gebhart/patrepeval huggingface dataset:
Multizone uniformity control of a chemical mechanical polishing process utilizing a pre- and postmeasurement strategy (2000)

Achieving good uniformity process control in chemical mechanical polishing (CMP) requires a representative uniformity metric and strong models relating this metric to process tunable inputs. Previous efforts in CMP uniformity control have yielded acceptable results utilizing a center-to-edge (CTE) first order nonuniformity metric. Closer analysis of post CMP process nonuniformity, however, reveals significant higher order nonuniformity components such as the center “dimple” and outer “doughnut” regions. These nonuniformity characteristics are due in part to upstream chemical vapor deposition (CVD) processing. Utilizing a multizone approach to uniformity modeling, a more accurate mathematical model of CMP uniformity has been identified. The model has been utilized to customize a thickness and uniformity multivariate run-to-run software control solution for the process. The controller is based on the generic cell controller structure, which is a proven enabler for run-to-run control for a number of processes including CMP, vapor phase epitaxy, and etch. The control algorithm is a zeroth order adjustable linear approximation two-stage algorithm with exponentially weighted moving average noise filtering. This algorithm, which supports first order linear and nonlinear models, has been demonstrated to be effective in CMP CTE and thickness multivariate control. The control solution has been enhanced to utilize both pre and post CMP process metrology along with process models to suggest process recipe modifications on a run-to-run basis. Results indicate improved control of CMP process nonuniformity qualities of interest. Further, the results quantify the significant benefit of utilizing premetrology (feedforward) information in addition to traditional postmetrology (feedback) in determining control recipe advice.
Development of an Effective Topical LiposomalFormulation for Localized Analgesia and Antiinflammatory Actions in the Complete Freund’sAdjuvant Rodent Model of Acute Inflammatory Pain (2014)

The study demonstrates that topically applied loperamide encapsulated within liposomal systems has improved therapeutic efficacy over conventional formulations for the local treatment of acute peripheral inflammatory pain conditions where the skin has remained intact. Once in the inflamed peripheral tissue, loperamide provides analgesic and anti-inflammatory effects in a similar manner to peripheral endogenous opioids. This preparation optimises the retention of drug at the site where action is required.
A technique for generating efficient simulators (2002)

A methodology is presented aimed at reducing the size of generated simulators and at increasing their simulation speed. This technique consists in abstracting the functionality of an architecture's control part into a data table and mapping it onto the main memory of a host computer. The Lille University simulator called LIDO was used as a testbed for experiments. Some decision making capabilities of the generator based on static analysis of characteristics of an architecture and empirically refined are presented. Results of comparative tests with a VHDL simulator are discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The Influence of Manganese and Glutamine Intake on Antioxidants and Neurotransmitter Amino Acids Levels in Rats’ Brain (2016)

Depending on the concentration, Mn can exert protective or toxic effect. Potential mechanism for manganese neurotoxicity is manganese-induced oxidative stress. Glutamine supplementation could reduce manganese-induced neurotoxicity and is able to influence the neurotransmission processes. The aim of this study was to investigate whether the long term administration of manganese (alone or in combination with glutamine) in dose and time dependent manner could affect the selected parameters of oxidative-antioxidative status (superoxide dismutase and glutathione peroxidase activities, concentrations of vitamin C and malonic dialdehyde) and concentrations of excitatory (Asp, Glu) and inhibitory amino acids (GABA, Gly) in the brain of rats. The experiments were carried out on 2-months-old albino male rats randomly divided into 6 group: Mn300 and Mn500-received solution of MnCl2 to drink (dose 300 and 500 mg/L, respectively), Gln group-solution of glutamine (4 g/L), Mn300-Gln and Mn500-Gln groups-solution of Mn at 300 and 500 mg/L and Gln at 4 g/L dose. The control group (C) received deionized water. Half of the animals were euthanized after three and the other half-after 6 weeks of experiment. The exposure of rats to Mn in drinking water contributes to diminishing of the antioxidant enzymes activity and the increase in level of lipid peroxidation. Glutamine in the diet admittedly increases SOD and GPx activity, but it is unable to restore the intracellular redox balance. The most significant differences in the examined amino acids levels in comparison to both control and Gln group were observed in the group of rats receiving Mn at 500 mg/L dose alone or with Gln. It seems that Gln is amino acid which could improve antioxidant status and affect the concentrations of the neurotransmitters.
Properties of Soundless Chemical Demolition Agents (1994)

