gebhart/patrepeval huggingface dataset:
Ultrasonic processing of thermoplastic foam (1990)

Abstract Ultrasonically induced bubble formation for the production of thermoplastic foam was investigated experimentally and theoretically as a basic study. A general purpose polystyrene and blends of low density polyethylene and polyethylene wax were saturated with nitrogen gas under various pressures and the ultrasonic excitation was applied to the polymer system upon release of gas pressure. The ultrasonic nucleation of bubbles in the polymer matrix was modeled by utilizing the classical nucleation theory. The negative pressure generated by the ultrasonic excitation was considered as the environmental pressure at the moment of nucleation. The experimental results showed that the heterogeneous nucleation must be used for ultrasonic foaming of the viscous fluid and the homogeneous nucleation for the low viscosity fluid. The theoretical analysis also indicated that the ultrasonic nucleation can be applied to the production of thermoplastic foam if the ultrasonic excitation generates large enough negative pressure.
<i>N</i><sup>1</sup>,<i>N</i><sup>3</sup>-Di-2-pyridylmalonamide (2007)

The title compound, C13H12N4O2, consists of two pyridine rings connected by a malonamide chain. The dihedral angle between the two pyridine rings is 88.84 (7)°. The crystal packing is stabilized by N—H⋯O hydrogen bonds.
Antibody Response and Protection Induced by Immunization with Smooth and Rough Strains in Experimental Salmonellosis (1968)

The antibody response of mice to a smooth strain of Salmonella typhimurium was shown previously to be extremely rapid and potent. As measured by the complement-mediated bactericidal reaction, it was also found to be highly specific as well as reproducible. Experiments which studied the effects of antigen type (live or heat-killed), antigen dose, and the route of immunization indicated that the most rapid and highest antibody response was achieved with live, smooth organisms injected by the intraperitoneal route. Living vaccines of rough strains of either S. typhimurium or S. enteritidis induced antibodies directed against the corresponding smooth organisms. The response to the rough strains was apparently due to antibody production rather than to the simple release of preformed natural antibody. The duration of protection conferred by the rough strain vaccines was closely correlated with the endotoxic content of the immunizing strain. Smooth heat-killed vaccines and a rough live vaccine protected against homologous but not heterologous challenge. In contrast, immunization with a smooth live vaccine protected mice against both homologous and heterologous challenge infections. Protection was not due to a local effect in the peritoneal cavity, since mice were also protected against subcutaneous challenge. The secondary antibody response, induced in immunized animals by the virulent challenge infection, was demonstrated to be rapid and potent, and hence a factor to be considered in protection.
Pyruvate-extended Amino Acid Derivatives as Highly Potent Inhibitors of Carboxyl-terminal Peptide Amidation (1997)

Carboxyl-terminal amidation, a required post-translational modification for the bioactivation of many neuropeptides, entails sequential enzymatic action by peptidylglycine monooxygenase (PAM, EC 1.14.17.3) and peptidylamidoglycolate lyase (PGL, EC 4.3.2.5). The monooxygenase, PAM, first catalyzes conversion of a glycine-extended pro-peptide to the corresponding alpha-hydroxyglycine derivative, and the lyase, PGL, then catalyzes breakdown of this alpha-hydroxyglycine derivative to the amidated peptide plus glyoxylate. We now introduce the first potent inhibitors for peptidylamidoglycolate lyase. These inhibitors, which can be viewed as pyruvate-extended N-acetyl amino acids, constitute a novel class of compounds. They were designed to resemble likely transient species along the reaction pathway of PGL catalysis. A general synthetic procedure for preparation of pyruvate-extended N-acetyl amino acids or peptides is described. Since these compounds possess the 2,4-dioxo-carboxylate moiety, their solution tautomerization was investigated using both NMR and high performance liquid chromatography analyses. The results establish that freshly prepared solutions of N-Ac-Phe-pyruvate consist predominantly of the enol tautomer, which then slowly tautomerizes to the diketo form when left standing for several days in an aqueous medium; upon acidification, formation of the hydrate tautomer occurs. Kinetic experiments established that these novel compounds are highly potent, pure competitive inhibitors of PGL. Kinetic experiments with the ascorbate-dependent copper monooxygenases, PAM and dopamine-beta-monooxygenase, established that these compounds also bind competitively with respect to ascorbate; however, pyruvate-extended N-acyl-amino acid derivatives possessing hydrophobic side chains are much more potent inhibitors of PGL than of PAM. Selective targeting of N-Ac-Phe-pyruvate so as to inhibit the lyase, but not the monooxygenase, domain was demonstrated with the bifunctional amidating enzyme of Xenopus laevis. The availability of potent inhibitors of PGL should facilitate studies regarding the possible biological role of alpha-hydroxyglycine-extended peptides.
ELECTRONIC MEASUREMENT OF PARTICLE SIZE (1960)

