gebhart/patrepeval huggingface dataset:
Electroreduction of carbon monoxide to methane and ethylene at a copper electrode in aqueous solutions at ambient temperature and pressure (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectroreduction of carbon monoxide to methane and ethylene at a copper electrode in aqueous solutions at ambient temperature and pressureYoshio Hori, Akira Murata, Ryutaro Takahashi, and Shin SuzukiCite this: J. Am. Chem. Soc. 1987, 109, 16, 5022–5023Publication Date (Print):August 1, 1987Publication History Published online1 May 2002Published inissue 1 August 1987https://doi.org/10.1021/ja00250a044RIGHTS & PERMISSIONSArticle Views2526Altmetric-Citations274LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (280 KB) Get e-Alertsclose Get e-Alerts
MoCHA: Augmenting pervasive displays through mobile devices and web-based technologies (2014)

In this article, we propose a web-based system, called MoCHA display, for rich interactions between pervasive displays and users with a mobile device. Our scheme consists of a web-centric architecture, in which both the screen and the mobile device simply need to run a web browser. Our contributions are twofold. First, we develop a distributed architecture based on modern web technologies and cloud computing to provide rich interactions between users equipped with a mobile device and pervasive screens. Second, we devise a mechanism for practical and secure binding of screens and mobile devices based on their proximity. We present a prototype of the system as well as some preliminary results about its usability and performance.
ChemInform Abstract: Direct Preparation of Arylmanganese Bromides Using Active Manganese. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
No human protein is exempt from bacterial motifs, not even one (2010)

The hypothesis that mimicry between a self and a microbial peptide antigen is strictly related to autoimmune pathology remains a debated concept in autoimmunity research. Clear evidence for a causal link between molecular mimicry and autoimmunity is still lacking. In recent studies we have demonstrated that viruses and bacteria share amino acid sequences with the human proteome at such a high extent that the molecular mimicry hypothesis becomes questionable as a causal factor in autoimmunity. Expanding upon our analysis, here we detail the bacterial peptide overlapping to the human proteome at the penta-, hexa-, hepta- and octapeptide levels by exact peptide matching analysis and demonstrate that there does not exist a single human protein that does not harbor a bacterial pentapeptide or hexapeptide motif. This finding suggests that molecular mimicry between a self and a microbial peptide antigen cannot be assumed as a basis for autoimmune pathologies. Moreover, the data are discussed in relation to the microbial immune escape phenomenon and the possible vaccine-related autoimmune effects.
‘Iron‐saturated’ lactoferrin is a potent natural adjuvant for augmenting cancer chemotherapy (2008)

Bovine lactoferrin (bLf), an iron-containing natural defence protein found in bodily secretions, has been reported to inhibit carcinogenesis and the growth of tumours. Here, we investigated whether natural bLf and iron-saturated forms of bLf differ in their ability to augment cancer chemotherapy. bLf was supplemented into the diet of C57BL/6 mice that were subsequently challenged subcutaneously with tumour cells, and treated by chemotherapy. Chemotherapy eradicated large (0.6 cm diameter) EL-4 lymphomas in mice that had been fed iron-saturated bLf (here designated Lf(+)) for 6 weeks prior to chemotherapy, but surprisingly not in mice that were fed lesser iron-saturated forms of bLf, including apo-bLf (4% iron saturated), natural bLf (approximately 15% iron saturated) and 50% iron-saturated bLf. Lf(+)-fed mice bearing either EL-4, Lewis lung carcinoma or B16 melanoma tumours completely rejected their tumours within 3 weeks following a single injection of either paclitaxel, doxorubicin, epirubicin or fluorouracil, whereas mice fed the control diet were resistant to chemotherapy. Lf(+) had to be fed to mice for more than 2 weeks prior to chemotherapy to be wholly effective in eradicating tumours from all mice, suggesting that it acts as a competence factor. It significantly reduced tumour vascularity and blood flow, and increased antitumour cytotoxicity, tumour apoptosis and the infiltration of tumours by leukocytes. Lf(+) bound to the intestinal epithelium and was preferentially taken up within Peyer's patches. It increased the production of Th1 and Th2 cytokines within the intestine and tumour, including TNF, IFN-gamma, as well as nitric oxide that have been reported to sensitize tumours to chemotherapy. Importantly, it restored both red and white peripheral blood cell numbers depleted by chemotherapy, potentially fortifying the mice against cancer. In summary, bLf is a potent natural adjuvant and fortifying agent for augmenting cancer chemotherapy, but needs to be saturated with iron to be effective.
Radical Copolymerization of a Phosphaalkene with Styrene: New Phosphine‐Containing Macromolecules and Their Use in Polymer‐Supported Catalysis (2004)

