gebhart/patrepeval huggingface dataset:
Central Nervous System Depressants. V. Polyhydroxy and Methoxyphenyl Ketones, Carbinols, and Derivatives (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCentral Nervous System Depressants. V. Polyhydroxy and Methoxyphenyl Ketones, Carbinols, and DerivativesRobert Bruce Moffett, A. R. Hanze, and Patrick H. SeayCite this: J. Med. Chem. 1964, 7, 2, 178–186Publication Date (Print):March 1, 1964Publication History Published online1 May 2002Published inissue 1 March 1964https://pubs.acs.org/doi/10.1021/jm00332a013https://doi.org/10.1021/jm00332a013research-articleACS PublicationsRequest reuse permissionsArticle Views254Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
RST 3D: A Comprehensive Gesture Set for Multitouch 3D Navigation (2018)

We present a comprehensive multitouch input mapping for 3D navigation of multiscale 3D models. In contrast to prior work, our technique offers explicit control over 3D rotation, 3D translation, and uniform scaling with manipulative gestures that do not require graphical widgets. Our proposed technique is consistent with the established RST mapping (rotation, scaling, translation) for 2D mul-titouch input and follows suggestions from prior work on multitouch 3D interaction. Our implementation includes a rendering technique that can reduce perceptual conflicts of 3D touch input on stereoscopic displays. We also report on two user studies that informed the suggested interaction design and confirmed its usability.
Microwave Plasma CVD of Oxide Films Relating to High-T<sub>c</sub>Bi-Sr-Ca-Cu-O Superconductor (1990)

Abstract As a low temperature preparation method of Bi, Sr, Ca, and Cu oxide and fluoride films, microwave plasma of Ar and O2 gases was applied to decompose Bi(C6H5)3 and metal β-diketone complexes. As-deposited crystalline Bi2O3, CuO, SrF2, and CaF2 films were obtained at a substrate temperature of 400°C and below. The film thickness was nearly proportional to the deposition time for each film. These Bi2O3, SrF2, CuO, and CaF2 crystalline films designed to have a 2000A thickness each were stacked and annealed at 850°C for 30min to show a superconductivity with TC onset at 65K.
Novel trust consensus protocol and blockchain-based trust evaluation system for M2M application services (2019)

The increasing number of intelligent Machine-to-Machine Communication (M2M) devices in the end-user domain provide good resources for creating and sharing M2M application services. Therefore, transferring the role of a traditional centralized service provider to decentralized peers (end-users) acting as service providers is very promising. However, the future of decentralized M2M application services which are independently provided or consumed by several end-users in the M2M community depends on trust. Untrustworthy peers trying to deploy malfunctioning services for others mitigate the benefits of decentralized systems. Nowadays, the concept of distributed ledger and blockchain has an increased popularity regarding trustless computing among communities operating without centralized authorities. This research publication provides a comprehensive analysis and approach merging the concepts of M2M application services, trust and distributed ledger technologies. Moreover, this publication presents an optimized Trust Evaluation System which is used to ensure trustworthiness among peers in a M2M community. To improve the Trust Evaluation System the integration of blockchain for data storage is introduced. Additionally, blockchain technology is used to extend the existing trust model of the Trust Evaluation System to enable tamper-proof data and detection of untrustworthy peers. This publication reviews several existing approaches in the academic and industry sector to highlight the limitations of the blockchain regarding the consensus and proposes a novel Trust Consensus Protocol. This research publication also provides a practical evaluation of the proposed protocol.
The Effect of Drawing and Annealing Conditions on the Structure and Properties of Bacterial Poly(3-hydroxybutyrate-co-3 hydroxyvalerate) Fibers (1997)

Abstract The effect of drawing and annealing on structure development and resulting properties of bacterial poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (P(3HB-co-3HV)) fibers have been investigated. Melt spun and subsequently drawn and annealed fibers were characterized by wide-angle and small-angle X-ray scattering techniques. WAXS studies revealed that these fibers possess bimodal chain orientation with two populations of crystals: in the first population the chain axes are oriented primarily along the fiber axis and in the second population these chain axes are oriented in the transverse direction to the fiber axis. In the latter crystals, a- and b-axes are randomly distributed around their c-axes. At the annealing temperature of 100° C, the relative population of the crystals oriented normal to the fiber axis was found to be large and their proportion decreases with the increase of annealing temperature. SAXS patterns were found to accompany the changes observed in the WAXS patterns. The tensile strength of these fibers improved by the increase of the proportion of the transversely oriented chains.
Genotypic Diversity among <i>Brevibacillus laterosporus</i> Strains (1999)

