gebhart/patrepeval huggingface dataset:
Which immunological parameters are clinically essential to monitor IL-2 cancer immunotherapy? (1999)

The evaluation of the immunobiological changes occuring during IL-2 cancer immunotherapy is not only important to correlate them with the clinical response or to understand the immune mechanism involved in tumor growth control, but also to predict the efficacy of treatment itself. As far as the immune status of patients prior to therapy is concerned, the evidence of the activation of the inflammatory response correlates with resistance to IL-2. Therefore, the evidence of abnormally high pretreatment values of inflammatory response markers, including ESR, CRP, neopterin and SIL-2R, may predict a lack of IL-2 efficacy. In contrast, changes in inflammatory parameters during IL-2 administration have no prognostic significance. The evidence of elevated pretreatment levels of the immunosuppressive cytokine IL-10 has also an unfavourable prognostic significance. At the other side, the evidence of a marked increase in hemopoietic cells involved in tumor cell destruction, such as lymphocytes and eosinophils, as well as in blood levels of antitumor cytokines, such as IL-12, correlates with efficacy of IL-2 cancer immunotherapy. A better definition of the prognostic significance of immunoinflammatory markers will allow us to manipulate and improve host biological response during cancer immunotherapy with IL-2.
Towards efficient and accurate QoE reporting for emerging streaming services (2009)

With the advent of fast Internet capable of delivering media to subscribers, whether via wired or wireless connections, streaming services constantly increase, and will continue to increase, their shares of the services provided by telecom operators. In order to build a business based on these services, the quality the subscribers perceive has to be accurately measured. This paper proposes an improved method of monitoring various quality indicators of a service providing media data to user equipment. Compared to existing solutions, the proposed method is more accurate and cost-efficient in metrics measurement and reporting. The overheads (including traffic overhead and CPU/memory utilizations) are also significantly lowered.
Automatic fault detection and recovery in real time switched Ethernet networks (1999)

EtheReal is a real-time fast Ethernet switch architecture that provides bandwidth guarantees to distributed multimedia applications without OS or hardware modifications on the host machines. It implements true link-layer multicast, and offers a natural match to support network-layer QoS protocols such as RSVP. Because real-time performance guarantees fundamentally require state to be installed inside the network, link/switch failures could lead to significant disruption to the QoS promised to the user applications. This paper describes the fault detection and recovery mechanism supported by the EtheReal architecture, and reports on the performance measurements of the initial prototype implementation. The heart of EtheReal's fault detection and recovery mechanism is a fast spanning tree reconfiguration algorithm to reduce the total fault recovery time, and a delayed link inactivation scheme that allows real-time connections which are not affected by the failed links/switches to continue to exist, even though some of the links are marked as "blocked" in the new spanning tree topology. Measurements on the prototype show that the fault detection and recovery time on a network whose diameter is 10 hops are 220 ms and 31 ms, respectively. This combined delay corresponds to a minor jitter in real-time audio/video communication, and is a significant improvement over the standard IEEE 802.1d implementation, which takes on the order of 30 sec.
A new speaker verification spoofing countermeasure based on local binary patterns (2013)

This paper presents a new countermeasure for the protection of automatic speaker verification systems from spoofed, converted voice signals.The new countermeasure is based on the analysis of a sequence of acoustic feature vectors using Local Binary Patterns (LBPs).Compared to existing approaches the new countermeasure is less reliant on prior knowledge and affords robust protection from not only voice conversion, for which it is optimised, but also spoofing attacks from speech synthesis and artificial signals, all of which otherwise provoke significant increases in false acceptance.The work highlights the difficulty in detecting converted voice and also discusses the need for formal evaluations to develop new countermeasures which are less reliant on prior knowledge and thus more reflective of practical use cases.
<b>The design and implementation of a high‐fidelity Raman imaging microscope</b> (1996)

