gebhart/patrepeval huggingface dataset:
REGULATION OF THE INDUCTIVE PHASE OF MICROSPORE EMBRYOGENESIS IN BRASSICA NAPUS (1996)

In cultured microspores from Brassica napus, embryogenesis can be synchronously and irreversibly induced by elevating the culture temperature to 32°C for a minimum of 8 h. Culture at 18°C allows gametophytic development to continue, and results in the formation of pollen in vitro. This allows us to study the temperature controlled switch in developmental fate from gametophytic development to embryogenic development by molecular means. Analysis of protein synthetic patterns by [35S]-methionine incorporation and 2-dimensional gel electrophoresis, revealed that 25 proteins were differentially synthesized during the induction of microspore embryogenesis. Most of these proteins (17) appeared to belong to the class of heat shock proteins (HSPs). Four of these HSPs have been identified by Western blotting using antibodies raised against HSP17, HSP68 and HSP70. One protein that was only synthesized under embryogenic culture conditions, and did not belong to the heat inducible HSPs, is a candidate marker for early embryogenic development.
Study of Text Segmentation and Recognition Using Leap Motion Sensor (2016)

Recognition of 3-D texts drawn by fingers using Leap motion sensor can be challenging for existing text recognition frameworks. The texts sensed by Leap motion device are different from traditional offline and on-line writing systems. This is because of frequent jitters and non-uniform character sizes while writing using Leap motion interface. Moreover, because of air writing, characters, words, and lines are usually connected by continuous stroke that makes it difficult to recognize. In this paper, we present a study of segmentation and recognition of text recorded using Leap motion sensor. The segmentation task of continuous text into words is performed using a heuristic analysis of stroke length between two successive words. Next, the recognition of each segmented word is performed using sequential classifiers. In this paper, we have performed 3-D text recognition using hidden Markov model (HMM) and bidirectional long short-term memory neural networks (BLSTM-NNs). We have created a data set consisting of 560 Latin sentences drawn by ten participants using Leap motion sensor for experiments. An accuracy of 78.2% has been obtained in word segmentation, whereas 86.88% and 81.25% accuracies have been recorded in word recognition using BLSTM-NN and HMM classifiers, respectively.
Isotope Separation in Plasmas by Use of Ion Cyclotron Resonance (1976)

Selective ion-cyclotron-resonance acceleration of individual K, Ne, Cl, A, and Xe isotopes has been observed in plasmas of density ${10}^{9}$ to ${10}^{11}$ ${\mathrm{cm}}^{\ensuremath{-}3}$. Energy discriminating probes show good resolution of accelerated species in all cases. Mass spectrometer analyses of potassium samples, collected on cooled tungsten ribbons, showed $^{41}\mathrm{K}$ to $^{39}\mathrm{K}$ abundance ratios of 4 rather than the normal value of 0.07.
Effects of porcine follicular fluid on male pronucleus formation in porcine oocytes matured in vitro (1988)

Porcine follicular oocytes, collected from antral follicles (2-5 mm in diameter) of gilt ovaries, were matured in vitro with or without porcine follicular fluid (pFF), gonadotrophins (GTH) or fetal calf serum (FCS) for 48 hours at 37 degrees C under 5% CO2 in air, and their ability of male pronucleus (mPN) formation was examined after in vitro fertilization. Formation of mPN was observed in 38.6% of penetrated oocytes matured in modified Krebs-Ringer bicarbonate solution (TYH) 18 hours after insemination. The addition of GTH into the maturation medium did not improve the proportion of mPN-formed oocytes (20-30%). In contrast, the mPN formation rate elevated significantly (59.5%) when the oocytes were cultured with pFF, and the addition of follicle-stimulating hormone (FSH) enhanced this pFF action (the rate became 81.0%). In the presence of FSH, significant pFF effect was observable at the concentration of 5%, and its efficiency was elevated with the increase of pFF concentration. When the oocytes were matured with FCS, the mPN formation rate was unchanged or decreased rather than improved (0-25%). These results suggest that pFF, but not FCS, have substance(s) stimulating the ability of mPN formation in porcine oocytes.
Protective Role of Faecal pH in Experimental Colon Carcinogenesis (1985)

