gebhart/patrepeval huggingface dataset:
Extraction of Simple Sentences from Mixed Sentences for Building Korean Case Frames (1999)

A large number of simple sentences are needed to construct practical Case frames automatically. Until now, most studies have assumed that there are already extensive training data (especially here simple sentences) and linguistic information for their work. However, this is not true at least of Korean. Furthermore, Korean syntactic structures are significantly different from those of English. So, this paper first of all, compares Korean with English in relation to extracting simple sentences from mixed ones. Second, we suggest fundamental and detailed principles. For convenience and practicality, however, we deliberately exclude some linguistic phenomena. Finally, we attempt to develop a reliable algorithm to extract simple sentences with the ultimate goal of building Case frames. 1. INTRODUCTION In NLP, the Case frames of a language are very important for a correct syntactic and semantic analysis of the language. The term Case frames is originated from the Case grammar of Fillmore. H...
A new role for vitamin D: cholecalciferol promotes dermal wound strength and re-epithelization. (1993)

Vitamin D endocrine system is a potent regulator of cell growth and maturation. Vitamin D3 modulates growth kinetics of many cells and produces divergent actions. Keeping this in view, cholecalciferol is evaluated for its actions on dermal wound healing in Wistar rats. Intraperitonial cholecalciferol at 5, 10, 15 IU/g body weight doses produces increases in wound breaking strength and promotes epithelization significantly. Results suggest that there is some biological role for vitamin D endocrine system, ir wound repair. A clear understanding of this role of vitamin D3 may define new avenues in wound medication.
The Spectator as Theorist: A Reply (1989)

Preview this article: The Spectator as Theorist: A Reply, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/ee/21/1/englisheducation14309-1.gif
Surgical Treatment of Patients With Advanced Glaucomatous Field Defects (1969)

Should patients with greatly restricted visual field defects from glaucoma be operated upon? Chandler and Grant in their recently published<i>Lectures on Glaucoma</i>raise the same question and ask that further data be published covering this problem. The purpose of this paper is to show our experience in facing this dilemma over the past 19 years. Fifty-two eyes with advanced glaucomatous field defects which have had filtration operations were evaluated. They were classifield into three categories according to the severity of the visual field loss. None was included whose field exceeded 20° in any meridian. They were also studied by age group, preoperative and postoperative pressures, central vision, and length of time followed after operation.
Oxidative destruction of erythrocyte ghost membranes catalyzed by the doxorubicin-iron complex (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOxidative destruction of erythrocyte ghost membranes catalyzed by the doxorubicin-iron complexCharles E. Myers, Luca Gianni, Charles B. Simone, Raymond Klecker, and Raymond GreeneCite this: Biochemistry 1982, 21, 8, 1707–1713Publication Date (Print):April 13, 1982Publication History Published online1 May 2002Published inissue 13 April 1982https://pubs.acs.org/doi/10.1021/bi00537a001https://doi.org/10.1021/bi00537a001research-articleACS PublicationsRequest reuse permissionsArticle Views358Altmetric-Citations189LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Identification and characterization of a major early cytomegalovirus DNA-binding protein (1986)

We characterized a DNA-binding protein with an approximate molecular weight of 129,000 (DB129) which is present in the nuclei of cytomegalovirus- (strain Colburn) infected cells, but not in virus particles. Results of two types of experiments demonstrated that DB129 is a member of the early class of herpesviral proteins. First, time course pulse-labeling experiments showed that its synthesis begins after that of the immediate-early protein IE94, but prior to the appearance of late viral proteins, and was reduced at late times. Second, in the presence of inhibitors of viral DNA replication, DB129 continued to be made and accumulated to elevated levels. A second set of experiments showed that DB129 bound to single-stranded DNA in vitro and was eluted by a NaCl gradient in two peaks, one at about 0.2 M and the second at about 0.6 M. A similar pattern of release was observed when infected-cell nuclei were serially extracted with increasing NaCl concentrations. In addition, treatment of nuclei with DNase I selectively released DB129, along with a small but significant fraction of another DNA-binding protein, DB51. These results suggest that DB129 is associated with DNA in vivo and that it interacts directly with single-stranded DNA. It was also shown that cells infected with human cytomegalovirus (strain Towne) contain a slightly larger counterpart to DB129, which was designated DB140. Similarities between these proteins and the major DNA-binding protein of herpes simplex virus are discussed.
Nanotopographical Control of Human Osteoprogenitor Differentiation (2007)

