gebhart/patrepeval huggingface dataset:
Inhibition of rat cerebellar nitric oxide synthase by 7‐nitro indazole and related substituted indazoles (1993)

1. 7-Nitro indazole (7-NI) produces potent inhibition of rat cerebellar nitric oxide synthase (NOS) with an IC50 of 0.9 +/- 0.1 microM (n = 6). NOS activity is dependent on the presence of both exogenous CaCl2 and NADPH. The inhibitory potency of 7-NI remained unaltered in the presence of different concentrations of either CaCl2 (0.75-7.5 mM) or NADPH (0.05-5.0 mM). 2. Kinetic (Lineweaver-Burke) analysis of the effect of 7-NI on rat cerebellar NOS revealed that inhibition was of a competitive nature with a Ki value of 5.6 microM. The Km of of cerebellar NOS with respect to L-arginine was 2.5 microM. 3. The following indazole derivatives (IC50 values shown in parentheses, all n = 6) caused concentration-related inhibition of rat cerebellar NOS in vitro: 6-nitro indazole (31.6 +/- 3.4 microM), 5-nitro indazole (47.3 +/- 2.3 microM), 3-chloro indazole (100.0 +/- 5.5 microM), 3-chloro 5-nitro indazole (158.4 +/- 2.1 microM) and indazole (177.8 +/- 2.1 microM). The IC50 values for 5-amino indazole, 6-amino indazole and 6-sulphanilimido indazole were in excess of 1 mM; 3-indazolinone was inactive. 4. 7-NI (10 mg kg-1) administered i.p. to rats produced 60 min thereafter a significant inhibition of NOS activity in cerebellum (31.1 +/- 3.2%, n = 6), cerebral cortex (38.2 +/- 5.6%, n = 6), hippocampus (37.0 +/- 2.8%, n = 6) and adrenal gland (23.7 +/- 3.0%, n = 6). NOS activity in olfactory bulb and stomach fundus were unchanged. 5. These results indicate that 7-NI is a potent and competitive inhibitor of rat brain NOS in vitro and also inhibits NOS in different brain regions and in the adrenal gland in vivo. Inhibition of NOS is a characteristic property of the indazole nucleus. Nitration of the indazole ring at positions 5, 6 and 7 results in a graded increase in inhibitory potency. Indazole-based inhibitors of NOS may prove useful tools with which to evaluate the biological roles of nitric oxide in the central nervous system.
Encyclopedia of Applied High Energy and Particle Physics (2009)

1. Quantum Mechanics (J.Burgdorfer, S.Rotter) 2. Special Relativity (T.Takeuchi) 3. Strong Interaction (F.Karsch, W.Vogelsang) 4. The Standard Model of Elementary Particles (J.Erler) 5. Weak Interaction (K.-I.Hikasa) 6. Particle Physics (D.Green) 7. Applied String Theory (R.Schimmrigk) 8. Neutrino Astrophysics (W.C.Haxton) 9. Nuclear Structure (J.Jolie, J.P.Davidson) 10. Nuclear Reactions (C.A. Bertulani) 11. Radioactivity (W.Loveland) 12. Particle Impact Phenomena (N.Tolk, M.Albert, J.Gregory, A.Steigerwald, T.Wade) 13. Cyclotrons (G.H.Mackenzie, P.W.Schmor, H.R.Schneider) 14. Design and Application of Cyclotrons (R.A. Baartman, R.E. Laxdal, G.H. Mackenzie) 15. Electrostatic Accelerators (D.C.Weisser) 16. Linear Accelerators (R.Jameson, J.Bisognano, P.Lapostolle) 17. Free Electron Lasers (C.Pellegrini, S.Reiche) 18. Synchrotons and Storage Rings (O.Boine-Frankenheim, H.Kobayakawa) 19. Storage Rings (J.Rohlf) 20. Targets for Particle Accelerators (B.Kindler, B.Lommel) 21. Calorimeters in Particle Physics (Ch.Fabjan) 22. Semiconductor Tracking (E.Heijne) 23. Tracking in Particle Detectors (D.Rohrich, A.Acevski, T.C.Meyer) 24. Gamma-Ray Spectrometers (A.M.Sandorfi) 25. Managing the Extreme Dataflow of LHC (N.Neufeld, D.Liko)
High Strength Regenerated Cellulose Fibers (1959)

