gebhart/patrepeval huggingface dataset:
Peripheral Blood–Derived Virus-Specific Memory Stem T Cells Mature to Functional Effector Memory Subsets with Self-Renewal Potency (2015)

Memory T cells expressing stem cell-like properties have been described recently. The capacity of self-renewal and differentiation into various memory/effector subsets make them attractive for adoptive T cell therapy to combat severe virus infections and tumors. The very few reports on human memory stem T cells (T(SCM)) are restricted to analyses on polyclonal T cells, but extensive data on Ag-specific T(SCM )are missing. This might be due to their very low frequency limiting their enrichment and characterization. In this article, we provide functional and phenotypic data on human viral-specific T(SCM), defined as CD8(+)CD45RA(+)CCR7(+)CD127(+)CD95(+). Whereas <1% of total T cells express the T(SCM) phenotype, human CMV-specific T(SCM) can be detected at frequencies similar to those seen in other subsets, resulting in ∼ 1 /10,000 human CMV-specific T(SCM). A new virus-specific expansion protocol of sort-purified T(SCM) reveals both upregulation of various T cell subset markers and preservation of their stem cell phenotype in a significant proportion, indicating both self-renewal and differentiation potency of virus-specific T cells sharing their TCR repertoire. Furthermore, we describe a simplified culture protocol that allows fast expansion of virus-specific T(SCM) starting from a mixed naive T/T(SCM) pool of PBLs. Due to the clinical-grade compatibility, this might be the basis for novel cell therapeutic options in life-threatening courses of viral and tumor disease.
1V high-speed digital circuit technology with 0.5μm multi-threshold CMOS (2002)

A 1-V high-speed and low-power digital circuit technology with 0.5/spl mu/m multi-threshold CMOS (MT-CMOS) is proposed. This technology applies both low-threshold voltage and high-threshold voltage MOSFETs in one LSI. Low-threshold voltage MOSFETs enhance speed performance at a supply voltage of 1 V or less. High-threshold voltage MOSFETs suppress the stand-by leakage circuit during the sleep period. The technology has achieved logic gate characteristics of a 1.7-ns propagation delay time and 0.3-/spl mu/W/MHz/gate power dissipation. To demonstrate its effectiveness, a standard cell based PLL-LSI was designed as a carrying vehicle. An 18-MHz operation at 1 V was obtained using a 0.5-/spl mu/m MT-CMOS process.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Immature Copper-Zinc Superoxide Dismutase and Familial Amyotrophic Lateral Sclerosis (2009)

Mutations in human copper-zinc superoxide dismutase (SOD1) cause an inherited form of amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease, motor neuron disease). Insoluble forms of mutant SOD1 accumulate in neural tissues of human ALS patients and in spinal cords of transgenic mice expressing these polypeptides, suggesting that SOD1-linked ALS is a protein misfolding disorder. Understanding the molecular basis for how the pathogenic mutations give rise to SOD1 folding intermediates, which may themselves be toxic, is therefore of keen interest. A critical step on the SOD1 folding pathway occurs when the copper chaperone for SOD1 (CCS) modifies the nascent SOD1 polypeptide by inserting the catalytic copper cofactor and oxidizing its intrasubunit disulfide bond. Recent studies reveal that pathogenic SOD1 proteins coming from cultured cells and from the spinal cords of transgenic mice tend to be metal-deficient and/or lacking the disulfide bond, raising the possibility that the disease-causing mutations may enhance levels of SOD1-folding intermediates by preventing or hindering CCS-mediated SOD1 maturation. This mini-review explores this hypothesis by highlighting the structural and biophysical properties of the pathogenic SOD1 mutants in the context of what is currently known about CCS structure and action. Other hypotheses as to the nature of toxicity inherent in pathogenic SOD1 proteins are not covered.
Deformable mesh registration for the validation of automatic target localization algorithms (2013)

Provided that delineated surfaces are available, deformable mesh registration is an accurate and reliable method for obtaining a reference registration to validate automatic target registration algorithms for image-guided radiation therapy, specifically in regions on or near the target surfaces.
Non-Aqueous Redox Flow Batteries with Nickel and Iron Tris(2,2ʹ-bipyridine) Complex Electrolyte (2012)

