gebhart/patrepeval huggingface dataset:
Using spreadsheets to develop applied skills in a business math course: Student feedback and perceived learning (2015)

This paper describes the redesign of a business math course and its delivery in both face-to-face and online formats. Central to the redesigned course was the addition of applied spreadsheet exercises that served as both learning and summative assessment tools. Several other learning activities and assignments were integrated in the course to address diverse student learning styles and levels of math anxiety. Students were invited to complete a survey that asked them to rank course activities and assignments based on how well they helped the student learn course material. Open-ended items were also included in the survey. In the online course sections, students reported higher perceived learning from the use the spreadsheet-based application assignments, while face-to-face students preferred demonstrations. Qualitative remarks from the online students included numerous comments about the positive learning impact of the business application spreadsheet-based assignments, as well as the link between these assignments and what students considered the âreal world.â
Intraorganelle localization and substrate specificities of the mitochondrial acyl‐CoA:<i>sn</i>‐glycerol‐3‐phosphate <i>O</i>‐acyltransferase and acyl‐CoA:1‐acyl‐<i>sn</i>‐glycerol‐3‐phosphate <i>O</i>‐acyltransferase from potato tubers and pea leaves (1990)

The mitochondrial sn-glycerol-3-phosphate and 1-acyl-sn-glycerol-3-phosphate O-acyltransferases from potato tubers and pea leaves were investigated with respect to their intraorganelle localization, their positional and substrate specificities, and their fatty acid selectivities. In mitochondria from potato tubers both enzymes were found to be located in the outer membrane. The 1-acyl-sn-glycerol-3-phosphate O-acyltransferase of pea mitochondria showed the same intraorganelle localization whereas the sn-glycerol-3-phosphate O-acyltransferase behaved like a soluble protein of the intermembrane space. The sn-glycerol-3-phosphate O-acyltransferase of both potato and pea mitochondria used sn-glycerol-3-phosphate but not dihydroxyacetone phosphate as acyl acceptor and exclusively catalyzed the formation of 1-acyl-sn-glycerol-3-phosphate which subsequently served as substrate for the second acylation reaction at its C-2 position. Both acyltransferases of potato as well as pea mitochondria showed higher activities with acyl-CoA than with the corresponding acyl-(acyl carrier protein) thioesters. When different acyl-CoA thioesters were offered separately, the sn-glycerol-3-phosphate O-acyltransferase of potato mitochondria displayed no fatty acid specificity whereas the enzyme of pea mitochondria revealed one for saturated acyl groups. On the other hand, the mitochondrial 1-acyl-sn-glycerol-3-phosphate O-acyltransferases from both potato tubers and pea leaves were more active on unsaturated than on saturated acyl-CoA thioesters. Furthermore, these enzymes preferentially used oleoyl- and linoleoyl-CoA when they were offered in a mixture with saturated ones, although the fatty acid selectivity of the pea enzyme was less pronounced than that of the potato enzyme. The sn-glycerol-3-phosphate O-acyltransferase of potato mitochondria displayed a slight preference for saturated acyl groups.
Antitumor Activity of a Humanized, Bivalent Immunotoxin Targeting Fn14-Positive Solid Tumors (2013)

