gebhart/patrepeval huggingface dataset:
Flexible online task assignment in real-time spatial data (2017)

The popularity of Online To Offline (O2O) service platforms has spurred the need for online task assignment in real-time spatial data, where streams of spatially distributed tasks and workers are matched in real time such that the total number of assigned pairs is maximized. Existing online task assignment models assume that each worker is either assigned a task immediately or waits for a subsequent task at a fixed location once she/he appears on the platform. Yet in practice a worker may actively move around rather than passively wait in place if no task is assigned. In this paper, we define a new problem <u>F</u>lexible <u>T</u>wo-sided <u>O</u>nline task <u>A</u>ssignment (FTOA). FTOA aims to guide idle workers based on the prediction of tasks and workers so as to increase the total number of assigned worker-task pairs. To address the FTOA problem, we face two challenges: (i) How to generate guidance for idle workers based on the prediction of the spatiotemporal distribution of tasks and workers? (ii) How to leverage the guidance of workers' movements to optimize the online task assignment? To this end, we propose a novel two-step framework, which integrates offline prediction and online task assignment. Specifically, we estimate the distributions of tasks and workers per time slot and per unit area, and design an online task assignment algorithm, <u>P</u>rediction-oriented <u>O</u>nline task <u>A</u>ssignment in <u>R</u>eal-time spatial data (POLAR-OP). It yields a 0.47-competitive ratio, which is nearly twice better than that of the state-of-the-art. POLAR-OP also reduces the time complexity to process each newly-arrived task/worker to O(1). We validate the effectiveness and efficiency of our methods via extensive experiments on both synthetic datasets and real-world datasets from a large-scale taxi-calling platform.
Competitiveness and processes: integrating engineering in thecapital goods industry (1995)

Discusses the way in which effective management of business processes can deliver improved competitiveness‐via specific reference to engineering in the capital goods (CG) industry. Having defined the critical success factors which differentiate the CG sector, shows how the resulting organizational dynamic is best served by an entirely new multi‐disciplinary approach. This delivers the required outcome by collapsing both lead and response times and facilitating the construction of a fully‐integrated operational and knowledge base.
THE CYCLOÖCTATETRAENYL DIANION (1960)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTHE CYCLOÖCTATETRAENYL DIANIONThomas J. KatzCite this: J. Am. Chem. Soc. 1960, 82, 14, 3784–3785Publication Date (Print):July 1, 1960Publication History Published online1 May 2002Published inissue 1 July 1960https://pubs.acs.org/doi/10.1021/ja01499a077https://doi.org/10.1021/ja01499a077research-articleACS PublicationsRequest reuse permissionsArticle Views1289Altmetric-Citations198LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
An atypical <scp>CD</scp>8 T‐cell response to <i>Chlamydia muridarum</i> genital tract infections includes T cells that produce interleukin‐13 (2014)

Chlamydia trachomatis urogenital serovars D-K are intracellular bacterial pathogens that replicate almost exclusively in human reproductive tract epithelium. In the C. muridarum mouse model for human Chlamydia genital tract infections CD4 T helper type 1 cell responses mediate protective immunity while CD8 T-cell responses have been associated with scarring and infertility. Scarring mediated by CD8 T cells requires production of tumour necrosis factor-α (TNF-α); however, TNF-α is associated with protective immunity mediated by CD4 T cells. The latter result suggests that TNF-α in-and-of itself may not be the sole determining factor in immunopathology. CD8 T cells mediating immunopathology presumably do something in addition to producing TNF-α that is detrimental during resolution of genital tract infections. To investigate the mechanism underlying CD8 immunopathology we attempted to isolate Chlamydia-specific CD8 T-cell clones from mice that self-cleared genital tract infections. They could not be derived with antigen-pulsed irradiated naive splenocytes; instead derivation required use of irradiated immune splenocyte antigen-presenting cells. The Chlamydia-specific CD8 T-cell clones had relatively low cell surface CD8 levels and the majority were not restricted by MHC class Ia molecules. They did not express Plac8, and had varying abilities to terminate Chlamydia replication in epithelial cells. Two of the five CD8 clones produced interleukin-13 (IL-13) in addition to IL-2, TNF-α, IL-10 and interferon-γ. IL-13-producing Chlamydia-specific CD8 T cells may contribute to immunopathology during C. muridarum genital tract infections based on known roles of TNF-α and IL-13 in scar formation.
Bit error rate measurement of free space optical communication links under laboratory-controlled fog conditions (2011)

