gebhart/patrepeval huggingface dataset:
Learning Articulated Motions From Visual Demonstration (2014)

Many functional elements of human homes and workplaces consist of rigid components which are connected through one or more sliding or rotating linkages. Examples include doors and drawers of cabinets and appliances; laptops; and swivel office chairs. A robotic mobile manipulator would benefit from the ability to acquire kinematic models of such objects from observation. This paper describes a method by which a robot can acquire an object model by capturing depth imagery of the object as a human moves it through its range of motion. We envision that in future, a machine newly introduced to an environment could be shown by its human user the articulated objects particular to that environment, inferring from these "visual demonstrations" enough information to actuate each object independently of the user.
El papel de la UTP en el diagnóstico de la Fibra de Vidrio (2008)

El Ministerio de Educacion (MEDUCA) tomo la decision de remover el aislante de fibra de vidrio en los planteles educativos del pais, principalmente por razones de su deterioro. Este material habia sido instalado varios anos atras y algunos presentaban danos, por lo que era necesario reemplazarlo. Al realizar esta actividad, se presentaron diversos sintomas en los estudiantes, docentes, padres de familia y trabajadores manuales de estos planteles.
Physical characterization and rheological behavior of polyurethane/poly(ϵ‐caprolactone) blends, prepared by solution blending using dimethylacetamide (2012)

Abstract Blending effects of thermoplastic polyurethane based on polycaprolactone diol, PU (PCL diol), and poly (ϵ‐caprolactone) (PCL) on the rheological properties and morphological behavior of the solvent‐cast blends were investigated by parallel plate rheometer. The amount of PCL was varied from 20 to 50% by weight. Fourier transform infrared (FTIR) results showed existence of hydrogen bonding in PU/PCL blends. From FTIR, we also found the increase of PCL composition tends to reduction of intermolecular hydrogen bonding and enhancing of microphase separation in blends. Differential scanning calorimetry (DSC) indicated that these blend systems are partially miscible. Based on rheological characterization, decrease can be seen in the moduli, zero shear viscosity and plateau modulus of blends, as compared with net PU. Using Cole‐Cole plots and composition dependencies of η 0 and the other viscoelastic functions expressed variation of morphology of blends due to increase of PCL content. Frequency sweep tests on PU/PCL (80/20) at five temperatures showed validity of time‐temperature superposition in this blend. © 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
A Phenomenological Combustion Model for Common Rail Multi-Jet Diesel Engine (2004)

The simplest way to describe the combustion process into the cylinder of an internal combustion engine and the associated heat release is to estimate at each crankshaft angular position the mass fraction of fuel burned using a proper function. There is a number of functions recorded in the literature that have been used for this purpose, the most relevant being likely the so-called Wiebe function. These functions have been developed both for spark ignition and diesel engines. The development of modern Common Rail injection systems makes the application of this kind of methodology particularly challenging. The trend seems to indicate, in fact, that in the near future Diesel engine injection systems will perform up to five injections per engine cycle. Therefore the way energy is released into the cylinder could become very complex to be described and the simple approaches developed up to now could be not sufficient anymore. This paper deals with the development of a single zone combustion model able to correctly describe the heat release rate for a common rail multi-jet diesel engine employing up to 4 injections per engine cycle. The model has been developed step-by-step from the simplest case of a single injection to the more complex one with 4 injections. It has been identified and validated using experimental data obtained employing from 1 to 4 different injections. Premixed and diffusive combustions have been taken into account, both modelled as “Wiebe functions”. Particular identification problems (such as modelling error with multiple injection or identification robustness procedure) are approached on the basis of real data. The main result is that increasing the number of injections actuated (and then the combustion phases) predictive properties of the model are still acceptable, and identification procedure is robust if initial values of unknown parameters are properly set. The obtained results allowed observing for example the way the combustion delays (i.e the time delays between each Start of Injection and the corresponding Start of Combustion) are modified as the number of injections increases, as well as other important combustion characteristics.
Thermal [1,j] sigmatropic rearrangements (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThermal [1,j] sigmatropic rearrangementsCharles W. SpanglerCite this: Chem. Rev. 1976, 76, 2, 187–217Publication Date (Print):April 1, 1976Publication History Published online1 May 2002Published inissue 1 April 1976https://pubs.acs.org/doi/10.1021/cr60300a002https://doi.org/10.1021/cr60300a002research-articleACS PublicationsRequest reuse permissionsArticle Views1546Altmetric-Citations257LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Plasminogen activators promote excitotoxicity‐induced retinal damage (2005)

