gebhart/patrepeval huggingface dataset:
Totally implanted venous and arterial access system to replace external catheters in cancer treatment. (1982)

A totally implanted venous and arterial access system was tested in 30 cancer patients. The device, an injection port (Infuse-A-Port, Infusaid Corp., Sharon, Mass.), consisted of a 3.5 by 1.5 cm conical chamber with a self-sealing silicone rubber septum connected to a Silastic catheter. Ten patents had the injection port operatively placed for arterial access. A total of 39 bolus injections and 18 continuous infusions lasting an average 5.4 +/- 3.4 days were administered through the port. The total time of arterial access ranged from 70 to 370 days. No special program of heparinization was required to maintain patency. The injection port was used for central venous access in 20 patients. The first six patients had a small lumen catheter of 0.38 mm internal diameter, and five had occlusion between 142 and 447 days. Subsequently, 19 ports with a larger catheter lumen of 0.63 mm were used. These ports functioned for an average of 274 +/- 110 days (23 to 382 days). There were 380 single bolus injections and 64 continuous infusions. A variety of anticancer agents as well as whole blood, blood products, and antibiotics were administered with the device without difficulty. Patient acceptance was excellent.
Elevated plasma levels of glutamate in children with autism spectrum disorders (2016)

Excitatory neurotransmitter signaling through glutamate receptors modulates cognitive functions such as memory and learning, which are usually impaired in autism spectrum disorders (ASD). The aim of this study was to assess the clinical significance of plasma glutamate levels in ASD. Fifty-one children diagnosed with ASD, 51 typically developing children, and 51 children with intellectual disability matched for sex and age were assessed for plasma glutamate at admission. Plasma levels of glutamate were measured by liquid chromatography-tandem mass spectrometry and the severity of ASD was evaluated using the Childhood Autism Rating Scale Score. We found that the mean plasma glutamate levels were significantly (P<0.0001) higher in children with ASD compared with healthy controls and intellectual disability controls [36.1 (SD: 8.3) vs. 23.4 (4.2) vs. 24.7 (4.6) µM; P<0.001, respectively]. Levels of glutamate increased with increasing severity of ASD as defined by the Childhood Autism Rating Scale score. Receiver operating characteristics to diagnose ASD showed areas under the curve of glutamate of 0.92 [95% confidence interval (CI), 0.87-0.96], which was superior to high-sensitivity C-reactive protein [0.64 (95% CI, 0.55-0.75), P<0.001] and homocysteine (area under the curve, 0.72; 95% CI, 0.64-0.81; P<0.000). In multivariate logistic regression analysis, glutamate was an independent diagnosis indicator of ASD with an adjusted odds ratio of 1.362 (95% CI, 1.164-1.512; P<0.0001). The present study shows that autistic children had higher plasma levels of glutamate and elevated plasma glutamate levels may play an important role in the pathogenesis of autism. Further larger studies are required to support our findings.
Breeding for resistance to ear rot of maize, caused by <i>Stenocarpella maydis</i> (Berk) Sutton. 1. Evaluation of selection criteria (2002)

The objective of this study was to provide a better understanding of the interrelationship between methods of screening for resistance to ear rot, caused by Stenocarpella maydis. The inheritance of resistance as well as genetic and phenotypic correlation of various selection criteria were investigated. A complete diallel cross of 10 inbred lines, ranging from resistant to susceptible, was evaluated at each of three localities, representative of different environments within the South African maize production area. Plants were artificially inoculated twice during the vegetative stages of plant development. Resistance to ear rot was found to be controlled by additive gene effects, with low dominance and interaction effects. Significant genetic correlations existed between various characteristics relating to disease incidence, with high heritability and highly correlated responses. The incidence of rotted ears was the most practical and reliable method to select for resistance. However, the simultaneous use of some measurement of kernel infection was necessary to ensure detection of internal ear infection. An increase in the incidence of upright ears was indicated to result from S. maydis infection, rather than that upright ears predisposed ears to the disease.
Polymerization of Silicone Modified Acrylate Emulsion and Preparation of Self-Cleaning Exterior Wall Paint (2010)

