gebhart/patrepeval huggingface dataset:
A Review of Reality-Based 3D Model Generation, Segmentation and Web-Based Visualization Methods (2012)

The tremendous improvements in data capturing technologies and in the related processing methodologies are opening more and more possibilities in different fields of applications. In particular the Cultural Heritage field is taking great advantages from the latest reality-based 3D modelling developments. One of the most significant consequences of the introduction of digital 3D modelling in the heritage field is the great opportunity of using 3D models as highly effective and intuitive means of communication or as interfaces to share and visualize information collected e.g. in databases. Unstructured 3D data recorded with photogrammetry or laser scanning techniques are generally converted in polygonal textured 3D models, subdivided and organized using automated and manual methods and finally visualized using web-based tools in order to allow remote access and data retrieval to a wider range of users, with evident advantages in enlarging knowledge and education. The paper presents the state-of-the-art in 3D surveying and modelling, segmentation and web-based access for heritage sites and objects (Fig. 1). The most reliable and practical approaches are presented with references and best practices. Some future perspectives are also addressed.
The Modified<i>r</i>Out of<i>m</i>Control Chart (2008)

It is well known that the Shewhart control chart is relatively insensitive to detect small process average shifts. In this article, we introduce and investigate the basic features of the modified r out of m control chart. The new control chart outperforms the Shewhart control chart for small to moderate process average shifts and the corresponding r out of m control chart which has been recently appeared in the literature.
Active Health Monitoring of Aerospace Composite Structures by Embedded Piezoceramic Transducers (2001)

The objectives of the thesis work were to study theinteraction between embedded piezoceramic transducers andcomposite structures as well as determine techniques tosimplify the Lamb waves analysis. Firstly, this studyconsidered the design of the embedded piezoceramic transducers.Secondly, the effect of the embedded transducer on thecomposite strength as well as the influence of the mechanicallyloaded composite on the characteristics of the embeddedtransducer were investigated. Finally, to simplify the analysisof such complex Lamb wave responses, two techniques weredeveloped. They were based on the wavelet technique and amodelling technique, respectively. The design of the embedded piezoceramic transducers wasimproved by reducing the stress concentrations in the compositeas well as in all components constituting the piezoceramictransducer, that is, the piezoceramic element, interconnectorand conductive adhesive. The numerical analysis showed that thethickness of the interconnector had no significant influence onthe stress state of the piezoceramic transducer. It was alsofound that a compliant conductive adhesive reduced the stressconcentration located at the edge of the piezoceramic element.The structural integrity of composites embedded with theimproved piezoceramic transducer was investigated. Theexperiments, performed in tensile and compressive staticloading, indicated that the strength of the composite was notsignificantly reduced by the embedded piezoceramic transducer.Further investigations were conducted to evaluate theperformance of the improved piezoceramic transducer used as aLamb wave generator embedded in composites subjected tomechanical loading. The tests were conducted in tensile andcompressive static loading as well as fatigue loading. Thestudy showed a large working range of the embedded piezoceramictransducer. A post processing technique based on the waveletswas further assessed in the detection of damage and in thedamage size evaluation. A new wavelet basis was developedspecially for processing the Lamb wave response. This method,focused on the wavelet coefficients from the decomposition Lambwave response, showed promising results in evaluating thedamage size. The wavelets offered a sensitive tool to detectsmall damage, compared to other detection methods, improvingthe damage detection capabilities. The other technique wasdevoted to the simplification of the generated Lamb waves bythe use of multi-element transducers. The transducers weredesigned using both a normal-mode expansion and a FE-method.This technique allowed reducing the effect of a Lamb wave modetowards another. This technique was successfully implemented ina damage detection system in composites. <b>Keywords:</b>Embedded piezoceramic, transducer, composite,structural integrity, health monitoring, damage detection, Lambwaves, wavelets, normal-mode expansion, FE-method
Characterisation of the activator effect of glycogen on amylosucrase from Neisseria polysaccharea (2000)

