gebhart/patrepeval huggingface dataset:
Mathematical Modeling of Free-Radical Polymerization Fronts (1997)

Frontal polymerization is a process in which a spatially localized reaction zone propagates into a monomer, converting it into a polymer. In the simplest case of free-radical polymerization, a mixture of a monomer and initiator is placed into a test tube. Upon reaction initiation at one end of the tube, a self-sustained thermal wave, in which chemical conversion occurs, develops and propagates through the tube. We develop a mathematical model of the frontal polymerization process and analytically determine the structure of the polymerization wave, the propagation velocity, maximum temperature, and degree of conversion of the monomer. Specifically, we examine their dependence on the kinetic parameters of the reaction, the initial temperature of the mixture, and the initial concentrations of the initiator and monomer. Our analytic results are in good quantitative agreement with both direct numerical simulations of the model and experimental data (on butyl acrylate polymerization), which are also presented in the paper.
Editorial (2016)

I would like to announce the special supplement of "Nuclear Medicine Review" which consists of case reports only.
ChemInform Abstract: Phenyllithium: Novel Metalation Agent for the Pyridine Ring. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Occlusive arterial thrombosis in cynomolgus monkeys with varying plasma concentrations of lipoprotein(a). (1993)

Lipoprotein(a) (Lp[a]) is a newly recognized risk factor for the development of coronary heart disease and stroke in human beings; however, the mechanisms by which Lp(a) increases the risk of coronary heart disease remain unclear. The purpose of this study was to examine the effects of Lp(a) on the occurrence of occlusive arterial thrombosis. Occlusive arterial thrombus formation was examined in 18 cynomolgus monkeys with high plasma Lp(a) concentrations (> 35 mg/dL, n = 6), intermediate Lp(a) concentrations (20-25 mg/dL, n = 6), and low Lp(a) concentrations (< 12 mg/dL, n = 6). A Goldblatt clamp was positioned around the left common carotid artery to produce a stenotic segment, and the artery was pinch-injured with needle holders. A 20-MHz Doppler velocity crystal, placed distal to the stenosis/injury site, was used to detect cyclic flow reductions (indicative of transient thrombosis) or permanent cessation of flow velocity (indicative of more stable occlusive thrombosis). All monkeys with high Lp(a) concentrations developed permanent cessation of flow, whereas only one of six arteries from low-Lp(a) monkeys developed permanent cessation of flow (p < 0.05). Arteries from monkeys with intermediate Lp(a) concentrations developed pronounced cyclic reductions of flow but did not progress to permanent cessation of flow. There were no differences in plasma von Willebrand factor activity among the three groups. Immunohistochemical analysis of the damaged arterial segments indicated incorporation of Lp(a) into the adventitia, media, and intima of arteries from monkeys with low and high plasma Lp(a) concentrations, as well as the presence of an occlusive thrombus in arteries that developed permanent cessation of flow.(ABSTRACT TRUNCATED AT 250 WORDS)
The dimensionality of the PRCA‐24: An explication of context dimensions (1988)

This article empirically addresses the dimensional structure of the PRCA‐24. Data from 656 respondents were factor analyzed and yielded inconclusive results for the most appropriate dimensional structure. The single factor solution most commonly espoused was viable; however, four specific characteristics of the data suggested an alternative underlying structure. An analysis of individual subject's patterns of context‐specific subscores revealed an interesting context effect that argues for treating the PRCA‐24 as a four dimensional assessment instrument.
KBM-3, an in vitro model of human acute myelomonocytic leukemia. (1992)

