gebhart/patrepeval huggingface dataset:
[Ataxia in rolling mouse Nagoya and the norepinephrine system--a psychopharmacological study]. (1982)

Rolling mouse Nagoya (RMN), an ataxia mutant mouse, is adequate to checking up the efficacy of drugs on the ataxic movement disorders. The effects of some drugs on the ataxia of RMN were investigated by open field study. The drugs administered to RMN were as follows: TRH, FLA-63, DL-threo-DOPS, phenoxybenzamine and propranolol. Ataxic gait of RMN were remarkably improved by TRH, but remained unchanged by other drugs. The pretreatments with FLA-63, DOPS and phenoxybenzamine were not influenced to the antiataxic effects of TRH, while the pretreatment with propranolol increased the antiataxic effect of TRH in RMN. These results suggest that mechanism of the improvement of ataxic gait by TRH may not be sufficiently explained through only changing norepinephrine metabolism.
Design, Synthesis, and Evaluation of Linear and Cyclic Peptide Ligands for PDZ10 of the Multi-PDZ Domain Protein MUPP1 (2007)

PDZ10 is the 10th of 13 PDZ domains found within MUPP1, a cytoplasmic scaffolding protein first identified as an endogenous binding partner of serotonin receptor type 2c (5HT2c). This association, as with those of several other interacting proteins that have subsequently been identified, is mediated through the C-terminal tail of the PDZ domain partner. Using isothermal titration calorimetry (ITC), we measured the thermodynamic binding parameters [changes in Gibbs free energy (DeltaG), enthalpy (DeltaH) and entropy (TDeltaS)] of the isolated PDZ10 domain for variable-length N-acetylated peptides from the 5HT2c serotonin receptor C-terminal sequence, as well as for octapeptides of eight other putative partner proteins of PDZ10 (5HT2a, hc-kit, hTapp1, mTapp2, TARP, NG2, claudin-1, and HPV-18 E6). In length dependence studies of the 5HT2c sequence, the maximal affinity of the peptides leveled off rapidly and further elongation did not significantly improve the dissociation constant (Kd) of 11 microM observed with the pentapeptide. Among the native partners of PDZ10, octapeptides derived from the hc-kit and 5HT2c proteins were the strongest binders, with Kd values of 5.2 and 8.5 microM, respectively. The heat capacity change (DeltaCp) for the 5HT2c octapeptide was determined to be -94 cal/mol, and a calculated estimate indicates burial of polar and apolar surface areas in equal measure upon ligand binding. Peptides with phosphoserine at either the P-1 or P-2 position experienced decreased affinity, which is in accord with the hypothesis that reversible phosphorylation is a possible mechanism for regulating PDZ domain-mediated interactions. Additionally, two conformationally constrained side chain-bridged cyclic peptide ligands were also designed, prepared, evaluated by ITC, and shown to bind PDZ10 primarily through a favorable change in entropy.
Comparative evaluation of biofilm and free cell oral vaccines against Escherichia coli in broiler chicks (2002)

A preliminaty vaccination trial in chicks was carried out to evaluate and compare the protection pattem conferred by killed biofilm and free cell oral vaccines using E. coli (078) serotype. Chicks were fed daily with killed vaccine (10° CFU) after mixing with feed from day three to day eight of the experiment and booster dose of vaccine was given from day 21 to 23 of the experiment. A maximum of 83.3 percent protection was observed in biofilm vaccinated group after challenge infection, whereas only 33.3 and 16.6 percent protection was observed in free cell vaccinated and unvaccinated group of chickens respectively.
Photoreduction-fluorescence detection of aliphatic alcohols, aldehydes, and ethers in liquid chromatography (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotoreduction-fluorescence detection of aliphatic alcohols, aldehydes, and ethers in liquid chromatographyMitchell S. Gandelman and John W. BirksCite this: Anal. Chem. 1982, 54, 12, 2131–2133Publication Date (Print):October 1, 1982Publication History Published online1 May 2002Published inissue 1 October 1982https://pubs.acs.org/doi/10.1021/ac00249a060https://doi.org/10.1021/ac00249a060research-articleACS PublicationsRequest reuse permissionsArticle Views104Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Monocyte Chemoattractant Protein-1 Expression Is Enhanced by Granulocyte-Macrophage Colony-stimulating Factor via Jak2-Stat5 Signaling and Inhibited by Atorvastatin in Human Monocytic U937 Cells (2007)

