gebhart/patrepeval huggingface dataset:
Gas-Liquid Cylindrical Cyclone (GLCC©) Compact Separators For Wet Gas Applications (2003)

Gas-Liquid Cylindrical Cyclone (GLCC©1) separators are becoming increasingly popular as attractive alternatives to conventional separators as they are simple, compact, less expensive, have low-weight, and require little maintenance. However, present studies focus on GLCC designs and applications at relatively lower gas velocities (below the minimum velocity for onset of liquid carry-over in the form of annular/mist flow). With appropriate modifications, GLCCs can be used for wet gas (high gas liquid ratio, GLR) applications, characterized by higher gas velocities, to knock out the liquid droplets from the gas core. The objectives of this study are to design a novel GLCC capable of separating liquid from a wet gas stream; conduct experimental investigations to evaluate the GLCC performance improvement in terms of operational envelope for liquid carry-over; and, quantify the liquid extraction from the gas stream. GLCC design considerations/guidelines for wet gas application are also provided based on the experimental studies at low pressures. This investigation extends the capabilities of compact separators for wet gas applications for insitu gas volume fraction (GVF) greater than 95%.
Assessing and improving the knowledge of orthopaedic foundation‐year doctors (2010)

we show that set against the basic expectations of orthopaedic consultants, generic foundation-doctor education is inadequate. However, after a focussed teaching programme instigated at the beginning of the job, standards improved significantly. Our results also show that junior doctors' confidence and enjoyment of the speciality also increased.
Structural, Biochemical, and Functional Characterization of the Calcium Sensor Neurocalcin δ in the Inner Retinal Neurons and Its Linkage with the Rod Outer Segment Membrane Guanylate Cyclase Transduction System (2004)

This study documents the detailed biochemical, structural, and functional identity of a novel Ca(2+)-modulated membrane guanylate cyclase transduction system in the inner retinal neurons. The guanylate cyclase is the previously characterized ROS-GC1 from the photoreceptor outer segments (PROS), and its new modulator is neurocalcin delta. At the membrane, the myristoylated form of neurocalcin delta senses submicromolar increments in free Ca(2+), binds to its specific ROS-GC1 domain, and stimulates the cyclase. Neurocalcin delta is not present in PROS, indicating the absence of the pathway in the outer segments and the dissociation of its linkage with phototransduction. Thus, the pathway is linked specifically with the visual transduction machinery in the secondary neurons of the retina. With the inclusion of this pathway, the findings broaden the understanding of the existing mechanisms showing how ROS-GC1 is able to receive and transduce diverse Ca(2+) signals into the cell-specific generation of second-messenger cyclic GMP in the retinal neurons.
Amyloid Precursor Protein Is Trafficked and Secreted via Synaptic Vesicles (2011)

A large body of evidence has implicated amyloid precursor protein (APP) and its proteolytic derivatives as key players in the physiological context of neuronal synaptogenesis and synapse maintenance, as well as in the pathology of Alzheimer's Disease (AD). Although APP processing and release are known to occur in response to neuronal stimulation, the exact mechanism by which APP reaches the neuronal surface is unclear. We now demonstrate that a small but relevant number of synaptic vesicles contain APP, which can be released during neuronal activity, and most likely represent the major exocytic pathway of APP. This novel finding leads us to propose a revised model of presynaptic APP trafficking that reconciles existing knowledge on APP with our present understanding of vesicular release and recycling.
RPTPα is essential for NCAM-mediated p59fyn activation and neurite elongation (2004)

