gebhart/patrepeval huggingface dataset:
Idle mode for deep power save in IEEE 802.11 WLANs (2010)

Along with the wide acceptance of IEEE 802.11 wireless local area network (WLAN), new applications such as Internet protocol (IP) telephony over WLAN are fast emerging today. For battery-powered IP phone devices, the life time extension is a key concern for the market acceptance while today's 802.11 is not optimized for such an operation. In this paper, we propose a novel idle mode operation, which comprises paging, idle handoff, and delayed handoff. Under the idle mode operation, a mobile host (MH) without any active session does not need to perform hand-off within a predefined paging area (PA). Only when it enters a new PA, an idle handoff is performed. The proposed idle mode allows an MH without traffic to extend its life time. We develop a new analytical model in order to comparatively evaluate our proposed scheme. The numerical results demonstrate that the proposed scheme outperforms the existing schemes with respect to power consumption.
Sealing Technology for Solid Oxide Fuel Cells (SOFC) (2007)

A variety of seals such as metal–metal, metal–ceramic, and ceramic–ceramic are required for a functioning solid oxide fuel cells (SOFC). These seals must function at high temperatures between 600 and 900°C and in oxidizing and reducing environments of the fuels and air. Among the different type of seals, the metal–ceramic and ceramic–ceramic seals require significant attention, research, and development because the brittle nature of ceramics and glasses can lead to fracture and loss of seal integrity and functionality. This paper addresses the needs and possible approaches for high‐temperature ceramic–metal seals for SOFC and seals fabricated using some of these approaches. A new concept of self‐healing glass seals is proposed, developed, and used for making metal—glass–ceramic seals for potential application in SOFC in order to enhance the reliability and life of a cell. In this study, glasses displaying self‐healing behavior are investigated and used to fabricate seals. The performance of these seals under long‐term exposure at higher temperatures coupled with thermal cycling is characterized by leak tests. The self‐healing ability of these glass seals is also demonstrated by leak tests along with the long‐term performance.
A General Method for the Preparation of the D- or L-Stereoisomers of 5-Substituted Hydantoins (1978)

A new procedure for the preparation of optically active 5-substituted hydantoins (5-hydantoins) has been developed. This procedure consists of (I) alkaline hydrolysis of a 5-hydantoin to its corresponding a-amino carboxylic acid, (II) oxidation of either one of the stereoisomers of amino acid with commercially available amino acid oxidase enzymes, (III) isolation of the remaining stereoisomer by ion exchange chromatography, and (IV) resynthesis of the 5-hydantoin by the procedure of Dakin. Because the enzymes utilized in step (II) have very broad substrate specificity, this procedure should be generally applicable to the preparation of optically active 5-hydantoins. As an example, the synthesis of L-5-(4-hydroxy butyl) hydantoin is described, and the optical properties of this previously unresolved compound are reported.
Carboxylation of phenylphosphate by phenol carboxylase, an enzyme system of anaerobic phenol metabolism (1992)

Several lines of evidence indicate that the first step in the anaerobic metabolism of phenol is phenol carboxylation to 4-hydroxybenzoate; this reaction is considered a biological Kolbe-Schmitt carboxylation. A phenol carboxylase system was characterized by using a denitrifying Pseudomonas strain, K 172, which catalyzes an isotope exchange between 14CO2 and the carboxyl group of 4-hydroxybenzoate. The enzymatic isotope exchange activity (100 nmol min-1 mg-1 of protein) requires Mn2+ and K+. We show that this system also catalyzes the carboxylation of phenylphosphate (the phosphoric acid monophenyl ester) to 4-hydroxybenzoate and phosphate. The specific activity of phenylphosphate carboxylation at the optimal pH of 6.5 is 12 nmol of CO2 fixed min-1 mg-1 of protein. Phenylphosphate cannot be replaced by Mg(2+)-ATP and phenol. The carboxylase activity requires Mn2+ but, in contrast to the isotope exchange activity, does not require K+. The apparent Km values are 1.5 mM dissolved CO2 and 0.2 mM phenylphosphate. Several convenient assays for phenylophosphate carboxylation are described. The isotope exchange reaction and the net carboxylation reaction are catalyzed by the same oxygen-sensitive enzyme, which has a half-life in an air-saturated solution of less than 1 min. Both activities cochromatographed with a protein with a Mr of 280,000, and both activities were induced only after anaerobic growth on phenol. The carboxylation of phenylphosphate suggests that phenylphosphate itself is the physiological CO2 acceptor molecular of this novel CO2 fixation reaction. Alternatively, phenylphosphate could simulate the unknown natural precursor. It is suggested that the formation of an enzyme-bound phenolate anion from the activated phenolic compound is the rate-determining step in the carboxylation reaction.
Synthesis of a new sulfonated monomer for poly(aryl ether)s (2005)

