gebhart/patrepeval huggingface dataset:
A Branch-and-Price Method for a Liquefied Natural Gas Inventory Routing Problem (2010)

We consider a maritime inventory routing problem in the liquefied natural gas (LNG) business, called the LNG inventory routing problem (LNG-IRP). Here, an actor is responsible for the routing of the fleet of special purpose ships, and the inventories both at the liquefaction plants and the regasification terminals. Compared to many other maritime inventory routing problems, the LNG-IRP includes some complicating aspects such as (1) a constant rate of the cargo evaporates each day and is used as fuel during transportation; (2) variable production and consumption of LNG, and (3) a variable number of tanks unloaded at the regasification terminals. The problem is solved by a branch-and-price method. In the column generation approach, the master problem handles the inventory management and the port capacity constraints, while the subproblems generate the ship route columns. Different accelerating strategies are implemented. The proposed method is tested on instances inspired from real-world problems faced by a major energy company.
A new method of parameter estimation from progress curves. (1984)

A mathematical procedure is presented which permits kinetic parameters to be determined from progress curve data. The method is applicable to any kind of enzymatic reaction which can be described by a single rate equation. A general criterion is derived to check the accuracy of the method. An application to a simulated 2-substrate reaction is given.
Efficacy and safety of secukinumab in patients with generalized pustular psoriasis: A 52‐week analysis from phase <scp>III</scp> open‐label multicenter Japanese study (2016)

Generalized pustular psoriasis (GPP) is a severe inflammatory skin disease characterized by the presence of sterile pustules covering almost the entire body and systemic symptoms such as fever. Secukinumab, a fully human-recombinant anti-interleukin-17A monoclonal antibody was indicated for psoriasis vulgaris and psoriatic arthritis in Japan but is not yet investigated for GPP. In this phase III, open-label multicenter single arm study, the efficacy and safety of secukinumab as monotherapy or with co-medication was evaluated in 12 Japanese patients with GPP. All the patients received secukinumab 150 mg s.c. at baseline, week 1, 2, 3 and 4, and then every 4 weeks. Two non-responders were up-titrated to 300 mg. Change in GPP severity from baseline was evaluated by clinical global impression (CGI) categorized as "worsened", "no change", "minimally improved", "much improved" or "very much improved". Treatment success was achieved by 83.3% (n = 10) of patients at week 16 (primary end-point) with CGI evaluated as "very much improved" (n = 9) and "much improved" (n = 1). Moreover, the area of erythema with pustules improved as early as week 1 and resolved by week 16 in most of the patients. The improvements were sustained throughout 52 weeks. Over the 52-week treatment period, secukinumab was well tolerated with no unexpected safety signals. Nasopharyngitis, urticaria, diabetes mellitus and arthralgia were the frequent adverse events reported. The data from this study shows that secukinumab can become one of the potent treatment options for GPP.
Robotic Assisted Reduction of Femoral Shaft Fractures using Stewart Platform (2009)

A robotic system with 6 DOF mobility was proposed for reduction of femoral shaft fractures based on Stewart platform. A plan for implementing the platform on bone fragments was introduced and a step by step strategy for performing the reduction procedure, based on the system's inverse kinematic solution, was proposed. The efficacy of the system was evaluated in some case studies and it was shown that it can be locked to act as an external fixator.
A Spectrum Matching Technique for Enhancing Image Contrast (1966)

Interpretation of imagery requires contrast between the object being sought and its background. A technique is described for increasing the contrast of selected objects based on their spectral reflectance or emittance characteristics, and two applications are discussed. Means for implementing this technique with an optical-mechanical scanner, multielement dispersing spectrometer, and electronic signal processing equipment are discussed.
Routing Protocol for Hybrid Ad Hoc Network using Energy Prediction Model (2008)

Hybrid ad hoc networks are integrated networks referred to Home Networks, Telematics and Sensor networks can offer various services. Specially, in ad hoc network where each node is responsible for forwarding neighbor nodes' data packets, it should net only reduce the overall energy consumption but also balance individual battery power. Unbalanced energy usage will result in earlier node failure in overloaded nodes. it leads to network partitioning and reduces network lifetime. Therefore, this paper studied the routing protocol considering efficiency of energy. The suggested algorithm can predict the status of energy in each node using the energy prediction model. This can reduce the overload of establishing route path and balance individual battery power. The suggested algorithm can reduce power consumption as well as increase network lifetime.
Structure of a (3+1) hybrid G-quadruplex in the <i>PARP1</i> promoter (2018)

