gebhart/patrepeval huggingface dataset:
Avian Influenza Virus Hemagglutinin Display on Baculovirus Envelope: Cytoplasmic Domain Affects Virus Properties and Vaccine Potential (2007)

Hemagglutinin (HA) is the major immunogen on the envelope of avian influenza virus (AIV). Therefore we constructed two recombinant baculoviruses: Bac-HA, expressing histidine-tagged HA with the cytoplasmic domain (CTD) derived from HA, and Bac-HA64, expressing histidine-tagged HA with the CTD derived from baculovirus envelope protein gp64. After infection, HA with either CTD was expressed and anchored on the plasma membrane of Sf-9 cells, as revealed by confocal microscopy. Immunogold electron microscopy demonstrated that both Bac-HA and Bac-HA64 displayed HA on the viral surface. However, analyses of purified viruses revealed that significantly more HA was incorporated into Bac-HA64 than into Bac-HA. In comparison with Bac-HA, Bac-HA64 significantly improved the gene delivery and transgene expression in mammalian cells, as determined by quantitative real-time polymerase chain reaction and flow cytometry. Bac-HA64 elicited significantly higher hemagglutination inhibition titers in mouse models than Bac-HA and the negative controls. These data collectively confirmed that the gp64 CTD, in comparison with HA CTD, resulted in more efficient HA incorporation into baculovirus, more efficient transgene delivery and expression, and elevated immunogenicity. This is the first report demonstrating the potential of HA-pseudotyped baculovirus as an avian influenza vaccine and that the choice of CTD tremendously affects baculovirus properties and vaccine efficacy.
Specificity of Leptin Action on Elevated Blood Glucose Levels and Hypothalamic Neuropeptide Y Gene Expression in <i>ob/ob</i> Mice (1996)

Correction of the obese state induced by genetic leptin deficiency reduces elevated levels of both blood glucose and hypothalamic neuropeptide Y (NPY) mRNA in ob/ob mice. To determine whether these responses are due to a specific action of leptin or to the reversal of the obese state, we investigated the specificity of the effect of systemic leptin administration to ob/ob mice (n = 8) on levels of plasma glucose and insulin and on hypothalamic expression of NPY mRNA. Saline-treated controls were either fed ad libitum (n = 8) or pair-fed to the intake of the leptin-treated group (n = 8) to control for changes of food intake induced by leptin. The specificity of the effect of leptin was further assessed by 1) measuring NPY gene expression in db/db mice (n = 6) that are resistant to leptin, 2) measuring NPY gene expression in brain areas outside the hypothalamus, and 3) measuring the effect of leptin administration on hypothalamic expression of corticotropin-releasing hormone (CRH) mRNA. Five daily intraperitoneal injections of recombinant mouse leptin (150 micrograms) in ob/ob mice lowered food intake by 56% (P < 0.05), body weight by 4.1% (P < 0.05), and levels of NPY mRNA in the hypothalamic arcuate nucleus by 42.3% (P < 0.05) as compared with saline-treated controls. Pair-feeding of ob/ob mice to the intake of leptin-treated animals produced equivalent weight loss, but did not alter expression of NPY mRNA in the arcuate nucleus. Leptin administration was also without effect on food intake, body weight, or NPY mRNA levels in the arcuate nucleus of db/db mice. In ob/ob mice, leptin did not alter NPY mRNA levels in cerebral cortex or hippocampus or the expression of CRH mRNA in the hypothalamic paraventricular nucleus (PVN). Leptin administration to ob/ob mice also markedly reduced serum glucose (8.3 +/- 1.2 vs. 24.5 +/- 3.8 mmol/l; P < 0.01) and insulin levels (7,263 +/- 1,309 vs. 3,150 +/- 780 pmol/l), but was ineffective in db/db mice. Pair-fed mice experienced reductions of glucose and insulin levels that were < 60% of the reduction induced by leptin. The results suggest that in ob/ob mice, systemic administration of leptin inhibits NPY gene overexpression through a specific action in the arcuate nucleus and exerts a hypoglycemic action that is partly independent of its weight-reducing effects. Furthermore, both effects occur before reversal of the obesity syndrome. Defective leptin signaling due to either leptin deficiency (in ob/ob mice) or leptin resistance (in db/db mice) therefore leads directly to hyperglycemia and the overexpression of hypothalamic NPY that is implicated in the pathogenesis of the obesity syndrome.
Enabling tenant-aware administration and management for JBI environments (2012)

