gebhart/patrepeval huggingface dataset:
Relaxation Behavior of the Freely Jointed Chain (1970)

A method is presented for treating the relaxation behavior of the freely jointed chain model of a random coil polymer. Exact results are exhibited for the relaxation of quantities linear in chain coordinates. For the treatment of quantities quadratic in chain coordinates, a numerical approach is employed and exemplified by obtaining the autocorrelation in the square of end-to-end length for chains of up to 16 beads. In both cases, the rapid approach of the behavior of the freely jointed chain of N beads to that of the Rouse model of N statistical segments is demonstrated.
Assessment of Endothelial Function in the Radial Artery Using Inhaled Albuterol (2007)

Endothelial dysfunction is an early indicator of developing atherosclerosis and is a strong predictor of future heart attack and stroke. At present, evaluation of endothelial function (EF) (specifically, EF mediated by nitric oxide, NO) is too technically difficult to form part of a routine clinical examination. Non-invasive methods that measure NO-dependent EF in arteries make use of a 4-5 minute blood pressure cuff occlusion of the arm in order to induce reactive hyperemia (RH) upon cuff release. The increased blood flow that results from the RH stimulates the endothelial cells to release NO and relax the surrounding vascular smooth muscle. The magnitude of the change in arterial caliber or stiffness provides a measure of EF. The cuff occlusion is uncomfortable and inflation and release inevitably move the arm, increasing the technical difficulty of obtaining reliable measurements. In beta2-adrengergic agonist albuterol induces NO-mediated vasorelaxation in resistance vessels of humans. We examine, for the first time, the effect of albuterol on conduit vessels (radial artery) by measuring changes in the transit times of artificial pulses observed after inhalation of albuterol. We conclude that albuterol is able to relax the radial artery and that this correlates with the effects of RH (r=0.62, p=0.04). However, the response to a dose of 360 micro-g is smaller and more variable when compared to the response to RH-based stimulus.
On-line data acquisition system for acoustic emission signals (1980)

An electronic system for processing and recording some very important parameters of acoustic emission signals at a relatively high speed is described. The system is applicable to almost any process in which acoustic emission is implemented for quality control. Data processing is done in real time. The processed data are ring-down count (threshold crossing), energy, duration, and time of occurrence of each acoustic emission burst.
Synthesis and Evaluation of Difluorophosphate Salt Electrolyte Additives for Lithium-Ion Batteries (2020)

The electrolyte additive lithium difluorophosphate improves the lifetime of lithium-ion cells. This work presents the synthesis and evaluation of alternative difluorophosphate salt electrolyte additives. Ammonium difluorophosphate is readily prepared via a solid-state, benchtop reaction of ammonium fluoride and phosphorus pentoxide that requires only gentle heating to initiate. The best yield of sodium difluorophosphate (NaFO) in the present study was obtained by reacting difluorophosphoric acid and sodium carbonate in 1,2-diemethoxyethane over 3 Å molecular sieves. Tetramethylammonium difluorophosphate was prepared from NaFO via cation-exchange with tetramethylammonium chloride. NaFO is here reported to be a very good electrolyte additive, with similar performance in NMC532/graphite pouch cells as the lithium salt. The beneficial nature of both additives is attributable to the difluorophosphate anion. In contrast, ammonium and tetramethylammonium difluorophosphates are found to be poor electrolyte additives. For the former, this is suggested to be due to the formation of lithium nitride and hydrogen gas.
Jasmonates and Na‐orthovanadate promote resveratrol production in <i>Vitis vinifera</i> cv. Barbera cell cultures (2005)

