gebhart/patrepeval huggingface dataset:
Abstract A129: Ablation of neuropilin 1 from glioma associated macrophages and microglia slows tumor progression (2016)

Abstract Gliomas are the most commonly diagnosed primary tumors of the central nervous system (CNS). Median times of survival are dismal regardless of the treatment approach, underlying the need to develop more effective therapies. Modulation of the immune system is a promising strategy as innate and adaptive immunity play important roles in cancer progression. Glioma associated microglia and macrophages (GAMs) can comprise over 30% of the cells in glioma biopsies. Gliomas secrete cytokines that suppress the anti-tumorigenic properties of GAMs, causing them to secrete factors that support the tumor's spread and growth. Neuropilin 1 (Nrp1) is a transmembrane receptor that in mice both amplifies pro-angiogenic signaling in the tumor microenvironment and affects behavior of innate immune cells. Using a Cre-lox system, we generated mice that lack expression of Nrp1 in GAMs. We demonstrate, using an in vivo orthotopic glioma model, that tumors in mice with Nrp1-deficient GAMs exhibit less vascularity, grow at a slower pace, and are populated by increased numbers of anti-tumorigenic GAMs. Moreover, glioma survival times in mice with Nrp1-deficient GAMs were significantly longer. Treating wild-type mice with a small molecule inhibitor of Nrp1's b1 domain, EG00229, which we show here is selective for Nrp1 over Nrp2, yielded an identical outcome. Moreover, transplanting bone marrow from mice with Nrp1-deficient macrophages to wild type recipient mice led to reductions in tumor growth, al-be-it not to the extent seen in knockout mice. Nrp1-deficient or EG00229-treated wild-type microglia exhibited a shift towards anti-tumorigenicity as evident by altered inflammatory marker profiles in vivo and decreased SMAD2/3 activation when conditioned in the presence of glioma-derived factors. These results provide support for the proposal that pharmacological inhibition of Nrp1 constitutes a potential strategy for suppressing glioma progression. Citation Format: Jeremy T. Miyauchi, Danling Chen, Matthew Choi, Jillian Nissen, Kenneth Shroyer, David Selwood, Stella E. Tsirka. Ablation of neuropilin 1 from glioma associated macrophages and microglia slows tumor progression [abstract]. In: Proceedings of the Second CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference: Translating Science into Survival; 2016 Sept 25-28; New York, NY. Philadelphia (PA): AACR; Cancer Immunol Res 2016;4(11 Suppl):Abstract nr A129.
Bacteriophage Active Against Virulent Mycobacterium tuberculosis—I. Isolation and Activity (1954)

Bacteriophage Active Against Virulent Mycobacterium tuberculosis—I. Isolation and Activity Seymour Froman, Drake W. Will, and Emil Bogen CopyRight https://doi.org/10.2105/AJPH.44.10.1326 Published Online: August 29, 2011
Characterization of Growth and Acid Formation in a <i>Bacillus subtilis</i> Pyruvate Kinase Mutant (2000)

Based on measurements and theoretical analyses, we identified deletion of pyruvate kinase (PYK) activity as a possible route for elimination of acid formation in Bacillus subtilis cultures grown on glucose minimal media. Evidence consistent with the attenuation of PYK flux has come from metabolic flux calculations, metabolic pool and enzymatic activity measurements, and a series of nuclear magnetic resonance experiments, all suggesting a nearly complete inhibition of PYK activity for glucose-citrate fed cultures in which the amount of acid formation was nearly zero. In this paper, we report the construction and characterization of a pyk mutant of B. subtilis. Our results demonstrate an almost complete elimination of acid production in cultures of the pyk mutant in glucose minimal medium. The substantial reduction in acid production is accompanied by increased CO(2) production and a reduced rate of growth. Metabolic analysis indicated a dramatic increase in intracellular pools of phosphoenolpyruvate (PEP) and glucose-6-P in the pyk mutant. The high concentrations of PEP and glucose-6-P could explain the decreased growth rate of the mutant. The substantial accumulation of PEP does not occur in Escherichia coli pyk mutants. The very high concentration of PEP which accumulates in the B. subtilis pyk mutant could be exploited for production of various aromatics.
A comparison of three sequences of methods for teaching the solving of simultaneous linear equations in ninth grade algebra / (1975)

