gebhart/patrepeval huggingface dataset:
Pharmacokinetics of imipenem-cilastatin in patients with renal insufficiency undergoing continuous ambulatory peritoneal dialysis (1988)

In six patients with end-stage renal disease, a single bolus of imipenem-cilastatin (500 mg each) was given either intravenously or intraperitoneally in a randomized crossover protocol such that each patient received the drug by both routes at a 2- to 3-week interval. Drug levels in plasma and the peritoneal dialysis fluid were analyzed at frequent intervals, and various pharmacokinetic variables were calculated for a one-compartment open model. Data obtained in the present study suggest that while no significant difference in peak plasma levels or volume of distribution were noted, the following variables were significantly different for imipenem as compared with cilastatin: elimination half-life, total plasma clearance, area under the concentration-time curve, and percent drug excretion in the peritoneal dialysis fluid. The elimination half-life of imipenem (3.28 h) or cilastatin (8.84 h) in our patients was in the same range as observed in patients with minimal renal function undergoing hemodialysis. The dose of imipenem-cilastatin should be reduced appropriately in patients with end-stage renal disease undergoing peritoneal dialysis.
iDEAL: Incentivized dynamic cellular offloading via auctions (2013)

The explosive growth of cellular traffic and its highly dynamic nature often make it increasingly expensive for a cellular service provider to provision enough cellular resources to support the peak traffic demands. In this paper, we propose iDEAL, a novel auction-based incentive framework that allows a cellular service provider to leverage resources from third-party resource owners on demand by buying capacity whenever needed through reverse auctions. iDEAL has several distinctive features: (i) iDEAL explicitly accounts for the diverse spatial coverage of different resources and can effectively foster competition among third-party resource owners in different regions, resulting in significant savings to the cellular service provider. (ii) iDEAL provides revenue incentives for third-party resource owners to participate in the reverse auction and be truthful in the bidding process. (iii) iDEAL is provably efficient. (iv) iDEAL effectively guards against collusion. (v) iDEAL effectively copes with the dynamic nature of traffic demands. In addition, iDEAL has useful extensions that address important practical issues. Extensive evaluation based on real traces from a large US cellular service provider clearly demonstrates the effectiveness of our approach. We further demonstrate the feasibility of iDEAL using a prototype implementation.
Serum and Plasma Fibronectin Binds to Complement Reacted Immune Complexes Primarily via C1q (1986)

The binding of fibronectin to human Clq, C3b, and complement-reacted immune complexes (IC) was investigated by enzyme-linked immunosorbent assays. Microplates were coated with BSA followed by incubation with rabbit-anti-BSA IgG or F(ab')2 fragments of rabbit anti-BSA. Incubation of the solid phase with serum at 37 degrees C caused attachment of Clq and C3b. Addition of EDTA to the serum inhibited the binding of C3b, but not Clq, whereas substitution of the anti-BSA IgG on the solid phase with the F(ab')2 fragments abrogated the Clq, but not the C3b binding. Fibronectin binding was observed after incubation of the solid-phase IC with serum or plasma at conditions where Clq was also bound, whereas only minor amounts of fibronectin bound to the solid phase IC via C3b. Purified fibronectin showed a dose-dependent binding to solid-phase IC pretreated with Clq or fibronectin-depleted serum, confirming that the binding of fibronectin to IC largely occurred via Clq. Significantly smaller amounts of fibronectin were bound to solid-phase IC incubated with plasma instead of serum, despite the higher fibronectin concentration in plasma. This difference was found not to be due to a fibrinogen-fibronectin interaction in plasma. Binding of fibronectin to preformed fluid phase IC incubated with serum was demonstrated by SDS-PAGE analysis of PEG-precipitated IC.
The Expression of Mitochondrial DNA Transcription Factors during Early Cardiomyocyte <i>In Vitro</i> Differentiation from Human Embryonic Stem Cells (2005)

