gebhart/patrepeval huggingface dataset:
Self Hosting vs. Cloud Hosting: Accounting for the Security Impact of Hosting in the Cloud. (2010)

As more and more organizations consider moving their applications and data from dedicated hosting infrastructure, which they own and operate, to shared infrastructure leased from ‘the cloud’, security remains a key sticking point. Tenants of cloud hosting providers have substantially less control over the construction, operation, and auditing of infrastructure they lease than infrastructure they own. Because cloud-hosted infrastructure is shared, attackers can exploit the proximity that comes from becoming a tenant of the same cloud hosting provider. As a result, some have argued that that cloud-hosted infrastructure is inherently less secure than the self-hosted infrastructure, and that it will never be appropriate for high-stakes applications such as health care or financial transaction processing. We strive to present a more balanced treatment of the potential security impacts of transitioning to cloud-hosted infrastructure, surveying both the security costs and security benefits of doing so. The costs include exposure to new threats, some of which are technological, but many others of which are contractual, jurisdictional, and organizational. We also survey potential countermeasures to address these threats, which are also as likely to be contractual or procedural as technological. Transitioning to a cloud-hosted infrastructure may also have security benefits; some security measures have high up-front costs, may become affordable when amortized at cloud scale, and impact threats common to both cloudand self-hosted infrastructures. 1
Activation of TLR4 Is Required for the Synergistic Induction of Dual Oxidase 2 and Dual Oxidase A2 by IFN-γ and Lipopolysaccharide in Human Pancreatic Cancer Cell Lines (2013)

Pancreatitis is associated with release of proinflammatory cytokines and reactive oxygen species and plays an important role in the development of pancreatic cancer. We recently demonstrated that dual oxidase (Duox)2, an NADPH oxidase essential for reactive oxygen species-related, gastrointestinal host defense, is regulated by IFN-γ-mediated Stat1 binding to the Duox2 promoter in pancreatic tumor lines. Because LPS enhances the development and invasiveness of pancreatic cancer in vivo following TLR4-related activation of NF-κB, we examined whether LPS, alone or combined with IFN-γ, regulated Duox2. We found that upregulation of TLR4 by IFN-γ in BxPC-3 and CFPAC-1 pancreatic cancer cells was augmented by LPS, resulting in activation of NF-κB, accumulation of NF-κB (p65) in the nucleus, and increased binding of p65 to the Duox2 promoter. TLR4 silencing with small interfering RNAs, as well as two independent NF-κB inhibitors, attenuated LPS- and IFN-γ-mediated Duox2 upregulation in BxPC-3 cells. Induction of Duox2 expression by IFN-γ and LPS may result from IFN-γ-related activation of Stat1 acting in concert with NF-κB-related upregulation of Duox2. Sustained extracellular accumulation of H(2)O(2) generated by exposure to both LPS and IFN-γ was responsible for an ∼50% decrease in BxPC-3 cell proliferation associated with a G(1) cell cycle block, apoptosis, and DNA damage. We also demonstrated upregulation of Duox expression in vivo in pancreatic cancer xenografts and in patients with chronic pancreatitis. These results suggest that inflammatory cytokines can interact to produce a Duox-dependent pro-oxidant milieu that could increase the pathologic potential of pancreatic inflammation and pancreatic cancer cells.
Abnormal Spontaneous Rosette Formation and Rosette Inhibition in Lung Carcinoma (1975)

Fifty-five children with CID and known ADA status were studies at a workshop held in Albany, New York. Erythrocyte ADA determinations were performed in 22 of the 55 patients, 13 of whom were ADA negative. The ADA defect appears to be transmitted as an autosomal recessive trait. Some patients with CID and ADA deficiency have characteristic radiologic abnormalities of the skeleton, which are not found in other illnesses. The thymus glands of all patients with CID and ADA deficiency who could be examined have evidence of thymic involution manifested by presence of Hassall's corpuscles and differentiated germinal epithelium; this is in contrast to "classic" thymus findings in CID with normal ADA. Adenosine deaminase probably plays an important, although as yet undefined, role in lymphocyte development and/or function. The deficiency of ADA in CID is the first enzyme defect observed in a deficiency disease of specific immunity.
Brillouin Scattering Study of the Volume Phase Transition in Poly-N-Isopropylacrylamide Gels (1995)

