gebhart/patrepeval huggingface dataset:
Persistent Dystrophin Protein Restoration 90 Days after a Course of Intraperitoneally Administered Naked 2′OMePS AON and ZM2 NP-AON Complexes in mdx Mice (2012)

In Duchenne muscular dystrophy, the exon-skipping approach has obtained proof of concept in animal models, myogenic cell cultures, and following local and systemic administration in Duchenne patients. Indeed, we have previously demonstrated that low doses (7.5 mg/Kg/week) of 2'-O-methyl-phosphorothioate antisense oligoribonucleotides (AONs) adsorbed onto ZM2 nanoparticles provoke widespread dystrophin restoration 7 days after intraperitoneal treatment in mdx mice. In this study, we went on to test whether this dystrophin restoration was still measurable 90 days from the end of the same treatment. Interestingly, we found that both western blot and immunohistochemical analysis (up to 7% positive fibres) were still able to detect dystrophin protein in the skeletal muscles of ZM2-AON-treated mice at this time, and the level of exon-23 skipping could still be assessed by RT real-time PCR (up to 10% of skipping percentage). In contrast, the protein was undetectable by western blot analysis in the skeletal muscles of mdx mice treated with an identical dose of naked AON, and the percentage of dystrophin-positive fibres and exon-23 skipping were reminiscent of those of untreated mdx mice. Our data therefore demonstrate the long-term residual efficacy of this systemic low-dose treatment and confirm the protective effect nanoparticles exert on AON molecules.
Cyclodepsipeptides: A Rich Source of Biologically Active Compounds for Drug Research (2014)

Faced with the need to find new drugs for all kinds of diseases, science sees that Nature offers numerous classes of compounds showing an impressively high biological potential. Among those are the cyclodepsipeptides, hybrid structures composed of amino and hydroxy acids. In the past decades numerous cyclodepsipeptides have been isolated and their potential as drugs has been studied extensively. For several cyclodepsipeptides total syntheses both in solution and on solid-phase have been established, allowing the production of combinatorial libraries. In addition, the biosynthesis of specific cyclodepsipeptides has been elucidated and used for the chemoenzymatic preparation of nonnatural analogues. This review summarizes the recent literature on cyclic tetra- to decadepsipeptides, composed exclusively of α-amino- and α-hydroxy acids.
The importance of iron in long-term survival of maintenance hemodialysis patients treated with epoetin-alfa and intravenous iron: analysis of 9.5 years of prospectively collected data (2009)

Long term survival of maintenance hemodialysis patients was favorably affected by a relatively high hemoglobin level, by moderate intravenous iron administration, and by indicators of iron sufficiency. It was unfavorably influenced by a low hemoglobin level, and by indicators of iron deficiency.
Interaction of the Mycobacterial Heparin-Binding Hemagglutinin with Actin, as Evidenced by Single-Molecule Force Spectroscopy (2008)

Although Mycobacterium tuberculosis and related species are considered to be typical endosomal pathogens, recent studies have suggested that mycobacteria can be present in the cytoplasm of infected cells and cause cytoskeleton rearrangements, the mechanisms of which remain unknown. Here, we used single-molecule force spectroscopy to demonstrate that the heparin-binding hemagglutinin (HBHA), a surface adhesin from Mycobacterium tuberculosis displaying sequence similarities with actin-binding proteins, is able to bind to actin. Force curves recorded between actin and the coiled-coil, N-terminal domain of HBHA showed a bimodal distribution of binding forces reflecting the detection of single and double HBHA-actin interactions. Force curves obtained between actin and the lysine-rich C-terminal domain of HBHA showed a broader distribution of binding events, suggesting they originate primarily from intermolecular electrostatic bridges between cationic HBHA domains and anionic actin residues. We also explored the dynamics of the HBHA-actin interaction, showing that the binding force and binding frequency increased with the pulling speed and contact time, respectively. Taken together, our data indicate that HBHA is able to specifically bind actin, via both its N-terminal and C-terminal domains, strongly suggesting a role of the HBHA-actin interaction in the pathogenesis of mycobacterial diseases.
An Effective Lightweight Cryptographic Algorithm to Secure Resource-Constrained Devices (2018)

