gebhart/patrepeval huggingface dataset:
24,25-Dihydroxyvitamin D3. Synthesis and biological activity (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT24,25-Dihydroxyvitamin D3. Synthesis and biological activityHing-Yat Lam, Heinrich K. Schnoes, Hector F. DeLuca, and Tai C. ChenCite this: Biochemistry 1973, 12, 24, 4851–4855Publication Date (Print):November 1, 1973Publication History Published online1 May 2002Published inissue 1 November 1973https://pubs.acs.org/doi/10.1021/bi00748a007https://doi.org/10.1021/bi00748a007research-articleACS PublicationsRequest reuse permissionsArticle Views97Altmetric-Citations49LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Carboxypeptidase M Is Identical to the MAX.1 Antigen and Its Expression Is Associated with Monocyte to Macrophage Differentiation (1995)

The two monoclonal antibodies MAX.1 and MAX.11 recognize cell surface antigens that are almost undetectable on monocytes but highly expressed on differentiated macrophages. Biochemical characterization revealed that both antibodies detect the same 58-64-kDa glycoprotein anchored to the plasma membrane by glycosyl-phosphatidylinositol linkage. We purified the MAX.1/11 antigen by immunoaffinity chromatography using monoclonal antibody MAX.11. The NH2-terminal amino acid sequence was determined and turned out to be identical to the NH2-terminal sequence of the membrane-bound carboxypeptidase M. By precipitation with antibodies MAX.1 and MAX.11, membrane preparations of macrophages and placental microvilli were almost completely depleted of enzyme activity, indicating that the two antibodies indeed recognize carboxypeptidase M. Immunoreactivity of both antibodies correlates with the reported tissue distribution of enzyme activity. Expression of carboxypeptidase M on mRNA level and enzymatic activity markedly increase during in vitro differentiation of monocytes, according to the described increase in MAX.1 and MAX.11 antigen expression. Moreover, in vitro differentiated macrophages show the highest specific activity yet described in any tissue. In addition, carboxypeptidase M expression could be detected in HL-60, U937, and THP-1 myeloid cell lines. Vitamin D3-induced monocytic differentiation resulted in an increased carboxypeptidase M expression in all three cell lines. Further studies are needed to elucidate the functional role of carboxypeptidase M during monocytic differentiation and activation.
君王跨性，陰陽同體：以跨性別戰略閱讀娥蘇拉‧勒瑰恩的《瀚星故事集》 (2011)

This paper proposes a sexually recalcitrant re-reading on Ursula K. Le Guin's science fictional writing, especially the ones which portrays queer body politics and a (seldom explored) transgender nuance vividly implicated in some of her representations such as The Left Hand of Darkness, ”Winter's King”, and several short stories included in The Birthday of the World: And Other Stories. My addresses on these trans-queer embodiments not only aim to unveil and decrypt those difficulty excruciating undertexts (and non-normative queer genders) living within seemingly reticent mythical fables and otherworldly alien topography, I also argue for an epistemological perception that always exists by embedding painfully allegorical inscriptions of these transgender bodies-as-closets in a universe full of gentle disagreements with linear temporality, bi-polar gender paradigm, hierarchical lineage, bondage in name of state, sex, and familial obligation, hetero-normativity and homonormativity.Another paramount issue of extrapolation in this paper is my meta-analysis and theoretical correspondence with several stances in regard to gender, sexuality, queer subjectivity, and other-gendered representations. On the one hand, I argue against established, canonized literary criticism and normative gender/sexual politics from a retrospective point of view which reads these discourses as either hegemonic male sexist imagination or anxious maternal figures trying to correcting misfit marginal personifications. On the other hand, I formulate a fugue-like intertextual correspondence with several insightful sf critical endeavors, transgender discourses, and queer theories.
A computerized identification and data analysis of eyeblink EOG waves. (1994)