We describe a Raman imaging microscope that produces high‐fidelity, large format Raman images and Raman spectra from samples as small as 1 μm in size. Laser illumination is delivered to the object by means of an infinity corrected microscope objective, either by a galvanometer scanning system or a widefield fibre optic. Wavelength selection of Raman scattered emission is achieved by an acousto‐optic tunable filter (AOTF), which maintains image fidelity and provides either continuous or random wavelength selection. The collimated AOTF output is imaged first by a tube lens and then by a projection lens onto a cooled silicon CCD array. Instrument features, including factors that determine the system’s spatial and spectral resolution, and design considerations are discussed in detail. Images and spectra of test objects and samples that demonstrate the capability of this imaging spectrometer are presented. The potential of intrinsic chemical imaging is discussed in terms of its use in the analyses of a variety of chemical and biological samples.
Las relaciones entre la UE y Cuba en el marco de la apertura de Barack Obama y Raúl Castro (2015)

Bruselas (y no pocos gobiernos europeos, especialmente el espanol) han recibido con sorpresa el anuncio de Washington y La Habana de darle un giro espectacular a sus relaciones diplomaticas, tras anos de enfrentamientos y debil comunicacion directa institucional. Mientras los Estados miembros de la UE proseguian sus propios tratos con La Habana, la Comision Europea y el gobierno de Cuba habian asentido en discutir una agenda amplia que desembocaria en la firma de un Tratado de Cooperacion y en la eliminacion de la Posicion Comun impuesta por Bruselas al regimen castrista en 1996. 
Hasta ahora, el contexto en que se inscribian estos hechos estaba marcado por el diferendo entre EEUU y Cuba, la ejecucion de los detalles del embargo norteamericano (segun esta codificado por la Helms-Burton Act) y una cierta confluencia de percepcion entre los gobiernos europeos y norteamericano respecto a las carencias politicas del regimen. Si para Washington la existencia de un regimen de estricta disciplina marxista merecia la imposicion de condiciones drasticas para la eliminacion del embargo, para la UE y la mayoria de sus gobiernos primaba la comunicacion en el marco de la llamada “implicacion constructiva”. 
Esto no impedia a los Estados miembros de la UE mantener su relacion con Cuba segun sus especiales vinculos historicos, intereses economicos y diversas visiones acerca de derechos humanos. Despues de superar ciertas etapas de enfrentamientos, Bruselas decidio en 2014, tras una cuidadosa preparacion, poner en marcha un programa pragmatico que desembocara en un Acuerdo de Cooperacion similar al que la UE institucional tiene con todos los paises y bloques de America Latina y el Caribe. En ese contexto se produjo el anuncio de la intencion de normalizacion de relaciones entre EEUU y Cuba, lo que ha abierto la agenda europeo-cubana tanto en intensidad de contenido como de tempo. Este analisis ofrece un repaso de la evolucion de la relacion europeo-cubana y sopesa algunas especulaciones y alternativas en cuanto a las decisiones a tomar.
Non-linear modelling of the NE67383 MESFET (2002)

The allowance for non-linear effects in the design of high frequency circuits has so far been relegated to the empirical domain, or has required the use of very expensive software, or software developed within certain institutions and not commercially available. Recently a low cost package (C/NL) has been released for the analysis and optimisation of non-linear microwave circuits, making use of a personal computer. In this paper the authors report on an investigation of the usefulness and reliability of this program. They have measured the S-parameters of a MESFET over the range from 1 GHz to 10 GHz, and at a variety of bias values, and have tried using C/NL and other software to fit a model to these data. In C/NL use has been made of the non-linear model thus generated to predict the gain compression, intermodulation and harmonic distortion parameters. The results have been compared with measured parameters.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Techniques for multigigabit coherent optical transmission (1987)

It has been anticipated that the main roles for coherent optical techniques will be to provide increased capacity both for long-haul transmission and wide-band signal distribution. This could be achieved by the combination of high-data-rate transmission and fine-grain WDM. To this end, heterodyne detection experiments have recently been extended into the gigabit regime but difficulties not present at lower data rates have been encountered. This paper discusses a range of technical solutions to these problems, including broad-band receivers, homodyne detection, and phase diversity reception, and reviews their current status.
Hirability in the Wild: Analysis of Online Conversational Video Resumes (2016)

