gebhart/patrepeval huggingface dataset:
Kinematics and dynamic complexity of postural transitions in frail elderly subjects (2007)

The aim of this study was to propose a methodology allowing a detailed characterization of body sit-to-stand/stand-to-sit postural transition. Parameters characterizing the kinematics of the trunk movement during sit-to-stand (Si-St) postural transition were calculated using one initial sensor system fixed on the trunk and a data logger. Dynamic complexity of these postural transitions was estimated by fractal dimension of acceleration-angular velocity plot. We concluded that this method provides a simple and accurate tool for monitoring frail elderly and to objectively evaluate the efficacy of a rehabilitation program.
FORMATION OF SEROLOGICALLY REACTIVE DEXTRANS BY STREPTOCOCCI FROM SUBACUTE BACTERIAL ENDOCARDITIS (1946)

Serologically reactive dextrans were synthesized from sucrose by 22 of 48 strains of streptococci isolated from the blood of patients with subacute bacterial endocarditis. One strain formed an appreciable amount of levan as well as dextran. Nine strains of group H streptococci from throats formed dextran serologically similar to that formed by the described endocarditis streptococci. Six strains of S. salivarius from throats and feces, which were included for comparison, formed levan which agreed in serological properties with the purified levan previously described for one strain of that species. The experimental method comprised a series of serological tests that were controlled and supplemented by physical and chemical tests, and furnished a relatively simple but entirely adequate way of recognizing and distinguishing dextrans and levans in bacterial cultures without isolation of the purified polysaccharides. The possible use of dextran and levan formation in the differential description of non-hemolytic streptococci is suggested.
ChemInform Abstract: MODIFICATION OF (S)‐N,N‐DIMETHYL‐1‐((R)‐1′,2‐BIS(DIPHENYLPHOSPHINO)FERROCENYL)ETHYLAMINE (BPPFA) AS A LIGAND FOR ASYMMETRIC HYDROGENATION OF OLEFINS CATALYZED BY A CHIRAL RHODIUM(I) COMPLEX (1980)

Abstract Die Modifizierung der Titelverbindung wurde durch Austausch einer an das asymm. C‐Atom gebundenen Methylgruppe gegen 12A eine Phenyl‐ bzw. Isopropylgruppe erreicht, um den sterischen Einfluß des asymm. Zentrums auf die Konformation des Chelats und die Wirksamkeit der chiralen Liganden bei ihrer katalytischen Verwendung in Form von Rh(I)‐Komplexen zu untersuchen.
Dynamic and scalable large scale image reconstruction (2010)

Recent approaches to reconstructing city-sized areas from large image collections usually process them all at once and only produce disconnected descriptions of image subsets, which typically correspond to major landmarks. In contrast, we propose a framework that lets us take advantage of the available meta-data to build a single, consistent description from these potentially disconnected descriptions. Furthermore, this description can be incrementally updated and enriched as new images become available. We demonstrate the power of our approach by building large-scale reconstructions using images of Lausanne and Prague.
Conjugated Polymer Nanoparticles for Drug Delivery and Imaging (2010)

We prepared a new conjugated polymer nanoparticle with the size of about 50 nm that is prepared by electrostatic assembly of cationic conjugated polymer PFO and anionic poly(l-glutamic acid) conjugated with anticancer drug doxorubicin (PFO/PG-Dox). The PFO exhibits good fluorescence quantum yield, photostability, and little cytotoxicity to meet the essential requests for cell imaging. In PFO/PG-Dox nanoparticles, the fluorescence of PFO is highly quenched by Dox by electron transfer mechanism, and thus the PFO is in the fluorescence "turn-off' state. After PFO/PG-Dox nanoparticles are exposed to carboxypeptidase or are taken up by cancer cells, the poly(l-glutamic acid) is hydrolysed to release the Dox, inducing the activation of PFO fluorescence to "turn-on" state. This multifunctional nanoparticle system can deliver Dox to targeted cancer cells and monitor the Dox release based on fluorescence "turn-on" signal of PFO, which concurrently images the cancer cells. The present work opens the door for new functional studies of conjugated polymer in simultaneous imaging and disease therapeutics.
A rapid modified gas chromatographic method for carbohydrate analysis of wood pulps (1997)

