gebhart/patrepeval huggingface dataset:
Binding sites for [<sup>3</sup>H]‐melatonin in human platelets (1992)

A number of in vitro effects of melatonin on human platelets were revealed in previous studies. In order to examine whether high affinity binding sites for [3H]-melatonin were present in membrane preparations of human platelets, a rapid filtration procedure through Whatman GFB paper was employed. Maximal melatonin binding was attained within 3 hr at 0 degree C. Scatchard analysis indicated a single population of binding sites with a dissociation constant (Kd) = 4.1 +/- 0.5 nM and maximal number of binding sites (Bmax) = 24.2 +/- 1.9 fmol/mg protein (mean +/- SEM of five experiments). When various indole analogs were tested for their ability to inhibit [3H]-melatonin binding, the following Ki (nM) were obtained: 6-chloromelatonin (11.4), 2-iodomelatonin (22.0), melatonin (24.7), 5-methoxytryptophol (49.9), N-acetylserotonin (68.9), 6-hydroxymelatonin (78.2), 5-methoxytryptamine (184). Serotonin was a potent inhibitor of [3H]-melatonin binding with a Ki = 20.6 nM. Except for 2-methylserotonin and alpha-methylserotonin, a number of serotonin agonists and antagonists tested did not affect melatonin binding to platelet membranes. Binding experiments carried out at either 0800 or 2000 did not reveal time-dependent differences in Kd or Bmax. The results suggest that high affinity melatonin acceptors are present in human platelets.
Current and Future Trends in Imaging Informatics for Oncology (2011)

Clinical imaging plays an essential role in cancer care and research for diagnosis, prognosis, and treatment response assessment. Major advances in imaging informatics to support medical imaging have been made during the last several decades. More recent informatics advances focus on the special needs of oncologic imaging, yet gaps still remain. We review the current state, limitations, and future trends in imaging informatics for oncology care including clinical and clinical research systems. We review information systems to support cancer clinical workflows including oncologist ordering of radiology studies, radiologist review and reporting of image findings, and oncologist review and integration of imaging information for clinical decision making. We discuss informatics approaches to oncologic imaging including, but not limited to, controlled terminologies, image annotation, and image-processing algorithms. With the ongoing development of novel imaging modalities and imaging biomarkers, we expect these systems will continue to evolve and mature.
Guest Editorial (1994)

Editor's Note, Interest in a mathematics education journal devoted exclusively to research began to develop at least as long ago as the mid-1950s, but it wasn't until the publication of the NCTM monograph. Research in Mathematics Education, in 1967 that sufficient impetus existed to establish one. The first issue of the Journal for Research in Mathematics Education appeared in January 1970 with David C. Johnson as its editor.
A modal analysis and modelling of a lightly damped large space structure (1992)

This study involves the modification to the PACOSS Dynamic Test Article to create a lightly damped representative large space structure with closely spaced, low frequency modes. An experimental modal analysis is performed to recharacterize the low frequency flexible vibration modes. A finite element model is created using MSC/NASTRAN to predict low frequency behavior using both real eigenvalue analysis and frequency response analysis. Then a reduced order model is created and fine-tuned to represent the dynamics of the structure for the identified low frequency modes.
Accelerator Structure for Low-Energy Electron Beam (1994)

A special high quality bunching cell for low-energy electron beam pre-acceleration is described. This cell was tested in an X-band standing wave accelerator. 25-keV electrons were injected into this bunching cell, connected to a linac structure, and more than 50% of them accelerated to the nominal energy. >
A First-in-Human, Phase I, Dose-Escalation Study of TAK-117, a Selective PI3Kα Isoform Inhibitor, in Patients with Advanced Solid Malignancies (2017)

