gebhart/patrepeval huggingface dataset:
A Combined Coding and Modulation Approach for Communication over Dispersive Channels (1973)

The concept of combining the design of the error-correcting-coding approach and the modulation format is treated in general terms and its effectiveness is demonstrated by a specific implementation referred to as Codem I. A new decoding algorithm is presented, which has the interesting property that the only channel measurement information utilized is the relative reliability of each received digit. The effectiveness of this decoding technique is demonstrated by computer simulation over three different channel models for dispersive channels. Comparisons of the performance of Codem I with the more conventional 16-tone (four-phase DPSK) HF modem are obtained by actual field results as well as by computer simulations. Improvement in error probability in the region of two orders of magnitude is demonstrated when both systems are operating under similar channel conditions and at equal data rates. A further improvement is demonstrated when channel measurement information is used to reject a small percentage (typically less than 3 percent) of codewords that are considered unreliable.
ORION: Online Regularized Multi-task Regression and Its Application to Ensemble Forecasting (2014)

Ensemble forecasting is a well-known numerical prediction technique for modeling the evolution of nonlinear dynamic systems. The ensemble member forecasts are generated from multiple runs of a computer model, where each run is obtained by perturbing the starting condition or using a different model representation of the dynamic system. The ensemble mean or median is typically chosen as the consensus point estimate of the aggregated forecasts for decision making purposes. These approaches are limited in that they assume each ensemble member is equally skill ful and do not consider their inherent correlations. In this paper, we cast the ensemble forecasting task as an online, multi-task regression problem and present a framework called ORION to estimate the optimal weights for combining the ensemble members. The weights are updated using a novel online learning with restart strategy as new observation data become available. Experimental results on seasonal soil moisture predictions from 12 major river basins in North America demonstrate the superiority of the proposed approach compared to the ensemble median and other baseline methods.
NOx Reduction Kinetics Mechanisms and Radical-Induced Autoignition Potential of EGR in I.C. Engines Using Methanol and Hydrogen (2001)

<div class="htmlview paragraph">This numerical study examines the chemical-kinetics mechanism responsible for EGR NO<sub>x</sub> reduction in standard engines. Also, it investigates the feasibility of using EGR alone in hydrogen-air and methanol-air combustion to help generate and retain the same radicals previously found to be responsible for the inducement of the autoignition (in such mixtures) in IC engines with the SONEX Combustion System (SCS) piston micro-chamber. The analysis is based on a detailed chemical kinetics mechanism (for each fuel) that includes NO<sub>x</sub> production. The mechanism for H-air-NO<sub>x</sub> combustion makes use of 19 species and 58 reactions while the methanol-air-NO<sub>x</sub> mechanism is based on the use of 49 species and 227 reactions.</div> <div class="htmlview paragraph">It was earlier postulated that the combination of thermal control and charge dilution provided by the EGR produces an alteration in the combustion mechanisms (for both the hydrogen and methanol cases) that lowers peak cycle temperatures-thus greatly reducing the production of NO<sub>x</sub>. Through the present numerical calculations, the actual chemical-kinetics mechanisms responsible for these lower peak temperatures and emissions have been identified. The calculations clearly show the effect of EGR in lowering peak temperatures and pinpoint how this in-turn results in lower NO<sub>x</sub> emissions (for both fuels). Further, for stoichiometric mixtures, the study is able to determine whether (or not) EGR by itself is capable of providing the intermediate species and radicals previously found to induce autoignition (and TO enhance combustion) in hydrogen and methanol IC engines using the SCS technology (H<sub>2</sub>O<sub>2</sub> CH<sub>2</sub>O and HO<sub>2</sub> for the case of methanol). For both fuels the results are negative. The same findings are argued to be true for 2-stroke engines using exhaust gas carryover to provide charge dilution and thermal heating control.</div>
Neuromodulatory Effects of Gonadotropin Releasing Hormone on Olfactory Receptor Neurons (2000)

