gebhart/patrepeval huggingface dataset:
Inducible microglial nitric oxide synthase (1994)

Microglia are the only immunocompetent cells resident in the central nervous system which are capable of protecting the brain from infection and tumors. These resident macrophages possess a vast array of mechanisms for the destruction of bacteria and tumor cells. One of these mechanisms involves the generation of nitric oxide which can kill cells by inhibition of glycolysis, the TCA cycle and DNA synthesis. In this regard, we demonstrate, for the first time, that the inducible form of nitric oxide synthase (NOS) in microglia involves both cytosolic and membrane bound pools. Both pools of NOS were potently and stereo-specifically inhibited by NOS inhibitors. In addition, while these pools were unaffected by Ca2+, they were partially inhibited by calmodulin antagonists. These data would suggest that inducible NOS in lipopolysaccharide (LPS) treated microglia, constitutes two major compartments and may involve a novel isoform which is membrane associated. With regard to the possible physiological relevance for the membrane-bound NOS, we speculate that this presents an efficient means of supplying nitric oxide to the extracellular environment where it could gain rapid access to tumors and bacteria. This would result in inhibition of cellular function in these invading cells while limiting access of nitric oxide to the intracellular environment of microglia where NO could lead to depressed microglial function.
Using Dehydration to Preserve Fruits, Vegetables, and Meats (2008)

Why dry? Drying (dehydrating) food is one of the oldest and easiest methods of food preservation. Dehydration is the process of removing water or moisture from a food
Dressing Sponges Made of Chitosan and Chitosan - Alginate Fibrids (2008)

This paper presents a manufacturing process for biological chitosan and chitosan-alginate dressing sponges as well as their biological and physical-mechanical properties. The aim of the research was the preparation of such sponges based on chitosan and chitosan-alginate fibrids prepared according to a method elabo
Production and Characterization of Alginate Microcapsules Produced by a Vibrational Encapsulation Device (2008)

The optimization, through a Design of Experiments (DoE) approach, of a microencapsulation procedure for isolated neonatal porcine islets (NPI) is described. The applied method is based on the generation of monodisperse droplets by a vibrational nozzle. An alginate/polyornithine encapsulation procedure, developed and validated in our laboratory for almost a decade, was used to embody pancreatic islets. We analyzed different experimental parameters including frequency of vibration, amplitude of vibration, polymer pumping rate, and distance between the nozzle and the gelling bath. We produced calcium-alginate gel microbeads with excellent morphological characteristics as well as a very narrow size distribution. The automatically produced microcapsules did not alter morphology, viability and functional properties of the enveloped NPI. The optimization of this automatic procedure may provide a novel approach to obtain a large number of batches possibly suitable for large scale production of immunoisolated NPI for in vivo cell transplantation procedures in humans.
Initial Evaluation of <sup>11</sup>C-DPA-713, a Novel TSPO PET Ligand, in Humans (2009)

Studies in patient populations will help determine whether (11)C-DPA-713 provides better sensitivity for evaluating increased TSPO expression. This initial study in humans shows that (11)C-DPA-713 is a promising ligand for evaluating TSPO binding with PET.
Prothrombinase Components Can Accelerate Tissue Plasminogen Activator-catalyzed Plasminogen Activation (1995)

The enzymatic and cofactor subunits of human prothrombinase, factor Xa (FXa) and factor Va (FVa), respectively, were evaluated as modulators of Glu- and Lys-plasminogen (Pg) activation by tissue plasminogen activator (tPA). The data revealed that both FXa and FVa could accelerate tPA activity by as much as 60-fold for Lys-Pg and > 150-fold for Glu-Pg. This function of FVa depended on pretreatment with plasmin (Pn), whereas the FXa fibrinolytic cofactor activity was endogenous. In the native state, FVa was observed to inhibit the acceleration of Pn generation by FXa. These effects were dependent on Ca2+ and procoagulant phospholipid. Interactions between plasminogen and prothrombinase components were quantified. The apparent Kd for binding to FXa was 35 nM. Strikingly, the affinity between FVa and Pg was increased by approximately 2 orders of magnitude when the FVa was Pn-pretreated (Kd = 0.1 microM). These data cumulatively suggest a mechanism by which Pn production is coordinated with coagulation and localized to sites where procoagulant phospholipid is exposed on a cell surface.
Nonvolatile three-terminal operation based on oxygen vacancy drift in a Pt/Ta<sub>2</sub>O<sub>5−x</sub>/Pt, Pt structure (2013)

