gebhart/patrepeval huggingface dataset:
USB_SEC: A secure application to manage removable media (2016)

Nowadays securing data has become a prime concern for educational institutes, workplaces etc. USB drives are now largely used for storing and transferring data due to its large capacity at nominal cost, high-transferring rate and portability. These drives are not only used to store data but they also have the ability to run software programs and boot the operating systems. Besides several advantages, USB drives are being misused for stealing data and injecting viruses, Trojans and malicious software into the system. With the invent of U3 technology, which runs based on the auto-run facility of the operating system it has become possible to copy data without the owner's knowledge. This paper provides a solution to safeguard from data-thefts without using physical methods like using superglue to block the USB ports, without altering the registry values and without using Bios method.
Least-squares refinement with subsidiary conditions (1963)

A method of least-squares refinement is described in which the subsidiary conditions are treated like observational equations. The advantages of the method are its generality, its adaptability to machine computing, and the possibility of relaxing the subsidiary conditions to any desired degree by appropriate changes in the weighting. In suitable cases the method extends the range for which least-squares refinements converge to the correct solution.
Magnetocardiography provides non-invasive three-dimensional electroanatomical imaging of cardiac electrophysiology. (2007)

Since there is an increasing trend to favor interventional treatment of arrhythmias, clinical application of MCG 3D-EAI is foreseen to improve preoperative selection of patients, to plan the appropriate interventional approach and to reduce ablation failure.
Polysulfones: solid organic catalysts for the chemoselective cleavage of methyl-substituted allyl ethers under neutral conditions (2004)

The solid polysulfone made of SO2 and methylidenecyclopentane catalyzes the cleavage of methyl-substituted allyl ethers and liberates the corresponding alcohols.
Reverse search and related processing of gas chromatographic/mass spectrometric data from petroporphyrin analyses (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReverse search and related processing of gas chromatographic/mass spectrometric data from petroporphyrin analysesChristopher S. Hein, J. Philip. Gill, Richard P. Evershed, and Geoffrey. EglintonCite this: Anal. Chem. 1985, 57, 9, 1872–1879Publication Date (Print):August 1, 1985Publication History Published online1 May 2002Published inissue 1 August 1985https://doi.org/10.1021/ac00286a018RIGHTS & PERMISSIONSArticle Views68Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Get e-Alerts Get e-Alerts
Extracellular matrix regulates induction of alkaline phosphatase expression by ascorbic acid in human fibroblasts (2001)

During wound healing and inflammation, fibroblasts express elevated alkaline phosphatase (ALP), but are not in contact with collagen fibrils in the fibronectin (FN)-rich granulation tissue. We hypothesized that the extracellular matrix (ECM) environment might influence the induction of ALP in fibroblasts. Here we tested this hypothesis by studying the ALP-inductive response of normal human gingival fibroblasts to ascorbic acid (AsA). AsA induced ALP activity and protein in cells in conventional monolayer culture. This induction was inhibited by blocking-antibodies to the FN receptor alpha 5 beta 1 integrin and by the proline analog 3,4-dehydroproline (DHP). DHP prevented cells from arranging FN fibrils into a pericellular network and reduced the activity of cell spreading on FN. Plating of cells on FN facilitated the up-regulation by AsA of ALP expression, but did not substitute for AsA. In contrast, AsA did not cause ALP induction in cells cultured on and in polymerized type I collagen gels. Collagen fibrils inhibited the up-regulation by AsA of ALP expression in cells plated on FN. These results indicate that the ECM regulates the induction of ALP expression by AsA in fibroblasts: FN enables them to express ALP in response to AsA through interaction with integrin alpha 5 beta 1, whereas type I collagen fibrils cause the suppression of ALP expression and overcome FN.
Design and Implementation of Digital Up Converter for Homenet (2006)

Based on the classical system design flow, a custom digital up converter (DUC) IP is designed and implemented for Homenet system. At the system level, DUC behavior model is constructed and DUC system architecture, spectra distribution scheme and circuit parameters are confirmed with system modeling tool MATLAB. At the circuit level, the main function modules such as interpolator and numerically controlled oscillators (NCO) and so on are designed and implemented. Considering the limited hardware resources and performance specification, a large number of optimizing technologies and algorithm are adopted. At last, Homenet system verification flat including our custom digital up converter system is realized with Xilinx Virtexll XC2V1000-4FG256 FPGA.
Calcium dependent cyclic nucleotide phosphodiesterase is activated by poly(L-aspartic acid) (1985)