Brillouin scattering spectra of poly-N-isopropylacrylamide (NIPA) gels swollen to equilibrium in water were measured as a function of temperature both in the swollen and the shrunken phases. This is the first Brillouin scattering experiment on a gel undergoing a volume phase transition. At the discontinuous volume phase transition occuring at 33.6° C, large changes were observed in both of the Brillouin shift and the spectral width. From the measured spectra and the temperature-dependent refractive index of the gel, the hypersonic velocity and the attenuation were determined as a function of temperature. The results are analyzed in terms of the nature of sound propagation in gels, structure of the shrunken phase, relaxation processes of the network and solvent, and a role played by water molecules at the phase transition.
Study on Location Decisions for Cloud Transportation System Rental Station (2012)

최근 개인차량의 증가로 인해 도로교통의 혼잡은 심화되고 있다. 개인차량의 운행 억제를 위한 여러 방편 중 카쉐어링, 렌트카 등의 시스템이 IT 기술과 접목되어 등장하고 있다. 또한, 차량의 소유를 억제하고 아울러 지속가능한 교통환경을 위한 차량공유 시스템에 대한 도입이 검토되고 있다. 이러한 차량 공유는 도로교통의 혼잡을 줄이고 차량의 효율성을 증대시키며 보다 친환경적인 교통의 구현을 목적으로 한다. 본 논문에서는 차량공유시스템에 대한 개념, 체계도, 운영시나리오 등을 소개하고자 한다. 아울러 차량 공유시스템 운영에 있어 최우선 과제인 차량 대여소 입지선정 및 수요를 추정하였다. 연구지역은 부산시 남구, 해운대구, 수영구를 연구 지역으로 선정하고 인구수, 종사자수, 학생수, OD 통행량 등 주요 교통현황을 분석하고 이용 설문조사를 통해 설정된 존의 수요를 추정하였다. 각 존의 발생통행과 도착통행을 고려하고, 이용 빈도 평균사용시간을 분석해 필요 수요를 산정하였다. 대여소 입지선정은 입지후보지를 인구 밀도와 접근성을 통해 평가하고 평가단위를 통일하기위해 평과결과를 정규화 하여 각 후보지를 평가하였다. 평가점수에 따라 선정된 입지후보지의 CTS 존 수요에 따른 차량 대수 및 주차면수를 산정하였다. 산정결과 대표존으로 해운대구 우1동의 3개의 후보지중 해운대광장공영주차장과 동백사거리공영주차장이 선정되었으며 각각의 차량대수와 주차면은 11대와 14.23면, 7.9대와 10.29면으로 추정되었다. 향후연구로 클라우드 교통 구현시 발생된 실데이터의 적용을 통한 정확한 수요추정이 필요하며 선정된 대여소간의 차량 재분배를 위한 효율적인 네트워크 설계와 알고리즘이 연구되어야 할 것이다. Recently, traffic congestion has become serious due to increase of private car usages. Carsharing or other innovative public transportation systems were developed to alleviate traffic congestion and carbon emissions. These measures can make the traffic environment more comfortable, and efficient. Cloud Transportation System (CTS) is a recent carsharing model. User can rent an electronic vehicles with various traffic information through the CTS. In this study, a concept, vision and scenarios of CTS are introduced. And, authors analyzed the location of CTS rental stations and estimated CTS demands. Firstly, we analyze the number of the population, employees, students and traffic volume in study areas. Secondly, the frequency and utilization time are examined. Demand for CTS in each traffic zone was estimated. Lastly, the CTS rental station location is determined based on the analyzed data of the study areas. Evaluation standard of the determined location includes accessibility and density of population. And, the number of vehicles and that of parking zone at the rental station are estimated. The result suggests that Haewoondae Square parking lot would be assigned 11 vehicles and 14.23 parking spaces and that Dongbac parking lot be assigned 7.9 vehicles and 10.29 parking spaces. Further study requires additional real-time data for CTS to increase accuracy of the demand estimation. And network design would be developed for redistribution of vehicles.
Transforming growth factor-beta1 circulates in normal human plasma and is unchanged in advanced metastatic breast cancer. (1995)

