gebhart/patrepeval huggingface dataset:
Combined action of metal and semiconductor catalysts (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCombined action of metal and semiconductor catalystsG. M. Schwab and K. KollerCite this: J. Am. Chem. Soc. 1968, 90, 12, 3078–3080Publication Date (Print):June 1, 1968Publication History Published online1 May 2002Published inissue 1 June 1968https://pubs.acs.org/doi/10.1021/ja01014a016https://doi.org/10.1021/ja01014a016research-articleACS PublicationsRequest reuse permissionsArticle Views389Altmetric-Citations55LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Early Results of Phase II Study Using OMS721 in Patients with Hematopoietic Stem Cell Transplant-Associated Thrombotic Microangiopathy (HCT-TMA) (2017)

Introduction: TMA is a potentially life-threatening complication of HCT currently managed largely by amelioration of inciting factors including avoidance of calcineurininhibitors and treatment of ongoing infections, as well as supportive measures such as hemodialysis. Patients who do not respond have poor prognosis. Plasma exchange has not shown efficacy and no other therapy is approved. Complement activation has been reported in the pathogenesis of HCT-TMA. OMS721 is a human monoclonal IgG4 inhibitor of mannan-binding lectin-associated serine protease-2 (MASP-2), the effector enzyme of the lectin pathway of complement activation. Here we report early results of OMS721 treatment in HCT-TMA patients. Methods: This is a Phase 2 uncontrolled, open-label, 3-stage study of OMS721 to assess safety, tolerability and clinical activity of OMS721 in patients with TMA (HCT-TMA, aHUS and TTP). Stage 1 included dose-escalation cohorts, Stage 2 expands disease-specific cohorts and Stage 3 provides optional extended treatment. For inclusion, patients with HCT-TMA should demonstrate thrombocytopenia and evidence of microangiopathic hemolytic anemia, and at least 2 weeks must have elapsed since changes in immunosuppressive treatment. HCT-TMA patients received OMS721 X *Dose is confidential.*Dose is confidential. mg/kg IV once weekly (Stage 1 up to 4 weeks and Stages 2 and 3 up to 8 weeks). Patients could receive additional half doses if given plasma therapy. Results: 5 HCT-TMA patients were enrolled; 2 patients entered Stage 1 and 3 patients entered Stages 2 and 3. All patients were adults and received HCT for hematological malignancies. Figure 1, Figure 2, Figure 3 provide the change from baseline in TMA variables. These figures provide data on all 5 patients, two of whom discontinued the study (1 each in Stage 1 and Stage 2, both after 2-3 weeks) with one subsequently relapsing and the other receiving palliative care.Figure 2LDH change from baseline over time.View Large Image Figure ViewerDownload Hi-res image Download (PPT)Figure 3Change in haptoglobin over time.View Large Image Figure ViewerDownload Hi-res image Download (PPT) Statistically significant improvement in LDH and haptoglobin were observed during treatment. Platelet count improved but did not reach statistical significance in this small number of patients. Of the 3 patients who completed treatment, 1 did not show improvement in creatinine but was receiving concomitant nephrotoxic agents; RRT was not required. Creatinine improved or remained normal in the other 2 patients. On extended follow up, 1 patient experienced graft failure and is awaiting a second transplant. The other 2 patients remain stable. OMS721 treatment was well tolerated with no safety concerns. Conclusions: OMS721 improved TMA markers in HCT patients who had not responded to conservative measures. No toxicity signals were observed during treatment. By inhibiting the lectin pathway, OMS721 may be beneficial in the treatment of HCT-TMA and further study is ongoing.
Current mirrors with low input and low output voltage requirements (2002)

High accuracy, high output resistance current mirrors are derived from conventional mirrors using MOS and bipolar DC level shifters. The modified structures have significantly reduced input and output voltage requirements. Experimental results of a CMOS test chip are shown that verify the proposed structures.
Fingolimod modulates microglial activation to augment markers of remyelination (2011)

