gebhart/patrepeval huggingface dataset:
Naphthenic Acids from Gulf Coast Petroleum COMPOSITION OF HIGHER BOILING ACIDS (1940)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNaphthenic Acids from Gulf Coast Petroleum COMPOSITION OF HIGHER BOILING ACIDSRoy W. Harkness and Johannes H. BruunCite this: Ind. Eng. Chem. 1940, 32, 4, 499–502Publication Date (Print):April 1, 1940Publication History Published online1 May 2002Published inissue 1 April 1940https://pubs.acs.org/doi/10.1021/ie50364a012https://doi.org/10.1021/ie50364a012research-articleACS PublicationsRequest reuse permissionsArticle Views35Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
A phase II study of capecitabine and concomitant boost radiotherapy (XRT) in patients (pts) with locally advanced rectal cancer (LARC) (2005)

3593 Background: Preoperative radiotherapy with continuous infusional 5-fluorouracil (CI-5FU) improves sphincter preservation and produces pathological complete remissions (pCR) in 10–30% of patients (pts) with LARC. Capecitabine (Xeloda), an oral fluoropyrimidine, is preferentially converted to 5-FU by high intra-tumor thymidine phosphorylase that can be further activated by radiotherapy. Design: The primary endpoint of this phase II study is to evaluate the rate of pathological response with secondary endpoints on survival, recurrence, quality of life, and tumor markers. Capecitabine (825 mg/m2 PO bid/7days during XRT was administered with concomitant boost XRT (52.5 Gy/30 fractions to the primary/perirectal nodes, and 45Gy to the pelvis) in 54 pts with LARC (≥ T3N0 or any T/N1 staged by EUS). Eligible patients recieved capecitabine 1250 mg/m2 PO bid day 1–14 every 21 for four cycles as adjuvant treatment after surgery. Results: Pts characteristics included median age: 56 (36–78), male:female ratio: 1.7; ECOG performance status 0–1 100%; 42 pts (92%) had T3N0 or T3N1 disease. The pathological response of the 44 patients who underwent resection to date includes 7 pts (16%) who achieved pCR and 28 pts (64%) had a partial response resulting in a 79% overall response rate. Stable disease was evident in 5 pts (11%) and 2 pts (5%) had progressive disease. Two pts (5%) who achieve complete clinical remissions refused surgery. Most toxicities were Grade 1/2: hand foot syndrome (27%), diarrhea (25%), fatigue (21%), leukopenia (15%), anemia (15%), and proctitis (10%). Gr 3 toxicities were limited: diarrhea (10%) and radiation dermatitis (6%), bilirubinemia (4%) and hand and foot syndrome (2%). Gr 4 diarrhea occurred only in one pt. Conclusion: Concomitant boost radiotherapy plus capecitabine is very well tolerated and produces pathological response rates that are comparable to CI-5FU for LARC. Capecitabine also avoids the discomfort and potential complications, like infection and phlebitis, associated with CI-5FU. Full report will be presented at the meeting. *Study supported by Roche Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Norvartis, Pfizer, Roche Norvartis, Roche
The proposed smart transducer interface standard (2002)

A proposed smart transducer interface standard P1451, is being developed by TC9, Technical Committee on Sensor Technology, of the Instrumentation and Measurement Society of the Institute of Electrical and Electronic Engineers (IEEE). The proposed standard is divided into four parts. Each part is a standard, which can be standalone or can function with the other member of the P1451 family of standards. This paper briefly describes the relationship of the four standards in P1451 that deal with different aspects of transducer interfacing. These include communication protocols between transducers and microprocessors, the network-independent information model for smart transducers, the multidrop transducer bus, and the mixed-mode transducers.
A circularly polarized microstrip antenna using a crossed-slot feed (1990)

A simple configuration using a crossed-slot feed with a single microstrip line or a triplate line without a 90 degrees branch hybrid coupler to obtain the required phase shift is proposed. Measurement results on this circularly polarized microstrip antenna are presented. By using the crossed-slot feed method, a microstrip antenna with an axial ratio of less than 2 dB in a wide angle range was obtained. From these results, it was verified that circular polarization operation can be obtained by the proposed method.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Characterization of brown adipose tissue in the human perirenal depot (2014)