The TNF-like weak inducer of apoptosis (TWEAK; TNFSF12) receptor Fn14 (TNFRSF12A) is expressed at low levels in normal tissues but frequently highly expressed in a wide range of tumor types such as lung, melanoma, and breast, and therefore it is a potentially unique therapeutic target for these diverse tumor types. We have generated a recombinant protein containing a humanized, dimeric single-chain anti-fibroblast growth factor-inducible 14-kDa protein (Fn14) antibody fused to recombinant gelonin toxin as a potential therapeutic agent (designated hSGZ). The hSGZ immunotoxin is a highly potent and selective agent that kills Fn14-positive (Fn14(+)) tumor cells in vitro. Treatment of cells expressing the MDR protein MDR1 (ABCB1B) showed no cross-resistance to hSGZ. Induced overexpression of Fn14 levels in MCF7 cells through HER2 (ERBB2) signaling translated to an improved therapeutic index of hSGZ treatment. In combination with trastuzumab, hSGZ showed an additive or synergistic cytotoxic effect on HER2(+)/Fn14(+) breast cancer cell lines. Also, hSGZ treatment inhibited Erb3/Akt signaling in HER2-overexpressing breast cancer cells. Pharmacokinetic studies in mice revealed that hSGZ exhibited a biexponential clearance from plasma with a rapid initial clearance (t1/2α = 1.26 hours) followed by a seven-fold longer plasma half-life (t1/2β = 7.29 hours). At 24, 48, and 72 hours after injection, uptake of the hSGZ into tumors was 5.1, 4.8, and 4.7%ID/g, with a tumor-to-muscle ratio of 5.6, 6.2, and 9.0, respectively. Therapeutic efficacy studies showed significant tumor inhibition effects using an MDA-MB-231/Luc breast cancer xenograft model. Our findings show that hSGZ is an effective anticancer agent and a potential candidate for clinical studies.
Modularized Field-Effect Transistor Biosensors (2019)

Field-effect transistors (FETs), when functionalized with proper biorecognition elements (such as antibodies or enzymes), represent a unique platform for real-time, specific, label-free transduction of biochemical signals. However, direct immobilization of biorecognition molecules on FETs imposes limitations on reprogrammability, sensor regeneration, and robust device handling. Here we demonstrate a modularized design of FET biosensors with separate biorecognition and transducer modules, which are capable of reversible assembly and disassembly. In particular, hydrogel "stamps" immobilizing bioreceptors have been chosen to build biorecognition modules to reliably interface with FET transducers structurally and functionally. Successful detection of penicillin down to 0.25 mM has been achieved with a penicillinase-encoded hydrogel module, demonstrating effective signal transduction across the hybrid interface. Moreover, sequential integration of urease- and penicillinase-encoded modules on the same FET device allows us to reprogram the sensing modality without cross-contamination. In addition to independent bioreceptor encoding, the modular design also fosters sophisticated control of sensing kinetics by modulating the physiochemical microenvironment in the biorecognition modules. Specifically, the distinction in hydrogel porosity between polyethylene glycol and gelatin enables controlled access and detection of larger molecules, such as poly-l-lysine (MW 150-300 kDa), only through the gelatin module. Biorecognition modules with standardized interface designs have also been exploited to comply with additive mass fabrication by 3D printing, demonstrating potential for low cost, ease of storage, multiplexing, and great customizability for personalized biosensor production. This generic concept presents a unique integration strategy for modularized bioelectronics and could broadly impact hybrid device development.
FGP: a virtual machine for acquiring knowledge from cases (1991)

Large case databases are numerous and packed with information. The largest of them are potentially rich sources of domain knowledge. The FGP machine is a software architecture that can make this knowledge explicit and bring it to bear on classification and prediction problems. The architecture provides much of the functionality of traditional expert systems without requiring the system builder to preprocess the database into rules, frames, or any other fixed abstraction. Implementations of the FGP machine use similarity-based reminding and the cases themselves to drive the inference engine. By having the system calculate and incorporate a measure of feature salience into its distance calculations, the FGP architecture smoothly copes with incomplete data and is particularly well-suited to weak-theory domains. We explain the model, describe a particular implementation of it, and present test-results for a classification task in three application areas.
Quadtree-structured linear prediction models for image sequence processing (1989)

A summary is presented of a study on two-dimensional linear prediction models for image sequence processing and its application to change detection and scene coding. The study focused on two-dimensional joint process modeling of interframe relationships, the derivation of computationally efficient matching algorithms, and the implementation of a block-adaptive interframe predictor for use in interframe predictive coding and change detection. In the approach presented, the spatial nonstationarity is handled by an underlying quadtree segmentation structure. A maximum-likelihood criterion and a simpler minimum-variance criterion are discussed as detection and segmentation rules. The results of this research indicate that a constrained joint process model involving only a single gain parameter and a shift parameter is the best tradeoff between performance and computational complexity.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Voronoi Diagrams in CGAL, the Computational Geometry Algorithms Library (2007)