Increased levels of extracellular l-glutamate have been suggested to play a role in retinal damage in a number of blinding diseases such as glaucoma and diabetic retinopathy. Although glutamate can cause retinal damage in part by hyperstimulating its receptors ("excitotoxicity"), the downstream events that lead to retinal damage are poorly understood. In this study, we injected kainic acid (KA), a glutamate receptor agonist that specifically hyperstimulates non-NMDA-type receptors, into the vitreous humor of CD-1 mice and have investigated the role of plasminogen activators (PAs) [tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA)] in excitotoxicity-induced retinal damage. Injection of KA into the vitreous humor led to an up-regulation in tPA and an induction in uPA activity in the retina and this was associated with activation of zymogen plasminogen to active plasmin. Immunocytochemical analysis indicated that retinal ganglion cells (RGCs), constitutively express tPA and release it into the extracellular space upon KA injection. Immunocytochemical analysis also indicated an increase in uPA in the nerve fiber layer after KA injection that was absent in the control retinas. These events were associated with apoptotic death of cells initially in the ganglion cell layer and subsequently in the inner and outer nuclear layer, associated with loss of RGCs and amacrine cells. These phenomena were inhibited when recombinant plasminogen activator inhibitor (rPAI-1) or tPA-STOP were injected into the vitreous humor with KA, whereas a plasmin inhibitor, alpha-2-antiplasmin, failed to attenuate KA-induced retinal damage. Taken together, these results suggest that inhibition of plasminogen activators might attenuate retinal damage in blinding retinal diseases in which hyperstimulation of glutamate receptors is implicated as a causative factor to retinal damage.
Nuclear Translocation of Angiogenic Proteins in Endothelial Cells: An Essential Step in Angiogenesis (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNuclear Translocation of Angiogenic Proteins in Endothelial Cells: An Essential Step in AngiogenesisJunona Moroianu and James F. RiordanCite this: Biochemistry 1994, 33, 42, 12535–12539Publication Date (Print):October 1, 1994Publication History Published online1 May 2002Published inissue 1 October 1994https://pubs.acs.org/doi/10.1021/bi00208a001https://doi.org/10.1021/bi00208a001research-articleACS PublicationsRequest reuse permissionsArticle Views104Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Adrenomedullin in Heart Failure: Pathophysiology and Therapeutic Application (2018)

Adrenomedullin (ADM) is a peptide hormone first discovered in 1993 in pheochromocytoma. It is synthesized by endothelial and vascular smooth muscle cells and diffuses freely between blood and interstitium. Excretion of ADM is stimulated by volume overload to maintain endothelial barrier function. Disruption of the ADM system therefore results in vascular leakage and systemic and pulmonary oedema. In addition, ADM inhibits the renin-angiotensin-aldosterone system. ADM is strongly elevated in patients with sepsis and in patients with acute heart failure. Since hallmarks of both conditions are vascular leakage and tissue oedema, we hypothesize that ADM plays a compensatory role and may exert protective properties against fluid overload and tissue congestion. Recently, a new immunoassay that specifically measures the biologically active ADM (bio-ADM) has been developed, and might become a biomarker for tissue congestion. As a consequence, measurement of bio-ADM might potentially be used to guide diuretic therapy in patients with heart failure. In addition, ADM might be used to guide treatment of (pulmonary) oedema or even become a target for therapy. Adrecizumab is a humanized, monoclonal, non-neutralizing ADM-binding antibody with a half-life of 15 days. Adrecizumab binds at the N-terminal epitope of ADM, leaving the C-terminal side intact to bind to its receptor. Due to its high molecular weight, the antibody adrecizumab cannot cross the endothelial barrier and consequently remains in the circulation. The observation that adrecizumab increases plasma concentrations of ADM indicates that ADM-binding by adrecizumab is able to drain ADM from the interstitium into the circulation. We therefore hypothesize that administration of adrecizumab improves vascular integrity, leading to improvement of tissue congestion and thereby may improve clinical outcomes in patients with acute decompensated heart failure. A phase II study with adrecizumab in patients with sepsis is ongoing and a phase II study on the effects of adrecizumab in patients with acute decompensated heart failure with elevated ADM is currently in preparation.
Space and Status (2005)

