gebhart/patrepeval huggingface dataset:
Nonlinear Optical Chromophores for Electro-optical Applications (2010)

The large increase in molecular first hyperpolarizabilities (β) for the thienyl-vinylene bridge based nonlinear optical chromophores by modified acceptor and donor is reported. More than 3.5 times enhancement of βvalue is measured compared to the chromophone without the modification of acceptor and donor. This improvement is further proved by the intrinsic polarizations at zero frequency (β0) converted from β with a two-level model. Furthermore, molecular first hyperpolarizabilities in the molecular can be effectively translated into electro-optic coefficient. The chromophores show the onset docomposition temperatures is above 200°C, indicating that they possessing excellent thermal stability for the electro-optical applications.
Aggressive Flight With Quadrotors for Perching on Inclined Surfaces (2015)

Micro-aerial vehicles (MAVs) face limited flight times, which adversely impacts their efficacy for scenarios such as first response and disaster recovery, where it might be useful to deploy persistent radio relays and quadrotors for monitoring or sampling. Thus, it is important to enable micro-aerial vehicles to land and perch on different surfaces to save energy by cutting power to motors. We are motivated to use a downward-facing gripper for perching, as opposed to a side-mounted gripper, since it could also be used to carry payloads. In this paper, we predict and verify the performance of a custom gripper designed for perching on smooth surfaces. We also present control and planning algorithms, enabling an underactuated quadrotor with a downward-facing gripper to perch on inclined surfaces while satisfying constraints on actuation and sensing. Experimental results demonstrate the proposed techniques through successful perching on a glass surface at various inclinations, including vertical.
Pulmonary arterial hypertension associated with congenital heart disease (2012)

Pulmonary arterial hypertension (PAH) is a common complication of congenital heart disease (CHD), with most cases occurring in patients with congenital cardiac shunts. In patients with an uncorrected left-to-right shunt, increased pulmonary pressure leads to vascular remodelling and dysfunction, resulting in a progressive rise in pulmonary vascular resistance and increased pressures in the right heart. Eventually, reversal of the shunt may arise, with the development of Eisenmenger's syndrome, the most advanced form of PAH-CHD. The prevalence of PAH-CHD has fallen in developed countries over recent years and the number of patients surviving into adulthood has increased markedly. Today, the majority of PAH-CHD patients seen in clinical practice are adults, and many of these individuals have complex disease or received a late diagnosis of their defect. While there have been advances in the management and therapy in recent years, PAH-CHD is a heterogeneous condition and some subgroups, such as those with Down's syndrome, present particular challenges. This article gives an overview of the demographics, pathophysiology and treatment of PAH-CHD and focuses on individuals with Down's syndrome as an important and challenging patient group.
Trends in electro-optical communication systems (1999)

This paper gives an overview of present status and future trends in Electro-optical communication\nsystems and networks. Within the architecture of Electro-optical communication networks, three\nareas with a different type of research focus can be distinguished: the long haul links, the crossconnects and the access networks to the subscribers.
Application identification via network traffic classification (2017)

Recent developments in Internet technology have led to an increased importance of network traffic classification. In this study, we used machine-learning methods for the identification of applications using network traffic classification. Contrary to existing studies, which classify applications into categories like FTP, Instant Messaging, etc., we tried to identify popular end-user applications such as Facebook, Twitter, Skype and many more individually. We are motivated by the fact that individual identification of applications is of high importance for network security, QoS enforcement, and trend analysis. For our tests, we used UNB ISCX Network Traffic dataset and our internal dataset, consisting of 14 and 13 well-known applications respectively. In our experiments, we evaluated four classification algorithms, namely J48, Random Forest, k-NN, and Bayes Net. With the complete set of 111 features, k-NN gave the best result for the ISCX Dataset as 93.94% of accuracy using the value of k as 1, and Random Forest gave the best result for the internal dataset as 90.87% of accuracy. During the course of this study, the initial numbers of features were successfully reduced to two sets of 12 features specific to each dataset without a compromise to the success. Moreover, we observed a 2% increase in the success rate for the internal dataset. We believe that individual application identification by applying machine-learning methods is a viable solution and currently we are investigating a two-tier approach to make it more resilient to in category confusion.
[Evaluation of the efficiency of rapid tests in identifying malaria patients and parasite carriers in the Republic of Tajikistan]. (2013)

