gebhart/patrepeval huggingface dataset:
Coumarin-Based Thiol Chemosensor: Synthesis, Turn-On Mechanism, and Its Biological Application (2011)

A new chemodosimetric probe (1) is reported that selectively detects thiols over other relevant biological species by the turning on of its fluorescence through a Michael type reaction. The fluorogenic process upon its reaction was revealed to be mediated by intramolecular charge transfer, as confirmed by time-dependent density functional theory calculations. The application of probe 1 to cells is also examined by confocal microscopy, and its cysteine preference was observed by an ex vivo LC-MS analysis of the cellular metabolite.
Patterns of methylation profiles as diagnostic markers for multiple hepatocellular carcinomas (2004)

Methylation profiling seems to be useful in differentiating the clonal origins of multiple cancers, as the information yielded by this method is essentially objective.
Constant-frequency zero-voltage-switched multi-resonant converters: analysis, design, and experimental results (2002)

The multi-resonant-switch concept is modified to provide constant-frequency operation. Complete DC analysis and designs of the constant frequency forward and half-bridge multi-resonant converters are presented. Different implementations for the half-bridge topology are discussed. The performances of a 50 W forward converter and a 100 W, offline, half-bridge converter are also presented. A significant constant improvement of the performance of the constant-frequency zero-voltage-switched multi-resonant converter is expected from the development of MOSFETs with very low on-resistance (synchronous rectifiers).< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The role of the carrier protein and disulfide formation in the folding of beta-lactamase fusion proteins in the endoplasmic reticulum of yeast. (1994)

We have studied the relationship between folding and secretion competence of hsp150-beta lactamase fusion proteins in Saccharomyces cerevisiae. hsp150 is a secretory protein of yeast, and beta-lactamase was chosen, since its folding can be monitored by assaying its enzymatic activity. The hsp150 pre-pro-protein consists of a signal peptide, subunit I, a repetitive region, and a unique C terminus. Fusion of beta-lactamase to the C terminus of hsp150 produced Cla-bla protein, which was secretion-competent but inactive. The Pst-bla protein, where beta-lactamase was fused to subunit I, was also inactive and mostly secreted, but part of it remained in the pre-Golgi compartment. When beta-lactamase was fused to the C-terminus of the repetitive region, the fusion protein (Kpn-bla) was translocated to the endoplasmic reticulum, acquired disulfide bonds, and adopted an enzymatically active conformation. Kpn-bla was secreted to the medium without decrease of specific activity or retention in the cell. Folding of Kpn-bla to an active and transport-competent form required co-translational disulfide formation, since treatment of cells with dithiothreitol resulted in endoplasmic reticulum-retained inactive Kpn-bla. When dithiothreitol was removed, Kpn-bla resumed transport competence but remained inactive. Reduction of prefolded Kpn-bla did not inhibit enzymatic activity or transport. The repetitive hsp150 carrier may have use in heterologous protein production by conferring secretion competence to foreign proteins in yeast.
A Sensitive and Facile Assay for the Measurement of Activated Protein C Activity Levels in Vivo (1993)

Activated protein C (APC) is a serine protease which plays an important role as a naturally occurring antithrombotic enzyme. APC, which is formed by thrombin-catalyzed limited proteolysis of the zymogen protein C, functions as an anticoagulant by proteolytic inactivation of the coagulation cofactors VIIIa and Va: APC is inhibited by several members of the serpin family as well a by alpha 2-macroglobulin. APC is being developed as a therapeutic for the prevention and treatment of thrombosis. We have developed an assay to quantify circulating levels of enzymatically active APC during its administration to patients, in healthy individuals, and in various disease states. This assay utilizes an EDTA-dependent anti-protein C monoclonal antibody (Mab) 7D7B10 to capture both APC and protein C from plasma, prepared from blood collected in an anticoagulant supplemented with the reversible inhibitor p-aminobenzamidine. Mab 7D7B10-derivatized agarose beads are added to the wells of a 96-well filtration plate, equilibrated with Tris-buffered saline, and incubated for 10 min with 200 microliters of plasma. After washing, APC and protein C are eluted from the immunosorbent beads with a calcium-containing buffer into the wells of a 96-well microtiter plate containing antithrombin III (ATIII) and heparin. The amidolytic activity of APC is then measured on a kinetic plate reader following the addition of L-pyroglutamyl-L-prolyl-L-arginine-p-nitroanilide (S-2366) substrate. The rate of substrate hydrolysis was proportional to APC concentration over a 200-fold concentration range (5.0 to 1,000 ng/ml) when measured continuously over a 15 to 30 min time period.(ABSTRACT TRUNCATED AT 250 WORDS)
Concanavalin A-captured Glycoproteins in Healthy Human Urine (2005)

