gebhart/patrepeval huggingface dataset:
Three-dimensional multichannel Si microprobe electrode array chip for analysis of the nervous system (2004)

This paper reports on a sensor chip device including a needle-like penetrating microprobe electrode array for simultaneous analysis of neurons in tissue. The probe array was fabricated on a Si substrate by selective epitaxial Si growth, is a few microns in diameter similar to the dimensions of the neurons with low invasiveness and low tissue damage. Using standard IC process followed by the probe growth, the probe array can be fabricated on IC signal processors improving the performance of the electrode chip. Neural signals were recorded from a carp retina with the Si microprobes.
Digital Predistortion Using Lookup Tables With Linear Interpolation and Extrapolation: Direct Least Squares Coefficient Adaptation (2016)

In this paper, we present a method to implement digital predistortion (DPD) memory models using lookup tables (LUTs) with linear interpolation and extrapolation. We introduce the required set of basis functions to describe this model. The DPD output is expressed as a linear combination of these basis functions and we show how to directly estimate the LUT entries using least squares. We show how this model achieves lower complexity at similar or better performance compared to polynomial models translated to LUTs with interpolation or models based on LUTs without interpolation whose coefficients are adapted directly. We refer to this model as the direct adaptation of LUTs with interpolation/extrapolation (DLUTI). In this paper we also introduce the composite memory polynomial model: a new polynomial model which is a hybrid between the generalized memory polynomial and the dynamic deviation reduction models. This model is used as a starting point to generate the final LUT-based model.
Voltage-induced color-selective absorption with surface plasmons (1995)

A phenomenon of voltage-induced color-selective absorption at metal/liquid crystal interface with surface plasmons is reported. When a white light is incident at a metal/liquid crystal interface, those photons in surface plasmon resonance frequency range are totally absorbed and the reflected light shows the complementary color. If a voltage is used to change the refraction index of the liquid crystal, then the surface plasmon resonance frequency will change, and the reflected light will also show the color change. The reflectance spectrum is calculated from a well-known solution to the boundary value problem in optics. Good agreement with the observations is obtained. This phenomenon could lead to a new generation of display devices.
Hierarchically nanotextured surfaces maintaining superhydrophobicity under severely adverse conditions (2014)

Superhydrophobic surfaces are highly desirable for a broad range of technologies and products affecting everyday life. Despite significant progress in recent years in understanding the principles of hydrophobicity, mostly inspired by surface designs found in nature, many man-made surfaces employ readily processable materials, ideal to demonstrate principles, but with little chance of survivability outside a very limited range of well-controlled environments. Here we focus on the rational development of robust, hierarchically nanostructured, environmentally friendly, metal-based (aluminum) superhydrophobic surfaces, which maintain their performance under severely adverse conditions. Based on their functionality, we superpose selected hydrophobic layers (i.e. self-assembled monolayers, thin films, or nanofibrous coatings) on hierarchically textured aluminum surfaces, collectively imparting high level robustness of superhydrophobicity under adverse conditions. These surfaces simultaneously exhibit chemical stability, mechanical durability and droplet impalement resistance. They impressively maintained their superhydrophobicity after exposure to severely adverse chemical environments like strong alkaline (pH ∼ 9-10), acidic (pH ∼ 2-3), and ionic solutions (3.5 weight% of sodium chloride), and could simultaneously resist water droplet impalement up to an impact velocity of 3.2 m s(-1) as well as withstand standard mechanical durability tests.
Network-in-a-box: how to set up a secure wireless network in under a minute (2004)

Combining effective security and usability is often considered impossible. For example, deploying effective security for wireless networks is a difficult task, even for skilled systems administrators -- a fact that is impeding the deployment of many mobile systems.
OPTIMALITY AND OPPOSED HANDSHAPES IN TAIWAN SIGN LANGUAGE (2000)

This paper provides a linguistic account of opposed handshapes in Taiwan Sign Language (TSL). Examination of TSL opposed handshapes reveals that not all of the 29 logically possible opposed handshape types are attested. Of the ones that are attested, they differ (often drastically) in frequency of occurrence. We provide an analys is of the statistical data using Optimality Theory, showing that the various attested frequencies of opposed handshapes are systematic. The implications of this study for language change and acquisition are explored.
Suppression of Noxious Stimulus-Evoked Activity in the Ventral Posterolateral Nucleus of the Thalamus by a Cannabinoid Agonist: Correlation between Electrophysiological and Antinociceptive Effects (1996)

