gebhart/patrepeval huggingface dataset:
Evaluation of a Hands-Free Unit During Double-Talk (2006)

The double-talk performance of a hands-free speech communication system is crucial to the overall quality. This paper presents a method to evaluate double-talk performance of conference phones and speakerphones. The method measures loudness, clipping and the amount of echo during double-talk.
Automated Layup of Sheet Prepregs on Complex Moulds (2016)

A new two-stage method for the automated manufacture of high performance composites components is presented which aims to combine the capacity for forming complex shapes of Hand Layup with the speed of existing automated systems. In the first stage of the new process plies are formed into the approximate shape of the mould using a press mechanism. They are then passed onto a layup stage which uses multiple end effectors controlled by a six axis robot to stick the plies down onto the mould. This is the first time an automated process has been capable of forming sheets of woven prepreg onto truly complex moulds while maintaining a high level of fibre alignment. This work represents a condensed version of the second half of the thesis by the author entitled ‘The evolution and automation of sheet prepreg layup’.
Performance Analysis of IDF Relaying M2M Cooperative Networks over N-Nakagami Fading Channels (2015)

Exact average bit error probability (BEP) expressions for mobile-relay-based mobile-to-mobile (M2M) cooperative networks with incremental decode-and-forward (IDF) relaying over N-Nakagami fading channels are derived in this paper. The average BEP performance under different conditions is evaluated numerically to confirm the accuracy of the analysis. Results are presented which show that the fading coefficient, the number of cascaded components, the relative geometrical gain, and the power allocation parameter have a significant influence on the average BEP performance.
Large-scale pan-cancer analysis reveals broad prognostic association between TGF-β ligands, not Hedgehog, and GLI1/2 expression in tumors (2020)

GLI1 expression is broadly accepted as a marker of Hedgehog pathway activation in tumors. Efficacy of Hedgehog inhibitors is essentially limited to tumors bearing activating mutations of the pathway. GLI2, a critical Hedgehog effector, is necessary for GLI1 expression and is a direct transcriptional target of TGF-β/SMAD signaling. We examined the expression correlations of GLI1/2 with TGFB and HH genes in 152 distinct transcriptome datasets totaling over 23,500 patients and representing 37 types of neoplasms. Their prognostic value was measured in over 15,000 clinically annotated tumor samples from 26 tumor types. In most tumor types, GLI1 and GLI2 follow a similar pattern of expression and are equally correlated with HH and TGFB genes. However, GLI1/2 broadly share prognostic value with TGFB genes and a mesenchymal/EMT signature, not with HH genes. Our results provide a likely explanation for the frequent failure of anti-Hedgehog therapies in tumors, as they suggest a key role for TGF-β, not Hedgehog, ligands, in tumors with elevated GLI1/2-expression.
IoT based smart parking system (2016)

In recent times the concept of smart cities have gained grate popularity. Thanks to the evolution of Internet of things the idea of smart city now seems to be achievable. Consistent efforts are being made in the field of IoT in order to maximize the productivity and reliability of urban infrastructure. Problems such as, traffic congestion, limited car parking facilities and road safety are being addressed by IoT. In this paper, we present an IoT based cloud integrated smart parking system. The proposed Smart Parking system consists of an on-site deployment of an IoT module that is used to monitor and signalize the state of availability of each single parking space. A mobile application is also provided that allows an end user to check the availability of parking space and book a parking slot accordingly. The paper also describes a high-level view of the system architecture. Towards the end, the paper discusses the working of the system in form of a use case that proves the correctness of the proposed model.
Image-based bidirectional scene reprojection (2011)

