gebhart/patrepeval huggingface dataset:
Effects of certain arylhydroxamic acids on deoxy-ribonucleic acid synthesis by Ehrlich ascites tumor cells in vitro (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffects of certain arylhydroxamic acids on deoxy-ribonucleic acid synthesis by Ehrlich ascites tumor cells in vitroGlen R. Gale and John B. HynesCite this: J. Med. Chem. 1968, 11, 1, 191–194Publication Date (Print):January 1, 1968Publication History Published online1 May 2002Published inissue 1 January 1968https://pubs.acs.org/doi/10.1021/jm00307a058https://doi.org/10.1021/jm00307a058research-articleACS PublicationsRequest reuse permissionsArticle Views84Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
<i>In Vivo</i>Expression of Insulin-Like Growth Factor-Binding Protein-2 in Human Gliomas Increases with the Tumor Grade<sup>1</sup> (2001)

Human central nervous system tumors and glioma cell lines highly express the insulin-like growth factor-binding protein (IGFBP)-2. As IGFBP-2 can affect tumor growth, we studied the relationship between IGFBP-2 expression and the malignancy of brain tumors in vivo. To do so, we investigated by immunohistochemistry the accumulation of IGFBP-1, -2, and -3 in 50 human gliomas classified by the WHO Malignancy Scale. Double labeling using anti-CD68 (monocytes/macrophages), antiglial fibrillary acidic protein, and anti-CD3 (T cells) antibodies was performed to further characterize the IGFBP-1, -2, and -3(+) cells. The expression of IGFBP messenger RNAs (mRNAs) was tested by RT-PCR in tumor samples from nine gliomas of different grades and in eight cell lines representing the cellular composition of human glioma. As controls, the accumulation of IGFBP-2 was investigated in normal brain and in the rat C6 glioblastoma model. IGFBP-1 and -3 accumulated in endothelial and macrophage/microglial cells. IGFBP-2(+) macrophage/microglial and glioma cells clustered in the immediate vicinity of focal necrosis of the human gliomas as well as of the rat C6 glioblastoma. The labeling score of IGFBP-1 accumulation in endothelial cells correlated negatively (P: = 0.0229), and that of IGFBP-2 accumulation in glioma cells correlated positively (P: < 0.0006) with the tumor grade of the gliomas. In addition, RT-PCR analysis confirmed mRNA expression of IGFBP-1, -2, and -3 by the gliomas and glial cells. Small amounts of IGFBP-1 and -3 mRNA, but high amounts of IGFBP-2 mRNA, were detectable in macrophage-like and glioma cell lines. The results suggest cell type-specific accumulation of IGFBP-1, -2, and -3 in human glial tumors of the brain. The increase in IGFBP-2 expression with this malignancy suggests a role of IGFBP-2 in the biology of human gliomas.
A NOVEL INTEGRATED PCA AND FLD METHOD ON HYPERSPECTRAL IMAGE FEATURE EXTRACTION FOR CUCUMBER CHILLING DAMAGE INSPECTION (2004)

High-resolution hyperspectral imaging (HSI) provides an abundance of spectral data for feature analysis in imageprocessing. Usually, the amount of information contained in hyperspectral images is excessive and redundant, and data miningfor waveband selection is needed. In applications such as fruit and vegetable defect inspections, effective spectral combinationand data fusing methods are required in order to select a few optimal wavelengths without losing the crucialinformation in the original hyperspectral data. In this article, we present a novel method that combines principal componentanalysis (PCA) and Fishers linear discriminant (FLD) method to show that the hybrid PCA-FLD method maximizes the representationand classification effects on the extracted new feature bands. The method is applied to the detection of chillinginjury on cucumbers. Based on tests on different types of samples, results show that this new integrated PCA-FLD methodoutperforms the PCA and FLD methods when they are used separately for classifications. This method adds a new tool forthe multivariate analysis of hyperspectral images and can be extended to other hyperspectral imaging applications for fruitand vegetable safety and quality inspections.
A Formal Synthesis of Psymberin (2007)

