gebhart/patrepeval huggingface dataset:
Characterization and spectral equalization for hight-density disk recording (1979)

For a 3350 type head/disk interface, the amplitude spectrum of an experimental characteristic pulse deviates slightly from the idealized Lorentzian distribution in the signal bandwidth; but the phase spectrum of the experimental pulse is quite distorted from the desired linear phase, causing the widely observed asymmetrical time-domain waveform. A quantitative characterization and comparison are presented and individual transfer functions for ideal linear equalization are proposed. To remove the intersymbol interference, i.e., the linear portion of the distortion, from the playback signal of a high-density system, several cosine-power-law spectral candidates, with minimized noise enhancement and the capability of restoring amplitude loss and timing error, are explored. A unified relationship for the entire family of cosine-power-law spectral shapes and their bandwidth tradeoffs are identified, allowing for optimum read equalization at a tolerable signal-to-noise penalty. This is a useful tool for exploring practical density limitations of any given head/disk interface.
Three dimensional circuit oriented electromagnetic modeling for VLSI packaging (1992)

Summary form only given. Circuit-oriented approaches for the solution of interconnect problems were considered. Issues for partial element equivalent circuit modeling, such as retardation and dielectrics, were examined. This corresponds to a full wave electromagnetic solution of the problem. A further issue discussed was potential circuit solver methods for the solution of these problems. The solution of these problems is very time consuming due to the couplings, and exact as well as approximate solution techniques may be appropriate in some cases.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Servicios web, Social Media y SEO (2013)

?Tu web no te gusta o esta anticuada? ?Esta optimizada para SEO? ?Tienes presencia en redes sociales? Mejora tu notoriedad online y tu visibilidad.
Visions image operating system (1982)

The image operating system is a complete software environment specifically designed for dynamic experimentation in scene analysis. The IOS consists of a high-level interpretive control language (LISP) with efficient image operators in a noninterpretive language. The image operators are viewed as local operators to be applied in parallel at all pixels to a set of input images. In order to carry out complex image analysis experiments an environment conducive to such experimentation was needed. This environment is provided by the visions image operating system based on a computational structure known as a processing cone proposed by Hanson and Riseman (1974, 1980) and implemented on a VAX-11/780 running VMS. 6 references.
Solid-State<sup>25</sup>Mg NMR Study of Inner-Sphere Mg<sup>2+</sup>Binding Complexes (1999)

A solid-state 25Mg NMR study is reported for four magnesium complexes with typical inner-sphere Mg2+ binding environments. The first 25Mg multiple quantum magic-angle spinning (MQMAS) experiment is demonstrated, which improves the resolution by approximately 20-fold.
Ubiquitin‐dependent proteolysis in mammalian spermatogenesis, fertilization, and sperm quality control: Killing three birds with one stone (2003)

Ubiquitin and ubiquitin-like proteins control the degradation of substrates as diverse as cyclins, viral envelope proteins, plasma membrane receptors, and mRNAs. The ubiquitinated substrates are targeted towards the lysosomal or proteasomal degradation sites. The number and position of ubiquitin molecules bound to substrates' lysine residues and the number and position of ubiquitin molecules in polyubiquitin chains determine the astonishing substrate specificity of ubiquitin-mediated proteolysis. Ubiquitin is likely to be expressed in mammalian gametes and embryos at any given developmental step, but the information on ubiquitin dependence of gametogenesis and fertilization is sketchy. Ubiquitin ligases E1, E2, E3, and UBC4 are active in the testis. Ubiquitin and proteasomal subunits can be detected in the human sperm centrosome that undergoes dramatic reduction during spermatid elongation. Spermatid histones are ubiquitinated as they are being transiently replaced by transitional proteins and permanently by protamines. Ubiquitin tagging of the sperm mitochondrial membranes may serve as a death sentence for paternal mitochondria at fertilization, thus promoting the maternal inheritance of mitochondrial DNA (mtDNA) in mammals. The defective spermatozoa become surface-ubiquitinated during sperm descent down the epididymis. Finally, new evidence suggests the involvement of ubiquitin-proteasome pathway in the zona penetration by the acrosome-reacted spermatozoon. Such differential patterns of ubiquitination in the testis and epididymis, and inside the egg, may be necessary for reproductive success in humans and animals. Deciphering and eventually manipulating the ubiquitin-dependent proteolysis in the reproductive system could allow us to redirect the mode of mtDNA inheritance after cloning and ooplasmic transplantation, provide germ line therapy in some cases of male infertility, develop new contraceptives, manage polyspermia during in vitro fertilization, and establish objective markers for infertility diagnostics, semen evaluation, and prediction of future fertility.
Importance of venodilatation in prevention of left ventricular dilatation after chronic large myocardial infarction in rats: a comparison of captopril and hydralazine. (1989)