PC bonds mimic CC bonds in the radical-initiated copolymerization of a phosphaalkene 1 and styrene (see scheme). The resulting copolymers 2 have unprecedented phosphine-containing backbones with phosphorus compositions that vary depending on the monomer ratios. These novel functional hybrid inorganic–organic macromolecules are used as polymeric supports for the Pd-catalyzed Suzuki coupling. VAZO=1,1′-azobis(cyclohexanecarbonitrile).
A high gain lateral BJT on thin film silicon substrate (2009)

In this paper, a symmetric dual-emitter LBJT (SDE LBJT) structure on TFSOI substrates has been designed and simulated, and suitable doping profiles are used for improving LBJT performance. Simulations show that the device has good DC characteristics. The SDE LBJT with a base length of 0.2µm can achieve a current gain over 1500, which is 7.5 times improvement in current gain, in comparison to the LBJT reported previously. Also has good current drive and high frequency capability. These results indicate that the SDE LBJT structure is suitable for many low power mixed mode applications.
Using Crosshole Electromagnetics (EM) for Reservoir Characterization and Waterflood Monitoring (2000)

Abstract The crosshole EM technique provides an image analogous to a smoothed two-dimensional induction resistivity log. Inductive EM sources are placed in one well and magnetic field receivers in a second well, up to a km away. Sources and receivers are positioned above within and below the depth interval of interest, and we image the resistivity of the interwell volume to fit the collected data. Data may be collected in open and/or steel-cased boreholes, although steel casing reduces this range. The resolution of images is roughly 5 percent of the well spacing. The technique has been used for more than 5 years in imaging thermal oil recovery operations, but more recently for reservoir characterization and water flood imaging. The resistivity contrast between salt water saturated zones and oil and gas pay zones usually provides an excellent signal for the EM data and makes the imaging of the water flood fairly straightforward. In this paper we provide a technology overview and then show a case history where the EM resistivity images have defined the initial water saturation distribution, and have tracked changes over a two year period due to water flooding in a fracture dominated southern California reservoir. We further describe simulations for crosshole EM imaging in carbonates for a WAG (water alternating gas) process where the technique is used for initial site characterization and to monitor saturation changes during the injection.
Role of insulin in antigen-induced airway eosinophilia and neuronal M<sub>2</sub>muscarinic receptor dysfunction (1998)

In the lungs, neuronal M2 muscarinic receptors limit ACh release from parasympathetic nerves. In antigen-challenged animals, eosinophil proteins block these receptors, resulting in increased ACh release and vagally mediated hyperresponsiveness. In contrast, diabetic rats are hyporesponsive and have increased M2 receptor function. Because there is a low incidence of asthma among diabetic patients, we investigated whether diabetes protects neuronal M2 receptor function in antigen-challenged rats. Antigen challenge of sensitized rats decreased M2 receptor function, increased vagally mediated hyperreactivity by 75%, and caused a 10-fold increase in eosinophil accumulation around airway nerves. In antigen-challenged diabetic rats, neuronal M2 receptor function was preserved and there was no eosinophil accumulation around airway nerves. Insulin treatment of diabetic rats completely restored loss of M2 receptor function, vagally mediated hyperresponsiveness, and eosinophilia after antigen challenge. These data demonstrate that insulin is required for development of airway inflammation, loss of neuronal M2 muscarinic receptor function, and subsequent hyperresponsiveness in antigen-challenged rats and may explain decreased incidence of asthma among diabetic humans.
Comparison of lactate and bicarbonate buffered haemofiltration fluids: use in critically ill patients (1997)

The degree of correction of acidosis during the first 24 h of haemofiltration was determined by patients outcome but was not affected by the substitution of bicarbonate- for lactate-containing replacement fluids.
Whole-Blastocyst Culture Followed by Laser Drilling Technology Enhances the Efficiency of ICM Isolation and ESC Derivation from Good- and Poor-Quality Mouse Embryos: New Insights for Derivation of hESC Lines (2008)

The optimization of human embryonic stem (hES) cell line derivation methods is challenging because many worldwide laboratories have neither access to spare human embryos nor ethical approval for using supernumerary human embryos for hES cell derivation purposes. Additionally, studies performed directly on human embryos imply a waste of precious human biological material. In this study, we developed a new strategy based on the combination of whole-blastocyst culture followed by laser drilling destruction of the trophoectoderm for improving the efficiency of inner cell mass (ICM) isolation and ES cell derivation using murine embryos. Embryos were divided into good- and poor-quality embryos. We demonstrate that the efficiency of both ICM isolation and ES cell derivation using this strategy is significantly superior to whole-blastocyst culture or laser drilling technology itself. Regardless of the ICM isolation method, the ES cell establishment depends on a feeder cell growth surface. Importantly, this combined methodology can be successfully applied to poor-quality blastocysts that otherwise would not be suitable for laser drilling itself nor immunosurgery in an attempt to derive ES cell lines due to the inability to distinguish the ICM. The ES cell lines derived by this combined method were characterized and shown to maintain a typical morphology, undifferentiated phenotype, and in vitro and in vivo three germ layer differentiation potential. Finally, all ES cell lines established using either technology acquired an aneuploid karyotype after extended culture periods, suggesting that the method used for ES cell derivation does not seem to influence the karyotype of the ES cells after extended culture. This methodology may open up new avenues for further improvements for the derivation of hES cells, the majority of which are derived from frozen, poor-quality human embryos.
The design of water supply network based on GIS (2008)