Both the urinary proteome and its glycoproteome can reflect human health status, and more directly, functions of kidney and urinary tracts. Because the high abundance protein albumin is not N-glycosylated, the urine N-glycoprotein enrichment procedure could deplete it, and urine proteome could thus provide a more detailed protein profile in addition to glycosylation information especially when albuminuria occurs in some kidney diseases. In terms of describing the details of urinary proteins, the urine glycoproteome is even a better choice than the proteome itself. Pooled urine samples from healthy volunteers were collected and acetone-precipitated for proteins. N-Linked glycoproteins enriched with concanavalin A affinity purification were separated and analyzed by SDS-PAGE-reverse phase LC/MS/MS or two-dimensional LC/MS/MS. A total of 225 urinary proteins were identified based on two-hit criteria with reliability over 97% for each peptide. Among these proteins, 94 were identified in previous urine proteome works, 150 were annotated as glycoproteins in Swiss-Prot, and 43 were predicted as glycoproteins by NetNGlyc 1.0. A number of known biomarkers and disease-related glycoproteins were identified. Because changes in protein quantity or the glycosylation status can lead to changes in the concanavalin A-captured glycoprotein profile, specific urine glycoproteome patterns might be observed for specific pathological conditions as multiplex urinary biomarkers. Knowledge of the urine glycoproteome is important in understanding kidney and body function.
Long‐Lifetime Polymer Light‐Emitting Electrochemical Cells Fabricated with Crosslinked Hole‐Transport Layers (2009)

By inserting a crosslinkable hole-transport layer as the buffer layer between the single-phase polymer active layer and the anode of this new type of polymer light-emitting electrochemical cells (PLECs), the interface properties are improved and the PLECs can be operated with enhanced stability.
SpringView: Cooperation of Radviz and Parallel Coordinates for View Optimization and Clutter Reduction (2006)

In this paper we integrate radviz and parallel coordinates, two methods able to handle multidimensional datasets, exploiting their contrasting characteristics. From on side radviz offers good direct data manipulation (i.e., brushing) techniques and low cluttering but it fails in providing visualization of quantitative information; conversely, parallel coordinates clearly shows the values of data attributes and their ranges but suffers from high cluttering also on small datasets and presents tedious manipulation techniques. We developed a prototype, called SpringView, that allows for simultaneously viewing both radviz and parallel coordinates and implements several useful techniques to manipulate the data, both interactively and, more interestingly, automatically. We challenged our approach against two well know multidimensional datasets, proving its effectiveness.
Organic fluorine chemistry (1968)

ADVERTISEMENT RETURN TO ISSUEPREVReportNEXTOrganic fluorine chemistryClay M. Sharts Cite this: J. Chem. Educ. 1968, 45, 3, 185Publication Date (Print):March 1, 1968Publication History Received3 August 2009Published online1 March 1968Published inissue 1 March 1968https://doi.org/10.1021/ed045p185RIGHTS & PERMISSIONSArticle Views695Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (6 MB) Get e-Alerts Get e-Alerts
Efficacy and Safety of Lovastatin in Adolescent Males With Heterozygous Familial Hypercholesterolemia (1999)

This study in adolescent boys with HeFH confirmed the LDL-C-reducing effectiveness of lovastatin. Comprehensive clinical and biochemical data on growth, hormonal, and nutritional status indicated no significant differences between lovastatin and placebo over 48 weeks, although further study is required.
A headsup on GUI styleguides (1993)

This article reports on a Special Interest Group meeting at CHI'92 to discuss issues associated with the development, deployment and use of design guidelines for Graphical User Interfaces (GUIs). We discovered that styleguide practitioners (those who are responsible for developing commercial or inhouse guidelines) are desperately in need of moral support, advice on how to construct styleguides, and access to a sound, scientific base of HCI information that can be used to help make design decisions in the real world. The immediate challenges facing the Human Factors community are the need for solid and timely research to support guidelines, better transfer of research results to the real world, and the evolution of styleguide development into a systematic methodology that produces good guidelines and, therefore, good user interfaces.
A new concept in the reliability evaluation of vehicular radio (1960)