Amylosucrase produces an insoluble α-1,4-linked glucan from sucrose, releasing fructose. In addition to polymerisation, in the presence of sucrose as sole substrate, amylosucrase catalyses sucrose hydrolysis and oligosaccharide synthesis in significant proportions. The effects of both glycogen acceptor and sucrose concentrations on the reactions catalysed by the highly purified amylosucrase from Neisseria polysaccharea were investigated. Sucrose hydrolysis decreased strongly with the increase of the concentration of glycogen, as did oligosaccharide synthesis, by glucose transfer onto glucose and fructose. The glucosyl units consumed were then preferentially used for elongation of glycogen chains. The study of the kinetic behaviour of amylosucrase revealed a strong, sucrose concentration dependent activator effect of glycogen. This activation was decreased at high sucrose concentration. The optimal sucrose concentrations increased with glycogen concentration, suggesting competition between sucrose and glycogen, and the presence of a second non-catalytic acceptor binding site which could bind various acceptors (glucose, maltose, glycogen) and also sucrose.
Glycine-Rich Proteins Encoded by a Nodule-Specific Gene Family Are Implicated in Different Stages of Symbiotic Nodule Development in <i>Medicago</i> Spp. (2002)

Four genes encoding small proteins with significantly high glycine content have been identified from root nodules of Medicago sativa. All of these proteins as well as their Medicago truncatula homologues carried an amino terminal signal peptide and a glycine-rich carboxy terminal domain. All except nodGRP3 lacked the characteristic repeat structure described for cell wall and stress response-related glycine-rich proteins (GRP). Expression of these GRP genes was undetectable in flower, leaf, stem, and hypocotyl cells, whereas expression was highly induced during root nodule development, suggesting that GRP genes act as nodulins. Moreover, none of these nodule-expressed GRP genes were activated by hormones or stress treatments, which are inducers of many other GRPs. In Rhizobium-free spontaneous nodules and in nodules induced by a noninfective mutant strain of Sinorhizobium meliloti, all these genes were repressed, while they were induced in Fix- nodules, unaffected in bacterial infection, but halted in bacteroid differentiation. These results demonstrated that bacterial infection but not bacteroid differentiation is required for the induction of the nodule-specific GRP genes. Differences in kinetics and localization of gene activation as well as in the primary structure of proteins suggest nonredundant roles for these GRPs in nodule organogenesis.
Investigation and Suppression of Current Zero Crossing Phenomenon for a Semicontrolled Open-Winding PMSG System (2016)

The semicontrolled open-winding PMSG system has been widely investigated due to its simplified topology and easy control implementation. Nevertheless, compared with the conventional controllable converter structure, the current zero crossing phenomenon will last a longer time in the semicontrolled configuration, which is determined by the phase displacement between voltage and current. Since a long current zero crossing duration will lead to voltage pulse disturbance, serious electromagnetic interference, and output power fluctuation, it is necessary to reduce the zero crossing duration to improve the open-winding PMSG performance. This paper gives a detailed analysis on the zero crossing phenomenon of the semicontrolled open-winding PMSG system in the 3-D space vector modulation perspective. Meanwhile, a third harmonic injection method is suggested to reduce the zero crossing duration. It is also demonstrated that the torque and power pulsation are effectively improved, while the zero-sequence current amplitude does not increase. A proportional resonant controller is used to regulate the desired zero-sequence current. The proposed method is validated in a 1-kW semicontrolled open-winding PMSG experimental system with i <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">d</sub> = 0 control method.
Serum cathepsin K and cystatin C concentration in patients with advanced non-small-cell lung cancer during chemotherapy. (2009)