The current procedure of TAPPI Test Method T 249 cm-85 for carbohydrate analysis requires acetylation of alditols. Preparation of alditol acetates involves a series of evaporation steps. This investigation is an attempt to improve the efficiency of this gas chromatography method. Using 1-methylimidazole as a catalyst, acetylation of alditols in the presence of borates has been successfully accomplished. This eliminates the need for the evaporation steps. Analysis of a number of different pulp samples, using the modified method, showed accurate and repeatable results. The monosaccharide compositions were comparable with the conventional TAPPI method. Application : a modified method for carbohydrate analysis makes it possible to characterize wood pulp carbohydrates faster than with TAPPI Test Method T249 cm-85, without losing accuracy.
Pyroelectric response in crystalline hafnium zirconium oxide (Hf1-<i>x</i>Zr<i>x</i>O2) thin films (2017)

Pyroelectric coefficients were measured for 20 nm thick crystalline hafnium zirconium oxide (Hf1-xZrxO2) thin films across a composition range of 0 ≤ x ≤ 1. Pyroelectric currents were collected near room temperature under zero applied bias and a sinusoidal oscillating temperature profile to separate the influence of non-pyroelectric currents. The pyroelectric coefficient was observed to correlate with zirconium content, increased orthorhombic/tetragonal phase content, and maximum polarization response. The largest measured absolute value was 48 μCm−2 K−1 for a composition with x = 0.64, while no pyroelectric response was measured for compositions which displayed no remanent polarization (x = 0, 0.91, and 1).
<title>Spectrophotometry and beam profile reflectometry measurement of six layers in an SOI film stack</title> (1996)

We developed a robust measurement recipe for six layer SOI film stack. Both spectrometer and BPR were combined to characterize the plate and storage polysilicons. A new global optimization method was developed to find the best solution in parameter spaces with up to 12 parameters. Such a recipe was applied to production wafers with over 50 site die mapping. The 5 day repeatability shows the measurements were stable and robust.
NFkappaB decoy oligodeoxynucleotides reduce monocyte infiltration in renal allografts. (2000)

International audience
Copolymer of poly(ethylene glycol) and poly(<scp>l</scp>-lysine) grafting polyethylenimine through a reducible disulfide linkage for siRNA delivery (2013)

siRNA therapy research has primarily focused on the synthesis and development of effective siRNA delivery vectors with easy biodegradability and low toxicity. In the present study, we synthesized a ternary copolymer mPEG-b-PLL-g-(ss-lPEI), denoted as PLI, by introducing disulfide bond linkages to graft low molecular weight linear polyethylenimine (lPEI) to the block copolymer of poly(L-lysine) (PLL) and poly(ethylene glycol) (PEG) for siRNA delivery. The PLL block and disulfide linkage rendered the carrier biodegradability, while lPEI grafting brought about the proton buffering capacity for lysosomal siRNA release and low cationic toxicity. Conjugation of a single chain monoclonal antibody (Herceptin) to the carrier as a targeting ligand for the Her2/neu receptor significantly increased the transfection activity of the copolymer/siRNA nanocomplex (i.e. the polyplex) in Skov-3, a human ovarian cancer cell line. Determination of gene expression at both the mRNA and protein levels demonstrated that Her2-targeted delivery of siRNA (XIAP siRNA) effectively downregulated the targeted XIAP (X-linked inhibitor of apoptosis protein) gene, resulting in enhanced cancer cell apoptosis and improved therapeutic efficacy in vitro and in vivo. The distinct features of low cytotoxicity, easy degradability, and high siRNA transfection efficiency make the copolymer a promising candidate for siRNA therapy in tumors.
A novel sensitized photochromic organic glass for holographic optical storage (1996)

A new class of photochromic glasses for use in irreversible holographic optical storage applications is described. The recording mechanism involves a triplet-sensitized photoreaction of an organic chromophore. The materials are isotropic and red-sensitive, and exhibit high diffraction efficiencies and long hologram lifetimes. The wavelength sensitivity can be adjusted by the choice of sensitizer; C60, sensitive in the red, is described here. Single digital data page recording and error-free readout are demonstrated at a density of 0.5 Mb/cm2; multiplexing in a 150-μm-thick sample is also demonstrated.
Ubiquitin-dependent Proteolytic Control of SUMO Conjugates (2007)

