gebhart/patrepeval huggingface dataset:
Multi-signal flow graphs: a novel approach for system testability analysis and fault diagnosis (1995)

In this paper, we present a comprehensive methodology for a formal, but intuitive, cause-effect dependency modeling using multi-signal directed graphs that correspond closely to hierarchical system schematics and develop diagnostic strategies to isolate faults in the shortest possible time without making the unrealistic single fault assumption. A key feature of our methodology is that our models lend naturally to real-world necessities, such as system integration and hierarchical troubleshooting.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Construction of a Functional CMP-Sialic Acid Biosynthesis Pathway in Arabidopsis (2008)

Previous studies have reported that plants contain negligible amounts of free or protein-bound N-acetylneuraminic acid (Neu5Ac). This is a major disadvantage for the use of plants as a biopharmaceutical expression system, since N-glycans with terminal Neu5Ac residues are important for the biological activities and half-lives of recombinant therapeutic glycoproteins in humans. For the synthesis of Neu5Ac-containing N-glycans, plants have to acquire the ability to synthesize Neu5Ac and its nucleotide-activated derivative, cytidine monophospho-N-acetylneuraminic acid. In this study, we have generated transgenic Arabidopsis (Arabidopsis thaliana) plants expressing three key enzymes of the mammalian Neu5Ac biosynthesis pathway: UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, N-acetylneuraminic acid phosphate synthase, and CMP-N-acetylneuraminic acid synthetase. Simultaneous expression of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase and N-acetylneuraminic acid phosphate synthase resulted in the generation of significant Neu5Ac amounts (1,275 nmol g(-1) fresh weight in leaves) in planta, which could be further converted to cytidine monophospho-N-acetylneuraminic acid (2.4 nmol g(-1) fresh weight in leaves) by coexpression of CMP-N-acetylneuraminic acid synthetase. These findings are a major step toward the production of Neu5Ac-containing glycoproteins in plants.
Bi surfactant effects on ordering in GaInP grown by organometallic vapor-phase epitaxy (2000)

The effect of the isoelectronic surfactant Bi on surface structure and ordering has been studied for GaInP semiconductor alloys grown by organometallic vapor-phase epitaxy. A small amount of Bi (trimethylbismuth) added during growth is found to result in disordering for layers grown using conditions that would otherwise produce highly ordered materials. An order of magnitude increase in the step velocity was observed by atomic-force microscopy. Bi completely eliminates three-dimensional islands on the singular (001) surface.
Production of extracellular nucleic acids by genetically altered bacteria in aquatic-environment microcosms (1989)

The factors which affect the production of extracellular DNA by genetically altered strains of Escherichia coli, Pseudomonas aeruginosa, Pseudomonas cepacia, and Bradyrhizobium japonicum in aquatic environments were investigated. Cellular nucleic acids were labeled in vivo by incubation with [3H]thymidine or [3H]adenine, and production of extracellular DNA in marine waters, artificial seawater, or minimal salts media was determined by detecting radiolabeled macromolecules in incubation filtrates. The presence or absence of the ambient microbial community had little effect on the production of extracellular DNA. Three of four organisms produced the greatest amounts of extracellular nucleic acids when incubated in low-salinity media (2% artificial seawater) rather than high-salinity media (10 to 50% artificial seawater). The greatest production of extracellular nucleic acids by P. cepacia occurred at pH 7 and 37 degrees C, suggesting that extracellular-DNA production may be a normal physiologic function of the cell. Incubation of labeled P. cepacia cells in water from Bimini Harbor, Bahamas, resulted in labeling of macromolecules of the ambient microbial population. Collectively these results indicate that (i) extracellular-DNA production by genetically altered bacteria released into aquatic environments is more strongly influenced by physiochemical factors than biotic factors, (ii) extracellular-DNA production rates are usually greater for organisms released in freshwater than marine environments, and (iii) ambient microbial populations can readily utilize materials released by these organisms.
Rapid and efficient fusion of phospholipid vesicles by the α-helical core of a SNARE complex in the absence of an N-terminal regulatory domain (1999)

