gebhart/patrepeval huggingface dataset:
IL-7-Dependent Extrathymic Expansion of CD45RA+ T Cells Enables Preservation of a Naive Repertoire (1998)

We have investigated the regulation of adult and cord blood CD45RA+ T cell proliferation and apoptosis to identify factors that may control the naive T cell pool. Cord CD45RA+ T cells were highly susceptible to spontaneous apoptosis as compared with CD45RA+ T cells from adults. Apoptosis was prevented by the addition of IL-2, IL-4, IL-7, and IL-15 which signal via the gamma-chain of the IL-2 receptor. IL-7 prevented the decrease in Bcl-2 and Bcl-xL and induced cell cycling in up to 20% of cord T cells after 8 days, resulting in a threefold increase in cord T cell numbers. However, the expanded cells retained a CD45RA+ CD45RO- phenotype. Similar results were obtained with adult CD45RA+ T cells. IL-7-expanded CD45RA+ RO- T cells expressed CD45RO after stimulation through the TCR. Investigations into the regulation of replicative senescence showed that after 12 days in culture with IL-7, cord blood CD45RA+ T cell proliferation resulted in telomere shortening. Nevertheless, IL-7-expanded cord blood T cells still maintained longer telomeres than unstimulated adult T cells. IL-7 but not IL-2 could directly induce high telomerase activity which probably retarded the rate of telomere shortening in cord blood T cells. These results suggest that proliferation induced by IL-7 may be important for extrathymic expansion of neonatal CD45RA+ T cells and may also contribute to the maintenance of the adult CD45RA+ T cell pool.
Noninvasive<i>in vivo</i>detection and quantification of<i>Demodex</i>mites by confocal laser scanning microscopy (2012)

With the help of CLSM it is possible to detect, image and quantify Demodex mites noninvasively in facial skin of patients with rosacea.
Accuracy of Physical Examination and Intra‐Access Pressure in the Detection of Stenosis in Hemodialysis Arteriovenous Fistula (2008)

Both physical examination (PE) and intra-access pressure (IAP) measurements have been used in the identification of stenosis in an arteriovenous access. The aim of this study was to evaluate the accuracy of PE and IAP in the diagnosis of arteriovenous fistula (AVF) stenosis. A total of 84 patients were enrolled in the study (54% men, mean age of 50.7 +/- 12.7 years and mean AVF patency of 24.9 +/- 7.8 months, 52% radiocephalic). Abnormalities of pulse and thrill were used as the diagnostic tools for the detection of stenosis using the physical examination. For IAP, stenosis was suspected when the ratio between IAP at the arterial puncture site and the mean blood pressure was <0.13 or >0.43. The diagnosis of stenosis was confirmed by Doppler ultrasound (DU). Sensitivity (S), specificity (SP), positive predictive value (PPV), negative predictive value (PNV), and accuracy were calculated for the two early detection tests. According to DU, 50 (59%) AVF were considered positive for the presence of stenosis. Fifty-six (66%) AVF were considered positive for the presence of stenosis by PE and 34 (40%) by IAP. S, SP, PPV, and NPV for PE and IAP were 96%, 76%, 86%, and 93% and 60%, 88%, 88%, and 60%, respectively. The accuracy for PE and IAP was 88% and 71%, respectively. PE proved to be an accurate method for the diagnosis of stenosis and should be part of all surveillance protocols of stenosis detection in AVF.
Simple model for an optimiser (1988)

A simple model of a building is developed to analyse the preheating curve for optimised heating. The model considers an effective thermal mass of the building so that internal air temperature can be used rather than a mean fabric temperature. With this model a curve similar to that of Birtles and John is derived. At low outside temperatures and with small heating plant this curve is found to bend over. The model results can be explained in terms of a time constant and a plant size ratio. Variable heat emitter output is also considered and the characteristic curve retains the same form. Birtles and John's empirical constants are related to building parameters of the simple model. The response factor for a building as used in the CIBSE Energy Code is found to relate approximately to the model. It is pointed out, however, that the CIBSE admittance method used in deriving the response factor is slightly erroneous. A number of other points relating to optimiser performance are explained by the model.
Effects of R-Alpha Lipoic Acid on HbA1c, Lipids and Blood Pressure in Type-2 Diabetics: A Preliminary Study (2009)

