gebhart/patrepeval huggingface dataset:
Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant p53 (2012)

The destabilizing p53 cancer mutation Y220C creates a druggable surface crevice. We developed a strategy exploiting halogen bonding for lead discovery to stabilize the mutant with small molecules. We designed halogen-enriched fragment libraries (HEFLibs) as starting points to complement classical approaches. From screening of HEFLibs and subsequent structure-guided design, we developed substituted 2-(aminomethyl)-4-ethynyl-6-iodophenols as p53-Y220C stabilizers. Crystal structures of their complexes highlight two key features: (i) a central scaffold with a robust binding mode anchored by halogen bonding of an iodine with a main-chain carbonyl and (ii) an acetylene linker, enabling the targeting of an additional subsite in the crevice. The best binders showed induction of apoptosis in a human cancer cell line with homozygous Y220C mutation. Our structural and biophysical data suggest a more widespread applicability of HEFLibs in drug discovery.
Clostridium perfringens type C in bloody and watery diarrhea in Bangladesh. (1990)

A two-week age-matched case-control survey to detect Clostridium perfringens type C-associated illness was conducted among diarrheal patients hospitalized following the consumption of high protein meals on the occasion of an annual religious festival. From the stool of 33 patients screened, C. perfringens type C was isolated from one patient with bloody diarrhea and from two patients with watery diarrhea. In Bangladesh, C. perfringens type C has been isolated in both bloody and watery diarrhoeal illness and is not necessarily associated with necrotizing enteritis (pigbel).
The Raid-6 Liber8Tion Code (2009)

Large centralized and networked storage systems have grown to the point where the single fault tolerance provided by RAID-5 is no longer enough. RAID-6 storage systems protect k disks of data with two parity disks so that the system of k + 2 disks may tolerate the failure of any two disks. Coding techniques for RAID-6 systems are varied, but an important class of techniques are those with minimum density, featuring an optimal combination of encoding, decoding and modification complexity. The word size of a code has an impact on both how the code is laid out on each disk's sectors and how large k can be. Word sizes which are powers of two are especially important, since they fit precisely into file system blocks. Minimum density codes exist for many word sizes with the notable exception of eight. This paper fills that gap by describing a new code called The RAID-6 Liber8tion Code for this important word size. The description includes performance properties as well as details of the discovery process.
Analyzing the overload behavior of a simple web server (2000)

Linux introduces POSIX Real Time signals to report I/O activity on multiple connections with more scalability than traditional models. In this paper we explore ways of improving the scalability and performance of POSIX RT signals even more by measuring system call latency and by creating bulk system calls that can deliver multiple signals at once. 1. Introduction Experts on network server architecture have argued that servers making use of I/O completion events are more scalable than today&apos;s servers [2, 3, 5]. In Linux, POSIX Real-Time (RT) signals can deliver I/O completion events. Unlike traditional UNIX signals, RT signals carry a data payload, such as a specific file descriptor that just completed. Signals with a payload can enable network server applications to respond immediately to network requests, as if they were event-driven. An added benefit of RT signals is that they can be queued in the kernel and delivered to an application one at a time, in order, leaving an applic...
Encyclopedia of inland waters (2009)

Inland aquatic habitats occur world-wide at all scales from marshes, swamps and temporary puddles, to ponds, lakes and inland seas; from streams and creeks to rolling rivers. Vital for biological diversity, ecosystem function and as resources for human life, commerce and leisure, inland waters are a vital component of life on Earth. The Encyclopedia of Inland Waters describes and explains all the basic features of the subject, from water chemistry and physics, to the biology of aquatic creatures and the complex function and balance of aquatic ecosystems of varying size and complexity. Used and abused as an essential resource, it is vital that we understand and manage them as much as we appreciate and enjoy them. This extraordinary reference brings together the very best research to provide the basic and advanced information necessary for scientists to understand these ecosystems - and for water resource managers and consultants to manage and protect them for future generations. Encyclopedic reference to Limnology is a key core subject in ecology taught as a specialist course in universities. Over 240 topic related articles cover the field. Gene Likens is a renowned limnologist and conservationist, Emeritus Director of the Institute of Ecosystems Research, elected member of the American Philosophical Society and recipient of the 2001 National Medal of Science. Subject Section Editors and authors include the very best research workers in the field.
Optimization of H-Shape Micro strip Patch antenna Using PSO and Curve Fitting (2017)

