gebhart/patrepeval huggingface dataset:
The Influence of Directly Modulated DFB Lasers on the Transmission Performance of Carrier-Suppressed Single-Sideband Optical OFDM Signals Over IMDD SMF Systems (2009)

The transmission performance of carrier-suppressed, single-sideband (SSB), optical orthogonal frequency division multiplexing (OOFDM) signals is investigated numerically in intensity-modulation and direct-detection (IMDD) single-mode fiber (SMF) systems using directly modulated DFB lasers (DMLs), with special attention being given to the impact of DMLs on the system performance. The dependence of the optimum carrier suppression ratio is identified on DML operating condition and optical input power. It is shown that, for DML-based optical amplification-free metropolitan systems, 30 Gb/s over 80-km SMF transmission is achievable, which doubles the performance obtained by using double-sideband (DSB) OOFDM signals without carrier suppression, and that 10 Gb/s over 1200-km SMF transmission is also feasible for DML-based long-haul systems consisting of optical amplifiers. The results indicate that the SSB technique with an optimum carrier suppression ratio reduces considerably the DML-induced nonlinear effect, and leads to decreased susceptibility of the aforementioned transmission performance to variations in DML operating condition and optical input power.
Display Devices: RSD™ (Retinal Scanning Display) (2014)

This chapter relates performance, safety, and utility attributes of the retinal scanning display as employed in a helmet-mounted pilot-vehicle interface, and by association, in panel-mounted head up display and head down display applications. The Retinal Scanning Display (RSD) offers distinct advantages over other display technologies because image quality and color gamut are maintained at high luminances limited only by eye-safety considerations. The light-concentrating aspect of the diffraction-limited laser beam can routinely produce source luminances that exceed that of the solar disc. Inappropriate mounting of fixed fold mirrors in the projection path led to the accumulation of several wavelengths of wave-front error and resultant image blurring. An effort of 30 years has only scratched the surface of the head mounted display’s pilot vehicle interfacing potential. It is expected that the RSD will open new avenues of pilot-in-the-loop research and enable safer, more effective air and ground operations.
Career Development and Systems Theory (2014)

Career Development and Systems Theory: Connecting Theory and Practice offers practitioners, researchers and students a comprehensive introduction to, and overview of, career theory; introduces the Systems Theory Framework of career development; and demonstrates its considerable contemporary and innovative application to practice. A number of authors have identified the framework as one of a small number of significant innovations in the career development literature. The Systems Theory Framework of career development was developed to provide coherence to the career development field by providing a comprehensive conceptualisation of the many existing theories and concepts relevant to understanding career development. It is not designed to be a theory of career development; rather systems theory is introduced as the basis for an overarching, or metatheoretical, framework within which all concepts of career development, described in the plethora of career theories, can be usefully positioned and utilised in both theory and practice. It has been applied to the career development of children, adolescents and women. Since its first publication, the Systems Theory Framework has been the basis of numerous publications focusing on theoretical application and integration, practice and research, with a growing number of these by authors other than the framework developers. Its application across cultures also has been emphasised. The theoretical and practical unity of the Systems Theory Framework makes this book a worthy addition to the professional libraries of practitioners, researchers and students, new to, or experienced in, the field of career development.
Novel Small Molecule Bradykinin B <sub>2</sub> Receptor Antagonists (2009)

Blockade of the bradykinin B(2) receptor provides therapeutic benefit in hereditary angioedema (HAE) and potentially in many other diseases. Herein, we describe the development of highly potent B(2) receptor antagonists with a molecular weight of approximately 500 g/mol. First, known quinoline-based B(2) receptor antagonists were stripped down to their shared core motif 53, which turned out to be the minimum pharmacophore. Targeted modifications of 53 resulted in the highly water-soluble lead compound 8a. Extensive exploration of its structure-activity relationship resulted in a series of highly potent B(2) receptor antagonists, featuring a hydrogen bond accepting functionality, which presumably interacts with the side chain of Asn-107 of the B(2) receptor. Optimization of the microsomal stability and cytochrome P450 inhibition eventually led to the discovery of the highly potent and orally available B(2) receptor antagonist 52e (JSM10292), which showed the best overall properties.
<title>Approaching the theoretical x-ray sensitivity with Hgl<formula><inf><roman>2</roman></inf></formula> direct detection image sensors</title> (2002)