The CNS contains a putative cannabinergic neurotransmitter and an abundance of G-protein-coupled cannabinoid receptors. However, little is known about the function of this novel neurochemical system. Cannabinold agonists produce antinociception in behavioral tests, suggesting the possibility that this system serves in part to modulate pain sensitivity. To explore this possibility, the effects of the cannabinoid agonist WIN 55,212-2 on nociceptive neurons in the ventroposterolateral (VPL) nucleus of the thalamus were examined in urethane-anesthetized rats. After identification of a nociresponsive neuron, a computer-controlled device delivered graded pressure stimuli to the contralateral hindpaw. WIN 55,212-2 (0.0625, 0.125, and 0.25 mg/kg, i.v.) suppressed noxious stimulus-evoked activity of VPL neurons in a dose-dependent and reversible manner. Noxious stimulus-evoked firing was affected more than spontaneous firing. These effects were apparently mediated by cannabinoid receptors, because the cannabinoid receptor-inactive enantiomer of the drug (WIN 55,212-3, 0.25 mg/kg) failed to alter the activity of this population of cells. Administration of morphine (0.5 mg/kg, i.v.) produced effects that were very similar to those produced by the cannabinoid. WIN 55,212-2 (0.25 mg/kg, i.v.) failed to alter the responses of non-nociceptive low-threshold mechanosensitive neurons in the VPL WIN 55,212-2 produced antinociceptive effects with a potency and time course similar to that observed in the electrophysiological experiments, despite the differences in the anesthetic states of the animals used in these experiments. The antinociceptive and electrophysiological effects on VPL neurons outlasted the motor effects of the drug. Furthermore, the changes in nociceptive responding could not be attributed to changes in skin temperature. Taken together, these findings suggest that cannabinoids decrease nociceptive neurotransmission at the level of the thalamus and that one function of endogenous cannabinoids may be to modulate pain sensitivity.
Altura de extracción de la muestra para evaluación de densidad básica y blancura en madera de Salix sp. (2005)

The aim of the present work was to find the optimum sampling point representative for the whole tree, for basic density and brightness evaluation, in two Salix clones growing in two different sites of Delta of Paran, Argentina. Thirty-two trees were sampled, aged 8 to 13 years old. Disks were taken at three heights, called "predictive sections" (1.30 m, 25% and 65% of commercial height). Radial variation was studied by sampling each wood disk in two opposite cardinal directions at three points of the radius (33%, 66% and 100% of its length), amounting to 18 sampling positions in each tree. The parameter estimation of the whole tree and predictive sections was calculated as weighted mean values. The relationship between whole tree and predictive sections values was quantified using linear regression analysis. The breast height (1.30 m) was the best level for predicting American willow mean basic density and hybrid willow mean brightness of the whole tree, when the fittings obtained were considered. The 25% and 65% of commercial height were the most appropriate levels for predicting mean brightness in the hybrid and mean basic density in the American clone, respectively.
Corrosion of Carbon Steel and Alloys in Concentrated Ammonium Chloride Solutions (2012)

Corrosion resistance and the behavior of carbon steel and alloys in high concentration ammonium chloride (NH4Cl) solutions were investigated. This study was conducted to better understand material performance in severe NH4Cl corrosive environments in refineries. Immersion tests were performed under boiling 20 wt% and 40 wt% NH4Cl solutions. Sixteen materials commonly used in refineries and two new alloys were examined, including carbon steel; aluminized carbon steel; aluminum brass; Types 405, 410, 304L, 316L, and 321 stainless steels (UNS S40500, S41000, S30403, S31603, and S32100); 300-series stainless steel with 6% Mo; two types of super duplex stainless steels; Alloys 800, 625, and C-276 (UNS N08800, N06625, and N10276); Grade 2 and Grade 19 titanium (UNS R50400 and R53530); Alloy A (equivalent to a modified Type 317L [UNS S31703] stainless steel); and a modified Alloy 825 (UNS N06845). Significant corrosion was observed in carbon steel in both solutions. The corrosion rates of carbon steel were as high as 25.4 mm/y and 60.4 mm/y in 20 wt% and 40 wt% NH4Cl solutions, respectively. However, neither general corrosion nor pitting was observed on titanium alloys and alloys with a pitting resistant equivalent number (PREN) of 40 and higher. The maximum pit depth had a close relationship with the PREN. In addition, an electrochemical study was used to investigate the corrosion behavior of carbon steel. The effects of the temperature and NH4Cl concentration were determined from polarization curves and the corrosion potential.
Further SAR in the new antitumor 1-amino-substituted gamma-carbolines and 5H-benzo[e]pyrido[4,3-b]indoles series. (1992)

