gebhart/patrepeval huggingface dataset:
DeViQ &#x2013; A deep no reference video quality model (2018)

When enjoying video streaming services, users expect high video quality in various situations, including mobile phone connections with low bandwidths. Furthermore, the user's interest in consuming new large-size data content, such as high resolution/frame rate material or 360 degree videos, is gaining as well. To deal with such challenges, modern encoders adaptively reduce the size of the transmitted data. This in turn requires automated video quality monitoring solutions to ensure a sufficient quality of the material delivered. We present a no-reference video quality model; a model that does not require the original reference material, which is convenient for application in the field. Our approach uses a pretrained classification DNN in combination with hierarchical sub-image creation, some state-of-the-art features and a random forest model. Furthermore, the model can process UHD content and is trained on a large ground-truth data set, which is generated using a state-of-the-art full-reference model. The proposed model achieved a high quality prediction accuracy, comparable to a number of full-reference metrics. Thus our model is a proof-of-concept for a successful no-reference video quality estimation.
Whole-field fluorescence microscope with digital micromirror device: imaging of biological samples (2003)

We have developed a whole-field fluorescence microscope equipped with a Digital Micromirror Device to acquire optically sectioned images by using the fringe-projection technique and the phase-shift method. This system allows free control of optical sectioning strength through computer-controlled alteration of the fringe period projected onto a sample. We have employed this system to image viable cells expressing fluorescent proteins and discussed its biological applications.
Bisalkylation Theory of Neoprene Vulcanization (1955)

Abstract Among the organic compounds that are recommended for use with magnesia and zinc oxide as vulcanizing agents for Neoprene are ethylenethiourea (2-imidazolidinethione), p , p ′-diaminodiphenylmethane and the di- o -tolylguanidine salt of dicatechol borate. In the absence of sulfur, these agents in combination with zinc oxide do not vulcanize natural rubber. This points up a marked difference in the way these elastomers vulcanize. Although a major structural difference is the chlorine atom in Neoprene in place of the side methyl group in natural rubber, the small amount of tertiary allylic chlorine formed by 1,2-polymerization is the important functional difference. The labile chlorine amounts to about 1.5 per cent of the total chlorine in a general-purpose Neoprene made at 40° C, such as Neoprene Type W used in this work. In Neoprene latex, this active chlorine is gradually liberated, and the polymer becomes cross-linked. This paper demonstrates the importance of the labile chlorine in the vulcanization of dry Neoprene, accounts for the difference in the vulcanization of Neoprene and natural rubber, and suggests a bisalkylation theory of Neoprene vulcanization.
Prevention of glomerular dysfunction in diabetic rats by treatment with d-alpha-tocopherol. (1997)

Because d-alpha-tocopherol (vitamin E) has been shown to decrease diacylglycerol (DAG) levels and prevent the activation of protein kinase C (PKC), which is associated with retinal and renal dysfunctions in diabetes, the study presented here characterized the effect of d-alpha-tocopherol treatment to prevent glomerular hyperfiltration and increased albuminuria as well as PKC activities in streptozotocin (STZ)-induced diabetic rats. Two weeks after the induction of diabetes, total DAG content and PKC activity in glomeruli were significantly increased in diabetic rats by 106.4 +/- 16.8% and 66.4 +/- 8.4%, respectively, compared with control rats. Intraperitoneal injection of d-alpha-tocopherol (40 mg/kg of body weight) every other day prevented the increases in total DAG content and PKC activity in glomeruli of diabetic rats. Glomerular filtration rate (GFR) and filtration fraction (FF) were significantly elevated to 4.98 +/- 0.34 mL/min and 0.36 +/- 0.05, respectively, in diabetic rats, compared with 2.90 +/- 0.14 mL/min and 0.25 +/- 0.02, respectively, in control rats. These hemodynamic abnormalities in diabetic rats were normalized to 2.98 +/- 0.09 mL/min and 0.24 +/- 0.01, respectively, by d-alpha-tocopherol. Albuminuria in 10-wk diabetic rats was significantly increased to 9.1 +/- 2.2 mg/day compared with 1.2 +/- 0.3 mg/day in control rats, whereas d-alpha-tocopherol treatment improved albumin excretion rate to 2.4 +/- 0.6 mg/day in diabetic rats. To clarify the mechanism of d-alpha-tocopherol's effect on DAG-PKC pathway, the activity and protein levels of DAG kinase alpha and gamma, which metabolize DAG to phosphatidic acid, were examined. Treatment with d-alpha-tocopherol increased DAG kinase activity in the glomeruli of both control and diabetic rats, by 22.6 +/- 3.6% and 28.5 +/- 2.3% respectively, although no differences were observed in the basal DAG kinase activity between control and diabetic rats. Because immunoblotting studies did not exhibit any difference in the protein levels of DAG kinase alpha and gamma, the effect of d-alpha-tocopherol is probably modulating the enzyme kinetics of DAG kinase. These findings suggest that the increases in DAG-PKC pathway play an important role for the development of glomerular hyperfiltration and increased albuminuria in diabetes and that d-alpha-tocopherol treatment could be preventing early changes of diabetic renal dysfunctions by normalizing the increases in DAG and PKC levels in glomerular cells.
Recent development in electrochromic glazings (Invited Paper) (1992)