本研究の目的は, 自発性瞬目波形を自動認識するコンピュータシステムの開発と, 自発性瞬目波形の諸測度の有用性を評価することである. EOG法では通常, 瞬目に類似した波形を瞬目波形と識別するのは困難である. そこで, 自動的に瞬目波形を認識するためにEOGの微分値を用いたアルゴリズムを提案した. また, このアルゴリズムを使ったシステムの開発を行い, 10人の被験者データを用いてシステムの評価を行った. 自動的に検出された瞬目波形と, 実験中の被験者の眼瞼の動きと記録紙への記録を合成したビデオ画像による比較を行った結果, 2つのデータ間の一致率は72.7%から98.2%と比較的高く, 平均は91.7%であった. 瞬目波形の諸測度を定義し, 10人の被験者の瞬目波形の諸測度を計測した. これらの諸測度間の相関をとったところ, 振幅が瞬目波形の特徴を記述するのに最良の測度であることが示唆された.
Vesti: Energy-Efficient In-Memory Computing Accelerator for Deep Neural Networks (2019)

To enable essential deep learning computation on energy-constrained hardware platforms, including mobile, wearable, and Internet of Things (IoT) devices, a number of digital ASIC designs have presented customized dataflow and enhanced parallelism. However, in conventional digital designs, the biggest bottleneck for energy-efficient deep neural networks (DNNs) has reportedly been the data access and movement. To eliminate the storage access bottleneck, new SRAM macros that support in-memory computing have been recently demonstrated. Several in-SRAM computing works have used the mix of analog and digital circuits to perform XNOR-and-ACcumulate (XAC) operation without row-by-row memory access and can map a subset of DNNs with binary weights and binary activations. In the single array level, large improvement in energy efficiency (e.g., two orders of magnitude improvement) has been reported in computing XAC over digital-only hardware performing the same operation. In this article, by integrating many instances of such in-memory computing SRAM macros with an ensemble of peripheral digital circuits, we architect a new DNN accelerator, titled Vesti. This new accelerator is designed to support configurable multibit activations and large-scale DNNs seamlessly while substantially improving the chip-level energyefficiency with favorable accuracy tradeoff compared to conventional digital ASIC. Vesti also employs double-buffering with two groups of in-memory computing SRAMs, effectively hiding the row-by-row write latencies of in-memory computing SRAMs. The Vesti accelerator is fully designed and laid out in 65-nm CMOS, demonstrating ultralow energy consumption of <; 20 nJ for MNIST classification and <; 40 μJ for CIFAR-10 classification at 1.0-V supply.
[Polymorphism of HLA-DRB1, DQB1 in the Hans of north China] (1999)

OBJECTIVE: To understand polymorphism of HLA-DRB1, DQB1 in the Hans of north China and obtain more comprehensive and accurate data on genetics at DNA level. METHODS: Polymerase chain reaction-sequence specific primers (PCR-SSP) were used to determine HLA-DRB1, DQB1 alleles in 107 unrelated healthy Han individuals of north China. RESULTS: The authors determined 14 DRB1, 9 DQB1 alleles, which included not only the allele frequencies that corresponded to the gene frequencies of DR, DQ loci determined by other 9 cooperating labs but also the allele frequencies of DRB1*15, DRB1*16, DQB1*0301, DQB1*0302, DQB1*0303, DQB1*05, DQB1*0601, DQB1*0602, and DQB1*0604 that other serology labs did not report. CONCLUSION: This study has obtained a more comprehensive and accurate data set of the normal allele frequencies and linkage disequilibrium parameters of HLA-DRB1,DQB1 in the Hans of north China, which may be of significance in the studies on population genetics and disease association.
Smad signalling in the ovary (2006)