The neural cell adhesion molecule (NCAM) forms a complex with p59fyn kinase and activates it via a mechanism that has remained unknown. We show that the NCAM140 isoform directly interacts with the intracellular domain of the receptor-like protein tyrosine phosphatase RPTPalpha, a known activator of p59fyn. Whereas this direct interaction is Ca2+ independent, formation of the complex is enhanced by Ca2+-dependent spectrin cytoskeleton-mediated cross-linking of NCAM and RPTPalpha in response to NCAM activation and is accompanied by redistribution of the complex to lipid rafts. Association between NCAM and p59fyn is lost in RPTPalpha-deficient brains and is disrupted by dominant-negative RPTPalpha mutants, demonstrating that RPTPalpha is a link between NCAM and p59fyn. NCAM-mediated p59fyn activation is abolished in RPTPalpha-deficient neurons, and disruption of the NCAM-p59fyn complex in RPTPalpha-deficient neurons or with dominant-negative RPTPalpha mutants blocks NCAM-dependent neurite outgrowth, implicating RPTPalpha as a major phosphatase involved in NCAM-mediated signaling.
Study on the optimization design of flow channels and heat dissipation performance of liquid cooling modules (2009)

As the system functions of electronic equipments increase, and the power of micro-electronics elements becomes more and more higher, heat dissipation is more and more taken seriously. The importance of thermal design in electronic equipment is introduced in this paper. Further more, using Flotherm simulatively analyze modules with different flow channel configurations and parameters, so as to obtain such parameters as temperature, flow rate and pressure-loss of different fluid flow. At the same time, by making a comparative analysis on these results, relevant conclusions have been drawn.
Identification of C‐glycoside analogues that display a potent biological activity against murine and human invariant natural killer T cells (2009)

We have recently shown that alpha-C-galactosylceramide (alpha-C-GalCer) stimulates invariant natural killer T (iNKT) cells and preferentially induces a T helper 1 (Th1)-type response in mice. However, alpha-C-GalCer was found to be a rather weak ligand against human iNKT cells in vitro. Therefore, in this study, we sought to identify a compound that displays a strong stimulatory activity against human iNKT cells, by determining the biological activities of several C-glycoside analogues. From the in vitro screening assays, we found that almost all C-glycoside analogues, which have an E-alkene linker between sugar and lipid moieties, are able to activate human iNKT cells and to induce the maturation and activation of human dendritic cells through iNKT-cell activation. In summary, although alpha-galactosylceramide (alpha-GalCer) remains the strongest iNKT-cell ligand, our study identified E-alkene-linked C-glycoside analogues as potent human iNKT-cell stimulants, and indicated that these analogues could be used as a therapeutic agent in the future for diseases resolved by Th1-type responses.
Principles of banking (1998)

Introducing students who are new to banking its evolution, basic principles, and current issues, this text presents an overview of banking fundamentals, along with various issues and developments important in understanding the contemporary scene. This edition addresses particularly the influences of new technology and regulation in the areas of customer service, emerging technology and marketing. Additionally, the concept of a proactive bank employee with a customer service focus is a consistent theme througout the text.
Adaptive identification and control for manipulators without using joint accelerations (2005)

We present a new scheme for the adaptive control of mechanical manipulators along with proof of convergence. This work is an extension of our earlier work [Craig, Hsu and Sastry] [1]. The new scheme does not require the measurement of joint accelerations and needs less computation. We illustrate the theory with some simulations.
Lehbet (Georges), Piaget (Jean) et coll. — Psychothèque (1973)

Ginet Dominique. Lehbet (Georges), Piaget (Jean) et coll. — Psychothèque. In: Revue française de pédagogie, volume 25, 1973. pp. 65-67.
On a General Theory of Anomalies and Energy Absorption by Diffraction Gratings and Their Relation with Surface Waves (1978)

The authors generalize a previous theory to study the phenomenon of absorption of plane waves by a grating working with several spectral orders. The theory allows predicting, with the aim of a simple formula, the shape of various kinds of grating anomalies, as well as the shape of the total diffracted energy curve. The use of a convenient matrix, called S*S, leads to the introduction of the efficiency hyperellipsoid. This enables one to predict in a simple way a phenomenon of total absorption of a finite number of plane waves by a grating.
Near-wall streaky structure in a turbulent boundary layer on a cylinder (1991)