Our data provides the first molecular characterization of BAT in the perirenal adipose tissue depot. Furthermore, it highlights the transcription factor RXRγ as a new player in BAT development.
Enhanced power transfer and mode coupling in spun twin-core optical fibers (1996)

In a twin-core optical fiber a propagating light pulse periodically transfers power between its two cores. Experiments by Tjugiarto et al. [Opt. Lett. 17, 1058 (1992)] have demonstrated that this coupling length is considerably reduced when the fiber is also spun. A coupled-mode analysis reveals a pitch resonance that couples a cladding mode with the circularly polarized core mode whose handedness matches that of the helical twist of the cores. This resonance mechanism explains the observation of enhanced coupling and claddingmode cross coupling.
Expression of MMP-3 and TIMP-3 in gastric cancer tissue and its clinical significance (2011)

The present study aimed to investigate the expression of matrix metalloproteinase-3 (MMP-3) and the tissue inhibitor of metalloproteinase-3 (TIMP-3) in gastric cancer tissue, as well as to analyze the correlation between their expression and the occurrence of gastric cancer. Immunohistochemistry was used to determine the expression of MMP-3 and TIMP-3 in the gastric cancer tissue from 18 patients with early-stage gastric cancer (early-stage group) and 26 patients with advanced-stage gastric cancer (advanced-stage group). Transmission electron microscopy (TEM) was used to observe the lymphocytes and tumor cells in gastric cancer tissue. The results showed that the expression of TIMP-3 was significantly higher, whereas that of MMP-3 and MMP-3/TIMP-3 was lower in gastric cancer tissue of the early-stage group than in that of the advanced-stage group (P<0.05). The TEM images revealed increased lymphocytes and inconspicuous tumor cells penetrating the basement membrane in gastric cancer tissue of the early-stage group, and decreased lymphocytes and obvious tumor cells penetrating the basement membrane in the advanced-stage group. In conclusion, MMP-3 and TIMP-3 may be used as indices for the invasion and metastasis of gastric cancer and possess marked clinical significance in the prognostic judgment of gastric cancer.
Role of Indirect Laryngoscopes in Difficult Airway Management (2010)

ビデオ・光学機能を利用した喉頭鏡は近年，多種利用可能となってきた．直視型喉頭鏡である第1世代喉頭鏡の時代は，視線とチューブ通過経路が同一だったため，喉頭が見えれば挿管できたが（Can visualize, can intubate），逆に喉頭が見えなければ挿管できない（Can not visualize, can not intubate）という状況を生んだ．直視型の限界を克服するため，喉頭視認性を改善させるべく開発されたビデオ喉頭鏡のなかでも，気道解剖に合わせて極端な屈曲を有するGlideScopeなどの第2世代喉頭鏡は，喉頭視認性を改善したものの，見えても挿管できない（Can visualize, but can not intubate）という現象，およびカメラで見ていない死角での軟部組織損傷という新たな問題を生み出した．チューブ誘導機能をもつ喉頭鏡は第3世代の喉頭鏡と位置づけられ，なかでもガイド溝を有するタイプは軟部組織を鋭利なチューブ先端から保護し，かつ視線経路を再びチューブ通過経路と一致させ，第1世代のCan visualize, can intubateの原点に回帰させることを可能とした．第3世代喉頭鏡は今後の気道管理を変え，気管挿管の新たなスタンダードとなるだけの性質をもつと考えられる．
An integrated position -sensing system for a MEMS-based cochlear prosthesis. (2007)

