gebhart/patrepeval huggingface dataset:
Intracellular amyloid beta interacts with SOD1 and impairs the enzymatic activity of SOD1: implications for the pathogenesis of amyotrophic lateral sclerosis (2009)

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease caused by the degeneration of motor neurons. Mutations in Cu/Zn superoxide dismutase (SOD1), including G93A, were reportedly linked to familial ALS. SOD1 is a key antioxidant enzyme, and is also one of the major targets for oxidative damage in the brains of patients suffering from Alzheimers disease (AD). Several lines of evidence suggest that intracellular amyloid beta (Abeta) is associated with the pathogenesis of AD. In this report we demonstrate that intracellular Abeta directly interacts with SOD1, and that this interaction decreases the enzymatic activity of the enzyme. We observed Abeta-SOD1 aggregates in the perinuclear region of H4 cells, and mapped the SOD1 binding region to Abeta amino acids 26-42. Interestingly, intracellular Ab binds to the SOD1 G93A mutant with greater affinity than to wild-type SOD1. This resulted in considerably less mutant enzymatic activity. Our study implicates a potential role for Abeta in the development of ALS by interacting with the SOD1 G93A mutant.
Interactive analysis and quality assessment of single-cell copy-number variations (2014)

We present an open-source visual-analytics web platform, Ginkgo ( http://qb.cshl.edu/ginkgo ), for the interactive analysis and quality assessment of single-cell copy-number alterations. Ginkgo automatically constructs copy-number profiles of individual cells from mapped reads, as well as constructing phylogenetic trees of related cells. We validate Ginkgo by reproducing the results of five major studies and examine the data characteristics of three commonly used single-cell amplification techniques to conclude DOP-PCR to be the most consistent for CNV analysis.
Framework for DC Network Virtualization (2012)

Several IETF drafts relate to the use of overlay networks to support
large scale virtual data centers. This draft provides a framework for
Network Virtualization over L3 (NVO3) and is intended to help plan a
set of work items in order to provide a complete solution set. It
defines a logical view of the main components with the intention of
streamlining the terminology and focusing the solution set.
Antibody Formation to Trehalose-6, 6′-Dimycolate (Cord Factor) of <i>Mycobacterium tuberculosis</i> (1972)

A complex of trehalose-6, 6'-dimycolate (cord factor) and methylated bovine serum albumin was prepared, and its effect on the toxicity of cord factor in mice was studied. Either the active immunization with cord factor-methylated bovine serum albumin complex or the passive transfer of sera of rabbits vaccinated with the complex protected mice against the toxic action of cord factor. The antisera of mice and rabbits and gamma globulin fraction of rabbit antiserum demonstrated a precipitin reaction with an aqueous emulsion of cord factor. The reactivity of anticord factor was totally lost by treatment with 2-mercaptoethanol. The antigenic determinant group of cord factor was alpha-d-trehalose. Cord factor-anticord factor complex was devoid of activity to induce in vitro swelling and inhibition of respiratory and phosphorylative activity of mouse liver mitochondria. These results suggest that vaccination with cord factor-methylated bovine serum albumin complex induced the production of antibody to cord factor in mouse and rabbit serum which binds to cord factor and neutralizes its toxic activity either in vivo or in vitro.
Multilayer Graphene Enables Higher Efficiency in Improving Thermal Conductivities of Graphene/Epoxy Composites (2016)

The effects of number of graphene layers (n) and size of multilayer graphene sheets on thermal conductivities (TCs) of their epoxy composites are investigated. Molecular dynamics simulations show that the in-plane TCs of graphene sheets and the TCs across the graphene/epoxy interface simultaneously increase with increasing n. However, such higher TCs of multilayer graphene sheets will not translate into higher TCs of bulk composites unless they have large lateral sizes to maintain their aspect ratios comparable to the monolayer counterparts. The benefits of using large, multilayer graphene sheets are confirmed by experiments, showing that the composites made from graphite nanoplatelets (n > 10) with over 30 μm in diameter deliver a TC of ∼1.5 W m(-1) K(-1) at only 2.8 vol %, consistently higher than those containing monolayer or few-layer graphene at the same graphene loading. Our findings offer a guideline to use cost-effective multilayer graphene as conductive fillers for various thermal management applications.
Recent advances in the diagnosis and management of epilepsy. (2001)

