gebhart/patrepeval huggingface dataset:
Charging effects observed in<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">YBa</mml:mi></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">Cu</mml:mi></mml:mrow><mml:mrow><mml:mn>3</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">O</mml:mi></mml:mrow><mml:mrow><mml:mn>7</mml:mn><mml:mi mathvariant="normal">−</mml:mi><mml:mi mathvariant="italic">x</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math>films: Influence of oxygen ordering (1994)

The chain oxygen dynamics of ${\mathrm{YBa}}_{2}$${\mathrm{Cu}}_{3}$${\mathrm{O}}_{7\mathrm{\ensuremath{-}}\mathit{x}}$ have been investigated using a Monte Carlo simulation of the asymmetric next-nearest-neighbor Ising model for the oxygen atoms in the basal plane. The effect of an externally applied electric field is shown to change the basal plane coordination of Cu ions, resulting in a change in the carrier doping of the ${\mathrm{CuO}}_{2}$ planes. Good quantitative agreement is obtained with the asymmetry observed in field effect experiments. We present results under different applied external fields, study the long-term ordering dynamics and investigate the effect of oxygen content on the phenomenon. We discuss the relevance of our results to studies of point-contact spectroscopy, tunneling, electromigration, and the enhancement of superconductivity by photoexcitation. We also present a historical perspective in terms of the Verwey transition in ${\mathrm{Fe}}_{3}$${\mathrm{O}}_{4}$, which involves a similar mechanism.
<i>In Vivo</i> Pharmacodynamics of New Lipopeptide MX-2401 (2010)

MX-2401 is a novel lipopeptide (amphomycin analog) with a broad-spectrum bactericidal activity against Gram-positive organisms. We used murine thigh and lung infection models in neutropenic and normal mice to characterize the in vivo pharmacokinetic/pharmacodynamic (PK/PD) activities of MX-2401. The compound (2.5 to 40 mg/kg of body weight) demonstrated linear PK characterized by an area under the concentration-time curve (AUC) of 228 to 3,265 μg·h/ml and half-lives of 5.7 to 8.8 h. MICs ranged from 0.25 to 2 μg/ml. The in vivo postantibiotic effect was prolonged (8.5 h with Staphylococcus aureus and 10.3 to 12.3 with Streptococcus pneumoniae). MX-2401 exhibited dose-dependent in vivo activity against various strains of S. pneumoniae and S. aureus; penicillin and macrolide resistance in the pneumococci and methicillin resistance in the staphylococci had no impact on the antimicrobial activity of the drug. To determine which PK/PD index correlated best with MX-2401 activity, dose fractionation studies over a 72-hour period were performed. The maximum concentration of drug in serum divided by the MIC (C(max)/MIC) correlated best with the efficacy for both S. aureus and S. pneumoniae. Static doses required free-drug C(max)/MIC values of 0.683 to 1.06. Free-drug 72-h AUC/MIC values for the static dose were in the range of 7.49 to 32.3 and were less than expected. The drug showed modest enhancement in activity in the presence of white blood cells (1.7- to 3.4-fold). The potency of the drug in the lung was only marginally lower than in the thigh (1.3- to 1.9-fold). Based on its PK/PD profile, MX-2401 appears to be a promising new lipopeptide agent for treatment of infections by Gram-positive bacteria, including those induced by antibiotic-resistant pathogens.
Uptake of Organic Substrates and Accumulation of Polyhydroxyalkanoates Linked with Glycolysis of Intracellular Carbohydrates under Anaerobic Conditions in the Biological Excess Phosphate Removal Processes (1992)

