gebhart/patrepeval huggingface dataset:
Interference of enantiomers of lofexidine with alpha-adrenoceptors. (1985)

Some alpha-adrenoceptor-mediated cardiovascular activities and alpha-adrenoceptor binding affinities for (+)- and (-)-lofexidine (Dexlofexidine and Levlofexidine) have been studied in comparison with racemic lofexidine. In pithed normotensive rats, i.v. (-)-lofexidine elicited pressor effects at doses (0.1-30 micrograms/kg), which were approximately 20 times lower than those of the (+)-isomer. Both yohimbine and prazosin in selective amounts of 1.0 and 0.1 mg/kg (i.v., -15 min), respectively, attenuated the increase in diastolic pressure induced by (+/-)-, (+)- and (-)-lofexidine, showing the involvement of alpha 1- as well as alpha 2-adrenoceptors in the vasopressor responses. No differences were observed in the sensitivity of the pressor effects of the (+)- and (-)-enantiomers to blockade by either yohimbine or prazosin. Following i.v. administration to pentobarbitone-anaesthetized normotensive rats, (-)-lofexidine (0.5-5.0 micrograms/kg) was found about 20 times more effective than the dextrorotatory isomer in decreasing mean arterial pressure and heart rate. The increase in heart rate evoked by electrical stimulation in pithed rats was dose-dependently reduced by (+/-)-, (-)- and (+)-lofexidine, the (-)-isomer being about 30 times more potent than the (+)-isomer. Similarly, the electrical stimulation-induced increase in diastolic pressure was also most effectively impaired by the laevorotatory enantiomer of lofexidine. (-)-Lofexidine showed an approximately 9-fold higher affinity than (+)-lofexidine for the alpha 2-adrenoceptor-like binding sites in rat brain membranes identified by [3H]-clonidine and was 4 times more potent at displacing [3H]-prazosin from alpha 1-adrenoceptors. It is concluded that the alpha-adrenoceptor activity of lofexidine resides predominantly in the (-)-isomer. The isomeric activity ratio of the enantiomers of lofexidine (about 20-fold) is higher than normally found for other imidazolines.
A knock-out model of paroxysmal nocturnal hemoglobinuria: Pig-a(-) hematopoiesis is reconstituted following intercellular transfer of GPI-anchored proteins. (1996)

We created a "knockout" embryonic stem cell via targeted disruption of the phosphatidylinositol glycan class A (Pig-a) gene, resulting in loss of expression of cell surface glycosyl phosphatidylinositol-anchored proteins and reproducing the mutant phenotype of the human disease paroxysmal nocturnal hemoglobinuria. Morphogenesis of Pig-a- embryoid bodies (EB) in vitro was grossly aberrant and, unlike EB derived from normal embryonic stem cells, Pig-A EB produced no secondary hematopoietic colonies. Chimeric EB composed of control plus Pig-A- cells, however, appeared normal, and hematopoiesis from knock-out cells was reconstituted. Transfer in situ of glycosyl phosphatidylinositol-anchored proteins from normal to knock-out cells was demonstrated by two-color fluorescent analysis, suggesting a possible mechanism for these functional effects. Hematopoietic cells with mutated PIG-A genes in humans with paroxysmal nocturnal hemoglobinuria may be subject to comparable pathophysiologic processes and amenable to similar therapeutic protein transfer.
Functional genomics analysis of foliar condensed tannin and phenolic glycoside regulation in natural cottonwood hybrids (2005)

