gebhart/patrepeval huggingface dataset:
Dihydropyrimidine calcium channel blockers. II. 3-Substituted-4-aryl-1,4-dihydro-6-methyl-5-pyrimidinecarboxylic acid esters as potent mimics of dihydropyridines (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDihydropyrimidine calcium channel blockers. II. 3-Substituted-4-aryl-1,4-dihydro-6-methyl-5-pyrimidinecarboxylic acid esters as potent mimics of dihydropyridinesKarnail S. Atwal, George C. Rovnyak, S. David Kimball, David M. Floyd, Suzanne Moreland, Brian N. Swanson, Jack Z. Gougoutas, Joseph Schwartz, Kaye M. Smillie, and Mary F. MalleyCite this: J. Med. Chem. 1990, 33, 9, 2629–2635Publication Date (Print):September 1, 1990Publication History Published online1 May 2002Published inissue 1 September 1990https://pubs.acs.org/doi/10.1021/jm00171a044https://doi.org/10.1021/jm00171a044research-articleACS PublicationsRequest reuse permissionsArticle Views825Altmetric-Citations345LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Appetite and Energy Intake Responses to Acute Energy Deficits in Females versus Males (2015)

Women exhibit compensatory appetite, gut hormone, and food intake responses to acute energy restriction but not in response to an acute bout of exercise. Additionally, men and women seem to exhibit similar acylated ghrelin and PYY3-36 responses to exercise-induced energy deficits. These findings advance understanding regarding the interaction between exercise and energy homeostasis in women.
Spectral analysis of an acoustic respiratory signal with a view to developing an apnoea monitor. (1996)

The movement of air through the air passages during normal respiration generates an acoustic signal which can be detected from the surface of the body at suitable sites with the aid of a microphone applied to the skin. The spectral characteristics of these sounds were analysed to see if they could be differentiated from other sources of sound. During normal respiration the other major source of sound was that transmitted from the heart, and this could be filtered out with a band pass filter. A prototype apnoea monitor was built which utilised these sound signals as an indicator of respiration and underwent preliminary testing. Although such acoustic signals have the potential to indicate respiration, and cardiac sounds can be effectively filtered, further work would be required to recognise and reject other extraneous sources of sound interfering with the respiratory signal.
Topology aware overlay networks (2005)

Recently, overlay networks have emerged as a means to enhance end-to-end application performance and availability. Overlay networks attempt to leverage the inherent redundancy of the Internet's underlying routing infrastructure to detour packets along an alternate path when the given primary path becomes unavailable or suffers from congestion. However, the effectiveness of these overlay networks depends on the natural diversity of overlay paths between two endhosts in terms of physical links, routing infrastructure, administrative control, and geographical distribution. Several recent studies realized that a measurable number of path outages were unavoidable even with use of such overlay networks. This stems from the fact that overlay paths might overlap with each other when overlay nodes are selected without considering the underlying topology. An overlay network's ability to quickly recover from path outages and congestion is limited unless we ensure path independence at the IP layer. This paper proposes a novel framework for topology-aware overlay networks. In this framework, we expressly design overlay networks, aiming to maximize path independence without degrading performance. We develop measurement-based heuristics for 1) placement of overlay nodes inside an ISP and 2) selection of a set of ISPs. We base our analysis on extensive data collection from 232 points in 10 ISPs, and 100 PlanetLab nodes. On top of node placement, we present measurement-based verification to conclude that single-hop overlay routing performs as well as multi-hop routing with respect to both availability and performance. Our analysis results show that a single-hop overlay path provides the same degree of path diversity as the multi-hop overlay path for more than 90% of source and destination pairs. Finally, we validate the proposed framework using real Internet outages to show that our architecture is able to provide a significant amount of resilience to real-world failures.
Synthesis of carbon‐13 labelled 6‐substituted benzo (a) pyrenes (1976)

