gebhart/patrepeval huggingface dataset:
Synergistic Effects of Polyphenols and Methylxanthines with Leucine on AMPK/Sirtuin-Mediated Metabolism in Muscle Cells and Adipocytes (2014)

The AMPK-Sirt1 pathway is an important regulator of energy metabolism and therefore a potential target for prevention and therapy of metabolic diseases. We recently demonstrated leucine and its metabolite β-hydroxy-β-methylbutyrate (HMB) to synergize with low-dose resveratrol (200 nM) to activate sirtuin signaling and stimulate energy metabolism. Here we show that leucine exerts a direct effect on Sirt1 kinetics, reducing its Km for NAD(+) by >50% and enabling low doses of resveratrol to further activate the enzyme (p = 0.012). To test which structure elements of resveratrol are necessary for synergy, we assessed potential synergy of structurally similar and dissimilar polyphenols as well as other compounds converging on the same pathways with leucine using fatty acid oxidation (FAO) as screening tool. Dose-response curves for FAO were constructed and the highest non-effective dose (typically 1-10 nM) was used with either leucine (0.5 mM) or HMB (5 µM) to treat adipocytes and myotubes for 24 h. Significant synergy was detected for stilbenes with FAO increase in adipocytes by 60-70% (p<0.05) and in myotubes >2000% (p<0.01). Sirt1 and AMPK activities were stimulated by ∼65% (p<0.001) and ∼50% (p<0.03), respectively. Similarly, hydroxycinnamic acids and derivatives (chlorogenic, cinnamic, and ferulic acids) combined with leucine/HMB increased FAO (300-1300%, p<0.01), AMPK activity (50-150%, p<0.01), and Sirt1 activity (∼70%, p<0.001). In contrast, more complex polyphenol structures, such as ellagic acid and epigallocatechin gallate required higher concentrations (>1 µM) and exhibited little or no synergy. Thus, the six-carbon ring structure bound to a carboxylic group seems to be a necessary element for leucine/HMB synergy with other stilbenes and hydroxycinnamic acids to stimulate AMPK/Sirt1 dependent FAO; these effects occur at concentrations that produce no independent effects and are readily achievable via oral administration.
C-Glycosylflavonoids. III. The Synthesis of 5,7,4'-Tri-O-methylvitexin (8-C-β-D-Glucopyranosyl-5,7,4'-trimethoxyflavone) (1979)

The reaction between 1,3,5-trimethoxybenzene and tetraacetyl-a-D-glucosyl bromide in the presence of zinc oxide gave ß-D-glucopyranosyl-2,4,6-trimethoxybenzene tetraacetate (12). The tetraacetate (12) was converted by acetic anhydride and anhydrous aluminium chloride into 3-ß-D- glucopyranosyl-2-hydroxy-4,6-dimethoxyacetophenone tetraacetate (15). Condensation of the acetophenone tetraacetate (15) with 4-methoxybenzaldehyde in the presence of sodium hydroxide gave 3'-ß-D-glucopyranosyl-2'-hydroxy-4,4',6'-trimethoxychacone (6). Reaction of the chalcone (6) with selenium dioxide gave 8-C-ß-D-glucopyranosyl-5,7,4'-trimethoxyflavone (5,7,4'-tri- O - methylvitexin)(10). The chemical shifts of the olefinic protons of chalcones are discussed.
A Survey of Keystroke Dynamics Biometrics (2013)

Research on keystroke dynamics biometrics has been increasing, especially in the last decade. The main motivation behind this effort is due to the fact that keystroke dynamics biometrics is economical and can be easily integrated into the existing computer security systems with minimal alteration and user intervention. Numerous studies have been conducted in terms of data acquisition devices, feature representations, classification methods, experimental protocols, and evaluations. However, an up-to-date extensive survey and evaluation is not yet available. The objective of this paper is to provide an insightful survey and comparison on keystroke dynamics biometrics research performed throughout the last three decades, as well as offering suggestions and possible future research directions.
Event-Based Haptics and Acceleration Matching: Portraying and Assessing the Realism of Contact (2005)