An organic redox flow battery adopting tris(2,2'-bipyridine)nickel(II)tetrafluoroborate (Ni(Bpy)3(BF4)2) and tris(2,2'-bipyridine)iron(II)tetrafluoroborate (Fe(BPy)3(BF4)2)) in propylenecarbonate electrolyte is investigated. With cyclic voltammetry, the redox current of one-electron related Fe(II)/Fe(III) and two-electron related Ni(II)/Ni(0) appears at 0.65 V and −1.66 V (vs. Ag/Ag+), respectively and their cycleabilities are highly stable during 100 cycles. Their charge-discharge characteristics on the carbon-felt electrodes are evaluated with 0.4 M Fe(Bpy)3(BF4)2 and 0.2 M Ni(Bpy)3(BF4)2 which are adopted as catholyte and anolyte. Comparing with the aqueous system, the higher cell voltage of 2.2 V was achieved and initial coulombic and energy efficiencies were reached with 90.4 and 81.8%.
The Use of <i>N</i>‐Alkyl‐2,2′‐bipyrrolidine Derivatives as Organocatalysts for the Asymmetric Michael Addition of Ketones and Aldehydes to Nitroolefins (2004)

Abstract The direct Michael addition of aldehydes and ketones to nitroolefins, catalyzed by N‐i‐ Pr‐2,2′‐bipyrrolidine, is described. The desired 1,4‐adducts are obtained in excellent yields with enantioselectivities up to 95% ee and dr up to 95 : 5 of the syn aldehyde addition product. An unexpected inversion of diastereoselectivity was observed for the addition of α‐hydroxy ketones to β‐arylnitroolefins with enantioselectivities up to 98% ee. The formation of an internal hydrogen bond between the OH group of the α‐hydroxy ketone and the tertiary nitrogen of the catalyst leads to the formation of a rigid cis enamine intermediate that accounts for the inversion of the expected diastereoselectivity and the very high ees.
Complement fixing activity in diseased human gingival tissues (1981)

Human gingival tissue biopsies were classified as “initial or early” or “established or advanced” periodontal lesions on the basis of the histopathological criteria of Page and Schroeder (1976). They were then examined for the ability to fix complement by the anticomplement immunofluorescence technique which detects fixation of exogenously applied guinea pig complement. Complement fixation was found in association with IgG deposits (detected by immunohistochemical staining) in 80 % of the established and advanced lesion, thus suggesting that it was fixed by immune complexes or aggregated IgG. The complement fixing activity was not associated with IgA or IgM deposits. In contrast, less than 13 % of the initial and early lesions were found to contain such activity. The presence of complement fixing activity was thus found to be significantly correlated with the more advanced as opposed to the earlier stages of periodontal inflammation (p = 0.02 by Chisquare analysis).
Capacity growth of multi-element arrays in indoor and outdoor wireless channels (2002)

We demonstrate the capacity growth of multiple-element antenna arrays (MEAs) in a realistic propagation environment using WiSE, an experimental ray tracing tool. WiSE is used to construct the channel response for MEAs operating at 1.9 GHz for two situations: (a) (16-16)-MEAs located inside an office building and (b) (4, 4)-MEAs located in an outdoor fixed wireless loop. We define effective degrees of freedom (EDOFs) as parallel spatial modes of transmission for an MEA. We quantify the increase in both the number of EDOFs and capacity with transmit power, received SNR, and antenna spacing. More EDOFs are present when receiving MEAs are physically closer to the transmitting MEA, regardless of the scattering effect.
Analytical model in a weakly coupled sandwich for memory purposes (1996)

A simple analytical model explains giant magnetoresistive properties in a weakly coupled sandwich with two magnetic components. The model describes in detail a new storage mechanism in which the minor loop’s slope depends on its past magnetic histories. A new type of solid-state giant magnetoresistance memory based upon this mechanism has been realized by experiments. Furthermore, some important factors included in nondestructive readout capability are also analyzed by this model.
The Self-Incompatibility Genes Of Brassica: Expression And Use In Genetic Ablation Of Floral Tissues (1991)

