gebhart/patrepeval huggingface dataset:
Methylothermus subterraneus sp. nov., a moderately thermophilic methanotroph isolated from a terrestrial subsurface hot aquifer (2010)

A novel methane-oxidizing bacterium, strain HTM55(T), was isolated from subsurface hot aquifer water from a Japanese gold mine. Strain HTM55(T) was a Gram-negative, aerobic, motile, coccoid bacterium with a single polar flagellum and the distinctive intracytoplasmic membrane arrangement of a type I methanotroph. Strain HTM55(T) was a moderately thermophilic, obligate methanotroph that grew on methane and methanol at 37-65 °C (optimum 55-60 °C). The isolate grew at pH 5.2-7.5 (optimum 5.8-6.3) and with 0-1 % NaCl (optimum 0-0.3 %). The ribulose monophosphate pathway was operative for carbon assimilation. The DNA G+C content was 54.4 mol% and the major fatty acids were C(16 : 0) (52.0 %) and C(18 : 1)ω7c (34.8 %). Phylogenetic analysis of the 16S rRNA gene sequence indicated that strain HTM55(T) was closely related to Methylothermus thermalis MYHT(T) (99.2 % 16S rRNA gene sequence similarity), which is within the class Gammaproteobacteria. However, DNA-DNA relatedness between strain HTM55(T) and Methylothermus thermalis MYHT(T) was ≤ 39 %. On the basis of distinct phylogenetic, chemotaxonomic and physiological characteristics, strain HTM55(T) represents a novel species of the genus Methylothermus, for which the name Methylothermus subterraneus sp. nov. is proposed. The type strain is HTM55(T) ( = JCM 13664(T) = DSM 19750(T)).
Recursive Maximum Entropy Algorithm and its Application to the Luminescence Lifetime Distribution Recovery (2000)

A simple algorithm, based on recursive quadratic optimization, is suggested for the numerical inversion of integral transforms. The algorithm was found particularly useful for “small scale” problems, with the number of independent parameters ranging between 100 and 200. The programming, parameterization, and performance of the algorithm are discussed, as well its application to the analysis of time-resolved luminescence data.
Asymmetric excitation of surface plasmons by dark mode coupling (2016)

Asymmetric excitation of surface plasmons is achieved by classical dark mode coupling, promising metadevices with unique functionalities.
Über Azophosphonsäureester (1958)

Abstract Die Einwirkung von Diazonium‐Verbindungen auf Dialkylester der phosphorigen Säure führt zu rot gefärbten, relative stabilen Azophosphonsäureestern. Diese werden durch Reduktionsmittel in Hydrazino‐phosphonsäureester überführt, die nach Hydrolyse Arylhydrazine ergeben. Die unter Stickstoff‐Entwicklung ablaufende Zersetzung der Azophosphonsäureester durch Alkali wird aufgeklärt.
Cycloheximide prevents apoptosis, reactive oxygen species production, and glutathione depletion induced by transforming growth factor beta in fetal rat hepatocytes in primary culture (1997)

We have previously reported that transforming growth factor-beta (TGF-beta) induces apoptosis in fetal hepatocytes in primary culture. This effect was found to be associated with an increase in intracellular reactive oxygen species (ROS) and a lowering of total cellular reduced glutathione (GSH). In this study, we investigated whether protein synthesis plays a role in these TGF-beta-induced effects. When fetal hepatocytes were incubated in the presence of cycloheximide, a specific protein synthesis inhibitor, TGF-beta-induced apoptosis was completely blocked. The overall intracellular oxidized state of the cells, when measured using either 2',7'-dichlorofluorescein diacetate (DCFH) by laser-scanning confocal microscopy, or both DCFH and hydroethidine (DHE) by flow cytometric analysis, was increased transiently after the addition of TGF-beta. This increase was abolished by incubation of the cells in the presence of cycloheximide. Furthermore, the decrease in the total cellular GSH content induced by TGF-beta in these cells was not observed when cycloheximide was present. Cycloheximide effect was not associated with an enhancement of cysteine and restoration of cellular glutathione level, because inhibition of GSH synthesis with buthionine sulfoximine (BSO) did not prevent the cycloheximide protective effect. Experiments performed to check whether Fas (APO-1) ligand might be the protein that needs to be synthesized have indicated that this possibility can be excluded. All these findings suggest that apoptosis elicited by TGF-beta in fetal hepatocytes requires the synthesis of an unknown protein before ROS production, glutathione loss, and oxidative stress. (Hepatology 1997 Oct;26(4):935-43)
Rapid and Selective Determination of Free Barbiturates by Gas Chromatography Using the Electrolytic Conductivity Detector (1975)