The x-ray response of polycrystalline HgI2 for direct detection x-ray imagers, is studied using test arrays with 512 X 512 pixels of size 100 micron. We quantify the contributions to the x-ray sensitivity from electron and hole charge collection, x-ray absorption, effective fill factor and image lag, for x-ray energies from 25-100 kVp. The data analysis compares the measured sensitivity to the theoretical limit and identifies the contributions from various loss mechanisms. The sensitivity is explained by the ionization energy of approximately 5 eV, coupled with small corrections arising from incomplete x-ray absorption, incomplete charge collection, and image lag. Hence, imagers with HgI2 approach the theoretical maximum response for semiconductor detectors, with external array sensitivity demonstrated to within 50 percent of the limit.
Spin injection into a ballistic semiconductor microstructure (2003)

A theory of spin injection across a ballistic semiconductor embedded between two ferromagnetic leads is developed for the Boltzmann regime. Spin injection coefficient $\ensuremath{\gamma}$ is suppressed by the Sharvin resistance of the semiconductor ${r}_{N}^{*}{=(h/e}^{2})({\ensuremath{\pi}}^{2}{/S}_{N}),$ where ${S}_{N}$ is the Fermi-surface cross section. It competes with the diffusion resistances of the ferromagnets ${r}_{F},$ and $\ensuremath{\gamma}$ is small, $\ensuremath{\gamma}\ensuremath{\sim}{r}_{F}{/r}_{N}^{*}\ensuremath{\ll}1,$ in the absence of contact barriers. Efficient spin injection can be ensured by contact barriers. Explicit formulas for the junction resistance and the spin-valve effect are presented.
Low dose CT image restoration using a localized patch database (2013)

As growing concerns on the potential side effect of radiation induced genetic, cancerous and other diseases, the low-dose CT imaging is becoming a hot issue, how to minimize the radiation exposure level while maintaining the diagnostic performance. In previous work, we have proposed a framework that is working in conjunction with image-based database. It restores a low-dose image with modified non-local means (NLM) that have expanded search window to include regular-dose priors obtained from same or different patients. In this paper, we further develop the framework to know the internal structures of CT images so that the NLM filtering is applied with more intelligent way. In addition, knowing the internal structures changes the database from image-based to patch-based that organized structure by structure. As preliminary work, this was tested to restore a structure of low-dose CT image and it showed a very promising results.
197. Survival, Growth, and Neurobehavioral Outcomes in a Mouse Model of Menkes Disease With CSF-Directed AAV9 and Subcutaneous Copper Histidine (2015)

Menkes disease is a X-linked recessive neurometabolic disorder with high morbidity and mortality caused by a defective transmembrane copper transporter, ATP7A. The mottled-brindled (mo-br), a Menkes mouse model, has afforded the chance to compare clinical, biochemical, and pathological outcomes in response to specific therapeutic interventions, including rAAV5-, rAAVrh10-, and most recently, rAAV9-ATP7A viral gene therapy. The rAAV9 and rAAVrh.10 serotypes show broader neuronal tropism than rAAV5 and may gain access to the brain after systemic administration. However, the seroprevalence of maternally transmitted neutralizing antibodies against AAV in human infants from birth to 6 months suggests that peripheral administration could be suboptimal in our target population. Thus, cerebrospinal fluid (CSF)-directed rAAV9- or rAAVrh.10-ATP7A appear to represent a more suitable choice from both immunological and tissue target perspectives. In mo-br mice, we evaluated intracerebroventricular administration of rAAV9- and rAAVrh10-ATP7A, using low, medium, and high doses in affected mutants on day 2 of life, with 15 μg of clinical grade copper histidine given by subcutaneous injection between d4 and d10. Survival data from a cohort of 40 mo-br mice documented that intermediate (5.0×109 vg) and high (1.6×1010 vg) rAAV9-ATP7A doses were most effective. In correlation with the best survival benefit, CSF-directed rAAV9 + subcutaneous Cu resulted in superior murine neurobehavioral outcomes and “catch-up” growth compared to results with other serotypes, reported previously. In addition, mutant mice treated with high dose AAV9+Cu showed the highest brain viral genome copies, and markedly improved brain neurochemical and brain copper levels in comparison to untreated mutants. Brain copper measurements in combination-treated mutants (d12) were not statistically different in comparison to wild type littermates. Based on our combined data, we propose rAAV9 as a serotype of choice for first-in-human intrathecal administration in patients with Menkes disease.
Effect of essential oil compound on shedding and colonization of Salmonella enterica serovar Heidelberg in broilers (2013)

