gebhart/patrepeval huggingface dataset:
Internal-node waveform probing of MMIC power amplifiers (2002)

A novel internal-node waveform probing technique has been demonstrated on a MMIC. The error of the measurement and its perturbance to circuit operation was estimated and verified to be less than 20%. Valuable insight was obtained from the variation of waveforms as a function of frequency, drive and location.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Stimulated Brillouin scattering in dispersion-decreasing fiber with ultrahigh-speed femtosecond soliton pulse compression (2005)

We report that stimulated Brillouin scattering (SBS) in a dispersion-decreasing fiber (DDF) is particularly disadvantageous with ultrahigh-speed femtosecond soliton compression that exceeds 40 GHz. It is important to note that the increase in the longitudinal mode power of a soliton is proportional to the square of the repetition rate. The SBS threshold is determined by the dispersion-decreasing rate of the DDF, rather than its fiber loss. We suppressed the SBS by applying 30-MHz frequency modulation to a mode-locked fiber laser and successfully obtained a stable 40-GHz, 100-fs pulse train.
Exploring the binding affinities of p300 enzyme activators CTPB and CTB using docking method. (2010)

CREB binding protein (CBP) and E1A binding protein p300, also known as p300 are functionally related transcriptional co-activators (CoAs) and histone acetyltransferases (HATs). Some small molecules, which target HATs can activate or inhibit the p300 enzyme potently. Here, we report the binding affinities of two small molecules CTPB [N-(4-chloro-3-trifluoromethyl-phenyl)-2-ethoxy-6-pentadecyl-benzamide] and CTB [N-(4-chloro-3-trifluoromethyl-phenyl)-2-ethoxybenzamide] with p300 using docking method to obtain the insight of their interaction with p300. These small molecules bind to the enzyme, subsequently causing a structural change in the enzyme, which is responsible for the HAT activation. CTB exhibits higher binding affinity than CTPB, and their lowest docked energies are -7.72, -1.18 kcal/mol, respectively. In CTPB molecule, phenolic hydroxyl of Tyr1397 interacts with the non-polar atoms C(5E) and C(5F), and forms polar-non polar interactions. Similar interactions have also been observed in CTB. The residues Tyr1446 and Cys1438 interact with the non-pentadecyl atoms. Further, the docking study predicts a N-H--O hydrogen bonding interaction between CTB and Leu1398, in which the H--O contact distance is 2.06 A. The long pentadecyl chain of CTPB reduces the formation of hydrogen bond with the p300. The H-bond interaction could be the key factor for the better activation of CTB.
Sensorless parameter estimation and current‐sharing strategy in two‐phase and multiphase IPOP DAB DC–DC converters (2018)

A sensorless current‐sharing strategy for two‐phase and multiphase input‐parallel output‐parallel (IPOP) DC–DC converters is proposed here. A dual‐active‐bridge (DAB) DC–DC converter is chosen as the basic DC–DC converter. With this strategy in two‐phase IPOP DAB DC–DC converters, the parameter mismatches between phases are estimated by perturbing the duty cycle in one phase and measuring the changes of duty cycles in both phases, then the duty cycles are adjusted to compensate the mismatches, thus achieving current sharing without current sensor. With this strategy in multiphase IPOP DAB DC–DC converters, by perturbing the duty cycles in ( N − 1) out of N phases in turn and measuring the changes of duty cycles, respectively, the parameter mismatches among phases are estimated. According to the mismatches, a set of variables, which are proportional to the per‐phase output currents, are calculated. Then with a current‐sharing regulator, parameter mismatches are compensated, thus achieving current sharing without current sensor. The validity and feasibility of the proposed sensorless current‐sharing strategy are verified through both simulation and prototype experimental results.
Survival of childhood polycystic kidney disease following renal transplantation: The impact of advanced hepatobiliary disease (2003)