There is epidemiological evidence that populations with alkaline stool pH are at greater risk for colon cancer than populations with acid stool pH. This association was investigated in the laboratory using the rat-dimethylhydrazine colon carcinogenesis model. Rats with acid stool pH, produced by consumption of lactulose or sodium sulphate or both, had significantly fewer colon tumours after injections of dimethylhydrazine (DMH) than rats treated with DMH alone. The results confirm the hypothesis that acidification of the stool can protect against the induction of colon cancer.
Treatment of obesity: an update on anti‐obesity medications (2003)

The information presented in this article provides an overview of physiological agents, therapeutics in current use, and medications that have been extensively used in the past but are no longer available, or are not classically considered as anti-obesity drugs. The authors present an extensive review on the criteria for anti-obesity management efficacy, on physiological mechanisms that regulate central and/or peripheral action energetic homeostasis (nutrients, monoamines and peptides), and on beta-phenethylamine pharmacological-derivative agents (fenfluramine, dexfenfluramine, phentermine, diethylpropion, fenproporex and sibutramine), tricyclic derivatives (mazindol), phenylpropanolamine derivatives (ephedrine, phenylpropanolamine), a phenylpropanolamine oxy-tri-fluor-phenyl derivative (fluoxetine), a naftilamine derivative (sertraline) and a lipstatine derivative (orlistat). An analysis of all clinical trials longer than 10 weeks in duration is also presented for medications used in the management of obesity.
Minimum Deterrence: Examining the Evidence (2014)

Preface Executive Summary I. Introduction: Minimum Deterrence II. Minimum Deterrence and U.S. Policy III. Minimum Deterrence: Assumptions, Logic and Conclusions IV. Examining and Testing the Fundamental Assumptions and Logic of Minimum Deterrence V. Summary and Conclusion: How Does Minimum Deterrence Fare Against Available Evidence and What Alternative Guidelines May Be Better? Notes Appendix
정신보건 : 서울시 정신건강증진모형 구축을 위한 실태조사 (2012)

연구목적： 본 연구는 서울시의 지역정신보건센터에서 수행하는 정신건강증진사업의 실태를 살펴봄으로써 향후 정신건강증진서비스의 새로운 모형을 구성하는데 기초자료를 제공하고자 하였다. 연구방법：서울시 지역정신보건센터의 팀장을 대상으로 설문조사를 실행하였다. 설문 후 데이터의 신뢰성을 높이기 위해 전화 및 이 메일을 통해 보완작업을 하였으며, SPSS 18.0을 이용하여 기술통계분석을 실시하였다. 연구결과：서울시 지역정신보건센터에서의 정신건강증진사업 예산 중 45.2%가 아동청소년영역에 투입되고 있었고, 그 다음이 우울 및 자살예방영역 42.4%로 나타났다. 영역별 평균 수행인력은 아동청소년 2.1명, 알코올 1.0명, 우울 및 자살 2.3명, 기타1.0명으로 나타났다. 아동청소년 및 알코올사업영역은 고위험군을 대상으로 한 상담 및 프로그램(증진사업) 비중이 높게 나타났고, 우울 및 자살사업영역은 타 사업에 비해 일반인구를 대상으로 일차예방사업을 주로 하고 있었다. 결론：효과적인 정신건강증진서비스를 제공하기 위해서는 표준적 가이드라인 제시 및 근거에 기반한 프로그램 배포가 필요하다.
From Egyptian to Egyptianizing in Cypriot Glyptic of the Late Bronze Age (2013)

The 228 contextualized seals at Enkomi allow for detailed views into how Egyptian seal types were used in the Late Bronze Age (ca. 1650–1050 BCE) in one settlement on Cyprus. Over time the emphasis shifted from Egyptian seal rings and uncarved scarabs and scaraboids in tombs to Egyptianizing designs on Cypriot cylinder and conoid stamp seals that recalled the carved details on the bottoms of scarabs. On Cyprus, the most common seal shape was the cylinder, valued there and in the Near East for its inherent longevity of authority. The scarab, which as an amulet referencing regeneration, was similarly valued for its promise of long-term, continual renewal. People at Enkomi and elsewhere on Cyprus who sought changes in the authority represented by the cylinder seal experimented with the scarab as an acceptable and effective alternative model for crafting new tools of control at the end of the Bronze Age.
Test purpose generation for service evolutions (2009)

