gebhart/patrepeval huggingface dataset:
Capacitive Coupling of Atomic Systems to Mesoscopic Conductors (2004)

We describe a technique that enables a strong, coherent coupling between isolated neutral atoms and mesoscopic conductors. The coupling is achieved by exciting atoms trapped above the surface of a superconducting transmission line into Rydberg states with large electric dipole moments that induce voltage fluctuations in the transmission line. Using a mechanism analogous to cavity quantum electrodynamics, an atomic state can be transferred to a long-lived mode of the fluctuating voltage, atoms separated by millimeters can be entangled, or the quantum state of a solid-state device can be mapped onto atomic or photonic states.
Selective Developmental Regulation of Gene Expression for Insulin-like Growth Factor–Binding Proteins in Mouse Spinal Cord (2000)

Both IGFBP-2 and BP-5 are developmentally regulated in mouse spinal cord, with higher levels of those at early embryonic stages indicating their potential role in development of the mouse spinal cord.
Secreted proteins as a fundamental source for biomarker discovery (2012)

The proteins secreted by various cells (the secretomes) are a potential rich source of biomarkers as they reflect various states of the cells at real time and at given conditions. To have accessible, sufficient and reliable protein markers is desirable as they mark various stages of disease development and their presence/absence can be used for diagnosis, prognosis, risk stratification and therapeutic monitoring. As direct analysis of blood/plasma, a common and noninvasive patient screening method, can be difficult for candidate protein biomarker identification, the alternative/complementary approaches are required, one of them is the analysis of secretomes in cell conditioned media in vitro. As the proteins secreted by cells as a response to various stimuli are most likely secreted into blood/plasma, the identification and pre-selection of candidate protein biomarkers from cell secretomes with subsequent validation of their presence at higher levels in serum/plasma is a promising approach. In this review, we discuss the proteins secreted by three progenitor cell types (smooth muscle, endothelial and cardiac progenitor cells) and two adult cell types (neonatal rat ventrical myocytes and smooth muscle cells) which can be relevant to cardiovascular research and which have been recently published in the literature. We found, at least for secretome studies included in this review, that secretomes of progenitor and adult cells overlap by 48% but the secretomes are very distinct among progenitor cell themselves as well as between adult cells. In addition, we compared secreted proteins to protein identifications listed in the Human Plasma PeptideAtlas and in two reports with cardiovascular-related proteins and we performed the extensive literature search to find if any of these secreted proteins were identified in a biomarker study. As expected, many proteins have been identified as biomarkers in cancer but 18 proteins (out of 62) have been tested as biomarkers in cardiovascular diseases as well.
Neutron-treated, ultrafast, photoconductor detectors (1989)

We have investigated homogeneous, photoconductive semiconductors as very fast radiation detectors. We irradiated GaAs, Cr-doped GaAs, and Fe-doped InP crystals with 14 MeV neutrons to produce lattice defects that act as fast recombination centers for electrons and holes. Using short-pulse lasers and 17 MeV linear-accelerator electrons and bremsstrahlung x rays, we measured the temporal response and sensitivity of these photoconductors as functions of fluence ranging from 1012 to 1016 neutrons/cm2. The carrier lifetime and mobility decrease monotonically as the neutron fluence increases, resulting in faster detector response at the expense of sensitivity. A resolving time of less than 30 ps (full width at half maximum) was measured for the above photoconductors irradiated with ∼1015 neutrons/cm2.
An Update on Overcoming MDR1-Mediated Multidrug Resistance in Cancer Chemotherapy (2005)

The intrinsic or acquired resistance to anticancer drugs remains one of the most significant factors impeding the progress of cancer chemotherapy. This phenomenon often involves simultaneous resistance to other anticancer drugs that differ in their chemical structure and mode of action and are not even used in chemotherapy. This phenotype has been called multidrug resistance (MDR). Although the cellular basis underlying MDR is not fully understood, several factors mediating therapy resistance in tumors have been proposed. One of the mechanisms leading to chemoresistance of tumor cells is the increased activity of transporter proteins. The best-characterized transporter protein is MDR1/P-glycoprotein, and a number of clinical investigations have suggested that its intrinsic or acquired overexpression resulted in a poor clinical outcome of chemotherapy. Various types of compounds and techniques for the reversal of MDR1/P-glycoprotein-mediated MDR have been developed, and efforts have concentrated on the inhibition of function and suppression of expression. This review summarizes the current state of knowledge of MDR1/P-glycoprotein and the modulation of MDR by targeting MDR1/P-glycoprotein.
A 3μ CMOS Digital Codec with Programmable Echo Cancellation and Gain Setting (1984)

