gebhart/patrepeval huggingface dataset:
DARPP-32 expression arises after a phase of dysplasia in oesophageal squamous cell carcinoma (2004)

This is the first report to correlate DARPP-32 immunoreactivity (dopamine and cAMP-regulated phosphoprotein, M(r) 32 000) to clinicopathological status in human cancer. DARPP-32 is recognised as a neuronal protein. A recent study demonstrated that DARPP-32, and a truncated isoform t-DARPP, are overexpressed in gastric carcinoma during the process of carcinogenesis. The biological function of DARPP-32, however, is still unclear. The purpose of this study was to clarify the roles of DARPP-32 and t-DARPP in oesophageal squamous cell carcinoma (OSCC). Initially, we investigated DARPP-32 and t-DARPP expression in OSCC cell lines by Reverse transcription-polymerase chain reaction and Western blot. DARPP-32 expression was observed in four out of seven (57.1%) cell lines, but t-DARPP expression was not observed in any cell lines. In oesophageal tissue sample, DARPP-32 expression was observed in four out of seven (57.1%) tumour tissues, while t-DARPP was not observed in any tissues. Subsequently, DARPP expression was assessed by immunohistochemistry, using a polyclonal antibody, in tissue sections from 122 patients with primary OSCC. DARPP immunoreactivity was not observed in any normal oesophageal mucous membranes. On the other hand, positive DARPP immunostaining was detected in 37 patients (30.3%) and correlated inversely with pathologic stage (P=0.0284), pT (P=0.0438), pN (P=0.0303) and tumour size (P=0.012). The overall survival rate was worse in patients with DARPP-negative tumours than in patients with DARPP-positive tumours (P=0.0453). Interestingly, DARPP expression was observed in only one out of 45 cases of dysplasia. These observations suggest that DARPP-32 (rather than t-DARPP) expression arises after a phase of dysplasia in OSCC, and that tumours expressing DARPP-32 progress less rapidly than DARPP-32-negative tumours.
A digital display processor with integrated 9 bit triple DAC for enhanced TV applications (1993)

A single IC that performs processing and a 9-b digital-to-analog conversion of video component signals is described. It accepts multiple data formats and improves picture quality by luminance peaking, digital chrominance transition improvement, and oversampling techniques. Display format control (4:3, 16:9, etc.) is realized by time compression or expansion. This display processor was implemented in a 1 mu m-CMOS technology with two-layer metallization. The chip has an area of 50.17 mm/sup 2/, containing 179397 transistors.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Software-defined radar and waveforms for studying micro-Doppler signatures (2014)

In this paper, we investigate the use of software defined radar (SDR) to analyze the micro-Doppler signatures. The first SDR we use is based on the Universal Software Radio Peripheral (USRP) and GNU Radio, and another SDR which has several operation modes is based on field-programmable gate arrays (FPGA). Typically, the USRP-based SDR is not optimized for radar applications due to its narrow bandwidth and time-varying additional delay caused by USRP components and operating system. The FPGA-based SDR is more suitable for applications where high-resolution range information is required. Our studies indicate that both of the SDR systems are capable of producing the micro-Doppler signatures. System design challenges and measurement results will be discussed in detail.
Abstract 3966: Targeting integrin αvβ3-expressing cancer stem cells to manipulate tumor-associated macrophages (2017)

