gebhart/patrepeval huggingface dataset:
Processing of antibodies bound to B-cell lymphomas and other hematological malignancies. (1996)

In an attempt to recognize general patterns in the processing of Abs (antibodies) bound to the surface of tumor cells, eight monoclonal antibodies were tested on 10 hematological malignancies of various histological types. The results were compared with previous findings obtained with carcinomas, melanomas, and gliomas, using some of the same antibodies. The data demonstrated that some B-cell lymphomas appear to be unusual in that Abs were unable to bind to them irreversibly; except for those Abs that were rapidly internalized, none of the Abs tested was able to bind irreversibly to the B-cell lymphomas Raji or RL. In contrast, most Abs bound irreversibly to the tumors of other histological types, including other hematological tumors. Irreversible Ab binding to B-cell lymphomas was achieved by cross-linking the Abs on the cell surface. Such differences between cell lines may be due to differences in the supramolecular structure of the surface membrane, which affect the frequency or stability of bivalent Ab binding. The Ab binding interaction could not be described in terms of "functional affinity." These results may lead to improvements in the use of Abs for tumor immunotherapy and for other purposes.
Simulating distributed elements with asymptotic waveform evaluation (2003)

A novel method for simulating distributed elements is described. The asymptotic waveform evaluation (AWE) technique is used to compute a low-order approximation to the admittance matrix for a system of coupled lossy lines. The Y-matrix can serve as a macromodel for the lines, so that they can be simulated together with arbitrary (nonlinear) terminations. A major advantage of the proposed method is that it allows general distributed elements to be simulated in the time domain without using computationally expensive lumped models or numerical inverse transform techniques. In addition, a novel frequency-shifting technique is introduced which can lead to more accurate AWE approximations.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
ACTIVATION OF NUCLERA FACTOR-^|^kappa; B AND CONTROL OF THE EXPRESSION OF CELL ADHESION MOLECULES IN HUMAN PROSTATE CANCER CELLS (1996)

These observations indicate that while the signaling pathway to NF kappa B is intact, it is not directed to induction of its target CAM genes. It is possible that other transcription factors might be involved in these cells and that they might to be constitutively stimulated during the carcinogenesis of prostate cancer.
A differential flatness based model predictive control approach (2012)

In this contribution a novel extension to model predictive control for a certain class of input affine nonlinear systems is proposed, which satisfy the property of differential flatness and are of minimum phase. By feedforward linearization of the nonlinear system via a flatness based control law, the problem of nonlinear model predictive control is reduced to the well known linear model predictive control. This results in a considerable reduction in computational effort. Input constraints are considered via a nonlinear transformation and the cost functional can be minimized by usage of a standard quadratic programming algorithm. A simulation example is given to demonstrate the usefulness of this new strategy.
CD8 T Cells Recruited Early in Mouse Polyomavirus Infection Undergo Exhaustion (2012)

Repetitive Ag encounter, coupled with dynamic changes in Ag density and inflammation, imparts phenotypic and functional heterogeneity to memory virus-specific CD8 T cells in persistently infected hosts. For herpesvirus infections, which cycle between latency and reactivation, recent studies demonstrate that virus-specific T cell memory is predominantly derived from naive precursors recruited during acute infection. Whether functional memory T cells to viruses that persist in a nonlatent, low-level infectious state (smoldering infection) originate from acute infection-recruited naive T cells is not known. Using mouse polyomavirus (MPyV) infection, we previously showed that virus-specific CD8 T cells in persistently infected mice are stably maintained and functionally competent; however, a sizeable fraction of these memory T cells are short-lived. Further, we found that naive anti-MPyV CD8 T cells are primed de novo during persistent infection and contribute to maintenance of the virus-specific CD8 T cell population and its phenotypic heterogeneity. Using a new MPyV-specific TCR-transgenic system, we now demonstrate that virus-specific CD8 T cells recruited during persistent infection possess multicytokine effector function, have strong replication potential, express a phenotype profile indicative of authentic memory capability, and are stably maintained. In contrast, CD8 T cells recruited early in MPyV infection express phenotypic and functional attributes of clonal exhaustion, including attrition from the memory pool. These findings indicate that naive virus-specific CD8 T cells recruited during persistent infection contribute to preservation of functional memory against a smoldering viral infection.
The Synthesis of DL-Canaline, DL-Canavanine and Related Compounds<sup>1</sup> (1957)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Synthesis of DL-Canaline, DL-Canavanine and Related Compounds1David D. Nyberg and Bert E. ChristensenCite this: J. Am. Chem. Soc. 1957, 79, 5, 1222–1226Publication Date (Print):March 1, 1957Publication History Published online1 May 2002Published inissue 1 March 1957https://pubs.acs.org/doi/10.1021/ja01562a050https://doi.org/10.1021/ja01562a050research-articleACS PublicationsRequest reuse permissionsArticle Views186Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Visual Important-Driven Interactive Rendering of 3D Geometry Model over Lossy WLAN (2011)