Substantial improvements in the physical strength properties of certain fibrous regenerated cellulose products, notably rayon tire cord, have been achieved during the past decade. These advances in tensile and fatigue properties of tire cord rayon are reviewed and the factors responsible for the improvements are discussed in such a manner as to point the way for similar quality gains in related products, such as staple fiber. Improvement in properties is primarily attributed to the combined use of physical and chemical actions to accomplish controlled crystallite development and orientation in the spinning filament. Beneficial use has been made of various types of chemical re generation retarding agents to prolong the plastic-gel state, thereby facilitating heavy stretching along with dehydration of the coagulated filament to yield a highly consoli dated and uniaxially oriented structure prior to complete regeneration. The relation of current spinning practices to mechanical properties attained in the final filament are outlined and interpreted in the light of filament cross-sectional struc ture, secondary swelling properties, and differential dyeing characteristics. Potential strength aims for future cellulosics are discussed and some suggestions made as to the type of products for which the structural skeleton of the cellulose polymer appears to offer outstanding advantages, particularly when coupled with bonding or stabilizing resins in intimate molecular association.
Renal excretion and pharmacokinetics of foscarnet in HIV sero-positive patients: effect of probenecid pretreatment (1997)

The study shows that foscarnet is not transported via the probenecid-sensitive organic acid secretory pathway in the proximal tubule; the renal elimination of foscarnet is via glomerular filtration.
Two-dimension full array high-speed ink-jet print head (2006)

An ink-jet print head in a structure, similar to a liquid crystal display, is suggested. It is based on a segment, containing a microink reservoir, feeding one or a few nozzles. The segment is autonomous and unlimitedly duplicable to form a large ink-jet print head. The microreservoirs are open to the atmospheric pressure, and pressure regulation in the nozzle is accomplished by capillary action. The microreservoirs are replenished by slow wiper smearing action. Experiments with a 57600 nozzle matrix print head showed good results for the design. Printing speed of ∼1000pagesmin, and even more, is achievable.
Membrane-bound Steel factor induces more persistent tyrosine kinase activation and longer life span of c-kit gene-encoded protein than its soluble form (1995)

Alternative splicing of exon 6 results in the production of two isoforms of Steel factor (SLF): the membrane-bound and soluble forms. To investigate differences in the kinetics of c-kit tyrosine kinase activated by these two isoforms, we used a stromal cell line (SI/SI4) established from SI/SI homozygous murine embryo fetal liver and its stable transfectants containing either hSCF248 cDNA (including exon 6; secreted form) or hSCF220 cDNA (lacking exon 6; membrane-bound form) as the source of each isoform. Interaction of factor dependent myeloid cell line MO7e with stromal cells producing either isoform resulted in activated c-kit tyrosine kinase and induction of the same series of tyrosine phosphorylated cellular proteins in MO7e cells. However, SI4-h220 (membrane-bound form) induced more persistent activation of c-kit kinase than SI4-h248 (soluble form) did. Flow cytometric analysis and pulse-chase studies using [35S]methionine showed that SI4-h248 induced rapid downmodulation of cell-surface c-kit expression and its protein degradation in MO7e cells, whereas SI4-h220 induced more prolonged life span of c-kit protein. Addition of soluble recombinant human SLF to SI4-h220 cultures enhanced reduction of cell-surface c-kit expression and its protein degradation. Because the kinetics of c-kit inactivation strikingly fits with the protein degradation rates of c-kit under the conditions described above, rapid proteolysis of c-kit protein induced by soluble SLF stimulation may function as a "turn-off switch" for activated c-kit kinase.
Endothelium Dependent Vasorelaxant Effect of Aqueous Extract of Polygoni Cuspidatae Radix on Arterial Contraction in Rabbit (2008)