The traditional approach to demolish concrete structures or to reduce the sizes of large rocks or boulders has typically included the use of explosives. The resulting explosions are associated with the obvious risks posed by shock waves and fly rock. These, along with other detrimental side effects of using explosives, have increased an interest in the use of alternative methods to demolish rock and concrete structures. Soundless chemical demolition agents (SCDAs) have proven to be viable substitutes for the use of explosives. SCDAs are powdery materials that will expand considerably when mixed with water. This expansion, when occurring under confinement, generates significant expansive pressures. These pressures are sufficient to break up rock and concrete when the SCDA is confined in a borehole or a series of boreholes. Experiments have been conducted with SCDAs to learn more about those variables that tend to hamper or enhance SCDA performance. Results show that the amount of mixing water and the ambient temperature are the most important variables in influencing the generation of SCDA expansive pressures.
Role of microglia in the central nervous system's immune response (2005)

Microglial cells comprise a network of endogenous immunocompetent cells that pervade the brain and spinal cord. The primary function of this system is to provide continuous surveillance of the parenchyma and protect the central nervous system (CNS) during injury and disease. Here we discuss the involvement of microglia during brain aging and aging-related neurodegenerative disease, i.e. Alzheimer's disease, and briefly summarize their possible roles in amyotrophic lateral sclerosis (ALS). In addition, we provide an overview of the neuroinflammation associated with primary brain tumors and how microglial tumor cytotoxicity could be targeted for immunotherapeutic approaches designed to treat these lesions.
La inversión extranjera directa en América Latina y las multinacionales emergentes latinoamericanas (2010)

Hepatitis C virus (HCV) is a leading cause of chronic hepatitis, with 170 to 190 million people infected worldwide. The treatment of choice for patients who have HCV-related cirrhosis with or without hepatocellular carcinoma is liver transplantation. Virologic recurrence is constant after transplantation and results in chronic hepatitis in the vast majority. HCV infection now can be cured in a substantial proportion of liver transplant recipients. This review highlights the available strategies to improve outcome, including modification of factors that affect disease progression and the efficacy of antiviral therapy.
A novel method for synthesizing PEGylated chitosan nanoparticles: strategy, preparation, and in vitro analysis (2011)

Preparation of poly (ethylene glycol) (PEG)-grafted chitosan is essential for improving the biocompatibility and water solubility of chitosan. Presently available methods for this have limitations. This article describes a new method for preparing PEGylated chitosan nanoparticles. For this chitosan was chemoselectively modified using a novel scheme at the C6 position of its repeating units by PEG. The amine groups at the C2 position of the chitosan were protected using phthalic anhydride. Sodium hydride was used to catalyze the etherification reaction between chlorinated chitosan and methyl-PEG, and PEG-grafted chitosan was successfully synthesized. Each step was characterized using 13C nuclear magnetic resonance and Fourier transform infrared. After PEGylation the phthaloylated chitosan was successfully deprotected using hydrazine monohydrate. The synthetic scheme proposed demonstrates a new method for grafting PEG onto chitosan with a moderate degree of substitution. The potential of this polymer in nanoparticle preparation using an ionic gelation method and its gene delivery potentials were investigated by complexing a fluorescently labeled control siRNA. The result showed that suitable nanoparticles can be synthesized using this polymer and that they have capacity to carry genes and provide adequate transfection efficacy with no toxicity when tested in neuronal cells.
Piezoelectric-based apparatus for strain tuning (2014)

We report the design and construction of piezoelectric-based apparatus for applying continuously tuneable compressive and tensile strains to test samples. It can be used across a wide temperature range, including cryogenic temperatures. The achievable strain is large, so far up to 0.23% at cryogenic temperatures. The apparatus is compact and compatible with a wide variety of experimental probes. In addition, we present a method for mounting high-aspect-ratio samples in order to achieve high strain homogeneity.
Oenothein B, a dimeric, hydrolysable tannin with macrocyclic structure, and accompanying tannins from Oenothera erythrosepala (1990)

