gebhart/patrepeval huggingface dataset:
Flavone-rich maize: an opportunity to improve the nutritional value of an important commodity crop (2014)

Agricultural outputs have resulted in food production continuously expanding. To satisfy the needs of a fast growing human population, higher yields, more efficient food processing, and food esthetic value, new crop varieties with higher caloric intake have and continue to be developed, but which lack many phytochemicals important for plant protection and adequate human nutrition. The increasing incidence of chronic diseases such as obesity, diabetes and cardiovascular diseases, combined with social disparity worldwide prompted the interest in developing enhanced crops that can simultaneously address the two sides of the current malnutrition sword, increasing yield while providing added nutritional value. Flavones, phytochemicals associated with the beneficial effects of the Mediterranean diet, have potent anti-inflammatory and anti-carcinogenic activities. However, many Mediterranean diet-associated vegetables are inaccessible, or lowly consumed, in many parts of the world. Maize is the most widely grown cereal crop, yet most lines used for hybrid maize production lack flavones. As a first step toward a sustainable strategy to increasing the nutritional value of maize-based diets, we investigated the accumulation and chemical properties of flavones in maize seeds of defined genotypes. We show that the pericarps of the P1-rr genotype accumulate flavones at levels comparable to those present in some flavone-rich vegetables, and are mostly present in their C- and O-glycosylated forms. Some of these glycosides can be readily converted into the corresponding more active health beneficial aglycones during food processing. Our results provide evidence that nutritionally beneficial flavones could be re-introduced into elite lines to increase the dietary benefits of maize.
Adapting radar and tracking technology to an on-board automotive collision warning system (2002)

Calspan Corporation is currently developing an on-vehicle threat detection system for intersection collision avoidance (ICA) as part of its ICA program with the National Highway Traffic Safety Administration. This paper briefly reviews the system design and describes recent efforts that include the development of a multitarget tracker/Kalman filter and collision avoidance (C/A) algorithm. A current headway radar was mounted on the Calspan Instrumented Vehicle (CIV) and in traffic data were recorded. Warning functions, developed through simulation, were applied to the recorded data (non-real-time signal processing) and key Kalman filter/tracker parameters were varied. In addition, real-time performance in traffic is demonstrated. This research demonstrates the feasibility of preventing many intersection collisons.
Activation of Bacillus subtilis transcription factor sigma B by a regulatory pathway responsive to stationary-phase signals (1992)

Alternative transcription factor sigma B of Bacillus subtilis controls a stationary-phase regulon induced under growth conditions that do not favor sporulation. Little is known about the metabolic signals and protein factors regulating the activity of sigma B. The operon containing the sigma B structural gene has the gene order orfV-orfW-sigB-rsbX, and operon expression is autoregulated positively by sigma B and negatively by the rsbX product (rsbX = regulator of sigma B). To establish the roles of the orfV and orfW products, orfV and orfW null and missense mutations were constructed and tested for their effects on expression of the sigma B-dependent genes ctc and csbA. These mutations were tested in two contexts: in the first, the sigB operon was under control of its wild-type, sigma B-dependent promoter, and in the second, the sigB operon promoter was replaced by the inducible Pspac promoter. The principal findings are that (i) the orfV (now called rsbV) product is a positive regulator of sigma B-dependent gene expression; (ii) the orfW (now called rsbW) product is a negative regultor of such expression; (iii) sigma B is inactive during logarithmic growth unless the rsbW product is absent; (iv) the rsbX, rsbV, and rsbW products have a hierarchical order of action; and (v) both the rsbV and rsbW products appear to regulate sigma B activity posttranslationally. There are likely to be at least two routes by which information can enter the system to regulate sigma B: via the rsbX product, and via the rsbV and rsbW products.
A Novel Admission Control Model in Cloud Computing (2014)

With the rapid development of Cloud computing technologies and wide adopt of Cloud services and applications, QoS provisioning in Clouds becomes an important research topic. In this paper, we propose an admission control mechanism for Cloud computing. In particular we consider the high volume of simultaneous requests for Cloud services and develop admission control for aggregated traffic flows to address this challenge. By employ network calculus, we determine effective bandwidth for aggregate flow, which is used for making admission control decision. In order to improve network resource allocation while achieving Cloud service QoS, we investigate the relationship between effective bandwidth and equivalent capacity. We have also conducted extensive experiments to evaluate performance of the proposed admission control mechanism.
Smoking and pulmonary sarcoidosis: effect of cigarette smoking on prevalence, clinical manifestations, alveolitis, and evolution of the disease. (1988)

