gebhart/patrepeval huggingface dataset:
Voltage balancing control of a three-phase hybrid-clamped five-level inverter based on optimal zero-sequence voltage injection (2014)

As the society pursuing for a more efficient way of using energy, the technology of multilevel converter, which aims at the field of large-power high-voltage, has been widely studied. In this paper, a newly released single phase hybrid-clamped five-level inverter has been extended to three phases. The characteristics of this topology and the switching states have been analyzed. To solve the voltage balance problem of the DC-bus capacitors and flying capacitors, a control strategy based on optimal zero-sequence voltage injection has been proposed. The strategy selects the optimal switching combinations according to their influences on the voltages of capacitors. With the injection of zero-sequence voltage, we can extend the voltage balance region of this topology compared to the existing control method. The proposed control strategy has been verified in simulations and experiments. Furthermore, the control strategy is a universal strategy which can be applied into other multilevel converters.
The Emerging Role of Atrial Natriuretic Peptide in Psychiatry (2020)

Further studies are necessary to understand the possible implications of ANP in neuropsychiatry, because potentially it might represent a new way for innovative psychopharmacological treatments in different conditions, all underlaid by hyperactive HPA axis.
Effects of Split-night Temperatures, Light, and Chlormequat on Growth and Carbohydrate Status of Pelargonium × hortorum (1984)

Abstract Seedlings (72 or 48 days old) of Pelargonium × hortorum cv. Red Elite were grown in 1 experiment from the 6th leaf stage in controlled-environment (CE) rooms at 4 temperatures, including 2 split-night (SN) regimes and at 3 daily-light integrals; in a 2nd experiment they were grown at 2 temperatures including one SN regime, at 3 daily-light integrals, and with and without chlormequat soil drench. Each of the 2 night-temperature periods were of equal duration in the SN regimes. Plants grown under the SN regimes were either similar in growth and reproductive development to plants grown under constant night conditions, where the temperature was the mean of the 2 SN temperatures, or were generally intermediate in growth and development to plants grown throughout the night at each of the 2 temperatures used in the SN regime. A daily mean temperature of 20°C compared to 16.8° or 18° reduced the time between the 6th leaf and macrobud visible stages by 8 days. Leaf starch and sugar levels decreased as mean daily temperatures increased, but increased as daily-light integrals increased. Drenches of (2-chloroethyl)-trimethylammonium chloride (chlormequat) applied at the 6th leaf stage limited plant height and leaf area without influencing flowering date.
Suppression of the Interferon-Mediated Innate Immune Response by Pseudorabies Virus (2006)

Pseudorabies virus (PRV) is an alphaherpesvirus related to the human pathogens herpes simplex virus type 1 (HSV-1) and varicella-zoster virus. PRV is capable of infecting and killing a wide variety of mammals. How it avoids innate immune defenses in so many hosts is not understood. While the anti-interferon (IFN) strategies of HSV-1 have been studied, little is known about how PRV evades the IFN-mediated immune response. In this study, we determined if wild-type PRV infection can overcome the establishment of a beta interferon (IFN-beta)-induced antiviral state in primary rat fibroblasts. Using microarray technology, we found that the expression of a subset of genes normally induced by IFN-beta in these cells was not induced when the cells were simultaneously infected with a wild-type PRV strain. Expression of transcripts associated with major histocompatibility complex class I antigen presentation and NK cell activation was reduced, while transcripts associated with inflammation either were unaffected or were induced by viral infection. This suppression of IFN-stimulated gene expression occurred because IFN signal transduction, in particular the phosphorylation of STAT1, became less effective in PRV-infected cells. At least one virion-associated protein is involved in inhibition of STAT1 tyrosine phosphorylation. This ability to disarm the IFN-beta response offers an explanation for the uniform lethality of virulent PRV infection of nonnatural hosts.
Nondeletional T-Cell Receptor Transgenic Mice: Model for the CD4<sup>+</sup>T-Cell Repertoire in Chronic Hepatitis B Virus Infection (2000)