A novel counter which detects and measures particles in suspension by means of their electrical resistance is described. This instrument can count red blood cells at rates exceeding 5000 particles per second, and with modifications is capable of determinlng the volumes of spheres as small as 0.2 mu in diameter. The operation of the counter and its advantages over optical counters are discussed, along with its applications to biology, medicine, and industry. (auth)
Functional and Morphologic Comparison of Two Methods to Produce Transient Retinal Ischemia in the Rat (2001)

The degree of retinal injury after transient retinal ischemia was more severe at 1 day after reperfusion in the HIOP method compared to the SL method but was similar at 7 days in both models. Furthermore, our data suggests that functional assessment of ischemic damage by electroretinography may be a more sensitive parameter than conventional histopathologic quantification. The timing of either measurement relative to the ischemic stimulus is critical because histologic measurements performed too early after ischemia may underestimate the degree of injury.
A Computational Approach to Botanical Drug Design by Modeling Quantitative Composition–activity Relationship (2006)

Herbal medicine has been successfully applied in clinical therapeutics throughout the world. Following the concept of quantitative composition-activity relationship, the presented study proposes a computational strategy to predict bioactivity of herbal medicine and design new botanical drug. As a case, the quantitative relationship between chemical composition and decreasing cholesterol effect of Qi-Xue-Bing-Zhi-Fang, a widely used herbal medicine in China, was investigated. Quantitative composition-activity relationship models generated by multiple linear regression, artificial neural networks, and support vector regression exhibited different capabilities of predictive accuracy. Moreover, the proportion of two active components of Qi-Xue-Bing-Zhi-Fang was optimized based on the quantitative composition-activity relationship model to obtain new formulation. Validation experiments showed that the optimized herbal medicine has greater activity. The results indicate that the presented method is an efficient approach to botanical drug design.
Surgical Treatment of Recalcitrant Plantar Fasciitis (1996)

Twenty-six patients (35 feet) underwent partial plantar fasciectomy with neurolysis of the nerve to the abductor digiti quinti muscle. Nonsurgical treatment for plantar fasciitis had been unsuccessful in these patients. Patients were followed after surgery for an average of 37.5 months. Six patients were male and 20 patients were female; the average age was 49 years. All patients had failed to respond to nonsurgical treatment for an average of 21.5 months. In addition to routine history and physical examination patients were evaluated before and after surgery with a subjective foot rating system, and a detailed questionnaire was used to assess post-operative functional outcome. Thirty-two patients (92%) had a satisfactory functional outcome, and three patients (8%) had an unsatisfactory result (21 excellent, 11 good, 3 fair, 0 poor). The Maryland Foot Score increased from a preoperative average of 74.8/100 points to a postoperative average of 90.6/100 points. Four patients (11%) had postoperative complications, including superficial wound infection (two patients), deep venous thrombosis (one patient), and superficial phlebitis (one patient), all of which resolved uneventfully with treatment. Ten patients (28.6%) reported some degree of heel pain after surgery. All 10 patients denied limitation in activity related to postoperative pain. The average period before return to daily activity and restricted work duty was 5.6 weeks and to full work duty without restriction was 8.7 weeks. Although the length of time for partial or complete resolution of symptoms is variable, a successful treatment outcome can be expected in most patients who are treated for recalcitrant plantar fasciitis.
Engineering Surface Energy and Nanostructure of Microporous Films for Expanded Membrane Distillation Applications (2016)

We investigated the factors that determine surface omniphobicity of microporous membranes and evaluated the potential application of these membranes in desalination of low surface tension wastewaters by membrane distillation (MD). Specifically, the effects of surface morphology and surface energy on membrane surface omniphobicity were systematically investigated by evaluating wetting resistance to low surface tension liquids. Single and multilevel re-entrant structures were achieved by using cylindrical glass fibers as a membrane substrate and grafting silica nanoparticles (SiNPs) on the fibers. Surface energy of the membrane was tuned by functionalizing the fiber substrate with fluoroalkylsilane (FAS) having two different lengths of fluoroalkyl chains. Results show that surface omniphobicity of the modified fibrous membrane increased with higher level of re-entrant structure and with lower surface energy. The secondary re-entrant structure achieved by SiNP coating on the cylindrical fibers was found to play a critical role in enhancing the surface omniphobicity. Membranes coated with SiNPs and chemically modified by the FAS with a longer fluoroalkyl chain (or lower surface energy) exhibited excellent surface omniphobicity and showed wetting resistance to low surface tension liquids such as ethanol (22.1 mN m(-1)). We further evaluated performance of the membranes in desalination of saline feed solutions with varying surface tensions by membrane distillation (MD). The engineered membranes exhibited stable MD performance with low surface tension feed waters, demonstrating the potential application omniphobic membranes in desalinating complex, high salinity industrial wastewaters.
SQL Ledger: Cryptographically Verifiable Data in Azure SQL Database (2021)

