gebhart/patrepeval huggingface dataset:
Weight-supported treadmill vs over-ground training for walking after acute incomplete SCI (2006)

The physical therapy strategies of body weight support on a treadmill and defined overground mobility therapy did not produce different outcomes. This finding was partly due to the unexpectedly high percentage of American Spinal Injury Association C subjects who achieved functional walking speeds, irrespective of treatment. The results provide new insight into disability after incomplete spinal cord injury and affirm the importance of the multicenter, randomized clinical trial to test rehabilitation strategies.
Invertase-nanogold clusters decorated plant membranes for fluorescence-based sucrose sensor (2015)

In the present study, invertase-mediated nanogold clusters were synthesized on onion membranes, and their application for sucrose biosensor fabrication was investigated. Transmission electron microscopy revealed free nanoparticles of various sizes (diameter ~5 to 50 nm) along with clusters of nanogold (~95 to 200 nm) on the surface of inner epidermal membranes of onions (Allium cepa L.). Most of the polydispersed nanoparticles were spherical, although some were square shaped, triangular, hexagonal or rod-shaped. Ultraviolet-visible spectrophotometric observations showed the characteristic peak for nanoparticles decorated invertase-onion membrane at approximately 301 nm. When excited at 320 nm in the presence of sucrose, the membranes exhibited a photoemission peak at 348 nm. The fluorescence lifetime of this nanogold modified onion membrane was 6.20 ns, compared to 2.47 ns for invertase-onion membrane without nanogold. Therefore, a sucrose detection scheme comprised of an invertase/nanogold decorated onion membrane was successfully developed. This fluorescent nanogold-embedded onion membrane drop-test sensor exhibited wide acidic to neutral working pH range (4.0-7.0) with a response time 30 seconds (<1 min). The fabricated quenching-based probe had a low detection limit (2x10(-9) M) with a linear dynamic range of 2.25x10(-9) to 4.25x10(-8) M for sensing sucrose. A microplate designed with an enzyme-nanomaterial-based sensor platform exhibited a high compliance, with acceptable percentage error for the detection of sucrose in green tea samples in comparison to a traditional method. With some further, modifications, this fabricated enzyme-nanogold onion membrane sensor probe could be used to estimate glucose concentrations for a variety of analytical samples. Graphical abstract Synthesis and characterization of invertase assisted nanogold clusters on onion membranes and their application for fluorescence-based sucrose sensor.
Structure of the feline c-fes/fps proto-oncogene: genesis of a retroviral oncogene (1987)

The nucleotide sequence of the feline c-fes/fps proto-oncogene was analyzed. Comparison with v-fes and v-fps revealed that all v-fes/fps homologous sequences were dispersed over 11 kilobase pairs in 19 interspersed segments. All segments, numbered exon 1 to exon 19 as in the chicken and human loci, were flanked by consensus splice junctions. The putative promoter region contained a CATT sequence and three CCGCCC motifs which were also found in the human locus at similar positions. About 200 nucleotides downstream of a translational stop codon in exon 19, a putative poly(A) addition signal was identified. Using the putative translation initiation codon in exon 2, a 93,000-molecular-weight protein could be deduced. This protein resembled very well the putative protein of the human c-fes/fps proto-oncogene (94% overall homology) and, although less well, the putative protein of the chicken c-fes/fps proto-oncogene (70% overall homology). As far as the feline c-fes/fps proto-oncogene sequences transduced to the Gardner-Arnstein (GA) and Snyder-Theilen (ST) strains of feline sarcoma virus (FeSV) are concerned, homology in deduced amino acid sequences between the GA- and ST-v-fes viral oncogenes and the proto-oncogene was 99%. Analysis of the recombination junctions between feline leukemia virus and v-fes sequences in GA- and ST-FeSV proviral DNA revealed for the left-hand junction the involvement of homologous recombination, presumably at the DNA level. The right-hand junction, which appeared identical in the GA-FeSV and ST-FeSV genomes, could have been the result of a site-specific recombination at the RNA level.
A novel fast motion estimation algorithm using fixed subsampling pattern and multiple local winners search (2002)

