gebhart/patrepeval huggingface dataset:
A variant 2677A allele of the gene affects fexofenadine disposition (2004)

The plasma concentrations of fexofenadine after a single oral administration were lower in 2677AA/3435CC subjects than in subjects with the other 5 genotype combinations of the SNPs of G2677T/A and C3435T. These findings confirm the importance of analyzing MDR1 haplotypes and provide a plausible explanation for the conflicting results regarding the effect of MDR1 polymorphisms on the disposition of P-gp substrates.
Electric Power Conservation Technology for Wireless Sensor Networks (2009)

Wireless networks comprised of sensors with wireless communication functions are called wireless sensor networks. Diverse research and development is being carried out for these networks, with applications anticipated for environmental monitoring, automated metering, structure monitoring and home security. Wireless sensor networks add wireless communication functions to sensors, comprise wireless multi-hop networks to broaden the scope of observations and make the installation process of the sensors easier. The requirements for such wireless sensor networks include battery driven operations and sensing periods that last over a long term, often lasting several years. Currently available wireless sensor network technologies, however, are restricted by the fact that the relaying sensor nodes are unable to be operated in an energy saving mode, thus it is difficult to operate battery driven sensor nodes over many years. Such restrictions narrow down the scope of application for wireless sensor networks creating a need for the development of a technology that enables all sensor nodes in a network to perform in an energy saving mode. People are becoming more and more aware of issues relating to the global environment and in such circumstances it is often said that it is important to understand the current status of the global environment. Wireless sensor networks have been considered for implementation as a means to understanding the current status. When environmental monitoring systems or energy conservation systems are being established using wireless sensor networks, the implementation of such systems may bring about an extremely high electric power conservation effect, but if electric power conservation of the system itself is not adequate or if wiring for the power source to the feed sensor nodes is necessary in order to install such electric power conservation systems, the value of such electric power conservation systems may be diminished. The electric power conserving technology for sensor nodes, developed through our research, converts nodes into electric power conserving types, conserving energy of the system itself and conserving electric power consumed by nodes, which made the wiring of the power supply to these nodes unnecessary, thereby improving the ease of installation. Therefore, this is expected to promote the popularization of systems for conserving energy using wireless sensor networks.
Rate adaptive OFDM (RA-OFDM) spread spectrum system for LEO satellite communications (2003)

Wireless communications systems in a tactical environment must be able to function effectively in a channel characterized by multipath fading and interference. Additionally, current and future communications requirements will necessitate the transmission of many different types of information with a wide range of data rates over these wireless links. Rate adaptive signaling is a powerful way to design a robust system across such broad range of channel conditions because the system will not have to be designed for the worst case scenario and system resources can be utilized more efficiently. In this paper, we apply our previously proposed rate adaptive OFDM spread spectrum system concept to a LEO satellite (LEOS) communications application. We demonstrate the feasibility of rate adaptation by analyzing the link margin of a LEOS link characterized by free space loss, multipath fading and interference. A Doppler based rate adaptation algorithm is proposed to constantly measure and predict the mobile terminal received signal strength and to control the system processing gain accordingly. Desired system performance can be maintained across a large dynamic range of signal strength by the proper control of the processing gain.
Developmental and Neurologic Status of Children after Heart Surgery with Hypothermic Circulatory Arrest or Low-Flow Cardiopulmonary Bypass (1995)

Heart surgery performed with circulatory arrest as the predominant support strategy is associated with a higher risk of delayed motor development and neurologic abnormalities at the age of one year than is surgery with low-flow bypass as the predominant support strategy.
Microbial growth and accumulation in industrial metal-working fluids (1989)

