gebhart/patrepeval huggingface dataset:
Identification of the receptor scavenging hemopexin-heme complexes (2005)

Heme released from heme-binding proteins on internal hemorrhage, hemolysis, myolysis, or other cell damage is highly toxic due to oxidative and proinflammatory effects. Complex formation with hemopexin, the high-affinity heme-binding protein in plasma and cerebrospinal fluid, dampens these effects and is suggested to facilitate cellular heme metabolism. Using a ligand-affinity approach, we purified the human hemopexin-heme receptor and identified it as the low-density lipoprotein receptor-related protein (LRP)/CD91, a receptor expressed in several cell types including macrophages, hepatocytes, neurons, and syncytiotrophoblasts. Binding experiments, including Biacore analysis, showed that hemopexin-heme complex formation elicits the high receptor affinity. Uptake studies of radio-labeled hemopexin-heme complex in LRP/CD91-expressing COS cells and confocal microscopy of the cellular processing of fluorescent hemopexin-heme complex established the ability of LRP/CD91 to mediate hemopexin-heme internalization resulting in cellular heme uptake and lysosomal hemopexin degradation. Uptake of hemopexin-heme complex induced LRP/CD91-dependent heme-oxygenase 1 mRNA transcription in cultured monocytes. In conclusion, hemopexin-heme complexes are removed by a receptor-mediated pathway showing striking similarities to the CD163-mediated haptoglobin-hemoglobin clearance in macrophages. Furthermore, the data indicate a hitherto unknown role of LRP/CD91 in inflammation.
Epitaxial Manganese Oxide Thin Films with Connected Porosity:  Topotactic Induction of Crystallographic Pore Alignment (2007)

Epitaxial thin films of ZnMn2O4, grown from an aqueous solution on (100) and (111) spinel MgAl2O4 substrates, have been topotactically reduced and leached to produce epitaxial rock salt MnO on the same substrates. The volume change accompanying the conversion of ZnMn2O4 to 2MnO associated with a loss of Zn and O2 manifests as a network of interconnected, 50−100 nm pores. The topotactic nature of the transformation ensures that the pores are crystallographically aligned with the substrate: on the (100) MgAl2O4 substrate, pores with rectangular cross-sections are aligned parallel to the surface normal. On the (111) MgAl2O4 substrate, the pores are aligned at constant, fixed angles with respect to the substrate normal.
SYNTHESIS AND CHARACTERIZATION OF METAL COMPLEXES OF N-(1-PHENYL-3-METHYL-4-BENZAL-5-PYRAZOLONE)-<i>p</i>-METHOXY-BENZOYLHYDRAZINE (2002)

A new tridentate ligand with ONO donor atoms and its complexes have been prepared and characterized on the basis of elemental analyses, IR, UV spectra, thermal analyses and cyclic voltammetry. Spectral data show that the complexes conform to the general experimental formula ML2·nH2O[M˭Mn(II),Co(II),Ni(II),Zn(II), Cd(II);HL˭ N-(1 -phenyl-3-methyl-4-benzal-5-pyrazolone)-p-methoxybenzoylhydrazine.
Modified off-axis unstable resonator for copper vapor laser (1991)

Pointing stability, beam divergence and beam generating mode have been studied in a copper vapor laser equipped with a modified off-axis unstable resonator. In the modified cavity design, the convex mirror is coupled via the edge of a flat scraper mirror, in contrast to the common resonator design where the edge of a convex mirror is used for feedback. As a result, the pointing stability improved, and day to day fluctuations were as small as 200(mu) rad. The beam divergence was about nine times the diffraction limit for the green laser line. The relatively high beam divergence, as well as spatial and temporal analysis of the beam generating mode, shows that a beam traversing the active medium only three times constitutes the useful laser radiation. Possible mechanisms causing the dominance of the triple-pass beam are discussed. An explanation for the impact of the beam generating process on the pointing stability and its improvement in the new cavity design is suggested.
[Increased mortality from esophageal cancer, stomach cancer and skin melanoma in pesticide-exposed pest control operators in the DDR]. (1985)

