gebhart/patrepeval huggingface dataset:
Природа времени и человек (2016)

The article examines the nature of time and relationship human and time on the Kantian position and modern physical basic. There are made the conclusion of the moral and aesthetic essence of time, the immanence of the good in time. There are compare the classical and post-modern understanding of time, analyzed different concepts of time. In the article human understand like a moral and free thing, personality and individuality (like understand human by German philosopher Kant).
Cardiovascular pharmacology. II: The use of catecholamines, pressor agents, digitalis, and corticosteroids in CPR and emergency cardiac care. (1986)

The Cardiovascular Pharmacology II panel met during the AHA National Conference on Standards and Guidelines for CPR and emergency cardiac care to consider the use of catecholamines, pressor agents, digitalis, and corticosteroids during advanced cardiac life support. During cardiac arrest, catecholamines and pressor agents have been shown to improve the rate of success of resuscitation. The useful properties of these drugs are mediated by strong alpha-adrenergic stimulation resulting in improved coronary perfusion. beta-Adrenergic stimulation during cardiac arrest is unimportant for resuscitation and potentially harmful. Studies have not demonstrated a difference between mixed agonists and alpha-agonists with respect to overall outcome. Consequently, the panel recommended that epinephrine continue to be the primary vasopressor for use during cardiac arrest. For cardiovascular support in the hemodynamically unstable patient, the panel recommended that drugs be chosen for specific pharmacologic actions that will allow the needed physiologic manipulation guided by objective hemodynamic measurements. The panel found that digitalis preparations and corticosteroids have very limited use in emergency cardiac care.
The Last Phase of Nestorian History (1959)

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Photochromic polyurethanes for rewritable CGHs in optical testing (2011)

The development of photochromic Computer Generated Holograms (CGHs) to test any complex optics, such as aspheres and free-form optics, is described. A thermally irreversible photochromic polyurethane has been synthesized to give good thin films with a strong modulation of the optical transmission. The photochromic CGH has been tested with a simple interferometrical configuration showing promising results. The use of photochromic CGHs provides advantages over standard technologies, as rewritability and self developing.
Single crystal silicon thin film transistors fabricatedat low process temperatureson glass substrates (1996)

Thin film transistors were fabricated in single crystal silicon films bonded to glass substrates. High electron mobilities were achieved, making integration of the driving circuitry and pixel switching elements on the same glass substrate possible and allowing improved display aperture ratios. These single crystal silicon TFTS are attractive for AMLCD applications.
Poly I:C-Induced Tumor Cell Apoptosis Mediated by Pattern-Recognition Receptors (2012)

Poly I:C is a synthetic dsRNA that can imitate a viral infection and elicit host immune responses by triggering specific pattern-recognition receptors (PRRs) such as toll-like receptor 3 and retinoic acid inducible gene I(RIG-I)-like receptors, including RIG-I and melanoma differentiation-associated gene 5. Activation of these PRRs by poly I:C triggers a signal transduction cascade that results in the activation of NF-κB and production of type I interferon. Poly I:C has been used as a vaccine adjuvant for cancer immunotherapy for several decades. Evidence from recent studies indicates that poly I:C can directly induce apoptosis in several types of tumor cells, thus providing a new therapeutic approach for cancer treatment. However, the molecular mechanism underlying the induction of apoptosis by poly I:C is still unclear. In this review, we summarize the current knowledge of poly I:C-induced tumor cell apoptosis, focusing on the key molecules and pathways involved in this process.
The founder mutations 185delAG and 5382insC in BRCA1 and 6174delT in BRCA2 appear in 60% of ovarian cancer and 30% of early-onset breast cancer patients among Ashkenazi women. (1997)

