gebhart/patrepeval huggingface dataset:
Serum adiponectin is a negative predictor of incident metabolic syndrome: a population-based 2.5-year follow-up study (2011)

Objective: Growing evidence suggests that increased adiponectin levels may play a protective role in the development of metabolic syndrome (MetS). We investigated whether increased serum adiponectin is a negative predictor of incident MetS in a population-based longitudinal study in Korea. Methods: We analyzed data from 2,675 adults (1,250 men and 1,425 women) without MetS, aged 40 to 70 years assessed in the Korean Genome and Epidemiology Study on Atherosclerosis Risk of Rural Areas in Korean General Population (KoGES-ARIRANG). MetS was defined according to the National Cholesterol Education Program Adult Treatment Panel III report and the World Health Organization Asian Pacific Guideline. Results: During an average of 2.5 years of follow-up, MetS was developed in 413 men and 425 women. The median adiponectin levels at baseline in subjects who developed MetS were significantly lower than those who did not in men and women. The highest quartile of adiponectin level in men (≥10.21 μg/mL) were associated with significantly decreased risk of new-onset MetS (HR, 0.30; 95% CI, 0.21-0.43) as well as all components of MetS after adjustment for age, smoking, alcohol intake, exercise and HOMA-IR. The highest quartile of adiponectin level in women (≥14.40 μg/mL) were also associated with decreased risk of new-onset MetS (HR, 0.27; 95% CI, 0.19-0.38) as well as all components of MetS. Conclusion: Our findings suggest that increased serum adiponectin could be a negative predictor of incident MetS and its components.
Antibody as an immunological probe for studying the refolding of bovine serum albumin. An immunochemical approach to the identification of possible nucleation sites. (1978)

Specifically purified antibody to either domain I, domain III, or to subregions of domains I or III of serum albumin was added to refolding mixtures containing reduced serum albumin but no other refolding catalyst. It was found that the refolding of reduced albumin was greatly enhanced by the presence of specific antibody in the refolding mixture, that this enhancement was restricted to that domain for which the added antibody was directed, and that antibody-mediated enhancement of refolding in the NH2-terminal portion of each domain was delayed as compared to that seen in the COOH-terminal portion of each domain. Thus, an apparent COOH-terminal to NH2-terminal pathway of refolding within each domain was observed, which is consistent with the proposed evolutionary pathway of the albumin molecule and also consistent with the proposed presence of a nucleation center in the COOH-terminal double disulfide loop of each domain.
Expression of IFN-<i>alpha</i> and IFN-<i>gamma</i> receptors on normal human small resting T lymphocytes and large granular lymphocytes. (1986)

The expression of interferon (IFN) receptors was studied on freshly isolated human lymphocytes from normal donors. Highly enriched populations of small resting T lymphocytes and large granular lymphocytes (LGL) were found to constitutively express high-affinity receptors for IFN-alpha and IFN-gamma. Both types of lymphocytes also had lower-affinity IFN-alpha binding sites. T lymphocytes had a mean of 230 IFN-alpha and 520 IFN-gamma high-affinity receptors per cell, whereas LGL had 520 IFN-alpha and 760 IFN-gamma receptors. However, because LGL were larger than the T lymphocytes, the IFN receptor density was similar on the two types of lymphocytes. The affinity of binding was similar on the two types of normal lymphocytes and on the cultured lymphoblastoid cell line Daudi. The number of IFN receptors per cell and the affinities of the IFN-receptor interactions varied little among the normal donors. Both the freshly isolated normal lymphocytes and the cultured cell line Daudi had separate receptors for type I (alpha and beta) and type II (gamma) IFN. Taken together, our data indicate that two types of freshly isolated normal lymphocytes constitutively express IFN receptors that are similar to those present on the lymphoblastoid cell line Daudi derived from a patient with Burkitt's lymphoma.
Reining in Medicaid Spending-States Respond to Declining Revenues (2002)

Medical care, Cost of; Medicare
Role of insulin autoantibody affinity as a predictive marker for type 1 diabetes in young children with HLA‐conferred disease susceptibility (2009)

Among young IAA-positive children with HLA-conferred disease susceptibility IAA affinity failed to distinguish rapid progressors from slowly or non-progressing subjects. In relation to IAA affinity, no maturation of the humoral immune response was observed over time from seroconversion to diagnosis.
Low Power Transmitter Design for BAN (2007)

This paper presents a low power, low cost, high integrated transmitter front-end designed for the body area network sensor nodes working at the 2.4 GHz Industry-Science- Medical (ISM) band. Baseband LPF, quadrature up-mixer, differential driver amplifier and T/R switch are designed and implemented in 0.18μm RF CMOS technology. The RC networks based single amplifying block style LPF, modified active up- mixer and two-stage driver amplifier are adopted for large signal processing and low signal distortion. The transmitter outputs OdBm power, with 16dB gain and 8.5dBm 0-IP3, consuming 6mA from 1.8V power supply.
Spatially controlled surface immobilization of nucleophiles via trapping of photo-generated thioaldehydes (2013)

