gebhart/patrepeval huggingface dataset:
The NADPH Oxidase Inhibitor Imipramine-Blue in the Treatment of Burkitt Lymphoma (2014)

Burkitt lymphoma is a rare malignancy arising from B cells. Current chemotherapeutic regimens achieve excellent overall survival rates in children, but less impressive rates in adults. There are cases with poor outcome caused by toxic effects of the therapy, tumor lysis syndrome, or metastatic spread of lymphomas to the central nervous system. Modulators of reactive oxygen species are currently discussed as potential drugs for the treatment of cancer. The NADPH oxidase 4 inhibitor imipramine-blue might satisfy the aforementioned requirements, and was studied here. We used MTT assay, crystal violet assay, and thymidine 3H-incorporation assay to analyze the effects of imipramine-blue on Burkitt lymphoma (BL2, BL2B95, BL30B95, BL41B95), neuroblastoma (KELLY, SH-SY5Y, SMS-KAN), cervix carcinoma (HeLa), breast cancer (MDA-MB231), angiosarcoma (AS-M), human embryonic kidney (HEK293WT), and nonmalignant (FLP1) cell lines. The effects of imipramine-blue on BL2B95 cells in vivo were investigated in xenografts on the chick chorioallantoic membrane (CAM). We report that imipramine-blue is a potent growth inhibitor for several cancer cell lines in vitro with IC(50) values comparable to those of doxorubicin (0.16-7.7 μmol/L). Tumor size of BL2B95 cells inoculated in the CAM was reduced significantly (P < 0.05) after treatment with 10 μmol/L imipramine-blue. Lymphogenic dissemination of BL2B95 and the formation of blood and lymphatic vessels in experimental tumors were not affected. We show that imipramine-blue can be used to decrease the viability of cancer cell lines in vitro and in vivo. Imipramine-blue reduces the size of experimental Burkitt lymphoma significantly but does not affect the dissemination of BL2B95 cells, angiogenesis, and lymphangiogenesis.
Entre science et littérature (1991)

Between literature and science. The two realms of literature and science have variously provoked attempts to distinguish and differentiate them. This essay argues that both should be studied as related modes of producing meaning. Rather than using the history of science as auxiliary science for the better interpreting of the literary text, it suggests that figures of thought, that are often characteristic of single sciences, offer a privileged object for the study of the inter-relationship of both realms.
Acylhydrazones as Widely Tunable Photoswitches (2015)

Molecular photoswitches have attracted much attention in biological and materials contexts. Despite the fact that existing classes of these highly interesting functional molecules have been heavily investigated and optimized, distinct obstacles and inherent limitations remain. Considerable synthetic efforts and complex structure-property relationships render the development and exploitation of new photoswitch families difficult. Here, we focus our attention on acylhydrazones: a novel, yet underexploited class of photochromic molecules based on the imine structural motif. We optimized the synthesis of these potent photoswitches and prepared a library of over 40 compounds, bearing different substituents in all four crucial positions of the backbone fragment, and conducted a systematic study of their photochromic properties as a function of structural variation. This modular family of organic photoswitches offers a unique combination of properties and the compounds are easily prepared on large scales within hours, through an atom-economic synthesis, from commercially available starting materials. During our thorough spectroscopic investigations, we identified photoswitches covering a wide range of thermal half-lives of their (Z)-isomers, from short-lived T-type to thermally stable P-type derivatives. By proper substitution, excellent band separation between the absorbance maxima of (E)- and (Z)-isomers in the UV or visible region could be achieved. Our library furthermore includes notable examples of rare negative photochromic systems, and we show that acylhydrazones are highly fatigue resistant and exhibit good quantum yields.
Scanning x-ray microscope with 75-nm resolution (1988)

A scanning soft x-ray microscope has been built and operated at the National Synchrotron Light Source. It makes use of a mini-undulator as a bright source of 3.2-nm photons. An electron beam fabricated Fresnel zone plate focuses the beam onto the specimen, which is scanned under computer control. The scanning stage can be moved by both piezoelectric transducers and stepping motors, and the location is monitored by a high-speed laser interferometer. X rays transmitted through the specimen are detected using a flow proportional counter. Images of biological specimens and of artificial microstructures have been made with resolution in the 75–100-nm range. Acquisition time for 256×256-pixel images is about 5 min.
Fibrillar amyloid-β burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease (2009)

