gebhart/patrepeval huggingface dataset:
Mitochondrial Antibodies in Primary Biliary Cirrhosis: Species and Nonspecies Specific Determinants of M2 Antigen (1985)

Sera from patients with primary biliary cirrhosis reacted with four major bands in beef heart mitochondria and ATPase extract when analyzed by immunoblot after sodium dodecyl sulfate-polyacrylamide gel electrophoresis. These four immunologically reactive bands corresponded to protein bands with molecular weights of about (a) 80,000; (b) 63,000; (c) 56,000; and (d) 43,000 to 46,000. An additional immunoreactive band was found with some high-titered primary biliary cirrhosis sera at 36,000. No association with any ATPase subunits was found, except for band c which migrated between the alpha- and beta-subunit of ATPase. Most ATPase fractions did not contain this band c, indicating that M2 determinants, as defined by immunoblot, are not identical with any ATPase subunit. Species and nonspecies-specific determinants of M2 were identified using mitochondria from rat liver and human heart and liver. Antigenic bands a, c and d were nonspecies-specific. Band b and e occurred only in beef heart. An additional determinant at about 38,000 was detected using human heart and liver mitochondria. Primary biliary cirrhosis sera showed a typical reaction with two protein bands of Escherichia coli, one at about 85,000 to 90,000 and the other at 60,000. Antibodies against both determinants could be absorbed with submitochondrial particles of beef heart showing that E. coli shares cross-reacting determinants with mitochondria. Sera from 56 primary biliary cirrhosis patients were tested using beef heart mitochondria.(ABSTRACT TRUNCATED AT 250 WORDS)
The genome organization of banana bunchy top virus: analysis of six ssDNA components (1995)

We have cloned, sequenced and analysed an additional five circular ssDNA components of banana bunchy top virus (BBTV) which we have called components 2, 3, 4, 5 and 6. These components were present in all BBTV infections tested. Four of these components (components 3, 4, 5 and 6) had one large open reading frame (ORF) in the virion sense located 3' of a stem-loop structure. Each ORF had a potential TATA box and one or two potential polyadenylation signals associated with it and each polyadenylation signal had an associated GC-rich region containing the trinucleotide sequence TTG. A number of ORFs were identified in component 2 but none of these had appropriately located potential TATA boxes and polyadenylation signals associated with them. None of the ORF amino acid sequences nor the full DNA sequences of any of the components had significant sequence identity with any known protein or nucleic acid sequences. However, the ORF of component 4 encoded a 30 residue hydrophobic domain which may indicate that this ORF encoded a transmembrane protein. Further, the ORFs of components 3 and 5 potentially encoded proteins of about 20 kDa, the size of the BBTV coat protein. There were two regions of sequence identity between the five components described here and the previously described component 1. Each component contained a conserved stem-loop structure and a nonanucleotide potential TATA box which was 5' of the large virion-sense ORF in five of the components. The stem-loop structures were incorporated in a common region (CR-SL) of 69 nucleotides which was 62% identical between components. All six BBTV components also contained a major common region (CR-M) which was located 5' of the CR-SL in each component, in the non-coding region and was 76% identical over 92 nucleotides. Each CR-M contained a near-complete 16 nucleotide direct repeat and a GC-box which was similar to the rightward promoter element found in wheat dwarf geminivirus. From these results, BBTV appears to belong to an undescribed plant virus group which could also include subterranean clover stunt virus, coconut foliar decay virus, faba bean necrotic yellows virus and milk vetch dwarf virus.
A hybrid quantum–classical neural network with deep residual learning (2021)

Inspired by the success of classical neural networks, there has been tremendous effort to develop classical effective neural networks into quantum concept. In this paper, a novel hybrid quantum-classical neural network with deep residual learning (Res-HQCNN) is proposed. We firstly analyse how to connect residual block structure with a quantum neural network, and give the corresponding training algorithm. At the same time, the advantages and disadvantages of transforming deep residual learning into quantum concept are provided. As a result, the model can be trained in an end-to-end fashion, analogue to the backpropagation in classical neural networks. To explore the effectiveness of Res-HQCNN , we perform extensive experiments for quantum data with or without noisy on classical computer. The experimental results show the Res-HQCNN performs better to learn an unknown unitary transformation and has stronger robustness for noisy data, when compared to state of the arts. Moreover, the possible methods of combining residual learning with quantum neural networks are also discussed.
A Critical Comparison Between Distributed Database Approach and Data Warehousing Approach (2014)