A formal synthesis of psymberin (irciniastatin A) is presented. Notable features of the synthesis include the chemo-, regio-, and stereoselective oxidation of a 1,3-disubstituted allene, a configuration-dependent spirodiepoxide opening, the efficient syntheses of functionalized trans-2,6-disubstituted pyrans, and the union of a highly functionalized aldehyde with a pentasubstituted aryl homoenolate to give a dihydroisocumarin. [structure: see text]
Antigenic and immunogenic properties of defined physical forms of tick-borne encephalitis virus structural proteins (1981)

Polymeric, delipidated glycoprotein complexes of defined size and composition were prepared from tick-borne encephalitis virus by solubilization with Triton X-100 or cetyltrimethylammonium bromide, followed by centrifugation into detergent-free sucrose density gradients. The antigenic reactivities and immunogenicities of these complexes were compared with those of complete inactivated virus. These glycoprotein preparations induced hemagglutination-inhibiting and neutralizing antibodies which proved to be protective in passive mouse protection tests and monospecifically reacted only with the viral envelope and not with the internal core. In a competitive radioimmunoassay the glycoprotein complexes revealed about 10-fold higher antigenicity than whole virus when tested at equal protein concentrations. The important implications of these results with respect to antigen quantification in vaccines are discussed. As shown in the mouse challenge potency test, glycoprotein complexes prepared after Triton X-100 solubilization actively protected mice almost as well as did complete inactivated virus at the same protein concentration, whereas those prepared after cetyltrimethylammonium bromide solubilization had a somewhat lower protective activity per microgram of protein.
Improving the performance of enzymes in hydrolysis of high solids paper pulp derived from MSW (2013)

The two-stage hydrolysis process developed could give an overall glucan conversion of 88%, with an average glucose concentration close to 8% in 4 days, thus providing an ideal starting point for ethanol fermentation with a likely yield of 4 wt%. This is a significant improvement over a single-step process. This hydrolysis configuration also provides the potential to recover the sugars associated with residual solids which are diluted when washing hydrolysed pulp.
The Dynamics of Stall and Surge Behavior in Axial-Centrifugal Compressors (1997)

The phenomena of stall and surge in axial-centrifugal compressors is investigated through high-response measurements of both the pressure field and the flowfield throughout the surge cycle. A unique high-response forward-facing and aft-facing probe provides flow information. Several axial-centrifugal compressors are examined, both in compressor rigs and engines. Extensive discussion is presented on the differences in axial and centrifugal rotors and their effect on the system response characteristics. The loading parameters of both are examined and data is presented that shows the increased tolerance of the centrifugal stage to instability. The dynamics of the compressor blade response are shown to be related to the transport time of a fluid particle moving through a blade passage. The data presented provides new insight into the dynamic interactions that occur prior to and during stall and surge. In addition, the inception of rotating stall and the inception of surge are shown to be the same phenomena . An analytical dynamic model (DYNTECC) is applied to one of the compression systems and the results are compared to data. The results show that the model can capture the global effects of rotating stall and surge. The data presented, along with the analytical results, provide useful information for the design of active and passive stall control systems.
Hybrid Diffusion: Spectral-Temporal Graph Filtering for Manifold Ranking (2018)

International audience
The AMP-Foot 3, new generation propulsive prosthetic feet with explosive motion characteristics: design and validation (2016)

The last decades, rehabilitation has become a challenging context for mechatronical engineering. From the state-of-the-art it is seen that the field of prosthetics offers very promising perspectives to roboticist. Today's prosthetic feet tend to improve amputee walking experience by delivering the necessary push-off forces while walking. Therefore, several new types of (compliant) actuators are developed in order to fulfill the torque and power requirements of a sound ankle-foot complex with minimized power consumption. At the Vrije Universiteit Brussel, the Robotics and Multibody Mechanics research group puts a lot of effort in the design and development of new bionic feet. In 2013, the Ankle Mimicking Prosthetic (AMP-) Foot 2, as a proof-of-concept, showed the advantage of using the explosive elastic actuator capable of delivering the full ankle torques ([Formula: see text] Nm) and power ([Formula: see text] W) with only a 60 W motor. In this article, the authors present the AMP-Foot 3, using an improved actuation method and using two locking mechanisms for improved energy storage during walking. The article focusses on the mechanical design of the device and validation of its working principle.
The Burden of Drug‐Resistant Tuberculosis and Mechanisms for Its Control (2001)