A near-wall streaky structure has been identified in a turbulent boundary layer on a cylinder in axial flow. A platinum wire looped around a cylinder moving in a tank of quiescent water was used to generate hydrogen bubbles near the wall of the cylinder. The streaks that were visualized correspond to high-speed streaks identified by Kline et al. [J. Fluid Mech. 30, 741 (1967)]. The appearance, motion, and spacing of the streaks appear similar to the streaky structure in a planar boundary layer, suggesting a similarity in the mechanism for the generation of turbulence in the boundary layers on a flat plate and on a cylinder.
Scissors: dealing with header redundancies in data centers through SDN (2012)

Growing concern for reduced power dissipation, cost and latency demands in next generation Data Centers (DC) motivates us to revisit header optimizations. Headers contribute to about 30–40% of DC traffic and is responsible for equal proportion of consumed power. This amounts to significant overhead on per byte transfer of payload. In the past, highly inflexible switches have limited the focus of header optimizations primarily on end-host or edge network routers. Further, strict compliance to protocols by switches/routers along the path have limited the segments of headers that can be optimized. Recent evolution of Software Defined Network (SDN) brings in several opportunities to control over switches. We believe that if SDN's finer handle to the switching devices is exploited, it can help deal with header information. In this paper, we exploit the capabilities of SDN and introduce a new functionality that can effectively replace the redundant and repetitive header information with shorter unique identity. We present Scissor that trims the headers lower in the protocol stack. As a replacement for routing, we introduce the notion of Flow-ID, where all packets belonging to a flow are identified using this unique Flow-ID. We leverage the capabilities of the SDN to dynamically allow switching devices to route the packets based on the Flow-IDs. Our approach of trimming header at the switching devices leaves the hosts unmodified making it highly adoptable for DC environment. We show that our approach can decrease switch fabric power consumption by a factor of 2.5 compared to an existing L2 switch and reduce the latency by about 30% for a significant fraction (around 30–50%) of the network traffic.
Localized tactile stimulation by time-reversal of flexural waves: Case study with a thin sheet of glass (2013)

This paper addresses the issue of producing localized tactile stimuli on a transparent surface. An approach based on time reversal of acoustic waves is presented and implemented on a thin glass surface actuated by piezoelectric transducers located at the periphery. The physical performance measurement, completed by a user study demonstrates the ability to provide localised and perceivable tactile stimulation.
Optically pre-amplified photodetectors for multi-guide vertical integration in InP (2009)

An integrated optically pre-amplified photodetector, featuring waveguide gain and absorption sections defined on the same active waveguide layers atop a common passive waveguide, is reported. The device demonstrates high responsivity while exhibiting little polarization sensitivity.
Effect of ciliary neurotrophic factor (CNTF) on motoneuron survival (1991)

We have demonstrated that the extensive degeneration of motoneurons in the rat facial nucleus after transection of the facial nerve in newborn rats can be prevented by local ciliary neurotrophic factor (CNTF) administration. CNTF differs distinctly from known neurotrophic molecules such as NGF, BDNF and NT-3 in both its molecular characteristics (CNTF is a cytosolic rather than a secretory molecule) and its broad spectrum of biological activities. CNTF is expressed selectively by Schwann cells and astrocytes of the peripheral and central nervous system, respectively, but not by target tissues of the great variety of CNTF-responsive neurons. CNTF mRNA is not detectable by Northern blot or PCR analysis during embryonic development and immediately after birth. However, during the second post-natal week, a more than 30-fold increase in CNTF mRNA and protein occurs in the sciatic nerve. Since the period of low CNTF levels in peripheral nerves coincides with that of high vulnerability of motoneurons (i.e. axonal lesion results in degeneration of motoneuron cell bodies), insufficient availability of CNTF may be the reason for the rate of lesion-induced cell death of early post-natal motoneurons. Highly enriched embryonic chick motoneurons in culture are supported at survival rates higher than 60% by CNTF, even in single cell cultures, indicating that CNTF acts directly on motoneurons. In contrast to CNTF, the members of the neurotrophin gene family (NGF, BDNF and NT-3) do not support the survival of motoneurons in culture. However, aFGF and bFGF show distinct survival activities which are additive to those of CNTF, resulting in the survival of virtually all motoneurons cultured in the presence of CNTF and bFGF.
Detailed transcriptome atlas of the pancreatic beta cell (2009)

