gebhart/patrepeval huggingface dataset:
Abstract 15843: A Novel Role for Telomerase in Calcific Aortic Valve Disease (2020)

Introduction: Calcific aortic valve disease (CAVD) is a disorder characterized by the slow, but a progressive thickening of the aortic valve leaflet that develops into severe calcification. The only current therapy is aortic valve replacement. Telomerase is an enzymatic complex best known for its telomere-extending activities on the ends of chromosomes yet, the catalytic subunit (TERT) has been implicated in multiple non-canonical transcriptional and epigenetic activities, including priming of mesenchymal stem cells (MSCs) to differentiate into osteoblasts, and transcriptional regulation of inflammatory genes. Hypothesis: We hypothesize that non-canonical TERT activity contributes to the progression of CAVD. Methods: We performed biochemical assays to study the role of TERT in the calcification process using primary tissues and valve interstitial cells (VICs) from control and CAVD patients, smooth muscle cells (SMCs) from WT and Tert knockout mice, and mesenchymal stem cells (MSCs). Results: We found that TERT protein is highly expressed in calcified aortic valves and VICs isolated from patients with calcified valves, compared to healthy valves. VICs can be induced to calcify under osteogenic differentiation conditions, and we found that TERT accumulated after fourteen days in this culture, with no effect on either telomere length, proliferation, or senescence. We expanded the scope of our approach by evaluating TERT's influence on calcification of mice aortic smooth muscle cells (mSMCs). We found WT mSMCs readily calcified in vitro, but mSMCs from Tert knockout mice did not, and Tert deletion also reduced valve calcification in a Ldlr / Tert double knockout mice model compared to Ldlr knockout alone. In VICs, shRNA mediated TERT downregulation reduced expression of RUNX2 . Finally, we found that inflammatory signals intensify in vitro calcification, induce TERT expression, and we show evidence that TERT interacts with STAT5. Conclusion: Our data suggest that TERT is required for valve calcification by stimulating transcriptional pathways promoting the osteogenic transition of quiescent VICs into calcifying VICs in the aortic valve. These results indicate that TERT is an active contributor to the calcification process of valve tissues.
Usefulness of the Scale for the Assessment and Rating of Ataxia (SARA) in Ataxic Stroke Patients (2011)

SARA corresponds well with gait status and ADL dependency in ataxic stroke patients and is considered to be a useful functional measure in that patient group.
Sytare: A Lightweight Kernel for NVRAM-Based Transiently-Powered Systems (2018)

In a near future, energy harvesting is expected to replace batteries in ultra-low-power embedded systems. Research prototypes of such systems have recently been proposed. As the power harvested in the environment is very low, such systems need to cope with frequent power outages. They are referred to as transiently-powered systems (TPS). In order to execute non-trivial applications, TPS need to retain information between power losses. To achieve this goal, emerging non-volatile memory (NVM) technologies are a key enabler: they provide a lightweight solution to retain, between power outages, the state of an application and of its peripheral devices. These include sensors, serial interface or radio devices for instance. Existing works have described various checkpointing mechanisms to adapt embedded applications to TPS but the use of peripherals was not yet handled. in these works. This paper proposes a solution for embedded applications using any peripheral device to run despite transient power. We follow a kernel-oriented approach resulting in minimal impact on the programming model of the application. We implement the new concepts in our lightweight kernel called Sytare, running on an MSP430FR5739 micro-controller and we analyze the cost of the proposed solution.
SOX2 Regulates YAP1 to Maintain Stemness and Determine Cell Fate in the Osteo-Adipo Lineage (2013)

The osteoblastic and adipocytic lineages arise from mesenchymal stem cells (MSCs), but few regulators of self-renewal and early cell-fate decisions are known. Here, we show that the Hippo pathway effector YAP1 is a direct target of SOX2 and can compensate for the self-renewal defect caused by SOX2 inactivation in osteoprogenitors and MSCs. Osteogenesis is blocked by high SOX2 or YAP1, accelerated by depletion of either one, and the inhibition of osteogenesis by SOX2 requires YAP1. SOX2 favors adipogenesis and induces PPARγ, but adipogenesis can only occur with moderate levels of YAP1. YAP1 induction by SOX2 is restrained in adipogenesis, and both YAP1 overexpression and depletion inhibit the process. YAP1 binds β-catenin and directly induces the Wnt antagonist Dkk1 to dampen pro-osteogenic Wnt signals. We demonstrate a Hippo-independent regulation of YAP1 by SOX2 that cooperatively antagonizes Wnt/β-catenin signals and regulates PPARγ to determine osteogenic or adipocytic fates.
Design, integration, and trade-off analyses of gasoline-fueled polymer electrolyte fuel cell systems for transportation. (1998)