Online social media is changing the personnel recruitment process. Until now, resumes were among the most widely used tools for the screening of job applicants. The advent of inexpensive sensors combined with the success of online video platforms has enabled the introduction of a new type of resume. Video resumes are short video messages where job applicants present themselves to potential employers. Online video resumes represent an opportunity to study the formation of first impressions in an employment context at a scale never attempted before, and to our knowledge they have not been studied from a behavioral standpoint. We collected a dataset of 939 conversational English-speaking video resumes from YouTube. Annotations of demographics, skills, and first impressions were collected using the Amazon Mechanical Turk crowdsourcing platform. Basic demographics were then analyzed to understand the population who uses video resumes to find a job, and results showed that applicants mainly consisted of young people looking for internship and junior positions. We developed a computational framework for the prediction of organizational first impressions, where the inference and nonverbal cue extraction steps were fully automated. Results demonstrate automatic prediction of first impressions of up to 27% of the variance explained for extraversion, and up to 20% for social and communication skills.
Synthese von 2,3‐substituierten Chinazolon‐(4)‐derivaten mit Hilfe von Phosphoroxychlorid (1961)

Abstract Durch Erhitzen von N‐Acylanthranilsäuren mit primären Aminen lassen sich leicht, bequem und in guten Ausbeuten 2,3‐disubstituierte Chinazolon‐(4)‐derivate herstellen.
PREVENTION OF ACUTE LETHAL GRAFT-VERSUS-HOST DISEASE IN F1 HYBRID MICE BY PRETREATMENT OF THE GRAFT WITH ANTI-NK-1.1 AND COMPLEMENT (1992)

We studied the effect of depleting NK1.1+ cells from an allograft of lymph node and spleen cells on the outcome of GVH disease in the parent----F1-hybrid combination C57BL/6----(C57BL/6xDBA/2)F1. Four treatment groups were established: group I mice were transplanted with an unmodified graft from normal donors; group II mice were transplanted with an NK1.1-depleted graft that had been harvested from normal donors; group III mice received grafts from donors that had been injected with Poly I:C (100 micrograms i.p.) 18 hr prior to harvesting (These grafts were incubated with complement, but no antibody.); group IV mice were transplanted with depleted grafts harvested from donors that had received Poly I:C. Recipients in each group were monitored for splenomegaly, mitogen responsiveness, NK and CTL activity, histopathology, weight loss, and mortality. Results showed that recipients in all four groups developed splenomegaly and unresponsiveness to LPS, PHA, and Con A by day 12. Augmented host-derived NK activity and graft-derived antihost CTL activity was also demonstrated. Group IV showed little or no weight loss, minimal histopathological changes and a marked reduction in mortality. Recipients in all other groups developed features characteristic of GVH disease and exhibited a steady decline in body weight beginning by day 12. Mortality generally began on day 18 and reached 75-90% by day 60. We postulate that anti-NK1.1 depletes cells from the graft are intimately connected with the effector mechanism in acute GVH disease.
Single‐step purification and structural characterization of human interleukin‐6 produced in <i>Esherichia coli</i> From a T7 RNA polymerase expression vector (1991)

Human interleukin-6 or B-cell stimulatory factor-2 is a cytokine involved in acute phase and immune response. Cloning of cDNA for human interleukin-6 in the pT7.7 expression plasmid under the control of a bacteriophage T7 RNA polymerase promoter system allows rapid production of the cytokine in Escherichia coli. Upon cell induction with isopropyl thiogalactopyranoside, recombinant human interleukin-6 is overexpressed and forms insoluble inclusion bodies. Solubilization of the protein with 6 M guanidine hydrochloride and refolding in the presence of a reduction/oxidation system results in a quantitative recovery of recombinant human interleukin-6. This material is already 70% pure and can be further purified to homogeneity with a single passage over a weak anionic-exchange column. Extended structural characterization of the purified protein by electrospray mass spectrometry, automated Edman degradation and peptide mapping by high-pressure liquid chromatography/fast-atom-bombardment mass spectrometry demonstrates that recombinant human interleukin-6 is identical to the natural protein both in amino acid sequence and S-S bridge content. However, it contains a minor component accounting for about 20% of the entire translated protein which exhibits a Met-Ala dipeptide extension at the N-terminus. Purified recombinant human interleukin-6 is biologically active because it is able to induce at least 70-fold the human C-reactive promoter transfected in human hepatoma Hep 3B cells and is stable for several months in 10% glycerol at 4 degrees C. The expression system described in the present work has the main advantage of producing a high yield of recombinant human interleukin-6 (about 25 mg/l) combined with a very simple purification scheme.
Synthesis, Characterisation and Crystal Structure of a Co-crystal of Two Components: 1,2-bis(6-methylpyridin-2-yl)ethane-1,2-dione and 1-(pyridin-2-yl)-2-(6-methylpyridin-2-yl)ethane-1,2-dione (2007)

