gebhart/patrepeval huggingface dataset:
CONGENITAL VALVES AND DIVERTICULA OF THE ANTERIOR URETHRA (1969)

SUMMARY This report summarises the clinical findings and treatment of 17 examples of congenital anterior urethral valves and diverticula. Eight of the patients were under 2 years of age at the time of presentation, many of them had well‐marked urinary obstruction although it was seldom as severe as that seen in posterior urethral valves, and very much more satisfactory results attended surgical treatment. The diagnosis should be suspected in children with lower urinary tract obstruction and a palpable ventral penile swelling, and should be established by a voiding cysto‐urethrogram which visualises the entire urethra. The diagnosis may be confirmed by endoscopy when a sharp valvular ridge should be easily seen. An anterior urethral valve or diverticulum may be missed on a retrograde urethrogram. Surgical excision by a one‐ or two‐stage urethroplasty was the usual method of treatment. Ætiological series have been discussed.
Increasing dimethylarginine levels are associated with adverse clinical outcome in severe alcoholic hepatitis (2006)

Alcoholic hepatitis patients have higher portal pressures associated with increased ADMA, which may result from both decreased breakdown (decreased hepatic dimethylarginine-dimethylamino-hydrolase) and/or increased production. Elevated dimethylarginines may serve as important biological markers of deleterious outcome in alcoholic hepatitis.
Immunohistochemical and gelatin zymography studies for matrix metalloproteinases in bleomycin‐induced pulmonary fibrosis (1998)

The role of various matrix metalloproteinases (MMP) and tissue inhibitor of metalloproteinases-2 (TIMP-2), and the gelatinolytic activities of MMP involved in the process of bleomycin-induced pulmonary fibrosis in rabbits were investigated. Male Japanese white rabbits were intubated with tracheal tubes under anesthesia, and bleomycin hydrochloride in sterile saline or only sterile saline was administered through the tracheal tubes. The animals were killed 1, 3, 7, 14 and 28 days after the administration of bleomycin (n = 3) or saline (n = 2). Light microscopic immunohistochemistry for MMP-1 (interstitial collagenase), MMP-2 (gelatinase A), MMP-9 (gelatinase B) and TIMP-2 was performed. The gelatinolytic activities of lung tissue homogenates were studied by gelatin zymography. In the early stages, the gelatinolytic activity of MMP-9 was predominant. MMP-9 localized in the infiltrating neutrophils, macrophages, bronchial and bronchiolar epithelial cells. The alveolar epithelial basement membrane was frequently disrupted in the early stages, where MMP-9 possibly contributed to the disruption. In the late stages, the gelatinolytic activities of the latent and active forms of MMP-2 were predominant, and MMP-2 localized in the regenerated alveolar epithelial cells in addition to the bronchial epithelial cells. MMP-2, especially its active form, possibly plays a role in alveolar epithelial cell regeneration. The localization of MMP-1 was similar to that of MMP-9. TIMP-2 localized in the epithelial cells and in some fibroblasts in fibrotic lesions. TIMP-2 possibly plays a role in extracellular matrix deposition in balance with MMP.
Nonstationary learning characteristics of the LMS algorithm (1987)

Upper and lower bounding first-order linear recursions for the mean-squared error realized with the LMS algorithm subjected to a sequence of independent nonstationary training vectors are derived. These bounds coincide to give the exact evolution of mean-squared error for the problem of identification of a nonrecursive time-varying system with white-noise excitation. This leads to an exact formula for time-averaged mean-squared error that is used to study optimization of the step-size parameter for minimum time-average misadjustment. New results on dependence of the minimal step size and the minimum misadjustment on the degree of nonstationarity are obtained.
Inhibition of growth of established human glioma cell lines by modulators of the protein kinase-C system (1990)

The protein kinase-C (PKC) second messenger system contributes to regulation of cell growth and differentiation. This study was undertaken to examine the effects of modulators of the PKC enzyme system on the state of differentiation and proliferation rates of human gliomas in vitro. The administration of the PKC-activating phorbol esters 4-beta-phorbol-12,13-dibutyrate (PDB) and phorbol-12-myristate-13-acetate (PMA) resulted in a dose-related inhibition of growth of human glioma cell lines in vitro as measured by 3H-thymidine uptake. The synthetic nonphorbol PKC activator (SC-9) produced an even more pronounced decrease of 3H-thymidine uptake. Diacylglycerol, an endogenous activator of the system, applied externally, transiently decreased the proliferation, in concordance with its short-lived existence in vivo. Conversely, the administration of 4-alpha-phorbol-12,13-didecanoate (alpha-PDD), a phorbol ester that binds but does not activate the enzyme, had no effect on the proliferation rate. At the dosages that maximally decreased proliferation, there was no evidence of direct glioma cell lysis induced by these agents as measured by a chromium-release assay. Immunocytochemical analysis and cytofluorometric measurement of glial fibrillary acidic protein (GFAP) staining in the treated cultures revealed an increase in GFAP staining over control cultures. In contrast to the response of glioma cells, nonmalignant human adult astrocytes treated with the PKC activators responded by increasing their proliferation rate. The authors postulate that the diametrically opposed effects of PKC activators on nonmalignant astrocytes versus glioma growth may be due to a high intrinsic PKC activity in glioma cells, with resultant down-regulation of enzyme activity following the administration of the pharmacological activators.
Regulation of CTLA-4 expression during T cell activation (1996)