The objectives of this study were to determine the effect of an essential oil blend (EO; carvacrol, thymol, eucalyptol, lemon) administered in drinking water on the performance, mortality, water consumption, pH of crop and ceca, and Salmonella enterica serovar Heidelberg fecal shedding and colonization in broiler birds following Salmonella Heidelberg challenge and feed withdrawal. Chicks were randomly assigned to water treatments containing 0.05, 0.025, or 0.0125% EO or untreated controls. Treatments were administered in drinking water on 0 to 7 and 35 to 42 d. One-half of the chicks were challenged with Salmonella Heidelberg and placed in pens with unchallenged chicks on d 1. Performance, mortality, water consumption, and pH were determined during the 42-d study. Prevalence of Salmonella Heidelberg was determined on drag swabs (0, 14, and 42 d) and in the ceca and crops (42 d). The 0.05% EO administered in drinking water significantly (P < 0.05) reduced Salmonella Heidelberg colonization in crops of challenged birds, significantly lowered the feed conversion ratio, and increased weight gain compared with controls. The 0.025% and 0.015% EO in drinking water significantly lowered the feed conversion ratio and increased weight gain compared with controls, but did not significantly reduce Salmonella Heidelberg colonization in the crops. The EO in drinking water did not significantly reduce Salmonella Heidelberg colonization in ceca or fecal shedding in broilers. The EO used in the study may control Salmonella Heidelberg contamination in crops of broilers when administered in drinking water and therefore may reduce the potential for cross-contamination of the carcass when the birds are processed.
Pulsatile Operation of a Centrifugal Ventricular Assist Device With Magnetic Bearings (1996)

A prototype bench top model of a continuous flow ventricular assist device using an impeller suspended by magnetic bearings has been developed. Generation of a pulsatile pressure was studied using both a computer model and in vitro loop tests of the prototype. The motivation for developing a computer model for a blood pump in the natural circulation is two-fold. First, it allows simulation of the pump under a large variety of operating conditions. Second, it provides insight into what parameters of the system design are important for achieving a specific result. For example, in one case, an aortic pressure of 118/87 mmHg was generated by varying the speed from 2,000 to 2,600 rpm. The computer model was verified by coupling the centrifugal pump prototype to a mock circulatory system. The results of the model were verified by generating an aortic pressure of 113/78 mmHg while varying the speed from 2,000 to 2,600 rpm. These experiments have shown that it is possible to generate pulsatile pressure similar to that of native physiology using a centrifugal left ventricular assist device. Further tests will be required to quantify the effects on hemolysis.
Three‐ and Four‐Coordinate, Boron‐Based, Thermally Activated Delayed Fluorescent Emitters (2020)

Abstract Recent developments in purely organic‐material‐based thermally activated delayed fluorescence (TADF) emitters are helping to make them suitable for commercial applications in the near future. In spite of their high external quantum efficiencies, the broad emission spectra and short device lifetimes are the main barriers to using TADF emitters. Among the classes of materials, boron‐embedded polycyclic aromatic compounds have shown potential as TADF emitters that overcome the technical issues. In particular, highly efficient boron‐based TADF emitters with the advantage of a narrowband emission spectrum have been reported recently relying on the concept of a multi‐resonance effect. Hence, boron TADF emitters have the potential to become next‐generation emitters. Based on the future scope of the boron‐based TADF emitters (especially in development of blue TADF emitters), three‐ and four‐coordinate boron TADF emitters are reviewed. Additionally, future prospects of boron‐based TADF emitters are discussed to resolve the issues of low efficiency and short lifetimes of blue emitters.
GnRH Analogs in Gynecological Oncology: a Review (1992)

