gebhart/patrepeval huggingface dataset:
The Personal Mobility and Manipulation Appliance (PerMMA): A robotic wheelchair with advanced mobility and manipulation (2012)

The Personal Mobility and Manipulation Appliance (PerMMA) is a recently developed personal assistance robot developed to provide people with disabilities and older adults enhanced assistance in both mobility and manipulation, which are two fundamental components for independently activities of daily life performing, community participation, and quality of life. Technologies to assist with mobility and manipulation are among the most important tools for clinicians, end users and caregivers; however, there are currently few systems that provide practical and coordinated assistance with mobility and manipulation tasks. The PerMMA was not only developed and evaluated to provide users and caregivers enhanced mobility and manipulation options, but also as a clinical tool as well as research platform. The development and evaluation of PerMMA are presented in the paper.
Genetic Diversity of a Maize Association Population with Restricted Phenology (2011)

Association analysis to identify genes and alleles underlying quantitative genetic variation is growing in value as the density of genotypic data increases. Association panels are often chosen to maximize molecular and phenotypic diversity, but traits measured at harvest require restricted phenology to obtain data on plants that mature within a comparable interval. The objective of this study was to characterize a set of inbred lines that will mature reliably in the upper midwestern United States for the purpose of assessing traits relevant to grain and stover yield as well as stover quality. A total of 1411 lines from the North Central Regional Plant Introduction Station, our program, and contributed by collaborators were grown in observation plots. A set of 627 lines were chosen based on flowering within the desired interval, production of viable seed, agronomic suitability, uniformity, and pedigree information. Flowering time ranged from 944 to 1645 growing degree days (GDD). Genotypic data for the 627 lines was obtained using a 1536 Illumina GoldenGate assay. The panel offers deep replication of most Midwest dent alleles. There is a lesser representation of tropical alleles relative to other association panels but includes some Germplasm Enhancement of Maize (GEM)‐derived lines and early flowering lines of tropical origin. The information described in this manuscript is anticipated to facilitate the use of this material for association genetic studies.
Recurrent Severe Infections Caused by a Novel Leukocyte Adhesion Deficiency (1992)

THE recruitment of neutrophils to sites of inflammation is initiated by the local production of bacteria-derived attractants, inflammatory cytokines, and other host-derived factors. These factors i...
Two-dimensional database of mouse liver proteins. An update (2001)

We updated the two-dimensional protein database for mouse liver. Microsomal and cytosolic fractions of the liver proteins from male mice were separated by two-dimensional electrophoresis. The proteins were identified by Matrix-assisted laser desorption/ionization-mass spectrometry (MALDI-MS) on the basis of peptide mass fingerprinting, following in-gel digestion with trypsin and matching with the theoretical peptide masses of all known proteins from all species. Approximately 5800 spots, excised from 14 two-dimensional gels, were analyzed which resulted in the identification of about 2500 proteins that were the products of 328 different genes. The database includes 112 newly identified gene products. The fractionation prior to two-dimensional electrophoresis was essential for the detection of the new proteins, 55% of which were found in the microsomal and 35% in the cytosolic fraction. The more frequently identified proteins in the various gels were heat shock proteins, house-keeping enzymes, such as ATP synthase chains, disulfide isomerase, and structural proteins, such as tropomyosin. About 45% of the identified proteins were detected 1-3 times, 45% 4-9 times, and the rest 10 or more times. Most proteins were represented by many spots. In average, about 18-20 spots were detected per gene product.
Quantitative protein analysis from formalin‐fixed tissues: implications for translational clinical research and nanoscale molecular diagnosis (2006)

Owing to its cross-linking effects, it is currently believed that formalin fixation of routinely processed tissues in the clinic prevents protein extraction and profiling. The aim of our study was to develop a robust, fast, standardized, and easy to use technique for the solubilization of non-degraded, full length, and immunoreactive proteins from formalin-fixed tissues for western blot and protein microarray analysis. Sections of routinely processed formalin-fixed and paraffin-embedded tissues of various origin were analysed. After deparaffination, tissues were manually dissected from the slides and transferred into an optimized protein extraction buffer system. Proteins were solubilized and subsequently analysed by western blot and reverse phase protein microarrays. We succeeded in isolating non-degraded, soluble, and immunoreactive proteins from routinely processed formalin-fixed tissues. We were able to detect membrane, cytoplasmic and nuclear proteins at the expected molecular weight. No differences were found in the protein yield and protein abundances between fresh frozen and formalin-fixed tissues. Using western blots and reverse phase protein microarrays, the receptor tyrosine kinase HER2, an important protein target for antibody based cancer treatment, was reliably measured in formalin-fixed breast cancer biopsy samples when compared with measurement by immunohistochemistry and fluorescence in situ hybridization; remarkably, immunohistochemically equivocal cases (score 2+) can be categorized according to HER2 protein abundance. Our new clinically orientated multiplexed protein measurement system may be generally applicable to determine the relative abundances of known disease-related proteins in small amounts of routinely processed formalin-fixed tissue samples for research and diagnosis. This technique may also be used to identify, characterize, and validate known and new protein markers in a variety of human diseases.
X-ray microscopy (1996)