Anaerobic uptake mechanisms of acetate, propionate and lactate by the sludge developed in an anaerobic aerobic biological phosphate removal process was investigated. Anaerobic batch experiments were conducted with these substrates, and mass balances of materials involved in substrate uptake metabolism were calculated. These substrates were accumulated in the sludge as polyhydroxyalkanoates composed of 3-hydroxybutyrate, 3-hydroxyvalerate, 3-hydroxy-2-methylbutyrate and 3-hydroxy-2-methylvalerate. The reducing power necessary for the formation of polyhydroxyalkanoates from acetate and/or propionate was shown to be supplied from glycolysis of intracellular carbohydrates. Lactate was converted to 3-hydroxyvalerate rich polyhydroxyalkanoate via acetyl-CoA and propionyl-CoA by using propionate fermentation pathway. Redox balance was found to be a factor regulating the anaerobic uptake of substrates and their further metabolism. Glycogen seemed to serve not only as a source of reducing power necessary for the redox balance regulation but also as an important energy source, because glycolysis can provide both reducing power and energy. It was indicated that some bacteria might be able to get energy necessary for substrate uptake under strict anaerobic conditions not by the polyphosphate hydrolysis but by the consumption of intracellular carbohydrates.
Compact microstrip parallel coupler with high isolation (2008)

A compact microstrip parallel coupler with high isolation is presented. Adopting the reflected power canceller approach, the developed coupler with dual transmission lines not only effectively enhances the directivity of the coupler, but also has compact size. For verification purposes, a proposed parallel coupler is fabricated and measured at 915 MHz. The proposed parallel coupler can obtain excellent isolation of −65 dB and directivity of −47.7 dB at 915 MHz. Simulated results are in good agreement with measured results, which verified the reliability of the designed coupler.
Effect of Geometry and Fluid Viscosity on Dynamics of Fluid‐Filled Cracks: Insights From Analog Experimental Observations (2020)

Abstract Fluid‐filled volumes in geological systems can change the local stress field in the host rock and may induce brittle deformation as well as crack propagation. Although the mechanisms relating fluid pressure perturbations and seismicity have been widely studied, the fluid‐solid interaction inside the crack of a host rock is still not well understood. An analog experimental model of fluid intrusion in cracks between planar layers has been developed to study stress conditions at the margins and tips. A combined high‐speed shadowgraph and a photoelasticity imaging system is used to visualize the fluid dynamics and induced stresses on the solid matrix. Cavitation, as well as bubble growth and collapse, occurs along the sawtooth crack margins, which produces a highly localized stress concentration to initiate new subcrack systems. The presence of the bubbles at the crack tip during fluid pressure perturbation can enhance crack propagation.
Vertical corner line detection on buildings in quasi-Manhattan world (2013)

An efficient algorithm is proposed for detecting vertical corner lines on buildings in quasi-Manhattan world scene. The vertical corner lines are useful geometric information of buildings in urban scene, whose importance is similar to that of corners on planar curves for various applications in computer vision. The algorithm employs a bottom-up and step-by-step pipeline processing procedure. First, straight-line segments are extracted as low-level features from the input building image by using a fast and accurate line segment detector. Secondly, the extracted straight-line segments are clustered to groups and associated to different vanishing points, which are computed by a J-Linkage estimator and act as the mid-level features. Finally, high-level features, vertical corner lines, are detected with several geometric constraints in quasi-Manhattan world. Experimental results demonstrate the efficiency of the new algorithm.
New <i>Monascus</i> Metabolite Isolated from Red Yeast Rice (Angkak, Red Koji) (2002)

Red yeast rice (angkak, red koji) obtained as cultures of Monascus purpureus on rice was extracted and analyzed by HPLC. In addition to the known red, orange, and yellow pigments and the mycotoxin citrinin, a new Monascus metabolite was detected. It is present in the original red yeast rice and formed in higher amounts when red yeast rice is heated. High-resolution mass spectrometry indicated the molecular formula C(15)H(12)O(4). The chemical structure was elucidated by analysis of NMR data. The new compound, named monascodilone, is characterized by a propenyl group on a pyrone ring, an aromatic ring, and a gamma-lactone group.
Analysis for computing heat conduction and fluid problems using cubic B-spline function (1998)

