gebhart/patrepeval huggingface dataset:
Improved heat sinking for laser-diode arrays using microchannels in CVD diamond (1997)

This work proposes a novel cooling system for high-power laser-diode arrays, for which the maximum optical output power density per unit surface area is limited by the temperature rise due to self-heating. The proposed system uses a microchannel heat sink made of chemical-vapor-deposited (CVD) diamond, whose high thermal conductivity increases the efficiency of the channel-wall fins and reduces the array-to-coolant thermal resistance using a simple model for the combined conduction and convection problem. The resistance is calculated to be 75% less than that for a conventional configuration using a silicon microchannel heat sink. The present analysis strongly motivates a future experimental study.
A simple hybrid aligner for generating lexical correspondences in parallel texts (1998)

We present an algorithm for bilingual word alignment that extends previous work by treating multi-word candidates on a par with single words, and combining some simple assumptions about the translation process to capture alignments for low frequency words. As most other alignment algorithms it uses cooccurrence statistics as a basis, but differs in the assumptions it makes about the translation process. The algorithm has been implemented in a modular system that allows the user to experiment with different combinations and variants of these assumptions. We give performance results from two evaluations, which compare will with results reported in the literature.
Histone Deacetylase Inhibitors for Treating a Spectrum of Diseases Not Related to Cancer (2011)

This issue of Molecular Medicine contains 14 original research reports and state-of-the-art reviews on histone deacetylase inhibitors (HDACi's), which are being studied in models of a broad range of diseases not related to the proapoptotic properties used to treat cancer. The spectrum of these diseases responsive to HDACi's is for the most part due to several antiinflammatory properties, often observed in vitro but importantly also in animal models. One unifying property is a reduction in cytokine production as well as inhibition of cytokine postreceptor signaling. Distinct from their use in cancer, the reduction in inflammation by HDACi's is consistently observed at low concentrations compared with the higher concentrations required for killing tumor cells. This characteristic makes HDACi's attractive candidates for treating chronic diseases, since low doses are well tolerated. For example, low oral doses of the HDACi givinostat have been used in children to reduce arthritis and are well tolerated. In addition to the antiinflammatory properties, HDACi's have shown promise in models of neurodegenerative disorders, and HDACi's also hold promise to drive HIV-1 out of latently infected cells. No one molecular mechanism accounts for the non-cancer-related properties of HDACi's, since there are 18 genes coding for histone deacetylases. Rather, there are mechanisms unique for the pathological process of specific cell types. In this overview, we summarize the preclinical data on HDACi's for therapy in a wide spectrum of diseases unrelated to the treatment of cancer. The data suggest the use of HDACi's in treating autoimmune as well as chronic inflammatory diseases.
Evaluating preferences for profiles of glucagon-like peptide-1 receptor agonists among injection-naive type 2 diabetes patients in Japan (2016)

This study elicited the preferences of Japanese T2DM patients for attributes and levels representing the actual characteristics of two existing glucagon-like peptide-1 receptor agonists. In this comparison, dosing frequency and type of delivery system were the two most important characteristics, accounting for >70% of the RI. These findings are similar to those of a previous UK study, providing information about patients' preferences that may be informative for patient-clinician treatment discussions.
The Challenge of Change (1987)

There are ways to use the opportunity of change to better effect — to revitalise an organisation and give it advantages over its competitors. By confronting issues, action becomes imperative and unavoidable. Goals need to be clarified with clear time scales for their achievement. A change strategy can then be developed. By involving the people threatened by the changes in the planning of details, one reduces the feelings of threat and gains the employees' commitment. Avoid the pitfalls of too much haste, the overlooking of knock‐on effects to other systems and the failure to reinforce changes.
Efficacy of combinations of difluoromethylornithine and bleomycin in a mouse model of central nervous system African trypanosomiasis. (1983)

DL-alpha-Difluoromethylornithine, a polyamine biosynthesis inhibitor, and bleomycin, a currently used antineoplastic agent, have each previously been shown to be curative for acute short-term infections of mice with Trypanosoma brucei brucei, an African trypanosome closely related to those that cause the human disease African sleeping sickness. These agents were tested singly and in combination in a previously described mouse model of sleeping sickness with demonstrable brain involvement. The original model is extended by using two additional strains of outbred mice and by demonstrating that melarsoprol, an arsenical and currently the only drug used for human African trypanosomiasis involving the brain, was also curative for these brain infections. Neither difluoromethylornithine nor bleomycin alone was curative for the brain infections; however, many combinations of the two drugs were found to be 100% curative with no evidence of immediate toxicity.
Water-Soluble Nonconjugated Polymer Nanoparticles with Strong Fluorescence Emission for Selective and Sensitive Detection of Nitro-Explosive Picric Acid in Aqueous Medium (2016)

