gebhart/patrepeval huggingface dataset:
DC, small-signal, and noise characteristics of 0.1 μm AlSb/InAs HEMTs (2002)

We report on the dc and small-signal characteristics of 0.1 /spl mu/m AlSb/InAs HEMTs. These recessed-gate devices have an In/sub 0.4/Al/sub 0.6/As/AlSb composite barrier above the InAs quantum well and a p/sup +/ GaSb layer within the AlSb buffer layer. The devices exhibit a transconductance of 600 mS/mm and an f/sub T/ of 120 GHz at V/sub DS/=0.6 V. An intrinsic f/sub T/ of 150 GHz is obtained after removal of the gate bonding pad capacitance. 0.5 /spl mu/m HEMTs on the same wafer exhibit a transconductance of 1 S/mm and an intrinsic f/sub T/Lg product of 50 GHz-/spl mu/m. At 4 GHz, the 0.1 /spl mu/m HEMTs have a minimum noise figure of 1 dB with 14 dB associated gain at V/sub DS/=0.4 V.
Reproducibility of measurements of regional resting and hyperemic myocardial blood flow assessed with PET. (1996)

MBF at rest can be measured reproducibly with 13N-ammonia PET. The individual response to pharmacologic stress appears to be relatively consistent. Thus, serial blood flow measurements with 13N-ammonia PET can be used to quantify the effect of various interventions on MBF and vasodilatory reserve.
Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology (2013)

Genome-wide association studies (GWAS) have identified a region upstream the BIN1 gene as the most important genetic susceptibility locus in Alzheimer's disease (AD) after APOE. We report that BIN1 transcript levels were increased in AD brains and identified a novel 3 bp insertion allele ∼28 kb upstream of BIN1, which increased (i) transcriptional activity in vitro, (ii) BIN1 expression levels in human brain and (iii) AD risk in three independent case-control cohorts (Meta-analysed Odds ratio of 1.20 (1.14-1.26) (P=3.8 × 10(-11))). Interestingly, decreased expression of the Drosophila BIN1 ortholog Amph suppressed Tau-mediated neurotoxicity in three different assays. Accordingly, Tau and BIN1 colocalized and interacted in human neuroblastoma cells and in mouse brain. Finally, the 3 bp insertion was associated with Tau but not Amyloid loads in AD brains. We propose that BIN1 mediates AD risk by modulating Tau pathology.
TDMA-based multi-hop resource reservation protocol for real-time applications in tactical mobile adhoc network (2010)

This paper proposes a new time division multiple access (TDMA) based multi-hop resource(slots) reservation protocol (TMRR) for tactical mobile adhoc networks (T-MANET). TMRR lets a node reserve the channel resource for multi-hop packet transmission in consecutive order, so that the packet transmission between a source node and a multi-hop away destination node is possible within a superframe. This paper evaluates the performance of the proposed protocol via OPNET simulation in terms of the average end-to-end delay and the average throughput in both static and mobile environments. And this paper compares it to that of the Evolutionary-TDMA (E-TDMA) which is a representative reservation-based medium access control (MAC) protocol considering node mobility in MANET. According to the simulation results of the single-hop scenarios, TMRR gives better packet throughput and delay performance than E-TDMA as the offered traffic is increased. For the multi-hop scenarios, the average end-to-end delay of TMRR nodes meets the multi-hop end-to-end delay requirements because a node can transmit the packets to a multi-hop away node within a superframe.
Embryo development in association with asymbiotic seed germination in vitro of Paphiopedilum armeniacum S. C. Chen et F. Y. Liu (2015)