Abstract Sodium formate‐ 13 C, prepared by hydrolysis of isopropyl formate, was allowed to react with N‐methylaniline hydrochloride to prepare the formylating agent N‐methylformanilide‐1‐ 13 C. Formylation of benzo( a )pyrene with N‐methylformanilide‐1‐ 13 C gave the 6‐ 13 CHO derivative which was reduced to 6‐ 13 CH 3 and 6‐ 13 CH 2 OH benzo( a )pyrenes. 6‐ 13 CH 2 C1 benzo( a )pyrene was prepared from the 6‐ 13 CH 2 OH derivative.
Multifunctional Whisker Arrays for Distance Detection, Terrain Mapping, and Object Feature Extraction (2006)

Several species of animals use whiskers to accurately navigate and explore objects in the absence of vision. We have developed inexpensive arrays of artificial whiskers based on strain-gage and Flex Sensor technologies that can be used either in passive (“dragging”) mode, or in active (“whisking”) mode. In the present work we explore the range of functions that whisker arrays can serve on a rover. We demonstrate that when mounted on a rover, whisker arrays can (1) Detect obstacles and determine obstacle distance (2) Map terrain features (3) Determine ground and surface texture (4) Provide an estimate of rover speed (5) Identify “slip” of the rover wheels, and (6) Perform 3-dimensional extraction of object shape. We discuss the potential use of whisker arrays on planetary rovers and as an investigative tool for exploring the encoding of sensory information in the nervous system of animals.
Perceptions Regarding Male Suicide and Preventative Services in Co. Kilkenny (2005)

This paper examines perceptions regarding rural male suicide and the preventative services available in Co. Kilkenny to combat the problem. For every four male suicides, there is one female suicide. The problem is becoming a rural rather than an urban one. The research set out to identify gaps in services and existing policies in addressing suicide among young rural men. Data were obtained from interview with the service providers and also from focus group discussions with young rural Kilkenny men. Total participants in the focus groups were 15 young men. Limitations to this study centred around the difficulty of organising young men to take part in the focus discussion groups. Many official organisations in Co. Kilkenny were approached but no focus group was forthcoming. The one official group that took part was through Macra na Feirme. The other three focus groups that were gathered came from personal contacts. However, even through these channels many potential groups in the end did not materialise and for the groups that did materialise many of the young men did not turn up. Overall the general feedback from people in their resistance to coming together was that the topic was a deterrent to them. The research shows that none of the service providers have a specific focus on the problem of suicide among young rural males and that a National Prevention Strategy is yet to be presented by the National Task Force on Suicide. The prevention services available at the moment are not seen as relevant to young men. They need to become more acceptable especially to those in the high-risk categories. More research needs to be conducted to find the reasons why young rural men are committing suicide so that suitable service responses can be created.
Superconductivity in the Ladder Material Sr<sub>0.4</sub>Ca<sub>13.6</sub>Cu<sub>24</sub>O<sub>41.84</sub> (1996)

We have observed superconductivity in the ladder material Sr 0.4 Ca 13.6 Cu 24 O 41.84 under pressures of 3 GPa and 4.5 GPa by means of electrical measurements. The superconducting transition temperatures T c (onset) are 12 K and 9 K at 3 and 4.5 GPa, respectively. The superconducting volume fraction was obtained to be about 5% from magnetization measurement under 3.5 GPa at 4.2 K, indicating the bulk nature of the superconductivity in this system.
Temperature dependency of optical properties of thermochromic materials. (1997)

温度と共に色を変化させる“サーモクロミック物質”について，物質の温度とその色光の相関を定量的に測定した．試料温度のコントロールと色光の測定が，同時に可能な実験装置を製作した．色光の定量化に分光測光器を用いた．測定した試料は３種類で，温度と共に発光強度が変化する有機系蛍光体，金属錯体溶液，および，典型的なサーモクロミック物質であるカイラルネマチック液晶である．その結果，それぞれの試料において，試料の温度とその分光分布曲線の関係は特徴的に変化した．更に，測定した分光特性から，それぞれの試料の変色を定量的に表現しうる変色パラメータを定めた．これによって，試料の変色を温度と変色パラメータの相関として整理した．今回用いた試料は，温度と変色パラメータの問に明確な相関があり，これらの物質を応用した温度測定法が開発可能なことが示唆された．
Restoration of arbitrary finite-energy optical objects from limited spatial and spectral information (1981)

