gebhart/patrepeval huggingface dataset:
Enabling Arbitrary Wavelength Optical Frequency Combs on Chip (2015)

A necessary condition for generation of bright soliton Kerr frequency combs in microresonators is to achieve anomalous group velocity dispersion (GVD) for the resonator modes. This condition is hard to implement in visible as well as ultraviolet since the majority of optical materials are characterized with large normal GVD in these wavelength regions. We overcome this challenge by borrowing ideas from strongly dispersive coupled systems in solid state physics and optics. We show that photonic compound ring resonators can possess large anomalous GVD at any desirable wavelength, even if each individual resonator is characterized with normal GVD. Based on this concept we design a mode locked frequency comb with thin-film silicon nitride compound ring resonators in the vicinity of Rubidium D1 line (794.6nm) and propose to use this optical comb as a flywheel for chip-scale optical clocks.
CD4+ T cells contribute to postischemic liver injury in mice by interacting with sinusoidal endothelium and platelets (2006)

The mechanisms by which T cells contribute to the hepatic inflammation during antigen-independent ischemia/reperfusion (I/R) are not fully understood. We analyzed the recruitment of T cells in the postischemic hepatic microcirculation in vivo and tested the hypothesis that T cells interact with platelets and activate sinusoidal endothelial cells, resulting in microvascular dysfunction followed by tissue injury. Using intravital videofluorescence microscopy, we show in mice that warm hepatic I/R (90/30-140 min) induces accumulation and transendothelial migration of CD4+, but not CD8+ T cells in sinusoids during early reperfusion. Simultaneous visualization of fluorescence-labeled CD4+ T cells and platelets showed that approximately 30% of all accumulated CD4+ T cells were colocalized with platelets, suggesting an interaction between both cell types. Although interactions of CD4+/CD40L-/- T cells with CD40L-/- platelets in wild-type mice were slightly reduced, they were almost absent if CD4+ T cells and platelets were from CD62P-/- mice. CD4 deficiency as well as CD40-CD40L and CD28-B7 disruption attenuated postischemic platelet adherence in the same manner as platelet inactivation with a glycoprotein IIb/IIIa antagonist and reduced neutrophil transmigration, sinusoidal perfusion failure, and transaminase activities. Treatment with an MHC class II antibody, however, did not affect I/R injury. In conclusion, we describe the type, kinetic, and microvascular localization of T cell recruitment in the postischemic liver. CD4+ T cells interact with platelets in postischemic sinusoids, and this interaction is mediated by platelet CD62P. CD4+ T cells activate endothelium, increase I/R-induced platelet adherence and neutrophil migration via CD40-CD40L and CD28-B7-dependent pathways, and aggravate microvascular/hepatocellular injury.
VLA‐1: a T cell surface antigen which defines a novel late stage of human T cell activation (1985)

The VLA-1 protein complex defines a previously undescribed very late stage of activated T cell differentiation, following either alloantigen or mitogen activation. This protein appears after 2-3 weeks of activation, considerably later than the early T cell activation antigens such as the interleukin 2 (IL 2) receptor, transferrin receptor, 4F2 antigen, T10 and HLA-DR, and has therefore been termed very late antigen-1 (VLA-1). Unlike the IL 2 receptor, VLA-1 expression does not require restimulation with antigen, and in fact, VLA-1 expression was high on T cells that had lost their IL 2 receptors. Expression of VLA-1 was found on all or nearly all long-term-activated T cells including T4+ and T8+ clones, bulk cultures, long-term T cells from adults and newborns and long-term T cells maintained in pure or crude IL 2 preparations. VLA-1 was also found on HTLV-1 infected T cell populations. Immunoprecipitation experiments confirmed that the VLA-1 protein complex (210 000/130 000 Mr) can be co-expressed with another protein complex called VLA-2 (165 000/130 000 Mr) on the same T cell clones. However, co-expression was not obligatory because in some long-term cultures little or no VLA-2 was present relative to VLA-1. Because VLA-1 defines a novel late stage of T cell activation, being present on all or most all types of long-term activated T cells, and not on any other cell types in peripheral blood, it has unique potential as a marker for activated T cells in vivo and may provide a clue towards elucidating novel long-term T cell functions or growth requirements of this late stage of T cell differentiation.
Fixation of Multifragmentary Patella Fractures Using a Bilateral Fixed-angle Plate (2013)

