gebhart/patrepeval huggingface dataset:
Simultaneous optimisation of dynamic power, area and delay in behavioural synthesis (2000)

Concern over power dissipation, coupled with the continuing rise in system size and complexity, means that there is a growing need for high-level design tools capable of doubt automatically optimising systems to take into account power dissipation, in addition to the more conventional metrics of area, delay and testability. Current methods for reducing power consumption tend to be ad-hoc: for example, slowing down, or turning off idle parts of the system, or a controlled reduction in power supply. The behavioural synthesis system described here features an integrated incremental power estimation capability, which makes use of activity profiles, generated automatically through simulation of a design on any standard VHDL simulator; accurate circuit-level cell models (generated, again automatically, via SPICE simulation); and a comprehensive system power model. This data, along with similar estimators for area and delay, guides the optimisation of a design towards independent user-specified objectives for final area, delay, clock speed, and energy consumption. In addition, a range of power reducing features are included, encompassing: supply voltage scaling, clock gating, input latching, input gating, low-power cells, and pipelined and multicycle units. These are automatically exploited during optimisation as part of the area/delay/power dissipation trade-off process. The resulting system is capable of reducing the estimated energy consumption of several benchmark designs by factors of between 3.5 and 7.0 times. Furthermore, the design exploration capability enables a range of alternative structural implementations to be generated from a single behavioural description, with differing area/delay/power trade-offs.
Diesel Fuel Injection System Simulation and Experimental Correlation (1971)

<div class="htmlview paragraph">A theoretical digital simulation of a conventional diesel fuel injection system has been developed. The influence of such factors as wave propagation phenomena, pipe friction, and cavitation are included. The computer results are compared with transient pressures as measured on an actual fuel injection system operated on a test bench. The comparisons show the accuracy and validity of this simulation scheme. Special attention is given to some of the important factors that affect the accuracy of the simulation model. These include the effect of pressure on the fuel bulk modulus and wave speed, the pipe line residual pressure, and the coefficient of discharge of important orifices.</div>
The role of heparin and allied compounds in the treatment of sepsis (2007)

The crosstalk between coagulation and inflammation and the propensity for microthromboembolic disease during sepsis calls for anticoagulant measures to prevent tissue hypoxygenation and to attenuate organ damage and dysfunction. Only one anticoagulant, recombinant human activated protein C (aPC, drotrecogin-alpha) has a proven survival benefit when used as an adjunctive therapy for human sepsis, partly because of its anti-inflammatory effect. However, heparin (-like compounds) may exert similar beneficial anti-inflammatory actions as aPC, in spite of the relatively narrow therapeutic window for anticoagulation. This narrative review is based on a Medline search of relevant basic and clinical studies published in English and discusses the potential role of heparin in modulating inflammatory responses in the treatment of animal models and human sepsis and its harmful sequelae. In any case, the results of a meta-analysis based on animal data suggest a potentially life-saving effect of heparin (-like compounds) in the treatment of sepsis. Therefore, a prospective randomized clinical trial is called upon to study effects in human sepsis.
User interface requirements for face to face groupware (1990)

This paper discusses the user interface of the Capture Lab, a computer-supported meeting room that has been in operation since late 1987. One goal of the Capture Lab design is to support meetings of business people (who are often novice computer users) without requiring an additional person to serve as a computer technician or facilitator. This paper discusses the user interface features a system should have to support face to face meetings. It describes the Capture Lab and how it is used, and presents our approach to satisfying those interface requirements. Finally, we discuss a few of our observations about the Capture Lab's user interface, and how a computer-supported meeting environment affects meetings.
Cellular Uptake, Cytotoxicity, and Innate Immune Response of Silica−Titania Hollow Nanoparticles Based on Size and Surface Functionality (2010)

