gebhart/patrepeval huggingface dataset:
Clinical, Hematological, and Biochemical Analysis of Experimental Endotoxemia in Thoroughbred Horses (2003)

To evaluate the biological response of the horse to endotoxemia, a sublethal amount of lipopolysaccharide (LPS) (10 μg/kg) was given to two Thoroughbreds in two doses 24 hr apart. Each infusion initially produced a significant increase or decrease in rectal temperature, an increase in respiratory rate and heart rate, and a marked decrease in white blood cell count (WBC). The horses subsequently showed signs of shock, characterized by extreme coldness of the skin of lower limbs, as well as cyanosis of the visible mucosae, oliguria accompanied by proteinuria, and abnormalities in gastrointestinal function. The clinical signs of equine endotoxemia may be manifested by the clinical condition of the systemic inflammatory response syndrome (SIRS): two or more of the above signs, such as high or low rectal temperature, increased heart rate and respiratory rate, and leukopenia. Pathobiological responses such as a severe decrease in the number of platelets, hypoglycemia, metabolic acidosis, disorders of hemostasis accompanied by cyanosis of the visible mucosal membranes, proteinuria and oliguria, and abnormal gastrointestinal function, may be manifestations of pathobiological conditions ranging from disseminated intravascular coagulation (DIC) to multiple organ dysfunction syndrome (MODS). Therefore, the clinicopathological responses in equine endotoxemia suggest the nature of SIRS elicited by hypercytokinemia progressing into septic shock.
Role of the glucosamine pathway in fat-induced insulin resistance. (1997)

To examine whether the hexosamine biosynthetic pathway might play a role in fat-induced insulin resistance, we monitored the effects of prolonged elevations in FFA availability both on skeletal muscle levels of UDP-N-acetyl-hexosamines and on peripheral glucose disposal during 7-h euglycemic-hyperinsulinemic (approximately 500 microU/ml) clamp studies. When the insulin-induced decrease in the plasma FFA levels (to approximately 0.3 mM) was prevented by infusion of a lipid emulsion in 15 conscious rats (plasma FFA approximately 1.4 mM), glucose uptake (5-7 h = 32.5+/-1.7 vs 0-2 h = 45.2+/-2.8 mg/kg per min; P < 0.01) and glycogen synthesis (P < 0.01) were markedly decreased. During lipid infusion, muscle UDP-N-acetyl-glucosamine (UDP-GlcNAc) increased by twofold (to 53.4+/-1.1 at 3 h and to 55.5+/-1.1 nmol/gram at 7 h vs 20.4+/-1.7 at 0 h, P < 0.01) while glucose-6-phosphate (Glc-6-P) levels were increased at 3 h (475+/-49 nmol/gram) and decreased at 7 h (133+/-7 vs 337+/-28 nmol/gram at 0 h, P < 0.01). To discern whether such an increase in the skeletal muscle UDP-GlcNAc concentration could account for the development of insulin resistance, we generated similar increases in muscle UDP-GlcNAc using three alternate experimental approaches. Euglycemic clamps were performed after prolonged hyperglycemia (18 mM, n = 10), or increased availability of either glucosamine (3 micromol/kg per min; n = 10) or uridine (30 micromol/kg per min; n = 4). These conditions all resulted in very similar increases in the skeletal muscle UDP-GlcNAc (to approximately 55 nmol/gram) and markedly impaired glucose uptake and glycogen synthesis. Thus, fat-induced insulin resistance is associated with: (a) decreased skeletal muscle Glc-6-P levels indicating defective transport/phosphorylation of glucose; (b) marked accumulation of the endproducts of the hexosamine biosynthetic pathway preceding the onset of insulin resistance. Most important, the same degree of insulin resistance can be reproduced in the absence of increased FFA availability by a similar increase in skeletal muscle UDP-N-acetyl-hexosamines. In conclusion, our results support the hypothesis that increased FFA availability induces skeletal muscle insulin resistance by increasing the flux of fructose-6-phosphate into the hexosamine pathway.
Multifunctional drugs with different CNS targets for neuropsychiatric disorders (2006)

The multiple disease etiologies that lead to neuropsychiatric disorders, such as Parkinson's and Alzheimer's disease, amyotrophic lateral sclerosis, Huntington disease, schizophrenia, depressive illness and stroke, offer significant challenges to drug discovery efforts aimed at preventing or even reversing the progression of these disorders. Transcriptomic tools and proteomic profiling have clearly indicated that such diseases are multifactorial in origin. Further, they are thought to be initiated by a cascade of molecular events that involve several neurotransmitter systems. In response to this complexity, a new paradigm has recently emerged that challenges the widely held assumption that 'silver bullet' agents are superior to 'dirty drugs' in therapeutic approaches aimed at the prevention or treatment of neuropsychiatric diseases. A similar pattern of drug development has occurred in strategies for the treatment of cancer, AIDS and cardiovascular diseases. In this review, we offer an overview of therapeutic strategies and novel investigative drugs discovered or developed in our own and other laboratories, that address multiple CNS etiological targets associated with an array of neuropsychiatric disorders.
Tumor necrosis factor increases the number of epidermal growth factor receptors on human fibroblasts. (1987)

