gebhart/patrepeval huggingface dataset:
Map-based lane and obstacle-free area detection (2014)

Abstract: With the emergence of intelligent Advanced Driving Assistance Systems (i-ADAS), the need for effective detection of vehicular surroundings is considered a necessity. The effectiveness of such systems directly depends on their performance in various environments such as rural and urban roads, and highways. Most of the current lane detection techniques are not suitable for urban roads with complex lane shapes and frequent occlusions. We propose a map-based lane detection approach which can robustly detect the lanes in urban and rural environments, and highways. We also present an algorithm for detecting obstacle-free areas in detected lanes based on the stereo depth maps of driving scenes. Experiments show that our approach reliably detects lanes and obstacle free areas within them, even in case of partially occluded or worn-off lane markers. 1
NO{sub x} reduction by compact electron beam processing (1995)

Among the new methods being investigated for the post-combustion removal of nitrogen oxides (NO{sub x}) are based on non-thermal plasmas. These plasmas can be produced by electrical discharge methods or electron beam irradiation. The application of electron beam irradiation for NO{sub x} removal in power plant flue gases has been investigated since the early 1970`s in both laboratory- and pilot-scale experiments. Electrical discharge methods are relatively new entrants in the field of flue gas cleanup. Pulsed corona and dielectric-barrier discharge techniques are two of the more commonly used electrical discharge methods for producing nonthermal plasmas at atmospheric pressure. There are basically two types of reactions responsible for the depletion of NO by non-thermal plasmas: oxidation and reduction.
Polymer shells by the droplet method (1981)

An acoustically modulated fluid jet (AMFJ) is used to generate a stream of identical droplets of a polymer solution by the breakup of a column of polymer solution resulting from Rayleigh jet instabilities. Selected droplets from this stream are then charged and deflected by an electric field into a vertical furnace. As the solvent evaporates, a polymer bubble is formed which hardens into a shell by the time it reaches the bottom of the furnace. By varying the polymer, solvent, temperature, and droplet size, we have been able to make polymer shells with a wide range of selected diameters and aspect ratios. Using an AMFJ, we have produced various polymer shells with narrow distributions of diameters.
IFN- <i>gamma</i> gene expression in pancreatic islet-infiltrating mononuclear cells correlates with autoimmune diabetes in nonobese diabetic mice. (1995)

Insulin-dependent diabetes mellitus in nonobese diabetic (NOD) mice results from selective destruction of pancreatic islet beta-cells following islet infiltration by mononuclear leukocytes. Cytokines produced by islet-infiltrating mononuclear cells may be involved in beta-cell destruction. Therefore, we analyzed cytokine mRNA expression, by reverse-transcriptase PCR (RT-PCR) assay, in mononuclear leukocytes isolated from pancreatic islets of four groups of mice: diabetes-prone female NOD mice; female NOD mice protected from diabetes by injection of CFA at an early age; male NOD mice with a low diabetes incidence; and female BALB/c mice that do not develop diabetes. We found that mRNA levels of IL-1 beta, IL-2, IL-4, IL-10, and IFN-gamma in mononuclear cells from islets of diabetes-prone female NOD mice increased progressively as these cells infiltrated the islets from age 5 wk to diabetes onset (> 13 wk). However, only IFN-gamma mRNA levels were significantly higher in islet mononuclear cells from 12-wk-old diabetes-prone female NOD mice than from less diabetes-prone NOD mice (CFA-treated females, and males) and normal mice (BALB/c). In contrast, IL-4 mRNA levels were lower in islet mononuclear cells from diabetes-prone female NOD mice than from NOD mice with low diabetes incidence (CFA-treated females and males). Splenic cell mRNA levels of IFN-gamma and IL-4 were not different in the four groups of mice. These results suggest that islet beta-cell destruction and diabetes in female NOD mice are dependent upon intra-islet IFN-gamma production by mononuclear cells, and that CFA-treated female NOD mice and male NOD mice may be protected from diabetes development by down-regulation of IFN-gamma production in the islets.
Oligomerization activity of a double‐stranded RNA‐binding domain (2004)