Water-soluble nonconjugated polymer nanoparticles (PNPs) with strong fluorescence emission were prepared from hyperbranched poly(ethylenimine) (PEI) and d-glucose via Schiff base reaction and self-assembly in aqueous phase. Preparation of the PEI-d-glucose (PEI-G) PNPs was facile (one-pot reaction) and environmentally friendly under mild conditions. Also, PEI-G PNPs showed a high fluorescence quantum yield in aqueous solution, and the fluorescence properties (such as concentration- and solvent-dependent fluorescence) and origin of intrinsic fluorescence were investigated and discussed. PEI-G PNPs were then used to develop a fluorescent probe for fast, selective, and sensitive detection of nitro-explosive picric acid (PA) in aqueous medium, because the fluorescence can be easily quenched by PA whereas other nitro-explosives and structurally similar compounds only caused negligible quenching. A wide linear range (0.05-70 μM) and a low detection limit (26 nM) were obtained. The fluorescence quenching mechanism was carefully explored, and it was due to a combined effect of electron transfer, resonance energy transfer, and inner filter effect between PA and PEI-G PNPs, which resulted in good selectivity and sensitivity for PA. Finally, the developed sensor was successfully applied to detection of PA in environmental water samples.
A Large-Margin Approach for Multi-Label Classification Based on Correlation Between Labels (2019)

Multi label classification is a challenging task in machine learning concerned with assigning a sample to a subset of available label set. Meaning, a sample can belong to multiple labels. Furthermore, high dimensionality of data and complex correlation between labels makes it even more interesting. For this reason, it attracted many researchers in recent years. classifier-chains (CC), one of well-known methods for multi label classification which is based on binary relevance (BR) method, incorporates label correlation by assuming an order for labels and inserting previous label outputs in feature space and achieves higher performance while still retaining relatively low time complexity. But using predicted labels as features might not be very interpretable with regards to integrating label correlation into the model, especially considering there could be different types of features in a dataset. In this paper, we propose an approach for using correlation among labels based on structure of CC by defining a large-margin model between two predicted labels. Thus directly exploiting the correlation between them in a more interpretable way. The proposed approach is evaluated using 9 multi label datasets and 2 evaluation metrics. Empirical experiments show promising results and demonstrate the effectiveness of proposed method against classifier chains algorithm.
Therapeutic polypeptides based on HBcAg<sub>18-27</sub>CTL epitope can induce antigen-specific CD<sub>8</sub><sup>+</sup>CTL-mediated cytotoxicity in HLA-A2 transgenic mice (2004)

A designed universal T helper plus B-epitopes with short and flexible linkers could dramatically improve the immunogenicity of CTL epitopes in vivo. And that the mimetic therapeutic peptides based on the reasonable match of the above CTL, B- and T helper epitopes could be a promising therapeutic peptide vaccine candidate against HBV infection.
Action research and system dynamics: can they benefit from each other? (2004)

Messy and ill-defined problems are at the center of studies both in action research and system dynamics. However, while action research is seen as a research method far out on the qualitative side of the spectrum, system dynamics seems to be equally far out on the quantitative side. Yet, both research methodologies employ iterative and spiral designs, which resemble each other in various phases. As in action research, practitioners have collaborated with researchers in system dynamics model building in pursuit of improving an organizational situation. The paper discusses the discrepancies, intersections, and complementarities of the two methods, and proposes the integration of system dynamics group model building into participatory action research.
ToTTo: A Controlled Table-To-Text Generation Dataset (2020)

Ankur Parikh, Xuezhi Wang, Sebastian Gehrmann, Manaal Faruqui, Bhuwan Dhingra, Diyi Yang, Dipanjan Das. Proceedings of the 2020 Conference on Empirical Methods in Natural Language Processing (EMNLP). 2020.
PHLOSOPHY OF RELIGION AND THEOLOGY (1971)