The mutations 185delAG, 188del11, and 5382insC in the BRCA1 gene and 6174delT in the BRCA2 gene were analyzed in 199 Ashkenazi and 44 non-Ashkenazi Jewish unrelated patients with breast and/or ovarian cancer. Of the Jewish Ashkenazi women with ovarian cancer, 62% (13/21) had one of the target mutations, as did 30% (13/43) of women with breast cancer alone diagnosed before the age 40 years and 10% (15/141) of those with breast cancer diagnosed after the age 40 years. Age at ovarian cancer diagnosis was not associated with carrier status. Of 99 Ashkenazi patients with no family history of breast and/or ovarian cancer, 10% carried one of the mutations; in two of them the mutation was proved to be paternally transmitted. One non-Ashkenazi Jewish ovarian cancer patient from Iraq carried the 185delAG mutation. Individual mutation frequencies among breast cancer Ashkenazi patients were 6.7% for 185delAG, 2.2% for 5382insC, and 4.5% for 6174delT, among ovarian cancer patients; 185delAG and 6174delT were about equally common (33% and 29%, respectively), but no ovarian cancer patient carried the 5382insC. More mutations responsible for inherited breast and ovarian cancer probably remain to be found in this population, since 79% of high-incidence breast cancer families and 35% of high-incidence breast/ovarian cancer families had none of the three known founder mutations.
Do as eye say: Gaze cueing and language in a real-world social interaction (2013)

Gaze cues are important in communication. In social interactions gaze cues usually occur with spoken language, yet most previous research has used artificial paradigms without dialogue. The present study investigates the interaction between gaze and language using a real-world paradigm. Each participant followed instructions to build a series of abstract structures out of building blocks, while their eye movements were recorded. The instructor varied the specificity of the instructions (unambiguous or ambiguous) and the presence of gaze cues (present or absent) between participants. Fixations to the blocks were recorded and task performance was measured. The presence of gaze cues led to more accurate performance, more accurate visual selection of the target block and more fixations towards the instructor when ambiguous instructions were given, but not when unambiguous instructions were given. We conclude that people only utilize the gaze cues of others when the cues provide useful information.
Mirror-Integrated Transparent Antenna for RFID Application (2011)

An optically transparent antenna array is presented for radio frequency identification (RFID) systems, operating in the ultrahigh frequency (UHF) band. The antenna is intended for nonintrusive integration into the mirror surface of fitting rooms in apparel stores, keeping with the typical small depth of the mirror structure and low cost. The antenna is used to read RFID tags attached to clothes being tried on, so that the associated system can automatically provide the client with interactive information regarding that specific piece of clothing. The antenna ensures self-confined reading range in front of the mirror, avoiding undesired detection of RFID tags from adjacent fitting rooms. The final antenna solution shows a good compromise between transparency and performance, with well-confined RFID detection volume.
The Carbocyclic Analogue of 5-(1-Propenyl)-2′-Deoxyuridine; Synthesis and Anti-Herpes Activity (1986)

Abstract The title compound was synthesised and tested against HSV-1 in cell culture. Like related compounds, it was less active than the parent nucleoside.
Self-Association of CIITA and Its Transactivation Potential (2001)

The major histocompatibility complex (MHC) class II transactivator (CIITA) regulates the expression of genes involved in the immune response, including MHC class II genes and the interleukin-4 gene. Interactions between CIITA and sequence-specific, DNA-binding proteins are required for CIITA to function as an activator of MHC class II genes. CIITA also interacts with the coactivators CBP (also called p300), and this interaction leads to synergistic activation of MHC class II promoters. Here, we report that CIITA forms complexes with itself and that a central region, including the GTP-binding domain is sufficient for self-association. Additionally, this central region interacts with the C-terminal leucine-rich repeat as well as the N-terminal acidic domain. LXXLL motifs residing in the GTP-binding domain are essential for self-association. Finally, distinct differences exist among various CIITA mutant proteins with regard to activation function, subcellular localization, and association with wild-type protein and dominant-negative potential.
High-Performance Solar-Blind Photodetectors Based on Al&lt;tex&gt;$_rm x$&lt;/tex&gt;Ga&lt;tex&gt;$_1-rm x$&lt;/tex&gt;N Heterostructures (2004)