Enterprise Service Buses (ESBs) constitute a core middleware technology for each modern Service-Oriented Architecture (SOA) solution. Given the popularity of the Cloud paradigm, which is based on fundamental SOA concepts, it is only therefore natural to look into how ESBs can be transformed into native building blocks for Cloud platforms. As a first step of this effort, in this work we investigate how ESBs can become multi-tenant aware, i.e. able to support multiple tenants and their users sharing the same ESB instance. A generalized architecture based on the JBI specification implemented by a number of open source ESBs is presented for this purpose. We demonstrate the feasibility of our proposal by means of a proof of concept realization and we evaluate the performance of our solution against a non multi-tenant ESB that was used as the baseline for our implementation.
Learning of grasp adaptation through experience and tactile sensing (2014)

To perform robust grasping, a multi-fingered robotic hand should be able to adapt its grasping configuration, i.e., how the object is grasped, to maintain the stability of the grasp. Such a change of grasp configuration is called grasp adaptation and it depends on the controller, the employed sensory feedback and the type of uncertainties inherit to the problem. This paper proposes a grasp adaptation strategy to deal with uncertainties about physical properties of objects, such as the object weight and the friction at the contact points. Based on an object-level impedance controller, a grasp stability estimator is first learned in the object frame. Once a grasp is predicted to be unstable by the stability estimator, a grasp adaptation strategy is triggered according to the similarity between the new grasp and the training examples. Experimental results demonstrate that our method improves the grasping performance on novel objects with different physical properties from those used for training.
Seismic imaging of massive sulfide deposits; Part I, Rock properties (1996)

Laboratory measurements of the density (rho ) and compressional wave velocity (v P ) of massive sulfides and host rocks at elevated pressures show that ores occupy a V P - rho field which is distinct from that of common silicate rocks and governed by simple mixing rules between the properties of host rocks and pure sulfide minerals. The velocities of the most common sulfides are extremely variable, ranging from 3.7 km/s for galena, through 4.7 km/s for pyrrhotite, 5.6 km/s for sphalerite and chalcopyrite, to 8.0 km/s for pyrite, but their densities are always high (7.6, 4.6, 4.1 - 4.2, and 5.0 g/cc, respectively), causing ores of even intermediate grade to have high acoustic impedances. This suggests that large massive sulfide bodies should make strong to spectacular seismic reflectors, depending on their grade, mineralogy, size, and setting. In principle, it should thus be possible to use high-resolution seismic reflection techniques for base metal exploration and delineation.
Trends in Graphic Display Design (1976)

This paper discusses progress in the design of graphic displays, as seen from the viewpoint of the graphics system designer. In the first of three parts, the paper outlines the development of line-drawing displays, and explains why attention is presently focused on buffered transformation processors. The second part discusses raster-scan CRT displays, and compares several solutions to the problems of scan conversion and storage for refresh. The third part reviews some issues in the design of new display devices, and relates these to the functional characteristics of the graphic display.
Removal of Shadows and Reflections in the Images By Using Cross-Projection Tensors (2012)

We propose a new technique for removal of shadow and reflections in the images. We introduce cross projection tensors to achieve affine transformations of gradient fields. We used these tensors, to remove reflections in an image based on the edge of a second image information. Traditionally, the removal of the edges is achieved by setting the image gradients to zero on the basis of thresholds. One common application is in the Retinex problem, which recovers the illumination map the edges of the suppression of reflection, assuming that varies slowly. We present a class of problems in which edge suppression can be a useful tool. The key idea of our approach is to obtain local tensors with an image and to transform the gradient field of another image with them. Reconstructed image of the modified gradient field shows suppressed edges or textures in the appropriate places. All operations are local and our approach does not require any global analysis. We show that the algorithm in the context of applications such as: a) Elimination of shadows of color images and obtaining the illumination map b) Removing glass reflections.
DESALTING TECHNOLOGY IN POLLUTION‐CONTROL PROBLEMS (1971)