In this work, optical and electrochemical properties of electrochromic NiOx films are studied. Quartz crystal microbalance study reveals that OH<SUP>-</SUP> insertion/extraction occurs during coloration and bleach reaction of NiOx film in an organic electrolyte. Electrochromic glazings consisting of WO<SUB>3</SUB>/PEO-based Li<SUP>+</SUP> electrolyte/NiOx shows promising solar control properties. The possibility toward NIR-reflectance control is exemplified.
Electron emission from 〈100〉 LaB6 cathodes with large cone angles and flat tips (1984)

This investigation was done to determine the relationship between the arrangement of the crystal faces located at the tip surface of single-crystal 〈100〉 LaB6 cathodes and their emission characteristics from the viewpoint of beam uniformity. The results indicate that as the cone angle of 〈100〉 spherical tip cathodes increases, the angular emission pattern becomes more uniform due to the restriction of the coverage of the crystal faces on the tip and the beam divergence becomes larger. The crystal face appearing on the tip surface is restricted most in flat tip cathodes, and the flat tip cathodes produce a uniformly concentrated angular emission pattern. Because of the strong restriction of the crystal face, the decrease of beam divergence with an increase in emission current is smaller in flat tip cathodes than in spherical tip cathodes. The restriction of the crystal faces appearing on the tip by means of enlarging the cone angle including the flat top is effective in order to obtain uniform electron emission. The brightness of spherical tip cathodes decreases with an increase in the cone angle, while for flat tip cathodes, an increase in the flat surface diameter results in a decrease in brightness.
Efficient modeling and synthesis of on-chip communication protocols for network-on-chip design (2003)

Global on-chip interconnect technology will become the limiting factor for the design of future deep submicron (DSM) SoC. DSM effects, inherent to long interconnects such as unpredictable, large wire delays and non-negligible bit error rates resulting from noise and crosstalk as well as the synchronization between modules with autonomous clock supplies need to be addressed using appropriate on-chip communication schemes. A possible solution is the employment of high-performance single/double wire, packet-oriented, error-concealing communication protocols for on-chip communication. In this paper we propose an efficient design methodology for packet-oriented SoC communication in a SystemC-based design flow. The methodology is based on high level specification, incremental refinement and simulation of a communication protocol in the system context using an extension to SystemC, which follows a high-level synthesis of all interacting protocol controllers in an on-chip network from the initial protocol specification. The methodology was used for implementation of the USB 2.0 protocol for an on-chip communication network.
The Yeast <i>RER2</i> Gene, Identified by Endoplasmic Reticulum Protein Localization Mutations, Encodes <i>cis</i> -Prenyltransferase, a Key Enzyme in Dolichol Synthesis (1999)

