gebhart/patrepeval huggingface dataset:
The transgenic window on lymphoid malignancy. (1989)

Transgenic mice bearing an oncogene targetted for expression in a specific tissue can reveal how that oncogene influences differentiation and help to delineate the pathways to malignancy. To explore lymphoid neoplasia, we have made strains of transgenic mice bearing different oncogenes driven by the immunoglobulin heavy chain enhancer (E mu), which promotes expression within lymphocytes and certain myeloid cells. The prototype E mu-myc mice succumb to pre-B and B cell lymphomas, following a preneoplastic phase in which cycling pre-B cells are overproduced. The similar fate of E mu-N-myc mice suggests that N-myc and myc have overlapping functions. Surprisingly, E mu-N-ras mice develop T lymphomas and macrophage tumours but no B lineage tumours; thus the ability of ras to initiate tumorigenesis may be lineage specific. Similarly, the high predisposition of E mu-v-abl mice to develop plasmacytomas may indicate that v-abl is oncogenic only at certain stages of B cell maturation. The bcl-2 gene promotes cell survival rather than proliferation, and E mu-bcl-2 mice produce copious resting B lymphocytes. The random onset and monoclonality of tumours in the transgenic strains argues for spontaneous genetic alterations that cooperate with the trans-oncogene. Indeed, most plasmacytomas of E mu-v-abl mice bear spontaneous myc rearrangements. Moreover, a minority of E mu-myc B lymphomas exhibit ras mutation, and the tumorigenesis can be reconstructed by crossing E mu-myc and E mu-ras mice, or by retroviral delivery of v-ras or v-raf, either in vitro or in vivo. To access novel cooperating oncogenes, we are using a retrovirus lacking an oncogene as an insertional mutagen. This approach should be applicable to any trans-oncogenic strain and help to delineate the genetic events that trigger malignant clones.
Functional Protection of Human Haemoglobin Against Protein Dissociation (2000)

The spectroscopic and functional properties of human adult haemoglobin are clearly disrupted by concentrations of urea > 0.4 M. This disruption of structure and function is completely obviated by the presence of 0.2 M trimethylamine N-oxide (TMAO). Spectroscopic data suggest that TMAO prevents urea-induced production of high-spin haem. Functional analysis shows that TMAO exerts its influence by counteracting urea-induced destabilisation of the T state of the haemoglobin protein. Further studies show, however, that TMAO is not able to exert any such stabilising influences in the presence of high concentrations of typical organic solvent denaturants.
Substrate Bias Effect on Diamond Deposition by DC Plasma Jet (1990)

By applying positive bias voltage to a substrate in diamond CVD by a dc plasma jet of the Ar–H 2 –CH 4 system, the deposition rate increased more than twofold, and the maximum rate of 15 µm/min was obtained. The deposition area also increased but the uniformity of film thickness did not improve. Applying the bias voltage to a ring electrode around the substate increased the deposition rate by nearly the same amount without increasing the substrate temperature.
Review: <i>Anatomy and Physiology: The Basic Principles</i>, by William F. Evans (1971)

Book Review| December 01 1971 Review Anatomy and Physiology: The Basic PrinciplesWilliam F. Evans Margaret L. Watson Margaret L. Watson Search for other works by this author on: This Site PubMed Google Scholar The American Biology Teacher (1971) 33 (9): 564. https://doi.org/10.2307/4443734 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Margaret L. Watson; Review. The American Biology Teacher 1 December 1971; 33 (9): 564. doi: https://doi.org/10.2307/4443734 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu nav search search input Search input auto suggest search filter All ContentThe American Biology Teacher Search This content is only available via PDF. Copyright 1971 National Association of Biology Teachers Article PDF first page preview Close Modal You do not currently have access to this content.
Number representations for reducing data bus power dissipation (2002)

In the usual two's complement representation of data, sign extensions in the higher-order bit positions can lead to a great deal of data bus switching activity. It is shown that the use of signed-digit representations can mitigate this effect. A negabinary representation (equivalent to a nonredundant sign-digit formulation) reduced data bus switching activity to a degree comparable to that provided by the better-known sign-magnitude notation.
Multi-Modal Data Augmentation for End-to-End ASR (2018)

