gebhart/patrepeval huggingface dataset:
New approaches to the treatment of depression. (1996)

This review considers the various modes of action and possible advantages of the different types of second generation antidepressants. The biochemical changes that may be causally related to depression and the mechanisms whereby these changes may be attenuated by antidepressant treatment are briefly considered. Whereas the monoamine theory of depression and the receptor adaptation hypothesis of antidepressant action have been influential in helping to unify the mechanisms of action of antidepressants with the possible pathologic basis of depression, the introduction of novel antidepressants and the development of treatment strategies suggestive of a rapid onset of antidepressant response may initiate a revision of these concepts. The review ends with a consideration of the nonaminergic changes that may be of fundamental importance not only in the pathologic basis of depression but also to the means whereby antidepressants bring about their clinical effects.
Electrospinning: A Simple and Versatile Technique for Producing Ceramic Nanofibers and Nanotubes (2006)

Electrospinning is a remarkably simple method for generating nanofibers of polymers. When combined with conventional sol–gel processing, it provides a versatile technique for producing ceramic nanofibers with either a solid, porous, or hollow structure. This article presents a brief overview of recent progress in preparation of ceramic nanofibers by electrospinning, with a focus on an introduction to experimental procedures and analysis of several technical issues that are vital for a successful electrospinning experiment. We also highlight the unique capabilities of this technique in processing ceramic materials into nanostructures, and illustrate some potential applications of these nanostructures.
Assessing the benefits of using mate-pairs to resolve repeats in de novo short-read prokaryotic assemblies (2011)

Our results demonstrate that dramatic improvements in prokaryotic genome assembly quality can be achieved by tuning mate-pair sizes to the actual repeat structure of a genome, suggesting the possible need to change the way sequencing projects are designed. We propose that a two-tiered approach - first generate an assembly of the genome with unpaired reads in order to evaluate the repeat structure of the genome; then generate the mate-pair libraries that provide most information towards the resolution of repeats in the genome being assembled - is not only possible, but likely also more cost-effective as it will significantly reduce downstream manual finishing costs. In future work we intend to address the question of whether this result can be extended to larger eukaryotic genomes, where repeat structure can be quite different.
Plasmon-loss imaging of chains of crystalline-silicon nanospheres and silicon nanowires (2000)

Nanostructures in chains of crystalline-silicon nanospheres and silicon nanowires were investigated using energy-filtered transmission electron microscopy (TEM). Observation of the shape of the silicon nanospheres in the chains provided the direct evidence that the chains were formed via the surface oxidation process, which may preferentially work at the necks. The diverse nanostructures in silicon nanowires were revealed, and we found smooth-shaped wires which have periodically modulated silicon cores. Nanostructures in wire-chain transition regions were also investigated for the first time. The wire-chain transition is not a simple junction of a silicon nanowire and a chain of silicon nanospheres, but has a periodically modulated silicon core in the wire region near the transition position.
Big Is Beautiful−“Aromaticity” Revisited from the Viewpoint of Macromolecular and Supramolecular Benzene Chemistry (2001)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBig Is Beautiful−"Aromaticity" Revisited from the Viewpoint of Macromolecular and Supramolecular Benzene ChemistryMark D. Watson, Andreas Fechtenkötter, and Klaus MüllenView Author Information Max-Planck-Institut für Polymerforschung, Ackermannweg 10, D-55128 Mainz, Germany Cite this: Chem. Rev. 2001, 101, 5, 1267–1300Publication Date (Web):April 20, 2001Publication History Received22 September 2000Published online20 April 2001Published inissue 1 May 2001https://pubs.acs.org/doi/10.1021/cr990322phttps://doi.org/10.1021/cr990322presearch-articleACS PublicationsCopyright © 2001 American Chemical SocietyRequest reuse permissionsArticle Views12722Altmetric-Citations1264LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Aromatic compounds,Chemical structure,Hydrocarbons,Molecules,Polymers Get e-Alerts
Bacterial Adherence to Tantalum Versus Commonly Used Orthopedic Metallic Implant Materials (2006)

Because bacterial adhesion is an important predisposing factor in the development of clinical implant infection, tantalum may offer benefits as an adjunct or alternative material compared with current materials commonly used for orthopedic implants.
Enhancing robotic unstructured bin-picking performance by enabling remote human interventions in challenging perception scenarios (2016)