T cell activation requires at least two distinct signals, including signaling via the Ag-specific TCR and a costimulatory pathway. The best characterized costimulatory pathway involves the CD28 molecule, which is expressed constitutively on T cells and binds the family of B7 counter-receptors on APCs. Inhibition of this costimulatory pathway prevents T cell activation and can lead to long-term T cell unresponsiveness or anergy. In contrast, CTLA4, which is homologous to CD28, has been shown to be a negative regulator of T cell activation. The CTLA4 molecule is not expressed on resting T cells, but is induced after the initial steps of T cell activation. To address the regulation of CTLA4 expression, we have analyzed CTLA4 at the level of cell surface expression, mRNA, rate of transcription, and rate of decay of message. Nuclear runoff results show an increase in the rate of transcription following T cell activation. Our analyses of non-T cells, including B cells, mastocytoma, and fibroblasts, by Northern blot analysis detect only T cell expression of CTLA4. Reporter gene analysis indicates that 335 bp of upstream CTLA4 sequence are sufficient to control inducibility. We have identified important regulatory regions that control inducible and cell-specific CTLA4 expression. These results also suggest that both positive and negative response elements modulate the transcriptional regulation of CTLA4 gene expression. Understanding the regulation of CTLA4 should provide insight into the regulation of T cell activation at the molecular level.
Scalable Multiband Binaural Renderer for MPEG-H 3D Audio (2015)

To provide immersive 3D multimedia service, MPEG has launched MPEG-H, ISO/IEC 23008, “High Efficiency Coding and Media Delivery in Heterogeneous Environments.” As part of the audio, MPEG-H 3D Audio has been standardized based on a multichannel loudspeaker configuration (e.g., 22.2). Binaural rendering is a key application of 3D audio; however, previous studies focus on binaural rendering with low complexity such as IIR filter design for HRTF or pre-/post-processing to solve in-head localization or front-back confusion. In this paper, a new binaural rendering algorithm is proposed to support the large number of input channel signals and provide high-quality in terms of timbre, parts of this algorithm were adopted into the MPEG-H 3D Audio. The proposed algorithm truncates binaural room impulse response at mixing time, the transition point from the early-reflections to the late reverberation part. Each part is processed independently by variable order filtering in frequency domain (VOFF) and parametric late reverberation filtering (PLF), respectively. Further, a QMF domain tapped delay line (QTDL) is proposed to reduce complexity in the high-frequency band, based on human auditory perception and codec characteristics. In the proposed algorithm, a scalability scheme is adopted to cover a wide range of applications by adjusting the threshold of mixing time. Experimental results show that the proposed algorithm is able to provide the audio quality of a binaural rendered signal using full-length binaural room impulse responses. A scalability test also shows that the proposed scalability scheme smoothly compromises between audio quality and computational complexity.
Sentence reduction for automatic text summarization (2000)

We present a novel sentence reduction system for automatically removing extraneous phrases from sentences that are extracted from a document for summarization purpose. The system uses multiple sources of knowledge to decide which phrases in an extracted sentence can be removed, including syntactic knowledge, context information, and statistics computed from a corpus which consists of examples written by human professionals. Reduction can significantly improve the conciseness of automatic summaries.
Herpesvirus hominis type 2 infection in Ibadan. Problem of non-venereal transmission. (1980)

Examination of sera from blood donors, from patients attending a special treatment clinic, a family planning clinic, and an antenatal clinic showed that the prevalence of herpes virus hominis type 2 antibodies among the adult population in Ibadan is similar to that in other parts of the world. The possibility of non-venereal transmission of herpes virus infection was confirmed by the finding that herpesvirus hominis type 2 could survive on cloth samples under humid tropical conditions for long enough to allow transmission of infection via fomites.
The central region of HDM2 provides a second binding site for p53 (2006)

