gebhart/patrepeval huggingface dataset:
Chemistry and stereochemistry of reactions of organophosphorus ligands in chiral Mo(CO)5L complexes (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemistry and stereochemistry of reactions of organophosphorus ligands in chiral Mo(CO)5L complexesLouis P. Reiff, David I. Rossman, Leonard J. Szafraniec, and Herbert S. AaronCite this: Inorg. Chem. 1986, 25, 9, 1451–1455Publication Date (Print):April 1, 1986Publication History Published online1 May 2002Published inissue 1 April 1986https://doi.org/10.1021/ic00229a030RIGHTS & PERMISSIONSArticle Views74Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (749 KB) Get e-Alertsclose Get e-Alerts
Flanking and Intragenic Sequences Regulating the Expression of the Rabbit α-Globin Gene (1995)

Despite their descent from a common ancestral gene and the requirement for coordinated, tissue-specific regulation, the alpha- and beta-globin genes in many mammals are regulated in distinctly different ways. Unlike the beta-globin gene, the rabbit alpha-globin gene is transiently expressed at a high level without an added enhancer in transfected erythroid and non-erythroid cells. By examining a series of alpha/beta fusion genes, we show that internal sequences of the rabbit alpha-globin gene (within the first two exons and introns) are required along with the 5' flank for this enhancer-independent expression. Furthermore, deletion of the introns of the alpha-globin gene, or replacement by introns of the beta-globin gene, results in severely decreased expression of the transfecting genes. Hybrid constructs between segments of the alpha-globin gene and a luciferase gene confirm that internal alpha-globin sequences are needed for high level production of RNA in transfected cells. The flanking and internal sequences implicated in regulation of the rabbit alpha-globin gene coincide with a prominent CpG-rich island and may comprise an extended promoter (including both flanking and intragenic sequences) that is active in transfected cells without an enhancer.
OLED panel defect detection using local inlier-outlier ratios and modified LBP (2015)

We present an automated system for detecting surface defects on OLED panels. These panels exhibit varying textures and patterns which complicates the defect detection process. These detection systems have to be highly accurate and reliable as even a small error in detection can cause huge losses. In this paper, we present a method for detection of OLED panel surface defects using a novel and simple set of features based on local inlier-outlier ratios and modified LBP. The proposed inlier-outlier vector is easy to compute and provides robust discrimination between defect and non-defect samples of micro defects such as scratches and spots which are missed by modified LBP, thus proving to be a good complement to the modified LBP vector. Next, we train a SVM classifier using the concatenation of inlier-outlier ratios and modified LBP features. In the experiments, we have evaluated our method on several defects like scratch, spot, stain and pit, and the results show that our method significantly outperforms methods which use only modified LBP approach with minimal increase in computational complexity.
Pyrazolo[1,5-a]pyridines as p38 Kinase Inhibitors (2005)

[reaction: see text] A convergent synthesis of substituted pyrazolo[1,5-a]pyridines has been achieved either via a regioselective [3 + 2] cycloaddition of N-aminopyridines with alkynes or by thermal cyclization of disubstituted azirines. Subsequent palladium-catalyzed introduction of pyridines or de novo synthesis of pyrimidines affords inhibitors of p38 kinase.
Selected Aspects of the Clinical Pharmacology of Visceral Analgesics and Gut Motility Modifying Drugs in the Horse (1988)

