gebhart/patrepeval huggingface dataset:
Importance of an Intact Growth Hormone/Insulin-Like Growth Factor 1 Axis for Normal Post-Infarction Healing: Studies in Dwarf Rats (2001)

Treatment with GH attenuates remodeling and improves left ventricular function in the setting of experimental heart failure following coronary ligation. This study was designed to test the hypothesis that an intact GH/insulin-like growth factor 1 (IGF-1) axis is required for normal myocardial infarction healing. Myocardial infarction was induced by coronary ligation in GH-deficient dwarf rats and in age-matched controls. In dwarf rats, serum IGF-1 levels were reduced by 50%, and grow rate was 50% less than normal littermates, although no differences in myocardial IGF-1 messenger RNA levels were observed compared with controls. All rats underwent transthoracic echocardiography at baseline, 2 weeks, and 6 weeks after myocardial infarction. Left ventricular end-diastolic pressure was obtained by in vivo closed chest catheterization. At 6 weeks, both infarcted groups exhibited similar myocardial infarction size at transthoracic echocardiography and at morphometric histology. In both groups with myocardial infarction, there was significant left ventricular dilation and reduced systolic function. However, the extent of remodeling as assessed by the increase in end-diastolic dimension (%Δ + 36 ± 5 vs. +19 ± 4; P < 0.01) and depression of function (%Δ fractional shortening −12 ± 2 vs. −7 ± 1; P < 0.01) were both greater in the dwarf group. Furthermore, dwarf rats failed to develop compensatory hypertrophy of noninfarcted posterior wall (%Δ posterior wall +5 ± 1 vs. +15 ± 3; P < 0.01). Therefore, pathologic left ventricular remodeling and functional loss following myocardial infarction is more marked in conditions of GH deficiency. An intact GH/IGF-1 axis appears necessary for a normal response to myocardial infarction injury in the rat.
Child immunisation levels in Sydney's Western Metropolitan Region: parental attitudes and nurses' roles. (1993)

Research was undertaken to examine childhood immunisation uptake rates, parental attitudes towards immunisation and immunisation services and parents' perceptions of health workers' (especially nurses') contribution to immunisation in the Western Metropolitan Region of Sydney, NSW. After a pilot study a questionnaire was distributed by teachers to a random sample of 450 parents of kindergarten children living in the Region. Data revealed an 84% childhood immunisation rate for all scheduled immunisations up to five years with a partial immunisation rate of 10% (6% did not answer or had gaps in immunisation information). The most significant factors associated with partial immunisation were found to be the socioeconomic and educational status of the children's fathers and itinerancy. Parents of partially immunised children were significantly more likely than parents of totally immunised children to consider that serious side-effects to immunisation do occur. The research also found that parents have a knowledge deficit about the seriousness of measles; that immunisation services in the Region have significant deficiencies and that nurses have a low profile and poor image in the provision of those services. As Early Childhood nurses were considered by parents as providing the most appropriate immunisation nursing service, their further involvement in promoting and extending services is recommended.
Effects of human colony-stimulating factor on the uptake and destruction of a pathogenic parasite (<i>Trypanosoma cruzi</i>) by human neutrophils. (1986)

