gebhart/patrepeval huggingface dataset:
Integrated quantum well self-electro-optic effect device: 2×2 array of optically bistable switches (1986)

We demonstrate 2×2 arrays of optically bistable devices with very uniform optical characteristics. They are fabricated from an integrated self-electro-optic effect device structure consisting of a quantum well p-i-n diode grown in series with a load photodiode. Operating power can be optically controlled with a separate beam between ∼40 pW and &gt;470 μW with associated switching times of ∼10 s and &lt;2 μs.
Establishment and characterization of a novel acute promyelocytic leukemia cell line (UF-1) with retinoic acid-resistant features (1996)

All-trans retinoic acid (RA) induces complete remission in a high proportion of patients with acute promyelocytic leukemia (APL). Nevertheless, most of these patients develop RA resistance and relapse. The mechanisms of RA resistance by APL cells are still unclear. To understand the characteristics of human leukemia, human leukemic cell lines are useful tools for study. APL cells have a strikingly low proliferation potential in vitro; thus, only one APL cell line has been established. We developed a novel APL cell line (UF-1) from a patient clinically resistant to all-trans RA. Cell surface markers in the UF-1 cells were positive for CD7, CD13, CD33, and CD38. Cytogenetic analyses revealed additional abnormalities, 46XX, add(1)(q44), add(6)(q12), add(7)(q36), t(15;17) (q21;q21). Molecular analyses showed a PML/RAR alpha fusion transcript. Sequence analysis of the RAR alpha gene in RA- resistant HL-60 cells disclosed a point mutation in codon 411 (C to T substitution), whereas UF-1 cells showed the normal sequence. All-trans RA did not change morphological features of the cell, NBT reduction activity, or their expression of CD11b antigens as determined by FACS analysis except at 10(-6) mol/L. RA also did not alter the growth curve of the cells as determined by the MTT assay. These findings suggest that the UF-1 cell is the first permanent cell line with spontaneous RA- resistant APL cells. This RA-resistant APL cell line may be a useful model for molecular studies on the block of leukemic cell differentiation and as a means to investigate the mechanisms of RA resistance.
Automatic I/O prefetching for out-of-core applications (1997)

Automatic I/O Prefetching for Out-of-Core Applications Angela K. Demke Master of Science Graduate Department of Computer Science University of Toronto 1997 In this thesis, we propose and evaluate a fully-automatic technique to manage the I/O requirements of out-of-core scientific applications. In our scheme, the compiler determines information on future access patterns and inserts prefetch and release operations to initiate I/O before the data is needed and to free pages that are no longer accessed. No modifications to the original application source code are needed to support our compiler analysis. The operating system provides support for the basic prefetch and release operations and interacts with a run-time layer to accelerate performance by minimizing prefetch overhead. We have implemented our scheme using the SUIF compiler and the Hurricane operating system. Our experimental results demonstrate that our fully-automatic scheme effectively hides the I/O latency in out-of-cor...
Semi-supervised Learning using Denoising Autoencoders for Brain Lesion Detection and Segmentation (2016)

The work presented explores the use of denoising autoencoders (DAE) for brain lesion detection, segmentation and false positive reduction. Stacked denoising autoencoders (SDAE) were pre-trained using a large number of unlabeled patient volumes and fine tuned with patches drawn from a limited number of patients (n=20, 40, 65). The results show negligible loss in performance even when SDAE was fine tuned using 20 patients. Low grade glioma (LGG) segmentation was achieved using a transfer learning approach wherein a network pre-trained with High Grade Glioma (HGG) data was fine tuned using LGG image patches. The weakly supervised SDAE (for HGG) and transfer learning based LGG network were also shown to generalize well and provide good segmentation on unseen BraTS 2013 & BraTS 2015 test data. An unique contribution includes a single layer DAE, referred to as novelty detector(ND). ND was trained to accurately reconstruct non-lesion patches using a mean squared error loss function. The reconstruction error maps of test data were used to identify regions containing lesions. The error maps were shown to assign unique error distributions to various constituents of the glioma, enabling localization. The ND learns the non-lesion brain accurately as it was also shown to provide good segmentation performance on ischemic brain lesions in images from a different database.
New convenient reagent for peptide syntheses (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew convenient reagent for peptide synthesesBernard Belleau and G. MalekCite this: J. Am. Chem. Soc. 1968, 90, 6, 1651–1652Publication Date (Print):March 1, 1968Publication History Published online1 May 2002Published inissue 1 March 1968https://doi.org/10.1021/ja01008a045RIGHTS & PERMISSIONSArticle Views2278Altmetric-Citations353LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (223 KB) Get e-Alertsclose Get e-Alerts
SWI-Prolog (2011)

