gebhart/patrepeval huggingface dataset:
Oxidized Membrane Vesicles and Blebs From Apoptotic Cells Contain Biologically Active Oxidized Phospholipids That Induce Monocyte-Endothelial Interactions (2002)

Membrane vesicles (MVs) released from activated cells and blebs from apoptotic cells are increased in patients with vascular disease and in those with atherosclerotic lesions, and their contribution to inflammatory reactions has been suggested. At sites of inflammation, MVs could serve as rapidly available substrates for peroxidation, carry oxidized compounds to activate other cells, and amplify inflammation. Here, we show that MVs released from tert-butyl hydroperoxide-treated endothelial cells (ECs) and apoptotic blebs, but not MVs from Ca(2+) ionophore-treated ECs, stimulate monocyte adhesion to ECs, an important step in atherogenesis. We show that oxidized phospholipids, such as the previously identified 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine (POVPC), are responsible for biological activity in MVs and apoptotic blebs. Natural antibodies from apolipoprotein E-null mice that recognize POVPC also recognize oxidized MVs, and pretreatment of MVs with these antibodies inhibits their ability to activate ECs. Furthermore, the biological activity of oxidized MVs is inhibited by platelet-activating factor receptor antagonists, which have been shown to inhibit the action of POVPC. Taken together, we show that oxidized MVs and apoptotic blebs stimulate ECs to specifically bind monocytes, with oxidized phospholipids (POVPC) being the active principle. In addition to oxidized lipoproteins, oxidized MVs and apoptotic blebs may play an important role in chronic inflammatory diseases, such as atherosclerosis.
MR‐guided biopsy: A review of current techniques and applications (2008)

Biopsy has become a cornerstone of modern medicine and most modern biopsies are performed percutaneously using image guidance, typically computed tomography or ultrasound. MR-guided biopsy offers many advantages over these more traditional modalities, and the recent development of interventional MR imaging techniques has made MR-guided percutaneous biopsies and aspirations a clinical reality. As the field of MR-guided procedures continues to expand and to attract more attention from radiologists, it is important to understand the concepts, techniques, applications, advantages, and limitations of MR-guided biopsy/percutaneous procedures. Radiologists should also recognize the need for their significant involvement in the technical aspects of MR-guided procedures, since several user-defined parameters can alter device visualization in the MR imaging environment and affect procedure safety. This article reviews the prerequisites, systems, and applications of MR-guided biopsy.
Molecular Vehicles for Mitochondrial Chemical Biology and Drug Delivery (2014)

The mitochondria within human cells play a major role in a variety of critical processes involved in cell survival and death. An understanding of mitochondrial involvement in various human diseases has generated an appreciable amount of interest in exploring this organelle as a potential drug target. As a result, a number of strategies to probe and combat mitochondria-associated diseases have emerged. Access to mitochondria-specific delivery vectors has allowed the study of biological processes within this intracellular compartment with a heightened level of specificity. In this review, we summarize the features of existing delivery vectors developed for targeting probes and therapeutics to this highly impermeable organelle. We also discuss the major applications of mitochondrial targeting of bioactive molecules, which include the detection and treatment of oxidative damage, combating bacterial infections, and the development of new therapeutic approaches for cancer. Future directions include the assessment of the therapeutic benefit achieved by mitochondrial targeting for treatment of disease in vivo. In addition, the availability of mitochondria-specific chemical probes will allow the elucidation of the details of biological processes that occur within this cellular compartment.
Bargaining for your privacy in the information age: Systematic factors undermining the equity of user-company online information transactions (2014)

Consumer privacy and protection of personal information are among the forefront of emerging complex social issues in the internet age. This growing threat to consumers' safety and security is framed as a systemic problem of structural inequality, specifically one where consumers are situated in positions of inferior bargaining power compared to the online service providers they engage in personal information transactions with. We propose a host of vestigial societal factors interacting with the turbulently transitional information-based economy, including outdated legal and economic regulations as well as cognitive limitations and cultural preferences among public users, reinforce and exacerbate these inequitable consumer-company relationships. Potential implications on future policy, social changes and directions for future research are discussed.
Paper-Based SlipPAD for High-Throughput Chemical Sensing (2013)

We report a paper analytical device (PAD) that is based on the SlipChip concept. This SlipPAD enables robust, high-throughput, multiplexed sensing while maintaining the extreme simplicity of paper-based analysis. The SlipPAD is comprised of two wax-patterned paper fluidic layers. By slipping one layer relative to the other, solutions wick simultaneously into a large array of sensing reservoirs or sequentially into a large array of channels to carry out homogeneous or heterogeneous assays, respectively. The applicability of the device to high-throughput multiplex chemical analysis is demonstrated by colorimetric and fluorescent assays.
gamma-aminobutyric Acid(A) (GABA(A)) agonist 4,5,6, 7-tetrahydroisoxazolo[4,5-c]pyridin-3-ol persistently increases sleep maintenance and intensity during chronic administration to rats. (2000)