Tumor necrosis factor (TNF) was shown previously to stimulate the growth of human FS-4 fibroblasts. Here we show that human recombinant TNF can increase the binding of epidermal growth factor (EGF) to these cells. Incubation with TNF resulted in a 40-80% increase in the number of EGF-binding sites with no apparent change in receptor binding affinity. The increase in EGF binding was apparent 8-12 h after the addition of TNF. TNF also increased the amount of EGF receptor protein immunoprecipitated from cells labeled with [35S]methionine. Stimulation of EGF receptor protein synthesis was demonstrable 2-4 h following TNF treatment. TNF increased EGF binding with a dose-response relationship similar to that reported earlier for the mitogenic action. Increased expression of EGF receptors, due to enhanced synthesis of the EGF receptor protein, may be functionally related to the mitogenic action of TNF in human fibroblasts.
Magnetic properties of amorphous FeP alloys containing Ga, Ge, and As (1974)

The magnetic properties of rapidly quenched Fe83−xP17Ex (E = Ga, Ge, As) alloys over the composition range of x = 2 to 8 at% were studied. The specimens were prepared by the Taylor-technique. For supersaturated solid solutions as well as amorphous samples coercitive force values Hc are found of the same order of magnitude. The results indicate that low values of Hc for rapidly quenched alloys are not representative for structural disorder. Die magnetischen Eigenschaften von schnell abgeschreckten Fe83−xP17Ex Legierungen (E = Ga, Ge, As) wurden im Bereich von x = 2 bis 8 at% untersucht. Die Proben wurden mit dem Taylor-Verfahren hergestellt. Die Messungen der Koerzitivfeldstärke Hc ergeben für übersättigte Mischkristalle und amorphe Phasen dieselbe Größenordnung. Die Resultate zeigen, daß niedrige Hc-Werte für schnell abgeschreckte Legierungen nicht repräsentativ für ungeordnete Strukturen sind.
Poling of Lead Zirconate Titanate Ceramics and Flexible Piezoelectric Composites by the Corona Discharge Technique (1989)

In the conventional poling method, piezoelectric ceramics and composites are poled by applying a large dc voltage. Poling of composites having a polymer matrix with 0–3 connectivity is especially difficult because the electric field within the high‐dielectricconstant grains is far smaller than in the low‐dielectric‐constant polymer matrix. Therefore, very large electric fields are required to pole these types of composites. However, large electric fields often cause dielectric breakdown of the samples. In this study for improved poling, the corona discharge technique was used to pole piezoelectric ceramics, fired PZT composites, and 0.5PbTiO 3 · 0.5BiFeO 3 0–3 polymer composites. An experimental setup for corona poling is described. The dielectric and piezoelectric properties of materials poled by the corona discharge technique were comparable to those obtained with the conventional poling method.
Thermal behaviour of partially neutralised ethylene‐maleic acid copolymer (1989)

Abstract As part of continuing studies on the cure of candidate polymers for waterborne coatings, the thermal behaviour of partially neutralised ethylene‐maleic acid copolymer, EMA, has been examined. Films of EMA neutralised with a variety of bases were heated at 250°C. For this copolymer, as for poly(acrylic acid) at the same temperature, reflectance infrared spectroscopy has shown that heating led initially to anhydride formation. In the unneutralised state, or with the divalent ions calcium, magnesium, cobalt or zinc, further heating led to little or no further reaction. By contrast, the presence of univalent metal ions lithium, sodium and potassium caused a second reaction to occur, namely decarboxylation to yield keto crosslinks. This second reaction, however, did not occur to the extent that it does with poly(acrylic acid) under identical conditions. Possible reasons for this are discussed. Unlike poly(acrylic acid), EMA when partially neutralised was found not to form continuous films on the tin‐plate substrate.
Emulating rough and growl voice in spectral domain (1998)

This paper presents a new approach on transforming a modal voice into a rough or growl voice. The goal of such transformations is to be able to enhance voice expressiveness in singing voice productions. Both techniques work with spectral models and are based on adding sub-harmonics in frequency domain to the original input voice spectrum. 1.
A diagnostic and family study of posttraumatic stress disorder (1985)