<b>Purpose:</b> To evaluate the safety, MTD, pharmacokinetics, pharmacodynamics, and preliminary antitumor activity of TAK-117 (MLN1117/INK1117), an investigational PI3Kα-selective inhibitor, in patients with advanced solid tumors.<b>Experimental Design:</b> Seventy-one patients received oral TAK-117 once daily [100-300 mg (<i>n</i> = 24)] or 3 days per week [Monday-Wednesday-Friday (MWF), 200-1,200 mg (<i>n</i> = 27); Monday-Tuesday-Wednesday (MTuW), 200-900 mg (<i>n</i> = 20)], in 21-day cycles. Dose escalation proceeded via a 3 + 3 design.<b>Results:</b> TAK-117 once-daily dosing was associated with dose-limiting grade ≥3 alanine/aspartate aminotransferase (ALT/AST) elevations, resulting in a narrow range of tolerable doses (100-150 mg once daily). With MWF/MTuW dosing, no dose-limiting ALT/AST elevations occurred until the MTD of 900 mg; total weekly dose was 2.6-fold that of 150 mg once daily. Drug-related grade ≥3 adverse events occurred in 25%/22%/35% (including hyperglycemia in 0%/7%/15%) of once-daily/MWF/MTuW patients. TAK-117 (100-1,200 mg) exhibited moderately fast oral absorption, a generally dose proportional increase in exposure, and plasma half-life of approximately 11 hours. Total weekly exposures with 900 mg MWF/MTuW dosing were approximately 4 times greater than with 150 mg once daily. Skin pS6 expression was suppressed at ≥200 mg. There were 3/1/0 partial responses (once daily/MWF/MTuW) and 5/7/5 patients had stable disease lasting ≥3 months (all <i>PIK3CA</i> mutated).<b>Conclusions:</b> Intermittent dosing of TAK-117 had an acceptable safety profile and enabled higher doses and total weekly exposures versus once-daily dosing. Although the potential for TAK-117 as single-agent therapy appears limited, further evaluation in combination approaches for advanced solid tumors is warranted. <i>Clin Cancer Res; 23(17); 5015-23. ©2017 AACR</i>.
Highly Directional Emission and Beam Steering from Organic Light‐Emitting Diodes with a Substrate Diffractive Optical Element (2014)

Highly directional emission from an organic light-emitting diode (OLED) is demonstrated by out-coupling the substrate mode from a Eu-based OLED using a diffractive optical element embedded in the substrate. This approach gives emission that is confined in a single narrow cone with FWHM divergence of 15° or less, which is very different from the normal Lambertian emission of OLEDs.
Embedding in large plastic blocks. Diagnostic light and potential electron microscopy on the same block. (1979)

Specimens destined for light and electron microscopy were fixed in a modified buffered formalin, postosmicated, dehydrated, and embedded in a mixture of epoxy resins (Epon-araldite) in large plastic molds. These blocks were sectioned at 0.5 to 1 micron on a JB-4 microtome and stained with a combined nuclear and cytoplasmic stain (Paragon). The sections were examined by light microscopy for diagnostic evaluation. If ultrastructural examination was also desired, the selected area was isolated using the "mesa" technique. The trimmed block was then sectioned on an ultramicrotome, picked up on grids, stained, and examined in the electron microscope. We think these techniques offer the diagnostic pathologist the potential of viewing 1-micron sections at a light microscopy level with the option of subsequent electron microscopy of the same area of the same block.
Infrared He–Xe laser interferometry for measuring length (1981)

A technique is described for determining absolute lengths up to 3 m from measurement of the interference fringe fractions for multiple wavelengths. The required accuracies of the wavelength ratio and fringe fraction reading are analyzed. To satisfy the accuracies, a low-cost simply stabilized He-Xe laser, operating simultaneously at two wavelengths, 3.51 and 3.37 microm, was developed. Using this laser the preliminary measurement of the wavelength ratio was made interferometrically with the length standard of a gauge block.
A segmentation method to improve iris-based person identification (2005)

The authentication of individuals using iris-based recognition is a widely developing technology. Precise and unobtrusive image acquisition is not always possible. This introduces a number of ill-affecting factors to the subsequent localisation and characterisation stages. Common problems include variations in lighting, poor image quality, noise and interference caused by eyelashes. The feature extraction and classification procedures rely heavily on the rich textural details of the iris to provide a unique digital signature for an individual. As a result, the stability and integrity of a system depends on effective segmentation of the iris to generate the iris-code. The previously mentioned problems hinder this task. A new segmentation method is presented to tackle these problems. Principal component analysis (PCA) is discussed as a preprocessing technique that removes redundant and useless data. Variations in lighting; and noise are handled using an application of median filtering and adaptive thresholding. Finally, edge detection and the Hough transform are discussed for locating the circular boundaries of the pupil and sclera.
Effect of Neck Muscle Strength and Anticipatory Cervical Muscle Activation on the Kinematic Response of the Head to Impulsive Loads (2014)

