gebhart/patrepeval huggingface dataset:
β-Conglycinin Embeds Active Peptides That Inhibit Lipid Accumulation in 3T3-L1 Adipocytes in Vitro (2008)

Obesity is a worldwide health concern because it is a well-recognized predictor of premature mortality. The objective was to identify soybean varieties that have improved potential to inhibit fat accumulation in adipocytes by testing the effects of soy hydrolysates having a range of protein subunit compositions on lipid accumulation and adiponectin expression in 3T3-L1 adipocytes. The results showed that differences in the protein distribution of 15 soy genotypes led to different potentials for the reduction of fat accumulation. The inhibition of lipid accumulation of soy alcalase hydrolysates in 3T3-L1 adipocytes ranged from 29 to 46%. Soy hydrolysates made from genotypes with 45.3 +/- 3.3% of total protein as beta-conglycinin, on average, showed significantly higher inhibition of lipid accumulation compared to those with 24.7 +/- 1.5% of extracted total protein as beta-conglycinin. Moreover, after in vitro simulated digestion with pepsin-pancreatin of the soy alcalase hydrolysates, 86% of the original activity remained. Adiponectin expression was induced in 3T3-L1 adipocytes treated with 15 soy hydrolysates up to 2.49- and 2.63-fold for high and low molecular weight adiponectin, respectively. The inhibition of lipid accumulation calculated from a partial least squares (PLS) analysis model correlated well with experimental data (R(2) = 0.91). In conclusion, it was feasible to differentiate soy varieties on the basis of the potential of their proteins to reduce fat accumulation using a statistical model and a cell-based assay in vitro. Furthermore, beta-conglycinin embeds more peptides than glycinin subunits that inhibit lipid accumulation and induce adiponectin in 3T3-L1 adipocytes. Therefore, soy ingredients containing beta-conglycinin may be important food components for the control of lipid accumulation in adipose tissue.
Metalation studies of trisubstituted oxazoles (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMetalation studies of trisubstituted oxazolesBruce H. Lipshutz and Randall W. HungateCite this: J. Org. Chem. 1981, 46, 7, 1410–1413Publication Date (Print):March 1, 1981Publication History Published online1 May 2002Published inissue 1 March 1981https://pubs.acs.org/doi/10.1021/jo00320a036https://doi.org/10.1021/jo00320a036research-articleACS PublicationsRequest reuse permissionsArticle Views205Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Aromatic Fluorine Compounds. IX. 2-Fluoropyridines<sup>1,2</sup> (1959)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAromatic Fluorine Compounds. IX. 2-Fluoropyridines1,2G. C. Finger and Laurence D. StarrCite this: J. Am. Chem. Soc. 1959, 81, 11, 2674–2675Publication Date (Print):June 1, 1959Publication History Published online1 May 2002Published inissue 1 June 1959https://pubs.acs.org/doi/10.1021/ja01520a021https://doi.org/10.1021/ja01520a021research-articleACS PublicationsRequest reuse permissionsArticle Views992Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Correction of B<sub>1</sub> inhomogeneities using echo‐planar imaging of water (1998)

Reliable interpretation of the MR signal intensity over the FOV of an image must consider the spatial heterogeneity of instrumental sensitivity. A major source of such variation is the nonuniformity of the B1 magnetic field of the radiofrequency coil. This heterogeneity can be minimized by coil design but is exaggerated by surface coils, which are used to maximize the signal-to-noise ratio for some applications. This paper describes a rapid method for mapping the B1 field over the sample of interest, using 1H echo-planar imaging, to correct for B1 distortions. The method applies to 1H imaging and has been extended to non-1H imaging by using dual-frequency coils in which the B1 distributions are matched for the 1H frequency and the frequency of interest. The approach is demonstrated in phantoms, animals, and humans and for sodium imaging.
Passive sonar detection and localization by matched velocity filtering (1995)

This paper presents a new bearings-only method of detecting and tracking low signal-to-noise ratio (SNR) wideband targets on a constant course and velocity trajectory. A track-before-detect strategy based on matched velocity filtering is adopted using spatial images constructed from a sequence of power bearing map (PBM) estimates accumulated during a track. To lower the threshold SNR for detection, a discrete bank of matched velocity filters integrates the PBM images over a range of hypothesized trajectories, such an approach eliminates the need to estimate the number of targets since signal detection is determined by comparing the output of each matched filter (MF) to a decision threshold. The distribution of the MF output is derived based on a single point target in diffuse noise assumption. Receiver operating characteristic curves show a definite detection gain under low SNR conditions for matched velocity filtering (track-before-detect) over detection from a single PBM.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
2013 Electrocardiographic estimate of ischemic acuteness is superior to time from pain onset for predicting myocardial salvage as assessed by SPECT and MRI in patients undergoing primary percutaneous coronary intervention (2008)

