gebhart/patrepeval huggingface dataset:
Effects of O-Linked Glycosylation on the Cell Surface Expression and Stability of Decay-accelerating Factor, a Glycophospholipid-anchored Membrane Protein (1989)

Decay accelerating factor (DAF) is a glycophospholipid-anchored membrane glycoprotein that protects mammalian host cells from inadvertant complement lysis. The effects of inhibiting mucin-type O-glycosylation on the cell surface expression of DAF were studied by introducing an expression vector for human DAF into wild-type Chinese hamster ovary and ldlD cells. The ldlD cells express reversible defects in the addition of galactose and N-acetylgalactosamine (GalNAc) to oligosaccharide chains on glycoproteins and glycolipids. Mucin-type O-glycosylation of proteins is inhibited in ldlD cells and can be selectively corrected by the addition of GalNAc to the culture medium. The attachment of a phosphatidylinositol phospholipase C-sensitive glycolipid anchor to DAF and its efficient sorting to the cell surface in ldlD cells were independent of galactose and GalNAc additions to glycolipids and proteins. Attachment of galactose and GalNAc to DAF's glycolipid anchor were apparently not required for its normal function. However, in the absence of O-glycosylation DAF was proteolytically cleaved soon after reaching the cell surface, and a large fragment of DAF was released into the culture medium. This rapid proteolysis/release resulted in the expression of very low steady state levels of O-glycosylation-deficient DAF as measured by immunoblotting. These results, in conjunction with those obtained from studies of three other membrane glycoproteins expressed in ldlD cells, suggest that O-linked sugars on membrane glycoproteins may frequently play a role in determining the level of cell surface expression of these proteins.
Marrow transplantation from HLA-identical siblings for treatment of aplastic anemia: is exposure to marrow donor blood products 24 hours before high-dose cyclophosphamide needed for successful engraftment? (1983)

The present study in patients with aplastic anemia was undertaken to determine whether exposure of recipients to donor blood products 24 hr before preparation with cyclophosphamide (1) enhanced the rate of sustained engraftment of marrow from HLA-identical siblings as suggested by animal experiments, (2) increased the rejection rate, in particular in transfused patients who may already have been exposed to donor antigens by blood products, or (3) was of no relevance to the outcome of transplantation of marrow from HLA-identical siblings. One- hundred fifty-five patients were studied, of whom 78 received blood products from the marrow donor 24 hr before cyclophosphamide and 77 did not. A binary logistic regression analysis was applied to the data, simultaneously considering five previously known risk factors for rejection. Results showed that preceding transfusion of donor blood products had neither a significant beneficial nor detrimental effect on the incidence of sustained engraftment.
Low-Rank Kernel Learning with Bregman Matrix Divergences (2009)

In this paper, we study low-rank matrix nearness problems, with a focus on learning low-rank positive semidefinite (kernel) matrices for machine learning applications. We propose efficient algorithms that scale linearly in the number of data points and quadratically in the rank of the input matrix. Existing algorithms for learning kernel matrices often scale poorly, with running times that are cubic in the number of data points. We employ Bregman matrix divergences as the measures of nearness---these divergences are natural for learning low-rank kernels since they preserve rank as well as positive semidefiniteness. Special cases of our framework yield faster algorithms for various existing learning problems, and experimental results demonstrate that our algorithms can effectively learn both low-rank and full-rank kernel matrices.
Immobilization of plasminogen on Escherichia coli flagella (1993)

The interaction of plasminogen with flagella of Escherichia coli was investigated. Plasminogen bound to flagella purified from E. coli LE392, a commonly used cloning host, and E. coli IH3069, and O25H1 strain isolated from a case of newborn bacteremia. The binding was inhibited by the lysine analog є-aminocaproic acid, suggesting involvement of the lysine-binding Kringle domains of plasminogen in the binding. Purified flagella enhanced the formation of plasmin activity in the presence of tissue-type plasminogen activator; a similar enhancement was observed with flagella-expressing LE392 cells.
Trichomoniasis and HIV interactions: a review (2013)