A human acute myelomonocytic leukemia cell line, KBM-3, was developed to study the pathophysiology of human acute myeloid leukemia. This cell line was characterized by morphology, immunophenotype, Giemsa-banding pattern, in vitro proliferation capacity, and tumorigenicity in nude mice. The KBM-3 cell line was established in the presence of exogenous lymphokines (human placenta-conditioned medium, HPCM), but medium for later passages did not contain HPCM. We found high cellular expression of the mRNA message for granulocyte-macrophage colony-stimulating factor (GM-CSF), which we suggest may be important for the immortalization of the cell line. KBM-3 cells have an immature myelomonocytic phenotype. Cytogenetic analysis revealed a pseudodiploid karyotype with five characteristic marker chromosomes and ranging in total number from 45 to 49. In suspension cultures, the cells had a doubling time of 23 h and a cloning efficiency of about 30% in soft agar independent of exogenous lymphokines. Two-thirds of nude mice injected with 1 x 10(4) KBM-3 cells and all animals injected with 1 x 10(5) cells developed S.C. granulocytic sarcomas within 6-8 weeks. These tumors were locally invasive but did not give rise to distant metastases. When transplanted to a new set of nude mice, all tumors formed secondary sarcomas at the site of implant. We conclude that the KBM-3 cell line may have value for studying the molecular events that underlie the neoplastic transformation in human myeloid leukemia.
Trends and advances in portable analytical instrumentation (1996)

The evolution of dedicated microcomputers and microcontrollers, in addition to silicon microfabrication and other micromachining technologies, and the integration of these technologies, is having a profound impact on both the functioning and the applications of analytical instrumentation. In essence, analytical instruments are moving from the domain of functioning as pure analyzers into the domain of functioning as problem solvers. This new functioning implies that the output from the new generation of instruments will not only be the analytical results but also the logical consequences that can be derived from the analytical data. The output from these devices will be decisions rather than analytical data. This has particularly important consequences for the vast expansion in applications for fieldable analytical chemistry. © 1996 John Wiley & Sons, Inc. Field Analyt Chem Technol 1: 87–92, 1996.
A PILOT-ASSISTED EQUALISATION SCHEME FOR THE UMTS-TDD DOWNLINK WITH PARTIAL LOADING (2005)

We address a pilot-assisted channel equalisation strategy for the partially loaded downlink time-division duplex (TDD) component of the universal mobile telecommunication system (UMTS). Adaptation is performed by minimising a hybrid cost function based on the constant modulus (CM) criterion for all active users and a mean square error (MSE) criterion for both absent users and pilot signals. Computer simulations are used to assess the performance of the equalisation strategy under various partially loaded conditions.
Microstructure evolution and electrical characterization of Lanthanum doped Barium Titanate (BaTiO3) ceramics (2016)

In the current work, we investigated the structural and dielectric properties of Lanthanum oxide (La2O3) doped Barium Titanate (BaTiO3) ceramics and established a correlation between them. Solid state sintering method was used to dope BaTiO3 with 0.3, 0.5 and 0.7 mole% La2O3 under different sintering parameters. The raw materials used were La2O3 nano powder of ~80nm grain size and 99.995% purity and BaTiO3 nano powder of 100nm grain size and 99.99% purity. Grain size distribution and morphology of fracture surface of sintered pellets were examined by Field Emission Scanning Electron Microscope and X-Ray Diffraction analysis was conducted to confirm the formation of desired crystal structure. The research result reveal that grain size and electrical properties of BaTiO3 ceramic significantly enhanced for small amount of doping (up to 0.5 mole% La2O3) and then decreased with increasing doping concentration. Desired grain growth (0.80-1.3 µm) and high densification (<90% theoretical density) were found by proper combination of temperature, sintering parameters and doping concentration. We found the resultant stable value of dielectric constant was 10000-12000 at 100-300 Hz in the temperature range of 30°-50° C for 0.5 mole% La2O3 with corresponding shift of curie temperature around 30° C. So overall this research showed that proper La3+ concentration can control the grain size, increase density, lower curie temperature and hence significantly improve the electrical properties of BaTiO3 ceramics.
A Sn–SnS–C nanocomposite as anode host materials for Na-ion batteries (2013)

A Sn–SnS–C nanocomposite is prepared by simply mechanically ball-milling Sn, SnS and C powders. In this composite, Sn nanocrystals are surface-coated with SnS nanoparticles and uniformly dispersed in the carbon matrix. During discharge, the SnS particles undergo an electrochemical conversion reaction to generate Sn and Na2S nanocrystals and then the Sn particles alloy with Na to produce the NaSn alloy. The conversion reaction of SnS and the alloying reaction of Sn with Na are completely reversible, producing a very high reversible Na-storage capacity of >600 mA h g−1 at an appropriate low potential of ∼0.7 V. Since the SnS phase provides an effective buffering matrix to alleviate the volumetric change of the Sn particles during Na insertion and extraction, and also serves as a separator to prevent the aggregation of the Sn nanoparticles, the Sn–SnS–C composite anode demonstrates a very good cycling stability with 87% capacity retention over 150 cycles, possibly usable for Na-ion batteries.
[Relationship between placenta growth factor and the pathogenesis of pregnancy induced hypertension syndrome]. (2001)