This paper documents the key anatomical features during the development of P. armeniacum zygotic embryos and their ability to germinate asymbiotically in vitro. This study also examines the effect of media and seed pretreatments on seed germination and subsequent seedling growth. Seeds collected from pods 45 days after pollination (DAP) did not germinate while 95 DAP seeds displayed the highest seed germination percentage (96.2%). Most seedlings (50%) developed to stage 5 from 110 DAP seeds whose compact testa had not yet fully formed. Suspensor cells were vacuolated, which enabled the functional uptake of nutrients. The optimum basal medium for seed germination and subsequent protocorm development was eighth-strength Murashige and Skoog (1/8MS) for 95 DAP seeds and ¼MS for 110 DAP seeds. Poor germination was displayed by 140 DAP seeds with a compact testa. Pretreatment of dry mature seeds (180 DAP) with 1.0% sodium hypochlorite solution for 90 min or 40 kHz of ultrasound for 8 min improved germination percentage from 0 to 29.2% or to 19.7%, respectively. Plantlets that were at least 5 cm in height were transplanted to a Zhijing stone substrate for orchids, and 85.3% of plantlets survived 180 days after transplanting.
Clinical Features and Pharmacotherapy of Childhood Monoamine Neurotransmitter Disorders (2014)

Childhood neurotransmitter disorders are increasingly recognised as an expanding group of inherited neurometabolic syndromes. They are caused by disturbance in synthesis, metabolism, and homeostasis of the monoamine neurotransmitters, including the catecholamines (dopamine, norepinephrine, and epinephrine) and serotonin. Disturbances in monoamine neurotransmission will lead to neurological symptoms that often overlap with clinical features of other childhood neurological disorders (such as hypoxic ischaemic encephalopathy, cerebral palsy, other movement disorders, and paroxysmal conditions); consequently, neurotransmitter disorders are frequently misdiagnosed. The diagnosis of neurotransmitter disorders is made through detailed clinical assessment, analysis of cerebrospinal fluid neurotransmitters, and further supportive diagnostic investigations. Early and accurate diagnosis of neurotransmitter disorders is important, as many are amenable to therapeutic intervention. The principles of treatment for monoamine neurotransmitter disorders are mainly directly derived from understanding these metabolic pathways. In disorders characterized by enzyme deficiency, we aim to increase monoamine substrate availability, boost enzyme co-factor levels, reduce monoamine breakdown, and replace depleted levels of monoamines with pharmacological analogs as clinically indicated. Most monoamine neurotransmitter disorders lead to reduced levels of central dopamine and/or serotonin. Complete amelioration of motor symptoms is achievable in some disorders, such as Segawa's syndrome, and, in other conditions, significant improvement in quality of life can be attained with pharmacotherapy. In this review, we provide an overview of the clinical features and current treatment strategies for childhood monoamine neurotransmitter disorders.
Wavelet-based protection strategy for DC faults in multi-terminal VSC HVDC systems (2011)

A new protection algorithm for DC line faults in multi-terminal high voltage DC (MTDC) systems is proposed in this study. A four-terminal MTDC model is used to investigate fault behaviour and detection using the simulation program PSCAD/EMTDC. The simulation results are post-processed using Matlab. The fault clearing must be done very rapidly, to limit the effect of the fault on neighbouring DC lines because of the rapid increase in DC current. However, before clearing the line, the fault location must be detected as soon as possible. A rapid fault location detection algorithm is therefore needed, preferably without communication. The protection algorithm proposed in this study uses wavelet analysis to detect the fault location based on local measurements. The protection algorithm consists of three independent fault criteria, of which two use wavelet analysis. The third criterion is based on a detection method in the time domain. The latter is an additional detection method independent of wavelet analysis. Using a two out of three selection criteria results in an increased reliability of the whole protection algorithm. The final objective is to implement a protection algorithm which allows to detect a DC fault within 1 ms without using communication between the participating converter stations.
Neuroadrenergic dysfunction in obesity: an overview of the effects of weight loss (2010)

The autonomic dysfunction of obesity is reversible with weight loss, highlighting the importance of lifestyle intervention as a key therapeutic modality.
Synthesis, Characterization and Application of Nanostructured Porous Metal Oxides (2009)

Porous nanostructured materials have attracted much attention recently due to their potential application in the field of catalysis, sensing and adsorptions. General ways for the preparation of meso- and macro- porous structured single/mixed metal oxides have been developed in this work, including hydrothermal method to synthesize mesoporous transition metal oxides (TMOs) and self-rising approach to obtain macroporous TMOs.
DECISION TREE CONSTRUCTION AND COST-EFFECTIVENESS ANALYSIS OF TREATMENT OF ULCERATIVE COLITIS WITH PENTASA®MESALAZINE 2 G SACHET (2013)