It has now been a decade since the first discovery of the intracellular Smad proteins, the downstream signalling molecules of one of the most important growth factor families in the animal kingdom, the transforming growth factor beta (TGF-beta) superfamily. In the ovary, several TGF-beta superfamily members are expressed by the oocyte, granulosa and thecal cells at different stages of folliculogenesis, and they signal mainly through two different Smad pathways in an autocrine/paracrine manner. Defects in the upstream signalling cascade molecules, the ligands and receptors, are known to have adverse effects on ovarian organogenesis and folliculogenesis, but the role of the individual Smad proteins in the proper function of the ovary is just beginning to be understood for example through the use of Smad knockout models. Although most of the different Smad knockouts are embryonic lethal, it is known, however, that in Smad1 and Smad5 knockout mice primordial germ cell development is impaired and that Smad3 deficient mice harbouring a deletion in exon 8 exhibit impaired folliculogenesis and reduced fertility. In this minireview we discuss the role of Smad structure and function in the ovarian context.
MECHANISM OF BACTERIOPHAGE MU TRANSPOSITION (1986)

Orthologs and paralogs are two fundamentally different types of homologous genes that evolved, respectively, by vertical descent from a single ancestral gene and by duplication. Orthology and paralogy are key concepts of evolutionary genomics. A ...Read More
Sonochemistry in Environmental Remediation. 1. Combinative and Hybrid Sonophotochemical Oxidation Processes for the Treatment of Pollutants in Water (2005)

Sonoprocessing is the utilization of sonic and ultrasonic waves in chemical synthesis and processes. It is a new and rapidly growing research field with broad applications in environmental engineering, green chemical synthesis, and processing. The application of this environmentally benign technique in environmental remediation is currently under active research and development. Sonochemical oxidation is effective in treating toxic effluents and reducing toxicity. However, the ultrasonic treatment is highly energy intensive since sonication is relatively inefficient with respect to total input energy and is therefore not economically attractive or feasible alone. Hence, sonochemistry has not yet received much attention as an alternative for industrial and large-scale chemical and environmental processes. One of the most interesting topics in the recent advances in sonochemistry is the possibility of double or more excitations with ultrasound and other types of energy. The coupling of ultrasound with other free energy sources (i.e., UV) or chemical oxidation utilizing H2O2, O3, or ferrous ion presents interesting and attractive approaches. Therefore, many recent efforts have been devoted to improving the efficiency of sonochemical reactions by exploiting the advantages of combinative or hybrid processes involving the simultaneous or sequential use of ultrasonic irradiation and other advanced oxidation processes, electrochemical processes, and biological treatment. This paper provides a critical review of the applications of ultrasound in environmental remediation, focusing on recent developments and unifying analysis of combinative or hybrid systems, namely, sonophotochemical oxidation processes.
Method for automatic detection of defective ultrasound linear array transducers based on uniformity assessment of clinical images — A case study (2018)

The purpose of the present study was to test an idea of and describe a concept of a novel method of detecting defects related to horizontal nonuniformities in ultrasound equipment. The method is based on the analysis of ultrasound images collected directly from the clinical workflow. In total over 31000 images from three ultrasound scanners from two vendors were collected retrospectively from a database. An algorithm was developed and applied to the images, 150 at a time, for detection of systematic dark regions in the superficial part of the images. The result was compared with electrical measurements (FirstCall) of the transducers, performed at times when the transducers were known to be defective. The algorithm made similar detection of horizontal nonuniformities for images acquired at different time points over long periods of time. The results showed good subjective visual agreement with the available electrical measurements of the defective transducers, indicating a potential use of clinical images for early and automatic detection of defective transducers, as a complement to quality control.
Purification of acetylcholine receptors, reconstitution into lipid vesicles, and study of agonist-induced cation channel regulation. (1980)