Water supply pipeline network is a system which has a large of spatial attribute data. In order to improve the manage and work efficiency, reducing the workload of workers, the best way is that designing a water supply network based on GIS, the system based on Arc GIS platform, using Client-Server and Browser-Server model to form a new composite model to set up the system. The paper introduces every function and the key technology of this system in detail, such as seamless integration of GIS of water supply pipeline network and hydraulic model which based on building pipeline network concise model dynamic and use the hydraulic calculation function to guarantee the authenticity of hydraulic model, hydraulic model which can help to simulate the whole system and analyze the condition of pipeline network, the model of pipe blowout statistical can help operator to know the condition of water pipe every segment in the system and forecast the events of pipe blowout, and according to the requirements of system, the fast locating algorithm was modified to reduce the time of searching objects. All these important technologies can strengthen the security, improve the speed of locating objects and help operator to analyze the pipeline condition. The system was tested in the laboratory environment and ran successfully, because it accords with the requirements of water supply network.
Tree based node verification key management scheme for wireless sensor networks (2019)

Sensor nodes are usually geographically placed across the particular environment. Sensor nodes are limited in capacities like computation power, memory, and processing speed. They collect sensitive information and send to the central base station. A novel TNVS is proposed that identifies certain nodes as authenticator nodes that have relatively high capability in storage, computation and power compared to the regular sensor nodes. These nodes are used for verifying new nodes that are being added into the network, thereby eliminating the entry of malicious nodes into the network. The master key that is shared by all the nodes of the network is renewed periodically to avoid node capture attack. Simulation and results show that in addition to providing authentication TNVS also requires less number of keys when compared to the existing key management schemes there by reducing the burden on memory requirement of the network.
The Development of Digestive Capacity in Young Pigs: Effects of Age and Weaning System (1982)

Two experiments with 49 crossbred pigs were conducted to examine the effects of age and weaning system on various indicators of digestive development and capacity. In Exp. 1, pigs reared exclusively by the sow with no access to creep feed were killed at 1, 8, 16 and 22 d of age. Other pigs, weaned at 16 d of age to a milk protein diet fed either in dry or liquid form, were killed at 22 d of age. In Exp. 2, pigs were reared exclusively by the sow and killed at 14, 17 and 21 d of age. All data are expressed as units per kilogram body weight. The pH of stomach contents increased during the first week of age. Stomach pH was higher in weaned pigs than in sow-reared pigs at 22 d of age. Sow-reared pigs showed little change with age in amount of stomach contents. Intestinal length tended to decrease with age. Intestinal weight per unit length increased with age and was higher in weaned pigs. Weaned pigs had a larger pancreas than pigs reared by the sow. In Exp. 1, proteolytic activity of stomach contents decreased with age until 22 d when an increase in activity occurred. The activity in weaned pigs was greater than that in sow-reared pigs. Intestinal trypsin activity increased at 22 d of age and was higher in weaned pigs. Intra-pancreatic trypsin activity increased from 1 to 8 d of age, after which there was little change. Less activity was found in the pancreas of weaned pigs than in that of sow-reared pigs of the same age. Intestinal chymotrypsin activity tended to increase with age. Weaned pigs had higher levels of activity in the intestine than did sow-reared pigs. Pancreatic chymotrypsin activity increased with age in sow-reared pigs. Lower levels of pancreatic chymotrypsin activity were found in weaned pigs than in sow-reared pigs. In Exp. 2, similar results were obtained with 14-, 17- and 21-d-old pigs. These results indicate that development of the digestive systemin the young pig undergoes dramatic changes from birth to 3 wk of age and at weaning.
Comparative analysis of the cytotoxicity of substituted [phenylglyoxal bis(4-methyl-3-thiosemicarbazone]copper(II) chelates (1976)

