gebhart/patrepeval huggingface dataset:
Effects of the high K+/Na+ deficient solution on mechanical response and wet weight of tissue in vas deferens and seminal vesicle in guinea-pig. (1988)

In the present experiments, we investigated contractions of guinea-pig vas deferens or seminal vesicle in various kinds of high K+ solution. The vas deferens showed a phasic contraction followed by a tonic one in hyperosmotic 65 mM KCl (hyper-65K+), isosmotic 60 mM or 120 mM KCl solution. However, isosmotic 154 mM KCl (iso-154K+) solution induced a large phasic contraction followed by a gradual relaxation. Applications of the high K+ solutions to the preparation of seminal vesicle showed almost similar results in tension to those of the vas deferens. In the vas deferens or seminal vesicle, an application of hyper-65K+ solution significantly decreased the relative value for the wet weight of the tissue at 120 min, but that of iso-154K+ solution did not affect the wet weight of both the muscles. In the vas deferens, an hyperosmotic addition of sucrose at a concentration of 25 to 100 mM slightly prevented the tension decreased by the iso-154K+ solution and slightly decreased the relative wet weight. In the seminal vesicle, increasing sucrose concentration significantly increased the tension, but decreased the relative wet weight. In both the muscles of vas deferens and seminal vesicle, an addition of pyrvate or oxalacetate (5.5 mM) to the iso-154K+ solution without glucose maintained the muscle tension at a maximal level in the iso-154K+ solution with glucose for 120 min. Further, the tension decrease in both the muscles induced by iso-154K+ solution was also prevented by hyperosmotic application of NaCl. From these results, it is suggested that the tension decrease by high K+, Na+-deficient solution in the vas deferens is mainly caused by an inhibition of glucose utilization by Na+-deficiency in the medium, however, the seminal vesicle is probably due to the cell swelling and partly the inhibition of glucose utilization by it.
Role of Resins on Asphaltene Stability (2009)

The objective of this study is to clarify through impedance analysis some of the controversial issues related to the role of resins on asphaltene stability. From the variations of the direct-current (DC) conductivity of charge carriers in petroleum fluids with their concentration in toluene, we find that resins are unlikely to coat asphaltene nanoaggregates within the concentration range investigated (10−1000 ppm). Thus, the long-time-standing Nellensteyn hypothetical model, where resins adsorb on asphaltenes to provide a steric stabilizing layer, is not valid. In heptane/toluene mixtures, the least soluble resins tend to aggregate with asphaltenes to enhance their stability in the mixture, in agreement with a recently proposed molecular thermodynamic approach to the formation of mixed asphaltene−resin aggregates (Rogel, E. Molecular thermodynamic approach to the formation of mixed asphaltene−resin aggregatesEnergy Fuels 2008, 22 (6), 3922−3929).
Why intramuscular methotrexate may be more efficacious than oral dosing in patients with rheumatoid arthritis (1997)

In order to compare the relative bioavailability of orally administered methotrexate (MTX) with i.m. administration in patients with rheumatoid arthritis, we compared the pharmacokinetics of MTX at both the usual starting dose of 7.5 mg and at higher established maintenance dosages in 21 patients. Pharmacokinetic measures were repeated approximately 6 and 18 months after baseline while patients consumed their usual maintenance doses of MTX (17.0 +/- 3.8 mg). The relative bioavailability of the usual maintenance dose of MTX was reduced by 13.5% compared with the initial dose of 7.5 mg (P = 0.026). Area under the serum concentration vs time curve (AUC) was significantly reduced with oral vs i.m. administration at usual maintenance doses (decrease of 0.729 mumol.h/l by oral administration, P = 0.027), but not at a 7.5 mg dose of MTX. Clinicians using MTX should not assume constant and complete bioavailability across the dose range used to treat patients with rheumatoid arthritis. Our observations explain the reported clinical success of switching from an oral to a parenteral route of administration in patients receiving maintenance doses of MTX.
Estimating the Null and the Proportion of Nonnull Effects in Large-Scale Multiple Comparisons (2007)

