gebhart/patrepeval huggingface dataset:
Meniscus-assisted solution printing of large-grained perovskite films for high-efficiency solar cells (2017)

Control over morphology and crystallinity of metal halide perovskite films is of key importance to enable high-performance optoelectronics. However, this remains particularly challenging for solution-printed devices due to the complex crystallization kinetics of semiconductor materials within dynamic flow of inks. Here we report a simple yet effective meniscus-assisted solution printing (MASP) strategy to yield large-grained dense perovskite film with good crystallization and preferred orientation. Intriguingly, the outward convective flow triggered by fast solvent evaporation at the edge of the meniscus ink imparts the transport of perovskite solutes, thus facilitating the growth of micrometre-scale perovskite grains. The growth kinetics of perovskite crystals is scrutinized by in situ optical microscopy tracking to understand the crystallization mechanism. The perovskite films produced by MASP exhibit excellent optoelectronic properties with efficiencies approaching 20% in planar perovskite solar cells. This robust MASP strategy may in principle be easily extended to craft other solution-printed perovskite-based optoelectronics.
Regulation of human heme oxygenase-1 gene expression under thermal stress (1996)

Heme oxygenase-1 is an essential enzyme in heme catabolism, and its human gene promoter contains a putative heat shock element (HHO-HSE). This study was designed to analyze the regulation of human heme oxygenase-1 gene expression under thermal stress. The amounts of heme oxygenase-1 protein were not increased by heat shock (incubation at 42 degrees C) in human alveolar macrophages and in a human erythroblastic cell line, YN-1-0-A, whereas heat shock protein 70 (HSP70) was noticeably induced. However, heat shock factor does bind in vitro to HHO-HSE and the synthetic HHO-HSE by itself is sufficient to confer the increase in the transient expression of a reporter gene upon heat shock. The deletion of the sequence, located downstream from HHO-HSE, resulted in the activation of a reporter gene by heat shock. These results suggest that HHO-HSE is potentially functional but is repressed in vivo. Interestingly, heat shock abolished the remarkable increase in the levels of heme oxygenase-1 mRNA in YN-1-0-A cells treated with hemin or cadmium, in which HSP70 mRNA was noticeably induced. Furthermore, transient expression assays showed that heat shock inhibits the cadmium-mediated activation of the heme oxygenase-1 promoter, whereas the HSP70 gene promoter was activated upon heat shock. Such regulation of heme oxygenase-1 under thermal stress may be of physiologic significance in erythroid cells.
High-speed endless optical polarization stabilization using calibrated waveplates and field-programmable gate array-based digital controller (2008)

A truly endless polarization stabilization experiment with a tracking speed of 15 krad/s is presented. The high-speed polarization tracking is realized by using calibrated lithium niobate linear retardation waveplates as the polarization transformers combined with a very fast digital controller running on a field-programmable gate array (FPGA).
Liposome-based flow-injection immunoassay for determining theophylline in serum. (1993)

We developed a method for quantitatively determining theophylline in serum, using a heterogeneous immunoassay called flow-injection immunoanalysis. The reaction involves competition between serum theophylline and theophylline-labeled liposomes. Separation occurs on a solid-phase reactor column containing immobilized antibody to theophylline incorporated in a flow-injection system. Subsequent lysis of the bound liposomes provides sensitive detection of the analyte. Effective regeneration of the immobilized antibody activity allows the reactor to be reused for hundreds of sequential samples. Comparison of the results of the flow-injection immunoassay method with results obtained with a commercially available fluorescence polarization method showed an excellent correlation.
Analysis of peripheral and local anti‐tumor immune response in esophageal cancer patients after NY‐ESO‐1 protein vaccination (2008)