In the Result show that PSO optimized antenna resonance exactly at 2.4Ghz and also improvement in bandwidth from 16.10% to 18.22%.
Tape That Increases Medial Longitudinal Arch Height Also Reduces Leg Muscle Activity (2008)

: APT reduces activity of the TA and TP muscles during walking while increasing AH, which provides preliminary evidence of its role in reducing the load of these key extrinsic muscles of the ankle and the foot. Follow-up study is required to evaluate these findings.
Spherical Polyelectrolyte Brushes on Colloidal Poly(butadiene) Particles (2012)

Abstract A novel method to prepare spherical polyelectrolyte brushes (SPB) on the surface of colloidal poly(butadiene) (PB) core without having to use initiators with C=C double bond to attach covalently on the core surface was reported. Making use of the abundant double bonds in PB, spherical poly(acrylic acid) (PAA) bushes were grown from PB core surface by direct thermo-initiated emulsion polymerization using KPS as initiator. The thickness of SPB increased significantly upon increasing pH and decreasing the ionic strength. The grafting density of SPB with PB core was estimated from the relationship between the brush thickness and ionic strength based on the modified Daoud-Cotton model. The grafting density of SPB prepared by thermo-initiated emulsion polymerization (0.122 nm -2 ) is higher that that of SPB by photo-emulsion polymerization (0.105 nm -2 ). Using SPB with PB core as nanoreactors, nickel and silver nanoparticles were prepared by reduction of Ni 2+ and Ag + absorbed inside SPB as counterions. Relatively high catalytic activities for the reduction of p -nitrophenol by NaBH 4 were observed for SPB immobilized Ni or Ag nanoparticles.
Effect of Alcohol Structure on the Kinetics of Etherification and Dehydration over Tungstated Zirconia (2018)

Linear and branched ether molecules have attracted recent interest as diesel additives and lubricants that can be produced from biomass-derived alcohols. In this study, tungstated zirconia was identified as a selective and green solid acid catalyst for the direct etherification of primary alcohols in the liquid phase, achieving ether selectivities of >94 % for C<sub>6</sub> -C<sub>12</sub> linear alcohol coupling at 393 K. The length of linear primary alcohols (C<sub>6</sub> -C<sub>12</sub> ) was shown to have a negligible effect on apparent activation energies for etherification and dehydration, demonstrating the possibility to produce both symmetrical and asymmetrical linear ethers. Reactions over a series of C<sub>6</sub> alcohols with varying methyl branch positions indicated that substituted alcohols (2°, 3°) and alcohols with branches on the β-carbon readily undergo dehydration, but alcohols with branches at least three carbons away from the -OH group are highly selective to ether. A novel model compound, 4-hexyl-1dodecanol, was synthesized and tested to further demonstrate this structure-activity relationship. Trends in the effects of alcohol structure on selectivity were consistent with previously proposed mechanisms for etherification and dehydration, and help to define possible pathways to selectively form ethers from biomass-derived alcohols.
Evaluating the Quality of Social Media Data in Big Data Architecture (2015)

The use of freely available online data is rapidly increasing, as companies have detected the possibilities and the value of these data in their businesses. In particular, data from social media are seen as interesting as they can, when properly treated, assist in achieving customer insight into business decision making. However, the unstructured and uncertain nature of this kind of big data presents a new kind of challenge: how to evaluate the quality of data and manage the value of data within a big data architecture? This paper contributes to addressing this challenge by introducing a new architectural solution to evaluate and manage the quality of social media data in each processing phase of the big data pipeline. The proposed solution improves business decision making by providing real-time, validated data for the user. The solution is validated with an industrial case example, in which the customer insight is extracted from social media data in order to determine the customer satisfaction regarding the quality of a product.
Spatial interactions of opposite vasomotor reflexes. (1980)

