gebhart/patrepeval huggingface dataset:
Differential Signaling to Apoptotic and Necrotic Cell Death by Fas-associated Death Domain Protein FADD (2004)

Two general pathways for cell death have been defined, apoptosis and necrosis. Previous studies in Jurkat cells have demonstrated that the Fas-associated death domain (FADD) is required for Fas-mediated signaling to apoptosis and necrosis. Here we developed L929rTA cell lines that allow Tet-on inducible expression and FK506-binding protein (FKBP)-mediated dimerization of FADD, FADD-death effector domain (FADD-DED), or FADD-death domain (FADD-DD). We show that expression and dimerization of FADD leads to necrosis. However, pretreatment of the cells with the Hsp90 inhibitor geldanamycin, which leads to proteasome-mediated degradation of receptor interacting protein 1 (RIP1), reverts FKBP-FADD-induced necrosis to apoptosis. Expression and dimerization of FADD-DD mediates necrotic cell death. We found that FADD-DD is able to bind RIP1, another protein necessary for Fas-mediated necrosis. Expression and dimerization of FADD-DED initiates apoptosis. Remarkably, in the presence of caspase inhibitors, FADD-DED mediates necrotic cell death. Coimmunoprecipitation studies revealed that FADD-DED in the absence procaspase-8 C/A is also capable of recruiting RIP1. However, when procaspase-8 C/A and RIP1 are expressed simultaneously, FADD-DED preferentially recruits procaspase-8 C/A.
Handbook of Solubility Data for Pharmaceuticals (2009)

Aqueous solubility is one of the major challenges in the early stages of drug discovery. One of the most common and effective methods for enhancing solubility is the addition of an organic solvent to the aqueous solution. Along with an introduction to cosolvency models, the Handbook of Solubility Data for Pharmaceuticals provides an extensive datab
Three-dimensional contrast-enhanced moving-bed infusion-tracking (MoBI-track) peripheral MR angiography with flexible choice of imaging parameters for each field of view (2000)

A technique to image peripheral arteries with flexible choice of scan parameters for separate stations was developed based on moving-bed single-bolus three-dimensional gradient-recalled echo magnetic resonance angiography. A volunteer study yielded higher signal- and contrast-to-noise ratios, less venous enhancement, and better subjective interpretability compared with imaging with fixed parameters for each station. Additionally, six patients were imaged to test the feasibility of the new method in a clinical setting. Imaging peripheral arteries with the new technique in volunteers yielded better image quality and is feasible for patients.
Surface and interfacial tensions of polymer melts. II. Poly(methyl methacrylate), poly(n-butyl methacrylate), and polystyrene (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSurface and interfacial tensions of polymer melts. II. Poly(methyl methacrylate), poly(n-butyl methacrylate), and polystyreneSouheng WuCite this: J. Phys. Chem. 1970, 74, 3, 632–638Publication Date (Print):February 1, 1970Publication History Published online1 May 2002Published inissue 1 February 1970https://pubs.acs.org/doi/10.1021/j100698a026https://doi.org/10.1021/j100698a026research-articleACS PublicationsRequest reuse permissionsArticle Views3159Altmetric-Citations368LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Content-Adaptive Interpolation for Spatial Error Concealment (2009)

When transmitting encoded images over a communication channel, the reconstructed image quality can be substantially degraded by channel errors. This paper presents a spatial error concealment algorithm that utilizes variance of surrounding pixels, and then classifies each error block (EB) into two categories: uniform block and edge block. For uniform block, nearest border prior spatial interpolation is adopted to restore missing pixels. We use the Wiener interpolation algorithm and special interpolation sequence for edge block. Experimental results indicate the proposed algorithm can attain well restored quality of intra-frames both subjectively and objectively. Meanwhile, the computational cost of the proposed algorithm can be significantly reduced, compared to Lipsilas method. And the restored quality is almost the same, sometimes even much better.
Toward an enhanced understanding and implementation of photopolymerization reactions (2008)