Ever since W. C. Röntgen discovered his x-rays there was a desire to create a useful x-ray microscopy. The fact that the index of refraction deviates so little from that of vacuum causes, however, great difficulties in developing suitable x-ray optical elements. Quite generally, the low efficiency even of the now existing optical elements and the low brilliance of classical x-ray sources causes stringent limitations. The availability of synchrotron radiation from undulators therefore is the basis of a renewed interest in x-ray microscopy. The realization of such a microscope is achieved either by producing a magnified image of scattered or transmitted radiation or to produce a demagnified image of the source as a probe on the sample. For this purpose Fresnel zone plates, multilayer covered mirrors, and mirrors at grazing incidence are available. The resolution or the probe sizes respectively lie presently between 30 nm and 1 μm. The transmission microscope is mainly used for biological samples in aqueous solution. The scanning microscopes allow to use many different signals and this way have a strong microanalytical capacity. In the scanning microscope at HASYLAB/DESY in Hamburg a grazing incidence ellipsoid mirror is used to focus radiation in the energy range 15 eV to 1200 eV to a spot of 1 μm. The signals which are available for microscopy and microspectroscopy are transmission, photoelectrons, luminescence in the visible, UV and soft x-ray regions, scattered light and desorbed ions. Spectrometers for photoelectrons and visible/UV-luminescence are installed for secondary spectroscopies. Several of the signals are not only element specific but are also specific to the chemical environment and binding character. About 25 projects of different types are presently pursued with synchrotron radiation world-wide.
Enhanced optical coherence tomography imaging using a histogram-based denoising algorithm (2015)

A histogram-based denoising algorithm was developed to effectively reduce ghost artifact noise and enhance the quality of an optical coherence tomography (OCT) imaging system used to guide surgical instruments. The noise signal is iteratively detected by comparing the histogram of the ensemble average of all A-scans, and the ghost artifacts included in the noisy signal are removed separately from the raw signals using the polynomial curve fitting method. The devised algorithm was simulated with various noisy OCT images, and >87% of the ghost artifact noise was removed despite different locations. Our results show the feasibility of selectively and effectively removing ghost artifact noise.
CD14 signalling in lipid rafts: new ligands and co-receptors (2002)

The composition of the receptor cluster and thus the associated signalling pathways defines a ligand specific cellular response, linking endogenous and exogenous host defense to a common recognition platform in rafts.
Interturn Short-Circuit Faults in Permanent Magnet Synchronous Machines: An Extended Review and Comprehensive Analysis (2018)

This paper presents an extended review and recent advances in modeling and diagnosis of interturn short circuit (ITSC) faults in permanent magnet synchronous machines, supported with in-depth fault analysis. In the analysis part, the influence of the fault intensity on the machine's parameters and performance is analyzed at various operating conditions through finite-element analysis, drive system models, and test bench measurements. The presented findings shed light on the fault signatures and factors that are affecting signature dynamics such as the fault intensity, operating conditions, resistance of the short-circuiting path, and controller action. Following the characterization of the ITSC fault, a detailed literature review on fault signature types and state-of-the art diagnosis methods are presented. The corresponding trends, shortcomings of current solutions, and potential research topics are discussed exhaustively.
Synthesis of aza homologs of folic acid (1979)

Folic acid analogues containing an additional nitrogen atom between the phenyl ring and the carbonyl group of the side chain were synthesized. None of the compounds showed significant inhibitory activity against human lymphoblastic leukemia cells (CCRF-CEM) in culture or against Lactobacillus casei (ATCC 7469) growth. Against L1210 leukemia in mice, the aza homologue of folic acid, 4, and the aspartic acid analogue, 14, showed no increase in life span over control animals. These compounds were more toxic in vivo than the corresponding methotrexate analogues. Compound 4 supported the growth of Streptococcus faecium (ATCC 8043), and its tetrahydro derivative supported the growth of Pediococcus cerevisiae (ATCC 8081). These results strongly suggest that 4 can substitute for folate derivatives as cofactors for serine transhydroxymethylase, thymidylate synthetase, and dihydrofolate reductase.
Cardiomyoplasty Benefits in Experimental Myocardial Dysfunction (1989)