The dynamics of microbial growth in metal-working fluids (MWF) and the effect of the addition of biocides were studied in large fluid systems, in this case, one central tank which holds 150 m3. In this system, populations of Pseudomonas pseudoalcaligenes (greater than 10(8) CFU/ml) were sustained for a year, although large quantities of biocides were added. Quantitation of 3-OH lauric acid, a marker for many Pseudomonas spp., by gas chromatography indicated that the bacterial biomass exceeded the viable counts by approximately 15 times. Fungi were grown on several occasions, the dominating genera being Fusarium and Candida. Soon after the old MWF was removed and the tank was provided with fresh MWF, which consisted of an emulsion of mineral oil in water, there was a massive growth of P. pseudoalcaligenes that reached levels of greater than 10(8) bacteria per ml. Initially, only low concentrations of other species were found for some weeks. After this period, different enterobacteria and other gram-negative rods often appeared at high concentrations (10(7) and 10(8) bacteria per ml, respectively). Bacteria identified as P. pseudoalcaligenes showed great variation with respect to colony morphology and a certain heterogeneity with respect to biochemical characteristics. Certain bacterial species grew as microcolonies on metal strips immersed in the circulating MWF, but P. pseudoalcaligenes was not recovered from this habitat. The total bacterial count in the air surrounding the machines in the metal-working shop showed an inverse relation to increasing distance from the machine. The concentration of bacteria in the air varied because of the number of machines in use, temperature, and humidity.(ABSTRACT TRUNCATED AT 250 WORDS)
Predictive Models for Condensate Gas Ratio (CGR) – Part 1: For Western Niger Delta Region (2013)

Condensate-to-gas ratio (CGR) plays a significant role in sales potential assessment of both gas and liquid, design of the required surface processing facilities, reservoir characterization and modeling in gas-condensate reservoirs. This work aim at the use of regression method to develop Condensate gas ratio (CGR) correlations using dataset obtained from Western Niger Delta region. The formation was divided into three distinct geologic zones: Transitional Paralic, Paralic and Marine Paralic zones. The basic parameters used for the correlation development are: reservoir depth (ft), reservoir pressure (psia); reservoir temperature ( o F) all at (Gas -Oil -Contact (GOC) / Gas -Down -To (GDT) / Gas -Water -Contact (GWC)) and these parameters are data easily obtained from the field. A statistical assessments show that the models predicted CGR with a percent mean absolute error of 19.5640, correlation coefficient of 0.9539 and a rank of 18.15. These results show that the models are suitable for these fields.
Application of Synthetic Mica to Cosmetics. (1995)

Fluormicas have been synthesized by an internal resistance electric melting method. Because of their sizes and stable structures of the crystals those synthetic micas had a potential for cosmetic use. In them, synthetic fluorphlogopite(FPG)has been studied to be the best mica for cosmetics.The fluorphlogopite is chemically pure, and has a excellent lubricity and adhesiveness. The authors established the methods of its synthesis and pulverizing for cosmetic use.
The Potential for Cost Savings through Bundled Episode Payments (2012)

A key question about aggregating payments to health care providers is determining whether to bundle services for individual, if extended, episodes of care or for whole patients. What are the tradeoffs of the two approaches, and how much money could be saved?
Polyampholyte Nanoparticles Prepared by Self‐Complexation of Cationized Poly(<i>γ</i>‐glutamic acid) for Protein Carriers (2012)

A novel amphoteric poly(amino acid) is synthesized by grafting a cationic amino acid (L-Arg) to γ-PGA to prepare charged NPs. γ-PGA-Arg NPs can be prepared by the self-complexation of a single polymer by intra-/inter-molecular electrostatic interactions when the polymer is dispersed in water. The size and surface charge of the NPs can be regulated by the grafting degree of Arg (41, 56, and 83%). The smallest NPs are obtained at 56% grafting degree of the γ-PGA-Arg copolymer. The 56 and 83% grafting degree NPs are stable for at least 1 week. Depending on their surface charge, these NPs can selectively adsorb anionically or cationically charged proteins.
Automated Critical Peak Pricing Field Tests: 2006 Pilot Program Description and Results (2007)

Automated Critical Peak Pricing Field Tests: 2006 Pilot Program Description and Results Mary Ann Piette David Watson Naoya Motegi Sila Kiliccote Lawrence Berkeley National Laboratory MS90R3111 1 Cyclotron Road Berkeley, California 94720 June 19, 2007 LBNL Report Number 62218
Comparativo de Ferramentas Proprietaria e Software Livre de Gerencia de Projetos (2015)