We introduce a method for increasing the framerate of real-time rendering applications. Whereas many existing temporal upsampling strategies only reuse information from previous frames, our bidirectional technique reconstructs intermediate frames from a pair of consecutive rendered frames. This significantly improves the accuracy and efficiency of data reuse since very few pixels are simultaneously occluded in both frames. We present two versions of this basic algorithm. The first is appropriate for fill-bound scenes as it limits the number of expensive shading calculations, but involves rasterization of scene geometry at each intermediate frame. The second version, our more significant contribution, reduces both shading and geometry computations by performing reprojection using only image-based buffers. It warps and combines the adjacent rendered frames using an efficient iterative search on their stored scene depth and flow. Bidirectional reprojection introduces a small amount of lag. We perform a user study to investigate this lag, and find that its effect is minor. We demonstrate substantial performance improvements (3--4x) for a variety of applications, including vertex-bound and fill-bound scenes, multi-pass effects, and motion blur.
A harmonic reference frame based current controller for active filter (2002)

This paper presents a new method of current regulation for active filters based on the idea of compensating each harmonic current at its own rotating reference frame. Because the harmonic current to be compensated for is DC in the steady-state within a rotating reference frame that is rotating in the same direction and at the speed of the harmonic, the steady state error of each harmonic compensated for can be eliminated. Eventually, the harmonics in the line current can be cancelled out. In real situations, there are many unbalanced utility voltage conditions, so the active filters can compensate properly under these conditions too. The proposed current controller can work under unbalanced voltage conditions. The experimental results illustrate the effectiveness of the proposed method.
Inertial navigation systems analysis (1971)

This volume offers the avionic systems engineer a fundamental exposition of the mechanization and error analysis of inertial navigation systems. While the material is applicable to spacecraft and undersea navigation, emphasis is placed upon terrestrial applications on or slightly above the earth's surface. As a result, practical considerations are geared toward those aircraft navigation systems of particular current interest. Extensive use is made of perturbation techniques to develop linearized system equations, whose solutions closely approximate those obtained by nonlinear differential equations. A unified error analysis technique is developed that is applicable to virtually all system configurations. The technique provides a greatly simplified method for comparing the performance of competing system configurations.
Textbook of Dental Radiology (1984)

Rev. ed. of: Textbook of dental radiography. c1973
Quality of Life and Attitudes Toward Aging Among Older Women in Turkey (2012)

This quantitative and descriptive study investigated the quality of life (QOL) and attitudes toward aging of 270 older women in Sanliurfa Province, Turkey. The Turkish versions of the World Health Organization Quality of Life Instrument—Older Adults Module and the World Health Organization—Attitudes Toward Aging Questionnaire were administered to the participants. The results indicated that there was significant relationship between the women’s QOL and attitudes toward aging. Two dimensions of attitudes toward aging (physical change and psychological growth) were significant predictors of QOL in the women. It was also found that literacy and happiness affected some dimensions of the women’s QOL and some subscales of attitudes toward aging.
Trajectory planning for coordinated motion of a robot and a positioning table. I. Path specification (1990)

Coordinating the tool (robot) and workpiece (positioning table) motion in continuous manufacturing processes such as sealing, welding, and laser cutting offers several advantages over the motion of only the tool or workpiece. Better utilization of the speed and workspace characteristics of the two devices and improvement in tracking accuracy at sharp corners in the path are some of the merits of this approach. In coordinated motion, the two devices are simultaneously moved to track a given path, and two strategies are developed for coordinating their motion, where each is dependent on the given path information. The first strategy is applicable to any type of path and resolves the motion by splitting the displacement between any two points on the path into segments moved by the robot and the table. The robot and the table move in opposite directions in this strategy. The second strategy is applicable to sharp cornered paths and resolves the given path into two smooth paths. The first path is a double clothoid curve, whereas the second path is a tangential straight line path. The table executes a local motion around the corner in this strategy, whereas the robot is moved at all times. The uniqueness of this strategy in constructing the original corner path is proved. The proposed strategies are shown to be applicable to other coordinated motion systems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Phase equilibria and diffusion coefficients in the Fe-Zn binary system (2019)