A new dimeric, hydrolysable tannin which we have named oenothein B (1), and eight accompanying compounds, including oenothein C (2), were isolated from the leaves of Oenothera erythrosepala. The macrocyclic structure of compound (1) was established from chemical and spectroscopic data. The previously assigned structure of compound (2) was also confirmed by two-dimensional NMR spectroscopy.
논문 : 비용에 근거한 공항사용료 결정에 관한 연구 -항공기 착륙료 중심- (2003)

본 연구의 목적은 항공기 착륙료를 이착륙 서비스 지원에 투입된 비용을 각 운항 별로 유발한 비용수준에 따라 공정하게 배분하는 방법으로 산정하여 각 사용자에게 부담하도록 함으로써 현재 적용되고 있는 평균 비용에 근거한 요율 산정이나, 일부 학자들이 주장하고 있는 한계 비용에 의한 가격 결정 방법의 한계점을 보완할 수 있는 가격 결정 모델을 개발하는 데 있다. 원가회계 이론을 적용하여 각 이착륙 서비스 별 비용을 배정하는 방법을 적용하되 항공기 중량과 혼잡수준을 원가를 차별화 시키는 변수로 고려한다. 시설 제공에 투입된 비용은 평굴 비용의 원리를 적용하고 시설 운영비용은 한계 비용원리를 적용하여 각 운항서비스 별 총비용을 산정하여 착륙료를 부과함으로써 한계 비용에 의한 가격이 되도록 하면서도 합리적인 방법으로 총 비용을 회수 할 수 있도록 하는데 그 가치가 있다. 또한, 원가 원가 회계 원리를 적용하여 모델을 도출함으로써, 각 공항의 회계 자료를 이용하여 실제적으로 착륙료 계산이 가능한 모델을 제시할 수 있다는 장점도 있다.
The expected return on United Kingdom equities and an implication for pension fund valuations (1993)

Abstract The paper analyses the relationship between equities and gilt-edged. It shows that the yield ratio (the yield on gilts divided by that on equities) should no longer hold its almost mystical significance of the last decade, being but one component of the expected return on equities, in which the most significant element is the rate of dividend growth relative to the yield on gilt-edged. How equities perform in economic recession is highlighted. The paper reviews the performance of equities over the last 70 years in both nominal and real terms and analyses the historic sources of the equity risk premium, i.e. the excess return of equities over gilt-edged. If the equity risk premium remains at below-average levels in the 1990s, as is possible, constraints may be placed on actuaries' choice of pension fund valuation bases.
Facial 3D Shape Estimation from Images for Visual Speech Animation (2014)

In this paper we describe the first version of our system for estimating 3D shape sequences from images of the frontal face. This approach is developed with 3D Visual Speech Animation (VSA) as the target application. In particular, the focus is on the usability of an existing state-of-the-art image-based VSA system and subsequent on-line estimation of the corresponding 3D facial shape sequence from its output. This has the added advantage of a 3D visual speech, which is mainly render ability of the face in different poses and illumination conditions. The idea is based on the detection of landmarks from the facial image which are then used to determine the pose and shape. The method belongs to the category of methods which use a prior 3D Morph able Models (3D-MM) trained using 3D facial data. For the time being it is developed for a person-specific domain, i.e. the 3D-MM and the 2D facial landmark detector are trained using the data of a single person and tested with the same person-specific data.
The many faces of the helix-turn-helix domain: Transcription regulation and beyond (2005)