Abstract A new sulfonated monomer suitable for polyarylether synthesis was made. 1,1'‐( p ‐Phenylenedioxy)bis[4‐(4‐fluorobenzoyl)]benzene was prepared from phosphorus pentoxide/methanesulfonic acid (PPMA), 1,4‐diphenoxybenzene, and p ‐fluorobenzoic acid in good yield. This compound was selectively monosulfonated on the most activated ring with fuming sulfuric acid and isolated as the sodium salt. Poly(aryl ethers) made from this monomer may find use as proton exchange membranes. © 2005 Wiley Periodicals, Inc. Heteroatom Chem 16:553–556, 2005; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/hc.20137
Migrant families and churches (2015)

The flood of refugees from Syria is pulling at the heart-strings of the world. Many hundreds of thousands of people are fleeing war and the death, destruction and poverty that goes with it. For many of these refugees, the physical journey out of Syria is just one stage in what will be a social journey of generations, as they assimilate into their new places of residence. The churches and other religious organisations play a significant role in that journey. Past articles in Pointers have explored the demographic dimensions of immigration to Australia (Hughes 2012). Recent research has involved conversations with members of immigrant families to understand better the roles of the church and how they can both help and hinder migrant and refugee families as they settle into Australian society.
Foreign Portfolio versus Foreign Direct Investment Flows: Are They So Different? (2011)

Many emerging economies in Asia and elsewhere have been faced with sharply volatile capital flows, mainly driven by sharp booms and busts in foreign portfolio and short-term bank flows, together referred to as “mobile capital”. In contrast, FDI flows have remained remarkably stable (see Chapter 20). The policy focus on this “mobile capital” has tried to limit such flows via capital account restrictions or through prudential measures, or by ensuring that the central bank holds enough low-yielding liquid assets (i.e. foreign exchange reserves) to cover possible sudden withdrawals.
The potential role of Bismide alloys in future photonic devices (2011)

In a similar manner to the dilute nitrides, the incorporation of Bismuth in semiconductors such as GaAs is predicted to lead to a band-anti-crossing effect (in the valence band) causing a large band gap bowing. In addition, the large size of Bismuth atoms gives rise to a large spin-orbit splitting. This opens-up interesting new possibilities for efficient photonic devices, such as near- and mid-infrared lasers which are more thermally stable and less susceptible to losses compared to conventional InP-based devices. Since Bismuth principally influences the valence band, while nitrogen influences the conduction band, combining Bismuth and Nitrogen in III-V alloys offers huge potential for engineering the conduction and valence band offsets, the band gap and spin-orbit splitting, with wide scope for the design of photonic devices.
Signaling pathways in phagocytosis (1999)

Phagocytosis is an uptake of large particles governed by the actin-based cytoskeleton. Binding of particles to specific cell surface receptors is the first step of phagocytosis. In higher Eucaryota, the receptors able to mediate phagocytosis are expressed almost exclusively in macrophages, neutrophils, and monocytes, conferring immunodefence properties to these cells. Receptor clustering is thought to occur upon particle binding, that in turn generates a phagocytic signal. Several pathways of phagocytic signal transduction have been identified, including the activation of tyrosine kinases and (or) serine/threonine kinase C in pivotal roles. Kinase activation leads to phosphorylation of the receptors and other proteins, recruited at the sites of phagocytosis. Monomeric GTPases of the Rho and ARF families are likely to be engaged downstream of activated receptors. The GTPases, in cooperation with phosphatidylinositol 4-phosphate 5-kinase and phosphatidylinositol 3-kinase lipid modifying enzymes, can modulate locally the assembly of the submembranous actin filament system leading to particle internalization.
Use of Continuous Venovenous Hemodiafiltration to Enhance the Elimination of Serum Pentobarbital before Diagnosis of Brain Death (2012)

