gebhart/patrepeval huggingface dataset:
Studies of the solvolysis of 2-adamantyl pentafluorobenzenesulfonate. A YPFBS scale (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudies of the solvolysis of 2-adamantyl pentafluorobenzenesulfonate. A YPFBS scaleDavid C. Hawkinson and Dennis N. KevillCite this: J. Org. Chem. 1988, 53, 16, 3857–3860Publication Date (Print):August 1, 1988Publication History Published online1 May 2002Published inissue 1 August 1988https://pubs.acs.org/doi/10.1021/jo00251a039https://doi.org/10.1021/jo00251a039research-articleACS PublicationsRequest reuse permissionsArticle Views69Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A study in transfer learning: leveraging data from multiple hospitals to enhance hospital-specific predictions (2014)

We show how external data from other hospitals can be successfully and efficiently incorporated into hospital-specific models.
Inhibition of Thr-55 phosphorylation restores p53 nuclear localization and sensitizes cancer cells to DNA damage (2008)

The p53 tumor suppressor induces cell growth arrest and apoptosis in response to DNA damage. Because these functions are achieved largely by the transcriptional properties of p53, nuclear localization of the protein is essential. Indeed, the tumors with aberrant cytoplasmic localization of wild-type p53 often exhibit an impaired response to DNA damage. In this study, we report that Thr-55 phosphorylation induces the association of p53 with the nuclear export factor CRM1, leading to p53 nuclear export. We further show that MDM2 also promotes the CRM1-p53 association and Thr-55 phosphorylation is required for this process. Interestingly, inhibition of Thr-55 phosphorylation by a dietary flavonoid, apigenin, specifically blocks the CRM1-p53 association, restores p53 nuclear localization, and sensitizes tumor cells with cytoplasm localized wild-type p53 to DNA damage. These data provide insights into the regulation of p53 nuclear localization by post-translational modification and suggest an avenue for targeted therapy for cancers caused by aberrant cytoplasm localization of wild-type p53.
Electrochemistry of zinc, cadmium, and mercury ions in fused AlCl<sub>3</sub>–NaCl–KCl eutectic (1968)

The electrochemistry of the ions of zinc, cadmium, and mercury in the AlCl 3 –NaCl–KCl eutectic at 150 °C was investigated by e.m.f., voltammetric, and chronopotentiometric techniques. Oxidation states of +2 were observed for these three elements and oxidation states of +1 were observed for cadmium and mercury. Values of equilibrium constants for the reactions [Formula: see text] and [Formula: see text] were calculated to be 26 and 36 000 respectively. A standard potential scale for the Zn(II)/Zn, Hg(II)/Hg(I), Hg(I)/Hg(0), Ag(I)/Ag(0), and Al(III)/Al(0) couples was established in the solvent system AlCl 3 –NaCl–KCl.
Profound Reduction in T-helper (Th) 1 lymphocytes in Peripheral Blood from Patients with Concurrent Type 1 Diabetes and Graves' Disease (2006)

Type 1 diabetes likely is mediated by T-helper (Th) 1 lymphocytes, while Graves' disease may involve Th2 predominance. We investigated the balance between Th1 and Th2 cells and between Th1- and Th2-associated chemokine receptor expression on peripheral lymphocytes in subjects including patients with coexisting type 1 diabetes and Graves' disease. Peripheral blood mononuclear cells of all subjects were examined by flow cytometry for intracellular cytokines (IFN-γ for Th1; IL-4 for Th2) and expression of the chemokine receptors CXCR3 (Th1-associated) and CCR4 (Th2-associated). Plasma concentrations of interferon-inducible protein (IP)-10, a CXCR3 ligand, and thymus and activation-regulated chemokine (TARC), a CCR4 ligand, were measured by enzyme-linked immunosorbent assays. IFN-γ producing-T lymphocytes were significantly fewer in patients with coexisting type 1 diabetes and Graves' disease (12.4 ± 6.8%, n = 6) than in healthy control subjects (19.9 ± 4.1%, n = 6; P<0.01) or patients with type 2 diabetes (19.1 ± 4.5%, n = 5; P<0.05). We found no significant difference in IFN-γ-producing T lymphocytes between healthy controls and patients with only type 1 diabetes (n = 8) or Graves' disease (n = 5). Plasma IP-10 concentrations were significantly higher in patients with coexisting type 1 diabetes and Graves' disease than in control subjects (106.3 ± 30.48 vs. 66.7 ± 25.3 pg/ml, P = 0.0343). Considering only patients with type 1 diabetes alone, duration of diabetes correlated positively with IFN-γ-producing T lymphocytes (r = 0.773, P = 0.0242) and the ratio of CXCR3 to CCR4 receptor expression (r = 0.947, P = 0.0004). In conclusion, Th1-associated T lymphocytes were fewer in peripheral blood from patients having both type 1 diabetes and Graves' disease than in those with either disease alone. Numbers of peripheral Th1 lymphocytes increased with increasing time from onset of type 1 diabetes in patients with type 1 diabetes alone.
Computational intelligence approach for uncertainty quantification using evidence theory (2013)

