gebhart/patrepeval huggingface dataset:
Monocrotaline, an Alternative to Retrorsine-Based Hepatocyte Transplantation in Rodents (2005)

Retrorsine has been used extensively to inhibit proliferation of resident hepatocytes in various transplantation models. Here we report a successful alternative to currently unavailable retrorsine that can be used in cellular transplantation models. Based on structural and molecular similarities, we investigate the use of monocrotaline (MCT) in cell transplantation studies in rodents. In this study, MCT was given to rats intraperitoneally in two injections 2 weeks apart. Two weeks after the final injection, a partial hepatectomy followed by splenic hepatocyte transplantation was performed. The results indicate that MCT, at two doses of 30 mg/kg, highly enhances liver repopulation by donor hepatocytes following partial hepatectomy and produces 15.3 +/- 4.9% liver repopulation within the first 6 weeks following transplantation. Additionally, we tested the effectiveness of MCT in a murine model. Using two injections of 50 mg/kg each, given 2 weeks apart, hepatocyte proliferation in the native liver was inhibited and subsequent oval cell transplants engrafted at 18 +/- 21.3% after 16 weeks posttransplantation. In conclusion, MCT can be used as an effective selective pressure for donor hepatocytes in cell transplantation to the liver in rodents.
Line-Wise Optimal Power Flow Using Successive Linear Optimization Technique (2018)

Optimal power flow (OPF) is an important power systems optimization tool. However, due to the inherent nonlinearity of the solution space, OPF methods may yield a local optimal solution, leading to economic loss. For this reason, an OPF remains a major research topic. Changing power balance equations can change the solution space, alter solution time, and create a chance of reaching a better solution. In this paper, a new simple line-wise optimal power flow (LWOPF) formulation is proposed using line-wise power balance equations and solved using the successive linear programming (SLP) technique. The study results on nine different test systems, up to a 9 241-bus real power system, show that the proposed method is accurate, provides monotonic convergence, scales well for large systems and is consistently faster, up to twice the speed of MATPOWER and other proven bus-wise SLP approaches to solve the OPF.
Speaker identification via support vector classifiers (2002)

A novel approach to speaker identification is presented. The technique, based on Vapnik's (1995) work with support vectors, is exciting for several reasons. The support vector method is a discriminative approach, modeling the boundaries directly between speakers voices in some feature space rather than by the difficult intermediate step of estimating speaker densities. Most importantly, support vector discriminant classifiers are unique in that they separate training data while keeping discriminating power low, thereby reducing test errors. As a result it is possible to build useful classifiers with many more parameters than training points. Furthermore, Vapnik's theory suggests which class of discriminating functions should be used given the amount of training data by being able to determine bounds on the expected number of test errors. Support vector classifiers are efficient to compute compared to other discriminant functions. Though experimental results are preliminary, performance improvements over the BBN modified Gaussian Bayes decision system have been obtained on the Switchboard corpus.
Resource Allocation Techniques in Cloud Computing -- Research Challenges for Applications (2012)

The computational humanity is flattering extremely bulky and multifaceted. Cloud computing is becoming one of the most expanding methodologies in the computing industry. It is a novel approach for the deliverance of IT services on the World Wide Web. This model provides computing resources in the puddle for consumers, all the way through Internet. In cloud computing, resource allocation and scheduling of numerous aggregate web services is an imperative and demanding quandary. This paper estimates the various network resource allocation strategies and their applications in Cloud Computing Environment. A brief description for network resource allocation in Cloud Computing, based on differentially adapted dynamic proportions, has also been done. This paper addresses and categorizes the foremost challenges normal to the resource allocation progress of cloud computing in terms of diverse types of resource allocation techniques.
Single-electron tunneling devices (1998)

Single-electron tunneling devices can detect charges much smaller than the charge of an electron. This enables phenomenally precise charge measurements and it has been suggested that large scale integration of single-electron devices could be used to construct logic circuits with a high device packing density. Here the operation of the two basic types of single-electron tunneling transistors is reviewed. The applications of single-electron tunneling in precision measurements and in general purpose computation is discussed. Particular attention is paid to the characteristics of single-electron tunneling transistors in the superconducting state.
Autonomous collision avoidance for unmanned surface ships using onboard monocular vision (2015)

