gebhart/patrepeval huggingface dataset:
Simple, semiautomatic assay of cytostatic and cytotoxic effects of antitumor drugs by laser scanning cytometry: Effects of the bis‐intercalator WP631 on growth and cell cycle of T‐24 cells (2003)

Because late apoptotic cells detach during culturing, the cells that remain attached in the multi-chamber cultures represent predominantly live cells; the deficit in their number compared with the untreated cultures, recorded by LSC during scanning, provides information about the degree of cytostatic and cytotoxic effects of the studied drug. The possibility to demonstrate the cell cycle distribution, including a distinction between G2 and M cells, provides an additional advantage of this assay. Other parameters that may be associated with the cell cycle perturbation or with induction of apoptosis also can be measured in the same cultures by using the multiparameter capabilities of LSC. Each measured cell can be relocated for imaging or measurement after subsequent staining with other probes.
Reflective shadow maps (2005)

In this paper we present "reflective shadow maps", an algorithm for interactive rendering of plausible indirect illumination. A reflective shadow map is an extension to a standard shadow map, where every pixel is considered as an indirect light source. The illumination due to these indirect lights is evaluated on-the-fly using adaptive sampling in a fragment shader. By using screen-space interpolation of the indirect lighting, we achieve interactive rates, even for complex scenes. Since we mainly work in screen space, the additional effort is largely independent of scene complexity. The resulting indirect light is approximate, but leads to plausible results and is suited for dynamic scenes. We describe an implementation on current graphics hardware and show results achieved with our approach.
Thermal annealing-induced enhancement of the field-effect mobility of regioregular poly(3-hexylthiophene) films (2006)

Polymer field-effect transistors with a field-effect mobility of μ≈0.3cm2s−1V−1 have been demonstrated using regioregular poly(3-hexylthiophene) (rr-P3HT). Devices were fabricated by dip coating the semiconducting polymer followed by annealing at 150°C for 10min. The heat annealed devices exhibit an increased field-effect mobility compared with the as-prepared devices. Morphology studies and analysis of the channel resistance demonstrate that the annealing process increases the crystallinity of rr-P3HT and improves the contact between the electrodes and the P3HT films, thereby increasing the field-effect mobility of the films.
Online Sequential Extreme Learning Machine for Vibration-Based Damage Assessment Using Transmissibility Data (2015)

Traditional vibration-based damage assessment approaches include the use of feed-forward neural networks. However, the slow learning speed of these networks and the large number of parameters that need to be tuned have been a major bottleneck in their application. This paper proposes to use an emergent learning algorithm called the online sequential extreme learning machine (OS-ELM) algorithm. This algorithm provides good generalization at fast learning speeds, allows data to be learned one by one or block by block, and the only parameter that needs to be tuned is the number of hidden nodes. A single-hidden-layer network is trained to detect, locate, and quantify structural damage using data derived from transmissibility measurements. Two experimental cases are presented to illustrate the approach: an eight-degree-of-freedom (DOF) mass-spring system and a beam under multiple damage scenarios. To demonstrate the potential of the proposed algorithm over existing ones, the obtained results are compared with those of a model updating approach based on parallel genetic algorithms.
Phase Transitions in the System BaTiO <sub>3</sub> —KnbO <sub>3</sub> (1967)

Solid solution formation in the system BaTiO 3 —KnbO 3 was established by X‐ray diffraction and dielectric measurements. Solid solutions with cubic symmetry were observed in the composition range from 4 to 90 mole % KnbO 3 at room temperature. The lattice parameter for the BaTiO 3 solid solutions increased with increasing KNbO 3 ; that for the KnbO 3 solid solutions decreased with the addition of BaTiO 3 . A distinct discontinuity in lattice parameter was observed at the composition containing about 65 mole % BaTiO 3 . Dielectric measurements were made from‐195° to 400°C. The cubic‐tetragonal transition temperature of BaTiO 3 was rapidly lowered with increasing addition of KNbO 3 , whereas the two lower phase transition temperatures were raised. All three phase transitions of KnbO 3 were rapidly lowered with increasing addition of BaTiO 3 . The observed phase transitions, lattice parameters, and electron probe data suggest a complex region in the subsolidus which extends from 35 to about 75 mole % KNbO 3 .
A Controlled Trial of Oral Rifampin in Chronic Plaque Psoriasis (2014)

