gebhart/patrepeval huggingface dataset:
Third component of human complement: structural requirements for its function (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThird component of human complement: structural requirements for its functionJarmila Janatova, Brian F. Tack, and James W. PrahlCite this: Biochemistry 1980, 19, 19, 4479–4485Publication Date (Print):September 16, 1980Publication History Published online1 May 2002Published inissue 16 September 1980https://pubs.acs.org/doi/10.1021/bi00560a015https://doi.org/10.1021/bi00560a015research-articleACS PublicationsRequest reuse permissionsArticle Views67Altmetric-Citations112LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Effectiveness of Positron Emission Tomography for the Detection of Melanoma Metastases (1998)

PET scanning is extremely sensitive (94.2%) and very specific (83.3%) for identifying metastatic melanoma, particularly in soft tissues, lymph nodes, and the liver. A number of second primary or metastatic tumors and an inflammatory response can also be localized by PET. This observation mandates a close clinical correlation with positive PET and emphasizes the importance of establishing a tissue diagnosis. False-negative scans in the presence of metastases are rare (4% of scans). Metastases < or =5 mm in diameter may not image well. PET is superior to CT in detecting melanoma metastases and has a role as a primary strategy in the staging of melanoma.
ChemInform Abstract: Thiazole as a Carbonyl Bioisostere. A Novel Class of Highly Potent and Selective 5‐HT3 Receptor Antagonists. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
FUNDAMENTALS OF SOIL BEHAVIOR (1976)

The book is intended to develop an understanding of the factors determining and controlling the engineering properties of soil, the factors controlling their magnitude, and the influences of environment and time. The two-part book contains the following chapters: Part 1 - the nature of soils; bonding, crystal structure and surface characteristics; soil mineralogy; soil formation and soil deposits; determination of soil composition; soil water; clay-water-electrolyte system; soil fabric and its measurement; Part 2 - soil behavior; soil composition and engineering properties; effective, intergranular and total stress; soil structure and its stability; fabric, structure and property relationships, volume change behavior; strength and deformation behavior; and, conduction phenomena. /TRRL/
Differences between IL-4- and IL-4 receptor alpha-deficient mice in chronic leishmaniasis reveal a protective role for IL-13 receptor signaling. (1999)

IL-4 receptor alpha-chain-deficient (IL-4Ralpha-/-) mice were generated by homologous and site-specific recombination, using the Cre/loxP system in BALB/c-derived embryonic stem cells. In vitro analysis of cells from these mice revealed impaired IL-4- and IL-13-mediated functions, demonstrating that the IL-4Ralpha-chain is an essential component of both the IL-4 and the IL-13 receptor. Whereas Leishmania major-infected BALB/c mice developed fatal progressive disease with type 2 Ab responses within 3 mo, both IL-4Ralpha-/- and IL-4-/- BALB/c mice contained infection with reduced footpad swelling, parasite load, moderate histopathology, and type 1 Ab responses during this time period. Conclusively, these results demonstrate an IL-4-dependent mechanism of susceptibility in BALB/c mice. Nevertheless, in contrast to mutant mice, infected C57BL/6 mice healed completely within 3 mo, indicating that additional factors are necessary for subsequent healing and elimination of the pathogen. During the further course of infection, IL-4Ralpha-/- mice developed progressive disease with massive footpad swelling. Lesions became ulcerative and necrotic with subsequent destruction of connective tissue and bones, as well as dissemination into organs and consequent mortality within the monitored 6 mo of chronic infection. In striking contrast, IL-4-/- mice maintained control of infection on a moderate level, but were unable to clear the pathogen. The distinct phenotypes of the BALB/c embryonic stem cell-derived IL-4-/- and IL-4Ralpha-/- mouse strains identify previously unsuspected mechanisms for maintaining host immunity to chronic infection with L. major, mediated by a functional IL-13 receptor.
Use of Reflectance Confocal Microscopy to Monitor Response of Lentigo Maligna to Nonsurgical Treatment (2009)

