gebhart/patrepeval huggingface dataset:
Operations on action streams for hypermedia presentation (2003)

To support cooperative work of users on computers, use of facilities to record user's actions is very effective. Furthermore, such records can be required to select the specified actions. We are developing action history view mechanisms that record the action stream of presentation on hypermedia, generate an action history view by applying operations from the recorded action stream, and replay the action history view. Although action history views can be used in various cooperative work, we restrict this to the presentation on a hypermedia environment. In this environment, an action (including voice explaining the material) is recorded as a tuple of a component and an operation to the component. An action stream is defined as a list of recorded actions (tuples). An action history view is a list that contains necessary actions obtained from one or more action streams. The basic way to generate an action history view is to remove the operations related to the unnecessary components or inappropriate components because of security problems. The following functions are expected by presentation systems with action history view mechanisms: asynchronous presentation; reduction of replay time; keeping security; support to create or edit presentations; and synchronous playing of action sequences. We have been developing a prototype system of a hypermedia presentation system realizing the above mentioned operations on action streams.
Synthesis of Low-Polydispersity Miktoarm Star Copolymers via a Simple “Arm-First” Method: Macromonomers as Arm Precursors (2008)

Miktoarm star copolymers with variable arm compositions, high star yield (>85%), and low polydispersity (Mw/Mn < 1.2) were successfully synthesized by a simple “arm-first” method, one-pot cross-linking a mixture of linear macromonomers (MMs) and/or macroinitiators (MIs), via the atom transfer radical polymerization (ATRP) technique. Characterization of the star product by liquid adsorption chromatography proved that the star polymers obtained by cross-linking different MMs and MIs were miktoarm stars containing two arm species in one molecule. The incorporation of MM into miktoarm star molecule increased the star molecular weight and the average number of arms but did not change the number of initiating sites in the star core because the initiating sites independently originated from the incorporated MIs or low molar mass ATRP initiators. By using lower amount of initiator, the molar ratio of initiating sites to incorporated arms in the miktoarm star was decreased, which effectively reduced the extent of star−star coupling reactions and resulted in the formation of miktoarm star copolymers with low polydispersity. The molar ratios of arms in the miktoarm star copolymers were in agreement with the composition of initial MMs and/or MIs mixture. During the cross-linking reaction of a mixture of two MMs, addition of extra cross-linker and low molar mass initiator increased the molecular weight and yield of the miktoarm star molecules while preserving their low polydispersity.
Pay for performance in critical care: An executive summary of the position paper by the Society of Critical Care Medicine* (2009)

Egol, Andrew DO, MBA, FCCM; Shander, Aryeh MD, FCCM; Kirkland, Lisa MD, FACP; Wall, Michael H. MD, FCCM; Dorman, Todd MD, FCCM; Dasta, Joe MSc, FCCM; Bagwell, Sandra MD, FCCM; Kaufman, David MD, FCCM; Matthews, Paul Jr EdS, RRT, FCCM; Greenwald, Bruce M. MD, FCCM; Herr, Daniel L. MD, MS, FCCM; Stavish, Cynthia RN, MSN, CCRN; Thompson, Carol PhD, FCCM; Fahy, Brenda G. MD, FCCM Author Information
External fixation of distal radial fractures. (1983)

Results with four different external fixation frames were analyzed in a consecutive series of 100 unstable distal radial fractures of the Colles type. Overall, the numbers of good to excellent results, range of motion, and incidence of complications were similar for each group. Quadrilateral frame fixation of unstable distal radial fractures provides effective immobilization and produces good to excellent results in 86% of patients.
Associations of sedentary lifestyle, obesity, smoking, alcohol use, and diabetes with the risk of colorectal cancer. (1997)