A condensation reaction of an equimolar ratio of 2-pyridinecarboxaldehyde and (6-methylpyridin-2-yl)methanol without a catalyst in a solvent-free reaction at 140°C was expected to yield 2-hydroxy-[1,2-bis(6-methylpyridin-2-yl)]ethan-1-one. FT-IR spectroscopy of the yellow-brown solid reaction product indicated the presence of a –CO–COH– group. The solid compound was treated with cyclohexane and green crystals were produced. The crystals were characterised by FT-IR, 1 H NMR, EI mass spectrometry and single-crystal X-ray diffraction. The molecular and crystal structure determined by single-crystal X-ray diffraction resolved one crystal showing two molecular components [C 13 H 10 N 2 O 2 and C 14 H 12 N 2 O 2 ] at a ratio of 60.4:39.6 [C 13.40 H 10.79 N 2 O 2 ]. Both compounds co-crystallise in the triclinic space group P-1, with a = 7.859(5), b = 8.021(14), c = 9.060(5) Å, α = 101.36(2)°, β = 90.06(3)°, γ = 90.92(3)°, V = 559.8(5) Å 3 , Z = 2. The compounds were 1,2-bis(6-methylpyridin-2-yl)ethane-1,2-dione and 1-(pyridin-2-yl)-2-(6-methylpyridin-2-yl)ethane-1,2-dione. These results are important because they confirm that condensation in a solvent- and catalyst-free reaction yielded precursors that were converted into α-diketone compounds by the action of solvent and oxygen.
Implementing a phase detection ring oscillator PUF on FPGA (2018)

This paper propose a novel phase detection ring oscillator (RO) physically unclonable function (PUF). The proposed architecture of RO PUF uses phase detection scheme to generate a random output of the PUF. It consists of small amount of RO cells while making a lot of challenge-response pairs comparing with a classical RO PUF, which makes it easy to adopt it in various IoT devices. Our PUF can be used in IoT devices to make automatic generation of a digital identifier, to protect security keys, or to prevent chip cloning. We implement the proposed PUF in FPGA. The proposed RO PUF shows a good performance in three performance metrics such as uniqueness, steadiness, and randomness. Finally, we compare our result with other RO PUFs.
Hypothermia and electromagnetic rewarming in the rhesus monkey. (1984)