Chronic GnRH analogs (GnRH-A) administration has proven to be effective for the control of some hormone-dependent tumors. GnRH-A are now in the standard treatment of prostatic cancer. In the present paper experimental and clinical data on the use of GnRH-A in gynecologic oncology are reviewed in order to identify a possible role in the therapy of breast, endometrial and ovarian cancer. Besides the indirect hormonal effect of GnRH-A, mediated by the suppression of gonadal steroidogenesis, in vitro evidence suggests a direct anti-proliferative action involving autocrine-paracrine regulation of cellular function. In advanced or recurrent breast cancer objective responses were observed in 157 out of 378 premenopausal patients (41%) and in 18 out of 166 postmenopausal women (10%). In ovarian cancer complete and partial responses were observed in 14 out of 121 (11%). At present, data on advanced endometrial carcinoma are limited: only 18 treated patients are reported, of whom 7 responded (38.8%). However, in general, most of the responses observed were transient. Thus, so far, the use of GnRH-A in gynecologic oncology has to be considered for palliation, after the failure of other better understood treatment modalities. The possible use of GnRH-A as an adjuvant is still under investigation.
Connecting the quantum dots (2010)

In this paper, paints, an optoelectronic materials were used to make better photovoltaic cells, imaging sensors, and optical communication equipment by considering the nanomaterial design understanding at a molecular level. Infrared solar cells from semiconductor quantum dots were developed and the paint-on technology for other device applications were also discussed.
Data center energy cost minimization: A spatio-temporal scheduling approach (2013)

Cloud computing is supported by an infrastructure known as Internet data center (IDC). As cloud computing thrives, the energy consumption and cost for IDCs are exploding. There is growing interest in energy cost minimization for IDCs in deregulated electricity markets. In this paper we study how to leverage both geographic and temporal variation of energy price to minimize energy cost for distributed IDCs. To this end, we propose a novel spatio-temporal load balancing approach. Using reallife electricity price and workload traces, extensive evaluations demonstrate that the proposed spatio-temporal load balancing approach significantly reduces energy cost for distributed IDCs.
Genetic mapping of the β<sub>1</sub>- and γ-subunits of the human skeletal muscle L-type voltage-dependent calcium channel on chromosome 17q and exclusion as candidate genes for malignant hyperthermia susceptibility (1993)

Malignant hyperthermia susceptibility (MHS) is an autosomal dominant disorder of skeletal muscle which manifests as a life-threatening hypermetabolic crisis triggered by commonly-used inhalation anaesthetics and depolarizing muscle relaxants. Defects in the ryanodine receptor (RYR1) protein have been proposed to underly MHS, but significant genetic heterogeneity in MHS has recently been demonstrated. In order to investigate the potential roles played by other skeletal muscle calcium channels in MHS, we isolated cosmids containing the gene encoding the beta 1-subunit of skeletal muscle L-type voltage-dependent calcium channel (CACNLB1). We identified a new, highly polymorphic dinucleotide repeat motif close to this gene, and linkage analysis placed the marker proximal to the HOX2B locus, previously localized to chromosome segment 17q21-q22. We recently identified a novel marker within the gamma-subunit locus (CACNLG) at band 17q24, and since both markers are within the 17q11.2-q24 region reported to contain the MHS2 locus, we tested them for linkage in MHS families whose disease trait has been shown not to co-segregate with markers for the RYR1 region on chromosome 19q13.1. Our results exclude CACNLB1 and CACNLG as candidate genes for MHS2, and do not support the reported chromosome 17q localization for the MHS2 locus in our families.
A Computational Model of Perceived Agency in Video Games (2011)