We present an approach that enables a robot to initiate a call to a remote human operator and ask help in resolving automated perception system failures during bin-picking operations. Our approach allows a robot to evaluate the quality of part recognition and pose estimation, based on a confidence-measure, and thereby determine whether to proceed with the task execution or to request assistance from a human in resolving the predicted perception failure. We present an automated perception algorithm that performs the joint task of part recognition and 6 degree-of-freedom pose estimation, and has built-in features to initiate the call to the human when needed. We also present the underlying mechanism for a rationalized basis for making the call to the human. If uncertainty in part detection leads to perception failure, then human intervention is invoked. We present a new user interface that enables remote human interventions when necessary. We report results from experiments with a dual-armed Baxter robot to validate our approach.
New <i>Orientia tsutsugamushi</i> Strain from Scrub Typhus in Australia (1998)

In a recent case of scrub typhus in Australia, Orientia tsutsugamushi isolated from the patient's blood was tested by sequence analysis of the 16S rDNA gene. The sequence showed a strain of O. tsutsugamushi that was quite different from the classic Karp, Kato, and Gilliam strains. The new strain has been designated Litchfield.
Compression of multichannel ECG through multichannel long-term prediction (1998)

The need for efficient coding of ECG signals is continually increasing with modern use of long-term monitoring and telemedicine. Here, the authors present an algorithm based on long-term prediction (LTP) compression. The single-channel LTP algorithm has been generalized to the multichannel case and is called the MC-LTP algorithm. This algorithm compresses PQRST beats using a pattern codebook with "typical" beats.
Reaction mechanism of fluorinated chemically amplified resists (2006)

The halogenation of resist materials is a well-known strategy for the improvement in resist performance particularly in electron beam and x-ray resists. However, for chemically amplified resists, the halogenation of polymers requires particular caution because halogenated polymers may interfere with acid generation. In this work, acid generation in poly[4-hydroxystyrene-co-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropyl)-styrene] films was investigated using steady-state spectroscopy and pulse radiolysis. Acid yield decreased with an increase in the ratio of hexafluoroalcohol units. It was found that the reactivity of polymers with low-energy electrons (∼thermal energy) correlates to the decrease in acid yield.
Toronto Transit Commission communications and information system evaluation of operationa tests (1980)

Components and pilot testing of the Toronto Transit Commission's (TTC) bus communications/monitoring/control system are described. Developed in conjunction with the Ontario Ministry of Transportation and Communications, the Communications and Information System (CIS) provides for emergency assistance, route supervision, schedule development, performance reporting, passenger information, and traffic signal prioritization. The CIS equipment used currently and in testing consists of a two-way voice and digital radio, mobile terminal, and vehicle location and passenger counting devices; two control consoles and associated displays and computers at the Wilson Division Control Centre; and a passenger information display at the Wilson Subway Station. Operational tests were conducted in Oct-Dec 1979 on the Wilson Division's 100 bus fleet operating on six TTC routes. Capabilities were measured using before-and-after surveys and interviews with controllers, inspectors, and operators. A 3% to 5% improvement in service efficiency was found and the system was considered cost/effective. The CIS is now being expanded to the TTC's total surface fleet of 1600 vehicles, including buses, trolleys, and streetcars.
Recombinant Human Thyrotropin (TSH) Receptor in a Radioreceptor Assay for the Measurement of TSH Receptor Autoantibodies* (1991)

We studied the suitability of using the recombinant human TSH receptor expressed in Chinese hamster ovary cells in a TSH binding inhibition (TBI) assay for autoantibodies against the TSH receptor. Purified immunoglobulin G (IgG) containing potent thyroid-stimulating immunoglobulin bioactivity competed for radiolabeled TSH binding to recombinant TSH receptor in parallel to inhibition by unlabeled TSH. Using polyethylene glycol-prepared IgG, this assay discriminated very well between sera from normal individuals [TBI, 0.98 +/- 0.04 (+/- SD); range, 0.92-1.08; n = 35] and patients with untreated Graves' disease (TBI, 0.49 +/- 0.23; range, 0.06-0.98; n = 93). Only four of the sera from the untreated Graves' patients were TBI negative (greater than or equal to 0.92), providing a sensitivity of 96%. In sera from patients with Graves' disease receiving antithyroid drug therapy, TBI was 0.63 +/- 0.18 (range, 0.19-0.97; n = 75). In this group of treated patients, 2 of 75 were TBI negative. Four of 12 patients with Hashimoto's thyroiditis (33%) were positive for TBI activity. All 18 patients with nonautoimmune thyroid diseases (toxic nodular goiter, single toxic adenoma, subacute thyroiditis, or thyroid cancer) were TBI negative. Correlation of the TBI values with thyroid-stimulating immunoglobulin bioactivity revealed a generally positive correlation (r = 0.31; P less than 0.05); however, there were many discrepancies among individual sera. TSI bioactivity was undetectable in all 4 patients with Hashimoto's thyroiditis who were TBI positive. These data indicate that the recombinant TSH receptor in Chinese hamster ovary cells is a suitable system for detecting TBI activity in the sera of patients with autoimmune thyroid disease.
Modal Cina Dan Nasionalisme Indonesia: Industri Pers Cina Pada Masa Pergerakan Nasional, 1910-1942 (1999)