Using previously described techniques, various new 1-amino-substituted 5H-pyrido[4,3-b]indoles (gamma-carbolines, gamma-C) and 5H-benzo[e]pyrido[4,3-b]indoles (BPI) have been synthesized and evaluated. For known compounds containing a 1-[(dimethylamino)propyl] group, 1a and 1b in the gamma-C series and 2 in the BPI series are the most active. Studies with newly synthesized derivatives show that: (i) in the gamma-C series, the 4-unsubstituted-8-hydroxy-compound was inactive, whereas the 4-unsubstituted-9-hydroxy-5H-benzo[e]pyrido[4,3-b]indole is active; (ii) the 4-ethyl-8-hydroxy-5H-pyrido[4,3-b]indole derivative retains antitumor properties, but the 1-amino-substituted 4-ethyl-9-hydroxy-5H-benzo[e]pyrido[4,3-b]indole analog is devoid of biological activity; (iii) in the 5H-benzo[e]pyrido[4,3-b]indole series, the displacement of a hydroxyl group from the 9- to 10-position leads to inactive compounds. Based on the structural analogies, these results were unexpected because the same substituents on the 4-position lead to different biological properties in the two series.
Electrolyte Films in Acid Copper Plating Baths (1940)

A method of sampling the film of electrolyte immediately adjacent to a plating electrode has been developed. A small hole was drilled through the electrode, and electrolyte slowly siphoned through this hole while the plating operation was in progress. Experimental results are presented for the acid copper sulfate plating bath. The copper decrease and acid increase in the cathode film were studied under various conditions of current density, copper concentration, acid concentration and temperature. Variations in acid concentration were found to affect the film more than changes in copper concentration. An increase in temperature markedly decreases the difference between the film and main body concentrations. The ratio of copper to acid in the film has been considered, and the results interpreted from this point of view. The effect of the location of the sampling hole on the electrode on the composition of the film was also studied. On moving the sampling hole horizontally from the middle to the edge of the electrode, little difference in the composition of the film was noted. Large differences in the film composition were found when the samples were taken from the bottom, middle and top of the electrode, even though the electrolyte was sufficiently well stirred to avoid stratification.
Simulation of a Doppler lidar system for autonomous navigation and hazard avoidance during planetary landing (2016)

The latest mission proposals for exploration of solar system bodies require accurate position and velocity data during the descent phase in order to ensure safe, soft landing at the pre-designated sites. During landing maneuvers, the accuracy of the on-board inertial measurement unit (IMU) may not be reliable due to drift over extended travel times to destinations. NASA has proposed an advanced Doppler lidar system with multiple beams that can be used to accurately determine attitude and position of the landing vehicle during descent, and to detect hazards that might exist in the landing area. In order to assess the effectiveness of such a Doppler lidar landing system, it is valuable to simulate the system with different beam numbers and configurations. In addition, the effectiveness of the system to detect and map potential landing hazards must be understood. This paper reports the simulated system performance for a proposed multi-beam Doppler lidar using the LadarSIM system simulation software. Details of the simulation methods are given, as well as lidar performance parameters such as range and velocity accuracy, detection and false alarm rates, and examples of the Doppler lidars ability to detect and characterize simulated hazards in the landing site. The simulation includes modulated pulse generation and coherent detection methods, beam footprint simulation, beam scanning, and interaction with terrain.
Multiphoton microscopy with clearing for three dimensional histology of kidney biopsies (2016)

