gebhart/patrepeval huggingface dataset:
Poly(sebacic acid‐<i>co</i>‐ricinoleic acid) biodegradable carrier for paclitaxel: <i>In vitro</i> release and <i>in vivo</i> toxicity (2004)

Polyesteranhydrides synthesized by the transesterification of ricinoleic acid and sebacic acid followed by anhydride polymerization were examined as potential controlled delivery carrier for paclitaxel. Solid and liquid polymers were used. Polymers containing 30% ricinoleic acid are solid whereas polymers containing 70% ricinoleic acid are liquid at body temperature and semisolid at room temperature. It was found that upon addition of the liquid polymer to water it solidifies to form a stable semisolid. Paclitaxel, a potent antitumor agent, was incorporated in the polymers (5-20% w/w) and its release in buffer solution was monitored. Paclitaxel was released for over 100 days while the polymer carrier was being degraded. The release rate was affected by the paclitaxel content; the higher the content, the slower was the release. The toxicity of the polymers and formulations with paclitaxel was examined by subcutaneous injection of liquid polymer samples or implantation of solid polymer specimens to mice for different time periods. Histopathological examination of the tissue surrounding the implant showed minor inflammation 1 week after the injection and no inflammation 3 weeks after implantation. Injection of the polymer without paclitaxel showed no adverse effects.
Parallel changes in puffing activity and patterns of protein synthesis in salivary glands of Drosophila. (1975)

The changes in protein synthesis of salivary glands of Drosophila resulting from a brief exposure at 37 degrees have been analyzed on sodium dodecyl sulfate--acrylamide gels. In D. melanogaster and D. hydei this treatment induces nine and six new puffs, respectively, in the polytene chromosomes. After 20 min treatment seven new proteins are synthesized by the glands of D. melanogaster and six by those of D. hydei as detected by [35S]methionine labeling. Other agents, e.g., recovery from anaerobiosis, induce the same puffs and the same proteins. The extent of protein induction and the degree of puff induction are related to the severity of the temperature treatment. The new proteins are detected after 10 min treatmene at 37 degrees and their synthesis is inhibited by actinomycin D. Actinomycin D added 5 min after the start of temperature treatment has little effect on subsequent protein synthesis. The induced proteins are not tissue specific. Electrophoretic differences of two proteins exist between D. melanogaster and D. simulans, encouraging attempts to map the proteins' gene loci and to test directly whether or not the puffs code for them.
Preparation of block copolyetheramides and their properties as hot melt adhesives (1989)

Abstract Block copolyetheramides were prepared by incorporating polyether into polyamide through melt polycondensation of polyetherdiamine, piperazine, dimer acid, and ε‐caprolactam. Bulk properties of block copolyetheramide, such as tensile strength, tensile modulus, elongation at break, hardness, and impact strength, were evaluated with respect to composition. Investigation on the lap shear strength and T‐peel strength of block copolyetheramide hot melt adhesive showed that the lap shear strength was more composition‐dependent. Moisture and elevating test temperature also reduced the lap shear strength significantly.
Avian feather mites (Acari: Astigmata) of Samsun, Turkey (2013)

Feather mites are one of the most important symbionts of birds, living on the feather, inside the quill, and in and on the skin. Approximately 2500 mite species from two superfamilies, Analgoidea and Pterolichoidea, have been described. Here, the feather mite fauna of 196 individuals of 42 bird species from the Kizilirmak delta, Turkey, was investigated. We detected a total of 30 feather mite species belonging to 14 genera and 9 families: Alloptes aythinae (Alloptidae); Analges passerinus, A. spiniger, A. turdinus, Strelkoviacarus quadratus (Analgidae); Avenzoaria totani (Avenzoariidae); Freyana nyrocae (Freyanidae); Grallolichus minutus (Pterolichidae); Dolichodectes edwardsi, Joubertophyllodes modularis, Monojoubertia microphylla, Proctophyllodes cetti, P. clavatus, P. doleophyes, P. lusciniae, P. mesocaulus, P. rubeculinus, P. scolopacinus, P. sylviae, P. troncatus (Proctophyllodidae); Pteronyssoides striatus, Scutulanyssus hirundicola (Pteronyssidae); Temnalges mesalgoides (Psoroptoididae); Trouessartia inexpectata, T. jedliczkai, T. kratochvili, T. microcaudata, T. reguli, T. rubecula and T. trouessarti (Trouessartiidae). These feather mite species are all first records for Turkey. New host association records are also noted: Analges spiniger on Cettia cetti, and Dolichodectes edwardsi on C. cetti and Sylvia melanocephala.
Microwave dielectric characterization of binary mixtures of water, methanol, and ethanol (1996)

