gebhart/patrepeval huggingface dataset:
5 Gbit/s, +10 dBm lossless transmission in 10 km distributed erbium fibre amplifier (1990)

The first data transmission over a distributed erbium-doped fibre amplifier is reported. A +10 dBm input signal, intensity modulated at 5 Gbit/s has been transmitted without loss or distortion over a 10 km fibre, pumped with a total of 50 mW pump power at 1485 nm.
Electrochemically and DNA-triggered cell release from ferrocene/β-cyclodextrin and aptamer modified dualfunctionalized graphene substrate (2014)

Here we report a dual-functionalized electrochemical substrate to trigger cancer cells release based on the supramolecular interaction between β-cyclodextrin (β-CD) and Fc on clinical trial II aptamer AS1411 functionalized graphene platform. On one hand, the host-guest interaction can be reversible electrochemically controlled to realize cancer cells capture/release, and 1-adamantylamine binding can further amplify this surface change by competing interaction with β-CD. On the other hand, the AS1411 aptamer and its complementary DNA (cDNA) also can be used as a switchable anchor for cell adhesion. Our work gives an example for label-free, multi-functionalized triggered cell release based on aptamer and β-CD/graphene-modified surface and this multi-ways for cell catch-and-release on graphene modified surface also provides their potential biomedical application.
Performance Evaluation of FD-SOI MOSFETS for Different Metal Gate Work Function (2011)

Fully depleted (FD) Silicon on Insulator (SOI) metal oxide Field Effect Transistor (MOSFET) Is the Leading Contender for Sun 65nm Regime. This paper presents a study of effects of work functions of metal gate on the performance of FD-SOI MOSFET. Sentaurus TCAD simulation tool is used to investigate the effect of work function of gates ont he performance FDSOI MOSFET. Specific channel length of the device that had been concentrated is 25nm. From simulation we observed that by changing the work function of the metal gates of FD-SOI MOSFET we can change the threshold voltage. Hence by using this technique we can set the appropriate threshold voltage of FD-SOI MOSFET at same voltage and we can decrease the leakage current, gate tunneling current and short channel effects and increase drive current.
Optical Biosensor for Monitoring Microbial Cells (1994)

The potential of a new optical biosensor, the resonant mirror, for detecting whole cells is demonstrated. Staphylococcus aureus (Cowan-1) cells, which express protein-A at their surface, were detected by binding to human immunoglobulin G (IgG) immobilized on an aminosilane-derivatized sensor surface at concentrations in the range 8 x 10(6)-8 x 10(7) cells/mL. A control S. aureus strain (Wood-46), which does not express protein-A, gave no significant response. Immobilization of the capture ligand on aminosilane surfaces with and without a hydrogel coating of carboxymethyl-dextran was compared. The greatest binding response was observed with non-dextran-coated surfaces. The sensitivity of the technique was increased a 1000-fold by using a human IgG-colloidal gold conjugate (30 nm) in a sandwich assay format. S. aureus (Cowan-1) cells were detected in spiked milk samples at cell concentrations from 4 x 10(3)-1.6 x 10(6) cells/mL using the sandwich assay.
Electrophysiological Deterioration During Long-Duration Ventricular Fibrillation (2000)

These results show a rapid and progressive electrophysiological deterioration during fibrillation, leading to electrical diastole between fibrillation action potentials. This rapid deterioration may explain the decreased probability of successful resuscitation after prolonged fibrillation. Therefore, a greater understanding of cellular deterioration during fibrillation may lead to improved resuscitation methods, including development of specific defibrillator waveforms for out-of-hospital cardiac arrest.
TLR4 signaling pathway in mouse Lewis lung cancer cells promotes the expression of TGF-β1 and IL-10 and tumor cells migration (2014)

