gebhart/patrepeval huggingface dataset:
Restoration of β-Adrenergic Receptor Signaling and Contractile Function in Heart Failure by Disruption of the βARK1/Phosphoinositide 3-Kinase Complex (2005)

These data indicate that the heart failure state is associated with a maladaptive redistribution of betaARs away from the plasma membrane that can be counteracted through a strategy that targets the betaARK1/PI3K complex.
Sparsity-Based Pixel Super Resolution for Lens-Free Digital In-line Holography (2016)

Lens-free digital in-line holography (LDIH) is a promising technology for portable, wide field-of-view imaging. Its resolution, however, is limited by the inherent pixel size of an imaging device. Here we present a new computational approach to achieve sub-pixel resolution for LDIH. The developed method is a sparsity-based reconstruction with the capability to handle the non-linear nature of LDIH. We systematically characterized the algorithm through simulation and LDIH imaging studies. The method achieved the spatial resolution down to one-third of the pixel size, while requiring only single-frame imaging without any hardware modifications. This new approach can be used as a general framework to enhance the resolution in nonlinear holographic systems.
Automatic Quantitative Radiometric Assay of Bacterial Metabolism (1976)

In a two-compartment scintillation vial, suspensions of bacteria were cultured with 1 muCi of [U-14C] glucose and the released 14C02 was measured continuously, cumulatively, and automatically in a liquid-scintillation counter modified to maintain sample temperature at 37 degrees C. We could follow the metabolism of bacterial populations through their early phase of exponential growth with good precision. The data were obtained conveniently, with use of conventional reagents, glassware, and counting equipment. From analysis of the exponential portion of the curves for cumulative activity vs. time, we could measure cell replication rate precisely in units of time. The resulting values were demonstrably independent of some common experimental variables, including the number of bacteria in the inoculum and counting system sensitivity. Sensitivity of the bacteria to antibiotics was measured to within a few percent by noting the relative prolongation of replication time in the presence of those inhibitors. The digital data from the scintillation counter are susceptible to on- or off-line computer analysis, thus providing the prospect for a totally-automated analytical system. The method shows promise for the mechanized quantitative analysis of bacterial growth, and its inhibition.
Reform of income tax in Australia: A long-term agenda (2005)

1 It is argued that a gap of five percentage points between the average income tax rate and the company tax rate would be sufficient to eliminate the construction of elaborate systems to shift income from one system to the other.
An RF-adaptive array antenna incorporated in a MIMO receiver under interference (2005)

In this paper, incorporation of an RF-adaptive array antenna (RF-AAA) is proposed on each receive branch in a multiple-input multiple-output (MIMO) receiver to achieve interference suppression. A criterion is shown for maximizing the output signal-to-interference-plus-noise ratio (SINR) in the RF-AAA with amplitude and phase adjusts. The performance is roughly evaluated with no amplitude adjust and a four-bit phase shift. Computer simulation verifies that the RF-AAA improves the capacity of the MIMO system and the bit-error rate (BER) performance of its receiver by suppressing interference, as the number of RF-AAA elements increases. However, diversity gain is not obtained as the number of RF-AAA elements increases, and the impact of interference suppression is seriously degraded as the angular spread of the interference increases.
Differential Incorporation of Thymidylate Analogues into DNA by DNA Polymerase   and by DNA Polymerases Specified by Two Herpes Simplex Viruses (1982)