The proinflammatory cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF) is expressed in inflammatory and atherosclerotic lesions. GM-CSF is known to enhance monocytic expression of monocyte chemoattractant protein-1 (MCP-1). However, the molecular mechanism(s) by which GM-CSF up-regulates the MCP-1 expression remains to be clarified. Thus, in this study, we examined our hypothesis that GM-CSF up-regulates the MCP-1 expression via Jak2-Stat5 signaling pathway. In human monocytic cell line U937, GM-CSF increased MCP-1 expression in protein and mRNA levels. Furthermore, analysis of the GM-CSF promoter element revealed that the STAT5 (signal transducer and activator of transcription-5) transcription factor binding site, located between -152 and -144 upstream of the transcription start site, as well as Janus kinase-2-mediated Stat5 activation were necessary for the GM-CSF-induced transcriptional up-regulation of the MCP-1 gene. This GM-CSF-induced MCP-1 expression, measured as both protein and mRNA levels, was down-regulated by atorvastatin, a 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor. However, this decrease in MCP-1 expression was not at the transcriptional level of MCP-1 gene but rather at the level of the stability of MCP-1 mRNA. These results indicate that GM-CSF regulates MCP-1 expression via Janus kinase-2-Stat5 pathway and by a novel regulatory mechanism of statins to reduce inflammatory reactions by down-regulating the expression of monocytic MCP-1, which promotes atherogenesis.
Genetic variation of wood density components in young coastal Douglas-fir: implications for tree breeding (1991)

The genetic control of wood density components (earlywood density, latewood density, and latewood proportion) and their relationships with overall density in coastal Douglas-fir (Pseudotsugamenziesii (Mirb.) Franco var. menziesii) were examined to assess the usefulness of this information in breeding for wood density. The genetic relationships of wood density with intraring density variation and bole volume growth were also investigated. Increment cores were taken at breast height from 15-year-old trees of 60 open-pollinated families. Averages across each core for overall wood density, its components, and intraring density variation were determined by using X-ray densitometry. Bole volume at age 15 for the same trees was derived from tree height and diameter at breast height measurements. Although wood density components varied significantly among families and were under moderate genetic control (individual-tree heritability (h i 2 ) > 0.24), none had a higher heritability than overall density (h i 2 = 0.59). Density components had strong genetic correlations with overall density (r ≥ 0.74) but were also strongly related among themselves (0.57 ≤ r ≤ 0.92). Thus, density components have limited value in improving the efficiency of selection for overall density. Overall density was positively correlated with intraring density variation (r = 0.72) and negatively correlated with bole volume (r = −0.52). Comparison of several selection indices incorporating wood density and one or more growth traits, however, showed that it is possible to obtain substantial gains in bole volume without loss in (or even with a modest increase in) wood density. By restricting the response in wood density, the change in intraring density variation can also be limited.
Pharmacokinetics and Pharmacodynamics of Glipizide After Once‐Daily and Divided Doses (1995)

The timing of a glipizide dose in relation to a meal and simulated delayed or prolonged absorption appear to have little influence on the drug's pharmacodynamic effects.
Through-Hole Copper Electroplating Using Nitrotetrazolium Blue Chloride as a Leveler (2013)

The interaction between nitrotetrazolium blue chloride (NTBC) and copper surface was investigated using atomic force microscope (AFM) and X-ray photoelectron spectra (XPS). NTBC was employed as a leveler in the through-hole (TH) electroplating experiments. The electrochemical behaviors of NTBC were evaluated using rotating disk electrode. The results indicate that NTBC is an effective leveler used for TH electroplating. NTBC could be adsorbed on copper surface to form an adsorption layer. The adsorption behavior of NTBC on copper surface indicates that NTBC could inhibit the copper electrodeposition, which provides favorable conditions used as a leveler. In the TH electroplating experiments, a flat copper plating with uniform thickness in the TH was obtained when 3 ppm NTBC was added. The addition of NTBC could increase the cathodic polarization, which is attributed to the adsorption of NTBC on the cathode in the process of TH electroplating. The increase of potential difference at 100 and 1000 rpm with the addition of NTBC proves that NTBC is an effective additive used for TH electroplating.
CONFORMATIONAL PREFERENCES OF MONOCYCLIC PENTAOXYPHOSPHORANES VARYING IN RING SIZE (1995)