Abstract Photopolymerization reactions proceed rapidly at ambient conditions and are able to exhibit both temporal and spatial control, nevertheless their full potential has been limited by a lack of understanding of the polymerization kinetics and polymer network evolution as well as a lack of custom, functional monomers, and polymerization mechanisms. For the last 15 years, our group has sought to address these limitations by reaction engineering at both the fundamental and applied levels with a focus on increasing the understanding, potential, and implementation of photopolymerization reactions. In particular, we have modeled and experimentally validated the complex spatially dependent polymerization kinetics and network heterogeneity, and we have implemented these systems for applications improvement or development in lithography, microdevice fabrication, biomaterials, biodetection, dental materials, and surface coatings. © 2008 American Institute of Chemical Engineers AIChE J, 2008
Visualizing Network Flows and Related Anomalies in Industrial Networks using Chord Diagrams and Whitelisting (2016)

Industrial Control Systems are the set of specialized elements that monitor and control physical processes. Those systems are normally interconnected forming environments known as industrial networks. The particularities of these networks disallow the usage of traditional IT security mechanisms, while allowing other security strategies not suitable for IT networks. As industrial network traffic flows follow constant and repetitive patterns, whitelisting has been proved a viable approach for anomaly detection in industrial networks. In this paper, we present a network flow and related alert visualization system based on chord diagrams. The system represents the detected network flows within a time interval, highlighting the ones that do not comply the whitelisting rules. Moreover, it also depicts the network flows that, even if they are registered in the whitelist, have not been detected on the selected time interval (e.g. a host is down). Finally, the visualization system is tested w ith network data coming from a real industrial network.
Deterministic Skip Lists in Analog Topological Placement (2006)

This paper presents a novel algorithm for device-level analog placement with symmetry constraints. Based on the exploration of symmetric-feasible (S-F) binary tree representations (Balasa et al., 2004) of the layout, the novel approach employs 1-3 deterministic skip lists (Munro et al., 1992) and (Papadakis, 1993), exhibiting running times at least 20-30% better than previous (nonslicing) topological algorithms for analog placement, and significantly better (typically, over 100%) than more traditional approaches based on the absolute representation.
Optimizing Perforating Charge Design for Stimulation (2012)

Abstract Hydraulic stimulation technologies, which are vital in maximizing the production of unconventional reservoirs, have typically focused on pumping capacities and rates, hydraulic fluid viscosities, and proppant materials. A technology that historically has been overlooked, but is critical to an efficient hydraulic stimulation, is the actual perforations through which the treatment is pumped. Fundamental rock and fracture mechanics demonstrate that perforation shot density, phasing, and hole size affect breakdown and treating pressures and injection rates, and can be a cause of early screenout. Although some of these perforation parameters are considered in the best practices, perforation hole size is often misunderstood. Complex computer fracture models, used to plan stimulation and completion programs, often incorporate average holediameter values with little consideration of the actual hole sizes or the variance from shot to shot. New research documents how this inconsistency can be considerable when using standard shaped-charge perforators. Nevertheless, perforating charges designed for natural completions, which focus primarily on the depth of penetration, are continuously used before hydraulic stimulation, ignoring the importance of consistent hole size. Advanced simulations using finite element analysis (FEA) have confirmed that fracture placement in a reservoir requiring stimulation would benefit significantly from maintaining consistency in the size of the perforation exit-hole. This work reviews the analysis performed and the subsequent successful field results for a new class of shaped-charge. The new fracture charge is engineered to maximize hole-diameter while maintaining a consistent exit-hole diameter independent of well profile and/or gun eccentricity. Designed for perforating before a hydraulic stimulation, a fracture charge has been shown to optimize fracturing efficiency and placement by ensuring that each perforation tunnel contributes equally during the fracture treatment, which contributes to providing cost effective hydraulic stimulation and maximizing subsequent asset value.
CVL: A C Vector Library Manual, Version 2 (1993)

CVL is a library of low-level vector routines callable from C. This library includes a wide variety of vector operations such as elementwise function applications, scans, reduces and permutations. Most CVL routines are defined for segmented and unsegmented vectors. This paper is intended for CVL users and implementors, and assumes familiarity with vector operations and the scan-vector model of parallel computation.
High power time domain measurement system with active harmonic load-pull for high efficiency base station amplifier design (2002)