Crop loss due to soil salinization is an increasing threat to agriculture worldwide. This review provides an overview of cellular and physiological mechanisms in plant responses to salt. We place cellular responses in a time- and tissue-dependent context ...Read More
<title>Multiband sensor system design trade-offs and their effects on remote sensing and exploitation</title> (1997)

This paper describes a study in progress. Its objective is to investigate the effects of spectral and spatial resolution, spectral coverage, signal-to-noise (SNR), and terrestrial background environments on hyperspectral exploitation performance and to determine their tradeoffs. The trade space and the methodologies used to perform nonliteral exploitation functions such as anomaly/target detection, material identification, and abundance estimation are described. Of the three exploitation functions, only summary anomaly/target detection results are presented in this paper. They are presented as a function of 4 spatial resolutions, 4 spectral resolutions, 2 spectral regions, 2 SNR levels, and 2 backgrounds. Anomaly/target detection performance comparison is made in terms of detection success rate when the false alarm rate is held constant for all image cubes. Within the study's trade space,results so far indicate that spatial resolution is the most important parameter for anomaly/target detection, followed by SNR and spectral resolution. Subsequent work on the effects of the same sensor design parameters on material identification is near completion and results will be documented in the very near future.
Emotional Intelligence (1990)

This article presents a framework for emotional intelligence, a set of skills hypothesized to contribute to the accurate appraisal and expression of emotion in oneself and in others, the effective regulation of emotion in self and others, and the use of feelings to motivate, plan, and achieve in one's life. We start by reviewing the debate about the adaptive versus maladaptive qualities of emotion. We then explore the literature on intelligence, and especially social intelligence, to examine the place of emotion in traditional intelligence conceptions. A framework for integrating the research on emotion-related skills is then described. Next, we review the components of emotional intelligence. To conclude the review, the role of emotional intelligence in mental health is discussed and avenues for further investigation are suggested.
Distributed ONS and its Impact on Privacy (2007)

The EPC Network is an industry proposal to build a global information architecture for objects carrying RFID tags with electronic product codes (EPC). A so-called object naming service (ONS) is used to locate information sources for these objects in the EPC Network. But ONS is based on DNS, which suffers from well-studied weaknesses in robustness, configuration complexity and security. There are promising approaches to enhance the performance and robustness of DNS by using structured P2P systems based on distributed hash tables (DHT) that have a high potential as a replacement for ONS as well. We investigate if and how a decentralized alternative to ONS based on DHT could additionally offer data access control and enhance the privacy of its clients. As it turns out, the strength of privacy protection will slightly increase by using DHT compared to DNS, but strong protection will depend on the feasibility of secure out- of-band key distribution mechanisms.
Cluster, SOM and NMF Analyses of Web Patterns (2009)

This paper focuses on web pages clustering as a tool for typical Web patterns searching and using. Traditional methods of cluster analysis, self-organizing map and nonnegative matrix factorization were applied. Web pages on products sale and automatically detected Web patterns were used as a testing data. The application of GD-CLS (gradient descent constrained least squares) which combines some of the best features of other methods was evaluated as the best solution.
A hybrid multilevel control scheme for supporting mixed traffic in broadband networks (1996)

The paper discusses a control scheme for broadband switching systems consisting of a hybrid multilevel control network and a three-phase commit control protocol. The proposed architecture and protocol allow for fast connection setup in point-to-point connections while efficiently handling multicast and broadcast connections. The consistency of system status is maintained through the three-phase commit procedure. The optimal control configuration to minimize the connection setup service time is derived by using both analytical and simulation approaches.
The evolution of sugar isomerases (1995)

