gebhart/patrepeval huggingface dataset:
Extended Release (2005)

To describe a challenging clinical entity that should be considered in patients presenting with drug overdose and recurrent symptoms, and to provide a discussion of the approach to endoscopic therapy. Medline search using various combinations of the following term(s): “bezoar,”“medication,”“pharmacobezoar,”“endoscopy,”“nifedipine.” Additionally, a review of the references in the citations provided by this search was performed. A 61 year-old female presented to the emergency department with a drug overdose of extended-release nifedipine and venlafaxine. In the emergency department she was treated with activated charcoal, calcium chloride and sodium bicarbonate. She exhibited bradycardia, hypotension, respiratory failure and was subsequently intubated. Within the initial 24 hours, the patient became hemodynamically stable, was extubated, and was transferred to the floor. Approximately 12 hours later, the patient became hypotensive and unresponsive, requiring transfer back to the intensive care unit. A cystic lesion was seen in the abdomen on a radiograph of the abdomen. Because of concern for a medication bezoar, an upper endoscopy was performed. On endoscopy a mass containing extended-release nifedipine tablets, venlafaxine granules and charcoal was seen in the fundus. An overtube was placed, and the bezoar was fragmented using a large snare. The pills were then removed using a Roth® retrieval net (US Endoscopy, Mentor, OH.) In total 167 extended-release nifedipine tablets were removed. Unfortunately, the patient expired 72 hours later due to multisystem organ failure related to hypotension. There have been nine previous reports of medication bezoars composed of extended-release nifedipine preparations (Procardia XL®, Adalat XL®, nifedipine gastrointestinal system). None of the prior cases described ongoing or recurrent symptoms related to the active medication. This is the first known report of the endoscopic removal of a bezoar containing an antihypertensive medication in a symptomatic patient. A medication bezoar should be considered in any patient with recurrent symptoms following a drug overdose. Endoscopic removal is the treatment of choice for symptomatic bezoars.
Surface Tension-Dependent Surfactant Toxicity on the Green Peach Aphid, Myzus persicae (SULZER) (Hemiptera: Aphididae) (1994)

Toxicity of 32 surfactants on the green peach aphid, Myzus persicae, were observed at a concentration of 0.1% in order to determine the mechanism of surfactant action. Eight of the surfactants, of various chemical structures, exhibited high toxicities, those eight being two polyoxyethylene alkylethers, one sorbitan fatty acid ester, two octylphenoxypolyethoxyethanols, two dimethyl siloxane derivatives, and one fatty acid salt. Other surfactants with common partial structures to these toxic ones were largely ineffective. And what is more, there were no surfactant-dependent differences in the appearance of the dead aphids-paralyses occurred within hours, the dead aphids attached to leaves by their inserted stylets-suggesting a common physical basis to the toxicity phenomenon irrespective of chemical structure. A close connection between toxicity and surface tension was thereby uncovered, leading to the conclusion that toxicity might be related to aphid suffocation in the highly wettable surfactant solutions.
Determination of Cell Permeabilization and Beta-Galactosidase Extraction from <i>Aspergillus oryzae</i> CCT 0977 Grown in Cheese Whey (2018)

Aspergillus oryzae grown in cheese whey has the ability to produce beta-galactosidase. The objective of this work was to define the parameters for the determination of cell permeabilization and extraction of the enzyme from Aspergillus oryzae CCT 0977 biomass, with high enzymatic activity. The Box–Behnken design was used to determine cell permeabilization and extraction of beta-galactosidase conditions. The fermentation was carried out for a period of 5 days at 28°C, having as substrate the deproteinized cheese whey. To determine the effect of the variables on beta-galactosidase activity, enzymatic activity was determined by the lactose hydrolysis reaction. The most efficient condition for cell permeabilization was 25% ethanol at 30°C for 90 min, obtaining an enzymatic activity of 0.44 U·mL −1 . For beta-galactosidase extraction from the biomass, the most efficient condition was 5.3% chloroform at 48°C, with an enzymatic activity of 0.17 U·mL −1 . The use of ethanol was most efficient to promote cell permeability of Aspergillus oryzae CCT 0977.
Efficiency of Biometric integration with Salt Value at an Enterprise Level and Data Centres (2011)

