gebhart/patrepeval huggingface dataset:
Synthesis and anti-deoxyribonucleic acid virus activity of certain 9-.beta.-D-arabinofuranosyl-2-substituted adenine derivatives (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and anti-deoxyribonucleic acid virus activity of certain 9-.beta.-D-arabinofuranosyl-2-substituted adenine derivativesKenji Miyai, Lois B. Allen, John H. Huffman, Robert W. Sidwell, and Richard L. TolmanCite this: J. Med. Chem. 1974, 17, 2, 242–244Publication Date (Print):February 1, 1974Publication History Published online1 May 2002Published inissue 1 February 1974https://pubs.acs.org/doi/10.1021/jm00248a023https://doi.org/10.1021/jm00248a023research-articleACS PublicationsRequest reuse permissionsArticle Views69Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
De Novo Mutations (GAG Deletion) in the DYT1 Gene in Two Non-Jewish Patients with Early-onset Dystonia (1998)

The DYT1 gene recently has been cloned and shown to contain a three nucleotide (GAG) deletion responsible for most cases of autosomal dominant early-onset torsion dystonia. This deletion results in the loss of one of a pair of glutamic acids in a conserved region of a novel ATP-binding protein (torsinA). Previous haplotype analysis revealed that this same deletion had arisen at least two different times in history, suggesting independent mutational events. This deletion is the only sequence change found thus far to be associated uniquely with the disease status, regardless of ethnic origin. Here we describe two patients with typical early-onset torsion dystonia of Swiss-Mennonite and non-Jewish Russian origin, respectively, that both carry this same mutation as a de novo GAG deletion. This finding proves that this 3 bp deletion in the DYT1 gene is indeed a mutation that causes early-onset torsion dystonia. The DYT1 mutation is one of the rare examples of the same recurrent mutation causing a dominantly inherited condition. The sequence surrounding the GAG deletion contains an imperfect 24 bp tandem repeat, suggesting a possible mechanism for the high frequency of this mutation.
Prokaryotic expression and renaturation of anti-idiotype nanobody against aflatoxin B1. (2013)

Objective To rapidly produce a large amount of anti-idiotype nanobody against aflatoxin B 1 (AFB 1 ).Methods Prokaryotic expression vector pET22b-F7 were constructed,and then transformed into E.coli BL21(DE3) for expression of anti-idiotype nanobody against aflatoxin B 1 (AFB 1 ).The conditions such as temperature,concentration of inducer,and induction time were optimized.Results The expression quantity of anti-idiotype nanobody F7 increased,with the main form of inclusion body.Anti-idiotype nanobody against AFB1 with bioactivity were obtained after dissolution and renaturation.ELISA results indicated that the rena- tured protein had the properties of combination with AFB 1 antibody.Conclusion It provides a reference for further study of properties and subsequent transformation.
A 3.3 GHz LC-based digitally controlled oscillator with 5kHz frequency resolution (2007)

This paper reports a LC-based digitally controlled oscillator (DCO) with an enhanced frequency resolution and an extended linear frequency tuning range. It has a center frequency of 3.3GHz and a frequency tuning range of 600MHz covered by 64 different frequency bands. Each frequency band has 2048 linear tuning levels with a frequency step of 5kHz. This DCO was implemented in 90nm CMOS and the measured frequency tuning characteristics are provided in this paper. The DCO exhibits a phase noise of −118dBc/Hz at 1MHz frequency offset. The DCO core consumes 2mA current from 1.2V supply.
Current tests for antibody to hepatitis B core antigen used to screen donors for non‐A, non‐B hepatitis are comparable to the original radioimmunoassay for hepatitis B core antigen (1987)

Prospective studies have shown a relationship between the transfusion of donor blood which is positive for antibodies to hepatitis B core antigen (anti-HBc) and an increased incidence of non-A, non-B hepatitis. The anti-HBc test was selected on the assumption that epidemiologic circumstances predisposing donors to hepatitis B infection also might favor exposure to non-A, non-B hepatitis. Current radioimmunoassays (RIA) and enzyme-linked immunoassays (EIA) for anti-HBc utilize hepatitis B core antigen (HBcAg) prepared by recombinant DNA technology, whereas the original RIA anti-HBc assay used HBcAg derived from hepatitis B virions. In the current study, 1329 sera were evaluated of which 23.3 percent were anti-HBc positive. The results indicate that sensitivity, specificity, and positive and negative predictive values of the current EIA and RIA tests for anti-HBc (Abbott Diagnostic Laboratories) are virtually identical to the original RIA test kit. In addition, all donor samples (128 specimens) administered to 57 cases of non-A, non-B hepatitis that were prospectively followed at Baylor College of Medicine for the Transfusion-Transmitted Viruses (TTV) Study group were retested with the EIA-recombinant anti-HBc assay. All 21 samples which were reactive in the original RIA anti-HBc test also were positive by the current EIA procedure. One sample was EIA positive/RIA negative, and 106 other samples were negative by both assays. Thus, commercial anti-HBc kits based on HBcAg derived by recombinant DNA technology, should retain their predictive value for reducing the incidence of non-A, non-B hepatitis as described in the prospective studies.
EVIDENCE FOR SEXUAL ATTRACTION BY THE TWOLINED CHESTNUT BORER, <i>AGRILUS BILINEATUS</i> (WEBER) (COLEOPTERA: BUPRESTIDAE) (1988)

