gebhart/patrepeval huggingface dataset:
Blistering time as a parameter for the strength of dermoepidermal adhesion: a systematic review and meta-analysis (2014)

Skin ageing is associated with a flattening of the dermoepidermal junction and a less effective anchoring system, predisposing to bulla formation, trauma and shear-type injuries. An artificial and controlled technique for standardized dermoepidermal separation is the suction blister method, whereby the strength of dermoepidermal adhesion is characterized by blistering time. To identify and quantify influencing factors on blistering time in healthy humans. A search in the Medline and Embase databases (1946 to June 2014) and in reference lists was conducted. In total, results of 146 suction blister experiments in 3418 individuals reported in 59 publications were analysed. The median blister diameter was 6 mm (IQR 5-6) and the median suction pressure was -210 mmHg (IQR -200 to -300), resulting in a median blistering time of 75 min (IQR 48-120). In the multivariate model, skin temperature and age were the strongest predictors for suction blistering time (P < 0·001, R(2) adjusted = 0·707). This strong association between temperature and suction blistering indicates that the dermoepidermal junction loses its strength with increasing skin temperature. This finding supports the practice of skin and tissue cooling to prevent injuries. The increased vulnerability of the skin seems to exist irrespectively of applied mechanical loads. We conclude that blistering time is an important and clinically relevant (outcome) parameter measuring the structural and mechanical integrity of deeper cutaneous layers.
Toward ultrahigh-efficiency aluminum oxide microcavity light-emitting diodes: guided mode extraction by photonic crystals (2002)

In this paper, we present an improved version of microcavity light-emitting diodes, relying on the use of a low-index material, aluminum oxide. Our work addresses in particular the injection scheme required by the insulating nature of this oxide. The device we fabricated demonstrated efficiencies up to 28% in air, using only planar technology. In these structures, most of the emission is guided. We further propose to include photonic crystals to extract this guided light. The design of the photonic crystals are discussed and substantiated by photoluminescence-based experiments.
Intracellular Correlates of Fast (>200 Hz) Electrical Oscillations in Rat Somatosensory Cortex (2000)

Oscillatory activity in excess of several hundred hertz has been observed in somatosensory evoked potentials (SEP) recorded in both humans and animals and is attracting increasing interest regarding its role in brain function. Currently, however, little is known about the cellular events underlying these oscillations. The present study employed simultaneous in-vivo intracellular and epipial field-potential recording to investigate the cellular correlates of fast oscillations in rat somatosensory cortex evoked by vibrissa stimulation. Two distinct types of fast oscillations were observed, here termed "fast oscillations" (FO) (200-400 Hz) and "very fast oscillations" (VFO) (400-600 Hz). FO coincided with the earliest slow-wave components of the SEP whereas VFO typically were later and of smaller amplitude. Regular spiking (RS) cells exhibited vibrissa-evoked responses associated with one or both types of fast oscillations and consisted of combinations of spike and/or subthreshold events that, when superimposed across trials, clustered at latencies separated by successive cycles of FO or VFO activity, or a combination of both. Fast spiking (FS) cells responded to vibrissae stimulation with bursts of action potentials that closely approximated the periodicity of the surface VFO. No cells were encountered that produced action potential bursts related to FO activity in an analogous fashion. We propose that fast oscillations define preferred latencies for action potential generation in cortical RS cells, with VFO generated by inhibitory interneurons and FO reflecting both sequential and recurrent activity of stations in the cortical lamina.
Cloning of human airway 15-lipoxygenase: identity to the reticulocyte enzyme and expression in epithelium (1992)

Lipoxygenases constitute a family of enzymes which are implicated in a variety of inflammatory disorders including asthma. Although the 15-lipoxygenase has been identified as the major route of arachidonic acid metabolism in human lung, airway epithelial cells, eosinophils, and developing red cells, the localization of the enzyme within lung has not been clearly defined. Furthermore, the existence of isoforms of 15-lipoxygenase in different tissues has recently been proposed. To address these issues, we isolated a 2.6-kb cDNA encoding human airway 15-lipoxygenase from a human bronchus cDNA library using a previously characterized reticulocyte 15-lipoxygenase cDNA as a probe. The airway 15-lipoxygenase sequence was found to be identical to that of the reticulocyte-derived clone. Immunocytochemical studies using an antibody to human recombinant 15-lipoxygenase specifically localizes the enzyme to the basal and ciliated cells of the trachea, bronchi, and bronchioles. Staining for 15-lipoxygenase is not present in the airway secretory epithelial cells, epithelial cells located in the gas-exchanging regions of lung, vascular structures, or inflammatory cells. Taken together these results suggest that the 15-lipoxygenase of human lung is identical to that of the reticulocyte enzyme and is preferentially expressed in airway epithelium.
Effect of the blockage ratios of circular stack on the performance of the air-based standing wave thermoacoustic refrigerator using heat pipe (2021)