Xenopus laevis RNA-binding protein A (Xlrbpa) is a highly conserved, ubiquitously expressed hnRNP- and ribosome-associated RNA-binding protein that contains three double stranded RNA-binding domains (dsRBDs) in tandem arrangement. A two-hybrid screen with Xlrbpa as a bait recovered Xlrbpa itself as the strongest interaction partner, indicating multimerization of this protein. To search for regions responsible for the observed interaction, we conducted two-hybrid assays with Xlrbpa deletion constructs and identified the third dsRBD of Xlrbpa as the exclusive interacting domain. Additionally, these results were confirmed by coimmunoprecipitation experiments with truncated proteins expressed both in yeast and Xenopus oocytes. In PACT, the human homologue of Xlrbpa, we could demonstrate that the third dsRBD displays the same multimerization activity. Interestingly, this domain is essential for the activation of the dsRNA-activated protein kinase PKR. Addition of RNAses to coimmunoprecipitation experiments did not affect the dimerization, suggesting that the interaction is independent of RNA-binding. We report here a homomultimerization activity of a type B dsRBD and suggest possible implications that include a model for PKR activation by PACT.
Novel application of lentiviral vectors towards treatment of graft-versus-host disease (2009)

Allogeneic transplantation of hematopoietic stem cells and lymphocytes is a curative treatment for malignant and non-malignant disease. However, the primary complication limiting the safety of transplantation is graft-versus-host disease (GvHD), which is mediated by donor T cells. Strategies for pre- and post-transplant manipulation of graft cells are not yet optimal for balancing GvHD severity with beneficial Graft-versus-Leukemia (GvL) effects. Emerging cell fate control gene therapy (CFCGT)-based strategies, such as 'suicide' gene therapy for donor T cell regulation, can supplement existing transplantation approaches by providing a safety element to reduce GvHD. Past uses of CFCGT in the clinic have provided proof-of-principle that GvHD can be controlled by such a strategy. However, there exists a need for improved transgene delivery and suicide control systems. Recently, lentiviral vectors (LVs) have emerged as effective gene delivery vehicles for the clinic. Combining lentiviral gene delivery with newer generations of 'suicide' systems that possess improved enzyme/prodrug specificities, activities, and reduced immunogenicity, could provide the necessary degree of control required to more successfully manage GvHD. Improving the safety of transplantation through successful CFCGT will serve to expand the potential donor pool and the spectrum of disorders that can be treated by this therapeutic schema.
Discussion: “A General Solution for the Elastoplastic Thermal Stresses in a Strain-Hardening Plate With Arbitrary Material Properties” (Mendelson, A., and Spero, S. W., 1962, ASME J. Appl. Mech., 29, pp. 151–158) (1962)

The solution presented in Professor Sidebottom's discussion also fails to include the effect of large strain, which is believed to be the main feature of the paper.Discrepancies as high as 16 percent between theoretical and experimental loads are observed in columns, according to Table 1, which is not lower than the discrepancy found by Professor Sidebottom between his solution and the example of the paper.Finally, the author believes that the comparison of the loads, for the same critical time, based on two entirely different creep laws reveals very little about the correctness of either law. A General Solution for tie Elastoplastic Thermal Stresses in a Strain-Hardening Plate With Arbitrary Material Properties 1
Dynamic Modeling of Human 5-Lipoxygenase–Inhibitor Interactions Helps To Discover Novel Inhibitors (2012)

Human 5-lipoxygenase (5-LOX) is one of the key anti-inflammatory drug targets due to its key role in leukotrienes biosynthesis. We have built a model for the active conformation of human 5-LOX using comparative modeling, docking of known inhibitors, and molecular dynamics simulation. Using this model, novel 5-LOX inhibitors were identified by virtual screen. Of the 105 compounds tested in a cell-free assay, 30 have IC(50) values less than 100 μM and 11 less than 10 μM with the strongest inhibition of 620 nM. Compounds 4, 7, and 11 showed strong inhibition activity in the human whole blood (HWB) assay with IC(50) values of 8.6, 9.7, 8.1 μM, respectively. Moreover, compounds 4 and 7 were also found to inhibit microsomal prostaglandin E synthase (mPGES)-1 with micromolar IC(50) values, similar to licofelone, a dual functional inhibitor of 5-LOX/mPGES-1. The compounds reported here provide new scaffolds for anti-inflammatory drug design.
A Haptic Interaction Method Using Visual Information and Physically Based Modeling (2009)