R-alpha lipoic acid (R-ALA) supplementation improves blood glucose in diabetic animals, but there have been no long-term clinical trials in humans testing its use for glucose control (HbA1c). This double-blind study pre-/post-test control group (PL) design sought to determine the effect of R-ALA on HbA1c. Twenty type-2 diabetics were randomly assigned to 200 mg capsules of R-ALA (n=13; 8M 5F) or PL (n=7; 2M 5F) 3 times daily, 30 minutes before meals (600 mg total) for 91 days. Samples were obtained for HbA1c at baseline and day 91. No significant differences between R-ALA and PL groups were found at baseline or day 91. However, three distinct reactions to the supplement were noted. The first group (n=3) responded to R-ALA with a >25% drop in HbA1c range from 6.1-12.5 to 6.2- 9.0 mg/dL and/or halved their anti-diabetic medication. The second group (n=5) had no change in HbA1c. The third group (n=5) had changes in medication or concurrent chronic adverse events that should have raised HbA1c, but did not beyond that of the placebo. Conclusions: Three months of R-ALA supplementation may lower HbA1c in a small number of individuals. However, to further confirm these findings, larger studies of longer duration are needed.
Non-Monotonic Sequential Text Generation (2019)

Standard sequential generation methods assume a pre-specified generation order, such as text generation methods which generate words from left to right. In this work, we propose a framework for training models of text generation that operate in non-monotonic orders; the model directly learns good orders, without any additional annotation. Our framework operates by generating a word at an arbitrary position, and then recursively generating words to its left and then words to its right, yielding a binary tree. Learning is framed as imitation learning, including a coaching method which moves from imitating an oracle to reinforcing the policy's own preferences. Experimental results demonstrate that using the proposed method, it is possible to learn policies which generate text without pre-specifying a generation order, while achieving competitive performance with conventional left-to-right generation.
Fault-tolerant communication over Micronmesh NOC with Micron Message-Passing protocol (2009)

In the future multi-processor system-on-chip (MPSoC) platforms are becoming more vulnerable to transient and intermittent faults due to physical level problems of VLSI technologies. This sets new requirements to the fault-tolerance of the messaging layer software which applications use for communication, because the faults make the operation of the Network-on-Chip (NoC) hardware of the MPSoCs less reliable. This paper presents Micron Message-Passing (MMP) Protocol which is a light-weight protocol designed for improving the fault tolerance of the messaging layer of the MPSoCs where Micronmesh NoC is used. Its fault-tolerance is implemented by watchdog timers and cyclic redundancy checks (CRC) which are usable for detecting packet losses, communication deadlocks, and bit errors. These three functionalities are necessary, because without them the software executed on the MPSoCs is not able to detect the faults and recover from them. This paper presents also how the MMP Protocol can be used for implementing applications which are able to recover from communication faults.
H5-Type Influenza Virus Hemagglutinin Is Functionally Recognized by the Natural Killer-Activating Receptor NKp44 (2007)

Antiviral immune defenses involve natural killer (NK) cells. We previously showed that the NK-activating receptor NKp44 is involved in the functional recognition of H1-type influenza virus strains by NK cells. In the present study, we investigated the interaction of NKp44 and the hemagglutinin of a primary influenza virus H5N1 isolate. Here we show that recombinant NKp44 recognizes H5-expressing cells and specifically interacts with soluble H5 hemagglutinin. H5-pseudotyped lentiviral particles bind to NK cells expressing NKp44. Following interaction with target cells expressing H5, pseudotyped lentiviral particles, or membrane-associated H5, NK cells show NKp44-mediated induced activity. These findings indicate that NKp44-H5 interactions induce functional NK activation.
Cytotoxicity and subcellular localization of boronated phenanthridinium analogues. (1997)

Binding and toxicity of boronated phenanthridinium analogues were studied in vitro using cultured human malignant glioma cells. The compounds, 5-ortho- (5-o-CP), 5-para- (5-p-CP), 5-nido- (5-n-CP) and 6-nido-carboranyl phenanthridinium (6-n-CP) showed varying toxic effects. The cells were exposed to the compounds for 2 or 24 h. The span between non-toxic and toxic concentrations seemed to be very narrow. 5-p-CP was the most toxic compound, causing total cell death at a concentration of 5 micrograms/ml cell culture medium. None of the compounds showed toxic effects at a concentration of 1 microgram/ml. Viable cells incubated with the compounds at this concentration showed a > 100-fold accumulation of boron. Only approximately 1/4 of this accumulation was found in cells permeabilized and inactivated with acetone. Fluorescent images of acetone-treated cells showed clear uptake of the compounds in the cell nucleus, as for ethidium bromide, while for viable cells binding to structures other than DNA was also observed. These results were confirmed by subcellular boron determination. All tested compounds intercalate into DNA, as was demonstrated in cell-free systems with calf thymus DNA. The hypothesis is that the compounds are trapped in the cellular membranes of viable cells because of their lipophilicity, before reaching nuclear DNA.
GaAs laser array source package (1977)

