gebhart/patrepeval huggingface dataset:
Transient Cerebral Ischemia Induces Aberrant Neuronal Cell Cycle Re-entry and Alzheimer's Disease-like Tauopathy in Female Rats (2004)

Aberrant mitosis occurs in many tauopathy-related neurodegenerative diseases and is believed to precede the formation of neurofibrillary tangles. In this study, we report for the first time that transient cerebral ischemia induces aberrant mitotic proteins and hyperphosphorylation of tau protein with neurofibrillary tangle-like conformational epitopes in adult female rat cortex. Following transient cerebral ischemia in rats, initiation of apoptosis precedes and is potentially integrated with subsequent aberrant mitosis and tau hyperphosphorylation. Furthermore, inhibition of mitosis-related cyclin-dependent kinases (Cdks) by roscovitine significantly reduced the hyperphosphorylation of tau. Administration of the female sex steroid and potent neuroprotective agent, 17beta-estradiol, reduced ischemia-reperfusion-induced cerebral damage and the subsequent aberrant mitosis and tauopathies. These results provide a neuropathological basis for the higher prevalence of dementia in stroke patients and support the hypothesis that apoptosis and aberrant mitosis are integrated pathological events in neurons that may play a critical role in the development of Alzheimer's disease and other tauopathy-related neuropathology.
A policy based role framework for access control (1996)

Article A policy based role framework for access control Share on Authors: Emil C. Lupu Department of Computing, Imperial College, 180 Queen's Gate London SW7 2BZ, UK Department of Computing, Imperial College, 180 Queen's Gate London SW7 2BZ, UKView Profile , Damian A. Marriott Department of Computing, Imperial College, 180 Queen's Gate London SW7 2BZ, UK Department of Computing, Imperial College, 180 Queen's Gate London SW7 2BZ, UKView Profile , Morris S. Sloman Department of Computing, Imperial College, 180 Queen's Gate London SW7 2BZ, UK Department of Computing, Imperial College, 180 Queen's Gate London SW7 2BZ, UKView Profile , Nicholas Yialelis Department of Computing, Imperial College, 180 Queen's Gate London SW7 2BZ, UK Department of Computing, Imperial College, 180 Queen's Gate London SW7 2BZ, UKView Profile Authors Info & Claims RBAC '95: Proceedings of the first ACM Workshop on Role-based access controlDecember 1996 Pages 11–eshttps://doi.org/10.1145/270152.270171Online:01 December 1996Publication History 16citation741DownloadsMetricsTotal Citations16Total Downloads741Last 12 Months13Last 6 weeks3 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
The onset of secondary phase precipitation during synthesis of heteroepitaxial Si1−<i>x</i>−<i>y</i>Ge<i>x</i>C<i>y</i> on Si(100) (1996)

An upper temperature limit of 450 °C has been established for growth of heteroepitaxial Si1−x−yGexCy solid solutions with substitutional C on Si(100) by combined ion and molecular beam deposition (CIMD). At 450 °C infrared absorption spectroscopy shows that C is on substitutional sites and no SiC precipitates are detected, whereas at 560 °C the substitutional C signal is much smaller but SiC precipitates are still not detected. High resolution transmission electron microscopy shows that Si1−x−yGexCy films deposited at 560 °C exhibit Ge deficient, coherent, secondary phase clusters in the cubic diamond matrix, which are not seen in films deposited at 450 °C. These observations suggest that the clusters are C-rich, Ge-deficient precursors to SiC, with a lattice which is distorted but free of extended defects. Ion channeling results indicate that the Si1−x−yGexCy films might have a distribution of different bond lengths.
Role of Homeostatic Chemokine and Sphingosine‐1‐Phosphate Receptors in the Organization of Lymphoid Tissue (2003)