The signaling pathways that trigger tumor cell escape from immune surveillance are not understood completely. Toll-like receptors (TLRs) are considered to be expressed in both immune cells and tumor cells. By detecting TLRs expression in mouse Lewis lung cancer (LLC) before and after co-culture with mouse lymphocytes, the authors concluded that LLC cells constitutively expressed TLR1, TLR2, TLR3, TLR4, TLR5, TLR6 and TLR9. Meanwhile, TLR4 expression in LLC cells was the strongest after co-culture with mouse lymphocytes. To investigate the possible roles of TLR4 signaling pathway in LLC, the concentrations of TGF-β1 and IL-10 protein in LLC cells supernatant were detected by ELISA, and the migration of LLC cells were detected by transwell assay after lipopolysaccharide (LPS) stimulation. TLR4 protein expression in LLC cells was also detected after LPS stimulation by FCM. The results indicated that both levels of TGF-β1 and IL-10 protein were significantly increased after LPS stimulation and reached to a maximum at 24 h and 10 μg/mL of LPS. The migrated LLC cells with LPS stimulation were significantly increased and reached to a maximum at 10 μg/mL of LPS. The expression of TLR4 protein was significantly enhanced after 10 μg/mL of LPS stimulation. These results suggest that the activation of TLR4 signaling pathway in lung cancer cells may be involved in tumor escape and progression by promoting the expression of TGF-β1 and IL-10 and tumor cells migration.
Phenylketonuria. Early detection, diagnosis and treatment. (1966)

Phenylketonuria can now be detected during the first few days of life by two reliable mass screening techniques; and its major consequence, severe mental retardation, can be prevented by the early institution of a low phenylalanine diet. Case finding, based on determination of phenylalanine serum levels in newborns before discharge from the hospital, appears to yield an acceptable number of new cases without excessive numbers of false positive or false negative tests at the 4 mg per 100 ml reporting level. Feeding history does not appear to be a major factor in influencing test results. In addition to finding cases of phenylketonuria, newborn blood screening has called attention to another group of infants with hyperphenylalaninemia of other causes. The differential diagnosis in such cases is important because the restrictive diet necessary for patients with phenylketonuria might be harmful to others. Such factors as enzymatic immaturity, heterozygote carriers, maternal enzymatic capacities and other amino-acidemic states must be ruled out by thorough examination. Careful observation, investigation and reporting of experience with these patients will help to eliminate some of the present deficiencies in the knowledge of normal and abnormal amino acid metabolism.
Ortho lithiations of arenesulfonic acids. New methodology for electrophilic aromatic substitutions (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOrtho lithiations of arenesulfonic acids. New methodology for electrophilic aromatic substitutionsGarret D. Figuly and J. C. MartinCite this: J. Org. Chem. 1980, 45, 18, 3728–3729Publication Date (Print):August 1, 1980Publication History Published online1 May 2002Published inissue 1 August 1980https://pubs.acs.org/doi/10.1021/jo01306a041https://doi.org/10.1021/jo01306a041research-articleACS PublicationsRequest reuse permissionsArticle Views1663Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Receiver Architectures for UWB-Based Transmit-Only Sensor Networks (2006)

We are interested in designing a low-cost, ultra-wide-band (UWB) sensor network, that consists of a large number of sensor nodes (SNs), which sense the environment and transmit the resulting data via a wireless radio link to so-called cluster heads (CHs). We focus on low-cost transmit-only SNs; the resulting uncoordinated multiuser-access causes packet collisions. To improve the robustness to packet collision, we propose two novel low-complexity noncoherent receiver architectures: (i) the adaptive CH receiver (CHR) that receives only packets whose signal strength is larger than an adaptive threshold; and (ii) the switching CHR that allows the focus to be switched from a packet of a given SN to a packet from another SN with higher signal strength. Using simulations, we show that the number of received packets during burst periods can be dramatically increased with the adaptive CHR, and even more so with the switching CHR.
A 3-axis surface micromachined ΣΔ accelerometer (2002)

A monolithic 3-axis surface micromachined accelerometer with capacitive sense and feedback circuitry uses three separate proof masses to measure acceleration. Each proof mass has its own set of interface circuitry, all of which are coordinated by an on-chip master clock. By including x-, y-, and z-axis sensors on one chip, this accelerometer provides a single-chip solution for measuring three ofthe six degrees of freedom needed in an inertial measurement unit. The sensor chip is implemented in 2 /spl mu/m CMOS technology.
Photoluminescence properties of metalorganic vapor phase epitaxial Zn3As2 (1999)