Current load-bearing orthopaedic implants are produced in 'bio-inert' materials such as titanium alloys. When inserted into the reamed bone during hip or knee replacement surgery the implants interact with mesenchymal populations including the bone marrow. Bio-inert materials are shielded from the body by differentiation of the cells along the fibroblastic lineage producing scar tissue and inferior healing. This is exacerbated by implant micromotion, which can lead to capsule formation. Thus, next-generation implant materials will have to elicit influence over osteoprogenitor differentiation and mesenchymal populations in order to recruit osteoblastic cells and produce direct bone apposition onto the implant. A powerful method of delivering cues to cells is via topography. Micro-scale topography has been shown to affect cell adhesion, migration, cytoskeleton, proliferation and differentiation of a large range of cell types (thus far all cell types tested have been shown to be responsive to topographical cues). More recent research with nanotopography has also shown a broad range of cell response, with fibroblastic cells sensing down to 10 nm in height. Initial studies with human mesenchymal populations and osteoprogenitor populations have again shown strong cell responses to nanofeatures with increased levels of osteocalcin and osteopontin production from the cells on certain topographies. This is indicative of increased osteoblastic activity on the nanotextured materials. Looking at preliminary data, it is tempting to speculate that progenitor cells are, in fact, more responsive to topography than more mature cell types and that they are actively seeking cues from their environment. This review will investigate the range of nanotopographies available to researchers and our present understanding of mechanisms of progenitor cell response. Finally, it will make some speculations of the future of nanomaterials and progenitor cells in tissue engineering.
Protecting spermatogenesis from damage induced by doxorubicin using the luteinizing hormone-releasing hormone agonist leuprorelin (1997)

The significant prophylactic effect (P < 0.05) of the LHRH agonist against doxorubicin-induced spermatogenetic damage was demonstrated by Johnsen's score and image analysis (%1C, %2C, and %4C).
SYNTHESIS OF LONG CHAIN N-ALKYLLACTYLAHINES FROM UNPROTECTED LACTOSE A NEV SERIES OF NON-IONIC SURFACTANTS (1991)

Abstract Surfactants based on sugars are employed in the extraction of proteins and in chiral synthesis. However, all current methods for their preparation require initial protection of the sugar giving rise to a long and costly synthesis. We describe here a two stage route to a new series of non-ionic surfactants starting from unprotected lactose. The N-alkyllactylamines were found to have comparable surfactant properties to existing sugar-based homologs.
Standardized rates of recurrent outcomes (1994)

Longitudinal studies are often concerned with estimating the rate of an event that may recur. Examples are nonmelanoma skin cancer rates, screening rates for breast cancer using mammography and hospital admission rates. We propose simple estimators for directly and indirectly standardized summary rates and relative rates of recurrent events and their variances. We also develop an estimator of the excess rate in an area if the rate in another area applied. For non-recurrent events, the estimators are identical to the usual standardized summary rates. The estimators are independent of the underlying distribution of the event of interest and allow for unequal follow-up times and event rate heterogeneity among individuals. The method is not computationally intensive and does not require specialized software. We illustrate the application of the method in a retrospective cohort study of hospital utilization patterns of Medicare enrollees in Boston and New Haven over a three and a half year period.
Lasmiditan for the treatment of migraine (2017)

Migraine is one of the most common diseases in the world, with high economical and subjective burden. Migraine acute therapy is nowadays based on specific and non-specific drugs but up to 40% of episodic migraineurs still have unmet treatment needs and over 35% do not benefit from triptans administration. Serotonin-1F receptors have been identified in trigeminal system and became an ideal target for anti-migraine drug development as potential trigeminal neural inhibitors. Lasmiditan, a novel serotonin1F receptor agonist, showed specific affinity in vitro for the receptor without any vasoconstrictive action and inhibited markers associated with electrical stimulation of trigeminal ganglion in migraine animal models. Areas covered: This article reviews both preclinical and clinical studies on lasmiditan as a potential acute therapy for migraine, as well as pharmacokinetic and pharmacodynamic features. It also summarizes safety and tolerability data gathered in the various human studies. Expert opinion: The absence of vasoconstrictive effects makes lasmiditan a promising novel migraine acute therapy. Although preclinical and Phase I and II studies established a significant efficacy, the limited knowledge about pharmacokinetics and metabolism, the high rate of non-serious central nervous system side effects and the lack of larger studies remain still a matter of concern that should be addressed in future studies.
Analysis of an anisotropic dielectric radome (1975)

