gebhart/patrepeval huggingface dataset:
Migrating to Cloud-Native Architectures Using Microservices: An Experience Report (2015)

Migration to the cloud has been a popular topic in industry and academia in recent years. Despite many benefits that the cloud presents, such as high availability and scalability, most of the on-premise application architectures are not ready to fully exploit the benefits of this environment, and adapting them to this environment is a non-trivial task. Microservices have appeared recently as novel architectural styles that are native to the cloud. These cloud-native architectures can facilitate migrating on-premise architectures to fully benefit from the cloud environments because non-functional attributes, like scalability, are inherent in this style. The existing approaches on cloud migration does not mostly consider cloud-native architectures as their first-class citizens. As a result, the final product may not meet its primary drivers for migration. In this paper, we intend to report our experience and lessons learned in an ongoing project on migrating a monolithic on-premise software architecture to microservices. We concluded that microservices is not a one-fit-all solution as it introduces new complexities to the system, and many factors, such as distribution complexities, should be considered before adopting this style. However, if adopted in a context that needs high flexibility in terms of scalability and availability, it can deliver its promised benefits.
A 16-kilodalton lipoprotein of the outer membrane of Serpulina (Treponema) hyodysenteriae (1992)

Serpulina (Treponema) hyodysenteriae P18A and VS1 were extracted by using the detergent Triton X-114 and separated into detergent and aqueous phases. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis and Western immunoblot analysis confirmed that a membrane-associated 16-kDa antigen was hydrophobic, since it was found in the detergent phase. A 45-kDa antigen partitioned into the aqueous phase, suggesting that it was hydrophilic and may be of periplasmic origin. When spirochetes were grown in the presence of [3H]palmitic acid, a predominant 16-kDa antigen was labeled; from the results of immunoprecipitation experiments, this antigen appeared to be the same as that recognized by both polyclonal and monoclonal antisera to a previously described 16-kDa antigen. This antigen was proteinase K sensitive and was not a component of the lipopolysaccharide, which, although [3H]palmitate labeled, was resistant to proteinase K digestion. The most probable explanation is that the 16-kDa antigen is a membrane-associated, surface-exposed, immunodominant lipoprotein.
Sensors: Glass Fibers with Carbon Nanotube Networks as Multifunctional Sensors (Adv. Funct. Mater. 12/2010) (2010)

A semiconductive interphase between a glass fi ber and an epoxy matrix is achieved by coating carbon nanotubes on the glass fiber, as reported by S.-L. Gao, E. Mäder, et al. on page 1885. The interphase at the nanoscale provides multifunctional sensibility, which can be observed by electric force microscopy. The resulting composites with an ultra-high anisotropic electrical property are capable of detecting piezoresistive effects as well as the local glass transition temperature.
Novel mechanisms of sensitivity and acquired resistance to HSP90 inhibition by ganetespib (2013)

Delivering a Breakthrough Treatment Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease with high unmet medical need. Left untreated, MASH can lead to progressive liver scarring, cirrhosis, liver failure, liver cancer, need for transplant and premature mortality. Our goal is to halt or reverse […]
Expression of Lamp-1 and Lamp-2 and their interactions with galectin-3 in human tumor cells (1998)

Lysosomal-membrane-associated glycoproteins (Lamps) 1 and 2 are rarely found on the plasma membranes of normal cells. There is evidence suggesting an increase in their cell-surface expression in tumor cells, with some data indicating that the adhesion of some cancer cells to the extracellular matrix is partly mediated by interactions between Lamps and E-selectin and between Lamps and galectins (endogenous-galactoside-binding lectins). The present study examined the expression of Lamp-1 and Lamp-2 and their interactions with galectin-3 in different human tumor cell lines. Indirect immunofluorescence staining revealed accumulation of Lamp molecules at the edges of A2058 human metastasizing melanoma cells suggesting that these glycoproteins could participate in cell adhesion. Flow cytometry showed the presence of cell-surface Lamps in A2058, HT1080 (human fibrosarcoma) and CaCo-2 (human colon-adenocarcinoma) cells. Treatment with 2 mM sodium butyrate for 24 and 48 hr resulted in a significant increase in Lamps surface expression. A strong binding of A2058 to recombinant galectin-3 was detected by FACS. The application of 2 and 5 mM butyrate for the same incubation period enhanced galectin-3 binding to Lamps-expressing cells. Our results support the idea that Lamps may be considered a new family of adhesive glycoproteins participating in the complex process of tumor invasion and metastasis.
A Simple Learning Control to Eliminate RF-MEMS Switch Bounce (2009)