Abstract Tumor associated macrophages are involved in regulation of cancer growth and aggressiveness. Whereas M1 macrophages trigger an inflammatory response and inhibit tumor growth, M2 macrophages secrete pro-tumor cytokines into the microenvironment to support tumor progression. A macrophage switch from M1 to M2 has been associated with lung cancer progression, and cancer stem cells have been implicated as a driver of this reprogramming. We recently reported that integrin αvβ3 expression is induced on lung adenocarcinoma cells during drug resistance and is both necessary and sufficient to reprogram these tumors to a stem-like state. Given the role that cancer stem cells play in switching M1 to M2 macrophages, we asked whether αvβ3 expression on lung adenocarcinoma cells account for this macrophage conversion. The M1/M2 macrophage ratio in αvβ3-positive tumors was markedly decreased relative to tumors lacking αvβ3. We next treated mice bearing αvβ3-positive tumors with a monoclonal antibody (LM609) targeting this receptor to assess its ability to alter the macrophage phenotype within these tumors. LM609 was able to selectively eliminate the αvβ3-positive cancer stem cells via antibody-dependent cell-mediated cytotoxicity (ADCC), and this not only increased the M1 macrophage population, but also markedly enhanced the sensitivity of these tumors to the effects of therapy. These findings reveal that αvβ3-expressing cancer stem cells favor the pro-tumor M2 macrophage phenotype. Eliminating αvβ3-positive cancer stem cells via ADCC serves to both increase pro-inflammatory macrophages within the tumor microenvironment and prolong tumor sensitivity to therapy. Citation Format: Hiromi I. Wettersten, Toshiyuki Minami, Megan M. Kaneda, Laetitia Seguin, Judith A. Varner, Sara M. Weis, David A. Cheresh. Targeting integrin αvβ3-expressing cancer stem cells to manipulate tumor-associated macrophages [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 3966. doi:10.1158/1538-7445.AM2017-3966
Quantum Algorithm for Polynomial Root Finding Problem (2014)

Quantum computation is a new computing model based on fundamental quantum mechanical principle. Grover's algorithm finds the solution for a searching problem in the square root time of exhaustive search. Brassard, Hoyer, Tapp's algorithm counts the number of solutions for a searching problem. Through exploiting the two quantum algorithms, we propose a quantum algorithm for solving a new cryptography problem -- polynomial root finding problem, which could be used to design a cryptosystem. The algorithm will take O(rootM/t) steps for finding one of the t solutions to the problem, where M is the modular of the equation. The success rate of the algorithm is a constant and the cost of the algorithm depends on the calculations of modular exponentiation and the number of iterations.
Rigid 3D geometry matching for grasping of known objects in cluttered scenes (2012)

In this paper, we present an efficient 3D object recognition and pose estimation approach for grasping procedures in cluttered and occluded environments. In contrast to common appearance-based approaches, we rely solely on 3D geometry information. Our method is based on a robust geometric descriptor, a hashing technique and an efficient, localized RANSAC-like sampling strategy. We assume that each object is represented by a model consisting of a set of points with corresponding surface normals. Our method simultaneously recognizes multiple model instances and estimates their pose in the scene. A variety of tests shows that the proposed method performs well on noisy, cluttered and unsegmented range scans in which only small parts of the objects are visible. The main procedure of the algorithm has a linear time complexity resulting in a high recognition speed which allows a direct integration of the method into a continuous manipulation task. The experimental validation with a seven-degree-of-freedom Cartesian impedance controlled robot shows how the method can be used for grasping objects from a complex random stack. This application demonstrates how the integration of computer vision and soft-robotics leads to a robotic system capable of acting in unstructured and occluded environments.
Los Alamos KrF laser program (1985)

The KrF laser wavelength has proven to be near optimum for coupling to laser fusion targets. This property along with its scalability to high pulse energy, high pulse repetition frequency, and high efficiency qualifies the laser for serious investigation as a function driver system. The high gain and short upper level lifetime are problems to be solved for giant pulse fusion systems.
Ultrafast magneto-optic sampling of picosecond current pulses (1996)

We report the demonstration of a magneto-optic sampling technique that allows for the detection of picosecond electrical pulses propagating down a microstrip transmission line. A unique feature of the method is that it directly measures the current in ultrashort electrical pulses. The technique is based on time-resolved detection of the magneto-optic Faraday effect in a Bi-substituted yttrium-iron-garnet (Bi-YIG) film. The detailed magnetic response is found to be in excellent agreement with the Bloch-Bloembergen equations. The bandwidth of the sampling system has been demonstrated to scale with the ferromagnetic resonance frequency up to 82.3 GHz, with a potential for increase towards 1 THz.
Conductive Coatings for EMI Shielding (1988)

Types de revetements conducteurs (avec C, Cu, Ni, Ag, etc). Effet d'ecran. Comparaison. Utilisations. Controle de qualite
Review: carbon onions for electrochemical energy storage (2015)

