gebhart/patrepeval huggingface dataset:
Studies on pyrazines.<b>7</b>. The synthesis of 5‐chloropyrazinecarboxylic acid (1982)

Abstract The titled carboxylic acid ( 1 ) was prepared by condensation of 2‐furylglyoxal with aminoacetamide followed by chlorination of the resulting 2‐hydroxy‐5‐(2′‐furyl)pyrazine ( 2 ) and permanganate oxidation. The acid was further converted into methyl ester and 5‐hydroxypyrazinecarboxylic acid.
Generation of Magnetic Flux by Single Grain Boundaries of<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mrow><mml:msub><mml:mrow><mml:mi>YBa</mml:mi></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msub></mml:mrow><mml:mrow><mml:msub><mml:mrow><mml:mi>Cu</mml:mi></mml:mrow><mml:mrow><mml:mn>3</mml:mn></mml:mrow></mml:msub></mml:mrow><mml:mrow><mml:msub><mml:mrow><mml:mi>O</mml:mi></mml:mrow><mml:mrow><mml:mn>7</mml:mn><mml:mo>−</mml:mo></mml:mrow></mml:msub></mml:mrow></mml:mrow><mml:mrow><mml:mi mathvariant="italic">x</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math> (1996)

Using scanning SQUID microscopy, we have directly imaged spontaneously generated delocalized magnetic flux in 45\ifmmode^\circ\else\textdegree\fi{} [001] tilt grain boundaries in ${\mathrm{YBa}}_{2}{\mathrm{Cu}}_{3}{\mathrm{O}}_{7\ensuremath{-}x}$ films. Implications for the transport properties of the grain boundaries are discussed. A model based on a ${d}_{{x}^{2}{\ensuremath{-}y}^{2}}$-wave symmetry component of the superconducting order parameter and on grain-boundary faceting is consistent with the results of our experiments.
Learning Spherical Convolution for Fast Features from 360° Imagery (2017)

While 360° cameras offer tremendous new possibilities in vision, graphics, and augmented reality, the spherical images they produce make core feature extraction non-trivial. Convolutional neural networks (CNNs) trained on images from perspective cameras yield “flat filters, yet 360° images cannot be projected to a single plane without significant distortion. A naive solution that repeatedly projects the viewing sphere to all tangent planes is accurate, but much too computationally intensive for real problems. We propose to learn a spherical convolutional network that translates a planar CNN to process 360° imagery directly in its equirectangular projection. Our approach learns to reproduce the flat filter outputs on 360° data, sensitive to the varying distortion effects across the viewing sphere. The key benefits are 1) efficient feature extraction for 360° images and video, and 2) the ability to leverage powerful pre-trained networks researchers have carefully honed (together with massive labeled image training sets) for perspective images. We validate our approach compared to several alternative methods in terms of both raw CNN output accuracy as well as applying a state-of-the-art “flat object detector to 360° data. Our method yields the most accurate results while saving orders of magnitude in computation versus the existing exact reprojection solution.
Prediction of energy decay in room impulse responses simulated with an image-source model (2008)

A method is proposed that provides an approximation of the acoustic energy decay (energy-time curve) in room impulse responses generated using the image-source technique. A geometrical analysis of the image-source principle leads to a closed-form expression describing the energy decay curve, with the resulting formula being valid for a uniform as well as nonuniform definition of the enclosure's six absorption coefficients. The accuracy of the proposed approximation is demonstrated on the basis of impulse-response simulations involving various room sizes and reverberation levels, with uniform and nonuniform sound absorption coefficients. An application example for the proposed method is illustrated by considering the task of predicting an enclosure's reflection coefficients in order to achieve a specific reverberation level. The technique presented in this work enables designers to undertake a preliminary analysis of a simulated reverberant environment without the need for time-consuming image-method simulations.
Hsp70 overexpression inhibits NF‐κB and Foxo3a transcriptional activities and prevents skeletal muscle atrophy (2008)