Abstarct Comparison of the visceral analgesic effects of xylazine, morphine, butorphanol, pentazocine, meperidine, dipyrone, and flunixin in a cecal distention model of colic pain indicated that xylazine produces the most relief from abdominal discomfort. Repeated administration of xylazine may reduce visceral pain so effectively that the seriousness of abdominal disease is obscured. Xylazine decreased propulsive motility in the jejunum and pelvic flexure of healthy ponies. Morphine and butorphanol also gave relief from visceral pain in the cecal distention model. Morphine may inhibit colonic, and butophanol jejunal, motility. Whether xylazine or opiate mediated decreases in gut motility cause clinically important slowing of ingesta transit is controversial and requires further investigation. The development of behavioral changes (i.e., apprehension and pawing) in horses given opiate therapy may limit the use of these drugs. Combinations of xylazine and morphine or butorphanol produce excellent, safe, visceral analgesia and sedation without untoward behavioral effects. Although flunixin fails to demonstrate good visceral analgesic effects in the cecal distention model, this drug produces analgesia in some cases of colic by blocking prostaglandin mediated induction of pain. Improvement of propulsive gut motility in patients with ileus may follow administration of neostigmine (which is particularly effective when the large bowel is hypomotile), naloxone (which experimentally stimulates propulsive colonic motility), and metoclopramide (which stimulates stomach and proximal small intestinal motility).
Raman study and theoretical calculations of strain in GaN quantum dot multilayers (2006)

Changes in strain and phonon mode energy in stacks of self-assembled GaN quantum dots embedded in AlN have been studied by means of Raman spectroscopy as a function of the number of periods. The ${E}_{2H}$ phonon modes related to the quantum dots and AlN spacers are clearly resolved, and their energies allow monitoring the state of strain of the dots and AlN spacers simultaneously. The evolution of the measured phonon frequencies and the associated strains are discussed in comparison with theoretical calculations of the inhomogeneous strain distribution in a system of coherent misfitting inclusions.
High-peak-power vertical-cavity surface-emitting laser quasi-array realized using optimized large-aperture single emitters (2014)

We report on a high-peak-power vertical-cavity surface-emitting laser (VCSEL) quasi-array emitting at approximately 980 nm. The quasi-array is composed of four tightly packaged single emitters connected in series. The external quantum efficiency of large-aperture VCSEL was improved by optimizing the current distribution, and single emitters with a 62 W peak power were developed as the basic building block of this quasi-array. More than 210 W peak power is demonstrated from a ∼2.2 × 2.2 mm2 quasi-array at a current of 110 A under 30 ns and 5 kHz pulsed operation. This is the first report on a hundreds-of-watts VCSEL module consisting of single emitters.
Whole Complement Hemolytic Activity (Ch50) Following Infusion of Stroma-Free and Polyhemoglobin Solutions in Rats (1990)

We developed a method to determine whole complement hemolytic activity (CH50) in rat plasma using a modification of the method of Mayer(1). Plasma CH50 level in 30 male Sprague Dawley rats was 1000 +/- 200 units. Following infusions with human and rat stroma-free hemoglobin or polyhemoglobin solutions, CH50 did not change significantly in rats when compared to albumin infused rats. On the other hand, CH50 significantly decreased in the group receiving membrane stroma and bacterial endotoxins.
A predictive wheel-soil interaction model for planetary rovers validated in testbeds and against MER Mars rover performance data (2006)

Successful designs of vehicles intended for operations on planetary objects outside the Earth demand, just as for terrestrial off-the-road vehicles, a careful assessment of the terrain relevant for the vehicle mission and predictions of the mobility performance to allow rational trade-off’s to be made for the choice of the locomotion concept and sizing. Principal issues driving the chassis design for rovers are the stress-strain properties of the planetary surface soil, the distribution of rocks in the terrain representing potential obstacles to movement, and the gravity level on the celestial object in question. Thus far, planetary rovers have been successfully designed and operated for missions to the Earth’s moon and to the planet Mars, including NASA’s Mars Exploration Rovers (MER’s) ‘Spirit’ and ‘Opportunity’ being in operation on Mars since their landings in January 2004.<br/><br/>Here we report on the development of a wheel-soil interaction model with application to wheel sizes and wheel loads relevant to current and near-term robotic planetary rovers, i.e. wheel diameters being between about 200 and 500 mm and vertical quasistatic wheel loads in operation of roughly 100 to 200 N. Such a model clearly is indispensable for sizings of future rovers to analyse the aspect of rover mobility concerned with motion across soils. This work is presently funded by the European Space Agency (ESA) as part of the ‘Rover Chassis Evaluation Tools’ (RCET) effort which has developed a set of S/W-implemented models for predictive mobility analysis of rovers in terms of movement on soils and across obstacles, coupled with dedicated testbeds to validate the wheel-soil models.<br/><br/>In this paper, we outline the details of the wheel-soil modelling performed within the RCET work and present comparisons of predictions of wheel performance (motion resistance, torque vs. slip and drawbar pull vs. slip) for specific test cases with the corresponding measurements performed in the RCET single wheel testbed and in the RCET system-level testbed, the latter permitting drawbar pull vs. slip measurements for complete rover development vehicles under controlled and homogeneous<br/>soil conditions. Required modifications of the wheel-soil model, in particular related to modelling the effect of wheel slip, are discussed. To strengthen the model valida1tion base, we have run single wheel measurements using a spare MER Mars rover wheel and have performed comparisons with MER actual mobility performance data, available through one of us (LR) who is a member of the MER Athena science team. Corresponding results will be presented.
Hepatocyte growth factor/c‐met promotes proliferation, suppresses apoptosis, and improves matrix metabolism in rabbit nucleus pulposus cells in vitro (2015)