Carbon onions are a relatively new member of the carbon nanomaterials family. They consist of multiple concentric fullerene-like carbon shells which are highly defective and disordered.
Authenticating network attached storage (2000)

We present an architecture for network-authenticated disks that implements distributed file systems without file servers or encryption. Our system provides network clients with direct network access to remote storage.
Design guideline for magnetic integration in LLC resonant converters (2008)

The aim of this paper is to present a comprehensive design methodology for the magnetic integration of the series and shunt inductances of the resonant tank in an LLC resonant converter within the transformer. The design procedure applies to symmetrical core-bobbin structures with two separate slots for the primary and secondary windings. A specific leakage inductance A <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">sigma</sub> . (per square turn) that depends on geometrical parameters only is derived. This is used, together with the cross section and winding area of the core, to define two other core parameters that allow the designer to identify the minimum ferrite core size suitable for the application.
Review of Residential Low-Load HVAC Systems (2013)

In support of the U.S. Department of Energy’s (DOE’s) Building America Program, Pacific Northwest National Laboratory (PNNL) conducted an investigation to inventory commercially available HVAC technologies that are being installed in low-load homes. The first step in this investigation was to conduct a review of published literature to identify low-load HVAC technologies available in the United States and abroad, and document the findings of existing case studies that have evaluated the performance of the identified technologies. This report presents the findings of the literature review, identifies gaps in the literature or technical understanding that must be addressed before low-load HVAC technologies can be fully evaluated, and introduces PNNL’s planned research and analysis for this project to address identified gaps and potential future work on residential low-load HVAC systems.
Blood Products Laboratory (1978)

parison we recorded our results in the same way as Drs Lunn and Johnson.Forty-four of the 60 persons with positive Mantoux tests had a positive and 10 a doubtful tine test.We even found 9",, positive tine tests in Mantoux-negative patients, a fact we explain by the difficulty of strictly intracutane- ous application of the Mantoux test in older persons with very thin skin.In our practice the tine test is an accurate and easily performed screening test for tuberculosis.
A comparison of the cardiovascular and metabolic effects of formoterol, salbutamol and fenoterol (1993)

The cardiovascular and metabolic effects of the long-acting beta 2-agonist formoterol were compared with those of salbutamol, fenoterol and placebo in 12 healthy volunteers, using a randomised, double-blind, cross-over design. On the study days, the subjects inhaled either formoterol (24 micrograms), salbutamol (400 micrograms), fenoterol (400 micrograms) or placebo, at 30 min intervals for five doses. Heart rate (HR) total electromechanical systole (Q-S2I) (a measure of inotropy), the corrected QT interval (QTc), systolic and diastolic blood pressure, plasma glucose and plasma potassium (K+) were measured prior to drug administration, 10 min after each inhalation and at 30 min intervals for 3 h after the last inhalation. All of the active agents significantly increased HR, QTc and plasma glucose, and decreased Q-S2I, diastolic blood pressure and plasma K+ compared to placebo. Fenoterol had a significantly greater maximum effect on HR, QTc and Q-S2I than either salbutamol or formoterol. Formoterol and fenoterol caused a similar maximum reduction in plasma K+, greater than that due to salbutamol. We conclude that formoterol is a more selective beta 2-agonist than fenoterol, and has similar cardiovascular effects to salbutamol when inhaled repeatedly by normal volunteers.
Griffithsin Protects Mice from Genital Herpes by Preventing Cell-to-Cell Spread (2013)