Fibrillar amyloid-beta (Abeta) is found in the brains of many cognitively normal older people. Whether or not this reflects a predisposition to Alzheimer's disease (AD) is unknown. We used Pittsburgh Compound B (PiB) PET to characterize the relationship between fibrillar Abeta burden and this predisposition in cognitively normal older people at 3 mean levels of genetic risk for AD. Dynamic PiB PET scans, the Logan method, statistical parametric mapping, and automatically labeled regions of interest (ROIs) were used to characterize and compare cerebral-to-cerebellar PIB distribution volume ratios, reflecting fibrillar Abeta burden, in 28 cognitively normal persons (mean age, 64 years) with a reported family history of AD and 2 copies, 1 copy, and no copies of the apolipoprotein E (APOE) epsilon4 allele. The 8 epsilon4 homozygotes, 8 heterozygotes, and 12 noncarriers did not differ significantly in terms of age, sex, or cognitive scores. Fibrillar Abeta was significantly associated with APOE epsilon4 carrier status and epsilon4 gene dose in AD-affected mean cortical, frontal, temporal, posterior cingulate-precuneus, parietal, and basal ganglia ROIs, and was highest in an additional homozygote who had recently developed mild cognitive impairment. These findings suggest that fibrillar Abeta burden in cognitively normal older people is associated with APOE epsilon4 gene dose, the major genetic risk factor for AD. Additional studies are needed to track fibrillar Abeta accumulation in persons with different kinds and levels of AD risk; to determine the extent to which fibrillar Abeta, alone or in combination with other biomarkers and risk factors, predicts rates of cognitive decline and conversion to clinical AD; and to establish the role of fibrillar Abeta imaging in primary prevention trials.
Mechanisms of Resistance to Quinolones (2005)

The increased use of fluoroquinolones has led to increasing resistance to these antimicrobials, with rates of resistance that vary by both organism and geographic region. Resistance to fluoroquinolones typically arises as a result of alterations in the target enzymes (DNA gyrase and topoisomerase IV) and of changes in drug entry and efflux. Mutations are selected first in the more susceptible target: DNA gyrase, in gram-negative bacteria, or topoisomerase IV, in gram-positive bacteria. Additional mutations in the next most susceptible target, as well as in genes controlling drug accumulation, augment resistance further, so that the most-resistant isolates have mutations in several genes. Resistance to quinolones can also be mediated by plasmids that produce the Qnr protein, which protects the quinolone targets from inhibition. Qnr plasmids have been found in the United States, Europe, and East Asia. Although Qnr by itself produces only low-level resistance, its presence facilitates the selection of higher-level resistance mutations, thus contributing to the alarming increase in resistance to quinolones.
Chattering reduction using multiphase sliding mode control (2009)

For the system with sliding mode controllers operated by on/off switches, 'chattering' appears in the output of the system when its switching frequency is restricted. In power systems, the switching frequency is commonly limited to prevent power losses, and chattering or 'ripple' appears especially in the system current. Common methods to decrease such ripple are based on 'harmonic cancellation' using the multiple number of phase channels having the desired phase shift that brings cancellation in the sum of outputs from the individual channels. In this article, a design principle of sliding mode control for a multiphase controller is proposed. The methodology is originated from the concept of multidimensional sliding mode and provides desired phase shifts between phases with the help of adaptive width for the hysteresis loops in switching elements. The chattering suppression effect is demonstrated by simulations for the DC–DC converter systems in various situations.
On the Influence of Mainstream Poetics upon Translation——Taking Wang Keyi's Chinese Translation of Pride and Prejudice as an example (2013)