Ca2+-dependent cyclic nucleotide phosphodiesterase (Ca2+-PDE) activity was stimulated by poly(L-aspartic acid) but not by poly(L-glutamic acid), poly(L-arginine), poly(L-lysine), and poly(L-proline). This activation was Ca2+ independent and did not further enhance the activation of Ca2+-PDE by Ca2+-calmodulin (CaM). Poly(L-aspartic acid) produced an increase in the Vmax of the phosphodiesterase, associated with a decrease in the apparent Km for the substrate, such being similar to results obtained with Ca2+-CaM. Poly(L-aspartic acid) did not significantly stimulate myosin light chain kinase and other types of cyclic nucleotide phosphodiesterase. CaM antagonists such as N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), trifluoperazine, and chlorpromazine selectively antagonized activation of the enzyme by poly(L-aspartic acid). Kinetic analysis of W-7-induced inhibition of activation of phosphodiesterase by poly(L-aspartic acid) was in a competitive fashion, and the Ki value was 0.19 mM. On the other hand, prenylamine, another type of calmodulin antagonist that binds to CaM at sites different from the W-7 binding sites, did not inhibit the poly(L-aspartic acid)-induced activation of Ca2+-dependent cyclic nucleotide phosphodiesterase. These results imply that poly(L-aspartic acid) is a calcium-independent activator of Ca2+-dependent phosphodiesterase and that aspartic acids in the CaM molecule may play an important role in the activation of Ca2+-PDE.
Effective gray scale in lithographically scribed planar holographic Bragg reflectors (2004)

We demonstrate that holographic Bragg reflector grating structures, which are photolithographically scribed in planar waveguides, support a unique approach to apodization and overlay that uses fixed-depth etching and partial contour writing to achieve continuous reflective amplitude control.
Drag and Heat-Transfer Characteristics of Small Longitudinally Ribbed Surfaces (1979)

THE drag and heat-transfer characteristics of longitudinally ribbed surfaces have been examined for the case of a turbulent boundary layer. The purpose of the longitudinal fins is to confine the turbulent bursts to regions of small transverse extent, thus altering the local turbulence production. Rectangular, triangular, and razor blade rib geometries were examined. There was some indication that small drag reductions (< 4%) were obtained with two of the triangular grooved models, but further testing, consisting of detailed pitot and hot-wire surveys, is required for validation. The heat-transfer results indicated that several of the triangular grooved surfaces had heat-transfer increases 10% greater than the corresponding drag increases. These surfaces are unique in that heat-transfer augmentation results previously reported in the literature for airflows over external surfaces have always shown greater increases in drag than heat transfer.
Three-dimensional cell culture array using magnetic force-based cell patterning for analysis of invasive capacity of BALB/3T3/v-src (2009)

A three-dimensional (3D) cell culture system has been fabricated using a magnetic force based cell patterning method, demonstrating a facile approach for the analysis of invasive capacity of BALB/3T3/v-src using an magnetic force and magnetite nanoparticles. The 3D cell patterning was performed using an external magnetic force and a pin holder, which enables the assembly of the magnetically labeled cells on the collagen gel-coated surface as array-like cell patterns, resulting in the development of a 3D in vitro culture model. The cells embedded in type I collagen showed a compacted, spheroid like configuration at each spot, and distinct, accelerated cell growth was observed in cancer model cells compared with the control cells. The developed 3D cell culture array was applied to the susceptibility assay of the GM6001 matrix metalloproteinase (MMP) inhibitor, a collagenase inhibitor; a distinct suppression of cell proliferation was observed, while little change was observed in 2D. The developed 3D cell culture array system is useful to assess the effects of pharmacologic and/or microenvironmental influences on tumor cell invasion.
Deep kernel (2016)

Kernel function implicitly maps data from its original space to a higher dimensional feature space. Kernel based machine learning algorithms are typically applied to data that is not linearly separable in its original space. Although kernel methods are among the most elegant part of machine learning, it is challenging for users to define or select a proper kernel function with optimized parameter settings for their data. In this paper, we propose a novel method called Deep Kernel that can automatically learn a kernel function from data using deep learning. The deep kernel is currently utilized in classification, and dimension reduction and visualization. For the classification task, we evaluate the deep kernel method by comparing its performance with the optimized Gaussian kernels, both using support vector machines as the decision model, on different types of datasets. The experimental results show that the proposed deep kernel method outperforms the traditional methods with Gaussian kernels on most of the data sets. For the dimension reduction and visualization task, the deep kernel is used along with kernel PCA. The results are also compared and contrasted with using the RBF kernel with multiple parameters. The deep kernel is shown to be more powerful in dimension reduction and visualization than the RBF kernel.
Performance Evaluation of Behavioral Biometric Systems (2010)

We present, in this chapter, an overview of techniques for the performance evaluation of behavioral biometric systems. The BioAPI standard that defines the architecture of a biometric system is presented in the first part of the chapter. The general methodology for the evaluation of biometric systems is given including statistical metrics, definition of benchmark databases, and subjective evaluation. These considerations rely with the ISO/IEC19795-1 standard describing the biometric performance testing and reporting. The specificity of behavioral biometric systems is detailed in the second part of the chapter in order to define some additional constraints for their evaluation. This chapter is dedicated to researchers and engineers who need to quantify the performance of such biometric systems.
MACULAR INJURY BY A MILITARY RANGE FINDER (1999)