In recent years, small computing devices like embedded devices, wireless sensors, RFID tags (Radio Frequency Identification), Internet of Things (IoT) devices are increasing rapidly. They are expected to generate massive amount of sensitive data for controlling and monitoring purposes. But their resources and capabilities are limited. Those also work with valuable private data thus making security of those devices of paramount importance. Therefore, a secure encryption algorithm should be there to protect those vulnerable devices. Conventional encryption ciphers like RSA or AES are computationally expensive; require large memory but hinder performances of those devices. Simple encryption techniques, on the other hand are easy to crack, compromising security. In this paper a secure and efficient lightweight cryptographic algorithm for small computing devices has been proposed. It is a symmetric key block cipher, employing custom substitution-permutation (SP) network and a modified Feistel architecture. Two basic concepts from Genetic algorithm are used. A Linux based benchmark tool, FELICS is used for the measurement and MATLAB for the purpose of encryption quality testing. An improvement over the existing algorithm, the proposed algorithm reduces the use of processing cycles but at the same time provides sufficient security.
Physical and Chemical Properties of Hydroxyflavones. II. 3-Aroyl-5-hydroxyflavones. Synthetic and Infrared Spectral Studies<sup>1,2</sup> (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhysical and Chemical Properties of Hydroxyflavones. II. 3-Aroyl-5-hydroxyflavones. Synthetic and Infrared Spectral Studies1,2J. H. Looker and Walter W. HannemanCite this: J. Org. Chem. 1962, 27, 9, 3261–3263Publication Date (Print):September 1, 1962Publication History Published online1 May 2002Published inissue 1 September 1962https://pubs.acs.org/doi/10.1021/jo01056a067https://doi.org/10.1021/jo01056a067research-articleACS PublicationsRequest reuse permissionsArticle Views102Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
[Military activities of outpatient clinics to ensure the sanitary-epidemiological welfare of the population]. (2011)

The article describes the experience of the military outpatient institutions in providing sanitary-epidemiological welfare of the attached troops and medical staff. The list of activities implemented in practice of this trend is lead up, suggestions for the improvement are given.
Sphingomyelinase and cell-permeable ceramide analogs stimulate cellular proliferation in quiescent Swiss 3T3 fibroblasts. (1992)

Sphingomyelin Turnover and Cellular Proliferation chloride (79.3 Ci/mmol), and [y-3'P]ATP (3000 Ci/mmol) were purchased from Amersham Corp. Insulin and transferrin were from Collaborative Research (Lexington, MA).Sphingomyelinase (from brain, type HI), and DETAPAC' were from Sigma.Diacylglycerol Streptomyces sp. and Staphylococcus aureus), ceramides (from bovine kinase (from Escherichia coli) was from Lipidex, Inc. (Westfield, NJ).The various standard phospholipids and cardiolipin were from Avanti Polar Lipids.N-Hexanoylsphingosine
The SAS-3 delayed command system (1975)

To meet the requirements arising from the increased complexity of the power, attitude control and telemetry systems, a full redundant high-performance control section with delayed command capability was designed for the Small Astronomy Satellite-3 (SAS-3). The relay command system of SAS-3 is characterized by 56 bystate relay commands, with capability for handling up to 64 commands in future versions. The 'short' data command service of SAS-1 and SAS-2 consisting of shifting 24-bit words to two users was expanded to five users and augmented with a 'long load' data command service (up to 4080 bits) used to program the telemetry system and the delayed command subsystem. The inclusion of a delayed command service ensures a program of up to 30 relay or short data commands to be loaded for execution at designated times. The design and system operation of the SAS-3 command section are analyzed, with special attention given to the delayed command subsystem.
Phänomenologie, Semiotik und Bildbegriff: Eine kritische Diskussion (2011)

