gebhart/patrepeval huggingface dataset:
Efficacy of Combination Therapy of Statin and Vitamin C in Comparison with Statin in the Prevention of Post-CABG Atrial Fibrillation (2013)

Based on our findings, combination prophylaxis against post CABG AF with oral atorvastatin plus vitamin C is significantly more effective than single oral atorvastatin.
Automatic Countercurrent Distribution Equipment (1951)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAutomatic Countercurrent Distribution EquipmentL. C. Craig, Werner Hausmann, E. H. Ahrens, Jr., and E. J. HarfenistCite this: Anal. Chem. 1951, 23, 9, 1236–1244Publication Date (Print):September 1, 1951Publication History Published online1 May 2002Published inissue 1 September 1951https://pubs.acs.org/doi/10.1021/ac60057a009https://doi.org/10.1021/ac60057a009research-articleACS PublicationsRequest reuse permissionsArticle Views169Altmetric-Citations103LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Erythromycin and diffuse panbronchiolitis. (1997)

Ion Transport Unit, resistant to bronchodilators than that of chronic lations and thus suggesting some genetic National Heart and Lung Institute, obstructive pulmonary disease. 5 component to the disease.However, this as- Imperial College,The disease has been reported to be more sociation is yet to be confirmed.In addition, Manresa Road,prevalent in men and most have never smoked.a relatively small number of familial cases has London SW3 6LR, UK H KoyamaThe peak incidence occurs in the fifth and sixth been reported thus far, 20 though it is not undecades, 6 though it can occur at any age of usual that some of the siblings of the patients Department of adult life. 7 The titre of the cold haemagglutinin have chronic sinusitis without chest lesions. RespiratoryMedicine, Royal Brompton is raised in most patients, 8 and the changes in Based on a detailed observation of a single Hospital, the titre reflect the therapeutic response to case, Kudoh et al noticed that erythromycin Sydney Street, some extent.Other laboratory abnormalities might be effective in treating patients with DPB London SW3 6NP, UK include raised erythrocyte sedimentation rate, and performed an open trial which showed D M Geddes positive C reactive protein (CRP) and positive the beneficial effect of low dose, long term
Different non-pharmacological approaches for management of type 2 diabetes (2013)

Diabetes mellitus is a syndrome characterized by chronic hyperglycemia, due to absolute or relative deficiency or diminished effectiveness of circulating insulin. It is the most common serious metabolic disease. Diabetes mellitus has been recognized as a clinical syndrome since ancient times and remains a crippling global health problem today. Diabetes may be divided into type 1 and type 2. Type 1 diabetes is caused by deficiency of insulin production, while type 2 diabetes is characterized by insulin resistance. The high medicinal treatment cost of diabetes, has led to a growing interest in alternative therapies for diabetes management. All the findings of this review paper highlighted the effectiveness of medicinal plants, the effectiveness of exercise therapy, diet and other lifestyle treatments for preventing type 2 diabetes and reducing mortality and morbidity among persons who are at an increased risk of developing the disease.
Neuroprotection in Ischemic Mouse Brain Induced by Stem Cell-Derived Brain Implants (2006)

Protective mechanisms of the brain may reduce the extent of injury after focal cerebral ischemia. Here, we explored in a mouse model of focal cerebral ischemia potential synergistic neuroprotective effects of two mediators of neuroprotection: (i) neuronal or glial precursor cells and (ii) the inhibitory neuromodulator adenosine. Embryonic stem (ES) cells, engineered to release adenosine by biallelic disruption of the adenosine kinase gene, and respective wild-type cells were induced to differentiate into either neural or glial precursor cells and were injected into the striatum of mice 1 week before middle cerebral artery occlusion. All stem cell-derived graft recipients were characterized by a significant reduction in infarct volume, an effect that was augmented by the release of adenosine. Neuroprotection was strongest in adenosine-releasing glial precursor cell recipients, which were characterized by an 85% reduction of the infarct area. Graft-mediated neuroprotection correlated with a significant improvement of general and focal neurologic scores. Histologic analysis before and after ischemia revealed clusters of implanted cells within the striatum of all treated mice. We conclude that ES cell derived adenosine-releasing brain implants provide neuroprotection by synergism of endogenous precursor cell-mediated effects and paracrine adenosine release.
Pharmacology of Phosphoinositides, Regulators of Multiple Cellular Functions (2001)