This study was undertaken to define the effect of Polygoni cuspidatae Radix on contracted rabbit common carotid artery and its mechanism. In order to investigate the effect of Polygoni cuspidatae Radix on rabbit's contracted vascular ring detached from common carotid artery, vascular ring with intact or damaged endothelium was used for the experiment using organ bath. To analyze the mechanism of Polygoni cuspidatae Radix-induced relaxation, Polygoni cuspidatae Radix extract was infused into contracted vascular ring which had been pretreated by Nω -nitro-L-arginine(L-NNA), Methylene blue(MB), and Ca 2+ was infused into contracted vascular ring induced by NE or KCl after treatment of Polygoni cuspidatae Radix extract in Ca 2+ -free solution. The results were as follows : Polygini cuspidatae Radix had an effective relaxation to the contracted vascular ring by NE in 0.1 mg/ml and 0.3 mg/ml level. Polygini cuspidatae Radix had an effective relaxation to the intact endothelium vascular ring, but when endothelium was removed, vascular ring did not relax. Polygini cuspidatae Radix-induced relaxation was inhibited by the pretreatment of L-NNA and MB. Pretreatment of Polygini cuspidatae Radix extract inhibit the contraction by influx of extra-Ca 2+ in contracted vascular ring induced by NE or KCl in Ca 2+ -free solution. As mentioned above, we suggest that Polygini cuspidatae Radix relaxes vascular ring through suppress influx of extra-cellular Ca 2+ by the action of nitric oxide from endothelium.
New adsorbents for purification: Selective removal of aromatics (2002)

Abstract Adsorption of benzene and cyclohexane on various Y‐zeolites was investigated to develop sorbents for the purification of aliphatics by removal of aromatics. Ag‐Y showed superior benzene/cyclohexane selectivities to Na‐Y, Pd‐Y, and H‐USY. Separation factors greater than 10 5 were obtained with Ag‐Y at low concentrations of benzene. High selectivities were achieved by the strong interaction between benzene and Ag‐Y, while the interaction with cyclohexane was not influenced by the cations. Molecular orbital calculation revealed that benzene formed a classic π‐complexation bond with Ag‐Y: donation of electron charges from the p‐orbitals of benzene to the vacant s‐orbital of the silver (σ donation) and, simultaneously, back donation of electron charges from d‐orbitals of silver to π*‐orbital of benzene (d–π* back donation). Grand canonical Monte Carlo simulations were also performed for adsorption isotherms. Potential parameters of benzene on Ag‐Y, including π‐complexation, were developed first. Simulation and experiments of GCMC agreed excellently for adsorption of benzene on Y‐zeolites.
Industrial Progress: New Energy-Efficient Absorbents for the CO&lt;sub&gt;2&lt;/sub&gt; Separation from Natural Gas, Syngas and Flue Gas (2011)

The CO2 separation from natural gas, syngas or flue gas represents an important industrial field of applications. An economic and energy-efficient CO2 separation from these gas streams is a prerequisite for sustainable industry contributions to the megatrends resource efficiency and globalization of technologies. One way of reducing operational expenditure for these separation processes is the development of better performing CO2 absorbents. Although a number of absorbents for the separation of CO2 from process gas streams exist, the need for the development of CO2 absorbents with an improved absorption performance, less corrosion and foaming, no nitrosamine formation, lower energy requirement and therefore less operational expenditure remains. Recent industrial activities have led to the development of novel high-performance CO2 scrubbing agents that can be employed in numerous industrial processes such as natural gas treatment, purification of syngas and the scrubbing of flue gas. The objective of this paper is to introduce these new high-performance scrubbing agents and to compare their performance with other state-of-the-art absorbents. It turned out, that the evaluated absorbents offer high cyclic capacities in the range of 2.4 to 2.6 mol CO2/kg absorbent and low absorption enthalpies (–30 kJ/mol) allowing for distinctive savings in the regeneration energy of the absorbent. Calculations with the modified Kremser model resulted in a reduction of the specific reboiler heat duty of 55%. Furthermore, the absorbents are less corrosive than standard amines as indicated by the measured corrosion rates of 0.21 mm/y versus 1.18 mm/y for a piperazine/methyldiethanolamine mixture. Based on new experimental results it is shown how substantial savings in operational and capital expenditure can be realized due to favorable absorbent properties. The novel high-performance CO2 system solutions meet recent industrial absorbent requirements and allow for more efficient or new CO2 separation processes.
Behavioral clusters and coronary heart disease risk. (1992)