Phase diagram and diffusion coefficients of the Fe-Zn binary system are required to predict and control the microstructure of galvanized zinc coatings and thus were systematically investigated in the temperature range from 700 to 1100 °C using nine novel Fe/Zn liquid-solid diffusion couples (LSDCs). The equilibrium compositions of the α and Γ phases of the Fe-Zn system were determined and agree well with the recently established Fe-Zn phase diagram. The extracted interdiffusion coefficients in α-Fe at temperatures between 700 and 1100 °C and in Γ at 750 and 700 °C using the forward-simulation analysis (FSA) extend the experimental interdiffusivity measurements to the whole solubility range of these two phases. Three impurity diffusion coefficients of Zn in paramagnetic α-Fe were also determined by the FSA and show good agreement with the literature data. The temperature dependence of the Zn impurity diffusion coefficients in both the paramagnetic and ferromagnetic α-Fe phases across the Curie temperature TC was established by analyzing the reliable experimental results as well as by density functional theory (DFT) calculations. The newly measured phase equilibrium and diffusivity data provide reliable inputs for future thermodynamic and kinetic modeling of the Fe-Zn system.
Target‐Catalyzed Transfer Reactions for the Amplified Detection of RNA (2008)

Strong signals: The RNA-catalyzed transfer of a biotin reporter was used to preamplify a signal that was detected in an enzyme-based readout, thereby increasing its sensitivity. The advantages of combining the covalent attachment of biotin and preamplification were demonstrated by the detection of 500 attomol HIV RNA. The flexibility requirements of DNA- and RNA-catalyzed transfer reactions were tested. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z801355_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
On the delay statistics of an aggregate of SR-ARQ packets over Markov channels with finite round-trip delay (2004)

In this paper, we investigate the delay statistics of an aggregate of fully reliable selective-repeat ARQ packets. The sender transmits packets whose error process is characterized by means of a two-state discrete time Markov channel (DTMC). At the receiver, these packets are checked for errors and ACK/NACK messages are sent back to the sender accordingly. No errors are accounted for in the reverse channel. The feedback message is assumed to be known at the transmitter m channel slots (round-trip delay) after the packet transmission started. An appropriate Markov model has been previously developed in order to find the exact statistics of the delays experienced by ARQ packets. This work presents an extension of the analysis that computes the delay statistics of an aggregate of ARQ packets. This is achieved without increasing the model complexity and allows useful considerations from the point-of-view of higher level protocols.
ERK Activation in CAR T Cells Is Amplified by CD28-Mediated Increase in CD3ζ Phosphorylation (2020)

Chimeric antigen receptors (CARs) are engineered receptors that mediate T cell activation. CARs are comprised of activating and co-stimulatory intracellular signaling domains derived from endogenous T cells that initiate signaling required for T cell activation, including ERK activation through the MAPK pathway. Understanding the mechanisms by which co-stimulatory domains influence signaling can help guide the design of next-generation CARs. Therefore, we constructed an experimentally validated computational model of anti-CD19 CARs in T cells bearing the CD3ζ domain alone or in combination with CD28. We performed a systematic analysis to explore the different mechanisms of CD28 co-stimulation on the ERK response time. Comparing these model simulations with experimental data indicates that CD28 primarily influences ERK activation by enhancing the phosphorylation kinetics of CD3ζ. Overall, we present a mechanistic mathematical modeling framework that can be used to gain insights into the mechanism of CAR T cell activation and produce new testable hypotheses.
System A Transporter SAT2 Mediates Replenishment of Dendritic Glutamate Pools Controlling Retrograde Signaling by Glutamate (2008)