The use of a single daily dose in the maintenance of remission is effective and related to higher patient compliance when compared to the multiple daily dose regimens, with lower costs.
A new method using Raman spectroscopy for in vivo targeted brain cancer tissue biopsy (2018)

Modern cancer diagnosis requires histological, molecular, and genomic tumor analyses. Tumor sampling is often achieved using a targeted needle biopsy approach. Targeting errors and cancer heterogeneity causing inaccurate sampling are important limitations of this blind technique leading to non-diagnostic or poor quality samples, and the need for repeated biopsies pose elevated patient risk. An optical technology that can analyze the molecular nature of the tissue prior to harvesting could improve cancer targeting and mitigate patient risk. Here we report on the design, development, and validation of an in situ intraoperative, label-free, cancer detection system based on high wavenumber Raman spectroscopy. This optical detection device was engineered into a commercially available biopsy system allowing tumor analysis prior to tissue harvesting without disrupting workflow. Using a dual validation approach we show that high wavenumber Raman spectroscopy can detect human dense cancer with >60% cancer cells in situ during surgery with a sensitivity and specificity of 80% and 90%, respectively. We also demonstrate for the first time the use of this system in a swine brain biopsy model. These studies set the stage for the clinical translation of this optical molecular imaging method for high yield and safe targeted biopsy.
A short leader sequence impairs the fidelity of initiation by eukaryotic ribosomes. (1991)

The functional consequences of unusually short 5' noncoding sequences on eukaryotic mRNAs are explored here by using an in vitro transcription and translation system. As the distance of the first AUG codon from the m7G cap was decreased from 32 to 3 nucleotides, the yield of protein initiated from the first AUG codon progressively decreased, with a corresponding increase in initiation from the second AUG codon. The leakiness attributable to a too-short leader sequence was offset, however, by introducing secondary structure downstream from the first AUG codon.
A control strategy of single-phase active filter using a novel d-q transformation (2004)

In this paper, a control strategy of the single-phase active filter using a novel d-q transformation is proposed. This d-q transformation is implemented by using Hilbert transform, by which the instantaneous single-phase voltage and current are converted into complex vectors (analytic signals) on the instantaneous basis. Since the fundamental components of voltages and currents are converted into DC components on the d-q coordinate both in the steady and transient states, the harmonics of voltages and currents can be obtained precisely through the low-pass filer installed on the d-q coordinate. This results in the economical active filter with a small capacitor suppressing the DC bus voltage fluctuation because the fundamental power can be fully removed from the active filter input.
Gel Electrophoretic Analysis of Corneal Collagen After Photodynamic Cross-linking Treatment (2008)

In the cross-linked corneas, a strong band of high-molecular-weight collagen polymers was shown as the biochemical correlate of the cross-linking effect, showing the efficiency of the new cross-linking procedure. This polymer band complies well with the morphologic correlate of an increased fiber diameter after cross-linking treatment. Its chemical stability supports hopes of a long-term effect of the new treatment.
Matrix Immobilization Enhances the Tissue Repair Activity of Growth Factor Gene Therapy Vectors (2001)