The photoluminescence (PL) properties of the II3V2 compound semiconductor Zn3As2, grown by metalorganic vapor phase epitaxy, is investigated in the temperature range of 4.2–350 K. Several lines are reported, believed to be due to acceptors and donor-acceptor complexes in the epitaxial material. From variable temperature PL, the band gap is deduced to be indirect in nature (in contrast to most experimental findings to date which have indicated the band gap to be direct in nature) and ∼25–30 meV larger than the indirect band gap. The direct band gap energy has been extracted from the PL spectra in the range of 110–350 K. A linear relationship is observed in this temperature range with slope dEg/dT=−4.00×10−4 eV/K. PL yielded a value of 1.005 eV for the direct gap at room temperature in good agreement with values between 0.989 and 0.999 eV obtained from transmission and reflection measurements.
Novel Pyrazolopyrimidopyridazinones with Potent and Selective Phosphodiesterase 5 (PDE5) Inhibitory Activity as Potential Agents for Treatment of Erectile Dysfunction (2006)

Pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones and their analogues, potentially useful for the treatment of erectile dysfunction, were synthesized and evaluated as inhibitors of phosphodiesterase 5 (PDE5). Several compounds showed IC50 values in the low nanomolar range, and in particular, compound 5r, displaying high potency toward PDE5 (IC50 = 8.3 nM) and high selectivity versus PDE6 (240-fold) appeared to be a very promising new lead both in comparison with the potent but not selective sildenafil and in comparison with some analogues previously reported by us. SAR studies in this triheterocyclic scaffold led us to conclude that the best arranged groups are a methyl in position 1, a benzyl in position 3, a phenyl in position 9, and a linear four-carbon chain in position 6.
Prenatal growth and development of the modern human labyrinth (2004)

The modern human bony labyrinth is morphologically distinct from that of all other primates, showing derived features linked with vestibular function and the overall shape of the cranial base. However, little is known of how this unique morphology emerges prenatally. This study examines in detail the developing fetal human labyrinth, both to document this basic aspect of cranial biology, and more specifically, to gain insight into the ontogenetic basis of its phylogenetically derived morphology. Forty-one post-mortem human fetuses, ranging from 9 to 29 weeks gestation, were investigated with high-resolution magnetic resonance imaging. Quantitative analyses of the labyrinthine morphology revealed a number of interesting age-related trends. In addition, our findings show that: (1) the prenatal labyrinth attains an adult equivalent size between 17 and 19 weeks gestation; (2) within the period investigated, shape changes to all or most of the labyrinth cease after the 17-19-week size maturation point or after the otic capsule ossifies; (3) fetal cochlea development correlates with the surrounding petrosal morphology, but not with the midline basicranium; (4) gestational age-related rotations of the ampullae and cochlea relative to the lateral canal, and posterior canal torsion are similar to documented phylogenetic trends whereas other trends remain distinct. Findings are discussed in terms of the ontogenetic processes and mechanisms that most likely led, in part, to the emergence of the phylogenetically derived adult modern human labyrinth.
Identification of a Lipase-linked Cell Membrane Receptor for Pigment Epithelium-derived Factor (2006)

