gebhart/patrepeval huggingface dataset:
Automated Web-Bot Implementation using Machine Learning Techniques in eLearning Paradigm (2014)

E-Learning is very powerful tool and technique that is used to train and educates the people in these days. A lot of world ranking degree awarding universities are begun offer to deliver numerous courses lectures for high school grade education to degree level and even at post-graduation level through eLearning and distance learning paradigm. This research paper extensively concentrates supervised and unsupervised learning methods & strategies which are helpful for the e-Learning framework to automated answer of learners and student inquiries. Primary disadvantage of e-Learning paradigm is not in time answers of learner’s questions, which decrease the learning curve of the student. The key demand in e-Learning environment is to dealing with Machine Learning classification can give higher to learning techniques but not fully automated with this paradigm. Training data set is used form to training the machine and then test data set is used to validate the this approach. This paper analyzes the different machine learning technique and proposed a solution from using these techniques.
Kinetics of the Competitive Degradation of Deoxyribose and other Biomolecules by Hydroxyl Radicals Produced by the Fenton Reaction (1994)

The objective of this work is to reexamine the competitive degradation of deoxyribose by hydroxyl radicals (.OH) produced by the reaction between H2O2 and Fe(2+)-EDTA. The .OH radicals produced attack deoxyribose (D, rate constant kD) and eventually an .OH scavenger (S, rate constant kS). First, we examined the effect of [D], [H2O2], [Fe(2+)-EDTA], [EDTA]/[Fe2+] ratio and reaction time on the rate of D degradation, measured as the absorbance of the chromogen formed between the product of the reaction D + .OH (malondialdehyde) and thiobarbituric acid. In particular, it was showed that under our experimental conditions ([D] = 3 mM, [H2O2] = 0.85 mM, [Fe2+] = 0.13 mM), the rate of overall process is first order in Fe2+, zero order in H2O2 and is maximal for a ratio [EDTA]/[Fe2+] = 1.1. Second, the kinetics of .OH radical reaction in competition experiments between D and S (mannitol) was investigated. The results show that the ratio of the rates of D degradation in the absence (VD) and in the presence (VDS) of S should be represented by VD/VDS = 1 + ks[S]/(kD[D] + kx) where kx accounts for the rate of .OH reactions with other reagents such as Fe(2+)-EDTA, H2O2 etc . . . After having determined kx for each set of experimental conditions, we obtained the values of kS/kD by determining the variations of VD/VDS as a function of [S] and [D]. By taking kD = 1.9 x 10(9) M-1s-1 a value of kS = 1.9 x 10(9) M-1s-1 was obtained, very close to that obtained by pulse radiolysis. Finally, the validity of the established relation was confirmed for other biomolecules (methionine, k = 5.6 x 10(9)M-1s-1 and alanine, k = 3.3 x 10(8) M-1s-1). By contrast, it was not applicable to cysteine, thiourea and mercaptoethanol which was attributed to an interaction of the latter scavengers with Fe2+ and/or H2O2.
A diabetes-associated T-cell autoantigen maps to a telomeric locus on mouse chromosome 6. (1995)

Identification of diabetes-associated T-cell autoantigens is important for understanding the immunopathology of diabetes and developing improved therapeutic strategies. We have used a genetic approach to move toward identifying the autoantigen recognized by a diabetogenic islet-specific T-cell clone from a nonobese diabetic (NOD) mouse. The unique antigen recognition pattern of this clone was utilized to map the gene encoding the antigen (or its expression) by genetic linkage analysis. In vitro analysis of T-cell proliferation by this clone showed that the capacity of the islets to stimulate T cells segregates as a single codominant gene in BALB/cByJ x (BALB/cByJ x NOD/Bdc) backcross mice. This phenotype was tightly linked to two microsatellites in the telomeric region of mouse chromosome 6.
Anionic polymer-coated lipoplex for safe gene delivery into tumor by systemic injection (2013)