Log in or Register Subscribe to journalSubscribe Get new issue alertsGet alerts Enter your Email address: Wolters Kluwer Health may email you for journal alerts and information, but is committed to maintaining your privacy and will not share your personal information without your express consent. For more information, please refer to our Privacy Policy. Subscribe to eTOC Secondary Logo Journal Logo All Articles Images Videos Podcasts Blogs Advanced Search Toggle navigation Subscribe Register Login Articles & Issues Current IssuePrevious IssuesPublished Ahead-of-PrintSpecial Issues Collections Advancement FlapCartilage GraphCompsite GraphEar ReconstructionEyelid ReconstructionFull Thickness Skin GraphInterpolation FlapLip ReconstructionNasal ALANasal ReconstructionNasal Tip - SidewallPull Through FlapRotation FlapSkin Cancer AwarenessSoft TriangleTransposistion Flap VideosPodcastFor Authors Submit a ManuscriptInformation for AuthorsLanguage Editing ServicesAuthor Permissions Journal Info About the JournalEditorial BoardAbout the societyAdvertisingSubscription ServicesReprintsOpen AccessRights and PermissionsNZSCM Member Info All Articles Images Videos Podcasts Blogs Advanced Search
Fundamental Factors Affecting Upper-Room Ultraviolet Germicidal Irradiation—Part I. Experimental (2007)

The objective of this research was to study the factors that relate to the effectiveness of upper-room ultraviolet germicidal irradiation for inactivating airborne microorganisms. The work was conducted in a room-sized chamber designed and furnished for investigations of this nature. Nebulized Serratia marcescens, Bacillus subtilis spores, and vaccinia virus were used as test aerosols. Most data were collected from steady-state experiments comparing the number of viable organisms in the chamber air remaining with UV lamps turned on to the number with UV lamps turned off, but some decay experiments were conducted to compare the two methods. UV power level had a strong influence but was fully effective only in the presence of air mixing that produced vigorous vertical air currents. A conclusion of the study is that an upper-room ultraviolet installation is a complex system that requires careful integration of UV luminaires, UV power, and room ventilation arrangements.
Organylcyanosilane. I. Zur Darstellung von Methyl‐ und Methyl‐dialkylamino‐cyanosilanen (1966)

Organylcyanosilane wurden erhalten durch Umsetzung von . Organylchlorsilan, Organylsilylamin und Blausäure, . Organyljodsilan, tert. Amin und Blausäure bzw. Jodcyan, . tert. Organylsilylamin und Jodcyan, . Organyl-dialkylamino-chlorsilan und Trimethylcyanosilan. Als Produkte der Reaktionen gemäß 2., 3. und 4. konnten u. a. Dimethyl-dialkylamino-cyanosilane (CH3)2Si(NR2)CN (R = CH3, C2H5) isoliert werden. Organocyanosilanes can be prepared by the interactions between . organochlorosilane, organosilylamine and hydrocyanic acid; . organoiodosilane, tertiary amine and hydrocyanic acid or cyanogen iodide; . tertiary organosilylanine and cyanogen iodide; . organodialkylaminochlorosilane and trimethylcyanosilane. Dimethyl-dialkylamino-cyanosilanes, (CH3)2Si(NR2)CN (R = CH3, C2H5), were be isolated from the reactions 2., 3. and 4.
POU family transcription factors in sensory neurons (1992)

