gebhart/patrepeval huggingface dataset:
The bundle‐forming pili of enteropathogenic <i>Escherichia coli</i>: transcriptional regulation by environmental signals (1996)

The bundle-forming pili (BFP) of enteropathogenic Escherichia coil (EPEC) are required for the development of circumscribed colonies of bacteria attached to the surfaces of cultured epithelial cells, a process termed the localized adherence (LA) phenotype. Similar lesions are evident in jejunal biopsies from EPEC-infected children. BFP production is not constitutive, but instead occurs upon transfer of bacteria from nutrient broth to tissue culture media, indicating that the expression of BFP may be environmentally regulated. To learn more about how BFP protein expression is induced during epithelial-cell adherence, bfpA-cat transcriptional fusions and northern blot analyses were employed to monitor bfpA expression as a function of environmental signals and growth kinetics. bfpA expression was found to be regulated at the transcriptional level, and to require a separate locus on the EPEC adherence factor (EAF) plasmid. Expression occurred selectively during exponential-growth phase and was greatest between 35 and 37 degrees C, and in the presence of calcium. Ammonium (20 mM) significantly reduced bfpA mRNA and protein expression and the development of the LA phenotype. Analysis of the bfpA upstream sequence and identification of the transcription initiation site revealed a conventional sigma (70)-dependent promoter and an AT-rich tract that might affect promoter activity. Taken together, these findings further support the pathogenic role of BFP by explaining how BFP production would commence in the small intestine and terminate in the colon and in external habitats.
Quantitative and compositional changes in high density lipoprotein subclasses in patients with various genotypes of cholesteryl ester transfer protein deficiency (1997)

High density lipoprotein (HDL) with and without apolipoprotein (apo) E was quantified and characterized in subjects with three genotypes of cholesteryl ester transfer protein (CETP) deficiency: the nonsense mutation in intron 14 (10 homozygotes and 5 heterozygotes); the missense mutation in the exon 15 (3 homozygotes and 9 heterozygotes); and the Int14A/D442G in 6 compound heterozygotes. ApoE-poor and apoE-rich HDL-cholesterol levels were elevated significantly in all genotypic groups with the decrease in CETP activity, indicating that both types of HDL-cholesterol can be a substrate for CETP. However, an unchanged or only slightly increased serum apoA-II level in each genotype indicated that the HDL particles with apoA-II are relatively resistant to CETP-mediated lipid transfer. Serum apoE-rich HDL level was considerably higher in the Int14A homozygotes than in the compound heterozygotes, in spite of similar apoE-poor HDL-cholesterol levels, which may indicate that apoE-rich HDL is a better substrate for CETP than apoE-poor HDL. Although the apoE-rich and apoE-poor HDL subclasses were similar in the accumulation of cholesteryl ester and depletion of triglyceride, the accumulation of free cholesterol was unique to apoE-rich HDL, indicating inhibited cholesterol esterification on this lipoprotein. Clinical laboratories should be aware of the discrepancy in HDL-cholesterol measurements that comes from the different recoveries of apoE-rich HDL using commercial reagents. In conclusion, CETP deficiency causes considerable quantitative and compositional changes in HDL subclasses, reflecting a significant physiological role for CETP in HDL metabolism.
Fabrication of wavelength-flattened tapered couplers using polishing for cladding removal (1988)

Wavelength-flattened fused tapered couplers have been fabricated with low loss using a new technique. The asymmetry between the constituent fibres is induced by the rapid removal of a small amount of the cladding of one of the fibres with a polishing wheel.
Self-Organizing Collective Robots with Morphogenesis in a Vertical Plane. (1999)

