gebhart/patrepeval huggingface dataset:
Regeneration of the basal lamina complex during epithelial wound healing (1977)

The purpose of this study was to follow the time sequence of events in the reformation of the attachment complex between epithelium and lamina propria of oral mucosa following incisional wounding. An incisional wound of minimal depth was made along the dorsal surface of rat tongue. From nine groups of animals, tissue specimens were collected from 0 through 96 hours and processed routinely for electron microscopy. The formation of the attachment complex was followed in relation to the epithelial cells migrating across the wound space. The earliest discernable changes denoting initiation of reattachment were preceded by a short period of direct contact between epithelial plasma membrane and fibrin. Attachment did not occur in epithelial cells not bordering on fibrin, suggesting that in the system studied such contact is a prerequisite for reattachment. The ultrastructural components of the attachment complex appeared in an orderly chronologic and spatial sequence, with the additional components appearing as time elapsed between the arrival of the cell in its new location and the collection of the tissue specimen.
A straightforward route to electron transporting conjugated polymers (2012)

We report a straightforward synthetic method to generate solution processable electron transporting polymers with low band gap and wide absorption range from readily available acceptor monomers. We show the efficacy of this approach using widely used electron acceptor 2,1,3-benzothiadiazole. The polymers have absorption up to 750 nm with electron mobility comparable to PCBM.
Building the Road Map for a Performance-Driven Organization (1999)

The strategic importance of performance improvement (PI) in healthcare is being recognized across the country. Organizations that recognize PI's importance and support PI will be better prepared for a healthcare future that mandates measurable value. Building the foundation for success is neither a simple task nor a cheap one. It requires a total systems perspective on improving processes and systems, a commitment to continual learning, and recognition of what other industries have already learned--to succeed, you must constantly innovate and improve. This article discusses one organization's approach to building the foundation for a performance-driven 21st-century healthcare system.
Microvalve-actuated precise control of individual droplets in microfluidic devices (2009)

Integrated microvalves have been used to precisely and flexibly control the generation, size, composition of individual droplets and fusion of different droplets in microfluidic devices.
Incoherent combining of 100-W Yb-fiber laser beams by PTR Bragg grating (2003)

Volume diffractive gratings (Bragg gratings) in photo-thermo-refractive (PTR) inorganic glass are proposed for incoherent laser beam combining because they have narrow spectral selectivity and diffraction efficiency greater than 95% from visible to near IR regions. They showed no laser-induced damage, no thermal lens, and no Bragg angle shift under CW Yb-fiber laser (1096 nm) irradiation at 100 kW/cm<sup>2</sup>. It opens the way to rugged, low-cost, efficient optics for high-power laser systems. Based on theoretical modeling of PTR Bragg gratings, we have designed a high-efficient technology for incoherent combining of two or several laser beams with certain wavelength shift. Two 100 W beams of Yb-fiber lasers in the range of 1080-1100 nm with the wavelength separation of 11 nm were combined with efficiency exceeding 75% while material losses did not exceed 2-4%. No fading or parameter change of PTR Bragg grating working in two 100 W beams were found. It was found that the process limiting efficiency of incoherent beam combining is the spectral widening of radiation of Yb-doped fiber lasers. At high power, their spectral width exceeds spectral selectivity of Bragg grating and causes a decrease of diffraction efficiency.
Impaired lipopolysaccharide-inducible tumor necrosis factor production in vitro by peripheral blood monocytes of patients with viral hepatitis (1990)

