gebhart/patrepeval huggingface dataset:
Real-Time Structural Analysis of Compositionally Graded InGaAs/GaAs(0 0 1) Layers (2011)

Compositionally step-graded InGaAs/GaAs(0 0 1) buffers with overshooting (OS) layers were evaluated by several characterization techniques for higher efficiency metamorphic III-V multijunction solar cells. By high-resolution X-ray diffraction, we found that fully relaxed or tensile strained top layers can be obtained by choosing appropriate OS layer thickness. Moreover, from real-time structural analysis using in situ X-ray reciprocal space mapping (in situ RSM), it was proved that the top layer is almost strained to the OS layers, and it is independent of the thicknesses of the OS layers. Dislocations in the vicinity of the OS layers were observed by transmission electron microscopy, and the validity of results of in situ RSM was confirmed from the viewpoint of misfit dislocation behavior. Finally, by photoluminescence measurements, we showed that tensile strained top layers may be suitable for the improvement of minority-carrier lifetime.
Deep Learning for Super-Resolution Channel Estimation and DOA Estimation Based Massive MIMO System (2018)

The recent concept of massive multiple-input multiple-output (MIMO) can significantly improve the capacity of the communication network, and it has been regarded as a promising technology for the next-generation wireless communications. However, the fundamental challenge of existing massive MIMO systems is that high computational complexity and complicated spatial structures bring great difficulties to exploit the characteristics of the channel and sparsity of these multi-antennas systems. To address this problem, in this paper, we focus on channel estimation and direction-of-arrival (DOA) estimation, and a novel framework that integrates the massive MIMO into deep learning is proposed. To realize end-to-end performance, a deep neural network (DNN) is employed to conduct offline learning and online learning procedures, which is effective to learn the statistics of the wireless channel and the spatial structures in the angle domain. Concretely, the DNN is first trained by simulated data in different channel conditions with the aids of the offline learning, and then corresponding output data can be obtained based on current input data during online learning process. In order to realize super-resolution channel estimation and DOA estimation, two algorithms based on the deep learning are developed, in which the DOA can be estimated in the angle domain without additional complexity directly. Furthermore, simulation results corroborate that the proposed deep learning based scheme can achieve better performance in terms of the DOA estimation and the channel estimation compared with conventional methods, and the proposed scheme is well investigated by extensive simulation in various cases for testing its robustness.
D<sub>1</sub> and D<sub>2</sub> Dopaminergic Regulation of Acetylcholine Release from Striata of Freely Moving Rats (1990)

The effects of selective D1 and D2 dopaminergic agents on the extracellular acetylcholine (ACh) content in striata of freely moving rats were determined by the microdialysis technique. LY 171555, a selective D2 agonist, reduced ACh output by approximately 30% within 20 min at the dose of 0.2 mg/kg, i.p., whereas the D2 antagonists (-)-remoxipride (10 mg/kg, s.c.) and L-sulpiride (50 mg/kg, i.p.) induced maximal increases of approximately 50% within 10 and 20 min, respectively. In contrast, the D1 antagonist SCH 23390 (0.25 mg/kg, s.c.) decreased the extracellular ACh content by approximately 30% in 20 min, but lower doses--0.025 and 0.05 mg/kg--had no such effect. The stimulation of ACh release by LY 171555 was prevented by (-)-remoxipride but not by SCH 23390 (0.25 mg/kg, s.c.). In addition, the D1 agonist SKF 38393 failed to modify the ACh increasing effect of (-)-remoxipride. Thus, the D1 and D2 receptors subserve opposing functions on ACh release. The D1/D2 dopaminergic agonist R-apomorphine, at the does of 1 mg/kg, i.p., reduced ACh output by approximately 35% only when D1 receptors were blocked by SCH 23390 (0.025 mg/kg, s.c.). The results provide clear in vivo evidence of the tonic inhibition exerted by dopaminergic nigrostriatal input on the cholinergic system of the basal ganglia through D1 and D2 receptors.
An Abandoned Object Detection System Based on Dual Background and Motion Analysis (2012)