The purpose of this paper is to examine the current and possibly future role of desalting technology in water pollution control.
HEUI - A New Direction for Diesel Engine Fuel Systems (1993)

<div class="htmlview paragraph">Caterpillar Inc. has developed a new diesel engine fuel system, powered by hydraulics and controlled electronically. This Hydraulic Electronic Unit Injector, (HEUI), requires no mechanical actuating or mechanical control devices, and offers many advantages over conventional fuel injection systems.</div> <div class="htmlview paragraph">Inherent features of the HEUI Fuel System include injection pressure control independent of engine load or speed, totally flexible injection timing, and full electronic control of injection parameters. Packaging the HEUI Fuel System on an engine is simple, as the injector is compact and available in a variety of configurations. The hydraulic actuating circuit is straightforward, using lubricating oil from the engine sump. Hydraulic lines may be internal to the engine or external.</div> <div class="htmlview paragraph">This paper describes the Caterpillar HEUI Fuel System, its operating features, performance advantages, and application to diesel engines. System performance is compared to conventional mechanical and electronic unit injected fuel systems. HEUI characteristics are also compared to future fuel system requirements of the diesel engine as determined by a Quality Function Deployment (QFD) process.</div>
Robotic colorectal surgery: hype or new hope? A systematic review of robotics in colorectal surgery (2009)

Robotic colorectal surgery is a promising field and may provide a powerful additional tool for optimal management of more challenging pathology, including rectal cancer. Further studies are required to better define its role.
Value of Peanut Skins (Testa) as a Feed Ingredient for Growing-Finishing Swine (1981)

Thirty-six growing-finishing crossbred pigs (average weight 21.6 kg) were individually housed and fed diets containing 0, 10 or 20% peanut skins (testa) and the value of the skins as a feed ingredient was assessed. Significant linear effects on weight gain and average daily gain (ADG) were obtained with increasing dietary levels of peanut skins. Pigs fed diets containing 20% peanut skins had 15% lower (P< .05) ADG than control pigs. Highly significant curvilinear effects on feed intake and feed required per unit of gain were observed in response to dietary level of peanut skins. Pigs fed diets with 20% peanut skins consumed 23% more (P<.01) feed and required 31% more (P<.01) feed per unit of gain than did controls. Nine barrows (average weight 17.7 kg) were used in a digestion and N balance trial consisting of three 3 × 3 Latin squares such that each pig received each treatment during the trial. Highly significant linear effects on digestion coefficients for dry matter and crude protein due to increasing dietary level of peanut skins were observed. The digestion coefficient for crude protein was reduced (P<.01), by 43% when 20% peanut skins Was added to the diet. Digestion coefficients for ether extract were similar (P>.05) at all dietary levels of peanut skins. Highly significant linear effects on N metabolism were observed with increasing dietary levels of peanut skins. N excreted in urine and N balance were decreased (P<.01) with each increment of peanut skins, while N excreted in the feces was increased (P<.01).
Integrated micro ring resonator displacement sensor for scanning probe microscopies (2003)

We describe a novel displacement sensor for scanning probe microscopies using an integrated optical micro ring resonator. This device operates by means of monitoring the changes in the transmission spectrum of a high finesse micro ring resonator. Finite element method simulations were carried out to obtain the optimum sensor design and finite difference time domain simulation was used to obtain the transfer characteristics of micro ring resonators. Operation principles and sensitivity calculations are discussed in detail. To achieve high sensitivity, we have studied different types of ring resonator. The highest sensitivity is obtained in a race-track resonator. This new design should provide sensitivities as high as 10 -4 -1 .
Risk factors for anastomotic leakage after anterior resection of the rectum (2004)