We propose an approach to test service evolution in the context of service oriented systems. Such systems are composed of orchestrations which interact with users and coordinate services to fulfill users' requests. The tester only interacts with services through orchestrations. We propose to use symbolic execution techniques in a model based black box approach to identify test purpose characterizing first class citizen behaviors to be tested. We discuss how test purposes characterized before a service evolution may be qualified as: obsolete test purposes (no more relevant after the evolution) non regression test purposes (not impacted by the evolution) and how to identify new emergent test purposes that reflect behaviors induced by the service evolution.
A superfamily of<i>Drosophila</i>satellite related (SR) DNA repeats restricted to the X chromosome euchromatin (1992)

The 1.688 g/cm3 class of Drosophila satellite DNA is predominantly localized to the centromeric heterochromatin of the X chromosome. We report here the existence of 1.688 satellite related (SR) DNA arrays present at numerous locations throughout the euchromatic portion of the X. Unlike their heterochromatic counterparts, euchromatic SRs consist of a small number of repeating units (usually 2-4), each of which is 63-81% identical to the 359-bp monomer of the 1.688 satellite. Although it appears that SR DNA arrays are not transcribed, in at least two cases, they are located adjacent to transcriptionally active genes. SR sequences also have significant similarity to a previously described Drosophila middle repeat found almost exclusively in the X euchromatin. It seems likely that these X linked sequences are required for sex chromosome specific functions.
Contemporary Clinical Profile and Outcome of Prosthetic Valve Endocarditis (2007)

Prosthetic valve endocarditis accounts for a high percentage of all cases of infective endocarditis in many regions of the world. Staphylococcus aureus is now the leading cause of PVE. Health care-associated infection significantly influences the clinical characteristics and outcome of PVE. Complications of PVE strongly predict in-hospital mortality, which remains high despite prompt diagnosis and the frequent use of surgical intervention.
Comprehensive Investigation on Fluorosilicate Glass Prepared by Temperature-Difference-Based Liquid-Phase Deposition (2000)

This study investigates the properties of fluorosilicate glass film prepared by temperature‐difference‐based liquid‐phase deposition. Experimental results indicate that the deposition temperature can significantly affect the deposition rate and film properties. As the deposition temperature increases from 15 to 35°C, the deposition rate increases exponentially from 30 to 687 Å/h. Meanwhile, the F and OH contents increase from 2.56 to 3.49% and from 0.16 to 0.5%, respectively. The dielectric constants and stresses for the films deposited at 15, 25, and 35°C, are 3.56/63 MPa, 3.46/43 MPa, and 3.66/73 MPa, respectively. The current densities at 20 MV/cm for the films deposited at 15, 25, and 35°C are , , and , respectively. For the film deposited at 25°C, the dielectric constant and the stress are minimal because of the high F content, low OH content, and low bond strain. The properties are also compared with those of fluorosilicate glass prepared by plasma‐enhanced chemical vapor deposition. In addition to exhibiting a lower dielectric constant and much better resistance to moisture, the film prepared by temperature‐difference‐based liquid‐phase deposition also shows a comparable or better insulating property, revealing a reliable intermetal dielectric with a low dielectric constant. © 2000 The Electrochemical Society. All rights reserved.
Role of Cytokines and Adhesion Molecules in Ischemia and Reperfusion in Patients With Acute Myocardial Infarction (1999)