CGAL, the computational geometry algorithms library, is a C++ library of geometric algorithms and data structures which is developed in the framework of the CGAL open source project. This talk gives an overview on the various types of Voronoi diagrams which are in the CGAL library or under development.
Selected Arylpiperazines Are Capable of Reversing Multidrug Resistance in <i>Escherichia coli</i> Overexpressing RND Efflux Pumps (2005)

Several arylpiperazines capable of reversing multidrug resistance (MDR) in Escherichia coli overexpressing acrAB and acrEF but not in pump-deficient mutant strains were identified. 1-(1-Naphthylmethyl)-piperazine, one of the more active compounds, enhanced susceptibility to fluoroquinolones and other agents and increased the intracellular concentration of levofloxacin and ethidium bromide, suggesting efflux pump inhibition as the mechanism of MDR reversal.
The starting process in long discharge tubes (1988)

The charge deposited on the wall of a long discharge tube is measured both as a function of the distance from the electrodes and of the time elapsed since the ignition voltage is applied. The charging of the wall is accompanied by emission of light, indicating ionisation and excitation processes in the gas. A model for the starting processes is presented which takes into account the spatio-temporal behaviour of the plasma resistance.
Oocyte normality after superovulation in immature rats (1983)

The developmental ability of oocytes recovered from superovulated immature rats (40 i.u. PMSG) was compared with that of oocytes from control rats (4 i.u. PMSG). Oocytes were collected from the oviducts immediately after ovulation or from large follicles, and were transferred to one ovarian bursa of normal adult recipients. Fertilization and subsequent fetal development occurred in the recipients which were killed on Day 20. The proportions of oocytes surviving after transfer from the oviducts of donors which received 4 or 40 i.u. PMSG or from the follicles of those which received 40 i.u. PMSG were not significantly different. However, the proportion of oocytes surviving after recovery from the follicles of donors receiving 4 i.u. PMSG was significantly higher (P less than 0.05). These studies suggest that oocytes recovered from superovulated or control rats are equally able to develop, and the failure to maintain pregnancy that has been reported for superovulated rats in previous studies is not attributable to defects in the oocytes.
Thrombogenicity Testing of Medical Devices in a Minimally Heparinized Ovine Blood Loop (2017)

ISO 10993-4 in vivo thrombogenicity testing is frequently performed for regulatory approval of many blood-contacting medical devices and is often a key part of submission packages. Given the current state of in vivo thrombogenicity assays, a more robust and reproducible assay design, including in vitro models, is needed. This study describes an in vitro assay that integrates freshly harvested ovine blood containing minimal heparin in a closed pumped loop. To confirm the reproducibility of this assay, control materials were identified that elicited either a positive or a negative thrombogenic response. These controls demonstrated reproducibility in the resulting thrombogenicity scores with median scores of 5 and 0 for the positive and negative controls, respectively, which also demonstrated a significant difference (p < 0.0001). For a direct comparison of the in vitro blood loop assay to the traditional in vivo nonanticoagulated venous implant (NAVI) assay, seven sheep were used as blood donors for the loop and then as subjects for an NAVI assay. In each assay—loop or NAVI—three study articles were used: the positive and negative controls and a marketed, approved catheter. The resulting thrombogenicity scores were similar when comparing the loop to the NAVI results. For each study article, the median thrombogenicity scores were the same in these two different assays, being 0, 1, and 5 for the negative control, the marketed catheter, and the positive control, respectively. These data suggest that the in vitro assay performs similarly to the in vivo NAVI assay. This in vitro blood loop method has the potential to predict a materials' in vivo thrombogenicity, can substantially de-risk the materials or coating selection process, and may eventually be able to replace the in vivo models currently in use.
Model-free control (2013)