Chemokines regulate both homeostatic leukocyte recirculation and trafficking to sites of infection and inflammation. Apart from the well-established physiological functions, chemokines receive growing interest for their role in pathophysiological processes such as autoimmune diseases, cancer, and allograft rejection. The chemokine receptor CCR7, which is responsible for directing T cells, B cells, and dendritic cells (DCs) into secondary lymphoid organs and their precise positioning therein, has already been implicated in lymphoid organ infiltration by neoplastic cells and the localization of metastasis formation. We have shown that the differential expression of CCR7 by neoplastic cells in two entities of Hodgkin's disease (HD), classic HD (cHD) and the nodular lymphocyte predominant HD (NLPHD), may account for the differences observed in tumor cell dissemination within the affected lymph nodes. Because of the prominent role of the chemokine receptors CCR7 and CXCR5 in lymphocyte homing to secondary lymphoid organs, we hypothesized that they may also be involved in the action of FTY720, a synthetic immunosuppressant inducing lymphopenia. By using CXCR5 and CCR7 knockout mice, we have tested for a possible function of these receptors in the FTY720-induced migration of lymphocytes into Peyer's patches (PPs) and peripheral lymph nodes (PLNs). Lymphopenia is noticeably delayed in mice lacking CCR7, whereas CXCR5 knockout mice show a significant reduction of lymphocyte accumulation in secondary lymphoid organs that are infrequently present in these mice. However, FTY720-induced lymphocyte sequestration appears to be essentially independent of CCR7 and CXCR5.
Telematics and ITS integrated vehicular antenna with CRLH-TL parasitic element (2012)

Vehicle-infrastructure Cooperative Systems (In this paper we call it “ITS” because of a space constraint) is one of measures that may help to reduce traffic accident through vehicles and roadside infrastructure work together [1]. It provide driver cognitive support to prevent miscalculation or against the traffic rule through communication between road infrastructure and vehicles about traffic regulatory information or existence of pedestrians and other vehicles. It originally expected 720-MHz band for Vehicle-infrastructure Cooperative Systems and now 760MHz band is allocated for this service. In any case, the frequency band closes a mobile phone frequency.
Vaccines and Vaccination (2001)

More than 70 bacteria, viruses, parasites, and fungi are serious human pathogens.1 Vaccines are available against some of these agents and are being developed against almost all the other bacteria and viruses and about half of the parasites. Table 1 lists infections for which there are now licensed vaccines and those for which a candidate vaccine has undergone a phase 3 clinical trial,2 indicating that a vaccine will probably be licensed within 5 to 10 years.Traditionally, attenuated vaccines were made by repeated passaging of the infectious agent in tissue culture or animal hosts until its virulence was greatly decreased but its . . .
Significance of ERK cascade compared with JAK/STAT and PI3-K pathway in gp130-mediated cardiac hypertrophy (2000)

We compared the role of the Raf-1/mitogen-activated protein kinase/extracellular signal-regulated protein kinase (MEK)/extracellular signal-regulated protein kinase (ERK)/p90(RSK) cascade in gp130-mediated cardiac hypertrophy with the contribution of the Janus kinase (JAK)/signal transduction and activation of transcription (STAT) and phosphatidylinositide 3-kinase (PI3-K) pathways. Primary cultured neonatal rat cardiomyocytes were stimulated with leukemia inhibitory factor (LIF). LIF sequentially activated Raf-1, MEK1/2, ERK1/2, and p90(RSK). We used PD-98059 (a specific MEK inhibitor), AG-490 (a JAK2 inhibitor), and wortmannin (a PI3-K inhibitor) to confirm that this cascade was independent of the JAK/STAT and PI3-K/p70 S6 kinase (S6K) pathways. PD-98059, AG-490, and wortmannin suppressed the LIF-induced increase in [(3)H]phenylalanine uptake by 54.7, 21.5, and 25.6%, respectively, and inhibited the increase in cell area by 61.2, 42.8, and 39.2%, respectively. Reorganization of myofilaments was predominantly suppressed by AG-490. LIF-induced expression of c-fos, brain natriuretic peptide, and skeletal alpha-actin mRNA was markedly suppressed by PD-98059 and moderately suppressed by wortmannin and AG-490. Atrial natriuretic peptide was significantly suppressed by AG-490. These findings indicate that this pathway is critically involved in protein synthesis, induction of c-fos, brain natriuretic peptide, and skeletal alpha-actin expression and is partially involved in myofilament reorganization and atrial natriuretic peptide induction in gp130-mediated cardiac hypertrophy.
Whiter brights with lasers (2013)