As an alternative or complementary approach to the classical probability theory,the ability of the evidence theory in uncertainty quantification(UQ) analyses is subject of intense research in recent years.Two state-of-the-art numerical methods,the vertex method and the sampling method,are commonly used to calculate the resulting uncertainty based on the evidence theory.The vertex method is very effective for the monotonous system,but not for the non-monotonous one due to its high computational errors.The sampling method is applicable for both systems.But it always requires a high computational cost in UQ analyses,which makes it inefficient in most complex engineering systems.In this work,a computational intelligence approach is developed to reduce the computational cost and improve the practical utility of the evidence theory in UQ analyses.The method is demonstrated on two challenging problems proposed by Sandia National Laboratory.Simulation results show that the computational efficiency of the proposed method outperforms both the vertex method and the sampling method without decreasing the degree of accuracy.Especially,when the numbers of uncertain parameters and focal elements are large,and the system model is non-monotonic,the computational cost is five times less than that of the sampling method.
Pharmacological Targeting of the Transcription Factor Nrf2 at the Basal Ganglia Provides Disease Modifying Therapy for Experimental Parkinsonism (2011)

Current therapies for motor symptoms of Parkinson's disease (PD) are based on dopamine replacement. However, the disease progression remains unaffected, because of continuous dopaminergic neuron loss. Since oxidative stress is actively involved in neuronal death in PD, pharmacological targeting of the antioxidant machinery may have therapeutic value. Here, we analyzed the relevance of the antioxidant phase II response mediated by the transcription factor NF-E2-related factor 2 (Nrf2) on brain protection against the parkinsonian toxin methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Intraperitoneal administration of the potent Nrf2 activator sulforaphane (SFN) increased Nrf2 protein levels in the basal ganglia and led to upregulation of phase II antioxidant enzymes heme oxygenase-1 (HO-1) and NAD(P)H quinone oxidoreductase (NQO1). In wild-type mice, but not in Nrf2-knockout mice, SFN protected against MPTP-induced death of nigral dopaminergic neurons. The neuroprotective effects were accompanied by a decrease in astrogliosis, microgliosis, and release of pro-inflammatory cytokines. These results provide strong pharmacokinetic and biochemical evidence for activation of Nrf2 and phase II genes in the brain and also offer a neuroprotective strategy that may have clinical relevance for PD therapy.
Optical properties of helically twisted solid-core photonic crystal fibre (2014)

Recent results on excitation of orbital angular momentum modes and optical activity in continuously twisted solid-core photonic crystal fibre, including its fabrication, theoretical analysis and numerical modelling, will be presented.
Toll‐like receptor (TLR)‐2 and TLR‐4 regulate inflammation, gliosis, and myelin sparing after spinal cord injury (2007)

Activation of macrophages via toll-like receptors (TLRs) is important for inflammation and host defense against pathogens. Recent data suggest that non-pathogenic molecules released by trauma also can trigger inflammation via TLR2 and TLR4. Here, we tested whether TLRs are regulated after sterile spinal cord injury (SCI) and examined their effects on functional and anatomical recovery. We show that mRNA for TLR1, 2, 4, 5, and 7 are increased after SCI as are molecules associated with TLR signaling (e.g. MyD88, NFkappaB). The significance of in vivo TLR2 and TLR4 signaling was evident in SCI TLR4 mutant (C3H/HeJ) and TLR2 knockout (TLR2-/-) mice. In C3H/HeJ mice, sustained locomotor deficits were observed relative to SCI wild-type control mice and were associated with increased demyelination, astrogliosis, and macrophage activation. These changes were preceded by reduced intraspinal expression of interleukin-1beta mRNA. In TLR2-/- mice, locomotor recovery also was impaired relative to SCI wild-type controls and novel patterns of myelin pathology existed within ventromedial white matter--an area important for overground locomotion. Together, these data suggest that in the absence of pathogens, TLR2 and TLR4 are important for coordinating post-injury sequelae and perhaps in regulating inflammation and gliosis after SCI.
A study on the framework and indicators for open innovation performance via AHP approach (2011)

Innovation is the key for an organization to achieve sustainable development. Open innovation which emphasizes the integration of internal and external resources in an organization has brought about a new perspective in technological developments. In order to promote and ensure the performance of the open innovation, an assessment framework and the evaluation indicators are required. This study extracted dimensions from literatures and developed performance indicators by compiling opinions from both academic researchers and business experts. The study then flowed into an Analytic Hierarchy Process for data analysis. The systematic level included “Technology execution,” “Technology exploitation” and “Technology exploration” and among all the sub-dimensions for open innovation performance, “Employee involvement” was the most significant. This study identified three significant indicators that are suggested by academic and business experts: “The percentage of successful cross-departmental staff participation in new product development”, “The degree of incentive/reward system implementation for innovation”, and “The degree of innovation sharing among employees”.
Sub‐optimal morning temperature induces photoinhibition in dense outdoor cultures of the alga <i>Monodus subterraneus</i> (Eustigmatophyta) (2001)

