gebhart/patrepeval huggingface dataset:
Guided Cell Migration on Microtextured Substrates with Variable Local Density and Anisotropy (2009)

Abstract This work reports the design of and experimentation with a topographically patterned cell culture substrate of variable local density and anisotropy as a facile and efficient platform to guide the organization and migration of cells in spatially desirable patterns. Using UV‐assisted capillary force lithography, an optically transparent microstructured layer of a UV curable poly(urethane acrylate) resin is fabricated and employed as a cell‐culture substrate after coating with fibronectin. With variable local pattern density and anisotropy present in a single cell‐culture substrate, the differential polarization of cell morphology and movement in a single experiment is quantitatively characterized. It is found that cell shape and velocity are exquisitely sensitive to variation in the local anisotropy of the two‐dimensional rectangular lattice arrays, with cell elongation and speed decreasing on symmetric lattice patterns. It is also found that cells could integrate orthogonal spatial cues when determining the direction of cell orientation and movement. Furthermore, cells preferentially migrate toward the topographically denser areas from sparser ones. Consistent with these results, it is demonstrated that systematic variation of local densities of rectangular lattice arrays enable a planar assembly of cells into a specified location. It is envisioned that lithographically defined substrates of variable local density and anisotropy not only provide a new route to tailoring the cell‐material interface but could serve as a template for advanced tissue engineering.
Synthesis and Antibacterial Activity of a Novel Series of Potent DNA Gyrase Inhibitors. Pyrazole Derivatives (2004)

We have previously found that a pyrazole derivative 1 possesses antibacterial activity and inhibitory activity against DNA gyrase and topoisomerase IV. Here, we synthesized new pyrazole derivatives and found that 5-[(E)-2-(5-chloroindol-3-yl)vinyl]pyrazole 16 possesses potent antibacterial activity and selective inhibitory activity against bacterial topoisomerases. Many of the synthesized pyrazole derivatives were potent against clinically isolated quinolone- or coumarin-resistant Gram-positive strains and had minimal inhibitory concentration values against these strains equivalent to those against susceptible strains.
Lateral Integration of Partially Insulated and Bulk MOSFETs Using Partial SOI Process (2006)

We proposed and successfully demonstrated partially insulated and bulk MOSFETs with multiple V/sub th/s, I/sub on/s, and I/sub Off/s by using partial SOI process without complex process and SOI wafer. Both nMOS and pMOS applicable to the HP and LSTP transistors were simultaneously implemented on the same wafer with the same process except partial SOI process. These results must be very useful to implement IC systems requiring various specifications of V/sub TH/s, I/sub On/s, and I/sub Off/s.
Interferon in Mice: Protection against Small Doses of Virus (1967)

Microbiology Society journals contain high-quality research papers and topical review articles. We are a not-for-profit publisher and we support and invest in the microbiology community, to the benefit of everyone. This supports our principal goal to develop, expand and strengthen the networks available to our members so that they can generate new knowledge about microbes and ensure that it is shared with other communities.
Approaching the War of Ideas (2009)

War is political philosophy by other means. Politics is merely the process by which institutions—rules—distribute society’s benefits and obligations according to the philosophical ideas upon which people, leading their collective lives, have conferred legitimacy. The War of Ideas is a battle for this perception of legitimacy and accompanying popular support. Simply put, political philosophy is a hypothesis: if condition, then outcome. If a polity is organized according to a particular philosophical narrative and structure, then justice, security, and human flourishing will result. Plato, for example, advocated a rightly ordered society of philosopher kings, an auxiliary or guardian class, and producers—that is, rulers, those supporting and guided by the rulers, and the ruled. Plato supplemented this social organization with the “Noble Lie” or “Myth of the Metals,” claiming the respective social classes have gold, silver, and brass in their souls. Of course, those on the lower end of society’s benefits and privileges would believe they were not deprived as a result of some political or earthly injustice, just the harsh reality of the condition of their birth. These people are less likely to revolt.
α,β-Unsaturated Aminoketones. II. α- and β-Morpholinobenzalacetophenones<sup>*</sup> (1940)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTα,β-Unsaturated Aminoketones. II. α- and β-Morpholinobenzalacetophenones*Norman H. CromwellCite this: J. Am. Chem. Soc. 1940, 62, 11, 2897–2900Publication Date (Print):November 1, 1940Publication History Published online1 May 2002Published inissue 1 November 1940https://pubs.acs.org/doi/10.1021/ja01868a003https://doi.org/10.1021/ja01868a003research-articleACS PublicationsRequest reuse permissionsArticle Views98Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Respuesta a la hipoxia: Un mecanismo sistémico basado en el control de la expresión génica (2006)