Inositol phospholipids represent a small fraction of the phospholipids present in all cellular membranes with remarkable importance in regulating various cell functions. They are synthesized from phosphatidylinositol by sequential phosphorylations on the several hydroxyls of the inositol ring to create polyphosphoinositides that function either as docking sites to promote formation of molecular signaling complexes, or serve as precursors for soluble inositol polyphosphates that act as diffusible intracellular messengers. Phosphoinositides are involved in the control of many processes, including membrane traffic, endo- and exocytosis, mitogenesis and apoptosis. Pharmacological tools have helped to clarify many details of phosphoinositide metabolism and have unveiled the roles of these lipids in the control of specific signaling pathways. However, because of their pleiotropic functions it has been questionable whether pharmacological manipulation of inositide formation and metabolism can be of therapeutic value. This review briefly summarizes the means by which inositide functions have been pharmacologically manipulated, and discusses possibilities for specifically targeting certain aspects of their regulatory functions.
Replication-Competent Ad11p Vector (RCAd11p) Efficiently Transduces and Replicates in Hormone-Refractory Metastatic Prostate Cancer Cells (2009)

Selective replication-competent adenovirus serotype 5 vectors have been used for prostate cancer therapy. Unfortunately, gene transfer is inefficient because hormone-refractory metastatic prostate cancer cells have minimal coxsackievirus-adenovirus receptor expression. Vectors based on species B adenoviruses are attractive tools for use in human gene therapy because the viruses have low seroprevalence and they have efficient transduction capacity. Most species B adenoviruses use ubiquitously expressed complement-regulatory CD46 protein as a cellular receptor. Here we report the transduction efficacy and oncolytic capacity of a replication-competent Ad11p (RCAd11p) vector in human prostate cancer cells. Green fluorescent protein was efficiently expressed in a dose-dependent manner in PC-3 and DU 145 cells derived from metastasis of prostate cancer to bone and brain, respectively. However, transduction was less effective in LNCaP cells derived from prostate cancer metastasis to lymph nodes. The oncolytic capacity of the RCAd11p vector was 100 times higher in PC-3 cells than in the two other cell lines. The oncolysis was independent of the level of expression of p53 in the cells or on the absence of E1B55k expression in the vector. In vivo experiments revealed significant growth inhibition of PC-3 tumors in the xenograft mouse group treated with RCAd11p vector or Ad11pwt in comparison with the untreated control group. Thus, we have demonstrated that RCAd11p vector intrinsically possesses oncolytic properties, which were active in targeting tumor cells. Consequently, the novel RCAd11p vector has great potential for the treatment of incurable metastatic prostate disease.
Fatigue characteristics of McKibben artificial muscle actuators (2002)

The McKibben artificial muscle is a pneumatic actuator whose properties include a very high force to weight ratio. This characteristic makes it very attractive for a wide range of applications such as mobile robots and prosthetic appliances for the disabled. Typical applications often require a significant number of repeated contractions and extensions or cycles of the actuator. This repeated action leads to fatigue and failure of the actuator, yielding a life span that is often shorter than its more common robotic counterparts such as electric motors or pneumatic cylinders. In this paper, we develop a model that predicts the maximum number of life cycles of the actuator based on available uniaxial tensile properties of the actuator's inner bladder. Experimental results, which validate the model, reveal McKibben actuators fabricated with natural latex rubber bladders have a fatigue limit 24 times greater than actuators fabricated with synthetic silicone rubber at large contraction ratios.
Pancreatic Mesenchyme Regulates Epithelial Organogenesis throughout Development (2011)

