gebhart/patrepeval huggingface dataset:
Modeling and Analysis of Next Generation 9-1-1 Emergency Medical Dispatch Protocols (2013)

Emergency Medical Dispatch Protocols are guidelines that a 9-1-1 dispatcher uses to evaluate the nature of emergency, resources to send and the nature of help provided to the 9-1-1 caller. The current Dispatch Protocols are based on voice only call. But the Next Generation 9-1-1 (NG9-1-1) architecture will allow multimedia emergency calls. In this thesis I analyze and model the Emergency Medical Dispatch Protocols for NG9-1-1 architecture. I have identified various technical aspects to improve the NG9-1-1 Dispatch Protocols. The devices (smartphone) at the caller end have advanced to a point where they can be used to send and receive video, pictures and text. There are sensors embedded in them that can be used for initial diagnosis of the injured person. There is a need to improve the human computer (smartphone) interface to take advantage of technology so that callers can easily make use of various features available to them. The dispatchers at the 9-1-1 call center can make use of these new protocols to improve the quality and the response time. They will have capability of multiple media streams to interact with the caller and the first responders.The specific contributions in this thesis include developing applications that use smartphone sensors. The CPR application uses the smartphone to help administer effective CPR even if the person is not trained. The application makes the CPR process closed loop, i.e., the person who administers the CPR as well as the 9-1-1 operator receive feedback and prompt from the application about the correctness of the CPR. The breathing application analyzes the quality of breathing of the affected person and automatically sends the information to the 9-1-1 operator. In order to improve the Human Computer Interface at the caller and the operator end, I have analyzed Fitts law and extended it so that it can be used to improve the instructions given to a caller. In emergency situations, the caller may be physically or cognitively impaired. This may happen either because the caller is the injured person, or because the caller is a close relative or friend of the injured person. Using EEG waves, I have analyzed and developed a mathematical model of a person's cognitive impairment. Finally, I have developed a mathematical model of the response time of a 9-1-1 call and analyzed the factors that can be improved to reduce the response time. In this regard, another application, I have developed, allows the 9-1-1 operator to remotely control the media features of a caller's smartphone. This is needed in case the caller is unable to operate the multimedia features of the smartphone. For example, the caller may not know how to zoom in the smartphone camera.All these building blocks come together in the development of an efficient NG9-1-1 Emergency Medical Dispatch protocols. I have provided a sample of these protocols, using the existing Emergency Dispatch Protocols used in the state of New Jersey. The new protocols will have fewer questions and more visual prompts to evaluate the nature of the emergency.
Telomerase inhibitors and ‘T-oligo’ as cancer therapeutics: contrasting molecular mechanisms of cytotoxicity (2008)

Telomeres, the specialized structures that comprise the ends of chromosomes, form a closed structure, or t-loop, that is important in preventing genomic instability. Forced modulation of this structure, via overexpression of a dominant-negative form of telomere repeat binding factor 2, a protein critical for maintaining t-loop structure, for example, can result in the activation of DNA-damage responses, and ultimately cellular senescence or apoptosis. This response is also seen in normal somatic cells, where telomeres steadily decrease in length as cellular proliferation occurs owing to inefficient replication of terminal telomeric DNA. When telomere length becomes critically short, t-loop structure is compromised, and the cell undergoes senescence. Telomerase, the enzyme responsible for telomere length maintenance, is overexpressed in a majority of cancers. Its lack of expression in most normal somatic cells makes it an attractive target in designing cancer therapeutics. Compounds currently under development that seek to inhibit hTERT, the reverse transcriptase component of telomerase, include nucleoside analogs and the small molecule BIBR1532. Compounds inhibiting the RNA component of telomerase, hTERC, include peptide nucleic acids, 2-5A antisense oligonucleotides, and N3'-P5' thio-phosphoramidates. Recently, an oligonucleotide sharing sequence homology with terminal telomeric DNA, termed 'T-oligo', has shown cytotoxic effects in multiple cancers in culture and animal models. Independent of telomerase function, T-oligo is thought to mimic the DNA-damage response a cell normally experiences when the telomere t-loop structure becomes dysfunctional. In this review, the molecular mechanisms attributed to telomerase inhibitors and T-oligo, as well as their potential as cancer therapeutics, are discussed.
Approaches to African Literature (1960)

