gebhart/patrepeval huggingface dataset:
Reproductive hormonal profiles of endurance-trained and untrained males (1988)

This study compares the resting reproductive hormonal profiles of untrained (N = 11) and endurance-trained (N = 11) males. Testosterone, free testosterone, estradiol, luteinizing hormone (LH), prolactin, and cortisol were measured by radioimmunoassay in resting blood samples (8 h fast) collected every 60 min for 4 h. The endurance-trained group had been active for (mean +/- SE) 12.4 +/- 6.7 yr, 6.6 +/- 0.2 d.wk-1, 68.5 +/- 4.4 min.d-1, while the untrained group was sedentary. Neither group had histories of hypothalamic-pituitary-testicular disorders. The overall 4 h mean testosterone and free testosterone levels were significantly (P less than 0.05) lower in the trained group (4.99 +/- 0.46 vs 7.25 +/- 0.67 ng.ml-1, and 17.2 +/- 1.4 vs 23.6 +/- 0.6 pg.ml-1, for the trained and untrained groups, respectively). The LH of the endurance-trained group was higher (15.3 +/- 1.9 vs 11.7 +/- 1.2 mIU.ml-1, P = 0.06); however, LH pulse frequency and amplitude did not differ between groups. An enhanced estradiol feedback to the hypothalamus-pituitary could not account for the elevated LH, as estradiol levels were similar in the groups. Prolactin and cortisol levels were normal and did not differ between groups. The results suggested normal hypothalamic-pituitary function existed in the trained subjects, and prolactin and cortisol were not causative factors in the lowered resting testosterone and free testosterone levels. The findings indicate that chronic endurance training lowers testosterone and free testosterone in males possibly by impairing testicular function.
Limits for Resolving Isobaric Tandem Mass Tag Reporter Ions Using Phase-Constrained Spectrum Deconvolution (2018)

A popular method for peptide quantification relies on isobaric labeling such as tandem mass tags (TMT), which enables multiplexed proteome analyses. Quantification is achieved by reporter ions generated by fragmentation in a tandem mass spectrometer. However, with higher degrees of multiplexing, the smaller mass differences between the reporter ions increase the mass resolving power requirements. This contrasts with faster peptide sequencing capabilities enabled by lowered mass resolution on Orbitrap instruments. It is therefore important to determine the mass resolution limits for highly multiplexed quantification when maximizing proteome depth. Here, we defined the lower boundaries for resolving TMT reporter ions with 0.0063 Da mass differences using an ultra-high-field Orbitrap mass spectrometer. We found the optimal method depends on the relative ratio between closely spaced reporter ions and that 64 ms transient acquisition time provided sufficient resolving power for separating TMT reporter ions with absolute ratio changes up to 16-fold. Furthermore, a 32 ms transient processed with phase-constrained spectrum deconvolution provides >50% more identifications with >99% quantified but with a slight loss in quantification precision and accuracy. These findings should guide decisions on what Orbitrap resolution settings to use in future proteomics experiments, relying on isobaric TMT reporter ion quantification.
Singlet Oxygen-Induced Photodegradation of the Polymers and Dyes in Optical Sensing Materials and the Effect of Stabilizers on These Processes (2013)

A comprehensive study of photodegradation processes in optical sensing materials caused by photosensitized singlet oxygen in different polymers is presented. The stabilities of the polymers are accessed in the oxygen consumption measurements performed with help of optical oxygen sensors. Polystyrene and poly(phenylsilesquioxane) are found to be the most stable among the polymers investigated, whereas poly(2,6-dimethyl-p-phenylene oxide) and particularly poly(methyl methacrylate) and their derivatives show the fastest oxygen consumption. The effect of the stabilizers (singlet oxygen quenchers) on the oxygen consumption rates, the photostability of the sensitizer, and the total photon emission (TPE) by singlet oxygen is studied. 1,4-Diazabicyclo[2.2.2]octane (DABCO) was found to significantly reduce both the TPE and the oxygen consumption rates, indicating its role as a physical quencher of singlet oxygen. The addition of DABCO also significantly improved the photostability of the sensitizer. The N-alkylated derivative of DABCO and DABCO covalently grafted to the polystyrene backbone are prepared in an attempt to overcome the volatility and water solubility of the quencher. These derivatives as well as other tertiary amines investigated were found to be inefficient as stabilizing agents, and some of them even negatively affected the oxygen consumption rates.
Expression and regulation of human and rat phosphodiesterase type IV isogenes (1994)