Translation is not only the communication but also the merging between two different cultures.In order to reproduce the effects of original versions in the target language context,translation processes are inevitably influenced by the target culture.Based on Lefevere's concept of poetics in his manipulation theory and taking Wang Keyi's version of Pride and Prejudice as a case,this paper attempts to discuss poetics in Wang Keyi's time,analyze his version from the perspectives of diction and syntactical structure which are two representation forms of poetics,and illustrate that influenced by mainstream poetics the translators are going to rewrite and manipulate original texts,making translated texts conform to poetics ideas,to ensure successful a translation process under the times' culture context.
Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response. (2012)

The Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades are often activated by genetic alterations in upstream signaling molecules such as receptor tyrosine kinases (RTK). Certain components of these pathways, RAS, NF1, BRAF, MEK1, DUSP5, PP2A, PIK3CA, PIK3R1, PIK3R4, PIK3R5, IRS4, AKT, NFKB1, MTOR, PTEN, TSC1, and TSC2 may also be activated/inactivated by mutations or epigenetic silencing. Upstream mutations in one signaling pathway or even in downstream components of the same pathway can alter the sensitivity of the cells to certain small molecule inhibitors. These pathways have profound effects on proliferative, apoptotic and differentiation pathways. Dysregulation of components of these cascades can contribute to: resistance to other pathway inhibitors, chemotherapeutic drug resistance, premature aging as well as other diseases. This review will first describe these pathways and discuss how genetic mutations and epigenetic alterations can result in resistance to various inhibitors.
Amine-Functionalized MIL-53 Metal–Organic Framework in Polyimide Mixed Matrix Membranes for CO<sub>2</sub>/CH<sub>4</sub> Separation (2012)

Flexible crystalline metal–organic framework (MOF) of nanosize particles (Al-MIL-53) and 6FDA-ODA polyimides were used to produce mixed matrix membranes (MMM). These MMM display excellent CO2/CH4 separation properties even without any compatibilization (amine grafting). The ideal selectivity and separation factor were found to increase with increasing MOF loading. Furthermore, these materials have an improved CO2/CH4 separation factor with increasing pressure, in contrast to traditional polymer membranes.
Optical 90° hybrid with broad operating bandwidth of 94 nm (2009)

We propose an optical 90 degree hybrid where no waveguide intersection in coupling to balanced photodiodes is required for coherent detection. The proposed device consisting of a paired-interference 2x4 multimode interference (MMI) coupler, a phase shifter, and a 2x2 MMI coupler exhibited quadrature phase response over a 94-nm-wide spectral range.
Results of a Phase I dose-escalating study of the antiangiogenic agent, SU5416, in patients with advanced malignancies. (2002)

SU5416 is a small molecule antiangiogenic agent that inhibits vascular endothelial growth factor (VEGF) stimulation of the KDR tyrosine kinase receptor. In this Phase I dose escalation trial, a weekly dose schedule of SU5416 was tested whereby an initial 5-day loading dose was followed by weekly maintenance infusions. The start dose was 20 mg/m(2) for the loading dose followed by 65 mg/m(2) for the weekly infusions. Dose escalations occurred at 33% until a final dose of 65 mg/m(2) (loading dose) and 190 mg/m(2) (weekly infusion) was obtained. Twenty-two patients were treated at five dose levels; tumor types included gastrointestinal (8), breast (3), lung (4), sarcoma (2), and other (5). The most common serious drug-related toxicity was headache, often associated with nausea and vomiting. Grade 1 and 2 toxicities included headache, nausea, vomiting, asthenia, pain at the infusion site, phlebitis, change in voice, and fevers. Of 19 evaluable patients, 4 obtained clinical benefit as defined by tumor regression (1) or disease stabilization for at least 12 weeks (3). Pharmacokinetic data revealed that the weekly infusion schedule prevented the reported 50-60% induction in SU5416 clearance observed with either daily or twice weekly dosing. Higher baseline levels of urine VEGF were observed in the 4 patients who gained clinical benefit, suggesting this may be a useful marker for predicting response to anti-VEGF therapies. Our results suggest that a weekly schedule of SU5416 shows signs of biological activity and is well tolerated at doses up to 145 mg/m(2).
Heparan Sulfate Is a Cellular Receptor for Purified Infectious Prions (2005)