We make use of cubic B-spline interpolation function in two cases: heat conduction and fluid flow problems. Cubic B-spline test function is employed because it is superior to approximation of linear and non-linear problems. We investigated the accuracy of the numerical formulation and focused on the position of the breakpoints within the computational domain. When the domain is divided by partitions of equal space, the results show poor accuracy. For the case of a heat conduction problem this partition can not reflect the temperature gradient which is rapidly changed near the wall. To correct the problem, we have more grid points near the wall or the region which has a rapid change of variables. When we applied the unequally spaced breakpoints, the results show high accuracy. Based on the comparison of the linear problem, we extended to the highly non-linear fluid flow problems.
A Cooperative Framework for Information Browsing in Mobile Environment (2009)

Through pervasive computing, users can access information and applications anytime, anywhere, using any device. But as mobile devices such as Personal Digital Assistant (PDA), SmartPhone, and consumer appliance continue to flourish, it becomes a significant challenge to provide more tailored and adaptable services for this diverse group. To make it easier for people to use mobile devices effectively, there exist many hurdles to be crossed. Among them is small display size, which is always a challenge. Usually, applications and documents are mainly designed with desktop computers in mind. When browsing through mobile devices with small display areas, users’ experiences will be greatly degraded (e.g., users have to continually scroll through a document to browse). However, as users acquire or gain access to an increasingly diverse range of portable devices (Coles, Deliot, & Melamed, 2003), the changes of the display area should not be limited to a single device any more, but extended to the display areas on all available devices. As can be readily seen from practice, the simplest multi-device scenario is when a user begins an interaction on a first access device, then ceases to use the first device and completes the interaction using another access device. This simple scenario illustrates a general concern about a multi-device browsing framework: the second device should be able to work cooperatively to help users finish browsing tasks. In this article, we propose a cooperative framework to facilitate information browsing among devices in mobile environment. We set out to overcome the display constraint in a single device by utilizing the cooperation of multiple displays. Such a novel scheme is characterized as: (1) establishing a communication mechanism to maintain cooperative browsing across devices; and (2) designing a distributed user interface across devices to cooperatively present information and overcome the small display area limited by a single device.
Parametric Noise Injection: Trainable Randomness to Improve Deep Neural Network Robustness Against Adversarial Attack (2019)

Recent developments in the field of Deep Learning have exposed the underlying vulnerability of Deep Neural Network (DNN) against adversarial examples. In image classification, an adversarial example is a carefully modified image that is visually imperceptible to the original image but can cause DNN model to misclassify it. Training the network with Gaussian noise is an effective technique to perform model regularization, thus improving model robustness against input variation. Inspired by this classical method, we explore to utilize the regularization characteristic of noise injection to improve DNN's robustness against adversarial attack. In this work, we propose Parametric-Noise-Injection (PNI) which involves trainable Gaussian noise injection at each layer on either activation or weights through solving the Min-Max optimization problem, embedded with adversarial training. These parameters are trained explicitly to achieve improved robustness. The extensive results show that our proposed PNI technique effectively improves the robustness against a variety of powerful white-box and black-box attacks such as PGD, C&W, FGSM, transferable attack, and ZOO attack. Last but not the least, PNI method improves both clean- and perturbed-data accuracy, in comparison to the state-of-the-art defense methods, which outperforms current unbroken PGD defense by 1.1% and 6.8% on clean- and perturbed- test data respectively, using ResNet-20 architecture.
Kernel observers: systems-theoretic modeling and inference of spatiotemporally evolving processes (2016)

We consider the problem of estimating the latent state of a spatiotemporally evolving continuous function using very few sensor measurements. We show that layering a dynamical systems prior over temporal evolution of weights of a kernel model is a valid approach to spatiotemporal modeling, and that it does not require the design of complex nonstationary kernels. Furthermore, we show that such a differentially constrained predictive model can be utilized to determine sensing locations that guarantee that the hidden state of the phenomena can be recovered with very few measurements. We provide sufficient conditions on the number and spatial location of samples required to guarantee state recovery, and provide a lower bound on the minimum number of samples required to robustly infer the hidden states. Our approach outperforms existing methods in numerical experiments.
Androstene-17-thioketals. 1st communication: glucocorticoid receptor binding, antiproliferative and antiinflammatory activities of some novel 20-thiasteroids (androstene-17-thioketals). (1986)