Epilepsy is the second most common neurological disorder in developed countries. Recent advances in the understanding of pathogenetic mechanisms and in the diagnosis and management of epilepsy over the past decade have had a significant impact on every aspect of epilepsy management. A simple diagnosis is inadequate for both patients and physicians. A full diagnostic investigation to classify the type of epilepsy is now mandatory for appropriate care. In this review, current views on pathogenetic mechanisms, controversies in classification, advances in neuroimaging techniques, the use of novel antiepileptic drugs, and non-pharmacological treatment options for intractable epilepsy will be discussed.
SCHIZOPHRENIA AND POLYMORPHIC CAG REPEATS ARRAY OF CALCIUM-ACTIVATED POTASSIUM CHANNEL (<i>KCNN3</i>) GENE IN SERBIAN POPULATION (2006)

KCNN3 might be a candidate gene for schizophrenia. The KCNN3 cDNA sequence contains two stretches of CAG trinucleotide repeats encoding two separate polyglutamine segments near the N-terminus of this channel protein. The second CAG repeat is highly polymorphic in the Caucasian population from both Europe and United States. The authors carried out a study to compare the allelic frequency distribution of the CAG repeat in KCNN3 gene in 55 Serbian schizophrenic patients and 46 controls. The data indicate a significant association between longer CAG repeats in second polymorphic KCNN3 region and schizophrenia in the Serbian population.
Spatially uniform single-qubit gate operations with near-field microwaves and composite pulse compensation (2013)

We present a microfabricated surface-electrode ion trap with a pair of integrated waveguides that generate a standing microwave field resonant with the 171Yb+ hyperfine qubit. The waveguides are engineered to position the wave antinode near the center of the trap, resulting in maximum field amplitude and uniformity along the trap axis. By calibrating the relative amplitudes and phases of the waveguide currents, we can control the polarization of the microwave field to reduce off-resonant coupling to undesired Zeeman sublevels. We demonstrate single-qubit pi-rotations as fast as 1 us with less than 6 % variation in Rabi frequency over an 800 um microwave interaction region. Fully compensating pulse sequences further improve the uniformity of X-gates across this interaction region.
Spectral Design in Markov Random Fields (2011)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Jiao Wang, Jean‐Baptiste Thibault, Zhou Yu, Ken Sauer, Charles Bouman; Spectral Design in Markov Random Fields. AIP Conf. Proc. 14 March 2011; 1305 (1): 451–458. https://doi.org/10.1063/1.3573652 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Latent Iron in Silicon (2001)

It is usually assumed that the iron in iron-contaminated, boron-doped silicon exists as FeB pairs. The iron can be cycled between its interstitial (Fe i ) and paired (FeB) states with the total density Fe i +FeB remaining constant. We have discovered that iron can also exist in other paired states, which we believe to be Fe-vacancy or Fe-implant damage pairs. When these pairs are destroyed and subsequently when FeB pairs form, we have observed an increased density. We refer to the excess iron (ΔFeB) after re-formation as “latent” iron.
Import of Distributed Parameter Models into Lumped Parameter Model Libraries for the Example of Linearly Deformable Solid Bodies (2010)

Modelling of heterogeneous systems is always a trade-off between model complexity and accuracy. Most libraries of object-oriented, equation-based, multi-physical simulation tools are based on lumped parameter description models. However, there are different ways of including spatial dependency of certain variables in the model. One way that might be quite difficult is to manually discretize the model into an interconnection of lumped parameter models. This approach can get very time-consuming and is always sensitive to modelling or identification errors. To avoid these issues, we try to take advantage of the well-established methods for automatically discretizing a distributed parameter model for example by means of Finite Element methods. However, to achieve a suffiently good approximation, these methods very often result in large-scale dynamic systems that can not be handled within equation-based simulators. To overcome this drawback there exist different approaches within the literature. On the basis of deformable mechanical structures, one way of including distributed parameter models into libraries of lumped parameter models for the purpose of common simulation is pointed out in the present paper. For the implementation of the resulting models the authors take advantage of equation-based modelling libraries as new models can here easily be integrated.
Information dissemination in multihop inter-vehicle networks (2003)