A measurement system combining vector corrected waveform measurements with active harmonic load-pull extends, for the first time, real-time experimental waveform engineering up to the 30 W power level. This novel harmonic load-pull approach is demonstrated on a 4 W LDMOS device. A 20% increase in maximum output power to 4.7 W without degrading gain and efficiency was realized.
General Media (1974)

Robert V. Bruce's Bell: Alexander Graham Bell and the Conquest of Solitude (Boston: Little, Broan, 1973---12.50) Wilbur Schramm, Men, Messages, and Media: A Look at Human Communication (New York: Harper & Row, 1975---$3.95, paper) Herbert I. Schiller's The Mind Managers (Boston: Beacon Press, 1973---$9.95) W.O.G. Lufts and Derek Adley's The Saint and Leslie Charteris (Bowling Green, Ohio: Bowling Green University POpular Press, 1972---$4.00/2.00) Walter E. Hurst and William Storm Hale's The Record Industry Book: How to Make Money in the Record Industry, Volume I (Hollywood: 7 Arts Press, 6430 Sunset Blvd., 1971---$25.00) The Mimic Industry Book:. How to Make Money in the Music Industry, Volume II (same publication and price as above)
Release of newly synthesized platelet-activating factor (PAF) from human polymorphonuclear leukocytes under in vivo conditions. Contribution of PAF-releasing factor in serum (1992)

The behavior of platelet-activating factor (PAF) produced in stimulated human polymorphonuclear leukocytes (PMN) was investigated in the presence of serum under conditions close to those existing in vivo. When the cells were stimulated in the presence of the serum obtained from a PAF acetylhydrolase (PAF-AH)-deficient Japanese subject, over 60% of synthesized PAF was detected in the extracellular medium by bioassay, scintillation proximity RIA and selected ion monitoring/gas chromatography/mass spectrography analysis. The release of PAF from PMN after stimulation with FMLP and A23187 was also observed in the presence of normal serum treated with acid to inactivate PAF-AH. The heterogeneity of the molecular species of extracellular PAF was similar to that of intracellular PAF produced in stimulated PMN in the presence of PAF-AH-deficient serum, ruling out the possibility that a specific molecular species of PAF was preferentially released from the cells in the presence of the serum. As these data suggested the occurrence of PAF-releasing factor(s) in the serum, an attempt was made to partially purify this factor from PAF-AH-deficient serum and acid-treated normal serum by ammonium sulfate fractionation and column chromatography with DEAE-Cellulofine and Sepharose CL-6B. The molecular mass of PAF-releasing factor revealed on a TSK gel G3000 SW HPLC column was 240 kDa, which was different from that of albumin. The binding assay, newly developed for this study, revealed that the PAF-binding activity of PAF-releasing factor is stronger than that of albumin, and that the PAF-releasing factor forms a complex with PAF at low concentration (10(-9) M). PAF bound to this factor was difficult to be hydrolyzed by serum PAF-AH. On the other hand, the PAF/PAF-releasing factor complex had aggregatory activity toward washed rabbit platelets. These observations suggest that certain protein(s) releases and carries the PAF newly synthesized by PMN in blood plasma/serum. Thus it appears that PAF functions as an autacoid in vivo, along with other mediators.
A 1.65mW 0.16mm2 dynamic zoom-ADC with 107.5dB DR in 20kHz BW (2016)

Audio codecs for automotive applications and smartphones require up to five stereo channels to achieve effective acoustic noise and echo cancellation, thus demanding ADCs with low power and minimal die area. Zoom-ADCs should be well suited for such applications, since they combine compact and energy-efficient SAR ADCs with low-distortion ΔΣ ADCs to simultaneously achieve high energy efficiency, small die area, and high linearity [1,2]. However, previous implementations were limited to the conversion of quasi-static signals, since the two ADCs were operated sequentially, with a coarse SAR conversion followed by, a much slower, fine ΔΣ conversion. This work describes a zoom-ADC with a 20kHz bandwidth, which achieves 107.5dB DR and 104.4dB SNR while dissipating 1.65mW and occupying 0.16mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . A comparison with recent state-of-the-art ADCs with similar resolution and bandwidth [3-7] shows that the ADC achieves significantly improved energy and area efficiency. These advances are enabled by the use of concurrent fine and coarse conversions, dynamic error-correction techniques, and an inverter-based OTA.
Fenofibrate, a peroxisome proliferator‐activated receptor α agonist, reduces hepatic steatosis and lipid peroxidation in fatty liver Shionogi mice with hereditary fatty liver (2006)