We present a multiphoton microscopy approach with clearing optimized for pathology evaluation producing image quality comparable to traditional histology. Use of benzyl alcohol/benzyl benzoate with 4',6-diamidino-2-phenylindole and eosin in an optimized imaging setup results in optical sections nearly indistinguishable from traditionally-cut sections. Application to human renal tissue demonstrates diagnostic-level image quality can be maintained through 1 millimeter of tissue. Three dimensional perspectives reveal changes of glomerular capsule cells not evident on single sections. Collagen-derived second harmonic generation can be visualized through entire biopsies. Multiphoton microscopy with clearing has potential for increasing the yield of histologic evaluation of biopsy specimens.
Differential effects of omega-conotoxin GVIA, nimodipine, calmidazolium and KN-62 injected intrathecally on the antinociception induced by beta-endorphin, morphine and [D-Ala2,N-MePhe4,Gly-ol5]-enkephalin administered intracerebroventricularly in the mouse. (1997)

We previously reported that beta-endorphin and morphine administered supraspinally produce antinociception by activating different descending pain-inhibitory systems. To determine the role of spinal calcium channels, calmodulin and calcium/calmodulin-dependent protein kinase II in the production of antinociception induced by morphine, [D-Ala2,N-MePhe4,Gly-ol5]-enkephalin (DAMGO) or beta-endorphin administered supraspinally, the effects of nimodipine (an L-type calcium channel blocker), omega-conotoxin GVIA (an N-type voltage-dependent calcium channel blocker), calmidazolium (a calmodulin antagonist) or KN-62 (a calcium/calmodulin-dependent protein kinase II inhibitor) injected intrathecally (i.t.) on the antinociception induced by morphine, DAMGO or beta-endorphin administered intracerebroventricularly (i.c.v.) were examined in the present study. Antinociception was assessed by the mouse tail-flick test. The i.t. injection of nimodipine (from 0.024 to 2.4 pmol), omega-conotoxin GVIA (from 0.0033 to 0.33 pmol), calmidazolium (from 0.0015 to 0.15 pmol) or KN-62 (from 0.0014 to 0.14 pmol) alone did not affect the basal tail-flick latencies. The i.t. pretreatment of mice with nimodipine, omega-conotoxin GVIA, calmidazolium or KN-62 dose dependently attenuated the inhibition of the tail-flick response induced by beta-endorphin administered i.c.v. However, the inhibition of the tail-flick response induced by morphine or DAMGO administered i.c.v. was not changed by i.t. pretreatment with nimodipine, omega-conotoxin GVIA, calmidazolium or KN-62. The results suggest that spinally located L- and N-type calcium channels, calmodulin and calcium/calmodulin-dependent protein kinase II may be involved in the modulation of antinociception induced by beta-endorphin, but not morphine and DAMGO, administered supraspinally.
METALLIC GALLIUM-PROMOTED REFORMATSKY-TYPE REACTION (1996)

ＭＥＴＡＬＬＩＣ ＧＡＬＬＩＵＭ－ＰＲＯＭＯＴＥＤ ＲＥＦＯＲＭＡＴＳＫＹ－ＴＹＰＥ ＲＥＡＣＴＩＯＮＭＥＴＡＬＬＩＣＧＡＬＬＩＵＭ－ＰＲＯＭＯＴＥＤＲＥＦＯＲＭＡＴＳＫＹ－ＴＹＰＥＲＥＡＣＴＩＯＮ￥ＹｉｎｇＨＡＮ；ＺｈｅｎｇＦａＣＨＩ；ａｎｄＹａｏ...
The Statistical Analysis of Enzyme Kinetic Data (1967)

Introduction Statistical Analysis Experimental Design and Evaluation of Results FORTRAN Programs for Fitting Enzyme Kinetic Data Experimental Applications to Date
Mechanisms of Human Lymphocyte Migration and their Role in the Pathogenesis of Disease (1989)

Lymphocyte recirculation is an essential component of the functional immune system, providing a means for constant surveillance of the organism's tissues by immunocompetent cells and, moreover, facilitating interactions between different cell types engaged in the immune response. Adhesive interactions between recirculating lymphocytes and the wall of high endothelial venules (HEV) are thought to play a central role in this process. These interactions are mediated by lymphocyte homing receptors expressed on the lymphocyte cell surface which recognize tissue-specific molecules on the endothelium. Moreover, LFA-1 is also involved in the regulation of lymphocyte traffic. In addition, recent evidence indicating that these mechanisms may also play a role in the pathogenesis of chronic inflammatory diseases and non-Hodgkin's lymphomas is discussed.
Expression of the Niacin Receptor GPR109A in Retina: More than Meets the Eye? (2013)