There is strong evidence that TV increases both transmission and acquisition of HIV among women, and that successful treatment for TV can reduce HIV genital shedding. Single dose metronidazole (MTZ) should no longer be used for HIV+ women with TV given the high rates of asymptomatic bacterial vaginosis co-infections and other factors that may render MTZ less effective in HIV+ women. Prevention of TV among HIV+ persons is similar to among HIV, including promotion of condoms as well as regular screening and prompt treatment. There may be a role for expedited partner treatment for the prevention of repeat infections, but most repeat infections are clinical treatment failures. Diligence in screening and treating TV among both HIV- susceptible and HIV+ persons is an important public health strategy.
Joint Multiple Image Parametric Transformation Estimation Via Convolutional Neural Networks (2018)

The correspondence problem is conventionally performed at the pairwise level, i.e., finding the correspondence model, e.g., affine transformation between two input images. While, this paper tackles the scenario when more than two images, e.g., a sequence of images are considered either for model learning or inference. Our proposed approach is based on the recent work on convolutional neural network for geometric matching model. Specifically, we extend this baseline by introducing sequential cycle consistency check that can involve multiple images. The learning is performed in a supervised setting provided with ground truth parametric transformation information, while it meanwhile leverages the consistency information as a regularizer during learning. Extensive experiments are performed on the public benchmark dataset, whereby qualitative and quantitative results are both presented. Our method improves the two-image geometric matching network learning baseline by fusing more than two images' information during learning, while it can still be applied for two-image matching for testing.
Electronic Structure of Impurities in Ferromagnetic Iron. II. 3<i>d</i>and 4<i>d</i>Impurities (1985)

The local magnetic moment M loc , the hyperfine field H hf and the nuclear spin-lattice relaxation time T 1 of 3 d and 4 d transition metal impurities in Fe are calculated in the framework of the Green function method and in the local spin density approximation (LSD). The calculation reproduces the observed major trends of M loc , H hf and T 1 quite well, though the calculated H hf shows a systematic deviation from the experimental values in the case of impurities whose magnetic moment couples parallel to the bulk magnetization. The mechanisms of the variation of these quantities are elucidated in the light of the present ab initio calculation.
Nanophase segregation in binary mixtures of a bent-core and a rodlike liquid-crystal molecule (2010)

We studied mixtures of the achiral bent-core mesogen NOBOW 1,3-phenylene bis[4-(4-9-alkoxyphenyliminonetyl)benzoates] (P-9-O-PIMB) and the small, rodlike liquid crystal 8CB using high-resolution synchrotron x-ray diffraction, freeze fracture transmission electron microscopy, and differential scanning calorimetry. NOBOW and 8CB mix in an isotropic state at high temperatures but phase separate at lower temperatures when NOBOW transforms into the B4 phase and forms chiral helical nanofilaments. In pure NOBOW, the nanofilaments are close packed but at moderate 8CB concentrations, they are separated by nanosized gaps filled by 8CB. At higher concentrations of 8CB, macroscopic phase separation occurs.
Vulcanized meadowfoam oil (1990)

The factice gelation time for meadowfoam oil, along with hardness, color, acetone extract and free sulfur content of the gelled products were compared with gelation time and product properties of factice prepared from seed oils of rapeseed, crambe, soybean, castor, Lesquerella and jojoba. The effect of additives, specifically zinc oxide, magnesium oxide, triethylamine, dicyclohexylamine, 2‐mercaptobenzothiazole and iodine, was also investigated. Both white and brown factices could be prepared from meadowfoam oil and their properties were equivalent to or better than those from high erucic acid rapeseed oil used commercially for the highest quality factice.
Ridge-furrow Detection in Glycine Max Farm Using Deep Learning (2020)