Childhood PKD encompasses the diagnoses of AR and ADPKD, glomerulocystic disease, and syndromes such as tuberous sclerosis or Jeune's syndrome. Given the fact that a majority of PKD children with ESRD carry the diagnosis of ARPKD, natural history studies assessing the long-term prognosis of PKD patients following renal transplantation must focus on morbidity and mortality issues related to complications from congenital hepatic fibrosis. Using the NAPRTCS registry, we analyzed the patient and graft survival rates of 203 PKD patients and 7044 non-PKD patients undergoing renal transplantation between 1987 and 2001. Deceased PKD patients, all with a diagnosis of ARPKD, were further identified and characterized using a special questionnaire submitted to the principal investigators. Overall graft and patient survival rates were not significantly different between PKD and non-PKD patients. No differences in rates of acute rejection or time to first rejection were noted between PKD and non-PKD patients. The relative risk of living longer than 3 yr in the PKD patients was not significantly different from non-PKD patients (RR = 0.70, p = 0.28). Sepsis was identified as a likely factor in the cause of death in nine (64%) ARPKD patients and was comfirmed with a positive blood culture in four patients. Despite similar graft and patient survival rates among PKD and non-PKD children following renal transplantation, our results suggest that ARPKD transplant recipients appear to be at increased risk for sepsis that may be related to hepatic fibrosis and ascending cholangitis. The utility of early liver transplantation in ARPKD patients with significant hepatobiliary disease is discussed.
Correlations between topological resonance energy of methyl-substituted benz[c]acridines, benzo[a]phenothiazines and chrysenes, and their carcinogenic or antitumor activities. (1996)

In order to clarify the effects of methyl substitution on the carcinogenic activity, each resonance energy (RE) of benz[c]acridines, benzo[a]phenothiazines, chrysene, and their methyl derivatives was calculated by Aihara's TRE theory. Some correlations seem to exist between the values of resonance energy per pi-electron for the cationic species-with the lack of the atom having the highest approximate superdelocalizability (Sr'(E)) from their parents skeleton-and carcinogenic activity.
Bayesian model-based inference of transcription factor activity (2007)

We demonstrate that full Bayesian inference is appropriate in this application and has several benefits over the maximum likelihood approach, especially when the volume of data is limited. We also show the benefits of using a non-linear model over a linear model, particularly in the case of repression.
Simulating the electrical behavior of cardiac tissue using the bidomain model. (1993)

The complex microstructure of cardiac muscle comprised of coupled cells, enveloped by an interstitium made up of blood vessels, connective tissue, and fluid, presents some obvious problems to those interested in understanding the tissue as an electrical medium. One approach that has gained considerable favor in recent years views the tissue not as a discrete structure, but rather as two coupled, continuous domains: one for the intracellular space and the other for the interstitial space. For convenience, the averaged potentials and currents in both domains are defined at every point in space. The structure is partially preserved by assigning a conductivity tensor at each point. One advantage of using this space-averaged model is that the governing equations for the electric fields can be described by partial differential equations that on occasion lead to analytical solutions. This formal treatment of cardiac tissue as two coupled continua is referred to as the bidomain model. This article presents a mathematical description of the bidomain model and reviews the use of the model for simulating the electrical behavior of cardiac tissue.
Pharmacodynamic Interaction between Propofol and Remifentanil Regarding Hypnosis, Tolerance of Laryngoscopy, Bispectral Index, and Electroencephalographic Approximate Entropy (2004)

Remifentanil alone is ineffective at ablating response to stimuli but demonstrates potent synergy with propofol. BIS and AE values corresponding to 95% probability of ablating response are influenced by the combination of propofol and remifentanil to achieve this endpoint, with higher propofol concentrations producing lower values for BIS and AE.
An optimal nonblocking multicast virtual circuit switch (2002)

This paper describes an architecture for a multicast virtual circuit switch using cell recycling. This is the first nonblocking switch architecture that is optimal in both the switching network complexity and the amount of memory required for routing cells in multicast virtual circuits. Furthermore, it is optimal in the amount of effort required for multicast virtual circuit modification. This architecture makes it both technically and economically feasible to construct the large switching systems that will ultimately be needed for wide scale deployment of broadband ISDN to residential users.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Taxonomy of honeynet solutions (2015)