Posttranslational protein modification with small ubiquitin-related modifier (SUMO) is an important regulatory mechanism implicated in many cellular processes, including several of biomedical relevance. We report that inhibition of the proteasome leads to accumulation of proteins that are simultaneously conjugated to both SUMO and ubiquitin in yeast and in human cells. A similar accumulation of such conjugates was detected in Saccharomyces cerevisiae ubc4 ubc5 cells as well as in mutants lacking two RING finger proteins, Ris1 and Hex3/Slx5-Slx8, that bind to SUMO as well as to the ubiquitin-conjugating enzyme Ubc4. In vitro, Hex3-Slx8 complexes promote Ubc4-dependent ubiquitylation. Together these data identify a previously unrecognized pathway that mediates the proteolytic down-regulation of sumoylated proteins. Formation of substrate-linked SUMO chains promotes targeting of SUMO-modified substrates for ubiquitin-mediated proteolysis. Genetic and biochemical evidence indicates that SUMO conjugation can ultimately lead to inactivation of sumoylated substrates by polysumoylation and/or ubiquitin-dependent degradation. Simultaneous inhibition of both mechanisms leads to severe phenotypic defects.
Preparation of Immunoglobulin Y from Egg Yolk Using Ammonium Sulfate Precipitation and Ion Exchange Chromatography (2007)

The objective of this study was to develop an economical, simple, and large-scale separation method for IgY from egg yolk. Egg yolk diluted with 9 volumes of cold water was centrifuged after adjusting the pH to 5.0. The supernatant was added with 0.01% charcoal or 0.01% carrageenan and centrifuged at 2,800 x g for 30 min. The supernatant was filtered through a Whatman no. 1 filter paper and then the filtrate was concentrated to 20% original volume using ultrafiltration. The concentrated solution was further purified using either cation exchange chromatography or ammonium sulfate precipitation. For the cation exchange chromatography method, the concentrated sample was loaded onto a column equilibrated with 20 mM citrate-phosphate buffer at pH 4.8 and eluted with 200 mM citrate-phosphate buffer at pH 6.4. For the ammonium sulfate precipitation method, the concentrated sample was twice precipitated with 40% ammonium sulfate solution at pH 9.0. The yield and purity of IgY were determined by ELISA and electrophoresis. The yield of IgY from the cation exchange chromatography method was 30 to 40%, whereas that of the ammonium sulfate precipitation was 70 to 80%. The purity of IgY from the ammonium sulfate method was higher than that of the cation exchange chromatography. The cation exchange chromatography could handle only a small amount of samples, whereas the ammonium sulfate precipitation could handle a large volume of samples. This suggests that ammonium sulfate precipitation was a more efficient and useful purification method than cation exchange chromatography for the large-scale preparation of IgY from egg yolk.
An efficient TDMA start-up and restart synchronization approach for distributed embedded systems (2004)

A desired attribute in safety-critical embedded real-time systems is a system time and event synchronization capability on which predictable communication can be established. Focusing on bus-based communication protocols, we present a novel, efficient, and low-cost start-up and restart synchronization approach for TDMA environments. This approach utilizes information about a node's message length that forms a unique sequence to achieve synchronization such that communication overhead can be avoided. We present a fault-tolerant initial synchronization protocol with a bounded start-up time. The protocol avoids start-up collisions by deterministically postponing retries after a collision. We also present a resynchronization strategy that incorporates recovering nodes into synchronization.
Genetic analysis of Drosophila neurons: Shal, Shaw, and Shab encode most embryonic potassium currents (1995)