In this paper, a video-surveillance system for the detection of abandoned objects and its owner is proposed. The approach is based on dual background for the detection of static foreground and motion analysis for its owner. The static foreground detection performs in two steps: constructing and updating a pixel-based dual background to obtain the dual foreground, carrying a register for the evidence frame to give an alarm. Motion analysis establishes the correspondence of foreground objects between the successive frames using color histogram, in order to label the objects and record their characteristic and state. When the static foreground detection part find a possible target, the result of the motion analysis can be used to estimate the owner. We demonstrate that this abandoned object detection system solves successfully a high percentage of occlusions.
Structure–activity relationships for epidermal ornithine decarboxylase induction and skin tumor promotion by anthrones (1988)

The present study was designed to compare the skin tumor promoting and epidermal ornithine decarboxylase (ODC) inducing activities of various structural analogs of anthralin (1,8-dihydroxy-9-anthrone) and chrysarobin (1,8-dihydroxy-3-methyl-9-anthrone). Groups of 30 SENCAR mice each were initiated with 7,12-dimethylbenz[a]anthracene and 2 weeks later promoted with once- or twice-weekly applications of various doses of these anthrone derivatives. Carbon-10 (C10)-acyl derivatives of anthralin were active skin tumor promoters in the range of 25-440 nmol per mouse. 10-Acetylanthralin was significantly more active than 10-myristoyl-anthralin at low doses (e.g. 25 and 50 nmol per mouse) and nearly as potent as the unsubstituted compound. Higher doses (greater than or equal to 100 nmol per mouse) of this derivative were toxic, hence, reducing the final papilloma response. On a relative activity scale where anthralin is 1.0, these derivatives had activities that were approximately 0.7 and 0.2, respectively. 10,10-Dipropylanthralin was totally inactive at the doses tested. C6-Substituted derivatives of chrysarobin demonstrated diverse tumor promoting activities when tested in the range of 25-440 nmol per mouse. On a relative activity scale where chrysarobin is 1.0, 6-methoxychrysarobin (physcion anthrone) was approximately 0.9, whereas 6-hydroxychrysarobin (emodin anthrone) had no activity. Chrysophanic acid (1,8-dihydroxy-3-methyl-9,10-anthraquinone) was also inactive as a tumor promoter at the doses tested. In general, the tumor promoting activities of these anthrone derivatives correlated very well with their ability to induce epidermal ODC after a single topical application indicating an important role for this enzyme in skin tumor promotion by anthones. The ability of C10-substituted derivatives of anthralin to undergo base catalyzed oxidation in vitro correlated with both ODC inducing and tumor promoting activities. In addition, copper(II)bis(diisopropylsalicylate) was found to inhibit both ODC induction and skin tumor promotion by chrysarobin. These latter data, when taken together, suggest a role for oxidation at C10 in skin tumor promotion by anthrone derivatives.
Synthesis of Perfluoroalkyl Siloxane with C˭C and C‒C Bridged Groups Through Single Electron Transfer Reaction (2014)

AbstractThe sodium dithionite–initiated reaction of perfluoroalkyl iodides with vinylsiloxane in an acetonitrile–water mixture efficiently proceeded under mild conditions. As a result, the perfluoroalkyl groups were bonded onto C˭C on the end-position or side-chain of the siloxane. The subsequent elimination or reduction of the C‒I bridged groups produced the corresponding RfCH˭CH‒ or RfCH2CH2− substituted group on siloxane. All fluorosiloxanes were characterized by FT-IR, 1H NMR, 19F NMR, and EI-MS. The morphology and microstructures of the fluorosiloxane films were further observed by atomic force microscopy and X-ray photoelectron microscope.Keywords: Perfluoroalkyl siloxanesingle electron transferbridged groupsfilm morphology research
Anomalous dispersion in a solid, silica-based fiber (2006)

We demonstrate an all-solid (nonholey), silica-based fiber with anomalous dispersion at wavelengths where silica material dispersion is negative. This is achieved by exploiting the enhanced dispersion engineering capabilities of higher-order modes in a fiber, yielding + 60 ps/nm km dispersion at 1080 nm. By coupling to the desired higher-order mode with low-loss in-fiber gratings, we realize a 5 m long fiber module with a 300 fs/nm dispersion that yields a 1 dB bandwidth of 51 nm with an insertion loss of approximately 0.1 dB at the center wavelength of 1080 nm. We demonstrate its functionality as a critical enabler for an all-fiber, Yb-based, mode-locked femtosecond ring laser.
The morphology of intracellularly labeled rat subthalamic neurons: A light microscopic analysis (1983)