Nearly 100,000 people worldwide have received cochlear implants to date, in which a bundle of wire electrodes (16-22) is inserted into the cochlea to electrically stimulate receptors in the auditory nerve, restoring hearing to the profoundly deaf. Replacing the traditional wire electrodes with a MEMS-based higher-density thin-film array should not only allow significantly higher frequency discrimination but could also permit monolithic integration of a real-time position-sensing system, which can not only minimize damage to any surviving hair cells during insertion, but also improve the stimulation efficiency by guiding the implant deep into the scala tympani (modiolus) and hugging the interior wall. In this dissertation, a polysilicon piezoresistive position-sensing system is integrated onto a thin-film cochlear electrode array based on bulk micromachining technology. The thin-film electrode array is supported on a substrate of boron-diffused silicon and sized for the scala tympani of the guinea pig. At the tip of the array is a wall contact sensor and along its length are eight segmented position sensors made by integrating polysilicon and its encapsulating dielectrics. Each position sensor is arranged in half Wheatstone bridge, the signal from which is time-multiplexed, amplified (gain=10 or 30) and band-limited. The effective gauge factors (EGF) of the sensors are typically about 15, permitting the tip position (implant depth) of an implanted array to be determined within 50mum while providing wall-contact output signals of more than 50mV at the tip. The silicon substrate is engineered in width and thickness to improve array flexibility and facilitate a modiolus-hugging shape while parylene-C is monolithically integrated with the array to improve its robustness. A pre-defined curvature of the array is achieved using <italic>in-situ</italic> residual stresses or post-release thermal actuation. As part of an implantable MEMS-based cochlear prosthesis, this position-sensing system uses a custom application-specific integrated circuit (ASIC) that is mounted on the rear of the array. This hybrid circuit chip interfaces with a hermetically-packaged WIMS microcontroller and wireless chip over an 8-lead polymeric cable. The 2.4mmx2.4mm ASIC operates from +/-2.5V, validates commands, generates stimulus currents, selects position sensors, compensates offsets using a 5b digital-to-analog converter, and amplifies/filters sensor outputs. As a result, array position can be reliably monitored with an adjustable refresh rate (10 times/sec) and used to improve the accuracy and depth of array placement.
Purification of Prealbumin from Human Serum (1987)

A method is presented by which prealbumin (thyroxine-binding prealbumin; tryptophan-rich prealbumin) may be purified to homogeneity from human serum. The method involves precipitation of contaminating proteins with dilute aqueous phenol, ion-exchange chromatography on DEAE-Sephacel, and gel permeation chromatography on Sephadex G-100. The yield is 25-30%, and the prealbumin is homogeneous by polyacrylamide gel electrophoresis at pH 8.9 and pH 3.6.
La formation des mots : structure et interprétation, Lexique 10, Presses universitaires de Lille, 1991, 294 p. (1992)

La formation des mots : structure et interprétation, Lexique 10, Presses universitaires de Lille, 1991, 294 p.. Un article de la revue Revue québécoise de linguistique (Morphologie) diffusée par la plateforme Érudit.
Surfactant-free emulsion electrosynthesis via power ultrasound: electrocatalytic formation of carbon–carbon bonds (2002)

Proof-of-concept of the mediated electrosynthesis of carbon–carbon bonds in totally ‘green’ surfactant-free emulsion media generated by application of power ultrasound to a biphasic water–organic mixture is illustrated by reference to three systems, some requiring further activation by light, and each catalysed by vitamin B12. The voltammetry of aqueous vitamin B12 solutions at an electrode modified with microdroplets of the organic reactant is employed to gain an insight into the electrocatalytic pathway and readily permits the identification of optimum reaction parameters, such as starting material ratios and wavelength of light. The latter are employed in proof-of-concept emulsion electrosynthesis under conditions of triple activation (electron transfer, ultrasound and light).
Advances in wearable technology and applications in physical medicine and rehabilitation (2005)

The development of miniature sensors that can be unobtrusively attached to the body or can be part of clothing items, such as sensing elements embedded in the fabric of garments, have opened countless possibilities of monitoring patients in the field over extended periods of time. This is of particular relevance to the practice of physical medicine and rehabilitation. Wearable technology addresses a major question in the management of patients undergoing rehabilitation, i.e. have clinical interventions a significant impact on the real life of patients? Wearable technology allows clinicians to gather data where it matters the most to answer this question, i.e. the home and community settings. Direct observations concerning the impact of clinical interventions on mobility, level of independence, and quality of life can be performed by means of wearable systems. Researchers have focused on three main areas of work to develop tools of clinical interest: 1)the design and implementation of sensors that are minimally obtrusive and reliably record movement or physiological signals, 2)the development of systems that unobtrusively gather data from multiple wearable sensors and deliver this information to clinicians in the way that is most appropriate for each application, and 3)the design and implementation of algorithms to extract clinically relevant information from data recorded using wearable technology. Journal of NeuroEngineering and Rehabilitation has devoted a series of articles to this topic with the objective of offering a description of the state of the art in this research field and pointing to emerging applications that are relevant to the clinical practice in physical medicine and rehabilitation.
Efficacy of Relaxin on functional recovery of post stroke patients (2014)