A learning control algorithm is presented that reduces the closing time of a radio-frequency microelectromechanical systems switch by minimizing bounce while maintaining robustness to fabrication variability. The switch consists of a plate supported by folded-beam springs. Electrostatic actuation of the plate causes pull-in with high impact velocities, which are difficult to control due to parameter variations from part to part. A single degree-of-freedom model was utilized to design a simple learning control algorithm that shapes the actuation voltage based on the open/closed state of the switch. Experiments on three different test switches show that after 5-10 iterations, the learning algorithm lands the switch plate with an impact velocity not exceeding 0.20 m/s, eliminating bounce. Simulations show that robustness to parameter variation is directly related to the number of required iterations for the device to learn the input for a bounce-free closure.
Coarse-to-fine least squares stereo matching for 3-D reconstruction (1990)

Least squares methods have been used for 3-D reconstruction from digital stereo images. A preliminary estimate of the disparity of points to be matched in the two images is required for the convergence of the method. A new approach based on a Gaussian pyramid decomposition of the stereo images and application of the least squares method at each level of the pyramid is presented. Results obtained from digitised stereo images and 3-D reconstruction are reported.
<title>Processing of Ni-based aero engine components with repetitively Q-switched Nd:YAG lasers</title> (1996)

Aircraft engine industry uses free running high power Nd:YAG lasers for drilling cooling holes into nickel base alloy turbine components. A cw-pumped, Q-switched, high beam quality laser system with 400W laser power is presented. The laser is used to trepan drilling of 1.6mm. Hastelloy X sheets and ceramic coated combustion chamber tubes of the same metal. Cylindrical shape, uniformity, and reproducibility are achieved with a trepan-like drilling setup. The heat load of the workpiece as well as the process time is considerably decreased by employing high-repetition Q-switched lasers.
Annotation Artifacts in Natural Language Inference Data (2018)

Suchin Gururangan, Swabha Swayamdipta, Omer Levy, Roy Schwartz, Samuel Bowman, Noah A. Smith. Proceedings of the 2018 Conference of the North American Chapter of the Association for Computational Linguistics: Human Language Technologies, Volume 2 (Short Papers). 2018.
Stability of the<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:mi>q</mml:mi><mml:mo>/</mml:mo><mml:mn>3</mml:mn></mml:mrow></mml:math>fractional quantum Hall states (2011)

Magnetotransport measurements in a wide GaAs quantum well in which we can tune the Fermi energy (${E}_{F}$) to lie in different Landau levels of the two occupied electric subbands reveal a remarkable pattern for the appearance and disappearance of fractional quantum Hall states at $\ensuremath{\nu}=10/3$, 11/3, 13/3, 14/3, 16/3, and 17/3. The data provide direct evidence that the $q/3$ states are stable and strong even at such high fillings as long as ${E}_{F}$ lies in a ground-state ($N=0$) Landau level of either of the two electric subbands, regardless of whether that level belongs to the symmetric or the antisymmetric subband. Evidently, the node in the out-of-plane direction of the antisymmetric subband does not destabilize the $q/3$ fractional states. On the other hand, when ${E}_{F}$ lies in an excited ($N>0$) Landau level of either subband, the wave function node(s) in the in-plane direction weaken or completely destabilize the $q/3$ fractional quantum Hall states. Our data also reveal that the strength of the $q/3$ fractional states near the crossing of two Landau levels belonging to the two subbands depends on the relative spin polarization of the levels; specifically, the states remain stable very near the crossing if the two levels have parallel spins.
Biosynthesis of vitamin B12 in anaerobic bacteria (1992)