Light microscopic analysis of rat subthalamic (STH) neurons which were intracellularly labeled with horseradish peroxidase, following the acquisition of electrophysiological data, revealed the following: (1) The somata of STH neurons were polygonal or oval with occasionally a few somatic spines. Usually three or four primary dendrites arose from the soma. Dendritic trunks tapered slightly and divided into long, thin, sparsely spined branches. Dendrites of some STH neurons extended into the cerebral peduncle. (2) Reconstruction of the dendritic field was made in three different planes. In either sagittal or frontal planes, the dendritic field was usually oval and the long axis was parallel to the main axis of STH. In the horizontal plane, the dendritic field of all neurons was polygonal. (3) The axons of all the neurons analyzed originated from the soma and were traced beyond the borders of STH, thus indicating that they were projection neurons. All the parent axons bifurcated at least once. After bifurcation, one axon branch coursed dorsolaterally within the cerebral peduncle and terminated in the globus pallidus. The other branch coursed caudally or mediocaudally and arborized in the substantia nigra. Frequently, the axon branches projecting toward the globus pallidus emitted fine axon collaterals within the entopeduncular nucleus. (4) About one-half of the analyzed STH neurons had intranuclear axon collaterals. The neurons with intranuclear collaterals had a higher dendritic tips/stems ratio than neurons without intranuclear collaterals. This observation indicated that STH neurons could be divided into two groups according to their axonal morphology. (5) The axonal terminal arborization observed in all the target sites (i.e., globus pallidus, entopeduncular nucleus, STH, and substantia nigra) were formed with varicose collateral branches which also gave rise to short filaments with beaded endings. Some of these projection neurons could therefore communicate with the target neurons in the globus pallidus, substantia nigra, entopeduncular nucleus, as well as STH through their collateral system.
Line-by-line pulse shaping with spectral resolution below 890 MHz (2012)

Line-by-line pulse shaping is demonstrated on a 890 MHz repetition rate mode-locked titanium sapphire laser. The high resolution pulse shaper is based on a virtual imaged phased array (VIPA) with a free spectral range of 25 GHz. For our implementation, the mask repeats every VIPA free spectral range, which corresponds to every 28 comb lines. Individual frequency modes from the laser are also resolved using the same VIPA paired with a diffraction grating to achieve a resolution of 357 MHz. Several output waveforms are compared with simulation to understand differences with the ideal case.
Manipulation of redox signaling in mammalian cells enabled by controlled photogeneration of reactive oxygen species (2005)

Reactive oxygen species (ROS) comprise a group of noxious byproducts of oxidative processes which participate in the induction of many common diseases. However, understanding their role in the regulation of normal physiological redox signaling is currently evolving. Detailed study of the dynamic functions of ROS within the biological milieu is difficult because of their high chemical reactivity, short lifetime, minute concentrations and cytotoxicity at high concentrations. In this study, we show that increasing intracellular ROS levels, set off by controlled in situ photogeneration of a nontoxic bacteriochlorophyll-based sensitizer initiate responses in cultured melanoma cells. Using hydroethidine as detector, we determined light-dependent generation of superoxide and hydroxyl radicals in cell-free and cell culture models. Monitoring the ROS-induced responses revealed individual and differential behavior of protein kinases [p38, mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK) and Akt] as well as effects on the subcellular distribution of phosphorylated p38. Furthermore, alterations in morphology and motility and effects on cell viability as a function of time and photosensitizer doses were observed. Following mild ROS challenge, enzymatic and cellular changes were observed in the majority of the cells, without inducing extensive cell death. However, upon vigorous ROS challenge, a similar profile of the overall responses was observed, terminating in cell death. This study shows that precisely controlled photogeneration of ROS can provide simple, fine-tuned, noninvasive manipulation of ROS-sensitive cellular responses ranging from individual enzymes to gross behavior of target cells. The observations made with this tool enable a dynamic and causal correlation, presenting a new alternative for studying the role of ROS in cellular redox signaling.
Salivary levels of immunoglobulin A in Triathletes (1997)