A method has been developed to determine true plasma transforming growth factor beta (TGF-beta) levels by using the platelet alpha granule-specific marker, platelet factor 4, to correct for the TGF-beta contributed by platelets degranulated ex vivo. TGF-beta levels were measured on acid-ethanol extracts of human plasma using isoform-specific sandwich enzyme-linked immunosorbent assays. Normal human subjects had 4.1 +/- 2.0 ng/ml TGF-beta1 (range, 2.0-12.0; n = 42), <0.2 ng/ml TGF-beta2, and <0.1 ng/ml TGF-beta3 in their plasma. There were no significant changes with age or with hormonal status, but any given individual showed fluctuations of up to 3-fold in measured plasma TGF-beta levels due to unknown factors. Of 28 patients with advanced metastatic breast cancer, 2 had greatly elevated TGF-beta1 levels, while the rest were in the normal range. The presence of physiologically significant levels of TGF-beta1 in the plasmas of normal human subjects may indicate previously unsuspected endocrine roles for this peptide, while TGF-beta2 and TGF-beta3 appear to act only in a local autocrine/paracrine fashion.
Utilising gelatin: some applications in the coatings, adhesives and allied industries (1983)

Various reviews have appeared in earlier years dealing with several aspects of gelatin. Articles have also appeared dealing with the structure of the material and its properties, and with its properties in the solid state. Specifications for the purer form of gelatin have appeared in a number of Pharmacopiea, and commercial specification covering several qualities of the material have also been published.
Critical energy criterion for the shock initiation of explosives by projectile impact (1988)

Abstract The critical energy (Ec) criterion developed by Walker and Wasley for predicting the response of bare, heterogeneous explosives to flying‐plate impact, is modified for application to flat‐nosed rods and spherical projectiles. This modification redefines the shock duration term used in calculating Ec and implies that a minimum volume of explosive at a given shock energy is needed before initiation occurs. The modification also changes the L/D ratio of the projectile at which plate behaviour changes to rod behaviour from the currently accepted value of approximately 1/4 to 1/12. Comparisons between the modified criterion and published experimental data show that the same value of Ec can now be obtained from both flying‐plate and more complex projectile impacts into the same explosive.
Synthesis and Thermoelectric Power of Nitrogen-Doped Carbon Nanotubes (2003)

We have previously shown that high-purity multiwalled carbon nanotubes (pristine MWNTs) can be prepared from a mixture of xylene-ferrocene (99 at% C:1 at% Fe) inside a quartz tube reactor operating at approximately 700 degrees C. In a similar process, approximately 3 g of melamine (C3H6N6) was introduced during the growth of MWNTs to prepare nitrogen-doped nanotubes. The structural and electronic properties of nitrogen-doped MWNTs were determined by scanning electron microscopy, high-resolution transmission electron microscopy (HRTEM), electron energy loss spectroscopy (EELS), and thermopower measurements. The individual nitrogen-doped nanotube exhibits a bamboo-like structure and comprises 6-16 tube walls, as evidenced by HRTEM studies. The EELS measurements yielded an average nitrogen content of approximately 5 at% in the doped tubes. The thermoelectric power data of nitrogen-doped MWNTs remained negative even after exposure to oxygen for an extended period of time, suggesting that nitrogen doping of MWNTs renders them n-type, consistent with scanning tunneling spectroscopic studies on similar nanotubes.
A HAL for Component-Based Embedded Operating Systems (2006)

Many standards for operating system interfaces or on-chip bus interfaces have been developed. Component-based EOS projects are seeking approaches to adapt component based software development technologies to embedded systems. An important issue is to develop hardware independent software that meets differing requirements pertinent to embedded applications. The hardware abstraction layer (HAL) presented here is to serve this purpose. In JBEOS, a component based EOS developed at Peking Univ. The following aspects are stressed: abstraction of basic data types, including their in-memory representation and operations; encapsulation of H/W dependent features into clear interfaces for kernel and user applications; H/W peculiarities should be encapsulated but not masked, i.e., HAL should provide mechanisms to access H/W directly when desired; minimized ROM and RAM footprints; supports for EOS above with no bias to any specific design and/or implementation; minimum efforts required when porting to a new platform.
MRI of the Postoperative Spine (1990)

ROSS, JEFFREY S. M.D.; MODIC, MICHAEL T. M.D.; MASARYK, THOMAS J. M.D. Author Information
Toward An Ideal 3-D Cad System (1987)