Patients with pulmonary sarcoidosis are less likely to smoke than persons of a similar age in the general population. This could be because smoking reduces the likelihood of developing sarcoidosis, or alternatively smoking could reduce the severity of the disease process so that smoking patients are underrepresented among patients with clinically overt disease. To evaluate these possibilities 64 patients with sarcoidosis of recent onset were studied at presentation and after a one year follow up period, clinical, functional, radiographic, and bronchoalveolar lavage fluid criteria being used to identify factors that might account for the lower incidence of sarcoidosis in smokers and to determine whether the disease is less severe in smoking patients. Smoking was less common in the patients with sarcoidosis (30%) than in the control subjects (46%). The study did not support the conclusion that sarcoidosis is less severe in smokers, as clinical, radiographic, and functional abnormalities were similar in smokers and non-smokers at initial evaluation and after a one year follow up period. Nevertheless, smoking did influence various indices used to assess disease "activity." Cigarette smoking was associated with a significant increase in the serum angiotensin converting enzyme activity (SACE), and patients with very high SACE and pulmonary gallium-67 uptake were smokers. Furthermore, more CD8+ (but not CD4+) lymphocytes were recovered by lavage from smoking than from non-smoking patients, giving a lower CD4: CD8 ratio in smokers. Fewer alveolar macrophages were recovered by lavage from smokers with sarcoidosis than from normal subjects with a similar smoking history. These finding support the possibility that smokers, particularly those with a prominent accumulation of alveolar macrophages in the lower respiratory tract, may be less likely to develop sarcoidosis.
Photoreleasable thiol chemistry for facile and efficient bioconjugation (2013)

A facile methodology for light-triggered release of thiols under mild conditions is presented, which can be utilized for in situ bioconjugation with protein and quantum dot nanoparticles (QDs) efficiently.
A mulher âncora no SBT Brasil (2017)

Este artigo objetiva organizar, coletar, aferir e interpretar as informações e resultados obtidos por meio de análise de conteúdo. Na metodologia, utilizamos também critérios de noticiabilidade. Com os métodos utilizados, o estudo trouxe à luz características do âncora e a real participação da mulher âncora no telejornal noturno SBT Brasil. Dessa forma, o trabalho comprovou que o SBT, além de ter utilizado o telejornalismo norte-americano como parâmetro, fornece a liberdade editorial às mulheres âncoras na bancada do SBT Brasil. Em alguns casos, a mulher âncora atingiu uma maior participação do que o homem âncora. Situação diferente da vivenciada pela norte-americana Barbara Walters, a primeira mulher âncora do telejornalismo, que chegou a esse posto apenas em 1976 na rede ABC. O estudo ainda buscou enriquecer a escassa bibliografia a respeito do tema, além de defender a maior participação da mulher jornalista brasileira.
Erythritol as sweetener—wherefrom and whereto? (2017)

Erythritol is a naturally abundant sweetener gaining more and more importance especially within the food industry. It is widely used as sweetener in calorie-reduced food, candies, or bakery products. In research focusing on sugar alternatives, erythritol is a key issue due to its, compared to other polyols, challenging production. It cannot be chemically synthesized in a commercially worthwhile way resulting in a switch to biotechnological production. In this area, research efforts have been made to improve concentration, productivity, and yield. This mini review will give an overview on the attempts to improve erythritol production as well as their development over time.
Symbian OS Architecture : 携帯電話OSの設計と進化 (2008)

