gebhart/patrepeval huggingface dataset:
Angle-domain common-image gathers for migration velocity analysis by wavefield-continuation imaging (2004)

Abstract We analyze the kinematic properties of offset-domain common image gathers (CIGs) and angle-domain CIGs (ADCIGs) computed by wavefield-continuation migration. Our results are valid regardless of whether the CIGs were obtained by using the correct migration velocity. They thus can be used as a theoretical basis for developing migration velocity analysis (MVA) methods that exploit the velocity information contained in ADCIGs. We demonstrate that in an ADCIG cube, the image point lies on the normal to the apparent reflector dip that passes through the point where the source ray intersects the receiver ray. The image-point position on the normal depends on the velocity error; when the velocity is correct, the image point coincides with the point where the source ray intersects the receiver ray. Starting from this geometric result, we derive an analytical expression for the expected movements of the image points in ADCIGs as functions of the traveltime perturbation caused by velocity errors. By applying this analytical result and assuming stationary raypaths (i.e., small velocity errors), we then derive two expressions for the residual moveout (RMO) function in ADCIGs. We verify our theoretical results and test the accuracy of the proposed RMO functions by analyzing the migration results of a synthetic data set with a wide range of reflector dips. Our kinematic analysis leads also to the development of a new method for computing ADCIGs when significant geological dips cause strong artifacts in the ADCIGs computed by conventional methods. The proposed method is based on the computation of offset-domain CIGs along the vertical-offset axis and on the “optimal” combination of these new CIGs with conventional CIGs. We demonstrate the need for and the advantages of the proposed method on a real data set acquired in the North Sea.
Optimizing Ray-Triangle Intersection via Automated Search (2006)

In this paper, we examine existing direct 3D ray-triangle intersection tests (i.e., those that do not first do a ray-plane test followed by a 2D test) for ray tracing triangles and show how the majority of them are mathematically equivalent. We then use these equivalencies to attempt faster intersection tests for single rays, ray packets with common origins, and general ray packets. We use two approaches, the first of which counts operations, and the second of which uses benchmarking on various processors as the fitness function of an optimization procedure. Finally, the operation-counting method is used to further optimize the code produced via the fitness function
Novel Designs of Turbine Blades for Additive Manufacturing (2016)

Improving engine performance requires creating new materials and improving design and manufacturing. Additive Manufacturing (AM) is advancing rapidly and allows us to produce details of complex shapes that cannot be produced by traditional methods. The goal of this study was to demonstrate the possibility of using AM for the manufacture of turbine blades with a complex geometry, including those with advanced cooling systems, which cannot be manufactured by conventional methods. This paper presents the results of the design and calculations of high-pressure turbine (HPT) cooled blades, as well as a low-pressure turbine (LPT) uncooled blade that was designed using topology optimization (TO). Several blades were manufactured using AM. 3D tomography test results for those blades confirm the possibility of AM application in production of blades with complex geometry.
Promoting Apoptosis (2010)

The promyelocytic leukemia protein likely influences apoptosis by influencing a calcium channel in the endoplasmic reticulum.
Novel amyloid precursor protein gene mutation (codon 665<sup>Asp</sup>) in a patient with late‐onset Alzheimer's disease (1994)

Amyloid plaques in Alzheimer's disease contain beta-amyloid, encoded by portions of exons 16 and 17 of the amyloid precursor protein. The specific association of rare amyloid precursor protein mutations with some kindreds with early-onset familial Alzheimer's disease suggests that specific abnormalities in amyloid precursor protein may contribute to the pathogenesis of Alzheimer's disease. Until now, there has been no evidence suggesting that amyloid precursor protein mutations could be involved in late-onset or sporadic Alzheimer's disease. We used reverse transcription-polymerase chain reaction, denaturing gradient gel electrophoresis, and direct DNA sequencing to analyze amyloid precursor protein exons 16 and 17 from postmortem cerebellar samples from patients with histologically confirmed Alzheimer's disease and control subjects. We found a novel point mutation, substitution of cytosine for guanine, at nucleotide 2119 (amyloid precursor protein 770 messenger RNA transcript) in a patient with late-onset Alzheimer's disease. This substitution deletes a BglII site and substitutes aspartate for glutamine at codon 665. Denaturing gradient gel electrophoresis analysis showed that this mutation was absent in 40 control subjects and 127 dementia patients. Whether this mutation is a rare but normal variant or contributes to the development of Alzheimer's disease is not known. The BglII restriction fragment length polymorphism enables investigators to determine the frequency of this polymorphism in normal subjects and Alzheimer's disease patients.
Improving surgical precision--application of navigation system in orthopedic surgery. (2008)

