gebhart/patrepeval huggingface dataset:
Recombinant factor VIIa in patients with coagulopathy secondary to anticoagulant therapy, cirrhosis, or severe traumatic injury: review of safety profile (2006)

An important determinant for the safety profile reported here is likely to be the specific mechanism of action of rFVIIa, shown in experimental studies to be localized to the site of vascular injury where tissue factor is exposed.
Analysis of power up and down registration in CMS (CDMA mobile systems) (2002)

the effectiveness of power up and down registration scheme implemented in CDMA mobile systems (CMS) is proved by comparing the system load of registration and paging with a zone based scheme. It is shown that power up and down registration makes the system load lighter and distributed over cells in a location area. It is also shown that power up and down registration makes the system load less sensitive to the traffic and the size of the location area. Also, an optimal size of a location area is suggested which minimizes the bandwidth cost incurred by the registration and paging load.
The involvement of serotonin in the formation of thrombi at critical coronary arterial stenoses in humans (1990)

Animal experiments show a role for serotonin in mediating coronary arterial thrombosis. To test whether this might also be the case in humans, 61 patients with critical coronary artery stenoses shown by coronary angiography were divided into thromboxane-inhibition (30 treated with aspirin) and serotonin-antagonist (31, with ketanserin) groups. They were examined for coronary occlusion until they underwent coronary artery bypass grafting or angioplasty. During this waiting period, 7 of the subjects in the thromboxane-inhibition group had coronary arterial occlusions, and 4 of the 7 died. One occlusion occurred in the serotonin-antagonism group. The probability of the occlusion rate in subjects subjected to thromboxane inhibition and those recieving a serotonin antagonist being the same was less than 0.0245, as measured by Fisher's exact test. The probability of survival from myocardial infarction being the same for the two groups was less than 0.05, as measured by the Mantel-Haentzel test. These results might permit rejection of the null hypothesis for one favoring greater effectiveness of serotonin antagonism, but this conclusion would depend on the two methods adopted. We have therefore adopted the null hypothesis and have concluded that serotonin may be as important in mediating coronary thrombosis in humans as it is in animals.
Connection-oriented Multicasting in Wormhole-switched Networks on Chip (2006)

Network-on-chip (NoC) proposes networks to replace buses as a scalable global communication interconnect for future SoC designs. However, a bus is very efficient in broadcasting. As the system size scales up to explore the chip capacity, broadcasting in NoCs must be efficiently supported. This paper presents a novel multicast scheme in wormhole-switched NoCs. By this scheme, a multicast procedure consists of establishment, communication and release phase. A multicast group can request to reserve virtual channels during establishment and has priority on arbitration of link bandwidth. This multicasting method has been effectively implemented in a mesh network with deadlock freedom. Our experiments show that the multicast technique improves throughput, and does not exhibit significant impact on unicast performance in a network with mixed unicast and multicast traffic if the network is not saturated.
Formation, fragmentation, and isomerization of titanacycle rings supported by aryloxide ligation (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFormation, fragmentation, and isomerization of titanacycle rings supported by aryloxide ligationJohn E. Hill, Phillip E. Fanwick, and Ian P. RothwellCite this: Organometallics 1990, 9, 8, 2211–2213Publication Date (Print):August 1, 1990Publication History Published online1 May 2002Published inissue 1 August 1990https://pubs.acs.org/doi/10.1021/om00158a017https://doi.org/10.1021/om00158a017research-articleACS PublicationsRequest reuse permissionsArticle Views228Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
MV vacuum switchgear based on magnetic actuators (1998)

Vacuum switchgear puts special demands on the operating mechanism, such as a large holding force and impact breaking capability. Characteristics of a permanent magnetic actuator are closer to what is required for vacuum switchgear then those of the usual spring operated mechanism. Application has advantages for simplicity, reliability and controlled switching. Tests prove these statements, for instance by switching 50000 times. Two new ideas are presented in the paper: (1) separating of the magnetic circuits for closing and opening leads to optimisation, larger forces and a more compact actuator; amd (2) application of a new designed permanent magnetic lock makes the closing characteristic to be reproduced very accurately, which can ideally be applied in the case of controlled switching. Tests confirm this feasibility.
Dramatic improvement in mitochondrial cardiomyopathy following treatment with idebenone (2001)