The complex dielectric constants of binary mixtures of water–methanol and water–ethanol in the frequency range from 45 MHz to 26.5 GHz, and binary mixtures of methanol–ethanol in the range from 200 MHz to 26.5 GHz have been measured with various volume fractions around room temperature by means of an open-ended coaxial sensor and a network analyzer. Methanol–ethanol mixtures display a near-Debye dispersion while water–alcohol mixtures show a Cole–Davidson dispersion. The logarithm of relaxation time log τ and dielectric decrement Δε for methanol–ethanol mixtures show a good linear relation with the volume fraction of methanol, while log τ and Δε extracted with the Debye function for water–alcohol mixtures display a near-linear relation with volume fraction of water. Two simple formulas are proposed for identifying the volume fractions of the components in binary mixtures of alcohol–alcohol and water–alcohol from a knowledge of τ and Δε for the pure liquids and the mixtures. The validity of these formulas has been demonstrated with three blind tests. The relation between the mole fraction of water and log τ for water–methanol and water–ethanol mixtures extracted by the use of a Cole–Davidson function clearly shows two linear regions, which implies a change of relaxation mechanism with mole fraction.
Cholinergic System and Its Therapeutic Importance in Inflammation and Autoimmunity (2021)

Neurological and immunological signals constitute an extensive regulatory network in our body that maintains physiology and homeostasis. The cholinergic system plays a significant role in neuroimmune communication, transmitting information regarding the peripheral immune status to the central nervous system (CNS) and vice versa. The cholinergic system includes the neurotransmitter\ molecule, acetylcholine (ACh), cholinergic receptors (AChRs), choline acetyltransferase (ChAT) enzyme, and acetylcholinesterase (AChE) enzyme. These molecules are involved in regulating immune response and playing a crucial role in maintaining homeostasis. Most innate and adaptive immune cells respond to neuronal inputs by releasing or expressing these molecules on their surfaces. Dysregulation of this neuroimmune communication may lead to several inflammatory and autoimmune diseases. Several agonists, antagonists, and inhibitors have been developed to target the cholinergic system to control inflammation in different tissues. This review discusses how various molecules of the neuronal and non-neuronal cholinergic system (NNCS) interact with the immune cells. What are the agonists and antagonists that alter the cholinergic system, and how are these molecules modulate inflammation and immunity. Understanding the various functions of pharmacological molecules could help in designing better strategies to control inflammation and autoimmunity.
Intelligent group handover mode in multicell infrastructure (2004)

For the third generation systems' low frequency efficiency and small system capacity, there should be greatly changed in physical techniques in fourth generation mobile communication systems while many advanced techniques suited for high bite rate, high frequency efficiency and large dynamic range, such as JT, STC, MIMO, OFDMA, distributed antenna, are taken into considerations. But besides physical techniques, basic network layer techniques, e.g. the constructions of cellular and the modes of handover, must be broken through in the fourth generation mobile communication systems. The group cell structure proposed in WTI is a novel cellular construction method, which is fit well for these new advanced physical techniques. And slide handover (intelligent group handover) in multicell infrastructure is also novel handover mode emphasized in this paper. According to the current research, the slide handover in multicell infrastructure could improve the system capacity dramatically.
PM E CONSTITUINTE: POLICIAIS MILITARES COMPETENTES PARA ATUAR COMO POLÍCIA PREVENTIVA (1988)

Trabalho elaborado em marco de 1988 pelos policiais assessores parlamentares junto a Assembleia Nacional Constituinte
Ebola Hemorrhagic Fever and Septic Shock (2003)