PHLOSOPHY OF RELIGION AND THEOLOGY A Variety of Catholic Modernists. By ALEX VIDLERCambridge Cambridge University Press, 1970. 232 pages. $8.50. BERNARD BRANDON SCOTT BERNARD BRANDON SCOTT St. Meinard School of Theology Search for other works by this author on: Oxford Academic Google Scholar Journal of the American Academy of Religion, Volume XXXIX, Issue 3, September 1971, Pages 395-b–396, https://doi.org/10.1093/jaarel/XXXIX.3.395-b Published: 01 September 1971
Propuesta de un modelo para promover la pertinencia cultural desde el currículo de educación preescolar en el Cantón de Turrialba (2011)

La creacion de un curriculo con pertinencia cultural desde la educacion inicial, permite rescatar en un mundo globalizado, la realidad historica-cultural de los estudiantes y las estudiantes, promoviendo la construccion de aprendizajes significativos, en un ambiente respetuoso de la diversidad y vinculado al contexto en que se desarrolla el proceso educativo, respondiendo de esa forma a las necesidades de la poblacion estudiantil.
Detection of Prion Protein Particles in Blood Plasma of Scrapie Infected Sheep (2012)

Prion diseases are transmissible neurodegenerative diseases affecting humans and animals. The agent of the disease is the prion consisting mainly, if not solely, of a misfolded and aggregated isoform of the host-encoded prion protein (PrP). Transmission of prions can occur naturally but also accidentally, e.g. by blood transfusion, which has raised serious concerns about blood product safety and emphasized the need for a reliable diagnostic test. In this report we present a method based on surface-FIDA (fluorescence intensity distribution analysis), that exploits the high state of molecular aggregation of PrP as an unequivocal diagnostic marker of the disease, and show that it can detect infection in blood. To prepare PrP aggregates from blood plasma we introduced a detergent and lipase treatment to separate PrP from blood lipophilic components. Prion protein aggregates were subsequently precipitated by phosphotungstic acid, immobilized on a glass surface by covalently bound capture antibodies, and finally labeled with fluorescent antibody probes. Individual PrP aggregates were visualized by laser scanning microscopy where signal intensity was proportional to aggregate size. After signal processing to remove the background from low fluorescence particles, fluorescence intensities of all remaining PrP particles were summed. We detected PrP aggregates in plasma samples from six out of ten scrapie-positive sheep with no false positives from uninfected sheep. Applying simultaneous intensity and size discrimination, ten out of ten samples from scrapie sheep could be differentiated from uninfected sheep. The implications for ante mortem diagnosis of prion diseases are discussed.
[Effects of ginsenoside-Rb on blood lipid metabolism and anti-oxidation in hyperlipidemia rats]. (2004)

To observe effects of ginsenoside-Rb (G-Rb) on total cholesterol, lipoprotein cholesterol metabolism and anti-oxidation in experimental hyperlipidemia rats.Hyperlipidemia rats were respectively given G-Rb 50, 100, 200 mg x kg(-1) x d(-1) ig for twelve days. Total cholesterol, lipoprotein cholesterol and lipid peroxidation (LPO) contents, prostacycline (PGI2), thromboxane (TXA2), superoxide dismutase (SOD) and blood viscosity were measured. Fat accumulation in liver was also observed.Triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-c) in serum, TXA2 in plasma, LPO in serum and liver, and blood viscosity were decreased significantly. High density lipoprotein cholesterol (HDLc) in serum, PGI2 in plasma and SOD in serum and liver were significantly increased by G-Rb (100, 200 mg x kg(-1)) in experimental hyperlipidemia rats. In addition, G-Rb could decrease TC/HDL-c, LDLc/HDL-c ratio, increase PGI2/TXA2 ratio and inhibit fat accumulation in liver.G-Rb could have anti-arteriosclerosis effect by improving cholesterol and lipoprotein-cholesterol metabolism, suppressing lipid peroxidation, increasing anti-oxidase activity and PGI2/TXA2 ratio.
Highly magnetic silica-coated iron nanoparticles prepared by the arc-discharge method (2006)