Idebenone, a synthetic analogue of coenzyme Q10, has been shown to improve cardiac function in patients with Friedreich ataxia and a deficiency of respiratory chain complexes I-III. We describe a woman with severe combined right and left heart failure due to a mitochondrial cardiomyopathy. The patient underwent an endomyocardial biopsy as part of an evaluation for cardiac transplantation. It showed severely decreased respiratory complex activities dependent on CoQ, pointing to CoQ depletion. Following idebenone treatment there was a dramatic improvement in her clinical status with resolution of the heart failure.
Fresnel lens in a thin-film waveguide (1978)

The theoretical intensity profile of a phase shift and absorption Fresnel lens in a thin-film waveguide has been calculated. An experimental lens has been constructed with F=5 and a focal length=4 mm using CeO deposited on a BaO waveguide. A 3-dB spot size (full width half-maximum) of 3 μm was obtained compared to a diffraction-limited spot size of 2 μm from theory. Efficiency is approximately 25% and a variation of less than 3 dB in peak intensity is observed over incident angles of up to ±15° from normal.
A Pathogen-Responsive Leucine Rich Receptor Like Kinase Contributes to Fusarium Resistance in Cereals (2018)

Receptor-like kinases form the largest family of receptors in plants and play an important role in recognizing pathogen-associated molecular patterns and modulating the plant immune responses to invasive fungi, including cereal defenses against fungal diseases. But hitherto, none have been shown to modulate the wheat response to the economically important Fusarium head blight (FHB) disease of small-grain cereals. Homologous genes were identified on barley chromosome 6H (<i>HvLRRK-6H</i>) and wheat chromosome 6DL (<i>TaLRRK-6D</i>), which encode the characteristic domains of surface-localized receptor like kinases. Gene expression studies validated that the wheat <i>TaLRRK-6D</i> is highly induced in heads as an early response to both the causal pathogen of FHB disease, <i>Fusarium graminearum</i>, and its' mycotoxic virulence factor deoxynivalenol. The transcription of other wheat homeologs of this gene, located on chromosomes 6A and 6B, was also up-regulated in response to <i>F. graminearum</i>. Virus-induced gene silencing (VIGS) of the barley <i>HvLRRK-6H</i> compromised leaf defense against <i>F. graminearum</i>. VIGS of <i>TaLRRK-6D</i> in two wheat cultivars, CM82036 (resistant to FHB disease) and cv. Remus (susceptible to FHB), confirmed that <i>TaLRRK-6D</i> contributes to basal resistance to FHB disease in both genotypes. Although the effect of VIGS did not generally reduce grain losses due to FHB, this experiment did reveal that <i>TaLRRK-6D</i> positively contributes to grain development. Further gene expression studies in wheat cv. Remus indicated that VIGS of <i>TaLRRK-6D</i> suppressed the expression of genes involved in salicylic acid signaling, which is a key hormonal pathway involved in defense. Thus, this study provides the first evidence of receptor like kinases as an important component of cereal defense against <i>Fusarium</i> and highlights this gene as a target for enhancing cereal resistance to FHB disease.
Cloning and restriction map of the first part of the histidine operon of Salmonella typhimurium (1981)

The first part of the histidine operon of Salmonella typhimurium, hisGpeaGD, has been cloned onto the vector plasmid mini-ColE1 (pVH51). The resulting plasmid, pWB91, has a single EcoRI site and is 11,500 base pairs in size. The HindII restriction map was determined by the method of two-dimensional cross-annealing between a partial digest pattern and a complete digest pattern. The restriction fragment containing the genetic control region was identified with the aid of the small (35-base pair) internal deletion 01242 and the observation that heteroduplexed restriction fragments containing this deletion have markedly reduced mobility on polyacrylamide gels. The genetic control region was then mapped in more detail with other restriction enzymes. The genetic orientation of the restriction map was determined with the aid of several deletions of integral HindII fragments generated in vitro.
E2F1 and E1A(12S) have a homologous activation domain regulated by RB and CBP. (1996)