NY-ESO-1 antigen is a prototype of a class of cancer/testis antigens. We carried out a clinical trial using NY-ESO-1 whole protein as a cancer vaccine for 13 advanced cancer patients. We have recently reported that vaccine elicited humoral and cellular immune responses in 9 cancer patients including 4 esophageal cancer patients, and clinical responses were also observed in 4 of 5 evaluable patients. In this study, we analyzed the responses in 8 esophageal cancer patients including 4 newly enrolled patients. Patients were injected subcutaneously at biweekly intervals with NY-ESO-1 recombinant protein formulated with cholesterol-bearing hydrophobized pullulan. Induction of antibody, and CD4 and CD8 T-cell responses were observed in 7, 7 and 6 patients, respectively, out of 8 patients. 1 PR, 2 SD and 2 mixed clinical responses were observed in 6 evaluable patients. No significant adverse events were observed. Furthermore, we analyzed NY-ESO-1 and MHC class I expression and the infiltration of immune cells into tumor samples obtained before and after vaccination from 4 patients by immunohistochemistry. The results showed 2 patients with disappearance of CD4 and CD8 T-cell infiltration, 1 patient with increase in the number of CD68(+) macrophages and 1 patient with tumor antigen loss in the progressive tumors following vaccinations. The induction of NY-ESO-1 immunity and some preferable clinical outcomes were observed in esophageal cancer patients by vaccination with NY-ESO-1. However, the tumors grew eventually by various mechanisms after vaccination.
Monolithic Magneto-Optical Nanocomposites of Barium Hexaferrite Platelets in PMMA (2015)

The incorporation of magnetic barium hexaferrite nanoparticles in a transparent polymer matrix of poly(methyl methacrylate) (PMMA) is reported for the first time. The barium hexaferrite nanoplatelets doped with Sc(3+), i.e., BaSc0.5Fe11.5O12 (BaHF), having diameters in the range 20 to 130 nm and thicknesses of approximately 5 nm, are synthesized hydrothermally and stabilized in 1-butanol with dodecylbenzenesulfonic acid. This method enables the preparation of monolithic nanocomposites by admixing the BaHF suspension into a liquid monomer, followed by in-situ, bulk free-radical polymerization. The PMMA retains its transparency for loadings of BaHF nanoparticles up to 0.27 wt.%, meaning that magnetically and optically anisotropic, monolithic nanocomposites can be synthesized when the polymerization is carried out in a magnetic field. The excellent dispersion of the magnetic nanoparticles, coupled with a reasonable control over the magnetic properties achieved in this investigation, is encouraging for the magneto-optical applications of these materials.
Parachute Decelerate Trajectory Optimization Design Based on Genetic Algorithm (2009)

In this paper, the optimal parachute decelerating trajectory of mini-UAVs is studied. The mini-UAV trajectory model of parachute decelerating segment is established. The influences to parachute drag are analyzed and the parachute canopy limit area formula is derived. In order to ensure the time effectiveness of mini-UAVs entering working destination, taking flight time and range as the performance function, considering end velocity and end height as optimization constraints, and choosing parachute parameters-canopy area and parachute opening time as design variables, the optimal decelerating trajectory is solved by sequential quadratic programming method and genetic algorithm. Compared the results of these two kinds of optimized algorithms, their applicability to this decelerating trajectory is analyzed. The mechanism of timeliness during parachute decelerating trajectory is analyzed briefly. A numerical example results indicates the validity of the parachute decelerating trajectory design in this paper, which possesses practical value to guide research of parachute design.
Daniel Wuchters (1940)

40 D. WUCHTERS. LA MAGNANIMITY DE SCIPION. KAISER FRIEDRICH lVfusEUll3, BERLIN. Daniel Wuchters par ALEXANDRINE MILLER. e nom de famille Wuchters nous fait nous ressouvenir du peintre d'histoire et de portraits Abraham Wuchters, bien connu surtout en Danemark, ou il avait pass6 les trois quarts de sa vie. Ne vers 1610-1615 en Hollande, A. Wuchters habita Amsterdam jusqu'a 1637 1), ensuite vint en Danemark et v6cut à Sor6 et à Copenhague jusqu'A 1660. Cette ann6e-IA il visita la Suede ou il travailla a la cour de la reine Christine, n'ayant quitt6 Stockholm qu'au mois de decembre 1661 Pendant les ann6es
Ontogenetic Interactions between Photosynthesis and Symbiotic Nitrogen Fixation in Legumes (1977)