Abstract—Distributed database system and data warehouse are used to analyze data for decision support. There are some similarity between distributed database and data warehouse. However, the Concepts of federated database systems are confusing with the concepts of data warehouse. But they are quite different. There is a debate which approach is better for decision support. It actually depends on the types of business and information required by the business.
Digital background calibration of a 0.4-pJ/step 10-bit pipelined ADC without PN generator in 90-nm digital CMOS (2008)

In nanometer digital CMOS, the linearity of pipelined A/D converters (ADCs) is degraded by the low dc gains of the opamps. Gain-enhancement techniques significantly increase the analog-circuit design complexity at low power and low voltage. Therefore, even in medium-resolution applications, digital background calibration is attractive for designing power-efficient ADCs. A simple, yet accurate, digital background calibration technique, which does not require a pseudo-random (PN) calibration signal, is proposed to minimize the power dissipation in the digital calibration unit. It achieves the same convergence speed and accuracy as PN-based techniques in 2-path (split) pipelined ADCs. A 10-bit 44-MS/s pipelined ADC, fabricated in a standard 1.2-V 90-nm digital CMOS process, uses the proposed calibration technique to achieve a 58.7-dB SNDR for a 21.5-MHz input, with a figure-of-merit (FOM) of 0.4 pJ/step.
Quality of life changes following inpatient and outpatient treatment in obsessive-compulsive disorder: a study with 12 months follow-up (2013)

The results indicate that persons with OCD suffer from a very low QoL. The QoL was significantly improved after 12 months of intensive state-of-the-art treatment. However, the QoL indices remained considerably lower than population norm values, indicating the need for additional research into novel treatment options for persons with OCD.
Pharmacological Potential of PDE5 Inhibitors for the Treatment of Cystic Fibrosis (2012)

Cystic Fibrosis -Renewed Hopes Through Research 414 in clinical use for the treatment of erectile dysfunction and/or of pulmonary arterial hypertension, rescue F508del-CFTR trafficking
Increasing yeast secretion of heterologous proteins by regulating expression rates and post‐secretory loss (2008)

Heterologous protein secretion involves the coupled processes of protein synthesis, protein folding, and secretory trafficking. A more complete understanding of how these processes interrelate could help direct optimization of secretion systems. Here we provide a detailed study regarding the dynamics of heterologous protein secretion from yeast in terms of intracellular protein levels, secreted protein levels, and unfolded protein response (UPR). Three different protein expression induction temperatures (20, 30, and 37 degrees C) were investigated as a means to modulate expression rates and thus cellular responses. Inducing at 20 degrees C yielded the slowest initial secretion rate, but the highest absolute level of product. Correspondingly, the level and the rate of both intracellular protein accumulation and unfolded protein response (UPR) activation were also the lowest at 20 degrees C. In addition, secretion ceased after approximately 22 h at 30 and 37 degrees C, respectively, while it was continuous until nutrient depletion at 20 degrees C. Maxima in secretion levels were observed that were a result of the additive effects of secretion cessation and post-secretory protein loss. The post-secretory loss of protein did not appear to result from solution phase proteolysis or aggregation, but required the presence of yeast cells. Refeeding of both yeast nitrogen base and casamino acids successfully prevented the post-secretory loss of protein at both high (37 degrees C) and low (20 degrees C) temperatures, and further increased secretion levels 1.5-fold at 20 degrees C where the secretory pathway was still functioning. Taken together, these findings suggest that there exists an appropriate balance between protein synthesis, processing and secretion rates required for secretion optimization.
Low damage, highly anisotropic dry etching of SiC (2002)