This chapter is going to deal with enhancing the efficiency of Biometric by
integrating it with Salt Value (randomly generated value of varying length).
Normally at an enterprise level or data centres, the servers are maintained
with complex passwords and they are known only to the system administrators.
Even after applying lot of securities at an expert level, the hackers are able
to penetrate through the network and break the passwords easily. Here how the
biometric can play a vital role and that too with the inclusion of Salt value
can prevent the hacker from stealing the confidential data's of an
organization.
Evaluation of cilofungin, a lipopeptide antifungal agent, in vitro against fungi isolated from clinical specimens (1989)

Cilofungin (LY121019) is a new lipopeptide antifungal drug. We tested this drug against 141 pathogenic fungal isolates. All fungal species were tested by broth dilution at 35 degrees C. Malassezia furfur was tested by agar dilution. The results demonstrate the specificity of cilofungin activity. Candida albicans, Candida tropicalis, and Malassezia pachydermatis were highly susceptible, whereas Candida parapsilosis, Candida pseudotropicalis, Candida krusei, Torulopsis glabrata, Blastomyces dermatitidis, Cryptococcus neoformans, Aspergillus species, M. furfur, and Paracoccidioides brasiliensis were more resistant.
Practical Approximate Solutions to Linear Operator Equations When the Data are Noisy (1977)

We consider approximate solutions $f_{n,\lambda } $ to linear operator equations $\mathcal{K}f = g$, of the form: $f_{n,\lambda } $ is the minimizer in $\mathcal{H}$ of $({1 / n})\sum _{j = 1}^n {[(\mathcal{K}h)(t_j ) - y(t_j )]} ^2 + \lambda \| h \|^2 $, where $\mathcal{H}$ is a Hilbert space, and the data $\{ {y(t_j )} \}$ satisfy $y(t_j ) = g(t_j ) + \varepsilon (t_j )$, the $\{ {\varepsilon (t_j )} \}$ being measurement errors. $f_{n,\lambda } $ is the so-called regularized solution, and $\lambda > 0$ is the regularization parameter, to be chosen. It is important to choose $\lambda $ correctly. The purpose of this paper is to propose the method of weighted cross-validation for choosing $\lambda $from the data. We suppose that g is very smooth and the errors are white noise. It is shown that the weighted cross-validation estimate $\hat \lambda $ estimates the value of $\lambda $ which minimizes $({1 / n})E\sum\nolimits_{j = 1}^n {[(\mathcal{K}f_{n,\lambda } )(t_j ) - (\mathcal{K}f)(t_j )]} ^2 $ . Results related to the convergence of $\| {f - f_{n,\hat \lambda } } \|$, including rates, are obtained.
Identification of <i>N</i>-(2-Phenoxyethyl)imidazo[1,2-<i>a</i>]pyridine-3-carboxamides as New Antituberculosis Agents (2016)

A series of imidazo[1,2-<i>a</i>]pyridine carboxamides (IPAs) bearing an <i>N</i>-(2-phenoxyethyl) moiety was designed and synthesized as new antitubercular agents. Seven 2,6-dimethyl IPAs demonstrated excellent <i>in vitro</i> activity (MIC: 0.025-0.054 μg/mL) against the drug susceptive H37Rv strain and two clinically isolated multidrug-resistant <i>Mycobacterium tuberculosis</i>strains. Compound <b>10j</b> displayed acceptable safety and pharmacokinetic properties, opening a new direction for further development.
Wheat Callus Culture: the Initiation, Growth and Organogenesis of Callus Derived from Various Explant Sources (1978)

Callus was obtained from mature excised embryos of wheat, from nodal and internodal stem segments and from rachis segments using the medium of Murashige and Skoog(1962)(M medium), containing 1-0mg l −1 2,4-D, and from immature embryos using the medium of Green and Phillips (1975) containing 2 mg l −1 2,4-D. Callus yield from mature embryos depended upon the cultivar used. No callus could be obtained from leaf segments. Callus derived from mature embryos and nodal stem segments was successfully maintained by serial sub-culture on the M medium containing 2,4-D for up to 3 years although its growth rate declined to a lower level as culture proceeded. Such cultures consistently produced roots when transferred to a medium containing a low level of 2,4-D or no 2,4-D. The presence of the auxin was essential for continued proliferation of the callus tissue. Shoot initiation was infrequent, did not occur after the first few sub-cultures and could not be enhanced by various auxin and cytokinin additions to the medium. Callus derived from immature embryos did not have an enhanced potential for shoot initiation.
An Automated System for Collection and Counting of Parasitized Leafminer (Diptera: Agromyzidae) Larvae (1996)

