gebhart/patrepeval huggingface dataset:
cAMP Response Element-Binding Protein Is a Primary Hub of Activity-Driven Neuronal Gene Expression (2011)

Long-lasting forms of neuronal plasticity require de novo gene expression, but relatively little is known about the events that occur genome-wide in response to activity in a neuronal network. Here, we unveil the gene expression programs initiated in mouse hippocampal neurons in response to different stimuli and explore the contribution of four prominent plasticity-related transcription factors (CREB, SRF, EGR1, and FOS) to these programs. Our study provides a comprehensive view of the intricate genetic networks and interactions elicited by neuronal stimulation identifying hundreds of novel downstream targets, including novel stimulus-associated miRNAs and candidate genes that may be differentially regulated at the exon/promoter level. Our analyses indicate that these four transcription factors impinge on similar biological processes through primarily non-overlapping gene-expression programs. Meta-analysis of the datasets generated in our study and comparison with publicly available transcriptomics data revealed the individual and collective contribution of these transcription factors to different activity-driven genetic programs. In addition, both gain- and loss-of-function experiments support a pivotal role for CREB in membrane-to-nucleus signal transduction in neurons. Our data provide a novel resource for researchers wanting to explore the genetic pathways associated with activity-regulated neuronal functions.
Crystal Structures of the Family 9 Carbohydrate-Binding Module from <i>Thermotoga maritima</i> Xylanase 10A in Native and Ligand-Bound Forms<sup>,</sup> (2001)

The C-terminal module of the thermostable Thermotoga maritima xylanase 10A (CBM9-2) is a family 9 carbohydrate-binding module that binds to amorphous and crystalline cellulose and a range of soluble di- and monosaccharides as well as to cello and xylo oligomers of different degrees of polymerization [Boraston, A. B., Creagh, A. L., Alam, Md. M., Kormos, J. M., Tomme, P., Haynes, C. A., Warren, R. A. J., and Kilburn, D. G. (2001) Biochemistry 40, 6240-6247]. The crystal structure of CBM9-2 has been determined by the multiwavelength anomalous dispersion method to 1.9 A resolution. CBM9-2 assumes a beta-sandwich fold and contains three metal binding sites. The bound metal atoms, which are most likely calcium cations, are in an octahedral coordination. The crystal structures of CBM9-2 in complex with glucose and cellobiose were also determined in order to identify the sugar-binding site and provide insight into the structural basis for sugar binding by CBM9-2. The sugar-binding site is a solvent-exposed slot sufficient in depth, width, and length to accommodate a disaccharide. Two tryptophan residues are stacked together on the surface of the protein forming the sugar-binding site. From the complex structures with glucose and cellobiose, it was inferred that CBM9-2 binds exclusively to the reducing end of mono-, di-, and oligosaccharides with an intricate hydrogen-bonding network involving mainly charged residues, as well as stacking interactions by Trp175 and Trp71. The binding interactions are limited to disaccharides as was expected from calorimetric data. Comparison of the glucose and cellobiose complexes revealed surprising differences in binding of these two substrates by CBM9-2. Cellobiose was found to bind in a distinct orientation from glucose, while still maintaining optimal stacking and electrostatic interactions with the reducing end sugar.
T-lymphocyte subsets in smoking and lung cancer: Analysis of monoclonal antibodies and flow cytometry. (1982)