The terminal nerve is an anterior cranial nerve that innervates the lamina propria of the chemosensory epithelia of the nasal cavity. The function of the terminal nerve is ambiguous, but it has been suggested to serve a neuromodulatory role. We tested this hypothesis by exposing olfactory receptor neurons from mudpuppies (Necturus maculosus) to a peptide, gonadotropin releasing hormone (GnRH), that is found in cells and fibers of the terminal nerve. We used voltage-clamped whole-cell recordings to examine the effects of 0. 5-50 micrometer GnRH on voltage-activated currents in olfactory receptor neurons from epithelial slices. We found that GnRH increases the magnitude, but does not alter the kinetics, of a tetrodotoxin-sensitive inward current. This increase in magnitude generally begins 5-10 min after initial exposure to GnRH, is sustained for at least 60 min during GnRH exposure, and recovers to baseline within 5 min after GnRH is washed off. This effect occurred in almost 60% of the total number of olfactory receptor neurons examined and appeared to be seasonal: approximately 67% of neurons responded to GnRH during the courtship and mating season, compared with approximately 33% during the summer, when the sexes separate. GnRH also appears to alter an outward current in the same cells. Taken together, these data suggest that GnRH increases the excitability of olfactory receptor neurons and that the terminal nerve functions to modulate the odorant sensitivity of olfactory receptor neurons.
Oxidation of dibenzothiophene by hydrogen peroxide or monopersulfate and metal–sulfophthalocyanine catalysts: an easy access to biphenylsultone or 2-(2′-hydroxybiphenyl)sulfonate under mild conditions (2003)

A catalytic system consisting of metal–sulfophthalocyanines (MPcS) and monopersulfate or hydrogen peroxide as oxidants was effective in the dibenzothiophene oxidative desulfurization with various yields and selectivities. Oxidations were conducted at room temperature in acetonitrile–water mixed solvent. The dibenzothiophene oxidation involved the step by step formation of dibenzothiophene dioxide and biphenylsultone (dibenzo-1,2-oxathiine 2,2-dioxide), followed by hydrolysis to 2(2′-hydroxybiphenyl)sulfonate and finally catalytic desulfurization to 2-hydroxybiphenyl (2-phenylphenol) and sulfuric acid; all the intermediate compounds were identified. Moreover, catalytic over-oxidation of 2-hydroxybiphenyl, with ring fission and formation of various oxidation products, among them carbon dioxide, oxalic and benzoic acid, was also observed. Among the various MPcS catalysts examined (M = Fe, Co and Ru), the ruthenium derivative exhibited the best performances with persulfate and iron derivative with hydrogen peroxide; in both cases the slow step of the process consisted in the oxidation of dibenzothiophene dioxide to biphenylsultone.
Software reliability (1977)

The paper discusses the basic concepts underlying the issue of software reliability, and argues that programmed exception handling is inappropriate for dealing with suspected software errors. Instead it is shown, using an example program, how exception handling can be combined with the recovery block structure. The result is to improve the effectiveness with which problems due to anticipated faulty input data, hardware components, etc., are dealt with, while continuing to provide means for recovering from unanticipated faults, including ones due to residual software design errors.
Preparation of precursors for the synthesis of analogues of rhazinilam (2014)

Rhazinilam a structurally relatively simple tetracyclic natural product exerts interesting anticancer activities in vitro, which are difficult to reproduce in vivo. Based on the findings accumulated during the synthetic efforts and on the known metabolic sensitivity towards oxidation and acids a modified structural analogue of rhazinilam is proposed. A novel convergent approach towards the heterocyclic biaryl unit is described. The key sequence for the construction of 7 is the Mukaiyama crossed aldol reaction followed by the Staudinger reaction. Using known N-alkylation procedures the introduction of the side chains onto the 3-pyrrolin-2one intermediate 2 needed for the construction of the tetracycle could not be achieved.
Alterations in Protein Accretion and Histochemical Characteristics of the M. Longissimus Dorsi in Pigs Caused by Salbutamol (a β-Adrenergic Agonist) (1990)

Abstract Dietary inclusion of the β-agonist, Salbutamol (3.3 ppm), to growing pigs (50–90 kg body weight, 44 days of treatment) significantly increased the weight of the longissimus dorsi muscle (17%). Histochemical identification of muscle sections from m. longissimus dorsi into slow-twitch (ST) and fast-twitch (FTa and FTb) fibres showed that Salbutamol significantly reduced the relative distribution of FTa fibres in both area and number, whereas the relative distribution in numbers of FTb fibres increased, indicating a conversion of FTa to FTb fibres. Results from the calculated volume contribution of each fibre type (weight of longissimus muscle x relative area of fibre type) indicate that the increased protein accretion in m. longissimus dorsi caused by Salbutamol was mainly associated with hypertrophy in FTb fibres or in histochemically identified non-oxidative fibres. The combined changes in protein accretion and fibre type distribution caused by Salbutamol may however result in a lower aerobic capacity of skeletal muscles.
Combustion Behavior of Solid Oxidizer/Gaseous Fuel Diffusion Flames (2013)