Abstract SWI-Prolog is neither a commercial Prolog system nor a purely academic enterprise, but increasingly a community project. The core system has been shaped to its current form while being used as a tool for building research prototypes, primarily for knowledge-intensive and interactive systems. Community contributions have added several interfaces and the constraint (CLP) libraries. Commercial involvement has created the initial garbage collector, added several interfaces and two development tools: PlDoc (a literate programming documentation system) and PlUnit (a unit testing environment). In this article, we present SWI-Prolog as an integrating tool, supporting a wide range of ideas developed in the Prolog community and acting as glue between foreign resources. This article itself is the glue between technical articles on SWI-Prolog, providing context and experience in applying them over a longer period.
Co-expression of Achaete-Scute Homologue-1 and Calcitonin Gene-Related Peptide during NNK-Induced Pulmonary Neuroendocrine Hyperplasia and Carcinogenesis in Hamsters (2016)

Achaete-scute homologue-1 or ASCL1 (MASH1, hASH1) plays roles in neural development and pulmonary neuroendocrine (NE) differentiation, and it is expressed in certain lung cancers. This study was aimed to assess whether and/or how ASCL1 plays a role in 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced pulmonary NE hyperplasia and carcinogenesis in hamsters. Hamsters were injected 3 times weekly with either NNK or solvent alone (control) for treatment periods of 6 and 24 weeks, both without and with 6-week recovery. Immunohistochemical analysis was carried out to examine the expressions of ASCL1, CGRP (calcitonin gene-related peptide), secretoglobin SCGB1A1 (club [Clara] cell specific 10 kD protein, CC10, CCSP), synaptophysin (SYP), and PCNA (proliferating cell nuclear antigen). The number of ASCL1-expressing NE foci per airway increased from 0.8 in controls to 1.6 and 2.0 during NNK exposure for 6 and 24 weeks, respectively, and the number of cells per foci doubled after NNK exposure. Most ASCL1-expressing cells in NEBs (neuroepithelial bodies) were also CGRP immunoreactive; NNK enhanced this co-expression with CGRP, a NE marker with known proliferation-promoting properties. NNK also increased PCNA expression within NE foci. NNK-induced tumors showed no immunoreactivity for NE markers. This study confirms ASCL1 as an excellent marker for pulmonary NE cells and demonstrates CGRP co-expression in ASCL1-positive NEB cells participating in NNK-induced NE hyperplasia.
Unified Model of Relative Rotation, Non-linear Dynamics System and Chaos Movement Analysis (2010)

The two end surface revolution axis relative rotation system and a kind of two qualities relative rotation system unified non-linear dynamics model are established, in the non-linear resiliency and the generalized damping force. And the chaos movement performance of unification system is studied, under weak cyclical strength condition as well. Key words : Relative rotation; Non-linear dynamic system; Chaos movement
Position-Dependent Transcriptional Regulation of the Murine Dihydrofolate Reductase Promoter by the E2F Transactivation Domain (1997)