In order to determine whether abnormalities of immunoregulatory T-cells occur in patients with lung cancer, we characterized peripheral T-lymphocytes in 26 patients with untreated lung cancer. The results in patients with primary squamous cancer (SC) (n = 10), primary adenocarcinoma (AC) (n = 7), and secondary lung metastases (M) (n = 9) were compared with each other and to subjects without cancer (n = 48), including nonsmokers (n = 29) and smokers (n = 19). We found that OKT3+ (mature, peripheral (T-lymphocytes, including both OkT4+ (inducer/helper) and OKT8+ (cytotoxic/suppressor) lymphocytes, were increased in light-to-moderate smokers, but that OKT4+ cells were decreased n heavy smokers (p less than 0.05). The ratio of OKT4+ to OKT8+ (4/8) lymphocytes, reflecting the balance of immunoregulatory cells, was normal in light-to-moderate smokers, but was decreased in heavy smokers (p less than 0.05). The profile of circulating T-cells in patients with SC was similar to the smokers. In contrast, in patients with AC, we found a decreased percentage of OKT8+ cells (p less than 0.05). The 4/8 ratio was elevated in patients with AC (p less than 0.05). In patients with M, there was a decreased percentage of OKT3+ cells reflected in both OKT4+ and OKT8+ subsets. The 4/8 ratio in patients with M was low. Thus, a number of abnormalities in circulating T-cells was found both in smokers and in patients with lung cancer. These results suggest that immunoregulatory abnormalities contribute to the pathogenesis of lung cancer.
Transversely loaded Bragg grating pressure transducer with mechanically enhancing the sensitivity (2003)

In this paper, we describe a transversely loaded Bragg grating pressure transducer with mechanically enhanced the sensitivity utilizing fiber Bragg gratings written onto a single mode fiber, and demonstrate pressure sensitivity up to 5k psi with low temperature sensitivity.
Basic Characteristics of Humidity Controller with Membranes for Switch Box (1999)

This paper presents the characteristics of a basic experimental model of a newly developed dehumidifier with membrane as a humidity controller to guard against high levels of moisture concentration from the outside air. The model is an active steam discharger which removes moisture from inside the box utilizing temperature variations. It also prevents the intrusion of water vapor from the outside through the use of membranes and buffer spaces. The humidity controller consists of two cylindrical chambers and three membranes made of a waterproof film that separate the chambers and allows moisture to pass freely through without a water drain tube. Experimental results have shown that the basic design of the device can be employed in practical use to dehumidify air and eliminate permeation of moisture. It is not possible to keep an appropriate moisture level using a passive device without an electric power supply. However, by using the humidity controller, we can keep the relative humidity inside the electric device housing within a low level of risk of rusting.
Status of small reactor designs without on-site refuelling (2007)

The objective of this report is to provide Member States, including those considering the initiation of nuclear power programmes and those already having practical experience in nuclear power, with balanced and objective information on a number of issues. These include: important development trends and objectives of small reactors without on-site refuelling; achieving state of the art in design and technology development for such reactors; and their design status and possible applications. The report is intended for many categories of stakeholders, including electricity producers, policy makers, designers and regulators. The main chapters of this report survey emerging energy market characteristics, introduce a rationale for such reactors and review their design and technological development status with a consideration for associated fuel cycle and institutional issues. The annexes provide detailed design descriptions of small reactors without on-site refuelling, focusing on their potential to provide solutions in the areas of concern associated with future nuclear energy systems.
Integrated 3D-stacked server designs for increasing physical density of key-value stores (2014)

Key-value stores, such as Memcached, have been used to scale web services since the beginning of the Web 2.0 era. Data center real estate is expensive, and several industry experts we have spoken to have suggested that a significant portion of their data center space is devoted to key value stores. Despite its wide-spread use, there is little in the way of hardware specialization for increasing the efficiency and density of Memcached; it is currently deployed on commodity servers that contain high-end CPUs designed to extract as much instruction-level parallelism as possible. Out-of-order CPUs, however have been shown to be inefficient when running Memcached.
Multi-Modal Reflection Removal Using Convolutional Neural Networks (2019)

Although color images are easily interfered by glass, depth images captured by infrared sensors are robust to reflection. In this letter, we propose multi-modal reflection removal using convolutional neural networks (CNNs). We build a multi-modal CNN for reflection removal to separate transmission from reflection using depth information. The proposed network consists of two sub-networks: image restoration and depth adaptation. Image restoration sub-network (IRN) recovers transmission layer from the input image with reflection, whereas depth adaptation sub-network (DAN) guides reflection removal of the IRN. Moreover, to extract image details for reflection removal, we present a multi-scale loss function that penalizes non-similarity for multi-scale outputs. Experimental results demonstrate that the proposed method is robust to dominant reflections and outperforms state-of-the-art methods in terms of both peak signal-to-noise ratio (PSNR) and structural similarity.
Improving initialization through reversed retiming (1995)