Agency, being one's ability to perform an action and have some influence over the world, is fundamental to interactive entertainment. Although much of the games industry is concerned with providing more agency to its players, what seems to matter more is how much agency each player will actually perceive. In this paper, we present a computational model of this phenomena, based on the notion that the amount of agency that one perceives depends on how much they desire the outcomes that result from their decisions. Using a structure for high-agency stories that we designed specifically for this intent, we present the results of a 141-participant user study that tests our model's ability to select subsequent events in an original interactive story. Using a newly validated survey instrument for measuring both agency and fun, we found with a high degree of confidence that event sequences selected by our model result in players perceiving more agency than players who experience event sequences that our model does not recommend.
Structure Loaded Vacuum Laser-Driven Particle Acceleration Experiments at SLAC and Possible Applications (2007)

Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text T. Plettner, "Structure Loaded Vacuum Laser-Driven Particle Acceleration Experiments at SLAC and Possible Applications," in Conference on Lasers and Electro-Optics/Quantum Electronics and Laser Science Conference and Photonic Applications Systems Technologies, OSA Technical Digest (CD) (Optica Publishing Group, 2007), paper PThB3. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
SIZING AGENT RECOVERY BY MEMBRANE ULTRAFILTRATION IN HOLLOW-FIBER MODULES (2000)

Ultrafiltration of an aqueous solution of polyvinyl alcohol was carried out in an Amicon model H1P30-20 hollow-fiber cartridge made of polysuifone. Fresh water was forced through the macroporous membrane, as the permeate, while polyvinyl alcohol was concentrated and re covered as the retentate. Correlation equations for calculating the permeate flux of membrane ultrafiltration of the polyvinyl alcohol were derived based on the resistance-in-series and exponential models. Correlation results were confirmed by the experimental data, especially for the results obtained from the exponential model. It was found that the permeate flux increases as transmembrane pressure or fluid velocity increases, but decreases when feed concentration increases. Because membrane ultrafiltration is a pressure-driven process, high cross-flow velocity enhances the mass transfer coefficient of the solute and high solution concentration in creases the thickness of the concentration polarization layer.
The Rendezvous Mechanism for the Multi-core AMBA System (2009)

The complex architectures of the signal core have the bottlenecks to improve performance. The homogenous and heterogeneous multi-core architecture will be the further trends. For the job's cooperation, the synchronous behaviors are needed to keep the task achievements and, more frequently, occur in the multi-core systems. Polling and interrupt usually used as the inter-processor communication mechanisms among multi-cores, and they will cause the heavy bus traffic and more cycle loss for the context switching. In this paper, we have proposed a rendezvous mechanism and implement it at the AHB, called RAHB. In RAHB, the slave organizations will be added in each core's AHB interface. When the data is not ready, the core will be waiting and regarded as a slave device on bus. By this way, the synchronization will be constructed with the load-store instructions among multi-cores without polling mechanisms or interrupt handlers. Because the RAHB reduce the conflicts on the bus and cycle loss, simulation results show that the performance will be improved about the speedup 30% approximately. The core locked hazard had also been considered and avoided by the aging mechanism in this design.
A novel biodegradable stent applicable for use in congenital heart disease: Bench testing and feasibility results in a rabbit model (2013)

In vitro results of DH PLLA biodegradable stents are comparable to conventional metal stents. The pilot animal study confirms the delivery and deployment of the DH stents to the desired location. The DH design can be used to fabricate larger diameter stents needed for CHD.
Synthesis and Properties of Highly Dispersed Ionic Silica–Poly(ethylene oxide) Nanohybrids (2013)

We report an ionic hybrid based on silica nanoparticles as the anion and amine-terminated poly(ethylene oxide) (PEO) as a cation. The charge on the nanoparticle anion is carried by the surface hydroxyls. SAXS and TEM reveal an exceptional degree of dispersion of the silica in the polymer and high degree of order in both thin film and bulk forms. In addition to better dispersion, the ionic hybrid shows improved flow characteristics compared to silica/PEO mixtures in which the ionic interactions are absent.