Silica-titania hollow nanoparticles (HNPs) with uniform diameters of 25, 50, 75, 100, and 125 nm were fabricated by dissolution and redeposition method in order to evaluate size dependent cellular response. Surface-modified HNPs with cationic, anionic, and neutral functional group were prepared by silane treatment. We systematically investigated cellular internalization, toxicity, and innate immune response of HNPs in human breast cancer (SK-BR-3) and mouse alveolar macrophage (J774A.1) cells. Size- and surface functionality-dependent cellular uptake of HNPs was investigated by fluorescence labeling (fluorescein isothiocyanate), inductively coupled plasma-emission spectroscopy, and ultrastructural resolution using transmission electron microscopy. Viability, reactive oxygen species, and apoptosis/necrosis of HNP-treated J774A.1 revealed the size-dependent phenomenon. Innate immune response of HNP-treated macrophages was measured by three cytokines such as interleukin-1, interleukin-6, and tumor necrosis factor α. Among the HNPs of different sizes, 50-nm HNPs demonstrated the highest toxic influence on macrophages. Among the HNPs with surface functionalities, cationic HNPs demonstrated the most toxic effect on J774A.1 and the highest uptake efficiency. The toxicity results of HNP-treated macrophages were consistent with the cellular internalization efficiency. These findings provide size- and surface functionality-dependent nanotoxicity and uptake of HNPs, and lead to HNPs for bioapplications such as drug delivery and imaging probe.
Encoding Long Options in the Dynamic Host Configuration Protocol (DHCPv4) (2002)

This document specifies the processing rules for Dynamic Host Configuration Protocol (DHCPv4) options that appear multiple times in the same message. Multiple instances of the same option are generated when an option exceeds 255 octets in size (the maximum size of a single option) or when an option needs to be split apart in order to take advantage of DHCP option overloading. When multiple instances of the same option appear in the options, file and/or sname fields in a DHCP packet, the contents of these options are concatenated together to form a single option prior to processing.
Incidence of Perthes' disease in Uppsala, Sweden (1992)

The annual incidence of Perthes' disease in Uppsala County, Sweden, was computed for the years 1978-1989 and further analyzed as regards age and sex distribution. The annual incidence was 8.5 per 100,000 in children 0-14 years of age.
Microtechnique for Most-Probable-Number Analysis (1977)

A microtechnique based on the most-probable-number (MPN) method has been developed for the enumeration of the ammonium-oxidizing population in soil samples. An MPN table for a research design ([8 by 12] i.e., 12 dilutions, 8 replicates per dilution) is presented. A correlation of 0.68 was found between MPNs determined by the microtechnique and the standard tube technique. Higher MPNs were obtained with the microtechnique with increased accuracy in endpoint determinations being a possible cause. Considerable savings of time, space, equipment, and reagents are observed using this method. The microtechnique described may be adapted to other microbial populations using various types of media and endpoint determinations.
Duplication of the lantibiotic structural gene in M-type 49 group A streptococcus strains producing streptococcin A-M49 (1994)

Streptococcin A-M49 is produced by certain strains of M-type 49 group A streptococci. The structural gene for streptococcin A-M49 was cloned after hybridization with a probe containing the scnA lantibiotic structural gene. Sequence analysis revealed a duplication of the scnA gene; each gene (scnA' and scnA") encoded a 51-amino-acid prepeptide.
OFDM for cognitive radio: merits and challenges (2009)

Cognitive radio is a novel concept that enables wireless systems to sense the environment, adapt, and learn from previous experience to improve the quality of the communication. However, CR requires a flexible and adaptive physical layer in order to perform the required tasks efficiently. In this article, CR systems and their requirement of a physical layer are discussed, and the orthogonal frequency division multiplexing technique is investigated as a candidate transmission technology for CR. The challenges that arise from employing OFDM in CR systems are identified. The cognitive properties of some OFDM-based wireless standards also are discussed to indicate the trend toward a more cognitive radio.
Lipid Peroxidation in Hepatic Fibrosis (2012)