Griffithsin, which binds N-linked glycans on gp120 to prevent HIV entry, has the most potent HIV-1 inhibitory activity described for any antiviral lectin and is being developed for topical preexposure prophylaxis. The current studies were designed to further assess its potential by exploring its activity against herpes simplex virus 2 (HSV-2), a cofactor for HIV acquisition, in vitro and in a murine model. Safety was evaluated by examining its impact on epithelial barrier integrity in polarized cultures and testing whether repeated intravaginal dosing potentiates the susceptibility of mice to genital herpes. Griffithsin displayed modest inhibitory activity against HSV-2 if present during viral entry but completely blocked plaque formation if present postentry, reduced plaque size, and prevented cell-to-cell spread. These in vitro findings translated to significant protection against genital herpes in mice treated with 0.1% griffithsin gel. Griffithsin, but not placebo gel, prevented viral spread (visualized with a luciferase-expressing virus), significantly reduced disease scores, and resulted in greater survival (P < 0.05, log rank test). Protection persisted when HSV-2 was introduced in seminal plasma. Although griffithsin triggered a small decline in transepithelial electrical resistance in polarized cultures, this did not translate to any significant increase in the ability of HIV to migrate from the apical to the basolateral chamber nor to an increase in susceptibility to HSV-2 in mice treated with griffithsin gel for 7 days. These findings demonstrate that griffithsin inhibits HSV-2 by a unique mechanism of blocking cell-to-cell spread and support its further development for HIV and HSV-2 prevention.
Robust multi-object tracking via cross-domain contextual information for sports video analysis (2012)

Multiple player tracking is one of the main building blocks needed in a sports video analysis system. In an uncalibrated camera setting, robust mutli-object tracking can be very difficult due to a number of reasons including the presence of noise, occlusion, fast camera motion, low-resolution image capture, varying viewpoints and illumination changes. To address the problem of multi-object tracking in sports videos, we go beyond the video frame domain and make use of information in a homography transform domain that is denoted the homography field domain. We propose a novel particle filter based tracking algorithm that uses both object appearance information (e.g. color and shape) in the image domain and cross-domain contextual information in the field domain to improve object tracking. In the field domain, the effect of fast camera motion is significantly alleviated since the underlying homography transform from each frame to the field domain can be accurately estimated. We use contextual trajectory information (intra-trajectory and inter-trajectory context) to further improve the prediction of object states within an particle filter framework. Here, intra-trajectory contextual information is based on history tracking results in the field domain, while inter-trajectory contextual information is extracted from a compiled trajectory dataset based on tracks computed from videos depicting the same sport. Experimental results on real world sports data show that our system is able to effectively and robustly track a variable number of targets regardless of background clutter, camera motion and frequent mutual occlusion between targets.
Steam Purity Determination by Tracer Techniques (1957)

The experiences, techniques, and results of both laboratory and field tests in the use of natural sodium and radioactive phosphate (P32) as tracer materials for the determination of steam purity are described. Carry-over results using tracer techniques are compared to those obtained by the standard electrical conductivity method. These tests illustrate that tracers provide extreme sensitivity for measurement of steam purity. Although the use of the radioactive tracer technique is restricted to small scale tests because of excessive costs, the sodium tracer technique appears to offer a promising method for measuring mechanical carry-over in industrial applications.
Reduction of Hg(II) to Hg(0) by Magnetite (2009)

Mercury (Hg) is a highly toxic element, and its contamination of groundwater presents a significant threat to terrestrial ecosystems. Understanding the geochemical processes that mediate mercury transformations in the subsurface is necessary to predict its fate and transport. In this study, we investigated the redox transformation of mercuric Hg (Hg[II]) in the presence of the Fe(II)/Fe(III) mixed valence iron oxide mineral magnetite. Kinetic and spectroscopic experiments were performed to elucidate reaction rates and mechanisms. The experimental data demonstrated that reaction of Hg(II) with magnetite resulted in the loss of Hg(II) and the formation of volatile elemental Hg (Hg[0]). Kinetic experiments showed that Hg(II) reduction occurred within minutes, with reaction rates increasing with increasing magnetite surface area (0.5 to 2 m2/L) and solution pH (4.8 to 6.7), and decreasing with increasing chloride concentration (10(-6) to 10(-2) mol/L). Mössbauer spectroscopic analysis of reacted magnetite samples revealed a decrease in Fe(II) content, corresponding to the oxidation of Fe(II) to Fe(III) in the magnetite structure. X-ray photoelectron spectroscopy detected the presence of Hg(II) on magnetite surfaces, implying that adsorption is involved in the electron transfer process. These results suggest that Hg(II) reaction with solid-phase Fe(II) is a kinetically favorable pathway for Hg(II) reduction in magnetite-hearing environmental systems.
Overexpression of the <i>Escherichia coli</i> <i>nuo</i>-Operon and Isolation of the Overproduced NADH:Ubiquinone Oxidoreductase (Complex I) (1999)