This chapter contains section titled: The Social Construction of Space Spatial Institutions Space, Knowledge, and Secrecy
The effect of substituting phosphotyrosine for sulphotyrosine on the activity of hirudin (1990)

Recombinant hirudin (hirudin), which lacks the sulphate group of Typ‐63, has a tenfold‐reduced affinity for α‐thrombin. Incubation of recombinant hirudin with [γ‐ 32 P]ATP and protein tyrosine kinase III from spleen resulted in incorporation of radioactivity into the protein. Phosphatohirudin was purified to homogeneity (overall yield 5%) and shown to contain 1 mol phosphate/mol protein, as a phosphotyrosyl residue at position 63. The kinetics of the inhibition of human α‐thrombin by phosphatohirudin were determined. It was found that the introduction of the negatively charged phosphate had fully restored the affinity of recombinant hirudin for α‐thrombin to the level of the wild‐type sulphatohirudin. The inhibition constant of phosphatohirudin was 18 fM compared with 20 fM for that of sulphatohirudin. Moreover, the values for the on‐and off‐rate constants of the both forms of hirudin were indistinguishable.
A novel and sensitive method for the quantification of <i>N</i> ‐3‐oxoacyl homoserine lactones using gas chromatography–mass spectrometry: application to a model bacterial biofilm (2000)

A method is reported for the quantification of 3-oxoacyl homoserine lactones (3-oxo AHLs), a major class of quorum-sensing signals found in Gram-negative bacteria. It is based on the conversion of 3-oxo AHLs to their pentafluorobenzyloxime derivatives followed by gas chromatography-mass spectrometry (electron capture-negative ion). The method used [13C16]-N-3-oxo-dodecanoyl homoserine lactone ([13C16]-OdDHL) as the internal standard, and its validity was tested by spiking the supernatant and cell fractions with three levels of 3-oxo AHLs, i.e. 1, 10 and 100 ng per sample. These showed the method to be both sensitive (S/N ratio >10:1 for 1 ng) and accurate. The assay was applied to the biofilm and effluent of a green fluorescent protein (GFP)-expressing strain of Pseudomonas aeruginosa (6294) culture grown in flow cells. Biofilm volume was determined for three replicate flow cells by confocal scanning laser microscopy. OdDHL was detected in the biofilm at 632 +/- 381 microM and the effluent at 14 +/- 3 nM. The biofilm concentration is the highest level so far reported for an AHL in a wild-type bacterial system. The next most abundant 3-oxo AHL in the biofilm and effluent was N-3-oxo-tetradecanoyl homoserine lactone (OtDHL) at 40 +/- 15 microM and 1.5 +/- 0.7 nM respectively. OtDHL is unreported for P. aeruginosa and has an activity equivalent to OdDHL in a lasR bioassay. Two other 3-oxo AHLs were detected at lower concentrations: N3-oxo-decanoyl homoserine lactone (ODHL) in the biofilm (3 +/- 2 microM) and effluent (1 +/- 0.1 nM); and N-3-oxo-octanoyl homoserine lactone (OOHL) in the effluent (0.1 +/- 0.1 nM).
<title>Guardian substrate as an optical medium for security devices</title> (2000)

