gebhart/patrepeval huggingface dataset:
Augmentative and alternative communication: ethics and authenticity in clinical practice (1989)

This paper delineates certain principles of ethics and relates them specifically to the practice of augmentative and alternative communication (AAC). The authors describe ways to obtain and maintain authenticity in the execution of service delivery through education and resource development. An Authenticity Test for Augmentative and Alternative Communication has been included as a means for clinicians to monitor their commitment to persons with severe communicative impairment, their knowledge of augmentative and alternative communication principles and practices, and their professionalism.
Torsional frequency response of cantilever beams immersed in viscous fluids with applications to the atomic force microscope (2002)

The frequency response of a cantilever beam is strongly dependent on the fluid in which it is immersed. In a companion study, Sader [J. Appl. Phys. 84, 64, (1998)] presented a theoretical model for the flexural vibrational response of a cantilever beam, that is immersed in a viscous fluid, and excited by an arbitrary driving force. Due to its relevance to applications of the atomic force microscope (AFM), we extend the analysis of Sader to the related problem of torsional vibrations, and also consider the special case where the cantilever is excited by a thermal driving force. Since longitudinal deformations of AFM cantilevers are not measured normally, combination of the present theoretical model and that of the companion study enables the complete vibrational response of an AFM cantilever beam, that is immersed in a viscous fluid, to be calculated.
Biotransformation of 6‐thioguanine in inflammatory bowel disease patients: a comparison of oral and intravenous administration of 6‐thioguanine (2011)

The great variability of the AUC per mg for 6-TG observed after p.o. and i.v. administration of 6-TG, was partly explained by variability in activities of metabolizing enzymes. Exposure of 6-TGN was low in all patients.
The fredholm eigenvalues of plane domains (1986)

The problem of how the Fredholm eigenvalue δ(D) of a simply connected domain D varies under “small” perturbations of D has been much studied. The difficulty consists in determining the sense in which such a perturbation is small. Here we consider a metric which arises in the definition of universal Teichmüller space. We show that, with this metric, the Fredholm eigenvalue δ(D) is a locally Lipschitz function of D, if D is a quasiconformal disk.
A single-stage power-factor-corrected AC/DC converter (1999)

This paper presents a single-stage isolated converter topology designed to achieve a regulated DC output voltage having no low-frequency components and a high-input power factor. The topology is derived from the basic two-switch forward converter, but incorporates an additional transformer winding, inductor and a few diodes. The proposed circuit inherently forces the input current to be discontinuous and AC modulated to achieve high-input power factor. The converter output is operated in discontinuous mode to minimize the bulk capacitor voltage variations when the output load is varied. Analysis of the converter is presented, and performance characteristics are given. Design guidelines to select critical components of the circuit are presented. Experimental results on a 150 W 50 kHz universal input (90-265 V) 54.75 V output AC/DC converter are given which confirm the predicted performance of the proposed topology.
Synthesis and application of mesoporous zeolite SBA-15-SO_3H using sodium metasilicate as the silicon source (2007)

Mesoporous zeolite SBA-15-SO_3H containing sulfonic acid groups was prepared under strong acidic and hydrothermal condition.The XRD results showed that the catalyst had well-ordered,regular hexagonal array structure.ETBE was synthesized from tert-butyl alcohol and ethanol over the catalyst.The effects of reaction temperature,ethanol/tert-butylalcohol molar ratio and space velocity on the etherification reaction were investigated.The optimal condition was obtained as follows: reaction temperature 120 ℃,ethanol/tert-butyl-alcohol molar ratio 2∶1,reaction time 5 h.Tert-butyl alcohol conversion of 62.83%.
Optimized Sharable-Slot Allocation Using Multiple Channels to Reduce Data-Gathering Delay in Wireless Sensor Networks (2016)

