gebhart/patrepeval huggingface dataset:
Bone Marrow Mesenchymal Stromal Cells to Treat Tissue Damage in Allogeneic Stem Cell Transplant Recipients: Correlation of Biological Markers with Clinical Responses (2014)

Bone marrow mesenchymal stromal cells (BMSCs) have been used to treat acute graft-versus-host disease (GVHD) and other complications following allogeneic hematopoietic stem cell transplantation (SCT). We conducted a phase I trial using third party, early passage BMSCs for patients with steroid-refractory GVHD, tissue injury, or marrow failure following SCT to investigate safety and efficacy. To identify mechanisms of BMSC immunomodulation and tissue repair, patients were serially monitored for plasma GVHD biomarkers, cytokines, and lymphocyte phenotype. Ten subjects were infused a fixed dose of 2 × 10(6) BMSCs/kg intravenously weekly for three doses. There was no treatment-related toxicity (primary endpoint). Eight subjects were evaluable for response at 4 weeks after the last infusion. Five of the seven patients with steroid-refractory acute GVHD achieved a complete response, two of two patients with tissue injury (pneumomediastinum/pneumothorax) achieved resolution but there was no response in two subjects with delayed marrow failure. Rapid reductions in inflammatory cytokines were observed. Clinical responses correlated with a fall in biomarkers (Reg 3α, CK18, and Elafin) relevant for the site of GVHD or tissue injury. The GVHD complete responders survived significantly longer and had higher baseline absolute lymphocyte and central memory CD4 and CD8 counts. Cytokine changes also segregated with survival. These results confirm that BMSCs are associated with rapid clinical and biomarker responses in GVHD and tissue injury. However, BMSCs were ineffective in patients with prolonged GVHD with lower lymphocyte counts, which suggest that effective GVHD control by BMSCs requires a relatively intact immune system.
SYNTHESIS OF 7-BROMO/8,9-DIMETHYLPHENOTHIAZINE SULFONES (2002)

The synthesis of 7-bromo/8,9-dimethylphenothiazine sulfones is reported. 7-Bromo/ 8,9-dimethylphenothiazine sulfones were prepared by the oxidation of their corresponding phenothiazines by 30% hydrogen peroxide in glacial acetic acid. The structure of newly synthesized compounds has been confirmed by the elemental analysis, IR and NMR spectral studies.
Study of the pseudo-color processing for infrared forest-fire image (2010)

Forest-fire hazard is very serious, so at home and abroad they pay great attention to the study of forest-fire, such as the prevention of forest-fire. Processing the forest-fire image of detected by using the technology of pseudo-color to improve the amount of useful information is one of the most important of forest-fire detection. By a full studying of pseudo-color coded to the forest-fire image, it introduces a gray-scale-color transformation algorithm which is based on the local histogram equalization. The algorithm achieved a highlight of important characteristics of forest-fire and an attenuation of unimportant characteristics, it also converts the grayscale images of the forest-fire detector to the color images which are more suitable for our identification. The algorithm improves the accuracy of our analysis of forest-fire.
Immunomodulatory effect of non-viable components of probiotic culture stimulated with heat-inactivated<i>Escherichia coli</i>and<i>Bacillus cereus</i>on holoxenic mice (2014)

The obtained results demonstrate that non-viable fractions of probiotic bacteria, stimulated by other bacterial species, could induce immunostimulatory effects mediated by cytokines and act, therefore, as immunological adjuvants.
The Amount and Distribution of Pigments in Neurons and Glia of the Cerebral Cortex. Autofluorescent and Ultrastructural Studies (1969)

