gebhart/patrepeval huggingface dataset:
Banked EBV-specific T-cells from HLA-partially matched normal donors to induce durable remissions of rituximab refractory EBV<sup>+ </sup>B-cell lymphomas post hematopoietic and organ allografts. (2015)

10016 Background: EBV+ B-cell lymphomas (EBV+ BCL) are life threatening after allogeneic hematopoietic (HCT) or organ (SOT) transplant. In Phase II trials, we are testing the safety and activity of GMP grade EBV-specific cytotoxic T-cells (EBVCTL) generated from over 300 consenting normal seropositive donors, characterized as to EBV-specificity, HLA type and HLA restriction and cryopreserved in a bank for adoptive therapy. Methods: We have treated 13 SOT and 34 HCT recipients with pathologically documented EBV+BCL. All patients (pts) had failed to respond or relapsed following rituximab treatment; 11 SOT recipients also failed 1-5 courses of rituximab with chemotherapy. Pts received 1-6 courses of T-cell infusions, each separated by 3 wks observation. A course consisted of 3 weekly intravenous doses of EBVCTL, each dose providing 1- 2x106 EBVCTL/kg. EBVCTLs were selected based on matching for at least 2 HLA alleles (HLA, A, B, C or DR) and restriction by an HLA allele shared by the pt or the pt’s disease. Results: EBVCTL infusions were well tolerated. 1 pt had transient fever after one dose in a 2o course. One HCT pt developed grade 1 skin GVHD that cleared with topical steroid. No HCT or SOT pt had cell count depressions, a rejection reaction, or cytokine release syndrome. Of 34 HCT pts, 19 have durable CRs, 3 sustained PRs (>5mo, >16mo; >15mo); 2 had SD and10 disease progression (PD) CR+PR=65%. Of 13 SOT pts, 1 has a durable CR (>22mo) and 7 durable PRs (>6mo; >16mo; 17mo; >10mo; >24mo; >42mo; >114mo) (CR+PR=62%). Responses were achieved after 1-6 courses (median 2). EBV-specific CTLp rose in the blood of responding pts after each EBVCTL course, but not in pts with PD. After 1 cycle, 7 pts with PD received EBVCTL from a second donor restricted by a different HLA allele shared by the pt, of whom, 5 achieved a CR or durable PR. No pt with CR or PR has had progression requiring alternative therapy. Conclusions: Thus, adoptive transfer of HLA partially matched EBVCTL from our cryopreserved bank, that are restricted by HLA alleles expressed by the pt’s disease, has minimal toxicity and induces durable regression of EBV+BCL refractory to rituximab and/or chemotherapy in a high proportion of HCT and SOT recipients. Clinical trial information: NCT01498484.
Isolation and characterization of a biosurfactant producing strain, Brevibacilis brevis HOB1 (2008)

Biosurfactant-producing bacteria were isolated from the production water of an oil field. Isolates were screened for biosurfactant production using surface tension test. The highest reduction of surface tension was achieved with a bacterial strain which was identified by 16S rRNA gene sequencing as Brevibacilis brevis HOB1. It has been investigated using different carbon and nitrogen sources. It showed that the strain was able to grow and reduce the surface tension of the broth to 29 mN/m on commercial sugar and maltose, and to 32 mN/m on glucose after 72 h of growth. The maximum amount of biosurfactant was obtained when nitrate ions were supplied as nitrogen source. Biosurfactant produced by Brevibacilis brevis HOB1 was confirmed as a lipopeptide class of biosurfactant using TLC test and mass spectra. Lipopeptide isoforms were isolated from cell-free supernatants by acid-precipitation followed by one step of chromatographic separation on solid-phase ODS C18 column. The separation was confirmed by HPLC and ESI Q-TOF MS spectroscopy. Comparing the mass data obtained and the mass numbers reported for the lipopeptide complexes from other strains, it can be concluded that the major lipopeptide product of Brevibacilis brevis HOB1 is the surfactin isoform. This lipopeptide showed strong antibacterial and antifungal activity. It is a candidate for the biocontrol of pathogens in agriculture and other industries.
Production of an inactivated rabies vaccine in primary dog kidney cells. (1978)

In this paper the large-scale production of a purified inactivated rabies vaccine in primary dog kidney cells cultivated in microcarrier culture is described. The potency in the NIH-test and the antigenicity of this vaccine in other animal experiments were comparable with the antigenicity of vaccine prepared in human diploid cells. The antibody response was greatly enhanced by the addition of AIPO4 as adjuvant. The results of an initial clinical trial are presented.
Protecting Deaf Suspects' Right to Understand Criminal Proceedings (1984)

