gebhart/patrepeval huggingface dataset:
Programmable Clock Generation and Synchronization for USB Audio Systems (2011)

Following an overview of the various schemes used to move audio across a USB link, the paper describes an architecture for both the synchronization and the synthesis of high frequency clocks from information in a hidden-clock data transfer scheme, suitable for implementation on a modern Programmable System on Chip. The work was originally carried out to support the generation of multiple standard audio master clock frequencies from a local crystal clock, and to facilitate their exact synchronization to the 1ms USB packet interval coming from a mobile audio host. It has since found application in a wider range of communications systems. The use of the techniques described in this paper to create a high frequency master clock synchronized to repetitive low frequency signal is the subject of a Cypress patent application.
Inhibitor of interleukin‐2 in rheumatoid synovial fluid (1987)

Although large numbers of T cells infiltrate the synovium of patients with rheumatoid arthritis (RA), the responses of these cells, as present in the blood and synovial fluid (SF), to exogenous interleukin-2 (IL-2) and their production of IL-2 are diminished. To investigate this functional defect, RA SF were examined for the presence of inhibitors of IL-1 and IL-2. A factor was found which inhibited the IL-2-induced proliferation of mitogen-stimulated human T cells and the IL-1-induced proliferation of C3H/Hej mouse thymocytes, but not IL-1-induced fibroblast proliferation. On AcA 54 Ultrogel filtration, the inhibitory activity resided in a fraction with an apparent molecular weight of greater than 70 kd and a major pI of 6.8. The inhibitory effect of RA SF on lymphocyte proliferation was partially corrected with IL-2, but not with IL-1. In the presence of RA SF, normal lymphocytes showed not only a decreased response to exogenous IL-2, but also a decreased production of IL-2. The presence of an inhibitor of IL-2 in RA SF could contribute to the IL-2-related T cell defects observed in RA.
Signals and Systems at Montana Tech (2013)

For over 100 years, there has been an incredible amount of knowledge amassed concerning hormones in the endocrine system and their central role in human health. Hormones represent a diverse group of biomolecules that are released by glands, communicate signals to their target tissue, and are regulated by feedback loops to maintain organism health. Many disease states, such as diabetes and reproductive disorders, stem from misregulation or dysfunction of hormones. Increasing research is illuminating the intricate roles of metal ions in the endocrine system where they may act advantageously in concert with hormones or deleteriously catalyze hormone-associated disease states. As the critical role of metal ions in the endocrine system becomes more apparent, it is increasingly important to untangle the complex mechanisms underlying the connections between inorganic biochemistry and hormone function to understand and control endocrinological phenomena. This tutorial review harmonizes the interdisciplinary fields of endocrinology and inorganic chemistry in the newly-termed field of "metalloendocrinology". We describe examples linking metals to both normal and aberrant hormone function with a focus on highlighting insight to molecular mechanisms. Hormone activities related to both essential metal micronutrients, such as copper, iron, zinc, and calcium, and disruptive nonessential metals, such as lead and cadmium are discussed.
Study on stereometric parameters of optic nerve head of normal, big-cupped disk and glaucomatous eyes using Heidelberg retina tomograph. (2000)

There is certain difference of optic nerve head between the normal subjects and big-cupped disk and patients with POAG.
Microwave Assisted Synthesis of ZnO Nanoparticles: Effect of Precursor Reagents, Temperature, Irradiation Time, and Additives on Nano-ZnO Morphology Development (2013)

The effect of different variables (precursor reagents, temperature, irradiation time, microwave radiation power, and additives addition) on the final morphology of nano-ZnO obtained through the microwave assisted technique has been investigated. The characterization of the samples has been carried out by field emission scanning electron microscopy (FE-SEM) in transmission mode, infrared (FTIR), UV-Vis spectroscopy, and powder X-ray diffraction (XRD). The results showed that all the above-mentioned variables influenced to some extent the shape and/or size of the synthetized nanoparticles. In particular, the addition of an anionic surfactant (sodium di-2-ethylhexyl-sulfosuccinate (AOT)) to the reaction mixture allowed the synthesis of smaller hexagonal prismatic particles (100 nm), which show a significant increase in UV absorption.
Toll-like Receptor 2 Ligands Regulate Monocyte Fcγ Receptor Expression and Function (2013)