Many hypnotics, such as benzodiazepines, are agonistic modulators of gamma-aminobutyric acid(A) (GABA(A)) receptors. Such compounds increase the ability to fall and stay asleep, but inhibit rapid-eye movement (REM) sleep and deep non-REM sleep. However, tolerance to their hypnotic action may develop rapidly. Previous findings in rats and humans demonstrate that the gamma-aminobutyric acid(A) agonist 4, 5,6,7-tetrahydroisoxazolo[4,5-c]pyridin-3-ol (THIP) promotes deep non-REM sleep and increases non-REM sleep continuity. To investigate the effects of repeated administration, we assessed sleep in rats before, during, and after chronic dosing of THIP (3 mg/kg, once daily for 5 days; n = 9) or of placebo (n = 8). The substances were administered i.p. at the onset of darkness. The electroencephalogram (EEG) and electromyogram were recorded during the first 6 h after injection. During baseline recording, the placebo and the THIP group exhibited similar sleep patterns. After the first THIP injection, rats displayed more non-REM sleep, longer non-REM episodes, and higher levels of slow wave activity in the EEG within non-REM sleep than the placebo group rats. The effects were sustained during all treatment days. REM sleep was not affected. After drug withdrawal, the sleep patterns of the THIP and the placebo group were practically identical again. These observations suggest that THIP does not rapidly produce tolerance toward its sleep effects and abrupt drug withdrawal may not be associated with sleep disturbances. These findings confirm and extend the existing information suggesting that THIP may be promising for treatment of insomnia.
A new dimension (2013)

Paul Morgan explores how 3-D printing is set to revolutionise the way components and even ships are built. Sidebars: Big Data can reshape the class of the future / [Howard Fireman] -- Shipistics : big data challenge / [Roger Adamson].
5-Heteroaryl-2'-deoxyuridine Analogs. Synthesis and Incorporation into High-Affinity Oligonucleotides (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT5-Heteroaryl-2'-deoxyuridine Analogs. Synthesis and Incorporation into High-Affinity OligonucleotidesArnold J. Gutierrez, Terry J. Terhorst, Mark D. Matteucci, and Brian C. FroehlerCite this: J. Am. Chem. Soc. 1994, 116, 13, 5540–5544Publication Date (Print):June 1, 1994Publication History Published online1 May 2002Published inissue 1 June 1994https://pubs.acs.org/doi/10.1021/ja00092a003https://doi.org/10.1021/ja00092a003research-articleACS PublicationsRequest reuse permissionsArticle Views532Altmetric-Citations97LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Platelets Play Differential Role During the Initiation and Progression of Autoimmune Neuroinflammation (2015)

Our study indicates differential roles for platelets in the regulation of functions of pathogenic CD4 T cells during initiation and progression of central nervous system autoimmune inflammation.
Using Cloud Computing to Implement a Security Overlay Network (2012)

This article proposes and analyzes a general cloud-based security overlay network that can be used as a transparent overlay network to provide services such as intrusion detection systems, antivirus and antispam software, and distributed denial-of-service prevention. The authors analyze each of these in-cloud security services in terms of resiliency, effectiveness, performance, flexibility, control, and cost.
Identifying e-business readiness factors contributing to IT distribution channel reseller success: a case analysis of two organizations (2003)

The purpose of the study is to identify whether certain factors have an impact on the success of organizations in the IT distribution channel to adopt and promote e-business strategic models to their end-user customers. Two reseller organizations participated in an in-depth set of surveys around e-business sales and distribution of IT products and services. A set of working research hypotheses was formulated for investigation. A survey instrument was developed, pre-tested and administered to thirteen executives in two reseller organizations. Managerially the findings were focused around the need to offer a differentiated set of e-business service offerings and to then decide how the organization should best develop partnering relationships and/or outsource the expertise. Outsourcing relationships, it was found, reduce the complexity of delivering overall e-business solutions, while also creating project management challenges. Strategic acquisitioning was a key factor in making e-business initiatives successful in the IT distribution channel.
Fe - Ni - B 계 비정질합금의 결정화 특성 (1993)

