gebhart/patrepeval huggingface dataset:
A Novel 14-Kilodalton Protein Interacts with the Mitogen-Activated Protein Kinase Scaffold Mp1 on a Late Endosomal/Lysosomal Compartment (2001)

We have identified a novel, highly conserved protein of 14 kD copurifying with late endosomes/lysosomes on density gradients. The protein, now termed p14, is peripherally associated with the cytoplasmic face of late endosomes/lysosomes in a variety of different cell types. In a two-hybrid screen with p14 as a bait, we identified the mitogen-activated protein kinase (MAPK) scaffolding protein MAPK/extracellular signal-regulated kinase (ERK) kinase (MEK) partner 1 (MP1) as an interacting protein. We confirmed the specificity of this interaction in vitro by glutathione S-transferase pull-down assays and by coimmunoprecipitation, cosedimentation on glycerol gradients, and colocalization. Moreover, expression of a plasma membrane-targeted p14 causes mislocalization of coexpressed MP1. In addition, we could reconstitute protein complexes containing the p14-MP1 complex associated with ERK and MEK in vitro.The interaction between p14 and MP1 suggests a MAPK scaffolding activity localized to the cytoplasmic surface of late endosomes/lysosomes, thereby combining catalytic scaffolding and subcellular compartmentalization as means to modulate MAPK signaling within a cell.
Role of folic acid in modulating the toxicity and efficacy of the multitargeted antifolate, LY231514. (1998)

We studied the effects of folic acid on modulating the toxicity and antitumor efficacy of LY231514. Using several human tumor cell lines adapted to growth in low folate medium, folic acid was shown to be 100- to 1000-fold less active than folinic acid at protecting cells from LY231514-induced cytotoxicity. The lethality of LY231514 was compared in mice maintained on standard diet or low folate diet. The LD50 occurred at 60- and 250-fold lower doses of LY231514 in DBA/2 and CD1 nu/nu mice, respectively, maintained on low folate diet compared to standard diet. The L5178Y/TK-/HX-murine lymphoma was much more sensitive to the antitumor action of LY231514 compared to wild type L5178Y-S tumors. For mice on low folate diet, LY231514 at 0.3 and 1 mg/kg (qd x 10, i.p.) produced 100% inhibition of L5178Y/TK-/HX-lymphoma growth, and significant lethality occurred at > or = 3 mg/kg. For mice on standard diet, LY231514 produced > 95% inhibition of tumor growth at 30 to 300 mg/kg, but all mice died at 800 mg/kg. Folic acid supplementation was demonstrated to preserve the antitumor activity of LY231514 while reducing toxicity. The combination of folic acid with LY231514 may provide a mechanism for enhanced clinical antitumor selectivity.
Att läsa texter: Några synpunkter på odlandet av prydnadsblommor (2007)

Nyligen utkom den 1475-sidiga antologin Texter (red. Dick Claesson, Lars Fyhr & Gunnar D. Hansson), sammanställd för att ersätta den välanvända men alltmer ålderstigna Litteraturens klassiker på de litteraturvetenskapliga grundutbildningarna. TFL gav två personer i uppdrag att läsa, kommentera och värdera den i flera avseenden tunga boken.
Stochastic cooling in Penning traps (1988)

Stochastic cooling in storage rings was a great success: the present paper gives a complete theory for the application of the same general concepts to Penning traps. The structural difference between a storage ring and a Penning trap requires a complete revision of the starting points on which to base the theory. Not surprisingly, however, the final results exhibit many similarities. One of the main differences is that the noise effects are best treated, in a Penning trap, by introducing a limiting energy ${\ensuremath{\varepsilon}}_{\mathrm{lim}}$, proportional to the noise amplitude, that represents the minimum energy attainable with stochastic cooling. The theory shows that stochastic cooling in a Penning trap can be very useful when one wants rapidly to cool the energy of the trapped particles down to limiting energies greater than kT, T being the noise temperature associated with the detection circuits.
Detection of Glaucoma Progression with Stratus OCT Retinal Nerve Fiber Layer, Optic Nerve Head, and Macular Thickness Measurements (2009)

