gebhart/patrepeval huggingface dataset:
Identification, characterization and cloning of myr 1, a mammalian myosin-I. (1993)

We have identified, characterized and cloned a novel mammalian myosin-I motor-molecule, called myr 1 (myosin-I from rat). Myr 1 exists in three alternative splice forms: myr 1a, myr 1b, and myr 1c. These splice forms differ in their numbers of putative calmodulin/light chain binding sites. Myr 1a-c were selectively released by ATP, bound in a nucleotide-dependent manner to F-actin and exhibited amino acid sequences characteristic of myosin-I motor domains. In addition to the motor domain, they contained a regulatory domain with up to six putative calmodulin/light chain binding sites and a tail domain. The tail domain exhibited 47% amino acid sequence identity to the brush border myosin-I tail domain, demonstrating that myr 1 is related to the only other mammalian myosin-I motor molecule that has been characterized so far. In contrast to brush border myosin-I which is expressed in mature enterocytes, myr 1 splice forms were differentially expressed in all tested tissues. Therefore, myr 1 is the first mammalian myosin-I motor molecule with a widespread tissue distribution in neonatal and adult tissues. The myr 1a splice form was preferentially expressed in neuronal tissues. Its expression was developmentally regulated during rat forebrain ontogeny and subcellular fractionation revealed an enrichment in purified growth cone particles, data consistent with a role for myr 1a in neuronal development.
Target Acquisition, Localization, and Surveillance Using a Fixed-Wing Mini-UAV and Gimbaled Camera (2006)

Target acquisition and continuous surveillance using fixed-wing UAVs is a difficult task due to the many degrees of freedom inherent in aircraft and gimbaled cameras. Mini-UAVs further complicate the problem by introducing severe restrictions on the size and weight of electro-optical sensor assemblies. We present a field-tested mini-UAV gimbal mechanism and flightpath generation algorithm as well as a human-UAV interaction scheme in which the operator manually flies the UAV to produce an estimate of the target position, then allows the aircraft to fly itself and control the gimbal while the operator re fines or moves the target position as required.
Distribution Characteristics of the Rainwater That Falls under the Canopy of the Tea Plant (2002)

樹冠下での効果的な施肥技術を考えるために,樹冠下への雨水の落下状況を調べた。樹冠下ではごく一部の場所に多量の雨水が落下したのに対し,その他大部分の場所ではわずかな水量しか認められなかった。うね間にはほぼ降雨量程度の水量がむらなく認められた。また,裾部付近の落下水量は降雨量に対して特別に増加することはなかった。多量の採水量が認められた部分を観察すると,枝の一部が下に突き出したような形状をしており,樹冠面に降り落ちた雨水が枝を伝ってこの部分に集中するため局所的な落下分布を示すものと考えられた。このような樹冠下への雨水落下様式は,仕立てや降雨量の多少に関わらず同様であった。また,主幹の株元に集まる雨水の量を測定した結果,樹冠面に落下した雨の4割程度が主幹株元に集中的に流れ落ちることがわかった。以上の結果,茶園における樹冠下への雨水落下は極めて局所的であることがわかり,施肥成分の動態も場所により大きく異なると予想された。
<i>N</i>-Alkyl Urea Hydroxamic Acids as a New Class of Peptide Deformylase Inhibitors with Antibacterial Activity (2002)

