gebhart/patrepeval huggingface dataset:
This Month in Adult Urology (2017)

No AccessJournal of UrologyThis Month in Adult Urology1 Feb 2018This Month in Adult Urology Joseph A. Smith Joseph A. SmithJoseph A. Smith More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2017.10.036AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail References 1 : Delayed reconstruction of bulbar urethral strictures is associated with multiple interventions, longer strictures and more complex repairs. J Urol2018; 199: 515. Link, Google Scholar 2 : Do transurethral treatments increase the complexity of urethral strictures?. J Urol2018; 199: 508. Link, Google Scholar 3 : Reasons for seeking clinical care for lower urinary tract symptoms: a mixed methods study. J Urol2018; 199: 528. Link, Google Scholar 4 : Burden of multiple chronic conditions among patients with urological cancer. J Urol2018; 199: 543. Link, Google Scholar 5 : Focal therapy eligibility determined by magnetic resonance imaging/ultrasound fusion biopsy. J Urol2018; 199: 453. Link, Google Scholar 6 : Depressive symptoms and low sexual desire after radical prostatectomy: early and long-term outcomes in a real-life setting. J Urol2018; 199: 474. Link, Google Scholar 7 : Active surveillance for low risk nonmuscle invasive bladder cancer: a confirmatory and resource consumption study from the BIAS project. J Urol2018; 199: 401. Link, Google Scholar 8 : Sleep problems are associated with development and progression of lower urinary tract symptoms: results from REDUCE. J Urol2018; 199: 536. Link, Google Scholar 9 : Local tumor bed recurrence following partial nephrectomy in patients with small renal masses. J Urol2018; 199: 393. Link, Google Scholar 10 : Prevalence and management of incidental small testicular masses discovered on ultrasonographic evaluation of male infertility. J Urol2018; 199: 481. Link, Google Scholar 11 : Genomic scores are independent of disease volume in men with favorable risk prostate cancer: implications for choosing men for active surveillance. J Urol2018; 199: 438. Link, Google Scholar 12 : Impact of 5α-reductase inhibitors on disease reclassification among men on active surveillance for localized prostate cancer with favorable features. J Urol2018; 199: 445. Link, Google Scholar © 2018 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 199Issue 2February 2018Page: 315-317 Advertisement Copyright & Permissions© 2018 by American Urological Association Education and Research, Inc.MetricsAuthor Information Joseph A. Smith More articles by this author Expand All Advertisement PDF downloadLoading ...
Microbiology and Technology of Fermented Foods (2006)

Chapter 1: Introduction. Chapter 2: Microorganisms. Chapter 3: Cultures. Chapter 4: Cultured Dairy Products. Chapter 5: Cheese. Chapter 6: Meat. Chapter 7: Vegetables. Chapter 8: Bread. Chapter 9: Beer. Chapter 10: Wine. Chapter 11: Vinegar. Chapter 12: Fungal
Atheroprotective Effects of Alum Are Associated With Capture of Oxidized LDL Antigens and Activation of Regulatory T Cells (2009)

The immune system represents a promising novel target for prevention of atherosclerosis. Several pilot vaccines that reduce atherosclerosis in experimental animals have been developed. The aluminum hydroxide adjuvant Alum has been shown to have antiatherogenic properties in itself, suggesting that it may be a suitable adjuvant in possible future atherosclerosis vaccines. To characterize the immune pathways mediating this protection, we treated wild-type C57BL/6 and Apoe(-)(/)(-) mice with Alum or PBS. Analyses of splenocytes isolated from 12-week-old mice demonstrated that Alum increased the presence of CD4(+)CD25(+)FoxP3(+) regulatory T cells and downregulated the expression of T cell activation markers CD28 and ICOS in Apoe(-)(/)(-) mice but not in C57BL/6 wild-type mice. A similar immunosuppressive phenotype was found also in 25-week-old Apoe(-)(/)(-) mice and was associated with reduced atherosclerosis. Alum precipitates recovered from the injection site of Apoe(-)(/)(-) mice contained antigens derived from oxidized LDL. These findings demonstrate that treatment of Apoe(-)(/)(-) mice with Alum results in an increase of regulatory T cells and suggest that these are activated by tolerogenic antigen-presenting cells presenting oxidized LDL antigens. Our findings provide improved mechanistic understanding of the atheroprotective properties of aluminum hydroxide adjuvants but also point to the importance of determining if hypercholesterolemia may compromise the efficacy of Alum-containing vaccines used clinically today.
Glucocorticoid-induced inhibition of T cell growth factor production. I. The effect on mitogen-induced lymphocyte proliferation. (1979)