DEAF SUSPECTS' RIGHTunderstand the proceedings at all stages of the criminal process. 4 The deaP number about two million in America, 6 or about one person in every 110. 7 About thirteen million Americans are hearingimpaired, 8 suffering from some form of significant hearing loss.Many hearing-impaired people function well in society with effective use of graphic regions, ages, educational levels, and socio-economic backgrounds of the deaf.Also, A.S.L. is American only; the deaf in other nations use different sign languages.4 For a short discussion of recent developments in the criminal justice system's protection of the rights of deaf suspects, see Goldberg, Gardner & DuBow, Rights of the Deaf.Ensuring
Principles of digital and analog communications (1989)

This textbook for the first course in communications covers analog and digital systems and emphasizes digital communications. It covers data transmission, signal space, optimal receivers, and pulse code modulation, and includes readable treatments of coded modulation and continuous phase modulation. Advanced mathematics is kept to a minimum-Fourier series, Fourier transforms, linear systems, random variables, and stochastic process are described thoroughly. It includes data compression of speech and images and a full chapter coverage of information theory, rate distortion theory and coded modulation. It relates digital communications theory to current practice and covers digital communications over band-width constrained channels, including pulse shaping and equilization. -- Dieser Text bezieht sich auf eine vergriffene oder nicht verfügbare Ausgabe dieses Titels.
On the Limits of Software Watermarking (1998)

Watermarking embeds a secret message into a cover message. In media watermarking the secret is usually a copyright notice and the cover a digital image. Watermarking an object discourages intellectual property theft, or when such theft has occurred, allows us to prove ownership. The Software Watermarking problem can be described as follows. Embed a structure W into a program P such that: W can be reliably located and extracted from P even after P has been subjected to semantics preserving transformations such as code optimization and obfuscation; W is stealthy; W has a high data rate; embedding W into P does not adversely affect the performance of P; and W has a mathematical property that allows us to argue that its presence in P is the result of deliberate actions. In the first part of the paper we construct an informal taxonomy of software watermarking techniques. In the second part we formalize these results. Finally, we propose a new software watermarking technique in which a dynam...
GaInAsP/InP integrated ridge laser with a butt-jointed transparent optical waveguide fabricated by single-step metalorganic vapor-phase epitaxy (1990)

A monolithic integration between an active and an external passive waveguide in such a way they are directly butt-jointed in a single epitaxial step is demonstrated in the InP system. The growth behavior during nonplanar metalorganic vapor-phase epitaxy on a patterned InP substrate was investigated by using a periodic structure on GaInAs or InGaAsP/InP layers. A 1.5-mm-long ridge laser consisting of an active guide butt-jointed to a transparent waveguide has exhibited lasing oscillation at 1.5 μm with a threshold current of 82 mA. A coupling coefficient of 60% has been experimentally measured.
Reduction Mechanism of Threading Dislocation Density in GaAs Epilayer Grown on Si Substrate by High-Temperature Annealing (1994)

The effects of high-temperature annealing were investigated by transmission electron microscopy (TEM) and secondary ions mass spectroscopy (SIMS) on reduction of threading dislocation density in GaAs epilayers grown on Si substrates. It was found that the dislocation density in the annealed GaAs epilayers grown on Si was remarkably reduced. This phenomenon could be attributed to an increase in the velocity of dislocation glide motion including climb motion caused by reaction with vacancies at high temperature. In addition, specific long dislocations running parallel to the GaAs–Si hetero-interface were observed. The specific dislocations were distributed around the diffusion front of Si atoms in the GaAs epilayer. These results led to a model for reduction of threading dislocation density by high-temperature annealing.
Pancreas and beta-cell development: from the actual to the possible (2006)

The development of insulin-producing pancreatic beta (beta)-cells represents the culmination of a complex developmental program. Cells of the posterior foregut assume a pancreatic identity, cells within the expanding pancreatic primordia adopt an endocrine fate, and a subset of these precursors becomes competent to generate beta-cells. Postnatally, beta-cells are primarily maintained by self-duplication rather than new differentiation. Although major gaps in our knowledge still persist, experiments across several organisms have shed increasing light on the steps of beta-cell specification and differentiation. Increasing our understanding of the extrinsic, as well as intrinsic, mechanisms that control these processes should facilitate efforts to regenerate this important cell type in humans.
Alienation, Hedonism, and Life-Vision of Delinquents (1967)