This study presents the development of vision-based techniques for autonomous collision avoidance by an unmanned surface ship using an onboard monocular camera. In order to determine the initiation of an evasive maneuver, the range and bearing measurements of each target traffic ship with respect to the observer (e.g., own ship) need to be provided for trajectory estimation. A tracking estimator is used to estimate the target ship trajectory in the framework of bearings-only tracking based on the extended Kalman filter (EKF) algorithm with a Continuous White Noise Acceleration (CWNA) model. To enhance the observability of the tracking filter, the vertical pixel distance from the water horizon to each target ship is used as a range measurement. When the estimated separation distance between the target and own ships is less than a predefined minimum separation, the own ship alters its heading angle to avoid an imminent collision following the standard marine traffic rules. Field experiment results are presented and discussed to demonstrate the feasibility and validity of the proposed approach.
Predicting method of contact pressure of fabrics. (1990)

previously developed by the same authors for predicting the spatial form of garment, was extended to estimation of garment pressure. Consideration
Maschinelle Generierung von Aussprachevarianten: Perspektiven für Sprachsyntheseund Spracherkennungssysteme (1989)

Article Maschinelle Generierung von Aussprachevarianten: Perspektiven für Sprachsyntheseund Spracherkennungssysteme was published on June 1, 1989 in the journal it - Information Technology (volume 31, issue 6).
Human Gut-Derived Commensal Bacteria Suppress CNS Inflammatory and Demyelinating Disease (2017)

The human gut is colonized by a large number of microorganisms (∼10<sup>13</sup> bacteria) that support various physiologic functions. A perturbation in the healthy gut microbiome might lead to the development of inflammatory diseases, such as multiple sclerosis (MS). Therefore, gut commensals might provide promising therapeutic options for treating MS and other diseases. We report the identification of human gut-derived commensal bacteria, Prevotella histicola, which can suppress experimental autoimmune encephalomyelitis (EAE) in a human leukocyte antigen (HLA) class II transgenic mouse model. P. histicola suppresses disease through the modulation of systemic immune responses. P. histicola challenge led to a decrease in pro-inflammatory Th1 and Th17 cells and an increase in the frequencies of CD4<sup>+</sup>FoxP3<sup>+</sup> regulatory T cells, tolerogenic dendritic cells, and suppressive macrophages. Our study provides evidence that the administration of gut commensals may regulate a systemic immune response and may, therefore, have a possible role in treatment strategies for MS.
NF-kappa B-like factors mediate interleukin 1 induction of c-myc gene transcription in fibroblasts. (1992)

Interleukin 1 (IL-1) is a pluripotent cytokine involved in mediating a variety of physiological processes, including induction of cell proliferation upon wound healing. Treatment of quiescent FS-4 human dermal fibroblast cells with IL-1 activates c-myc gene transcription, and nuclear localization of NF-kappa B. Previously, we have noted that the murine c-myc gene contains two functional NF-kappa B sites located at -1101 to -1081 bp (upstream regulatory element [URE]) and +440 to +459 bp (internal regulatory element [IRE]) relative to the P1 promoter. Here we have demonstrated that IL-1 treatment induced binding of NF-kappa B-like proteins (p50/p65) to these c-myc elements. Heterologous promoter-CAT constructs driven by multiple copies of either the URE or IRE were IL-1 inducible when transfected into FS-4 cells. In contrast, constructs harboring elements with two G to C residue conversions, such that they were no longer able to bind NF-kappa B, were not responsive to IL-1. Mutation of these two base pairs at both NF-kappa B sites within a c-myc promoter/exon I-CAT construct, resulted in loss of inducibility with IL-1 upon transfection into quiescent FS-4 cells. Thus, IL-1 significantly induces c-myc expression through positive regulation by NF-kappa B, suggesting a role for this family of factors in activation of proliferation associated with wound healing.
A technique for measuring contact force distribution in minimally invasive surgical procedures (1997)

This paper investigates new methods for measuring forces and tactile sense as a contribution towards relaying the sense of touch to the surgeon. The approach used is to determine a distribution of contact force using a small number of sensory outputs to detect the bending of a surface of known behaviour. Software algorithms have been produced to interpret the contacting force from sensory data, and have achieved a bandwidth of 30 Hz and an accuracy of 2 per cent. The sensor construction is of sufficiently low cost to produce a disposable unit and uses materials that are compatible with the invasive working environment.
Radio-frequency plasma reactor for polymer surface treatment (1969)

The design, criteria, construction and operating features of a gaseous plasma reactor to accomplish reactions of partially ionized gases with the surface of polymer substrates, either films or individual parts, is described. The mode of gas excitation is by capacitive electrodeless r.f. energy from conventional r.f. generator sources and impedance matching networks. In this apparatus the conditions within the plasma can be maintained over powers from minimum to 500 w and pressures from several millitorr to several torr. Values of power and pressure can be selected within this range to ensure that the bulk properties of the polymer are not compromized. Internal reflectance infra-red evidence is presented for types of surface reactions that can be produced on several polymer surfaces.
SYNTHESIS OF NOVEL DEGRADABLE POLYMERS FOR TISSUE ENGINEERING BY RADICAL POLYMERIZATION Synthesis and characterization of 2-methylene-1,3-dioxepane and copolymerization thereof with vinyl acetate followed by polymer characterization and hydrolysis (2011)