In this study, we developed an anionic lipoplex by coating cationic lipoplex with anionic polymers such as hyaluronan (HA), chondroitin sulfate C (CS) and poly-l-glutamic acid (PLE) to deliver the plasmid DNA efficiently into the tumor by avoiding interaction with erythrocytes. The sizes of HA-, CS- and PLE-coated lipoplexes were ∼200 nm and the ζ-potentials were negative. CS- and PLE-coated lipoplexes did not induce agglutination after mixing with erythrocytes, but cationic and HA-coated lipoplexes exhibited agglutination. In terms of biodistribution and gene expression after intravenous administration, cationic and HA-coated lipoplexes largely accumulated and induced gene expression in the lung. In contrast, CS- and PLE-coated lipoplexes did not exhibit high gene expression in the lung and mainly accumulated in the liver. However, in tumor, differences in lipoplex accumulation and gene expression were not observed among the lipoplexes. In terms of toxicity after intravenous injection, CS- and PLE-coated lipoplexes did not increase tumor necrosis factor-α, aspartate aminotransferase and alanine aminotransferase concentrations in blood. From these findings, CS and PLE coatings for cationic lipoplex might produce safe systemic vectors, although they did not increase gene expression in tumor.
Normal ovarian surface epithelial label-retaining cells exhibit stem/progenitor cell characteristics (2008)

Ovulation induces cyclic rupture and regenerative repair of the ovarian coelomic epithelium. This process of repeated disruption and repair accompanied by complex remodeling typifies a somatic stem/progenitor cell-mediated process. Using BrdU incorporation and doxycycline inducible histone2B-green fluorescent protein pulse-chase techniques, we identify a label-retaining cell population in the coelomic epithelium of the adult mouse ovary as candidate somatic stem/progenitor cells. The identified population exhibits quiescence with asymmetric label retention, functional response to estrous cycling in vivo by proliferation, enhanced growth characteristics by in vitro colony formation, and cytoprotective mechanisms by enrichment for the side population. Together, these characteristics identify the label-retaining cell population as a candidate for the putative somatic stem/progenitor cells of the coelomic epithelium of the mouse ovary.
A Universal Mass Detector for Liquid Chromatography (1973)

Journal Article A Universal Mass Detector for Liquid Chromatography Get access W. W. Schulz, W. W. Schulz Search for other works by this author on: Oxford Academic PubMed Google Scholar W. H. King, Jr. W. H. King, Jr. Esso Research and Engineering Company, P.O. Box 121, Linden, New Jersey 07036 Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Chromatographic Science, Volume 11, Issue 7, July 1973, Pages 343–348, https://doi.org/10.1093/chromsci/11.7.343 Published: 01 July 1973 Article history Received: 27 April 1973 Published: 01 July 1973
Ultrasonically guided fine needle puncture of focal liver lesions. Review and personal experience. (1998)

Despite recent advances in diagnostic imaging of the liver, the management of a patient with focal liver lesions often depends on obtaining tissue for histological diagnosis. Ultrasound guided fine needle biopsy is recommended as a safe and reliable method for cyto-histological confirmation of suspected hepatic malignancy. A fine needle is conventionally defined as having an outer diameter < or = 0.9 mm or > or = 19 G. Ultrasound guided fine needle aspiration cytology is found reliable for diagnosing malignancy. Limitations of this method are inadequate sampling and limited value in diagnosis of well-differentiated malignant tumours and benign tumours. Ultrasound guided fine needle cutting biopsy allows to obtain tissue for histological examination according to the Menghini technique. Both methods have high sensitivity, specificity and accuracy in detecting malignancy. In a personal series of 50 fine needle aspiration cytologies, a sensitivity for malignancy of 87% was obtained, with a specificity of 100%. The insufficient sampling rate, however, was 10%. Ultrasound guided fine needle trucut biopsy combines the advantages of a fine needle and a better sampling quality; a lower insufficient sampling rate can be expected without increase in complication rate. Despite the availability of numerous manually operated or (semi-) automated devices, little data have been published up to now on liver lesions. In our hands, it has proven to be a safe and reliable method, with low insufficient sampling rate, allowing correct identification of primary liver malignancies, correct suggestion of the primary source of the majority of metastases and correct identification of most benign liver lesions. Therefore it is considered as the method of choice when focal noncystic liver lesions are to be biopsied.
In vivo microfocal computed tomography and micro–magnetic resonance imaging evaluation of antiresorptive and antiinflammatory drugs as preventive treatments of osteoarthritis in the rat (2010)