Group A Streptococcal infection in the throat is responsible for causing initial and recurrent attacks of acute guttate psoriasis (AGP). Up to 70% of these AGP patients go on to develop chronic plaque psoriasis (CPP). We hypothe sized that chronic sub -clinical, on-going streptococcal infection might solelybe responsible for CPP in a genetically predisposed individual. Rifampin, a useful drug for several types of bacterial infections including Group A Streptococci (GAS) because obroad spectrum, excellent tissue penetration, low side -
Viscosimeter on a Microfluidic Chip (2006)

In this work, a viscosimeter implemented on a microfluidic chip is presented. The physical principle of this system is to use laminar parallel flows in a microfluidic channel. The fluid to be studied flows side by side with a reference fluid of known viscosity. By using optical microscopy, the shape of the interface between both fluids can be determined. Knowing the flow rates of the two liquids and the geometrical features of the channel, the mean shear rate sustained by the fluid and its viscosity can thus be computed. Accurate and precise measurements of the viscosity as a function of the shear rate can be made using less than 300 microL of fluid. Several complex fluids are tested with viscosities ranging from 10(-)(3) to 70 Pa.s.
Pharmacokinetic-pharmacodynamic interactions of candesartan cilexetil and losartan (1999)

The pharmacodynamic effects of a single oral dose of 16 mg candesartan cilexetil are greater than those of 50 mg losartan and 8 mg candesartan cilexetil. The variability in the pharmacokinetic-pharmacodynamic interaction is less pronounced for candesartan than for EXP 3174, which could result in reduced variability of the blood pressure effects in patients.
Reductive dehalogenation of 2,4-dihalogeno estrogens having a 3-hydroxy substituent by formic acid, potassium iodide, or ascorbic acid (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReductive dehalogenation of 2,4-dihalogeno estrogens having a 3-hydroxy substituent by formic acid, potassium iodide, or ascorbic acidMitsuteru Numazawa, Katsuhiko Kimura, Mieko Ogata, and Masao NagaokaCite this: J. Org. Chem. 1985, 50, 25, 5421–5423Publication Date (Print):December 1, 1985Publication History Published online1 May 2002Published inissue 1 December 1985https://pubs.acs.org/doi/10.1021/jo00225a095https://doi.org/10.1021/jo00225a095research-articleACS PublicationsRequest reuse permissionsArticle Views284Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A team effort (2002)

One of the overriding challenges of modern health care is to create systems that function in a coherent and seamless way to address the complex emotional, social, psychological and pathological problems with which patients present. While demand is creating a need for organisational reform, considerable attention is being given to undergraduate programmes that will develop professionals who can co-exist in the delivery of effective health care.
The Effect of N-Donor Ligands on the Reaction of Ruthenium Hydrides with 1-Alkynes (1997)

Neutral ruthenium hydrides Ru(CO)ClH(L)(PPh3)2 bearing one N-donor ligand react with 1-alkynes at 23 °C to yield neutral alkenyl complexes Ru(CO)Cl(CHCHR)(L)(PPh3)2. Under similar conditions, cationic hydrido complexes [Ru(CO)H(L)2(PPh3)2]PF6 with pyridine-type N-donor ligands yield alkynyl complexes [Ru(CO)(CH≡CHR)(L)2(PPh3)2]PF6 as a result of the reaction of the intermediate labile alkenyl with a second molecule of alkyne. Under more forcing conditions, 1-alkynyl complexes could also be prepared from the neutral ruthenium hydrides. Cationic ruthenium hydrides with bidentate N-donor ligands are unreactive toward 1-alkynes. Neutral alkenyl complexes Ru(CO)Cl(CHCHR)(L)(PPh3)2 (R = p-MeC6H4, CMe3; L = pyridine, isoquinoline) reacted smoothly with 1-alkynes to afford the corresponding σ-alkynyl ruthenium derivatives Ru(CO)Cl(C≡CR)(L)(PPh3)2.
Behavioural effects of a neem insecticide on<i>Coptotermes formosanus</i>(Isoptera: Rhinotermitidae) (1992)