Our gene atlas is a valuable source for detailed information on the gene expression distribution in beta cells and pancreatic islets along with insulin producing cell lines. The BCGA tool, as well as the data and code used to generate the Atlas are available at the T1Dbase website (T1DBase.org).
Polycyanation. The Reaction of Cyanogen Chloride, Cyclopentadiene, and Sodium Hydride (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPolycyanation. The Reaction of Cyanogen Chloride, Cyclopentadiene, and Sodium HydrideO. W. WebsterCite this: J. Am. Chem. Soc. 1966, 88, 13, 3046–3050Publication Date (Print):July 1, 1966Publication History Published online1 May 2002Published inissue 1 July 1966https://doi.org/10.1021/ja00965a028Request reuse permissionsArticle Views550Altmetric-Citations88LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (571 KB) Get e-Alertsclose Get e-Alerts
Role of the mu immunoglobulin heavy chain transmembrane and cytoplasmic domains in B cell antigen receptor expression and signal transduction. (1993)

Membrane immunoglobulins (mIg) serve as the recognition components of B lymphocyte antigen receptors. Binding of antigen to these receptors leads to dramatic effects on B cell growth and viability. We have examined the structural elements of mIgM that are involved in antigen receptor assembly and function. Expression of transfected wild-type mIgM in a B cell line led to assembly with the other two known components of the antigen receptor, Ig-alpha and Ig-beta, expression on the cell surface, and when cross-linked by anti-IgM antibodies, stimulation of signal transductin reactions, including tyrosine protein phosphorylation, inositol phosphate production, and increases in cytoplasmic calcium concentration. Replacement of the highly conserved COOH-terminal 41 amino acids of mIgM heavy chain (mu m) with the transmembrane and cytoplasmic domains of human CD8 alpha resulted in a molecule which was expressed on the B cell surface at levels comparable to wild-type mIgM, but which did not form a complex with Ig-alpha or Ig-beta and did not stimulate any of the signaling reactions mentioned above. Replacement of the basic three-amino-acid cytoplasmic domain of mu m with a different but similarly charged sequence had no effect on cell-surface expression or signaling function. On the other hand, removal of the entire cytoplasmic domain resulted in a molecule which did not bind Ig-alpha and Ig-beta and which did not transduce signals. This effect is probably due to altered post-translational processing of this mutant molecule. Finally, a series of eight single-amino-acid substitutions in the transmembrane domain was constructed. Most of these resulted in the removal of hydroxyl groups from conserved residues postulated to be important for interactions with other components. Each of these mutant molecules was capable of transducing signals when cross-linked by anti-IgM, but one was partially defective. Since alteration of any single residue was not sufficient to disrupt signaling completely, the interactions required for signaling are likely to involve multiple residues, so that elimination of one hydroxyl group does not prevent the interaction. We propose that the cytoplasmic domain of mu m does not play a critical role in receptor function but that the transmembrane domain specifies interactions with other components, probably Ig-alpha and Ig-beta, required for proper antigen receptor signal transduction.
Measurement of Single Soybean Seed Attributes by Near-Infrared Technologies. A Comparative Study (2012)

Four near-infrared spectrophotometers, and their associated spectral collection methods, were tested and compared for measuring three soybean single-seed attributes: weight (g), protein (%), and oil (%). Using partial least-squares (PLS) and four preprocessing methods, the attribute that was significantly most easily predicted was seed weight (RPD > 3 on average) and protein the least. The performance of all instruments differed from each other. Performances for oil and protein predictions were correlated with the instrument sampling system, with the best predictions using spectra taken from more than one seed angle. This was facilitated by the seed spinning or tumbling during spectral collection as opposed to static sampling methods. From the preprocessing methods utilized, no single one gave the best overall performances but weight measurements were often more successful with raw spectra, whereas protein and oil predictions were often enhanced by SNV and SNV + detrending.
A Method of Bivariate Trimming for Robust Estimation of the Correlation Coefficient (1978)