In addition to the integration of vehicles into traditional networks (e.g. access to the Internet via cellular) the Ad-hoc connection of vehicles within a limited area is a technology that promises a lot of innovative and exciting services. This paper starts with the description of some services to motivate Ad-hoc networking in the vehicular environment. It then gives an overview of the current challenges (especially routing protocols) in this field. If the geographic position of the network nodes is known, better performance can be achieved with the utilization of so called geocast routing-algorithms. An overview of geocast-routing is given and shortcomings of the existing protocols for the usage in inter-vehicle Ad-hoc networks are explained. Finally we make a proposal for a vehicle-optimized geocast routing, protocol that is based on AODV and present our prototype implementation.
Versatile Production of Poly(Epsilon-Caprolactone) Fibers by Electrospinning Using Benign Solvents (2016)

The electrospinning technique is widely used for the fabrication of micro- and nanofibrous structures. Recent studies have focused on the use of less toxic and harmful solvents (benign solvents) for electrospinning, even if those solvents usually require an accurate and longer process of optimization. The aim of the present work is to demonstrate the versatility of the use of benign solvents, like acetic acid and formic acid, for the fabrication of microfibrous and nanofibrous electrospun poly(epsilon-caprolactone) mats. The solvent systems were also shown to be suitable for the fabrication of electrospun structures with macroporosity, as well as for the fabrication of composite electrospun mats, fabricated by the addition of bioactive glass (45S5 composition) particles in the polymeric solution.
Dose-Range Study of a New Calcium Sensitizer, Levosimendan, in Patients with Left Ventricular Dysfunction (1995)

Levosimendan, a new drug that sensitizes troponin-C to calcium and selectively inhibits phosphodiesterase III, was administered to 24 patients with ischemic heart disease and ejection fraction below 40%.In a placebo-controlled, crossover, double-blind study, each patient received two intravenous doses of levosimendan on 2 consecutive study days. The doses were 0.25 mg (n = 6), 0.5 mg(n = 11), 1 mg(n = 12), 2 mg(n = 12), and 4 mg (n = 5). After 0.25 mg and 0.5 mg, cardiac output increased by 0.49–0.67 L/min (p < 0.05) due to an increase in stroke volume of 6–11 ml. After 2 and 4 mg, cardiac output increased by 0.61–0.88 L/min due to an increase in heart rate of 6–12 beats/min. The baseline filling pressures, i.e., right atrial pressure (RAP) and pulmonary capillary wedge pressure (PCWP), were within the normal range. RAP decreased significantly (p < 0.05) after 2 and 4 mg and PCWP after 0.5, 1, 2, and 4 mg. The most profound decreases were observed 10 min after infusion of 4 mg, from 5.0 to 3.2 mm Hg in RAP and from 9.8 to 6.0 mm Hg in PCWP. Total peripheral resistance decreased significantly only after 2 and 4 mg, by 13 and 21%, respectively. However, there were no statistically significant changes in pulmonary vascular resistance. It is concluded that levosimendan has a hemodynamically favorable action after 0.25 and 0.5 mg but that decreases in tilling pressures probably prevented the increase in stroke volume and caused a reflex increase in heart rate after 2 and 4 mg.
A Cancelable Iris- and Steganography-Based User Authentication System for the Internet of Things (2019)