Type IV phosphodiesterases (PDE IV) specifically hydrolyze cAMP and are inhibited by rolipram. RT-PCR was applied to analyze the expression patterns of mRNAs for four cloned human and rat phosphodiesterase type IV isogenes (PDE IV-A, -B, -C and -D). Although these patterns were mostly coincident for the human and rat PDE IV genes, some differences were found between the two species. PDE IV-A expression was detectable in human blood but not in rat blood, suggesting a species-specific difference in the expression of this PDE IV isogene. PDE IV-C was neither detected in human or rat blood nor in different cell populations of the human immune system. It is further demonstrated that the PDE IV isogene expression is differentially regulated by cAMP in different cell types.
Non-ionic surfactant based organogels incorporating niosomes (1996)

Un nouvel organogel anhydre a ete mis au point a partir d 'une solution de deux surfactifs non ioniques, le monostearate de sorbitane (Span 60) et le monolaurate de sorbitane polyoxyethylene (Tween 20), realisee a 60°C dans l'hexadecane, qui se transforme par refroidissement en un gel thermoreversible semi-solide blanc. A l'examen microscopique, il apparait que ce dernier comporte des agglomerats de tubules et fibres disperses dans le milieu organique. L'addition a 60°C d'une phase aqueuse (eau ou suspension de niosomes) jusqu'a 17% v/v a la phase huileuse entraine la formation de systemes eau dans l'huile (e/h) ou vesicules dans l'eau dans l'huile (v/e/h), selon la nature de la phase aqueuse employee. Au refroidissement, la phase huileuse de ces emulsions gelifie : des bâtonnets et des fibres de surfactifs et quelques gouttelettes deformees sont observes. La vitesse de liberation du solute hydrophile a partir de ces gels est plus faible avec un systeme disperse (gouttelettes d'eau dans la phase continue aqueuse) forme a haute temperature qu'avec un gel dans lequel les structures apparentes des fibres forment des canaux continus a travers le milieu organique, offrant ainsi une possibilite de passage a la phase huileuse.
Antioxidant Activities of Dihydric Phenol Derivatives for the Autoxidation of Tetralin (1995)

Abstract The antioxidant activities of dihydric phenols, such as catechol, resorcinol, and hydroquinone, and their twenty-three alkyl and benzyl substituted derivatives were evaluated by means of an oxygen-absorption method at 60 °C for determining the oxidation of tetralin. Catechols exhibited a much higher stoichiometric factor (2.0—2.3) compared with those of other compounds. The stoichiometric factors of hydroquinones (0.6—1.1) are almost half those of catechols, and are lower for the resorcinols (0.3—0.6). In addition, the rates of oxidation during the induction period (Rinh) were 1.1—1.6 × 10−6, 3.0—3.8 × 10−6, and 13.3—18.4 × 10−6 M min−1 for catechols, hydroquinones, and resorcinols, respectively. According to these results, catechols and hydroquinones are efficient antioxidants, and their activities may be dependent on the stability of phenoxyl radicals as oxidation products due to the formation of the quinone structure. Furthermore, the stability of phenoxyl radicals derived from catechols is higher than that of those from hydroquinones. In spite of having two OH substituents, resorcinols behave as monohydric phenols in the reaction with peroxyl radicals.
The nucleus basalis (Ch4) in the alcoholic Wernicke-Korsakoff syndrome: reduced cell number in both amnesic and non-amnesic patients (1997)

Whereas neurons in the nucleus basalis are at risk in thiamine deficient alcoholic patients, cell loss is minor and does not account for the profound memory disorder.
Effect of Molecular Mass and Degree of Deacetylation of Chitosan on Adsorption of Streptococcus sobrinus 6715 to Saliva Treated Hydroxyapatite. (2002)