Glutamate mediates several modes of neurotransmission in the central nervous system including recently discovered retrograde signaling from neuronal dendrites. We have previously identified the system N transporter SN1 as being responsible for glutamine efflux from astroglia and proposed a system A transporter (SAT) in subsequent transport of glutamine into neurons for neurotransmitter regeneration. Here, we demonstrate that SAT2 expression is primarily confined to glutamatergic neurons in many brain regions with SAT2 being predominantly targeted to the somatodendritic compartments in these neurons. SAT2 containing dendrites accumulate high levels of glutamine. Upon electrical stimulation in vivo and depolarization in vitro, glutamine is readily converted to glutamate in activated dendritic subsegments, suggesting that glutamine sustains release of the excitatory neurotransmitter via exocytosis from dendrites. The system A inhibitor MeAIB (alpha-methylamino-iso-butyric acid) reduces neuronal uptake of glutamine with concomitant reduction in intracellular glutamate concentrations, indicating that SAT2-mediated glutamine uptake can be a prerequisite for the formation of glutamate. Furthermore, MeAIB inhibited retrograde signaling from pyramidal cells in layer 2/3 of the neocortex by suppressing inhibitory inputs from fast-spiking interneurons. In summary, we demonstrate that SAT2 maintains a key metabolic glutamine/glutamate balance underpinning retrograde signaling by dendritic release of the neurotransmitter glutamate.
A Convenient Synthesis of Aldehydes by Rearrangement of Cyclic Epoxides with Lithium Bromide on Alumina (1988)

Epoxides can be converted effectively to aldehydes by rearrangement with lithium bromide supported on alumina. In the case of the alicyclic epoxides, ring contracted cycloalkanecarbaldehydes can be formed. The conversion is achieved by gas-phase reaction or in toluene as solvent.
New job classes for fully automated reticle and sorter dispatch (2005)

The function to support automated lot dispatch, transport, performing process and data collection for fully automated fab operation has been enhanced following new 300 mm standards and requirements in Manufacturing Execution System (MES) along with relative components. However, fully automated reticle dispatch and dispatching FOUP to wafer sorter has not been implemented well. This paper introduces new job classes to support automated reticle dispatch and sorter dispatch
Ultraviolet ozone oxidation of Si surface studied by photoemission and surface infrared spectroscopy (1992)

It has previously been shown that ultraviolet (UV) ozone oxidation can be utilized for removing carbon contaminants on Si surfaces and forming a thin oxide film which serves as a protective overlayer for chemical attack. In this study, the UV ozone oxidation of a Si surface has been investigated using photoemission spectroscopy with synchrotron radiation and surface infrared spectroscopy in the multiple internal reflection mode. It is shown that during UV ozone oxidation a thin SiO2 film approximately 5 Å thick, which presumably corresponds to one monolayer of six-member rings of SiO4 tetrahedra, is initially formed and subsequently slow oxidation occurs. It is suggested that the formation of this 5-Å-thick oxide film is the key to protecting the Si substrate surface from the adsorption of impurities which would occur if the bare Si surface were exposed to air.
TCH-346 (Novartis). (2000)

TCH-346, an anti-apoptotic compound, is under development by Novartis for the potential treatment of Parkinson's disease (PD) and motor neuron disease [271447,342937]. By September 1999, phase I clinical trials for PD were underway [342937]. The compound was discovered in a screen for molecules with both norepinephrine uptake and MAO inhibiting properties but, although it had anti-apoptotic properties, it did not inhibit MAOA or MAO-B [333136,332004]. The compound increases lifespan in the progressive motorneuropathy mouse model and prevents ischemia in models of ischemia and seizure [288893]. In vivo, it shows neurorescuing and anti-apoptotic properties in PC12 cells and cerebellar granule cells, among others, at concentrations of 0.1 pM to 10 microM, suggesting that its action might prove potentially useful against Alzheimer's and/or Parkinson's disease [332004]. The compound has also shown neurorescuing properties in rat pups after axotomy, rat hippocampal CA1 neurons after transient ischemia/hypoxia and mouse nigral dopaminergic (DA) neurons after treatment with MPTP in doses ranging between 0.0003 and 0.1 mg/kg po or sc, depending on the model [333136]. Data presented by the University of Nijmengen and the Free University of Amsterdam show that TCH-346 improves the behavioral and enzymatic outcome in the rat 6-OH-dopamine model of Parkinson's disease. TCH-346 (0.0014 mg/kg sc bid) prevented abnormal stepping (open field test) and prevented increases in fore and hind-paw retraction time. TCH-346 also improved acquisition in the Morris water maze task and, at doses between 0.0014 and 0.14 mg/kg, prevented reduction in tyrosine hydroxylase immunoreactivity [345259]. Affinity binding studies with TCH-346 showed that GAPDH is the target [294902,283200]. Differential display RT-PCR also showed that protein-isoaspartyl-methyl transferase is induced by the drug [283200].
Polymerase chain reaction engineering (1997)