Chronicity after infection with the hepatitis B virus (HBV) can occur for a variety of reasons. However, once established, chronicity may be maintained by high levels of viral proteins circulating in the serum. To examine the characteristics of T cells capable of coexisting with the secreted hepatitis B e antigen (HBeAg), T-cell receptor (TCR) transgenic (Tg) mice were produced. To ensure that HBeAg-specific T cells would not be deleted in the presence of serum HBeAg, the TCR alpha- and beta-chain genes used to produce the TCR-Tg mice were derived from T-cell hybridomas produced from immunizing HBeAg-Tg mice. A TCR-Tg lineage (11/4-12) was produced that possessed a high frequency ( approximately 67%) of CD4(+) T cells that expressed a Tg TCR specific for the HBeAg. As predicted, when 11/4-12 TCR-Tg mice were bred with HBeAg-Tg mice no deletion of the HBeAg-specific CD4(+) T cells occurred in the thymus or the spleen. Functional analysis of the TCR-Tg T cells revealed that the HBeAg-specific CD4(+) T cells escaped deletion in the thymus and periphery by virtue of low avidity. Regardless of their low avidity, HBeAg-specific TCR-Tg T cells could be activated by exogenous HBeAg, as measured by cytokine production in vitro and T-helper-cell function for anti-HBe antibody production in vitro and in vivo. Furthermore, activated TCR-Tg HBeAg-specific T cells polarized to the Th1 subset were able to elicit liver injury when transferred into HBeAg or HBcAg-Tg recipients. Therefore, HBeAg-specific CD4(+) T cells that can survive deletion or anergy in the presence of circulating HBeAg nonetheless are capable of being activated and of mediating liver injury in vivo. The 11/4-12 TCR-Tg lineage may serve as a monoclonal model for the HBe/HBcAg-specific CD4(+) T-cell repertoire present in chronically infected HBV patients.
Layered double hydroxide nanoparticles in gene and drug delivery (2009)

Layered double hydroxides (LDHs) have been known for many decades as catalyst and ceramic precursors, traps for anionic pollutants, catalysts and additives for polymers, but their successful synthesis on the nanometer scale a few years ago opened up a whole new field for their application in nanomedicine. The delivery of drugs and other therapeutic/bioactive molecules (e.g., peptides, proteins, nucleic acids) to mammalian cells is an area of research that is of tremendous importance to medicine and provides manifold applications for any new developments in the area of nanotechnology. Among the many different nanoparticles that have been shown to facilitate gene and/or drug delivery, LDH nanoparticles have attracted particular attention owing to their many desirable properties. This review aims to report recent progress in gene and drug delivery using LDH nanoparticles. It summarizes the advantages and disadvantages of using LDH nanoparticles as carriers for nucleic acids and drugs against the general background of bottlenecks that are encountered by cellular delivery systems. It describes further the models that have been proposed for the internalization of LDH nanoparticles into cells so far and discusses the intracellular fate of the particles and their cargo. The authors offer some remarks on how this field of research will progress in the near future and which challenges need to be overcome before LDH nanoparticles can be used in a clinical setting.
Expression of Tenascin-C in Bones Responding to Mechanical Load (1997)

A number of early biochemical responses of bone cells to mechanical loading have been identified, but the full sequence of events from the sensing of strain to the formation of new bone is poorly characterized. Extracellular matrix proteins can modulate cell behavior and would be ideal molecules to amplify the early response to loading. The extracellular matrix protein, tenascin-C, supports differentiation of cultured osteoblast-like cells. The current study was carried out to investigate whether expression patterns of tenascin-C in loaded bones support a role for this protein as a mediator of the osteoregulatory response to loading. Tenascin-C expression was investigated by Northern blot analysis in rat ulnae subjected to an established noninvasive loading regimen engendering physiological strain levels. RNA extracted from loaded compared with contralateral control bones 6 h after loading showed a significant increase in tenascin-C transcript expression. The presence of tenascin-C was investigated by immunohistochemistry in bones of animals killed 3, 5, or 15 days after the initiation of daily loading. In animals killed at 3 or 5 days, periosteal surfaces undergoing load-induced reversal from resorption to formation showed enhanced tenascin-C staining. In animals killed at 15 days, the bone formed in response to loading was clearly demarcated from old bone by strong tenascin-C staining of reversal lines. Within this new bone, tenascin-C staining was seen in the lacunae of older but not more recently embedded osteocytes. The results presented here indicate that tenascin-C expression by bone cells is enhanced in the early osteogenic response to loading. This may indicate that tenascin-C acts as a mediator of the mechanically adaptive response.
FTIR spectroscopic studies of the conformation and amide hydrogen exchange of a peptide model of the hydrophobic transmembrane .alpha.-helixes of membrane proteins (1992)