Nonvolatile three-terminal operation is demonstrated using a Pt/Ta2O5−x/Pt, Pt structure, by controlling oxygen vacancy drift to make/annihilate a conductive channel between a source and a drain. The as-fabricated device is in an off-state. Application of a positive gate bias moves oxygen vacancies in a Ta2O5−x layer towards a channel region, making the channel region conductive. The conductive channel remains even after unloading the gate bias. Application of a negative gate bias, which moves the oxygen vacancies back towards the gate electrode, is required to turn off the device. The device shows a high ON/OFF ratio of up to 106.
SEL120-34A is a novel CDK8 inhibitor active in AML cells with high levels of serine phosphorylation of STAT1 and STAT5 transactivation domains (2017)

Inhibition of oncogenic transcriptional programs is a promising therapeutic strategy. A substituted tricyclic benzimidazole, SEL120-34A, is a novel inhibitor of Cyclin-dependent kinase 8 (CDK8), which regulates transcription by associating with the Mediator complex. X-ray crystallography has shown SEL120-34A to be a type I inhibitor forming halogen bonds with the protein's hinge region and hydrophobic complementarities within its front pocket. SEL120-34A inhibits phosphorylation of STAT1 S727 and STAT5 S726 in cancer cells in vitro. Consistently, regulation of STATs- and NUP98-HOXA9- dependent transcription has been observed as a dominant mechanism of action in vivo. Treatment with the compound resulted in a differential efficacy on AML cells with elevated STAT5 S726 levels and stem cell characteristics. In contrast, resistant cells were negative for activated STAT5 and revealed lineage commitment. In vivo efficacy in xenotransplanted AML models correlated with significant repression of STAT5 S726. Favorable pharmacokinetics, confirmed safety and in vivo efficacy provide a rationale for the further clinical development of SEL120-34A as a personalized therapeutic approach in AML.
A note from the Editorial Board (2012)

From this year, Professor Seiji Ukai will step down from the managing editorial board of KRM. Seiji Ukai is a world leading expert in the ﬁeld of mathematical theories of kinetic equations. He is the ﬁrst one who proved the global existence of solutions to the space inhomogeneous Boltzmann equation in 1974, and he has been making important contributions to this area, including his series of recent works on the Boltzmann equation without angular cutoff. We are deeply indebted to the contributions that Seiji made to the area and the journal and wish him all the best in the future. <br><br> For more information please click the "Full Text" above.
Sodium Bisulfite (2003)

Clinical deficits associated with unintentional intrathecal injection of chloroprocaine likely resulted from a direct effect of the anesthetic, not the preservative. The data also suggest that bisulfite can reduce neurotoxic damage induced by intrathecal local anesthetic.
Search for kaonic nuclear state using p+p reaction (2009)

Fall prevention poses a major challenge to healthcare personnel. Fall prone patients must be accurately identified and staff must adhere to evidence-based practices that have distinct value for preventing falls. This article describes a Definitive Observation Unit (DOU) and its evidence-based fall-prevention protocol based on nationally recognized standards. Despite the adoption of the protocol, fall occurrence rates remained above California Nursing Outcomes Coalition benchmarks. There were variations among nurses, physicians and physical therapists in regard to the value of fall prevention program components such as pre-formatted orders, physical therapy referrals and documentation. This authors report results of a study using an evidence-based practice (EBP) framework for evaluating an interdisciplinary, multifactorial fall prevention protocol. Results indicated that staff champions and resources are essential elements for changing practices that are vital to fall reduction.
FSAN OAN-WG and future issues for broadband optical access networks (2001)