Despite the fact that retiming circuits have a large potential (especially in automatically synthesized circuits from higher-level descriptions) it has not been widely included in the current design methodologies. One of the main problems is finding an equivalent initial state for the retimed logic. In this paper we introduce a new reverse retiming algorithm which will find a retiming for a given cycle time, if one exists. This new algorithm minimizes the effort required to find equivalent initial states and reduces the chance that the network needs to be modified to find an equivalent initial state. This algorithm is the kernel of a new efficient retiming method, which searches for optimal retimings preserving the initial state condition. >
RF-Input Load Modulated Balanced Amplifier With Octave Bandwidth (2017)

This paper presents an octave-bandwidth load modulated balanced amplifier (LMBA) that operates directly on a single modulated RF input. The architecture is based on the recently proposed LMBA technique, in which a control signal applied at the output isolation port of a balanced amplifier is used to modulate the apparent load impedance of the two devices comprising the balanced amplifier. In our approach, the injected control signal is used both as an active match and to dynamically load modulate the main devices to provide efficiency enhancement at back-off, thus extending the dynamic range compared to the original LMBA formulation. In this paper, we introduce a phase-compensation technique through which the active matching and load modulation tracks the frequency-dependent optimal loading trajectory of a packaged device. The result is a load-modulation power amplifier architecture able to perform an active, modulated match over an octave bandwidth. The technique is demonstrated over 1.8-3.8 GHz using packaged devices and an off-the-shelf hybrid coupler. The proof-of-concept octave RF-input LMBA has a peak CW output power of 44 dBm, with power added efficiency (PAE) over the 1.8-3.8 GHz operating frequency range of 37%-59% at peak power and 29%-45% at 6-dB output backoff. The RF-input nature of this architecture enables straightforward measurement with modulated signals; a W-CDMA signal at 3.8 GHz with 9-dB (measured) peak to average power ratio is demonstrated with adjacent channel leakage ratio of -30 dBc and average PAE of 18% for a 31-dBm average output power (2-dB backoff).
Systemic Gene Transfer to Skeletal Muscle Using Reengineered AAV Vectors (2010)

Gene therapy of musculoskeletal disorders warrants efficient gene transfer to a wide range of muscle groups. Reengineered adeno-associated viral (AAV) vectors that selectively transduce muscle tissue following systemic administration are attractive candidates for such applications. Here we provide examples of several lab-derived AAV vectors that display systemic tissue tropism in mice. Methods to evaluate the efficiency of gene transfer to skeletal muscle following intravenous or isolated limb infusion of AAV -vectors in mice are discussed in detail.
Reliability Issues in Computing System Design (1978)

article Reliability Issues in Computing System Design Share on Authors: B. Randell Computing Laboratory, University of Newcastle upon Tyne, Newcastle upon Tyne, NE1 7RU UK Computing Laboratory, University of Newcastle upon Tyne, Newcastle upon Tyne, NE1 7RU UKView Profile , P. Lee Computing Laboratory, University of Newcastle upon Tyne, Newcastle upon Tyne, NE1 7RU UK Computing Laboratory, University of Newcastle upon Tyne, Newcastle upon Tyne, NE1 7RU UKView Profile , P. C. Treleaven Computing Laboratory, University of Newcastle upon Tyne, Newcastle upon Tyne, NE1 7RU UK Computing Laboratory, University of Newcastle upon Tyne, Newcastle upon Tyne, NE1 7RU UKView Profile Authors Info & Claims ACM Computing SurveysVolume 10Issue 2June 1978 pp 123–165https://doi.org/10.1145/356725.356729Published:01 June 1978 293citation3,547DownloadsMetricsTotal Citations293Total Downloads3,547Last 12 Months42Last 6 weeks3 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Investigation of Harmonic Content in Chain-Link STATCOM With a Non-Integer Frequency Modulation Index (2015)