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Robust LS channel estimation with phase rotation for single frequency network in OFDM (2006)

A channel estimation technique has been proposed with the least square (LS) based on comb-type pilots for orthogonal frequency division multiplexing (OFDM). An interpolator should be used to obtain the channel information between adjacent pilots for a comb-type pattern. However, an interpolation method causes additional errors due to the interpolation properties of not detecting long delayed paths and generating fictitious paths, OFDM has its strength in realistic possibility of constructing the single frequency network (SFN). However, synchronization and channel estimation errors are revealed by multi-path fading with long delayed paths in SFN channels. We propose a robust channel estimator overcoming the adverse effects of long delayed signals in SFNs. A new channel estimator is proposed with the interpolated LS by applying phase shifted samples in the frequency-domain. In particular, the proposed channel estimator is more robust to the single frequency network (SFN) whenever the delay spread is less than the cyclic prefix length. For a Rayleigh channel, the proposed estimator has an almost 3 dB gain comparing to conventional estimator
Introduction To Numerical Analysis (1956)

Well-known, respected introduction, updated to integrate concepts and procedures associated with computers. Computation, approximation, interpolation, numerical differentiation and integration, smoothing of data, other topics in lucid presentation. Includes 150 additional problems in this edition. Bibliography.
Identification of a cell membrane protein that binds alveolar surfactant. (1991)

Alveolar surfactants are complex mixtures of proteins and phospholipids produced by type II alveolar cells and responsible for lowering pulmonary surface tension. The process by which surfactant is produced and exported and by which its production by pulmonary cells is regulated are not well understood. This study was designed to identify a cellular receptor for surfactant constituents. To do so, monoclonal anti-idiotypic antibodies directed against antibodies to porcine and rabbit surfactant proteins were prepared. These monoclonal anti-idiotypic antibodies bind both alveolar lining and bronchial epithelial cells in rabbit, porcine, and human lungs. Macrophages and other nonepithelial cells do not react with these antibodies. Western blot analysis indicates that both A2R and A2C recognize the same proteins in both pig and rabbit lungs: a 30-kd protein and additional proteins at 52 and 60 kd. Preincubating lung wash cells with A2C or A2R prevents binding of porcine or rabbit surfactant preparations, respectively, by these cells. Preincubating frozen sections of lung tissue with surfactant inhibits binding of A2R and A2C to the lung. Antibody directed to a cell membrane protein that recognizes alveolar surfactant may be useful in elucidating the structure and function of this receptor and in understanding the cellular physiology and pathophysiology of the surfactant system.
Comparison of regression pedotransfer functions and artificial neural networks for soil aggregate stability simulation (2010)

Abstract: Simulation of soil aggregate stability is a suitable method for saving time and cost spent for direct measurement. This research comprises regression pedotransfer functions (RegPTFs) and artificial neural networks (ANNs) for estimation of soil aggregate stability. 100 soil samples from forest and pasture&apos;s soils of Guilan Province in Iran were collected and geometric mean diameter (GMD), %silt (Si), %clay (Cl), %sand (Sa), bulk density (BD), equivalent carbonate calcium (CaCO 3), particle density (PD), soil mechanical resistance
β-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice (2010)

