gebhart/patrepeval huggingface dataset:
The Identification of Fibrinopeptide B as a Chemotactic Agent Derived from Human Fibrinogen (1974)

Chemotactic activity for human peripheral blood leucocytes was generated by the action of thrombin on human fibrinogen, a reaction known to release low molecular weight fibrinopeptides. Following gel filtration of the clot supernatant most of the activity eluted at the same K d as synthetic fibrinopeptides. Fibrinopeptides present in the clot supernatant were then identified and separated by high voltage electrophorcsis in two dimensions. Chemotactic activity was a property of fibrinopeptide B and not of fibrinopeptides A, AP or AY. Supernatants prepared with contortrix venom, which cleaves the B peptide, were also chemotactic whereas no activity was present in supernatants prepared from Arvin venom which cleaves peptides A, AP and AY. Synthetic fibrinopeptide B and a B analogue, 1‐glutamic acid, were found to be chemotactic but not synthetic fibrinopeptide A. Thus chemotaxis of human leucocytes represents a further biological activity of fibrinopeptide B.
Bidirectional interpretation of XQuery (2007)

XQuery is a powerful functional language to query XML data. This paper gives a bidirectional interpretation of XQuery to address the problem of updating XML data through materialized XQuery views. We first design an expressive bidirectional transformation language, and then translate XQuery expressions into the code of this language. As a result, an XQuery expression can execute in two directions: in the forward direction, it generates a materialized view from the source XML data; while in the backward direction, it updates the source data by putting back the updates on the view. we have implemented our approach and applied it to some XQuery use cases from a W3C draft, which confirms the practicability of this approach.
New noninvasive transcutaneous approach to blood glucose monitoring: successful glucose monitoring on human 75 g OGTT with novel sampling chamber (1991)

A novel noninvasive and quasi-continuous method of transcutaneous blood glucose monitoring for use with the human 75 g oral glucose tolerance test (OGTT) has been developed. The effused fluid was obtained by applying suction on the skin surface and labeled suction effusion fluid (SEF). The system consists of two main parts: a suction apparatus and the glucose sensor system. The suction apparatus applies vacuum to the patient's skin at 400 mmHg absolute pressure to collect the SEF. The miniature ion sensitive field effect transistor (ISFET) based glucose sensor can measure glucose in small SEF quantities. The monitoring system is based on the association between the glucose concentration in the SEF and in the serum. During the 75 g OGTT, the glucose change in the SEF was measured every 10 min. Although a response delay of up to 20 min was observed in the SEF glucose change, it was possible to perform the 75 g OGTT by this noninvasive monitoring method.
Sequence-specific DNA interactions by novel alkylating anthracycline derivatives. (1995)

New alkylating anthracycline derivatives with promising antitumor activity have been synthesized. We selected two of these compounds, 4-demethoxy-N,N-bis(2 chloroethyl)-4'-methylsulfonyl-daunorubicin (FCE 27726) and 4-demethoxy-3'-deamino-3'aziridinyl-4'-methylsulfonyl daunorubicin (FCE 28729), comparing their interaction with DNA and that of the non-alkylating derivative 4-demethoxy-4'-methylsulfonyl-daunorubicin (FCE 27894). The two alkylating derivatives were more cytotoxic than idarubicin and presented low cross-resistance with doxorubicin. Both FCE 27726 and FCE 28729 were found to alkylate guanines at the N7 position in the major groove with roughly the same specificity, but at different concentrations. FCE 27726 was 10 times more potent than FCE 28729 in alkylating DNA. At higher concentrations, FCE 27726 was able to alkylate adenines, possibly at the N3 position contained in a sequence 5'-PyAA. FCE 27726, as expected, was able to form DNA interstrand cross-links either in vitro and in vivo in treated cells. FCE 28729 did not form DNA interstrand cross-links in vivo. In vitro, at high concentrations, some DNA interstrand cross-links were evident. The non-alkylating derivative FCE 27894 did not produce any alkylation or DNA interstrand cross-links either in vitro or in vivo.
Synthesis and stopped-flow investigation of antioxidant activity of tocopherols. Finding of new tocopherol derivatives having the highest antioxidant activity among phenolic antioxidants (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and stopped-flow investigation of antioxidant activity of tocopherols. Finding of new tocopherol derivatives having the highest antioxidant activity among phenolic antioxidantsKazuo Mukai, Kazuya Okabe, and Hironobu HososeCite this: J. Org. Chem. 1989, 54, 3, 557–560Publication Date (Print):February 1, 1989Publication History Published online1 May 2002Published inissue 1 February 1989https://doi.org/10.1021/jo00264a011RIGHTS & PERMISSIONSArticle Views480Altmetric-Citations78LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (547 KB) Get e-Alerts Get e-Alerts
Increasing cache port efficiency for dynamic superscalar microprocessors (1996)