Regulation of leaf condensed tannins (CT) and salicylate-derived phenolic glycosides (PG) in fast- and slow-growing cottonwood backcrosses was analyzed by metabolic profiling and cDNA microarray hybridization. Seven hybrid lines of Populus fremontii L. and P. angustifolia James exhibiting growth/CT-PG phenotypes ranging from fast/low (Lines 18 and 1979) to slow/high (Lines 1012 and RL2) and intermediate (Lines NUL, 3200 and RM5) were investigated. Methanol-extractable leaf metabolites were analyzed by gas chromatography-mass spectrometry, and the results evaluated by principal component analysis. The hybrid lines formed separate clusters based on their primary metabolite profiles, with cluster arrangement also reflecting differences in CT-PG phenotype. Nitrogen (N) supply was manipulated to alter CT-PG partitioning and to obtain molecular insights into how primary metabolism interfaces with CT-PG accumulation. Three backcross lines (RM5, 1012, 18) exhibiting differential CT-PG responses to a 10-day hydroponic N-deprivation treatment were chosen for metabolite and gene expression analyses. The fast- growing Line 18 showed a minimal CT-PG response to N deprivation, and a reduction in photosynthetic gene expression. Line 1012 exhibited a strong phenylpropanoid response to N deprivation, including a doubling in phenylalanine ammonia-lyase (PAL) gene expression, and a shift from CT accumulation in the absence of stress toward PG accumulation under N-deprivation conditions. Amino acid concentrations were depressed in Lines 18 and 1012, as was expression of nitrate-sensitive genes coding for transketolase (TK), and malate dehydrogenase (MDH). Genes associated with protein synthesis and fate were down-regulated in Line 1012 but not in Line 18. Line RM5 exhibited a comparatively large increase in CT in response to N deprivation, but did not sustain decreases in amino acid concentrations, or changes in PAL, TK or MDH gene expression. Molecular characterization of the variable CT-PG responses shows promise for the identification and future testing of candidate genes for CT-PG trait selection or manipulation.
Kit-of-Parts: A Review of Object-Oriented Construction Techniques (1999)

Kit-of-Parts: A Review of Object-Oriented Construction Techniques A. Scott Howe, Ismau Ishii, Tomohiro Yoshida Pages 165-172 (1999 Proceedings of the 16th ISARC, Madrid, Spain, ISSN 2413-5844) Abstract: In pursuing construction and design concepts apporpriate for the information age,the authors have considered kit-of-parts theory.A kit-of-parts is a collection of discrete building components that are preengineered and designed to be assembled in a variety of ways to define a finished building.Since a well designed component can be mass-produced and used over and over again,fabrication processes can be worked out in advance for real-time manufacturing and automated assembly.This paper briefly traces the history of kit-of-parts construction techniques and categories some current methods from an architectural design perspective.Four categories of kit-of-parts systems are:JOINT-BASED,PANEL BASED,MODULE BASED and SPECIAL CONSTRUCTION.The paper concludes with descriptions of case study design of investigations conducted by the authors which demonstrate the advantage of pursuing kit-of-parts concepts in conjuction with architectural design processes and automated construction applications. Keywords: Kit-of-parts; architectural design; automated construction; design grammar DOI: https://doi.org/10.22260/ISARC1999/0025 Download fulltext Download BibTex Download Endnote (RIS) TeX Import to Mendeley
Cost-Effective Integration of RF-LDMOS Transistors in 0.13 &#956;m CMOS Technology (2009)

Abstract - A new cost-effective concept for RF-LDMOS transistors in a standard 0.13 mum CMOS technology without process modifications is demonstrated. For the integration of the devices only standard implants of the RF-CMOS process are used. The devices have gate length of 0.35 mum and share the 7 nm gate oxide of the 3.3 V CMOS I/O devices. A breakdown voltage of 19 V and f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</sub> /f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">MAX</sub> values of 25 GHz/55 GHz, respectively are obtained.
Beneficial innate signaling interference for antibacterial responses by a Toll-like receptor–mediated enhancement of the MKP-IRF3 axis (2013)

A major function of innate immune receptors is to recognize pathogen-associated molecular patterns and then evoke immune responses appropriate to the nature of the invading pathogen(s). Because innate immune cells express various types of these receptors, distinct combinations of signaling pathways are activated in response to a given pathogen. Although the conventional wisdom is that these signaling pathways cooperate with one another to ensure an effective host response, a more nuanced view recognizes antagonism between the individual pathways, where the attenuation of a signaling pathway(s) by others may shape the immune response. In this study, we show that, on Listeria monocytogenes infection, Toll-like receptor-triggered MyD88 signaling pathways suppress type I IFN gene induction, which is detrimental to macrophage bactericidal activity. These pathways target and suppress the IFN regulatory factor 3 (IRF3) transcription factor that is activated by the stimulator of IFN genes-TANK-binding kinase-1 kinase pathway. We also provide evidence for the involvement of the MAPK phosphatase family members, which renders IRF3 hypophosphorylated on Toll-like receptor signaling by enhancing the formation of an MAPK phosphatase-IRF3-TANK-binding kinase-1 ternary complex. This study, therefore, reveals a hitherto unrecognized and important contribution of a beneficial innate signaling interference against bacterial infections.
Modified Sigma Filter For Processing Images Corrupted By Multiplicative And Impulsive Noise (1996)

