gebhart/patrepeval huggingface dataset:
Overview of latest work on perpendicular recording media (2000)

Recent works on perpendicular recording media were reviewed, Co-Cr alloy films are still under improvment and show a recording ability of 20 Gbit/in/sup 2/ and beyond. New perpendicular recording media that have high perpendicular anisotropy have been developed. These would be candidate media for ultrahigh density recording beyond 100 Gbit/in/sup 2/.
Contact-Type Linear Sensor Using Amorphous Si Diode Array (1983)

A contact-type linear sensor using amorphous Si diodes as photodetectors has been developed. The sensor structure can largely reduce the number of electrodes to be connected to the switching FETs and hence has an advantage of realizing a facsimile reader which is compact and easy to construct. The linear sensor developed is constructed with 256 pairs of In 2 O 3 /a-Si photodiodes and Pt/a-Si blocking diodes and this combination of two types of diodes has been found to yield high output signal. In this sensor structure, incident light is introduced to the photodiodes through a glass substrate in order to protect the photodetectors from contamination and scratching.
Thermodynamic Properties of the Intermetallic Systems Lithium‐Antimony and Lithium‐Bismuth (1978)

Galvanic cells of the type , were employed to determine the Gibbs free energy of formation , and the corresponding enthalpies , and entropies for the systems Li‐Sb and Li‐Bi as a function of composition from pure to the Li‐rich side of the phases. The Li/X ratio was changed systematically by use of the coulometric titration technique. values were obtained by integration of the coulometric titration curve from pure to the composition of interest. Thermodynamic data have been determined for the trilithium compounds as a function of the stoichiometry. and were calculated from the temperature dependence of . Data were obtained over the temperature range 355°–600°C. At 400°C the following values were found for the standard Gibbs free energy of formation: , , , and , all ±0.1 kJ mole−1. The standard enthalpies of formation are: ,, , , all ±0.7 kJ mole−1. The standard entropies of formation are: , , , and, all ±1 J mole−1K−1. The experimental results were also used to examine the phase diagrams for Li‐Sb and Li‐Bi. The range of stoichiometry of is very narrow , whereas exhibits a large deviation from the ideal stoichiometry , predominantly on the lithium‐deficit side. and have been found to be the only intermediate phases existing beside the trilithium phases in the temperature range investigated.
Anteromedial Portal Technique for Creating the Anterior Cruciate Ligament Femoral Tunnel (2007)

There has been a renewed focus on anterior cruciate ligament (ACL) insertional anatomy and its biomechanics. It has been postulated that traditional single-bundle transtibial reconstructions have placed grafts in a less anatomic location relative to the true ACL insertion site. In traditional transtibial techniques, the femoral tunnel is predetermined by the position of the tibial tunnel. It is our belief that achieving the most anatomic position for the graft requires the femoral and tibial tunnels to be drilled independently. Use of the anteromedial portal technique provides us with more flexibility in accurately placing the femoral tunnel in the true ACL insertion site as compared with the transtibial technique. Advantages include anatomic tunnel placement, easy preservation of any remaining ACL fibers when performing ACL augmentation procedures, and flexibility in performing either single- or double-bundle reconstructions in primary or revision settings. This technique is not limited by the choice of graft or fixation and offers the advantage of true parallel screw placement through the same portal as that used for tunnel drilling in the case of interference fixation.
Wounding of Arabidopsis leaves induces indole‐3‐carbinol‐dependent autophagy in roots of <i>Arabidopsis thaliana</i> (2017)

In cruciferous plants insect attack or physical damage induce the synthesis of the glucosinolate breakdown product indole-3-carbinol, which plays a key role in the defense against attackers. Indole-3-carbinol also affects plant growth and development, acting as an auxin antagonist by binding to the TIR1 auxin receptor. Other potential functions of indole-3-carbinol and the underlying mechanisms in plant biology are unknown. Here we show that an indole-3-carbinol-dependent signal induces specific autophagy in root cells. Leaf treatment with exogenous indole-3-carbinol or leaf-wounding induced autophagy and inhibited auxin response in the root. This induction is lost in glucosinolate-defective mutants, indicating that the effect of indole-3-carbinol is transported in the plants. Thus, indole-3-carbinol is not only a defensive metabolite that repels insects, but is also involved in long-distance communication regulating growth and development in plants.
Development of viral nanoparticles for efficient intracellular delivery (2012)