In this population based study, 12% of the patients had symptomatic anastomotic leakage after anterior resection of the rectum. Postoperative 30-day mortality was 2.1%. Low anastomosis, pre-operative radiation, presence of intra-operative adverse events and male gender were independent risk factors for symptomatic anastomotic leakage in the multivariate analysis. There was no difference in the use of temporary stoma in patients with or without anastomotic leakage.
Identity access management for Multi-tier cloud infrastructures (2014)

This paper presents a novel architecture to manage identity and access (IAM) in a Multi-tier cloud infrastructure, in which most services are supported by massive-scale data centres over the Internet. Multi-tier cloud infrastructure uses tier-based model from Software Engineering to provide resources in different tires. In this paper we focus on design and implementation of a centralized identity and access management system for the multi-tier cloud infrastructure. First, we discuss identity and access management requirements in such an environment and propose our solution to address these requirements. Next, we discuss approaches to improve performance of the IAM system and make it scalable to billions of users. Finally, we present experimental results based on the current deployment in the SAVI Testbed. We show that our IAM system outperforms the previously proposed IAM systems for cloud infrastructure by factor 9 in throughput when the number of users is small, it handle about 50 times more requests in peak usage. Because our architecture is a combination of Green-thread and load balanced process, it uses less systems resources, and easily scales up to address high number of requests.
A new family of loss-less power MOSFET drivers (2002)

In this paper, a new family of lossless drivers for power MOS control is proposed. As is well known, the MOS input equivalent circuit is nearly a true capacitor. A new strategy for recovering energy in this capacitor based on DC/DC power converters is proposed. The authors present analysis and simulations, using the AWB (Analog Work-Bench software) package, of this new driver as well as a comparison with a traditional circuit. Finally, conclusions and future work are also presented.
Inhibition of the cellular secretion of cholesteryl ester transfer protein by a variant protein formed by alternative splicing of mRNA (1993)

Alternative splicing of mRNA is often used as a regulatory switch, determining whether a functional protein is made or not. The plasma cholesteryl ester transfer protein (CETP) mediates the transfer of cholesteryl esters from high density lipoproteins to other lipoproteins. In addition to the mRNA encoding plasma CETP, human tissues contain an alternatively spliced variant in which exon 9-derived sequences are omitted. To determine a possible regulatory role of alternative splicing, COS cells were co-transfected with full-length and exon 9-deleted cDNAs. The exon 9-deleted protein was poorly secreted and inhibited the secretion of full-length CETP, due to formation of an intracellular heteromeric complex between full-length and exon 9-deleted proteins. The findings suggest a novel use of alternative splicing to generate a poorly secreted protein variant, which complexes with the active form and prevents its secretion by cells.
Covalent Attachment of Gold Nanoparticles to DNA Templates (2002)

Functionalized gold nanoparticles have been covalently bound to internal, modified sites on double-stranded DNA. Gold nanoparticles coated with mercaptosuccinic acid or thioctic acid were bound to amino-modified thymine bases on double-stranded DNA. Visible absorption spectra, gel electrophoresis, and atomic force microscopy were used to analyze the products. Thiol groups were added to one end of the gold/nanoparticle product, which was then attached to a gold surface. This method has the potential to allow controlled placement of particles with subnanometer precision and to allow attachment of the product to fixed contacts for nanodevice fabrication.
New Diagnostic Approaches for Early Detection of Gastric Cancer (2004)

Detection of gastric cancer in early stages is vitally important for ascertaining better prognosis and quality of life for the patients. Therefore, every endoscopist should be trained to master enough diagnostic skills to identify early gastric cancer that often shows minimal alteration from the surrounding mucosa, easily evading detection. For the first step, it is essential that endoscopists understand the normal gastric mucosa as well as the mucosal changes caused by chronic H. pylori infection, a high-risk condition for the development of gastric cancer. Once a suspicious lesion is identified, use of a dye-spraying method may be useful to clarify structural alteration caused by neoplastic changes and facilitate the biopsy sampling. Development of zoom (magnifying) endoscopy enabling 80x magnification with a one-touch switch from conventional endoscopic observation helps to identify the detailed surface structure as well as the vascular architecture of the mucosa without tissue biopsy. Combined with chromoendoscopy, this powerful endoscopic method can be used to identify small cancer foci or delineate the margin of early gastric cancer that can be treatable by mucosal dissection. Other new modalities using a variety of optical devices have been developed but the real value of their utility still remains to be proven in the actual clinical settings.
An FPGA-Based LDPC Decoder With Ultra-Long Codes for Continuous-Variable Quantum Key Distribution (2021)