In rats with large myocardial infarctions, we compared the effects of captopril, a presumed arterial and venous vasodilator, with hydralazine, which is thought primarily to be an arterial vasodilator. To determine if the effects of captopril were dependent on the pathophysiological consequences of heart failure, we also studied a group of noninfarcted rats treated with captopril. In noninfarcted rats treated with captopril, left ventricular (LV) systolic and mean aortic pressures decreased from 132 +/- 12 to 107 +/- 15 mm Hg and 122 +/- 1 to 100 +/- 2, respectively (p less than 0.01). In noninfarcted rats, captopril decreased LV weight, LV weight/body weight, and total heart weight/body weight but produced no effects on the peripheral venous circulation. Rats subjected to coronary artery ligation were selected by ECG criteria to have large myocardial infarctions and were treated for 4 weeks with captopril (n = 8), hydralazine (n = 5), or placebo (n = 9). In infarcted rats treated with captopril, LV systolic, mean aortic pressures and LV end-diastolic pressure (LVEDP) decreased (p less than 0.01) from 115 +/- 4 to 86 +/- 3 mm Hg, 106 +/- 4 to 74 +/- 3 mm Hg, and 23 +/- 2 to 11 +/- 2 mm Hg, respectively. Mean circulatory filling pressure decreased (p less than 0.05) from 11.2 +/- 0.6 to 8.7 +/- 0.8 mm Hg and venous compliance increased (p less than 0.05) from 2.04 +/- 0.07 to 2.70 +/- 0.20 ml/mm Hg/kg. Blood volume decreased (p less than 0.05) from 67.3 +/- 0.9 to 58.2 +/- 1.8 ml/kg.(ABSTRACT TRUNCATED AT 250 WORDS)
The basal rate of cell proliferation in normal human parathyroid tissue: implications for the pathogenesis of hyperparathyroidism (1997)

(1) Our results establish the human parathyroid gland as a conditionally renewing tissue with very low basal cell-birth rate; other reports of much higher LI values are probably due to selective and consequently biased sampling. (2) Since the total number of cell divisions is a major determinant of the total number of mutations, our results place some constraints of possible mechanisms for parathyroid neoplasia.
Context-Aware Campaigns in Social Networks (2010)

Services have become increasingly important in today's Web-based applications. Users can access services in an anytime, anywhere manner using a wide variety of mobile devices. Mobile services are a key driver in today's telecommunication market, even though the potential of mobile services has not been fully exploited in existing telecommunication systems. A main driver in these markets are context- aware services to build intuitive services for mobile handsets. One success factor is to support a broad range of handsets available on the market and making the services context- aware by obtaining contextual information. Context may be derived from information obtained from the handset - most prominently location information. In this work, we present a mobile marketing platform enabling the advertisement of services in mobile markets. Advertisements and offerings need to be customized based on user preferences. We propose a recommendation approach of services based on social-network properties and human provided services. Our contributions are the Woodapples platform offering a set of APIs for creating mobile campaigns and an approach for managing social and service network structures in a unified manner.
Segment-based video coding using an affine motion model. (1994)