Poly (ADP-ribose) polymerase 1 (PARP1) has emerged as an attractive target for cancer therapy due to its key role in DNA repair processes. Inhibition of PARP1 in BRCA-mutated cancers has been observed to be clinically beneficial. Recent genome-mapping experiments have identified a non-canonical G-quadruplex-forming sequence containing bulges within the PARP1 promoter. Structural features, like bulges, provide opportunities for selective chemical targeting of the non-canonical G-quadruplex structure within the PARP1 promoter, which could serve as an alternative therapeutic approach for the regulation of PARP1 expression. Here we report the G-quadruplex structure formed by a 23-nucleotide G-rich sequence in the PARP1 promoter. Our study revealed a three-layered intramolecular (3+1) hybrid G-quadruplex scaffold, in which three strands are oriented in one direction and the fourth in the opposite direction. This structure exhibits unique structural features such as an adenine bulge and a G·G·T base triple capping structure formed between the central edgewise loop, propeller loop and 5' flanking terminal. Given the highly important role of PARP1 in DNA repair and cancer intervention, this structure presents an attractive opportunity to explore the therapeutic potential of PARP1 inhibition via G-quadruplex DNA targeting.
BMP signaling in vascular diseases (2012)

Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-β (TGF-β) family that signal via type I and type II serine/threonine kinase receptors and intracellular Smad transcription factors. BMPs are multifunctional regulators of development and tissue homeostasis and they were initially characterized as inducers of bone regeneration. Genetic studies in humans and mice showed that perturbations in BMP signaling lead to various diseases, such as skeletal diseases, vascular diseases and cancer. Mutations in BMP type II receptor and BMP type I receptor/activin receptor-like kinase 1 have been linked to pulmonary arterial hypertension and hereditary hemorrhagic telangiectasia, respectively. BMPs have also been implicated in promoting vascular calcification and tumor angiogenesis. In this review we discuss the role of BMP signaling in vascular diseases and the value of BMP signaling as a vascular disease marker or a therapeutic target.
Full-screen, scrollable APL2 spreadsheet input/output editor (1993)

A full-screen, scrollable, spreadsheet-like editor based on IBM's APL2 32-bit interpreter for 386/486-based microcomputers is described. It is used for entering, examining, analyzing, editing and printing data. Mixed numeric and character arrays can be read in from or written out to formatted DOS files (ASCII) or comma-delimited DOS files. Alternatively, a bulk mode input facility allows for rapid direct data entry, or data can be entered, examined and edited cell-by-cell in the usual way. A facility for coding missing values is also provided. No numerical coding of the data is needed. Columns, rows or blocks of data can be highlighted in a chosen color, shadowed, moved or copied. In addition, APL functions entered on the command line can use the blocks as input or output. The full notational and computational power of APL is available. Major-to-minor (lexicographic) sorts can be performed on selected columns, and conditional or unconditional frequency tabulations and cross-tabulations of selected columns can be performed. Output from these statistical calculations is obtained as a new spreadsheet, or equivalently, as an APL2 matrix. In particular, two-way cross-tabulations of multiple columns are laid out in the spreadsheet like draftsmen's plots to facilitate investigation and explanation of multivariate categorical data.
난소암에 있어서 혈청 CA 125항원 역가에 관한 연구 (1991)

