gebhart/patrepeval huggingface dataset:
Sexual Dysfunction Associated With Thioridazine Hydrochloride (1964)

A DECADE OF psychiatric treatment has been marked by the advent and increased usage of numerous psychopharmacological agents. Throughout this period the search has continued to aid in the development of effective agents which have minimal side effects. Thioridazine hydrochoride (Mellaril) has received wide acceptance as an effective phenothiazine with a relatively low incidence of side effects.<sup>1</sup>However, there have been sporadic reports<sup>2-6</sup>during the past three years of an unusual side effect occurring in male patients taking thioridazine hydrochloride. The capacity for sexual excitation, with concomitant erection and orgasm, was intact, but without apparent evidence of ejaculation and emission of semen. This side effect has not been reported in normal subjects, and it was not observed in the author's experience with six normal males taking thioridazine hydrochloride.<sup>7</sup>(This is not a statistically significant absence.) It has not been reported for other phenothiazines, but it has been
Mechanistic studies on the dextransucrase of streptococcus sanguis ATCC 10558 : [Alpha]-1-fluroglucose as a substrate for the enzyme / (1978)

The following explanation of techniques is provided to help you understand markings or patterns which may appear on this reproduction.1.The sign or "target" for pages apparently lacking from the document photographed is "Missing Page(s)".If it was possible to obtain the missing page(s) or section, they are spliced into the film along with adjacent pages.This may have necessitated cutting thru an image and duplicating adjacent pages to insure you complete continuity.2. When an image on the film is obliterated with a large round black mark, it is an indication that the photographer suspected that the copy may have moved during exposure and thus cause a blurred image.You will find a good image of the page in the adjacent frame.3. When a map, drawing or chart, etc., was part of the material being photographed the photographer followed a definite method in "sectioning" the material.It is customary to begin photoing at the upper left hand corner of a large sheet and to continue photoing from left to right in equal sections with a small overlap.If necessary, sectioning is continued again -beginning below the first row and continuing on until complete.4. The majority of users indicate that the textual content is of greatest value, however, a somewhat higher quality reproduction could be made from "photographs" if essential to the understanding of the dissertation.
Synthetic pyrethroids ? a new class of insecticide (1978)

M. Elliott and N. F. Janes, Chem. Soc. Rev., 1978, 7, 473 DOI: 10.1039/CS9780700473
Concise Synthesis of Mappicine Ketone and (±)-Mappicine (1996)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTConcise Synthesis of Mappicine Ketone and (±)-MappicineDaniel L. Comins and Jayanta K. SahaView Author Information Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695-8204 Cite this: J. Org. Chem. 1996, 61, 26, 9623–9624Publication Date (Web):December 27, 1996Publication History Received4 September 1996Published online27 December 1996Published inissue 1 January 1996https://pubs.acs.org/doi/10.1021/jo961698vhttps://doi.org/10.1021/jo961698vbrief-reportACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views478Altmetric-Citations61LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Chemical synthesis,Ketones,Organic synthesis Get e-Alerts
BACTERIAL HEAVY METAL RESISTANCE: New Surprises (1996)

Bacterial plasmids encode resistance systems for toxic metal ions including Ag+, AsO2-, AsO4(3-), Cd2+, CO2+, CrO4(2-), Cu2+, Hg2+, Ni2+, Pb2+, Sb3+, TeO3(2-), Tl+, and Zn2+. In addition to understanding of the molecular genetics and environmental roles of these resistances, studies during the last few years have provided surprises and new biochemical mechanisms. Chromosomal determinants of toxic metal resistances are known, and the distinction between plasmid resistances and those from chromosomal genes has blurred, because for some metals (notably mercury and arsenic), the plasmid and chromosomal determinants are basically the same. Other systems, such as copper transport ATPases and metallothionein cation-binding proteins, are only known from chromosomal genes. The largest group of metal resistance systems function by energy-dependent efflux of toxic ions. Some of the efflux systems are ATPases and others are chemiosmotic cation/proton antiporters. The CadA cadmium resistance ATPase of gram-positive bacteria and the CopB copper efflux system of Enterococcus hirae are homologous to P-type ATPases of animals and plants. The CadA ATPase protein has been labeled with 32P from gamma-32P-ATP and drives ATP-dependent Cd2+ uptake by inside-out membrane vesicles. Recently isolated genes defective in the human hereditary diseases of copper metabolism, Menkes syndrome and Wilson's disease, encode P-type ATPases that are more similar to the bacterial CadA and CopB ATPases than to eukaryote ATPases that pump different cations. The arsenic resistance efflux system transports arsenite, using alternatively either a two-component (ArsA and ArsB) ATPase or a single polypeptide (ArsB) functioning as a chemiosmotic transporter. The third gene in the arsenic resistance system, arsC, encodes an enzyme that converts intracellular arsenate [As (V)] to arsenite [As (III)], the substrate of the efflux system. The three-component Czc (Cd2+, Zn2+, and CO2+) chemiosmotic efflux pump of soil microbes consists of inner membrane (CzcA), outer membrane (CzcC), and membrane-spanning (CzcB) proteins that together transport cations from the cytoplasm across the periplasmic space to the outside of the cell. Finally, the first bacterial metallothionein (which by definition is a small protein that binds metal cations by means of numerous cysteine thiolates) has been characterized in cyanobacteria.
Hardware/software selected cycle solution (1994)