Network operators are aiming to provide a broadband access network to facilitate the next-generation telecom services. They have established the Full Services Access Networks (FSAN) group in order to find the best way to achieve early and cost-effective deployment of broadband optical access systems. They concluded that a single worldwide broadband access system should be investigated in the FSAN and then standardized in the international standards bodies such as the ITU-T. This article outlines the FSAN organization and the study targets for its Optical Access Network working group, and some key future study issues in terms of optical distribution network requirements and the required system functionalities of the B-PON system. It also describes its standardization strategy and the interaction between the FSAN and ITU-T.
Homogeneous assays based on deoxyribozyme catalysis (2000)

We report herein the first homogeneous assays based on the ribonuclease activity of a deoxyribozyme. The previously reported deoxyribozyme was covalently modified with biotin and used to assay biotin-binding interactions through changes in fluorescence upon substrate turnover. Deoxyribozymes with fluorescence-based reporting have the potential to serve as general analytical tools.
SNPStats: a web tool for the analysis of association studies (2006)

http://bioinfo.iconcologia.net/SNPstats. Source code for local installation is available under GNU license.
Genesis of Korotkoff sounds (1964)

Korotkoff sounds were produced in anesthetized dogs and studied in detail. The change in the pattern of blood flow was demonstrated by cinefluorographic technique. Various mechanisms producing Korotkoff sounds are discussed. It was demonstrated that heart sounds and Korotkoff sounds are distinct and separate entities since they are separable in time and are differently influenced by changing the site of the sensing element. These experiments demonstrate that turbulence occurred in flow (corresponding with Korotkoff sounds) despite the fact that the calculated Reynolds numbers were low. The vessel wall is not necessary to the production of Korotkoff sounds.
Design and synthesis of a novel family of semi-rigid ligands: versatile compounds for the preparation of 99mTc radiopharmaceuticals (2004)

Synthetic pathways to a range of novel semi-rigid tetradentate ligands, with sulfur, amido or amino donor groups, designed to coordinate technetium 99m have been developed. The technetium-99m complexes have been prepared and their stabilities in serum and by metathesis reaction via cysteine exchange reactions were compared. HPLC comparison of two (99m)Tc-complexes and their rhenium analogues led to the first proof of the nature of our radioactive complexes.
Maximum Likelihood Estimation of Multivariate Autoregressive-Moving Average Models. (1977)

Algorithms for computing the exact likelihood function of n successive observation vectors from an s-variate autoregressive moving average process of order (p,q) are developed. A quasi-Newton method is used to maximize the likelihood function with respect to the parameters of the process. Monte Carlo simulations are performed to compare the parameter estimates obtained by maximizing the exact likelihood function versus those obtained by maximizing various approximate forms of the likelihood function. (Author)
Hitless wavelength-selective switch with quadruple series-coupled microring resonators using multiple-quantum-well waveguides (2013)

We demonstrate a hitless wavelength-selective switch (WSS) based on InGaAs/InAlAs five-layer asymmetric coupled quantum well (FACQW) quadruple series-coupled microring resonators. The WSS is driven by the electric-field-induced change in refractive index in the FACQW core layer caused by the quantum-confined Stark effect (QCSE) for high-speed operation. The WSS with high-mesa waveguides is fabricated on a molecular beam epitaxy-grown wafer by dry etching. The fabricated WSS consists of four microrings, each with a round-trip length of 350 μm and five directional couplers with shallow grooves. A boxlike spectral response and hitless switching with higher extinction ratios than a double series-coupled microring resonator are successfully demonstrated. In addition, we propose the improvement of switching characteristics by controlling the coupling efficiencies at the directional couplers.
Unsupervised automation of photographic composition rules in digital still cameras (2004)

