gebhart/patrepeval huggingface dataset:
Molecular characterization of the murine Ahr gene. Organization, promoter analysis, and chromosomal assignment. (1993)

The AH receptor is a ligand-activated transcription factor that mediates the biological effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin. The AH receptor has primary sequence homology to its dimerization partner the AH receptor nuclear translocator, and to the Drosophila proteins Sim and Per. Characterization of the gene encoding the murine AH receptor (Ahr gene) reveals that its structural organization is also conserved with respect to the sim gene, since 6 of 11 Ahr exons are spliced at homologous sites. Interestingly, little splicing homology was observed between the Ahr and per genes. The promoter of the Ahr gene is GC-rich and contains no TATA or CCAAT boxes; however, sequence analysis has shown several binding sites for the transcription factor Sp1 (GC boxes). Additionally we have identified a potential cAMP response element, AP-1 and E box sites, and two elements demonstrated in other genes to confer placenta-specific expression. Using a restriction fragment length polymorphism in exon 7 and recombinant inbred mouse lines, the Ahr gene was found to be concordant with the phenotypically defined Ahr locus, supporting the identity of these two genetic elements.
BiCMOS technology for mixed-digital, analog, and RF applications (2002)

As process technology advances, we will see SoC systems with millions of digital gates combined with RF circuits operating in the tens of GHz.
Cisplatin binding to human serum albumin: a structural study (2015)

The reaction between cisplatin and human serum albumin (HSA) was investigated by X-ray crystallography and crystal structures of the cisplatin/HSA adduct were eventually solved for the first time. Structural data unambiguously prove that cisplatin mainly binds to His105 and Met329 side chains; additional binding sites are detected at His288, Met298, and Met548 and at His535, His67 and His247.
Developing an observational form for assessing patients' mental health (1998)

Assessment is an important component of the occupational therapy process. This article details the development of an observation form that can be used to assess a patient's performance during occupational therapy treatment. The form acts as a continuous assessment record with the aim of evaluating a patient's performance over a period of time.
Characterization of serine and leucine tRNAs in an asporogenic yeast<i>Candida cylindracea</i>and evolutionary implications of genes for tRNA<sup>Ser</sup>CAG responsible for translation of a non-universal genetic code (1994)

Five serine and three leucine isoaceptor tRNAs were purified from the asporogenic yeast Candida cylindracea, in which codon CUG is translated as serine instead of leucine, and their primary structures were determined. From the wobble hypothesis, it was assumed that one of the tRNA(Leu) species (Leu1), with the anticodon CmAA, corresponded to the UUG leucine codon, and that the remaining two leucine tRNAs (Leu2 and Leu3), with the same IAG anticodon sequence would decode the CUU, CUC and CUA codons as leucine, but not the CUG codon; this was clarified by an in vitro translation experiment with C.cylindracea using synthetic mRNAs containing the CUA or CUG codons. One of the serine tRNAs (Ser1) has already been demonstrated to have the anticodon CAG and to be responsible for translation of the codon CUG in C.cylindracea. Three of the other species of tRNA(Ser) (Ser2,3 and 4), with the anticodon sequences cm5UGA, IGA and CGA, can translate all four codons in the UCN codon box, while the remaining species (Ser5), with the anticodon GCU, corresponds to AGU and AGC serine codons. The gene sequences for these five serine and three leucine tRNAs were also determined, with the finding that only tRNA(Ser)CAG (Ser1) has an intron. At least five different types of tRNA(Ser)CAG genes exist in the genome of C.cylindracea. The nucleotide sequences of the flanking regions of these tRNA(Ser)CAG genes indicated that the tRNA(Ser)CAG gene has duplicated at least three times on the genome. The existence of multiple genes for tRNA(Ser)CAG on the genome may account for the observation that codon CUG is used very frequently in C.cylindracea. All of these tRNASerCAG genes contain the CCA sequence in their 3' termini, suggesting the possibility that during their multiplication process in the evolution of the C.cylindracea genome, the tRNA(Ser)CAG molecule was integrated into DNA via reverse transcription.
Ontology-based IT pedagogical knowledge framework (2007)

