gebhart/patrepeval huggingface dataset:
Hunting for Plant Nitric Oxide Synthase Provides New Evidence of a Central Role for Plastids in Nitric Oxide Metabolism (2009)

Nitric oxide (NO) has emerged as a central signaling molecule in plants and animals. However, the long search for a plant NO synthase (NOS) enzyme has only encountered false leads. The first works describing a pathogen-induced NOS-like plant protein were soon retracted. New hope came from the identification of NOS1, an Arabidopsis thaliana protein with an atypical NOS activity that was found to be targeted to mitochondria in roots. Although concerns about the NO-producing activity of this protein were raised (causing the renaming of the protein to NO-associated 1), compelling data on its biological role were missing until recently. Strong evidence is now available that this protein functions as a GTPase that is actually targeted to plastids, where it might be required for ribosome function. These and other results support the argument that the defective NO production in loss-of-function mutants is an indirect effect of interfering with normal plastid functions and that plastids play an important role in regulating NO levels in plant cells.
Normal human peripheral blood mononuclear cells mobilized with granulocyte colony-stimulating factor have increased osteoclastogenic potential compared to nonmobilized blood (1996)

Single-cell suspensions of granulocyte colony-stimulating factor (G-CSF)-mobilized peripheral blood mononuclear cells (G-PBMC) cultured in alpha minimal essential medium (alphaMEM) containing 10% fetal bovine serum formed multicellular aggregates within 24 hours. In six separate experiments, formation of aggregates appeared to be dependent on cell density per surface area, so that 5.8 +/- 1.3 aggregates formed per 1 x 10(5) cells when G-PBMC were cultured at densities greater than or equal to 1 x 10(5) cells/cm2. The frequency of aggregate formation was less than 1 per 10(5) cells when G-PBMC were cultured at densities less than 1 x 10(5) cells/cm2. Once formed, aggregates became adherent within 72 hours, and then, over the course of 21 days, released CD3/CD4/CD25-positive cells into the supernatant. This T-cell production peaked between days 7 and 14, reaching a total of 1,269 +/- 125.9 cells released per aggregate by day 21. Between days 14 and 21, the aggregates also generated macroscopic clusters of adherent mononuclear and giant multinucleated cells that stained positive for tartrate-resistant acid phosphatase (TRAP). At 4 weeks, the macroscopic foci coalesced into monolayers. Multinucleated TRAP-positive cells were distinguished from macrophage polykaryons by the absence of CD14 expression and the presence of osteoclast-specific membrane receptors for calcitonin and alphavbeta3-vitronectin. The osteoclast nature of these cells was further demonstrated by their ability to form resorption lacunae on dentine slices. Comparable osteoclast formation was not detected in cultures of normal marrow or normal nonmobilized peripheral blood.
Design Issues of Shingled Write Disk for Database (2014)

To maintain the continuing growth of bit density in magnetic recording media, the disk industry will have to change technologies. Shingled write disks are expected to be the next generation of high capacity magnetic disks and alreadyin prototype. Shingled write technology is not disruptive at the level of disk design and manufacturing, but as shingled writes prevent updates in place, the technology is disruptive at the level of usage. It is possible to design a disk device driver or disk firmware that allows a shingled write disk to be used as a drop in replacement for traditional disks. Database implementations however have traditionally bypassed the file system and accessed the disk directly in order to achieve better performance. We discuss here adaptation of B+-trees and linear hash tables to shingled write disk to support indexed database tables and secondary indices. Our proposal is based on dividing the disk in low-capacity Random Access Zones (RAZ) and high capacity Log Access Zones (LAZ). The LAZ use the shingled disk effectively while RAZ places guard bands around each track in the zone in order to regain the capacity of in-place updates at the costs of loosing capacity.
Growth factor levels in leukocyte‐poor platelet‐rich plasma and correlations with donor age, gender, and platelets in the Japanese population (2019)