A 3μ CMOS Digital Signal Processor (DSP) performs speech signal shaping, programmable echo cancellation and gain setting functions for telephone application. A/D and D/A conversions are performed by making use of ΔΣ modulators, decimator and interpolator filter blocks. In addition, the DSP acts as a control interface between the SLIC and the line card controller, the debouncing of eight line status bits included.
The case for a configure-and-execute paradigm (1999)

Article The case for a configure-and-execute paradigm Share on Authors: Frank Vahid Dept. of Computer Science and Eng., Univ. of California, Riverside, CA Dept. of Computer Science and Eng., Univ. of California, Riverside, CAView Profile , Tony Givargis Dept. of Computer Science and Eng., Univ. of California, Riverside, CA Dept. of Computer Science and Eng., Univ. of California, Riverside, CAView Profile Authors Info & Claims CODES '99: Proceedings of the seventh international workshop on Hardware/software codesignMarch 1999 Pages 59–63https://doi.org/10.1145/301177.301211Online:01 March 1999Publication History 22citation160DownloadsMetricsTotal Citations22Total Downloads160Last 12 Months0Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Novel Multiplying Circuits with Application to Electronic Wattmeters (1949)

The primary relationship underlying this investigation is the exponential law relating plate current to plate voltage in a diode when operated in the so-called "retarding-field" region. By extending this classical mode of operation to multigrid tubes, the tube yielded further operating conditions in which plate current is accurately proportional to the product of a linear function of plate voltage and an exponential function of grid voltage over wide ranges. An analysis is given of various multiplying circuits using a single multigrid tube under this mode of operation. Two methods are described for compensating accurately the inherent plate rectification due to the exponential grid curvature. The circuits are most suited for electronic wattmeters having exceptionally good features and predictable performance over the frequency range from 20 cycles up to the neighborhood of 50 Mc.
Morphological and chemical characteristics of anaerobic curved rod-shaped bacteria from the female genital tract. (1984)

Twenty-eight strains of anaerobic curved rod-shaped (ACR) bacteria isolated from the female genital tract were examined and compared with reference strains of Bacteroides, Campylobacter and Wolinella and with 5 anaerobic strains associated with urethritis in male patients. The isolates were received from seven laboratories in Britain and Sweden during the past 12 months. The vaginitis isolates were divided into two groups according to the Gram staining reaction, cell morphology as studied by electron microscopy, biochemical activity tested by conventional and API ZYM tests, electrophoretic mobilities of cellular proteins and chemical compositions of chromosomal DNA. A number of important differences were revealed between the two groups, and between them and allied bacteria. The short Gram-positive (SCR), slightly curved rods had 1 to 3 subterminal lateral flagella and were biochemically more active than the long Gram-negative (LCR) strains, which were more curved and had 3 to 8 flagella. Both ACR groups were different from allied bacteria in their protein profiles and DNA base compositions: the Gram-positive strains had mol%G+C contents of 55.1 +/- 0.6, whereas those of the Gram-negative strains were 53.5 +/- 0.6 mol%. The protein profiles also indicated some heterogeneity within each of the ACR groups. We suggest these ACR strains comprise two distinct species, which are unrelated to the urethritis isolates with G+C contents of 29.9 +/- 0.9 mol% and to the reference strains.
Cost-Effectiveness of Biomarker Screening for Traumatic Brain Injury (2018)