The sensitivity of a rapid test versus microscopy ofblood samples was studied while examining 8000 dwellers from the republic's endemic areas. The results of blood testing in the Kumsangir, Dangara, and Vakhdat districts showed agreement with those of blood microscopy. The result of rapid tests did not agree to that of blood microscopy only in one case in the Kabadiyan District. The findings suggest that tests (Care Start b Malaria HPR2/PLDH 2 line test (P.falciparum/P.vivax) COMBO GO161 Access Bio, Inc.) are rather effective and may be further used particularly in remote and Afghanistan-adjacent settlements, as well as among border-guards, in blood transfusion centers and emergency units.
Generating well-shaped Delaunay meshed in 3D (2001)

A triangular mesh in 3D is a decomposition of a given geometric domain into tetrahedra. The mesh is well-shaped if the aspect ratio of every of its tetrahedra is bounded from above by a constant. It is Delaunay if the interior of the circum-sphere of each of its tetrahedra does not contain any other mesh vertices. Generating a well-shaped Delaunay mesh for any 3D domain has been a long term outstanding problem. In this paper, we present an efficient 3D Delaunay meshing algorithm that mathematically guarantees the well-shape quality of the mesh, if the domain does not have acute angles. The main ingredient of our algorithm is a novel refinement technique which systematically forbids the formation of shivers, a family of bad elements that none of the previous known algorithms can cleanly remove, especially near the domain boundary — needless to say, that our algorithm ensure that there is no sliver near the boundary of the domain.
Fidelity of G protein β-subunit association by the G protein γ-subunit-like domains of RGS6, RGS7, and RGS11 (1999)

Several regulators of G protein signaling (RGS) proteins contain a G protein gamma-subunit-like (GGL) domain, which, as we have shown, binds to Gbeta5 subunits. Here, we extend our original findings by describing another GGL-domain-containing RGS, human RGS6. When RGS6 is coexpressed with different Gbeta subunits, only RGS6 and Gbeta5 interact. The expression of mRNA for RGS6 and Gbeta5 in human tissues overlaps. Predictions of alpha-helical and coiled-coil character within GGL domains, coupled with measurements of Gbeta binding by GGL domain mutants, support the contention that Ggamma-like regions within RGS proteins interact with Gbeta5 subunits in a fashion comparable to conventional Gbeta/Ggamma pairings. Mutation of the highly conserved Phe-61 residue of Ggamma2 to tryptophan, the residue present in all GGL domains, increases the stability of the Gbeta5/Ggamma2 heterodimer, highlighting the importance of this residue to GGL/Gbeta5 association.
Channel Sounding of Loaded Reverberation Chamber for Over-the-Air Testing of Wireless Devices: Coherence Bandwidth Versus Average Mode Bandwidth and Delay Spread (2009)

This letter finds the relation between different parameters that characterize the reverberation chamber as a channel emulator for over-the-air (OTA) testing of wireless devices and components. It is shown experimentally for the first time that the coherence bandwidth is proportional to the average mode bandwidth of the chamber. Both coherence bandwidth and average mode bandwidth increase when the chamber is loaded with absorbing objects, and thereby, the reverberation chamber can be controlled to emulate many different real-life environments. The relationship between RMS delay spread and coherence bandwidth are found from the measured channel response and are equal to the theoretical relation for isotropic multipath environments, being within previously published fundamental limits.
Alternating Copolymerization of Propylene Oxide with Biorenewable Terpene‐Based Cyclic Anhydrides: A Sustainable Route to Aliphatic Polyesters with High Glass Transition Temperatures (2015)

