gebhart/patrepeval huggingface dataset:
Isolation and sequence analysis of a cDNA encoding rat liver α-<scp>l</scp>-fucosidase (1989)

cDNA clones for alpha-L-fucosidase were isolated from a rat liver lambda gt11 expression library by using both monospecific polyclonal antibodies against the affinity-purified enzyme and biotinylated rat liver fucosidase cDNA sequences as probes. The largest clone, lambda FC9, contained a 1522 bp full-length cDNA insert (FC9) that encoded the 434-amino acid-residue subunit (Mr 50439) of rat liver alpha-L-fucosidase. A putative signal peptide 28 amino acid residues in length preceded the sequence for the mature protein. In addition, FC9 specified for 11 nucleotide residues of 5' untranslated sequence, 78 nucleotide residues of 3' untranslated sequence and a poly(A) tail. The deduced amino acid sequence from FC9 in conjunction with the experimentally determined N-terminus of the mature enzyme suggested that rat liver fucosidase did not contain a pro-segment. However, there was the possibility of limited N-terminal processing (one to five amino acid residues) having occurred after removal of the predicted signal peptide. Amino acid sequences deduced from FC9 were co-linear with amino acid sequences measured at the N-terminus of purified fucosidase and on two of its CNBr-cleavage peptides. An unusual aspect of rat liver alpha-L-fucosidase protein structure obtained from the FC9 data was its high content of tryptophan (6%). The coding sequence from FC9 showed 82% sequence identity with that from a previously reported incomplete human fucosidase sequence [O'Brien, Willems, Fukushima, de Wet, Darby, DiCioccio, Fowler & Shows, (1987) Enzyme 38, 45-53].
Evaluation of Paeonol Skin-Target Delivery from Its Microsponge Formulation: In Vitro Skin Permeation and In Vivo Microdialysis (2013)

The aim of the present study was to design a novel topical skin-target drug-delivery system, the paeonol microsponge, and to investigate its drug-release patterns in dosage form, both in vitro and in vivo. Paeonol microsponges were prepared using the quasi-emulsion solvent-diffusion method. In vitro release studies were carried out using Franz diffusion cells, while in vivo studies were investigated by microdialysis after the paeonol microsponges were incorporated into a cream base. In vitro release studies showed that the drug delivered via microsponges increased the paeonol permeation rate. Ex vivo drug-deposition studies showed that the microsponge formulation improved drug residence in skin. In addition, in vivo microdialysis showed that the values for the area under the concentration versus time curve (AUC) for the paeonol microsponge cream was much higher than that of paeonol cream without microsponges. Maximum time (Tmax) was 220 min for paeonol microsponge cream and 480 min for paeonol cream, while the half-life (t1/2) of paeonol microsponge cream (935.1 min) was almost twice that of paeonol cream (548.6 min) in the skin (n = 3). Meanwhile, in the plasma, the AUC value for paeonol microsponge cream was half that of the paeonol cream. Based on these results, paeonol-loaded microsponge formulations could be a better alternative for treating skin disease, as the formulation increases drug bioavailability by lengthening the time of drug residence in the skin and should reduce side-effects because of the lower levels of paeonol moving into the circulation.
LunaNet: a Flexible and Extensible Lunar Exploration Communications and Navigation Infrastructure (2020)

NASA has set the ambitious goal of establishing a sustainable human presence on the Moon. Diverse commercial and international partners are engaged in this effort to catalyze scientific discovery, lunar resource utilization and economic development on both the Earth and at the Moon. Lunar development will serve as a critical proving ground for deeper exploration into the solar system. Space communications and navigation infrastructure will play an integral part in realizing this goal. This paper provides a high-level description of an extensible and scalable lunar communications and navigation architecture, known as LunaNet. LunaNet is a services network to enable lunar operations. Three LunaNet service types are defined: networking services, position, navigation and timing services, and science utilization services. The LunaNet architecture encompasses a wide variety of topology implementations, including surface and orbiting provider nodes. In this paper several systems engineering considerations within the service architecture are highlighted. Additionally, several alternative LunaNet instantiations are presented. Extensibility of the LunaNet architecture to the solar system internet is discussed.
Determination Of Capillary Displacement Pressure And Representative Average Capillary Pressure Vs. Depth In Shally Sandstones From Well Logs (1981)