Photosynthetic data collected from Pisum sativum L. and Phaseolus vulgaris L. plants at different stages of development were related to symbiotic N(2) fixation in the root nodules. The net carbon exchange rate of each leaf varied directly with carboxylation efficiency and inversely with the CO(2) compensation point. Net carbon exchange of the lowest leaves reputed to supply fixed carbon to root nodules declined in parallel with H(2) evolution from root nodules. The decrease in H(2) evolution also coincided with the onset of flowering but preceded the peak in N(2) fixation activity measured by acetylene-dependent ethylene production. A result of these changes was that the relative efficiency of N(2) fixation in peas increased to 0.7 from an initial value of 0.4. The data reveal that attempts to identify photosynthetic contributions of leaves to root nodules will require careful timing and suggest that the relative efficiency of N(2) fixation may be influenced by source-sink relationships.
소식기사 : 용접구조용 내후성 열간 압연강재의 KS규격 개정내용에 관하여 (2003)

용접구조용 내후성 열간 압연강재(SMA : Steel for Marine Atmospheric)는 일반강재에 Cu, Cr, P, Ni 등의 내식성이 우수한 원소를 소량 첨가한 합금강으로서 스테인레스 등의 고합금강에 비해서는 뒤지지만 일반강재에 비해서는 4～8배의 내식성을 갖는 강재이다. 내후성강재는 도장용강재(Painting)와 무도장강재(Weathering)로 구분되며, 적용여건에 따라 선별적인 사용이 가능하다. 용접구조용 내후성 열간 압연강재에 관한 한국산업규격(KS 규격)은 KS D 3529로서 1977년 12월에 처음 제정된 이래 1984년의 1차 개정 후 사용되다가 2002년 12월에 2차 개정되어 현재 편집작업중에 있다. KS D 3529의 2차 개정은 대응하는 국제규격과의 부합화를 주목적으로 하고 있으며, 개정된 내용을 정리하면 다음과 같다.
Energy efficiency deterioration by variability in SRAM and circuit techniques for energy saving without voltage reduction (2012)

The transistor variability deteriorates the energy consumption in SRAM. Especially it increases the energy consumed at the bitlines, which is the major portion of the total energy. The influence of the variation is enhanced at lower supply voltage, thus the voltage reduction sometimes degrades the energy efficiency. In this paper, we present circuit techniques that can reduce the SRAM energy consumption without the supply voltage scaling. An energy-efficient hierarchical bitline scheme can save energy consumption used for the bitline precharge. An energy-efficient offset-cancelling circuit and a process-variability-robust timing-generating circuit are also proposed.
Novel Synthesis of (+/−)-<i>cis</i>-4-Amino-2-cyclopentene-1-methanol, a Key Intermediate in the Preparation of Carbocyclic 2′,3′-Didehydro-2′,3′-dideoxy Nucleosides (1992)

Abstract Novel synthetic routes directed toward the preparation of (+/−)-cis -4-amino-2-cyclopentene-1-methanol are described. The routes investigated involve azide openings of chiral and non-chiral cyclopentyl epoxides.
Metropolitan-area networks (1990)

Metropolitan-area networks (MAN), which fill the gap between local area networks (LANs) and wide-area networks (WANs), are discussed. MANs were originally oriented toward data, but now often carry voice and video traffic as well. Supplying more bandwidth than LANs, they support two-way communication over a shared medium such as an optical-fiber cable, and may offer point-to-point high-speed circuits or packet-switched communication. The two most favored topologies, double-star and double-ring, are described and emerging MAN protocols are examined.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Disruption of the NF-H Gene Increases Axonal Microtubule Content and Velocity of Neurofilament Transport: Relief of Axonopathy Resulting from the Toxin β,β′-Iminodipropionitrile (1998)

