gebhart/patrepeval huggingface dataset:
Efeito da atividade fisica aeróbica (natação) com suplementação sobre os tecidos musculares e cardiaco em ratos (2014)

The aim was to investigate the effect of aerobic physical activity (swimming) supplementation on skeletal and cardiac muscle tissues as well as the influence of supplementation to gain muscle mass by measuring body weight daily. We used male Wistar rats, approximately 60 days kept in individual cages in the vivarium it selffed with balanced feed and water, water for physical activity at room temperature, and charges for execution supplements. The rats were randomly divided into the following groups: G1 controle, G2 control+physical activity without load; G3 physical activity without load+maltodextrin; G4 physical activity without load+creatine G5 physical activity without load+creatine and maltodextrin; G6 control+physical activity load; G7 physical activity load+maltodextrin; G8 physical activity load+creatine; G9 physical activity load+creatine and maltodextrin; concluded that, in the administration of supplements to swimming, there were no significant results in relation to muscle mass, however, there significances for recovery physical strength. Despite these results, there is a need for further studies to prove the use of supplementation in humans.
Recently identified peptides involved in the regulation of body weight. (1998)

The application of molecular and genetic techniques to the study of body weight regulation have produced exciting new insights into the physiological systems governing energy expenditure, appetite, and metabolic signaling. A number of new peptides have been identified that play important roles in these regulatory systems. These include the hormone leptin, the short and long forms of the leptin receptor, uncoupling proteins, agouti protein, melanocortin receptor isoforms, melanin-concentrating hormone, and the proteins responsible for tub and fat, two monogenic mouse models of obesity. This article reviews some of the new insights gained from studies of these peptides. Although much of this new knowledge has come from studies of obesity, there may be implications for the clinical syndromes associated with weight loss. As more is learned about these systems, potential new targets for therapeutic intervention will likely become evident. These interventions may develop first as obesity treatments, but investigators and clinicians involved in the care of cachectic patients should follow these scientific developments as well.
Role of the Second Extracellular Loop of Human C3a Receptor in Agonist Binding and Receptor Function (1999)

The C3a anaphylatoxin receptor (C3aR) is a G protein-coupled receptor with an unusually large second extracellular loop (e2 loop, approximately 172 amino acids). To determine the function of this unique structure, chimeric and deletion mutants were prepared and analyzed in transfected RBL-2H3 cells. Whereas replacement of the C3aR N-terminal segment with that from the human C5a receptor had minimal effect on C3a binding, substitution of the e2 loop with a smaller e2 loop from the C5a receptor (C5aR) abolished binding of 125I-C3a and C3a-stimulated calcium mobilization. However, as much as 65% of the e2 loop sequence (amino acids 198-308) may be removed without affecting C3a binding or calcium responses. The e2 loop sequences adjacent to the transmembrane domains contain multiple aspartate residues and are found to play an important role in C3a binding based on deletion mutagenesis. Replacement of five aspartate residues in the e2 loop with lysyl residues significantly compromised both the binding and functional capabilities of the C3a receptor mediated by intact C3a or by two C3a analog peptides. These data suggest a two-site C3a-C3aR interaction model similar to that established for C5a/C5aR. The anionic residues near the N and C termini of the C3aR e2 loop constitute a non-effector secondary interaction site with cationic residues in the C-terminal helical region of C3a, whereas the C3a C-terminal sequence LGLAR engages the primary effector site in C3aR.
Inhibition of mitochondrial proton F0F1‐ATPase/ATP synthase by polyphenolic phytochemicals (2000)

