gebhart/patrepeval huggingface dataset:
Peripheral blood T cells and monocytes and B cell lines derived from patients with lupus express estrogen receptor transcripts similar to those of normal cells. (1998)

Monocytes, T cells, and B cells in patients express transcripts of the normal wild type ER and the hormone binding domain variants in vivo.
Sequence analysis of cDNA and genomic DNA for a putative pertussis toxin-insensitive guanine nucleotide-binding regulatory protein alpha subunit. (1988)

We have isolated cDNA clones from rat C6 glioma cells coding for several guanine nucleotide-binding regulatory protein (G protein) alpha subunits (G alpha). The cDNA clones were then used to isolate human chromosomal genes. Among human genomic clones isolated by cross-hybridization with the rat cDNA for the alpha subunit of the inhibitory G protein Gi2, termed Gi2 alpha, a clone designated lambda HGi62 was found to contain a sequence that is highly homologous but distinct from any of the known G alpha sequences, and we have tentatively designated this sequence Gx alpha. We have searched a rat brain cDNA library with the Gx alpha sequence and isolated a cDNA clone containing a rat sequence similar to human Gx alpha. The cDNA contained a single open reading frame of 1065 nucleotides coding for a protein of 355 amino acids with a calculated molecular weight of 40,879. The amino acid sequence of rat Gx alpha shows 66% and 40% similarity with rat Gi2 alpha and rat Gs alpha (the alpha subunit of the stimulatory G protein), respectively. By RNA blot hybridization analysis, mRNA of approximately 3.2 kilobases was detected mainly in brain. Interestingly, the deduced amino acid sequence of Gx alpha predicts that the Gx alpha protein may be refractory to modification by pertussis toxin since the cysteine residue in the fourth position from the C terminus of pertussis toxin-sensitive G alpha is replaced by isoleucine.
Active and Tissue Inhibitor of Matrix Metalloproteinase-free Gelatinase B Accumulates within Human Microvascular Endothelial Vesicles (1998)

Human gelatinase B is involved in tissue remodeling and angiogenesis. It is thought to be synthesized and rapidly secreted as an inactive precursor. In this report, we have shown that human endothelial cells accumulate active forms of gelatinase B in the cytosol. Microvascular but not macrovascular endothelial cells dramatically increased the expression of cytosolic gelatinase B in response to phorbol myristate acetate. Western blotting showed that tissue inhibitor of metalloproteinase-1 (TIMP1) was also present in the cytosol. Whereas gelatinase B was complexed with TIMP1 in the conditioned medium, it existed as a free enzyme in the cytosol, suggesting that the formation of gelatinase B and TIMP1 complex occurs after their secretion. Immunogold electron microscopy revealed that gelatinase B was localized in secretory vesicles which were especially prominent in invading pseudopodia. In contrast, TIMP1 was found throughout the cytoplasm but was not present in the gelatinase vesicles. The accumulation of intracellular activated gelatinase B, ready for rapid release, may facilitate the migration of microvascular endothelial cells during angiogenesis.
Modeling Considerations for <sup>11</sup>C-CUMI-101, an Agonist Radiotracer for Imaging Serotonin 1A Receptor In Vivo with PET (2008)

On the basis of the measurable free fraction, high affinity and selectivity, adequate blood-brain permeability, and favorable plasma and brain kinetics, 11C-CUMI-101 is an excellent candidate for imaging high-affinity 5-HT1ARs in humans.
Organomagnesates from Reactions of Dialkylmagnesium Compounds with Alkali-Metal Alkoxides, Potassium Hydride, and Other Salts (2004)

Reactions of R2Mg and KOR‘ in benzene form solutions containing organomagnesates that incorporate equal amounts of the reactants. NMR spectra of preparations in which the choice of R and R‘ leads to stereoisomers are consistent with a dimeric organomagnesate structure in which the magnesium atoms of two R2Mg units are bridged by the oxygen atoms of two OR‘ groups. Similar species result when NaOR‘ is the salt or diethyl ether is the solvent. When less than 1 equiv of KOR‘ is used, other species also are present. Reactions in benzene of R2Mg with some other salts, including tetrabutylammonium halides and LiNR‘2 compounds, also furnish 1:1 organomagnesates, but reactions with KH can lead to solutions of R3MgK.
Efficient scrambling of wavelet-based compressed images (2006)

Image scrambling is a fundamental task for several applications, from secure digital content transmission to mutual visual authentication. This paper proposes and evaluates several simple techniques with the aim of being efficient in respect to wavelet compression algorithms and fit for mobile applications. Then, the proposed methods are meant to comply with the average structure of wavelet-based coders and require very low computational capacity. Comparative results are provided both for evaluating the scrambling efficacy and the computational complexity.
Transformation of Lignin-Derived Aromatics into Nonaromatic Polymeric Substances with Fluorescent Activities (NAPSFA) by <i>Pseudomonas</i> sp. ITH-SA-1 (2015)