Although acute myocardial infarction (AMI) may involve both plaque rupture and ischemia-reperfusion injury, the pathogenesis of these phenomena is unclear. To elucidate the pathogenesis of AMI, serial measurements of platelet activating factor (PAF), interleukin-6 and cell adhesion molecules were made in patients with AMI. The PAF levels were measured upon hospital admission and at 24 and 72h in 8 patients with AMI. Serum levels of interleukin-6, soluble E-selectin (sE-selectin), soluble intercellular adhesion molecule-1 and soluble vascular cell adhesion molecule- 1 (sVCAM- 1) were measured upon admission and at 24 h and 4 weeks in 30 patients with AMI and 15 patients with stable effort angina. PAF levels were higher in patients with AMI than in normal volunteers; the increased levels lasting at least 72h. In contrast, interleukin-6 increased at 24h. sE-selectin was elevated at admission and sVCAM-1 increased later. sE-selectin levels upon admission in patients with additional ST-segment elevation after reperfusion were significantly higher than those in patients without ST-elevation. In patients with AMI, the time-course of changes in blood levels of cytokines varied according to the individual substances. Although it is unclear what is the precise role of each of the cytokines in the pathophysiology of AMI, sE-selectin may be possibly related to the reperfusion injury in the infarcted myocardium.
Flexible Nanoporous Template for the Design and Development of Reusable Anti-COVID-19 Hydrophobic Face Masks (2020)

Since the outbreak of the severe respiratory disease caused by the novel coronavirus (COVID-19), the use of face masks has become ubiquitous worldwide to control the rapid spread of this pandemic. As a result, the world is currently facing a face mask shortage, and some countries have placed limits on the number of masks that can be bought by each person. Although the surgical grade N95 mask provides the highest level of protection currently available, its filtration efficiency for sub-300 nm particles is around 85% due to its wider pore size (∼300 nm). Because the COVID-19 virus shows a diameter of around 65-125 nm, there is a need for developing more efficient masks. To overcome these issues, we demonstrate the development of a flexible, nanoporous membrane to achieve a reusable N95 mask with a replaceable membrane and enhanced filtration efficiency. We first developed a flexible nanoporous Si-based template on a silicon-on-insulator wafer using KOH etching and then used the template as a hard mask during a reactive ion etching process to transfer the patterns onto a flexible and lightweight (<0.12 g) polymeric membrane. Pores with sizes down to 5 nm were achieved with a narrow distribution. Theoretical calculations show that airflow rates above 85 L/min are possible through the mask, which confirms its breathability over a wide range of pore sizes, densities, membrane thicknesses, and pressure drops. Finally, the membrane is intrinsically hydrophobic, which contributes to antifouling and self-cleaning as a result of droplets rolling and sliding on the inclined mask area.
DNA Transfer (1990)

The experimental introduction of DNA into cells is accomplished by methods that (1) form DNA precipitates that can be internalized by the target cell; (2) create DNA-containing complexes whose charge characteristics are compatible with DNA uptake by the target cell; or (3) result in the transient formation of pores in the plasma membrane of a cell exposed to an electric pulse, pores of sufficient size to allow DNA to enter the target cell.KeywordsComplete Growth MediumDEAE DextranElectroporation CuvetteElectroporation BufferConical Polypropylene TubeThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Professional writing: collective purpose (2001)

Adrienne Price discusses the need for group publication in health care and emphasises the importance of developing a publication strategy.
Video Description Using Bidirectional Recurrent Neural Networks (2016)

Although traditionally used in the machine translation field, the encoder-decoder framework has been recently applied for the generation of video and image descriptions. The combination of Convolutional and Recurrent Neural Networks in these models has proven to outperform the previous state of the art, obtaining more accurate video descriptions. In this work we propose pushing further this model by introducing two contributions into the encoding stage. First, producing richer image representations by combining object and location information from Convolutional Neural Networks and second, introducing Bidirectional Recurrent Neural Networks for capturing both forward and backward temporal relationships in the input frames.
27 mΩ-cm/sup 2/, 1.6 kV power DiMOSFETs in 4H-SiC (2003)

We report on the characteristics of large area (3.3 /spl times/ 3.3 mm/sup 2/) high voltage 4H-SiC DiMOSFETs. The MOSFETs show a peak MOS channel mobility of 22 cm/sup 2//V/spl middot/s and a threshold voltage of 8.5 V at room temperature. The DiMOSFETs exhibit an on-resistance of 27 m/spl Omega//spl middot/cm/sup 2/ at room temperature. The devices block approximately 1.6 kV at room temperature. Stable avalanche characteristics at approximately 2.4 kV are observed on smaller devices. An on-current of 20 A is measured on a 0.103 cm/sup 2/ device. High switching speed is also demonstrated. This suggests that the devices are ideal for high voltage, high frequency, low loss switching applications.
Leukemia regression by vascular disruption and antiangiogenic therapy (2010)