Although it has been clearly established that glucocorticoids inhibit mitogen- or antigen-induced lymphocyte proliferation, the mechanism underlying this effect has remained ill-defined. Recently, it has become evident that T cell proliferation is mediated by a soluble T cell growth factor (TCGF) released by mitogen/antigen stimulated T cells. Therefore it seemed probable that the inhibitory effects of glucocorticoids were manifested either at the level of TCGF production or at the level of the activated T lymphocyte. We found that differentiated cytolytic T lymphocytes harvested from TCGF-dependent long-term culture were only mildly sensitive to inhibitory effects (25 to 30% inhibition) of glucocorticoids as measured by decreased cellular proliferation and the incorporation of tritiated thymidine. The degree of inhibition observed was most probably mediated through glucocorticoid receptors in that the half maximal inhibitory glucocorticoid concentration correlated with half-maximal glucocorticoid receptor saturation. In contrast, we found that mitogen-induced TCGF production and T cell proliferation were completely inhibited by pharmacologic concentrations of dexamethasone (10 -6 M). Finally, the TCGF supplementation of mitogen-stimulated cultures treated with maximal inhibitory concentrations of dexamethasone resulted in complete amelioration of glucocorticoid suppression. These results indicate that a major mechanism of glucocorticoid-mediated immunosuppression may occur at the level of the TCGF-producing cell, resulting in the control of clonal expansion of activated T cells via inhibition of TCGF production.
Channel adaptive power allocation and pilot optimization for OFDM systems (2012)

An adaptive resource allocation scheme is designed for OFDM that maximizes the average transmission rate by adapting the power of the data symbols while optimizing the pilot symbol spacing and power. Assuming imperfect channel state information (CSI) at the transmitter, the exact solution obtained for optimum power loading across data subcarriers can not be expressed in terms of elementary functions. A useful approximation, that has the simple form of a water-filling function, is derived for determining the optimum power loading function that is based on imperfect CSI. The merits of the proposed adaptive resource allocation schemes are corroborated by numerical results.
<title>GRAMS: a distributed multimedia service system</title> (1994)

This paper is on the design and implementation of GRAMS (Gopher-style Real-time ATM Multimedia Services), a multimedia system designed for a star configuration ATM LAN with the central server providing multimedia services to multiple users in real-time. It is also the initial step towards and the essential part of a distributed multimedia system over larger area networks.
Q-switching of semiconductor lasers (1977)

A scheme for <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Q</tex> -switching semiconductor lasers is proposed and analyzed. The method is based upon electrooptic switching of the Bragg reflectivity of the grating reflectors forming the cavity of the semiconductor laser. The basic configuration, the operating principles, and the dynamic behavior of these lasers are described. Although the maximum initial inversion in this laser system is limited to a rather low value, the peak output power is found to be higher than the value usually obtained in a CW GaAs double-heterostructure (DH) laser by two orders of magnitude. A pulsewidth shorter than 100 ps is shown to be obtainable.
ChemInform Abstract: D‐D SPECTRA OF TITANIUM(II) AND VANADIUM(II) IONS DOPED INTO A SODIUM CHLORIDE HOST LATTICE (1979)

Abstract Die Präparation der dotierten Kristalle erfolgt bei 900‐950°C, wobei wegen der Zers.‐Tendenz von TiCl 2 und VCl 2 die Ionen in situ, z.B. gemäß Reaktion A, erzeugt werden.
Clinical Trials: IL-12 Deaths: Explanation and a Puzzle (1995)

Researchers investigating toxic reactions that killed two patients in a trial of interleukin-12 earlier this year have reached a surprising conclusion: The drug is highly toxic if it is given in multiple high doses, but those effects can be avoided if the multiple doses are preceded by a single dose followed by a rest period. The initial dose apparently imprints a memory on the immune system, but the mechanism is unclear.
A high power microwave zoom antenna with metal plate lenses (2014)