The etiology of intervertebral disc (IVD) degeneration is closely related to apoptosis and extracellular matrix degradation in nucleus pulposus (NP) cells. These defects in NP cells are induced by excessive external stressors such as reactive oxygen species (ROS) and inflammatory cytokines. Recently, hepatocyte growth factor (HGF) has been shown to repair damage in various diseases through anti-apoptotic and anti-inflammatory activity. In this study, we investigated the effects of HGF on NP cell abnormality caused by ROS and inflammatory cytokines by using primary NP cells isolated from rabbit IVD. HGF significantly enhanced the proliferation of NP cells. Apoptosis of NP cells induced by H2 O2 or TNF-α was significantly inhibited by HGF. Induction of mRNA expression of the inflammation mediators cyclooxygenase-2 and matrix metalloproteinase-3 and -9 by TNF-α was significantly suppressed by HGF treatment. Expression of c-Met, a specific receptor for HGF, was confirmed in NP cells and was increased by TNF-α, suggesting that inflammatory cytokines increase sensitivity to HGF. These findings demonstrate that activation of HGF/c-Met signaling suppresses damage caused by ROS and inflammation in NP cells through multiple pathways. We further suggest the clinical potential of HGF for counteracting IVD degradation involved in NP cell abnormalities.
Prognosis of COVID-19: Changes in laboratory parameters. (2020)

More studies are warranted to further objectively confirm the clinical value of prognostic factors related to SARS-CoV 2 and establish an easy-to-get panel of laboratory findings for evaluating the disease severity.
Properties of Two Clostridia Strains Acting as Catalysts for the Preparative Stereospecifïc Hydrogenation of 2-Enoic Acids and 2-Alken-1-ols with Hydrogen Gas (1978)

A Clostridium strain growing on crotonate/hydrogencarbonate, which is able to hydrogenate stereospecifically 2-enoates as well as other unsaturated compounds with hydrogen gas, has been isolated and methods for its propagation elucidated. For this strain and for Clostridium kluyveri DSM 555 grown on ethanol/acetate/hydrogencarbonate, samples of 200-l batches were assayed to determine the hydrogenation activity for (E)-2-methyl-2-butenoate and (E)-2-buten-1-ol as a function of time during the exponential and stationary growth phases. For the strain growing on crotonate/hydrogencarbonate, the hydrogenation rate as a function of substrate concentration, pH and temperature has been measured. Storage conditions for both strains are given.
Suspended substrate strip line filters with flat delay (2003)

A procedure has been developed for designing narrowband suspended substrate stripline (SSS) microwave filters in the comb form. The design is based on an even-degree lowpass lumped prototype network of a ladder nature. An auxiliary coupling has been introduced to flatten the delay characteristics. A frequency transformation has been worked out to transform the characteristics of the lumped filter to the microwave region. Explicit formulas have been derived for physical dimensions of the SSS lines from the relationships between the characteristic admittance and the static capacitances of the lines and the element values of the prototype network.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Reducing Hemoglobin Oxygen Affinity Does Not Increase Hydroxyl Radicals After Acute Subdural Hematoma in the Rat (1999)