Intracranial hemorrhage after traumatic brain injury (TBI) can be life threatening and requires prompt diagnosis. Computed tomography (CT) scans are a rapid and accurate way to evaluate for hemorrhage. In patients with mild and moderate TBI, however, in whom the incidence of intracranial pathology is low, scanning every patient with CT can be costly. The Food and Drug Administration recently approved a novel biomarker screen, the Banyan Trauma Indicator (BTI), to help streamline the decision for CT scanning in mild to moderate TBI. The BTI screen diagnoses intracranial lesions with a sensitivity and specificity of 97.5% and 99.6%, respectively. We performed cost analyses of the BTI screen to determine the threshold of cost-effectiveness, compared with application of clinical decision rules or routine CT scans, for cases of mild or moderate TBI. With a 0.104 probability of an intracranial lesion in mild TBI, the biomarker screen is cost-effective if the cost is $308.96 or below per test. In moderate TBI, because of the greater prevalence of intracranial lesions at 0.663, there is a lower need for screening, and BTI becomes cost-effective up to $73.41 per test.
CD34 expression by mast cells: of mice and men (2005)

CD34 is a transmembrane protein expressed by vascular endothelial cells and hematopoietic stem/progenitor cells (HSCs),[1][1] but its function has remained obscure. Recently, we observed that in mice, CD34 is highly expressed by committed mast-cell progenitors and their terminally differentiated
Perspective correction for improved visual registration using natural features. (2008)

This research proposes a perspective invariant registration algorithm which improves on popular registration algorithms such as SIFT and SURF by correcting for perspective distortion using optical flow. A novel addition to the natural feature based registration process is proposed, which uses orientation information from previously correctly registered frames to attempt perspective correction. This process is evaluated when applied to the Natural Feature algorithms described. This research overcomes the cause of registration failings based on perspective distortion in Natural Feature Tracking, and attempts to find a better resolution than just pruning invalid matches. The results show that the proposed algorithm improved registration on two prominent Natural Feature based Registration algorithms, SIFT and SURF.
End-to-end Prediction of Driver Intention using 3D Convolutional Neural Networks (2019)

Despite extraordinary progress of Advanced Driver Assistance Systems (ADAS), an alarming number of over 1,2 million people are still fatally injured in traffic accidents every year <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> . Human error is mostly responsible for such casualties, as by the time the ADAS system has alarmed the driver, it is often too late. We present a vision-based system based on deep neural networks with 3D convolutions and residual learning for anticipating the future maneuver based on driver observation. While previous work focuses on hand-crafted features (e.g. head pose), our model predicts the intention directly from video in an end-to-end fashion. Our architecture consists of three components: a neural network for extraction of optical flow, a 3D residual network for maneuver classification and a Long Short-Term Memory network (LSTM) for handling temporal data of varying length. To evaluate our idea, we conduct thorough experiments on the publicly available Brain4Cars benchmark, which covers both inside and outside views for future maneuver anticipation. Our model is able to predict driver intention with an accuracy of 83,12% and 4,07s before the beginning of the maneuver, outperforming state-of-the-art approaches, while considering the inside view only.
Hyperkalemia revisited. (2006)

Hyperkalemia is a common clinical condition that can induce deadly cardiac arrhythmias. Electrocardiographic manifestations of hyperkalemia vary from the classic sine-wave rhythm, which occurs in severe hyperkalemia, to nonspecific repolarization abnormalities seen with mild elevations of serum potassium. We present a case of hyperkalemia, initially diagnosed as ventricular tachycardia, to demonstrate how difficult hyperkalemia can be to diagnose. An in-depth review of hyperkalemia is presented, examining the electrophysiologic and electrocardiographic changes that occur as serum potassium levels increase. The treatment for hyperkalemia is then discussed, with an emphasis on the mechanisms by which each intervention lowers serum potassium levels. An extensive literature review has been performed to present a comprehensive review of the causes and treatment of hyperkalemia.
Exact Focusing of Extracorporeal Shock Wave Therapy for Calcifying Tendinopathy (2002)