Vinyl triethoxyl silicane, hydrogen silicone oil and microcrystal wax were separately used to modify the acrylic emulsion, wollastonite and synthesize the silicone wax emulsion for preparing exterior wall paint. The optimum conditions for the modifications and synthesis were experimentally presented. Under the optimum formula and operation conditions the silicone-modified acrylic emulsion exhibited good quality and all the property indexes of the exterior wall paint with a contact angle of about 140° were better than those regulated in the national standards issued by Chinese government. The structure of the modified acrylate emulsion, measured by infrared spectroscopy, was proved to be a real silicate-acrylate copolymerization emulsion.
The theory, design, and operation of the suppressed carrier data-aided tracking receiver (1973)

A viable, efficient, and easily mechanized carrier regenerating receiver for use in suppressed carrier-tracking system is described. The receiver referred to as a data-aided receiver (DAR) incorporates a data-aided loop (DAL) which provides the required carrier reference signal. The DAL employs the principle of decision feedback and as such is more efficient than other forms of suppressed carrier-tracking loops. The analysis, design, and implementation of the DAR are covered in detail. Performance comparisons and mechanization tradeoffs are made, wherever possible, with discrete carrier systems and other suppressed carrier systems presently in use. Experimental performance verification is given throughout in support of the theory presented.
Systematic development of a block copolymer adjuvant for trivalent influenza virus vaccine. (1998)

The current influenza virus vaccines induce systemic humoral immunity and short lived cellular immunity in young adults. Unfortunately these vaccines are only 50% efficacious in the elderly (> 65 years) and high risk groups of the very young. The use of a vaccine adjuvant to correct this deficit would therefore be very beneficial to these population groups. We have developed high molecular weight synthetic non-ionic block copolymers with adjuvant activity. These copolymers are compatible with, and active in, aqueous, physiological formulations in which they spontaneously assemble into 500-3000 nm particles. By varying both the molecular weight and the proportions of hydrophilic and hydrophobic components of the molecule, we have designed the optimal copolymer adjuvant for use with influenza hemagglutinin. This copolymer, termed CRL-1005, was investigated for its ability to augment the immune response of mice to the commercially-available human influenza vaccine, Fluogen. Co-formulation of CRL-1005 with the vaccine resulted in markedly increased antibody titres measured by both ELISA and the functional haemagglutination inhibition assay, indicating that critical immunogen epitopes were not destroyed. A single dose of copolymer and vaccine produced both long term rising antibody titres (six months) and primed for a potent secondary response. This high molecular weight copolymer is non-toxic and should therefore be well suited for widespread use.
<title>Development of a 2048 X 2048 imager for scientific applications</title> (1990)

A large-format CCD imager is described and tested. The CCD imager incorporates floating diffusion as well as floating gate amplifiers on a 2048 by 2048 format which was employed as the design base. The amplifiers are intended to allow repeated nondestructive read operations on individual pixels in the array. The serial register was separated into two independently clocked halves to permit simultaneous readout of all four quadrants of the imager. Extensive schematic layouts of the base model and modification are given. The results of a performance test are presented, showing good results in the cooling curve for average dark current, and for charge transfer characteristics. The amplifiers are intended to reduce net readout noise, and the simultaneous readout capability is intended to reduce total read time, although neither was fully tested. The large-format CCD imager is of interest for astronomical photography and spectroscopic applications.
MCH−/− Mice Are Resistant to Aging-Associated Increases in Body Weight and Insulin Resistance (2006)