Continuous venovenous hemodiafiltration (CVVHDF) was used to eliminate pentobarbital from the blood of a 30-year-old potentially brain dead male patient with traumatic intracranial hemorrhage after a motorcycle accident. The Acute Physiology and Chronic Health Evaluation (APACHE) II score of hospital day 1 was 24, but by day 8 it was 36, when the patient was considered to be brain dead. To control seizures and reduce intracranial pressure, pentobarbital had been administered in a continuous flow (2,880 mg/day for 5 days). Coma can be induced by pentobarbital at a serum level of 15 mg/dL. However, drug intoxication should be excluded from a brain death evaluation; therefore, the patient was not given any drug for approximately 88 hrs after ceasing pentobarbital in order for serum level to dip below 0.5 mg/dL (which is the hypnotic level). At 48 hours from CVVHDF, the pentobarbital level was close to the hypnotic level (0.10.5 mg/dL). Before stopping, the serum level of pentobarbital was 3.89 mg/dL and between 48 and 72 hours from CVVHDF, 4 cycles of pentobarbital half-life elimination (0.24 mg/dL) could be measured. Therefore, we suggest that in case of potential brain dead patients who have been administered pentobarbital, CVVHDF can enhance the elimination of pentobarbital from the circulatory system and shorten the waiting time for a brain death evaluation.
Glycine receptor autoantibodies disrupt inhibitory neurotransmission (2019)

Chloride-permeable glycine receptors have an important role in fast inhibitory neurotransmission in the spinal cord and brainstem. Human immunoglobulin G (IgG) autoantibodies to glycine receptors are found in a substantial proportion of patients with progressive encephalomyelitis with rigidity and myoclonus, and less frequently in other variants of stiff person syndrome. Demonstrating a pathogenic role of glycine receptor autoantibodies would help justify the use of immunomodulatory therapies and provide insight into the mechanisms involved. Here, purified IgGs from four patients with progressive encephalomyelitis with rigidity and myoclonus or stiff person syndrome, and glycine receptor autoantibodies, were observed to disrupt profoundly glycinergic neurotransmission. In whole-cell patch clamp recordings from cultured rat spinal motor neurons, glycinergic synaptic currents were almost completely abolished following incubation in patient IgGs. Most human autoantibodies targeting other CNS neurotransmitter receptors, such as N-methyl-d-aspartate (NMDA) receptors, affect whole cell currents only after several hours incubation and this effect has been shown to be the result of antibody-mediated crosslinking and internalization of receptors. By contrast, we observed substantial reductions in glycinergic currents with all four patient IgG preparations with 15 min of exposure to patient IgGs. Moreover, monovalent Fab fragments generated from the purified IgG of three of four patients also profoundly reduced glycinergic currents compared with control Fab-IgG. We conclude that human glycine receptor autoantibodies disrupt glycinergic neurotransmission, and also suggest that the pathogenic mechanisms include direct antagonistic actions on glycine receptors.
The low affinity glucose transporter HxtB is also involved in glucose signalling and metabolism in Aspergillus nidulans (2017)