F. L. Petitt, D. S. Shuman, D. O. Wietlisbach, J. A. Coffelt, An Automated System for Collection and Counting of Parasitized Leafminer (Diptera: Agromyzidae) Larvae, The Florida Entomologist, Vol. 79, No. 3 (Sep., 1996), pp. 450-454
Structure determination of a novel cyclic phosphocompound isolated from <i>Desulfovibrio desulfuricans</i> (1992)

The structure of a novel diphosphodiester compound recently detected in Desulfovibrio desulfuricans cells [Santos, Fareleira, Pedregal, LeGall & Xavier (1991) Eur. J. Biochem. 201, 283-287] was fully elucidated using a combination of n.m.r. techniques in aqueous and in methanolic solutions. The novel metabolite was identified as 3-methyl-1,2,3,4-tetrahydroxybutane-1,3-cyclic bisphosphate, and the minimum energy conformation is presented. The two chiral centres have the relative configuration RS.
Morphology engineering of ZnO nanostructures for high performance supercapacitors: enhanced electrochemistry of ZnO nanocones compared to ZnO nanowires (2017)

In this work, the morphology of ZnO nanostructures is engineered to demonstrate enhanced supercapacitor characteristics of ZnO nanocones (NCs) compared to ZnO nanowires (NWs). ZnO NCs are obtained by chemically etching ZnO NWs. Electrochemical characteristics of ZnO NCs and NWs are extensively investigated to demonstrate morphology dependent capacitive performance of one dimensional ZnO nanostructures. Cyclic voltammetry measurements on these two kinds of electrodes in a three-electrode cell confirms that ZnO NCs exhibit a high specific capacitance of 378.5 F g<sup>-1</sup> at a scan rate of 20 mV s<sup>-1</sup>, which is almost twice that of ZnO NWs (191.5 F g<sup>-1</sup>). The charge-discharge and electrochemical impedance spectroscopy measurements also clearly result in enhanced capacitive performance of NCs as evidenced by higher specific capacitances and lower internal resistance. Asymmetric supercapacitors are fabricated using activated carbon (AC) as the negative electrode and ZnO NWs and NCs as positive electrodes. The ZnO NC⫽AC can deliver a maximum specific capacitance of 126 F g<sup>-1</sup> at a current density of 1.33 A g<sup>-1</sup> with an energy density of 25.2 W h kg<sup>-1</sup> at the power density of 896.44 W kg<sup>-1</sup>. In contrast, ZnO NW⫽AC displays 63% of the capacitance obtained from the ZnO NC⫽AC supercapacitor. The enhanced performance of NCs is attributed to the higher surface area of ZnO nanostructures after the morphology is altered from NWs to NCs.
A model of gastric emptying in cats shows solid emptying is promoted by MK-329: a CCK antagonist. (1990)

The effect of MK-329, a potent, orally active, nonpeptidal cholecystokinin (CCK) antagonist, was measured on the gastric emptying rate of a solid meal in cats. External scintigraphy of cats that had been fed a meal of technetium-99m-(99mTc) labeled rabbit liver and light cream allowed the measurement of the emptying rates of either the liquid or solid portion of a meal under physiologic conditions. In cats, liquids emptied 2.6 times faster than solids [163 +/- 11 min vs. 62 +/- 3 min (mean +/- s.e.)]. At 3 or 10 mg/kg p.o., MK-329 gastric emptying was significantly accelerated, with the mean half-time of emptying being decreased by 34 +/- 11% (mean +/- s.e.) of the control half-times (p less than 0.02). Using only responders (five of six animals), mean half-time was decreased by 55 +/- 4% of the control half-times. CCK is important in regulating the emptying of solid food from the stomach because the CCK antagonist MK-329 accelerates that emptying.
Benzo[k, <i>l</i>], xanthene–3, 4–dicarboximides and benzimidazoxanthenoisoquinolinones – yellow and orange dyes for synthetic–polymer fibres (1989)