Conference Article| August 01 1992 POU family transcription factors in sensory neurons D. S. Latchman; D. S. Latchman 1Medical Molecular Biology Unit, Department of Biochemistry, Division of Molecular Pathology, University College and Middlesex School of Medicine, The Windeyer Building, Cleveland Street, London W1P 6DB Search for other works by this author on: This Site PubMed Google Scholar C. L. Dent; C. L. Dent 1Medical Molecular Biology Unit, Department of Biochemistry, Division of Molecular Pathology, University College and Middlesex School of Medicine, The Windeyer Building, Cleveland Street, London W1P 6DB Search for other works by this author on: This Site PubMed Google Scholar K. A. Lillycrop; K. A. Lillycrop 1Medical Molecular Biology Unit, Department of Biochemistry, Division of Molecular Pathology, University College and Middlesex School of Medicine, The Windeyer Building, Cleveland Street, London W1P 6DB Search for other works by this author on: This Site PubMed Google Scholar J. N. Wood J. N. Wood *Sandoz Institute for Medical Research, 5 Gower Place, London WC1E 6BN, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1992) 20 (3): 627–631. https://doi.org/10.1042/bst0200627 Article history Received: April 16 1992 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation D. S. Latchman, C. L. Dent, K. A. Lillycrop, J. N. Wood; POU family transcription factors in sensory neurons. Biochem Soc Trans 1 August 1992; 20 (3): 627–631. doi: https://doi.org/10.1042/bst0200627 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: DRG, dorsal root ganglia, HSV, herpes simplex virus, NGF, nerve growth factor, PCR, polymerase chain reaction, POU, Pit-Oct-Unc domain This content is only available as a PDF. © 1992 Biochemical Society1992 Article PDF first page preview Close Modal You do not currently have access to this content.
Isolation and Expansion of Endothelial Progenitor Cells Derived from Mouse Embryonic Stem Cells (2012)

The unlimited differentiation and proliferation capacity of embryonic stem cells represents a great resource for regenerative medicine. Here, we describe a method for differentiating, isolating, and expanding endothelial cells (ECs) from mouse embryonic stem cells (mESCs). First, mESCs are expanded on a mouse embryonic fibroblast (mEF) feeder layer and partially differentiated into embryoid bodies (EBs) by growing the cells in an ultra-low attachment plate for up to 5 days. The EBs are then differentiated along the endothelial lineage using endothelial growth medium supplemented with 40 ng/mL vascular endothelial growth factor (VEGF). The differentiated endothelial population expresses both Fetal Liver Kinase 1 (Flk-1) and VE-Cadherin on the cell surface which can be further purified using a fluorescence-activated cell sorting (FACS) system and subsequently expanded on 0.1 % gelatin-coated plates. The differentiated cells can be analyzed by real-time PCR and flow cytometry to confirm enrichment of EC-specific genes and proteins.
Simultaneous expression of immunoglobulin mu and delta heavy chains by a cloned B-cell lymphoma: a single copy of the VH gene is shared by two adjacent CH genes. (1982)

The cloned murine B-cell lymphoma line (BCL1) that expresses surface IgM and IgD is considered to be a model for the immunoglobulin gene expression of the mature virgin B cell. Of particular interest is the mechanism by which a single VH gene is shared by two CH genes. We examined the organization of the immunoglobulin heavy chain genes in BCL1 DNA. A single arrangement of CH genes was found with the expressed VHDJH gene complex just 5' to the Cmu gene. The complete DNA sequence of the VH gene was determined. No rearrangement occurred in the intervening DNA between the JH and C mu genes or between the C mu and C delta genes. We conclude that dual expression of mu and delta heavy chains using a single VH gene is accomplished by alternate processing of a primary transcript that encompasses the the VHDJH complex and both CH genes.
Exploiting the Vitamin B<sub>12</sub> Pathway To Enhance Oral Drug Delivery via Polymeric Micelles (2005)

Vitamin B12 (VB12)-modified dextran-g-polyethyleneoxide cetyl ether (DEX-g-PEO-C16) was synthesized by linking VB12 residues to a DEX-g-PEO-C16 copolymer via a 2,2'-(ethylenedioxy)bis(ethylamine) spacer. The level of VB12 substitution on the DEX-g-PEO-C16 copolymer reached 1.68% (w/w). In aqueous solution, DEX-based copolymers form micelles that can entrap within their hydrophobic core up to 8.5% w/w of cyclosporin A (CsA), a poorly water soluble immunosuppressant. The permeability of Caco-2 cell membranes to CsA incorporated in VB12 modified and unmodified polymeric micelles was monitored in the presence and absence of intrinsic factor (IF). The apical (AP) to basolateral (BL) permeation of CsA through Caco-2 cell monolayers after 24 h of transport was significantly higher (1.8 and 2.3 times in absence and presence of IF, respectively) in the case of CsA loaded in VB12-modified polymeric micelles, compared to CsA in unmodified micelles. The results point to possible improvement in the application of polysaccharide-based polymeric micelles as targeted polymeric drug carriers for the oral delivery of poorly water soluble drugs.
Effects of additives on the orientation and strength of plastic ferrite magnet (1989)