The abnormal expression of PLGF may play an important role in the pathogenesis of placental ischaemia hypoxia in PIHs.
Clonogenic cell assay for anchorage‐dependent squamous carcinoma cell lines using limiting dilution (1989)

Clonogenic assays under either anchorage-dependent or -independent conditions are very useful for testing the sensitivity of tumor cells to cytotoxic drugs and radiation. These assays have not been widely used with squamous-cell carcinomas (SCC) because of poor tumor-cell viability and poor cloning efficiency, especially in semi-solid media. To find a clonogenic assay suitable for use with human squamous cancers we tested SCC lines, derived in our laboratory from patients with head and neck cancer, for the capacity to form colonies in soft agar and in 96-well plates. Of 13 UM-SCC lines tested for colony formation in agarose, only UM-SCC-11A was capable of growth in conventional semi-solid media. One other line, UM-SCC-14C, produced colonies in agarose only in the presence of epidermal growth factor. In contrast, all 17 of the SCC lines tested exhibited colony formation in adherent cell culture using limiting dilution in 96-well plates. The plating efficiencies of the SCC lines in the 96-well plate assay ranged from 0.02 to 0.52 colonies (wells)/cell whereas the PE values in soft agar were lower, ranging from 0.0055 to 0.0086 colonies/cell. The 96-well plate assay is not affected by cell migration, a problem encountered with some cell lines when clonogenic assays are performed in Petri dishes. UM-SCC-11A was tested for radiation sensitivity both in soft agar and in the 96-well plate assay. Comparable results were obtained. In summary, the majority of SCC cell lines did not form viable colonies in soft agar but the 96-well plate assay was applicable to a broad spectrum of anchorage-dependent human SCC cell lines and provides an efficient method for evaluating clonogenic cell survival.
chong fen fa hui xuan ya shi yu lun ye li de zuo yong (1997)

旋压式渔线轮曳力的功能,是当大鱼上钩要线时,适时地放线,从而减轻竿、线和钩的负荷,保证渔具的安全。同时,亦消耗了鱼的体力,有利于遛鱼、抄鱼上岸。因此,正确地使用渔线轮的曳力并充分发挥其作用,是能否钓获大鱼的关键。
Performance Analysis Of a Combined Desiccant/Absorption Air-Conditioning System (1999)

In this paper the combination of an air desiccant system combined with an absorption system to develop a triple-effect system is analyzed. The advantage of the combination is to use off-the-shelf components. A thermodynamic design is performed to document the performance potential of a combined system. Multiple airflow arrangements are analyzed to determine optimum performance. The absorption system would provide heat removal capabilities (coolant effect) and the necessary regeneration energy required to regenerate the desiccant. The desiccant system would provide dehumidification capabilities. Four cases were analyzed to determine the optimum operating conditions of the desiccant/absorption system. The model predicted that the most efficient use of the system would result using outdoor air as the process air and return air for the regeneration. The four cases illustrated that the combined system needs to be integrated with the control scheme of the overall HVAC system to ensure operation near its optimum efficiency. This paper illustrates that a very attractive potential for the combination of these two systems exists which can be assembled with off-the-shelf components.
Exosomes for Intramyocardial Intercellular Communication (2015)

Cross-talk between different cell types plays central roles both in cardiac homeostasis and in adaptive responses of the heart to stress. Cardiomyocytes (CMs) send biological messages to the other cell types present in the heart including endothelial cells (ECs) and fibroblasts. In turn, CMs receive messages from these cells. Recent evidence has now established that exosomes, nanosized secreted extracellular vesicles, are crucial mediators of such messages. CMs, ECs, cardiac fibroblasts, and cardiac progenitor cells (CPCs) release exosomes carrying nonrandom subsets of proteins, lipids, and nucleic acids present in their cells of origin. Exosomes secreted from CMs are internalized by fibroblasts and regulate gene expression in these cells as well as in ECs. CPC-derived exosomes protect CMs against apoptosis while also stimulating angiogenesis. They are rich in cardioprotective and proangiogenic microRNAs such as miR-146, miR-210, and miR-132. When injected into infracted hearts in vivo, CPC-derived exosomes reduce infarct size and improve cardiac function. Thus, exosomes are emerging both as key mediators of intercellular communication in the heart and as therapeutic candidates for heart disease.
The best of the week’s health-related TV and radio (2009)