Prions replicate in the host cell by the self-propagating refolding of the normal cell surface protein, PrP(C), into a beta-sheet-rich conformer, PrP(Sc). Exposure of cells to prion-infected material and subsequent endocytosis can sometimes result in the establishment of an infected culture. However, the relevant cell surface receptors have remained unknown. We have previously shown that cellular heparan sulfates (HS) are involved in the ongoing formation of scrapie prion protein (PrP(Sc)) in chronically infected cells. Here we studied the initial steps in the internalization of prions and in the infection of cells. Purified prion "rods" are arguably the purest prion preparation available. The only proteinaceous component of rods is PrP(Sc). Mouse neuroblastoma N2a, hypothalamus GT1-1, and Chinese hamster ovary cells efficiently bound both hamster and mouse prion rods (at 4 degrees C) and internalized them (at 37 degrees C). Treating cells with bacterial heparinase III or chlorate (a general inhibitor of sulfation) strongly reduced both binding and uptake of rods, whereas chondroitinase ABC was inactive. These results suggested that the cell surface receptor of prion rods involves sulfated HS chains. Sulfated glycans inhibited both binding and uptake of rods, probably by competing with the binding of rods to cellular HS. Treatments that prevented endocytosis of rods also prevented the de novo infection of GT1-1 cells when applied during their initial exposure to prions. These results indicate that HS are an essential part of the cellular receptor used both for prion uptake and for cell infection. Cellular HS thus play a dual role in prion propagation, both as a cofactor for PrP(Sc) synthesis and as a receptor for productive prion uptake.
Current status of research on sperm antigens: potential applications as contraceptive vaccines. (1983)

Immunocontraception has been suggested as a solution to the need for alternative and reversible contraception. This article reviews the current status of research on sperm antigens and discusses their potential role in the development of a new contraceptive technology. A contraceptive vaccine is suggested by the observed association between infertility and antisperm antibodies in both male and female human subjects. Fertility suppression has been well documented in female laboratory animals immunized with sperm. The goal of current research efforts is to identify the responsible antigen(s) from extracts of sperm and testes. Development of a contraceptive vaccine requires a highly specific and immunogenic sperm antigen that is available in relatively large quantities and is amenable to chemical synthesis. Lactate dehydrogenase C4 (LDH-C4; LDH-X) appears to be the most viable sperm-specific antigen for vaccine development. Immunization with LDH-C4 does suppress fertility, and the complete biochemical characterization of this isoenzyme is underway. Research suggests that LDH-C4 immunization results in immunoglobulins that enter the female reproductive tract and prevent sperm from fertilizing the egg. Manipulation of the secretory immune system of the female reproductive tract could enhance the immunocontraceptive effect. For LDH-C4 to provide the basis for a practical immunological contraceptive, 2 major problems must be overcome: 1) a synthetic substitute for the natural product antigen must be identified, and 2) the contraceptive effect must be made more nearly complete. Despite these practical problems, prospects are good that a vaccine to prevent pregnancy will become available during the next decade.
EFEMP1 suppresses malignant glioma growth and exerts its action within the tumor extracellular compartment (2011)

Overall, our data reveals that EEFEMP1 suppresses glioma growth in vivo, both by modulating the tumor extracellular microenvironment and by altering critical intracellular oncogenic signaling pathways.
Treatment of axial data in three-dimensional PET. (1987)

Improved axial spatial resolution in positron emission tomography (PET) scanners will lead to reduced sensitivity unless the axial acceptance angle for the coincidences is kept constant. A large acceptance angle, however, violates assumptions made in most reconstruction algorithms, which reconstruct parallel independent slices, rather than a three-dimensional volume. Two methods of treating the axial information from a volume PET scanner are presented. Qualitative and quantitative errors introduced by the approximations are examined for simulated objects with sharp boundaries and for a more anatomically realistic distribution with smooth activity gradients.
An indoor human motion detection algorithm based on channel state information (2017)