Dieser Beitrag diskutiert den phänomenologischen Bildbegriff von Lambert Wiesing. Zunächst wird dessen Position ausführlich präsentiert, um anschließend mit Hilfe der Semiotik und der Kommunikationswissenschaft die Schwachpunkte und (terminologischen) Probleme dieser Form der Bildtheorie aufzuzeigen. Aus dieser Diskussion heraus versucht der Aufsatz eine These zur Beantwortung der Frage »Was ist ein Bild?« zu entwickeln. Diese These besagt, dass die Wahrnehmung und das Erkennen eines Bildes (das als symbolisches Kommunikationsmedium begriffen wird) notwendig in der Rezeptionshaltung der Fiktionalität getätigt werden müssen. Das bedeutet, dass das »Wie« der bildlichen Darstellung den Betrachter dazu zwingt, dem erkannten Bildobjekt in einer »so-tun-als-ob«-Haltung gegenüberzutreten, um es als Bild zu erfassen. Obwohl der Betrachter weiß, dass die erkannte Bilddarstellung kein reales Objekt ist, spricht er so darüber, also ob es eines wäre, behandelt es aber nicht so. Das »Wie« des Bildobjekts determiniert also die Kommunikation und die Behandlung gegenüber der Darstellung des Bildes, oder anders ausgedrückt: Die Fiktionalitätsverweise eines Bildes führen den Bildbetrachter dahin, dass er das Bildobjekt wie einen fiktiven Gegenstand behandelt, auch wenn dies, wie z. B. bei einer Live- Schaltung im Fernsehen, keiner ist.
Functional Differentiation in the Leucine-Rich Repeat Domains of Closely Related Plant Virus-Resistance Proteins That Recognize Common Avr Proteins (2012)

The N' gene of Nicotiana sylvestris and L genes of Capsicum plants confer the resistance response accompanying the hypersensitive response (HR) elicited by tobamovirus coat proteins (CP) but with different viral specificities. Here, we report the identification of the N' gene. We amplified and cloned an N' candidate using polymerase chain reaction primers designed from L gene sequences. The N' candidate gene was a single 4143 base pairs fragment encoding a coiled-coil nucleotide-binding leucine-rich repeat (LRR)-type resistance protein of 1,380 amino acids. The candidate gene induced the HR in response to the coexpression of tobamovirus CP with the identical specificity as reported for N'. Analysis of N'-containing and tobamovirus-susceptible N. tabacum accessions supported the hypothesis that the candidate is the N' gene itself. Chimera analysis between N' and L(3) revealed that their LRR domains determine the spectrum of their tobamovirus CP recognition. Deletion and mutation analyses of N' and L(3) revealed that the conserved sequences in their C-terminal regions have important roles but contribute differentially to the recognition of common avirulence proteins. The results collectively suggest that Nicotiana N' and Capsicum L genes, which most likely evolved from a common ancestor, differentiated in their recognition specificity through changes in the structural requirements for LRR function.
Plant cell growth and differentiation may involve GAP regulation of Rac activity (1999)

Two Rac GTPase cDNAs, LjRac1 and LjRac2, were identified in the legume Lotus japonicus. Two-hybrid screening with dominant-constitutive mutations in the two Rac GTPases target three plant cDNAs, LjRacGAP1, LjRacGAP2 and LjRacGAP3, that encode putative GTPase activating proteins of Rho-GTPase subfamily members. Employing Rac antiserum, purified recombinant LjRac GTPases and recombinant LjRacGAP1, for ligand overlay assays, in vitro GAP affinity assays and GTPase activation, we confirmed that eukaryote Rac/RacGAP interplay is conserved in plants. In this investigation we have developed some tools that can be used to characterize the role of enhanced LjRac2 expression in developing root nodules.
Evaluating the Climate Benefits of CO<sub>2</sub>-Enhanced Oil Recovery Using Life Cycle Analysis (2015)

