gebhart/patrepeval huggingface dataset:
Facial Warming Increases the Threshold for Shivering (1999)

A decrease of 1-2 degrees C core temperature provides protection against cerebral ischemia. However, shivering usually prevents reduction in core temperature in unanesthetized patients. Therefore, it was tested whether facial and airway heating increases the shivering threshold and enables core cooling in unanesthetized patients. Nine trials were performed on seven healthy male volunteers. Each subject was positioned supine on a circulating-water mattress (8-15 degrees C) with a convective-air coverlet (15-18 degrees C) extending from the neck to the feet. A dynamic study protocol governed by individualized physiological responses was used. Focal facial (and airway) warming was employed to suppress involuntary motor activity (muscle tensing, shivering) and, thereby, enabling noninvasive cooling to lower the core temperature. The following parameters were monitored: 1) heart rate, 2) blood pressure, 3) core temperature (tympanic, axilla, and rectal), 4) cutaneous temperatures, and 5) a subjective shiver index (scale 1-10). In three, electromyograms and infrared thermographs were also obtained. Upon cooling without facial and airway warming, involuntary motor activity increased until it was widespread. This vigorous motor activity prevented any significant lowering of core temperature or caused it to slightly increase. Subsequently, in all subjects, within seconds after the application of facial focal warming, motor activity was suppressed almost completely, and within minutes core temperatures significantly decreased. Preliminary studies described here indicate that focal facial warming applied during active whole body cooling to initiate mild hypothermia might minimize the need to pharmacologically suppress involuntary motor activity. Such a procedure might be useful for initiating as soon as possible (such as during emergency transport), cerebral mild hypothermia in order to maximize protection and thus improve outcome in neurologically injured patients (head trauma, stroke).
Reaction of phosphenium ions with 1,3-dienes: a rapid synthesis of phosphorus-containing five-membered rings (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReaction of phosphenium ions with 1,3-dienes: a rapid synthesis of phosphorus-containing five-membered ringsA. H. Cowley, R. A. Kemp, J. G. Lasch, N. C. Norman, and C. A. StewartCite this: J. Am. Chem. Soc. 1983, 105, 25, 7444–7445Publication Date (Print):November 1, 1983Publication History Published online1 May 2002Published inissue 1 November 1983https://pubs.acs.org/doi/10.1021/ja00363a040https://doi.org/10.1021/ja00363a040research-articleACS PublicationsRequest reuse permissionsArticle Views265Altmetric-Citations39LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Methylamidation for Sialoglycomics by MALDI-MS: A Facile Derivatization Strategy for Both α2,3- and α2,6-Linked Sialic Acids (2010)

Neutralization of carboxylic acid is an important means to avoid sialic acid dissociation when sialylated glycans are analyzed by matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS). In this paper, we describe a simple and rapid method to modify the sialic acids of sialylated glycans in the presence of methylamine and (7-azabenzotriazol-1-yloxy) trispyrrolidinophosphonium hexafluorophosphate (PyAOP). After methylamidation, sialylated glycans can be analyzed by MALDI-MS without loss of the sialic acid moiety. The electrospray ionization mass spectrometry (ESI-MS) and MALDI-MS analysis of both 3'- and 6'-sialyllactose derivatives indicated that the quantitative conversion of sialic acids was achieved, regardless of their linkage types. This derivatization strategy was further validated with the N-glycans released from three standard glycoproteins (fetuin, human acid glycoprotein, and bovine acid glycoprotein) containing different types of complex glycans. Most importantly, this derivatization method enabled the successful characterization of N-glycans of sera from different species (human, mouse, and rat) by MALDI-MS. Because of the mild reaction conditions, the modification in sialic acid residues can be retained. This improvement makes it possible to detect sialylated glycans containing O-acetylated sialic acid moieties using MALDI-MS in positive-ion mode.
Internet of Things and LoRa™ low-power wide-area networks challenges (2017)

Nowadays there is a lot of effort on the study, analysis and finding of new solutions related to high density sensor networks used as part of the IoT (Internet of Things) concept. LoRa (Long Range) is a modulation technique that enables the long-range transfer of information with a low transfer rate. This paper presents a review of the challenges and the obstacles of IoT concept with emphasis on the LoRa technology. A LoRaWAN network (Long Range Network Protocol) is of the Low Power Wide Area Network (LPWAN) type and encompasses battery powered devices that ensure bidirectional communication. The main contribution of the paper is the evaluation of the LoRa technology considering the requirements of IoT. In conclusion LoRa can be considered a suitable candidate in addressing the IoT challenges.
Near-edge x-ray absorption fine structure study of bonding modifications in BN thin films by ion implantation (1996)