This paper describes a segment-based motion compensation (MC) method where object motion is described using an affine motion model. In the proposed MC method, the shape of the objects is obtained using 5D K-mean clustering (employing three color components and two coordinates). Motion estimation and compensation employing the affine motion model are performed on each arbitrarily shaped object in the current frame. By using the affine motion model, rotation and scaling of objects can be compensated for in addition to translational motion. The residual between the current frame and the predicted one is DCT-coded and multiplexed with the motion and shape parameters. Simulation results show that the interframe prediction error is significantly reduced compared to the conventional block-based method. The SNR of the coded sequences obtained using the proposed method (modified MPEG1 with segment-based affine MC) is about 0.8 - 2 dB higher than that using the conventional one (original MPEG1 with block-based MC).© (1994) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
Cytokines and the pathogenesis of myasthenia gravis (1997)

Myasthenia gravis (MG) and its animal model experimental autoimmune myasthenia gravis (EAMG) are caused by autoantibodies against nicotinic acetylcholine receptor (AChR) in skeletal muscle. The production of anti-AChR antibodies is mediated by cytokines produced by CD4+ and CD8+ T helper (Th) cells. Emerging investigations of the roles of cytokines in MG and EAMG have revealed that the Th2 cell related cytokine interleukin 4 (IL-4), an efficient growth promoter for B-cell proliferation and differentiation, is important for anti-AChR antibody production. IL-6 and IL-10 have similar effects. The Th1 cytokine IFN-γ is important in inducing B-cell maturation and in helping anti-AChR antibody production and, thereby, for induction of clinical signs and symptoms. Results from studies of time kinetics of cytokines imply that IFN-γ is more agile at the onset of EAMG, probably being one of the initiating factors in the induction of the disease, and IL-4 may be mainly responsible for disease progression and persistance. Even though other Th1 cytokines like IL-2, tumor necrosis factor α (TNF-α), and TNF-β as well as the cytolytic compound perforin do not directly play a role in T-cell-mediated help for anti-AChR antibody production, they are actually involved in the development of both EAMG and MG, probably by acting in concert with other cytokines within the cytokine network. In contrast, transforming growth factor β (TGF-β) exerts immunosuppressive effects which include the down-regulation of both Th1 and Th2 cytokines in MG as well as EAMG. Suppressive effects are also exerted by interferon α (IFN-α). Based on elucidation of the role of cytokines in EAMG and MG, treatments that up-modulate TGF-β or IFN-α and/or suppress cytokines that help B-cell proliferation could be useful to improve the clinical outcome. © 1997 John Wiley & Sons, Inc. Muscle Nerve, 20, 543–551, 1997
Eicosapentaenoic acid inhibits UV-induced MMP-1 expression in human dermal fibroblasts (2005)

Ultraviolet (UV) irradiation regulates UV-responsive genes, including matrix metalloproteinases (MMPs). Moreover, UV-induced MMPs cause connective tissue damage and the skin to become wrinkled and aged. Here, we investigated the effect of eicosapentaenoic acid (EPA), a dietary omega-3 fatty acid, on UV-induced MMP-1 expression in human dermal fibroblasts (HDFs). We found that UV radiation increases MMP-1 expression and that this is mediated by p44 and p42 MAP kinase (ERK) and Jun-N-terminal kinase (JNK) activation but not by p38 activation. Pretreatment of HDFs with EPA inhibited UV-induced MMP-1 expression in a dose-dependent manner and also inhibited the UV-induced activation of ERK and JNK by inhibiting ERK kinase (MEK1) and SAPK/ERK kinase 1 (SEK1) activation, respectively. Moreover, inhibition of ERK and JNK by EPA resulted in the decrease of c-Fos expression and c-Jun phosphorylation/expression induced by UV, respectively, which led to the inhibition of UV-induced activator protein-1 DNA binding activity. This inhibitory effect of EPA on MMP-1 was not mediated by an antioxidant effect. We also found that EPA inhibited 12-O-tetradecanoylphorbol-13-acetate- or tumor necrosis factor-alpha-induced MMP-1 expression in HDFs and UV-induced MMP-1 expression in HaCaT cells. In conclusion, our results demonstrate that EPA can inhibit UV-induced MMP-1 expression by inhibiting the MEK1/ERK/c-Fos and SEK1/JNK/c-Jun pathways. Therefore, EPA is a potential agent for the prevention and treatment of skin aging.
Layered polyelectrolyte complexes: physics of formation and molecular properties (2003)