Peptide deformylase (PDF) is a prokaryotic metalloenzyme that is essential for bacterial growth and is a new target for the development of antibacterial agents. All previously reported PDF inhibitors with sufficient antibacterial activity share the structural feature of a 2-substituted alkanoyl at the P(1)' site. Using a combination of iterative parallel synthesis and traditional medicinal chemistry, we have identified a new class of PDF inhibitors with N-alkyl urea at the P(1)' site. Compounds with MICs of <or=4 micro g/ml against gram-positive and gram-negative pathogens, including Staphylococcus aureus, Streptococcus pneumoniae, and Haemophilus influenzae, have been identified. The concentrations needed to inhibit 50% of enzyme activity (IC(50)s) for Escherichia coli Ni-PDF were <or=0.1 micro M, demonstrating the specificity of the inhibitors. In addition, these compounds were very selective for PDF, with IC(50)s of consistently >200 micro M for matrilysin and other mammalian metalloproteases. Structure-activity relationship analysis identified preferred substitutions resulting in improved potency and decreased cytotoxity. One of the compounds (VRC4307) was cocrystallized with PDF, and the enzyme-inhibitor structure was determined at a resolution of 1.7 A. This structural information indicated that the urea compounds adopt a binding position similar to that previously determined for succinate hydroxamates. Two compounds, VRC4232 and VRC4307, displayed in vivo efficacy in a mouse protection assay, with 50% protective doses of 30.8 and 17.9 mg/kg of body weight, respectively. These N-alkyl urea hydroxamic acids provide a starting point for identifying new PDF inhibitors that can serve as antimicrobial agents.
Solid phase synthesis of C2,N6-disubstituted adenosine analogues (2002)

A 6-step solid phase sequence towards C2,N6-disubstituted adenosine analogues was developed, which was validated by the construction of a small combinatorial library. Attachment of the 5′-OH of readily available 2′,3′-methoxymethylidene protected 6-chloropurine ribonucleoside onto carboxypolystyrene furnished the immobilised 6-chloropurine ribonucleoside. Nitration on the solid phase resulted in the formation of the 2-nitro-6-chloropurine nucleoside, a highly reactive difunctionalised species. Amines were selectively introduced at the 6-position by 6-chloro displacement at room temperature without affecting the 2-nitro group. Subsequent substitution of the 2-nitro group by amines was achieved at 80–90 °C. Removal of the methoxymethylidene group under mildly acidic conditions, followed by cleavage of the nucleosides from the resin, yielded the C2,N6-disubstituted adenosine analogues.
Impacts of separate rejection water treatment on the overall plant performance (2003)

A separate rejection water treatment appears as a high-tech unit process which might be recommendable only for specific cases of an upgrading of an existing wastewater treatment plant. It is not the issue of this paper to consider a specific separate treatment process itself but to investigate the influence of such a process on the overall plant performance. A plant-wide model has been applied as an innovative tool to evaluate effects of the implemented sidestream strategy on the mainstream treatment. The model has been developed in the SIMBA environment and combines acknowledged mathematical descriptions of the activated sludge process (ASM1) and the anaerobic mesophilic digestion (Siegrist model). The model's calibration and validation was based on data from 5 years of operating experience of a full-scale rejection water treatment. The impact on the total N-elimination efficiency is demonstrated by detailed nitrogen mass flow schemes including the interactions between the wastewater and the sludge lane. Additionally limiting conditions due to dynamic N-return loads are displayed by the model's state variables.
Nanostructure determines the intensity-dependence of open-circuit voltage in plastic solar cells (2010)

We use photoconductive atomic force microscopy to make local measurements of the open-circuit voltage (VOC) as a function of light intensity in several polymer/fullerene bulk heterojunction blend solar cells. We find significant local variations in the slope of the open-circuit voltage plotted versus the log of the light intensity. By studying a model alkoxy-poly(p)-pheneylene-vinylene/phenyl-C61-butyric acid methyl ester system with known vertical structure, and by comparing our results with a simple numerical model, we associate these local differences in VOC versus light intensity with lateral variations in vertical morphology/composition. These results not only provide a qualitative method of mapping lateral variations in vertical structure/composition by making local measurements of VOC as a function of light intensity but suggest that the unusual light-intensity dependence of VOC (diode ideality factors in the light) of many organic photovoltaics can be linked with morphological heterogeneity.
Mycoplasma arthritidis-induced ocular inflammatory disease (1982)