Journal Article The Amount and Distribution of Pigments in Neurons and Glia of the Cerebral Cortex. Autofluorescent and Ultrastructural Studies Get access Kenneth R. Brizzee, PhD, MD, Kenneth R. Brizzee, PhD, MD 2Departments of Neurology, Anatomy, and Pathology, University of Utah College of MedicineSalt Lake City. Search for other works by this author on: Oxford Academic PubMed Google Scholar Pasquale A. Cancilla, MD, Pasquale A. Cancilla, MD 2Departments of Neurology, Anatomy, and Pathology, University of Utah College of MedicineSalt Lake City. Search for other works by this author on: Oxford Academic PubMed Google Scholar Nancy Sherwood, Ph.D., Nancy Sherwood, Ph.D. 3Department of Physiology, University of CaliforniaBerkeley, Calif. Search for other works by this author on: Oxford Academic PubMed Google Scholar Paola S. Timiras, MD, Ph.D. Paola S. Timiras, MD, Ph.D. 3Department of Physiology, University of CaliforniaBerkeley, Calif. Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Gerontology, Volume 24, Issue 2, April 1969, Pages 127–135, https://doi.org/10.1093/geronj/24.2.127 Published: 01 April 1969
Val-BoroPro Accelerates T Cell Priming via Modulation of Dendritic Cell Trafficking Resulting in Complete Regression of Established Murine Tumors (2013)

Although tumors naturally prime adaptive immune responses, tolerance may limit the capacity to control progression and can compromise effectiveness of immune-based therapies for cancer. Post-proline cleaving enzymes (PPCE) modulate protein function through N-terminal dipeptide cleavage and inhibition of these enzymes has been shown to have anti-tumor activity. We investigated the mechanism by which Val-boroPro, a boronic dipeptide that inhibits post-proline cleaving enzymes, mediates tumor regression and tested whether this agent could serve as a novel immune adjuvant to dendritic cell vaccines in two different murine syngeneic murine tumors. In mice challenged with MB49, which expresses the HY antigen complex, T cell responses primed by the tumor with and without Val-boroPro were measured using interferon gamma ELISPOT. Antibody depletion and gene-deficient mice were used to establish the immune cell subsets required for tumor regression. We demonstrate that Val-boroPro mediates tumor eradication by accelerating the expansion of tumor-specific T cells. Interestingly, T cells primed by tumor during Val-boroPro treatment demonstrate increased capacity to reject tumors following adoptive transfer without further treatment of the recipient. Val-boroPro -mediated tumor regression requires dendritic cells and is associated with enhanced trafficking of dendritic cells to tumor draining lymph nodes. Finally, dendritic cell vaccination combined with Val-boroPro treatment results in complete regression of established tumors. Our findings demonstrate that Val-boroPro has antitumor activity and a novel mechanism of action that involves more robust DC trafficking with earlier priming of T cells. Finally, we show that Val-boroPro has potent adjuvant properties resulting in an effective therapeutic vaccine.
Advances in thermal infrared localization: Challenges and solutions (2010)

Indoor localization is one of the necessary components to provide location based services in indoor environments. Over the last years, several indoor localization systems have been proposed; however, most of them require people to wear some kind of tag or emitter. In this paper, a passive indoor localization system is described, which is solely based on passive thermal infrared sensors. Consequently, the thermal radiation of humans can be exploited and no additional tag is required. First, this paper gives a short introduction to passive thermal infrared localization and its challenges. Second, state of the art solutions are presented. This includes a human-assisted semi-automatic calibration algorithm, a thermal infrared simulation environment and a multi-target localization algorithm.
On the seamless interaction between webRTC browsers and SIP-based conferencing systems (2013)

The growing interest in integrating interactive multimedia features into web applications has recently led to the creation of the W3C WebRTC and the IETF RTCWEB working groups. Such groups are jointly defining both the application programming interfaces and the underlying communication protocols for the setup and management of a reliable communication path between any pair of next-generation web browsers. While the ongoing work is focusing on peer-to-peer communication between browsers, engineers are also facing a new issue, associated with the coexistence of legacy SIPbased systems with the upcoming browserenabled architectures. We herein discuss how we tackled such an issue, by first identifying interoperability requirements and then presenting a real-world interoperability example dealing with the integration of RTCWEB clients into an existing standards-based collaboration platform.
The Reactions of Some Polynitrobenzenes with 2-Cyano-2-propyl Radicals<sup>1</sup> (1959)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Reactions of Some Polynitrobenzenes with 2-Cyano-2-propyl Radicals1William P. NorrisCite this: J. Am. Chem. Soc. 1959, 81, 16, 4239–4243Publication Date (Print):August 1, 1959Publication History Published online1 May 2002Published inissue 1 August 1959https://pubs.acs.org/doi/10.1021/ja01525a031https://doi.org/10.1021/ja01525a031research-articleACS PublicationsRequest reuse permissionsArticle Views53Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
EPIDURAL HEMANGIOMA WITH COMPRESSION OF SPINAL CORD (1938)

My purpose in this paper is to present a case of epidural hemangioma with a fatal outcome from compression of the spinal cord. The presence of a hemangioma in the subcutaneous tissue of the same dermatome and a sudden onset of paralysis and sensory changes below this level should have suggested the correct diagnosis. There would have been an expectation of complete recovery if the epidural hemangioma had been removed soon after the onset of symptoms. Cushing<sup>1</sup>in 1906 cited three cases of his own and three from the literature in which facial hemangiomas were associated with vascular tumors of the cerebral meninges. In this article Cushing suggested for the first time that organs other than the skin, but in the same segment of nerve distribution, could be similarly affected. Since the publication of his paper facial hemangiomas and associated intracranial vascular anomalies have been observed many times. Cobb
Low reflectance terminations and connections for duplex fiber-optic telecommunication links (1981)

The signal-to-noise ratio of full duplex fiber-optic telecommunication links using a single fiber with directional couplers is shown to be extremely sensitive to reflections from fiber end terminations and fiber-to-fiber connections. This paper will examine a series of experimental measurements made to determine the reflectance coefficients of several different end terminations and types of connection.
Low-LET and High-LET Radiation Action of 125 I Decays in DNA: Effect of Cysteamine on Micronucleus Formation and Cell Killing (1995)

Chinese hamster ovary cells were pulse-labeled with 125I-iododeoxyuridine during early S phase, and cell samples were harvested 30 min or 5 h after labeling. The samples were frozen (with or without 25 mM cysteamine) and stored at -196 degrees C for accumulation of 125I decays. X-ray control experiments were performed at 37 degrees C and -196 degrees C. Aliquots of cells were plated for evaluating micronucleus formation and cell survival. The results demonstrated a striking shift in micronucleus formation and cell death with time after labeling. Cells frozen 30 min after labeling exhibited effects typical of low-LET radiation, but cells frozen 5 h after labeling showed a response characteristic of high-LET radiation. Cysteamine provided protection against the effects of 125I during the initial phase of effects characteristic of low-LET radiation, but no protection was seen during the phase characteristic of high-LET radiation. When cell survival was evaluated as a function of micronucleus frequency rather than dose in decays/cell, the survival curves for all treatment groups became superimposed. Previous work using the same experimental system had failed to show a direct link between 125I-induced DNA double-strand breaks and cell death. These findings are consistent with the hypothesis that DNA damage may not be the sole mechanism for cell killing and that damage to higher-order structures in the cell nucleus may contribute to (or modify) radiation-induced cell death.
Inhibition of Telomerase Activity by Preventing Proper Assemblage (2003)

Telomerase is a ribonucleoprotein complex that acts as a reverse transcriptase in the maintenance of chromosome ends. Because the vast majority of cancer cells require telomerase activity, telomerase has become a target for anticancer drug discovery. Here, we describe a new approach for targeting telomerase by blocking the association between the telomerase catalytic subunit, hTERT, and key elements of the human telomerase RNA subunit, hTR. By examining the effects of oligonucleotides that hybridize to various regions of hTR, we identified two regions of the RNA subunit that are sensitive to molecular interactions leading to telomerase inhibition. Oligonucleotides that hybridize to either the P3/P1 pairing region or to the CR4-CR5 domain of hTR, hTRas009, and hTRas010, respectively, inhibit telomerase activity when added to recombinant hTERT and hTR prior to assemblage. However, addition of hTRas009 or hTRas010 to preassembled telomerase resulted in little or no inhibition. We also examined the ability of hTRas009 and hTRas010 to inhibit binding of hTR and hTR fragments to hTERT. We found that hTRas009 inhibited approximately 50% of the maximum binding between the pseudoknot fragment of hTR (nucleotides 46-209) and hTERT, whereas hTRas010 inhibited over 90% of the maximum binding between the CR4-CR5 fragment of hTR (nucleotides 243-328) and hTERT. In addition, neither oligonucleotide was able to appreciably inhibit the binding of full-length hTR to hTERT, although both oligonucleotides used in conjunction decreased binding by approximately 50%. We propose that the P3/P1 pairing region and CR4-CR5 domain represent viable targets to inhibit telomerase by perturbing proper assemblage of the active complex.
Left Ventricle Wall Motion Analysis During Various Phases Of Cardiac Cycle From 2D-Echocardiographic Images (2005)

The displacement vectors of the left ventricular wall boundary from 2-D echocardiographi c images at the papillary muscle level in short a xis view have been obtained during seven sequential phases covering the entire cardiac cycle. The displacements w ith b oth magnitude and direction were calculated using optical flow technique for the successive pairs of images and were plotted at the diastolic boundary of the ventricular wall. These diagrams quantitatively depict the movement undergone by the v entricular wall during the different phases. The displacements calculated at various points along the wall boundary show the changes in wall motion during the entire cardiac cycle which could be utilized to detect the left ventricular functional abnormalities in various diseases.
HYDROGEN PICKUP DURING CORROSION TESTING OF ZIRCONIUM AND ZIRCALOY-2 (1953)

Our aim was to measure axial forces in the stomach and to evaluate their relation to circumferential contractions of the gastric walls and the emptying of gastric content. We used a combination of simultaneous radioscintigraphy, gastroduodenal manometry, and an axial force transducer with an inflatable 2-ml balloon fluoroscopically placed in the antrum. In vitro studies demonstrated that the axial force transducer records only antegrade forces along the longitudinal axis of this probe in an intensity-dependent manner. In vivo studies were performed in five healthy subjects for at least 3 h after ingestion of radiolabeled meals. When administered separately, the emptying of liquids or solids from the stomach is associated with generation of antral axial forces and coincident phasic pressure activity; however, almost 20% (average) of gastric axial forces during emptying of liquids or solids are unassociated with proximal or distal antral pressure activity ("isolated" forces). High amplitude antral axial forces and pressures occur during both lag and postlag emptying phases. During emptying of liquids, there is a trend for axial forces to be coincident more often with proximal than with distal antral pressure activity and vice versa for the emptying of solids (P = 0.015). These data suggest that when placed in the antrum, the transducer can semiquantitatively record axial forces during gastric emptying. By combining these observations with the data from in vitro studies, it appears that axial forces predominantly result from traction on the balloon by the longitudinal vector resulting from circumferential gastric contractions. The combination of radioscintigraphy and measurement of antral axial forces is a promising method to evaluate mechanical forces involved in the emptying of the human stomach.
Sensory and intrinsic coordination of movement (1999)

A recently generalized theory of perceptual guidance (general tau theory) was used to analyse coordination in skilled movement. The theory posits that (i) guiding movement entails controlling closure of spatial and/or force gaps between effectors and goals, by sensing and regulating the tau s of the gaps (the time-to-closure at current closure rate), (ii) a principal way of coordinating movements is keeping the tau s of different gaps in constant ratio (known as tau-coupling), and (iii) intrinsically paced movements are guided and coordinated by tau-coupling onto a tau-guide, tau g, generated in the nervous system and described by the equation tau g = 0.5 (t-T 2/t) where T is the duration of the body movement and t is the time from the start of the movement. Kinematic analysis of hand to mouth movements by human adults, with eyes open or closed, indicated that hand guidance was achieved by maintaining, during 80 85% of the movement, the tau-couplings tau alpha-tau r and tau r-tau g, where tau r is tau of the hand-mouth gap, tau alpha is tau of the angular gap to be closed by steering the hand and tau g is an intrinsic tau-guide.
La unificación del régimen de jubilaciones y los principios constitucionales (1999)

La multiplicidad y la facilidad para obtener beneficios de sistemas de jubilaciones en Venezuela es un factor de distorsion de la economia nacional. El primer intento de unificacion y sometimiento a normas de contribucion fue detenido por los Tribunales. Un segundo intento, a traves de la Ley del Subsistema de Pensiones del Sistema de Seguridad Social Integral, debe enfrentarse a derechos adquiridos. Pero la necesidad de seguridad juridica debe balancearse con la igualdad constitucional y el bien comun. En este articulo se dilucidan desde la optica iuspublicista esos problemas.
Rapid Quantification of Human ABCA1 mRNA in Various Cell Types and Tissues by Real-Time Reverse Transcription-PCR (2001)

Our RT-PCR assay allows the specific and highly reproducible detection and quantification of minute amounts of human ABCA1 mRNA. This new method is more accurate, more informative, and less laborious than the classic RT-PCR methods and Northern blot; it therefore could simplify all studies on ABCA1 mRNA expression.
Reduced Neural Habituation in the Amygdala and Social Impairments in Autism Spectrum Disorders (2009)

These results suggest amygdala hyperarousal in autism spectrum disorders in response to socially relevant stimuli. Further, sustained amygdala arousal may contribute to the social deficits observed in autism spectrum disorders.
Simple dc technique for precise electron beam current regulation (1976)

A straightforward dc circuit has been built for the precise regulation and accurate measurement of the total incident beam current in an elastic low-energy electron diffraction (ELEED) apparatus. It functions simply by comparing the returning ground current to a reference current and optically coupling the result to control the filament-to-Wehnelt cylinder potential difference. Beam currents down to 0.1 μA are regulated to within 1% at sweep rates up to 8 v/sec and energy ranges up to 200 eV wide. An additional useful feature is the ability to monitor and null out any leakage or displacement currents without confusion with the true beam current.
A multi-agent approach for peer-to-peer-based information retrieval systems (2004)

This paper develops and analyzes distributed search techniques for use in a peer-to-peer (P2P) network-based Information Retrieval (IR) system. In the absence of a centralized mediator with global knowledge that directs requests to appropriate agents, agents must cooperate to forward the queries among themselves so as to find appropriate agents, and return and merge the results in order to fulfill the information retrieval task in a distributed environment. In our approach, the agent society is connected through an agent-view structure maintained by each agent. Initially, the agent-view structures are formed by agents connecting to each other randomly. However, we show that such an approach can be significantly enhanced by dynamically reorganizing the underlying agent-view topology and deploying contextsensitive distributed search algorithms. Experimental results indicate that appropriate organizational structures and distributed search mechanisms can have a positive influence on system performance.
Professional development for specialist teachers and assessors of students with literacy difficulties/dyslexia: ‘to learn how to assess and support children with dyslexia’ (2013)

In this paper, the results of an investigation into the training needs and expectations of participants of professional development training for specialist teachers and assessors of learners with literacy difficulties and dyslexia are discussed and analysed. The methodology includes both qualitative and quantitative data which were collected over a period of 2 years from participants (N = 75) at the beginning of their courses of study. Current literature is reviewed, and an in‐depth analysis of the findings illuminates the rationale and content of the available training. The author discusses these findings and demonstrates the importance of the training. The conclusions offer research‐based reflections that are important to all those involved in the design and funding of this and future professional development.
Advances in low-loss Nb-Ti strand and cable (2009)

The new fast ramping accelerators will require NbTi conductors with lower ac losses than hitherto. Finer filaments will be needed, which will demand significant improvements in the double stack production process. Eddy current coupling between filaments within the wire must be reduced by increasing the transverse resistivity across the matrix, but this increase must be achieved without increasing the longitudinal resistivity too much. Coupling within cables must be reduced without impeding current sharing between strands. Cored cables offer the best way of achieving this compromise.