Heat shock protein 70 (Hsp70) is a highly conserved and ubiquitous protein that is reported to provide cytoprotection in various cell types and tissues. However, the importance of Hsp70 expression during skeletal muscle atrophy, when Hsp70 levels are significantly decreased, is not known. The current study aimed to determine whether plasmid-mediated overexpression of Hsp70, in the soleus muscle of rats, was sufficient to regulate specific atrophy signaling pathways and attenuate skeletal muscle disuse atrophy. We found that Hsp70 overexpression prevented disuse muscle fiber atrophy and inhibited the increased promoter activities of atrogin-1 and MuRF1. Importantly, the transcriptional activities of Foxo3a and NF-kappaB, which are implicated in the regulation of atrogin-1 and MuRF1, were abolished by Hsp70. These data suggest that Hsp70 may regulate key atrophy genes through inhibiting Foxo3a and NF-kappaB activities during disuse. Indeed, we show that specific inhibition of Foxo3a prevented the increases in both atrogin-1 and MuRF1 promoter activities during disuse. However, inhibition of NF-kappaB did not affect the activation of either promoter, suggesting its requirement for disuse atrophy is through its regulation of other atrophy genes. We conclude that overexpression of Hsp70 is sufficient to inhibit key atrophy signaling pathways and prevent skeletal muscle atrophy.
[Photorefractive keratectomy for myopia: 6 month results]. (1995)

The argon fluoride excimer laser is able to ablate the superficial cornea and to correct refractive problems. Photorefractive keratectomy (PRK) was performed on 103 myopic eyes ranging from -0.75D to -6.00D. We prospectively evaluated visual and refractive results that were followed for more than 6 months. Uncorrected visual acuity of 1.0 or better was achieved in 88.35%. The difference between attempted and achieved refractive correction was within +/- 1.00D in 94.17%. 10 eyes (9.71%) had trace to mild subepithelial hare and 19 eyes (18.45%) had loss of one line of best spectacle corrected visual acuity. The excimer laser PRK appears to be a predictable and effective method to correct myopia under -6.00D.
Review of Wesley J. Smith's A Rat is a Pig is a Dog is a Boy: The Human Cost of the Animal Rights Movement (2010)

Ingrid Newkirk’s notorious assertion that “a rat is a pig is a dog is a boy” provides the title for Wesley J. Smith’s book decrying the animal-liberation movement and propounding the doctrine of human exceptionalism. More than simply a claim about the superior mental powers of Homo sapiens, human exceptionalism holds that humans possess a unique moral worth that endows them alone, among all living creatures, with the right never to be treated merely as means to the ends of others. The idea that humans have this exceptional moral status is hardly new, but the fact that it has now become an “ism” reflects the current struggle over where to draw the boundaries of the moral community.
Optoacoustic real-time dosimetry for selective retina treatment (2005)

The selective retina treatment (SRT) targets retinal diseases associated with disorders in the retinal pigment epithelium (RPE). Due to the ophthalmoscopic invisibility of the laser-induced RPE effects, we investigate a noninvasive optoacoustic real-time dosimetry system. In vitro porcine RPE is irradiated with a Nd:YLF laser (527 nm, 1.7-micros pulse duration, 5 to 40 microJ, 30 pulses, 100-Hz repetition rate). Generated acoustic transients are measured with a piezoelectric transducer. During 27 patient treatments, the acoustic transients are measured with a transducer embedded in an ophthalmic contact lens. After treatment, RPE damage is visualized by fluorescein angiographic leakage. Below the RPE damage threshold, the optoacoustic transients show no pulse-to-pulse fluctuations within a laser pulse train. Above threshold, fluctuations of the individual transients among each other are observed. If optoacoustic pulse-to-pulse fluctuations are present, RPE leakage is observed in fluorescein angiography. In 96% of the irradiated areas, RPE leakage correlated with the optoacoustic defined threshold value. A noninvasive optoacoustic real-time dosimetry for SRT is developed and proved in vitro and during patient treatment. It detects the ophthalmoscopically invisible laser-induced damage of RPE cells and overcomes practical limitations of SRT for use in private practice.
Cryosurgery: Theory and application to head and neck neoplasia (1979)