Five male rhesus monkeys (Macaca mulatta) were subjected, under ketamine anesthesia, to repeated hypothermia treatments that produced an average rectal temperature of 28.3 degrees C. Following hypothermia induction, the subjects were rewarmed using either a ventrally applied surgical heating pad supplied with 35 degrees C water or a radio-frequency (RF) induction coil operating at 13.56 MHz with an average specific absorption rate (SAR) calculated to be approximately 5.5 W X kg-1. A special temperature probe, nonperturbing to RF, was used in the RF rewarming experiments. Control experiments were also conducted in which only ketamine was administered over a 3-h period. RF rewarming to 35 degrees C typically required only 50 min; whereas, an average of 137 min was required for heating-pad rewarming. Analyses of blood serum collected during and up to 48 h after hypothermia treatments showed elevations at 24 h in creatine phosphokinase (CPK), lactic dehydrogenase (LDH), and glutamic oxaloacetic transaminase (GOT), and these elevations were highest for the ketamine controls and lowest for the RF rewarming experiments. The subjects have been periodically examined since these experiments, and all appear to be in good health. It is concluded that the careful application of RF energy to the central core of the body can successfully be used for rewarming purposes, is more effective than externally applied rewarming techniques, and is potentially useful in remote locations.
CATHODOLUMINESCENCE FOR CaWO4:Nd LASER PUMPING (1964)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation J. W. Ogland, C. W. Baugh, W. E. Horn; CATHODOLUMINESCENCE FOR CaWO4:Nd LASER PUMPING. Appl. Phys. Lett. 1 April 1964; 4 (7): 133–134. https://doi.org/10.1063/1.1753997 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioApplied Physics Letters Search Advanced Search |Citation Search
Carbohydrate Thioacetals. I. Lead Tetraacetate Oxidation of D-Arabinose Derivatives (1952)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCarbohydrate Thioacetals. I. Lead Tetraacetate Oxidation of D-Arabinose DerivativesS. B. BakerCite this: J. Am. Chem. Soc. 1952, 74, 3, 827–828Publication Date (Print):February 1, 1952Publication History Published online1 May 2002Published inissue 1 February 1952https://doi.org/10.1021/ja01123a501RIGHTS & PERMISSIONSArticle Views169Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (311 KB) Get e-Alerts Get e-Alerts
Effect of surfactant Sb on carrier lifetime in GaInP epilayers (2002)

Samples of Ga0.52In0.48P grown on (001) GaAs with small amounts of surfactant Sb were investigated using time-resolved photoluminescence. All samples show a luminescence that may be fit to a two-stage exponential decay with a fast and a slow lifetime. For growth without Sb (Sb/III(v)=0), the sample shows a strong CuPtB ordering and a fast component lifetime of 7 ns. As the Sb concentration is increased, the degree of order is reduced, with a consequent increase in band gap energy. In the highest band gap material, produced at Sb/III(v)=0.016, the fast lifetime is 2.9 ns, an order of magnitude larger than published values for GaInP disordered by misorienting the substrate. Increasing the Sb further causes the band gap energy to decrease due to the onset of composition modulation. At Sb/III(v)=0.064, the fast component lifetime decreases to 0.79 ns. Samples grown with Sb/III(v)&gt;0.016 show a lifetime that depends on energy and is fit well by a model of localized excitons.
PHYSIOLOGICAL CHARACTERISTICS OF <i>SPIRULINA PLATENSIS</i> (CYANOBACTERIA) CULTURED AT ULTRAHIGH CELL DENSITIES<sup>1</sup> (1996)

ABSTRACT Photosynthetic activity and growth physiology of Spirulina platensis (Nordstedt) Geitler cultures maintained at ultrahigh cell densities (i.e. above 100 mg chlorophyll‐L −1 ) in a newly designed photobioreactor were investigated. Nitrogen (NaNO 3 ) in standard Zarouk medium was characterized as a major nutrient‐limiting factor in such cultures. The effect of ultrahigh cell density on photoinhibition of photosynthesis, as reflected by chlorophyll fluorescence and photosynthetic oxygen evolution, was studied: elevating the population density may arrest photoinhibition induced by high photon flux density, as well as low temperature. The relationship between incident irradiance and oxygen production rate was linear in situ for cultures at the optimal cell density, indicating that light limitation rather than light saturation or photoinhibition is the dominant condition outdoors in cultures of ultrahigh cell densities. In contrast with other reports, the extent of biomass loss at night due mainly to dark respiration was found to be relatively small when cell density was optimal, exerting only a minor effect on overall net productivity. Measurements of oxygen consumption at night revealed low rates of respiration, which may be explained by the low value of the volumetric mass transfer coefficient (K L a) of oxygen. Hence, reduced oxygen tension may play a role in preventing full expression of the respiratory potential in ultrahigh cell density cultures in which photoadaptive strategy may explain cell composition. Ultrahigh cell densities optimized with respect to the intensity of the light source, the length of the light path, and the extent of stirring represent the key for obtaining high output rates of cell mass and some natural products.