This paper presents a novel concept of self-organizing collective robots with morphogenesis in a vertical plane.For physical reconfiguration of a swarm of robots against gravity, new types of mechanisms and control strategies are proposed and demonstrated.Basic feasibility of the mechanisms was confirmed through an experiment adopting four prototype robots.Each robot is composed of a body and a pair of arms.The body is equipped with permanent magnets for bonding with another robot.The arms change the bonding configuration by rotating and sliding motions.As for the control strategies, we proposed algorithms which can generate specific global formations of robots from local and minimum interactions between neighboring robots.It is shown that the proposed algorithms can successfully conduct the swarm of robots to the predetermined configurations.
Effects of dextran sulfate on stabilization of milk lipoprotein lipase and VLDL triglyceride hydrolysis in vitro. (1986)

The effects of dextran sulfate (DS), which has various molecular numbers, on hydrolysis of very low density lipoprotein triglyceride (VLDL-TG) by bovine milk lipoprotein lipase (LPL) and the stability of LPL were studied. VLDL-TG hydrolysis was increased by the addition of DS; DS caused linear increase in the Vmax for VLDL-TG with increase in its sulfate content, but did not change the Km value for VLDL-TG. DS also stabilized LPL, but this effect was not dependent on its sulfate content. These results suggest that the mechanism of action of DS in LPL stabilization may be different from that in enhancement of VLDL hydrolysis.
Transform Methods for the Reduction of the Peak to Average Power Ratio for the OFDM Signal (2017)

The paper presents multitransform OFDM-OP system for an effective PAPR (peak to average power ratio) reduction that has a reasonable computational requirement, does not introduce any distortion, needs relatively insignificant decrease in the bandwidth efficiency, and provides a PAPR very close to that for the single carrier modulation systems thus effectively eliminating any PAPR penalty incurred by the multicarrier OFDM system. The PAPR system consists of a bank of multiple orthonormal transforms and a minimum PAPR evaluation unit for finding the optimum transform index. The paper also presents a hybrid OFDM-OP-DSI system comprised of the multiple transforms and a novel dummy symbol insertion. The PAPR reduction performance of the presented systems is compared with those of the various other transform techniques of the literature. Various simulations on the presented systems show that these can achieve a PAPR that is very close to that of a single carrier system for QAM modulation with the order of modulation selected to be 16, 64, and 256.
Direct sequencing is a reliable assay with good clinical applicability for KRAS mutation testing in colorectal cancer (2013)

Direct sequencing showed similar mutation rate as the detection kit and hence can be used effectively and reliably for clinical screening of somatic tumor gene mutations.
University papers in the transactions of the American Nuclear Society (ANS) (1976)

Tenascin-C (TNC) is an extracellular matrix glycoprotein which is frequently up-regulated in a variety of pathological conditions including chronic inflammation and cancer. TNC has been implicated in the modulation of cell migration, proliferation, invasion and angiogenesis. Multiple isoforms of TNC can be generated through the alternative splicing of nine exons located in the fibronectin type III region of the molecule. The profile of isoforms expressed differs between cancers and normal breast, with the fully truncated TNC isoform being predominant in normal and benign tissues and higher molecular weight isoforms induced predominantly in cancer. The addition of extra domains within the fibronectin type III repeat domain greatly affects TNC function with multiple exon combinations available for splicing. Exons 14 and 16 are considered to be tumour-associated and have been shown to affect breast cell line invasion and growth in vitro to a greater extent than the full-length TNC isoform. This mini review will provide a summary of the literature to date regarding the expression of TNC isoforms in the breast and also discuss more recent developments in the field regarding exon AD1.
Physiological and ecological studies on the oestrogenic isoflavones in subterranean clover ( <i>T. subterraneum</i> L.) III. Effects of light (1967)