In the manufacture of injection-bonded magnets from Sr-ferrite powder with nylon-12 resin, coupling agents and lubricant are normally added to improve the mechanical properties and to decrease abrasion by the injection molding machine. The effects of these additives on the particle orientation, compressive strength, and rheological behavior are investigated. Two coupling agents (one belonging to the silane series, the other to the titanate series) plus one lubricant have been added to the ferrite powders. Experimental results show that the lubricant can increase alignment by 14% and decrease compressive strength by 42%. The silane coupling agent induces 5.7% and 50.9% enhancement of alignment and compressive strength, respectively, and is better than the titanate coupling agent. In general, the best composition is 1.0 wt.% coupling agent combined with 0.5 wt.% lubricant C, yielding 82.7% alignment and 15.2 kg/mm/sup 2/ compressive strength.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Damping effects in MEMS resonators (2012)

Damping effects are very important in MEMS-based sensors and actuators. In this paper we use analytical models and finite element (FE) computations to quantify the energy losses due to viscous fluid damping, acoustic radiation and thermo-elastic damping. To treat the case where squeeze/slide film models can not be applied, we have implemented in a commercial FE package a new incompressible flow solver based on a gauge formulation. We are thus able to solve for full flows around complex 3D geometries in the frequency domain and predict viscous damping of resonant MEMS structures. The full methodology is exemplified on the response of a MEMS silicon resonator, including acoustic driving and piezoelectric sensing.
Single Sign-On Configuration and Troubleshooting for SAS® 9.2 Enterprise BI Web Applications (2011)

Single Sign-On (SSO) means different things for different configurations and applications. The Single Sign-On logic and process for SAS® 9.2 Enterprise BI Web applications are examined based on various enterprise-level Web infrastructure configurations in which SAS Web applications are deployed. With such deployments, troubleshooting configuration and authentication errors is confusing and time-consuming. This paper explains Single Sign-On in terms of initial source of authentication, security arrangement, and trust relationships among the Web components and how SAS Web applications manage and consume externally authenticated user identity. Then this paper explores the troubleshooting strategies available for each of the enterprise-level Web infrastructure configurations. A methodology, along with recommended solutions, is presented for common error messages.
Development of a 6 Power Roller Half-Toroidal CVT (2004)

A half-toroidal double cavity CVT with torque capacity of 340Nm was put into market in 1999. Following to this success, a new project of transmitting higher torque by smaller size has been started. The design goal is set up to develop a 430Nm CVT with 6 power rollers instead of conventional 4 power rollers. On the design of the CVT, equal torque transmission among 6 power rollers and stability of speed ratio control mechanism are important issues. This paper describes the synchronizing mechanism of the 6 power rollers CVT, and the measurement of power rollers motion and efficiency.
Las encíclicas "Rerum Novarum" y "Quadragesimo Anno" ante la realidad hispanoamericana (1951)

(En conmemoración del sexagésimo aniversario de la Encíclica "Rerurn Novarum" y del vigésimo de la Encíclica "Quadragesimo Anno": 15 de mayo de 1891 - 15 de mayo de 1931).Este ensayo constituye un resumen de algunas ideas del amplio trabajo, titulado "La Justicia social en el orden cristiano de la sociedad'', del mismo autor, trabajo que fue apreciado con el primer premio del Gran Concurso de Trabajos científicos sociales, organizado por la Acción Católica Argentina en ocasión del cincuentenario de la Encíclica “Rerum Novarum" y del décimo aniversario de la Encíclica “Quadragesimo anno" (1941).
REGIOSELECTIVE POLYPRENYL REARRANGEMENT OF POLYPRENYL 2,3,4,5-TETRASUBSTITUTED PHENYL ETHERS PROMOTED BY BORON TRIFLUORIDE (1982)