The results presented indicate that modulation of S1P receptors can ameliorate pathological effectors associated with microglial activation leading to a subsequent increase in protein and morphological markers of remyelination. In addition, sphingosine-1-phosphate receptor 5 is implicated in promoting remyelination in vitro. This knowledge may be of benefit for treatment of chronic microglial inflammation in multiple sclerosis.
Immunological Unresponsiveness Induced by Cryptococcal Capsular Polysaccharide Assayed by the Hemolytic Plaque Technique (1972)

Numerous studies have suggested that cryptococcal capsular polysaccharide could induce an immunological paralysis. To investigate this possibility, mice were given various concentrations of purified cryptococcal polysaccharide and then 14 days later were challenge-immunized with the same material in Freund's incomplete adjuvant. Anticryptococcal agglutinin titers were determined at various periods after polysaccharide treatment and after challenge immunization. At the same periods the hemolytic plaque technique was used to determine the number of spleen cells capable of producing antibody against cryptococcal polysaccharide. The data indicated that there was a transitory immune response which preceded tolerance induction. In animals given the largest doses of polysaccharide, "in vivo" neutralization was responsible for low serum agglutinin titers during the transitory response. The capsular polysaccharide was considered to have induced immunological unresponsiveness at the highest concentration, because challenge immunization did not stimulate an increase in the number of plaque-forming cells (PFC). A sixfold increase in numbers of PFC was found in animals injected initially with the lowest concentration of polysaccharide. These results support the idea that tolerance was due to terminal differentiation without proliferation of the immunocompetent cells. The central failure of the immune mechanism which was apparent in the paralyzed mice was temporary under the conditions of this experiment.
A simplified theoretical method of determining the characteristics of a lifting rotor in forward flight (1941)

Theoretical derived expressions for the flapping, the thrust, the torque, and the profile drag-lift ratio of nonfeathering rotor with hinged, rectangular, linearly twisted blades are given as simple functions of the inflow velocity and the blade pitch. Representative values of the coefficients of each of the terms in these expressions are tabulated for a series of specified values of the tip-speed ratio. Analysis indicates that the tabulated values can be used to calculate, with reasonable accuracy, the characteristics of any rotor of conventional design.
Initiation of Spermatogenesis in Vitro1 (1964)

The in vitro effect of gonadotropins (FSH, HCG) and vitamins (A, E, C) on spermatogenesis was studied in organ cultures of 4-day-old rat testes. The techniques employed permitted long-term maintenance of basic tissue structure and survival of primitive germ and supporting cells. Addition of NIH-FSH-S-1 to the culture medium, in concentrations of 20, 50 or 100 μg/ml, resulted in changes of supporting cells compatible with maturation; however, formation of more mature germinal cells from primitive type A spermatogonia was not induced. Similar changes were produced by HCG (Follutein, Squibb) in a concentration of 100 μ/ml. Lower doses (20 or 50 μ/ml) had no effect. Differentiation of the germinal epithelium up to the stage of primary spermatocytes proceeded when the culture medium contained vitamins A (12 μ/ml), C (50 μg/ml) and E (120 Mg/ml). These data indicate that spermatogenesis can progress in vitro from the primitive germinal cell to the stage of primary spermatocytes in the absence of gonadotropins, providing vitamins A, E and C are present in the culture medium. (Endocrinology74: 788, 1964)
The prognostic significance of microvascular obstruction after myocardial infarction as defined by cardiovascular magnetic resonance (2005)

This editorial refers to ‘Sequelae of acute myocardial infarction regarding cardiac structure and function and their prognostic significance as assessed by magnetic resonance imaging’† by V. Hombach et al. , on page 549 

Cardiac magnetic resonance imaging (CMR) has evolved into an important imaging tool in the assessment of patients with myocardial infarction (MI), with or without reperfusion. CMR is a gold standard technique for measuring left ventricular volumes and global function.1 The technique of delayed contrast enhancement has been carefully validated in animal markers as a measure of infarct size.2 The presence of hypo-enhanced regions at the core of hyper-enhanced infarctions is a marker of microvascular obstruction (MO)3 and a predictor of lack of functional recovery in the infarct zone4 and poor cardiovascular outcome in the patient post-MI.5

