gebhart/patrepeval huggingface dataset:
Concise Review: Role and Function of the Ubiquitin-Proteasome System in Mammalian Stem and Progenitor Cells (2007)

Highly ordered degradation of cell proteins by the ubiquitin-proteasome system, a sophisticated cellular proteolytic machinery, has been identified as a key regulatory mechanism in many eukaryotic cells. Accumulating evidence reveals that the ubiquitin-proteasome system is involved in the regulation of fundamental processes in mammalian stem and progenitor cells of embryonic, neural, hematopoietic, and mesenchymal origin. Such processes, including development, survival, differentiation, lineage commitment, migration, and homing, are directly controlled by the ubiquitin-proteasome system, either via proteolytic degradation of key regulatory proteins of signaling and gene expression pathways or via nonproteolytic mechanisms involving the proteasome itself or posttranslational modifications of target proteins by ubiquitin or other ubiquitin-like modifiers. Future characterization of the precise roles and functions of the ubiquitin-proteasome system in mammalian stem and early progenitor cells will improve our understanding of stem cell biology and may provide an experimental basis for the development of novel therapeutic strategies in regenerative medicine. Disclosure of potential conflicts of interest is found at the end of this article.
<i>In vitro</i> immunological studies on east african cancer patients. II. Increased sensitivity of blood lymphocytes from untreated burkitt lymphoma patients to inhibition of spontaneous rosette formation (1975)

Frozen aliquots of peripheral blood mononuclear cells from patients with Burkitt's lymphoma (BL) at various stages of the disease have been compared with samples from East African children who were healthy or who suffered from non-malinant disorders. Using the sheep-cell rosette test (which is believed to identify T-lymphocytes), we found a significant reduction in the proportion of rosette-forming cells (RFC) in the samples from untreated BL patients. After reduction of remission the difference between BL patients and controls was abolished. Rosette formation was more readily inhibited by anti-lymphocyte globulin (ALG) in samples from untreated BL patients than in controls. On induction of remission the rosette inhibition curve shifted towards the control values. The findings are compatible with the presence, in untreated BL, of a circulating factor which impairs the capacity of T-lymphocytes to form rosettes with sheep erythrocytes. It remains to be established whether the functional capacity of T-cells to protect the host against tumour proliferation is also impaired.
Office 2007: Top 100 Simplified Tips & Tricks (2007)

You already know Office 2007 basics. Now youre ready to move to the next level, and this book gives you clear, illustrated instructions for 125 tasks that reveal cool secrets, teach timesaving tricks, and explain great tips guaranteed to make you more productive with Office 2007. With minimal text and maximum illustrations, a task-oriented, step-by-step approach, self-contained, two-page lessons for each task, and navigational aids that connect the instructions to their illustrations, its a no-nonsense way to advance your Office skills.
Information management for gaze control in vision guided biped walking (2003)

This article deals with the information management for active gaze control in the context of vision-guided humanoid walking. The proposed biologically inspired predictive gaze control strategy is based on the maximization of visual information. The quantification of the information requires a stochastic model of both, the robot and perception system. The information/uncertainty management, i.e. relationships between the system, state estimation and the active measurements, employs a coupled (considering cross-covariances) hybrid (reflecting the discontinuous character of biped walking) extended (copes with nonlinear systems) Kalman filter approach.
High-fidelity spectroscopy reconstruction in accelerated NMR (2018)

Non-uniform sampling significantly accelerates the data acquisition time in NMR spectroscopy, but spectra must be reconstructed with appropriate methods. A high-fidelity reconstruction method is proposed to preserve low-intensity spectral peaks and provide stable reconstruction under different sampling trials.
Fluorescence Study of the Multiple Binding Equilibria of the Galactose Repressor (1998)

A fluorescence assay has been developed to study the multiple linked equilibria which function in regulation of the Escherichia coli galactose operon. Fluorescein 5-isothiocyanate was attached to Amino-Modifier C6dT at different positions in an oligonucleotide containing the sequence for the OE site of the galactose operon. These fluorescently labeled oligonucleotides were used to study OEDNA-GalR-d-galactose interactions. The data were analyzed and fit to various models including the classical competitive binding model as well as models involving the formation of a ternary DNA-repressor-inducer complex. Examination of the reduced chi-square of the various fits and comparison of fitted parameters with those obtained in independent experiments were used to distinguish different models. Since the ternary complex is likely to exist under physiological conditions, our results suggest that obligatory dissociation of GalR from DNA may not be required for induction of the gal operon. Rather, induction may involve the formation of a ternary complex of OEDNA with GalR and D-galactose with a different conformation than the GalR-OEDNA binary repressor complex.
Mast Cells as Regulators of Skin Inflammation and Immunity (2011)