Variation in colorectal cancer rates between countries and within ethnic groups upon migration and/or Westernization suggests a role for some aspects of Western lifestyle in the etiology of this disease. We conducted a population-based case-control study in the multiethnic population of Hawaii to evaluate associations between colorectal cancer and a number of characteristics of the Western lifestyle (high caloric intake, physical inactivity, obesity, smoking, and drinking) and some of their associated diseases. We interviewed in person 698 male and 494 female United States-born or immigrant Japanese, Caucasian, Filipino, Hawaiian, and Chinese patients diagnosed in 1987-1991 with colorectal cancer and 1192 population controls matched on age, sex, and ethnicity. Conditional logistic regression was used to estimate odds ratios adjusting for dietary and nondietary risk factors. Place of birth and duration of residence in the United States were unrelated to colorectal cancer risk. Energy intake (independent of the calorie source) and body mass index were directly associated with risk, and lifetime recreational physical activity was inversely associated with risk. The associations with these factors were independent of each other, additive (on the logistic scale) and stronger in men. When individuals were cross-categorized in relation to the medians of these variables, those with the higher energy intake and body mass index and lower physical activity were at the highest risk (for males, OR, 3.0; 95% confidence interval, 1.8-5.0, and for females, OR, 1.7; 95% confidence interval, 1.0-3.2). Smoking in the distant, as well as recent, past and alcohol use were directly associated with colorectal cancer in both sexes. Individuals with a history of diabetes or frequent constipation were at increased risk for this cancer, whereas past diagnosis of hypercholesterolemia was inversely associated with risk. The findings were consistent between sexes, among ethnic groups, and across stages at diagnosis, making bias an unlikely explanation. These results confirm the data from immigrant studies that suggest that the increase in colorectal cancer risk experienced by Asian immigrants to the United States occurred in the first generation because we found no difference in risk between the immigrants themselves and subsequent generations. They also agree with recent findings that suggest that high energy intake, large body mass, and physical inactivity independently increase risk of this disease and that a nutritional imbalance, similar to the one involved in diabetes, may lead to colorectal cancer.
How Do Xanthan and Hydroxypropyl Methylcellulose Individually Affect the Physicochemical Properties in a Model Gluten‐Free Dough? (2011)

Two types of hydrocolloids, xanthan gum and HPMC, were individually added to a gluten-free rice cassava formulation. Based on the thermoanalytic and rheological studies on dough, as well as the bread quality studies, high methoxy HPMC at 5% addition was determined to optimally improve the bread quality when only gum addition was considered. This study indicates the potential use of high methoxy HPMC as an additive in gluten-free bread formulations prior to considering alternative proteins.
Fibre optic pressure sensor for downhole monitoring in the oil industry (2000)

Available from British Library Document Supply Centre-DSC:DXN037964 / BLDSC - British Library Document Supply Centre
Viral Harvey ras p21 expressed in Escherichia coli purifies as a binary one-to-one complex with GDP. (1985)

The ras oncogene of Harvey murine sarcoma virus encodes a 21,000-dalton protein, p21, which mediates transformation. Viral Harvey ras p21, cloned into Escherichia coli HB101 lambda/pRAS1, has been purified to homogeneity by a three-step procedure. The purified E. coli p21 can be bound by a monoclonal antibody to viral Harvey ras p21 and has an amino acid composition consistent with that predicted from its DNA sequence. Purified E. coli p21 has been shown by HPLC analysis on an ion-exchange column to contain near stoichiometric amounts of GDP. This noncovalently associated GDP is seen in the UV absorption spectrum of the purified protein. The noncovalently associated GDP acts as a competitive inhibitor of the interaction of added guanine nucleotides with p21.
A High Speed Gas Handling System for the Brookhaven National Laboratory Three Stage Tandem Van De Graaff Facility (1969)

This paper describes a gas handling system for model MP Van de Graaff accelerators, using components with high pumping capacities together with gas temperature controls and heat exchangers to limit the temperature changes that accompany rapid gas pumping.
An immunologist's view of herpes simplex keratitis: Thygeson Lecture 1996, presented at the Ocular Microbiology and Immunology Group meeting, October 26, 1996. (1997)

Herpes stromal keratitis is a CD4+ T cell-dependent inflammatory process in which PMN infiltration and destruction of the cornea are regulated, at least in part, by the T-helper type 1 (Th1) cytokines IL-2 and IFN-gamma.
A cross-platform analysis of 14,177 expression quantitative trait loci derived from lymphoblastoid cell lines (2013)

