gebhart/patrepeval huggingface dataset:
Predicting the risk of pipe failure using gradient boosted decision trees and weighted risk analysis (2022)

Abstract Pipe failure prediction models are essential for informing proactive management decisions. This study aims to establish a reliable prediction model returning the probability of pipe failure using a gradient boosted tree model, and a specific segmentation and grouping of pipes on a 1 km grid that associates localised characteristics. The model is applied to an extensive UK network with approximately 40,000 km of pipeline and a 14-year failure history. The model was evaluated using the Receiver Operator Curve and Area Under the Curve (0.89), briers score (0.007) and Mathews Correlation Coefficient (0.27) for accuracy, indicating acceptable predictions. A weighted risk analysis is used to identify the consequence of a pipe failure and provide a graphical representation of high-risk pipes for decision makers. The weighted risk analysis provided an important step to understanding the consequences of the predicted failure. The model can be used directly in strategic planning, which sets long-term key decisions regarding maintenance and potential replacement of pipes.
Clinical anti‐inflammatory efficacy of arofylline, a new selective phosphodiesterase‐4 inhibitor, in dogs with atopic dermatitis (1999)

Forty atopic dogs were studied for 28 days after the oral administration of four randomised treatments: (A) arofylline (1 mg/kg) twice daily for four weeks; (B) prednisone (0.5 mg/kg) twice daily for the first week, once a day during the second week and every 48 hours for the remaining two weeks; (C) prednisone following the same protocol but at a dose of 0.25 mg/kg; or (D) arofylline (1 mg/kg) twice daily for four weeks plus prednisone (0.25 mg/kg) following the same protocol as in (B) and (C). The degree of pruritus and skin lesions and the side effects were evaluated and graded from 0 to 3 before and weekly during the treatments. In all cases there was a progressive clinical improvement in the clinical signs, with no statistical differences among the four treatments. However, many of the dogs treated with arofylline vomited and had adverse gastrointestinal signs.
Mass spectrometry: A platform for biomarker discovery and validation for Alzheimer's and Parkinson's diseases (2018)

Accurate, reliable, and objective biomarkers for Alzheimer's disease (AD), Parkinson's disease (PD), and related age-associated neurodegenerative disorders are urgently needed to assist in both diagnosis, particularly at early stages, and monitoring of disease progression. Technological advancements in protein detection platforms over the last few decades have resulted in a plethora of reported molecular biomarker candidates for both AD and PD; however, very few of these candidates are developed beyond the discovery phase of the biomarker development pipeline, a reflection of the current bottleneck within the field. In this review, the expanded use of selected reaction monitoring (SRM) targeted mass spectrometry will be discussed in detail as a platform for systematic verification of large panels of protein biomarker candidates prior to costly validation testing. We also advocate for the coupling of discovery-based proteomics with modern targeted MS-based approaches (e.g., SRM) within a single study in future workflows to expedite biomarker development and validation for AD and PD. It is our hope that improving the efficiency within the biomarker development process by use of an SRM pipeline may ultimately hasten the development of biomarkers that both decrease misdiagnosis of AD and PD and ultimately lead to detection at early stages of disease and objective assessment of disease progression. This article is part of the special issue "Proteomics".
Karl Heinrich Rengstorf und Siegfried von Kortzfleisch. Kirche und Synagoge. Handbuch zur Geschichte von Christen und Juden, Darstellung mit Quellen, 1967 (1970)

Kisch Guido. Karl Heinrich Rengstorf und Siegfried von Kortzfleisch. Kirche und Synagoge. Handbuch zur Geschichte von Christen und Juden, Darstellung mit Quellen, 1967. In: Revue des études juives, tome 129, n°1, janvier-mars 1970. pp. 110-112.
S-nitrosoglutathione reductase inhibitors for the prevention and treatment of experimental colitis (2011)