Damage of any etiology, such as infection with hepatitis C virus (HCV) or hepatitis B virus (HBV), heavy alcohol intake, and iron overload, to hepatocytes can produce oxygen-derived free radicals and other ROS derived from lipid peroxidative processes. Persistent production of ROS constitutes a general feature of a sustained inflammatory response and liver injury, once antioxidant mechanisms have been depleted. The major source of ROS production in hepatocytes is NADH and NADPH oxidases localized in mitochondria (Figure 1). NADH and NADPH oxidases leak ROS as part of its operation. Kupffer cells (hepatic resident macrophages), infiltrating inflammatory cells such as macrophages and neutrophils, and HSCs also produce ROS in the injured liver.
SYNTHESIS OF SAFETY RESEARCH RELATED TO SPEED AND SPEED MANAGEMENT (1998)

This report presents a synthesis of research findings on the safety effects of speed, speed limits, enforcement, and engineering measures to manage speed. The report is the update of research on speed and speed control that was originally published in 1963 and updated in 1970 by the Highway Users Federation for Safety and Mobility as a chapter in Traffic Control and Roadway Elements--Their Relationship to Highway Safety. The synthesis was updated again in 1982 by the Federal Highway Administration. A great deal of speed related research has been carried out since that time. This synthesis highlights the results of significant safety research related to speed completed since the last update in 1982. Some of the earlier benchmark studies are summarized where appropriate. The report is a product of the FHWA-NHTSA Speed Management Team.
Model-driven development of context-aware Web applications (2007)

Context-aware, multi-channel Web applications are more and more gaining consensus among both content providers and consumers, but very few proposals exist for their conceptual modeling. This article illustrates a conceptual framework that provides modeling facilities for context-aware, multichannel Web applications; it also shows how high-level modeling constructs can drive the application development process through automatic code generation. Our work stresses the importance of user-independent, context-triggered adaptation actions, in which the context plays the role of a “first class” actor , operating independently of users on the same hypertext the users navigate. Modeling concepts are based on WebML (Web Modeling Language), an already established conceptual model for data-intensive Web applications, which is also accompanied by a development method and a CASE tool. However, given their general validity, the concepts of this article shape up a complete framework that can be adopted independently of the chosen model, method, and tool.
Isolation and Characterization of the Saccharomyces cerevisiae EKI1 Gene Encoding Ethanolamine Kinase (1999)

Ethanolamine kinase (ATP:ethanolamine O-phosphotransferase, EC 2.7.1. 82) catalyzes the committed step of phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway. The gene encoding ethanolamine kinase (EKI1) was identified from the Saccharomyces Genome Data Base (locus YDR147W) based on its homology to the Saccharomyces cerevisiae CKI1-encoded choline kinase, which also exhibits ethanolamine kinase activity. The EKI1 gene was isolated and used to construct eki1Delta and eki1Delta cki1Delta mutants. A multicopy plasmid containing the EKI1 gene directed the overexpression of ethanolamine kinase activity in wild-type, eki1Delta mutant, cki1Delta mutant, and eki1Delta cki1Delta double mutant cells. The heterologous expression of the S. cerevisiae EKI1 gene in Sf-9 insect cells resulted in a 165,500-fold overexpression of ethanolamine kinase activity relative to control insect cells. The EKI1 gene product also exhibited choline kinase activity. Biochemical analyses of the enzyme expressed in insect cells, in eki1Delta mutants, and in cki1Delta mutants indicated that ethanolamine was the preferred substrate. The eki1Delta mutant did not exhibit a growth phenotype. Biochemical analyses of eki1Delta, cki1Delta, and eki1Delta cki1Delta mutants showed that the EKI1 and CKI1 gene products encoded all of the ethanolamine kinase and choline kinase activities in S. cerevisiae. In vivo labeling experiments showed that the EKI1 and CKI1 gene products had overlapping functions with respect to phospholipid synthesis. Whereas the EKI1 gene product was primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway, the CKI1 gene product was primarily responsible for phosphatidylcholine synthesis via the CDP-choline pathway. Unlike cki1Delta mutants, eki1Delta mutants did not suppress the essential function of Sec14p.
MERLIN: a device diagnosis system based on analytic models (1993)