Stratus OCT RNFL parameters discriminated between eyes progressing by visual fields or optic disc photographs and eyes that remained stable by these methods and performed significantly better than ONH and macular thickness parameters in detecting change over time.
Bioerodible polyphosphazenes and their medical potential (2011)

An account is presented of the development, evaluation, and current status of an unusual series of polymers optimized specifically for biomedical applications. The polymers are based on the polyphosphazene platform with side groups chosen for their ability to sensitize the polymers to hydrolysis to benign small molecules that can be metabolized or excreted from the body. The largest class of these polymers consists of macromolecules with amino acid ester side groups and these are the main focus of the article. However, a variety of polymers with other side groups also show promise as bioerodible species, and these are mentioned later in the article.
Holographic Recording with Photopolymers* (1970)

Phase holograms have been recorded using several photopolymers. These photopolymer recording systems are self-developing and require only uv-light fixing. Sensitivities as high as 0.6 mJ/cm2 have been achieved with He–Ne–laser light. Reconstructions from 3000-line/mm gratings recorded on these materials have been achieved; however, the signal-to-noise ratio falls off above 1500 lines/mm. Microscopy has revealed that the hologram is recorded both on the surface and in the volume of the polymer, and that the surface modulation provides the dominant contribution to the diffraction efficiency for 25-μm-thick films.
Efficient QTL detection for nonhost resistance in wild lettuce: backcross inbred lines versus F2 population (2008)

In plants, several population types [F(2), recombinant inbred lines, backcross inbred lines (BILs), etc.] are used for quantitative trait locus (QTL) analyses. However, dissection of the trait of interest and subsequent confirmation by introgression of QTLs for breeding purposes has not been as successful as that predicted from theoretical calculations. More practical knowledge of different QTL mapping approaches is needed. In this recent study, we describe the detection and mapping of quantitative resistances to downy mildew in a set of 29 BILs of cultivated lettuce (L. sativa) containing genome segments introgressed from wild lettuce (L. saligna). Introgression regions that are associated with quantitative resistance are considered to harbor a QTL. Furthermore, we compare this with results from an already existing F(2) population derived from the same parents. We identified six QTLs in our BIL approach compared to only three in the F(2) approach, while there were two QTLs in common. We performed a simulation study based on our actual data to help us interpret them. This revealed that two newly detected QTLs in the BILs had gone unnoticed in the F(2), due to a combination of recessiveness of the trait and skewed segregation, causing a deficit of the wild species alleles. This study clearly illustrates the added value of extended genetic studies on two different population types (BILs and F(2)) to dissect complex genetic traits.
Object-based human face detection (2002)

We propose an object-based human face detection method. The proposed method consists of two steps: region segmentation and facial region detection. In region segmentation, the input image is segmented by a genetic algorithm into several initial regions. Then, to merge the regions forming an object, we use the spatial similarity between two regions because the regions forming an object share some common spatial characteristics. In facial region detection, the facial regions are identified from the results of the region segmentation step using a skin-color model. This approach can detect multiple faces of multi-views and small size in a complex background environment.
Fetching instruction streams (2002)