Neck strength and impact anticipation are 2 potentially modifiable risk factors for concussion. Interventions aimed at increasing athletes' neck strength and reducing unanticipated impacts may decrease the risk of concussion associated with sport participation.
Preparation and Activity of a Nanometer Anti-microbial Polyurethane (2009)

为有干扰素的相片固定的一个新奇方法 -- 聚氨酯(PU ) 的表面上的 α (IFN-α ) 材料，以后使 PU 避孕套成为更多的有效功能，被调查。一种光敏的 arylazide-4-azidobenzoic 酸与红外和拉曼光谱的证实被修改到 IFN-α 。使相片不能调动的房间因素的微形态学被 FESEM 在纳米的水平象 CSLM 一样观察。最后，有抗菌剂的基本测试的产品也被评估。
Adverse events with bismuth salts for Helicobacter pylori eradication: Systematic review and meta-analysis (2008)

Bismuth for the treatment of H pylori is safe and well-tolerated. The only adverse event occurring significantly more commonly was dark stools.
A Low-Power WLAN Communication Scheme for IoT WLAN Devices Using Wake-Up Receivers (2018)

In this paper, we propose a delay- and power-efficient, multi-user, low-power wireless local area network (WLAN) communication scheme for Internet of Things (IoT) WLAN devices. Extremely low-power operation is one of the key requirements of emerging IoT devices. However, the current duty-cycle-based power saving approach may incur large access delay times owing to the trade-offs between the power consumption and the access delay. In order to reduce this delay and enhance the power-saving performance, wake-up receiver-based schemes have been proposed. However, because wake-up receiver-based schemes do not consider multiuser operation in dense communication environments, large delays are inevitable in the case of multiuser operation. In order to provide extremely low-power operation and under 1-mW standby power with reduced delay, we employed the optimized multiuser transmission scheduling of IEEE 802.11ax in the proposed scheme and proper enhanced distributed channel access (EDCA) parameter settings. This is with the aim to reduce the delay caused by long wake-up times, and to avoid collisions caused by simultaneous transmission in uplink multiuser scenario. By using the proposed scheme, simultaneous IoT communication with multiple mobile IoT devices is possible while providing low-power operation. Simulation results verified the outstanding delay performance of the proposed scheme.
THE STRUCTURE AND MECHANICAL PROPERTIES OF FIBRES (1962)

Abstract Possible forms of structure in fibres are described, together with a list of sources of evidence. The effects of nucleation and growth of crystals in man-made fibres are shown to influence fibre structure. Opinions of the most likely structure in vegetable fibres, wool and hair fibres, regenerated cellulose fibres, and synthetic fibres are expressed, and interpretations of mechanical properties are considered.
Simultaneous Detection of <i>Staphylococcus aureus</i> and Coagulase-Negative Staphylococci in Positive Blood Cultures by Real-Time PCR with Two Fluorescence Resonance Energy Transfer Probe Sets (2004)

A real-time PCR assay that uses two fluorescence resonance energy transfer probe sets and targets the tuf gene of staphylococci is described here. One probe set detects the Staphylococcus genus, whereas the other probe set is specific for Staphylococcus aureus. One hundred thirty-eight cultured isolates, which contained 41 isolates of staphylococci representing at least nine species, and 100 positive blood cultures that contained gram-positive cocci in clusters were tested. This assay was 100% sensitive and 100% specific for the detection of the Staphylococcus genus and of S. aureus.
ChemInform Abstract: SYN REGIOSELECTIVITY OF THE HYDROPEROXIDATION OF CYCLOALKENES WITH SINGLET OXYGEN (1981)

Abstract Die Alkylcycloalkene (I) liefern nach Photooxidation mit Singulett‐Sauerstoff und anschließender Reduktion Gemische der Reaktionsprodukte (II)‐(IV).
Decision trees for entity identification (2007)