An important issue raised by Efron in the context of large-scale multiple comparisons is that in many applications, the usual assumption that the null distribution is known is incorrect, and seemingly negligible differences in the null may result in large differences in subsequent studies. This suggests that a careful study of estimation of the null is indispensable. In this article we consider the problem of estimating a null normal distribution, and a closely related problem, estimation of the proportion of nonnull effects. We develop an approach based on the empirical characteristic function and Fourier analysis. The estimators are shown to be uniformly consistent over a wide class of parameters. We investigate the numerical performance of the estimators using both simulated and real data. In particular, we apply our procedure to the analysis of breast cancer and human immunodeficiency virus microarray datasets. The estimators perform favorably compared with existing methods.
Cerebral Function Monitoring During Carotid Endarterectomy (1989)

Log in or Register Subscribe to journalSubscribe Get new issue alertsGet alerts Enter your Email address: Wolters Kluwer Health may email you for journal alerts and information, but is committed to maintaining your privacy and will not share your personal information without your express consent. For more information, please refer to our Privacy Policy. Subscribe to eTOC Secondary Logo Journal Logo All Articles Images Videos Podcasts Blogs Advanced Search Toggle navigation Subscribe Register Login Articles & Issues Current IssuePrevious IssuesPublished Ahead-of-Print Collections SNACC Clinical Guidelines and Consensus StatementsSNACC Abstracts For Authors Submit a ManuscriptInformation for AuthorsLanguage Editing ServicesAuthor Permissions Journal Info About the JournalEditorial BoardAffiliated SocietiesAdvertisingOpen AccessSubscription ServicesReprintsRights and Permissions All Articles Images Videos Podcasts Blogs Advanced Search
Response to chemotherapy and expression of the genes encoding the multidrug resistance-associated proteins MRP2, MRP3, MRP4, MRP5, and SMRP in childhood acute myeloid leukemia. (2003)

This study provides first data on the clinical relevance of five MRPs in acute myeloid leukemia patients. The results strongly suggest that MRP3 and possibly also MRP2 are involved in drug resistance in this disease. Those two proteins therefore represent interesting markers for risk-adapted therapy and possible targets for the development of specific drugs to overcome multidrug resistance.
Oligophenylene 2,4,6-triarylpyridines and analogous diaza-p-terphenyls, diaza-p-quaterphenyls and diaza-p-quinquephenyls with luminiscent activity (1989)

Cyclocondensation of α,β-unsaturated aromatic ketones V and VIII with quaternary pyridinium salts VI in the presence of ammonium acetate gave 2,4,6-triarylpyridines I , aryl-substituted diaza- p -terphenyls IIa,b , diaza- p -quaterphenyls IIc,d and diaza- p -quinquephenyls IIe,f . All the new polyphenylene compounds exhibit characteristic luminiscence in the visible spectral region.
The Siderocalin/Enterobactin Interaction: A Link between Mammalian Immunity and Bacterial Iron Transport<sup>1</sup> (2008)

The siderophore enterobactin (Ent) is produced by enteric bacteria to mediate iron uptake. Ent scavenges iron and is taken up by the bacteria as the highly stable ferric complex [Fe (III)(Ent)] (3-). This complex is also a specific target of the mammalian innate immune system protein, Siderocalin (Scn), which acts as an antibacterial agent by specifically sequestering siderophores and their ferric complexes during infection. Recent literature suggesting that Scn may also be involved in cellular iron transport has increased the importance of understanding the mechanism of siderophore interception and clearance by Scn; Scn is observed to release iron in acidic endosomes and [Fe (III)(Ent)] (3-) is known to undergo a change from catecholate to salicylate coordination in acidic conditions, which is predicted to be sterically incompatible with the Scn binding pocket (also referred to as the calyx). To investigate the interactions between the ferric Ent complex and Scn at different pH values, two recombinant forms of Scn with mutations in three residues lining the calyx were prepared: Scn-W79A/R81A and Scn-Y106F. Binding studies and crystal structures of the Scn-W79A/R81A:[Fe (III)(Ent)] (3-) and Scn-Y106F:[Fe (III)(Ent)] (3-) complexes confirm that such mutations do not affect the overall conformation of the protein but do weaken significantly its affinity for [Fe (III)(Ent)] (3-). Fluorescence, UV-vis, and EXAFS spectroscopies were used to determine Scn/siderophore dissociation constants and to characterize the coordination mode of iron over a wide pH range, in the presence of both mutant proteins and synthetic salicylate analogues of Ent. While Scn binding hinders salicylate coordination transformation, strong acidification results in the release of iron and degraded siderophore. Iron release may therefore result from a combination of Ent degradation and coordination change.
Synthese de pyrrolo[1,2‐<i>a</i>]quinoleines (1991)

