gebhart/patrepeval huggingface dataset:
Nouvelle méthode d'interprétation des thermogrammes pour la détermination de la diffusivité thermique par la méthode impulsionnelle (méthode « flash ») (1982)

Dans la mesure de la diffusivité thermique par la méthode « flash », les pertes thermiques perturbent le thermogramme de la face arrière de l'échantillon. Ces pertes ayant lieu nécessairement après le dépôt d'énergie, la température est d'autant moins perturbée que le temps est proche du temps origine qui est l'instant de l'impulsion. En conséquence, on propose d'effectuer l'identification de la diffusivité par extrapolation pour ce temps origine de la loi de diffusivité apparente obtenue en appliquant au thermogramme l'algorithme d'identification strictement applicable à l'échantillon adiabatique. On montre que le tout début de la montée en température peut être utilisé avec une précision suffisante pour la détermination de la diffusivité, et que la température finale adiabatique peut être évaluée à partir de la montée en température effective sans qu'il soit nécessaire de faire des hypothèses sur les pertes thermiques. Dans ces conditions la méthode proposée est applicable. Pour l'extrapolation, l'évolution de la diffusivité apparente est approchée pratiquement par une régression parabolique aux moindres carrés, chaque point étant pondéré proportionnellement à l'observabilité de la diffusivité qui peut lui être attachée. Après une évaluation théorique de sa précision, la méthode est appliquée à des données expérimentales et ses résultats comparés à ceux obtenus par d'autres méthodes.
The pleckstrin homology domain of Bruton tyrosine kinase interacts with protein kinase C. (1994)

Bruton tyrosine kinase (EC 2.7.1.112) [Btk, encoded by Btk in mice and BTK in humans (formerly known as atk, BPK, or emb)], which is variously mutated in chromosome X-linked agammaglobulinemia patients and X-linked immunodeficient (xid) mice, has the pleckstrin homology (PH) domain at its amino terminus. The PH domain of Btk expressed as a bacterial fusion protein directly interacts with protein kinase C in mast cell lysates. Evidence was obtained that Btk is physically associated with protein kinase C in intact murine mast cells as well. Both Ca(2+)-dependent (alpha, beta I, and beta II) and Ca(2+)-independent protein kinase C isoforms (epsilon and zeta) in mast cells interact with the PH domain of Btk in vitro, and protein kinase C beta I is associated with Btk in vivo. Btk served as a substrate of protein kinase C, and its enzymatic activity was down-regulated by protein kinase C-mediated phosphorylation. Furthermore, depletion or inhibition of protein kinase C with pharmacological agents resulted in an enhancement of the tyrosine phosphorylation of Btk induced by mast cell activation.
A revision of the metabolic disposition of amantadine (1985)

Amantadine is one of the most commonly used drugs for the control of tremor in Parkinson's disease. Additionally, it has an antiviral action in the prevention of type A influenza. It has been previously reported that amantadine is nearly completely eliminated in the urine. No metabolites have been detected. Surprisingly, in a case of amantadine overdose, several metabolites could be identified by gas chromatography/mas spectrometry. This finding prompted us to re-investigate the metabolism of amantadine under a therapeutic dosing regimen. The bulk of the dose was eliminated unchanged. However, eight metabolites could be identified. Besides N-acetylation which is the major metabolic pathway, several rather unusual metabolic pathways were observed: N-methylation, formation of Schiff bases and N-formiates. No metabolites with a hydroxylated adamantane ring system could be detected.
Antibacterial Activity of Acyclic Decapeptide Analogs of Gramicidin S (1960)

Three acyclic decapeptide analogs of gramicidin S, although found to possess antibacterial activity, apparently have modes of action which differ from that of the naturally occurring cyclic antibiotic. In contrast to the immediate action of gramicidin S, one of the decapeptides produced complete bacteriostasis only after several cell divisions had occurred. Furthermore, mixtures of gramicidin S with either of two of the acyclic peptides were synergistic. Some implications of these findings are discussed.
Novel and Efficient Preparation of Precursor [<sup>188</sup>Re(OH<sub>2</sub>)<sub>3</sub>(CO)<sub>3</sub>]<sup>+</sup> for the Labeling of Biomolecules (2005)

A novel and efficient method for preparing 188Re(I) tricarbonyl precursor [188Re(OH2)3(CO)3]+ has been developed by reacting [188Re]perrhenate with Schibli's kit in the presence of borohydride exchange resin (BER) as a reducing agent and an anion scavenger. The precursor was produced in more than 97% yield by reacting a solution of tetrahydroborate exchange resin (BER, 3 mg), borane-ammonia (BH3.NH3, 3 mg), and potassium boranocarbonate (K2[H3BCO2], 3 mg) in 0.9% saline with a solution of sodium perrhenate (Na188ReO4) with up to 50 MBq and concentrated phosphoric acid (85%, 7 microL) at 60 degrees C for 15 min. HPLC and TLC revealed 0% unreacted [188Re]perrhenate ion and <3% of colloidal 188ReO2. Since the precursor is produced with high radiochemical purity and labeling efficiency under the milder conditions than those required for the conventional reducing agents, the latter can be replaced.
Whole-Genome Shotgun Optical Mapping of <i>Deinococcus radiodurans</i> (1999)