Cellular plasticity in adult organs is involved in both regeneration and carcinogenesis. WT mouse acinar cells rapidly regenerate following injury that mimics acute pancreatitis, a process characterized by transient reactivation of pathways involved in embryonic pancreatic development. In contrast, such injury promotes the development of pancreatic ductal adenocarcinoma (PDA) precursor lesions in mice expressing a constitutively active form of the GTPase, Kras, in the exocrine pancreas. The molecular environment that mediates acinar regeneration versus the development of PDA precursor lesions is poorly understood. Here, we used genetically engineered mice to demonstrate that mutant Kras promotes acinar-to-ductal metaplasia (ADM) and pancreatic cancer precursor lesion formation by blocking acinar regeneration following acute pancreatitis. Our results indicate that beta-catenin is required for efficient acinar regeneration. In addition, canonical beta-catenin signaling, a pathway known to regulate embryonic acinar development, is activated following acute pancreatitis. This regeneration-associated activation of beta-catenin signaling was not observed during the initiation of Kras-induced acinar-to-ductal reprogramming. Furthermore, stabilized beta-catenin signaling antagonized the ability of Kras to reprogram acini into PDA preneoplastic precursors. Therefore, these results suggest that beta-catenin signaling is a critical determinant of acinar plasticity and that it is inhibited during Kras-induced fate decisions that specify PDA precursors, highlighting the importance of temporal regulation of embryonic signaling pathways in the development of neoplastic cell fates.
Identification of a mitochondrial transporter for basic amino acids in <i>Arabidopsis thaliana</i> by functional reconstitution into liposomes and complementation in yeast (2003)

We describe the identification and functional characterization of two Arabidopsis mitochondrial basic amino acid carriers (BAC), AtmBAC1 and AtmBAC2, which are related to the yeast ornithine (Orn) carrier Ort1p, also known as Arg11p. The arg11 mutant requires arginine (Arg) supplementation because it fails to export sufficient ornithine from the mitochondrion to the cytosol where it is converted to arginine. AtmBAC1 and, to a lesser extent, AtmBAC2 partially replaced the function of Ort1p in yeast arg11. The more efficient putative carrier, AtmBAC1, was expressed in E. coli, purified, and reconstituted into phospholipid vesicles, where it transported the basic l-amino acids arginine, lysine, ornithine and histidine (in order of decreasing affinity). AtmBAC1 recognized l-histidine whereas both yeast Ort1p and the mammalian ortholog ORNT1p do not. Also different from ORNT1p, AtmBAC1 did not transport citrulline. AtmBAC1 appeared to be more stereospecific than the yeast and mammalian ornithine carriers, exhibiting greater preference for the l-forms of arginine, lysine and ornithine. By RT-PCR, both AtmBAC1 and AtmBAC2 transcripts were detected in stems, leaves, flowers, siliques, and seedlings. Expression of AtmBAC1 in seedlings is consistent with its involvement in Arg breakdown in early seedling development, i.e. delivery of Arg to mitochondrial arginase. The Km (0.19 mm) for Arg uptake by AtmBAC1 was close to the value we previously determined for the saturable component of Arg uptake into intact mitochondria from soybean seedling cotyledons.
Design for Manufacturing of Low-Voltage Three-Dimensional Capacitors (2010)

Given an existing manufacturing technology, the influence of the design parameters has been evaluated in order to improve the robustness of the 3-D capacitors. The objective is to select the capacitor patterns that provide a satisfying density with the required robustness with respect to the reliability indicators. The geometrical and manufacturing-related issues are both considered. The main manufacturing issues are the etching, deposition, and warpage of the wafer. The improvements have been observed experimentally for the robustness of the 3-D structures and the density of the capacitor which are increased for several proposed 3-D patterns. All capacitors tested in this paper are realized with PICS technology.
The Laryngeal Mask Airway Its Uses in Anesthesiology (1993)

The LMA is a useful airway device for most adult and pediatric patients. It is easy and atraumatic to insert, with minimal somatic and autonomic responses from the patient. It is a suitable alternative to the face mask and to tracheal intubation in a wide variety of clinical situations. In addition, the LMA facilitates blind and fiberoptic techniques of intubation, but its role in the emergency scenario has yet to be established. The preliminary experience gained with this device in Europe and Australasia suggests that it may also transform contemporary anesthetic practice in the United States.
Proteomic Analysis of Articular Cartilage Shows Increased Type II Collagen Synthesis in Osteoarthritis and Expression of Inhibin βA (Activin A), a Regulatory Molecule for Chondrocytes (2004)