This study uses life cycle analysis (LCA) to evaluate the greenhouse gas (GHG) performance of carbon dioxide (CO2) enhanced oil recovery (EOR) systems. A detailed gate-to-gate LCA model of EOR was developed and incorporated into a cradle-to-grave boundary with a functional unit of 1 MJ of combusted gasoline. The cradle-to-grave model includes two sources of CO2: natural domes and anthropogenic (fossil power equipped with carbon capture). A critical parameter is the crude recovery ratio, which describes how much crude is recovered for a fixed amount of purchased CO2. When CO2 is sourced from a natural dome, increasing the crude recovery ratio decreases emissions, the opposite is true for anthropogenic CO2. When the CO2 is sourced from a power plant, the electricity coproduct is assumed to displace existing power. With anthropogenic CO2, increasing the crude recovery ratio reduces the amount of CO2 required, thereby reducing the amount of power displaced and the corresponding credit. Only the anthropogenic EOR cases result in emissions lower than conventionally produced crude. This is not specific to EOR, rather the fact that carbon-intensive electricity is being displaced with captured electricity, and the fuel produced from that system receives a credit for this displacement.
Automatic and transparent I/O optimization with storage integrated application runtime support (2015)

Traditionally storage has not been part of a programming model's semantics and is added only as an I/O library interface. As a result, programming models, languages, and storage systems are limited in the optimizations they can perform for I/O operations, as the semantics of the I/O library is typically at the level of transfers of blocks of uninterpreted bits, with no accompanying knowledge of how those bits are used by the application. For many HPC applications where I/O operations for analyzing and checkpointing large data sets are a non-negligible portion of the overall execution time, such a "know nothing" I/O design has negative performance implications.
Graphene-supported iron-based nanoparticles encapsulated in nitrogen-doped carbon as a synergistic catalyst for hydrogen evolution and oxygen reduction reactions (2014)

Electrolyzers and fuel cells have been extensively investigated as promising solutions for renewable energy storage and conversion. Hydrogen evolution reaction (HER) and oxygen reduction reaction (ORR) are important electrocatalytic processes in electrolyzers and fuel cells. Exploring efficient non-precious metal catalysts for HER and ORR in acidic medium remains a great challenge. Herein, we report that graphene-supported iron-based nanoparticles encapsulated in a nitrogen-doped carbon (Fe@N-C) hybrid material acts as an efficient HER and ORR catalyst. The hybrid material was synthesized by pyrolysis of graphene oxide and ammonia ferric citrate followed by acid-leaching. During the pyrolysis, nitrogen was doped into a graphene lattice, and the carbon nanoshell grown on graphene effectively suppressed the stacking of graphene sheets, exposing more active sites to reactants. The hybrid material showed higher electrocatalytic activities than graphene sheets or Fe@N-C alone, which is probably attributed to the synergetic role of nitrogen-doped graphene and Fe@N-C towards the electrocatalytic reactions.
<i>AMR1</i>, an Arabidopsis Gene That Coordinately and Negatively Regulates the Mannose/<scp>l</scp>-Galactose Ascorbic Acid Biosynthetic Pathway  (2009)