The simultaneous interactions of pressor and depressor reflexes evoked by stimulation of the central ends of the vagal, tibial and median nerves were studied in urethan and chloralose-urethan anaesthetized cats. The responses obtained to simultaneous activations of opposite reflexes differed from the algebraic sum of the separately evoked ones. The direction and the extent of the differences were determined by the type of the prevailing neural process and by the size of the individual reflex responses. The relations between the responses evoked simultaneously and separately may be characterized by multiple linear regression.
[Androgens: a critical study of the biological diagnosis of the hirsute women. Screening for incomplete blockage of 21-hydroxylase]. (1983)

In 19 patients with unexplained hirsutism without virilisation, a check-up includes delta 4- androstenedione (A), testosterone, DHEA-S. A appears like the best hyperandrogenemia parameter. Nevertheless 5 patients among this group have normal values of all these hormones. A mild congenital adrenal hyperplasia by 21 hydroxylase deficiency is revealed by abnormal response of 17 -OH-progesterone in the cosyntropin test. Our normal value of delta-OHP is, according to Gutai, method, 1.58 +/- 0.83 NG/DL/MN.
The chemotherapy of rodent malaria, XXXVIII. Studies on the activity of three new antimalarials (WR 194,965, WR 228,258 and WR 225,448) against rodent and human malaria parasites (Plasmodium berghei and P. falciparum). (1984)

In addition to their blood schizontocidal action on Plasmodium berghei in vivo, two Mannich bases WR 194,965 and 228,258 are also active against chloroquine-sensitive and chloroquine-resistant lines of P. falciparum in vitro. The response of the lines to each drug differs but shows no correlation in either case with response to chloroquine. The 8-aminoquinoline WR 225,448 is also active against P. falciparum in vitro but at much higher concentrations than the Mannich bases. Application of the 'chloroquine-induced pigment clumping (CIPC) test' and the study of ultrastructural changes induced in P. berghei in drug-treated mice indicate that WR 194,965 has a mode of action somewhat resembling that of quinine. WR 228,258 in vitro shows a chloroquine-like effect, but not in vivo, suggesting that its mode of action in vivo is different from that of chloroquine. WR 225,448 has no action in the CIPC in vitro and affects primarily mitochondria of the parasites in vivo. It probably acts through a metabolite. Both pre-erythrocytic and erythrocytic stages of rodent malaria parasites are affected by WR 225,448.
The NA-MIC Kit: ITK, VTK, Pipelines, Grids and 3D Slicer as An Open Platform for the Medical Image Computing Community (2006)

Medical image computing researchers often face the problem of moving promising new algorithms from the proof of concept stage into a form compatible with clinical use. Algorithm developers lack the time and resources to engineer their code for robustness and compatibility, while end-users are anxious to try new techniques but require well designed and tested user interfaces to make practical use of them. The NA-MIC Kit is a collection of software and methodology specifically designed to address these problems and facilitate the rapid advancement of the field
A Complete Guide to the Futures Markets: Fundamental Analysis, Technical Analysis, Trading, Spreads, and Options (1984)

Partial table of contents: For Beginners Only. FUNDAMENTAL ANALYSIS. Types of Fundamental Analysis. Analyzing Market Response. A PRACTICAL GUIDE TO REGRESSION ANALYSIS. A Brief Review of Elementary Statistics. Practical Considerations in Applying Regression Analysis. FUNDAMENTAL ANALYSIS APPLIED. Forecasting Currency Rates. TECHNICAL ANALYSIS. Commodity Price Circles. UNDERSTANDING SPREAD TRADING. The Concepts and Mechanics of Spread Trading. Spread Trading in Currency Futures. PRACTICAL TRADING GUIDELINES. Trading Rules and Market Observations. Appendix. Index.
Lyngbyatoxin Biosynthesis:  Sequence of Biosynthetic Gene Cluster and Identification of a Novel Aromatic Prenyltransferase (2004)

