gebhart/patrepeval huggingface dataset:
Growth inhibition of human keratinocytes by MC903 (calcipotriol) is linked to dephosphorylation of retinoblastoma gene product (1995)

Abstract Aim This paper compares the effects of MC903 (calcipotriol) and 1,25‐dihydroxyvitamin D 3 [1,25(OH) 2 D 3 ; calcitriol] on differentiation and proliferation of normal human keratinocytes cultured in serum‐free medium. In order to understand the inhibitory mechanism of MC903, we examined its effect on cell cycle kinetics and the phosphorylation of retinoblastoma gene product (pRB), a tumor suppressor gene products, in normal human keratinocytes. Background The hormonally active form of vitamin D 3 , 1,25‐dihydroxy vitamin D 3 [1,25(OH) 2 D 3 ], regulates the differentiation and proliferation of epidermal keratinocytes in vitro. MC903 is a novel vitamin D 3 analogue which is at least 100 times less potent than 1,25(OH) 2 D 3 in its effects on calcium homeostasis. Methods We analyzed cell differentiation and cell cycle by flow cytometry using a FACScan, and pRB phosphorylation by Western blotting and densitometer. Results MC903 induced growth inhibition and differentiation of human keratinocytes. Cell cycle analysis demonstrated that 10 ‐6 M of MC903 induced cell cycle arrest in both G1/G0 (62.4 ± 0.7% versus 56.5 ± 1.7% in control, p < 0.01) and G2 + M (19.2 ± 0.3% versus 14.0 ± 0.9% in control, p < 0.01) phase. 10 ‐6 M of MC903 also increased the depnosphorylated pRB from 25% at 0 h to 84% at 48 h, as well as 1,25(OH) 2 D 3 . Conclusions Since pRB phosphorylation is supposed to be essential for the progression from G1 to S phase, the inhibition of pRB phosphorylation could be responsible for the G1/G0 growth arrest induced by MC903 in normal human keratinocytes.
Fitting a surface to 3-D points using an inflating balloon model (2002)

We address the problem of fitting a surface to a cloud of 3-D points, as obtained from a set of registered range images. Our approach is based on a dynamic balloon model represented using a triangulated mesh. The vertices in the mesh are linked to their neighboring vertices through springs to simulate the surface tension and to keep the shell smooth. Unlike other dynamic models proposed by previous researchers, our balloon model is purely driven by an applied inflation force towards the object surface from inside of the object, until all the triangles have reached the surface. We present results on simple as well as nonstar-shaped objects from real range images.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
(Ga,Mn)As: A new diluted magnetic semiconductor based on GaAs (1996)

A new GaAs-based diluted magnetic semiconductor, (Ga,Mn)As, was prepared by molecular beam epitaxy. The lattice constant of (Ga,Mn)As films was determined by x-ray diffraction and shown to increase with the increase of Mn composition, x. Well-aligned in-plane ferromagnetic order was observed by magnetization measurements. Magnetotransport measurements revealed the occurrence of anomalous Hall effect in the (Ga,Mn)As layer.
Synthesis, Properties, and Guest−Host Systems of Triphenylamine-Based Oligo(arylenevinylene)s:  Advanced Materials for LED Applications (1996)

The synthesis of triphenylamine-based oligo(arylenevinylene)s was accomplished by Pd-catalyzed one-pot coupling of styrenes and tris(4-bromophenylamine). These oligo(arylenevinylene)s are characterized by temperature-induced crystallization in bulk but are amorphous in guest−host systems with polysulfone from which high-quality films for optical applications were obtained. The photoluminescence spectra of the oligo(arylenevinylene)s differed significantly in different solvents as well as in different polymer hosts which is of interest for multicolored LEDs.
Sequence-Directed DNA Translocation by Purified FtsK (2005)

DNA translocases are molecular motors that move rapidly along DNA using adenosine triphosphate as the source of energy. We directly observed the movement of purified FtsK, an Escherichia coli translocase, on single DNA molecules. The protein moves at 5 kilobases per second and against forces up to 60 piconewtons, and locally reverses direction without dissociation. On three natural substrates, independent of its initial binding position, FtsK efficiently translocates over long distances to the terminal region of the E. coli chromosome, as it does in vivo. Our results imply that FtsK is a bidirectional motor that changes direction in response to short, asymmetric directing DNA sequences.
Big data-driven optimization for mobile networks toward 5G (2016)

Big data offers a plethora of opportunities to mobile network operators for improving quality of service. This article explores various means of integrating big data analytics with network optimization toward the objective of improving the user quality of experience. We first propose a framework of Big Data-Driven (BDD) mobile network optimization. We then present the characteristics of big data that are collected not only from user equipment but also from mobile networks. Moreover, several techniques in data collection and analytics are discussed from the viewpoint of network optimization. Certain user cases on the application of the proposed framework for improving network performance are also given in order to demonstrate the feasibility of the framework. With the integration of the emerging fifth generation (5G) mobile networks with big data analytics, the quality of our daily mobile life is expected to be tremendously enhanced.
Analysis and manipulation methods of geographic informations (2003)