The ability of granulocyte-macrophage colony-stimulating factor (CSF-H) to modulate human neutrophil functions was studied by using an in vitro system in which this cell type interacted with intracellular (amastigote [AMA]) forms of Trypanosoma cruzi. The presence of CSF-H during the 30-min period of neutrophil incubation with the AMA markedly enhanced parasite internalization. This effect was evidenced by significant increases in both the percentage of neutrophils incorporating AMA and the average number of AMA per 100 neutrophils with respect to mock-treated neutrophils. Pretreatment of the neutrophils with CSF-H reproduced the enhancement effect, whereas pretreatment of the AMA had no detectable consequence. The minimal neutrophil CSF-H pretreatment period required to significantly increase the number of AMA per 100 neutrophils was 20 min--suggesting that CSF-H induced time-dependent events ultimately leading to the manifestation of the noted effect--but neutrophil treatment with CSF-H for longer periods of time (up to 60 min) caused a much greater enhancement. Consistent with the notion of a regulatory action of CSF-H on neutrophils was the fact that the enhancing effect subsided gradually after removal of the factor and was no longer detectable after 16 hr. When 3H-labeled AMA were used, CSF-H-treated neutrophils released greater amounts of radiolabeled substances than mock-treated cells, indicating a stimulatory effect of CSF-H on the killing capacity of neutrophils. This was confirmed by the fact that untreated neutrophils that had internalized 3H-AMA killed the parasites at a faster rate when subsequently incubated with CSF-H. Catalase, but not superoxide dismutase, mannitol, benzoate, or histidine, inhibited neutrophil killing of the 3H-AMA whether the granulocytes had been exposed to CSF-H or not. This indicated that the cytotoxic mechanism involved the production of hydrogen peroxide in both cases, but possibly at a higher rate in the CSF-H-treated neutrophils. These results point to a regulatory effect of CSF-H on neutrophils that promotes cellular activities that might be relevant to the mechanisms of clearance of T. cruzi in vivo.
Abstract 2670: Time to Granulocyte-Colony Stimulating Factor Treatment after Acute Myocardial Infarction Does Not Affect Left Ventricular Recovery: Results from the STEMMI Trial (2007)

Introduction: Granulocyte-colony stimulating factor (G-CSF) therapy after a STEMI does not affect left ventricular systolic function when compared to placebo. However, recent human and animal studies suggest that the timing of G-CSF therapy is crucial. Hypothesis: G-CSF improves recovery of left ventricular ejection fraction if administered very early after a STEMI. Methods: The STEMMI trial MRI-subpopulation was analyzed. The trial included 58 patients (47 men; 56 [SD 9] years) with STEMI treated with primary PCI <12 hours after symptom onset. Patients were randomized to double blind treatment with G-CSF (10 μg/kg/day) or placebo for 6 days. Treatment with G-CSF (time to G-CSF) was initiated 30 hours (range 17 – 65) after PCI. Left ventricular function was evaluated with cardiac MRI and analyzed by an independent blinded core laboratory. Results: Circulating CD34+ cells increased during G-CSF therapy. However, there was no correlation between time to G-CSF and maximum plasma concentration of CD34+ cells (r=-0.3, p=0.2). Baseline ejection fraction was independent of time to G-CSF. The recovery of ejection fraction from baseline to 6 months was not associated with time to G-CSF (regression coefficient 0.2/hour, 95% CI -0.2 to 0.5), an identical improvement was found in the placebo group (p=0.8). There was no association between plasma concentrations of CD34+ cells and improvement in left ventricular function. Conclusions: We found no indication that early initiation of treatment with G-CSF improves recovery of left ventricular ejection fraction as compared to both late G-CSF and placebo. It remains to be determined if treatment initiation <17 hours after PCI improves recovery.
The Use of Achiral Ligands to Convey Asymmetry:  Chiral Environment Amplification (2000)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTThe Use of Achiral Ligands to Convey Asymmetry: Chiral Environment AmplificationJaume Balsells and Patrick J. WalshView Author Information P. Roy and Diane T. Vagelos Laboratories University of Pennsylvania, Department of Chemistry 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323 Cite this: J. Am. Chem. Soc. 2000, 122, 8, 1802–1803Publication Date (Web):February 11, 2000Publication History Received10 August 1999Published online11 February 2000Published inissue 1 March 2000https://pubs.acs.org/doi/10.1021/ja992892chttps://doi.org/10.1021/ja992892crapid-communicationACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views1195Altmetric-Citations85LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Catalysts,Chemical reactions,Ligands,Stereoselectivity,Titanium Get e-Alerts
The ConsensusPathDB interaction database: 2013 update (2012)