We show that proteomic analysis can be applied to study cartilage pathophysiology. Proteins secreted by articular cartilage were analyzed by two-dimensional SDS-PAGE and mass spectrometry. Cartilage explants were cultured in medium containing [35S]methionine/cysteine to radiolabel newly synthesized proteins. To resolve the cartilage proteins by two-dimensional electrophoresis, it was necessary to remove the proteoglycan aggrecan by precipitation with cetylpyridinium chloride. 50-100 radiolabeled protein spots were detected on two-dimensional gels of human cartilage cultures. Of 170 silver-stained proteins identified, 19 were radiolabeled, representing newly synthesized gene products. Most of these were known cartilage constituents. Several nonradiolabeled cartilage proteins were also detected. The secreted protein pattern of explants from 12 osteoarthritic joints (knee, hip, and shoulder) and 14 nonosteoarthritic adult joints were compared. The synthesis of type II collagen was strongly up-regulated in osteoarthritic cartilage. Normal adult cartilage synthesized little or no type II collagen in contrast to infant and juvenile cartilage. Potential regulatory molecules novel to cartilage were identified; pro-inhibin betaA and processed inhibin betaA (which dimerizes to activin A) were produced by all the osteoarthritic samples and half of the normals. Connective tissue growth factor and cytokine-like protein C17 (previously only identified as an mRNA) were also found. Activin induced the tissue inhibitor for metalloproteinases-1 in human chondrocytes. Its expression was induced in isolated chondrocytes by growth factors or interleukin-1. We conclude that type II collagen synthesis in articular cartilage is down-regulated at skeletal maturity and reactivated in osteoarthritis in attempted repair and that activin A may be an anabolic factor in cartilage.
Investigation of dose reduction in neonatal radiography using specially designed phantoms and LiF:Mg,Cu,P TLDs (2003)

Many departments still do not use recommended radiographic parameters to X-ray neonates. Direct, accurate dose measurements of individual examinations may assist a department in justifying technique modifications that provide a substantial dose reduction without a significant loss of image quality. The aim of this study was to investigate dose reduction techniques for neonates in the intensive care unit. Alterations in beam energy (kVp and filtration) and collimation were investigated using specially designed phantoms mimicking a 700 g and 2000 g neonate, and ultrasensitive LiF:Mg,Cu,P thermoluminescence dosimeters (TLDs). Differences in entrance surface dose (ESD) and dose at depth (3 cm or 5 cm) were compared for two, overlapping fields centred individually on the chest and abdomen (Technique 1) and one large chest-abdomen field (Technique 2 or babygram). The large phantom was irradiated at 54 kVp, 60 kVp and 70 kVp without additional filtration and at 66 kVp and 70 kVp with a rare-earth hafnium filter. Focus-film distance (FFD) and mAs were adjusted to maintain optical density (OD) on each radiograph. The baseline dose at 54 kVp and 100 cm FFD was (46+/-2) micro Gy. Increasing the tube potential from 54 kVp to 70 kVp without additional filtration reduced the ESD by 27%. However, the addition of a 0.05 mm hafnium filter at 66 kVp further reduced the radiation dose by 13%, to produce an ESD of (28+/-2) micro Gy. All contrast details were observable at 66 kVp with hafnium filtration. Technique 1 may lead to an increase in effective dose due to field overlap, which diverges at depth, and increased scatter at the periphery of the fields.
Discovery of an Amylose-free Starch Mutant in Cassava (<i>Manihot esculenta</i> Crantz) (2007)

One of the objectives of the cassava-breeding project at CIAT is the identification of clones with special root quality characteristics. A large number of self-pollinations have been made in search of useful recessive traits. During 2006 harvests an S1 plant produced roots that stained brownish-red when treated with an iodine solution, suggesting that it had lower-than-normal levels of amylose in its starch. Colorimetric and DSC measurements indicated low levels (3.4%) and an absence of amylose in the starch, respectively. SDS-PAGE demonstrated the absence of GBSS enzyme in the starch from these roots. Pasting behavior was analyzed with a rapid visco-analyzer and resulted in larger values for peak viscosity, gel breakdown, and setback in the mutant compared with normal cassava starch. Solubility was considerably reduced, while the swelling index and volume fraction of the dispersed phase were higher in the mutant. No change in starch granule size or shape was observed. This is the first report of a natural mutation in cassava that drastically reduces amylose content in root starch.
A proline-to-histidine substitution at position 225 of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) sensitizes HIV-1 RT to BHAP U-90152. (1998)

