gebhart/patrepeval huggingface dataset:
A SCALABLE GPU-BASED APPROACH TO SHADING AND SHADOWING FOR PHOTOREALISTIC REAL-TIME AUGMENTED REALITY (2007)

Visually realistic Augmented Reality (AR) entails addressing several difficult problems. The most difficult problem is that of rendering the virtual objects with illumination which is consistent with the illumination of the real scene. The paper describes a complete AR rendering system centered around the use of High Dynamic Range environment maps for representing the real scene illumination. The main contribution lies in a novel, physically-based approach to rendering shadows cast by virtual objects without changing the shadows already present in the images of the real scene. The proposed approach effectively involves real-time estimation of the diffuse albedos of the real scene, and essentially relighting these areas to take virtual shadows into account. Another contribution lies in the fact that the proposed approach is designed to run on graphics hardware and is scalable in the sense that it offers a simple way to balance performance with visual quality.
Increased inflammation and lethality of <i>Dusp1</i><sup>−/−</sup> mice in polymicrobial peritonitis models (2010)

The mitogen-activated protein kinase phosphatase Dusp1 (also known as MKP-1) is essential for control of the inflammatory response to systemic challenge with the lipopolysaccharide of Gram-negative bacteria. Here, we have investigated the consequences of Dusp1-deficiency in colon ascendens stent peritonitis (CASP) and caecal ligation and puncture (CLP), two mouse models of septic peritonitis. Following CASP, Dusp1(-/-) mice had increased serum levels of CCL4, interleukin-10 (IL-10) and IL-6, with differences from wild-type mice being dependent on severity of sepsis. These cytokines, along with inducible nitric oxide synthase messenger RNA, were also expressed at higher levels in spleen and liver. Similar over-production of these cytokines was detected in the CLP model, with even larger differences from wild-type mice. Despite the increased inflammatory response, bacterial clearance was impaired in Dusp1(-/-) mice subjected to CASP and CLP. Dusp1(-/-) mice suffered increased lethality in both peritonitis models. Together our data indicate that exaggerated inflammatory responses to gut bacteria introduced into the peritoneum in the absence of Dusp1 do not help to control bacterial replication but are detrimental for the host.
Comments, with reply, on 'comparison of multiquantum well, graded barrier, and doped quantum well GaInAs/AlInAs avalanche photodiodes: a theoretical approach by K. Brennan (1989)

It is pointed out that the lucky drift model complements the Monte Carlo simulation used in a previous paper (ibid., vol.QE-23, no.8, p.1273-82, 1987) to predict the performance of avalanche photodiodes containing multilayer structures. In his reply, the author agrees with the basic promise raised by the commenter, that models such as luck drift serve to complement detailed, first principles models like the Monte Carlo approach, aiding in their interpretation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Association of <scp>N</scp>‐acetyltransferase 2 and cytochrome <scp>P</scp>450 2<scp>E</scp>1 gene polymorphisms with antituberculosis drug‐induced hepatotoxicity in <scp>W</scp>estern <scp>I</scp>ndia (2013)

Increased susceptibility to isoniazid (INH)-induced hepatotoxicity due to presence of NAT2 SA polymorphism was demonstrated in Western Indian population. NAT2 genotyping can therefore serve as an important tool for identifying patients predisposed to anti-TB DIH.
Knowledge Discovery in Databases: An Attribute-Oriented Approach (1992)

Knowledge discovery in databases, or data mining, is an important issue in the development of data- and knowledge-base systems. An attribute-oriented induction method has been developed for knowledge discovery in databases. The method integrates a machine learning paradigm, especially learning-from-examples techniques, with set-oriented database operations and extracts generalized data from actual data in databases. An attribute-oriented concept tree ascension technique is applied in generalization, which substantially reduces the computational complexity of database learning processes. Different kinds of knowledge rules, including characteristic rules, discrimination rules, quantitative rules, and data evolution regularities can be discovered efficiently using the attribute-oriented approach. In addition to learning in relational databases, the approach can be applied to knowledge discovery in nested relational and deductive databases. Learning can also be performed with databases containing noisy data and exceptional cases using database statistics. Furthermore, the rules discovered can be used to query database knowledge, answer cooperative queries and facilitate semantic query optimization. Based upon these principles, a prototyped database learning system, DBLEARN, has been constructed for experimentation.
Foot-and-mouth disease virus protease 3C induces specific proteolytic cleavage of host cell histone H3 (1990)