Metal plate lens antennas were designed and constructed for a high power microwave zoom antenna concept comprising a horn feed antenna and two metal plate lenses. Good agreement was found between experiment and simulation. This antenna provides true zoom capability in the TEM mode with continuously variable diameter pencil beam output and approximately 10% bandwidth.
<i>In situ</i> generation of Fmoc‐amino acid chlorides using <i>bis</i>‐(trichloromethyl)carbonate and its utilization for difficult couplings in solid‐phase peptide synthesis (1999)

This paper reports procedures for the straightforward in situ generation of Fmoc-amino acid chlorides using bis-(trichloromethyl)carbonate (BTC) and their utilization for difficult couplings during solid-phase peptide synthesis. The BTC-mediated coupling of all Fmoc-protected proteinogenic amino acids to a large variety of N-alkylated amino acid-peptidyl-resin was studied. The majority of the couplings proceeded with quantitative conversion and without racemization. The utilization of BTC-mediated coupling for facile solid-phase synthesis of backbone cyclic peptides is presented.
Repeated recycling of corrugated containers and its effect on strength properties (1975)

This study investigated the effects of repeated recycling on the strength and performance of paperboard and corrugated fiberboard containers. In general, the strength and performance were lowered when 100% recycled fiber was used. The greatest loss in strength occured between the virgin material and the first recycle, rather than between subsequent recycles. Repeated recycling caused poorer drainage on the foudrinier paper machine and lowered runnability of the corrugating medium. Scoreline cracking was more function of material moisture content than of recycling.
The Menderes Massif of western Turkey and the Cycladic Massif in the Aegean—do they really correlate? (1999)

Based on lithostratigraphic comparisons the Menderes Massif has been correlated with the Cycladic Massif, thereby implying that the eastern Mediterranean consists of a narrow pre-Alpine basement belt which is laterally continuous over a long distance and which experienced a similar Alpine orogenic history. Our work indicates that the architecture, the age of basement and the pre-Alpine and Alpine tectonometamorphic history of both massifs differ fundamentally from each other. The Menderes Massif consists of remnants of the Cycladic Massif which overly an exotic unit, the Menderes nappes. Both massifs do not represent lateral continuations which has implications for palaeogeographic reconstructions.
Automatic Restoration Algorithms for 35 mm Film (1999)

Videre: Journal of Computer Vision Research (ISSN 1089-2788) is a quarterly journal published electronically on the Internet by The MIT Press, Cambridge, Massachusetts, 02142. Subscriptions and address changes should be addressed to MIT Press Journals, Five Cambridge Center, Cambridge, MA 02142; phone: (617) 253-2889; fax: (617) 577-1545; e-mail: journals-orders@mit.edu. Subscription rates are: Individuals $30.00, Institutions $125.00. Canadians add additional 7% GST. Prices subject to change without notice.
Prevalence of Tension Pneumothorax in Fatally Wounded Combat Casualties (2006)

Tension pneumothorax was the cause of death in 3 to 4% of fatally wounded combat casualties. Some may be temporarily helped by battlefield thoracentesis.
Metabolic flux analysis for recombinant protein production by <i>Pichia pastoris</i> using dual carbon sources: Effects of methanol feeding rate (2009)

The intracellular metabolic fluxes through the central carbon pathways in the bioprocess for recombinant human erythropoietin (rHuEPO) production by Pichia pastoris (Mut(+)) were calculated to investigate the metabolic effects of dual carbon sources (methanol/sorbitol) and the methanol feed rate, and to obtain a deeper understanding of the regulatory circuitry of P. pastoris, using the established stoichiometry-based model containing 102 metabolites and 141 reaction fluxes. Four fed-batch operations with (MS-) and without (M-) sorbitol were performed at three different constant specific growth rates (h(-1)), and denoted as M-0.03, MS-0.02, MS-0.03, and MS-0.04. Considering the methanol consumption pathway, the M-0.03 and MS-0.02 conditions produced similar effects and had >85% of formaldehyde flux towards the assimilatory pathway. In contrast, the use of the dual carbon source condition generated a shift in metabolism towards the dissimilatory pathway that corresponded to the shift in dilution rate from MS-0.03 to MS-0.04, indicating that the methanol feed exceeded the metabolic requirements at the higher micro(0). Comparing M-0.03 and MS-0.03 conditions, which had the same methanol feeding rates, sorbitol addition increased the rHuEPO synthetic flux 4.4-fold. The glycolysis, gluconeogenesis, and PPP pathways worked uninterruptedly only at MS-0.02 condition. PPP and TCA cycles worked with the highest disturbances at MS-0.04 condition, which shows the stress of increased feeding rates of methanol on cell metabolism.
Metabolic engineering for 5-aminolevulinic acid production by Escherichia coli carrying Rhodobacter sphaeroides hemA (2002)