Guardian substrate is a coated polymer film that has demonstrated its suitability as a substrate for variety of printed security documents. Guardian consists of a transparent flexible polymer core layer that is coated on both sides with an opacifying coating that can be printed on using conventional printing techniques. Probably the most evolutionary feature of this substrate architecture is that is provides the facility to create areas on a document that are either transparent or semi-transparent, depending on how the coating is applied. Now for the first time documents can be secured using devices that rely on transmission through a medium with high optical clarity. Guardian substrate provides the flexibility of varying the degree of opacity to suit the device being employed. This paper discusses the benefits of this important capability, using a number of new and adapted devices to demonstrate the potential of this new platform.
Some Novel Reactions of Benzoxazole Derivatives with Dimethyl Acetylenedicarboxylate (1980)

Benzoxazole derivativesll) and dimethyl acetylenedicarboxylate(DM?iD) gave novel tricyclic compound(^) through the [2+41 cycloaddition of 1 and DMAD together with a solvent addition product(4) and a ring-opened compound(?) in alcoholic solvent at room temperature.
Tradeoffs in bacteriophage life histories (2014)

Viruses are the most abundant biological entities on the planet, yet most classical principles of evolutionary biology and ecology were not developed with viruses in mind. Here, the concept of biological tradeoffs, a fundamental tenet of life history theory, is examined in the context of bacteriophage biology. Specifically, several important parameters of phage life histories-replication, persistence, host range, and adsorption-are evaluated for tradeoffs. Available data indicate that replication rate is strongly negatively correlated with both persistence and host range, suggesting that the well-documented tradeoff in macroorganisms between offspring production and offspring quality also applies to phages. The biological tradeoffs that appear to characterize viruses' life histories have potential importance for viral evolution, ecology, and pathogenesis.
Making Garbage Collection Wear Conscious for Flash SSD (2012)

Since NAND flash memory has certain inherent limitations like out-of-place updates and a coarse granularity of erase unit, a NAND flash memory based solid state disk needs a garbage collector to erase and recycle previously used blocks from time to time. Garbage collection, however, can significantly decrease flash SSD performance as it incurs high overhead. Various techniques have been proposed to reduce the cost of garbage collection. Unfortunately, most of them only take performance into consideration while ignoring block wear status when choosing victim blocks. As a result, some blocks could be frequently erased and recycled due to garbage collection, and thus, prematurely fail because of a high concentration of erasure cycles. In this research, we propose a wear conscious garbage collection mechanism named WECO (wear conscious). To demonstrate the effectiveness of WECO, we extend a well-known SSD simulator FlashSim so that WECO can be integrated into typical FTLs (flash translation layers) such as DFTL (demand-based FTL) and PM (page mapping). Experimental results show that WECO-DFTL and WECO-PM substantially improve wear-leveling while maintaining a performance similar to the two original FTLs.
VGF Metabolic-related Gene (2007)

The vgf gene has been shown to be involved in several metabolic pathways. Because the pancreas is crucial to metabolism and food intake, we studied the VGF peptides in bovine, rat, and pig Langherans islets using antisera raised against specific sites along the primary sequence of the rat/mouse and human VGF protein precursor. Whereas almost all of the pancreatic endocrine cells expressed vgf mRNA, when using the VGF antisera a different staining pattern became apparent. VGF(556-565) and VGF(282-291) immunoreactivity were exclusively found in delta somatostatin-producing cells, whereas the human C-terminus antiserum selectively immunolabeled alpha glucagon and pancreatic polypeptide cells. The same cells were decorated with the VGF(443-588) antiserum, which also weakly labeled beta insulin-secreting cells. Finally, the VGF(298-306) peptide and the rat C terminus were found in virtually all pancreatic endocrine cells. Using bovine, swine, and rat pancreatic extracts, data from chromatography and ELISA assay showed the presence of a high molecular mass form compatible with the proVGF and lower molecular mass fractions corresponding to short VGF peptides. In conclusion, selective VGF distribution may suggest a multifaceted cell type-specific processing of proVGF, resulting in different peptides probably involved in neuroendocrine regulatory metabolic mechanisms.
Improving Alzheimer's disease-related cognitive deficits with sigma1 receptor agonists (2002)