The technology around multilevel converters has emerged in the past decades and many new topologies have been introduced. Many multilevel converter topologies are equipped with floating capacitors which, if not controlled properly, face serious voltage imbalance issues. These issues are a result of the harmonic distortion in the output current and voltage. By proper choice of modulation technique, the harmonic performance of a multilevel converter can be significantly improved. One of the modulation techniques that improves the harmonic performance is the PS-PWM. However, this method does not eliminate the voltage imbalance issue that cause the capacitors to deviate, which leads to a need for additional individual balancing controllers. It has been concluded that a non-integer modulation frequency index significantly improves the imbalance problem by slowing down the deviation process during non-ideal conditions and almost completely preventing it during ideal conditions. In this thesis, the affect of a non-integer modulation frequency index voltage balancing in a modular multilevel converter with PS-PWM has been investigated. The harmonic behavior has been derived analytically and verified through PSCAD simulations.
Factors influencing the development of an anti–factor IX (FIX) immune response following administration of adeno-associated virus–FIX (2001)

The present study sought to determine the impact of the route of administration of an adeno-associated virus (AAV) vector encoding human factor IX (hFIX) on the induction of an immune response against the vector and its xenogenic transgene product, hFIX. Increasing doses of AAV-hFIX were administered by different routes to C57Bl/6 mice, which typically demonstrate significant immune tolerance to hFIX. The route of delivery had a profound impact on serum hFIX levels as well as the induction of an anti-hFIX humoral immune response. At all dose levels tested, delivery of AAV-hFIX by an intramuscular (IM) route induced an antibody response against the human FIX protein and no hFIX was detected in the serum of animals even at doses of 2 x 10(11) DNA viral particles (vp) of AAV-hFIX. This was in stark contrast to the mice that received AAV-hFIX by intraportal vein (IPV) administration. No anti-hFIX inhibitors were observed in any of these mice and therapeutic levels of hFIX were detected in the serum of all mice that received doses of 2 x 10(10) vp AAV-hFIX and higher. When pre-existing neutralizing immunity to AAV was established in mice, AAV-hFIX administration by either the IM or IPV routes did not result in detectable serum hFIX. Although hFIX expression was not observed in mice with pre-existing neutralizing immunity to AAV, an anti-hFIX response was induced in all of the animals that received AAV-hFIX by the IM route. This was not observed in the preimmune mice that received AAV-hFIX by IPV administration. These results suggest that the threshold of inducing an immune response against a secreted transgene product, in this case the xenoprotein hFIX, is lower when the vector is administered by the IM route even in animals with pre-existing immunity to AAV. (Blood. 2001;97:3733-3737)
Attitudes and experience of Singapore doctors and dental surgeons regarding acquired immunodeficiency syndrome (AIDS) and human immunodeficiency virus (HIV) positive patients. (1989)

A survey conducted in September 1987 among medical doctors and dental surgeons in Singapore found that most respondents expressed personal reservations and inadequacies in dealing with AIDS/HIV-positive patients and homosexuals. They were also concerned about exposure of their staff to AIDS patients and their likely reactions towards treating these patients. The risk of contagion with AIDS was a major deterrent expressed. The majority of the health professionals had no experience in the management of AIDS related conditions. Although many indicated interest in training, only less than half were willing to undergo what they perceived as the more effective clinically based training themselves.
A cautionary tale : settlements on behalf of minors : litigation (2013)

The Supreme Court of Appeal (SCA) delivered judgement on May 29 in a case that many had been hoping would provide clarity in an area of law recently under the spotlight.
Alogliptin added to insulin therapy in patients with type 2 diabetes reduces HbA <sub>1c</sub> without causing weight gain or increased hypoglycaemia (2009)

Adding alogliptin to previous insulin therapy (with or without metformin) significantly improved glycaemic control in patients with type 2 diabetes inadequately controlled on insulin, without causing weight gain or increasing the incidence of hypoglycaemia. Further studies are warranted to explore the role of alogliptin added to optimized basal insulin regimens.
Cellulase and Xylanase Release from <i>Bacteroides succinogenes</i> and Its Importance in the Rumen Environment (1981)