Mycoplasma arthritidis was demonstrated to incite experimental conjunctivitis and uveitis in Swiss Webster mice which have a known susceptibility to the arthritis customarily associated with infection by this mycoplasma. The initial symptom of ocular involvement was conjunctivitis, which appeared as early as 1 day after intravenous injection with viable culture concentrates of M. arthritidis. By day 2, histological analysis showed intraocular localized inflammatory reactions that were confined primarily to the anterior portion of the uvea and produced results which were compatible with those seen in iridocyclitis. Serological assays of the titer and the class of antibodies involved in the early humoral immune response to infection confirmed the predominance of immunoglobulin G (IgG) concentrations over IgM concentrations that was described by others (Cole et al., Infect. Immun. 4:431-440, 1971) and revealed significant titers of the IgG2a and IgG2b subclasses of complement-fixing antibodies. The rapid onset of acute conjunctivitis, together with the early appearance of immunoglobulins of the IgG class, suggests that the M. arthritidis-infected Swiss Webster mice may have experienced an anamnestic response to the mycoplasma antigens. These observations introduce a new animal model for the study of mycoplasma-induced experimental uveitis and conjunctivitis, which are demonstrated here to accompany a disseminated systemic disease process.
Pathological Evaluation of Anti-rheumatic Drugs on Type II Collagen-induced Arthritis in DBA/1J Mouse (1991)

The effects of anti-rheumatic drugs (lobenzarit (CCA); 10 and 50mg/kg, cyclophosphamide (CP); 5 mg/kg and dexamethasone (DM); 0.25mg/kg) were evaluated immunologically and histopathologically on DBA/1J mice that develop polyarthritis after immunization by the intradermal injection of type II collagen. Serum anti-type II collagen IgG levels in the groups treated with CP and DM were significantly suppressed to 1/2 and 1/10 as compared to those of the positive control group, respectively. Those of both groups treated with CCA were not different from those of the positive control group. Histopathological examination revealed that treatment with CP and DM markedly reduced or suppressed inflammatory changes and resulted in low incidence of arthritis. From the standpoint mentioned above, treatment with anti-rheumatic drugs suppressed the development of arthritis in this model, and we could confirm that this model was useful for evaluation of the effect of anti-rheumatic drugs.
Phenotypic analysis of established diffuse histiocytic lymphoma cell lines utilizing monoclonal antibodies and cytochemical techniques (1984)

Ten diffuse histiocytic lymphoma (DHL) cell lines were extensively characterized with monoclonal antibodies and histochemical techniques. The original biopsy specimens, representing nine of ten cases from which the cell lines were derived, were reviewed utilizing the International Working Formulation. Eight of ten cell lines reacted with anti-immunoglobulin reagents and/or a subset of B-lymphocyte surface markers, supporting a B-cell derivation. Only U-937, a monocytoid DHL cell line reactive with OKT4 and 6, displayed any T-cell markers. Cytochemical analysis alone proved to be of little value in the subclassification of the DHLs. The pathologic review revealed that, despite disparate immunologic phenotypes, five of the diffuse large cell lymphomas were subclassified as large, noncleaved lymphomas. Our analysis confirms the phenotypic diversity of this subgroup of malignant lymphomas and underscores the value of monoclonal reagents for the immunologic evaluation of the hematologic malignancies. These well characterized cell lines constitute a valuable resource for the laboratory investigation of the lymphomas.
Study on Damage Mechanism of Pipe Using Ultrasonic Wave and Acoustic Emission Technique (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Autologous Marrow Injection as a Substitute for Operative Grafting of Tibial Nonunions (1991)