Ablation of the hypothalamic peptide, melanin-concentrating hormone (MCH), leads to a lean phenotype and resistance to diet-induced obesity. Observation of MCH(-/-) mice at older ages suggested that these effects persist in mice >1 year old. Leanness secondary to caloric restriction is known to be associated with improved glucose tolerance as well as an overall increase in life span. Because the MCH(-/-) model represents leanness secondary to increased energy expenditure rather than caloric restriction, we were interested in determining whether this model of leanness would be associated with beneficial metabolic effects at older ages. To assess the effects of MCH ablation over a more prolonged period, we monitored male and female MCH(-/-) mice up to 19 months. The lean phenotype of MCH(-/-) mice persisted over the duration of the study. At 19 months, MCH(-/-) male and female mice weighed 23.4 and 30.8% less than their wild-type counterparts, a result of reduced fat mass in MCH(-/-) mice. Aged MCH(-/-) mice exhibited better glucose tolerance and were more insulin sensitive compared with wild-type controls. Aging-associated decreases in locomotor activity were also attenuated in MCH(-/-) mice. We also evaluated two molecules implicated in the pathophysiology of aging, p53 and silent inflammatory regulator 2 (Sir2). We found that expression of the tumor suppressor protein p53 was higher in MCH(-/-) mice at 9 and 19 months of age. In contrast, expression of Sir2 was unchanged. In aggregate, these findings suggest that MCH ablation improves the long-term outcome for several indicators of the aging process.
Blowspinning: A New Choice for Nanofibers (2020)

Blowspinning is a new technique that enables the large-scale production of fibers with diameters ranging from micrometer to nanometer, which is more like a combination of melt-blown and electrospinning but has its own characteristics. This method can be used to deposit fibers in situ and produce various fibrous materials, such as coating, nonwoven, and sponge. These characteristics provide a new strategy for nanofiber application and attract the interest of many researchers. Regarding the blowspinning technique, systematic research had been carried out, involving basic principles, empirical studies, spinning equipment, and application. This review is intended to emphasize trends and gaps in the form of a concise illustration of various research directions.
관동맥 질환에서 혈청 Troponin T의 임상적 의의 (1994)

Objectives: Although the diagnosis of coronary heart disease is usually straight forward, conventional diagnostic tests, such as CK, CK-MR, LDH, and AST have several drawbacks. The diagnostic efficiency of these conventional thests is disappointingly low, especially in minimal myocardial damage. l herefore, there has be necessity of more sensitive and specific diagnostic thest. Recently, cardiac TnT (TnT) was introduced with better sensitivity, specificity, and more wide diagnostic window. So we analyzed distribution of TnT in control, release kinetics, diagnositic significance of TnT in coronary heart disease including unstable angina and acute myocardial infarction, and efficiency of TnT as a marker of reperfusion in acute myocardial infarction. Methods: We tested cardiac TnT in 40 normal healthy subjects and 25 extracardiac traumatic patients as control group. We also tested cardiac TnT in 34 patients with acute myocardial infarction and 27 patients with unstable angina. We evaluated the distribution and serial change of cardiac TnT with other cardiac enxzymes after chest pain onset, the discriminant power of Tnl in discriminating of reperfusion after thrombolytic therapy in patients with acute myocardial infarction with conventional coronary angiography and the correlation between release kinetics of TnT and left ventricular ejection fraction with echocaroliography. Results: 1) In control group, all 65 cases serum TnT value were less than 0.2㎍/L. And its specificity (100%) and sensitivity in diagnosis of coronary heart disease including untable angina(acute myocardial infarction: 100%, unstable angina 70.4%) was better than those of other cardiac enzymes, such as CK, CK-MB. 2) In patient group, the release pattern of cardiac TnT was in bimodal curve pattern, while the pattern of other cardiac enzymes was in unimodal pattern. 3) In acute myocardial infarction, the first peak value of cardiac TnT appeared siginificantly earlier (9.53±2.36 hr in stable-reperfused group, 13.40±1.92 hr in non-reperfused group of acute MI than that of caridac enzymes; CK(17.65±6.48 hr in stable-reperfused group 27.53±10.26 hr in non-reperfused group), and CK-MH (16.84±7.93hr in stable-reperfused group, 24.33±10.36 hr in non-reperfused group of acute MI)(p 0.6, p< 0.001). Conclusion: Cardiac troponin T was a good diagnostic marker for coronary heart disease including unstable angina and acute myocardial infarction with better sensitivity and specificity, for discriminating of reperfusion after thrombolytic therapy, and for the prognosis of remnant left ventricular global systolic function
Analyzing peer-to-peer traffic across large networks (2002)