Two mutant virus strains in which the novel P225H mutation appeared in a V106A reverse transcriptase (RT)-mutated genetic background upon treatment of human immunodeficiency virus type 1 (HIV-1) with quinoxaline S-2720 were isolated. Surprisingly, the addition of the P225H mutation to the V106A RT mutant genetic background resensitized the V106A RT mutant virus to the non-nucleoside RT inhibitor (NNRTI) BHAP U-90152, but not to other NNRTIs. Construction of both recombinant viruses and recombinant RTs containing the V106A, P225H and V106A+P225H mutations revealed that P225H was indeed responsible for the marked potentiation of the antiviral activity of BHAP against the P225H single-mutant virus and the V106A+P225H double-mutant virus when compared to wild-type and V106A single-mutant viruses, respectively. An explanation for the markedly increased sensitivity of the P225H mutant HIV-1 RT to BHAP and not to the other NNRTIs was provided by the unique features of the X-ray structure of the RT-BHAP complex.
Mitomycin-C and megestrol acetate in treatment of breast cancer refractory to hormonal and combination chemotherapy (1978)

Fifty patients with breast cancer refractory to endocrine manipulation and/or combination chemotherapy were treated with mitomycin-C 20 mg/m2 I.V. every 4-6 weeks and megestrol acetate 160 mg daily. Of 48 evaluable patients, 4% achieved complete remission (CR), 23% had partial remission (PR). Median duration of response for CR and PR was 7 months. Non-responders had a median survival of 2 months. The difference in survival of responders (both CR and PR) and non-responders was statistically significant at p less than 0.01 level. Attenuated doses of mitomycin-C were administered at increasing intervals due to cumulative myelosuppressive toxicity.
Using Perspective in 3D File Management: Rotating Windows and Billboarded Icons (2006)

The evaluation and comparison of 2D and 3D workspace environments is a hot topic. Much has been said concerning the promise of 3D workspaces but much less has been realised. Part of the problem appears to be the difficulty of developing 3D GUIs with high usabilities and effective navigation mechanisms. Many early environments simulated a 3D office but all suffered from a range of problems, from poor navigation to issues of spatial cognition. Indeed, most researchers now consider an office to be an inappropriate metaphor for an effective 3D computer environment. This paper describes the development of a 3D workspace based directly on the WIMP metaphor as opposed to a desktop or office metaphor. The environment uses rotating transparent 2D windows in a 3D world and presents icons as billboards.
Wordsworth's ‘Lucy’: Fiction or Fact? (1998)

Abstract This chapter addresses the question of whether Wordworth's ‘Lucy’ poems were fact or fiction. The poems amount to a core of five or six lyrics, supplemented by other poems or passages in which a young woman named Lucy is mentioned or some other factor suggests a connection with her. The chapter looks at the various references by name to Lucy in their original order — and, in the case of poems addressed to her, in their earliest known versions. It considers a piece of evidence standing solidly in the way of straightforwardly assuming Lucy to have been a real woman whom Wordsworth had formerly loved, which emerges in the final poem of the group, composed in 1802.
Organic Electrosynthesis (1984)

RETURN TO ISSUEPREVNewsNEXTOrganic ElectrosynthesisNew industrial uses for an old technology are spurred by advances in chemistry, engineering, and materialsROBERT JANSSONView Author Information MonsantoCite this: Chem. Eng. News 1984, 62, 47, 43–57Publication Date (Print):November 19, 1984Publication History Published online7 November 2010Published inissue 19 November 1984https://pubs.acs.org/doi/10.1021/cen-v062n047.p043https://doi.org/10.1021/cen-v062n047.p043newsACS PublicationsCopyright © 1984 American Chemical SocietyArticle Views25Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options SUBJECTS:Electrochemistry Get e-Alerts