gebhart/patrepeval huggingface dataset:
The developmental pattern of androgen receptor expression in rat prostate lobes is altered after neonatal exposure to estrogen (1995)

Brief administration of estrogen to newborn rats permanently imprints adult prostatic androgen receptor (AR) expression in a lobe-specific manner. To delineate this effect, we examined the immediate effects of early estrogen exposure on the changing AR pattern in the developing ventral, dorsal, and lateral prostate lobes. Antibodies against rat AR (PG-21) were used in combination with several antibodies to cell-specific antigens for positive cellular identification by immunocytochemistry. At birth, mesenchymal cells of the ventral prostate were strongly AR positive (AR+). Epithelial cells stained only for basal cell cytokeratins and, in contrast to earlier reports, many were AR+ on day 1. Between days 3-5, periductal mesenchymal cells differentiated into smooth muscle cells which retained strong AR+ staining, whereas interductal fibroblasts exhibited a decreased incidence of AR+ cells. Between days 5-10, luminal epithelial cells first appeared, and a striking increase in AR staining intensity was noted relative to that in the basal cells. During puberty, basal cells lost their AR immunoreactivity. Similar changes were observed in the dorsal and lateral lobes. Newborn rats were given 25 micrograms estradiol benzoate on days 1, 3, and 5 and were killed thereafter. By day 6, AR staining was markedly decreased to a weak to moderate intensity in all cell types, and by day 10, AR was virtually absent in the separate lobes. Growth and epithelial cytodifferentiation were significantly retarded. Between days 15-30, evidence of luminal cell cytodifferentiation was noted; however, this was frequently not associated with an increase in AR staining. In the ventral and dorsal lobes, a continuous peripheral layer of AR-negative basal cells surrounded the ducts in the central and proximal regions, and this was associated with a permanent inability of luminal epithelial cells to express AR. Epithelial and smooth muscle AR expression was observed only in the distal tips. In contrast, AR expression rapidly returned in all regions of the lateral lobes, except the proximal ducts. We conclude that 1) basal epithelial cells express AR as early as day 1 of life and should be considered as possible direct targets of androgen action during prostate morphogenesis; 2) differentiation into luminal cells is associated with an increase, rather than an induction, of AR expression; and 3) periductal smooth muscle cells retain strong AR expression throughout development and should be considered primary targets for androgen-mediated morphogenesis. Neonatal estrogen initially down-regulates AR expression in all cells of three lobes, which may explain the overall growth retardation.
On the performance of the VESPA algorithm for blind beamforming and signal detection of multi-source multipath signals (2003)

The higher order statistics based VESPA (virtual ESPRIT algorithm) has been shown to be a very powerful technique for blind beamforming and signal detection. It can detect coherent signals. Also, it is shown that that it can detect uncorrelated signals better than classical methods. Thus, this technique can be efficiently used in some severe situations such as multi-user signals propagating in multipath media using arrays of arbitrary configurations.
Probing Electronic Transitions in Individual Carbon Nanotubes by Rayleigh Scattering (2004)

Rayleigh scattering spectra were obtained from individual single-walled carbon nanotubes with the use of a laser-generated visible and near-infrared supercontinuum. This diagnostic method is noninvasive and general for nanoscale objects. The approach permits clear identification of excited states in arbitrary metallic and semiconducting nanotubes. We analyzed spectral lineshapes in relation to the role of excitonic effects and correlated the results with Raman scattering data on individual tubes. The nanotube structure remained the same over distances of tens of micrometers. Small nanotube bundles retained distinct Rayleigh spectroscopic signatures of their component nanotubes, thus allowing the probing of nanotube-nanotube interactions.
Advanced control of chemical processes 2000 (ADCHEM 2000) : a proceedings volume from the IFAC symposium, Pisa, Italy, 14-16 June, 2000 (2001)

This Proceedings contains the papers presented at the IFAC Symposium on Advanced Control of Chemical Processes held in Pisa on 14 - 16 June 2000. This proceedings consists of three volumes with broad topic areas of: modeling and simulation, model based control, realtime optimization, process and control monitoring, process identification and process control applications and plantwide control. The specific papers' subjects range from the specific to the general, ranging from general fault diagnosis to specific problems which affect the chemical industries.
A Fast Clustering-Based Feature Subset Selection Algorithm for High-Dimensional Data (2011)