L-Arabinose isomerase (EC 5.3.1.4) catalyzes the isomerization of L-arabinose to L-ribulose. Here we report on the purification, kinetic mechanism and chemical mechanism of L-arabinose isomerase from Escherichia coli. The enzyme catalyzes the isomerization of L-arabinose to L-ribulose by a proton transfer mechanism, in contrast to xylose isomerase which uses a hydride transfer mechanism to perform a similar isomerization. Arabinose isomerase activity is metal dependent, although the enzyme can catalyze the exchange of the proton attached to carbon 2 of arabinose with the solvent in the absence of metal ion. Manganese(II) is the only metal ion which renders the enzyme active for the isomerization reaction. Arabinose isomerase has high substrate specificity for L-arabinose. The difference in chemical mechanism between xylose isomerase and arabinose isomerase suggests that these enzymes are not related by convergent evolution. This work also suggests that unless convergent evolution has been demonstrated, the mechanism of one enzyme may not give any insight into the mechanism of a second enzyme catalyzing the same reaction.
Configurable Optical Interconnects for Scalable Datacenters (2013)

High performance interconnects provide communications for large datacenters. Optical interconnects are replacing copper as bandwidth increases. This paper uses small MEMs optical switches to reconfigure large datacenter interconnects for varying needs.
OVERVIEW OF MUCOADHESIVE BIOPOLYMERS FOR BUCCAL DRUG DELIVERY SYSTEMS (2019)

Mucoadhesive dosage forms may be intended for facilitation of prolonged retention time at the application site hence providing drug release in a controlled rate for enhanced improvement of therapeutic activity and its outcome. The buccal mucosa has been investigated for systemic drug delivery and local drug treatment or therapy that is subjected to first pass metabolism. The applicability of bio-adhesion approach in buccal drug delivery proved great therapeutic potential to overcome the limitation of conventional buccal drug delivery. The delivery via buccal route using mucoadhesive biopolymers such as various natural gums e.g. carrageenans, gum karaya, gum arabic, locust bean gum, khaya gum, gum ghatti, albizia gum, guar gum, starch, cellulose, larch gum and pectin etc. and various thiolated and carboxymethylated polymers has been the subject of interest since the early 20th century. The present article is focused mainly on the oral mucosa, mechanism of drug permeation, and characteristics of the desired polymers, the manuscript then proceeds to cover the theories behind the adhesion of bioadhesive polymers to the mucosal epithelium followed by the factors affecting mucoadhesion. Further the author has also discussed on the new generation of mucoadhesive polymers and their properties, recent mucoadhesive formulations for enhanced buccal drug delivery, various marketed products and patent literature. Various online search engines and scientific journals were employed for the collection of literature and scientific data and information related to the topic using keywords like mucoadhesive polymers, buccal drug delivery, buccal patches, tablets, films, gels, powder from the year 2002 and above.
Mitochondrial DNA mutations in complex I and tRNA genes in Parkinson’s disease (2000)

mtDNA mutations with a high mutational burden (present in a high percentage of mtDNA molecules in an individual) in complex I or tRNA genes do not play a major role in the risk of PD in most PD patients. Further investigations are necessary to determine if any of the rare mtDNA mutations identified in PD patients play a role in the pathogenesis of PD in those few cases.
Population Impact of Heart Failure and the Most Common Forms of Cancer (2010)

These data confirm that, like most common forms of cancer combined, HF exerts a major health burden in respect to age-adjusted rates of first hospitalization, poor overall survival, and premature life-years lost.
Dysphagia and aspiration (2012)

Although the right hemisphere is often referred to as the nondominant or minor hemisphere, this chapter delineates its dominant and lateralized contributions to various cognitive and behavioral functions, including language, emotions, facial recognition, nonverbal memory, visuospatial processing, behavioral and delusional syndromes, that are often complementary to the dominant and lateralized functions of the left hemisphere. The presence of persistent hemispatial neglect is associated with poor functional outcome as measured by the ability to live independently. Amnesias with temporally short retrograde deficits have been conceptualized as pure or core amnesias because they are usually not contaminated by other cognitive-behavioral disturbances, such as confabulation or frontal executive dysfunction. Agnosias are considered relatively rare disorders because, traditionally, they were described in patients following discrete bilateral lesions. Most studies have found that motor impersistence is observed more commonly after right- compared to left-sided hemispheric lesions, with many patients having a left hemiparesis.
Novel Methods for the Production of Foamed Polymers. Nucleation of Dissolved Gas by Localized Hot Spots (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNovel Methods for the Production of Foamed Polymers. Nucleation of Dissolved Gas by Localized Hot SpotsR. H. Hansen and W. M. MartinCite this: Ind. Eng. Chem. Prod. Res. Dev. 1964, 3, 2, 137–141Publication Date (Print):June 1, 1964Publication History Published online1 May 2002Published inissue 1 June 1964https://pubs.acs.org/doi/10.1021/i360010a016https://doi.org/10.1021/i360010a016research-articleACS PublicationsRequest reuse permissionsArticle Views128Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Vascular progenitors derived from murine bone marrow stromal cells are regulated by fibroblast growth factor and are avidly recruited by vascularizing tumors (2004)