Relaxin showed in this analysis a positive effects on stroke patient's recovery, thus offering the broad therapeutic potential role of RLX as new drug in post-stroke patients.
Computer aided design of square spiral transformers and inductors (MIC application) (2003)

A simple, yet accurate, lumped-element model for four-port planar rectangular spiral structures has been developed. Closed-form expressions were used to generate frequency-dependent parameter values, resulting in an equivalent circuit which is easily incorporated into existing analysis packages. The method can easily be implemented in a commercial microwave computer-aided design program, allowing its use in the optimization of various types of active circuits. The technique was applied to standard and center-tapped transformer configurations, as well as to spiral inductors to 20 GHz. Comparison with measured results shows good agreement up to the first resonant frequency of the structures.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
重訪牛頓《原理》第一卷第一章有關微積分的基礎知識及第二章面積律等價於向心力的證明 (2010)

In this article , we have two main goals : The first goal is to analyze the 11 lemmas in the first chapter of the first volume in Newton's Mathematical Principles of Natural Philosophy. These lemmas are related to elementary theory of limit in calculus. We will interpret these lemmas by modern language and discuss the motive of Newton. The second goal is to trace Newton's original idea and give a rigorous proof of the equivalence of the law of centripetal force and Kepler’s area law.
Conductive materials for ESD applications: an overview (2001)

Polymer resins, because of their low cost, versatility, and ease of use, are the principal component in many static-control items. These items include containers and packages used to store and transport sensitive electronics. This paper seeks to explain how polymers are used for these demanding applications by providing a basic tutorial in polymer science as well as a brief description of the commercial polymers used in static-control products. This paper also contains a review of the various ways of imparting electrical conductivity on plastic resins through the use of antistatic agents, conductive fillers, and intrinsically conductive polymers.
Inhibition of superoxide production in human neutrophils by combinations of heparin and thrombolytic agents. (1995)

The inhibition of super oxide generation by these drug combinations may explain the limited inflammatory response and reduction of reperfusion injury observed in patients receiving thrombolytic treatment.
Toll-like Receptor–Mediated Signaling in Human Adipose-Derived Stem Cells: Implications for Immunogenicity and Immunosuppressive Potential (2008)

Human adipose-derived stem cells (hASCs) are mesenchymal stem cells with reduced immunogenicity and the capability to modulate immune responses. These properties make hASCs of special interest as therapeutic agents in the settings of chronic inflammatory and autoimmune diseases. Exogenous and endogenous toll-like receptor (TLR) ligands have been linked with the perpetuation of inflammation in a number of chronic inflammatory diseases such as inflammatory bowel disease and rheumatoid arthritis because of the permanent exposure of the immune system to TLR-specific stimuli. Therefore, hASCs employed in therapy are potentially exposed to TLR ligands, which may result in the modulation of hASC activity and therapeutic potency. In this study, we demonstrate that hASCs possess active TLR2, TLR3, and TLR4, because activation with specific ligands resulted in induction of nuclear factor kappa B-dependent genes, such as manganese superoxide dismutase and the release of interleukin (IL)-6 and IL-8. TLR3 and TLR4 ligands increased osteogenic differentiation, but no effect on adipogenic differentiation or proliferation was observed. Moreover, we show that TLR activation does not impair the immunogenic and immunosuppressive properties of hASCs. These results may have important implications with respect to the safety and efficacy of hASC-based cell therapies.
An automated temporal alignment technique for the translational and rotational correction of digital radiographic images of Bjork-Shiley heart valves (2002)