Abstract The neem tree, Azadirachta indica is the source of azadirachtin and other compounds with potent insecticidal, feeding deterrent, and insect growth regulator activity. This study investigated the effects of a commercial insecticide formulation (Margosan‐O) containing 0.3% azadirachtin and 14% neem oil on orientation, tunnelling, and feeding behaviour of the Formosan subterranean termite, Coptotermes formosanus. In short‐term orientation assays, termite workers did not avoid papers treated with a 1000 ppm solution of azadirachtin. Termite workers also readily penetrated sand containing 20, 100, or 500 ppm azadirachtin, although significant mortality occurred in the 100 ppm treatment. However, subsequent observations indicated that termites avoided long‐term contact with the treated sand. In two multiple‐choice feeding assays, C. formosanus workers fed significantly less on papers containing azadirachtin concentrations >100 ppm. Azadirachtin, and possibly other neem oil components, thus show some toxicity, long‐term repellency, and feeding deterrent activity towards C. formosanus although the threshold for antifeedant effects is relatively high in comparison to thresholds for other insect species.
CENet: A Cabinet Environmental Sensing Network (2010)

For data center cooling and intelligent substation systems, real time cabinet environmental monitoring is a strong requirement. Monitoring data, such as temperature, humidity, and noise, is important for operators to manage the facilities in cabinets. We here propose a sensing network, called CENet, which is energy efficient and reliable for cabinet environmental monitoring. CENet achieves above 93% reliable data yield and sends fewer beacons compared to periodic beaconing. It does so through a data-aided routing protocol. In addition, based on B-MAC, we propose a scheduling scheme to increase the lifetime of the network by reducing unnecessary message snooping and channel listening, thus it is more energy efficient than B-MAC. The performance of CENet is evaluated by simulations and experiments.
Comparative analysis of exciting current harmonics and reactive power consumption from GIC saturated transformers (2002)

Geomagnetically induced currents (GIC) can cause severe transformer half-cycle saturation. This paper introduces a simplified method based on the equivalent magnetizing curve of the transformer to estimate harmonic currents and MVAr with only the given the GIC and nameplate and core design information of the transformer. The simulation method is validated with the field results. The simulation methods are validated with observational and field test data for transformers experiencing half-cycle saturation.
Presence of Hoechst low side populations in multiple myeloma (2008)

Multiple myeloma (MM) is an incurable B cell malignancy characterised by the accumulation of monoclonal plasma cells in the bone marrow and the presence of high level of monoclonal immunoglobulin i...
Development of A Personal Computer-Based Industrial Accident Information Management System: AIMS (1989)

In this study, we have developed the personal computer-based industrial accident information management system(AIMS) which produces the industrial accident reports, various statistical reports and graphic charts such as pie, bar and trent charts. Recognizing the fact that computer systems are an integral part of today's business environment, the computerized industrial accident information management system serves as tools to help safety professionals accurately and rapidly obtain the information necessary to make decisions. The system can be used for the prevention of industrial accidents by early detection of potential hazards and by scientific and systematic analysis of causal factors.
Imaging PD-L1 Expression with ImmunoPET (2017)