Activity of the dihydrofolate reductase (dhfr) promoter increases at the G1-S-phase boundary of the cell cycle. Mutations that abolish protein binding to an E2F element in the dhfr promoter also abolish the G1-S-phase increase in dhfr transcription, indicating that transcriptional regulation is mediated by the E2F family of proteins. To investigate the mechanism by which E2F regulates dhfr transcription, we moved the E2F element upstream and downstream of its natural position in the promoter. We found that the E2F element confers growth regulation to the dhfr promoter only when it is proximal to the transcription start site. Using a heterologous E2F element, we showed that position-dependent regulation is a property that is promoter specific, not E2F element specific. We demonstrated that E2F-mediated growth regulation of dhfr transcription requires activation of the dhfr promoter in S phase and that the C-terminal activation domains of E2F1, E2F4, and E2F5, when fused to the Gal4 DNA binding domain, are sufficient to specify position-dependent activation. To further investigate the role of activation in dhfr regulation, we tested other transactivation domains for their ability to activate the dhfr promoter. We found that the N-terminal transactivation domain of VP16 cannot activate the dhfr promoter. We propose that, unlike other E2F-regulated promoters, robust transcription from the dhfr promoter requires an E2F transactivation domain close to the transcription start site.
[Combination of microfracture and periosteal transplantation techniques for the treatment of full-thickness cartilage defects]. (2006)

Due to markedly improved quality of repair, the combination of the microfracture and periosteal flap techniques seems to be more effective than either of the techniques used alone in the treatment of cartilage defects.
Pharmacological and clinical aspects of some drugs used in peptic ulcer treatment. (1979)

A healing effect of carbenoxolone and colloidal bismuth on gastric and duodenal ulcer has been demonstrated in several studies. The use of carbenoxolone is limited by the high frequency of side effects. Information on the ability of these drugs to prevent ulcer recurrences is sparse. Further studies are needed to determine the ulcer-healing effect of deglycyrrhizinised liquorice. Sulpiride, a dopamine-blocking agent, seems to have interesting inhibitory effects on gastric secretion but its anti-ulcer activity is not yet clear.
The relation of axonal transport of mitochondria with microtubules and other axoplasmic organelles. (1977)

Axonal transport of mitochondria was studied in frog sciatic nerves incubated in agents selected for their known or alleged effect on microtubules or axonal flow. Quantitative data on mitochondria, microtubules, neurofilaments, endoplasmic reticulum, and cross-sectional area of the axon indicate that axonal transport of mitochondria is dependent on microtubules. When more than half of the microtubules are destroyed, the axonal transport of mitochondria is diminished in proportion to the destruction of microtubules. Axonal transport of mitochondria is not related to neurofilaments and endoplasmic reticulum. Changes in the cross-sectional area of axons, even upon reduction to half the normal size, do not noticeably affect mitochondrial transport. Cyanide which blocks oxidative metabolism also blocks axonal transport of mitochondria, but analysis of fine structure indicates that cyanide is destructive to microtubules as well.
Inhibition of tumor promoter-induced transformation by retinoids that transrepress AP-1 without transactivating retinoic acid response element. (1996)

Both retinoic acid (RA) treatment and dominant-negative c-Jun mutant expression effectively inhibit phorbol ester-induced AP-1 activity and induced neoplastic transformation in mouse epidermal JB6 cells. However, both reagents also target non-AP-1 molecules in addition. Because liganded retinoic acid receptors interact with and transactivate RA response elements (RAREs) on DNA, as well as interact with Jun protein to block AP-1 activity, the question arises as to which of these two activities of retinoids is responsible for antitumor-promoting activity. To address this question we generated JB6 promotion-sensitive (P+) cell lines that are stably transfected with a construct containing the collagenase promoter bearing one AP-1-binding site that drives a luciferase reporter gene. The stable collagenase-luciferase-transfected cell lines showed 1.5-3.5-fold enhanced AP-1 activity when treated with 12-0-tetradecanoyl-phorbol-13-acetate (TPA). Up to 90% of TPA-induced AP-1 activity was blocked by retinoids SR11238, SR11302, or trans-RA, but not by retinoid SR11235. Of these retinoids, only RA and SR11235 were able to transactivate RARE-dependent gene expression. Transrepression of TPA-induced AP-1 and transactivation of RARE by RA, SR11238, and SR11302 were concentration dependent at 10(-10) to 10(-6) M retinoid. When tested for activity in inhibiting tumor promoter-induced transformation in JB6 P+ cells, the retinoids specific for AP-1 transrepression were inhibitory, whereas SR11235, which only activated RARE, showed little effect. We thus conclude that the AP-1-blocking activity of retinoids is likely to be responsible for the antitumor-promoting activity. This result, together with the observation that dominant-negative Jun blocks transformation, argues for a requirement of induced AP-1 in the tumor promoter-induced transformation process.
Profiling the Enzymatic Properties and Inhibition of Human Complement Factor B (2007)