Beneficial effects of cardiomyoplasty have been documented and the use of this technique in the treatment of dilated cardiomyopathy have been suggested. This study was undertaken to evaluate the effectiveness of stimulated preconditioned latissimus dorsi muscle flaps wrapped around the heart in order to restore ventricular contractility in six adult mongrel dogs with induced myocardial dysfunction by administration of beta blockers and volume loading. Hemodynamic and two-dimensional echocardiographic evaluation were performed 1 week after the surgical procedure and immediately after heart failure induction. With synchronous pulse train electrical stimulation, cardiac output increased from 1.46 +/- 0.13 (+/- SD) to 2.01 +/- 0.16 L/min (p less than 0.01), pulmonary wedge pressure decreased from 15.5 +/- 1.2 to 11.3 +/- 1.6 mmHg (p less than 0.01) and left ventricular end-diastolic pressure from 18.3 +/- 2.4 to 13.5 +/- 1.4 mmHg (p less than 0.04). Echo derived left ventricular ejection fraction increased from 39.3 +/- 2.4 to 59.6 +/- 2.9% (p less than 0.01) and segmental wall shortening from 15.4 +/- 1.2 to 26.3 +/- 1.7% (p less than 0.01), inclusive when the muscle flap was wrapped only around the left ventricle. In conclusion, this study suggests that cardiomyoplasty may be an alternative method of treatment for irreversible cardiomyopathy, including in patients with a great cardiac enlargement in which muscle flap may only be wrapped partially around the heart.
Potential and Challenges for Mid-Infrared Sensors in Breath Diagnostics (2009)

Exhaled breath contains more than 1000 constituents at trace level concentrations, with a wide variety of these compounds potentially serving as biomarkers for specific diseases, physiologic status, or therapeutic progress. Some of the compounds in exhaled breath (EB) are well studied, and their relationship with disease pathologies is well established. However, molecularly specific analysis of such biomarkers in EB at clinically relevant levels remains an analytical and practical challenge due to the low levels of such biomarkers frequently below the ppb (v/v) range in EB. In this contribution, mid-infrared (MIR) spectroscopic sensing techniques are reviewed for potential application in breath diagnostics. While the spectral regime from 3-20 ¿m has already been utilized for fundamental studies on breath analysis, significant further improvements are in demand for substantiating MIR spectroscopy and sensing techniques as a suitable candidate for clinically deployable breath analyzers. Several advantageous features including inherent molecular selectivity, real-time monitoring capability, comparable ease of operation, potentially low costs, and a compact device footprint promise reliable optical diagnostics in the MIR. Hence, while the application of MIR spectroscopy and sensing systems to breath analysis yet appear in their infancy, recent progress on advanced MIR light sources, waveguides, and device concepts forecasts next-generation optical sensing platforms suitable for addressing the challenges of <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">in situ</i> breath diagnostics.
The ESF 2000-2006 implementation process evaluation (2003)

Restoration of sternal integrity after median sternotomy for cardiac interventions better ensures optimal postoperative pulmonary function and minimizes overall morbidity. Sternal dehiscence or nonunion mitigates against such a successful outcome. Under such circumstances, if enough viable and uninfected sternum remains, an anatomic reduction should be attempted. Rewiring usually proves unsuccessful, and rigid plate fixation is more rewarding. A new titanium sternal fixation system that permits transverse orientation of plates has been used in 4 patients who had sterile complete or imminent sternal dehiscence to allow eventual sternal union. The specific advantage of this new system is the presence of a releasing pin in the center of coupled plates to allow rapid chest reentry if required without the specific need for cumbersome plate removal. One patient had delayed removal of an infected plate after sternal union was achieved.
Inhibition of vascular endothelial cell growth by activin-A. (1993)

The demonstration of type 2 activin receptor expression in human umbilical vein endothelial cells prompted an investigation of the effects of the activin/inhibin family of hormones on vascular endothelial cell growth. Recombinant activin-A inhibited [3H]methylthymidine uptake and growth of a panel of endothelial cell types; recombinant inhibin-A was without effect. Affinity cross-linking studies demonstrated the presence of type 1 and type 2 activin receptors on the surface of bovine aortic endothelial cells, while detailed analysis of type 2 activin receptor expression revealed both type 2 and type 2B activin receptor mRNA in all endothelial cell types analyzed. In addition, capillary endothelial cells were found to express activin-beta A subunit mRNA and protein, the levels of which were increased in response to transforming growth factor (TGF)-beta. Furthermore, activin-A and TGF-beta caused additive inhibition of capillary endothelial cell [3H]methylthymidine uptake. These findings implicate the activins in the regulation of endothelial cell function, and suggest that TGF-beta and activin may interact to inhibit capillary endothelial cell growth.
Inference in two—phase regression: A simulation study with nonnormal observations (1983)