The authors had hypothesized that delinquents as compared to non-delinquents are higher in alienation, more impulsively hedonistic, and poorer in vision of goals.Delinquent youths, 16 to 18 years old, from different correctional institutions in Florida were administered questionnaires and compared with high school boys.The hypothesis was confirmed.The intra-group comparison further revealed that the more experienced delinquents possessed better vision of their life goals.The institutionalized delinquents are more mother-centered; the non-delinquents are more father centered.The delinquents' weak affectional ties are related with alienation and non-delinquents' identification with their father is associated with better vision of life goals.
Thermal expansion data for eight optical materials from 60 K to 300 K (1977)

Coefficients of linear thermal expansion are reported, in the range 60 K to room temperature, for eight optical materials: Polytran potassium chloride and Polytran calcium fluoride-Harshaw; chemical-vapor-deposited (CVD) zinc sulfide and zinc selenide-Raytheon; germanium (single-crystal and polycrystal); crystalline magnesium fluoride, potassium dihydrogen phosphate (KDP), and lithium niobate-Harshaw. The last three are anisotropic crystals; thermal expansion was measured both parallel and perpendicular to the c axis.
Multipoint phase calibration for improved compensation of inherent wavefront distortion in parallel aligned liquid crystal on silicon displays (2007)

The inherent distortion of a reflective parallel aligned spatial light modulator (SLM) may need compensation not only for the backplane curvature but also for other possible nonuniformities caused by thickness variations of the liquid crystal layer across the aperture. First, we build a global look-up table (LUT) of phase modulation versus the addressed gray level for the whole device aperture. Second, when a lack of spatial uniformity is observed, we define a grid of cells onto the SLM aperture and develop a multipoint calibration. The relative phase variations between neighboring cells for a uniform gray level lead us to build a multi-LUT for improved compensation. Multipoint calibration can be done using either phase-shift interferometry or Fourier diffraction pattern analysis of binary phase gratings. Experimental results show the compensation progress in diffractive optical elements displayed on two SLMs.
Primeras experiencias docentes. Un estudio de caso en la asignatura de «Nuevas Tecnologías aplicadas a la Educación» (2008)

En numerosas ocasiones no prestamos la atencion que merece al proceso que una persona experimenta al iniciarse en el complejo mundo de la docencia. Cada etapa educativa tiene unas caracteristicas bien definidas que condicionaran el trabajo y la adaptacion del docente novel, en un proceso que no siempre es facil. El presente articulo analiza la incorporacion a la ensenanza de un profesor novel en la asignatura de Nuevas Tecnologias Aplicadas a la Educacion (NNTT), en la Facultad de Educacion y Trabajo Social de la Universidad de Valladolid (UVa). Para ello, hemos puesto en practica un proceso de investigacion interpretativo, siguiendo los principios del analisis cualitativo con estudio de casos (Stake, 1998) durante el curso academico 2007-2008. Las distintas peculiaridades teorico-practicas del diseno de la asignatura se asientan en los principios establecidos dentro del campo del Computer Supported Collaborative Learning (CSCL) (Koschman, 1996) como mediador de procesos de ensenanza-aprendizaje, que a su vez, se apoyan en una metodologia participativa basada en el Inquiry based Learning (IBL) (Bruce, 2000). Ante este diseno innovador, compartido a su vez por otros tres docentes en el seno de una comunidad de practica educativa, hemos analizado el proceso de formacion tecnologico-educativo llevado a cabo por este docente. A su vez, el analisis de esta experiencia nos ha ayudado a profundizar en la comprension del tipo de competencias que los docentes noveles necesitan en disenos educativos como este, en el proceso de convergencia propuesto por el Espacio Europeo de Educacion Superior (EEES).
The Molecular Design of Prodrugs by Functional Group (2010)

This chapter contains sections titled: Introduction The Prodrug Concept and Basics of Design Common Functional Group Approaches in Prodrug Design Conclusions References
A single average crossed acoustic response (1976)

Although the Crossed Acoustic Response is the simplest objective test of hearing acuity, as it can be used without an anaesthetic in the mobile child, a serious obstacle to its wide use has been cost. This was because two averagers have been necessary. This paper describes a modification of the equipment which is not only cheap but which can be used to adapt any existing electrocochleograph or cortical evoked response recorder.
A new approach to harmonic compensation in power systems (2003)