Viral nanoparticles (VNPs) based on plant viruses such as Cowpea mosaic virus (CPMV) can be used for a broad range of biomedical applications because they present a robust scaffold that allows functionalization by chemical conjugation and genetic modification, thereby offering an efficient drug delivery platform that can target specific cells and tissues. VNPs such as CPMV show natural affinity to cells; however, cellular uptake is inefficient. Here we show that chemical modification of the CPMV surface with a highly reactive, specific and UV-traceable hydrazone linker allows bioconjugation of polyarginine (R5) cell penetrating peptides (CPPs), which can overcome these limitations. The resulting CPMV-R5 particles were taken up into a human cervical cancer cell line (HeLa) more efficiently than native particles. Uptake efficiency was dependent on the density of R5 peptides on the surface of the VNP; particles displaying 40 R5 peptides per CPMV (denoted as CPMV-R5H) interact strongly with the plasma membrane and are taken up into the cells via an energy-dependent mechanism whereas particles displaying 10 R5 peptides per CPMV (CPMV-R5L) are only slowly taken up. The fate of CPMV-R5 versus native CPMV particles within cells was evaluated in a co-localization time course study. It was indicated that the intracellular localization of CPMV-R5 and CPMV differs; CPMV remains trapped in Lamp-1 positive endolysosomes over long time frames; in contrast, 30-50% of the CPMV-R5 particles transitioned from the endosome into other cellular vesicles or compartments. Our data provide the groundwork for the development of efficient drug delivery formulations based on CPMV-R5.
Transformation and Release to the Gas Phase of Cl, K, and S during Combustion of Annual Biomass (2004)

The transformation of inorganic constituents in annual biomass was experimentally investigated at grate-combustion conditions. A laboratory fixed-bed reactor was applied to obtain quantitative information of the release of Cl, K, and S to the gas phase from six distinctively different annual biomass fuels. Samples of 4.0 g of biomass were combusted at well-controlled conditions at temperatures from 500 to 1150 °C. The elemental release was quantified by analysis of the residual ash and a mass balance on the system. The experimental results revealed that potassium was released to the gas phase in significant amounts at combustion above 700 °C. The potassium release increased with the applied combustion temperature for all biomass fuels; however, the quantity released was largely determined by the ash composition. At 1150 °C, between 50 and 90% of the total potassium was released to the gas phase. The biomass fuels with an appreciable content of silicate showed the lower release of potassium. Between 25 and 70% of the fuel chlorine was released below 500 °C; the residual chlorine was released by evaporation of KCl, mainly between 700 and 800 °C. Above 800 °C, the fuel chlorine was completely released to the gas phase for all of the samples. Between 30 and 55% of the fuel sulfur was released at 500 °C. The samples rich in K and Ca, but low in Si, displayed only a minor increase in the sulfur release as the combustion temperature was further increased. On the contrary, the sulfur release increased abruptly above 700−800 °C for the Si-rich samples. On the basis of the release quantification, the overall transformations of the ash-forming elements are discussed at grate-combustion conditions.
Postural Sway and Gaze Can Track the Complex Motion of a Visual Target (2015)

Variability is an inherent and important feature of human movement. This variability has form exhibiting a chaotic structure. Visual feedback training using regular predictive visual target motions does not take into account this essential characteristic of the human movement, and may result in task specific learning and loss of visuo-motor adaptability. In this study, we asked how well healthy young adults can track visual target cues of varying degree of complexity during whole-body swaying in the Anterior-Posterior (AP) and Medio-Lateral (ML) direction. Participants were asked to track three visual target motions: a complex (Lorenz attractor), a noise (brown) and a periodic (sine) moving target while receiving online visual feedback about their performance. Postural sway, gaze and target motion were synchronously recorded and the degree of force-target and gaze-target coupling was quantified using spectral coherence and Cross-Approximate entropy. Analysis revealed that both force-target and gaze-target coupling was sensitive to the complexity of the visual stimuli motions. Postural sway showed a higher degree of coherence with the Lorenz attractor than the brown noise or sinusoidal stimulus motion. Similarly, gaze was more synchronous with the Lorenz attractor than the brown noise and sinusoidal stimulus motion. These results were similar regardless of whether tracking was performed in the AP or ML direction. Based on the theoretical model of optimal movement variability tracking of a complex signal may provide a better stimulus to improve visuo-motor adaptation and learning in postural control.
CHROMOSOME STABILITY IN MAIZE (<i>ZEA MAYS</i>) TISSUE CULTURES AND SECTORING IN SOME REGENERATED PLANTS (1982)