Contact in a typical haptic environment resembles the experience of tapping on soft foam, rather than on a hard object. Event-based, high-frequency transient forces must be superimposed with traditional proportional feedback to provide realistic haptic cues at impact. We have developed a new method for matching the accelerations experienced during real contact, inverting a dynamic model of the device to compute appropriate force feedback transients. We evaluated this haptic rendering paradigm by conducting a study in which users blindly rated the realism of tapping on a variety of virtually rendered surfaces as well as on three real objects. Event-based feedback significantly increased the realism of the virtual surfaces, and the acceleration matching strategy was rated similarly to a sample of real wood on a foam substrate. This work provides a new avenue for achieving realism of contact in haptic interactions.
Reexamination of Hexafluorosilicate Hydrolysis by <sup>19</sup>F NMR and pH Measurement (2006)

The dissociation of hexafluorosilicate has been reinvestigated due to recent suggestions that fluorosilicate intermediates may be present in appreciable concentrations in drinking water. 19F NMR spectroscopy has been used to search for intermediates in the hydrolysis of hexafluorosilicate. No intermediates were observable at 10(-5) M concentrations under excess fluoride forcing conditions over the pH range of 3.5-5. A single intermediate species, assigned as SiF5(-) or its hydrate, was detected below pH 3.5. At moderate pH values of 4 and 5 silica oligomerization in the solutions studied made it difficult to directly determine the hexafluorosilicate equilibrium constant. Under more acidic conditions the average pKd, or negative log of the dissociation constant Kd, determined by 19F NMR measurements, was 30.6. We also investigated the behavior of hexafluorosilicate in common biological buffer reagents including phosphate/citrate, veronal/HCI buffers, and Ringer's solution. The buffer capacity of all of these systems was found to be insufficient to prevent acidic shifts in pH when hexafluorosilicate was added. The pH change is sufficient explanation for the observed inhibition of acetylcholinesterase that was previously attributed to hexafluorosilicate hydrolysis intermediates.
Hydrogen glucose breath test to detect small intestinal bacterial overgrowth: a prevalence case–control study in irritable bowel syndrome (2005)

The present case-control study showed an epidemiological association between irritable bowel syndrome and small intestinal bacterial overgrowth. Placebo-controlled small intestinal bacterial overgrowth-eradication studies are necessary to clarify the real impact of small intestinal bacterial overgrowth on irritable bowel syndrome symptoms.
MAP4K1 functions as a tumor promotor and drug mediator for AML via modulation of DNA damage/repair system and MAPK pathway (2021)

This study demonstrates that MAP4K1 not only regulates HHT resistance but also independently predicts AML prognosis. In addition, understanding the regulatory mechanism of MAP4K1 reveals novel treatment strategies for resistant and refractory AML. Fundings: This work was supported by the National Natural Science Foundation of China (NSFC) (Grant No.81800199, 81670124, 82070118) and the Natural Science Foundation of Zhejiang Province (LY20H080008).
One month evaluation of the manually rotating "Bio-Bright" toothbrush for clinical safety and efficiency. (1995)

A clinical trial, based on the guidelines of the American Dental Association, was conducted to evaluate the efficacy and safety of Bio-Bright, a new manually rotating toothbrush. The brush was used by 28 adults and compared to a group of 26 adults who used an ADA-accepted toothbrush (Oral-B 35). Examinations were recorded for safety, plaque level, gingival inflammation and gingival bleeding at baseline, 15 days and one month. Analysis of the data revealed no statistically significant differences between the two groups at any of the measurement periods. When calculating the cumulative longitudinal effect on plaque increase or decrease, a consistent and statically significant advantage was revealed for the Bio-Bright group, as compared to the control. No significant differences were demonstrated when comparing safety, gingival, and bleeding indices between the two groups.
Use of Bird Activity Modulation Waveforms in Radar Identification. (1972)

Abstract : Positive on-line1' identification of any target is very difficult using primary radar. Single birds modulate radar echo signals with periodic waveforms related to their wingbeat frequency and to their wing flapping and wing rest periods. Data from these complex waveforms can be extracted by radar signature analysis methods and compared with corresponding data obtained from known species (by tracking them with a radar fitted with a telescope). Identification is obtained by correlating known and unknown data. Actual on-line identification appears feasible if a comprehensive catalogue of waveforms and other flight characteristics of known species is collected and used. These methods can immediately be put to use in investigating the, distribution of species hazardous to aircraft.
Genetic Linkage and Cotransfer of a Novel, <i>vanB</i> -Containing Transposon (Tn <i>5382</i> ) and a Low-Affinity Penicillin-Binding Protein 5 Gene in a Clinical Vancomycin-Resistant <i>Enterococcus faecium</i> Isolate (1998)