The crystallization characteristics of the Fe_(80-x)Ni_xB_(20)(20≤x≤40) and (Fe_(0.5)Ni_(0.5))_(80-x)Bx(16≤x≤24) amorphous alloy systems have been investigated in detail using differential scanning calorimetry, X-ray diffraction and transmission electron microscopy. Measurements of the exothermic peak temperature (T_p) and the activation energy during crystallization were obtained by differential scanning calorimetry. In the Fe_(80-x)Ni_xB_(20) amorphous alloys activation energy for crystallization increased with increasing x, and in the (Fe_(0.5)Ni_(0.5))_(100-x)B_x amorphous alloys it decreased with increasing x. Two-step crystallization was observed in specimens with x≤18 of (Fe_(0.5)Ni_(0.5)(100-x)B_x alloys; amorphous→amorphous＋γ-(FeNi)→γ-(FeNi)＋o-(FeNi)₃B. By the X-ray diffraction, the phases of crystallization products of these amorphous alloys are (ⅰ)fcc-(Fe,Ni), t-(Fe,Ni)₃B or fcc-(Fe,Ni), o-(fe,Ni)₃B, t-(Fe,Ni)₃B for high Fe content, (ⅱ)fcc-(Fe,Ni) and o-(Fe,Ni)₃B for equal contents of Fe and Ni, and (ⅲ)o-(Fe,Ni)₃B for high B content.
Angle gathers for RTM using extended imaging conditions (2010)

We can use extended imaging conditions in general, and the time lag imaging condition in particular, to compute angle gathers for reverse‐time migration (RTM). The transformation of time lags to angles was proposed previously by other authors; however, the proposed workflow requires a dip field and is increasingly inaccurate in areas with conflicting dips and for dips greater than 60°. In this paper, we propose methods to overcome the dip limitation and to do the angle transformation without explicitly using the dip field. We discuss the angular resolution present on these gathers and allude to the effects of acquisition geometry. We use a synthetic 2D model to compare results obtained using our proposed methods and the conventional workflow. Finally, we show RTM angle gathers for the SEAM model using our methods.
Integrated sensing for ionic polymer–metal composite actuators using PVDF thin films (2007)

Compact sensing methods are desirable for ionic polymer-metal composite (IPMC) actuators in microrobotic and biomedical applications. In this paper a novel sensing scheme for IPMC actuators is proposed by bonding an IPMC and a PVDF (polyvinylidene fluoride) thin film with an insulating layer in between. The insulating layer thickness is properly designed to minimize the stiffness of the composite IPMC/PVDF structure while reducing the electrical feedthrough coupling between the IPMC and PVDF. A distributed circuit model is developed to effectively represent the electrical coupling dynamics, which is then used in real-time compensation for extraction of the true sensing signal. Experimental results show that the developed IPMC/PVDF structure, together with the compensation algorithm, can perform effective, simultaneous actuation and sensing. As the first application, this sensori-actuator has been successfully used for performing and monitoring open-loop micro-injection of living Drosophila embryos. © IOP Publishing Ltd.
An extension of the database language SQL to capture more relational concepts (1988)

An extension of the database language SQL is described which introduces several new concepts into the language that are standard in the relational model, but surprisingly not present in available SQL-based systems such as SQL/DS and DB2.
Extracting business rules from COBOL: A model-based tool (2013)

This paper presents a Business Rule Extraction tool for COBOL systems. Starting from a COBOL program, we derive a model-based representation of the source code and we provide a set of model transformations to identify and visualize the embedded business rules. In particular, the tool facilitates the definition of an application vocabulary and the identification of relevant business variables. In addition, such variables are used as starting point to slice the code in order to identify business rules, that are finally represented by means of textual and graphical artifacts. The tool has been developed as an Eclipse plug-in in collaboration with IBM France.
OSNR and nonlinear noise power estimation for optical fiber communication systems using LSTM based deep learning technique (2018)

The optical signal-to-noise ratio (OSNR) and fiber nonlinearity are critical factors in evaluating the performance of high-speed optical fiber communication systems. Recently, several deep learning based methods have been put forward to monitor OSNR of a fiber communication system. In this work, we propose a long short-term memory (LSTM) network based method to simultaneously estimate OSNR and nonlinear noise power caused by fiber nonlinearity. In the training step, LSTM network extracts the essential features in frequency domain of the input signal. Then, with the built model in the training step, the LSTM output the OSNR and nonlinear noise power of the signal under test. The simulation by VPI software is carried on a 5-channel long haul optical transmission system with the launched optical power of -3.0~ + 3.0dBm per channel. The results show that the test error of OSNR is less than 1.0dB with the reference OSNR from 15 to 30dB for QPSK, 16QAM and 64QAM signal. The test error of nonlinear noise power is less than 1.0dB for QPSK and 16QAM signal when the Laser linewidth is 6 KHz and 100 KHz respectively. The proposed method is a promising candidate for nonlinearity-insensitive OSNR and accurate nonlinear noise power estimation in multi-channel long haul optical fiber communication systems.
Kinematic Magnetic Resonance Imaging for Evaluation of Patellar Tracking (1989)

