gebhart/patrepeval huggingface dataset:
The characteristics of I-125 4-IQNB and H-3 QNB in vivo and in vitro. (1984)

The accumulation of (R)-(H-3)-3-quinuclidinyl benzilate (H-3 QNB) and (R,S)-1-azabicyclo(2.2.2)oct-3-yl (R,S)-alpha-hydroxy-(4-[I-125]iodophenyl) benzeneacetate (I-125 4- IQNB ) in heart, caudate/putamen, and cerebellum of rats was determined at intervals from 15 min to 4 hr after injection. The behavior of the two radiotracers in the heart is consistent with in vitro results with respect to affinities and specificities. In the brain, however, the compounds differ in tissue selectivity. At high specific activity, neither compound provides localization that is consistent with the concentration of receptor in the tissues. The results of this study do not indicate quantification of receptor concentration by means of single external images.
The village health worker (2015)

The article lists what coordinators of village health teams (VHTs) in Uganda carry when they tour the countryside which includes a medicine box, timer and generic antimalarials.
Reconstitution of Purified VDAC1 into a Lipid Bilayer and Recording of Channel Conductance (2013)

The functional properties of purified voltage-dependent anion-selective channel protein 1 (VDAC1) have been examined in reconstituted systems based on artificially prepared phospholipid bilayers. The most widespread method for the characterization of the pore-forming activity of the mitochondrial VDAC1 protein requires reconstitution of the channel activity into a planar lipid bilayer (PLB) that separates two aqueous compartments. This system is able to produce a refined and large set of information on channel activity. The activity of the channel is reflected in the flow of ions (i.e., current) through a membrane that otherwise represents a barrier to ion flow. The setup thus requires the use of purified protein and a source of continuous current, as well as a sophisticated detector system able to amplify and record low, picoamper-level currents. This system is so efficient that the activity of even a single channel can be detected, allowing for study of VDAC1 at the molecular level.
Brain tumor segmentation by integrating symmetric property with region growing approach (2015)

Brain tumor segmentation is an important procedure for early diagnosis of brain tumor and planning of its treatment. However it is still a difficult task due to variations in size, shape and location of tumor. In this paper, we propose a novel brain tumor segmentation method using T2-weighted brain MR images by integrating symmetry property of brain with region growing approach. Bilateral symmetry property of brain is used in our method to identify various regions having probability of presence of the tumor. Identification of exact tumor location and its segmentation is then performed by using region growing technique. Qualitative and quantitative evaluation of proposed approach was performed and promising results have been demonstrated when compared with ground truth and other state of art method. The segmented tumor region obtained in our work can assist the doctors and radiologist in the diagnosis of brain tumor and treatment planning.
Effects of Syringe Material and Silicone Oil Lubrication on the Stability of Pharmaceutical Proteins (2014)

Currently, polymer-based prefillable syringes are being promoted to the pharmaceutical market because they provide an increased break resistance relative to traditionally used glass syringes. Despite this significant advantage, the possibility that barrel material can affect the oligomeric state of the protein drug exists. The present study was designed to compare the effect of different syringe materials and silicone oil lubrication on the protein aggregation. The stability of a recombinant fusion protein, abatacept (Orencia), and a fully human recombinant immunoglobulin G1, adalimumab (Humira), was assessed in silicone oil-free (SOF) and silicone oil-lubricated 1-mL glass syringes and polymer-based syringes in accelerated stress study. Samples were subjected to agitation stress, and soluble aggregate levels were evaluated by size-exclusion chromatography and verified with analytical ultracentrifugation. In accordance with current regulatory expectations, the amounts of subvisible particles resulting from agitation stress were estimated using resonant mass measurement and dynamic flow-imaging analyses. The amount of aggregated protein and particle counts were similar between unlubricated polymer-based and glass syringes. The most significant protein loss was observed for lubricated glass syringes. These results suggest that newly developed SOF polymer-based syringes are capable of providing biopharmaceuticals with enhanced physical stability upon shipping and handling.
Solution of a Fab (26-10)/digoxin complex by generalized molecular replacement (1991)