RESULTS: Lgr5 staining in peritumoral areas was localized in the cytoplasm of scattered and isolated epithelial cells in the base of the crypts and luminal epithelium. In AOM-cancers, tumor cells showed staining in focal areas while stromal and pericryptal fibroblasts were intensely positive. Although WT and TSP-1 -/-cancers exhibited no differences in the overall rate of Lgr5 positive cells, higher numbers of positive stromal and pericryptal fibroblasts were detected in TSP-1 -/- tumors when compared to WT tumors (p0.0192). IHC and western blotting confirmed the expression of Lgr5 in cultured fibroblasts isolated from these lesions. CONCLUSIONS: Intense expression of Lgr5 in stromal and pericryptal fibroblasts in chronic colitis and AOM tumors suggests a pivotal role of these cells in the mechanisms mediated by Lgr5. In addition, these findings show that TSP-1 might down regulate the expression of Lgr5 by targeting intestinal fibroblasts. A better understanding of these mechanisms might lead to the use of novel therapies for reducing morbidity in human inflammatory disease and cancer.
Combinatorial engineering to enhance amylosucrase performance: construction, selection, and screening of variant libraries for increased activity (2004)

Amylosucrase is a glucosyltransferase belonging to family 13 of glycoside hydrolases and catalyses the formation of an amylose-type polymer from sucrose. Its potential use as an industrial tool for the synthesis or the modification of polysaccharides, however, is limited by its low catalytic efficiency on sucrose alone, its low stability, and its side reactions resulting in sucrose isomer formation. Therefore, combinatorial engineering of the enzyme through random mutagenesis, gene shuffling, and selective screening (directed evolution) was started, in order to generate more efficient variants of the enzyme. A convenient zero background expression cloning strategy was developed. Mutant gene libraries were generated by error-prone polymerase chain reaction (PCR), using Taq polymerase with unbalanced dNTPs or Mutazyme trade mark, followed by recombination of the PCR products by DNA shuffling. A selection method was developed to allow only the growth of amylosucrase active clones on solid mineral medium containing sucrose as the sole carbon source. Automated protocols were designed to screen amylosucrase activity from mini-cultures using dinitrosalicylic acid staining of reducing sugars and iodine staining of amylose-like polymer. A pilot experiment using the described mutagenesis, selection, and screening methods yielded two variants with significantly increased activity (five-fold under the screening conditions). Sequence analysis of these variants revealed mutations in amino acid residues which would not be considered for rational design of improved amylosucrase variants. A method for the characterisation of amylosucrase action on sucrose, consisting of accurate measurement of glucose and fructose concentrations, was introduced. This allows discrimination between hydrolysis and transglucosylation, enabling a more detailed comparison between wild-type and mutant enzymes.
A 288-GHz Lens-Integrated Balanced Triple-Push Source in a 65-nm CMOS Technology (2013)

A 288-GHz lens-integrated high-power source implemented in a 65-nm CMOS technology is presented. The source consists of two free-running triple-push ring oscillators locked out-of phase by magnetic coupling. The oscillators drive a differential on-chip ring antenna, which illuminates a hyper-hemispherical silicon lens through the backside of the die. An on-wafer breakout of the oscillators core achieves a peak output power of -1.5 dBm with a 275-mW DC power consumption. The radiated power of the packaged source is -4.1 dBm, which is the highest reported radiated power of a single CMOS source beyond 200 GHz. The source die including the antenna occupies only 500 x 570 μ m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> .
The Postural Comfort Zone for Reaching Gestures (2003)

We have proposed a method for objective assessment of postural comfort (Kölsch et al., 2003). We defined comfort as the range of postures that is voluntarily assumed despite the availability of other postures. Designing user interfaces within the limits of comfort zones can avert risks associated with unknown alternative use patters of the interface. Here we report on a user study that investigated the comfort zone for free-hand gestures in the horizontal plane at about stomach height. This space is of particular interest to novel technologies such as gesture recognition and virtual reality. The results are in line with previous studies on postural discomfort, but improve on resolution and are not based on subjective, questionnaire-based data acquisition. This study also serves as an example for how to design studies for comfort evaluation.
The Complete Psychotherapy Treatment Planner (1995)

