gebhart/patrepeval huggingface dataset:
Fetching instruction streams (2003)

Fetch performance is a very important factor because it effectively limits the overall processor performance. However there is little performance advantage in increasing front-end performance beyond what the back-end can consume. For each processor design, the target is to build the best possible fetch engine for the required performance level. A fetch engine will be better if it provides better performance, but also if it takes fewer resources, requires less chip area, or consumes less power. In this paper we propose a novel fetch architecture based on the execution of long streams of sequential instructions, taking maximum advantage of code layout optimizations. We describe our architecture in detail, and show that it requires less complexity and resources than other high performance fetch architectures like the trace cache, while providing a high fetch performance suitable for wide-issue superscalar processors. Our results show that using our fetch architecture and code layout optimizations obtains 10% higher performance than the EV8 fetch architecture, and 4% higher than the FTB architecture using state-of-the-art branch predictors, while being only 1.5% slower than the trace cache. Even in the absence of code layout optimizations, fetching instruction streams is still 10% faster than the EV8, and only 4% slower than the trace cache. Fetching instruction streams effectively exploits the special characteristics of layout optimized codes to provide a high fetch performance, close to that of a trace cache, but has a much lower cost and complexity, similar to that of a basic block architecture.
Deterministic scheduling of wafer fab operations (2003)

In this paper, we present a modification of the Shifting Bottleneck heuristic (MSB) for scheduling wafer fabrication facilities. Implementing a determinstic scheduling approach within a simulation model (ASAP) is nontrivial. The simulation model serves as the MES system emulator in addition to performing traditional simulation tasks. Implementation issues as well as results of the MSB are presented.
Intracellular signaling pathways involved in the induction of apoptosis in immature thymic T lymphocytes (1996)

We describe a novel technique for studying the signaling pathways that control thymocyte negative selection which maintains the essential interactions between thymocytes and thymic stromal cells. Bisected lobes from newborn mouse thymus are maintained in organ culture for up to 36 h, and the thymocytes analyzed by flow cytometry. Inclusion of [3H]inositol during culture allows measurements of phosphatidylinositol 4,5-biphosphate (PtdIns(4,5)P2) hydrolysis and inositol phosphate accumulation. Using this technique we have compared the thymocyte responses induced by anti-CD3, anti-Fas, Con A, and beta-adrenergic stimulation. We show that PtdIns(4,5)P2 hydrolysis precedes anti-CD3-induced thymocyte apoptosis, but not the apoptosis induced by anti-Fas. In contrast, Con A stimulates PtdIns(4,5)P2 hydrolysis, but does not induce thymocyte apoptosis. Anti-CD3, anti-Fas, and Con A all fail to change thymic cAMP levels, but beta-adrenergic stimulation causes a large increase in intracellular cAMP, and agents that elevate cAMP induce thymocyte apoptosis. Inhibition of protein synthesis (with cycloheximide or emetine) prevents the apoptosis induced by anti-CD3 and elevated cAMP, but not that induced by anti-Fas, whereas protease inhibition (with 3,4-dichloroisocoumarin or N(alpha)-tosyl-phenylalanine chloromethyl ketone) prevents the apoptosis caused by all of the effective stimuli. These results offer three important conclusions. First, activation of a variety of different signaling pathways can bring about thymocyte apoptosis. Second, ligation of the thymocyte TCR/CD3 complex provokes PtdIns(4,5)P2 hydrolysis, but signaling through this pathway alone does not necessarily lead to apoptosis. Third, by whichever signaling pathway the response is initiated, the activity of one or more protease enzymes appears to form an essential component in the final common pathway leading to apoptosis.
Racism in Our Courts: The Underfunding of Public Defenders and Its Disproportionate Impact Upon Racial Minorities (1994)

