gebhart/patrepeval huggingface dataset:
Sex-specific quantitative trait loci affecting longevity in <i>Drosophila melanogaster</i> (1997)

Senescence, the decline in survivorship and fertility with increasing age, is a near-universal property of organisms. Senescence and limited lifespan are thought to arise because weak natural selection late in life allows the accumulation of mutations with deleterious late-age effects that are either neutral (the mutation accumulation hypothesis) or beneficial (the antagonistic pleiotropy hypothesis) early in life. Analyses of Drosophila spontaneous mutations, patterns of segregating variation and covariation, and lines selected for late-age fertility have implicated both classes of mutation in the evolution of aging, but neither their relative contributions nor the properties of individual loci that cause aging in nature are known. To begin to dissect the multiple genetic causes of quantitative variation in lifespan, we have conducted a genome-wide screen for quantitative trait loci (QTLs) affecting lifespan that segregate among a panel of recombinant inbred lines using a dense molecular marker map. Five autosomal QTLs were mapped by composite interval mapping and by sequential multiple marker analysis. The QTLs had large sex-specific effects on lifespan and age-specific effects on survivorship and mortality and mapped to the same regions as candidate genes with fertility, cellular aging, stress resistance and male-specific effects. Late age-of-onset QTL effects are consistent with the mutation accumulation hypothesis for the evolution of senescence, and sex-specific QTL effects suggest a novel mechanism for maintaining genetic variation for lifespan.
Transient decrease in water diffusion observed in human occipital cortex during visual stimulation (2001)

Using MRI, we report the observation of a transient decrease of the apparent diffusion coefficient (ADC) of water in the human brain visual cortex during activation by a black and white 8-Hz-flickering checkerboard. The ADC decrease was small (<1%), but significant and reproducible, and closely followed the time course of the activation paradigm. Based on the known sensitivity of diffusion MRI to cell size in tissues and on optical imaging studies that have revealed changes in the shape of neurons and glial cells during activation, the observed ADC findings have been tentatively ascribed to a transient swelling of cortical cells. These preliminary results suggest a new approach to produce images of brain activation with MRI from signals directly associated with neuronal activation, and not through changes in local blood flow.
Countercurrent Laminar Microflow for Highly Efficient Solvent Extraction (2006)

By modifying the walls of a glass microchannel so that one side is hydrophilic and the other hydrophobic, countercurrent laminar flow of an organic phase relative to an aqueous phase is effected (see picture). This system is applied to the efficient extraction of a cobalt complex from toluene into water. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z600122_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Microstrip plasma limiter (2003)

An operational microstrip plasma limiter was developed for DC to 18-GHz operation. The limiter threshold is 65 W for a 1- mu s microwave pulse. Spike leakages of less than 20 mu J and flat leakage of less than 1 W were achieved from S- to X-band. The power handling capacity is 50 kW peak. Insertion loss is higher than expected but can be reduced with better control of mismatches between transmission media. As expected the spike leakage is highest when the incident pulse is just above the firing threshold. The statistics of the spike energy leakage at X-band for intermediate power levels have been measured and are being investigated.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The VIBR OTEM method (1999)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1999The VIBR OTEM methodAuthors: Stefan L. HelwigTilman HansteinAndreas HördtStefan L. HelwigUniversity of Cologne, Tilman HansteinUniversity of Cologne, and Andreas HördtUniversity of Colognehttps://doi.org/10.1190/1.1821001 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1821001FiguresReferencesRelatedDetailsCited ByQuantitative analysis of the anti-noise performance of an m -sequence in an electromagnetic method22 January 2018 | Journal of Geophysics and Engineering, Vol. 15, No. 1Shaping optimal transmitter waveforms for marine CSEM surveysGEOPHYSICS, Vol. 73, No. 3 SEG Technical Program Expanded Abstracts 1999ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1999 Pages: 2061 publication data© 1999 Copyright © 1999 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 04 Jan 2005 CITATION INFORMATION Stefan L. Helwig, Tilman Hanstein, and Andreas Hördt, (1999), "The VIBR OTEM method," SEG Technical Program Expanded Abstracts : 283-285. https://doi.org/10.1190/1.1821001 Plain-Language Summary PDF DownloadLoading ...
Effects of Even-Order Nonlinear Terms on Power Amplifier Modeling and Predistortion Linearization (2004)