Navigation systems track objects with precision expressed as root mean square equalling even up to 0.15 mm. Application of navigation system combined with imaging technique makes surgical operations less invasive, which results in the reduced risk of infection, smaller scar and a shorter time of rehabilitation. Imaging techniques allow surgeon to create individual virtual models for virtual surgery planning. Navigation system tracks the positions of surgical tools in relation to the patient's coordinate systems. Medical imaging enables low-invasive surgery, whereas the position of surgical instruments is monitored on screen. The paper presents a newly developed computer-aided surgical system consisting of ultrasonographic probe and tracking system to measure bone geometry, design surgical scenario virtually and follow it intraoperatively. The system assists surgeon to correct bone deformities. The paper presents the results of several accuracy tests, which demonstrate good repeatability and accuracy.
A computational approach for solution of boundary layer equations for the free convection along a vertical plate (2015)

In this letter, the shifted Legendre polynomials are employed for solving the natural heat convection heat transfer. The operational matrix of derivative for the shifted Legendre polynomial are derived. Then the shifted Legendre polynomials expansion
Evaluation of Immunogenicity of an Oral Salmonella Vaccine Expressing Recombinant Plasmodium berghei Merozoite Surface Protein-1 (1997)

A repetitive region of Plasmodium berghei merozoite surface protein-1 (PbMSP-1) was expressed as a fusion protein with either maltose binding protein or the B subunit of heat-labile enterotoxin from Escherichia coli. Vaccination of mice with the fusion proteins indicates that this region of PbMSP-1 is antigenic as evidenced by an antibody response. The fusion proteins were also expressed in Salmonella and mice were orally immunized with the recombinant Salmonella. Some of the vaccinated mice survived a challenge with P. berghei blood-stage parasites without developing parasitemia. All control mice became patent and succumbed to the challenge infection. This partial protection was also observed with purified recombinant protein and was independent of the adjuvant used. Mice immunized with recombinant Salmonella showed either extremely low or no antibody response to PbMSP-1, suggesting that cell-mediated immunity is important for the observed protection. These studies show that it is feasible to develop a cost effective oral vaccine against the blood stage of the malarial parasite.
GSI: Geo Scene Investigation! On-site Programming (Grade 7) (2008)

GSI: Geo Scene Investigation! introduces students to the differences between observations and interpretations and to some of the fundamental principles of geology. Students identify specific geologic processes and landforms in the landscape surrounding them at Lake Mead National Recreation Area (NRA) by solving mysteries with a set of geology-related clues.
Particle levitation and guidance in hollow-core photonic crystal fiber (2002)

We report the guidance of dry micron-sized dielectric particles in hollow core photonic crystal fiber. The particles were levitated in air and then coupled to the air-core of the fiber using an Argon ion laser beam operating at a wavelength of 514 nm. The diameter of the hollow core of the fiber is 20 m . A laser power of 80 mW was sufficient to levitate a 5 m diameter polystyrene sphere and guide it through a ~150 mm long hollow-core crystal photonic fiber. The speed of the guided particle was measured to be around 1 cm/s.
Whole genome analysis of hepatitis B virus from four cases of fulminant hepatitis: genetic variability and its potential role in disease pathogenicity (1996)

