gebhart/patrepeval huggingface dataset:
Development of an electrochemical immunosensor for the detection of HbA1c in serum (2012)

An electrochemical immuno-biosensor for detecting glycosylated haemoglobin (HbA1c) is reported based on glassy carbon (GC) electrodes with a mixed layer of an oligo(phenylethynylene) molecular wire (MW) and an oligo(ethylene glycol) (OEG). The mixed layer is formed from in situ-generated aryl diazonium cations. To the distal end of the MW, a redox probe 1,1'-di(aminomethyl)ferrocene (FDMA) was attached followed by the covalent attachment of an epitope N-glycosylated pentapeptide (GPP), an analogon to HbA1c, to which an anti-HbA1c monocolonal antibody IgG can selectively bind. HbA1c was detected by a competitive inhibition assay based on the competition for binding to anti-HbA1c IgG antibodies between the analyte in solution, HbA1c, and the surface bound epitope GPP. Exposure of the GPP modified sensing interface to the mixture of anti-HbA1c IgG antibody and HbA1c results in the attenuation of ferrocene electrochemistry due to free antibody binding to the interface. Higher concentrations of analyte led to higher Faradaic currents as less anti-HbA1c IgG is available to bind to the electrode surface. It was observed that there is a good linear relationship between the relative Faradaic current of FDMA and the concentration of HbA1c from 4.5% to 15.1% of total haemoglobin in serum without the need for washing or rinsing steps.
A Posteriori Estimation of Correlated Jointly Gaussian Mean Vectors (1984)

This paper describes the use of maximum a posteriori probability (MAP) techniques to estimate the mean values of features used in statistical pattern classification problems, when these mean feature values from the various decision classes are jointly Gaussian random vectors that are correlated across the decision classes. A set of mathematical formalisms is proposed and used to derive closed-form expressions for the estimates of the class-conditional mean vectors, and for the covariance matrix of the errors of these estimates. Finally, the performance of these algorithms is described for the simple case of a two-class one-feature pattern recognition problem, and compared to the performance of classical estimators that do not exploit the class-to-class correlations of the features' mean values.
Curvature estimation for segmentation of triangulated surfaces (2003)

An important aspect of reverse engineering is the production of digital representations of physical objects for CAD systems. The first stage involves taking 3D coordinate measurements for points on the surface of the object and producing in general an unstructured set of points, called a point cloud. A triangulated surface can be generated from such a point cloud, allowing copies of the original object to be manufactured. However, these triangulated surfaces generally consist of a very large number of triangles with small errors in the positions of their vertices. In many cases the original object is made up of parts of a number of simple geometric objects. Our aim is to segment the triangulated surface into a small number of components, each of which approximates to part of a simple geometric shape. We have developed algorithms for curvature estimation in order to support a 'region growing' method of segmentation.
Sulfoxide-Mediated α-Arylation of Carbonyl Compounds (2011)

A novel sulfoxide-mediated α-arylation of carbonyl compounds is reported. This reaction proceeds under very mild conditions at room temperature and does not require any transition-metal promoter or catalyst.
Occlusion-adaptive 2-D mesh tracking (2002)

Available 2-D mesh models, whether uniform or adaptive, preserve neighboring relationships between the patches (connectivity) everywhere within the frame, which is clearly not suitable across motion and occlusion boundaries. To this effect, this paper proposes an occlusion-adaptive, content-based mesh design and forward tracking algorithm, where no node points are placed within the background to be covered (BTBC), and node points along the boundary of the uncovered background (UB) are allowed to split. Furthermore, the mesh is refined within the UB region at every frame. Experimental results show successful motion compensation and tracking.
Gas market development in Brazil - how gas-fueled power plants can operate in Brazil's hydro dominated system (1999)