GPR109A was discovered recently as the G-protein coupled receptor for niacin (nicotinic acid), a drug used widely in the treatment of hyperlipidemia. Upon its initial discovery, expression of the receptor was thought to be restricted primarily to adipocytes and immune cells (monocytes/macrophages), a pattern of localization consistent with the known actions of niacin -anti-lipolytic and anti-atherogenic. Of late however, several new reports have arisen detailing expression of the receptor in other cell and tissue types. Interestingly, with the exception of dermal Langerhans cells, the cells responsible for skin flushing, an unwanted side effect of high-dose niacin therapy, the function of the receptor in the additional cell types described is largely anti-inflammatory in nature. The receptor might also have a role in cancer; silencing of the receptor has been reported in colon and breast cancers, and forced expression of the receptor in tumor cells induces apoptosis, thereby suggesting a tumor-suppressive role for the receptor. This supports strongly not only the critical importance of GPR109A expression and activity under normal, basal conditions, but also the strength in impact that therapies capable of augmenting or optimizing its expression and activation may have in thwarting the development and progression of inflammation and cancer. Given the key causative role of inflammation in diabetic retinopathy, and the critical lack of viable strategies for intervening early in this pathology, new therapies, particularly those targeting inflammation, are sorely needed. Herein, we describe preclinical and clinical studies documenting the expression of GPR109A, the pleiotropic effects elicited in response to its activation and the underlying mechanisms to explain these actions. This information we discuss in the context of its relevance to diabetic retina, ultimately providing insight into strategy for future targeting of the receptor and development of new therapies for prevention and treatment of retinopathy in diabetes.
Autonomous image localization for visual inspection of civil infrastructure (2017)

Low-cost, high-performance vision sensors in conjunction with aerial sensing platforms are providing new possibilities for achieving autonomous visual inspection in civil engineering structures. A large volume of images of a given structure can readily be collected for use in visual inspection, overcoming spatial and temporal limitations associated with human-based inspection. Although researchers have explored several algorithms and techniques for vision-based inspection in recent decades, a major challenge in past implementations lies in dealing with a high volume of images while only a small fraction of them are important for actual inspection. Because processing irrelevant images can generate a significant number of false-positives, automated visual inspection techniques should be used in coordination with methods to localize relevant regions on the images. When combined, automated visual inspection will be able to meet the objectives and quality of human visual inspection. To enable this technology, we develop and validate a novel automated image localization technique to extract regions of interest (ROIs) on each of the images before utilizing vision-based damage detection techniques. ROIs are the portions of an image that contain the physical region of the structure that is targeted for visual interrogation, denoted as the targeted region of interest (TRI). ROIs are computed based on the geometric relationship between the collected images and the TRIs. Analysis of such highly relevant and localized images would enable efficient and reliable visual inspection. We successfully demonstrate the capability of the technique to extract the ROIs using a full-scale highway sign structure in the case where weld connections serve as the TRIs.
Effective on-chip inductance modeling for multiple signal lines and application to repeater insertion (2002)

/sup A/ new approach to handle inductance effects for multiple signal lines is presented. The worst-case switching pattern is first identified. Then a numerical approach is used to model the effective loop inductance (L/sub eff/) for multiple lines. Based on a look-up table for L/sub eff/, an equivalent single line model can be generated to decouple a specific signal line from the others to perform static timing analysis. Compared to the use of full RLC netlists for multiple lines, this approach greatly improves the computational efficiency and maintains accuracy for timing and signal integrity analysis. We apply these models to repeater insertion in critical paths and find that, for a single line, the RLC model minimizes delay with fewer number of repeaters than RC model. However, for multiple lines, we find that same number of repeaters is inserted for optimal delay according to both the RC and RLC models.
Broadband Terahertz Wave Deflection Based on C‐shape Complex Metamaterials with Phase Discontinuities (2013)

A broadband terahertz wave deflector based on metasurface induced phase discontinuities is reported. Various frequency components ranging from 0.43 to 1.0 THz with polarization orthogonal to the incidence are deflected into a broad range of angles from 25° to 84°. A Fresnel zone plate consequently developed from the beam deflector is capable of focusing a broadband terahertz radiation.