gebhart/patrepeval huggingface dataset:
Protein domain mimetics as in vivo modulators of hypoxia-inducible factor signaling (2013)

Selective blockade of gene expression by designed small molecules is a fundamental challenge at the interface of chemistry, biology, and medicine. Transcription factors have been among the most elusive targets in genetics and drug discovery, but the fields of chemical biology and genetics have evolved to a point where this task can be addressed. Herein we report the design, synthesis, and in vivo efficacy evaluation of a protein domain mimetic targeting the interaction of the p300/CBP coactivator with the transcription factor hypoxia-inducible factor-1α. Our results indicate that disrupting this interaction results in a rapid down-regulation of hypoxia-inducible genes critical for cancer progression. The observed effects were compound-specific and dose-dependent. Gene expression profiling with oligonucleotide microarrays revealed effective inhibition of hypoxia-inducible genes with relatively minimal perturbation of nontargeted signaling pathways. We observed remarkable efficacy of the compound HBS 1 in suppressing tumor growth in the fully established murine xenograft models of renal cell carcinoma of the clear cell type. Our results suggest that rationally designed synthetic mimics of protein subdomains that target the transcription factor-coactivator interfaces represent a unique approach for in vivo modulation of oncogenic signaling and arresting tumor growth.
Comparison of Polarizers for Neutron Radiography (2010)

Imaging with polarized neutrons is a new method to measure the spatially resolved magnetisation. It is based on the interaction of a polarized neutron beam with magnetic fields. In this paper we present an overview of different polarizing techniques and their application for neutron imaging. The performance of various setups is discussed. It is demonstrated that radiography with polarized neutrons may evolve into an important technique for determining the homogeneity of ferromagnetic samples.
Immunosuppression with cyclosporin A alters the thymic microenvironment. (1989)

The effect of cyclosporin A (CyA) immunosuppression on the murine thymic microenvironment and T lymphocyte development has been analysed using monoclonal antibodies to epithelial and lymphocyte subpopulations, macrophages and major histocompatibility complex (MHC) class II antigens in immunohistochemistry and flow cytometry. The major microenvironmental target for CyA-induced damage was the thymic medulla, where a reduction in all epithelial cell subsets, dendritic cells and macrophages was observed. In contrast, the thymic cortex appeared essentially normal. CyA had no detectable effect on the intensity of microenvironmental expression of MHC class II molecules in either cortex or medulla, although the number of MHC class II positive medullary cells was reduced after CyA treatment. CyA also had a differential effect on the thymic lymphocyte populations where there was little change in the Thy-1 bright, CD5 dull, CD4+, CD8+ cortical thymocytes but a depletion of the Thy-1 dull, CD5 bright, CD4 or CD8 single-positive medullary cells. This lymphocyte loss may be due partly to increased migration from thymus to spleen and other peripheral lymphoid organs, and partly to a block in the differentiation stage from cortical to medullary lymphocyte. The thymic microenvironment and lymphocyte subpopulations recover rapidly after cessation of CyA treatment, although there may be longer term functional defects resulting from the CyA-induced injury.
Iron—Thioglycolate Complexes (1953)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIron—Thioglycolate ComplexesD. L. Leussing and I. M. KolthoffCite this: J. Am. Chem. Soc. 1953, 75, 16, 3904–3911Publication Date (Print):August 1, 1953Publication History Published online1 May 2002Published inissue 1 August 1953https://doi.org/10.1021/ja01112a009Request reuse permissionsArticle Views349Altmetric-Citations37LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (962 KB) Get e-Alertsclose Get e-Alerts
Atom Transfer Radical Polymerization of Menthyl Acrylate (2007)

Atom transfer radical polymerization (ATRP) of menthyl acrylate (MnA) was performed with different catalytic systems. ATRP of MnA proceeds in a controlled/living manner as evidenced by narrow polymer polydispersity (<1.20), but with a very slow polymerization rate using 1-phenylethyl bromide (1-PEBr) or ethyl 2-bromopropionate (2-EBP) as initiators (monomer/initiator = 100/1) and N,N,N‘,N‘,N‘ ‘-pentamethyldiethylenetriamine (PMDETA) as ligand. Only 5.7% and 14.8% monomer conversion were obtained within 4 h using 1-PEBr and 2-EBP, respectively. In contrast, replacing the PMDETA ligand with 1,4,8,11-tetramethyl-1,4,8,11-tetraazacyclotetradecane (Me4cyclam) promotes a very fast but uncontrolled polymerization (97.1% conversion in 1 h with a polydispersity as broad as 1.70). However, a controlled/living polymerization system of MnA (with a relatively fast polymerization rate, 78.4% conversion in 1/2 h; Mn = 14 000 g/mol; Mw/Mn = 1.11) was achieved by using tris[2-(dimethylamino)ethyl]amine (Me6TREN) as ligand. The controlled/living feature of this system allowed the chain extension polymerization of methyl acrylate (MA) to synthesize the block copolymer, poly(menthyl acrylate)-block-poly(methyl acrylate) [PMnA-b-PMA]. The thermal stability of PMnA was investigated by thermogravimetric analysis (TGA) and gas chromotography/mass spectrometry (GC/MS). The pyrolysis of PMnA (with the release of menthenes) provides an alternative route to synthesize poly(acrylic acid) with controlled structures from PMnA (prepared by ATRP of MnA).
Synthetic porphyrins/metalloporphyrins which mimic states in catalytic cycle of cytochrome P-450 and peroxidases (1993)