"Model-free control" and the corresponding "intelligent" PID controllers (iPIDs), which already had many successful concrete applications, are presented here for the first time in an unified manner, where the new advances are taken into account. The basics of model-free control is now employing some old functional analysis and some elementary differential algebra. The estimation techniques become quite straightforward via a recent online parameter identification approach. The importance of iPIs and especially of iPs is deduced from the presence of friction. The strange industrial ubiquity of classic PID's and the great difficulty for tuning them in complex situations is deduced, via an elementary sampling, from their connections with iPIDs. Several numerical simulations are presented which include some infinite-dimensional systems. They demonstrate not only the power of our intelligent controllers but also the great simplicity for tuning them.
Production of natural folates by lactic acid bacteria starter cultures isolated from artisanal Argentinean yogurts (2012)

Folate is a B-group vitamin that cannot be synthesized by humans and must be obtained exogenously. Although some species of lactic acid bacteria (LAB) can produce folates, little is known about the production of this vitamin by yogurt starter cultures. Lactobacillus delbrueckii subsp. bulgaricus and Streptococcus thermophilus strains were isolated from artisanal Argentinean yogurts and were grown in folate-free culture medium (FACM) and nonfat milk after which intracellular and extracellular folate production were evaluated. From the initial 92 isolated LAB strains, 4 L. delbrueckii subsp. bulgaricus and 32 S. thermophilus were able to grow in the absence of folate. Lactobacillus delbrueckii subsp. bulgaricus CRL 863 and S. thermophilus CRL 415 and CRL 803 produced the highest extracellular folate levels (from 22.3 to 135 µg/L) in FACM. In nonfat milk, these strains were able to increase the initial folate concentrations by almost 190%. This is the first report where native strains of L. delbrueckii subsp. bulgaricus were shown to produce natural folate. The LAB strains identified in this study could be used in developing novel fermented products bio-enriched in natural folates that could in turn be used as an alternative to fortification with the controversial synthetic chemical folic acid.
Diastereoface-Selective Epoxidations: Dependency on the Reagent Electrophilicity (1998)

Substrate-imposed steric constraints can be overriden by the pronounced preference of strong peracids for epoxidation on the π face, which has the highest electron density. For example, the syn:anti ratio for reaction (1) with CF3CO3H in CH2Cl2 is 82:18, that with CH3CO3H in toluene is 3:97.
Neutrophil-to-Lymphocyte Ratio and Its Association with Critical Limb Ischemia in PAOD Patients (2013)

An increased NLR is significantly associated with patients at high risk for CLI and other vascular endpoints. The NLR is an easy to perform test, which could be used to highlight patients at high risk for vascular endpoints.
Sodium salicylate induces apoptosis via p38 mitogen-activated protein kinase but inhibits tumor necrosis factor-induced c-Jun N-terminal kinase/stress-activated protein kinase activation (1997)

In a previous study, we demonstrated that sodium salicylate (NaSal) selectively inhibits tumor necrosis factor (TNF)-induced activation of the p42 and p44 mitogen-activated protein kinases (MAPKs) (known as extracellular signal-regulated kinases). Here we show that in normal human FS-4 fibroblasts NaSal inhibits TNF-induced activation of another member of the MAPK family, the c-Jun N-terminal kinase/stress-activated protein kinase. c-Jun N-terminal kinase activation induced by interleukin 1 or epidermal growth factor was less strongly inhibited by NaSal. Unexpectedly, treatment of FS-4 cells with NaSal alone produced a strong activation of p38 MAPK and cell death by apoptosis. NaSal-induced apoptosis was blocked by the selective p38 MAPK inhibitor SB-203580, indicating that p38 MAPK serves as a mediator of NaSal-induced apoptosis in human fibroblasts. Activation of p38 MAPK and the resulting induction of apoptosis may be important in the demonstrated antineoplastic actions of nonsteroidal anti-inflammatory drugs.
Laser transfer of biomaterials: Matrix-assisted pulsed laser evaporation (MAPLE) and MAPLE Direct Write (2003)