A shared representation is crucial to effective, natural man-machine interaction. Unfortunately, little is known about peoples mental representation of shape; this prevents construction of truly effective computer-supported 3-D design media. How do people represent shape? We observe that design is typically an iterative process, starting with sketching and proceeding through detailing. Thus several different representations are required to support the design process. We investigate peoples naive, preattentive representation of shape to understand what sort of representation would best support the initial sketching stage of design. We then use our conclusions to build and evaluate a multi-representation 3-D CAD tool, and demonstrate enhanced performance.
Nanometer-scale Fluorescence Resonance Optical Waveguides (2004)

The telecommunications revolution has created a strong motivation to build photonic devices of ever smaller size and higher density. Using photosynthetic structures found in nature as an inspiration, we synthesized artificial structures that act like diffusive waveguides. These waveguides use FRET to transport energy, and we demonstrated the idea with 3- and 5-fluorophore structures which utilize DNA as a scaffold. A quantitative model that explains the results and provides the mechanism behind the energy transfer is also presented.
Protein Misfolding and Aggregation in Alzheimer’s Disease and Type 2 Diabetes Mellitus (2014)

In general, proteins can only execute their various biological functions when they are appropriately folded. Their amino acid sequence encodes the relevant information required for correct three-dimensional folding, with or without the assistance of chaperones. The challenge associated with understanding protein folding is currently one of the most important aspects of the biological sciences. Misfolded protein intermediates form large polymers of unwanted aggregates and are involved in the pathogenesis of many human diseases, including Alzheimer's disease (AD) and Type 2 diabetes mellitus (T2DM). AD is one of the most prevalent neurological disorders and has worldwide impact; whereas T2DM is considered a metabolic disease that detrementally influences numerous organs, afflicts some 8% of the adult population, and shares many risk factors with AD. Research data indicates that there is a widespread conformational change in the proteins involved in AD and T2DM that form β-sheet like motifs. Although conformation of these β-sheets is common to many functional proteins, the transition from α-helix to β-sheet is a typical characteristic of amyloid deposits. Any abnormality in this transition results in protein aggregation and generation of insoluble fibrils. The abnormal and toxic proteins can interact with other native proteins and consequently catalyze their transition into the toxic state. Both AD and T2DM are prevalent in the aged population. AD is characterized by the accumulation of amyloid-β (Aβ) in brain, while T2DM is characterized by the deposition of islet amyloid polypeptide (IAPP, also known as amylin) within beta-cells of the pancreas. T2DM increases pathological angiogenesis and immature vascularisation. This also leads to chronic cerebral hypoperfusion, which results in dysfunction and degeneration of neuroglial cells. With an abundance of common mechanisms underpinning both disorders, a significant question that can be posed is whether T2DM leads to AD in aged individuals and the associations between other protein misfolding diseases.
Restricted, canonical, stereotyped and convergent immunoglobulin responses (2015)

It is becoming evident that B-cell responses to particular epitopes or in particular contexts can be highly convergent at the molecular level. That is, depending on the epitope targeted, persons of diverse genetic backgrounds and immunological histories can use highly similar, stereotyped B-cell receptors (BCRs) for a particular response. In some cases, multiple people with immunity to a particular epitope or with a type of B-cell neoplasia will elicit antibodies encoded by essentially identical immunoglobulin gene rearrangements. In other cases, particular VH genes encode antibodies important for immunity against pathogens such as influenza and HIV. It appears that the conserved antibody structures driving these stereotyped responses are highly limited and selected. There are interesting and important convergences in the types of stereotyped BCRs induced in conditions of immunity and B-cell-related pathology such as cancer and autoimmunity. By characterizing and understanding stereotyped B-cell responses, novel approaches to B-cell immunity and in understanding the underlying causes of B-cell pathology may be discovered. In this paper, we will review stereotyped BCR responses in various contexts of B-cell immunity and pathology.
Face2Emoji (2017)

One way to indicate nonverbal cues is by sending emoji (e.g., 😂), which requires users to make a selection from large lists. Given the growing number of emojis, this can incur user frustration, and instead we propose Face2Emoji, where we use a user's facial emotional expression to filter out the relevant set of emoji by emotion category. To validate our method, we crowdsourced 15,155 emoji to emotion labels across 308 website visitors, and found that our 202 tested emojis can indeed be classified into seven basic (including Neutral) emotion categories. To recognize facial emotional expressions, we use deep convolutional neural networks, where early experiments show an overall accuracy of 65% on the FER-2013 dataset. We discuss our future research on Face2Emoji, addressing how to improve our model performance, what type of usability test to run with users, and what measures best capture the usefulness and playfulness of our system.
ECG for blind identity verification in distributed systems (2011)