A novel and very simple photochemical strategy that utilizes light as a facile means to provide spatio-temporal control for the direct covalent immobilization of nucleophiles is presented. The concept is based upon the efficient trapping of photogenerated thioaldehydes by amines, hydroxylamines, and thiols. Surface patterns of polymers and small molecules bearing pendant amine-, hydroxylamine- or thiol moieties were successfully generated and imaged in a time-of-flight secondary-ion mass spectrometry (ToF-SIMS) investigation.
X-Ray and Electron Microscopic Study of a High Temperature Superconductor Y<sub>0.4</sub>Ba<sub>0.6</sub>CuO<sub>2.22</sub> (1987)

A superconducting oxide Y 0.4 Ba 0.6 CuO 2.22 with T c higher than 88 K was synthesized. The crystal structure was found to be a derivative of the perovskite structure with orthorhombic unit cell dimensions of a =3.818 (1) Å, b =3.888 (1) Å, c =11.667 (4) Å, and V =173.19 (8) Å 3 . Basic unit cell of the cubic perovskite structure was tripled along the c axis, probably due to the ordering of Y 3+ and Ba 2+ ions and/or of oxygen vacancy. Apparent short bond length for Cu-O may partly be explained by oxygen vacancy amounting to a quarter, but the observed high T c suggests actual contraction of Cu-O bonds.
Emerging complexities of APOBEC3G action on immunity and viral fitness during HIV infection and treatment (2012)

The enzyme APOBEC3G (A3G) mutates the human immunodeficiency virus (HIV) genome by converting deoxycytidine (dC) to deoxyuridine (dU) on minus strand viral DNA during reverse transcription. A3G restricts viral propagation by degrading or incapacitating the coding ability of the HIV genome. Thus, this enzyme has been perceived as an innate immune barrier to viral replication whilst adaptive immunity responses escalate to effective levels. The discovery of A3G less than a decade ago led to the promise of new anti-viral therapies based on manipulation of its cellular expression and/or activity. The rationale for therapeutic approaches has been solidified by demonstration of the effectiveness of A3G in diminishing viral replication in cell culture systems of HIV infection, reports of its mutational footprint in virions from patients, and recognition of its unusually robust enzymatic potential in biochemical studies in vitro. Despite its effectiveness in various experimental systems, numerous recent studies have shown that the ability of A3G to combat HIV in the physiological setting is severely limited. In fact, it has become apparent that its mutational activity may actually enhance viral fitness by accelerating HIV evolution towards the evasion of both anti-viral drugs and the immune system. This body of work suggests that the role of A3G in HIV infection is more complex than heretofore appreciated and supports the hypothesis that HIV has evolved to exploit the action of this host factor. Here we present an overview of recent data that bring to light historical overestimation of A3G's standing as a strictly anti-viral agent. We discuss the limitations of experimental systems used to assess its activities as well as caveats in data interpretation.
Impact of actively body-bias controlled (ABC) SOI SRAM by using direct body contact technology for low-voltage application (2004)

Actively Body-bias Controlled (ABC) SOI SRAM that has a new cell structure including connections of the access and the driver transistor's bodies to the word line is proposed to realize low-voltage operation. We developed the direct body contact technology to apply forward biases to the bodies without area penalties and increases of parasitic gate capacitances by using the hybrid trench isolation for the first time. Moreover, the standby current does not change because the body bias is not applied when the word-line voltage is low level. It is successfully demonstrated that low-voltage and high-speed operation is achieved by using the ABC SOI SRAM.
Compact Countercurrent Distribution Apparatus (1958)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCompact Countercurrent Distribution ApparatusSamuel. RaymondCite this: Anal. Chem. 1958, 30, 7, 1214–1216Publication Date (Print):July 1, 1958Publication History Published online1 May 2002Published inissue 1 July 1958https://doi.org/10.1021/ac60139a010Request reuse permissionsArticle Views24Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (393 KB) Get e-Alertsclose Get e-Alerts
Antisense Inhibition of Bax mRNA Increases Survival of Terminally Differentiated HL60 Cells (1998)