Cytogenetic stability of maize (Zea mays L.) tissue cultures was assessed by meiotic analysis of plants regenerated from 4- and 8-month-old tissue cultures and by mitotic analysis of cultured cells 4 and 8 months after culture initiation. Cultures initiated from four embryos each of W22 R-nj R-nj × A188 and A188 × W22 R-nj R-nj were examined. After four months in culture, only one of 65 regenerated plants was abnormal; after eight months, only four of 59 regenerated plants were abnormal. Three of the five abnormal plants had normal and cytogenetically abnormal sectors in the tassels. Inheritance studies were conducted on 51 regenerated plants. Eight plants segregated in the S 1 for recessive mutations resulting in defective kernels, and one plant segregated for a recessive mutation resulting in a wilted phenotype. Eight different plants that produced normal S 1 progeny segregated for defective kernel mutations in some S 1 families, indicating a lack of concordance between male and female reproductive cells in the original regenerated plant. The cytogenetic stability observed in regenerated plants also was observed in vitro, indicating that selection at the time of regeneration did not occur. Four hundred and thirty-four (97%) of the 449 cells analyzed in 4-month-old cultures had the normal 20-chromosome complement; 377 (95%) of the 398 cells analyzed in 8-month-old cultures were normal. These results indicate that chromosome stability is maintained in tissue cultures of A188 × W22 R-nj R-nj maize.
Immobilization and Intracellular Delivery of an Anticancer Drug Using Mussel-Inspired Polydopamine Capsules (2012)

We report a facile approach to immobilize pH-cleavable polymer-drug conjugates in mussel-inspired polydopamine (PDA) capsules for intracellular drug delivery. Our design takes advantage of the facile PDA coating to form capsules, the chemical reactivity of PDA films, and the acid-labile groups in polymer side chains for sustained pH-induced drug release. The anticancer drug doxorubicin (Dox) was conjugated to thiolated poly(methacrylic acid) (PMA(SH)) with a pH-cleavable hydrazone bond, and then immobilized in PDA capsules via robust thiol-catechol reactions between the polymer-drug conjugate and capsule walls. The loaded Dox showed limited release at physiological pH but significant release (over 85%) at endosomal/lysosomal pH. Cell viability assays showed that Dox-loaded PDA capsules enhanced the efficacy of eradicating HeLa cancer cells compared with free drug under the same assay conditions. The reported method provides a new platform for the application of stimuli-responsive PDA capsules as drug delivery systems.
Enantioselective Pd-Catalyzed Allylation Reaction of Fluorinated Silyl Enol Ethers (2007)

An enantioselective Pd-catalyzed allylation reaction of fluorinated silyl enol ethers is reported. This reaction provides a stereoselective and efficient approach to allylated tertiary α-fluoroketones from achiral fluorinated precursors. A variety of cyclic silyl enol ether can be used, and the yields of the desired products range from 52 to 93%, and the enantiomeric excesses range from 83 to 95% ee.
HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53 (2003)

The RING finger proteins HdmX and Hdm2 share significant structural and functional similarity. Hdm2 is a member of the RING finger family of ubiquitin-protein ligases E3 and targets the tumor suppressor protein p53 for degradation. Although HdmX also binds to p53, HdmX does not induce p53 degradation. Moreover, HdmX has been reported to interfere with p53 degradation in overexpression experiments. To obtain insight into the mechanism by which HdmX interferes with p53 degradation, we studied the effect of HdmX on the E3 activity of Hdm2 in vitro. Surprisingly, this revealed that HdmX stimulates Hdm2-mediated ubiquitination of p53 and that HdmX facilitates ubiquitination of Hdm2 and vice versa. In addition, down-regulation of HdmX expression within cells results in the accumulation of both p53 and Hdm2. Because HdmX alone does not have appreciable E3 activity, these data indicate that HdmX acts as a stimulator, rather than as an inhibitor, of the E3 activity of Hdm2 and that, at least under certain conditions, HdmX is actively involved in the degradation of both p53 and Hdm2.
Table Lookup Structures for Multiplicative Inverses Modulo 2^k (2005)