In this paper, we propose a visual important-driven interactive rendering method for 3D model over 802.11 WLAN for overcoming the shortcomings of wireless network’s narrow bandwidth, high transmission error rates and mobile devices’ low power supply. This paper first proposes an efficient simplification method based on an improved visual important region detection technique. Then, we develop an efficient hybrid FEC and MAC-Lite model transmission protocol which will transmit the model data by their importance respectively. Finally, we propose a real-time interactive rendering method by an efficient model coding. Experimental results demonstrate that we can obtain better rendering result among lossy environment and gain real-time interactive rendering result.
Computational Fluid Dynamics Modeling of Steady‐State Momentum and Mass Transport in a Bioreactor for Cartilage Tissue Engineering (2002)

Computational fluid dynamics (CFD) models to quantify momentum and mass transport under conditions of tissue growth will aid bioreactor design for development of tissue-engineered cartilage constructs. Fluent CFD models are used to calculate flow fields, shear stresses, and oxygen profiles around nonporous constructs simulating cartilage development in our concentric cylinder bioreactor. The shear stress distribution ranges from 1.5 to 12 dyn/cm(2) across the construct surfaces exposed to fluid flow and varies little with the relative number or placement of constructs in the bioreactor. Approximately 80% of the construct surface exposed to flow experiences shear stresses between 1.5 and 4 dyn/cm(2), validating the assumption that the concentric cylinder bioreactor provides a relatively homogeneous hydrodynamic environment for construct growth. Species mass transport modeling for oxygen demonstrates that fluid-phase oxygen transport to constructs is uniform. Some O(2) depletion near the down stream edge of constructs is noted with minimum pO(2) values near the constructs of 35 mmHg (23% O(2) saturation). These values are above oxygen concentrations in cartilage in vivo, suggesting that bioreactor oxygen concentrations likely do not affect chondrocyte growth. Scale-up studies demonstrate the utility and flexibility of CFD models to design and characterize bioreactors for growth of tissue-engineered cartilage.
Tissue Engineered Bands of Büngner for Accelerated Motor and Sensory Axonal Outgrowth (2020)

Following peripheral nerve injury comprising a segmental defect, the extent of axon regeneration decreases precipitously with increasing gap length. Schwann cells play a key role in driving axon re-growth by forming aligned tubular guidance structures called bands of Büngner, which readily occurs in distal nerve segments as well as within autografts - currently the most reliable clinically-available bridging strategy. However, host Schwann cells generally fail to infiltrate large-gap acellular scaffolds, resulting in markedly inferior outcomes and motivating the development of next-generation bridging strategies capable of fully exploiting the inherent pro-regenerative capability of Schwann cells. We sought to create preformed, implantable Schwann cell-laden microtissue that emulates the anisotropic structure and function of naturally-occurring bands of Büngner. Accordingly, we developed a biofabrication scheme leveraging biomaterial-induced self-assembly of dissociated rat primary Schwann cells into dense, fiber-like three-dimensional bundles of Schwann cells and extracellular matrix within hydrogel micro-columns. This engineered microtissue was found to be biomimetic of morphological and phenotypic features of endogenous bands of Büngner, and also demonstrated 8 and 2× faster rates of axonal extension <i>in vitro</i> from primary rat spinal motor neurons and dorsal root ganglion sensory neurons, respectively, compared to 3D matrix-only controls or planar Schwann cells. To our knowledge, this is the first report of accelerated motor axon outgrowth using aligned Schwann cell constructs. For translational considerations, this microtissue was also fabricated using human gingiva-derived Schwann cells as an easily accessible autologous cell source. These results demonstrate the first tissue engineered bands of Büngner (TE-BoBs) comprised of dense three-dimensional bundles of longitudinally aligned Schwann cells that are readily scalable as implantable grafts to accelerate axon regeneration across long segmental nerve defects.
Improved results of primary total hip replacement (2010)

The risk of revision decreased during the study period, due to fewer cases of aseptic loosening of prosthetic components. The best results were obtained with the use of cemented prostheses. Prevention of dislocation and infection should be a major goal in the future, as revision due to these causes increased during the study period.
ACK delay control for improving TCP throughput over satellite links (2005)

