gebhart/patrepeval huggingface dataset:
Development, Integration and Qualification of a Measurement System for Accurate and Fast Placements of Flipchips (2012)

A positioning system has been developed that places dies quickly and with high accuracy on a rigid substrate. The increased accuracy makes it possible to stack dies, or use dies with an ultra fine pitch, while not sacrificing speed. A single camera system determines the position of the die on the bondhead, as well as the position of the substrate. As a result, the effect of thermal drift is minimized. In order to decrease the cycle time, the camera system is mounted on the bondhead, so that the die position can be measured while moving. This concept has been successfully integrated and tested on an existing component mounter machine. The resulting accuracy has been increased from 10 to 3 μm (3σ), while the placement cycle time can be reduced by 20 %.
Associative broadcast and the communication semantics of naming in concurrent systems (1993)

Much of the complexity of concurrent program design lies in the specification of patterns of communication: flows of information among objects (e.g. processes) expressed as functions of the global computation state. Underlying the communication mechanisms of every concurrent system is a naming system, which is used to specify the objects participating in each communication. We call those characteristics of naming systems that determine the patterns of communication that can be specified the communication semantics of naming systems. A more expressive naming system allows communication to be specified at a higher level of abstraction. The available communication abstractions are significant in the choice of an algorithm, in which specific patterns of communication are manifest, to solve a particular problem. Thus the choice or design of a naming system often significantly affects the design of concurrent programs. Yet naming systems have not been widely studied as independent components of concurrent systems. This has led to empirical design and inappropriate choices of naming systems, which hinder the specification of complex patterns of communication and constrain algorithm design, yielding awkward programs and inefficient executions. To simplify the use of naming systems in specifying communication, and to make more precise our understanding of their communication semantics, we adopt a twofold approach: The development of a formal taxonomy of naming systems, and the design of a specific naming system and communication primitive, called Associative Broadcast, that enable straightforward specification of complex communication patterns. The taxonomy defines a set of orthogonal properties that characterize the ability of naming systems to express fundamental patterns of communication. Naming systems are classified and ranked in a partially ordered hierarchy according to their properties. The hierarchy allows systematic comparison of naming systems, and selection of naming systems for the solution of problems requiring specific properties. Associative Broadcast resides at the top of the hierarchy, and allows the specification of a dynamic, descriptively named target set of objects as the destination of a message by defining names to be propositional expressions over sets of object attributes, and by using delayed resolution. We apply Associative Broadcast to obtain algorithms with desirable symmetry, robustness, concurrency, and efficiency properties for problems in the areas of distributed constraint reduction, database consistency in the presence of network partition failures, and virtual time synchronization.
Reflection and Transmission of Sound Waves by a Moving Fluid Laver (1967)

The reflection and transmission of sound waves by a moving fluid layer are investigated theoretically and the reflection and transmission coefficients are determined. Numerical computations for the reflection and transmission coefficients as a function of the velocity of the moving medium are also carried out. It is found that the reflection and transmission coefficients are quite sensitive to the variation of the angle of incidence even if the layer is moving slowly. This fact suggests the possiblity of obtaining the speed of the moving fluid layer by measuring the reflection or transmission coefficient as a function of the angle of incidence.
Dissecting the Dualistic Effects of Transforming Growth Factor (TGF)-β on Fibroproliferation and Extracellular Matrix Production in Primary Human Lung Fibroblasts - The Role of p38δ MAP Kinase (2009)

Rationale: Inflammation, increased fibroblast proliferation, and increased deposition of extracellular matrix (ECM) are hallmarks of early lung fibrosis and asthma. Transforming growth factor-(TGF-) has been suggested as a key regulator of lung tissue homeostasis with several and often opposite effects on fibroblast proliferation and ECM production. In human and animal model systems, it has been shown that TGF-induced several signaling cascades including Smads, p38 mitogen-activated protein (MAP) kinases, and extracellular signal-regulated kinases 1/2 (ERK). Information on how TGF-regulates and controls normal primary lung fibroproliferation and ECM production is not present.
Preclinical and early clinical development of GNbAC1, a humanized IgG4 monoclonal antibody targeting endogenous retroviral MSRV-Env protein (2014)

