gebhart/patrepeval huggingface dataset:
Iterative deconvolution of simultaneous<sup>99m</sup>Tc and<sup>201</sup>Tl projection data measured on a CdZnTe-based cardiac SPECT scanner (2011)

We present a method of correcting self-scatter and crosstalk effects in simultaneous technetium-99m/thallium-201 stress/rest myocardial perfusion (single photon emission computed tomography) SPECT scans. The method, which is in essence a hybrid between the triple energy window method and scatter modelling, is based on a model of spatial and spectral distribution of projection counts in several selected energy windows. The parameters of the model are determined from measurements of thin rod sources in air when no in-object scatter or attenuation effects are present. The model equations are solved using the iterative maximum likelihood expectation maximization algorithm in the projection space to find estimates of the primary photopeak counts of both radionuclides. The method has been developed particularly for a novel dedicated cardiac camera based on CdZnTe pixellated detectors, although it can also be adapted to a conventional scintillator camera. The method has been validated in anthropomorphic phantom experiments. Significant improvement in defect contrast has been observed with only moderate increase in image noise. The application of the method to patient data is illustrated.
Stitching together Multiple Data Dimensions Reveals Interacting Metabolomic and Transcriptomic Networks That Modulate Cell Regulation (2012)

Cells employ multiple levels of regulation, including transcriptional and translational regulation, that drive core biological processes and enable cells to respond to genetic and environmental changes. Small-molecule metabolites are one category of critical cellular intermediates that can influence as well as be a target of cellular regulations. Because metabolites represent the direct output of protein-mediated cellular processes, endogenous metabolite concentrations can closely reflect cellular physiological states, especially when integrated with other molecular-profiling data. Here we develop and apply a network reconstruction approach that simultaneously integrates six different types of data: endogenous metabolite concentration, RNA expression, DNA variation, DNA-protein binding, protein-metabolite interaction, and protein-protein interaction data, to construct probabilistic causal networks that elucidate the complexity of cell regulation in a segregating yeast population. Because many of the metabolites are found to be under strong genetic control, we were able to employ a causal regulator detection algorithm to identify causal regulators of the resulting network that elucidated the mechanisms by which variations in their sequence affect gene expression and metabolite concentrations. We examined all four expression quantitative trait loci (eQTL) hot spots with colocalized metabolite QTLs, two of which recapitulated known biological processes, while the other two elucidated novel putative biological mechanisms for the eQTL hot spots.
Health-related Behaviors in Korea: Smoking, Drinking, and Perinatal Care (1992)

The prevalence of major health-related behaviors and the relationship of these factors with selected sociodemographic factors were studied in South Korea. Subjects studied were household heads and their wives from 989 households. Age-standardized prevalences of smoking were 74.8% and 2.9% for men and women respectively, with no urban-rural difference. There was a tendency of younger or less-educated men smoking more heavily. The prevalence of use of alcoholic drinks were 79.8% and 26.0% for men and women respectively. More drinking was associated with a younger age and higher level of education. The mean prevalences of prenatal care, clinic or hospital delivery, and breastfeeding were 75.0%, 62.6%, and 75.2% respectively in the urban area, whereas the corresponding rates were 63.0%, 50.9%, and 81.1% in the rural area. Higher rates in prenatal care and hospital delivery were associated with a younger age and higher educational level, while breastfeeding showed the opposite trend.
BDCA-2 (CD303): a highly specific marker for normal and neoplastic plasmacytoid dendritic cells (2013)

To the editor:

Montes-Moreno et al recently reported the usefulness of SPIB as a novel immunohistochemical marker for supporting the diagnosis of blastic plasmacytoid dendritic cell neoplasm (BPDCN).[1][1] The article highlights the well-recognized difficulty in approaching the diagnosis of BPDCN,
Teleporter: An analytically and forensically sound duplicate transfer system (2009)

This research seeks to minimize the transmission of unnecessary data when sending forensically sound drive images from remote client locations back to a central site. Files such as operating-system files, applications, and media files are likely to exist on many hard drives. The concept combines common data from local stores with unique data from the remote site to create new, forensically sound media images. Data that can be used from local stores need not be sent over the link. The result is substantially reduced amounts of data that must be transmitted between the two sites and stored at the central location. This paper describes Teleporter, a highly optimized file transfer method. The described research will also refine the understanding of the term forensically sound and introduce the term analytically sound.
Diphosphonate Therapy in Nephrocalcinosis (1976)