In comparison with other entomopathogenic Bacillus species, the genome of Brevibacillus laterosporus is poorly characterized. The aim of this study was to examine genetic variability in B. laterosporus by using a range of typing methodologies. Strains of B. laterosporus were examined for variation in 13 chromosomal genes encoding enzymes by multilocus enzyme electrophoresis. Optimal conditions of pulsed-field gel electrophoresis and randomly amplified polymorphic DNA were established that allowed analysis of the genome of B. laterosporus. None of these techniques allowed the identification of a convenient molecular marker for entomopathogenic strains, although one specific primer amplified only DNA from almost all mosquitocidal strains.
A Genome Scan for Quantitative Trait Loci Affecting Milk Production in Norwegian Dairy Cattle (2002)

An autosomal genome scan for quantitative trait loci (QTL) affecting milk production traits was carried out on the Norwegian Dairy Cattle population. Six half-sibling families with a total of 285 sons organized according to a granddaughter design were analyzed by a multiple marker regression method. Suggestive QTL for one or several of the five milk traits (milk yield, protein percentage, protein yield, fat percentage and fat yield) were detected on chromosomes 3, 5, 6, 11, 13, 18 and 20. Among these results, the findings on chromosomes 3, 6, and 20 are highly supported by literature. The most convincing result was found close to marker FBN9 on chromosome 6, where a QTL was detected with alleles that cause a marked reduction in both protein and fat percentages and an increase in milk yield. The results for fat and protein percentage were highly significant even after accounting for multiple testing across the genome. Using bootstrapping, a 95% confidence interval for the position of the QTL for the percentage traits on chromosome 6 was estimated to 16 cM.
Furans in synthesis. 5. Furan-terminated cationic cyclizations in the preparation of fused, spirocyclic and bridged ring systems. An application to the synthesis of nakafuran 9 (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFurans in synthesis. 5. Furan-terminated cationic cyclizations in the preparation of fused, spirocyclic and bridged ring systems. An application to the synthesis of nakafuran 9Steven P. Tanis and Paul M. HerrintonCite this: J. Org. Chem. 1985, 50, 21, 3988–3996Publication Date (Print):October 1, 1985Publication History Published online1 May 2002Published inissue 1 October 1985https://pubs.acs.org/doi/10.1021/jo00221a008https://doi.org/10.1021/jo00221a008research-articleACS PublicationsRequest reuse permissionsArticle Views991Altmetric-Citations37LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Structure-Based Design of Head-Only Fusion Glycoprotein Immunogens for Respiratory Syncytial Virus (2016)

Respiratory syncytial virus (RSV) is a significant cause of severe respiratory illness worldwide, particularly in infants, young children, and the elderly. Although no licensed vaccine is currently available, an engineered version of the metastable RSV fusion (F) surface glycoprotein-stabilized in the pre-fusion (pre-F) conformation by "DS-Cav1" mutations-elicits high titer RSV-neutralizing responses. Moreover, pre-F-specific antibodies, often against the neutralization-sensitive antigenic site Ø in the membrane-distal head region of trimeric F glycoprotein, comprise a substantial portion of the human response to natural RSV infection. To focus the vaccine-elicited response to antigenic site Ø, we designed a series of RSV F immunogens that comprised the membrane-distal head of the F glycoprotein in its pre-F conformation. These "head-only" immunogens formed monomers, dimers, and trimers. Antigenic analysis revealed that a majority of the 70 engineered head-only immunogens displayed reactivity to site Ø-targeting antibodies, which was similar to that of the parent RSV F DS-Cav1 trimers, often with increased thermostability. We evaluated four of these head-only immunogens in detail, probing their recognition by antibodies, their physical stability, structure, and immunogenicity. When tested in naïve mice, a head-only trimer, half the size of the parent RSV F trimer, induced RSV titers, which were statistically comparable to those induced by DS-Cav1. When used to boost DS-Cav1-primed mice, two head-only RSV F immunogens, a dimer and a trimer, boosted RSV-neutralizing titers to levels that were comparable to those boosted by DS-Cav1, although with higher site Ø-directed responses. Our results provide proof-of-concept for the ability of the smaller head-only RSV F immunogens to focus the vaccine-elicited response to antigenic site Ø. Decent primary immunogenicity, enhanced physical stability, potential ease of manufacture, and potent immunogenicity upon boosting suggest these head-only RSV F immunogens, engineered to retain the pre-fusion conformation, may have advantages as candidate RSV vaccines.
System Architecture for Cooperative Vehicle-Pedestrian Safety Applications Using DSRC Communication (2015)