While surgery and radiation therapy remain the time-tested modalities for the treatment of cancer in the head and neck, recent experimental and clinical experience has documented the effectiveness of cryosurgery as an adjunct in the treatment of selected neoplasms in individual patients. A review is provided of the theory of freezing as a method of cell destruction, and experimental and clinical experience illustrate the principles and application of cryosurgery to head and neck tumors.
Properties of Vapor Deposited Silicon Nitride Films with Varying Excess Si Content (1973)

Physical, chemical and electrical properties of Si rich silicon nitride (SiN) film deposited by using the SiH4–NH3 system have been studied. By changing the volume ratio of NH3 to SiH4 from 100 to 1/30, samples with varying excess Si content within SiN films can be obtained. The current conduction mechanism of the SiN film can be represented by the superposition of Poole-Frenkel current, field ionization current and hopping current as reported by Sze in the Si3N4 films without Si excess. Energy levels of trapping centers responsible for Poole-Frenkel current become shallow while their densities remain nearly constant as a function of the Si content. From the dependence of the shift characteristics of C–V curves, it has been deduced that the maximum charge storage within the SiN film is controlled by current conduction through the film.
Progesterone Withdrawal Reduces Paired-Pulse Inhibition in Rat Hippocampus: Dependence on GABA<sub>A</sub>Receptor α4 Subunit Upregulation (2003)

Withdrawal from the endogenous steroid progesterone (P) after chronic administration increases anxiety and seizure susceptibility via declining levels of its potent GABA-modulatory metabolite 3alpha-OH-5alpha-pregnan-20-one (3alpha,5alphaTHP). This 3alpha,5alpha-THP withdrawal also results in a decreased decay time constant for GABA-gated current assessed using whole cell patch-clamp techniques on pyramidal cells acutely dissociated from CA1 hippocampus. The purpose of this study was to test the hypothesis that the decreases in total integrated GABA-gated current observed at the level of the isolated pyramidal cell would be manifested as a reduced GABA inhibition at the circuit level following hormone withdrawal. Toward this end, adult, female rats were administered P via subcutaneous capsule for 3 wk using a multiple withdrawal paradigm. We then evaluated paired-pulse inhibition (PPI) of pyramidal neurons in CA1 hippocampus using extracellular recording techniques in hippocampal slices from rats 24 h after removal of the capsule (P withdrawal, P Wd). The population spike (PS) was recorded at the stratum pyramidale following homosynaptic orthodromic stimulation in the nearby stratum radiatum. The threshold for eliciting a response was decreased after P Wd, and the mean PS amplitude was significantly increased compared with control values at this time. Paired pulses with 10-ms inter-pulse intervals were then applied across an intensity range from 2 to 20 times threshold. Evaluation of paired-pulse responses showed a significant 40-50% reduction in PPI for PS recorded in the hippocampal CA1 region after P Wd, suggesting an increase in circuit excitability. At this time, enhancement of PPI by the benzodiazepine lorazepam (LZM; 10 microM) was prevented, while pentobarbital (10 microM) potentiation of PPI was comparable to control levels of response. These data are consistent with upregulation of the alpha4 subunit of the GABA(A) receptor (GABAR) as we have previously shown. Moreover, the reduced PPI caused by P Wd was prevented by suppression of GABAR alpha4-subunit expression following intraventricular administration of specific antisense oligonucleotides (1 microg/h for 72 h). These results demonstrating a reduction in PPI following P Wd suggest that GABAergic-mediated recurrent or feed-forward inhibition occurring at the circuit level were decreased following P Wd in female rats, an effect at least partially attributable to alterations in the GABAR subunit gene expression.
State-of-the-Art of Serum Testosterone Measurement by Isotope Dilution–Liquid Chromatography– Tandem Mass Spectrometry (2008)