Ebola virus is the cause of sporadic outbreaks of lethal Ebola hemorrhagic fever (EHF) in central Africa. Despite the difficulties of studying this virus much has been learned over the past decade about the pathogenesis of Ebola virus infection in humans and nonhuman primates. Two articles in this issue of the Journal of Infectious Diseases report further progress. The article by Bosio et al. confirms findings that the virus is able to infect dendritic cells (DCs) impairing their innate antiviral activity and limiting their ability to initiate adaptive immune responses. The article by Geisbert et al. identifies a molecular trigger for disseminated intravascular coagulation (DIC) through the expression of tissue factor (TF) on the surface of virus-infected monocytes and macrophages. Together these findings shed light on early events that both permit rapid viral dissemination and cause some of the major features of EHF. (excerpt)
A system for the electrophysiological monitoring of the spinal cord during operations for scoliosis (1983)

An electrophysiological system for monitoring the spinal cord during operations for scoliosis is described. During the development of the technique the recording of cortical somatosensory evoked potentials from the scalp and spinal somatosensory evoked potentials from the laminae or spines was superseded by the positioning of recording electrodes in the epidural space cephalad to the area to be fused. All recordings were made in response to stimulation of the posterior tibial nerve at the knee. Results in 138 patients are presented and the findings in three patients who exhibited neurological deficits after operation are described. It is concluded that spinal somatosensory evoked potentials are sensitive to minor spinal cord impairment, possible due to ischaemia, and that these changes may be reversed when the cause is quickly remedied. The monitoring system interferes minimally with anaesthetic and surgical procedures and is now performed as a routine.
Physiologic and pharmacologic implications of fibrinolysis. (1979)

According to the thrombogenetic (encrustation) theory of atherogenesis first postulated by Rokitansky, accretions of blood components including fibrin and platelets may be the initial event. Since fibrinolysis has a profound influence on the resolution of fibrin deposits, the role of fibrinolysis in atherogenesis is discussed. Evidences supporting this role include the demonstration of inhibitors of fibrinolysis, decreased circulating fibrinolytic activity in patients who are atherosclerotic, and inhibition of circulating fibrinolytic activity by several atherosclerosis-risk factors such as increasing age, cigarette smoking, hypercholesterolemia, hypertriglyceridemia and diabetes mellitus. It is concluded that a combination of systemic inhibitions of fibrinolysis over a long-term period and a local vascular injury, play a decided role in atherogenesis.
SensorSift (2012)

We introduce SensorSift, a new theoretical scheme for balancing utility and privacy in smart sensor applications. At the heart of our contribution is an algorithm which transforms raw sensor data into a 'sifted' representation which minimizes exposure of user defined private attributes while maximally exposing application-requested public attributes. We envision multiple applications using the same platform, and requesting access to public attributes explicitly not known at the time of the platform creation. Support for future-defined public attributes, while still preserving the defined privacy of the private attributes, is a central challenge that we tackle.
Litigation Outcome Prediction of Differing Site Condition Disputes through Machine Learning Models (2011)

The construction industry is one of the main sectors of the U.S. economy that has a major effect on the nation’s growth and prosperity. The construction industry’s contribution to the nation’s economy is, however, impeded by the increasing number of disputes that unfold and oftentimes escalate as projects progress. The majority of construction disputes are resolved in courts unless project contracts call for alternate dispute resolution mechanisms. Despite the numerous advantages offered by the litigation process, the extra financial burdens and additional time required by this process makes litigation less desirable in resolving the disputes of a very dynamic construction industry. It is believed that construction litigation could be reduced or even avoided if parties have a realistic understanding of their actual legal position and the likely outcome of their case. Consequently, researchers in the artificial intelligence field have developed tools and methodologies for modeling judicial reasoning and predicting the outcomes of construction litigation cases. Despite the success of some of these systems, they were not on the basis of detailed analyses of legal concepts that govern litigation outcomes. In an attempt to provide a robust legal decision methodology for the construction industry, this paper develops an automated litigation outcome prediction method for differing site condition (DSC) disputes through machine learning (ML) models. To develop the proposed method, this paper compares the performance of three ML techniques, namely: support vector machines (SVMs), naïve Bayes, and rule induction and neural network classifiers (decision trees, boosted decision trees, and the projective adaptive resonance theory). The models were trained and tested using 400 DSC cases filled in the period from 1912 to 2007. Model predictions are on the basis of significant legal factors that govern verdicts in DSC disputes in the construction industry. The third-degree SVM polynomial model performed the best among the nine ML models that were developed, and achieved a prediction precision of 98%.
Electrode fabrication for Li-ion: processing, formulations and defects during coating (2002)