I am standing in a twilit underground lab looking at the most powerful car headlight in the world. Its source, a blue-laser diode, is 1000 times as bright as an LED but uses just two-thirds the energy. I had to surrender my passport to see it, for I'm at BMW's highly secure, steel-and-glass research mecca, the FIZ (for Forschungs- und Innovationszentrum, or Research and Innovation Center), an immense complex in Munich replete with workshops, clay modelers¿ "caves," and a vast wind tunnel.
Synthesis, crystal structure and properties of a one-dimensional<scp>L-</scp>valinate bridged coordination polymer: [Cu<sub>2</sub>(<scp>L</scp>-val)<sub>2</sub>(bpy)<sub>2</sub>]<i><sub>n</sub></i>·2<i>n</i>ClO<sub>4</sub>·2<i>n</i>H<sub>2</sub>O (2005)

The complex [Cu2(L-val)2(bpy)2] n ·2nClO4·2nH2O (L-val = L-valinate, bpy = 2,2′-bipyridine) has been synthesized and investigated by elemental analysis, IR and UV spectroscopy, DTA–TG analysis and X-ray diffraction methods. The complex crystallizes in the monoclinic space group P21 with two molecules in a unit cell of dimensions a = 10.0954(12), b = 8.1245(9), c = 23.297(3) Å, β = 102.447(2)°, V = 1865.9(4) Å3, D c = 1.614 g/cm3, μ = 1.357 mm−1, F(000) = 932, R = 0.0337, wR = 0.0847 for 7024 unique reflections. Single-crystal structure analysis reveals that cations have a one-dimensional polymeric structure, with two Cu(bpy)2+ units bridged by a carboxylate group of L-valinate. Each Cu2+ ion is in a slightly distorted square-pyramidal geometry, with the bpy(N,N′) and L-val(N,O) acting as bidentate ligands in the equatorial plane and another carboxylate oxygen atom from a symmetry-related neighboring L-valinate ion in the apical position. IR and UV spectra and thermal analysis are in agreement with the crystal structure.
Isolation of aphidicolin as a root growth inhibitor from Harziella entomophilla. (1978)

In the course of our screening research for new plant growth regulators among metabolites of microorganisms, we noticed the presence of a root growth inhibitor of lettuce and rice seedlings in the culture broth of
Modeling human performance of pen stroke gestures (2007)

This paper presents a quantitative human performance model of making single-stroke pen gestures within certain error constraints in terms of production time. Computed from the properties of Curves, Line segments, and Corners (CLC) in a gesture stroke, the model may serve as a foundation for the design and evaluation of existing and future gesture-based user interfaces at the basic motor control efficiency level, similar to the role of previous "laws of action" played to pointing, crossing or steering-based user interfaces. We report and discuss our experimental results on establishing and validating the CLC model, together with other basic empirical findings in stroke gesture production.
Empirical Metadata Maintenance in Source Code Development Process (2015)

A management of software development process is a crucial part of the software engineering, from which the success of software projects is dependent. This management mostly relays upon quality and freshness of software metrics, especially empirical software metrics. But empirical software metrics are sensitive to source code modifications and also to developers' activities. In this paper we proposed approach for a maintenance of empirical metadata stored in information tags. The approach covers main maintenance actions - creating missing, repairing invalidated and removing unrepairable information tags. The maintenance is provided via tagging rules executed after matching predefined templates in a stream of developers' actions. We also introduces a set of information tags for supporting software development process and we describe their utilization in teaching a subject Team project.
Content management in a mobile ad hoc network: Beyond opportunistic strategy (2011)

We study the challenging problem of strategic content placement in a dynamic MANET. Existing content placement techniques cannot cope with such network dynamics since they are designed for fixed networks. Opportunistic caching approaches are insufficient as they do not actively manage contents for certain goals. In this paper, we present a novel content management approach called LACMA, which leverages the location information available to mobile devices via GPS. The main idea of LACMA is to bind data to geographic location (as opposed to network nodes). This location-based strategy decouples the content placement problem from the changing network topology, and allows us to design an optimization framework even in a dynamic MANET environment. We present key components of LACMA used for strategic content placement and content-location binding (through proactive content push). We evaluate LACMA and compare its performance with existing caching schemes and show that LACMA considerably outperforms existing schemes over a wide range of scenarios.
Hot-Carrier Thermalization in Amorphous Silicon (1981)