Pigment epithelium-derived factor (PEDF) is an extracellular multifunctional protein belonging to the serpin superfamily with demonstrable neurotrophic, gliastatic, neuronotrophic, antiangiogenic, and antitumorigenic properties. We have previously provided biochemical evidence for high affinity PEDF-binding sites and proteins in plasma membranes of retina, retinoblastoma, and CNS cells. This study was designed to reveal a receptor involved in the biological activities of PEDF. Using a yeast two-hybrid screening, we identified a novel gene from pigment epithelium of the human retina that codes for a PEDF-binding partner, which we term PEDF-R. The derived polypeptide has putative transmembrane, intracellular and extracellular regions, and a phospholipase domain. Recently, PEDF-R (TTS-2.2/independent phospholipase A(2) (PLA(2))zeta and mouse desnutrin/ATGL) has been described in adipose cells as a member of the new calcium-independent PLA(2)/nutrin/patatin-like phospholipase domain-containing 2 (PNPLA2) family that possesses triglyceride lipase and acylglycerol transacylase activities. Here we describe the PEDF-R gene expression in the retina and its heterologous expression by bacterial and eukaryotic systems, and we demonstrate that its protein product has specific and high binding affinity for PEDF, has a potent phospholipase A(2) activity that liberates fatty acids, and is associated with eukaryotic cell membranes. Most importantly, PEDF binding stimulates the enzymatic phospholipase A(2) activity of PEDF-R. In conclusion, we have identified a novel PEDF-R gene in the retina for a phospholipase-linked membrane protein with high affinity for PEDF, suggesting a molecular pathway by which ligand/receptor interaction on the cell surface could generate a cellular signal.
Dynamic power management of a system on chip based on AMBA AHB bus (2007)

This paper presents new dynamic voltage scaling and power management architectures for a System on Chip with an AMBA AHB bus. The Power State Machine describing the status of the core follows the recommendations of the ACPI standard. The algorithm controls the power states of each block on the basis of battery status, chip temperature and workload conditions. The DVS and DPM architectures proposed has been described at system level in SystemC. In particular, we investigated the possibility to change clock frequency and supply voltage for each master, slave and bus independently when no transfer is required. A system level analysis has been performed to evaluate the effect of different DVS and DPM algorithms, topologies and architectures on power dissipation and system performances.
Assays for Gene Transfer (1990)

There are, of course, several methods that may be employed to monitor and quantitate successful gene transfer. One can assay for the presence of transferred DNA by a Southern blot of genomic DNA or, if the transferred DNA has some unique sequence feature, by the polymerase chain reaction (PCR) carried out on genomic DNA. One may also monitor successful gene transfer by assaying for mRNA production by the exogenous DNA through Northern analysis of cellular RNA or by RNA-driven PCR. Similarly, protein production can be monitored through the application of either immune precipitation or Western techniques, as well as immunofluorescence analysis or bioassay where appropriate. In this section on assays for gene transfer, I discuss and describe Southern- and PCR-based DNA-detection techniques. I will leave RNA- and protein-detection methods for the next section.KeywordsPolymerase Chain ReactionGene TransferHybridization ConditionNitrocellulose FilterNick TranslationThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Multi-modality tomographic image reconstruction using mesh modeling (2003)

In the proposed approach a mesh model uses information obtained from an anatomical MR image to aid in reconstruction of PET images. The aim is to improve spatial resolution and quantitative accuracy of the PET image by using anatomical boundary information from the MR image. The mesh approach accomplishes this by using spatially adaptive spatial sampling and smoothing in the PET reconstruction. Our preliminary results demonstrate that this mesh-based approach to multi-modality PET reconstruction can achieve good results at low computational cost.
Catalytic Asymmetric Electrophilic α-Aminationof α-Cyanoketones in the Presence of Chiral Palladium Complexes (2008)

The catalytic enantioselective electrophilic α-amination promoted by chiral palladium complexes is described. Treatment of α-cyanoketones with azodicarboxylates as electrophilic amination reagents under mild reaction conditions afforded the corresponding α-amino α-cyanoketones with excellent enantiomeric excesses (81-95% ee).
CMOS circuit verification with symbolic switch-level timing simulation (2001)

Symbolic switch-level simulation has been extensively applied to the functional verification of complementary metal-oxide-semiconductor (CMOS) circuitry. We have extended this technique to account for real-valued data-dependent delay values and have developed a novel mechanism for symbolically computing data-dependent Elmore delays. We present our symbolic simulation and delay calculation algorithms and discuss their application to the timing and functional verification of full-custom transistor-level CMOS circuitry.
Impact of genotype on endocrinal complications of Children with Alpha-thalassemia in China (2017)

Alpha-thalassemia occurs with high frenquency in China. Four common α-globin gene deletion mutations (-SEA, -α3.7, and -α4.2, Haemoglobin Constant Spring (CS) mutation) were identified in Chinese patients. Individuals with alpha-thalassemia syndrome are more often of children. However report on endocrinal complications in children with alpha thalassemia in China are still absent. The present study aimed to investigate the impact of genotype on endocrinal complications in Chinese children. Association analysis between genotype and endocrinal compliaction development was conducted on 200 patients with 200 healthy controls. Hypogonadism was found to be the most prominent endocrinal complications (84.0%) leading to the growth retardation, hypogonadism, diabetes mellitus, hypothyroidism and hypoparathyroidism whose incidence were significantly higher in pateints. (α<sup>CS</sup>α/-SEA) was the main genotype of Alpha thalassemia identified in the patients (37.5%), and patients with the (-α4.2/-SEA) genotype had a higher prevalence of hypogonadism, diabetes mellitus and hypoparathyroidism (P = 0.001, P = 0.001, P < 0.001, respectively).
UPAYA MENURUNKAN POPULASI HAMA PADA BUDIDAYA SISTEM TUMPANG SARI DI LAHAN PASIR PANTAI = REDUCING PEST POPULATION IN MULTIPLE CROPPING SYSTEM ON SANDY COASTAL LAND (2001)

Sandy coastal land is marginal land with promising potential if suitable culture technique was practiced therein. Farmers apply multiple cropping system in utilizing these lands, especially those located in the southern coast of Yogyakarta, viz. Bantul and Kulon Progo regencies. The multiple cropping system successfully address the need of optimizing the land, but in term of synthetic chemical inputs such as fertilizer and pesticides, the farmers still rely heavily on them, which may endanger the system and threaten the environment. Multiple cropping system in itself actually promotes organism's biodiversity, therefore chemical inputs should be used with extra care. This study tries to find out whether multiple cropping system in sandy coastal land has the ability to suppress pests population because of its biodiversity, which will in turn reduce chemical inputs. The study was done in Bantul regency for one planting season, using corn, shallot, chilli pepper and choy-sim in a multiple cropping system, which was subjected to pesticides and no pesticides application. Plant growth, pest population and LER (Land Equivalent ratio) were then determined. The result showed that the multiple cropping system without pesticides produce better than the one with pesticides, as shown by the observed pest population dynamics and the calculated LER values.
Along Track Interferometry Synthetic Aperture Radar (ATI-SAR) Techniques for Ground Moving Target Detection (2006)

Conventional along track interferometric synthetic aperture radar, ATI-SAR, approaches can detect targets with very low radial speeds, but their false alarm rate is too high to be used in ground moving target indication radars. The report proposed a dual-threshold approach that combines the conventional interferometric phase detection and the SAR image amplitude detection in order to reduce the false alarm rate. The concept and performance of the dual-threshold approach were illustrated using the Jet Propulsion Laboratory AirSAR ATI data. A simple two-dimensional blind calibration procedure was proposed to correct the group phase shift induced by the platform's crab angle. MATLAB programs for demonstrating the proposed approach were included.
Sidegating effect of GaAs MESFETs in carbon doped GaAs substrate (1993)

The sidegating effect of GaAs MESFETs in carbon doped semi-insulating GaAs substrate was investigated. Measurement results suggest that both the hole injection at one part of the gate electrode, and the modulation of the width of the depletion layer near the interface between the channel and substrate, cause the sidegating effect of GaAs MESFETs. Also, with the increase of carbon concentration, the latter cause becomes dominant in the sidegating effect.
Bilateral controller for teleoperators with time delay via μ-synthesis (1995)

In the standard teleoperator system, force and velocity signals are communicated between a master robot and a slave robot. It is well known that the system can become unstable when even a small time delay exists in the communication channel. In this paper, a method based on the /spl Hscr//sub /spl infin//-optimal control and /spl mu/-synthesis frameworks is introduced to design a controller for the teleoperator that achieves stability for a prespecified time-delay margin while optimizing performance specifications. A numerical design example is included.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>