Abstract Les 4‐acétoxy pyrrolo[1,2‐ a ]quinoléines 26‐30 sont accessibles par cyclisation des acides 2‐(1‐pyrrole)phénylacétiques 21‐25 par chauffage dans l'anhydride acétique. Les chlorures d'acides 11‐15 constituent les intermédiaires permettant l'accès aux 2‐(1‐pyrrolyl) diazoacétophénones 16‐20 et aux acides phénylacétiques. Les spectres de rmn confirment la structure des dérivés obtenus.
Velocity estimation using tomographic migration velocity analysis (1995)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1995Velocity estimation using tomographic migration velocity analysisAuthors: Tamas NemethTamas NemethUniversity of Utahhttps://doi.org/10.1190/1.1887304 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1887304FiguresReferencesRelatedDetailsCited byAutomatic traveltime inversion via sparse decomposition of seismic dataBo Feng, Huazhong Wang, and Ru-Shan Wu23 October 2018 | GEOPHYSICS, Vol. 83, No. 6Data domain automatic reflection traveltime inversion via sparse decomposition of seismic dataBo Feng, Ru-Shan Wu, Huazhong Wang, Fei Luo, and Hui Li17 August 2017Determining migration velocity for the near surface using joint analysis of refractions and reflectionsDaniel Feigenbaum, Julian Ivanov, and Richard D. Miller17 August 2017CRP-based seismic migration velocity analysisWeihong Fei and George A. McMechan22 May 2006 | GEOPHYSICS, Vol. 71, No. 3Tau migration and velocity analysis: Theory and synthetic examplesTariq Alkhalifah4 August 2003 | GEOPHYSICS, Vol. 68, No. 4The Liberating Role of Conflict in Group Creativity: A Cross Cultural StudySSRN Electronic Journal, Vol. 68Fast velocity analysis by wavepath migration: A 2‐D field data exampleHongchuan Sun3 January 2005 SEG Technical Program Expanded Abstracts 1995ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1995 Pages: 1566 publication data© 1995 Copyright © 1995 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 10 Feb 2005 CITATION INFORMATION Tamas Nemeth, (1995), "Velocity estimation using tomographic migration velocity analysis," SEG Technical Program Expanded Abstracts : 1058-1061. https://doi.org/10.1190/1.1887304 Plain-Language Summary PDF DownloadLoading ...
Conflict Detection and Resolution for Future Air Transportation Management (1997)

With a Free Flight policy, the emphasis for air traffic control is shifting from active control to passive air traffic management with a policy of intervention by exception. Aircraft will be allowed to fly user preferred routes, as long as safety Alert Zones are not violated. If there is a potential conflict, two (or more) aircraft must be able to arrive at a solution for conflict resolution without controller intervention. Thus, decision aid tools are needed in Free Flight to detect and resolve conflicts, and several problems must be solved to develop such tools. In this report, we analyze and solve problems of proximity management, conflict detection, and conflict resolution under a Free Flight policy. For proximity management, we establish a system based on Delaunay Triangulations of aircraft at constant flight levels. Such a system provides a means for analyzing the neighbor relationships between aircraft and the nearby free space around air traffic which can be utilized later in conflict resolution. For conflict detection, we perform both 2-dimensional and 3-dimensional analyses based on the penetration of the Protected Airspace Zone. Both deterministic and non-deterministic analyses are performed. We investigate several types of conflict warnings including tactical warnings prior to penetrating the Protected Airspace Zone, methods based on the reachability overlap of both aircraft, and conflict probability maps to establish strategic Alert Zones around aircraft.
The molecular biology of chronic myeloid leukaemia. (1996)