This research presents a method whereby the capillary displacement pressure Pcd and the representative average capillary pressure in shaly sandstone reservoirs exhibits continuous information vs. depth from well logs. By the aid of special core analysis, correlation functions were obtained that relate the capillary characteristics of the reservoir rock to its lithologic development. Since the lithologic influence factor is a well log-derived parameter the correlations then were used to determine by means of well logs the capillary displacement and average capillary pressures for borehole sections where special core analysis is not available. This technique has been developed and applied to the shaly sandstone reservoir of the Sarir oil field in Libya.
An Overview of Data-Driven Techniques for IT-Service-Management (2018)

High availability of information technology (IT)-applications and -infrastructure components is a significant factor for the success of organizations because more and more business processes depend entirely on IT-services. The result is that the complexity of IT-environments is permanently increasing and therefore cost intensive maintenance processes become more difficult. Several frameworks for IT-service-management like IT Infrastructure Library bundle established best practices to support the task of IT-service operating. This paper provides an overview of data-driven techniques, which can be used in addition to the standards of best practice frameworks to improve reactive and proactive maintenance tasks. We present a selection of different machine learning and statistical methods from a theoretical and practical perspective, which enable detailed insights into the IT-environment status. Furthermore, we present different approaches for the analysis of IT-service tickets, which are the primary communication path between the customer and service provider in case of issues. These methods enhance the resolution-finding process by a higher automatization level or by improvement of the situational understanding in case of root cause analysis and problem determination. Moreover, prediction of the future status allows the initiation of proactive actions to possibly prevent critical situations before their occurrence; existing methods, their potentials, and shortcomings as well are in the center of this paper. We close our overview with a systematic guide for practitioners to select the proper method for their setting, based on a series of questions about the application at hand.
Integration of LiDAR and stereoscopic imagery for route corridor surveying (2007)

Transportation networks are, typically, one of the most economic valuable resources for any nation requiring a large percentage of GDP to build and maintain. These route corridors attract their own unique set of spatial information requirements in terms of overall management including planning, engineering and operation. Various disciplines within a road management agency require high quality, spatial data of objects and features occurring along these networks from road infrastructure, sub-surface pavement condition through to modelling noise. This paper examines the integration of relatively novel sensor data against some pressing spatial information requirements for a small European road management agency.\nLiDAR systems are widely available and now used to record data from both aerial and terrestrial survey platforms. One of the chief LiDAR outputs are X,Y,Z points enabling a reliable 2.5-D geometric surface to be produced. Stereoscopic imagery is also collected from similar airborne and terrestrial mobile platforms. Both provide different datasets in terms of their respective optical and geometric properties. For example, stereoscopic cameras mounted on a survey vehicle record different data compared to LiDAR mounted near vertically on an airborne platform. Airborne LiDAR provides a more comprehensive geometric record whereas stereoscopic imagery can be used to provide a more comprehensive visual descriptor of the immediate route corridor. Acquisition systems for both sensors are relatively well understood and developed. Both systems collect large volumes of data that require a significant amount of data processing in order to produce useful information. A more efficient result can be achieved by integrating these two datasets within a GIS. The preliminary results of integration of airborne LiDAR with ground based stereo imaging systems are presented. How well this integration satisfies the growing spatial information requirements of the road agency are also examined.
Stereoselective synthesis of stable isotope‐labeled L‐α‐amino acids: Chemomicrobiological synthesis of <sup>13</sup>C‐ and <sup>2</sup>H‐labeled L‐cysteine (1991)