The developing pancreatic epithelium gives rise to all endocrine and exocrine cells of the mature organ. During organogenesis, the epithelial cells receive essential signals from the overlying mesenchyme. Previous studies, focusing on ex vivo tissue explants or complete knockout mice, have identified an important role for the mesenchyme in regulating the expansion of progenitor cells in the early pancreas epithelium. However, due to the lack of genetic tools directing expression specifically to the mesenchyme, the potential roles of this supporting tissue in vivo, especially in guiding later stages of pancreas organogenesis, have not been elucidated. We employed transgenic tools and fetal surgical techniques to ablate mesenchyme via Cre-mediated mesenchymal expression of Diphtheria Toxin (DT) at the onset of pancreas formation, and at later developmental stages via in utero injection of DT into transgenic mice expressing the Diphtheria Toxin receptor (DTR) in this tissue. Our results demonstrate that mesenchymal cells regulate pancreatic growth and branching at both early and late developmental stages by supporting proliferation of precursors and differentiated cells, respectively. Interestingly, while cell differentiation was not affected, the expansion of both the endocrine and exocrine compartments was equally impaired. To further elucidate signals required for mesenchymal cell function, we eliminated β-catenin signaling and determined that it is a critical pathway in regulating mesenchyme survival and growth. Our study presents the first in vivo evidence that the embryonic mesenchyme provides critical signals to the epithelium throughout pancreas organogenesis. The findings are novel and relevant as they indicate a critical role for the mesenchyme during late expansion of endocrine and exocrine compartments. In addition, our results provide a molecular mechanism for mesenchymal expansion and survival by identifying β-catenin signaling as an essential mediator of this process. These results have implications for developing strategies to expand pancreas progenitors and β-cells for clinical transplantation.
Protecting polymers in suspension of metal nanoparticles (2001)

Abstract Poly( N ‐vinyl‐2‐pyrrolidone) (PVP) was chosen as a protecting polymer for its large protective value among homopolymers. Suspensions of palladium (Pd) nanoparticles were prepared by refluxing solutions of palladium(II) chloride and PVP in methanol. The mean diameter of Pd nanoparticles without adsorbed layer of PVP was controlled in the range 1.1–2.5 nm. The concentration of free PVP in the methanol suspension was determined by using aminoethylated poly(acrylamide) gel beads which adsorbed selectively the PVP‐protected Pd nanoparticles. The amount of PVP adsorbed on Pd nanoparticles increased linearly with the 0.45 power of weight‐averaged molecular weight ( M w ) of PVP. The thickness of adsorbed layer of PVP was estimated from the sedimentation coefficient of the PVP‐protected Pd nanoparticles. The adsorbed layer thickness increased linearly with the 0.55 power of M w of PVP. The radius gyration of free PVP in methanol increased linearly also with the 0.55 power of M w of PVP. The catalytic activity of the suspension of Pd nanoparticles was determined in the hydrogenation of 1,3‐cyclooctadiene. The activity depended more effectively on the specific surface area of Pd nanoparticles than the adsorbed layer thickness. On the basis of these results, the conformation of protecting PVP molecule on the surface of Pd nanoparticles was proposed. Copyright © 2001 John Wiley & Sons, Ltd.
Vaccination with a Fusion Protein That Introduces HIV-1 Gag Antigen into a Multitrimer CD40L Construct Results in Enhanced CD8 <sup>+</sup> T Cell Responses and Protection from Viral Challenge by Vaccinia-Gag (2013)