The alternating copolymerization of propylene oxide with terpene-based cyclic anhydrides catalyzed by chromium, cobalt, and aluminum salen complexes is reported. The use of the Diels-Alder adduct of α-terpinene and maleic anhydride as the cyclic anhydride comonomer results in amorphous polyesters that exhibit glass transition temperatures (Tg ) of up to 109 °C. The polymerization conditions and choice of catalyst have a dramatic impact on the molecular weight distribution, the relative stereochemistry of the diester units along the polymer chain, and ultimately the Tg of the resulting polymer. The aluminum salen complex exhibits exceptional selectivity for copolymerization without transesterification or epimerization side reactions. The resulting polyesters are highly alternating and have high molecular weights and narrow polydispersities.
Promoter knock-in: a novel rational method for the fine tuning of genes (2010)

We are proposing a novel methodology for obtaining appropriate levels of expression of genes of interest, based on the prediction of the relative strength of selected synthetic promoters combined with an optimized promoter knock-in strategy. The obtained expression levels are independent of the genetic background and scale conditions. The method constitutes therefore a valuable addition to the genetic toolbox for the metabolic engineering of E. coli.
Deep-sea image processing (2005)

High-resolution seafloor mapping often requires optical methods of sensing, to confirm interpretations made from sonar data. Optical digital imagery of seafloor sites can now provide very high resolution and also provides additional cues, such as color information for sediments, biota and divers rock types. During the cruise AT11-7 of the Woods Hole Oceanographic Institution (WHOI) vessel R/V Atlantis (February 2004, East Pacific Rise) visual imagery was acquired from three sources: (1) a digital still down-looking camera mounted on the submersible Alvin, (2) observer-operated 1-and 3-chip video cameras with tilt and pan capabilities mounted on the front of Alvin, and (3) a digital still camera on the WHOI TowCam (Fornari, 2003). Imagery from the first source collected on a previous cruise (AT7-13) to the Galapagos Rift at 86/spl deg/W was successfully processed and mosaicked post-cruise, resulting in a single image covering area of about 2000 sq.m, with the resolution of 3 mm per pixel (Rzhanov et al., 2003). This paper addresses the issues of the optimal acquisition of visual imagery in deep-sea conditions, and requirements for on-board processing. Shipboard processing of digital imagery allows for reviewing collected imagery immediately after the dive, evaluating its importance and optimizing acquisition parameters, and augmenting acquisition of data over specific sites on subsequent dives. Images from the deepsea power and light (DSPL) digital camera offer the best resolution (3.3 Mega pixels) and are taken at an interval of 10 seconds (determined by the strobe's recharge rate). This makes images suitable for mosaicking only when Alvin moves slowly (/spl Lt/1/4 kt), which is not always possible for time-critical missions. Video cameras provided a source of imagery more suitable for mosaicking, despite its inferiority in resolution. We discuss required pre-processing and image enhancement techniques and their influence on the interpretation of mosaic content. An algorithm for determination of camera tilt parameters from acquired imagery is proposed and robustness conditions are discussed.
Crystal Structure of the Transthyretin–Retinoic‐Acid Complex (1995)