In brief: Kinematic magnetic resonance imaging (MRI) of the patellofemoral joint was r developed to evaluate patellar tracking abnormalities. This technique has several advantages over radiography, eg, it does not expose the patient to ionizing radiation, and it clearly defines the patella and the femoral Cochlea groove without distortion. It also shows the movement of the patella in relation to the trochlea groove at 5° increments of knee flexion up to 30°. This case report demonstrates the value of kinematic MRI in diagnosing excessive lateral pressure syndrome (a frequent cause of knee pain), which cannot be detected by conventional diagnostic 'Paging techniques.
Conversation clusters (2009)

Conversation Clusters explores the use of visualization to highlight salient moments of live conversation while archiving a meeting. Cheaper storage and easy access to recording devices allows extensive archival. However, as the size of the archive grows, retrieving the desired moments becomes increasingly difficult. We approach this problem from a socio-technical perspective and utilize human intuition aided by computer memory. We present computationally detected topics of conversation as visual summaries of discussion and as reference points into the archive. To further bootstrap the system, humans can participate in a dialog with the visualization of the clustering process and shape the development of clustering models.
Hydrocarbon degrading potentials of bacteria isolated from Nigerian bitumen (Tarsand) deposit (2006)

In an effort at developing active microbial strains that could be of relevance in bioremediation of petroleum contaminated systems in Nigeria, fifteen hydrocarbon degrading bacteria and fungal species were isolated from three bitumen deposits. The predominant species belonged to the genera Pseudomonas and Aspergillus. The ability of Pseudomomnas stutzeri, Pseudomonas mullei and Alcaligenes sp. to degrade naphthalene, kerosene and diesel was studied. The results show maximal increase in optical densities and total viable counts concomitant with decrease in pH of the culture media. Typical generation times vary between 0.64 and 1.09 d, 0.97 and 3.03 d, 0.88 and 2.97 d respectively for kerosene, diesel and naphthalene. All the isolates utilized the hydrocarbons as sole carbon and energy sources equally well; there was no statistical difference (P > 0.05) in the utilization rates, thus suggesting close genetic similarities in respect of oil degradation capabilities. The study revealed for the first time, the types of microorganisms that are associated with Nigerian bitumen deposit and their potential to degrade oil. The knowledge of the potentials of these isolates to degrade hydrocarbons will increase the possibilities of developing models and strategies for removing hydrocarbon pollutants from the environment. (Nature and Science. 2006;4(3):51-57).
State Assignment for Finite State Machine Synthesis (2013)

This paper proposes simulated annealing based algorithm for the synthesis of a finite state machine to determine the optimal state assignment with less area and power dissipation. The algorithm has two annealing stages. In the first rough annealing stage it tries to search in global scope by the proposed rough search method. In the second focusing annealing stage it tries to search in local scope by using proposed focusing search methods intending changing solution slightly. In both stages, the experience of past solution is utilised by combing the best solution in the past and the current solution. The experiments performed on a large suite of benchmarks have established the fact that the proposed method outperforms the published GA-based algorithms. The results have shown the effectiveness of the proposed method in achieving optimal state assignment for finite state machine.
Elliptic-mode cavity for diode-pumped lasers (1991)

A novel laser resonator capable of producing a strongly elliptic TEM(00) mode in the gain medium is analyzed. Careful design results in an axially symmetric output beam, while the squeezed mode volume in the active medium allows an optimum exploitation of the inversion generated by end pumping the laser with a high-power laser-diode array. When a single array is used, the pump threshold can be typically reduced by an order of magnitude as compared with conventional (circular-mode) end-pumped systems without compromising any other laser characteristics. The combination of the presented cavity design with geometric multiplexing of diode arrays provides an efficient means for scaling end-pumped lasers to high powers.
A comparison of tactile, auditory, and visual feedback in a pointing task using a mouse-type device (1995)

A mouse was modified to add tactile feedback via a solenoid-driven pin projecting through a hole in the left mouse button. An experiment is described using a target selection task under five different sensory feedback conditions ('normal', auditory, colour, tactile, and combined). No differences were found in overall response times, error rates, or bandwidths; however, significant differences were found in the final positioning times (from the cursor entering the target to selecting the target). For the latter, tactile feedback was the quickest, normal feedback was the slowest. An examination of the spatial distributions in responses showed a peaked, narrow distribution for the normal condition, and a flat, wide distribution for the tactile (and combined) conditions. It is argued that tactile feedback allows subjects to use a wider area of the target and to select targets more quickly once the cursor is inside the target. Design considerations for human-computer interfaces are discussed.