The mathematical generalization of image restoration by recursive methods furnished by D. C. Youla [ IEEE Trans. Circuits Syst.CAS 25, 695– 702 ( 1978)] is used to show that arbitrary L2 (i.e., square-integrable) images can be reconstructed from two projections without any a priori assumption regarding the mathematical properties of the object, such as space-limitedness or band-limitedness. Recursive algorithms are given to restore images from (1) extended segments and low-pass spectra and (2) short segments and high-pass spectra. Using the alternating projection theorem, we prove monotonic convergence (in the norm) to the original image.
Strategies for Fast‐Switching in All‐Polymer Field Effect Transistors (2014)

Low‐cost printable field effect transistors (FETs) are typically associated with slow switching characteristics. Dynamic response of polymer field effect transistors (PFETs) is a manifestation of time scales involved in processes such as dielectric polarization, structural relaxation, and transport via disordered‐interfacial states. A range of dielectrics and semiconductors are studied to arrive at a parameter which serves as a figure of merit and quantifies the different processes contributing to the switching response. A cross‐over from transport limiting factors to dielectric limiting factors in the dynamics of PFETs is observed. The dielectric limited regime in the PFET dynamics is tapped in to explore high speed processes, and an enhancement of switching speed by three orders of magnitude (from 300 μs to 400 ns) is observed at channel lengths which can be accessed by low cost printing methods. The device structure utilizes polymer‐ferroelectrics (FE) as the dielectric layer and involves a fabrication‐procedure which assists in circumventing the slow dynamics within the bulk of FE. This method of enhancing the dynamic response of PFETs is universally applicable to all classes of disordered‐FE.
Lineage-specific enhancers activate self-renewal genes in macrophages and embryonic stem cells (2016)

Differentiated macrophages can self-renew in tissues and expand long term in culture, but the gene regulatory mechanisms that accomplish self-renewal in the differentiated state have remained unknown. Here we show that in mice, the transcription factors MafB and c-Maf repress a macrophage-specific enhancer repertoire associated with a gene network that controls self-renewal. Single-cell analysis revealed that, in vivo, proliferating resident macrophages can access this network by transient down-regulation of Maf transcription factors. The network also controls embryonic stem cell self-renewal but is associated with distinct embryonic stem cell-specific enhancers. This indicates that distinct lineage-specific enhancer platforms regulate a shared network of genes that control self-renewal potential in both stem and mature cells.
Cancer-Derived Exosomes as Effectors of Key Inflammation-Related Players (2019)

Exosomes, a category of small lipid bilayer extracellular vesicles that are naturally secreted by many cells (both healthy and diseased), carry cargo made up of proteins, lipids, DNAs, and RNAs; all of which are functional when transferred to their recipient cells. Numerous studies have demonstrated the powerful role that exosomes play in the mediation of cell-to-cell communication to induce a pro-tumoral environment to encourage tumor progression and survival. Recently, considerable interest has developed in regard to the role that exosomes play in immunity; with studies demonstrating the ability of exosomes to either metabolically alter immune players such as dendritic cells, T cells, macrophages, and natural killer cells. In this review, we summarize the recent literature on the function of exosomes in regulating a key process that has long been associated with the progression of cancer-inflammation and immunity.
Modular Covalent Multifunctionalization of Copolymers (2007)