The precore stop-codon variant of hepatitis B virus (HBV) has been associated with fulminant hepatitis but is also found in patients with persistent infection and chronic hepatitis. We have examined the possibility that the severe outcome of infection in patients with fulminant disease may be a result of additional genomic variation. We sequenced the entire HBV genome from three patients of Greek and one patient of Chinese origin with fulminant hepatitis, and from two patients with hepatitis B e antigen (HBeAg) positive chronic infection from the same regions, using direct sequencing of amplified viral DNA. Three of the fulminant cases were infected with the precore stop-codon variant HBeAg negative) and the fourth with the wild-type (HBeAg) positive virus. We compared sequences from our four fulminant isolates, and an additional fulminant isolate reported by others, with HBeAg positive carriers from the same regions and 12 published HBV genomes. There was a higher number of nucleotide and amino-acid substitutions throughout the HBV genome in the precore variant fulminant sequences than in the wild type. A cluster of mutations previously identified in the X region (126-132) in sequences reported in Japanese patients and encompassing the Enhancer II-Core Promoter region (1751-1768), were not found in our patients. We conclude that although there are no changes common to all sequences of HBV isolates from fulminant cases, some of these changes are in recognized cis-acting regulatory elements, whilst others are in the immediate vicinity of such elements. The effect of these mutations on viral genome transcription must now be determined.
Calcium binding to the epidermal growth factor homology region of bovine protein C. (1988)

A high affinity calcium binding site that is independent of the gamma-carboxyglutamic acid-rich amino-terminal region, has been demonstrated in bovine protein C, as well as in the other vitamin K-dependent proteins (except prothrombin) involved in blood coagulation. gamma-Carboxyglutamic acid-independent calcium binding in protein C is required for its rapid activation by the thrombin-thrombomodulin complex. We have now isolated a Ca2+-binding fragment from a tryptic digest of bovine protein C. The isolated fragment contains the two domains that are homologous to the epidermal growth factor precursor from the light chain of protein C, and a small disulfide bound peptide derived from the heavy chain. The isolated fragment bound 1 mol of Ca2+/mol of protein with a dissociation constant (Kd) of approximately 1 x 10(-4) M. This is similar to the Kd previously determined for binding of a single Ca2+ ion to protein C lacking the gamma-carboxyglutamic acid region. Immunochemical evidence indicated that Ca2+ binding induced a conformational change both in protein C lacking the gamma-carboxyglutamic acid region and in the isolated fragment.
Characteristics of Dasatinib- and Imatinib-Resistant Chronic Myelogenous Leukemia Cells (2008)

These results suggest that the expression and protein activation signatures identified in this study provide insight into the mechanism of resistance to dasatinib and imatinib and may be of therapeutic chronic myelogenous leukemia value clinically.
Measurement of serum monoclonal components: comparison between densitometry and capillary zone electrophoresis (2006)

Quantitative measurement of serum monoclonal protein (M-protein) is one of the most important tools for monitoring disease activity in monoclonal gammopathies. The aims of this study were to evaluate serum M-protein quantification by capillary zone electrophoresis (CZE) and to compare results with those obtained by densitometric scanning of high-resolution agarose gel electrophoresis (HRE-AGE). The evaluation was carried out on 82 samples from patients with various monoclonal gammopathies. All the suspected M-proteins were confirmed and characterised by immunofixation on agarose gel (IFE). CZE was performed on a Paragon CZE 2000 system (Beckman Coulter). Passing-Bablok regression was: y (CZE)=1.27 x(HRE-AGE)-5.21 g/L. The correlation coefficient was 0.92. Bland-Altman analysis demonstrated a mean difference of -1.83 g/L (95% CI -0.76 to -2.90) with clear evidence of a concentration-related bias. Densitometry gave higher values at low M-spikes (<20 g/L), whereas CZE gave higher values at large M-spikes (>20 g/L). The concentration-related bias was found to be independent of the immunoglobulin isotype. In conclusion, to compare previous results obtained by M-protein densitometric scanning with those obtained by direct measurement of CZE peaks, the calculation of a univocal transforming factor appears to be unreliable.
Synthesis of some polyimidazole ligands related to zinc enzymes (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of some polyimidazole ligands related to zinc enzymesRonald Breslow, John T. Hunt, Richard Smiley, and Thomas TarnowskiCite this: J. Am. Chem. Soc. 1983, 105, 16, 5337–5342Publication Date (Print):August 1, 1983Publication History Published online1 May 2002Published inissue 1 August 1983https://pubs.acs.org/doi/10.1021/ja00354a025https://doi.org/10.1021/ja00354a025research-articleACS PublicationsRequest reuse permissionsArticle Views1302Altmetric-Citations61LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Blocking ligand occupancy of the αVβ3 integrin inhibits insulin-like growth factor I signaling in vascular smooth muscle cells (1998)

