gebhart/patrepeval huggingface dataset:
MVC model, struts framework and file upload issues in web applications based on J2EE platform (2004)

This paper describes the web application based on the J2EE platform indicating the MVC model, Struts framework and file upload issues. The development of\ninternet technology and the will to standardize the mechanisms used in implementation of internet applications was the basis background for the development of J2EE platform.\nThe project of International Office TUL internet service is an application based on the above mentioned environment. The specification of the project is closely connected with the activities and needs of the staff of the International Office. The article presents the use of MVC model on J2EE platform on an example of open source Apache/Tomcat application server and the database management system MySql.
Carcinogenesis associated with parasites other than Schistosoma, Opisthorchis and Clonorchis: A systematic review (2016)

Only three helminths (Schistosoma haematobium, Opisthorchis viverrini and Clonorchis sinensis) are directly associated with carcinogenesis in humans whereas the role of other parasites in cancer remains unclear. This study aimed to perform a systematic review to identify recent insights in the role of other parasite infections in carcinogenesis. We conducted systematic searches of MEDLINE and EMBASE on July 2015. Our primary outcome was the association between parasitic infections and carcinogenesis. Out of 1,266 studies, 19 were selected for detailed evaluation (eight for helminths and 11 for protozoa). The mechanisms of helminth-induced cancer included chronic inflammation, sustained proliferation, modulation of the host immune system, reprogramming of glucose metabolism and redox signaling, induction of genomic instability and destabilization of suppressor tumor proteins, stimulation of angiogenesis, resisting cell death, and activation of invasion and metastasis. In addition to the current knowledge, the following parasites were found in cancers or tumors: Echinococcus, Strongyloides, Fasciola, Heterakis, Platynosomum and Trichuris. Additional parasites were found in this systematic review that could potentially be associated with cancers or tumors but further evidence is needed to elaborate a cause-effect relationship.
Polyquaternium-mediated delivery of morpholino oligonucleotides for exon-skipping <i>in vitro</i> and in <i>mdx</i> mice (2017)

Antisense oligonucleotide therapy for Duchenne muscular dystrophy has shown great potential in preclinical and clinical trials, but its therapeutic applications are still limited due to inefficient delivery. In this study, we investigated a few polyquaterniums (PQs) with different size and composition for their potential to improve delivery performance of an antisense phosphorodiamidate morpholino oligomer (PMO) both in vitro and in vivo. The results showed that Luviquat<sup>TM</sup> series, especially PQ-1 and PQ-3, promoted the exon-skipping efficiency comparable to Endoporter-mediated PMO delivery in vitro. Significant enhancement in skipping dystrophin exon 23 has also been achieved with PQ-3 up to seven-fold when compared to PMO alone in mdx mice. Cytotoxicity of the PQs was lower than Endoporter and PEI 25 K in vitro and muscle damage not clearly detected in vivo under the tested concentrations. These results together demonstrate that the optimization of PQ in molecular size, composition and distribution of positive charges is the key factor to achieve enhanced PMO exon-skipping efficiency. The higher efficiency and lower toxicity endow polyquaternium series as AO delivery enhancing agents for treating muscular dystrophy and other diseases.
Silicon RF MEMS Based Optical Modulator (2010)

This paper reports on the co-fabrication of photonic whispering gallery mode disk resonators and RF MEMS radial contour mode resonators on the same SOI substrate. By mechanically coupling the MEMS and photonic resonators, we have demonstrated a silicon RF MEMS based optical modulator which can modulate light with wavelength 1560 nm at 288 MHz.
Tackling class imbalance with ranking (2016)

In classification, when there is a disproportion in the number of observations in each class, the data is said to be class imbalance. Class imbalance is pervasive in real world applications of data classification and has been the focus of much research. The minority class contributes too little to the decision boundary because the learning process learns from each observation in isolation. In this paper, we discuss the application of learning pairwise rankers as a solution to class imbalance. We compare ranking models to alternatives from the literature.
Effect of salts on dynamics of water: A Raman spectroscopy study (1990)

