gebhart/patrepeval huggingface dataset:
Productivity and quality improvements in health care through airboss mobile messaging services. (1997)

The US health care industry is in the midst of revolutionary changes. Under tremendous pressures from third-party payers and managed care programs to control costs while providing high quality medical services, health care entities are now looking at information technologies to help them achieve their goals. These goals typically include improved productivity, efficiency and decision-making capabilities among staff members. Moreover, hospitals and other health care facilities that provide a broad and integrated range of inpatient and outpatient care, wellness and home care services are in the best position to offer comprehensive packages to managed care and private insurers. Many health care providers and administrators are considered mobile employees. This mobility can range from intra-building and intra-campus to multi-site and metropolitan areas. This group often relies on a variety of information technologies such as personal computers, communicating laptops, pagers, cellular phones, wireline phones, cordless phones and fax machines to stay in touch and handle information needs. These health care professionals require mobile information access and messaging tools to improve communications, control accessibility and enhance decision-making capabilities. AirBoss mobile messaging services could address the health care industry's need for improved messaging capabilities for its mobile employees. The AirBoss family of services supports integrated voice services, data messaging, mobile facsimile and customized information delivery. This paper describes overview of the current mobile data networking capability, the AirBoss architecture, the health care-related applications it addresses and long-term benefits. In addition, a prototype application for mobile home health care workers is illustrated. This prototype application provides integrated e-mail, information services, web access, real-time access and update of patient records from wireline or wireless networks, and cross media delivery and notification. It provides seamless wide area access to patient data in a secure environment, thus providing a continuity of care from the hospital to home.
Identification of PLOD2 as Telopeptide Lysyl Hydroxylase, an Important Enzyme in Fibrosis (2003)

The hallmark of fibrotic processes is an excessive accumulation of collagen. The deposited collagen shows an increase in pyridinoline cross-links, which are derived from hydroxylated lysine residues within the telopeptides. This change in cross-linking is related to irreversible accumulation of collagen in fibrotic tissues. The increase in pyridinoline cross-links is likely to be the result of increased activity of the enzyme responsible for the hydroxylation of the telopeptides (telopeptide lysyl hydroxylase, or TLH). Although the existence of TLH has been postulated, the gene encoding TLH has not been identified. By analyzing the genetic defect of Bruck syndrome, which is characterized by a pyridinoline deficiency in bone collagen, we found two missense mutations in exon 17 of PLOD2, thereby identifying PLOD2 as a putative TLH gene. Subsequently, we investigated fibroblasts derived from fibrotic skin of systemic sclerosis (SSc) patients and found that PLOD2 mRNA is highly increased indeed. Furthermore, increased pyridinoline cross-link levels were found in the matrix deposited by SSc fibroblasts, demonstrating a clear link between mRNA levels of the putative TLH gene (PLOD2) and the hydroxylation of lysine residues within the telopeptides. These data underscore the significance of PLOD2 in fibrotic processes.
Fast motion compensated temporal interpolation for video (1995)

Recently, MPEG-4 is being formed to study very-low-bit-rate (VLBR) video coding for applications in videotelephony. In this paper, we propose a possible postprocessing technique for VLBR coding. In videophone applications, temporal subsampling is a simple technique which can be combined with other compression schemes to achieve very large compression ratio, so as to satisfy the VLBR requirement. As a result, object motions tend to be jerky and disturbing to the human eyes. To smooth out object motions, we propose a postprocessing technique, motion compensated temporal interpolation (MCTI), to increase the instantaneous decoder frame rate. In MCTI, block-based exhaustive motion search is used to establish temporal association between two reconstructed frames. Both forward and backward searches are used to account for uncovered and newly covered areas properly. With MCTI, we show that one or more frames can be interpolated with acceptable visual quality. After showing the feasibility of MCTI, we propose a fast algorithm FMCTI with reduced computation requirement and negligible performance degradation.© (1995) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
A new cell proliferating marker: cytosolic thymidine kinase as compared to proliferating cell nuclear antigen in patients with colorectal carcinoma. (2001)