In the eastern deciduous forests of North America, oaks ( Quercus spp.) that have been weakened by stress are often attacked and killed by the twolined chestnut borer, Agrilus bilineatus (Weber) (Dunn et al. 1986a). This borer attacks stressed and dying trees but does not attack healthy or dead trees (Haack and Benjamin 1982; Dunn et al. 1986a, 1987).
Controlling coverage of solution cast materials with unfavourable surface interactions (2014)

Creating uniform coatings of a solution-cast material is of central importance to a broad range of applications. Here, a robust and generic theoretical framework for calculating surface coverage by a solid film of material de-wetting a substrate is presented. Using experimental data from semiconductor thin films as an example, we calculate surface coverage for a wide range of annealing temperatures and film thicknesses. The model generally predicts that for each value of the annealing temperature there is a range of film thicknesses leading to poor surface coverage. The model accurately reproduces solution-cast thin film coverage for organometal halide perovskites, key modern photovoltaic materials, and identifies processing windows for both high and low levels of surface coverage.
Talking Shop and Shooting the Breeze (2010)

Past research has examined women’s subjective satisfaction in science, technology, engineering, and math (STEM), but the actual events that correlate with disengagement have not been identified. In this study, workplace conversations of 45 female and male STEM faculty were sampled using the Electronically Activated Recorder, a naturalistic observation method, coded for research or socializing content, and correlated with self-reported job disengagement. Both men and women were less likely to discuss research in conversations with female as compared to male colleagues, and when discussing research with men, women were rated as less competent than men. Consistent with the idea that women in STEM experience social identity threat, discussing research with male colleagues was associated with greater disengagement for women, whereas socializing with male colleagues was associated with less disengagement. These patterns did not hold for men. These findings point to the unique challenges women face in STEM disciplines.
Homogenous Alloys of Formamidinium Lead Triiodide and Cesium Tin Triiodide for Efficient Ideal‐Bandgap Perovskite Solar Cells (2017)

The alloying behavior between FAPbI<sub>3</sub> and CsSnI<sub>3</sub> perovskites is studied carefully for the first time, which has led to the realization of single-phase hybrid perovskites of (FAPbI<sub>3</sub> )<sub>1-x</sub> (CsSnI<sub>3</sub> )<sub>x</sub> (0<x<1) compositions with anomalous bandgaps. (FAPbI<sub>3</sub> )<sub>1-x</sub> (CsSnI<sub>3</sub> )<sub>x</sub> perovskites exhibit stable, homogenous composition/microstructure at the nanoscale, as confirmed by microscopic characterization. The ideal bandgap of 1.3 eV for single-junction solar cell operation is achieved in the rationally-tailored (FAPbI<sub>3</sub> )<sub>0.7</sub> (CsSnI<sub>3</sub> )<sub>0.3</sub> -composition perovskite. Solar cells based on this new perovskite show power conversion efficiency up to 14.6 %.
Relative Trajectory Estimation During Chang'e-2 Probe's Flyby of Asteroid Toutatis Using Dynamics, Optical, and Radio Constraints (2016)

The mystery of the asteroid (4179) Toutatis was revealed by Chang'e-2 spacecraft during a close flyby on December 13, 2012. Optical imaging and navigation of the probe during the flyby were performed entirely under ground-based radio tracking and default sequence built on ground. This paper establishes a set of estimation algorithms of the relative trajectory between Chang'e-2 and Toutatis based on dynamics, optical, and radio constraints that are determined by the unique flyby mode. This study is the first time to precisely reproduce the core process of Chang'e-2's encounter with Toutatis based on several optical images. In addition to constructing a strict photogrammetric model, the shadowing effects caused by the illumination and the deviation of the center-of-mass (COM) from the center-of-figure (COF) in optical images are also considered. The spacecraft trajectory with regard to the COF of the body is estimated using images taken from 120 km or less. The formal one sigma uncertainty is (67, 20, and 11 m) in the principal axes frame of the position error ellipse, and the closest approaching distance between Chang'e-2 and Toutatis's COF is calculated as 1557 ± 11 m, which is more precise than previous results with an uncertainty of hundreds of meters. The spacecraft trajectory with regard to the COM of the body is estimated with an uncertainty of (211, 34, and 17 m), and the corresponding closest distance is estimated as 1451 ± 18 m based on the previously developed shape model of Toutatis. The algorithms and results in this study are important for evaluating the performance of this flyby mission and are also valuable for any similar optical navigation during a close approach. In addition, our results can help in precisely determining the axis of Toutatis and sizes of impact craters, which are critical for understanding the formation and evolution of Toutatis.
Studies on the production of bioactive metabolites by marine microalgae (1999)