In this work, we have studied, by means of Raman spectroscopy, water-additives interactions in the case of alkaline halogenides aqueous solutions. We have obtained some parameters describing the evolution of water structure vs concentration or the nature of the added salts. These parameters show, as previously described, a more important effect of anions than cations. Next, the evolution of the dynamical properties of the solution depends on the size of the ions. Moreover, the development of a new band in the isotropic part of the salts solutions spectra is attributed to water–ions interactions involved in the dynamics of hydration shells.
Generation of allenyliodinanes and their reductive iodonio-Claisen rearrangement (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGeneration of allenyliodinanes and their reductive iodonio-Claisen rearrangementMasahito Ochiai, Takao Ito, Yoshikazu Takaoka, and Yukio MasakiCite this: J. Am. Chem. Soc. 1991, 113, 4, 1319–1323Publication Date (Print):February 1, 1991Publication History Published online1 May 2002Published inissue 1 February 1991https://pubs.acs.org/doi/10.1021/ja00004a037https://doi.org/10.1021/ja00004a037research-articleACS PublicationsRequest reuse permissionsArticle Views1221Altmetric-Citations81LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A chemical reaction heat pump system adopting the reactive distillation process (2002)

A new configuration of the chemical reaction heat pump system using 2-propanol dehydrogenation and acetone hydrogenation reactions was proposed in this study. To overcome the intrinsic thermodynamic limitation of chemical reaction heat pump systems, the reactive distillation process was adopted. Through the experimental study, the new configuration showed the better performance compared to previous ones. This study revealed a new design possibility of the thermodynamically efficient and economically chemical reaction heat pump system.
Tryptophan mutants in Arabidopsis: the consequences of duplicated tryptophan synthase beta genes. (1991)

The cruciferous plant Arabidopsis thaliana has two closely related, nonallelic tryptophan synthase beta genes (TSB1 and TSB2), each containing four introns and a chloroplast leader sequence. Both genes are transcribed, although TSB1 produces greater than 90% of tryptophan synthase beta mRNA in leaf tissue. A tryptophan-requiring mutant, trp2-1, has been identified that has about 10% of the wild-type tryptophan synthase beta activity. The trp2-1 mutation is complemented by the TSB1 transgene and is linked genetically to a polymorphism in the TSB1 gene, strongly suggesting that trp2-1 is a mutation in TSB1. The trp2-1 mutants are conditional: they require tryptophan for growth under standard illumination but not under very low light conditions. Presumably, under low light the poorly expressed gene, TSB2, is capable of supporting growth. Genetic redundancy may be common to many aromatic amino acid biosynthetic enzymes in plants because mutants defective in two other genes (TRP1 and TRP3) also exhibit a conditional tryptophan auxotrophy. The existence of two tryptophan pathways has important consequences for tissue-specific regulation of amino acid and secondary metabolite biosynthesis.
Combined methods to extend the lifetime of power hungry WSN with multimodal sensors and nanopower wakeups (2012)

During recent years, there has been a growing interest on wireless sensor networks (WSNs) and on the opportunities opened by this technology. Since the energy consumption is a bottleneck in WSNs, reducing it has a significant impact on the applicability of this technology. Typically, the energy consumed by wireless communication and by power-hungry sensors as CMOS imagers or Gas sensors, is dominant over the power required for computation or other activities of the node. Hence, an efficient management of the resources leading to a reduction of unnecessary communication and minimizing the use of power-hungry sensor while keeping the same performance is desirable to extend the life-time of the network. In this paper we address the challenges of exploiting wake-up receivers and heterogeneous sensors in WSN applications to reduce the average power consumption of individual nodes. In particular, we show how to configure a WSN which includes Pyroelectric InfraRed (PIR) sensors, smart camera sensors and a nano-Watt wake up radio as secondary radio receiver to efficiently extend the autonomy of the system. The evaluation of the proposed approach shows a significant reduction of the activity of the primary radio and of the high power sensor while keeping the same accuracy. We prototyped and tested the nodes, and used their characterization to demonstrate through simulations the power consumption reduction and the life-time extension of the network in a typical surveillance application.
Increased uridine kinase (ATP: uridine 5'-phosphotransferase; EC 2.7.1.48) activity in human and rat tumors. (1998)