The severe underfunding of the nation's Public Defender System has jeopardized the criminal defendant's right to adequate assistance of counsel. The denial of this right has a disproportionate impact upon racial minorities because they are disproportionately represented by public defenders. The result is a violation of minorities' Sixth Amendment right to counsel and Fourteenth Amendment right to equal protection.\nThis Note examines the causes of under-funding and its effects on racial minorities. To remedy this discrimination, this Note offers several proposals, including a burden-shifting scheme, the use of the disparate impact standard to show discrimination (as opposed to the discriminatory purpose standard), and the application of strict scrutiny to statutes which fail to provide adequate funding to Public Defender offices.
Adiabatic Calorimeter for Measuring Heats of Solution at Room Temperature (1955)

An adiabatic calorimeter suitable for measurements of heats of solution in the vicinity of room temperature is described. The calorimeter vessel is hermetically sealed and suspended in a vacuum surrounded by a water jacket. The whole assembly is capable of rotation through 180° to initiate the solution process and to stir the contents. Temperatures are measured with a multijunction copper-constantan thermocouple, temperature changes of 10−4°C being detectable. The performance of the calorimeter is illustrated by some results for sodium chloride in water at 25°C. These are in reasonable agreement with the data of other workers and appear to be more self-consistent.
Novel therapeutic targets in osteoporosis (2002)

Osteoporosis is a common condition in which significant bone loss occurs resulting in an increased risk of sustaining fractures. Several licensed therapies are available to treat this condition, which suffer from several disadvantages including limited efficacy, high cost and poor long-term patient adherence as a consequence of significant side effects and inconvenient methods of administration. A wide range of therapeutic targets have been developed to provide a basis for developing newer therapies which overcome these limitations. These can be subdivided into those that are primarily directed towards inhibiting osteoclast-dependent bone resorption and those that stimulate osteoblastic bone formation. Targets can be grouped as follows: systemic factors such as steroid and peptide hormones; local factors produced in bone involved in osteoblast and osteoclastic regulation; and cellular targets such as cell membrane receptors and attachment proteins, cellular enzymes and nuclear transcription factors. To date, only a small proportion of these targets have yielded novel compounds to have entered clinical trials. However, it is anticipated that these will provide the basis for significant numbers of new therapies for osteoporosis in the foreseeable future.
Graph Analytics Through Fine-Grained Parallelism (2016)

Large graphs are getting increasingly popular and even indispensable in many applications, for example, in social media data, large networks, and knowledge bases. Efficient graph analytics thus becomes an important subject of study. To increase efficiency and scalability, in-memory computation and parallelism have been explored extensively to speed up various graph analytical workloads. In many graph analytical engines (e.g., Pregel, Neo4j, GraphLab), parallelism is achieved via one of the three concurrency control models, namely, bulk synchronization processing (BSP), asynchronous processing, and synchronous processing. Among them, synchronous processing has the potential to achieve the best performance due to fine-grained parallelism, while ensuring the correctness and the convergence of the computation, if an effective concurrency control scheme is used. This paper explores the topological properties of the underlying graph to design and implement a highly effective concurrency control scheme for efficient synchronous processing in an in-memory graph analytical engine. Our design uses a novel hybrid approach that combines 2PL (two-phase locking) with OCC (optimistic concurrency control), for high degree and low degree vertices in a graph respectively. Our results show that the proposed hybrid synchronous scheduler has significantly outperformed other synchronous schedulers in existing graph analytical engines, as well as BSP and asynchronous schedulers.
The Ribulose Monophosphate Pathway Substitutes for the Missing Pentose Phosphate Pathway in the Archaeon <i>Thermococcus kodakaraensis</i> (2006)