Abstract New monocyclic pentaoxyphosphoranes 1–4, 6 and the furanosyl derivative, 7, were synthesized from the reaction of tris(2,6-dimethylphenyl) phosphite (5) with a diol or a quinone. The pentacoordinated derivatives 1–4 were studied by X-ray analysis and represent the first structurally characterized monocyclic oxyphosphoranes that have six-, seven-, and eight-membered rings. All possess trigonal-bipyramidal geometries with the rings spanning apical–equatorial positions. Retention of these structures in solution is indicated by 1H, 13C, and 31P NMR. Twist-boat, rowboat, and distorted-tub conformations are found for the six- (1), seven- (2), and eight- (4) membered ring derivatives, respectively. Phosphorane 3 has a more planar phosphorinane ring, a consequence of ring unsaturation. Variable-temperature 1H and 13C NMR establish nonrigid behavior supporting a simple Berry pseudorotation in which the rings exchange apical-equatorial positions. It is concluded that six-membered rings of pentaoxyphosphoranes prefer apical–equatorial sites of a TBP. The preferred conformation of saturated six-membered rings is generally that of a boat. Phosphorane 1 crystallizes in the monoclinic space group C 2/c with a = 29.392 (8), b = 11.420 (5), c = 16.379 (2) Å, β = 92.22 (1)°, and Z = 8. Compound 2 crystallizes in the monoclinic space group P21 with a = 12.268 (2), b = 9.916 (3), c = 12.625 (2) Å, β = 91.79 (1)°, and Z = 2. The monocyclic derivative 3 crystallizes in the monoclinic space group P21/c with a = 20.114 (6), b = 9.554 (2), c = 17.178 (3) Å, β = 114.24 (2)° and Z = 4. Phosphorane 4 crystallizes in the triclinic space group P1 with a = 9.690 (2), b = 15.414 (4), c = 21.350 (5) Å, α = 93.07 (2)°, β = 90.17 (2)°, γ = 99.97 (2)°, and Z = 4. The final conventional unweighted residuals are 0.056 (1), 0.039 (2), 0.038 (3), and 0.076 (4).
Expression profiling with RNA from formalin-fixed, paraffin-embedded material (2008)

We developed a simple and robust method for isolating RNA from FFPE material. The RNA can be used for gene expression profiling. Expression measurements from several genes can be combined to robust scores representing the hormonal or the proliferation status of the tumor.
Extreme Doppler precision with octagonal fiber scramblers (2012)

The detection of Earth analogs with radial velocity requires long-term precision of 10 cm/s. One of the factors limiting precision is variation in instrumental profile from observation to observation due to changes in the illumination of the slit and spectrograph optics. Fiber optics are naturally efficient scramblers. Our research is focused on understanding the scrambling properties of fibers with different geometries. We have characterized circular and octagonal fibers in terms of focal ratio degradation, near-field and far-field distributions. We have characterized these fibers using a bench-mounted high-resolution spectrograph: the Yale Doppler Diagnostics Facility (YDDF).
A terminating reagent for the peroxidase-labelled enzyme immunoassay. (1978)

Addition of a low concentration of sodium azide completely stops colour development in a peroxidase-labelled enzyme immunoassay using 2,2'-azino-di(3-ethylbenzthiazoline sulphonic acid-6) as substrate. Whereas high concentrations of azide cause a decrease in the colour intensity, the low concentrations used here have no significant affect on the colour.
Selective Etching of Al x Ga1 − x As and In ( Al x Ga1 − x  ) As Alloys in Succinic Acid‐ Hydrogen Peroxide Solutions (1993)

Succinic acid‐hydrogen peroxide solutions were used to etch and alloys, and the etch rates were investigated with the varying alloy mole fractions. It was found that may be selectively etched over , with a selectivity better than 150. Extended surface exposure to air was found to affect the etch rates, most interestingly for . In the system, alloys with can be preferentially etched over with a selectivity of better than 20.
Visual Characteristics Of Aspirates from Feeding Tubes as a Method for Predicting Tube Location (1994)

A sample of 880 feeding tube aspirates were classified as being primarily clear or cloudy and as having one of six colors. Gastric aspirates were most frequently cloudy and green, tan or off-white, or bloody or brown. Intestinal fluids were primarily clear and yellow to bile-colored. In the absence of blood, pleural fluid was usually pale yellow and serous, and tracheobronchial secretions were usually tan or off-white mucus. However, respiratory aspirates often contained blood and therefore failed to have the expected characteristics of respiratory fluid. Staff nurses were shown photographs of a sample of 106 aspirates and asked to predict tube position. Their ability to identify 50 gastric aspirates improved significantly after reading a list of suggested characteristics of feeding tube aspirates (81.33% to 90.47%, p < .0001). Similarly, their ability to identify 50 intestinal aspirates improved from 64.07% to 71.53% after reading the list of criteria. However, nurses were often unable to identify respiratory aspirates; the accuracy of their predictions decreased after reading the list of suggested characteristics (from 56.67% to 46.11%). The appearance of aspirates is often helpful in distinguishing between gastric and intestinal placement, but is of little value in ruling out respiratory placement.
RECOMMENDED LRFD SPECIFICATIONS FOR PLASTIC PIPE AND CULVERTS (2000)

This report presents the results of an investigation of the capacity of thermoplastic culvert pipe in hoop compression and the resistance of profile wall pipe sections to failure by local buckling. The work was carried out to support development of design provisions (for plastic pipes and culverts) to be included in the American Association of State Highway and Transportation Officials load and resistance factor design (LRFD) specifications. At present, design methodology and properties for plastic pipes and culverts are governed through procedures developed for metal products. The use of plastic pipe is increasing and, therefore, so is the need for provisions to assist structural engineers to make safe, cost-effective use of these materials. The contents of the report are, therefore, of immediate interest to both highway and rail transit professionals responsible for designing, installing, inspecting, maintaining, and upgrading nonpressure drainage pipes as well as to those charged with specifying materials for such pipe.
UrineCART, a machine learning method for establishment of review rules based on UF-1000i flow cytometry and dipstick or reflectance photometer (2012)

An algorithm based on machine learning methods for review criteria can be achieved via systematic comparison of UF-1000i flow cytometry and microscopy.Using Urine CART, our microscopic review rate can be reduced to around 30 % , while decreasing significant losses in urinalysis.
Dead reckoning navigation with Constant Velocity Update (CUPT) (2012)

This paper introduces a new algorithm for dead reckoning navigation named Constant Velocity Update (CUPT), which is an extension of popular Zero Velocity Update (ZUPT). With a low-cost IMU (Inertial Measurement Unit) attached to a user's shoe, the proposed algorithm can efficiently reduce IMU errors by detecting not only the stance phases during walking, but also the cases at constant velocity, such as in an elevator or on an escalator. The concept, design and test of a CUPT prototype are detailed in this paper. Test results show that it can effectively detect constant velocity, and its horizontal positioning errors are below 0.45% of the total distance travelled, and vertical errors below 0.25%. This performance reached the highest accuracy in available literature.
Selective Serotonin Reuptake Inhibitors: Pharmacologic Profiles and Potential Therapeutic Distinctions (1994)

The four SSRIs studied appear to be more similar than they are different. Slowly, important distinctions are beginning to emerge with regard to adverse effect profiles and potential drug interactions. Given that the costs of these respective medications are comparable, such differences may ultimately serve to establish the preferential selection of individual agents in specific clinical situations.
Using Incomplete Information for Complete Weight Annotation of Road Networks (2013)

