gebhart/patrepeval huggingface dataset:
Transmission of Human Immunodeficiency Virus Type 1 from a Patient Who Developed AIDS to an Elite Suppressor (2008)

Elite suppressors (ES) are untreated human immunodeficiency virus type 1 (HIV-1)-infected patients who maintain viral loads of <50 copies/ml. The mechanisms involved in this control of viral replication remain unclear. Prior studies suggested that these patients, as well as long-term nonprogressors, are infected with defective HIV-1 variants. Other reports have shown that the HLA-B*27 and -B*57 alleles are overrepresented in these patients, suggesting that host factors play a role in the control of viral replication. In order to distinguish between these hypotheses, we studied differences in viral isolates and immune responses of an HIV-1 transmission pair. While both patients are HLA-B*57 positive, the transmitter progressed to AIDS, whereas the recipient, who is also HLA-B*27 positive, is an ES. Isolates from both patients were replication competent and contained the T242N escape mutation in Gag, which is known to decrease viral fitness. While the acquisition of compensatory mutations occurred in isolates from the progressor, a superior HIV-specific CD8(+) T-cell response in the ES appears to have prevented viral replication and thus the evolution toward a more fit variant. In addition, CD8(+) T cells in the ES have selected for a rare mutation in an immunodominant HLA-B*27-restricted Gag epitope, which also has a negative impact on fitness. The results strongly suggest that through direct and indirect mechanisms, CD8(+) T cells in some ES control HIV-1 isolates are capable of causing profound immunosuppression.
Characteristic Analysis Of 1024-Point Quantized Radix-2 Fft/Ifft Processor (2012)

The precise analysis and accurate measurement of harmonic provides a reliable scientific industrial application. However, the high-performance DSP processor is the important method of electrical harmonic analysis. Hence, in this research work, the effort was taken to design a novel high-resolution single 1024-point fast Fourier transform (FFT) and inverse fast Fourier transform (IFFT) processors for improvement of the harmonic measurement techniques. Meanwhile, the project is started with design and simulation to demonstrate the benefit that is achieved by the proposed 1024-point FFT/IFFT processor. The pipelined structure is incorporated in order to enhance the system efficiency. As such, a pipelined architecture was proposed to statically scale the resolution of the processor to suite adequate trade-off constraints. The proposed FFT makes use of programmable fixed-point/floating-point to realize higher precision FFT.
An aromatic polyether in which sequence-randomization leads to induction of crystallinity: x-ray structure of the crystalline phase [-OArCOArArCOAr-]n (Ar = 1,4-phenylene) (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAn aromatic polyether in which sequence-randomization leads to induction of crystallinity: x-ray structure of the crystalline phase [-OArCOArArCOAr-]n (Ar = 1,4-phenylene)Howard M. Colquhoun, Christopher C. Dudman, David J. Blundell, Alan Bunn, Paul D. Mackenzie, P. Terence McGrail, Eric Nield, John B. Rose, and David J. WilliamsCite this: Macromolecules 1993, 26, 1, 107–111Publication Date (Print):January 1, 1993Publication History Published online1 May 2002Published inissue 1 January 1993https://pubs.acs.org/doi/10.1021/ma00053a016https://doi.org/10.1021/ma00053a016research-articleACS PublicationsRequest reuse permissionsArticle Views186Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A. Plé, o.p., Vie affective et chasteté. Collection « Lumière de la Foi », Paris, éditions du Cerf, 1964 (1967)

Klein Jean-Louis. A. Plé, o.p., Vie affective et chasteté. Collection « Lumière de la Foi », Paris, éditions du Cerf, 1964. In: Revue d'histoire et de philosophie religieuses, 47e année n°3,1967. p. 303.
High performance binary neural networks on the Xeon+FPGA™ platform (2017)