We consider the problem of constructing decision trees for entity identification from a given relational table. The input is a table containing information about a set of entities over a fixed set of attributes and a probability distribution over the set of entities that specifies the likelihood of the occurrence of each entity. The goal is to construct a decision tree that identifies each entity unambiguously by testing the attribute values such that the average number of tests is minimized. This classical problem finds such diverse applications as efficient fault detection, species identification in biology, and efficient diagnosis in the field of medicine. Prior work mainly deals with the special case where the input table is binary and the probability distribution over the set of entities is uniform. We study the general problem involving arbitrary input tables and arbitrary probability distributions over the set of entities. We consider a natural greedy algorithm and prove an approximation guarantee of O(rK • log N), where N is the number of entities and K is the maximum number of distinct values of an attribute. The value rK is a suitably defined Ramsey number, which is at most log K. We show that it is NP-hard to approximate the problem within a factor of Ω(log N), even for binary tables (i.e. K=2). Thus, for the case of binary tables, our approximation algorithm is optimal up to constant factors (since r2=2). In addition, our analysis indicates a possible way of resolving a Ramsey-theoretic conjecture by Erdos.
Low-Complexity Soft-Output Mimo Detection In Fbmc/Oqam Systems (2014)

This paper focuses on soft-output detection when coded spatial data multiplexing schemes are combined with<br> filter bank multicarrier systems based on the offset quadrature amplitude modulation (FBMC/OQAM). Due to the modulationinduced interference, which is inherent to FBMC/OQAM, the soft detection is not trivial. The proposed technique circumvents this problem by removing the interference with reduced complexity.<br> The complexity of the proposed receiver and the system performance are evaluated and compared with the equivalent<br> OFDM one. When the receiver has more antennas than the transmitter, both schemes give similar performance thus, supporting FBMC/OQAM, which presents less complexity.
Sibinia arenariae Steph. (Col.: Curculionidae) in west Kent (1985)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
Iron‐Catalyzed Alkylations of Aromatic Grignard Reagents (2007)

Nicht zum alten Eisen: Zwei effiziente eisenkatalysierte Kreuzkupplungen von Aryl-Grignard-Reagentien mit Alkylbromiden eignen sich für die Anwendung im großen Maßstab. Das erste Verfahren nutzt Eisenacetylacetonat und einen kooperativen Effekt der Liganden N,N,N′,N′-Tetramethylethylendiamin (TMEDA) und Hexamethylentetraamin (HMTA), im zweiten dient [(FeCl3)2(tmeda)3] als Katalysator. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2001/2007/z700742_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Influenza and influenza vaccination. (1980)

The hemagglutinin and neuraminidase surface antigens of the influenza virus periodically undergo major or minor structural changes. These influence epidemiologic patterns and the composition of vaccine. Annual vaccination is recommended for individuals at increased risk of complications from lower respiratory tract infections. Vaccine for 1979-80 contains antigens representative of three viruses and is closely related to the vaccine of 1978-79. Amantadine is approved for prophylaxis and treatment.
Use of Polar Aprotic Solvents to Release Membranes from Milk Lipid Globules (1987)

In the search for alternatives to physical methods for release of membranes from milk lipid globules, aqueous solutions of the polar aprotic solvents dimethyl sulfoxide and dimethyl formamide were found to cause release of milk fat globule membrane. Membranes released with polar, aprotic solvents displayed some differences in polypeptide, enzymatic, and lipid composition in comparison with membranes released by churning. However, all polypeptide, enzymatic, and lipid constituents measured in membranes released by churning were also present in membranes released with dimethyl formamide and dimethyl sulfoxide. Antigenic and Concanavalin A binding activity of polypeptides was retained during exposure to dimethyl sulfoxide or dimethyl formamide. The solvent method was effective in releasing membrane from lipid globules of cow, rat, and guinea pig milks. This solvent method was rapid and minimized losses attendant with physical methods for release of milk fat globule membrane.
GADD34–PP1c recruited by Smad7 dephosphorylates TGFβ type I receptor (2004)

The cascade of phosphorylation is a pivotal event in transforming growth factor beta (TGFbeta) signaling. Reversible phosphorylation regulates fundamental aspects of cell activity. TGFbeta-induced Smad7 binds to type I receptor (TGFbeta type I receptor; TbetaRI) functioning as a receptor kinase antagonist. We found Smad7 interacts with growth arrest and DNA damage protein, GADD34, a regulatory subunit of the protein phosphatase 1 (PP1) holoenzyme, which subsequently recruits catalytic subunit of PP1 (PP1c) to dephosphorylate TbetaRI. Blocking Smad7 expression by RNA interference inhibits association of GADD34-PP1c complex with TbetaRI, indicating Smad7 acts as an adaptor protein in the formation of the PP1 holoenzyme that targets TbetaRI for dephosphorylation. SARA (Smad anchor for receptor activation) enhances the recruitment PP1c to the Smad7-GADD34 complex by controlling the specific subcellular localization of PP1c. Importantly, GADD34-PP1c recruited by Smad7 inhibits TGFbeta-induced cell cycle arrest and mediates TGFbeta resistance in responding to UV light irradiation. The dephosphorylation of TbetaRI mediated by Smad7 is an effective mechanism for governing negative feedback in TGFbeta signaling.
Speed up deep neural network based pedestrian detection by sharing features across multi-scale models (2015)