난소암 환자에서, 혈청내 CA 125 역가치를 수술 전에 병리조직학적 유형과 암기, 조직학적 세포분화도 종양 크기 별로 특정했으며, 또한 수술후 항암화학요법 동안 측정한 결과 다음과 같은 결론을 얻었다. 1. 혈청내 CA 125 역가치는 장액성낭선암에서 타 유형에 비해 비교적 높게 나타났다. 2. CA 125 역가치의 양성율은 임상적 암기가 진행 될 수록 높게 나타났다. 3. 암 세포의 미분화도와 종양 크기는 CA 125 역가치와 상관관계가 없었다. 4. 수술 후 1회 항암화학요법에 따른 CA 125 역가치와 상관관계가 없었다. 4. 수술 후 1회 항암화학요법에 따른 CA 125 역가치는 난소암 환자 20명중 11명에서 50%∼100%의 감소율을, 5명에서는 30%∼50%의 감소율을 나타냈으며, 나머지 4명은 30%미만의 감소율을 보였고, 특히 장액성낭선암에서 3회 항암화학요법후 1례를 제외하고 모두 CA 125 역가치가 35U/ml이하로 회복되었다. 5. 예측도와 민감도는 장액성낭선암에서는 각각 75%, 60%로 나타났다. 이상의 결과로 CA 125 역가치는 장액성낭선암에서 다른 조직학적 유형에 비해 진단 예후 및 항암화학요법후 추적조사에 유용함을 알 수 있었다.
The “Optical Funnel”. A Technique for Measuring a Microorganism's Power (1998)

A novel and potentially useful optical technique called an “optical funnel” has been developed. The technique utilizes a system in which a microorganism is suspended by equilibrium between the medium flow and the radiation pressure applied in the opposite direction. At equilibrium, i.e., when the force of the laser pressure is equal to the force of the moving stream, the microorganism is captured. At this point, it has the ability to escape on its own power. Since the force applied to the microorganism is calculated on the basis of a ray-optics model, it is possible to measure the magnitude of the microorganism's power. A Trachelomonas volvocina cell was determined to have a power of ∼1 pN. This technique is superior to the laser trapping technique, which is currently used in these determinations, since it is possible to capture numerous organisms in a single experiment, thus allowing the calculation of the average power for an organism with minimal effort, in terms of repetitive samplings and measurements.
Neonatal thrombosis (2000)

Neonatal thromboembolic events, both arterial and venous, are rare but increasingly recognised problems in tertiary care neonatology. The pathophysiology of these events in the context of the neonatal haemostatic system and the importance of both inherited and acquired prothrombotic disorders remain poorly defined. Similarly, optimal diagnostic and therapeutic approaches in this setting are not currently based on sound clinical evidence, and there is a clear need to investigate these issues, which will inevitably require large multicentre studies.
Carbon-13 NMR of carbon monoxide. I. Pressure dependence of translational motion in β-CO (1977)

Activation parameters for self-diffusion of carbon monoxide molecules have been studied in the hexagonal beta phase of CO as a function of pressure and temperature. The carbon-13 nuclear transverse relaxation time T2, which is proportional to the average molecular jump rate τ−1, was measured by the Carr–Purcell Meiboom–Gill method. The activation enthalpy increases from 13 to 16 kJ/mole between 0 and 1.75 kbar and the activation volume is 44±5 cm3/mole, which corresponds to 1.5 molar volumes. The results indicate a single diffusion mechanism in this P–T range; most probably the diffusion takes place by migration of monovacancies.
Direct Synthesis of 1-Aminoalkanephosphonic and 1-Aminoalkanephosphinic Acids from Phosphorus Trichloride or Dichlorophosphines (1978)

Carbonylverbindungen (I) und Benzylurethan (II) ergeben in siedendem Eisessig mit Phosphortrichlorid nach Hydrolyse 1-Aminoalkanphosphonsauren (III) und mit Dichlorphosphanen (IV) 1-Aminoalkanphosphinsauren (V).
SMARTPATH, AN AUTOMATED HIGHWAY SYSTEM SIMULATOR (1992)

This paper presents SmartPath, an Automated Highway System (AHS) simulator. The paper summarizes the key design features of the AHS and the assumption underlying the design, namely, the availability of certain elements: vehicles with appropriate sensors and actuators; highways with appropriate sensors; the ability to communicate between vehicles and between a vehicle and the highway. The paper explains how the simulation is organized, and an example illustrates the use of SmartPath.
392. The preparation and heats of combustion of some amine nitrates (1951)

T. L. Cottrell and J. E. Gill, J. Chem. Soc., 1951, 1798 DOI: 10.1039/JR9510001798
Uptake of 22Na+ by cultured dog kidney cells (MDCK). (1979)