We investigated whether the physical exercise of an olympic distance triathlon affected the salivary IgA excretion of triathletes, as a biomarker for mucosal immune defence. 42 triathletes participated in the study. It was found that the salivary flow rate was decreased significantly after the race, thereby resulting in a significant reduction of the total salivary IgA output. The salivary IgA concentration (mg IgA/ml) did not differ, but expressed as total salivary protein, a significant reduction was observed. This was on the account of the salivary protein concentration (mg protein/ml), which was significantly increased. In contrast to the IgA secretion, the salivary amylase activity was increased significantly after the race. Therefore, our data suggest that the exercise of a triathlon may decrease the level of IgA-mediated immune protection at the mucosal surface. As triathletes may during the race be exposed to micro-organisms present in the swimming water, a decreased IgA-mediated immunity during the race may pose triathletes at an increased risk of infections.
Nociceptors in Cardiovascular Functions: Complex Interplay as a Result of Cyclooxygenase Inhibition (2006)

Prostaglandins (PGs) are requisite components of inflammatory pain as indicated by the efficacy of cyclooxygenase 1/2 (COX1/2) inhibitors. PGs do not activate nociceptive ion channels directly, but sensitize them by downstream mechanisms linked to G-protein coupled receptors. Antiinflammatory effects are purported to arise from inhibition of synthesis and/or release of proinflammatory agents. Release of these agents from peripheral and central terminals of sensory neurons modulates nociceptive input from the periphery and synaptic transmission at the first sensory synapse, respectively. Heart and blood vessels are densely innervated by sensory nerve endings that express chemo-, mechano-, and thermo-sensitive receptors. Activation of these receptors mediates synthesis and/or release of vasoactive agents by virtue of their Ca2+permeability. In this article, we discuss that inhibition of COX2 reduces PG synthesis and renders beneficial effects by preventing sensitization of nociceptors, but at the same time, it might contribute to deleterious cardiovascular effects by compromising the synthesis and/or release of vasoactive agents.
Solubilization of Acyl‐CoA elongases from developing rapeseed (<i>Brassica napus</i> L.) (1993)

Abstract Acyl‐CoA elongases are important in producing high‐erucic acid rapeseed. The effects of Triton X‐100, N ‐octyl‐β‐D‐glucopyranoside and deoxycholate on the C18:1‐CoA and C20:1‐CoA elongase(s) have been studied by using a 15,000 × g pellet from developing rapeseed. The synthesis of very long chain monounsaturated fatty acids (VLCMFA) and, in particular, that of erucic acid were stimulated by Triton X‐100, whatever the substrate used. In the presence of N ‐octyl‐β‐D‐glucopyranoside, the elongase activity was practically unchanged, whereas deoxycholate strongly inhibited VLCMFA synthesis. Triton X‐100 was chosen for the solubilization, at an optimal Triton X‐100/protein (w/w) ratio of 2.5. Acyl‐CoAs were the major products synthesized by the solubilized acyl‐CoA elongase(s). The analysis of the reaction intermediates showed that the entire elongation complex has been solubilized and was still functional.
Detecting Perception of Smartphone Notifications Using Skin Conductance Responses (2019)

Today's smartphone notification systems are incapable of determining whether a notification has been successfully perceived without explicit interaction from the user. If the system incorrectly assumes that a notification has not been perceived, it may repeat it redundantly, disrupting the user and others (e.g., phone ringing). Or, if it incorrectly assumes that a notification was perceived, and therefore fails to repeat it, the notification will be missed altogether (e.g., text message). Results from a laboratory study confirm, for the first time, that both vibrotactile and auditory smartphone notifications induce skin conductance responses (SCR), that the induced responses differ from that of arbitrary stimuli, and that they could be employed to predict perception of smartphone notifications after their presentation using wearable sensors.
Design and Solution Structure of Functional Peptide Mimetics of Nerve Growth Factor (2000)