To Larry Elbrink and Fred Ruland, for every help
Structural and functional quantitative susceptibility mapping from standard fMRI studies (2016)

Standard functional MRI (fMRI), which includes resting-state or paradigm-driven designs, is widely used in studies of brain function, aging, and disease. These fMRI studies typically use two-dimensional gradient echo-planar imaging, which inherently contains phase data that enables quantitative susceptibility mapping (QSM). This work focuses on the dual value of QSM within fMRI studies, by providing both a localized analysis of functional changes in activated tissue, and iron-sensitive structural maps in deep grey matter (DGM). Using a visual paradigm fMRI study on healthy volunteers at clinical (1.5 T) and high field strength (4.7 T), we perform functional analysis of magnitude and QSM time series, and at the same time harness structural QSM of iron-rich DGM, including globus pallidus, putamen, caudate head, substantia nigra, and red nucleus. The effects of fMRI spatial resolution and time series variation on structural DGM QSM are investigated. Our results indicate that structural DGM QSM is feasible within existing fMRI studies, provided that the voxel dimensions are equal to or less than 3 mm, with higher resolutions preferred. The mean DGM QSM values were about 40 to 220 ppb, while the interquartile ranges of the DGM QSM time series varied from about 3 to 9 ppb, depending on structure and resolution. In contrast, the peak voxel functional QSM (fQSM) changes in activated visual cortex ranged from about -10 to -30 ppb, and functional clusters were consistently smaller on QSM than magnitude fMRI. Mean-level DGM QSM of the time series was successfully extracted in all cases, while fQSM results were more prone to residual background fields and showed less functional change compared with standard magnitude fMRI. Under the conditions prescribed, standard fMRI studies may be used for robust mean-level DGM QSM, enabling study of DGM iron accumulation, in addition to functional analysis. Copyright © 2016 John Wiley & Sons, Ltd.
Research Trends In Select Science Faculties Of University Of Jammu. (2014)

The study attempts to analyze and report research trends in various subject fields of the faculty of Sciences, Life Sciences and Mathematical Science of University of Jammu. The analysis is based on the data gathered from SCOPUS as on March-May, 2011. The data gathered were meticulously analysed to depict research trends in different Departments and Subject areas viz: collaboration at various levels, authorship patterns, and citation profile. The findings reveal that although the faculties under study have witnessed potential growth in terms of research output. However, several departments are still lagging behind in terms of productivity and quality research, which is evident from low research output and citation count received by the publications. Current study is confined to 1237 research contributions that were published during 39 years from (1972 to May, 2011), by the 15 departments under the faculty of Sciences, Life Sciences and Mathematical Sciences of University of Jammu indexed by SCOPUS. The study is beneficial to highlight potential areas of research and will act as a tool for addressing problems at research front in those subject areas where research output is very meagre.
Vehicle localization in outdoor woodland environments with sensor fault detection (2008)

This paper describes a 2D localization method for a differential drive mobile vehicle on real forested paths. The mobile vehicle is equipped with two rotary encoders, Crossbow’s NAV420CA Inertial Measurement Unit (IMU) and a NAVCOM SF-2050M GPS receiver (used in StarFire-DGPS dual mode). Loosely-coupled multisensor fusion and sensor fault detection issues are discussed as well. An extended Kalman Filter (EKF) is used for sensor fusion estimation where a GPS noise pre-filter is used to avoid introducing biased GPS data (affected by multi-path). Normalized Innovation Squared (NIS) tests are performed when a GPS measurement is incorporated to reject GPS data outliers and keep the consistency of the filter. Finally, experimental results show the performance of the localization system compared to a previously measured ground truth.
Formation of Titanium Nitride Layers and Composite Layers under Glow Discharge Conditions (1990)

By applying a glow discharge in a gaseous mixture composed of TiCI 4 , H 2 , and N 2 it is possible to produce titanium nitride layers or – if the process is conducted in two stages differing in the atmospheres used – composite layers, e.g. a nitrided layer covered by a titanium nitride layer. Electric activation of the gaseous medium and of the surface under treatment makes it possible to reduce the treatment temperature to ∼600°C.An installation is described for producing titanium nitride layers and composite layers and the results of structural examinations and wear tests performed on these layers are presented.
Secure graphical data storage by full spectrum image coding (2006)