Organized by 34 major behavioral problems this comprehensive treatment planning guide contains over 1,000 well-crafted, clear statements describing behavioral symptoms, long term goals, short term objectives, and therapeutic interventions. Clinicians can combine these statements to develop individualized treatments for each patient. Ample space is provided so that readers may add their own definitions, goals, objectives, and interventions. Includes a simple treatment plan and a complete appendix of DSM-IV diagnostic codes.
Tomographic reconstruction of time-varying object from linear time-sequential sampled projections (2002)

This paper considers the reconstruction of time-varying object by computer tomography. In practice, projections at different directions are measured in sequence. Thus, when the object is time-varying, the projections at different directions are obtained at different time and will not correspond to those of the same distribution. The reconstructed images will therefore have motion artifacts. A new image reconstruction method based on a priori knowledge of the projections is introduced to solve this problem. A novel iterative algorithm is developed and its validity is demonstrated by computer simulation results.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Component Link Recording and Resource Control for TE Links (2011)

Record Route is a useful administrative tool that has been used
extensively by the service providers. However, when TE links are
bundled, identification of label resource in Record Route Object (RRO)
is not enough for the administrative purpose. Network service
Production and characterization of monoclonal antibodies to the mammalian sperm cytoskeleton (1990)

The cytoskeleton exerts a direct effect on the function of sperm by influencing the distribution of subcellular organelles and plasma membrane molecules. We have prepared six monoclonal antibodies to Triton X-100-insoluble components of the bull sperm cytoskeleton. One of the antibodies reacts with a detachable portion of the bull sperm acrosome. The remainder include an antibody that recognizes the principal and end piece of the tail and another that is specific to the middle piece. Two of the antibodies yield dissimilar staining patterns of the neck region and the tail, and the final monoclonal antibody stains the subacrosomal region and a detachable acrosomal domain of bull sperm. The cross reactivities of the antibodies with hamster sperm and PtK2 cells are described, as is the recognition of bull sperm polypeptides on western blots. The results suggest that these antibodies will provide interesting insights concerning the role of the cytoskeleton in sperm development and function.
Evaluation of Three Insecticides for Control of Pecan Nut Casebearer, 1996 (1998)

Abstract Trials for evaluating the efficacy of insecticides for control of 1st- and 2nd-generation pecan nut casebearer were conducted at a pecan orchard located near Cloutierville, LA. Treatments were applied to 45-year-old pecan trees of mixed cultivars. Confirm 2°F (0.18, 0.25 lb (AI)/acre) and Imidan 70 WSB (1.4 lb (AI)/acre) were evaluated for control of 1 st-generation casebearer. For control of 2nd-generation casebearer (Confirm 2°F (0.25 lb [AI]/acre) was compared with Imidan 70 WSB (1.4 lb (AI)/acre). Plots were laid out in a RCB design with each treatment replicated 4 times (1 tree/replication). Pre-treatment evaluation for the 1 st-generation trial was conducted on 13 May by inspecting 15 tagged nut clusters on each of 4 trees for signs of egg laying (n = 60 nut clusters/treatment)). Pre-treatment evaluation for the 2nd-generation trial was conducted on 2 Jul by inspecting 25 tagged nut clusters on each of 4 trees for signs of egg laying (n = 100 nut clusters/treatment). Treatment applications were made on 16 May (1st generation) and on 3 Jul (2nd generation) using a Meyers, engine-driven air-blast sprayer, calibrated to deliver 167 gpa. Post-treatment evaluations for each trial were conducted by reinspecting the tagged nut clusters for signs of nut entry.
Galectin-8-N-domain Recognition Mechanism for Sialylated and Sulfated Glycans (2011)