Drug resistance in tuberculosis is largely a man-made phenomenon caused by erroneous prescribing practices on the part of physicians and noncompliance on the part of patients. The global epidemiology of drug-resistant TB, the impact of standardized short-course chemotherapy (SSC), and the potential future evolution of MDR TB are discussed in this chapter.
Thermal and hydrolytic degradation of poly(1,4‐cyclohexylenedimethylene terephthalate) (1972)

Abstract The kinetics of simultaneous thermal and hydrolytic degradation of poly(1,4‐cyclohexylenedimethylene terephthalate) (PCHDT) were evaluated by using a 1.5‐in.‐diam. melt extruder (≈20/1 length/diameter ratio) as a reactor. The effects of extrusion temperature (295°‐330°C), residence time (2.6–17.5 min), and moisture content (<0.001% to 0.2%) of the supply polymer on degradation were determined. The rate of degradation was measured in terms of the rate at which inherent viscosity (I.V.) decreased and the rate at which carboxyl endgroup concentration increased. The contributions of both thermal and hydrolytic degradation to the total degradation of PCHDT could be separated because the hydrolysis was rapid enough that it could be considered as occurring prior to thermal degradation. Thus, the hydrolysis merely adjusted the initial properties of the supply polymer, which was then subjected to thermal degradation. Equations were developed from an analysis of the kinetic data based on a random chain scission mechanism. The activation energies for decrease in I.V. and increase in carboxyl endgroup concentration of PCHDT from thermal degradation were determined as 33.5 and 41 kcal/mole, respectively.
Repression of vascular endothelial growth factor A in glioblastoma cells using engineered zinc finger transcription factors. (2003)

Angiogenic factors are necessary for tumor proliferation and thus are attractive therapeutic targets. In this study, we have used engineered zinc finger protein (ZFP) transcription factors (TFs) to repress expression of vascular endothelial growth factor (VEGF)-A in human cancer cell lines. We create potent transcriptional repressors by fusing a designed ZFP targeted to the VEGF-A promoter with either the ligand-binding domain of thyroid hormone receptor alpha or its viral relative, vErbA. Moreover, this ZFP-vErbA repressor binds its intended target site in vivo and mediates the specific deacetylation of histones H3 and H4 at the targeted promoter, a result that emulates the natural repression mechanism of these domains. The potential therapeutic relevance of ZFP-mediated VEGF-A repression was addressed using the highly tumorigenic glioblastoma cell line U87MG. Despite the aberrant overexpression of VEGF-A in this cell line, engineered ZFP TFs were able to repress the expression of VEGF-A by >20-fold. The VEGF-A levels observed after ZFP TF-mediated repression were comparable to those of a nonangiogenic cancer line (U251MG), suggesting that the degree of repression obtained with the ZFP TF would be sufficient to suppress tumor angiogenesis. Thus, engineered ZFP TFs are shown to be potent regulators of gene expression with therapeutic promise in the treatment of disease.
Free radicals and other reactive oxygen metabolites: clinical relevance and the therapeutic efficacy of antioxidant therapy. (1993)