This paper outlines the experimental investigation of the fog effect on the bit error rate (BER) performance of the free space optical (FSO) communication link under a controlled laboratory environment. The link transmittance and the received signal Q-factor are measured against different levels of fog densities. The link visibility derived from fog attenuation measurement is used to characterize the fog within the chamber. Moreover, the effect of using different average transmitted optical communication power (Popt) on the transmittance and received Q-factor of the link is also studied for light and dense fog densities.
Sonocatalytic facilitation of hydroxyl radical generation in the presence of TiO2 (2008)

The generation of hydroxyl (OH) radicals was investigated during ultrasonic irradiation and in the presence of TiO(2). The effect of TiO(2) on an ultrasonic system's oxidation power was evaluated by examining the oxidation of salicylic acid. The generation of the salicylic acid derivatives, 2,3-dihydroxybenzoic acid (DHBA) and 2,5-DHBA, was measured by high-performance liquid chromatography coupled with electrochemical detection under different experimental conditions. The presence of TiO(2) enhanced the generation of DHBA during ultrasonic irradiation, thus indicating a higher oxidation power in the ultrasonic system. Al(2)O(3) also increased the generation of DHBA during irradiation; however, the effect of TiO(2) was found to be higher than that of Al(2)O(3). The addition of OH radical scavengers such as dimethylsulfoxide (DMSO), methanol and mannitol significantly suppressed the production of DHBA, and DMSO was found to have the highest suppressive effect among all scavengers. The effects of dissolved gases on the generation of OH radicals were further studied, and their power was found to be in the order Xe > Ar > O(2) > N(2). The degassing of the irradiation solution completely suppressed the generation of OH radicals. These results indicate that the presence of TiO(2) accelerates the generation of OH radicals during ultrasonic irradiation, and that the process may be mediated through the induction of cavitation bubbles in irradiating solutions.
Targeting the Toll of Drug Abuse: The Translational Potential of Toll-Like Receptor 4 (2015)

There is growing recognition that glial proinflammatory activation importantly contributes to the rewarding and reinforcing effects of a variety of drugs of abuse, including cocaine, methamphetamine, opioids, and alcohol. It has recently been proposed that glia are recognizing, and becoming activated by, such drugs as a CNS immunological response to these agents being xenobiotics; that is, substances foreign to the brain. Activation of glia, primarily microglia, by various drugs of abuse occurs via toll like receptor 4 (TLR4). The detection of such xenobiotics by TLR4 results in the release of glial neuroexcitatory and neurotoxic substances. These glial products of TLR4 activation enhance neuronal excitability within brain reward circuitry, thereby enhancing their rewarding and reinforcing effects. Indeed, selective pharmacological blockade of TLR4 activation, such as with the non-opioid TLR4 antagonist (+)-naltrexone, suppresses a number of indices of drug reward/reinforcement. These include: conditioned place preference, self-administration, drugprimed reinstatement, incubation of craving, and elevations of nucleus accumbens shell dopamine. Notably, TLR4 blockade fails to alter self-administration of food, indicative of a selective effect on drugs of abuse. Genetic disruption of TLR4 signaling recapitulates the effects of pharmacological TLR4 blockade, providing converging lines of evidence of a central importance of TLR4. Taken together, multiple lines of evidence converge to raise TLR4 as a promising therapeutic target for drug abuse.
A Note on Autocorrelation Analysis of Speech Sounds (1954)

By separating a speech wave into its temporal and structural factors, it is possible to reveal concisely and explicitly how the vocal cavity characteristics and the periodicity of the laryngeal excitation enter into the autocorrelation function of the speech wave. This representation provides a simple explanation for the differences between the conventional spectrogram and the correlatogram, such as the marked sensitivity of the latter to variations in pitch and other nonphonemic qualities of the voice, which have been described in a recent paper by Biddulph. A scheme for using cross correlation to avoid the quadratic suppression of weaker components in the autocorrelation function is suggested.
Age and scholarly impact. (1989)

The claim that older scientists generate research of lower quality than do younger scientists was tested through two analyses in which the age distribution of authors of frequently cited articles in psychology journals was compared with the age distribution of authors of low-impact articles published in the same journals. Most high-impact articles were published by relatively young psychologists, but so were most low-impact articles. When allowance was made for relative numerical representation, there was no evidence that publications from older scientists have less impact. Results are discussed in the context of methodological issues in evaluation of relations between age and scientific achievement.
Femtosecond pulse generation with voltage-controlled graphene saturable absorber (2014)

We report, for the first time to our knowledge, the demonstration of a graphene supercapacitor as a voltage-controlled saturable absorber for femtosecond pulse generation from a solid-state laser. By applying only a few volts of bias, the Fermi level of the device could be shifted to vary the insertion loss, while maintaining a sufficient level of saturable absorption to initiate mode-locked operation. The graphene supercapacitor was operated at bias voltages of 0.5-1V to generate sub-100 fs pulses at a pulse repetition rate of 4.51 MHz from a multipass-cavity Cr(4+):forsterite laser operating at 1255 nm. The nonlinear optical response of the graphene supercapacitor was further investigated by using pump-probe spectroscopy.
Polymorphism and domain variability of human killer cell inhibitory receptors (1997)

Thirty-two different full-length cDNA clones for human killer cell inhibitory receptors (KIR) have been identified. They all belong to the immunoglobulin superfamily and encode mature proteins with one, two or three extracellular Ig domains. The inhibitory receptors have nearly identical transmembrane domains and cytoplasmic domains ranging in length from 76 to 95 amino-acid residues. The activating receptors have a characteristic transmembrane domain with a charged lysine residue and a short cytoplasmic tail without the protein tyrosine phosphatase binding motif I/VXYXXL present in the inhibitory receptors. Sequence analysis demonstrates that three clusters correspond to the inhibitory receptors of 58 kDa, while two clusters encode activating receptors of 50 kDa. Two other clusters correspond to the inhibitory receptors of 70 kDa and one cluster encodes genes with sequence homology to one of the two p70 clusters but contains the transmembrane and cytoplasmic domains characteristic of activating receptors. The data are consistent with a genomic organization of the KIR genetic region containing at least three KIR genes encoding receptors for each of the gene products of the HLA class I loci. Alternative mRNA splicing could be responsible for generation of activating or inhibitory receptors with the same extracellular domains. Separate genes encoding receptors with opposite function is, however, an equally likely possibility.
From Accumulation to Degradation: Reprogramming Polyamine Metabolism Facilitates Dark-Induced Senescence in Barley Leaf Cells (2016)