Prototype fuel-cell-powered vehicles have recently been demonstrated in Japan, Europe, and North America. Conceptual designs and simulations of fuel-cell-powered vehicles have also been published [1-3]. Many of these simulations include detailed vehicle performance models, but they use relatively simplistic fuel-cell power system models. We have developed a comprehensive model of a polymer electrolyte fuel cell (PEFC) power system for automotive propulsion. This system simulation has been used to design and analyze fuel-cell systems and vehicles with gasoline (or other hydrocarbons) as the on-board fuel. The major objective of this analysis is to examine the influence of design parameters on system efficiency and performance, and component sizes.
Low power current-mode second-order bandpass IF filter (1997)

A controlled active inductance implemented from two current-controlled conveyors in conjunction with one capacitor is introduced. Calculation, taking all the parasitics of the conveyors into account, shows that with this design the phase deviation from ideal is pushed up to very high frequency. A second order bandpass filter operating in current-mode has been implemented from this controlled inductance. This filter exhibits two bandpass outputs. One has unity gain and the other, which can be used for Q-tuning purpose, has a magnitude-gain at f/sub 0/ directly proportional to the Q-factor. An integrated circuit prototype of an IF receiver stage for the GSM cellular telephone has been designed from two cascaded identical second-order bandpass cells above. This circuit, which is intended to replace a surface acoustic wave (SAW) filter, was centered at 85 MHz. Simulation and measurement results are given for this prototype. They show interesting performances in conjunction with very low power consumption: less than 38 mW for the entire IF stage under /spl plusmn/2.5 V supply.
Selective ethane ammoxidation to acetonitrile on alumina-supported niobium–antimony oxides (1991)

Acetonitrile can be synthesized from ethane by heterogeneous catalytic ammoxidation using Nb–Sb mixed oxides supported on alumina; a new type of (amm)oxidation active site on the catalyst, which can lead to a selective insertion of O–N atoms on the double bond of the intermediate ethylene is suggested.
A vision for heart rate health through wearables (2016)

Wearable technology has great potential for helping members of the public monitor their health. We are interested in medical conditions that can be monitored using the sensors on wearable devices like the Apple Watch. We are interested in the insights that can be provided by the monitoring of a person's heart rate. We have conducted interviews with doctors to understand what can be learned about the health of an individual via their heart rate and how we can use that information to design applications that aid in monitoring these conditions. In this paper, we explore this design space and identify the applications we will develop to help users track these conditions in considerably less invasive ways than current methods.
THE REVERSIBILITY OF SUBITANEOUS AND DIAPAUSE EGG PRODUCTION BY INDIVIDUAL FEMALES OF<i>LABIDOCERA AESTIVA</i>(COPEPODA: CALANOIDA) (1982)

In Vineyard Sound, Massachusetts the calanoid copepod,Labidocera aestiva undergoes a period of facultative diapause that is induced by short daylength photoperiods. This study examines egg production by individual females. It is shown that some, if not all, females can switch the type(s) of egg produced. The results indicate that in Vineyard Sound females adjust to the decreasing daylengths experienced during the fall by switching production from subitaneous to diapause eggs. I suggest that a female is triggered to switch the type of eggs produced after perceiving a specific number of short daylength photoperiods. The conversion is not instantaneous, however, and during this transition phase a female produces both subitaneous and diapause eggs. It is suggested that the reproductive capacity of the population is enhanced by this type of flexible diapause response.
Conjugation to the Cell-Penetrating Peptide TAT Potentiates the Photodynamic Effect of Carboxytetramethylrhodamine (2011)

Together, these results suggest that TAT can convert an innocuous fluorophore such as TMR into a potent photolytic agent. This effect involves the targeting of the fluorophore to cellular membranes and the production of singlet oxygen within the hydrophobic environment of the membranes. Our findings may be relevant for the design of reagents with photo-induced endosomolytic activity. The photocytotoxicity exhibited by TMR-TAT also suggests that CPP-chromophore conjugates could aid the development of novel Photodynamic Therapy agents.
Catalytic Dimerization of Propene by Nickel-Phosphine Complexes in 1-Butyl-3-methylimidazolium Chloride/AlEtxCl3-x (x = 0, 1) Ionic Liquids (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCatalytic Dimerization of Propene by Nickel-Phosphine Complexes in 1-Butyl-3-methylimidazolium Chloride/AlEtxCl3-x (x = 0, 1) Ionic LiquidsYves Chauvin, Sandra Einloft, and Helene OlivierCite this: Ind. Eng. Chem. Res. 1995, 34, 4, 1149–1155Publication Date (Print):April 1, 1995Publication History Published online1 May 2002Published inissue 1 April 1995https://pubs.acs.org/doi/10.1021/ie00043a017https://doi.org/10.1021/ie00043a017research-articleACS PublicationsRequest reuse permissionsArticle Views1041Altmetric-Citations148LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The knowledge based authentication attacks (2011)