Cell sensitivity to programmed cell death is primarily modulated by members of the Bcl-2 family, as the balance of homodimer or heterodimer formation between proapoptotic and antiapoptotic members defines apoptosis susceptibility in the great majority of cellular contexts. It is, therefore, important to clarify if the Bax protein is limiting for activation of the genetic program of programmed cell death or can be complemented by different Bcl-2 family members, such as Bak or Bad. To gain some insight into the role of Bax in the molecular mechanisms of apoptosis of myeloid cells, we inhibited this gene in all-trans-retinoic acid (ATRA)-treated HL60 cells using the methodology of antisense oligodeoxynucleotides (AS-ODN). Our results indicate that Bax inhibition has no effect on the proliferation and differentiation capacity of HL60 cells. Instead, the survival rate of terminally differentiated Bax-inactivated HL60 (Bax(-) HL60) cells is almost three times higher in respect to control cultures, indicating that in mature granulocytes Bax is not efficiently complemented by others members of the Bcl-2 family proteins.
100 years young (2013)

Marjorie Henson a resident at Tancred Hall Care Centre near Whixley, celebrated her 100th Birthday with Family and Staff on Saturday 28th October ...
The Role of Context in m-Commerce and the Personalization Dimension (2006)

The rapid development of mobile devices contributed to the introduction of m-commerce whose growth is expected to exceed that of e-commerce. The interface usability of mobile applications is a critical factor for the acceptance of m-commerce, as a good interface design allows users achieve high performance when using mobile applications. However, this it is especially difficult to achieve due to certain limitations of mobile devices; limited processing power, low-bandwidth communication, small display and overall device size, limited mobile Internet coverage, delays in standardization and poor quality of service. In this paper, we discuss the particular characteristics of the mobile setting, survey available design guidelines and stress the crucial role personalization can play for alleviating the aforementioned problems and allowing m-commerce reach its full potential
KP model for hysteresis of piezoelectric ceramic actuators (2015)

The hysteresis characteristic is exhibited in piezoelectric ceramic actuators. For the purpose of describing the hysteresis characteristic between input voltage and output displacement of piezoelectric ceramic actuators, a modeling method based on Krasnosel'skii-Pokrovskii model is adopted in this paper. The density function of the Krasnosel'skii-Pokrovskii model is identified by cuckoo search algorithm and hybrid optimization algorithm of particle swarm and cuckoo search. The simulation results show that the maximum displacement error is 0.29μm when the density function is identified by cuckoo search algorithm and the maximum displacement error is 0.22μm when the density function is identified by hybrid optimization algorithm of particle swarm and cuckoo search. By comparing two identification methods above, it can be seen that the Krasnosel'skii-Pokrovskii model identified by hybrid optimization algorithm can accurately describe the hysteresis characteristic of piezoelectric ceramic actuators.
what the journals say (2008)

The literature to date explores the development of biological agents that could improve outcomes for metastatic disease, while minimizing toxicity to the patient with colorectal cancer. Here, the authors review the use of bevacizumab in patients with metastatic colorectal cancer and discuss aspects related to how it acts upon the tumour, therapy dosage, administration and management of potential side−effects.
The Micro Check-in Framework for the Next Generation of Location-based Applications (2012)

Today's mobile computing platforms provide new, convenient possibilities for location-based commercial activity. In particular, the global positioning system (GPS) provides location data for local advertising and retail activity. In this thesis, we take the next step and introduce the concept of micro check-in. Micro check-in is a simple framework that allows users to match their current location to specific objects or places at a resolution much finer than that allowed by GPS based check-in. We show that micro check-in enables customers to reveal their location at a fine level of granularity. By describing the concepts of points of service, service providers, users, and the enabling technology, we present a generalized, abstract, framework for designing, developing, and analyzing micro check-in based systems. We discuss several new applications that open up as a result of the combination of real-life and digital communication channel as a result of the micro check-in process. For example, micro check-in could prove quite useful to customers at a restaurant table, a gym equipment station, an exhibit at a museum and many more. This thesis studies micro check-in applied to the process of ordering food from a table at a restaurant and present the beneficial tradeoffs enabled by micro check-in. We find that the micro check-in framework has promising applications in several areas, but specifically utilize the restaurant application, OnTable, to prove the potential use of the micro check-in framework.
Successful treatment of transplant-associated microangiopathy with rituximab. (2009)

The microangiopathic anaemia with thrombocytopenia--which can occur after haematopoietic stem cell transplant--resembles thrombotic thrombocytopenic purpura but has different pathophysiology and does not respond to plasma exchange. We describe a patient with severe manifestations of this disorder who recovered promptly following treatment with rituximab, an anti-CD20 antibody.
Modeling of Five-Level Converter Used in a Synchronous Rectifier Application (2006)