High sensitivity imaging tools could provide a more holistic view of target antigen expression to improve the identification of patients who might benefit from cancer immunotherapy. We developed for immunoPET a novel recombinant human IgG1 (termed C4) that potently binds an extracellular epitope on human and mouse PD-L1 and radiolabeled the antibody with zirconium-89. Small animal PET/CT studies showed that <sup>89</sup>Zr-C4 detected antigen levels on a patient derived xenograft (PDX) established from a non-small-cell lung cancer (NSCLC) patient before an 8-month response to anti-PD-1 and anti-CTLA4 therapy. Importantly, the concentration of antigen is beneath the detection limit of previously developed anti-PD-L1 radiotracers, including radiolabeled atezolizumab. We also show that <sup>89</sup>Zr-C4 can specifically detect antigen in human NSCLC and prostate cancer models endogenously expressing a broad range of PD-L1. <sup>89</sup>Zr-C4 detects mouse PD-L1 expression changes in immunocompetent mice, suggesting that endogenous PD-1/2 will not confound human imaging. Lastly, we found that <sup>89</sup>Zr-C4 could detect acute changes in tumor expression of PD-L1 due to standard of care chemotherapies. In summary, we present evidence that low levels of PD-L1 in clinically relevant cancer models can be imaged with immunoPET using a novel recombinant human antibody.
Kassieren (1980)

Diese Lerneinheit (24) vermittelt Ihnen das Wissen und das sich darauf stützende Verständnis zu folgenden Themen:
Characterization of gas chromatography of alkoxides of aluminum and of some Group IV elements (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCharacterization of gas chromatography of alkoxides of aluminum and of some Group IV elementsLawrence Milton. Brown and K. S. MazdiyasniCite this: Anal. Chem. 1969, 41, 10, 1243–1250Publication Date (Print):August 1, 1969Publication History Published online1 May 2002Published inissue 1 August 1969https://pubs.acs.org/doi/10.1021/ac60279a023https://doi.org/10.1021/ac60279a023research-articleACS PublicationsRequest reuse permissionsArticle Views137Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Enzyme Biosensors for Biomedical Applications: Strategies for Safeguarding Analytical Performances in Biological Fluids (2016)

Enzyme-based chemical biosensors are based on biological recognition. In order to operate, the enzymes must be available to catalyze a specific biochemical reaction and be stable under the normal operating conditions of the biosensor. Design of biosensors is based on knowledge about the target analyte, as well as the complexity of the matrix in which the analyte has to be quantified. This article reviews the problems resulting from the interaction of enzyme-based amperometric biosensors with complex biological matrices containing the target analyte(s). One of the most challenging disadvantages of amperometric enzyme-based biosensor detection is signal reduction from fouling agents and interference from chemicals present in the sample matrix. This article, therefore, investigates the principles of functioning of enzymatic biosensors, their analytical performance over time and the strategies used to optimize their performance. Moreover, the composition of biological fluids as a function of their interaction with biosensing will be presented.
Camera calibration from surfaces of revolution (2003)

This paper addresses the problem of calibrating a pinhole camera from images of a surface of revolution. Camera calibration is the process of determining the intrinsic or internal parameters (i.e., aspect ratio, focal length, and principal point) of a camera, and it is important for both motion estimation and metric reconstruction of 3D models. In this paper, a novel and simple calibration technique is introduced, which is based on exploiting the symmetry of images of surfaces of revolution. Traditional techniques for camera calibration involve taking images of some precisely machined calibration pattern (such as a calibration grid). The use of surfaces of revolution, which are commonly found in daily life (e.g., bowls and vases), makes the process easier as a result of the reduced cost and increased accessibility of the calibration objects. In this paper, it is shown that two images of a surface of revolution will provide enough information for determining the aspect ratio, focal length, and principal point of a camera with fixed intrinsic parameters. The algorithms presented in this paper have been implemented and tested with both synthetic and real data. Experimental results show that the camera calibration method presented is both practical and accurate.
Reflective Crosstalk Cancellation in Self-Seeded WDM PON for Mobile Fronthaul/Backhaul (2015)