A GaAs laser array multispot source has been fabricated in which the array is bonded to a silicon substrate, which also contains an accurately aligned collimating lens and an array of fiber lightguides. The coupling efficiency of each laser to its corresponding lightguide is greater than 50%. The package is cooled by a thermoelectric cooler, allowing cw, room-temperature operation of the array at 5 mW output per fiber. This source is useful for multichannel optical-communication applications.
Determining redundancy levels for fault tolerant real-time systems (1995)

Many real-time systems have both performance requirements and reliability requirements. Performance is usually measured in terms of the value in completing tasks on time. Reliability is evaluated by hardware and software failure models. In many situations, there are trade-offs between task performance and task reliability. Thus, a mathematical assessment of performance-reliability trade-offs is necessary to evaluate the performance of real-time fault-tolerance systems. Assuming that the reliability of task execution is achieved through task replication, we present an approach that mathematically determines the replication factor for tasks. Our approach is novel in that it is a task schedule based analysis rather than a state based analysis as found in other models. Because we use a task schedule based analysis, we can provide a fast method to determine optimal redundancy levels, we are not limited to hardware reliability given by constant failure rate functions as in most other models, and we hypothesize that we can more naturally integrate with online real-time scheduling than when state based techniques are used. In this work, the goal is to maximize the total performance index, which is a performance-related reliability measurement. We present a technique based on a continuous task model and show how it very closely approximates discrete models and tasks with varying characteristics.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Minimally Invasive Surgery (1987)

Urology has been a leader in the trend toward minimizing the invasiveness of surgery, and the author, a urologist, established a Department of Minimally Invasive Surgery in 1986. This article reviews developments to date on minimally invasive procedures in urology, gastroenterology, vascular surgery, orthopedics, thoracic surgery, neurosurgery, otolaryngology, and gynecology and speculates about near-term and long-range future developments. These changes may mandate alterations in surgical training. The surgical profession must prepare itself for an almost total change in professional direction.
The Dissolution and Condensation Reactions of Guaiacyl and Syringyl Units in Residual Lignin during Kraft Delignification of Sweetgum (1990)

Article The Dissolution and Condensation Reactions of Guaiacyl and Syringyl Units in Residual Lignin during Kraft Delignification of Sweetgum was published on January 1, 1990 in the journal Holzforschung (volume 44, issue 2).
Cleaning-in-place in the dairy industry: criteria for reuse of caustic (NaOH) solutions (2002)

Cleaning-in-place NaOH solutions from a milk standardisation dairy plant are reused for several days before being discharged to the purification station. During reuse the surface tension of the industrial cleaning solutions was reduced from ~70 mJ . m -2 for newly prepared NaOH down to ~30 mJ . m -2 during the week. The decrease was rapid during the first few reuse cycles and stabilised thereafter, while the polluting load and suspended solids increased inversely. The cleaning efficiency test consisted of an ultrafiltration membrane fouled with whey proteins, which was cleaned using these cleaning solutions, either without any treatment, or following crossflow micro-and nanofiltration. It was found that microfiltrates and nanofiltrates with both low surface tension and suspended solids resulted in higher efficiency and cleanliness, and a much faster cleaning rate. The effects of suspended solids and low surface tension will have to be further studied to determine the role of each parameter and confirmed on stainless steel surfaces and in a milk processing plant.
Leaky Dispersion Characteristics in Circular Dielectric Rod Using Davidenko (2005)

The leaky dispersion characteristics of a circular dielectric rod were investigated using Davidenko's method for several lower-order transverse magnetic(TM) modes. The normalized complex propagation constants were precisely determined and their tolerances below 10-10 compared with zero for both real and imaginary parts. It was also checked whether the normalized complex propagation constants obtained represented forward leaky waves. The leaky modes existing below the cutoff frequency of the guided mode were classified as a nonphysical mode, reactive mode, antenna mode, and spectral gap based on a precise determination of the complex propagation constants. Finally, the effects of the dielectric constant and radius of the dielectric rod on the leaky dispersion characteristics were also considered.
Las chicas modernas se emplean como dactilógrafas (2012)