Thermalization of photoinduced carriers in $a$-Si and $a$-Si: H was studied with use of subpicosecond-pump and probe techniques with parallel and perpendicular polarizations. The underlying process was identified as hot-carrier absorption whose cross section increases with the carrier excess energy. The energy dissipation rate in $a$-Si is \ensuremath{\simeq}0.5 eV/ps ($\ensuremath{\simeq}\ensuremath{\hbar}{{\ensuremath{\nu}}^{2}}_{\mathrm{phonon}}$) and is less than 0.1 eV/ps in $a$-Si: H; Fr\"ohlich interaction with polar phonons can explain this smaller rate. A photoinduced dichroism associated with polarization memory was observed.
Natural flower resources of orchids in Guangdong mountain area (2001)

Based on the preliminary statistical data, there are plenty of natural plants of orchids, including 87 species of flowering ornaments, 43 species of foliage plants and 18 species of flowering and foliage plants in Guangdong mountain area. The geographical distribution, eccosystem characterization and growth habits of the plants are introduced and the suggestions for protecting and developing the natural orchids resources are put forward in this paper.
The Key Management of the Encrypted Database Based on XML (2007)

Encryption is an effective way to enhance the security of the database. The key management is the important factor to ensure the security of the encrypted database. But the current scheme of the key management has some security problem and is easily attacked. Face to this problem, the new scheme about key management base on XML is proposed in this paper. A XML file that has the tree structure is used to mange the working key that is protected by the primary key. Lt can not only manage the working key efficiently, but also enhance the security of the encrypted database.
Memory Latency Reduction via Thread Throttling (2010)

Memory Wall is a well-known obstacle to processor performance improvement. The popularity of multi-core architecture will further exaggerate the problem since the memory resource is shared by all cores. Interferences among requests from different cores may prolong the latency of memory accesses thereby degrading the system performance. To tackle the problem, this paper proposes to decouple application threads into compute and memory tasks, and restrict the number of concurrent memory tasks to avoid the interference among memory requests. Yet with this scheduling restriction, a CPU core may unnecessarily stay idle, which incurs adverse impact on the overall performance. Therefore, we develop a memory thread throttling mechanism that tunes the allowable memory threads dynamically under workload variation to improve system performance. The proposed run-time mechanism monitors memory and computation ratios of a program for phase detection. It then decides the memory thread constraint for the next program phase based on an analytical model that can estimate system performance under different constraint values. To prove the concept, we prototype the mechanism in some real-world applications as well as synthetic workloads. We evaluate their performance on real machines. The experimental results demonstrate up to 20% speedup with a pool of synthetic workloads on an Intel i7 (Nehalem) machine and match with the speedup estimated by the proposed analytical model. Furthermore, the intelligent run-time scheduling leads to a geometric mean of 12% performance improvement for real-world applications on the same hardware.
Refractive Index Change Due to Volume-Phase Transition in Polyacrylamide Gel Nanospheres for Optoelectronics and Bio-photonics (2009)

Poly(N-isopropylacrylamide) (PNIPAM) hydrogel nanospheres response to global temperature stimuli across the low critical solution temperature is studied as the water content in the polymer network is modified. The refractive index of gel nanoparticles was measured as a function of temperature using spectroscopic ellipsometry. The volume of the nanospheres reduces by 40% resulting in a modification of light scattering properties of the medium. A change in temperature from 33 to 34 °C results in a volume contraction of nanospheres which is accompanied by 8–10% enhancement in the refractive index of the gel network.
Illumination Based on High-Power White Light-Emitting Diode Array (2012)

In this study, a high-power white light-emitting diode (LED) array for illumination is realized and investigated. Since the brightness and life-span of an LED depend markedly on its thermal design and the stability of its power, some issues that govern the structure of the heat dissipation components and the power supply circuit are initially discussed. TracePro optical analysis and CFdesign thermal analytic software are adopted to analyze the effects of temperature and the heat dissipation module on the LEDs. Optical measurements of the constructed LED array reveal that such an array can be applied for lighting. A comparison of this array with other traditional lighting sources, such as high-pressure sodium lamps and mercury lamps, demonstrates that the luminescent efficiency of the designed LED array lamp is high. Furthermore, the results concerning energy consumption reveal that an LED lamp that is formed from such an array consumes very little energy.
Constellation: a visualization tool for linguistic queries from MindNet (2003)