Feature selection involves identifying a subset of the most useful features that produces compatible results as the original entire set of features. A feature selection algorithm may be evaluated from both the efficiency and effectiveness points of view. While the efficiency concerns the time required to find a subset of features, the effectiveness is related to the quality of the subset of features. Based on these criteria, a fast clustering-based feature selection algorithm (FAST) is proposed and experimentally evaluated in this paper. The FAST algorithm works in two steps. In the first step, features are divided into clusters by using graph-theoretic clustering methods. In the second step, the most representative feature that is strongly related to target classes is selected from each cluster to form a subset of features. Features in different clusters are relatively independent, the clustering-based strategy of FAST has a high probability of producing a subset of useful and independent features. To ensure the efficiency of FAST, we adopt the efficient minimum-spanning tree (MST) clustering method. The efficiency and effectiveness of the FAST algorithm are evaluated through an empirical study. Extensive experiments are carried out to compare FAST and several representative feature selection algorithms, namely, FCBF, ReliefF, CFS, Consist, and FOCUS-SF, with respect to four types of well-known classifiers, namely, the probability-based Naive Bayes, the tree-based C4.5, the instance-based IB1, and the rule-based RIPPER before and after feature selection. The results, on 35 publicly available real-world high-dimensional image, microarray, and text data, demonstrate that the FAST not only produces smaller subsets of features but also improves the performances of the four types of classifiers.
Investigations on the long-term behavior and switching function of fuse-elements for NH-fuse-links (gG) at higher thermal stress (2017)

In electrical power grids NH-fuse-links (gG) are widely used to protect electrical devices in case of overloads or shorts-circuit currents. New requirements of modern power grids, especially in the context of a growing share of renewable energies, implicate a much higher thermal stress level of the fuse-links. This can lead to an accelerated ageing of the fuse-elements, mainly due to the temperature-dependent ageing mechanisms of interdiffusion. The results are failures like unintended tripping or even a failed tripping of fuse-links. These failures reduce the security of supply, which is expected from the grid, and cause a major economic damage due to the high numbers of fuse-links used in the grid. Thereby the maximum temperature of the fuse-element is the most important criterion for a long-term stable use of fuse-links. Thus current research focuses on the investigation of the long-term behavior of such fuse-elements at higher thermal stress levels. Therefore the fuse-element's temperature distribution at normal operating conditions is investigated as well as extensive long-term experiments with several common used fuse-element types at different thermal stress levels are performed. The paper presents the considerations, on which the experiments are done, and the results of the long-term experiments. Further, a test stand for tripping tests of fuse-elements and first results of tripping tests with new fuse-elements are presented. With that, the impact of the ageing, due to the long-term thermal treatment, on the proper functioning of the fuse-elements should be evaluated and based on that results, conclusions for future limiting temperatures for fuse-elements should be drawn.
Design and evaluation of MiMaze a multi-player game on the Internet (2002)

This paper describes the design, implementation, and evaluation of MiMaze, a distributed multiplayer game on the Internet. The major contribution of this work is to have designed and implemented a completely distributed communication architecture based on IP multicast. MiMaze uses multicast communication system based on RTP/UDP/IP, and distributed synchronization mechanisms to guarantee the consistency of the game, regardless of network delay. This paper provides evaluation results on the Mbone.
Comparison of the effects of high- and low-methoxyl pectins on blood and faecal lipids in man (1982)

The effects on blood and faecal lipids of the addition of 15 g of either high- or low-methoxyl pectin to the habitual diets of ten healthy young adults have been studied. 2. Serum total cholesterol levels were reduced by a mean of 16% during consumption of low-methoxyl pectin and 18% during consumption of high-methoxyl pectin. High density lipoprotein cholesterol levels and triglyceride levels were unchanged. 3. There was no difference in faecal fat and steroid excretion between the two pectins. 4. The results suggest that it is the gel-forming properties of the pectins which are important in the cholesterol-lowering effect rather than differences in bile acid binding due to different methoxyl contents.
A new type of transparent and low cost counter-electrode based on platinum nanoparticles for dye-sensitized solar cells (2011)