CD40 ligand (CD40L, CD154) is a membrane protein that is important for the activation of dendritic cells (DCs) and DC-induced CD8(+) T cell responses. To be active, CD40L must cluster CD40 receptors on responding cells. To produce a soluble form of CD40L that clusters CD40 receptors necessitates the use of a multitrimer construct. With this in mind, a tripartite fusion protein was made from surfactant protein D (SPD), HIV-1 Gag as a test antigen, and CD40L, where SPD serves as a scaffold for the multitrimer protein complex. This SPD-Gag-CD40L protein activated CD40-bearing cells and bone marrow-derived DCs in vitro. Compared to a plasmid for Gag antigen alone (pGag), DNA vaccination of mice with pSPD-Gag-CD40L induced an increased number of Gag-specific CD8(+) T cells with increased avidity for major histocompatibility complex class I-restricted Gag peptide and improved vaccine-induced protection from challenge by vaccinia-Gag virus. The importance of the multitrimeric nature of the complex was shown using a plasmid lacking the N terminus of SPD that produced a single trimer fusion protein. This plasmid, pTrimer-Gag-CD40L, was only weakly active on CD40-bearing cells and did not elicit strong CD8(+) T cell responses or improve protection from vaccinia-Gag challenge. An adenovirus 5 (Ad5) vaccine incorporating SPD-Gag-CD40L was much stronger than Ad5 expressing Gag alone (Ad5-Gag) and induced complete protection (i.e., sterilizing immunity) from vaccinia-Gag challenge. Overall, these results show the potential of a new vaccine design in which antigen is introduced into a construct that expresses a multitrimer soluble form of CD40L, leading to strongly protective CD8(+) T cell responses.
Effect of Carboxylate Ligands on Alkane Dehydrogenation with (<sup><i>dm</i></sup>Phebox)Ir Complexes (2018)

A series of carboxylate-ligated iridium complexes (dmPhebox)Ir(O2CR)2(H2O) (R = −CH3, −CH2CH3, −CMe3, −CH2C6H5, and −CH═CMe2) were designed and synthesized to understand the carboxylate ligand effects on the reactivity of the complex for alkane dehydrogenation. Kinetic studies showed that the different R groups of the carboxylate iridium complexes can affect the reactivity with octane in the β-H elimination step. The rate constants for octene formation with different carboxylate ligands follow the order R = −CH═CMe2 > −CMe3 > −CH2CH3 > −CH3 > −CH2C6H5. In contrast, there is no significant effect of carboxylate ligand on the rate of the C–H activation step at 160 °C. These experimental results support the findings in the previously reported density functional theory study of the (dmPhebox)Ir complex in alkane C–H activation.
Iron Porphyrin-Catalyzed Reduction of CO<sub>2</sub>. Photochemical and Radiation Chemical Studies (1997)

Several iron porphyrins have been reduced by photochemical and radiation chemical methods, in organic solvents and in aqueous solutions, from FeIIIP to FeIIP to FeIP and beyond. In aqueous solutions, the FeIP state is relatively stable for the tetrakis(N-methyl-2-pyridyl)porphyrin at high pH but is shorter lived in neutral and acidic solutions. The FeIP state of tetrakis(N-methyl-3-pyridyl)porphyrin and tetrakis(N-methyl-4-pyridyl)porphyrin are short-lived at any pH. Decay of FeIP is accelerated by H+ and by CO2, probably via reaction with the Fe0P state formed upon disproportionation of FeIP. These reactions may lead to formation of H2 and CO, respectively, and to formation of the chlorin, FeIIPH2, as a side product. The FeIP state is also observed as a stable product in several organic solvents. This is observed by photolysis of iron tetraphenylporphyrin and several of its derivatives (e.g., trimethyl-, dichloro- and pentafluorophenyl), mainly in dimethylformamide and acetonitrile solutions, using triethylamine as a reductive quencher. Further photoreduction in the presence of CO2 results in catalyzed reduction of CO2 to CO and formation of (CO)FeIIP. The yield of free CO increases with time of photolysis and reaches turnover numbers of ∼70 molecules of CO per porphyrin molecule.
Single-molecule counting of biomolecules with femtoliter dropret chamber array (2013)

We attempted to develop a novel digital counting method to measure the number of target biomolecules at a single molecule level by use of an array of one million femtoliter water-in-oil (W/O) droplet. Target molecules were first captured on antibody-modified microbeads after labeled with reporter enzyme. After beads were entrapped individually in micron-sized w/o droplets of which volume are femtoliter scale, fluorogenic enzyme assay was carried out to count the number of captured target molecules. As a demonstration, enzyme-linked immunosorbent (ELISA) assay of prostate specific antigen was conducted. The limit of detection of prostate specific antigen reached 2 aM, ten million times enhanced compared with conventional ELISA.
Reducing Implant Infection in Orthopaedics (RIIiO): a pilot study for a randomised controlled trial comparing the influence of forced air versus resistive fabric warming technologies on postoperative infection rates following orthopaedic implant surgery in adults (2018)