Permanent Link: The attached document may provide the author&apos;s accepted version of a published work. See Citation for details of the published work.
Anti-Ebola therapies based on monoclonal antibodies: current state and challenges ahead (2015)

The 2014 Ebola outbreak, the largest recorded, took us largely unprepared, with no available vaccine or specific treatment. In this context, the World Health Organization declared that the humanitarian use of experimental therapies against Ebola Virus (EBOV) is ethical. In particular, an experimental treatment consisting of a cocktail of three monoclonal antibodies (mAbs) produced in tobacco plants and specifically directed to the EBOV glycoprotein (GP) was tested in humans, apparently with good results. Several mAbs with high affinity to the GP have been described. This review discusses our current knowledge on this topic. Particular emphasis is devoted to those mAbs that have been assayed in animal models or humans as possible therapies against Ebola. Engineering aspects and challenges for the production of anti-Ebola mAbs are also briefly discussed; current platforms for the design and production of full-length mAbs are cumbersome and costly.
Reflex changes in hindlimb and renal vascular resistance in response to distention of the isolated pulmonary arteries of the dog. (1977)

We describe a preparation that uses a constant flow, right heart bypass for perfusion of an isolated pouch of the main pulmonary arteries at controlled pressures, and show that increments in pressure in the pulmonary arterial pouch are accompanied by increases in systemic vascular resistance and in hindlimb vascular resistance. These changes are demonstrated over the whole range of 5-120 cm H2O pressure in the pulmonary arterial pouch. In contrast there are no significant changes in renal vascular resistance or heart rate. We find that changing the temperature of the perfusate in the pulmonary arterial pouch from 37 degrees C to 30 degress C is associated with a decrease in systemic vascular resistance. Furthermore, the effects of raising the pulmonary arterial pouch pressure and of cooling are abolished by cervical vagotomy. These findings suggest that there is a tonic reflex vasoconstrictor tone generated by the activity of receptors lying in or close to the walls of the pulmonary artery. These findings also suggest that the differential effects on systemic vascular resistance and renal resistance may provide one mechanism by which changes in blood volume may lead to appropriate changes in renal solute excretion.
Mitigating multi-bit soft errors in L1 caches using last-store prediction (2007)

Abstract—Recent studies suggest that the rate of spatial multi-bit soft errors will increase with future technology scaling. Unfortunately, multi-bit errors cannot be effectively mitigated with conventional techniques in L1 data caches (e.g., bit interleaving or stronger coding) due to high power and/or latency overheads. We propose the laststore predictor, a lightweight prediction mechanism that accurately determines when a cache block is written for the last time and writes the data back to the L2 cache where increased access latency permits more effective multi-bit error protection. Using a combination of commercial workloads and SPEC CPU2000 benchmarks, we show that, on average, write-back L1 data caches are 42 % vulnerable to multi-bit soft errors. Where SECDED ECC fails to mitigate multi-bit errors, our mechanism reduces the multi-bit soft-error vulnerability to 12 % on average. I.
<b>Steroids. CC.<sup>1</sup> Spectra and Stereochemistry, Part III.<sup>2</sup> Steroidal 5,6 - Epoxides</b> (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSteroids. CC.1 Spectra and Stereochemistry, Part III.2 Steroidal 5,6 - EpoxidesAlexander D. CrossCite this: J. Am. Chem. Soc. 1962, 84, 16, 3206–3207Publication Date (Print):August 1, 1962Publication History Published online1 May 2002Published inissue 1 August 1962https://pubs.acs.org/doi/10.1021/ja00875a048https://doi.org/10.1021/ja00875a048research-articleACS PublicationsRequest reuse permissionsArticle Views88Altmetric-Citations69LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Fabrication, structure, magnetic properties of highly ordered cobalt disulfide nanowire arrays (2005)