New, critically important data have been recently generated about the response to hypoxia. This response can be schematized in three main systems or functions, ie, detectional or oxygen sensing, regulatory, which controls gene expression and effector. The principal organizer of the regulatory branch is a specific transcription factor, the hypoxia-inducible factor 1 (HIF-1). In the presence of oxygen, the a subunit of HIF-1 (HIF-1α) is modified by hydroxylases, that represent the central point of the oxygen sensing mechanism. This type of hydroxylation induces HIF-1α catabolism by the proteosome. On the contrary, in hypoxia, or in the presence of certain growth factors that increase HIF-1α synthesis, HIF-1α translocates to the nucleus, where it binds HIF-1β, and thence acts on transcription of genes carrying hypoxia responsive elements (HRE) on their promoters. These genes regulate the synthesis of an ample series of proteins, which span from respiratory enzymes and transporters to hormones regulating circulation and erythropoiesis. The role of HIF-1α is not restricted to the mere induction of adaptation to decreased oxygen: instead, it significantly participates in cell repairing mechanisms. A simple list of some of the stimulatory or inhibitory alterations of pathophysiological importance involving the HIF-1 system, would include: chronic lung disease, smoking adaptation, anemia/hemorrhage, ischemia/reperfusion, growth, vascularization and cell resistance of tumors, preeclampsia and intrauterine growth retardation, retinal hyper o hypovascularization, drug intoxications, bowel inflammatory disease and wound repair. This list illustrates by itself the importance of the mechanism herein reviewed.
Early Development of the Seed Coat of Soybean (Glycine max) (1999)

Although the development of the soybean ovule has been fairly well studied, knowledge of the sequence of events in the seed coat during the first 3 weeks after flowering is incomplete. The goal of the present study was to document, using light microscopy, the early development of the soybean seed coat with respect to changes in structure and histochemistry. At anthesis, the seed coat consists of an outer layer of cuboidal epidermal cells surrounding several layers of undifferentiated parenchyma (which together constitute the outer integument), and an inner layer of cuboidal endothelial cells (the inner integument). At 3 d post anthesis (dpa), the inner integument has expanded to include three to five layers of relatively large cells with thick, heavily-staining cell walls immediately adjacent to the endothelium. By 18 dpa, the outer integument has developed into a complex of tissues comprised of an inner layer of thick-walled parenchyma, an outer layer of thin-walled parenchyma containing vascular tissue which has grown down from the lateral vascular bundles in the hilum region, a hypodermis of hourglass cells, and palisade layer (epidermis). The thick-walled parenchyma of the inner integument has become completely stretched and compressed, leaving a single, deeply staining wall layer directly above the endothelium. At 21 dpa, the outermost cells of the endosperm have begun to compress the endothelium. At 45 dpa (physiological maturity) the seed coat retains only the palisade layer, hourglass cells, and a few layers of thin-walled parenchyma. The innermost layer of the endosperm, the aleurone layer, adheres to the inside of the seed coat. This knowledge will be invaluable in future studies of manipulation of gene expression in the seed coat to modify seed or seed coat characteristics. Copyright 1999 Annals of Botany Company
Simultaneous carbonylation and homologation of dimethyl ether and homologation of methyl acetate to ethyl acetate in the presence of ruthenium catalysts (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSimultaneous carbonylation and homologation of dimethyl ether and homologation of methyl acetate to ethyl acetate in the presence of ruthenium catalystsGiuseppe Braca, Glauco Sbrana, Giorgio Valentini, Giampaolo Andrich, and Guglielmo GregorioCite this: J. Am. Chem. Soc. 1978, 100, 19, 6238–6240Publication Date (Print):September 1, 1978Publication History Published online1 May 2002Published inissue 1 September 1978https://pubs.acs.org/doi/10.1021/ja00487a050https://doi.org/10.1021/ja00487a050research-articleACS PublicationsRequest reuse permissionsArticle Views219Altmetric-Citations58LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
YouFlow Microblog (2014)

Purpose – To present YouFlow Microblog and how its functionalities for discourse structuring and message classification allows improving learning. The paper aims to discuss these issues. Design/methodology/approach – The authors developed a survey on microblogs and its functionalities for supporting education, and then the authors developed a new microblog called YouFlow Microblog, which was used in a case study to illustrate its applicability. Findings – The results were: the categorization of messages according to the lesson plan allowed deeper discussions; the amount of messages and preference of the students for the categorization approach are directly related; the filtering of messages (categorization on the reading time) was used as a facilitator of the discussion understanding; the students prefer the search results organized by the categories and related messages; and the students were able to follow the discussions supported by the tree structure of discourse, categorization of messages according to the lesson plan and searches or filtering of messages. Research limitations/implications – Other case studies involving more students and from different knowledge areas could be performed. Other approaches for messages' visualization for reducing the amount of information could be explored, such as recommendation of messages in microblogs; and groupings of messages according to date, priority and subject. Practical implications – The developed microblog is useful and proved to be interesting for applying in the educational context. Originality/value – No other microblog allows different structuring of messages and the their classification according to the lesson plan, in addition to filtering and query functionalities.
Design methodology for pipelined heterogeneous multiprocessor system (2007)