Fenofibrate, which is currently used in therapy of hyperlipidemia, might also be useful for treating patients with NAFLD even in cases where NAFLD is not associated with obesity or diabetes mellitus.
Feasibility of an Autism-Focused Augmented Reality Smartglasses System for Social Communication and Behavioral Coaching (2017)

Smartglasses using augmented reality may have an important future role in helping address the therapeutic needs of children with ASD. Quantitative data gathering from such sensor-rich systems may allow for digital phenotyping and the refinement of social communication constructs of the research domain criteria. This report provides evidence for the feasibility, usability, and tolerability of one such specialized smartglasses system.
Experimental study of salt hydrates for thermochemical seasonal heat storage (2016)

Vacuum solar tube collectorsHeat load Borehole Salt hydrate
O1‐10‐06: Results From a First‐in‐Human Study with the Bace Inhibitor CNP520 (2016)

CNP520 inhibits the β-site APP cleaving enzyme 1 (BACE-1), leading to reduced formation of amyloid-β (Aβ). It is under clinical development as potentially disease-modifying treatment in asymptomatic subjects at risk of developing Alzheimer’s disease because of their ApoE genotype. This randomized, double-blind, placebo-controlled, first-in-human (FiH) study has been conducted to assess the safety/tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of single- and multiple ascending doses of CNP520. Single ascending doses were orally administered to healthy adults (n=38/14 CNP520/placebo) and elderly subjects ≥60 years (n=50/17), respectively. Multiple ascending doses were administered over two (n=45/18) and four weeks (n=10/2) to elderly only. In addition, ten healthy adults received a single dose of CNP520 under fasted and fed conditions in a cross-over fashion. Safety and tolerability were assessed based on adverse event (AE), laboratory, vital sign, ECG and other safety data. Pharmacodynamic effects were determined in elderly subjects primarily by quantification of Aβ 1-40 concentrations in cerebrospinal fluid (CSF). After single dosing, serial CSF sampling over 36h was performed. After multiple dosing, sampling was done by means of single lumbar punctures at baseline and 24h after last dose (2-week exposure) or at 2 and 4 weeks (4-week exposure). CNP520 concentrations were quantified both in plasma and CSF. CNP520 was safe and well tolerated following single and multiple doses. There was a similar incidence of AEs with CNP520 and placebo. Dose-dependent reduction of Aβ 1-40 concentrations in CSF by >90% after multiple dosing was determined. The extent of Aβ lowering was stable over four weeks of once-daily dosing. Pharmacokinetic properties included lack of relevant food effect and a terminal elimination half-life that allows once-daily dosing. The safety/tolerability, PK and PD data obtained in this FiH study support further development of CNP520 in healthy subjects at risk of Alzheimer’s disease.
Quantification of antigen-specific antibody concentrations in tracheal lavage fluid of horses with summer pasture-associated obstructive pulmonary disease (1997)

Antigen-specific IgG and IgE RAU values were not increased in SPAOPD-affected horses when these horses were manifesting clinical signs of disease.
Molecular biological and immunological techniques and applications for food chemists (2010)