4 patients with nephrocalcinosis were treated with disodium ethane 1-hydroxy-1, 1-diphosphonate (EHDP) for a period of 13 months. No clinical side-effects were observed and growth proceeded normally. Radiographic changes of osteitis fibrosa cystica developed in 1 child and bone biopsy in 2 children showed defective osteoid mineralisation. It is suggested that EHDP prevented further crystal deposition in 3 children but did not prevent non-calcium stone formation in the 4th child. In view of this and the development of histological and radiographic evidence of osteomalacia and/or secondary hyperparathyroidism in these patients the value of EHDP remains dubious. On the other hand its use may be justified when rapidly increasing calcification is expected, as for example in hyperoxaluria.
Modeling of mechanical systems with lumped elasticity (2002)

Presents a method for the modeling of mechanical systems with lumped elasticity. The main applications of the method concern high speed machine tools and robots with elastic joints. The method can provide the kinematic and dynamic models of such systems. To achieve this goal we adapted some well known tools and notations which are widely used for rigid robots. The inverse dynamic model has to be redefined and developed.
Interactive continuously moving table (iCMT) large field‐of‐view real‐time MRI (2006)

Continuously moving table (CMT) MRI is a new method that is capable of generating 3D, seamless, large field-of-view (FOV) images by acquiring readouts along the patient superior-inferior axis as the subject is translated through the scanner. For applications that require artifact-free images, such as arterial-phase contrast-enhanced (CE) angiography of the legs, a major challenge is to match the MR data acquisition and patient table motion with the dynamics of blood flow in the region of interest (ROI). Instead of restricting the CMT to predetermined constant table speeds, we adopted a more general approach in which the table motion is decoupled from the phase-encoding order. In our approach the table moves adaptively and in response to operator-provided feedback obtained from viewing real-time preview (or fluoroscopic) images. This interactivity is accomplished by integrating high temporal-spatial resolution encoding of the table position with real-time hybrid-space filling and image reconstruction. Experimental results obtained using our prototype interactive CMT (iCMT) system on a peripheral vascular phantom and five healthy volunteers demonstrate the feasibility of this robust and rapid imaging method for acquiring 3D large-FOV continuous images with patient-specific adaptive table motion profiles.
Biodegradation of hydrocarbon contamination by immobilized bacterial cells. (2006)

This study examined the capacity of immobilized bacteria to degrade petroleum hydrocarbons. A mixture of hydrocarbon-degrading bacterial strains was immobilized in alginate and incubated in crude oil-contaminated artificial seawater (ASW). Analysis of hydrocarbon residues following a 30-day incubation period demonstrated that the biodegradation capacity of the microorganisms was not compromised by the immobilization. Removal of n-alkanes was similar in immobilized cells and control cells. To test reusability, the immobilized bacteria were incubated for sequential increments of 30 days. No decline in biodegradation capacity of the immobilized consortium of bacterial cells was noted over its repeated use. We conclude that immobilized hydrocarbon-degrading bacteria represent a promising application in the bioremediation of hydrocarbon-contaminated areas.
Efficacy and safety of once-daily GW870086 a novel selective glucocorticoid in mild-moderate asthmatics: a randomised, two-way crossover, controlled clinical trial (2013)

This total lack of effect suggests that repeat-dose GW8700861 mg has suboptimal efficacy in mild to moderate asthma.
Front-End Electronic Circuit Topology Analysis for Model-Driven Classification and Monitoring of Appliance Loads in Smart Buildings (2012)