第１部 Ｓｙｍｂｉａｎ ＯＳの背景情報（なぜ「電話機は違う」のか；Ｓｙｍｂｉａｎ ＯＳの歴史と前史 ほか） 第２部 レイヤで見るアーキテクチャ（Ｓｙｍｂｉａｎ ＯＳのレイヤードモデル；ＵＩ Ｆｒａｍｅｗｏｒｋレイヤ ほか） 第３部 設計のケーススタディ（Ｓｙｍｂｉａｎ ＯＳにおけるオブジェクト指向設計の利用；電話を加えるだけで ほか） 付録（Ｓｙｍｂｉａｎ ＯＳコンポネントリファレンス；インタビューを受けた人々の紹介）
Depletion of Virion-Associated Divalent Cations Induces Parvovirus Minute Virus of Mice To Eject Its Genome in a 3′-to-5′ Direction from an Otherwise Intact Viral Particle (2009)

We describe a structural rearrangement that can occur in parvovirus minute virus of mice (MVMp) virions following prolonged exposure to buffers containing 0.5 mM EDTA. Such particles remain stable at 4 degrees C but undergo a conformational shift upon heating to 37 degrees C at pH 7.2 that leads to the ejection of much of the viral genome in a 3'-to-5' direction, leaving the DNA tightly associated with the otherwise intact capsid. This rearrangement can be prevented by the addition of 1 mM CaCl(2) or MgCl(2) prior to incubation at 37 degrees C, suggesting that readily accessible divalent cation binding sites in the particle are critical for genome retention. Uncoating was not seen following the incubation of virions at pH 5.5 and 37 degrees C or at pH 7.2 and 37 degrees C in particles with subgenomic DNA, suggesting that pressure exerted by the full-length genome may influence this process. Uncoated genomes support complementary-strand synthesis by T7 DNA polymerase, but synthesis aborts upstream of the right-hand end, which remains capsid associated. We conclude that viral genomes are positioned so that their 3' termini and coding sequences can be released from intact particles at physiological temperatures by a limited conformational rearrangement. In the presence of divalent cations, incremental heating between 45 degrees C and 65 degrees C induces structural transitions that first lead to the extrusion of VP1 N termini, followed by genome exposure. However, in cation-depleted virions, the sequence of these shifts is blurred. Moreover, cation-depleted particles that have been induced to eject their genomes at 37 degrees C continue to sequester their VP1 N termini within the intact capsid, suggesting that these two extrusion events represent separable processes.
A Novel Purification Method of Murine Embryonic Stem Cell– and Human-Induced Pluripotent Stem Cell–Derived Cardiomyocytes by Simple Manual Dissociation (2012)

Cardiomyocytes derived from embryonic stem cells (ES-CMs) and induced pluripotent stem cells (iPS-CMs) are useful for toxicity and pharmacology screening. In the present study, we found that cardiomyocyte-rich beating cell clusters (CCs) emerged from murine embryonic stem cell (mESC)-derived beating EBs and from human-induced pluripotent stem cell (hiPSC)-derived beating EBs dissociated by gentle pipetting with a thin glass pipette. The percentage of cardiac troponin T (cTnT)-positive cells in the beating CCs obtained from mESC-derived and hiPSC-derived beating EBs was higher (81.5% and 91.6%, respectively) than in beating-undissociated EBs (13.7% and 67.1%, respectively). For mESCs, the yield of cTnT-positive cells from beating CCs was estimated to be 1.6 times higher than that of beating EBs. The bromodeoxyuridine labeling index of mouse ES-CMs and human iPS-CMs in beating CCs was 1.5- and 3.2-fold, respectively, greater than those in beating EBs. To investigate the utility of the cells in toxicity assessment, we showed that doxorubicin, a cardiotoxic drug, induced myofilament disruption in cardiomyocytes isolated by this method. This simple method enables preparation of mouse ES-CMs and human iPS-CMs with better proliferative activity than beating EBs not dissociated by pipetting, and the cardiomyocytes are useful for drug-induced myocardial toxicity testing.
Fuzzy Allocation of Fine-Grained Compute Resources for Grid Data Streaming Applications (2011)

Fine-grained allocation of compute resources, in terms of configurable clock speed of virtual machines, is essential for processing efficiency and resource utilization of data streaming applications. For a data streaming application, its processing speed is expected to approach the allocated bandwidth as much as possible. Automatic control technology is a feasible solution, but the plant model is hard to be derived. In relation to the model free characteristic, a fuzzy logic controller is designed with several simple yet robust rules. Performance of this controller is verified to out-perform classic controllers in response rapidness and less oscillation. An empirical formula on tuning an essential parameter is obtained to achieve better performance.
The Pineal Gland and Spontaneous Abortions: Implications for Therapy with Melatonin and Magnetic Field (1991)