A rapid and specific gas chromatographic method for the analysis of free barbiturates in serum and urine at all levels of clinical interest is described. The method employs an improved electrolytic conductivity detector, and can be used for the determination of barbiturate levels of 0.01 mg/dl without sample clean-up. The preparation of columns for the analysis of nanogram quantities of free barbiturates is also discussed.
Carotid Endarterectomy: The Gold Standard (1996)

Carotid endarterectomy has been firmly established as the gold standard of therapy for symptomatic and asymptomatic patients with severe carotid stenosis, provided surgical complication rates are within prescribed limits. The procedure-related risk of stroke/death should be < 3% in asymptomatic patients and < 6% in symptomatic patients. New investigational therapies such as balloon angioplasty and stenting for carotid stenosis should be evaluated against the same standard.
Endothelium-Targeted Gene and Cell-Based Therapies for Cardiovascular Disease (2004)

Most common cardiovascular diseases are accompanied by endothelial dysfunction. Because of its predominant role in the pathogenesis of cardiovascular disease, the vascular endothelium is an attractive therapeutic target. The identification of promoter sequences capable of rendering endothelial-specific transgene expression together with the recent development of vectors with enhanced tropism for endothelium may offer opportunities for the design of new strategies for modulation of endothelial function. Such strategies may be useful in the treatment of chronic diseases such as hypertension, atherosclerosis, and ischemic artery disease, as well as in acute myocardial infarction and during open heart surgery for prevention of ischemia and reperfusion (I/R)-induced injury. The recent identification of putative endothelial progenitor cells in peripheral blood may allow the design of autologous cell-based strategies for neovascularization of ischemic tissues and for the repair of injured blood vessels and bioengineering of vascular prosthesis. "Proof-of-concept" for some of these strategies has been established in animal models of cardiovascular disease. However the successful translation of these novel strategies into clinical application will require further developments in vector and delivery technologies. Further characterization of the processes involved in mobilization, migration, homing, and incorporation of endothelial progenitor cells into the target tissues is necessary, and the optimal conditions for therapeutic application of these cells need to be defined and standardized.
Epilation induces hair and skin pigmentation through an EDN3/EDNRB-dependent regenerative response of melanocyte stem cells (2017)

In response to various types of injury, melanocyte stem cells (McSCs) located in the bulge of hair follicles can regenerate mature melanocytes for hair and skin pigmentation. How McSCs respond to injury, however, remains largely unknown. Here we show that after epilation of mice, McSCs regenerate follicular and epidermal melanocytes, resulting in skin and hair hyperpigmentation. We further show that epilation leads to endogenous EDN3 upregulation in the dermal papilla, the secondary hair germ cells, and the epidermis. Genetic and pharmacological disruption of the EDN3 receptor EDNRB in vivo significantly blocks the effect of epilation on follicular and epidermal melanocyte regeneration as well as skin and hair hyperpigmentation. Taken together, these results indicate that epilation induces McSCs activation through EDN3/EDNRB signaling and in turn leads to skin and hair hyperpigmentation. The findings suggest that EDN/EDNRB signaling may serve as a potential therapeutic target to promote repigmentation in hypopigmentation disorders.
Pt nanoparticle netlike-assembly as highly durable and highly active electrocatalyst for oxygen reduction reaction (2011)

