gebhart/patrepeval huggingface dataset:
FPGA Design Considerations in the Implementation of a Fixed-Throughput Sphere Decoder for MIMO Systems (2006)

A field-programmable gate array (FPGA) implementation of a new detection algorithm for uncoded multiple input-multiple output (MIMO) systems based on the complex version of the sphere decoder (SD) is presented in this paper. It achieves quasi-maximum likelihood (ML) performance in systems where a hardware implementation of the maximum likelihood detector (MLD) is unfeasible due to its high complexity. It achieves this with a highly parallel and fully pipelined architecture. In addition, different design modifications are proposed and implemented to reduce the resource use and/or increase the throughput of the algorithm
Phase I safety study of escalating doses of atrasentan in adults with recurrent malignant glioma (2008)

Atrasentan is an oral selective endothelin-A receptor antagonist that may inhibit cell proliferation and interfere with angiogenesis during glioma growth. We conducted a dose-finding study to assess atrasentan's safety and toxicity and to gather preliminary evidence of efficacy. Patients with recurrent malignant glioma received oral atrasentan at >or=10 mg/day. We increased the dose among cohorts until the maximum tolerated dose (MTD) was defined. Patients were evaluated for response every 8 weeks and remained on the study until the tumor progressed or toxicities occurred. Twenty-five patients were enrolled, with a median age of 53 years (range, 25-70) and a median KPS of 90% (range, 60-100%). Twenty-two patients had glioblastoma multiforme (GBM), 2 had anaplastic astrocytoma, and 1 had an anaplastic oliogodendroglioma; 24 patients had received one prior chemo therapy regimen before being enrolled in the study. The most common atrasentan-related toxicities were grade 1 or 2 rhinitis, fatigue, and edema. One patient developed grade 3 hypoxia and peripheral edema at a dose of 90 mg/day. We observed no dose-limiting toxicities in an expanded cohort of 10 patients at 70 mg/day, which was declared the MTD. Two partial responses (8%) were seen in patients with GBM at the 70- and 90-mg/day dose levels, and 4 patients had stable disease before progressing. Nineteen patients have died, and median survival was 6.0 months (95% confidence interval, 4.2-9.5 months). We conclude that the MTD of daily oral atrasentan in patients with recurrent malignant glioma is 70 mg/day. Further study of atrasentan with radiation therapy and temozolomide in newly diagnosed GBM is warranted to evaluate the efficacy of this novel agent.
O espaço de transição de falantes em audiências de conciliação no procon: Lugar relevante para o desacordo? (2015)

The study explores aspects of the organization from the turns of speak and conversational sequence in Analysis of the Ethnic methodological Colloquy to argue the process of transition from speakers in meetings of conciliation in PROCON. The examination of some practical of taking from turn in this scene discloses an accomplishment anticipated of disagreement acts, in not excellent places for the transition from speakers. Such characteristic must over all to the conflict context, where the disagreement act gains prominence in the interaction. It is corroborated, finally, the Gruber perspective (1998), according to which, in determined conflict contexts, can be spoken in an excellent place for the disagreement.
N-substituted piperazinopyridylsteroid derivatives as abiraterone analogues inhibit growth and induce pro-apoptosis in human hormone-independent prostate cancer cell lines. (2013)

International audience
A planar capacitive precision gauge for liquid-level and leakage detection (1997)

A new capacitive precision liquid-level gauge has been developed. The sensor consists of a low-cost planar electrode structure, a capacitance-controlled oscillator and a microcontroller. The device is able to measure absolute levels of conducting and nonconducting liquids with a 1 mm uncertainty over a 4 m range. The system has a high resolution of 0.1 mm at short measuring times of only 0.2 s. Slow level movements of 0.02 mm/h can be detected within 18 min.
Bayesian multi-camera surveillance (2003)

The task of multicamera surveillance is to reconstruct the paths taken by all moving objects that are temporally visible from multiple non-overlapping cameras. We present a Bayesian formalization of this task, where the optimal solution is the set of object paths with the highest posterior probability given the observed data. We show how to efficiently approximate the maximum a posteriori solution by linear programming and present initial experimental results.
Richer File System Metadata Using Links and Attributes (2005)