Introduction Based on animal studies, it is currently accepted that duration of ischemia is a major determinant of the ability to salvage jeopardized myocardium by restoring the coronary blood flow and myocardial perfusion. In experimental animal studies it is possible to determine the exact time of occlusion as well as to ensure complete, persistent ischemia during the time of coronary occlusion. In humans, however, it is impossible to determine either the exact time of acute occlusion or whether spontaneous reperfusion and re-occlusion has occurred prior to the time of reperfusion therapy.
Electrical and Optical Properties of Radio-Frequency-Sputtered Thin Films of (ZnO)<sub>5</sub>In<sub>2</sub>O<sub>3</sub> (1998)

c-Axis oriented thin films of (ZnO)5In2O3 of 0.5 μm thickness were deposited on glass substrates by a radio-frequency-sputtering method. The thin films had dense columnar structures and were highly transparent in the ultraviolet−visible region, simultaneously showing low electrical resistivity. The refractive index was about 2. The lowest resistivity, 1.3 × 10-3 Ω cm at room temperature, was obtained by reducing the deposited film at 540 °C in N2 containing 3.4% H2. The corresponding carrier concentration and Hall mobility were 1.9 × 1020 cm-3 and 25.6 cm2/Vs, respectively. Detailed analyses of the optical transmittance spectra gave rise to the intrinsic band gap and the reduced mass of carriers to be 3.12 eV and 0.67 m0, respectively.
TINA: A 3D Vision System for Pick and Place (1987)

Abstract The paper describes the Sheffield AIVRU 3D vision system for robotics. The system currently supports model-based object recognition and location; its potential for robotics applications is demonstrated by its guidance of a UMI robot arm in a pick-and-place task. The system comprises: recovery of a sparse depth map using edgebased passive stereo triangulation; grouping, description and segmentation of edge segments to recover a 3D description of the scene geometry in terms of straight lines and circular arcs; statistical combination of 3D descriptions for the purpose of object model creation from multiple stereo views, and the propagation of constraints for within-view refinement; and matching 3D wireframe models to 3D scene descriptions to recover an initial estimate of their position and orientation.
An automatic speech recognition system for bedside data entry in an intensive care unit (2002)

An automatic speech recognition system is being developed for a patient data management system (PDMS) in a pediatric intensive care unit (ICU). A number of bedside monitors are linked by a local area network to a personal computer for real-time acquisition of vital sign data and the graphical display of these trends. The PDMS also allows for the input of the fluid balance data, which is then processed by the system. An overview of the different speech recognition systems which provide speaker-dependent speech input are presented. A multimodal person-machine interface supporting data input and interaction by means of keyboard, mouse, or voice input is included. The integration of automatic speech recognition and the multimodal person-machine interface in the OS/2's Presentation Manager environment is discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Surface plasmon hybridization of whispering gallery mode microdisk laser (2010)

We study the effects of metal layers on the modes of microdisk lasers. It is found that metal layers hybridize the whispering gallery modes of microdisks with the surface plasmon modes. We observe a significant enhancement in the electric field normal to the metal layers. This hybridization effect can be utilized to design a surface plasmon source similar to laser for plasmonic applications.
A Self-Resonant MEMS-based Electrostatic Field Sensor with 4V/m/Hz Sensitivity (2006)

An electric-field sensor is presented for applications such as xerography. The sensor architecture combines a vibrating MEMS structure with synchronous detection-based electronics. Prototyped in a MEMS process, the noise floor is 4.0V/m/radicHz and the INL is 20V/m over a range of +/-700kV/m, an order-of-magnitude improvement over existing MEMS devices
A distributed routing algorithm for mobile radio networks (2003)

The authors present a distributed routing protocol intended for use in networks where the rate of topological change is not so fast as to make 'flooding' the only possible routing method but not so slow as to make one of the existing protocols for a static topology applicable. The routing algorithm adapts asynchronously in a distributed fashion to arbitrary changes in topology in the absence of global topological knowledge. The protocol maintains a set of loop-free routes to each destination from any node that desires a route. The protocol's performance, measured in terms of end-to-end packet delay and throughput, is compared with that of pure flooding and an alternative algorithm that is well suited to the medium-rate topological change environment envisioned here. The results show that, when the rate of topological change becomes very high, flooding is preferable to the other alternatives. For lower rate of change, it appears that, when the effects of channel access are accounted for, the performance of the new algorithm is encouraging in that it has been generally superior to that of the alternative protocols.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Loss of heterozygosity on 6q, 16q, and 17p in human central nervous system primitive neuroectodermal tumors. (1991)

