gebhart/patrepeval huggingface dataset:
Space-time acoustic scintillation analysis: A new technique for probing ocean flows (1986)

We present a new approach to the measurement of ocean flows. The technique exploits the coherence of the fine structure in the ocean under the influence of advection. Sound passing through this fine structure is modulated in space and time, so that the evolution and motion of the resulting pattern at a distant receiving plane contains information about the intervening flow field. The details of the fine-scale structure itself may also be recovered, to an extent determined by the complexity of the transmitter and receiver array. Two special cases of oceanographic interest are considered. First, a fully developed turbulent flow, such as that encountered in tidal channels, for which the scale of fine structure contributing to the scintillation field lies within the inertial subrange, and second, the internal wave field more generally applicable to the open ocean. We describe an experimental test of the concept. Sound traveling across a 0.66-km path in Cordova Channel, British Columbia, Canada, is detected by two closely spaced receivers. The flow speed is derived using three separate estimators and the results compared with current measurements obtained from a moored current meter. Agreement between the two types of measurement is excellent.
Dam safety legislation update (1997)

Progress in developing dam safety legislation in New Zealand through an amendment to the Building Act is described. Key decisions to date and key features of a discussion paper on dam safety which was issued to interested parties for comment are outlined. Policy issues arising out of the responses to the discussion paper are then discussed.
Bone cancer pain: Causes, consequences, and therapeutic opportunities (2013)

Common cancers, including cancers of the breast, lung, and prostate, frequently metastasize to multiple bones where they can cause significant and life-altering pain. Similar to cancer itself, the factors that drive bone cancer pain evolve and change with disease progression. Once cancer cells have metastasized to bone, both the cancer cells and their associated stromal cells generate pain by releasing algogenic substances including protons, bradykinin, endothelins, prostaglandins, proteases, and tyrosine kinase activators. The release of these factors by cancer/stromal cells can induce sensitization and activation of nerve fibers that innervate the bone. Additionally, these factors can drive a remarkable increase in the number, size, and activity of bone-destroying osteoclasts, which can ultimately result in fracture of the tumor-bearing bone. Tumor growth in bone can also generate a neuropathic pain by directly injuring nerve fibers as well as inducing an active and highly pathological sprouting of both sensory and sympathetic nerve fibers that normally innervate the bone. This structural reorganization of sensory and sympathetic nerve fibers in the bone, combined with the cellular and neurochemical reorganization that occurs in the spinal cord and brain, appears to contribute to the peripheral and central sensitization that is common in advanced bone cancer pain. These mechanistic insights have begun to lead to advances in both how we understand and treat bone cancer pain.
Immunoblot analysis of a 10 kDa antigen in cyst fluid of<i>Taenia solium</i>metacestodes (1998)

The diagnostic value of a 10 kDa subunit of 150 kDa protein in cyst fluid (CF) of Taenia solium metacestodes was evaluated. Immunoblot analysis revealed that most sera from patients with neurocysticercosis recognized the 10 kDa subunit strongly (209/217 cases, 84.6%), while a few sera from individuals with other parasitic diseases including alveolar echinococcosis (AE, 2/20, 10%) and cystic echinococcosis (CE, 2/25, 8%) showed faint reactions. Sera of cases with other parasitic diseases, especially AE and CE, exhibited cross reactions against other bands in CF. Both differential immunoblot and immunoprecipitation analyses showed that the 10 kDa subunit was the most specific to cysticercosis and highly antigenic, whereas other components at 20-40, 64, 95 and 106 kDa in CF were cross-reactive. IgG subclass ELISA and immunoblot demonstrated that both IgG4 and IgG1 reactions were predominant in neurocysticercosis and recognized the 10 kDa.
Optical Kerr effect in long fibers (1981)

Optical Kerr modulation of >100% is demonstrated in long birefringent optical fibers using low laser powers of ~1 W. We have experimentally investigated the effects of group-velocity dispersion, thermal stability of polarization, and fiber birefringence. Use of fiber Kerr modulation as a fast optical shutter is studied, and it is concluded that resolution times shorter than 1 psec are possible in principle.
Handbook of molecular sieves (1992)