During the 1920’s, the “modern girl” arose in Buenos Aires spreading the new beauty standards by establishing the requirements for the new administrative jobs a lot of women began to apply for. The result was the “typist” stereotype shown in comics, journalist’s columns and advertising. The purpose of this article is to analyse such stereotype trying to interpret the social meanings obtained both by the change in fashion and the fact that women started working in those administrative positions that appeared while the dominating gender mandates reinforced the femininity ideas defined by domesticity and motherhood.
Naphthenic Acids in Coastal Sediments after the <i>Hebei Spirit</i> Oil Spill: A Potential Indicator for Oil Contamination (2014)

Naphthenic acids (NAs) as toxic components in most petroleum sources are suspected to be one of the major pollutants in the aquatic environment following oil spills, and the polarity and persistence of NAs make it a potential indicator for oil contamination. However, the contamination and potential effects of pollutants in oil spill affected areas remain unknown. To investigate NAs in oil spill affected areas, a sensitive method was first established for analysis of NAs, together with oxy-NAs in sediment samples by UPLC-QTOF-MS. Then the method was applied to determine the NA mixtures in crude oil, weathered oil, and sediments from the spilled sites after the Hebei Spirit oil spill, Taean, South Korea (Dec. 2007). Concentrations of NAs, O3-NAs, and O4-NAs were found to be 7.8-130, 3.6-44, and 0.8-20 mg kg(-1) dw in sediments from the Taean area, respectively, which were much greater than those measured in the reference sites of Manlipo and Anmyundo beaches. Concentrations of NAs were 50-100 times greater than those (0.077-2.5 mg kg(-1) dw) of PAHs in the same sediment samples, thus the ecological risk of NAs in oil spill affected areas deserves more attention. The sedimentary profiles of oil-derived NAs and background NAs centered around compounds with 21-35 and 12-21 carbons, respectively, indicating that the crude-derived NA mixtures originating from the 2007 oil spill were persistent. Acyclic NAsn=5-20 were easily degraded compared to cyclic NAsn=21-41 during the oil weathering processes, and the ratio of oxy-NAsn=21-41 relative to NAsn=21-41 could be a novel index to estimate the degree of oil weathering in sediments. Altogether, the persistent oil-derived NAsn=21-41 could be used as a potential indicator for oil-specific contamination, as such compounds would not be much affected by the properties of coastal sediments possibly due to the high sorption of the negatively charged compounds (NAs) in sediment.
Comparison of milk production costs among EU members (2009)

This paper attempts to identify factors which influence the effectiveness of milk production. The basic aim is to compare levels of costs in the dairy industry between Czech and European producers. The average cost per 100 kg ECM milk is determined from data provided by the European Dairy Farmers association (EDF). The total costs per 1 litre of Czech milk producers are on the European average level with high production efficiency. The problem is only in the utilisation of basic production factors, especially land and labour.
Platform IC with embedded via programmable logic for fast customization (2004)

Application-specific standard products (ASSPs) have been so far customized by an increasing amount of embedded software or very recently by electrically and mask-programmable embedded gate-arrays. The solution proposed in this paper addresses both the large demand for higher flexibility and the need for fast product turn-around time. This is achieved by using single-via programmable logic and consistent hardware and software co-design flow. The system architecture is discussed as well as the design flows for pre- and post-silicon design and customization. The silicon area required by the system is 23 mm/sup 2/ in a 0.13 /spl mu/m CMOS technology. The embedded via-programmable logic accounts for about 30% of the system area.
Locating the greenhouse (2003)

The Oklahoma Cooperative Extension Service periodically issues revisions to its publications. The most current edition is made available. For access to an earlier edition, if available for this title, please contact the Oklahoma State University Library Archives by email at libscua@okstate.edu or by phone at 405-744-6311.
A Study of Student-Teacher Grading Interaction Process (1976)