One of the drawbacks during second-generation biofuel production from plant lignocellulosic biomass is the accumulation of glucose, the preferred carbon source of microorganisms, which causes the repression of hydrolytic enzyme secretion by industrially relevant filamentous fungi. Glucose sensing, subsequent transport and cellular signalling pathways have been barely elucidated in these organisms. This study therefore characterized the transcriptional response of the filamentous fungus Aspergillus nidulans to the presence of high and low glucose concentrations under continuous chemostat cultivation with the aim to identify novel factors involved in glucose sensing and signalling. Several transcription factor- and transporter-encoding genes were identified as being differentially regulated, including the previously characterized glucose and xylose transporter HxtB. HxtB was confirmed to be a low affinity glucose transporter, localizing to the plasma membrane under low- and high-glucose conditions. Furthermore, HxtB was shown to be involved in conidiation-related processes and may play a role in downstream glucose signalling. A gene predicted to encode the protein kinase PskA was also identified as being important for glucose metabolism. This study identified several proteins with predicted roles in glucose metabolic processes and provides a foundation for further investigation into the response of biotechnologically important filamentous fungi to glucose.
An Analysis of the Effect of Laser Beam Geometry on Laser Transformation Hardening (2005)

The effect of transformation hardening depends upon both heating and cooling rates. It is desirable to have a slow heating rate and a rapid cooling rate to achieve full transformation. To date laser transformation hardening has been carried out using circular or rectangular beams which result in rapid heating and cooling. Although the use of different beam intensity distributions within the circular or rectangular laser beams has been studied to improve the process, no other beam geometries have been investigated so far for transformation hardening. This paper presents an investigation into the effects of different laser beam geometries in transformation hardening. Finite element modeling technique has been used to simulate the steady state and transient effects of moving beams in transformation hardening of EN 43A steel. The results are compared with experimental data. The work shows that neither of the two commonly used beams, circular and rectangular, are optimum beam shapes for transformation hardening. The homogenization temperature exceeds the melting point for these beam shapes for the usual laser scanning speeds and power density. Triangular beam geometry has been shown to produce the best thermal history to achieve better transformation and highest hardness due to slower heating without sacrificing the processing rate and hardening depths.
Thermodynamic data for the binding of molecular oxygen to cobalt(II) protoporphyrin IX dimethyl ester (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThermodynamic data for the binding of molecular oxygen to cobalt(II) protoporphyrin IX dimethyl esterTony J. Beugelsdijk and Russell S. DragoCite this: J. Am. Chem. Soc. 1975, 97, 22, 6466–6472Publication Date (Print):October 1, 1975Publication History Published online1 May 2002Published inissue 1 October 1975https://pubs.acs.org/doi/10.1021/ja00855a028https://doi.org/10.1021/ja00855a028research-articleACS PublicationsRequest reuse permissionsArticle Views174Altmetric-Citations39LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Probabilistic Timing Join over Uncertain Event Streams (2006)

This paper addresses the problem of processing eventtiming queries over event streams where the uncertainty in the values of the timestamps is characterizable by histograms. We describe a stream-partitioning technique for checking the satisfaction of a probabilistic timing constraint upon event arrivals in a systematic way in order to delimit the "probing range" in event streams. This technique can be formalized as a probabilistic timing join (PTJoin) operator where the join condition is specified by a time window and a confidence threshold in our model. We present efficient PTJoin algorithms that tightly delimit the probing range and efficiently invalidate events in event streams.
Compatibility Pays Off (1989)

An executive at Arthur D. Little, Inc., the country's oldest management consulting firm, provides some answers to the question, “What will I get when I hire a consultant?”
Polyester Scaffolds with Bimodal Pore Size Distribution for Tissue Engineering (2006)

This paper presents a method for the preparation of porous poly(L-lactide)/poly[(L-lactide)-co-glycolide] scaffolds for tissue engineering. Scaffolds were prepared by a mold pressing-salt leaching technique from structured microparticles. The total porosity was in the range 70-85%. The pore size distribution was bimodal. Large pores, susceptible for osteoblasts growth and proliferation had the dimensions 50-400 microm. Small pores, dedicated to the diffusion of nutrients or/and metabolites of bone forming cells, as well as the products of hydrolysis of polyesters from the walls of the scaffold, had sizes in the range 2 nm-5 microm. The scaffolds had good mechanical strength (compressive modulus equal to 41 MPa and a strength of 1.64 MPa for 74% porosity). Scaffolds were tested in vitro with human osteoblast-like cells (MG-63). It was found that the viability of cells seeded within the scaffolds obtained using the mold pressing-salt leaching technique from structured microparticles was better when compared to cells cultured in scaffolds obtained by traditional methods. After 34 d of culture, cells within the tested scaffolds were organized in a tissue-like structure. Photos of section of macro- and mesoporous PLLA/PLGA scaffold containing 50 wt.-% of PLGA microspheres after 34 d of culture. Dark spots mark MG-63 cells, white areas belong to the scaffold. The specimen was stained with haematoxylin/eosin. Bar = 100 microm.
ESTIMATION OF AVERAGE HETEROZYGOSITY AND GENETIC DISTANCE FROM A SMALL NUMBER OF INDIVIDUALS (1978)