Here we report on the fabrication of a new low-cost transparent cathode based on platinum nanoparticles prepared by a bottom-up synthetic approach. Scanning Electron Microscope (SEM) images showed the platinum nanoparticles homogeneously distributed on a fluorine doped tin oxide conductive glass surface. We demonstrated that, with such a type of cathode, the solar energy conversion efficiency is the same as that obtained with a platinum sputtered counter-electrode, and is more than 50% greater than that obtained with a standard electrode, i.e. one prepared by chlorine platinum acid thermal decomposition, in similar working conditions. Using a special back-reflecting layer of silver, we improved upon the performance of a counter-electrode based on platinum sputtering, achieving an overall solar conversion efficiency of 4.75% at 100 mW cm−2 (AM 1.5) of simulated sunlight.
Dissecting and Reducing the Heterogeneity of Excited-State Energy Transport in DNA-Based Photonic Wires (2006)

Molecular photonic wires are one-dimensional representatives of a family of nanoscale molecular devices that transport excited-state energy over considerable distances in analogy to optical waveguides in the far-field. In particular, the design and synthesis of such complex supramolecular devices is challenging concerning the desired homogeneity of energy transport. On the other hand, novel optical techniques are available that permit direct investigation of heterogeneity by studying one device at a time. In this article, we describe our efforts to synthesize and study DNA-based molecular photonic wires that carry several chromophores arranged in an energetic downhill cascade and exploit fluorescence resonance energy transfer to convey excited-state energy. The focus of this work is to understand and control the heterogeneity of such complex systems, applying single-molecule fluorescence spectroscopy (SMFS) to dissect the different sources of heterogeneity, i.e., chemical heterogeneity and inhomogeneous broadening induced by the nanoenvironment. We demonstrate that the homogeneity of excited-state energy transport in DNA-based photonic wires is dramatically improved by immobilizing photonic wires in aqueous solution without perturbation by the surface. In addition, our study shows that the in situ construction of wire molecules, i.e., the stepwise hybridization of differently labeled oligonucleotides on glass cover slides, further decreases the observed heterogeneity in overall energy-transfer efficiency. The developed strategy enables efficient energy transfer between up to five chromophores in the majority of molecules investigated along a distance of approximately 14 nm. Finally, we used multiparameter SMFS to analyze the energy flow in photonic wires in more detail and to assign residual heterogeneity under optimized conditions in solution to different leakages and competing energy-transfer processes.
Sc3p Hydrophobin Organization in Aqueous Media and Assembly onto Surfaces As Mediated by the Associated Polysaccharide Schizophyllan (2000)

Sc3p is the major hydrophobin produced and excreted by the wood-rotting fungus Schizophyllum commune when grown as a monokaryon in culture. In addition to Sc3p, several lower molecular weight proteins of unknown function and a high molecular weight polysaccharide, schizophyllan, are present in this fungal culture medium. Previous studies in our laboratory indicated that schizophyllan and hydrophobin, as produced in the culture supernatant, work in concert to ultimately produce stable films on hydrophilic substrates. We report a new procedure for isolation of hydrophobin that does not require treatment with strong organic acids. This procedure allows a systematic evaluation of the importance of the individual hydrophobin and schizophyllan components in solution stabilization and film formation from a conformational state more representative of that found during fungal production. Experimental results indicate that schizophyllan stabilizes small hydrophobin multimers in aqueous solution. In addition, schizophyllan is necessary for subsequent hydrophobin assembly into films on hydrophilic surfaces. By contrast, hydrophobin alone is sufficient for thin film assembly onto a hydrophobic surface; however, hydrophobin aggregation at high protein concentration in the absence of schizophyllan may limit the efficiency of film formation. A model has been proposed in which the polysaccharide acts as a hydrophilic stabilizer of hydrophobin in solution preventing self-aggregation. The schizophyllan-stabilized complex may also allow conformational mobility for lateral reorganization during deposition and film coalescence.
D-aspartic acid is implicated in the control of testosterone production by the vertebrate gonad. Studies on the female green frog, Rana esculenta (1998)