A novel approach to compensate for harmonics in power systems is proposed. The approach differs from conventional passive and active filters in its compensation principle. A practical system configuration to implement the approach is presented. It consists of a small-VA-rating PWM (pulsewidth-modulated) converter and a passive filter. The compensation principle is described, and compensation characteristics are examined theoretically and experimentally. The practicability and validity of the approach are experimentally demonstrated.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Reaction Mechanism of Monoacyl- and Bisacylphosphine Oxide Photoinitiators Studied by <sup>31</sup>P-, <sup>13</sup>C-, and <sup>1</sup>H-CIDNP and ESR (1996)

31P-NMR-CIDNP (CIDNP = chemically induced dynamic nuclear polarization) spectroscopy was applied for the first time to investigate the formation and reaction of phosphorus-centered radicals obtained from phosphorus-containing photoinitiators. 13C-NMR- and 1H-NMR-CIDNP and ESR spectroscopies were used as complementary experimental techniques for the elucidation of the photochemistry of these compounds. The large hyperfine coupling constants of the 31P-nucleus results in a violation of Kaptein's rules, which is the only observation of this kind in 13C-NMR-CIDNP spectra reported so far. Interpretation of the CIDNP spectra, using a modification of Kaptein's rules for the 13C-NMR- and 1H-NMR-CIDNP, consistently shows that all compounds investigated undergo a photoinduced cleavage of the carbonyl−phosphinoyl bond from a triplet state. The fate of the primary radicals is discussed, and it is unambiguously shown by trapping experiments that the novel bisacylphosphine oxide photoinitiators give four radicals in a stepwise process.
New approaches for the production of nano‐, micro‐, and polycrystalline silicon thin films (2004)

We review current models and propose new approaches for the production of silicon thin films by low temperature plasma processes. Growth models have often been borrowed from those developed for hydrogenated amorphous silicon and are based on surface diffusion of SiH3. However, in situ growth studies have also pointed out the fast diffusion of hydrogen and its role in the crystallization of the film through subsurface reactions. Moreover, ions and silicon nanocrystals can also play a crucial role in microcrystalline silicon deposition. We show that ion bombardment is responsible for the formation of a disorderd subsurface layer while deposition on a cooled substrate allows us to trap the silicon nanocrystals and to prevent their growth, thus leading to nanocrystalline thin films. The deposition at 200 °C on substrates with a low density of surface defects allows for the surface mobility of the nanocrystals and their agglomeration to form large grains, thus resulting in polycrystalline silicon thin films. (© 2004 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)
Pravastatin chitosan nanogels-loaded erythrocytes as a new delivery strategy for targeting liver cancer (2015)

Chitosan nanogels (CNG) are developed as one of the most promising carriers for cancer targeting. However, these carriers are rapidly eliminated from circulation by reticuloendothelial system (RES), which limits their application. Therefore, erythrocytes (ER) loaded CNG as multifunctional carrier may overcome the massive elimination of nanocarriers by RES. In this study, erythrocytes loaded pravastatin-chitosan nanogels (PR-CNG-ER) were utilized as a novel drug carrier to target liver cancer. Thus, PR-CNG formula was developed in nanosize, with good entrapment efficiency, drug loading and sustained release over 48 h. Then, PR-CNG loaded into ER were prepared by hypotonic preswelling technique. The resulting PR-CNG-ER showed 36.85% of entrapment efficiency, 66.82% of cell recovery and release consistent to that of hemoglobin over 48 h. Moreover, PR-CNG-ER exhibited negative zeta potential, increasing of hemolysis percent, marked phosphatidylserine exposure and stomatocytes shape compared to control unloaded erythrocytes. PR-CNG-ER reduced cells viability of HepG2 cells line by 28% compared to unloaded erythrocytes (UER). These results concluded that PR-CNG-ER are promising drug carriers to target liver cancer.
Palladium-Decorated Hydrogen-Gas Sensors Using Periodically Aligned Graphene Nanoribbons (2014)