This biomechanical study is the first to compare 3 fixation methods-bilateral fixed-angle plate, modified anterior tension wiring, and cannulated lag screws with anterior tension wiring-in multifragmentary distal patella fractures. A T-shaped 3-part fracture simulating a multifragmentary articular distal patella fracture (AO/OTA 34-C2.2) was created in 18 human cadaver knee specimens. Three groups were created using homogenous ages and bone mineral densities based on the fixation method received. Repetitive testing over 100 cycles was performed by moving the knee against gravity from 90° flexion to full extension. Failure was defined as fracture displacement greater than 2 mm. In all patellae using fixed-angle plates, an anatomical fracture reduction could be maintained throughout cyclic testing, whereas anterior tension wiring and lag screws with tension wiring showed significant fracture displacement after 100 cycles, with mean fracture gaps of 2.0±1.3 and 1.9±1.6 mm, respectively. The differences in fracture gaps between the fixed-angle plate group and the other 2 groups were statistically significant. In both groups using tension wiring, half of the constructs (3 of 6 in each group) failed due to a fracture displacement greater than 2 mm. The bilateral fixed-angle plate was the only fixation method that sustainably stabilized a multifragmentary articular distal patella fracture during cyclic loading when compared with modified anterior tension wiring and cannulated lag screws with anterior tension wiring.
Cognitive correlates of supratentorial atrophy on MRI in multiple sclerosis (2001)

These volume/function relationships presumably reflect the effects of subcortical axonal and myelin loss on the neural networks that subserve cognition. If serial MRI volume estimations can index accumulating cognitive deficits, this simple technique may be useful in therapeutic trials.
Polymer−Clay Nanocomposites from Directly Micellized Polymer/Toluene in Water and Their Characterization by WAXD and Solid-State NMR Spectroscopy (2003)

Polymer−clay nanocomposites with hydrophobic-polymer matrixes, such as polystyrene or poly(methyl methacrylate), were prepared from dispersed unmodified clay and directly surfactant-micellized polymer/toluene in one pot. The mixing of clay and hydrophobic polymer is evidenced by a large long period of ca. 4 nm as observed by wide-angle X-ray diffraction. Two-dimensional 1H−29Si NMR experiments with 1H spin diffusion confirm the proximity of clay, surfactant, and a significant polymer fraction on the 5-nm scale.
Priority Based Job Scheduling Techniques In Cloud Computing: A Systematic Review (2013)

Abstract: Cloud Computing is the use of computing resources (Hardware and Software) that are delivered as a service over a network (typically the internet) to the customers. It intends to share large scale equipments and resources for computation, storage, information and knowledge for scientific researches [1]. In cloud computing, there are many jobs requires to be executed by the available resources to achieve best performance, minimal total time for completion, shortest response time, utilization of resource usage and etc. Because of these different objectives and high performance of computing environment, we need to design, develop, propose a scheduling algorithm to outperform appropriate allocation map of jobs due to different factors. In job scheduling priority is the biggest issue because some jobs need to scheduled first then the other jobs which can wait for a long time. In this paper, a systematic review of various priority based job scheduling algorithms is presented. These algorithms have different perspective, working principles etc. This study concludes that all the existing techniques mainly focus on priority of jobs and reduces service response time and improving performance etc. There are many parameters that can be mentioned as factor of scheduling problem to be considered such as load balancing, system throughput, service reliability, service cost, service utilization and so forth.
Silica Sprays Reduce the Incidence and Severity of Bract Necrosis in Poinsettia (1996)

Silica sprays (Na 2 SiO 3 or SiO 2 · n H 2 O) markedly reduced the incidence and severity of bract necrosis (BN) of Euphorbia pulcherrima Willd. cv. Supjibi Red compared to plants not sprayed with silica. BN has been associated with low Ca concentrations or high K: Ca ratios in tissues of bract margins. Silica had no effect on Ca or K concentrations in bract margin tissues, and BN was not associated with the macro- or micronutrient composition of bract margin tissues. Sixteen days after initial anthesis, nontreated and deionized-water-sprayed poinsettias developed a higher incidence of BN than did plants sprayed with Na 2 SiO 3 or CaCl 2 . However, sprays of 3.56, 5.34, and 7.12 m m Na 2 SiO 3 were as effective as 9.98 m m CaCl 2 sprays in protecting against BN of `Supjibi Red' and `Angelika White' bracts for up to 30 days after initial anthesis. `Supjibi Red' developed a higher incidence of bract necrosis than did `Angelika White', but both cultivars showed a similar response to the treatments and similar symptoms of necrosis. In both cultivars, initial symptoms appeared as small necrotic lesions on bracts at the looped ends of lateral veins that displayed a closed-vein pattern after the plants reached initial anthesis.
Five-Year Outcomes After Prostatectomy or Radiotherapy for Prostate Cancer: The Prostate Cancer Outcomes Study (2004)

