gebhart/patrepeval huggingface dataset:
Development of Noxa-like BH3 Mimetics for Apoptosis-Based Therapeutic Strategy in Chronic Lymphocytic Leukemia (2012)

Abstract Despite real advances made in chemoimmunotherapy, chronic lymphocytic leukemia (CLL) is still an incurable disease. New therapeutic strategies based on the restoration of the cell death program seemed relevant. Some members of the Bcl-2 family are critical players in the defective apoptotic program in CLL cells and/or targets of apoptosis inducers in vitro. The concept of BH3 mimetics has led to the characterization of small molecules mimicking proapoptotic BH3-only members of the Bcl-2 family by their ability to bind and antagonize the prosurvival members. Some putative or actual BH3 mimetics are already being tested in clinical trials with somewhat promising results. However, none of them has a high enough interaction affinity with Mcl-1, a crucial antiapoptotic factor in CLL. It has been suggested that resistance to BH3 mimetics can be overcome by using inhibitors of Mcl-1 expression. An alternative and more direct strategy is to design mimetics of the Noxa BH3 domain, which is a specific antagonistic Mcl-1 ligand. The development of such Noxa-like BH3 mimetics, capable of directly interacting with Mcl-1 and efficiently neutralizing its antiapoptotic activity, is extremely important to evaluate their impact on the clinical outcome of patients with CLL. Mol Cancer Res; 10(6); 673–6. ©2012 AACR.
Highly Efficient Multiphoton-Absorption-Induced Luminescence from Gold Nanoparticles (2005)

We demonstrate that highly efficient photoluminescence is generated from gold nanoparticles as small as a few nanometers in diameter upon irradiation with sub-100-fs pulses of 790-nm light. Strong emission is observed at excitation intensities comparable to or less than those typically used for multiphoton imaging of fluorescently labeled biological samples. The particles have polarized emission, can radiate more efficiently than single molecules, do not exhibit significant blinking, and are photostable under hours of continuous excitation. These observations suggest that metal nanoparticles are a viable alternative to fluorophores or semiconductor nanoparticles for biological labeling and imaging.
A wireless guided wave excitation technique based on laser and optoelectronics (2010)

There are on-going efforts to utilize guided waves for structural damage detection. Active sensing devices such as lead zirconate titanate (PZT) have been widely used for guided wave generation and sensing. In addition, there has been increasing interest in adopting wireless sensing to structural health monitoring (SHM) applications. One of major challenges in wireless SHM is to secure power necessary to operate the wireless sensors. However, because active sensing devices demand relatively high electric power compared to conventional passive sensors such as accelerometers and strain gauges, existing battery technologies may not be suitable for long-term operation of the active sensing devices. To tackle this problem, a new wireless power transmission paradigm has been developed in this study. The proposed technique wirelessly transmits power necessary for PZT-based guided wave generation using laser and optoelectronic devices. First, a desired waveform is generated and the intensity of the laser source is modulated accordingly using an electro-optic modulator (EOM). Next, the modulated laser is wirelessly transmitted to a photodiode connected to a PZT. Then, the photodiode converts the transmitted light into an electric signal and excites the PZT to generate guided waves on the structure where the PZT is attached to. Finally, the corresponding response from the sensing PZT is measured. The feasibility of the proposed method for wireless guided wave generation has been experimentally demonstrated.
ON THE FINITE HILBERT TRANSFORMATION (1951)

Journal Article ON THE FINITE HILBERT TRANSFORMATION Get access F.G. TRICOMI F.G. TRICOMI Pasadena Search for other works by this author on: Oxford Academic Google Scholar The Quarterly Journal of Mathematics, Volume 2, Issue 1, 1951, Pages 199–211, https://doi.org/10.1093/qmath/2.1.199 Published: 01 January 1951 Article history Received: 24 March 1950 Published: 01 January 1951
Microbial Reverse Electrodialysis Cells for Synergistically Enhanced Power Production (2011)

