gebhart/patrepeval huggingface dataset:
Oral testosterone undecanoate reverses erectile dysfunction associated with diabetes mellitus in patients failing on sildenafil citrate therapy alone (2003)

Decreased testosterone levels in patients with ED and type II DM receiving oral antidiabetic against may be responsible for failure to respond to sildenafil citrate therapy. Combination with oral testosterone undecanoate restores sexual function in these patients.
Colchicine for Recurrent Pericarditis (CORP) (2011)

Colchicine is safe and effective for secondary prevention of recurrent pericarditis.
New cysE-pyrE-linked rfa mutation in Escherichia coli K-12 that results in a heptoseless lipopolysaccharide (1985)

A new novobiocin-supersensitive mutant of Escherichia coli K-12 has been characterized biochemically and genetically. Lipopolysaccharide prepared from this mutant strain is truncated and contains 2-keto-3-deoxyoctulosonic acid as its only core sugar. This new core-defective mutation, designated rfa-2, results in increased sensitivity to several hydrophobic and some hydrophilic agents. Genetic analysis of the rfa mutant indicated that the rfa-2 locus is located at 81 min on the chromosome. The order of the genes in this region based on transduction analysis is xyl cysE rfa-2 rfaD70 pyrE. P1 transduction analyses indicate that the rfa-2 marker is nonallelic with the recently described cysE-pyrE-linked rfaD70 locus. Plasmids carrying the wild-type rfaD70+ allele failed to abolish the rfa-2 phenotypes. Further, the rfaD gene product, ADP-L-glycero-D-mannoheptose-6-epimerase, was detected in crude extracts of a rfa-2 mutant strain, CL609, and was absent in the rfaD70 mutant. The wild-type rfa-2 allele codes either for a specific heptose biosynthetic enzyme (different from the rfaD gene product) or an enzymatic activity required for the addition of heptose to the lipid A-2-keto-3-deoxyoctulosonic acid acceptor.
Ultrafast Manipulation of Strong Coupling in Metal−Molecular Aggregate Hybrid Nanostructures (2010)

We demonstrate an ultrafast manipulation of the Rabi splitting energy Ω(R) in a metal-molecular aggregate hybrid nanostructure. Femtosecond excitation drastically alters the optical properties of a model system formed by coating a gold nanoslit array with a thin J-aggregated dye layer. Controlled and reversible transient switching from strong (Ω(R) ≃ 55 meV) to weak (Ω(R) ≈ 0) coupling on a sub-ps time scale is directly evidenced by mapping the nonequilibrium dispersion relations of the coupled excitations. Such a strong, externally controllable coupling of excitons and surface plasmon polaritons is of considerable interest for ultrafast all-optical switching applications in nanoscale plasmonic circuits.
Characterization of antigenic peptides presented by HLA-B44 molecules on tumor cells expressing the geneMAGE-3 (1996)

The amino acid sequence of the protein encoded by the gene MAGE-3 was screened for peptides containing the binding motif for HLA-B44. Nine peptides were synthesized, and their binding affinity for HLA-B*4402 and -B*4403 was analyzed in an HLA class I alpha-chain refolding assay. Four peptides with binding affinity for HLA-B*4403 were chosen for in vitro cytotoxic T-lymphocyte induction assays using as antigen-presenting cells peptide-pulsed, autologous activated B lymphoblasts from a healthy, B*4403+ donor. Peptide-specific effectors could be raised only against one peptide, M3-167. Cytotoxic T lymphocytes specific for this peptide were also able to recognize melanoma cell lines expressing HLA-B44 and the gene MAGE-3, strongly suggesting that M3-167 is a naturally processed MAGE-3-encoded epitope presented by HLA-B44. M3-167 is a I amino acid N-terminal extension of M3-168, a naturally processed epitope MAGE-3-encoded epitope presented by HLA-A1 that has been previously described. TAP binding studies of these 2 peptides revealed that the TAP affinity of M3-167 is about 9-fold higher than that of M3-168. M3-167 or a longer precursor could be transported into the endoplasmatic reticulum, where it could be trimmed for presentation by HLA-A1 or -B44 molecules. Taken together, our data suggest that M3-167 could be an immunodominant peptide encoded by the gene MAGE-3.
Biomedical applications of THz imaging (2004)