A. C. Bebbington, A Method of Bivariate Trimming for Robust Estimation of the Correlation Coefficient, Journal of the Royal Statistical Society. Series C (Applied Statistics), Vol. 27, No. 3 (1978), pp. 221-226
Patiromer in Patients with Kidney Disease and Hyperkalemia Receiving RAAS Inhibitors (2014)

In patients with chronic kidney disease who were receiving RAAS inhibitors and who had hyperkalemia, patiromer treatment was associated with a decrease in serum potassium levels and, as compared with placebo, a reduction in the recurrence of hyperkalemia. (Funded by Relypsa; OPAL-HK ClinicalTrials.gov number, NCT01810939.).
Dismissed Employees and Orders for Discovery (1998)

Dismissed Employees and Orders for Discovery DAVID LEWIS DAVID LEWIS Centre for Research in Industrial and Commercial Law, Middlesex University Search for other works by this author on: Oxford Academic Google Scholar Industrial Law Journal, Volume 27, Issue 1, March 1998, Pages 64–66, https://doi.org/10.1093/ilj/27.1.64 Published: 01 March 1998
An efficient controller scheme for MPEG-2 video decoder (1998)

A video decoder with an efficient block-level-pipeline controller scheme for MPEG-2 MP@ML is presented. The architecture in most of the reported literature for MPEG-2 MP@ML video uses a 64-bit bus and a complex bus arbitration scheme to communicate with the external DRAM, the display, and the incoming FIFO. Our design imposes a certain order in the DRAM access by various processing units instead of allowing any processing unit within the decoder to request bus access arbitrarily. This efficient DRAM accessing order allows us to reduce bus width from 64 bits to 32 bits, without significantly increasing the embedded buffer sizes, and still meet the requirements for MPEG-2 MP@ML real-time decoding. The bus arbitration algorithm is also simple, allowing for a less complex controller design.
<title>Frequency Division Multiplexing Optical Processors</title> (1982)

This paper describes a method by which optical time- and space-integrating processors may be generalized and expanded by accommodating vector inputs. Many architectures using this frequency division multiplexing approach are presented, demonstrating new operations and generalizations of old ones.
Deadlock-free fine-grained thread migration (2011)

Several recent studies have proposed fine-grained, hardware-level thread migration in multicores as a solution to power, reliability, and memory coherence problems.The need for fast thread migration has been well documented, however, a fast, deadlock-free migration protocol is sorely lacking: existing solutions either deadlock or are too slow and cumbersome to ensure performance with frequent, fine-grained thread migrations.In this study, we introduce the Exclusive Native Context (ENC) protocol, a general, provably deadlock-free migration protocol for instruction-level thread migration architectures.Simple to implement, ENC does not require additional hardware beyond common migration-based architectures.Our evaluation using synthetic migrations and the SPLASH-2 application suite shows that ENC offers performance within 11.7% of an idealized deadlock-free migration protocol with infinite resources.
Current perspectives on<i>Mycobacterium avium</i>subsp.<i>paratuberculosis,</i>Johne’s disease, and Crohn’s disease: a Review (2011)

Mycobacterium avium subsp. paratuberculosis (MAP) causes the disease of cattle, Johne's. The economic impact of this disease includes early culling of infected cattle, reduced milk yield, and weight loss of cattle sold for slaughter. There is a possible link between MAP and Crohn's disease, a human inflammatory bowel disease. MAP is also a potential human food borne pathogen because it survives current pasteurization treatments. We review the current knowledge of MAP, Johne's disease and Crohn's disease and note directions for future work with this organism including rapid and economical detection, effective management plans and preventative measures.