The unique replacements of the alpha-hydroxyl and beta-ketol groups of corticoids at C17 with selected, simple alkylthio or (2-fluoroalkyl)thio groups resulted in the structurally novel steroids, C17-alkylthioketals of 9 alpha-fluoro-11 beta-hydroxy-androsta-1,4-diene-3,17-dione. The described androstene-17-thioketals (20-thiasteroids) had high affinities for the glucocorticoid receptor protein of rat liver cytosol. Most were more potent than triamcinolone acetonide, a clinically moderately potent corticoid, in antiproliferative and antiinflammatory activities in mice. Specifically, (11 beta, 17 alpha)-17-(ethylthio)-9 alpha-fluoro-11 beta-hydroxy-17-(methylthio) androsta-1,4-dien-3-one (tipredane, SQ 27,239) and (11 beta, 17 alpha)-17-(ethylthio)-9 alpha-fluoro-17-[2-(fluoroethyl)thio] - 11 beta - hydroxy-androsta-1,4-dien-3-one (SQ 28,300), topically applied, were as potent as halcinonide, a clinically highly potent corticoid, in inhibition of croton oil-induced edema in the mouse. It is suggested that both thiasteroids could be moderately to highly potent topical antiinflammatory agents in man.
Carbon coated porous nickel phosphides nanoplates for highly efficient oxygen evolution reaction (2016)

Prussian blue analogue (PBA)-derived carbon coated porous nickel phosphides nanoplates exhibit enhanced electrocatalytic activity for oxygen evolution reaction.
GaAs binary frequency dividers for high speed applications up to 10 GHz (1981)

Very high speed GaAs frequency dividers with a maximum operating frequency of 10 GHz are proposed. The dividers are based on a two-phase dynamic logic concept. Breadboard and simulation results are presented and discussed.
Identification of Compounds in Adlay (<i>Coix lachryma-jobi</i> L. var. <i>ma-yuen</i> Stapf) Seed Hull Extracts That Inhibit Lipopolysaccharide-Induced Inflammation in RAW 264.7 Macrophages (2009)

We investigated the effects of adlay seed hull (AH) extracts on the lipopolysaccharide-induced inflammatory response in RAW 264.7 macrophages. An AH ethanol extract (AHE) was partitioned into ethyl acetate, n-butanol, and water fractions. Silica gel chromatography of the ethyl acetate fraction yielded 15 subfractions: AHE-Ea-A to AHE-Ea-O. Subfractions AHE-Ea-J, AHE-Ea-K, and AHE-Ea-M had anti-inflammatory activities, as they counteracted the increased cellular production of nitric oxide and prostaglandin E2 induced by lipopolysaccharide by down-regulating inducible nitric oxide synthase and cyclooxygenase 2 expression. Eriodictyol (1), the ceramide (2S,3S,4R)-2-[(2'R)-2'-hydroxytetracosanoyl-amino]-1,3,4-octadecanetriol (2), and p-coumaric acid (3) were found in the subfractions, and the first two compounds appeared to be primarily responsible for the anti-inflammatory activity. This is the first time that eriodictyol (1) and this ceramide (2) have been found in AH, and the anti-inflammatory properties of the AHE-Ea fraction can be attributed, at least in part, to the presence of these two compounds.
Perturbational profiling of nanomaterial biologic activity (2008)

Our understanding of the biologic effects (including toxicity) of nanomaterials is incomplete. In vivo animal studies remain the gold standard; however, widespread testing remains impractical, and the development of in vitro assays that correlate with in vivo activity has proven challenging. Here, we demonstrate the feasibility of analyzing in vitro nanomaterial activity in a generalizable, systematic fashion. We assessed nanoparticle effects in a multidimensional manner, using multiple cell types and multiple assays that reflect different aspects of cellular physiology. Hierarchical clustering of these data identifies nanomaterials with similar patterns of biologic activity across a broad sampling of cellular contexts, as opposed to extrapolating from results of a single in vitro assay. We show that this approach yields robust and detailed structure-activity relationships. Furthermore, a subset of nanoparticles were tested in mice, and nanoparticles with similar activity profiles in vitro exert similar effects on monocyte number in vivo. These data suggest a strategy of multidimensional characterization of nanomaterials in vitro that can inform the design of novel nanomaterials and guide studies of in vivo activity.
Identification of a New Human Catenin Gene Family Member (ARVCF) from the Region Deleted in Velo–Cardio–Facial Syndrome (1997)