A parametric study of the etching characteristics of 6H p/sup +/ and n/sup +/ SiC and thin film SiC/sub 0.5/N/sub 0.5/ in Inductively Coupled Plasma NF/sub 3//O/sub 2/ and NF/sub 3//Ar discharges has been performed. The etch rates in both chemistries increase monotonically with NF/sub 3/ percentage and rf chuck power. The etch rates go through a maximum with increasing ICP source power, which is explained by a trade-off between the increasing ion flux and the decreasing ion energy. The anisotropy of the etched features is also a function of ion flux, ion energy and atomic fluorine neutral concentration. Indium-tin-oxide (ITO) masks display relatively good etch selectivity over SiC (maximum of /spl sim/70:1), while photoresist etches more rapidly than SiC. The surface roughness of SiC is essentially independent of plasma composition for NF/sub 3//O/sub 2/ discharges, while extensive surface degradation occurs for SiCN under high NF/sub 3/:O/sub 2/ conditions.
A new playing field for all non-profits. (2000)

Since the turn of the century, fund raising and consulting practices have changed little in a field defined by slow evolution, low technological advances, labor-intensive practices and relatively expensive time/resource requirements. Almost instantly, the Internet has "leveled the playing field" for all non-profits--allowing small organizations to take advantage of the same premier fund-raising expertise and services once available exclusively to large non-profits with significant resources and budgets.
Space groups <i>P</i>1 and <i>Cc</i>: how are they doing? (2009)

A survey of recent entries in the Cambridge Structural Database suggests that the percentage of structures described in space groups of inappropriately low symmetry has decreased from about 10% in the early 2000s to less than 5% today for space group Cc, but that for space group P1 it remains close to 8%.
An oversampling converter for strain gauge transducers (1992)

An oversampling converter that directly digitizes low-level strain gauge transducer outputs is presented. An instrumentation amplifier and two independent chopper-stabilized delta-sigma modulators amplify and convert the transducer's output and excitation. Digital division of the two independent conversions produces a 20-b ratiometric measurement. Drift due to external thermocouple junctions and RF rectification is eliminated by AC excitation of the transducer. Interference (50/60 Hz) is eliminated by a digital FIR filter that has a -3 dB bandwidth of 15 Hz. Offset and gain errors are corrected by digital calibration. The input-referred noise of this converter is 150 nV/sub rms/ and the linearity is 110 dB. The converter gain and offset drifts are less than 2.5 p.p.m./ degrees C and 15 nV/ degrees C, respectively. This 2- mu m CMOS chip consumes 30 mW of power and has an area of 25.5 mm/sup 2/.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Low temperature burnable CNT paste component for CNT-field emitter backlight unit (2004)

New component of CNT paste is explored to develop a carbon nanotube field emitter backlight unit (CNT-FE BLU) by screen printing method. To reduce the remnant of organic binder materials on the surface of SWCNT, P(MMA-co-BMA) random block copolymer as the new binder materials is developed. The weight of the remnant materials after burning process at 350/spl deg/C was measured by TGA. The measured field emission property demonstrated that the developed P(MMA-co-BMA) was effective to reduce the remnant on surface of CNT, which is critically important for improving the field emission property of CNT-FE BLU fabricated by screen printing method.
A Cannula for Simultaneous Drainage of Both Cavae in Artificial Heart Experiments. (1950)

SummaryA single cannula which can be tied in place to divert the entire flow of both the superior and inferior vena cava has been described. This cannula has been useful in experiments in which an extracorporeal pump or artificial heart has been employed.
Intermittent Catheterization the Right Way! (Volume vs. Time-Directed) (1996)

Intermittent catheterization (ICP) is a well-proven effective means of urologic management for spinal cord diseased (SCD) persons who meet the following criteria: adequate low pressure bladder capacity (350-400 cc minimum), adequate hand function, unobstructed urethra and compliant, understanding, continent, cooperative patients. Time-directed (Q4 H-Q6 H), ICP-obtained volumes on twenty-one patients revealed a majority of early, unnecessary as well as some late over-distended bladder catheterizations. The PCI 5000 or "Bladder Manager", a miniaturized ultrasonic bladder volume measuring device developed by Diagnostic Ultrasound of Seattle, was evaluated. It allowed the patients to perform volume-directed ICP which results in less frequent catheterizations and prevents bladder overdistension.
Devlet Kurma Sürecinde Samanoğulları (2003)