Poly(norbornene)-based random copolymers possessing either azide, aldehyde, or ketone functionalities on each repeating unit were synthesized using ring-opening metathesis polymerization. The orthogonal functionalization of the resulting copolymers using 1,3-dipolar cycloadditions and hydrazone formations was investigated. While the azide- and aldehyde-containing copolymers were insoluble in organic solvents, the azide- and ketone-functionalized copolymers were fully soluble in common solvents such as CH2Cl2, THF, and DMF and can be quantitatively functionalized with a library of small organic and biological molecules in a stepwise fashion. The orthogonal functionalization of the ketone/azide copolymers was characterized by NMR and IR spectroscopies and gel-permeation chromatography. A one-pot dual functionalization strategy is also presented that allows for the quantitative dual functionalization of copolymers. This one-pot strategy introduced herein for the preparation of multifunctional macromolecules provides a modular platform for potential applications ranging from electronic materials to polymer-mediated drug delivery.
Degradation of 3-Phenoxybenzoic Acid in Soil by <i>Pseudomonas pseudoalcaligenes</i> POB310(pPOB) and Two Modified <i>Pseudomonas</i> Strains (1999)

Pseudomonas pseudoalcaligenes POB310(pPOB) and Pseudomonas sp. strains B13-D5(pD30.9) and B13-ST1(pPOB) were introduced into soil microcosms containing 3-phenoxybenzoic acid (3-POB) in order to evaluate and compare bacterial survival, degradation of 3-POB, and transfer of plasmids to a recipient bacterium. Strain POB310 was isolated for its ability to use 3-POB as a growth substrate; degradation is initiated by POB-dioxygenase, an enzyme encoded on pPOB. Strain B13-D5 contains pD30.9, a cloning vector harboring the genes encoding POB-dioxygenase; strain B13-ST1 contains pPOB. Degradation of 3-POB in soil by strain POB310 was incomplete, and bacterial densities decreased even under the most favorable conditions (100 ppm of 3-POB, supplementation with P and N, and soil water-holding capacity of 90%). Strains B13-D5 and B13-ST1 degraded 3-POB (10 to 100 ppm) to concentrations of <50 ppb with concomitant increases in density from 10(6) to 10(8) CFU/g (dry weight) of soil. Thus, in contrast to strain POB310, the modified strains had the following two features that are important for in situ bioremediation: survival in soil and growth concurrent with removal of an environmental contaminant. Strains B13-D5 and B13-ST1 also completely degraded 3-POB when the inoculum was only 30 CFU/g (dry weight) of soil. This suggests that in situ bioremediation may be effected, in some cases, with low densities of introduced bacteria. In pure culture, transfer of pPOB from strains POB310 and B13-ST1 to Pseudomonas sp. strain B13 occurred at frequencies of 5 x 10(-7) and 10(-1) transconjugant per donor, respectively. Transfer of pPOB from strain B13-ST1 to strain B13 was observed in autoclaved soil but not in nonautoclaved soil; formation of transconjugant bacteria was more rapid in soil containing clay and organic matter than in sandy soil. Transfer of pPOB from strain POB310 to strain B13 in soil was never observed.
Bilirubin adsorption property of mesoporous silica and amine-grafted mesoporous silica (2010)

Nephritic, hepatic and immune failures would lead to the overload of endogenous toxic molecules (e.g. bilirubin, cholic acid, uric acid, creatinine etc.) in human bodies. It is fatal in most cases and extracorporeal blood purification (ECBP) is powerful first-aid therapy. Adsorbents are key parts of ECBP apparatus. Mesoporous silicas should be promising candidates for these medical adsorbents, but there is no report about this. Herein, pure and amine-grafted mesoporous silicas have been applied to adsorb bilirubin, cholic acid, uric acid, creatinine and phenobarbital for the first time. These mesoporous materials show high adsorption capacities for bilirubin and uric acid in phosphate buffer solution (PBS). Effects of pore sizes, amine-modification, temperature and ionic strength on their bilirubin adsorption capacities have been studied in detail.
Nickel Film Deposition with Varying RF Power for the Reduction of Contact Resistance in NiSi (2019)