Traditional file systems provide a weak and inadequate structure for meaningful representations of file interrelationships and other context-providing metadata. Existing designs, which store additional file-oriented metadata either in a database, on disk, or both are limited by the technologies upon which they depend. Moreover, they do not provide for user-defined relationships among files. To address these issues, we created the linking file system (LiFS), a file system design in which files may have both arbitrary user- or application-specified attributes, and attributed links between files. In order to assure performance when accessing links and attributes, the system is designed to store metadata in non-volatile memory. This paper discusses several use cases that take advantage of this approach and describes the user-space prototype we developed to test the concepts presented.
The E.164 to Uniform Resource Identifiers (URI) Dynamic Delegation Discovery System (DDDS) Application (ENUM) (2004)

This document discusses the use of the Domain Name System (DNS) for storage of E.164 numbers. More specifically, how DNS can be used for identifying available services connected to one E.164 number. It specifically obsoletes RFC 2916 to bring it in line with the Dynamic Delegation Discovery System (DDDS) Application specification found in the document series specified in RFC 3401. It is very important to note that it is impossible to read and understand this document without reading the documents discussed in RFC 3401.
High Q SAW resonator using upper-electrodes on grooved-electrodes in LiTaO3 (2010)

Summary form only given. Al-electrodes on 36-48°YX-LiTaO3 substrates have been widely used in surface acoustic wave (SAW) filters and SAW duplexers because of having an optimum electro-mechanical coupling factor, reflection coefficient and good Q-factor. In this paper, authors proposed and constructed a new SAW structure composed of upper Al-electrodes accumulated on lower grooved Cu-electrodes in the LiTaO3 substrate, which has approximately same electro-mechanical coupling factor and reflection coefficient as the Al-electrodes (thickness of 0.1lambda)/36-48°YX-LiTaO3 in order to realize high Q-factor. As the result, the SAW resonator having superior Q-factor was realized compared with that of Al-electrodes(0.1lambda)/42°YX-LiTaO3 substrates.
Structural Basis of Mechanochemical Coupling in a Hexameric Molecular Motor (2007)

The P4 protein of bacteriophage phi12 is a hexameric molecular motor closely related to superfamily 4 helicases. P4 converts chemical energy from ATP hydrolysis into mechanical work, to translocate single-stranded RNA into a viral capsid. The molecular basis of mechanochemical coupling, i.e. how small approximately 1 A changes in the ATP-binding site are amplified into nanometer scale motion along the nucleic acid, is not understood at the atomic level. Here we study in atomic detail the mechanochemical coupling using structural and biochemical analyses of P4 mutants. We show that a conserved region, consisting of superfamily 4 helicase motifs H3 and H4 and loop L2, constitutes the moving lever of the motor. The lever tip encompasses an RNA-binding site that moves along the mechanical reaction coordinate. The lever is flanked by gamma-phosphate sensors (Asn-234 and Ser-252) that report the nucleotide state of neighboring subunits and control the lever position. Insertion of an arginine finger (Arg-279) into the neighboring catalytic site is concomitant with lever movement and commences ATP hydrolysis. This ensures cooperative sequential hydrolysis that is tightly coupled to mechanical motion. Given the structural conservation, the mutated residues may play similar roles in other hexameric helicases and related molecular motors.
Vonoprazan, a novel potassium-competitive acid blocker, as a component of first-line and second-line triple therapy for <i>Helicobacter pylori</i> eradication: a phase III, randomised, double-blind study (2016)

NCT01505127.
Treatment of irritable bowel syndrome: beyond fiber and antispasmodic agents (2010)

Irritable bowel syndrome (IBS) is a chronic functional disorder of the gastrointestinal tract of unknown etiology. The diagnosis of IBS is made clinically, using symptom-based criteria such as the Manning or Rome criteria. Medical therapy for this condition has traditionally been directed towards symptom relief, using fiber or antispasmodic agents. In recent years, emerging data have confirmed the efficacy of antidepressants, psychological therapies, 5-HT(3) antagonists, 5-HT(4) agonists, and probiotics in the short-term treatment of IBS, although whether these therapies influence the long-term course of the disease is unknown. Increasing knowledge regarding the pathophysiological mechanisms underlying IBS has resulted in a number of novel molecular treatments, which show promise. These include therapies targeting gastrointestinal mucosal chloride channels and guanylate cyclase-C receptors, as well as highly selective agents influencing serotonergic transmission that, at the time of writing, do not appear to have any severe deleterious effects. In this article we provide a summary of current and emerging therapies in this field.
Invited Commentary:Superoxide, Iron, Vascular Endothelium and Reperfusion Injury (1989)