Multilayers of charged polymers can be formed by the alternating adsorption of polyanions and polycations. By this so-called layer-by-layer self-assembly method, planar surfaces or colloidal templates can be coated. This method is reviewed here with respect to the basic physical principles governing multilayer formation. Particular emphasis is put on the adsorption process of a single polyelectrolyte layer to a multilayer surface as the process controlling the charge complexation and the local molecular structure. Then, the implications for the properties of the multilayer assembly are discussed. In particular, molecular properties such as the internal stoichiometry, the local interactions, and the conformation on a molecular scale are reviewed.
[99mTcOAADT]-(CH2)2-NEt2: A Potential Small-Molecule Single-Photon Emission Computed Tomography Probe for Imaging Metastatic Melanoma (2005)

Evaluation of [99mTc]oxotechnetium(V) complexes of the amine-amide-dithiol (AADT) chelates containing tertiary amine substituents as small-molecule probes for the diagnostic imaging of metastatic melanoma has shown that technetium-99m-labeled AADT-(CH2)2-NEt2 (99mTc-1) has the highest tumor uptake and other favorable biological properties. We have, therefore, assessed this agent in a more realistic metastatic melanoma model in which, after i.v. tail injection, a highly invasive melanoma cell line, B16F10, forms pulmonary tumor nodules in normal C57BL6 mice. Small melanotic lesions develop in the lungs and, on histologic examination, appear as small black melanoma colonies, increasing in size and number with time after tumor cell injection. Groups of mice received tumor cell inocula of 2 x 10(5), 4 x 10(5), or 8 x 10(5) B16F10 cells; 14 days later, 2 hours after 99mTc-1 administration, lung uptake of 2.83 +/- 0.21%, 3.63 +/- 1.07%, and 4.92 +/- 1.61% injected dose per gram of tissue (% ID/g), respectively, was observed, compared with normal lung uptake of 2.13 +/- 0.2% ID/g (P < 0.05). Additionally, a higher level of 99mTc-1 accumulation was seen 17 days after tumor cell inoculation as the lung lesions grew. These in vivo studies coupled with additional in vitro and ex vivo assessment show that 99mTc-1 has high and specific uptake in melanoma metastases in lungs and can potentially follow the temporal growth of these tumors.
Development of adaptive mirror for wavefront correction of hard x-ray nanobeam (2008)

We present the development of a phase compensator for wavefront control of X-rays. The optical device is a 150 mm-long total reflection mirror, the shape of which can be curved by adjusting the bias voltages of 36 piezoelectric ceramic plates attached to the mirror. The mirror surface was smoothed and made flat by elastic emission machining. To achieve a high degree of the accuracy in the controllability of a curved line, a Fizeau interferometer is placed in front of the mirror surface to monitor its shape in the experiment. We will apply this device to the optical system for the realization of sub-10-nm hard X-ray focusing.
Security versus performance bugs (2011)

A good understanding of the impact of different types of bugs on various project aspects is essential to improve software quality research and practice. For instance, we would expect that security bugs are fixed faster than other types of bugs due to their critical nature. However, prior research has often treated all bugs as similar when studying various aspects of software quality (e.g., predicting the time to fix a bug), or has focused on one particular type of bug (e.g., security bugs) with little comparison to other types. In this paper, we study how different types of bugs (performance and security bugs) differ from each other and from the rest of the bugs in a software project. Through a case study on the Firefox project, we find that security bugs are fixed and triaged much faster, but are reopened and tossed more frequently. Furthermore, we also find that security bugs involve more developers and impact more files in a project. Our work is the first work to ever empirically study performance bugs and compare it to frequently-studied security bugs. Our findings highlight the importance of considering the different types of bugs in software quality research and practice.
Burner survey for a high efficiency gas-fired heating unit. Final report November 1983-January 1984 (1984)