Natural zeolites Synthetic zeolites Synthesis of zeolite materials Zeolite characteristics Crystalline molecular sieve materials Synthesis of molecular sieve materials Molecular sieve characteristics Molecular sieve technology.
Highly Efficient and Versatile Plasmid-Based Gene Editing in Primary T Cells (2018)

Adoptive cell transfer is an important approach for basic research and emerges as an effective treatment for various diseases, including infections and blood cancers. Direct genetic manipulation of primary immune cells opens up unprecedented research opportunities and could be applied to enhance cellular therapeutic products. In this article, we report highly efficient genome engineering in primary murine T cells using a plasmid-based RNA-guided CRISPR system. We developed a straightforward approach to ablate genes in up to 90% of cells and to introduce precisely targeted single nucleotide polymorphisms in up to 25% of the transfected primary T cells. We used gene editing-mediated allele switching to quantify homology-directed repair, systematically optimize experimental parameters, and map a native B cell epitope in primary T cells. Allele switching of a surrogate cell surface marker can be used to enrich cells, with successful simultaneous editing of a second gene of interest. Finally, we applied the approach to correct two disease-causing mutations in the <i>Foxp3</i> gene. Repairing the cause of the scurfy syndrome, a 2-bp insertion in <i>Foxp3,</i> and repairing the clinically relevant Foxp3<sup>K276X</sup> mutation restored Foxp3 expression in primary T cells.
Galvanostatic Transients in Lutetium Diphthalocyanine Films (1980)

The anodic oxidation of lutetium diphthalocyanine films on tin oxide in was investigated by a galvanostatic transient technique. The reaction was monitored by simultaneous measurement of the optical transmission. At current densities of 0.3–6 mA/cm2, the kinetics was controlled by an ionic space charge in the red oxidation product. A dielectric constant of 10 was estimated for this material, using the solid‐state mobility of the chloride ion determined in a previous moving‐boundary study.
Comparison of two doses of cabazitaxel plus prednisone in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC) previously treated with a docetaxel (D)-containing regimen. (2012)

TPS4692^ Background: The phase III TROPIC study (NCT00417079) reported a significant improvement in overall survival (OS) for cabazitaxel (Cbz) + prednisone (P;CbzP) (25 mg/m 2 IV Q3W/10 mg PO QD) vs mitoxantrone (M) + P (MP) (median OS 15.1 vs 12.7 mos; HR 0.70; P < 0.0001) in pts with mCRPC (also known as hormone-refractory prostate cancer) previously treated with a D-containing regimen. CbzP is approved by the FDA, EMA and other health authorities for the treatment of pts with mCRPC that has progressed after a D-containing regimen. Cbz toxicity is consistent with other taxanes; compared with M, more hematologic toxicities are reported (primarily Grade 3–4 neutropenia). Phase I/II studies identified 20 and 25 mg/m 2 as recommended doses; 25 mg/m 2 was selected for the phase III TROPIC study. As pooled data show Grade 3–4 neutropenia incidence is lower with Cbz < 25 mg/m 2 (61%) vs ≥ 25 mg/m 2 (74%), it is of interest to assess if reducing the Cbz approved dose in mCRPC lessens hematologic toxicity and is non-inferior in terms of efficacy. Methods: PROSELICA (NCT01308580) is a randomized, open-label, multinational, phase III study comparing 20 mg/m 2 and 25 mg/m 2 Cbz for efficacy and tolerability. Pts with a life expectancy > 6 mos, ECOG PS ≤ 2, histologically/cytologically confirmed metastatic prostate adenocarcinoma resistant to hormone therapy and previously treated with a D-containing regimen are eligible. Pts are randomized 1:1 to receive Cbz 20 mg/m² or 25 mg/m² IV Q3W + P 10 mg PO QD, treated until disease progression, unacceptable toxicity or withdrawal of consent (max 10 cycles), and stratified according to ECOG PS, measurable disease (yes/no) and region. The primary endpoint is OS (non-inferiority design). Secondary endpoints include safety, progression-free survival (PCWG2 criteria), PSA and pain progression and response, tumor response in pts with measurable disease and health-related quality of life. Cbz PK and pharmacogenomics will be assessed in pt subgroups. Planned enrollment is 1,200 pts. Study start was in May 2011; as of Jan 2012, 270 pts had been enrolled. The first DMC meeting recommended continuing the study without change.
CVD-diamond external cavity Raman laser at 573 nm (2008)

