Dietary Supplementation with Low-Dose Fish Oils Lowers Fibrinogen Levels: A Randomized, Double-Blind Controlled Study (1989)

Brief Reports1 November 1989Dietary Supplementation with Low-Dose Fish Oils Lowers Fibrinogen Levels: A Randomized, Double-Blind Controlled StudyKenneth Radack, MD, Colleen Deck, PharmD, Gertrude Huster, MHSKenneth Radack, MD, Colleen Deck, PharmD, Gertrude Huster, MHSAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-111-9-757 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIncreased concentrations of plasma fibrinogen have been positively correlated with accelerated atherosclerosis in prospective epidemiologic studies (1-3) and have been shown to be a significant independent predictor for stroke (2-4) and coronary artery disease (3). In addition, raised fibrinogen levels are one of several components contributing to a "hypercoagulable state" associated with hypertriglyceridemia (5). Because of the relation between lipid metabolism, thrombosis, and atherogenesis (6), the responsiveness of fibrinogen levels to dietary interventions may have potential clinical significance. Marine n-3 fatty acid supplementation has been shown to have beneficial antiatherogenic actions related to atherosclerosis, thrombosis, and lipid metabolism (7). Although...References1. MeadeMellowsBrozovic TSM. Haemostatic function and ischaemic heart disease: principal results of the Northwick Park Heart Study. Lancet. 1986;2:533-7. CrossrefMedlineGoogle Scholar2. WilhelmsenSvardsuddKorsan-BengtsenLarssonWelinTibblin LKKBLG. Fibrinogen as a risk factor for stroke and myocardial infarction. N Engl J Med. 1984;311:501-5. CrossrefMedlineGoogle Scholar3. KannelWolfCastelliD'Agostino WPWR. Fibrinogen and risk of cardiovascular disease. The Framingham Study. JAMA. 1987;258:1183-6. CrossrefMedlineGoogle Scholar4. WelinSvardsuddWilhelmsenLarssonTibblin LKLBG. Analysis of risk factors for stroke in a cohort of men born in 1913. N Engl J Med. 1987;317:521-6. CrossrefMedlineGoogle Scholar5. SimpsonMannMeadeChakrabartiStirlingWoolf HJTRYL. Hypertriglyceridaemia and hypercoagulability. Lancet. 1983;1:786-90. CrossrefMedlineGoogle Scholar6. Smith E. Fibrinogen, fibrin and fibrin degradation products in relation to atherosclerosis. Clin Haemotol. 1986;15:355-70. CrossrefMedlineGoogle Scholar7. LeafWeber AP. Cardiovascular effects of n-3 fatty acids. N Engl J Med. 1988;318:549-57. CrossrefMedlineGoogle Scholar8. HostmarkBjerkedalKierulfFlatenUlshagen ATPHK. Fish oil and plasma fibrinogen. BMJ. 1988;297:180-1. CrossrefMedlineGoogle Scholar9. RogersJamesButlandEtheringtonO'BrienJones SKBMJJ. Effects of a fish oil supplement on serum lipids, blood pressure, bleeding time, hemostatic and Theological variables. A double blind randomised controlled trial on healthy volunteers. Atherosclerosis. 1987;63:137-43. CrossrefMedlineGoogle Scholar10. Vermylende VrekerVerstraete CRM. A rapid enzymatic method for assay of fibrinogen fibrin polymerization time (FPT test). Clin Chim Acta. 1963;8:418-24. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From the University Hospital, University of Cincinnati, and the University of Cincinnati College of Medicine, Cincinnati, Ohio. For current author addresses, see end of text. 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Implications for new antithrombotic strategiesOmega-3 Fatty Acids and the Vascular SystemFish Oil Supplementation Inhibits Platelet Aggregation and ATP Release Induced by Platelet-activating Factor and Other AgonistsNo changes in PAI-1 levels after four-month n-3 PUFA ethyl ester supplementation in healthy subjectsn-3 Fatty Acids and Renal DiseasesFibrinogen in Human AtherosclerosisThe effects of n-3 fatty acids on plasma lipids and lipoproteins and other cardiovascular risk factors in patients with hyperlipidemiaAssociations of fish intake and dietary n-3 polyunsaturated fatty acids with a hypocoagulable profile. The Atherosclerosis Risk in Communities (ARIC) Study.Pharmacological control of hypertriglyceridemiaPlasma fibrinogen and its correlates in Japanese and US population samples.Drugs controlling triglyceride metabolismFibrin and Its Derivatives in the Normal and Diseased Vessel WallDrugs affecting plasma fibrinogen levelsDietary lipids and coronary heart desease: Old evidence, new persspectiveFish oils in the prevention of atherosclerosisFish and fish oil intake: Effect on haematological variables related to cardiovascular diseaseEffect of Dietary Marine Lipids on (Anti-)Thrombotic MechanismsCardiovascular risk factor clustering and ratio of total cholesterol to high-density lipoprotein cholesterol in angiographically documented coronary artery diseaseDiet and Cardiovascular DiseaseThe comparative effects of n-3 and n-6 polyunsaturated fatty acids on plasma fibrinogen levels: a controlled clinical trial in hypertriglyceridemic subjects.Another piece of the fish oil puzzle. 1 November 1989Volume 111, Issue 9Page: 757-758KeywordsAtherosclerosisFibrinogenHospital medicineLipid metabolismLipidsOilsProspective studiesStable coronary artery diseaseStrokeThrombosis Issue Published: 1 November 1989 PDF DownloadLoading ...