Bone marrow-derived stromal cells (BMSC) possess a population of vascular progenitor cells that enable them to acquire a histology and immunophenotype coherent with endothelial cells (EC). Recent evidence indicates that a hypoxic environment such as that encountered in tumor masses regulates BMSC angiogenic properties by pathways that remain to be defined. It is also unclear as to what extent these marrow-derived precursor cells could contribute to the growth of endothelium-lined vessels at the vicinity of tumor masses. In this study, we found that BMSC exhibited the ability to generate three-dimensional capillary-like networks on Matrigel, and that this property was up-regulated by growth factors-enriched conditioned media isolated from several tumor-derived cell lines. In particular, basic fibroblast growth factor, a key mediator of angiogenesis, was found to be the most potent growth factor for inducing BMSC proliferation, migration, and tubulogenesis. The setup of a new two-dimensional in vitro co-culture assay further showed that BMSC were massively recruited when cultured in the presence of either cancerous or differentiated EC lines. In vivo, subcutaneous co-injection of BMSC with U-87 glioma cells in nude mice resulted in the formation of highly vascularized tumors, where BMSC differentiated into CD31-positive cells and localized at the lumen of vascular structures. Our data suggest that BMSC could be recruited at the sites of active tumor neovascularization through paracrine regulation of their angiogenic properties. These observations may have crucial implications in the development of novel therapies using BMSC engineered to secrete anti-cancerous agents and to antagonize tumor progression.
Meaningful regions segmentation in CBIR (2005)

In this paper, a new approach to fully automatic image segmentation is proposed to get the meaningful regions of general-purpose image. In order to avoid image over segmenting, the original input image is first smoothed by Gaussian filters with different scales. Then an improved ISODATA clustering algorithm with parameters selecting dynamically is proposed to cluster the image pixels into different regions. To eliminate those fragmentary regions, a region merging strategy is also presented. The final experimental results show that the proposed approach can effectively separate the objects from background of general-purpose image.
Raman spectroscopy of human vitreous in proliferative diabetic retinopathy. (1994)

These findings suggest that human vitreous obtained from subjects with diabetes may be distinguished from control vitreous by FT-RS and that the peaks characterizing the diabetic samples are possibly due to nonenzymatic glycation. Raman spectroscopy may provide a useful method to elucidate the molecular events underlying these abnormalities.
Simultaneous Determination of Aflatoxins, Ochratoxin A, and Zearalenone in Grains by New Immunoaffinity Column/Liquid Chromatography (2004)

The simultaneous determination of mycotoxins was performed in 3 steps: extraction, cleanup, and detection. For extraction, a mixture of acetonitrile-water (60 + 40, v/v) was proved appropriate. For cleanup, a new Afla-Ochra-Zea immunoaffinity column was used. After derivatization with trifluoroacetic acid, the mycotoxins aflatoxins, ochratoxin A (OTA), and zearalenone (ZEA) were determined simultaneously by liquid chromatography with fluorescence detection. The detection limits in different matrixes after cleanup with the new immunoaffinity column were very low: aflatoxins, 0.002-0.7 microg/kg; OTA, 0.07-0.25 microg/kg; ZEA, 1-3 microg/kg. The limits of determination were: aflatoxins, 0.25 microg/kg; OTA, 0.5 microg/kg; ZEA, 5 microg/kg. The recovery rates for aflatoxins, OTA, and ZEA for rye and rice were between 86 and 93% when a 0.5 g sample matter per immunoaffinity column was used.