gebhart/patrepeval huggingface dataset:
Design and Implementation of FPGA-based Systolic Array for LZ Data Compression (2010)

In this chapter, a parallel algorithm for LZ based data compression is described by transforming a data­dependent algorithm to a data ­ independent regular algorithm. To further improve the latency, a control variable to indicate early completion is used. The
The Notch1 transcriptional activation domain is required for development and reveals a novel role for Notch1 signaling in fetal hematopoietic stem cells (2014)

Notch1 is required to generate the earliest embryonic hematopoietic stem cells (HSCs); however since Notch-deficient embryos die early in gestation, additional functions for Notch in embryonic HSC biology have not been described. We used two complementary genetic models to address this important biological question. Unlike Notch1-deficient mice, mice lacking the conserved Notch1 transcriptional activation domain (TAD) show attenuated Notch1 function in vivo and survive until late gestation, succumbing to multiple cardiac abnormalities. Notch1 TAD-deficient HSCs emerge and successfully migrate to the fetal liver but are decreased in frequency by embryonic day 14.5. In addition, TAD-deficient fetal liver HSCs fail to compete with wild-type HSCs in bone marrow transplant experiments. This phenotype is independently recapitulated by conditional knockout of Rbpj, a core Notch pathway component. In vitro analysis of Notch1 TAD-deficient cells shows that the Notch1 TAD is important to properly assemble the Notch1/Rbpj/Maml trimolecular transcription complex. Together, these studies reveal an essential role for the Notch1 TAD in fetal development and identify important cell-autonomous functions for Notch1 signaling in fetal HSC homeostasis.
Experimental radioimmunotargeting combining nonlabeled, iodine-125-labeled, and anti-idiotypic anticytokeratin monoclonal antibodies (1997)

This study confirms an extensive accumulation of TS1 in the tumor, with peak values as late as 30 days after injection of labeled TS1. Furthermore, both preinjection of nonlabeled TS1 and postinjection of alphaTS1 can improve radioimmunotargeting.
Tau levels do not influence human ALS or motor neuron degeneration in the <i> SOD1 <sup>G93A</sup> </i> mouse (2010)

These findings suggest that the H1/H2 polymorphism in MAPT is not associated with human amyotrophic lateral sclerosis, and that lowering tau levels in the mutant SOD1 mouse does not affect the motor neuron degeneration in these animals.
In vitro evidence that carbohydrate moieties derived from uromodulin, an 85,000 dalton immunosuppressive glycoprotein isolated from human pregnancy urine, are immunosuppressive in the absence of intact protein. (1987)

Our laboratory recently reported the purification of a unique immunosuppressive glycoprotein isolated from human pregnancy urine (7). This glycoprotein, which we term uromodulin, has a m.w. of 85,000 as assessed on SDS-PAGE and is 30% carbohydrate. Uromodulin blocks in vitro antigen-specific T cell proliferation to recall antigens such as tetanus toxoid at concentrations as low as 100 pM. This glycoprotein also blocks the in vitro generation of spontaneous monocyte-mediated cytotoxicity (7, 36). Recent evidence strongly suggests that the primary action of uromodulin is to act as a specific ligand and modulator of IL 1 (10, 33). We now report additional biochemical characterization of uromodulin, and based on three independent lines of evidence, find that its immunologic activity appears to result from its glycosylation. First, measures to alter the tertiary folding of the protein backbone of uromodulin, including succinylation or reduction and carboxymethylation, fail to significantly affect its in vitro bioactivity. Second, after extensive digestion of intact uromodulin with pronase, the majority of the in vitro bioactivity can be recovered in a single carbohydrate-rich fraction. Finally, digestion with N-glycanase (N-glycosidase F-, an enzyme specific for N-asparagine-linked oligosaccharides) and subsequent purification on thin layer chromatography yields a single complex oligosaccharide that appears to be responsible for the majority of the in vitro immunosuppression mediated by uromodulin. These data suggest that uromodulin displays N-linked carbohydrate sequences capable of down-regulating antigen-specific T cell responses in vitro. It has been suggested that endogenous lectins may play an important role as recognition molecules in mammalian, as well as more primitive immune systems (23, 24). Our in vitro biologic data strongly suggest that the carbohydrate portion of uromodulin is an excellent candidate to function as a potential lectin receptor.
A Detailed Investigation of the Polarization-Dependent Surface-Relief-Grating Formation Process on Azo Polymer Films (1999)