We examined bacteria capable of transforming lignin-derived compounds into industrially or economically valuable substances from the seawater after the Great East Japan Earthquake-caused tsunami. Pseudomonas sp. ITH-SA-1 produced water-soluble fluorescent substances from the lignin-derived aromatic, syringaldehyde (SYAL). They: are polymeric substances derived from 3-O-methyl gallate produced through transformation of SYAL via syringate; are not known compounds reported previously; have excitation/emission peaks at 365/498 nm, respectively; and have an average molecular weight of 7.2 kDa. Despite the fact that aromatic structure generally plays an important role in the planarity and rigidity of organic fluorescent substance, the spectroscopic analyses revealed that aromatic rings were not detected in the molecules. Their activity is particularly rare and the biotransforming capabilities will contribute to the development of new basic techniques for the effective utilization of lignin.
Correction of Optical Aberrations by Neutron Irradiation (1971)

The refractive index of optical materials can be modified by means of neutron irradiation. By varying the radiation dose over selected areas of a lens according to some given law, the local change in the refractive index can be adjusted to correct for different types of optical aberrations. The particular case of spherical aberration is treated in detail. It is shown that irradiation leads to index modifications of the required order of magnitude and that irradiation times are acceptable. Moreover, the stability of the index modifications, the possibility of bleaching-without curing the index-and the absence of residual radioactivity make an irradiated lens suitable for optical applications. The optician has thus at his disposal a new parameter.
Machine Vision Algorithms (2017)

This chapter discusses the most important machine vision algorithms. It discusses several segmentation algorithms. They have in common that they are based on thresholding the image, with either pixel or subpixel accuracy. The goal of a robust segmentation algorithm must be to find the boundary of the objects as robustly and accurately as possible. The best way to describe the boundaries of the objects robustly is by regarding them as edges in the image. Mathematical morphology provides a set of extremely useful operations that enable us to modify or describe the shape of objects. Morphological operations can be defined on regions and gray value images. The chapter discusses both types of operations. Optical Character Recognition is the process of reading characters in images. It consists of two tasks: segmentation of the individual characters, and the classification of the segmented characters. The chapter examines these two tasks.
Manipulation of Colloids by a Nonequilibrium Depletion Force in a Temperature Gradient (2009)

The nonequilibrium distribution of colloids in a polymer solution under a temperature gradient is studied experimentally. A slight increase of local temperature by a focused laser drives the colloids towards the hot region, resulting in the trapping of the colloids irrespective of their own thermophoretic properties. An amplification of the trapped colloid density with the polymer concentration is measured, and is quantitatively explained by hydrodynamic theory. The origin of the attraction is a migration of colloids driven by a nonuniform polymer distribution sustained by the polymer's thermophoresis. These results show how to control the thermophoretic properties of colloids.
Inactivation of lymphocyte-transforming activity of human T-cell leukemia virus type I by heat. (1986)

Peripheral blood lymphocytes from 2 normal individuals seronegative for human T-cell leukemia virus type I (HTLV-I) were co-cultured with HTLV-I-producing MT-2 cells that had been heated at 56 degrees for 30 min or exposed to 10,000 rad of X-irradiation. HTLV-I-induced lymphocyte transformation was consistently achieved by co-culture with irradiated MT-2 cells but not by co-culture with heated MT-2 cells. The heat treatment was found to be lethal to both MT-2 cells and the virus. These findings are discussed in terms of their potential clinical application for preventing the transmission of HTLV-I.
Antibacterial properties of the leaf extract of<i>Mentha arvensis</i>L. (2011)

The antibacterial activity of methanolic and aqueous leaf extracts of Mentha arvensis L. (Family: Lamiaceae) has been tested against five strains of human pathogenic bacteria namely Escherichia coli, Pseudomonas aeruginosa, Shigella flexineri, Klebsiella pneumoniae and Staphylococcus aureus. Both methanolic and aqueous extracts did not effect the growth of E.coli. Staphylococcus aureus and Shigella flexineri were not affected by the aqueous extracts, but influenced by methanolic extracts. Methanolic and aqueous extracts had shown their effect in concentrations ranging from1.25% to 10% and 2.5% to 10%, respectively on selected bacteria. The antibacterial activity was more significant against Shigella flexineri, i.e., 14 mm zone by methanol extract and Klebsiella pneumonia, i.e., 10 mm zone by aqueous extract.
Gingival Recession, Gingival Bleeding, and Dental Calculus in Adults 30 Years of Age and Older in the United States, 1988‐1994 (1999)