To investigate the role of the neurofilament heavy (NF-H) subunit in neuronal function, we generated mice bearing a targeted disruption of the gene coding for the NF-H subunit. Surprisingly, the lack of NF-H subunits had little effect on axonal calibers and electron microscopy revealed no significant changes in the number and packing density of neurofilaments made up of only the neurofilament light (NF-L) and neurofilament medium (NF-M) subunits. However, our analysis of NF-H knockout mice revealed an approximately 2.4-fold increase of microtubule density in their large ventral root axons. This finding was further corroborated by a corresponding increase in the ratio of assembled tubulin to NF-L protein in insoluble cytoskeletal preparations from the sciatic nerve. Axonal transport studies carried out by the injection of [35S]methionine into spinal cord revealed an increased transport velocity of newly synthesized NF-L and NF-M proteins in motor axons of NF-H knockout mice. When treated with beta,beta'-iminodipropionitrile (IDPN), a neurotoxin that segregates microtubules and retards neurofilament transport, mice heterozygous or homozygous for the NF-H null mutation did not develop neurofilamentous swellings in motor neurons, unlike normal mouse littermates. These results indicate that the NF-H subunit is a key mediator of IDPN-induced axonopathy.
Sialic acid of group B Neisseria meningitidis regulates alternative complement pathway activation (1987)

The effect of meningococcal cell-associated sialic acid on activation of the human alternative complement pathway was examined by using a quantitative fluorescence immunoassay to assess alternative pathway-mediated C3 binding to a group B strain of Neisseria meningitidis from which graded amounts of sialic acid had been removed with neuraminidase. Using human serum absorbed with strain B16B6 (B:2a:L2,3) and chelated with 10 mM MgCl2 and 10 mM ethylene glycol-bis(beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid, we found an increase in the amount of C3 bound by enzymatically desialylated B16B6 organisms over the amount bound by fully sialylated organisms. This increase was proportional to the amount of sialic acid cleaved from the bacteria. Enhanced C3 binding was accompanied by an increase in factor B deposition. A sialic acid-deficient mutant of strain B16B6, designated 2T4-1, bound C3 via the alternative pathway at a level equivalent to that bound by wild-type meningococci from which 88% of the sialic acid had been removed. Strain B16B6 was resistant to the alternative pathway-mediated bactericidal activity of both absorbed and hypogammaglobulinemic human sera, whereas noncapsular variant 2T4-1 was sensitive to these sera. The addition of purified immune immunoglobulin M (IgM) and IgG significantly increased the alternative pathway-mediated killing of strain B16B6 organisms. IgM mediated increased bactericidal activity without an increase in C3 or factor B deposition. In contrast, the IgG-mediated killing was associated with increased binding of C3 and factor B to the organisms. Absorption studies showed that the IgM bound to the sialic acid capsule, whereas the IgG bound to noncapsular surface antigens. We conclude from these results that the group B meningococcal sialic acid capsule inhibits activation of the alternative pathway in the nonimmune host and that both IgM and IgG, although specific for different surface antigens, are capable of augmenting the alternative pathway-mediated killing of group B meningococci.
DNA polymorphisms associated with the factor VIII:C gene in the Portuguese population. (1993)

We have determined the allele frequencies of seven restriction fragment length polymorphisms within or close to factor VIII:C gene in the Portuguese population. The allele frequency of all studied intra- and extragenic biallelic polymorphisms does not differ significantly from those found in other European or Asian populations. On the contrary, the distribution of the different alleles of the TaqI RFLP at the DXS52 locus revealed similarity only with Algerians. We observed a correspondence between the TaqI and BclI alleles at this locus.
Pitfalls and Opportunities for Environmental Marketers (1992)

Issues such as global warming, ozone depletion, insufficient landfill capacity, and excess packaging are foremost on the minds of consumers. Companies face a myriad of environmental challenges, but they also recognize the opportunities to be gained by implementing responsible marketing action plans.
Synthesis of bacterial polysaccharides via the Wzx/Wzy-dependent pathway (2014)