Several triphosphates (TP) of 5-substituted deoxyuridine (dU), like 5-ethyl (Et), 5-n-propyl (n-Pr), 5-iso-propyl (iso-Pr), 5-n-hexyl (n-Hx), and 5-trifluorothymidine (F3-dT) were used as substrates for HeLa DNA polymerase alpha and for two herpes simplex virus (HSV)-coded DNA polymerases isolated from HeLa cells infected with HSV-1, strain C42 (wild-type), or its mutant resistant to phosphonoformate (PFAr). All polymerases were purified up to the DNA-cellulose column step and they showed comparable specific activities. The incorporation into DNA studied with all the alkyl analogues of dUTP is several times higher with the virus enzymes than with DNA polymerase alpha. The DNA polymerase of the mutant virus incorporates dUTP analogues to a lower extent than the wild-type polymerase. The two virus enzymes also differ in the Km and Vmax values for different substrates, indicating that the mutation to PFAr has affected the structure of the virus DNA polymerase. Surprisingly, all three enzymes use F3-dTTP as substrate for DNA synthesis to an equal but limited extent.
Detection of Lema bilineata Germar (Coleoptera: Chrysomelidae) in Australia. (2010)

The South American chrysomelid Lema bilineata Germar is recorded for the first time in Australia. Adults and larvae were found feeding on Prairie Ground Cherry (Physalis viscosa L.) in an open greenhouse in Wagga Wagga in southern New South Wales during November 2008. The greenhouse population was eradicated immediately after it was recognised as a potential biosecurity threat but further detections of L. bilineata were subsequently made in the Cootamundra area. L. bilineata feeds on a range of solanaceous plants including both crop species and weeds, and has potential negative and positive impacts on agriculture in south-eastern Australia.
Cortactin-Src Kinase Signaling Pathway Is Involved in N-syndecan-dependent Neurite Outgrowth (1998)

N-syndecan (syndecan-3) was previously isolated as a cell surface receptor for heparin-binding growth-associated molecule (HB-GAM) and suggested to mediate the neurite growth-promoting signal from cell matrix-bound HB-GAM to the cytoskeleton of neurites. However, it is unclear whether N-syndecan would possess independent signaling capacity in neurite growth or in related cell differentiation phenomena. In the present study, we have transfected N18 neuroblastoma cells with a rat N-syndecan cDNA and show that N-syndecan transfection clearly enhances HB-GAM-dependent neurite growth and that the transfected N-syndecan distributes to the growth cones and the filopodia of the neurites. The N-syndecan-dependent neurite outgrowth is inhibited by the tyrosine kinase inhibitors herbimycin A and PP1. Biochemical studies show that a kinase activity, together with its substrate(s), binds specifically to the cytosolic moiety of N-syndecan immobilized to an affinity column. Western blotting reveals both c-Src and Fyn in the active fractions. In addition, cortactin, tubulin, and a 30-kDa protein are identified in the kinase-active fractions that bind to the cytosolic moiety of N-syndecan. Ligation of N-syndecan in the transfected cells by HB-GAM increases phosphorylation of c-Src and cortactin. We suggest that N-syndecan binds a protein complex containing Src family tyrosine kinases and their substrates and that N-syndecan acts as a neurite outgrowth receptor via the Src kinase-cortactin pathway.
Occupational Therapists (1994)

Occupational therapists (OTs) do a lot more than just keep people ‘occupied’.
Synthesis of benzoquinone-1,4-aldehyde diacetate (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of benzoquinone-1,4-aldehyde diacetateDurvasula V. Rao, Henri Ulrich, and Adnan A. R. SayighCite this: J. Org. Chem. 1975, 40, 17, 2548–2549Publication Date (Print):August 1, 1975Publication History Published online1 May 2002Published inissue 1 August 1975https://pubs.acs.org/doi/10.1021/jo00905a035https://doi.org/10.1021/jo00905a035research-articleACS PublicationsRequest reuse permissionsArticle Views262Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Characterization and comparison of modern layer-2 ethernet survivability protocols (2005)

Ensuring the survivability and recoverability of computer networks under fault conditions requires the selection and testing of the appropriate protocols that handle failure events. While testing using the actual networking equipment is the most accurate, it is not always feasible due to cost and time constraints. Instead, simulation can be used. However, results may not always represent actual network behaviors. This study first looks at selected layer-2 Ethernet protocols available for increasing the survivability of a network, i.e., spanning tree protocol and rapid spanning tree protocol. These protocols are tested on two small live networks and then via simulation. After the simulations are validated by these tests, the protocol's performance is then characterized for larger topologies.
The Expanding World of Tissue Engineering: The Building Blocks and New Applications of Tissue Engineered Constructs (2013)