Polymer residue-free graphene nanoribbons (GNRs) of 200 nm width at 1 μm pitch were periodically generated in an area of 1 cm(2) via laser interference lithography using a chromium interlayer prior to photoresist coating. High-quality GNRs were evidenced by atomic force microscopy, micro-Raman spectroscopy, and X-ray photoelectron spectroscopy measurements. Palladium nanoparticles were then deposited on the GNRs as catalysts for sensing hydrogen gases, and the GNR array was utilized as an electrically conductive path with less electrical noise. The palladium-decorated GNR array exhibited a rectangular sensing curve with unprecedented rapid response and recovery properties: 90% response within 60 s at 1000 ppm and 80% recovery within 90 s in nitrogen ambient. In addition, reliable and repeatable sensing behaviors were revealed when the array was exposed to various gas concentrations even at 30 ppm.
RNAi-mediated silencing of hepatic<i>Alas1</i>effectively prevents and treats the induced acute attacks in acute intermittent porphyria mice (2014)

The acute hepatic porphyrias are inherited disorders of heme biosynthesis characterized by life-threatening acute neurovisceral attacks. Factors that induce the expression of hepatic 5-aminolevulinic acid synthase 1 (ALAS1) result in the accumulation of the neurotoxic porphyrin precursors 5-aminolevulinic acid (ALA) and porphobilinogen (PBG), which recent studies indicate are primarily responsible for the acute attacks. Current treatment of these attacks involves i.v. administration of hemin, but a faster-acting, more effective, and safer therapy is needed. Here, we describe preclinical studies of liver-directed small interfering RNAs (siRNAs) targeting Alas1 (Alas1-siRNAs) in a mouse model of acute intermittent porphyria, the most common acute hepatic porphyria. A single i.v. dose of Alas1-siRNA prevented the phenobarbital-induced biochemical acute attacks for approximately 2 wk. Injection of Alas1-siRNA during an induced acute attack significantly decreased plasma ALA and PBG levels within 8 h, more rapidly and effectively than a single hemin infusion. Alas1-siRNA was well tolerated and a therapeutic dose did not cause hepatic heme deficiency. These studies provide proof-of-concept for the clinical development of RNA interference therapy for the prevention and treatment of the acute attacks of the acute hepatic porphyrias.
Cardiac Autonomic Regulation During Sleep in Idiopathic REM Sleep Behavior Disorder (2007)

REM-related cardiac and respiratory responses are absent in subjects with idiopathic RBD.
Comparative antitumor properties in rodents of irreversible inhibitors of L-ornithine decarboxylase, used as such or as prodrugs. (1989)

The antitumor properties of (E)-2-(fluoromethyl)dehydroornithine methyl ester (delta-MFMO-ME) and of (E)-2-(fluoromethyl)dehydroornithine ethyl ester (delta-MFMO-EE), the prodrugs of delta-MFMO, an irreversible inhibitor of mammalian L-ornithine decarboxylase (ODC) 14 times more potent than alpha-difluoromethylornithine (DFMO) and equipotent to (2R,5R)-6-heptyne-2,5-diamine (MAP) in vitro, have been investigated in L1210 leukemia- and Lewis lung carcinoma-bearing mice. The anticancer properties of these esters have been compared with those of DFMO and MAP as a function of the dose, the route of administration, and the stage of the lewis lung carcinoma development in mice. The two esters, administered i.p. shortly after cell inoculation at one-fifth the dose of DFMO, prolonged the survival of mice-bearing leukemia to the same extent as DFMO and MAP. When administered orally to leukemia-bearing mice the two esters were equipotent at prolonging survival. The methyl ester appears, however, to be slightly, but not significantly, more effective than the ethyl ester against leukemia when given i.p., maximum prolongation of the mice survival (79%) occurring at 0.5 g/kg methyl ester every 12 h. The two esters achieve at one-sixth to one-twelfth the dose, antitumor effects similar to DFMO in the Lewis lung carcinoma model, the ethyl ester being slightly, but not significantly, more effective than the methyl ester when administered orally. Moreover, the ethyl ester causes greater reduction of tumor growth than DFMO (P less than 0.05) and MAP (P less than 0.01) in this model. Inhibition of tumor growth is correlated with spermidine depletion and an increase of decarboxylated-S-adenosylmethionine, the aminopropyl donor in the spermidine and spermine synthase reactions. All ODC inhibitors, however, lose most of their antitumor properties when administered at late stage of Lewis lung carcinoma development. Finally, this study demonstrates the advantage of using prodrugs of delta-MFMO, an inhibitor of ODC, since they possess longer duration of action, higher potency, and in some cases better antitumor efficiency than the parent direct inhibitor of ODC. Moreover, and as already noticed for DFMO or MAP, no sign of overt toxicity is caused by the highest effective antitumor doses of the esters.