SQL Ledger is a new technology that allows cryptographically verifying the integrity of relational data stored in Azure SQL Database and SQL Server. This is achieved by maintaining all historical data in the database and persisting its cryptographic (SHA-256) digests in an immutable, tamper-evident ledger. Digests representing the overall state of the ledger can then be extracted and stored outside of the RDBMS to protect the data from any attacker or high privileged user, including DBAs, system and cloud administrators. The ledger and the historical data are managed transparently, offering protection without any application changes. Historical data is maintained in a relational form to support SQL queries for auditing, forensics and other purposes. SQL Ledger provides cryptographic data integrity guarantees while maintaining the power, flexibility and performance of a commercial RDBMS. In contrast to Blockchain solutions that aim for full integrity, SQL Ledger offers a form of integrity protection known as Forward Integrity. The proposed technology is significantly cheaper and more secure than traditional solutions that establish trust based on audits or mediators, but also has substantial advantages over Blockchain solutions that are complex to deploy, lack data management capabilities and suffer in terms of performance due to their decentralized nature.
Disrupted Blood-Retina Lysophosphatidylcholine Transport Impairs Photoreceptor Health But Not Visual Signal Transduction (2019)

Retinal photoreceptor cells contain the highest concentration of docosahexaenoic acid (DHA) in our bodies, and it has been long assumed that this is critical for supporting normal vision. Indeed, early studies using DHA dietary restriction documented reduced light sensitivity by DHA-deprived retinas. Recently, it has been demonstrated that a major route of DHA entry in the retina is the delivery across the blood–retina barrier by the sodium-dependent lipid transporter, Mfsd2a. This discovery opened a unique opportunity to analyze photoreceptor health and function in DHA-deprived retinas using the Mfsd2a knock-out mouse as animal model. Our lipidome analyses of Mfsd2a −/− retinas and outer segment membranes corroborated the previously reported decrease in the fraction of DHA-containing phospholipids and a compensatory increase in phospholipids containing arachidonic acid. We also revealed an increase in the retinal content of monounsaturated fatty acids and a reduction in very long chain fatty acids. These changes could be explained by a combination of reduced DHA supply to the retina and a concomitant upregulation of several fatty acid desaturases controlled by sterol regulatory element-binding transcription factors, which are upregulated in Mfsd2a −/− retinas. Mfsd2a −/− retinas undergo slow progressive degeneration, with ∼30% of photoreceptor cells lost by the age of 6 months. Despite this pathology, the ultrastructure Mfsd2a −/− photoreceptors and their ability to produce light responses were essentially normal. These data demonstrate that, whereas maintaining the lysophosphatidylcholine route of DHA supply to the retina is essential for long-term photoreceptor survival, it is not important for supporting normal phototransduction. SIGNIFICANCE STATEMENT Phospholipids containing docosahexaenoic acid (DHA) are greatly enriched in the nervous system, with the highest concentration found in the light-sensitive membranes of photoreceptor cells. In this study, we analyzed the consequences of impaired DHA transport across the blood–retina barrier. We have found that, in addition to a predictable reduction in the DHA level, the affected retinas undergo a complex, transcriptionally-driven rebuilding of their membrane lipidome in a pattern preserving the overall saturation/desaturation balance of retinal phospholipids. Remarkably, these changes do not affect the ability of photoreceptors to produce responses to light but are detrimental for the long-term survival of these cells.
Sol-gel-derived lead and calcium lead titanate pyroelectric detectors on silicon MEMS structures (1996)

Pyroelectric detectors based on PbTiO<SUB>3</SUB> (PTO) and Pb<SUB>1-x</SUB>Ca<SUB>x</SUB>TiO<SUB>3</SUB> (PCT<SUB>x</SUB>) were fabricated and evaluated on thin silicon micro electrical-mechanical structures (MEMS) utilizing a new sol-gel technique. The sol-gel approach allows arbitrary Pb:Ca ratio, and is fully compatible with existing CMOS processes. The novel precursor chemistry developed in our laboratory is not moisture sensitive, and has a shelf-life of many months. Layers of PTO precursor were spin-coated onto 4 micrometers thick silicon membrane structures. Heat treatment at 700 degree(s)C yielded crack-free films approximately 0.3 micrometers thick. Contacts to the top of the pyroelectric film and to the silicon membrane were made by thermal evaporation of aluminum. The reduced thermal capacitance and improved thermal isolation offered by the MEMS membrane structure have significantly improved the performance of our device over typical bulk single crystal or ceramic devices. Pyroelectric responsivity of 2.5 volt/watt was measured at (lambda) equals 10.6 micrometers for a first generation simple membrane structure without poling or electrical bias. SPICE analysis of a distributed thermal circuit model indicates the potential for two orders of magnitude improvement in device sensitivity for optimized membrane structures currently under construction. These results also indicate that a fully integrated high-performance room temperature imaging array for use in the far IR can be realized at low cost.
Natural Variation in Preparation for Nutrient Depletion Reveals a Cost–Benefit Tradeoff (2015)

Maximizing growth and survival in the face of a complex, time-varying environment is a common problem for single-celled organisms in the wild. When offered two different sugars as carbon sources, microorganisms first consume the preferred sugar, then undergo a transient growth delay, the "diauxic lag," while inducing genes to metabolize the less preferred sugar. This delay is commonly assumed to be an inevitable consequence of selection to maximize use of the preferred sugar. Contrary to this view, we found that many natural isolates of Saccharomyces cerevisiae display short or nonexistent diauxic lags when grown in mixtures of glucose (preferred) and galactose. These strains induce galactose utilization (GAL) genes hours before glucose exhaustion, thereby "preparing" for the transition from glucose to galactose metabolism. The extent of preparation varies across strains, and seems to be determined by the steady-state response of GAL genes to mixtures of glucose and galactose rather than by induction kinetics. Although early GAL gene induction gives strains a competitive advantage once glucose runs out, it comes at a cost while glucose is still present. Costs and benefits correlate with the degree of preparation: strains with higher expression of GAL genes prior to glucose exhaustion experience a larger upfront growth cost but also a shorter diauxic lag. Our results show that classical diauxic growth is only one extreme on a continuum of growth strategies constrained by a cost-benefit tradeoff. This type of continuum is likely to be common in nature, as similar tradeoffs can arise whenever cells evolve to use mixtures of nutrients.
Single Quartz Crystal Point Focusing X-Ray Monochromator (1955)

A point focusing x-ray monochromator which uses Bragg reflection from a single lamina of quartz bent in such a way that its atomic planes are given two principal radii of curvature has been constructed for use in low-angle diffraction studies. It was found that the crystal reflects 2.78% of the incident Cu Kα1 radiation into a converging beam one meter long, with a resolution of better than half a millimeter except for a very faint halo. The instrument has been used to obtain diffraction patterns from normal and sickle-cell human hemoglobin and also from southern bean mosaic virus. The speed of the present instrument is roughly two hundred times that of an equivalent pinhole collimating system. A similar but still faster instrument is being constructed.
Modeling of supercritical fluid extraction from herbaceous matrices (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTModeling of supercritical fluid extraction from herbaceous matricesErnesto Reverchon, Giorgio Donsi, and Libero Sesti OsseoCite this: Ind. Eng. Chem. Res. 1993, 32, 11, 2721–2726Publication Date (Print):November 1, 1993Publication History Published online1 May 2002Published inissue 1 November 1993https://pubs.acs.org/doi/10.1021/ie00023a039https://doi.org/10.1021/ie00023a039research-articleACS PublicationsRequest reuse permissionsArticle Views1101Altmetric-Citations165LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Isolation and Structure Determination of New Antibacterial Peptide Curacomycin Based on Genome Mining (2017)

Abstract A new antibacterial cyclic peptide, named curacomycin ( 1 ), and its analogue dechlorocuracomycin ( 2 ) were isolated from Streptomyces curacoi (NBRC 12761 T ) and Streptomyces noursei (NBRC 15452 T ), respectively, by using genome mining. The chemical structures of these two peptides were determined by using a combination of MS (ESI) and NMR spectroscopy. The structure of compound 1 was determined to be a cyclic peptide that consisted of six amino acids, including: valine (Val), leucine (Leu), isoleucine (Ile), ornithine (Orn), β‐hydroxyasparagine (OHAsn), and 5‐chlorotryptophan (ClTrp). The NMR data of compound 2 were very similar to that of compound 1 , which indicated that the structure of compound 2 was a dechlorinated analogue of compound 1 . A comparison of the antimicrobial activities of these two peptides indicated that the presence of chlorine in compound 1 was critical for its antimicrobial activity. The proposed biosynthetic gene clusters for compounds 1 and 2 were found in the genome data of S. curacoi and S. noursei , respectively. The functions of the biosynthetic genes were considered by comparison of the two gene clusters.
Sensor fusion and complex data analysis for predictive maintenance (2003)

An essential step toward the development of an intelligent substation is to provide self-diagnosing capability at the equipment level. Transformers, circuit breakers and other substation equipment should be enabled to detect their potential failures and make life expectancy prediction without human interference. This paper focuses on the development of an on-line equipment diagnostics using artificial intelligence and a nonlinear observer to prevent catastrophic failures in substation equipment, thus providing preventive maintenance. Key elements of the system are a nonlinear observer, system identifier, and fault detector that use a uniquely designed neuro-fuzzy inference engine. Experimental results from application of this system to a distribution transformer are presented.