Condensation of 4–chloro–l, 8–naphthalic anhydride with 2–nitrophenol afforded 4–(2–nitrophenoxy)–l, 8–naphthalic anhydride, which on reduction followed by Pschorr intramolecular cyclisation gave benzo[k, l]xanthene–3, 4–dicarboxylic acid anhydride. The identity of the product was confirmed by its alternative synthesis from 5–amino–4–phenoxy–l, 8–naphthalic anhydride. Benzo[k, l]xanthene–3, 4–dicarbox–ylic acid anhydride condensed with alkylamines or arylamines and with o–phenylenediamines to yield the corresponding imides and imidazole derivatives, which coloured polyester in fluorescent greenish–yellow to orange hues, respectively, of good fastness to light and sublimation. The colour of the dyes is discussed with respect to analogous ring–closed sulphur– containing heterocycles.
Effects of nanoporous anodic titanium oxide on human adipose derived stem cells (2016)

The aim of current bone biomaterials research is to design implants that induce controlled, guided, successful, and rapid healing. Titanium implants are widely used in dental, orthopedic, and reconstructive surgery. A series of studies has indicated that cells can respond not only to the chemical properties of the biomaterial, but also, in particular, to the changes in surface topography. Nanoporous materials remain in focus of scientific queries due to their exclusive properties and broad applications. One such material is nanostructured titanium oxide with highly ordered, mutually perpendicular nanopores. Nanoporous anodic titanium dioxide (TiO<sub>2</sub>) films were fabricated by a three-step anodization process in propan-1,2,3-triol-based electrolyte containing fluoride ions. Adipose-derived stem cells offer many interesting opportunities for regenerative medicine. The important goal of tissue engineering is to direct stem cell differentiation into a desired cell lineage. The influence of nanoporous TiO<sub>2</sub> with pore diameters of 80 and 108 nm on cell response, growth, viability, and ability to differentiate into osteoblastic lineage of human adipose-derived progenitors was explored. Cells were harvested from the subcutaneous abdominal fat tissue by a simple, minimally invasive, and inexpensive method. Our results indicate that anodic nanostructured TiO<sub>2</sub> is a safe and nontoxic biomaterial. In vitro studies demonstrated that the nanotopography induced and enhanced osteodifferentiation of human adipose-derived stem cells from the abdominal subcutaneous fat tissue.
End-Group Telechelic Oligo- and Polythiophenes by “Click” Reactions: Synthesis and Analysis via LC-ESI-TOF MS (2010)

End-group-modified poly(3-hexylthiophenes) (P3HT) with complex hydrogen-bonding moieties have been prepared starting from telechelic alkyne-functionalized P3HT via a copper(I) catalyzed azide/alkyne “click” reaction. The final polymers are projected to arrange into pseudoblock copolymers consisting of alternating donor/acceptor polymers for application in solar cell materials. Starting from a bromine-telechelic P3HT (Mn = 2000 g/mol; Mw/Mn = 1.2) prepared via the McCullough method followed by additional bromination reaction yielding telechelic P3HTs with (80% Br/Br; 20% H/Br) end groups, the respective α,ω-(trimethylsilyl)ethynyl-P3HTs were prepared via Sonogashira coupling reactions. Analysis of the end groups of the alkynyl-telechelic P3HT species was achieved by use of LC-ESI-TOF methods for the first time, proving the formation of ∼59% (ethynyl/ethynyl) and ∼40% (ethynyl/H) species within the α,ω-(trimethylsilyl)ethynyl-P3HTs, with only minor amounts (∼1%) of the respective (H/H)-modified species. Additionally, MALDI methods were used for a qualitative assessment. Subsequent azide/alkyne “click” reaction with either 1-(6-azidohexyl)thymine or 5-((4-azidobenzoyl)amino)-N,N′-(6-(octanoylamino)pyridin-2-yl)isophthalamide using CuI, CuBr(PPh3)3, or CuI·P(OEt)3 as catalyst yielded the final products with attached hydrogen bonds as judged by LC-ESI-TOF methods. The described method opens an access toward supramolecular P3HT polymers with hydrogen-bonding moieties.
Laser‐Reduced Graphene: Synthesis, Properties, and Applications (2018)