A retrospective mortality study on male pest control workers of the German Democratic Republic (GDR) was undertaken to evaluate the association of exposure to pesticides and development of malignant tumors. The cohort encompassed 1,214 male subjects with at least 5 years pest control work between 1945 and 1980. Informations on causes of death and cancer cases were obtained from death certificates and the cancer registry form. As control cohort for the standardized mortality ratios (SMR) served the general male population of the GDR. The SMR of 133 for the category of malignant tumors in the pesticide exposed cohort was significantly elevated. Among the other causes of death categories the SMR was less than 100. The tumor excess was statistically significant for the following tumor sites: esophagus, SMR = 430 (4 observed vs. 0.9 expected); stomach, SMR = 180 (14 observed vs. 7.8 expected) and skin melanoma, SMR = 588 (2 observed vs. 0.3 expected). Mortality from stomach cancer showed a linear rising trend by number of years licensed (less than 10 years, SMR = 118; 10-19 = 160; greater than 19 years, SMR = 260). The data suggest an etiological link between the pesticide exposure and increased mortality of esophagus cancer, stomach cancer and skin melanoma.
SIMULTANE AUFZEICHNUNG VON RÖNTGENFERNSEHBILDERN UND DIGITALISIERTEN PHYSIOLOGISCHEN MESSDATEN AUF VIDEOBAND (1976)

Article SIMULTANE AUFZEICHNUNG VON RÖNTGENFERNSEHBILDERN UND DIGITALISIERTEN PHYSIOLOGISCHEN MESSDATEN AUF VIDEOBAND was published on January 1, 1976 in the journal Biomedical Engineering / Biomedizinische Technik (volume 21, issue s1).
Physiological Substrates for Human Lysosomal β-Hexosaminidase S (2002)

Human lysosomal β-hexosaminidases remove terminal β-glycosidically bound <i>N</i>-acetylhexosamine residues from a number of glycoconjugates. Three different isozymes composed of two noncovalently linked subunits α and β exist: Hex A (αβ), Hex B (ββ), and Hex S (αα). While the role of Hex A and B for the degradation of several anionic and neutral glycoconjugates has been well established, the physiological significance of labile Hex S has remained unclear. However, the striking accumulation of anionic oligosaccharides in double knockout mice totally deficient in hexosaminidase activity but not in mice expressing Hex S (Sango, K., McDonald, M. P., Crawley, J. N., Mack, M. L., Tifft, C.J., Skop, E., Starr, C. M., Hoffmann, A., Sandhoff, K., Suzuki, K., and Proia, R. L., (1996)<i>Nat. Genet.</i> 14, 348–352) prompted us to reinvestigate the substrate specificity of Hex S. To identify physiological substrates of Hex S, anionic and neutral oligosaccharides excreted in the urine of the double knockout mice were isolated and analyzed. Using ESI-MS/MS and glycosidase digestion the anionic glycans were identified as products of incomplete dermatan sulfate degradation whereas the neutral storage oligosaccharides were found to be fragments of<i>N</i>-glycan degradation. <i>In vitro</i>, recombinant Hex S was highly active on water-soluble and amphiphilic glycoconjugates including artificial substrates, sulfated GAG fragments, and the sulfated glycosphingolipid SM2. Hydrolysis of membrane-bound SM2 by the recombinant Hex S was synergistically stimulated by the GM2 activator protein and the lysosomal anionic phospholipid bis(monoacylglycero)phosphate.
An all-fiber laser generating cylindrical vector beam (2010)

We proposed and demonstrated an all-fiber laser to generate cylindrical vector beam. A pair of fiber-based collimators was used to select the cylindrical vector beam operating. The radially and azimuthally polarized modes can be switchable just by applying pressure to a section of fiber in our fiber laser system. A 70 cm long Yb-doped fiber was used as gain medium and the lasing wavelength was around 1030 nm.
Plataforma de evaluación automática de programas (2005)

Este articulo describe una plataforma de evaluacion automatica de programas y presenta los resultados obtenidos en su utilizacion para las sesiones practicas (con alumnos frente al computador) de las asignaturas de Lenguaje de Programacion y Redes de Computadores. Se describe la arquitectura de la plataforma asi como tambien la estrategia utilizada en su utilizacion en las asignaturas mencionadas. Se presenta un analisis de los resultados y se discuten los aspectos en los cuales la plataforma apoya la docencia. Finalmente, se exponen las limitaciones de esta forma de evaluacion y se esboza una estrategia para mejorar la metodologia de ensenanza de la programacion.
Structural Characteristics and Classification of Intrinsically Safe Explosion-proof System and Intrinsically Safe Power Supply (2012)