Spontaneous abortion, the termination of pregnancy prior to 20 weeks of gestation, is estimated to occur in 40%-50% of all pregnancies and in 12%-15% of identified pregnancies. The causes of spontaneous abortion can be divided into two main categories: those arising from chromosomal anomalies and those arising from abnormalities in the intrauterine environment. In the following communication, we propose that deficient pineal melatonin functions in early pregnancy may be causally related to the development of spontaneous abortions in cases where chromosomal anomalies or structural abnormalities of the uterus have been excluded. This hypothesis is based on the findings that: (a) melatonin plasma levels normally increase by 200%-300% in the first 20 weeks of pregnancy; (b) melatonin decreases uterine contractility in the rat; (c) melatonin stimulates the secretion of progesterone, which decreases uterine contractility and prevents immunological rejection of the trophoblast; (d) melatonin inhibits the synthesis of prostaglandins, which are potent inducers of uterine contractility and labor, and (e) pinealectomy increases the number of spontaneous abortions in pregnant rats. In addition, since melatonin is a hormone with immunosuppressant properties, we propose that the increased melatonin production in early pregnancy may contribute to a state of "transplantation immunity" to the paternal histocompatibility antigens preventing immunological rejection of the trophoblast. If this hypothesis is correct, then plasma melatonin, levels during early pregnancy could be used as an indicator for increased risk of spontaneous abortions.(ABSTRACT TRUNCATED AT 250 WORDS)
Genetic Determinants of Spindle Pole Body Duplication in Budding Yeast (1991)

A key function in the eukaryotic cell cycle is the formation of the bipolar mitotic spindle. This complex process depends in turn on duplication of the centrosome, which arises from the single spindle pole inherited by each daughter cell from the preceding mitotic division. The nature of this duplication and its mode of regulation remain somewhat obscure, for the centrosome usually is identifiable only as a poorly defined array of amorphous material from which the majority of microtubules appear to emanate. In animal cells, the centrioles that lie within the core of the centrosome provide a distinctive marker for centrosomal distribution (Mclntosh 1983), but the precise behavior of the diffusely arrayed centrosomal material that surrounds them is difficult to specify. In contrast, the analogous material in yeast and other fungi appears as a discrete organelle--the spindle pole body (SPB)--whose pattern of duplication can be recognized more readily (Byers and Goetsch 1975)...
Decentralized Neighborhood Energy Management With Coordinated Smart Home Energy Sharing (2017)

This paper introduces a day-ahead energy management algorithm for the coordination of smart homes with renewable energy sources and energy storage systems in neighborhood areas. The aim of this paper is to establish a day-ahead decentralized coordination method with appliance scheduling and energy sharing (among smart homes) to minimize the electricity bills of consumers under dynamic pricing. The energy sharing algorithm focuses on increasing the utilization of renewable sources by controlling storage units. A multi-agent system is used to model entities (smart homes, aggregator, and utility) as agents and the optimization problem is solved in a decentralized manner by home agents with a genetic algorithm. The performance of the coordination algorithm is evaluated annually with and without considering forecasting errors.
Syntheses and Cytotoxic Properties of the Curcumin Analogs 2,6‐Bis(benzylidene)‐4‐phenylcyclohexanones (2008)

Fifteen curcumin analogs were synthesized and tested for in-vitro cytotoxicity towards B16 and L1210 murine cancer cell lines using an MTT assay. Significant activity was discovered for two analogs: 8 (B16 IC(50) = 1.6 microM; L1210 IC(50) = 0.35 microM) and 9 (B16 IC(50) = 0.51 microM; L1210 IC(50 )= 1.2 microM). Several other analogs exhibited notable cytotoxicity. The data from quantitative structure-activity relationships suggest that large electron-withdrawing substituents placed in the meta-position of the arylidene aryl rings enhance potencies. Compounds 8 and 9 were found using a cell-based assay to have virtually no effects on microtubules at concentrations up to 40 microM. These results suggest that tubulin inhibition is not the principal mechanism by which the curcumin analogs act.
An edge-oriented progressive image coding (1996)