A new type of bioelectrochemical system for producing electrical power, called a microbial reverse-electrodialysis cell (MRC), was developed to increase voltages and power densities compared to those generated individually by microbial fuel cells (MFCs) or reverse electrodialysis (RED) systems. In RED systems, electrode overpotentials create significant energy losses due to thermodynamically unfavorable electrode reactions, and therefore a large number of stacked cells must be used to have significant energy recovery. This results in high capital costs for the large number of membranes, and increases energy losses from pumping water through a large number of cells. In an MRC, high overpotentials are avoided through oxidation of organic matter by exoelectrogenic bacteria on the anode and oxygen reduction on the cathode. An MRC containing only five pairs of RED cells, fed solutions typical of seawater (600 mM NaCl) and river water (12 mM NaCl) at 0.85 mL/min, produced up to 3.6 W/m(2) (cathode surface area) and 1.2-1.3 V with acetate as a substrate. Pumping accounted for <2% of the produced power. A higher flow rate (1.55 mL/min) increased power densities up to 4.3 W/m(2). COD removal was 98% with a Coulombic efficiency of 64%. Power production by the individual components was substantially lower with 0.7 W/m(2) without salinity driven energy, and <0.015 W/m(2) with reduced exoelectrogenic activity due to substrate depletion. These results show that the combination of an MFC and a RED stack synergistically increases performance relative to the individual systems, producing a new type of system that can be used to more efficiently capture salinity driven energy from seawater and river water.
A European Feather Moss,<i>Pseudoscleropodium purum,</i>Naturalized Widely in New York State in Cemeteries (2001)

Plants of Pseudoscleropodium purum, a moss native to central and western Europe, are well established in western, central, and eastern New York State, mainly in lawns of cemeteries, especially those with moist clayey soil, shade provided by conifers (Picea abies, Thuja occidentalis) in small groves, and periodic mowing. Male and female plants occur in Rensselaer County, New York cemeteries, but not in the same ones. Sporophytes have not been found, and reproduction appears to occur vegetatively as plants are cut and spread during lawn maintenance. If spore production is established within the naturalized range of this moss in the northeastern United States, the species may become more widespread, and possibly invasive. While the date and method of introduction into the State of New York are unknown, a 19th century specimen of P. purum from the West Coast of North America indicates that the moss may have reached that region as packing material in the late-1800's.
Enhancement of camera-based whiteboard images (2009)

Quality of camera-based whiteboard images is highly related to the light environment and the writing effect of the content. Specular reflection and low contrast reduce the readability of captured whiteboard images frequently. A novel method is proposed to enhance camera-based whiteboard images in this paper. The images are enhanced by removing the highlight specular reflection to improve the visibility and emphasizing the content to improve the readability of the whiteboards. The method can be practically embedded in mobile devices with image capturing cameras.
Conversion of <scp>L</scp>‐Cysteine into <scp>D</scp>‐α‐Amino Acids and Related Transformations (2011)

In Figure The correct version of Figure 1 is shown below. The Authors Figure 1. Compound structures for Table Compounds with numbers are described in the Exp. Section (with the exception of side products 37, 38, and 42).
Suppression of Higher-Order Lateral Modes in Broad-Area Diode Lasers by Resonant Anti-Guiding (2013)

For a maximum fiber-coupled power, high power broad-area diode lasers must operate with a small lateral far-field divergence at high continuous wave (CW) powers. However, these structures are laterally multi-moded, with a low beam quality and wide emission angles. We present a new approach to suppress higher-order lateral modes based on an anti-guiding layer with a high refractive index inserted at the edges of the active stripe. Simulations of planar waveguides containing germanium layers reveal that strong mode-coupling effects occur. These are found to vary as a function of the thickness of the inserted layer. By embedding the germanium layer in the outer region of a ridge-waveguide, the mode coupling effects result in a reduction of the modal gain of higher-order lateral modes. The lateral far-field divergence of fabricated 90- μm stripe lasers emitting at 980 nm and containing such an anti-guiding layer is narrowed by 3 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">°</sup> at a CW output power of 10 W.
Image Compositing System using Omni-Directional Illumination (2005)

The composite images in virtual studios as used by broadcast stations require that unnatural sensations be minimized real time characteristics be maintained. If the lighting conditions of captured images do not match those of computer graphics (CG), however, the composite image will appear unnatural to viewers . In response to this problem, we used projectors to reproduce the CG lighting environment in real space with the aim of reducing this unnatural feeling caused by unmatched lighting conditions. At the same time, chroma keying, the conventional video composite technique , does not allow for the setting of any lighting conditions on the real space side, thereby preventing the proposed light big reproduction technique from being applied to a virtual studio. For this reason, we developed a new video composite technique . The technique that uses transmission retro reflective material, an infrared camera placed at a conjugate position with respect to a color camera, and infrared lighting to remove the constraint conditions associated with the chroma key technique. In this paper, we formally propose this new technique and demonstrate its effectiveness.
CONCEPÇÕES SOBRE EVOLUÇÃO BIOLÓGICA ENTRE UNIVERSITÁRIOS CRISTÃOS: CIÊNCIA E RELIGIÃO EM CONFLITO? (2013)

<p class="URIsumresabsartigo"><strong>Resumo: </strong>A teoria da Evolução Biológica, considerada o eixo central e integrador na organização dos conteúdos do ensino de Biologia, possui dificuldades de ordem conceitual e metodológica que configuram uma série de desafios para seu ensino. No presente trabalho, buscou-se identificar e caracterizar os elementos constituintes do conceito de Evolução Biológica entre estudantes universitários cristãos. A coleta de dados foi realizada com estudantes de diversos cursos de graduação da Universidade Federal de Santa Catarina, participantes da Missão Universitária Luterana. Foram constatados, entre outros aspectos: concepções de Evolução Biológica contendo elementos que remetem a noções de progresso ou melhoramento das espécies; concepções sobre origem da vida na Terra e origem da espécie humana como fenômenos que teriam ocorrido diferentemente das outras espécies. Constatou-se ainda compreensões diferenciadas a respeito dos conceitos de teoria, adaptação, espécie, seleção natural e acaso, quando comparadas aos conceitos científicos atualmente consagrados. Os estudantes também expressaram uma variedade de visões sobre a ciência que podem estar associadas aos seus conceitos sobre evolução biológica. Neste artigo são discutidas algumas implicações desta pesquisa para o ensino de Ciências e Biologia.</p><p class="URIsumresabsartigo"><strong>Palavras-chave:</strong> evolução biológica; religião; educação científica.<strong></strong></p>
Dynamic Performance of a Back-to-Back HVDC Station Based on Voltage Source Converters (2010)

Dynamic Performance of a Back-to-Back HVDC Station Based on Voltage Source Converters The recent developments in semiconductors and control equipment have made the voltage source converter based high voltage direct current (VSC-HVDC) feasible. This new DC transmission is known as "HVDC Light or "HVDC Plus by leading vendors. Due to the use of VSC technology and pulse width modulation (PWM) the VSC-HVDC has a number of potential advantages as compared with classic HVDC. In this paper, the scenario of back-to-back VSC-HVDC link connecting two adjacent asynchronous AC networks is studied. Control strategy is implemented and its dynamic performances during disturbances are investigated in MATLAB/Simulink program. The simulation results have shown good performance of the proposed system under balanced and unbalanced fault conditions.
Outcome of Vitreous Surgery and the Balance between Vascular Endothelial Growth Factor and Endostatin (2003)

In this study both VEGF and endostatin were expressed in eyes with PDR. VEGF and endostatin levels in the vitreous fluid correlated with the outcome of vitreous surgery for PDR. Therefore, the outcome of PDR surgery can probably be predicted by measuring cytokines and/or growth factors in the vitreous fluid, with VEGF and endostatin being good candidates.
Locally Repairable Codes (2014)

Distributed storage systems for large-scale applications typically use replication for reliability. Recently, erasure codes were used to reduce the large storage overhead, while increasing data reliability. A main limitation of off-the-shelf erasure codes is their high-repair cost during single node failure events. A major open problem in this area has been the design of codes that: 1) are repair efficient and 2) achieve arbitrarily high data rates. In this paper, we explore the repair metric of locality, which corresponds to the number of disk accesses required during a single node repair. Under this metric, we characterize an information theoretic tradeoff that binds together the locality, code distance, and storage capacity of each node. We show the existence of optimal locally repairable codes (LRCs) that achieve this tradeoff. The achievability proof uses a locality aware flow-graph gadget, which leads to a randomized code construction. Finally, we present an optimal and explicit LRC that achieves arbitrarily high data rates. Our locality optimal construction is based on simple combinations of Reed-Solomon blocks.
Kinetic Analysis of δ Ribozyme Cleavage (1998)

The ability of delta ribozyme to catalyze the cleavage of an 11-mer RNA substrate was examined under both single- and multiple-turnover conditions. In both cases only small differences in the kinetic parameters were observed in the presence of either magnesium or calcium as cofactor. Under multiple-turnover conditions, the catalytic efficiency of the ribozyme (kcat/KM) was higher at 37 degreesC than at 56 degreesC. The cleavage reaction seems to be limited by the product release step at 37 degreesC and by the chemical cleavage step at 56 degreesC. We observed substrate inhibition at high concentrations of the 11-mer substrate. Cleavage rate constants were determined with a structural derivative characterized by an ultrastable L4 tetraloop. The kinetic parameters (kcat and KM) and dissociation constant (Kd) were almost identical for both ribozymes, suggesting that the stability of the L4 loop has a negligible impact on the catalytic activities of the examined ribozymes. Various cleavage inhibition and gel-shift assays with analogues, substrate, and both active and inactive ribozymes were performed. The 2'-hydroxyl group adjacent to the scissile phosphate was shown to be involved in binding with the ribozyme, while the essential cytosine residue of the J4/2 junction was shown to contribute to substrate association. We clearly show that substrate binding to the delta ribozyme is not restricted to the formation of a helix located downstream of the cleavage site. Using these results, we postulate a kinetic pathway involving a conformational transition step essential for the formation of the active ribozyme/substrate complex.
Diversification and co‐option of RAD‐like genes in the evolution of floral asymmetry (2007)

To understand how changes in gene regulatory networks lead to novel morphologies, we have analysed the evolution of a key target gene, RAD, controlling floral asymmetry. In Antirrhinum, flower asymmetry depends on activation of RAD in dorsal regions of the floral meristem by the upstream regulators CYC and DICH. We show that Arabidopsis, a species with radially symmetric flowers, contains six RAD-like genes, reflecting at least three duplications since the divergence of Antirrhinum and Arabidopsis. Unlike the situation in Antirrhinum, none of the Arabidopsis RAD-like genes are activated in dorsal regions of the flower meristem. Rather, the RAD-like genes are expressed in distinctive domains along radial or ab-adaxial axes, consistent with a range of developmental roles. Introduction of a RAD genomic clone from Antirrhinum into Arabidopsis leads to a novel expression pattern that is distinct from the expression pattern of RAD in Antirrhinum and from the endogenous RAD-like genes of Arabidopsis. Nevertheless, RAD is able to influence developmental targets in Arabidopsis, as ectopic expression of RAD has developmental effects in this species. Taken together, our results suggest that duplication and divergence of RAD-like genes has involved a range of cis- and trans-regulatory changes. It is possible that such changes led to the coupling of RAD to CYC regulation in the Antirrhinum lineage and hence the co-option of RAD had a role in the generation of flower dorsoventral asymmetry.
The reflex cardiovascular depression caused by occlusion of the coronary sinus in the dog (1972)

1. Brief occlusions of the outflow from the cannulated coronary sinus in the open chest anaesthetized dog caused a rise in coronary venous pressure, bradycardia, and systemic hypotension.2. The bradycardia and hypotension were directly proportional to the peak systolic coronary venous pressures above a threshold value of about 50 mm Hg.3. The bradycardia, but not the systemic hypotension, was abolished by intravenous atropine. Both responses were abolished by cutting the cervical vagi, and reversibly abolished by cooling them to less than 7 degrees C.4. During occlusions, there was inhibition of activity in single and small multi-fibre preparations of sympathetic efferent nerves in the ansae subclaviae and the cervical sympathetic.5. On the right side, nearly all afferent fibres ran in the recurrent cardiac nerve. There was no concentration of afferents in one cardiac nerve on the left side.6. It was concluded that the cardiovascular depression was reflex, and was caused by the stimulation of nerves or nerve endings in the ventricles of the heart.
Expression of metalloproteinase‐7 (matrilysin) in human blood and bronchoalveolar Gamma/Delta T‐lymphocytes. Selective upregulation by the soluble non‐peptidic mycobacterial phosphoantigen (isopentenyl pyrophosphate) (2005)

Human gammadelta T-lymphocytes are believed to regulate local immune defense and enhance resistance against invading microbes, although their precise function remains unknown. Herein, we addressed the question whether gammadelta T-lymphocytes mediate these processes via synthesis of MMP-7, a protease closely associated with both epithelial repair and mucosal defense. Blood and bronchoalveolar gammadelta T-lymphocytes were cultured in the absence and presence of isopentenyl pyrophosphate (IPP) or TGF-beta1/IL-15 for 24 h, and assessed for the expression and synthesis of MMP-1, MMP-7, and MMP-9. Resting human gammadelta T-lymphocytes constitutively expressed MMP-9 mRNA, a marginal or no MMP-7 and MMP-1 mRNA. In the presence of IPP (3 microg/ml), expression of MMP-7 mRNA significantly increased, whereas TGF-beta1/IL-15 had no effect. Further, quiescent gammadelta T-lymphocytes obtained from bronchoalveolar lavage (BAL) fluid showed a weak or no MMP-7 mRNA signal which was raised significantly following stimulation with IPP. In Western blot analysis, a 28-kDa pro-matrilysin could be detected both in cell lysates (2 days) and supernatants (5 days) with a four- to sevenfold increased signal following IPP-stimulation of the gammadelta T-lymphocytes. In conclusion, the data demonstrate for the first time that both human blood and BAL gammadelta T-lymphocytes express MMP-7 mRNA and synthesize MMP-7-protein. This unfolds a new perspective for the understanding of gammadelta T-lymphocyte function.
Visual3: A software environment for flow visualization (1991)

A graphics environment has been developed for the visualization of three-dimensional engineering and scientific data. Unlike existing packages, it can handle a wide variety of structured and unstructured grids, and deals with generic scalar and vector data, making it suitable for a wide range of physical applications. An important feature of the package is the ability to view unsteady data in either post-processing or co-processing modes. Another unique aspect of Visual3 is the dimensional windowing approach coupled with cursor mapping which allows efficient pointing in 3D space. There is also a strong emphasis on a wide variety of `probes&apos; allowing the user to interactively investigate the computational data. In that this is a discussion of an interactive visualization environment, these notes cannot be considered complete without a live demonstration of Visual3. NOTE: Sections of these notes have been extracted from [1] [2] [3] and [4]. Contents 1 Introduction 4 2 Visual3 Archite...
Chaos in a Plasma-Filled Diode in the Presence of a Magnetic Field (2006)

Many investigations have shown that microwave generators, being highly nonlinear, are capable of generating chaos. Through our own investigations into the problem of generating chaos in a plasma-filled diode in the presence of a magnetic field, it has been found that the magnetic field plays an important role in the changing the imbalance between electrons and ions, which leading to chaos.
DNA damage recognition and incision by the UvrABC proteins of Bacillus subtilis. (2002)

Available from British Library Document Supply Centre- DSC:DXN061603 / BLDSC - British Library Document Supply Centre
Human cationic trypsinogen. Purification, characterization, and characteristics of autoactivation. (1978)

Human pancreatic cationic trypsinogen has been purified to homogenity from an acetone powder of pancreatic tissue. After an initial ion exchange chromatography step on sulfopropyl (SP)-Sephadex at pH 2.6, cationic trypsinogen was separated from the majority of trypsin activity by passage through an affinity column of lima bean trypsin inhibitor-agarose at high ionic strength. The zymogen was then further purified by affinity chromatography on the same material at low ionic strength. Highly purified trypsinogen was resolved from containing chymotrypsinogen by ion exchange chromatography on SP-Sephadex at pH 6.0. The purified zymogen was shown to be homogeneous by polyacrylamide gel electrophoresis at pH 2.1 and at pH 4.3 as well as by discontinuous sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The autoactivation of human trypsinogen was investigated at pH 5.6 and at pH 8.0. The rate of autoactivation of the human zymogen is rapid at pH 5.6 and is maximal in approximately 1 mM Ca2+. These results are in marked contrast to those previously reported for autoactivation of bovine trypsinogen, which is extremely slow at pH 5.6 and which shows a dependence on at least 50 mM Ca2+ for maximum rate of activation (MacDonald, M. R., AND Kunitz, M. (1941) J. Gen. Physiol. 25, 53-73).
Intra-day up and down of flux density at 4.8 GHz of the quasar S5 1044+71 (2014)

Following ATEL #5869, we observed the quasar S5 1044+71 at 4.8 GHz in two Intra-day variability (IDV) sessions with the Urumqi 25m radio telescope of Xinjiang Astronomical Observatory (XAO), we find its flux is rising by ~4% on 11-12 Feb. ...