The E2F1 transcription factor has a well-characterized activation domain at its C terminus and the E1A protein has a recently defined activation domain at its N terminus. Here we show that these activation domains are highly related in sequence. The sequence homology reflects, at least partly, the conservation of common binding sites for the RB and CBP/p300 proteins, which are preserved in the same relative order along E2F1 and E1A. Furthermore, the interaction of RB and CBP with these two activation domains results in the same functional consequences: RB represses both activation domains, whereas CBP stimulates them. We conclude that the activation domains of E1A(12s) and E2F1 belong to a novel functional class, characterized by specific protein binding sites. The implication of this conservation with respect to E1A-induced stimulation of E2F activity is discussed.
Mild Hypothermia as a Cardioprotective Approach for Acute Myocardial Infarction: Laboratory to Clinical Application (2010)

In many animal models, mild therapeutic hypothermia is a powerful intervention, reducing myocardial infarct size, reducing the no-reflow phenomenon, and improving healing after infarction. Cooling in these models has been produced by various means including whole-body hypothermia, synchronized hypothermic coronary venous retro-perfusion, heat exchangers, and regional hypothermia targeting the heart alone. However, in humans, the most widely used techniques are surface cooling and cooling by endovascular heat-exchange catheters. The reduction in temperature necessary to produce cardioprotection is mild (32-34°C), appears to have no detrimental effects on left ventricular function or regional myocardial blood flow, and may improve microvascular reflow to previously ischemic heart tissue. It has been shown in experimental and clinical studies that for therapeutic hypothermia to be effective it must be (1) initiated as early as possible after the onset of ischemia and (2) initiated before reperfusion. This may require initiation of hypothermia in the ambulance, well before mechanical reperfusion occurs. The mechanisms of protection produced by hypothermia have yet to be conclusively determined but may include a decrease in tissue metabolic rate, preservation of high energy phosphates, a reduction in tissue apoptosis or induction of heat shock proteins.
Non-invasive, side-selective nasal airflow monitoring (2005)

Nasal obstruction disturbs comfort during daytime, and sleep quality. Convenient objective assessment of nasal ventilation would be desirable. Therefore, we developed a technique for unobtrusive monitoring of bilateral nasal airflow. Nasal cannulae with separated left- and right-sided tubings were connected to two pressure transducers. Calibration tables were obtained by recording left and right nasal pressures during sequential unilateral nasal occlusion over a few breaths along with airflow by a flow meter attached to a mask. Based on these data, nasal pressures subsequently provided side-selective estimates of airflow without need for a mask. Accuracy of left and right nasal pressure derived airflows was evaluated by comparison of their sum to a flow meter in a bench model, in five volunteers at baseline and during unilateral nasal obstruction by histamine and in five patients during overnight sleep. In the model and volunteers, nasal pressure and flow meter derived flow agreed closely at baseline, and during partial nasal obstruction that altered left/right nasal flow ratios. In patients, nasal pressure derived tidal volumes accurately tracked flow meter estimates over >6 h (70 comparisons, bias -1%, limits of agreement +/-19%). The described method allows continuous, side-selective and unobtrusive monitoring of nasal ventilation for diagnostic evaluation and assessment of treatment effects.
Muscleblind-like 1 suppresses breast cancer metastatic colonization and stabilizes metastasis suppressor transcripts (2016)