Engineered E. coli strains were constructed to carry the Rhodobacter sphaeroides hemA gene. Succinate, IPTG, and glucose concentration, and IPTG addition time were studied for the optimization of Aminolevulinate synthase production using one way, one-at-a-time, and 2 4 full factorial design in E. coli MG1655/pTrc99A-hemA and AFP111/pTrc99A-hemA. Aminolevulinate synthase activities of 293.6 mU/mg protein and 140.4 mU/mg protein were obtained in MG1655/pTrc99A-hemA and AFP111/pTrc99A-hemA, respectively, under optimized conditions: 3.0-5.0 g/L succinate and 0.05mM IPTG added initially. Fed-batch fermentations with media containing either tryptone or NH4Cl as nitrogen source in E. coli MG1655/pTrc99A-hemA and CGSC4676/pTrc99A-hemA provided with up to 4.0 g/L 5-aminolevulinic acid and 0.5 g/L aminoacetone. ALA specific productivities of 0.07 g/g dry cell h or 0.12 g/g dry cell h were obtained in fermentations with media containing tryptone or NH4Cl, respectively.
Epithelialization of a synthetic polymer in the feline cornea: a preliminary study. (2000)

A perfluoropolyether-based polymer coated with collagen I was implanted in the feline cornea and supported epithelial growth that showed signs of persistent adhesion, both clinically and histologically. This polymer shows potential for ophthalmic applications that require sustained epithelialization.
Design of a Pressure Sensitive Floor for Multimodal Sensing (2006)

Visualization and knowledge of detailed pressure information can play a vital role in multimodal sensing of human movement. We have designed a high-resolution pressure sensing floor prototype with a sensor density of one sensor per square centimeter that can provide real-time information about the location of the performer on the floor as well as the amount of pressure being exerted on the floor. Hardware and software have been developed for detecting, collecting, transmitting and rendering a graphical representation of the pressure data gathered from the sensors. This prototype can be easily reconfigured to cover large floor areas, and integrates closely with video, audio and motion-based sensing technologies to facilitate robust multimodal sensing. In our demonstrations, we show that the system accurately captures and transmits pressure information, and we illustrate how this forms a basis for a variety of applications including use in rehabilitation, virtual reality, entertainment, and children activity centers.
High-frequency stimulation of the globus pallidus for the treatment of Parkinson's disease (1997)

Long-term treatment of Parkinson's disease (PD) with levodopa is complicated by the development of motor fluctuations and dyskinesias. Posteroventral pallidotomy can improve tremor, bradykinesia, rigidity, and dyskinesias in PD. We performed chronic stimulation of the globus pallidus (CSGP) to duplicate the positive results of pallidotomy with reduced risk of permanent neurologic deficit in patients with advanced PD. The lead for CSGP was stereotactically implanted with the aid of microelectrode recordings in the globus pallidus pars interna. An electrical pulse generator was implanted in the subclavicular region. Stimulation settings were adjusted by computer. Five PD patients (four men, one woman) with disabling symptoms were enrolled. Three of the patients had bilateral implants. At 3 months following the last implant, four patients rated themselves as markedly improved, and one patient was moderately improved. The amount of time in the "on" state increased from 21% at baseline to 65% at 3-month follow-up (p < 0.05). There was a significant improvement in all subscales of the UPDRS (p < 0.05). One patient had an asymptomatic intracranial bleed, one patient had transient hemiparesis during surgery with stimulation, and one patient required surgical repositioning of the lead. Adverse effects caused by stimulation were minimal. CSGP is a safe and effective procedure in PD patients with motor fluctuations and dyskinesias.
Alternative Splicing of Exon 14 Determines Nuclear or Cytoplasmic Localisation of FMR1 Protein Isoforms (1996)