Blocking alphaVbeta3 integrin occupancy results in attenuation of the cellular migration response to insulin-like growth factor I (IGF-I). To determine whether integrin antagonists alter other IGF-I-stimulated biologic actions, quiescent smooth muscle cells (SMCs) were exposed to echistatin and their ability to respond to IGF-I was determined. Echistatin (10(-7) M) inhibited IGF-I-stimulated DNA synthesis by 80%, and the protein synthesis response also was inhibited. Therefore blocking occupancy of alphaVbeta3 inhibited multiple target cell actions of IGF-I. To determine whether blocking alphaVbeta3 occupancy could alter IGF-I receptor-mediated signal transduction, the ability of IGF-I to stimulate phosphorylation of insulin receptor substrate-1 (IRS-1) was analyzed. A 10-min exposure to 100 ng/ml of IGF-I resulted in a substantial increase in phosphorylated IRS-1, and echistatin (10(-7) M) blocked the IGF-I-induced IRS-1 phosphorylation response. Echistatin also attenuated downstream signaling because the capacity of the p85 subunit of phosphatidylinositol-3 kinase (PI-3 kinase) to bind to IRS-1 was blocked. In contrast, exposure of SMCs to vitronectin (1.0 micrograms/cm2) or thrombospondin (0.25 micrograms/cm2), two known ligands for alphaVbeta3, resulted in enhancement of the IGF-I-stimulated IRS-1 response. To determine whether these effects were caused by alterations in receptor kinase activity, the IGF-I receptor was immunoprecipitated and then analyzed for phosphotyrosine. Echistatin (10(-7) M) significantly reduced IGF-I-stimulated tyrosine phosphorylation of the IGF-I receptor beta subunit. We conclude that occupancy of the alphaVbeta3 integrin is necessary for IGF-I to fully activate the kinase activity of the IGF-I receptor and phosphorylate IRS-1. Activation of the alphaVbeta3 receptor results in an interaction with the IGF-I signal transduction pathway, which modulates SMCs responsiveness to IGF-I.
Video-on-demand: experience with protocols and their implementation (2002)

This paper summarizes some observations made during our research project aiming at investigating the practical problems encountered during the implementation of interactive multimedia information systems. The prototype deals with digitally compressed information encoded in MPEG-2 formats. We have opted for the use of a set of standard protocols. In this paper we give a brief description and critique of these standard protocols and discuss some aspects related to their implementation. We have specifically focused here on the MPEG-2 Digital Storage Media Command and Control (DSM-CC) protocol.
Negative regulation of the human apolipoprotein A-I promoter by fibrates can be attenuated by the interaction of the peroxisome proliferator-activated receptor with its response element. (1994)