Retinoids are quite insoluble and chemically unstable compounds in the aqueous medium, such that natural retinoids need to be bound to specific retinoid-binding proteins to be protected, solubilized and transported in body fluids. All-trans retinoic acid exhibits a relatively high affinity for thyroxine-binding transthyretin in vitro and this protein is a good candidate for the transport of retinoic acid administered as pharmacological or antitumor agent. To define structural features essential for the recognition by transthyretin of a ligand which is structurally unrelated to thyroxine, we have cocrystallized human transthyretin with retinoic acid and determined its structure at 0.18-nm resolution. The retinoid fits into the two chemically identical thyroxine-binding sites, which are located in the central channel that runs through the tetrameric transthyretin. The cyclohexene ring of the bound retinoid is innermost, occupying the same position of the phenolic ring of the bound 3,3'-diiodo-L-thyronine, whereas the carboxylate group, like the same group of the thyroid hormone, participates in an ionic interaction with the Lys15 side chain at the entrance of the channel. Despite the fact that transthyretin was cocrystallized with all-trans-retinoic acid, the isoprene chain of the bound retinoid has been found in a non-extended conformation. This feature, that allows the carboxylate to orient in a manner suitable for ion-pair association with the Lys15 side chain, is attributable to the conversion of all-trans-retinoic acid into cis-isomers or folded conformers. It is concluded that the presence, in an essentially hydrophobic molecular core of the appropriate size, of a negatively charged group at the correct position is a crucial requirement for ligand-transthyretin recognition. Whereas the binding of the ligand has no remarkable consequences for the protein structure, all-trans-retinoic acid undergoes structural changes such as to interact favorably with residues present in the thyroxine-binding sites, resembling roughly the natural ligand.
The importance of context in keeping end users secure (2015)

IT systems are under threat from increasingly severe and sophisticated forms of attack. While the nature of these attacks may have changed over time, along with the motives behind them, the ways in which they are delivered have remained largely the same. Why then, after so many years, are they still able to get through? The recent fundamental changes in the enterprise IT landscape have led to the appearance of new, more complex and more sophisticated threats. There is a growing awareness among enterprise IT security teams of the importance of analytics in providing context around potential threats. This provides the visibility needed to recognise potential threats as soon as they occur, take the necessary remedial action and prevent any further compromise, explains Poul Nielsen of Nexthink.
Shuttle car network for roadway development (2014)

Australian underground coal mines predominately use the longwill method for coal extraction. In longwall mining at least two parallel roadways known as gateroads are mined to delineate the sides of the longwall block, a longwall installation face is then driven connecting the gatheroads to enable the longwall mining equipment to be installed. Roadway development should ideally be ahead of the longwall so that the longwall equipment can be installed into the newly developed panel with minimal delay to coal production. A discrete event mode of roadway development can help asses how a particular configuration may perform with high levels of variability and uncertainty in operations.\nOne of the major delays assoicated with roadway development is caused by the shuttle car due to its cyclic stop-start nature. Shuttle car travelling paths and machine interactions are normally constraint by the mine's roadway layout and mine safety issues. This paper presents simulations of shuttle car route operations which can be considered at the design stage to minimize the cycle time of a shuttle car as part of a general roadway developemnt simulation model developed using 3D flexsim.
Visible and near-infrared bulk optical properties of raw milk (2015)

The implementation of optical sensor technology to monitor the milk quality on dairy farms and milk processing plants would support the early detection of altering production processes. Basic visible and near-infrared spectroscopy is already widely used to measure the composition of agricultural and food products. However, to obtain maximal performance, the design of such optical sensors should be optimized with regard to the optical properties of the samples to be measured. Therefore, the aim of this study was to determine the visible and near-infrared bulk absorption coefficient, bulk scattering coefficient, and scattering anisotropy spectra for a diverse set of raw milk samples originating from individual cow milkings, representing the milk variability present on dairy farms. Accordingly, this database of bulk optical properties can be used in future simulation studies to efficiently optimize and validate the design of an optical milk quality sensor. In a next step of the current study, the relation between the obtained bulk optical properties and milk quality properties was analyzed in detail. The bulk absorption coefficient spectra were found to mainly contain information on the water, fat, and casein content, whereas the bulk scattering coefficient spectra were found to be primarily influenced by the quantity and the size of the fat globules. Moreover, a strong positive correlation (r ≥ 0.975) was found between the fat content in raw milk and the measured bulk scattering coefficients in the 1,300 to 1,400 nm wavelength range. Relative to the bulk scattering coefficient, the variability on the scattering anisotropy factor was found to be limited. This is because the milk scattering anisotropy is nearly independent of the fat globule and casein micelle quantity, while it is mainly determined by the size of the fat globules. As this study shows high correlations between the sample's bulk optical properties and the milk composition and fat globule size, a sensor that allows for robust separation between the absorption and scattering properties would enable accurate prediction of the raw milk quality parameters.
Interplay between bragg- and cavity-mode polaritons in a ZnO microcavity (2009)