Convolutional neural networks (CNNs) are deployed in a wide range of image recognition, scene segmentation and object detection applications. Achieving state of the art accuracy in CNNs often results in large models and complex topologies that require significant compute resources to complete in a timely manner. Binarised neural networks (BNNs) have been proposed as an optimised variant of CNNs, which constrain the weights and activations to +1 or -1 and thus offer compact models and lower computational complexity per operation. This paper presents a high performance BNN accelerator on the Intel®Xeon+FPGA™ platform. The proposed accelerator is designed to take advantage of the Xeon+FPGA system in a way that a specialised FPGA architecture can be targeted for the most compute intensive parts of the BNN whilst other parts of the topology can be handled by the Xeon™ CPU. The implementation is evaluated by comparing the raw compute performance and energy efficiency for key layers in standard CNN topologies against an Nvidia Titan X Pascal GPU and other published FPGA BNN accelerators. The results show that our single-package integrated Arria™ 10 FPGA accelerator coupled with a high-end Xeon CPU can offer comparable performance and better energy efficiency than a high-end discrete Titan X GPU card. In addition, our solution delivers the best performance compared to previous BNN FPGA implementations.
Porcine pituitary dynorphin: complete amino acid sequence of the biologically active heptadecapeptide. (1981)

The full primary structure of the very potent opioid peptide dynorphin, from porcine pituitary, has been determined. It is (H)Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln(OH). The synthetic peptide with this sequence behaves identically to natural dynorphin in a number of ways, and it has the same potency in the guinea pig ileum myenteric plexus--longitudinal muscle bioassay. The potency is accounted for by the first 13 residues.
Nickel complexes with heterofunctionalized phosphine ligands. Catalytic oligomerization of ethylene with [Ni(C<sub>5</sub>Ph<sub>5</sub>){Ph<sub>2</sub>PCHC(O)Ph}] (1993)

Reaction of [Ni(C5Ph5)Br(CO)] with Ph2PCH2C(O)Ph in the presence of 1,8-bis(dimethylamino)naphthalene (proton sponge) gives the chelate complex [Ni(C5Ph5){Ph2PCHC(O)Ph}]1. The complexes [Ni(C5Ph5){Ph2PCHC(O)(C5H4)Fe(C5H5)}]2, [Ni(C5Ph5){Ph2PCHC(O)(1,3-C6H4)C(O)HCPPh2}Ni(C5Ph5)]3, [Ni(C5H5){Ph2PCHC(O)Ph}]4 and [Ni(C5H5){Ph2PCHC(O)(C5H4)Fe(C5H5)}]5 have been synthesised using the appropriate phosphine ligand and applying a procedure similar to that for 1. Complex 1, activated with NaBH4, exhibits catalytic activity in the low-pressure oligomerization of ethylene. At 130 °C, under 38 bar of ethylene, selectivities of up to 98% towards linear α-olefins were achieved. Protonation of the bimetallic complex 2 with HBF4 gave the cationic complex [Ni(C5Ph5){Ph2PCH2C(O)(C5H4)Fe(C5H5)}]BF46. Crystais of 6 belong to the orthorhombic space group Pbca with a= 19.427(6), b= 38.595(11), c= 13.001(4)Å and Z= 8. The structure was refined to R= 0.049 (R′= 0.067). The bonding of C5Ph5 contrasts with the bonding modes usually found for cyclopentadienyl ligands. The ring contains two short [1.384(8) and 1.389(8)], two medium [1.444(8) and 1.443(8)], and one long [1.474(8)Å] C–C bonds so that the C5Ph5 may be viewed as an (alkyl, diene) ligand. This unusual bonding is likely to result from the ‘chemical’ dissymmetry of the P,O ligand and the low trans influence of the oxygen atom. The extremely low ν, (CO) frequency of the co-ordinated ketone (1525 cm–1) reflects the strong electron-withdrawing effect of the Ni(C5Ph5)+ moiety.
FlexiBend (2015)

This paper presents FlexiBend, an easily installable shape-sensing strip that enables interactivity of multi-part, deformable fabrications. The flexible sensor strip is composed of a dense linear array of strain gauges, therefore it has shape sensing capability. After installation, FlexiBend can simultaneously sense user inputs in different parts of a fabrication or even capture the geometry of a deformable fabrication.
In Vitro and In Vivo Characterization of Recombinant Ebola Viruses Expressing Enhanced Green Fluorescent Protein (2007)