Full Spectrum coding is a method of providing a picture with a machine readable code image. The transparency and robustness of the code can be influenced by the embedding parameters, according to the intended application (e.g. robust or fragile marking). The code image contains hidden information, identifying the document in some way. In principle, it can be any binary pattern or grey-scale picture. Alternatively, it may be desirable to encode (binary) data, e.g. ID numbers or (biometric) templates. Such data should be transformed into a code image suitable for the proposed kind of embedding. In the presented implementation, the code image contains a binary block structure, similar to a 2-dimensional (bar) code. Even in the presence of noise, this code can be extracted from the magnitude spectrum of the captured image by iterated down-sampling. Full Spectrum is well-suited for application to printed documents. It survives graphical processes (halftone screening, printing, digitizing) and the reconstructed code image is invariant to shifting and robust to cropping. A technique is presented to perform registration for rotation and scaling of the captured image with respect to the original. The approach is to embed a marking signal based on perfect correlation sequences in the radial-polar representation of the code image. In this domain, the rotation angle and (under certain conditions) the scale factor, can be determined by linear cross-correlation. Additionally, techniques are proposed to obtain resistance to more general distortions.
IMbrave150: A randomized phase III study of 1L atezolizumab plus bevacizumab vs sorafenib in locally advanced or metastatic hepatocellular carcinoma. (2018)

TPS4141 Background: Hepatocellular carcinoma (HCC) is a lethal disease with the highest mortality-to-incidence ratio of any solid tumor. The current standard of care for 1L treatment of patients (pts) with locally advanced or metastatic HCC is sorafenib (sor), a multikinase inhibitor. Single-agent treatment involving inhibition of PD-L1/PD-1 immune checkpoint or VEGF has shown modest activity in HCC. Evidence from a Phase I study (Stein ASCO 2018, submitted) in HCC supports a strong scientific rationale for combining atezolizumab (atezo; anti–PD-L1) with bevacizumab (bev; anti-VEGF) to achieve greater clinical benefit. In addition to its anti-angiogenic activity, bev may have immunomodulatory effects in the tumor microenvironment (increased DC maturation, enhanced T-cell infiltration, reduced MDSCs and Tregs in tumors) that can potentially increase the efficacy of atezo in inhibiting PD-L1/PD-1 signaling and restoring anti-tumor T-cell activity. Methods: IMbrave150 (YO40245) is a Phase III, open-label, multicenter, randomized study to evaluate atezo + bev vs sor in pts with locally advanced or metastatic and/or unresectable HCC. Eligible pts will be naive to prior systemic therapy for HCC, have ≥ 1 measurable untreated lesion (per RECIST v1.1), Child-Pugh class A liver function and ECOG PS 0/1. Pts with bleeding or high risk for bleeding with untreated varices will be excluded. Randomization will be stratified by region (Asia [excluding Japan] vs rest of world), macrovascular invasion and/or extrahepatic spread (presence vs absence), baseline α-fetoprotein level ( < 400 vs ≥ 400 ng/mL) and ECOG PS (0 vs 1). Pts will be randomized 2:1 to receive atezo (1200 mg) plus bev (15 mg/kg) IV Q3W or sor (400 mg) PO BID until loss of clinical benefit or unacceptable toxicity. No crossover will be allowed. Co-primary and secondary efficacy endpoints are listed in Table. ≈ 480 pts are planned to be enrolled globally. Clinical trial information: NCT03434379.Efficacy endpoints. Co-primary ORR (investigator [INV]-assessed per RECIST v1.1), OS Secondary PFS, DOR, TTP (INV-assessed per RECIST v1.1) ORR, PFS, DOR, TTP (independent review facility (IRF)-assessed per RECIST v1.1) ORR, PFS, DOR, TTP (IRF-assessed per HCC mRECIST)
Survival of Cholinergic Forebrain Neurons in Developing p75 <sup>NGFR</sup> -Deficient Mice (1996)

The functions of the low-affinity p75 nerve growth factor receptor (p75(NGFR)) in the central nervous system were explored in vivo. In normal mice, approximately 25 percent of the cholinergic basal forebrain neurons did not express TrkA and died between postnatal day 6 and 15. This loss did not occur in p75(NGFR)-deficient mice or in normal mice systemically injected with a p75(NGFR)-inhibiting peptide. Control, but not p75(NGFR)-deficient, mice also had fewer cholinergic striatal interneurons. Apparently, p75(NGFR) mediates apoptosis of these developing neurons in the absence of TrkA, and modulation of p75(NGFR) can promote neuronal survival. Cholinergic basal forebrain neurons are involved in learning and memory.
High performance conducting polymer supported oxygen reduction catalysts (1998)