TK1-LI showed more potential as a proliferating marker in colorectal carcinoma than PCNA-LI, especially for evaluating high-risk tumor grade and advanced stage in colorectal carcinoma.
Thermal Cyclization of Nonconjugated Aryl-Yne-Carbodiimide Furnishing a Dibenzonaphthyridine Derivative (2009)

The reagent-free C(2)-C(7) thermal cyclization of a nonconjugated aryl-yne-carbodiimide yielded a dibenzo[b,g][1,8]naphthyridine derivative, whose congeners are known to possess fascinating pharmacological properties. This is the first heteroaromatic compound prepared by the thermal cycloaromatization of "nonconjugated" aryl-ynes.
Fourier Transform Infrared Spectroscopy Study of CO Electro-oxidation on Pt(111) in Alkaline Media (2009)

In this work we investigate the electro-oxidation of CO on Pt(111) in alkaline solution by using Fourier transform infrared spectroscopy (FTIRS), to determine the adsorption sites of the CO, the intermediate species and the final oxidation product as a function of the applied potential. Multiple CO vibration bands (on-top, bridge and 3-fold hollow site) are observed on the Pt(111) electrode, their distribution and potential dependence being strongly dependent on the surface treatment. Spectroscopic results show that the final reaction product is carbonate and suggest that adsorbed carbonate blocks the access of CO from the (111) terrace to the active sites (i.e., step and kink sites).
Am80, a retinoic acid receptor agonist, ameliorates murine vasculitis through the suppression of neutrophil migration and activation (2012)

Am80 significantly suppressed CAWS-induced vasculitis. This effect was presumably exerted via inhibition of neutrophil migration and activation.
Aib Residues in Peptaibiotics and Synthetic Sequences: Analysis of Nonhelical Conformations (2008)

The alpha-aminoisobutyric (Aib) residue has generally been considered to be a strongly helicogenic residue as evidenced by its ability to promote helical folding in synthetic and natural sequences. Crystal structures of several peptide natural products, peptaibols, have revealed predominantly helical conformations, despite the presence of multiple helix-breaking Pro or Hyp residues. Survey of synthetic Aib-containing peptides shows a preponderance of 3(10)-, alpha-, and mixed 3(10)/alpha-helical structures. This review highlights the examples of Aib residues observed in nonhelical conformations, which fall 'primarily' into the polyproline II (P(II)) and fully extended regions of conformational space. The achiral Aib residue can adopt both left (alpha(L))- and right (alpha(R))-handed helical conformations. In sequences containing chiral amino acids, helix termination can occur by means of chiral reversal at an Aib residue, resulting in formation of a Schellman motif. Examples of Aib residues in unusual conformations are illustrated by surveying a database of Aib-containing crystal structures.
THE EVOLUTION OF MALE TRAITS IN SOCIAL INSECTS (2004)

Pair formation in social insects mostly happens early in adult life and away from the social colony context, which precludes promiscuity in the usual sense. Termite males have continuous sperm production, but males of social Hymenoptera have fixed complements of sperm, except for a few species that mate before female dispersal and show male-fighting and lifelong sperm production. We develop an evolutionary framework for testing sexual selection and sperm competition theory across the advanced eusocial insects (ants, wasps, bees, termites) and highlight two areas related to premating sexual selection (sexual dimorphism and male mate number) that have remained understudied and in which considerable progress can be achieved with relatively simple approaches. We also infer that mating plugs may be relatively common, and we review further possibilities for postmating sexual selection, which gradually become less likely in termite evolution, but for which eusocial Hymenoptera provide unusual opportunities because they have clonal ejaculates and store viable sperm for up to several decades.
Single-axial mode, intracavity doubled Nd:YAG laser (1991)