We evaluated the influence of molecular mass and degree of deacetylation of chitosan on the adsorption of Streptococcus sobrinus 6715 to saliva-treated hydroxyapatite (S-HA) by measuring the optical density of the bacterial cell suspensions released from saliva-treated hydroxyapatite. Twenty-five chitosan samples with different molecular masses (0.8-6 kDa) and degrees of deacetylation (10-95%) were prepared for the study. We found that the inhibition of adsorption of S. sobrinus 6715 to S-HA correlated positively with the molecular mass of chitosan (R = 0.876) and that the optimal degree of deacetylation was 50-60% for maximum inhibition of bacterial binding to S-HA. We also examined the effect of chitosan on zeta potentials of the oral bacteria and their surface hydrophobicities. It was observed that chitosan reduced the magnitude of the zeta potential and surface hydrophobicities of the oral bacteria. Thus, the results demonstrated that chitosan with a molecular mass of 5-6 kDa and a degree of deacetylation of 50-60% might have the potential to act as an effective anti-plaque agent because of its polycationic properties.
Optimization of waveguide coupling lenses with optical design software (1996)

We show that the coupling efficiency of an optical system to a waveguide can be related to an apodized and normalized point spread function. Adapting the problem to the use of optical design software, we analyze and optimize systems that contain a fair amount of aberration. We compare theoretical predictions with experimental results and obtain good agreement.
최대전력 추종시스템의 ASIC 설계 (2005)

본 논문에서는 태양광발전시스템을 구성하여 태양전지로부터 안정된 최대 출력을 얻기 위해 퍼지제어기를 사용한 최대출력점 추종방법을 제시하였다. 제시된 퍼지제어기는 승압형 Boost Converter의 제어에 적용되었다. 그리고 퍼지제어기를 하드웨어 직접 설계가 가능한 FPGA로 구현하여 재설계의 용이성과 비용 절감, 그리고 빠른 추종 시간을 갖도록 하였다.
Current Reusing VCO and Divide-by-Two Frequency Divider for Quadrature LO Generation (2008)

For low-power and accurate quadrature local oscillator (LO) signal generation, an <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">LC</i> -tank voltage controlled oscillator (VCO) operating at double the required LO-frequency reuses the bias current of divide-by-two frequency divider. The current reusing VCO and divide-by-two frequency divider are targeted to generate the LO signals for a 1.57 GHz global positioning system receiver. Implemented in a 0.18 mum CMOS technology, the current reusing VCO and divide-by-two frequency divider consumes 1.7mA from a 1.8 V supply. The measured phase noise is -120dBc/Hz at 1 MHz offset when the carrier frequency is 1.57GHz.
A New Lattice-Reduction-Based Receiver for MIMO Systems (2007)

In this paper, a new practical lattice reduction scheme, Seysen's algorithm, is combined with linear detectors such as Zero Forcing, MMSE and extended MMSE for MIMO digital communications. Seysen-based lattice-reduction aided detectors achieve the same diversity order as the optimum ML detector. It outperforms the existing LLL-based lattice-reduction aided detector. The performance improvement is more profound for MIMO systems with a larger number of transmit and receive antennas. Moreover, Seysen requires less computational time than the LLL scheme.
Prevalence and clinical features of pigmented oral lesions (2015)

Pigmentations of the oral mucosa are common. Gingivae and buccal mucosae are the most common sites for oral pigmentations. Proper history and recognition of clinical features are important for effective management.
Preferences of patients and health professionals for route and frequency of administration of biologic agents in the treatment of rheumatoid arthritis (2014)

The majority of RA patients treated with biologics preferred their current route of administration. Most patients, those inexperienced with biologics, and HPs favored SCH. Low treatment frequencies were generally preferred.
Fe<sub>2</sub>P@mesoporous carbon nanosheets synthesized <i>via</i> an organic template method as a cathode electrocatalyst for Zn–air batteries (2019)

Organic layers were formed using a melamine crystal template, which transformed carbon nanosheets with Fe<sub>2</sub>P into a mesoporous structure after carbonization.
PALM imaging and cluster analysis of protein heterogeneity at the cell surface (2010)

The authors employed photoactivatable localization microscopy (PALM) and direct stochastic optical reconstruction microscopy (dSTORM) imaging and image analysis based on Ripley's K-function to quantify the distribution and heterogeneity of proteins at the cell plasma membrane. The membrane targeting sequence of the N-terminal region of the T cell receptor-pathway kinase Lck fused to the photo-convertible fluorescent protein tdEos (Lck(N10)-tdEos), clusters into sub-100 nm regions which cover approximately 7% of the cell surface. 2-channel PALM imaging of Lck(N10)-tdEos and the N-terminus of the kinase Src (Src(N15)-PS-CFP2) are demonstrated. Finally, T cell microclusters at the immune synapse are imaged at super-resolution using dSTORM, showing that conventional TIRF images contain unresolved, small clusters. These methods are generally applicable to other cell and fluorophore systems to quantify 2-D molecular clustering at nanometer scales.
Bovine Lactoferrin Inhibits Adenovirus Infection by Interacting with Viral Structural Polypeptides (2003)