22Na+ uptake measurements were conducted on the dog kidney cell line, MDCK, to determine the mechanism of ouabain-insensitive sodium transport. The radioisotope was found to be taken up into monolayer cultures via an ATP-independent, saturable process (Km = 40 mM). The presence of sodium on the opposite side of the membrane gave rise to a transstimulation of the 22Na+ flux. Studies utilizing potassium and valinomycin suggested that the transport system was insensitive to changes in the membrane potential. Replacement of chloride in the assay buffer with other anions did not decrease the rate of 22Na+ uptake at 14 mMNa+, but bicarbonate and acetate were stimulatory. Potassium and rubidium increased the rate of 22Na+ influx (Ka = 13mM with 14 mM NaCL in the medium). Lithium (Ki = 7.5mM) and amiloride (Ki = 1.7 x 10(-5) M) were competitive and partially (or mixed) competitive inhibitors, respectively. The data are consistent with a mechanism of sodium uptake that includes a carrier(s) capable of catalyzing net sodium uptake and sodium-sodium exchange.
Synchronization of a variable frequency source with a fixed frequency source using a sliding-mode controller (2002)

The authors show the synthesis of a sliding-mode controller using Lyapunov stability theory. One way of synchronizing the Superconducting Super Collider (SSC) low energy booster with the medium energy booster is by matching the longitudinal phase of the designated RF buckets of two machines throughout acceleration to a pre-programmed trajectory. This makes the synchronization predictable in advance. The model associated with the phase-locking is time-varying and model parameters are subjected to disturbance due to errors in the bending magnetic field. Also, the disturbance could be due to other feedback loops such as a B-field loop or a beam phase loop in the system. The measured phase error between the two reference waves may not be accurate. The design of a sliding-mode controller for such an application is considered. In the absence of measurement errors and parameter uncertainties and with no disturbance, the controller reduces to a classical gain feedback.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
270 nm Pseudomorphic Ultraviolet Light-Emitting Diodes with Over 60 mW Continuous Wave Output Power (2013)

In this letter, the achievement of over 60 mW output power from pseudomorphic ultraviolet light-emitting diodes in continuous wave operation is reported. Die thinning and encapsulation improved the photon extraction efficiency to over 15%. Improved thermal management and a high characteristic temperature resulted in a low thermal rolloff up to 300 mA injection current with an output power of 67 mW, an external quantum efficiency (EQE) of 4.9%, and a wall plug efficiency (WPE) of 2.5% for a single-chip device emitting at 271 nm in continuous wave operation.
Coherent artifacts in optical coherence tomography: observation and cancellation (2002)

OCT images can be degraded severely by coherent sidelobes of the source. Sidelobes, can introduce false targets if no targets are present at the sidelobe locations, and also add constructively or destructively to the targets that are present at the sidelobe locations, resulting in cancellation of the true targets or display of incorrect echo amplitudes of the targets. The authors introduce the use of CLEAN, a nonlinear deconvolution algorithm, to cancel coherent sidelobes in OCT images of extracted human teeth. The results show that CLEAN can reduce the coherent artifacts to the noise background, sharpen the air-enamel and enamel dentin interfaces and improve the image contrast.
Iron supplementation generates hydroxyl radical in vivo. An ESR spin-trapping investigation. (1995)

Electron spin resonance (ESR) spectroscopy has been used to investigate hydroxyl radical generation in rats with chronic dietary iron loading. A secondary radical spin-trapping technique was used where hydroxyl radical forms methyl radical upon reaction with DMSO. The methyl radical was then detected by ESR spectroscopy as its adduct with the spin trap alpha-phenyl-N-t-butylnitrone (PBN). This adduct was detected in the bile of rats 10 wk after being fed an iron-loading diet and 40 min after the i.p. injection of the spin trap PBN dissolved in DMSO. Bile samples were collected into a solution of the ferrous stabilizing chelator 2,2'-dipyridyl in order to prevent the generation of radical adducts ex vivo during bile collection. Identification of the ESR spectrum of the major radical adduct as that of PBN/.CH3 provides evidence for the generation of the hydroxyl radical during iron supplementation. Desferal completely inhibited in vivo hydroxyl radical generation stimulated by high dietary iron intake. No radical adducts were detected in rats which were fed the control diet for the same period of time. This is the first evidence of hydroxyl radical generation in chronic iron-loaded rats.
Feasibility study for precise lunar landing using SELENE-B lander configuration (2005)