Mast cells are known to be the effector cells of immediate-type allergy, but experimental evidence obtained during the last decade has revealed their role in innate and acquired immunity. Upon activation mast cells can undergo an anaphylactic or piecemeal degranulation or degranulation-independent mediator secretion, resulting in rapid or slow release of soluble mediators, such as serine proteinases, histamine, lipid-derived mediators, cytokines, chemokines and growth factors. Mast cells can express different receptors and ligands on the cell surface, molecules that can activate the cells of the immune system, such as different subsets of T cells. All these mediators and cell surface molecules can promote inflammation in the skin. During the last years, a new role for mast cells has emerged; induction of tolerance or immunosuppression and interaction with regulatory T cells. However, the mechanisms that switch the proinflammatory function of mast cells to an immunosuppressive one are unknown. In this review, the immunoregulatory function of mast cells and its relation to skin inflammation are discussed.
Cyclotherapy: Protection of Normal Cells and Unshielding of Cancer Cells (2002)

Avoidance of apoptosis and mitogen-independent growth are hallmarks of cancer. Mitogen-activated kinases (for example, ErbB1, Raf-1, MEK, PI-3-K, mTOR) can suppress chemotherapy-induced apoptosis in cancer cells. While kinase inhibitors restore susceptibility of cancer cells to apoptosis, they do not necessarily cause growth arrest in cancer cells harboring additional mutations in downstream signaling pathways such as inactivation of Rb and overexpression of c-myc. This article provides a conceptual basis for a novel use of inhibitors of mitogenic kinases. While arresting growth of normal cells, kinase inhibitors may not arrest cancer cells but instead can sensitize them to apoptosis. Following pretreatment with low doses of kinase inhibitors, the chemotherapy that predominantly induces apoptosis in cycling cells (cyclotherapy) will kill cancer cells while sparing normal cells.
Improved Anatomical Landmark Localization in Medical Images Using Dense Matching of Graphical Models (2010)

We propose a method for reliably and accurately identifying anatomical landmarks in 3D CT volumes based on dense matching of parts-based graphical models. Such a system can be used to establish reliable correspondences in medical images which can be useful on their own or as part of more complex processing e.g. atlas building. We propose and investigate novel methods for efficiently optimizing parameters of appearance models for landmark localization in 3D images. We also investigate the trade-off between the number of model parameters and registration accuracy. We present results for the localization of 22 landmarks in clinical 3D CT volumes of cancer patients and optimization of part-specific patch scales. Over-fitting is likely due to an intrinsically high variability of the data and a limited labeled training and test set, here 83 scans, so we employ a rigorous bootstrap analysis to validate the results. The average mean and maximum registration error over all landmarks is reduced by 31% and 25% for the optimized model, compared to an empirically determined baseline. Additionally, we show a significantly improved performance over standard methods as the number of free parameters increases from an isotropic patch scale shared by all parts, to specific anisotropic patch scales learnt for each part in the model.
Laparoscopic Transillumination for the Location of Anterior Abdominal Wall Blood Vessels (1996)

Superficial abdominal wall vessels may be located by transillumination in the majority of women of normal weight regardless of skin color, but is of less value in overweight and obese women. However, the deep (inferior) epigastric vessels cannot be effectively located by transillumination, and thus other techniques should be used to minimize the risk of injury to these vessels.
Temperature dependence of index of refraction of polymeric waveguides (1992)

The temperature dependence of refractive index of polymer films was determined for a number of slab waveguides by a grating coupling method. This dependence was examined as a function of parameters such as molecular weight and glass transition temperature of the polymer. Temperature-induced changes in N/sub TE/-N/sub TM/, N being the effective index, were studied systematically for different slab waveguide compositions. It is shown that with proper device design and choice of polymeric materials, thermal effects can be reduced.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
<title>Application of multivariate optical computing to simple near-infrared point measurements</title> (2002)

Quantitative multivariate spectroscopic methods seek spectral patterns that correspond to analyte concentrations even in the presence of interferents.By embedding a spectral pattern that corresponds to a target analyte in an interference filter in a beamsplitter arrangement;bulky and complex instrumentation can be eliminated with the goal of producing a field-portable instrument.A candidate filter design for an rganic analyte,of military interest,and an interferent is evaluated.
Fracture characterization and modeling from virtual outcrops (2016)