Power amplifier (PA) is an essential component in communication systems and is nonlinear in nature. Digital baseband predistortion is an emerging cost effective approach to linearize a PA. To study PA nonlinear characteristics and to construct a predistorter, accurate nonlinear models are often necessary. Polynomials have been used extensively for modeling the behavior of the PA or the predistorter. For bandpass communication signals, attention has been paid mainly to odd-order nonlinear terms. In this paper, we reveal the benefit of including even-order nonlinear terms in baseband modeling of the PA and in enhancing predistortion performance.
Frequency synthesized and continuously tunable IR laser sources in 9-11 µm (1984)

A review of high-resolution microwave-tuned IR laser source with frequency-synthesized outputs exceeding 100 mW is presented. Details are given on system configuration, design parameters, tradeoff analysis, system optimization, and fabrication procedure, along with measured performance characteristics.
Self-polar double configurations in projective geometry: I. A general condition for self-polarity (1965)

Let be a p×q matrix of linear forms in the n+1 coordinates in a projective space Π n . Then points which satisfy the q equations in general span a space Π n-q , but will span a space Π n-q+1 if a set μ,={μ β of multipliers can be found such that Such a set μ can be found if and only if the equations have solutions.
An application of Petri net reduction for Ada tasking deadlock analysis (1996)

As part of our continuing research on using Petri nets to support automated analysis of Ada tasking behavior, we have investigated the application of Petri net reduction for deadlock analysis. Although reachability analysis is an important method to detect deadlocks, it is in general inefficient or even intractable. Net reduction can aid the analysis by reducing the size of the net while preserving relevant properties. We introduce a number of reduction rules and show how they can be applied to Ada nets, which are automatically generated Petri net models of Ada tasking. We define a reduction process and a method by which a useful description of a detected deadlock state can be obtained from the reduced net's information. A reduction tool and experimental results from applying the reduction process are discussed.
In vitro destruction of urinary calculi by laser-induced stress waves. (1978)

A gas chromatog.-mass spectral study is made of trimethylsilylated derivs. of sorbose (I) and 2-L-xylo-hexulosonic acid (II); II can be prepd. by the Pt-catalyzed oxidn. of I by O. II (b-pyranose form) is probably obtained from I via b-sorbopyranose (III). Retention times and mass spectral data are given for III, II (a- or b-furanose), II (a-pyranose), II (b-pyranose), and ascorbic acid.
DC-offset and 1/f noise effects on AC-coupled direct-conversion receiver (2002)

This paper analyzes the performance of a direct-conversion receiver (DCR) with ac coupling in the presence of dc-offset and 1/f noise. The performance metric employed is the SNR after the digital signal processing, as it is ultimately the most relevant measure of performance. The ac coupling, which is employed to overcome the dc-offset noise, introduces intersymbol interference (ISI), whose effects can be effectively mitigated using an equalizer. Similarly, the equalizer can also be used to mitigate the 1/f noise, which is equivalent in its effect to ISI. Our analysis shows that the performance of the ac-coupled DCR is much more sensitive to the 1/f noise compared to the ac-coupling corner frequency. This suggests that minimizing the 1/f rolloff frequency is essential for achieving high performance direct-conversion reception.
Coherent Path Tracing (2009)

Packet tracing is a popular and efficient method for accelerating ray tracing. However, packet traversal techniques become inefficient when they are applied to path tracing since the secondary rays are incoherent. In this paper, we present a simple technique for improving the coherency of secondary rays. This technique uses the same sequence of random numbers for generating secondary rays for all the pixels in each sample. This improves the efficiency of the packet tracing algorithm but creates structured noise patterns in the image. We propose an interleaved sampling scheme that reduces the correlation in the noise and makes it virtually imperceptible in the final image. Coherent path tracing is unbiased, simple to implement, and outperforms standard path tracing with packet tracing, while producing images with similar RMS error values.
Brain–machine interfaces in neurorehabilitation of stroke (2014)