Experiments on the incorporation of erythrose and formate into the 5,6-dimethylbenzimidazole moiety of vitamin B12 are described. In one experiment, a 1:1 mixture of D-[1-13C]erythrose and D-[1-13C]threose was added to a Eubacterium limosum fermentation. The vitamin B12 formed was methylated at N3 of its 5,6-dimethylbenzimidazole part and degraded to 1,5,6-trimethylbenzimidazole. The 13C-NMR spectrum of this compound exhibited a single prominent signal at 109.5 ppm due to 13C labeling in C7. This shows that C1 of erythrose or threose was originally incorporated exclusively into C4 of the 5,6-dimethylbenzimidazole moiety of vitamin B12. In another experiment, sodium [13C]formate was added to a culture of E. limosum. The vitamin B12 isolated was transformed into 1,5,6-trimethylbenzimidazole as before. The 13C-NMR spectrum also showed one prominent signal at 142.8 ppm, evoked by 13C at C2. These results demonstrate that erythrose is incorporated into the base part of vitamin B12 regiospecifically and that formate is the precursor of the C2.
Fully printed flexible carbon nanotube photodetectors (2017)

Here, we report fully printed flexible photodetectors based on single-wall carbon nanotubes and the study of their electrical characteristics under laser illumination. Due to the photothermal effect and the use of high purity semiconducting carbon nanotubes, the devices exhibit gate-voltage-dependent photoresponse with the positive photocurrent or semiconductor-like behavior (conductivity increases at elevated temperatures) under positive gate biases and the negative photocurrent or metal-like behavior (conductivity decreases at elevated temperatures) under negative gate biases. Mechanism for such photoresponse is attributed to the different temperature dependencies of carrier concentration and carrier mobility, which are two competing factors that ultimately determine the photothermal effect-based photoresponse. The photodetectors built on the polyimide substrate also exhibit superior mechanical compliance and stable photoresponse after thousands of bending cycles down to a curvature radius as small as 3 mm. Furthermore, due to the low thermal conductivity of the plastic substrate, the devices show up to 6.5 fold improvement in responsivity compared to the devices built on the silicon substrate. The results presented here provide a viable path to low cost and high performance flexible photodetectors fabricated entirely by the printing process.
High fat diet and liver damage induced by biliary obstruction in the rat (1995)

There is a great body of evidence linking a high fat diet with the formation of gallstones. However, the effect of fat per se on obstructive liver damage (not involving gallstone formation) has not been assessed. The aim of this work was to study the effect of a high fat diet on liver damage induced by bile duct ligation in rats. Male 21-day-old Wistar rats were divided into two groups: group 1 received standard Purina chow diet 5001 containing 4.5% fat, group 2 received Purina chow diet 5001 enriched with 33% pork fat. Animals were allowed food and water ad libitum for 5 weeks. Obstructive jaundice was induced by double ligation and division of the common bile duct. The animals were sacrificed 1 week after biliary obstruction. Control animals were sham operated. Serum bilirubins and alkaline phosphatase, gamma-glutamyl transpeptidase and glutamic pyruvic transminase enzyme activities increased by biliary obstruction. Glycogen content decreased in the bile duct-ligated rats. These effects were more important in the group fed a 33% fat diet. Our results show that a high animal fat diet increases liver damage in experimental biliary obstruction in rats. Owing to our experimental design (bile duct ligation), the effect of a high fat diet cannot be attributed to an increase in the formation of gallstones but a direct effect must be considered. The mechanism by which fat augmented liver damage can be associated with an increase of total bile content and its toxicity.
Anatomic Details of Intradural Channels in the Parasagittal Dura: A Possible Pathway for Flow of Cerebrospinal Fluid (1996)

These channels may represent a pathway for the flow of cerebrospinal fluid from AG to the SSS.
The effect of the microflora on gastrointestinal pH in the chick (1974)