This note discusses the issues faced in introducing new gas fired power generation plants into Brazil's hydropower dominated system. Ordinarily, power project developers seek to operate their plants at high load factor over the plant lifetime, to ensure financial viability. However, the year to year variation of rainfall in Brazil-which could result in a surplus of hydropower in some periods, and a shortfall in others-posed major questions concerning how the gas fired plants would operate. Recognizing that gas-fueled power generation could improve the financial viability of the Bolivia-Brazil pipeline, through the use of upside capacity, ELETROBRAS, in cooperation with the Bank, set out to analyze the economics of thermal generation-including gas, oil, and coal-operating within the hydro system. Introducing gas-fueled generation capacity in Brazil's south-southeast power system, is shown to be the optimum solution for a wide range of assumptions on fuel prices, and other economic parameters. Due to the large existing reservoir capacity, the production schedules of these plants can be predicted with enough confidence, to allow the development of a secondary market for gas. The contractual framework based on the priority fee as described in this paper, could be applied in other countries where there is an opportunity to develop gas-fueled power generation, within a hydro-dominated system.
Purification and characterization of roseotoxin B, a toxic cyclodepsipeptide from Trichothecium roseum (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPurification and characterization of roseotoxin B, a toxic cyclodepsipeptide from Trichothecium roseumGeorge W. Engstrom, John V. DeLance, John L. Richard, and Albert L. BaetzCite this: J. Agric. Food Chem. 1975, 23, 2, 244–253Publication Date (Print):March 1, 1975Publication History Published online1 May 2002Published inissue 1 March 1975https://doi.org/10.1021/jf60198a050Request reuse permissionsArticle Views227Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Get e-Alertsclose Get e-Alerts
The GANDALF 128-channel Time-to-Digital Converter (2013)

The GANDALF 6U-VME64x/VXS module has been developed to cope with a variety of readout tasks in nuclear physics experiments and is operated at the COMPASS-II experiment at CERN. Based on this module, a 128-channel Time-to-Digital Converter with a time resolution of 93 ps has been implemented successfully in a Xilinx Virtex-5 FPGA using a shifted clock sampling algorithm. Beyond that, the design was extended by adding scaler channels for simultaneous rate measurements.
Domain Decomposition for a linear advection-diffusion equation by means of minimax filtering (2014)

In this work a novel strategy that combines Domain Decomposition, Differential Algebraic Equations (DAE) and Minimax Estimation is created to contruct a numerical solution for a linear non stationary advection-diffusion equation. The proposed approach helps to control the error introduced by Domain Decomposition and FEM discretisation and allows to combine observations with solutions of the advection-diffusion equation.
Characterization of room temperature detectors using the proposed IEEE standard (2005)

The availability and quality of room temperature detectors such as cadmium-zinc-telluride (CZT) has improved in recent years. There are many applications for these, but at present there are inconsistencies among manufacturers and users in the methods of testing and describing them. To overcome this deficiency, a standard is being developed similar to the ones that apply to NaI, HPGe and other detectors. The standard will describe methods of measuring efficiency, resolution and noise, and will provide details of the test apparatus necessary to perform the tests. It will also take into account the differences between the newer semiconductor detectors and those developed earlier. It furnishes definitions for specialized terms. Tutorial material is included.
Dynamic analysis of seeds motion during the sucking process on vacuum precision seeder (2010)

The main concern of this paper was to establish the force model of seeds motion during the sucking process and to find different factors impacting seeds suction performance. Then the mathematical model of forces acting on seeds during the sucking process was established in order to optimize the working parameters including the sucking force F, the rotational speed of cylinder ω and the position angle of vibration seeds bed α. The results showed that the seeds suction performance would be improved with the increasing of α and F but decreased with the increasing of ω. Taking rape seeds as experimental material, seeds suction performance tests were conducted on the JPS-12 test-bed. The optimum parameters combined with the cylinder's rotational speed of 10rpm, the position angle of vibration seeds bed α of 30°, and the vacuum pressure of 2.5 kPa were received. The parameters were tested with the seeds single pickup ratio of 94.5%, the seeds missing pickup ratio of 1.8% and the seeds multiple pickup ratio of 3.7%.
Structure-Based Stabilization of an Enzyme: The Case of Penicillin Acylase from Alcaligenes faecalis (2005)