The aim of this study was to analyze whether polyamine (PA) metabolism is involved in dark-induced Hordeum vulgare L. 'Nagrad' leaf senescence. In the cell, the titer of PAs is relatively constant and is carefully controlled. Senescence-dependent increases in the titer of the free PAs putrescine, spermidine, and spermine occurred when the process was induced, accompanied by the formation of putrescine conjugates. The addition of the anti-senescing agent cytokinin, which delays senescence, to dark-incubated leaves slowed the senescence-dependent PA accumulation. A feature of the senescence process was initial accumulation of PAs at the beginning of the process and their subsequent decrease during the later stages. Indeed, the process was accompanied by both enhanced expression of PA biosynthesis and catabolism genes and an increase in the activity of enzymes involved in the two metabolic pathways. To confirm whether the capacity of the plant to control senescence might be linked to PA, chlorophyll fluorescence parameters, and leaf nitrogen status in senescing barley leaves were measured after PA catabolism inhibition and exogenously applied γ-aminobutyric acid (GABA). The results obtained by blocking putrescine oxidation showed that the senescence process was accelerated. However, when the inhibitor was applied together with GABA, senescence continued without disruption. On the other hand, inhibition of spermidine and spermine oxidation delayed the process. It could be concluded that in dark-induced leaf senescence, the initial accumulation of PAs leads to facilitating their catabolism. Putrescine supports senescence through GABA production and spermidine/spermine supports senescence-dependent degradation processes, is verified by H2O2 generation.
Stable immobilization of rat hepatocytes as hemispheroids onto collagen‐conjugated poly‐dimethylsiloxane (PDMS) surfaces: Importance of direct oxygenation through PDMS for both formation and function (2007)

The highly oxygen-permeable material, poly-dimethylsiloxane (PDMS), has the potential to be applied to cell culture microdevices, but cell detachment from PDMS has been a major problem. In this study, we demonstrate that a combination of collagen covalently immobilized PDMS and an adequate oxygen supply enables the establishment of a stable, attached spheroid (hemispheroid) culture of rat hepatocytes. The bottom PDMS surfaces were first treated with oxygen plasma, then coupled with aminosilane followed by a photoreactive crosslinker, and they were finally reacted with a collagen solution. X-ray photoelectron spectroscopy (XPS) and contact angle measurements showed that the covalent immobilization of collagen on the surface occurred only where the crosslinker had been introduced. On the collagen-conjugated PDMS surface, rat hepatocytes organized themselves into hemispheroids and maintained the viability and a remarkably high albumin production at least for 2 weeks of culture. In contrast, hepatocytes on the other types of PDMS surfaces formed suspended spheroids that had low albumin production. In addition, we showed that blocking the oxygen supply through the bottom PDMS surface inhibited the formation of hemispheroids and the augmentation of hepatocellular function. These results show that appropriate surface modification of PDMS is a promising approach towards the development of liver tissue microdevices.
Stimulation of 5-lipoxygenase activity under conditions which promote lipid peroxidation (1989)

The characteristics of hydroperoxide activation of 5-lipoxygenase were examined in the high speed supernatant fraction prepared from rat polymorphonuclear leukocytes. Stimulation of 5-lipoxygenase activity by the 5-hydroperoxyeicosatetraenoic acid (5-HPETE) reaction product was strongly dependent on the presence of thiol compounds. Various reducing agents such as mercaptoethanol and glutathione (0.5-2 mM) inhibited the reaction and increased the concentrations of 5-HPETE (1-10 microM) necessary to achieve maximal arachidonic acid oxidation. The requirement for 5-HPETE was not specific and could be replaced by H2O2 (10 microM) but not by the 5-hydroxyeicosatetraenoic acid (5-HETE) analogue. Furthermore, gel filtration chromatography of the soluble extract from leukocytes resolved different fractions which can increase the hydroperoxide dependence or fully replace the stimulation by 5-HPETE. Maximal activity of the 5-HPETE-stimulated reaction required Ca2+ ions (0.2-1 mM) and ATP with the elimination of the HPETE requirement at high ATP concentrations (2-4 mM). In addition, NADPH (1-2 mM), FAD (1 mM), Fe2+ ions (20-100 microM) and chelated Fe3+ (0.1 mM-EDTA/0.1 mM-FeCl3) all markedly increased product formation by 5-lipoxygenase whereas NADH (1 mM) was inhibitory and Fe3+ (20-100 microM) alone had no effect on the reaction. The stimulation by Fe2+ ions and NADPH was also observed under various conditions which increase the hydroperoxide dependence such as pretreatment of the enzyme preparation with glutathione peroxidase or chemical reduction with 0.015% NaBH4. These results provide evidence for an hydroperoxide activation of 5-lipoxygenase which is not product-specific and is modulated by thiol levels and several soluble components of the leukocytes. They also indicate that stimulation of 5-lipoxygenase activity can contribute to increase lipid peroxidation in iron and nucleotide-promoted reactions.
Microprocessors and integrated electronic technology (1976)