The proton-pumping NADH:ubiquinone oxidoreductase (complex I) of Escherichia coli is composed of 13 different subunits. The corresponding genes are organized in the nuo-operon (from NADH:ubiquinone oxidoreductase) at min 51 of the E. coli chromosome. To study the structure and function of this complex enzyme, a suitable purification protocol yielding sufficient amount of a stable protein is needed. Here, we report the overproduction of complex I in E. coli and a novel isolation procedure of the complex. Overexpression of the nuo-operon on the chromosome was achieved by replacing its 5'-promotor region with the phage-T7 RNA polymerase promotor and by expressing the genes with the T7 RNA polymerase coded on an inducible plasmid. It is shown by means of enzymatic activity and EPR spectroscopy of cytoplasmic membranes that complex I is overproduced 4-fold after induction. Complex I was isolated by chromatographic steps performed in the presence of dodecyl maltoside. The preparation comprises all subunits and known cofactors and exhibits a high enzymatic activity and inhibitor sensitivity. Due to its stability over a wide pH range and at very high salt concentrations, this preparation is well suited for structural investigations.
Thermal stability of amorphous silicon/silicon nitride stacks for passivating crystalline silicon solar cells (2008)

The thermal stability of amorphous silicon/silicon nitride double layer surface passivation of p-type and n+-type crystalline surfaces is investigated for different deposition temperatures of the silicon nitride capping layer. An increase from 300to400°C results in a significant improvement of the thermal stability of the surface passivation. The minimum surface recombination velocity achieved on p-type (1.5Ωcm) silicon wafers is 0.75±0.6cm∕s and remains at 10±0.5cm∕s after 30min annealing at 500°C.
Porous Boron Nitride Materials: Influence of Structure, Chemistry and Stability on the Adsorption of Organics (2019)

Porous boron nitride (BN) is structurally analogous to activated carbon. This material is gaining increasing attention for its potential in a range of adsorption and chemical separation applications, with a number of recent proof-of-concept studies on the removal of organics from water. Today though, the properties of porous BN – i.e. surface area, pore network, chemistry – that dictate adsorption of specific organics remain vastly unknown. Yet, they will need to be optimized to realise the full potential of the material in the envisioned applications. Here, a selection of porous BN materials with varied pore structures and chemistries were studied for the adsorption of different organic molecules, either directly, through vapour sorption analyses or as part of a water/organic mixture in the liquid phase. These separations are relevant to the industrial and environmental sectors and are envisioned to take advantage of the hydrophobic character of the BN sheets. The materials were tested and regenerated and their physical and chemical features were characterized before and after testing. This study allowed identifying the adsorption mechanisms, assessing the performance of porous BN compared to benchmarks in the field and outlining ways to improve the adsorption performance further.
The fermentation stoichiometry of <i>Thermotoga neapolitana</i> and influence of temperature, oxygen, and pH on hydrogen production (2009)

The hyperthermophilic bacterium, Thermotoga neapolitana, has potential for use in biological hydrogen (H(2)) production. The objectives of this study were to (1) determine the fermentation stoichiometry of Thermotoga neapolitana and examine H(2) production at various growth temperatures, (2) investigate the effect of oxygen (O(2)) on H(2) production, and (3) determine the cause of glucose consumption inhibition. Batch fermentation experiments were conducted at temperatures of 60, 65, 70, 77, and 85 degrees C to determine product yield coefficients and volumetric productivity rates. Yield coefficients did not show significant changes with respect to growth temperature and the rate of H(2) production reached maximum levels in both the 77 degrees C and 85 degrees C experiments. The fermentation stoichiometry for T. neapolitana at 85 degrees C was 3.8 mol H(2), 2 mol CO(2), 1.8 mol acetate, and 0.1 mol lactate produced per mol of glucose consumed. Under microaerobic conditions H(2) production did not increase when compared to anaerobic conditions, which supports other evidence in the literature that T. neapolitana does not produce H(2) through microaerobic metabolism. Glucose consumption was inhibited by a decrease in pH. When pH was adjusted with buffer addition cultures completely consumed available glucose.