The paper by Hombach et al. 6 is the largest report to date of these CMR techniques used in sequential fashion in patients with acute MI and thus is quite instructive regarding prognostic factors derived from CMR. These authors studied 110 patients at a mean of day 6 after acute MI, which is a relatively late initial time point as patients currently are typically discharged before day 6. Of the original 110 patients, 89 returned for follow-up imaging at an average of ∼9 months after MI. The remainder died ( n =7), refused follow-up ( n =11), or had … 

*Corresponding author. Tel: 434 243 6060; fax: 434 982 1618. E-mail address : ckramer{at}virginia.edu
Apatite Crystallites: Effects of Carbonate on Morphology (1967)

Carbonate is a substituent in the apatite structure; when present, it limits the size of the growing apatite crystals and so influences their shape that they grow more equiaxed than needle-like. The tendency for carbonate apatites to be equiaxed is related to the nature of the chemical bonds formed in the crystal. The interference of carbonate with the good crystallization of apatite, and its weakening effect on the bonds in the structure, increase the dissolution rate and the solubility, thereby presumably contributing to the susceptibility to caries of dental apatites containing carbonate.
Fast Global Image Smoothing Based on Weighted Least Squares (2014)

This paper presents an efficient technique for performing a spatially inhomogeneous edge-preserving image smoothing, called fast global smoother. Focusing on sparse Laplacian matrices consisting of a data term and a prior term (typically defined using four or eight neighbors for 2D image), our approach efficiently solves such global objective functions. In particular, we approximate the solution of the memory-and computation-intensive large linear system, defined over a d-dimensional spatial domain, by solving a sequence of 1D subsystems. Our separable implementation enables applying a linear-time tridiagonal matrix algorithm to solve d three-point Laplacian matrices iteratively. Our approach combines the best of two paradigms, i.e., efficient edge-preserving filters and optimization-based smoothing. Our method has a comparable runtime to the fast edge-preserving filters, but its global optimization formulation overcomes many limitations of the local filtering approaches. Our method also achieves high-quality results as the state-of-the-art optimization-based techniques, but runs ∼10-30 times faster. Besides, considering the flexibility in defining an objective function, we further propose generalized fast algorithms that perform Lγ norm smoothing (0 < γ < 2) and support an aggregated (robust) data term for handling imprecise data constraints. We demonstrate the effectiveness and efficiency of our techniques in a range of image processing and computer graphics applications.
Radiation dose calculation for Tc-99m HIDA in health and disease. (1981)

Radiation dose from Tc-99m HIDA has been calculated for normal subjects and for patients with various hepatobiliary diseases classified into four groups based on serum bilirubin level. The calculation was performed on biokinetic radioactivity data from blood, urine, liver, gallbladder, and intestines, using a biological approach that included a catenary model of the digestive organs. For normal subjects the critical organs were the gallbladder and the upper and lower large intestine, with doses of 910, 300, 200 mrad/mCi, respectively. The bone marrow, ovaries, and testes received 24, 62, and 4 mrad/mCi. For Group 4 patients with severe hepatobiliary disease (bilirubin greater than 10 mg/dl), the critical organs were the kidney, urinary bladder, and gallbladder, with doses of 130, 110, and 100 mrad/mCi. The bone marrow, ovaries, and testes received 9, 13, and 6 mrad/mCi. Thus the critical organs and overall radiation doses to organs change between health and disease.
1 /spl mu/m MOSFET VLSI technology. VII. Metal silicide interconnection technology - A future perspective (1979)