HDM2 is a negative regulator of p53 that inhibits its transcriptional activity and subjects it to degradation by an E3 ligase activity. The primary binding site for HDM2 on p53 is located in its N-terminal domain. A second site on the p53 core domain (p53C) binds to an unidentified site in HDM2. We found that this site is in its acidic domain and part of the zinc finger domain by examining the interaction of full-length and domain constructs of p53 with the N-terminal region of HDM2 and peptide arrays derived from the full-length protein. NMR spectroscopy showed that peptides derived from this region of HDM2 bound to residues in the specific DNA-binding site of p53C. The peptides were displaced from the site by gadd45 sequence-specific DNA. Phosphorylation of single amino acids in the central domain of HDM2 did not abolish the interaction between the HDM2-derived peptides and p53C. We speculate that this second binding site helps in stabilizing the interaction between HDM2 and p53 during p53 degradation.
Studies on the Tetramer of Chlorcyan and its Derivatives. III (1963)

Thermal decomposition of 2, 4-dichloro-6-a koxychloroisocyano-s-triazine, derived from chlorocyan tetramer (2, 4-dichloro-6-isocyanodichloro-s-triazine) above 140°c caused liberation of alkyl chloride easily and gave 2, 4-dichloro-6-isocyanate-striazine. This iso-cyanate was extremely unstable in the atmospheric moisture and decomposed immediately to 2, 4-dichloro-6-amino-s-triazine. The identification of this isocyanate was carried out by the following three methods : 1. Urethane was formed by the reaction with alcohol, 2. hydrolysis of 1 mol isocyanate gave 1 mol of ammelide, 1 mol carbon dioxide and two atoms of chlorine, and 3. infrared absorption spectra indicated the max. absorptions at 2, 260 cm-1 - 2200 cm-1 characteristic of isocyanate group.
Research and implementation of target tracking algorithm in compression domain on miniaturized DSP platform (2017)

The target tracking algorithm in compression domain based on compression perception is studied. To meet the specific application requirements, the shortcomings of original algorithm are improved. At the same time, based on the design idea and demand of miniaturized target position detector, a real-time image processing platform with TMS320DM6437 digital signal processor as the core is designed and implemented, and the algorithm is im-plemented and optimized on the DSP platform. The simulation and experiment results show that after the combination of Kalman filter, LBP feature and adding adaptive learning rate update strategy, the stability of the algorithm is improved. For the implementation in DSP, after a series of optimizing measures, as for an image with resolution of 960×960, taking the target window of 80×80 into account, the computation speed can be up to 25 fps, which can meet the requirement of real-time tracking. The embedded tracking system can track the selected moving objects continuously and stably, and can meet the target localization and tracking requirements under specific applications, which has a real practical value. Moreover, the method in this paper has a certain reference value for the research and applications of this kind of target tracking method in the embedded platform.
Mono- and Binuclear Rhodium Complexes of a Chiral 1,1-Diphosphine. Syntheses and Crystal Structures (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMono- and Binuclear Rhodium Complexes of a Chiral 1,1-Diphosphine. Syntheses and Crystal StructuresAngela Marinetti, Claude Le Menn, and Louis RicardCite this: Organometallics 1995, 14, 11, 4983–4985Publication Date (Print):November 1, 1995Publication History Published online1 May 2002Published inissue 1 November 1995https://doi.org/10.1021/om00011a006RIGHTS & PERMISSIONSArticle Views115Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (404 KB) Get e-AlertsSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Radial histograms as an aid in the inspection of circular objects (1985)

This paper considers the inspection of circular objects. Template matching forms a competitive approach for inspecting these products, but radial histograms are found to be especially useful whenever products are nearly symmetric. Various methods of renormalising radial histograms are compared, with particular reference to accuracy and resolution. It is shown that radial histogramming is valuable for checking quickly for various defects, and that it can lead to increased accuracy of radial measurement. Its capabilities depend strongly on the previous accurate location of the centres of circular regions: the Hough transform approach is well adapted to this purpose.
Hardware-based simplified discrete wavelet transform for detecting high-voltage spindles in neuron signals (2017)

This paper presents a hardware-based simplified discrete wavelet transform (Sim-DWT) that can detect high-voltage spindles (HVSs) in neuron signals. The Sim-DWT can operate at 125 kHz for detection within a spectrum of 5-15 Hz for HVS signals. Only 16 sample points are required as the window length for calculation. No multiplier is required in the Sim-DWT algorithm. The Sim-DWT was implemented in field programmable gate arrays, as well as being tested on real recorded neuron signals. The experimental results of the present study indicate that the hardware-based Sim-DWT algorithm can detect HVSs efficiently, and is suitable for implementation in low-power microcontrollers to serve as the digital core in a deep brain stimulator microsystem.
Application to Gel Termination Chromatography of Micro High Performance Liquid Chromatography (1980)

