related HSCT. Partial loss of several HLA class I genes and subsequent reduced presentation of minor histocompatibility antigens and reduced ligation of activating natural killer-cell receptors may explain the loss of graft-versus-leukemia response and extramedullary AML relapse in tissue with reduced immunologic surveillance.
Zero-valent iron treatment of RDX-containing and perchlorate-containing wastewaters from an ammunition-manufacturing plant at elevated temperatures (2006)

The use of zero-valent iron for treating wastewaters containing RDX and perchlorate from an army ammunition plant (AAP) in the USA at elevated temperatures and moderately elevated temperature with chemical addition was evaluated through batch and column experiments. RDX in the wastewater was completely removed in an iron column after 6.4 minutes. Increasing the temperature to 75 degrees C decreased the required retention time to 2.1 minutes for complete RDX removal. Perchlorate in the wastewater was completely removed by iron at an elevated temperature of 150 degrees C in batch reactors in 6 hours without pH control. Significant reduction of perchlorate by zero-valent iron was also achieved at a more moderate temperature (75 degrees C) through use of a 0.2 M acetate buffer. Based on the evaluation results, we propose two innovative processes for treating RDX-containing and perchlorate-containing wastewaters: a temperature and pressure-controlled batch iron reactor and subsequent oxidation by existing industrial wastewater treatment plant; and reduction by consecutive iron columns with heating and acid addition capabilities and subsequent oxidation.
Mechanism of action of chounghwamycin A. (1989)

The mechanism of action of chounghwamycin A to tumor cells resembles that of actinomycin D, preferentially inhibiting the synthesis of RNA. The interaction of chounghwamycin A with DNA was studied, and the results indicated that chounghwamycin A could not cause any scission in tested DNA. However, an induced mobility shift of the DNA in agarose gel electrophoresis was observed. When the concentration of chounghwamycin A gradually increased, the migration rate of closed circular form DNA is gradually slowed. At a critical concentration of chounghwamycin A, 15.6 micrograms/ml, the migration rate of closed circular form DNA reaches its minimum value. As more choungwamycin A is added, the mobility of the closed circular DNA increases gradually again, suggesting that the intercalation of chounghwamycin A in DNA is the primary mechanism of its action against tumor cells.
HOMA-Estimated Insulin Resistance Is an Independent Predictor of Cardiovascular Disease in Type 2 Diabetic Subjects (2002)

HOMA-IR is an independent predictor of CVD in type 2 diabetes. The improvement of insulin resistance might have beneficial effects not only on glucose control but also on CVD in patients with type 2 diabetes.
The effects of dopants on the electrical resistivity in lead magnesium niobate multilayer ceramic capacitors (1989)

Electrical resistivity studies were performed on multilayer ceramic capacitors (MLC) based on lead magnesium niobate and containing dopants of lead titanate, lead zinc niobate, and lead cobalt niobate. The results showed that lead titanate and/or lead zinc niobate had no effect on the electrical resistivity while lead cobalt niobate decreased the resistivity. In samples without lead cobalt niobate, the authors observed a conduction mechanism with an activation energy of approximately 1 eV, which is commonly observed in barium titanate based dielectrics. This is attributed to ionic conduction by the motion of oxygen vacancies. The increase in conductivity (or decrease in resistivity) resulting from the addition of lead cobalt niobate was attributed to electronic conduction through charge hopping among the cations. This conduction mechanism was characterized by an activation energy of approximately 0.5 eV. The transition between electronic and ionic conduction was a function of temperature and the concentration of lead cobalt niobate. Since the activation energy associated with the long-term failure was previously determined by a matrix of temperature and voltage accelerated-life tests to be approximately 1 eV, the authors conclude that conduction through charge hopping is not affecting the long-term reliability of these devices.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Synthesis and characterization of transparent conducting oxide cobalt–nickel spinel films (2001)

Cobalt–nickel oxide films of nominal 100 nm thickness, and resistivity on the order of 10−2 Ω cm have been deposited by spin casting from both aqueous and organic precursor solutions followed by annealing at 450 °C in air. Films deposited on sapphire substrates exhibit a refractive index of about 1.7 and are relatively transparent in the wavelength region from 0.6 to 10.0 μm. They are also magnetic. The electrical and spectroscopic properties of the oxides have been studied as a function of the x=Co/(Co+Ni) ratio. An increase in film resistivity was found upon substitution of other cations (Zn2+, Al3+,…) for Ni in the spinel structure. However, some improvement in the mechanical properties of the films resulted. A combination of x-ray diffraction, x-ray photoelectron spectroscopy, UV/Vis, and Raman spectroscopy indicated that NiCo2O4 is the primary conducting component and that the conductivity reaches a maximum at this stoichiometry. When x&lt;0.67, NiO forms leading to an increase in resistivity; when x&gt;0.67, the oxide was all spinel but the increased Co content lowered the conductivity. The influence of cation charge state and site occupancy in the spinel structure markedly affects calculated electron band structures and likely influences an anomalous switch of p-type conductivity to n-type conductivity seen at x=0.67. Electronic structure modeling studies also suggest the important role of the Ni3+ cation in the conductivity mechanism. Finally, Raman spectra of the films were relatively easy to obtain and therefore were useful as a routine tool for identifying composition and optimizing conductivity.
Microneedle-Based Detection of Ketone Bodies along with Glucose and Lactate: Toward Real-Time Continuous Interstitial Fluid Monitoring of Diabetic Ketosis and Ketoacidosis (2019)

Diabetic ketoacidosis (DKA), a severe complication of diabetes mellitus with potentially fatal consequences, is characterized by hyperglycemia and metabolic acidosis due to the accumulation of ketone bodies, which requires people with diabetes to monitor both glucose and ketone bodies. However, despite major advances in diabetes management mainly since the emergence of new-generation continuous glucose monitoring (CGM) devices capable of in vivo monitoring of glucose directly in the interstitial fluid (ISF), the continuous monitoring of ketone bodies is yet to be addressed. Here, we present the first use of a real-time continuous ketone bodies monitoring (CKM) microneedle platform. The system is based on the electrochemical monitoring of β-hydroxybutyrate (HB) as the dominant biomarker of ketone formation. Such real-time HB detection has been realized using the β-hydroxybutyrate dehydrogenase (HBD) enzymatic reaction and by addressing the major challenges associated with the stable confinement of the enzyme/cofactor couple (HBD/NAD<sup>+</sup>) and with a stable and selective low-potential fouling-free anodic detection of NADH. The resulting CKM microneedle device displays an attractive analytical performance, with high sensitivity (with low detection limit, 50 μM), high selectivity in the presence of potential interferences, along with good stability during prolonged operation in artificial ISF. The potential applicability of this microneedle sensor toward minimally invasive monitoring of ketone bodies has been demonstrated in a phantom gel skin-mimicking model. The ability to detect HB along with glucose and lactate on a single microneedle array has been demonstrated. These findings pave the way for CKM and for the simultaneous microneedle-based monitoring of multiple diabetes-related biomarkers toward a tight glycemic control.