The conformation and amide hydrogen exchangeability of the hydrophobic peptide Lys2-Gly-Leu24-Lys2-Ala-amide were studied by Fourier transform infrared spectroscopy. In these studies information on the secondary structure of the peptide was obtained from an examination of the contours of both the amide I and amide II absorption bands. The conformationally sensitive amide I and amide II regions of the infrared spectra suggest that the peptide is predominantly alpha-helical and that it contains some non-alpha-helical structures which are probably in an extended conformation. Studies of the exchangeability of the amide protons of the peptide indicate that there are two populations of amide protons which differ markedly with respect to their exchangeability with the bulk solvent phase, whether the peptide is dissolved in methanol or dispersed in hydrated lipid bilayers. One population of amide protons is very readily exchangeable, and our data suggest that it arises primarily but not exclusively from the extended regions of the peptide. The other population exchanges very slowly with the bulk solvent and appears to originate entirely from the alpha-helical domain of the peptide. This latter population is virtually unexchangeable when the peptide is dispersed in hydrated phosphatidylcholine bilayers but can be largely exchanged when the peptide is solubilized with methanol. We suggest that this slowly exchanging population of amide protons arises from the central part of the hydrophobic polyleucine core which forms a very stable alpha-helix that would be deeply buried in the hydrophobic domain of hydrated lipid bilayers.(ABSTRACT TRUNCATED AT 250 WORDS)
Maintenance Management: Facing Up to the Need for Revolution (1989)

The visible morale problems within maintenance areas of activity are identified and directly linked to the relatively low level of maintenance leadership. These problems are overlaid with the wider issues of declining performance by Australian industry in general and extended to the newer organisations likely to develop to reverse this trend. The challenges and demands on the maintenance leader in such organisations are identified offering essential directions for maintenance management revolution.
Homocysteine and Cardiovascular Disease (1998)

An elevated level of total homocysteine (tHcy) in blood, denoted hyperhomocysteinemia, is emerging as a prevalent and strong risk factor for atherosclerotic vascular disease in the coronary, cerebral, and peripheral vessels, and for arterial and venous thromboembolism. The basis for these conclusions is data from about 80 clinical and epidemiological studies including more than 10,000 patients. Elevated tHcy confers a graded risk with no threshold, is independent of but may enhance the effect of the conventional risk factors, and seems to be a particularly strong predictor of cardiovascular mortality. Hyperhomocysteinemia is attributed to commonly occurring genetic and acquired factors including deficiencies of folate and vitamin B12. Supplementation with B-vitamins, in particular with folic acid, is an efficient, safe, and inexpensive means to reduce an elevated tHcy level. Studies are now in progress to establish whether such therapy will reduce cardiovascular risk.
VAV1: A new target in pancreatic cancer? (2005)

Pancreatic ductal adenocarcinoma (PDA) is arguably the most lethal malignancy in the United States. Despite the identification of many molecular alterations in PDA, this information has not translated into effective therapeutic strategies to date. A recent report in Cancer Cell (Fernandez-Zapico et al, Cancer Cell 2005, 7:39-49) reveals an unexpected role for the hematopoietic-specific RhoGEF VAV1 in pancreatic tumorigenesis, where ectopic expression of VAV1 as a result of promoter demethylation was identified in the majority of established cell lines and PDA tissue samples. Importantly, VAV1 expression was functionally required for optimal proliferation, transformation and survival of pancreatic cancer cell lines. This study provides the first evidence of VAV1 promoter demethylation as an event in cancer progression, suggesting that aberrant signaling pathways driven by VAV1 are potential therapeutic targets in PDA.
Solution of stellarator boundary value problems with external currents (1987)