For pt.VI see ibid., vol.SC14, no.2, p.282 (1979). A major limitation of polycrystalline silicon as a gate material for VLSI applications is its limited conductivity which restricts its usefulness as an interconnection level. An alternative approach which combines a doped polycrystalline silicon layer with a high-conductivity metal silicide such as WSi/SUB 2/ (polycide) is described. Such polycide layers are demonstrated to provide at least an order of magnitude improvement in interconnection resistance relative to polycrystalline silicon while maintaining the reliability of the polycrystalline silicon gate and the ability to form passivating oxide layers under typical polycrystalline silicon processing conditions.
Reliable assay of extreme enantiomeric purity values by a new circular dichroism based HPLC detection system (2000)

A new sensitive, selective, and versatile circular dichroism (CD)-based HPLC detection system was used for the validation of the enantiomeric purity assay in the quality control of chiral drugs upon nonchiral stationary phases. The precision and the accuracy of the method were checked for selected samples showing values of the anisotropy factor on the order of 10(-1) to 10(-4). Very high accuracy has been obtained also in the case of extreme enantiomeric purity values (</=1% or >/=99% e.p.) and of a low anisotropy factor (g = 2 x 10(-4)) compound. The high selectivity of this detection system allows a selective monitoring of analytes in complex mixtures and makes the baseline stable.
Mariano Scarlata Fazio, La Successione Codicillare (1940)

Article Mariano Scarlata Fazio, La Successione Codicillare was published on August 1, 1940 in the journal Zeitschrift der Savigny-Stiftung für Rechtsgeschichte: Romanistische Abteilung (volume 60, issue 1).
N‐Doped Graphene Natively Grown on Hierarchical Ordered Porous Carbon for Enhanced Oxygen Reduction (2013)

A novel nitrogen doped hybrid material composed of in situ-formed graphene natively grown on hierarchical ordered porous carbon is prepared, which successfully combines the advantages of both materials, such as high surface area, high mass transfer, and high conductivity. The outstanding structural properties of the resultant material render it an excellent metal-free catalyst for electrochemical oxygen reduction.
A comparison of native ATM-multicast to IP-multicast with emphasis on mapping between the two (2002)

Given the growing use of ATM, there is great interest in migrating the protocols which run on today's common networking technologies to ATM. There is particular interest in running the IP protocol on top of ATM. This provides an easy bridge between current networking protocols and applications and future ATM-only protocols and applications One of the move recent IP protocols, IP-multicast, has been used for video-conferencing over the Internet. This application is a good example of a current technology that could benefit from the higher bandwidths offered by ATM. IP-multicast provides a method for sending copies of packets to every member of a group simply by sending the packet to the group's address. In order to perform this IP-multicasting on top of ATM efficiently, it is expected that a mapping of IP multicast subnet functionality to ATM must be developed. The paper examines current developments in ATM and their relation to IP-multicast in an attempt to identify schemes for achieving IP-multicast subnet functionality in ATM.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The Presence of Humic Substances and DNA in RNA Extracts Affects Hybridization Results (2000)

RNA extracts obtained from environmental samples are frequently contaminated with coextracted humic substances and DNA. It was demonstrated that the response in rRNA-targeted oligonucleotide probe hybridizations decreased as the concentrations of humic substances and DNA in RNA extracts increased. The decrease in hybridization signal in the presence of humic substances appeared to be due to saturation of the hybridization membrane with humic substances, resulting in a lower amount of target rRNA bound to the membrane. The decrease in hybridization response in the presence of low amounts of DNA may be the result of reduced rRNA target accessibility. The presence of high amounts of DNA in RNA extracts resulted in membrane saturation. Consistent with the observations for DNA contamination, the addition of poly(A) to RNA extracts, a common practice used to prepare RNA dilutions for membrane blotting, also reduced hybridization signals, likely because of reduced target accessibility and membrane saturation effects.
INVESTIGATION OF DATA EXCHANGE REQUIREMENTS FOR COOPERATIVE GRID PLANNING AND OPERATION (2011)