The pH of the contents at 10 positions along the gut of germ‐free and conventional chicks was measured in situ. Similar measurements were made on groups of conventional birds either fasted for 18 h or fully fed. The buffering capacity of caecal contents from germ‐free and conventional birds was also measured by titrating with hydrochloric acid. The pH of the germ‐free gut contents were generally slightly higher than those of their conventional counterparts. These differences were greatest at the midintestine area and caeca. No differences were found between contents of either the proventriculus and gizzard of each group. Starvation increased slightly the pH of intestine and lowered that of crop, proventriculus and rectum. More acid had to be added to conventionalthan germ‐free caecal contents to attain pH 4 both when expressed in relation to the complete contents and per g of dry matter. It was concluded that the microbial flora, by its secretion of acidic metabolites in general had greatest effect on pH in areas of the gut where it was most dense. This was assumed to be due to the secretion of acidic metabolites which caused a consequently greater secretion of neutralising buffering substances by the gut wall.
Challenges of CMOS scaling at below 0.1 μm (2002)

Over the last two decades, CMOS scaling has been the main driver of the electronics industry. During the last few years, the pace of scaling has been accelerating, and we are approaching some fundamental limits. In this paper, some of the key challenges of CMOS scaling, as we move into the 0.1 /spl mu/m generation and beyond, are reviewed. They include challenges faced in short channel effects, gate oxide scaling, I/sub off/ and low voltage operation, metallization, and reliability. A few of the potential solutions to some of these problems are discussed. They include introduction of SOI and novel structures, high-k gate dielectrics, strained Si layers on SiGe, and low-T operation.
CYLINDER OILS: KEY PARAMETERS FOR PERFORMANCE AND LUBRICATION OF CROSSHEAD DIESELS (1996)

Cylinder oils are sophisticated lubricants formulated with high quality base oils and specially selected additives which provide a variety of key properties/characteristics necessary for today's and future crosshead diesel engines. This article reviews the development of a new, improved crosshead diesel cylinder lubricant. Also, the impact of key engine and lubricant parameters on crosshead diesel engine wear and cleanliness aspects are reviewed. Finally, the potential impact of future legislation to control exhaust emissions from crosshead diesels on overall engine and lubricant performance is discussed.
CuInS<sub>2</sub> Thin Films Deposited by ALD (2004)

Abstract At present, chalcopyrites are widely studied as absorber materials for efficient, low‐cost, thin film solar cells. The growth of CuInS 2 thin films by atomic layer deposition (ALD) is studied here. CuInS 2 films are grown on glass, TCO glass (SnO 2 :F‐coated glass), and TiO 2 substrates under pressures in the range 2–10 mbar, with temperatures between 350 °C and 500 °C, using CuCl, InCl 3 , and H 2 S as precursors. The influence of the process conditions on the properties of the material is examined, and the deposition temperature and the pulse length of the precursors are found to be the decisive parameters. The morphology and the composition of the films are investigated using scanning electron microscopy (SEM), X‐ray diffraction (XRD), Rutherford backscattering (RBS), and Raman spectroscopy (RS). Depending on the process conditions, CuInS 2 single phase, Cu‐poor (mixture of CuInS 2 and CuIn 5 S 8 ), or Cu‐rich (mixture of Cu x S and CuInS 2 ) phases are formed.
Fast structural interpretation with structure-oriented filtering (2002)

This paper addresses a new approach to structural interpretation of 3-D seismic data. It is complemented by a second paper which has been submitted to GEOPHYSICS dealing with the technical aspects of structure-oriented filtering. The method and workflow should be viewed against a background of recent changes in the working environment for seismic interpretation. For instance, there has been constant pressure to reduce turnaround time or at least to quickly come up with preliminary results that can influence investment decisions. Integrated teams have been set up to analyze problems in parallel rather than sequential workflows. For the seismic interpreter, this means changing from a one-time transmission of final results to a repetitive process of feeding data into iterative team processes—starting with a crude structural model and followed by increasingly detailed, sophisticated models.
The application of oligonucleotide probes to HLA Class II typing of the DRB sub‐region (1990)