This paper presents a nonintrusive appliance load monitoring (NILM) strategy for energy management systems in smart buildings. Compared to purely data-driven methods, this paper introduces a prior-knowledge-based model-driven framework. The prior-knowledge includes front-end power supply circuit identification, electrical operating principle, and customer usage. The focus of this paper is on a comprehensive study on front-end power supply circuit topologies and on the commercial power supply market. The former forms the basis of the proposed hierarchical taxonomy from the power electronics' point of view, and the latter study guarantees that the proposed taxonomy represents the majority of appliance loads in the real world. Under the proposed taxonomy, the advantage of the model-driven hierarchical feature extraction is discussed, and initial analysis shows that optimized features can be obtained from this method, which drives a much simpler AND more feasible solution in differentiating the subtle differences between similar loads.
The ClpXP and ClpAP proteases degrade proteins with carboxy-terminal peptide tails added by the SsrA-tagging system (1998)

Interruption of translation in Escherichia coli can lead to the addition of an 11-residue carboxy-terminal peptide tail to the nascent chain. This modification is mediated by SsrA RNA (also called 10Sa RNA and tmRNA) and marks the tagged polypeptide for proteolysis. Degradation in vivo of lambda repressor amino-terminal domain variants bearing this carboxy-terminal SsrA peptide tag is shown here to depend on the cytoplasmic proteases ClpXP and ClpAP. Degradation in vitro of SsrA-tagged substrates was reproduced with purified components and required a substrate with a wild-type SsrA tail, the presence of both ClpP and either ClpA or ClpX, and ATP. Clp-dependent proteolysis accounts for most degradation of SsrA-tagged amino-domain substrates at 32 degrees C, but additional proteases contribute to the degradation of some of these SsrA-tagged substrates at 39 degrees C. The existence of multiple cytoplasmic proteases that function in SsrA quality-control surveillance suggests that the SsrA tag is designed to serve as a relatively promiscuous signal for proteolysis. Having diverse degradation systems able to recognize this tag may increase degradation capacity, permit degradation of a wide variety of different tagged proteins, or allow SsrA-tagged proteins to be degraded under different growth conditions.
Effect of Abolishment of the Use of Antimicrobial Agents for Growth Promotion on Occurrence of Antimicrobial Resistance in Fecal Enterococci from Food Animals in Denmark (2001)

From 1995 to 2000, a total of 673 Enterococcus faecium and 1,088 Enterococcus faecalis isolates from pigs together with 856 E. faecium isolates from broilers were isolated and tested for susceptibility to four classes of antimicrobial agents used for growth promotion as part of the Danish program of monitoring for antimicrobial resistance. The four antimicrobials were avilamycin, erythromycin, vancomycin, and virginiamycin. Major changes in the use of antimicrobial agents for growth promotion have occurred during the last 6 years in Denmark. The government banned the use of avoparcin in 1995 and of virginiamycin in 1998. Furthermore, the producers have voluntarily stopped all use beginning in 1999. The avoparcin ban in 1995 was followed by a decrease in the occurrence of glycopeptide-resistant E. faecium (GRE) in broilers, from 72.7% in 1995 to 5.8% in 2000. The occurrence of glycopeptide resistance among isolates from pigs remained constant at around 20% from 1995 to 1997. It was shown that, in GRE from pigs, the genes encoding macrolide and glycopeptide resistance were genetically linked and that, following the decrease in the use of tylosin during 1998 and 1999, the occurrence of GRE in pigs decreased to 6.0% in 2000. From 1995 to 1997 the occurrence of erythromycin resistance among E. faecium and E. faecalis isolates from pigs was almost 90%. Use of tylosin decreased considerably during 1998 and 1999, and this decrease was followed by decreases in the occurrence of resistance to 46.7 and 28.1% among E. faecium and E. faecalis isolates from pigs, respectively. Erythromycin resistance among E. faecium isolates from broilers reached a maximum of 76.3% in 1997 but decreased to 12.7% in 2000 concomitantly with more limited use of virginiamycin. Use of virginiamycin increased from 1995 to 1997 and was followed by an increased occurrence of virginiamycin resistance among E. faecium isolates in broilers, from 27.3% in 1995 to 66.2% in 1997. In January 1998 the use of virginiamycin was banned in Denmark, and the occurrence of virginiamycin resistance decreased to 33.9% in 2000. Use of avilamycin increased from 1995 to 1996 and was followed by an increase in avilamycin resistance among E. faecium isolates from broilers, from 63.6% in 1995 to 77.4% in 1996. Since 1996 avilamycin usage has decreased, followed by a decrease in resistance to 4.8% in 2000. Our observations show that it is possible to reduce the occurrence of antimicrobial resistance in a national population of food animals when the selective pressure is removed. Cases in which resistance to vancomycin was linked to resistance to erythromycin were exceptions. In such cases resistance did not decrease until the use of both avoparcin and tylosin was limited.
Rechargeable Li/TiS/sub 2/ AA cells (2002)