In foot-and-mouth disease virus (FMDV)-infected cells, the disappearance of nuclear protein histone H3 and the simultaneous appearance of a new chromatin-associated protein termed Pi can be observed (P. R. Grigera and S. G. Tisminetzky, Virology 136:10-19, 1984). We sequenced the amino terminus of protein Pi and showed that Pi derives from histone H3 by proteolytic cleavage. The 20 N-terminal amino acid residues of histone H3 are specifically cleaved off early during infection. Truncated histone H3 remains chromatin associated. In addition, we showed that the histone H3-Pi transition is catalyzed by the FMDV 3C protease. The only known function of the viral 3C protease was, until now, the processing of the viral polyprotein. The viral 3C protease is the only FMDV protein required to induce the histone H3-Pi transition, as well as being the only viral protein capable of cleaving histone H3. No viral precursor fusion protein is needed for this specific cleavage as was reported for the processing of the poliovirus P1 precursor polyprotein by 3C/D protease. As the deleted part of the histone H3 corresponds to the presumed regulatory domain involved in the regulation of transcriptionally active chromatin in eucaryotes, it seems possible that this specific cleavage of histone H3 is related to the host cell transcription shutoff reported for several picornaviruses.
Intranasal interleukin-12 treatment for protection against respiratory infection with methicillin-resistant <i>Staphylococcus aureus</i>. (INC7P.413) (2014)

Abstract Methicillin-resistant Staphylococcus aureus (MRSA) represents the most common pathogen associated with nosocomial pneumonia. In the present study, the role of interleukin-12 (IL-12) in inducing protective immunity in the lungs against intranasal infection of mice with MRSA was investigated. It was found that IL-12-deficient mice showed a lower survival rate, a higher bacterial burden in both the lung and spleen, and a lower level of interferon gamma (IFN-γ) in the lung than wild-type (WT) mice. These effects were completely reversed by replacement therapy with recombinant IL-12. Furthermore, exogenous IL-12 treatment of WT mice 24 h before intranasal infection with a lethal dose of MRSA significantly improved bacterial clearance and resulted in protection from death. These IL-12 treated-mice had a greater number of the lung natural killer (NK) cells and neutrophils, and had higher levels of IFN-γ in the lung and serum compared to control mice. The majority of IFN-γ-producing cells detected in IL-12-treated mice were NK cells. IL-12-induced protection against MRSA infection was abolished in NK cell-depleted, IFN-γ deficient, and MIIG mice. In addition, we found that combination therapy with linezolid and IL-12 following intranasal infection with MRSA significantly increased survival compared to mice receiving linezolid or IL-12 alone. Our results indicate that IL-12 can play an important role in protection against MRSA infection.
Coping with the Subjectivity of Human Judgements in MT Quality Estimation (2013)

Supervised approaches to NLP tasks rely on high-quality data annotations, which typically result from expensive manual labelling procedures. For some tasks, however, the subjectivity of human judgements might reduce the usefulness of the annotation for real-world applications. In Machine Translation (MT) Quality Estimation (QE), for instance, using humanannotated data to train a binary classifier that discriminates between good (useful for a post-editor) and bad translations is not trivial. Focusing on this binary task, we show that subjective human judgements can be effectively replaced with an automatic annotation procedure. To this aim, we compare binary classifiers trained on different data: the human-annotated dataset from the 7th Workshop on Statistical Machine Translation (WMT-12), and an automatically labelled version of the same corpus. Our results show that human labels are less suitable for the task. 1
A compact, high-performance HDTV camera with four-CCD chips (1995)