Recent progress in diamond growth via chemical vapor deposition (CVD) has enabled the manufacture of single crystal samples of sufficient size and quality for realizing Raman laser devices. Here we report an external cavity CVD-diamond Raman laser pumped by a Q-switched 532 nm laser. In the investigated configuration, the dominant output coupling was by reflection loss at the diamond's uncoated Brewster angle facets caused by the crystal's inherent birefringence. Output pulses of wavelength 573 nm with a combined energy of 0.3 mJ were obtained with a slope efficiency of conversion of up to 22%.
40 Hz invisible spectral flicker and its potential use in Alzheimer's light therapy treatment (2020)

Alzheimer’s disease (AD) not only takes an emotional toll on the individual with the disease, their families, relatives, and caretakers, it also has immense socioeconomic consequences on the health care system and society. Moreover, the socioeconomic consequences are expected to increase significantly, thus reducing the social and economic cost of AD is of high importance. Recently, exposure to 40 Hz stroboscopic light therapy, for one hour a day, resulted in slowing the progression of AD in mice and has a considerable potential for treatment in humans. However, exposure to such stroboscopic light carries its own consequences being that it is difficult to implement in a patient’s daily routine, irksome to use, and can cause visual discomfort which may result in a lack of patient adherence. Here, we demonstrate a novel technology based on controlling multiple single-color LEDs to produce white light where its spectral composition alternates at a given modulation frequency without visible flicker. We coin this technique as Invisible Spectral Flicker (ISF). We present 40 Hz invisible spectral flicker light as a potential alternative in reducing discomfort compared to 40 Hz stroboscopic light, whilst still entraining oscillations in various areas of the brain. Furthermore, we demonstrate a distinct way to generate a 40 Hz metameric light source with the presented color mixing scheme, and validate that the CIE 1931 (x, y) coordinates match for two different spectral power distributions. Finally, we illustrate the light characteristics of seven 40 Hz color fusion light sources and two 40 Hz stroboscopic light sources. The technology presented here will lead to new, and hopefully improved, designs of light therapy systems for the treatment of Alzheimer’s and dementia.
Postexposure Prophylaxis against Anthrax: Evaluation of Various Treatment Regimens in Intranasally Infected Guinea Pigs (2002)

The efficiency of postexposure prophylaxis against Bacillus anthracis infection was tested in guinea pigs infected intranasally with either Vollum or strain ATCC 6605 spores (75 times the 50% lethal dose [LD(50)] and 87 times LD(50,) respectively). Starting 24 h postinfection, animals were treated three times per day for 14 days with ciprofloxacin, tetracycline, erythromycin, cefazolin, and trimethoprim-sulfamethoxazole (TMP-SMX). Administration of cefazolin and TMP-SMX failed to protect the animals, while ciprofloxacin, tetracycline, and erythromycin prevented death. Upon cessation of treatment all erythromycin-treated animals died; of the tetracycline-treated animals, two of eight infected with Vollum and one of nine infected with ATCC 6605 survived; and of the ciprofloxacin group injected with either 10 or 20 mg/kg of body weight, five of nine and five of five animals, respectively, survived. To test the added value of extending the treatment period, Vollum-infected (46 times the LD(50)) animals were treated for 30 days with ciprofloxacin or tetracycline, resulting in protection of eight of nine and nine of nine animals, respectively. Once treatment was discontinued, only four of eight and five of nine animals, respectively, survived. Following rechallenge (intramuscularly) of the survivors with 30 times the LD(50) of Vollum spores, all ciprofloxacin-treated animals were protected while none of the tetracycline-treated animals survived. In an attempt to confer protective immunity lasting beyond the termination of antibiotic administration, Vollum-infected animals were immunized with a protective antigen (PA)-based vaccine concurrently with treatment with either ciprofloxacin or tetracycline. The combined treatment protected eight of eight and nine of nine animals. Following cessation of antibiotic administration seven of eight and eight of eight animals survived, of which six of seven and eight of eight resisted rechallenge. These results indicate that a combined treatment of antibiotics together with a PA-based vaccine could provide long-term protection to prevent reoccurrence of anthrax disease.
Autonomous intelligent cruise control (2002)