A Pt nanoparticle netlike-assembly (Pt-NNA) synthesized through a facile hydrothermal method, with high specific surface area and large overall size, exhibits much higher durability and 2.9 times higher mass activity for oxygen reduction reaction than commercial Pt black catalyst.
Equilibrium Adsorption Isotherms for H<sub>2</sub>O on Zeolite 13X (2019)

Adsorption isotherms are reported for pure water vapor on zeolite 13X (also called zeolite NaX) pellets. Data were obtained using a gravimetric method over a temperature range of 25 to 100 °C and a pressure range of 0.006 to 25 kPa. These pure-component equilibria are fit with the Sips, Toth, and multisite Langmuir models, all modified with the Aranovich–Donohue (A–D) model. The A–D Sips isotherm is recommended for modeling water adsorption on zeolite 13X because it provides the best agreement with the measured isotherm data.
Sterically-Hindered Amines for Acid-Gas Absorption (1987)

Abstract This paper reviews sterlcally-hindered amines for removal of add gases such as CO2 and H2S from gaseous streams. Steric hindrance of amines reduces carbamate stability. Moderately hindered amines are characterized by high rates of CO2 absorption and high capacities for CO2. The moderately hindered amine in use with organic solvent has considerably higher capacity than the conventional amine-solvent system for simultaneous removal of CO2and H2S from synthesis gas and natural gas. A severely-hindered-amine absorbent, characterized by a very low rate of CO2absorption, has much higher capacity and selectivity than the current industry standard, methyldiethanolamine, for selective removal of H2S from CO2-containing streams. Use of hindered amines represents new advances in gas treating. Hindered amines save energy and capital in gas treating significantly. In addition, hindered amines used commercially have much better stability than conventional amines. As of today, fourteen commercial plants use hindered amines.
Computing Communities in Large Networks Using Random Walks (2006)

Dense subgraphs of sparse graphs (communities), which appear in most real-world complex networks, play an important role in many contexts.Computing them however is generally expensive.We propose here a measure of similarities between vertices based on random walks which has several important advantages: it captures well the community structure in a network, it can be computed efficiently, it works at various scales, and it can be used in an agglomerative algorithm to compute efficiently the community structure of a network.We propose such an algorithm which runs in time O(mn 2 ) and space O(n 2 ) in the worst case, and in time O(n 2 log n) and space O(n 2 ) in most real-world cases (n and m are respectively the number of vertices and edges in the input graph).Experimental evaluation shows that our algorithm surpasses previously proposed ones concerning the quality of the obtained community structures and that it stands among the best ones concerning the running time.This is very promising because our algorithm can be improved in several ways, which we sketch at the end of the paper.
Fenfluramine and Dextroamphetamine Treatment of Childhood Hyperactivity (1989)

• Twenty boys (mean age, 9 ± 2 years) with attention deficit disorder with hyperactivity received three weeks each of dextroamphetamine sulfate (0.5 mg/kg/d), fenfluramine hydrochloride (0.6 mg/kg/d increased to 2.0 mg/kg/d), and placebo in a double-blind, random-order, crossover design. Half the boys also met criteria for conduct disorder. Dextroamphetamine produced immediate and marked improvement in disruptive, overactive behaviors. Fenfluramine had no effect on any behavioral measure at either the low or high dosage. Both drugs decreased levels of urinary norepinephrine, 3-methoxy4-hydroxyphenylglycol (MHPG), and vanillylmandelic acid. Fenfluramine, however, also produced a significant decrease in plasma MHPG levels and a larger decrease in urinary norepinephrine levels. It reduced urinary epinephrine levels as well, an effect opposite to that of dextroamphetamine. These findings suggest that different mechanisms of action are involved in the ability of the two drugs to reduce levels of MHPG and vanillylmandelic acid. Fenfluramine increased plasma prolactin levels and decreased platelet serotonin levels. Despite the structural similarity of the two drugs, some common overall effects on catecholamine metabolism, and similar effects on weight, fenfluramine had none of the motor activity or therapeutic effects of dextroamphetamine.
Coloration and decoloration of glasses by photo-irradiation and heat treatment for easily recycled glass products (2003)