This study demonstrated fairly good accuracy and standardization of the tested ID-LC-MS/MS procedures. Performance differences between procedures were evident in some instances, due to improper calibration and between-run calibration control. This emphasizes the need for thorough validation, including traceability, of new ID-LC-MS/MS procedures.
Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway (2010)

The Hedgehog (Hh) pathway is activated in some human cancers, including medulloblastoma. The glioma-associated oncogene homolog (GLI) transcription factors are critical mediators of the activated Hh pathway, and their expression may be elevated in some tumors independent of upstream Hh signaling. Thus, therapies targeting GLI transcription factors may benefit a wide spectrum of patients with mutations at different nodal points of the Hh pathway. In this study, we present evidence that arsenic trioxide (ATO) suppresses human cancer cell growth and tumor development in mice by inhibiting GLI1. Mechanistically, ATO directly bound to GLI1 protein, inhibited its transcriptional activity, and decreased expression of endogenous GLI target genes. Consistent with this, ATO inhibited the growth of human cancer cell lines that depended on upregulated GLI expression in vitro and in vivo in a xenograft model of Ewing sarcoma. Furthermore, ATO improved survival of a clinically relevant spontaneous mouse model of medulloblastoma with activated Hh pathway signaling. Our results establish ATO as a Hh pathway inhibitor acting at the level of GLI1 both in vitro and in vivo. These results warrant the clinical investigation of ATO for tumors with activated Hh/GLI signaling, in particular patients who develop resistance to current therapies targeting the Hh pathway upstream of GLI.
Long‐term serotonin administration leads to higher bone mineral density, affects bone architecture, and leads to higher femoral bone stiffness in rats (2005)

New evidence suggests a control of bone mass by the central nervous system. We have previously shown that functional serotonin receptors are present in bone cells and that serotonin stimulates proliferation of osteoblast precursor cells in vitro. In the present study we investigated the effects of serotonin on bone tissue in vivo. Ten, 2-month-old female Sprague-Dawley rats were injected with serotonin subcutaneously (s.c.) (5 mg/kg) once daily for 3 months, controls received saline. Using microdialysis and HPLC, free circulating serotonin levels were measured. DXA scans were made after 3 months of serotonin administration. Bone architecture and mechanical properties were investigated by micro-computed tomography (microCT), histomorphometry, and mechanical testing. A long-lasting hyperserotoninemia with a >10-fold increase in serotonin appeared. Total body BMD was significantly higher (0.1976+/-0.0015 vs. 0.1913+/-0.0012 g/cm2) in rats receiving serotonin. Cortical thickness (Ct.Th) measured by microCT analysis was also higher, whereas trabecular bone volume (BV) was lower. Interestingly, the perimeter and cross-sectional moment of inertia (MOI), a proxy for geometrical bone strength, were the same in both groups. These data suggest that serotonin reduces resorption or/and increases apposition of endosteal bone. Mechanical testing showed that femoral stiffness was higher in serotonin-dosed animals. The energy absorption also seemed slightly, but not significantly higher. In conclusion, hyperserotoninemia led to a higher BMD, altered bone architecture and higher femural bone stiffness in growing rats, demonstrating that serotonin may have important effects on bone in vivo.
Creating nanocavities of tunable sizes: Hollow helices (2002)