An approach to computer-aided interpretation of parametric test data for integrated circuit process-problem diagnosis is presented. In contrast to a conventional expert system, which reasons with a knowledge base consisting of rules acquired from human experts, the system presented centers its knowledge around analytic device equations. By using equations as the basis of the system knowledge, a more universal, well-organized, and concise level of knowledge is encoded. With the use of objects to present this knowledge, a great deal of useful information outside that described by only the symbolic expressions can be represented, and extension to qualitative or numeric models should be straightforward. The result is an expressive, well-organized, easily built, and easily maintained knowledge base. The authors describe the system's interactive graphical displays and the automatic data interpretation algorithms. Examples evaluating n-channel metal oxide semiconductor (NMOS) parameter variations, interconnect parameter variations, and interconnect yields are used for illustration.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The <i>Saccharomyces cerevisiae</i> histone H2A variant Htz1 is acetylated by NuA4 (2006)

The histone H2A variant H2A.Z (Saccharomyces cerevisiae Htz1) plays roles in transcription, DNA repair, chromosome stability, and limiting telomeric silencing. The Swr1-Complex (SWR-C) inserts Htz1 into chromatin and shares several subunits with the NuA4 histone acetyltransferase. Furthermore, mutants of these two complexes share several phenotypes, suggesting they may work together. Here we show that NuA4 acetylates Htz1 Lys 14 (K14) after the histone is assembled into chromatin by the SWR-C. K14 mutants exhibit specific defects in chromosome transmission without affecting transcription, telomeric silencing, or DNA repair. Function-specific modifications may help explain how the same component of chromatin can function in diverse pathways.
Methods to find the number of latent skills (2012)

Identifying the skills that determine the success or failure to exercises and question items is a difficult task. Multiple skills may be involved at various degree of importance. Skills may overlap and correlate. Slip and guess factors affect item outcome and depend on the profile of the student’s skill mastery and on item characteristics. In an effort towards the goal of finding the skills behind a set of items, we investigate two techniques to determine the number of salient latent skills. The Singular Value Decomposition (SVD) is a known technique to find latent factors. The singular values represent direct evidence of the strength of latent factors. Application of SVD to finding the number of latent skills is explored. A second technique is based on a wrapper approach. Linear models with different number of skills are built, and the one that yields the best prediction accuracy through cross validation is considered the most appropriate. The results show that both techniques are effective in identifying the latent factors of simulated data. Finally, an investigation with real data is reported. Both the SVD and wrapper methods yield results that have no simple interpretation, but one interpretation is consistent across the two methods, albeit not well aligned with the assessment of experts. 1.
Successful Application of Hypothermia Combined with Intra-Aortic Balloon Pump Support to Low-Cardiac-Output State After Open Heart Surgery (1996)

The authors report a successful application of hypothermia, along with intra-aortic balloon pump (IABP) support, to postcardiotomy ventricular failure. Surface-cooling hypothermia was applied in 8 patients after open heart surgery. The original cardiac procedure consisted of 3 aortocoronary bypass graftings (ACBGs), 2 aortic valve replacements (AVRs), 1 repair for left ventricular (LV) rupture after mitral valve replacement (MVR), 1 MVR + ACBG, and 1 MVR + AVR + tricuspid valve annuloplasty (TAP). Their ages ranged from fifty-two to sixty-eight years with a mean of sixty-one years. Hemodynamic criteria for induction of hypothermia included cardiac index (CI) less than 2.0 L/min/m2 with left atrial pressure greater than 18 mmHg despite the use of IABP and maximum pharmacologic support. Blood temperature was maintained at around 33 degrees C. By six hours after induction of hypothermia the tissue oxygen consumption decreased significantly with no hemodynamic deterioration as compared with that before cooling. The duration of hypothermia ranged from thirty-six to one hundred fifty-nine hours with a mean of seventy-eight hours. All 8 patients finally discontinued IABP support with a mean driving time of one hundred thirty-two hours. Five of them were ultimately discharged from the hospital and returned to their previous life-style. The authors believe that, from the perspective of monetary and personal resources, the use of hypothermia with IABP support could be a therapeutic option for patients with postcardiotomy ventricular failure.
Inhibition of Mycobacterium intracellulare by some vitamin K and coenzyme Q analogues. (1978)