Knowledge of the various interactions between molecules in the cell is crucial for understanding cellular processes in health and disease. Currently available interaction databases, being largely complementary to each other, must be integrated to obtain a comprehensive global map of the different types of interactions. We have previously reported the development of an integrative interaction database called ConsensusPathDB (http://ConsensusPathDB.org) that aims to fulfill this task. In this update article, we report its significant progress in terms of interaction content and web interface tools. ConsensusPathDB has grown mainly due to the integration of 12 further databases; it now contains 215 541 unique interactions and 4601 pathways from overall 30 databases. Binary protein interactions are scored with our confidence assessment tool, IntScore. The ConsensusPathDB web interface allows users to take advantage of these integrated interaction and pathway data in different contexts. Recent developments include pathway analysis of metabolite lists, visualization of functional gene/metabolite sets as overlap graphs, gene set analysis based on protein complexes and induced network modules analysis that connects a list of genes through various interaction types. To facilitate the interactive, visual interpretation of interaction and pathway data, we have re-implemented the graph visualization feature of ConsensusPathDB using the Cytoscape.js library.
Sugeno, Mamdani, and fuzzy Mamdani controllers put in a uniform interpolation framework (1998)

In this paper we present a general framework for proving that fuzzy controllers are universal approximators. The framework results from the duality between fuzzy control and interpolation. An important aspect of this framework is its constructive nature, which allows us to prove the approximation capabilities of “crisp valued” as well as “fuzzy valued” fuzzy controllers. We also discuss a possible semantic interpretation of a fuzzy conclusion as a fuzzy restriction on the possible values a control action can take. Based on this semantic point of view, robust fuzzy controllers can be built. Where appropriate we refer to related work on the approximation capabilities of fuzzy controllers. © 1998 John Wiley & Sons, Inc.13: 243–256, 1998
Multistate Outbreaks of Foodborne Illness in the United States Associated With Fresh Produce From 2010 to 2017 (2019)

In the United States, the consumption of fresh fruits and vegetables has increased during recent years as consumers seek to make healthier lifestyle choices. However, the number of outbreaks associated with fresh produce that involve cases in more than one state (multistate) has increased concomitantly. As the distance along the farm-to-fork continuum has lengthened over time, there are also more opportunities for fresh produce contamination with bacterial pathogens before it reaches the consumer. This review provides an overview of the three bacterial pathogens (i.e., pathogenic <i>Escherichia coli, Listeria monocytogenes, and Salmonella enterica</i>) associated with multistate fresh produce outbreaks that occurred between 2010 and 2017 in the U.S. Possible routes of fresh produce contamination, including pre- and post-harvest, are summarized and outcomes of selected outbreaks within this timeframe are highlighted. Eighty-five multistate outbreaks linked to fresh produce with a confirmed etiology occurred from 2010 to 2017. Cross-contamination within the distribution chain and poor agricultural practices, along with the production of sprouts and importation of fresh produce were frequently implicated contributors to these events. The evolution of the food supply chain in the U.S. necessitates an examination of multistate outbreaks to shed light on factors that increase the scale of these events.
A construction of non-Reed-Solomon type MDS codes (1989)

A construction is presented of long maximum-distance-separable (MDS) codes that are not generalized Reed-Solomon (GRS) type. The construction uses subsets S, mod S mod =m of a finite field F=GF(q) with the property that no t distinct elements of S add up to some fixed element of F. Large subsets of this kind are used to construct (n=m+2, k=t+1) non-GRS MDS codes over F.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
On the Construction of Deflation-Based Preconditioners (2001)

In this article we introduce new bounds on the effective condition number of deflated and preconditioned-deflated symmetric positive definite linear systems. For the case of a subdomain deflation such as that of Nicolaides [SIAM J. Numer. Anal., 24 (1987), pp. 355--365], these theorems can provide direction in choosing a proper decomposition into subdomains. If grid refinement is performed, keeping the subdomain grid resolution fixed, the condition number is insensitive to the grid size. Subdomain deflation is very easy to implement and has been parallelized on a distributed memory system with only a small amount of additional communication. Numerical experiments for a steady-state convection-diffusion problem are included.
IP multicasting over ATM networks (1997)