Abstract Laser reduction of graphene oxide has attracted significant interest in recent years, because it offers a highly flexible, rapid, and chemical‐free graphene fabrication route that can directly write on almost any solid substrate with down to sub‐micrometer feature size. Laser‐reduced graphene (LRG) is explored for various important applications such as supercapacitors, sensors, field effect transistors, holograms, solar cells, flat lenses, bolometers, thermal sound sources, cancer treatment, water purification, lithium‐ion batteries, and electrothermal heaters. This contribution reviews most recent research progress on the aspects of fabrication, properties, and applications of LRG. Particular attention is paid to the mechanism of LRG formation, which is still debatable. The three main theories, including the photochemical process, the photothermal process, and a combination of both processes, are discussed. Strategies for tuning the properties and performance of LRG, such as the laser parameters, chemical doping, structure modulation, and environment control, are highlighted. LRGs with better performance including smaller feature size, higher conductivity, and more flexible morphology design in both 2D and 3D formats will offer tremendous opportunities for advancement in electronics, photonic, and optoelectronic applications.
Activity of LY333328 Combined with Gentamicin In Vitro and in Rabbit Experimental Endocarditis Due to Vancomycin-Susceptible or -Resistant <i>Enterococcus faecalis</i> (2000)

We investigated the activity of LY333328 alone and combined with gentamicin, both in vitro and in a rabbit model of experimental endocarditis, against the susceptible strain Enterococcus faecalis JH2-2 and its two glycopeptide-resistant transconjugants, BM4316 (VanA) and BM4275 (VanB). MICs of LY333328 and gentamicin were 2 and 16 microgram/ml, respectively, for the three strains. In vitro, LY333328 alone was bactericidal at 24 h against JH2-2 at a concentration of 2 microgram/ml and against BM4316 and BM4275 at a concentration of 30 microgram/ml. The combination of LY333328 and gentamicin (4 microgram/ml) was synergistic and bactericidal after 24 h of incubation against the three strains at LY333328 concentrations of 2 microgram/ml for JH2-2 and 8 microgram/ml for BM4275 and BM4316. The combination of LY333328 and gentamicin was the only regimen demonstrating in vitro bactericidal activity against BM4316. In vivo, intravenous treatment with LY333328 alone, providing peak and trough serum levels of 83.3 +/- 1.3 and 3.8 +/- 0.2 microgram/ml, respectively, was inactive against BM4316 and BM4275 and selected mutants resistant to LY333328 in half of the rabbits infected with the VanA-type strain (MICs, 8 to 20 microgram/ml). However, the LY333328-gentamicin combination was active against the three strains and prevented the emergence of mutants resistant to both components of the combination. We conclude that the LY333328-gentamicin combination might be of interest for the treatment of enterococcal infections, particularly against VanA-type strains.
Endocrine and Immune Responses to Stress in Chronic Inflammatory Skin Disorders (2003)

Atopy is a genetically and environmentally determined condition predisposing to different forms such as atopic dermatitis (AD) or allergic asthma (AA). Both AD and AA are considered to be multifactorial diseases; however, distinct immunologic abnormalities have been described that play a crucial role. There is growing evidence that immunoglobulin-E hypersecretion and activation of the predominantly T-helper-2 (TH2)-like T cell subset trigger allergic inflammatory processes and cause the disease to become chronic. In the present paper, data suggesting reduced hypothalamic-pituitary-adrenal (HPA) axis responsiveness in patients with AD and AA are summarized, and the potential etiologic significance of a hyporeactive HPA axis is discussed. We propose that because of defective HPA axis, immunoregulation under stressful conditions is ineffective in patients with atopic conditions, leading to aberrant immune responses and subsequent exacerbation of the disease. Further research into the role of the HPA axis in atopy may elucidate the cause of stress-induced exacerbation of atopic symptoms and may be of clinical relevance.
Adaptive scheme for elimination of broadband noise and impulsive disturbances from AR and ARMA signals (1996)

The problem of elimination of measurement noise and impulsive disturbances from autoregressive and autoregressive moving average signals is considered. It is shown that the task of simultaneous detection/tracking/restoration can be stated as a nonlinear filtering problem and solved using the theory of extended Kalman filter. Numerical tests carried out for real audio signals corrupted by both real and artificially generated disturbances confirm very good properties of the proposed algorithm.
Saturated Ni-like Ag x-ray laser at 13.9 nm pumped by a single picosecond laser pulse (2003)

A demonstration of a transient collisional x-ray laser pumped by only a single profiled picosecond laser pulse is reported. Saturated operation on the $4d\ensuremath{-}4p$ transition in Ni-like silver at 13.9 nm is demonstrated using a pump energy of less than 3 J, i.e., more than halved in comparison to the best achievements in the double-pulse scheme. The pump laser pulse characteristics, traveling excitation wave, and x-ray output are discussed as well.