Highly ordered arrays of parallel CoS2 nanowires with a diameter of about 50 nm and a length up to about 50μm were synthesized by two electrical fields in an anodized aluminum oxide film. In this letter, fabrication, structure, magnetic properties of highly ordered magnetic cobalt disulfide nanowires arrays were studied. Also, a growth mechanism has been speculated.
Screening, Manufacturing, Photoluminescence, and Molecular Recognition of Co-Crystals: Cytosine with Dicarboxylic Acids (2010)

A workflow for screening and manufacturing co-crystals was used to produce 4:1 co-crystal of cytosine−oxalic acid dihydrate, 2:1 co-crystal of cytosine−malonic acid, and 2:1 co-crystal of cytosine−succinic acid with melting points of 270.2, 219.2, and 249.5 °C, and Ksp values of 8.21 × 10−12 m5, 4.90 × 10−5 m3, and 3.11 × 10−6 m3 in water at 25 °C, respectively. 4:1 co-crystal of cytosine−oxalic acid dihydrate crystallized in the P21/c space group. Both 2:1 co-crystal of cytosine−malonic acid and 2:1 co-crystal of cytosine−succinic acid crystallized in the P1̅ space group. Co-crystals of cytosine with dicarboxylic acids all possessed a self-assembled cyclic pattern of R22(12) forming by a pair of N−H···O hydrogen bonds within a dimeric motif of cytosine. The self-recognition pairing of cytosine here resembled the standard hydrogen bonding pattern in the Watson−Crick complementary base pairing of guanine and cytosine but without the middle N−H···N interaction. Both photoluminescence (PL) emission intensity and the solubility of co-crystals at a given temperature followed the same descending order of 2:1 co-crystal of cytosine−malonic acid > 2:1 co-crystal of cytosine−succinic acid > 4:1 co-crystal of cytosine−oxalic acid dihydrate. The weakening of the hydrogen bonding strength of 2:1 co-crystal of cytosine−malonic acid due to the angling of the interlayers might explain its lowest melting point of 219.2 °C, its highest solubility and its highest PL emission intensity.
Wideband dual-polarized omnidirectional antenna with very high isolation across 1.65&#x2013;2.7 GHz (2014)

Wideband dual polarized omni-directional antenna is proposed. The design includes concentric ring and monopole antennas, placed over a square ground plane. Both of the antennas retain 10dB return loss across the 1.65 - 2.7 GHz range. Of importance is that port isolation is 70dB across the frequency band of interest in spite of collocation of antennas. The overall antenna dimensions are 4cm × 18cm × 18cm. Radiation pattern and high isolation make it useful for simultaneous transmit (TX) / receive (RX).
European Federation of Neurological Societies/Peripheral Nerve Society Guideline on the use of skin biopsy in the diagnosis of small fiber neuropathy. Report of a joint task force of the European Fe‐deration of Neurological Societies and the Peripheral Nerve Society (2010)