The demand for event-driven real-time applications for timely and reliable data acquisition is growing in industrial sectors. However, it is challenging to satisfy the requirements since constraints such as limited available energy and bandwidth are inherent in a wireless sensor network. To deal with timely delivery, one desirable approach is to improve network throughput so that more real-time applications with tighter time constraints can be satisfied in any given network. To deal with reliable delivery, the use of a carrier sense multiple access mechanism for data transmission is preferred, along with the use of a sharable slot within which multiple nodes compete to send data. Thus, we present a method of using multiple channels and a way to optimize the size of the sharable slot. The proposed channel-slot-scheduling algorithm tries to optimize the size of a sharable slot when multiple channels are used. The algorithm also deals with situations where nodes generate multiple data packets in each round of a data-gathering period. It is shown through simulation that our approach greatly outperforms others on some selected metrics.
New airborne weather radar systems (1981)

This pajvev reviews the characteristics of airborne weather radars produced since World War II, citing the major technology changes that have been implemented up to the present time. The recent advent of large scale integrated (LSI) circuits has made it possible to design practical color radar displays which are more easily interpreted by the pilot. The paper reviews the weather radar range equation and then justifies the choice of radar parameters to permit the use of current state-of-the-art solid-state potentially reliable low-powered transmitters to provide adequate storm cell detection range. System parameter choices are considered for the use of a solidstate coherent radar system for extracting storm cell turbulence signals which can be of use in displaying their location to the pilot in order to avoid these potentially hazardous areas. It is concluded that this new technology airborne weather radar system will result in a more reliable radar which will also provide the pilot with sufficient navigation information to permit flying closer to large storm cells in areas free from turbulence, thus promoting passenger comfort and safety while conserving fuel.
Minimum register instruction sequencing to reduce register spills in out-of-order issue superscalar architectures (2003)

In this paper, we address the problem of generating an optimal instruction sequence S for a Directed Acyclic Graph (DAG), where S is optimal in terms of the number of registers used. We call this the Minimum Register Instruction Sequence (MRIS) problem. The motivation for revisiting the MRIS problem stems from several modern architecture innovations/requirements that has put the instruction sequencing problem in a new context. We develop an efficient heuristic solution for the MRIS problem. This solution is based on the notion of instruction lineage-a set of instructions that can definitely share a single register. The formation of lineages exploits the structure of the dependence graph to facilitate the sharing of registers not only among instructions within a lineage, but also across lineages. Our efficient heuristics to "fuse" lineages further reduce the register requirement. This reduced register requirement results in generating a code sequence with fewer register spills. We have implemented our solution in the MIPSpro production compiler and measured its performance on the SPEC95 floating point benchmark suite. Our experimental results demonstrate that the proposed instruction sequencing method significantly reduces the number of spill loads and stores inserted in the code, by more than 50 percent in each of the benchmarks. Our approach reduces the average number of dynamic loads and stores executed by 10.4 percent and 3.7 percent, respectively. Further, our approach improves the execution time of the benchmarks on an average by 3.2 percent. In order to evaluate how efficiently our heuristics find a near-optimal solution to the MRIS problem, we develop an elegant integer linear programming formulation for the MRIS problem. Using a commercial integer linear programming solver, we obtain the optimal solution for the MRIS problem. Comparing the optimal solution from the integer linear programming tool with our heuristic solution reveals that, in a very large majority (99.2 percent) of the cases, our heuristic solution is optimal. For this experiment, we used a set of 675 dependence graphs representing basic blocks extracted from scientific benchmark programs.
A Study on Fatigue Strength of Austenitic Stainless Steel for Centrifuge (2008)

For industrial centrifuges, the state of their welding areas, even with a naked-eye observation, offers potential safety problems such as inconsistent bead formation. STS304, which is used mainly in centrifuges, is made of metal alloys with chrome and nickel as the main ingredients, offering excellent corrosion resistance, thermal resistance, and high strength, and thus allowing it to be used for diverse purposes. This paper conducted tensile and fatigue tests of STS304 to improve the safety of centrifuges. In the findings, for the static behavior of the STS304 material, welded specimens increased their yield and tensile strength compared with the base test specimens, but decreased their elongation ratio. Also, the data dispersion phenomenon of welded specimens remarkably increased.
<i>In vitro</i>migration capacity of human adipose tissue-derived mesenchymal stem cells reflects their expression of receptors for chemokines and growth factors (2011)