Fcγ receptor (FcγR) clustering on monocytes/macrophages results in phagocytosis and inflammatory cytokine production, which serve to eliminate antibody-opsonized targets and activate neighboring immune cells. Toll-like receptor 2 (TLR2), which recognizes a range of both bacterial and fungal components, elicits strong proinflammatory responses in these cells when stimulated by ligands, either natural or synthetic. Thus, we explored the possibility that TLR2 agonists could strengthen FcγR activity within the context of antibody therapy. Human peripheral blood monocytes treated with the TLR2 agonist Pam2CSK4 showed significantly enhanced FcγR-mediated cytokine production as well as phagocytic ability. An examination of the molecular mechanism behind this enhancement revealed increased expression of both FcγRIIa and the common γ subunit following Pam2CSK4 treatment. Interestingly however, expression of the inhibitory receptor FcγRIIb was also modestly increased. Further investigation revealed that Pam2CSK4 also dramatically decreased the expression of SHIP, the major mediator of FcγRIIb inhibitory activity. Using a murine Her2/neu solid tumor model of antibody therapy, we found that Pam2CSK4 significantly enhanced the ability of anti-Her2 antibody to reduce the rate of tumor growth. To verify that the FcγR enhancement was not unique to the diacylated Pam2CSK4, we also tested Pam3CSK4, a related triacylated TLR2 agonist. Results showed significant enhancement in FcγR function and expression. Taken together, these findings indicate that TLR2 activation can positively modulate FcγR and suggest that TLR2 agonists should be considered for testing as adjuvants for antitumor antibody therapy.
3-Nitropropionic Acid - Exogenous Animal Neurotoxin and Possible Human Striatal Toxin (1991)

3-Nitropropionic acid (3-NPA)--a suicide inhibitor of succinate dehydrogenase--is a widely distributed plant and fungal neurotoxin known to induce a damage to basal ganglia, hippocampus, spinal tracts and peripheral nerves in animals. Recent reports from Northern China indicate that 3-NPA is also likely to be responsible for the development of putaminal necrosis with delayed dystonia in children after ingestion of mildewed sugar cane. This article discusses the role of 3-NPA in the causation of the disease in China, its neurotoxic effects in animals and the potential role for this compound as a probe of selective neuronal vulnerability.
A Highly Stable Quadruply Hydrogen-Bonded Heterocomplex Useful for Supramolecular Polymer Blends (2005)

The butyl urea of guanosine (UG) presents an ADDA hydrogen-bonding array that is complementary to the DAAD array of 2,7-diamido-1,8-naphthyridine (DAN). The stability of the DAN.UG complex was measured by fluorimetry using the fluorescence resonance energy transfer (FRET) from the naphthyridine ring to a coumarin 343 moiety linked covalently to the UG unit. The quadruply hydrogen-bonded complex is extremely stable with a measured association constant, Kassoc, of 3 x 108 M-1. Unlike related hydrogen-bonding modules, the guanosine urea, UG, contains a relatively fixed tautomeric form and only weakly self-associates (Kdimer = ca. 200 M-1). The DAN unit was linked to a styrene-based monomer and copolymerized with styrene to form a polymer (PS-DAN) containing a controlled number of the DAAD recognition units. Likewise, a methacrylate monomer containing the UG unit was copolymerized with butyl methacrylate to form a polymer (PBMA-UG). Blends formed from PS-DAN and PBMA-UG were characterized by DSC, SEC, and viscometry. The importance of selective heterocomplexation and weak self-association in forming the blended networks was demonstrated by using a ureidopyrimidinone (UPy) unit, which also forms strong heterocomplexes with DAN but is able to strongly self-associate.
Activation/modulation of adaptive immunity emerges simultaneously after 17DD yellow fever first-time vaccination: is this the key to prevent severe adverse reactions following immunization? (2007)