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Combining Paclitaxel with ABT-263 Has a Synergistic Effect on Paclitaxel Resistant Prostate Cancer Cells (2015)

We assessed the capability of paclitaxel, one of the taxanes, to induce death in two prostate cancer lines, LNCaP and PC3. Paclitaxel drove an apoptotic pathway in LNCaP, but not in PC3 cells, in response to G2/M arrest. An examination of the levels of anti-apoptotic proteins revealed that Bcl-xl was much higher in PC3 cells than in LNCaP cells and Bcl2 could be detected only in PC3 cells, not in LNCaP cells. Knocking down Bcl-xl enhanced paclitaxel-induced apoptosis in LNCaP cells, while we were unable to knock down Bcl-xl efficiently in PC3 cells. Significantly, a comparison of ABT-263, a specific inhibitor of Bcl2 and Bcl-xl, with ABT-199, a Bcl2 selective inhibitor, disclosed that only ABT-263, not ABT-199, could induce apoptosis in LNCaP and PC3 cells. The results indicate that Bcl-xl has a protective role against paclitaxel-induced apoptosis in LNCaP and PC3 cells, and its overexpression causes the paclitaxel resistance seen in PC3 cells. Interestingly, combined paclitaxel with ABT-263 to treat LNCaP and PC3 cells demonstrated synergistic apoptosis activation, indicating that ABT-263 could enhance paclitaxel-induced apoptosis in LNCaP cells and overcome Bcl-xl overexpression to trigger paclitaxel-induced apoptosis in PC3 cells. We also observed that the activation of apoptosis in LNCaP cells was more efficient than in PC3 cells in response to paclitaxel plus ABT-263 or to ABT-263 alone, suggesting that the apoptosis pathway in PC3 cells might have further differences from that in LNCaP cells even after Bcl-xl overexpression is accounted for.
Thrombospondin signaling through the calreticulin/LDL receptor-related protein co-complex stimulates random and directed cell migration (2003)

The matricellular extracellular matrix protein thrombospondin-1 (TSP1) stimulates focal adhesion disassembly through a sequence (known as the hep I peptide) in its heparin-binding domain. This mediates signaling through a receptor co-complex involving calreticulin and low-density lipoprotein (LDL) receptor-related protein (LRP). We postulate that this transition to an intermediate adhesive state enhances cellular responses to dynamic environmental conditions. Since cell adhesion dynamics affect cell motility, we asked whether TSP1/hep I-induced intermediate adhesion alters cell migration. Using both transwell and Dunn chamber assays, we demonstrate that TSP1 and hep I gradients stimulate endothelial cell chemotaxis. Treatment with focal adhesion-labilizing concentrations of TSP1/hep I in the absence of a gradient enhances endothelial cell random migration, or chemokinesis, associated with an increase in cells migrating, migration speed, and total cellular displacement. Calreticulin-null and LRP-null fibroblasts do not migrate in response to TSP1/hep I, nor do endothelial cells treated with the LRP inhibitor receptor-associated protein (RAP). Furthermore, TSP1/hep I-induced focal adhesion disassembly is associated with reduced chemotaxis to basic fibroblast growth factor (bFGF) but enhanced chemotaxis to acidic (a)FGF, suggesting differential modulation of growth factor-induced migration. Thus, TSP1/hep I stimulation of intermediate adhesion regulates the migratory phenotype of endothelial cells and fibroblasts, suggesting a role for TSP1 in remodeling responses.