This paper describes automatic equipment developed to conduct temperature tests of two-way vehicular radio. The automatic test unit reported below controls the temperature chamber, maintains input voltages at proper EIA specified levels, turns test specimens on and off, measures the operational performance parameters of transmitters and receivers at each of the selected temperature conditions and prints the data. Four units can be tested at a time and these may be any combination of standard frequency bands, carrier or continuous tone coded squelch and wide band or split channel.
Imaging of Weak-Source Distributions in LSO-Based Small-Animal PET Scanners (2007)

It is possible to visualize sources of <1 kBq in LSO-based animal PET systems by raising the LLD to 400 keV to exclude the majority of the counts due to the intrinsic activity present in the LSO.
Application of method for getting direction image based on gradient in fingerprint preprocessing (2011)

The fingerprint image preprocessing is the premise and basis for fingerprint identification. It will directly influence the final outcome of fingerprint identification. In order to maintain and restore fingerprint ridge structures, and improve the noise immunity of fingerprint image preprocessing algorithm. In the paper, a method for getting direction image based on gradient is given. Using direction information of fingerprint image, we execute a sequence of operations, such as: image enhancement, binarization, thinning, and a more accurate linear graph is obtained. This method which is proposed in process of fingerprint preprocessing can effectively improve the quality of fingerprint ridge and can obviously restrain all kinds of noises. The experiment result shows that the method achieves the desired result.
Collateral Ventilation in Man (1978)

To determine whether collateral ventilation (defined as the ventilation of alveolar structures through passages or channels that bypass the normal airways) changes with age or emphysema, we compared the mechanics of collateral ventilation in seven young normal subjects, three old normal subjects and five patients with emphysema. In supine normal subjects at the end of a quiet expiration, resistance to airflow was greater through collateral channels than through bronchi and bronchioles. In emphysema, airways resistance could exceed collateral resistance, causing air to flow preferentially through collateral pathways. We conclude that high collateral resistance minimizes collateral airflow in supine normal subjects. When peripheral airways become obstructed or obliterated in emphysema, collateral channels may provide for more even distribution of ventilation. (N Engl J Med 298:10–15, 1978)
Management of bacterial prostatitis: what’s new? (2008)

Prostatitis is a common healthcare issue affecting 10-14% of men of all ages and ethnicities. Acute bacterial prostatitis is associated with severe, mainly Gram-negative infection; treatment consists of broad-spectrum antibiotic therapy for 2-4 weeks, which can be tailored according to pathogen identification and susceptibility tests. Chronic bacterial prostatitis is more difficult to diagnose as the symptoms are shared by chronic pelvic pain syndrome; only 10% of patients with chronic prostatitis symptoms actually have bacterial infection. The pathogens associated with this condition are essentially common uropathogens, although there is debate around the role of Gram-positive bacteria. Definitive diagnosis is obtained with the Meares-Stamey four-glass test, or the two-glass test in routine practice, which differentiates between chronic bacterial prostatitis and chronic pelvic pain syndrome. The fluoroquinolones are the first choice of therapy for chronic bacterial prostatitis, in particular levofloxacin which is as effective as ciprofloxacin but shows a better prostatic penetration and is given once daily.
Augmented Reality in Warehouse Operations: Opportunities and Barriers (2017)

In today’s business environment, the efficiency of warehouses can be critical for the efficiency of the overall supply chains they belong to. As a result, new technologies are being tested and adopted in industry to improve the performance of warehouse operations. An example technology that has recently gained interest by both academia and industry is augmented reality. In this paper, we investigate the opportunities arising from the usage of augmented reality in warehouses as well as the barriers for its industrial adoption. This is done via a series of practitioners interviews and via an experiment designed using Google Glass. Our results indicate that even though the technology is not mature enough at the moment, the potential benefits it can offer make it promising for the near future.
Data Mining Network Traffic (2006)

In this paper we present a novel approach to network traffic analysis. In particular, we show how to determine which statistical traffic descriptors are most pertinent in predicting important network performance metrics such as packet loss rate, based on empirical data. In addition, we reveal the relationship between the pertinent traffic descriptors and packet loss rate via fuzzy if-then rules. The principal finding of this paper is that descriptors that quantify intermittency such as the generalized fractal dimensions D1, D2 and D3 or parameter that quantify variability such as the Holder exponent h1 are better indicators of packet loss rate than the more commonly used Hurst parameter H and tail exponent alpha of a long-range dependent and heavy-tail random variable, respectively. A simple fuzzy inference system that incorporates rules generated from these traffic descriptors was able to predict the packet loss rate reasonably well, verifying the above claim
Fluoreszierende Stoffe aus <i>Drosophila melanogaster</i>. 7. Mitteilung. Synthese und Eigenschaften des L‐<i>erythro</i>‐2‐Amino‐6‐hydroxy‐8‐dihydroxypropyl‐pteridins und des D‐<i>threo</i>‐2‐Amino‐6‐hydroxy‐8‐dihydroxypropyl‐pteridins (1958)