The lyngbyatoxins are potent skin irritants produced by Lyngbya majuscula and cause a condition known as "Swimmer's Itch" off Honolulu, HI. Reported is the molecular cloning of the lyngbyatoxin (ltx) biosynthetic gene cluster from L. majuscula using a strategy based on its predicted nonribosomal peptide synthetase (NRPS) assembly. The biosynthetic gene cluster spans 11.3 kilobase pairs and encodes for a two-module NRPS (LtxA), a P450 monooxygenase (LtxB), an aromatic prenyltransferase (LtxC), and an oxidase/reductase protein (LtxD). LtxC was heterologously produced and purified from E. coli and shown to catalyze the transfer of a geranyl group to (-)-indolactam V as the final step in the biosynthesis of lyngbyatoxin A.
Separation and quantitation of free fatty acids and fatty acid methyl esters by reverse phase high pressure liquid chromatography (1983)

Reverse phase high pressure liquid chromatography (HPLC) on octadecylsilyl columns separates mixtures of either free fatty acids or fatty acid methyl esters prepared from mammalian tissue phospholipids. Acetonitrile-water mixtures are used for the elution of esters. Aqueous phosphoric acid is substituted for water for the separation of the free acids. Unsaturated compounds are detected and quantitated by their absorption at 192 nm. Saturates are detected better at 205 nm. The order of elution of fatty acids in complex mixtures varies as a function of acetonitrile concentration. At any given concentration, some compounds overlap. However, by varying the solvent strength, any fatty acid of interest can be resolved including many geometrical and positional isomers. Methyl esters prefractionated according to unsaturation by argentation thin-layer chromatography (TLC) are rapidly and completely separated by elution with CH3CN alone. Argentation TLC-reverse phase HPLC can be used as an analytical as well as a preparative procedure. Octylsilyl columns are used for rapid resolution and improved detection of minor or low ultraviolet-absorbing components in the fractions. For example, monoenoic fatty acids with up to 32 carbons have been detected in bovine brain glycerophospholipids. Specific radioactivities of 3H- and 14C-labeled fatty acids and the distribution of radioactivity among acyl groups from complex lipids are measured. The method is not recommended for complete compositional analysis, but is useful for determinations of specific radioactivities during studies on turnover and metabolic conversions of labeled fatty acids.
Partial tyrosinase‐specific self tolerance by HLA‐A*0201‐restricted cytotoxic T lymphocytes in mice and man (2003)

The human tyrosinase (hTyr) (369-377) cytotoxic T lymphocyte (CTL) epitope is presented by malignant melanoma and various nontransformed cells in association with human leukocyte antigen (HLA)-A*0201 (A2.1) and used for vaccination-based immunotherapy of melanoma patients. Its mouse homologue, mTyr (369-377), is naturally processed and bound by A2.1 with equivalent efficacy and thus enabled us to explore the effect of self tolerance on Tyr-specific T cells in different lines of A2.1 transgenic (Tg) mice and man. We found that self Tyr-reactive CTL in Tg mice and, importantly, in man were affected by partial tolerance resulting in only residual T lymphocytes of higher avidity for self Tyr along with low-avidity T cells to be present in the periphery. Immunizing mice with the xenogeneic nonself Tyr peptide facilitated the generation of self Tyr-reactive CTL. As compared to Tyr-reactive CTL induced by high amounts of the self Tyr epitope, however, the nonself antigen (Ag) had no effect on improving the avidity of self Tyr-specific mouse and human T cells. Depleting mice of CD25(+) T cells with and without CTL-associated Ag 4 (CTLA-4) blockade demonstrated that tolerance of Tyr-specific CTL was not regulated by CD4(+)CD25(+) T regulatory cells (Treg) or CTLA-4. Our studies have important implications for the design of anti-Tyr-based immunotherapeutics.
Computer processing of vertical seismic profile data (1983)