In this paper, we propose a good decoding performance, low-complexity, and high-speed decoder architecture for ultra-long quasi-cyclic LDPC codes by using the layered sum-product decoding scheme. To reduce implementation complexity and hardware resource consumption, the messages in the iteration process are uniformly quantified and the function Ψ(x) is approximated with second-order functions. The decoder architecture improves the decoding throughput by using partial parallel and pipeline structures. A modified construction method of parity check matrices was applied to prevent read&write conflicts and achieve high-speed pipeline structure. The simulation results show that our decoder architecture has good performance at signal-to-noise ratios (SNRs) as low as -0.6 dB. We have implemented our decoder architecture on a Virtex-7 XC7VX690T field programmable gate array (FPGA) device. The implementation results show that the FPGA-based LDPC decoder can achieve throughputs of 108.64 Mb/s and 70.32 Mb/s at SNR of 1.0 dB when the code length is 262,144 and 349,952, respectively. The decoder can find useful applications in those scenarios that require very low SNRs and high throughputs, such as the information reconciliation of continuous-variable quantum key distribution.
Antigen recognition during progression from acute to chronic infection with a cagA-positive strain of Helicobacter pylori (1996)

We have previously published two reports on acute infection with Helicobacter pylori, one of an adult male and one of a family of four. In the present study, we have isolated H.pylori from each of twin boys in the family and compared these by use of random amplified polymorphic DNA PCR. In addition, we have monitored the antibody response over time of the family and the adult male by Western blotting (immunoblotting) with two different strains of H. pylori as the antigen and by use of a commercial kit. The acutely infected twin boys were infected by an identical strain of H. pylori. The twin boys responded to antigens of 19, 26.5, and 29 kDa 30 days after the initial diagnosis, with recognition of 43-to 49-, 66-, 69-, and 87-kDa antigens by day 63. One twin responded to the CagA antigen on day 63, whereas the other responded on day 857. Antibody to the CagA antigen was not detected by use of the infecting strain, UNSW-RU1. Investigation of UNSW-RU1 revealed the presence of cagA. In two acutely infected adults (one, the father of the boys), the initial response to a 45-kDA antigen was later followed by responses to 19-, 29-, 49-, 60-, 77-, and 84-kDa antigens. Sera from the twins' younger sister, born 17 months after the twins acute episode, indicated that she also had become infected. This report supports intrafamilial transmission of H. pylori. Initial antibody responses in the children were to small-molecular-size antigens; in the adults, the initial responses were to larger-molecular-size antigens. The pattern of the serological response differs according to the antigen used. This has implications in regard to international data comparisons.
[Lipoprotein-dependent synthesis of prostacyclin in smooth muscle cells]. (1988)

Low (LDL) and high density lipoproteins (HDL) stimulated prostacycline (PGI2) synthesis in rabbit and human aorta smooth muscle cells growing in culture. The lipoproteins were added to the cells in concentrations equal to that of cholesterol. It was shown that HDL exerted a stronger stimulating effect as compared to LDL. The maximal effect was observed with HDL3. HDL3 isolated from blood serum of healthy volunteers appeared to be more active in PGI2 synthesis promotion than those of CDH patients with documented coronary atherosclerosis. Purified Apo A-1 stimulated the transformation of [14C]arachidonic acid into the products of its metabolism with increased accumulation of 6-keto-PGF1 alpha among labeled metabolites. Estradiol (1.10(-7) M) showed a stimulating effect; norepinephrine (1.10(-6) M) and progesterone (1.10(-7) M) showed an inhibiting effect, whereas corticosterone (1.10(-6) M) and deoxycorticosterone (1.10(-6) M) did not influence the rate of LDL-dependent PGI2 synthesis.