Autonomous intelligent cruise control (AICC) is a vehicle-installed system which aids the driver both to keep the desired cruise speed and also to adapt the velocity in order to keep a safe distance to vehicles driven ahead of the host car. It can be operated in either informative or automatic mode: in informative mode the driver receives information whether the distance is safe or too close; in automatic mode the velocity is controlled automatically. The design of the AICC and its control algorithm are discussed. Simulations of varying traffic situations, with the AICC in automatic mode, show that the system handles these situations properly. The system is intended to be extended with road side communication in order to being able to keep the speed limits and pass traffic lights without stopping.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Mechanical Behavior and Fracture Toughness of Poly(<scp>L</scp>‐lactic acid)‐Natural Fiber Composites Modified with Hyperbranched Polymers (2004)

Abstract Summary: The use of hyperbranched polymers (HBP) with hydroxy functionality as modifiers for poly( L ‐lactic acid) (PLLA)‐flax fiber composites is presented. HBP concentrations were varied from 0 to 50% v/v and the static and dynamic tensile properties were investigated along with interlaminar fracture toughness. Upon addition of HBP, the tensile modulus and dynamic storage modulus ( E ′) both diminished, although a greater decline was noticed in the static modulus. The elongation of the composites with HBP showed a pronounced increase as large as 314% at 50% v/v HBP. The loss factor (tan δ ) indicated a lowering of the glass transition temperature ( T g ) due to a change in crystal morphology from large, mixed perfection spherulites to finer, smaller spherulites. The change in T g could have also resulted from some of the HBP being miscible in the amorphous phase, which caused a plasticizing effect of the PLLA. The interlaminar fracture toughness measured as the critical strain energy release rate ( G IC ) was significantly influenced by HBP. At 10% v/v HBP, G IC was at least double that of the unmodified composite and a rise as great as 250% was achieved with 50% v/v. The main factor contributing to high fracture toughness in this study was better wetting of the fibers by the matrix when the HBP was present. With improved ductility of the matrix, it caused ductile tearing along the fiber‐matrix interface during crack propagation. ESEM photograph of propagation region of the interlaminar fracture toughness specimens with 30% v/v of HBP. image ESEM photograph of propagation region of the interlaminar fracture toughness specimens with 30% v/v of HBP.
Chemical crosslinking of urokinase to pulmonary surfactant protein B for targeting alveolar fibrin (2003)