We present a new end-to-end architecture for automatic speech recognition (ASR) that can be trained using \emph{symbolic} input in addition to the traditional acoustic input. This architecture utilizes two separate encoders: one for acoustic input and another for symbolic input, both sharing the attention and decoder parameters. We call this architecture a multi-modal data augmentation network (MMDA), as it can support multi-modal (acoustic and symbolic) input and enables seamless mixing of large text datasets with significantly smaller transcribed speech corpora during training. We study different ways of transforming large text corpora into a symbolic form suitable for training our MMDA network. Our best MMDA setup obtains small improvements on character error rate (CER), and as much as 7-10\% relative word error rate (WER) improvement over a baseline both with and without an external language model.
Theory and Applications of Robust Optimization (2010)

In this paper we survey the primary research, both theoretical and applied, in the area of robust optimization (RO). Our focus is on the computational attractiveness of RO approaches, as well as the modeling power and broad applicability of the methodology. In addition to surveying prominent theoretical results of RO, we also present some recent results linking RO to adaptable models for multistage decision-making problems. Finally, we highlight applications of RO across a wide spectrum of domains, including finance, statistics, learning, and various areas of engineering.
Thermoluminescence in Single Crystal Alpha-Al2O3 (1984)

Revue des proprietes de thermoluminescence entre 10 et 700 K du fait de l'irradiation aux rayons UV, X ou γ. Identification des pieges concernes et determination du signe des porteurs de charge d'apres d'autres mesures telles que la conduction thermostimulee, la RPE et l'absorption optique
The Acid-Inducible <i>asr</i> Gene in <i>Escherichia coli</i> : Transcriptional Control by the <i>phoBR</i> Operon (1999)

Escherichia coli responds to external acidification (pH 4.0 to 5.0) by synthesizing a newly identified, approximately 450-nucleotide RNA component. At maximal levels of induction it is one of the most abundant small RNAs in the cell and is relatively stable bacterial RNA. The acid-inducible RNA was purified, and the gene encoding it, designated asr (for acid shock RNA), mapped at 35.98 min on the E. coli chromosome. Analysis of the asr DNA sequence revealed an open reading frame coding for a 111-amino-acid polypeptide with a deduced molecular mass of approximately 11.6 kDa. According to computer-assisted analysis, the predicted polypeptide contains a typical signal sequence of 30 amino acids and might represent either a periplasmic or an outer membrane protein. The asr gene cloned downstream from a T7 promoter was translated in vivo after transcription using a T7 RNA polymerase transcription system. Expression of a plasmid-encoded asr::lacZ fusion under a native asr promoter was reduced approximately 15-fold in a complex medium, such as Luria-Bertani medium, versus the minimal medium. Transcription of the chromosomal asr was abolished in the presence of a phoB-phoR (a two-component regulatory system, controlling the pho regulon inducible by phosphate starvation) deletion mutant. Acid-mediated induction of the asr gene in the Delta(phoB-phoR) mutant strain was restored by introduction of the plasmid with cloned phoB-phoR genes. Primer extension analysis of the asr transcript revealed a region similar to the Pho box (the consensus sequence found in promoters transcriptionally activated by the PhoB protein) upstream from the determined transcription start. The asr promoter DNA region was demonstrated to bind PhoB protein in vitro. We discuss our results in terms of how bacteria might employ the phoB-phoR regulatory system to sense an external acidity and regulate transcription of the asr gene.
Mechanical Properties of Silicon Carbonitride Thin Films (2003)

Silicon carbonitride thin films were synthesized by reactive rf sputtering a silicon carbide target in nitrogen and argon atmosphere, or sputtering a silicon nitride target in methane and argon atmosphere, respectively. The Nanoindentation technique (Nanoindenter XP system with a continuous stiffness measurement technique) was employed to measure the hardness and elastic modulus of thin films. The effects of sputtering power on the mechanical properties are different for the two SiCN thin films. With increasing sputtering power, the hardness and the elastic modulus decrease for the former but increase for the latter. The tendency is similar to the evolution trend of Si–C bonds in SiCN materials. This reflects that Si–C bonds provide greater hardness for SiCN thin films than Si–N and C–N bonds.
pH-Sensitive Cationic Polymer Gene Delivery Vehicle:  <i>N</i>-Ac-poly(<scp>l</scp>-histidine)-graft-poly(<scp>l</scp>-lysine) Comb Shaped Polymer (2000)