Stroke is among the leading causes of long-term disabilities leaving an increasing number of people with cognitive, affective and motor impairments depending on assistance in their daily life. While function after stroke can significantly improve in the first weeks and months, further recovery is often slow or non-existent in the more severe cases encompassing 30–50% of all stroke victims. The neurobiological mechanisms underlying recovery in those patients are incompletely understood. However, recent studies demonstrated the brain's remarkable capacity for functional and structural plasticity and recovery even in severe chronic stroke. As all established rehabilitation strategies require some remaining motor function, there is currently no standardized and accepted treatment for patients with complete chronic muscle paralysis. The development of brain–machine interfaces (BMIs) that translate brain activity into control signals of computers or external devices provides two new strategies to overcome stroke-related motor paralysis. First, BMIs can establish continuous high-dimensional brain-control of robotic devices or functional electric stimulation (FES) to assist in daily life activities (assistive BMI). Second, BMIs could facilitate neuroplasticity, thus enhancing motor learning and motor recovery (rehabilitative BMI). Advances in sensor technology, development of non-invasive and implantable wireless BMI-systems and their combination with brain stimulation, along with evidence for BMI systems' clinical efficacy suggest that BMI-related strategies will play an increasing role in neurorehabilitation of stroke.
Rapid agricultural supply chain risk assessment : a conceptual framework (2010)

This paper describes the methodology for a Rapid Agricultural Supply Chain Risk Assessment (RASCRA), developed by the Agricultural Risk Management Team (ARMT) of the World Bank. The primary objective of RASCRA is to help decision makers understand the risk exposure of agricultural supply chain participants and to improve risk management strategies for selected commodity systems. RASCRA provides a system-wide approach for identifying risks, risk exposure, the severity of potential loses, and options for risk management either by supply chain participants or by third parties. The aim of the assessment is to understand the wide range of bottlenecks and choke points that affect the participants and functions related to a given agricultural commodity system. The assessment encompasses direct supply chain participants, private and public sector support service providers, and the broader enabling environment the focus on risk assessment is motivated by the growing attention to agricultural risk from national governments, international agencies, financial institutions, producer organizations, consumer organizations, and other agents in the private sector. Also, recent food safety 'crises,' the outbreak and spread of avian influenza, major swings in food and other commodity prices, and growing concerns about climate change are among the many shocks and emerging trends that are raising the profile of agricultural risk and interest in more effective and sustainable risk management strategies and approaches.
On the track of Artificial Intelligence: Learning with Intelligent Personal Assistants (2016)

<p>In a technology dominated world, useful and timely information can be accessed quickly via Intelligent Personal Assistants (IPAs). By the use of these assistants built into mobile operating systems, daily electronic tasks of a user can be accomplished 24/7. Such tasks like taking dictation, getting turn-by-turn directions, vocalizing email messages, reminding daily appointments, setting reminders, responding any factual questions and invoking apps can be completed by IPAs such as Apple’s <a href="http://searchconsumerization.techtarget.com/definition/Siri" target="_blank">Siri</a>, <a href="http://whatis.techtarget.com/definition/Google-Now" target="_blank">Google Now</a> and Microsoft Cortana. The mentioned assistants programmed within Artificial Intelligence (AI) do create an interaction between human and computer through a natural language used in digital communication. In this regard, the overall purpose of this study is to examine the potential use of IPAs that use advanced cognitive computing technologies and Natural Language Processing (NLP) for learning. To achieve this purpose, the working system of IPAs is reviewed briefly within the scope of AI that has recently become smarter to predict, comprehend and carry out multi-step and complex requests of users.</p>
Serratia Protease (1970)