We recently demonstrated that lactoferrin, an antimicrobial glycoprotein, can inhibit adenovirus infection by competing for common glycosaminoglycan receptors. This study further characterizes the antiadenovirus activity of the protein, thus demonstrating that lactoferrin neutralizes infection by binding to adenovirus particles and that its targets are viral III and IIIa structural polypeptides.
LNA real-time PCR probe quantification of hepatitis B virus DNA (2011)

In the present study, we standardized a TaqMan locked nucleic acid (LNA) real-time polymerase chain reaction (PCR) probe for the accurate quantification and detection of hepatitis B virus (HBV) DNA in serum (plasma), and evaluated its methodology. LNA probe technology had a much better detection performance in HBV DNA than the common TaqMan probe. The assay based on the LNA probe had a wider linear detection range, higher sensitivity, stability and amplification efficiency, and a lower concentration of probes than the TaqMan probe. Among the 15 cases with chronic hepatitis B surface antigen (HBsAg) (+) alone, only 4 cases that were detected by TaqMan real-time PCR were negative; however, the same samples were positive by LNA real-time PCR (p<0.05). A positive correlation between viral load measurements for the 35 samples with HBV-positive DNA was detected in both LNA and TaqMan real-time PCR.
A hierarchical scheduling system using new weight assigned function in VLSI development lines (2002)

Many kinds of scheduling systems have been devised in order to realize an efficient operation of production lines by means of, for example, shortening turn around time (TAT). The VLSI development line requires the following special key items: (1) an efficient lot processing schedule as the number of process steps in given period are maximized; (2) the quick making of a schedule counteracting the alternation of recipes and changes of the period demanded for the experimentation. We developed a new hierarchical scheduling system (DYSCHE II: DYnamic SCHEduling system II) using a Weight Assigned Function (WAF) to overcome the problem of conventional scheduling systems.
Effect of Dexamethasone on Days Alive and Ventilator-Free in Patients With Moderate or Severe Acute Respiratory Distress Syndrome and COVID-19 (2020)

ClinicalTrials.gov Identifier: NCT04327401.
BET inhibitors in the treatment of hematologic malignancies: current insights and future prospects (2016)

The bromodomain and extra-terminal (BET) family of proteins are important epigenetic regulators involved in promoting gene expression of critical oncogenes. BET inhibitors have been demonstrated to repress c-Myc expression, and were initially shown to have efficacy in a number of c-Myc-dependent hematologic malignancies. Recent studies have now revealed a broader role for BET inhibitors in hematologic malignancies. In this review, we summarize the efficacy of BET inhibitors in preclinical models of acute leukemia, lymphoma, and multiple myeloma. We also summarize recent results of clinical trials utilizing BET inhibitors in hematologic malignancies, characterize potential resistance mechanisms to BET inhibitors, and discuss potential combination therapies with BET inhibitors in patients with hematologic malignancies.
Logic operations using a bistable etalon with two control beams (1985)

The theory and demonstration of a novel scheme for performing two-input binary logic operations with a bistable etalon are reported. The scheme employs two edge-injected CO laser beams to control the reflectivity of an InSb etalon. The control beams serve as the inputs to the logic device, while the output is provided by the reflected beam. The application of such a device to two-dimensional array processing is discussed.
Multipath Elimination for the Low-Cost Consumer GPS (1996)

Early GPS receivers used three correlation points in each
chmel to control the tracking. The spacing was
conventionally 1 microsecond, maximising the gain of
the error function.

Today, professional and survey versions use
sophisticated means of reducing multipath, such as the
narrow correlator approach (Novatel) or the multipath
estimating/eliminating methods (Novatel Delft). Some
consumer models have used multiple correlators on a
single satellite to achieve a rapid acquisition time(JRC),
rather than for multipath elimination. The third option is
that of minimal cost, for consumer applications in private
cars.