A compact, high-performance and yet less-expensive camera is urgently needed to create more diverse and flexible HDTV program productions. In order to meet the demand, we propose a completely new image acquisition system with four CCDs, two CCDs for green light, one for red, and the other for blue. The major purpose of our system is to obtain high-quality pictures with less pixel-number CCDs. The reduction in the number of pixels results in wider dynamic range, higher aperture ratio and low cost. The resolution power is secured by adding one more CCD to the conventional three-CCD system. We succeeded in improving the resolution by introducing spatial pixel offset imaging, in which the two G-CCDs are aligned by one-half pitch of a pixel and one of them is aligned with the R-CCD and the other with the B-CCD. This new method has two major advantages: it prevents resolution degradation caused by chromatic aberration and improves the resolution of colored signals over a wide range. The prototype camera has fully satisfied HDTV quality requirements: limiting resolution 1200 TV lines, sensitivity F5 at 2000 lux, dynamic range 500%, SNR 52 dB.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Robustness and precision of an automatic marker detection algorithm for online prostate daily targeting using a standard V‐EPID (2003)

An algorithm for the daily localization of the prostate using implanted markers and a standard video-based electronic portal imaging device (V-EPID) has been tested. Prior to planning, three gold markers were implanted in the prostate of seven patients. The clinical images were acquired with a BeamViewPlus 2.1 V-EPID for each field during the normal course radiotherapy treatment and are used off-line to determine the ability of the automatic marker detection algorithm to adequately and consistently detect the markers. Clinical images were obtained with various dose levels from ranging 2.5 to 75 MU. The algorithm is based on marker attenuation characterization in the portal image and spatial distribution. A total of 1182 clinical images were taken. The results show an average efficiency of 93% for the markers detected individually and 85% for the group of markers. This algorithm accomplishes the detection and validation in 0.20-0.40 s. When the center of mass of the group of implanted markers is used, then all displacements can be corrected to within 1.0 mm in 84% of the cases and within 1.5 mm in 97% of cases. The standard video-based EPID tested provides excellent marker detection capability even with low dose levels. The V-EPID can be used successfully with radiopaque markers and the automatic detection algorithm to track and correct the daily setup deviations due to organ motions.
Yeast carboxypeptidase Y vacuolar targeting signal is defined by four propeptide amino acids. (1990)

The amino-terminal propeptide of carboxypeptidase Y (CPY) is necessary and sufficient for targeting this glycoprotein to the vacuole of Saccharomyces cerevisiae. A 16 amino acid stretch of the propeptide was subjected to region-directed mutagenesis using randomized oligonucleotides. Mutations altering any of four contiguous amino acids, Gln-Arg-Pro-Leu, resulted in secretion of the encoded CPY precursor (proCPY), demonstrating that these residues form the core of the vacuolar targeting signal. Cells that simultaneously synthesize both wild-type and sorting-defective forms of proCPY efficiently sort and deliver only the wild-type molecule to the vacuole. These results indicate that the PRC1 missorting mutations are cis-dominant, implying that the mutant forms of proCPY are secreted as a consequence of failing to interact with the sorting apparatus, rather than a general poisoning of the vacuolar protein targeting system.
IP security impact on system performance in a distributed real-time environment (2003)

Information security in Naval shipboard platforms is becoming increasingly important with the move towards distributed computing, increased automation, and Commercial Off The Shelf (COTS) systems. Additionally, there are hard real-time requirements that must be met in a combat system, which is a critical component of the total shipboard platform. Information security services and real-time services are sometimes required simultaneously. However the real-time requirements and the security requirements conflict with one another. NSWC-DD has initiated testing of a security enhancement for the Internet Protocol, IP Security (IPSEC) in a distributed real-time environment. This paper provides a brief overview how IPSEC may be used in the platform of interest and the impact of implementing IPSEC within the kernel of the workstation operating system.
Hurler-like Phenotype (2001)