Human complement factor B is the crucial catalytic component of the C3 convertase enzyme that activates the alternative pathway of complement-mediated immunity. Although a serine protease in its own right, factor B circulates in human serum as an inactive zymogen and there is a crystal structure only for the inactive state of factor B and various fragments. To provide greater insight to the catalytic function and properties of factor B, we have used short para-nitroanilide derivatives of 4- to 15-residue peptides as substrates to profile the catalytic properties of factor B. Among factors found to influence catalytic activity of factor B was an unusual dependence on pH. Non-physiological alkaline conditions strongly promoted substrate cleavage by factor B, consistent with a pH-accessible conformation of the enzyme that may be critical for catalytic function. Small N-terminal extensions to conventional hexapeptide para-nitroanilide substrates significantly increased catalytic activity of factor B, which was more selective for its cleavage site than trypsin. The new chromogenic assay enabled optimization of catalysis conditions, the profiling of different substrate sequences, and the development of the first reversible and competitive substrate-based inhibitor of factor B. The inhibitor was also shown to prevent in vitro formation of C3a from C3 by factor B, by synthetic and by natural C3 convertase of the alternative complement activation pathway, and to block formation of membrane attack complex. The availability of a reversible substrate-based inhibitor that could stabilize the active conformation of factor B, in conjunction with a pH-promoted higher processing activity, may offer a new avenue to obtain crystal structures of factor B and C3 convertase in an active conformation.
Cross-linking CD40 on B cells rapidly activates nuclear factor-<i>kappa</i> B. (1994)

The B cell-associated surface molecule CD40 functions to regulate B cell responses. Cross-linking CD40 on B cells can lead to homotypic cell adhesion, IL-6 production, and, in combination with cytokines, to Ig isotype switching. Tyrosine kinase activity is increased shortly after engagement of this receptor. Little is known about how the very early events induced by CD40 cross-linking link to cellular responses. In this study, we demonstrate that nuclear factor (NF)-kappa B and NF-kappa B-like transcription factors are activated after cross-linking CD40 on resting human tonsillar B cells and on B cell lines. The activation is rapid and is mediated through a tyrosine kinase-dependent pathway. The complexes detected in electrophoretic mobility shift assays contain p50, p65 (RelA), c-Rel, and most likely other components. By using transient transfection assays, we found that cross-linking CD40 supports NF-kappa B-dependent gene expression. Our results define the NF-kappa B system as an intermediate event in CD40 signaling and suggest that the CD40 pathway can influence the expression of B cell-associated genes with NF-kappa B consensus sites.
Binding of Manumycin A Inhibits IκB Kinase β Activity (2005)

IkappaB kinase (IKK) catalytic subunits play a key role in cytokinemediated nuclear factor (NF)-kappaB signaling, and a loss of NF-kappaB function appears to inhibit inflammation and oncogenesis. Manumycin A is a potent and selective farnesyltransferase inhibitor with antitumor activity. We found that manumycin A caused a rapid and potent inhibition of IKK activity induced by tumor necrosis factor alpha in a number of cell types. Most unexpectedly, other classes of farnesyltransferase inhibitors had no inhibitory effect. To identify the molecular mechanisms of manumycin A action, cultured human HepG2 hepatoma cells were transiently transfected with various IKKalpha and IKKbeta constructs, and a striking difference in manumycin A sensitivity was observed. Furthermore, cells expressing wild-type IKKbeta and IKKbeta mutated in the activation loop at Cys-179 exhibited covalent homotypic dimerization of IKKbeta in response to manumycin A, whereas substitution of Cys-662 and -716 conferred protection against dimer formation. Direct inhibition of IKK activity and formation of stable IKKbeta dimers were observed in the presence of manumycin A that could be blocked by dithiothreitol. IKK interaction with the adaptor protein IKKgamma/NEMO was disrupted in manumycin A-treated cells. Most importantly, administration of manumycin A to mice xenografted with murine B16F10 tumors caused potent IKK-suppressive effects. Thus, manumycin A with its epoxyquinoid moieties plays an important regulatory function in IKK signaling through pathways distinct from its role as a protein farnesylation inhibitor.
Concurrency by default (2009)