This clinical study shows a significant variation of PRP among individual patients and that this variation is influenced by the age and the platelet counts of the subjects. Our data demonstrate that patient characteristics account for the differences in PRP physiological activity.
High bandwidth and responsivity mid-infrared graphene photodetector based on a modified metal–dielectric–graphene architecture (2019)

In this paper, a novel graphene-based mid-infrared photoconductive photodetector is designed that is composed of nanophotodetectors in series and parallel forming an array. The whole structure utilizes a single "unpatterned" graphene layer in a modified metal-dielectric-graphene (MDG) architecture that is composed of a conventional MDG structure combined with additional nanoelectrodes for photocurrent guiding and absorption enhancement. Finite difference time domain and finite element methods are utilized to obtain optical and electrostatic characteristics of the photodetector. Specifically, responsivity, quantum efficiency, dark current, bandwidth, noise equivalent power (NEP), and specific detectivity (<i>D</i><sup>*</sup>) are extracted by employing realistic graphene as well as graphene-metal characteristics. For an optimized device, maximum absorption efficiency is as much as 70% at a wavelength of <i>λ</i>=6.77 <i>μm</i>; however, the peak absorption wavelength can be effectively tuned between <i>λ</i>=6<i>-</i>7 <i>μm</i>. It is shown that increasing the drain-source voltage enhances the responsivity and bandwidth with a side effect of increasing the dark current. Responsivity of the 2×2 photodetector is <i>R</i><sub>A</sub>=0.63 <i>AW</i><sup>-1</sup> for <i>V</i> <sub><i>DS</i></sub> =0.5 <i>V</i> with <i>I</i> <sub><i>Dark</i></sub> =350 <i>μA</i>, <i>NEP</i>=16.91 <i>pW</i>/√<i>Hz</i>, and <i>D</i><sup>*</sup>=1.53×10<sup>5</sup> Jones.
A TCP Tuning Daemon (2002)

Many high performance distributed applications require high network throughput but are able to achieve only a small fraction of the available bandwidth. A common cause of this problem is improperly tuned network settings. Tuning techniques, such as setting the correct TCP buffers and using parallel streams, are well known in the networking community, but outside the networking community they are infrequently applied. In this paper, we describe a tuning daemon that uses TCP instrumentation data from the Unix kernel to transparently tune TCP parameters for specified individual flows over designated paths. No modifications are required to the application, and the user does not need to understand network or TCP characteristics.
Search frictions, housing prices and growth (2019)

Rising house prices have a positive impact on real gross domestic product (GDP) through the consumption effect and the construction of new houses (housing investment). Basically, the strength of this positive effect relies on a large share of homeowners (especially regarding the consumption effect). At the same time, however, a greater share of homeowners could encourage unemployment (the so-called Oswald hypothesis), thus damaging economic growth. This theoretical article includes the link among housing tenure, job-search, and labor market outcomes in the relation between housing prices and growth. The main finding of this work is that homeownership may either reinforce or resize the effect of housing prices on economic growth. Empirical support is also provided for this theoretical finding.
Data Resources in the Department of Veterans Affairs (2004)

Both local and national VA databases are valuable resources for investigators who have interests in a wide array of research topics, including diabetes. The potential for investigating important scientific questions with VA databases becomes greater as communications and database management technologies improve.
RPE65 Is Essential for the Function of Cone Photoreceptors in NRL-Deficient Mice (2007)

The data show that RPE65, previously shown to be essential for rod function, is also indispensable for the production of 11-cis retinal for cones and thus for cone function.
Functional Coevolutionary Networks of the Hsp70–Hop–Hsp90 System Revealed through Computational Analyses (2007)