Near-edge x-ray absorption fine structure (NEXAFS) has been used to study the defect content and the bonding modifications induced in BN thin films by ion implantation. The initial films were hexagonal-like BN grown on Si(100) by pulsed laser deposition. Subsequent ion implantation with N2+ at 180 keV induces the formation of a significant proportion of sp3 bonding (cubic-like), and the formation of nitrogen void defects in the remaining sp2 BN. These modifications in the bonding of a film lacking long range order can only be distinguished with a local order technique like NEXAFS.
Utility of a Luminex-based assay for multiplexed, rapid species identification of <i>Candida</i> isolates from an ongoing candidemia surveillance (2010)

A Candida-specific Luminex-based assay with 11 probes was employed for multiplexed, rapid identification of 1182 Candida sp. isolates that were received as part of an ongoing population-based surveillance. All the Candida isolates were previously identified by a combination of methods, including phenotype and sequence analysis. Results showed that the Luminex assay was an attractive alternative to reference methods, as it is rapid, yields correct species identification, and is user friendly.
Electromigration of Mobile Defects in CdTe (2009)

Electromigration of mobile charged defects in external electric field is investigated at various temperatures and biases in conductive undoped and semiinsulating In-doped CdTe, respectively. A set of electric contacts as potential probes arranged linearly along the sample was used for the detection of the drift of the local resistance modulation. The observed modulation drifting along the sample always from the positive toward negative contact after step-like bias polarity reversion points to the migration of positively charged point defects. Mobility and diffusion coefficient of mobile defects at 100degC and 600degC, respectively are determined. Electromigration of point defects is also tested by low temperature photoluminescence and a model explaining migration of charged defects is suggested.
[Formation of high-molecular aggregates between serum amylase and colloidal plasma substitutes (author's transl)]. (1977)

The distribution of molecular weights of human serum amylase was studied by gel filtration of serum, obtained before and after infusion of the colloidal plasma substitutes hydroxyethyl starch, dextran and gelatin, respectively. Both in serum, drawn after intravenous infusion of hydroxyethyl starch, and in a solution of hydroxyethyl starch with serum we observed a significant increase in the molecular weight of serum amylase. The occurrence of this "macroamylase" may be explained by the formation of aggregates between hydroxyethyl starch and amylase. Because of its high molecular weight the elimination of this, presumably, enzyme-substrate-complex is retarded, thus leading to the observed increase of serum amylase activity. In contrast to these observations concerning hydroxyethyl starch no change in the apparent molecular weight of serum amylase was observed following the infusion of either gelatin or dextran or their solutions with serum.
The Catalytic Properties of Tyrosyl Ribonucleic Acid Synthetases from Escherichia coli and Bacillus subtilis<sup>*</sup> (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Catalytic Properties of Tyrosyl Ribonucleic Acid Synthetases from Escherichia coli and Bacillus subtilis*Richard Calendar and Paul BergCite this: Biochemistry 1966, 5, 5, 1690–1695Publication Date (Print):May 1, 1966Publication History Published online1 May 2002Published inissue 1 May 1966https://pubs.acs.org/doi/10.1021/bi00869a034https://doi.org/10.1021/bi00869a034research-articleACS PublicationsRequest reuse permissionsArticle Views368Altmetric-Citations141LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
HMG CoA reductase inhibition and left ventricular mass in hypertrophic cardiomyopathy: a randomized placebo‐controlled pilot study (2007)

In patients with hypertrophic cardiomyopathy, this randomized placebo-controlled double-blind pilot study did not demonstrate an effect of 9-month treatment with atorvastatin 80 mg on LV mass reduction.
Depth from sliding projections (2009)

In this paper we present a novel method for 3D structure acquisition, based on structured light. Unlike classical structured light methods, in which a static projector illuminates a scene with time-varying illumination patterns, our technique makes use of a moving projector emitting a static striped illumination pattern. This projector is translated at a constant velocity, in the direction of the projector's horizontal axis. Illuminating the object in this manner allows us to perform a per pixel analysis, in which we decompose the recorded illumination sequence into a corresponding set of frequency components. The dominant frequency in this set can be directly converted into a corresponding depth value. This per pixel analysis allows us to preserve sharp edges in the depth image. Unlike classical structured light methods, the quality of our results is not limited by projector or camera resolution, but is solely dependent on the temporal sampling density of the captured image sequence. Additional benefits include a significant robustness against common problems encountered with structured light methods, such as occlusions, specular reflections, subsurface scattering, interreflections, and to a certain extent projector defocus.
Liver resection for hepatocellular carcinoma in patients with cirrhosis (2005)

The results of liver resection for HCC in patients with cirrhosis improved over time. Liver resection remains a good treatment option in selected patients with HCC arising from a cirrhotic liver.
Makro‐ und Mikromischen im Rührkessel (1988)