In spite of encouraging progress in recent years, the development of magnetic nanoparticles that can be used as drug delivery vectors remains a significant challenge for materials scientists. Among the multiple hurdles that must be overcome are the provision of a sufficiently high magnetic response, a high loading capacity for therapeutic or diagnosis materials and a sufficient degree of biocompatibility. In this work we describe the preparation of encapsulated magnetic nanoparticles consisting of a metallic iron core and an amorphous silica shell by using a modification of the arc-discharge method. This is a simple and inexpensive way to produce well-coated iron nanoparticles. The particles thus obtained present a much stronger magnetic response than any composite material produced up to now involving magnetic nanoparticles encapsulated in inorganic matrices, and the rich chemistry and easy functionalization of the silica outer surface make them promising materials for their application as magnetic carriers.
Olfactory thresholds for androstenone and Galaxolide: sensitivity, insensitivity and specific anosmia (1993)

Journal Article Olfactory thresholds for androstenone and Galaxolide: sensitivity, insensitivity and specific anosmia Get access Ahmet Baydar, Ahmet Baydar 1 Givaudan-Roure, Centre de Recherche34 chemin de la Madeleine, BP 72, 06332 Grasse CEDEX, France 1To whom correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar Martin Petrzilka, Martin Petrzilka Givaudan-Roure, Centre de Recherche34 chemin de la Madeleine, BP 72, 06332 Grasse CEDEX, France Search for other works by this author on: Oxford Academic PubMed Google Scholar Marie-Pierre Schott Marie-Pierre Schott Givaudan-Roure, Centre de Recherche34 chemin de la Madeleine, BP 72, 06332 Grasse CEDEX, France Search for other works by this author on: Oxford Academic PubMed Google Scholar Chemical Senses, Volume 18, Issue 6, December 1993, Pages 661–668, https://doi.org/10.1093/chemse/18.6.661 Published: 01 December 1993 Article history Received: 11 August 1992 Accepted: 16 September 1993 Published: 01 December 1993
Benzimidazole chemistry. I. Syntheses of the three N-propyl isomers of 4-amino-2,6-dimethylbenzimidazole (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBenzimidazole chemistry. I. Syntheses of the three N-propyl isomers of 4-amino-2,6-dimethylbenzimidazoleRobert E. Lyle and John L. LaMattinaCite this: J. Org. Chem. 1975, 40, 4, 438–441Publication Date (Print):February 1, 1975Publication History Published online1 May 2002Published inissue 1 February 1975https://pubs.acs.org/doi/10.1021/jo00892a012https://doi.org/10.1021/jo00892a012research-articleACS PublicationsRequest reuse permissionsArticle Views322Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
DESIGNING MPEG-4 FACIAL ANIMATION TABLES FOR WEB APPLICATIONS (2001)

The Internet today already uses a lot of text, pictures, videos, animations, etc. to attract the user attention. Considerable advancement in this direction can be achieved by improving the interactivity with the user. In this article, we expose different methods for designing facial models and to make them interactive based on MPEG-4 facial animation parameters. We explain the integration of the web version of our MPEG-4 Facial Animation system in an applet towards making the web pages not only attractive but also interactive.
Persistent inflammation alters the function of the endogenous brain stem cell compartment (2008)

Endogenous neural stem/precursor cells (NPCs) are considered a functional reservoir for promoting tissue homeostasis and repair after injury, therefore regenerative strategies that mobilize these cells have recently been proposed. Despite evidence of increased neurogenesis upon acute inflammatory insults (e.g. ischaemic stroke), the plasticity of the endogenous brain stem cell compartment in chronic CNS inflammatory disorders remains poorly characterized. Here we show that persistent brain inflammation, induced by immune cells targeting myelin, extensively alters the proliferative and migratory properties of subventricular zone (SVZ)-resident NPCs in vivo leading to significant accumulation of non-migratory neuroblasts within the SVZ germinal niche. In parallel, we demonstrate a quantitative reduction of the putative brain stem cells proliferation in the SVZ during persistent brain inflammation, which is completely reversed after in vitro culture of the isolated NPCs. Together, these data indicate that the inflamed brain microenvironment sustains a non cell-autonomous dysfunction of the endogenous CNS stem cell compartment and challenge the potential efficacy of proposed therapies aimed at mobilizing endogenous precursors in chronic inflammatory brain disorders.
논문 : 식품 포장재에 대한 가식성 필름의 응용성에 관한 연구 (1999)