In this paper it is presented a modeling process of a five-level neutral point clamped converter used in a synchronous rectifier application and the resulting model that describes the dynamics for such converter. The highly nonlinear model, originally in abc-coordinates, is also expressed in its alphabetagamma-coordinates. Special attention is given to the gamma-component of the control input, which represents a degree of freedom that can be used for the balancing of the capacitors voltages. It is shown that the sum of capacitors voltages is a natural state of the system since it is necessary to control the total voltage on the DC side and, indeed, it reduce considerably the model expression which describes the dynamics of that voltage. It is also shown that the controller gamma-component has a minimum influence on the sum of the capacitors voltages, but it has a strong influence on the difference, hence its importance in the capacitors voltages balance. Simulations are presented to validate the proposed model. This new modeling approach and resulting model it is expected to stimulate new control proposals in the future
A Reference Model for Online Learning Communities (2002)

Abstract: Online learning communities are introduced as a comprehensive model for technology-enabled learning. We give an analysis of goals in education and the requirements to community platforms. The main contribution of the paper is a reference model for online learning communities that consists of four layers designing the organizational, interaction, channel or service and the technological model of learning communities. This reference model captures didactic goals, learning methods and learning platforms in a structured way and provides guidelines on how to design and implement a medium for learning.
Influences of vestibular and visual motion information on the spatial firing patterns of hippocampal place cells (1995)

Hippocampal place cells show location-specific firing as animals locomote in an environment. A possible explanation for these place fields is that each cell is simply driven by environmental sensory inputs available in its field. This cannot provide the full explanation, however, since cells can maintain stable place fields even in the absence of reliable environmental orienting cues. This suggests the cells are also influenced by movement-related information, since this is the only available, ongoing indicator of current location when external orienting cues are not present. Two candidates for the movement-related information are vestibular activation, and visual motion. To test for these influences, place cells were recorded as animals locomoted in a cylindrical apparatus that was made so that its wall (painted with vertical black and white stripes) and floor could be independently rotated, to provide visual motion and vestibular inputs, respectively. The results showed that both these inputs could influence place fields. Sometimes they caused a predictable locational shift, so that the field rotated its location on the apparatus floor in a way that was compatible with the movement indicated by the vestibular and/or visual motion input. This updating was most reliably obtained when the two inputs were presented in combination. In other cases, the apparatus rotations caused unpredictable changes in firing characteristics, so that cells either stopped firing, or developed place fields that were altered in overall size, shape, and eccentricity. Interestingly, the probability of these changes increased with experience with the rotational manipulations, suggesting a learned component.
Cycloheximide Is Not a Specific Inhibitor of Protein Synthesis <i>in Vivo</i> (1975)

Cycloheximide is frequently presumed to inhibit specifically the cytoplasmic protein synthesis of eukaryotes. Although previous investigators have shown that it had other effects on the cells of a variety of organisms, these results were frequently presumed to be secondary effects of the inhibition of protein synthesis. This paper shows that a wide range of deleterious effects are produced by cycloheximide on a single organism, Chlamydomonas reinhardi Dangeard. If, protein synthesis is inhibited by nonpermissive conditions in temperature-sensitive mutants or with other treatments these "secondary" effects are not produced. Instead, cycloheximide appears to have two or three independent inhibitory effects on the cell. Moreover, in contrast to a number of previous investigations, these results show that protein synthesis is not required for RNA synthesis. Instead the rate of RNA synthesis is actually increased by interference with protein synthesis.
Polydiacetylene paper-based colorimetric sensor array for vapor phase detection and identification of volatile organic compounds (2012)

Detection and identification of VOCs in their vapor phase is essential for safety and quality assessment. In this work, a novel platform of a paper-based polydiacetylene (PDA) colorimetric sensor array is prepared from eight diacetylene monomers, six of which are amphiphilic and the other two are bolaamphiphilic. To fabricate the sensors, monomers are coated onto a filter paper surface using the drop-casting technique and converted to PDAs by UV irradiation. The PDA sensors show solvent induced irreversible color transition upon exposure to VOC vapors. When combined into a sensing array, the color change pattern as measured by RGB values and statistically analyzed by principal component analysis (PCA) is capable of distinguishing 18 distinct VOCs in the vapor phase. The PCA score and loading plots also allow the reduction of the sensing elements in the array from eight to three PDAs that are capable of classifying 18 VOCs. Utilizing an array containing only two PDAs, various types of automotive fuels including gasoline, gasohol and diesel are successfully classified.
Configuration management in a heterogeneous target environment (2003)

A description is given of a system for software configuration management of a distributed application written using several programming languages and modern software engineering techniques. The project has a heterogeneous target environment consisting of multiple microprocessor types and operating systems. The authors present the configuration management system by describing its goals, major tools, their databases and algorithms and the procedures for their use. The software configuration management system described was developed to cope with large, microprocessor-based distributed computing systems. Such systems are based on modern forms of software structure supporting 'programming in the large'. They execute in a heterogeneous environment, consisting of multiple processors, operating systems and programming languages. This type of target environment, which is characteristic of embedded software systems, is becoming increasingly more common.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>