Mechanisms for the intercellular transfer of VanB-type vancomycin resistance determinants and for the almost universal association of these determinants with those for high-level ampicillin resistance remain poorly defined. We report the discovery of Tn5382, a ca. 27-kb putative transposon encoding VanB-type glycopeptide resistance in Enterococcus faecium. Open reading frames internal to the right end of Tn5382 and downstream of the vanXB dipeptidase gene exhibit significant homology to genes encoding the excisase and integrase of conjugative transposon Tn916. The ends of Tn5382 are also homologous to the ends of Tn916, especially in regions bound by the integrase enzyme. PCR amplification experiments indicate that Tn5382 excises to form a circular intermediate in E. faecium. Integration of Tn5382 in the chromosome of E. faecium C68 has occurred 113 bp downstream of the stop codon for the pbp5 gene, which encodes high-level ampicillin resistance in this clinical isolate. Transfer of vancomycin, ampicillin, and tetracycline resistance from C68 to an E. faecium recipient strain occurs at low frequency in vitro and is associated with acquisition of a 130- to 160-kb segment of DNA that contains Tn5382, the pbp5 gene, and its putative repressor gene, psr. The interenterococcal transfer of this large chromosomal element appears to be the primary mechanism for vanB operon spread in northeast Ohio. These results expand the known family of Tn916-related transposons, suggest a mechanism for vanB operon entry into and dissemination among enterococci, and provide an explanation for the nearly universal association of vancomycin and high-level ampicillin resistance in clinical E. faecium strains.
Building local bond markets : an Asian perspective (2000)

this paper , including lack of money mary W&apos; and futur es contrWb&apos;qB The absence of marGRGx for CP and futurOx r eflects the reWqkBOB of the SBP and SECP to past mater&apos;qk goverqkqOW prve lems in Pakistan. Since shorW selling is not per&apos;xx&apos;BWb it is also difficult to develop a secondarG marond Today, the small cor WG&apos;9O debt securOWbGx marrO is overqkzz owed by the size of goverx&apos;WbG borrx&apos;WbGq The przBzkxWb employed in issuing rsuing and wholesale goverale W secur9WbG&apos; must be changed in ork&apos;R to develop a morz efficient yield cur Wfor goverxkBxW securB9OWbG The necessarW changes should be identified with the help of the MOF and SBP. The SBP should begin selling long-ter m tenor in gover nment securRWbkx thr ough auction. The MOF should discour age investments in the r WGq9 goverz9Wbk savings cergs WzGG9G by wholesale investor The major constrbkkO&apos; facing the cor&apos;Gz9GW debt marGkR at prWzx9 arW the limited supply of TFCs, the lengthy for apprhy W drpr prrhy W&apos;ROGO issue costs,
In vitro Activity of Combination Therapy with Cefepime, Piperacillin-Tazobactam, or Meropenem with Ciprofloxacin against Multidrug-Resistant <i>Pseudomonas aeruginosa</i> Strains (2003)

The prevalence of multidrug-resistant Pseudomonas aeruginosa strains has been increasing every year, and treatment with various antimicrobial combinations has been offered alternatively in the clinical practice. The aim of this study was to evaluate the in vitro effects of combinations of meropenem, cefepime, or piperacillin-tazobactam with ciprofloxacin against multidrug-resistant P. aeruginosa strains by the time-kill method. The results show that both the combination of two beta lactams with ciprofloxacin and three beta lactams with ciprofloxacin against 4 of 5 multidrug-resistant P. aeruginosa strains has no effect in vitro. The combination of one beta lactam (meropenem, cefepime, piperacillin-tazobactam) with ciprofloxacin has a synergistic effect against one strain of multidrug-resistant P. aeruginosa that is ciprofloxacin susceptible and resistant to meropenem, cefepime, and piperacillin-tazobactam. None of the combinations had an antagonistic effect against these multidrug-resistant strains.
Selective suppression of artifact‐generating echoes in cine DENSE using through‐plane dephasing (2006)