본 실험은 라면 스프 포장재에 대한 가식성 필름의 응용성을 조사하였다. 기본 실험으로서는 라면 스프의 등온흡습곡선 및 BET 단분자막 수분함량을 조사하였으며, 응용성 실험으로서는 가식성 필름의 인장강도, 신장률, 수분 투과도 및 용해도를 대하여 조사하였다. 가식성 필름으로서는 methylcellulose, sodium caseinate 및 K-carrageenan을 사용하였으며, 가소제로서는 glycerol과 polyethylene glycol (MW 400)을 사용하였다. 인장강도의 경우, methylcellulose 필름의 수치가 68.56 MPa로 가장 크게 나타났으며, sodium caseinate 필름이 가장 낮은 수치인 7.11 MPa로 나타났다. 신장률에 대한 실험 결과, sodium caseinate 필름이 가장 높은 수치인 115.41 %를 나타냈으며, methylcellulose 및 K-carrageenan 필름은 각각 23.79% 및 0.60%로 나타났다. 상대습도 50% - 70%사이에서 methylcellulose와 sodium caseinate 및 K-carrageenan 필름의 측정된 수분 투과도 값의 범위는 각각 $0.25-0.38ng\;m/m^2{\cdot}sec{\cdot}Pa$ 와 $0.62-0.84ng{\cdot}m/m^2{\cdot}sec{\cdot}Pa$ 및 $0.31-0.55ng{\cdot}m/m^2{\cdot}sec{\cdot}Pa$ 로 나타났다. 가식성 필름의 용해도에 대해서는 sodium caseinate film의 경우 뜨거운 물에 대한 높은 용해성을 나타내어 5초 이내에 이 필름은 물에 용해되었으며, K-carrageenan film은 높은 팽윤율을 나타내어 150초 이후에 필름의 붕괴 현상이 일어났다. Methylcellulose film의 경우는 물에 대한 용해도가 떨어지는 것으로 나타났다. 【This study was conducted to investigate the application of edible films to Raymyun soup packaging. The sorption isotherm curve and BET monolayer moisture content of Raymyun soup were estimated as a basic experiment. Also, the mechanical properties, water vapor permeability, and solubility of the films were investigated. Methylcellulose, sodium caseinate, and K-carrageenan films were used as edible films and glycerol and polyethylene glycol(MW 400) were used as plasticizers. In case tensile strength, methylcellulose films was 68.56 MPa and sodium caseinate film was 7.11 MPa. The elongations of sodium caseinate, methylcellulose, and K-carrageenan film were 115.41%, 23.79% and 0.60%, respectively. The water vapor permeabilties values of methylcellulose, sodium caseinate, and K-carrageenan film between 50% and 70% RH were $0.25-0.38ng{\cdot}m/m^2{\cdot}sec{\cdot}Pa,\;0.62-0.84ng{\cdot}m/m^2{\cdot}sec{\cdot}Pa\;and\;0.31-0.55ng{\cdot}m/m^2{\cdot}sec{\cdot}Pa$ , respectively. For the solubility of films, sodium caseinate film showed the highest solubility and methylcellulose film showed the lowest solubility.】
Disproportionality as a Framework to Target Pollution Reduction from Urban Landscapes (2008)

New federal water quality regulations regarding impaired waters and urban stormwater alongside a growing need to reverse eutrophication of urban lakes are creating demand to decrease nutrient export from urban landscapes, particularly lawns. We propose that Nowak's disproportionality framework could be used to target specific households likely to generate disproportionate levels of nutrient export. The biophysical dimension would be based on landscape vulnerability (slope; soil type; proximity to lakes); the social dimension would target "inappropriate" lawn management behaviors leading to high nutrient export on these vulnerable landscapes. Understanding of lawn nutrient cycling (biophysical dimension) and homeowner beliefs and attitudes (social dimension) would be used to develop targeted, specific messages for homeowners with inappropriate management practices. A lawn management program developed with this disproportionality framework would probably be very effective, highly economical and fair, targeting only homeowners who are creating a disproportionate impact.
[An investigation of medicinal Trichosanthes]. (1995)

This paper reports the distribution, habitats and medical usages of 14 species of medicinal Trichosanthes produced in China. Among them, there is a new species named Trichosanthes mianyangensis. A key for the identification of all these 14 species has been compiled and presented.