A general strategy for creating nanocavities with tunable sizes based on the folding of unnatural oligomers is presented. The backbones of these oligomers are rigidified by localized, three-center intramolecular hydrogen bonds, which lead to well-defined hollow helical conformations. Changing the curvature of the oligomer backbone leads to the adjustment of the interior cavity size. Helices with interior cavities of 10 A to >30 A across, the largest thus far formed by the folding of unnatural foldamers, are generated. Cavities of these sizes are usually seen at the tertiary and quaternary structural levels of proteins. The ability to tune molecular dimensions without altering the underlying topology is seen in few natural and unnatural foldamer systems.
Addition Compounds of Chromic Anhydride with Some Heterocyclic Nitrogen Bases (1948)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAddition Compounds of Chromic Anhydride with Some Heterocyclic Nitrogen BasesHarry H. Sisler, Jack D. Bush, and Oliver E. AccountiusCite this: J. Am. Chem. Soc. 1948, 70, 11, 3827–3830Publication Date (Print):November 1, 1948Publication History Published online1 May 2002Published inissue 1 November 1948https://pubs.acs.org/doi/10.1021/ja01191a085https://doi.org/10.1021/ja01191a085research-articleACS PublicationsRequest reuse permissionsArticle Views213Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Relationship between Fibrosis and Cancer in Experimental Animals Exposed to Asbestos and Other Fibers (1990)

The association between occupational asbestos exposure and the development of both pulmonary fibrosis or asbestosis and pulmonary carcinomas is well documented. It has been suggested that the two pathological conditions are associated with asbestos-related carcinomas developing from areas of asbestosis and not occurring when exposure has been too low to produce this type of pulmonary scarring. Experimental inhalation studies so far published have not been designed to examine this association specifically, but many publications have reported that asbestos samples producing high levels of fibrosis is experimental animals are also very carcinogenic. Samples of asbestos or man-made fibers that produce little fibrosis also produce few tumors. These works are reviewed. In order to examine the association between fibrosis and tumor production in more detail, groups of animals with and without pulmonary tumors and with individual fibrosis measurements were assembled from a number of inhalation studies undertaken over a period of years at this Institute. It was found that animals with pulmonary tumors had almost double the amount of pulmonary fibrosis as animals of similar age that did not. In a few of the animals where tumors were found at an early stage of development, their origin from fibrotic areas could be confirmed, although in most cases where tumor deposits were widespread this was not possible. Experimental confirmation of the site of origin of most pulmonary tumors in asbestos-treated rats would require new studies with rats examined specifically at an age when early tumors would be expected.
Rearrangements in the second intron of the RARA gene are present in a large majority of patients with acute promyelocytic leukemia and are used as molecular marker for retinoic acid-induced leukemic cell differentiation (1991)

Chromosome 17 breakpoints in translocation t(15;17), a hallmark for acute promyelocytic leukemia (APL), have been shown to disrupt the retinoic acid receptor-alpha (RARA) gene. In this study, DNA probes around the second exon of the RARA gene showed rearrangements not previously detected. Analysis of 25 Chinese APL cases showed that RARA gene rearrangements were present in 23 cases (92%). The breakpoints were mapped unequivocally in 22 cases within the second intron of the gene. Therefore, the RARA gene rearrangement provides us with a specific marker of the disease. Simultaneous molecular and cytologic studies showed that the RARA gene rearrangements persisted during the first 2 to 3 weeks of all-trans retinoic acid (ATRA) therapy when differentiated granulocytes predominated in bone marrow, while these rearrangements disappeared after achieving complete remission. These data indicate that ATRA induces differentiation of APL cells.
Antimalarial Activities of Peptide Antibiotics Isolated from Fungi (2001)

Malaria caused by Plasmodium falciparum is a major public health problem in the developing countries of the world. Clinical treatment of malaria has become complicated due to the occurrence of infections caused by drug resistant parasites. Secondary metabolites from fungi are an attractive source of chemotherapeutic agents. This work reports the isolation and in vitro antiplasmodial activities of peptide antibiotics of fungal origin. The three peptide antibiotics used in this study were efrapeptins, zervamicins, and antiamoebin. The high-performance liquid chromatography-purified peptides were characterized by nuclear magnetic resonance and mass spectral analysis. All three fungal peptides kill P. falciparum in culture with 50% inhibitory concentrations in the micromolar range. A possible mode of action of these peptide antibiotics on P. falciparum is presented.