Gene expression levels can be an important link DNA between variation and phenotypic manifestations. Our previous map of global gene expression, based on ~400K single nucleotide polymorphisms (SNPs) and 50K transcripts in 400 sib pairs from the MRCA family panel, has been widely used to interpret the results of genome-wide association studies (GWASs). Here, we more than double the size of our initial data set with expression data on 550 additional individuals from the MRCE family panel using the Illumina whole-genome expression array. We have used new statistical methods for dimension reduction to account for nongenetic effects in estimates of expression levels, and we have also included SNPs imputed from the 1000 Genomes Project. Our methods reduced false-discovery rates and increased the number of expression quantitative trait loci (eQTLs) mapped either locally or at a distance (i.e., in cis or trans) from 1534 in the MRCA data set to 4452 (with <5% FDR). Imputation of 1000 Genomes SNPs further increased the number of eQTLs to 7302. Using the same methods and imputed SNPs in the newly acquired MRCE data set, we identified eQTLs for 9000 genes. The combined results identify strong local and distant effects for transcripts from 14,177 genes. Our eQTL database based on these results is freely available to help define the function of disease-associated variants.
Flexible bandwidth allocation in high-capacity packet switches (2002)

This paper introduces a protocol for scheduling of packets in high-capacity switches, termed weighted sequential greedy scheduling (WSGS). WSGS is a simple, greedy algorithm that uses credits to reserve bandwidth for input-output pairs. By using a pipeline technique, WSGS implemented by the current technology readily supports a switching capacity exceeding 1 Tb/s. Admission control is straightforward, allowing bandwidth reservations on a submillisecond time scale. Namely, the central controller readily determines if the newly requested bandwidth can be assigned to the given input-output pair. We have shown that a newly requested bandwidth should be assigned if both the input and output have enough capacity, which requires checking of only two inequalities. Therefore, WSGS is well suited for switching in data networks where sessions might require high bit rates and last for a short time. The WSGS allows bandwidth reservations with fine granularity, e.g., bandwidth can be reserved for individual web sessions, video streams, etc.
Resource Saving Approach of Visual Tracking Fiducial Marker Recognition for Unmanned Aerial Vehicle (2015)

Unmanned aerial vehicle (UAV) tracking fiducial marker is a challenging problem, because of camera system vibration, which causes visible frame-to-frame jitter in the airborne videos and unclear marker vision. Multirotors have very limited weight carrying, controller, and battery power resources. While obtaining and processing motion blurred images, which have no useful information, requires much more image processing subsystem resources. The paper presents blurry image frame elimination based approach of UAV resource saving fiducial marker visual tracking. The proposed approach integrates accelerometer and visual data processing algorithms to predict image blur and skip blurred frames. Experiments have been performed to verify the validity of the proposed approach.
Line-Focus-Beam Acoustic Microscopy Detection of Variations of Growing Conditions of LiTaO<sub> 3</sub> Crystals (1999)

Line-focus-beam (LFB) acoustic microscopy is applied to evaluate the homogeneities of optical-grade LiTaO 3 single crystals, pulled along the crystallographic Y axis. Z-cut substrates prepared from three kinds of single crystals with different chemical compositions of 48.0, 48.5, and 49.0 Li 2 O-mol% as the starting materials, and one commercially available optical-grade congruent LiTaO 3 single crystal, are examined by measuring the leaky surface acoustic wave (LSAW) velocities along the Y axis. Using the relationship between the LSAW velocities and chemical compositions obtained from the three crystals, some significant and characteristic velocity variations of 0.54 m/s along the pulling-axis direction and of at most 0.38 m/s along the diameter direction were observed on the congruent specimen surface, corresponding to the chemical composition changes of 0.017 and 0.012 Li 2 O-mol%, respectively. This is the first evidence to signify that the variations are in essence due to changes of the crystal growing conditions during the growth process.
Microcycle-based Efficiency of Hybrid Vehicle Batteries (2005)

This paper shows the results of experimental tests carried out on two types of batteries for electric vehicles to evaluate their efficiency when subjected to small cycles (microcycles) around operating points characterised by different states of charge. These efficiency data can de useful for designer of energy manager systems for hybrid-electric vehicles to choose the right operating point for the vehicle storage.
Dual Inhibition of <i>RET</i> and <i>FGFR4</i> Restrains Medullary Thyroid Cancer Cell Growth (2005)