We have been developing a technique of coloration and decoloration of glasses by photo-irradiation and heat-treatment for application to easily recyclable colored glass products. The mechanisms of the photo-induced coloration of glasses used in this research are a) the photo-induced defects (color centers) formation, b) the photo-induced change in oxidation state of ions, and c) the photo-induced formation of nanoparticles in glasses. The subjects for application of these phenomena to recyclable colored-glass products are presented. The research examples for each mechanism are presented in this paper as follows: 1) the effect of the doped Fe ions on the optical density and stability of coloration due to color centers, 2) the coloration by the change in oxidation state, (formula available in paper) and 3) the reversible coloration and decoloration for an Ag single-doped glass.
Cost-Effective Connection Details for Highway Sign, Luminaire, and Traffic Signal Structures (2011)

This report documents the results of a comprehensive experimental and analytical study that evaluated fatigue performance of several critical welded connections in the highway sign, signal and high-level luminaire support structures. In this study, infinite life fatigue resistance of connection details in the existing inventory was established and new cost-effective fatigue resistant connections were developed. About 80 full size galvanized specimens of sign, signal and high-level luminaire support structures containing different welded connections were fatigue tested. Using parametric Finite Element Analyses (FEA) of 3D models verified by test data, fatigue performance of the connections in both finite and infinite life regimes were defined in terms of fatigue stress concentration factors over the range of applicable geometric dimensions. The study demonstrated that tube-to-transverse plate connections are the most fatigue critical details in the subject structures. Increasing the stiffness of the transverse plate is the most cost-effective means of improving fatigue resistance of this connection. Groove welded connections with smaller opening in the plate exhibits largest fatigue resistance. Sharper bend radius and less number of sides reduce fatigue threshold of connections in multi-sided sections. Based on these research findings, new specification recommendations were proposed for revision to the existing AASHTO specifications.
Controller interface for controller-pilot data link communications (2002)

The controller interface was designed to generate air traffic controller messages per RTCA DO-219 for Controller-Pilot data link communications (CPDLC). The controller interface is part of the low visibility landing and surface operations (LVLASO) project being researched by NASA's Langley and Ames Research Centers. The messages implemented in the controller interface were tailored for the ground controller to handle airport surface traffic. Of primary concern were messages related to taxi routes and hold short instructions. These messages drive the moving map display in the NASA 757 research aircraft. The controller interface, using voice recognition and a touch screen for controller input, was tested at Atlanta Hartsfield Airport in August 1997.
Future easy and physiological cardiac pacing (2011)

The right atrial appendage (RAA) and right ventricular apex (RVA) have been widely considered as conventional sites for typical dual-chamber atrio-ventricular cardiac (DDD) pacing. Unfortunately conventional RAA pacing seems not to be able to prevent atrial fibrillation in DDD pacing for tachycardia-bradycardia syndrome, and the presence of a left bundle branch type of activation induced by RVA pacing can have negative effects. A new technology with active screw-in leads permits a more physiological atrial and right ventricular pacing. In this review, we highlight the positive effects of pacing of these new and easily selected sites. The septal atrial lead permits a shorter and more homogeneous atrial activation, allowing better prevention of paroxysmal atrial fibrillation. The para-Hisian pacing can be achieved in a simpler and more reliable way with respect to biventricular pacing and direct Hisian pacing. We await larger trials to consider this "easy and physiological pacing" as a first approach in patients who need a high frequency of pacing.
Superviews: Virtual Integration of Multiple Databases (1987)