Over past decades the 17DD yellow fever vaccine has proved to be effective in controlling yellow fever and promises to be a vaccine vector for other diseases, but the cellular and molecular mechanisms by which it elicits such broad-based immunity are still unclear. In this study we describe a detailed phenotypic investigation of major and minor peripheral blood lymphocyte subpopulations aimed at characterizing the kinetics of the adaptive immune response following primary 17DD vaccination. Our major finding is a decreased frequency of circulating CD19+ cells at day 7 followed by emerging activation/modulation phenotypic features (CD19+interleukin(IL)10R+/CD19+CD32+) at day 15. Increased frequency of CD4+human leucocyte antigen D-related(HLA-DR+) at day 7 and CD8+HLA-DR+ at day 30 suggest distinct kinetics of T cell activation, with CD4+ T cells being activated early and CD8+ T cells representing a later event following 17DD vaccination. Up-regulation of modulatory features on CD4+ and CD8+ cells at day 15 seems to be the key event leading to lower frequency of CD38+ T cells at day 30. Taken together, our findings demonstrate the co-existence of phenotypic features associated with activation events and modulatory pathways. Positive correlations between CD4+HLA-DR+ cells and CD4+CD25high regulatory T cells and the association between the type 0 chemokine receptor CCR2 and the activation status of CD4+ and CD8+ cells further support this hypothesis. We hypothesize that this controlled microenviroment seems to be the key to prevent the development of serious adverse events, and even deaths, associated with the 17DD vaccine reported in the literature.
Statistical information and properties of sufficiency (1936)

Abstract In the theory of statistical estimation put forward by Fisher, an essential feature is the concept of statistical information, defined for estimates normally distributed as the reciprocal of their sampling variance, and more generally by the variance of ∂L/∂θ, where L is the logarithm of the likelihood function corresponding to our estimate of a parameterθ. The expected value (∂L/∂θ) is zero, so that we may write I = E(∂L/∂θ)2. (1) If ∂L/∂θ corresponds instead to the original sample of n independent observations from which our estimate was derived, its variance will be n times the information per observation, since ∂L/∂θ is then the sum of n similar components, and (1) will give the information in our sample.
Modulation of the Bovine Trophoblastic Innate Immune Response by<i>Brucella abortus</i> (2008)

Brucellosis is still a widespread zoonotic disease. Very little is known about the interaction between Brucella abortus and trophoblastic cells, which is essential for better understanding the pathogenesis of the Brucella-induced placentitis and abortion, a key event for transmission of the disease. The goal of this study was to evaluate the profile of gene expression by bovine trophoblastic cells during infection with B. abortus. Explants of chorioallantoic membranes were inoculated with B. abortus strain 2308. Microarray analysis was performed at 4 h after infection, and expression of cytokines and chemokines by trophoblastic cells was assessed by real-time reverse transcription-PCR at 6 and 12 h after inoculation. In addition, cytokine and chemokine expression in placentomes from experimentally infected cows was evaluated. Expression of proinflammatory genes by trophoblastic cells was suppressed at 4 h after inoculation, whereas a significant upregulation of CXC chemokines, namely, CXCL6 (GCP-2) and CXCL8 (interleukin 8), was observed at 12 but not at 6 h after inoculation. Placentomes of experimentally infected cows had a similar profile of chemokine expression, with upregulation of CXCL6 and CXCL8. Our data indicate that B. abortus modulates the innate immune response by trophoblastic cells, suppressing the expression of proinflammatory mediators during the early stages of infection that is followed by a delayed and mild expression of proinflammatory chemokines, which is similar to the profile of chemokine expression in the placentomes of experimentally infected cows. This trophoblastic response is likely to contribute to the pathogenesis of B. abortus-induced placentitis.
Novel dry electrodes for ECG monitoring (2007)