In the present study we report the occurrence of D-aspartic acid (D-Asp) in the ovary of the green frog Rana esculenta and its putative involvement in testosterone production by the gonad. In the ovary, D-Asp concentrations undergo significant variations during the main phases of the sexual cycle. In spawning females (March), its concentration was low (2.5 +/- 1.1 nmol/g ovary) and during the post-reproductive period (June) it increased and reached its peak level (58.0 +/- 10.1 nmol/g) in October. In that month, vitellogenesis occurs in a new set of ovarian follicles and continues until the next spring. The concentrations of D-Asp in the ovary and of testosterone in the ovary and in the plasma were inversely correlated during the reproductive cycle: when endogenous D-Asp was low (March), testosterone was high (36.9 +/- 4.8 ng/g ovary; 23.1 +/- 2.76 ng/ml plasma) and, in contrast, when the D-Asp concentration was high (October), the testosterone concentration was low (0.86 +/- 0.21 ng/g ovary and 5.0 +/- 1.3 ng/ml plasma). In vivo experiments, consisting of injection of D-Asp (2.0 mumol/g body weight) into the dorsal lymphatic sac of adult female frogs, demonstrated that this amino acid accumulates significantly in the ovary. After 3 h, moreover, it caused a decrease in testosterone level in the plasma of about 80%. This inhibition was reversible: within 18 h after the amino acid injection, as the D-Asp concentration in the ovary decreased, the testosterone titre was restored in both ovary and plasma. In vitro experiments, conducted in isolated ovarian follicles, confirmed this phenomenon and identified these gonadal components as the putative D-Asp targets. Other amino acids (L-Asp, D-Glu, L-Glu, D-Ala and L-Ala) used instead of D-Asp were ineffective. These findings indicate that D-Asp is involved in the control of androgen secretion by the ovary in this amphibian species, revealing a more complex system for control of this androgen synthesis than was previously believed to exist.
Hypersensitivity to sound (hyperacusis): a prevalence study conducted via the internet and post: Hipersensibilidad al sonido (hiperacusia): un estudio de prevalencia realizado por internet y por correo (2002)

The present study explored the prevalence and descriptive characteristics of hyperacusis, defined as unusual intolerance of ordinary environmental sounds. Two ways of collecting data were used in the study: the first was a postal survey of a random sample, to which 589 responded (59.7% response rate); the second was the internet, and 595 self-recruited individuals responded to a call for participants via a banner on a web page (51.9% response rate). The point prevalence rates of hyperacusis were 9% in the internet group and 8% in the postal group. Exclusion of participants who reported hearing impairment resulted in point prevalence rates of 7.7% (n = 39) and 5.9% (n = 28) respectively. The data collection format did not result in any substantial differences. Hyperacusis was associated with concentration difficulties, use of ear protection, avoidance, tension, and sensitivity to light/colours. The present data suggest that hyperacusis is a common problem.
Cationic aluminium hydrides: [H<sub>2</sub>AlL]<sup>+</sup>[AlH<sub>4</sub>]<sup>–</sup>, L =N,N,N′,N″,N″-pentamethyldiethylenetriamine and 1,4,8,11-tetramethyl-1,4,8,11-tetraazacyclotetradecane (1991)

Reaction of H3AlNMe3 with N,N,N′,N″,N″-pentamethyldiethylenetriamine (pmdien) in diethyl ether or 1,4,8,11-tetramethyl-1,4,8,11-tetraazacyclotetradecane (Me4cyclam) in tetrahydrofuran yields [H2Al(pmdien)]+[AlH4]–, which possesses a trigonal bipyramidal cation with the hydrides in the trigonal plane [Al–N′ 2.158(7), Al–N,N″ 2.01(1), Al–H 1.62 Å] or [H2Al(Me4 cyclam)]+[AlH4], where the metal centre in the cation is trans-octahedral [Al–N(mean) 2.13, Al–H 1.60, 1.64 Å].
Substrate-dependent competition of different P 450 isoenzymes for limiting NADPH-cytochrome P 450 reductase (1995)