The next generation requires all three parameters . . that
is fast acquisition time, for use in cities, precision, to
allow map-matching, even in the down-town multipath
environment, and extremely low cost.

The low-cost, fast acquisition technology has been
presented elsewhere (Mattos, ION-GPS95). This paper
concentmtes on the code tracking technology to achieve
freedom from multipath distortion by algorithm only.
Antigenic Diversity Thresholds and the Development of AIDS (1991)

Longitudinal studies of patients infected with HIV-1 reveal a long and variable incubation period between infection and the development of AIDS. Data from a small number of infected patients show temporal changes in the number of genetically distinct strains of the virus throughout the incubation period, with a slow but steady rise in diversity during the progression to disease. A mathematical model of the dynamic interaction between viral diversity and the human immune system suggests the existence of an antigen diversity threshold, below which the immune system is able to regulate viral population growth but above which the virus population induces the collapse of the CD4+ lymphocyte population. The model suggests that antigenic diversity is the cause, not a consequence, of immunodeficiency disease. The model is compared with available data, and is used to assess how the timing of the application of chemotherapy or immunotherapy influences the rate of progress to disease.
Frequency domain equalization for the multicarrier spread spectrum system in multipath fading channel (2002)

The combination of orthogonal frequency division multiplexing (OFDM) with direct sequence spread spectrum (DS/SS) is suitable for the design of a multiuser system robust against channel impairments. We propose a frequency domain equalization method for the OFDM-DS/SS system in mobile fading channels. It is shown that the learning constant is a key factor which is chosen depending on the channel conditions. By using the adaptive teaching constant, the average performance of the equalizer can be improved.
Purification and characterization of human coagulation factor V. (1981)

We have purified human coagulation Factor V 6,000-fold to homogeneity from citrated plasma using polyethylene glycol 6000 precipitation, adsorption of Factor V to barium citrate, DEAE-Sepharose chromatography, and gel filtration on Ultrogel AcA 34 (yield 21%). Human Factor V is a single polypeptide chain before and after disulfide bond reduction with an apparent Mr = 335,000 as determined by electrophoresis on 5% acrylamide sodium dodecyl sulfate gels. Human Factor V is a glycoprotein containing 13% of weight carbohydrate and there is a high content of sialic acid (86 residues/mol) compared to the other sugars. When human Factor V is treated with thrombin, coagulation activity increases 25- to 30-fold to a specific activity of 1.7 to 2.0 units/microgram. Thrombin activation is accompanied by the cleavage of three bonds in the Factor V molecule. We have detected activation intermediates with apparent Mr = 295,000 and 248,000 and final products with apparent Mr = 150,000, 121,000, and a doublet at 95,000-91,000 as judged by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The final products of thrombin activation of human Factor V and bovine Factor V are similar, yet the intermediates observed are different. This suggests that cleavages are made at similar locations in bovine and human Factor V, but that they occur in a different sequence. When human Factor V is treated with the Factor V activator from Russell's viper venom, it is split into two components with apparent Mr = 303,000 and 95,000-91,000 and is fully activated. The increase in coagulation activity observed upon treatment of human Factor V with thrombin or the Factor V activator from Russell's viper venom seems to correlate with the generation of the doublet Mr = 95,0090-91,000 component.
Handwritten Signature Verification: New Advancements and Open Issues (2012)

Recently, research in handwritten signature verification has been considered with renewed interest. In fact, in the age of e-society, handwritten signature still represents an extraordinary means for personal verification and the possibility of using automatic signature verification in a range of applications is becoming a reality. This paper focuses on some of the most remarkable aspects the field and highlights some recent research directions. A list of selected publications is also provided for interested researchers.
Communicating abstract data type values in heterogeneous distributed programs (2002)

This paper is concerned with the problem of communicating abstract data type (ADT) values in heterogeneous distributed programs. It focuses on addressing two fundamental issues of the problem: the selection of suitable exchange representations and the generation of data converters. Exchange representations are the ways to represent data during transmissions across networks. Data converters are programs transforming data from one representation to another; they are the major facility to deal with heterogeneity in a communication. This paper reports the following results: a term-based exchange representation, which is an abstract notation and so is particularly suitable for communicating ADT values in heterogeneous programs; and methods to generate data converters.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>