The memory bandwidth demands of modern microprocessors require the use of a multi-ported cache to achieve peak performance. However, multi-ported caches are costly to implement. In this paper we propose techniques for improving the bandwidth of a single cache port by using additional buffering in the processor, and by taking maximum advantage of a wider cache port. We evaluate these techniques using realistic applications that include the operating system. Our techniques using a single-ported cache achieve 91% of the performance of a dual-ported cache.
Microstructure and Corrosion Studies for Optimized PWR and BWR Zircaloy Cladding (1989)

The increased discharge burnups envisaged today require an optimization of the Zircaloy cladding properties with regard to corrosion with different strategies for optimizing the corrosion for boiling water reactor (BWR) and pressure water reactor (PWR) applications. A broad laboratory study showed that the influence of temperature and environmental details upon autoclave test results is rather complex. Zircaloy with fine (∼ 0.05 μm), uniformly distributed intermetallic precipitates reveals nodular corrosion in steam at 420°C or below and excessive uniform corrosion in water at 350°C, but the best nodular behavior in steam at 500#x00B0;C. However, samples with larger intermetallic precipitates (&gt;0.2 μm) exhibit a strong tendency to nodular corrosion in 500°C steam, but good behavior in steam at 420°C or below and in water at 350°C. The tendency toward nodular corrosion in 400 to 500°C steam can be suppressed by additions of oxygen; the ranking in uniform corrosion in 350°C water can be altered by additions of hydrogen. The latter was observed on samples exposed up to 1000 days in degassed water and afterwards 1000 days in water with a hydrogen overpressure. Similar correlations were found for in-pile exposure with some exceptions. Materials with very fine intermetallic precipitates, which show little tendency for nodular corrosion and behave well in-pile in oxygenated (mostly BWR) environments, exhibit accelerated uniform corrosion in a hydrogenated (PWR) environment with a corrosion rate that depends very little on temperature. However, in oxygenated coolant, materials with coarse precipitates indicate severe nodular corrosion, which is almost independent of the temperatures within the range of 290 and 350°C. As a result of these findings a dual strategy is technologically feasible by using different values of the accumulated annealing parameters (Σ Ai) for BWR and PWR application. For optimized BWR cladding tubes ΣAi ⩽ 10 -18 h is proposed; the best range for PWR cladding appears to be at 2 × 10-18 h ⩽ Σ Ai ⩽ 5 × 10-17 h.
Phytoestrogens: Recent Developments (2003)

Phytoestrogens are polyphenolic non-steroidal plant compounds with estrogen-like biological activity. Based on their chemical structure, phytoestrogens can be classified into four main groups, i. e., isoflavonoids, flavonoids, stilbenes, and lignans. For each group, the chemistry, dietary sources and biotransformation of the most interesting compounds will be discussed. Since phytoestrogens are structurally very similar to the estrogen 17beta-estradiol, they may exhibit selective estrogen receptor modulating activities. Therefore, special attention will be given to the hormonal effects of various isoflavonoids, including genistein, daidzein, coumestrol and equol, several prenylated flavonoids, especially 8-prenylnaringenin, and the stilbene resveratrol. Furthermore, their non-hormonal effects will be discussed briefly. Finally, the latest developments on the potential protective properties of phytoestrogens and phytoestrogen-containing foods against hormone-dependent breast and prostate cancers and cardiovascular diseases, and as estrogen replacement therapy for postmenopausal women will be discussed.
Innate Immune Regulation of<i>Serratia marcescens</i>–Induced Corneal Inflammation and Infection (2012)