To facilitate an understanding of the molecular aspects of the pathogenesis of Zaire ebolavirus (ZEBOV) infection, we generated 2 different recombinant viruses expressing enhanced green fluorescent protein (eGFP) from additional transcription units inserted at different positions in the virus genome. These viruses showed in vitro phenotypes similar to that of wild-type ZEBOV (wt-ZEBOV) and were stable over multiple passages. Infection with one of the viruses expressing eGFP produced only mild disease in rhesus macaques, demonstrating a marked attenuation in this animal model. However, in mice lacking signal transducer and activator of transcription 1, both viruses expressing eGFP caused lethal cases of disease that were moderately attenuated, compared with that caused by wt-ZEBOV. In mice, viral replication could be easily tracked by the detection of eGFP-positive cells in tissues, by use of flow cytometry. These findings demonstrate that the incorporation of a foreign gene will attenuate ZEBOV in vivo but that these viruses still have potential for in vitro and in vivo research applications.
Diastereomerically and Enantiomerically Pure 2,3-Disubstituted Pyrrolidines from 2,3-Aziridin-1-ols Using a Sulfoxonium Ylide:  A One-Carbon Homologative Relay Ring Expansion (2007)

An ylide-based aza-Payne rearrangement of 2,3-aziridin-1-ols leads to an efficient process for the preparation of pyrrolidines. The aza-Payne rearrangement under basic reaction conditions favors the formation of epoxy amines. Subsequent nucleophilic attack of the epoxide by the ylide yields a bis-anion, which upon a 5-exo-tet ring-closure yields the desired pyrrolidine, thus completing the relay of the three-membered to the five-membered nitrogen-containing ring system. This process takes place with complete transfer of stereochemical fidelity and can be applied to sterically hindered aziridinols.
Statistical accuracy in the digital autocorrelation of photon counting fluctuations (1970)

Optical measurements by intensity fluctuation spectroscopy are subject to errors arising from the statistical nature of light and of the photo-detection process. The authors report the results of a calculation of the expected errors, due to these causes, in linewidth measurements by digital autocorrelation of photon counting fluctuations.
Nonlinear Feedback Control of a Dual-Cable Ropeway System (2010)

This paper investigates dynamic control of dual-cable transportation systems, where the haul cable drives a concentrated load on a flexible track cable. The objective of this research is to develop a nonlinear feedback control algorithm applied to this unique cable system, which can be applied to the Navy Underway Replenishment System. First, the nonlinear system model is developed which has the form of a second order nonlinear differential equation coupled with a set of algebraic constraints. Then a linearizing feedback control law is presented that drives a concentrated load smoothly from one point to another. The method is illustrated by simulation results.
Electrochemical Change of the Photonic Stop Band of the Ordered Macroporous WO3 Films (2002)

Abstract Three-dimensional macroporous tungsten trioxide (WO3) was electrochemically prepared by using the polystyrene opal as a template. The photonic stop band of the porous WO3 film could be changed when the WO3 was intercalated with lithium cation by the electrochemical method. The change of the stop band was attributed to the change of the refractive indices accompanied with the electrochromism of WO3.
Preparation and clinical application of immunomagnetic latex (2005)

Abstract Magnetic poly(methyl methacrylate) (PMMA)/poly(methyl methacrylate‐ co ‐methacrylic acid) [P(MMA–MAA)] composite polymer latices were synthesized by two‐stage soapless emulsion polymerization in the presence of magnetite (Fe 3 O 4 ) ferrofluids. Different types and concentrations of fatty acids were reacted with the Fe 3 O 4 particles, which were prepared by the coprecipitation of Fe(II) and Fe(III) salts to obtain stable Fe 3 O 4 ferrofluids. The Fe 3 O 4 /polymer particles were monodisperse, and the composite polymer particle size was approximately 100 nm. The morphology of the magnetic composite polymer latex particles was a core–shell structure. The core was PMMA encapsulating Fe 3 O 4 particles, and the shell was the P(MMA–MAA) copolymer. The carboxylic acid functional groups (COOH) of methacrylic acid (MAA) were mostly distributed on the surface of the composite polymer latex particles. Antibodies (anti‐human immunoglobulin G) were then chemically bound with COOH groups onto the surface of the magnetic core–shell composite latices through the medium of carbodiimide to form the antibody‐coated magnetic latices (magnetic immunolatices). The MAA shell composition of the composite latex could be adjusted to control the number of COOH groups and thus the number of antibody molecules on the magnetic composite latex particles. With a magnetic sorting device, the magnetic immunolatices derived from the magnetic PMMA/P(MMA–MAA) core–shell composite polymer latex performed well in cell‐separation experiments based on the antigen–antibody reaction. © 2005 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 43: 1342–1356, 2005
Platelet/polymorphonuclear leukocyte interaction in dynamic conditions: evidence of adhesion cascade and cross talk between P-selectin and the beta 2 integrin CD11b/CD18 (1996)