Autologous marrow injection was used to stimulate healing in 20 ununited tibial fractures over a five-year period. The technique was employed in conjunction with cast immobilization in ten cases and intramedullary nail fixation in ten cases. Marrow stimulated a callus formation sufficient to unite eight of the ten nonunions immobilized with casts and all ten of the fractures immobilized by intramedullary nails. Bone-marrow injection was as effective as past open autologous grafting but with considerably fewer disadvantages. The technique provides a promptly renewable and reliable source of osteogenic stem cells with numerous advantages compared with standard open-grafting techniques.
On State Feedback H<sub>∞</sub> Control for Discrete-Time Singular Systems (2013)

This technical note deals with the state feedback H <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">∞</sub> control problem for linear time-invariant discrete-time singular systems. Relied on the use of auxiliary matrices and a positive scalar, a novel necessary and sufficient condition for the bounded real lemma is derived for discrete-time singular systems. The characterization is reduced to a strict linear matrix inequality (LMI) when the scalar is fixed, and the resulting LMI is non-conservative as long as the scalar is chosen sufficiently large. Moreover, the result is further expanded to H <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">∞</sub> controller design, and a numerically efficient and reliable design procedure is given. Since no particular restriction is imposed on the auxiliary matrices, the proposed result outperforms the existing methods in the literature. Numerical examples are included to illustrate the effectiveness of the present result.
Vapor-liquid equilibria at 760 mmHg in the system methanol-1,1-dichloroethane (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTVapor-liquid equilibria at 760 mmHg in the system methanol-1,1-dichloroethaneJaime Wisniak and Abraham TamirCite this: J. Chem. Eng. Data 1988, 33, 2, 109–111Publication Date (Print):April 1, 1988Publication History Published online1 May 2002Published inissue 1 April 1988https://pubs.acs.org/doi/10.1021/je00052a014https://doi.org/10.1021/je00052a014research-articleACS PublicationsRequest reuse permissionsArticle Views46Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
150°C heat- and oil-resistant TPVs- long-term fluid and spike temperature comparison (2004)

New families of thermoplastic vulcanizates (TPVs) were commercially introduced in early 2003 offering 150°C heat and oil resistance in excess of 3000hrs. These TPVs are based on a continuous phase polyamide thermoplastic matrix and dynamically vulcanized polyacrylate (ACM) elastomer. Applications have a broad interest from underhood automotive to industrial applications. The heat and oil resistance of a commercialized TPV from this family will be compared at 150°C to conventional and silicone-based TPVs in addition to an ethylene-acrylate (AEM) thermoset elastomer, all of similar initial physical properties. Degradation after 175°C spike temperature exposure to air and an assortment of automotive fluids will also be compared. Finally, an overall comparison will be made to qualitatively measure the equivalency of these materials in manufacturing and end use application.
Autonomic dysfunction in chronic liver disease (2009)

Autonomic dysfunction (AD) is common in chronic liver disease (CLD) of all aetiologies and even more so in those awaiting transplantation. As yet, the pathophysiology is not completely understood but the clinical effects are dramatic for the patient, who has a heavy symptomatic burden. There are several considerations, specific to liver disease, which complicate AD. Outlined here is a practical guide for clinicians detailing the common presentations and consequences of AD, investigation techniques and treatment options. As morbidity and mortality is increased in CLD patients with AD its recognition, investigation and management is important to all who encounter such patients.
Reservoir Boundary Identification from Seismic Imaging for Well Test Analysis (1993)

Abstract Given a well test, the aim of this paper is to demonstrate that the range of possible reservoir boundaries derived from a seismic image is a valid constraint in the reservoir response. A lens model was considered. Synthetic seismic and well test data were generated. The focus was to verify that the single phase well test response is sensitive to modifications of the reservoir boundaries derived from a poststack seismic depth image, all the other variables being fixed. A specific prototype software was developed to implement the proposed methodology.
Properties of Symmetric Quadrupole Magnet Triplets (1965)

A number of studies have been made of quadrupole magnet systems. The properties of the single quadrupole are simple and are well documented. The quadrupole doublet, consisting of two aligned magnets of equal length but of opposite polarities, has been studied extensively by W. F. Baker who has presented his results in graphical form. This report is intended to present, in a fashion similar to Baker's, properties of symmetric quadrupole triplets.
An adaptive communication architecture for wireless sensor networks (2007)