As in any new field, justifiable enthusiasm for the potential for antioxidant therapy has led to hyperbole, hastily designed, poorly conceived clinical trials, and premature reporting of uncontrolled, anecdotal indicators of efficacy that have not held up when subjected to close scrutiny or more careful, controlled trial design. This tendency has been augmented by strong pressure for early positive results from a few, but not most, members of the pharmaceutical industry and by a few clinicians in highly competitive fields who were anxious not to be left behind. The sobering reality of negative or, even worse, indeterminate clinical trials has culled the field and educated those that remain. As a result, we are beginning to see the publication of quite promising results from large, well-controlled, carefully designed clinical studies, many, but not all, of which are quite promising. This has been associated with a much better understanding of the basic mechanism of free radical-mediated human disease, without which further substantial progress would be quite limited. Because the manipulation of oxidant-mediated tissue injury represents treating disease at its most basic level, the therapeutic potential of this approach remains not only promising but exciting.
Metabolic effects of licorice roots (Glycyrrhiza glabra) on lipid distribution pattern, liver and renal functions of albino rats (1991)

The biochemical activity of licorice roots was investigated by administrating it to hypercholesterolaemic rats at two different doses. High cholesterol level in the serum and most organs of hypercholesterolaemic rats was accompanied by high levels of triglycerides and total lipids but low one of phospholipids. The hypocholesterolaemic action of licorice roots was accompanied by hypolipaemic action but higher level of phospholipids in the rat serum and most organs. The results showed that while the high cholesterol level in the rat serum has impairing effects on liver and renal functions, the licorice administered to these rats has a counteracting action i.e. it can improve the impaired function of both liver and p4f1ey, It has also a hypoglycaemic action.
Characterization of the Binding Interface between the E-Domain of <i>Staphylococcal</i> Protein A and an Antibody Fv-Fragment (1999)

Staphylococcal protein A (SpA) is a cell-surface component of Staphylococcus aureus. In addition to the well-characterized interaction between SpA and the Fc-region of human IgG, an alternative binding interaction between SpA and the Fab-region of immunoglobulin domains encoded by the V(H)3 gene family has been described. To characterize structurally the interface formed by SpA repeats and type-3 V(H)-domains, we have studied the 32-kDa complex formed between an E-domain mutant (EZ4) and the Fv-fragment of the humanized anti-HER2 antibody (Hu4D5-8) using heteronuclear NMR spectroscopy. Protocols were established for efficient incorporation of (15)N, (13)C, and (2)H into EZ4 and the V(H)- and V(L)-domains of the Fv, allowing backbone resonances to be assigned sequentially for EZ4 and the V(H)-domain in both free and complexed states. Broadening of certain V(H)-resonances in the free and bound Fv-fragment suggests microsecond to millisecond time-scale motion in CDR3. Residues experiencing significant chemical shift changes of backbone (1)H(N), (15)N, and (13)CO resonances upon complex formation delineate contiguous surfaces on EZ4 and the V(H)-domain that define the binding interfaces of the two proteins. The interaction surfaces identified by chemical shift mapping are comprised of predominantly hydrophilic residues. This is in contrast to the SpA-Fc interface which is predominantly hydrophobic in nature. Further analysis of the surface properties suggests a probable binding orientation for SpA- and V(H)3-domains.
Enantioselective Synthesis of (−)-Codeine and (−)-Morphine (2002)

A new synthetic strategy for the synthesis of the opiate and amaryllidaceae alkaloids emerges employing a Pd-catalyzed asymmetric allylic alkylation to set the stereochemistry. The pivotal tricyclic intermediate is available in six steps from 2-bromovanillin and the monoester of methyl 6-hydroxycyclohexene-1-carboxylate, the latter available from glutaraldehyde and the Emmons-Wadsworth-Horner phosphate reagent. This intermediate requires only two steps to convert to (-)-galanthamine. Using a Heck vinylation, we found that the fourth ring of codeine/morphine is formed. The final ring formation involves a novel visible light-promoted hydroamination. Thus, six steps are required to convert the pivotal tricyclic intermediate into codeine, which has been demethylated in high yield to morphine.
The pluripotent state in mouse and human (2015)

In the mouse, naïve pluripotent stem cells (PSCs) are thought to represent the cell culture equivalent of the late epiblast in the pre-implantation embryo, with which they share a unique defining set of features. Recent studies have focused on the identification and propagation of a similar cell state in human. Although the capture of an exact human equivalent of the mouse naïve PSC remains an elusive goal, comparative studies spurred on by this quest are lighting the path to a deeper understanding of pluripotent state regulation in early mammalian development.
Capacity With Causal and Noncausal Side Information: A Unified View (2006)