The diffusion flame combustion behavior of several solid oxidizers (ammonium nitrate, phase-stabilized ammonium nitrate, ammonium perchlorate, and ammonium dinitramide) in combination with a hydrocarbon fuel (ethylene) was examined. The oxidizers were first analyzed by differential scanning calorimetry, thermal gravimetric analysis, and evolved gas analysis to gain an understanding of their basic decomposition characteristics. Next, an opposed flow burner was used to establish a diffusion flame between the decomposition products of the oxidizer(s) and the fuel. Regression rates of the solid oxidizer were measured by a linear variable displacement transducer as a function of fuel flow rate. Ammonium dinitramide demonstrated the highest linear regression rate characteristics by up to two orders of magnitude, followed by ammonium perchlorate, phase-stabilized ammonium nitrate, and finally ammonium nitrate. When comparing mass burning rates, ammonium perchlorate compares favorably to solid fuels such as hydroxyl-terminated polybutadiene. In addition, the flame zone(s) were imaged via high-speed photography to provide detailed information of flame characteristics. Flame imaging revealed large melt layers and boiling type behavior for ammonium nitrate and phase-stabilized ammonium nitrate as well as droplet ejection from the melt layer. The goal of this study was to gain an understanding of the fundamental combustion behavior of a diffusion flame between a solid oxidizer and a hydrocarbon fuel as a stepping-stone to more complex systems such as reverse hybrid rockets.
A New Perspective on Environmental Rights after the Charter (1983)

text accompanying note 114, infra, to the effect that squabbling over the actual jurisdictional forum
ELECTRODYNAMIC BRAKING IN HIGH‐SPEED RAIL TRANSPORT (2007)

The paper considers electrodynamic braking of trains, which is of particular importance for high‐speed railway transport from theoretical and technical perspectives. Braking methods used for high‐speed trains should ensure compatibility and redundancy of braking systems. They include a mechanical method (based on adding frictional disks to wheelsets), as well as magnetic braking, which is being currently implemented and based on eddy currents, etc. High‐speed trains have AC/DC engines, for which the principles of electric braking can be applied. Electrodynamic braking is of particular importance for high‐speed transport using linear motors and developing the speed of 400–500 km/h. These traction rolling stocks will not have commonly used trucks. The tests in this area are being conducted in Japan and Germany now. The paper suggests some theoretical and practical solutions to these problems. Schematic diagrams of the locomotive braking and ways of controlling the braking force by varying electric circuit parameters are presented. The authors suggested contact‐free regulation of braking rheostat resistor for controlling braking force in rheostatic braking. A schematic diagram of harmonizing electrified railways and power system's upgrading aimed at ensuring power regeneration is also presented.
[Effect of the collateral circulation on myocardial salvage in patients with acute myocardial infarction]. (1991)