Acute myelogenous leukemias (AMLs) and endothelial cells depend on each other for survival and proliferation. Monotherapy antivascular strategies such as targeting vascular endothelial growth factor (VEGF) has limited efficacy in treating AML. Thus, in search of a multitarget antivascular treatment strategy for AML, we tested a novel vascular disrupting agent, OXi4503, alone and in combination with the anti-VEGF antibody, bevacizumab. Using xenotransplant animal models, OXi4503 treatment of human AML chloromas led to vascular disruption in leukemia cores that displayed increased leukemia cell apoptosis. However, viable rims of leukemia cells remained and were richly vascular with increased VEGF-A expression. To target this peripheral reactive angiogenesis, bevacizumab was combined with OXi4503 and abrogated viable vascular rims, thereby leading to enhanced leukemia regression. In a systemic model of primary human AML, OXi4503 regressed leukemia engraftment alone and in combination with bevacizumab. Differences in blood vessel density alone could not account for the observed regression, suggesting that OXi4503 also exhibited direct cytotoxic effects on leukemia cells. In vitro analyses confirmed this targeted effect, which was mediated by the production of reactive oxygen species and resulted in apoptosis. Together, these data show that OXi4503 alone is capable of regressing AML by a multitargeted mechanism and that the addition of bevacizumab mitigates reactive angiogenesis.
Orthogonal arrays of intramembranous particles: a review with special reference to astrocytes. (1995)

This review describes properties and occurrence of the so-called orthogonal arrays of intramembranous particles (OAPs). These peculiar components of membranes were described in astrocytes, intestinal cells, kidney collecting tubule cells, lens fiber cells, muscle cells and a number of other cell types in vertebrates. They are shown only by means of the freeze-fracture technique and are not understood functionally at present. They are suggested to play a role in ionic transport processes. They appear to represent proteins, but it is not known whether or not OAPs observed in different tissues are identical structures. In the central nervous system, they are confined to macroglial cell types such as astrocytes, retinal Müller cells, ependymal cells and tanycytes. Oligodendrocytes are devoid of them. Interrelations between OAPs and other membrane specializations such as tight junctions and caveolae are described. The most conspicuous property of astrocytic OAPs in situ is their unequal distribution. The resulting OAP-related polarity is lost in cultured astrocytes and therefore seems to require the intact microenvironment of the brain. The possible role of polarized astrocytes for the maintenance of the blood-brain barrier is discussed. In addition, the relationship between the capability of a nervous system to regenerate after injury and the occurrence of OAPs in astrocytes is considered.
Low-IMD Two-Tone Signal Generation for ADC Testing (2012)

This paper describes algorithms for generating low intermodulation-distortion (IMD) two-tone sine waves, for communication application ADC testing, using an arbitrary waveform generator (AWG) or a multi-bit Sigma-Delta DAC inside an SoC. The nonlinearity of the DAC generates distortion components, and we propose here eight methods to precompensate for the IMD using DSP algorithms and produce low-IMD two-tone signals. Theoretical analysis, simulation, and experimental results all demonstrate the effectiveness of our approach.
Pteridines. VI. Preparation of some 6-aryl-7-aminopteridines (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPteridines. VI. Preparation of some 6-aryl-7-aminopteridinesJoseph Weinstock, Roberta Y. Dunoff, Blaine Sutton, Barry Trost, Joel Kirkpatrick, Frank Farina, and Alice S. StraubCite this: J. Med. Chem. 1968, 11, 3, 549–556Publication Date (Print):May 1, 1968Publication History Published online1 May 2002Published inissue 1 May 1968https://pubs.acs.org/doi/10.1021/jm00309a030https://doi.org/10.1021/jm00309a030research-articleACS PublicationsRequest reuse permissionsArticle Views167Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Sequencing of BRAF inhibitors and ipilimumab in patients with metastatic melanoma: a possible algorithm for clinical use (2012)

Our analysis suggests it may be possible to identify those patients at high risk of rapid disease progression upon relapse with a BRAF inhibitor who might not have time to subsequently complete ipilimumab treatment. We hypothesise that these BRAF-mutation positive patients may benefit from being treated with ipilimumab first.