The loss of genetic material from specific chromosomal locations in a given tumor type has been taken for evidence of the importance of tumor suppressor genes at these loci in the genesis of the tumor. The primitive neuroectodermal tumor of the central nervous system has such a loss on 17p in one-third of tumors. In this report, a detailed analysis of 17p loss in 23 tumors has been performed using 10 probes mapping to this region. In addition, an analysis for allelic deletion on chromosomes 6q, 16q, and 22q has been performed. Six of the 23 tumors showed loss of markers on 17p, and the area of common loss spanned 17p11.2 to 17pter. Five of 23 tumors showed loss of markers on 6q, and 3 showed loss on 16q. No tumor lost markers on 22q. Only one tumor showed loss at more than one location. These data suggest that primitive neuroectodermal tumors either are a heterogeneous group of tumors with more than one mechanism leading to a tumor or that more than one recessive oncogene may play a role in the genesis of these tumors.
Vale do Jequitinhonha: um vale de muitas culturas (2000)

O artigo visa a dar visibilidade à dimensão étnica presente na cultura e na história do Vale do Jequitinhonha. São descritas e analisadas situações que mostram a diversidade e a complexidade das relações que compõem o rico amálgama sociocultural do Vale, que aqui não pode ser encarado simplesmente como da “pobreza”, uma vez que guarda verdadeiros tesouros ao olhar do observador mais atento. A emergência de movimentos sociais que valorizam e revitalizam a memória indígena é um exemplo da vitalidade do Vale do Jequitinhonha, hoje.
Peptide Affinity and Concentration Affect the Sensitivity of M3-Restricted CTLs Induced In Vitro (1999)

In vitro stimulation of mouse splenocytes with hemagglutinin (HA) 173-190, a peptide derived from influenza virus hemagglutinin (A/JAP/305/57, H2N2), induces CTLs that are directed to the MHC class Ib molecule, H2-M3. M3 preferably binds peptides bearing an N-terminal formylmethionine. In this study, we show that several related nonformylated peptides can induce anti-HA CTLs in vitro: MLIIW (the minimal epitope), derived from HA186-190 at the C-terminal end of HA173-190; MLIIWG; MLIIWGV; and MLIIWGI, as well as formylated MLIIW. The heptamer peptides correspond to a polymorphism of HA192 in H2 strains of influenza; they have the highest relative affinities for M3 of the nonformylated peptides and higher affinities than some formylated mitochondrial peptides. Depending on the affinity of the peptide, a range of concentrations can be used to induce CTLs. One nanomolar of the high affinity f-MLIIW peptide can induce anti-HA CTLs, whereas 100-fold more of the lower affinity MLIIW peptide is needed. Lines induced with high concentrations (1 microM or greater) of f-MLIIW recognize Ag poorly, and the most efficient CTLs are induced with the lowest concentrations of peptide. Analysis with a panel of anti-TCRVbeta Abs shows that different T cells respond to high vs low peptide; the repertoire of cells responding to higher concentrations is more diverse, consistent with the expansion of more, but less efficient, clones. Thus, peptide affinity and concentration should be considered together for generating efficient antipeptide CTLs in vitro.
Re‐engineering the Polymer Capacitor, Layer by Layer (2016)

For the first time, a new re-engineered polarized capacitor architecture for high energy density storage is demonstrated. Thin charge blocking layers are introduced at the electrode/dielectric interfaces. The insertion of these blocking layers leads to a likely reduction of charge injection into the dielectric material and a more than 200 V μm−1 increase in the electric field breakdown of the dielectric.
Dependence of laser-induced breakdown field strength on pulse duration (1973)

Field strengths at which optical damage is initiated in NaCl have been measured with a mode-locked Nd: YAG laser with pulse durations of 15 and 300 psec. Comparison with previously reported data with a Q-switched laser shows that the field strength required for intrinsic optical damage increases by almost one order of magnitude from 106 V/cm at 10−8 sec to over 107 V/cm at 1.5 × 10−11 sec. This is in qualitative agreement with published estimates based on the electron avalanche breakdown mechanism.
Acetonitrile Formation from Ethylene and Ammonia over Zn2+ and Cd2+ Exchanged Y-zeolites (1994)

Abstract Zn2+ and Cd2+ exchanged Y-zeolites are found to be active for acetonitrile formation from ethylene and ammonia. Their catalytic activities are much higher than that on Al2O3, which has been known to be an active catalyst for this reaction.
Comparing layouts with HDL models: a formal verification technique (2003)

The authors discuss a formal verification technique using binary decision diagrams (BDDs) for comparing the functionality of a transistor netlist extracted from a layout with a design description in a hardware description language (HDL). A state machine is first abstracted from a transistor netlist, given information relating to clock signals and clock models. The resulting state machine behavior is then compared with another that is derived from the HDL description. The basic ingredients of the technique used can be directly applied (or, in other cases, extended) to various related contexts of interest.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A short synthesis of 5′‐<i>O</i>‐trityl‐protected <i>threo</i>‐ and <i>erythro</i>‐ 3′‐cyano‐3′‐deoxythymidine epimers using free‐radical chemistry (1992)