Mitochondrial biogenesis and activation of both oxidative phosphorylation, as well as transcription and replication of the mitochondrial genome, are key regulatory events in cell differentiation. Mitochondrial DNA transcription and replication are highly dependent on the interaction with nuclear-encoded transcription factors translocated from the nucleus. Using a human embryonic stem cell line, HSF 6, we analyzed the proliferation of mitochondria and the expression of mtDNA-specific transcription factors in undifferentiated, migratory embryonic stem cells and spontaneously derived cardiomyocytes. Mitochondrial proliferation and mtDNA transcription are initiated in human embryonic stem cells as they undergo spontaneous differentiation in culture into beating cardiomyocytes. Undifferentiated, pluripotent human embryonic stem cells have few mitochondria, and, as they differentiate, they polarize to one extremity of the cell and then bipolarize the differentiating cell. The differentiated cell then adopts the cytoplasmic configuration of a somatic cell as evidenced in differentiating cardiomyocytes. Transcription and replication of the extranuclear mitochondrial genome is dependent on nuclear encoded factors exported to the mitochondrion. However, the differentiating cardiomyocytes have reduced or absent levels of these transcription and replication factors, namely mitochondrial transcription factors A, B1, B2, and nuclear respiratory factor 1 and polymerase gamma. Therefore, final embryonic stem cell commitment may be influenced by mitochondrial proliferation and mtDNA transcription. However, it is likely that differentiating cardiomyocytes are in mitochondrial arrest, awaiting commitment to a final cell fate.
Endoscopic therapy for GERD--baking, sewing, or stuffing: an evidence-based perspective. (2003)

The concept of using endoscopic therapy for the treatment of symptomatic gastroesophageal reflux disease (GERD) is a relatively recent development. Currently, three basic techniques are approved for use in the United States. To date, clinical trials have examined either a thermal approach, endoscopic suturing, or injection intervention in the area of the lower esophageal sphincter. However, the trials for each type of endoscopically directed therapy have varied in methodologic design and data analysis. It is important to recognize these differences when attempting to compare the efficacy and outcomes for each endoscopic therapy. Additionally, the risk/benefit profile must be carefully evaluated for each of these interventions before considering it a viable treatment strategy.
cDNA Cloning and Interferon γ Down-Regulation of Proteasomal Aubunits X and Y (1994)

Proteasomes are the proteolytic complex responsible for major histocompatibility complex (MHC) class I-restricted antigen presentation. Interferon gamma treatment increases expression MHC-encoded LMP2 and LMP7 subunits of the proteasome and decreases expression of two proteasome subunits, named X and Y, which alters the proteolytic specificity of proteasomes. Molecular cloning of complementary DNAs encoding X and Y showed that their proteins are proteasomal subunits with high amino acid similarity to LMP7 and LMP2, respectively. Thus, interferon gamma may induce subunit replacements of X and Y by LMP7 and LMP2, respectively, producing proteasomes perhaps more appropriate for the immunological processing of endogenous antigens.
Multiple-View Geometry Under the {$L_\infty$}-Norm (2008)

This paper presents a new framework for solving geometric structure and motion problems based on Linfinity-norm. Instead of using the common sum-of-squares cost-function, that is, the L2-norm, the model-fitting errors are measured using the L-norm. Unlike traditional methods based on L2, our framework allows for efficient computation of global estimates. We show that a variety of structure and motion problems, for example, triangulation, camera resectioning and homography estimation can be recast as quasi-convex optimization problems within this framework. These problems can be efficiently solved using Second-Order Cone Programming (SOCP) which is a standard technique in convex optimization. The methods have been implemented in Matlab and the resulting toolbox has been made publicly available. The algorithms have been validated on real data in different settings on problems with small and large dimensions and with excellent performance.
An adaptive system for the personalized access to news (2001)

this paper we present SeAN (Server for Adaptive News), an adaptive system for the personalized access to news servers on the WWW. The aims of the system are (i) to select the sections (topics) and news in the server that are most relevant for each user, (ii) to customize the detail level of each news item to the user&apos;s characteristics and (iii) to select the advertisements that are most appropriate for each page and user. In the paper we discuss the functionalities of the system and we present the choices we made in its design. In particular, we focus on the techniques we adopted for structuring the news archive, for creating and maintaining the user model and for generating the personalized hypertext for browsing the news server. Keywords: User modeling, adaptive systems, news servers on the World Wide Web 1. Introduction The possibility of providing customized services [45], i.e., services tailored to the needs and preferences of the individual user (customer) has
Reducing inconsistency in integrating data from different sources (2002)