Abstract 4-Acetoxy-6-polyprenyl-2,3,5-trimethylphenols or 2,3-dimethoxy-5-methyl-6-polyprenylhydroquinones were obtained selectively by the BF3·OEt2 catalyzed polyprenyl rearrangement of polyprenyl 4-acetoxy-2,3,5-trimethylphenyl ethers or polyprenyl 2,3-dimethoxy-4-hydroxy-5-methylphenyl ethers.
Optical characterization of process-dependent charging in hafnium oxide structures (2006)

We present a comprehensive study of Si∕SiO2∕Hf(1−x)SixO2 structures using optical second-harmonic generation (SHG), supported by spectroscopic ellipsometry, photoelectron spectroscopy, and noncontact electrical measurements. Rotationally anisotropic and spectroscopic SHG depend strongly on dielectric composition and on postdeposition annealing in NH3. Spectroscopic SHG shows that these variations are linked to variations in charge trapped in the high-κ material, which influences SHG via electrostatic-field-induced SH (EFISH) generation. Supporting measurements corroborate this interpretation. Noncontact electrical measurements and x-ray photoelectron spectroscopy show annealing-dependent trends in interface charge and nitrogen incorporation, respectively, that mirror annealing-dependent trends in EFISH generation. The results show that SHG can potentially be used as an in situ, real-time monitor of internal electric fields attributable to composition- and annealing-dependent fixed charge in the oxide layers.
Genetic Requirements of Phage λ Red-Mediated Gene Replacement in <i>Escherichia coli</i> K-12 (2000)

Recombination between short linear double-stranded DNA molecules and Escherichia coli chromosomes bearing the red genes of bacteriophage lambda in place of recBCD was tested in strains bearing mutations in genes known to affect recombination in other cellular pathways. The linear DNA was a 4-kb fragment containing the cat gene, with flanking lac sequences, released from an infecting phage chromosome by restriction enzyme cleavage in the cell; formation of Lac(-) chloramphenicol-resistant bacterial progeny was measured. Recombinant formation was found to be reduced in ruvAB and recQ strains. In this genetic background, mutations in recF, recO, and recR had large effects on both cell viability and on recombination. In these cases, deletion of the sulA gene improved viability and strain stability, without improving recombination ability. Expression of a gene(s) from the nin region of phage lambda partially complemented both the viability and recombination defects of the recF, recO, and recR mutants and the recombination defect of ruvC but not of ruvAB or recQ mutants.
Practical Tools for Vehicle Impact Simulation Part 2: An Integrated Approach Using Oasys Dyna3D (1991)

This paper describes the use of a non-linear finite element analysis program (OASYS DYNA3D) for the simulation of vehicle impact events. The purpose of the paper is to demonstrate how one single program can be used at a number of different levels of complexity to serve the needs of the analyst at all stages of vehicle design. Examples are given of lumped mass/spring simulations, continuum (shell/brick) simulations and an intermediate stage in which the two analytical philosophies are combined to form a ‘hybrid’ approach. The paper conclues with some observations on the future for hybrid modelling techniques and suggests some simple extensions which would allow the occupant and safety restraint systems to be included in the global vehicle simulation.
ChemInform Abstract: Evaluated Material Properties for a Sintered α‐Alumina (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
‘Simoneʼs OncOpinion’ on ‘The Frustratingly Slow Pace of Quality Improvement in Cancer Care’ (1/25/06 Issue) (2006)

I think all physicians including me want to improve the quality of our medical care. What I don't want are committees and bureaucracies interfering with my professional judgment and decisions. Because of this fierce independence and need for autonomy, which I think is shared by most physicians, I am a passionate opponent of “Quality Performance Measurement,” “Pay for Performance,” etc., all of which imply that physicians should be conformists adhering to “guidelines” developed by bureaucracies rather than independent professionals practicing the art of medicine. I have yet to see even one “Quality Improvement” activity that I have not regarded as a paper-pushing bureaucratic waste of my time. Walter Wood, MD San Jose, CA