The magnitudes of the systematic biases involved in sample heterozygosity and sample genetic distances are evaluated, and formulae for obtaining unbiased estimates of average heterozygosity and genetic distance are developed. It is also shown that the number of individuals to be used for estimating average heterozygosity can be very small if a large number of loci are studied and the average heterozygosity is low. The number of individuals to be used for estimating genetic distance can also be very small if the genetic distance is large and the average heterozygosity of the two species compared is low.
Strong coupling in high-finesse organic semiconductor microcavities (2003)

We report the fabrication of high-finesse strongly coupled microcavities composed of a polystyrene film doped with the dye tetraphenyl–porphyrin zinc positioned between two high reflectivity dielectric mirrors. The bottom mirror was deposited by plasma enhanced chemical vapor deposition, and was composed of 11 λ/4 thick (silicon oxide/silicon nitride) pairs. The organic layer was deposited on to this by spin coating. Finally, the top mirror was deposited by thermal evaporation and consisted of 12 λ/4 thick (tellurium oxide/lithium fluoride) pairs. Such cavities are characterized by Q factors of between 440 and 620. Strong coupling was evidenced via white light reflectivity measurements. Due to the high cavity Q factor, a Rabi splitting of 135 meV at resonance was very clearly resolved.
Breast Cancer Policymaking (2000)

Breast cancer policy can be defined as the set of decisions made by society to allocate resources to research, programs, and services to prevent and treat breast cancer. The fact that we now recognize the existence of national breast cancer policymaking means that there has been a process of constructing breast cancer as a social problem, of formulating alternative approaches to addressing the problem through public policy, and of making social choices among policy options. Various groups have participated in this process, including legislators and government agencies, professional associations, private industry, and citizen interest groups organized to advocate for breast cancer causes. Furthermore, because breast cancer is primarily an illness of women, gender issues have been central to its politics.
Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8 (2003)

GPR7 and GPR8 are orphan G protein-coupled receptors that are highly similar to each other. These receptors are expressed predominantly in brain, suggesting roles in central nervous system function. We have purified an endogenous peptide ligand for GPR7 from bovine hypothalamus extracts. This peptide, termed neuropeptide B (NPB), has a C-6-brominated tryptophan residue at the N terminus. It binds and activates human GPR7 or GPR8 with median effective concentrations (EC(50)) of 0.23 nM and 15.8 nM, respectively. In situ hybridization shows distinct localizations of the prepro-NPB mRNA in mouse brain, i.e., in paraventricular hypothalamic nucleus, hippocampus, and several nuclei in midbrain and brainstem. Intracerebroventricular (i.c.v.) injection of NPB in mice induces hyperphagia during the first 2 h, followed by hypophagia. Intracerebroventricular injection of NPB produces analgesia to s.c. formalin injection in rats. Through EST database searches, we identified a putative paralogous peptide. This peptide, termed neuropeptide W (NPW), also has an N-terminal tryptophan residue. Synthetic human NPW binds and activates human GPR7 or GPR8 with EC(50) values of 0.56 nM and 0.51 nM, respectively. The expression of NPW mRNA in mouse brain is confined to specific nuclei in midbrain and brainstem. These findings suggest diverse physiological functions of NPB and NPW in the central nervous system, acting as endogenous ligands on GPR7 andor GPR8.