Abstract Diel changes in photosynthetic oxygen evolution and several photochemical parameters measured by chlorophyll fluorescence quenching and induction were measured in outdoor dense cultures of the alga Monodus subterraneus (Eustigmatophyta) . Cultures were maintained under two temperature regimes. In one, a rise in temperature was initiated in the morning by the increase in solar radiation up to the optimal temperature of 28 °C; in the other, a heating device was used to increase the rate of warming up in early morning. Although the two cultures were maintained at the same temperature and light intensity for most of the day, cultures exposed for only a short time to suboptimal morning temperature showed a larger decrease in almost all the photosynthetic parameters. By comparing the diel changes in maximal photochemistry efficiency of photosystem II, the electron transport rate and the photochemical and non‐photochemical chlorophyll fluorescence quenching of the cultures, we concluded that even a relatively short exposure to suboptimal morning temperatures induced photoinhibitory damage. The higher photochemical activity of the heated culture was also reflected in a significant increase in productivity, which was 60% higher in the morning heated cultures than in the non‐heated cultures.
Hepcidin and Cytokines in Anaemia (2004)

Hepcidin is a cytokine-induced antibacterial protein which is produced in the liver, circulates in the blood, and is excreted in the urine. It is a major regulator of iron balance in the intestinal mucosa, and appears to have a significant role in the pathogenesis of haemochromatosis and related disorders. Hepcidin appears to be a major contributor to the hypoferraemia associated with inflammation. Serum ferritin concentration is strongly correlated with hepcidin protein levels in either urine or serum, and certain patients with hepatic adenomas exhibit a microcytic, hypoferraemic hepcidin-dependent anaemia. For these reasons, it has been proposed that hepcidin is a primary factor in the pathogenesis of the anaemia of chronic disease (ACD), a cytokine-mediated anaemia commonly encountered in clinical practice and characterized by hypoferraemia with adequate reticuloendothelial iron stores. However, the pathogenetic basis of ACD is not entirely due to changes in iron metabolism, but also involves abnormalities in red cell survival and the erythropoietic response to anaemia. In this review, the evidence for involvement of hepcidin as a major mediator of ACD is evaluated. Hepcidin appears to be a major factor in the systemic iron abnormalities seen in ACD; whether it contributes to the other aspects of the pathogenesis of the syndrome requires further investigation.
Alphavirus-induced apoptosis in mouse brains correlates with neurovirulence (1996)

Sindbis virus induces apoptotic cell death in cultured cell lines, raising the possibility that apoptosis of infected neurons and other target cells in vivo may contribute to the resulting disease and mortality. To investigate the role of apoptosis in Sindbis virus pathogenesis, infected mouse brains were assayed by the in situ terminal deoxynucleotidyltransferase-mediated dUTP nick end-labeling technique and for DNA ladder formation. Infection with recombinant Sindbis virus strain 633 resulted in widespread apoptosis in newborn mouse brains and spinal cords, but few apoptotic cells were observed following infection of 2-week-old animals. This finding correlates with the age-dependent mortality observed in mice. The more neurovirulent virus TE, which differs from 633 by a single amino acid in the E2 glycoprotein, induced significant apoptosis in brains and spinal cords of 2-week-old animals, consistent with its ability to cause fatal disease in older animals. Double-labeling experiments demonstrated that the apoptotic cells were also infected with Sindbis virus. Thus, Sindbis virus-induced apoptosis appears to be a result of virus infection and is likely to reflect pathogenic mechanisms for other viruses.
Efficient Locking for Shared Memory Database Systems (1994)

Significant performance advantages can be realized by implementing a database system on a shared memory multiprocessor. An efficient implementation of a lock manager is a prerequisite for efficient transaction processing in multiprocessor database systems. To this end, we advocate adopting an autonomous locking strategy. In autonomous locking, transactions acquire and release locks via operations on shared memory, in contrast to conventional locking where communication with a lock manager is involved. We demonstrate the superior performance and scalability of autonomous locking through benchmarks of a prototype lock manager implemented on a large scale shared memory multiprocessor. For instance, when contention is high (i.e., for hot lock operations), the performance of autonomous locking is nearly an order of magnitude better than conventional locking. The paper also addresses issues related to recovery (assuming independent node failures). 1 Partially supported by the National Scie...
Synthesis of isosteric phosphonate analogs of some biologically important phosphodiesters (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of isosteric phosphonate analogs of some biologically important phosphodiestersGordon Henry Jones, Hans P. Albrecht, N. P. Damodaran, and John G. MoffattCite this: J. Am. Chem. Soc. 1970, 92, 18, 5510–5511Publication Date (Print):September 1, 1970Publication History Published online1 May 2002Published inissue 1 September 1970https://doi.org/10.1021/ja00721a034Request reuse permissionsArticle Views243Altmetric-Citations43LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (238 KB) Get e-Alertsclose Get e-Alerts
Barker sequences and flat polynomials (2008)