An important advantage of a database system is that it provides each application with a custom view of the data. The issue addressed in this paper is how to provide such custom views to applications that access multiple databases. The paper describes a formal method that generates such superviews, in an interactive process of schema editing operations. A mapping of the superview into the individual databases is derived from the editing process, and is stored together with the superview as a virtual database. When this database is interrogated, the mapping is used to decompose each query into a set of queries against the individual databases, and recompose the answers to form an answer to the original query. As this process is transparent to the user, virtual databases may be regarded as a more general type of databases. A prototype database system, that allows users to construct virtual databases and interrogate them, has been developed.
Potential Use of Home HIV Testing (1995)

The Food and Drug Administration is considering whether or not to approve diagnostic kits for infection with the human immunodeficiency virus (HIV) that would allow blood collection at home. A person would use a lance provided in the kit to obtain blood from a finger, place a drop on a filter paper, and mail the specimen to a laboratory, where screening and confirmatory tests, if necessary, would be performed. The results would be obtained over the telephone through the use of a code number. As discussed elsewhere in this issue of the Journal,1 proponents of these tests believe that . . .
The design of human-powered access technology (2011)

People with disabilities have always overcome accessibility problems by enlisting people in their community to help. The Internet has broadened the available community and made it easier to get on-demand assistance remotely. In particular, the past few years have seen the development of technology in both research and industry that uses human power to overcome technical problems too difficult to solve automatically. In this paper, we frame recent developments in human computation in the historical context of accessibility, and outline a framework for discussing new advances in human-powered access technology. Specifically, we present a set of 13 design principles for human-powered access technology motivated both by historical context and current technological developments. We then demonstrate the utility of these principles by using them to compare several existing human-powered access technologies. The power of identifying the 13 principles is that they will inspire new ways of thinking about human-powered access technologies.
The Objective Assessment of Fabric Pilling. Part I: Methodology (1993)

Abstract The paper describes the application of laser triangulation to the grading of fabric pilling. Part II goes further to compare the experimental results with the corresponding gradings as assessed by a panel of experts.
Amino Acid Sequence of the Maize Ferredoxin: Thioredoxin Reductase Variable Subunit (1996)

The ferredoxin:thioredoxin reductase (FTR) is the essential enzyme of the light dependent regulatory system controlling enzyme activities in oxygenic, photosynthetic cells. This protein is composed of two dissimilar subunits, a catalytic subunit containing a [4Fe-4S] cluster and a redox-active disulfide bridge as the active site, and a variable subunit, whose function is not known yet. Whereas size and primary structure of the catalytic subunit from different organisms seem to be well conserved, they are quite variable for the variable subunit. Here we report the complete amino acid sequence of the variable subunit of maize (Zea mays) FTR established by protein sequencing. The subunit contains 97 residues and has a calculated molecular mass of 10939 Da. A sequence comparison shows 40% identity with the variable subunit from spinach and 38% with the one from Anacystis. The identical residues are grouped in three consensus domains, one near the N-terminus, one in the middle of the subunit and one near the C-terminus. We have obtained some evidence indicating that the N-terminal consensus domain is possibly involved in the interaction with the catalytic subunit.
Tumor therapy with hematoporphyrin derivative and lasers via a percutaneous fiberoptic technique: preclinical experiments. (1987)

Photodynamic therapy relies on uptake of a photosensitizer (hematoporphyrin derivative [HpD]) by tumor cells and subsequent interaction of the photosensitizer with penetrating light. This technique has been applied in multiple animal systems and several clinical trials. The therapeutic results in large, deep tumors are limited by poor uptake and distribution of the HpD and limited penetration of tumors by light, even at high wavelengths. In various experiments with mice, HpD was injected into tumors, and light was applied via laser fiberoptics inserted through a sheath catheter. Preliminary findings indicated that intratumoral injection enables excellent distribution of HpD in high concentrations, thus optimizing the sensitivity of the tumor cells. The sheath catheter and fiberoptics enable excellent distribution of light. Experiments with T-cell lymphomas demonstrated significant response of the tumors to the combination of intratumoral HpD and interstitial light application.