The effects of the extent of coronary collateral circulations, the duration of myocardial ischemia and recanalization of infarct-related vessels on left ventricular function were evaluated in 43 patients with acute anteroseptal myocardial infarction. All patients had complete occlusions of their proximal left anterior descending coronary arteries and were treated with intra-coronary thrombolytic therapy within 8 hours after the onset of their chest pain. The 43 patients were categorized in 4 groups based on the extent of their coronary collaterals in the early period of myocardial infarction and the results of thrombolysis. Group A consisted of 11 patients with well-developed collaterals who had successful thrombolysis. Group B was comprised of 14 patients with poorly developed or no collaterals, and successful thrombolysis. In group C, there were 9 patients with well-developed collaterals and unsuccessful thrombolysis. In group D, there were 9 patients who had poorly or not developed collaterals, and all had unsuccessful thrombolysis. Four weeks after the intervention, ejection fraction (EF) and regional wall motion (RWM) were calculated from the data of the left ventricular angiograms. There was no significant difference in patients' age, sex, nor in peak serum creatine kinase among the 4 groups or the duration of myocardial ischemia between groups A and B. Patients with successful thrombolysis (groups A and B) had significantly higher EF and preserved RWM of infarct areas compared to patients with unsuccessful thrombolysis (groups C and D, p less than 0.05). Thirteen patients with early reperfusion (within 4 hours after the onset of chest pain) had significantly higher EF and better RWM than did 12 patients with late reperfusion and 18 patients with unsuccessful thrombolysis (p less than 0.01). However, there was no significant correlation between the duration of myocardial ischemia and RWM of the infarct areas among 25 patients who had successful thrombolysis (r = -0.3, NS). Patients in group A had higher EF and better RWM of infarct areas than did patients in groups B, C and D (p less than 0.01). In addition, 3 patients with well-developed collaterals had good RWM despite late reperfusion which occurred more than 4 hours after the onset of symptoms. These results suggest that the extent of coronary collaterals during the early period of myocardial infarction and the time delay from the onset of symptoms to the initiation of thrombolytic therapy are important factors for the salvage of left ventricular function in patients with myocardial infarction.
Role of the Cytoplasmic Domain of the NewcastleDisease Virus Fusion Protein in Association with LipidRafts (2003)

To explore the association of the Newcastle disease virus (NDV) fusion (F) protein with cholesterol-rich membrane domains, its localization in detergent-resistant membranes (DRMs) in transfected cells was characterized. After solubilization of cells expressing the F protein with 1% Triton X-100 at 4 degrees C, ca. 40% of total, cell-associated F protein fractionated with classical DRMs with densities of 1.07 to l.14 as defined by flotation into sucrose density gradients. Association of the F protein with this cell fraction was unaffected by the cleavage of F(0) to F(1) and F(2) or by coexpression of the NDV attachment protein, the hemagglutinin-neuraminidase protein (HN). Furthermore, elimination by mutation, of potential palmitate addition sites in and near the F-protein transmembrane domain had no effect on F-protein association with DRMs. Rather, specific deletions of the cytoplasmic domain of the F protein eliminated association with classical DRMs. Comparisons of deletions that affected fusion activity of the protein and deletions that affected DRM association suggested that there is no direct link between the cell-cell fusion activity of the F protein and DRM association. Furthermore, depletion of cholesterol from cells expressing F and HN protein, while eliminating DRM association, had no effect on the ability of these cells to fuse with avian red blood cells. These results suggest that specific localization of the F protein in cholesterol-rich membrane domains is not required for cell-to-cell fusion. Paramyxovirus F-protein cytoplasmic domains have been implicated in virus assembly. The results presented here raise the possibility that the cytoplasmic domain is important in virus assembly at least in part because it directs the protein to cholesterol-rich membrane domains.
Angiopoietin 2 Induces Glioma Cell Invasion by Stimulating Matrix Metalloprotease 2 Expression through the αvβ1 Integrin and Focal Adhesion Kinase Signaling Pathway (2006)

Accumulating evidence reveals a significant correlation between angiopoietin 2 (Ang2) expression and tumor invasion and metastasis in various human cancers, but the major focus of recent studies has been on the angiogenic effects of Ang2. We recently reported that Ang2-stimulated glioma cell invasion results from the up-regulation and activation of matrix metalloprotease 2 (MMP-2) in tumor cells. In this study, we identify a novel mechanism by which Ang2 stimulates MMP-2 expression leading to glioma cell invasion. We show that Ang2 interacts with alpha(v)beta(1) integrin in Tie2-deficient human glioma cells, activating focal adhesion kinase (FAK), p130(Cas), extracellular signal-regulated protein kinase (ERK) 1/2, and c-jun NH(2)-terminal kinase (JNK) and substantially enhancing MMP-2 expression and secretion. The Ang2/alpha(v)beta(1) integrin signaling pathway was attenuated by functional inhibition of beta(1) and alpha(v) integrins, FAK, p130(Cas), ERK1/2, and JNK. Furthermore, expression of a negative regulator of FAK, FAK-related nonkinase, by U87MG/Ang2-expressing glioma xenografts suppressed Ang2-induced MMP-2 expression and glioma cell infiltration in the murine brain. These data establish a functional link between Ang2 interaction with alpha(v)beta(1) integrin and glioma cell invasion through the FAK/p130(Cas)/ERK1/2 and JNK-mediated signaling pathway.
Ineffectiveness of Histone Deacetylase Inhibitors to Induce Apoptosis Involves the Transcriptional Activation of NF-κB through the Akt Pathway (2003)