At 5 years after diagnosis, men treated with radical prostatectomy for localized prostate cancer continue to experience worse urinary incontinence than men treated with external beam radiotherapy. However, the two treatment groups were more similar to each other with respect to overall sexual function, mostly because of a continuing decline in erectile function among the external beam radiotherapy patients between years 2 and 5.
Synthetic Studies on 2,5-Diarylisoxazolidin-3-ones (1992)

3-Aryl-3-bromopropanoyl chloride in either ether or carbon tetrachloride reacted with 2 equiv. of hydroxylamine in the absence of trimethylsilyl chloride at ambient temperature to give directly 2,5-diarylisoxazolidin-3-ones in good yields. However, when 3-benzylhydroxylamine at , N-benzyl-3-bromo-3-phenylpropanohydroxamic acid (72%) and N-benzyl-C-phenylnitrone (12%) were obtained. On the contrary, 3-phenylisoxazolidin-5-one (41%) and 2-benzyl-S-phenyl-isoxzolidin-3-one (38%) were obtained when 3 equiv. of benzylhydroxylamine was used under the same conditions.
Protective CD4<sup>+</sup>and CD8<sup>+</sup>T Cells against Influenza Virus Induced by Vaccination with Nucleoprotein DNA (1998)

DNA vaccination is an effective means of eliciting both humoral and cellular immunity, including cytotoxic T lymphocytes (CTL). Using an influenza virus model, we previously demonstrated that injection of DNA encoding influenza virus nucleoprotein (NP) induced major histocompatibility complex class I-restricted CTL and cross-strain protection from lethal virus challenge in mice (J. B. Ulmer et al., Science 259:1745-1749, 1993). In the present study, we have characterized in more detail the cellular immune responses induced by NP DNA, which included robust lymphoproliferation and Th1-type cytokine secretion (high levels of gamma interferon and interleukin-2 [IL-2], with little IL-4 or IL-10) in response to antigen-specific restimulation of splenocytes in vitro. These responses were mediated by CD4+ T cells, as shown by in vitro depletion of T-cell subsets. Taken together, these results indicate that immunization with NP DNA primes both cytolytic CD8+ T cells and cytokine-secreting CD4+ T cells. Further, we demonstrate by adoptive transfer and in vivo depletion of T-cell subsets that both of these types of T cells act as effectors in protective immunity against influenza virus challenge conferred by NP DNA.
Shakespeare Die Idee des Menschseins in Seinen Werken. (1955)

Kurt Schilling, Shakespeare Die Idee des Menschseins in Seinen Werken Get access Shakespeare Die Idee des Menschseins in seinen Werken. By Kurt Schilling. München/Basel: Ernst Reinhardt Verlag, 1953. Pp. 294. 16 Swiss Francs bound in linen. Hereward T. Price Hereward T. Price University of San Francisco Search for other works by this author on: Oxford Academic Google Scholar Shakespeare Quarterly, Volume 6, Issue 2, Spring 1955, Pages 188–189, https://doi.org/10.2307/2866406 Published: 01 April 1955
Assessment of the abuse liability of buspirone in recreational sedative users. (1982)