Advancing biotechnology spurs the development of new pharmaceutically engineered gene delivery vehicles. Poly(L-histidine) ¿PLH¿ has been shown to induce membrane fusion at endosomal pH values, whereas PLL has a well documented efficacy in polyplex formation. Therefore, N-Ac-poly(L-histidine)-graft-poly(L-lysine) ¿PLH-g-PLL¿ was synthesized by grafting poly(L-histidine) to poly(L-lysine) ¿PLL¿. PLH-g-PLL formed polyplex particles by electrostatic interactions with plasmid DNA ¿pDNA¿. The mean particle size of the polyplexes was in the range of 117 +/- 6 nm to 306 +/- 77 nm. PLH-g-PLL gene carrier demonstrated higher transfection efficacy in 293T cells than PLL at all equivalent weight ratios with pDNA. The inclusion of chloroquine as an endosomolytic agent enhanced transfection for both PLL and PLH-g-PLL gene carriers. PLH-g-PLL enhanced beta-galactosidase expression compared to PLL, but still increased in efficacy when chloroquine was included.
Cytosine Methylation: Quantitation by Automated Genomic Sequencing and GENESCAN <sup>TM</sup> Analysis (1996)

Bisulfite treatment and PCR amplification of genomic DNA permits the methylation analysis of any cytosine residue in a target sequence. By cloning and sequencing the PCR product, the methylation of individual molecules can be determined, whereas direct sequencing of the PCR product can provide an average of the methylation status in the population of molecules. Reliable quantitation of cytosine methylation by direct sequencing, however, has not been possible with current methods. In this paper we describe an accurate and innovative protocol to directly quantitate the methylation of any cytosine residue in the target sequence by fluorescence-based automated genomic sequencing. Only the cytosine and thymine residues of bisulfite-treated and amplified genomic DNA are sequenced. The degree of methylation is obtained by direct comparison of the cytosine and thymine signals, which have been labeled with the same fluorescent dyes. GENESCAN analysis is employed to achieve a fast and accurate estimate of methylation at every cytosine in the target sequence. Combining direct bisulfite genomic sequencing and GENESCAN analysis permits the rapid survey of detailed DNA methylation profiles. Using this approach we have found the unexpected result that multicopy plasmid DNA grown in a Dcm host is not always fully methylated as suggested by restriction enzyme data.
Sodium ascorbyl phosphate shows <i>in vitro</i> and <i>in vivo</i> efficacy in the prevention and treatment of acne vulgaris (2005)

Acne vulgaris is the most common inflammatory skin disorder and jeopardizes seriously the facial impression of a person. Development of acne involves a complex relation among several causes. Treatment and prevention success can be archived by affecting the main contributors positively like Proprionibacterium acnes or lipid oxidation leading to inflammatory reactions and follicular keratinization. Vitamin C tends to break down in cosmetic formulations resulting in a brownish discoloration. Sodium ascorbyl phosphate (SAP) represents a stable precursor of vitamin C that ensures a constant delivery of vitamin C into the skin. We were able to show that 1% SAP has a strong antimicrobial effect with a log reduction of 5 after 8 h on P. acnes in a time-kill study. Further on in a human in vivo study with 20 subjects an SAP O/W formulation significantly prevents the UVA-induced sebum oxidation up to 40%. Finally, we performed an open in vivo study with 60 subjects with a 5% SAP lotion over 12 weeks. The efficacy ranked as excellent and good of SAP was 76.9%, which was superior compared with a widely prescribed acne treatment. In conclusion, these data show that SAP is efficient in the prevention and treatment of acne vulgaris. SAP can be used in a non-antibiotic and effective treatment or co-treatment of acne with no side effects, which makes it particularly attractive for cosmetic purposes.
REMOTE SENSING OF THERMAL WATER STRESS INDICATORS IN PEACH (2012)