Knowledge Based authentication is still the most widely used and accepted technique for securing resources from unauthorized access for its simplicity, ease of revocation and legacy deployment which divides to textual and graphical password. Over the last decade several attacks records for stealing user’s identity and confidential information using a single or combination of attacks. In this paper the attacks pattern of textual and graphical password describes according to CAPEC standard, following describing their effects on both conventional and image password. More over some categories lacks from detail research which highlighted and will select as future work.
Structural Evaluation of Silicon‐on‐Insulator Fabricated by a Direct Wafer Bonding and Numerically Controlled Polishing Technique (1991)

The structural perfection of silicon‐on‐insulator wafers prepared by direct wafer bonding and a numerically controlled polishing technique have been analyzed by means of x‐ray topography and angle polishing/etching. Defects (mainly bubbles), excess stress at bonding boundaries, and polishing damage were all evaluated. The measurements revealed that no significant damage remained in the final 3 μm thick top Si layer, although the presence of random interfacial strain and accompanying stress of the order 106 dyne/cm2 remains, due to a nonplanar bonding interface.
Convolutional codes for the high density (1-D)(1+D)/sup n/ magnetic recording channel (2002)

We extend the technique due to Wolf and Ungerboeck (1986) of using convolutional codes (CC) along with preceding to improve the reliability of digital transmission/recording over the noisy (1-D) partial response (PR) channel to the more general class of channels described by the polynomials P/sub n/(D)=(1-D)(1+D)/sup n/. This class of polynomials models the high density magnetic recording channel (HDMRC), as pointed out by Thapar and Patel (1987). As a result, the same asymptotic coding gain (due to the CC) that is achieved on the noisy (1-D) channel can be realized on the HDMRC.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
DYRK1A interacts with the REST/NRSF-SWI/SNF chromatin remodelling complex to deregulate gene clusters involved in the neuronal phenotypic traits of Down syndrome (2009)

The molecular mechanisms that lead to the cognitive defects characteristic of Down syndrome (DS), the most frequent cause of mental retardation, have remained elusive. Here we use a transgenic DS mouse model (152F7 line) to show that DYRK1A gene dosage imbalance deregulates chromosomal clusters of genes located near neuron-restrictive silencer factor (REST/NRSF) binding sites. We found that Dyrk1a binds the SWI/SNF complex known to interact with REST/NRSF. The mutation of a REST/NRSF binding site in the promoter of the REST/NRSF target gene L1cam modifies the transcriptional effect of Dyrk1a-dosage imbalance on L1cam. Dyrk1a dosage imbalance perturbs Rest/Nrsf levels with decreased Rest/Nrsf expression in embryonic neurons and increased expression in adult neurons. Using transcriptome analysis of embryonic brain subregions of transgenic 152F7 mouse line, we identified a coordinated deregulation of multiple genes that are responsible for dendritic growth impairment present in DS. Similarly, Dyrk1a overexpression in primary mouse cortical neurons induced severe reduction of the dendritic growth and dendritic complexity. We propose that DYRK1A overexpression-related neuronal gene deregulation via disturbance of REST/NRSF levels, and the REST/NRSF-SWI/SNF chromatin remodelling complex, significantly contributes to the neural phenotypic changes that characterize DS.
The Interaction of a Cationic Detergent with Bovine Serum Albumin and Other Proteins (1974)

The binding of tetradecyltrimethylammonium chloride to bovine serum albumin and several other globular proteins was measured, and the resulting conformational changes were studied by optical and hydrodynamic techniques. Native serum albumin was found to have four discrete binding sites for the detergent, to which binding occurs without conformational change, and with a much lower binding constant than for anionic detergents with alkyl chains of similar length. At higher detergent concentrations the cationic detergent resembles sodium dodecyl sulfate, binding cooperatively to serum albumin and to all other proteins studied, with accompanying gross denaturation to form extended rod-like complexes. However, this cooperative process occurs for the cationic detergent at a 10-fold higher concentration than is required for sodium dodecyl sulfate, with the result that completion of the transition was prevented (under the conditions used) by the onset of micelle formation. A possible explanation is offered for this difference, which probably applies to all cationic detergents. The results suggest that cationic detergents are not suitable as substitutes for sodium dodecyl sulfate in procedures in which the denaturing action of the detergent is an essential feature, as, for example, in the determination of molecular weight by gel chromatography or gel electrophoresis.
Increasing the length of single-wall carbon nanotubes in a magnetically enhanced arc discharge (2008)