The purpose of the present study was to empirically identify individuals who differed in their patterns of components derived from the structured interview (SI), and to evaluate whether individuals characterized by the different patterns varied in terms of their risk for coronary heart disease (CHD). The present study represents a reanalysis of data from the Western Collaborative Group Study in which components of Type A were individually related to risk for CHD. Subgroups of individuals who differed in the patterns of their component scores were identified by means of cluster analytic techniques and were found to vary in their risk of CHD. As expected, a pattern of characteristics in which hostility was salient was found to be predictive of CHD. Moreover, another pattern of characteristics that appears to reflect pressured, controlling, socially dominant behavior in which hostility was not salient also was found to be predictive of CHD. Further, two patterns of characteristics were identified that were unrelated to CHD risk. Finally, two patterns of characteristics were identified that were related to reduced risk of CHD. Overall, these results suggest that future research should investigate variables in addition to hostility in regard to risk for and protection from CHD.
Development of portable SPR sensor devices based on integrated periodic arrays of nanoholes (2009)

Periodic arrays of nanoholes are being developed by several groups for integrated and portable real-time sensing based on surface plasmon resonance (SPR). Recent advances have allowed for nanohole sensitivity comparable to ATR SPR. Here, we will present our new advances in developing integrated and multiplexed SPR sensors using nanohole arrays. For the first time, we will present our dual-wavelength approaches that remove the need for a spectrometer, thus greatly reducing cost and size. We will also present our recent achievements in (1) in-hole sensing, demonstrating attomolar detection, and (2) flow-through sensing, where the detection time is greatly reduced due to the rapid diffusion inside the nanoholes themselves.
The Kinetics of the Thermal Decomposition of Sodium Nitrate and of the Reaction between Sodium Nitrite and Oxygen (1956)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Kinetics of the Thermal Decomposition of Sodium Nitrate and of the Reaction between Sodium Nitrite and OxygenEli S. FreemanCite this: J. Phys. Chem. 1956, 60, 11, 1487–1493Publication Date (Print):November 1, 1956Publication History Published online1 May 2002Published inissue 1 November 1956https://pubs.acs.org/doi/10.1021/j150545a005https://doi.org/10.1021/j150545a005research-articleACS PublicationsRequest reuse permissionsArticle Views2061Altmetric-Citations111LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
The design of activity-oriented social networking (2011)

In this paper we present the system design and rational for a novel activity-oriented social networking site called Dig-Event. This system extends our previous work on event based consumer mashups and is inspired by research on popular social network applications. Dig-Event provides an open, social space for users to share events and discover the activity of mutual interest among social contacts like schoolmates, families, friends and colleagues. It allows users to share their activities to the customized social circle, conduct events by selecting activity-based gadgets, and socialize around them. The features of event recommendation and integration with existing social networks further boost the event socialization experience.
Optimised Conditions for the Production of Hepatitis B Virus from Cell Culture (2001)

In chronically infected patients, hepatitis B virus (HBV) particles reach numbers as large as >10(9) genome equivalents (GE)/ml of serum. However, expression of infectious HBV particles in cell culture only yields 10(5)-10(6) GE/ml, which is insufficient for many studies. HBV transcription and possibly replication is dependent on hepatocyte-specific differentiation. Thus, we tested several cell culture parameters that have been reported to enhance the expression of hepatocyte-specific markers, such as growth on different extracellular matrices, different cell culture media, low concentrations of fetal calf serum (FCS) and the addition of dimethyl sulfoxide (DMSO) to the medium. Lower concentrations of FCS, growth on collagen and inclusion of DMSO in the medium only moderately enhanced HBV production in vitro when applied individually. However, combinations of these parameters optimised cell culture conditions and reproducibly increased the release of HBV particles about 100-fold to titres >10(8) GE/ml of culture medium.
Compact SOI-based polarization diversity wavelength de-multiplexer circuit using two symmetric AWGs (2012)