The Internet protocol (IP) multicast model involves a combination of intrasubnet and intersubnet multicast mechanisms. Technologies supporting a given subnet are expected to have native mechanisms for supporting intrasubnet forwarding of packets sent to multicast destinations. Multicast routers attach to subnets and provide intersubnet forwarding of multicast packets, using interdomain multicast routing protocols developed by the Internet Engineering Task Force (IETF). Unfortunately, ATM networks based on UNI 3.0 or UNI 3.1 signaling service do not provide the native multicast support expected by IP. This has led the IETF to develop the "MARS model"-a fairly complex mechanism for emulating intrasubnet multicast support required when running IPs over ATMs. This paper takes a high level look at the IP multicast service, examines the limitations of the ATM point-to-multipoint virtual channel service, and describes the major architectural points of the MARS model.
Anti-CD163-dexamethasone protects against apoptosis after ischemia/reperfusion injuries in the rat liver (2015)

We show that pharmacological preconditioning with anti-CD163-dex and high dose dexamethasone reduces the number of apoptotic cells following ischemia/reperfusion injury.
Metal ion activation of nitriles. Syntheses of 1,3-bis(arylimino)isoindolines (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMetal ion activation of nitriles. Syntheses of 1,3-bis(arylimino)isoindolinesWalter O. SieglCite this: J. Org. Chem. 1977, 42, 11, 1872–1878Publication Date (Print):May 1, 1977Publication History Published online1 May 2002Published inissue 1 May 1977https://pubs.acs.org/doi/10.1021/jo00431a011https://doi.org/10.1021/jo00431a011research-articleACS PublicationsRequest reuse permissionsArticle Views2533Altmetric-Citations138LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Near-infrared electroluminescence based on perylenediimide-doped tris(8-quinolinolato) aluminum (2006)

For the purpose of exploring near-infrared emission, the photoluminescence (PL) and electro- luminescence (EL) of N,N′-bis(neopentyl)-3,4:9,10-perylenebis(dicarboximide) (BNPTCD): tris(8-quinolinolato)aluminum (Alq3) mixed films were investigated. It was found that BNPTCD:Alq3 mixed films exhibit PL in the near-infrared wavelength region and that organic light-emitting diodes using Alq3 highly doped with BNPTCD as an emitting layer exhibit near-infrared EL with a peak at 805 nm originating from BNPTCD aggregates.
MultiSync: a synchronization model for multimedia systems (1996)

Synchronization among various media sources is one of the most important issues in multimedia communications and various audio/video (A/V) applications. For continuous playback (such as lip synchronization) under a time-sharing multiprocessing operating system (such as UNIX), the synchronization quality of traditional synchronization mechanisms employed on single processes may vary according to the workload of the system. When the system encounters an overload situation, the synchronization usually fails and, even worse, results in two fatal defects in human perception: the audio discontinuity (audio break) and the out-of-synchronization (synchronization anomaly). In order to overcome these problems, a novel media synchronization model employed on multiple processes (or threads) in a multiprocessing environment is proposed. The problem of asynchronism due to system overload is solved by assigning a higher priority to more important media and adopting a delay-or-drop policy to treat the lower priority ones. Some experimental results are presented to show the effectiveness of the proposed model and the implementation mechanisms under a UNIX, X-Windows environment. On the basis of the proposed model, a continuous media playback (CMP) module, which acted as the key component of some popular multimedia systems such as multimedia authoring system, multimedia E-mail system, multimedia bulletin board system (BBS), and video-on-demand (VoD) System, was implemented.
Ruthenium Oxide Cathodes for Chlor-Alkali Electrolysis (2009)