The ribulose monophosphate (RuMP) pathway, involving 3-hexulose-6-phosphate synthase (HPS) and 6-phospho-3-hexuloisomerase (PHI), is now recognized as a widespread prokaryotic pathway for formaldehyde fixation and detoxification. Interestingly, HPS and PHI homologs are also found in a variety of archaeal strains, and recent biochemical and genome analyses have raised the possibility that the reverse reaction of formaldehyde fixation, i.e., ribulose 5-phosphate (Ru5P) synthesis from fructose 6-phosphate, may function in the biosynthesis of Ru5P in some archaeal strains whose pentose phosphate pathways are imperfect. In this study, we have taken a genetic approach to address this possibility by using the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1. This strain possesses a single open reading frame (TK0475) encoding an HPS- and PHI-fused protein. The recombinant HPS-PHI-fused enzyme exhibited the expected HPS and PHI activities in both directions (formaldehyde fixing and Ru5P synthesizing). The TK0475 deletion mutant Delta hps-phi-7A did not exhibit any growth in minimal medium, while growth of the mutant strain could be recovered by the addition of nucleosides to the medium. This auxotrophic phenotype together with the catalytic properties of the HPS-PHI-fused enzyme reveal that HPS and PHI are essential for the biosynthesis of Ru5P, the precursor of nucleotides, showing that the RuMP pathway is the only relevant pathway for Ru5P biosynthesis substituting for the classical pentose phosphate pathway missing in this archaeon.
Fixed point models of loss networks (1989)

Abstract In this paper we review a simple class of fixed point models for loss networks. We illustrate how these models can readily deal with heterogeneous call types and with simple dynamic routing strategies, and we outline some of the recent mathematical advances in the study of such models. We describe how fixed point models lead to a natural and tractable definition of the implied cost of carrying a call, and how this concept is related to issues of routing and capacity expansion in loss networks.
Characterization of starburst dendrimers by the EPR technique. 1. Copper complexes in water solution (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCharacterization of starburst dendrimers by the EPR technique. 1. Copper complexes in water solutionM. Francesca Ottaviani, Stefan Bossmann, Nicholas J. Turro, and Donald A. TomaliaCite this: J. Am. Chem. Soc. 1994, 116, 2, 661–671Publication Date (Print):January 1, 1994Publication History Published online1 May 2002Published inissue 1 January 1994https://pubs.acs.org/doi/10.1021/ja00081a029https://doi.org/10.1021/ja00081a029research-articleACS PublicationsRequest reuse permissionsArticle Views846Altmetric-Citations225LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Cytotoxic effects of two gamma linoleic salts (lithium gammalinolenate or meglumine gammalinolenate) alone or associated with a nitrosourea (1999)

Gamma linoleic acid (GLA) salts may exert a direct antiproliferative activity on tumor cells. The cytotoxicity is linked to the generation of conjugated dienes, peroxyl radicals and superoxide radicals. Lithium gammalinolenate (LiGLA) and meglumine gammalinolenate (MeGLA) have been recently developed for enhancing the water solubility of these compounds. MeGLA or LiGLA (10(-5) to 10(-4) mol/l) and fotemustine (Fote) (2 x 10(-6) to 2 x 10(-4) mol/l) were applied, alone or in combination, for up to 9 days to two human glioblastoma cell lines A172 and U373MG. Fote was applied first followed by LiGLA and/or MeGLA. Cytotoxicity was evaluated by the MTT test, and the effects of drug combinations were analyzed by the isobolographic representation according to the Chou and Talalay method (combination indexes). For both GLA salts, cytotoxicity was manifested after 4 days of cell exposure and with very sharp dose-response curves. Comparison of IC50 values indicated that MeGLA was more active than LiGLA. There was a constant reduction in IC50 values following an increase in exposure time for A172 cells: between 4 and 9 days of cell exposure, IC50 changed from 73 to 46 microM for LiGLA and from 49 to 31 microM for MeGLA (p<0.05). With U373MG cells, there was no influence of exposure duration on IC50 values. Combination index values indicated that association between Fote and GLA salts globally resulted in slightly antagonistic effects. These results may be useful for further development of GLA salts at the clinical level.
Arithmetic Fourier Transform And Adaptive Delta Modulation: A Symbiosis For High Speed Computation (1988)