Velo-cardio-facial syndrome (VCFS) and DiGeorge syndrome (DGS) are characterized by a wide spectrum of phenotypes, including conotruncal heart defects, cleft palate, and facial dysmorphology. Hemizygosity for a portion of chromosome 22q11 has been detected in 80-85% of VCFS/DGS patients. Both syndromes are thought to be the result of a developmental field defect. Using two independent gene-isolation procedures, we isolated a new catenin family member termed ARVCF (armadillo repeat gene deleted in VCFS) from the interval deleted in VCFS. ARVCF encodes a protein of 962 amino acids that contains a coiled coil domain and 10 tandem armadillo repeats. The primary structure of the protein is most closely related to the murine catenin p120CAS, which suggests a role for ARVCF in protein-protein interactions at adherens junctions. ARVCF is expressed ubiquitously in all fetal and adult tissues examined. This gene is hemizygous in all VCFS patients with interstitial deletions. Based on the physical location and potential functions of ARVCF, we suggest that hemizygosity at this locus may play a role in the etiology of some of the phenotypes associated with VCFS.
Correlation between adhesion hysteresis and phase state of monolayer films (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCorrelation between adhesion hysteresis and phase state of monolayer filmsManoj K. Chaudhury and Michael J. OwenCite this: J. Phys. Chem. 1993, 97, 21, 5722–5726Publication Date (Print):May 1, 1993Publication History Published online1 May 2002Published inissue 1 May 1993https://pubs.acs.org/doi/10.1021/j100123a043https://doi.org/10.1021/j100123a043research-articleACS PublicationsRequest reuse permissionsArticle Views389Altmetric-Citations89LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
ON THE USE OF MONTE CARLO METHODS FOR SOLVING GAMMA RADIATION TRANSPORT PROBLEMS (1964)

A description is given of various Monte Carlo programs that were developed for the Ferranti Mercury Computer solving gamma backscattering and penetration problems in plane, spherical, and cylindrical geometries. The energy region covered is 10 Mev to 10 kev. Results of several sample problems of interest in radiation physics and reactor shielding are presented. (auth)
Tyrosine Kinase Inhibitors for the Treatment of Rheumatoid Arthritis (2013)

Tyrosine kinases (TK) are enzymes capable of transferring phosphate groups to tyrosine residues in cytoplasmic proteins or the intracellular domains of transmembrane receptors. TK play critical roles in diverse biological functions including cellular processes such as adhesion, motility, proliferation, cell cycle control, cell death, as well as biological functions at the whole-organism level such as growth and development, metabolism or immune defense. TK inhibitors including spleen TK (fostamatinib) and Janus kinases (tofacitinib) inhibitors are two novel oral therapies that have demonstrated short-term good clinical responses in active rheumatoid arthritis patients with and inadequate responses to methotrexate or other traditional (non-biologic) disease-modifying antirheumatic drugs (DMARDs). Those responses are comparable to responses rates from pivotal trials of TNF inhibitors. TK inhibitors are generally well tolerated but not free of adverse effects. Several side effects had been described including gastrointestinal symptoms, neutropenia, hypertension, elevated liver function test and lipid alterations among others. Owing to the limited duration of follow-up of patients treated with TK inhibitors, the long term safety profile of these drugs are unknown.
An experimental digital consumer HDTV recorder using MC-DCT video compression (1993)

The concept and real-time implementation of an experimental home-use digital HDTV recorder is presented. An advanced motion-compensated DCT bit-rate reduction system is used to realize high-quality images at 50 Mbit/s only, thereby enabling small recording mechanics for portable applications and featuring a new high-efficiency channel code with embedded tracking information.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>