gebhart/patrepeval huggingface dataset:
Amelioration of Sensory Nerve Dysfunction by C-Peptide in Patients With Type 1 Diabetes (2003)

Studies have demonstrated that proinsulin C-peptide stimulates the activities of Na(+),K(+)-ATPase and endothelial nitric oxide synthase, both of which are enzyme systems of importance for nerve function and known to be deficient in type 1 diabetes. The aim of this randomized double-blind placebo-controlled study was to investigate whether C-peptide replacement improves nerve function in patients with type 1 diabetes. Forty-nine patients without symptoms of peripheral neuropathy were randomized to either 3 months of treatment with C-peptide (600 nmol/24 h, four doses s.c.) or placebo. Forty-six patients (15 women and 31 men, aged 29 years, diabetes duration 10 years, and HbA(1c) 7.0%) completed the study. Neurological and neurophysiological measurements were performed before and after 6 and 12 weeks of treatment. At baseline the patients showed reduced nerve conduction velocities in the sural nerve (sensory nerve conduction velocity [SCV]: 50.9 +/- 0.70 vs. 54.2 +/- 1.2 m/s, P < 0.05) and peroneal nerve (motor nerve conduction velocity: 45.7 +/- 0.55 vs. 53.5 +/- 1.1 m/s, P < 0.001) compared with age-, height-, and sex-matched control subjects. In the C-peptide treated group there was a significant improvement in SCV amounting to 2.7 +/- 0.85 m/s (P < 0.05 compared with placebo) after 3 months of treatment, representing 80% correction of the initial reduction in SCV. The change in SCV was accompanied by an improvement in vibration perception in the patients receiving C-peptide (P < 0.05 compared with placebo), whereas no significant change was detectable in cold or heat perception. In conclusion, C-peptide administered for 3 months as replacement therapy to patients with early signs of diabetic neuropathy ameliorates nerve dysfunction.
The Photobromination of Tetrachloroethylene and of Chloroform with Special Reference to the Effects of Oxygen (1935)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Photobromination of Tetrachloroethylene and of Chloroform with Special Reference to the Effects of OxygenJohn Willard and Farrington DanielsCite this: J. Am. Chem. Soc. 1935, 57, 11, 2240–2245Publication Date (Print):November 1, 1935Publication History Published online1 May 2002Published inissue 1 November 1935https://pubs.acs.org/doi/10.1021/ja01314a060https://doi.org/10.1021/ja01314a060research-articleACS PublicationsRequest reuse permissionsArticle Views48Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Criteria for Evolution of Successful Proteins: Fold Fitness and Domain Dynamics Explored (2014)

The Haloacid Dehalogenase Superfamily (HADSF) is a ubiquitous family of enzyme with more than 32,000 members. A variety of reactions are catalyzed by HAD members, but a majority of HAD members are phosphatases. Dephosphorlyation of organophosphate metabolites are carried out in the conserved Rossmann-like core domain. The Rossman-like core domain houses the conserved active site residues necessary for catalysis and also supports domain inserts associated with substrate binding. This dissertation will focus primarily on investigating fold fitness and domain dynamics of HAD proteins more specifically three C2 capped proteins. The first part will focus on whether or not the prevailing tenet that “Catalytic Function Comes at the Expense of Protein Fold Stability” is applicable to the HADSF phosphatase. To test function at the cost of stability site directed mutagenesis was used to replace catalytic residues and used an array of techniques (CD/Fluorescence/SAXS) to monitored denaturation to evaluate stability in the resulting mutants. From denature results we conclude that although most catalytic residues play no role in stability, good or bad, one in particular Asp2 of DXD squiggle shows to be necessary for not only activity but stability as well. To identify what about the residue is essential to stability the side chain and interacting residues were examined. The Rossmann-like catalytic core domain is a robust domain, and to test the co-evolution of the cap and catalytic domains as a “coupled folding and catalytic units” will be examined. The structural co-dependency was tested by creating truncations of the catalytic and cap domains and identifying stability and activity of each domain and chimeric C2 capped proteins. Thermal denature of truncations and chimeric proteins reveal stability of each domain separately while the chimeric stability establish a robust core Rossmann-like catalytic domain. As previously discussed the cap domain increases function by increasing recognition of substrates. To examine the cap domains role in substrate-induced-fit we examined changes in protein solution conformation using small angle X-ray scattering (SAXS). Because HAD proteins have evolved separate domains for catalysis and recognition SAXS will also be used to investigate changes in conformation change due to changes in domain-domain interfacing residues. Solution scattering of Bt4131 help demonstrate an induced-fit mechanism for HAD proteins. In the presence of VO3 (phosphate analog) we see closure of cap domain whereas sugar moiety does not initiate closure of domain.
Perfil de saúde e qualidade de vida de idosos de Santa Juliana-MG (2014)