This paper discusses ECG biometric recognition in a distributed system, such as smart cards. In a setting where every card is equipped with an ECG sensor to record heart beats from the fingers, and to subsequently perform identity verification, the interest is in protecting the card holder from a set of unknown/unseen biometric traits. Prior works have examined ECG biometrics in settings where a particular subject was to be identified among a set of enrollees. However, this treatment limits the applicability of this biometric. The Autocorrelation - Linear Discriminant Analysis (AC/LDA) is revisited, to propose a strategic extension of the methodology, in order to account for recognition among unknown individuals (blind verification). The discriminant is trained individually for every smart card, on the samples of the subject to be enrolled, as well as a generic dataset of ECG recordings. This enables the recognizer to protect the template against attacks by biometric samples that have not been used to train the discriminant. In addition, we present a methodology for the selection of the matching threshold, which targets to control false acceptance while being experimentally optimized for a particular smart card.
Gaucher disease gene<i>GBA</i>functions in immune regulation (2012)

Inherited deficiency of acid β-glucosidase (GCase) due to biallelic mutations in the GBA (glucosidase, β, acid) gene causes the classic manifestations of Gaucher disease (GD) involving the viscera, the skeleton, and the lungs. Clinical observations point to immune defects in GD beyond the accumulation of activated macrophages engorged with lysosomal glucosylceramide. Here, we show a plethora of immune cell aberrations in mice in which the GBA gene is deleted conditionally in hematopoietic stem cells (HSCs). The thymus exhibited the earliest and most striking alterations reminiscent of impaired T-cell maturation, aberrant B-cell recruitment, enhanced antigen presentation, and impaired egress of mature thymocytes. These changes correlated strongly with disease severity. In contrast to the profound defects in the thymus, there were only limited cellular defects in peripheral lymphoid organs, mainly restricted to mice with severe disease. The cellular changes in GCase deficiency were accompanied by elevated T-helper (Th)1 and Th2 cytokines that also tracked with disease severity. Finally, the proliferation of GCase-deficient HSCs was inhibited significantly by both GL1 and Lyso-GL1, suggesting that the "supply" of early thymic progenitors from bone marrow may, in fact, be reduced in GBA deficiency. The results not only point to a fundamental role for GBA in immune regulation but also suggest that GBA mutations in GD may cause widespread immune dysregulation through the accumulation of substrates.
Morphological Changes in the Peritoneal Vasculature of Patients on CAPD with Ultrafiltration Failure (1996)

Vascular changes in the peritoneum were histochemically assessed in patients on continuous ambulatory peritoneal dialysis (CAPD) with ultrafiltration failure. Light microscopy showed extensive interstitial fibrosis, mesothelial denudation and vascular changes. Morphological changes in the vasculature were observed at different levels. The specific changes in the vasculature in these patients were characterized by severe fibrosis and hyalinization of the media of venules. Immunofluorescence microscopy revealed extensive deposition of such extracellular matrices as type IV collagen and laminin in the vascular wall. Electron microscopy revealed a significant increase in collagenous fibers and degeneration of smooth muscle cells in the media. However, the endothelial cells at the levels of vasculature affected were relatively well preserved. These pathological alterations in the vasculature in CAPD patients with ultrafiltration failure suggest that certain toxic factors, such as a high osmolar dialysate or low pH of dialysate, had affected the peritoneal vasculature from the adventitial side rather than the endothelial side. These vascular changes in the peritoneum are thought to be irreversible, associated with deterioration of peritoneal function, and to cause ultrafiltration failure in the patients on long-term CAPD therapy.
Motor Cortex Stimulation for Central and Neuropathic Facial Pain: A Prospective Study of 10 Patients and Observations of Enhanced Sensory and Motor Function during Stimulation (2005)

These results provide further support for the use of motor cortex stimulation in facial neuropathic pain and document pain improvement as measured by multidimensional scales. Observations of motor and sensory improvements during stimulation suggest that stimulation alters cortical plasticity and inhibits thalamic hyperactivity.