A strain of Serratia, isolated from an intestinal canal of a silkworm, produced a large quantity of protease. The enzyme was extracellular and was named Serratiopeptidase, tentatively. Protease production of this strain was over 3 times as much as that of Serratia marcescens which was known as a protease-producing organism. The highly purified enzyme was prepared from the culture supernatant through ammonium sulfate precipitation, acetone fractionation, DEAE-cellulose column chromatography and gel filtration on Sephadex G-75. The purified enzyme moved homogeneously with a sedimentation constant, s20, w of 3.8S in ultracentrifugation and the molecular weight was determined to be 6.0×104 by the Archibald method. Determination of the ultraviolet absorption spectrum indicated the E1%280mμ, 1cm was 13.0. Neither carbohydrate nor sulfur-containing amino acid was detected in the purified enzyme preparation. The enzyme showed maximal activity at pH 9.0 and at 40°C, and was stable under lower temperatures over the pH range from 5 to 10, whereas it was unstable at 37°C in alkaline conditions. The enzyme was completely inactivated by heating at 55°C for 15 min.
Nonsmoker Exposure to Secondhand Cannabis Smoke. III. Oral Fluid and Blood Drug Concentrations and Corresponding Subjective Effects (2015)

The increasing use of highly potent strains of cannabis prompted this new evaluation of human toxicology and subjective effects following passive exposure to cannabis smoke. The study was designed to produce extreme cannabis smoke exposure conditions tolerable to drug-free nonsmokers. Six experienced cannabis users smoked cannabis cigarettes [5.3% Δ(9)-tetrahydrocannabinol (THC) in Session 1 and 11.3% THC in Sessions 2 and 3] in a closed chamber. Six nonsmokers were seated alternately with smokers during exposure sessions of 1 h duration. Sessions 1 and 2 were conducted with no ventilation and ventilation was employed in Session 3. Oral fluid, whole blood and subjective effect measures were obtained before and at multiple time points after each session. Oral fluid was analyzed by ELISA (4 ng/mL cutoff concentration) and by LC-MS-MS (limit of quantitation) for THC (1 ng/mL) and total THCCOOH (0.02 ng/mL). Blood was analyzed by LC-MS-MS (0.5 ng/mL) for THC, 11-OH-THC and free THCCOOH. Positive tests for THC in oral fluid and blood were obtained for nonsmokers up to 3 h following exposure. Ratings of subjective effects correlated with the degree of exposure. Subjective effect measures and amounts of THC absorbed by nonsmokers (relative to smokers) indicated that extreme secondhand cannabis smoke exposure mimicked, though to a lesser extent, active cannabis smoking.
Characterization and replicase activity of double-layered and single-layered rotavirus-like particles expressed from baculovirus recombinants (1996)

Rotavirus has a capsid composed of three concentric protein layers. We coexpressed various combinations of the rotavirus structural proteins of single-layered (core) and double-layered (single-shelled) capsids from baculovirus vectors in insect cells and determined the ability of the various combinations to assemble into viruslike particles (VLPs). VLPs were purified by centrifugation, their structure was examined by negative-stain electron microscopy, their protein content was determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and GTP binding assays, and their ability to support synthesis of negative-strand RNAs on positive-sense template RNAs was determined in an in vitro replication system. Coexpression of all possible combinations of VP1, VP2, VP3, and VP6, the proteins of double-layered capsids, resulted in the formation of VP1/2/3/6, VP1/2/6, VP2/3/6, and VP2/6 double-layered VLPs. These VLPs had the structural characteristics of empty rotavirus double-layered particles and contained the indicated protein species. Only VPI/2/3/6 and VP1/2/6 particles supported RNA replication. Coexpression of all possible combinations of VPl, VP2, and VP3, the proteins of single-layered capsids, resulted in the formation of VP1/2/3, VP1/2, VP2/3, and VP2 single-layered VLPs. These VLPs had the structural characteristics of empty single-layered rotavirus particles and contained the indicated protein species. Only VP1/2/3 and VP1/2 VLPs supported RNA replication. We conclude that (i) the assembly of VP1 and VP3 into VLPs requires the presence of VP2, (ii) the role of VP2 in the assembly of VP1 and VP3 and in replicase activity is most likely structural, (iii) VP1 is required and VP3 is not required for replicase activity of VLPs, and (iv) VP1/2 VLPs constitute the minimal replicase particle in the in vitro replication system.
Immunocytochemical determination of estrogen receptor, progesterone receptor, and 1,25-dihydroxyvitamin D3 receptor in breast cancer and relationship to prognosis. (1991)