We have carried out two-beam interference experiments to form surface-relief gratings (SRGs) on azo polymer films under different polarization combinations. The mechanism of SRG formation on azobenzene chromophore functionalized polymer films has been shown to depend on both the spatial variation of the intensity as well as the polarization state of the incident field pattern. The treatment presented in this paper clearly defines the intensity and polarization distribution across the two-beam interference region for different polarization configurations of the interfering beams. The efficient photoisomerization process due to the spatial variation of the optical field renders the material anisotropic and the surface mobile. The simultaneous presence of a component of electric field gradient in the grating vector direction results in large-modulation-depth SRGs. We have carried out this investigation in one class of prototypical amorphous epoxy-based azo polymer thin films. Our results confirm that efficient SRG formation on azo functionalized polymer film requires photoinduced anisotropy and a component of optical field gradient in the direction of the grating vector.
Granite Rocks and the State's Influence Over Federal Land Use (1987)

22 p. ; 28 cm
Diamond wafer for SAW application (2002)

A three inch wafer of polycrystalline diamond on silicon has been successfully developed. High uniformity of quality of diamond and almost defect free diamond surface associated with high quality ZnO exhibit wonderful performance of diamond SAW devices. It was also observed that this material system has super high power handling capability, smaller temperature deviation compared with 36 Y cut and ST cut quartz, low phase slope characteristics in the passband, and extremely high breakdown voltage. A variety of applications are expected with the material system utilizing these features.
Further Novel Milbemycin Antibiotics from Streptomyces sp. E225. Fermentation, Isolation and Structure Elucidation. (1996)

Ten novel alpha and beta class milbemycins have been isolated and characterized from the Streptomyces sp. E225, which has previously been shown to produce four related milbemycins. Some of the metabolites contain new structural features including, VM48641 which possesses an alpha-methoxyl substituent at C-27, and VM48642 which contains a furan ring at the terminus of the C-26 side chain. Several of these new compounds were shown to possess potent anthelmintic activity. An analysis of NMR chemical shift trends in this series of metabolites is presented.
Automated Inspection of Railway Tunnels’ Power Line Using LiDAR Point Clouds (2019)

Transport networks need periodic inspections to increase their safety and improve their management. In the last few years, LiDAR (light detection and ranging) technology has become a tool for helping to create a precise database of almost any type of infrastructure. Mobile laser scanning (MLS) systems use a laser beam to collect dense three dimensional (3D) point clouds, which include geometric and radiometric data of the environment in which they are placed. In the context of this paper, a methodology for automatically inspecting the clearance gauge and the deflection of the aerial contact line in railway tunnels is presented. The main objective is to compare results and verify their compliance with the Spanish norm. The 3D data are provided by a LYNX Mobile Mapper System (MMS). First, the area is surveyed and then the obtained (3D) point cloud is classified into contact wire, suspension wire, and remaining points. Finally, the inspection of the railway’s power line is performed. The validation of the proposed methodology has been carried out in three different tunnel point clouds, obtaining both qualitative and quantitative results for points’ classification, together with the results of the measures performed.
Monolithic Low-Noise Amplifiers up to 10 GHz in Silicon and SiGe Bipolar Technologies (2000)

The noise properties of silicon and SiGe bipolar technologies at identical design rules are evaluated by theory and by experimental LNAs designed for the frequencies of 2 GHz, 6 GHz, and 10 GHz. For a fair comparison the same circuit principle is used for all six LNAs, with gain of about 20 dB or above, suitable for the applications in wireless communications.
An Augmented Reality museum guide (2008)

Recent years have seen advances in many enabling augmented reality technologies. Furthermore, much research has been carried out on how augmented reality can be used to enhance existing applications. This paper describes our experiences with an AR-museum guide that combines some of the latest technologies. Amongst other technologies, markerless tracking, hybrid tracking, and an ultra-mobile-PC were used. Like existing audio guides, the AR-guide can be used by any museum visitor, during a six-month exhibition on Islamic art. We provide a detailed description of the museumpsilas motivation for using AR, of our experiences in developing the system, and the initial results of user surveys. Taking this information into account, we can derive possible system improvements.
Progressive Accumulation of Toxic Metabolite in a Genetic Leukodystrophy (1984)

Progressive accumulation of a cytotoxic metabolite, galactosylsphingosine (psychosine), was found in the brain of the twitcher mouse, a mutant caused by genetic deficiency of galactosylceramidase. Similar abnormal accumulation was also found in the brain of the genetic galactosylceramidase deficiency disease in the dog and in human patients (globoid cell leukodystrophy or Krabbe disease). Galactosylphingosine was absent in the brains of normal and heterozygous mice. The finding provides support for the psychosine hypothesis as the biochemical pathogenetic mechanism of globoid cell leukodystrophy. Analogous mechanisms may be important in the pathogenesis of other genetic lysosomal diseases.
Scheduling and processor allocation for parallel execution of multijoin queries (2003)