We demonstrate a compact 16-channel 200 GHz polarization diversity wavelength de-multiplexer circuit using two silicon AWGs and 2D grating couplers. Estimated fiber to fiber loss is better than -15.0 dB. Insertion loss and crosstalk induced by the AWGs are -2.6 dB and 21.5 dB, respectively. The maximum polarization dependent wavelength shift is 0.12 nm. The polarization dependent loss varies between 0.06 dB and 2.32 dB over the 16 channels. The total circuit footprint is 1400 × 850 μm(2).
Signal-to-noise and radiation exposure considerations in conventional and diffraction x-ray microscopy (2009)

Using a signal-to-noise ratio estimation based on correlations between multiple simulated images, we compare the dose efficiency of two soft x-ray imaging systems: incoherent brightfield imaging using zone plate optics in a transmission x-ray microscope (TXM), and x-ray diffraction microscopy (XDM) where an image is reconstructed from the far-field coherent diffraction pattern. In XDM one must computationally phase weak diffraction signals; in TXM one suffers signal losses due to the finite numerical aperture and efficiency of the optics. In simulations with objects representing isolated cells such as yeast, we find that XDM has the potential for delivering equivalent resolution images using fewer photons. This can be an important advantage for studying radiation-sensitive biological and soft matter specimens.
A survey of dairy herd rations in aberdeenshire (1972)

Abstract Feeding régimes and feed analyses are reported for 55 dairy farms in Aberdeenshire during the winter of 1969–70. An assessment of the rations suggests that the most serious nutrient deficiency was in the energy supply to high‐yielding cows. Phosphorus intakes were also low, particularly of low‐yielding cows. The incidence of other nutrient deficiencies is discussed. On many farms proprietary mineral supplements, used at the recommended rates, were inadequate for correction of apparent mineral deficiencies.
Rate-adaptive tasks: model, analysis, and design issues (2014)

In automotive systems, some of the engine control tasks are triggered by specific crankshaft rotation angles and are designed to adapt their functionality based on the angular velocity of the engine. This paper proposes a new task model for specifying such a type of real-time activities and presents an approach for analyzing the system feasibility under deadline scheduling for different scenarios. In particular, a feasibility test is derived for tasks under steady-state conditions (constant speed), as well as in dynamic conditions (constant acceleration). A design method is also discussed to determine the most suitable switching speeds for adapting the functionality of tasks without exceeding a desired utilization. Finally, a number of research directions are highlighted to extend the current results to more complex and realistic scenarios.
24. How Companies Learn Your Secrets (2013)

Pole has a master’s degree in statistics and another in economics, and has been obsessed with the intersection of data and human behavior most of his life. His parents were teachers in North Dakota, and while other kids were going to 4-H, Pole was doing algebra and writing computer programs. “The stereotype of a math nerd is true,” he told me when I spoke with him last year. “I kind of like going out and evangelizing analytics.”
Binding of Murine Leukemia Virus Gag Polyproteins to KIF4, a Microtubule-Based Motor Protein (1998)

A cDNA clone encoding a cellular protein that interacts with murine leukemia virus (MuLV) Gag proteins was isolated from a T-cell lymphoma library. The sequence of the clone is identical to the C terminus of a cellular protein, KIF4, a microtubule-associated motor protein that belongs to the kinesin superfamily. KIF4-MuLV Gag associations have been detected in vitro and in vivo in mammalian cells. We suggest that KIF4 could be involved in Gag polyprotein translocation from the cytoplasm to the cell membrane.
Graduate Music Education. (2008)

This essay on graduate music education is in response to an article by David Hebert on challenges and solutions in online music teacher education that appeared in the online journal, Research and Issues in Music Education, 5(1). I found the article stimulating because so little has been written on the topic of music teacher education at the graduate level.\nIt appears that graduate music education in institutions of higher learning is locked into traditions that online programs are ready to challenge. In this essay I consider this challenge from a traditionalist viewpoint to determine if an online approach is a feasible option to music education at the doctorate and master's levels. Specifically, I seek to determine what the nature of graduate degrees in music education are or should be, if online and traditional curricula are in agreement in fulfilling these requirements, and if some variant or compromise is appropriate in developing music teachers at the graduate level.