During growth of Bacteroides succinogenes in a liquid medium with cellulose as the source of carbohydrate, greater than 80% of the carboxymethylcellulase (endo-beta-1,4-glucanase), xylanase, and aryl-beta-xylosidase and 50% of the aryl-beta-glucosidase released from cells into the culture fluid. Less than 25% of the cellobiase activity was detected in the culture fluid. Approximately 50% of each of the released enzymes measured was associated with sedimentable subcellular membrane vesicles. The vesicles appeared to be released from the outer membrane of intact cells by bleb formation, primarily in pockets between the cells and the cellulose, although a few unattached cells with blebs were seen. Many vesicles were seen adhering to cellulose, and they were also seen free in the culture fluid. These data suggest that B. succinogenes releases hydrolytic enzymes in nonsedimentable and particulate forms during growth by a mechanism which has until now received little attention. Cellulose incubated in a porous nylon bag in the rumen was colonized by bacteria resembling B. succinogenes, and subcellular vesicles were seen penetrating channels and fractures in the cellulose. On this basis, it is suggested that B. succinogenes cells in the rumen contribute to an extracellular population of subcellular vesicles that possess cellulolytic and hemicellulolytic activities which probably enhance polymer digestion and provide a source of sugars for microbes lacking polymer-degrading activity, thereby contributing to a stable heterogeneous microbial population.
A MUltidimensional Compliant Decoupled Actuator (MUCDA) for Pelvic Support During Gait (2018)

Series Elastic Actuation decouples actuator inertia from the interaction ports and is thus advantageous for force-controlled devices. Parallel or even passive compliance can fulfill a complementary role by compensating for gravitational or periodic inertial forces or by providing passive guidance. Here, these concepts are combined in an underactuated six degree of freedom (6-DoF) compliant manipulator with one actuated DoF. The mechanism comprises a spring assembly in which each spring serves as an actuation element and simultaneously provides passive compliance in the unactuated DoF. The device is designed to assist weight shifting via controlled lateral forces on a human pelvis during treadmill walking and its eigenfrequencies are tuned to align with normal gait. 6-DoF force and torque sensing are realized via a model of the spring deformation characteristics in combination with low-cost inertial and optical sensors. Experimental evaluation demonstrates that the system can effectively follow physiological lateral pelvis movement with low interaction forces and also has little impact on remaining pelvis motions.
Mapping Soil Organic Carbon Concentration for Multiple Fields with Image Similarity Analysis (2008)

Remotely sensed imagery with high spatial resolution has been used to map soil organic carbon (SOC) concentrations at a field scale with greatly increased accuracy and reduced cost compared with grid sampling. The procedure, however, requires each crop field to be sampled and mapped separately. The purpose of this study was to determine if cost could be reduced further by grouping a number of crop fields based on their image similarity, and then mapping them together as one group. Ten crop fields with a bare soil surface were selected from a 2000 NASA ATLAS image. The similarity among these fields was examined with the Ward neural network system (WNNS) using the image histogram features extracted from the image for each field. Seven fields were placed into two groups based on the coefficient of determination ( R 2 ) values computed from WNNS, with one group consisting of three fields and the second consisting of four fields. Soil samples were taken from the seven fields along with their global positioning system locations and were divided into two data sets, with one for model development and the other for result checking. Models for mapping SOC concentrations were developed for each group of fields using a single procedure. The resulting maps were checked based on soil sample sets that were not used in model development and showed good agreement between mapped values and lab‐determined values, with r 2 values of 0.80 for one group of fields and 0.77 for the second group of fields. The models were greatly improved compared with the model developed for all seven fields ( R 2 was 0.87 and 0.91 for two groups vs. 0.63 for all fields and RMSE was 0.108 and 0.143 vs. 0.219 of SOC percentage). The model developed with similarity grouping was also compared with the model for field‐by‐field mapping and showed close agreement ( R 2 was 0.87 for Group 1 vs. 0.89 for Field 2 only in Group 1 and RMSE was 0.108 vs. 0.119 for the same field).