The use of peer-to-peer (P2P) applications is growing dramaticaliy, particularly for sharing large video/audio files and software. In this paper, we analyze P2P traffic by measuring flow-level information collected at multiple border routers across a large ISP network, and report our investigation of three popular P2P systems -- FastTrack, Gnutella, and DirectConnect. We characterize the P2P traffic observed at a single ISP and its impact on the underlying network. We observe very skewed distribution in the traffic across the network at different levels of spatial aggregation (IP, prefix, AS). All three P2P systems exhibit significant dynamics at short times scale and particularly at the IP address level Still, the fraction of P2P traffic contributed by each prefix is much more stable than the corresponding distribution of either Web traffic or overall traffic. The high volume and good stability properties of P2P traffic indicates that the P2P workload is a good candidate for being managed via application-specific layer-3 traffic engineering in an ISP's network.
Sentiment analysis using machine learning (2015)

In recent years, social media and TV-production has formed a strong link between each other. The most popular social media platform in TV-industry is Twitter, where over a million tweets are shared in one day. Tweet content is feedback straight from the viewers, and might include more valuable information than individual surveys. Going through millions of tweets is hard or impossible manually. This thesis studies, how to teach a machine by supervised manner to analyze tweets. Machine analyzes sentiments based on the features that tweets include. \n\nThe main goal of this thesis is to clarify how the content can be received, prepared, extracted and classified. The study indicates that sentiments can be caught from Twitter data using mathematical patterns. \n\nThe thesis is divided into 5 chapters. Chapter 1 is the introduction for the sentiment analyzing with machine learning capabilities. Chapter 2 is the literature study part, where elements and techniques are explored. Chapter 3 is the implementation part, where selected classification methods and techniques for text data are specified. Chapter 4 covers results and chapter 5 finishes the work with conclusions.
Synthesis and Biological Evaluation of Some Furanones as Putative Chitinase Inhibitors (2005)

Analogs of naturally occurring furanones that were reported to be weak inhibitors of Serratia marcescens chitinases were prepared and tested towards various chitinases. Some of these compounds - but not the natural products - were found to be weak but selective inhibitors; all glycosylated analogs tested were inactive. Activation of the plant enzyme hevamine was observed in one case, which is unusual.
A novel non-data-aided symbol timing recovery technique for OFDM systems (2006)

A new highly efficient non-data-aided technique to recover symbol timing of orthogonal frequency-division multiplexing systems is proposed. The algorithm in the proposed work exploits the interference that results due to the loss of orthogonality between subcarriers, where the second-order statistics of the resulting interference is proportional to the offset from the optimum sampling point. The presented technique does not require prior fine carrier synchronization, and it is capable of extracting symbol timing at low E/sub s//N/sub 0/ values with large carrier frequency offsets (CFOs). The system performance was investigated in multipath fading channels with large CFOs and additive white Gaussian noise.
Plant cell cultures as a model for the biochemistry of crop selectivity (1999)

Plant cell cultures have been used to study the metabolic degradation of 4-amino-5-methyl-2-(tert-butylaminocarbonyl)-1,2,4-triazolin-3-one. The biochemical basis of selectivity was shown to reside in effective metabolic conjugation. The herbicide was eliminated from cell cultures of beet (which is tolerant to it) by conjugation (N-glycolisation), but this occured to only a limited extent with cell cultures of non-target plants such as soybean.
Improvement of Coffee Aroma by Removal of Pungent Volatiles Using A‐Type Zeolite (1996)

ABSTRACT Experimental studies were conducted using molecular sieve zeolites to remove pungent smell components from a coffee aroma‐containing gas evolved from roasted and ground coffee packed in a percolation vessel. The components such as methyl mercaptan or acetaldehyde were selectively adsorbed from coffee volatiles, and a decrease of pungent odor was recognized on sensory evaluation. The adsorption selectivity was based on pore sizes of adsorbents and molecular sizes of adsorbates. Zeolite 5Å was preferable to 4Å for separation efficiency of methyl mercaptan and recovery yield of residual volatile compounds.
Labyrinth Seal Leakage Equation (2010)