The field of tissue engineering has been growing in the recent years as more products have made it to the market and as new uses for the engineered tissues have emerged, motivating many researchers to engage in this multidisciplinary field of research. Engineered tissues are now not only considered as end products for regenerative medicine, but also have emerged as enabling technologies for other fields of research ranging from drug discovery to biorobotics. This widespread use necessitates a variety of methodologies for production of tissue engineered constructs. In this review, these methods together with their non-clinical applications will be described. First, we will focus on novel materials used in tissue engineering scaffolds; such as recombinant proteins and synthetic, self assembling polypeptides. The recent advances in the modular tissue engineering area will be discussed. Then scaffold-free production methods, based on either cell sheets or cell aggregates will be described. Cell sources used in tissue engineering and new methods that provide improved control over cell behavior such as pathway engineering and biomimetic microenvironments for directing cell differentiation will be discussed. Finally, we will summarize the emerging uses of engineered constructs such as model tissues for drug discovery, cancer research and biorobotics applications.
Micro-ecology of the Nasopharyngeal Bacterial Flora in Otitis-prone and Non-otitis-prone Children (1993)

The quantitative bacteriology of the adenoid was studied in otitis-prone and non-otitis-prone children. alpha-hemolytic Streptococci (Viridans Streptococci) appeared to be predominant normal flora in the healthy nasopharynx. There was a decrease in alpha-hemolytic Streptococci in the otitis-prone child compared to the non-otitis-prone child. Concomitantly, there appears to be an increase in both nontypable Haemophilus influenzae (NTHI) and S. pneumoniae in the nasopharyngeal flora in the otitis-prone child. The mechanisms responsible for this alteration of the micro-ecology of bacteria of the nasopharynx may be related, in part, to factors that alter mucociliary function. These factors could be viral infection, allergy, local and systemic immunological deficiency and the indiscriminate use of antibiotics. An understanding of the relationship between the normal flora and the potential pathogens may be important in the understanding of both the pathogenesis of otitis media (OM) and possibly the treatment of this disease entity.
<title>Transform coding of digital images using variable block-size DCT with adaptive thresholding and quantization</title> (1990)

Discrete cosine transform (DCT) coding has been emerging as a key element for image data compression. Conventional DCT coding algorithms which treat all the image areas indiscriminately unfortunately give nonuniform image quality for various image contents. This motivates work on DCT schemes adaptive to the image contents so that a better tradeoff between bit rate and image quality can be achieved. In this paper a DCT algorithm with adaptive thresholding and quantization is combined with variable block size segmentation to further improve the coding performance. A new segmentation criterion is proposed. Some simulation results are given to illustrate the superiority of this adaptive DCT algorithm with segmented blocks. It is also shown that this algorithm poses itself as a promising compression method to deal with the composite images consisting of text/graphics and natural scenes.
Nephroprotektion durch Antihypertensiva (1999)