Remote user authentication for Internet of Things (IoT) devices is critical to IoT security, as it helps prevent unauthorized access to IoT networks. Biometrics is an appealing authentication technique due to its advantages over traditional password-based authentication. However, the protection of biometric data itself is also important, as original biometric data cannot be replaced or reissued if compromised. In this paper, we propose a cancelable iris- and steganography-based user authentication system to provide user authentication and secure the original iris data. Most of the existing cancelable iris biometric systems need a user-specific key to guide feature transformation, e.g., permutation or random projection, which is also known as key-dependent transformation. One issue associated with key-dependent transformations is that if the user-specific key is compromised, some useful information can be leaked and exploited by adversaries to restore the original iris feature data. To mitigate this risk, the proposed scheme enhances system security by integrating an effective information-hiding technique-steganography. By concealing the user-specific key, the threat of key exposure-related attacks, e.g., attacks via record multiplicity, can be defused, thus heightening the overall system security and complementing the protection offered by cancelable biometric techniques.
Integration of transcriptomics and metabolomics for understanding of global responses to nutritional stresses in <i>Arabidopsis thaliana</i> (2004)

Plant metabolism is a complex set of processes that produce a wide diversity of foods, woods, and medicines. With the genome sequences of Arabidopsis and rice in hands, postgenomics studies integrating all "omics" sciences can depict precise pictures of a whole-cellular process. Here, we present, to our knowledge, the first report of investigation for gene-to-metabolite networks regulating sulfur and nitrogen nutrition and secondary metabolism in Arabidopsis, with integration of metabolomics and transcriptomics. Transcriptome and metabolome analyses were carried out, respectively, with DNA macroarray and several chemical analytical methods, including ultra high-resolution Fourier transform-ion cyclotron MS. Mathematical analyses, including principal component analysis and batch-learning self-organizing map analysis of transcriptome and metabolome data suggested the presence of general responses to sulfur and nitrogen deficiencies. In addition, specific responses to either sulfur or nitrogen deficiency were observed in several metabolic pathways: in particular, the genes and metabolites involved in glucosinolate metabolism were shown to be coordinately modulated. Understanding such gene-to-metabolite networks in primary and secondary metabolism through integration of transcriptomics and metabolomics can lead to identification of gene function and subsequent improvement of production of useful compounds in plants.
Addiction: part II. Identification and management of the drug-seeking patient. (2000)

The medications most often implicated in prescription drug abuse are opioid analgesics, sedative-hypnotics and stimulants. Patients with acute or chronic pain, anxiety disorders and attention-deficit disorder are at increased risk of addiction comorbidity. It is important to ask patients about their substance-use history, including alcohol, illicit drugs and prescription drugs. Patients who abuse prescription drugs may exhibit certain patterns, such as escalating use, drug-seeking behavior and doctor shopping. A basic clinical survival skill in situations in which patients exert pressure on the physician to obtain a prescription drug is to say "no" and stick with it. Physicians who overprescribe can be characterized by the four "Ds"-dated, duped, dishonest and disabled. Maintaining a current knowledge base, documenting the decisions that guide the treatment process and seeking consultation are important risk-management strategies that improve clinical care and outcomes.
Effects of particle size and active ingredient content on residual activity of chlorpyrifos wettable powder formulations against codling moth, <i>Cydia pomonella</i> (L.) (1977)

Abstract In a laboratory experiment Cydia pomonella (L.) eggs, two days from eclosion, were placed on apples which had been sprayed five weeks previously with chlorpyrifos (125 mg/litre) from five formulations. Four were wettable powders (250 g a.i./kg) with particles ca 4, 5, 9 and 10 μm in diameter and one (500 g a.i./kg) with particles 2 μm in diameter. The treated apples were aged in direct sunlight. The percentage of apples without deep entries by first instar larvae one week after positioning of eggs, was greater the greater the ratio of active ingredient content of a formulation to total wettable powder particle surface area.
Radio system design for broadband residential access (2003)

This paper reviews the requirements and design for a low cost residential broadband wireless access system for use in the MM-wave bands (24-42 GHz). The proposed system design is based on a downlink utilizing time division multiplexing and packet transmission using the MCNS DOCSIS standard. In the upstream direction time division multiple access is used for data packet bursts also following the MCNS DOCSIS standard. These choices are made to suit the radio propagation environment and to assure low cost of the subscriber equipment.
Two Types of Oxidative Dimerization of the Black Tea Polyphenol Theaflavin (2001)