Chronic myeloid leukaemia (CML) is characterized cytogenetically by a t(9;22)(q34;ql1) reciprocal translocation which gives origin to a hybrid BCR-ABL gene, encoding a p2lO(BCR-ABL) fusion protein with elevated tyrosine kinase activity and transforming abilities. The t(9;22) was suggested to be associated with genomic imprinting of centromeric regions of chromosomes 9 and 22, but the genes directly affected by the translocation, ABL and BCR, were shown not to be imprinted. For most diagnostic and research purposes the BCR-ABL gene can be efficiently identified by reverse-transcription and polymerase chain reaction (RT/PCR) amplification of its fusion transcripts, which can be quantified by competitive PCR and similar assays for assessment of residual disease in the follow-up of therapy. In the great majority of CML patients the BCR-ABL transcripts exhibit a b2a2 and/or a b3a2 junction; in rare cases, the only detectable BCR-ABL transcripts have unusual junctions, such as b2a3, b3a3, e1a2 or e6a2. There is a recent suggestion that the BCR-ABL gene may not be always 'functional', since extremely low levels of BCR-ABL transcripts can be found in leucocytes from normal individuals and, conversely, it appears that no BCR-ABL transcription can be detected in a proportion of Ph-positive haematopoietic progenitors from some CML patients. The role, if any, of the reciprocal ABL-BCR hybrid gene in CML is unknown. Although its mRNA message is in frame, no ABL-BCR fusion protein has yet been identified in CML patients. The blast crisis of CML has been variably associated with abnormalities of proto-oncogenes, such as RAS and MYC, or of tumour suppressor genes, in particular RB, p53 and p16, or with the generation of chimeric transcription factors, as in the AML1-EVI1 gene fusion. It is likely, therefore, that multiple and alternative molecular defects, as opposed to a single universal mechanism, underlie the acute transformation of the disease.
Conduction Cardiograph-Bundle of His Detector (1975)

Heart block is a potential complication in the surgical repair of several congenital cardiac defects. The proximity of the bundle of His to these defects makes their repair particularly hazardous. Earlier workers devised a method for the anatomic localization of portions of the conduction system at the time of cardiotomy. This method is inefficient and time-consuming and therefore has not received general acceptance. This paper describes an instrument which expands upon that method to facilitate and expedite the localization process. This should enhance the overall utility of the method. The instrument is self-contained, reduces the signal complexity arriving from the exploring probe, analyzes the waveforms and responds instantly with an audible tone when the probe overlies the bundle of His.
Expression Analysis of Human HL60 Cells Exposed to 60 Hz Square- or Sine-Wave Magnetic Fields (2000)

A total of 960 complementary DNA (cDNA) clones from an HL60 cell cDNA library were screened to discover genes that were differentially expressed in HL60 cells exposed to 60 Hz square-wave magnetic fields (MFs) compared to sham-exposed cells. Square-wave fields are rich in odd harmonic frequency content. We used a two-gel cDNA library screening method (BIGEL) to identify treatment-induced alterations in gene expression. Four cDNA clones were tentatively identified as differentially expressed after exposure to square-wave MFs at 2 mT for 24 h. BIGEL-identified genes (GenBank accession number) corresponding to these clones were: TI227H (D50525), EST Homo sapiens partial cDNA (Z17814), human ribosomal protein S13 (L01124), and AICAR transformylase mRNAs (D82348). The differences in mRNA levels were not confirmed in test compared to experimental cells by Northern analysis. In other experiments, we used concurrent exposure to 60 Hz sine- or square-wave MFs (0 or 2 mT, duration of 3 or 24 h, no postexposure delay). In addition to the four BIGEL genes, we also investigated MYC, HSP70, RAN and SOD1. In the case of MYC and HSP70, square-wave MFs appeared to exhibit more marked alterations when compared to sinusoidal waveforms, but the overall results indicated no effect of possible differential magnetic-field-induced expression of all eight genes. In contrast, alterations of mRNA levels were observed for seven genes after exposure to X irradiation, hyperthermia and TPA. These results are contrary to previously proposed similarities between the action of these agents and MF effects on gene transcription.
Model-based MTPA control of permanent magnet synchronous machine drives under one-phase open-circuit fault (2016)