The modeled structure of penicillin acylase from Alcaligenes faecali (AFPGA) was constructed by comparative modeling with the Modeller program. Candidate positions that could be replaced with cysteine were estimated by scanning the modeled structure of AFPGA with the program MODIP (modeling disulfide bond in protein). The mutant Q3C/P751C had a higher optimum temperature by three degrees than that of the wild type AFPGA. The half life of the double mutant Q3C/P751C at 55 degrees C was increased by 50%. To our knowledge, this was the first structure-based genetic modification of AFPGA.
Synchronized multi-character motion editing (2009)

The ability to interactively edit human motion data is essential for character animation. We present a novel motion editing technique that allows the user to manipulate synchronized multiple character motions interactively. Our Laplacian motion editing method formulates the interaction among multiple characters as a collection of linear constraints and enforces the constraints, while the user directly manipulates the motion of characters in both spatial and temporal domains. Various types of manipulation handles are provided to specify absolute/relative spatial location, direction, time, duration, and synchronization of multiple characters. The capability of non-sequential discrete editing is incorporated into our motion editing interfaces, so continuous and discrete editing is performed simultaneously and seamlessly. We demonstrate that the synchronized multiple character motions are synthesized and manipulated at interactive rates using spatiotemporal constraints.
Pressurized melt growth of ZnO boules (2005)

Single crystal zinc oxide is a wide band gap semiconductor with great potential for a variety of commercial applications including substrates, UV photodetectors, acoustic wave devices, light emitting diodes, laser diodes, and high frequency electronic devices. ZnO is unique in that it has a very high exciton binding energy (60 meV) enabling stability at higher device operating temperatures, and it is highly resistant to radiation damage compared even to GaN. Bulk growth of ZnO single crystals is being conducted using the following primary methods: hydrothermal solution growth, seeded sublimation growth, and pressurized melt growth. Cermet, Inc. has employed the pressurized melt growth approach with much success. ZnO dissociates upon heating into a defective ZnO1−x structure, which is addressed by providing an overpressure of oxygen in the growth environment. Single crystals nucleate and grow from the stoichiometric ZnO melt, which is contained in a thin layer of cooled, polycrystalline ZnO, eliminating crucible-introduced impurities. From these large ingots, high quality (~104 defects cm−2, linewidths as low as 49 arcsec), high purity ZnO crystals have been crystallized, oriented, and shaped into round or square boules and eventually processed into epitaxial-ready substrates. The pressurized melt growth approach is highly scalable and can accommodate high growth rates (up to 1 cm h−1), which are two criteria that are appealing to industrial productioin of high quality substrates.
Exploring Individual Modernity in Sumatra (1989)

This article reports on afield research project involving the collection of data on social change and modernization among the Karo of Sumatra, Indonesia. The survey instrument included 113 variables, an Overall Modernization Index (as developed by Dr Alex Inkeles), an Animism Index, and five other indices. The study sought to determine dimensions of the survival of tradition as well as other aspects of changes in belief attitudes, behaviour, and social participation. A full random sample of adults was selected from twenty-one sites divided between highland, lowland, and urban settlements. The data reveals complex patterns of change with a tendency for traditional identities and social bonds to become stronger among those who are becoming more modern in matters of attitude, belief, education, and occupation. Yet, the range of variation is such that the data could not support most heuristic theories commonly used to explain individual behaviour and social change patterns in Third World countries.
Diurnal variation of cytosolic fatty acid-binding protein content and of palmitate oxidation in rat liver and heart. (1984)

