gebhart/patrepeval huggingface dataset:
Your ticket to the opera for over 40 years (1983)

The most successful public relations/advertising coup by a giant oil company began exactly one year before Pearl Harbor, Dec. 7, 1940, as the child of a marriage of convenience between unlikely partners — Texaco and the Metropolitan Opera. It was comparable to a trail-hardened cowboy exchanging vows with the primmest product of an exclusive finishing school. Some Texaco executives were survivors of the less than genteel life which prevailed in Texas’ first oil boom. The Metropolitan, on the other hand, had long been the artistic plaything of their antithesis, New York City’s ultra-refined 400.
Rerouting Carbon Flux To Enhance Photosynthetic Productivity (2012)

The bioindustrial production of fuels, chemicals, and therapeutics typically relies upon carbohydrate inputs derived from agricultural plants, resulting in the entanglement of food and chemical commodity markets. We demonstrate the efficient production of sucrose from a cyanobacterial species, Synechococcus elongatus, heterologously expressing a symporter of protons and sucrose (cscB). cscB-expressing cyanobacteria export sucrose irreversibly to concentrations of >10 mM without culture toxicity. Moreover, sucrose-exporting cyanobacteria exhibit increased biomass production rates relative to wild-type strains, accompanied by enhanced photosystem II activity, carbon fixation, and chlorophyll content. The genetic modification of sucrose biosynthesis pathways to minimize competing glucose- or sucrose-consuming reactions can further improve sucrose production, allowing the export of sucrose at rates of up to 36.1 mg liter(-1) h illumination(-1). This rate of production exceeds that of previous reports of targeted, photobiological production from microbes. Engineered S. elongatus produces sucrose in sufficient quantities (up to ∼80% of total biomass) such that it may be a viable alternative to sugar synthesis from terrestrial plants, including sugarcane.
2-(Arylmethyl)arylacetic acids as potential antiinflammatory agents (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT2-(Arylmethyl)arylacetic acids as potential antiinflammatory agentsGiovanni Brancaccio, Angelo Larizza, Guglielmo Lettieri, and Pietro MonforteCite this: J. Med. Chem. 1981, 24, 8, 998–1000Publication Date (Print):August 1, 1981Publication History Published online1 May 2002Published inissue 1 August 1981https://pubs.acs.org/doi/10.1021/jm00140a016https://doi.org/10.1021/jm00140a016research-articleACS PublicationsRequest reuse permissionsArticle Views245Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Differential-Mode Biosensor Using Dual Extended-Gate Metal–Oxide–Semiconductor Field-Effect Transistors (2012)

In this paper, we present a differential-mode biosensor using dual extended-gate metal–oxide–semiconductor field-effect transistors (MOSFETs), which possesses the advantages of both the extended-gate structure and the differential-mode operation. The extended-gate MOSFET was fabricated using a 0.6 µm standard complementary metal oxide semiconductor (CMOS) process. The Au extended gate is the sensing gate on which biomolecules are immobilized, while the Pt extended gate is the dummy gate for use in the differential-mode detection circuit. The differential-mode operation offers many advantages such as insensitivity to the variation of temperature and light, as well as low noise. The outputs were measured using a semiconductor parameter analyzer in a phosphate buffered saline (PBS; pH 7.4) solution. A standard Ag/AgCl reference electrode was used to apply the gate bias. We measured the variation of output voltage with time, temperature, and light intensity. The bindings of self-assembled monolayer (SAM), streptavidin, and biotin caused a variation in the output voltage of the differential-mode detection circuit and this was confirmed by surface plasmon resonance (SPR) experiment. Biotin molecules could be detected up to a concentration of as low as 0.001 µg/ml.
Homology between a human apoptosis specific protein and the product of <i>APG5</i>, a gene involved in autophagy in yeast (1998)