Our roundup of what's on.
A cryptochrome/photolyase class of enzymes with single-stranded DNA-specific photolyase activity (2006)

Photolyases and cryptochrome blue-light photoreceptors are evolutionarily related flavoproteins that perform distinct functions. Photolyases repair UV-damaged DNA in many species from bacteria to plants and animals. Cryptochromes regulate growth and development in plants and the circadian clock in animals. Recently, a new branch of the photolyase/cryptochrome family was identified. Members of this branch exhibited no or trace levels of DNA repair activity in vivo and in vitro and, therefore, were considered to be cryptochromes, and they were named cryptochrome-DASH. Here, we show that Cry-DASH proteins from bacterial, plant, and animal sources actually are photolyases with high degree of specificity for cyclobutane pyrimidine dimers in ssDNA.
Local convection-enhanced delivery of an anti-CD40 agonistic monoclonal antibody induces antitumor effects in mouse glioma models (2016)

Local delivery of FGK45 significantly prolonged survival in glioma stem cell models. Thus, local delivery of this monoclonal antibody is promising for immunotherapy against gliomas.
Liquid metal technology of synthesis of AlOOH anisotropic nanostructured aerogel (2017)

New method for production of aerogel nanostructures (using the example of AlOOH aerogel) with involvement of liquid metals is examined. In contrast with conventional sol–gel method for producing aerogels the role performed by the alcohol (aqueous) solution is played in the new method by liquid metal in which the base of the future aerogel structure dissociates and assembling of the nanostructure takes place within the gas phase covering the liquid metal. The latter obstacle fundamentally distinguishes the liquid metal method from the conventional technology of aerogel synthesis. Assembling the aerogel structure in the sol–gel method takes place as the result of removal of liquid phase at supercritical parameters which ultimately determines the cost of the products. In the liquid-metal method there is no need to remove the liquid phase, because assembling of fractal nanostructure occurs in the gas phase. Liquid-metal aerogel production method is realized at low (usually atmospheric) pressure without the need to use hazardous and corrosive reagents, and the heat released in the reaction is sufficient for maintaining the desired synthesis temperature. Results of studies of synthesis and properties of ultraporous aluminum oxyhydroxide Al2O3⋅n(H2O) (AlOOH aerogel) produced using the method of selective oxidation of Ga–Al and Bi–Al binary liquid metal fusions by water steam are presented in the present paper. Studies of aerogel properties were performed using methods of scanning electron microscopy (SEM), X-ray diffraction (XRD), synchronous differential scanning calorimetry and thermogravimetry (DSC/TG), as well as by energy dispersive X-ray (EDX) spectroscopy. It was established on the basis of the microstructure analysis performed that the aerogel has space-oriented fibrous nanostructure with “tensile” type anisotropy and fiber diameters varying from 5 nm to 15 nm. It follows from XRD studies that AlOOH aerogel remains to be amorphous up to 1000 °С. Results of studies of thermal physical properties of the aerogel and its elemental composition are presented. It was established that aerogel has low thermal conductivity (∼ 0.01–0.03 W/(m⋅K)) within rather wide temperature range from 130 to 1300 K.
Cell culture arrays using magnetic force-based cell patterning for dynamic single cell analysis (2007)