Monoclonal antibodies (mAbs) play an increasing important role in the therapeutic armamentarium against multiple sclerosis (MS), an inflammatory and degenerative disorder of the central nervous system. Most of the mAbs currently developed for MS are immunomodulators blocking the inflammatory immune process. In contrast with mAbs targeting immune function, GNbAC1, a humanized IgG4 mAb, targets the multiple sclerosis associated retrovirus envelope (MSRV-Env) protein, an upstream factor in the pathophysiology of MS. MSRV-Env protein is of endogenous retroviral origin, expressed in MS brain lesions, and it is pro-inflammatory and toxic to the remyelination process, by preventing the differentiation of oligodendrocyte precursor cells. We present the preclinical and early clinical development results of GNbAC1. The specificity of GNbAC1 for its endogenous retroviral target is described. Efficacy of different mAb versions of GNbAC1 were assessed in MSRV-Env induced experimental allergic encephalitis (EAE), an animal model of MS. Because the target MSRV-Env is not expressed in animals, no relevant animal model exists for a proper in vivo toxicological program. An off-target 2-week toxicity study in mice was thus performed, and it showed an absence of safety risk. Additional in vitro analyses showed an absence of complement or antibody-dependent cytotoxicity as well as a low level of cross-reactivity to human tissues. The first-in-man clinical study in 33 healthy subjects and a long-term clinical study in 10 MS patients showed that GNbAC1 is well tolerated in humans without induction of immunogenicity and that it induces a pharmacodynamic response on MSRV biomarkers. These initial results suggest that the mAb GNbAC1 could be a safe long-term treatment for patients with MS with a unique therapeutic mechanism of action.
Site et sable (1988)

Commande du Syndicat d'agglomeration nouvelle d'Evry. - Musique pour la sculpture de Guy Guiraud
Identification and initial characterization of translational initiation factor 2 from bovine mitochondria. (1990)

The bovine liver mitochondrial factor that promotes the binding of fMet-tRNA to mitochondrial ribosomes, initiation factor 2 (IF-2mt), has been identified in the postribosomal supernatant fraction of isolated liver mitochondria. This factor has been purified approximately 5,000-fold and present preparations are estimated to be about 10% pure. IF-2mt has an apparent molecular weight of about 140,000 as determined by gel filtration chromatography. IF-2mt is active in stimulating fMet-tRNA binding to Escherichia coli ribosomes but E. coli IF-2 is not active in promoting initiator tRNA binding to animal mitochondrial ribosomes. The IF-2mt-mediated binding of fMet-tRNAi(Met) to mitochondrial ribosomes is dependent on the presence of a message such as poly(A,U,G) and on GTP. Nonhydrolyzable analogs of GTP are 2-3-fold less effective in promoting initiation complex formation on mitochondrial ribosomes than is GTP suggesting that IF-2mt is capable of recycling to some extent under the current assay conditions.
The use of a new suture material (Polydioxanone) in the biliary tract. (1983)

The use of a new synthetic absorbable suture material, polydioxanone, has been assessed over a period in excess of three years in 63 patients undergoing surgical procedures on the biliary tract. The material, which was used exclusively for all ligatures and sutures, has greater pliability and strength than other absorbable materials and was found to be highly satisfactory. No suture-related complications were identified and the handling properties of the material were excellent. This material can be recommended for use in the biliary tract where it is desirable to use a reliable absorbable suture which evokes minimal tissue reaction.
Theory of electron, phonon and spin transport in nanoscale quantum devices (2018)