Multiprocessor SoC systems have led to the increasing use of parallel hardware along with the associated software. These approaches have included coprocessor, homogeneous processor (e.g. SMP) and application specific architectures (i.e. DSP, ASIC). ASIPs have emerged as a viable alternative to conventional processing entities (PEs) due to its configurability and programmability. In this work, we introduce a heterogeneous multi-processor system using ASIPs as processing entities in a pipeline configuration. A streaming application is taken and manually broken into a series of algorithmic stages (each of which make up a stage in a pipeline). We formulate the problem of mapping each algorithmic stage in the system to an ASIP configuration, and propose a heuristic to efficiently search the design space for a pipeline-based multi ASIP system.
Efficacy Evaluation of Two New Teat Dip Formulations Under Experimental Challenge (1985)

Two new teat dip formulations were evaluated against Streptococcus agalactiae and Staphylococcus aureus in half-udder, experimental challenge studies. The first product contained a combination of 1.9% linear dodecyl benzene sulfonic acid - .55% iodophor. Incidence of infection was reduced 52.7 and 70.7% for Streptococcus agalactiae and Staphylococcus aureus in dipped quarters compared to undipped controls. The second formulation was a barrier-type product consisting of milk protein solubilized with lauryl sulfate, a surface active detergent and 4.8% glycerin. Rates of infection were reduced 60.3 and 67.9% for Streptococcus agalactiae and Staphylococcus aureus.
A compendium of myeloma-associated chromosomal copy number abnormalities and their prognostic value (2010)

To obtain a comprehensive genomic profile of presenting multiple myeloma cases we performed high-resolution single nucleotide polymorphism mapping array analysis in 114 samples alongside 258 samples analyzed by U133 Plus 2.0 expression array (Affymetrix). We examined DNA copy number alterations and loss of heterozygosity (LOH) to define the spectrum of minimally deleted regions in which relevant genes of interest can be found. The most frequent deletions are located at 1p (30%), 6q (33%), 8p (25%), 12p (15%), 13q (59%), 14q (39%), 16q (35%), 17p (7%), 20 (12%), and 22 (18%). In addition, copy number-neutral LOH, or uniparental disomy, was also prevalent on 1q (8%), 16q (9%), and X (20%), and was associated with regions of gain and loss. Based on fluorescence in situ hybridization and expression quartile analysis, genes of prognostic importance were found to be located at 1p (FAF1, CDKN2C), 1q (ANP32E), and 17p (TP53). In addition, we identified common homozygously deleted genes that have functions relevant to myeloma biology. Taken together, these analyses indicate that the crucial pathways in myeloma pathogenesis include the nuclear factor-κB pathway, apoptosis, cell-cycle regulation, Wnt signaling, and histone modifications. This study was registered at http://isrctn.org as ISRCTN68454111.
Recent progress in the genetics of cardiomyopathy and its role in the clinical evaluation of patients with cardiomyopathy (2011)

Recent progress in genetic cardiomyopathy points to the potential value of genetic testing in shaping the clinician's ability to diagnose and understand the pathogenetic basis of the inherited cardiomyopathies. The rapid rate at which the field is progressing emphasizes the importance of referral of such patients to multidisciplinary teams equipped to address the complex biological, social and psychological issues that accompany the genetic diagnosis of inherited cardiomyopathy.
High-temperature Raman investigation of order-disorder behavior in the<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">MgAl</mml:mi></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">O</mml:mi></mml:mrow><mml:mrow><mml:mn>4</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math>spinel (1992)

Disordering of the cations between the T and M sites complicates the analysis of the vibrational spectra of the ${\mathrm{MgAl}}_{2}$${\mathrm{O}}_{4}$ spinel, as well as many other spinels; thus, the Raman spectrum of ${\mathrm{MgAl}}_{2}$${\mathrm{O}}_{4}$ has not been satisfactorily assigned. Raman spectra of a natural spinel are reported that demonstrate the effect of rapid disordering of Mg and Al cations at high temperatures and the subsequent quenching of the disorder when the spinel was rapidly cooled to ambient temperature. These spectra are interpreted to resolve divergent interpretations of vibrational spectra of natural and synthetic ${\mathrm{MgAl}}_{2}$${\mathrm{O}}_{4}$ spinels.
Genetic Modification of <i>Bacillus subtilis</i> for Production of <scp>d</scp> - <i>chiro</i> -Inositol, an Investigational Drug Candidate for Treatment of Type 2 Diabetes and Polycystic Ovary Syndrome (2006)