Apoptosis specific proteins (ASP) are expressed in the cytoplasm of cultured mammalian cells of various lineages following induction of apoptosis. The cDNA encoding ASP has been cloned from a human expression library and has significant homology to the Saccharomyces cerevisiae APG5 gene which is essential for yeast autophagy. The ASP gene, known as hAPG5, can be transcribed to give mRNAs of 3.3 kbp, 2.5 kbp and 1.8 kbp which are present at comparable levels in viable and apoptotic cells, demonstrating that protein expression must be regulated at the translational level. These data indicate a possible relationship between apoptosis and autophagy and suggest evolutionary conservation in mammalian apoptosis of a degradative process present in yeast.
Endocrinology of the Oestrous Cycle and Puberty (2005)

This chapter contains sections titled: General Definitions Puberty Normal cyclicity
Astaxanthin protects β-cells against glucose toxicity in diabetic db/db mice (2002)

Oxidative stress induced by hyperglycemia possibly causes the dysfunction of pancreatic beta-cells and various forms of tissue damage in patients with diabetes mellitus. Astaxanthin, a carotenoid of marine microalgae, is reported as a strong anti-oxidant inhibiting lipid peroxidation and scavenging reactive oxygen species. The aim of the present study was to examine whether astaxanthin can elicit beneficial effects on the progressive destruction of pancreatic beta-cells in db/db mice--a well-known obese model of type 2 diabetes. We used diabetic C57BL/KsJ-db/db mice and db/m for the control. Astaxanthin treatment was started at 6 weeks of age and its effects were evaluated at 10, 14, and 18 weeks of age by non-fasting blood glucose levels, intraperitoneal glucose tolerance test including insulin secretion, and beta-cell histology. The non-fasting blood glucose level in db/db mice was significantly higher than that of db/m mice, and the higher level of blood glucose in db/db mice was significantly decreased after treatment with astaxanthin. The ability of islet cells to secrete insulin, as determined by the intraperitoneal glucose tolerance test, was preserved in the astaxanthin-treated group. Histology of the pancreas revealed no significant differences in the beta-cell mass between astaxanthin-treated and -untreated db/db mice. In conclusion, these results indicate that astaxanthin can exert beneficial effects in diabetes, with preservation of beta-cell function. This finding suggests that anti-oxidants may be potentially useful for reducing glucose toxicity.
The Rise of the Mouse, Biomedicine's Model Mammal (2000)

SUPPLIERSBAR HARBOR, MAINE-- The mouse's enormous fecundity, low maintenance costs, and physiological and genetic similarity with humans are making it scientists' preferred model of human genetics and physiology, thereby creating an unprecedented demand for inbred rodents. Indeed, the mouse's growing importance as a fuzzy test tube has made it the only mammal other than the human scheduled for complete genetic sequencing, a task that both the National Institutes of Health and the private company Celera have targeted to complete within 5 years. Universities and major commercial breeders are now retooling to meet greater demand for rodents spurred by government and corporate spending on biomedical research.
Microperforated-Panel Wideband Absorbers (1987)

International audience
Assessment of the upper motor neuron in amyotrophic lateral sclerosis (2016)

Clinical signs of upper motor neuron (UMN) involvement are an important component in supporting the diagnosis of amyotrophic lateral sclerosis (ALS), but are often not easily appreciated in a limb that is concurrently affected by muscle wasting and lower motor neuron degeneration, particularly in the early symptomatic stages of ALS. Whilst recent criteria have been proposed to facilitate improved detection of lower motor neuron impairment through electrophysiological features that have improved diagnostic sensitivity, assessment of upper motor neuron involvement remains essentially clinical. As a result, there is often a significant diagnostic delay that in turn may impact institution of disease-modifying therapy and access to other optimal patient management. Biomarkers of pathological UMN involvement are also required to ensure patients with suspected ALS have timely access to appropriate therapeutic trials. The present review provides an analysis of current and recently developed assessment techniques, including novel imaging and electrophysiological approaches used to study corticomotoneuronal pathology in ALS.
Purification of a Gelatin-Degrading Type IV Collagenase Secreted by ras Oncogene-Transformed Fibroblasts (1988)