Trotz enormer technischer Fortschritte und optimierter Therapiemöglichkeiten stellt die chronisch progrediente Niereninsuffizienz ein zunehmendes globales, sozioökonomisches und medizinisches Problem dar, da Erkrankungshäufigkeit und Sterblichkeitsrate stetig ansteigen. Die arterielle Hypertonie ist nach dem Diabetes mellitus die zweithäufigste Ursache für ein chronisches Nierenversagen. In Anbetracht der Tatsache, daß beide Erkrankungen effektiv behandelt werden können, stellt sich die Frage nach einer Verbesserung und intensiveren Ausschöpfung der zur Verfügung stehenden Behandlungsstrategien. In diesem Zusammenhang konnte gezeigt werden, daß eine medikamentöse Blutdrucksenkung unterhalb des klassischen Zielwerts von 140/90 mmHg zu einer Verlangsamung der Progression des Nierenfunktionsverlusts beiträgt. Dieser Zielblutdruck kann primär durch alle derzeit verfügbaren Hochdruckmedikamente erreicht werden. Der wesentliche Unterschied zwischen den Vertretern der verschiedenen Substanzklassen begründet sich in den von der Blutdrucksenkung unabhängigen nephroprotektiven Eigenschaften. Insbesondere die Klasse der ACE-Hemmer und Angiotensin II-AT1-Rezeptorantagonisten führen blutdruckunabhängig zu einer günstigen Beeinflussung der renalen Hämodynamik und der Nierenfunktion, während Diuretika und ß-Blocker in äquipotent blutdrucksenkender Dosis die Nierenfunktion eher verschlechtem. Die Datenlage zur nephroprotektiven Potenz der Kalziumantagonisten ist kontrovers, insbesondere wenn man nach harten Endpunkten sucht. Für die ACE-Hemmer dagegen gibt es mehrere prospektive Studien, in denen eine über die Blutdrucksenkung hinausgehende Verhinderung des Nierentodes dokumentiert wurde. Inwieweit sich Angiotensin II-AT1-Rezeptorantagonisten in ihrer Langzeitwirkung auf die Nierenfunktion von der Klasse der ACE-Hemmer unterscheiden, wird sich erst im Rahmen placebokontrollierter, prospektiver Langzeitstudien erweisen.
Changes in Autonomic Activity Preceding Onset of Nonsustained Ventricular Tachycardia (1996)

Changes in the pattern of HRV prior to the onset of episodes of NSVT suggest that changes in autonomic activity may commonly play a role in the triggering of spontaneous episodes of NSVT in susceptible patients. The measured changes suggest a reduction in parasympathetic activity, perhaps in conjunction with an increase in sympathetic activity, may trigger NSVT.
Mild traumatic brain injury (2012)

Traumatic Brain Injury (TBI) is among the most frequent neurological disorders. Of all TBIs 90% are considered mild with an annual incidence of 100–300/100.000. Intracranial complications of Mild Traumatic Brain Injury (MTBI) are infrequent (10%), requiring neurosurgical intervention in a minority of cases (1%), but potentially life-threatening (case fatality rate 0,1%). Hence, a true health management problem exists because of the need to exclude the small chance of a life threatening complication in large numbers of individual patients. The 2002 EFNS guidelines used a best evidence approach based on the literature until 2001 to guide initial management with respect to indications for CT, hospital admission, observation and follow up of MTBI patients. This updated EFNS guideline version for initial management inMTBI proposes a more selectively strategy for CT when major (dangerous mechanism, GCS<15, 2 points deterioration on the GCS, clinical signs of (basal) skull fracture, vomiting, anticoagulation therapy, post traumatic seizure) or minor (age, loss of consciousness, persistent anterograde amnesia, focal deficit, skull contusion, deterioration on the GCS) risk factors are present based on published decision rules with a high level of evidence. In addition clinical decision rules for CT now exist for children as well. Since 2001 recommendations, although with a lower level of evidence, have been published for clinical in hospital observation to prevent and treat other potential threads to the patient including behavioral disturbances (amnesia, confusion and agitation) and infection.
Autonomous Collision Avoidance for a Teleoperated UAV Based on a Super-Ellipsoidal Potential Function (2016)

This thesis presents the design of a super-ellipsoidal potential function (SEPF) that can be used, in a static and dynamic environment, for autonomous collision avoidance of an unmanned aerial vehicle (UAV) in a 3-dimensional space. In the design of the SEPF, we have the full control over the shape and size of the potential function. In our proposed approach, a teleoperated UAV can not only autonomously avoid collision with surrounding objects but also track the operator' control input as closely as possible. As a result, an operator can always be in control of the UAV for his/her high-level guidance and navigation task without worrying too much about the UAV collision avoidance while it is being teleoperated. The effectiveness of the proposed approach is demonstrated through a human-in-the-loop simulation using virtual robot experimentation platform (v-rep) and Matlab programs and experimentation using a physical quadrotor UAV in a laboratory environment.
Astrology, Alchemy and Retro-Organization Theory: An Astro-Genealogical Critique of the Myers-Briggs Type Indicator® (2004)