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La legitimación en el recurso de amparo: reglas generales y supuestos especiales (2012)

La legitimacion, tanto activa como pasiva, en el recurso de amparo, esta regulada de forma muy somera en la LOTC, por lo que resulta necesario completar las previsiones constitucionales y legales con supuestos resueltos por el propio Tribunal Constitucional, especialmente de impugnacion de la legitimacion activa.
Lifelong learning of human actions with deep neural network self-organization (2017)

Lifelong learning is fundamental in autonomous robotics for the acquisition and fine-tuning of knowledge through experience. However, conventional deep neural models for action recognition from videos do not account for lifelong learning but rather learn a batch of training data with a predefined number of action classes and samples. Thus, there is the need to develop learning systems with the ability to incrementally process available perceptual cues and to adapt their responses over time. We propose a self-organizing neural architecture for incrementally learning to classify human actions from video sequences. The architecture comprises growing self-organizing networks equipped with recurrent neurons for processing time-varying patterns. We use a set of hierarchically arranged recurrent networks for the unsupervised learning of action representations with increasingly large spatiotemporal receptive fields. Lifelong learning is achieved in terms of prediction-driven neural dynamics in which the growth and the adaptation of the recurrent networks are driven by their capability to reconstruct temporally ordered input sequences. Experimental results on a classification task using two action benchmark datasets show that our model is competitive with state-of-the-art methods for batch learning also when a significant number of sample labels are missing or corrupted during training sessions. Additional experiments show the ability of our model to adapt to non-stationary input avoiding catastrophic interference.
Design and performance of an x-ray lithography beam line at a storage ring (1983)

A beam line for x-ray lithography using synchrotron radiation (SR) has been built at the VUV storage ring of the National Synchrotron Light Source and is now in operation. The high intensity and good collimation of SR overcome the problems of low throughput and resolution-limiting penumbra associated with using conventional x-ray sources. The design of a beam line for SR has to deal with two problems. First, the beam line must meet the ultrahigh vacuum standards of the storage ring, and second, the emitted radiation is horizontally uniform but very nonuniform vertically. The beam line optics consist of an oscillating cylindrical mirror that scans the reflected light vertically over the exposure area and collimates the incident radiation horizontally, thus increasing the intensity by a factor of 3. We will describe the vacuum system, the beryllium window that separates the exposure chamber from the beam line, and the vacuum protection of the ring. We will show the measured uniformity of illumination. The energy density incident onto the resist as well as the energy absorbed in the resist have been determined and will be compared with the calculated power distribution. First exposures show that features down to 0.25 μm can be copied into PMMA with an aspect ratio of 10 to 1 using a 40 μm mask-to-wafer separation.
Oxygen Radical Absorbance Capacity (ORAC) and Phenolic and Anthocyanin Concentrations in Fruit and Leaf Tissues of Highbush Blueberry (2001)

Antioxidant capacity, as measured by oxygen radical absorbance capacity (ORAC), and total phenolic and total anthocyanin contents were evaluated in fruit tissues of 87 highbush blueberry (Vacciniumcorymbosum L.) and species-introgressed highbush blueberry cultivars. ORAC and phenolic levels were evaluated in leaf tissues of the same materials. Average values for ORAC, phenolics, and anthocyanins in fruit were 15.9 ORAC units, 1.79 mg/g (gallic acid equivalents), and 0.95 mg/g (cyanidin-3-glucoside equivalents), respectively. Cv. Rubel had the highest ORAC per gram of fresh weight values, at 31.1 units, and cv. Elliott had the highest values on the basis of ORAC per square centimeter of surface area. In leaf tissue, values for both ORAC and phenolics were significantly higher than in fruit tissue, with mean values of 490 ORAC units and 44.80 mg/g (gallic acid equivalents), respectively. Leaf ORAC had a low, but significant, correlation with fruit phenolics and anthocyanins, but not with fruit ORAC. An analysis of ORAC values versus calculated midparent values in 11 plants from the 87-cultivar group in which all parents were tested suggested that, across cultivars, ORAC inheritance is additive. An investigation of ORAC values in a family of 44 cv. Rubel x Duke seedlings showed negative epistasis for ORAC values, suggesting Rubel may have gene combinations contributing to ORAC that are broken up during hybridization.