Dental calculus, gingival bleeding, and gingival recession are common in the U.S. adult population. In addition to their unfavorable effect on esthetics and self-esteem, these conditions also are associated with destructive periodontal diseases and root caries. Appropriate measures to prevent or control these conditions are desirable, and this may also be effective in improving the oral health of the U.S. adult population.
Extremely robust and conformable capacitive pressure sensors based on flexible polyurethane foams and stretchable metallization (2013)

Microfabricated capacitive sensors prepared with elastomeric foam dielectric films and stretchable metallic electrodes display robustness to extreme conditions including stretching and tissue-like folding and autoclaving. The open cellular structure of the elastomeric foam leads to significant increase of the capacitance upon compression of the dielectric membrane. The sensor sensitivity can be adjusted locally with the foam density to detect normal pressure in the 1 kPa to 100 kPa range. Such pressure transducers will find applications in interfaces between the body and support surfaces such as mattresses, joysticks or prosthetic sockets, in artificial skins and wearable robotics.
Investigation of self-healing compliant actuators for robotics (2015)

Last 15 years, a wide range of self-healing (SH) materials has been developed and recently these materials are increasingly used in applications in multiple fields, like the automotive industry and aerospace. However, so far this material technology is not yet explored in robotics. The introduction of these materials in robotics will potentially reduce the over-dimensioning of current robotic systems, leading to lighter systems and eventually to more efficient designs. Compliant elements used in next generation soft robots, can be constructed from available SH-materials, making them able to autonomously heal cuts and perforations caused by sharp objects in unstructured environments. In addition, the use of SH-materials will have a beneficial impact on the life span of robotic components, reducing the required maintenance drastically. This paper presents the innovative concept of implementing a SH-mechanism in compliant actuators, using dynamic covalent polymer network systems based on the reversible Diels-Alder (DA) reaction. For two entirely different compliant actuators, a series elastic actuator (SEA) and a soft pneumatic actuator (SPA), an analysis is presented on the integration of the DA-polymers in the actuator designs. For both actuator types, a prototype was designed, developed and validated.
Effect of feeding different levels of green maize on performance of lactating crossbred cows (2007)

Lactating crossbred cows (16; 408.2 kg BW; producing 8.3 kg milk/d; in 3rd lactation) divided into four equal groups were offered concentrate mixture ad lib. wheat straw (T1) supplemented with either 10 (T2), 20 (T3) or 40 kg maize (T4) per day for 90 days. The moment nutrient intake was higher (P<0.05) in T4 than that of T2 and T1 groups. The nutrient intake was similar in T4 and T3 groups. The digestibility of CF and EE was higher in T4 as cotnpared to T2 and T1. There was non-significant difference for CF digestibility between T3 and T2. The EE digestibility was significantly (P<0.05) higher in T4. However, a nonsignificant difference was observed between T3 and T1; T4 and T3 for EE digestibility. Digestibility of other nutrients and nutritive value was comparable. The daily milk yield and fat percent was significantly higher (P<0.05) in T4 group as compared to other three groups. It was concluded that feeding higher amount of green maize to lactating crossbred cows may enhance the nutrient utilization, milk yield and composition.
Effects of Molecular Siting and Adsorbent Heterogeneity on the Ideality of Adsorption Equilibria (2004)

The ideal adsorbed solution (IAS) theory is the benchmark for the prediction of mixed-gas adsorption equilibria from pure-component isotherms. In this work, we use atomistic grand canonical Monte Carlo simulations to test the effects of molecular siting and adsorbent energetic heterogeneity on the applicability of the IAS theory. Pure-component isotherms generated by atomistic simulation are used to predict binary isobaric isotherms using the IAS theory. These predicted isotherms are compared with those obtained by a full atomistic simulation of the binary mixture. Binary mixtures of argon, methane, and CF4 in silicalite are found to obey IAS theory, while benzene/methane and cyclohexane/methane in silicalite are nonideal. The mixture of argon and CF4 is ideal despite the large difference in the sizes of the two species. This contradicts previous hypotheses in the literature, which state that mixtures of species of unequal size do not adsorb ideally. The nonideal behavior of the benzene/methane and cyclohexane/methane systems occurs because of adsorbent heterogeneity in these systems, which depends on both sorbent and sorbate. In addition, we use a lattice gas model with parameters derived from atomistic simulation to demonstrate analytically that a sufficiently energetically heterogeneous adsorbent will result in the breakdown of IAS theory even in the absence of interactions between sorbates.
Indium-Mediated Coupling of .alpha.-(Bromomethyl)acrylic Acid with Carbonyl Compounds in Aqueous Media. Concise Syntheses of (+)-3-Deoxy-D-glycero-D-galacto-nonulosonic Acid and N-Acetylneuraminic Acid (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIndium-Mediated Coupling of .alpha.-(Bromomethyl)acrylic Acid with Carbonyl Compounds in Aqueous Media. Concise Syntheses of (+)-3-Deoxy-D-glycero-D-galacto-nonulosonic Acid and N-Acetylneuraminic AcidTak-Hang Chan and Ming-Chao LeeCite this: J. Org. Chem. 1995, 60, 13, 4228–4232Publication Date (Print):June 1, 1995Publication History Published online1 May 2002Published inissue 1 June 1995https://pubs.acs.org/doi/10.1021/jo00118a044https://doi.org/10.1021/jo00118a044research-articleACS PublicationsRequest reuse permissionsArticle Views749Altmetric-Citations110LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Conventional n-channel MOSFET devices using single layer HfO/sub 2/ and ZrO/sub 2/ as high-k gate dielectrics with polysilicon gate electrode (2002)