A whole-genome restriction map of Deinococcus radiodurans, a radiation-resistant bacterium able to survive up to 15,000 grays of ionizing radiation, was constructed without using DNA libraries, the polymerase chain reaction, or electrophoresis. Very large, randomly sheared, genomic DNA fragments were used to construct maps from individual DNA molecules that were assembled into two circular overlapping maps (2.6 and 0.415 megabases), without gaps. A third smaller chromosome (176 kilobases) was identified and characterized. Aberrant nonlinear DNA structures that may define chromosome structure and organization, as well as intermediates in DNA repair, were directly visualized by optical mapping techniques after gamma irradiation.
Problems Associated with Heat Treating (2014)

Abstract Of the various thermal processing methods for steel, heat treating has the greatest overall impact on control of residual stress and on dimensional control. This article provides an overview of the effects of material- and process-related parameters on the various types of failures observed during and after heat treating of quenched and tempered steels. It describes phase transformations of steels during heating, cooling of steel with and without metallurgical transformation, and the formation of high-temperature transformation products on the surface of a carburized part. The article illustrates the use of carbon restoration on decarburized spring steels. Different geometric models for carbide formation are shown schematically. The article also describes the different microstructural features such as grain size, microcracks, microsegregation, and banding.
Natriuretic Peptides Predict Symptom-Free Survival and Postoperative Outcome in Severe Aortic Stenosis (2004)

In severe AS, natriuretic peptides provide important prognostic information beyond clinical and echocardiographic evaluation. NtBNP independently predicts symptom-free survival, and preoperative NtBNP independently predicts postoperative outcome with regard to survival, symptomatic status, and left ventricular function. Thus, neurohormones may gain particular importance for timing of surgery in asymptomatic severe AS.
A potential cardioprotective role of hepatocyte growth factor in myocardial infarction in rats (2001)

The c-Met/HGF receptor is induced in cardiomyocytes following myocardial infarction and HGF exhibits protective effect on cardiomyocytes against oxidative stress. Our working hypothesis is that HGF may afford myocardial protection from myocardial infarction.
Larval morphology of six species of Afrotropical<i>Agabus Leach</i>1817 (coleoptera Dytiscidae) (1992)

Instar III larvae of the following six Ethiopian species of Agabus Leach 1817 are described for the first time, ambulator-group: A. loeffleri Wewalka & Nilsson 1990; raffrayi-group: A. raffrayi Sharp 1882; ragazzii-group: A. perssoni Nilsson 1992, A. crypticoides Régimbart 1895, A. abessinicus (Zimmermann 1928), and A. galamensis Nilsson 1992. Descriptions are based on larvae collected together with adults. Larvae of the ragazzii-group have urogomphi with numerous secondary spines and all primary setae spiniform. Tergal setae are short and spiniform in the ambulator- and ragazzii- groups, whereas they are long in the raffrayi-group. All species have legs with many secondary spines, and the highest numbers were found in the species of the ragazzii- group.
A Chimeric, Ligand-Binding v- <i>erb</i> B/EGF Receptor Retains Transforming Potential (1987)

Comparison of amino acid sequences from human epidermal growth factor (EGF) receptor and avian erythroblastosis virus erbB oncogene product suggests that v-erbB represents a truncated avian EGF receptor gene product. Although both proteins are transmembrane tyrosine kinases, the v-erbB protein lacks most of the extracellular ligand-binding domain and a 32-amino acid cytoplasmic sequence present in the human EGF receptor. To test the validity of the proposed origin of v-erbB and to investigate the functional significance of the deleted extracellular sequences, a chimeric gene encoding the extracellular and the transmembrane domain of the human EGF receptor joined to sequences coding for the cytoplasmic domain of the avian erbB oncogene product was constructed. When expressed in Rat1 fibroblasts, this reconstituted gene product (HER-erbB) was transported to the cell surface and bound EGF. Its autophosphorylation activity was stimulated by interaction with the ligand. Expression of the HER-erbB chimera led to anchorage-independent cell growth in soft agar and EGF-induced focus formation in Rat1 monolayers. Thus, it appears that v-erbB protein sequences in the chimeric receptor retain their transforming activity under the influence of the human extracellular EGF-binding domain.
Studies on 2, 2&prime;-Biquinoline Derivatives. VII (1962)

Application of ethyl benzoylacetate to o- and m-anisidine, and o- and m-phenetidine gave o- and 2-benzoyl-m-acetanisidide, and o- and 2-benzoyl-m-acetophenetidide, which, together with the corresponding para compound obtained earlier, was cyclized by the action of polyphosphoric acid into 4-phenyl-6-methoxy-, -7-methoxy-8-methoxy, -6-ethoxy, -7-ethoxy-, and -8-ethoxy-carbostyrils. These carbostyrils were heated with phosphoryl bromide to form 2-bromo-4-phenyl-6-, -7-, and -8-methoxyquinolines, and 2-bromo-4-phenyl-6-, -7-, and -8-ethoxyquinolines, which were dimerized to prepare 4, 4′-diphenyl-6, 6′-dimethoxy-, -7, 7′-dimethoxy-, -8, 8′-dimethoxy-, -6, 6′-diethoxy-, -7, 7′-diethoxy-, and -8, 8′-diethoxy-2, 2′-biquinolines.4, 4′-Dimethyl-8, 8′-dimethoxy-2, 2′-biquinoline was treated with hydrobromic acid to form 4, 4′-dimethyl-2, 2′-biquinoline-8, 8′-diol and its reaction with the 7, 7′-diol derivative, with application of benzoyl chloride, afforded 4, 4′-dimethyl-8, 8′- and -7, 7′-bisbenzoyloxy-2, 2′-biquinoline. 4, 4′-Dimethyl-8, 8′-bisacetoxy-2, 2′-biquinoline was obtained by treatment with acetic anhydride.
Syntheses of mono-, bis-, and tris(diisopropylamino)triphenylcyclopropenium ions. Cyclopropenyl analogs of triphenylmethane dyes (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSyntheses of mono-, bis-, and tris(diisopropylamino)triphenylcyclopropenium ions. Cyclopropenyl analogs of triphenylmethane dyesKoichi Komatsu, Robert West, and David StanislawskiCite this: J. Am. Chem. Soc. 1977, 99, 19, 6286–6290Publication Date (Print):September 1, 1977Publication History Published online1 May 2002Published inissue 1 September 1977https://pubs.acs.org/doi/10.1021/ja00461a017https://doi.org/10.1021/ja00461a017research-articleACS PublicationsRequest reuse permissionsArticle Views207Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Splicing of a Novel <i>Androgen Receptor</i> Exon Generates a Constitutively Active Androgen Receptor that Mediates Prostate Cancer Therapy Resistance (2008)

The standard systemic treatment for prostate cancer (PCa) is androgen ablation, which causes tumor regression by inhibiting activity of the androgen receptor (AR). Invariably, PCa recurs with a fatal androgen-refractory phenotype. Importantly, the growth of androgen-refractory PCa remains dependent on the AR through various mechanisms of aberrant AR activation. Here, we studied the 22Rv1 PCa cell line, which was derived from a CWR22 xenograft that relapsed during androgen ablation. Three AR isoforms are expressed in 22Rv1 cells: a full-length version with duplicated exon 3 and two truncated versions lacking the COOH terminal domain (CTD). We found that CTD-truncated AR isoforms are encoded by mRNAs that have a novel exon 2b at their 3' end. Functionally, these AR isoforms are constitutively active and promote the expression of endogenous AR-dependent genes, as well as the proliferation of 22Rv1 cells in a ligand-independent manner. AR mRNAs containing exon 2b and their protein products are expressed in commonly studied PCa cell lines. Moreover, exon 2b-derived species are enriched in xenograft-based models of therapy-resistant PCa. Together, our data describe a simple and effective mechanism by which PCa cells can synthesize a constitutively active AR and thus circumvent androgen ablation.
Applications of Human Motion Tracking: Smart Lighting Control (2013)

This paper presents a smart lighting control system based on human motion tracking. Proper illumination and color temperature depend on human activities. A smart lighting system that provides automatic control of lighting illumination and color temperature needs to track human motion and understand human activities. Infrared and thermal spectrum provides useful information robust to the lighting condition. Depth information can be acquired independently of the lighting condition and it is relatively easy to detect humans independent of their clothing, and skin color. Commercial depth cameras or thermal cameras were used for accurate tracking and for estimating human behavior. The activity modes can be estimated using the human motion tracking results from depth cameras and from thermal cameras. Multiple depth cameras were used to detect human subject motion in a large area. The activity modes such as study mode and watching TV mode were estimated and the illumination and color temperature of the LED lighting system were controlled in real time according to the estimated activity.
A pedagogical approach integrating research and applied learning in a graduate OM course (2009)

This case study of an integrative approach to experiential learning in a graduate level operations and quality management course allowed for achieving high-order learning based on Bloom's Taxonomy by integrating research and applied learning techniques. Students were able to achieve the highest level of cognitive learning, evaluation, by using a combination of research and application to solve a real-world operations management problem, elimination of trans fats in the supply chain for a small hospital in rural Michigan. This paper outlines the methodologies used to apply the operations management concepts using multiple methods.
Hybrid Organic–Inorganic Light‐Emitting Diodes (2011)

The demonstration of colour tunability and high efficiency has brought organic light-emitting diodes (OLEDs) into the displays and lighting market. However, high production costs due to expensive deposition techniques and the use of reactive materials still limit their market entry, highlighting the need for novel concepts. This has driven the research towards the integration of both organic and inorganic materials into devices that benefit from their respective peculiar properties. The most representative example of this tendency is the application of metal oxides in organic optoelectronics. Metal oxides combine properties such as high transparency, good electrical conductivities, tuneable morphology, and the possibility of deposition on large areas with low-cost techniques. The use of metal oxides as charge injection interfaces in OLEDs has also been investigated. Hybrid organic-inorganic light-emitting diodes (HyLEDs) are inverted OLEDs that employ air-stable metal oxides as the charge injection contacts. They are emerging as a potential competitor to standard OLEDs, thanks to their intrinsic air stable electrodes and solution processability, which could result in low-cost, large area, light-emitting devices. This article reviews the short history of this class of devices from its first solid state example published in 2006 to the present achievements. The data presented shed light on the electronic mechanism behind the functioning of HyLEDs and give guidelines for their further optimization.
Nematic liquid crystals and twisted-nematic LCDs (2015)

Since 1970, scientific and technological progress of the twisted-nematic liquid crystal display (TN-LCD) technology and subsequent polarisation-controlled field-effect LCDs strongly depended on the discovery, development and manufacturing of novel nematic liquid crystals. New experimental techniques had to be developed for determining all display-relevant LC-material parameters and correlating them with molecular structural elements and display performance. TN-LCDs with low operating voltage and power consumption, faster response, broader operating temperature range, multiplexability and, last but not least, long lifetime were some of the goals. Progress in LC-material R&D, device physics and display manufacturing broadened the range of TN-LCD applications from seven-segment, directly addressed displays in the early 1970s to increasingly more complex LCDs with higher information content. Examples include super-twisted nematic-LCDs in the 1980s and thin-film transistor-addressed TN-LCD monitors in the 1990s and beyond.
Osmotic pressure inhibition of DNA ejection from phage (2003)

Bacterial viral capsids in aqueous solution can be opened in vitro by addition of their specific receptor proteins, with consequent full ejection of their genomes. We demonstrate that it is possible to control the extent of this ejection by varying the external osmotic pressure. In the particular case of bacteriophage lambda, the ejection is 50% inhibited by osmotic pressures (of polyethylene glycol) comparable to those operative in the cytoplasm of host bacteria; it is completely suppressed by a pressure of 20 atmospheres. Furthermore, our experiments monitor directly a dramatic decrease of the stress inside the unopened phage capsid upon addition of polyvalent cations to the host solution, in agreement with many recent theories of DNA interactions.
Simultaneous Calibration of Odometry and Sensor Parameters for Mobile Robots (2013)

Consider a differential-drive mobile robot equipped with an on-board exteroceptive sensor that can estimate its own motion, e.g., a range-finder. Calibration of this robot involves estimating six parameters: three for the odometry (radii and distance between the wheels) and three for the pose of the sensor with respect to the robot. After analyzing the observability of this problem, this paper describes a method for calibrating all parameters at the same time, without the need for external sensors or devices, using only the measurement of the wheel velocities and the data from the exteroceptive sensor. The method does not require the robot to move along particular trajectories. Simultaneous calibration is formulated as a maximum-likelihood problem and the solution is found in a closed form. Experimental results show that the accuracy of the proposed calibration method is very close to the attainable limit given by the Cramér-Rao bound.
Midclavicular Fracture: Not Just a Trivial Injury (2010)

SUMMARY Background: Conservative treatment was long recommended for midclavicular fractures because of the excellent results that were reported in the 1960’s and 70’s. Recently, however, the rucksack bandage has received competition from surgical treatment. The spectrum of operations ranges from classic plate osteosynthesis to intramedullary techniques and angle-stable implants. Methods: We present and evaluate the current treatment options on the basis of a selective review of the literature. Results: Recent studies have confirmed some long-held concepts and refuted others. The risk of non-union after conservative treatment was previously reported as 1% to 2% but has turned out to be much higher in selected subgroups such as in patients with severe displacement, female patients, and patients of advanced age. Furthermore, new implants and techniques have made surgery safer and more likely to result in bony union. Conclusion: In any case of midclavicular fracture, the type of fracture should be precisely analyzed and an individual treatment strategy should be developed in view of the patient’s particular situation. Current studies show with a high level of evidence (level 1) that patients with dis located fractures benefit from surgery. ►Zitierweise