Distal leg skin biopsy with quantification of the linear density of intraepidermal nerve fibers (IENF), using generally agreed upon counting rules, is a reliable and efficient technique to assess the diagnosis of SFN (Recommendation Level A). Normative reference values are available for bright-field immunohistochemistry (Recommendation Level A) but not yet for confocal immunofluorescence or the blister technique. The morphometric analysis of IENF density, either performed with bright-field or immunofluorescence microscopy, should always refer to normative values matched for age (Recommendation Level A). Newly established laboratories should undergo adequate training in a well-established skin biopsy laboratory and provide their own stratified for age and gender normative values, intra- and interobserver reliability, and interlaboratory agreement. Quality control of the procedure at all levels is mandatory (Good Practice Point). Procedures to quantify subepidermal nerve fibers and autonomic innervated structures, including erector pili muscles, and skin vessels, are under development but need to be confirmed by further studies. Sweat gland innervation can be examined using an unbiased stereologic technique recently proposed (Recommendation Level B). A reduced IENF density is associated with the risk of developing neuropathic pain (Recommendation Level B), but it does not correlate with its intensity. Serial skin biopsies might be useful for detecting early changes of IENF density, which predict the progression of neuropathy, and to assess degeneration and regeneration of IENF (Recommendation Level C). However, further studies are warranted to confirm its potential usefulness as an outcome measure in clinical practice and research. Skin biopsy has not so far been useful for identifying the etiology of SFN. Finally, we emphasize that 3-mm skin biopsy at the ankle is a safe procedure based on the experience of 10 laboratories reporting absence of serious side effects in approximately 35,000 biopsies and a mere 0.19% incidence of non-serious side effects in about 15 years of practice (Good Practice Point).
Chemical Composition of Redwood Bark (1944)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemical Composition of Redwood BarkH. F. Lewis, F. E. Brauns, M. A. Buchanan, and Ervin F. KurthCite this: Ind. Eng. Chem. 1944, 36, 8, 759–764Publication Date (Print):August 1, 1944Publication History Published online1 May 2002Published inissue 1 August 1944https://pubs.acs.org/doi/10.1021/ie50416a022https://doi.org/10.1021/ie50416a022research-articleACS PublicationsRequest reuse permissionsArticle Views151Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Immobilization and Ammonia Removal of Photosynthetic Bacteria (2012)

The photosynthetic bacteria have been widely used in improving the water environment, especially for pollutant purification. A photosynthetic bacterium was isolated from fish pond sludge using various methods. The bacterium is rod-shaped and slightly curved, and they reproduce by budding. It grew anaerobically when exposed to light and aerobically in darkness. Based on electron microscopy, utilization of carbon sources and amino acids, and factors required for growth, the bacterium is identified as Rhodopseudomonas palustris. The R. palustris was immobilized using different carriers to increase its concentration and its targeted use. The results show that immobilization of the bacteria stabilized the ammonia removal and protected the bacteria from predation by plankton. The method is also easy to use and prolonged the purification effect in the reactor. The immobilized microorganisms are 30%–40% more effective than free bacteria in removing ammonia.
[Cerebral magnetic resonance imaging in the neonatal period. Initial results]. (1991)

The place of neonatal cerebral MRI and its specific contribution compared with conventional imaging techniques were evaluated in 36 patients. The difficulties specific to the patient population studied met during this preliminary period are described, with their local solutions. A preliminary evaluation of the diagnostic and prognostic value of MRI according to the disease state and gestational age is presented. The specific contribution of MRI compared with transfontanellar ultrasonography and CT scan is discussed.
The operational characteristics of a stopped-flow system for ESR studies (1973)

A stopped-flow system was designed which allows precise control of flow variables during chemical generation of free radical species in the cavity of an ESR spectrometer. This equipment is applicable to both continuous and stopped-flow studies. It may be used to determine the kinetics of disappearance of short-lived intermediates with lifetimes in the millisecond range. The capability for the generation of accurate kinetic data is provided by the usage of rapid-action solenoid valves. A method for measuring their response times is described. Other features include components for oxygen and temperature measurement and an automated system for triggering repetitive kinetic experiments in conjunction with signal-averaging techniques. The advantages and improvements of this stopped-flow technique over previous such methods are discussed.
Respirator Leak Detection by Ultrafine Aerosols: A Predictive Model and Experimental Study (1993)

The leak performance of half-mask, maintenance-free respirators was studied theoretically and experimentally. A predictive model for the theoretical protection factor and leakage flow has been developed that uses the equation of particle conservation inside and outside the respirator. An experimental study was conducted using NaCl particles of 10 nm in diameter and a condensation nucleus counter as the particle detector. A respirator fitted with controlled leak holes of 20–3000 μm in diameter was tested at steady flow rates of 10, 32, and 100 L/min. Results showed that the aerosol penetration into a respirator was strongly influenced by the filter efficiency, leak hole size, and flow rate through the respirator. The results are in good agreement with theory, but some discrepancy has been noted at lower flow rates and smaller leak hole sizes. For the dust/mist respirators, the experimental protection factor for ultrafine 0.01-μm NaCl particles ranged from 3145 to as low as 3. For the high efficiency dust/mist/fume/radionuclide respirator, a protection factor as high as 4.1 × 109 was measured on the ultrafine aerosol. For all respirators, the protection factors decreased rapidly with increasing leak hole size and increased as flow rate decreased. The result of the study shows that with ultrafine aerosols, the particle penetration through the respirator filter can be reduced to a small, and in some instances, negligible value. The resulting protection factor is then due almost entirely to aerosol penetration through the leak hole. The ultrafine aerosol test can thus be used to study the characteristics of the face seal leakage, without the complication of the aerosol penetration through the respirator filter.
Diminished Hepatic Response to Fasting/Refeeding and Liver X Receptor Agonists in Mice with Selective Deficiency of Sterol Regulatory Element-binding Protein-1c (2002)