We propose ridge-furrow detection for row-crop farms using DeepLab, which can be trained by RGB color information. Detected images are post-processed as intermediate information that facilitates furrow detection and ridge localization. Using the proposed model, the resultant prediction accuracy is about 84.65%. We deploy the transferred, learned model in a mobile base that navigates along detected furrows of a glycine max farm video. We use row-crop detection information to estimate navigation trajectories and generate line velocity and angular velocity parameters for the mobile base. During navigation of the mobile base, the derived information can be fused for use in extended agricultural tasks such as weeding and other farm labor.
Characterization and compensation of OLED aging in a digital AMOLED system (2015)

Abstract Organic light‐emitting diode (OLED) aging is the root cause for image sticking artifact and considered as the toughest problem besides the low yield problem of active‐matrix organic light‐emitting diode (AMOLED) displays. Digital driving can eliminate Mura artifact and allow a similar yield like LCD. However, it is more prone to OLED aging than analog driving, so that the lifetime will become shorter. In this paper, we pursue the approach to measure the pixel current and compensate OLED I–V drift. Information gained from electrical measurements during the lifetime of the display may be correlated to electro‐optical drift, particularly the current efficiency. The aging model has to consider the dependence of I–V drift and efficiency loss on the operation point/voltage for each subframe. Specific compensation algorithms have been developed. Two AMOLED prototypes (1.5 and 2.8 in.) were validated. Burned‐in pattern can be compensated, so the concept has been proven as effective. With the method described in this paper, digital AMOLED may reach a similar and even significantly higher lifetime than an analog AMOLED.
Interleaving Behavioral and Cycle-Accurate Descriptions for Reconfigurable Hardware Compilation (2005)

This paper describes Haydn, a hardware compilation approach which aims to combine the benefits of cycle accurate descriptions such as ease of control and performance, and the rapid development and design exploration facilities in behavioral synthesis tools. Our approach supports two main features: deriving architectures that meet performance goals involving metrics such as resource usage and execution time, and inferring design behavior by generating behavioral code that is easy to verify and modify from scheduled designs such as pipeline architectures. We report four recent developments that significantly enhance the Haydn approach: (a) a design methodology that supports both cycle-accurate and behavioral levels, in which developers can move from one level to the other: (b) an extended scheduling algorithm which supports operation chaining, pipelined resources (with different latencies and initiation intervals), forwarding technique for loop-carried dependencies, and resource sharing and control; (c) a hardware design flow that can be customized with a script language and extended simulation capabilities for the RC2000 board; and (d) an evaluation of our approach using various case studies, including 3D free-form deformation (FFD), Gouraud shading, Fibonacci series, Montgomery multiplication, and one-dimensional DCT. For instance, our approach has been used to produce various FFD designs in hardware automatically; the smallest at 137 MHz is 294 times faster than software on a dual AMD MP2600+ processor machine at 2.1 GHz, and is 2.7 times smaller and 10% slower than the fastest design at 153 MHz.
Independent and complementary methods for large-scale structural analysis of mammalian chromatin (2007)

The fundamental building block of chromatin, the nucleosome, occupies 150 bp of DNA in a spaced arrangement that is a primary determinant in regulation of the genome. The nucleosomal organization of some regions of the human genome has been described, but mapping of these regions has been limited to a few kilobases. We have explored two independent and complementary methods for the high-throughput analysis of mammalian chromatin structure. Through adaptations to a protocol used to map yeast chromatin structure, we determined sites of nucleosomal protection over large regions of the mammalian genome using a tiling microarray. By modifying classical primer extension methods, we localized specific internucleosomally cleaved mammalian genomic sequences using a capillary electrophoresis sequencer in a manner that allows high-throughput nucleotide-resolution characterization of nucleosome protection patterns. We developed algorithms for the automated and unbiased analysis of the resulting data, a necessary step toward large-scale analysis. We validated these assays using the known positions of nucleosomes on the mouse mammary tumor virus LTR, and additionally, we characterized the previously unreported chromatin structure of the LCMT2 gene. These results demonstrate the effectiveness of the combined methods for reliable analysis of mammalian chromatin structure in a high-throughput manner.
World Cup 2010, what's more important - the ball or the grass? : landscape and turf (2009)