A pathogenic implication of cathepsin K (Cath K) and its inhibitor - cystatin C (Cyst C) occur to be of growing importance in the mechanisms of tumor invasiveness in lung cancer. This study was conducted to investigate the prognostic role and the effects of chemotherapy on serum Cath K and Cyst C (ELISA) in patients with advanced stage non-small cell lung cancer (NSCLC). The study entered 40 patients (32 men) and 15 healthy volunteers (control group). Peripheral blood samples were taken before and after four cycles of chemotherapy. The mean serum Cyst C levels were significantly higher in patients with advanced NSCLC than in controls (p=0.003). The levels of Cath K in serum of NSCLC are comparable to those in controls. No correlation was found between Cath K and Cyst C concentrations and the histological type and staging of lung cancer. Patients with T4-stage had a lower level of Cyst C, than those with T2 (p=0.033). No correlation was found between the concentrations of Cath K, Cyst C and the effect of chemotherapy. However, Cyst C level positively correlated with serum creatinine concentration (R=0.535; p=0.005) in patients who responded to chemotherapy and with patient's age (R=0.456; p=0.018) in whole group. When the cut-off values of serum Cath K and Cyst C (23.35 pmol/l, 1.29 mg/l, respectively) were used, the prognoses of high and low groups were not different. Concluding, patients with lung cancer have a higher serum concentration of Cyst C compared to healthy people. In our opinion, determination of Cath K and Cyst C concentrations has no clinical significance in the prognosis of the survival time in lung cancer.
Small Molecule Mitochondrial F<sub>1</sub>F<sub>0</sub>ATPase Hydrolase Inhibitors as Cardioprotective Agents. Identification of 4-(<i>N</i>-Arylimidazole)-Substituted Benzopyran Derivatives as Selective Hydrolase Inhibitors (2004)

In this paper we show that 4-aryl-CH2-imidazole-substituted benzopyran compounds with 3S,4R-stereochemistry are cardioprotective by inhibiting the F1F0 mitochondrial ATP hydrolase. Compounds (e.g., 13) with 3R,4S-stereochemistry act as mitochondrial KATP openers. This resulted from an inversion of stereochemistry for the F1F0 mitochondrial ATP hydrolase vs mitochondrial KATP. Structure-activity relationships for the inhibition of mitochondrial ATP hydrolase are also delineated. It is not clear how 13 (3R,4S) can selectively inhibit the hydrolytic activity of the F1F0 mitochondrial enzyme without interfering with the synthase activity.
Robert E. Martin (1993)

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Highly Flexible Wrinkled Carbon Nanotube Thin Film Strain Sensor to Monitor Human Movement (2016)

Carbon nanotubes (CNTs) on shape memory polymers result in densified, nano- to microscale wrinkles upon heat-induced shrinkage. These wrinkled CNT bundles can be transferred into soft materials similar to the human epidermis for extremely highly stretchable skin mountable strain sensors with a dynamic range of over 700%. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Asparagine 229 Mutants of Thymidylate Synthase Catalyze the Methylation of 3-Methyl-2‘-deoxyuridine 5‘-Monophosphate (1996)

The conserved Asn 229 of thymidylate synthase (TS) forms a cyclic hydrogen bond network with the 3-NH and 4-O of the nucleotide substrate 2'-deoxyuridine 5'-monophosphate (dUMP). Asn 229 is not essential for substrate binding or catalysis [Liu, l., & Santi, D. B. (1993) Proc. Natl. Acad. Sci. U.S.A. 90, 8604-8608] but is a major determinant in substrate specificity [Liu, l., & Santi, D. V. (1993) Biochemistry 32, 9263-9267]. 3-Methyl-dUMP (3-MedUMP) is neither a substrate nor an inhibitor of wild type TS but is converted to 3-methyl 2'-deoxythymidine 5'-monophosphate by many TS Asn 229 mutants. Some of the Asn 229 mutants (N229C, -I, -M, -A, and -V) have kcat values for 3-MedUMP methylation which are up to about 20% of that for wild type TS-catalyzed methylation of dUMP, and some mutants (N229C and -A) catalyze methylation of 3-MedUMP more efficiently than that of dUMP. Mutants with hydrophobic side chains tended to be more active in catalysis of methylation of 3-MedUMP than those with hydrophilic side chains. The ability of 3-MedUMP to serve as a substrate for Asn 229 mutants shows that the active form of dUMP involves the neutral pyrimidine base and that ionization of the 3-NH group does not occur in the course of catalysis. In contrast to the negligible binding of 3-MedUMP to wild type TS, both 3-MedUMP and dUMP showed similar Km values with the Asn 229 mutants, suggesting similar binding affinities to the mutants. The X-ray crystal structure of the TS N229C--3-MedUMP complex showed that the side chain of Cys 229 was rotated away from the pyrimidine ring to allow placement of a water molecule and the 3-methyl group of 3-MedUMP in the active site. Our results suggest that the inability of 3-MedUMP to undergo methylation by wild type TS is due to its inability to bind to the enzyme, which in turn is simply a result of steric interference of the 3-methyl group with the side chain of Asn 229.
Analysis of aerodynamic characteristics of a liftbody aircraft (2013)