Canopy temperature is a well known indicator of water stress, as any reduction in canopy conductance due to stomatal closure results in a further increase of canopy temperature. However, canopy temperature is affected by different ambient factors, such as air temperature, vapor pressure deficit, and net radiation, among others. Standardization is required in order to obtain reliable indicators of plant water status from canopy temperature. Different approaches have been developed during the past decades, such as the Crop Water Stress Index (CWSI) developed in the 80s by Idso and Jackson's group (Idso et al., 1981), providing a normalized 0-1 index to quantify water stress independently of air temperature and humidity. Nevertheless, extensive use of thermal based indicators to map water stress has been limited by the lack of spatial and temporal resolution of satellite sensors. Airborne thermal scanners could provide an alternative, but the high operational costs and complexity have limited their use to real applications. Nowadays the use of commercial off-the-shelf thermal sensors onboard of Unmanned Aerial Vehicles (UAVs) offers a new important monitoring option for water management of high value crops such as fruit trees. © ISHS 2012.
Syntheses of Shell Cross-Linked Micelles Using Acidic ABC Triblock Copolymers and Their Application as pH-Responsive Particulate Emulsifiers (2005)

The use of new shell cross-linked micelles as pH-responsive particulate emulsifiers is described for the first time. 1-Undecanol-in-water emulsions of 18 mum diameter are formed at pH 8, whereas complete demulsification occurs at pH 2.
Internet of Mobile Things: Overview of LoRaWAN, DASH7, and NB-IoT in LPWANs Standards and Supported Mobility (2018)

Low-power wide area networks (LPWANs) constitute a type of networks which is used to connect things to the Internet from a wide variety of sectors. These types of technologies provide the Internet of Things (IoT) devices with the ability to transmit few bytes of data for long ranges, taking into consideration minimum power consumption. In parallel, IoT applications will cover a wide range of human and life needs from smart environments (cities, home, transportation, etc.) to health and quality of life. Among these popular LPWANs technologies, we have identified the unlicensed frequency band (LoRa, DASH7, SigFox, Wi-SUN, etc.), and the licensed frequency band standards (NB-IoT, LTE Cat-M, EC-GSM-IoT, etc.). In general, both types of standards only consider fixed interconnected things, and less attention has been provided to the mobility of the things or devices. In this paper, we address the mobility of the things and the connectivity in each of the three LPWAN standards: LoRaWAN, DASH7, and NB-IoT. In particular, we show how the mobility of things can be achieved when transmitting and receiving data. Then, we provide a general and technical comparison for the three standards. Finally, we illustrate several application scenarios where the mobility is required, and we show how to select the most suited standard. We also discuss the research challenges and perspectives.
Ensemble non-negative matrix factorization methods for clustering protein–protein interactions (2008)

We apply the proposed Ensemble non-negative matrix factorization (NMF) algorithm to a high-quality assembly of binary protein interactions derived from two proteome-wide studies in yeast. Our experimental evaluation demonstrates that the algorithm lends itself to discovering small localized structures in this data, which correspond to known functional groupings of complexes. In addition, we show that the algorithm also supports the assignment of putative functions for previously uncharacterized proteins, for instance the protein YNR024W, which may be an uncharacterized component of the exosome.
Construction of Ureteral Grafts by Seeding Urothelial Cells and Bone Marrow Mesenchymal Stem Cells into Polycaprolactone-Lecithin Electrospun Fibers (2010)

The aim of the present study was to investigated the construction of polycaprolactone-lecithin (PCL-L) electrospun fibers as a novel scaffold material for a tissue-engineered ureter. The effect of bone marrow mesenchymal stem cells (BM-MSCs) on the neovascularization of the scaffolds and the viability of planted urothelial cells (UCs) on PCL-L were also studied. UCs were obtained from New Zealand rabbit bladders, cultured and then seeded onto the lumen of the tubular scaffolds before being subcutaneously transplanted into the space of nude mice. The cultured UCs showed vacuolar degeneration after 7 days of transplantation and they gradually degraded thereafter. To facilitate the regeneration of the tissue-engineered ureter and the survival of UCs in the implant, MSCs were seeded into the tubular grafts by rolling up the nanofibrous membrane, followed by the seeding of UCs. This facilitated the survival of the UCs, which formed several cellular layers after 30 days. The mean microvessel density was significantly increased in tissues seeded with MSCs. Cell-tracking experiments revealed that the transplanted MSCs did not integrate directly into capillaries for angiogenesis. Our results demonstrated that the PCL-L electrospun fibrous scaffold has a high potential for a tissue-engineered ureter especially when seeded with BM-MSCs, which enhanced angiogenesis.
Top Executive Locus of Control and Its Relationship to Strategy-Making, Structure, and Environment. (1982)