Neumann boundary value problems are solved for stellarator fields generated by external currents. The method can be applied to the construction of external coil configurations of stellarators and to studies of the properties of vacuum fields. A computer code, NESCOIL, has been developed and applied to the Helias and ATF stellarator configurations.
Rethinking Reality: A Layered Model of Reality for Immersive Systems (2018)

We introduce the Environment-Augmentation framework and explore how this framework can inform the design of extended reality (i.e., “immersive”) systems and experiences.
Prediction of Naphthalene Bioaccumulation Using an Adipocyte Cell Line Model (2002)

A long-term goal of this research is to develop an in vitro model to study the metabolism, distribution, and fate of chemicals or pharmaceuticals in animals and humans. An important component of such a system is an in vitro model to study bioaccumulation of specific chemicals in adipose tissue. Due to the difficulties in maintaining primary adipocytes in culture and conducting reproducible experiments, transformed adipocyte cell lines have been used as an alternative. In this paper, several rodent preadipocyte cell lines (3T3-L1, 3T3-F442A, and TA1 cells) that differentiate into adipocytes when exposed to the appropriate stimuli are tested as an investigative tool to study naphthalene accumulation. The in vitro model is tested by comparison of its performance to that of primary adipocytes. All the experimental evidence supports the hypothesis that naphthalene accumulation is primarily dependent on the level of intracellular lipid. Furthermore, the level of naphthalene bioaccumulation is linearly correlated with the amount of triglyceride content with the slope of 37.7 +/- 0.5 microg of naphthalene/(mg of triglyceride). Indomethacin/dexamethasone/insulin are shown to be more effective in promoting preadipocyte differentiation than methylisobutylxanthine/dexamethasone/insulin. Additionally, external factors, such as the presence of albumin and serum in the medium, affect the cellular naphthalene uptake by decreasing the amount of naphthalene transported into fat cells. Among the three cell lines tested, 3T3-L1 adipocytes accumulated the highest intracellular lipid and, hence, yielded the highest level of naphthalene accumulation. Its ability to accumulate naphthalene is comparable to that of primary adipocytes. The 3T3-L1 adipocyte model is appropriate for studying the bioaccumulation of xenobiotics that are aromatic hydrocarbons.
Localization of the mutation in an extended family with Charcot-Marie-Tooth neuropathy (HMSN I). (1989)

Hereditary motor and sensory neuropathy type I (HMSN I) or Charcot-Marie-Tooth (CMT) disease is an autosomal dominant peripheral neuropathy. In some CMT families linkage has been reported with either the Duffy blood group or the APOA2 gene, both located on chromosome 1q. More recently, linkage has been found in six CMT families with two chromosome 17p markers. We extensively analyzed a multi-generation Charcot-Marie-Tooth family by using molecular genetic techniques in order to localize the CMT gene defect. First, we constructed a continuous linkage group of 11 chromosome 1 markers and definitely excluded chromosome 1 as the site of mutation. Second, we analyzed the family for linkage with chromosome 17. The two-point lod scores obtained with D17S58 and D17S71 proved that this Charcot-Marie-Tooth family is linked to chromosome 17. Moreover, multipoint linkage results indicated that the mutation is most likely located on the chromosome 17p arm, distal of D17S71.
Oculogyric crisis: A syndrome of thought disorder and ocular deviation (1987)

In 3 patients who suffered oculogyric crises, mental changes accompanied upward deviation of the eyes. In 1 patient, whom we studied in detail, the mental disturbance consisted of a disorder of attention in which pathological fixation of a thought occurred. During the period of upward eye deviation, all functional types of conjugate eye movements were present in the upper field of gaze, suggesting an imbalance of the vertical gaze-holding mechanism. The eyes could be driven down only by a combined blink and downward saccade. Both the thought disorder and the ocular deviation responded promptly to anticholinergic agents. We propose that the disorders of thought and eye movement in oculogyric crisis are linked by a pharmacological imbalance common to both.
Lack of activity of zidovudine in AIDS-associated Kaposiʼs sarcoma (1989)