Com o aumento do uso da tecnologia em nossas vidas como um todo, a demanda por softwares cresce a cada dia. Essa demanda esta se tornando cada vez mais especifica dependendo do tema abordado. Sendo assim existem boas praticas para o desenvolvimento destes softwares. Um seguimento destas praticas consiste em gerenciar e fazer a gestao de tudo que e feito. Pensado no mundo em que vivemos, onde a preocupacao com o capital e muito importante, realizar essa gerencia se torna mais do que uma pratica e sim um meio vital para a sobrevivencia de qualquer atividade ou projeto. Este processo de gestao dos projetos pode ser facilitado pelo uso de ferramentas de Gerencia de Projetos. A proposta deste trabalho e comparar o estagio de amadurecimento das ferramentas de software livre com as proprietarias.
Differential expression and sequence analysis of the maize glyceraldehyde-3-phosphate dehydrogenase gene family. (1989)

Two cDNA clones for maize cytosolic glyceraldehyde-3-phosphate dehydrogenase are described. One is about 97% similar in coding capacity to a previously published clone [Brinkmann et al. (1987). J. Mol. Evol. 26, 320-328], while the other shows only 88% similarity. Evidence points toward the three cDNAs being the products of three genes, to be called Gpc1, Gpc2, and Gpc3. When the least similar clone, corresponding to Gpc3, was used to analyze RNA gel blots, anaerobic treatment for 6 hours induced RNA accumulation in the shoots 15.6-fold, while a 1-hour shift from 28 degrees C to 40 degrees C increased accumulation 5.1-fold. Roots had a higher basal level of expression, leading to a 6.0-fold anaerobic induction, and a 2.4-fold heat stress induction. RNA gel blot analysis using the clone corresponding to Gpc2 showed decreased RNA accumulation within 6 hours of anaerobiosis, while analysis with the previously published clone, corresponding to Gpc1, showed a decrease within 24 hours. Neither Gpc1 nor Gpc2 showed heat stress induction, while some other known anaerobic genes did. Through the use of hybrid selection, in vitro translation, and immune precipitation, the relative expression of the three genes is shown. The role of the observed changes in gene expression is discussed in relation to stress physiology.
Phenylpyruvate Contributes to the Synthesis of Fragrant Benzenoid–Phenylpropanoids in Petunia × hybrida Flowers (2017)

Phenylalanine (Phe) is a precursor for a large group of plant specialized metabolites, including the fragrant volatile benzenoid-phenylpropanoids (BPs). In plants, the main pathway leading to production of Phe is <i>via</i> arogenate, while the pathway <i>via</i> phenylpyruvate (PPY) is considered merely an alternative route. Unlike plants, in most microorganisms the only pathway leading to the synthesis of Phe is <i>via</i> PPY. Here we studied the effect of increased PPY production in petunia on the formation of BPs volatiles and other specialized metabolites originating from Phe both in flowers and leaves. Stimulation of the pathway <i>via</i> PPY was achieved by transforming petunia with <i>PheA<sup>∗</sup></i> , a gene encoding a bacterial feedback insensitive bi-functional chorismate mutase/prephenate dehydratase enzyme. <i>PheA<sup>∗</sup></i> overexpression caused dramatic increase in the levels of flower BP volatiles such as phenylacetaldehyde, benzaldehyde, benzyl acetate, vanillin, and eugenol. All three BP pathways characterized in petunia flowers were stimulated in <i>PheA<sup>∗</sup></i> flowers. In contrast, <i>PheA<sup>∗</sup></i> overexpression had only a minor effect on the levels of amino acids and non-volatile metabolites both in the leaves and flowers. The one exception is a dramatic increase in the level of rosmarinate, a conjugate between Phe-derived caffeate and Tyr-derived 3,4-dihydroxyphenylacetate, in PheA<sup>∗</sup> leaves. <i>PheA<sup>∗</sup></i> petunia flowers may serve as an excellent system for revealing the role of PPY in the production of BPs, including possible routes directly converting PPY to the fragrant volatiles. This study emphasizes the potential of the PPY route in achieving fragrance enhancement in flowering plants.
ROR1-Specific Chimeric Antigen Receptor (CAR) NK Cell Immunotherapy for High Risk Neuroblastomas and Sarcomas (2017)