Z. Qi and P. G. Pickup, Chem. Commun., 1998, 2299 DOI: 10.1039/A805322G
Diverse chemotypes disrupt ion homeostasis in the malaria parasite (2014)

The antimalarial spiroindolones disrupt Plasmodium falciparum Na(+) regulation and induce an alkalinization of the parasite cytosol. It has been proposed that they do so by inhibiting PfATP4, a parasite plasma membrane P-type ATPase postulated to export Na(+) and import H(+) equivalents. Here, we screened the 400 antiplasmodial compounds of the open access 'Malaria Box' for their effects on parasite ion regulation. Twenty eight compounds affected parasite Na(+) and pH regulation in a manner consistent with PfATP4 inhibition. Six of these, with chemically diverse structures, were selected for further analysis. All six showed reduced antiplasmodial activity against spiroindolone-resistant parasites carrying mutations in pfatp4. We exposed parasites to incrementally increasing concentrations of two of the six compounds and in both cases obtained resistant parasites with mutations in pfatp4. The finding that diverse chemotypes have an apparently similar mechanism of action indicates that PfATP4 may be a significant Achilles' heel for the parasite.
A fully integrated sensor interface chip (1999)

A single-chip sensor signal conditioning system is described. The chip contains two 20-bit sigma-delta A-D converters. The main ADC has a rail-to-rail input buffer and PGA. There is a 12-bit DAC and current sources for sensor excitation and circuitry for sensor fault detection. An 8052 microcontroller core is provided for processing the ADC outputs. There is 640 bytes of user flash memory and 8k bytes of program flash. Clocking is from a 32kHz watch crystal oscillator. An on-chip PLL multiplies up this frequency to provide programmable clocks for the microcontroller. The die area is 17mm2on a 0.5µm TPTM flash memory process. Power consumption is 10mW at 3V.
Common Remote Authentication Dial In User Service (RADIUS) Implementation Issues and Suggested Fixes (2007)

This document describes common issues seen in RADIUS implementations
and suggests some fixes. Where applicable, ambiguities and errors in
previous RADIUS specifications are clarified.
Laser-induced chemical vapor deposition of polycrystalline Si from SiCl4 (1980)

Polycrystalline Si films with average grain sizes of ∼8 μm have been grown by laser-induced chemical vapor deposition from SiCl4. A cw CO2 laser operated at 10.6 μm was used to provide local heating of quartz substrates in an otherwise cool reactor to initiate the endothermic decomposition reaction. Deposition rates of 5.1 μm/min were obtained for films grown at an incident laser power of 18.9 W, resulting in sharply defined mesa structures due to the occurrence of the reverse reaction, etching of free Si, at cooler regions of the substrate surface closer to the edge of the 6-mm irradiated zone. The diameter of the mesas was 1.4 mm with thicknesses up to 26 μm. Three modes of film growth, depending on the incident laser power, were observed.
Analysis of Reset Control Systems Consisting of a FORE and Second-Order Loop1 (2001)

Reset controllers consist of two parts—a linear compensator and a reset element. The linear compensator is designed, in the usual ways, to meet all closed-loop performance specifications while relaxing the overshoot constraint. Then, the reset element is chosen to meet this remaining step-response specification. In this paper, we consider the case when such linear compensation results in a second-order (loop) transfer function and where a first-order reset element (FORE) is employed. We analyze the closed-loop reset control system addressing performance issues such as stability, steady-state response, and transient performance.
Chlorophyll Fluorescence Imaging of the Chlorophyll Fluorescence Induction Phenomenon for Plant Health Monitoring (2009)

