gebhart/patrepeval huggingface dataset:
Measures of Healthspan as Indices of Aging in Mice—A Recommendation (2015)

Over the past decade, a large number of discoveries have shown that interventions (genetic, pharmacological, and nutritional) increase the lifespan of invertebrates and laboratory rodents. Therefore, the possibility of developing antiaging interventions for humans has gone from a dream to a reality. However, it has also become apparent that we need more information than just lifespan to evaluate the translational potential of any proposed antiaging intervention to humans. Information is needed on how an intervention alters the "healthspan" of an animal, that is, how the physiological functions that change with age are altered. In this report, we describe the utility and the limitations of assays in mice currently available for measuring a wide range of physiological functions that potentially impact quality of life. We encourage investigators and reviewers alike to expect at minimum an overall assessment of health in several domains across several ages before an intervention is labeled as "increasing healthspan." In addition, it is important that investigators indicate any tests in which the treated group did worse or did not differ statistically from controls because overall health is a complex phenotype, and no intervention discovered to date improves every aspect of health. Finally, we strongly recommend that functional measurements be performed in both males and females so that sex differences in the rate of functional decline in different domains are taken into consideration.
Multiresolution MR elastography using nonlinear inversion (2012)

Multiresolution NLI elastography provides a more flexible framework for mechanical property estimation compared to previous single mesh implementations.
Genetic susceptibility to chlamydial salpingitis and subsequent infertility in mice (1992)

Groups of mice from genetically defined inbred strains were infected genitally with a pathogenic human strain of Chlamydia trachomatis and their subsequent fertility was compared. The CBA, C3H (H-2o) and C3H/He-mg (H-2k) mice were less fertile than control mice, at least up to 6 months after infection. In contrast, fertility was not impaired in BALB/c mice or in congenic BALB/K mice, which had the H-2k haplotype. Reduced fertility was paralleled by the extent of histological oviductal inflammation in mice of each strain. No salpingitis was seen 21 days after infection in the BALB strains, but lesions were apparent in CBA and C3H strains up to about 70 days after inoculation and these sometimes developed into hydrosalpinges. These results indicate that susceptibility to chlamydial salpingitis and subsequent infertility is under genetic control. This control was not simply associated with the major H-2 gene complex, as mouse strains of the same haplotype (H-2k) differed in susceptibility. The fertility of BALB/c (H-2d) and BALB/K (H-2k) strains was no different from that of controls, and congenic C3H mice of differing H-2 haplotypes (H-2k and H-2o) showed reduced fertility. Although all the infected F1 (BALB/K x C3H/He-mg) mice produced litters at the same rate as untreated controls, the litters were considerably smaller. This was due to the occurrence of unilateral pregnancies in the mice inoculated under the ovarian bursae and possibly also to early fetal death in mice inoculated directly in the uterus. These findings emphasize the importance of early diagnosis and treatment of infection of the lower genital tract of women.
Distinct effects of pitavastatin and atorvastatin on lipoprotein subclasses in patients with Type 2 diabetes mellitus (2011)

The impact on lipoprotein subclass profiles was different between pitavastatin and atorvastatin. It may be beneficial to determine lipoprotein subclass profile and select the appropriate statin for each profile in patients with diabetes with an additional cardiovascular risk such as low HDL cholesterol or hypertriglyceridaemia.
DP-CGAN: Differentially Private Synthetic Data and Label Generation (2019)

Generative Adversarial Networks (GANs) are one of the well-known models to generate synthetic data including images, especially for research communities that cannot use original sensitive datasets because they are not publicly accessible. One of the main challenges in this area is to preserve the privacy of individuals who participate in the training of the GAN models. To address this challenge, we introduce a Differentially Private Conditional GAN (DP-CGAN) training framework based on a new clipping and perturbation strategy, which improves the performance of the model while preserving privacy of the training dataset. DP-CGAN generates both synthetic data and corresponding labels and leverages the recently introduced Renyi differential privacy accountant to track the spent privacy budget. The experimental results show that DP-CGAN can generate visually and empirically promising results on the MNIST dataset with a single-digit epsilon parameter in differential privacy.
Insertions of unactivated olefins into the hydrosulfido ligand of a cationic cyclopentadienylmolybdenum complex (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInsertions of unactivated olefins into the hydrosulfido ligand of a cationic cyclopentadienylmolybdenum complexJ. Birnbaum, J. C. V. Laurie, and M. Rakowski DuBoisCite this: Organometallics 1990, 9, 1, 156–164Publication Date (Print):January 1, 1990Publication History Published online1 May 2002Published inissue 1 January 1990https://pubs.acs.org/doi/10.1021/om00115a025https://doi.org/10.1021/om00115a025research-articleACS PublicationsRequest reuse permissionsArticle Views67Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Some Notes on the Character of Bell Tones (1933)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation A. N. Curtiss, G. M. Giannini; Some Notes on the Character of Bell Tones. J. Acoust. Soc. Am. 1 October 1933; 5 (2): 159–166. https://doi.org/10.1121/1.1915644 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAcoustical Society of AmericaThe Journal of the Acoustical Society of America Search Advanced Search |Citation Search
Research Progress of Anode Material LiV_3O_8 for Aqueous Lithium-ion Battery (2012)