Abstract A reinvestigation of a synthetic route to 5′‐ O ‐trityl‐protected erythro ‐CNT that incorporates a modification of the Stork radical cyclization‐cyanation reaction generates an unexpected threo ‐epimer.
Computer Assisted Language Learning Based on Corpora and Natural Language Processing: The Experience of Project CANDLE (2005)

This paper describes Project CANDLE, an ongoing 3-year project which uses various corpora and NLP technologies to construct an online English learning environment for learners in Taiwan. This report focuses on the interim results obtained in the first eighteen months. First, an English-Chinese parallel corpus, Sinorama, was used as the main course material for reading, writing, and culture-based learning courses. Second, an online bilingual concordancer, TotalRecall, and a collocation reference tool, TANGO, were developed based on Sinorama and other corpora. Third, many online lessons, including extensive reading, verb-noun collocations, and vocabulary, were designed to be used alone or together with TotalRecall and TANGO. Fourth, an online collocation check program, MUST, was developed for detecting V-N miscollocation and suggesting adequate collocates in student’s writings based on the hypothesis of L1 interference and the database of BNC and the bilingual Sinorama Corpus. Other computational scaffoldings are under development. It is hoped that this project will help intermediate learners in Taiwan enhance their English proficiency with effective pedagogical approaches and versatile language reference tools.
Actinomycin prevents the destabilization of neurofilament mRNA in primary sensory neurons. (1992)

The levels of light, mid-sized, and heavy neurofilament (NF) mRNAs were compared to that of beta-actin mRNA in primary dissociated cultures of adult rat dorsal root ganglia (DRG). Decreases in the levels of all three NF mRNAs occur after 24 h in culture, mimicking the down-regulation of NF mRNAs in axotomized DRG neurons. The loss of NF mRNAs in DRG cultures is prevented by actinomycin and, to a lesser extent, by cycloheximide. Based on decay curves in actinomycin-treated cultures, the half-lives of NF mRNAs are at least 4 days in DRG neurons, but < 24 h in PC12 cells. Our data support the view that NF mRNAs are stabilized in DRG neurons and that stabilization prevents destabilization by a transcription-dependent process. We further propose that putative stabilizing factor(s) are able to prevent degradation of NF transcripts in intact neurons, but not in axotomized or cultured neurons.
Fully integrated high power RF front-end circuits in 2 GHz using 0.18um standard CMOS process (2008)

A high PA and an antenna switch were implemented in a single die with low noise amplifier to study feasibility of integration of all the RF front end components in a standard bulk CMOS process. Low voltage operation which is the biggest obstacle to implement a high power amplifier and a high power switch in the CMOS technology were resolved to by employing power combining technique using transformer and adaptive voltage swing distribution techniques. 30 dBm output power was obtained at 2 GHz with -40 dBc second and third harmonics. This is very promising data to open the possibility to integrate high power components in a standard CMOS process at cellular applications.
Coffee, tea, and caffeine consumption and risk of rheumatoid arthritis: Results from the Iowa Women's Health Study (2002)

Decaffeinated coffee intake is independently and positively associated with RA onset, while tea consumption shows an inverse association with disease onset. Further investigations of decaffeinated coffee and tea intake as arthritis risk factors are needed to verify these findings and explore their biologic basis.
Optimized Reconfigurable Fast Convolution-Based Transmultiplexers for Flexible Radio Access (2017)

Multirate fast-convolution (FC) processing can be used for realizing low-complexity filter banks (FBs) and transmultiplexers (TMUXs). The main advantage of the FC-based realizations when compared with the polyphase FBs is the increased configurability, that is, the number of subchannels, their bandwidths, and the center frequencies can be adjusted independently. In general, FC-based FBs are linear periodically shift-variant systems. In this brief, novel matrix representations for the FC synthesis and analysis FBs are first derived. These representations give all the shift-variant impulse responses of the FC-based FBs. Then the TMUX optimization criteria are expressed using these representations. Two examples are included to demonstrate the performance of the optimized designs as well as to illustrate the flexibility of the resulting FC-based TMUXs.
Fabrication of GaN dot structures on Si substrates by droplet epitaxy (2006)

Abstract Nanosized GaN dot structures were fabricated on Si(111) substrate by droplet epitaxy using an rf plasma MBE system. The size and density of the GaN dots could be controlled by changing the amount of Ga supplied. By reducing the Ga supply, a maximum dot density of 3.3 × 10 11 cm –2 was realized. Photoluminescence measurements at room temperature showed band edge emission with negligible yellow luminescence, which indicates a good optical property of GaN dots grown by this technique. (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)