Resumo: Estudo quantitativo que analisou o perfil de saúde e qualidade de vida da população idosa do município de Santa Juliana-MG. Entre os207 idosos, 53,6% eram mulheres, com idade média de 70±7,5 anos. 56% vivem com companheiro e 78,7% são aposentados. A Hipertensão Arterial,a cardiopatia e doenças reumáticas foram as mais relatadas e com relação à qualidade de vida, o domínio meio ambiente era o mais prejudicado. Apesquisa aponta a necessidade de ações de promoção e educação em saúde tendo como foco o autocuidado, a prevenção de agravos e incorporandoestratégias de atenção social ao idoso.Descritores: Perfil de saúde, Idoso, Qualidade de vida.Health profile and quality of life of the elderly in Santa Juliana (MG)Abstract: Quantitative study that examined the health profile and quality of life of the elderly population of the municipality of Santa Juliana-MG.Among the 207 individuals, 53.6% were women, aged about 70 ± 7.5 years. 56% live with companion and 78.7% are retired. High blood pressure, heartdisease and rheumatic diseases were the most reported and with regard to the quality of life, the environment was the most affected. This research pointsthe need for promotional and health education focusing the self-care, prevention of diseases and social attention strategies incorporating the elderly.Descriptors: Health profile; Aged; Quality of life.Perfil de salud y calidad de vida de los ancianos de Santa Juliana (MG)Resumen: Estudio cuantitativo que examina el perfil de salud y la calidad de vida de la población anciana del municipio de Santa Juliana-MG. Entre los207 individuos, 53,6% eran mujeres, con edad media de 70 ± 7,5 años. 56% vive con acompañante y 78.7% son aposentados. La presión arterial alta,enfermedades del corazón y enfermedades reumáticas fueron las más reportadas y con respecto a la calidad de vida, el medio ambiente fue el dominiomás afectado. Esa investigación apunta la necesidad de promoción y educación para la salud centrándose en autocuidado, prevención de enfermedadesy estrategias de atención social incorporando los ancianos.Descriptores: Perfil de salud; Anciano; Calidad de vida.
Development of a Climbing Robot for Inspection of Bridge Cable (2012)

In this paper, we propose a cable climbing robot which can climb up and down the cables in the bridges. The robot mechanism consists of three parts: a wheel based driving mechanism, adhesion mechanism, and safe landing mechanism. The wheel based driving mechanism is driven by tooth clutches and motors. The adhesion mechanism plays the role of maintaining adhesion force by a combination of pantograph, ball screw, and springs even when the power is lost. The safe landing mechanism is developed for guaranteeing the safety of the robot during operations on cables. It can make the robot fall down with reduced speed by dissipating the gravitational forces. The robot mechanism is designed and manufactured for validating its effectiveness.
Ion-size effect on superconducting transition temperature<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi>T</mml:mi></mml:mrow><mml:mrow><mml:mi>c</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math>in<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi>R</mml:mi></mml:mrow><mml:mrow><mml:mn>1</mml:mn><mml:mi>−</mml:mi><mml:mi>x</mml:mi><mml:mi>−</mml:mi><mml:mi>y</mml:mi></mml:mrow></mml:msub></mml:mrow><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">Pr</mml:mi></mml:mrow><mml:mrow><mml:mi>x</mml:mi></mml:mrow></mml:msub></mml:mrow><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">Ca</mml:mi></mml:mrow><mml:mrow><mml:mi>y</mml:mi></mml:mrow></mml:msub></mml:mrow><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">Ba</mml:mi></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msub></mml:mrow><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">Cu</mml:mi></mml:mrow><mml:mrow><mml:mn>3</mml:mn></mml:mrow></mml:msub></mml:mrow><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">O</mml:mi></mml:mrow><mml:mrow><mml:mn>7</mml:mn><mml:mi>−</mml:mi><mml:mi>z</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math>systems (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mi>R</mml:mi><mml:mo>=</mml:mo><mml:mi mathvariant="normal">Er</mml:mi><mml:mo>,</mml:mo></mml:math>Dy, Gd, Eu, Sm, and Nd) (1999)

We observed a rare-earth ion-size effect on ${T}_{c}$ in ${R}_{1\ensuremath{-}x\ensuremath{-}y}{\mathrm{Pr}}_{x}{\mathrm{Ca}}_{y}{\mathrm{Ba}}_{2}{\mathrm{Cu}}_{3}{\mathrm{O}}_{7\ensuremath{-}z}$ ($R=\mathrm{Er},$ Dy, Gd, Eu, Sm, and Nd) systems which is similar to that in ${R}_{1\ensuremath{-}x}{\mathrm{Pr}}_{x}{\mathrm{Ba}}_{2}{\mathrm{Cu}}_{3}{\mathrm{O}}_{7\ensuremath{-}z}$ systems in our previous reports. For fixed Pr and Ca concentration (fixed x and y), ${T}_{c}$ is linearly dependent on rare-earth ion radius ${r}_{R}^{3+}.$ For a fixed Pr concentration x, there exists a maximum of ${T}_{c}$ ${(T}_{c,\mathrm{max}})$ in ${T}_{c}$ vs Ca concentration y curves. ${T}_{c,\mathrm{max}}$ shifts to higher Ca concentration region for samples with larger R ion radius. The enhancement of ${T}_{c}$ ($\ensuremath{\Delta}{T}_{c,\mathrm{max}}{=T}_{c,\mathrm{max}}\ensuremath{-}{T}_{c,y=0};$ ${T}_{c,y=0}$ is the transition temperature ${T}_{c}$ without Ca doping) increases with increasing R ion radius. We proposed an empirical formula for ${T}_{c}$ ${(r}_{R}^{3+},x,y)$ to fit our experimental data: ${T}_{c}{(x,y)=T}_{c0}\ensuremath{-}A{\ensuremath{\beta}}^{2}(\ensuremath{\alpha}/x+y/\ensuremath{\beta}{)}^{2}\ensuremath{-}\mathrm{Bx}.$ All fitting parameters in this formula, ${T}_{c0},$ B, \ensuremath{\beta}, \ensuremath{\alpha}/\ensuremath{\beta}, and $A{\ensuremath{\beta}}^{2},$ are rare-earth ion-size dependent.
Spectrophotometric Determination of Iron(III) Based on Its Catalytic Effect on the Oxidation of Diphenylamine with Hydrogen Peroxide in the Presence of Cetylpyridinium Chloride (2006)

A new catalytic kinetic method for the determination of trace iron(III) over the concentration range 1 -100 ng ml -1 is described. The detection limit was 0.52 ng ml -1 . The sensitivity of the determination was increased in the presence of cetylpyridinium chloride (CPC). The reaction rate was monitored spectrophotometrically by measuring the absorbance of the reaction product at 580 nm. The variables that affected the reaction rate were investigated and the reaction conditions were established.
Clinical Applications and Biosafety of Human Adult Mesenchymal Stem Cells (2012)

Mesenchymal Stem Cells (MSCs) are a population of adherent cells that can differentiate into mesenchymal lineage populations (cartilage, bone and fat tissue). In addition, they seem to be able to differentiate also into a broader type of lineages other than the original mesodermal germ layer. Bone marrow MSCs are a standard in the field of adult stem cell biology and clinical applications; however adipose-derived MSCs are becoming an attractive alternative due to their minimally invasive accessibility and availability in the body. MSCs modulate several effector immune functions by interacting both with innate and adoptive immune responses. Several local signals from the tissue microenvironment, together with cytokine and soluble factors released by MSCs influence anti-inflammatory and tissue repair properties of infused MSCs. Therefore, cellular therapies utilizing ex vivo expanded MSCs may be an interesting approach for inflammatory and autoimmune diseases. Biosafety is still one of the most important aspects; therefore the production of clinical-grade MSCs requires the careful identification and control of all the phases of cell manipulation and release. Many clinical applications of adult MSCs are in progress and are using bone marrow or adipose tissue-derived MSCs for the treatment of Graft Versus Host Disease (GVHD), inflammatory joint diseases and osteocartilagineous defects, digestive tract, cardiovascular and neurological diseases.
Hierarchical Clustering Analysis With Som Networks (2010)

This work presents a neural network model for the clustering analysis of data based on Self Organizing Maps (SOM). The model evolves during the training stage towards a hierarchical structure according to the input requirements. The hierarchical structure symbolizes a specialization tool that provides refinements of the classification process. The structure behaves like a single map with different resolutions depending on the region to analyze. The benefits and performance of the algorithm are discussed in application to the Iris dataset, a classical example for pattern recognition.
SounDroid: Supporting Real-Time Sound Applications on Commodity Mobile Devices (2015)

A variety of advantages from sounds such as measurement and accessibility introduces a new opportunity for mobile applications to offer broad types of interesting, valuable functionalities, supporting a richer user experience. However, in spite of the growing interests on mobile sound applications, few or no works have been done in focusing on managing an audio device effectively. More specifically, their low level of real-time capability for audio resources makes it challenging to satisfy tight timing requirements of mobile sound applications, e.g., a high sensing rate of acoustic sensing applications. To address this problem, this work presents the SounDroid framework, an audio device management framework for real-time audio requests from mobile sound applications. The design of SounDroid is based on the requirement analysis of audio requests as well as an understanding of the audio playback procedure including the audio request scheduling and dispatching on Android. It then incorporates both real-time audio request scheduling algorithms, called EDF-V and AFDS, and dispatching optimization techniques into mobile platforms, and thus improves the quality-of-service of mobile sound applications. Our experimental results with the prototype implementation of SounDroid demonstrate that it is able to enhance scheduling performance for audio requests, compared to traditional mechanisms (by up to 40% of improvement), while allowing deterministic dispatching latency.
Disaster avoidance control against heavy rainfall (2017)

This paper proposes a disaster avoidance control method for use against heavy rainfall and discusses its effectiveness through actual weather data. The proposed control method uses geographical information data including weather data, hazard area data, and physical network data. By applying technologies related to meteorology, erosion control, and civil engineering to such data, the proposed method can evaluate the risk of a physical network being disconnected. On the basis of the evaluated risk, the proposed method reconfigures a logical network to reduce service disruption. The proposed method is applied to a cloud computing service network where, in addition to route changes, the relocation of virtual machines is possible, increasing its effectiveness. By using empirical data, we show that the proposed method reduces the probability of service disconnection to almost zero even for heavy rainfall causing landslides. Finally, an experimental system of the proposed method was implemented through software defined network technology and successfully controlled the experimental network.
Skill Acquisition in Skin Cancer Detection (2010)

Previous research has shown that the ability to detect potentially dangerous skin lesions is not improved by viewing a pamphlet describing the characteristic features of such lesions. A different approach to improving this skill was investigated in this study. 100 student recruits were tested to investigate the effect of practice at distinguishing between dangerous and nondangerous skin lesions. Around 30 minutes of such practice, viewing 360 pictures of skin lesions, provided a significant advantage in making decisions about a target set of dangerous and nondangerous lesions, compared to no practice or practice with a filler task. Viewing a skin cancer pamphlet for 5 min. at the beginning of the experiment made no difference to the speed or accuracy of decisions regarding the test lesions. The results are interpreted as evidence for a form of implicit learning of a skin cancer detection skill, a finding that is consistent with what is known of the nature of expertise in dermatologists. The results also point to the ineffectiveness of pamphlets to engender such expertise in the general public.
Isolation and Characterization of Thaxtomin-Type Phytotoxins Associated with Streptomyces ipomoeae (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIsolation and Characterization of Thaxtomin-Type Phytotoxins Associated with Streptomyces ipomoeaeRussell R. King, C. Harold Lawrence, Larry A. Calhoun, and Jean B. RistainoCite this: J. Agric. Food Chem. 1994, 42, 8, 1791–1794Publication Date (Print):August 1, 1994Publication History Published online1 May 2002Published inissue 1 August 1994https://pubs.acs.org/doi/10.1021/jf00044a042https://doi.org/10.1021/jf00044a042research-articleACS PublicationsRequest reuse permissionsArticle Views293Altmetric-Citations39LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Developmental validation of the GlobalFiler® express kit, a 24-marker STR assay, on the RapidHIT® System (2014)

Rapid DNA typing provides a transformative solution to help forensic laboratories and law enforcement agencies solve and prevent crimes. The RapidHIT(®) System is a fully integrated instrument with a simplified user interface enabling an operator to run the system and obtain a DNA profile from a sample in less than two hours. The integration and developmental validation of the NDIS-approved 24 loci GlobalFiler(®) Express kit expands the capabilities of the RapidHIT System to increase discrimination power, reduce adventitious matches, and improve cross-border data sharing capabilities. Developmental validation studies were performed according to the SWGDAM guidelines and tested several critical areas of performance including three sensitivity studies, inhibited samples, thermal cycling parameters, and cross-contamination. Validation studies indicate that the optimized PCR parameters and sensitivity of the system is capable of generating STR profiles from buccal or blood swab reference samples. Results were concordant with genotypes produced using standard bench thermal cyclers and capillary electrophoresis platforms. Furthermore, swabs can be retrieved from the system and re-run or reprocessed with traditional bench chemistries, e.g. Y-STRs, to gain additional information. Our results demonstrate that the GlobalFiler Express assay run on the RapidHIT System is reliable for generating profiles from reference samples after forensic review.
Decreased expression of the ligand for CD40 in newborn lymphocytes (1994)

Immune responses in newborn lymphocytes show a defect in isotype switching from IgM to IgG and IgA. Immunoglobulin isotype switching in B lymphocytes requires a contact-dependent signal from T lymphocytes which is delivered by the ligand for the B cell surface antigen CD40. We investigated the capacity of newborn lymphocytes to express the CD40 ligand and to undergo CD40 ligand-dependent immunoglobulin isotype switching. After stimulation by phorbol ester and ionomycin, newborn lymphocytes expressed markedly decreased amounts of CD40 ligand on their surface compared to normal adult lymphocytes. Northern blot analysis of mRNA derived from activated cord blood lymphocytes also revealed markedly decreased amounts of CD40 ligand mRNA. Decreased expression of CD40 ligand in newborn lymphocytes was associated with a severely decreased ability to undergo T cell-dependent immunoglobulin isotype switching. Newborn lymphocytes synthesized little or no detectable IgE in response to T cell-dependent stimulation by interleukin-4 but synthesized IgE in response to T cell-independent stimulation by CD40 monoclonal antibody and interleukin-4. These results indicate that decreased expression of CD40 ligand in newborn lymphocytes may be the underlying cause of deficient immunoglobulin isotype switching in newborns.
ChemInform Abstract: Regiospecific Cyclization of β‐Methoxyvinyl Trifluoromethyl Ketones with Aminoguanidine: A Convenient Method to Obtain Trifluoromethylated 2‐[1H‐Pyrazol‐1‐yl]pyrimidines. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.