Abstract
Regulation of endobiotics glucuronidation by ligand-activated transcription factors: physiological function and therapeutic potential (2009)

Recent progresses in molecular pharmacology approaches have allowed the identification and characterization of a series of nuclear receptors (NR) which efficiently control the level UDP-glucuronosyltransferase (UGT) genes expression. These regulatory processes ensure optimized UGT expression in response to specific endogenous and/or exogenous stimuli. Interestingly, numerous endogenous activators of these NRs are conjugated by the UGT enzymes they regulate. In such a case, the NR-dependent regulation of UGT genes corresponds to a feedforward/feedback mechanism by which a bioactive molecule controls its own concentrations. In the present review, we will discuss i) how bilirubin reduces its circulating levels by activating AhR in the liver; ii) how bile acids modulate their hepatic glucuronidation via PXR- and FXR-dependent processes in enterohepatic tissues; and iii) how androgens inhibit their cellular metabolism in prostate cancer cells through an AR-dependent mechanism. Subsequently, with further discussion of the same examples (bilirubin and bile acids), we will illustrate how NR-dependent regulation of UGT enzymes may contribute to the beneficial effects of pharmacological activators of nuclear receptors, such as CAR and PPARa.
Fundamentals of plasmonics (2014)

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Optical transmission in highly concentrated dispersions (1998)

The intensity temporal profiles of diffusive light propagation in highly concentrated (up to volume fraction ϕ∼0.55) dispersions measured by 100-fs laser pulses showed an increase in transport scattering mean free path above a critical concentration. This observation confirms the previous theoretical predictions of enhanced transmission at high particle concentrations due to correlated scattering. The correlation effects are accounted for by incorporating a hard sphere Percus–Yevick static structure factor into the prediction of transport mean free path.
Newscripts (1978)

RETURN TO ISSUEPREVNewsNEXTNewscriptsK. M. REESECite this: Chem. Eng. News 1978, 56, 28, 70Publication Date (Print):July 10, 1978Publication History Published online7 November 2010Published inissue 10 July 1978https://pubs.acs.org/doi/10.1021/cen-v056n028.p070https://doi.org/10.1021/cen-v056n028.p070newsACS PublicationsCopyright © 1978 American Chemical SocietyArticle Views6Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Determination of Synchronous Fluorescence Scan Parameters for Certain Petroleum Products (2000)

analytical purposes the SFS parameters that are needed to be optimized are I1A (A - \,) and synchronous fluorescence maximum. In the present work, conventional petroleum products available in Indian market lik e kerosene and petrol, and added lubri cant namely 2T oil have been studied with respect to th eir SFS parameters. For these multifluorophoric systems conven­ tional electronic absorption and fluorescence spectroscopy is of limited use. The effect of dilution (5 - 100 per cent, v/v in cyclohexane) on the SFS parameters has been exami ned. In these multifluorophoric systems, excitation energy tran s fer results in shifting of synchronous fluorescence maxima with increasi ng concentration of the petroleum product. The correlation o f thi s shift with concentration shows th e possibility of using it as an analyt ical method to quantify th e petroleum products in th e environment.
Evaluation of Glutaraldehyde and Povidone Iodine for Sterilization of Wide-Field Contact Vitrectomy Lenses (2001)

Two hours contact time with glutaraldehyde 2% or providone iodine 5% can sterilize vitrectomy contact lenses against common bacteria and fungi without affecting lens quality.
Effects of long term storage of semen in liquid nitrogen on the viability, motility and abnormality of frozen thawed Frisian Holstein bull spermatozoa (2015)