Conventional self-aligned MOSFET transistors with poly-silicon gate-electrode were successfully fabricated using Hf-oxide and Zr-oxide as high-k gate-dielectrics. The gate-stack consisting of poly-silicon on Hf-oxide exhibited promising transistor characteristics with a S/D RTA temperature of 1000/spl deg/C, demonstrating feasibility of integrating high-k gate-dielectrics into conventional CMOS process technology. Effects of S/D RTA temperatures on the HfO/sub 2//poly-Si transistor characteristics were discussed. A gate-dimension dependent bi-modal gate leakage current was observed from ZrO/sub 2//poly-Si transistors.
Sterols. II. Unsaturation at the C<sub>22</sub>-Position and the Behavior of C<sub>20</sub>-Isomeric Carbinols (1945)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSterols. II. Unsaturation at the C22-Position and the Behavior of C20-Isomeric CarbinolsPercy L. Julian, Wayne Cole, Edwin W. Meyer, and R. A. HernessCite this: J. Am. Chem. Soc. 1945, 67, 8, 1375–1381Publication Date (Print):August 1, 1945Publication History Published online1 May 2002Published inissue 1 August 1945https://pubs.acs.org/doi/10.1021/ja01224a045https://doi.org/10.1021/ja01224a045research-articleACS PublicationsRequest reuse permissionsArticle Views63Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
640×480 back-illuminated CCD imager with improved blooming control for night vision (2002)

We describe a back-illuminated 640/spl times/480 CCD imager which operates at 30-Hz frame rates with 5 e/sup -/ noise and which is capable of high resolution down to near starlight illumination levels. A new process for fabricating a compact blooming control is also described.
Cessation of rapid late endosomal tubulovesicular trafficking in Niemann–Pick type C1 disease (2001)

Niemann-Pick type C1 (NPC1) disease results from a defect in the NPC1 protein and is characterized by a pathological accumulation of cholesterol and glycolipids in endocytic organelles. We followed the biosynthesis and trafficking of NPC1 with the use of a functional green fluorescent protein-fused NPC1. Newly synthesized NPC1 is exported from the endoplasmic reticulum and requires transit through the Golgi before it is targeted to late endosomes. NPC1-containing late endosomes then move by a dynamic process involving tubulation and fission, followed by rapid retrograde and anterograde migration along microtubules. Cell fusion studies with normal and mutant NPC1 cells show that exchange of contents between late endosomes and lysosomes depends upon ongoing tubulovesicular late endocytic trafficking. In turn, rapid endosomal tubular movement requires an intact NPC1 sterol-sensing domain and is retarded by an elevated endosomal cholesterol content. We conclude that the neuropathology and cellular lysosomal lipid accumulation in NPC1 disease results, at least in part, from striking defects in late endosomal tubulovesicular trafficking.
Low-Temperature High-Density Chip-Stack Interconnection Using Compliant Bump (2007)

We demonstrate low-temperature high-density chip-stack interconnection using compliant bump. Low temperature chip stacking was carried out by two methods; (1) plasma cleaning of compliant bumps, (2) mechanical caulking using compliant bump and doughnut-shaped electrode. The latter method is very effective in realizing chip stacking even at room temperature.
Second Order Hyperpolarizabilities of Barbituric Acid Derivatives (1989)

Abstract Barbituric acid derivatives with electron donors at 5-position were synthesized and their second order nonlinear optical properties were investigated by electric field induced second harmonic generation (EFISH) method. It was found that barbituric acid units were strong acceptors and contributed to the large second order hyperpolarizabilities.