In this study, we perform the first genetic analysis of K+ currents in Drosophila embryonic neurons revealing the identity of the currents present. Unlike muscles, where the presence of Shaker is obvious, Shaker currents are not detectable in these neurons. In contrast, we show that Shal is as important in these neuronal cell bodies as Shaker is in muscles. Only three single-channel currents were found, all of which are genetically separable. Shal encodes a 4 pS transient channel. Whole-cell Shal currents have a wide variety of inactivation rates which, in contrast to a mechanism such as heteromultimer formation, is due to single Shal channels assuming different gating modes. Shaw encodes a 42 pS noninactivating channel distinctive for its extremely low voltage sensitivity; Shaw channels have a total equivalent gating charge of 0.90 e- charges, in sharp contrast to 7 e- reported for Shaker channels. An 11 pS slowly inactivating channel also present in these neurons may be encoded by the Shab gene. Thus, of four voltage-dependent K+ channel genes now cloned in Drosophila, all except Shaker appear to be expressed in the cell bodies of these neurons. It is only in Drosophila that a study such as this one can be done. Because Drosophila contains only a single member of each of the four subfamilies of K+ channel genes (unlike mammals), we can eliminate an entire subfamily with a mutation to a single gene. Here, we have examined the effect of eliminating each of three subfamilies. Such a task is presently impossible to accomplish in any mammalian system.
High‐Yield Fabrication and Electrochemical Characterization of Tetrapodal CdSe, CdTe, and CdSe<sub><i>x</i></sub>Te<sub>1–</sub><sub><i>x</i></sub> Nanocrystals (2006)

Abstract The high‐yield fabrication of tetrapodal CdSe, CdTe, and CdSe x Te 1– x nanocrystals is systematically studied. CdSe nanocrystals are prepared by first controlling the synthesis of high‐quality wurtzite CdSe and zinc blende CdSe nanocrystals at a relatively high temperature (260 °C) by selecting different ligands. Then, based on the phase control of the CdSe nanocrystals, two nanoparticle‐tailoring routes (i.e., a seed‐epitaxial route and ligand‐dependent multi‐injecting route) are used, and a high yield of CdSe tetrapods is obtained. CdTe nanocrystals are prepared by adjusting the ligand composition and the ratio of Cd to Te; CdTe tetrapods are synthesized in high yield using a mixed ligand that does not contain alkylphosphonic acids. Moreover, the nanoscale Te powder (Te nanowires/nanorods), which is highly soluble in the ligand solvent, is first used as a Te source to synthesize CdTe nanocrystals, which remarkably enhanced the output of the CdTe nanocrystals in one reaction. Furthermore, composition‐tunable ternary CdSe x Te 1– x alloyed tetrapods are synthesized on a large scale, for the first time, by thermolyzing the mixture of the organometallic Cd precursor and the mixed (Se + Te) source in a mixed‐ligand solution. The CdSe, CdTe, and CdSe x Te 1– x nanocrystals are characterized by transmission electron microscopy (TEM), high‐resolution TEM, selected‐area electron diffraction, X‐ray diffraction, and UV‐vis and photoluminescence (PL) spectroscopy. Interesting nonlinear, composition‐dependent absorption and PL spectra are observed for the ternary CdSe x Te 1– x alloyed nanocrystals. The band‐edge positions of the nanocrystals of CdSe, CdSe x Te 1– x , and CdTe are systematically studied by cyclic voltammetry.
Short‐ and long‐duration responses to levodopa during the first year of levodopa therapy (1997)

We examined the response to 2-hour levodopa infusions in 18 Parkinson's disease subjects before starting long-term levodopa treatment and after 6 and 12 months of treatment using tapping speed as an index of bradykinesia. The long-duration response (LDR), measured as the increase in baseline (overnight without levodopa) tapping speed, increased by 29 +/- 18 at 6 months and by 35 +/- 24 at 12 months. The magnitude of the short-duration response (SDR) to a 2-hour levodopa infusion after an overnight levodopa withdrawal did not differ at 6 and 12 months (16 +/- 8 and 20 +/- 13 taps/min) from that before long-term levodopa (21 +/- taps/min). However, when levodopa was withheld for 3 days, it was evident that the SDR magnitude was increasing in magnitude (19, 23, and 31 taps/min at 0, 6, and 12 months). Duration of SDR did not change. A diurnal motor pattern with faster tapping speeds in the morning and slower in the evening was apparent on the days no levodopa was administered. These observations indicate (1) the LDR is responsible for much of the sustained response to levodopa during the first year of treatment, (2) the SDR magnitude increases but is obscured by the LDR, and (3) a diurnal pattern of motor function is present that may be partially responsible for the poorer motor function in the afternoons and evenings.
Model Silicone Elastomer Networks of High Juction Functionality: Synthesis, Tensile Behavior, Swelling Behavior, and Comparison with Molecular Theories of Rubber Elasticity (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTModel Silicone Elastomer Networks of High Juction Functionality: Synthesis, Tensile Behavior, Swelling Behavior, and Comparison with Molecular Theories of Rubber ElasticityK. O. Meyers, M. L. Bye, and E. W. MerrillCite this: Macromolecules 1980, 13, 5, 1045–1053Publication Date (Print):September 1, 1980Publication History Published online1 May 2002Published inissue 1 September 1980https://pubs.acs.org/doi/10.1021/ma60077a005https://doi.org/10.1021/ma60077a005research-articleACS PublicationsRequest reuse permissionsArticle Views427Altmetric-Citations58LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Biosynthesis of astaxanthin in tobacco leaves by transplastomic engineering (2008)