The activity of uridine kinase (ATP: uridine 5'-phosphotransferase; EC 2.7.1.48), the rate-limiting enzyme of the UMP salvage pathway, was measured in human ovaries and ovarian carcinomas, in a spectrum of six rat hepatomas of different growth rates and in eleven normal rat tissues of high and low cell renewal rates. In a standard isotopic method developed for the 100,000 x g fraction, uridine kinase activity was linear for 20 min and proportional with protein concentration over a range of 0.1 to 0.8 mg per 0.1 ml reaction mixture. The apparent Kms for uridine, ATP and Mg++ in normal rat liver were 5.0, 3.4 and 1.5 mM and in the rapidly growing hepatoma 3924A, 0.8, 2.1 and 1.1 mM, respectively. In normal control ACl/N and Buffalo strain rat livers, kinase activity ranged from 159 to 180 nmol/h/mg protein. In hepatomas of slow and intermediate growth rates, kinase activity increased to 1.5- to 2.6-fold, and in hepatomas of rapid growth rates, to 5.1- to 5.8-fold over that of the relevant control, normal livers. When hepatoma 3924A tissue culture cells were plated and expressed their proliferative program, kinase activity increased to 2.1-fold in early log phase. To further clarify the linkage between uridine kinase and cell replicating capacity, the enzyme activity was measured in rat organs of high and low cell renewal. The kinase activity in liver of adult male Wistar rats was 176 +/- 6 nmol/h/mg protein. Activities in thymus, spleen and bone marrow were 4.7-, 2.1-, and 1.8-fold, respectively, of rat liver values; in adipose tissue, the activities were low. The decay rates of uridine kinase were examined in rats injected with a high dose of cycloheximide, which inhibits protein biosynthesis by 90%. The t(1/2) of the kinase in rat bone marrow was 0.64 h, in rat liver longer than 6 h. In human ovary and ovarian carcinoma, the apparent Kms for uridine were 11.5 and 0.5 mM, respectively. In human ovary (n = 3), kinase activity was 38 nmol/hr/mg protein; in ovarian carcinoma (n = 6), the activity increased to 5- to 13-fold over that in ovary. The positive linkage of uridine kinase activity with proliferation and transformation is apparent in human ovarian carcinomas and in rat hepatomas of different growth rates. Therefore, the increased uridine kinase activity should be an interesting target for anticancer chemotherapy.
Assessment of Vasculature of Meningiomas and the Effects of Embolization with Intra-arterial MR Perfusion Imaging: A Feasibility Study (2007)

MR perfusion imaging with selective IA injection of dilute contrast can reveal the distribution territory of vessels. Changes in tumor vasculature could be detected after embolization, which reveal the volumetric fraction of the tumor affected by the therapy.
Acute and chronic suppression of leukotriene B<sub>4</sub> synthesis EX vivo in neutrophils from patients with rheumatoid arthritis beginning treatment with methotrexate (1992)

The significant decreases in the formation of omega-oxidation products of LTB4 and in the total generation of neutrophil 5-LO pathway products in the absence of a significant change in the release of 3H-arachidonic acid or the generation of platelet-activating factor suggest that the activity of the 5-LO enzyme in neutrophils is inhibited. We conclude that weekly oral MTX therapy in patients with active RA inhibits neutrophil 5-LO pathway product generation in a pattern consistent with inhibition of the activity of the 5-LO enzyme; an effect is observed after the first dose. The inhibition of 5-LO is cell-selective and cumulative, with a superimposed incremental inhibition observed after the weekly MTX dose.
Enhancing Oil Recovery of Low-Permeability Berea Sandstone through Optimized Nanofluids Concentration (2013)