At the level of fundamental science, it was recently demonstrated that molecular wires can mediate long-range phase-coherent tunnelling with remarkably low attenuation over a few nanometre even at room temperature. Furthermore, a large mean free path has been observed in graphene and other graphene-like two-dimensional materials. These create the possibility of using quantum and phonon interference to engineer electron and phonon transport through nanoscale junctions for a wide range of applications such as molecular switches, sensors, piezoelectricity, thermoelectricity and thermal management. To understand transport properties of such devices, it is crucial to calculate their electronic and phononic transmission coefficients. The aim of this tutorial article is to outline the basic theoretical concepts and review the state-of-the-art theoretical and mathematical techniques needed to treat electron, phonon and spin transport in nanoscale molecular junctions. This helps not only to explain new phenomenon observed experimentally but also provides a vital design tool to develop novel nanoscale quantum devices.
An Object-Oriented Model for Network Management (1988)

Most networks today lack management tools that support automated identification of faults and bottlenecks and support effective recovery procedures. The NetMATE project, discussed in this paper, addresses the issue related to distributed network management of large, heterogeneous networks. NetMATE employs a modular, object-oriented approach to develop extensible management tools and a model for network information. The first prototype of the system confirms the elegance of the design.
Development of Drug Delivery Systems from Vegetal Proteins: Legumin Nanoparticles (1996)

Legumin (storage protein from Pisum sativum L.) nanoparticles of about 250 nm were prepared by means of a pH-coacervation method and chemical cross-linking with glutaraldehyde. This preparative method enabled to avoid the use of organic solvents but only yielded about 27% of protein added as nanoparticles. No significant differences in size, percentage yield, and surface charge were obtained between legumin nanoparticles cross-linked with different glutaraldehyde concentrations. Legumin nanoparticles were quite stable in phosphate-buffered saline (PBS). They follow a zero-order degradation, and by increasing glutaraldehyde concentration, a longer half-life (t50) was obtained. The amount of methylene blue (MB), used as a model of hydrophilic drug, loaded was about 6.2% of the initial dye. Its release from the nanoparticles consisted of a rapid initial phase followed by a slower second period. The rates in this second phase were inversely related to the degree of cross-linking.
Characterisation of IRTKS, a novel IRSp53/MIM family actin regulator with distinct filament bundling properties (2007)

IRSp53 is a scaffold protein that contains an IRSp53/MIM homology domain (IMD) that bundles actin filaments and interacts with the small GTPase Rac. IRSp53 also binds to the small GTPase Cdc42 and to Scar/WAVE and Mena/VASP proteins to regulate the actin cytoskeleton. We have characterised a novel IMD-containing protein, insulin receptor tyrosine kinase substrate (IRTKS), which has widespread tissue distribution, is a substrate for the insulin receptor and binds Rac. Unlike IRSp53, IRTKS does not interact with Cdc42. Expression of IRTKS induces clusters of short actin bundles rather than filopodia-like protrusions. This difference may be attributable to a short carboxyl-terminal (Ct) extension present on IRTKS, which resembles a WASP-homology 2 (WH2) motif. Addition of the Ct extension to IRSp53 causes an apparent shortening of bundles induced by the IMD in vitro, and in cultured cells, suggesting that the Ct extension of IRTKS modulates the organising activity of the IMD. Lastly, we could not detect actin monomer sequestration by the Ct extension of IRTKS as would be expected with a conventional WH2 motif, but it did interact with actin filaments.
Therapeutic effects of STAT3 decoy oligodeoxynucleotide on human lung cancer in xenograft mice (2007)

STAT3 decoy ODN significantly suppressed lung cancer cells in vitro and in vivo, indicating that STAT3 decoy ODN may be a potential therapeutic approach for treatment of lung cancer.
Analysis and Validation of a Real-Time AC Drive Simulator (2004)