The development, fabrication and characterization of two novel dry bioelectrodes--conductive and capacitive ones--for biopotential monitoring are presented. The new electrodes have the potential to improve the applicability of dry electrodes in ambulant recording of ECG by reducing motion artifacts as well as the contact impedance to the skin. Furthermore, a passive filter network is integrated into the new electrodes to suppress slow offset fluctuation of the ECG signal caused e.g. by motions like breathing or changes in the electrode-skin interface properties. Compared to standard gel electrodes these new electrodes exhibit equivalent and superior contact impedances and biosignals. The integrated filter network effectively suppresses fluctuating offset potentials.
Compact Wideband Dual Circularly Polarized Substrate Integrated Waveguide Horn Antenna (2016)

In this communication, a compact circularly polarized (CP) substrate integrated waveguide (SIW) horn antenna is proposed and investigated. Through etching a sloping slot on the common broad wall of two SIWs, mode coupling is generated between the top and down SIWs, and thus, a new field component as TE01 mode is produced. During the coupling process along the sloping slot, the difference in guide wavelengths of the two orthogonal modes also brings a phase shift between the two modes, which provides a possibility for radiating the CP wave. Moreover, the two different ports will generate the electric field components of TE01 mode with the opposite direction, which indicates the compact SIW horn antenna with a dual CP property can be realized as well. Measured results indicate that the proposed antenna operates with a wide 3-dB axial ratio bandwidth of 11.8% ranging from 17.6 to 19.8 GHz. The measured results are in good accordance with the simulated ones.
Compact Watershed and Preemptive SLIC: On Improving Trade-offs of Superpixel Segmentation Algorithms (2014)

A major insight from our previous work on extensive comparison of super pixel segmentation algorithms is the existence of several trade-offs for such algorithms. The most intuitive is the trade-off between segmentation quality and runtime. However, there exist many more between these two and a multitude of other performance measures. In this work, we present two new super pixel segmentation algorithms, based on existing algorithms, that provide better balanced trade-offs. Better balanced means, that we increase one performance measure by a large amount at the cost of slightly decreasing another. The proposed new algorithms are expected to be more appropriate for many real time computer vision tasks. The first proposed algorithm, Preemptive SLIC, is a faster version of SLIC, running at frame-rate (30 Hz for image size 481x321) on a standard desktop CPU. The speed-up comes at the cost of slightly worse segmentation quality. The second proposed algorithm is Compact Watershed. It is based on Seeded Watershed segmentation, but creates uniformly shaped super pixels similar to SLIC in about 10 ms per image. We extensively evaluate the influence of the proposed algorithmic changes on the trade-offs between various performance measures.
Globally Optimal Distributed Power Control for Nonconcave Utility Maximization (2010)

We consider a distributed power control algorithm for infrastructureless ad hoc wireless networks, where each link distributively and asynchronously updates its transmission power with limited message passing among links. This algorithm provably converges to the set of global optimal solutions despite the non-convexity of the power control problem. In contrast with existing distributed power control algorithms, our algorithm makes no stringent assumptions on the system utility functions. In particular, the utility function is allowed to be concave or non-concave, differentiable or non-differentiable, continuous or discontinuous, and monotonic or non-monotonic.
Pattern extraction and recognition for noisy images using the three-layered BP model (1991)

The authors present a novel pattern recognition architecture using three-layered backpropagation (BP) models. The proposed architecture consists mainly of the following two completely separate functions: extraction of a target pattern and recognition of the extracted pattern. It is possible that the proposed architecture detects where and what the target pattern is. In order to realize these functions, the following networks are introduced: filtering network, position network, size network, frame-working network, and categorizing networks. Results of handwritten-letter recognition experiments show that the proposed architecture has the ability to recognize a deformed target pattern in an original image with much noise, especially lumped noises.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A 2-GHz low-phase-noise integrated LC-VCO set with flicker-noise upconversion minimization (2000)