A protease-resistant core domain of the neuronal SNARE complex consists of an alpha-helical bundle similar to the proposed fusogenic core of viral fusion proteins [Skehel, J. J. & Wiley, D. C. (1998) Cell 95, 871-874]. We find that the isolated core of a SNARE complex efficiently fuses artificial bilayers and does so faster than full length SNAREs. Unexpectedly, a dramatic increase in speed results from removal of the N-terminal domain of the t-SNARE syntaxin, which does not affect the rate of assembly of v-t SNARES. In the absence of this negative regulatory domain, the half-time for fusion of an entire population of lipid vesicles by isolated SNARE cores ( approximately 10 min) is compatible with the kinetics of fusion in many cell types.
Ambient‐cured polyesteramide‐based anticorrosive coatings from linseed oil—A sustainable resource (2005)

Abstract Ambient‐cured polyesteramide (APEA) coating resin synthesized from dihydroxy fatty amide obtained from linseed oil, a sustainable resource, and poly(styrene‐ co ‐maleic anhydride), a bifunctional acid component, was found to exhibit improved physicomechanical and anticorrosive properties. The structural elucidation of APEA resin has been carried out by FTIR, 1 H‐NMR, and 13 C‐NMR spectroscopies. The physicomechanical and chemical resistance properties were investigated by standard methods. The corrosion resistance performance was evaluated in acid, alkali, and organic solvent. The thermal behavior was studied by TGA technique. A comparative study of these properties of APEA with reported baked polyesteramide (PEA) coatings was carried out. A remarkable improvement in the drying property of APEA was observed. The APEA coatings also showed improved physicomechanical and anticorrosive properties as compared to the baked PEA coatings. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci 97: 1818–1824, 2005
Physicochemical Properties of SnO2 ‐ Sb2 O 5 Films Prepared by the Spray Pyrolysis Technique (1996)

The properties of SnO2-Sb2O5 mixed-oxide films prepared by the spray pyrolysis method were studied under different synthesis conditions. The film density, measured by profilometry and by a spectrophotometric method, was close to that reported in the literature for crystalline tin dioxide. Analysis by energy dispersive spectrometry and x-ray photo-electron spectroscopy showed that the Sb/Sn atom ratio in the films was in all cases about 2.5 times larger with respect to that in the precursor solution. Microstructural characterization by wide-angle x-ray scattering indicates that the deposits consist of large sized crystallites. The influence of the substrate temperature (T) on the average crystallite size (l) has shown that l decreases linearly with T. SEM showed that the surface of films thinner than 0.5-0.8 micron is flat with only a limited number of emerging particles.
Electrostatic Assembly of Nanoparticles and Biomacromolecules (2002)

The controlled assembly of nanoparticles in thin film form on solid supports, both as monolayers and as superlattice structures, is a problem of considerable topical interest. Among the many interactions used to program the assembly of nanoparticles, electrostatic forces are particularly interesting for many reasons. This Account deals with assembling surface-modified nanoparticles in thin film form using electrostatic interactions at the air-water interface and in thermally evaporated lipid films. The generality of the electrostatic assembly protocol is demonstrated in the immobilization of DNA and proteins in lipid films.
Sequence query processing (1994)

Many applications require the ability to manipulate sequences of data. We motivate the importance of sequence query processing, and present a framework for the optimization of sequence queries based on several novel techniques. These include query transformations, optimizations that utilize meta-data, and caching of intermediate results. We present a bottom-up algorithm that generates an efficient query evaluation plan based on cost estimates. This work also identifies a number of directions in which future research can be directed.
Photochemical removal of NpF sub 6 and PuF sub 6 from UF sub 6 gas streams (1990)

A novel photochemical method of removing reactive fluorides from UF{sub 6} gas has been discovered. This method reduces generated waste to little more than the volume of the removed impurities, minimizes loss of UF{sub 6}, and can produce a recyclable by-product, fluorine gas. In our new method, impure UF{sub 6}, is exposed to ultraviolet light which dissociates the UF{sub 6} to UF{sub 5} and fluorine atom. Impurities which chemically react with UF{sub 5} are reduced and form solid compounds easily removed from the gas while UF{sub 5} is converted back to UF{sub 6}. Proof-of-concept testing involved UF{sub 6} containing NpF{sub 6} and PuF{sub 6} with CO added as a fluorine atom scavenger. In a single photolysis step, greater than 5000-fold reduction of PuF{sub 6} was demonstrated while reducing NpF{sub 6} by more than 40-fold. This process is likely to remove corrosion and fission product fluorides that are more reactive than UF{sub 6} and has been demonstrated without an added fluorine atom scavenger by periodically removing photogenerated fluorine gas. 44 refs., 3 figs., 2 tabs.
Long-acting ACE Inhibitor-Induced Angioedema (1992)