Publication in the conference proceedings of EUSIPCO, Trieste, Italy, 1996
Structural characterization of Ba<sub>0.5</sub>Sr<sub>0.5</sub>,TiO<sub>3</sub> on RuO<sub>2</sub> prepared by pulsed laser deposition (1997)

Abstract Highly conductive RuO2 thin films were epitaxially grown on (100) LaAlO3 substrates by pulsed laser deposition. The RuO2 film deposited with optimized conditions was (h00) oriented normal to the substrate surface with strong in-plane orientation. The RuO2 thin films deposited at temperatures of above 500 °C demonstrated a room-temperature resistivity of 35 ± 2 μΩ-cm. The Ba0.5Sr0.5TiO3 thin films deposited on epi-RuO2 showed pure (111) orientation normal to the substrate surface, and exhibited dielectric constant above 600 and dielectric loss of 0.03–0.05 at 100 kHz under zero dc bias.
Control of the Particle Properties of a Drug Substance by Crystallization Engineering and the Effect on Drug Product Formulation (2005)

A study of the process−property−performance relationship of a Bristol-Myers Squibb drug substance led to successful development of crystallization and drying processes that produce crystals with desired and consistent physical properties. A controlled crystallization technique was developed to obtain well-defined, large crystals with a narrow particle size distribution. This crystallization process provided a less compressible filter cake for effective cake washing and deliquoring and afforded an easily dried product with desired powder properties. To preserve the quality of the crystals during drying, a drying protocol using low shear agitation was developed. This protocol prevented crystal attrition during drying, which was shown to adversely affect the formulation process and, thus, drug product performance. API crystals prepared by this method consistently resulted in excellent formulation processing and drug product performance.
A Novel Silicon Schottky Diode for NLTL Applications (2005)

The design and simulation of a novel silicon Schottky diode for nonlinear transmission line (NLTL) applications is discussed in this paper. The Schottky diode was fabricated on a novel silicon-on-silicide-on-insulator (SSOI) substrate for minimized series resistance. Ion implantation technology was used as a low-cost alternative to molecular beam epitaxy to approximate the delta (/spl delta/) doping profile, which results in strong nonlinear CV characteristics. The equivalent circuit model of the Schottky diode under reverse bias conditions was extracted from the S-parameter measurement performed on the diode. The measured CV characteristics show strong nonlinearity, the junction capacitance varies from 182 to 47.5 fF as the reverse bias voltage is varied from 0 to -5 V. A parasitic inductance of 40 pH was measured for the silicon Schottky diode, which is much smaller than a comparable sized GaAs Schottky diode. This small inductance is an advantage for the silicon Schottky diode offering improvement in the silicon NLTL performance.
Development of a questionnaire to assess the relative subjective benefits of presbyopia correction (2011)

Results show the NAVQ is a reliable, valid instrument that can be incorporated into the evaluation of presbyopic corrections.
Genetic deletion of trkB.T1 increases neuromuscular function (2011)

Neurotrophin-dependent activation of the tyrosine kinase receptor trkB.FL modulates neuromuscular synapse maintenance and function; however, it is unclear what role the alternative splice variant, truncated trkB (trkB.T1), may have in the peripheral neuromuscular axis. We examined this question in trkB.T1 null mice and demonstrate that in vivo neuromuscular performance and nerve-evoked muscle tension are significantly increased. In vitro assays indicated that the gain-in-function in trkB.T1(-/-) animals resulted specifically from an increased muscle contractility, and increased electrically evoked calcium release. In the trkB.T1 null muscle, we identified an increase in Akt activation in resting muscle as well as a significant increase in trkB.FL and Akt activation in response to contractile activity. On the basis of these findings, we conclude that the trkB signaling pathway might represent a novel target for intervention across diseases characterized by deficits in neuromuscular function.
Generalized Kraft Inequality and Arithmetic Coding (1976)