Adhesion between platelets and polymorphonuclear leukocytes (PMN) is a key event in thrombosis and inflammation. Double color fluorescence-activated cell sorter (FACS) analysis was used to determine the extent and kinetics of adhesion of thrombin-activated platelets to resting or activated PMN when mixed cell populations were incubated in dynamic conditions. Activated platelets bound very rapidly to PMN. Mixed cell conjugates reached a maximum at 1 minute and were reversible within 10 minutes. Platelet/PMN adhesion required both Ca2+ and Mg2+ and was markedly increased by the presence of Mn2+. The latter made mixed cell conjugates stable up to 10 minutes. Adhesion of platelets required metabolic activity of PMN and was abolished by tyrosine kinase inhibitors. Furthermore, adhesion of platelets to PMN resulted in binding of a monoclonal antibody (MoAb 24) known as beta 2 integrins "activation reporter." When PMN were activated by exogenous stimuli, the adhesion of platelets was markedly increased: fMLP induced a rapid and transient effect, while PMA resulted in a slower, but stable, increase in mixed conjugates formation. The hypothesis that activated PMN beta 2 integrins are able to bind a counter-receptor on platelets was directly demonstrated by the increase of mixed cell conjugates following PMN treatment with KIM127 and KIM185, two anti-CD18 antibodies able to induce the active conformation of beta 2 integrins. Consistently, two other anti-CD18, as well as an anti-CD11b inhibitory antibody abolished platelet/PMN adhesion. PMN beta 2 integrin activation was not the only mechanism for activated platelet/PMN adhesion to occur: indeed, this phenomenon could also be inhibited by two anti-P-selectin antibodies. Resting platelets did not adhere to resting PMN, but markedly adhered to fMLP- or PMA-activated PMN. Resting platelet/fMLP-activated PMN adhesion was abolished by anti-CD18 antibodies, but not by anti-P-selectin antibodies. In conclusion, activated platelet/PMN interaction can be modeled as an adhesion cascade involving a P-selectin-dependent recognition step and a functional signal. The latter proceeds through tyrosine kinase activation and enables a beta 2 integrin-dependent adhesion to a not yet identified counter-receptor constitutively expressed on platelet surface.
Cycloaddition reactions of nitrile sulfides with olefins (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCycloaddition reactions of nitrile sulfides with olefinsRobert K. Howe and John E. FranzCite this: J. Org. Chem. 1978, 43, 19, 3742–3745Publication Date (Print):September 1, 1978Publication History Published online1 May 2002Published inissue 1 September 1978https://pubs.acs.org/doi/10.1021/jo00413a025https://doi.org/10.1021/jo00413a025research-articleACS PublicationsRequest reuse permissionsArticle Views255Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Protocol-independent Content Negotiation Framework (1999)

A number of Internet application protocols have a need to provide
content negotiation for the resources with which they interact. MIME
media types [1,2] provide a standard method for handling one major
axis of variation, but resources also vary in ways which cannot be
expressed using currently available MIME headers. This draft sets out
terminology, an abstract framework and goals for protocol-independent
content negotiation, and identifies some technical issues which may
need to be addressed. The abstract framework does not attempt to
specify the content negotiation process, but gives an indication of
the anticipated scope and form of any such specification. The goals
set out the desired properties of a content negotiation mechanism.
Internet draft Protocol-independent content negotiation framework 25
March 1999
HBV DNA integration and HBV‐transcript expression in non‐B, non‐C hepatocellular carcinoma in Japan (2003)