A seal is a component used in a turbomachine to reduce internal leakage of the working fluid and to increase the machine's efficiency. The stability of a turbomachine partially depends upon the rotodynamic coefficients of the seal. The integral control volume based rotodynamic coefficient prediction programs are no more accurate than the accuracy of the leakage mass flow rate estimation. Thus an accurate prediction of the mass flow rate through seals is extremely important, especially for rotodynamic analysis of turbomachinery.\nFor labyrinth seals, which are widely used, the energy dissipation is achieved by a series of constrictions and cavities. When the fluid flows through the constriction (under each tooth), a part of the pressure head is converted into kinetic energy, which is dissipated through small scale turbulence-viscosity interaction in the cavity that follows. Therefore, a leakage flow rate prediction equation can be developed by comparing the seal to a series of orifices and cavities. Using this analogy, the mass flow rate is modeled as a function of the flow coefficient under each tooth and the carry over coefficient, which accounts for the turbulent dissipation of kinetic energy in a cavity. This work, based upon FLUENT CFD simulations, initially studies the influence of flow parameters, in addition to geometry, on the carry over coefficient of a cavity, developing a better model for the same. It is found that the Reynolds number and clearance to pitch ratios have a major influence and tooth width has a secondary influence on the carry over coefficient and models for the same were developed for a generic rectangular tooth on stator labyrinth seal.\nThe discharge coefficient of the labyrinth seal tooth (with the preceding cavity) was found to be a function of the discharge coefficient of a single tooth (with no preceding cavity) and the carry over coefficient. The discharge coefficient of a single tooth is established as a function of the Reynolds number and width to clearance ratio of the tooth and a model for the same is developed. It is also verified that this model describes the discharge coefficient of the first tooth in the labyrinth seal. By comparing the coefficients of discharge of compressible flow to that of incompressible flow at the same Reynolds number, the expansion factor was found to depend only upon the pressure ratio and ratio of specific heats. A model for the same was developed. Thus using the developed models, it is possible to compute the leakage mass flow rate as well as the axial distribution of cavity pressure across the seal for known inlet and exit pressures. The model is validated against prior experimental data.
Wafer-level integration of on-chip antennas and RF passives using high-resistivity polysilicon substrate technology (2004)

High-resistivity polycrystalline silicon (HRPS) wafers are utilized as low-loss substrates for three-dimensional integration of on-chip antennas and RF passive components (e.g. large inductors) in wafer-level chip-scale packages (WLCSP). Sandwiching of HRPS and silicon wafers enables to integrate large RF passives with a spacing of >150 /spl mu/m to the conductive silicon substrate containing the circuitry, while providing mechanical stability, reducing form factor and avoiding any additional RF loss. Antenna performance comparable to glass substrates and high quality factors for large spiral inductors (Q=11 at 1 GHz; 34 nH) are demonstrated. The HRPS substrates have high dielectric constant, low RF loss, high thermal conductivity, perfect thermal matching, and processing similar to single-crystalline silicon.
Attenuation correction in PET using single photon transmission measurement (1994)

The use of single photon transmission measurement with a rotating rod source has been evaluated to measure the attenuation correction factors in positron emission tomography (PET). The singles projections are resampled into the coincidence geometry using the detector positions and the rod source location. A nonparalyzable dead time correction algorithm was developed for the block detectors used in the McMaster PET scanner. This enables accurate attenuation correction factors (ACFs) to be computed using a wide range of source strengths for transmission scanning. Transaxial resolution is approximately 6 mm, which is comparable to emission scanning performance. Axial resolution is about 25 mm, with only crude source collimation. ACFs are underestimated by as much as 10% due to increased cross-plane scatter, compared to coincidence transmission accuracy. The response of the correction factors to object density is within 15%, when comparing singles transmission measurement to current coincidence transmission measurement. The major advantage of using singles transmission measurement is a dramatically increased count rate. A factor of 7 increase in count rate over coincidence scanning is possible with a 2-mCi transmission rod source. Uniformity of 2% in the transmission images is possible with this source strength and a 2-min acquisition. There are no randoms counted in singles transmission scans, which makes the measured count rate vary linearly with source activity. Singles detector dead time losses are approximately 6% in the detectors opposite a 2-mCi rod source.