The structural characteristics and charge-discharge mechanism of lithium vanadium oxides Li1+xV3O8 as anode material used in aqueous lithium-ion battery were introduced.The electrochemical performance of lithium vanadium oxides LiV3O8 for aqueous lithium-ion battery was emphasized.And the development prospect of LiV3O8 anode material was pointed out.
Design of a binary-weighted resistor DAC using tunable linearized floating-gate CMOS resistors (2006)

We present an implementation of a 4-bit binary-weighted-resistor DAC to be used in quantizers. It is built by using tunable floating-gate CMOS resistors, which exploit the capacitive coupling and voltage storage capabilities of floating-gate transistors and employ scaled-gate linearization technique to suppress the MOSFET nonlinearities. The resistance of these resistors drifts 1.6 middot 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-3</sup> % over the period of 10 years at 25degC. By using these resistors, 15-bit accurate DAC is implemented in 0.5mum CMOS process
A new paper/computer interface: two-dimensional symbologies (2002)

Two-dimensional symbologies have been around for a while but they did not reach the broad public until the last few years. Examples include the "bull's eye" code that appears in all United Parcel Service packages and the two-dimensional bar code PDF417 that appears in driver's licenses in several states, metered postage, and identity documents. The paper covers the basic principles of the design of such codes, problems associated with their reading, and examples of applications. It also reviews how such symbologies are related to OCR-based document reading and how the technologies can supplement each other.
Development of Highly Soluble Anthraquinone Dichroic Dyes and Their Application to Three-Layer Guest-Host Liquid Crystal Displays (2009)

The relationships between molecular structures and properties of anthraquinone dichroic dyes were studied and dyes with large solubilities and dichroic ratios were developed. The yellow anthraquinone dye behaves as a quencher of the coumarin dye, and the mixture has a large absorption coefficient without fluorescence. These technologies can enlarge the color reproduction area of three-layer guest-host liquid crystal displays (GHLCDs) 1.6-fold. The performances of the prototype reflective three-layer GH-LCDs are as follows: the white state luminous reflectance is 43% and the contrast is 5.3, indicating that they are promising candidates for portable information systems with full-color images.
An accurate preprocessor for Monte Carlo study of electron transport in inversion layers of silicon nMOSFETs (2002)

Summary form only given. For a typical device simulation one cannot ignore the presence of nonuniformity in realistic MOSFET inversion layers. In this case, computationally demanding Schrodinger-MC-Poisson iteration (SMCPT) seems to be the only viable methodology. In this paper, we present an alternative approach that efficiently includes the quantization effect in the drift-diffusion preprocessing step such that the transport characteristics can be accurately captured without using a SMCPT. For this purpose, PISCES has been chosen as the preprocessor, allowing channel quantization effects to be ignored or treated with either of two models: the 3-subband model (3SB) and the van Dort model.
Role of Carboxylesterase in Soman, Sarin and Tabun Poisoning in Rats (1989)

TOCP (triorthocresyl phosphate) inhibits carboxylesterase (CarbE) activity in rat plasma and liver and significantly increases soman, sarin and tabun toxicity. Application of these agents after TOCP caused strong additional inhibition of CarbE and cholinesterases (ChE) in rat red blood cells, plasma, liver, brain, diaphragm and intercostal muscle. After phenobarbital pretreatment, which induced CarbE activity in plasma and liver by 80% and that of plasma ChE by 33%, acute toxicity of soman and tabun was greatly decreased, while that of sarin remained unaffected.
Engineering furfural tolerance in <i>Escherichia coli</i> improves the fermentation of lignocellulosic sugars into renewable chemicals (2013)