This paper proposes a fault-tolerant MTPA control method for permanent magnet synchronous machine (PMSM) drives under one-phase open-circuit fault. The proposed method isolates the open-circuit faulted phase after the fault and the motor starts to operate as a two-phase machine fed by an H-bridge inverter. Neither an additional inverter leg nor a neutral-point access to stator or DC link is used for the speed control. This post-fault configuration enables the motor to operate in a wider range of speed even than the healthy system, despite the reduced power devices, drivers and current sensors. The behavior of the faulted system is analyzed with a modified d-q model. Based on the analytic results, a speed control algorithm is developed. The strategy includes a maximum torque per ampere (MTPA) control to improve the drive efficiency and a flux-weakening control to maximize the feasible inverter output voltage within the limit. The proposed control method is verified by experimental results.
Hybrid adaptive memory programming using GRASP and path relinking for the scheduling workover rigs for onshore oil production (2005)

There are many oil wells in onshore fields that need artificial lift methods in Brazil. These wells periodically need some maintenance services that are performed by workover rigs, available on a limited number. The problem consists in optimizing the workover rigs schedule by minimizing the production loss associated with the yield of the wells that are waiting for service. We propose a hybrid GRASP algorithm to solve this problem. Experimental results illustrate the effectiveness of the hybrid version in terms of quality solution.
Leukocyte Inflammatory Response in a Rat Urinary Bladder Regeneration Model Using Porcine Small Intestinal Submucosa Scaffold (2009)

Small intestinal submucosa (SIS) is a biodegradable scaffold that supports bladder regeneration after partial cystectomy. We sought to define the inflammatory response present in a rat bladder augmentation model using distal ileal SIS. Fifteen Sprague-Dawley rats underwent hemi-cystectomy followed by anastomosis of a bladder patch of SIS. Bladders were excised after days 2, 7, 14, 28, and 56. Tissue regeneration was evaluated by standard hematoxylin and eosin. Immunohistochemical staining was used to quantify neutrophils, macrophages, eosinophils, and mast cells. Total cell counts per unit area were compared between native and graft portions of the bladder for each cell type across the entire time course. Statistical analyses were conducted with the Wilcoxon Rank-Sum and Kruskal-Wallis tests. All tests were two-sided with significance set at p < 0.05. These inflammatory responses evolved consistently across all bladders over time. Neutrophil and eosinophil numbers were highest at day 2 and decreased over the 56-day period. In contrast, macrophage and mast cell numbers were low at days 2, 7, and 14; peaked at day 28; and decreased once again at day 56. Cell counts at native and graft sites were equivalent for all cell types, except neutrophils, which were more commonly found in the graft (124 vs. 24 cells/mm(2), p = 0.009). Thus, the inflammatory processes change over time during SIS-mediated bladder regeneration. Similar cell densities are present between the native and SIS portions of the bladder, but neutrophils predominate in the graft areas.
Novel Potent and Selective Central 5-HT<sub>3</sub> Receptor Ligands Provided with Different Intrinsic Efficacy. 1. Mapping the Central 5-HT<sub>3</sub> Receptor Binding Site by Arylpiperazine Derivatives (1998)

Synthesis and pharmacological evaluation of a series of condensed quinoline and pyridine derivatives bearing a N-methylpiperazine moiety attached to the 2-position of the quinoline or pyridine nucleus are described. 5-HT receptor binding studies revealed subnanomolar affinity for the 5-HT3 receptor subtype in some of the compounds under study. The most active compound (5b) displayed a Ki value about 1 order of magnitude higher than that of quipazine along with a higher selectivity. The potential 5-HT3 agonist/antagonist activity of four selected compounds was assessed in vitro on 5-HT3 receptor-dependent [14C]guanidinium uptake in NG 108-15 cells. Compound 5j acted as a 5-HT3 agonist in this assay with an EC50 value close to that reported for quipazine, while 5b was a partial agonist with an EC50 value of about 0.25 nM, and compound 5c possessed antagonist properties with an IC50 value (approximately 8 nM) in the same range as those of previously characterized 5-HT3 receptor antagonists. Qualitative and quantitative structure-affinity relationship studies carried out by making use of theoretical molecular descriptors allowed to elucidate the role of the main pharmacophoric components and to develop a model for the interaction of the 5-HT3 ligands related to quipazine with their receptor.