A plan for DRB typing at the sequence level is detailed. Only one polymerase chain amplification reaction is needed and the application of a limited number of short oligonucleotide probes allows an almost complete definition of DRB alleles. The scheme was tested on 40 homozygous cell-lines selected to cover a wide range of specificities, and 40 RFLP-typed controls. The results are presented and discussed. The simplicity and accuracy of this scheme are emphasized.
Chemistry of 3,4-epoxy alcohols. Fragmentation reactions (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemistry of 3,4-epoxy alcohols. Fragmentation reactionsThomas G. Waddell and Pamela A. RossCite this: J. Org. Chem. 1987, 52, 21, 4802–4804Publication Date (Print):October 1, 1987Publication History Published online1 May 2002Published inissue 1 October 1987https://pubs.acs.org/doi/10.1021/jo00230a032https://doi.org/10.1021/jo00230a032research-articleACS PublicationsRequest reuse permissionsArticle Views525Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A low-cost multimode fiber Bragg grating sensor system (2005)

A low-cost fiber optic sensor system based on multimode fiber and an LED light source is presented. A multimode fiber Bragg grating (MMFBG) element is used as a strain sensor. In a matched grating scheme, a MMFBG similar to the sensing one was used as a reference in the receiving unit. For detection of large wavelength shift we demonstrated the feasibility of MMFBG wavelength detection using a single mode fiber fused coupler edge filter. The high cost normally associated with wavelength interrogators for single mode fiber FBG sensors was overcome by the utilization of a low cost multimode fiber pigtailed LED light source. The multimode fiber sensing system has the potential of maintaining much of the advantages of its single mode FBG sensor system counterparts. The MMFBG sensing schemes could be used for short distance, high sensitivity, high speed, strain, temperature and acoustic sensing applications
The involvement of T cell pathogenesis in thyroid-associated ophthalmopathy (2018)

Thyroid-associated ophthalmoapthy (TAO) is the most common orbital disease. As an autoimmune disorder, it is caused by self-reactive lymphocytes that escape immune tolerance, but the mechanism is not fully understood. The basic process of TAO is the infiltration of immune cells in orbital tissues, the activation of orbital fibroblasts (OFs), and the proliferation and differentiation of OFs and lymphocytes. Activated OFs secrete inflammatory regulators, growth factors, and chemokines, thereby maintaining and amplifying the immune responses. The interactions between OFs and lymphocytes lead to the expansion and the remodeling of the orbital tissues, presenting the clinical manifestations of TAO. This review will focus on the role of T cell subsets (Type 1, Type 2, Type 17 helper T cells, and regulatory T cells) in the pathogenesis of TAO. However, we still need further studies to unravel the pathogenesis, to confirm current hypotheses, and to provide novel ideas for appropriate clinical treatment of TAO.
Oral-Mucosal Administration of IFN-α Potentiates Immune Response in Mice (1998)

We studied the effects of oral-mucosal administration of murine interferon-alpha (Mu-IFN-alpha) on immune responses and infection with vaccinia virus (VV) in mice. When Mu-IFN-alpha was administered to sheep red blood cell (SRBC)-sensitized mice for 4 or 5 days, Mu-IFN-alpha significantly enhanced delayed-type hypersensitivity (DTH) and antibody production, with maximum enhancement of each at 1 IU/body. To investigate the antiviral effect of oral-mucosal Mu-IFN-alpha, mice were infected with VV, and Mu-IFN-alpha was administered for 15 days. Pocks were observed in the tail skin of infected mice, and Mu-IFN-alpha at doses of 1, 10, and 100 IU/body significantly suppressed pock formation. Also, VV-specific cytotoxic T cells (CTL) were observed in the spleen from the same mice at 7 days after infection, and Mu-IFN-alpha enhanced CTL activity at doses above 1 IU/body. These results suggest that the oral-mucosal Mu-IFN-alpha may have potentiating effects on cellular and humoral immune responses, which may contribute to its effects against VV.