The abuse potential of buspirone, a new dopaminergic antianxiety drug, was evaluated by assessing its subjective effects in standard (10 mg) and high (40 mg) doses. These were compared with methaqualone (300 mg), diazepam (20 mg and 10 mg), and placebo in 24 casual recreational sedative users. Addiction Research Center Inventory scales measuring euphoria, sedation, dysphoria, and abuse liability were used as dependent measures. Groups of subjects received all treatments in randomized order in six weekly 4-hour sessions. Compared to placebo, methaqualone caused elevated scores on euphoria, physical sedation, and abuse liability scales compared to placebo, while 40 mg buspirone caused increased physical sedation, increased physical and mental dysphoria, and lower abuse liability scores. Overall, buspirone at 40 mg appeared unlikely to be reinforcing to recreational illicit drug users; the 10 mg dose was not discriminable from placebo or 10 mg diazepam. Diazepam at 20 mg showed some euphoriant effect compared to placebo.
Teaching thermal design of power electronic systems with web-based interactive educational software (2004)

For designing reliable power electronic systems it is essential to understand basic thermal issues like the stationary and transient relation of the power semiconductor losses the junction temperature and the application of thermal equivalent circuits. Also, thermal properties are of special importance in connection with further increasing the compactness of power converter systems. The aim of this paper is to give an introduction into the basic theory of heat energy conduction and thermal design which should serve as an addition to the Java applets compiled in a the iPES-Thermal, a module of the interactive educational software iPES which is freely available at www.ipes.ethz.ch and employed at the ETH Zurich for supporting an introductory course on power electronics.
MMSE transmitter design for correlated MIMO systems with imperfect channel estimates: power allocation trade-offs (2006)

We investigate the transmit precoder design problem for a multiple input multiple output (MIMO) link with correlated receive antennas, considering the effect of channel estimation. We work with the total mean squared error (MSE) as the performance measure, and develop transceiver structures considering the effect of channel estimation and the correlation of the MIMO link. The proposed transceiver structures are optimum in the sense of minimizing the total MSE and distributing the total MSE equally among the parallel data streams. Motivated by the substantial effect the channel estimation process can have on the system performance, we next investigate the problem of how the correlated MIMO link should distribute its total available power between power expended for channel estimation versus data transmission. The optimum power allocation problem between the training sequences for channel estimation and data transmission for the correlated MIMO link is shown to have a unique solution, that is different than the uncorrelated case. It is observed that the proposed transceiver achieves near-minimum MSE values via a relatively wide range of power allocation parameters. This is in contrast to the transceiver that is oblivious to the estimation errors when a more precise power allocation strategy is needed to achieve the best performance. Our results demonstrate that the correlation structure of the MEMO link has a profound effect on the performance, and that the transceiver optimization should be done by taking both the correlation and the channel estimation process into account
Optimal control of axial xenon oscillation in PWR based on on-line data processing of axial offsets. (1991)

In a large pressurized water reactor (PWR), xenon oscillations can occur due to the variation of xenon distribution in the reactor. Horizontal and axial modes of oscillation are known. The former is of less concern because of its convergence but the latter can be divergent. Sometimes xenon oscillations are intentionally introduced to obtain recalibration data for the nuclear instrumentation system and in this case oscillations must be eliminated after the data acquisition as soon as possible. Many studies and experiments have been made on control of xenon oscillations, and this problem was solved clearly from the theoretical points of view on the reactor physics and control. However it is found that fine control is required within actual plant constraints to apply the principles and control laws to be indicated from the previous studies. From this point of view a new method has been developed for providing clear operating instructions to the reactor operator.Here, the new method is based on online data processing of axial offsets and the validity of the method has been evaluated through numerical simulations. Then the method has been applied to the experiments in actual PWRs and it has also been proved to be quite effective.
Adsorption of Moisture and Organic Contaminants on Hafnium Oxide, Zirconium Oxide, and Silicon Oxide Gate Dielectrics (2003)

Hafnium oxide and zirconium oxide are two high-κ materials having the potential to replace silicon oxide as the gate dielectric. Atmospheric molecular contamination can affect the quality of the new gate dielectric film in a manner similar to Characterization of contaminant adsorption behavior of these high-κ films should assist in deciding their potential for successful integration in silicon metal oxide semiconductor technology. The interaction of moisture and organics (in particular, isopropanol, IPA) as common interfacial contaminants with a 5 nm film deposited by atomic layer chemical vapor deposition (ALCVD), which is a trademark of ASM International) is investigated using atmospheric pressure ionization mass spectrometry (APIMS); the kinetics and mechanism are compared to that of and and have similar moisture adsorption loading, but are significantly higher than that of However, almost all the adsorbed moisture can be removed from and after a 300°C bake under nitrogen purge, whereas surfaces retain 20-30% of the adsorbed moisture. Experiments with IPA show that the adsorption loading on the three surfaces has the following order: A multilayer model for adsorption of water and IPA is developed to understand the mechanism of interactions of contaminants with the three surfaces. Results from the application of this multilayer model to the experimental data indicate that forms the strongest surface-hydroxyl (X-OH) bond. © 2003 The Electrochemical Society. All rights reserved.
MicroRNA Profile Predicts Recurrence after Resection in Patients with Hepatocellular Carcinoma within the Milan Criteria (2011)