The goal of these studies was to demonstrate that one P450 isozyme can influence the function of another isozyme when combined in a reconstituted system. Benzphetamine and 7-pentoxyresorufin were both shown to be preferred substrates for P450 2B4 (LM2) as compared to P450 1A2 (LM4). However, these substrates exhibited different characteristics when examined in reconstituted systems containing reductase and both P450 isozymes. Whereas benzphetamine demethylation showed a small increase in catalytic activity when both P450 1A2 and 2B4 were present over the activities obtained in simple reconstituted systems, 7-pentoxyresorufin O-dealkylation (PROD) was dramatically inhibited when both isozymes were present. These results indicate that the functional interactions between P450s in complex reconstituted systems are dependent on the substrate present. Inhibition of PROD was also dependent on reductase levels, with the inhibitory effect being more pronounced at subsaturating reductase. Finally, these protein-protein interactions were shown to be dependent on the reductase concentration in the reconstituted system rather the P450 concentration, supporting the view that P450 1A2 is inhibiting the reaction by competing with P450 2B4 for reductase molecules.
Relationships between Haemostatic Factors and Capillary Morphology in Human Diabetic Neuropathy (1992)

We have examined haemostatic factors in 15 diabetic patients with peripheral neuropathy and 10 diabetic patients without clinical complications. Plasma and blood viscosity, fibrinogen, factor VIIIc, von Willebrand factor activity, spontaneous platelet aggregation and fibrinolytic activity were not significantly different between diabetic patients without clinical complications and diabetic patients with peripheral neuropathy. Platelet aggregation was enhanced in diabetic patients with neuropathy compared with those without complications. In the 15 patients with neuropathy and 3 without complications, who underwent biopsy of sural nerve, skin and muscle, associations were found between haemostatic variables and measures of nerve capillary pathology, notably: plasma fibrinogen and nerve capillary basement membrane thickness (r = 0.70, p < 0.001); thromboxane B2 production and nerve capillary basement membrane thickness (r = -0.61, p < 0.01); plasma fibrinolytic activity and endoneurial capillary lumen size (r = 0.60, p < 0.01) and endothelial cell outer perimeter (r = 0.65, p < 0.01). The main associations of skin and muscle capillary abnormalities were with measures of in vitro platelet aggregation, and the correlations found with nerve capillary measurements were not echoed in the overlying muscle and skin. The results are supportive of the involvement of haemostatic abnormalities in the pathogenesis of diabetic neuropathy.
Significance of Polypyrimidine Tract–Binding Protein 1 Expression in Colorectal Cancer (2015)

Polypyrimidine tract-binding protein (PTBP1) is an RNA-binding protein with various molecular functions related to RNA metabolism and a major repressive regulator of alternative splicing, causing exon skipping in numerous alternatively spliced pre-mRNAs. Here, we have investigated the role of PTBP1 in colorectal cancer. PTBP1 expression levels were significantly overexpressed in cancerous tissues compared with corresponding normal mucosal tissues. We also observed that PTBP1 expression levels, c-MYC expression levels, and PKM2:PKM1 ratio were positively correlated in colorectal cancer specimens. Moreover, PTBP1 expression levels were positively correlated to poor prognosis and lymph node metastasis. In analyses of colorectal cancer cells using siRNA for PTBP1, we observed that PTBP1 affects cell invasion, which was partially correlated to CD44 splicing, and this correlation was also confirmed in clinical samples. PTBP1 expression also affected anchorage-independent growth in colorectal cancer cell lines. PTBP1 expression also affected cell proliferation. Using time-lapse imaging analysis, PTBP1 was implicated in prolonged G2-M phase in HCT116 cells. As for the mechanism of prolonged G2-M phase in HCT116 siPTBP1 cells, Western blotting revealed that PTBP1 expression level was correlated to CDK11(p58) expression level, which was reported to play an important role on progression to complete mitosis. These findings indicated that PTBP1 is a potential therapeutic target for colorectal cancer.
Single-mode mid-IR guidance in a hollow-core photonic crystal fiber (2005)

We report, for the first time, bandgap guidance above 3 mum in a silica based air-core photonic crystal fiber. The peak of the bandgap is at 3.14mum with a typical attenuation of ~ 2.6 dB m-1. By further optimization of the structure, modeling suggests that a loss below 1 dB m-1 should be achievable, greatly extending the useful operating range of silica-based single-mode fibers. Such fibers have many potential applications in the mid-IR, offering an alternative to fluoride, tellurite or chalcogenide glass based optical fibers for chemical and biological sensing applications.