Fetch performance is a very important factor because it effectively limits the overall processor performance. However there is little performance advantage in increasing front-end performance beyond what the back-end can consume. For each processor design, the target is to build the best possible fetch engine for the required performance level. A fetch engine will be better if it provides better performance, but also if it takes fewer resources, requires less chip area, or consumes less power. In this paper we propose a novel fetch architecture based on the execution of long streams of sequential instructions, taking maximum advantage of code layout optimizations. We describe our architecture in detail, and show that it requires less complexity and resources than other high performance fetch architectures like the trace cache, while providing a high fetch performance suitable for wide-issue superscalar processors. Our results show that using our fetch architecture and code layout optimizations obtains 10% higher performance than the EV8 fetch architecture, and 4% higher than the FTB architecture using state-of-the-art branch predictors, while being only 1.5% slower than the trace cache. Even in the absence of code layout optimizations, fetching instruction streams is still 10% faster than the EV8, and only 4% slower than the trace cache. Fetching instruction streams effectively exploits the special characteristics of layout optimized codes to provide a high fetch performance, close to that of a trace cache, but has a much lower cost and complexity, similar to that of a basic block architecture.
10 Altered Sensory Function and Balance in Older Persons (1993)

The effects of three different visual inputs (eyes open, eyes closed, and inaccurate) while standing on an unstable surface (respectively, UEO, UEC, UI) were compared in a group of healthy elderly community dwellers (N = 239; mean age 76) and young (N = 34; mean age 34) adults. Subjects with medical factors known to affect balance were excluded. Body sway and loss of balance measured dynamic force platform (EquiTest, NeuroCom International). Visual and somatosensory inputs were rendered inaccurate through tilting of the standing surface and/or the visual surround proportional to the subject's angle of sway (sway-referencing). The elderly group had significantly more difficulty balancing during UEC and UI, and a larger proportion lost their balance during UI. These findings are compared to those of other dynamic posturography studies in which sensory inputs were controlled. Issues of age, frailty, screening, and test protocol are addressed in order to account for differences in results among studies.
Long-Term Oral Polyamine Intake Increases Blood Polyamine Concentrations (2009)

Although the intracellular de novo synthesis of the polyamines decreases with age, there is no similar trend in blood polyamine levels, but rather there is wide individual variability. We hypothesized that dietary polyamines attenuate a decrease in blood polyamine levels with age and augment the previously observed individual variability. The effect of a polyamine rich diet, in both mice and humans, on blood polyamine concentrations was examined in this study. Jc1:ICR male mice were fed test diets containing 3 different polyamine concentrations. Healthy human male volunteers added 50 to 100 g of the polyamine-rich fermented soybean product, natto, to their daily intake. After 26 wk, the mean blood spermine concentration in mice receiving the test diet with high polyamine concentrations was 10.1+/-2.4 micromol/L, while the mean concentrations found in mice fed with a diet with normal or low polyamine concentrations were 5.2+/-0.9 and 4.7+/-0.5 micromol/L, respectively (p<0.05). A mean daily intake of 66.4+/-3.7 g (range=46.4-89.3 g) of natto for 2 mo by human volunteers increased the mean blood spermine concentration by a factor of 1.39 (n=10) (p<0.01), while in control volunteers (n=7), asked to exclude polyamine-rich foods from their diet, blood spermine concentration remained unchanged. The individual variability of blood polyamine levels was enhanced after polyamine intake in mice and, to a lesser extent, in humans. The long-term oral intake of enhanced polyamine diets increases blood polyamine levels in both mice and humans.
Native American mitochondrial DNA analysis indicates that the Amerind and the Nadene populations were founded by two independent migrations. (1992)