Histone deacetylase (HDAC) inhibitors are emerging as a new class of anticancer agents for the treatment of solid and hematological malignancies. Although HDAC inhibitors induce cell death through an apoptotic process, little is known about the molecular events that control their effectiveness. In this study, we demonstrate that HDAC inhibitors are limited in their ability to induce apoptosis in non-small cell lung cancer (NSCLC) cell lines despite their ability to effectively inhibit deacetylase activity. Because the anti-apoptotic transcription factor NF-kappa B has been shown to be under the control of HDAC-mediated repression, we analyzed whether HDAC inhibitors activated NF-kappa B in NSCLC cells. HDAC inhibitors effectively stimulated endogenous NF-kappa B-dependent gene expression by up-regulating IL-8, Bcl-XL, and MMP-9 transcripts. The ability of HDAC inhibitors to increase NF-kappa B transcriptional activity was not associated with signaling events that stimulated nuclear translocation, but rather modulated the transactivation potential of the RelA/p65 subunit of NF-kappa B. The inhibition of HDAC activity was associated with the recruitment of the p300 transcriptional co-activator to chromatin in an Akt-dependent manner. Moreover, Akt directly phosphorylated p300 in vitro and was required for stimulating the transactivation potential of the co-activator following the addition of HDAC inhibitors. Selective inhibition of either the phosphoinositide 3-kinase/Akt pathway, or NF-kappa B itself blocked the ability of HDAC inhibitors to activate NF-kappa B and dramatically sensitized NSCLC cells to apoptosis following of the addition of HDAC inhibitors. Our study indicates that the ineffectiveness of HDAC inhibitors to induce apoptosis in NSCLC cancer cells is associated with the ability of these molecules to stimulate NF-kappa B-dependent transcription and cell survival.
Regulation and Function of <i>Escherichia coli</i> Sugar Efflux Transporter A (SetA) during Glucose-Phosphate Stress (2010)

Accumulation of certain nonmetabolizable sugar-phosphates (including α-methyl glucoside-6-phosphate) in Escherichia coli is growth inhibitory and elicits the glucose-phosphate stress response. The transcription factor SgrR activates transcription of the small RNA SgrS under stress conditions. SgrS represses translation of mRNAs encoding sugar transporters. The sgrR and sgrS genes are located directly upstream of setA, and this gene organization is conserved in numerous enteric species, prompting the hypothesis that SetA contributes to the glucose-phosphate stress response. SetA is a proton motive force-driven efflux pump capable of transporting various sugars and sugar analogs in vitro. This study demonstrates that setA expression is induced in response to glucose-phosphate stress, and this requires SgrR. Under stress conditions, setA is cotranscribed with sgrS from the sgrS promoter. A setA mutant exhibits a growth defect under stress conditions that can be complemented by setA in trans, suggesting that SetA contributes to the optimal cellular recovery from stress. Despite previous in vitro evidence that SetA can promote efflux of the stress-causing glucose analog α-methyl glucoside, in vivo data in this study indicate that SetA is not the major efflux pump responsible for removal of α-methyl glucoside under stress conditions.
Towards text knowledge engineering (1998)

We introduce a methodology for automating the maintenance of domain-specific taxonomies based on natural language text understanding. A given ontology is incrementally updated as new concepts are acquired from real-world texts. The acquisition process is centered around the linguistic and conceptual “quality” of various forms of evidence underlying the generation and refinement of concept hypotheses. On the basis of the quality of evidence, concept hypotheses are ranked according to credibility and the most credible ones are selected for assimilation into the domain knowledge base.
Effect of Impeller Level on Power Consumption of Mixing Impellers (1979)

永田らの動力相関式によると, 乱流域の攪拌所要動力は翼取り付け高さによって影響を受けないとされている.しかし産業界においては種々の翼取り付け高さで攪拌操作がしばしば行われているが, この場合翼取り付け高さが攪拌所要動力に影響を及ぼすことが知られている.本報告では, 邪魔板条件時と無邪魔板条件時の乱流域における翼取り付け高さが攪拌所要動力に与える影響を, パドル翼およびタービン翼を用いて検討し定量化した.