Delipidated proteins from albumin-free liver and heart cytosol obtained from rats sacrificed at the mid-dark or the mid-light phase of the light cycle were assayed for their palmitate-binding capacity. In both tissues a marked variation of this binding capacity was observed from about 3-4 nmol/mg of protein in the mid-light phase of the cycle to about 7-8 nmol/mg of protein in the mid-dark phase. Sephadex G-75 chromatography of the cytosolic proteins revealed that the palmitate binding could in all cases almost entirely be attributed to proteins of Mr = 12,000-14,000, suggesting that the observed diurnal variations are related to differences in the content of fatty acid-binding protein (FABP). In both rat liver and heart FABP represents about 4 (mid-light) to 8% (mid-dark) of the total soluble proteins. Cholestyramine feeding increased the FABP content of liver cytosol from rats sacrificed at the mid-light phase, but not in those sacrificed at the mid-dark phase, in such a way that the diurnal variation of the FABP content virtually disappeared. The palmitate oxidation capacity and citrate synthase activity also exhibited a concomitant diurnal periodicity in rat liver and, to a lesser extent, in rat heart. The results provide additional evidence for an important role of FABP in cellular fatty acid metabolism in both liver and heart and for the similarity of FABP with sterol carrier protein.
A dynamic channel assignment scheme with two thresholds for load balancing in cellular networks (2003)

A channel assignment problem is to develop efficient channel assignment schemes that can maximize the number of calls served in cellular network systems. This problem is one of the most important problems in the design and operation of cellular networks. But the non-uniformity of demand (or traffic) in different cells may lead to a gross imbalance in the system performance. So, the system should be able to cope with such traffic overheads in certain cells. Previous schemes with one threshold have a redundant channel borrowing problem. However, in our scheme, the problem of such redundant channel borrowing and imbalance in the system performance is solved using two thresholds.
Design, implementation and evaluation of a novel public display for pedestrian navigation (2009)

Important drawbacks of map-based navigation applications for mobile phones are their small screen size and that users have to associate the information provided by the mobile phone with the real word. Therefore, we designed, implemented and evaluated the Rotating Compass - a novel public display for pedestrian navigation. Here, a floor display continuously shows different directions (in a clockwise order) and the mobile phone informs the user when their desired direction is indicated. To inform the user, the mobile phone vibrates in synchronization with the indicated direction. We report an outdoor study that compares a conventional paper map, a navigation application running on a mobile device, navigation information provided by a public display, and the Rotating Compass. The results provide clear evidence of the advantages of the new interaction technique when considering task completion time, context switches, disorientation events, usability satisfaction, workload and multi-user support.
Phosphodiesterase 3A binds to 14-3-3 proteins in response to PMA-induced phosphorylation of Ser428 (2005)

PDE3A (phosphodiesterase 3A) was identified as a phosphoprotein that co-immunoprecipitates with endogenous 14-3-3 proteins from HeLa cell extracts, and binds directly to 14-3-3 proteins in a phosphorylation-dependent manner. Among cellular stimuli tested, PMA promoted maximal binding of PDE3A to 14-3-3 proteins. While p42/p44 MAPK (mitogen-activated protein kinase), SAPK2 (stress-activated protein kinase 2)/p38 and PKC (protein kinase C) were all activated by PMA in HeLa cells, the PMA-induced binding of PDE3A to 14-3-3 proteins was inhibited by the non-specific PKC inhibitors Ro 318220 and H-7, but not by PD 184352, which inhibits MAPK activation, nor by SB 203580 and BIRB0796, which inhibit SAPK2 activation. Binding of PDE3A to 14-3-3 proteins was also blocked by the DNA replication inhibitors aphidicolin and mimosine, but the PDE3A-14-3-3 interaction was not cell-cycle-regulated. PDE3A isolated from cells was able to bind to 14-3-3 proteins after in vitro phosphorylation with PKC isoforms. Using MS/MS of IMAC (immobilized metal ion affinity chromatography)-enriched tryptic phosphopeptides and phosphospecific antibodies, at least five sites on PDE3A were found to be phosphorylated in vivo, of which Ser428 was selectively phosphorylated in response to PMA and dephosphorylated in cells treated with aphidicolin and mimosine. Phosphorylation of Ser428 therefore correlated with 14-3-3 binding to PDE3A. Ser312 of PDE3A was phosphorylated in an H-89-sensitive response to forskolin, indicative of phosphorylation by PKA (cAMP-dependent protein kinase), but phosphorylation at this site did not stimulate 14-3-3 binding. Thus 14-3-3 proteins can discriminate between sites in a region of multisite phosphorylation on PDE3A. An additional observation was that the cytoskeletal cross-linker protein plectin-1 coimmunoprecipitated with PDE3A independently of 14-3-3 binding.
Phagocytic and Chemotactic Function of Polymorphonuclear and Mononuclear Leucocytes in Patients with Recurrent Staphylococcal Infections (1980)