Design, fabrication, and characterization of high-performance Al/sub x/Ga/sub 1-x/N-based photodetectors for solar-blind applications are reported. Al/sub x/Ga/sub 1-x/N heterostructures were designed for Schottky, p-i-n, and metal-semiconductor-metal (MSM) photodiodes. The solar-blind photodiode samples were fabricated using a microwave compatible fabrication process. The resulting devices exhibited extremely low dark currents. Below 3fA, leakage currents at 6-V reverse bias were measured on p-i-n samples. The excellent current-voltage (I--V) characteristics led to a detectivity performance of 4.9/spl times/10/sup 14/ cmHz/sup 1/2/W/sup -1/. The MSM devices exhibited photoconductive gain, while Schottky and p-i-n samples displayed 0.09 and 0.11 A/W peak responsivity values at 267 and 261 nm, respectively. A visible rejection of 2/spl times/10/sup 4/ was achieved with Schottky samples. High-speed measurements at 267 nm resulted in fast pulse responses with greater than gigahertz bandwidths. The fastest devices were MSM photodiodes with a maximum 3-dB bandwidth of 5.4 GHz.
Mitochondrial Targeting of Vitamin E Succinate Enhances Its Pro-apoptotic and Anti-cancer Activity via Mitochondrial Complex II (2010)

Mitochondrial complex II (CII) has been recently identified as a novel target for anti-cancer drugs. Mitochondrially targeted vitamin E succinate (MitoVES) is modified so that it is preferentially localized to mitochondria, greatly enhancing its pro-apoptotic and anti-cancer activity. Using genetically manipulated cells, MitoVES caused apoptosis and generation of reactive oxygen species (ROS) in CII-proficient malignant cells but not their CII-dysfunctional counterparts. MitoVES inhibited the succinate dehydrogenase (SDH) activity of CII with IC(50) of 80 μM, whereas the electron transfer from CII to CIII was inhibited with IC(50) of 1.5 μM. The agent had no effect either on the enzymatic activity of CI or on electron transfer from CI to CIII. Over 24 h, MitoVES caused stabilization of the oxygen-dependent destruction domain of HIF1α fused to GFP, indicating promotion of the state of pseudohypoxia. Molecular modeling predicted the succinyl group anchored into the proximal CII ubiquinone (UbQ)-binding site and successively reduced interaction energies for serially shorter phytyl chain homologs of MitoVES correlated with their lower effects on apoptosis induction, ROS generation, and SDH activity. Mutation of the UbQ-binding Ser(68) within the proximal site of the CII SDHC subunit (S68A or S68L) suppressed both ROS generation and apoptosis induction by MitoVES. In vivo studies indicated that MitoVES also acts by causing pseudohypoxia in the context of tumor suppression. We propose that mitochondrial targeting of VES with an 11-carbon chain localizes the agent into an ideal position across the interface of the mitochondrial inner membrane and matrix, optimizing its biological effects as an anti-cancer drug.
CREAM: Criteria‐Related Employability Assessment Method: (1994)

Presents an improved replicable systematic method for the selection or promotion of employees through the developmental stages of a case study. The method provides systematic techniques for ensuring fairness and equality of opportunity for all candidates as related to particular job functions. The Criteria‐Related Employability Assessment Method (CREAM) has gone through continuous improvement over the past 20 years. The case study is of a new firefighter recruit selection process developed for the Phoenix Fire Department. Criteria were drawn from a group of the organization′s currently successful employees. Follow‐up research of those candidates selected for the first two firefighter recruit training classes showed that there was a significantly high correlation between the selected candidates and the criteria group of successful Phoenix firefighters. The playing field being levelled resulted in a significant increase in the number of minority group members and females that were selected to be on the hiring list. The method can be replicated and is applicable to other organizations in both the public and private sectors, such as fire departments, police departments, large corporations and government employee training programmes. Concludes that CREAM does remove or at least neutralize a great deal of the uses of personali ower, political manoeuvring, quotas and other special internal selection methods while meeting most if not all the external regulatory requirements, and assists in ensuring that the people selected know they were selected for who they are and not for just what they are.
Exciton Formation and Annihilation during 1D Impact Excitation of Carbon Nanotubes (2006)

Near-infrared electroluminescence was recorded from unipolar single-wall carbon nanotube field-effect transistors at high drain-source voltages. High resolution spectra reveal resonant light emission originating from the radiative relaxation of excitons rather than heat dissipation. The electroluminescence is induced by only one carrier type and ascribed to 1D impact excitation. An emission quenching is also observed at high field and attributed to an exciton-exciton annihilation process and free carrier generation. The excitons' binding energy in the order of 270 meV for 1.4 nm SWNTs is inferred from the spectral features.
COMPARATIVE STUDIES ON IMMUNOLOGICALLY AND NON‐IMMUNOLOGICALLY PRODUCED SLOW‐REACTING SUBSTANCES FROM MAN, GUINEA‐PIG AND RAT (1979)