One of the main problems in integrating databases into a common repository is the possible inconsistency of the values stored in them, i.e., the very same term may have different values, due to misspelling, a permuted word order, spelling variants and so on. The authors present an automatic method for reducing inconsistency found in existing databases, and thus, improving data quality. All the values that refer to a same term are clustered by measuring their degree of similarity. The clustered values can be assigned to a common value that, in principle, could be substituted for the original values. We evaluate four different similarity measures for clustering with and without expansion of abbreviations. The method we propose may work well in practice but it is time-consuming. In order to reduce this problem, we remove stop words for speeding up the clustering.
Speaker Identification using SVM during Oriya Speech Recognition (2015)

Abstract—In this research paper, we have developed a system that identifies users by their voices and helped them to retrieve the information using their voice queries. The system takes into account speaker identification as well as speech recognition i.e. two pattern recognition techniques in speech domain. The conglomeration of speaker identification task and speech recognition task provides multitude of facilities in comparison to isolated approach. The speaker identification task is achieved by using SVM where as speech recognition is based on HMM. We have used two different types of corpora for training the system. Gamma tone cepstral coefficients and mel frequency cepstral coefficients are extracted for speaker identification and speech recognition respectively. The accuracy of the system is measured from two perspective i.e. accuracy of speaker identity and accuracy of speech recognition task. The accuracy of the speaker identification is enhanced by adopting the speech recognition at the initial stage of speaker identification. Index Terms—Speaker identification, speech recognition, mel-frequency cepstral coefficients, gammatone frequency cepstral coefficients, support vector machine. I.
On Mesoscopic Forces and Quantized Conductance in Model Metallic Nanowires (1997)

Energetics and conductance in jellium-modeled nanowires are investigated using the local-density-functional-based shell correction method. In analogy with studies of other finite-size fermion systems, e.g., simple metal clusters or 3He clusters, we find that the energetics of the wire as a function of its radius (transverse reduced dimension) leads to formation of self-selecting magic wire configurations (MWCs, i.e., discrete sequence of wire radii with enhanced stability), originating from quantization of the electronic spectrum, namely formation of subbands that are the analogs of electronic shells in clusters. These variations in the energy result in oscillations in the force required to affect a transition from one MWC of the nanowire to another and are correlated directly with stepwise variations of the quantized conductance of the nanowire in units of 2e2/h.
Preparation of an Antigen-Sensitive Hydrogel Using Antigen−Antibody Bindings (1999)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTPreparation of an Antigen-Sensitive Hydrogel Using Antigen−Antibody BindingsTakashi Miyata, Noriko Asami, and Tadashi UragamiView Author Information Chemical Branch, Faculty of Engineering and High Technology Research Center, Kansai University, Suita, Osaka, 564-8680 Japan Cite this: Macromolecules 1999, 32, 6, 2082–2084Publication Date (Web):February 24, 1999Publication History Received23 October 1998Revised20 January 1999Published online24 February 1999Published inissue 1 March 1999https://pubs.acs.org/doi/10.1021/ma981659ghttps://doi.org/10.1021/ma981659grapid-communicationACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views1907Altmetric-Citations144LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Absorption,Antigens,Hydrogels,Nucleic acid structure,Phosphates Get e-Alerts
Design of narrowband, high-resolution multisines (1996)