This paper presents the analysis and validation of a real-time AC drive simulator. Real-time simulation has been used for over a decade in power systems engineering to test controllers thoroughly, efficiently, and safely. The development and testing of large DC drives could benefit from this type of simulation, but real-time power system simulators have modeling restrictions preventing stable and accurate simulation of isolated drives switching at high frequencies. These restrictions can be overcome by combining in a single model both the power converter and motor models. After discussing the salient issues related to the real-time simulation of DC drives, a prototype real-time simulator for drives is described. Its ability to accurately emulate the behavior of large drives is demonstrated through two case studies. A first case study demonstrates the feasibility of simulating a drive of typical complexity in real-time. The second case study demonstrates how the controller for a PWM VSI fed induction motor, switching at 4 kHz, is designed, implemented in a microcontroller and tested in real-time using a simulated inverter, motor and load. Comparisons against results obtained with another simulation tool, which uses extremely accurate variable-step integration algorithms, demonstrates the validity of our approach.
Learning Control Of Compensative Trunk Motion For Biped Walking Robot Based On ZMP Stability Criterion (2005)

The authors have been using the ZMP (Zero Mo- ment Point) as a criterion to distinguish the stability of walk- ing for a biped walking robot that has a trunk. In this paper, the authors propose a learning control algorithm of the com- pensative trunk motion that makes the actual ZMP get closer to the desired ZMP. The convergency of the algorithm is con- firmed by computer simulation and learning experiments with the biped robot. The change of the convergence rate with the change of the weight coefficient multiplied to the errors be- tween the measured ZMP and the desired ZMP is confirmed by the simulation and the experiments. And also the reasons are discussed.
Studies on Novel Bone Resorption Inhibitors. I. Synthesis and Pharmacological Activites of Aminomethylenebisphosphonate Derivatives. (1993)

A series of aminomethylenebisphosphonate derivatives was synthesized and evaluated for their antiresorptive activities using a parathyroid hormone (PTH)-induced hypercalcemia model in rats (PIH model). Among these compounds, (cycloheptylamino)methylenebis(phosphonic acid) (3j) was finally selected for further investigation, proving 10-fold as potent as pamidronate in the PIH model and an immobilization bone atrophy model in rats (DA model). The structure-activity relationships of this series of bisphosphonates are discussed.
Colorimetric Detection of <i>Staphylococcus aureus</i> Contaminated Solutions without Purification (2016)

Current water quality monitoring methods rely on growth-based measurements to detect fecal indicator bacteria, such as Escherichia coli and enterococci, and Staphylococcus aureus (S. aureus). These growth-based measurements, however, can take days to complete. This is a significant limitation in the evaluation of contaminated food and water sources. Various methods for selective in vitro detection of S. aureus have also been reported; however, these strategies, such as ELISA, agar-diffusion, PCR, or liquid chromatography-tandem mass spectrometry, all require overnight culturing or sophisticated instrumentation. There is a pressing need for a portable, simple diagnostic for S. aureus. Here, we demonstrate that oligonucleotide-functionalized gold nanoparticles (Oligo-AuNPs) can be designed to rapidly and selectively detect S. aureus with a colorimetric readout. We have functionalized a chemically modified 11-mer sequence onto AuNPs and have found that aggregation occurs in the presence of S. aureus supernantants. The particles can be stored as a lyophilized powder and reconstituted at time of use, and this has been tested in biologically relevant samples such as creek and ocean water. This approach requires minimal sample preparation and requires no extraneous instrumentation, leading to a rapid and simple diagnostic read-out that could be used in field tests to monitor food and water sources.
Iterative-deepening-A: an optimal admissible tree search (1985)

A set of expression vectors was constructed which allows the expression of recombinant antigens under the control of Salmonella typhi promoters that are selectively activated after infection of eukaryotic cells. The pUC18Not derivatives contain a promoter downstream of the early transcriptional terminator from phage T7 and followed by a multiple cloning site, whereas the pBluescript II S/K derivatives contain the ribosomal RNA T(1) transcriptional terminator and also the strong translation signals of the Escherichia coli atpE gene. The expression cassettes are flanked by NotI or PacI sites to simplify their subcloning where required. The resulting vectors were validated using the S1 subunit of pertussis toxin as a model antigen and Salmonella typhimurium aroA SL7207 as a carrier. The S1 subunit was efficiently expressed by recombinant Salmonella within Henle 407 cells.
Power control for wireless data (2000)