A family history study of 36 patients with chronic posttraumatic stress disorder revealed a positive history of familial psychopathology in 66% of the patients. Alcoholism, depression, and anxiety disorders were the disorders most commonly found. The patients also had a higher prevalence of alcoholic siblings than did a retrospectively derived control group of depressed and anxious male patients. With respect to the proportion of familial anxiety to familial depression, the probands with posttraumatic stress disorder more closely resembled probands with generalized anxiety than probands with depression. Every patient had experienced at least one significant psychiatric illness during his lifetime, most commonly alcohol abuse or depression.
Service Quality of Online Shopping Platforms: A Case-Based Empirical and Analytical Study (2013)

Customer service is crucially important for online shopping platforms (OSPs) such as eBay and Taobao. Based on the well-established service quality instruments and the scenario of the specific case on Taobao, this paper focuses on exploring the service quality of an OSP with an aim of revealing customer perceptions of the service quality associated with the provided functions and investigating their impacts on customer loyalty. By an empirical study, this paper finds that the “fulfillment and responsiveness” function is significantly related to the customer loyalty. Further analytical study is conducted to reveal that the optimal service level on the “fulfillment and responsiveness” function for the risk averse OSP uniquely exists. Moreover, the analytical results prove that (i) if the customer loyalty is more positively correlated to the service level, it will lead to a larger optimal service level, and (ii) the optimal service level is independent of the profit target, the source of uncertainty, and the risk preference of the OSP.
The crystal structure of keatite, a new form of silica (1959)

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Simulation of an ECS-based operating system (1967)

Extended Core Storage (ECS) for the Control Data 64/6600 System has been described in another paper. ECS is a large capacity, word-addressable core memory with block transfer times of from eight to ten words per microsecond after a transfer start-up time of approximately 2 microseconds. ECS memories range in size from 131K to over two million words, and can be shared by up to four 6000 systems. The cost per word of Extended Core Storage is about one-tenth that of Central Memory (CM).
The emulsion copolymerization of styrene and sodium styrene sulfonate (1985)

Abstract The emulsion copolymerization of styrene and sodium styrene sulfonate has been shown to be a feasible preparative route to ionomeric sulfonated polystyrene. The properties of these copolymers are reported elsewhere. The copolymerization rate was found to be dramatically enhanced when compared to that for the emulsion copolymerization of styrene under identical conditions. This copolymerization was studied in detail and two mechanisms were proposed to account for these rate differences. An increase in the number of polymerizing particles in the copolymerization with consequent rate enhancement was substantiated by electron microscopy. However, the data indicate that the rate differences cannot be fully accounted for by this effect. In addition, a gel effect is proposed as a second contributor to the enhanced rate. This gel effect is believed to result from the intermolecular association of the incorporated metal sulfonate units in the growing polymer particles. When a third monomer that plasticizes the ionic interactions is used the polymerization rate decreases. This supports the gel effect hypothesis.
Regioselective epoxidation of allylic alcohols with monoperoxyphthalic acid in water (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRegioselective epoxidation of allylic alcohols with monoperoxyphthalic acid in waterFrancesco Fringuelli, Raimondo Germani, Ferdinando Pizzo, Fabio Santinelli, and Gianfranco SavelliCite this: J. Org. Chem. 1992, 57, 4, 1198–1202Publication Date (Print):February 1, 1992Publication History Published online1 May 2002Published inissue 1 February 1992https://pubs.acs.org/doi/10.1021/jo00030a029https://doi.org/10.1021/jo00030a029research-articleACS PublicationsRequest reuse permissionsArticle Views1287Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A 1/4-inch 380 k pixel IT-CCD image sensor employing gate-assisted punchthrough read-out mode (1995)

A newly developed 1/4-inch 380 k pixel IT-CCD image sensor features a novel cell structure in which signal charges are read out from a photodiode (PD) to a vertical-CCD (V-CCD) in a gate-assisted punchthrough mode. The cell structure, fabricated through the use of high energy ion implantation technology, enables both deep PD formation and transfer-gate (TG)/channel-stop (CS) length reduction. Deep PD formation helps increase sensitivity per PD unit area, and TG/CS length reduction widens both PD and V-CCD areas. Although the cell size is small (4.8 /spl mu/m (H)/spl times/5.6 /spl mu/m (V)), the sensor achieves both high sensitivity (35 mV/lx) and a high saturation signal (600 mV).< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Survey of excitation signals for FFT based signal analyzers (1988)

The properties of ten different excitation signals are studied to analyze their suitability as excitation signals for fast Fourier transform (FFT)-based signal and network analyzers. Their influence on the measurement time, accuracy, and sensitivity to nonlinear distortions is described. The flexibility to create a customized amplitude spectrum is investigated. With this information it becomes possible to select the best excitation signal for many applications.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Application and Performance of 3D Printing in Nanobiomaterials (2013)