In a Canadian study the locus of control of top executives was found to bear a direct and significant relationship to the nature of corporate strategy but an indirect relationship to environment an...
On pseudo-bci ideals of pseudo-bci algebras (2006)

Abstract. The notions of pseudo-atoms, pseudo-BCI ideals and pseudo-BCI homomor-phisms in pseudo-BCI algebras are introduced. Characterizations of a pseudo-BCI ideal are displayed, and conditions for a subset to be a pseudo-BCI ideal are given. The concept of a -medial pseudo-BCI algebra is also introduced, and its characterization is provided. We show that every pseudo-BCI homomorphic image and preimage of a pseudo-BCI ideal is also a pseudo-BCI ideal. 1.
Whistler-wave electron cyclotron heating in uniform and nonuniform magnetic fields (1990)

Recent laboratory experiments on single-pass electron cyclotron heating employing whistler waves [Phys. Fluids B 1, 2010 (1989)] have shown direct evidence of nonlinear collective processes that can have a major effect on the properties of the resulting plasma. A theoretical interpretation of these experimental results is proposed herein, based on linear and nonlinear aspects of electron cyclotron heating. The observed increments in electron kinetic energy are shown to be consistent with a conventional linearized analysis of the gyroresonant interaction. The observed bursts of radiation in sidebands near the heating frequency are consistent with the nonlinear gyrophase bunching of resonant electrons in the whistler wave resulting in coherent excitation of unstable sidebands.
Role of Gardnerella vaginalis in the Pathogenesis of Bacterial Vaginosis: A Conceptual Model (2014)

G. vaginalis is the pathogen responsible for the initiation of BV. Future research should focus on preventing its transmission and improved therapeutics for the biofilm infection that is caused by this pathogen and host anaerobes.
Central Nervous System Metastases in Patients with HER2-Positive Metastatic Breast Cancer: Incidence, Treatment, and Survival in Patients from registHER (2011)

For patients with HER2-positive MBC evaluated in registHER, the use of trastuzumab, chemotherapy, and surgery following CNS metastases were each associated with longer survival.
Synthesis, Crystal Structure Determination and Antiproliferative Evaluation of Novel Benzazoyl Benzamides. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Regulation of Inflammatory Chemokine Receptors on Blood T Cells Associated to the Circulating Versus Liver Chemokines in Dengue Fever (2012)

Little is known about the role of chemokines/chemokines receptors on T cells in natural DENV infection. Patients from DENV-2 and -3- outbreaks were studied prospectively during the acute or convalescent phases. Expression of chemokine receptor and activation markers on lymphocyte subpopulations were determined by flow cytometry analysis, plasma chemokine ligands concentrations were measured by ELISA and quantification of CCL5/RANTES(+) cells in liver tissues from fatal dengue cases was performed by immunochemistry. In the acute DENV-infection, T-helper/T-cytotoxic type-1 cell (Th1/Tc1)-related CCR5 is significantly higher expressed on both CD4 and CD8 T cells. The Th1-related CXCR3 is up-regulated among CD4 T cells and Tc2-related CCR4 is up-regulated among CD8 T cells. In the convalescent phase, all chemokine receptor or chemokine ligand expression tends to reestablish control healthy levels. Increased CCL2/MCP-1 and CCL4/MIP-1β but decreased CCL5/RANTES levels were observed in DENV-patients during acute infection. Moreover, we showed an increased CD107a expression on CCR5 or CXCR3-expressing T cells and higher expression of CD29, CD44(HIGH) and CD127(LOW) markers on CCR4-expressing CD8 T cells in DENV-patients when compared to controls. Finally, liver from dengue fatal patients showed increased number of cells expressing CCL5/RANTES in three out of four cases compared to three death from a non-dengue patient. In conclusion, both Th1-related CCR5 and CXCR3 among CD4 T cells have a potential ability to exert cytotoxicity function. Moreover, Tc1-related CCR5 and Tc2-related CCR4 among CD8 T cells have a potential ability to exert effector function and migration based on cell markers evaluated. The CCR5 expression would be promoting an enhanced T cell recruitment into liver, a hypothesis that is corroborated by the CCL5/RANTES increase detected in hepatic tissue from dengue fatal cases. The balance between protective and pathogenic immune response mediated by chemokines during dengue fever will be discussed.