Geographic-feature extraction methods based on a mesh data model, covering a wide range of features such as surface area, solid volume, slope features, and ridge valley features are proposed. These methods can be applied also for change analysis between multiterm models for a specific area. By analyzing two models measured in different time in the same area, some dynamic informations about the change during the period has been quantitatively and qualitatively obtained.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
IgE actions on <scp>CD</scp> 4 <sup>+</sup> T cells, mast cells, and macrophages participate in the pathogenesis of experimental abdominal aortic aneurysms (2014)

Immunoglobulin E (IgE) activates mast cells (MCs). It remains unknown whether IgE also activates other inflammatory cells, and contributes to the pathogenesis of abdominal aortic aneurysms (AAAs). This study demonstrates that CD4+ T cells express IgE receptor FcεR1, at much higher levels than do CD8+ T cells. IgE induces CD4+ T-cell production of IL6 and IFN-γ, but reduces their production of IL10. FcεR1 deficiency (Fcer1a-/-) protects apolipoprotein E-deficient (Apoe-/-) mice from angiotensin-II infusion-induced AAAs and reduces plasma IL6 levels. Adoptive transfer of CD4+ T cells (but not CD8+ T cells), MCs, and macrophages from Apoe-/- mice, but not those from Apoe-/- Fcer1a-/- mice, increases AAA size and plasma IL6 in Apoe-/- Fcer1a-/- recipient mice. Biweekly intravenous administration of an anti-IgE monoclonal antibody ablated plasma IgE and reduced AAAs in Apoe-/- mice. Patients with AAAs had significantly higher plasma IgE levels than those without AAAs. This study establishes an important role of IgE in AAA pathogenesis by activating CD4+ T cells, MCs, and macrophages and supports consideration of neutralizing plasma IgE in the therapeutics of human AAAs.
Improved Survivable Routing Algorithm in WDM Mesh Networks (2007)

We address the protection of single-link failure in WDM mesh networks and propose an improved algorithm named near optimal routing (NOR). With respect to previous algorithm, the advantage of NOR is to obtain near optimal solutions by re-routing the primary or backup paths. Simulation results are shown to be promising.
Inflammatory Pseudotumor in Temporal Area-A Case Report (2005)

Inflammatory pseudotumor is an uncommon benign tumor of unknown cause that occurs most commonly in the lung. It is extremely rare in the oral and maxillofacial region. We report a case of inflammatory pseudotumor, located over left temporalis muscle in a 27-year-old male patient who found a mass over left temporal region 2 months prior to seeking medical attention. It was a hard mass, 6×6×3 cm in size, which was not movable and with no tenderness. Incisional biopsy followed by pathology report revealed inflammatory pseudotumor. Wide excision of the tumor was performed 1 week later via the route of coronary incision. Mild depression of left temporal area and loss of the ability to elevate left eyebrow were found. Post-operative 30-month follow up showed no local recurrence of the tumor. Inflammatory pseudo- tumor occurs commonly in the lung, liver, kidney, and orbit, but may be seen in a wide variety of locations in both children and adults. Here, we present pathologic findings and management of our case and a review of the literature.
The effect of sound on office productivity (2011)

This article reports the results of a questionnaire survey examining the effects of sound on office productivity and assessing the relationship between changes in office productivity and noise sources as well as five environmental and office design factors, namely temperature, air quality, office layout, sound and lighting. The convenience sample for the survey comprised 259 office workers in 38 air-conditioned offices in Hong Kong. The subjects were requested to complete the questionnaires themselves. The results show that among the five environmental and office design factors examined, sound and temperature were the principal factors affecting office productivity. A strong and significant correlation was also found between changes in office productivity and sound, temperature and office layout. Participants were separated into low- and high-productivity groups using the mean productivity score of all participants as the cut-point. The three most annoying noise sources, including conversation, ringing phones and machines, differed little in mean annoyance scores for the low- and high-productivity participants, indicating that they had a significant negative impact on all participants. The results also indicate that low-productivity participants were easily influenced by noises such as background noise, closing doors, and human activity, as well as those coming from both inside and outside the office. Practical applications: This study evaluates the effects of sound and other environmental and office design factors on office productivity. It suggests that sound is a principal factor affecting office productivity in modern air-conditioned offices.
Gynocriticism (2016)