The described methodology distinguishes between patients and controls with samples that are sufficiently stable to be mailed to the testing laboratory.
Genetically Encoded Fluorescent RNA Sensor for Ratiometric Imaging of MicroRNA in Living Tumor Cells (2017)

Light-up RNA aptamers are valuable tools for fluorescence imaging of RNA in living cells and thus for elucidating RNA functions and dynamics. However, no light-up RNA sensor has been reported for imaging of microRNAs (miRs) in mammalian cells. We report a novel genetically encoded RNA sensor for fluorescent imaging of miRs in living tumor cells using a light-up RNA aptamer that binds to sulforhodamine and separates it from a conjugated contact quencher. On the basis of the structural switching mechanism for molecular beacon, we show that the RNA sensor activates high-contrast fluorescence from the sulforhodamine-quencher conjugate when its stem-loop responsive motif hybridizes with target miR. The RNA sensor can be stably expressed within a designed tRNA scaffold in tumor cells and deliver light-up response to miR target. We also realize the RNA sensor for dual-emission, ratiometric imaging by coexpression of RNA sensor with GFP, enabling quantitative studies of target miR in living cells. Our design may provide a new paradigm for developing robust, sensitive light-up RNA sensors for RNA imaging applications.
Quasi-static scheduling for multiprocessor DSP (1991)

Scheduling strategies for a multiprocessor DSP (digital signal processor) are classified into four types: fully dynamic, static-assignment, self-timed, and fully static. The concept of static scheduling (self-timed or fully static) is extended to handle nondeterministic actors in the proposed quasi-static scheduling. Quasi-static scheduling minimizes run-time overhead with increased compilation complexity, and is thus adequate for signal processing applications. The proposed scheme is applicable to the dynamic (static-assignment) scheduling strategy as well as to static (self-timed) scheduling.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Analysis and Comparative Assessment of Different Process Technologies for Manufacturing Polymer Micro-Elements (2012)

Abstract:Within the scope of the paper, three different process technologies for manufacturing polymer micro-elements are comparatively analyzed. First the different methods of ultrasonic plasticising and direct injection, expansion-injection-moulding and injection moulding in thermally low conductive mould materials are briefly introduced and their processing characteristics are explained. A comparison and a benchmark of these three technologies are made using an identical micro-mould and the same polymer. In order to verify their suitability for the production of polymer micro-elements, downscaled Campus tensile bars were produced (scale 1:16) and tested regarding their mechanical properties on polypropylene. Furthermore the morphology was investigated. It turns out that all methods can be utilized to produce polymer micro-elements. Only the components manufactured by the ultrasonic plasticising and direct injection show significantly lower mechanical properties in comparison to the other two methods. This is due among other things ascribable to the detected lower degree of crystallinity.
Facile synthesis of 2'-deoxy-3'-keto- and 2'-deoxypseudouridine derivatives and analogues. Palladium(II)-mediated coupling reactions of furanoid glycals (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFacile synthesis of 2'-deoxy-3'-keto- and 2'-deoxypseudouridine derivatives and analogues. Palladium(II)-mediated coupling reactions of furanoid glycalsJane Chi Ya Cheng, Uli Hacksell, and G. Doyle Daves Jr.Cite this: J. Org. Chem. 1986, 51, 16, 3093–3098Publication Date (Print):August 1, 1986Publication History Published online1 May 2002Published inissue 1 August 1986https://pubs.acs.org/doi/10.1021/jo00366a003https://doi.org/10.1021/jo00366a003research-articleACS PublicationsRequest reuse permissionsArticle Views522Altmetric-Citations44LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
d-Tyrosyl-tRNATyr Metabolism inSaccharomyces cerevisiae (2000)