The Appearance of the Samanids State. The Sanunid dynasty appeared i Transoxiana in 1Xth century. The dynasty was attributed LO their ancestor. Saman. Their influence and/ame began LO increase with the period Bilindii gibi internet
Vertical distribution of dust in the stratosphere (1967)

Vertical distribution of stratospheric dust to determine total meteoric dust influx over earth surface
Modern floorplanning based on B/sup */-tree and fast simulated annealing (2006)

Unlike classical floorplanning that usually handles only block packing to minimize silicon area, modern very large scale integration (VLSI) floorplanning typically needs to pack blocks within a fixed die (outline), and additionally considers the packing with block positions and interconnect constraints. Floorplanning with bus planning is one of the most challenging modern floorplanning problems because it needs to consider the constraints with interconnect and block positions simultaneously. In this paper, the authors study two types of modern floorplanning problems: 1) fixed-outline floorplanning and 2) bus-driven floorplanning (BDF). This floorplanner uses B/sup */-tree floorplan representation based on fast three-stage simulated annealing (SA) scheme called Fast-SA. For fixed-outline floorplanning, the authors present an adaptive Fast-SA that can dynamically change the weights in the cost function to optimize the wirelength under the outline constraint. Experimental results show that this floorplanner can achieve 100% success rates efficiently for fixed-outline floorplanning with various aspect ratios. For the BDF, the authors explore the feasibility conditions of the B/sup */-tree with the bus constraints, and develop a BDF algorithm based on the conditions and Fast-SA. Experimental results show that this floorplanner obtains much smaller dead space for the floorplanning with hard/soft macro blocks, compared with the most recent work. In particular, this floorplanner is more efficient than the previous works.
Feasibility and safety of focused ultrasound-enabled liquid biopsy in the brain of a porcine model (2020)

Although blood-based liquid biopsy is a promising noninvasive technique to acquire a comprehensive molecular tumor profile by detecting cancer-specific biomarkers (e.g. DNA, RNA, and proteins), there has been limited progress for brain tumor application partially because the low permeability of the blood-brain barrier (BBB) hinders the release of tumor biomarkers. We previously demonstrated focused ultrasound-enabled liquid biopsy (FUS-LBx) that uses FUS to increase BBB permeability in murine glioblastoma models and thus enhance the release of tumor-specific biomarkers into the bloodstream. The objective of this study was to evaluate the feasibility and safety of FUS-LBx in the normal brain tissue of a porcine model. Increased BBB permeability was confirmed by the significant increase (p = 0.0053) in K<sup>trans</sup> (the transfer coefficient from blood to brain extravascular extracellular space) when comparing the FUS-sonicated brain area with the contralateral non-sonicated area. Meanwhile, there was a significant increase in the blood concentrations of glial fibrillary acidic protein (GFAP, p = 0.0074) and myelin basic protein (MBP, p = 0.0039) after FUS sonication as compared with before FUS. There was no detectable tissue damage by T<sub>2</sub><sup>*</sup>-weighted MRI and histological analysis. Findings from this study suggest that FUS-LBx is a promising technique for noninvasive and localized diagnosis of the molecular profiles of brain diseases with the potential to translate to the clinic.
Studies on Fused 2(1<i>H</i>)-Pyridenethiones: New Routes for the Synthesis of Fused 1<i>H</i>-Pyrazolo[3,4-<i>b</i>]pyridines and Fused Thieno[2,3-<i>b</i>]pyridines (1992)

Abstract A synthesis of fused 1H-pyrazolo[3,4-b]pyridines and fused thieno[2,3-b]pyridines utilizing fused 2(1H)-pyridinethiones as starting components is described. The structures of the products were assigned and confirmed on the basis of their elemental analysis and spectral data.
Potent Antiviral Activity of Topoisomerase I and II Inhibitors against Kaposi's Sarcoma-Associated Herpesvirus (2011)