When taking pictures, professional photographers apply photographic composition rules, e.g. rule of thirds. The rule of thirds says to place the main subject's center at one of four places: at 1/3 or 2/3 of the picture width from left edge, and 1/3 or 2/3 of the picture height from the top edge. This paper develops low-complexity unsupervised methods for digital still cameras to (1) segment the main subject and (2) realize the rule-of-thirds. The main subject segmentation method uses the auto-focus filter, opens the shutter aperture fully, and segments the resulting image. These camera settings place the main subject in focus and blur the rest of the image by diffused light. The segmentation utilizes the difference in frequency content between the main subject and blurred background. The segmentation does not depend on prior knowledge of the indoor/outdoor setting or scene content. The rule-of-thirds method moves the centroid of the main subject to the closest of the four rule-of-thirds locations. We first define an objective function that measures how close the main subject placement obeys the rule-of-thirds, and then reposition the main subject in order to optimize the objective function. For multiple main subjects, the proposed algorithm could be extended to use rule-of-triangles by adding an appropriate constraint.
Estrogen replacement therapy I: a 10-year prospective study in the relationship to osteoporosis. (1979)

A 10-year, double-blind prospective study was undertaken to evaluate the effects of estrogen replacement therapy. The sample population consisted of 84 pairs of randomly chosen postmenopausal patients who were matched for age and diagnosis. One half of the patients received conjugated estrogens and cyclic progesterone, while the other half received placebo. Estrogen-treated patients whose therapy started within 3 years of menopause showed improvement or no increase in osteoporosis. Control patients demonstrate an increase in their osteoporosis.
The Effects of Feedback Filtering on Nasalization in Normal and Hypernasal Speakers (1979)

Two groups of subjects, one with normal speech and one with hypernasal speech, spoke while hearing their voices unfiltered, low-pass filtered with cut-off frequencies of 1000, 500, and 300 Hz and high-pass filtered with cut-off frequencies of 500, 1000, and 2000 Hz. Measurements of nasalization were made with a miniature accelerometer attached to the side of the subject's nose. Both groups of subjects decreased nasalization when hearing their voices low-pass filtered with a cut-off frequency of 300 Hz. This decrease was statistically significant. The results were interpreted as supporting the hypothesis that nasalization is under feedback control.
Breakdown Characteristics According to the Type & Gap of Rod-electrodes Using Imitation Air (2014)

In this paper the experiments of breakdown characteristics of rod-electrodes by pressure and gap change of imitation-air were described. The results are fundamental data for electric insulation design of distribution power facilities which will be studied and developed in the future. And we could make an environment friendly gas insulation material with mataining dielectric strength by imitation air which generates a lower lever of the global warming effect.
The effect of placement on yield for standard cell designs (2002)

The ability to improve the yield of integrated circuits through layout modification has been recognized and several techniques for yield enhanced routing and compaction have been developed. Yield improvement during routing is however, limited by the predetermined placement. It is conceivable therefore, that different placements of the modules (e.g., standard or custom cells) may lead to very different yield enhanced routings with different projected yields. This is conceptually similar to the effect that the floorplanning of the entire chip has on the yield, but while chip floorplanning deals with the major building blocks, placement deals with the modules within an individual block. Yield enhanced placement of modules has not been attempted before mainly due to the difficulty of estimating the yield of the block before the routing is done. Recently, a technique for estimating the yield prior to the routing has been developed making it possible to modify the placement in order to achieve higher yield. The goals of this paper are to investigate the effect that placement has on the projected yield and to modify a standard cell placement algorithm so that yield becomes a design objective.
<title>Bremsstrahlung imaging with the gamma camera</title> (1992)

A conventional gamma camera is used for the external imaging of bremsstrahlung generated from pure beta-emitters such as phosphorous-32 (32P). Tomographic images of a cylindrical phantom filled with water and containing four cylindrical sources of varying diameter are recorded using two collimators with symmetrical aperture configuration but different bore-lengths. The resolution of the system is comparable to single photon emitters for both collimaters; FWHM approximately 1.8 cm and FWTM approximately 2.9 cm. An effective linear attenuation coefficient of 0.14 cm-1 for 32P, calculated from isolated spherical sources in water, is used with the post-reconstruction Chang algorithm to correct the tomographic images. The use of a broad energy window and the symmetric apertures of the collimators yields an approximately radially symmetric, shift invariant, and stationary point-spread-function with distance from the collimator face as required for the use of image restoration filters. A new filter is proposed which shares the advantages of both neural network for deconvolution and advanced nonlinear filtering for noise removal and edge enhancement. The new filter compares favorably with the Wiener for image restoration and improves the conditions for quantitative measurements with the gamma camera. In addition, its application for image restoration does not require the knowledge of the object and noise power spectra and the serious problems (ring effects and noise overriding) associated with the inverse operation encountered in the Wiener filter are avoided.
Vitamin D Receptor Expression in Human Muscle Tissue Decreases With Age (2004)