To evaluate effects of long term storage of semen in liquid nitrogen on the motility, concentration, viability, and abnormality of frozen-thawed. A total of four Friesian Holstein bulls were used for this study. One hundred forty semen straws with produced during period from 2008 to 2013 and stored in the liquid nitrogen at the AI center were used in the research. The sample straw was divided into six groups; each group consist 20 semen straws. For group one all straw semen was produced on the 2013 with storage in liquid nitrogen as long as one year, the group 2, 3, 4, 5, and 6 were produced on the 2012, 2011, 2010, 2009 and 2008 with storage in liquid nitrogen as long as 2, 3, 4, 5, and 6 year, respectively. The viability of thawed sperm was not significantly different decreased (P>0.05) between storage on the 1 year and storage on the 2 years. Whereas, the viability was significantly different (P<0.05) with storage on the 3, 4, 5 and 6 years. The motility of thawed sperm was not significantly different decreased (P>0.05) on the storage 1, 2 and 3 years. Whereas, the motility was significantly different (P<0.05) with storage on the 4, 5 and 6 years. The abnormality of thawed sperm was not significantly different increased (P>0.05) on the storage 1, 2 and 3 years. Whereas, the abnormality was significantly increased (P<0.05) with storage on the 4, 5 and 6 years. On the other hand the concentration of thawed sperm was not significantly different decreased (P>0.05) during storage in liquid nitrogen as long as six years. Based on the results in these experiments, it may be concluded that concentration sperm during one year storage in liquid nitrogen resulted in similar concentration storage as long as six years. However, the viability and motility sperm thawed storage in liquid nitrogen during six years was lower than storage on the 1 and 2 years.
SDA: Software-Defined Accelerator for general-purpose big data analysis system (2016)

Presents a collection of slides covering the following: software architecture; Big Data; data analysis; and SQL.
An engineering study of the film embossing process (1985)

Abstract A mathematical model of the dynamics and heat transfer of the film embossing process has been developed. The thermal analysis around the preheat roll is determined from an unsteady, two‐dimensional heat conduction equation along with appropriate boundary conditions by neglecting the curvature of the preheat roll and choosing a Lagrangian reference frame. The heat transfer occurring between the preheat roll and the embossing rolls is based on a one‐dimensional analysis, including both convective and radiative effects. The deformation occurring in the nip region is analyzed for two different situations. For the case where the surface features are small in comparison with the film thickness, a modified one‐dimennsional calendering analysis is given, accounting for the irregular geometry of the embossing roll surface. For the case where the polymer does not make complete contact with the surface of the engraved channel, the local deformation is determined by means of a simple one‐dimensional cavity filling model. The required pressure distribution is determined by means of a simple one‐dimensional cavity filling model, The required pressure distribution is determined by means of a conventional calendering analysis. The analysis for the case of a Newtonian and power‐law model is presented in detail. The model yields qualitatively correct results and is computationally simple.
Multifunctional Carbon Nanofibers with Conductive, Magnetic and Superhydrophobic Properties (2006)

Multifunctional carbon nanofibers (CNFs, see picture), fabricated by a simple electrospinning method, show not only outstanding conductive and magnetic but also superhydrophobic characteristics, which make these materials attractive for the application as corrosive protection and electromagnetic shielding coating. The conductive and magnetic properties of these materials are maintained by the superhydrophobic surfaces.
Interaction of cavitation bubbles with a free surface (2001)

The motion of single- and two-cavitation bubbles generated by laser beams directly beneath a free surface is studied experimentally, using high-speed photography, and theoretically using the highly accurate boundary integral method. Favorable comparisons of bubble shape history and centroid motion are observed while the numerical calculations provide information on the pressure field surrounding the bubbles. A range of responses, including the null impulse state, is obtained for the two bubbles depending on the bubble size ratio and the interbubble and bubble-free surface distances, although in all cases reported in this article, the bubble nearest the free surface yields a high-speed liquid jet directed away from the free surface. It is also found that when the free-surface–bubble interaction is strong, a fast free-surface spike is formed for both the single- and two-bubble cases.
On-line Chinese Character Recognition System for Overlapping Samples (2011)

We proposed a new process strategy for on-line handwriting Chinese Character recognition and applied it to overlapping samples. On one hand, those samples are evaluated on stroke level by support vector machine, on the other hand, we do character level evaluation basing on a character pair search model. Then a merging strategy was proposed to filter out correct segmentation positions. We test our strategy on samples from real context, verifying that our strategy performs better than traditional over-segmentation and merging method.
Comparative spontaneous Raman spectroscopy of crystals for Raman lasers (1999)

A comparison of the spectroscopic parameters of Raman-active vibronic modes in various crystalline materials with a view to the use of these crystals for stimulated Raman scattering (SRS) is presented. It includes data on the Raman frequency shift, linewidth, integral, and peak Raman scattering cross sections. For steady-state SRS the highest Raman gain coefficient has been proved to be in barium nitrate and sodium nitrate crystals; for transient SRS it is expected to be in lithium niobate and tungstate crystals. Barium tungstate and strontium tungstate are proposed as new highly efficient Raman materials for both SRS cases.
Electron beam lithography time dependent dose correction for reticle CD uniformity enhancement (2006)