Honeynet research has become more important as a way to overcome the limitations imposed by the use of individual honeypots. A honeynet can be defined as a network of honeypots following certain topology. Although there are at present many existing honeynet solutions, no taxonomies have been proposed in order to classify them. In this paper, we propose such taxonomy, identifying the main criteria used for its classification and applying the classification scheme to some of the existing honeynet solutions, in order to quickly get a clear outline of the honeynet architecture and gain insight of the honeynet technology. The analysis of the classification scheme of the taxonomy allows getting an overview of the advantages and disadvantages of each criterion value. We later use this analysis to explore the design space of honeynet solutions for the proposal of a future optimized honeynet solution.
Tandem Thiol Switch Synthesis of Peptide Thioesters via N–S Acyl Shift on Thiazolidine (2011)

An efficient "thiol switch" approach for the synthesis of peptide thioesters via an acid-catalyzed N-S acyl shift and a thioester exchange reaction in tandem with concurrent removal of protecting groups is described. This method employs novel 2-(thiomethyl)thiazolidine (TMT)-anchored resins and is fully compatible with Fmoc chemistry.
Integrated Thermal Conductivity Vacuum Sensor (1996)

A thermal conductivity vacuum sensor with a novel on-chip control system is presented. The sensing structure is a small circuit suspended over a cavity etched in the substrate. An integrated control system maintains a constant temperature difference between this thermally isolated sensor and the substrate. The control loop allows for a digitally adjustable operating temperature of the sensing structure. The range of the vacuum sensor extends from 0.8 Pa (6 mTorr) to approximately 9.2x10 4 Pa (690 Torr). The system was fabricated in a completely unmodified foundry CMOS process, dissipates only 5 mW of power, and occupies an area of approximately 0.3 mm 2
Inhibition of the 26 S Proteasome by Polyubiquitin Chains Synthesized to Have Defined Lengths (1997)

Ubiquitin is a covalent signal that targets cellular proteins to the 26 S proteasome. Multiple ubiquitins can be ligated together through the formation of isopeptide bonds between Lys<sup>48</sup> and Gly<sup>76</sup> of successive ubiquitins. Such a polyubiquitin chain constitutes a highly effective proteolytic targeting signal, but its mode of interaction with the proteasome is not well understood. Experiments to address this issue have been limited by difficulties in preparing useful quantities of polyubiquitin chains of uniform length. We report a simple method for large scale synthesis of Lys<sup>48</sup>-linked polyubiquitin chains of defined length. In the first round of synthesis, two ubiquitin derivatives (K48C-ubiquitin and Asp<sup>77</sup>-ubiquitin) were used as substrates for the well characterized ubiquitin-conjugating enzyme E2-25K. Diubiquitin blocked at the nascent proximal and distal chain termini was obtained in quantitative yield. Appropriately deblocked chains were then combined to synthesize higher order chains (tetramer and octamer in the present study). Deblocking was achieved either enzymatically (proximal terminus) or by chemical alkylation (distal terminus). Chains synthesized by this method were used to obtain the first quantitative information concerning the influence of polyubiquitin chain length on binding to the 26 S proteasome; this was done through comparison of different length (unanchored) polyubiquitin chains as inhibitors of ubiquitin-conjugate degradation.<i>K</i> <sub>0.5</sub> was found to decrease ∼90-fold, from 430 to 4.8 μm, as the chain was lengthened from two to eight ubiquitins. The implications of these results for the molecular basis of chain recognition are discussed.
Putrescine and cadaverine formation in vacuum packed beef (1985)

Bacterial numbers, putrescine and cadaverine concentrations and pH were measured at regular intervals during the chill storage of vacuum packed beef. Odours on opening the packs were also assessed. Cadaverine concentration increased more rapidly than that of putrescine and measurable increases were evident before maximum bacterial numbers were attained and before any permanent off-odours were detected. Diamine concentrations correlated better with total viable count (TVC) than with counts of Gram negative organisms.
Reflex sensors for telemedicine applications (2008)