Abstract Current global demand for fossil fuel such as oil is still high. This encourages oil and gas industries to improve their effort of finding new discoveries, developing technique and maximizing recovery of their current resources including in low-permeability reservoir. Enhanced oil recovery (EOR) is a technique to enhanced ultimate recovery. Since technology has been continuously developed such as nanotechnology/nano-size material, EOR methods have improved. One of them is Nano-EOR that triggered great attention in last decade. Nanoparticles may alter the reservoir fluid composition and rock-fluid properties to assist in mobilizing trapped oil. Most of observation from lab-scale reported that it seems potentially interesting for EOR. Since reservoir management is very essential for the success of all improved/enhanced oil recovery (IOR/EOR) methods, optimizing nanofluids concentration is a proposed reservoir management to maximize oil recovery using Nano-EOR in this paper. Low-permeability water-wet Berea sandstones core-plugs with porosity ranged 13-15% and permeability ranged 5-20 mD were tested. A hydrophilic silica nanoparticles with primary particle size 7 nm was employed without surface treatment. Nanofluids with various concentration ranged 0.01 - 0.1 wt.% were synthesized with synthetic saline water for optimizing study. The wettability alteration due to nanofluids was observed; coreflood experiment was conducted and compared its displacement efficiency. The results observed a range of nanofluids concentration that could maximize oil recovery in low-permeability water-wet Berea sandstone. Although contact angle of aqueous phase decreases as nanofluids concentration increase which means easier of oil to be released but we observed that higher concentration (e.g. 0.1 wt.%) has a tendency to block pore network and will decrease or even without additional oil recovery. This study provides if concentration of nanofluids has an important parameter in Nano-EOR and could be optimized to maximize oil recovery of low-permeability water-wet Berea sandstone.
Spatially Compact MR-Guided Kernel EM for PET Image Reconstruction (2018)

Positron emission tomography (PET) is a highly sensitive functional and molecular imaging modality which can measure picomolar concentrations of an injected radionuclide. However, the physical sensitivity of PET is limited, and reducing the injected dose leads to low count data and noisy reconstructed images. A highly effective way of reducing noise is to reparameterise the reconstruction in terms of MR-derived spatial basis functions. Spatial basis functions derived using the kernel method have demonstrated excellent noise reduction properties and maintain shared PET-MR detailed structures. However, as previously shown in the literature, the MR-guided kernel method may lead to excessive smoothing of structures that are only present in the PET data. This work makes two main contributions in order to address this problem: first, we exploit the potential of the MR-guided kernel method to form more spatially-compact basis functions which are able to preserve PET-unique structures, and secondly, we consider reconstruction at the native MR resolution. The former contribution notably improves the recovery of structures which are unique to the PET data. These adaptations of the kernel method were compared to the conventional implementation of the MR-guided kernel method and also to MLEM, in terms of ability to recover PET unique structures for both simulated and real data. The spatially-compact kernel method showed clear visual and quantitative improvements in the reconstruction of the PET unique structures, relative to the conventional kernel method for all sizes of PET unique structures investigated, whilst maintaining to a large extent the impressive noise mitigating and detail preserving properties of the conventional MR-guided kernel method. We therefore conclude that a spatially-compact parameterisation of the MR-guided kernel method, should be the preferred implementation strategy in order to obviate unnecessary losses in PET-unique details.
Data Cache Prefetching Using a Global History Buffer (2005)

A new structure for implementing data cache prefetching is proposed and analyzed via simulation. The structure is based on a Global History Buffer that holds the most recent miss addresses in FIFO order. Linked lists within this global history buffer connect addresses that have some common property, e.g. they were all generated by the same load instruction. The Global History Buffer can be used for implementing a number of previously proposed prefetch methods, as well as new ones. Prefetching with the Global History Buffer has two significant advantages over conventional table prefetching methods. First, the use of a FIFO history buffer can improve the accuracy of correlation prefetching by eliminating stale data from the table. Second, the Global History Buffer contains a more complete (and intact) picture of cache miss history, creating opportunities to design more effective prefetching methods. Global History Buffer prefetching can increase correlation prefetching performance by 20% and cut its memory traffic by 90%. Furthermore, the Global History Buffer can make correlations within a load’s address stream, which can increase stride prefetching performance by 6%. Collectively, the Global History Buffer prefetching methods perform as well or better than the conventional prefetching methods studied on 14 of 15 benchmarks.
Distance learning in academic health education (2001)