The homing properties of adipose tissue-derived mesenchymal stem cells (AdMSCs) have stimulated intravenous applications for their use in stem cell therapy. However, the soluble factors and corresponding cellular receptors responsible for inducing chemotaxis of AdMSCs have not yet been reported. In the present study, the migration capacity of human AdMSCs (hAdMSCs) toward various cytokines or growth factors (GFs) and the expression of their receptors were determined. In a conventional migration assay, PDGF-AB, TGF-β1, and TNF-α showed the most effective chemoattractant activity. When AdMSCs were preincubated with various chemokines or GF, and then allowed to migrate toward medium containing 10% FBS, those preincubated with TNF-α showed the highest migratory activity. Next, hAdMSCs were either preincubated or not with TNF-α, and allowed to migrate in response to various GFs or chemokines. Prestimulation with TNF-α increased the migration activity of hAdMSCs compared to unstimulated hAdMSCs. When analyzed by FACS and RT-PCR methods, hAdMSCs were found to express C-C chemokine receptor type 1 (CCR1), CCR7, C-X-C chemokine receptor type 4 (CXCR4), CXCR5, CXCR6, EGF receptor, fibroblast growth factor receptor 1, TGF-β receptor 2, TNF receptor superfamily member 1A, PDGF receptor A and PDGF receptor B at both the protein and the mRNA levels. These results indicate that the migration capacity of hAdMSCs is controlled by various GFs and chemokines. Prior in vitro modulation of the homing capacity of hAdMSCs could stimulate their movement into injured sites in vivo when administered intravenously, thereby improving their therapeutic potential.
Association of Pesticide Exposure with Neurologic Dysfunction and Disease (2004)

Poisoning by acute high-level exposure to certain pesticides has well-known neurotoxic effects, but whether chronic exposure to moderate levels of pesticides is also neurotoxic is more controversial. Most studies of moderate pesticide exposure have found increased prevalence of neurologic symptoms and changes in neurobehavioral performance, reflecting cognitive and psychomotor dysfunction. There is less evidence that moderate exposure is related to deficits in sensory or motor function or peripheral nerve conduction, but fewer studies have considered these outcomes. It is possible that the most sensitive manifestation of pesticide neurotoxicity is a general malaise lacking in specificity and related to mild cognitive dysfunction, similar to that described for Gulf War syndrome. Most studies have focused on organophosphate insecticides, but some found neurotoxic effects from other pesticides, including fungicides, fumigants, and organochlorine and carbamate insecticides. Pesticide exposure may also be associated with increased risk of Parkinson disease; several classes of pesticides, including insecticides, herbicides, and fungicides, have been implicated. Studies of other neurodegenerative diseases are limited and inconclusive. Future studies will need to improve assessment of pesticide exposure in individuals and consider the role of genetic susceptibility. More studies of pesticides other than organophosphates are needed. Major unresolved issues include the relative importance of acute and chronic exposure, the effect of moderate exposure in the absence of poisoning, and the relationship of pesticide-related neurotoxicity to neurodegenerative disease.
Molecular and functional analysis of intragenic SMN1 mutations in patients with spinal muscular atrophy (2004)

The autosomal recessive spinal muscular atrophy (SMA), a neuromuscular disease and frequent cause of early death in childhood, is caused in 96% of patients by homozygous absence of the survival motor neuron gene (SMN1). The severity of the disease is mainly determined by the copy number of SMN2, a copy gene which predominantly produces exon 7-skipped transcripts and only low amount of full-length transcripts that encode for a protein identical to SMN1. Only about 4% of SMA patients bear one SMN1 copy with an intragenic mutation. A comprehensive molecular genetic analysis of 34 SMA patients who carry one SMN1 gene is presented, including 18 that were previously published. Haplotype analysis with the microsatellite markers Ag1-CA and C212 in these SMA families turned out to be a reliable accessory method in predicting known SMN1 mutations in SMA patients carrying one SMN1 copy. Five novel missense mutations were identified that are localized in: exon 2a c.88G>A (p.D30N) and c.131A>T (p.D44V); exon 3 c.283G>C (p.G95R) and c.332C>G (p.A111G); and exon 6 c.784A>G (p.S262G), respectively. The survival motor neuron (SMN) protein has been shown to be a component of a large complex (termed the SMN complex) that promotes the formation of spliceosomal U small nuclear ribonucleoproteins (snRNPs). Within this complex, SMN forms oligomers and directly interacts via its N-terminus with SMN-interacting protein 1 (SIP1) and via its central Tudor domain with spliceosomal (Sm) proteins. We performed in vitro interaction studies to test whether SMA-causing missense mutations identified in this study interfere with the reported interactions of SMN. Our results show that mutations p.G95R and p.A111G reduce SMN binding to Sm proteins, further confirming the previous finding that the Tudor domain is the essential binding site of SMN to Sm-proteins. However, all mutations, including those in exon 2a, a region shown to be important for the binding of SMN to SIP1, do not disturb the interaction of SMN to SIP1.
Synthesis of titanium-containing ZSM-48 (1992)