A solution is sought for the measurement of human deep tendon reflexes as part of a comprehensive patient condition monitoring system for use in a telemedicine context.This study focused on the development, testing and performance evaluation of a prototype compact patellar tendon reflex measurement system that is able to provide a quantitative reflex evaluation for use by medical practitioners and in a telemedicine environment.A prototype system was developed that makes use of Xsens MTx orientation sensors, force-sensing resistors and an electromyogram (EMG) to measure the reflex response.Suitable parameters identified for analysis included the change in pitch, angular velocity and acceleration of the lower leg, the EMG response, the tendon impact, and various latencies associated with these measurements.Other information considered included the age, mass, and physical dimensions of the test subject.Clinical testing was performed to collect data to evaluate the system performance.Subjective reflex evaluations were conducted by three doctors according to a standard reflex grading scale using video recordings of the tests.Self-organizing maps and multi-layer feed-forward (MLFF) artificial neural networks (ANNs) were used to analyze the collected data with the aim of pattern identification, data classification and reflex grading prediction.It was found that the MLFF network delivered the correct reflex grading with an accuracy of 85%, which was of the same order as the rate of differences between the subjective reflex evaluations performed by the doctors (80%).Furthermore, analysis of the data suggested that certain parameters were not necessary for the autonomous evaluation, such as EMG data and the tendon impact.The use of ANNs to analyze a reflex measurement as proposed by this study offers an accurate, repeatable and concise representation of the reflex that is familiar to doctors and suitable for use in a general clinical setting or for telemedicine purposes.
Interaction of nitrogen with vacancy defects in N+-implanted ZnO studied using a slow positron beam (2005)

ZnO crystals were implanted with N+, O+, and Al+, and co-implanted with O+∕N+ and Al+∕N+ ions. Positron annihilation measurements indicate introduction of vacancy clusters upon implantation. In the N+-implanted and Al+∕N+ co-implanted samples, these vacancy clusters are only partially annealed at 800°C, as compared with their entire recovery in the O+- and Al+-implanted samples at 800–900°C, suggesting a strong interaction between nitrogen and vacancy clusters. However, in the O+∕N+ co-implanted sample, most vacancy clusters disappear at 800°C. Probably oxygen scavenges nitrogen to enhance the annealing of the vacancy clusters. Upon further annealing at 1000–1100°C, nitrogen also forms stable complexes with thermally generated vacancies. These nitrogen-related vacancy complexes need high-temperature annealing at 1200–1250°C to be fully removed.
A Fibrin Patch-Based Enhanced Delivery of Human Embryonic Stem Cell-Derived Vascular Cell Transplantation in a Porcine Model of Postinfarction Left Ventricular Remodeling (2010)

Abstract It is unknown how to use human embryonic stem cell (hESC) to effectively treat hearts with postinfarction left ventricular (LV) remodeling. Using a porcine model of postinfarction LV remodeling, this study examined the functional improvement of enhanced delivery of combined transplantation of hESC-derived endothelial cells (ECs) and hESC-derived smooth muscle cells (SMCs) with a fibrin three-dimensional (3D) porous scaffold biomatrix. To facilitate tracking the transplanted cells, the hESCs were genetically modified to stably express green fluorescent protein and luciferase (GFP/Luc). Myocardial infarction (MI) was created by ligating the first diagonal coronary artery for 60 minutes followed by reperfusion. Two million each of GFP/Luc hESC-derived ECs and SMCs were seeded in the 3D porous biomatrix patch and applied to the region of ischemia/reperfusion for cell group (MI+P+C, n = 6), whereas biomatrix without cell (MI+P, n = 5), or saline only (MI, n = 5) were applied to control group hearts with same coronary artery ligation. Functional outcome (1 and 4 weeks follow-up) of stem cell transplantation was assessed by cardiac magnetic resonance imaging. The transplantation of hESC-derived vascular cells resulted in significant LV functional improvement. Significant engraftment of hESC-derived cells was confirmed by both in vivo and ex vivo bioluminescent imaging. The mechanism underlying the functional beneficial effects of cardiac progenitor transplantation is attributed to the increased neovascularization. These findings demonstrate a promising therapeutic potential of using these hESC-derived vascular cell types and the mode of patch delivery.
Polysomes and Protein Synthesis in Cells Infected with a DNA Virus (1966)