Seven para-substituted [phenylglyoxal bis(4-methyl-3-thiosemicarbazone)]copper (II) chelates (12-18) have been designed, synthesized, and tested for their ability to inhibit the respiration of rat liver slices as a normal cell model and Ehrlich ascites cells as a tumor cell model. Relationships between chemical structure and respiratory inhibition are described on a quantitative basis using substituent contants (pi, Es, and sigmap) by computerized multiparameter regression analyses. The correlations indicate that changes in Es have the largest effect on liver slice toxicity of chelates while pi and sigmap account for most of the variation in toxicity to ascites cells. A comparative analysis strongly suggests that electron-donating substituents with greater water solubility should increase cytotoxicity to ascites cells at the expense of cytotoxicity to the rat liver cells. The predictions of the equations were checked by synthesizing and testing an additional derivative. The results strengthen the initial predictions.
Inflammation, thrombosis and acute coronary syndromes (2005)

Inflammation plays a central role in the pathogenesis of acute coronary syndromes, the prevalence of which is increased in individuals with diabetes. Monocytes and macrophages, T cells and mast cells contribute to the initiation, development and rupture of atherosclerotic plaques by synthesising a variety of pro-inflammatory cytokines, including interleukin 1beta, interleukin 6 and tumour necrosis factor alpha. Cytokines upregulate endothelial cell adhesion molecules, recruit leukocytes and induce smooth muscle cell migration and proliferation. Cytokines act systemically to initiate the acute phase response, up-regulating proteins involved in inflammation and haemostasis and resulting in a pro-inflammatory and pro-thrombotic state. Expression of tissue factor by inflammatory cells potently induces thrombus formation upon plaque rupture, leading to acute coronary syndromes. Inflammatory biomarkers, including C-reactive protein, complement proteins, interleukin 6 and white blood cell count, predict development of acute coronary syndromes. C-reactive protein has been widely studied and consistently predicts future acute coronary syndrome events.
Genetic Forms of the Cardiometabolic Syndrome: What Can They Tell the Clinician? (2007)

A well-worn medical aphorism states that "when you hear hoof beats, think of a horse and not a zebra." When applying this principle to the cardiometabolic syndrome (CMS), the horse would be represented by the prevalent CMS phenotype that affects approximately 30% of individuals in Westernized societies, while the zebra is represented by very rare conditions--such as lipodystrophy syndromes--that share some features with the more prevalent CMS. For instance, familial partial lipodystrophy types 2 and 3 result from heterozygous mutations in LMNA, encoding nuclear lamin A/C, and in PPARG, encoding peroxisome proliferator-activated receptor (PPAR)-gamma, respectively. Patients with either subtype of partial lipodystrophy exhibit an increased ratio of central to peripheral fat stores, dysglycemia, dyslipidemia, and hypertension, with predisposition for developing insulin-resistant diabetes and atherosclerosis end points. Sometimes, however, the zebra serves as a model that can help us understand the horse, so that the rare partial lipodystrophies might offer some insight into pathogenesis and treatment of the more prevalent CMS.
SYNTHESES OF 7-SUBSTITUTED INDOLINE DERIVATIVES<sup>1, 2</sup> (1955)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSYNTHESES OF 7-SUBSTITUTED INDOLINE DERIVATIVES1, 2W. G. GALL, B. D. ASTILL, and V. BOEKELHEIDECite this: J. Org. Chem. 1955, 20, 11, 1538–1544Publication Date (Print):November 1, 1955Publication History Published online1 May 2002Published inissue 1 November 1955https://pubs.acs.org/doi/10.1021/jo01128a012https://doi.org/10.1021/jo01128a012research-articleACS PublicationsRequest reuse permissionsArticle Views414Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
On the Global Stabilization of Nonlinear Systems via Switching Manifolds (1999)

The global stabilization of nonlinear systems is investigated by using switching surfaces. The nonlinear system is forced to a lower order switching manifold, which is designed to be stable by construction. Thus, the stability of the reduced-order system is guaranteed and parameter selection for the switching surface is avoided. The method is extended to a class of uncertain nonlinear systems and exemplied with some ctitious dynamic models. 1.
Flow Cytometric Analysis of Kinase Signaling Cascades (2004)

Flow cytometry offers the capability to assess the heterogeneity of cellular subsets that exist in complex populations, such as peripheral blood, based on immunophenotypes. We describe methodologies to measure phospho-epitopes in single cells as determinants of intracellular kinase activity. Multiparametric staining, using both surface and intracellular stains, allows for the study of discrete biochemical events in readily discernible lymphocyte subsets. As such, the usage of multiparameter flow cytometry to obtain proteomic information provides several major advantages: (1) the ability to perform multiparametric experiments to identify distinct signaling profiles in defined lymphocyte populations, (2) simultaneous correlation of multiple active kinases involved in signaling cascades, (3) profiling of active kinase states to identify signaling signatures of interest rapidly, and (4) biochemical access to rare cell subsets such as those from clinically derived samples or populations that comprise too few in numbers for conventional biochemical analysis.