Medullary thyroid cancer is frequently an aggressive form of carcinoma for which there are currently no effective forms of systemic therapy. These carcinomas arise as a result of activating mutations in the RET proto-oncogene transmembrane tyrosine kinase receptor. We, therefore, examined the potential efficacy of the tyrosine kinase inhibitor STI571 on the growth of human TT medullary cancer cells in vitro and in xenografted severe combined immunodeficiency mice. Treatment with STI571 resulted in inhibition of RET phosphorylation, cell proliferation, tumor growth and invasiveness. Based on the profile of expression of fibroblast growth factor receptors (FGFR), we examined the effects of FGFR tyrosine kinase inhibition using the small molecule FGFR inhibitor PD173074. This inhibitor resulted in abrogation of fibroblast growth factor-1-mediated FGFR4 phosphorylation in TT cells, an effect that was accompanied by significant arrest of cell proliferation and tumor growth in vivo. Moreover, the combination of STI571 and PD173074 resulted in greater suppression of cell proliferation in vitro and tumor control in vivo than that achieved with either agent alone. These data highlight RET and FGFR4 as therapeutic targets and suggest a potential role for the combined use of tyrosine kinase inhibitors in the management of inoperable medullary thyroid cancers.
<title>Analysis of temperature and stress effects in fiber optic gyroscopes (Proceedings Only)</title> (1992)

We review the Sagnac effect in the application of the fiber optic gyroscope. Non-reciprocal phase shifts resulting from environmentally-induced fluctuations in polarization-maintaining (PM) fiber parameters are investigated theoretically and experimentally. It is pointed out, based on our earlier measurements, that temperature and stress cause random perturbations in fibers designed for gyroscope applications. Analysis for the experimental data are presented. The data at low temperature show large noise that rule out some PM fibers for high accuracy applications.
Increased Erythrocyte Lithium-Sodium Countertransport in Essential Hypertension: Its Relationship to Family History of Hypertension (1981)

1. Erythrocyte lithium--sodium countertransport was measured in 46 normotensive healthy controls without family history of hypertension, 15 subjects with essential hypertension, but without evidence of family history of high blood pressure, and 43 subjects with essential hypertension and at least one hypertensive first-degree relative. 2. Mean values (mmol h-1 l-1 of erythrocytes) were 0.248 +/- 0.092 in controls, 0.258 +/- 0.087 in hypertensive subjects without family history (not significant vs controls), 0.360 +/- 0.115 in hypertensive subjects with family history of hypertension (P less than 0.001 vs controls), 0.334 +/- 0.117 in all hypertensive subjects, both with and without family history (P less than 0.001 vs controls). 3. Our data confirm the finding of an increased erythrocyte lithium--sodium countertransport, but with a significant overlap between essential hypertension and control values. Lithium--sodium countertransport is higher only in hypertensive subjects with at least one hypertensive first-degree relative. 4. We suggest that the increase of lithium--sodium countertransport in erythrocytes is not a consistent marker of essential hypertension. It seems to be associated with the family prevalence and/or the hereditability of hypertension, rather than with high blood pressure per se.
A comparative study between hand-assisted laparoscopic splenectomy and open splenectomy in combination with pericardial devascularization to treat portal hypertension (2011)

Objective To investigate the changes in liver function and the efficacy of either hand-assisted laparoscopic surgery (HALS) or open splenectomy (OS) in combination with pericardial devascularization in the treatment of portal hypertension. Methods The clinical data of 94 patients who received splenectomy combined with pericardial devascularization to treat portal hypertension due to cirrhosis from Jan 2002 to May 2008 were analyzed retrospectively. 56 patients received OS and 38patients HALS. The operating time, intraoperative blood loss, postoperative complications, liver dysfunction and mortality were analyzed according to the Child's grading. Results There was no difference in the operating time between HALS and OS (P＞0. 05). The intraoperative blood loss and postoperative complications were 5.6% and 10.8%, respectively (P＜0. 05). There was no significant difference in the serum ALT between HALS and OS, but there was a significant difference in the ALB (P＜0. 05). The AST also had a significant difference on postoperative day 5 (P＜0. 05). The serum ALT and AST were elevated after HALS, but there was a significant difference only for AST (P＜0.05). The serum ALT and AST in OS were significantly higher after than before operation (P＜0. 05). The serum ALB in OS was significantly lower after operation (P＜0.05), but it was significantly lower only on postoperative days 1 and 3 (P＜0.05) in HALS. Conclusions Compared with OS, HALS combined with pericardial devascularization caused less damage to the intestinal tract and the liver function. It is a feasible and safe operation and it had fewer postoperative complications.