Haptic feedback can be used to sense a physical environment at a remote site in order to overcome spatial or scale barriers in telemanipulation. The aim of this paper is to develop a haptic interaction method for a deformable object manipulation system by means of image processing and physically based modeling techniques. The interaction forces between the instrument driven by a haptic device and a deformable object are inferred in real time based on the visual information from a slave environment without force sensor. A physically based model of the deformable object is constructed by integrating the geometric information from vision, <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">a priori</i> knowledge of the object mechanical properties, and a predefined coordinate system of the slave environment. The forces are then derived from the model, while a boundary condition is updated based on the images (a tool-tip position tracking). In order to demonstrate the applicability and effectiveness of the proposed algorithm, macro- and microscale experimental systems were built and equipped with a telemanipulation system and a commercial haptic display. The proposed method was verified using silicone (macroscale) and zebrafish embryos (microscale).
Parapoxviruses: From the Lesion to the Viral Genome (2002)

Viruses of the genus parapoxvirus from the family poxviridae cause widespread but localized diseases of small and large ruminants. The economically most important disease is contagious pustular dermatitis or contagious ecthyma among sheep and goats, often simply called orf. The parapoxviruses (PPV) can be transmitted to man leading to localized lesions that are named pseudocowpox or milkers' node as being mostly restricted to the hands and fingers. In cattle two forms of PPV manifestation are commonly observed, the bovine papular stomatitis in young calves and the occurrence of lesions at the udder of cows. We here report about the recent efforts in molecular characterization of orf viruses and the state of the art about the generation of orf virus recombinants. In addition the current knowledge on immune responses against orf viruses and some new data on the behaviour of orf virus recombinants under non-permissive conditions are reported.
A wireless network based on the combination of Zigbee and GPRS (2008)

Due to its low-power consumption, low-cost, self-organization and powerful ability to route data, ZigBee, an emerging wireless network technology, has plenty of applications; GPRS (general packet radio service) network, a convenient way to access Internet, covers widely nowadays. This paper combines GPRS and ZigBee to establish a multi-mode network structure which employs GPRS as the data transmission device in the wide-area while ZigBee in the local area. This kind of network structure, providing a simple way to setup wireless network between terminal equipment, remote devices and personal stuff, will make the data servicing people freely.
Maximizing wind farm energy production in presence of aerodynamic interactions (2014)

Wind energy is an attractive alternative to fossil fuels. However, as many other types of renewable energy sources, efficient control strategies development implies many challenges due to the dynamic and unpredictable behaviour of the energy source. More specifically, the variability of the wind velocity and the aerodynamic interactions between wind turbines reduce the electrical power production of wind farms. Extremumseeking control (ESC) is one way to reduce the power losses due to the wake effect in wind farm. In this paper, the multi-unit optimization (MUO) method has been used in order to maximize in real-time the extracted power of the wind farm of 6 wind turbines taking in consideration the wake effect. The use of MUO method is made possible by the definition of a novel objective function which considers a normalized power regardless of wind speed inputs. Simulation results show that using the MUO method lead to a fast convergence to the optimal operational point of the wind farm even in presence of a disturbed wind.
Synthesis, DNA binding, sequence preference and biological evaluation of minor groove-selective N1-alkoxyalkyl-bis-benzimidazoles. (1994)