Chlorophyll fluorescence imaging is useful as a non-destructive method for evaluating photosynthetic function of plants. A dynamic change in chlorophyll fluorescence intensity, known as the chlorophyll fluorescence induction phenomenon, can be observed by illuminating a dark-adapted green leaf with a stable intensity excitation light. The time course of the chlorophyll fluorescence intensity during this phenomenon, presented as an induction curve, varies depending on the health of the plant. Imaging of the chlorophyll fluorescence induction phenomenon may be used to monitor the health status of plants. In this review, we introduce studies on our chlorophyll fluorescence imaging system for plant health monitoring of tomato crops grown in a greenhouse. We first developed a prototype of the imaging system to confirm performance on detection of artificially induced light stress in a single leaf and whole plant. Based on the successful detection of photosynthetic dysfunction caused by light stress using the prototype, we applied our chlorophyll fluorescence imaging system to measurements of the chlorophyll fluorescence induction curves of tomato crops grown in a semi-commercial greenhouse. Upon comparing the induction curves of 20 tomato crops planted on a north-south lane in the greenhouse, we found two plants with unique induction curve patterns. One of these two plants showed visible symptoms of physiological dysfunction 7 days after measurement. Thus, our chlorophyll fluorescence imaging system appears to be a useful tool for plant health monitoring in horticultural production.
Optimum ArFi laser bandwidth for 10nm node logic imaging performance (2015)

Lithography process window (PW) and CD uniformity (CDU) requirements are being challenged with scaling across all device types. Aggressive PW and yield specifications put tight requirements on scanner performance, especially on focus budgets resulting in complicated systems for focus control. In this study, an imec N10 Logic-type test vehicle was used to investigate the E95 bandwidth impact on six different Metal 1 Logic features. The imaging metrics that track the impact of light source E95 bandwidth on performance of hot spots are: process window (PW), line width roughness (LWR), and local critical dimension uniformity (LCDU). In the first section of this study, the impact of increasing E95 bandwidth was investigated to observe the lithographic process control response of the specified logic features. In the second section, a preliminary assessment of the impact of lower E95 bandwidth was performed. The impact of lower E95 bandwidth on local intensity variability was monitored through the CDU of line end features and the LWR power spectral density (PSD) of line/space patterns. The investigation found that the imec N10 test vehicle (with OPC optimized for standard E95 bandwidth of300fm) features exposed at 200fm showed pattern specific responses, suggesting areas of potential interest for further investigation.
Engineering of human vascular aortic tissue based on a xenogeneic starter matrix. (2000)

Porcine vessels were acellularized and consecutively fully repopulated with human EC and myofibroblasts. This approach may eventually lead to the engineering of vessels immunologically acceptable to the host using a relatively short preparation period of 2-3 weeks. We expect matrix turnover in vivo leading to a gradual assimilation of the matrix structure by the host mediated by the hosts autologous cells.
Improving instructional practice: An action research study of the integration of technology into a grade four/five social studies curriculum (2001)

de reproduction sur papier ou sur format electronique.
Development of a plasma sprayed ceramic gas path seal for high pressure turbine applications (1978)

Development of the plasma sprayed graded, layered ZrO2/CoCrAlY seal system for gas turbine engine blade tip seal application up to 1589 K (2400 F) surface temperature was continued. Methods of improvement of the cyclic thermal shock resistance of the sprayed zirconia seal system were investigated. The most promising method, reduction of the ceramic thickness and metallic substrate stiffness were selected based upon potential and feasibility. Specimens were fabricated and experimentally evaluated to: (1) substantiate the capacity of the geometry changes to reduce operating stresses in the sprayed structure; and (2) define the abradability, erosion, thermal shock and physical property characteristic for the sprayed ceramic seal system. Thermal stress analysis was performed and correlated with thermal shock test results.
Interactions of Carbon Dioxide with Liquid Fluorocarbons (2003)

The interactions of carbon dioxide with liquid fluorinated and hydrogenated hydrocarbons, perfluoro-n-hexane and n-hexane, are investigated by computer simulation. Conformational and structural properties of the liquid phases were obtained applying the molecular dynamics method using flexible, all-atom force fields containing electrostatic charges. It was verified that spontaneous cavities are larger and more easily formed in the fluorocarbon, corresponding to smaller free energies of cavity formation, than in the equivalent hydrocarbon. These facts do not explain the high solubility of carbon dioxide compared to that of other gases, a behavior resulting from differences in solute−solvent interactions. The chemical potential at infinite dilution and the solubility of carbon dioxide and oxygen in the solvents were determined from the simulation runs by the method of test-particle insertion. It is demonstrated that electrostatics play a minor role in the forces between carbon dioxide and both alkanes and perfluoroalkanes, which are mainly governed by dispersion terms. No evidence of a particular affinity of carbon dioxide for perfluorinated liquids was found either from the results of the present or from analysis of literature data on gas solubility.