Abstract The raicroscale liquid chromatographic tecnnique was applied to gel perraination chromatography. As the results, the miniaturized GPC column requires smaller amounts of sample, packing materials and carrier solvent than those required with the ordinary GPC column, and it would be applicable to preparatory experiments to select the operation conditions for fractionation by GPC.
Investigation on the properties of magnesium oxychloride cement prepared with seawater (2019)

Seawater from South China Sea was used instead of freshwater to fabricate magnesium oxychloride cement (MOC). To study the basic performance of the seawater-mixed MOC paste, the setting time, hydration exothermic characteristics, compressive strength, thermal stability, seawater resistance, phase composition and microstructure of the paste were analysed in detail. The results showed that the use of seawater in the MOC paste slightly retarded the setting time and increased the total hydration heat. The compressive strength and thermal stability of the seawater-mixed MOC were slightly lower than those of the MOC paste prepared with freshwater. The main hydration product of both MOC pastes was 5Mg(OH) 2 .MgCl 2 .8H 2 O. The residual strength ratio of the seawater MOC paste was 9·70% higher than that of the freshwater MOC paste after 28 d immersion in seawater. However, the standard deviations suggest that the properties of MOC pastes prepared with seawater or freshwater were not significantly different.
Phasic and Long-Term Depression in Brainstem Nucleus Tractus Solitarius Neurons: Differing Roles of AMPA Receptor Desensitization (1997)

One important question concerning the homeostatic regulation of many physiological processes is whether the control mechanisms are purely reflexogenic or whether they may involve neural adaptation in the form of learning and memory in the brainstem. Using a brainstem slice preparation in the rat, we studied the modifiability of neural transmission in the first-order synapses of the medial and commissural nucleus tractus solitarius of the medulla. Sustained low-frequency stimulation (5 Hz) of primary afferent fibers in the tractus solitarius resulted in a phasic depression (accommodation) of synaptic strength as reflected by a concomitant decrease in the evoked excitatory postsynaptic potentials. In one group of neurons (type I), synaptic strength recovered rapidly after low-frequency stimulation, whereas in another group of neurons (type II), synaptic strength remained depressed for >30 min, i.e., manifesting long-term depression (LTD). The latter was switched into a short-term depression lasting 15-25 min after pharmacological blockade of NMDA receptor channels with D-APV or chelation of intracellular calcium ions with EGTA, whereas the accommodation phase was unaffected. Application of an AMPA receptor anti-desensitization agent cyclothiazide abolished the LTD, but not the accommodation response. These results suggest the presence of separate postsynaptic sites for the induction of LTD and accommodation, one being sensitive to cyclothiazide, whereas the other is not. Moreover, the maintenance of LTD is dependent on the level of intracellular Ca2+. These phasic and long-term synaptic plasticity in the nucleus tractus solitarius may play a role in the homeostatic regulation of cardiorespiratory functions.
Supporting Monitoring and Interruption Management in Complex Domains through Graded Multimodal Notifications. (2011)

Operators working in complex data-rich environments, such as air traffic control, need to cope with considerable, often competing, attentional demands. They experience data overload in vision and audition, are required to timeshare tasks, and need to manage unexpected changes and events. Current technologies fail to support them in handling these challenges. This has led to breakdowns in performance and, in some cases, accidents. The goal of the present research is to develop novel informative types of notifications that minimize unnecessary attention switching and better assist operators in attention management. They inform operators about the presence of an interruption as well as its urgency and location, thereby helping operators avoid performance costs associated with attention switching. Based on the assertion that information can be better processed in parallel if distributed across modalities, these notifications employ and combine two under-utilized modalities: touch and peripheral vision. They are graded, i.e., their salience varies over time, to reflect changes in the importance of attending to an interruption. Gradation was implemented either intra- or crossmodally (i.e., within or across peripheral vision and touch). The proposed designs were expected to improve the detection of unexpected events and the decision making about attention switching without significantly affecting performance on ongoing primary tasks. A series of studies were conducted to a) identify effective tactile notification designs, b) compare the effectiveness of peripheral visual and tactile notifications, and c) evaluate 5 notification schemes that employ peripheral vision and touch as well as gradation. The findings from this research show significantly improved interruption management and overall task performance for all cued over uncued conditions, especially in the case of crossmodally graded notifications. They contribute to the knowledge base in multimodal information processing and display design as well as attention/ interruption management. This work goes beyond earlier studies by comparing the robustness of peripheral visual and tactile notifications under high workload and by exploring not only intra- but also crossmodal gradation in interruption cueing. At an applied level, it suggests ways in which future ATC operations can be supported more effectively to ensure the continued safety of the air transportation system.
An Update on the Safety and Efficacy of Outpatient Plastic Surgery: A Review of 26,032 Consecutive Cases (2018)

Risk, III.