The technology behind optically-driven terahertz (THz) system is now well developed and commercial applications of this new technology are now beginning to emerge. The terahertz frequency range (0.1 to 10 THz) covers far infrared wavelengths. Terahertz light has the advantages that it is non-ionizing and is not highly scattered like visible and near-infrared light. Terahertz pulsed imaging (TPI) is a reflection imaging method that has been used successfully in the past for non-medical applications. More recently, a portable TPI has been used to image a variety of human tissues, like teeth, skin and breast.
High-rate tunable ultrasonic force regulated nanomachining lithography with an atomic force microscope (2012)

This paper describes a high-rate tunable nanomachining-based nanolithography technique using an atomic force microscope (AFM). Controlled vibration between the cantilever tip and the sample is introduced to increase the lithographical speed and controllability of the nanomachining process. In this approach, an ultrasonic z vibration of the sample and the resulting ultrasonic force from the nonlinear force-distance interaction between the sample and the cantilever tip are utilized to regulate fabrication depth. A high frequency in-plane circular vibration is introduced between the tip and the sample to control the width of the fabricated features, and to improve the speed of nanolithography. Features (e.g. slots) with dimensions spanning from tens of nanometers to hundreds of nanometers are fabricated in one scan. A lithography speed of tens of microns per second can be achieved, which is significantly higher than other known mechanical-modification-based nanolithography methods. The patterns, that are machined on a thin PMMA film, are transferred to silicon substrate through a reactive ion etching process, which provides a cost-effective tunable approach for the fabrication of nanostructures.
Architecting for DevOps and Continuous Deployment (2015)

Development and Operations (DevOps) in the context of Continuous Deployment (CD) have emerged as an attractive software development movement, which tries to establish a strong connection between development and operations teams. CD is defined as the ability to quickly put new releases into production. We believe that DevOps/CD brings new challenges for architects, which considerably impacts both on their (architectural) design decisions and their organizational responsibilities. We assert that there is an important and urgent need of sufficient research work to gain a deep understanding of how DevOps/CD adoption can influence architecting, architectural decision-making processes and their outcomes in an organization. This PhD research is aimed at understanding and addressing new challenges for designing architectures for supporting DevOps in the context of CD.
Kinetics of M1 muscarinic receptor and G protein signaling to phospholipase C in living cells (2010)

G protein-coupled receptors (GPCRs) mediate responses to external stimuli in various cell types. Early events, such as the binding of ligand and G proteins to the receptor, nucleotide exchange (NX), and GTPase activity at the Galpha subunit, are common for many different GPCRs. For G(q)-coupled M(1) muscarinic (acetylcholine) receptors (M(1)Rs), we recently measured time courses of intermediate steps in the signaling cascade using Förster resonance energy transfer (FRET). The expression of FRET probes changes the density of signaling molecules. To provide a full quantitative description of M(1)R signaling that includes a simulation of kinetics in native (tsA201) cells, we now determine the density of FRET probes and construct a kinetic model of M(1)R signaling through G(q) to activation of phospholipase C (PLC). Downstream effects on the trace membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP(2)) and PIP(2)-dependent KCNQ2/3 current are considered in our companion paper in this issue (Falkenburger et al. 2010. J. Gen. Physiol. doi:10.1085/jgp.200910345). By calibrating their fluorescence intensity, we found that we selected transfected cells for our experiments with approximately 3,000 fluorescently labeled receptors, G proteins, or PLC molecules per microm(2) of plasma membrane. Endogenous levels are much lower, 1-40 per microm(2). Our kinetic model reproduces the time courses and concentration-response relationships measured by FRET and explains observed delays. It predicts affinities and rate constants that align well with literature values. In native tsA201 cells, much of the delay between ligand binding and PLC activation reflects slow binding of G proteins to receptors. With M(1)R and Gbeta FRET probes overexpressed, 10% of receptors have G proteins bound at rest, rising to 73% in the presence of agonist. In agreement with previous work, the model suggests that binding of PLC to Galpha(q) greatly speeds up NX and GTPase activity, and that PLC is maintained in the active state by cycles of rapid GTP hydrolysis and NX on Galpha(q) subunits bound to PLC.
Optimization of beam parameters and iodine quantification in dual-energy contrast enhanced digital breast tomosynthesis (2008)