The lytic DNA replication of Kaposi's sarcoma-associated herpesvirus (KSHV) initiates at an origin (ori-Lyt) and requires trans-acting elements, both viral and cellular. We recently demonstrated that several host cellular proteins, including topoisomerases I and II (Topo I and II), are involved in KSHV lytic DNA replication (Y. Wang, H. Li, Q. Tang, G. G. Maul, and Y. Yuan. J. Virol. 82: 2867-2882, 2008). To assess the importance of these topoisomerases in viral lytic replication, shRNA-mediated gene silencing was used. Depletion of Topo I and II severely inhibited viral lytic DNA replication as well as virion production, suggesting essential roles of these cellular proteins in viral DNA replication. The discovery of Topo I and II as enzymes indispensable for KSHV DNA replication raises a possibility that these cellular proteins could be new targets of therapeutic approaches to halt KSHV replication and treat KSHV-associated diseases. In this report, we examined one Topo I inhibitor and several Topo II inhibitors (inclusive of Topo II poison and catalytic inhibitors) as potential therapeutic agents for blocking KSHV replication. The Topo II catalytic inhibitors in general exhibited marked inhibition on KSHV replication and minimal cytotoxicity. In particular, novobiocin, with the best selectivity index (SI = 31.62) among the inhibitors tested in this study, is effective in inhibiting KSHV DNA replication and virion production but shows little adverse effect on cell proliferation and cycle progression in its therapeutic concentration, suggesting its potential to become an effective and safe drug for the treatment of human diseases associated with KSHV infection.
Construction of an Ortholog Database Using the Semantic Web Technology for Integrative Analysis of Genomic Data (2015)

Recently, various types of biological data, including genomic sequences, have been rapidly accumulating. To discover biological knowledge from such growing heterogeneous data, a flexible framework for data integration is necessary. Ortholog information is a central resource for interlinking corresponding genes among different organisms, and the Semantic Web provides a key technology for the flexible integration of heterogeneous data. We have constructed an ortholog database using the Semantic Web technology, aiming at the integration of numerous genomic data and various types of biological information. To formalize the structure of the ortholog information in the Semantic Web, we have constructed the Ortholog Ontology (OrthO). While the OrthO is a compact ontology for general use, it is designed to be extended to the description of database-specific concepts. On the basis of OrthO, we described the ortholog information from our Microbial Genome Database for Comparative Analysis (MBGD) in the form of Resource Description Framework (RDF) and made it available through the SPARQL endpoint, which accepts arbitrary queries specified by users. In this framework based on the OrthO, the biological data of different organisms can be integrated using the ortholog information as a hub. Besides, the ortholog information from different data sources can be compared with each other using the OrthO as a shared ontology. Here we show some examples demonstrating that the ortholog information described in RDF can be used to link various biological data such as taxonomy information and Gene Ontology. Thus, the ortholog database using the Semantic Web technology can contribute to biological knowledge discovery through integrative data analysis.
Pollock's textbook of cardiovascular disease and rehabilitation (2008)

Chapter 1. The History of Cardiovascular Rehabilitation Chapter 2. Epidemiology of Disease Chapter 3. Exercise as a Medicine Chapter 4. Multifactorial Risk Factor Intervention Chapter 5. Clinical Practice Guidelines and Target Outcomes Chapter 7. Role of the Inflammatory Process in Atherosclerosis Chapter 8. Clinical Exercise Testing Chapter 15. Endurance Training Chapter 16. Strength Training Chapter 17. Flexibility Training Chapter 32. Chronic Heart Failure Chapter 33. Cardiac Transplant Chapter 34. Thromboembolism / DVT.
An Enhancement Layer for ACELP Coder (2006)

This paper presents an enhancement layer coming on top of G.729 Annex A codec. This enhancement layer consists of an optimization of the algebraic fixed codebook pulses that were selected by the Annex A codec during the fixed codebook search. The pulses selected by the ACELP codec have all the same absolute amplitude. Our method optimizes each of these amplitudes in order to increase the quality. This is a low-complexity method that allows the introduction of an intermediate bitrate in ACELP-based scalable coder. On top of this pulse optimization method that requires 1.6 kbit/s we introduce a second fixed codebook search with a limited number of pulses (2) and a bitrate of 2.4 kbit/s