This paper includes an empirical determination of the relative CD error as a function of in-vacuum post exposure delay (PED). The effects of local pattern density and the impact of reticle proximity effect correction on the in-vacuum PED CD bias error are also considered. Results of dose compensation to improve CD uniformity on both artifact and production reticles are reviewed. The results show that by applying an exposure time dependent dose correction, the CD bias dependency upon in-vacuum PED is effectively compensated. In addition, the results show that dose compensation is effective at correcting for the in-vacuum PED dependency of local pattern density proximity errors. Finally, the paper concludes with a brief discussion of the relationship between existing reticle CD correction techniques for errors including electron beam fogging, etch loading, stable reticle process spatial CD non-uniformities and the new time dependent dose correction.
Preparation and Presentation of Digital Maps in Raster Format (1980)

A set of algorithms has been developed at USGS (U.S. Geological Survey)–Flagstaff for displaying digital map data in raster format. The set includes: FILLIN, which assigns a specified attribute code to units of a map which have been outlined on a digitizer and converted to raster format; FILBND, which removes the outlines; ZIP, which adds patterns to the map units; and COLOR, which provides a simplified process for creating color separation plates for either photographic or lithographic reproduction.
Design of a maximum power tracking system for wind-energy-conversion applications (2006)

A wind-generator (WG) maximum-power-point-tracking (MPPT) system is presented, consisting of a high-efficiency buck-type dc/dc converter and a microcontroller-based control unit running the MPPT function. The advantages of the proposed MPPT method are that no knowledge of the WG optimal power characteristic or measurement of the wind speed is required and the WG operates at a variable speed. Thus, the system features higher reliability, lower complexity and cost, and less mechanical stress of the WG. Experimental results of the proposed system indicate near-optimal WG output power, increased by 11%-50% compared to a WG directly connected via a rectifier to the battery bank. Thus, better exploitation of the available wind energy is achieved, especially under low wind speeds.
Systematic generation of FPGA-based FFT implementations (2008)

In this paper, we propose a systemic approach for synthesizing field-programmable gate array (FPGA) implementations of fast Fourier transform (FFT) computations. Our approach considers both cost (in terms of FPGA resource requirements), and performance (in terms of throughput), and optimizes for both of these dimensions based on user-specified requirements. Our approach involves two orthogonal techniques-FFT inner loop unrolling and outer loop unrolling - to perform design space exploration in terms of cost and performance. By appropriately combining these two forms unrolling, we can achieve cost-optimized FFT implementations in terms of FPGA slices or block RAMs in FPGA, subject to the required throughput. We compared the results of our synthesis approach with a recently-introduced commercial FPGA intellectual property (IP) core - the FFT IP module in the Xilinx LogiCore Library, which provides different FFT implementations that are optimized for a limited set of performance levels. Our results demonstrate efficiency levels that are in some cases better than these commercial IP blocks. At the same time, our approach provides the advantages of being able to optimize implementations based on arbitrary, user-specified performance levels, and of being based on general formulations of FFT loop unrolling trade-offs, which can be retargeted to different kinds of FPGA devices.
Use of polycrystalline Nd:YAG rods to achieve pure radially or azimuthally polarized beams from high-average-power lasers (2010)

We report maintenance of perfect radial-polarization purity in high-power, cw pump chambers using strengthened, polycrystalline Nd:YAG laser rods. Although the cubic symmetry of single-crystal rods caused threefold symmetric birefringence due to shear stresses at the ends of the pumped zone, polycrystalline rods macroscopically behaved as isotropic material and enabled polarization preservation. Elimination of this source of depolarization prevents the major source of bifocusing aberrations in a chain of amplifiers.
Exhalation flow and pressure-controlled reservoir collection of exhaled nitric oxide for remote and delayed analysis (1998)

Flow and pressure controlled collection of exhaled NO into a reservoir with silica gel provides values identical to the direct measurement and may be used to monitor asthma at home and where analysers are not on site.
Surface wave communication system for on-chip and off-chip interconnects (2012)

Network-on-chip (NoC) is a communication paradigm that has emerged to tackle different on-chip challenges and satisfy different demands in terms of high performance and economical interconnect implementation. However, merely metal based interconnect pursuit offers limited scalability with the relentless technology scaling. To meet the scalability demand, this paper proposes a new hybrid interconnect fabric empowered by metal interconnect NoC and Zenneck surface Waves Interconnect (SWI) technology. Our initial results show a considerable power reduction (9 to 17%) and performance improvement (35%) of the proposed hybrid architecture compared to regular NoC. These results are achieved over relatively small hardware and area overhead (2.29% of die). This paper explores promising potentials of SWI for future System-on-Chip (SoC) global communication.