In displacement-encoded imaging with stimulated echoes (DENSE), tissue displacement is encoded in the phase of the stimulated echo. However, three echoes generally contribute to the acquired signal (the stimulated echo, the complex conjugate of the stimulated echo, and an echo due to T(1) relaxation). It is usually desirable to suppress all except the stimulated echo, since otherwise the additional echoes will cause displacement measurement errors. Ideally, suppression of the artifact-generating echoes would be independent of time, T(1), and displacement-encoding frequency, and would not require additional acquisitions. In this study through-plane gradients were used to selectively dephase artifact-generating echoes without causing significant signal loss of the stimulated echo. A cine DENSE sequence was modified to include dephasing gradients and perform complementary spatial modulation of magnetization (CSPAMM). For single-acquisition cine DENSE using dephasing alone, artifact suppression was similar to CSPAMM with two acquisitions. The use of dephasing with CSPAMM required two acquisitions, but demonstrated greater artifact suppression than CSPAMM alone or dephasing alone.
Decision Support for Video-based Detection of Flu Symptoms (2020)

The development of decision support systems is a growing domain that can be applied in the area of disease control and diagnostics. Using video-based surveillance data, skeleton features are extracted to perform action recognition, specifically the detection and recognition of coughing and sneezing motions. Providing evidence of flu-like symptoms, a decision support system based on causal networks is capable of providing the operator with vital information for decision-making. A modified residual temporal convolutional network is proposed for action recognition using skeleton features. This paper addresses the capability of using results from a machine-learning model as evidence for a cognitive decision support system. We propose risk and trust measures as a metric to bridge between machine-learning and machine-reasoning. We provide experiments on evaluating the performance of the proposed network and how these performance measures can be combined with risk to generate trust.
STUDIES ON THE LIPID OF BCG (1956)

In the previous study on mycolic acid complex in Mycobacterium tuberculosis it was established that glyceryl mono-mycolate was a component in wax C fraction of BCG (Tsumita, 1956) . However, considering the solubility of glyceryl monomycolate, it can be considered that a substance closely related with it might be present also in wax A fraction of BCG, which is extractable with alcoholether (1: 1) from tubercle bacilli and soluble in hot acetone.Asselineau (1951) reported that wax A fraction of a human virulent strain of tubercle bacilli, Test, was composed of free mycolic acid, phthiocerylesters of fatty acids and a lipidic substance with a molecular formula of C60H120O.On saponification of alcohol-ether soluble wax, Wieghard and Anderson (1938) obtained mycolic, hexacosanoic, stearic and palmitic acids from the fatty acid fraction and phthiocerol from the neutral fraction and glycerol and sugars from the water soluble fraction.The author fractionated wax A of BCG into three portions by aluminum oxide chromatography. It is the purpose of this paper to describe the fact that one of them was glyceryl mono-mycolate, which gave two kinds of mycolic acid on hydrolysis.
Microsoft SharePoint Foundation 2010 Step by Step (2011)

Experience learning made easy-and quickly teach yourself how to use Microsoft SharePoint Foundation to enable effective team collaboration. With Step By Step, you set the pace-building and practicing the skills you need, just when you need them!Build your own SharePoint site with easy-to-use templates Create lists and libraries to store information Add discussion boards, wikis, and blogs Set up Document and Meeting Workspaces for easy collaboration Share calendars, contacts, and data from Microsoft Office programs Customize your pages with Web Parts Your all-in-one learning experience includes:Files for building skills and practicing the book's lessons Plus other resources on the Web
Spatial characterization of the response of a silica optical fiber to wideband ultrasound (2012)

Optical fibers have long been recognized as a promising technology for remote sensing of ultrasound. Nonetheless, very little is known about the characteristics of their spatial response, which is significantly affected by the strong acoustic mismatches between the fiber and surrounding medium. In this Letter, a new method is demonstrated for wideband spatial acoustic characterization of optical fibers. The method is based on the excitation of a point-like acoustic source via the opto-acoustic effect, while a miniature fiber sensor is implemented by a π-phase-shifted fiber Bragg grating. Despite the relative complexity of acoustic wave propagation in the fiber, its spatial sensitivity in the high frequency band (6-30 MHz) exhibited an orderly pattern, which can be described by a simple model. This property reveals new possibilities for high-performance imaging using fiber-based ultrasound sensors, where knowledge of the sensor's spatial sensitivity map is generally required.
Generic, geometric finite element analysis of the transtibial residual limb and prosthetic socket. (1997)