Mitochondrial proton F0F1-ATPase/ATP synthase synthesizes ATP during oxidative phosphorylation. In this study, we examined the effects of several groups of polyphenolic phytochemicals on the activity of the enzyme. Resveratrol, a stilbene phytoalexin that is present in grapes and red wine, concentration-dependently inhibited the enzymatic activity of both rat brain and liver F0F1-ATPase/ATP synthase (IC(50) of 12 - 28 microM). Screening of other polyphenolic phytochemicals using rat brain F0F1-ATPase activity resulted in the following ranking potency (IC(50) in parenthesis): piceatannol (8 microM)>resveratrol (19 microM)=(-)epigallocatechin gallate (17 microM)>(-)epicatechin gallate, curcumin (45 microM)>genistein=biochanin A=quercetin=kaempferol=morin (55 - 65 microM)>phloretin=apigenin=daidzein (approx. 100 microM). Genistin, quercitrin, phloridzin, (+)catechin, (+)epicatechin, (-)epicatechin and (-)epigallocatechin had little effect at similar concentrations. Tannic acid, theaflavins (tea extract) and grape seed proanthocyanidin extract (GSPE) had IC(50) values of 5, 20 and 30 microg ml(-1), respectively. Several monophenolic antioxidants and non-phenolic compounds were ineffective at concentrations of 210 microM or higher. The inhibition of F0F1-ATPase by resveratrol and genistein was non-competitive in nature. The effects of polyphenolic phytochemicals were additive. Both resveratrol and genistein had little effect on the Na(+)/K(+)-ATPase activity of porcine cerebral cortex, whereas quercetin had similar inhibitory potency as for F0F1-ATPase. In conclusion, the ATP synthase is a target for dietary phytochemicals. This pharmacological property of these phytochemicals should be included in the examination of their health benefits as well as potential cytotoxicity.
Kerr effect in an optical passive ring-resonator gyro (1986)

The Kerr effect in an optical passive ring-resonator gyro (OPRG) is analyzed considering the optical source coherence. This effect causes the drift to be much greater than the theoretical limit of rotation sensing given by the detector shot noise for an OPRG with high sensitivity. The drift depends not only on the fluctuation of the power splitting ratio between two counter-propagating beams in the resonator, but also on the frequency modulation indices used to set the operating point. Square-wave intensity modulation of the incident beam is also discussed as a way to eliminate the drift. It is found that the ratio of the signal-beam round-trip time in the resonator to the modulation period must be an integer to optimize the drift elimination. From the practical viewpoint, the requirement for the modulation parameters is analyzed numerically.
Coplanar integrated mixers for 77-GHz automotive applications (1998)

For integration in receivers at 77 GHz, three passive mixers, a balanced diode mixer, a single ended and a balanced resistive mixer, as well as an active single-ended gate mixer have been realized in coplanar 0.15-μm PM-HEMT technology on GaAs. The passive mixers achieved conversion losses of about 9 dB. The resistive mixers required an LO power of only 3 dBm and the diode mixer 10 dBm for optimum conversion. The gate mixer obtained a conversion gain of 1 dB for an LO power of 6 dBm, but showed higher sensitivity to the IF load.
Thin Layer Chromatographic Analysis of Simple Alkyl Phenols. (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThin Layer Chromatographic Analysis of Simple Alkyl Phenols.G. B. CrumpCite this: Anal. Chem. 1964, 36, 13, 2447–2451Publication Date (Print):December 1, 1964Publication History Published online1 May 2002Published inissue 1 December 1964https://pubs.acs.org/doi/10.1021/ac60219a021https://doi.org/10.1021/ac60219a021research-articleACS PublicationsRequest reuse permissionsArticle Views90Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Investigation of Polycrystalline Nickel Silicide Films as a Gate Material (2001)

The work function of polycrystalline nickel silicide film formed by rapid thermal annealing (RTA) has been studied using capacitance-voltage (C-V) measurements and metal-oxide semiconductor (MOS) structures. The effect of sintering temperature on work function has also been studied. Results show that the work function of NiSi gate is about 4.6 eV and is stable from 400 to 800°C. For NiSi gate, the work function is 5 eV. The gate-substrate leakage current is small and the oxide quality is similar to that in Al-gate MOS capacitors even for oxides as thin as 8 nm. The poly-gate depletion effect (PDE) has also been investigated by quasi-static C-V. Compared with that of poly-Si and no PDE is observed in silicide-gate n-MOS device even when the gate is undoped. The results suggest that nickel silicide film may be used as a potential gate material in complementary MOS or thin-film transistor devices. © 2001 The Electrochemical Society. All rights reserved.
Data compression, generalisation and overgeneralisation in an evolving theory of language development (1980)