Galectin-8 has much higher affinity for 3'-O-sulfated or 3'-O-sialylated glycoconjugates and a Lewis X-containing glycan than for oligosaccharides terminating in Galβ1→3/4GlcNAc, and this specificity is mainly attributed to the N-terminal carbohydrate recognition domain (N-domain, CRD) (Ideo, H., Seko, A., Ishizuka, I., and Yamashita, K. (2003) Glycobiology 13, 713-723). In this study, we elucidated the crystal structures of the human galectin-8-N-domain (-8N) in the absence or presence of 4 ligands. The apo molecule forms a dimer, which is different from the canonical 2-fold symmetric dimer observed for galectin-1 and -2. In a galectin-8N-lactose complex, the lactose-recognizing amino acids are highly conserved among the galectins. However, Arg(45), Gln(47), Arg(59), and the long loop region between the S3 and S4 β-strands are unique to galectin-8N. These amino acids directly or indirectly interact with the sulfate or sialic acid moieties of 3'-sialyl- and 3'-sulfolactose complexed with galectin-8N. Furthermore, in the LNF-III-galectin-8N complex, van der Waals interactions occur between the α1-3-branched fucose and galactose and between galactose and Tyr(141), and these interactions increase the affinity toward galectin-8N. Based on the findings of these x-ray crystallographic analyses, a mutagenesis study using surface plasmon resonance showed that Arg(45), Gln(47), and Arg(59) of galectin-8N are indispensable and coordinately contribute to the strong binding of galectins-8N to sialylated and sulfated oligosaccharides. Arg(59) is the most critical amino acid for binding in the S3-S4 loop region.
Digital image processing techniques for detecting surface alteration - An application on the Alaska Peninsula: A section in <i>The United States Geological Survey in Alaska: Accomplishments during 1983</i> (1985)

In the background are the Bristol Bay Lowlands and Bristol Bay
Organosilica nanotubes: large-scale synthesis and encapsulation of metal nanoparticles (2011)

In this communication we have demonstrated the synthesis of organosilica nanotubes with inner diameter of ∼6 nm and their carbonization to form carbon/silica composite nanotubes. Pd nanoparticles. encapsulated in the organosilica and carbon/silica nanotubes show different catalytic activities in the hydrogenation of cyclohexene.
Synthesis of a novel thiadiazacyclazine (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of a novel thiadiazacyclazineThomas P. SelbyCite this: J. Org. Chem. 1988, 53, 10, 2386–2388Publication Date (Print):May 1, 1988Publication History Published online1 May 2002Published inissue 1 May 1988https://pubs.acs.org/doi/10.1021/jo00245a055https://doi.org/10.1021/jo00245a055research-articleACS PublicationsRequest reuse permissionsArticle Views74Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Imaging performance of the liquid-crystal-adaptive lens with conductive ladder meshing (1997)

The liquid-crystal-adaptive lens (LCAL) is an electro-optical device that utilizes a graded index of refraction to bring light to focus. A set of electrodes controls the index variation in a liquid-crystal thin film. One can vary the focal length of the LCAL by changing the voltages applied to the device. The discrete nature of the electrodes causes phase aberrations. We introduce a novel electrode architecture, called conductive ladder meshing (CLM), that we developed to greatly reduce the static phase aberration (caused by the electrode structure). To reduce the dynamic phase aberration (associated with inaccurate voltages), we used a simulated-annealing voltage-dithering technique. The coherent transfer function of the LCAL was derived so that the performance of the CLM LCAL could be predicted theoretically. Theoretical analysis indicates that the CLM LCAL scatters less than 30% of incident light compared with scattering of 65% in the previous version. The focal-spot performance of the spherical LCAL was measured under coherent illumination for plane-wave illumination. Because of the improved quality of the spherical LCAL, true imaging experiments are demonstrated for a single incoming polarization under white-light illumination. Images formed by the spherical LCAL are comparable with those formed by a fixed lens in terms of resolution, although the contrast is worse.
An effective link error prediction technique for MIMO-OFDM systems with ML receiver (2012)

In this paper, we propose an accurate link performance abstraction technique for multiple-input multiple-output (MIMO) orthogonal frequency-division multiplexing systems with maximum likelihood (ML) receiver. The performance of ML detection (MLD) is estimated by using capacity bounds of two simple linear receivers. To this end, we give a simple parametrization to compute the desired per-stream signal-to-noise ratio (SNR) values, which can be applied for both vertically and horizontally coded MIMO systems. Based on the per-stream SNR estimates, the block error rate performance for each encoding block is finally obtained using the received-bit information rate metrics. From extensive simulations, we verify that the proposed method is accurate in the MIMO-MLD link evaluation with very low computational complexity.
Phosphinic Derivatives as New Dual Enkephalin-Degrading Enzyme Inhibitors: Synthesis, Biological Properties, and Antinociceptive Activities (2000)