Although growth factor proteins display potent tissue repair activities, difficulty in sustaining localized therapeutic concentrations limits their therapeutic activity. We reasoned that enhanced histogenesis might be achieved by combining growth factor genes with biocompatible matrices capable of immobilizing vectors at delivery sites. When delivered to subcutaneously implanted sponges, a platelet-derived growth factor B-encoding adenovirus (AdPDGF-B) formulated in a collagen matrix enhanced granulation tissue deposition 3- to 4-fold (p < or = 0.0002), whereas vectors encoding fibroblast growth factor 2 or vascular endothelial growth factor promoted primarily angiogenic responses. By day 8 posttreatment of ischemic excisional wounds, collagen-formulated AdPDGF-B enhanced granulation tissue and epithelial areas up to 13- and 6-fold (p < 0.009), respectively, and wound closure up to 2-fold (p < 0.05). At longer times, complete healing without excessive scar formation was achieved. Collagen matrices were shown to retain both vector and transgene products within delivery sites, enabling the transduction and stimulation of infiltrating repair cells. Quantitative PCR and RT-PCR demonstrated both vector DNA and transgene mRNA within wound beds as late as 28 days posttreatment. By contrast, aqueous formulations allowed vector seepage from application sites, leading to PDGF-induced hyperplasia in surrounding tissues but not wound beds. Finally, repeated applications of PDGF-BB protein were required for neotissue induction approaching equivalence to a single application of collagen-immobilized AdPDGF-B, confirming the utility of this gene transfer approach. Overall, these studies demonstrate that immobilizing matrices enable the controlled delivery and activity of tissue promoting genes for the effective regeneration of injured tissues.
Design and characterization of a cleavage-resistant Annexin A1 mutant to control inflammation in the microvasculature (2010)

Human polymorphonuclear leukocytes adhesion to endothelial cells during the early stage of inflammation leads to cell surface externalization of Annexin A1 (AnxA1), an effector of endogenous anti-inflammation. The antiadhesive properties of AnxA1 become operative to finely tune polymorphonuclear leukocytes transmigration to the site of inflammation. Membrane bound proteinase 3 (PR3) plays a key role in this microenvironment by cleaving the N terminus bioactive domain of AnxA1. In the present study, we generated a PR3-resistant human recombinant AnxA1-named superAnxA1 (SAnxA1)-and tested its in vitro and in vivo properties in comparison to the parental protein. SAnxA1 bound and activated formyl peptide receptor 2 in a similar way as the parental protein, while showing a resistance to cleavage by recombinant PR3. SAnxA1 retained anti-inflammatory activities in the murine inflamed microcirculation (leukocyte adhesion being the readout) and in skin trafficking model. When longer-lasting models of inflammation were applied, SAnxA1 displayed stronger anti-inflammatory effect over time compared with the parental protein. Together these results indicate that AnxA1 cleavage is an important process during neutrophilic inflammation and that controlling the balance between AnxA1/PR3 activities might represent a promising avenue for the discovery of novel therapeutic approaches.
Editorial: Et maintenant, l'autre cohabitation... (1988)

Hauser Jacques. Editorial: Et maintenant, l'autre cohabitation.... In: Hommes et Migrations, n°1113, juin 1988. Et maintenant, l'autre cohabitation... pp. 2-3.
Separate sample logistic discrimination (1972)

The problem of discrimination when all or most of the observations are qualitative is discussed. The method of logistic discrimination introduced by Cox (1966) and Day & Kerridge (1967) is extended to the situation where separate samples are taken from each population, using the results of Aitchison & Silvey (1958) on constrained maximum likelihood estimation. The method is further extended to discrimination between three or more populations. The properties of logistic discrimination are investigated by simulation and the method is applied to the differential diagnosis of kerato-conjundivitis sicca.
THE EFFECT OF DISSOLVED KBr, KOH OR HCl ON THE RAMAN SPECTRUM OF WATER<sup>1</sup> (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTHE EFFECT OF DISSOLVED KBr, KOH OR HCl ON THE RAMAN SPECTRUM OF WATER1William R. Busing and Donald F. HornigCite this: J. Phys. Chem. 1961, 65, 2, 284–292Publication Date (Print):February 1, 1961Publication History Published online1 May 2002Published inissue 1 February 1961https://pubs.acs.org/doi/10.1021/j100820a024https://doi.org/10.1021/j100820a024research-articleACS PublicationsRequest reuse permissionsArticle Views771Altmetric-Citations134LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Toroidal Landau Damping - Theory and Physical Interpretation (1992)

Available from TIB Hannover: RA 71(4/253) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische Informationsbibliothek
Rifaximin: a nonabsorbed oral antibiotic. (2005)