A survey was undertaken to evaluate the suitability of a variety of burner types for use in a new concept, high efficiency residential hydronic heating unit. Emphasis was placed on radiant systems that are currently commercially available. Nine different burner types were reviewed and evaluated against criteria established by the hydronic heating unit manufacturer. Results of the survey show that a porous fiber matrix burner can most easily be incorporated into the heating unit design and meet the operational criteria.
Using adaptive optics for deep in-vivo multiphoton FLIM (2011)

Multiphoton microscopy (MPM) is a high resolution (sub-μm) 3D optical imaging technique that has seen widespread use for microscopy at moderate depth within biological tissue (~1 mm). MPM combined with Fluorescence lifetime imaging (FLIM) and Fluorescent resonant energy transfer (FRET) provides the ability to image protein-protein interactions. When applied in-vivo at depth, it will be a key component to identifying and evaluating drug interaction in tumours. Unfortunately as one images more deeply into biological tissue, depth is restricted due to the specimen induced aberrations, which result in deterioration in both the image quality and resolution. Adaptive optics (AO), a technique first developed for astronomy, has been shown to be successful in overcoming problems associated with imaging in depth in confocal, multiphoton, CARS and SHG microscopy. The principle relies on shaping the wavefront with a wavefront modulator to compensate for the distortions introduced by the biological tissue sample. The success of such a technique relies on being able to correctly determine the mirror shape required In this paper we will discuss the development a dedicated MPM FLIM-FRET microscope incorporating an AO for use in-vivo applications. Using a deformable membrane mirror as a wavefront modulator, a strategy for implementation will be discussed.
Spatially resolved differential resistance of bulk superconductors by laser-induced heating (1990)

Spatially resolved measurements of the change in resistance with temperature of bulk high-temperature superconductors are generated by heating a localized region of a sample with a modulated laser beam. The amplitude of the thermally induced resistance change is related to the heat capacity and derivative of resistance with temperature whereas the phase of the signal is related to the thermal diffusivity of the sample. By moving the sample with respect to the focused laser beam, spatially resolved measurements may be made. Images with ∼50-μm resolution have been used to locate defects in polycrystalline Bi-Sr-Ca-Cu-O sample and to estimate the thermal diffusivity of the bulk material.
A single amino acid change (Y318F) in the L-arabitol dehydrogenase (LadA) from Aspergillus niger results in a significant increase in affinity for D-sorbitol (2009)

These data demonstrates that Y318 of LadA contributes significantly to the substrate specificity difference between LAD and XDH/SDH.
Monitoring Cellular Responses to Listeria monocytogenes with Oligonucleotide Arrays (2000)

Listeria monocytogenes is a pathogenic intracellular microorganism whose infection induces pleiotropic biological changes associated with host cell gene expression regulation. Here we define the gene expression profiles of the human promyelocytic THP1 cell line before and after L. monocytogenes infection. Gene expression was measured on a large scale via oligonucleotide microarrays with probe sets corresponding to 6,800 human genes. We assessed and discussed the reproducibility of the hybridization signatures. In addition to oligonucleotide arrays, we also performed the large scale gene expression measurement with two high-density membranes, assaying for 588 and 18,376 human genes, respectively. This work allowed the reproducible identification of 74 up-regulated RNAs and 23 down-regulated RNAs as a consequence of L. monocytogenes infection of THP1. The reliability of these data was reinforced by performing independent infections. Some of these detected RNAs were consistent with previous results, while some newly identified RNAs encode gene products that may play key roles in L. monocytogenes infection. These findings will undoubtedly enhance the understanding of L. monocytogenes molecular physiology and may help identify new therapeutic targets.
Fabrication of long-period fiber gratings by focused irradiation of infrared femtosecond laser pulses (1999)

We have fabricated long-period fiber gratings by use of a novel technique using focused irradiation of infrared femtosecond laser pulses. We investigate the thermal stability of the fabricated fiber gratings. The values of the loss peak wavelength and the transmittance of the fiber gratings after heat treatment below 500 degrees C are the same as initial values before heat treatment. The fiber gratings that were fabricated by this technique have a high resistance to thermal decay. We propose that this technique will be useful for fabrication of fiber gratings with a superior aging characteristic.