Slow‐reacting substance of anaphylaxis (SRS‐A) was produced by antigen challenge of passively sensitized human lung and actively sensitized guinea‐pig lung. A slow‐reacting substance (SRS) was prepared from the peritoneal fluid of rats treated with calcium ionophore A23187. These substances were extensively purified by charcoal adsorption, Sephadex G‐15 gel filtration, ether extraction and reverse phase high pressure liquid chromatography. The three substances are pharmacologically, chemically and chromatographically indistinguishable. Our data suggest that the same SRS entities are released from a variety of tissues and that these acidic lipids may have a wider physiological significance than just anaphylaxis.
[Relations between the physico-chemical properties, the chemical reactivity and the local anesthetic activity. 32. (Part 1): Binding capacity of a structural protein (wool) to local anesthetics]. (1975)

1. The general part deals with the molecular structure of nerve membranes and different local-anesthetic substances as well as the various possibilities of local-anesthetic binding to the nerve membrane. Albumin is usually chosen as a model protein in such investigations, a short extract of which is given. 2. The special part includes the chemical composition and properties of wool macroprotein, the model system used in the present paper. We determined its protein-binding values with cinchocain and tetracain homologues and various known commercial products of local anesthetics (oxybuprocain, parethoxyprocain and tetracain). The binding constants of these substances on wool protein are shown. 3. A statistically confirmed relationship between the alkyl chain length and the strength of protein binding is given. The free energy per CH2-group ranges between 400 and 500 cal/mol and its larger in cases of low pH values. 4. From the present data, a relationship between the binding constant and the partition constant of each substance of the homologous series studied could easily be observed, which further makes it possible to estimate the characteristic protein-binding constant Kp and also the change in pi-values with the change in free reaction energy of the substances. 5. The large differences in the binding values of the different binding mechanisms, which most probably are dependent on the variable binding affinities of the functional groups as well as on steric factors. But as in the homologous series, only substituents like alkyl amino and alkoxy could be changed, the possibility of some other binding process depending on the alkyl chain length of these groups could not be ruled out. Since the alky groups are non-polar, hydrophobic binding plays a role.
Image Encryption Based on Composite Chaotic System (2006)

This paper proposes an image encryption system based on composite chaotic system. A three dimensional Chen’s system which has a complex dynamical behavior and a one dimensional logistic chaotic mapping are employed in the encryption system. The output sequences of these two chaotic systems are composed by using a special method, and a fast image encryption is realized by means of the bit-wise xor operations. The results of simulation experiments and security analyses indicate that this encryption system not only has a large key space but also has a very sensitivity with respect to the secret key and the original image. The encryption system proposed in this paper possesses perfect diffusion and confusion properties and it can resist the know-plaintext attacks and chosen-plaintext attacks.
THREE-DIMENSIONAL FLOW AND BED TOPOGRAPHY IN SAND-SILT MEANDERING RIVERS (1986)

Mathematical models for defining three-dimensional turbulent flow and bed topography in meandering sand-silt rivers are presented, and interaction between them is analyzed. It is revealed theoretically that the secondary flow shows reduction in its magnitude from that of uniformly-curved open channels and shows phase-lag against the channel plan-form. A model for defining bed topography is derived by considering sediment balance for both bed load and suspended load, the transport rates and directions of which are obtained from the flow field thus determined. Laboratory tests have supported the present models. The study presented herein has made it possible to predict the large-scale bed topography of meandering sand-silt rivers such as the magnitude and the location of local scour and point-bar deposit.
The Role of Intracellular 35-Cyclic Adenosine Monophosphate (cAMP) in Atherosclerosis (2010)