Here the effect of jasmonic acid, methyljasmonate and Na-orthovanadate on the production of resveratrol was studied in Vitis vinifera cv. Barbera cell suspension cultures. Na-orthovanadate at 0.1 mm and 1 mm concentration was efficient in promoting the production and/or accumulation and release in the culture medium of cis-resveratrol while trans-resveratrol levels were not affected by this treatment. Methyljasmonate was highly effective in stimulating both trans- and cis-resveratrol endogenous accumulation, as well as their release into the culture medium. Cis-resveratrol was absent or detected in very low amounts in the controls. Jasmonic acid was less efficient than methyljasmonate in promoting endogenous resveratrol accumulation, but it stimulated the release in the culture medium especially of cis-resveratrol. Gel analysis was performed on control and 10 microm MeJA treated cell suspensions. Results showed an up-regulation of the stilbene synthase demonstrating that MeJA stimulated the synthesis ex-novo of this protein.
Nitroprusside stimulates mitochondrial aconitase gene expression through the cyclic adenosine 3′,5′‐monosphosphate signal transduction pathway in human prostate carcinoma cells (2004)

These results establish the function of nitroprusside as a signaling molecule for mACON gene expression through the cAMP signal transduction pathway in human prostatic carcinoma cells.
Detecting single-feature polymorphisms using oligonucleotide arrays and robustified projection pursuit (2005)

http://faculty.ucr.edu/~xpcui.
Precoding of orthogonal STBC with channel covariance feedback for minimum error probability (2005)

This paper develops the linear transformation (or precoding) of orthogonal space-time block codes (STBC) for minimizing probability of decoding error, when the channel covariance matrix is available at the transmitter. We build on recent work that stated the optimization problem without solving for the transformation. Specifically, we provide a closed-form solution for the multi-input single-output (MISO) systems, and a numerical solution for the multi-input multi-output (MIMO) systems. Our results confirm that eigen-beamforming is optimal at low SNR or highly correlated channels, and full diversity is optimal at high SNR or weakly correlated channels.
Problems and feasibility consideration of service-forcused monitoring OSS over mobile networks (2012)

The usage of the mobile phone becomes more diversified, as smart phone users increase and data transmission speed becomes faster by LTE. It is difficult to monitor the network service and maintain stable service quality with the NE-focused monitoring OSS (Operation Support System). In this paper, we show the concept and required functions of the service quality monitoring for mobile networks. Additionally, we propose the implementation of the service quality monitoring OSS to achieve the efficient O&M.
Correlation between apoptotic figure counting and the TUNEL technique. (2000)

AP figure counting seems to be the method of choice for routine work, particularly because of its cost effectiveness and reproducibility.
Selectively Protected Disaccharide Building Blocks for Modular Synthesis of Heparin Fragments (2002)

A modular approach for the synthesis of heparin fragments is described. Levulinoyl esters were employed to protect those hydroxy groups intended to be sulfated in the final product, while acetyl esters and benzyl ethers were used as the permanent protecting groups. A highly efficient chemoenzymatic reaction sequence was used for the deprotection of an O-sulfated fragment, while the final stage of the synthesis entailed a selective oxidation of a primary alcohol of a glucoside with TEMPO/NaOCl to give a glucuronic acid moiety. (© Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002)
Gangliosides shed by tumor cells enhance tumor formation in mice. (1987)

The role of tumor cell membrane gangliosides in tumor formation was probed using a series of cloned murine AKR lymphoma cell lines. Tumor formation was directly related to high expression and shedding of membrane gangliosides. In vivo, as little as 1 pmol of purified total gangliosides of highly tumorigenic cells, injected intradermally with poorly tumorigenic cells (which lacked and did not shed gangliosides), markedly increased the tumorigenicity of these cells in syngeneic normal mice. Thus, gangliosides shed by tumor cells are a previously unrecognized, extremely potent enhancer of tumor formation in vivo.
Binaural sound segregation for multisource reverberant environments (2004)