TCP has been proved to work well in a variety of situations. However, in links of large bandwidth products, e.g., satellite links, TCP might underutilize the link and degrade the reliability. A number of revised algorithms have been proposed to improve TCP performance. In this paper, we propose a new algorithm to improve TCP throughput without modifying the TCP protocol. Since TCP uses acknowledgements (ACKs) to adjust the sending rate, the basic idea of our scheme is to delay (or shape) ACKs traveling through a node where the forward connection is congested. The algorithm aims to fully eliminate packet loss caused by buffer overflow. We implement this scheme in the intermediate nodes connecting satellite links and make a simulation study on its effect. In addition, we test the proposed algorithm in the real world. The results of both simulation and tests show that the proposed scheme improves the TCP throughput by effectively controlling the acknowledgment flow.
The glucocorticoid receptor inhibits NFκB by interfering with serine-2 phosphorylation of the RNA polymerase II carboxy-terminal domain (2000)

Glucocorticoids repress NFkappaB-mediated activation of proinflammatory genes such as interleukin-8 (IL-8) and ICAM-1. Our experiments suggest that the glucocorticoid receptor (GR) confers this effect by associating through protein-protein interactions with NFkappaB bound at each of these genes. That is, we show that the GR zinc binding region (ZBR), which includes the DNA binding and dimerization functions of the receptor, binds directly to the dimerization domain of the RelA subunit of NFkappaB in vitro and that the ZBR is sufficient to associate with RelA bound at NFkappaB response elements in vivo. Moreover, we demonstrate in vivo and in vitro that GR does not disrupt DNA binding by NFkappaB. In transient transfections, we found that the GR ligand binding domain is essential for repression of NFkappaB but not for association with it and that GR can repress an NFkappaB derivative bearing a heterologous activation domain. We used chromatin immunoprecipitation assays in untransfected A549 cells to infer the mechanism by which the tethered GR represses NFkappaB-activated transcription. As expected, we found that the inflammatory signal TNFalpha stimulated preinitiation complex (PIC) assembly at the IL-8 and ICAM-1 promoters and that the largest subunit of RNA polymerase II (pol II) in those complexes became phosphorylated at serines 2 and 5 in its carboxy-terminal domain (CTD) heptapeptide repeats (YSPTSPS); these modifications are required for transcription initiation. Remarkably, GR did not inhibit PIC assembly under repressing conditions, but rather interfered with phosphorylation of serine 2 of the pol II CTD.
Application of the three‐way decomposition for matrix compression (2002)

Abstract We present a new method to compress and invert 3D integral operators on rectangular non‐regular grids. This method requires a small amount of memory to store the compressed matrix and in most cases can provide a good preconditioner for the solution of linear systems with this matrix. We demonstrate efficiency of this method for the solution of some model discrete problems associated with ∫ A ( x̄ , ȳ ) f ( x̄ )d x̄ = u ( ȳ ), x̄ , ȳ ϵℝ 3 , where A ( x̄ , ȳ ) such as 1/∣ x̄ − ȳ ∣ is considered on a non‐regular grid. The arithmetical complexity of matrix–vector and preconditioner–vector multiplications are about N 4/3 operations and there are only about N 2/3 words of memory to store. Copyright © 2002 John Wiley & Sons, Ltd.
The Tail that Wags the Dog: The Globular Tail Domain Defines the Function of Myosin V/XI (2007)

Actin-based organelle movements are driven by the related multifunctional myosin motors of class V in animals and fungi and class XI in plants. The versatility of these motors depends critically on their C-terminal globular tail domain that allows them to bind to a broad variety of cargo molecules. Regulation of this motor-cargo attachment is frequently employed to modulate organelle movement. While the overall structure of the cargo-binding globular tail appears to be conserved between myosin V and XI, it has become apparent that the motor-cargo interactions differ widely even within a single organism and involve protein complexes with different architecture and completely unrelated protein domains. At the same time, indirect evidence suggests that adaptor or receptor dimerization could facilitate efficient myosin capture. Comparison of myosin V and XI across the large evolutionary distance between animals and plants will likely reveal more fundamental insights into these important motors.
Basis and Lattice Polarization Mechanisms for Light Transmission through Nanohole Arrays in a Metal Film (2005)

The extraordinary light transmission through double-hole and elliptical nanohole arrays in a thin gold film is investigated for different orientations of the holes relative to the lattice. Even though these bases have similar symmetry characteristics, the polarization follows the orientation of the basis for the ellipse but remains fixed along a lattice vector for the double holes. Furthermore, the maximum transmitted intensity for linearly polarized light is constant for the ellipse, but decreases for the double holes as they are rotated away from being aligned with the lattice. Finite-difference time-domain simulations agree well with the experimental findings. These experiments show how the basis determines both the coupling into the surface plasmon waves and the evanescent transmission through the nanoholes. Both of these effects need to be considered when designing nanophotonic devices using the extraordinary transmission phenomenon.
Some Ethers of Pentaerythritol and Their Nitrate Esters<sup>1</sup> (1953)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSome Ethers of Pentaerythritol and Their Nitrate Esters1Robert Evans and J. A. GallaghanCite this: J. Am. Chem. Soc. 1953, 75, 5, 1248–1249Publication Date (Print):March 1, 1953Publication History Published online1 May 2002Published inissue 1 March 1953https://pubs.acs.org/doi/10.1021/ja01101a510https://doi.org/10.1021/ja01101a510research-articleACS PublicationsRequest reuse permissionsArticle Views148Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
rTNFα Facilitates Human Polymorphonuclear Leukocyte Adherence to Fibrinogen Matrices With Mobilization of Specific and Tertiary but Not Azurophilic Granule Markers (1991)