As the concepts of intrinsically safe explosion-proof system and intrinsically safe power supply are easily confused, so it is extremely inconvenience in relevant research and products application. A detailed analysis and discussion were made in categories and characteristics of intrinsically safe explosion-proof system and intrinsically safe power supply. Through summarizing the actual situation of the industrial field, four kinds of intrinsically safe explosion-proof systems structure were established. Structural characteristics and proper location of each type were elaborated interpreted and explained. Primary and secondary intrinsically safe power supply were introduced when including structural system based on the usage occasion and requirements, then the design requires and appropriate condition of them were considered. At the same time, front and back protection mode were presented and their peculiarities were investigated. The purpose of this paper is to contribute to deep comprehension of the concepts of intrinsic safety, to benefit the development and to promote intrinsically safe theory and technology.
Optimized multistandard RF subsampling receiver architecture (2009)

This paper presents a novel subsampling-based down-conversion topology for multistandard radio receiver design. This receiver topology is based on two subsampling stages. The first stage has a fixed RF subsampling frequency; however, the IF sampling frequency of the second stage is variable and depends on the standard being considered. This approach overcomes various undesirable effects related to the sampling frequencies and noise aliasing. By optimizing the choice of the RF subsampling clock frequency, complete multistandard RF bands are down-converted to the same IF band. Quadrature baseband channel downconversion is achieved by a tunable IF sampling frequencies clock. A tunable band-pass RF filter and an IF band-pass filter are designed to perform anti-aliasing and limit wideband noise. A generic design methodology is proposed and validated through its application to a GSM, UMTS and IEEE-802.11g multistandard receiver. Simulation results of this receiver design example confirm the validation of proposed subsampling receiver topology and show the efficiency of the design methodology.
Nontoxic concentrations of PEGylated graphene nanoribbons for selective cancer cell imaging and photothermal therapy (2012)

Reduced graphene oxide nanoribbons functionalized by amphiphilic polyethylene glycol (rGONR–PEG) were applied to attach arginine-glycine-aspartic acid (RGD)-based peptide and cyanine dye 3 (cy3) for targeting ανβ3 integrin receptors on human glioblastoma cell line U87MG and its selective fluorescence imaging, respectively. The rGONR–PEG suspension with a concentration of 100 μg mL−1 showed ∼14 and 2.4-fold higher near infrared (NIR) absorption at 808 nm than GONR (with dimensions of ∼80 nm × 1 μm) and rGO–PEG sheets (with lateral dimensions of ∼2 μm), respectively. The rGONR–PEG–cy3–RGD exhibited highly efficient NIR photothermal therapy performance (concentrations ≥1.0 μg mL−1 resulted in ≥97% cell destruction in vitro under 7.5 W cm−2 NIR irradiation for 8 min). However, the rGONR–PEG exhibited concentration-dependent cyto- and geno-toxicity, so that it initiated at 1.0 μg mL−1 and presented strong effects at concentrations ≥100 μg mL−1 (resulting in >72% cell destruction and >29% DNA fragmentation after 24 h in the dark). Therefore, the concentration of 1.0 μg mL−1 (with <11% cell destruction and 7% DNA fragmentation) is the most effective concentration which can present low cyto- and especially geno-toxic effects. This work can provide insights for simultaneously efficient and biocompatible applications of nano-sized graphene in future photothermal nanotherapy.
Phosphosilicate glass waveguides for phased-array radar time delay (1992)

The design, fabrication, and performance characteristics of passive waveguides and micromechanical switches for use as time delays for phased-array antennas are discussed. The approach considered here is to fabricate the optical waveguides and switches on silicon substrates using VLSI-compatible technology. This approach permits the use of a single off-chip emitter and detector to perform RF-optical and optical-RF conversion for each delay network. It also allows precise lithographic definition of the shorter delay waveguides. Micromechanical waveguide routing switches of two types designed to perform the path selection functions are considered.
Ultraviolet and blue holographic lithography of ZnSe epilayers and heterostructures with feature size to 100 nm and below (1990)

We have employed short-wavelength holographic laser lithography and reactive ion etching to define wire and dot-like patterns in ZnSe thin epitaxial films and heterostructures with spatial feature size to better than 100 nm. Photoluminescence measurements suggest that surface damage from etching may be much less severe than in III-V semiconductors.&lt;hedend&gt;
Throughput of diffraction-limited field optics systems for infrared and millimetric telescopes (1982)