Intraalveolar fibrin formation is a consistent finding in acute inflammatory and chronic interstitial lung disease. Polymerization of fibrin in the presence of pulmonary surfactant results in far-reaching incorporation of the hydrophobic surfactant compounds into the growing fibrin matrix, with loss of surface activity, altered fibrin structure and reduced susceptibility of the clot to fibrinolysis. For specific targeting of such alveolar fibrin, we designed a hybrid molecule consisting of the catalytic domain of urokinase (B-chain) and the hydrophobic surfactant protein B (SP-B), termed SPUC. The urokinase B-chain, obtained by limited reduction of human two-chain-urokinase (u-PA) and subsequent affinity purification, was chemically coupled to SP-B in a semi-organic solvent system using a hetero-bifunctional crosslinker. Purification of the chimeric proteins included reversed phase and cation exchange chromatography. SDS-PAGE and Western Blotting with immunostaining were employed for biochemical characterization of the conjugate. Chromogenic substrate assays, (125)I-based fibrin plate assays, active site titration and surface tension measurements (pulsating bubble surfactometer) were performed to analyze the specific fibrinolytic activity of the conjugate and its surface activity. SPUC was found i) to be assembled stoichiometrically in a 1: 1 fashion (SP-B: u-PA), ii) to fully retain the biophysical activity as compared to native SP-B and iii) to also retain the fibrinolytic activity. SPUC was 2-3 fold more effective in lysis of surfactant containing clots and 5-fold more resistant against plasminogen activator 1 (PAI-1) as compared to the native u-PA. We conclude that urokinase and SP-B can be chemically crosslinked, thereby yielding a fibrinolytic enzyme suitable for targeting alveolar fibrin.
The acoustic echo cancelation using blind source separation to reduce double-talk interference (2014)

An acoustic echo canceler (AEC) is often employed to remove the acoustic echoes generated in hands-free communication systems. The AEC cancels the acoustic echoes by approximating the echo-path with the use of an adaptive filter and subtracting the pseudo echoes generated by the filter from the observed signal. The conventional adaptive algorithm for updating the filter, however, fails in estimation of the echo-path during double-talk when both the acoustic echo and the near-end speech are observed. Recently it has been shown that the blind source separation (BSS) can be employed to perform the echo cancelation during the double-talk; however, the convergence speed is slower than that of the conventional method. In this paper, a system is proposed that combines the conventional AEC and BSS; essentially, BSS is employed as a preprocessor for the adaptive filter performing the echo cancelation. Simulation results show that the proposed system is effective for the echo-path estimation during the double-talk as well as during variation in the echo path.
FT-IR spectroscopic imaging microscopy using an MCT focal-plane array detector (1998)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation C. Marcott, R. C. Reeder; FT-IR spectroscopic imaging microscopy using an MCT focal-plane array detector. AIP Conf. Proc. 1 June 1998; 430 (1): 377–378. https://doi.org/10.1063/1.55758 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
SIP network discovery by using SIP message probing (2008)

Currently more and more SIP based networks have been deployed in enterprises and communication carriers’ domain to provide NGN services. With the widely adoption of SIP, information discovery in SIP network, which is the first step of SIP management, becomes a key challenge to operators and service providers. To address the problem, this paper presents an automated SIP network discovery approach based on SIP message probing. With our approach, minimal number of SIP request messages will be sent out to probe SIP entities and then targeted information could be obtained by wrapping and parsing the received responses. Experiment results show that the approach can effectively obtain SIP information for management while it costs limited probing messages.
Rational Design of ZnFe<sub>2</sub>O<sub>4</sub>/In<sub>2</sub>O<sub>3</sub> Nanoheterostructures: Efficient Photocatalyst for Gaseous 1,2-Dichlorobenzene Degradation and Mechanistic Insight (2016)

Novel ZnFe2O4/In2O3 hybrid nanoheterostructures with enhanced visible-light catalytic performance were fabricated by assembling ZnFe2O4 nanoparticles on the surface of monodispersed In2O3 nanospheres, and their photocatalytic performances were evaluated via the degradation of gaseous 1,2-dichlorobenzene (o-DCB). The catalytic activity of the resulting heterostructures for degradation of o-DCB was higher than that of either pure In2O3 or ZnFe2O4. The enhanced activity was mainly ascribed to the enhanced visible-light harvesting ability, efficient spatial separation, and prolonged lifetimes of photogenerated charges. Meanwhile, the main reaction intermediates including o-benzoquinone type species, phenolate species, formates, acetates, and maleates were verified with in situ FTIR spectroscopy. Additionally, a tentative catalytic reaction mechanism and the generation pathway of •OH over the ZnFe2O4/In2O3 nanoheterostructures were postulated. The present work provides some significative information for the eradication of harmful chlorinated volatile organic compounds and is expected to benefit the development of In2O3-based hybrid heterostructures.