We present preliminary results on the VLSI design and implementation of a novel and promising algorithm for accurate high-speed Fourier analysis and synthesis. The Arithmetic Fourier Transform (AFT) is based on the number -theoretic method of Mobius inversion. Its computations proceed in parallel and the individual operations are very simple. Except for a small number of scalings in one stage of the computation, only multiplications by 0, +1, and -1 are required. If the input samples were not quantized and if ideal real-number operations were used internally, then the results would be exact. The accuracy of the computation is limited only by the input A/D conversion process, any constraints on the word lengths of internal accumulating registers, and the implementation of the few scaling operations. Motivated by the goal of efficient, effective, high-speed realization of the algorithm in an integrated circuit, we introduce further simplicities by the use of delta modulation to represent the input function in digital form. The result is that only binary (or preferably, ternary) sequences need to be processed in the parallel computations. And the required accumulations can be replaced by up/down counters. The dynamic range of the resulting transformation can be increased by the use of adaptive delta modulation (ADM).
Application of Recognition of Individual Genes-Fluorescence In Situ Hybridization (RING-FISH) To Detect Nitrite Reductase Genes (<i>nirK</i>) of Denitrifiers in Pure Cultures and Environmental Samples (2008)

Denitrification is an alternative type of anaerobic respiration in which nitrate is reduced to gaseous products via nitrite. The key step in this process is the reduction of nitrite to nitric oxide, which is catalyzed by two structurally different but functionally equivalent forms of nitrite reductase encoded by the nirK and nirS genes. Cultivation-independent studies based on these functional marker genes showed that in the environment there was a dominance of organisms with nirK and nirS genes presumably derived from organisms that have not been cultured yet. However, the phylogenetic affiliation of these organisms has not been resolved since the ability to denitrify is widespread in phylogenetically unrelated organisms. To unravel the phylogeny of the organisms from which the nitrite reductase (nirK) genes originated, one option is to use a special variant of whole-cell hybridization termed recognition of individual genes-fluorescence in situ hybridization (RING-FISH). In RING-FISH a multiply labeled transcript polynucleotide probe is used to detect a single gene on the bacterial chromosome during FISH. Here, RING-FISH was used with laboratory cultures and environmental samples, such as activated sludge. Furthermore, probe-based cell sorting using magnetic beads could also be carried out with mixtures of pure cultures, which led to effective depletion of the nirK-negative organism but capture of the nirK-positive organism, which was demonstrated by terminal restriction fragment length polymorphism analysis based on 16S rRNA genes. The results indicate that RING-FISH coupled with probe-based cell sorting could be used with environmental samples, which could provide a means for phylogenetic classification of nirK-type denitrifiers. Thus, the results of RING-FISH could increase our understanding of the phylogeny and function of denitrifying microorganisms in the environment.
Hierarchy of mechanisms involved in generating Na/K-ATPase polarity in MDCK epithelial cells. (1995)

We have studied mechanisms involved in generating a polarized distribution of Na/K-ATPase in the basal-lateral membrane of two clones of MDCK II cells. Both clones exhibit polarized distributions of marker proteins of the apical and basal-lateral membranes, including Na/K-ATPase, at steady state. Newly synthesized Na/K-ATPase, however, is delivered from the Golgi complex to both apical and basal-lateral membranes of one clone (II/J), and to the basal-lateral membrane of the other clone (II/G); Na/K-ATPase is selectively retained in the basal-lateral membrane resulting in the generation of complete cell surface polarity in both clones. Another basal-lateral membrane protein, E-cadherin, is sorted to the basal-lateral membrane in both MDCK clones, demonstrating that there is not a general sorting defect for basal-lateral membrane proteins in clone II/J cells. A glycosyl-phosphatidylinositol (GPI)-anchored protein (GP-2) and a glycosphingolipid (glucosylceramide, GlcCer) are preferentially transported to the apical membrane in clone II/G cells, but, in clone II/J cells, GP-2 and GlcCer are delivered equally to both apical and basal-lateral membranes, similar to Na/K-ATPase. To examine this apparent inter-relationship between sorting of GlcCer, GP-2 and Na/K-ATPase, sphingolipid synthesis was inhibited in clone II/G cells with the fungal metabolite, Fumonisin B1 (FB1). In the presence of FB1, GP-2 and Na/K-ATPase are delivered to both apical and basal-lateral membranes, similar to clone II/J cells; FB1 had no effect on sorting of E-cadherin to the basal-lateral membrane of II/G cells. Addition of exogenous ceramide, to circumvent the FB1 block, restored GP-2 and Na/K-ATPase sorting to the apical and basal-lateral membranes, respectively. These results show that the generation of complete cell surface polarity of Na/K-ATPase involves a hierarchy of sorting mechanisms in the Golgi complex and plasma membrane, and that Na/K-ATPase sorting in the Golgi complex of MDCK cells may be regulated by exclusion from an apical pathway(s). These results also provide new insights into sorting pathways for other apical and basal-lateral membrane proteins.
The profile of memory function in children with autism. (2006)