This paper describes a computer model of first language acquisition, program SNPR14, which is a development of an earlier model, MK10/GRAM15, described elsewhere [Wolff, 1978a and b]. Like the earlier model, SNPR14 shows some success in discovering a phrase-structure grammar from an unsegmented, semantics-free, language-like text given only that text as data. SNPR14 is designed to remedy certain weaknesses in MK10/GRAM15. In particular it provides a tentative answer to the problem of how it is that children, in forming syntactic generalisations, can distinguish correct generalisations from overgeneralisations and can eliminate the latter whilst retaining the former.

The notion that language development and data compression are intimately related has been extended here: it is suggested that language development is, in part, a process of building a grammar in such a way that the effectiveness of the grammar as a means of compressing cognitive data is maximised for any given size of grammar.
Schematic-Level and Layout-Level ESD EDA check methodology applied to smart power IC's - initialization and implementation (2015)

A functional methodology to fully check IC ESD network topology together with protected circuitry ESD compliance at Schematic-Level and metal interconnections at Layout-Level is developed and applied to Smart Power products. A common operational method is developed to simultaneously initialize different Schematic-Level and Layout-Level verification tools.
Validation of the NPI-Q, a Brief Clinical Form of the Neuropsychiatric Inventory (2000)

The Neuropsychiatric Inventory (NPI) is a validated clinical instrument for evaluating psychopathology in dementia. The authors developed a brief questionnaire form of the NPI (NPI-Q), intended for use in routine clinical practice, and cross-validated it with the NPI in 60 Alzheimer's patients. Test-retest reliability of the NPI-Q was acceptable. The prevalence of analogous symptoms reported on the NPI and NPI-Q differed on average by 5%; moderate or severe symptom ratings differed by less than 2%. The NPI-Q provides a brief, reliable, informant-based assessment of neuropsychiatric symptoms and associated caregiver distress that may be suitable for use in general clinical practice.
Mechanisms of rejection (2013)

Complement has evolved as the first line of defence against pathogens, employing well defined effector mechanisms to rapidly remove infectious material. However, complement effector mechanisms are also triggered during inflammation associated with solid organ transplantation. Hence, complement has a significant role in mediating donor organ injury during both the initial ischaemia/reperfusion phase and the subsequent adaptive immune responses. Research on mechanisms of complement-mediated injury in transplantation provide a basis for the development of therapies that are aimed at transiently blocking complement activation at the site of injury, whereas leaving systemic anti-bacterial complement effector mechanisms intact.
Stimulation of Toll-Like Receptor 9 by Chronic Intraventricular Unmethylated Cytosine-Guanine DNA Infusion Causes Neuroinflammation and Impaired Spatial Memory (2009)

Bacterial DNA contains a high frequency of unmethylated cytosine-guanine (CpG) motifs that have strong immunostimulatory properties; they are recognized by mammalian Toll-like receptor 9 (TLR9). Because accumulating data suggest that chronic inflammatory processes are involved in the pathogenesis of neurodegenerative diseases, we hypothesized that inflammatory responses stimulated by CpG DNA might contribute to neurodegeneration and brain dysfunction. To assess the effects of continuous CpG DNA exposure in the brain, C57BL/6 (n = 21) and TLR9-deficient mice (n = 15) were given intracerebroventricular infusions of CpG DNA or saline for 28 days. Spatial memory assessed weekly by Morris water maze demonstrated impairment in CpG-treated wild-type mice but not in TLR9-deficient or control-treated mice. Motor function was not affected. Immunohistochemical analysis revealed marked microglial activation and acute axonal damage surrounding the ventricles, ependymal disruption, and reactive astrogliosis within the hippocampal formation in the CpG-treated wild-type but not TLR9-deficient mice or saline-infused controls. These results suggest that the unfavorable effects of CpG DNA are dependent on TLR9 signaling and that exposure to bacterial DNA may contribute to impaired neural function, neuroinflammation, and subsequent neurodegeneration.
The Cysteine Residue Responsible for the Release of Fibroblast Growth Factor-1 Resides in a Domain Independent of the Domain for Phosphatidylserine Binding (1995)