S. marcescens induces corneal inflammation by activation of TLR4/MD-2/MyD88 and the IL-1R1/MyD88 pathways, which are potential therapeutic targets for inhibition of S. marcescens-induced corneal inflammation.
병기 3 위선암에서 nm23 단백발현의 임상병리학적 및 예후적 의미 평가 (1998)

Objective: Gene expression of nm23 has been investigated in a number of tumors, including breast cancer, colon cancer, malignant melanoma, and hepatocellular carcinoma. Its down-regulation has been shown to be associated with metastasis or disease progression in some of the tumors. This study was carried out to define the relationship between nm23 protein expression and clinicopathological variables. Methods: nm23 protein levels were investigated in 64 surgically resected specimens of stage Ⅲ gastric cancer by immunohistochemical method, and association with clinicopathological parameters and survival rates were determined. Results: The overall expression rates of nm23 was 68.7 %. There was no significant difference between nm23 protein expression and clinicooathological variables such as age, sex, stage, histology, tumor depth, number of metastatic nodes, tumor size, site and method of operation. Statistically, no significant differences between nm23 protein expression and overall survival rates were found. Conclusions: These results suggest that nm23 protein expression is an unsatisfactory prognostic indicator in stage III gastric adenocarcinoma.
Efficient resource allocation in self-healing multiprotocol label switching mesh networks (2002)

This paper presents a restoration scheme to minimize spare bandwidth reservation of bandwidth guaranteed paths that can recover 100% from single failure in MPLS mesh networks. Our new algorithm establishes multiple backup LSP for each primary LSP while backup LSP are multiplexed efficiently to reduce the resource reserved for backup LSP. The new scheme has several advantages compared with current work: the overall resource requirements for backup paths are reduced by about 20% to 30%; it balances the network resource utilization during the backup path reservation stage, it also balances the network load at path switchover stage. The new algorithm can admit more bandwidth guaranteed flows and it can improve the survivability of the networks. It can recover from multiple link failures when it is used with admission control. We extend the RSVP protocol to support our path restoration scheme in MPLS networks. We present the procedures to setup the backup paths, perform label binding and reserve backup resources. Explicit notification is utilized to improve the response time of network failover.
Laser generation and detection of surface acoustic waves: Elastic properties of surface layers (1992)

A noncontact all-optical method for surface photoacoustics is described. The surface acoustic waves (SAWs) were excited employing a KrF laser and detected with a Michelson interferometer using a 633-nm HeNe laser. Due to an active stabilization scheme developed for the interferometer a surface displacement of 0.2 Å could be detected. The materials investigated included pure materials such as polycrystalline aluminum, and crystalline silicon; films of gold, silver, aluminum, iron, and nickel on fused silica; and a-Si:H on Si(100). In the case of pure materials the shape of the acoustic pulse and the phase velocity were determined. The dispersion of the SAW phase velocity observed for the film systems was used to extract information on the film thickness, density, and transverse and longitudinal sound velocity. Models for the theoretical treatment of film systems and the calculation of dispersion curves are presented.
Fluorescence In Situ Hybridization (FISH) as an Ancillary Diagnostic Tool in the Diagnosis of Melanoma (2009)