From 21 patients with chronic or recurrent staphylococcal infections, phagocytosis and intracellular killing of Staphylococcus aureus by polymorphonuclear (PMN) and mononuclear (MN) leucocytes were evaluated. Also chemotactic responsiveness and the capacity of their sera to opsonize Staph. aureus was tested. The chemotactic, phagocytic and bactericidal capacity of PMN's and MN's from patients was significantly decreased. The mean uptake of Staph. aureus by patient PMN's and MN's was 65% and 44%, respectively, as compared to 85% and 75% observed with PMN's and MN's from 38 healthy donors. The phagocytic activity of 17/21 patients (81%) was below the normal range. A decreased chemotactic mobility and bactericidal capacity of patient leukocytes was also found and was always accompanied by a decreased rate of ingestion. Although a great variability was noted in the phagocytic capacity of leucocytes from patients tested repeatedly over periods up to 82 weeks, the mean value for phagocytosis remained below the normal range in 10/11 patients included in the follow-up study. Except for 1 patient with dysgammaglobulinemia, sera from the patients contained normal amounts of immunoglobulins and complement (CH50 and C3), and they all effectively opsonized Staph. aureus. The results indicate that defects in leucocyte function may be frequently involved in the pathogenesis of recurrent Staph. aureus infections.
SOAPdenovo2: an empirically improved memory-efficient short-read <i>de novo</i> assembler (2012)

Benchmark using the Assemblathon1 and GAGE datasets showed that SOAPdenovo2 greatly surpasses its predecessor SOAPdenovo and is competitive to other assemblers on both assembly length and accuracy. We also provide an updated assembly version of the 2008 Asian (YH) genome using SOAPdenovo2. Here, the contig and scaffold N50 of the YH genome were ~20.9 kbp and ~22 Mbp, respectively, which is 3-fold and 50-fold longer than the first published version. The genome coverage increased from 81.16% to 93.91%, and memory consumption was ~2/3 lower during the point of largest memory consumption.
未来自我连续性及其对个体心理和行为的影响 (2018)

<p id=C2>Future self-continuity refers to the degree of perceived connectedness between one’s present self and future self. A large body of research has demonstrated the significant role of future self-continuity in influencing temporal decision making, saving and consuming behaviors, academic achievements, social behaviors and exercise behavior. Future research may examine the neural basis of future self-continuity, explore its factors, and expand its potential applications.
Discovery of Anticancer Clinical Candidate, Tosedostat, As an Analgesic Agent (2019)

Tosedostat is an inhibitor of aminopeptidases currently in phase II clinical trials for the treatment of blood-related cancers. In our laboratories, we have discovered that it possesses analgesic properties. Extensive <i>in vivo</i> pharmacological studies for the determination of antinociceptive effects of tosedostat are presented here. These studies have indicated that the observed analgesic effect of tosedostat stems from its action on the peripheral nervous system with minimal contribution from the central nervous system. Additionally, when given in combination with morphine, tosedostat exerts a synergistic analgesic effect resulting in a reduction of effective dosages required to achieve the same analgesic effect. With broad implications in addressing the opioid addiction crisis, these revelations attest to tosedostat being a highly valuable drug candidate with diverse pharmacological functions.
1580 nm band all-optical ADM node prototype equipped with past automatic level control (2002)

A 1580 nm band all-optical ADM mode consisting of automatic gain-controlled optical pre- and post- amplifiers, add/drop multiplexing filters, optical switches, and channel-by-channel level equalizers is developed. The prototype node has a wide input dynamic range and good stability against fast input power transitions.