Two techniques for transferring biomaterial using a pulsed laser beam were developed: matrix-assisted pulsed laser evaporation (MAPLE) and MAPLE direct write (MDW). MAPLE is a large-area vacuum based technique suitable for coatings, i.e., antibiofouling, and MDW is a localized deposition technique capable of fast prototyping of devices, i.e., protein or tissue arrays. Both techniques have demonstrated the capability of transferring large (mol wt&gt;100 kDa) molecules in different forms, e.g., liquid and gel, and preserving their functions. They can deposit patterned films with spatial accuracy and resolution of tens of μm and layering on a variety of substrate materials and geometries. MDW can dispense volumes less than 100 pl, transfer solid tissues, fabricate a complete device, and is computed aided design/computer aided manufacturing compatible. They are noncontact techniques and can be integrated with other sterile processes. These attributes are substantiated by films and arrays of biomaterials, e.g., polymers, enzymes, proteins, eucaryotic cells, and tissue, and a dopamine sensor. These examples, the instrumentation, basic mechanisms, a comparison with other techniques, and future developments are discussed.
A Maslov-propagator seismogram for weakly anisotropic media (2002)

We introduce a formalism to calculate shear-wave seismograms for weakly-anisotropic and inhomogeneous media. The method is based on the combination of the forward-propagator method, which accounts for shear-wave interaction along a single reference ray, and the Maslov ray-summation, which incorporates amplitude and phase information from neighbouring rays to account for waveform and diffraction effects at caustics and in shadow regions. The approach is based on the assumption that the multiply split shear waves, on the way to a given receiver, travel along a common ray path that can by obtained from ray tracing in an isotropic reference medium (i.e. the common-ray approximation). The forward propagator and the Maslov amplitude are expressed with respect to radial and transverse coordinates (perpendicular to the ray propagation direction) that are defined uniquely by the initial conditions. Local polarizations and slownesses of the fast and slow shear-waves in the direction of propagation are obtained from the eikonal equation. The Maslov-propagator phase is given by the average shear-wave traveltime along the reference ray. Phase advances and delays of individual shear wave components are accounted for by the propagator. The geometrical-spreading information required for the Maslov integration is supplied by dynamic ray tracing in the isotropic reference medium. In the high-frequency limit effective phase functions are defined to assess the validity of the Maslov propagator phase information. For a homogeneous isotropic reference medium, we find good agreement with exact Maslov phase functions for anisotropic perturbations of up to 20 per cent. As a numerical application we consider effects of inhomogeneous anisotropy in a shear-wave cross-hole survey. The variations of the transversely-isotropic medium require 2-D slowness integrals. The method can handle discontinuities of the fast polarization along the ray path and also for neighbouring rays which is important for the slowness integration. Smooth transitions between isotropic and anisotropic regions along the ray path can be accounted for without the need to switch between numerical formulations.
QSAR studies on drugs acting at the central nervous system (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTQSAR studies on drugs acting at the central nervous systemS. P. GuptaCite this: Chem. Rev. 1989, 89, 8, 1765–1800Publication Date (Print):December 1, 1989Publication History Published online1 May 2002Published inissue 1 December 1989https://pubs.acs.org/doi/10.1021/cr00098a007https://doi.org/10.1021/cr00098a007research-articleACS PublicationsRequest reuse permissionsArticle Views684Altmetric-Citations68LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Very Wide Register: An Asymmetric Register File Organization for Low Power Embedded Processors (2007)

In current embedded systems processors, multi-ported register files are one of the most power hungry parts of the processor, even when they are clustered. This paper presents a novel register file architecture, which has single ported cells and asymmetric interfaces to the memory and to the datapath. Several realistic kernels from the TI DSP benchmark and from software defined radio (SDR) are mapped on the architecture. A complete physical design of the architecture is done in TSMC 90nm technology. The novel architecture presented is shown to obtain energy gains of up to 10times with respect to conventional multi-ported register file over the different benchmarks