Connective tissue matrix-degrading metalloproteinases play an important role in cancer invasion. In this report we describe the isolation of a metalloproteinase exhibiting both type IV collagenolytic and gelatinolytic activities from the conditioned medium of NIH-3T3 fibroblasts transformed with DNA containing an activated c-Harvey-ras oncogene from T24 bladder cancer cells. This tumor proteinase was purified by anion exchange chromatography, zinc-chelate Sepharose chromatography, and gel permeation chromatography. The final product was homogeneous on sodium dodecyl sulfate-polyacrylamide gel electrophoresis (relative molecular mass = 67,000). Gelatin zymography revealed two bands of gelatinolytic activity, corresponding to molecular weights of 67,000 and 62,000. Upon immunoblotting with the use of an affinity-purified polyclonal rabbit antibody to a peptide region of type IV collagenase that lacks homology with interstitial collagenase or stromelysin, the purified tumor enzyme was identified as type IV collagenase.
mb-1: a new marker for B-lineage lymphoblastic leukemia (1993)

The expression of the Ig-linked mb-1 polypeptide was analyzed by immunocytochemistry (alkaline phosphatase anti-alkaline phosphatase technique) using a specific monoclonal antibody in 165 cases of acute leukemia, with 88 being lymphoblastic (ALL) and 77 myeloid (AML). The purpose of the study was to investigate the specificity of this reagent for B-lineage cases and its reactivity on leukemias that coexpress myeloid and B-cell antigens (biphenotypic). The majority (89%) of 72 B- cell precursor ALL patients were positive. Of these, mb-1 was expressed in all 9 patients with early-B-ALL (CD10-, c mu-), in all 11 patients with pre-B-ALL (c mu+) and in the single case of B-ALL (smIgM+). Forty- three of 51 patients with common-ALL (CD10+, c mu+) were also positive. All 16 T-lineage ALL patients and 72 (93.5%) of the AML patients examined were mb-1 negative. Four of the 5 mb-1-positive AML patients were considered biphenotypic and expressed other B-cell antigens such as CD10, CD19, and/or cCD22 and all showed rearrangement of the Ig heavy chain genes. Within the AML cases, mb-1 and cCD22 were more useful than other B-cell antigens in detecting biphenotypic cases, and mb-1 showed the highest correlation with the clonal rearrangement of Ig heavy chain genes. These results indicate that mb-1 is a sensitive and specific reagent for B-lineage blasts that will aid in the classification of B-cell precursor ALL and in the identification of biphenotypic leukemia presenting as AML.
Ionische Adsorptionszustände organischer Moleküle im hohen elektrischen Feld (1971)

Abstract Die Möglichkeit einer feldinduzierten ionischen Adsorption wird aufgezeigt. Feldadsorbierte Ionen promotieren lokal die Feldionisierungswahrscheinlichkeit. Reaktionen mit Oberflächenionen führen zur Desorption von Ionen mit einem niedrigen Appearance‐Potential.
Raynaud Phenomenon of the Nipple in Breastfeeding Mothers (2012)

Most patients were treated with antifungals before presentation without resolution of nipple pain. Nifedipine appears to be an effective medication for the treatment of Raynaud phenomenon of the nipple. With appropriate management of Raynaud phenomenon,breastfeeding mothers demonstrated improvement of nipple pain. Raynaud phenomenon of the nipple should be considered in the differential diagnosis of nipple pain during lactation.
SOME PROPERTIES OF AN ESTERASE DERIVED FROM PREPARATIONS OF THE FIRST COMPONENT OF COMPLEMENT (1957)

Studies on an esterase derived from partially purified preparations of the first component of complement are described. The esterase hydrolyzed certain synthetic amino acid esters, among which N-acetyl-L-tyrosine ethyl ester was most susceptible. This was hydrolyzed maximally between pH 7.5 and 8.2, and at 41 degrees C. The esterase could not be identified with other previously described hydrolytic enzymes. An esterase with similar properties could also be eluted from antigen-antibody aggregates which had been treated with serum. Human serum contained a heat-labile inhibitor of the esterase which could not be identified with any of the known components of complement. The esterase was also inhibited by certain reducing agents. The experiments described support the early hypothesis that complement exerts its action enzymatically, but the physiological role of the esterase derived from preparations of complement is not yet clear.
Photoreaction of <i>N</i>,<i>N</i>′-Dibromo-2,5-piperazinedione (1981)