A method is presented to minimize the crest factor of narrowband high-resolution multisines. An adequate use of the envelope of the signal allows a significant reduction of both the required memory space and the calculation time as compared with a direct approach. A lower bound for the attainable crest factor is derived, and it is demonstrated on some experiments that the proposed algorithm comes very close to this bound.
Induction Heat Treating Systems (2014)

Abstract Induction heating has many different applications, such as melting, heating stock for forging, and heat treating. This article begins with a discussion on the types of power supplies, namely, solid-state power supplies and oscillator tubes. It provides information on system elements, including cooling systems, power supplies, heat stations, work handling fixtures, induction or work coils, and quench systems. The article discusses the influence of system elements on induction heat treating system design. It also deals with the general theory, types, and applications of induction coils.
Superconducting Critical Temperature of Overdoped LnBa<sub>2</sub>Cu<sub>3</sub>O<sub>y+Δy</sub> (Ln=La, Nd, Sm, Eu, Gd, Dy, Ho, Er, Tm and Yb) (1999)

A series of overdoped LnBa 2 Cu 3 O y +Δ y (Ln=La∼Yb) was synthesized at high oxygen pressure for investigating the relationship between the superconducting critical temperature T c , overdoping oxygen content Δ y , and Ln. T c of 1-2-3 compound LnBa 2 Cu 3 O y +Δ y remains almost unchanged through various levels of overdoping for small ionic radii of Ln. As the ionic radus of Ln increases, T c decreases with the level of overdoping. The decrease changes systematically from EuBa 2 Cu 3 O y +Δ y to LaBa 2 Cu 3 O y +Δ y ; the decrease for LaBa 2 Cu 3 O y +Δ y is the steepest. T c is also reduced probably by the mixing of Ln and Ba, as observed in NdBa 2 Cu 3 O y +Δ y and LaBa 2 Cu 3 O y +Δ y .
Binding of transition metals by apolipoprotein A-I-containing plasma lipoproteins: inhibition of oxidation of low density lipoproteins. (1992)

We have found transition metals tightly bound to apolipoprotein A-I-containing lipoproteins [Lp(A-I)] isolated by selected affinity immunosorption from human serum. Prominent among the metal ions detected were iron and copper. By immunoblotting the proteins of Lp(A-I), we detected both transferrin and ceruloplasmin. The transferrin-containing Lp(A-I) particles, isolated by selected affinity immunosorption against transferrin, were larger (mean diameter of 14.2 nm) and had a higher protein content than most high density lipoproteins (HDL). Ultracentrifugally isolated HDL were found to contain much less transferrin, whereas transferrin was found associated with apolipoprotein A-I from the greater than 1.21-g/ml ultracentrifugal fraction. This suggests that the complex is not recovered in the classic HDL density interval because of its very high density. HDL inhibit copper-catalyzed oxidation of low density lipoproteins (LDL) in vitro. We have found that immunoisolated Lp(A-I) are an order of magnitude more effective in inhibiting the oxidation of LDL than ultracentrifugally isolated HDL, on the basis of protein mass. When the Lp(A-I) particles containing transferrin and ceruloplasmin were removed from the bulk of Lp(A-I), inhibition of the in vitro oxidation of LDL was significantly decreased.
Supercritical Processing as a Route to High Internal Surface Areas and Permanent Microporosity in Metal−Organic Framework Materials (2008)

Careful processing of four representative metal-organic framework (MOF) materials with liquid and supercritical carbon dioxide (ScD) leads to substantial, or in some cases spectacular (up to 1200%), increases in gas-accessible surface area. Maximization of surface area is key to the optimization of MOFs for many potential applications. Preliminary evidence points to inhibition of mesopore collapse, and therefore micropore accessibility, as the basis for the extraordinarily efficacious outcome of ScD-based activation.
Implementation of model predictive control using real-time multiprocessing computing (2003)