Objective: The authors report the clinical findings of a civilian patient who unintentionally looked into the laser beam of a military range finder. Detailed information on the range finder is given. The objective is to illustrate the potential danger of such devices and to give detailed information on the device, the clinical findings associated with exposure, and the laser-tissue interaction mechanism. Methods: The patient was examined with fluorescein angiography, indocyanine green angiography, microperimetry, and optical coherence tomography, both in the acute stage (2 hours) and 4 weeks later. Fluorescein angiography was performed again 4 months later. A total of 100 mg prednisone tapered over 9 days was prescribed. Additionally, 50 μg tissue plasminogen activator (TPA) and 0.5 mL pure C2F6 were injected in the vitreous. Results: In the acute phase, hemorrhage was located beneath the retina, primarily beneath the retinal pigment epithelium. Retinal defects as seen initially over the subretinal blood were reduced after 4 weeks, but a retinal defect ranging from the lasered site toward the fovea remained. Visual acuity slightly increased from 20/100 to 20/63 after 4 weeks. Indocyanine green angiography showed a large hypofluorescent spot in the macula. Four months after the accident, a classic choroidal neovascularization developed, originating from the lasered site. The technical parameters of the range finder were: Nd: YAG laser (1,064 nm), pulse duration 10 ns, beam divergence 1.5 mrad, energy 10 mJ. Conclusion: A range finder can produce severe macular injury. The primary laser–tissue interaction mechanism seems to be explosive disruption of choroidal tissue. Intravitreal injection of TPA and C2F6 did not show a clear benefit to such laser lesions. A late complication can be secondary choroidal neovascularization.
Novel laser beam steering techniques (2006)

The paper summarizes laser beam steering techniques for power beaming, sensing, and communication applications. Principles and characteristics of novel mechanical, micro-mechanical and non-mechanical techniques are compiled. Micro-lens based coarse beam steering in combination with liquid crystal or electro-optical phase control for fine steering is presented in more detail. This review addresses beam steering devices which modulate the phase distribution across a laser beam and excludes intra-cavity beam steering, beam steering based on combining tuneable lasers with dispersive optical elements, active optical phased arrays, and optical waveguides.
Anatomically Consistent Segmentation of Organs at Risk in MRI with Convolutional Neural Networks (2019)

Planning of radiotherapy involves accurate segmentation of a large number of organs at risk, i.e. organs for which irradiation doses should be minimized to avoid important side effects of the therapy. We propose a deep learning method for segmentation of organs at risk inside the brain region, from Magnetic Resonance (MR) images. Our system performs segmentation of eight structures: eye, lens, optic nerve, optic chiasm, pituitary gland, hippocampus, brainstem and brain. We propose an efficient algorithm to train neural networks for an end-to-end segmentation of multiple and non-exclusive classes, addressing problems related to computational costs and missing ground truth segmentations for a subset of classes. We enforce anatomical consistency of the result in a postprocessing step, in particular we introduce a graph-based algorithm for segmentation of the optic nerves, enforcing the connectivity between the eyes and the optic chiasm. We report cross-validated quantitative results on a database of 44 contrast-enhanced T1-weighted MRIs with provided segmentations of the considered organs at risk, which were originally used for radiotherapy planning. In addition, the segmentations produced by our model on an independent test set of 50 MRIs are evaluated by an experienced radiotherapist in order to qualitatively assess their accuracy. The mean distances between produced segmentations and the ground truth ranged from 0.1 mm to 0.7 mm across different organs. A vast majority (96 %) of the produced segmentations were found acceptable for radiotherapy planning.
PENGUIN-a Programmable, Extensible, Network Graphical User INterface (2002)

This paper presents a software module currently being used in AT&T for developing graphical user interfaces (GUIs) to telephony applications. We use the name PENGUIN, a Programmable, Extensible Network Graphical User INterface to refer to this reusable software module, which has been realized as both an X Window Intrinsics (Xt) widget and a UNIX* process. PENGUIN offers advantages of shorter development time, lower development cost and better quality over traditional GUI development methods for this class of problems. PENGUIN achieves this by encapsulating the (extensive) domain independent work involved with such GUIs, while being extensible to allow the application to integrate the domain dependent features it needs. PENGUIN has been used in a number of telephony applications including network maintenance, restoration, and provisioning. It has, in some instances, reduced the development time of domain dependent features from one person-year to well less than one person-month.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Inter-laboratory study of an optimised peptide mapping workflow using automated trypsin digestion for monitoring monoclonal antibody product quality attributes (2020)