Abstract Macro‐ and micromixing in stirred tanks. Macromixing time, based on turbulence theory, is calculated theoretically as a function of the specific power input, the kinematic viscosity, the Schmidt number, and the degree of segregation. A comparison of the micromixing time with data for macromixing found in literature reveals that the micromixing time governs the reaction for very small vessel diameters. If the vessel diameter is greater than the critical size than the turbulent macromixing time controls the mixing process. The micromixing time θ mikro is calculated by means of the experimental results of the turbulent velocity distributions in different stirred vessels for several geometrical arrangements of stirred tanks and different positions of feed input. The calculated data for turbulent mixing times are only valid for geometrically optimized stirred vessels. The necessary mixing time may increase or, if a chemical reaction of 2nd order takes place, the desired yield of the product may decrease considerably if the geometrical conditions are not taken into account.
Reduced levels of immunoglobulin in children with autism correlates with behavioral symptoms (2008)

Children with AU have significantly reduced levels of plasma IgG and IgM compared to both DD and TD controls, suggesting an underlying defect in immune function. This reduction in specific Ig levels correlates with behavioral severity, where those patients with the highest scores in the behavioral battery have the most reduced levels of IgG and IgM.
A novel mutation in the coding region of the prosaposin gene leads to a complete deficiency of prosaposin and saposins, and is associated with a complex sphingolipidosis dominated by lactosylceramide accumulation (2001)

A fatal infantile storage disorder with hepatosplenomegaly and severe neurological disease is described. Sphingolipids, including monohexosylceramides (mainly glucosylceramide), dihexosylceramides (mainly lactosylceramide), globotriaosyl ceramide, sulphatides, ceramides and globotetraosyl ceramide, were stored in the tissues. In general, cholesterol and sphingomyelin levels were unaltered. The storage process was generalized and affected a number of cell types, with histiocytes, which infiltrated a number of visceral organs and the brain, especially involved. The ultrastructure of the storage lysosomes was membranous with oligolamellar, mainly vesicular, profiles. Infrequently, there were Gaucher-like lysosomes in histiocytes. The neuropathology was severe and featured neuronal storage and loss with a massive depopulation of cortical neurons and pronounced fibrillary astrocytosis. There was a paucity of myelin and stainable axons in the white matter with signs of active demyelination. Immunohistochemical investigations indicated that saposins A, B, C and D were all deficient. The patient was homozygous for a 1 bp deletion (c.803delG) within the SAP-B domain of the prosaposin gene which leads to a frameshift and premature stop codon. In the heterozygous parents, mutant cDNA was detected by amplification refractory mutation analysis in the nuclear, but not the cytoplasmic, fraction of fibroblast RNA, indicating that the mutant mRNA was rapidly degraded. The storage process in the proband resembled that of a published case from an unrelated family. Saposins were also deficient in this case, leading to its reclassification as prosaposin deficiency, and her mother was found to be a carrier for the same c.803delG mutation. Both of the investigated families came from the same district of eastern Slovakia.
The double-deficit hypothesis for the developmental dyslexias. (1999)

The authors propose an alternative conceptualization of the developmental dyslexias, the double-deficit hypothesis (i.e., phonological deficits and processes underlying naming-speed deficits represent 2 separable sources of reading dysfunction). Data from cross-sectional, longitudinal, and cross-linguistic studies are reviewed supporting the presence of 2 single-deficit subtypes with more limited reading impairments and 1 double-deficit subtype with more pervasive and severe impairments. Naming-speed and phonological-awareness variables contribute uniquely to different aspects of reading according to this conception, with a model of visual letter naming illustrating both the multicomponential nature of naming speed and why naming speed Should not be subsumed under phonological processes. Two hypotheses concerning relationships between naming-speed processes and reading are considered. The implications of processing speed as a second core deficit in dyslexia are described for diagnosis and intervention.
Fractal analysis in the detection of colonic cancer images (2002)

The aim of this study was to investigate the value of fractal dimension in separating normal and cancerous images, and to examine the relationship between fractal dimension and traditional texture analysis features. Forty-four normal images and 58 cancer images from sections of the colon were analyzed. A "leave-one-out" analysis approach was used to classify the samples into each group. With fractal analysis there was a highly significant difference between groups (p < 0.0001). Correlation and entropy features showed greater differences between the groups (p < 0.0001). Nevertheless, the addition of fractal analysis to the feature analysis improved the sensitivity from 90% to 95% and specificity from 86% to 93%.
Detrimental vs. beneficial influence of ions during solar (SODIS) and photo-Fenton disinfection of E. coli in water: (Bi)carbonate, chloride, nitrate and nitrite effects (2020)