The synthesis and characterization of two groups of N1-alkoxyalkyl-bis-benzimidazoles are described. These groups of agents, that differ in the orientation of the N3-alkoxyalkyl group with respect to the minor groove of the DNA receptor, were designed to examine the structural requirements of molecular recognition of these minor groove-selective anticancer agents. The relative binding of the 12 agents to poly(dA-dT), determined by ethidium displacement in C50 values, ranged from 0.62 to 14.20 micrograms/ml. Sequence-preferential binding, established by complementary strand MPE.Fe(II) footprinting, was predominantly AT selective, but with significantly enhanced GC recognition in the cases of those ligands bearing an accessible pyridine N directed inwards to the minor groove. Binding site sizes were generally 5 +/- 1 base pairs. Cytotoxicities against KB human tumor cells ranged from 0.93 to 46.59 micrograms/ml. The most potent agent 6c, which also showed the strongest DNA binding, is of the 'r-inward-directed' type. The stringent structural requirements within the alkoxyalkyl R group for potency suggest additional specific interactions or chemical reaction of 6c within the groove that more than compensate for the increased steric hindrance.
Induction of arthritis by single monoclonal IgG anti‐collagen type II antibodies and enhancement of arthritis in mice lacking inhibitory FcγRIIB (2003)

IgG anti-collagen type II (CII) antibodies (Ab) can induce arthritis in healthy mice. Here we have investigated if single monoclonal IgG anti-CII Ab can induce arthritis in CIA-susceptible DBA/1 mice and if there is an IgG subclass dependency. The involvement of Fc receptors for IgG (FcgammaR) in anti-CII Ab-mediated arthritis was also investigated by comparing the clinical outcome in DBA/1 mice to those in FcgammaR-deficient mice. We demonstrate for the first time that single mAb to naive DBA/1 mice can induce persistent arthritis. Histology of the inflamed joints revealed massive cellular infiltrate and cartilage and bone destruction. All IgG subclasses tested (IgG1, IgG2a and IgG2b) were arthritogenic, with the IgG1 and IgG2b isotypes as the dominating arthritogenic Ab. Pathogenicity was dependent on engagement of activating FcgammaR, as FcRgamma-deficient mice were completely resistant to Ab-mediated arthritis. The arthritis induced with the IgG1 and IgG2b Ab was also inhibited by FcgammaRIII disruption, whereas arthritis mediated by the IgG2a Ab was not substantially affected. The arthritic response of the IgG1 and IgG2b isotypes, but not of the IgG2a Ab, was further enhanced in mice lacking the inhibitory FcgammaRIIB. These results demonstrate that single IgG anti-CII mAb can induce erosive arthritis and that IgG anti-CII Ab mediate arthritis by engagement of FcgammaR.
Ventricular Fibrillation Induction Using Nonsynchronized Low Energy External Shock During Rapid Ventricular Pacing: Method of Induction When Fibrillation Mode of ICD Fails (1996)

Third-generation implantable cardioverter defibrillators (ICD) are frequently implanted with nonthoracotomy systems and provide noninvasive methods for electrical stimulation and ventricular fibrillation induction. These modalities facilitate postoperative testing of the ICD. Rapid right ventricular burst pacing via the defibrillator is commonly used for initiation of ventricular tachyarrhythmias. However, with the available third-generation devices, ventricular fibrillation (VF) induction may be impossible in up to 19% of the patients. In these cases, transvenous placement of a right ventricular catheter has been required to generate VF and appropriately evaluate the device. We report a new technique of noninvasive induction of VF using a low energy external nonsynchronized shock delivered during ICD fibrillation induction pacing. In three patients, after all efforts to induce VF by the Ventritex Cadence V-100 had failed, a 20 J nonsynchronized shock was delivered during rapid RV pacing. This resulted in VF on the first attempt in all patients. This noninvasive technique of VF initiation may provide a useful clinical approach to ICD testing that eliminates the costs and risks of an invasive procedure.
Simulation of creping pattern in tissue paper (2012)