Pretreatments such as dilute acid at elevated temperature are effective for the hydrolysis of pentose polymers in hemicellulose and also increase the access of enzymes to cellulose fibers. However, the fermentation of resulting syrups is hindered by minor reaction products such as furfural from pentose dehydration. To mitigate this problem, four genetic traits have been identified that increase furfural tolerance in ethanol-producing Escherichia coli LY180 (strain W derivative): increased expression of fucO, ucpA, or pntAB and deletion of yqhD. Plasmids and integrated strains were used to characterize epistatic interactions among traits and to identify the most effective combinations. Furfural resistance traits were subsequently integrated into the chromosome of LY180 to construct strain XW129 (LY180 ΔyqhD ackA::PyadC'fucO-ucpA) for ethanol. This same combination of traits was also constructed in succinate biocatalysts (Escherichia coli strain C derivatives) and found to increase furfural tolerance. Strains engineered for resistance to furfural were also more resistant to the mixture of inhibitors in hemicellulose hydrolysates, confirming the importance of furfural as an inhibitory component. With resistant biocatalysts, product yields (ethanol and succinate) from hemicellulose syrups were equal to control fermentations in laboratory media without inhibitors. The combination of genetic traits identified for the production of ethanol (strain W derivative) and succinate (strain C derivative) may prove useful for other renewable chemicals from lignocellulosic sugars.
Extended thymus action for improving response of AIS based NID system against malicious traffic (2007)

Artificial immune systems (AISs) are being increasingly utilized to develop network intrusion detection (NID) systems. The fundamental reason for their success in NID is their ability to learn normal behavior of a network system and then differentiate it from an anomalous behavior. As a result, they can detect a majority of innovative attacks. In comparison, classical signature based systems fail to detect innovative attacks. Light Weight Intrusion Detection System (LISYS) provides the basic framework for AIS based NID systems. This framework has been improved incrementally, including incorporation of thymus action, since it was first developed. In this paper, we have extended the basic thymus action model, which provides immature detectors with multiple chances to develop tolerization to normal. However, AIS is prone to successful attacks by malicious traffic which appears similar to the normal traffic. This results in high number of false positives. In this paper, we present a mathematical model of malicious traffic for TCP-SYN flood based distributed denial of services (DDoS) attacks. This model is used to generate different sets of malicious traffic. These sets are used for performance comparison of the proposed extended thymus action with the simple thymus action model. The results of our experiments demonstrate that the extended model has significantly reduced the number of false positives.
Stat5 Synergizes with T Cell Receptor/Antigen Stimulation in the Development of Lymphoblastic Lymphoma (2003)

Signal transducer and activator of transcription (STAT) proteins are latent transcription factors that mediate a wide range of actions induced by cytokines, interferons, and growth factors. We now report the development of thymic T cell lymphoblastic lymphomas in transgenic mice in which Stat5a or Stat5b is overexpressed within the lymphoid compartment. The rate of lymphoma induction was markedly enhanced by immunization or by the introduction of TCR transgenes. Remarkably, the Stat5 transgene potently induced development of CD8+ T cells, even in mice expressing a class II-restricted TCR transgene, with resulting CD8+ T cell lymphomas. These data demonstrate the oncogenic potential of dysregulated expression of a STAT protein that is not constitutively activated, and that TCR stimulation can contribute to this process.
Improving performance and reliability of an IMS network by co-locating IMS servers (2006)

The IP Multimedia Subsystem (IMS) is an architecture for supporting multimedia services via a Session Initiation Protocol (SIP) infrastructure. IMS, specified by the 3rd Generation Partnership Project (3GPP), is increasingly adopted as the reference multimedia network architecture by providers of wireline and wireless infrastructure and associated multimedia application services. One of the characteristics of the IMS architecture is that many different and mandatory SIP proxies are used for each end-to-end SIP session. This may adversely impact the overall IMS call processing performance, which is already affected by the universal usage of SIP. This also makes each end-to-end SIP session dependent on the good functioning of many hosts, which decreases reliability while increasing significantly the end-to-end message latency. This paper analyzes the performance and quantifies the benefits of having the SIP servers running on the same host. It then explains which types of SIP calls in the IMS network can benefit from the co-location of IMS servers and shows how to design the IMS network to maximize IMS server co-location. Finally, it introduces Lucent Technologies' SIPia BUS software architecture, which implements the co-location capability by introducing a new SIP transport in a way that is both natural and non-disruptive for the SIP stack and the SIP user agent.
Research on the Mechanism of Action of Transactive Memory System in Engineering Project Teams (2014)