Post-transcriptional deregulation is a defining feature of metastatic cancer. While many microRNAs have been implicated as regulators of metastatic progression, less is known about the roles and mechanisms of RNA-binding proteins in this process. We identified muscleblind-like 1 (MBNL1), a gene implicated in myotonic dystrophy, as a robust suppressor of multiorgan breast cancer metastasis. MBNL1 binds the 3' untranslated regions (UTRs) of DBNL (drebrin-like protein) and TACC1 (transforming acidic coiled-coil containing protein 1)-two genes that we implicate as metastasis suppressors. By enhancing the stability of these genes' transcripts, MBNL1 suppresses cell invasiveness. Consistent with these findings, elevated MBNL1 expression in human breast tumors is associated with reduced metastatic relapse likelihood. Our findings delineate a post-transcriptional network that governs breast cancer metastasis through RNA-binding protein-mediated transcript stabilization.
Recovery Guarantees for One-hidden-layer Neural Networks (2017)

In this paper, we consider regression problems with one-hidden-layer neural networks (1NNs). We distill some properties of activation functions that lead to $\mathit{local~strong~convexity}$ in the neighborhood of the ground-truth parameters for the 1NN squared-loss objective. Most popular nonlinear activation functions satisfy the distilled properties, including rectified linear units (ReLUs), leaky ReLUs, squared ReLUs and sigmoids. For activation functions that are also smooth, we show $\mathit{local~linear~convergence}$ guarantees of gradient descent under a resampling rule. For homogeneous activations, we show tensor methods are able to initialize the parameters to fall into the local strong convexity region. As a result, tensor initialization followed by gradient descent is guaranteed to recover the ground truth with sample complexity $ d \cdot \log(1/ε) \cdot \mathrm{poly}(k,λ)$ and computational complexity $n\cdot d \cdot \mathrm{poly}(k,λ) $ for smooth homogeneous activations with high probability, where $d$ is the dimension of the input, $k$ ($k\leq d$) is the number of hidden nodes, $λ$ is a conditioning property of the ground-truth parameter matrix between the input layer and the hidden layer, $ε$ is the targeted precision and $n$ is the number of samples. To the best of our knowledge, this is the first work that provides recovery guarantees for 1NNs with both sample complexity and computational complexity $\mathit{linear}$ in the input dimension and $\mathit{logarithmic}$ in the precision.
Model-Based Decision Making Support in Mobile Service (2007)

With the popularity of mobile device (such as wireless phones, PDAs, etc), many mobile service applications have been developed. However, most current applications focus on information processing. Mobile applications should be extended to decision support. Because of the limitation of mobile devices, the extension can't be archived easily. This paper studies model-based decision support through PDA. Agent-based DSS architecture is proposed. Model formulation and model solving are facilitated by agent collaboration. User accesses the system through user agent in PDA. User agent and interactive agent perform problem understanding interactively. Model formulation agent controls the modeling process. The Agent design is also presented in this paper.
Epigenome rejuvenation: HP1β mobility as a measure of pluripotent and senescent chromatin ground states (2014)

We measured the dynamics of an essential epigenetic modifier, HP1β, in human cells at different stages of differentiation using Fluorescence Recovery After Photobleaching (FRAP). We found that HP1β mobility is similar in human embryonic stem cells (hES) and iPS cells where it is more mobile compared to fibroblasts; HP1β is less mobile in senescent fibroblasts than in young (dividing) fibroblasts. Introduction of "reprogramming factors", Oct4, Sox2, Klf4, cMyc and Lin28, into senescent fibroblasts and measuring the changes in HP1β mobility as reprogramming proceeds shows that the mobility of HP1β in senescent cells increases and by day 9 is the same as that found in young fibroblasts. Thus the dynamics of a key epigenetic modifier can be rejuvenated without de-differentiation through an embryonic stage. Future work will test whether other aspects of cellular physiology that age can be so rejuvenated without de-differentiation.
Pseudomonas (2010)

Introduction Brief Historical Perspective Habitats Morphology and Cellular Structure Pigmentation Fatty-Acid Composition Plasmids Metabolism
Increased risk of non-insulin dependent diabetes mellitus at low plasma vitamin E concentrations: a four year follow up study in men. (1995)