The delayed rectifier voltage-gated potassium channel Kv2.1 underlies a majority of the somatic K(+) current in neurons and is particularly important for regulating intrinsic neuronal excitability. Various stimuli alter Kv2.1 channel gating as well as localization of the channel to cell-surface cluster domains. It has been postulated that specific domains within the C-terminus of Kv2.1 are critical for channel gating and sub-cellular localization; however, the distinct regions that govern these processes remain elusive. Here we show that the soluble C-terminal fragment of the closely related channel Kv2.2 displaces Kv2.1 from clusters in both rat hippocampal neurons and HEK293 cells, however neither steady-state activity nor N-methyl-d-aspartate (NMDA)-dependent modulation is altered in spite of this non-clustered localization. Further, we demonstrate that the C-terminus of Kv2.1 is not necessary for steady-state gating, sensitivity to intracellular phosphatase or NMDA-dependent modulation, though this region is required for localization of Kv2.1 to clusters. Thus, the molecular determinants of Kv2.1 localization and modulation are distinct regions of the channel that function independently.
Multiwavelength tunable liquid-crystal etalon filter (1991)

Using a liquid-crystal Fabry-Perot etalon with multielement electrodes, the authors demonstrated a tunable filter capable of simultaneously filtering many wavelengths in the 1.2-1.6 mu m wavelength region. The configuration is demonstrated by tuning two wavelengths independently by applying different voltages to two electrodes. Each of the passbands could be tuned over the free spectral range (65 nm) with an applied voltage of 1 to 3 V.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
New approach to optical analysis of absorbing thin solid films (1987)

A powerful new technique is reported which enables realistic calculation of the optical energy gap of absorbing thin solid films by an analysis of measured transmittance and reflectance spectra in the fundamental absorption region. At the same time a new analytical method allows the thickness of films to be evaluated by measurements of transmittance only.
Effectiveness of complete versus partial androgen withdrawal therapy for the treatment of prostatic cancer as studied in the Dunning R-3327 system of rat prostatic adenocarcinomas. (1985)

Standard initial therapy for metastatic prostatic cancer involves surgical or chemically induced castration. Castration lowers the serum testosterone level by over 90% but does not completely eliminate all potential serum androgens (i.e., it induces a partial androgen withdrawal). This has led some investigators to suggest that a more complete form of androgen withdrawal in which the very low levels of serum androgens remaining after castration are neutralized by the simultaneous treatment with a direct acting antiandrogen (i.e., complete androgen withdrawal) might be more effective than simply castration alone. To determine whether complete androgen withdrawal is any more effective than partial androgen withdrawal therapy, the slow growing, well differentiated H and the fast growing, poorly differentiated G sublines of the serially transplantable Dunning R-3327 system of rat prostatic adenocarcinomas were used as a test system since both of these cancers are androgen responsive. These studies demonstrated that: (a) complete androgen withdrawal consisting of surgical castration in combination with daily treatment with the potent antiandrogen, cyproterone acetate, was no more effective in terms of tumor growth retardation or overall host survival than was partial androgen withdrawal induced by castration alone; (b) serum testosterone levels must be maintained below 0.5 ng/ml but do not have to be completely eliminated to produce the maximum therapeutic response; and (c) prostatic cancers are more sensitive than is the normal prostate to growth stimulation by serum testosterone.
The Synthesis of the 3,9-Diazabicyclo [3.3.1] nonane Ring System<sup>1</sup> (1953)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Synthesis of the 3,9-Diazabicyclo [3.3.1] nonane Ring System1Roderick A. Barnes and Henry M. FalesCite this: J. Am. Chem. Soc. 1953, 75, 4, 975–977Publication Date (Print):February 1, 1953Publication History Published online1 May 2002Published inissue 1 February 1953https://pubs.acs.org/doi/10.1021/ja01100a060https://doi.org/10.1021/ja01100a060research-articleACS PublicationsRequest reuse permissionsArticle Views140Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The fabrication and characterization of adjustable nanogaps between gold electrodes on chip for electrical measurement of single molecules (2010)