We investigated lipopolysaccharide-induced tumor necrosis factor production in vitro by peripheral blood monocytes from patients with various liver diseases. Tumor necrosis factor production was found to be significantly reduced in patients with chronic hepatitis B (n = 17; 135 +/- 30 pg tumor necrosis factor/ml; mean +/- S.E.M.) and patients with chronic non-A, non-B hepatitis (n = 15; 212 +/- 22 pg tumor necrosis factor/ml) compared with healthy control individuals (n = 47; 411 +/- 40 pg tumor necrosis factor/ml; p less than 0.0005 and p less than 0.01, respectively). This reduced tumor necrosis factor production was not only seen with an optimal stimulating concentration of lipopolysaccharide (100 ng/ml) but also with suboptimal concentrations (0.1 ng/ml). In contrast to patients with chronic viral hepatitis, monocytes from patients with alcohol-induced cirrhosis (n = 26; 444 +/- 49 pg tumor necrosis factor/ml), primary biliary cirrhosis (n = 7; 412 +/- 81 pg tumor necrosis factor/ml) and alcohol-induced fatty liver changes (n = 5; 401 +/- 62 pg tumor necrosis factor/ml) produced normal amounts of tumor necrosis factor when stimulated with an optimal concentration of lipopolysaccharide. Lipopolysaccharide (0.1 ng lipopolysaccharide/ml)-stimulated peripheral blood monocytes of patients with chronic hepatitis B (n = 15; 102 +/- 32 pg/ml) or non-A, non-B hepatitis (n = 13; 97+/- 16 pg/ml) could not be induced to produce more tumor necrosis factor either when prestimulated with gamma-interferon (170 +/- 45 pg/ml and 149 +/- 32 pg/ml, respectively), a lymphokine known to activate monocytes, or with the cyclooxygenase inhibitor indomethacin to reduce the suppressive effect of prostaglandin E2 (148 +/- 40 pg/ml and 153 +/- 45 pg/ml, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
Increased levels of a humoral digitalis-like factor in deoxycorticosterone acetate-induced hypertension in the pig (1989)

Plasma levels of an endogenous digitalis-like factor (EDLF) and atrial peptides were followed in pigs confined to metabolic cages during the development of deoxycorticosterone acetate (DOCA)-induced hypertension. During the first 2 days of DOCA treatment, urinary sodium excretion decreased and the plasma levels of renin and atrial peptide fell significantly. During this period, plasma levels of EDLF increased greater than 30-fold from a baseline of less than 0.25 to 9.72 nmol ouabain equivalents/l. Between days 2 and 5 of DOCA treatment, urinary sodium returned to pre-DOCA levels ('mineralocorticoid escape') and during this period significant increases of atrial peptide and mean arterial pressure (MAP) and a decrease in EDLF were found. Following mineralocorticoid escape there was a secondary rise in levels of EDLF and atrial peptide and both phenomena correlated with MAP (EDLF, r = 0.87, P less than 0.05; atrial peptide, r = 0.9, P less than 0.05) and with each other (r = 0.96, P less than 0.05) over a 20-day period. Acute expansion of extracellular fluid volume before DOCA elicited significant increments in plasma EDLF and atrial peptide. Volume loading during chronic DOCA treatment increased plasma EDLF significantly whereas no response of atrial peptide was detected. These results suggest that DOCA affects the reactivity of mechanisms involved in the perception of and/or response to acute changes in volume status. However, neither EDLF nor atrial peptide appear to be viable candidates as direct mediators of mineralocorticoid escape. Finally, the nature of the changes found in EDLF and atrial peptide levels during DOCA treatment suggest that these factors are involved in the long-term control of blood pressure in this model of low renin hypertension.
Relation between Protein Intake, Plasma Valine, and Insulin Secretion during Early Infancy* (1985)

During the first 6 months of life the plasma levels of branch-chained amino acids are related to the amount of protein ingested. Thus, the concentrations are lower in breast-fed infants than in artificially fed infants who are on a formula with a protein content which is about 50 per cent higher than in breast milk. At 3, 4 1/2, and 6 months of age the concentrations of valine in plasma and C-peptide in urine and the ratio between C-peptide and creatinine in urine are 2-3 times higher in artificially fed than in breast-fed infants. Plasma valine values correlate significantly with the urinary C-peptide/creatinine ratio. The enhanced insulin response induced by a cow's milk formula is related to the protein content.
An Optimized Strategy for Genome Assembly of Sanger/pyrosequencing Hybrid Data using Available Software (2008)