Fibroblast growth factor (FGF)-1 lacks a classical signal sequence to direct its secretion yet utilizes high affinity cell surface receptors to signal its heparin-dependent angiogenic and neurotrophic activities. We have previously reported that FGF-1 is released in response to temperature stress as a latent homodimer through a pathway that is potentiated by the Golgi inhibitor, brefeldin A (Jackson, A., Tarantini, F., Gamble, S., Friedman, S., and Maciag, T. (1995) J. Biol. Chem. 270, 33-36). In an attempt to further characterize this unconventional secretion mechanism, we sought to define the Cys residue(s) critical for FGF-1 dimer formation and release and to determine whether FGF-1 can associate with known phospholipid components of organelle or plasma membranes, which may be disturbed by brefeldin A. Utilizing FGF-1 Cys mutants, we were able to demonstrate that residue Cys30 is critical for FGF-1 release in response to heat shock. In addition, using solid phase phospholipid binding assays we demonstrate that FGF-1 is able to specifically associate with phosphatidylserine (PS). Heparin inhibits the association between FGF-1 and PS, and synthetic peptide competition assays suggest that the PS-binding domain of FGF-1 lies between residues 114 and 137. These observations indicate that FGF-1 may be able to associate with the PS component of organelle and/or plasma membranes and that the domains responsible for FGF-1 homodimer formation and PS binding are structurally distinct.
A Mathematical Description of Layered Manufacturing Fabrication (1999)

This study is attempted to use a mathematical definition to describe the principles of Layer Manufacturing Processing. The concept of model decoll1Position (layered subtraction for 3D model slicing) and material accumulation (layered addition for
The Role of Competing Demands in the Treatment Provided Primary Care Patients With Major Depression (2000)

The attention depression gets during a given medical visit is less associated with the severity of the patient's depressive symptoms than with the number or recency of other problems the patient has. If competing demands provide ongoing barriers to depression treatment, interventions will be needed to assure that patients with chronic physical problems receive high-quality mental health care in the primary care setting.
Tolerable Hearing Aid Delays. V. Estimation of Limits for Open Canal Fittings (2008)

A disturbance rating of 3 may be considered as just acceptable. This rating was reached for delays of about 5 and 6 msec, for simulated hearing losses starting at 2 and 1 kHz, respectively. The perceptual effect of reducing the spectral ripples produced by comb-filtering was small; the effect was greatest when the hearing aid gain was small and when the hearing loss started at a low frequency.
Converting printed Sinhala documents to formatted editable text (2010)

Digitizing printed document is always a challenge faced by the computing society. Digitization of text not only allows users to easily modify and reprint printed documents, but also is a need of the day due to the use of word-search capability available at disposal in this era. Converting a printed document into a stream of characters using OCR (optical character recognition) techniques is a widely researched area of the past and there are a number of well established algorithms available in the literature to do so. However, the idea of preserving the formatting information of the original document is not much studied. The contribution of this paper is of two folds: (1) applying known OCR techniques to one of Sri Lanka's native languages, Sinhala, and addressing the challenges in doing so and (2) maintaining a number of selected formatting features of the printed document in the converted editable text. Therefore, this paper outlines the design and implementation of a software system that converts a scanned paper document written in Sinhala language into formatted editable text and describes how this system is integrated into an open-source word processing tool.
Phosphorylation of Tomato 1-Aminocyclopropane-1-carboxylic Acid Synthase, LE-ACS2, at the C-terminal Region (2001)