Background: Patients with Neuroblastoma (NB) and Sarcoma (SC) who fail chemoradiotherapy have a dismal prognosis and poor long-term survival (≤30% OS). Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is highly expressed on the majority of NB and SC. NK cells can be expanded by co-culture with genetically engineered K562 cells with membrane bound IL-21 (Lee D, PLoS ONE, 2012). We have previously demonstrated success of mRNA electroporation methodology to transfect CAR into NK cells (Chu/Cairo, Can Imm Res, 2015). Targeted cellular therapy with CAR NK cells may be an alternative approach for patients with relapsed and refractory NB and SC. Objective: We hypothesize that ROR1 CAR NK cells by mRNA transfection will be highly effective against NB and SC expressing ROR1. Methods: To test our hypothesis, PBNK were expanded with lethally irradiated K562 Cl9.mb-IL21, and ex-vivo expanded PBNK cells (aNK) were electroporated with anti-ROR1-CAR mRNA with a 4-1BB signaling domain which is synthesized in vitro. Functional cytotoxic activity of anti-ROR1 CAR aNK cells against NB and SC cell lines was examined via 7-AAD/5-(6)-carboxyfluorescein diacetate succinimidyl ester (CFSE) cell-mediated cytotoxicity assay at different E:T ratios. Anti-ROR1 specificity of CAR aNK cells was demonstrated using ROR1 negative NB cells (by shRNA knock down) and ROR1 negative MCF-7 cells. Expression of CD107a and intracellular IFN-g were examined using MACSQuant flow cytometer. Results: Flow cytometry demonstrated ROR1 is highly expressed in most of NB and SC cell lines including Ewing sarcoma, osteosarcoma and fibrosarcoma. CD56+CD3− PBNK cells were significantly propagated to large numbers by co-culture with irradiated K562-derived mbIL21-expressing aAPC at 14 days (2000 fold) (P = .002; Figure 1A), and expanded NK cells were isolated with more than 95% purity. Anti-ROR1-CAR was expressed on up to 70% of anti-ROR1 mRNA-transfected aNK cells (Figure 1B). aNK in vitro cytotoxicity was significantly enhanced by anti-ROR1-CAR-aNK compared to Mock-aNK against ROR1+ SHSY5Y, SKNBE(2)N, and SKNFI NB cells and U2OS SC cells at different E:T ratios (Figure 2A,B). However, ROR1-CAR aNK cells were not cytotoxic against ROR1 negative MCF-7 cells (Figure 2C) or SHSY5Y NB cells when ROR1 was knocked down by shRNA. In addition, expression of CD107a and IFN-g were significantly increased in ROR1-CAR aNK cells compared to Mock-aNK against ROR1+ NB cells (P < .05).Figure 2ROR1-CAR-aNK cells had a specific cytotocixity against ROR1 positive Neuroblastoma (A) and Sarcoma cells (B) compared to ROR1 negative expressed cells in vitro (C).View Large Image Figure ViewerDownload Hi-res image Download (PPT) Conclusion: These data demonstrated that electroporation with ROR1-CAR significantly increases in vitro cytotoxicity of aNK cells against ROR1 positive solid tumor cells. Future studies will investigate that approach in Xenografts and PDX in vivo models.
Simple and High Yielding Method for Preparing Tissue Specific Extracellular Matrix Coatings for Cell Culture (2010)

This versatile method can create tissue-specific ECM coatings, which offer a promising platform for cell culture to more closely mimic the mature in vivo ECM microenvironment.
Metal–Organic Framework (MOF) Defects under Control: Insights into the Missing Linker Sites and Their Implication in the Reactivity of Zirconium-Based Frameworks (2015)

For three-dimensional (3D) metal-organic frameworks (MOFs), the presence and nature of structural defects has been recognized as a key factor shaping the material's physical and chemical behavior. In this work, the formation of the "missing linker" defects has been addressed in the model biphenyl-4,4'-dicarboxylate (bpdc)-based Zr MOF, UiO-67. The defect showed strong dependence on the nature of the modulator acid used in the MOF synthesis; the defects, in turn, were found to correlate with the MOF physical and chemical properties. The dynamic nature of the Zr6 (node)-monocarboxylate bond showed promise in defect functionalization and "healing", including the formation of X-ray-quality "defect-free" UiO-67 single crystals. Chemical transformations at defect sites have also been explored. The study was also extended to the isoreticular UiO-66 and UiO-68' systems.
Redundant Sensors for Mobile Robot Navigation (1985)