For many system designs where hardware and software are co-dependent, there often exists a design bottleneck where most of the hardware design has to be completed and fabricated before meaningful software verification can begin. In some sectors of electronic design where competitive markets require that the design cycle has to be completed quickly-mobile phone handsets and image decoders, for instance-having the software ready and substantially debugged as soon as the hardware is ready can give a significant competitive advantage. This paper describes a methodology that allows practical hardware/software co-simulation to achieve meaningful software verification early in the design cycle. The technique allows software development and testing to be more concurrent with the hardware development by using simulated models of the hardware design to interact with the software programs. A high level of performance is achieved by using the simulated description on selected target processor cycles only. Only the important bus cycles are simulated in the hardware simulator. >
PAA-PAMPS Copolymers as an Efficient Tool to Control CaCO<sub>3</sub> Scale Formation (2013)

Scale formation, the deposition of certain minerals such as CaCO3, MgCO3, and CaSO4·2H2O in industrial facilities and household devices, leads to reduced efficiency or severe damage. Therefore, incrustation is a major problem in everyday life. In recent years, double hydrophilic block copolymers (DHBCs) have been the focus of interest in academia with regard to their antiscaling potential. In this work, we synthesized well-defined blocklike PAA-PAMPS copolymers consisting of acrylic acid (AA) and 2-acrylamido-2-methyl-propane sulfonate (AMPS) units in a one-step reaction by RAFT polymerization. The derived copolymers had dispersities of 1.3 and below. The copolymers have then been investigated in detail regarding their impact on the different stages of the crystallization process of CaCO3. Ca(2+) complexation, the first step of a precipitation process, and polyelectrolyte stability in aqueous solution have been investigated by potentiometric measurements, isothermal titration calorimetry (ITC), and dynamic light scattering (DLS). A weak Ca(2+) induced copolymer aggregation without concomitant precipitation was observed. Nucleation, early particle growth, and colloidal stability have been monitored in situ with DLS. The copolymers retard or even completely suppress nucleation, most probably by complexation of solution aggregates. In addition, they stabilize existing CaCO3 particles in the nanometer regime. In situ AFM was used as a tool to verify the coordination of the copolymer to the calcite (104) crystal surface and to estimate its potential as a growth inhibitor in a supersaturated CaCO3 environment. All investigated copolymers instantly stopped further crystal growth. The carboxylate richest copolymer as the most promising antiscaling candidate proved its enormous potential in scale inhibition as well in an industrial-filming test (Fresenius standard method).
The Deep Model (2015)

“The Model” (a.k.a. “TM”, Dailey and Cottrell, 1999) is a biologically-plausible neurocomputational model designed for face and object recognition. Developed over the last 25 years, TM has been successfully used to model many cognitive phenomena, such as facial expression perception (Dailey et al., 2002), recruitment of the FFA for other categories of expertise (Tong et al., 2008), and the experience moderation effect on the correlation between face and object recognition (Wang et al., 2014). However, as TM is a “shallow” model, it cannot develop rich feature representations needed for challenging computer vision tasks. Meanwhile, the recent deep convolutional neural network techniques produce state-of-the-art results for many computer vision benchmarks, but they have not been used in cognitive modeling. The deep architecture allows the network to develop rich high level features, which generalize really well to other novel visual tasks. However, the deep learning models use a fully supervised training approach, which seems implausible for early visual system. Here, “The Deep Model” (TDM) tries to bridge TM and deep learning models together to create a “gradually” supervised deep architecture which can be both biologically-plausible and perform well on computer vision tasks. We show that, by using the sparse PCA and RICA algorithms on natural image datasets, we can obtain center surround color-opponent receptive field that represent LGN cells, and Gabor-like filters that represent V1 simple cells. This suggests that the unsupervised learning approach is what is used in the development of the early visual system. We employ this insight to develop a gradually supervised deep neural network and test it on some standard computer vision and cognitive modeling tasks. Meeting abstract presented at VSS 2015
Design and Performance of a Pinned Photodiode CMOS Image Sensor Using Reverse Substrate Bias (2018)