Ascorbic acid (AsA) biosynthesis in plants occurs through a complex, interconnected network with mannose (Man), myoinositol, and galacturonic acid as principal entry points. Regulation within and between pathways in the network is largely uncharacterized. A gene that regulates the Man/l-galactose (l-Gal) AsA pathway, AMR1 (for ascorbic acid mannose pathway regulator 1), was identified in an activation-tagged Arabidopsis (Arabidopsis thaliana) ozone-sensitive mutant that had 60% less leaf AsA than wild-type plants. In contrast, two independent T-DNA knockout lines disrupting AMR1 accumulated 2- to 3-fold greater foliar AsA and were more ozone tolerant than wild-type controls. Real-time reverse transcription-polymerase chain reaction analysis of steady-state transcripts of genes involved in AsA biosynthesis showed that AMR1 negatively affected the expression of GDP-Man pyrophosphorylase, GDP-l-Gal phosphorylase, l-Gal-1-phosphate phosphatase, GDP-Man-3',5'-epimerase, l-Gal dehydrogenase, and l-galactono-1,4-lactone dehydrogenase, early and late enzymes of the Man/l-Gal pathway to AsA. AMR1 expression appears to be developmentally and environmentally controlled. As leaves aged, AMR1 transcripts accumulated with a concomitant decrease in AsA. AMR1 transcripts also decreased with increased light intensity. Thus, AMR1 appears to play an important role in modulating AsA levels in Arabidopsis by regulating the expression of major pathway genes in response to developmental and environmental cues.
Sparse-Matrix support for the SkePU library for portable CPU/GPU programming (2016)

In this thesis work we have extended the SkePU framework by designing a new container data structure for the representation of generic two dimensional sparse matrices. Computation on matrices is an integral part of many scientific and engineering problems. Sometimes it is unnecessary to perform costly operations on zero entries of the matrix. If the number of zeroes is relatively large then a requirement for more efficient data structure arises. Beyond the sparse matrix representation, we propose an algorithm to judge the condition where computation on sparse matrices is more beneficial in terms of execution time for an ongoing computation and to adapt a matrix's state accordingly, which is the main concern of this thesis work. We present and implement an approach to switch automatically between two data container types dynamically inside the SkePU framework for a multi-core GPU-based heterogeneous system. The new sparse matrix data container supports all SkePU skeletons and nearly all SkePU operations. We provide compression and decompression algorithms from dense matrix to sparse matrix and vice versa on CPU and GPUs using SkePU data parallel skeletons. We have also implemented a context aware switching mechanism in order to switch between two data container types on the CPU or the GPU. A multi-state matrix representation, and selection on demand is also made possible. In order to evaluate and test effectiveness and efficiency of our extension to the SkePU framework, we have considered Matrix-Vector Multiplication as our benchmark program because iterative solvers like Conjugate Gradient and Generalized Minimum Residual use Sparse Matrix-Vector Multiplication as their basic operation. Through our benchmark program we have demonstrated adaptive switching between two data container types, implementation selection between CUDA and OpenMP, and converting the data structure depending on the density of non-zeroes in a matrix. Our experiments on GPU-based architectures show that our automatic switching mechanism adapts with the fastest SkePU implementation variant, and has a limited training cost.
Study on Dietary Habit and Effect of Onion Powder Supplementation on Serum Lipid Levels in Early Diagnosed Hyperlipidemic Patients (2008)