A fully integrated 2-GHz very low-phase-noise LC-tank voltage-controlled oscillator (VCO) set with flicker noise upconversion minimization is presented. Using only integrated planar inductors, the measured phase noise is as low as -125.1 dBc/Hz at 600-kHz offset and -138 dBc/Hz at 3 MHz. The excellent phase-noise performance is achieved by means of an in-house-developed integrated inductor simulator optimizer. To minimize the upconversion of flicker noise to 1/f/sup 3/ phase noise, a flicker-noise upconversion factor is defined, which can easily be extracted from circuit simulation. The technique is applied to demonstrate the relationship between the flicker-noise upconversion and the overdrive level of the oscillators' MOS cross-coupled pair and to develop circuit balancing techniques to even further reduce the flicker-noise upconversion. The 1/f/sup 3/ phase-noise corner is minimized to be less than 15 kHz. The VCO's are implemented in a three-metal layer, 0.65-/spl mu/m BiCMOS process, using only MOS active devices.
A low-power microcontroller with on-chip self-tuning digital clock-generator for variable-load applications (2003)

Clock disabling for power management has been implemented in some microcontrollers, but the wake-up time of Xtal/PLL-based systems is incompatible with fast interrupt response. On the other hand, hardwired on-chip clocking has been used for dedicated circuits. We illustrate the design issues of a general-purpose microcontroller core with a programmable on-chip fully-digital clock generator. The CPU is compatible with the PIC16C57 instruction set and supports software-controlled clocking modes-ranging from 44 MHz up to 124 MHz; on-line self-tuning of the maximum full-speed frequency in case of peak-performance requirements; ultra-fast wake-up even with totally disabled clock generator-namely 8.6 ns.
The impact of embedded wafer level BGA package on the antenna performance (2013)

In this article, we present a study about the impact of embedded wafer level ball grid array (eWLB) on characteristics of antenna. The antenna in package is a promising solution for integration of antennas and eWLB technology enables integration of passive components and antennas into the redistribution layer (RDL). The antenna radiates perpendicular to the package in broadside into the package. There are different parameters such as size, shape, and thickness of the eWLB package which affect the radiation pattern significantly. Moreover, the materials properties of package like relative permittivity (ε <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">r</sub> ) and loss tangent (tanδ) impact the impedance bandwidth, gain and efficiency of antenna and have to be taken into account. The other important parameter to design the antenna in package is the distance of antenna to the reflector. We present the feasibility of an antenna with backside metallization as an integrated reflector in an 8 mm × 8 mm eWLB package. The measurement and simulation results show that eWLB is an attractive candidate for mm-wave applications.
Nucleotide Sequence of the Hind-C Fragment of Simian Virus 40 DNA. Comparison of the 5'-Untranslated Region of Wild-Type Virus and of Some Deletion Mutants (1979)

We report here the nucleotide sequence of the wild-type simian virus 40 (strain 776) restriction fragment Hind-C-P1 DNA and of the homologous region of various mutant DNAs which lack part of this fragment. During this work, we detected between EcoRII fragments N and G an additional, 17-base-pair EcoRII fragment, fragment P, which had previously been overlooked. Also, an additional dTpdG dinucleotide at residues L 339--340 was observed by sequence analysis of the DNA minus (E) strand; the presence of this dinucleotide was masked on sequencing patterns of the plus strand due to the persistence (during gel electrophoresis) of some secondary structures in the strand's 5'-terminal region. These nucleotide additions raise the total length of SV40 DNA to 5243 base pairs. The longest tandemly repeated segment in SV40 DNA now extends over 72 base pairs. SV40 deletion mutants dl 893 and dl 894 and SV40 strains Rh 911 and 1801 all lack an identical 72-base-pair-long DNA segment in the Hind-C region. This deletion corresponds precisely to one of the two aforementioned large tandemly repeated sequences. Mutant dl 895 lacks 66 base pairs, 63 of which are part of the former repetition. All these mutants, except dl 895, very probably were generated by an intramolecular, homologous recombination event. The 40-base-pair deletion in mutant dl 1811 includes the major capping site of SV40 late RNA. dl 1812 lacks only three base pairs, which are part of the overlapping HhaI and HpaII restriction sites at position 0.725--0.726.