An accurate technique for the temporal registration of digital radiographic valve images is an integral process in the objective quantification of single leg separation (SLS) in Bjork-Shiley Convexo Concave heart valves. The authors have developed a fully automated technique for the translational and rotational correction of sequential valve images based on the principal axes of the valve. This technique was chosen for ease of implementation, speed, and accuracy. The first step of the alignment procedure is to correct for translational and rotational motion by aligning the centroids of segmented valve images according to their principal axes. The second step involves a rotational correction for each leg of the outlet strut using a linear cross-correlation of data sampled along a specified are about the centroid. This technique has been successfully applied to a preliminary set (10 patients) of digital radiographic data (8-16 sequential frames). This technique was determined accurate to within 2 pixels at a spatial resolution of 139 /spl mu/m/pixel.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Interaction of Sildenafil With cAMP-Mediated Vasodilation In Vivo (2002)

Sildenafil inhibits cGMP breakdown by phosphodiesterase 5. In vitro, increased cGMP levels inhibit cAMP breakdown by phosphodiesterase 3. It is uncertain, however, whether sildenafil increases biological effects of interventions increasing cAMP levels in vivo. The objective of the present study in 40 healthy male volunteers was to determine the existence and extent of interactions with sildenafil and vasodilators acting via cGMP or cAMP or independently from these mediators on the arterial tone of the human forearm. Forearm blood flow (FBF) responses (plethysmography) to brachial artery infusions of 3 doses each of nitroglycerin, which increases cGMP levels; of isoprenaline and milrinone, which increase cAMP levels; and of verapamil as a control were assessed at baseline and 80 minutes after 50 mg oral sildenafil in 10 volunteers each. Sildenafil increased FBF (2.5+/-0.1 to 3.5+/-0.2 mL/min per 100 mL, P<0.001; n=40). At equipotent vasodilator dosages, sildenafil increased FBF from 7.5+/-1.0 to 9.8+/-1.2 mL/min per 100 mL for nitroglycerin, from 8.3+/-1.0 to 10.4+/-1.4 mL/min per 100 mL for isoprenaline, and from 8.1+/-1.0 to 10.3+/-1.2 mL/min per 100 mL for milrinone and slightly decreased FBF from 7.7+/-1.3 to 7.1+/-1.2 mL/min per 100 mL for verapamil. ANOVA for repeated measures revealed a significant interaction between sildenafil and the type of vasodilator on FBF (P<0.01). The responses of FBF to nitroglycerin, milrinone, and isoprenaline after sildenafil were similarly increased compared with the response to verapamil (P<0.01). Sildenafil markedly enhanced the arterial vasodilator response to nitroglycerin, milrinone, and isoprenaline. The response to milrinone and isoprenaline is compatible with an interaction between cGMP and phosphodiesterase 3 or an enhancement of the NO component of cAMP-mediated vasodilation, and raises the possibility of enhanced biological effects of interventions leading to increases of cAMP in the presence of sildenafil.
Strontium can increase some osteoblasts without increasing hematopoietic stem cells (2007)

Osteoblasts are a key component in the regulation of the hematopoietic stem cell (HSC) niche. Manipulating osteoblast numbers results in a parallel change in HSC numbers. We tested the activity of strontium (Sr), a bone anabolic agent that enhances osteoblast function and inhibits osteoclast activity, on hematopoiesis. In vitro treatment of primary murine osteoblasts with Sr increased their ability to form bone nodules, and in vivo it increased osteoblast number, bone volume, and trabecular thickness and decreased trabecular pattern factor. However, the administration of Sr had no influence on primitive HSCs, although the number of hematopoietic progenitors was higher than in control cells. When Sr-treated mice were used as donors for HSC transplantation, no difference in the engraftment ability was observed, whereas hematopoietic recovery was delayed when they were used as recipients. Despite the changes in osteoblast numbers, no increment in the number of N-cadherin(+) osteoblasts and N-cadherin transcripts could be detected in Sr-treated mice. Therefore, increasing the overall number and function of osteoblasts without increasing N-cadherin(+) cells is not sufficient to enhance HSC quantity and function. Our study further supports the notion that N-cadherin(+) osteoblasts are fundamental in the hematopoietic niche.