Mitochondrial DNAs (mtDNAs) from 167 American Indians including 87 Amerind-speakers (Amerinds) and 80 Nadene-speakers (Nadene) were surveyed for sequence variation by detailed restriction analysis. All Native American mtDNAs clustered into one of four distinct lineages, defined by the restriction site variants: HincII site loss at np 13,259, AluI site loss at np 5,176, 9-base pair (9-bp) COII-tRNA(Lys) intergenic deletion and HaeIII site gain at np 663. The HincII np 13,259 and AluI np 5,176 lineages were observed exclusively in Amerinds and were shared by all such tribal groups analyzed, thus demonstrating that North, Central and South American Amerinds originated from a common ancestral genetic stock. The 9-bp deletion and HaeIII np 663 lineages were found in both the Amerinds and Nadene but the Nadene HaeIII np 663 lineage had a unique sublineage defined by an RsaI site loss at np 16,329. The amount of sequence variation accumulated in the Amerind HincII np 13,259 and AluI np 5,176 lineages and that in the Amerind portion of the HaeIII np 663 lineage all gave divergence times in the order of 20,000 years before present. The divergence time for the Nadene portion of the HaeIII np 663 lineage was about 6,000-10,000 years. Hence, the ancestral Nadene migrated from Asia independently and considerably more recently than the progenitors of the Amerinds. The divergence times of both the Amerind and Nadene branches of the COII-tRNA(Lys) deletion lineage were intermediate between the Amerind and Nadene specific lineages, raising the possibility of a third source of mtDNA in American Indians.
Fischer-Tropsch Synthesis in Slurry Phase (1951)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFischer-Tropsch Synthesis in Slurry PhaseM. D. Schlesinger, J. H. Crowell, Max Leva, and H. H. StorchCite this: Ind. Eng. Chem. 1951, 43, 6, 1474–1479Publication Date (Print):June 1, 1951Publication History Published online1 May 2002Published inissue 1 June 1951https://pubs.acs.org/doi/10.1021/ie50498a057https://doi.org/10.1021/ie50498a057research-articleACS PublicationsRequest reuse permissionsArticle Views133Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Multienzyme system for dihydroxyacetone phosphate-dependent aldolase catalyzed C–C bond formation from dihydroxyacetone (2004)

A multienzyme system composed by recombinant dihydroxyacetone kinase from Citrobacter freundii, fuculose-1-phosphate aldolase and acetate kinase, allows a practical one-pot C-C bond formation catalysed by dihydroxyacetone phosphate-dependent aldolases from dihydroxyacetone and an aldehyde.
The PASM project: a study of reconfigurable parallel computing (2002)

PASM is a concept for a parallel processing system that allows experimentation with different architectural design alternatives. PASM is dynamically reconfigurable along three dimensions: partitionability into independent or communicating submachines, variable interprocessor connections, and mixed-mode SIMD/MIMD parallelism. With mixed-mode parallelism, a program can switch between SIMD (synchronous) and MIMD (asynchronous) parallelism at instruction-level granularity, allowing the use of both modes in a single machine. The PASM concept is presented, showing the ways in which reconfiguration can be accomplished. Trade-offs among SIMD/MIMD, and mixed-mode parallelism are explored. The small-scale PASM prototype with 16 processing elements is described. The ELP mixed-mode programming language used on the prototype is discussed. An example of a prototype-based study that demonstrates the potential of mixed-mode parallelism is given.
statistical approach to non-line-of-sight BS identification (2003)

One of the major challenges to finding accurate mobile terminal location is the non-line-of-sight (NLOS) propagation caused by the blocking of the signal's direct path by obstacles. Traditional location algorithms perform poorly in NLOS environments and this has made it necessary to develop techniques to identify NLOS transmissions and then employ suitable error mitigation techniques. It is extremely difficult to characterize NLOS error because it varies with time and is location specific. We present statistical based techniques to distinguish LOS and NLOS propagation for various scenarios and present simulation results to validate them.
Exploiting Metal Coating of Carbon Nanotubes for Scanning Tunneling Microscopy Probes (2005)

By exploiting the metal coating of carbon nanotube (CNT) tips for a scanning tunneling microscope (STM), we demonstrated atomic imaging/spectroscopy and showed their potential for electrical nanoprobes. A CNT glued to a W tip was uniformly coated with a thin W layer 3–6 nm thick. Using this tip, stable atomic imaging and spectroscopy were carried out on clean Si(111)-7×7 and Si(100)-2×1 surfaces. The mechanical flexibility of the coated CNT was maintained by virtue of the thin-layer coating, enabling repeated direct contact to the sample surface. Two W-coated CNT tips were brought together within a distance of approximately 50 nm. These results indicate that the tips are useful for electronic transport measurements on a nanometer scale after installation into a multiprobe STM.
Branching and bounds tighteningtechniques for non-convex MINLP (2009)