Abstract Tryptophan synthase catalyzes the nucleophilic replacement of the hydroxyl group at C‐3 of L‐serine. This enzyme can use benzyl mercaptan as a nucleophile in the conversion of serine to S‐benzyl‐L‐cysteine which is deblocked by treatment with sodium in liquid ammonia to yield L‐cysteine. A strain of E. coli engineered to overproduce tryptophan synthase was used in the conversion of L‐serine to L‐cysteine. Labeled serine was prepared biosynthetically as described previously.
Delete, Retrieve, Generate: A Simple Approach to Sentiment and Style Transfer (2018)

We consider the task of text attribute transfer: transforming a sentence to alter a specific attribute (e.g., sentiment) while preserving its attribute-independent content (e.g., changing "screen is just the right size" to "screen is too small"). Our training data includes only sentences labeled with their attribute (e.g., positive or negative), but not pairs of sentences that differ only in their attributes, so we must learn to disentangle attributes from attribute-independent content in an unsupervised way. Previous work using adversarial methods has struggled to produce high-quality outputs. In this paper, we propose simpler methods motivated by the observation that text attributes are often marked by distinctive phrases (e.g., "too small"). Our strongest method extracts content words by deleting phrases associated with the sentence's original attribute value, retrieves new phrases associated with the target attribute, and uses a neural model to fluently combine these into a final output. On human evaluation, our best method generates grammatical and appropriate responses on 22% more inputs than the best previous system, averaged over three attribute transfer datasets: altering sentiment of reviews on Yelp, altering sentiment of reviews on Amazon, and altering image captions to be more romantic or humorous.
Enzymatic processing of collagen IV by MMP‐2 (gelatinase A) affects neutrophil migration and it is modulated by extracatalytic domains (2006)

Proteolytic degradation of basement membrane influences the cell behavior during important processes, such as inflammations, tumorigenesis, angiogenesis, and allergic diseases. In this study, we have investigated the action of gelatinase A (MMP-2) on collagen IV, the major constituent of the basement membrane. We have compared quantitatively its action on the soluble forms of collagen IV extracted with or without pepsin (from human placenta and from Engelbreth-Holm-Swarm [EHS] murine sarcoma, respectively). The catalytic efficiency of MMP-2 is dramatically reduced in the case of the EHS murine sarcoma with respect to the human placenta, probably due to the much tighter packing of the network which renders very slow the speed of the rate-limiting step. We have also enquired on the role of MMP-2 domains in processing collagen IV. Addition of the isolated collagen binding domain, corresponding to the fibronectin-like domain of whole MMP-2, greatly in hibits the cleavage process, demonstrating that MMP-2 interacts with collagen type IV preferentially through its fibronectin-like domain. Conversely, the removal of the hemopexin-like domain, using only the catalytic domain of MMP-2, has only a limited effect on the catalytic efficiency toward collagen IV, indicating that the missing domain does not have great relevance for the overall mechanism. Finally, we have investigated the effect of MMP-2 proteolytic activity ex vivo. MMP-2 action negatively affects the neutrophils' migration across type IV coated membranes and this is likely related to the production of lower molecular weight fragments that impair the cellular migration.
235-I * A NEW PRESSURE MAPPING SYSTEM TOWARDS OPTIMISING CARDIAC PROSTHETIC ATTACHMENT (2014)

Objectives: A digital pressure mapping system based on thin film transducers is introduced to precisely quantify compression forces between sutured cardiac valve prosthetics and underlying annular tissue. This technology was developed to explore technical factors affecting the pressures generated in simulated and tissue heart models.
Erdalkalimetalle als Gastionen in der Polyoxopalladatchemie: vom Nanowürfel über eine offenschalige Struktur zum Nanostern (2014)