We introduce an inheritance property and related table lookup structures applicable to simplified evaluation of the modular operations "multiplicative inverse", "discrete log", and "exponential residue" in the particular modulus 2/sup k/. Regarding applications, we describe an integer representation system of Benschop for transforming integer multiplications into additions which benefits from our table lookup function evaluation procedures. We focus herein on the multiplicative inverse modulo 2/sup k/ to exhibit simplifications in hardware implementations realized from the inheritance property. A table lookup structure given by a bit string that can be interpreted with reference to a binary tree is described and analyzed. Using observed symmetries, the lookup structure size is reduced allowing a novel direct lookup process for multiplicative inverses for all 16-bit odd integers to be obtained from a table of size less than two KBytes. The 16-bit multiplicative inverse operation is also applicable for providing a seed inverse for obtaining 32/64-bit multiplicative inverses by one/two iterations of a known quadratic refinement algorithm.
Feature Dimensionality Reduction Through Genetic Algorithms For Faster Speaker Recognition (2008)

Publication in the conference proceedings of EUSIPCO, Lausanne, Switzerland, 2008
Injury-activated glial cells promote wound healing of the adult skin in mice (2018)

Cutaneous wound healing is a complex process that aims to re-establish the original structure of the skin and its functions. Among other disorders, peripheral neuropathies are known to severely impair wound healing capabilities of the skin, revealing the importance of skin innervation for proper repair. Here, we report that peripheral glia are crucially involved in this process. Using a mouse model of wound healing, combined with in vivo fate mapping, we show that injury activates peripheral glia by promoting de-differentiation, cell-cycle re-entry and dissemination of the cells into the wound bed. Moreover, injury-activated glia upregulate the expression of many secreted factors previously associated with wound healing and promote myofibroblast differentiation by paracrine modulation of TGF-β signalling. Accordingly, depletion of these cells impairs epithelial proliferation and wound closure through contraction, while their expansion promotes myofibroblast formation. Thus, injury-activated glia and/or their secretome might have therapeutic potential in human wound healing disorders.
Conception and feasibility of bamboo–precocious wood composite beams (2003)

Founded in 1683 in Leiden, the Netherlands, Brill is a leading international academic publisher in the Humanities, Social Sciences, International Law, and Biology. With offices in the Netherlands, Germany, Austria, the USA and Asia, Brill today publishes more than 360 journals and 2,000 new books and reference works each year as well as a large number of databases and primary source research collections.
Epidemiology of Burkholderia cepacia complex species recovered from cystic fibrosis patients: issues related to patient segregation (2004)

Studies of the prevalence of Burkholderia cepacia complex species amongst cystic fibrosis (CF) patients in different geographical regions, and the association between cross-infection and putative transmissibility markers, will further our understanding of these organisms and help to address infection-control issues. In this study, B. cepacia complex isolates from CF patients in different regions of Europe were analysed. Isolates were examined for B. cepacia complex species and putative transmissibility markers [cable pilin subunit gene (cblA) and the B. cepacia epidemic strain marker (BCESM)]. Sporadic and cross-infective strains were identified by random amplification of polymorphic DNA (RAPD). In total, 79% of patients were infected with Burkholderia cenocepacia (genomovar III), 18% with Burkholderia multivorans (genomovar II) and less than 5% of patients with B. cepacia (genomovar I), Burkholderia stabilis (genomovar IV) or Burkholderia vietnamiensis (genomovar V). The cblA and BCESM transmissibility markers were only detected in strains of B. cenocepacia. The BCESM was a more sensitive marker for transmissible B. cenocepacia strains than cblA, although sporadic B. cenocepacia strains containing the BCESM, but lacking cblA, were also observed. Furthermore, clusters of cross-infection with transmissibility marker-negative strains of B. multivorans were identified. In conclusion, B. cenocepacia was the greatest cause of cross-infection, and the most widely distributed B. cepacia complex species, within these CF populations. However, cross-infection was not exclusive to B. cenocepacia and cblA and the BCESM were not absolute markers for transmissible B. cenocepacia, or other B. cepacia complex strains. It is therefore suggested that CF centres cohort patients based on the presence or absence of B. cepacia complex infection and not on the basis of transmissibility marker-positive B. cenocepacia as previously suggested.
Suppression of proliferation and oxidative stress by extracts of Ganoderma lucidum in the ovarian cancer cell line OVCAR-3 (2011)