Dual-Energy Contrast Enhanced Digital Breast Tomosynthesis (DE CEDBT) is a promising technique for breast cancer detection, which combines the strengths of functional and 3D imaging. In the present study, we first focused on the optimization of the acquisition parameters for the low and high-energy projections, which leads to a trade-off between image quality in the recombined slices and the Average Glandular Dose (AGD) delivered to the patient. Optimized parameters were found and experimentally validated on phantom images. Then, we addressed the problem of iodine quantification in the recombined slices. In DE CEDBT, iodine quantification is limited by the z-resolution, due to the restricted angle acquisition inherent to tomosynthesis. We evaluated the lesion thickness above which determination of iodine volumetric concentration is possible. For lesions below this thickness, estimation of iodine concentration is possible if a priori information or a model on the shape of the lesion is available. Iodine quantification for lesions located near the breast boundary is also challenging, due to scatter border effects and variation of the breast thickness in this region. A scatter correction algorithm based on a deconvolution scheme and a thickness compensation algorithm were applied on the low and high-energy projections. Corrected images showed a more accurate quantification of iodine.
Anti-Lipopolysaccharide Immunotherapy im Management of Septic Shock of Obstetric and Gynaecological Origin (1984)

No AccessJournal of Urology1 Oct 1984Anti-Lipopolysaccharide Immunotherapy im Management of Septic Shock of Obstetric and Gynaecological Origin E. Lachman, S.B. Pitsoe, and S.L. Gaffin E. LachmanE. Lachman More articles by this author , S.B. PitsoeS.B. Pitsoe More articles by this author , and S.L. GaffinS.L. Gaffin More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)49924-1AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Anti-Lipopolysaccharide Immunotherapy im Management of Septic Shock of Obstetric and Gynaecological Origin." The Journal of Urology, 132(4), p. 851 © 1984 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 132Issue 4October 1984Page: 851 Advertisement Copyright & Permissions© 1984 by The American Urological Association Education and Research, Inc.MetricsAuthor Information E. Lachman More articles by this author S.B. Pitsoe More articles by this author S.L. Gaffin More articles by this author Expand All Advertisement PDF downloadLoading ...
Cruciate ligament integrity in osteoarthritis of the knee (2005)

ACL rupture is more common among those with symptomatic knee OA compared with those without knee OA. Fewer than half of subjects with ACL rupture recall a knee injury, suggesting that this risk factor for knee OA is underrecognized.
Real-Time Distributed Multi-Object Tracking Using Multiple Interactive Trackers and a Magnetic-Inertia Potential Model (2007)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> This paper presents a method which avoids the common practice of using a complex joint state-space representation and performing tedious joint data association for multiple object tracking applications. Instead, we propose a distributed Bayesian formulation using multiple interactive trackers that requires much lower complexity for real-time tracking applications. When the objects' observations do not interact with each other, our approach performs as multiple independent trackers. However, when the objects' observations exhibit interaction, defined as close proximity or partial and complete occlusion, we extend the conventional Bayesian tracking framework by modeling such interaction in terms of potential functions. The proposed <emphasis emphasistype="italic">“magnetic-inertia”</emphasis> model represents the cumulative effect of virtual physical forces that objects undergo while interacting with each other. It implicitly handles the <emphasis emphasistype="italic">“error merge”</emphasis> and <emphasis emphasistype="italic">“object labeling”</emphasis> problems and thus solves the difficult object occlusion and data association problems in an innovative way. Our preliminary simulations have demonstrated that the proposed approach is far superior to other methods in both robustness and speed. </para>
Dehydration Impairs Cycling Performance, Independently of Thirst: A Blinded Study (2018)

These data indicated that hypohydration decreased cycling performance and impaired thermoregulation independently of thirst, while the subjects were unaware of their hydration status.
Fast Analytical Evaluation of Fiber Nonlinear Noise Variance in Mesh Optical Networks (2017)