ISRCTN, ISRCTN74612906 . Registered on 27 February 2017.
General system for normal and phonetic inflection (2009)

Generating all inflected forms for a natural language is a very difficult task not only because of the large number of inflection rules but also because of the large number of exceptions. The operation is more difficult if we consider not only the normal inflected forms (where the inflected forms are represented in the normal alphabet of the involved language) but also the phonetic forms (where the inflected forms are represented in a phonetic alphabet). This paper presents a general system (i.e. a system that can be used for any inflected natural language) that generates all the normal and phonetic forms of words from a given lexicon. A set of results obtained by using this system for Romanian language is also presented. The system is based on GRAALAN metalanguage (grammar abstract language) used for representing the linguistic knowledge concerning a natural language and requested by the inflection process. It also uses a set of tools that allows the handling of this (meta) language. The system starts with a set of linguistic knowledge bases described in GRAALAN containing: normal and phonetic inflection rules, the description of the normal and phonetic alphabets that are used, the base forms (lemmas) that will be inflected, taken from a lexicon (also in normal and phonetic forms) and the description of the morphological structure of the language (morphological categories and their values). All these linguistic knowledge bases are created using special tools. The inflected normal/phonetic forms will be automatically generated by applying the normal/phonetic inflection rules on the lemmas of the lexicon, taking into account the morphological structure and the normal/phonetic alphabets. At the end of the process, the linguist is able to verify and eventually correct the generated forms. When corrections are made, new inflection rules are automatically generated. The presented system is part of larger system for natural language processing.
Design of a 4-MHz analog integrated CMOS transconductance-C bandpass filter (1988)

A continuous-time eighth-order fully integrated CMOS transconductance-C bandpass filter is presented for operation at 4 MHz with 800 kHz bandwidth and 0.5 dB pass-band ripple. A phase-locked loop for frequency tuning and four-point amplitude-locking loop for Q-factor tuning at the reflection zeros of the filter are implemented. The transfer characteristics were found to be essentially within specifications: less than 1-dB passband attenuation, 75-dB stopband attenuation and S/N ratio, and 0.5% harmonic distortion for 0.5-V/sub p-p/ signal were observed. Offset of the transconductances was internally controlled by an offset-control loop to less than 4 mV. A temperature-insensitive transconductance design and the noise characteristics of the filter building blocks are also discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Cationic polymerization of 4‐ethyl‐1,3‐dioxolane (1976)

Abstract The bulk polymerization of 4‐ethyl‐1,3‐dioxolane, ( 1 ), was investigated at temperatures ranging from −48 to 0°C with boron trifluoride etherate and the perchloric acid/acetic anhydride binary system as initiators. At temperatures above − 20°C, liquid oligomers were obtained in poor yield, while at lower temperatures viscous polymer consisting of alternating sequences of oxy‐1‐ethylethylene and oxymethylene units with number average molecular weights of several thousands was produced. 1 H NMR analysis of the acetal protons of the polymer on the basis of some model compounds disclosed that the bond cleavage of the monomer in the polymerization occurred nearly randomly at the two acetal C–‐O bonds. This polymerization involves a monomer‐polymer equilibrium. The thermodynamic parameters for the polymerization were determined from the temperature dependence of the equilibrium monomer concentrations: Δ H 1c = −13,0±0,8 kJ mol −1 (= −3,1±0,2 kcal/mol) and Δ S 1c = −59,4±3,8 J mol −1 K −1 (= −14,2±0,9 cal/(mol K)). 4‐Isopropyl‐1,3‐dioxolane, ( 2 ), was found very reluctant to polymerize above − 78°C.