With cellular phones mass-market consumer items, the next frontier is mobile multimedia communications. This situation raises the question of how to perform power control for information sources other than voice. To explore this issue, we use the concepts and mathematics of microeconomics and game theory. In this context, the quality of service of a telephone call is referred to as the "utility" and the distributed power control problem for a CDMA telephone is a "noncooperative game." The power control algorithm corresponds to a strategy that has a locally optimum operating point referred to as a "Nash equilibrium." The telephone power control algorithm is also "Pareto efficient," in the terminology of game theory. When we apply the same approach to power control in wireless data transmissions, we find that the corresponding strategy, while locally optimum, is not Pareto efficient. Relative to the telephone algorithm, there are other algorithms that produce higher utility for at least one terminal, without decreasing the utility for any other terminal. This article presents one such algorithm. The algorithm includes a price function proportional to transmitter power. When terminals adjust their power levels to maximize the net utility (utility-price), they arrive at lower power levels and higher utility than they achieve when they individually strive to maximize utility.
A long-term study of bone mineral density in patients with phenylketonuria under diet therapy (2011)

In this study the low BMD detected in our patients was both at baseline and follow-up independent of diet restriction. A yearly DEXA would be highly beneficial for early detection and treatment, thus preventing osteoporosis and decreasing the risk of fractures. We also suggest the importance of searching for new emerging therapies such as enzyme substitution or gene therapy as low protein diet compliance was not enough to maintain normal bone mineral density.
Sugar Solution Analgesia: The Effects of Glucose on Expressed Mu Opioid Receptors (2005)

Glucose or sucrose solutions administered orally provide effective analgesia for procedural pain in neonates. Because analgesia with sugar solutions can be decreased by opioid receptor antagonists, we tested the hypothesis that glucose directly activates opioid receptors. Mu opioid receptors (MOR-1) were expressed in Xenopus oocytes, a well recognized expression system, and glucose was tested for possible agonist, antagonist, and modulatory effects on the receptor. In control experiments, 10 nM of Tyr-D-Ala-Gly-Me-Phe-Gly-ol (DAMGO), a synthetic enkephalin and specific mu agonist, activated the MOR-1, whereas 20 mM of glucose had no effect. In addition, glucose had no effect on the activation of the mu receptor by DAMGO. Finally, glucose did not modulate acute receptor desensitization induced by DAMGO. We conclude that glucose does not directly interact with MOR-1 in an in vitro expression system and that the purported interaction between glucose and the opioid system may be an indirect one, involving release of endogenous opioids.
Effect of Extracellular DNA Destruction by DNase I on Characteristics of Forming Biofilms (2010)

Biofilm formation plays a crucial role in the development of different infections. This study was designed to examine the effects of extracellular DNA destruction by DNase I on characteristics of forming bacterial biofilms. We have found that extracellular matrix of biofilms formed in the presence of DNase I contains extracellular DNA fragments of about 30 kb. These data support the idea that cell-free DNA is constantly released to the extracellular matrix of bacterial biofilms. Our results indicate that extracellular DNA plays an important role in the properties of forming biofilms. Biofilms formed in the presence of DNase I (5.0 microg/mL) displayed reduced biofilm biomass, total bacterial biomass, decreased viability of bacteria, and decreased tolerance to antibiotics. The fact that destruction of extracellular DNA in forming biofilms by DNase I leads to the formation of an altered microbial community with decreased tolerance to environmental factors suggests the possibility to change the characteristics of forming biofilms by modifying cell-free DNA.
Russian Detention of Three Ukrainian Naval Vessels (2019)

Case Concerning the Detention of Three Ukrainian Naval Vessels, (Ukrainian v Russian Federation), No. 26, 25 May 2019