Angioedema is a known adverse reaction of the angiotensin converting enzyme (ACE) inhibitors. Although current investigations are in progress, the exact pathogenesis of ACE inhibitor-induced angioedema is still unclear. Most cases of angioedema we have seen remitting from the short-acting ACE inhibitor, captopril, have presented with mild angioedema, controlled with antihistamines and glucocorticosteroids. In contrast, the angioedema induced by the long-acting ACE inhibitors have been serious. Our five patients developed angioedema from either lisinopril or enalapril. Three of five patients presented with severe angioedema requiring intubation, and one of these patients had a tracheostomy. One patient with a history of mild angioedema secondary to captopril subsequently required intubation for his enalapril-induced angioedema.
Model-based segmentation of the brain from 3-D MRI using active surfaces (2002)

Traditional segmentation approaches have proven inadequate when faced with the anatomical complexity and variability exhibited by biological structures such as the brain. A 3-D extension to the 'snakes' algorithm has been implemented and used to segment the brain surface from MRI image volumes of the head in an effort to investigate model-based, top-down segmentation strategies. These active surfaces allow closed surfaces of complex objects to be recovered using a priori knowledge in the form of initial conditions and applied external forces. Preliminary results suggest that active surfaces may be initialized according to a preconceived model and adaptively deformed by image data to recover the desired object surface.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
El campo ”interdisciplinario” de pedagogía social y animación sociocultural en Finlandia (2008)

La pedagogia social es una asignatura bastante nueva en Finlandia. El primer libro de texto salio a la luz en 1997 (Hamalainen y Kurki) y el primero de animacion sociocultural en 2000 (Kurki). Despues tenemos cuatro libros de texto en fines (Kurki 2002 (Persona y comunidad: sobre la pedagogia social personalizada o personalista); Kurki, Nivala y Sipila-Lahdekorpi 2006 (sobre la pedagogia social en la escuela); Kurki y Nivala y Leino 2006 (sobre la ciudadania) y Kurki 2007 (sobre la animacion sociocultaral en la tercera edad), el quinto sobre la animacion, ocio y turismo esta en preparacion (Kurki). En muchas colecciones tambien hay articulos de pedagogia social y animacion sociocultural y la Asociacion de Pedagogia Social en Finlandia (fundada en 1997) publica cada ano una coleccion de articulos en su ”libro anual”. Como Ustedes pueden ver, tenemos todavia problemas con la literatura. El problema es bastante grande porque la mayoria de los libros de pedagogia social se publican en aleman, castellano, portugues y frances y en Finlandia casi todo el discurso en el campo de la accion social y ciencias sociales es anglo-americano.
Reverse osmosis/ultrafiltration process principles (1985)

Peer reviewed: Yes
A study evaluating the efficacy and tolerability of tropisetron in combination with dexamethasone in the prevention of delayed platinum-induced nausea and emesis (1998)

Tropisetron added to dexamethasone improved control of delayed nausea on Day 3 compared with placebo. No significant differences were recorded regarding control of delayed emesis.
A PRACTICAL SYNTHETIC METHOD FOR N-METHYL-<i>o</i>-TOLUIDINE (1989)

"A PRACTICAL SYNTHETIC METHOD FOR N-METHYL-o-TOLUIDINE." Organic Preparations and Procedures International, 21(3), pp. 340–341
Bias and Temperature Dependence of Sb-Based Heterostructure Millimeter-Wave Detectors With Improved Sensitivity (2004)