Peptide mapping analysis is a regulatory expectation to verify the primary structure of a recombinant product sequence and to monitor post-translational modifications (PTMs). Although proteolytic digestion has been used for decades, it remains a labour-intensive procedure that can be challenging to accurately reproduce. Here, we describe a fast and reproducible protocol for protease digestion that is automated using immobilised trypsin on magnetic beads, which has been incorporated into an optimised peptide mapping workflow to show method transferability across laboratories. The complete workflow has the potential for use within a multi-attribute method (MAM) approach in drug development, production and QC laboratories. The sample preparation workflow is simple, ideally suited to inexperienced operators and has been extensively studied to show global applicability and robustness for mAbs by performing sample digestion and LC-MS analysis at four independent sites in Europe. LC-MS/MS along with database searching was used to characterise the protein and determine relevant product quality attributes (PQAs) for further testing. A list of relevant critical quality attributes (CQAs) was then established by creating a peptide workbook containing the specific mass-to-charge (m/z) ratios of the modified and unmodified peptides of the selected CQAs, to be monitored in a subsequent test using LC-MS analysis. Data is provided that shows robust digestion efficiency and low levels of protocol induced PTMs. Graphical abstract.
Tethering polypeptides through bifunctional PEG cross‐linking agents to probe protein function: Application to ATP synthase (2008)

Abstract Chemical crosslinking mediated by short bifunctional reagents has been widely used for determining physical relationships among polypeptides in multisubunit proteins, but less often for functional studies. Here we introduce the approach of tethering polypeptides by using bifunctional reagents containing a lengthy, flexible PEG linker as a form of crosslinking especially suited to functional analyses. The rotary molecular motor ATP synthase was used as a model subject. Single cysteine residues were introduced into selected positions of ATP synthase ϵ subunit, a component of the rotor subcomplex of the enzyme, and the unrelated maltose binding protein (MBP), then the two purified recombinant proteins were crosslinked by means of a dimaleimido‐PEG cross‐linking agent. Following purification, the ϵ‐PEG‐MBP was incorporated into membrane‐bound ATP synthase by reconstitution with ϵ‐depleted F 1 ‐ATPase and membrane vesicles that had been stripped of endogenous F 1 . ATP synthase reconstituted using ϵ‐PEG‐MBP had reduced ATP hydrolytic activity that was uncoupled from the pumping of H + , indicating the physical blockage of rotation of the γϵ c 10 rotor by the conjugated MBP, whereas enzyme reconstituted with ϵ‐PEG was normal. These results directly demonstrate the feasibility of studying mechanistic features of molecular motors through PEG‐based conjugation of unrelated proteins. Since tethering polypeptides provides a means of maintaining proximity without directly specifying or modifying interactions, application of the general method to other types of protein functional studies is envisioned. Proteins 2008. © 2008 Wiley‐Liss, Inc.
Plasma-assisted molecular beam epitaxy of GaN on porous SiC substrates with varying porosity (2003)

We have grown GaN on porous SiC substrates and studied the effect of substrate porosity on the overgrown film quality in terms of defect structure and density and film strain. The growth was performed by plasma-assisted molecular beam epitaxy. The GaN films were characterized by x-ray diffraction, transmission electron microscopy (TEM), and wafer curvature measurements by surface profilometry. TEM images show that the GaN film grown on porous substrates contains open tubes and a relatively low dislocation density in regions between tubes. We discuss various growth mechanisms that can lead to these defect features in the GaN film. However, we do not find any overall improvement in the x-ray rocking curve full width at half maximum of the GaN films grown on porous substrates compared to those on nonporous substrates. It was found that the GaN films grown on porous SiC were significantly more strain relaxed compared to those grown on nonporous substrate. We attribute this strain relaxation in part to the observed half-loop dislocations which form at the walls of the open tubes in the GaN films.
CMOS supporting circuitries for nano-oscillator-based associative memories (2012)

“Let physics do computing” is a promising approach to new-paradigm computing in the beyond CMOS era. Building associative memories based on the physics of nano oscillators, in particular, presents a lot of potential for intelligent information processing. In this paper, we discuss how CMOS supporting circuitries can interface the fabric of nano oscillators with digital computing world. Using CMOS ring oscillators to emulate the nano oscillator behavior, how to produce the associative memory function and to use it for image recognition is demonstrated by HSPICE simulation.
The Cutoff Wavelength of the TE/sub 10/ Mode in Ridged Rectangular Waveguide of Any Aspect Ratio (1966)

Design curves for ridged rectangular waveguides of the usual aspect ratio of 0.45 were published by Hopfer following earlier work carried out by Cohn and Marcuvitz. This paper has been written to extend the design data to ridged rectangular waveguides of any aspect ratio. An analysis of the error introduced by proximity effects has shown these to be of the order of a few percent.