Extensive evidence is available to show the importance of ischemia after severe human head injury. We have previously shown that pharmacologically increasing the release of oxygen in brain tissue where the local oxygen pressure is low reduces infarct size in animal models. To study the possible negative effects of this strategy, we tested the effect of an allosteric modifier of hemoglobin (RSR13) on free radical production in the rat acute subdural hematoma (ASDH) model, both under normoxic as well as under hyperoxic, normobaric conditions. When compared to baseline, induction of ASDH resulted in a significant increase (p < 0.05) in 2,3-DHBA (2,3 dihydroxybenzoic acid, produced from salicylate after attack by hydroxyl radicals) at 30 and 60 min postinduction, both for the control group (39% and 91%) as well as the RSR13-treated group (41% and 62%). The 2,5-DHBA also increased significantly (p < 0.05) in the drug-treated animals at the 30- and 60-min time points when compared to baseline (49% and 77%). At all time points, except the 30-min, the increase in 2,3-DHBA was less marked in the RSR13 animals than in the control group. Similarly, the 2,5-DHBA increase after ASDH was lower at all time points except for the 30-min time point in the RSR13-treated group. These results indicate that enhanced tissue oxygen release by the allosteric modifier of hemoglobin RSR13 does not increase hydroxyl radical production after ASDH. Clinical trials are needed to test this compound in humans after severe head injury.
Integration of vision modules and labeling of surface discontinuities (1989)

It is assumed that a major goal of the early vision modules and their integration is to deliver a cartoon of the discontinuities in the scene and to label them in terms of their physical origin. The output of each of the vision modules is noisy, possibly sparse, and sometimes not unique. The authors suggest the use of a coupled Markov random field (MRF) at the output of each module (image cues)-stereo, motion, color, and texture-to achieve two goals: first, to counteract the noise and fill in sparse data, and secondly, to integrate the image within each MRF to find the module discontinuities and align them with the intensity edges. The authors outline a theory of how to label the discontinuities in terms of depth, orientation, albedo, illumination, and specular discontinuities. They present labeling results using a simple linear classifier operating on the output of the MRF associated with each vision module and coupled to the image data. The classifier has been trained on a small set of a mixture of synthetic and real data.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Angiotensin-converting enzyme inhibitor-induced renal failure (1990)

Angiotensin-converting enzyme inhibitor-induced renal failure is now a well-recognized phenomenon that appears to occur almost exclusively in patients with a preexisting reduction in renal perfusion pressure, especially those with renovascular disease. In the latter group of patients, renal failure probably results from some combination of reduced poststenotic renal perfusion pressure and a unique disturbance in the autoregulation of glomerular filtration rate. Although traditionally regarded as functional and reversible, recent animal studies suggest that angiotensin-converting enzyme inhibitor-induced reductions of glomerular filtration rate may lead to progressive renal atrophy, an observation that raises concerns about the long-term safety of these agents in patients with renovascular disease. On the other hand, the deleterious consequences of angiotensin-converting enzyme inhibition in renovascular disease have been exploited as aids in the diagnosis of this disorder. Whether the adjunctive use of angiotensin-converting enzyme inhibitors will prove to be useful in screening large populations of hypertensive patients for renovascular hypertension remains to be determined. However, such adjunctive tests appear to be useful in judging the functional significance of angiographically documented renal artery stenosis.
Parametric thermal modeling of 3D stacked chip electronics with interleaved solid heat spreaders (2006)

Effective methods must be devised to transfer the heat from the core of 3D stacked chip electronics to the exterior of the device. The use of solid heat spreaders of high thermal conductivity interleaved between the chips was investigated parametrically through computational modeling. The effect of the power dissipated, the applied heat transfer coefficient, the spreader thickness, spreader thermal conductivity, and the shape of via holes in the spreader were modeled. Results show that for moderate power dissipations, 5 W in each 27 times 38 mm layer, a 250 mum thick copper heat spreader would conduct heat adequately
Synthesis, structures, and acute toxicity of gossypol nonsymmetrical aldehyde derivatives (2010)