The development of dual inhibitors of the two zinc metallopeptidases, neprilysin (neutral endopeptidase) and aminopeptidase N involved in the inactivation of the opioid peptides, enkephalins, represents an attractive physiological approach in the search for new analgesics devoid of the major drawbacks of morphine. Phosphinic compounds, corresponding to the general formula H(3)N(+)-CH(R(1))-P(O)(OH)-CH(2)-CH(R(2))-CONH-CH(R(3))-COO(-), able to act as transition-state analogues and to fit the S(1), S(1)', and S(2)' subsites of both enzymes were designed. Selection of the R(1), R(2), and R(3) residues for optimal recognition of these enzymes led to the first dual competitive inhibitors with K(i) values in the nanomolar range for neprilysin and aminopeptidase N. These compounds induce potent analgesic responses after intracerebroventricular or intravenous administrations in mice (hot plate test), and several of them were shown to be, at least, 10 times more potent than the previously described dual inhibitors.
Fluxless Bonding of Large Silicon Chips to Ceramic Packages Using Electroplated Eutectic Au/Sn/Au Structures (2009)

A fluxless process of bonding large silicon chips to ceramic packages has been developed using a Au-Sn eutectic solder. The solder was initially electroplated in the form of a Au/Sn/Au multilayer structure on a ceramic package and reflowed at 430°C for 10 min to achieve a uniform eutectic 80Au-20Sn composition. A 9 mm × 9 mm silicon chip deposited with Cr/Au dual layers was then bonded to the ceramic package at 320°C for 3 min. The reflow and bonding processes were performed in a 50-mTorr vacuum to suppress oxidation. Therefore, no flux was used. Even without any flux, high-quality joints were produced. Microstructure and composition of the joints were studied using scanning electron microscopy with energy-dispersive x-ray spectro- scopy. Scanning acoustic microscopy was used to verify the joint quality over the entire bonding area. To employ the x-ray diffraction method, samples were made by reflowing the Au/Sn/Au structure plated on a package. This was followed by a bonding process, without a Si chip, so that x-rays could scan the solder surface. Joints exhibited a typical eutectic structure and consisted of (Au,Ni)Sn and (Au,Ni)5Sn phases. This novel fluxless bonding method can be applied to packaging of a variety of devices on ceramic packages. Its fluxless nature is particularly valuable for packaging devices that cannot be exposed to flux such as sensors, optical devices, medical devices, and laser diodes.
The Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene may influence morphine requirements in cancer pain patients (2005)

Catechol-O-methyltransferase (COMT) inactivates dopamine, epinephrine and norepinephrine in the nervous system. A common functional polymorphism (Val158Met) leads to a three- to-four-fold variation in the COMT enzyme activity, the Met form displaying lower enzymatic activity. The Val158Met polymorphism affects pain perception, and subjects with the Met/Met genotype have the most pronounced response to experimental pain. Based on this information we analyzed the influence from the COMT Val158Met polymorphism on the efficacy of morphine in a cohort of patients suffering from cancer pain. We genotyped 207 Caucasian cancer patients on morphine treatment with respect to the Val158Met polymorphism and compared the morphine doses, serum concentrations of morphine and morphine metabolites between the genotype groups. Patients with the Val/Val genotype (n=44) needed more morphine (155+/-160 mg/24 h) when compared to the Val/Met (117+/-100 mg/24 h; n=96) and the Met/Met genotype (95+/-99 mg/24 h; n=67) groups (P=0.025). This difference was not explained by other factors such as duration of morphine treatment, performance status, time since diagnosis, perceived pain intensity, adverse symptoms, or time until death. These results suggest that genetic variation in the COMT gene may contribute to variability in the efficacy of morphine in cancer pain treatment.