Abstract Vertical seismic profiles (VSP) are a powerful tool in a variety of seismic exploration situations. Only after extensive computer processing of the raw field data, however, can the full value of this tool be realized. With the help of processing, relations between important rock parameters and acoustic properties can sometimes be established and highly reliable ties from well logs to surface seismic profiles can usually be obtained.The basic theory of the processing techniques is well known. However, the techniques used in processing standard surface seismic profiles usually must be modified to adapt them to the unique conditions associated with VSPs.Processing procedures, and their relevance to the interpretation of VSP and surface seismic profile data, are described.
Pulsatile and steady-state hemodynamics of the human patella bone by diffuse optical spectroscopy (2013)

The cardiac cycle related pulsatile behavior of the absorption and scattering coefficients of diffuse light and the corresponding alterations in hemoglobin concentrations in the human patella was studied. The pulsations in scattering is considerably smaller than absorption. The difference in amplitude of absorption coefficient pulsations for different wavelengths was translated to pulsations in oxygenated and deoxygenated hemoglobin, which leads to strong pulsations in the total hemoglobin concentration and oxygen saturation. The physiological origin of the observed signals was confirmed by applying a thigh-cuff. Moreover, we have investigated the optical and physiological properties of the patella bone and their changes in response to arterial cuff occlusion.
Recessed-Gate Enhancement-Mode $\beta $ -Ga2O3 MOSFETs (2017)

We report enhancement-mode <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\beta $ </tex-math></inline-formula> -Ga <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> (BGO) MOSFETs on a Si-doped homoepitaxial channel grown by molecular beam epitaxy. A gate recess process is used to partially remove the epitaxial channel under the 1- <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\mu \text{m}$ </tex-math></inline-formula> gated region to fully deplete at <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">${V}_{\textsf {GS}}= 0$ </tex-math></inline-formula> V. BGO MOSFETs achieve drain current density near 40 mA/mm and <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">${I}_{ \mathrm{\scriptscriptstyle ON}}/{I}_{ \mathrm{\scriptscriptstyle OFF}}$ </tex-math></inline-formula> ratio ~10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">9</sup> which is the highest reported for homoepitaxial normally-off BGO transistors. At <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">${V}_{\textsf {GS}}= \textsf {0}$ </tex-math></inline-formula> V, a breakdown voltage of 198 and 505 V is achieved with the source–drain spacing of 3 and <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$8~\mu \text{m}$ </tex-math></inline-formula> , respectively. The power switching figure of merits for dc conduction and dynamic switch losses meet or exceed the theoretical silicon limit and previously reported depletion-mode BGO transistors.
Development of array‐type prompt gamma measurement system for <i>in vivo</i> range verification in proton therapy (2012)

The results show that the array-type measurement system can measure prompt gamma distributions from a therapeutic proton beam within a short measurement time, and that the distal dose edge can be determined within a few millimeters of error without using any sophisticated analysis.
Isopentenylation of both cytoplasmic and mitochondrial tRNA is affected by a single nuclear mutation. (1982)

Cytoplasmic rRNA from the yeast mutant, mod5-1 is deficient in the modified base isopentenyladenosine and consequently migrates differently from isopentenylated wild type tRNAs on certain chromatographic systems. To determine if the mod5-1 mutation affects mitochondrial tRNA structure, the migration of mitochondrial tRNA from mod5-1 and wild type cells has been compared by reverse-phase chromatography. We conclude from this analysis that the single nuclear mutation that affects the isopentenylation of cytoplasmic tRNA also affects the isopentenylation of mitochondrial tRNA.
New technologies for production of Ferrite cores (1968)

New technologies for producing ferrite memory cores include the incorporation of ferrite powder into sheets with a high binder content; fast multiple tooling presses stamping memory cores out of sheets; cheap high-capacity automated and highly controllable furnaces; and time-saving powder-processing equipment. The combination of processes and equipment meets the needs for increasingly larger numbers of cores, cheaper costs, smaller cores, and higher yields.