The Saccharomyces cerevisiae YDL219w (DTD1) gene, which codes for an amino acid sequence sharing 34% identity with the Escherichia coli D-Tyr-tRNA(Tyr) deacylase, was cloned, and its product was functionally characterized. Overexpression in the yeast of the DTD1 gene from a multicopy plasmid increased D-Tyr-tRNA(Tyr) deacylase activity in crude extracts by two orders of magnitude. Upon disruption of the chromosomal gene, deacylase activity was decreased by more than 90%, and the sensitivity to D-tyrosine of the growth of S. cerevisiae was exacerbated. The toxicity of D-tyrosine was also enhanced under conditions of nitrogen starvation, which stimulate the uptake of D-amino acids. In relation with these behaviors, the capacity of purified S. cerevisiae tyrosyl-tRNA synthetase to produce D-Tyr-tRNA(Tyr) could be shown. Finally, the phylogenetic distribution of genes homologous to DTD1 was examined in connection with L-tyrosine prototrophy or auxotrophy. In the auxotrophs, DTD1-like genes are systematically absent. In the prototrophs, the putative occurrence of a deacylase is variable. It possibly depends on the L-tyrosine anabolic pathway adopted by the cell.
Investigations of a flat-panel detector for quality assurance measurements in ion beam therapy (2011)

Increased accuracy in radiation delivery to a patient provided by scanning particle beams leads to high demands on quality assurance (QA). To meet the requirements, an extensive quality assurance programme has been implemented at the Heidelberg Ion Beam Therapy Center. Currently, high-resolution radiographic films are used for beam spot position measurements and homogeneity measurements for scanned fields. However, given that using this film type is time and equipment demanding, considerations have been made to replace the radiographic films in QA by another appropriate device. In this study, the suitability of the flat-panel detector RID 256 L based on amorphous silicon was investigated as an alternative method. The currently used radiographic films were taken as a reference. Investigations were carried out for proton and carbon ion beams. The detectors were irradiated simultaneously to allow for a direct comparison. The beam parameters (e.g. energy, focus, position) currently used in the daily QA procedures were applied. Evaluation of the measurements was performed using newly implemented automatic routines. The results for the flat-panel detector were compared to the standard radiographic films. Additionally, a field with intentionally decreased homogeneity was applied to test the detector's sensitivities toward possible incorrect scan parameters. For the beam position analyses, the flat-panel detector results showed good agreement with radiographic films. For both detector types, deviations between measured and planned spot distances were found to be below 1% (1 mm). In homogeneously irradiated fields, the flat-panel detector showed a better dose response homogeneity than the currently used radiographic film. Furthermore, the flat-panel detector is sensitive to field irregularities. The flat-panel detector was found to be an adequate replacement for the radiographic film in QA measurements. In addition, it saves time and equipment because no post-exposure treatment and no developer and darkroom facilities are needed.
Blue Electroluminescence from Poly(2,5-diheptyloxy-1,4-phenylene) (1995)

Poly(2,5-diheptyloxy-1,4-phenylene) has been prepared by oxidative coupling of p -diheptyloxybenzene using iron (III) chloride as catalyst in chloroform at room temperature. The polymer obtained was completely soluble in chloroform. An electroluminescence diode based on this polymer emitting blue light was fabricated, and its properties are discussed in terms of the band structure of the diode.
Simulation of hearing impairment based on the Fourier time transformation (2002)

A signal processing system was designed to simulate hearing impairment for normal hearing listeners. Typical consequences of sensorineural hearing loss are an elevated threshold in quiet, abnormal growth of loudness ('recruitment') and reduced spectral and temporal resolution. However, the just noticable difference (jnd) in intensity is unaffected. Based on an aurally adequate time-frequency representation, these effects can be simulated by intensity quantization and frequency dependent dynamic level expansion. The Fourier time transformation (FTT) was used for analysis of the time signal and the inverse FTT for resynthesis of the modified complex spectra. Input-output functions used for level expansion are calculated from the audiogram and a categorical loudness scaling procedure. Hearing experiments were carried out to find the appropriate quantization step and to simulate intensity jnd's of normal and hearing impaired listeners. The proposed processing scheme will be used to improve the design and fitting of hearing aids.