An edge-oriented progressive image coding scheme using a hierarchical edge extraction is presented. This scheme is based on the two-component model, that is, edges and smooth component. We introduce searching near an approximate location algorithm for the edge extraction to avoid detecting spurious edges, thus, one can reproduce a primary image which conveys a general grasp of the scene while achieving the compression ratios as high as 250:1 for a head-and-shoulder image. By adding the smooth component to the primary image, we obtain acceptable quality images at the compression ratios over 60:1. It is shown through the simulations that the proposed scheme results in performance improvements over MPEG-2 I-picture coding in terms of both the subjective quality and signal-to-noise ratio. The main contributors of the performance improvement are: (1) a compact representation of the edge information using a hierarchical edge extraction and (2) a residual coding with a variable block size discrete cosine transform (DCT) employing an edge-based block segmentation.
Comparison of the mismatch-specific endonuclease method and denaturing high-performance liquid chromatography for the identification of HBB gene mutations (2008)

Compared to the DHPLC approach, the mismatch-specific endonuclease method allows mutational screening of a large number of samples because of its speed, sensitivity and adaptability to semi-automated systems. These findings demonstrate the feasibility of using the mismatch-specific endonuclease method as a tool for mutation screening.
A dose‐ranging study of the efficacy and safety of tamsulosin, the first prostate‐selective &agr; <sub>1A</sub> ‐adrenoceptor antagonist*, in patients with benign prostatic obstruction (1997)

Tamsulosin is well tolerated and effective in improving urinary flow and relieving LUTS associated with BPO. Optimal effects are achieved with tamsulosin 0.4 mg administered once daily.
Blocking Metabotropic Glutamate Receptor Subtype 7 (mGlu7) via the Venus Flytrap Domain (VFTD) Inhibits Amygdala Plasticity, Stress, and Anxiety-related Behavior (2014)

The metabotropic glutamate receptor subtype 7 (mGlu7) is an important presynaptic regulator of neurotransmission in the mammalian CNS. mGlu7 function has been linked to autism, drug abuse, anxiety, and depression. Despite this, it has been difficult to develop specific blockers of native mGlu7 signaling in relevant brain areas such as amygdala and limbic cortex. Here, we present the mGlu7-selective antagonist 7-hydroxy-3-(4-iodophenoxy)-4H-chromen-4-one (XAP044), which inhibits lateral amygdala long term potentiation (LTP) in brain slices from wild type mice with a half-maximal blockade at 88 nm. There was no effect of XAP044 on LTP of mGlu7-deficient mice, indicating that this pharmacological effect is mGlu7-dependent. Unexpectedly and in contrast to all previous mGlu7-selective drugs, XAP044 does not act via the seven-transmembrane region but rather via a binding pocket localized in mGlu7's extracellular Venus flytrap domain, a region generally known for orthosteric agonist binding. This was shown by chimeric receptor studies in recombinant cell line assays. XAP044 demonstrates good brain exposure and wide spectrum anti-stress and antidepressant- and anxiolytic-like efficacy in rodent behavioral paradigms. XAP044 reduces freezing during acquisition of Pavlovian fear and reduces innate anxiety, which is consistent with the phenotypes of mGlu7-deficient mice, the results of mGlu7 siRNA knockdown studies, and the inhibition of amygdala LTP by XAP044. Thus, we present an mGlu7 antagonist with a novel molecular mode of pharmacological action, providing significant application potential in psychiatry. Modeling the selective interaction between XAP044 and mGlu7's Venus flytrap domain, whose three-dimensional structure is already known, will facilitate future drug development supported by computer-assisted drug design.
Mutual exclusion of roles as a means of implementing separation of duty in role-based access control systems (1997)

Article Mutual exclusion of roles as a means of implementing separation of duty in role-based access control systems Share on Author: D. Richard Kuhn National Institute of Standards and Technology, Gaithersburg, Maryland National Institute of Standards and Technology, Gaithersburg, MarylandView Profile Authors Info & Claims RBAC '97: Proceedings of the second ACM workshop on Role-based access controlNovember 1997 Pages 23–30https://doi.org/10.1145/266741.266749Online:06 November 1997Publication History 86citation858DownloadsMetricsTotal Citations86Total Downloads858Last 12 Months16Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access