The structures of a Fab fragment of a monoclonal murine antidigoxin antibody (26-10) complexed with digoxin and of a mutant of the Fab itself have been solved by molecular replacement. The solution strategy employed a generalization of molecular replacement. Prior to translation searches, a large number of the highest rotation-function peaks were subjected to a rigid-body refinement against the linear correlation coefficient between intensities of observed and calculated structure factors in which first the overall orientation of the model and then the orientations and translations of the individual domains (VH, VL, CH1 and CL) were refined. This procedure clearly identified the correct orientation of the search model. Furthermore, it produced a significant and unambiguous solution for the translation search. After rigid-body refinement, the R factor was in the low forties at 8-2.5 and 8-2.7 A resolution for the Fab mutant and the Fab/digoxin complex, respectively. One round of simulated annealing refinement of all atomic positions reduced the R factor to the low twenties in both cases.
Tamoxifen induces oxidative stress and apoptosis in oestrogen receptor-negative human cancer cell lines (1998)

Recent data have demonstrated that the anti-oestrogen tamoxifen (TAM) is able to facilitate apoptosis in cancer cells not expressing oestrogen receptor (ER). In an attempt to identify the biochemical pathway for this phenomenon, we investigated the role of TAM as an oxidative stress agent. In two ER-negative human cancer cell lines, namely T-leukaemic Jurkat and ovarian A2780 cancer cells, we have demonstrated that TAM is able to generate oxidative stress, thereby causing thiol depletion and activation of the transcriptional factor NF-kappaB. As described for other oxidative agents, TAM was able to induce either cell proliferation or apoptosis depending on the dose. When used at the lowest dose tested (0.1 microM), a slight proliferative effect of TAM was noticed in terms of cell counts and DNA synthesis rate, whereas at higher doses (10 microM) a consistent occurrence of apoptosis was detected. Importantly, the induction of apoptosis by TAM is not linked to down-regulation or functional inactivation by phosphorylation of the antiapoptotic bcl-2 protein.
Confined Mixing of Multiple Jets (1974)

This study deals with the transfer of kinetic energy from an array of primary jets to a surrounding secondary stream. It explores the basic features of such flows and examines to what extent the results of single jet research may be applied to multiple jet configurations. It presents an analytical technique for estimating the performance of multiple jets and examines in a special multiple-jet test facility the validity of the assumptions used in the analysis. In addition, performance data are presented for a multiple array of 31 primary jets of 1/2 in. ID in a 12 in. ID mixing chamber covering a range of jet velocities up to 186 ft/sec and primary to secondary flow velocity ratios from 2.8:1 to 5:1.
A Missing Sensor Data Estimation Algorithm Based on Temporal and Spatial Correlation (2015)

In wireless sensor network, data loss is inevitable due to its inherent characteristics. This phenomenon is even serious in some situation which brings a big challenge to the applications of sensor data. However, the traditional data estimation methods can not be directly used in wireless sensor network and existing estimation algorithms fail to provide a satisfactory accuracy or have high complexity. To address this problem, Temporal and Spatial Correlation Algorithm (TSCA) is proposed to estimate missing data as accurately as possible in this paper. Firstly, it saves all the data sensed at the same time as a time series, and the most relevant series are selected as the analysis sample, which improves efficiency and accuracy of the algorithm significantly. Secondly, it estimates missing values from temporal and spatial dimensions. Different weights are assigned to these two dimensions. Thirdly, there are two strategies to deal with severe data loss, which improves the applicability of the algorithm. Simulation results on different sensor datasets verify that the proposed approach outperforms existing solutions in terms of estimation accuracy.
Speeding up fractal image encoding bywavelet-based block classification (1996)

The authors propose a novel fast fractal image encoding algorithm using wavelet-based block classfication. The range blocks and corresponding domain blocks are classified into edge selective categories by the energy compacted wavelet coefficients. The searching is carried out between the same classes for range-domain comparisons which significantly reduces the computational complexity. Experimental results show that the proposed method can speed up the fractal image encoding process by up to 12.3 times over the conventional full search method.
Hydrogen-Bond Acceptor and Donor Properties of Divalent Sulfur (<i>Y</i>-S-<i>Z</i> and <i>R</i>-S-H) (1997)