The commercial field of radical polymerized polymers, such as polyvinyl alcohol, is very broad partly because they are easy to polymerize and cheap. One aspect that could improve their commercial range is to enhance their degradation rate. As the environmental aspect of polymers grows bigger an enhancement of biological degradation is a great improvement. This thesis deals with the prospect of polymerizing polyvinyl alcohol with degradable linkages in the main chain. In order to achieve the aim the monomer 2-methylene-1,3-dioxepane is successfully synthesized and characterized. The synthesis is followed by copolymerization of 2-methylene-1,3-dioxepane with vinylacetate at the feed compositions; 30/70, 50/50, 70/30 mol% respectively. The copolymerization was successful and reached over 90% conversion at the reaction time 3-4 hours with the conditions 60°C and 5mol% 2,2-Azobis(2-methylpropionitrile) as initiator. The copolymerization is followed by hydrolysis with potassium hydroxide or Candida Rugosa Lipase. The results show that chain scission occurs when the polymer is hydrolyzed by potassium hydroxide but not by lipase. There is also a tendency toward hydrolysis of the chain with lipase.
Developmental signaling pathways in brain tumor‐derived stem‐like cells (2007)

Recently, a subpopulation of cells highly efficient in tumor initiation and growth has been isolated from brain tumors. Of interest, these brain tumor initiating cells exhibit many stem-like properties, including self-renewal, extended proliferation, and multipotency, and are both phenotypically and genetically similar to normal neural stem cells (NSCs). Aberrant expression of developmental pathways, such as WNT, Hedgehog, Notch, and transforming growth factor-beta/bone morphogenetic protein, have been demonstrated in brain tumors, and extrinsic regulation of these pathways may be used to target brain tumor stem-like cells (BTSCs) and form the basis of novel biological therapies. Because of regulatory redundancy during normal development, future therapeutic strategies to inhibit BTSC-mediated tumor growth and minimize NSC-related deleterious effects may require detailed understanding and regulation of multiple cellular mechanisms. This review analyzes the role developmental pathways play in brain tumors, focusing on the potential effects of pathway regulation on BTSC-driven tumorigenesis.
Arylation of aromatic heterocycles with arenes and palladium(II) acetate (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTArylation of aromatic heterocycles with arenes and palladium(II) acetateToshio ItaharaCite this: J. Org. Chem. 1985, 50, 25, 5272–5275Publication Date (Print):December 1, 1985Publication History Published online1 May 2002Published inissue 1 December 1985https://pubs.acs.org/doi/10.1021/jo00225a055https://doi.org/10.1021/jo00225a055research-articleACS PublicationsRequest reuse permissionsArticle Views1562Altmetric-Citations103LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Cineradiography in odontology. (1979)

Using cineradiographic equipment with 35 mm film, the application of cineradiographic technique in odontology has been investigated with special reference to observation of bolus-position, the mandibular movement pattern, chewing velocity and the stability of full dentures. The study is divided in two parts. In the first part an assessment is made of the theoretical and practical error of the method and the radiation dose is determined. In the second part limited studies are performed on test-subjects before and after different types of oral rehabilitation. The mathematically estimated geometrical errors almost coincided with the results of the clinical test of the distortion and, together with the tracing error, were of such magnitude that high precision measurements were not possible. By using metal indicators the error could be reduced and movements or differences in the X-ray film greater than 1 mm could be observed with good accuracy. The absorbed dose was determined using the method of thermoluminescent dosimetry and was found to be approximately 5 rad for a cineradiographic investigation of the cranium. The studies of bolus position, mandibular movements etc. revealed, that after oral rehabilitation the patient's oral behaviour may change dramatically. New occlusal surfaces were in most cases used for mastication after a short period of adaptation after rehabilitation. The mandibular movement pattern was also markedly influenced. It is concluded that cineradiography is very suitable for observations of intra-oral behaviour, such as bolus position, and for functional movement analyses. For high-precision measurements other methods should be used.
Endochondral Ossification in Achondroplastic Dwarfism (1970)

The literature concerning endochondral histopathology in the chondrodystrophies is misleading because the true heterogeneity of this group of disorders was not recognized until relatively recently. Accordingly, biopsies of the chondro-osseous junctions of rib and iliac crest were performed on seven typical achondroplastic dwarfs ranging in age from 14 months to 35 years. In contrast to previous reports, histologic studies of this biopsy material demonstrate regular, well organized endochondral ossification in classic achondroplasia. These observations suggest that the basic defect in achondroplasia may be a quantitative decrease in the rate of endochondral ossification, which, in conjunction with undisturbed periosteal bone formation, results in the short, squat shape of the tubular bones. These findings necessitate a reclassification of the many animal chondrodystrophic mutants, some of which have been mislabeled as models of achondroplasia because of their abnormal endochondral histopathology.
EEG-BASED COMMUNICATION BETWEEN MAN AND MACHINE (1997)