A free-swimming dinoflagellate, Amphidinium operculatum var. gibbosum, strain S1-36-5, was previously reported to produce a series of antitumor metabolites, amphidinolides. In this dissertation research, the chemical profiles of the cells from different cultures were examined. The results showed that large amounts of amphidinolide B were found only in the older cells (17 days old). However, relatively large amounts of caribenolide 1, the most potent antitumor macrolide found in this species, were also found in the younger cells (7 days old). This result indicated that caribenolide I can be produced in a more efficient way (e.g. continuous culture). Four major cytotoxic compounds, amphidinolides B, G, H and caribenolide I, were isolated from the cells harvested from a semi-continuous culture by chromatography and characterized by spectroscopic techniques. Amphidinolide G was isolated for the first time from A. operculatum var. gibbosum . In contrast, no amphidinolide was isolated from the cells of a 15,000 liter culture. Two lipid compounds were isolated from the second batch of culture, and their bioactivity is under investigation. The low content of the secondary metabolites in 15,000 liter culture was thought to be due to the culture conditions, such as the light deficiency and the nutrient composition changes caused by the contaminants. Studies on the production of extracellular metabolites of Pseudo-nitzschia multiseries indicated that the production of domoic acid depended on the age of the culture. The organism in the older culture seemed to release more domoic acid into the medium rather than keeping it in the cells. A novel extracellular metabolite, bacillariolide III, was isolated from the culture medium, and the structure was determined by NMR, IR, MS and UV-vis. The structure of bacillariolide III was related to bacillariolide I, a phospholipase A 2 inhibitor, previously isolated from the cells of the same organism. The biosynthetic relationship of the two metabolites was proposed. A preliminary experiment indicated that bacillariolide III seemed to stimulate the growth of another diatom Skeletonema costatum. In addition, experiments were carried out as part of the ongoing studies on the biosynthesis of amphidinolides and domoic acid, and the results were discussed.
Fast, Clean and Low Damage Deprocessing Using Inductively Coupled and RIE Plasmas (1996)

Abstract Keeping devices active during deprocessing can be a major frustration for reliability engineers. Reactive ion etching (RIE) provides a rapid, controlled and acid-free method for delayering integrated circuits. However, RIE places a working device directly on a powered electrode, and this can produce surface contamination, charge damage, and waste many man-hours by destroying one-of-a-kind parts. This paper discusses a new reactor type which solves these problems, the inductively coupled plasma (ICP) source. A comparison of etch results (etch rate, surface cleanliness and plasma voltages) was performed in both reactive ion and inductively coupled plasma systems. Scanning electron microscopy (SEM) and surface analysis using scanning Auger spectroscopy were performed. Significant improvements in etch profiles and cleanliness of deprocessing were found.
Validity of Divided Attention Tasks In Predicting Falls in Older Individuals: A Preliminary Study (2002)

The WWT is a reliable and valid test to identify older individuals at high risk for falls. Future studies with larger sample sizes and in different settings are needed to confirm the findings of this study.
Reactions of Fatty Materials with Oxygen. XII. New Method for Concentrating Long-chain Peroxides<sup>2,3</sup> (1952)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions of Fatty Materials with Oxygen. XII. New Method for Concentrating Long-chain Peroxides2,3Joseph E. Coleman, H. B. Knight, and Daniel SwernCite this: J. Am. Chem. Soc. 1952, 74, 19, 4886–4889Publication Date (Print):October 1, 1952Publication History Published online1 May 2002Published inissue 1 October 1952https://pubs.acs.org/doi/10.1021/ja01139a045https://doi.org/10.1021/ja01139a045research-articleACS PublicationsRequest reuse permissionsArticle Views57Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Foinaven and Schiehallion Developments (1996)