A diode-pumped, single-axial mode, intracavity doubled laser has been demonstrated using a cavity consisting of only two intracavity components, a Brewster angle cut piece of Nd:YAG and a KTP doubling crystal. Up to 4 mW single-ended output power has been obtained for 260 mW incident power on the Nd:YAG. Threshold power was 31 mW of diode power incident on the YAG; thus, single-mode operation was attained at up to approximately 8.5 times threshold. At the highest power the laser was susceptible to multimode operation due to spatial hole burning effects but below approximately 5 times threshold reliable single mode operation was achievable.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Studies on the nutrition of the large yellow croaker, <i>Pseudosciaena crocea</i> R. I: growth response to graded levels of dietary protein and lipid (2001)

The suitable protein-to-lipid ratio for juvenile large yellow croaker, Pseudosciaena crocea Richardson (initial body weight, 0.57 ± 0.11 g) was determined using practical diets in a 4 × 3 factorial experiment. Four dietary protein levels (34%, 37%, 42% and 47%) and three dietary lipid levels (7.5%, 10.5% and 14.0%) were tested. Each of the 12 diets was fed to triplicate groups of croaker juveniles for 60 days in floating netcages (1.0 × 1.0 × 2.0 m3) in the sea. The effects of dietary treatments on survival, weight gain, feed conversion ratio, protein efficiency ratio, hepatosomatic index and carcass composition of the fish were evaluated. At all three lipid levels, the best growth was always obtained in the fish fed diets of 47% protein. At 34% protein, better growth was observed for the fish fed the diet with 10.5% lipid, whereas at the protein levels above 37% the diets containing 10.5% and/or 14.0% lipid proved better. Based on the results of current experiment, the dietary protein:lipid ratio of 47:10.5 appeared to be suitable for this fish. Feed conversion ratio ranged from 1.40 to 1.98, declining with the increases of both dietary protein and lipid. The carcass lipid was correlated positively to dietary lipid, unlike the carcass protein that was independent of dietary protein. There was no interaction between dietary protein and lipid except for carcass lipid. Further investigations should be conducted to determine the optimal protein-to-lipid ratio for large yellow croaker juveniles using diets containing higher levels of protein and lipid than 47% and 14%, respectively.
Diagnostics of a Chemically Active, Pulsed Microwave Plasma for Deposition of Quartz‐like Films (1999)

Abstract A remote microwave plasma has been used for the deposition of scratch‐resistant quartz‐like films. Process gases are argon, oxygen, and hexamethyl‐disiloxane. Input power is modulated and the effects on the plasma as well as on the deposition process are studied by means of various diagnostic methods. The film deposition rate is slightly reduced under most conditions but film quality (i.e., cluster size, roughness, scratch resistance) may be improved. A precursor has been identified by mass spectrometric measurements. Its relation to volatile oxides is discussed. The atomic oxygen density and the electron density are determined temporally‐resolved. By a suitable choice of the pulse frequency the time‐averaged densities of both species can be significantly enhanced as compared to the continuous case. Consideration of the plasma power balance explains how electron density and temperature are influenced by pulsing. It is concluded that the optimum pulse frequency has to be matched to the electron loss rate which mainly depends on the geometrical dimensions of the process chamber.
A Comparative Study of Flavonoid Compounds, Vitamin C, and Antioxidant Properties of Baby Leaf <i>Brassicaceae</i> Species (2008)

A comparative study of antioxidant compounds, flavonoids and vitamin C, and also antioxidant activity was carried out in four species of Brassicaceae vegetables used for salads: watercress ( Nasturtium officinale R. Br.), mizuna [ Brassica rapa L. subsp. nipposinica (L.H. Bailey) Haneltand], wild rocket [ Diplotaxis tenuifolia (L.) DC.], and salad rocket [ Eruca vesicaria (L.) Cav.]. The characterization of individual phenolic compounds by HPLC-DAD-MS/MS-ESI in watercress and mizuna completes the polyphenol study previously reported for wild rocket and salad rocket. The qualitative study of flavonoids in watercress leaves showed a characteristic glycosylation pattern with rhamnose at the 7 position. Isorhamnetin 3,7-di- O-glucoside was identified in mizuna leaves and may be considered a chemotaxonomical marker in some B. rapa subspecies. Brassicaceae species showed differences in the quantitative study of flavonoids, and the highest content was detected in watercress leaves. Watercress and wild rocket leaves had the highest content of vitamin C. The antioxidant activity evaluated by different methods (ABTS, DPPH, and FRAP assays) showed a high correlation level with the content of polyphenols and vitamin C. In conclusion, the Brassicaceae leaves studied, watercress, mizuna, wild rocket, and salad rocket, presented a large variability in the composition and content of antioxidant compounds. These baby leaf species are good dietary sources of antioxidants with an important variability of bioactive compounds.
Icatibant, a New Bradykinin-Receptor Antagonist, in Hereditary Angioedema (2010)