Gynocriticism is the study of women's writing. The term gynocritics was coined by Elaine Showalter in 1979 to refer to a form of feminist literary criticism that is concerned with women as writers. Gynocriticism established the historical study of women writers as a legitimate field of academic inquiry and developed to encompass a broad range of methodologies of reading women's writing.
Predictive Simulation of Process Windows for Powder Bed Fusion Additive Manufacturing: Influence of the Powder Bulk Density (2017)

The resulting properties of parts fabricated by powder bed fusion additive manufacturing processes are determined by their porosity, local composition, and microstructure. The objective of this work is to examine the influence of the stochastic powder bed on the process window for dense parts by means of numerical simulation. The investigations demonstrate the unique capability of simulating macroscopic domains in the range of millimeters with a mesoscopic approach, which resolves the powder bed and the hydrodynamics of the melt pool. A simulated process window reveals the influence of the stochastic powder layer. The numerical results are verified with an experimental process window for selective electron beam-melted Ti-6Al-4V. Furthermore, the influence of the powder bulk density is investigated numerically. The simulations predict an increase in porosity and surface roughness for samples produced with lower powder bulk densities. Due to its higher probability for unfavorable powder arrangements, the process stability is also decreased. This shrinks the actual parameter range in a process window for producing dense parts.
Determination of Four Closely Related Triaryl-<i>s</i>-Triazines by Infrared Spectrometry. (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of Four Closely Related Triaryl-s-Triazines by Infrared Spectrometry.R. D. Spencer and B. H. BeggsCite this: Anal. Chem. 1963, 35, 11, 1633–1636Publication Date (Print):October 1, 1963Publication History Published online1 May 2002Published inissue 1 October 1963https://pubs.acs.org/doi/10.1021/ac60204a026https://doi.org/10.1021/ac60204a026research-articleACS PublicationsRequest reuse permissionsArticle Views78Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Melt rheology of polypropylene containing small amounts of high molecular weight chain. I. Shear flow (2001)

Abstract Large enhancements of the melt strength of polypropylene (PP) were achieved by the introduction of high molecular weight polyethylene (PE) into PP. The viscoelastic properties of the high‐melt‐strength PP melts under shear flow were investigated. It was found that the rheological properties of the high‐melt‐strength PP were distinctly different from those of conventional PP. The elastic response at low frequencies was significantly enhanced in comparison with the conventional PP, implying a presence of a long relaxation time mode that was not revealed in conventional PP. In step‐shear measurements, the fast and slow relaxation processes that characterized the linear viscoelastic properties were observed also for nonlinear relaxation moduli. The dependence of the damping for the slow process of the high‐melt‐strength PP on shear strain was much weaker than that of the fast process. These rheological behaviors characterizing the long relaxation time mode were further enhanced with the increasing concentration of high molecular mass PE. The unusual shear rheological behaviors were discussed in view of the role of high molecular weight PE as a long relaxation time mode within PP. © 2001 John Wiley & Sons, Inc. J Polym Sci Part B: Polym Phys 39: 2692–2704, 2001
EFFECT OF BIOFLAVONOIDS QUERCETIN AND CURCUMIN ON ISCHEMIC RENAL INJURY (1998)

Quercetin and curcumin reduce ischemia-reperfusion injury and its inflammatory sequelae. The bioflavonoids hold promise as agents that can reduce immune and nonimmune renal injury, the key risk factors in chronic graft loss.
Equilibrium and kinetic studies of lanthanide complexes of macrocyclic polyamino carboxylates (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEquilibrium and kinetic studies of lanthanide complexes of macrocyclic polyamino carboxylatesKrishan Kumar, C. Allen Chang, and M. F. TweedleCite this: Inorg. Chem. 1993, 32, 5, 587–593Publication Date (Print):March 1, 1993Publication History Published online1 May 2002Published inissue 1 March 1993https://doi.org/10.1021/ic00057a017Request reuse permissionsArticle Views808Altmetric-Citations141LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (799 KB) Get e-Alertsclose Get e-Alerts
Temporal Specificity in the Cortical Plasticity of Visual Space Representation (2002)

The circuitry and function of mammalian visual cortex are shaped by patterns of visual stimuli, a plasticity likely mediated by synaptic modifications. In the adult cat, asynchronous visual stimuli in two adjacent retinal regions controlled the relative spike timing of two groups of cortical neurons with high precision. This asynchronous pairing induced rapid modifications of intracortical connections and shifts in receptive fields. These changes depended on the temporal order and interval between visual stimuli in a manner consistent with spike timing-dependent synaptic plasticity. Parallel to the cortical modifications found in the cat, such asynchronous visual stimuli also induced shifts in human spatial perception.
The role of prostate specific antigen measurement in the detection and management of prostate cancer. (2000)