It is proposed that vascular endothelium has an intrinsic capacity to generate O2- for regulatory purposes such as inactivation of endothelium-derived relaxing factor. Ischaemia can disrupt the functioning of this oxidant-generating system, resulting in greater O2- generation when O2 is restored. Ischaemia-induced cellular injury can also lead to release of iron ions, that, upon reperfusion, cause conversion of O2- and H2O2 to powerfully-oxidizing species (such as .OH) that further injure the endothelium.
GaN-Based Light-Emitting Diode with Indium–Tin–Oxide and Vertical Electrode (2005)

A sapphire-etched vertical-electrode nitride semiconductor (SEVENS) light-emitting diode (LED) is fabricated by a selective wet-etching technique. The SEVENS-LED has an indium–tin–oxide (ITO) transparent metal electrode (TME) and a sapphire via hole. The SEVENS-LED exhibits excellent device performances compared with a lateral-electrode (LE) GaN-based LED formed on a sapphire substrate. The light-output power of the SEVENS-LED is ∼7 mW at a 20 mA junction current, which means 13% external quantum efficiency (EQE). The electrostatic discharge (ESD) test shows excellent ESD characteristics of the SEVENS-LED compared with those of the ITO LE-LED. The reverse ESD amplitude of SEVENS-LED is approximately 200 V, which is two times higher than that (∼100 V) of the ITO LE-LED. These improvements of ESD properties are attributed to the change of the lateral electrode to a vertical electrode, without requiring the transfer of the sapphire substrate to a conducting substrate.
Increased serum pigment epithelium‐derived factor is associated with microvascular complications, vascular stiffness and inflammation in Type 1 diabetes<sup>1</sup> (2007)

In Type 1 diabetes, serum PEDF levels are associated with microvascular complications, poor vascular health, hyperglycaemia, adiposity and inflammation.
Effect of Milk Fermented with<i>Lactobacillus acidophilus</i>Strain L-92 on Symptoms of Japanese Cedar Pollen Allergy: A Randomized Placebo-Controlled Trial (2005)

A placebo-controlled, single-blind study was conducted to evaluate the effects of Lactobacillus acidophilus strain L-92 (L-92) on the symptoms of Japanese cedar-pollen allergy. This study was carried out during the 2002 and 2003 seasons of Japanese cedar pollination. Twenty-three in-house volunteers were asked to drink 100 ml of heat-treated milk fermented with L-92 containing 5 x 10(10) of the bacteria, twice a day, for 6 consecutive weeks. A similar study was carried out during the 2003 season for 10 weeks, but the daily dose of bacteria was 2 x 10(10). A significant improvement of the ocular symptom-medication score (SMS) was observed in 2002 and of the score of distress of life in 2003. These data show that a daily oral intake of not less than 2 x 10(10) heat-treated L-92 cells improved the symptoms of Japanese cedar pollinosis, thereby contributing to reduce the dose of concomitant medications. However, no blood parameter was significantly affected in these trials.
REVIEWS I Am a Process with No Subject. By BEITCHMANPHILIP. (University of Florida Humanities Monographs, 61). publisher-loc, University of Florida Press, 1988. x + 310pp. $30.00. (1990)

REVIEWS Get access I Am a Process with No Subject. By PHILIP BEITCHMAN. (University of Florida Humanities Monographs, 61). publisher-loc, University of Florida Press, 1988. x + 310pp. $30.00. SEÁN HAND SEÁN HAND UNIVERSITY COLLEGE OF WALESABERYSTWYTH Search for other works by this author on: Oxford Academic Google Scholar French Studies, Volume XLIV, Issue 4, October 1990, Pages 490–491, https://doi.org/10.1093/fs/XLIV.4.490 Published: 01 October 1990
B-spline representation of optical surfaces and its accuracy in a ray trace algorithm (2011)

We introduce a representation of aspheric surfaces that is based on a B-spline quasi-interpolation scheme. The scheme is implemented in a ray trace algorithm, and bounds on the approximation error are established. Examples for the reproduction of aspheric surfaces in polynomial description and the ray tracing accuracy are presented. The proposed approach allows the specification of local and global structures and the efficient treatment of measured surface data. The representation gives access to a wavelet analysis, offering extended possibilities for the tolerance analysis of optical systems containing aspheric elements.
Comparative Efficacy of Two Doses of Nebulized Colistimethate for the Eradication of <i>Pseudomonas Aeruginosa</i> in Children with Cystic Fibrosis (2007)

There is no difference in the efficacy between a 30 mg dose and a 75 mg dose of colistimethate for P aeruginosa eradication in children with CF and intermittent colonization.
Role of Troponin I Phosphorylation in Protein Kinase C-mediated Enhanced Contractile Performance of Rat Myocytes (2003)

Our goal was to define the role of phosphorylated cardiac troponin-I in the adult myocyte contractile performance response to activated protein kinase C. In agreement with earlier work, endothelin enhanced both adult rat myocyte contractile performance and cardiac troponin-I phosphorylation. Protein kinase C participated in both responses. The role of cardiac troponin-I phosphorylation in the contractile function response to protein kinase C was further investigated using gene transfer into myocytes of troponin-I isoforms/mutants lacking one or more phosphorylation sites previously identified in purified cardiac troponin-I. Sarcomeric replacement with slow skeletal troponin-I-abrogated protein kinase C-mediated troponin-I phosphorylation. In functional studies, endothelin slowed relaxation in myocytes expressing slow skeletal troponin-I, while the relaxation rate increased in myocytes expressing cardiac troponin-I. Based on these results, acceleration of myocyte relaxation during protein kinase C activation largely depended on cardiac troponin-I phosphorylation. Experiments with troponin-I isoform chimeras provided evidence that phosphorylation sites in the amino portion of cardiac troponin I-mediated the protein kinase C acceleration of relaxation. The cardiac troponin-I Thr-144 phosphorylation site identified in earlier biochemical studies was not significantly phosphorylated during the acute contractile response. Thus, amino-terminal protein kinase C-dependent phosphorylation sites in cardiac troponin-I are likely responsible for the accelerated relaxation observed in adult myocytes.
Grating compensation of third-order fiber dispersion (1992)

Subpicosecond optical pulses propagating in single-mode fibers are severely distorted by third-order dispersion even at the fiber's zero-dispersion wavelength ( lambda /sub 0/). Using cross-correlation techniques, the authors measured the broadening of a 100-fs pulse to more than 5 ps after passing through 400 m of fiber near lambda /sub 0/. The measured asymmetric and oscillatory pulse shape is in agreement with calculations. A grating and telescope apparatus was configured to simultaneously equalize both third- and second-order dispersion for wavelengths slightly longer than lambda /sub 0/. Nearly complete compensation has been demonstrated for fiber lengths of 400 m and 3 km of dispersion-shifted fiber at wavelengths of 1560-1580 nm. For the longer fibers, fourth-order dispersion due to the grating becomes important.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Disruption of the Coxsackievirus and Adenovirus Receptor-Homodimeric Interaction Triggers Lipid Microdomain- and Dynamin-dependent Endocytosis and Lysosomal Targeting (2013)

The coxsackievirus and adenovirus receptor (CAR) serves as a docking factor for some adenovirus (AdV) types and group B coxsackieviruses. Its role in AdV internalization is unclear as studies suggest that its intracellular domain is dispensable for some AdV infection. We previously showed that in motor neurons, AdV induced CAR internalization and co-transport in axons, suggesting that CAR was linked to endocytic and long-range transport machineries. Here, we characterized the mechanisms of CAR endocytosis in neurons and neuronal cells. We found that CAR internalization was lipid microdomain-, actin-, and dynamin-dependent, and subsequently followed by CAR degradation in lysosomes. Moreover, ligands that disrupted the homodimeric CAR interactions in its D1 domains triggered an internalization cascade involving sequences in its intracellular tail.
Subcutaneous concentrations following topical iontophoretic delivery of diclofenac (2012)

A self-contained Wearable Electronic Disposable Drug Delivery (WEDD(®)) patch was used to demonstrate that diclofenac levels delivered by iontophoresis are greater than estimated minimal effective concentrations in local subcutaneous tissue and are also greater than either passive transdermal or intravenous delivery using hairless rats. In vitro iontophoretic delivery was evaluated to optimize donor cell formulation using Franz diffusion cells and 1000 NMWL Millipore ultrafiltration membrane. In vivo animal studies were done using patches powered with a 4-volt system, consisting of a 1-volt Zn anode and Ag/AgCl cathode with built in 3-volt lithium battery. Blood and microdialysis samples were collected at different time points after patch application. Current levels increased to 1.0 mA at 30 min, then fell to a steady state of ~ 0.4 mA. Both WEDD(®) and passive patches produced measurable levels of diclofenac in the subcutaneous tissue below the application site (C(max) ± SE = 113.3 ± 61.7 ng/mL and 36.3 ± 15.9 ng/mL, respectively). The dose delivered in six hours was calculated to be 0.226 ± 0.072 mg and 0.430 ± 0.048 mg in passive and iontophoretic delivery, respectively. Diclofenac was not detected in the subcutaneous tissue after intravenous administration of 1.5 mg/kg diclofenac solution. The trend indicates that WEDD(®) can be used to successfully deliver diclofenac to subcutaneous tissue to concentrations higher when compared to either passive delivery or intravenous dosing of 1.5 mg/kg.
Simplified batch equilibration for D/H determination of non‐exchangeable hydrogen in solid organic material (2009)

Hydrogen isotopic analysis of organic materials has been widely applied in studies of paleoclimate, animal migration, forensics, food and flavor authentication, and the origin and diagenesis of organic matter. Hydrogen bound to carbon (C-H) generally retains isotopic information about the water present during organic matter synthesis and associated biosynthetic fractionations, but hydrogen bound to other elements (O, S, or N) can readily exchange with atmospheric water vapor and reflects recent exposure to water or vapor. These two pools must be separated to obtain meaningful information from isotope ratios of organic materials. Previously published analytical methods either replace exchangeable H chemically or control its isotopic composition, usually by equilibration with water or waters of known isotopic composition. In addition, the fraction of H that is exchangeable can vary among samples and is itself of scientific interest. Here we report an improved and automated double-equilibration approach.Samples are loaded in a 50-position autosampler carousel in an air-tight aluminum equilibration chamber. Water vapor of known isotopic composition is pumped through the chamber at 115 degrees C for at least 6 h. After flushing with dry N(2) and being cooled, the carousel is rapidly transferred from the equilibration chamber to a He-purged autosampler attached to a pyrolysis elemental analyzer connected to an isotope ratio mass spectrometer. By equilibrating two aliquots of each sample with two isotopically distinct waters, it is possible to calculate both (1) the D/H ratio of non-exchangeable H, and (2) the fraction of H that is exchangeable. Relative to previous double-equilibration techniques, this approach offers significant reductions in sample size and labor by allowing simultaneous equilibration of several tens of samples.
<title>Design and performance of the 2-ID-B scanning x-ray microscope</title> (1998)

We have constructed a high resolution scanning x-ray microscopy at the 2-ID-B beamline at the Advanced Photon Source for 1-4 keV x-ray imaging and microspectroscopy experiments. The microscope uses a Fresnel zone plate to focus coherent x-ray undulator radiation to a 150 nm focal spot on a sample. The spectral flux in the focus is 10<SUP>8</SUP> ph/s/0.1 percent BW. X- ray photons transmitted by the sample are detected by an avalanche photodiode as the sample is scanned to form an absorption image. The sample stage has both coarse and fine translation axes for raster scanning and a rotation axis for microtomography experiments. The incident x- ray beam energy can also be scanned and a rotation axis for microtomography experiments. The incident x-ray beam energy can also be scanned via the 2-ID-B monochromator while the sample is kept in focus to record spatially resolved absorption spectra. We have measured the performance of the instrument with various test objects. THe microscope hardware, software, and performance are discussed in this paper.