This paper concerns the evaluation of a guidance and control system for lunar landing. The lander, which is supposed to have the same configuration of SELENE-B (SELenological and ENgineering Explorer-B), is required to land precisely at a site where there are scientifically important features, with minimal fuel consumption while avoiding surface obstacles such as rocks and small craters which might jeopardize the landing. The guidance and control system are designed for this aim, and the feasibility of the landing is tested by Monte Carlo simulation. The results, however, indicated that the original configuration and landing sequence are not appropriate for precise and safe landing. Therefore, based on the results, the configuration and landing sequence are modified and tested by Monte Carlo simulation again.
Mass defect profiles of biological matrices and the general applicability of mass defect filtering for metabolite detection (2008)

Recent examples have demonstrated that the high-resolution liquid chromatography/mass spectrometry (LC/MS)-based mass defect filtering (MDF) technique was effective in selectively detecting drug metabolites regardless of their molecular weights or fragmentation patterns. The main objective of the current study was to evaluate the general applicability of MDF for drug metabolite detection in typical biological matrices. Mass defect profiles of commonly used biological matrices including plasma, urine, bile, and feces were obtained using an LTQ FT mass spectrometer and were compared with those of 115 commonly prescribed drugs. The mass defect profiles were presented as two-dimensional Y-X plots with the determined mass defects of components on the y-axis versus the corresponding m/z values on the x-axis. The mass defect profiles of the matrices appeared to be similar for each type of matrix across species, yet marked differences were apparent between matrices of a given species. The mass defect profiles of components in plasma, bile, and feces showed significant separation from most of the 115 drugs. The mass defect profiles of urine did not show such clean separation from that of the 115 drugs. The results suggest that MDF has a broad applicability for selective detection of drug metabolites in plasma, bile and feces although the selectivity for detecting urinary drug metabolites is not as good as in the other matrices. In addition, the mass defect profiles of the biological matrices allow for prediction of the effectiveness of MDF for certain applications, and for designing specific MDF windows for selective detection of drug metabolites.
Sequential estimation of observation error variances in a trajectoryestimation problem. (1967)

Sequential trajectory estimation improved by implementing simple running estimates of observation error variances
Parallel architectures for digital optical computing and their design principles (1990)

Some architectural characteristics of digital optical computing systems are discussed. F.issential issues such as functional architectures, machine levels, instruction steps, and instruction complexities in the design of parallel digital optical computers are presented. `I he design of an optical cellular logic computer gives an example.
Agent-based collaborative negotiation for manufacturing supply chain coordination (2005)

This paper applies the multiagent system paradigm to collaborative negotiation in manufacturing supply chain coordination. Multiagent computational environments are suitable for studying a broad class of coordination and negotiation issues involving multiple autonomous or semiautonomous problem solving agents. A case study of mobile phone global manufacturing supply chain coordination is reported.
Fabrication of a Polymer High-Aspect-Ratio Pillar Array Using UV Imprinting (2013)

This paper presents UV imprinting methods for fabricating a high-aspect-ratio pillar array. A polydimethylsiloxane (PDMS) mold was selected as the UV imprinting mold. The pillar pattern was formed on a 50 × 50 mm2 area on a polyethylene terephthalate (PET) film without remarkable deformation. The aspect ratios of the pillar and space were about four and ten, respectively. The mold was placed into contact with a UV-curable resin under a reduced pressure, and the resin was cured by UV light irradiation after exposure to atmospheric pressure. The PDMS mold showed good mold releasability and high flexibility. By moderately pressing the mold before UV-curing, the thickness of the residual layer of the imprinted resin was reduced and the pattern was precisely imprinted. Both batch pressing and roll pressing are available.
Geist: a generator for e-commerce & internet server traffic (2005)

This paper describes Geist, a traffic generator for stress testing of web servers. The generator provides a large number of dialable parameters that allow traffic characteristics to range from simple static web-page browsing to the transactional traffic seen by e-commerce front end servers. Unlike other traffic generators, our generator concentrates on the characteristics of the aggregate traffic arriving at the server, which allows for better control of the scaling properties of the traffic and a more scalable generation. In this paper, we describe the traffic characterization and generation process that Geist is based on. We also present the performance of our current implementation, instances of its usage and directions for future work.