Our findings indicate that select combinations of bisphosphonate and NSAID drug therapy in the early stages of secondary OA preserve trabecular bone mass and reduce the impact of osteophytic bony adaptations and bone marrow lesion-like stimulus. Bisphosphonate and NSAID therapy may be an effective disease-modifying drug regimen if administered early after the initial injury.
Angiopoietin-1 is required for Schlemm’s canal development in mice and humans (2017)

Primary congenital glaucoma (PCG) is a leading cause of blindness in children worldwide and is caused by developmental defects in 2 aqueous humor outflow structures, Schlemm's canal (SC) and the trabecular meshwork. We previously identified loss-of-function mutations in the angiopoietin (ANGPT) receptor TEK in families with PCG and showed that ANGPT/TEK signaling is essential for SC development. Here, we describe roles for the major ANGPT ligands in the development of the aqueous outflow pathway. We determined that ANGPT1 is essential for SC development, and that Angpt1-knockout mice form a severely hypomorphic canal with elevated intraocular pressure. By contrast, ANGPT2 was dispensable, although mice deficient in both Angpt1 and Angpt2 completely lacked SC, indicating that ANGPT2 compensates for the loss of ANGPT1. In addition, we identified 3 human subjects with rare ANGPT1 variants within an international cohort of 284 PCG patients. Loss of function in 2 of the 3 patient alleles was observed by functional analysis of ANGPT1 variants in a combined in silico, in vitro, and in vivo approach, supporting a causative role for ANGPT1 in disease. By linking ANGPT1 with PCG, these results highlight the importance of ANGPT/TEK signaling in glaucoma pathogenesis and identify a candidate target for therapeutic development.
Hsp47 and the translation-translocation machinery cooperate in the production of alpha 1(I) chains of type I procollagen. (1994)

Hsp47, an endoplasmic reticulum resident protein, has gelatin-binding and procollagen-binding properties and has been hypothesized to function as a molecular chaperone in regulating procollagen folding and/or assembly. In this report, we further investigate the interaction of Hsp47 with polysome-associated alpha 1(I) procollagen chains following antisense treatment of 3T6 cells. For these studies, we employed phosphorothioate oligodeoxynucleotides directed to the first five codons of Hsp47 that straddle the predicted translation initiation site of mouse Hsp47. Cells depleted of Hsp47 in this manner were observed to produce diminished amounts of fully elongated nascent alpha 1(I) procollagen while accumulating shorter procollagen peptides associated with peptidyl-tRNA. Pulse-labeling of cells with [35S]methionine followed by treatment with puromycin and immunoprecipitation with anti-Hsp47 and anti-procollagen antibodies revealed that Hsp47 is associated with alpha 1(I) procollagen at a very early point during translocation of the nascent procollagen chains. Although Hsp47 appears to possess properties similar to grp78/BiP, Hsp47 binding early during translocation favors a more specialized specific function relative to chain selection or completion of stable folding in type I procollagen.
Natriuretic Peptides for Risk Stratification of Patients with Acute Coronary Syndromes (2004)

Natriuretic peptides (BNP and NT-proBNP) have been shown to be useful tools for risk stratification of patients with acute myocardial ischemia encompassing the whole spectrum of acute coronary syndromes (ACS), particularly for prediction of mortality. Both BNP and NT-proBNP possess several characteristics of the ideal biomarker, showing independent and incremental prognostic value above traditional clinical, electrocardiographic, and biochemical (particularly troponin) risk indicators. Specifically, in ACS patients, BNP and NT-proBNP have powerful prognostic value both in patients without a history of previous heart failure or without clinical or instrumental signs of left ventricular dysfunction on admission or during hospital stay. They can also be easily and rapidly measured in an emergency context. We have performed a meta-analysis of available studies concerning the prognostic value of natriuretic peptides. Our results show that the prognostic value of natriuretic peptides is similar: (1) both at short- and long-term; (2) when natriuretic peptides are measured at first patient contact or during hospital stay; (3) for BNP or NT-proBNP; and (4) in patients with ST elevation myocardial infarction or no ST elevation ACS. These data suggest that natriuretic peptide measurement should be integrated into routine evaluation of patients with an ACS.
Uropathogenic<i>Escherichia coli</i>as Agents of Diverse Non–Urinary Tract Extraintestinal Infections (2002)