IEC 61970 and 61968 together referred as Common Information Model (CIM), are proposed to facilitate integration of EMS applications with proprietary data formats and information exchange between control centers. To use Information and Communication Technology (ICT) systems in an optimized manner, it is necessary to partition the potentially voluminous data into subsets given their sources, expected exchange frequency, and subscribing applications. In response to these requirements, the concept of CIM profiles is brought up by CIMug. In this paper, functions illustrating the dependency between exchange data volume and basic grid parameters for each data profile are presented. A CIM/XML/RDFfile for a commonly available 40 bus test system modeled according to CIM 13 together with examples provided by standards are used as references. The method is validated by estimating the CIM/XML/RDF file sizes of similarly available 100 bus and 60 bus test systems. The contribution of this paper is that it provides ICT system designers with a means to estimate the corresponding requirements for various CIM based data exchange scenarios. The estimations are performed based on commonly known grid parameters such as number of buses, branches, generators, transformers and loads.
Copper-Catalyzed Electrophilic Amination of Diorganozinc Reagents (2004)

The copper-catalyzed electrophilic amination of diorganozinc reagents employing O-acyl N,N-dialkyl hydroxylamine derivatives as aminating agents is described. This reaction offers a general method for the preparation of tertiary amines in high yields and is noteworthy for its convenience both in terms of reaction conditions employed (room temperature, </=1 h) and ease of product isolation (acid/base extractive workup).
Tn<i>10 tet</i>operator mutations affecting Tet repressor recognition (1986)

The effect of single base pair alterations of the Tn10 encoded tet operator on recognition of Tet repressor was studied in vivo using a repressor titration system and in vitro by dissociation rate determinations of the respective complexes. Both methods reveal that the two operators, O1 and O2, which are in a tandem arrangement in the wild type, are recognized with a two-fold different affinity when separated. Studies on synthetic operator sequences indicate that the Tet repressor binds with higher affinity to the non-palindromic O2 wildtype than to the respective palindromic sequences. The in vivo repressor titration system links the expression of lacZ to the affinity of tet operator to Tet repressor. It was used to isolate tet operator mutations with reduced affinity to the repressor. The in vivo and in vitro obtained results with these mutants agree quantitatively and indicate, that the GC base pairs at positions 2, 6, and 8 are involved in interaction with the Tet repressor. Their importance for recognition decreases in that order. Transitions at position 7 of the tet operator show smaller effects on recognition than transversions.
Fatigue of Solder Joints in Surface Mount Devices (1988)

Lifetime studies of a 16 I/O surface-mounted solder joint array undergoing isothermal cyclic fatigue in torsion shear under fixed plastic strain range show a strong correlation with creep fatigue and a creep-cracking mechanism. Experimental lifetime data follow an inverse dependence on matrix creep. Experimental measurement of the steady-state shear creep rate versus shear stress defines the creep characteristic that is sensitive to changes in metallurgical structure. The amounts of grain boundary and matrix creep taking place during a fatigue cycle are derived from experimental creep data combined with stress-strain hysteresis data obtained in steady-state cycling. Initially, thicker solder joints have a larger grain size than thinner solder joints, giving more matrix creep during fatigue and a faster failure rate. Fatigue increases the mean grain size of the solder joint as determined by the creep-rate-versus-stress characteristic and microstructure. Effects of grain size and joint thickness on lifetime are discussed. A maximum in the creep fatigue rate occurs at 333 K (60°C).
LSM-Based Storage and Indexing (2015)

With the social-media data explosion, near real-time queries, particularly those of a spatio-temporal nature, can be challenging. In this paper, we show how to efficiently answer queries that target recent data within very large data sets. We describe a solution that exploits a natural partitioning property that LSM-based indexes have for components, allowing us to filter out many components when answering queries. Our solution is generalizable to any LSM-based index structure, and can be applied not just on temporal fields (e.g., based on recency), but on any "time-correlated fields" such as Universally Unique Identifiers (UUIDs), user-provided integer ids, etc. We have implemented and experimentally evaluated the solution in the context of the AsterixDB system.