1-aminocyclopropane-1-carboxylic acid synthase is a key enzyme in the ethylene biosynthesis pathway. Recent studies raise the possibility that 1-aminocyclopropane-1-carboxylic acid synthase (ACS) is regulated not only transcriptionally but also post-translationally. To elucidate post-translational ACS regulation, we analyzed the modification of LE-ACS2 protein, a wound-inducible isozyme in the ACS family, in tomato fruit (Lycopersicon esculentum L.) using an anti-LE-ACS2 antibody. We detected phosphorylated LE-ACS2 at 55-kDa using immunoprecipitation from an extract of wounded fruit fed with [32P]inorganic phosphate. Analysis of LE-ACS2 phosphoamino acids indicated that serine residue(s) were phosphorylated. In vitro phosphorylation analyses using site-directed mutagenesis of recombinant LE-ACS2 as a substrate demonstrate that serine 460 located at the C-terminal region of ACS is phosphorylated. During tomato ripening stages, expression of both LE-ACS2 and LE-ACS4 mRNA increased. LE-ACS4, however, was not phosphorylated in vitro. These results suggest that ACS isozymes have different post-translational regulatory mechanisms, such as phosphorylation.
Enabling Sparse Winograd Convolution by Native Pruning (2017)

Sparse methods and the use of Winograd convolutions are two orthogonal approaches, each of which significantly accelerates convolution computations in modern CNNs. Sparse Winograd merges these two and thus has the potential to offer a combined performance benefit. Nevertheless, training convolution layers so that the resulting Winograd kernels are sparse has not hitherto been very successful. By introducing a Winograd layer in place of a standard convolution layer, we can learn and prune Winograd coefficients "natively" and obtain sparsity level beyond 90% with only 0.1% accuracy loss with AlexNet on ImageNet dataset. Furthermore, we present a sparse Winograd convolution algorithm and implementation that exploits the sparsity, achieving up to 31.7 effective TFLOP/s in 32-bit precision on a latest Intel Xeon CPU, which corresponds to a 5.4x speedup over a state-of-the-art dense convolution implementation.
Nonstoichiometric Perovskite CaMnO<sub>3−δ</sub> for Oxygen Electrocatalysis with High Activity (2014)

Perovskite oxides offer efficient and cheap electrocatalysts for both oxygen reduction reactions and oxygen evolution reactions (ORR/OER) in diverse oxygen-based electrochemical technologies. In this study, we report a facile strategy to enhance the electrocatalytic activity of CaMnO3 by introducing oxygen defects. The nonstoichiometric CaMnO(3-δ) (0 < δ ≤ 0.5) was prepared through thermal reduction of pristine perovskite microspheres and nanoparticles, which were synthesized from thermal-decomposition of carbonate precursors and the Pechini route, respectively. The as-prepared samples were analyzed by chemical titration, structural refinement, thermogravimetric analysis, and energy spectrometry. In 0.1 M KOH aqueous solution, the nonstoichiometric CaMnO(3-δ) with δ near 0.25 and an average Mn valence close to 3.5 exhibited the highest ORR activity (36.7 A g(-1) at 0.70 V vs RHE, with onset potential of 0.96 V), which is comparable to that of benchmark Pt/C. Density functional theory (DFT) studies and electrical conductivity measurement revealed that the enhanced ORR kinetics is due to facilitated oxygen activation and improved electrical properties. Besides high activity, the nonstoichiometric perovskite oxides showed respectable catalytic stability. Furthermore, the moderate oxygen-defective CaMnO(3-δ) (δ ≈ 0.25) favored the OER because of the improved electrical conductivity. This study makes nonstoichiometric CaMnO(3-δ) a promising active, inexpensive bifunctional catalytic material for reversible ORR and OER.
Ir-Catalyzed Preparation of SF<sub>5</sub>-Substituted Potassium Aryl Trifluoroborates via C–H Borylation and Their Application in the Suzuki–Miyaura Reaction (2013)

The preparation of new pentafluorosulfanyl-substituted potassium aryltrifluoroborates via Ir-catalyzed C-H borylation is reported. The utility of these novel building blocks was demonstrated in the Suzuki-Miyaura cross-coupling reaction, giving access to 3,5-disubstituted pentafluorosulfanylbenzenes.