Intracellular cAMP is an ubiquitous intracellular second messenger that regulates important cellular functions. Intracellular cAMP levels are regulated by the enzymes adenylyl cyclase and phosphodiesterases. The role of cAMP in atherosclerosis is not widely accepted and incompletely characterized. Several reports support a role of cAMP in atherogenesis by modulating the function of vascular endothelium, the production of reactive oxygen species, the recruitment of circulating monocytes to the artery wall and their differentiation into macrophages- foam cells, by controlling the expression of pro- and anti-inflammatory interleukins, and regulating serum levels of triglycerides and cholesterol. Previous reports suggested an important role of cAMP in the modulation of atherosclerotic plaque progression by removal of excess free cholesterol from macrophages by inducing the ABCA1 secretory pathway and reducing circulating levels of cholesterol. Studies suggested a crucial role of cAMP on the development of acute coronary syndromes [(ACS); unstable angina, and acute myocardial infarction] and stroke, by modulating platelet aggregation and thrombus formation and the expression of metalloproteinases. This review focuses on the identified mechanisms and roles of cAMP in the prevention of atherosclerosis, atherogenesis, and progression of atherosclerosis and the development of ACS. Finally, it provides evidence that showed the beneficial effects that may derive from the inhibition of phosphodiesterase III and activation of adenylyl cyclase and subsequent elevation of cAMP levels. Thus, cAMP may be a possible target for the prevention and treatment of atherosclerosis.
Traffic control via moving bottleneck of coordinated vehicles (2018)

We investigate the possibility of properly controlling a given vehicle to improve overall traffic flow. The system is described by a micro-macro model taking into account the interactions of the vehicle with the surrounding traffic. We state an optimal control problem using the maximal speed of the coordinated vehicle as control variable. More precisely, we use the MPC (Model Predictive Control) approach to get a fuel consumption reduction when the traffic is congested due to the presence of a fixed downstream bottleneck on the highway. In addition we show that the control application also improves the average travel time and queue length. The concept illustrated in this paper suggests innovative future traffic control approaches. Indeed the perspective of exploiting controlled vehicles to regulate the traffic flow is particularly attractive given the expected increasing penetration rate of autonomous vehicles in traffic networks in future years.
VÍCTIMAS Y REVOLUCIONARIOS. ACERCA DE CÓMO LOS INTEGRANTES DE LA AGRUPACIÓN HIJOS LA PLATA RECUERDAN A SUS PADRES (2007)

Este trabajo es una aproximación etnográfica preliminar a la agrupación HIJOS La Plata. Se trata de comprender cuál es laparticularidad de esta agrupación dentro del movimiento de Derechos Humanos a partir de un análisis del modo en que construyenla memoria sobre sus padres. En este marco se destaca la ambivalencia que supone para los integrantes de esta agrupación laidea de que sus padres y ellos mismos han sido víctimas del terrorismo de Estado. De allí que, el pensar a sus padres comorevolucionarios y no sólo como víctimas inocentes los coloca en un escenario lleno de tensiones como es el de las disputas porimponer distintas versiones acerca de lo sucedido durante el terror estatal y el período previo.
Synthesis and Optoelectronic Properties of Starlike Polyfluorenes with a Silsesquioxane Core (2004)

A novel starlike polyfluorene derivative, PFO-SQ, was synthesized by the Ni(0)-catalyzed reaction of octa(2-(4-bromophenyl)ethyl)octasilsesquioxane (OBPE-SQ) and polydioctylfluoroene (PFO). The incorporation of the silsesquioxane core into polyfluorene could significantly reduce the aggregation as well as enhance the thermal stability. The DSC study showed an elimination of the glass transition and crystallization as well as a significant reduction of the melting enthalpy in PFO-SQ. The UV−vis absorption spectra in a different solvent combination or solid-state film showed an intensity reduction of the aggregation peak for PFO-SQ in comparison with that of PFO. The stability of the photoluminescence spectra of PFO-SQ could be up to 150 °C, while that of PFO showed a significant green emission at 530 nm. A single-layer LED device using PFO-SQ showed a turn on voltage of 6.0 V, a brightness of 5430 cd/m2 (at a drive voltage of 8.8 V), and a current density of 0.844 A/cm2. The maximum luminescence intensity and quantum efficiency of PFO-SQ were almost twice as good as those of the PFO electroluminescent device. Hence, the incorporation of the inorganic silsesquioxane core into polyfluorenes could provide a new methodology for preparing organic light-emitting diodes with improved thermal and optoelectronic characteristics.