Algorithms for encoding and decoding finite strings over a finite alphabet are described. The coding operations are arithmetic involving rational numbers l <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">i</inf> as parameters such that ∑ <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">i</inf> 2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">−l</sup> i≤2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">−ε</sup> . This coding technique requires no blocking, and the per-symbol length of the encoded string approaches the associated entropy within ε. The coding speed is comparable to that of conventional coding methods.
Comparison of charge control technologies for advanced high current ion implantation systems (2003)

Reduction of gate oxide thickness with device design rule dictates increasingly precise compensation of ion beam positive space charge with electrons and reduction of beam potential. In the present work we investigate charging damage to thin gate oxides due to high current ion implants performed on implanters equipped with different types of hardware for beam space charge neutralization. We are comparing GSD-200/E/sup 2/ high current implanters equipped with either Secondary Electron Flood (SEF) or Plasma Electron Flood (PEF) and the ULE2 ultra-low energy high current implanter, which employs the latest charge control technology (Plasma Cell) introduced by Eaton. Gate-antenna type capacitors and SPIDER structures were used to evaluate beam neutralization. We performed charge-to-breakdown (Q/sub BD/) measurements on MOS capacitors to evaluate gate oxide wearout, and V/sub t/ and charge pumping measurements on SPIDER structures to measure concentration of charge traps generated within the oxide and at the Si/SiO/sub 2/ interface. Good correlation of the data collected from Q/sub BD/ charge pumping, device parametrics (V/sub t/) measurements, and readings of in situ beam potential monitors is demonstrated. Experimental results demonstrate that Plasma Cell technology employed in the ULE2 family of ultra-low energy implanters under optimum conditions provides the best charging performance and allows achievement of minimal gate oxide wearout and lowest concentration of charge traps at the gate stack SiSiO/sub 2/ interface in the SPIDER structures.
Development of disease modifying drugs for dementia—focusing on anti-tau drugs— (2014)

In an aging society, the number of people with dementia has increased. Since Alzheimer's disease and a part of frontotemporal lober degeneration (FTLD-tau) have abnormal tau pathology in brain, these are called Tauopathy. Previously results showed that occurrence of abnormal tau has been involved in development of cognitive dysfunction and neuronal loss indicating that tau-focused drug (inhibitors of tau hyperphosphorylation, tau aggregation and so on) may be valuable in therapy for Tauopathy. This study collated data of clinical trials that evaluated tau-based drugs to help development of agent for dementia drugs in future. We discovered a novel tau aggregation inhibitor, and elucidated the inhibitory mechanism of the compound on tau aggregation. These results suggest that tau aggregation is an important target for therapy of dementia.
Gearing resource-poor mobile devices with powerful clouds: architectures, challenges, and applications (2013)

Mobile cloud computing, with its promise to meet the urgent need for richer applications and services of resource-constrained mobile devices, is emerging as a new computing paradigm and has recently attracted significant attention. However, there is no clear definition and no well defined scope for mobile cloud computing due to commercial hype, and diverse ways of combining cloud computing and mobile applications. This article makes the first attempt to present a survey of mobile cloud computing from the perspective of its intended usages. Specifically, we introduce three common mobile cloud architectures and classify comprehensive existing work into two fundamental categories: computation offloading and capability extending. Considering the energy bottleneck and user context of mobile devices, we discuss the research challenges and opportunities of introducing cloud computing to assist mobile devices, including energy-efficient interactions, virtual machine migration overhead, privacy, and security. Moreover, we demonstrate three real-world applications enabled by mobile cloud computing, in order to stimulate further discussion and development of this emerging field.
Synthesis of plucked-string tones by physical modeling with recurrent neural networks (2002)