<div class="section abstract"><div class="htmlview paragraph">Pedestrians account for a significant ratio of traffic fatalities; as a result, research on methods of reducing vehicle-pedestrian crashes is of importance. In this paper, we describe a system architecture that allows the use of vehicle-to-pedestrian (V2P) communication as a means of generating situational awareness and eventually predicting hazards and warning drivers and pedestrians. In contrast, vehicle-to-vehicle (V2V) and vehicle-to-infrastructure (V2I) communication for safety applications, V2P has not received much attention. One major reason for this lack of attention had been the unavailability of communication mechanisms between pedestrians and vehicles. Recent advances in enabling Wi-Fi and dedicated short range communication (DSRC) based communication using smart-phones is changing this picture. As a result, V2P communication can be considered as a possible solution. In this paper, we first investigate the feasibility of V2P crash avoidance applications, considering the fact that pedestrian movement dynamics, response times, and crash scenarios are different from V2V scenarios. We then propose an architecture for V2P crash avoidance systems. The architecture has vehicle side and pedestrian side applications. Each of them communicates its current state information such as position and time to the other device. Using this information, crash threats can be predicted and an advisory or imminent collision warning will be generated. Finally, we demonstrate and evaluate a developed V2P crash avoidance system based on this architecture.</div></div>
A microstrip patch antenna with coplanar feed line (1991)

An experimental investigation of a microstrip patch antenna with a coplanar feed line is presented. The coupling from the coplanar line to the patch is accomplished via a slot in the ground plane to which the coplanar line is connected either inductively or capacitively. The input return loss can easily be adjusted via the slot length. Additional frequency tuning is possible by switching between inductive and capacitive coupling.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A GOG 210 aCGH study of gain at 1q23 in endometrioid endometrial cancer in the context of racial disparity and outcome (2010)

The goal of this study was to identify recurrent regions of genomic gain or loss in endometrial cancer of the endometrioid type in the context of racial disparities in mortality for this disease. Array comparative genomic hybridization (aCGH) analysis was performed on 80 frozen primary tumors from the Gynecologic Oncology Group (GOG)-210 bank using the RPCI 19K BAC arrays. The 80 patients included 20 African American (AA) Stage I, 20 White (W) Stage I, 20 African American (AA) Stage IIIC/IV, and 20 White (W) Stage IIIC/IV. A separate subset of 220 endometrial cancers with outcome data was used for validation. A 1.6-Mbp region of gain at 1q23 was identified by aCGH in all AA patients and high grade W patients, but not W low grade patients. In the validation arm of 220 patients copy number gain at this region was validated using FISH and locus specific BACs. The number of AA patients in the validation arm was too small to confirm the aCGH association with racial disparity. Kaplan-Meier curves for survival showed a significant difference for gain at 1q23 versus no gain (log rank P = 0.0014). When subdivided into various groups of risk by stage and grade the survival curves showed a decreased survival for high grade and/or stage tumors, but not for low grade and/or stage endometrioid tumors. Univariate analyses for gain at 1q23 showed a significant association (P = 0.009) with survival. Multivariate analysis for gain at 1q23 did not show a significant association with survival (P = 0.14).
Could the Pharmacological Differences Observed Between Angiotensin II Antagonists and Inhibitors of Angiotensin Converting Enzyme be Clinically Beneficial? (1992)

Abstract: Over the past several years, angiotensin I converting enzyme (ACE) inhibitors, compounds that block the formation of angiotensin II (ANG II), have become widely used in the treatment of cardiovascular disease. Recently, a new class of orally active, non‐peptide inhibitors of the renin‐angiotensin system, the ANG II receptor antagonists have also become available. Since both classes of compounds block the renin‐angiotensin system, although at different sites, it remains to be determined whether blockade of ANG II receptors will have any specific advantage over inhibition of ACE. The following review assesses the actions of ANG II antagonists and suggests ways in which blockade of ANG II receptors may differ both pharmacologically and clinically from inhibition of ACE.
Vascularized Autografts for Reconstruction of Skeletal Defects Following Lower Extremity Trauma (1989)

Over the last 15 years, vascularized bone grafts have proved to be a valuable method of reconstructing skeletal defects in the extremities. Successful skeletal reconstruction has been reported following tumor resection, select traumatic skeletal defects, congenital pseudarthrosis, and both infected and uninfected skeletal nonunions unresponsive to conventional methodology. Incorporation of the graft into the recipient is not as dependent on an uninfected well-vascularized host as a conventional avascular autogenous graft is. Vascularized autografts are also capable of achieving union across large skeletal defects with fewer stress fractures than when avascular autografts are used to span a defect greater than 6 cm. With patency of the vascular anastomoses and union at both ends of the graft, hypertrophy of the segmental graft is not unusual. The overall success rate of ultimate bony union is approximately 80% and is mostly dependent on the recipient location. As discussed in this article, vascularized autografts are a salvage procedure to be used in reconstructing extremities in which conventional reconstructive techniques have failed or are not applicable.
Efficient Web form entry on PDAs (2001)