Titanium-containing ZSM-48 is synthesized with silicon to titanium ratios of 26 or larger; changes in unit cell volume and IR data show that titanium is incorporated into framework positions.
Noise estimation in voice signals using short-term cepstral analysis (2007)

Cepstral-based estimation is used to provide a baseline estimate of the noise level in the logarithmic spectrum for voiced speech. A theoretical description of cepstral processing of voiced speech containing aspiration noise, together with supporting empirical data, is provided in order to illustrate the nature of the noise baseline estimation process. Taking the Fourier transform of the liftered (filtered in the cepstral domain) cepstrum produces a noise baseline estimate. It is shown that Fourier transforming the low-pass liftered cepstrum is comparable to applying a moving average (MA) filter to the logarithmic spectrum and hence the baseline receives contributions from the glottal source excited vocal tract and the noise excited vocal tract. Because the estimation process resembles the action of a MA filter, the resulting noise baseline is determined by the harmonic resolution (as determined by the temporal analysis window length) and the glottal source spectral tilt. On selecting an appropriate temporal analysis window length the estimated baseline is shown to lie halfway between the glottal excited vocal tract and the noise excited vocal tract. This information is employed in a new harmonics-to-noise (HNR) estimation technique, which is shown to provide accurate HNR estimates when tested on synthetically generated voice signals.
Salt Splitting Using Ceramic Membranes (1997)

Abstract Inorganic ceramic membranes for salt splitting of radioactively contaminated sodium salt solutions are being developed for treating U.S. Department of Energy tank wastes. The process consists of electrochemical separation of sodium ions from the salt solution using sodium (Na) Super Ion Conductors (NASICON) membranes. In contrast to conventional organic-based bipolar or ion exchange membranes used in salt splitting, NaSICON membranes are resistant to gamma/beta radiation and are highly selective for sodium ions. Potential applications include 1) caustic recycle for sludge leaching, regeneration of ion exchange resins, inhibition of corrosion in carbon steel tanks, or retrieval of tank wastes; 2) pH adjustmet and reduction of competing cations to enhance cesium ion exchange processes; 3) sodium reduction in high-level waste sludges; and 4) sodium removal from acidic wastes to facilitate calcining. Initial experiments with dysprosium-based NaSICON membranes have demonstrated the feasibility of the process.
The Vav Binding Site (Y315) in ZAP-70 Is Critical for Antigen Receptor–mediated Signal Transduction (1997)

Stimulation of antigen receptors in T and B cells leads to the activation of the Src and Syk families of protein tyrosine kinases (PTK). These PTKs subsequently phosphorylate numerous intracellular substrates, including the 95-kD protooncogene product Vav. Vav is essential for both T and B cell development and T and B cell antigen receptor–mediated signal transduction. After receptor ligation, Vav associates with phosphorylated Syk and ZAP-70 PTKs, an interaction that depends upon its SH2 domain. Here we demonstrate that a point mutation of tyrosine 315 (Y315F) in ZAP-70, a putative Vav SH2 domain binding site, eliminated the Vav– ZAP-70 interaction. Moreover, the Y315 mutation impaired the function of ZAP-70 in antigen receptor signaling. Surprisingly, this mutation also resulted in marked reduction in the tyrosine phosphorylation of ZAP-70, Vav, SLP-76, and Shc. These data demonstrate that the Vav binding site in ZAP-70 plays a critical role in antigen receptor–mediated signal transduction.
Analysis and elimination of voltage imbalance between the split capacitors in half-bridge boost rectifiers (2002)