Due to its large capacity and low latency, wavelength-division-multiplexed passive optical network (WDM PON) using self-seeded reflective semiconductor optical amplifier (RSOA) is an attractive, low-cost solution for mobile fronthaul/backhaul. However, multiple reflections in self-seeding cavity lead to reflective crosstalk, degrading its transmission performance. In this paper, reflective crosstalk in self-seeded RSOA under different bias conditions is experimentally characterized by its pulse response, and then novel feedforward and feedback approaches are proposed to suppress the reflective crosstalk in self-seeded WDM PON. Experimental results using a simple delay and differentiation method show significant reduction in the reflective crosstalk for self-seeded RSOA. With the proposed feedforward crosstalk cancellation, 2.5-Gb/s mobile backhaul using self-seeded RSOA achieves 1.7-dB performance improvement after transmission over 20-km single-mode fiber. In addition, low-cost bandwidth-efficient mobile fronthaul for 24 20-MHz LTE signals is demonstrated using a self-seeded RSOA with only 1.5-GHz bandwidth. With adaptive feedback crosstalk cancellation, the error vector magnitude for the received LTE signal after 20-km standard single-mode fiber transmission in the C-band is improved by 20%.
Synthesis of Novel Phosphonopeptides Derived from Pyridylmethylphosphonate Diphenyl Esters (2001)

Abstract A series of dipeptides derived from 2-pyridyl- and 3-pyridylmethyl-phosphonic diphenyl esters were synthesized. These dipeptides were obtained in the reaction of the diphenyl 2-pyridylmethyl(amino) phos-phonate or diphenyl 3-pyridylmethyl-(amino)phosphonate with the corresponding Z-blocked aminoacids (alanine, valine, and proline) by the DCC coupling method.
Features of Macrophage Differentiation Induced by p19INK4d, a Specific Inhibitor of Cyclin D–Dependent Kinases (1997)

The mitogen-dependent induction of cyclin D–dependent kinase activity is required for cells to enter the DNA synthetic (S) phase of their division cycle. Immature 32Dcl3 myeloid cells (32D) proliferating in the presence of interleukin-3 (IL-3) normally express cyclins D2 and D3, which assemble into binary holoenzyme complexes with their catalytic subunits, CDK4 and CDK6. When 32D cells are switched to medium containing granulocyte colony-stimulating factor (G-CSF ) instead of IL-3, D-type cyclins are degraded and, in the absence of their associated kinase activity, the cells arrest in the first gap phase (G1 ) of the cell cycle and differentiate to neutrophils. We derived 32D cells in which the expression of p19INK4d, a specific polypeptide inhibitor of CDK4 and CDK6, is regulated by the heavy metal-inducible sheep metallothionein promoter. Induction of p19INK4d in response to zinc prolonged cell survival in the absence of growth factor treatment. When maintained in medium containing both IL-3 and zinc, these cells lost cyclin D–dependent kinase activity, underwent G1 phase arrest, and acquired certain morphologic, antigenic, and functional properties of mononuclear phagocytes. Cells induced to express p19INK4d did not synthesize receptors for macrophage colony-stimulating factor (M-CSF/CSF-1) and reverted to an immature myeloid phenotype when shifted back into medium containing IL-3 alone. These cells exhibited accelerated differentiation to neutrophils in response to G-CSF but also gave rise to macrophage-like cells when maintained in medium containing both G-CSF and zinc. Therefore, the acquisition of macrophage properties in response to zinc treatment neither depended upon IL-3 nor upon G1 phase arrest per se and instead reflects some ability of p19INK4d, and presumably cyclin D–dependent kinases, to affect myeloid differentiation.
Study on Cloud Storage System Based on Distributed Storage Systems (2010)

As the latest development of the distributed storage technology, Cloud storage is the product of the integration of distributed storage and virtual technologies. Cloud storage is a method that allows you to use storage facilities available on the Internet. Relative to the current Commercial cloud storage file systems, introducing P2P network of interest groups put forward the idea of a P2P model based on cloud storage online backup prototype system, and the prototype system architecture and topology analysis, research and development for the following provide a theoretical basis.