Intranuclear immunostaining of the VDR was present in muscle biopsy specimens of all orthopedic patients. Older age was significantly associated with decreased VDR expression, independent of biopsy location and serum 25-hydroxyvitamin D levels.
Structure and function of Rv0130, a conserved hypothetical protein from <i>Mycobacterium tuberculosis</i> (2006)

Abstract A large fraction of the Mycobacterium tuberculosis genome codes for proteins of unknown function. We here report the structure of one of these proteins, Rv0130, solved to a resolution of 1.8 å. The Rv0130 monomer features a single hotdog fold composed of a highly curved β‐sheet on top of a long and a short α‐helix. Two monomers in turn pack to form a double‐hotdog‐folded homodimer, similar to a large group of enzymes that use thiol esters as substrates. Rv0130 was found to contain a highly conserved R ‐specific hydratase motif buried deeply between the two monomers. Our biochemical studies show that the protein is able to hydrate a short trans ‐2‐enoyl‐coenzyme A moiety with a k cat of 1.1 × 10 2 sec −1 . The importance of the side chains of D40 and H45 for hydratase activity is demonstrated by site‐directed mutagenesis. In contrast to many hotdog‐folded proteins, a proline residue distorts the central helix of Rv0130. This distortion allows the creation of a long, curved tunnel, similar to the substrate‐binding channels of long‐chain eukaryotic hydratase 2 enzymes.
Next generation sequencing (NGS) in wild type GISTs. (2017)

e22507 Background: The majority driven mutation of GIST are located in KIT and PDGFRA. A proportion of the remaining 10% of GIST without KIT or PDGFRA mutations called wild type GIST (wt-GIST). It is poor response to imatinib, sunitinib or regorafenib in these wt-GIST patients. It is lack of precise drug target of wt-GIST. We analyzed next generation exome sequencing (NGS) results in wt-GISTs. Methods: Whole exome sequencing was performed on freezing tumor tissue and peripheral blood DNA with 100X sequencing depth. The low frequency somatic mutation was confirmed by matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) and Sanger sequencing. This study was approved by the ethical committee of Sun Yat-Sen University Cancer Center. Results: A total of 11 wt-GIST samples were analyzed. ROS1 (ROS Proto-Oncogene 1, Receptor Tyrosine Kinase) was mutated in one CD117 negative patients with 5.3% mutation frequency of c. 364G > A (p. A122T). Sanger sequencing couldn’t found the ROS1 mutated in tumor tissue. But this low frequency somatic mutation was verified by MALDI-TOF. Conclusions: This is the first report showed a new ROS1 somatic mutation in wt-GIST. Our results indicated that ROS1 could be a new possible driven mutation in wt-GIST. ROS1 rearrangement have been described in a subset of non-small-cell lung cancers (NSCLC). Crizotinib shows a potent curative effect in ROS1 rearrangement NSCLC. Therefore, crizotinib might be an appropriate drug to GIST patients with mutated ROS1.
A K/Ka-band distributed power amplifier with capacitive drain coupling (1988)

A 14- to 37-GHz GaAs MMIC distributed power amplifier is discussed. The amplifier has three FETs of varying periphery, all capacitively coupled to the gate line. The drain of the FET nearest the output is capacitively coupled to the drain line to increase output power. A gain of 4 to 5 dB has been achieved from 14 to 37 GHz. Output power of 20 dBm or greater has been demonstrated at frequencies up to 33 GHz at 1-dB gain compression. A maximum 1-dB gain-compressed output power of 23.5 dBm (220 mW) has been measured at 36 GHz. The circuit is completely monolithic, with all bias and matching circuitry included on the chip.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>