MicroRNA profiling can predict HCC recurrence in Milan criteria cases.
Sub-Nyquist medical ultrasound imaging: En route to cloud processing (2013)

In medical ultrasound imaging, a pulse of known shape is transmitted into the respective medium, and the received echoes are sampled and digitally processed in a way referred to as beamforming to form an ultrasound image. Applied spatially, beamforming allows to improve resolution and signal-to-noise ratio. The structure of medical ultrasound signals allow for significant reduction of both sampling and processing rates by relying on ideas of Xampling, sub-Nyquist sampling and frequency domain beamforming. In this paper we present an implementation on an ultrasound machine using sub-Nyquist sampling and processing and the obtained imaging results. The provided system configuration exploits the advantages of beamforming in the frequency domain, which is performed at a low-rate. Our results prove that the concept of porting heavy computational tasks to the cloud is feasible for medical ultrasound, leading to potential of considerable reduction in future ultrasound machines size, power consumption and cost.
Analysis and compensation of beat phenomenon for railway traction drive system fed with fluctuating DC-link voltage (2012)

The configuration of a single-phase AC-DC converter plus a three-phase DC-AC inverter traction system has been widely applied in high-speed railway electrical drive systems. The DC-link voltage contains a ripple component with a twice power line frequency because of the configuration of the single-phase converter. Fed by such a fluctuating DC-link voltage, a severe beat phenomenon of the motor current occurs, which causes torque ripple and a howling noise of the motor, especially when the electric frequency of the motor is in the neighborhood of the DC- link ripple frequency. The origin of DC-link voltage fluctuation and beat phenomena effect are analyzed in detail. For reducing the beat effect of DC-link voltage fluctuation without using an additional resonant filter at DC-link in the traction drive system, a beat-less control scheme based on the frequency modulation and vector control is discussed in detail. Simulation and hardware-in-the-loop (HIL) experimental results confirm the effectiveness and validity of the adopted scheme.
Genetic and Chemical Modifiers of a CUG Toxicity Model in Drosophila (2008)

Non-coding CUG repeat expansions interfere with the activity of human Muscleblind-like (MBNL) proteins contributing to myotonic dystrophy 1 (DM1). To understand this toxic RNA gain-of-function mechanism we developed a Drosophila model expressing 60 pure and 480 interrupted CUG repeats in the context of a non-translatable RNA. These flies reproduced aspects of the DM1 pathology, most notably nuclear accumulation of CUG transcripts, muscle degeneration, splicing misregulation, and diminished Muscleblind function in vivo. Reduced Muscleblind activity was evident from the sensitivity of CUG-induced phenotypes to a decrease in muscleblind genetic dosage and rescue by MBNL1 expression, and further supported by the co-localization of Muscleblind and CUG repeat RNA in ribonuclear foci. Targeted expression of CUG repeats to the developing eye and brain mushroom bodies was toxic leading to rough eyes and semilethality, respectively. These phenotypes were utilized to identify genetic and chemical modifiers of the CUG-induced toxicity. 15 genetic modifiers of the rough eye phenotype were isolated. These genes identify putative cellular processes unknown to be altered by CUG repeat RNA, and they include mRNA export factor Aly, apoptosis inhibitor Thread, chromatin remodelling factor Nurf-38, and extracellular matrix structural component Viking. Ten chemical compounds suppressed the semilethal phenotype. These compounds significantly improved viability of CUG expressing flies and included non-steroidal anti-inflammatory agents (ketoprofen), muscarinic, cholinergic and histamine receptor inhibitors (orphenadrine), and drugs that can affect sodium and calcium metabolism such as clenbuterol and spironolactone. These findings provide new insights into the DM1 phenotype, and suggest novel candidates for DM1 treatments.