In this correspondence, we identify the common underlying form of the capacity expression that is applicable to both cases where causal or noncausal side information is made available to the transmitter. A genie-aided outerbound is developed that states that when a genie provides n bits of side information to a receiver the resulting capacity improvement cannot be more than n bits. Using the genie-bound we are able to bound the relative capacity advantage of noncausal side information over causal side information for both the single user point-to-point channel as well as the multiple-access channel (MAC) with independent side information at the transmitters. Applications of these capacity bounds are demonstrated through examples of random access channels. Interestingly, the capacity results indicate that the excessive MAC layer overheads common in present wireless systems may be avoided through coding across multiple-access blocks. It is also shown that even one bit of side information at the transmitter can result in unbounded capacity improvement
Optimal choice of FinFET devices for energy minimization in deeply-scaled technologies (2015)

FinFET devices are considered to be the device substitute for bulk CMOS in sub-20nm technology nodes due to the reduced short-channel effects, improved ON/OFF current ratio, and improved voltage scalability. This paper investigates the problem of optimal selection of deeply-scaled FinFET technology to achieve minimum energy consumption for different applications such as sensor applications, smartphones, embedded micro-processors, or server micro-processors, which differ in the required performance and duty ratio. For each application space, different FinFET technologies (with different V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sub> and gate length biases) are compared in term of minimum energy consumption for both logic circuits and cache memories. A device-circuit-architecture cross-layer framework has been developed to facilitate this technology selection. This optimal technology selection procedure demonstrates up to 11× energy saving compared to poorly selected technologies.
Reductive Cleavage of Isoxazolo[3,4-d]pyridazinones: A Synthetic Approach to Various 4,5-Functionalized 3(2H)-Pyridazinones (1991)

4-Aminopyridazin-3(2H)-ones substituted at position 5 with a variety of oxygenated carbon chains were obtained in good yields by reductive opening of the pentatomic ring of isoxazolo[3,4-d]pyridazinones (1). Starting from ethyl 4-acylisoxazole-3-carboxylates, several 4,5-functionalized 3(2H)pyridazinones (3) are obtained in a one step by treatment with the appropriate hydrazine and Pd/C
Internal Calibration on Adjacent Samples (InCAS) with Fourier Transform Mass Spectrometry (2000)

Using matrix-assisted laser desorption/ionization (MALDI) on a trapped ion mass spectrometer such as a Fourier transform mass spectrometer (FTMS) allows accumulation of ions in the cell from multiple laser shots prior to detection. If ions from separate MALDI samples are accumulated simultaneously in the cell, ions from one sample can be used to calibrate ions from the other sample. Since the ions are detected simultaneously in the cell, this is, in effect, internal calibration, but there are no selective desorption effects in the MALDI source. This method of internal calibration with adjacent samples is demonstrated here on cesium iodide clusters, peptides, oligosaccharides, poly(propylene glycol), and fullerenes and provides typical FTMS internal calibration mass accuracy of <1 ppm.
Silicone rubber edge claddings for laser disk amplifiers (1984)

We have developed a versatile and inexpensive edge cladding for disk amplifiers based on silicone rubber. Disk amplifiers require edge claddings on each laser disk to prevent feedback of amplified spontaneous emission (ASE) internal to the disks. Measurements on a 31.5-cm aperture disk amplifier indicate that single-pass ASE alone reduces stored energy by one-third at peak gain. Feedback from the disk edge allows additional passes for ASE, rapidly increasing the loss of stored energy and opening the possibility of parasitic lasing internal to the disks. Current glass edge claddings as used on Novette and Nova perform extremely well but are very expensive and must be reformulated for each different laser glass type. We plan to test several different laser glasses in large aperture disk amplifiers and, therefore, developed the rubber-based cladding to avoid the time and expense associated with several new glass claddings.