Escherichia coli isolates from 3 consecutively encountered patients with serious, invasive, non-urinary tract extraintestinal infections (pneumonia, deep surgical wound infection, and vertebral osteomyelitis with associated epidural/psoas/iliacus abscesses) were characterized, using molecular methods, as to extended virulence genotype and phylogenetic background. All 3 isolates exhibited virulence genotypes and genomic profiles characteristic of specific familiar virulent clones of extraintestinal pathogenic E. coli (ExPEC), which traditionally have been regarded primarily as uropathogenic or as associated with meningitis. These included E. coli O1/O2:K1:H7, E. coli O18:K1:H7, and a recently described E. coli O11/O17/O77:K52:H18 clonal group (clonal group A). These findings demonstrate the extraintestinal pathogenic versatility of ExPEC clones, which supports the use of an inclusive designation for such strains and suggests the possibility of cross-syndrome protective interventions. They also provide novel evidence that multidrug-resistant epidemic clonal group A can cause extraintestinal infections other than uncomplicated urinary tract infections and can cause them in hosts other than young women.
Toward intelligent control (1989)

The problem of automatic tuning of simple regulators is examined. The key idea is to design an aid for the process operator, which should use minimal prior information about the system. This is a typical example of a case where it is essential to develop techniques that will give crude but robust estimates. The development has resulted in a novel generation of the classical PID (proportional, integral, and derivative) controller. An application of relay autotuning to temperature control of a distillation column is considered as an example. Adaptive control is then treated. The adaptive algorithms can be viewed as local gradient methods. They require prior information but, given the information, can give very good control performance. The use of an expert system to integrate the two approaches is then discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Human‐immunodeficiency‐virus transmembrane glycoprotein gp41 is an amino acceptor and donor substrate for transglutaminase <i>in vitro</i> (1993)

Recombinant gp41, the transmembrane glycoprotein of the human-immunodeficiency-virus (HIV) envelope, is an amino acceptor and donor substrate for transglutaminase in vitro. Gln51, Gln52, Gln66 and Lys77 residues were suggested as reactive sites, recognized by the enzyme, for possible cross-linking reactions with gp120, CD4 or other receptor(s) occurring on the surface of HIV-target cells. Soluble CD4, even though unable to function as an amino-acceptor transglutaminase substrate, becomes active in the presence of gp41, negatively influencing the enzyme-catalyzed incorporation of the polyamine spermidine into the transmembrane protein. These results suggest a possible role for transglutaminase in virus entry into host cells, via receptor-mediated endocytosis, and/or in HIV-induced CD4+ T-cell depletion via apoptosis.
Društveni kontekst kriminaliteta i kaznenih djela u globalizirnom svijetu (2013)

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Geister (1985)

Zusammenfassung»Wie Vöglein den Faden nicht sehen, der sie bindet, so waren auch wir beachtet.«
OpenCL-based design methodology for application-specific processors (2010)

OpenCL is a programming language standard which enables the programmer to express the application by structuring its computation as kernels. The OpenCL compiler is given the explicit freedom to parallelize the execution of kernel instances at all the levels of parallelism. In comparison to the traditional C programming language which is sequential in nature, OpenCL enables higher utilization of parallelism naturally available in hardware constructs while still having a feasible learning curve for engineers familiar with the C language. This paper describes methodology and compiler techniques involved in applying OpenCL as an input language for a design flow of application-specific processors. At the core of the methodology is a whole program optimizing compiler that links together the host and kernel codes of the input OpenCL program and parallelizes the result on a customized statically scheduled processor. The OpenCL vendor extension mechanism is used to provide clean access to custom operations. The methodology is studied with a design case to verify the scalability of the implementation at the instruction level and to exemplify the use of custom operations. The case shows that the use of OpenCL allows producing scalable application-specific processor designs and makes it possible to gradually reach the performance of hand-tailored RTL designs by exploiting the OpenCL extension mechanism to access custom hardware operations of varying complexity.
SD-chip enabled quantitative detection of HIV RNA using digital nucleic acid sequence-based amplification (dNASBA) (2018)