In order to understand the behavior of individual cells, single cell analyses have attracted attention since most cell-based assays provide data with values averaged across a large number of cells. Techniques for the manipulation and analysis of single cells are crucial for understanding the behavior of individual cells. In the present study, we have developed single cell culture arrays using magnetic force and a pin holder, which enables the allocation of the magnetically labeled cells on arrays, and have analyzed their dynamics. The pin holder was made from magnetic soft iron and contained more than 6000 pillars on its surface. The pin holder was placed on a magnet to concentrate the magnetic flux density above the pillars. NIH/3T3 fibroblasts that were labeled with magnetite cationic liposomes (MCLs) were seeded into a culture dish, and the dish was placed over the pin holder with the magnet. The magnetically labeled cells were guided on the surface where the pillars were positioned and allocated on the arrays with a high resolution. Single-cell patterning was achieved by adjusting the number of cells seeded, and the target cell was collected by a micromanipulator after removing the pin holder with the magnet. Furthermore, change in the morphology of magnetically patterned cells was analyzed by microscopic observation, and cell spreading on the array was observed with time duration. Magnetic force-based cell patterning on cell culture arrays would be a suitable technique for the analysis of cell behavior in studies of cell-cell variation and cell-cell interactions.
DeepGO: predicting protein functions from sequence and interactions using a deep ontology-aware classifier (2017)

Supplementary data are available at Bioinformatics online.
Effect of Monoterpene Vapors on the Western Pine Beetle (1965)

Journal Article Effect of Monoterpene Vapors on the Western Pine Beetle Get access Richard H. Smith Richard H. Smith Pacific Southwest Forest and Range Experiment Station Forest Service, USDA, Berkeley, California Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Economic Entomology, Volume 58, Issue 3, 1 June 1965, Pages 509–510, https://doi.org/10.1093/jee/58.3.509 Published: 01 June 1965 Article history Received: 08 October 1964 Accepted: 05 January 1965 Published: 01 June 1965
Motor-impaired touchscreen interactions in the wild (2014)

Touchscreens are pervasive in mainstream technologies; they offer novel user interfaces and exciting gestural interactions. However, to interpret and distinguish between the vast ranges of gestural inputs, the devices require users to consistently perform interactions inline with the predefined location, movement and timing parameters of the gesture recognizers. For people with variable motor abilities, particularly hand tremors, performing these input gestures can be extremely challenging and impose limitations on the possible interactions the user can make with the device. In this paper, we examine touchscreen performance and interaction behaviors of motor-impaired users on mobile devices. The primary goal of this work is to measure and understand the variance of touchscreen interaction performances by people with motor-impairments. We conducted a four-week in-the-wild user study with nine participants using a mobile touchscreen device. A Sudoku stimulus application measured their interaction performance abilities during this time. Our results show that not only does interaction performance vary significantly between users, but also that an individual's interaction abilities are significantly different between device sessions. Finally, we propose and evaluate the effect of novel tap gesture recognizers to accommodate for individual variances in touchscreen interactions.
Acute cholestasis induced by lithocholic acid in the rat. A freeze-fracture replica and thin section study. (1975)

Sodium lithocholate (LCA) was continuously infused intravenously (0.1 or 0.2 mumole per minute per 100 gm. body weight) in Wistar rats with a bile fistula for up to 4 hours. The higher dose induced complete cholestasis within 2 to 3 hours, whereas the low dose reduced the biliary output to less than 10 per cent of the preinfusion level by the 3rd hour. Ultrastructural changes which were primarily localized to the bile canaliculi and the pericanalicular region were seen 30 minutes after the onset of bile acid infusion. Dilation of the bile carnaliculi, loss of canalicular microvilli, prominence of the pericanalicular ectoplasm, and a characteristic lamellar transformation of the canalicular membrane developed, which became more prominent and widespread with progression of time. A freeze-fracture replica study revealed that the canalicular microvilli became transformed through widening and flattening into multilamellar foldings. Intramembranous granules of the canalicular membrane appeared to have become redistributed, being few or absent in the "transformed" regions. In addition, a sharply angulated, crystalline material was seen in occasional bile canaliculi. This material appeared as a negative image in thin sections, indicating its solubility in organic solvents which were used for dehydration. With the lower dose of LCA, subcellular changes were similar to, but less severe and which accompany an acute cholestasis induced by LCA is attributable to the accumulation of this compound in the bile canaliculus and its vicinity. LCA presumably causes an asymmetric perturbation in the molecular organization of the canalicular membrane which results in ultrastructural alterations and failure of fluid transport. In addition, precipitates of LCA appear to form in the bile canaliculi and may contribute to cholestasis.
CHAPTER V (2012)

A summary is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.