A new pinned photodiode (PPD) CMOS image sensor with reverse biased p-type substrate has been developed and characterized. The sensor uses traditional PPDs with one additional deep implantation step to suppress the parasitic reverse currents, and can be fully depleted. The first prototypes have been manufactured on an 18 µm thick, 1000 Ω·cm epitaxial silicon wafers using 180 nm PPD image sensor process. Both front-side illuminated (FSI) and back-side illuminated (BSI) devices were manufactured in collaboration with Teledyne e2v. The characterization results from a number of arrays of 10 µm and 5.4 µm PPD pixels, with different shape, the size and the depth of the new implant are in good agreement with device simulations. The new pixels could be reverse-biased without parasitic leakage currents well beyond full depletion, and demonstrate nearly identical optical response to the reference non-modified pixels. The observed excessive charge sharing in some pixel variants is shown to not be a limiting factor in operation. This development promises to realize monolithic PPD CIS with large depleted thickness and correspondingly high quantum efficiency at near-infrared and soft X-ray wavelengths.
Reassessing lower lid anchoring after 24 years (2005)

The author uses the concepts of preserving the pretarsal orbicularis muscle and anchoring the preseptal muscle to the lateral orbital rim suture as the basis for a cheek lift/eyelid correction. Refinements in his technique have evolved over a period of 24 years and with treatment of more than 1000 patients.
Pharmacological and molecular characterization of muscular cholecystokinin receptors in the human lower oesophageal sphincter (2000)

In vitro cholecystokinin (CCK) contracts the human lower oesophageal sphincter by stimulating muscular receptors. The aim of this study was to characterize the muscular CCK receptor subtypes in the human lower oesophageal sphincter. Twenty-five circular strips from six patients were studied. RNA was extracted, reverse transcribed, and cDNAs were amplified with primers for human CCK-A and B receptors. The potency of the contraction induced by CCK-8, desulphated CCK-8, and gastrin-I, and the effect of the CCK-A (loxiglumide and SR 27897) and the CCK-B (YM022 and L-365 260) specific receptor antagonists were compared. Both CCK-A and CCK-B receptor mRNAs were found in functional lower oesophageal sphincter strips. The potency of the CCK-8 concentration-dependent contraction was two and three orders of magnitude higher than that of desulphated CCK-8 and gastrin-I, respectively. The CCK-8-induced contraction was blocked by the CCK-A receptor antagonists loxiglumide (IC50 11 micromol L-1) and SR 27897 (IC50 74 nmol L-1) but not by CCK-B receptor antagonists (1 micromol L-1). Our data suggest that, although the human lower oesophageal sphincter expresses both CCK-A and CCK-B receptors, the contractile effect of CCK-8 on the circular muscle is mainly due to the activation of CCK-A receptors.
Rise of alternative OTC dispute venues. (2015)

Smyth & Co's Jonathan Cary and Robert Rhoda explain why counterparties are increasingly resorting to alternative venues to resolve disputes under the ISDA Master Agreement
Characterization of a Two-Component High-Affinity Nitrate Uptake System in Arabidopsis. Physiology and Protein-Protein Interaction (2006)

The identification of a family of NAR2-type genes in higher plants showed that there was a homolog in Arabidopsis (Arabidopsis thaliana), AtNAR2.1. These genes encode part of a two-component nitrate high-affinity transport system (HATS). As the Arabidopsis NRT2 gene family of nitrate transporters has been characterized, we tested the idea that AtNAR2.1 and AtNRT2.1 are partners in a two-component HATS. Results using the yeast split-ubiquitin system and Xenopus oocyte expression showed that the two proteins interacted to give a functional HATS. The growth and nitrogen (N) physiology of two Arabidopsis gene knockout mutants, atnrt2.1-1 and atnar2.1-1, one for each partner protein, were compared. Both types of plants had lost HATS activity at 0.2 mm nitrate, but the effect was more severe in atnar2.1-1 plants. The relationship between plant N status and nitrate transporter expression revealed a pattern that was characteristic of N deficiency that was again stronger in atnar2.1-1. Plants resulting from a cross between both mutants (atnrt2.1-1 x atnar2.1-1) showed a phenotype like that of the atnar2.1-1 mutant when grown in 0.5 mm nitrate. Lateral root assays also revealed growth differences between the two mutants, confirming that atnar2.1-1 had a stronger phenotype. To show that the impaired HATS did not result from the decreased expression of AtNRT2.1, we tested if constitutive root expression of a tobacco (Nicotiana plumbaginifolia) gene, NpNRT2.1, previously been shown to complement atnrt2.1-1, can restore HATS to the atnar2.1-1 mutant. These plants did not recover wild-type nitrate HATS. Taken together, these results show that AtNAR2.1 is essential for HATS of nitrate in Arabidopsis.
Controlling the electron energy distribution function of electron beam generated plasmas with molecular gas concentration: I. Experimental results (2013)

This paper, the first in a series of two, presents experimental results demonstrating the control of electron and ion energy distribution functions in electron beam generated processing plasmas by adding trace concentrations of N2 to an Ar background. Measurements of the electron energy distribution function, f0(E), are performed using a Langmuir probe while measurements of the Ar ion energy distribution function are performed using an energy-resolved mass spectrometer. The experimental results agree with modeling results, described in part II of this work, which indicate that inelastic electron collisions with nitrogen molecules provide an energy sink that can be exploited to control the electron energy distribution function.
Premature separation of centromere and aneuploidy: an indicator of high risk in unaffected individuals from familial breast cancer families? (1996)

It is estimated that one in every four women with a first-degree relative affected by breast cancer will develop the disease. Recent evidence suggests that susceptibility to breast cancer can be inherited. We have carried out cytogenetic analysis on PHA-stimulated lymphocyte cultures of breast cancer patients (familial and sporadic), patients with benign breast lesions, unaffected individuals from families with a history of breast cancer and healthy controls. A high incidence of premature separation of centromere (PSC) and aneuploidy was observed in a significant proportion of familial breast cancer patients and patients with fibrocystic disease as well as in some unaffected individuals from breast cancer families. These observations are also supported by cytogenetic analysis of EBV-transformed lymphoblastoid cell lines established from some of these individuals. No such aberrations were detected in the controls. Further, most of the affected and unaffected individuals with these two anomalies also exhibited structural chromosomal aberrations of 1q, 6q, 7q, 16q, 18q, or Xq. Based on these observations, we propose that the presence of both PSC and aneuploidy in lymphocyte cultures of unaffected individuals from breast cancer families can be used as an important predictive parameter to determine the risk of developing cancer.
A real time integrated environment for Motorola 680xx-based VME and FASTBUS modules (1989)

The Software Components Group pSOS operating system kernel and pROBE debugger have been extended to support the Fermilab PAN-DA data acquisition system for a variety of Motorola 680xx-based VME and FASTBUS modules. These extensions include: a multitasking, reentrant implementation of Microtec C/Pascal; a serial port driver for terminal I/O and data transfer; a message reporting facility; and enhanced debugging tools. An overview of the system is given, and the run-time-library reentrancy and process context, the serial port driver, the SYS68K Message Reporter System subroutine package, and the enhanced debugging tools are discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Statistical Treatment of Experimental Data. (1978)

1. Introduction. 2. Probability. 3. Random Variables and Sampling Distributions. 4. Some Important Probability Distributions. 5. Estimation. 6. Confidence Intervals. 7. Hypothesis Testing. 8. Tests on Means. 9. Tests on Variances. 10. Goodness of Fit Tests. 11. Correlation. 12. The Straight Line Through the Original or Through Some Other Fixed Point. 13. The Polynomial Through the Origin or Through Some Other Fixed Point. 14. The General Straight Line. 15. The General Polynomial. 16. A Brief Look at Multiple Regression. Appendices: 1. Drawing a Random Sample Using a Table of Random Numbers. 2. Orthogonal Polynomials in x. References. Index.
A Mathematical Model for the Vroman Effect (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Mathematical Model for the Vroman EffectCharles A. LeDuc, Leo Vroman, and Edward F. LeonardCite this: Ind. Eng. Chem. Res. 1995, 34, 10, 3488–3495Publication Date (Print):October 1, 1995Publication History Published online1 May 2002Published inissue 1 October 1995https://doi.org/10.1021/ie00037a037RIGHTS & PERMISSIONSArticle Views343Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Get e-Alerts Get e-Alerts
Membrane estrogen receptor-α levels in MCF-7 breast cancer cells predict cAMP and proliferation responses (2004)

Rapid mER-alpha-mediated nongenomic signaling cascades generate cAMP and downstream signaling events, which contribute to the regulation of breast cancer cell number.
Chemical reaction in the turbulent wake of a cylinder (1965)

Abstract A rapid, irreversible, second‐order chemical reaction in the turbulent wake of a cylinder was studied. A hypothesis relating the correlation of the fluctuating concentrations directly to the mean concentrations of the reacting species was found applicable, at least, when tested for a pseudo first‐order reaction system. Experimentally, the mean concentration profiles of a colored reactant were obtained with and without reaction by time‐exposure photographs. Since the reactant changed from colored to colorless during reaction, the rate of reaction could be determined directly from the rate of color disappearance. Both the reaction rate and the turbulent intensity divided by the half‐width of the wake were found to be inversely proportional to the distance from the source for x / d values from 35 to 180. This indicates a direct relationship between them. Consequently, the concentration correlation function also may be related directly to the turbulent intensity divided by the wake half‐width. In addition, it is shown that the rate of reaction is faster in the center of the wake than it is toward the edges.