Abstract The photolysis of N,N′-dibromo-2,5-piperazinedione in dichloromethane gave an unstable photoproduct. The alcoholysis of the photoproduct in the presence of a small amount of hydrogen bromide yielded 3,6-diethoxy-2,5-piperazinedione and its alcoholyzed products, ethyl diethoxyacetate, ethyl 2-(diethoxyacetylamino)-2-ethoxyacetate, N-(1-ethoxy-1-ethoxycarbonylmethyl)oxamide, and ethyl N-(diethoxyacetyl)glycinate. The reactions of the photoproduct with other nucleophiles also gave the corresponding substituted 2,5-piperazinediones. The structure of the primary photoproduct was deduced to be 3,6-dibromo-2,5-piperazinedione on the basis of these observations.
Synthesis and molecular modeling: Related approaches to progress in brassinosteroid research (1997)

In the field of brassinosteroids, which are potent plant growth regulators, we have developed a quantitative structure-activity relationship study to develop knowledge from a structural point of view and to find out new requirement definitions. This will help identify other suitable active brassinosteroid derivatives with a good activity/synthetic cost ratio for further application in agriculture. The methodology used to achieve this goal represents a multidisciplinary study involving synthesis, molecular modeling calculations, and bioactivity evaluation. The influence of different molecular properties in the bioactivity of a set of synthetic compounds (i.e., molecular electrostatic potential and the ability to form H bonds) is discussed. The molecular electrostatic potential is expressed in terms of the electrostatic Carbó similarity index (CI) between brassinolide (1) and other brassinosteroids. We have found that the electrostatic charges of the functional groups play an important role in the description of the activity, as evidenced by its good correlation with the CI in most cases. Deviation from this rule could be explained by the H bonding abilities of some of these compounds, which we believe may play an essential role in binding to the natural receptors.
Multiple Roles of CD4 and CD8 in T Cell Activation (2010)

The field of T cell biology was ushered in with a series of discoveries in the 1960s demonstrating that the thymus was not a vestigial organ lacking important biologic function but instead was critical for the host to mount both humoral and cell-mediated immune effector functions ([1][1]). Why the
A Method for Parallel Adaptive Volterra Filter Using RLS Algorithm (2006)

In recent years, the adaptive Volterra filter (AVF) based on discrete Volterra series has been used to identify a nonlinear system, remove nonlinear distortion etc. Since AVF is an extension of the conventional linear digital filters, the algorithms used in linear filters are easily used in AVF, and AVF is sufficiently approximate to the complicated systems due to its general function expansion. However, AVF has a problem that the calculation work becomes extremely large for long memory length, or for filtering high-order nonlinear characteristic. This paper presents a type of parallel adaptive Volterra filter (PAVF) to decrease the calculation complexity. Finally, to illustrate the effectiveness of the proposed method, the results of computer simulation with recursive least squares (RLS) algorithm are presented.
Prognostic significance of T helper 1 and 2 and T cytotoxic 1 and 2 cells in patients with non-small cell lung cancer. (2005)

A high Th1/Th2 ratio in peripheral blood is a negative prognostic factor, especially in pathological Stage II or III non-small cell lung cancer patients.
Microbes versus microbes: immune signals generated by probiotic lactobacilli and their role in protection against microbial pathogens (2002)

Probiotic lactic acid bacteria can signal the immune system through innate cell surface pattern recognition receptors or via direct lymphoid cell activation. In some cases, this action has been shown to be sufficient to modulate local- and systemic-level in vivo immune responses. Practical applications of probiotics include their use in anti-tumour and anti-allergy immunotherapy, but there is also increasing evidence that some probiotics can stimulate a protective immune response sufficiently to enhance resistance to microbial pathogens. This review outlines the experimental and clinical evidence for enhanced anti-microbial immune protection by probiotic lactic acid bacteria, focussing on those studies where a correlative or suggestive link has been shown between immune modulation and enhanced protection.
Contaminant-free cultivation of Pfiesteria shumwayae (Dinophyceae) on a fish cell line (2005)