In HEp-2 cells infected with herpes simplex virus the rate of protein synthesis at first decline, is stimulated between 4 and 8 hours after infection, and progressively and irreversibly declines from 9 to 16 hours later. The increase and decrease in rates coincide with corresponding changes in the amounts of cytoplasmic polysomes and amounts of labeled amino acids in nascent peptides bound to polysomes. The data indicate that (i) early and late inhibition and intervening stimulation of protein synthesis are due to the corresponding breakdown and formation of polysomes, and (ii) the bulk of viral proteins is probably made on cytoplasmic polysomes.
An improved method of intralamellar keratoplasty in rats. (1987)

Intralamellar keratoplasty in inbred rats is a valuable method for the investigation of corneal allograft rejection. Present methods of intralamellar corneal grafting are tedious and time-consuming. In addition, induction of neovascularization, a prerequisite to inducing graft rejection, is variable. In an effort to overcome these problems, the authors have developed an improved method of intralamellar keratoplasty. Intralamellar pockets are formed by introducing a 30-g needle into the corneal stroma near the limbus. Approximately 10-25 microliters of lipopolysaccharide (LPS) (100 micrograms/ml) is injected into the stroma, forming a stromal bleb. This bleb is incised to form a pocket, resulting in the leakage of the injected liquid. The intralamellar pocket formation is completed by dissecting any remaining stromal fibers in the area of former bleb. Once the pocket has been formed, grafts of corneal tissue are inserted, and the incision is closed. This method of keratoplasty has the following advantages over previously reported methods: (1) It is more rapid and less tedious because the formation of the corneal bleb protects the anterior chamber from being invaded during the corneal incision; (2) It leads to a reproducible induction of neovascularization in every cornea so treated; (3) It results in a higher frequency of allograft rejection.
Context and Environment (2008)

This chapter contains sections titled: How Context and Environment Influence Body Language Same Body Language, Different Perceptions When Body Language and Context Are in Conflict Chapter 4 Takeaways Chapter 4 Worksheet
BREVIARIO: PRESENTACIÓN DE LIBRO (2004)

DURANTE LA PRESENTACION DEL LIBRO CONCURSOS MERCANTILES. DOCTRINA, LEY Y JURISPRUDENCIA, DE ARCELIA QUINTANA, DEL INSTITUTO DE INVESTIGACIONES JURIDICAS (IIJ), DIEGO VALADES, DIRECTOR DE ESTE INSTITUTO, MANIFESTO QUE ESTE TEXTO NO SOLO ES UTIL PARA EL PROFESOR DE DERECHO MERCANTIL, PARA EL ABOGADO QUE LITIGA EN ESA MATERIA, PARA EL ESTUDIANTE O PARA EL JUZGADOR; TAMBIEN LO ES PARA TODO EL QUE TIENE INTERES EN TEMAS JURIDICOS. EN EL AUDITORIO DE LA SEDE ALTERNA DE LA SUPREMA CORTE DE JUSTICIA DE LA NACION (SCJN), MARIANO AZUELA GITRON, PRESIDENTE DE LA SCJN, DESTACO QUE ESTA OBRA CONTRIBUYE AL PERFECCIONAMIENTO DEL ORDEN JURIDICO DEL PAIS PORQUE ES DE UNA GRAN ACTUALIDAD. VIVIMOS UN MUNDO GLOBALIZADO EN EL QUE LO ECONOMICO OCUPA UN LUGAR IMPORTANTE. Y SI BIEN NO ES EL CENTRO DE LA VIDA HUMANA, SI TIENE QUE SER DELIMITADO ADECUADAMENTE EN LAS LEYES.