We propose a design for displaying and manipulating HTML forms on small PDA screens. The form input widgets are not shown until the user is ready to fill them in. At that point, only one widget is shown at a time. The form is summarized on the screen by displaying just the text labels that prompt the user for each widget's information. The challenge of this design is to automatically find the match between each text label in a form, and the input widget for which it is the prompt. We developed eight algorithms for performing such label/widget matches. Some of the algorithms are based on n-gram comparisons, while others are based on common form layout conventions. We applied a combination of these algorithms to 100 simple HTML forms with an average of four input fields per form. These experiments achieved a 95% matching accuracy. We developed a scheme that combines all algorithms into a matching system. This system did well even on complex forms, achieving 80% accuracy in our experiments involving 330 input fields spread over 48 complex forms.
High-speed multiplexers: a 50 Gb/s 4:1 MUX in InP HBT technology (2003)

We have implemented a monolithic electronic 50 Gb/s 4:1 MUX core in an InP-based HBT technology. This rate is the fastest achieved in a monolithic 4:1 MUX to our knowledge, and is currently limited by the speed limitations of our pattern generation equipment. Our 2:1 MUX is too fast for characterization at present, but we present evidence that the speed of the 2:1 MUX is at least 60 Gb/s.
The ETS Transcription Factor Spi-B Is Required for Human Plasmacytoid Dendritic Cell Development (2004)

A number of transcription factors that act as molecular switches for hematopoietic lineage decisions have been identified. We recently described the ETS transcription factor Spi-B to be exclusively expressed in plasmacytoid dendritic cells (pDCs), but not in myeloid DCs. To assess whether Spi-B is required for pDC development we used an RNA interference knock down approach to specifically silence Spi-B protein synthesis in CD34(+) precursor cells. We observed that a knock down of Spi-B mRNA strongly inhibited the ability of CD34(+) precursor cells to develop into pDCs in both in vitro assays as well as in vivo upon injection into recombination activating gene 2(-/-) gamma common(-/-) mice. The observed effects were restricted to the pDC lineage as the differentiation of pro-B cells and CD14(+) myeloid cells was not inhibited but slightly elevated by Spi-B knock down. Knock down of the related ETS factor PU.1 also inhibited in vitro development of CD34(+) cells into pDCs. However, in contrast to Spi-B, PU.1 knock down inhibited B cell and myeloid cell development as well. These results identify Spi-B as a key regulator of human pDC development.
A Practical Guide to Steam Turbine Technology (1995)

Introduction. Turbine Casing and Major Stationary Components. Bearings for Mechanical Drive Turbines. Rotors for Impulse Turbines. Rotors for Reaction Turbines. Turbine Blade Design Overview. Turbine Auxillaries. Governors and Control Systems. Couplings and Coupling Considerations. Rotor Dynamics Technology. Campbell, Goodman, and SAFE Diagrams for Steam Turbine Blades. Reaction vs. Impulse Type Steam Turbines. Transmission Elements for High-Speed Turbomachinery. Shortcut Graphical Methods of Turbine Selection. Elliott Shortcut Selection Method for Multivalve, Multistage Steam Turbines.
The <i>spoIIE</i> Locus Is Involved in the Spo0A-Dependent Switch in the Location of FtsZ Rings in <i>Bacillus subtilis</i> (1998)

A switch in the location of FtsZ ring structures from medial to polar is one of the earliest morphological indicators of sporulation in Bacillus subtilis. This switch can be artificially caused during vegetative growth by induction of an active form, Sad67, of the transcription regulator, Spo0A (P. A. Levin and R. Losick, Genes Dev. 10:478-488, 1996). We have used immunofluorescence microscopy to show that the switch in FtsZ ring location during vegetative growth caused by Sad67 induction is blocked by a spoIIE deletion mutation. The spoIIE mutation also impaired polar FtsZ ring formation during sporulation. These results suggest that SpoIIE mediates the Spo0A-directed formation of polar FtsZ rings.
Induced Crystallization of Perovskites by a Perylene Underlayer for High-Performance Solar Cells (2016)

PSS) and CH3NH3PbIxCl3-x. In addition, perylene and perovskites form a fully crystalline heterojunction, which is beneficial for minimizing the defect and trap densities. Due to these merits, a maximum power conversion efficiency of 17.06% with improved cell stability is achieved. The finding in this work provides a simple route to control perovskite crystallizaition and to optimize the interfaces in PHJ PSCs simultaneously.