Along with the intensification of market competition, using a system based on team work to improve team performance got the most enterprises' attention. A transactive memory system explains a mechanism of team knowledge processing - a kind of division of cooperation system formed between team members depending on each other to encode, store and extract different domain knowledge. The research helps to find information needed by an efficient working team to solve problems and explain how the team members play to their expertise to solve the problem facing the team. This paper begins with the formation and maintenance of a transactive memory system, measurement, influence factors and how to improve the team performance. It is combined with the characteristics of the engineering project and the engineering project team and built effectiveness model of the engineering project team based on a transactive memory system to explore the meaning of transactive memory system as applied in the engineering project team.
Thin-Film Fluid Flows over Microdecorated Surfaces: Observation of Polygonal Hydraulic Jumps (2009)

Liquid films flowing over rough substrates are influenced by asperities whose sizes are comparable to the film thickness. We investigate flows driven by jet impact on a regular array of micron-size posts. We show that the topography modifies the size and the shape of the observed hydraulic jumps: in addition to circular jumps, we obtain a variety of stable polygonal shapes. We rationalize our results by considering a leakage flow through the texture and the free-surface flow above it, coupled by an effective slip boundary condition accounting for the symmetry of the texture. This model is in good agreement with our experiments and allows us to account for the interplay between flow properties and roughness parameters, which has applicability in many other thin-film configurations.
Reducing Proximity Effects in Optical Lithography (1996)

Using simulation, the influence of stepper parameters on optical proximity effects is explored. In particular, numerical aperture and partial coherence will be examined for a variety of feature sizes and types. Both one-dimensional and two-dimensional mask features will be studied. The impact of resist contrast will also be explored. In addition to the iso-dense print bias as a metric of proximity effects, the depth of focus as an overlapping of two focus-exposure process windows, one for the isolated line and one for the dense line, will be used. The optimum NA and σ will give the maximum depth of focus calculated from the overlapped process window. Finally, the statistical CD distribution methodology will be used to find the stepper settings that minimize the linewidth distribution spread for a given process.
Oxidation of Lignin Using Aqueous Polyoxometalates in the Presence of Alcohols (2008)

A novel approach has been developed in order to use Kraft lignin as a renewable resource for the production of chemicals. The concept is based on the use of polyoxometalates as reversible oxidants and on the use of radical scavengers, which prevent lignin fragments from repolymerizing. The oxidation of Kraft lignin, which is a potential source of functionalized phenols, by H3PMo12O40 in water yields a relatively small amount of monomeric species detected by GC-MS. The addition of methanol to the reaction resulted in an increase in the yield of monomeric products by a factor of up to 15. Vanillin and methyl vanillate are the main products obtained, in a maximum yield of 5 wt % based on dry Kraft lignin. Methanol plays a decisive role in the prevention of repolymerization by reducing lignin-lignin condensation reactions. Furthermore, it is proposed that methanol generates small amounts of .CH3 and CH3O. radicals through the acid-catalyzed formation of dimethyl ether which couple with lignin fragments.
Lab-on-a-chip for measuring uric acid in biological fluids (2002)

This paper describes a lab-on-a-chip for measuring uric acid in serum, plasma or urine. The lab-on-a-chip is composed by two dies: one is fabricated in polystyrene and contains the microchannels and the other is fabricated through a CMOS process and contains the photodetector and readout electronics. The uric acid concentration is measured by using a mixture of 14 µl of infinityTM uric acid reagent with 0.25 µl of sample. The achieved sensitivity is 0.33 mg/dl (±0.6% of human being urine values), with a 1 mm lightpath. Using an optical absorption method, a maximum peak at wavelength λ = 494 nm, is detected.
Physiological Effect of Vibrations on Tractor Drivers under Variable Ploughing Conditions (2004)

The vibration conditions to which tractor operators are subjected are complex and varied with multi axis translation and rotational vibration inputs to different parts of the body. Working under such conditions may lead to human fatigue and other driving related hazards. The present research was carried out to study the operators under varying conditions of vibration while driving a tractor with and without farm equipment on different fields. Test runs were conducted in wet and dry fields to determine the levels of vibration generated at different engine speeds. On the basis of this study three levels of vibration namely 2.5, 3.5 and 5.0 m/s(2) were selected. Five subjects, all males, with no experience in the field of tractor driving participated in the study. The data were analyzed on the basis of three factor repeated measure kind of experimental design. The results showed that the main effects of farm equipment and the vibration level were statistically significant but the effect of field type was found to be statistically non-significant. The results of the study call upon the ergonomists to design and develop a tractor where the driver may be relieved of vibration induced stresses. Front loading of farm equipment is recommended for improved visibility and better working posture.