The hydrogen-bond acceptor ability of divalent sulfur in Y —S— Z systems, Y , Z = C, N, O or S, and the donor ability of thiol S—H have been studied using crystallographic data retrieved from the Cambridge Structural Database. Of 1811 Y —S— Z substructures that co-occur with N—H or O—H donors, only 86 (4.75%) form S...H—N,O bonds within S...H < 2.9 Å. In dialkylthioethers, the frequency of S...H bond formation is 6.24%, but drops below 3% when the alkyl groups are successively replaced by C sp 2 centres. This parallels an increasing \delta-positivity of S as calculated using ab initio methods. A similar frequency trend is observed for O...H—N,O bond formation by analogous oxyethers. Mean intermolecular >S...H distances for O—H [2.67 (3) Å] and N—H [2.75 (2) Å] donors (with H positions normalized to neutron values) are ca 0.25 Å longer than in C=S...H—N,O systems, indicative of very weak hydrogen bonding to >S. Intramolecular >S...H are slightly more frequent (8.56%), with S...H slightly shorter than for the intermolecular case. In contrast, 26 (70.3%) out of 37 S—H donors that co-occur with suitable acceptors form X ...H—S bonds. The C=O...H—S system is predominant with a mean O...H distance of 2.34 (4) Å, considerably longer (weaker) than in C=O...H—O systems.
High Viscosity Oil Challenges in a Burgan Reservoir of South East Kuwait (2014)

Abstract The initial charge history due to two source rocks Makhul and Kazdumi caused a special distribution of heavy components in the Greater Burgan field. There is also strong evidence that water washing, supported by the strong edge water drive, can explain the occurrence of high viscosity oil in several wells that are positioned in areas of paleo oil-water contact. The challenge was to map high viscosity oil for Burgan reservoirs for further development and planning. Greater Burgan field is producing mainly from Burgan reservoirs and remaining oil maps are updated yearly on the basis of highest known water (HKW) contact using PNC logs. To produce from bypassed oil (oil below HKW) is a challenge especially for Lower Burgan reservoir due to presence of highly viscous oil. A study was done to identify and map high viscosity oil. MDT data including mobility and gradient was used to validate heavy oil pay flags. The next challenge was to see any movement of heavy oil on the basis of shift in the latest PNC log. Previous works on high viscosity oil focused mainly on its occurrence within one hundred feet of original oil water contact. This work mapped high viscosity oil for all the Burgan reservoirs, and then integrated with MDT data for validation. Another new aspect was the detection of movement of high viscosity oil due to production using Sigma logs and mapping them for each reservoir. This work has helped identify high viscosity oil within the bypassed oil zone of Lower Burgan reservoir to help in development planning for high viscosity oil. Yearly tracking of high viscosity oil expected in upcoming wells has greatly helped in advanced planning for relevant data acquisition. A program including MDT and ultra-slow pump rate for fluid sampling is planned to improve the reliability of prediction.
The Use of Hydroxyapatite Bone Cement for Sinus Floor Augmentation With Simultaneous Implant Placement in the Atrophic Maxilla. A Report of 10 Cases (2000)

According to this preliminary study, the hydroxyapatite bone cement appears to hold great promise as a grafting alloplastic material for sinus floor augmentations. Its main advantage is its ability to provide initial stability required for osseointegration and proper implant location and parallelism. Further clinical and histological studies are required before it can be recommended for routine use in sinus lift procedures.
Encryption and hash based security in Internet of Things (2015)

The Internet of Things (IoT) promises to be the next big revolution of the World Wide Web. It has a very wide range of applications, ranging from smart cities, smart homes, monitoring radiation levels in nuclear plants, animal tracking, health surveillance and a lot more. When nodes in wireless sensor networks are monitored through internet it becomes a part of Internet of Things. This brings in a lot of concerns related to security, privacy, standardization, power management. This paper aims at enhancing security in smart home systems. Devices like thermostat, air conditioners, doors and lighting systems are connected with each other and the internet through the internet of things technologies. Encryption and hash algorithms are proposed in this paper through which devices in the IoT can securely send messages between them. Encryption algorithm is used to ensure confidentiality as the attackers cannot interpret the cipher text that is sent. In order to ensure integrity (cipher text is not changed) hash algorithm is used.
The characteristic of photoluminescence of tris‐(7‐substituted‐8‐hydroxyquinoline) aluminum complexes and polymeric complexes (2003)