CONTRIBUTORS. PREFACE. PART Ia MOLECULAR BIOLOGICAL METHODS: TECHNIQUES EXPLAINED. 1. Molecular Biology Laboratory Layout (Rainer Schubbert). 2. Polymerase Chain Reaction (Hermann Broll). 3. Quantitative Real-Time PCR (Hermann Broll). 4. Polymerase Chain Reaction Restriction Fragment Length Polymorphism Analysis (Klaus Pietsch and Hans-Ulrich Waiblinger). 5. Single-Stranded Conformation Polymorphism Analysis (Hartmut Rehbein). 6. Sequencing (Rainer Schubbert). PART Ib MOLECULAR BIOLOGICAL METHODS: APPLICATIONS. 7. Meat (Ines Laube). 8. Genetically Modified Organisms (Bert Popping). 9. Detection of Food Allergens (Carmen Diaz-Amigo and Bert Popping). 10. Offal (Neil Harris). 11. Aquatic Food (Hartmut Rehbein). PART IIa IMMUNOLOGICAL METHODS: TECHNIQUES EXPLAINED. 12. Antibody-Based Detection Methods: From Theory to Practice (Carmen Diaz-Amigo). PART IIb IMMUNOLOGICAL METHODS: APPLICATIONS. 13. Animal Specification in Speciation (Bruce W. Ritter and Laura Allred). 14. International Regulatory Environment for Food Allergen Labeling (Samuel Benrejeb Godefroy and Bert Popping). 15. Japanese Regulations and Buckwheat Allergen Detection (Hiroshi Akiyama, Shinobu Sakai, Reiko Adachi, and Reiko Teshima). 16. Egg Allergen Detection (Masahiro Shoji). 17. Soy Allergen Detection (Marcello Gatti and Cristina Ferretti). 18. Milk Allergen Detection (Sabine Baumgartner). 19. Gluten Detection (Ulrike Immer and Sigrid Haas-Lauterbach). 20. Nut Allergen Detection (Richard Fielder, Warren Higgs, and Katie Barden). 21. Fish Allergen Detection (Christiane Kruse Faeste). 22. Lupin Allergen Detection (Christiane Kruse Faeste). 23. Mustard Allergen Detection (Anne E. Ryan and Michael S. Ryan). 24. Celery Allergen Detection (Charlotta Engdahl Axelsson). INDEX.
Stochastic Resonance in Schottky Wrap Gate-controlled GaAs Nanowire Field-Effect Transistors and Their Networks (2008)

Investigation of stochastic resonance in GaAs-based nanowire field-effect transistors (FETs) controlled by Schottky wrap gate and their networks is described. When a weak pulse train is given to the gate of the FET operating in a subthreshold region, the correlation between the input-pulse and source-drain current increases by adding input noise. Enhancement of the correlation is observed in a summing network of the FETs. Measured correlation coefficient of the present system can be larger than that in a linear system in the wide range of noise. An analytical model based on the electron motion over a gate-induced potential barrier quantitatively explains the experimental behaviors.
Aberrant<i>Keap1</i>methylation in breast cancer and association with clinicopathological features (2012)

Keap1 (Kelch-like ECH-associated protein 1) is an adaptor protein that mediates the ubiquitination/degradation of genes regulating cell survival and apoptosis under oxidative stress conditions. We determined methylation status of the KEAP1 promoter in 102 primary breast cancers, 14 pre-invasive lesions, 38 paired normal breast tissues and 6 normal breast from reductive mammoplasty by quantitative methylation specific PCR (QMSP). Aberrant promoter methylation was detected in 52 out of the 102 primary breast cancer cases (51%) and 10 out of 14 pre-invasive lesions (71%). No mutations of the KEAP1 gene were identified in the 20 breast cancer cases analyzed by fluorescence based direct sequencing. Methylation was more frequent in the subgroup of patients identified as ER positive-HER2 negative tumors (66.7%) as compared with triple-negative breast cancers (35%) (p = 0.05, Chi-square test). The impact of the interactions between Er, PgR, Her2 expression and KEAP1 methylation on mortality was investigated by RECPAM multivariable statistical analysis, identifying four prognostic classes at different mortality risks. Triple-negative breast cancer patients with KEAP1 methylation had higher mortality risk than patients without triple-negative breast cancer (HR = 14.73, 95%CI: 3.65-59.37). Both univariable and multivariable COX regressions analyses showed that KEAP1 methylation was associated with a better progression free survival in patients treated with epirubicin/cyclophosfamide and docetaxel as sequential chemotherapy (HR = 0.082; 95%CI: 0.007-0.934). These results indicate that aberrant promoter methylation of the KEAP1 gene is involved in breast cancerogenesis. In addition, identifying patients with KEAP1 epigenetic abnormalities may contribute to disease progression prediction in breast cancer patients.