Abstract The key operation in tissue production is the creping at the Yankee cylinder. The tissue sheet is adhered to a Yankee cylinder and then detached from the surface with a blade. As a result a strong microstructure - crepe folds - is generated on the web. In this work the structure of creping pattern in CD and MD of tissue paper was studied. The samples available in this work consisted of bath tissue and towel grades. The significant difference between the samples was in the number of crepe folds. The tissue sheets were analyzed with an imaging system. The variation of crepe folds in images was studied in spatial frequency space through 2D Welch spectrum. It was noticed that the difference in creping pattern structure between the samples can be seen clearly in spectra. The creping pattern was simulated based on the creping pattern variation found from the Welch spectra of tissue paper images. The simulation was based on a set of sinusoidal terms representing several orientations and amplitudes. The amplitudes of sinusoidal terms located in regular grid in spectra were approximated with 2D normal distribution. Thus, the structure of creping pattern can be represented with three parameters originating from the deviations and location of 2D normal distribution. The creping pattern reconstructed with simulations contains the relevant features in the creping pattern of true tissue images.
Selected dietary (poly)phenols inhibit periodontal pathogen growth and biofilm formation (2014)

Periodontitis (PD) is a chronic infectious disease mediated by bacteria in the oral cavity. (Poly)phenols (PPs), ubiquitous in plant foods, possess antimicrobial activities and may be useful in the prevention and management of periodontitis. The objective of this study was to test the antibacterial effects of selected PPs on periodontal pathogens, on both planktonic and biofilm modes of growth. Selected PPs (n = 48) were screened against Streptococcus mitis (S. mitis), Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans), Fusobacterium nucleatum (F. nucleatum) and Porphyromonas gingivalis (P. gingivalis). The antibacterial potential of each compound was evaluated in terms of planktonic minimum inhibitory concentration (PMIC) and planktonic minimum bactericidal concentration (PMBC) using standardized broth microdilution assays. The most active PPs were further tested for their effect on mono-species and multi-species biofilms using a colorimetric resazurin-based viability assay and scanning electron microscopy. Of the 48 PPs tested, 43 showed effective inhibition of planktonic growth of one or more test strains, of which curcumin was the most potent (PMIC range = 7.8-62.5 μg mL(-1)), followed by pyrogallol (PMIC range = 2.4-2500 μg mL(-1)), pyrocatechol (MIC range = 4.9-312.5 μg mL(-1)) and quercetin (PMIC range = 31.2-500 μg mL(-1)). At this concentration, adhesion of curcumin and quercetin to the substrate also inhibited adhesion of S. mitis, and biofilm formation and maturation. While both curcumin and quercetin were able to alter architecture of mature multi-species biofilms, only curcumin-treated biofilms displayed a significantly reduced metabolic activity. Overall, PPs possess antibacterial activities against periodontopathic bacteria in both planktonic and biofilm modes of growth. Further cellular and in vivo studies are necessary to confirm their beneficial activities and potential use in the prevention and or treatment of periodontal diseases.
Mild and stereocontrolled synthesis of iodo- and bromohydrins by halogen-tetrakis(isopropoxy)titanium opening of epoxy alcohols (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMild and stereocontrolled synthesis of iodo- and bromohydrins by halogen-tetrakis(isopropoxy)titanium opening of epoxy alcoholsEleuterio Alvarez, Maria Teresa Nunez, and Victor S. MartinCite this: J. Org. Chem. 1990, 55, 11, 3429–3431Publication Date (Print):May 1, 1990Publication History Published online1 May 2002Published inissue 1 May 1990https://pubs.acs.org/doi/10.1021/jo00298a002https://doi.org/10.1021/jo00298a002research-articleACS PublicationsRequest reuse permissionsArticle Views727Altmetric-Citations59LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
The effect of physical changes in a furnished indoor environment on Wireless Local Area Network (WLAN) signals (2014)

Abstract-- This paper describes the investigation of the effect on the Wireless Local Area Network (WLAN) signals due to fixed and non-fixed variables in indoor environment. The measurement system consisted of a spectrum analyzer and a log-periodic antenna. Line-of-sight (LOS) and non-line-of-sight (NLOS) propagation (in furnished rooms) were discussed. All the measurement sites mentioned in this paper are located in the Division of Information Technology at Universiti Putra Malaysia. The furnished rooms included a teaching laboratory, a computer laboratory, and an operating office plus a server room. The effects of the various types of materials at the measurement sites also are described here. 1.