Nonsymmetrical aldehyde derivatives of gossypol, a yellow polyphenolic pigment of cottonseed, were synthesized by reactions with ammonia, aniline, 4-aminoantipyrine, and barbituric acid. Their structures were determined by UV spectrophotometry and IR and (1)H NMR spectroscopy methods. Their acute toxicities in white mice were compared with those of gossypol and the corresponding symmetrical analogues. It was demonstrated that in general, the fewer free aldehyde groups that contained the gossypol derivative, the lower its acute toxicity. Only in the case of a nonsymmetrical gossypol derivative bearing a 4-aminoantipyrine residue did we observe a deviation from the above correlation: its symmetrical counterpart was even more toxic, but still less toxic than gossypol.
New Risk Markers in Atrial Fibrillation (2013)

Atrial fibrillation (AF) confers an independent increased risk of stroke and death. The stroke risk is very heterogeneous and current risk stratification models based on clinical variables, such as the CHADS2 and CHA2DS2VASc score, only offer a modest discriminating value. The aims of this thesis were to study cardiac biomarkers, cardiac troponin and natriuretic peptides e.g. N-terminal prohormone-B-type natriuretic peptide (NT-proBNP), and describe levels in AF patients, investigate the association with stroke or systemic embolism, cardiovascular event, major bleeding and mortality, and to assess how levels of cardiac biomarkers change over time. Cardiac troponin was analyzed with contemporary assays and high sensitivity assays. The study populations consisted of patients with atrial fibrillation and one risk factor for stroke included in the RE-LY (n=6189) and the ARISTOTLE (n=14892) biomarker substudies. Median follow-up time was 2.2 years and 1.9 years, respectively. In a subset of participants (n=2514) data from repeated measurements was available at three months. Cardiac troponin was detectable in 57.0% with the contemporary assay and 99.4% with the high sensitivity assay. NT-proBNP was elevated in approximately three quarters of the participants. In Cox models adjusted for established risk factors the cardiac biomarkers levels was independently associated with stroke or systemic embolism, cardiovascular events, and mortality. Only cardiac troponin was associated with major bleeding. In ROC analyses the prediction of stroke or systemic embolism, cardiovascular events, and mortality increased significantly by addition of cardiac troponin or NT-proBNP to the models. Persistent detectable cardiac troponin (contemporary assay) and elevated NT-proBNP levels were found in a large number of participants. Persistent detectable or elevated levels conferred significantly higher risk for stroke or systemic embolism, cardiovascular events, and mortality. By using both cardiac biomarkers simultaneously the risk stratification improved even further for all outcomes. In conclusion the analyses for the first time display that elevation of troponin I and NT-proBNP are common in patients with AF and independently related to increased risks of stroke, cardiovascular events and mortality. Persistent elevation of troponin and NT-proBNP indicate a worse prognosis than transient elevations or no elevations of either marker. The cardiac biomarkers added substantial improvements to existing risk stratification models.
Response Surface Model for Anesthetic Drug Interactions (2000)

Response surfaces can describe anesthetic interactions, even those between agonists, partial agonists, competitive antagonists, and inverse agonists. Application of response-surface methodology permits characterization of the full concentration-response relation and therefore can be used to develop practical guidelines for optimal drug dosing.
Controlled resonant converters with switching frequency fixed (1987)

This paper presents a method to regulate the output voltage of resonant DC-DC converter without changing switching frequency. It is based on the concept of changing resonant frequency by using either a variable inductance circuit or a variable capacitance, which is controlled auxiliary switches. The switching loss of the auxiliary switch is minimized due to no intersection between the voltage and the current. A 1-MHz, 50W breadboard regulator of Class-E converter has been built which shows high efficiency of 93.7%.