As sensor networks move towards increasing heterogeneity, the number of link layers, MAC protocols, and underlying transportation mechanisms increases. System developers must adapt their applications and systems to accommodate a wide range of underlying protocols and mechanisms. However, existing communication architectures for sensor networks are not designed for this heterogeneity and therefore the system developer must redevelop their systems for each underlying communication protocol or mechanism. To remedy this situation, we present a communication architecture that adapts to a wide range of underlying communication mechanisms, from the MAC layer to the transport layer, without requiring any changes to applications or protocols. We show that the architecture is expressive enough to accommodate typical sensor network protocols. Measurements show that the increase in execution time over a non-adaptive architecture is small.
Dynamic Self-Backhauling in 5G Networks (2018)

The continuing growth in traffic demands impose the need for the use of frequency bands in the centimeter-wave (cmWave) and millimeter-wave (mmWave) spectrum to increase the throughput. However, this leads to challenges in the system design because of the need for higher cell densification as well as cost-effective deployment. To overcome these challenges the concept of wireless self-backhauling can be used to provide high-capacity network at reduced cost. In this paper, we investigate the performance of self-backhauling with flexible reuse of the resources for access and backhaul in a real-life street canyon scenario with dynamic blockages. The simulation results show that highly flexible access/backhaul and uplink/downlink scheduling with centralized coordination achieves significant throughput gain in median and 5 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sup> percentile of uplink (UL) and downlink (DL). Simulation based results also show that with the limitation of TDD flexibility, self-backhauling mainly provides uplink 5 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sup> percentile throughput gain.
Community hospitals (1986)

The Royal College of Nursing would like to hear from nurses involved in community hospitals. In the past there have been a few community hospitals which contained a number of GP and community nurse ‘owned’ beds. This is often a nurse-led initiative which should be expanded. Similarly, if you have been working in a community hospital for some years now, ie before the NHS and Community Care Act, please drop me a line describing the nurses’ role in relation to who is able to gain admission to the hospital in the first place. If community hospitals do not exist in your area, but you are aware that discussions are taking place with regard to the possibility of establishing one, please let me know.
In Vitro Model of Neuroinflammation: Efficacy of Cannabigerol, a Non-Psychoactive Cannabinoid (2018)

Inflammation and oxidative stress play main roles in neurodegeneration. Interestingly, different natural compounds may be able to exert neuroprotective actions against inflammation and oxidative stress, protecting from neuronal cell loss. Among these natural sources, <i>Cannabis sativa</i> represents a reservoir of compounds exerting beneficial properties, including cannabigerol (CBG), whose antioxidant properties have already been demonstrated in macrophages. Here, we aimed to evaluate the ability of CBG to protect NSC-34 motor neurons against the toxicity induced from the medium of LPS-stimulated RAW 264.7 macrophages. Using MTT assay, we observed that CBG pre-treatment was able to reduce the loss of cell viability induced by the medium of LPS-stimulated macrophages in NSC-34 cells. Indeed, CBG pre-treatment inhibited apoptosis, as shown by the reduction of caspase 3 activation and Bax expression, while Bcl-2 levels increased. Furthermore, CBG pre-treatment counteracted not only inflammation, as demonstrated by the reduction of IL-1β, TNF-α, IFN-γ and PPARγ protein levels assessed by immunocytochemistry, but also oxidative stress in NSC-34 cells treated with the medium of LPS-stimulated RAW 264.7. Indeed, immunocytochemistry showed that CBG pre-treatment reduced nitrotyrosine, SOD1 and iNOS protein levels and restored Nrf-2 levels. All together, these results indicated the neuroprotective effects of CBG, that may be a potential treatment against neuroinflammation and oxidative stress.