Isoflavone levels in subterranean clover leaves were higher in 13 hr days of natural daylight than in 6 hr days, but length of photoperiod per se had no substantial effect on these levels. In the field, reduction of light intensity (by shading) to 40% daylight caused no decline in isoflavone levels compared with full daylight; even at 24% daylight the reduction in levels was ill defined. On the other hand, in young seedlings there was a marked fall in isoflavone content, especially in the unifoliate leaf, as light intensity fell from 950 to 320 f.c. However, appreciable isoflavone formation was found in dark-grown clover seedlings. Possible light reactions connected with the promotion of isoflavone synthesis are discussed. Changes in isoflavone levels resulting from variation in the natural light environment are unlikely to be sufficient to affect "clover disease".
Reactions in dry media. Cleavage of carbon-carbon single bonds by ozonation (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions in dry media. Cleavage of carbon-carbon single bonds by ozonationDaniel Tal, Ehud Keinan, and Yehuda MazurCite this: J. Am. Chem. Soc. 1979, 101, 2, 502–503Publication Date (Print):January 1, 1979Publication History Published online1 May 2002Published inissue 1 January 1979https://pubs.acs.org/doi/10.1021/ja00496a049https://doi.org/10.1021/ja00496a049research-articleACS PublicationsRequest reuse permissionsArticle Views140Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Impact of Omega-3 Fatty Acids on Depressive Disorders and Suicidality: Can We Reconcile 2 Studies With Seemingly Contradictory Results? (2011)

Article AbstractDr. Mischoulon comments on 2 articles, Lewis et al and Sublette et al. He contrasts these 2 studies and then reconciles their findings, pointing out that they are not mutually exclusive.
Candlestick oven with a silica wick provides an intense collimated cesium atomic beam (2007)

This article shows that readily available glass and silica fibers and braids are suitable capillary structure for recirculating ovens, such as candlestick ovens, becoming then an alternative wick material to conventional metal based capillary structures. In order to study wettability and capillarity of metallic liquid cesium on borosilicate and silica microstructures, samples were selected, prepared, and tested experimentally. The contact angle of cesium on silica glass was roughly measured: theta = 35 degrees - 10 degrees. A commercially available silica braid was then introduced inside a candlestick oven to transfer the metallic liquid cesium from the cold reservoir to the hot emission point of the candlestick. A collimated cesium atomic beam of intensity of 2 x 10(16) at./s sr was obtained, stable and reproducible. Furthermore, this modified ovenis easy to handle daily.
VAULT (2018)

Intel's SGX offers state-of-the-art security features, including confidentiality, integrity, and authentication (CIA) when accessing sensitive pages in memory. Sensitive pages are placed in an Enclave Page Cache (EPC) within the physical memory before they can be accessed by the processor. To control the overheads imposed by CIA guarantees, the EPC operates with a limited capacity (currently 128 MB). Because of this limited EPC size, sensitive pages must be frequently swapped between EPC and non-EPC regions in memory. A page swap is expensive (about 40K cycles) because it requires an OS system call, page copying, updates to integrity trees and metadata, etc. Our analysis shows that the paging overhead can slow the system on average by 5×, and other studies have reported even higher slowdowns for memory-intensive workloads. The paging overhead can be reduced by growing the size of the EPC to match the size of physical memory, while allowing the EPC to also accommodate non-sensitive pages. However, at least two important problems must be addressed to enable this growth in EPC: (i) the depth of the integrity tree and its cacheability must be improved to keep memory bandwidth overheads in check, (ii) the space overheads of integrity verification (tree and MACs) must be reduced. We achieve both goals by introducing a variable arity unified tree (VAULT) organization that is more compact and has lower depth. We further reduce the space overheads with techniques that combine MAC sharing and compression. With simulations, we show that the combination of our techniques can address most inefficiencies in SGX memory access and improve overall performance by 3.7×, relative to an SGX baseline, while incurring a memory capacity over-head of only 4.7%.
New phosphorus‐containing quinone derivatives (2012)

Abstract A variety of new aromatic diols substituted with two (similar and different) phosphorus groups were synthesized via the Michael‐type addition of a PH bond containing reagents to p ‐benzoquinone, reoxidation and the subsequent addition of a second phosphorus unit. In all studied cases, 2,3‐substituted products were obtained exclusively. The resulting hydroquinone derivatives were further investigated regarding rearrangements under basic conditions. © 2012 Wiley Periodicals, Inc. Heteroatom Chem 23:383–394, 2012; View this article online at wileyonlinelibrary.com . DOI 10.1002/hc.21028
A migration approach towards a SOA-based next generation process control and monitoring (2011)

Interest in Service Oriented Architectures (SOA) in the automation domain has seen a rapid increase both from the academia as well as the industry recent years. Since green field plants today are not common, the partial migration of plant automation to SOA design is needed to introduce new functionalities. Thus strategies and approaches for migration from legacy to SOA architectures becomes of vital interest. This paper discusses different views on partial migration of a process monitoring and control system from legacy to SOA. The discussion includes a global top down view, a bottom up view, hardware/software considerations and a hint on training of personnel.
Ornithine Cyclodeaminase:  Structure, Mechanism of Action, and Implications for the μ-Crystallin Family<sup>,</sup> (2004)

Ornithine cyclodeaminase catalyzes the conversion of L-ornithine to L-proline by an NAD(+)-dependent hydride transfer reaction that culminates in ammonia elimination. Phylogenetic comparisons of amino acid sequences revealed that the enzyme belongs to the mu-crystallin protein family whose three-dimensional fold has not been reported. Here we describe the crystal structure of ornithine cyclodeaminase in complex with NADH, refined to 1.80 A resolution. The enzyme consists of a homodimeric fold whose subunits comprise two functional regions: (i) a novel substrate-binding domain whose antiparallel beta-strands form a 14-stranded barrel at the oligomeric interface and (ii) a canonical Rossmann fold that interacts with a single dinucleotide positioned for re hydride transfer. The adenosyl moiety of the cofactor resides in a solvent-exposed crevice on the protein surface and makes contact with a "domain-swapped"-like coil-helix module originating from the dyad-related molecule. Diffraction data were also collected to 1.60 A resolution on crystals grown in the presence of l-ornithine. The structure revealed that the substrate carboxyl group interacts with the side chains of Arg45, Lys69, and Arg112. In addition, the ammonia leaving group hydrogen bonds to the side chain of Asp228 and the site of hydride transfer is 3.8 A from C4 of the nicotinamide. The absence of an appropriately positioned water suggested that a previously proposed mechanism that calls for hydrolytic elimination of the imino intermediate must be reconsidered. A more parsimonious description of the chemical mechanism is proposed and discussed in relation to the structure and function of mu-crystallins.
Serodiagnosis of pleuropneumonia using enzyme-linked immunosorbent assay with capsular polysaccharide antigens of Actinobacillus pleuropneumoniae serotypes 1, 2, 5 and 7. (1990)

Capsular polysaccharide antigens of serotypes 1, 2, 5 and 7 of Actinobacillus pleuropneumoniae were used in enzyme-linked immunosorbent assays (ELISAs) to test sera from experimentally infected and field pigs. Specific reactions were found in sera of experimental pigs with antigens of serotypes 1, 5 and 7 whereas the serotype 2 antigen was cross-reactive. A 1:200 serum dilution was used for testing of 300 sera from 21 swine herds in southern Ontario. Cases of pleuropneumonia had occurred in 11 of these herds, but not in the others. The negative cut-off value was the mean optical density at 405 nm (OD405) + three standard deviations (SD) for 16 negative reference sera. Sera from four pigs naturally infected with Actinobacillus suis were tested and found to react to varying degrees with each of the antigens. Therefore a second cut-off value was determined as the mean OD405 + 2 SD for the A. suis sera. Sera which, in the ELISA produced OD readings above the latter cut-off were considered positive for antibodies to A. pleuropneumoniae; those which were lower than the former cut-off were considered negative. Readings between the two cut-off values may have been due to low positive titers or cross-reactivity, possibly with A. suis, and could not be used to predict pleuropneumonia. Of the pleuropneumonia-free herds, none had positive reactors to serotypes 5 or 7, whereas one and two herds had positive reactors to serotypes 1 and 2, respectively. Of the pleuropneumonia positive herds, six had positive reactors to serotype 1, one to serotype 2, four to serotype 5, and eight to serotype 7.
Congenital Central Hypoventilation and Sleep State (1980)

Congenital central hypoventilation (Ondine's curse) is described in an infant with persistant symptoms throughout the first nine months of life. Respiratory control was most severely affected in quiet sleep, although abnormalities were present in rapid eye movement (REM) sleep and while awake. Failure of metabolic control in quiet sleep led to profound hypoventilation. Behavioral or "behavioral-like" inputs in the awake state and REM sleep increased ventilation, but not to expected normal levels. The ventilatory response to inhaled 4% CO2 was markedly depressed in all states.
Hyperthermia‐induced exencephaly in mice: Effect of multiple exposures (1988)

Pregnant LM/Bc female mice were given a 10-minute hyperthermic exposure in a 43 degrees C waterbath during the period of neural tube closure. On day 15.5 of gestation, the females were killed, and the fetuses were examined for exencephaly. Following a single treatment on day 8.0, 8.5, 8.75, or 9.0 of gestation 1.7, 13.6, 2.9, and 0.8% of the respective fetuses displayed exencephaly. With two treatments, one on each of gestational days 8.5 and 8.75, or three treatments, one on each of gestational days 8.5, 8.75, and 9.0, the percentage of exencephalic fetuses increased to 28.3 and 59.3%, respectively. The increased response to multiple treatments was not due to an increase in the number of susceptible embryos but rather was due to the increased number of treatments. The results of this study suggest that with increasing numbers of treatments, the embryo's ability to recover from the hyperthermic exposure is lessened, resulting in an increase in exencephaly.
Effect of misalignment between ultrasound piezoelectric transducers on transcutaneous energy transfer (2013)

This paper presents power transmission performance of the ultrasound-based piezoelectric recharging system for implantable medical devices. The efficiency of the piezoelectric ultrasonic transcutaneous energy transfer system depends on frequency matching of the transmitter and receiver, electrical, mechanical and acoustical impedance characteristics, distance between the transducers, and misalignment. However, it was realized that the angular misalignment between transmitter and receiver was one of key factors to have effect on the power transmission efficiency. As such, misalignment effect of the piezoelectric ultrasound transmitter and receiver on the power transmission efficiency was investigated by theoretical analysis using finite-difference time-domain method. The pressure field variation in the near field was also estimated to examine the influence of the power transfer performance of the ultrasound-based charging system. Analytical results indicate that the transferred power is greatly reduced by voltage cancellation on the receiver from phase shift due to the misalignment. Furthermore, significant acoustic pressure variation in the near field makes the effect of misalignment on power transmission dependent on the receiver location.
Tunable optical transversal filter based on chirpedgratings (1995)

The authors present a new method for realising a continuously tunable reflectively tapped optical transversal filter processor. This is based on the use of long chirped fibre Bragg gratings as tapping elements. A continuously tunable optical notch transversal filter is demonstrated with a decade tuning range, the highest reported to date.
Principles of Data Structure Error Correction (1982)

Error correction in robust data structures is a difficult problem. Several algorithms for correcting structural errors, in certain list and tree structures, are now known. These algorithms have been examined to determine common design features which may prove useful in the design of correction algorithms for other structures. This paper presents a summary of the algorithms studied and the design principles which were derived. The paper is not a "cookbook" for constructing error correction algorithms, but should prove useful to those designing such algorithms. Implications for the design of robust data structures, so that correction may be done easily, are also briefly discussed.
A Prospective Study of Serum Pseudocholinesterase Levels in Patients With Chronic Spinal Pain (2000)

Measurements of quantitative alterations of serum pseudocholinesterase levels may be useful in the treatment of patients with chronic spinal pain.
Experimental results and optical properties of photoresist: Analysis and study of preexposure phenomena (1973)

With a brief survey on the physico-chemical nature of photopolymers, we give the results of our investigations on the sensitivity and response of photoresist.