It is demonstrated that a magnetic field has a profound effect on the length of a single-wall carbon nanotube (SWCNT) synthesized in the arc discharge. The average length of SWCNT increases by a factor of 2 in discharge with magnetic field as compared with the discharge without magnetic field, and the yield of long nanotubes with lengths above 5μm also increases. A model of SWCNT growth on metal catalyst in arc plasma was developed. Monte-Carlo simulations confirm that the increase of the plasma density in the magnetic field leads to an increase in the nanotube growth rate and thus leads to longer nanotubes.
Big data from the built environment (2011)

As sensor networks in buildings continue to grow in number and heterogeneity, occupants can become empowered to better control their environment for comfort maximization and energy minimization. Since buildings are the primary consumers of energy and are the dominant cause of greenhouse gases, apps that help occupants to understand and control their interactions with a building could be extremely beneficial to society. However, the massive raw data sets that could be collected must be aggregated and visualized to be usable which presents significant data handling, information visualization, and interaction challenges. In the context of Project Dasher, a prototype building site for exploring these issues, we discuss lessons learned and challenges ahead to develop ubiquitous computing support for sustainability.
Unit commitment and hydrothermal generation scheduling by multi‐pass dynamic programming (1993)

Abstract This paper applies a very efficient new technique, multi‐pass dynamic programming (MPDP) combined with successive approximations, to solve the weekly thermal unit commitment and hydrothermal generation scheduling problem. Conceptually, dynamic programming is suited for solving this problem, but the long computing time and the large storage memory required become unacceptable for large power systems and long scheduling periods. The MPDP technique can overcome these difficulties. Furthermore, the unit start‐up cost and pumped storage plants are considered in the hydrothermal coordination instead of only the production cost as in the previous application. The algorithm is tested on Taipower system with forty thermal units, seven conventional hydro units and one pumped storage plant. The results show that this method is suitable for practical systems.
Fertilization and early embryology: Human blastocyst grading: an indicator of developmental potential? (1993)

We have observed marked variation in the in-vitro development of individual human embryos to the blastocyst stage which was poorly associated with the grade of the embryo on the day of transfer (day 2). Therefore we also graded embryos at the blastocyst stage to determine if their development potential can be better predicted at this stage. A total of 41 blastocysts were categorized into three grades depending on their morphology. Various parameters such as hatching, adherence, growth and amount of human chorionic gonadotrophin (HCG) secreted were documented. The number of nuclei in another 34 blastocysts belonging to the three grades were measured. Also morula stage embryos with large vacuoles but no morphological differentiation were included in a separate group called 'vacuolated morulae'. Overall, there was no significant difference between grade 1 and 2 blastocysts as assessed by their development to day 14, cumulative HCG secretion and nuclei counts. Grade 3 blastocysts reflected 'poor' morphology, secreted significantly lower levels of HCG and had significantly fewer nuclei than the other two grades. Vacuolated morulae did not resemble blastocysts in their morphological development, secreted no HCG and had significantly fewer nuclei than grade 1 and 2 blastocysts. This study illustrates the need for selecting blastocysts for transfer to the uterus or for cryopreservation to allow a better assessment of the success of these techniques. In addition, the data will be useful for evaluating the effects of techniques such as co-culture with feeder cells on the development of embryos to the blastocyst stage and beyond.
Multimodal Data Fusion Based on Mutual Information (2011)

Multimodal visualization aims at fusing different data sets so that the resulting combination provides more information and understanding to the user. To achieve this aim, we propose a new information-theoretic approach that automatically selects the most informative voxels from two volume data sets. Our fusion criteria are based on the information channel created between the two input data sets that permit us to quantify the information associated with each intensity value. This specific information is obtained from three different ways of decomposing the mutual information of the channel. In addition, an assessment criterion based on the information content of the fused data set can be used to analyze and modify the initial selection of the voxels by weighting the contribution of each data set to the final result. The proposed approach has been integrated in a general framework that allows for the exploration of volumetric data models and the interactive change of some parameters of the fused data set. The proposed approach has been evaluated on different medical data sets with very promising results.
Attenuation and ratio—National standards (1986)

In national standards laboratories, the popular attenuation measurement techniques are: RF, IF, vector IF, and AF substitution; power ratio, voltage ratio, time-interval ratio, and six-port methods; and a procedure that employs a Josephson junction in a superconducting ring. These nine techniques are briefly described, the dynamic ranges and accuracies achieved with them are reported, and their relative merits are discussed. The later sections are devoted to: attenuation measurement techniques used in industry and elsewhere, voltage doubling circuits, attenuation traveling standards, errors and uncertainties associated with attenuation measurements, and international attenuation comparisons. An analysis of the results obtained in four recent international comparisons is included.