Theaflavin and its galloyl esters are polyphenolic pigments of black tea. In the course of studies on the oxidation mechanism of tea polyphenols, two theaflavin oxidation products named bistheaflavins A and B were isolated, and their structures were elucidated on the basis of MS and NMR spectroscopic analyses. Treatment of a mixture of (-)-epicatechin and (-)-epigallocatechin with banana fruit homogenate yielded bistheaflavin A together with theaflavin and theanaphthoquinone. The symmetrical structure of bistheaflavin A suggested that this compound was formed by oxidative C [bond] C coupling of two theaflavin molecules. In contrast, theaflavin in phosphate buffer (pH 7.3) was gradually oxidized to give bistheaflavin B and theanaphthoquinone. Bistheaflavin B possesses a bicyclooctane skeleton probably formed by intermolecular cyclization between dehydrotheaflavin and dihydrotheanaphthoquinone.
A design approach for actively shielded magnetic resonance imaging magnets (1990)

A design basis for an actively shielded arrangement of coils is presented which results in an optimized magnet configuration suitable for magnetic resonance imaging (MRI). A random search technique is used to select configurations using the least amount of conductor, exhibiting the smallest level of field inhomogeneity, and resulting in the least level of stray field while meeting central field and size requirements. A computer program has been developed which incorporates this design approach. Magnetic configurations selected with the aid of this design tool are discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Numerical Ranges for Partial Matrices (1991)

The field of values (or numerical range) is an important notion in the generalization of facts about Hermitian matrices to general complex matrices. Completions of partial Hermitian matrices have now been studied in some depth, and it is time to study completions of more general complex partial matrices. Two natural definitions for the “field of values” of a square partial complex are suggested. The first “builds up” from the inside of any completion, or a specification of the free entries, of a given partial matrix, while the second “whittles down” from the classical field of values of any completion. In general, the resulting sets are different, though there is a universal containment. In this note we characterize those patterns of specified entries for which the two definitions are identical. Chordal graphs again play a key role, but in a somewhat different way from the classical positive definite Hermitian case.
Knockdown of Midgut Genes by dsRNA-Transgenic Plant-Mediated RNA Interference in the Hemipteran Insect Nilaparvata lugens (2011)

Our study shows that genes for the RNAi pathway (Nlsid-1 and Nlaub) are present in N. lugens. When insects were fed on rice plant materials expressing dsRNAs, RNA interference was triggered and the target genes transcript levels were suppressed. The gene knockdown technique described here may prove to be a valuable tool for further investigations in N. lugens. The results demonstrate the potential of dsRNA-mediated RNAi for field-level control of planthoppers, but appropriate target genes must be selected when designing the dsRNA-transgenic plants.
Determination of the Optimal Ammonium Sulfate Concentration for the Fractionation of Rabbit, Sheep, Horse, and Goat Antisera (1973)

Various ammonium sulfate concentrations and reaction conditions were employed in the fractionation of sera from rabbits, sheep, horses, and goats. Precipitates and supernatant fluids were analyzed by electrophoresis to study the effects of the controlled variables. At room temperature, the third precipitate in 35% saturated (NH(4))(2)SO(4) was the best fraction from both rabbit and sheep sera; 80 to 90% of the gamma globulins were recovered. The second and third precipitates of horse sera proteins in 30% saturated (NH(4))(2)SO(4) were both satisfactory, but only 44% of the gamma globulin was recovered after three precipitations. Goat sera yielded a very satisfactory fraction; 80% of the gamma globulin was recovered after two precipitations-the first in 30% and the second in 45% saturated (NH(4))(2)SO(4). The composition of these fractions was not influenced by the pH of the sulfate solutions (pH 5.8 and 7.2), by a range of normal room temperatures (20 to 30 C), or by diluting the sera before fractionation. Crude globulins and fluorescein isothiocyanate-labeled globulins were successfully refractionated by one precipitation in the optimal sulfate concentration for the appropriate animal species. The refractionated products contained considerably less beta and alpha globulins than did the original crude fractions and little or no albumin.