Few studies have examined the etiology of hepatocellular carcinoma (HCC) in patients without hepatitis virus infection. We evaluated the role of occult hepatitis B virus (HBV) infection in the development of HCC in Japanese patients without hepatitis B surface antigen (HBsAg) and antibodies to hepatitis C antigen (anti-HCV). Twenty-one HBsAg negative and anti-HCV negative (non-B, non-C) patients with HCC were studied. HBV DNA in serum and HBV transcripts in liver were examined by polymerase chain reaction (PCR) or reverse transcription and PCR. HBV DNA integration was examined by Southern blot analysis or cassette-ligation-mediated PCR as described previously. p53 mutations were examined by direct sequencing. HBV DNA was not detected in serum from any patients. HBV-related transcripts were detected in 5 of 7 HCCs from patients with antibodies to hepatitis core antigen (anti-HBc) and in 3 of 14 HCCs from patients without anti-HBc (P = 0.0261). HBV DNA was integrated into human genome in two non-B, non-C HCCs. Of the 14 patients without anti-HBc, 5 had a history of excessive alcohol intake. In exons 5 through 8 of the p53 gene, mutations were detected in 2 of 8 HCCs with HBV-transcripts and in 5 of 13 HCCs without such transcripts. p53 mutation at codon 159 was found in 2 of 6 patients with excessive alcohol intake without HBV-transcripts. These results suggested that occult HBV infection might play an important role in hepatocarcinogenesis in non-B, non-C patients with anti-HBc and that excessive alcohol intake might be related to HCC in non-B, non-C patients in Japan.
CAPTURING AND MODELING COORDINATION KNOWLEDGE FOR MULTI-AGENT SYSTEMS (1996)

The agent view provides a level of abstraction at which we envisage computational systems carrying out cooperative work by interoperating globally across networks connecting people, organizations and machines. A major challenge in building such systems is coordinating the behavior of the individual agents to achieve the individual and shared goals of the participants. As part of a larger project targeted at developing an Agent Building Shell for multiagent applications, we have designed and implemented a coordination language aimed at explicitly representing, applying and capturing coordination knowledge for multiagent systems. The language provides KQML-based communication, an agent definition and execution environment, support for modeling interactions as multiple structured conversations among agents, rule-based approaches to conversation selection and execution, as well as an interactive tool for in context acquisition and debugging of cooperation knowledge. The paper presents these components in detail and then shows how the coordination language is used in the Agent Building Shell to manage content-based information distribution scenarios among agents and the coordination aspects of conflict management processes that occur when agents encounter inconsistencies. The major application of the system is the construction and integration of multiagent supply chain systems for manufacturing enterprises. This application is used throughout the paper to illustrate the introduced concepts and language constructs.
New Material for Permanent Magnets on a Base of Mn and Al (1960)

During an investigation of the Mn-Al system from 40–100% Mn, a new metastable phase was found,which has a tetragonal structure with lattice constants a = 2.77 A and c = 3.57 A and lattice positions 000 and 121212 with a preference of the Mn atoms for one of these positions. This τ phase, which has the approximate composition Mn1.11 Al0.89, can only be obtained by special heat treatment. It possesses remarkable magnetic properites. From the approach to saturation an anisotropy constant of about 107 ergs/cm3 can be calculated, while the extrapolated value σ∞ amounts to 96 erg/oe g; the latter corresponds to a 4πIs of 6200 G. Particles obtained by grinding the bulk material possess an HCI value of up to 6000 oe. No fixed correlation exists between particle size and the value of HCI; the latter is strongly dependent on the method of pulverization, and the authors are inclined to think that HCI is largely determined by the extent of deformation. The increase of HCI caused by grinding is accompanied by a decrease of the magnetic moment. This decrease can be partially reversed by aging. The observed decrease in the magnetic moment on pulverizing agrees with the value calculated from X-ray and neutron diffraction data. The current fine-particle theory is unable to give an adequate explanation of the HCI. An anisotropic permanent magnet was obtained by swaging cast bars, with the following properties in the preferred direction: Br = 4280 G, HCI = 4600 oe, HCB = 2750 oe, BHmax = 3.5×106 G oe.