Department of Medical Informatics, Institute of Biomedical Engineering Graz University of Technology, Brockmanngasse 41, A-8010 Graz, Austria
High-gain pseudomorphic InGaAs base ballistic hot-electron device (1989)

A high-gain ballistic hot-electron device is described. The GaAs-AlGaAs heterostructure device, with a 21-mm-thick pseudomorphic In/sub 0.12/Ga/sub 0.88/As base, had a current gain of 27 at 77 K and 41 at 4.2 K. As characteristically seen in ballistic devices, transfer into the L valley limited the maximum gain. The Gamma -L valley separation in the strained In/sub 0.12/Ga/sub 0.88/As was estimated to be about 380 meV.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Affinity Improvement of a VEGF Aptamer by <i>in Silico</i> Maturation for a Sensitive VEGF-Detection System (2012)

Systematic evolution of ligands by exponential enrichment (SELEX) is an efficient method to identify aptamers; however, it sometimes fails to identify aptamers that bind to their target with high affinity. Thus, post-SELEX optimization of aptamers is required to improve aptamer binding affinity. We developed in silico maturation based on a genetic algorithm (1) as an efficient mutagenesis method to improve aptamer binding affinity. In silico maturation was performed to improve a VEGF-binding DNA aptamer (VEap121). The VEap121 aptamer is considered to fold into a G-quadruplex structure and this structure may be important for VEGF recognition. Using in silico maturation, VEap121 was mutated with the exception of the guanine tracts that are considered to form the G-quartet. As a result, four aptamers were obtained that showed higher affinity compared with VEap121. The dissociation constant (K(d)) of the most improved aptamer (3R02) was 300 pM. The affinity of 3R02 was 16-fold higher than that of VEap121. Moreover, a bivalent aptamer was constructed by connecting two identical 3R02s through a 10-mer thymine linker for further improvement of affinity. The bivalent aptamer (3R02 Bivalent) bound to VEGF with a K(d) value of 30 pM. Finally, by constructing a VEGF-detection system using a VEGF antibody as the capture molecule and monovalent 3R02 as the detection molecule, a more sensitive assay was developed compared with the system using VEap121. These results indicate that in silico maturation could be an efficient method to improve aptamer affinity for construction of sensitive detection systems.
Thermomechanical Characterization of Shape Memory Polymer–Based Self-Healing Syntactic Foam Sealant for Expansion Joints (2011)

The failure of expansion joints is a leading cause for structural damage to bridge decks and concrete pavements. A fundamental requirement for sealant is that it should always apply a compressive stress to the concrete wall so that adhesive failure can be eliminated; also, the sealant must contract transversely (in the vertical direction) as temperature rises so that the sealant does not squeeze out of the channel. In addition, it is desired that the sealant has some self-healing capabilities so that cohesive failure can be healed. In this study, a shape memory polymer–based (SMP-based) self-healing syntactic foam sealant was prepared and tested. Special two-dimensional (2D) programming or training (compression in one direction and tension in the transverse direction) and free-shape recovery tests were conducted on the foam to evaluate its capability to serve as a sealant for expansion joints. The functional stability of the foam sealant was evaluated by repeated thermomechanical cycles. Furthermore, mechanical properties tests, including uniaxial compression, uniaxial tension, and interfacial shear, were also conducted. Results show that the smart foam sealant can eliminate the squeezing-out problem if programmed properly, and it has the potential to be used in expansion joints.
ELECTROSTATIC HYDRAULIC THREE-WAY GAS MICROVALVE FOR HIGH-PRESSURE APPLICATIONS (2008)

We report an electrostatically-operated micro-hydraulic three-way microvalve, which is capable of operating under high pressure (>50kPa) with high gas conductance (2.03 sccm/kPa). The microvalve is operated by an electrostatically-generated force, which is then hydraulically amplified using DI water as the hydraulic fluid and as a motional valve shutter. The hydraulic microvalve provides (1) high pressure operation due to high electrostatic force provided by the high dielectric constant of DI water (Ɛwater=80), (2) high gas conductance due to large fluidic passages that can be closed/opened using the high deflection actuator, and (3) simple electrical control. It has high gas conductance of 20.3sccm at 10kPa, an electrostatic valve closure against backpressure of >50kPa for a leakage of <10µL/min, an active area of 11.4×9.1mm 2 , and a valve housing (dead) volume of 8.4×6.1×0.03mm 3