The voltage imbalance between the split capacitors in a halfbridge boost rectifier is reviewed in this letter. It can be proven that the optimal compensation strategy is to add only a DC component in the source current. The adverse effects of the imbalance elimination control loop to the input power factor are studied. The analytical results are verified through experiments.
A WAVELET PACKETS TECHNIQUE FOR THE DETECTION OF ANOMALIES IN FOURIER TRANSFORM INFRARED INTERFEROGRAMS (2002)

A technique that integrates applications of wavelet packets and principal component analysis is developed. This technique is applied for the purpose of detecting anomalies in Fourier Transform Infrared (FTIR) interferograms. An experimental example is given to demonstrate the performance of this technique.
Systemic glucocorticoids decrease the synthesis of type I and type III collagen in human skin in vivo, whereas isotretinoin treatment has little effect (1994)

The effects of systemic glucocorticoid and isotretinoin treatments on type I and type III collagen synthesis in intact skin were investigated by measuring the carboxyterminal and aminoterminal propeptides of type I procollagen, and the aminoterminal propeptide of type III procollagen, in suction blister fluid (SBF), in a study of 27 patients. All three parameters were significantly lower in the SBF of glucocorticoid-treated patients than in controls or patients undergoing treatment with isotretinoin, whereas the latter two groups did not differ significantly from each other. During glucocorticoid treatment, the concentrations of the procollagen propeptides were only about 20% of the corresponding control values, indicating that systemic therapy with prednisone at a dose of 0.48 mg/kg per day almost totally abolishes collagen synthesis in the skin. These results indicate that systemic glucocorticoid treatment suppresses the synthesis of both type I and type III collagen in the dermis, and suggest that many side-effects of these drugs, such as atrophy of the skin, are due to this inhibition. Systemic isotretinoin treatment did not stimulate skin collagen synthesis. Thus, its regenerative effect on connective tissue may be mediated by mechanisms other than direct stimulation of collagen synthesis.
A Novel Protein Tightly Bound to Bacterial Magnetic Particles in Magnetospirillum magneticum Strain AMB-1 (2003)

Magnetic bacteria synthesize magnetite crystals with species-dependent morphologies. The molecular mechanisms that control nano-sized magnetite crystal formation and the generation of diverse morphologies are not well understood. From the analysis of magnetite crystal-associated proteins, several low molecular mass proteins tightly bound to bacterial magnetite were obtained from Magnetospirillum magneticum strain AMB-1. These proteins showed common features in their amino acid sequences, which contain hydrophobic N-terminal and hydrophilic C-terminal regions. The C-terminal regions in Mms5, Mms6, Mms7, and Mms13 contain dense carboxyl and hydroxyl groups that bind iron ions. Nano-sized magnetic particles similar to those in magnetic bacteria were prepared by chemical synthesis of magnetite in the presence of the acidic protein Mms6. These proteins may be directly involved in biological magnetite crystal formation in magnetic bacteria.
Velocity model building with a modified fully convolutional network (2018)

We introduce a machine learning based method to estimate the P-wave velocity models directly from the prestack seismic traces using a modified fully convolutional network. The network is tuned to map multi-shot seismic traces to velocity models. We train the network with pairs of synthetic velocity models and their corresponding multi-shot seismic traces which are simulated from the velocity models with acoustic wave equations. Multiple shots are used as channels in the network to increase data redundancy. The training process is expensive, but it only occurs once up front. The trained network is then used to predict velocity models from testing seismic traces, and it shows satisfactory prediction results. The cost for predicting velocity models is negligible once the training is complete. Presentation Date: Wednesday, October 17, 2018 Start Time: 1:50:00 PM Location: 204B (Anaheim Convention Center) Presentation Type: Oral