We are witnessing increasing interests in the effective use of road networks. For example, to enable effective vehicle routing, weighted-graph models of transportation networks are used, where the weight of an edge captures some cost associated with traversing the edge, e.g., greenhouse gas (GHG) emissions or travel time. It is a precondition to using a graph model for routing that all edges have weights. Weights that capture travel times and GHG emissions can be extracted from GPS trajectory data collected from the network. However, GPS trajectory data typically lack the coverage needed to assign weights to all edges. This paper formulates and addresses the problem of annotating all edges in a road network with travel cost based weights from a set of trips in the network that cover only a small fraction of the edges, each with an associated ground-truth travel cost. A general framework is proposed to solve the problem. Specifically, the problem is modeled as a regression problem and solved by minimizing a judiciously designed objective function that takes into account the topology of the road network. In particular, the use of weighted PageRank values of edges is explored for assigning appropriate weights to all edges, and the property of directional adjacency of edges is also taken into account to assign weights. Empirical studies with weights capturing travel time and GHG emissions on two road networks (Skagen, Denmark, and North Jutland, Denmark) offer insight into the design properties of the proposed techniques and offer evidence that the techniques are effective.
A 3-way SIMD Engine for Programmable Triangle Setup in Embedded 3D Graphics Hardware (2005)

A triangle setup engine (TSE) generates setup parameters for rasterization in 3D graphics hardware. Since the TSE must be flexible for various embedded systems, a programmable TSE is proposed, especially optimized for a division-free rasterizer and it shows a performance improvement up to 4.76 times, derived by a 3-way SIMD architecture with special instructions for matrix-vector multiplication. It is integrated with an optimized format converter in 0.13 /spl mu/m CMOS technology. Its gate count is 210 kgates and the power consumption is 49.1 mW at 166 MHz operation frequency.
Unscheduled expression of cyclins by anti-cancer drug exposure. (1998)

The scheduled expressions of cyclins are observed in the normal cells or the tumor cells whose phenotype is characterized by scheduled expression of cyclins, while unscheduled expression of cyclins were reported in several leukemic and solid tumor cell lines by anti-cancer drugs. We studied the effects of cytotoxic concentrations of Taxol (TXL) on cyclin D1 and B1 expression on human ovarian cancer cell lines. In KFr13 cells, the control group showed low degree of cyclin D1 and moderate degree of cyclin B1 expression in all cell cycles, while 1 microM TXL exposure resulted remarkable cyclin D1 and B1 expression in G2+M phase cells. OVCAR-3 cells showed relatively high degree of cyclin D1 expression and mild to moderate degrees of cyclin B1 expression in control group. 1 microM TXL showed no significant changes in cyclin D1 expression, while decreased expression cyclin B1 in G0+1 and S and moderate degree of expression in G2+M.
Anti–U11/U12 RNP antibodies in systemic sclerosis: A new serologic marker associated with pulmonary fibrosis (2009)

Anti-U11/U12 RNP antibodies are present in the sera of approximately 3% of patients with SSc and are a marker for lung fibrosis, which is often severe.
A Tensorial Connectivity–Tortuosity Concept to Describe the Unsaturated Hydraulic Properties of Anisotropic Soils (2003)

The anisotropy in unsaturated hydraulic conductivity is saturation dependent. Yet, there are few options for modeling this phenomenon in natural soils. A tensorial connectivity–tortuosity (TCT) concept is proposed to describe the unsaturated soil hydraulic conductivity. The TCT concept assumes that soil pore connectivity and/or tortuosity are anisotropic and can be described using a tensor. Saturation-dependent anisotropy can be easily invoked in common models of relative permeability by incorporating the connectivity tensor. Synthetic Miller-similar soils having hypothetical anisotropy are defined by allowing the saturated hydraulic conductivity to have different correlation range for different directions of flow. The TCT concept was tested using the synthetic soils with four levels of heterogeneity and four levels of anisotropy. The results show that the soil water retention curves were independent of flow direction but dependent on soil heterogeneity, while the connectivity–tortuosity coefficient is a function of both soil heterogeneity and anisotropy. The TCT model can accurately describe the unsaturated hydraulic functions of anisotropic soils and can be easily combined with commonly used relative permeability functions for use in numerical solutions of the flow equation.
Effects of flaxseed and Hypericum perforatum on hot flash, vaginal atrophy and estrogen-dependent cancers in menopausal women: a systematic review and meta-analysis. (2016)

The results of our systematic review suggest beneficial effect on vasomotor symptom with both of flaxseed and H. perforatum. Consistent conclusion regarding estrogen-dependent cancers and maturation value is limited due to small number of trials related to flaxseed. Further trials are still needed to confirm the results of our systematic review.