Ruthenium oxide cathodes with low hydrogen overvoltage were manufactured by thermal decomposition method. Catalytic coating was comprised of ruthenium oxide and cerium oxide. Changes of crystalline structure and morphology of catalytic coating by electrolysis were observed. Mechanism of activation and stabilization of ruthenium oxide cathodes was investigated.
Gray's anatomy: Understanding uncertainty (2016)

We explore the key mechanisms whereby uncertainty impacts the business cycle by exploring the interaction of uncertainty with growth in industries with different technologies of production. We find that uncertainty shocks are particularly detrimental to growth in industries with rapid capital depreciation or high investment adjustment costs. The findings are consistent with real options theory: uncertainty leads firms to delay investment in new projects, but high depreciation and fixed costs of investment make delay more costly. On the other hand, we do not find evidence of a significant role of financial markets in the generation nor propagation of uncertainty shocks.
Seizures and brain injury in neonatal rats induced by 1S,3R-ACPD, a metabotropic glutamate receptor agonist (1993)

The role of metabotropic excitatory amino acid receptors in seizures and brain injury was examined using the selective metabotropic agonist 1S,3R-ACPD [(1S,3R)-1-aminocyclopentane-1-3-dicarboxylic acid] in 7-d-old neonatal rats. Systemic administration of 1S,3R-ACPD produced dose-dependent convulsions (ED50 = 16 mg/kg, i.p.) that were stereoselective for the active metabotropic ACPD isomer, since 1R,3S-ACPD was less potent (ED50 = 93 mg/kg, i.p.). 1S,3R-ACPD-induced seizures were antagonized by systemic administration of dantrolene, an inhibitor of intracellular calcium mobilization, but not by the ionotropic glutamate antagonists MK-801 or GYKI-52466. As indexed by hemispheric brain weight differences 5 d postinjection, unilateral intrastriatal injection of 1S,3R-ACPD (0.1-2.0 mumol/microliters), but not 1R,3S-ACPD, produced dose-dependent brain injury (maximal effect of 3.4 +/- 0.5% damage). 1S,3R-ACPD brain injury occurred in the absence of prominent behavioral convulsions. Histologic and ultrastructural examination of 1S,3R-ACPD-injected rat brains revealed swelling and degeneration of select neurons at 4 hr postinjection, but little evidence of injured neurons 5 d later. 1S,3R-ACPD-mediated brain injury was not attenuated by systemic administration of the NMDA antagonist MK-801 or the AMPA antagonist GYKI-52466. However, cointrastriatal injection of dantrolene reduced the severity of 1S,3R-ACPD injury by 88 +/- 7%. These studies indicate that seizures and neuronal injury can be elicited by the selective activation of metabotropic glutamate receptors in perinatal rats, and these effects of 1S,3R-ACPD involve the mobilization of intracellular calcium stores.
<i>In situ</i> manipulation and characterizations using nanomanipulators inside a field emission-scanning electron microscope (2003)

We have used two piezoelectric nanomanipulators to manage the multiwalled carbon nanotubes (MWCNTs) within the field emission-scanning electron microscope (FE-SEM). For an easy access of a tungsten tip to MWCNTs, we prepared the tungsten tip in sharp and long tip geometry using different electrochemical etching parameters. In addition, the sample stage was tilted by 45° from the normal direction of the surface to allow a better incident angle to the approaching tungsten tip. For manipulations, a nanotube or the bundles were attached at the tungsten tip using an electron beam-induced deposition (EBID). Using two manipulators, we have then fabricated a CNT-based transistor, a cross-junction of MWCNTs, and a CNT-attached atomic force microscopy tip. After these fabrications, the field emission properties of the MWCNT and junction properties of the MWCNT and the tungsten tip have been investigated. We found that the EBID approach was very useful to weld the nanostructured materials on the tungsten tip by simply irradiating the electron beam, although this sometimes increased the contact resistance by depositing hydrocarbon materials.