We present a novel method for binaural sound segregation from acoustic mixtures contaminated by both multiple interference and reverberation. We employ the notion of an ideal time-frequency binary mask, which selects the target if it is stronger than the interference in a local time-frequency (T-F) unit. As opposed to classical adaptive filtering, which focuses on the suppression of noise, our model employs an adaptive filter that performs target cancellation. T-F units dominated by a target are largely suppressed at the output of the cancellation unit when compared to units dominated by noise. Consequently, the actual input-to-output attenuation level in each T-F unit is used to estimate an ideal binary mask. A systematic evaluation in terms of automatic speech recognition performance shows that the resulting system produces masks close to ideal binary ones.
Spirodioxolanonarenones. II.<sup>1</sup> Synthesis of a Halogenated 1,4-Dioxaspiro[4,5]deca-7,9-diene-2,6-dione (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSpirodioxolanonarenones. II.1 Synthesis of a Halogenated 1,4-Dioxaspiro[4,5]deca-7,9-diene-2,6-dioneGian Gualberto Gallo, Carmine Renato Pasqualucci, and Alberto DienaCite this: J. Org. Chem. 1965, 30, 5, 1657–1658Publication Date (Print):May 1, 1965Publication History Published online1 May 2002Published inissue 1 May 1965https://pubs.acs.org/doi/10.1021/jo01016a510https://doi.org/10.1021/jo01016a510research-articleACS PublicationsRequest reuse permissionsArticle Views57Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Effects of Placebo versus Guanabenz on Hypertensive Out-Patients (1980)

The objectives of this study were two-fold: (1) 1 4-week multicentre, randomized, double-blind efficacy comparison of placebo and guanabenz acetate, a new centrally acting antihypertensive drug, in 168 hypertensive out-patients and (2) a more accurate determination of the incidence of drug-related, non-specific side-effects. Both treatment groups were comparable: 68% female, 63% black, mean age 53 years; 57% mild, 32% moderate, 11% moderately severe hypertensives. Seventy-six placebo patients completed 4 weeks and had a mean supine diastolic blood pressure (SDBP) decrease from 105 to 101 mm Hg (p < 0.01). Seventy-nine guanabenz patients completing 4 weeks had a mean SDBP decrease from 104 to 92 mm Hg (p < 0.01). All of the placebo responses and 10/12 mm Hg of the guanabenz response occurred during Week 1. Clinically significant individual SDBP decreases occurred in thirty-one (41%) placebo and fifty-five (70%) guanabenz-treated patients (p < 0.01). Mean daily guanabenz dose was 24 mg. Drug-related biochemical or electrocardiographic abnormalities were absent. Side-effects of sedation and dry mouth were recorded two and three times more frequently, respectively, in guanabenz as compared to placebo patients. Side-effects usually occurred within Week 1 and diminished in incidence thereafter. Consequently, in these patients it appeared that: (1) guanabenz was an effective, well-tolerated drug, (2) placebo effects on efficacy were significant, occurred early and remained stable, and (3) placebo and guanabenz side-effects were mainly sedation and dry mouth.
Integrating anti-EGFR therapies in metastatic colorectal cancer. (2013)

Colorectal cancer remains one of the most common causes of cancer diagnoses and mortality in the United States. The treatment of metastatic colorectal cancer has evolved significantly over the last decade with near-tripling of patient survival rate. A significant contribution to this outcome was the advent of novel targeted agents, such as the epidermal growth factor (EGFR) inhibitors. In an era of emphasis on refining therapy, the presence of KRAS mutation will predict for resistance and limit exposure to patients who are more likely to benefit. In contrast, the presence of BRAF mutations does not seem to have a predictive value. Agents that are thought to reverse resistance to EGFR inhibitors such as those targeting PI3K, c-MET or IGF-1R are currently under study. EGFR inhibitors have exhibited single agent activity, and seem to synergize very well with standard chemotherapy except for cetuximab and 5-fluorouracil, leucovorin, oxaliplatin (FOLFOX). Preliminary data suggests that EGFR inhibitors have similar effectiveness to vascular endothelial growth factor (VEGF) inhibitors in the first line setting. Skin toxicity remains the main limiting factor for the utilization of EGFR inhibitors, but strategies including the use of agents such as minocycline or doxycycline added to topical care seem to limit the severity of the rash.
A Nonclassical Dihydrogen Adduct of <i>S</i> = <sup>1</sup>/<sub>2</sub> Fe(I) (2011)