Although the clinical and pathologic diagnosis of some melanomas is clear-cut, there are many histopathologic simulators of melanoma that pose problems. Over-diagnosis of melanoma can lead to inappropriate therapy and psychologic burdens, whereas under-diagnosis can lead to inadequate treatment of a deadly cancer. We used existing data on DNA copy number alterations in melanoma to assemble panels of fluorescence in situ hybridization (FISH) probes suitable for the analysis of paraffin-embedded tissue. Using FISH data from a training set of 301 tumors, we established a discriminatory algorithm and validated it on an independent set of 169 unequivocal nevi and melanomas as well as 27 cases with ambiguous pathology, for which we had long-term follow-up data. An algorithm-using signal counts from a combination of 4 probes targeting chromosome 6p25, 6 centromere, 6q23, and 11q13 provided the highest diagnostic discrimination. This algorithm correctly classified melanoma with 86.7% sensitivity and 95.4% specificity in the validation cohort. The test also correctly identified as melanoma all 6 of 6 cases with ambiguous pathology that later metastasized. There was a significant difference in the metastasis free survival between test-positive and negative cases with ambiguous pathology (P=0.003). Sufficient chromosomal alterations are present in melanoma that a limited panel of FISH probes can distinguish most melanomas from most nevi, providing useful diagnostic information in cases that cannot be classified reliably by current methods. As a diagnostic aid to traditional histologic evaluation, this assay can have significant clinical impact and improve classification of melanocytic neoplasms with conflicting morphologic criteria.
Distributed Key Generation for Secure Encrypted Deduplication. (2013)

Abstract. Large-scale storage systems often attempt to achieve two seemingly conflicting goals: (1) the systems need to reduce the copies of redundant data to save space, a process called deduplication; and (2) users demand encryption of their data to ensure privacy. Conventional encryption makes deduplication on ciphertexts ineffective, as it destroys data redundancy. A line of work, originated from Convergent Encryption [28], and evolved into Message Locked Encryption [12], strives to solve this problem. The latest work, DupLESS [11], proposes a server-aided architecture that provides the strongest privacy. The DupLESS architec-ture relies on a key server to help the clients generate encryption keys that result in convergent ciphertexts. In this paper, we first provide a rigorous proof of security, in the random oracle model, for the DupLESS architecture which is lacking in the original paper. Our proof shows that using additional secret, other than the data itself, for generating encryp-tion keys achieves the best possible security under current deduplication paradigm. We then introduce a distributed protocol that eliminates the need for a key server and allows less managed systems such as P2P sys-tems to enjoy the high security level. Implementation and evaluation show that the scheme is both robust and practical. 1
Phase-locked two-dimensional arrays of implant isolated vertical cavity surface emitting lasers (1990)

The fabrication and characterisation of two-dimensional phase-locked arrays of vertical cavity surface emitting lasers is reported. The three two-dimensional array structures characterised were a 2 × 3 periodic array of 10μm2 lasers, a hexagonal array and a centred hexagonal array of 5 μm hexagonal lasers. All arrays were fabricated using the same technique which was a combination of mesa etching and oxygen implantation isolation.
Contrasting roles of condensin I and II in mitotic chromosome formation (2012)

In vertebrates, two condensin complexes exist, condensin I and condensin II, which have differing but unresolved roles in organizing mitotic chromosomes. To dissect accurately the role of each complex in mitosis, we have made and studied the first vertebrate conditional knockouts of the genes encoding condensin I subunit CAP-H and condensin II subunit CAP-D3 in chicken DT40 cells. Live-cell imaging reveals highly distinct segregation defects. CAP-D3 (condensin II) knockout results in masses of chromatin-containing anaphase bridges. CAP-H (condensin I)-knockout anaphases have a more subtle defect, with chromatids showing fine chromatin fibres that are associated with failure of cytokinesis and cell death. Super-resolution microscopy reveals that condensin-I-depleted mitotic chromosomes are wider and shorter, with a diffuse chromosome scaffold, whereas condensin-II-depleted chromosomes retain a more defined scaffold, with chromosomes more stretched and seemingly lacking in axial rigidity. We conclude that condensin II is required primarily to provide rigidity by establishing an initial chromosome axis around which condensin I can arrange loops of chromatin.
The effect of the prepolymer composition of amino-hardened epoxy resins on the water sorption behavior and plasticization (1982)