When the scramjet engine works,the disturbed flow field around the inlet and tail nozzle will make aerodynamic parameters changed.In this situation,the control system should ensure the vehicle's flight attitude.The paper studies the impact of different work situation and the diverse angle of control surface on aerodynamic parameters of hypersonic waverider vehicle.Accordingly,the analysis results of aerodynamic parameters of hypersonic vehicle are obtained under different work situation,providing important reference for the design of control arithmetic.
Effect of tissue non-specific alkaline phosphatase in maintenance of structure of murine colon and stomach (2000)

The gastrointestinal tract of mammals secretes a phospholipid-rich membrane that is enriched in alkaline phosphatase (AP) and surfactant proteins (surfactant-like particle, SLP). The production of this particle is stimulated in the small intestine by fat feeding and in cultured cells in vitro by transfection with intestinal alkaline phosphatase (IAP). To test whether tissue non-specific alkaline phosphatase (TNAP) was a factor in stimulating surfactant-like particle production in stomach and colon (tissues expressing TNAP), mice lacking this enzyme were studied. Mice were harvested at 8 days of life, when body weight of homozygous animals (TNAP -/-) was about half that of congenic controls (TNAP +/+) or heterozygotes (TNAP +/-), but before seizures had begun. No difference in content of the major SLP protein (65 kDa) by Western blotting or immunocytochemistry was seen in stomach or colon of TNAP -/- vs. TNAP +/+ animals, but the content was only about half in the IAP-expressing small bowel. Transmission electron microscopy of the TNAP -/- small bowel showed large dilated lysosomes and residual bodies. Colonocytes and gastric surface epithelial cells from the same animals showed mitochondria containing homogeneous dense inclusions, consistent with neutral lipid. In the underweight homozygous animals, there was a decrease in the neuronal content of submucosal ganglia in the jejunum and ileum and of myenteric ganglia in the jejunum of TNAP -/- animals. These findings suggest that (1) TNAP is not important in maintaining surfactant-like particle content of tissues that express TNAP, (2) normal fat absorption is important in maintaining SLP content in the small intestine, and (3) TNAP is important in the maintenance of some intestinal structures, and perhaps their function.
Protect-seq: genome-wide profiling of nuclease inaccessible domains reveals physical properties of chromatin (2019)

In metazoan cell nuclei, heterochromatin constitutes large chromatin domains that are in close contact with the nuclear lamina. These heterochromatin/lamina-associated domains (LADs) domains are difficult to profile and warrants a simpler and direct method. Here we report a new method, Protect-seq, aimed at identifying regions of heterochromatin via resistance to nuclease degradation followed by next-generation sequencing (NGS). We performed Protect-seq on the human colon cancer cell line HCT-116 and observed overlap with previously curated LADs. We provide evidence that these protected regions are enriched for and can distinguish between the repressive histone modification H3K9me3, H3K9me2 and H3K27me3. Moreover, in human cells the loss of H3K9me3 leads to an increase in chromatin accessibility and loss of Protect-seq signal. For further validation, we performed Protect-seq in the fibrosarcoma cell line HT1080 and found a similar correlation with previously curated LADs and repressive histone modifications. In sum, Protect-seq is an efficient technique that allows rapid identification of nuclease resistant chromatin, which correlate with heterochromatin and radial positioning.
More Is Sometimes Less: Education's Effects on Tolerance (1994)