Constellation is a visualization system for the results of queries from the MindNet natural language semantic network. Constellation is targeted at helping MindNet's creators and users refine their algorithms, as opposed to understanding the structure of language. We designed a special-purpose graph layout algorithm which exploits higher-level structure in addition to the basic node and edge connectivity. Our layout prioritizes the creation of a semantic space to encode plausibility instead of traditional graph drawing metrics like minimizing edge crossings. We make careful use of several perceptual channels both to minimize the visual impact of edge crossings and to emphasize highlighted constellations of nodes and edges.
VirtualCluster: Customizing the Cluster Environment through Virtual Machines (2008)

Software packages in working clusters are often once installed and kept unchanged for a very long time except for some bug fix, security enhancement, or small upgrades. This is due to the sharing property of the clusters among many users or institutes. They do not want to disturb each other while changing the infrastructure software packages. Such typical usage scenario means newly developed technologies cannot be deployed and used quickly in the traditional cluster environments. With the fast development of the virtual machine technologies, we are seeking the ways on how to use the virtual machines to manage the cluster environments efficiently. We believe that this will be more flexible and easy for using or management of clusters. Users of the clusters can be provided with customized ldquovirtual clustersrdquo instead of accessing physical nodes. This paper will discuss the new trends in virtualization cluster management with their design objectives, challenges, as well as our prototype system, named VirtualCluster with its design and implementation.
Potential Dengue Virus-Triggered Apoptotic Pathway in Human Neuroblastoma Cells: Arachidonic Acid, Superoxide Anion, and NF-κB Are Sequentially Involved (2000)

Direct in vivo evidence for the susceptibility of human neuronal cells to dengue virus has not been reported. In this study, we demonstrated that type 2 dengue (DEN-2) virus infection induced extensive apoptosis in the human neuroblastoma cell line SK-N-SH. Phospholipase A(2) (PLA(2)) was activated by DEN-2 infection, which led to the generation of arachidonic acid (AA). Inhibition of PLA(2) activity by the PLA(2) inhibitors, AACOCF(3) and ONO-RS-082, diminished DEN-2 virus-induced apoptosis. In contrast, the cyclooxygenase inhibitors aspirin and indomethacin, thought to increase AA accumulation by blocking AA catabolism, enhanced apoptosis. Exogenous AA induced apoptosis in a dose-dependent manner. Superoxide anion, which is thought to be generated through the AA-activated NADPH oxidase, was increased after infection. Pretreatment with superoxide dismutase (SOD) protected cells against DEN-2 virus-induced apoptosis. Furthermore, generation of superoxide anion was blocked by AACOCF(3). In addition, the transcription factors, NF-kappaB and c-Jun, were found to be activated after DEN-2 virus infection. However, pretreatment of cells with oligodeoxynucleotides containing NF-kappaB, but not c-Jun, binding sites (transcription factor decoy) strongly prevented dengue virus-induced apoptosis. The finding that AACOCF(3) and SOD significantly block activation of NF-kappaB suggests that this activation is derived from the AA-superoxide anion pathway. Our results indicate that DEN-2 virus infection of human neuroblastoma cells triggers an apoptotic pathway through PLA(2) activation to superoxide anion generation and subsequently to NF-kappaB activation. This apoptotic effect can be either directly derived from the action of AA and superoxide anion on mitochondria or indirectly derived from the products of apoptosis-related genes activated by NF-kappaB.
Electrolyte System for High Voltage Li-Ion Cells (2016)

Ethylene carbonate is a co-solvent used in virtually every lithium ion cell produced today because it enables operation of both the positive and negative electrodes. Most battery scientists believe ethylene carbonate is essential. Surprisingly, totally removing all ethylene carbonate from typical organic carbonate-based electrolytes and adding small amounts of electrolyte additives creates cells that are better than those containing ethylene carbonate. For example an electrolyte of only 2% vinylene carbonate and 98% ethyl methyl carbonate, with selected additives, provides excellent performance to Li[Ni0.4Mn0.4Co0.2]O2/graphite cells cycled up to 4.4 V which increases their energy density by at least 10%. The cells have low impedance, low rates of electrolyte oxidation, good graphite passivation, low gas generation, acceptable conductivity and low cost. This discovery opens an entirely new space for electrolyte development.