A clinical memory test was administered to 38 high-functioning children with autism and 38 individually matched normal controls, 8-16 years of age. The resulting profile of memory abilities in the children with autism was characterized by relatively poor memory for complex visual and verbal information and spatial working memory with relatively intact associative learning ability, verbal working memory, and recognition memory. A stepwise discriminant function analysis of the subtests found that the Finger Windows subtest, a measure of spatial working memory, discriminated most accurately between the autism and normal control groups. A principal components analysis indicated that the factor structure of the subtests differed substantially between the children with autism and controls, suggesting differing organizations of memory ability.
One-pot synthesis of an indole-substituted 7,8-dicarba-nido-dodecahydroundecaborate(−1) (2014)

Carbaboranes are increasingly used as pharmacophores to replace phenyl substituents in established drug molecules. In contrast to traditional organic chemistry, elaborate procedures to introduce functionality frequently fail in the case of carbaboranes and their chemistry is often hampered by degradation of the cluster. Herein, the development of a one-pot synthesis of a water-soluble N-nido-dicarbaborato indole is presented, including a proposed mechanism for the reaction sequence. These studies provide useful synthetic tools for the conjugation of two important pharmacophores, indoles and carbaboranes.
A TaqMan real-time PCR assay for the detection and quantitation of Plasmodium knowlesi (2010)

This test demonstrated excellent sensitivity and specificity, and adds P. knowlesi to the repertoire of Plasmodium targets for the clinical diagnosis of malaria by real-time PCR assays. Furthermore, quantitation of DNA copy number provides a useful advantage over other molecular assays to investigate the correlation between levels of infection and the spectrum of disease.
Optimum size of soft handover zone in power-controlled UMTS downlink systems (2002)

Soft handover has two opposing effects on UMTS downlink systems, and there is a trade-off between them. The optimum size of the soft handover zone is analysed in a power-controlled UMTS downlink system. The sensitivity of this optimum size to different system parameters, such as downlink orthogonal factor, path loss exponent, shadowing fading variable, is also analysed.
Automatic metadata-based development (2004)

Time-to-release is a challenge for organizations which develop software systems. A special kind of system, called information system (IS), can be modeled as a set of data catalogues. A data catalogue can be conceived as a functional data-depending unit composing the IS. An IS usually contains hundreds of data catalogues. Each data catalogue has its own user interface, constraints, and functionalities such as a built-in query tool, a printer tool, a filter tool, etc. This work describes a successful technical strategy developed to reduce the system coding and testing time. The technical strategy is based on metadata descriptions of data catalogues and a run-time component-based framework called data catalogue infrastructure (DCI). This work describes the most important elements of the DCI. Some measurements about the coding and testing time in real projects are presented. These measurements show a significant reduction in coding and testing time with a rate around 80%.
MOCVD Growth of Transparent Conducting Cd<sub>2</sub>SnO<sub>4</sub> Thin Films (2004)

The first preparation of transparent conducting Cd 2 SnO 4 thin films by a simple MOCVD process is described. As‐deposited films using Cd(hfa) 2 (TMEDA) (Figure), at 365 °C are found to be highly crystalline with a relatively wide range of grain size of 100–300 nm. XRD indicates a cubic spinel Cd 2 SnO 4 crystal structure and the possible presence of a small amount of CdO. The films exhibit conductivities of 2170 S/cm and a bandgap of 3.3 eV, rivaling those of commercial tin‐doped indium oxide.