(1994). More Is Sometimes Less: Education's Effects on Tolerance. Review of Education, Pedagogy, and Cultural Studies: Vol. 16, No. 3-4, pp. 297-314.
A tool for describing and evaluating hierarchical real-time bus scheduling policies (2003)

We present a tool suite for building, simulating, and analyzing the results of hierarchical descriptions of the scheduling policy for modules sharing a bus in real-time applications. These schedules can be based on a variety of factors including characteristics of messages and time slicing and are represented in a hierarchical tree-like structure that specifies multiple levels of arbitration. This structure can describe many popular arbitration schemes. Our simulator evaluates the specified scheduling structure on a set of message traces for a given bus. We illustrate our approach by applying it to two examples: the SAE Automotive Benchmark and Voice Over IP (VoIP). Although this paper deals with just bus scheduling policies, the approach can be easily extended to other real-time scheduling problems.
Edge-emitting microlasers with a single quantum dot active layer (2002)

We have realized edge emitting microlasers on a GaInAs-AlGaAs quantum dot laser structure with deeply etched DBR mirrors. Lasers with 40 /spl mu/m cavity length show CW operation at room temperature, exhibiting threshold currents below 4 mA. CW output powers exceed 5 mW for 40 /spl mu/m long lasers emitting from the ground state at 980 nm.
A novel Bluetooth antenna on flexible substrate for smart clothing (2002)

The development of wearable computer systems and smart clothing has been rapid. They are becoming more and more lightweight and soon we should see a wide range of unobtrusive wearable and ubiquitous computing equipment integrated into everyday wear. Rapid progress in wireless communication promises to replace wired-communication networks, in which antennas play a more important role. This paper presents an antenna design for wearable applications. Due to wearable system demands this paper discusses mainly physically small planar antennas. A design example is given in which a flexible PIFA (FlexPIFA) structure for single and dual-band operation is introduced into smart clothing in Bluetooth and UMTS fields. To our knowledge this is first time a thin and flexible antenna has been designed for commercial smart clothing. Measured results are compared with simulations and good agreement was observed. In addition the effect of the human body on antenna performance is discussed.
Inhibition of DNA synthesis and oncogene expression in tumor cells by the biological factor DIF. (1991)

A regulatory factor isolated from the maternal part of bovine placentas (decidua inhibitory factor, DIF) inhibits the incorporation of thymidine into the DNA of a variety of animal and human tumors. The degree of inhibition is dependent on the concentration of the factor. Results indicate that signal transduction occurs via a Ca2+ mobilizing pathway after specific binding of the inhibitor to tumor cell surface receptors. On of the main consequences of DIF action is the inhibition of c-fos and c-myc expression and/or degradation.
Stochastic computing and reinforcement neural networks (1989)

This paper considers reinforcement learning neural networks using associative reward/penalty elements. Fundamental theory and applications of relevant stochastic learning automata are reviewed followed by a discussion of associative reward/penalty structures and recent work on reinforcement neural networks. The paper concludes with a consideration of the use of stochastic computing techniques for the hardware synthesis of neural networks. >
Thermal regulation as control reference in electric drives (2012)

Recognition of technical specification for electric drives thermal sizing is quite challenging in both transportation applications and distributed generating systems. In particular, components of electric drives for hybrid farm equipment, like tractors as well large combines, are often overstressed because of either high ambient temperature or overload working condition. The electric drive components are mainly chosen with reference to average power and energy considerations; however, overload operating conditions can occur for time durations not established in advance, as well quite unpredictable thermal conditions are associated to environment related to diesel engines in hybrid configurations. For this reason, it is convenient to provide the control system of the electric drive unit with a sort of thermal regulation of the electric and electronic equipment, which can be achieved by adjusting some operating conditions, as dc-link voltage, modulation strategy and switching frequency, in order to reduce thermal stress on either power electronic devices or electrical machines windings.