D-chiro-inositol (DCI) is a drug candidate for the treatment of type 2 diabetes and polycystic ovary syndrome, since it improves the efficiency with which the body uses insulin and also promotes ovulation. Here, we report genetic modification of Bacillus subtilis for production of DCI from myo-inositol (MI). The B. subtilis iolABCDEFGHIJ operon encodes enzymes for the multiple steps of the MI catabolic pathway. In the first and second steps, MI is converted to 2-keto-MI (2KMI) by IolG and then to 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione by IolE. In this study, we identified iolI encoding inosose isomerase, which converts 2KMI to 1-keto-D-chiro-inositol (1KDCI), and found that IolG reduces 1KDCI to DCI. Inactivation of iolE in a mutant constitutively expressing the iol operon blocked the MI catabolic pathway to accumulate 2KMI, which was converted to DCI via the activity of IolI and IolG. The mutant was able to convert at least 6% of input MI in the culture medium to DCI.
Note on the gas laws (1945)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNote on the gas lawsCharles A. Stevenson Cite this: J. Chem. Educ. 1945, 22, 4, 198Publication Date (Print):April 1, 1945Publication History Received3 August 2009Published online1 April 1945Published inissue 1 April 1945https://doi.org/10.1021/ed022p198RIGHTS & PERMISSIONSArticle Views126Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (281 KB) Get e-Alerts Get e-Alerts
Hierarchical iterative linear-fitting algorithm (HILA) for phase correction in fat quantification by bipolar multi-echo sequence (2019)

The proposed HILA method provides a simple and efficient EC-phase correction method for bipolar acquisition without acquiring additional data. The appropriate choice of TEs may further reduce the effect of the residual EC-phase on accurate FF quantification with bipolar readout sequence.
CURRENT NEWS and COMMENT (1965)

The Journal of Trauma: Injury, Infection, and Critical Care: January 1965 - Volume 5 - Issue 1 - p 127-129
Procedural Constants: How Delay Aversion Shapes Reform (2015)

3, available at http://ssrn
An Optimized Anti-adherence and Anti-biofilm Assay: Case Study of Zinc Oxide Nanoparticles versus MRSA Biofilm (2020)

Biofilms form protective layers over bacteria that are associated with a majority of the hospital infections contributing to antibiotic resistance development in susceptible strains. Nowadays, there is a pressing need for developing effective anti-biofilm agents to help address the growing problem of biofilm-producing bacteria associated with antibiotic resistance. In recent years, zinc oxide nanoparticles (ZnO-NPs) has emerged as a prospective candidate for new anti-biofilm agents. The present method paper described an optimized anti-adherence and anti-biofilm assay using ZnO-NPs. The antibiotic-resistant bacteria Methicillin-resistant Staphylococcus aureus (MRSA ATCC4330) and vancomycin were used as the growth control and positive control, respectively. The result showed concentration-dependent anti-adherence and antibiofilm activity. The ZnO-NPs effectively prevented attachment of bacterial cells onto walls of wells with 51.69 ± 2.55% at the highest concentration tested (65.4 µg/mL). ZnO-NPs was also able to break-up 50% pre-formed MRSA biofilm at the lowest concentration of 13.5 µg/mL. Interestingly, ZnO-NPs at lower concentrations demonstrated significantly stronger antibiofilm activity than that of the positive control vancomycin, demonstrating that ZnO-NPs is a promising anti-biofilm agent. This method could be used as a preliminary screening of transition metal oxide nanoparticles as potential anti-adherence and anti-biofilm agents followed by other specific anti-biofilm assays.
NAVIGATION AMONG MOVABLE OBSTACLES: REAL-TIME REASONING IN COMPLEX ENVIRONMENTS (2005)

In this paper, we address the problem of Navigation Among Movable Obstacles (NAMO): a practical extension to navigation for humanoids and other dexterous mobile robots. The robot is permitted to reconfigure the environment by moving obstacles and clearing free space for a path. This paper presents a resolution complete planner for a subclass of NAMO problems. Our planner takes advantage of the navigational structure through state-space decomposition and heuristic search. The planning complexity is reduced to the difficulty of the specific navigation task, rather than the dimensionality of the multi-object domain. We demonstrate real-time results for spaces that contain large numbers of movable obstacles. We also present a practical framework for single-agent search that can be used in algorithmic reasoning about this domain.