The introduction of prostate specific antigen (PSA) testing has revolutionised the early detection, management and follow-up of patients with prostate cancer and it is considered to be one of the best biomedical markers currently available in the field of oncology. Its use with annual digital rectal examination in prostate cancer screening programmes has led to a marked change in the distribution of stage at presentation towards earlier disease and led to a significant increase in the detection of potentially curable disease. In order to improve the specificity of PSA testing and thereby reduce the number of unnecessary prostatic biopsies, a number of refinements of PSA evaluation have been proposed. These include free to total PSA ratio, PSA density, PSA density, PSA density of the transition zone, PSA velocity and age-specific PSA reference ranges. The utility of these approaches is considered in this review. The role of PSA monitoring in the detection of recurrence following radical prostatectomy and radiotherapy is discussed, as well as its role in monitoring patients treated with endocrine therapy is discussed, as well as its role in monitoring patients treated with endocrine therapy in terms of correlating PSA response with outcome, in detecting disease progression and in guiding the use of subsequent therapies. Large continuing multicentre screening and outcome studies will provide important information enabling greater refinement of the use of this important diagnostic and monitoring tool in the future detection and management of prostate cancer.
Embryology of the endocrine heart (1989)

Recent interest in the storage, release, and action of atrial natriuretic peptide (ANP) in adult mammals has directed our attention to the early appearance, distribution, and possible function of this cardiac hormone during embryonic development. This report summarizes efforts to map and quantify cardiac ANP in developing and neonatal rats, rabbits, and pigs. Levels of ANP immunoreactivity in fetal and neonatal hearts were measured by radioimmunoassay of atrial and ventricular homogenates. Histochemical localization of ANP deposits was accomplished by immunoperoxidase staining of paraffin embedded tissues. The antibodies used were raised in rabbits or guinea pigs against purified rat pro-ANP or synthetic fragments of porcine pro-ANP. In series of rat and rabbit hearts spanning the period from cardiac septation (gestational day 15) to birth, RIA-detectable ANP levels in atrial homogenates rose steadily to maximum values near birth. In ventricular homogenates, lower levels of ANP immunoreactivity declined gradually throughout the embryonic and neonatal period from highest levels in the early embryonic period toward extremely low levels in the adult. During the morphogenetic period of cardiac septation, ANP immunoreactivity intensified within the inner layers of atrial myocardium and along ventricular trabeculae in apparent association with the coalescing cardiac conducting system, especially apparent in the embryonic pig.
ASSESSMENT OF THE ANTITUMOUR ACTIVITY OF TARGETED IMMUNOSPECIFIC ALBUMIN MICROSPHERES LOADED WITH CISPLATIN AND 5‐FLUOROURACIL: TOXICITY AGAINST A RODENT OVARIAN CARCINOMA <i>IN VITRO</i> (2001)

The 3-(4,5 dimethylthiazol-2-yl)-2,5 diphenyltetrazolium bromide (MTT) assay is used successfully to estimate the number of viable cells in drug screening trials. We used the MTT assay to assess the viability of a rodent ovarian carcinoma cell line (DMBA-OC-1R) after exposure to combinations of cisplatin and 5-fluorouracil as free drug and in encapsulated (conjugated and unconjugated) forms. After 48 h of exposure to free drugs, a significant trend towards cell cytotoxicity could be observed and this was well established by 120 h. Cells treated with drug-containing immuno-microspheres showed a similar initial decrease in cell viability after 96 h, and this was maintained for 128 h. These results suggest that immuno-microspheres loaded with chemotherapeutic drugs have the potential to be successfully used in the treatment of ovarian cancer.
Using an IEEE 802.1AS network as a distributed IEEE 1588 boundary, ordinary, or transparent clock (2010)

IEEE 802.1AS includes a very specific profile of IEEE 1588 that only runs at layer 2 over networks that follow the IEEE 802 architecture. It has some significant performance and scalability advantages, but at the cost of not allowing non-PTP-aware devices. This paper describes how a network having a common source of time can act as a distributed IEEE 1588 boundary, ordinary, or transparent clock, allowing the network to transport synchronization between portions of an IEEE 1588 network domain, and do this for any number of domains simultaneously. The network that acts as a distributed clock can be a PTP network supporting a profile that is different from that of the domains whose timing it is transporting. As one example, an IEEE 802.1AS network can act as a distributed IEEE 1588 boundary, ordinary, or transparent clock. As part of the discussion, the paper also shows that an IEEE 1588 boundary clock and peer-to-peer transparent clock are functionally equivalent in the manner in which they transport synchronization, and that the principal difference between the two is that the former invokes a best master clock algorithm (either default or alternate) and implements the full PTP state machine, while the latter does not. The concepts of distributed BC, TC, and OC, and the equivalence of the BC and peer-to-peer TC may be considered a new way of looking at the transport of synchronization in a network based on IEEE 1588.