A grooved-dielectric flat radome panel is analyzed in terms of an arbitrary direction of incidence on <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">N</tex> planar slabs each of which is dielectrically anisotropic, homogeneous, and lossless. Using this model for the grooved panel, transmission coefficients of 90 percent or greater over a 10:1 frequency band and over <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0\deg</tex> to <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">60\deg</tex> incidence angle are predicted and demonstrated experimentally. Measurements are presented on two panels from 3 to 35 GHz.
Extrachromosomal Eukaryotic DNA Substrates for Switch Recombination: Analysis of Isotype and Cell Specificity (1994)

Switch recombination in B lymphocytes is a complex process directed by signals provided by cytokines and/or TH cells. To analyze these signals in an in vitro system, we have developed extrachromosomal eukaryotic substrates for switch recombination that replicate autonomously in murine cells and present pairs of switch (S) regions in an accessible mode. Switch recombination within the S regions results in the expression of the selectable neo gene. The results presented here indicate that substrates containing either S mu and S gamma 2b, S mu and S gamma 2a, or S mu and S alpha undergo switch recombination with similar frequencies in the pre-B-cell line 18-81, which has been previously reported to specifically switch to IgG2b. This indicates that, rather than expressing a gamma 2b isotype-specific recombinase, the 18-81 cells express a switch recombinase capable of acting on any accessible S region, supporting the accessibility model. The extrachromosomal substrates were rearranged in the 18-81 cells, but not in murine myeloma, T-cell, or fibroblast cell lines, supporting the idea that switch recombination is indeed regulated in a cell- and developmentally specific manner. Restriction enzyme analysis of the plasmid DNA recovered from the selected cell lines suggested multiple recombinational events, with most patterns in agreement with deletions within one or both switch regions.
<i>Msh2</i> status modulates both apoptosis and mutation frequency in the murine small intestine (1999)

Deficiency in genes involved in DNA mismatch repair increases susceptibility to cancer, particularly of the colorectal epithelium. Using Msh2 null mice, we demonstrate that this genetic defect renders normal intestinal epithelial cells susceptible to mutation in vivo at the Dlb-1 locus. Compared with wild-type mice, Msh2-deficient animals had higher basal levels of mutation and were more sensitive to the mutagenic effects of temozolomide. Experiments using Msh2-deficient cells in vitro suggest that an element of this effect is attributable to increased clonogenicity. Indeed, we show that Msh2 plays a role in the in vivo initiation of apoptosis after treatment with temozolomide, N-methyl-N'-nitro-N-nitrosoguanidine, and cisplatin. This was not influenced by the in vivo depletion of O6-alkylguanine-DNA-alkyltransferase after administration of O6-benzylguanine. By analyzing mice mutant for both Msh2 and p53, we found that the Msh2-dependent apoptotic response was primarily mediated through a p53-dependent pathway. Msh2 also was required to signal delayed p53-independent death. Taken together, these studies characterize an in vivo Msh2-dependent apoptotic response to methylating agents and raise the possibility that Msh2 deficiency may predispose to malignancy not only through failed repair of mismatch DNA lesions but also through the failure to engage apoptosis.
Glucose oxidase as the antifungal principle of talaron from <i>Talaromyces flavus</i> (1990)

Analysis of an authentic sample of the antifungal antibiotic talaron from the biocontrol fungus Talaromyces flavus indicated that approximately 40% of the solid sample was glucose oxidase. High-performance liquid chromatography elution profiles of the antimicrobial activity of talaron coeluted with those of glucose oxidase. Fluorescence emission and excitation wavelength maxima for talaron were similar to those of glucose oxidase from Aspergillus niger. The molecular weight of talaron was 152,000 with a subunit molecular weight of 71,000. The isoelectric point of talaron was pH 4.2. Mobilities of talaron on native, sodium dodecylsulfate, and isoelectric focusing polyacrylamide gels were identical with those of glucose oxidase produced by T. flavus. Furthermore, talaron had antimicrobial activity only in the presence of glucose. Hydrogen peroxide produced by the action of glucose oxidase is toxic to Verticillium dahliae. This study indicates that the antifungal activity of authentic talaron resulted from glucose oxidase produced by T. flavus.
Stereotactic breast biopsy: experience in a community setting. (1999)