Nearly lattice-matched InAs/AlSb/GaSb-based heterostructure backward diodes for zero-bias millimeter wave detection were fabricated and measured. A record-high curvature, /spl gamma/=39.1 V/sup -1/, at zero bias was measured. On-wafer sensitivity measurements from 1 to 110 GHz gave a record-high average sensitivity of 3687 V/W for zero-bias operation. Further enhancement of detector sensitivity was observed with applied dc bias, with a sensitivity of 7996 V/W obtained for a 0.9 μA bias. Extrapolating the conjugately-matched measured sensitivity suggests that 1000 V/W should be achievable at a record-high 541 GHz. The temperature dependence of detector sensitivity was evaluated from measured dc current-voltage characteristics and gave expected sensitivities ranging from 3910 V/W at 293 K to 7740 V/W at 4.2 K.
Genetics of CD33 in Alzheimer's disease and acute myeloid leukemia (2015)

The CD33 single-nucleotide polymorphism (SNP) rs3865444 has been associated with the risk of Alzheimer's disease (AD). Rs3865444 is in linkage disequilibrium with rs12459419 which has been associated with efficacy of an acute myeloid leukemia (AML) chemotherapeutic agent based on a CD33 antibody. We seek to evaluate the extent to which CD33 genetics in AD and AML can inform one another and advance human disease therapy. We have previously shown that these SNPs are associated with skipping of CD33 exon 2 in brain mRNA. Here, we report that these CD33 SNPs are associated with exon 2 skipping in leukocytes from AML patients and with a novel CD33 splice variant that retains CD33 intron 1. Each copy of the minor rs12459419T allele decreases prototypic full-length CD33 expression by ∼ 25% and decreases the AD odds ratio by ∼ 0.10. These results suggest that CD33 antagonists may be useful in reducing AD risk. CD33 inhibitors may include humanized CD33 antibodies such as lintuzumab which was safe but ineffective in AML clinical trials. Here, we report that lintuzumab downregulates cell-surface CD33 by 80% in phorbol-ester differentiated U937 cells, at concentrations as low as 10 ng/ml. Overall, we propose a model wherein a modest effect on RNA splicing is sufficient to mediate the CD33 association with AD risk and suggest the potential for an anti-CD33 antibody as an AD-relevant pharmacologic agent.
The Train Benchmark: cross-technology performance evaluation of continuous model queries (2017)

In model-driven development of safety-critical systems (like automotive, avionics or railways), well-formedness of models is repeatedly validated in order to detect design flaws as early as possible. In many industrial tools, validation rules are still often implemented by a large amount of imperative model traversal code which makes those rule implementations complicated and hard to maintain. Additionally, as models are rapidly increasing in size and complexity, efficient execution of validation rules is challenging for the currently available tools. Checking well-formedness constraints can be captured by declarative queries over graph models, while model update operations can be specified as model transformations. This paper presents a benchmark for systematically assessing the scalability of validating and revalidating well-formedness constraints over large graph models. The benchmark defines well-formedness validation scenarios in the railway domain: a metamodel, an instance model generator and a set of well-formedness constraints captured by queries, fault injection and repair operations (imitating the work of systems engineers by model transformations). The benchmark focuses on the performance of query evaluation, i.e. its execution time and memory consumption, with a particular emphasis on reevaluation. We demonstrate that the benchmark can be adopted to various technologies and query engines, including modeling tools; relational, graph and semantic databases. The Train Benchmark is available as an open-source project with continuous builds from https://github.com/FTSRG/trainbenchmark.
AtomServ Architecture: Towards Internet-scaled Service Publish, Subscription, and Discovery (2006)

With the surge of SOA-based infrastructure and applications, increasingly end users and small-medium-enterprises directly participate in the service publish and discovery across the Internet. The recent shutdown of public UDDI exposes critical problems of existing Internet-based service discovery. Hence, public service discovery becomes a central SOA issue. In this paper, we present a light weight service discovery architecture built upon widely-adopted WWW technologies and proven software architectural styles. Firstly, it provides a handy discovery facility for personal Web services providers and consumers, who would not be expected to able to use complex UDDI specifications with dedicated endpoint computing capability. Secondly, it widens the adoption of service discovery by allowing simple and uniform Web user interfaces (e.g. Internet Explorer 7.0 and Firefox 1.1) to subscribe and access frequently changing business services. This undoubtedly lowers the entry barrier for end users to play the role of service providers or consumers in a sheer service-oriented environment across the Internet
Warming kettle for storing mannitol injection (1980)