In this study, the coefficient of performance (COP) and relative coefficient of performance (COPR) of an air-based standing wave thermoacoustic refrigerator (ASWTAR) was investigated. All relevant components of the thermoacoustic refrigerator were fully available in the system. Heat pipes with a total heating power of 30W were installed into the cold-side and hot-side heat exchangers. The circular stacks with plugging ratios of 0.67, 0.71 and 0.74 and the spiral stacks with plugging ratio of 0.74 were tested and compared. The results show that the circular stack is the optimum stack geometry for ASWTAR. Similarly, a circular stack with a blockage ratio of 0.71 has the best performance, producing the lowest cold side temperature (Tc) and the highest temperature difference (ΔTm). Under no cooling load and 2W cooling load, Tc, ΔTm, COP and COPR were 22.4 °C, 30.5 °C, 0.93 and 9.57%, respectively. Finally, it is clear that due to the use of more suitable materials, the COP and COPR of a circular stack are greater than those of a spiral stack.
Corneal Ablation Profiles for Correction of Hyperopia with the Excimer Laser (1996)

Making the central cornea steeper by means of photorefractive keratectomy implies that the periphery should be flattened (axial power). The amount of flattening is directly proportional to the degree of steepening, and is relatively larger if the transition is more abrupt.
Cyclosporine A in Fat Emulsion Carrier: Immunosuppressive Effect In Vitro (1992)

We have recently shown in a rat model that the acute decrease in glomerular filtration rate caused by intravenous Sandimmun can be avoided if Cyclosporine A (CyA) is given in a fat emulsion carrier instead. The present study was undertaken to determine the immunosuppressive effect in vitro of this new formulation. The inhibitory effect on the lymphocyte responsiveness of CyA in fat emulsion carrier was compared with that of CyA dissolved in alcohol, using mitogens as well as alloantigens as stimuli. In the mixed lymphocyte culture and cell-mediated lympholysis tests and in the interleukin-2 assay, both formulations seemed equally effective. CyA in fat emulsion was somewhat less effective than CyA in alcohol in the mitogen tests. In clinical practice the fat emulsion would be rapidly metabolized, and to further evaluate our new formulation, studies in experimental organ transplantation are needed.
ChemInform Abstract: Pd(II)‐Catalyzed Hydroxyl‐Directed C—H Activation/C—O Cyclization: Expedient Construction of Dihydrobenzofurans. (2010)

Abstract Intramolecular cyclization of tertiary phenylethanol derivatives, e.g. (I), (III) or (V), proceeds smoothly in the presence of Pd(II) catalyst and Ph‐I(O‐Ac) 2 to give dihydrobenzofuran derivatives in good yields.
SOME NEW TUBERCULOSTATIC THIOSEMICARBAZONES (1953)

ADVERTISEMENT RETURN TO ISSUEArticleNEXTSOME NEW TUBERCULOSTATIC THIOSEMICARBAZONESNG. PH. BUU-HOÏ, M. WELSCH, G. DECHAMPS, H. Le BIHAN, F. BINON, and NG. D. XUONGCite this: J. Org. Chem. 1953, 18, 2, 121–126Publication Date (Print):February 1, 1953Publication History Published online1 May 2002Published inissue 1 February 1953https://pubs.acs.org/doi/10.1021/jo01130a001https://doi.org/10.1021/jo01130a001research-articleACS PublicationsRequest reuse permissionsArticle Views238Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Controlled clinical trials with prothrombin complex concentrates. (1984)

Since the introduction of PCC for treatment of bleeding episodes in hemophiliacs with inhibitors in 1972, many anecdotal reports and uncontrolled observations have been published, often with conflicting reports of efficacy. To date, three controlled double blind studies have been completed in which PCC have been evaluated. In each of the three studies acute hemarthrosis has been the only (Lusher et al 1980; Lusher et al 1983) or the predominant (Sjamsoedin 1981) type of bleeding evaluated. While acute joint bleeding lends itself well to clinical trial, there are recognized problems in evaluating response to treatment. Despite these limitations, it is noteworthy that non-activated PCC were found to be effective in approximately 50% of episodes in all three trials. Future trials are now being planned in an attempt to determine the role of activated PCC in the management of bleeding episodes in hemophiliacs with inhibitors. In the design of these trials, possible modifications to be considered are the exclusion (or separate randomization) of chronically disabled or "target" joints, more than one dose of unknown product, and longer periods of assessment.
New Type III Effectors from <i>Xanthomonas campestris</i> pv. <i>vesicatoria</i> Trigger Plant Reactions Dependent on a Conserved N-Myristoylation Motif (2007)