We report the purification of acetylcholine receptors with active agonist-regulated cation channels from Torpedo californica electric organ tissue by five methods. In one method, previously used by others, contaminating proteins were removed from partially purified membranes by alkaline extraction, preserving membrane integrity throughout the procedure. In the other four methods, acetylcholine receptors were purified after solubalization with sodium cholate. The continual presence of soybean lipid in mixed micelles with cholate was required to prevent irreversible inactivation of the cation channel. Solubilized receptors were purified by affinity chromatography using either Naga naja siamensis toxin III or concanavalin A coupled to agarose. Sucrose gradient centrifugation was also used to purify solubilized receptors. The best method combined affinity chromatography on toxin-agarose and concanavalin A agarose. Receptors purified by all five methods were incorporated into soybean lipid vesicles by the cholate dialysis technique. The agonist-regulated cation channels of the receptors were equally active after reconstitution, independent of the method used for purification. All reconstituted vesicle preparations were similar in preferential orientation of acetylcholine receptor toward the external surface, dose-response to carbamylcholine, carbamylcholine-induced desensitization, and carbamycholine-induced influx of 22Na+ per mol of receptor. Carbamylcholine-induced 22Na+ influx/receptor was greater after reconstitution than in native vesicles. This was because, in native vesicles, carbamylcholine-induced 22Na+ influx was limited by equilibration of the internal volume of the vesicles with the external 22Na+ concentration, whereas in reconstituted vesicles 22Na+ influx was limited by desensitization of the receptor molecule. We demonstrate that only one of the two toxin binding sites on the receptor monomer, the one which can be affinity alkylated with 4-(N-maleimido)benzyltrimethylammonium, controls the carbamylcholine-induced opening of the cation channel.
[Combination of dacarbazine, cisplatin and interferon alpha in the treatment of metastatic melanoma]. (1996)

The aim of this work was to study the effectiveness and safety of a combined therapy with dacarbazine, cisplatin and interferon alpha in the treatment of metastatic melanoma.Sixteen patients, including 15 with one or more visceral metastases, were treated with dacarbazin 400 mg/m2, cisplatin 100 mg/m2 repeated every 28-day and interferon alpha-2a 3.10(6) IU subcutaneously 3 times weekly. Fifty percent of patients had at least 3 different sites of metastases. Ten patients had previously received one or more specific treatment for their melanoma.The overall response was 25 p. 100 (2 complete responses and 2 partial responses). The two complete responses were obtained on liver, lung and cutaneous metastases and remain in sustained, unmaintained remission for 22 and 24 months. Administration of this treatment was well tolerated, the most prevalent toxicity being hematologic. At present, responding patients have a median survival of 26 months+ since the beginning of the treatment, compared to 7 months for non responding patients.Dacarbazine and cisplatin combined chemotherapy has been used at various doses with an overall response rate of 14 to 37 p. 100, similar to our results. However, duration of complete response in our study (22 months+ and 24 months+) seem more prolonged than in studies using dacarbazine and cisplatin at dose of 100 mg/m2/21 d (7 to 9 months) and comparable to studies using dacarbazine and cisplatin at dose of 150 mg/m2/28 d or more (15 months+ to 19 months+ and 24 months+) but with less toxicity. Therefore addition of interferon alpha might be of interest in the maintain of complete remissions and perhaps in the prolongation of survival of responding patients as it has already been suggested with the dacarbazine-interferon alpha combination.
Feature Selection as an Improving Step for Decision Tree Construction (2011)

The removal of irrelevant or redundant attributes could benefit us in making decisions and analyzing data efficiently. Feature Selection is one of the most important and frequently used techniques in data preprocessing for data mining. In this paper, special attention is made on feature selection for classification with labeled data. Here an algorithm is used that arranges attributes based on their importance using two independent criteria. Then, the arranged attributes can be used as input one simple and powerful algorithm for construction decision tree (Oblivious Tree). Results indicate that this decision tree using featured selected by proposed algorithm outperformed decision tree without feature selection. From the experimental results, it is observed that, this method generates smaller tree having an acceptable accuracy.
Visualization and Measurements of Sub-Millisecond Transient Spray Dynamics Applicable to Direct Injection Gasoline Engine. Part 3: Measurements of Instantaneous and Integrated Flow Rates in High Pressure Injection System Using LDA-Based Meter. (1999)