The chemistry of the constituent electrode/electrolytes determines the electrochemical stability, reversibility and kinetics of the Li insertion/extraction process and hence limits the performance of Li-ion batteries. However, mechanical stability/configuration of the electrodes is equally important for extended cycle life and is largely determined by the electrode processing and fabrication techniques. Inhomogeneous distribution of the binders and active materials on the electrodes resulting from variations in rheological parameters for the slurry/suspension during formulation and additional defects introduced during processing/fabrication not only lead to poor adhesion and subsequent mechanical failure by delamination, but also result in electrode thickness, porosity and density variations which severely affect the chemistry of the insertion process. The purpose of this paper is to: (1) evaluate the various possible electrode defects with different fabrication techniques used for small scale, specialty purpose Li-ion electrode fabrication such as the aqueous/nonaqueous pasting process, and doctor-blade/web-coating methods and (2) examine the origin of defects and role of curing, drying and electrode formulations which affect the adhesion, coating defects and hence influence the subsequent electrochemical characteristics.
Sterol carrier protein-2 localization in endoplasmic reticulum and role in phospholipid formation (2000)

Although sterol carrier protein-2 (SCP-2; also called nonspecific lipid transfer protein) binds fatty acids and fatty acyl-CoAs, its role in fatty acid metabolism is not fully understood. L-cell fibroblasts stably expressing SCP-2 were used to resolve the relationship between SCP-2 intracellular location and fatty acid transacylation in the endoplasmic reticulum. Indirect immunofluorescence double labeling and laser scanning confocal microscopy detected SCP-2 in peroxisomes > endoplasmic reticulum > mitochondria > lysosomes. SCP-2 enhanced incorporation of exogenous [(3)H]oleic acid into phospholipids and triacylglycerols of overexpressing cells 1.6- and 2.5-fold, respectively, stimulated microsomal incorporation of [1-(14)C]oleoyl-CoA into phosphatidic acid in vitro 13-fold, and exhibited higher specificity for unsaturated versus saturated fatty acyl-CoA. SCP-2 enhanced the rate-limiting step in microsomal phosphatidic acid biosynthesis mediated by glycerol-3-phosphate acyltransferase. SCP-2 also enhanced microsomal acyl-chain remodeling of phosphatidylethanolamine up to fivefold and phosphatidylserine twofold, depending on the specific fatty acyl-CoA, but had no effect on other phospholipid classes. In summary, these results were consistent with a role for SCP-2 in phospholipid synthesis in the endoplasmic reticulum.
Practical Applications of Motor Imagery EEG Based on BP Neural Networks (2012)

In the application of the classification, neural networks are often used as a classification tool, In this paper, neural network is introduced on motor imagery EEG analysis, the first EEG Hjort conversion, and then the brain electrical signal is converted into the frequency domain, Finally, the fisher distance for feature extraction in the EEG analysis, identification of the study sample was 97 86% recognition rate is 80% of the test sample.
Noninvasive Imaging of Tumor PD-L1 Expression Using Radiolabeled Anti–PD-L1 Antibodies (2015)