Treating dementia of the Alzheimer's type is a terrible challenge that will require an innovative pharmacological strategy simultaneously addressing symptoms and causes of the complex neurodegenerative process involved in Alzheimer's disease. The present review will outline the most recent data, albeit restricted to preliminary preclinical studies, suggesting that the sigma(1) receptor agonist may present some efficacy. The sigma(1) receptor is a unique intraneuronal protein that modulates intracellular Ca(2+) mobilization and extracellular Ca(2+) influx, leading to a wide spectrum of neuromodulatory activity. At the behavioral level, sigma(1)-receptor agonists are antiamnesic and anti-depressant drugs. The sigma(1) receptor is also one of the receptors at which neurosteroids act to exert their rapid nongenomic effects in the brain. In particular, dehydroepiandrosterone (DHEA) is an endogenous sigma(1) agonist and progesterone, a potent antagonist of the sigma(1) receptor. The beta-amyloid protein-related toxicity induces important disturbances of neurosteroid syntheses and releases mechanisms, particularly by affecting the corticotropin-releasing hormone systems. In turn, sigma(1)-receptor agonists showed an enhanced efficacy in animal models of Alzheimer's disease-related learning impairments or depressive responses. In addition, selective sigma(1) agonists, as well as DHEA, showed marked neuroprotective activity in vitro against oxidative stress-related damages. Acting chronically through the sigma(1) receptor may indeed offer a new way to alleviate the cognitive disturbances observed in Alzheimer's disease and promote long-term improvements. (c) 2002 Prous Science. All rights reserved.
Gene expression levels of CSNK1A1 and AAC-11, but not NME1, in tumor tissues as prognostic factors in NSCLC patients. (2010)

This retrospective study indicates that CSNK2A1 and AAC-11, especially in combination, are useful prognosis markers in NSCLC patients after complete resection, independent of lymph node metastasis status.
Induced Smectic Mesomorphism in Mixtures of<i>p</i>-Cyano-<i>p</i>'-pentylbiphenyl and<i>p</i>-Pentylbenzoic Acid (1979)

Abstract The phase diagram of p-cyano-p'-pentylbiphenyl (CPB) and p-pentylbenzoic acid (5BA) shows a maximum value of the nematic-isotropic transition temperature at ∼equimolar concentrations of CPB and the dimer of 5BA (D5BA). Two eutectic points occur at concentrations of D5BA of 8 and 65 mole %, respectively, and an induced smectic phase occurs in the concentration range of 15 to 65 % D5BA. Dielectric properties and the spontaneous homeotropy of some of the mixtures can best be understood by considering the phases to consist primarily of D5BA and CPB, with a small amount of free 5BA modulating the dielectric properties and promoting homeotropic alignment.
Comparison of the pyrogen tests in rabbits and with limulus lysate. (1977)

In the past years an assortment of samples of plasma proteins, enzymes, vaccines and blood substitutes were tested comparatively in rabbits (pyrogen test, European Pharmacopoeia) and with the LAL test (Pyrogent, Byk-Mallinckrodt, Inc.). Specificity and sensitivity were tested with endotoxins and lipid A of gram-negative bacteria. The limulus amebocyte lysate (LAL) test gave similar results or was tenfold more sensitive than the assay in rabbits. More than 300 samples of drugs were examined by both tests. All preparations positive in the rabbit test were positive in the LAL test too. In the testing of plasma proteins the LAL test was more sensitive. The examination of 45 samples of vaccines for pyrogens gave the same result in both assays. Streptokinase does not inhibit the LAL test unspecifically. The LAL test is not an alternative but an additional method in the detection of lipopolysaccharides in drugs.