Performance characteristics of AA cells based on the Li/TiS/sub 2/ couple and utilizing a proprietary electrolyte are presented and discussed. These general purpose, medium power, AA cells provide 1.0 Ah, have an average discharge voltage of 2.1 V at 23 degrees C, and a service life of 250 full depth of discharge cycles. Their energy density at the C/3 rate is 130 Wh/kg and they can be discharged up to about the C rate without significant loss of capacity. Operating temperatures extend from -20 degrees C to +or-45 degrees C. Their safety is not compromised by electrical abuse provided cell temperatures do not exceed 140 degrees C.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Blur kernel estimation using normalized color-line priors (2015)

This paper proposes a single-image blur kernel estimation algorithm that utilizes the normalized color-line prior to restore sharp edges without altering edge structures or enhancing noise. The proposed prior is derived from the color-line model, which has been successfully applied to non-blind deconvolution and many computer vision problems. In this paper, we show that the original color-line prior is not effective for blur kernel estimation and propose a normalized color-line prior which can better enhance edge contrasts. By optimizing the proposed prior, our method gradually enhances the sharpness of the intermediate patches without using heuristic filters or external patch priors. The intermediate patches can then guide the estimation of the blur kernel. A comprehensive evaluation on a large image deblurring dataset shows that our algorithm achieves the state-of-the-art results.
Site-directed mutagenesis in hemoglobin: test of functional homology of the F9 amino acid residues of hemoglobin α and β chains (2000)

The cysteine residue at F9(93) of the human hemoglobin (Hb A) beta chain, conserved in mammalian and avian hemoglobins, is located near the functionally important alpha1-beta2 interface and C-terminal region of the beta chain and is reactive to sulfhydryl reagents. The functional roles of this residue are still unclear, although regulation of local blood flow through allosteric S-nitrosylation of this residue is proposed. To clarify the role of this residue and its functional homology to F9(88) of the alpha chain, we measured oxygen equilibrium curves, UV-region derivative spectra, Soret-band absorption spectra, the number of titratable -SH groups with p-mercuribenzoate and the rate of reaction of these groups with 4, 4'-dipyridine disulfide for three recombinant mutant Hbs with single amino acid substitutions: Ala-->Cys at 88alpha (rHb A88alphaC), Cys-->Ala at 93beta (rHb C93betaA) and Cys-->Thr at 93beta (rHb C93betaT). These Hbs showed increased oxygen affinities and impaired allosteric effects. The spectral data indicated that the R to T transition upon deoxygenation was partially restricted in these Hbs. The number of titratable -SH groups of liganded form was 3.2-3.5 for rHb A88alphaC compared with 2.2 for Hb A, whereas those for rHb C93betaA and rHb C93betaT were negligibly small. The reduction of rate of reaction with 4,4'-dipyridine disulfide upon deoxygenation in rHb A88alphaC was smaller than that in Hb A. Our experimental data have shown that the residues at 88alpha and 93beta have definite roles but they have no functional homology. Structure-function relationships in our mutant Hbs are discussed.
Frequency behavior and the Mott–Schottky analysis in poly(3-hexyl thiophene) metal–insulator–semiconductor diodes (2001)

Metal–insulator–semiconductor diodes with poly(3-hexyl thiophene) as the semiconductor were characterized with impedance spectroscopy as a function of bias, frequency, and temperature. We show that the standard Mott–Schottky analysis gives unrealistic values for the dopant density in the semiconductor. From modeling of the data, we find that this is caused by the relaxation time of the semiconductor, which increases rapidly with decreasing temperature due to the thermally activated conductivity of the poly(3-hexyl thiophene).
Template-Directed Synthesis of Helical Phenanthroline Cyclophanes (2002)