In this paper, a novel fast algorithm for block motion estimation is proposed. The reduction of computation complexity is obtained from the use of pixel sub-sampling on block matching instead of limiting the number of searching locations. Further, in order to get the better quality, this algorithm uses a technique of multiple local winners. From the experimental result, the proposed algorithm produces better performance than some other fast block-matching algorithms like three-step search (TSS), four-step search (FSS), new three-step search (NTSS), new diamond search (DS), hybrid search (HBS) and four-step genetic algorithm (4GA). That is, the performance of proposed algorithm not only reduces the computational time but also improves the accuracy of motion vectors.
Grundlagen der Schriftsprache (1994)

Sokrates war kein „homme de lettre“. Trotzdem markiert sein Denken den Beginn der abendländischen literalen Kultur, für deren Entwicklung keine Erfindung so bedeutsam war, wie die der Schriftsprache. Seit Platon und in verstärktem Maße seit Gutenberg ist das Buch einer der wichtigsten Träger der Kultur und unverzichtbar für die kulturelle Überlieferung.
Specifying Flexible Charging Rules for Composable Services (2008)

Where services are offered on a commercial basis, the manner in which charges for service usage are calculated is of key importance. Services typically have associated with them a charging scheme specifying the rules for charge calculation; schemes can range from the simple (such fixed charge per service invocation) to highly complex (where charges are calculated dynamically in order to influence customer demand and thereby optimise overall system performance). Typically, charging schemes are manually configured and verified prior to services being made available to customers - typically, a time consuming and expensive process. In environments where service compositions can be rapidly built and offered to customers, manual specification of a charging scheme for the service composition becomes untenable. In this paper we describe how charge modification rules associated with individual services can be used to flexibly govern how a service is charged for when it is used in the context of a composed service.
District cooling: Phase 2, Direct freeze ice slurry system testing (1991)

The objectives of this research are to: extend the range of pressure drop data for ice-water slurry flows, and design and build a prototypical ice slurry distribution system which demonstrates ice slurry handling at an end user's heat exchanger, without sending ice slurry directly through the heat exchanger. The results of Phase 1 work demonstrated a 40% reduction in pump power required to move an ice-water slurry versus the same mass flow of water only. In addition to lower pressure drop, pumping ice slurries is advantageous because of the large latent and sensible heat cooling capacity stored in the ice compared to only sensible heat in chilled water. For example, an ice-water slurry with a 20% ice fraction (by mass) has a mass flow rate that is 70% less than the mass flow rate required for a chilled water system cooling and equivalent load. The greatly reduced mass flow combined with the friction reducing effects of ice-water slurries results in a total savings of 83% in pumping power. Therefore, a substantial savings potential exists for capital costs and system operating costs in ice-water slurry district cooling systems. One potential disadvantage of an ice-slurry district cooling system is the introduction of ice into equipment not so designed, such as air handlers at end user locations. A prototypic ice slurry distribution loop will demonstrate a cooling network which will provide ice slurry to an end user but sends ice free water into the actual heat transfer.
Lexicons on Demand: Neural Word Embeddings for Large-Scale Text Analysis (2017)

Human language is colored by a broad range of topics, but existing text analysis tools only focus on a small number of them. We present Empath, a tool that can generate and validate new lexical categories on demand from a small set of seed terms (like "bleed" and "punch" to generate the category violence). Empath draws connotations between words and phrases by learning a neural embedding across billions of words on the web. Given a small set of seed words that characterize a category, Empath uses its neural embedding to discover new related terms, then validates the category with a crowd-powered filter. Empath also analyzes text across 200 built-in, pre-validated categories we have generated such as neglect, government, and social media. We show that Empath's data-driven, human validated categories are highly correlated (r=0.906) with similar categories in LIWC.
Seven layers of knowledge representation and reasoning in support of software development (1992)

The authors' experience in the Programmer's Apprentice project in applying knowledge representation and automated reasoning to support software development is summarized. A system, called Cake, is described that comprises seven layers of knowledge representation and reasoning facilities: truth maintenance, Boolean constraint propagation, equality, types, algebra, frames, and Plan Calculus. Sessions with two experimental software development tools implemented using Cake, the Requirements Apprentice and the Debugging Assistant, are also included.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Determination of rare earth elements in human blood serum by inductively coupled plasma mass spectrometry after chelating resin preconcentration (2000)

The determination of all rare earth elements (REEs) in human blood serum by inductively coupled plasma mass spectrometry (ICP-MS) was performed with the aid of chelating resin (Chelex 100) preconcentration after acid digestion with HNO3 and HClO4. When chelating resin preconcentration was carried out at room temperature, the recoveries of heavy REEs were lower than those of light REEs because of their stable complex formation with residual organic compounds remaining in the digested serum solution. These problems were overcome by heating the solution at 80 degrees C during the chelating resin preconcentration process. As a result, the recoveries for all REEs were improved to 92-102% in the case of a concentration factor of 4, where the analytical detection limits for REEs were below 0.2 x 10(-12) g ml-1. Consequently, all REEs in individual human blood sera collected from five healthy volunteers could be determined by ICP-MS with good precision. The concentrations of REEs in human blood serum were extremely low, in the range from ca. 1 x 10(-12) g ml-1 of Eu to ca. 230 x 10(-12) g ml-1 of Ce.
Collision avoidance control among moving obstacles for a mobile robot on the fuzzy reasoning. (1988)

本論文ではファジィ推論およびプロダクションルールを適用した移動ロボットの障害物回避方式を提案する.本方式の第1ステップでは, ファジィ推論によりロボットと障害物との間の静的および動的危険度を認識する.第2ステップでは, この危険度を用いてディシジョンテーブルで回避方向を決定する.この方式を用いると動的障害物に対するヒューリスティック回避を実現できる.ここでは, 本方式の有効性を検証したシミュレーション結果について報告する.
Utilization of Mucus from the Coral <i>Acropora palmata</i> by the Pathogen <i>Serratia marcescens</i> and by Environmental and Coral Commensal Bacteria (2009)

In recent years, diseases of corals caused by opportunistic pathogens have become widespread. How opportunistic pathogens establish on coral surfaces, interact with native microbiota, and cause disease is not yet clear. This study compared the utilization of coral mucus by coral-associated commensal bacteria ("Photobacterium mandapamensis" and Halomonas meridiana) and by opportunistic Serratia marcescens pathogens. S. marcescens PDL100 (a pathogen associated with white pox disease of Acroporid corals) grew to higher population densities on components of mucus from the host coral. In an in vitro coculture on mucus from Acropora palmata, S. marcescens PDL100 isolates outgrew coral isolates. The white pox pathogen did not differ from other bacteria in growth on mucus from a nonhost coral, Montastraea faveolata. The ability of S. marcescens to cause disease in acroporid corals may be due, at least in part, to the ability of strain PDL100 to build to higher population numbers within the mucus surface layer of its acroporid host. During growth on mucus from A. palmata, similar glycosidase activities were present in coral commensal bacteria, in S. marcescens PDL100, and in environmental and human isolates of S. marcescens. The temporal regulation of these activities during growth on mucus, however, was distinct in the isolates. During early stages of growth on mucus, enzymatic activities in S. marcescens PDL100 were most similar to those in coral commensals. After overnight incubation on mucus, enzymatic activities in a white pox pathogen were most similar to those in pathogenic Serratia strains isolated from human mucosal surfaces.
Effects of clodronate on synovial fluid levels of some inflammatory mediators, after intra-articular administration to patients with synovitis secondary to knee osteoarthritis. (2001)

Recent studies have outlined the role of bisphosphonates, and particularly clodronate, as potential therapeutic agents for inflammatory and degenerative joint diseases. On this basis, we carried out an open, non comparative pilot trial to evaluate the effects of clodronate on synovial fluid concentration of some inflammatory mediators (prostaglandin E2, leukotriene B4 and tromboxane B2) after intra-articular, repeated administrations in 20 patients (7 males and 13 females) with synovitis secondary to knee osteoarthritis. At the end of the treatment period, statistically significant reductions (p < 0.05) of spontaneous pain and pain on active movement, evaluated by means of a 100 mm visual analogue scale (VAS), were reported. Linear regression analysis showed that the decrease of pain was correlated with the bisphosphonate induced reduction of prostaglandin E2 levels. These results, in spite of the limitation due to the open design of the trial suggest a possible role of bisphosphonates in the treatment of knee osteoarthritis.
IMMUNOSUPPRESSION OF GRAFT REJECTION WITH IDARUBICIN-MONOCLONAL ANTIBODY CONJUGATES BY ELIMINATION OF T CELL SUBSETS IN VIVO (1988)

Idarubicin, a more therapeutically effective derivative of daunomycin, when coupled to monoclonal antibodies that react with murine and human tumors has the ability to specifically target and eradicate tumor cell populations in vitro and in vivo. In this study the in vitro and in vivo efficacy of idarubicin coupled to monoclonal antibodies reactive with distinct subpopulations of lymphocytes (L3T4+, Ly-2+) has been characterized. Using a tumor allograft model in vivo the potential use of drug-monoclonal antibody conjugates to prevent graft rejection has been investigated. Three to five molecules of Idarubicin could be coupled to the monoclonal antibodies (anti-Ly-2.1, anti-L3T4, or anti-Thy-1) with retention of protein solubility and antibody activity. Some loss of idarubicin activity (4-10-fold) occurred upon conjugation to the monoclonal antibodies--however, selective cytotoxicity for antibody reactive cell lines was observed. All three conjugates demonstrated the capacity to significantly deplete reactive subsets of spleen cells--further evidenced by the ability of combined idarubicin-anti-L3T4 and Idarubicin-anti-Ly-2.1 treatment of idarubicin-anti-Thy-1 treatment to prolong the survival of (Ly-2-, L3T4-) P388D1 tumor grafts in CBA mice in the presence of H-2 and non H-2 antigenic differences. This form of selective immunosuppression may have relevance for the treatment of graft rejection in man.
Dynamics of capping protein and actin assembly in vitro: uncapping barbed ends by polyphosphoinositides. (1996)

Bursts of actin polymerization in vivo involve the transient appearance of free barbed ends. To determine how rapidly barbed ends might appear and how long they might remain free in vivo, we studied the kinetics of capping protein, the major barbed end capper, binding to barbed ends in vitro. First, the off-rate constant for capping protein leaving a barbed end is slow, predicting a half-life for a capped barbed end of approximately 30 min. This half-life implies that cells cannot wait for capping protein to spontaneously dissociate from capped barbed ends in order to create free barbed ends. However, we find that phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidylinositol 4-mono-phosphate (PIP) cause rapid and efficient dissociation of capping protein from capped filaments. PIP2 is a strong candidate for a second messenger regulating actin polymerization; therefore, the ability of PIP2 to remove capping protein from barbed ends is a potential mechanism for stimulating actin polymerization in vivo. Second, the on-rate constant for capping protein binding to free barbed ends predicts that actin filaments could grow to the length of filaments observed in vivo during one lifetime. Third, capping protein beta-subunit isoforms did not differ in their actin binding properties, even in tests with different actin isoforms. A major hypothesis for why capping protein beta-subunit isoforms exist is thereby excluded. Fourth, the proposed capping protein regulators, Hsc70 and S100, had no effect on capping protein binding to actin in vitro.
Blinatumomab: a CD19/CD3 bispecific T cell engager (BiTE) with unique anti-tumor efficacy (2016)

Blinatumomab is a member of a novel class of T cell-engaging bispecific antibodies, so-called Bispecific T cell Engager (BiTEs). It is directed against the B cell differentiation antigen CD19 and intended for treatment of B cell malignancies. In clinical phase I/II trials, blinatumomab showed remarkable single-agent activity in patients with relapsed and/or refractory (R/R) non-Hodgkin lymphoma and R/R B cell precursor acute lymphoblastic leukemia (B-precursor ALL). Cytokine release syndrome and neurological side effects were dose-limiting. Adverse effects were well manageable and transient in nature. Based on results of an international phase II trial, blinatumomab received FDA approval for the treatment of R/R B-precursor ALL in December 2014. Ongoing and future trials will contribute to further optimization of blinatumomab-based T cell therapy and have to show that integration of blinatumomab in current and innovative treatment protocols improves overall survival and quality of life of patients with B cell malignancies.
Zur Berechnung der 2-Klassenzahl der quadratischen Zahlkörper mit genau zwei verschiedenen Diskrimantenprimteilern. (1971)

Article Zur Berechnung der 2-Klassenzahl der quadratischen Zahlkörper mit genau zwei verschiedenen Diskrimantenprimteilern. was published on January 1, 1971 in the journal Journal für die reine und angewandte Mathematik (volume 1971, issue 248).
Zone Based Systems Design Framework for the Realisation of Efficient Block Cipher Based Message Authentication Code Algorithms (2010)

A zone based systems design framework is described and utilized in the implementation of a message authentication code (MAC) algorithm based on symmetric key block ciphers. The resulting block cipher based MAC algorithm may be used to provide assurance of the authenticity and, hence, the integrity of binary data. Using software simulation to benchmark against the de facto cipher block chaining MAC(CBC-MAC) variant used in the TinySec security protocol for wireless sensor networks and the NIST cipher block chaining MAC standard, CMAC; we show that our zone based systems design framework can lead to block cipher based MAC constructs that point to improvements in message processing efficiency, processing throughput and processing latency.
The Effect of the Physiological Environment on the Mechanical Properties of Biomaterials in Cardiovascular Applications (1978)

The long-term biocompatibility and physical performance of polymeric materials in the physiological environment depend both on adsorption and absorption processes. While the former has received significant attention in the literature, the latter has not been sufficiently appreciated. Accelerated testing of prosthetic devices in the wrong media and temperatures yield misleading information as exemplified by pumping bladders of heart assist devices and heart valves. Although glutaraldehyde-treated porcine heterograft heart valves performed better than expected in humans over a period of several years, physical degradations that have been observed may be associated with the breakdown of the cross-links. Appropriately selected smooth-surfaced biomaterials and hydrogels are far better suited for temporary blood contacting prosthetic applications such as left ventricular heart assist devices (LVADs) than polyester flocked fibril surfaces that result in the deposition of a thick layer of fibrin/cellular mesh with clot-like morphology with inherent dangers of loss of polyester fibrils, and the shedding of clots as the result of cyclic flexing of the pump bladders. With the proliferation of various medical devices, the possibility of increased litigations with secondary and tertiary liabilities involving not only physicians, surgeons, and device manufacturers, but also suppliers of materials and components, it is essential to select pertinent rather than complex test procedures.
Dielectric properties of trypsin inhibitor and lysozyme calculated from molecular dynamics simulations (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDielectric properties of trypsin inhibitor and lysozyme calculated from molecular dynamics simulationsPaul E. Smith, Roger M. Brunne, Alan E. Mark, and Wilfred F. Van GunsterenCite this: J. Phys. Chem. 1993, 97, 9, 2009–2014Publication Date (Print):March 1, 1993Publication History Published online1 May 2002Published inissue 1 March 1993https://pubs.acs.org/doi/10.1021/j100111a046https://doi.org/10.1021/j100111a046research-articleACS PublicationsRequest reuse permissionsArticle Views769Altmetric-Citations155LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts