gebhart/patrepeval huggingface dataset:
Favorable Effects of Blue-Green Algae Aphanizomenon flos-aquae on Rat Plasma Lipids (2000)

Background: Polyunsaturated fatty acids (PUFAs) are essential for human health. There are indications that the lipid fraction of blue-green algae Aphanizomenon flosaquae contains about 50% PUFA and may be a good dietary source of PUFA. The purpose of this study was to investigate the effect of diets supplemented with algae on blood plasma lipids. Methods: Rats were fed with four different semisynthetic diets: 1) standard, with 5% soybean oil; 2) PUFA-free with 5% coconut oil; 3) PUFA-free with 10% algae; 4) PUFA-free with 15% algae. After 32 days the levels of plasma fatty acids, triglycerides, and cholesterol were studied. Results: Rats fed the PUFA-free diet demonstrated an absence of linolenic acid (LNA) in plasma; however, supplementation with algae resulted in the same level of LNA as controls, increased levels of eicosapentaenoic acid and docosahexaenoic acid, and a decreased level of arachidonic acid. Dietary supplementation with 10% and 15% algae decreased the plasma cholesterol to 54% and 25% of the control level, respectively (p<0.0005). Plasma triglyceride levels decreased significantly (p<0.005) after diet supplementation with 15% algae. Conclusion: Algae Aphanizomenon flos-aquae is a good source of PUFA and because of potential hypocholesterolemic properties should be a valuable nutritional resource.
Two-Point Focused Laser Differential Interferometry Second-Mode Measurements at Mach 6 (2019)

A two-point focused laser differential interferometer (FLDI) is used to make measurements of density fluctuations on a 7 degree half-angle cone in a Mach 6 flow. The system was first characterized in the laboratory using laser induced breakdown to provide a well defined density fluctuation. The speed of the shock wave generated by the breakdown is verified using simultaneous high-speed schlieren. The FLDI system is then installed at the NASA Langley 20-Inch Mach 6 air tunnel to make measurements in the boundary layer of the 7 degree half-angle cone model and in the tunnel freestream for a unit Reynolds number range of 3.0 to 8.22 x 10(exp 6)/ft. Second-mode packets are visible in the spectra, with peak frequencies increasing linearly and peak amplitude increasing as a function of unit Reynolds number. The two-point measurement allows for the calculation of the second-mode wavepacket speeds, which propagate between 88% and 92% of the freestream velocity of the tunnel for all Reynolds numbers. The FLDI measurements are compared to surface-mounted fast-response pressure transducer measurements, where second-mode frequencies and wavepacket speeds are in good agreement.
Human Rad52 protein promotes single-strand DNA annealing followed by branch migration (1997)

In the yeast, Saccharomyces cerevisiae, the Rad52 gene is important for both mitotic and meiotic recombination. Homologs of the Rad52 gene have been identified in several eukaryotic organisms, ranging from yeast to man. As reported here, human Rad52 protein binds to both single- and double-stranded DNA; and acting on a pair of single-stranded and partially duplex substrates it promotes annealing of complementary strands of DNA, which is followed by branch migration.
Helping out by helping in: approaches to electronic submission of coursework (2001)

Many teaching contexts require mass submission of coursework. Often, this entails significant overheads on staff and secretarial support. The submission procedure, largely due to its deadline nature, also imposes pressures on students. Educators often have experience of student work compromised as a result of
Protein Kinase C θ Is Critical for the Development of In Vivo T Helper (Th)2 Cell But Not Th1 Cell Responses (2004)

The serine/threonine-specific protein kinase C (PKC)-theta is predominantly expressed in T cells and localizes to the center of the immunological synapse upon T cell receptor (TCR) and CD28 signaling. T cells deficient in PKC-theta exhibit reduced interleukin (IL)-2 production and proliferative responses in vitro, however, its significance in vivo remains unclear. We found that pkc-theta(-/-) mice were protected from pulmonary allergic hypersensitivity responses such as airway hyperresponsiveness, eosinophilia, and immunoglobulin E production to inhaled allergen. Furthermore, T helper (Th)2 cell immune responses against Nippostrongylus brasiliensis were severely impaired in pkc-theta(-/-) mice. In striking contrast, pkc-theta(-/-) mice on both the C57BL/6 background and the normally susceptible BALB/c background mounted protective Th1 immune responses and were resistant against infection with Leishmania major. Using in vitro TCR transgenic T cell-dendritic cell coculture systems and antigen concentration-dependent Th polarization, PKC-theta-deficient T cells were found to differentiate into Th1 cells after activation with high concentrations of specific peptide, but to have compromised Th2 development at low antigen concentration. The addition of IL-2 partially reconstituted Th2 development in pkc-theta(-/-) T cells, consistent with an important role for this cytokine in Th2 polarization. Taken together, our results reveal a central role for PKC-theta signaling during Th2 responses.
Modelling of lithium-ion battery for online energy management systems (2012)

This study presents a new equivalent lithium-ion (Li-ion) battery model for online energy management system. It has an equilibrium potential E and an equivalent internal resistance Rint. The equilibrium potential E is expressed as a function of state-of-charge (SOC), current and temperature. The equivalent internal resistance Rint includes R1 and R2. R1 is defined as the resistance, which can be formulated by the discharging current and temperature. R2 is defined as the resistance which is because of the change of temperature. The adaptive extended Kalman filter is employed to implement the online energy management system based on the proposed Li-ion battery model. The SOC is considered as the state variable for the charging or discharging process of the Li-ion battery. The covariance parameters of the processing noise and observation errors are updated adaptively. The SOC of the Li-ion battery can be predicted by the online measured voltage and current in the online energy management system. The effectiveness and robustness of the proposed Li-ion battery model is validated. Experimental results show that the estimated SOC is accurate for various operating conditions. A comparison between the proposed method and other SOC estimation methods is also shown in the experimental results and analysis section.
Triboelectric Balls as Three-Dimensional Vibrational Energy Harvesters and Self-Powered Sensors (2018)

Ball shaped structure, due to its 3D symmetricity, provides unique advantages in applications of energy harvesting from diverse energy sources and sensing of complicated physical motions. In this work, we integrate the ball shaped structure with triboelectric mechanism as a platform for large variety of energy harvesting and self-powered sensing applications. Two different types of triboelectric nanogenerator ball (TENG-Ball) with encapsulated steel ball or water as the movable mass are proposed and investigated. Both devices are capable of harvesting energy from various ambient energy sources, such as multi-direction vibration, spinning, rotation, rolling, and human motions, etc. The steel ball based TENG- Ball is first characterized as self-powered multi-axis acceleration and rotation sensor, and then further demonstrated for human activity monitoring and gesture recognition applications. The water based TENG-Ball, due to its robustness even in water environment, is characterized as water wave energy harvester and self-powered fishing sensor on water surface.
Information theoretic inequalities (1991)

The role of inequalities in information theory is reviewed, and the relationship of these inequalities to inequalities in other branches of mathematics is developed. The simple inequalities for differential entropy are applied to the standard multivariate normal to furnish new and simpler proofs of the major determinant inequalities in classical mathematics. The authors discuss differential entropy inequalities for random subsets of samples. These inequalities when specialized to multivariate normal variables provide the determinant inequalities that are presented. The authors focus on the entropy power inequality (including the related Brunn-Minkowski, Young's, and Fisher information inequalities) and address various uncertainty principles and their interrelations.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Substitution of the U3 long terminal repeat region of the neurotropic Cas-Br-E retrovirus affects its disease-inducing potential (1990)

The Cas-Br-E and ts-Mo BA-1 murine leukemia viruses (MuLV) induce a spongiform neurodegenerative disease with different clinical manifestations, namely, either hind limb paralysis (Cas-Br-E) or tremors, spasticity, and hind limb weakness (ts-Mo Ba-1). We constructed the chimeric NEBA-1 MuLV by replacing the long terminal repeat of Cas-Br-E MuLV with that of ts-Mo BA-1 MuLV. In SWR/J or CFW/D mice, NEBA-1 MuLV induced an ataxic neurological disease characterized by clinical signs different from those induced by both parents. Although NEBA-1 MuLV did not induce lesions in novel brain areas, the spongiform lesions were more severe in deep cerebellar nuclei and in the spinal cord than those found in paralyzed mice inoculated with Cas-Br-E MuLV. By in situ hybridization, we found that the distribution of the spongiform lesions closely correlated with the distribution of the infected central nervous system cells. In the spinal cord, a close correlation was found between the number of infected cells and the severity of the spongiform degeneration. Sequencing of the substituted ts-BA-1 MuLV fragment and comparison with homologous sequences of Cas-Br-E and Moloney MuLV showed differences mainly in the U3 tandem direct repeats. Our results show that a few modifications within the U3 long terminal repeat allow the virus to cause more severe lesions in some central nervous system regions and that the severity of the spongiform degeneration correlates with the level of viral replication.
Securing Roaming and Vertical Handover in Fourth Generation Networks (2009)

Wireless 4G networks are the result of the interconnection of different wireless access networks and a core network. The heterogeneity of 4G networks require the implementation of a vertical authentication scheme that reduces the handover delay while preserving the security context of the ongoing communication. This paper proposes a complete vertical authentication scheme integrating the GSM, UMTS, WiFi and WiMAX technologies that enables a vertical handover without requiring a prior subscription to the visited network. We also prove the immunity of our scheme against some heterogeneous attacks.
Preparation of polyphosphazenes: a tutorial review (2016)

Poly(organo)phosphazenes are a family of inorganic molecular hybrid polymers with very diverse properties due to the vast array of organic substituents possible. This tutorial review aims to introduce the basics of the synthetic chemistry of polyphosphazenes, detailing for readers outside the field the essential knowledge required to design and prepare polyphosphazenes with desired properties. A particular focus is given to some of the recent advances in their chemical synthesis which allows not only the preparation of polyphosphazenes with controlled molecular weights and polydispersities, but also novel branched architectures and block copolymers. We also discuss the preparation of supramolecular structures, bioconjugates and in situ forming gels from this diverse family of functional materials. This tutorial review aims to equip the reader to prepare defined polyphosphazenes with unique property combinations and in doing so we hope to stimulate further research and yet more innovative applications for these highly interesting multifaceted materials.
Human Tracking Method Based on Maximally Stable Extremal Regions with Multi-Cameras (2010)

With respect to the human tracking with multi-cameras in the video surveillance system, a human tracking method based on MSER (Maximally Stable Extremal Regions) was established. The approach transforms the human tracking into elliptic region matching. The method does elliptic region fitting to each MSER, and then selects the elliptic regions which meet some constraints. These selected elliptic regions are normalized to unity circular regions. The right matched elliptic regions are gotten by rotational invariant vectors calculation, histogram density estimation and weighted average distance calculation. Experimental results show that the approach can effectively realize the human tracking with multi-cameras.
Biometry: The Principles and Practice of Statistics in Biological Research (1969)

1. Introduction 2. Data in Biology 3. Computers and Data Analysis 4. Descriptive Statistics 5. Introduction to Probability Distributions 6. The Normal Probability Distribution 7. Hypothesis Testing and Interval Estimation 8. Introduction to Analysis of Variance 9. Single-Classification Analysis of Variance 10. Nested Analysis of Variance 11. Two-Way and Multiway Analysis of Variance 12. Statistical Power and Sample Size in the Analysis of Variance 13. Assumptions of Analysis of Variance 14. Linear Regression 15. Correlation 16. Multiple and Curvilinear Regression 17. Analysis of Frequencies 18. Meta-Analysis and Miscellaneous Methods
The correlation of body growth with diethylnitrosamine-induced hepatocarcinogenesis in relation to serum insulin and somatomedin-C (1991)

Caloric restriction depresses the development of several types of tumours, yet the mechanisms involved are poorly understood. In the present experiment we investigated the development of diethylnitrosamine (DEN)-induced liver tumours in mice treated with caffeine. The latter was found to reduce body growth, possibly due to increased energy expenditure, without reducing food consumption. Newborn mice received an i.p. injection of DEN. At weaning they were either fed lab chow ad libitum, with the same diet containing 0.2% (w/w) of caffeine, or their access to food was restricted to 70% of that consumed by the ad libitum group. Diet caloric restriction starting at weaning in male Swiss mice decreased the rate of development of glucose-6-phosphatase-deficient (G6Pd) preneoplastic foci. At the age of 24 weeks, 10% of the surface of a standardized liver section of ad libitum fed mice was G6Pase negative, compared to only 1% in the restricted mice due to a reduction of the number and size of these preneoplastic foci. The number and size of G6Pd foci decreased to the same extent with the ingestion of a lab chow supplemented with 0.2% of caffeine as with the diet restriction. This finding suggests that restriction slows down hepatic tumour growth by modifying body growth rather than by limited nutrient supply. In parallel, somatomedin-C (Sm-C) and insulin secretion following glucose challenge were decreased in diet restricted mice and those treated with 0.2% caffeine. The serum Sm-C and insulin levels were respectively 480 and 4.6 ng/ml in the restricted mice, 519 and 16.6 ng/ml in the caffeine-fed mice and 664 and 25.7 ng/ml in the ad libitum fed mice. Our results suggest that the decrease of secretion of these two hormones that are known mitogens for hepatocytes in vitro may be responsible at least in part for the reduction in the growth of liver tumours.
The neonatal oxycardiorespirogram. (1984)

The neonatal oxycardiorespirogram is the simultaneous recording of respiration rate, respiration waveform, instantaneous heart rate, transcutaneous oxygen tension, and relative skin perfusion or "blood flow" from newborn infants. It is important in monitoring the high risk infant to assess the cardiovascular and respiratory function of the patient. The techniques for obtaining the various signals of the oxycardiorespirogram are reviewed and the usual method for making this recording is presented. Several examples of typical oxycardiorespirograms are given.
Innovation, Skill Diffusion, and Social Exclusion (2001)

Abstract This chapter examines three issues: innovation, skill diffusion, and exclusion in relation to education and training systems and the labour market. It argues that while little attention has been paid in the past to the analysis of national systems of skill diffusion, it is hoped that the research reported here demonstrates the importance of this particular field of study. It also discusses the absence of intermediate institutions in flexible labour markets, and the Singaporean case which throws into sharp relief two key issues relating to initial training that aims to be at the cutting edge. These have to do with how students gain access to what is often very expensive and sophisticated equipment and how this is to be resourced.
Analysis of the Mechanism by Which Glucose Inhibits Maltose Induction of MAL Gene Expression in Saccharomyces (2000)

Expression of the MAL genes required for maltose fermentation in Saccharomyces cerevisiae is induced by maltose and repressed by glucose. Maltose-inducible regulation requires maltose permease and the MAL-activator protein, a DNA-binding transcription factor encoded by MAL63 and its homologues at the other MAL loci. Previously, we showed that the Mig1 repressor mediates glucose repression of MAL gene expression. Glucose also blocks MAL-activator-mediated maltose induction through a Mig1p-independent mechanism that we refer to as glucose inhibition. Here we report the characterization of this process. Our results indicate that glucose inhibition is also Mig2p independent. Moreover, we show that neither overexpression of the MAL-activator nor elimination of inducer exclusion is sufficient to relieve glucose inhibition, suggesting that glucose acts to inhibit induction by affecting maltose sensing and/or signaling. The glucose inhibition pathway requires HXK2, REG1, and GSF1 and appears to overlap upstream with the glucose repression pathway. The likely target of glucose inhibition is Snf1 protein kinase. Evidence is presented indicating that, in addition to its role in the inactivation of Mig1p, Snf1p is required post-transcriptionally for the synthesis of maltose permease whose function is essential for maltose induction.
Amino acid replacements resulting from suppression and missense reversion of a chain-terminator mutation in Neurospora. (1977)

The Neurospora crassa super-suppressor mutation, ssu-1, suppresses the auxotrophic phenotype of the mutant am(17) by inserting tyrosine at residue 313 of NADP-specific glutamate dehydrogenase, a position occupied in the wild type by glutamate. Two classes of am(17) revertants due to further mutation within the am gene have, respectively, tyrosine and leucine at residue 313. These replacements are consistent with a chain-terminating codon in am(17) of either the amber (UAG) or the ochre type (UAA), but are inconsistent with UGA. The Leu313 and Tyr313 variants of the enzyme have effective activity but are grossly different from the wild type in Michaelis constants (especially for ammonium) and heat stabilities at two different pH values. They show smaller but significant differences in these respects from each other.
Technical-Scale Production of Cyanophycin with Recombinant Strains of <i>Escherichia coli</i> (2002)

By the use of Escherichia coli DH1 harboring cphA from Synechocystis sp. strain PCC6803, large-scale production of cyanophycin at 30- and 500-liter culture volumes was established. Transcription of cphA was controlled by the thermosensitive cI857 repressor, which enabled induction of cphA by a simple temperature shift in the culture fluid. Maximum cyanophycin cell content of up to 24% (wt/wt) of cellular dry matter was obtained by induction in the early exponential growth phase and cultivation of the cells in terrific broth complex medium. Synthesis of cyanophycin was found to be strongly dependent on the presence of complex components, and in mineral salts medium the cells synthesized and accumulated cyanophycin only if Casamino Acids were added. Cultivations were done at the 500-liter scale, allowing the provision of cell mass for the preparation of cyanophycin at the kilogram scale. Isolation of cyanophycin was achieved by a new acid extraction procedure which allowed large-scale purification of the polyamide from whole cells.
A <i>Drosophila</i> gene is subject to glucose repression (1987)

Amylase-specific cDNA probes were used to assay amylase mRNA levels in third-instar larvae of Drosophila melanogaster. It is shown that there is a difference, of the order of 100-fold, in the mRNA levels between larvae that are fed 10% glucose and larvae of the same wild-type strain that are fed an equivalent diet lacking glucose. In fact, the glucose-fed larvae have barely detectable levels of amylase mRNA. This large difference in transcript abundance indicates that the glucose effect, which we previously characterized at the level of enzyme activity, probably reflects a change in the transcriptional activity of the amylase gene.
Morphological Transformation in Esophageal Submucosa by Bone Marrow Cells: Esophageal Implantation under External Esophageal Perfusion (2006)

Accumulating clinical and experimental studies indicate that Barrett's esophagus might arise through multipotential stem cells under the stress of gastroesophageal reflux. Previously, we have presented a novel external pump perfusion rat model and demonstrated that perfusion with both acid and bile can induce severe esophagitis in 1 week with a similarly pathological change seen in humans. The aim of this study was to investigate the histological changes of esophagus after bone marrow cell engraftment with bile and acid perfusion. The external pump perfusion procedure involved implantation of a microosmotic pump for esophageal perfusion. Bone marrow cells were obtained by flushing of the femur marrow, and the cell suspension was injected between the esophageal muscular and inner mucosa layer. Histological changes were determined after 4 weeks of perfusion. Proliferating cell nuclear antigen, 8-hydroxy-deoxyguanosine, manganese superoxide dismutase, and apoptosis were measured by immunohistochemical staining and TUNEL assay, respectively. Severe esophagitis was seen in both acid and bile perfusion. Bone marrow engraftment and potentiation was seen in both the acid and bile perfusion, when compared to saline controls. Glandular-like cells in submucosa, consistent with intestinal metaplasia, confirmed by Alcin Blue-PAS staining were observed after bone marrow esophageal implantation along with bile perfusion, but not with acid perfusion and controls. Bone marrow implantation in conjunction with esophageal reflux injury contributes to abnormal histological changes consistent with early Barrett's esophageal changes. Engrafted bone marrow cells proliferate under oxidative stress conditions with bile perfusion.
Quantum Dot Applications to Neuroscience: New Tools for Probing Neurons and Glia (2006)

Editor’s Note: Toolboxes are a new, occasional feature in the Journal designed to briefly highlight a new method or a resource of general use in neuroscience or to critically analyze existing approaches or methods. For more information, see <http://www.jneurosci.org/misc/itoa.shtml>.