A helical home for copper: A sequential, in situ desilylation/dimerization/decomplexation protocol has been used to generate helical enyne-bridged heterocycles in a copper(I) templated synthesis. Variable temperature 13C NMR analysis of the copper complex (see calculated structure) indicated the barrier to helical isomerization was 13.6 kcal mol−1, an increase of about 4 kcal mol−1 relative to the uncomplexed cyclophane.
Chemoprevention of Prostate Cancer (2009)

Primary prevention of prostate cancer is a relatively new concept. Through large-scale studies it is possible that we may be able to define better the risk for prostate cancer and identify those who would benefit from an intervention to lower their risk of disease. As risk for prostate cancer is better defined, a number of interventions may eventually be tested. Several interventions are sufficiently mature that they can be implemented in large-scale trials. Diet modification is an intervention that is ready for evaluation. It may also have additional benefits by decreasing mortality from other malignancies and cardiac disease. 5 alpha-reductase inhibitors are also ready for testing. The National Cancer Institute and its clinical cooperative groups have begun a large trial to assess finasteride in the prevention of prostate cancer.
Recombinant adeno-associated virus serotype 4 mediates unique and exclusive long-term transduction of retinal pigmented epithelium in rat, dog, and nonhuman primate after subretinal delivery (2003)

We previously described chimeric recombinant adeno-associated virus (rAAV) vectors 2/4 and 2/5 as the most efficient vectors in rat retina. We now characterize these two vectors carrying the CMV.gfp genome following subretinal injection in the Wistar rat, beagle dog, and cynomolgus macaque. Both serotypes displayed stable GFP expression for the duration of the experiment (6 months) in all three animal models. Similar to the AAV-2 serotype, AAV-2/5 transduced both RPE and photoreceptor cells, with higher level of transduction in photoreceptors, whereas rAAV-2/4 transduction was unambiguously restricted to RPE cells. This unique specificity found conserved among all three species makes AAV-2/4-derived vectors attractive for retinal diseases originating in RPE such as Leber congenital amaurosis (RPE65) or retinitis pigmentosa due to a mutated mertk gene. To provide further important preclinical data, vector shedding was monitored by PCR in various biological fluids for 2 months post-rAAV administration. Following rAAV-2/4 and -5 subretinal delivery in dogs (n = 6) and in nonhuman primates (n = 2), vector genome was found in lacrymal and nasal fluids for up to 3-4 days and in the serum for up to 15-20 days. Overall, these findings will have a practical impact on the development of future gene therapy trials of retinal diseases.
Large radius of curvature micro-lenses on single crystal diamond for application in monolithic diamond Raman lasers (2016)

The design and fabrication of large radii of curvature micro-lenses in single crystal chemical vapour deposition diamond is described. An optimised photoresist reflow process and low selectivity inductively coupled plasma etching are used to actualize a uniform array of micro-lenses with radii of curvature of 13 mm or more and a high quality surface of a root-mean-square roughness of 0.18 nm. The processes developed have the potential to achieve diamond micro-lenses with an even larger radius of curvature. These new diamond micro-lenses enable the pulse energy scalable monolithic diamond Raman laser where a large radius of curvature of the micro-lenses is critical. • Fabrication process of single crystal diamond micro-lenses with large radii of curvature of 13 mm and diameter of 400 mm is developed; • The fabricated diamond micro-lens array has an uniform lens heights and a high etched surface quality; • By mirror coating these micro-lenses to form resonator, a compact and robust monolithic diamond Raman laser is realised.
A Conformational Change in the Catalytic Core of the Hammerhead Ribozyme upon Cleavage of an RNA Substrate (1997)

Heteronuclear multidimensional NMR structural studies have been performed on a hammerhead ribozyme complexed with a cleaved and an uncleaved substrate. The NMR data demonstrate that the three helices surrounding the conserved catalytic core hammerhead are stably formed in both complexes. Evidence is also presented that indicates that the sheared G-A base pairs in the conserved core are formed in the absence of Mg2+. The NMR structural data demonstrate that there is a significant structural change of the conserved core of the hammerhead ribozyme-substrate complex upon cleavage of the substrate. Molecular dynamics calculations were performed to generate models of the ribozyme-cleaved substrate complex, and these results are used to help understand the mechanism of the hammerhead cleavage reaction.