We have exploited the capacity of the "(SiP(iPr)(3))Fe(I)" scaffold to accommodate additional axial ligands and characterized the mononuclear S = ½ H(2) adduct complex (SiP(iPr)(3))Fe(I)(H(2)). EPR and ENDOR data, in the context of X-ray structural results, revealed that this complex provides a highly unusual example of an open-shell metal complex that binds dihydrogen as a ligand. The H(2) ligand at 2 K dynamically reorients within the ligand-binding pocket, tunneling among the energy minima created by strong interactions with the three Fe-P bonds.
Regional cerebral glucose metabolism in dementia with Lewy bodies and Alzheimer's disease (1998)

These different regional CMRglc reductions substantiate the pathologic, neurochemical, and clinical differences between DLB and AD.
Automated Determination of Serum Glutamic Oxaloacetic Transaminase (1967)

Abstract A new and sensitive procedure is described for the automated determination of serum glutamic oxaloacetic transaminase using the Robot Chemist. Enzymically generated oxaloacetic acid is directly coupled with the diazonium salt, fast ponceau L, to form a colored solution whose absorbance is measured at 455 mµ. Correlations are presented between this method and the AutoAnalyzer procedure using the same reagent.
Intracytoplasmic phosphorylation sites of Tac antigen (p55) are not essential for the conformation, function, and regulation of the human interleukin 2 receptor. (1986)

Tac antigen, the receptor for human interleukin 2 (IL-2), contains in its intracytoplasmic region a serine residue (Ser-247) that is seemingly the predominant site of protein kinase C-mediated phosphorylation. A number of studies on growth factor receptors have suggested the importance of phosphorylation in receptor structure, function, and regulation. In this study, we generated site-directed mutations in the Tac antigen cDNA to generate mutant receptors in which Ser-247 or Thr-250, a probable site of minor phosphorylation, was replaced with another amino acid that is not accessible to phosphorylation. Study of the expression of these mutant genes in a T-lymphoid cell line has provided no evidence as to the essential role of the above-mentioned residues in determining the degree of receptor affinity, its ability for signal transduction, and phorbol ester-mediated regulation of the receptor. Our results strongly suggest the existence of an IL-2 receptor "complex" in which the Tac antigen is associated with another molecule(s) that is involved in receptor structure, function, and regulation.
Synthesis of <sup>13</sup>C and <sup>15</sup>N labeled 2,4‐dinitroanisole (2014)

Syntheses of [(13)C6]-2,4-dinitroanisole (ring-(13)C6) from [(13)C6]-anisole (ring-(13)C6) and [(15)N2]-2,4-dinitroanisole from anisole using in situ generated acetyl nitrate and [(15)N]-acetyl nitrate, respectively, are described. Treatment of [(13)C6]-anisole (ring-(13)C6) with acetyl nitrate generated in 100% HNO3 gave [(13)C6]-2,4-dinitroanisole (ring-(13)C6) in 83% yield. Treatment of anisole with [(15)N]-acetyl nitrate generated in 10 N [(15)N]-HNO3 gave [(15)N2 ]-2,4-dinitroanisole in 44% yield after two cycles of nitration. Byproducts in the latter reaction included [(15)N]-2-nitroanisole and [(15)N]-4-nitroanisole.
Distribution of VP4 gene alleles in human rotaviruses by using probes to the hyperdivergent region of the VP4 gene (1993)