Many industrial problems can be naturally formulated using mixed integer non-linear programming (MINLP) models and can be solved by spatial Branch&Bound (sBB) techniques. We study the impact of two important parts of sBB methods: bounds tightening (BT) and branching strategies. We extend a branching technique originally developed for MILP, reliability branching, to the MINLP case. Motivated by the demand for open-source solvers for real-world MINLP problems, we have developed an sBB software package named couenne (Convex Over- and Under-ENvelopes for Non-linear Estimation) and used it for extensive tests on several combinations of BT and branching techniques on a set of publicly available and real-world MINLP instances. We also compare the performance of couenne with a state-of-the-art MINLP solver.
Vascular endothelial growth factor in primate endometrium is regulated by oestrogen-receptor and progesterone-receptor ligands in vivo (1997)

We investigated hormonal regulation of endometrial angiogenesis in menstruating primates. This study was designed to demonstrate: (i) that cell-specific vascular endothelial growth factor (VEGF) production and expression in monkey endometrium are regulated by steroid receptor ligands; and (ii) mifepristone (RU 486) alters VEGF production even in the absence of a progestin agonist. Endometrial VEGF production was compared by computer-assisted immunohistochemical analysis during induced hypoestrogenism and after oestradiol, progestin, or antiprogestin (mifepristone) treatment. VEGF gene expression was estimated by quantitative reverse-transcriptase polymerase chain reaction (RT-PCR) in endometrial samples from castrate cynomolgus monkeys, from intact monkeys in the luteal phase, and from monkeys treated for 20 days with levonorgestrel (LNG) or mifepristone. VEGF staining intensities in glandular epithelium and VEGF mRNA expression were highest in hypoestrogenic monkeys. Progestin treatment induced intense VEGF staining in the stroma. Gene expression of VEGF-189, but not other isoforms, was higher in progesterone- and progestin (LNG)-exposed endometria compared to mifepristone-exposed endometria or endometria from anovulatory cycles (P < 0.04). Mifepristone abolished VEGF staining in glandular epithelium almost completely. We conclude that VEGF protein and VEGF mRNA expression levels in primate endometrium depend on the steroidal milieu. Anti-angiogenic effects of mifepristone via suppression of VEGF production might represent a mechanism for its quelling effects on endometrium.
Dynamic economic- and QoS-based approach for workflow-oriented distributed services allocation (2005)

With the increasing scale of distributed services in wide-area environment, there are hundreds of thousands of accessible services, which are deployed in heterogeneous, geographically distributed service systems. The processing of services in wide-area environment is also becoming more and more intricate, which promotes the need for linking large-scale distributed computational resources and heterogeneous data resources. The service providers have different price policies and cost models for their services, and varying loads and availability, and also considering about the QoS requirements of service clients, it would require support for dynamic allocation during the process of long running services to achieve the economic cost. In this paper, we propose a dynamic economic- and QoS-based approach for distributed services allocation, which is workflow-oriented. We take the service request as workflow process, which would be achieved by series of element services. The allocation of such element services would be decided dynamically due to the economic objective function (EOF) to address the issues of flexibility, availability, performance, economic cost and QoS requirements in the execution process of services.
Measuring in vivo animal soft tissue properties for haptic modeling in surgical simulation. (2001)

To provide data for the design of virtual environments and teleoperated systems for surgery, it is necessary to measure tissue properties under both in vivo and ex vivo conditions. The former provides information about tissue behavior in its physiological state, while the latter can provide better control over experimental conditions. We have developed devices to measure tissue properties under extension and indentation, as well as to record instrument-tissue interaction forces. We are creating a web database of data recorded from porcine abdominal tissues.