Advances in virtual outcrop technologies and their introduction to fracture characterization allow extraction of fracture data from very large and inaccessible areas. The recent development of automated or semiautomated methods for fracture extraction aims to reduce or avoid tedious, time-consuming, and biased manual interpretation of fractures from virtual outcrops. We present a benchmarking exercise between a previously proposed automated fracture picking method, manual picking, and fieldwork methods. Comparison between the three methods highlighted their relative advantages and limitations. The automated fracture picking method provided excellent results in terms of fracture orientation, size, spatial distribution, and density. Fieldwork is complementary to fracture extraction from virtual outcrops, and it should focus on quality control of remote sensing data, poorly exposed areas, small-scale observations, diagenesis, timing of fracture development, building conceptual models, and linking fracture stratigraphy to rock properties. We propose a best practice for the use and integration of manual and/or automated fracture extraction from virtual outcrop and fieldwork data for fracture characterization and modeling from outcrop analogs. We consider integration of different methods as the best way to improve the modeling exercise while reducing operational costs and risks.
Identification of three-dimensional objects using range information (1989)

A method for identifying unoccluded three-dimensional objects from arbitrary viewing angles is presented. The technique uses synthetically generated range data in a model-based feature vector classification scheme. Fourier descriptors and moments are used for feature vector generation from, respectively, contour imagery, and silhouette or range imagery. A method is developed for generating an exhaustive set of library views and worst-case test views that is based on a polyhedral approximation to a sphere. Analysis of the success of this approach is made with experiments on a six-airplane data set. A model of range data noise is developed, and results are presented for both ideal and noisy lower-resolution image-classification tests. The use of multiple views for object identification is discussed, and results for one-, two-, and three-view tests are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Subcellular co‐localization of Arabidopsis RTE1 and ETR1 supports a regulatory role for RTE1 in ETR1 ethylene signaling (2007)

Ethylene is an important plant growth regulator perceived by membrane-bound ethylene receptors. The ETR1 ethylene receptor is positively regulated by a predicted membrane protein, RTE1, based on genetic studies in Arabidopsis. RTE1 homologs exist in plants, animals and protists, but the molecular function of RTE1 is unknown. Here, we examine RTE1 expression and subcellular protein localization in order to gain a better understanding of RTE1 and its function in relation to ETR1. Arabidopsis plants transformed with the RTE1 promoter fused to the beta-glucuronidase (GUS) reporter gene revealed that RTE1 expression partly correlates with previously described sites of ETR1 expression or sites of ethylene response, such as the seedling root, root hairs and apical hook. RTE1 transcript levels are also enhanced by ethylene treatment, and reduced by the inhibition of ethylene signaling. For subcellular localization of RTE1, a functional RTE1 fusion to red fluorescent protein (RFP) was expressed under the control of the native RTE1 promoter. Using fluorescence microscopy, RTE1 was observed primarily at the Golgi apparatus and partially at the endoplasmic reticulum (ER) in stably transformed Arabidopsis protoplasts, roots and root hairs. Next, a functional ETR1 fusion to a 5xMyc epitope tag was expressed under the control of the native ETR1 promoter. Immunohistochemistry of root hairs not only showed ETR1 residing at the ER as previously reported, but revealed substantial localization of ETR1 at the Golgi apparatus. Lastly, we demonstrated the subcellular co-localization of RTE1 and ETR1. These findings support and enhance the genetic model that RTE1 plays a role in regulating ETR1.
Even-odd transformation with application to multiuser CW radars (1999)

An even odd transformation is a linear phase transformation which translates a set of sequences into another set, all of whose absolute even (also called periodic) and odd correlation functions become the respective absolute odd and even correlation functions of the original set. This transformation enables the choice of periodic or odd-periodic sequence sets to simplify the implementation of a multiuser CW radar without sacrificing its pulse compression performance. As an application example, the odd-perfect counterparts of the famous Zadoff-Chu sequence sets are derived. Of particular interest is a pair of odd perfect sequences with optimal odd cross-correlation levels, whose phase alphabet size is only half of that of the well-known P3 code for even lengths.
AUSSAT and Communications Policy (1986)

AUSSAT Proprietary Limited is the company, which was formed in 1981 to own and operate the Australian communications satellite system. The Satellite Communications Act 1984 regulates certain aspects of the organisation's operations and it enables the AUSSAT to provide its facilities for use in communication systems for neighbouring regions.
Demand Controlled Ventilation Systems : CO2 Controlled Ventilation Systems (2011)

The subject of the project was a research about the CO2-based demand controlled ventilation. \nThe thesis starts with literature review. The first chapter provides clear understanding of the main concept of CO2-based DCV, required ventilation rates and CO2 differential, information about human breathing and the way it influences the air quality in the interior of the building. In the second chapter there is main benefits of demand controlled ventilation.\nThe third chapter provides CO2 measurement technology. There are two types of sensors to measure CO2 concentration with help of the IR absorption method. The first is non-dispersive infrared (NDIR) absorption sensor and the second is photo-acoustic sensor. In the next chapters are given information about application of demand controlled ventilation, design considerations for demand controlled ventilation, energy efficiency and design example of demand controlled ventilation.\nDCV system controls the amount of outdoor fresh air supply, depending on the number of people in a building and their activity. DCV makes it possible to maintain the needed ventilation and improve indoor air quality while saving energy. Such systems benefit both building operators and building occupants.
Refractive-index measurements of single micron-sized carbon particles (1980)