A controlled prospective randomized study was designed to analyze the effect of extracorporeal shock wave therapy on calcifying tendinopathy of the shoulder focused on the calcified area or the origin of the supraspinatus tendon. Fifty patients were included in the study and were treated with a Storz Minilith Sl-1 shock wave generator. The first group of patients received 4000 impulses (positive energy flux density, 0.78 mJ/mm2) in two treatment sessions after receiving local anesthesia at the origin of the supraspinatus tendon. Patients in the second group received extracorporeal shock wave therapy at the calcified area. Follow-ups were done 12 weeks and 1 year after treatment by an independent observer. An increase of function and a reduction of pain occurred in both groups. Statistical analyses showed a significant superiority of extracorporeal shock wave application at the calcified area in the primary end point (Constant and Murley score). Therefore, exact fluoroscopic focusing of extracorporeal shock wave therapy at the calcific deposit for treatment of calcifying tendinopathy of the supraspinatus muscle is recommended. Based on these results, extracorporeal shock wave application should be focused fluoroscopically with appropriate shock wave generators.
Next Generation Designed Protein as a Photosensitizer for Biophotovoltaics Prepared by Expanding the Genetic Code (2016)

We explored the possibility of generating nonpoisonous, renewable, low cost and a completely biodegradable photosensitizer for dye-sensitized solar cells (DSSC) as an alternative to synthetic molecules that involve expensive, time-consuming tedious synthesis and purification procedures. Several natural dyes from plants and microbes had successfully been demonstrated as photosensitizers to develop biosensitized solar cells (BSSCs). The objective of this work is to develop a next generation cleaner sensitizer for BSSC using a green fluorescent protein (GFP) and its designer variant (GFPdopa) through an expanding genetic code approach. The designer protein showed higher adsorption with TiO2 surface through oriented immobilization. The nanostructured layer formed by GFPdopa with TiO2 resulted in 0.94% level of photon conversion efficiency with open circuit voltage of 0.60 V, short circuit current of 1.75 mA/cm2 and fill factor of 0.88. It is one of the better energy conversion efficiencies obtained for BSSC when compared to with earlier reported sensitizers generated through protein and chemical complex synergism. From the results obtained, it is suggested that designer fluorescent itself can generate similar photoconversion efficiency and also could serve as an environmental friendly photosensitizer. The research and efficiency level of BSSC is in the early stages, and our proof of principle opens a new avenue to synthesize biologically designer sensitizers for BSSC. It also could be widely applied to other proteins to develop efficient sensitizers for BSSC with a green approach.
Repair and regeneration: experimental aspects of spinal cord disease. (1992)

Regeneration of spinal cord neurons after injury depends on first, the presence of trophic factor(s) which prevent death, induce growth and maintain the viability of the neurone and second, the regenerating neurites must overcome glial scars, extracellular matrices and white matter barriers to reinnervate their target. Attempts at promoting regeneration by using grafts of prosthetic material, Schwann cells and neural tissue have largely been unsuccessful. Although growth could be induced, penetration of regenerating neurites through damaged areas of the spinal cord has been limited. There is as yet very little beneficial functional recovery.
Viral Interference with Antigen Presentation to CD8 <sup>+</sup> T Cells: Lessons from Cytomegalovirus (2005)

Cytomegaloviruses (CMV), in common with other Herpesviruses, establish lifelong persistence in their hosts. These highly host-specific viruses each encode viral genes that interfere with antigen presentation to CD8+ T cells, although the molecular mechanisms by which this end is achieved differ for human and murine CMVs. In each case, there has been a presumption that these genes are necessary for virus persistence in the host. However, recent data in the murine model casts doubt on that presumption. Here, we review the molecular mechanisms of interference with the class I pathway, and the published data regarding functional significance, with a focus on the murine model.
A simple and rapid method for purification of oligodeoxyribonucleoside methylphosphonates. (1993)

An alternative dimethoxytrityl-on (dmt-on) method is described to purify hydrophobic oligodeoxyribonucleoside methyl-phosphonates (OM) with a phosphodiester linkage at the 5' end, instead of the conventional dmt-off method using a DEAE ion-exchange column. This method is modified from the reverse-phase method for purification of normal oligonucleotides.
Percutaneous breast biopsy (1993)

Historical perspectives needle selection the pathologist's perspective nursing considerations the technologist's role principles of stereotactic mammography and quality assurance stereotactic large-core breast biopsy stereotactic biopsy with add-on units stereotactic fine-needle aspiration biopsy introduction to breast ultrasound ultrasound of breast pathology interventional breast ultrasound ultrasound-guided large-core breast biopsy recent and future developments.
Light chain editing generates polyreactive antibodies in chronic graft-versus-host reaction (2006)