Telescopes for submillimeter wavelengths have point spread functions some millimeters or centimeters in diameter, but the detectors may be only fractions of a millimeter in size. Thus a field aperture and collecting optics are needed. We show how to optimize the aperture by a calculation of the effects of diffraction on signal and resolution as a function of size of the collecting aperture. Our calculations are compared to experimental results from observations of Mars at submillimeter wavelengths.
The dopaminergic response in multiple system atrophy. (1992)

Fifteen of 23 pathologically confirmed cases of multiple system atrophy (MSA) showed some initial response to levodopa and eight of these remained at least partially responsive at the time of death. Eleven developed motor oscillations, and drug-induced dyskinesias, often involving the face and jaw, were also seen in 11 cases. Acute levodopa and apomorphine challenges were administered to 11 patients with clinical MSA who were considered levodopa responsive. A short duration relatively small amplitude response with associated dyskinesias occurred in six and a further three developed dyskinesias without any motor response. Following levodopa withdrawal, a delayed deterioration occurred after three to six days in six patients, five of whom had shown no short duration motor response to the acute challenges. The occurrence of levodopa-induced dyskinesias without a concomitant motor response and delayed deterioration several days after levodopa withdrawal may be more typical of patients with MSA than Parkinson's disease.
Glucosylation of chimeric proteins in the cell wall of <i>Saccharomyces cerevisiae</i> (1994)

Extension of a reporter protein with the carboxyterminal thirty amino acids of the cell wall mannoprotein alpha-agglutinin of Saccharomyces cerevisiae resulted in incorporation of the chimeric protein in the cell wall. By Western analysis it was shown that the incorporated protein contained beta-1,6-glucan similar to endogenous cell wall proteins, whereas excreted reporter protein was not glucosylated. This suggests that beta-1,6-glucan is involved in anchoring mannoproteins in the cell wall.
Cost models for next generation networks with quality of service parameters (2008)

A collection of slides from a conference presentation is given. In particular network dimensioning and network cost estimation based on service parameters are considered.
Synchronized microscanner array for large aperture receiver optics of LIDAR systems (2010)

Traditional laser scanners for 3D distance measurement involve expensive, heavy, (potentially) slow rotating mirrors for light deflection of the scanning TOF (time of flight) distance measurement, not suitable for compact, robust and highly portable LIDAR system. On the other hand MEMS scanners are limited to small apertures not suitable for a precise TOF measurement. To overcome this problem Fraunhofer IPMS presents a large aperture 1D-MEMS scanner array especially designed for LIDAR applications. It is composed of 2 × 7 silicon mirror elements each having an identical design with comparatively large aperture of 2.51 × 9.51mm<sup>2</sup> and ±30° optical scan range. All mirrors are driven electrostatically resonant with identical frequency close to design frequency of 250 Hz. By driving control all single scanner elements are synchronized to identical phase and amplitude in respect to a master scanner. This results in a large effective scanner aperture of 334 mm<sup>2</sup> for the receiver optics and a filling factor of 80 %. To guarantee the synchronized operation the paper discusses in detail the scanner design to enable a sufficiently large frequency bandwidth of all scanner elements to the compensate frequency tolerances caused by fabrication and packaging. In comparison to LIDAR systems with conventional scanner components, the large aperture 1D-MEMS scanner array enables 3D-LIDAR systems to become significantly smaller, more robust and (potentially) less expensive, also higher scan rates can be realized without additional efforts (e.g. no air bearings are needed).
Oxidative stress on EAAC1 is involved in MPTP‐induced glutathione depletion and motor dysfunction (2007)

Excitatory amino acid carrier 1 (EAAC1) is a glutamate transporter expressed on mature neurons in the CNS, and is the primary route for uptake of the neuronal cysteine needed to produce glutathione (GSH). Parkinson's disease (PD) is a neurodegenerative disorder pathogenically related to oxidative stress and shows GSH depletion in the substantia nigra (SN). Herein, we report that 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice, an experimental model of PD, showed reduced motor activity, reduced GSH contents, EAAC1 translocation to the membrane and increased levels of nitrated EAAC1. These changes were reversed by pre-administration of n-acetylcysteine (NAC), a membrane-permeable cysteine precursor. Pretreatment with 7-nitroindazole, a specific neuronal nitric oxide synthase inhibitor, also prevented both GSH depletion and nitrotyrosine formation induced by MPTP. Pretreatment with hydrogen peroxide, L-aspartic acid beta-hydroxamate or 1-methyl-4-phenylpyridinium reduced the subsequent cysteine increase in midbrain slice cultures. Studies with chloromethylfluorescein diacetate, a GSH marker, demonstrated dopaminergic neurons in the SN to have increased GSH levels after NAC treatment. These findings suggest that oxidative stress induced by MPTP may reduce neuronal cysteine uptake, via EAAC1 dysfunction, leading to impaired GSH synthesis, and that NAC would exert a protective effect against MPTP neurotoxicity by maintaining GSH levels in dopaminergic neurons.
Local Delivery of <i>Ox40l</i> , <i>Cd80</i> , and <i>Cd86</i> mRNA Kindles Global Anticancer Immunity (2019)