Abstract Die drei neuartigen, diskreten Palladium(II)‐Oxocluster [CaPd 12 O 8 (PhAsO 3 ) 8 ] 6− ( CaPd 12 ), [SrPd 12 O 6 (OH) 3 (PhAsO 3 ) 6 (OAc) 3 ] 4− ( SrPd 12 ) und [BaPd 15 O 10 (PhAsO 3 ) 10 ] 8− ( BaPd 15 ), bei denen die Erdalkalimetallionen im Innern einer kapselförmigen Struktur vorliegen, wurden hergestellt und mit verschiedenen physikochemischen Methoden in Lösung und im Festkörper charakterisiert. Die Ergebnisse offenbaren einen strukturdirigierenden Templateffekt des jeweiligen Alkalimetallions, dessen Größe die Anordnung der Pd II ‐Oxo‐Schale bestimmt. Von besonderer Bedeutung ist der präzedenzlose Cluster SrPd 12 , der eine offenschalige Struktur aufweist und eine Strategie für den gezielten Entwurf von neuen Klassen von Polyoxoedelmetallaten aufzeigt. Der ungewöhnliche Acetat‐Wasser‐Ligandenaustausch in SrPd 12 macht diesen Cluster ferner zu einem vielversprechenden Kandidaten für die Edelmetall‐basierte Katalyse.
Recent Trends in Fructooligosaccharides Production (2009)

Prebiotics are food ingredients that promote host health beneficially due to their effect over the growth and activity of probiotic bacterial species. Prebiotic properties have been demonstrated for inulin-type fructans, galactoolicosaccharides and lactulose. Fructooligosaccharides (FOS), considered as inulin-type fructans, represent an important source of prebiotic compounds that are widely used as an ingredient in functional foods. FOS are produced by the action of fructosyltransferase from many plants, fungi and bacteria, and they are mainly composed of 1-kestose, nystose, and 1-beta-fructofuranosyl nystose. Among them, 1-kestose has better therapeutic properties than those with a high polymeric degree (GF(n > 4)). FOS exhibited properties than those with a high polymeric degree (GF(n>4)). FOS exhibited properties such as low caloric values, non-cariogenic properties, decrease levels of lipids and cholesterol, help gut absorption of ions, and stimulate the bifidobacteria growth in the human colon. This review presents a summary of the patents related with FOS production by industrial sucrose biotransformation or the use of recombinant fructosyltransferase enzymes. Also, a brief description of recent FOS applications will be discussed.
High Prevalence of Peripheral Arterial Disease in HIV-Infected Persons (2008)

The prevalence of symptomatic and asymptomatic PAD is high in the HIV-infected population and is much higher than expected (prevalence in the general population, approximately 3% at 60 years). This study suggests the presence of an epidemic of PAD approximately 20 years earlier in the HIV-infected than in the general population. Larger epidemiological studies are needed to better define risk factors and to evaluate whether PAD is associated with increased mortality, as it is in the general population.
The Tethered Aminohydroxylation (TA) of Cyclic Allylic Carbamates (2002)

The tethered aminohydroxylation of cyclic allylic carbamates is described using catalytic amounts of potassium osmate. The mechanism of reaction involves formation of an imido-osmium complex which adds intramolecularly to alkenes with complete control of both regio- and stereoselectivity: the formation of syn-aminodiol motifs is now straightforward using this chemistry. Proof of the mechanism was obtained with an X-ray crystal structure of an azaglycolate osmate ester intermediate.
Polylog randomized wait-free consensus (1996)

I present the first randomized wait-free implementation of consensus from multiple writer zmltiple reader register in which each process takes polylog (0(log2 n)) expected steps. To achieve this result, I assume a non-standard type of adversary (from [Abr88]). I argue that this type of adversary (which is more powerful than the oblivious adversary, but weaker than the strong adversary) is powerful enough to model practical systems. been extensively studied. With this model, processes communicate with each other through the use of shared objects. Examples of shared object types include data structures such as read/write register, queue, and set, and synchronization primitives such as test&set, fetch&add, and compare&swap. Even though different processes may concurrently access a shared object, it is desirable that the object behave as if all these accesses occur in some sequential order. More precisely, the behavior of a shared object must be keaTizab/e [H W90].
DAPSONE IN RHEUMATOID ARTHRITIS (1976)