A mathematical model for polymerase chain reaction (PCR) is developed, taking into account the three steps in this process: melting of DNA; primer annealing; and DNA synthesis (polymerization). Activity and deactivation of the polymerase enzyme as a function of temperature is incorporated in the kinetic model to get a better understanding of the amplification of DNA. Computer simulation of the model is carried out to determine the effects of various parameters, such as the cycle number, initial DNA concentration (copynumber), initial enzyme concentration, extension time, temperature ramp, and enzyme deactivation on the DNA generation. (c) 1997 John Wiley & Sons, Inc. Biotechnol Bioeng 55: 359-366, 1997.
Smads as muscle biomarkers in amyotrophic lateral sclerosis (2014)

These data indicate that Smad1, 5, 8 mRNA and protein levels, as well as Smad phosphorylation, are elevated in ALS muscle and could potentially serve as markers of disease progression or regression.
Elements of Friction Theory and Nanotribology (2015)

Combining the classical theories of contact mechanics and lubrication with the study of friction on the nanometer range, this multi-scale book for researchers and students alike guides the reader deftly through the mechanisms governing friction processes, based on state-of-the-art models and experimental results. The first book in the field to incorporate recent research on nanotribology with classical theories of contact mechanics, this unique text explores atomic scale scratches, non-contact friction and fishing of molecular nanowires as observed in the lab. Beginning with simple key concepts, the reader is guided through progressively more complex topics, such as contact of self-affine surfaces and nanomanipulation, in a consistent style, encompassing both macroscopic and atomistic descriptions of friction, and using unified notations to enable use by physicists and engineers across the scientific community.
Functional Interaction of Aurora-A and PP2A during Mitosis (2007)

Entry into mitosis is a highly regulated process, promoted by the activated Cyclin B1/Cdk1 complex. Activation of this complex is controlled, in part, by the protein kinase Aurora-A, which is a member of a multigenic serine/threonine kinase family. In normal cells, Aurora-A activity is regulated, at least in part, by degradation through the APC-ubiquitin-proteasome pathway. It has recently been proposed that, in Xenopus, Aurora-A degradation can be inhibited by phosphorylation. It would thus be expected that a phosphatase activity would release this blockade at the end of mitosis. Here, we have shown that the protein phosphatase PP2A and Aurora-A are colocalized at the cell poles during mitosis in human cells and interact within the same complex. Using the PP2A inhibitor okadaic acid and an RNAi approach, we have shown that this interaction is functional within the cell. PP2A/Aurora-A interaction is promoted by an S51D mutation in Aurora-A and inhibited by a phosphomimetic peptide centered around Aurora-A S51, thereby strongly suggesting that PP2A controls Aurora-A degradation by dephosphorylating serine 51 in the A box of the human enzyme.
Tau and Aβ42 in Cerebrospinal Fluid from Healthy Adults 21–93 Years of Age: Establishment of Reference Values (2001)

These reference values can be applied when using CSF-tau and CSF-Abeta42 in clinical practice.
Polydopamine/hydroxyapatite nanowire-based bilayered membrane for photothermal-driven membrane distillation (2020)

In developing countries and resource-limited regions, where no power infrastructure is available, photothermal-driven membrane distillation (PMD) has been recognized as an attractive and sustainable technology for freshwater generation.