Two treatments, fasting/refeeding and administration of liver X receptor (LXR) agonists, elevate the mRNA for sterol regulatory element-binding protein-1c (SREBP-1c) and enhance lipid synthesis in liver. These treatments do not affect the mRNA for SREBP-1a, an alternative transcript from the same gene. Through homologous recombination, we eliminated the exon encoding SREBP-1c from the mouse genome, leaving the SREBP-1a transcript intact. On a normal diet, livers of SREBP-1c(-/-) mice manifested reductions in multiple mRNAs encoding enzymes of fatty acid and triglyceride synthesis, including acetyl-CoA carboxylase (ACC) and fatty acid synthase (FAS). In contrast, SREBP-1c(-/-) livers showed a compensatory increase in hepatic SREBP-2 mRNA, accompanied by increased mRNA levels for cholesterol biosynthetic enzymes. In fasted/refed animals, ACC and FAS mRNAs rose, but not to the same extent as in wild-type livers. The refeeding-induced increase in SREBP-1c(-/-) mice was greater than in mice lacking SREBP cleavage-activating protein (SCAP), in which all nuclear SREBPs are absent. Thus, SREBP-2 and/or SREBP-1a can substitute partially for SREBP-1c in permitting an insulin-mediated increase in ACC and FAS mRNAs. In contrast, mRNAs for several other lipogenic enzymes (glucose-6-phosphate dehydrogenase, malic enzyme, glycerol-3-phosphate acyltransferase, and stearoyl-CoA desaturase-1) showed a complete failure of the normal inductive response to refeeding, indicating specific reliance on SREBP-1c. Moreover, these mRNAs, as well as multiple other lipogenic mRNAs, showed a markedly blunted response to the LXR agonist T090137, indicating an essential role of SREBP-1c in the LXR response.
Flowcharting With the ANSI Standard: A Tutorial (1970)

article Free Access Share on Flowcharting With the ANSI Standard: A Tutorial Author: Ned Chapin InfoSci Inc., Menlo Park, California InfoSci Inc., Menlo Park, CaliforniaView Profile Authors Info & Claims ACM Computing SurveysVolume 2Issue 2June 1970 pp 119–146https://doi.org/10.1145/356566.356570Published:01 June 1970Publication History 26citation3,336DownloadsMetricsTotal Citations26Total Downloads3,336Last 12 Months805Last 6 weeks217 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Catalytic one-pot synthesis of N-phenyl alkyl amides from alkene and aniline in the presence of cobalt on charcoal under carbon monoxideElectronic supplementary information (ESI) available: characterization of new compounds. See http://www.rsc.org/suppdata/cc/b2/b201708c/ (2002)

N-Phenyl alkyl amides were synthesized by the cobalt on charcoal-catalyzed one-pot reaction of alkene and aniline under carbon monoxide; this is the first heterogeneous catalytic formation of N-phenyl alkyl amides.
The Role of Diffusion-Weighted Imaging and the Apparent Diffusion Coefficient (ADC) Values for Breast Tumors (2007)

DWI has a high sensitivity for detecting breast tumors, and especially for detecting malignant breast tumors. DWI was an effective imaging technique for detecting breast lesions, as compared to using the T1- and T2-weighted images.