In this work, we studied the effect of inorganic ions occurring in natural waters on E. coli inactivation by solar and photo-Fenton processes, two crucial methods for drinking water treatment in sunny or developing countries. HCO3-,Cl-,SO42-,NO3-,NO2- and NH4+ were assessed at relevant concentrations for their inhibiting or facilitating role. The inactivation enhancement during solar disinfection (SODIS) was mainly attributed to the generation of HO• radicals produced during by excitation of NO3-,NO2-, while the HO• of photo-Fenton may be transformed into other radical species in presence of ions. Natural organic matter (NOM) was found to enhance both processes but also to hinder most of the enhancing ions, except for NO2-; modeling with the APEX software unveiled the inter-relations in the presence of NOM, and the possible inactivation activity by NO2•. The photo-Fenton inactivation was more significantly enhanced by ions than SODIS (besides the case of NO3-,NO2-), but both processes were found robust enough.
Management of Enterocutaneous Fistulas (2004)

Despite advances in antimicrobial chemotherapy, nutritional support, and perioperative critical care, the development of an enterocutaneous fistula continues to represent a major therapeutic challenge, with appreciable morbidity and mortality. Specific problems that must be addressed for the successful management of patients with enterocutaneous fistulas are the control of sepsis, maintenance of adequate fluid and electrolyte balance, provision of adequate and complication-free nutritional support, and skin-stoma care. In addition, many patients with postoperative intestinal fistulation suffer from significant psychological morbidity, which must be addressed during often prolonged periods of rehabilitation. The complex nature of the care required for successful management of patients with enterocutaneous fistulas mandates a multidisciplinary team approach, with specialist nurses, dieticians, pharmacists, radiologists, physicians, and surgeons all having important roles to play.
Pharmacogenetic effect of an endothelin-1 haplotype on response to bucindolol therapy in chronic heart failure (2008)

A common endothelin-1 gene haplotype may be a pharmacogenetic predictor of a favorable clinical response to beta-blocker therapy in heart failure patients. The existence of a less common 'high-risk' haplotype could identify a subpopulation of heart failure patients destined to respond poorly to beta-blocker therapies.
Multicasting for multimedia applications (1992)

The authors investigate multicast routing for high-bandwidth delay-sensitive applications in a point-to-point network as an optimization problem. They associate an edge cost and an edge delay with each edge in the network. The problem is to construct a tree spanning the destination nodes, such that it has the least cost, and so that the delay on the path from the source to each destination is bounded. Since the problem is computationally intractable, the authors present an efficient approximation algorithm. Experimental results through simulations show that the performance of the heuristic is near optimal.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Rapid End-Point Quantitation of Prion Seeding Activity with Sensitivity Comparable to Bioassays (2010)

A major problem for the effective diagnosis and management of prion diseases is the lack of rapid high-throughput assays to measure low levels of prions. Such measurements have typically required prolonged bioassays in animals. Highly sensitive, but generally non-quantitative, prion detection methods have been developed based on prions' ability to seed the conversion of normally soluble protease-sensitive forms of prion protein to protease-resistant and/or amyloid fibrillar forms. Here we describe an approach for estimating the relative amount of prions using a new prion seeding assay called real-time quaking induced conversion assay (RT-QuIC). The underlying reaction blends aspects of the previously described quaking-induced conversion (QuIC) and amyloid seeding assay (ASA) methods and involves prion-seeded conversion of the alpha helix-rich form of bacterially expressed recombinant PrP(C) to a beta sheet-rich amyloid fibrillar form. The RT-QuIC is as sensitive as the animal bioassay, but can be accomplished in 2 days or less. Analogous to end-point dilution animal bioassays, this approach involves testing of serial dilutions of samples and statistically estimating the seeding dose (SD) giving positive responses in 50% of replicate reactions (SD(50)). Brain tissue from 263K scrapie-affected hamsters gave SD(50) values of 10(11)-10(12)/g, making the RT-QuIC similar in sensitivity to end-point dilution bioassays. Analysis of bioassay-positive nasal lavages from hamsters affected with transmissible mink encephalopathy gave SD(50) values of 10(3.5)-10(5.7)/ml, showing that nasal cavities release substantial prion infectivity that can be rapidly detected. Cerebral spinal fluid from 263K scrapie-affected hamsters contained prion SD(50) values of 10(2.0)-10(2.9)/ml. RT-QuIC assay also discriminated deer chronic wasting disease and sheep scrapie brain samples from normal control samples. In principle, end-point dilution quantitation can be applied to many types of prion and amyloid seeding assays. End point dilution RT-QuIC provides a sensitive, rapid, quantitative, and high throughput assay of prion seeding activity.