Antibodies that block the interaction between programmed death ligand 1 (PD-L1) and PD-1 have shown impressive antitumor activity. Patients with tumors expressing PD-L1 are most likely to respond to this treatment. The aim of our study was to develop a noninvasive imaging technique to determine tumor PD-L1 expression in vivo. This could allow selection of patients that are most likely to benefit from anti-PD-1/PD-L1 treatment and to monitor PD-L1 expression during therapy. The monoclonal antibody PD-L1.3.1 was radiolabeled with Indium-111 ((111)In) and characterized using PD-L1-expressing MDA-MB-231 cells. Subsequently, the optimal antibody dose and time point for imaging was determined in mice with MDA-MB-231 xenografts. Finally, SPECT/CT imaging was performed in xenograft models with different PD-L1 expression levels and tumor sections were analyzed for PD-L1 expression using IHC. The optimal antibody dose of (111)In-PD-L1.3.1 (Kd = 1 nmol/L) for SPECT/CT imaging was ≤1 μg. Highest tumor-to-normal tissue contrast was obtained at days 3 and 7 after injection. (111)In-PD-L1.3.1 SPECT/CT showed efficient accumulation in high PD-L1-expressing tumors (MDA-MB-231 and SK-Br-3), whereas no specific uptake was observed in tumors with low or no detectable levels of PD-L1 (SUM149, BT474, and MCF-7). SPECT/CT and autoradiography showed a very heterogeneous distribution of (111)In-PD-L1.3.1 within the tumor. In conclusion, this is the first study showing the feasibility of noninvasive in vivo imaging of PD-L1 expression in tumors. (111)In-PD-L1.3.1 showed efficient and specific uptake in PD-L1 expressing xenografts. This technique may enable patient selection for PD-1 and PD-L1-targeted therapy.
Design of Antibacterial Surfaces and Interfaces: Polyelectrolyte Multilayers as a Multifunctional Platform (2009)

The adhesion and proliferation of bacteria on abiotic surfaces pose challenges related to human infection, including subsequent formation of antibiotic-resistant biofilms in both healthcare and industrial applications. Although the design of antibacterial materials is a longstanding effort, the surface properties that modulate adhesion of viable bacteria—the critical first step in biofilm formation—have been difficult to decouple. This partial and limited success is due chiefly to two factors. First, bacteria cells exhibit multiple, complex adhesion mechanisms that vary with bacteria strain, rapid genetic mutations within a given strain, and mutable environmental stimuli such as nutrient levels and fluid velocities. Second, there exist only a limited number of studies that systematically characterize or vary the physical, chemical, and mechanical properties of potential antimicrobial materials. Here, we briefly review the dominant strategies for antimicrobial material surface design, including the advantages and limitations of approaches developed via synthetic and natural polymers. We then consider polyelectrolyte multilayers (PEMs) as a versatile materials platform to adopt and integrate these strategies, as well as to elucidate the individual contributions of tunable material properties that limit viable bacteria adhesion. Together, these findings suggest that PEMs can be tailored to leverage the key advantages of bacterial adhesion resistance, contact killing, and biocide leaching strategies for a wide range of antimicrobial surface applications.
Ted Wheelwright Memorial Lecture: Understanding the Economic Crisis - the Importance of Training in Critical Economics (2009)

Jim Stanford delivers a lecture at the University of Sydney in the name of Ted Wheelwright, one of the pioneers of the political economy movement. The importance of a critical economics pedagogy to social change movements is the central topic of his presentation.
PRIMER CURSO DE PERIODISMO FOREST (1983)

SE REQUIERE IMPLEMENTAR UNA POLITICA CULTUR FOREST QUE CONTEMPLE LOS INTERESES DE LOS CAMPESINOS, PUES SOLO DE ESTA FORMA SE DARA SOLUCION A LOS PROBLEMAS FORESTES, INDICARON LEON JORGE CASTANOS, SUBSECRARIO FOREST DE LA SECRARIA DE AGRICULTURA Y RECURSOS HIDRAULICOS (SARH) Y LEOPOLDO BORRAS SANCHEZ, DIRECTOR GENER DE LA UNIDAD DE APOYO TECNICO DE LA PROPIA SUBSECRARIA FOREST, INTERVENIR EN LA INAUGURACION DEL PRIMER CURSO DE PERIODISMO FOREST, IMPARTIDO EN LA FACULTAD DE CIENCIAS POLITICAS Y SOCIES (FCPYS).
Liquid Crystal Tunable mm Wave Frequency Selective Surface (2007)

A frequency selective surface (FSS) which exploits the dielectric anisotropy of liquid crystals to generate an electronically tunable bandpass filter response at D Band (110-170 GHz) is presented. The device consists of two printed arrays of slot elements which are separated by a 130-mum thick layer of liquid crystals. A 3% shift in the filter passband occurs when the substrate permittivity is increased by applying a control signal of 10 V. Measured results show that the insertion loss increases from -3.7 dB to -10.4 dB at resonance (134 GHz), thus demonstrating the potential to create a FSS which can be switched between a transmitting and a reflecting structure.