rTNF alpha facilitates highly reproducible adherence of polymorphonuclear leukocyte (PMN) to fibrinogen-coated surfaces in a concentration- and time-dependent manner. The adhesion was maximal with 1.0 nM rTNF alpha within 40-50 min at 37 degrees C. A monoclonal antibody (1B4) directed toward the beta 2-chain of the integrin receptor for fibrinogen (CD11b, CD18) completely inhibited the rTNF alpha induced adhesion. TNF alpha caused a time-dependent secretion of the granule markers gelatinase and lactoferrin but no liberation of myeloperoxidase and minimal production of A alpha(1-21), a specific cleavage product of fibrinogen generated by elastase, as markers for the azurophilic granule. PMN adhered to fibrinogen in the presence of rTNF alpha could be further stimulated with cytochalasin B and N-formyl-methionyl-leucyl-phenylalanine (FMLP) to release azurophilic granule markers as measured by increasing MPO activity and A alpha(1-21) production over time. Thus the rTNF alpha-facilitated adherence of PMN to a fibrinogen matrix provides a system for partial activation of PMN resulting in release of markers of specific and tertiary but not azurophilic granules. Moreover, these conditions should provide an opportunity to define more clearly the signal transduction processes involved in azurophilic granule release.
Scattering from inhomogeneous media (1999)

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Chemistry of Phosphorus Ylides Part 42: Reaction of Dipyridyl Ethanedione with Phosphorus Reagents. Cytotoxic Activity of Phosphanylidene-Cyclobutane, Oxaphosphetane, and Pyridazinone (2015)

GRAPHICAL ABSTRACT
Association of IL-1 RN*2 allele and methionine synthase 2756 AA genotype with dementia severity of sporadic Alzheimer's disease (2004)

Distinct determinants of the IL-1 gene cluster are related to the generation and progression of Alzheimer's disease. MTR only influences progression of the disease, which may be enhanced by carriage of allele epsilon4 of APO-E.
Electrochemical Behavior of LiM[sub 0.25]Ni[sub 0.25]Mn[sub 1.5]O[sub 4] as 5 V Cathode Materials for Lithium Rechargeable Batteries (2009)

Glycine-assisted sol-gel–synthesized multiple-doped spinels, (, Fe, and Co) have been studied as cathode materials. The sol-gel technique provides homogeneity, high purity, lower processing temperature, controlled particle size, and morphology. The synthesized samples were subjected to physical characterization studies, viz., thermogravimetric and differential thermal analysis, X-ray diffraction, scanning electron microscopy, X-ray photoelectron spectroscopy, and electrochemical charge–discharge studies. Galvanostatic charge–discharge studies of the samples reveal that using glycine as a chelating agent delivers a stable capacity of even after when cycled between 3 and .
A modified conductance medium for the detection of <i>Salmonella</i> spp. (1987)

Selenite-cystine/trimethylamine oxide/dulcitol medium has been used in conjunction with conductance instruments to detect the presence of Salmonella spp. in foods and faeces. However, a small but significant number of salmonella strains were missed by this method. The majority of these strains were detected when dulcitol was substituted by mannitol and tested on two separate Malthus conductance instruments. Some strains of Citrobacter freundii and Escherichia coli continued to give false positive results. Attempts are made to explain why the substitution of mannitol for dulcitol gives an improved medium.
RF-wafer scale integration: a new approach to active phased arrays (2002)

Active phased array antennas utilize individually packaged transmit/receive modules, which provide both transmitter and receiver functions on /spl lambda/2 wavelength centers. Such modules usually contain 5 to 7 individual GaAs circuits which provide the following functions: transmit amplifier, phase shifter, variable attenuator, T/R switch, and low noise amplifier. The authors describe ongoing efforts in which many T/R modules are fabricated simultaneously on a single 3-inch GaAs-wafer. Redundancy in circuit elements is utilized to obtain high yield. The resulting wafer of GaAs T/R cells is utilized as a layer within a more complex package that includes the individual radiating element. Efforts to date have focused on technology for 2-20 GHz and upon extending the technology to higher frequencies.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>