Abstract The UK Quad 204 sector between the Shetland Islands and the Fames presents many challenges to offshore oilfield developments. The waters are deep and the weather and currents are harsh. The reservoirs are relatively modest on a world scale and being shallow require multiple drill sites and extensive use of horizontal wells. This paper describes the phased, fast track, parallel approach adopted by BP to substantially reduce historical discovery to production times. The first project Foinaven uses an FPSO based on a substantially rebuilt Russian submarine carrier, with two subsea well clusters giving an annual production of 85mbd. The second Schiehallion project is larger at 142mbd and will use a much larger FPSO with multiple subsea well clusters. Both developments will use shuttle tankers for oil export. This paper summarises the technology employed on the two projects and the tendering strategy used to achieve the timetables set. Introduction The Faeroes/Shetland Trough area or the Atlantic frontier as it has become known, has some of the deepest waters in the British offshore territory. Environmental conditions in the area are challenging. While wind and wave conditions are similar to those experienced in the Northern North Sea the currents are significantly more severe and complex, almost down to the seabed, due to interaction between the warm Gulf Stream and cold Arctic Stream. Foinaven, the first development in the Atlantic Frontier area, is located in two blocks, 204/19 and 204124a, which are operated by BP Exploration with Shell UK Exploration and Production as co-venturer. These blocks lie some 180 kilometres west of the Shetland Islands, in a water depth of between 400 and 600 metres - See Fig. 1. This presents a formidable technical challenge, as it is too deep for divers, and any development has to rely heavily on subsea technology for unmanned intervention. Foinaven is based on the recovery of 200 million barrels. [t is designed to produce early oil efficiently, safely and at low cost. A fast track schedule has been adopted for the project execution plan. The development centres on subsea wells completed on the seabed, producing oil via a manifold, through rigid flowlines and then flexible risers into a floating production, storage and offloading system (FPSO) which will be permanently stationed in the field. Shuttle tankers will export the crude oil - See Fig. 2. The project was sanctioned late October 1994 with first oil targetted for summer 96. More information on the reservoir and environmental are given in ref 1-3. The second development in the area is Schiehallion located some 12km to the East of Foinaven. As with Foinaven, Schiehallion shares similar environmental challenges with respect to water depths, currents, wave heights and winds. Clearly, therefore the learning from Foinaven has been fundamental in the development of Schiehallion.
Agonists-antagonists derived from desomorphine and metopon (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAgonists-antagonists derived from desomorphine and metoponLewis J. Sargent and Everette L. MayCite this: J. Med. Chem. 1970, 13, 6, 1061–1063Publication Date (Print):November 1, 1970Publication History Published online1 May 2002Published inissue 1 November 1970https://pubs.acs.org/doi/10.1021/jm00300a009https://doi.org/10.1021/jm00300a009research-articleACS PublicationsRequest reuse permissionsArticle Views392Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Effect of Stoichiometry on the Dielectric Properties and Life Performance of (Pb <sub>0.875</sub> Ba <sub>0.125</sub> ) [(Mg <sub>1/3</sub> Nb <sub>2/3</sub> ) <sub>0.5</sub> (Zn <sub>1/3</sub> Nb <sub>2/3</sub> ) <sub>0.3</sub> Ti <sub>0.2</sub> ]O <sub>3</sub> Relaxor Dielectric Ceramic: Part I, Dielectric Properties (1993)

Effects of stoichiometry (A/B mole ratio, i.e., the ratio of elements on the A‐site to those on the B‐site in the perovskite structure) on the dielectric properties and microstructure of a partially A‐site substituted relaxor, (Pb 0.875 Ba 0.125 ) A [(Mg 1/3 Nb 2/3 ) 0.5 (Zn 1/3 Nb 2/3 ) 0.3 Ti 0.2 ] B O 3 were investigated in the A/B range between 0.95 and 1.05. Specimens, with A/B equal to or greater than 1.01, were sintered at lower temperatures than those with A/B equal to or less than 1.00. A maximum dielectric constant (K max ) value of 13300 was obtained when A/B was 1.01. When A/B was less than 1.01, K max decreased, due to the formation of pyrochlore phase. K max also decreased with A/B values greater than 1.01, probably due to a grain boundary phase. Resistivity measurements did not suggest a stoichiometry dependence. However, breakdown voltage decreased with an increase in A/B, possibly due to the segregation of PbO with low dielectric constant at grain boundaries.
Regulation of Lipid A Modifications by <i>Salmonella typhimurium</i> Virulence Genes <i>phoP-phoQ</i> (1997)

Bacterial pathogenesis requires proteins that sense host microenvironments and respond by regulating virulence gene transcription. For Salmonellae, one such regulatory system is PhoP-PhoQ, which regulates genes required for intracellular survival and resistance to cationic peptides. Analysis by mass spectrometry revealed that Salmonella typhimurium PhoP-PhoQ regulated structural modifications of lipid A, the host signaling portion of lipopolysaccharide (LPS), by the addition of aminoarabinose and 2-hydroxymyristate. Structurally modified lipid A altered LPS-mediated expression of the adhesion molecule E-selectin by endothelial cells and tumor necrosis factor-alpha expression by adherent monocytes. Thus, altered responses to environmentally induced lipid A structural modifications may represent a mechanism for bacteria to gain advantage within host tissues.