In patients with hereditary angioedema having acute attacks, we found a significant benefit of icatibant as compared with tranexamic acid in one trial and a nonsignificant benefit of icatibant as compared with placebo in the other trial with regard to the primary end point. The early use of rescue medication may have obscured the benefit of icatibant in the placebo trial. (Funded by Jerini; ClinicalTrials.gov numbers, NCT00097695 and NCT00500656.)
Is triclosan harming your microbiome? (2016)

Studies on the effects of a widely used antimicrobial reach conflicting results
Repeated <scp><scp>H<sub>2</sub>O<sub>2</sub></scp></scp> exposure drives cell cycle progression in an <i>in vitro</i> model of ulcerative colitis (2013)

The production of hydrogen peroxide (H2 O2 ) drives tumourigenesis in ulcerative colitis (UC). Recently, we showed that H2 O2 activates DNA damage checkpoints in human colonic epithelial cells (HCEC) through c-Jun N-terminal Kinases (JNK) that induces p21(WAF1) . Moreover, caspases circumvented the G1/S and intra-S checkpoints, and cells accumulated in G2/M. The latter observation raised the question of whether repeated H2 O2 exposures alter JNK activation, thereby promoting a direct passage of cells from G2/M arrest to driven cell cycle progression. Here, we report that increased proliferation of repeatedly H2 O2 -exposed HCEC cells (C-cell cultures) was associated with (i) increased phospho-p46 JNK, (ii) decreased total JNK and phospho-p54 JNK and (iii) p21(WAF1) down-regulation. Altered JNK activation and p21(WAF1) down-regulation were accompanied by defects in maintaining G2/M and mitotic spindle checkpoints through adaptation, as well as by apoptosis resistance following H2 O2 exposure. This may cause increased proliferation of C-cell cultures, a defining initiating feature in the inflammation-carcinoma pathway in UC. We further suggest that dysregulated JNK activation is attributed to a non-apoptotic function of caspases, causing checkpoint adaptation in C-cell cultures. Additionally, loss of cell-contact inhibition and the overcoming of senescence, hallmarks of cancer, contributed to increased proliferation. Furthermore, there was evidence that p54 JNK inactivation is responsible for loss of cell-contact inhibition. We present a cellular model of UC and suggest a sinusoidal pattern of proliferation, which is triggered by H2 O2 -induced reactive oxygen species generation, involving an interplay between JNK activation/inactivation, p21(WAF1) , c-Fos, c-Jun/phospho-c-Jun, ATF2/phospho-ATF2, β-catenin/TCF4-signalling, c-Myc, CDK6 and Cyclin D2, leading to driven cell cycle progression.
Determination of 50% endpoint titer using a simple formula (2016)

Two commonly used methods for calculating 50% endpoint using serial dilutions are Spearman-Karber method and Reed and Muench method. To understand/apply the above formulas, moderate statistical/mathematical skills are necessary. In this paper, a simple formula/method for calculating 50% endpoints has been proposed. The formula yields essentially similar results as those of the Spearman-Karber method. The formula has been rigorously evaluated with several samples.
Citrate Anticoagulation during CVVH in High Risk Bleeding Patients (2007)

We developed a protocol for RCA during CVVH using commercially available replacement fluid that proved safe, flexible and applicable in an Intensive Care Unit (ICU) setting.
An Automated Controlled-Flow Air Infiltration Measurement System (1980)