Currently, the identification of groups of amino acid residues that are important in the function, structure, or interaction of a protein can be both costly and prohibitively complex, involving vast numbers of mutagenesis experiments. Here, we present the application of a novel computational method, which identifies the presence of coevolution in a data set, thereby enabling the a priori identification of amino acid residues that play an important role in protein function. We have applied this method to the heat shock protein (Hsp) protein-folding system, studying the network between Hsp70, Hsp90, and Hop (heat shock-organizing protein). Our analysis has identified functional residues within the tetratricopeptide repeat (TPR) 1 and 2A domains in Hop, previously shown to be interacting with Hsp70 and Hsp90, respectively. Further, we have identified significant residues elsewhere in Hop within domains that have been recently proposed as being important for Hop interaction with Hsp70 and/or Hsp90. In addition, several amino acid sites present in groups of coevolution were identified as 3-dimensionally or linearly proximal to functionally important sites or domains. Based on our results, we also investigate a further functional domain within Hop, between TPR1 and TPR2A, which we suggest as being functionally important in the interaction of Hop with both Hsp70 and Hsp90 whether directly or otherwise. Our method has identified all the previously characterized functionally important regions in this system, thereby indicating the power of this method in the a priori identification of important regions for site-directed mutagenesis studies.
Highly Efficient, All-Dielectric, Transmissive Gradient Metasurfaces from the Ultraviolet to the Infrared (2016)

We design and simulate metasurfaces capable of inducing anomalous refraction with efficiency as high as 90%. Metasurfaces are designed for incident wavelengths spanning λ=378nm to λ=1340nm; a composite stacked metasurface capable of spectrum splitting is demonstrated.
Kinetics of Papain-Catalyzed Hydrolysis of α-N-Benzoyl-L-arginine Ethyl Ester and α-N-Benzoyl-L-argininamide<sup>1</sup> (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKinetics of Papain-Catalyzed Hydrolysis of α-N-Benzoyl-L-arginine Ethyl Ester and α-N-Benzoyl-L-argininamide1John R. Whitaker and Myron L. BenderCite this: J. Am. Chem. Soc. 1965, 87, 12, 2728–2737Publication Date (Print):June 1, 1965Publication History Published online1 May 2002Published inissue 1 June 1965https://pubs.acs.org/doi/10.1021/ja01090a034https://doi.org/10.1021/ja01090a034research-articleACS PublicationsRequest reuse permissionsArticle Views522Altmetric-Citations146LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Differential Expression of IFN Regulatory Factor 4 Gene in Human Monocyte-Derived Dendritic Cells and Macrophages (2005)

In vitro human monocyte differentiation to macrophages or dendritic cells (DCs) is driven by GM-CSF or GM-CSF and IL-4, respectively. IFN regulatory factors (IRFs), especially IRF1 and IRF8, are known to play essential roles in the development and functions of macrophages and DCs. In the present study, we performed cDNA microarray and Northern blot analyses to characterize changes in gene expression of selected genes during cytokine-stimulated differentiation of human monocytes to macrophages or DCs. The results show that the expression of IRF4 mRNA, but not of other IRFs, was specifically up-regulated during DC differentiation. No differences in IRF4 promoter histone acetylation could be found between macrophages and DCs, suggesting that the gene locus was accessible for transcription in both cell types. Computer analysis of the human IRF4 promoter revealed several putative STAT and NF-kappaB binding sites, as well as an IRF/Ets binding site. These sites were found to be functional in transcription factor-binding and chromatin immunoprecipitation experiments. Interestingly, Stat4 and NF-kappaB p50 and p65 mRNAs were expressed at higher levels in DCs as compared with macrophages, and enhanced binding of these factors to their respective IRF4 promoter elements was found in DCs. IRF4, together with PU.1, was also found to bind to the IRF/Ets response element in the IRF4 promoter, suggesting that IRF4 protein provides a positive feedback signal for its own gene expression in DCs. Our results suggest that IRF4 is likely to play an important role in myeloid DC differentiation and gene regulatory functions.
Multipartite table methods (2005)