As an approach to understand the molecular mechanisms of endoplasmic reticulum (ER) protein sorting, we have isolated yeast rer mutants that mislocalize a Sec12-Mfalpha1p fusion protein from the ER to later compartments of the secretory pathway (S. Nishikawa and A. Nakano, Proc. Natl. Acad. Sci. USA 90:8179-8183, 1993). The temperature-sensitive rer2 mutant mislocalizes different types of ER membrane proteins, suggesting that RER2 is involved in correct localization of ER proteins in general. The rer2 mutant shows several other characteristic phenotypes: slow growth, defects in N and O glycosylation, sensitivity to hygromycin B, and abnormal accumulation of membranes, including the ER and the Golgi membranes. RER2 and SRT1, a gene whose overexpression suppresses rer2, encode novel proteins similar to each other, and their double disruption is lethal. RER2 homologues are found not only in eukaryotes but also in many prokaryote species and thus constitute a large gene family which has been well conserved during evolution. Taking a hint from the phenotype of newly established mutants of the Rer2p homologue of Escherichia coli, we discovered that the rer2 mutant is deficient in the activity of cis-prenyltransferase, a key enzyme of dolichol synthesis. This and other lines of evidence let us conclude that members of the RER2 family of genes encode cis-prenyltransferase itself. The difference in phenotypes between the rer2 mutant and previously obtained glycosylation mutants suggests a novel, as-yet-unknown role of dolichol.
Evidence for degradation of gastrointestinal mucin by Candida albicans secretory aspartyl proteinase (1996)

A zone of extracellular digestion of the mucin layer around Candida albicans blastoconidia was observed by transmission electron microscopy in the jejunum of mice inoculated intragastrically (G. T. Cole, K. R. Seshan, L. M. Pope, and R. J. Yancey, J. Med. Vet. Mycol. 26:173-185, 1988). This observation prompted the hypothesis that a putative mucinolytic enzyme(s) may contribute to the virulence of C. albicans by facilitating penetration of the mucus barrier and subsequent adherence to and invasion of epithelial cells. Mucinolytic activity was observed as zones of clearing around colonies of C. albicans LAM-1 grown on agarose containing yeast nitrogen base, glucose, and hog gastric mucin. In addition, concentrated culture filtrate obtained after growth for 24 h in yeast nitrogen base, supplemented with glucose and mucin as the sole nitrogen source, contained proteolytic activity against biotin-labelled mucin which was inhibited by pepstatin A. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis of the culture filtrate revealed two components of 42 and 45 kDa, with pIs of 4.1 and 5.3, respectively. A zymogram showed that mucin was degraded only by the 42-kDa component, which was also recognized by immunoblotting with an anti-secretory aspartyl proteinase (anti-Sap) 2p monoclonal antibody. The N-terminal sequence of the first 20 amino acids matched that reported for Sap2p. These results demonstrate that Sap2p is responsible for proteolysis of mucin by C. albicans in vitro and may be involved as a virulence factor in the breakdown of mucus and penetration of the mucin barrier by C. albicans.
Polymorphisms in the <i>SCD1</i> Gene: Associations With Body Fat Distribution and Insulin Sensitivity (2007)

Abstract Objective: Obesity and insulin resistance are major risk factors for metabolic diseases and are influenced by lifestyle and genetics. The lipogenic enzyme, stearoyl‐coenzyme A‐desaturase (SCD), is related to obesity. Further, SCD1 ‐deficent mice are protected against obesity and insulin resistance. We hypothesized that genetic polymorphisms in the SCD1 gene would be associated with obesity, insulin sensitivity, and estimated SCD activity in humans. Research Methods and Procedures: The study population was 1143 elderly Swedish men taking part of a population‐based cohort study, the Uppsala Longitudinal Study of Adult Men. Associations between single nucleotide polymorphisms and obesity (waist circumference and BMI), insulin sensitivity (assessed by hyperinsulinemic euglycemic clamp), and estimated SCD activity (fatty acid ratios) were analyzed using linear regression analysis. Results: Subjects homozygous for the rare alleles of rs10883463, rs7849, rs2167444 , and rs508384 had decreased BMI and waist circumference and improved insulin sensitivity. The rare allele of rs7849 demonstrated the strongest effect on both insulin sensitivity [regression coefficient (β) = 1.19, p = 0.007] and waist circumference (β = −4.4, p = 0.028), corresponding to 23% higher insulin sensitivity and 4 cm less waist circumference. Conclusion: This study indicates that genetic variations in the SCD1 gene are associated with body fat distribution and insulin sensitivity, results that accord well with animal data. These results need confirmation in other populations with a larger sample size.
Multiple quantum-well technology takes SEED (1993)