We propose a fast analytical model to evaluate fiber nonlinear noise variance for real-time planning of mesh optical networks. This model is based on an incoherent Gaussian noise (IGN) model with related coefficients precalculated and stored for each fiber type. The impact of span length is modeled using a fitting function. For WDM transmissions, channel combination terms are calculated to account for the contributions from various nonlinear interaction sources. The accuracy of the proposed scheme is comprehensively evaluated in extensive simulations. It is shown that, with channels added and dropped at various link locations, the proposed scheme is able to provide sufficiently high accuracy in most of the cases.
The Putative Proteinase Maturation Protein A of <i>Streptococcus pneumoniae</i> Is a Conserved Surface Protein with Potential To Elicit Protective Immune Responses (2000)

Surface-exposed proteins often play an important role in the interaction between pathogenic bacteria and their host. We isolated a pool of hydrophobic, surface-associated proteins of Streptococcus pneumoniae. The opsonophagocytic activity of hyperimmune serum raised against this protein fraction was high and species specific. Moreover, the opsonophagocytic activity was independent of the capsular type and chromosomal genotype of the pneumococcus. Since the opsonophagocytic activity is presumed to correlate with in vivo protection, these data indicate that the protein fraction has the potential to elicit species-specific immune protection with cross-protection against various pneumococcal strains. Individual proteins in the extract were purified by two-dimensional gel electrophoresis. Antibodies raised against three distinct proteins contributed to the opsonophagocytic activity of the serum. The proteins were identified by mass spectrometry and N-terminal amino acid sequencing. Two proteins were the previously characterized pneumococcal surface protein A and oligopeptide-binding lipoprotein AmiA. The third protein was the recently identified putative proteinase maturation protein A (PpmA), which showed homology to members of the family of peptidyl-prolyl cis/trans isomerases. Immunoelectron microscopy demonstrated that PpmA was associated with the pneumococcal surface. In addition, PpmA was shown to elicit species-specific opsonophagocytic antibodies that were cross-reactive with various pneumococcal strains. This antibody cross-reactivity was in line with the limited sequence variation of ppmA. The importance of PpmA in pneumococcal pathogenesis was demonstrated in a mouse pneumonia model. Pneumococcal ppmA-deficient mutants showed reduced virulence. The properties of PpmA reported here indicate its potential for inclusion in multicomponent protein vaccines.
Spatially resolved wettability measurements using nmr wettability index (2019)

Wettability is a crucial petrophysical parameter for determining accurate production rates in oil and gas reservoirs. However, industry standard wettability measurements (Amott Test and USBM) are expensive and time consuming. It is known that NMR response varies as a function of wettability change in rock core plug samples. This information was used to develop an NMR wettability index (NWI) based on T2 distributions. This NWI is capable of measuring changes in wettability as a function of oil/water saturations unlike traditional methods which are based on measurements at Swi and Sor only. In addition, these oil/water saturations are determined without the aid of any special oil or brine, such as D2O. This allows the NMR method to nondestructively monitor changes in wettability in real time (i.e. during a flooding experiment or an aging procedure). In this work, we have coupled this T2-based NWI to spatially resolved T2 NMR measurements to monitor changes in wettability and saturation along rock core plugs. In order to derive an NMR wettability index, NMR T2 spectra of 100% brine saturated, 100% oil saturated, bulk oil and bulk brine are needed. These spectra are then mixed to give a predicted T2 spectrum which is compared (via a least squares fit) to a T2 spectrum recorded from a sample partially saturated with both water and oil and whose wettability is to be determined. For initial testing, three sandstone samples were employed along with 2% KCl brine and dodecane. To achieve sample states of mixed wettability, 100% brine saturated samples had dodecane pushed into them via centrifugation. Centrifugation at different speeds resulted in samples of varying bulk and spatial wettabilities from which NWI parameters and oil/water saturations were determined. The bulk wettabilities were compared to measurements done using the standard Amott test and oil/water saturations were confirmed by repeating experiments using NMR invisible D2O.
Trace-based mobile network emulation (1997)