The efficacy of zidovudine (AZT) for treatment of patients with Kaposi's sarcoma as the initial manifestation of AIDS was determined in a non-randomized, phase-II clinical trial. Twenty-two patients were treated with zidovudine (300 mg 4 times daily for 8 weeks). In patients with stable disease or showing a response, treatment was continued. After 12 weeks the total daily dose was changed to 1000 mg. Only two of all 22 evaluable patients achieved a response (one complete and one partial response), of only brief duration (2 and 4 months, respectively). There was no such association between antiretroviral activity, increase in CD4+ cells and tumour response, as was reported during treatment with human recombinant interferon alpha (IFN-alpha). These findings do not support the use of zidovudine as a first-line treatment for patients with AIDS-associated Kaposi's sarcoma.
<title>Flexible organic light-emitting devices</title> (2001)

Today organic light emitting diodes (OLEDs) are entering the market lace as a competitive flat panel display technology. Rapidly OLED displays are moving from small passive matrices to full color active matrices built on conventional indium tin oxide coated glass. The work in this paper is focused on developing high resolution full color displays on flexible substrates. Presented here will be new developments in high efficiency OLED displays with the application of this technology to flexible substrates thus allowing a whole new generation of display concepts to be realized.
The neoantigen landscape underlying clinical response to ipilimumab. (2014)

3003 Background: Ipilimumab, an antibody against cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), prolongs overall survival and can produce durable tumor regression in patients with advanced melanoma. Ipilimumab activates cytotoxic T-lymphocytes and enables them to destroy tumor cells. However, the molecular determinants of response to ipilimumab are unknown. Methods: Fresh frozen tumor DNA (and matching blood) from 25 melanoma patients treated with ipilimumab was subjected to whole exome sequencing. Exon capture was performed using the SureSelect Human All Exon 50MB kit (Agilent). Enriched exome libraries were sequenced on the HiSeq 2000 platform (Illumina) to a mean coverage of 103X. Somatic mutations and candidate somatic neoantigens generated from these mutations were identified and characterized. Results: Our cohort included complete responders (CR) and nonresponders (NR). Mutational burden ranged from 1-1121 mutations per tumor. Mutational load was significantly associated with clinical response (p=0.028, CR vs. NR, Fisher’s Exact Test), but alone was not sufficient to predict response. Using genome-wide somatic neoepitope analysis, we defined candidate tumor neoantigens and identified a neoantigen landscape that is specifically present in tumors with complete responses to ipilimumab. These somatic neoepitopes share consensus sequences with experimentally validated antigens from a variety of pathogens. Furthermore, in four of six CR patients, a mutation led to the generation of a consensus amino acid sequence previously identified as necessary for T-cell recognition of melanoma antigen recognized by T-cells (MART-1). Conclusions: Somatic mutations and concomitant generation of neoepitopes in melanoma tumors confers enhanced antigenicity and response to the immune checkpoint modulator ipilimumab. Our study defines the neoantigen landscape in responders to ipilimumab, provides a rationale for examining the exomes of patients for whom ipilimumab is being considered, and builds a foundation for understanding the molecular determinants of response to cancer immunotherapy.
How to assess intestinal viability during surgery: A review of techniques (2011)

Objective and quantitative intraoperative methods of bowel viability assessment are essential in gastrointestinal surgery. Exact determination of the borderline of the viable bowel with the help of an objective test could result in a decrease of postoperative ischemic complications. An accurate, reproducible and cost effective method is desirable in every operating theater dealing with abdominal operations. Numerous techniques assessing various parameters of intestinal viability are described by the studies. However, there is no consensus about their clinical use. To evaluate the available methods, a systematic search of the English literature was performed. Virtues and drawbacks of the techniques and possibilities of clinical application are reviewed. Valuable parameters related to postoperative intestinal anastomotic or stoma complications are analyzed. Important issues in the measurement and interpretation of bowel viability are discussed. To date, only a few methods are applicable in surgical practice. Further studies are needed to determine the limiting values of intestinal tissue oxygenation and flow indicative of ischemic complications and to standardize the methods.
Application of Gutzwiller's Variational Method to the Metal-Insulator Transition (1970)

It is shown that the approximate variational calculation of Gutzwiller predicts a metal-insulator transition as the intra-atomic Coulomb interaction is increased for the case of one electron per atom. The susceptibility and effective mass are calculated in the metallic phase and are found to be enhanced by a common factor which diverges at the critical value of the interaction.