Progress in the development of self-electrooptic-effect devices (SEEDs) is discussed. The devices include the resistor-SEED (R-SEED) device, which can be viewed as a simple NOR gate. The symmetric SEED (S-SEED) and the logic-SEED (L-SEED) devices with improved features, functionality, and performance are also considered. The integration of FETs with multiple quantum well (MQW) modulators (FET-SEED), enables optical interconnections of electronic circuits. Where the SEED technology can be used is discussed, and an experimental optical switching fabric made using these devices is described.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Coverage dependent behavior of redox reaction induced structure change and mass transport at an 11-ferrocenyl-1-undecanethiol self-assembled monolayer on a gold electrode studied by an in situ IRRAS–EQCM combined system (1999)

The potential dependent structure change and mass transport at an 11-ferrocenyl-1-undecanethiol (FcC11SH) self-assembled monolayer on a gold electrode with various coverages were investigated by simultaneous Fourier transform infrared reflection absorption spectroscopy (IRRAS) and electrochemical quartz crystal microbalance (EQCM) measurements in 0.1 M HClO4 solution. As soon as the terminal ferrocene group was oxidized to a ferricenium cation (Fc+), a number of upward and downward IRRAS bands were observed and the surface mass was increased. The intensity of the IRRAS bands corresponded well with the mass change. This behavior is attributed to the redox reaction induced orientation change in the FcC11SH monolayer and ion pair formation between the Fc+ cation and the perchlorate anion in solution. The FcC11SH monolayer with a lower coverage was less stable and was decomposed at a less positive potential than that with a high coverage. Models are proposed to explain the coverage dependent behavior of the FcC11SH monolayer induced by the redox reaction of the terminal ferrocene moiety.
Effect of Nitric Oxide Synthase Inhibitor on Experimentally Induced Burn Wounds (2000)

We concluded that healing of the burn wound is delayed by preventing NO synthesis.
Magneto-Optical Recording Materials (1999)

"As digital data storage technology undergoes enormous change, electrical engineers, physicists, and materials scientists need to keep pace with the materials requirements for recording media. Expert contributors -- together with world-class authorities Richard J. Gambino and Takao Suzuki -- bring you a practical, comprehensive guide to materials design and selection for magneto-optical storage media. This authoritative book explores multilayered thin films, exchanged coupled layers, materials used in current products, and materials of potential interest not yet available in practical applications. A detailed analysis concerning the physics of magneto-optical recording will help you make informed decisions about materials properties. You will also find an extensive discussion of systems and engineering design features for magneto-optical storage devices. This discussion will help you to understand how materials properties impact system performance. You will gain additional insight into this fast-developing field through in-depth coverage of these featured topics: * Rare earth-transition metal amorphous alloys, multilayers, garnets, intermetallic compounds, and ferrites * Basic principles of domain dynamics and recording physics * Latest developments in exchange coupled layers, direct overwrite, and magnetic superresolution * Minidisc, future high-density systems, and DVD format. MAGNETO-OPTICAL RECORDING MATERIALS is essential reading for anyone who needs to keep up-to-date with the latest advances in digital data storage technology."
Selective salient feature based lane analysis (2013)

Lane analysis involves data-intensive processing of input video frames to extract lanes that form a small percentage of the entire input image data. In this paper, we propose lane analysis using selective regions (LASeR), that takes advantage of the saliency of the lane features to estimate and track lanes in a road scene captured by on-board camera. The proposed technique processes selected bands in the image instead of the entire region of interest to extract sufficient lane features for efficient lane estimation. A detailed performance evaluation of the proposed approach is presented, which shows that such selective processing is sufficient to perform lane analysis with a high degree of accuracy.
Characterization of a novel form of X-linked incomplete achromatopsia (2004)

X-linked incomplete achromatopsia (XIA), also called blue-cone monochromacy (BCM), is a rare cone disorder that most commonly results either from one of two conditions. The first condition is a deletion of the locus control region (LCR) which is a critical DNA element that lies upstream of the L and M photopigment gene array on the X-chromosome and is necessary for expression of the photopigment genes. The second condition is an inactivating point mutation within the coding sequence of the remaining photopigment gene in an array from which all but one gene has been deleted. Many previous studies have concluded that affected individuals either have only rods and S-cones (Blackwell & Blackwell, 1957, 1961; Daw & Enoch, 1973; Hess et al., 1989) or have rods, S-cones, and another cone type that contains the rod pigment (Pokorny et al., 1970; Alpern et al., 1971). However, Smith et al. (1983) described individuals with XIA who had residual L-cone function. Here we report results for a subject with XIA who appears to have residual M-cone function. Genetic analysis revealed that he had apparently normal genes for M-cone photopigment thus leaving open the possibility that he has a contribution to vision based on expression of these genes at a very low level.
Single-step synthesis of pyrazoles using titanium catalysis (2011)