Impaired expression of the FMR1 gene is responsible for the fragile X mental retardation syndrome. The FMR1 gene encodes a cytoplasmic protein with RNA-binding properties. Its complex alternative splicing leads to several isoforms, whose abundance and specific functions in the cell are not known. We have cloned in expression vectors, cDNAs corresponding to several isoforms. Western blot comparison of the pattern of endogenous FMR1 proteins with these transfected isoforms allowed the tentative identification of the major endogenous isoform as ISO 7 and of a minor band as an isoform lacking exon 14 sequences (ISO 6 or ISO 12), while some other isoforms (ISO 4, ISO 5) were not expressed at detectable levels. Surprisingly, in immunofluorescence studies, the transfected splice variants that exclude exon 14 sequences (and have alternate C-terminal regions) were shown to be nuclear. Such differential localisation was however not seen in subcellular fractionation studies. Analysis of various deletion mutants suggests the presence of a cytoplasmic retention domain encoded in exon 14 and of a nuclear association domain encoded within the first eight exons that appear however to lack a typical nuclear localisation signal.
Angiostatin overexpression in Morris hepatoma results in decreased tumor growth but increased perfusion and vascularization. (2006)

hANG expression leads to inhibition of tumor growth, increased apoptosis, and changes in the expression of multiple genes involved in stress reactions, signal transduction, and apoptosis, which indicates a multifactorial reaction of tumors. An enhanced microvessel density is seen as part of these reactions and is associated with increased perfusion as measured by PET.
Using cache optimizing compiler for managing software cache on distributed shared memory system (2002)

On a distributed shared memory (DSM) system, the optimization of memory access is very important for achieving good performance. The authors propose an optimizing compiler which controls a software cache system implemented on a DSM. The software cache consists of a static part related to the compiler and a dynamic part related to cache-managing runtime routines. The compiler controls the static part of the software cache by using information from static analysis. For applications whose behavior can only be dynamically determined, the compiler uses the dynamic part of the software cache. They also propose the application of RISC-oriented optimization techniques to parallel applications on their software cache system. They evaluate the efficiency of the compiler and RISC-oriented optimization techniques on the CM-5 distributed parallel machine. The results show that the compiler and the optimizations considerably improve the performance of basic linear algebra routines: matrix multiplication, Cholesky decomposition and Gaussian elimination.
Consideration of node failures in network-reliability calculation (1996)

Terminal-pair reliability is a common measure of telecommunication network reliability, and many algorithms for calculating it have been published. Most such algorithms presume perfect nodes; although some have presumed imperfect nodes. This paper presents a very simple, uncomplicated way to account for imperfect nodes.
In Silico Genetics: Identification of a Functional Element Regulating <i>H2</i> - <i>E</i> α Gene Expression (2004)

Computational tools can markedly accelerate the rate at which murine genetic models can be analyzed. We developed a computational method for mapping phenotypic traits that vary among inbred strains onto haplotypic blocks. This method correctly predicted the genetic basis for strain-specific differences in several biologically important traits. It was also used to identify an allele-specific functional genomic element regulating H2-Ealpha gene expression. This functional element, which contained the binding sites for YY1 and a second transcription factor that is probably serum response factor, is located within the first intron of the H2-Ealpha gene. This computational method will greatly improve our ability to identify the genetic basis for a variety of phenotypic traits, ranging from qualitative trait information to quantitative gene expression data, which vary among inbred mouse strains.
Ultrahigh-power-bandwidth product and nonlinear photoconductance performances of low-temperature-grown GaAs-based metal-semiconductor-metal traveling-wave photodetectors (2002)

Maximum-output-power and bandwidth performances are usually two tradeoff parameters in the design of high-speed photodetectors (PDs). In this paper, we report record high-peak output voltage (/spl sim/ 30 V) together with ultrahigh-speed performance (1.8 ps, 190 GHz) observed in low-temperature-grown GaAs (LTG-GaAs)-based metal-semiconductor-metal (MSM) traveling-wave photodetectors (TWPDs) at a wavelength of 800 nm. Ultrahigh-peak output power and ultrahigh-electrical bandwidth performances were achieved due to superior MSM microwave guiding structure, short carrier trapping time, and the capability to take high bias voltage (/spl sim/ 30 V) with a LTG-GaAs layer. Under such a high bias voltage, a significant nonlinear photocurrent increase with the bias voltage was observed. The nonlinear photoconductance and ultrahigh-output power-bandwidth performances opens a new way in the application of high-performance optoelectronic mixers and photomixer devices.