Finite element (FE) analysis was used to investigate the stress distribution between the residual limb and prosthetic socket of persons with transtibial amputation (TTA). The purpose of this study was to develop a tool to provide a quantitative estimate of prosthetic interface pressures to improve our understanding of residual limb/prosthetic socket biomechanics and prosthetic fit. FE models of the residual limb and prosthetic socket were created. In contrast to previous FE models of the prosthetic socket/residual limb system, these models were not based on the geometry of a particular individual, but instead were based on a generic, geometric approximation of the residual limb. These models could then be scaled for the limbs of specific individuals. The material properties of the bulk soft tissues of the residual limb were based upon local in vivo indentor studies. Significant effort was devoted toward the validation of these generic, geometric FE models; prosthetic interface pressures estimated via the FE model were compared to experimentally determined interface pressures for several persons with TTA in a variety of socket designs and static load/alignment states. The FE normal stresses were of the same order of magnitude as the measured stresses (0-200 kPa); however, significant differences in the stress distribution were observed. Although the generic, geometric FE models do not appear to accurately predict the stress distribution for specific subjects, the models have practical applications in comparative stress distribution studies.
Long-chain n-3 fatty acids and inflammation: potential application in surgical and trauma patients (2003)

Lipids used in nutritional support of surgical or critically ill patients have been based on soybean oil, which is rich in the n-6 fatty acid linoleic acid (18:2n-6). Linoleic acid is the precursor of arachidonic acid (20:4n-6). In turn, arachidonic acid in cell membrane phospholipids is the substrate for the synthesis of a range of biologically active compounds (eicosanoids) including prostaglandins, thromboxanes, and leukotrienes. These compounds can act as mediators in their own right and can also act as regulators of other processes, such as platelet aggregation, blood clotting, smooth muscle contraction, leukocyte chemotaxis, inflammatory cytokine production, and immune function. There is a view that an excess of n-6 fatty acids should be avoided since this could contribute to a state where physiological processes become dysregulated. One alternative is the use of fish oil. The rationale of this latter approach is that fish oil contains long chain n-3 fatty acids, such as eicosapentaenoic acid. When fish oil is provided, eicosapentaenoic acid is incorporated into cell membrane phospholipids, partly at the expense of arachidonic acid. Thus, there is less arachidonic acid available for eicosanoid synthesis. Hence, fish oil decreases production of prostaglandins like PGE2 and of leukotrienes like LTB4. Thus, n-3 fatty acids can potentially reduce platelet aggregation, blood clotting, smooth muscle contraction, and leukocyte chemotaxis, and can modulate inflammatory cytokine production and immune function. These effects have been demonstrated in cell culture, animal feeding and healthy volunteer studies. Fish oil decreases the host metabolic response and improves survival to endotoxin in laboratory animals. Recently clinical studies performed in various patient groups have indicated benefit from this approach.
SLAMBooster: An Application-aware Controller for Approximation in SLAM (2018)

Simultaneous Localization and Mapping (SLAM) is the problem of constructing a map of a mobile agent's environment while localizing the agent within the map. Dense SLAM algorithms perform reconstruction and localization at pixel granularity. These algorithms require a lot of computational power, which has hindered their use on low-power resource-constrained devices. Approximate computing can be used to speed up SLAM implementations as long as the approximations do not prevent the agent from navigating correctly through the environment. Previous studies of approximation in SLAM have assumed that the entire trajectory of the agent is known before the agent starts, and they have focused on offline controllers that set approximation knobs at the start of the trajectory. In practice, the trajectory is not known ahead of time, and allowing knob settings to change dynamically opens up more opportunities for reducing computation time and energy. We describe SLAMBooster, an application-aware, online control system for dense SLAM that adaptively controls approximation knobs during the motion of the agent. SLAMBooster is based on a control technique called proportional-integral-derivative (PID) controller but our experiments showed this application-agnostic controller led to an unacceptable reduction in localization accuracy. To address this problem, SLAMBooster also exploits domain knowledge for controlling approximation by performing smooth surface detection and pose correction. We implemented SLAMBooster in the open-source SLAMBench framework and evaluated it on several trajectories. Our experiments show that on the average, SLAMBooster reduces the computation time by 72% and energy consumption by 35% on an embedded platform, while maintaining the accuracy of localization within reasonable bounds. These improvements make it feasible to deploy SLAM on a wider range of devices.