3D printing (3DP) is becoming a research and development focus in nanobiomaterials as it can quickly and accurately fabricate any desired 3D tissuemodel only if itssize is appropriate. The different material powders (with different dimensional scales) and the printing strategies are the most direct factors influencing 3DP quality. With the development of nanotechnologies, 3DP is adopted more frequently for its rapidness in fabrication and precision in geometry. The fabrication in micro/nanoscale may change the performance of biomaterials and devices because it can retain more anisotropy of biomaterials compared with the traditionally rapid prototyping techniques. Thus, the biosafety issue is especially concerned by many researchers and is investigated in performance and safety of biomaterials and devices. This paper investigates the performance of 3DP in fabrication of nanobiomaterials and devices so as to partially explain how 3DP influences the performance and safety of nanobiomaterials.
The effects of oral nifedipine on hepatic blood flow in humans (1991)

Duplex ultrasonography was used to measure changes in hepatic blood flow in 13 healthy volunteers after they received single doses of 10 mg oral nifedipine and placebo. Blood flow was measured in the hepatic artery and branches of the portal and hepatic veins at baseline and 0.3, 0.6, 1, 1.5, 2, 3, 4, and 5 hours after drug administration. Cardiac output was also measured at baseline and 1, 2, and 3 hours after dosing. Blood flow initially increased in all three vessels 0.6 hour after administration of nifedipine (29%, 56%, and 31% in the hepatic artery, hepatic vein, and portal vein, respectively) compared with placebo. Flow rapidly returned to baseline in the hepatic artery and hepatic vein, whereas it appeared to remain elevated through 3 hours in the portal vein. Nifedipine administration resulted in an increase in cardiac output of 26%, 22%, and 14% above placebo at 1, 2, and 3 hours, respectively. No significant differences were detected in the systolic, diastolic, or mean arterial blood pressures after nifedipine or placebo. This study demonstrates that nifedipine increases hepatic blood flow in a transient nature and systemic hemodynamic parameters do not necessarily reflect specific organ responses. The nifedipine-induced change in blood flow should be considered when nifedipine is coadministered with high-clearance drugs, because systemic availability may be increased.
Generalizing Word Lattice Translation (2008)

The Department of Defense (DoD) and civilian relief agencies (non-governmental organizations--
Purification of cloned proaerolysin released by a low protease mutant of <i>Aeromonas salmonicida</i> (1990)

The precursor to the hole-forming toxin aerolysin has been purified in high yield from culture supernatants of a mutant of Aeromonas salmonicida containing the cloned structural gene. The mutant strain was generated by Tn5 mutagenesis. It released little or no protease or other extracellular proteins, including phospholipase, suggesting that it is a regulatory mutant. The absence of protease allowed the isolation of protoxin free from contaminating aerolysin. Typically, more than 50 mg of pure proaerolysin was obtained from 2 L of culture supernatant. The purified protein was completely unable to lyse human erythrocytes without prior activation with trypsin.
Study of Die Cast Magnesium Components for Crash Safety (2002)

Abstract In this paper, AM60 magnesium die cast components are studied to understand material property variation, fracture behaviour and finite element simulation. The magnesium IP beam is selected for material characterization and fracture behaviour study. It is shown that maximum plastic strain of the component varies from 3% to 11% while the standard sample has 6% elongation. The material laws with failure criterion in Radioss Crash are studied to understand failure definitions and their mathematical forms for calculation. Specimens are tested and simulated under different loading conditions including standard coupon tension, wider specimen tension and dome forming test. It is found that failure strain obtained from standard tensile test cannot be used to predict failures in wider specimen tension and dome forming tests. The simulation underestimates the failure strains and overestimates the loading capacity of magnesium specimens. It requires a modification on material input to obtain good correlation...
A novel method for time series symbolization based on singular event features clustering (2010)

This Qualitative abstract representation of time series is a precondition of pattern discovery. A novel method for time series symbolization based on singular event features clustering is proposed in this paper. The first step of it is to extract singular event features based on multi-scale wavelet which can divide time series into event sequences with independent trend. Secondly, cluster the events that represented by transform parameters through the novel fuzzy immune genetic algorithm to implement symbolization. Each event is identified by the cluster it belongs to. The proposed method is applied to unstable financial time series symbolization. The proposed method can be used to discover significant similar patterns, classification and associated patterns from time series.
Molecular structure of .mu.-(9-methyladenine-N1,N7)-bis(di-isopropyl sulfoxide-S)-trans-dichloroplatinum(II) (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMolecular structure of .mu.-(9-methyladenine-N1,N7)-bis(di-isopropyl sulfoxide-S)-trans-dichloroplatinum(II)Colin J. L. Lock, Robert A. Speranzini, Graham Turner, and John PowellCite this: J. Am. Chem. Soc. 1976, 98, 24, 7865–7866Publication Date (Print):November 1, 1976Publication History Published online1 May 2002Published inissue 1 November 1976https://pubs.acs.org/doi/10.1021/ja00440a090https://doi.org/10.1021/ja00440a090research-articleACS PublicationsRequest reuse permissionsArticle Views41Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts