gebhart/patrepeval huggingface dataset:
HMGB1 Binds to Lipoteichoic Acid and Enhances TNF-a and IL-6 Production through HMGB1-Mediated Transfer of Lipoteichoic Acid to CD14 and TLR2 (2015)

Lipoteichoic acid (LTA) is a component of the cell wall of Gram-positive bacteria and induces a toll-like receptor 2 (TLR2)-mediated inflammatory response upon initial binding to lipopolysaccharide-binding protein (LBP) and subsequent transfer to CD14. In this study, we identified a novel role for the nuclear protein high-mobility group box 1 (HMGB1) in LTA-mediated inflammation. Results of ELISA, surface plasmon resonance and native PAGE electrophoretic mobility shift analyses indicated that HMGB1 binds to LTA in a concentration-dependent manner and that this binding is inhibited by LBP. Native PAGE, fluorescence-based transfer and confocal imaging analyses indicated that HMGB1 catalytically disaggregates LTA and transfers LTA to CD14. NF-κB p65 nuclear transmigration, degradation of IκBα and reporter assay results demonstrated that NF-κB activity in HEK293-hTLR2/6 cells is significantly upregulated by a mixture of LTA and soluble CD14 in the presence of HMGB1. Furthermore, the production of TNF-α and IL-6 in J774A.1 and RAW264.7 cells increased significantly following treatment with a mixture of LTA and HMGB1 compared with treatment with LTA or HMGB1 alone. Thus, we propose that HMGB1 plays an important role in LTA-mediated inflammation by binding to and transferring LTA to CD14, which is subsequently transferred to TLR2 to induce an inflammatory response.
Transcription unit of the rabbit beta 1 globin gene. (1985)

We have hybridized pulse-labeled nuclear transcripts to cloned DNA fragments from the rabbit beta-like globin genes to determine the developmental timing, extent, and asymmetry of their transcription. The fetal-adult gene beta 1 was transcribed in fetal liver but not embryonic nuclei, whereas genes beta 3 and beta 4, which encode embryonic globin polypeptides, were transcribed only in embryonic nuclei. This shows that the switch from embryonic to fetal-adult globin production in rabbits is accomplished primarily by differential transcription of the beta-like globin genes. Gene beta 1 was subdivided into M13 subclones and tested for hybridization to nascent RNA. The nucleotide sequence of the 3' flanking region of gene beta 1 was also determined for 2,447 base pairs past the polyadenylation [poly(A)] site. No transcripts were found 5' to the cap site, but asymmetric transcription of gene beta 1 proceeded at a high level through the gene and past the poly(A) addition site for 603 nucleotides. The level of transcription declined after this, gradually dropping through the next 568 nucleotides. No polymerases were found on a fragment that begins 1,707 nucleotides past the poly(A) site; this fragment was part of a segment of repetitive DNA. These data show that the transcription unit of gene beta 1 begins at or near the cap nucleotide and extends at least 1,171 but no more than 1,706 nucleotides past the poly(A) addition site. The DNA segment that precedes the region of declining transcription contained an inverted repeat and encoded a short RNA transcribed by RNA polymerase II from the strand opposite the beta 1 transcript. These two features may function to attenuate the transcription of gene beta 1. An inverted repeat and a potential polymerase II transcription unit were also found in the homologous segment 3' to the human beta-globin gene. A short DNA segment close to the 3' end of the beta 1 transcription unit was transcribed more actively than the surrounding DNA, and it contained sequences that match the consensus internal control region for RNA polymerase III. This DNA segment may contain a separate polymerase III transcription unit. A member of the D repeat family located 3' to gene beta 1 was not transcribed in its entirety coordinately with beta 1.
Visible light induced ring-opening metathesis polymerisation of cyclooctene (2001)

Under visible light irradiation, ruthenium–arene complexes bearing N-heterocyclic carbene ligands with aryl substituents – either preformed or generated in situ – are active catalyst precursors for the ROMP of cyclooctene already at room temperature.
Applying Multi-level Sliced Speech Signals to Bone-conducted Communication (2005)

In this paper, wave-shaping is produced by a circuit using a comparator, and the relation between the slice level of the speech waveform and the articulation when varying the slice level after some steps is described. The wave-shaped speech wave described above is called a multi-level sliced speech signal (a 3-level sliced or 5-level sliced speech signal).
Content-based publish/subscribe networking and information-centric networking (2011)

On-line information comes in different forms and is accessed in different ways and for different purposes. For example, a recording of Beethoven's Ninth Symphony differs from a storm warning from the local weather service. Beethoven's Ninth is a large media file with perpetual validity that is typically accessed on demand by users. By contrast, a storm warning is a small ephemeral message typically pushed by the weather service to all users in a specific geographic area. We argue that both should and would be well supported by an information-centric network. More specifically we argue three points. First, modern applications, reflecting the nature of human communications, use and transmit large and long-lived files as well as small ephemeral messages. Second, accessing those two types of information involves significantly different operations within the network. Third, despite their differences, both types of information would benefit from an addressing scheme based on content rather than on more or less flat identifiers, which means that both should be integrated to some extent within a unified content-based routing infrastructure.
Digital Computer Aids for the Cardiac Output Calculation from Radio Isotope Dilution Curves (1962)

Electronic digital computer was applied on the analysis of radioisotope dilution curve, and 6 parameters including exponent k, integrated area under the dilution curve (S), cardiac output, mean circulation time, central blood volume and pulmonary blood volume (Newman) were calculated automatically at high speed. Using this method, detailed analysis was performed in 14 cases. To obtain well correlated values with the conventional ones, 3 different procedures of computer program were examined and relatively good results were obtained by procedure 3.Advantages of this method, high speed of the automatical calculation and relatively good accuracy, were discussed.
Enhanced upconversion of NaYF_4:Er^3+/Yb^3+ phosphors prepared via the rapid microwave-assisted hydrothermal route at low temperature: phase and morphology control (2016)

Monophasic NaYF4:Er(3+)/Yb(3+) crystals were synthesized via the microwave-assisted hydrothermal route at 180°C. Microwave heating during the hydrothermal process substantially reduces the duration of reaction for the formation of cubic-NaYF4:Er(3+)/Yb(3+) nanocrystals from 6 h to 30 min. As the duration of the reaction increases, cubic-NaYF4:Er(3+)/Yb(3+) nanocrystals are transformed to uniform hexagonal-NaYF4:Er(3+)/Yb(3+) microprisms because of the enhanced reaction kinetics. Bright upconverted emission from the NaYF4:Er(3+)/Yb(3+) crystal, obtained by the efficient two-photon excitation, is related to crystal structure and morphology. The hexagonal microprisms exhibit better upconversion and are employed in security applications.
Novel Integration of Administrative Pharmacy Residents in a Management Course (2021)

Administrative pharmacy residents were successfully integrated into a pharmacy management course redesign, resulting in improved student perceptions of course relevance.
Clinical observation on treatment of 83 cases of posthemiplegic omalgia. (1998)

An analysis on 83 cases of posthemiplegic omalgia (shoulder pain) shows that the pathogenesis of the pain is closely related to the improper passive movement at the early stage of hemiplegia (62.7%). The large range of passive movement is a dangerous factor leading to omalgia. In the study of upper extremity complications, the incidence of shoulder-hand syndrome is relatively high (42.2%), and it is often accompanied by hand swelling (83.1%). The authors suggest that painless movement of the shoulder joint should be limited in a range of 90-120 degrees, massage be carried out immediately after acupuncture, and the affected upper extremity be moved passively during the needle retention. This therapeutic method is definitely effective for pasthemiplegic omalgia.
Micelle to vesicle transition in aqueous solutions of bile salt and lecithin (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMicelle to vesicle transition in aqueous solutions of bile salt and lecithinP. Schurtenberger, N. Mazer, and W. KaenzigCite this: J. Phys. Chem. 1985, 89, 6, 1042–1049Publication Date (Print):March 1, 1985Publication History Published online1 May 2002Published inissue 1 March 1985https://pubs.acs.org/doi/10.1021/j100252a031https://doi.org/10.1021/j100252a031research-articleACS PublicationsRequest reuse permissionsArticle Views992Altmetric-Citations282LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Scanning for Viruses on Encrypted Cloud Storage (2016)

Despite the promise of scalability, efficiency and low cost, the rapid adoption of cloud computing also raises many concerns. In particular, security and privacy has been at the forefront of discussions and research in recent years. In this paper, we consider the unexplored problem of malware detection on encrypted cloud storage, especially relevant when cloud storage facilities are used for data archiving and back up. We noted disadvantages of the current approach to malware detection in anti-virus software, such as the frequent software updates and the threat of reverse engineering as highlighted by recent allegations of a potential sabotage by a industry partner. To address these issues, we propose solutions for performing malware detection in the following scenarios: A private malware scanner for encrypted cloud storage accessed solely by the data owner, an anti-virus as a service provider operating over encrypted cloud data, and an anti-virus service provider operating over unencrypted cloud services. Our private malware scanning solution is based on encrypted indexes and achieves performance comparable to leading keyword search algorithms. Our scheme for anti-virus as a service, based on homomorphic encryption, protects against malicious agents by performing a portion of the detection algorithm on an anti-virus server. The scheme also protects user privacy, having its entire scanning process performed in the encrypted domain. We also include a discussion on the merit of implementing anti-virus as a service on unencrypted data.
X-Ray Structural Study of Terguride SolvatesTerguride Methanol Solvate (1994)

The structure of the unstable solvate of the semisynthetic ergot derivate terguride methanol solvate C 20 H 28 N 4 O .CH 3 OH, was solved by direct methods and refined to an R value of 0.093 for 1 462 unique observed reflections. The title alkaloid crystallizes in the orthorhombic space group P2 1 2 1 2 1 with lattice parameters a = 10.438(1), b = 13.200(4), c = 15.495(5) Å, V = 2 134.8(9) Å 3 , Z = 4. An indole moiety of the terguride molecule is almost perfect planar, ring C has an E 6 envelope conformation and ring D adopts a 1 C 4 chair shape. As found from X-ray powder diffraction study, terguride methanol solvate completely transforms to terguride monohydrate in air during several hours.
Multi-stage spectral subtraction for enhancement of audio signals (2004)

This paper describes a technique based on spectral subtraction (SS) for enhancing audio signals which have nonstationary properties. In the technique, audio signals are modeled as a sum of sinusoidal components, which are called tones, of various frequencies and durations. We show that the analysis window length for SS should be adjusted in accordance with the tone duration to obtain higher performance on SS. Then we propose a multi-stage SS approach into which an appropriate window length selection mechanism is incorporated. We also propose a technique for suppressing an artifact called pre-echo which appears in the noise reduction process. It is shown from the result of a subjective evaluation test that the proposed technique gives superior performance to the conventional SS for enhancement of audio signals including speech, piano, drums, and orchestra.
The Synthesis of a Diastereoisomer of Methyl Acarviosin (1998)

In model studies, a fully protected D-galactopyranoside 4-triflate and two 6-deoxy analogues were shown to alkylate cyclohexylamine, leading to 4-cyclohexylamino-4-deoxy- and 4,6-dideoxy-D-glucopyranosides as the major products in satisfactory yield, accompanied by alkenes resulting from elimination of triflic acid. Coupling of tetra- O -benzyl-1-epivalienamine with methyl 3- O -benzoyl-6-deoxy-4- O - trifluoromethylsulfonyl-ß-D-galactoside gave a diastereoisomer of methyl acarviosin in protected form. Deprotection completed the first synthesis of methyl 4,6-dideoxy-4-[(1' R ,4' R ,5' S ,6' S )-4',5',6'-trihydroxy-3'-(hydroxymethyl)cyclohex-2'-enyl]amino-ß-D-glucoside, a potential ß-glycosidase inhibitor.
Construction of multi‐layered cardiomyocyte sheets using magnetite nanoparticles and magnetic force (2006)

Heart tissue engineering requires construction of three-dimensional (3-D) tissues composed of cardiomyocytes (CMs) that are tightly connected to each other. The aim of this study was to construct "scaffold-less" multi-layered 3-D CM sheets using magnetic force-based tissue engineering (Mag-TE) and to evaluate the cell-to-cell functional connections within the CM sheets. Original magnetite cationic liposomes (MCLs) with a positive surface charge (which facilitate adsorption to the target cell surface) were taken up by CMs that were isolated from 2-day-old Wistar rats. When MCLs were added to the medium of CMs at magnetite concentrations of 25, 50, and 100 pg per cell, subsequent measurements showed that 7.2, 13.2, and 27.3 pg of magnetite were taken up per cell, respectively, after 4 h incubation at 37 degrees C. Further, no toxicity was observed after a 24 h incubation period. Using magnetically labeled CMs (magnetite concentration, 100 pg/cell), multi-layered CM sheets were constructed. Immunofluorescent staining of connexin43 demonstrated the presence of gap junctions within the CM sheets that were constructed by Mag-TE. Moreover, electrical connections within the CM sheets constructed by Mag-TE were confirmed using extracellular potential mapping. These results indicate that Mag-TE is a viable methodology for heart tissue engineering.
Generative Class-conditional Autoencoders (2014)

Recent work by Bengio et al. (2013) proposes a sampling procedure for denoising autoencoders which involves learning the transition operator of a Markov chain. The transition operator is typically unimodal, which limits its capacity to model complex data. In order to perform efficient sampling from conditional distributions, we extend this work, both theoretically and algorithmically, to gated autoencoders (Memisevic, 2013), The proposed model is able to generate convincing class-conditional samples when trained on both the MNIST and TFD datasets.
Integration site-dependent expression of a transgene reveals specialized features of cells associated with neuromuscular junctions. (1991)

After skeletal muscle is denervated, fibroblasts near neuromuscular junctions proliferate more than fibroblasts distant from synaptic sites, and they accumulate adhesive molecules such as tenascin (Gatchalian, C. L., M. Schachner, and J. R. Sanes. 1989. J. Cell Biol. 108:1873-1890). This response could reflect signals that arise perisynaptically after denervation, preexisting differences between perisynaptic and extrasynaptic fibroblasts, or both. Here, we describe a line of transgenic mice in which patterns of transgene expression provide direct evidence for differences between perisynaptic and extrasynaptic fibroblasts in normal muscle. Transgenic mice were generated using regulatory elements from a major histocompatibility complex (MHC) class I gene linked to the Escherichia coli beta-galactosidase (lacZ) gene. Expression of lacZ was detected histochemically. In each of eight lines, lacZ was detected in different subsets of cells, none of which included lymphocytes. In contrast, endogenous MHC is expressed in most tissues and at high levels in lymphocytes. Thus, the MHC gene sequences appeared inactive in the transgene, and lacZ expression was apparently controlled by genomic regulatory elements that were specific for the insertion site. In one line, cells close to the neuromuscular junction were lacZ positive in embryonic and young postnatal mice. Electron microscopy identified these cells as fibroblasts and Schwann cells associated with motor nerve terminals, as well as endoneurial fibroblasts, perineurial cells, and Schwann cells in the distal branches of motor nerves. No intramuscular cells greater than 200 microns from synaptic sites were lacZ positive. These results indicate that there are molecular differences between perisynaptic and extrasynaptic fibroblasts even in normal muscle and that diverse perisynaptic cell types share a specific pattern of gene expression.
Experimental verification of the key properties of a three-dimensional isotropic transmission-line superlens (2006)

Design and experimental realization of a three-dimensional superlens based on inductively and capacitively loaded transmission lines are presented. Transmission properties of the designed structure are studied experimentally and the observed lens properties are compared with analytical predictions. Backward-wave propagation and amplification of evanescent waves in the prototype structure are verified both analytically and experimentally. Commercially available components and materials are used in the design.
Characterization of SB‐271046: A potent, selective and orally active 5‐HT<sub>6</sub> receptor antagonist (2000)

SB-271046, potently displaced [(3)H]-LSD and [(125)I]-SB-258585 from human 5-HT(6) receptors recombinantly expressed in HeLa cells in vitro (pK(i) 8.92 and 9.09 respectively). SB-271046 also displaced [(125)I]-SB-258585 from human caudate putamen and rat and pig striatum membranes (pK(i) 8.81, 9.02 and 8.55 respectively). SB-271046 was over 200 fold selective for the 5-HT(6) receptor vs. 55 other receptors, binding sites and ion channels. In functional studies on human 5-HT(6) receptors SB-271046 competitively antagonized 5-HT-induced stimulation of adenylyl cyclase activity with a pA(2) of 8.71. SB-271046 produced an increase in seizure threshold over a wide-dose range in the rat maximal electroshock seizure threshold (MEST) test, with a minimum effective dose of < or =0.1 mg kg(-1) p.o. and maximum effect at 4 h post-dose. The level of anticonvulsant activity achieved correlated well with the blood concentrations of SB-271046 (EC(50) of 0.16 microM) and brain concentrations of 0.01-0.04 microM at C(max). These data, together with the observed anticonvulsant activity of other selective 5-HT(6) receptor antagonists, SB-258510 (10 mg kg(-1), 2-6 h pre-test) and Ro 04-6790 (1-30 mg kg(-1), 1 h pre-test), in the rat MEST test, suggest that the anticonvulsant properties of SB-271046 are likely to be mediated by 5-HT(6) receptors. Overall, these studies demonstrate that SB-271046 is a potent and selective 5-HT(6) receptor antagonist and is orally active in the rat MEST test. SB-271046 represents a valuable tool for evaluating the in vivo central function of 5-HT(6) receptors.
Et udsyn til billedbøger (2012)

Billedbøger. En grundbog tilbyder en grundviden og et overblik til hjælp for alle, der arbejder med eller vil vide mere om billedbøger. Den præsenterer et udsyn på billedbøger, inddrager aktuelle og historiske tendenser samt banebrydende værker i den danske billedbogs historie og giver hovedtræk i den skandinaviske forskning i billedbøger. Den ser også på billedbogens komplekse udtryk, analyse af billedbøger, tosprogede børn og billedbøger samt rummer en række didaktisk vinklede læsninger af billedbøger. Hensigten med Billedbøger. En grundbog er at bidrage med inspiration til og kvalificering af inddragelsen af billedbøger i undervisningsmæssig sammenhæng. Bogen henvender sig til lærerstuderende, undervisere på læreruddannelsen, dansklærere, skolebibliotekarer og alle andre, der interesserer sig for billedbøger.
Composition of neutral lipids from erythrocytes of common mammals (1967)

The neutral lipids of the erythrocytes were investigated in several common mammals: cow, dog, goat, horse, pig, rabbit, rat, and sheep. Cholesterol content was determined by gas-liquid, thin-layer, and column chromatography, the last in conjunction with the IR spectrophotometry. The three methods yielded similar results. In every species investigated, cholesterol was the major neutral lipid; cholesteryl esters, triglycerides, and free fatty acids were detected only in trace amounts. It is concluded that these substances may have been contaminants from plasma lipoproteins or leukocytes rather than true constituents of the erythrocyte. In the erythrocytes of all species, cholesterol content was close to 30% of the total lipids extracted from the cells, and the molar ratio of cholesterol to phospholipid was approximately one. The significance of the data is discussed in relation to current concepts of the structure of the cell membrane involving cholesterol-polar lipid complexes.
Fractal Analysis of Nuclear Medicine Images for the Diagnosis of Pulmonary Emphysema (2000)

The analysis of this study suggested that the fractal dimension defined in a previous report was limited to the indication of the percentage area of low-radioactivity regions with respect to total tissue area in the image. Because the fractal dimension partially reflects, but is not specific to, a certain degree of focal spots of low radioactivity, we suggest using fractal analysis in clinical practice only with careful control and thorough understanding of the physical meanings.
Optical turbulence and spectral condensate in long fibre lasers (2012)

We study numerically optical turbulence using the particular example of a recently created, ultra-long fibre laser. For normal fibre dispersion, we observed an intermediate state with an extremely narrow spectrum (condensate), which experiences instability and a sharp transition to a fluctuating regime with a wider spectrum. We demonstrate that the number of modes has an impact on the condensate's lifetime. The smaller the number of modes, the more resistant is the condensate to perturbations. Experimental results show a good agreement with numerical simulations.