A unified view of most previous table-lookup-and-addition methods (bipartite tables, SBTM, STAM, and multipartite methods) is presented. This unified view allows a more accurate computation of the error entailed by these methods, which enables a wider design space exploration, leading to tables smaller than the best previously published ones by up to 50 percent. The synthesis of these multipartite architectures on Virtex FPGAs is also discussed. Compared to other methods involving multipliers, the multipartite approach offers the best speed/area tradeoff for precisions up to 16 bits. A reference implementation is available at http://www.ens-lyon.fr/LIP/Arenaire/.
Synchrotron and Neutron Tomography of Paleontological Objects on the Facilities of the Kurchatov Institute (2018)

The most important results of tomographic studies of paleontological objects on the facilities of the National Research Centre “Kurchatov Institute” are described. It is shown that the use of the synchrotron and neutron tomography makes it possible to obtain new information on the structure of fossil animals, which is of fundamental importance for taxonomy and morphological analysis of extinct fauna.
Investigation of postoxidation thermal treatments of Si/SiO2 interface in relationship to the kinetics of amorphous Si suboxide decomposition (1998)

Interfacial Si suboxides (SiOx, x&lt;2) are detrimental to transistor performance and are typically minimized during postoxidation anneals. To study the kinetics of SiOx decomposition, thick films (∼2000 Å) of amorphous Si:O:H alloys (0.7&lt;x&lt;1.4) were deposited by remote plasma enhanced chemical vapor deposition and subjected to rapid thermal anneals. Films were characterized by Fourier transform infrared spectroscopy, Raman spectroscopy, ellipsometry, photoluminescence (PL), and transmission electron microscopy. At temperatures &gt;500 °C initially there is a rapid segregation into amorphous Si (a-Si) surrounded by a SiO2 shell which acts as a diffusion barrier decelerating the reaction. Phenomenological modeling of kinetics with a one-dimensional Avrami–Erofe’ve treatment gives an upper limit for a-Si lateral growth rates of 1.2 Å/s at 900 °C with an activation energy of 120 kJ/mol. PL, Raman, transmission electron microscopy and ellipsometry confirm this segregation model in the amorphous state. Due to the rapid initial decomposition and relatively large diffusion coefficients, a simple kinetic hindrance explanation for the 4–8 Å of SiOx at the SiO2/Si interface is unlikely.
Polymer Microspheres with Permanent Antibacterial Surface from Surface-Initiated Atom Transfer Radical Polymerization (2005)

10.1021/ie050225o
The effect of rimantadine on the structure of model and biological membranes. (1989)

The action of the antiviral drug rimantadine on the structure of bilayer lipid membranes (BLM) and RBC membranes was investigated. Structural changes in BLM were recorded by ionophore conductivity changes and by changes in the third harmonic of capacity current signal due to lateral compression of BLM in an electric field. It was shown that the adsorption of rimantadine on BLM results in an increase in ionophore mobility in bilayer membranes of dioleolyllecithin (DOL) and common lipids of bovine brain (CL) and in a decrease in those of azolectin (A). Relative changes in the third harmonic signal also depend on the membrane composition and have different signs. The results may be explained by the rimantadine action on the lipid bilayer structure: "rigidification" of A-membranes and "fluidization" of BLM from DOL and CL. Structural reorganization of RBC membranes as investigated by the ability of the cells to enter a micropipette (inner diameter greater than or equal to 3 microns) thereby undergoing deformation. It was shown that rimantadine influences RBC deformability due to drug induced inhomogenous mechanical membrane properties. Also, rimantadine accelerated the process of artificially induced aggregation of erythrocytes. The relation of the effects on artificial and biological membranes, and the structural changes in the lipid phase of membrane are discussed.
Modeling of Tunneling Current and Gate Dielectric Reliability for Nonvolatile Memory Devices (2004)