Abstract Die Synthesen von L ‐ erythro ‐2‐Amino‐5‐hydroxy‐8‐dihydroxypropyl‐pte‐ridin und D ‐ threo ‐2‐Amino‐6‐hydroxy‐8‐dihydroxypropyl‐pteridin werden be‐schrieben und die Eigenschaften dieser beiden Verbindungen mit denjenigen des Drosophila‐Pteridins HB, verglichen.
Transition Metal Dithiolate Complexes. I. π-Cyclopentadienyl Maleonitrile Dithiolate Compounds (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTransition Metal Dithiolate Complexes. I. π-Cyclopentadienyl Maleonitrile Dithiolate CompoundsJ. Locke and J. A. McClevertyCite this: Inorg. Chem. 1966, 5, 7, 1157–1161Publication Date (Print):July 1, 1966Publication History Published online1 May 2002Published inissue 1 July 1966https://pubs.acs.org/doi/10.1021/ic50041a018https://doi.org/10.1021/ic50041a018research-articleACS PublicationsRequest reuse permissionsArticle Views332Altmetric-Citations91LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Synthetic and structural studies on carboxy, carbomethoxy, and trimethylsilyl derivatives of (.eta.5-cyclopentadienyl)(.eta.7-cycloheptatrienyl)titanium (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleSynthetic and structural studies on carboxy, carbomethoxy, and trimethylsilyl derivatives of (.eta.5-cyclopentadienyl)(.eta.7-cycloheptatrienyl)titaniumMarvin D. Rausch, Masao Ogasa, Robin D. Rogers, and Andrew N. RollinsCite this: Organometallics 1991, 10, 6, 2084–2086Publication Date (Print):June 1, 1991Publication History Published online1 May 2002Published inissue 1 June 1991https://pubs.acs.org/doi/10.1021/om00052a069https://doi.org/10.1021/om00052a069research-articleACS PublicationsRequest reuse permissionsArticle Views104Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Postoperative gait deterioration after bilateral subthalamic nucleus stimulation in Parkinson's disease (2008)

Deep brain stimulation of the subthalamic nuclei (STN) is a good therapeutic option to reduce dyskinesias and improve appendicular motor signs in well-selected patients with advanced Parkinson's disease (PD). Concerns about long-term adverse effects play an increasingly role in the decision whether or not to refer patients for this treatment. Worsening of gait as a consequence of STN stimulation for PD has been described, but may be under-recognized in clinical practice. The aim of this study was to evaluate the effects of STN stimulation on gait relative to global outcome in a group of consecutively operated patients. For this purpose, we used a standardized patient questionnaire that asked about global outcome and specific effects on gait, as experienced both 6 months postoperatively and currently (at the time of completing the questionnaire; mean: 2.7 +/- 1.1 years). A delayed worsening of gait after bilateral STN stimulation was experienced by a considerable proportion of patients (42% of subjects, for gait in the OFF phase), and this was apparently relatively "selective" because their global outcome scores continued to be improved. These findings highlight the presence of a hitherto poorly recognized long-term complication of bilateral STN stimulation. Further systematic studies are required to pinpoint the clinical and surgical determinants of this late gait deterioration.
Acoustic Emission in the Frequency Domain (1975)

A means for quickly and easily determining the broadband frequency content of acoustic bursts as short as 20 μs in duration has been developed using a video tape recorder and a standard spectrum analyzer. It is shown by examples from several tests on laboratory specimens and on large structures that the frequency content of an acoustic burst is related to the mechanism which produced it and is not affected substantially by the specimen size or by mode conversion due to multiple reflections in the structure. The frequency content of the burst can be changed in two ways, however: by the frequency-dependent attenuation of the propagation medium and in the cases where the medium is dispersive. Results of measurements on the effect of these factors in a variety of structures are given. Although acoustic emissions from many materials tend to be “white noise,” several examples of acoustic emissions and extraneous background noise bursts having distinctive frequency spectra are given which suggest possibilities for discriminating true acoustic emission signals from background noise on the basis of frequency content alone.