OBJECTIVE--To investigate whether low vitamin E status is a risk factor for incident non-insulin dependent diabetes mellitus. DESIGN--Population based follow up study with diabetes assessed at baseline and at four years. SETTING--Eastern Finland. SUBJECTS--Random sample of 944 men aged 42-60 who had no diabetes at the baseline examination. INTERVENTION--Oral glucose tolerance test at four year follow up. MAIN OUTCOME MEASURES--A man was defined diabetic if he had either (a) a fasting blood glucose concentration > or = 6.7 mmol/l, or (b) a blood glucose concentration > or = 10.0 mmol/l two hours after a glucose load, or (c) a clinical diagnosis of diabetes with either dietary, oral, or insulin treatment. RESULTS--45 men developed diabetes during the follow up period. In a multivariate logistic regression model including the strongest predictors of diabetes, a low lipid standardised plasma vitamin E (below median) concentration was associated with a 3.9-fold (95% confidence interval 1.8-fold to 8.6-fold) risk of incident diabetes. A decrement of 1 mumol/l of uncategorised unstandardised vitamin E concentration was associated with an increment of 22% in the risk of diabetes when allowing for the strongest other risk factors as well as serum low density lipoprotein cholesterol and triglyceride concentrations. CONCLUSIONS--There was a strong independent association between low vitamin E status before follow up and an excess risk of diabetes at four years. This supports the theory that free radical stress has a role in the causation of non-insulin dependent diabetes mellitus.
Quantitative assessment mechanism transcending visual perceptual evaluation for image dehazing (2015)

Quantitative assessment is a core part of the quality evaluation of image dehazing. It is also one of the primary factors that restrict the progress of image dehazing technologies. Because of its high significance in modern information technologies, from both theoretical and practical perspectives, it has attracted increased attention. So what is the quantitative assessment of image dehazing? What are the hurdles associated with it? How to break the bottlenecks in the quantitative assessment of image dehazing? With the present paper, we try to give comprehensive answers to these questions.
SNPs, protein structure, and disease (2001)

Inherited disease susceptibility in humans is most commonly associated with single nucleotide polymorphisms (SNPs). The mechanisms by which this occurs are still poorly understood. We have analyzed the effect of a set of disease-causing missense mutations arising from SNPs, and a set of newly determined SNPs from the general population. Results of in vitro mutagenesis studies, together with the protein structural context of each mutation, are used to develop a model for assigning a mechanism of action of each mutation at the protein level. Ninety percent of the known disease-causing missense mutations examined fit this model, with the vast majority affecting protein stability, through a variety of energy related factors. In sharp contrast, over 70% of the population set are found to be neutral. The remaining 30% are potentially involved in polygenic disease.
An investigation of dose titration with darifenacin, an M <sub>3</sub> ‐selective receptor antagonist (2005)

Darifenacin appears to be an effective, well-tolerated and flexible treatment for patients with OAB, allowing individualized dosing according to patient needs.
Biodiesel research progress 1992-1997 (1998)

The US Department of Energy (DOE) Office of Fuels Development began evaluating the potential of various alternative fuels, including biodiesel, as replacement fuels for traditional transportation fuels. Biodiesel is derived from a variety of biological materials from waste vegetable grease to soybean oil. This alkyl ester could be used as a replacement, blend, or additive to diesel fuel. This document is a comprehensive summary of relevant biodiesel and biodiesel-related research, development demonstration, and commercialization projects completed and/or started in the US between 1992 and 1997. It was designed for use as a reference tool to the evaluating biodiesel`s potential as a clean-burning alternative motor fuel. It encompasses, federally, academically, and privately funded projects. Research projects are presented under the following topical sections: Production; Fuel characteristics; Engine data; Regulatory and legislative activities; Commercialization activities; Economics and environment; and Outreach and education.
A new method for the determination of aortic pulse wave velocity using cross‐correlation on 2D PCMR velocity data (2008)

2D-XC is a more reproducible method than either the established TT or FOOT methods to estimate the aortic PWV.