The rotavirus VP4 protein elicits the production of neutralizing antibodies and is known to play a role in inducing resistance to disease. At least five human rotavirus VP4 gene alleles have been described on the basis of antigenic polymorphism and/or nucleotide sequence differences. In the present study, we developed cDNA probes directed at the hyperdivergent region of the VP4 gene of the five described human rotavirus VP4 alleles (Wa, DS1, M37, AU228, and 69M) and used them in hybridization assays with human rotavirus strains from Latin America and Europe to determine the distribution of the VP4 gene alleles in nature. The Wa-like allele was detected most frequently, occurring in 57% of the 402 rotavirus strains tested, and the DS1-like allele was the next most common, occurring in 14% of the strains tested. The M37- and AU228-like alleles were detected in only 4 and 3% of the rotavirus strains tested, respectively, whereas the 69M-like VP4 gene allele was not detected. Several rotavirus strains from Europe did not react with any of the VP4 gene probes, although they did hybridize to a probe generated from a representative strain from the group. These data indicate the global distribution of various VP4 gene alleles and raise the possibility that other, unrecognized human VP4 alleles exist in nature because almost one-fourth of the strains could not be classified into any of the established VP4 groups.
Corrosion of Boiler Steels by Inhibited Hydrochloric Acid (1948)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCorrosion of Boiler Steels by Inhibited Hydrochloric AcidP. H. Cardwell and S. J. MartinezCite this: Ind. Eng. Chem. 1948, 40, 10, 1956–1964Publication Date (Print):October 1, 1948Publication History Published online1 May 2002Published inissue 1 October 1948https://pubs.acs.org/doi/10.1021/ie50466a025https://doi.org/10.1021/ie50466a025research-articleACS PublicationsRequest reuse permissionsArticle Views81Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Toward the automated editing of theme oriented video sequences (1997)

This article considers the automated generation of humorous video sequences from arbitrary video material. We present a simplified model of the editing process. We then outline our approach to narrativity and visual humor, discuss the problems of context and shot order in video, and consider influences on the editing process. We describe the role of themes and semantic fields in the generation of content-oriented video scenes. We then present the architecture of AUTEUR, an experimental system that embodies mechanisms to interpret, manipulate, and generate video. An example of a humorous video sequence generated by AUTEUR is described.
Prostatic tumor regrowth after initially successful castration therapy may be related to a decreased apoptotic cell death rate. (1994)

Castration of rats transplanted with the androgen-sensitive Dunning R3327-PAP prostatic tumor results initially in a reduction of tumor growth, but after some time, some of the tumors start to grow again. The relapsed, androgen-insensitive PAP tumor shows a dedifferentiated morphology. In the present study, we examined whether this androgen-independent tumor regrowth was due to an increased cell proliferation rate or to a reduction of the number of tumor cells dying by apoptosis. Nine rats (with 18 tumors) were castrated and followed for 16 to 20 weeks. Six of the tumors increased their volume markedly (relapsed), while 12 remained relatively stable (nonrelapsed). The mitotic index and apoptotic index for epithelial cells were examined by light microscopy. Tumor growth rate correlated negatively both to the apoptotic index identified by morphological criteria (RS = -0.82; P < 0.0001) and to the apoptotic index identified by in situ end labeling (RS = -0.83; P < 0.0001). The tumor growth rate percentage did not correlate to the mitotic index, and it was negatively correlated (RS = -0.62; P < 0.01) to the number of cells immunostained for proliferating cell nuclear antigen. It is suggested that one initial event during the androgen-independent prostatic tumor regrowth in the PAP relapse model might be a reduction of the number of tumor cells being depleted by apoptosis, rather than an increase of cell proliferation rate.
Modeling and Simulation of Call Centers (2006)

In this review, we introduce key notions and describe the decision problems commonly encountered in call center management. Main themes are the central role of uncertainty throughout the decision hierarchy and the many operational complexities and relationships between decisions. We make connections to analytical models in the literature, emphasizing insights gained and model limitations. The high operational complexity and the prevalent uncertainty suggest that simulation modeling and simulation-based decision making could have a central role in the management of call centers. We formulate some common decision problems and point to recently developed simulation-based solution techniques. We review recent work that supports modeling the primitive inputs to a call center and highlight call center modeling difficulties.