Lingzhi (LZ) is a medical mushroom also known as Ganoderma lucidum, which has been used in traditional Chinese medicine for more than 4,000 years and moreover, due to its presumed health benefits and apparent absence of side-effects it has also been widely consumed as a dietary supplement by cancer patients and by individuals diagnosed with various chronic diseases. The reported benefits of Ganoderma lucidum may be largely ascribed to its biologically active constituent polysaccharides and triterpenes known as ganoderic acids having structural similarity to steroid hormones. Laboratory studies have shown that Ganoderma lucidum enhances immune functions and also inhibits growth of various cancer cells both in vitro and in vivo. However, the mechanism by which Ganoderma lucidum exerts its chemopreventive activities remains unknown. In this study, we investigated whether Ganoderma lucidum elicits its anti-tumor effects by suppressing cell growth and inducing antioxidative/detoxification activity in human ovarian OVCAR-3 cells. The results showed that Ganoderma lucidum inhibits cell growth and disruption of cell cycle progression via down regulation of cyclin D1. Chemopreventive activities elicited by Ganoderma lucidum were demonstrated by the induction of antioxidant SOD and catalase as well as the phase II detoxification enzyme NAD(P)H:quinone oxidoreductase 1 (NQO1) and glutathione S-transferase P1 (GSTP1) via the Nrf2 mediated signaling pathway known to provide chemoprotection against carcinogenicity. These findings indicate that Ganoderma lucidum possesses chemopreventive potential contributing to its overall health effects and further suggest that Ganoderma lucidum may have clinical applications as an adjunct supplementary agent in chemotherapy.
Structure‐dependent functional properties of human defensin 5 (2007)

The mucosal epithelium secretes a variety of antimicrobial peptides that act as part of the innate immune system to protect against invading microbes. Here, we describe the functional properties of human defensin (HD) 5, the major antimicrobial peptide produced by Paneth cells in the ileum, in relation to its structure. The antimicrobial activity of HD-5 against Escherichia coli proved to be independent of its structure, whereas the unstructured peptide showed greatly reduced antimicrobial activity against Staphylococcus aureus. We find that HD-5 binds to the cell membrane of intestinal epithelial cells and induced secretion of the chemokine interleukin (IL)-8 in a concentration- and structure-dependent fashion. Incubation of HD-5 in the presence of tumor necrosis factor alpha further increased IL-8 secretion synergistically, suggesting that HD-5 may act as a regulator of the intestinal inflammatory response.
Large-scale ATM multistage switching network with shared buffer memory switches (1991)

The configuration of an asynchronous transfer mode (ATM) switch architecture using a shared buffer memory switch (SBMS) is discussed. The scaling factors of the ATM switching network under a condition of mixed applications, including a conventional mix and telecommunication with video, are analyzed. The use of the SBMS as the unit switch for a multistage switching network is examined. A prototype system and its performance evaluation and experimental data are presented. The data indicate excellent performance under a burst cell arrival condition. The buffer size of the SBMS can be reduced in comparison with that of an individual (nonshared) buffer memory switch. A configuration for a large-scale ATM switching network with multistage switches is proposed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
On training sample size and complexity of artificial neural net classifier (1992)

Small training sample effects common in sta.tistical·classmca.­ tion and artificial neural network classifier design are cliscussed. A review of known small sample results are presented, and peaking phenomena. related to the increase in the number of features and the number of neurons is discussed.
Efficiently Ranking Hyphotheses in Machine Learning (1997)

This paper considers the problem of learning the ranking of a set of alternatives based upon incomplete information (e.g. a limited number of observations). At each decision cycle, the system can output a complete ordering on the hypotheses or decide to gather additional information (e.g. observation) at some cost.