Physical modeling music synthesis techniques by simulating the vibrations of acoustic instruments are becoming more and more popular in the recent years. In the past few years, trying to find those appropriate parameters in order to make the synthesis result sound close to a specific instrument has been a very difficult problem. Various try-and-error methods based on frequency domain and time domain approaches were used mostly. In this paper, we propose a systematic analysis/synthesis model called the Scattering Recurrent Network (SRN) which is capable of modeling the dynamics of a plucked string and synthesizing tones which are very close to the tones produced by the same string. The sound quality is superior to both FM and Wavetable synthesis techniques.
Measurement of Optical Activity: New Approaches (1963)

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Planar RF induction plasma coupling efficiency (1994)

The radiofrequency power coupling efficiency of a planar induction source is determined by measurement of the power dissipated in the matching network and inductive coupler. Typically one finds the radiofrequency current to vary between 20 and 60 A (root mean square). The equivalent resistance of the coupling network is determined to be 0.09 Omega , and power coupling efficiency to the plasma is therefore found to be 70-90% with the remaining power lost to ohmic heating of the circuit elements. The efficiency is highest when the plasma-to-inductor distance is least since the increased mutual inductance reduces the radiofrequency inductor current and, hence, ohmic losses. Efficiency of power coupling is nearly constant as a function of radiofrequency power between 200 and 2000 W. Somewhat larger currents are required to sustain a discharge at lower pressures (about 1 mTorr) or when the plasma is not magnetically confined, giving rise to lower coupling efficiencies.
Editorial (1996)

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Comparison of biochemistry and diet in patients with enterocystoplasty who do and do not form stones (2008)

Apparently the use of bowel in the urinary tract does not alone increase the risk of urolithiasis. Patients in group 1 were more prone due to the constituents of urine and possibly their dietary habits. This implies that with adequate fluid intake and eating a healthy balanced diet, the risk of urolithiasis can be reduced in patients with enterocystoplasty, as with idiopathic stone formers.
Epitaxially-stacked multiple-active-region 1.55μm lasers for increased differential efficiency (1999)

Semiconductor lasers emitting at 1.55 μm with external differential efficiencies &gt;1 have been created by monolithically connecting several active regions in series within a single optical waveguide. This is accomplished by epitaxially stacking a number of p–i–n multiquantum well active regions with intermediate n++–p++ back diodes, which enable the entire terminal current to flow through each active region stages in series. Such lasers should also improve the impedance match as well as provide for low-noise, high-efficiency microwave links.
Food Increases the Bioavailability of Tolterodine but Not Effective Exposure (2001)

The objective of this study was to investigate the influence of food on the pharmacokinetics of tolterodine, its active 5-hydroxymethyl metabolite (5-HM), and exposure to the active moiety (sum of unbound tolterodine + 5-HM) in healthy volunteers. Serum concentrations of tolterodine and 5-HM were measured for up to 12 hours after a single oral dose (2 mg) of tolterodine L-tartrate, administered either on an empty stomach or with a standardized medium-fat breakfast. All 23 subjects completing the study were classified as extensive metabolizers (phenotyped with debrisoquine). Pharmacokinetic data on tolterodine and the active moiety were evaluable for 22 subjects; all completing subjects were evaluable for 5-HM pharmacokinetics. Based on Cmax and AUC(infinity) ratios, relative bioavailability of tolterodine in the presence of food was 1.49 (90% confidence interval [CI], 1.35-1.71) and 1.53 (1.35-1.72), respectively. The pharmacokinetics of 5-HM and the active moiety were unaffected by food, as were the rates of drug absorption and terminal half-lives of tolterodine and 5-HM. Given that bioequivalence was observed for the active moiety underfed and fasting conditions, the authors concluded that coadministration of tolterodine with food is not expected to have any clinically relevant effects.
Magnetic resonance lung function – a breakthrough for lung imaging and functional assessment? A phantom study and clinical trial (2006)

With this method, ventilation defects can be diagnosed long before any imaging or pulmonary function test will indicate disease. This surprisingly simple approach could easily be incorporated in clinical routine and may be a breakthrough for lung imaging and functional assessment.
Synthesis of Stable Seleno[3,4-<i>b</i>]quinoxaline Derivatives (2003)

[reaction: see text]. The unstable seleno[2,3-b]quinoxoline was generated and functionalized in situ to give the stable dialdehyde and diester derivatives. The dicyano compound was made in several steps from biscyanomethyl selenide and was found to be very stable.