Abstract The 7‐allyl‐ and 7‐(2‐methylvinyl)‐functionalized derivatives of 8‐hydroquinoline are synthesized by Claisen rearrangement and double bond rearrangement respectively. Then 7‐allyl‐8‐hydroquinoline (C) and 7‐(2‐methylvinyl)‐8‐hydroquinoline (D) are reacted with aluminum chloride to afford the corresponding tris‐(7‐allyl‐8‐hydroxyquinoline) aluminum complex (F) and tris‐(7‐(2‐methylvinyl)‐8‐hydroxyquinoline) aluminum complex (G). The photoluminescence of complex (F) or (G), compared with that of tris‐(8‐hydroxyquinoline) aluminum complex (E), all showed a red shift in emission wavelengths in different solvents, such as chloroform, hexane and ethanol. For two substituents containing an external double bond, the 2‐methylvinyl group gives a larger red shift in the emission wavelength than the allyl group. The X‐ray crystal structure indicates that 7‐(2‐methylvinyl)‐8‐hydroxyquinoline (D) is a trans‐isomer. The styrene and 7‐allyl‐8‐hydroxyquinoline copolymer, and the styrene and 7‐(2‐methylvinyl)‐8‐hydroxyquinoline copolymer are also reported. Further reactions of the copolymer are then performed by adding aluminum(III) chloride and ligands 8‐hydroxyquinoline. The spectroscopic characteristics of these aluminum(III) polymeric complexes are discussed. Copyright © 2003 John Wiley & Sons, Ltd.
Purification and characterization of Vibrio cholerae non-O1 heat-stable enterotoxin (1986)

A toxin which causes rapid fluid accumulation in a suckling mouse assay and which was produced by Vibrio cholerae non-O1 was investigated. The toxin was purified from the culture supernatant of V. cholerae non-O1 (strain A-5) by ammonium sulfate fractionation, hydroxyapatite treatment, ethanol extraction, column chromatographies on SP-Sephadex C-50 and DEAE-Sephadex A-25, and high-pressure liquid chromatography on a Lichrosorb RP-8 column. About 1.4 X 10(5)-fold purification was achieved, with a recovery of about 12%. Although the crude preparation was heat labile, the purified toxin was heat stable. The minimum effective dose of purified toxin was about 5 ng in the suckling mouse assay. The amino acid composition of the purified toxin was determined to be Asp(3), Glu(1), Ala(1), half-Cys(6), Ile(2), Leu(1), Phe(1), and Pro(1). These data show the production of a new type of heat-stable enterotoxin (NAG-ST) by V. cholerae non-O1.
RECONSTRUCTION OF DOMAIN BOUNDARY AND CONDUCTIVITY IN ELECTRICAL IMPEDANCE TOMOGRAPHY USING THE APPROXIMATION ERROR APPROACH (2011)

With clinical measurements, knowledge about the body shape is usually uncertain. Since the use of an incorrect model domain in the measurement model is bound to lead to severe estimation errors, one possibility is to estimate both the conductivity and parametrization of the domain boundary. This could in principle be carried out using the Bayesian inversion paradigm and Markov chain Monte Carlo sampling, but such an approach would lead in clinical situation to an impractical solution because of the excessive computational complexity. In this paper, we adapt the so-called approximation error approach for approximate recovery of the domain boundary and the conductivity. In the approximation error approach, the modeling error caused by an inaccurately known boundary is treated as an auxiliary noise process in the measurement model and sample statistics for the noise process are estimated based on the prior models of the conductivity and boundary shape. Using the approximation error model, we reconstruct the conductivity and a low rank approximation for the realization of the modeling error, and then recover an approximation for the domain boundary using the joint distribution of the modeling error and the boundary parametrization. We also compute approximate spread estimates for the reconstructed boundary. We evaluate the approach with simulated examples of thorax imaging and also with experimental data from a laboratory setting. The reconstructed boundaries and posterior uncertainty are feasible; in particular, the actual domain boundaries are essentially within the posterior spread estimates.
Is alpha‐synuclein in the colon a biomarker for premotor Parkinson's Disease? Evidence from 3 cases (2012)

This is the first demonstration of alpha-synuclein in colon tissue prior to onset of PD. Additional study is required to determine whether colonic mucosal biopsy may be a biomarker of premotor PD.
Cytolethal Distending Toxins Require Components of the ER-Associated Degradation Pathway for Host Cell Entry (2014)