This work addresses the issue of finding the programming procedure that results to the fastest implementation of the core calculations of the model predictive control (MPC) algorithms that are amenable to parallel processing on a real-time multiprocessing system. Three concurrent programming procedures were considered for the MPC implementation, each one consisting of a number of tasks configured to a linear array, mesh and tree parallel architectures. Both theoretical analysis and measurements, taken from running these procedures on a four-processor computer platform, indicate that the procedure of the linear array architecture presents the best speed-up ratio.
Cross talk of tyrosine kinases with the DNA damage signaling pathways (2015)

Tyrosine kinases respond to extracellular and intracellular cues by activating specific cellular signaling cascades to regulate cell cycle, growth, proliferation, differentiation and survival. Likewise, DNA damage response proteins (DDR) activated by DNA lesions or chromatin alterations recruit the DNA repair and cell cycle checkpoint machinery to restore genome integrity and cellular homeostasis. Several new examples have been uncovered in recent studies which reveal novel epigenetic and non-epigenetic mechanisms by which tyrosine kinases interact with DDR proteins to dictate cell fate, i.e. survival or apoptosis, following DNA damage. These studies reveal the ability of tyrosine kinases to directly regulate the activity of DNA repair and cell cycle check point proteins by tyrosine phosphorylation. In addition, tyrosine kinases epigenetically regulate DNA damage signaling pathways by modifying the core histones as well as chromatin modifiers at critical tyrosine residues. Thus, deregulated tyrosine kinase driven epigenomic alterations have profound implications in cancer, aging and genetic disorders. Consequently, targeting oncogenic tyrosine kinase induced epigenetic alterations has gained significant traction in overcoming cancer cell resistance to various therapies. This review discusses mechanisms by which tyrosine kinases interact with DDR pathways to regulate processes critical for maintaining genome integrity as well as clinical strategies for targeted cancer therapies.
Cell division is antagonized by the activity of peptidoglycan endopeptidases that promote cell elongation (2020)

A peptidoglycan (PG) cell wall composed of glycans crosslinked by short peptides surrounds most bacteria and protects them against osmotic rupture. In Escherichia coli, cell elongation requires crosslink cleavage by PG endopeptidases to make space for the incorporation of new PG material throughout the cell cylinder. Cell division, on the contrary, requires the localized synthesis and remodeling of new PG at midcell by the divisome. Little is known about the factors that modulate transitions between these two modes of PG biogenesis. In a transposon-insertion sequencing screen to identify mutants synthetically lethal with a defect in the division protein FtsP, we discovered that mutants impaired for cell division are sensitive to elevated activity of the endopeptidases. Increased endopeptidase activity in these cells was shown to interfere with the assembly of mature divisomes, and conversely, inactivation of MepS was found to suppress the lethality of mutations in essential division genes. Overall, our results are consistent with a model in which the cell elongation and division systems are in competition with one another and that control of PG endopeptidase activity represents an important point of regulation influencing the transition from elongation to the division mode of PG biogenesis.
New stable IIR modeling of long FIR filters with low complexity (2008)

This paper presents a new efficient method for stable pole-zero modeling of long finite impulse response (FIR) filters. The proposed method is based on the formulation of a generalized system identification problem using the minimum mean-square error (MMSE) criterion. A computationally efficient MMSE solution is then derived by exploiting the structured matrices. The proposed method is general and applicable to cases with unequal numbers of poles and zeros. Compared with the generalized ARMA-Levinson algorithm, the proposed method has lower computational complexity without loss of accuracy. Numerical results are provided to demonstrate the effectiveness of the proposed method.
A floating-gate analog memory with bidirectional sigmoid updates in a standard digital process (2013)

A floating-gate current-output analog memory is implemented in a 0.13-μm digital CMOS process. The proposed memory cell achieves random-accessible and bidirectional updates with a sigmoid update rule. A novel writing scheme is proposed to obtain tunneling selectivity without on-chip highvoltage switches or charge pumps, and reduces interconnections and pin count. Parameters of empirical models for floating gate charge modification are extracted from measurements. Measurement and simulation results show that the proposed memory consumes 45 nW of power, has a 7-bit programming resolution, 53.8 dB dynamic range and 86.5 dB writing isolation.