The differential scattering cross section for single carbon particles is measured in the visible. The data are mathematically inverted to obtain the complex index of refraction and particle radius.
Separation of Metallic and Semiconducting Single-Wall Carbon Nanotube Solution by Vertical Electric Field (2011)

A novel method to separate metallic and semiconducting single-wall carbon nanotubes (SWCNTs) by free solution electrophoresis was investigated. A vertical electrophoretic cell was used to separate SWCNT aqueous solution by the application of electric field along the vertical cell. In contrast with conventional electrophoresis, electric-field-induced layer formation was found in the cell with clear horizontal boundaries. Both the optical absorbance spectra and resonant Raman spectra of these layers revealed the enrichment of metallic and semiconducting SWCNTs with 95% semiconducting SWCNTs in a layer. This method was successfully applied for SWCNTs with diameters from 1.0 to 1.7 nm. Thin-film transistors fabricated by the direct deposition of the semiconductor-enriched nanotubes onto the substrate showed excellent transport properties with an on/off current ratio of 4.4 × 105 and a mobility of 6.8 cm2 V–1 s–1.
Superresolution of ultrasound images using the first and second harmonic signal (2004)

This paper presents a new method of blind two-dimensional (2-D) homomorphic deconvolution and speckle reduction applied to medical ultrasound images. The deconvolution technique is based on an improved 2-D phase unwrapping scheme for pulse estimation. The input images are decomposed into minimum-phase and allpass components. The 2-D phase unwrapping is applied only to the allpass component. The 2-D phase of the minimum-phase component is derived by a Hilbert transform. The accuracy of 2-D phase unwrapping is also improved by processing small (16 x 16 pixels) overlapping subimages separately. This takes the spatial variance of the ultrasound pulse into account. The deconvolution algorithm is applied separately to the first and second harmonic images, producing much sharper images of approximately the same resolution and different speckle patterns. Speckle reduction is made by adding the envelope images of the deconvolved first and second harmonic images. Neither the spatial resolution nor the frame rate decreases, as the common compounding speckle reduction techniques do. The method is tested on sequences of clinical ultrasound images, resulting in high-resolution ultrasound images with reduced speckle noise.
Chlorine Penetration into Artificial Biofilm Is Limited by a Reaction−Diffusion Interaction (1996)

The retarded penetration of chlorine into artificial biofilms of Pseudomonas aeruginosa entrapped in agarose gel slabs was investigated experimentally and shown to be consistent with an unsteady reaction−diffusion model. A chlorine microelectrode was used to measure transient chlorine concentration profiles in artificial biofilms in a flow cell. While chlorine penetrated relatively quickly into pure agarose films (∼15 min), its penetration into biofilms was greatly retarded when cells were present. The degree of retardation was proportional to the initial cell density in the biofilm. After 3 h of treatment with a flowing chlorine solution, the chlorine concentration at the substratum under a 526 μm thick biofilm containing 14 400 mg L-1 cell mass had only risen to 10% of the bulk solution value. A mathematical model of the transient reaction−diffusion interaction correctly captured the qualitative behavior of experimentally measured chlorine concentration profiles. Parameter values for the simulations were obtained from the literature and from independent investigations of biomass−chlorine reactions using well-mixed suspensions. Kinetic and stoichiometric coefficients for the reactions of agarose and cell mass with chlorine were obtained by fitting a simple first-order (in both reactants) kinetic model to chlorine versus time data. The reaction rate coefficient for chlorine−cell reaction (1.1 × 10-3 L mg-1 s-1) exceeded that of chlorine−agarose reaction (3.7 × 10-6 L mg-1 s-1) by 2 orders of magnitude. The yield coefficient relating the amount of cell mass consumed to the amount of chlorine consumed ranged from 0.6 to 4.3 mg mg-1, depending on the duration of the experiment. This study shows that the reaction rate of chlorine with cellular biomass is fast enough that diffusion of this disinfectant into the biofilm readily becomes rate limiting. This reaction−diffusion interaction affords an excellent explanation for the poor efficacy of chlorine when used against biofilm microorganisms.
Reagents for the stepwise functionalization of spermine (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReagents for the stepwise functionalization of spermineR. J. Bergeron and J. S. McManisCite this: J. Org. Chem. 1988, 53, 13, 3108–3111Publication Date (Print):June 1, 1988Publication History Published online1 May 2002Published inissue 1 June 1988https://pubs.acs.org/doi/10.1021/jo00248a037https://doi.org/10.1021/jo00248a037research-articleACS PublicationsRequest reuse permissionsArticle Views3580Altmetric-Citations59LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts