gebhart/patrepeval huggingface dataset:
Optimizing IBM algorithmics' mark-to-future aggregation engine for real-time counterparty credit risk scoring (2013)

The concept of default and its associated painful repercussions have been a particular area of focus for financial institutions, especially after the 2007/2008 global financial crisis. Counterparty credit risk (CCR), i.e. risk associated with a counterparty default prior to the expiration of a contract, has gained tremendous amount of attention which resulted in new CCR measures and regulations being introduced. In particular users would like to measure the potential impact of each real time trade or potential real time trade against exposure limits for the counterparty using Monte Carlo simulations of the trade value, and also calculate the Credit Value Adjustment (i.e, how much it will cost to cover the risk of default with this particular counterparty if/when the trade is made). These rapid limit checks and CVA calculations demand more compute power from the hardware. Furthermore, with the emergence of electronic trading, the extreme low latency and high throughput real time compute requirement push both the software and hardware capabilities to the limit. Our work focuses on optimizing the computation of risk measures and trade processing in the existing Mark-to-future Aggregation (MAG) engine in the IBM Algorithmics product offering. We propose a new software approach to speed up the end-to-end trade processing based on a pre-compiled approach. The net result is an impressive speed up of 3--5x over the existing MAG engine using a real client workload, for processing trades which perform limit check and CVA reporting on exposures while taking full collateral modelling into account.
Comparative sequence analysis of a genus-common rickettsial antigen gene (1989)

The genes encoding the 17-kilodalton genus-common antigen have been cloned and sequenced from Rickettsia conorii, Rickettsia prowazekii, and Rickettsia typhi. Compared with the R. rickettsii sequence, this sequence had a high degree of homology within the coding and control regions (R. conorii, 99.8%; R. prowazekii, 88.1%; R. typhi, 88.7%). The 5' flanking regions, including the promoter and the transcription initiation sites, were extremely well conserved for all four species, suggesting that control and expression of this locus are important to the survival of the rickettsiae.
Nonlinear Optics at Low Light Levels (1999)

We show how the combination of electromagnetically induced transparency based nonlinear optics and cold atom technology, under conditions of ultraslow light propagation, allows nonlinear processes at energies of a few photons per atomic cross section.
Lasing at the band edges of plasmonic lattices (2014)

This paper reports a comprehensive experimental study of silver and gold plasmonic crystal lasers. Such periodic plasmon particle systems have recently triggered large attention due to the fact that localized plasmons and collective lattice resonances conspire to give large light-matter interaction strength in narrow resonances. The authors provide a detailed report on the conditions required for lasing, and a complete analysis of the underlying plasmonic lattice band structure.
Reduction of platelet phospholipase C activity in patients with Alzheimer disease. (1995)

Phosphoinositide-specific phospholipase C (PLC) is a key enzyme in signal transduction. We have previously demonstrated that a PLC isozyme is abnormally accumulated in the brain tissue in Alzheimer's disease (AD). AD has been suggested to be a systemic disease in which the expression of abnormalities is most prominent in neuronal tissues. In a recent study, we have revealed the increase of the cytosolic protein kinase C (PKC) concentration in platelets of AD patients, suggesting the change of PLC, which is upstream to PKC in phosphoinositide metabolism. In this study, we examined phosphatidylinositol-specific PLC activity in platelets from patients with AD and age-matched controls by measuring the formation of radioactive inositol phosphate. The PLC activity was significantly lower in the AD platelets than in the controls. These findings suggest that aberrant phosphoinositide metabolism is present in nonneuronal tissues as well as the brain in AD.
Comparative behaviour of the Dynamically Penalized Likelihood algorithm in inverse radiation therapy planning (2001)

This paper presents a description of tests carried out to compare the behaviour of five algorithms in inverse radiation therapy planning: (1) The Dynamically Penalized Likelihood (DPL), an algorithm based on statistical estimation theory; (2) an accelerated version of the same algorithm: (3) a new fast adaptive simulated annealing (ASA) algorithm; (4) a conjugate gradient method; and (5) a Newton gradient method. A three-dimensional mathematical phantom and two clinical cases have been studied in detail. The phantom consisted of a U-shaped tumour with a partially enclosed 'spinal cord'. The clinical examples were a cavernous sinus meningioma and a prostate case. The algorithms have been tested in carefully selected and controlled conditions so as to ensure fairness in the assessment of results. It has been found that all five methods can yield relatively similar optimizations, except when a very demanding optimization is carried out. For the easier cases. the differences are principally in robustness, ease of use and optimization speed. In the more demanding case, there are significant differences in the resulting dose distributions. The accelerated DPL emerges as possibly the algorithm of choice for clinical practice. An appendix describes the differences in behaviour between the new ASA method and the one based on a patent by the Nomos Corporation.
Gender-Specific Differences in the Perceived Antecedents of Academic Stress (1993)

This study was undertaken to establish the existence of any gender-specific differences in the perceived antecedents of academic stress. The Academic Pressure Scale for Adolescents was administered to 112 girls and 160 boys attending high school. Significant gender-based differences were obtained on eight of the 35 questions of the scale. In each case girls reported greater stress than boys. This study provides strong evidence that girls and boys of high school age differentially experience the antecedents of academic stress and that adolescent girls experience greater academic stress than boys.
Role of adipose tissue in body-weight regulation: mechanisms regulating leptin production and energy balance (2000)

Adipose tissue performs complex metabolic and endocrine functions. Among the endocrine products produced by adipose tissue are tumour necrosis factor alpha, interleukin 6, acylation-stimulating protein and leptin. The present review will focus primarily on mechanisms regulating leptin production and leptin action, and the implications of this regulation in the control of energy balance. Leptin acts in the central nervous system where it interacts with a number of hypothalamic neuropeptide systems to regulate feeding behaviour and energy expenditure. The presence of extreme obesity in animals and human subjects with mutations of the leptin gene or the leptin receptor demonstrates that normal leptin production and action are critical for maintaining energy balance. Insulin is the major regulator of leptin production by adipose tissue. Insulin infusions increase circulating leptin concentrations in human subjects. Plasma leptin levels are markedly decreased in insulin-deficient diabetic rodents, and the low leptin levels contribute to diabetic hyperphagia. Based on in vitro studies, the effect of insulin to stimulate leptin production appears to involve increased glucose metabolism. Blockade of glucose transport or glycolysis inhibits leptin expression and secretion in isolated adipocytes. Evidence suggests that anaerobic metabolism of glucose to lactate does not stimulate leptin production. Alterations in insulin-mediated glucose metabolism in adipose tissue are likely to mediate the effects of energy restriction to decrease, and refeeding to increase, circulating leptin levels. Changes in glucose metabolism may also explain the observation that high-fat meals lower 24h circulating leptin levels relative to high-carbohydrate meals in human subjects, suggesting a mechanism that may contribute to the effects that high-fat diets have in promoting increased energy intake, weight gain and obesity. The decreased circulating leptin observed during energy restriction is related to increased sensations of hunger in human subjects. Thus, decreases in leptin during energy-restricted weight-loss regimens may contribute to the strong propensity for weight regain. A better understanding of the precise mechanisms regulating leptin production and leptin action may lead to new approaches for managing obesity.
Adenovirus-mediated gene delivery of tissue inhibitor of metalloproteinases-3 inhibits invasion and induces apoptosis in melanoma cells. (1998)

We have used adenovirus-mediated gene delivery of tissue inhibitor of metalloproteinase (TIMP)-1, -2, and -3 to examine their effect on the invasion capacity of metastatic melanoma cell lines SK-Mel-5 and A2058. Infection of melanoma cells with recombinant replication-deficient adenoviruses coding for TIMP-1, TIMP-2, and TIMP-3 resulted in marked secretion of TIMP-1 and TIMP-2 to culture medium and accumulation of TIMP-3 to matrix. Overexpression of TIMP-3 inhibited invasion of SK-Mel-5 and A2058 cells through reconstituted basement membrane (Matrigel) even more potently than TIMP-1 and TIMP-2. In addition, overproduction of TIMP-3 reduced attachment of melanoma cells to type I and IV collagen and fibronectin and resulted in apoptosis in both SK-Mel-5 and A2058 cells. These results propose a novel role for TIMP-3 in regulation of invasion and survival of malignant cells and suggest potential use for TIMP-3 in adenovirus-mediated gene therapy of malignant melanoma.
Position Sensing in Brake-By-Wire Callipers Using Resolvers (2006)

Recent designs for brake-by-wire systems use "resolvers" to provide accurate and continuous measurements for the absolute position and speed of the rotor of the electric actuators in brake callipers (permanent magnet DC motors). Resolvers are absolute-angle transducers that are integrated with estimator modules called "angle tracking observer" and together they provide position and speed measurements. Current designs for angle-tracking observers are unstable in applications with high acceleration and/or speed. In this paper, we introduce a new angle-tracking observer in which a closed-loop linear time-invariant (LTI) observer is integrated with a quadrature encoder. Finite-gain stability of the proposed design and its robustness to three different kinds of parameter variations are proven based on theorems of input-output stability in nonlinear control theory. In our experiments, we examined the performance of our observer and two other methods (a well-known LTI observer and an extended Kalman filter) to estimate the position and speed of a brake-by-wire actuator. The results show that because of the very high speed and acceleration of the actuator in this application, the LTI observer and Kalman filter cannot track the rotor position and diverge. In contrast, with a properly designed open-loop transfer function and selecting a suitable switching threshold, our proposed angle-tracking observer is stable and highly accurate in a brake-by-wire application
Enhancing Recovery after Stroke with Noradrenergic Pharmacotherapy: A New Frontier? (2000)

Despite much progress in stroke prevention and acute intervention, recovery and rehabilitation have traditionally received relatively little scientific attention. There is now increasing interest in the development of stroke recovery drugs and innovative rehabilitation techniques to promote functional recovery after completed stroke. Experimental work over the past two decades indicates that pharmacologic intervention to enhance recovery may be possible in the subacute stage, days to weeks poststroke, after irreversible injury has occurred. This paper discusses the concept of "rehabilitation pharmacology" and reviews the growing literature from animal studies and pilot clinical trials on noradrenergic pharmacotherapy, a new experimental strategy in stroke rehabilitation. Amphetamine, a monoamine agonist that increases brain norepinephrine levels, is the most extensively studied drug shown to promote recovery of function in animal models of focal brain injury. Further research is needed to investigate the mechanisms and clinical efficacy of amphetamine and other novel therapeutic interventions on the recovery process.
Foxo1 Links Hyperglycemia to LDL Oxidation and Endothelial Nitric Oxide Synthase Dysfunction in Vascular Endothelial Cells (2009)

The findings reveal a hitherto unsuspected role of the endothelial iNOS-NO-peroxynitrite pathway in lipid peroxidation and eNOS dysfunction and suggest that Foxo1 activation in response to hyperglycemia brings about proatherogenic changes in vascular endothelial cell function.
Cloning and Characterization of Human Tissue Inhibitor of Metalloproteinases-3 (1994)

The tissue inhibitors of metalloproteinases (TIMPs) comprise a family of proteins, of which two members have so far been described in humans. We have cloned and sequenced a third human TIMP (hTIMP-3) from phorbol ester-differentiated THP-1 cells stimulated with bacterial lipopolysaccharide. The open reading frame encodes a 211-amino-acid precursor including a 23-residue secretion signal. The mature polypeptide has a calculated molecular weight of 21.6 kD and includes an N-linked glycosylation site near the carboxyl terminus. The protein is quite basic, having a predicted isoelectric point of 9.04. We have mapped the single gene encoding human TIMP-3 to chromosome 22. By Northern analysis, transcripts for TIMP-3 were identified in a broad cross-section of tissues examined from both embryonic and adult origin. In all tissues except the placenta, the predominant transcript was 5.0 kb in size, with minor bands around 2.4 and 2.6 kb comprising no more than about 10% of the signal. In the placenta, the smaller bands accounted for close to 50% of the signal. Human TIMP-3 shows slightly closer amino acid sequence similarity to TIMP-2 (44.3%) than to TIMP-1 (38.4%), but is most closely related to a recently reported chicken TIMP, chIMP-3 (80.8% amino acid; 77.7% nucleic acid similarity.
Targeted Comparative Proteomics by Liquid Chromatography-Tandem Fourier Ion Cyclotron Resonance Mass Spectrometry (2004)

In proteomics, effective methods are needed for identifying the relatively limited subset of proteins displaying significant changes in abundance between two samples. One way to accomplish this task is to target for identification by MS/MS only the "interesting" proteins based on the abundance ratio of isotopically labeled pairs of peptides. We have developed the software and hardware tools for online LC-FTICR MS/MS studies in which a set of initially unidentified peptides from a proteome analysis can be selected for identification based on their distinctive changes in abundance following a "perturbation". We report here the validation of this method using a mixture of standard proteins combined in different ratios after isotopic labeling. We also demonstrate the application of this method to the identification of Shewanella oneidensis peptides/proteins exhibiting differential abundance in suboxic versus aerobic cell cultures.
Sub-10-nm-wide intercalated multi-layer graphene interconnects with low resistivity (2014)

We fabricated sub-10-nm-wide intercalated multi-layer graphene (MLG) interconnects and demonstrated a resistivity lower than that of cupper (Cu) interconnects with similar dimensions. The high-quality MLG was synthesized epitaxially by chemical vapor deposition on an epitaxial cobalt film, and intercalated with FeCl <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> . After narrowing down the width to 8 nm by electron beam lithography, the 8-nm-wide intercalated MLG exhibited a resistivity of 3.2 µΩcm, which is predicted to be lower than that of Cu interconnects with the same dimensions. Our results show that intercalated MLG is really promising for future LSI interconnects.
Low-temperature, palladium(II)-catalyzed, solution-phase oxidation of methane to methanol derivative (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLow-temperature, palladium(II)-catalyzed, solution-phase oxidation of methane to methanol derivativeLien Chung Kao, Alan C. Hutson, and Ayusman SenCite this: J. Am. Chem. Soc. 1991, 113, 2, 700–701Publication Date (Print):January 1, 1991Publication History Published online1 May 2002Published inissue 1 January 1991https://pubs.acs.org/doi/10.1021/ja00002a063https://doi.org/10.1021/ja00002a063research-articleACS PublicationsRequest reuse permissionsArticle Views1434Altmetric-Citations195LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Human marrow cells-derived cultured bone in porous ceramics. (1998)

From four patients (mean age, 60 years; range 51-76 years), 3 ml of bone marrow was collected from the ilium. The marrow was cultured to concentrate and expand the marrow mesenchymal cells on a culture dish. The cultured cells were then subcultured either on another culture dish or in porous areas of hydroxyapatite ceramics in the presence of dexamethasone and beta-glycerophosphate (osteogenic medium). The subcultured tissues on the dishes were analyzed by scanning electron microscopy (SEM), and subcultured tissues in the ceramics were implanted intraperitoneally into athymic nude mice. Vigorous growth of spindle-shaped cells and a marked formation of bone matrix beneath the cell layers was observed on the subculture dishes by SEM. The intraperitoneally implanted ceramics with cultured tissues revealed thick layer of lamellar bone together with active osteoblasts lining in many pore areas of the ceramics after 2 months. The in vitro bone formation on the culture dishes and in vivo bone formation in porous ceramics were detected in all cases. These results indicate that we can assemble an in vitro bone/ceramic construct, and due to the porous framework of the ceramic, the construct has osteogenic potential similar to that of autologous cancellous bone. A significant benefit of this method is that the construct can be made with only a small amount of aspirated marrow cells from aged patients with little host morbidity.
EGFR-targeted treatment in non-small-cell lung cancer (2008)

Epidermal growth factor receptor (EGFR) is necessary in normal epithelial cell growth. Ab-errant EGFR expression is linked with increased cell proliferation and decreased apoptosis. Mutations and over-expression of EGFR are common features of many cancers. Therefore, Therapeutic agents that target the EGFR signal pathway, such as small-molecule tyrosine kinase inhibiiors and monoclonal antibodies are now advanced in clinical development. EGFR-targeted therapies of non-small-cell lung cancer (NSCLC) have been studied as a new way.

Key words: 
Receptor,epidermal growth factor;  Carcinoma, non-small-cell lung
IEEE Std 802.15.4 Technical Overview (2011)

<P>This chapter contains sections titled:<UL><LI><P>How Low-Cost and Long Battery Life Are Achieved</P></LI><LI><P>Other Notable IEEE Std 802.15.4 Features</P></LI><LI><P>Four Frame Types</P></LI></UL></P>
A 43-45Gb/s 2.5V integrated clock and data recovery circuit in sige using low-voltage topologies (2005)

A 43-45Gb/s clock and data recovery circuit is presented. It uses half-rate architecture with a binary phase detector based on low-voltage latch and multiplexer topologies. The circuit was implemented in a SiGe technology with f/sub T/ = 120GHz. It demonstrates a 600 MHz locking range and consumes 650mW from a 2.5V power supply. The chip measures 1.25mm/sup 2/ and requires no external components.
Immunocytochemical localization of arachidonate 15-lipoxygenase in erythrocytes, leukocytes, and airway cells. (1991)

In reticulocytes, the enzyme 15-lipoxygenase (15-LO) is believed to contribute to cellular differentiation, and in leukocytes and airway cells 15-LO generates inflammatory mediators. The recent availability of antibodies to 15-LO now allows us to determine which specific cells contain the enzyme, to characterize its subcellular localization, and to determine its expression at the translational level. A polyclonal antibody to recombinant human reticulocyte 15-LO was used with a standard immunofluorescent technique. In rabbit red blood cells, fluorescence appeared during the course of anemia. Early reticulocytes did not fluoresce, but more mature reticulocytes showed increased fluorescent intensity. Late reticulocytes contained little fluorescence. Among human leukocytes, only eosinophils fluoresced. In human trachea, 15-LO immunofluorescence was localized to epithelial cells, and both basal and ciliated cells fluoresced. In all cells studied, fluorescence was localized to the cytoplasm and was variable in degree among cells in each preparation. We conclude that the 15-LO of airway cells and eosinophils is immunologically related to the reticulocyte 15-LO. Furthermore, the variable fluorescence among cells (e.g., in epithelium) and during development (e.g., reticulocytes) suggests a role of 15-LO in cell growth and development.
Reconstructing the internal world of the eating-disordered individual: Overcoming denial and distortion in self-report (1991)

Although denial and distortion are widely acknowledged to affect the accuracy of self-report in the eating disorders, little is known about their extent and implications, and there have been few attempts to develop systematic strategies for obtaining more valid data. In anorexia nervosa and bulimia nervosa, internal experience may be misrepresented through the processes of deliberate distortion, inadvertent distortion, or overcompliance. Traditional methods of overcoming or correcting for denial include clinical intuition, reliance on the testimony of treated patients, and direct confrontation. Unfortunately, each of these approaches may compound subjects' biases with clinician—researchers' biases. Alternative methods for reducing denial and distortion in self-report must be developed; these may include separating research and therapy, providing incentives for accurate accounts, obtaining information from other informants, using more appropriate control groups, collecting data in vivo, asking for behavioral commitments, seeking subjects' commentary on their own responses, and making more creative use of nonobvious assessment techniques.