Geographically distinct strains of the heterotrophic dinoflagellate Pfiesteria shumwayae were cultivated on a fish cell line in the apparent absence of bacteria and other microbial contaminants. Cultures were established with a high rate of success by inoculating single purified P. shumwayae cells into fish cell cultures containing a simple saltwater medium suitable for both cell types, and resulting isolates were serially cultivated on fish cells for months without visible signs of abnormality or reduced viability. P. shumwayae fed phagocytically on the fish cells and exhibited higher cell production than reported using other culturing methods. Compared to previous methods of studying the interaction between Pfiesteria spp. and fishes, this system enabled closer and more direct observation of the dinoflagellates and was also more economical and sustainable as a culturing method. The absence of bacteria and other contaminating microorganisms should facilitate important physiological and biochemical investigations. The methods used were inadequate for cultivating strains of P. piscicida, suggesting a possible difference in nutritional requirements between the 2 Pfiesteria species.
N-myristoylated proteins, key components in intracellular signal transduction systems enabling rapid and flexible cell responses (2010)

N-myristoylation, one of the co- or post-translational modifications of proteins, has so far been regarded as necessary for anchoring of proteins to membranes. Recently, we have revealed that N(alpha)-myristoylation of several brain proteins unambiguously regulates certain protein-protein interactions that may affect signaling pathways in brain. Comparison of the amino acid sequences of myristoylated proteins including those in other organs suggests that this regulation is involved in signaling pathways not only in brain but also in other organs. Thus, it has been shown that myristoylated proteins in cells regulate the signal transduction between membranes and cytoplasmic fractions. An algorithm we have developed to identify myristoylated proteins in cells predicts the presence of hundreds of myristoylated proteins. Interestingly, a large portion of the myristoylated proteins thought to take part in signal transduction between membranes and cytoplasmic fractions are included in the predicted myristoylated proteins. If the proteins functionally regulated by myristoylation, a posttranslational protein modification, were understood as cross-talk points within the intracellular signal transduction system, known signaling pathways could thus be linked to each other, and a novel map of this intracellular network could be constructed. On the basis of our recent results, this review will highlight the multifunctional aspects of protein N-myristoylation in brain.
Assembly and solder joint reliability of plastic ball grid array with lead-free versus lead-tin interconnect (2002)

Many governments, particularly in Japan and Europe, have proposed laws reducing or eliminating the use of lead (Pb) and other toxic substances in products in an effort to decrease landfill pollution and ground water contamination. Thus, there exists a need for lead-free components in order to comply with government standards and to meet market demands for "green" products. As the semiconductor industry moves towards environmentally friendly components, it is important that their assembly and reliability be well characterized. This paper will describe experiments performed to determine the interconnect reliability of a peripherally leaded 1.0 mm pitch, 324 PBGA with lead-free (tin-silver) versus conventional (tin-lead-silver) solder balls. Assembly was performed with lead-free versus eutectic solder paste. Two different PBGA substrate manufacturers were evaluated and the test boards used had an immersion gold over electroless nickel surface finish. The assembled boards were thermal cycled in both -40 to 125 and -50 to 150/spl deg/C until >50% failure to compare lifetime of the lead-based and lead-free material. Solder joint failures were detected with continuous in-situ electrical monitoring and most were then verified with dye penetrant. Additionally, solder ball shear testing versus 125 and 150/spl deg/C bake out to 1,008 hrs was performed on lead and no-lead parts using one of the two substrate suppliers. Ball shear as a function of number of reflows was also performed. Scanning electron microscopy (SEM) was used to analyze the elemental content and intermetallic thickness of both ball sheared and board-level cycled parts. The data from the aforementioned experiments suggests that the lead-free 324 PBGA packages are at least as reliable as the lead containing ones.