Key words: 
Hand-assisted laparoscopy; Portal hypertension; Cirrhosis; Splenectomy; Pericardial devascularization
Synthesis of <i>N</i>-Fmoc-<i>O</i>- (<i>N</i>‘-Boc-<i>N</i>‘-methyl)-aminohomoserine, an Amino Acid for the Facile Preparation of Neoglycopeptides (2002)

The synthesis of N-Fmoc-O-(N'-Boc-N'-methyl)-aminohomoserine in 35% overall yield from l-homoserine is described. This amino acid can be efficiently incorporated into peptides using Fmoc-chemistry-based solid-phase peptide synthesis, and the resulting peptides can be chemoselectively glycosylated at the aminooxy side chains to generate neoglycopeptides. The synthesis of this derivative greatly expands the availability of a previously developed neoglycopeptide synthesis strategy.
Detecting cell-secreted growth factors in microfluidic devices using bead-based biosensors (2017)

Microfluidic systems provide an interesting alternative to standard macroscale cell cultures due to the decrease in the number of cells and reagents as well as the improved physiology of cells confined to small volumes. However, the tools available for cell-secreted molecules inside microfluidic devices remain limited. In this paper, we describe an integrated microsystem composed of a microfluidic device and a fluorescent microbead-based assay for the detection of the hepatocyte growth factor (HGF) and the transforming growth factor (TGF)-β1 secreted by primary hepatocytes. This microfluidic system is designed to separate a cell culture chamber from sensing chambers using a permeable hydrogel barrier. Cell-secreted HGF and TGF-β1 diffuse through the hydrogel barrier into adjacent sensing channels and are detected using fluorescent microbead-based sensors. The specificity of sensing microbeads is defined by the choice of antibodies; therefore, our microfluidic culture system and sensing microbeads may be applied to a variety of cells and cell-secreted factors.
Prevalence of <i>Porphyromonas gingivalis</i> and Periodontal Health Status (1998)

Periodontitis is a common, progressive disease that eventually affects the majority of the population. The local destruction of periodontitis is believed to result from a bacterial infection of the gingival sulcus, and several clinical studies have provided evidence to implicate Porphyromonas gingivalis. If P. gingivalis is a periodontal pathogen, it would be expected to be present in most subjects with disease and rarely detected in subjects with good periodontal health. However, in most previous studies, P. gingivalis has not been detected in the majority of subjects with disease, and age-matched, periodontally healthy controls were not included for comparison. The purpose of the study reported here was to compare the prevalence of P. gingivalis in a group with periodontitis to that of a group that is periodontally healthy. A comprehensive sampling strategy and a sensitive PCR assay were used to maximize the likelihood of detection. The target sequence for P. gingivalis-specific amplification was the transcribed spacer region within the ribosomal operon. P. gingivalis was detected in only 25% (46 of 181) of the healthy subjects but was detected in 79% (103 of 130) of the periodontitis group (P < 0.0001). The odds ratio for being infected with P. gingivalis was 11.2 times greater in the periodontitis group than in the healthy group (95% confidence interval, 6.5 to 19.2). These data implicate P. gingivalis in the pathogenesis of periodontitis and suggest that P. gingivalis may not be a normal inhabitant of a periodontally healthy dentition.
CGC using a programmable electronic pressure controller (1990)

Abstract Capillary gas chromatographic separations were performed with an electronic pressure control system developed to provide precise closed‐loop control of inlet pressure through the use of a solid state micro‐machined pressure sensor and electronically controlled proportional valve. The closed‐loop control of the electronic system provided better precision than the open‐loop control achieved by manual pressure regulation. Closed‐loop control can perform pressure programming, which can be combined with temperature programming to optimize separations. The pressure sensor monitors the integrity of the flow system and singals the controller to reduce flow in the presence of a sudden loss of system pressure.