Now with less than 365 days to the kick off of the 2010 World Cup event we still have a long way to go to this eventful day next year. With only a few of the major stadiums complete and other projects still far off the mark we (South Africans) only want to prove that we are capable of delivering - not only on the capability of completing the stadia on time but to deliver a truly world class event that is up to the standards of our predecessors and equal to events of the past.
Delivery of MHEG-5 in a DAVIC ADSL network (1997)

We analyze the delivery of an object-oriented multimedia content model, namely MHFG-5 (Multimedia Hypermedia Expert Group), for interactive multimedia applications in a DAVIC-compliant ADSL access network using low-cost memory-constrained set top units. We present detailed latency budgets for MPEG-2 DSM-CC-based transactions including STU configuration, engine download, and application and scene activation. We use simulation and analysis to assess the tradeoffs in memory management and application response time.
Generation and Use of Orthogonal Polynomials for Data-Fitting with a Digital Computer (1957)

the yk(X,) f,. cannot ordinarily all be made 0 simultaneously. When they cannot, the m conditions (2) compete with one another, and the numerical analyst must somehow take account of this in order to formulate a problem of data-fitting. The m numbers e, = Yk(X,) are the m components of an error vector e. Since the x,, and f,, are regarded as fixed, the vector e depends only on the parameters t(7k), , tk. Each common method for dealing with the competing requirements (2) corresponds to the selection of a norm 11 e 11 for the vector e. The two norms most frequently considered are the minimax norm
ANTAGONISTIC INTERACTIONS OF TRANSFORMING GROWTH FACTORS IN THE REGULATION OF GRANULOSA CELL DIFFERENTIATION (1986)

The role of transforming growth factors (TGFs) in the acquisition of granulosa cell aromatase activity was investigated in vitro in a primary culture of granulosa cells harvested from immature, diethylstilbestrol-treated rats. Basal aromatase activity, as assessed by the generation of radioimmunoassayable estrogen, was negligible, remaining unaffected by treatment with either TGF alpha or TGF beta applied by themselves at the 10 ng/ml dose level. Whereas treatment with FSH produced a substantial increase in the extent of aromatization, concurrent treatment with TGF beta (0.01-10 ng/ml) resulted in dose-dependent augmentation of the FSH effect with an apparent median effective dose of 224 +/- (SE) 32 pg/ml (ca. 9 pM), and a maximal effect 3.6-fold greater than that induced by FSH alone. In contrast, concomitant treatment with TGF alpha (0.01-10 ng/ml) resulted in dose-dependent attenuation of FSH action with an apparent median inhibitory dose of 330 +/- (SE) 40 pg/ml (ca. 60 pM), and a maximal inhibitory effect of 91 +/- (SE) 2%. However, combined treatment with identical (10 ng/ml) maximally effective doses of both TGFs had little or no effect on the FSH-stimulated accumulation of estrogen, suggesting mutual neutralization by the opposing actions of these peptides. Further evaluation of the antagonistic interaction of the TGFs revealed it to be dose-dependent in that maximally effective doses of TGF alpha (10 ng/ml) partially overcame the stimulation of aromatase activity brought about by relatively low (less than 0.3 ng/ml) but not higher (greater than 1 ng/ml) concentrations of TGF beta, thereby shifting the TGF beta dose-response curve to the right. Treatment with either TGF had no significant effect on granulosa cell DNA content or synthesis, plating efficiency or viability. Taken together, these findings suggest that picomolar concentrations of exogenously provided TGF alpha TGF beta exert potent but diametrically opposed effects on the acquisition of granulosa cell aromatase activity and that the interaction between these two peptides is antagonistic in nature. Our findings further suggest that these direct cytodifferentiative effects of the TGFs may represent intrinsic novel properties of these peptides distinct from their well-established role in the regulation of cellular growth.
Phosphatidylcholine as a precursor of choline for acetylcholine synthesis. (1987)