This article reviews the first year experience with stereotactically guided percutaneous breast biopsy at Baptist Health Systems Women's Center. One hundred forty eight procedures were performed on one hundred forty one patients from July 1997 through July 1998. Our biopsy program is a cooperative effort involving surgeons, radiologists, pathologists, and ancillary health care personnel. In accordance with published literature, we have found the procedure to be efficacious, safe, cost effective and well accepted by patients and physicians. The advantages and limitations of minimally invasive breast biopsy are discussed as well as our concept of the role of this technique in management of patients with an abnormal mammogram.
Micro-optical Fabrication Technologies for Optical Interconnection Applications (2000)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text M. R. Taghizadeh, "Micro-optical Fabrication Technologies for Optical Interconnection Applications," in Diffractive Optics and Micro-Optics , T. Li, ed., Vol. 41 of OSA Trends in Optics and Photonics (Optical Society of America, 2000), paper DWC1. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Oxidation of Alcohols with o-Iodoxybenzoic Acid in DMSO: A New Insight into an Old Hypervalent Iodine Reagent (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOxidation of Alcohols with o-Iodoxybenzoic Acid in DMSO: A New Insight into an Old Hypervalent Iodine ReagentMarco Frigerio, Marco Santagostino, Simona Sputore, and Giovanni PalmisanoCite this: J. Org. Chem. 1995, 60, 22, 7272–7276Publication Date (Print):November 1, 1995Publication History Published online1 May 2002Published inissue 1 November 1995https://pubs.acs.org/doi/10.1021/jo00127a036https://doi.org/10.1021/jo00127a036research-articleACS PublicationsRequest reuse permissionsArticle Views8387Altmetric-Citations316LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Synthesis of azetidine-3-carboxylic acid (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of azetidine-3-carboxylic acidArthur G. Anderson Jr. and Roger LokCite this: J. Org. Chem. 1972, 37, 24, 3953–3955Publication Date (Print):December 1, 1972Publication History Published online1 May 2002Published inissue 1 December 1972https://pubs.acs.org/doi/10.1021/jo00797a046https://doi.org/10.1021/jo00797a046research-articleACS PublicationsRequest reuse permissionsArticle Views983Altmetric-Citations38LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Molecular Analysis of SNAP‐25 Function in Exocytosis (2002)

It is generally accepted that the SNARE proteins form the core of the machinery for intracellular membrane fusion and that formation of a SNARE complex is crucially important. Our aim is to dissect the molecular roles of the SNARE proteins and their regulators in physiological membrane fusion during exocytosis. We have developed approaches that allow us to manipulate protein expression in model secretory cells, PC12 and adrenal chromaffin cells, and to combine this with assay of exocytosis at high-time resolution using carbon-fiber amperometry. This technique allows us to assess the extent of exocytosis and to follow the kinetics of single secretory granule release events with millisecond time resolution. We established that manipulation of proteins involved in the exocytotic machinery can lead to detectable and interpretable changes in exocytosis kinetics that have revealed novel roles in late stages of exocytosis. Using this approach we have begun to analyze the function of SNAP-25B using a mutant resistant to the Clostridial neurotoxin BoNT/E. This SNAP-25 mutant can reconstitute exocytosis in BoNT/E-treated cells. With this construct it is possible to analyze the consequences of any introduced mutation in the absence of functional endogenous protein. We review here its use in the analysis of palmitoylated cysteines of SNAP-25 and the conserved residues of the 0 layer of the SNARE complex. The data suggest an important role of the cysteines, but not the 0 layer glutamines, in triggered exocytosis.
The Effect of Temperature on the Proteome of Recombinant <i>Pichia pastoris</i> (2009)

The impact of environmental factors on the productivity of yeast cells is poorly investigated so far. Therefore, it is a major concern to improve the understanding of cellular physiology of microbial protein production hosts, including the methylotrophic yeast Pichia pastoris. Two-Dimensional Fluorescence Difference Gel electrophoresis and protein identification via mass spectrometry were applied to analyze the impact of cultivation temperature on the physiology of a heterologous protein secreting P. pastoris strain. Furthermore, specific productivity was monitored and fluxes through the central carbon metabolism were calculated. Chemostat culture conditions were applied to assess the adaption to different growth temperatures (20, 25, 30 °C) at steady-state conditions. Many important cellular processes, including the central carbon metabolism, stress response and protein folding are affected by changing the growth temperature. A 3-fold increased specific productivity at lower cultivation temperature for an antibody Fab fragment was accompanied by a reduced flux through the TCA-cycle, reduced levels of proteins involved in oxidative stress response and lower cellular levels of molecular chaperones. These data indicate that folding stress is generally decreased at lower cultivation temperatures, enabling more efficient heterologous protein secretion in P. pastoris host cells.