The main role of the amino hydrogen bonding in the plasticization of water-penetrated epoxy resins has been tested on a diglycidyl ether of bisphenol-A (DGEBA) epoxy cured with different amounts of triethylenetetramine (TETA). Samples were characterized both by calorimetric and moisture diffusion techniques. The increased water solubilities and glass transition temperature depressions observed for the samples cured with an increased content of amino hardener were attributed to the high hydrophilic character of the amine. Theoretical models, based on the analysis of the free volume and entropy of the water saturated polymer, have been used to test the nature of the polymer-diluent interactions. The comparison between the experimentally determined and theoretical values of the wet glass transition temperatures indicates how the free volume better describes the behavior of the low amino content resins while the entropy model become effective at increasing amino contents. Moreover, the actual water solubilities have been determined by thermal cycling of water-saturated samples of different composition and used in the cited models.
Biophysical characterization of rotavirus serotypes G1, G3, and G4 (2010)

The stability of attenuated virus vaccines has traditionally been assessed by a plaque assay to measure the virus's loss of replication competency in response to a variety of environmental perturbations. Although this method provides information regarding the impact of the vaccine formulation, it involves an empirical approach to evaluate stability. Biophysical studies on the other hand have the potential to provide insight into the mechanisms of inactivation of a viral vaccine in response to a variety of stressed conditions. Herein, we have employed a variety of spectroscopic techniques (i.e., circular dichroism, fluorescence spectroscopy and dynamic light scattering) for a comprehensive examination of the thermal stability of three live-attenuated human-bovine reassortant rotavirus strains (G1, G3 and G4) in the 5-8 pH range. The spectroscopic methods employed are not specific and response changes reflect an average change over the entire virus structure. The present work, however, suggests the utility of these methods in early formulation of rotaviral vaccines due to their ability to identify regions of marginal stability over which high throughput excipient screening assays can be designed. We have further shown that these methods are sufficiently sensitive to differentiate the stability of the three homologous G-subtypes differing only in the composition of their surface antigenic proteins. The data from these spectroscopic methods are also compared to biological activity using a tissue culture viral infectivity assay. Partial correlation between the structural alterations and losses in activity are observed, further suggesting the utility of biophysical studies in early formulation studies of rotavirus vaccines.
Expression of <i>fgf</i> and <i>fgf</i> receptor genes in human breast cancer (1995)

The family of FGF growth factors is involved in several biological processes and might play an important role in tumorigenesis. We have studied the respective expression of 8 of the 9 characterized FGF genes, and of the 4 known FGF receptor genes, in a panel of 10 tumor-cell lines and 103 breast-tumor samples, using RT-PCR and Northern-blot analyses. FGF1 and FGF2 were expressed in almost all samples, while expression of FGF5, FGF6, FGF7, and FGF9 was more restricted. FGFR1, FGFR2 and FGFR4 were expressed at high levels in respectively 22%, 4% and 32% of tumors. FGFR3 expression was not detected. The transcript encoding an FGFR1 isoform with 2 immunoglobulin-like domains was the most prevalent.
COTS fibre channel network technology insertion into avionics systems (2002)

This paper provides an overview of network architecture, network building block, and network application issues involved in the insertion of Fibre Channel (FC) Commercial Off-The-Shelf (COTS) technology into avionics systems. At the network architecture level, FC supports a simple and low cost Arbitrated Loop (FC-AL) topology which is extensible to fabric switch architectures. A COTS FC testbed is described which has been constructed to characterize FC-AL performance for defined domain-specific avionics scenarios. The testbed is also being used to prototype an avionics multimedia network via integration of FC COTS network controllers and software with streaming video encoders and decoders. Based on lessons learned from the testbed activity and other FC system architecture insertion studies, a set of FC based domain extended products suitable for insertion into avionics systems is identified. Finally future activities required to continue toward a fully capable FC Avionics Multimedia Network (AMN) are described.