The C-D loop in nerve growth factor (NGF) is involved in binding to the NGF receptor, TrkA. It is flexible and adopts several different types conformations in different NGF crystal forms. We have previously shown that a small cyclic peptide derived from the C-D loop of NGF binds to the TrkA receptor by mimicking the structure of this loop. To understand structure-function relationships in NGF C-D loop mimetics, we have produced a series of peptides predicted to form different types of beta-turns. The peptides were tested for their ability to promote cell survival in serum-free medium and to induce TrkA tyrosine phosphorylation. NMR structural studies were used to determined the backbone conformation and the spatial orientation of side chains involved in binding to the TrkA receptor. Peptides that form type I or type gammaL-alphaR beta-turns were the most active. The variety of active loop conformations suggests that the mimetics (and NGF) accommodate the binding site on TrkA by an 'induced fit' mechanism. In agreement with this hypothesis, NMR relaxation measurements detected both fast and slow motion in the peptides. We also characterized a retro-inverso peptide derived from the NGF C-D loop. This D-amino acid cyclic peptide did not adopt a conformation homologous to the NGF C-D loop and was inactive. This may be representative of difficulties in producing structural and functional mimetics by retro-inverso schemes.
The allogeneic bisection of carrier-specific enhancement of monoclonal B-cell responses. (1975)

The ability of T cells to enhance the response of syngeneic and allogeneic B cells to thymus-dependent hapten-carrier conjugates was analyzed. This analysis was carried out on individual primary B cells in splenic fragment cultures derived from irradiated reconstituted mice. This system has several advantages: (a) the response of the B cells is entirely dependent on carrier priming of the irradiated recipient; (b) this B-cell response can be quantitated in terms of the number of responding cells; and (c) very small B-cell responses can be readily detected and analyzed. The results indicate that the majority of hapten-specific B cells were stimulated in allogeneic and syngeneic recipients only if these recipients were previously carrier primed. The number of B cells responding in carrier-primed allogeneic recipients was 60-70% of that in syngeneic carrier-primed recipients. The antibody-forming cell clones resulting from B cells stimulated in the allogeneic environment produced small amounts of antibody and antibody solely of the IgM immunoglobulin class, while the larger responses in syngeneic recipients were predominantly IgG1 or IgM plus IgG1. The capacity of collaborative interactions between carrier-primed T cells and primary B cells to yield IgG1 antibody-producing clones was shown to be dependent on syngeny between these cells in the H-2 gene complex. It is concluded that: (a) B cells can be triggered by T-dependent antigens to clone formation through collaboration with T cells which differ at the H-2 complex as long as these T cells recognize the antigen; (b) the immunoglobulin class produced by the progeny of stimulated B cells generally depends on the nature of the stimulatory event rather than the nature of the B cell itself; and (c) stimulation to IgG1 production is dependent on syngeny between the collaborating T and B cells probably within the Ir-1A region. The role of the Ia antigens in the formation of IgG1-producing clones is not yet clear; Ia identity could permit IgG1 production or, conversely, nonidentity of Ia could induce all allogeneic interactions which prohibit IgG1 production.
mTORC2 Activity Is Elevated in Gliomas and Promotes Growth and Cell Motility via Overexpression of Rictor (2007)

mTORC2 is a multimeric kinase composed of the mammalian target of rapamycin kinase (mTOR), mLST8, mSin1, and rictor. The complex is insensitive to acute rapamycin exposure and has shown functions in controlling cell growth and actin cytoskeletal assembly. mTORC2 has recently been shown to phosphorylate and activate Akt. Because approximately 70% of gliomas harbor high levels of activated Akt, we investigated whether mTORC2 activity was elevated in gliomas. In this study, we found that mTORC2 activity was elevated in glioma cell lines as well as in primary tumor cells as compared with normal brain tissue (P < 0.05). Moreover, we found that rictor protein and mRNA levels were also elevated and correlated with increased mTORC2 activity. Overexpression of rictor in cell lines led to increased mTORC2 assembly and activity. These lines exhibited increased anchorage-independent growth in soft agar, increased S-phase cell cycle distribution, increased motility, and elevated integrin beta(1) and beta(3) expression. In contrast, small interfering RNA-mediated knockdown of rictor inhibited these oncogenic activities. Protein kinase C alpha (PKC alpha) activity was shown to be elevated in rictor-overexpressing lines but reduced in rictor-knockdown clones, consistent with the known regulation of actin organization by mTORC2 via PKC alpha. Xenograft studies using these cell lines also supported a role for increased mTORC2 activity in tumorigenesis and enhanced tumor growth. In summary, these data suggest that mTORC2 is hyperactivated in gliomas and functions in promoting tumor cell proliferation and invasive potential due to increased complex formation as a result of the overexpression of rictor.