Abstract : Redundant sensors are needed on a mobile robot so that the accuracy with which it perceives its surroundings can be increased. Sonar and infrared sensors are used here in tandem, each compensating for deficiencies in the other. The robot combines the data from both sensors to build a representation which is more accurate than if either sensor were used alone. Another representation, the curvature primal sketch, is extracted from this perceived workspace and is used as the input to two path planning programs: one based on configuration space and one based on a generalized cone formulation of free space. (Author).
Verification of sliding mesh algorithms for complex applications using MMS. (2020)

Abstract not provided.
Photodynamic therapy with verteporfin: A new treatment in ophthalmology (2001)

Photodynamic therapy (PDT) with verteporfin is a new treatment modality in ophthalmology that has previously shown its effectiveness in treatment of a variety of neoplastic pathologies. In this therapeutic approach, the photosensitizer verteporfin is activated by non-thermal laser light to obtain closure of neovascular structures. Preclinical and clinical studies have indicated that PDT is a safe, selective, and effective treatment for choroidal neovascularization in age-related macular degeneration. No significant damage to the neurosensory retina was found, which explains why PDT does not cause loss of visual acuity and may be used in a larger population than laser photocoagulation. This review summarizes the mechanisms of action of PDT, and the results of preclinical and clinical studies in ophthalmology.
Phosphine-Catalyzed Synthesis of 6-Substituted 2-Pyrones:  Manifestation of <i>E</i>/<i>Z</i>-Isomerism in the Zwitterionic Intermediate (2005)

[reaction: see text] We report a one-step phosphine-catalyzed annulation between aldehydes and ethyl allenoate to form 6-substituted 2-pyrones. The mechanistic rationale for this reaction requires explicit discussion of the E/Z-isomerism of the zwitterionic intermediate formed by the addition of a phosphine to the allenoate. Sterically demanding trialkylphosphines facilitate the shift of equilibrium toward the E-isomeric zwitterion and lead to the formation of 6-substituted 2-pyrones. Various aromatic as well as aliphatic aldehydes undergo the transformation in moderate to excellent yield.
Doxycycline Hyclate Treatment of Experimental Canine Ehrlichiosis Followed by Challenge Inoculation with Two<i>Ehrlichia canis</i>Strains (1998)

Dogs were experimentally inoculated with Ehrlichia canis Florida to assess the efficacy of doxycycline hyclate for the treatment of acute ehrlichiosis. Treatment with doxycycline eliminated infection in eight of eight dogs. Untreated infected control dogs appeared to eliminate the infection or, alternatively, suppress the degree of ehrlichiemia to a level not detectable by tissue culture isolation or PCR or by transfusion of blood into recipient dogs. Prior infection did not infer protection against homologous (strain Florida) or heterologous (strain NCSU Jake) strains of E. canis. We conclude that doxycycline hyclate is an effective treatment for acute E. canis infection; however, these results may not be applicable to chronic infections in nature. Spontaneous resolution of infection, induced by the dog's innate immune response, provides evidence that an E. canis vaccine, once developed, might potentially confer protective immunity against the organism.
A General Systems Approach to Decision‐Making in Schools (1968)

Educational administration still relics greatly on “wise” generalizations from the experiences of outstanding practitioners. Hence, a great many decisions in educational practice are still at the “professional lore” level. With the rapid expansion in knowledge, emphasis has tended to shift to the expert and the technician. Nevertheless, value decisions should not be permitted to be eroded. The educational decision‐maker needs to be both humanist and scientist. A rational basis exists for such a nexus. There is need for the joint operation of knowledge and value systems in decision‐making Both systems pass from the rather uncritical “Common Sense Stage” through the Empirical to the Scientific Stage. Self‐conscious rational action becomes possible only at the Scientific Stage. It is only within comparatively recent times that decision‐making in education has begun to move into the Scientific Stage, primarily because scientific knowledge about human behaviour is largely a product of this century. A decision is seen to be concerned primarily with predictions of future events that are desirable to people. The decision process involves (1) monitoring, (2) control (diagnosis, selection, transformation) and (3) action.