Localized expression of effector molecules can initiate antitumor responses through engagement of specific receptors on target cells in the tumor microenvironment. These locally induced responses may also have a systemic effect, clearing additional tumors throughout the body. In this study, to evoke systemic antitumor responses, we utilized charge-altering releasable transporters (CART) for local intratumoral delivery of mRNA coding for costimulatory and immune-modulating factors. Intratumoral injection of the CART-mRNA complexes resulted in mRNA expression at the site of administration, transfecting a substantial proportion of tumor-infiltrating dendritic cells, macrophages, and T cells in addition to the tumor cells, resulting in a local antitumor effect. Using a two-tumor model, we further show that mRNA therapy locally administered to one tumor stimulated a systemic antitumor response, curing both tumors. The combination of <i>Ox40l</i>-, <i>Cd80</i>-, and <i>Cd86</i>-encoding mRNA resulted in the local upregulation of proinflammatory cytokines, robust local T-cell activation, and migration of immune cells to local draining lymph node or to an anatomically distant tumor. This approach delayed tumor growth, facilitated tumor regression, and cured tumors in both A20 and CT26 tumor models. These results highlight mRNA-CART therapy as a viable approach to induce systemic antitumor immunity from a single localized injection. SIGNIFICANCE: The mRNA-CART system is a highly effective delivery platform for delivering immunostimulatory genes into the tumor microenvironment for potential therapeutic development.
Review article: the role of gastrointestinal hormones in the treatment of delayed gastric emptying in critically ill patients (2013)

Manipulation of endogenous secretion, physiological replacement and administration of gastrointestinal hormones in pharmacological doses is likely to have therapeutic potential in the treatment of delayed gastric emptying. Future challenges in this field will include the search for candidates with improved selectivity and favourable kinetic properties.
Genotype Distribution of Estrogen Receptor Polymorphisms in Men and Postmenopausal Women From Healthy and Coronary Populations and Its Relation to Serum Lipid Levels (1997)

The cardiovascular protective effects of estrogen are known to be mediated by its beneficial effects on lipid metabolism and its direct actions on the vessel wall. The latter can be mediated by a specific receptor for estrogen present on smooth muscle cells and endothelial cells. The gene for the receptor (the classic estrogen receptor [ER]) has three known polymorphisms, Pvu II, Xba I, and B-variant polymorphisms, which are reportedly associated with receptor expression and altered receptor function and with some disorders including breast cancer, hypertension, and spontaneous abortion. However, the significance of genetic variations of the ER in vascular diseases has not been reported. We have examined the association between coronary artery disease (CAD) and the three polymorphisms in ER. Genotypes (P1/P2, X1/X2, and B-wild type/B-variant type) were determined in 87 men and postmenopausal women with myocardial infarction or angina pectoris whose lesions were confirmed by coronary angiography, as well as from 94 control individuals from the general population with no coronary heart disease and normal resting ECG. For B-variant polymorphism, all individuals examined had B-wild type, which contrasts with the reported allele frequency for B-variant type (0.1) in the white population. Genotype distributions and allele frequencies of Pvu II or Xba I polymorphisms were not significantly different between control subjects and patients (P > .05 for Pvu II or Xba I genotypes; P > .05 for Pvu II or Xba I allele frequencies). When the allele frequencies were analyzed separately by sex, there was still no statistically significant difference for both polymorphisms (P > .05 for men; P > .05 for women). No association was found between the polymorphisms and the angiographic severity of CAD. Total cholesterol, triglyceride, or HDL-cholesterol levels were not significantly different among ER genotypes. These findings suggest that the three polymorphisms in ER are not associated with the prevalence and severity of CAD and that the polymorphisms are unrelated to the serum lipid levels in control subjects and patients.