Deep neural networks (DNNs) have now demonstrated state-of-the-art detection performance on pedestrian datasets. However, because of their high computational complexity, detection efficiency is still a frustrating problem even with the help of Graphics Processing Units (GPUs). To improve detection efficiency, this paper proposes to share features across a group of DNNs that correspond to pedestrian models of different sizes. By sharing features, the computational burden for extracting features from an image pyramid can be significantly reduced. Simultaneously, we can detect pedestrians of several different scales on one single layer of an image pyramid. Furthermore, the improvement of detection efficiency is achieved with negligible loss of detection accuracy. Experimental results demonstrate the robustness and efficiency of the proposed algorithm. (C) 2015 The Authors. Published by Elsevier B.V.
A meta model and an infrastructure for the non-transparent replication of object databases (2000)

The distribution of data within or between organizations is crucial for many applications. Such a distribution may be transparent, as it is embodied in distributed database systems to increase their performance, reliability and availability. Other systems either do not require transparent data distribution or even explicitly need their own copies of the data. Examples are data warehouses which collect base data from different transaction processing systems, or financial data distribution systems in banking where data are bought from external providers and distributed to different working groups. Such systems need non-transparent, partial and selective replication of databases. If object databases are used, appropriate replication systems have to cope with the additional complexity of object models. Todays replication systems do not meet these requirements. Consequently, we introduce a meta model that specifies the abstract functionality which is needed for the non-transparent, partial and selective replication of object databases. This meta model allows incorporation of its replication concepts in a variety of object models. In addition, we present the design of a replication infrastructure, based on the meta model, which serves as the foundation for concrete realizations of object replication systems. The development of a replication system for a time series database management system proved the viability of the proposed solution.
Follicle-stimulating hormone (FSH) during the secondary surge in gilts as influenced by administration of porcine follicular fluid (pFF). (1991)

The effect of volume and frequency of administration of porcine follicular fluid (pFF) on FSH concentration was determined in mature gilts during the period of the secondary FSH surge (d 0 to 5; d 0 = onset of estrus) and following withdrawal of pFF (d 5.5 to 9). Crossbred gilts (n = 14) were randomized in a 3 x 2 factorial treatment design involving three doses of pFF (0, 5, or 10 ml) and once- vs twice-daily pFF administration. Porcine FF was aspirated from medium and large follicles and treated with 5 mg of activated charcoal per milliliter of pFF to remove steroids. Once-daily administration of pFF, regardless of dose, failed to suppress mean concentrations of FSH during the secondary FSH surge. Treatment of gilts twice daily with 10 ml of pFF suppressed (P less than .05) area under the FSH curve during the secondary FSH surge compared with gilts given saline. Gilts treated twice daily with 5 ml pFF showed comparable suppression of plasma FSH from d 0 to 3 but began to overcome FSH inhibition after d 3. As a result, FSH release only tended to be lower than controls for the entire treatment period (P less than .1). Mean FSH concentrations were increased (P less than .05) during the post-treatment period (d 5.5 to 9) by treatment with intermediate (5 ml pFF, two times daily and 10 ml pFF, one time daily) and high (10 ml pFF, two times daily) doses of pFF. Neither ovulation rate nor interestrous interval was affected by pFF administration.(ABSTRACT TRUNCATED AT 250 WORDS)
Sensitivity Analysis in Linear Regression. (1989)

The Prediction Matrix Role of Variables in a Regression Equation Effects of an Observation on a Regression Equation Assessing the Influence of Multiple Observations Joint Impact of a Variable and an Observation Assessing the Effect of Errors of Measurements A Study of Model Sensitivity by the Generalized Linear Model Approach Computational Considerations. Appendix: Summary of Vector and Matrix Norms, Proofs of Three Theorems.