During the last four years, the pyrosequencing-based 454 platform has rapidly displaced the traditional Sanger sequencing method due to its high throughput and cost effectiveness. Meanwhile, the Sanger sequencing methodology still provides the longest reads, and paired-end sequencing that is based on that chemistry offers an opportunity to ensure accurate assembly results. In this report, we describe an optimized approach for hybrid de novo genome assembly using pyrosequencing data and varying amounts of Sanger-type reads. 454 platformderived contigs can be used as single non-breakable virtual reads or converted to simpler contigs that consist of editable, overlapping pseudoreads. These modified contigs maintain their integrity at the first jumpstarting assembly stage and are edited by fragmenting and rejoining. Pre-existing assembly software then can be applied for mixed assembly with 454-derived data and Sanger reads. An effective method for identifying genomic differences between reference and sample sequences in whole-genome resequencing procedures also is suggested.
Using Fragment Cocktail Crystallography To Assist Inhibitor Design of <i>Trypanosoma brucei </i>Nucleoside 2-Deoxyribosyltransferase (2006)

The 1.8 A resolution de novo structure of nucleoside 2-deoxyribosyltransferase (EC 2.4.2.6) from Trypanosoma brucei (TbNDRT) has been determined by SADa phasing in an unliganded state and several ligand-bound states. This enzyme is important in the salvage pathway of nucleoside recycling. To identify novel lead compounds, we exploited "fragment cocktail soaks". Out of 304 compounds tried in 31 cocktails, four compounds could be identified crystallographically in the active site. In addition, we demonstrated that very short soaks of approximately 10 s are sufficient even for rather hydrophobic ligands to bind in the active site groove, which is promising for the application of similar soaking experiments to less robust crystals of other proteins.
Using Software in Teaching of English as a Foreign Language (2005)

Computer Assisted Language Learning (CALL) is playing a more important role in Teaching of English as a Foreign Language (TEFL). Teachers of English classroom need to discover more benefits from the computer as an assisting tool. This paper first deals with the roles of the computer, and then expatiates on the benefits software can bring to both English teachers and learners. This paper also suggests some tasks designed upon software and attempts to serve as a little drop which can make a shower on a further study on CALL.
Formation of Composite Endothelial Cell–Mesenchymal Stem Cell Islets (2008)

EC proliferation, sprout formation, and ingrowth of ECs into the islets were enhanced by MSCs. The use of composite EC-MSC islets may have beneficial effects on revascularization and immune regulation. The technique presented allows for pretreatment of donor islets with recipient-derived ECs and MSCs as a means of improving islet engraftment.
An Algorithm for Constructing Hypothetical Evolutionary Trees Using Common Mutation Similarity Matrices (2013)

In this paper, we introduce a new evolutionary tree algorithm that is based on common mutation similarity matrices instead of distance matrices.
An electrical optimizer that considers physical layout (1988)

Electrical performance and area improvement are important parts of the overall VLSI design task. Given designer specified constraints on area, delay, and power, EPOXY will size a circuit's transistors and will attempt small circuit changes to help meet the constraints. In addition, the system provides a flexible framework within which to evaluate the effects of different area and electrical models, as well as different optimization algorithms. Since the sum of transistor area is a better measure of dynamic power than cell area, a more accurate area model is presented. Optimization of a CMOS eight-stage inverter chain illustrates this difference; a typical minimum power implementation is 32.3% larger than the one for minimum area. The combination of a TILOS-style heuristic and augmented Lagrangian optimization algorithm yields quality results rapidly. EPOXY'S circuit analysis is from 5 to 56 times faster than Crystal.
Structure and Hepatoprotective Activity of a Biflavonoid from<i>Canarium manii</i> (1992)