Subjecting a mobile computing system to wireless network conditions that are realistic yet reproducible is a challenging problem. In this paper, we describe a technique called trace modulation that re-creates the observed end-to-end characteristics of a real wireless network in a controlled and repeatable manner. Trace modulation is transparent to applications and accounts for all network traffic sent or received by the system under test. We present results that show that it is indeed capable of reproducing wireless network performance faithfully.
Expression of epithelial cell adhesion molecule in carcinoma cells present in blood and primary and metastatic tumors (2005)

The epithelial cell adhesion molecule (EpCAM) is involved in homophilic cell-cell adhesion in normal epithelia and is frequently overexpressed in primary and metastatic adenocarcinomas. It has been postulated that during detachment and dissemination of tumor cells, EpCAM may be down-regulated. Circulating tumor cells (CTC) may demonstrate this phenomenon as they have successfully escaped their local microenvironment and entered the circulation. EpCAM expression of CTC was compared to tumor cells in paraffin-embedded tissue arrays containing various benign diseases and carcinomas. EpCAM expression on CTC was determined by flow cytometry (FCM) and by immunohistochemistry (IHC) in paraffin-embedded tissue. To permit comparison of FCM results to those derived by IHC, EpCAM was quantified on cancer cell lines by FCM and then paraffin-embedded cell-blocks of these lines were used as staining guides for IHC analysis of tissue arrays. By IHC, 97% (384/397) of solid tissues analyzed had detectable EpCAM, with 72% of tissues showing antigen expression levels of > or =400,000 EpCAM molecules per cell. FCM analysis of CTC from 100 metastatic carcinoma patients with > or =2 CTC/90 microl blood showed EpCAM expression ranging from 9,900 to 246,000 (mean 49,700) antigens per cell. EpCAM expression was approximately 10-fold lower on CTC as compared to primary and metastatic tissues, suggesting that EpCAM expression is transient and dependent upon the local micro-environment. This supports the hypothesis that this adhesion molecule is down-regulated on carcinoma cells in the circulation.
<i>In situ</i> verification of single-domain III-V on Si(100) growth via metal-organic vapor phase epitaxy (2008)

Reflectance anisotropy spectroscopy (RAS) was used in situ for the quantification of antiphase domains on surfaces of thin GaP films deposited onto Si(100) by metal-organic vapor phase epitaxy (MOVPE). The preparation of a single-domain GaP∕Si(100) surface was determined via the analysis of RAS peak intensities in reference to the well-known P-rich surface reconstruction of homoepitaxially grown GaP(100). Both preprocessed Si(100) substrates and MOVPE as-grown GaP∕Si(100) films were also characterized ex situ by atomic force microscopy to identify the formation of mono- and diatomic surface steps and to analyze of the domain distribution, respectively.
Analysis of clinical risk factors associated with mortality of severe trauma patients with acute lung injury (2009)

Objective To identify the potential risk factors affecting mortality rate of ALl in severe trauma population. Method It was a retrospective cohort study treating trauma as a single cause for emergency depart-ment (ED)) and emergency intensive care unit (EICU) admissions. Eighteen potential risk factors affecting the mortality of ALI were examined by univariate and multivariate logistic analyses in these severe trauma patients. Re-sults There were 343 severe trauma patients with post-traumatic ALI admitted to ED and EICU the Second Affili-ated Hospital Medical College,Zhejiang University,during the study period. The five risk factors that affected the mortality with unadjusted odd ratios (ORs) and 95% confidence intervals (CIs) were (1) APACHE Ⅱ score, (2)duration of trauma, (3) age, (4) aspiration of gastric contents, and (5) DIC. Specific risk factors also affected different patients subpepulations at different degrees. Conclusions Factors of APACHE Ⅱ score and aspiration of gastric contents that can predict the mortality of ALl may exist in the early stage of trauma. Duration of trauma and DIC that greatly affect the short- and long-term development of ALI deserve special attention. Elderly patients (aged beyond 65 years) are the independent risk factor for the secondary sepsis and deterioration of pulmonary function. Patients with these risk factors need aggressive supportive care as early as possible in order to prevent fur-ther aggravation. 

Key words: 
Trauma;  Acute lung injury;  Mortality;  Risk factors;  APACHE Ⅱ score