The natural pigment astaxanthin has attracted much attention because of its beneficial effects on human health, despite its expensive market price. In order to produce astaxanthin, transgenic plants have so far been generated through conventional genetic engineering of Agrobacterium-mediated gene transfer. The results of trials have revealed that the method is far from practicable because of low yields, i.e. instead of astaxanthin, large quantities of the astaxanthin intermediates, including ketocarotenoids, accumulated in the transgenic plants. In the present study, we have overcome this problem, and have succeeded in producing more than 0.5% (dry weight) astaxanthin (more than 70% of total caroteniods) in tobacco leaves, which turns their green color to reddish brown, by expressing both genes encoding CrtW (beta-carotene ketolase) and CrtZ (beta-carotene hydroxylase) from a marine bacterium Brevundimonas sp., strain SD212, in the chloroplasts. Moreover, the total carotenoid content in the transplastomic tobacco plants was 2.1-fold higher than that of wild-type tobacco. The tobacco transformants also synthesized a novel carotenoid 4-ketoantheraxanthin. There was no significant difference in the size of the aerial part of the plant between the transformants and wild-type plants at the final stage of their growth. The photosynthesis rate of the transformants was also found to be similar to that of wild-type plants under ambient CO2 concentrations of 1500 micromol photons m(-2) s(-1) light intensity.
Radar (1946)

Since a fairly large percentage of the effort of physicists and electrical engineers in this country and in England was expended on radar development during the war, techniques in electronics have advanced at possibly ten times the normal peacetime rate. The purpose of this paper is to give a brief survey of the wartime developments in electronics and to show how these were used in a few radar sets. Because the applications of radar to civilian activities will probably be of minor importance when compared with the sum total of other electronic applications, this survey makes no attempt to give a complete description of any particular radar set. Those readers who are interested in a detailed description of a radar installation will find complete inforrration on the SCR-268 in the literature.
Hierarchical diagnosis strategy fora n auto motive electrical power generation system (2008)

This paper presents a hierarchical signal knowledge-based approach to fault detection and isolation (FDI) for an automotive electrical power generation system. The system we deal with is characterized by two main components: an alternator and a belt and it is subjected to constraints on the available measures (the alternator current is not available) and the computational power. The proposed approach is able to detect and isolate different faults combining, into a rule based logic, information carried by the measured signals. The hierarchical feature of the proposed diagnostic logic makes the implementation computationally efficient allowing the diagnosis algorithm to run in real time.
Promoter structure and transcription initiation sites of the human death receptor 5/TRAIL‐R2 gene<sup>1</sup> (2001)

The death receptor 5 (DR5) is a receptor for tumor necrosis factor-related apoptosis-inducing ligand and is able to induce apoptosis in various tumor cells. The expression of DR5 is up-regulated at the transcriptional level by p53, genotoxic stress and so on. To investigate the structure of the DR5 gene promoter, we screened and sequenced a genomic clone containing the 5'-flanking region of the DR5 gene. RNase protection assays showed two major transcription start sites around -122 and -137 upstream of the translation initiation codon ATG. Transient transfections with serial 5'-deletion mutants identified the minimal promoter element spanning -198 to -116. Site-directed mutagenesis demonstrated that the DR5 gene promoter has no typical TATA-box, but has two Sp1 sites responsible for the basal transcription activity of the DR5 gene promoter.