It has been hypothesized that the selective vulnerability of certain brain cholinergic neurons in Alzheimer's disease may reflect the unique way that choline is utilized by these neurons, i.e. not only as a component of major membrane phospholipids, e.g. phosphatidylcholine (PC), but also as a precursor of their neurotransmitter, acetylcholine (ACh). A prolonged utilization of choline liberated from PC, for ACh production, without adequate resynthesis of this lipid, might result in a net loss of the phosphatide followed by an impairment of membrane function and loss of cellular viability. Studies described in this paper, performed on electrically stimulated striatal slices and on cholinergic cell lines, test this hypothesis. 1) Electrically-stimulated striatal slices continue to release ACh, and sustain their free choline and ACh levels, even when perfused with a choline-free medium. Striatal levels of PC decline under these circumstances, and this decline can be blocked by adding tetrodotoxin (which blocks neuronal depolarization) or choline to the medium. The other major membrane phospholipids, phosphatidylserine and phosphatidylethanolamine, also decline proportionately to PC when slices are stimulated in the absence of choline. 2) In a population of purely cholinergic cells (human neuroblastoma, LA-N-2), ACh can be synthesized from choline derived from degradation of endogenous PC formed de novo by methylation of phosphatidylethanolamine. 3) PC content of cells in culture (neuroblastoma X glioma hybrid, NG 108-15) can be altered by adding various amounts of choline to the growth media. The proportion of PC in the cells apparently affects cellular survival and rate of growth. Taken together these data demonstrate that cholinergic neurons utilize the choline stored in PC to synthesize ACh; that this process may lead to a depletion in membrane phospholipids (when choline supply is inadequate); and that the resulting changes in neuronal membrane composition might adversely affect cellular viability.
Effects of Polymerization Temperature on Structure (1949)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffects of Polymerization Temperature on StructureA. W. MeyerCite this: Ind. Eng. Chem. 1949, 41, 8, 1570–1577Publication Date (Print):August 1, 1949Publication History Published online1 May 2002Published inissue 1 August 1949https://pubs.acs.org/doi/10.1021/ie50476a016https://doi.org/10.1021/ie50476a016research-articleACS PublicationsRequest reuse permissionsArticle Views129Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Magnetoresistance of Mn:Ge ferromagnetic nanoclusters in a diluted magnetic semiconductor matrix (2001)

We have fabricated a thin film magnetic system consisting of nanoscale Mn11Ge8 ferromagnetic clusters embedded in a MnxGe1−x dilute ferromagnetic semiconductor matrix. The clusters form for growth temperatures of ∼300 °C with an average diameter and spacing of 100 and 150 nm, respectively. While the clusters dominate the magnetic properties, the matrix plays a subtle but interesting role in determining the transport properties. Variable range hopping at low temperatures involves both nanoclusters and MnGe sites, and is accompanied by a negative magnetoresistance attributed in part to spin-dependent scattering analogous to metallic granular systems.
High Power Density and High Temperature Converter Design for Transportation Applications (2012)

The continual development of high-power-density power electronic converters is driven particularly by modern transportation applications like electrical vehicles and more electric aircraft where the space and carrier capability is limited. However, there are several challenges related to transportation applications such as fault tolerance for safety concern, high temperature operation in extreme environments and more strict electromagnetic compatibility requirement. These challenges will increase difficulties for more electrical system adoption in the transportation applications. In this dissertation, comprehensive methodologies including more efficient energy storage solution, better power electronics devices capability, better packaging performance and more compact EMI filter design are analyzed and proposed for the goal of high power density converter design in transportation applications.
The Intelligent Asset Allocator: How to Build Your Portfolio to Maximize Returns and Minimize Risk (2000)

General Considerations. Risk and Return. The Behavior of Multiple-Asset Portfolios. The Behavior of Real-World Portfolios. Optimal Asset Allocations. Market Efficiency. Odds and Ends. Implementing Your Asset Allocation Strategy. Investment Resources. Appendices.