The authors deal with two major issues to exploit inter-operator parallelism within a multijoin query: join sequence scheduling and processor allocation. For the first issue, they propose and evaluate by simulation several methods to determine the general join sequences, or the bush execution trees. Despite their simplicity, the proposed heuristics can lead to the general join sequences which significantly outperform the optimal sequential join sequence. In addition, several heuristics to determine the processor allocation, categorized by bottom-up and top-down approaches, were derived and evaluated by simulation. As confirmed by the simulation, by first using the join sequence heuristics to build a busy tree and then applying the concept of synchronous execution time to the busy tree for processor allocation, an efficient two-step approach to schedule and execute multijoin queries in a multiprocessor system can be obtained.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A single-layer perceptron for Fourier transform (2003)

Summary form only given, as follows. A single-layer perceptron has been trained to perform the fast Fourier transform. Excellent performance has been found through computer simulations. The peak amplitude of the filter sidelobes can be reduced significantly relative to the peak amplitude of the mainlobe, but the width of the mainlobe does not increase at all. Computer simulations show that the peak amplitude of the first sidelobe is zero for several cases. The single-layer perceptron finishes computation in two stages regardless of the number of samples in the time domain; this implies that the computation speed is fast. From simulation results it has been found that the number of neurons in the hidden layer determines the accuracy of output. More neurons in the hidden layers do not imply better performance. The number of neurons in the hidden layer can be as small as log n/log 2, where n is the number of input signal samples. This implies that the hardware implementation for real-time application is feasible. Results from a preliminary study show that the single-layer perceptron can suppress spectral leakage better than the blackman window, without widening the mainlobe, even with several faulty weights. The backpropagation training algorithm has been used to train the single-layer perceptron with specially designed data.
Synthesis of fluorescent organic phosphates and their equilibrium binding to bovine oxyhemoglobin (1975)

Fluorescent organic phosphates, beta-naphthyl diphosphate, beta-naphthyl triphosphate, and beta-naphthyl tetraphosphate, were synthesized from beta-naphthyl monophosphate using Pi and N,N'-dicyclohexylcarbodiimide. These organic phosphates were interacted with bovine oxyhemoglobin, all in no buffer, 0.1 M NaCl, at 25 degrees and in the pH range 5.5-7.0. Equilibrium binding parameters were determined by measuring the fluorescence quenching upon their interaction. It is indicated that bovine oxyhemoglobin has more than one binding site, one of which is very strong. The strength of binding to the stronger site is in the order beta-naphthyl tetraphosphate greater than beta-naphthyl triphosphate greater than beta-naphthyl diphosphate. The logarithms of association constants of these phosphates depend linearly on the net charges of these phosphates at any pH. The results were accounted for by electrostatic effects using a simple charge model. In that model, the average positive net charges in oxyhemoglobin involved in the binding of beta-naphthyl phosphate are shown as a function of pH. It is shown that the binding of these fluorescent organic phosphates is prevented reversibly by the excess addition of nonfluorescent organic and iorganic phosphates, inositol hexaphosphate, tripolyphosphate, and pyrophosphate. Assuming competitive binding in a single strong site, the association constants of these nonfluorescent phosphates were also determined by measuring the recovery of the fluorescence intensity upon the release of fluorescent phosphates. At pH 6.18, the association constant of pyrophosphate is lower than that of tripolyphosphate by one order.
EFFECT OF SERUM ON HUMAN BONE MARROW STROMAL CELLS: EX VIVO EXPANSION AND IN VIVO BONE FORMATION (2000)

Our data demonstrate that for ex vivo expansion of human BMSCs, medium with FBS remains most effective. However, incubation of human BMSCs in SFM prior to in vivo transplantation significantly stimulates subsequent bone formation. This finding increases the practicality of using culture-expanded BMSCs for autologous human transplantation and suggests the presence of osteogenic inhibitors in serum.
Isolation and characterization of the gene encoding the heavy chain of Drosophila kinesin. (1988)

An antiserum that recognizes the heavy chain of Drosophila kinesin was used to isolate Drosophila cDNA clones. Immunoblot analysis of the proteolytic fragments of the protein produced by one of the cDNA clones has demonstrated that the cDNA clones encode the heavy chain of Drosophila kinesin. The in vitro-synthesized product of the largest cDNA comigrates with Drosophila kinesin heavy chain on NaDodSO4/polyacrylamide gels and binds to taxol-stabilized microtubules in the presence of the nonhydrolyzable analogue of ATP, 5'-adenylyl imidodiphosphate, but not in the presence of ATP or 0.1 M KCl. Analysis of the cDNA clones suggests that there is a single gene encoding kinesin heavy chain in Drosophila located at polytene chromosome position 53A. However, Southern hybridization analyses suggest the presence of related sequences in the Drosophila genome.
Morphology and properties of segmented polyether polyurethaneureas (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMorphology and properties of segmented polyether polyurethaneureasCarl B. Wang and S. L. CooperCite this: Macromolecules 1983, 16, 5, 775–786Publication Date (Print):May 1, 1983Publication History Published online1 May 2002Published inissue 1 May 1983https://pubs.acs.org/doi/10.1021/ma00239a014https://doi.org/10.1021/ma00239a014research-articleACS PublicationsRequest reuse permissionsArticle Views1493Altmetric-Citations452LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A High-Performance CLYC(Ce)-PVT Composite for Neutron and Gamma Detection (2017)