The rise of the multicore era is catapulting concurrency into mainstream programming. Current programming paradigms build in sequentiality, and as a result, concurrency support in those languages forces programmers into low-level reasoning about execution order. In this paper, we introduce a new programming paradigm in which concurrency is the default. Our Aeminium language uses access permissions to express logical dependencies in the code at a higher level of abstraction than sequential order. Therefore compiler/runtime-system can leverage that dependency information to allow concurrent execution. Because in Aeminium programmers specify dependencies rather than control flow, there is no need to engage in difficult, error-prone, and low-level reasoning about execution order or thread interleavings. Developers can instead focus on the design of the program, and benefit as the runtime automatically extracts the concurrency inherent in
Curing kinetics and thermomechanical behaviour of co‐anhydride cured aminoglycidyl epoxy resins (2003)

Abstract The curing behaviour and thermomechanical properties of a technical grade of N , N , N ′, N ′‐tetraglycidyl‐4,4′‐diaminodiphenylmethane (TGDDM, Araldite ® MY721), cured in the presence of an anhydride hardener mixture consisting of maleic anhydride (MA) and pyromellitic acid dianhydride (PMDA) was studied by calorimetric and dynamic mechanical analysis. The cure kinetics and the influence of varying stoichiometric anhydride‐to‐epoxy ratios were evaluated and the apparent activation energy was calculated according to Barrett's method. High extents of conversion from DSC studies of the MY721‐resin were reached after room temperature cure, without an added catalyst, for 24 h, followed by a post‐curing step of 1 h at 90 °C. The ultimate glass transition temperatures for the molar anhydride/epoxy ratio, r = 0.8, were close to the decomposition temperature, and indications were obtained that the network structure consists of two independent sub‐networks. It is suggested that two separate mechanisms contribute to the curing reaction at room temperature. First, the tertiary amine structure, intrinsic to aminoglycidyl resins, may act as an internal catalyst for the anhydride ring opening, and secondly, the unsaturated bond of MA participates in the curing reaction by nucleophilic attack, such as from tertiary amines or carboxylate or alkoxide anions. From a study of a range of different aminoglycidyl resins, this low‐temperature curing behaviour is found to be a general phenomenon. Copyright © 2003 Society of Chemical Industry
Connexin 43 mediated gap junctional communication enhances breast tumor cell diapedesis in culture (2005)

Collectively, our results suggest that heterocellular GJIC between breast tumor cells and endothelial cells may be an important regulatory step during metastasis.
A dictionary of antibiosis (1951)

A dictionary of antibiotics derived from living organisms, with the capabilities of modifying the vital function of a specific microorganism. Contains a compilation of substances tested for antibiotic activity; information on clinical results; and test organisms
EXPERIMENTAL ANALYSIS OF DESICCATION CRACK PROPAGATION IN CLAY LINERS<sup>1</sup> (1998)

ABSTRACT: A laboratory investigation on a scaled model of a landfill liner was conducted to provide data regarding the occurrence and extent of desiccation cracking of prototype liners. The crack intensity factor, CIF, was introduced as a descriptor of the extent of surficial cracking. CIF is defined as the ratio of the surface crack area A, to the total surface area of the clay liner, A t . A computer aided image analysis program was used to determine CII’ values from scanned photographs of the desiccation process. The variation of the CII’ was related to duration of drying and measured soil moisture suctions. The soil of this investigation experienced significant cracking, with crack widths approaching 10 mm in the first drying cycle and penetration through the entire 16 cm thickness. Crack propagation was limited to a very intense period of the desiccation process. Nearly 90 percent of the crack development occurred during a 19‐hour time period, although the total duration of the desiccation cycle was approximately 170 hours. The soil moisture suction changed by only 2 bars during the period of rapid crack growth, although it changed by more than 40 bars during the period of reduced growth.