On considere le cas du modele contraint et on etudie le test de Hinkley par simulation lorsque les termes d'erreur ne sont pas normalement repartis
Conidine—Synthesis, Polymerization and Derivatives (1960)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConidine—Synthesis, Polymerization and DerivativesEdward R. Lavagnino, Robert R. Chauvette, William N. Cannon, and Edmund C. KornfeldCite this: J. Am. Chem. Soc. 1960, 82, 10, 2609–2613Publication Date (Print):May 1, 1960Publication History Published online1 May 2002Published inissue 1 May 1960https://pubs.acs.org/doi/10.1021/ja01495a054https://doi.org/10.1021/ja01495a054research-articleACS PublicationsRequest reuse permissionsArticle Views226Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Cell types, lineage, and architecture of the germinal zone in the adult dentate gyrus (2004)

New neurons continue to be born in the subgranular zone (SGZ) of the dentate gyrus in the hippocampus of adult mammals, including humans. Previous work has shown that astrocytes function as the progenitors of these new neurons through immature intermediate D cells. In the first part of the present study, we determined the structure of each of these progenitors and how they are organized in three dimensions. Serial-section reconstructions of the SGZ, using confocal and electron microscopy demonstrate that SGZ astrocytes form baskets that hold clusters of D cells, largely insulating them from the hilus. Two types of glial fibrillary acidic protein-expressing astrocytes (radial and horizontal) and three classes of doublecortin and PSA-NCAM-positive D cells (D1, D2, D3) were observed. Radial astrocytes appear to interact closely with clusters of D cells forming radial proliferative units. In the second part of this study, we show that retrovirally labeled radial astrocytes give rise to granule neurons. We also used bromodeoxyuridine and [3H]thymidine labeling to study the sequence of appearance of the different D cells after a 7-day treatment with anti-mitotics. This analysis, together with retroviral labeling data, suggest that radial astrocytes divide to generate D1 cells, which in turn divide once to form postmitotic D2 cells. D2 cells mature through a D3 stage to form new granule neurons. These observations provide a model of how the germinal zone of the adult hippocampus is organized and suggest a sequence of cellular stages in the generation of new granule neurons.
Grades of the Not So Modeled: Asian American and Pacific Islander Transfer Students at Middle University (2013)

The understanding of Asian-American and Pacific Islander (AAPI) students, beyond stereotypes, has been limited (Museus, 2009 Museus , S. D. ( 2009 ). A critical analysis of the exclusion of Asian Americans from higher education research and discourse . In L. Zhan (Ed.), Asian American voices: Engaging empowering, enabling (pp. 59 – 76 ). New York , NY : NLN Press . [Google Scholar]). Although literature on transfer students has grown, the limited research on AAPI transfer students is lacking. A more accurate portrayal of their academic progress needs to be examined. One of the ways to better understand academic progress will be to critically analyze transcripts of AAPI transfer students to better understand how they navigate through higher education. Utilizing Critical Race Theory, myth of the model minority, and transfer shock, this study will provide literature for educators to better understand the experiences and to better serve diverse students' needs. The purpose of this study was to describe the demographic and academic progress of AAPI transfer students at a large Midwest institution. Some of the results included that the graduation rates for AAPI students (native and transfer) were comparable to other students of color groups, and that AAPI transfer students experienced transfer shock.
Changes in cell surface molecules associated with in vitro culture of prostatic stromal cells (2000)

Cultured stromal cells express a number of CD molecules normally found in other cell types of the prostate. Cells can express different CD molecules under different conditions.
A double-blind comparison of levels of terbinafine and itraconazole in plasma, skin, sebum, hair and nails during and after oral medication. (1997)

No Abstract available
Failure Detection Algorithms Applied to Control System Design for Improved Diagnostics and Reliability (1988)

<div class="htmlview paragraph">This paper presents the application of detection filters to the diagnosis of sensor and actuator failures in automotive control systems.</div> <div class="htmlview paragraph">The detection filter is the embodiment of a model-based failure detection and isolation (FDI) methodology, which utilizes analytical redundancy within a dynamical system (e.g., engine/controller) to isolate the cause and location of abnormal behavior (i.e., failures).</div> <div class="htmlview paragraph">The FDI methodology has been used, among other applications, in the aerospace industry for fault diagnosis of inertial navigation systems and flight controllers. This paper presents the philosophy and essential features of FDI theory, and describes the practical application of the method to the diagnosis of faults in the throttle position sensor in an electronically controlled IC engine.</div> <div class="htmlview paragraph">The paper also discusses the incorporation of FDI systems in the design process of a control strategy, with the aim of increasing reliability by embedding diagnostic features within the control strategy.</div>