Because vitamin K is present in several species of mycobacteria, and because coenzyme Q has been found to stimulate the growth of Mycobacterium tuberculosis and atypical mycobacteria, 8 quinones that can be considered to be dual analogues of vitamin K and coenzyme Q were tested for their activity against Mycobacterium intracellulare. One compound, 6-cyclo-octylamino-5,8-quinolinequinone (CQQ) exhibited considerable activity in vitro against several strains of Mycobacterium intracellulare at a concentration of 8 micrograms per ml. It has also shown evidence of bactericidal activity against growing cultures of Mycobacterium intracellulare. Time exposure studies indicated that a minimal contact period of 24 hours with a concentration of 8 micrograms of CQQ per ml is necessary for permanent inhibitory action against Mycobacterium intracellulare. At a concentration of 1 microgram per ml, CQQ inhibited Mycobacterium tuberculosis, including the rifampin-resistant strains. The drug has no activity against rapidly growing mycobacteria or organisms that are not acid-fast.
End-stage renal disease and diabetes catalyze the formation of a pentose-derived crosslink from aging human collagen. (1990)

Structure elucidation of a specific fluorophore from the aging extracellular matrix revealed the presence of a protein crosslink formed through nonenzymatic glycosylation of lysine and arginine residues. The unexpected finding that a pentose instead of a hexose is involved in the crosslinking process suggested that the crosslink, named pentosidine, might provide insight into abnormalities of pentose metabolism in aging and disease. This hypothesis was investigated by quantitating pentosidine in hydrolysates of 103 human skin specimens obtained randomly at autopsy. Pentosidine level was found to increase exponentially from 5 to 75 pmol/mg collagen over lifespan (r = 0.86, P less than 0.001). A three- to tenfold increase was noted in insulin-dependent diabetic and nondiabetic subjects with severe end-stage renal disease requiring hemodialysis (P less than 0.001). Moderately elevated levels were also noted in some very old subjects, some subjects with non-insulin dependent diabetes, and two subjects with cystic fibrosis and diabetes. The cause of the abnormal pentose metabolism in these conditions is unknown but may relate to hemolysis, impaired pentose excretion, cellular stress, and accelerated breakdown of ribonucleotides. Thus, pentosidine emerges as a useful tool for assessment of previously unrecognized disorders of pentose metabolism in aging and disease. Its presence in red blood cells and plasma proteins suggests that it might be used as a measure of integrated pentosemia in analogy to glycohemoglobin for the assessment of cumulative glycemia.
Characterization of Rhodosaminyl Transfer by the AknS/AknT Glycosylation Complex and Its Use in Reconstituting the Biosynthetic Pathway of Aclacinomycin A (2007)

The tetracyclic core of anthracycline natural products with antitumor activity such as aclacinomycin A are tailored during biosynthesis by regioselective glycosylation. We report the first synthesis of TDP-L-rhodosamine and demonstrate that the glycosyltransferase AknS transfers L-rhodosamine to the aglycone to initiate construction of the side-chain trisaccharide. The partner protein AknT accelerates AknS turnover rate for L-rhodosamine transfer by 200-fold. AknT does not affect the Km but rather affects the kcat. Using these data, we propose that AknT causes a conformational change in AknS that stabilizes the transition state and ultimately enhances transfer. When the subsequent glycosyltransferase AknK and its substrate TDP-L-fucose are also added to the aglycone, the disaccharide and low levels of a fully reconstituted trisaccharide form of aclacinomycin are observed.