Journal Article Warming kettle for storing mannitol injection Get access Kenneth R. Scott, Ph.D, Kenneth R. Scott, Ph.D Professor Department of Biomedicinal Chemistry College of Pharmacy and Pharnjacal Sciences Hoieard University Washinftton, DC 20059 Search for other works by this author on: Oxford Academic Google Scholar Alexander F. Bell, Ph.C, Alexander F. Bell, Ph.C Research Associate Department of Biomedicinal Chemistry College of Pharmacy and Pharnjacal Sciences Hoieard University Washinftton, DC 20059 Search for other works by this author on: Oxford Academic Google Scholar Arend J. Thomas Arend J. Thomas Assistant Director Pharmacy Services 'Howard University Hospital Washington, DC 20060 Search for other works by this author on: Oxford Academic Google Scholar American Journal of Hospital Pharmacy, Volume 37, Issue 1, 1 January 1980, Page 16, https://doi.org/10.1093/ajhp/37.1.16a Published: 01 January 1980
The Injectable Cyclooxygenase-2-Specific Inhibitor Parecoxib Sodium Has Analgesic Efficacy When Administered Preoperatively (2001)

Preoperative administration of analgesics may prevent or reduce hyperalgesia and inhibit inflammation and pain by reducing the synthesis of prostaglandins in response to surgical injury. We evaluated in this placebo-controlled study the analgesic efficacy and safety of single doses of parecoxib sodium (20, 40, and 80 mg IV) when administered before oral surgery. Efficacy assessments were recorded during the 24-h period after completion of surgery. All doses of parecoxib sodium were consistently and significantly superior to placebo as measured by time to rescue medication, proportion of patients requiring rescue medication, patient's global assessment, and pain intensity. There were no significant differences between the Parecoxib Sodium 40- and 80-mg groups, suggesting that the analgesic effect of preoperatively administered parecoxib sodium reaches a plateau at 40 mg in this model. Forty-eight percent of the Parecoxib Sodium 40-mg group required rescue medication in the 24-h study period, compared with 93% of patients in the Placebo group. Overall, there were fewer adverse events in parecoxib sodium-treated patients compared with placebo. These findings suggest that preoperative administration of parecoxib sodium, the injectable prodrug of the cyclooxygenase-2 specific inhibitor valdecoxib, is effective, safe, and well tolerated for treating postoperative pain.
Architecture and function of metallopeptidase catalytic domains (2013)

The cleavage of peptide bonds by metallopeptidases (MPs) is essential for life. These ubiquitous enzymes participate in all major physiological processes, and so their deregulation leads to diseases ranging from cancer and metastasis, inflammation, and microbial infection to neurological insults and cardiovascular disorders. MPs cleave their substrates without a covalent intermediate in a single-step reaction involving a solvent molecule, a general base/acid, and a mono- or dinuclear catalytic metal site. Most monometallic MPs comprise a short metal-binding motif (HEXXH), which includes two metal-binding histidines and a general base/acid glutamate, and they are grouped into the zincin tribe of MPs. The latter divides mainly into the gluzincin and metzincin clans. Metzincins consist of globular ∼ 130-270-residue catalytic domains, which are usually preceded by N-terminal pro-segments, typically required for folding and latency maintenance. The catalytic domains are often followed by C-terminal domains for substrate recognition and other protein-protein interactions, anchoring to membranes, oligomerization, and compartmentalization. Metzincin catalytic domains consist of a structurally conserved N-terminal subdomain spanning a five-stranded β-sheet, a backing helix, and an active-site helix. The latter contains most of the metal-binding motif, which is here characteristically extended to HEXXHXXGXX(H,D). Downstream C-terminal subdomains are generally shorter, differ more among metzincins, and mainly share a conserved loop--the Met-turn--and a C-terminal helix. The accumulated structural data from more than 300 deposited structures of the 12 currently characterized metzincin families reviewed here provide detailed knowledge of the molecular features of their catalytic domains, help in our understanding of their working mechanisms, and form the basis for the design of novel drugs.