In this study, the effect of radio frequency (RF) power on nickel (Ni) film deposition was studied to investigate the applications of lowering the contact resistance in the NiSi/Si junction. The RF powers of 100, 150, and 200 W were used for the deposition of the Ni film on an n/p silicon substrate. RMS roughnesses of 1.354, 1.174 and 1.338 nm were obtained at 100, 150, and 200 W, respectively. A circular transmission line model (CTLM) pattern was used to obtain the contact resistance for three different RF-power-deposited films. The lowest contact resistivity of 5.84 × 10−5 Ω-cm2 was obtained for the NiSi/n-Si substrate for Ni film deposited at 150 W RF power.
Calculation of photostationary states in systems A .dblarw. B when only A is known (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCalculation of photostationary states in systems A .dblarw. B when only A is knownErnst FischerCite this: J. Phys. Chem. 1967, 71, 11, 3704–3706Publication Date (Print):October 1, 1967Publication History Published online1 May 2002Published inissue 1 October 1967https://pubs.acs.org/doi/10.1021/j100870a063https://doi.org/10.1021/j100870a063research-articleACS PublicationsRequest reuse permissionsArticle Views1569Altmetric-Citations242LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Variational Iterative Methods for Nonsymmetric Systems of Linear Equations (1983)

We consider a class of iterative algorithms for solving systems of linear equations where the coefficient matrix is nonsymmetric with positive-definite symmetric part. The algorithms are modelled after the conjugate gradient method, and are well suited for large sparse systems. They do not make use of any associated symmetric problems. Convergence results and error bounds are presented.
<b>The 12/23 rule is enforced at the cleavage step of V(D)J recombination <i>in vivo</i></b> (1996)

These results suggest that the 12/23 rule is enforced at or prior to cleavage and support a synapsis model for V(D)J recombination. Detection of rare cleavage events in substrates containing a single RSS or a pair of RSS with the same spacer length provide evidence for an inefficient, single RSS cleavage pathway that may contribute to aberrant V(D)J rearrangements in vivo.
Application of computer-assisted navigation systems in oral and maxillofacial surgery (2018)

The oral and maxillofacial region has a complicated anatomy with critical contiguous organs, including the brain, eyes, vital teeth, and complex networks of nerves and blood vessels. Therefore, advances in basic scientific research within the field of intraoperative oral and maxillofacial surgery have enabled the introduction of the features of these techniques into routine clinical practice to ensure safe and reliable surgery. A navigation system provides a useful guide for safer and more accurate complex in oral and maxillofacial surgery. The effectiveness of a navigation system for oral and maxillofacial surgery has been indicated by clinical applications in maxillofacial trauma surgery including complex midfacial fractures and orbital trauma reconstruction, foreign body removal, complex dentoalveolar surgery, skull base surgery including surgery of the temporomandibular joint (TMJ), and orthognathic surgery. However, some fundamental issues remain involving the mobility of the mandible and difficulty in updating images intraoperatively. This report presents an overview and feasible applications of available navigation systems with a focus on the clinical feasibility of the application of navigation systems in the field of oral and maxillofacial surgery and solutions to current problems.
Prototyping SIP-based VoIP services in Java (2002)

Next to the binary-based H.323 signaling protocol for IP telephony developed by the telecommunication community (ITU-T), a more lightweight text-based protocol was deemed necessary to address the specific needs of the Internet community. The session initiation protocol (SIP) (see Handley, M. et al., IETF-RFC 2543, March 1999) was introduced in the IETF conference control working group and has meanwhile gained maturity and support. This paper presents a Java-based implementation of the SIP protocol stack, based on a layered SW architecture, reusable object oriented software components and application programming interfaces (API). This protocol stack has been used as a basis to realize the main network components necessary for SIP based call setup: user agent, proxy server, redirect server, and registration server. The interaction between these components is illustrated through a number of service scenarios, focusing on PC-to-PC communication within the context of a virtual private network (VPN) service.
The clinicopathological significance of Mortalin overexpression in invasive ductal carcinoma of breast (2016)

Mortalin is upregulated in breast cancer, and may be a useful poor prognostic biomarker as well as a potential therapeutic target for patients with breast cancer.