Quantitative detection of RNA is important in molecular biology and clinical diagnostics. Nucleic acid sequence-based amplification (NASBA), a single-step method to amplify single-stranded RNA, is attractive for use in point-of-care (POC) diagnostics because it is an isothermal technique that is as sensitive as RT-PCR with a shorter reaction time. However, NASBA is limited in its ability to provide accurate quantitative information, such as viral load or RNA copy number. Here we test a digital format of NASBA (dNASBA) using a self-digitization (SD) chip platform, and apply it to quantifying HIV-1 RNA. We demonstrate that dNASBA is more sensitive and accurate than the real-time quantitative NASBA, and can be used to quantify HIV-1 RNA in plasma samples. Digital NASBA is thus a promising POC diagnostics tool for use in resource-limited settings.
Project Management Success with CMMI: Seven CMMI Process Areas (2007)

Use CMMI to Improve Project Management Efficiency, Effectiveness, and AccountabilityThe Capability Maturity Model Integration (CMMI) Maturity Level 2 offers powerful, end-to-end tools for improvement throughout your organization. In Project Management Success with CMMI®, James Persse demonstrates exactly how to apply CMMI Level 2 to virtually any project, program, or process. User friendly, concise, and easy to follow, this book helps you implement all seven CMMI Level 2 process areas; customize CMMI for your unique projects and organization; and achieve powerful, quantifiable results.The author takes a practical approach to the business and operational needs of project management, carefully linking the realities of business and technical projects with CMMI recommendations. Drawing on his unsurpassed CMMI field experience, Persse presents case studies, anecdotes, and examples-all designed to illuminate what works and what doesn't.Persse introduces the substance and intention of all seven CMMI Level 2 process areas. For each area, he shows how to define goals, implement best practices, understand issues of sizing and scope, and avoid pitfalls and misinterpretations. He is also the first to explain how CMMI can integrate with the tools and skills of the Project Management Institute's Project Management Body of Knowledge, improving the effectiveness of both.Coverage includes Understanding project management as value management Planning projects and structuring expectations Monitoring and controlling projects Managing requirements, configurations, and supplier agreements Implementing effective measurement and analysis Assuring process and product qualityProject Management Success with CMMI® is an invaluable resource for anyone responsible for managing projects, programs, or processes-including those who are new to CMMI and project management.The book's companion Web site (www.prenhallprofessional.com/title/0132333058) contains an extensive library of downloadable CMMI project management resources corresponding to each of the seven CMMI process areas.
Asymptotically Optimal Coding Strategy for L-out-of-K Gaussian Channel using CDMA and successive Decoding (1995)

We introduce a new multiaccess coding strategy called stripping CDMA for a LOOK AWGN channel. Stripping CDMA can be viewed as a generalization of the regular CDMA scheme to one that can achieve arbitrarily high bandwidth efficiency. It can also be viewed as a modification of the pure stripping scheme to one that is suited for multiaccess channel with bursty users. In this scheme, each user is split into M subusers and the decoder consist of M stripping stages using only single-user decoders. All transmitters of all users are identical, making it suitable for bursty user environment where the set of active users is not known in advanced. No synchronization between users at the phase, symbol, or frame level is needed. Although the scheme is only optimal asymptotically in M , it is close to optimal for small M , depending on the bandwidth efficiency. Performance of this scheme using existing non-optimal convolutional code is also investigated. I. Introduction One of the main objectives...
Feature based terrain generation using diffusion equation (2010)

Abstract This paper presents a diffusion method for generating terrains from a set of parameterized curves that characterize the landform features such as ridge lines, riverbeds or cliffs. Our approach provides the user with an intuitive vector‐based feature‐oriented control over the terrain. Different types of constraints (such as elevation, slope angle and roughness) can be attached to the curves so as to define the shape of the terrain. The terrain is generated from the curve representation by using an efficient multigrid diffusion algorithm. The algorithm can be efficiently implemented on the GPU, which allows the user to interactively create a vast variety of landscapes.