This work reports on a new method to fabricate mechanically controllable break junctions (MCBJ) with finely adjustable nanogaps between two gold electrodes on solid state chips for characterizing electron transport properties of single molecules. The simple, low cost, robust and reproducible fabrication method combines conventional photolithography, chemical etching and electrodeposition to produce suspended electrodes separated with nanogaps. The MCBJ devices fabricated by the method can undergo many cycles in which the nanogap width can be precisely and repeatedly varied from zero to several nanometers. The method improves the success rate of the MCBJ experiments. Using these devices the electron transport properties of a typical molecular system, commercially available benzene-1,4-dithiol (BDT), have been studied. The I-V and G-V characteristic curves of BDT and the conductance value for a single BDT molecule established the excellent device suitability for molecular electronics research.
Analysis of Anaphora Resolution System for English Language (2014)

Anaphora resolution is complex problem in linguistics and has attracted the attention of many researchers. It is the problem of identifying referents in the discourse. Anaphora Resolution plays an important role in Natural language processing task. This paper completely emphasis on pronominal anaphora resolution for English Language in which pronouns refers to the intended noun in discourse. In this paper two computational models are proposed for anaphora resolution. Resolution of anaphora is based on various factors among which these models use Recency factor and Animistic Knowledge. Recency factor is implemented by using Lappin Leass approach in first model and using Centering approach in second model. Information about animacy is obtained by Gazetteer method. The identification of animistic elements is employed to improve the accuracy of the system. This paper demonstrates experiment conducted by both the models on different data sets from different domains. A comparative result of both the model is summarized and conclusion is drawn for the best suitable model.
The Role of the DAP12 Signal in Mouse Myeloid Differentiation (2000)

DAP12 is a recently cloned, immunoreceptor tyrosine-based activation motif-bearing transmembrane adapter molecule that is associated with the NK-activating receptors. Previous reports showed that the DAP12 message could be detected not only in NK cells but also in granulocytes, monocytes, dendritic cells, and macrophages. In this study we found a significant level of DAP12 protein expression in macrophage-related cell lines and organs. Additionally, we observed increased expression of DAP12 after LPS-induced differentiation of M1 cells into macrophages. To examine the role of DAP12 in the myeloid cell lineage, we established M1 FLAG-DAP12 transfectants (FDAP-M1) and demonstrated the marked morphological changes in FDAP-M1 cells caused by signaling through DAP12. Cell surface phenotypic analysis showed up-regulation of macrophage markers CD11b, 2.4G2, and adhesion molecule B7-2. Additionally, after stimulation through DAP12, phosphorylated FLAG -DAP12 could be immunoprecipitated using anti-phosphotyrosine mAbs. Collectively, these findings indicate that direct DAP12 signaling has an important role in macrophage differentiation.
Comparison of Dual Focus Collector Schemes for Fiber Systems (1997)

<div class="htmlview paragraph">The development of efficient, multi-output High Intensity Discharge (HID) light sources is important for driving fiber systems in automotive applications, in particular for headlamps. Such systems must collect a large fraction of the light from the HID source while efficiently coupling the light into large core light pipes.</div> <div class="htmlview paragraph">An earlier paper [<span class="xref">1</span>] showed how multifocus optical systems can efficiently split the light evenly between separate output ports. Multifocus systems were shown to be more efficient than a mixing rod approach, especially for the case of two ports. In the case of dual output systems, many more cases need to be considered. To facilitate the investigation, a state-of-the-art optical analysis/design program was employed to demonstrate the tradeoffs between six different dual focus geometries. A novel dual ellipse approach is presented.</div>
Autonomous decentralized voltage profile control of super‐distributed energy system using multi‐agent technology (2008)

Abstract A super‐distributed energy system is a future energy system in which a large part of its demand is fed by a huge number of distributed generators. At one time some nodes in the super‐distributed energy system behave as load, whereas at other times they behave as generator—the characteristic of each node depends on the customers' decision. In such situation, it is very difficult to regulate the voltage profile over the system due to the complexity of power flows. This paper proposes a novel control method of distributed generators that can achieve autonomous decentralized voltage profile regulation by using multi‐agent technology. The proposed multi‐agent system employs two types of agent: a control agent and a mobile agent. Control agents generate or consume reactive power to regulate the voltage profile of neighboring nodes and mobile agents transmit the information necessary for VQ‐control among the control agents. The proposed control method is tested through numerical simulations. © 2008 Wiley Periodicals, Inc. Electr Eng Jpn, 164(4): 43–52, 2008; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/eej.20484
A context-sensitive security model for privacy protection on mobile phones (2009)

In this paper we present a context-sensitive security model for privacy protection on mobile phones. We describe the system TreasurePhone which implements this security model. The Privacy Protection is realized by spheres, which represent the user's context specific need for privacy. That is, users can create any number of spheres and define which services and data are accessible in each sphere. TreasurePhone integrates context information for supporting authentication and activation of spheres by locations and actions. A basic hierarchy is used for determining which location should be activated based on the associated sensor value.
"Scalable Modeling Studies on the SCR ESD Protection Device" (2011)

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