Time-dependent centerline velocity is measured using LDA-flow meter. Swirl injector at frequencies of 22 and 46 Hz generates oscillated flow under high-pressure from 4 up to 7 MPa. The encoded time-series of velocity is used to reconstruct the time-variable series of instantaneous flow rate and pressure gradient. Transient injection dynamics are analyzed to obtain basec characteristics of an injection system that will be able to be used for real time monitoring or active controlling of high-pressure gasoline injectors. The results obtained through analyzing the integrated mass rates within a cycle, indicate that a certain injection system is characterized by the flow rate constant γ which independent on injection duration and can be obtained from only accurate measurement of centerline velocity in the fuel transport pipeline. The present technique allows us to simplify the injection model and can be effectively adopted for practical employment on active and passive control with respect to gasoline direct injection engines.
SYNOVITIS IN POLYMYALGIA RHEUMATICA (1975)

Synovitis was observed in 13 out of 88 consecutive patients with polymyalgia rheumatica. It is described in detail in five patients, on the basis of clinical radiological observations, joint aspiration, arthroscopy and biopsy. The synovitis of polymyalgia rheumatica cannot be distinguished histologically or at arthroscopy from the appearance seen in mild rheumatoid arthritis. Clinically, however, the synovitis of polymyalgia rheumatica is mild, transient and confined to one or two joints or tendon sheaths. It is not followed by joint deformity or by radiological erosive changes in the bone ends. It may occur at any stage of the disease but particularly at its onset, or when the dose of corticosteroid treatment is reduced.
Will Vaccines Be Available for the Next Influenza Pandemic? (2004)

For the first time in history, influenza vaccine could be available at the beginning of an influenza pandemic. This is the result of the removal of major technical barriers; however, political and economic hurdles remain. In this Policy Forum,
 the authors
 describe solutions outlined by the World Health Organization Influenza Programme for expediting progress and increasing market forces to develop influenza pandemic vaccines.
Incorporating Functional MR Imaging into Diffusion Tensor Tractography in the Preoperative Assessment of the Corticospinal Tract in Patients with Brain Tumors (2007)

Incorporating fMRI into DT tractography in the preoperative assessment of patients with brain tumors may provide additional information on the course of important white matter tracts and their relationship to the tumor. Only this approach allows a distinction between the CST components, while visualization of the CST is improved when fiber tracking is hampered by tumor (infiltration) or perifocal edema.
Local gene transfer of tissue factor pathway inhibitor regulates intimal hyperplasia in atherosclerotic arteries (2001)

Tissue factor (TF), the initiator of blood coagulation and thrombosis, is up-regulated after vascular injury and in atherosclerotic states. Systemic administration of recombinant TF pathway inhibitor (TFPI) has been reported to decrease intimal hyperplasia after vascular injury and also to suppress systemic mechanisms of blood coagulation and thrombosis. Here we report that, in heritable hyperlipidemic Watanabe rabbits, adenoviral gene transfer of TFPI to balloon-injured atherosclerotic arteries reduced the extent of intimal hyperplasia by 43% (P < 0.05) compared with a control vector used at identical titer (1 x 10(10) plaque-forming units/ml). Platelet aggregation and coagulation studies performed 7 days after local gene transfer of TFPI failed to show any impairment in systemic hemostasis. At time of sacrifice, 4 weeks after vascular injury, the 10 Ad-TFPI treated carotid arteries were free of thrombi, whereas two control-treated arteries were occluded (P, not significant). These findings suggest that TFPI overexpressed in atherosclerotic arteries can regulate hyperplastic response to injury in the absence of changes in the hemostatic system, establishing a role for local TF regulation as target for gene transfer-based antirestenosis therapies.
Profound Vitamin D Deficiency in a Diverse Group of Women during Pregnancy Living in a Sun-Rich Environment at Latitude 32°N (2010)

VDD was high in a diverse group of women, greatest in those of darker pigmentation. The negative correlation between 25(OH)D and PTH confirms their corroborative use as biomarkers of VDD. These findings raise the issue of adequacy of current vitamin D recommendations for pregnant women.