A simple titanium complex catalyzes the coupling of alkynes, isonitriles, and monosubstituted hydrazines to generate substituted pyrazoles in a single step.
Abstract 3527: Potent anti-tumor activity of AbGn-100, an anti-CD326 x anti-TCR bispecific antibody to CD326-expressing solid tumors (2012)

Abstract CD326 is one of the first and prominent immunotherapeutic targets in cancer therapy due to its frequent and high-level expression on most carcinomas of various origins. The dominant role of cytotoxic T cells for tumor suppression and surveillance in vivo is well documented in literature. A novel bi-specific antibody AbGn-100 was constructed, in which the antigen-binding domain of an anti- human CD326 antibody was linked to the antigen-binding domain of an anti-human T cell receptor (TCR) ≤ chain antibody. Human serum albumin was incorporated into this construct to prolong the half life in vivo. This bi-specific antibody is able to direct T cells toward CD326-expressing cancer cells to execute T cell cytotoxic function after TCR cross-linking mediated by CD326 expressed on cancer cells while it remains harmless when either T cells or CD326-expressing cancer cells is absent. In vitro cytotoxicity assays with PBMCs from different donors have demonstrated potent (up to 60% above the background) cytotoxicity eliciting activity of AbGn-100 to lung (NCI-H358), ovarian (OMC3) and colorectal (COLO205) cancer cells lines. In the absence of cancer cells, the addition of AbGn-100 didn't trigger the up-regulation of T cell activation markers such as CD25 or CD69, nor did it increase the secretion of cytokines such as IL-2 and Interferon β, demonstrating the safety profile of AbGn-100. In vivo activity of AbGn-100 was tested with established lung (NCI-H358) and ovarian (OMC-3) cancer xenografts in NOD-SCID mice. AbGn-100, in the presence of human PBMC, significantly reduced the size of the established lung and ovarian tumors. Most notably, in some of the mice, tumor was not detectable after 50 days of treatment, suggesting the possibility of tumor eradication. PK studies in mice showed the half-life of AbGn-100 to be around 20 hours, which is substantially longer than conventional single-chain Fv bi-specific antibodies. These data support the potential of further development of AbGn-100 as therapeutics for the treatment of CD326-expressing solid tumors. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3527. doi:1538-7445.AM2012-3527
<i>In Vitro</i>Antibacterial Activity of AZD0914 against Human Mycoplasmas and Ureaplasmas (2015)

In this study, susceptibilities were determined for AZD0914, a spiropyrimidinetrione DNA gyrase inhibitor, azithromycin, doxycycline, and levofloxacin against Mycoplasma and Ureaplasma species. The activity of AZD0914 was comparable to that of levofloxacin and doxycycline against Mycoplasma genitalium and Mycoplasma pneumoniae. The AZD0914 MIC90 against Mycoplasma hominis was 8-fold greater than that for levofloxacin. The AZD0914 MIC90 against Ureaplasma species was 4-fold less than that for azithromycin and 8-fold less than that for levofloxacin and doxycycline.
Fiction and Reality: The Impact of Layoff on Family Structure (2017)

Post-capitalist economy, which is characterized by conditions such as high competition, global circulation of capital and neo-liberal regime, forced organizations to introduce novel types of organizing strategies that aim to promote efficiency and effectiveness. Organizations tend to follow restructuring, downsizing or subcontracting strategies to become more “competitive” that causes high number of laid off and displaced employees. This fact of job loss is strikingly handled by two films. Inspired from these two films, the present study aims to argue the negative impacts of job loss on family. For this aim, in-depth interview was conducted with 8 laid off employees. Findings indicate that long-run unemployment is destructive on family structure. Separation and intent of separation of couples increase by the paternal job loss that also creates role inversion between the partner that results in self-esteem and mental health erosion of patriarch.