gebhart/patrepeval huggingface dataset:
Quantifying pharmacologic suppression of cellular senescence: prevention of cellular hypertrophy versus preservation of proliferative potential (2009)

Development of agents that suppress aging (aging suppressants) requires quantification of cellular senescence. Cellular senescence in vitro is characterized by a large cell morphology and permanent loss of proliferative potential. When HT-1080 cells were arrested by p21, they continued to grow exponentially in size and became hypertrophic with a 15-fold increase in the protein content per cell. These changes were mirrored by accumulation of GFP (driven by CMV promoter) per cell, which also served as a marker of cellular hypertrophy. Preservation of proliferative potential (competence) was measured by an increase in live cell number, when p21 was switched off. While modestly decreasing hypertrophy in p21-arresrted cells, rapamycin considerably preserved competence, converting senescence into quiescence. Preservation of proliferative potential (competence) correlated with inhibition of S6 phosphorylation by rapamycin. When p21 was switched off, competent cells, by resuming proliferation, became progressively less hypertrophic. Preservation of proliferative potential is a sensitive and quantitative measure of suppression of mTOR-driven senescence.
Seismogram Picking Error from Analyst Review (SPEAR): Single-Analyst and Institution Analysis (2009)

Abstract We perform two experiments to define and isolate errors associated with picking seismic phases (the process of naming and measuring the arrivals of seismic phases). The first experiment establishes a method and model to describe picking errors for a single analyst measuring arrivals recorded on short-period instruments. The analyst’s picks are constrained to earthquakes that had similar epicenters with stations at local to near-regional distances. We find that the main source of error for an individual analyst is the signal-to-noise ratio (SNR) measured using a wideband spectral ratio (WSR). The pick error is 0.1 sec for measurements made with a WSR greater than 10. In some cases, errors that occur with high WSR (>10) appear to result from the variability of the seismic signals, caused through magnitude or scaling differences and source specific differences. The second experiment confirms our hypothesis that institutions have approaches in measuring seismic arrivals that inherently cause the pick placement to differ from institute to institute. For the institute analysis, we use data collected from the International Seismological Center (ISC). The SNR is not reported in the ISC catalogs; however, we show that the distance from station to source is a factor that can define the error between picks made at different institutions. The error between picks increases with distance until the transition from regional phases to teleseismic (∼20–30°), where the error is decreased by over 50%. The error then begins to increase after 40°. Another factor of error may be that institutions name seismic phases differently. We also perform a one-way multivariate analysis of variance on the institutions and the pick information to show the institutions pick differently. Measurement differences between institutions are greater than measurement differences of a single analyst. The single-analyst measurement error can be defined as 0.1 sec for an experienced analyst picking local to regional phases on short-period instruments that have a WSR greater than 10. However, this precision level of measurement error is not valid when combining picks from multiple institutions. We need to define a new measurement error model for combining picks to establish velocity and earth models when merging data from multiple institutions; a seismic phase picking error model cannot be established from the current earthquake catalogs.
Synthesis of polyethylene‐grafted multiwalled carbon nanotubes via a peroxide‐initiating radical coupling reaction and by using well‐defined TEMPO and thiol end‐functionalized polyethylenes (2011)

Abstract Polyethylene (PE), alkoxyamine‐ and thiol‐terminated PEs (PE‐TEMPO and PE‐SH, respectively) can be converted to macroradicals using a peroxide, a thermal cleavage of the alkoxyamine and a hydrogen transfer reaction of the thiol, respectively. The addition of these macroradicals to multiwalled carbon nanotubes (MWCNTs) were compared by performing grafting reactions at 160 °C in 1,3‐dichlorobenzene as solvent. Raman spectroscopy was utilized to follow the introduction of PE on the MWCNTs' surface while thermogravimetric and elemental analysis indicated the extent of this grafting. The grafting ratio was found to be in the range of 19–36 wt %. PE‐functionalized MWCNTs were imaged by transmission electronic microscopy showing a PE layer with various thicknesses covering the surface of nanotubes. It was found that higher levels of grafting were obtained using PE‐2,2,6,6‐tetramethylpiperidinyl‐1‐oxy and PE‐SH rather than a radical grafting reaction in which dicumyl peroxide, PE, and MWCNTs were reacted. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2011
L'Information, ses droits et ses responsabilités (1948)

info:eu-repo/semantics/published
Maintenance and Repair of the Lung Endothelium Does Not Involve Contributions from Marrow-Derived Endothelial Precursor Cells (2012)

Lung endothelium is believed to be a quiescent tissue with the potential to exhibit rapid and effective repair after injury. Endothelial progenitor cells derived from the bone marrow have been proposed as one source of new endothelial cells that may directly contribute to pulmonary endothelial cell homeostasis and repair. Here we use bone marrow transplantation models, using purified hematopoietic stem cells (HSCs) or unfractionated whole marrow, to assess engraftment of cells in the endothelium of a variety of tissues. We find scant evidence for any contribution of bone marrow-derived cells to the pulmonary endothelium in the steady state or after recovery from hyperoxia-induced endothelial injury. Although a rare population of CD45-/CD31+/VECadherin+ bone marrow-derived cells, originating from HSCs, can be found in lung tissue after transplantation, these cells are not readily found in anatomic locations that define the pulmonary endothelium. Moreover, by tracking transplanted bone marrow cells obtained from donor transgenic mice containing endothelial lineage-selective reporters (Tie2-GFP), no contribution of bone marrow-derived cells to the adult lung, liver, pancreas, heart, and kidney endothelium can be detected, even after prolonged follow-up periods of 11 months or after recovery from hyperoxic pulmonary endothelial injury. Our findings argue against any significant engraftment of bone marrow-derived cells in the pulmonary vascular endothelium.
A Novel Mitochondrial Carnitine-acylcarnitine Translocase Induced by Partial Hepatectomy and Fasting (2003)

The carnitine-dependent transport of long-chain fatty acids is essential for fatty acid catabolism. In this system, the fatty acid moiety of acyl-CoA is transferred enzymatically to carnitine, and the resultant product, acylcarnitine, is imported into the mitochondrial matrix through a transporter named carnitine-acylcarnitine translocase (CACT). Here we report a novel mammalian protein homologous to CACT. The protein, designated as CACL (CACT-like), is localized to the mitochondria and has palmitoylcarnitine transporting activity. The tissue distribution of CACL is similar to that of CACT; both are expressed at a higher level in tissues using fatty acids as fuels, except in the brain, where only CACL is expressed. In addition, CACL is induced by partial hepatectomy or fasting. Thus, CACL may play an important role cooperatively with its homologue CACT in a stress-induced change of lipid metabolism, and may be specialized for the metabolism of a distinct class of fatty acids involved in brain function.
Self-stabilized gradient algorithms for blind source separation with orthogonality constraints (2000)

Recently, developments in self-stabilized algorithms for gradient adaptation of orthonormal matrices have resulted in simple but powerful principal and minor subspace analysis methods. In this paper, we extend these ideas to develop algorithms for instantaneous prewhitened blind separation of homogeneous signal mixtures. Our algorithms are proven to be self-stabilizing to the Stiefel manifold of orthonormal matrices, such that the rows of the adaptive demixing matrix do not need to be periodically reorthonormalized. Several algorithm forms are developed, including those that are equivariant with respect to the prewhitened mixing matrix. Simulations verify the excellent numerical properties of the proposed methods for the blind source separation task.
Automated detection and delineation of lung tumors in PET-CT volumes using a lung atlas and iterative mean-SUV threshold (2009)

Automated segmentation for the delineation of lung tumors with PET-CT is a challenging task. In PET images, primary lung tumors can have varying degrees of tracer uptake, which sometimes does not differ markedly from normal adjacent structures such as the mediastinum, heart and liver. In addition, separation of tumor from adjacent soft tissues and bone in the chest wall is problematic due to limited resolution. For CT, the tumor soft tissue density can be similar to that in the blood vessels and the chest wall; and although CT provides better boundary definition, exact tumor delineation is also difficult when the tumor density is similar to adjacent structures. We propose an innovative automated adaptive method to delineate lung tumors in PET-CT images in conjunction with a lung atlas in which an iterative mean-SUV (Standardized Uptake Value) threshold is used to gradually define the tumor region in PET. Tumor delineation in the CT data is performed using region growing and seeds obtained autonomously from the PET tumor regions. We evaluated our approach in 13 patients with non-small cell lung cancer (NSCLC) and found it could delineate tumors of different size, shape and location, even when when the NSCLC involved the chest wall.
The 'universal' dielectric response. I (1990)

A novel approach to the interpretation of the dielectric response of solids, in terms of the concept of the universal dielectric law of relaxation, is presented. The universal approach moves away from the earlier interpretations that relied heavily on the concept of distributions of relaxation times (DRTs) of Debye-like processes that are supposed to coexist in a given material and constitute a superficially plausible model. It is argued that the DRT explanations do not stand up to critical examination. The new interpretation is based on the unique property of the empirically determined fractional power laws in frequency that the ratio of the imaginary to the real parts of the complex dielectric susceptibility is independent of frequency, in sharp contrast to the Debye law, where the ratio is proportional to frequency. The significance of the approach is illustrated by showing, in connection with the interpretation of low-frequency dispersion, that it impinges on many phenomena in physical chemistry and electrochemistry. It can also be used to advantage to study the delayed transitions of localized electrons in semiconductors and similar materials.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Handbook of poisoning: diagnosis & treatment (1971)

Concise summary of diagnosis and treatment of clinically important poisons. Poisons arranged according to type, i.e., agricultural, household, medicinal, industrial, animal, and plant. Clinical findings, prevention, treatment, and prognosis are given for each poison. General index.
The QuadCAT™ Four-Way Catalytic Converter: An Integrated Aftertreatment System for Diesel Engines (1999)

<div class="htmlview paragraph">Increasingly stringent emission regulations within the diesel engine industry, particularly with regard to particulate matter and oxides of nitrogen, have led to the development of a number of aftertreatment control technologies. Most of these control technologies address either oxides of nitrogen (NOx) emissions or particulate matter (PM) emissions, but not both. Until now no technologies were available that simultaneously reduced both these pollutants.</div> <div class="htmlview paragraph">Ceryx Incorporated has developed a novel four-way converter for the simultaneous reduction of PM, NOx, CO, and HC from diesel engines. The Ceryx systems integrate diesel particulate filters (DPF's) and lean NOx catalysts (LNC's) in the core of a proprietary heat exchanger. The heat exchanger serves to “recycle” heat from exothermic reactions over the catalyst by transferring heat from the hot exit gases to the cooler inlet gases. The regeneration performance of the DPF and the NOx reduction performance of the LNC are greatly enhanced by keeping them at an elevated temperature, particularly at light load conditions.</div> <div class="htmlview paragraph">Emissions and performance testing of the device placed on a modern 12-liter heavy-duty diesel and dual-fueled engine have demonstrated proof of concept. The results have demonstrated greater than 95% CO &amp; HC oxidation, 90% particulate oxidation, and up to 46% NOx reduction. These results show that the device will enable a modern (circa 1996) engine to achieve the upcoming EPA 2004/2002 and Euro IV (2005) standards for heavy-duty engines without significant engine performance or fuel penalty. This paper details the principles of operation of the QuadCAT Four-Way Converter and reports the results of recent full-scale engine dynamometer tests.</div>
Accelerator Structure Development for NLC/GLC (2004)

The NLC (Next Linear Collider) and GLC (Global Linear Collider) [1,2] are e{sup +}e{sup -} linear collider proposals based on room-temperature accelerator technology--so called ''warm machines'' in comparison with the TESLA ''cold machine'' that is based on superconducting accelerator technology. There have been two major challenges in developing X-band (11.4 GHz) accelerator structures for the GLC/NLC. The first is to demonstrate stable, long-term operation at the high gradient (65 MV/m) that is required to optimize the machine cost. The second is to strongly suppress the beam induced long-range wakefields, which is required to achieve high luminosity. The development of high gradient structures has been a high priority in recent years. Nearly thirty X-band structures with various rf parameters, cavity shapes and coupler types have been fabricated and tested since 2000. This program has been a successful collaborative effort among groups at SLAC, KEK, FNAL and other labs. A summary of the main achievements and experiences are presented in this paper as well as a status report on the structure design, high power performance, manufacturing techniques, and other structure related issues.
Risk of Infectious Disease Outbreaks by Imported Cases with Application to the European Football Championship 2012 (2013)

The European Centre for Disease Prevention and Control called the attention in March 2012 to the risk of measles in Ukraine among visitors to the 2012 UEFA European Football Championship. Large populations of supporters travelled to various locations in Poland and Ukraine, depending on the schedule of Euro 2012 and the outcome of the games, possibly carrying the disease from one location to another. In the present study, we propose a novel two-phase multitype branching process model with immigration to describe the risk of a major epidemic in connection with large-scale sports-related mass gathering events. By analytic means, we calculate the expected number and the variance of imported cases and the probability of a major epidemic caused by the imported cases in their home country. Applying our model to the case study of Euro 2012 we demonstrate that the results of the football games can be highly influential to the risk of measles outbreaks in the home countries of supporters. To prevent imported epidemics, it should be emphasized that vaccinating travellers would most efficiently reduce the risk of epidemic, while requiring the minimum doses of vaccines as compared to other vaccination strategies. Our theoretical framework can be applied to other future sport tournaments too.
Spectroscopy of transient species produced by photodissociation or photoionization in a supersonic free-jet expansion (1986)

Transient species have been produced and characterized in a supersonic free-jet expansion, which served to cool them and hence simplify their laser-induced fluorescence spectra. A brief description of the technique is given. The results for several varieties of transient species are then overviewed. Species studied include isolated molecular ions, ionic clusters, small neutral free radicals and moderate-sized organic free radicals.
Gas Evolution of Overlithiated Li<sub>2</sub>NiO<sub>2</sub> as Cathode Active Material for Li-Ion Rechargeable Batteries and Al<sub>2</sub>O<sub>3</sub> Coating to Suppress the Gas Evolution (2010)

Abstract not Available.
Coupled ligand chromatography, applications to trace element collection and characterization (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCoupled ligand chromatography, applications to trace element collection and characterizationAlbert J. Bauman, Howard H. Weetall, and Norman. WelikyCite this: Anal. Chem. 1967, 39, 8, 932–935Publication Date (Print):July 1, 1967Publication History Published online1 May 2002Published inissue 1 July 1967https://pubs.acs.org/doi/10.1021/ac60252a026https://doi.org/10.1021/ac60252a026research-articleACS PublicationsRequest reuse permissionsArticle Views48Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Ge Waveguide Photodetectors with Responsivity Roll-off beyond 1620 nm Using Localized Stressor (2012)

We report a novel Ge waveguide photodetector and the fabrication on silicon-on- insulator (SOI) platform. Localized stressor structures were incorporated to tune the responsivity roll-off wavelength. With the localized stressor structure, the roll-off in responsivity is found to be red-shifted from 1520 nm to beyond 1620 nm, i.e., a flat responsivity over the entire C- and L-band is obtained. This technique makes Ge a promising material for fabricating monolithic high- responsivity receivers covering the entire C- and L-band fiber optic communications.
Fluorogenically Active Leucine Zipper Peptides as Tag–Probe Pairs for Protein Imaging in Living Cells (2009)

All zipped up: Pairs of leucine zipper peptides with a solvatochromic fluorescent dye show fluorogenic activity through formation of a 3α-helical bundle structure. Such peptides enable the in situ fluorescence imaging of proteins in the presence of excess fluorescent probe (see picture). Imaging of membrane-bound protein is demonstrated using these zipper peptides as functional tag–probe pairs.
Post‐transcriptional regulation of the Brn‐3b transcription factor in differentiating neuroblastoma cells (2007)

The post-transcriptional control of mRNA levels is a very powerful mechanism which allows cells to quickly change the amount of specific proteins. In this study, we wanted to analyze whether the Brn-3b transcription factor, essential for the proper development of mouse retinal ganglion cells, is subjected to such post-transcriptional regulation. In particular, due to its conservation amongst different species, we wanted to study the role of its 3' untranslated region (3'UTR). We show that the 3'UTR of the Brn-3b mRNA does indeed contain regulatory sequences that mediate mRNA degradation upon serum starvation-induced differentiation of ND7 neuroblastoma cells. The specific region mediating this effect has been characterized and two different microRNAs that potentially regulate the stability of Brn-3b have been identified. Moreover we show that Dicer, one of the key enzymes in the production of microRNAs, is strongly up-regulated in ND7 cells subjected to differentiation.
Direct reprogramming of mouse fibroblasts into cardiomyocytes with chemical cocktails (2015)

The direct conversion, or transdifferentiation, of non-cardiac cells into cardiomyocytes by forced expression of transcription factors and microRNAs provides promising approaches for cardiac regeneration. However, genetic manipulations raise safety concerns and are thus not desirable in most clinical applications. The discovery of full chemically induced pluripotent stem cells suggest the possibility of replacing transcription factors with chemical cocktails. Here, we report the generation of automatically beating cardiomyocyte-like cells from mouse fibroblasts using only chemical cocktails. These chemical-induced cardiomyocyte-like cells (CiCMs) express cardiomyocyte-specific markers, exhibit sarcomeric organization, and possess typical cardiac calcium flux and electrophysiological features. Genetic lineage tracing confirms the fibroblast origin of these CiCMs. Further studies show the generation of CiCMs passes through a cardiac progenitor stage instead of a pluripotent stage. Bypassing the use of viral-derived factors, this proof of concept study lays a foundation for in vivo cardiac transdifferentiation with pharmacological agents and possibly safer treatment of heart failure.
Application of color-coded digital subtraction angiography in treatment of indirect carotid-cavernous fistulas: Initial experience (2013)

This postprocessing method does not require extra radiation exposure and contrast media. It facilitates real-time hemodyamic monitoring and may help determining the endpoint of embolization, which increases patient safety.
Development of a reservoirless thermionic energy converter. (1966)

Covers advancements in spacecraft and tactical and strategic missile systems, including subsystem design and application, mission design and analysis, materials and structures, developments in space sciences, space processing and manufacturing, space operations, and applications of space technologies to other fields.
[Primary pulmonary hypertension]. (2001)

Primary pulmonary hypertension is a rare and poor prognostic disease. This disease has a pulmonary arteriopathy that is due to unknown cause. Histological study shows medial hypertrophy and fibrosis. Plexogenic arteriopathy is usually observed, but not always. Recently gene mutation was discovered in familial primary pulmonary hypertension. Differential diagnosis is very important because therapies are much different among pulmonary hypertensions due to other causes. In the near future, the mechanism of the disease will be apparent, and therapy must be improved.