The helix-turn-helix (HTH) domain is a common denominator in basal and specific transcription factors from the three super-kingdoms of life. At its core, the domain comprises of an open tri-helical bundle, which typically binds DNA with the 3rd helix. Drawing on the wealth of data that has accumulated over two decades since the discovery of the domain, we present an overview of the natural history of the HTH domain from the viewpoint of structural analysis and comparative genomics. In structural terms, the HTH domains have developed several elaborations on the basic 3-helical core, such as the tetra-helical bundle, the winged-helix and the ribbon-helix-helix type configurations. In functional terms, the HTH domains are present in the most prevalent transcription factors of all prokaryotic genomes and some eukaryotic genomes. They have been recruited to a wide range of functions beyond transcription regulation, which include DNA repair and replication, RNA metabolism and protein-protein interactions in diverse signaling contexts. Beyond their basic role in mediating macromolecular interactions, the HTH domains have also been incorporated into the catalytic domains of diverse enzymes. We discuss the general domain architectural themes that have arisen amongst the HTH domains as a result of their recruitment to these diverse functions. We present a natural classification, higher-order relationships and phyletic pattern analysis of all the major families of HTH domains. This reconstruction suggests that there were at least 6-11 different HTH domains in the last universal common ancestor of all life forms, which covered much of the structural diversity and part of the functional versatility of the extant representatives of this domain. In prokaryotes the total number of HTH domains per genome shows a strong power-equation type scaling with the gene number per genome. However, the HTH domains in two-component signaling pathways show a linear scaling with gene number, in contrast to the non-linear scaling of HTH domains in single-component systems and sigma factors. These observations point to distinct evolutionary forces in the emergence of different signaling systems with HTH transcription factors. The archaea and bacteria share a number of ancient families of specific HTH transcription factors. However, they do not share any orthologous HTH proteins in the basal transcription apparatus. This differential relationship of their basal and specific transcriptional machinery poses an apparent conundrum regarding the origins of their transcription apparatus.
A functional tonB gene is required for both utilization of heme and virulence expression by Haemophilus influenzae type b (1994)

Haemophilus influenzae is nearly unique among facultatively anaerobic bacteria in its absolute requirement for exogenously supplied heme for aerobic growth. In this study, a mutant analysis strategy was used to facilitate identification of H. influenzae cell envelope components involved in the uptake of heme. Chemical mutagenesis was employed to produce a mutant of a nontypeable H. influenzae strain unable to utilize either protein-bound forms of heme or low levels of free heme. This mutant was transformed with a plasmid shuttle vector-based genomic library constructed from the same wild-type nontypeable H. influenzae strain, and a growth selection technique was used to obtain a recombinant clone that could utilize heme. Analysis of the DNA insert in the recombinant plasmid revealed the presence of several open reading frames, one of which encoded a 28-kDa protein with significant similarity to the TonB protein of Escherichia coli. This H. influenzae gene product was able to complement a tonB mutation in E. coli, allowing the E. coli tonB mutant to form single colonies on minimal medium containing vitamin B12. When this H. influenzae gene was inactivated by insertional mutagenesis techniques and introduced into the chromosome of wild-type strains of H. influenzae type b, the resultant transformants lost their abilities to utilize heme and produce invasive disease in an animal model. Genetic restoration of the ability to express this TonB homolog resulted in the simultaneous acquisition of both heme utilization ability and virulence. These results indicate that the H. influenzae TonB protein is required not only for heme utilization by this pathogen in vitro, but also for virulence of H. influenzae type b in an animal model.
A remote presentation agent for multimedia databases (2002)

The successful realization of distributed multimedia information systems depend on the ability to overcome the synchronization problems involved in the end-to-end presentation of multimedia information. In this paper we discuss multimedia synchronization at the source, network and user-interface levels of the distributed multimedia information systems. In order to resolve the synchronization problem we make use of a progressive retrieval strategy which sequentially retrieves independent synchronized entities from a multimedia document. This paper also presents an architecture for a multimedia presentation agent which synchronizes the multimedia document for playback. This multimedia presentation agent is designed to be an interactive server to a user-interface client.
Drilling Fluids Optimization: A Practical Field Approach (1986)

According to authors Lummus and Azar, the phrase ''implied or specific conditions'' is of key importance in planning a drilling venture, since these conditions dictate the degree of optimization which can be achieved. This book deals with such implied and specific restraints as the capabilities of the rig selected and those determined by the wellsite. Defining drilling optimization as ''the logical process of analyzing effects and interactions of drilling variables through mathematical modeling to achieve maximum drilling efficiency,'' the authors delineate this process for the reader. Numerous tables, charts and illustrations are also provided. One of the ways in which this book achieves its goal of providing a practical field approach to optimization is by supplying an optimum drilling program as an example. An appendix presents a sample program so that the reader can review the basic sections without becoming bogged down in detailed explanations on how the optimizer arrived at the various guidelines.
Abstract OT2-01-04: SOLAR-1: A phase III study of alpelisib and fulvestrant in men and postmenopausal women with hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2–) advanced breast cancer (BC) progressing on or after aromatase inhibitor (AI) therapy (2017)