In this paper, we fabricated and characterized a 50 mm diameter × 30 mm composite detector comprised of 9-mm diameter Cs <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sup> LiYCl <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sub> (Ce) [CLYC(Ce)] rods embedded in scintillating polyvinyltoluene (PVT). The CLYC(Ce) rods contributed to 42% of the total weight and 18.5% of the total composite volume. The scintillation performance of the CLYC(Ce)-PVT composite detector matched that of a stand-alone CLYC(Ce) crystal, with an energy resolution of 4.4% and a light yield of 18 100 ph/MeV at 662 keV. Furthermore, the composite showed excellent pulse shape discrimination, with a figure of merit of 3.2. This composite is useful for both spectroscopic and counting applications, the latter being facilitated by the high sensitivity of the scintillating polyvinytoluene. This paper demonstrates that composites offer an affordable route to large detector sizes (e.g., larger than 3-in diameter) and geometries (e.g., panels) beyond those achievable through standard crystal growth techniques.
Selective inhibition of cell proliferation and BCR-ABL phosphorylation in acute lymphoblastic leukemia cells expressing Mr 190,000 BCR-ABL protein by a tyrosine kinase inhibitor (CGP-57148). (1998)

The excessive proliferation of the myeloid marrow compartment in Philadelphia chromosome (Ph)-positive acute and chronic leukemias has been largely attributed to a hyperactive and autonomously acting hybrid tyrosine kinase BCR-ABL, a product of the fusion between the second exon of the c-ABL proto-oncogene and 5' portions of the BCR gene on chromosome 22. This specific molecular event, amenable to attack with specifically designed inhibitors, has recently been successfully influenced by the drug CGP-57148 in mammalian cells transfected with full-length BCR-ABL gene and expressing full-length p210Bcr-Abl protein, as well as in primary human leukemic cells expressing p210Bcr-Abl fusion protein. In view of the heterogeneity of BCR-ABL transcripts associated with various phenotypes, we investigated the effect of CGP-57148 on p190Bcr-Abl- and p210Bcr-Abl-expressing, patient-derived cell lines and primary intact blast cells. In particular, we were interested in whether the variations in molecular events and/or the phenotype of Ph-positive cells would affect their susceptibility to the specific tyrosine kinase inhibitor CGP-57148. We have demonstrated that the sensitivity of human cells with lymphoblastic immunophenotype expressing p190Bcr-Abl protein is comparable to that for leukemic myeloid cells expressing p210Bcr-Abl protein. After documenting profound and phenotype-independent suppression of both autophosphorylation and cell growth, we explored the importance of time and dose of exposure on the manifestation and stability of the induced events. Although there were variations between target cells, in vitro exposure for 24-48 h induced extensive and apparently irreversible apoptosis in BCR-ABL-expressing but not other normal or BCR-ABL-negative leukemic cells. These findings support the potential use of CGP-57148 to purge Ph-positive cells from autologous bone marrow in vitro. Another important finding was the comparable suppressive effect of temporary CGP-57148 exposure on both clonogenic KBM-5 cells and the whole cell population. Exposure time and dose appeared to be important variables among various cell types. Moreover, effective doses appeared uniformly harmless to cells lacking BCR-ABL protein functioning as tyrosine kinase. Thus, the continuous exposure of target cells, at least during the initial period of 24-48 h, may prove to be an important variable in the design of in vitro and in vivo therapy using tyrosine kinase inhibitors.
MEASURING EMERGING STOCK MARKET CORRELATIONS UTILIZING THE GRAVITY MODEL (2006)

Gravity models have been employed in determining international trade patterns among countries. In these models, geographical and cultural variables are found to be crucial factors of economic relations. This particular study suggests that application of gravity modeling also is useful for the explanation of stock market correlations. This study uses panel data to examine the effect of geographical, cultural, market size and economic variables on the stock market correlations in emerging markets. Empirical analysis found that distance, market size and legal system similarities have a profound impact on stock market correlations. This knowledge is an important prerequisite for the risk reduction.