Rifaximin is a rifamycin analogue with a broad spectrum of activity similar to that of rifampin; however, because it is poorly absorbed in the gastrointestinal tract, the focus of its development has been on intestinal infections and diseases. This agent has proven to be as effective as ciprofloxacin in treating travelers' diarrhea due to Escherichia coli, although it is ineffective in treating infections due to Campylobacter jejuni. Other potential uses for rifaximin in gastroenterologic disorders include treatment of hepatic encephalopathy, intestinal gas and gas-related symptoms, diverticular disease, intestinal bacterial overgrowth, pouchitis, ulcerative colitis, and active Crohn's disease. This article highlights several studies demonstrating the efficacy of rifaximin in treating travelers' diarrhea as well as other gastrointestinal diseases and discusses the drug's pharmacokinetics, indications, contraindications, warnings, precautions, adverse reactions, and dosing.
Jorro Beat (2015)

We present a shower-type tactile device, named "Jorro Beat". It enriches the music experience in the bathroom by providing tactile stimulation synchronized with music to a wide area of the skin by controlling the water flow of the shower. Our prototype device consists of a showerhead with a mechanical switch, a microcontroller, a motor driver, a DC motor and a cam that is connected to mechanical switch on the showerhead. We conducted an experiment to evaluate the performance of the device, namely bandwidth, latency and operating volume, and showed that the device has sufficient capacity for an enriching music experience, with up to 2100 beats per minute and around 54 dBA operating volume.
Stillbirths at the West Gonja hospital in northern Ghana (2016)

In most parts of Ghana, stillbirths (SBs) do not count in routine mortality data collection and there-fore are not seen as a major public health problem. The aim of this study was to determine still-birth rate, trend, causes and factors associated with stillbirth at the West Gonja Hospital in northern Ghana and offer recommendations. This study reviewed antenatal cards of mothers and records in the labour and maternity wards for cases of SBs from January 2009 to December 2013 for foetal and maternal characteristics. Data were entered and analyzed using SPSS software (version 18, Chicago). There were 3,641 births and 121 SBs during the study period with an average SBs rate of 33.2 per 1000 births. There was a gradual rise in the annual incidence of SBs from 2.9% in 2009 to 3.9% in 2012. Majority (55.4%) of the SBs were fresh. A total of 58 (47. 9%) of the SBs had no identifiable cause. The mean gestational age of SBs was 34.8 weeks (SD=4.2), and the mean weight was 2.4 Kg (SD=0.8). Majority (73.9%) of the mothers were housewives. We found strong positive associations between SBs and maternal occupation (p<0.00), but negatives associations with maturity of pregnancy (p= 0.01), mode of delivery (p<0.00), type of pregnancy (p=0.04) and the causes of stillbirths (p<0.00). This study found a high SBs rate of 33.2 per 1000 births, with a gradual rise in the incidence over the study period. Many of the SBs had no identifiable cause. Most of the mothers who had stillbirths were house wives and many of the cases had no identifiable causes. There is the need for improve SBs data collection and the need for further investigations on the causes of stillbirth in Ghana.Journal of Medical and Biomedical Sciences (2016) 5(1), 1-7Keywords: Mortality data, causes, incidence rate, parity, gestational week
Mapping parallel loops on multicore systems (2010)

The compute nodes in contemporary HPC systems contain one or more multicore processors. As a result, these nodes constitute a shared-memory multiprocessor, often combining CMP and SMT concurrency technologies. This configuration introduces different levels of sharing in the cache hierarchy, resulting in non-uniform data sharing overheads. In this paper we analyze the data-sharing patterns that exhibit a real multithreaded application when executing on a multicore system, with emphasis in the use of the shared last level cache (LLC) for the concurrent threads. As a consequence of this study, we explore the loop mapping problem in such systems with the aim of optimizing the shared use of the the LLC by all parallel threads. We propose a three-phase loop mapping strategy that deals with workload imbalances, minimizes cache sharing interferences, and maximizes intra-core and inter-core data reuse in the cache hierarchy. Preliminary results show some benefits of our approach. However, this is a work in progress and much more research is being done.