The chronic graft-versus-host (cGvH) reaction is a model of induced lupus caused by alloreactive CD4(+) T cells from a Bm-12 mouse in a C57BL/6 recipient. We used this cGvH reaction in C57BL/6 anti-DNA H chain transgenic mice, 56R/B6, to understand the structure, specificity, and origin of the induced autoantibodies (auto-Abs). We found anti-DNA Abs that reacted to several different antigens, such as phosphatidylserine, myelin basic protein, thyroglobulin, histone, insulin, cytochrome C, and beta-galactosidase. This polyreactivity was found for Abs from B cells that expressed the 56R H chain transgene with "editor" L chains that did not completely veto autoreactivity. We suggest that such incomplete editing results in polyreactivity and that incompletely edited polyreactive B cells influence the subsequent expression of pathogenic auto-Abs in disease. We also found B cells that coexpress kappa and lambda L chain. These B cells contributed to the autoimmune response and are possibly in the marginal zone of the spleen.
Identification of two missense mutations in a dihydrolipoamide dehydrogenase-deficient patient. (1993)

The molecular basis of dihydrolipoamide dehydrogenase (E3; dihydrolipoamide:NAD+ oxidoreductase, EC 1.8.1.4) deficiency in an E3-deficient patient was studied. Fibroblasts cultured from the patient contained only approximately 6% of the E3 activity of cells from a normal subject. Western and Northern blot analyses indicated that, compared to control cells, the patient's cells had a reduced amount of protein but normal amounts of E3 mRNA. Direct sequencing of E3 cDNA derived from the patient's RNA as well as each of the subclones of the cDNA revealed that the patient had two substitution mutations in the E3 coding region. One mutation changed a single nucleotide from A to G, resulting in substitution of Glu (GAA) for Lys-37 (AAA). The other point mutation was a nucleotide change from C to T, resulting in the substitution of Leu (CTG) for Pro-453 (CCG). These mutations appear to be significant in that they alter the active site and possibly the binding of FAD.
Symmetric and Dual PRFs from Standard Assumptions: A Generic Validation of an HMAC Assumption. (2015)

The security of HMAC is proven under the assumption that its compression function is a dual PRF, meaning a PRF when keyed by either of its two inputs. But, not only do we not know whether particular compression functions really are dual PRFs, we do not know if dual PRFs even exist. What if the goal is impossible? This paper addresses this with a foundational treatment of dual PRFs, giving constructions based on standard assumptions. This provides what we call a generic validation of the dual PRF assumption for HMAC. Our approach is to introduce and construct symmetric PRFs, which imply dual PRFs and may be of independent interest. We give a general construction of a symmetric PRF based on a function having a weak form of collision resistance coupled with a leakage hardcore function, a strengthening of the usual notion of hardcore functions we introduce. We instantiate this general construction in two ways to obtain a symmetric and dual PRF assuming (1) Any collision-resistant hash function, or (2) Any one-way permutation. A construction based on any one-way function evades us and
Proteolysis of Synaptobrevin, Syntaxin, and Snap‐25 in Alveolar Epithelial Type II Cells (1999)

Synaptobrevin-2, syntaxin-1, and SNAP-25 were identified in rat alveolar epithelial type II cells by Western blot analysis. Synaptobrevin-2 was localized in the lamellar bodies, and syntaxin-1 and SNAP-25 were found in 0.4% Nonidet P40-soluble and -insoluble fractions, respectively, of the type II cells. When the isolated type II cells were stimulated for secretion with calcium ionophore A23187 or with phorbol 12-myristate 13-acetate, these proteins were found to have been proteolyzed. Preincubation of cells with calpain inhibitor II (N-acetylleucylleucylmethionine), however, prevented the proteolysis. Treatment of the cell lysate with exogenous calpain resulted in a time-dependent decrease of these proteins. The data suggest that synaptobrevin, syntaxin, and SNAP-25 are subject to proteolytic modification by activated calpain in intact type II cells stimulated for secretion.