We have determined the estrogen receptor, progesterone receptor (PR), and 1,25-dihydroxyvitamin D3 receptor content of 136 breast carcinomas by an immunocytochemical method. The presence of the three receptors was not related to clinical features of presentation such as T-stage or to age or menopausal status. However, each of the three receptors has a different relationship to the course of the disease in these patients. The presence of PR was significantly associated with an improved overall survival (chi 2 = 4.61, P = 0.032). Patients whose tumors contained immunocytochemically detectable 1,25-dihydroxyvitamin D3 receptor had a longer disease-free interval than those patients with negative tumors (chi 2 = 4.01, P = 0.045). The presence of estrogen receptor and PR were found to correlate with an increased survival between relapse and death (P = 0.027 and P = 0.09, respectively). The relationships between estrogen receptor and PR and prognosis are more apparent when the degree of cell staining is considered. Combined receptor analysis improves our ability to predict the course of the disease and may therefore facilitate better management of the patients.
Biotransformation of Ergot Alkaloids by Haloperoxidase from <i>Streptomyces aureofaciens</i>: Stereoselective Acetoxylation and Propionoxylation (1997)

Abstract Agroclavine ( 1 ) was oxidized, by haloperoxidase from Streptomyces aureofaciens , to 2,3‐dihydro‐6,8‐dimethyl‐3β‐acetoxy‐8‐ergolen‐2‐one ( 2 ) in the presence of sodium acetate and bromine ions. Acetate was incorporated into the above product during oxidation. In a propionate buffer, incorporation of propionate into the product was observed, yielding 2,3‐dihydro‐6,8‐dimethyl‐3β‐propionoxy‐8‐ergolen‐2‐one ( 4 ). The biotransformation proceeded faster in the propionate buffer, affording also the higher oxidation product (4a S ),(10b S )‐7‐amino‐3,4,4a,5,6,10b‐hexahydro‐2,4‐dimethyl‐6‐oxobenzo[ f ]quinoline ( 3 ).
Advanced signal processing aspects of automatic speech recognition (1985)

Some day, machines that recognise speech will be commonplace. People will talk to computers, typewriters, toys, TV sets, household appliances, cars, door locks and wrist-watches. Before looking at the signal processing and pattern processing that will be the basis of the next generation of automatic speech-recognition systems, we consider the nature of the signal that these devices will have to deal with.
Electrochemical Impedance of Coated Metal Undergoing Loss of Adhesion (1993)

A critical analysis of the concepts used to correlate parameters determined from electrochemical impedance spectra to the evaluation of the loss of adhesion of an organic coating from steel is made. In particular, the breakpoint method is called into question based on a theoretical analysis of the double layer capacitance of the coating/metal interface. A model for a coating undergoing disbonding about a macroscopic defect is described. The impedance of a fusion-bonded epoxy (FBE) pipeline coating about a large defect is considered in light of this model. The observations approach characteristics predicted by the model.
2011 Indiana Interstate Mobility Report—Full Version (2012)

The 2011 Mobility Report—Full Version introduces the use of crowd sourced probe data collected from vehicles and mobile devices to quantify the location and duration of congestion on Indiana interstates. The report presents a detailed case study presented of the I-65 corridor, as well as examples of travel time reliability information for sections of Interstates 65, 70, and 94. Summary monthly mobility statistics for all 943 centerline miles of Indiana Interstates 64, 65, 69, 70, 74, 94, and 465 are tabulated in a graphical format to facilitate comparison of mobility along those corridors. The report contains three appendices. Appendix A details the location of congestion pockets on each corridor. Appendix B provides quantitative summary of congestion for each interstate by month and direction. Appendix C provides travel time reliability statistics along three corridors in northern Indiana, twelve corridors in central Indiana, and four corridors in southern Indiana.