Canarium manii (Burseraceae) was chemically investigated and the presence of the biflavonoid agathisflavone is reported for the first time from this plant. Pharmacologically, this biflavonoid in doses 50.0 mg and 100.0 mg given orally exhibited dose-dependent hepatoprotective activity against experimentally-induced carbon tetrachloride-hepatotoxicity in rats and mice.
Highly Stable Transparent Conductive Silver Grid/PEDOT:PSS Electrodes for Integrated Bifunctional Flexible Electrochromic Supercapacitors (2015)

Silver grids are attractive for replacing indium tin oxide as flexible transparent conductors. This work aims to improve the electrochemical stability of silver‐based transparent conductors. A silver grid/PEDOT:PSS hybrid film with high conductivity and excellent stability is successfully fabricated. Its functionality for flexible electrochromic applications is demonstrated by coating one layer of WO 3 nanoparticles on the silver grid/PEDOT:PSS hybrid film. This hybrid structure presents a large optical modulation of 81.9% at 633 nm, fast switching, and high coloration efficiency (124.5 cm 2 C −1 ). More importantly, an excellent electrochemical cycling stability (sustaining 79.1% of their initial transmittance modulation after 1000 cycles) and remarkable mechanical flexibility (optical modulation decay of only 7.5% after 1200 compressive bending cycles) is achieved. A novel smart supercapacitor is presented that functions as a regular energy‐storage device and simultaneously monitors the level of stored energy by a rapid and reversible color variation even at high current charge/discharge conditions. The film sustains an optical modulation of 87.7% and a specific capacitance of 67.2% at 10 A g −1 compared to their initial value at a current density of 1 A g −1 . The high‐performance silver grid/PEDOT:PSS hybrid transparent films exhibit promising features for various emerging flexible electronics and optoelectronic devices.
Chaotic real-time encryption using systems of difference equations with large parameter spaces (2002)

We present a new class of discrete chaotic systems (i.e. chaotic maps) that can effectively encrypt information. The nonlinearity of these systems is achieved by designing proper piecewise linear functions and by using modulo operations. The chaotic maps are used as pseudo-noise generators and as the synchronization mechanism of a secure spread-spectrum communication system design. The potential for automatic synchronization, the lack of periodicity and the extremely large parameter spaces that our chaotic maps exhibit offer great advantages over the traditional linear feedback shift registers pseudo-noise generators for spread spectrum system design.
Linearity improvement of high-speed avalanche photodiodes using thin depleted absorber operating with higher order modulation format (2015)

We present an avalanche photodiode (APD) with high-speed, high-responsivity and high-linearity operation to cope with higher order modulation format, such as pulse-amplitude modulation (PAM). A hybrid absorber configuration with thin depleted region which we newly employed successfully eliminates the space charge effect in the APD while maintaining high responsivity and operating speed. The fabricated APD shows an improved optical-input-electrical-output linearity for an optical input power over -8 dBm, and an optical receiver with this APD achieves both an error-free operation with a KP4 FEC and a high sensitivity of -17 dBm against a 28-Gbaud PAM4 signal.
[Lipid derivatives of sarcolysin, methotrexate and rubomycin]. (1996)

To change the pharmacokinetic properties of the known antitumor agents sarcolysine, rubomycin, and methotrexate, their lipid derivatives were synthesized with the residues of rac-1,2-dioleoylglycerol and heptadecyl alcohol. An ether lipid analog, 3-sarcolysyl 2-methyl-1-octadecyl-sn-glycerol, with the lipid moiety being itself an antineoplastic agent was also obtained.
Transient sorption of water vapor from air flowing through beds of zeolite 13X (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTransient sorption of water vapor from air flowing through beds of zeolite 13XDaryl R. Haefner and George ThodosCite this: Ind. Eng. Chem. Fundamen. 1986, 25, 4, 498–503Publication Date (Print):November 1, 1986Publication History Published online1 May 2002Published inissue 1 November 1986https://pubs.acs.org/doi/10.1021/i100024a007https://doi.org/10.1021/i100024a007research-articleACS PublicationsRequest reuse permissionsArticle Views188Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Development of half-metallic ultrathin Fe3O4 films for spin-transport devices (2002)