The microprocessor has made it possible for a standard complex function to be employed in a broad range of applications that extends the applicability of large-scale integration (LSI) to many situations that could not support special chip designs. This in turn has freed the technology from previous restrictions to evolve in directions appropriate for microprocessors and associated LSI functions. The result is that many new variations of cirucit design and process technology have arisen that lead toward more dense and higher performance integrated-circuit structures.
Animation framework for MPEG-4 systems (2002)

In this paper, we propose a new animation framework based on MPEG-4 and VRML file format. Both standards provide means to represent and compress the 3D contents. In this proposal, a framework of animation consists of behaviors to make up an animation scene. Rich animation through VRML and MPEG-4 will be possible through the introduction of new static tools. A new structure for animation with the new static tools is detailed in the paper. For instance, animation tracks are proposed to contain the description of behaviors with PROTOs. The proposed framework is dedicated for animation applications where interactivity is suited better than conventional broadcast scenario.
Customer optimization route and evaluation (CORE) for product design (2001)

To date many general procedural models to formulate the design process and to assess the quality of design have been described by industrialists and researchers. Despite similarities, all suggested methodologies contain various types of information that provide few possibilities for practitioners to consider users' reactions towards product attributes. Therefore, in practice and in a majority of cases, designers and manufacturers, while deploying huge investments in research and development in product design, are still bemused by the complexity of preferences by customers. The model presented in this paper, Customer Optimization Route and Evaluation (CORE), addresses the need for interactions between design and market needs. A method to translate customers' qualitative requirements into design technical attributes is introduced in CORE. Cutomer's satisfaction level for each product attribute is then evaluated, offering guidelines to designers for improvement in product design. This model is applied to a real example in the service industry offering Intranet services. Results of the study are analysed and proposals are given to improve the present product.
Water drinking in the management of orthostatic intolerance due to orthostatic hypotension, vasovagal syncope and the postural tachycardia syndrome (2004)

Water drinking recently has been shown to raise blood pressure in normal subjects and in patients with autonomic failure who have orthostatic hypotension. However, in normal young subjects, ingestion of approximately 500 ml has no pressor effect; but in older subjects there is an increase in blood pressure. An even greater rise in blood pressure occurs in cases with autonomic failure. The possible mechanisms responsible for the pressor response to water include neural and humoral factors; fluid redistribution also needs to be considered. This review will concentrate on the water pressor response in normal subjects and different groups of patients with autonomic diseases who have orthostatic intolerance, on the mechanisms that could be involved, and on whether this pressor response may be used in the management of orthostatic hypotension, vasovagal syncope and the postural tachycardia syndrome.
Beyond Aliasing Regularisation by Plane Event Extraction (2007)

P144 Beyond Aliasing Regularisation by Plane Event Extraction P. Hugonnet* (CGGVeritas) & J.L. Boelle (Total E&P) SUMMARY The regularisation problem (i.e. moving the seismic traces onto a regular spatial grid) has often to deal with spatial aliasing since the 3D seismic data are always under-sampled along one or several spatial directions and de-aliasing them prior to regularisation is not always possible. “Beyond aliasing” regularisation algorithms are then required. We present herein such an algorithm working in 3D (t-x-y) and based on the accurate extraction of local plane events through an inversion process. Beyond-aliasing algorithms tend however to smooth the data