본 연구에서는 고지혈증 판정을 받은 40～50대 남성 14명에게 12주 동안의 양파가루 섭취가 고지혈증의 완화에 영향을 주는지 알아보기 위해 양파섭취 전과 후의 식이조사, 식생활조사, 식습관 조사 및 혈 중 지질의 변화를 비교 고찰하였다. 고지혈증 환자의 대부분이 식사 시에 ‘콜레스테롤’, ‘지방’을 주의한다고 하였다. 건강유지 방법으로는 주로 ‘운동’을 생각하고 있었다. 지방 식품의 섭취빈도는 ‘기름이 많은 고기 버터, 생크림’은 ‘1주일에 3～5일(12명)’, ‘계란노른자, 어육류 내장, 오징어’는 ‘1주일에 3～5일’(9명), ‘기름이 많은 음식, 마요네즈’는 1주일에 3～5일’(8명)로 나타났다. 열량영양소의 섭취비율은 고지혈증 치료지침에 비하여 당질은 낮게, 지방과 콜레스테롤은 다소 높게 섭취하고 있었다. 조사 요인들 간의 상관관계에서는 외식 빈도의 증가에 따라 알코올 섭취량이 증가하는 것(p＜0.01)으로, 알코올 섭취량은 BMI에도 영향을 주는 것으로 나타났다(p＜0.05). 운동의 경우 HDL-콜레스테롤에는 양의 상관성(p＜0.01)을, AI에는 음의 상관성(p＜0.05)을 보이면서 영향을 주었다. 양파가루 섭취 후의 건강의 느낌 변화 및 기대에서는 대부분의 환자들(12명)이 건강이 좋아질 것이라고 응답하였으며, 앞으로도 양파가루를 계속 섭취하겠다고 응답한 환자는 8명이었다. 양파가루 섭취로 환자의 체성분에서 어떤 유의적인 변화도 유발시키지 못하였다. 양파가루 섭취로 총 콜레스테롤(p＜0.01)과 LDL-콜레스테롤(p＜0.01) 및 동맥경화지수(p＜0.05)가 유의적으로 감소하였고, GOT와 GPT는 변화가 없었다. 본 연구에서는 양파가루의 보충 섭취가 고지혈증 환자들에서 혈중 지질수준과 동맥경화지수를 유의적으로 감소시키는 긍정적인 영향을 미치는 것으로 나타났다. 다만 비록 정상 범위의 값을 보이고 있었으나 중성지방의 농도가 유의적으로 증가한 것은 유의해야 할 점이며 앞으로 더 많은 연구가 요구된다. 본 연구에서는 일부 환자들만을 상대로 12주간의 중재기간을 통한 실험을 하였으나 짧은 기간이었고, 위약군을 실시하지 못하여 양파의 충분한 효과를 논하기에는 부족한 점이 분명히 있다. 다만 다른 식생활의 변화나 약물의 사용 없이 양파가루의 섭취만으로 혈중 지질 값이 유의적으로 감소한 것은 양파의 기능성식품으로서의 가능성은 보여준 것으로 생각된다. 앞으로 더 많은 실험대상자들을 상대로 대조군과 실험군의 비교를 통한 장기간의 임상실험을 통하여 좀 더 깊이 있는 연구가 이루어져야 할 것이다.
The dopamine D2 receptor (DRD2) gene: a genetic risk factor in smoking (1996)

Of a group of 312 non-Hispanic Caucasians who smoked at least one pack per day, had unsuccessfully attempted to stop smoking, and were free of alcohol or other drug dependence, 48.7% carried the A1 allele of the DRD2 gene. This was significantly greater than the 25.9% prevalence in the 714 known non-Hispanic Caucasian controls without alcohol or drug abuse, p < 10(-8), and significantly greater than in a smaller set of our study controls. There was a significant, inverse relationship between the prevalence of the D2A1 allele and the age of onset of smoking, p = 0.02, and the maximum duration of time the smokers had been able to quit smoking on their own, p = 0.02. These results suggest the DRD2 gene is one of a multifactorial set of risk factors associated with smoking.
Sleep dysfunction in Parkinson's disease. (1998)

The frequency of sleep complaints in patients with Parkinson's disease (PD) is estimated to be between 60-90% and a variety of either disease-related or secondary mechanisms and the dopaminergic treatment itself contributes to the development of different sleep disturbances. These comprise slight, fragmented sleep with increased number of arousals and awakenings, and PD-specific motor phenomena such as nocturnal immobility, rest tremor, eye-blinking, dyskinesias, and other phenomena such as periodic and nonperiodic limb movements in sleep, restless legs syndrome, fragmentary myoclonus, and respiratory dysfunction in sleep. Depression and hallucinations/psychosis further complicate the picture. The incidence of REM sleep behavior disorder (RBD) with nightmares and violent behavior is increased in PD and may occur as a preclinical disease-related symptom. A careful sleep history of patients and their partners, polysomnograms when necessary, motor and psychiatric assessments should precede individual treatment strategies, which include adjusting dopaminergic daytime treatment, benzodiazepines for RBD, reduction of anticholinergic drugs, and, if necessary, clozapine for nocturnal psychosis.