Pathogenicity of the gram-negative plant pathogen Xanthomonas campestris pv. vesicatoria depends on a type III secretion system, which translocates bacterial effector proteins into the plant cell. In this study, we identified two novel type III effectors, XopE1 and XopE2 (Xanthomonas outer proteins), using the AvrBs3 effector domain as reporter. XopE1 and XopE2 belong to the HopX family and possess a conserved putative N-myristoylation motif that is also present in the effector XopJ from X. campestris pv. vesicatoria 85-10. XopJ is a member of the YopJ/AvrRxv family of acetyltransferases. Confocal laser scanning microscopy and immunocytochemistry revealed that green fluorescent protein fusions of XopE1, XopE2, and XopJ localized to the plant cell plasma membrane. Targeting to the membrane is probably due to N-myristoylation, because a point mutation in the putative myristoylated glycine residue G2 in XopE1, XopE2, and XopJ resulted in cytoplasmic localization of the mutant proteins. Results of hydroxylamine treatments of XopE2 protein extracts suggest that the proteins are additionally anchored in the host cell plasma membrane by palmitoylation. The membrane localization of the effectors strongly influences the phenotypes they trigger in the plant. Agrobacterium-mediated expression of xopE1 and xopJ in Nicotiana benthamiana led to cell-death reactions that, for xopJ, were dependent on the N-myristoylation motif. In the case of xopE1(G2A), cell death was more pronounced with the mutant than with the wild-type protein. In addition, XopE2 has an avirulence activity in Solanum pseudocapsicum.
In the shadow of politics: US AID-government of Egypt relations and urban housing intervention (2001)

This paper shows how international and local politics influence aid projects, using the example of the Helwan housing project in Cairo funded by the US Government’s Agency for International Development (US AID). Most discussions on aid focus on its economic role, neglecting how politics within donor and recipient countries shape it and often limit its effectiveness. Many aid agencies also assume that they can impose conditions to make “their” project more effective without recognizing the resentment and opposition this generates (which then reduces effectiveness). In describing the implementation of this project, which included upgrading for 200,000 people and 7,200 new serviced sites, the paper also shows the dependency of international donors on recipient government agencies. These agencies have considerable power, both in what they do and in what they choose not to do or to delay. Most of the Helwan’s project’s goals were not achieved. It did not change the government of Egypt’s approach to low-income housing and it did not even meet its goals within the project itself. At the-outset, no consensus was built between the different international, national and local agencies. The donor could not stop the funding in order to enforce project conditionality because it was under pressure to spend the money and because many vested interests would have suffered if the funding had been stopped.
Loran-C expansion: Impact on precise time/time interval (1974)

On 16 May 1974, it was announced that Loran-C was chosen as the navigation system to serve the U. S. Coastal Confluence Zone. At the present time, reliable CONUS Loran-C groundwave timing coverage extends westward only about as far as Boulder, CO. The groundwave hyperbolic and timing coverage which will result from the planned CONUS expansion are illustrated. Time frames are provided. A status report on the planned reduction in Loran-C PTTI tolerances is presented.
HAP: Hybrid-memory-Aware Partition in shared Last-Level Cache (2014)

Data-center servers require large capacity main memory to run multiple workloads simultaneously. However, the scalability and power consumption of DRAM limit its capability of constructing large capacity memory. Emerging non-volatile memories (e.g. PCM and STT-RAM) provide better scalability and lower power leakage than DRAM. Especially, hybrid memory consisting of DRAM and NVM is able to exploit advantages of different memory medias. However, NVMs have a few drawbacks, such as relatively longer read and write latency. Cache miss at the shared last level cache (LLC) suffers from longer latency if the missing data resides in NVM. Current LLC policies manage the cache space without being aware of the underlying heterogeneous medias. This results in cache performance degradation if a large number of missing data come from NVM. Taking the asymmetric cache miss cost into account, we first propose a new performance metric -TMPKI, which can exactly reflect the LLC performance on the top of hybrid memories. Then we propose a hybrid memory aware cache partitioning technique (HAP) to dynamically adjust the cache spaces for DRAM and NVM data based on TMPKI. Experimental results show that HAP improves performance against the traditional LRU policy by up to 54.3% (19.6% on average) while it incurs a little storage overhead (0.2%).
Novel coordination chemistry and catalytic properties of cationic 1,2-bis(diphenylphosphino)ethanerhodium(I) complexes (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNovel coordination chemistry and catalytic properties of cationic 1,2-bis(diphenylphosphino)ethanerhodium(I) complexesJack Halpern, Dennis P. Riley, Albert S. C. Chan, and Joseph J. PluthCite this: J. Am. Chem. Soc. 1977, 99, 24, 8055–8057Publication Date (Print):November 1, 1977Publication History Published online1 May 2002Published inissue 1 November 1977https://doi.org/10.1021/ja00466a051RIGHTS & PERMISSIONSArticle Views1406Altmetric-Citations232LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (415 KB) Get e-Alerts Get e-Alerts
An application of utilizing the system-efficient-ESD-design (SEED) concept to analyze an LED protection circuit of a cell phone (2012)