The extent and nature of student involvement in the teaching-learning process are a continuing problem. Students want to play a more positive part in shaping their future. This study shows that the computer can help integrate student input into their grade. The authors are faculty members at Illinois State University, Normal. Mildred Pratt: Assistant Professor of Sociology-Anth ropology (M.A., Butler; M.A., Indiana; Ph.D., Pitts burgh). T. A. E. C. Pratt: Assistant Professor of Physics (B.A., Hampton Institute; M.S., Ph.D., Carnegie Mellon).
Chemistry in Environmentally Benign Media. 7.<sup>1</sup> Chelating Hydroxymethyl-Functionalized Bisphosphines as Building Blocks to Water-Soluble and <i>in-Vitro</i>-Stable Gold(I) Complexes. Synthesis, Characterization, and X-ray Crystal Structures of [Au{(HOH<sub>2</sub>C)<sub>2</sub>PC<sub>6</sub>H<sub>4</sub>P(CH<sub>2</sub>OH)<sub>2</sub>}<sub>2</sub>]Cl and [Au<sub>2</sub>{(HOH<sub>2</sub>C)<sub>2</sub>PCH<sub>2</sub>CH<sub>2</sub>P(CH<sub>2</sub>OH)<sub>2</sub>}<sub>2</sub>]Cl<sub>2</sub> (1997)

The reactions of water-soluble bisphosphines (HOH(2)C)(2)PC(6)H(4)P(CH(2)OH)(2) (1) and (HOH(2)C)(2)PCH(2)CH(2)P(CH(2)OH)(2) (2) with NaAuCl(4), in aqueous media, or AuClPPh(3), in biphasic media (aqueous/organic), produced the water/alcoholic-soluble Au(I) complexes [Au{(HOH(2)C)(2)PC(6)H(4)P(CH(2)OH)(2)}(2)]Cl (3), [Au{(HOH(2)C)(2)PCH(2)CH(2)P(CH(2)OH)(2)}(2)]Cl (4), and [Au(2){(HOH(2)C)(2)PCH(2)CH(2)P(CH(2)OH)(2)}(2)]Cl(2) (5) in near quantitative yields. Stability and cysteine-challenge studies of 3 indicate the kinetic inertness of these new complexes. Complex 5 is luminescent in the solid state at room temperature. When excited at 280 nm in non-degassed water at room temperature, the emission spectrum shows a high-energy band at 310 nm and a low-energy band at 560 nm. The large Stokes shift for the low-energy band implies that the emission is phosphorescence. The X-ray structures of 3 and 5, reported in this paper, confirm the gold(I) structures of this new generation of water-soluble transition metal complexes. All compounds were characterized by (31)P and (1)H NMR spectroscopy and mass spectroscopy. X-ray data for 3: monoclinic, P2(1)/m, a = 9.8715(5) Å, b = 9.9465(5) Å, c = 14.5621(8) Å, beta = 106.5930(10) degrees, Z = 2, R = 0.032 (R(w) = 0.050). X-ray data for 5: monoclinic, C2/c, a = 29.7128(14) Å, b = 16.7062(8) Å, c = 22.3762 (11) Å, beta = 117.6970(10) degrees, Z = 16, R = 0.051 (R(w) = 0.072).
Harnessing Listeria monocytogenes to target tumors (2010)

Because of its cytosolic localization, Listeria monocytogenes (LM) has long been considered an attractive tool for delivering tumor-associated antigens (TAA) antigens in vivo to combat cancer. LM directly infects antigen-presenting cells (APC) such as monocytes, macrophages and dendritic cells (DC), thereby delivering the TAA into their cytoplasm, resulting in processing, and presentation of the antigen to the immune system. This activates adaptive and innate immune responses to the TAA, mediating tumor cell cytolysis. Recently we discovered additional pathways by which Listeria can be harnessed to induce tumor cell death, which suggest new directions in the development of vaccines or therapies against cancer. In one approach, we have used Listeria to induce immune responses that destroy tumor vasculature. Another new pathway involves selective infection of cancer cells with Listeria, followed by tumor cell death through the production of high levels of reactive oxygen species (ROS) and through Listeria-specific cytotoxic T lymphocytes (CTL). This review will focus on the most recent studies on the multiple pathways of LM and how they can be harnessed in the battle against cancer.
Coordination Between Nitric Oxide and Superoxide Anion Radical During Progressive Exercise in Elite Soccer Players (2010)

The regression lines of NO(2) (-) and O(2) (-) crossed at the level of anaerobic threshold, suggesting that anaerobic threshold could be of a crucial importance not only in the anaerobic and aerobic metabolism but in mechanisms of signal transductions as well. Long-term exercise increases NO bioavailability, and there is positive correlation between NO bioavailability and maximal oxygen uptake (VO(2max)).