A description is presented of an automated, controlled flow air infiltration measurement system. This system measures total air flow, a volume per unit time, due to infiltration in a test space. Data analysis is discussed and the mixing problem is analyzed. Different modes of operating the system are considered: (a) concentration decay, (b) continuous flow in a single chamber, and (c) continuous flow in a multichamber enclosure. Problems associated with the use of nitrous oxide as a tracer gas are described.
Flow-focused synthesis of monodisperse gold nanoparticles using ionic liquids on a microfluidic platform (2010)

A microfluidic device was used in tandem with an imidazolium-based ionic liquid to fabricate monodisperse gold nanoparticles (4.38 ± 0.53 nm) with excellent control over size and morphology.
Molecular dynamics simulations of the mechanical unfolding of proteins (2006)

A number of proteins perform load-bearing functions in living organisms and often have unique mechanical properties.In recent years, there has been considerable effort to understand the relationships between the molecular structure of such proteins and their mechanical response.Several of them have been studied in great detail through single molecule mechanical pulling experiments.Interpretation of these experiments requires the use of atomistic simulations.However typical simulation time scales are many orders of magnitude shorter than relevant experimental and/or physiological time scales.In this dissertation, we have developed a simulation methodology that provides a direct link between experiments and simulations and is capable of predicting the outcome of single molecule pulling experiments.By using this methodology, we have been able to understand the relationships between the molecular structure and the mechanical properties of a number of proteins.I report on our studies of the mechanical unfolding of the I27 domain of the muscle protein titin, ubiquitin, and protein G and compare them with the existing experimental data.The distribution of the unfolding force as well as its dependence on the pulling rate predicted by our simulations is found to be in good agreement with AFM experiments.We demonstrate that the mechanical unfolding pathway can be altered by changing the pulling geometry and that the presence of a hydrogen bonded clamp between terminal parallel strands of these domains is the key iv property that is responsible for their high mechanical stability.We have also extended our studies of single protein domains to protein dimers.Our replica-exchange molecular dynamics simulation study of the mechanical unfolding of a segment-swapped protein G dimer suggests that the mechanical resistance of a protein complex may be controlled not only by the mechanical stability of individual domains but also by the inter-chain interactions between domains.v
Cationic ring‐opening polymerization of tetrahydrofuran with boron, aluminum, and gallium tristriflate (1992)

Abstract Boron, aluminum, and gallium tristriflate are new effective catalysts for the polymerization of tetrahydrofuran (THF). High‐molecular‐weight polytetrahydrofuran (PTHF) was obtained in excellent yield in the bulk polymerization of THF at ambient temperature with all three catalysts. The PTHF samples were characterized and some of their thermodynamic and mechanical properties were investigated and discussed.
RECONSTITUTION OF ACTIVE TOBACCO MOSAIC VIRUS FROM ITS INACTIVE PROTEIN AND NUCLEIC ACID COMPONENTS (1955)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
Analysis of the degradation of PZT and SrBi<sub>2</sub>Ta<sub>2</sub>O<sub>9</sub> thin films with a reductive process (1997)

Abstract Electrical properties, crystal structure and composition were analyzed about ferroelectric PZT and SBT thin films with a reductive heat treatment. PZT films annealed in the atmosphere containing H2 turned into paraelectric, while SBT films were shorted. Ferroelectricity of these degraded films recovered by a subsequent anneal in oxygen. Oxygen content in PZT and SBT films decreased by the reductive heat treatment and was compensated by the subsequent anneal in oxygen. Residual hydrogen was also detected in reduced SBT films. The loss of ferroelectricity or short of capacitor would be due to the oxygen defects and the residual hydrogen in ferroelectric thin films. A TiN layer covering ferroelectric capacitors acted as an H2 barrier. Pt top electrode also played a role in preventing the reduction. This effect was enhanced by using a Pt electrode thicker than 300 nm and by anneal it at 600 °C.