The surfaces of bacteria mediate a multitude of functions in the environment and in an infected host, including adhesion to both biotic and abiotic substrata, motility, immune system interaction and (or) activation, biofilm formation, and cell-cell communication, with many of these features directly influenced by cell-surface glycans. In both Gram-negative and Gram-positive bacteria, the majority of cell-surface polysaccharides are produced via the Wzx/Wzy-dependent assembly pathway; these glycans include heteropolymeric O-antigen, enterobacterial common antigen, exopolysaccharide, spore coat, and capsule in diverse bacteria. The key components of this assembly pathway are the integral inner membrane Wzx flippase, Wzy polymerase, and Wzz chain-length regulator proteins, which until recently have resisted detailed structural and functional characterization. In this review, we have provided a comprehensive synthesis of the latest structural and mechanistic data for each protein, as well as an examination of substrate specificity for each assembly step and complex formation between the constituent proteins. To complement the unprecedented explosion of genomic-sequencing data for bacteria, we have also highlighted both classical and state-of-the-art methods by which encoded Wzx, Wzy, and Wzz proteins can be reliably identified and annotated, using the model Gram-negative bacterium Pseudomonas aeruginosa as an example data set. Lastly, we outline future avenues of research, with the aim of stimulating researchers to take the next steps in investigating the function of, and interplay between, the constituents of this widespread assembly scheme.
Clinical, angiographic, and hemodynamic findings in patients with anomalous origin of the coronary arteries. (1976)

Clinical and angiographic features of 31 patients with anomalous coronpary artery origin are reviewed. Of 17 aberrant circumflex arteries from the right sinus of Valsalva or artery, each was retro-aortic, six atherosclerotic, and seven irrigated a small area of myocardium. Of seven anomalous right coronary arteries from the left sinus of Valsalva or artery, each was ante-aortic and two atherosclerotic. Aberrant origin of the circumflex or right coronary artery was a benign anomaly. The proximal course of seven aberrant left coronary arteries from the right sinus of Valsalva or right coronary artery was related to clinical events. The anomaly was best demonstrated in the lateral view. In five cases, coronary blood flow during exercise and myocardial metabolism during pacing were assessed. Two had had a previous infarction with nonatherosclerotic arteries. Exercise coronary blood flow was normal in four and low in one patient. Pacing resulted in lactate production in two with atherosclerotic and one without atherosclerotic arteries. We conclude that anomalous left coronpary origin from the right sinus of Valsalva can result in significant myocardial ischemia and infarction.
Assessing diagnosis in heart failure: which features are any use? (1997)

We assessed the value of symptoms, past history, medications and signs in the evaluation of patients who might have heart failure secondary to left ventricular systolic dysfunction. An open-access echocardiography service was set up to help identify patients with left ventricular systolic dysfunction who might benefit from treatment with an angiotensin-converting-enzyme inhibitor. History and examination were recorded for each of these patients. The patients were divided into groups according to whether left ventricular systolic function was preserved or not and whether various clinical features were present or not. Of 259 consecutive patients studied, 41 had impairment of left ventricular systolic function as assessed by echocardiography. Past history of myocardial infarction and displaced apex beat were the best single predictors of left ventricular systolic dysfunction as assessed by echocardiography. The combination of past history of myocardial infarction and displaced apex had the best positive predictive value of all. Patients with such clinical features or combinations of clinical features may not need echocardiography, and where access to this resource is limited, it could be reserved for patients without such diagnostic features.
Graph Classification and Clustering Based on Vector Space Embedding (2010)

This book is concerned with a fundamentally novel approach to graph-based pattern recognition based on vector space embedding of graphs. It aims at condensing the high representational power of graphs into a computationally efficient and mathematically convenient feature vector. This volume utilizes the dissimilarity space representation originally proposed by Duin and Pekalska to embed graphs in real vector spaces. Such an embedding gives one access to all algorithms developed in the past for feature vectors, which has been the predominant representation formalism in pattern recognition and related areas for a long time.
Studies of familial alcoholism: a review. (1984)

Recent studies demonstrate the existence of familial and nonfamilial types of alcoholism. The familial type is characterized by an early age of onset and a severe course. Nonfamilial alcoholism is more often associated with other adult psychiatric disorders. Adoption and twin data suggesting genetic influences in some forms of alcoholism are reviewed. Findings are summarized from studies comparing familial with nonfamilial alcoholics, and from high-risk studies in which sons of alcoholics are compared with sons of nonalcoholics. Both types of studies show important differences between familial and nonfamilial alcoholics.