We present a hierarchy of tunneling models suitable for the two- and three-dimensional simulation of logic and nonvolatile semiconductor memory devices. The crucial modeling topics are comprehensively discussed, namely, the modeling of the energy distribution function in the channel to account for hot-carrier tunneling, the calculation of the transmission coefficient of single and layered dielectrics, the influence of quasi-bound states in the inversion layer, the modeling of static and transient defect-assisted tunneling, and the modeling of dielectric degradation and breakdown. We propose a set of models to link the gate leakage to the creation of traps in the dielectric layer, the threshold voltage shift, and eventual dielectric breakdown. The simulation results are compared to commonly used compact models and measurements of logic and nonvolatile memory devices.
Risk Management Strategies (1992)

Risk management is defined in the Intravenous Nursing Standards of Practice as a "process that centers on identification, analysis, treatment and evaluation of renal and potential hazards." Just what type of risk do these hazards pose and what types of "real and potential hazards" are there? The first question is the easiest to answer.
Snake-Arm Robots – A New Tool for the Aerospace Industry (2003)

<div class="htmlview paragraph">This paper introduces a type of robot, called a snake-arm robot, which offers the potential to change aircraft assembly and maintenance processes in order to reduce costs and lead times.</div> <div class="htmlview paragraph">A snake-arm robot has many segments and belongs to the family of hyper-redundant robots. The appeal of this type of device is that a snake-arm uses its many segments, controlled by a nose-following algorithm, to reach into restricted access spaces in a minimally obtrusive manner.</div> <div class="htmlview paragraph">In addition to nose following, a second artifact of the <b>OC</b>Robotics design is the use of flexible rather than rigid segments. Whilst this improves the ability of the arm to reach into awkward spaces, it also means that the arm is compliant and has the potential to be used unguarded in human environments.</div> <div class="htmlview paragraph">Historically industrial robots have been developed for the automotive industry and are not widely used for aircraft assembly. This is partly because the challenges of aircraft manufacture and maintenance are quite dissimilar to those of the car industry. Differences include production volumes, size and range of components, process tolerances and the level of control over the working environment. The assembly of aircraft stubbornly remains a ‘craft industry’.</div> <div class="htmlview paragraph">If significant cost reductions are to be achieved through increased use of automation then process change needs to happen in parallel with the development of new tools and technologies. Whilst some of these technologies can be transferred from other sectors, other ideas need to be pulled through by the aircraft industry for the aircraft industry.</div> <div class="htmlview paragraph">This paper explains how snake-arm robots operate and identifies strengths that may be relevant to various aircraft assembly and maintenance procedures including inspection, cleaning, application of sealant, painting, laser welding, leak detection, NDT and riveting.</div> <div class="htmlview paragraph">The paper concludes with progress in the area of explosive ordnance disposal. This military application demonstrates key features of similar technology that could be applied to the aerospace industry.</div>
Two-photon spectroscopy of ultracold large molecules in planar supersonic expansions (1981)

The vibronic spectrum of ultracold fluorene is reported. (AIP)
Effects of gender and gonad status on N-methyl-N-nitrosourea-induced cataractogenesis and retinopathy in Lewis rats. (2006)

The presence of ovaries and female gender appear to be associated with greater severity of cataracts and retinopathy, respectively, but the severity of these diseases did not correlate with the serum hormone levels.
Morphing using curves and shape interpolation techniques (2002)

This paper presents solutions to the feature correspondence and feature interpolation problems in image morphing. The user specifies the correspondence between the source and the target images by drawing input curves on the features of the objects. The correspondence between these curves at the finest level (pixel level) is computed by optimizing a cost function. Based on this correspondence, the input curves are approximated by using Bezier curves. We represent the Bezier curves and the connections among them by using a "dependency graph". Feature interpolation is performed by interpolating the dependency graphs using the edge-angle blending technique. We also propose methods for controlling the transition rates of the shape and the color. We implemented the proposed algorithms in our morphing system which is based on the field morphing technique. From experimental results, our algorithms can generate a smooth morphing animation even when the objects in the source and the target images have different orientations. Also, the user's workload is reduced because the system includes an automatic feature correspondence computation.