The influence of astrology and alchemy on organizational conduct has not hitherto attracted much serious social scientific attention. Retro-organizational theory licenses paying closer attention to topics that are systematically occluded by modern knowledge regimes and is invoked in this article to examine the manner in which premodern cosmologies underpin certain contemporary organizational practices. The Myers-Briggs Type Indicator ® (MBTI) is presented as a particularly conspicuous example of how the modern may be suffused by the premodern. An astro-genealogical account of the development of the MBTI ® is offered, tracing its Jungian origins and exposing structural debts to Renaissance thinking and earlier forms of symbolism. The article concludes with a consideration of Latour’s claim that ‘we have never been modern’ and suggests ways in which his hybridization critique of modernity connects with astrological and alchemical cosmology.
GaAs-Ga$sub 1$/sub hyphen//sub xAl/sub x/As double-heterostructure injection lasers with distributed Bragg reflectors (1976)

Laser oscillation in injection-pumped GaAs-Ga/sub 1-x/Al/sub x/As double- heterostructure distributed Bragg reflector (DBR) lasers is reported. Current threshold density as low as 890 A/cm$sup 2$ in pulsed operation has been obtained at 183$sup 0$K. In this laser diode, the corrugations are placed outside the active part of the laser in the form of an end pair of parallel Bragg reflectors. The observed characteristics of the DBR lasers are found to agree well with the theory. (AIP)
Learning Topics using Semantic Locality (2018)

The topic modeling discovers the latent topic probability of the given text documents. To generate the more meaningful topic that better represents the given document, we proposed a new feature extraction technique which can be used in the data preprocessing stage. The method consists of three steps. First, it generates the word/word-pair from every single document. Second, it applies a two-way TF-IDF algorithm to word/word-pair for semantic filtering. Third, it uses the K-means algorithm to merge the word pairs that have the similar semantic meaning. Experiments are carried out on the Open Movie Database (OMDb), Reuters Dataset and 20NewsGroup Dataset. The mean Average Precision score is used as the evaluation metric. Comparing our results with other state-of-the-art topic models, such as Latent Dirichlet allocation and traditional Restricted Boltzmann Machines. Our proposed data preprocessing can improve the generated topic accuracy by up to 12.99\%.
Design, Synthesis, and Evaluation of Phospholipid Analogs as Inhibitors of the Bacterial Phospholipase C from Bacillus cereus (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDesign, Synthesis, and Evaluation of Phospholipid Analogs as Inhibitors of the Bacterial Phospholipase C from Bacillus cereusStephen F. Martin, Yue-Ling Wong, and Allan S. WagmanCite this: J. Org. Chem. 1994, 59, 17, 4821–4831Publication Date (Print):August 1, 1994Publication History Published online1 May 2002Published inissue 1 August 1994https://pubs.acs.org/doi/10.1021/jo00096a024https://doi.org/10.1021/jo00096a024research-articleACS PublicationsRequest reuse permissionsArticle Views536Altmetric-Citations53LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
High-performance thin-film silicon-on-insulator CMOS transistors in porous anodized silicon (1989)

Ultrathin-film silicon-on-insulator (SOI) CMOS transistors, produced in silicon islands 100 nm thick, formed by oxidation of porous anodized silicon, are described. Both n-channel and p-channel mobilities are similar to equivalent bulk values. Subthreshold slopes are less than 80 mV/decade and junction leakages are approximately 0.1 pA/ mu m. No kink is seen in the output characteristics of the n-channel transistors as the silicon film is fully depleted. A ring-oscillator gate delay of 161 ps has been achieved, at a power dissipation of 270 mu W/stage, for 1.5- mu m gate length.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>