After a preliminary period of observation, 71 patients with consistently active rheumatoid arthritis (RA) were given dapsone 50 mg daily for one week, then 100 mg daily. There was a significant improvement in subjective clinical state and there were significant falls in serum C-reactive protein (CRP) and the ESR; the Rose-Waaler titre (RW) did not fall. The results were compared with those in 78 patients who had gold. Subjective clinical improvement was slower with gold, but from six weeks the pattern of changes in clinical score, CRP and ESR was similar for both drugs. The RW fell during gold treatment. The results suggest dapsone is effective in RA; over-all it appears to be slightly less effective than gold but much less toxic.
The Axial Laminar Flow of Yield-Pseudoplastic Fluids in a Concentric Annulus (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Axial Laminar Flow of Yield-Pseudoplastic Fluids in a Concentric AnnulusRichard W. HanksCite this: Ind. Eng. Chem. Process Des. Dev. 1979, 18, 3, 488–493Publication Date (Print):July 1, 1979Publication History Published online1 May 2002Published inissue 1 July 1979https://pubs.acs.org/doi/10.1021/i260071a024https://doi.org/10.1021/i260071a024research-articleACS PublicationsRequest reuse permissionsArticle Views409Altmetric-Citations58LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
A Mobile Sensing Approach for Regional Surveillance of Fugitive Methane Emissions in Oil and Gas Production (2016)

This paper addresses the need for surveillance of fugitive methane emissions over broad geographical regions. Most existing techniques suffer from being either extensive (but qualitative) or quantitative (but intensive with poor scalability). A total of two novel advancements are made here. First, a recursive Bayesian method is presented for probabilistically characterizing fugitive point-sources from mobile sensor data. This approach is made possible by a new cross-plume integrated dispersion formulation that overcomes much of the need for time-averaging concentration data. The method is tested here against a limited data set of controlled methane release and shown to perform well. We then present an information-theoretic approach to plan the paths of the sensor-equipped vehicle, where the path is chosen so as to maximize expected reduction in integrated target source rate uncertainty in the region, subject to given starting and ending positions and prevailing meteorological conditions. The information-driven sensor path planning algorithm is tested and shown to provide robust results across a wide range of conditions. An overall system concept is presented for optionally piggybacking of these techniques onto normal industry maintenance operations using sensor-equipped work trucks.
An Automated High-Content Assay for Tumor Cell Migration through 3-Dimensional Matrices (2010)

High-content tumor cell migration assays in 3-dimensional (3D) extracellular matrix are a powerful tool for modeling and understanding the biology of this critical step in the process of metastasis. Currently available methods offer very limited throughput and are not amenable to studies of comparative pharmacology or small-scale screening. The authors present an automated approach to high-content tumor cell migration assays. A standard screening-sized plate with an array of microchannels was designed and constructed from common thermoplastics. After filling the channels with 3D matrix, cells were placed at one end of the channel, and migration into the channel was monitored via an imaging system. All liquid-handling steps were performed by standard liquid-handling robotics. Tumor cell migration in the channel was truly 3D and correlated with metastatic potential. The information-rich data from these assays were used to rank the potency of compounds inhibiting migration through 3D collagen as well as to gain additional insights into the compounds' activities related to cell health. This approach is compatible with a variety of multiparametric, morphological, and/or kinetic readouts.
Anaphylaxis avoidance and management: educating patients and their caregivers (2014)

Anaphylaxis is an increasingly prevalent problem in westernized countries. Therefore, it is of utmost importance that the increasing numbers of patients at risk for anaphylaxis receive proper education on the etiology and risk factors as well as appropriate treatment of anaphylaxis with epinephrine. The physician's role is crucial in order to educate the patients and care takers on effective measures to prevent anaphylaxis and empower them to take charge of early recognition and proper management of an anaphylactic reaction to prevent poor outcomes. This review summarizes the clinical presentation, triggers, avoidance, and management of anaphylaxis.