Abstract Background: The phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) pathway is often dysregulated in HR+ BC and is associated with resistance to endocrine therapy (ET). Alpelisib (BYL719; PI3Kα-specific inhibitor) and fulvestrant showed signs of antitumor activity in patients (pts) with estrogen receptor-positive (ER+), HER2– advanced BC (phase I), especially in PIK3CA-altered tumors (Janku et al. SABCS 2014, PD5-5). Methods: SOLAR-1 (NCT02437318) is a phase III, randomized, double-blind study in men and postmenopausal women with HR+, HER2– advanced BC. Pts are assigned to 1 of 2 cohorts based on PIK3CA tumor status (mutant vs non-mutant), and randomized 1:1 to oral alpelisib/placebo (300 mg once daily) and intramuscular fulvestrant (500 mg on Day 1 and 15 of Cycle 1; Day 1 of Cycles ≥2 [28-day cycles]) until disease progression or discontinuation. Randomization is stratified by presence of liver and/or lung metastases and prior CDK4/6 inhibitor therapy. Key inclusion criteria: recurrence or progression on or after AI therapy, ≥1 measurable lesion (RECIST v1.1) or predominantly lytic bone lesion, and ECOG performance status ≤1. Key exclusion criteria: symptomatic visceral disease or disease burden precluding ET, acute pancreatitis ≤1 year prior to screening or history of chronic pancreatitis, and prior therapy with fulvestrant, chemotherapy (except [neo]adjuvant), or PI3K/AKT/mTOR inhibitors. The primary and key secondary endpoints are progression-free survival (PFS; RECIST v1.1; local assessment) and overall survival (OS), respectively, in the PIK3CA-mutant cohort. Other secondary endpoints include PFS and OS in the PIK3CA non-mutant cohort, PFS (Blinded Independent Central Review; RECIST v1.1), the association between PFS and baseline PIK3CA status in circulating tumor DNA, overall response rate, clinical benefit rate, safety, and pharmacokinetics. The primary endpoint will be analyzed by a stratified log-rank test at one-sided 2% level of significance. Recruitment of the planned 560 pts is ongoing. Citation Format: Andre F, Kaufman B, Juric D, Ciruelos EM, Iwata H, Mayer IA, Rugo HS, Conte P, Liobl S, Rubovszky G, Inoue K, Tesch H, Lu Y-S, Ryvo L, Longin A-S, Mills D, Wilke C, Germa C, Campone M. SOLAR-1: A phase III study of alpelisib and fulvestrant in men and postmenopausal women with hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2–) advanced breast cancer (BC) progressing on or after aromatase inhibitor (AI) therapy [abstract]. In: Proceedings of the 2016 San Antonio Breast Cancer Symposium; 2016 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2017;77(4 Suppl):Abstract nr OT2-01-04.
Cerebral (Cortical) Biostimulation (1986)

Presently, stimulation of the surface of the brain in order to provide artificial vision or hearing for the blind and deaf is in its infant stages. Those observations which are accumulating now have as their aim the investigation of the feasibility of such prosthetic devices. Whether such devices will ever be of real therapeutic benefit remains uncertain and can only be determined by this type of very labor-intensive, expensive and interdisciplinary investigation. When one considers, on the other hand, that there are between one-quarter and one-half million individuals in the United States and Canada who are profoundly deaf and a similar number who are legally blind, the value of the pursuit of such investigation requires little defense.
High Performance Conducting Polymer Nanofiber Biosensors for Detection of Biomolecules (2014)

Sensitive detection and selective determination of the physiologically important chemicals involved in brain function have drawn much attention for the diagnosis and treatment of brain diseases and neurological disorders. This paper reports a novel method for fabrication of enzyme entrapped-conducting polymer nanofibers that offer higher sensitivity and increased lifetime compared to glucose sensors that are based on conducting polymer films.