Distance learning is an apparent alternative to traditional methods in education of health care professionals. Non-interactive distance learning, interactive courses and virtual learning environments exist as three different generations in distance learning, each with unique methodologies, strengths and potential. Different methodologies have been recommended for distance learning, varying from a didactic approach to a problem-based learning procedure. Accreditation, teamwork and personal contact between the tutors and the students during a course provided by distance learning are recommended as motivating factors in order to enhance the effectiveness of the learning. Numerous assessment methods for distance learning courses have been proposed. However, few studies report adequate tests for the effectiveness of the distance-learning environment. Available information indicates that distance learning may significantly decrease the cost of academic health education at all levels. Furthermore, such courses can provide education to students and professionals not accessible by traditional methods. Distance learning applications still lack the support of a solid theoretical framework and are only evaluated to a limited extent. Cases reported so far tend to present enthusiastic results, while more carefully-controlled studies suggest a cautious attitude towards distance learning. There is a vital need for research evidence to identify the factors of importance and variables involved in distance learning. The effectiveness of distance learning courses, especially in relation to traditional teaching methods, must therefore be further investigated.
Synthesis, characterization, and stability of poly[(alkylene oxide) ester] thermoplastic elastomers (1997)

Poly(ether ester) block copolymers were prepared using a transesterification/polycondensation bulk synthesis with systematic control of the terephthalic acid/butane-diol aromatic diester block (`hard segment') and with poly(tetramethylene oxide) [PTMO], poly(hexamethylene oxide) [PHMO], or poly(decamethylene oxide) [PDMO] poly(alkylene oxide) soft segments. The respective number average molecular weights were 980, 930, and 940 Da. A series of the poly(ether ester)s with hard segment fractions of 25, 29, 37, and 51% were prepared. One example of the PDMO polyester was prepared at a 51% hard segment fraction. The polyesters were characterized using viscometry, gel permeation chromatography, 1H-NMR spectroscopy, differential scanning calorimetry, and tensile testing. The novel poly(ether ester)s, the PTMO polyester, and the commercial control, Hytrel® 4056, were compared for their resistance to degradation in a 50% aqueous hydrogen peroxide solution at 37°C, boiling water buffered at pH 1 and 13, an oxygen stream at 200°C, and a nitrogen stream at 200°C. The Hytrel® 4056 and the PTMO polyesters fragmented in hydrogen peroxide within 24 h while the PHMO and PDMO polyesters were much less degraded. Resistance to hydrolytic and thermal degradation increased as the ratio of aliphatic methylene to ether increased: PTMO < PHMO < PDMO. Samples containing higher hard segment fractions demonstrated improved resistance to hydrolysis. © 1997 John Wiley & Sons, Inc. J Appl Polym Sci 65:1319–1332, 1997
Clinical use of microvascular PTFE grafts (1995)

This paper reports on the first clinical case where a polytetrafluoroethylene (PTFE) graft of less than 3 mm in diameter was implanted in the arterial system of a patient to bridge a vascular defect. A 1.5 cm long, 1.5 mm diameter prosthesis was interposed in the superficial palmar arch of a man who sustained a laceration of the palm of his dominant hand. The graft was implanted by means of the 3M Precise Microvascular Anastomotic System on one end, and by conventional microsurgical technique on the other end. There were no postoperative complications. The patient resumed his pre-injury activities 9 weeks after trauma. Serial Doppler ultrasound examinations showed normal blood flow and complete patency of the graft. An angiogram performed 12 weeks postoperatively confirmed the patency of the prosthesis. Twelve months post-operatively the patient is free from complications. The use of small diameter PTFE prostheses may be considered when planning grafting procedures for microvascular defects.