Intracellular acting protein exotoxins produced by bacteria and plants are important molecular determinants that drive numerous human diseases. A subset of these toxins, the cytolethal distending toxins (CDTs), are encoded by several Gram-negative pathogens and have been proposed to enhance virulence by allowing evasion of the immune system. CDTs are trafficked in a retrograde manner from the cell surface through the Golgi apparatus and into the endoplasmic reticulum (ER) before ultimately reaching the host cell nucleus. However, the mechanism by which CDTs exit the ER is not known. Here we show that three central components of the host ER associated degradation (ERAD) machinery, Derlin-2 (Derl2), the E3 ubiquitin-protein ligase Hrd1, and the AAA ATPase p97, are required for intoxication by some CDTs. Complementation of Derl2-deficient cells with Derl2:Derl1 chimeras identified two previously uncharacterized functional domains in Derl2, the N-terminal 88 amino acids and the second ER-luminal loop, as required for intoxication by the CDT encoded by Haemophilus ducreyi (Hd-CDT). In contrast, two motifs required for Derlin-dependent retrotranslocation of ERAD substrates, a conserved WR motif and an SHP box that mediates interaction with the AAA ATPase p97, were found to be dispensable for Hd-CDT intoxication. Interestingly, this previously undescribed mechanism is shared with the plant toxin ricin. These data reveal a requirement for multiple components of the ERAD pathway for CDT intoxication and provide insight into a Derl2-dependent pathway exploited by retrograde trafficking toxins.
PLANTEAN LA NECESIDAD DE UN TRATAMIENTO MÁS RESPONSABLE DE LA SEXUALIDAD EN LOS MEDIOS (1998)

EN LA FACULTAD DE CIENCIAS POLITICAS Y SOCIALES SE REALIZO LA MESA REDONDA USO Y ABUSO DEL LENGUAJE SEXUAL EN LA PANTALLA Y EN LA RADIO, COORDINADA POR LA MAESTRA DALIA CHARGOY, COMO PARTE DEL TRABAJO FINAL DE SUS ALUMNOS LA COMUNICACION COMO PROCESO. EN SU INTERVENCION, LA DOCTORA ESTHER CORONA, DIRECTORA DE LA ASOCIACION MEXICANA DE EDUCACION SEXUAL Y SEXOLOGIA, DIJO QUE TANTO LOS PROFESIONALES DE LOS MEDIOS DE COMUNICACION COMO QUIENES TRABAJAN CON LA SEXUALIDAD COMO MATERIA DE ESTUDIO DEBERIAN SUJETARSE A UN CODIGO DE ETICA. ELLO NO IMPLICA NECESARIAMENTE UNA FORMA DE CENSURA, PUNTUALIZO, SINO UN CONJUNTO DE VALORES A LOS QUE ASPIRAMOS TODOS. POR SU PARTE, EL LICENCIADO REYES NUNEZ BERCINI, SECRETARIO ACADEMICO DEL CENTRO UNIVERSITARIO DE ESTUDIOS CINEMATOGR FICOS, SE REFIRIO A LA SEXUALIDAD Y EL CINE.
What a Blast!: A Massive MIMO Radar System for Monitoring the Surface in Steel Industry Blast Furnaces (2017)

The main goal of surfacegauging radar applications is to obtain a complete image of a surface area inside a closed and possibly tightly sealed container filled with materials having sufficient reflectivity for highfrequency electromagnetic waves. Radar systems are applicable where standard acoustical or optical measurement techniques are strongly impaired due to harsh environmental conditions-such as extreme dust, heat, occasional heavy humidity, and aggressive chemicals-that occur, for example, inside a fully operative blast furnace.
The Application of the Alternating Procedure of H.A. Schwarz for Computing Three-Dimensional Electrostatic Fields in Electron-Optical Systems (1984)

The numerical solution of three-dimensional electrostatic field problems in electron-optical devices with complicated boundaries requires the use of very large and fast computers. A numerical counterpart of the Alternating Procedure by H. A. Schwarz (SAP) makes efficient use of both storage space and time available on the computer and therefore represents a useful new method in this context. In this method. the domain of solution is decomposed into independent subdomains where the appropriate individual methods of solution may be chosen. Correspondingly. the original boundary value problem is decomposed into a sequence of boundary value problems in these subdomains. SAP requires no explicit influence matrix and uses little storage space. Time requirements depend essentially on the methods applied in the respective subregions. SAP is particularly useful in obtaining analytical formulas for field distributions in "large" regions of empty space (such as in fringe field regions). Numerical results obtained with a computer program treating an electrostatic quadrupole lens problem show that a high degree of accuracy can be obtained with this method.