Human motion detection based on CSI (Channel State Information) is a hot research topic. Many researchers started to focus on it. By extracting amplitude and phase of CSI, it can be applied to detect human motions. In this paper, we employ the phase to detect intrusion. Firstly, we use a liner transformation to eliminate the shift of phases of different subcarriers. Subsequently, we defined two reference points for the short-term case(SES) and the long-term case(LES). The former is used to detect if someone is walking in indoor room and the latter is to detect whether the person is walking continuously. We implemented our approaches with the normal WiFi equipment and evaluated the performances of our algorithm in real environment. Experimental results show a high accuracy of our algorithm.
Combinatorial Ligand-directed Lung Targeting (2009)

Phage display of random peptide libraries is a powerful, unbiased method frequently used to discover ligands for virtually any protein of interest and to reveal functional protein-protein interaction partners. Moreover, in vivo phage display permits selection of peptides that bind specifically to different vascular beds without any previous knowledge pertaining to the nature of their corresponding receptors. Vascular targeting exploits molecular differences inherent in blood vessels within given organs and tissues, as well as diversity between normal and angiogenic blood vessels. Over the years, our group has identified phage capable of homing to lung blood vessels based on screenings using immortalized lung endothelial cells combined with in vivo selections after intravenous administration of combinatorial libraries. Peptides targeting lung vasculature have been extensively characterized and a lead homing peptide has shown interesting biological properties, bringing novel insights as to the implications of lung endothelial cell apoptosis in the pathogenesis of emphysema. We have also designed and developed targeted nanoparticles with imaging capabilities and/or drug delivery functions by combining phage display technology and elemental gold (Au) nanoparticles, constituting a promising platform for the development of therapeutic agents for imaging and treatment of lung disorders. Given the important role of the endothelium in the pathogenesis and progression of several diseases associated with the airways, ligand-directed discovery of lung vascular markers is an important milestone toward the development of future targeted therapies.
Neuromuscular Treatments for Speech and Swallowing (2003)

Despite the proliferation of oral motor therapies, much controversy exists regarding the application and benefit of neuromuscular treatments (NMTs) such as strength training for alleviating dysarthria and/or dysphagia. Not only is limited empirical support available to validate the use of NMTs, but clinicians may also lack the foundational information needed to judge the theoretical soundness of unstudied treatment strategies. This tutorial reviews the theoretical foundations for several NMTs, including active exercises, passive exercises, and physical modalities. It highlights how these techniques have been used to address neuromuscular impairments in the limb musculature and explores potential applications to the speech and swallowing musculature. Key issues discussed in relation to active exercise are the selection of treatment targets (e.g., strength, endurance, power, range of motion), specificity of training, progression, and recovery. Factors influencing the potential effectiveness of passive exercises and physical modalities are presented, along with discussion of additional issues contributing to the controversy surrounding oral motor therapies.
ABCD1 mutations and the X-linked adrenoleukodystrophy mutation database: Role in diagnosis and clinical correlations (2001)

X-linked adrenoleukodystrophy (X-ALD) is caused by mutations in the ABCD1 gene, which encodes a peroxisomal ABC half-transporter (ALDP) involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome. The disease is characterized by a striking and unpredictable variation in phenotypic expression. Phenotypes include the rapidly progressive childhood cerebral form (CCALD), the milder adult form, adrenomyeloneuropathy (AMN), and variants without neurologic involvement. There is no apparent correlation between genotype and phenotype. In males, unambiguous diagnosis can be achieved by demonstration of elevated levels of VLCFA in plasma. In 15 to 20% of obligate heterozygotes, however, test results are false-negative. Therefore, mutation analysis is the only reliable method for the identification of heterozygotes. Since most X-ALD kindreds have a unique mutation, a great number of mutations have been identified in the ABCD1 gene in the last seven years. In order to catalog and facilitate the analysis of these mutations, we have established a mutation database for X-ALD ( http://www.x-ald.nl). In this review we report a detailed analysis of all 406 X-ALD mutations currently included in the database. Also, we present 47 novel mutations. In addition, we review the various X-ALD phenotypes, the different diagnostic tools, and the need for extended family screening for the identification of new patients.