Fibrates have been reported to modulate plasma high density lipoprotein cholesterol and apolipoprotein (apo) A-I concentrations. Therefore, the molecular mechanisms underlying the regulation of human apoA-I gene expression by fibrates was investigated. Fenofibrate reduced the expression of a reporter gene driven by the DNA sequences between -192 and +91 (BC-P-chloramphenicol acetyltransferase; CAT) relative to the apoA-I gene transcription start site approximately 3-fold. The sequences involved in the down-regulation of apoA-I gene transcription by fenofibrate were localized between -41 and +91 (P-CAT) relative to the transcription start site. The reduction of the expression of BC-P-CAT was dose-dependent and maximal at 500 microM (20 +/- 7%). Different peroxisome proliferators showed different levels of repression varying from 39 +/- 4% for fenofibrate, 43 +/- 5% for tetradecylthioacetic acid, 48 +/- 4% for bezafibrate, 54 +/- 2% for 5,8,11,14-eicotetraynoic acid, 76 +/- 2% for ciprofibrate, whereas Wy 14643 only marginally inhibited the expression of BC-P-CAT. By contrast, inclusion of sequences between -256 and -192 (ABC-P-CAT) attenuated the repression by fenofibrate. Furthermore, the apoA-IA site (-214 to -192; Awt-P-CAT) could counteract the repression of P-CAT by fenofibrate in the presence of cotransfected mPPAR alpha (peroxisome proliferator-activated receptor). In addition, the acyl-CoA oxidase-peroxisome proliferator response element (PPRE) could substitute the wild-type A-site in blocking the fenofibrate-induced reduction of the apoA-I promoter by mPPAR alpha. The protective effect of PPAR on fenofibrate induced inhibition of apoA-I expression was abolished after mutation of the direct repeat in the A site (Am-P-CAT). Consistent with these functional data only the wild-type, but not the mutated A site bound PPAR/retinoic X receptor heterodimers in gel shift assays. These data suggest that certain peroxisome proliferators can reduce the expression of the apoA-I promoter in a PPAR-independent fashion, through modulation of factors interacting with sequences localized between -41 and +91 of the apoA-I gene transcription initiation site. This inhibitory effect can be overcome when PPAR interacts with a functional PPRE, such as the apoA-I A site or the acyl-CoA oxidase-PPRE.
Evaluation of Fungicides for Control of Powdery Mildew on Lettuce in 2002 (2002)

Powdery mildew on lettuce is caused by the fungus Erysiphe cichoracearum. This disease is favored by moderate to warm temperatures and dry weather conditions. Several potential new fungicides were evaluated for control of powdery mildew on lettuce in 2002. Powdery mildew appeared in our plots by February 15 and reached moderate levels of severity by plant maturity on March 6 to 8th. Nontreated lettuce plants were moderately infected with powdery mildew at plant maturity, whereas the level of disease was low to virtually nonexistent in plots treated with Microthiol Disperss, Rally, Quinoxyfen, Flint, and Rally alternated with Kaligreen. Furthermore, other tested products provided moderate suppression of powdery mildew. The future availability of one or more of the tested chemistries not currently registered for lettuce could help in efforts to control powdery mildew on this crop and to establish and maintain a fungicide resistance management program for plant disease control products.
Cholesterol expels ibuprofen from the hydrophobic membrane core and stabilizes lamellar phases in lipid membranes containing ibuprofen (2015)

There is increasing evidence that common drugs, such as aspirin and ibuprofen, interact with lipid membranes. Ibuprofen is one of the most common over the counter drugs in the world, and is used for relief of pain and fever. It interacts with the cyclooxygenase pathway leading to inhibition of prostaglandin synthesis. From X-ray diffraction of highly oriented model membranes containing between 0 and 20 mol% ibuprofen, 20 mol% cholesterol, and dimyristoylphosphatidylcholine (DMPC), we present evidence for a non-specific interaction between ibuprofen and cholesterol in lipid bilayers. At a low ibuprofen concentrations of 2 mol%, three different populations of ibuprofen molecules were found: two in the lipid head group region and one in the hydrophobic membrane core. At higher ibuprofen concentrations of 10 and 20 mol%, the lamellar bilayer structure is disrupted and a lamellar to cubic phase transition was observed. In the presence of 20 mol% cholesterol, ibuprofen (at 5 mol%) was found to be expelled from the membrane core and reside solely in the head group region of the bilayers. 20 mol% cholesterol was found to stabilize lamellar membrane structure and the formation of a cubic phase at 10 and 20 mol% ibuprofen was suppressed. The results demonstrate that ibuprofen interacts with lipid membranes and that the interaction is strongly dependent on the presence of cholesterol.