We attempted to fabricate a high-quality Fe3O4 film while satisfying both low-thermal preparation (≦573 K) and film thinness (≦500 Å). X-ray diffractometry showed that our prepared Fe3O4 film was epitaxially grown onto a MgO (100) substrate. The saturation magnetization, resistivity, and Verwey point were, respectively, ∼438 emu/cm3, ∼10 000 μ Ω cm, and ∼110 K. These values were comparable to those of the Fe3O4 bulk. Our experimental results suggested that a high-quality Fe3O4 film could be obtained even under the crucial conditions of the deposition temperature being low (∼523 K) and the film being ultrathinned (∼100 Å).
Depletion-Layer Photoeffects in Semiconductors (1959)

The theory of photoconduction through the reverse-biased $p\ensuremath{-}n$ junction in semiconductors is developed without the customary assumption that carrier generation in the junction depletion layer is negligible. Different from previous theories, the more general treatment leads to a voltage dependence of the photocurrent and its spectral distribution. When the incident light beam is modulated at frequencies comparable to the transit time through the depletion layer, a phase shift between the photon flux and photocurrent is noticed and transit-time rectification occurs.
In Active Relapsing-Remitting Multiple Sclerosis, Effector T Cell Resistance to Adaptive T <sub>regs</sub> Involves IL-6–Mediated Signaling (2013)

Patients with multiple sclerosis (MS) manifest demyelination and neurodegeneration mediated in part by CD4(+) T cells that have escaped regulation. Resistance of pathogenic effector T cells (T(effs)) to suppression by regulatory T cells (T(regs)) has been demonstrated in several autoimmune diseases. Although impairment in T(reg) number and function has been observed in relapsing-remitting MS (RRMS), T(eff) resistance has not been well studied in this disease. To determine whether T(eff) resistance contributes to failed tolerance in RRMS, we performed T(reg) suppression assays with T(effs) from either RRMS patients not on immunomodulatory therapy or healthy individuals. T(eff) resistance was present in the T(effs) of RRMS patients with active disease but not from patients with inactive disease. Interleukin-6 (IL-6) and phosphorylation of signal transducer and activator of transcription 3 (pSTAT3) promote T(eff) resistance to T(regs), and we found an increase in IL-6 receptor α (IL-6Rα) expression and elevated IL-6 signaling as measured by pSTAT3 in our RRMS subjects. Further, the impaired suppression in RRMS subjects correlated with an increase in IL-6Rα surface expression on CD4(+) T cells and an increase in pSTAT3 in response to IL-6. To address whether the enhanced pSTAT3 contributed to T(eff) resistance in active RRMS patients, we blocked STAT3 phosphorylation and found that impaired suppression was reversed. Therefore, enhanced IL-6R signaling through pSTAT3, in some cases through increased IL-6Rα expression, contributed to T(eff) resistance in active RRMS. These markers may aid in determining disease activity and responsiveness to immunomodulatory therapies in RRMS.
Efficient built-in self-repair strategy for embedded SRAM with selectable redundancy (2012)

Built-In Self-Repair (BISR) with Redundancy is an effective yield-enhancement strategy for embedded memories. This paper proposes an efficient BISR strategy which consists of a Built-In Self-Test (BIST) module, a Built-In Address-Analysis (BIAA) module and a Multiplexer (MUX) module. The BISR is designed flexible that it can provide four operation modes to SRAM users. Each fault address can be saved only once is the feature of the proposed BISR strategy. In BIAA module, fault addresses and redundant ones form a one-to-one mapping to achieve a high repair speed. Besides, instead of adding spare words, rows, columns or blocks in the SRAMs, users can select normal words as redundancy. The selectable redundancy brings no penalty of area and complexity and is suitable for compiler design. A practical 4K × 32 SRAM IP with BISR circuitry is designed and implemented based on a 55nm CMOS process. Experimental results show that the BISR occupies 20% area and can work at up to 150MHz.