An LED circuit of a cell phone is analyzed using the System-Efficient-ESD-Design (SEED) methodology. The method allows simulation of the ESD current path, and the interaction mechanisms between the clamp and the on-chip ESD protection circuit. The I-V curve and the non-linear behavior under high current pulses of every component including R, L, C, and ferrite beads are measured and modeled. By combining all of the component models, a complete circuit model is built for predicting the circuit behavior and damaging threshold at a given setting-voltage of a Transmission Line Pulser (TLP).
Low-temperature vapour deposition of high-purity copper coatings from bis[N-(fluoroalkyl)salicylaldiminato]copper chelates (1991)

High-purity copper coatings have been prepared by chemical vapour deposition at low temperature from two nove bis[N-(fluoroalkyl)salicylaldiminato] chelates of copper(II). When hydrogen is used as the carrier gas at ambient pressure, copper coatings containing < 1 atom.% carbon, oxygen, nitrogen, and fluorine are generated at 290 and 330 °C using Cu(NCH2CF2CF3-SAL)2 and Cu(NCH2CF2CF2CF3-SAL)2, respectively (SAL = salicylaldiminato). When the deposition is carried out in vacuo, ca. 6% carbon, 2% oxygen, and 3% fluorine are incorporated into the films using Cu(NCH2CF2CF3-SAL)2 as the copper source.
An approach to the synthesis of neplanocin A (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAn approach to the synthesis of neplanocin AWilliam C. Faith, Carlye A. Booth, Bruce M. Foxman, and Barry B. SniderCite this: J. Org. Chem. 1985, 50, 11, 1983–1985Publication Date (Print):May 1, 1985Publication History Published online1 May 2002Published inissue 1 May 1985https://doi.org/10.1021/jo00211a041RIGHTS & PERMISSIONSArticle Views359Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (420 KB) Get e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Hexagonal phase in tensile LPCVD poly-Si film (1991)

This report discusses the microstructure, and phase transformation of hexagonal phase tensile LPCVD poly-silicon films. (JL)
Studies on the hydrolysis of lecithin by a <i>Penicillium notatum</i> phospholipase <i>B</i> preparation (1958)

Research Article| December 01 1958 Studies on the hydrolysis of lecithin by a Penicillium notatum phospholipase B preparation R. M. C. Dawson R. M. C. Dawson 1Biochemistry Department, Agricultural Research Council, Institute of Animal Physiology, Babraham, Cambridge Search for other works by this author on: This Site PubMed Google Scholar Biochem J (1958) 70 (4): 559–570. https://doi.org/10.1042/bj0700559 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation R. M. C. Dawson; Studies on the hydrolysis of lecithin by a Penicillium notatum phospholipase B preparation. Biochem J 1 December 1958; 70 (4): 559–570. doi: https://doi.org/10.1042/bj0700559 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search © 1958 CAMBRIDGE UNIVERSITY PRESS1958 Article PDF first page preview Close Modal You do not currently have access to this content.
Human Immune Associated Nucleotide 1: a member of a new guanosine triphosphatase family expressed in resting T and B cells (2002)

TAL-1 is a basic helix-loop-helix oncoprotein that is expressed in up to 30% of T-cell acute lymphoblastic leukemias but not in the T lineage. We have cloned a complementary DNA, called Human Immune Associated Nucleotide 1 (hIAN1), whose messenger RNA (mRNA) level expression is inversely correlated to the TAL-1 mRNA level in human leukemic T-cell lines. The hIAN1 encodes a 38-kd protein that belongs to a novel family of proteins conserved from plants to humans and characterized by motifs related to, but highly divergent from, the consensus motifs found in guanosine triphosphate (GTP)-binding proteins. Despite these divergent amino acids at positions involved in GTP/guanosine diphosphate (GDP) binding and guanosine triphosphatase (GTPase) activities, we found that hIAN1 specifically binds GDP (K(d) = 0.47 microM) and GTP (K(d) = 6 microM) and exhibits intrinsic GTPase activity. Among mature hematopoietic cells, hIAN1 is specifically expressed in resting T and B lymphocytes, and its expression level tremendously decreased at the protein but not the mRNA level during B- or T-lymphocyte activation, suggesting a specific role for this new type of GTPase during the immune response.