gebhart/patrepeval huggingface dataset:
1,6-Diammonium-2,4-hexadiyne analogs of hexamethonium (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT1,6-Diammonium-2,4-hexadiyne analogs of hexamethoniumJoseph G. Cannon, Lester E. Johnson, John Paul Long, and Sharon HeintzCite this: J. Med. Chem. 1974, 17, 3, 355–358Publication Date (Print):March 1, 1974Publication History Published online1 May 2002Published inissue 1 March 1974https://pubs.acs.org/doi/10.1021/jm00249a022https://doi.org/10.1021/jm00249a022research-articleACS PublicationsRequest reuse permissionsArticle Views79Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
EasyConvPooling: Random Pooling with Easy Convolution for Accelerating Training and Testing (2018)

Convolution operations dominate the overall execution time of Convolutional Neural Networks (CNNs). This paper proposes an easy yet efficient technique for both Convolutional Neural Network training and testing. The conventional convolution and pooling operations are replaced by Easy Convolution and Random Pooling (ECP). In ECP, we randomly select one pixel out of four and only conduct convolution operations of the selected pixel. As a result, only a quarter of the conventional convolution computations are needed. Experiments demonstrate that the proposed EasyConvPooling can achieve 1.45x speedup on training time and 1.64x on testing time. What's more, a speedup of 5.09x on pure Easy Convolution operations is obtained compared to conventional convolution operations.
Potent Antiarrhythmic Effects of Chronic Amiodarone in Canine Pulmonary Vein Sleeve Preparations (2009)

The results point to potent effects of chronic amiodarone to preferentially suppress arrhythmogenic substrates and triggers arising from the PV sleeves of the dog.
A fitness game reflecting heart rate (2006)

Lack of exercise is known to be detrimental to health, and various exercise machines that can be used indoors in a convenient manner are available. However, because expertise is required to ascertain which exercise to do and for how long, people sometimes sustain injuries by exercising excessively and find it difficult to sufficiently benefit from exercising. Therefore, fitness machines with automatic controls are being developed so that people can exercise efficiently, and exercise programs are being designed with game elements to encourage regular exercise. Monotonous exercise makes it difficult for people to experience a sense of accomplishment while exercising, and if the degree of difficulty is not set properly, people cannot perform the appropriate amount of exercise. The present study proposes a fitness game method in which heart rate is measured in real time while playing a game and the contents of the game are actively adjusted based on heart rate, thus allowing users to perform sufficient amounts of exercise and experience a sense of accomplishment. A fitness game based on boxercise movements was designed based on the present method and then evaluated.
Ischemic Preconditioning in the Intact Rat Heart Is Mediated by δ<sub>1</sub>- But Not μ- or κ-Opioid Receptors (1998)

These results indicate that delta1-opioid receptors play an important role in the cardioprotective effect of ischemic preconditioning in the rat heart.
An Origami-Structured Flexible Electronic Substrate with Faces Parallel to Target-of-Attachment Surfaces (2020)

We propose a flexible electronic substrate structured by Origami folding of non-stretchable film with faces parallel to target-of-attachment surfaces. A folding (“Origami”) or cutting (“Kirigami”) of a thin film have opened up the application of non-stretchable materials to flexible electronic devices attached to a curved surface. In this paper, we propose origami-structured flexible electronic substrates which have faces parallel to the target-of-attachment surface. The parallel faces have engineering importance and usefulness for taking direct contact with target-of-attachment surfaces and mounting electronic elements, e.g. sensors or light emitters. These characteristics are expected to allow for the realization of flexible devices capable of sensing shear force or flow velocity parallel to object's surfaces.
Endoplasmic Reticulum Stress and Oxidative Stress in Cell Fate Decision and Human Disease (2014)

A greater fundamental understanding of the mechanisms that preserve protein folding homeostasis and redox status will provide new information toward the development of novel therapeutics for many human diseases.
Early steps in bone resorption in experimental periodontitis: a histomorphometric study. (1993)

A histomorphometric study of the initial steps in the process of bone resorption of inflammatory origin is presented. The study was performed in a model of experimental periodontitis, in which plaque formation is induced by means of a cotton thread ligature placed around the neck of the first molar of Wistar rats. The treated animals were killed in groups after 24, 48, 72 and 96 hours. An equivalent number of untreated rats were employed as controls. After routine histologic processing mesiodistal sections were obtained. The histologic studies showed the sequence of events of the inflammatory process and bone resorption. The histomorphometric studies showed the concomitant increase in erosive areas and number of osteoclasts with the highest values at 72 hours. At 96 hours both parameters decreased. The results are discussed in the light of those afforded by other experimental models, in which bone resorption is induced by orthodontic forces. In these models the increase in the resorptive areas precedes the increase in the number of osteoclasts. The existence of two different mechanisms for the initiation of bone resorption, one which involves the action of an inflammatory environment and the other which results from the action of mechanical forces, is proposed.
Spinodal copper alloy C72900 – new high strength antifriction alloy system (2011)

Copper–15 nickel–8 tin alloy is a relatively modern material, having been discovered in the 1970s. It has complexities with casting, hot working and interdependent solid state phase transformations. A key to the high reliability manufacture of wrought rods, bars, plates and tubes is the casting technology, which limits segregation, promotes microstructural uniformity and enables hot working. The EquaCast continuous casting process has enabled the production of a broadening variety of wrought forms with typical yield strengths ranging from 100 000 to 180 000 lb in−2 (690 to 1241 MPa) depending on size, shape and temper. This paper reviews the characteristics of wrought copper–15 nickel–8 tin products which have registration in AMS specifications (4596 and 4597) and MMPDS-04 (CN-1) for use in aircraft. The design limits, microstructures, fracture characteristics and tribological behaviour will be examined. This alloy system is emerging as a material of choice for aircraft bearings, corrosion resistant oil and gas exploration components, machinery and demanding off-road equipment applications. ToughMet 3 is an alternative or upgrade to conventional moderate and high strength aluminium bronze bearing alloys.L’alliage de cuivre-15 nickel-8 étain est un matériau relativement moderne qui a été découvert dans les 1970’s. Il a un degré de complexité avec le moulage, le travail à chaud et des transformations de phase interdépendantes à l’état solide. Un point clé de la fiabilité élevée lors de la fabrication des tiges, des barres, des tôles et des tubes corroyés, réside dans sa technologie de moulage, laquelle limite la ségrégation, favorise l’uniformité de la microstructure et rend possible le travail à chaud. Le processus EquaCastÒ de coulée continue a rendu possible la production d’une variété de plus en plus grande de formes corroyées, avec des limites élastiques typiques allant de 100 à 180 ksi (690 à 1241 MPa), dépendant de la taille, de la forme et du revenu. Cet article examine les caractéristiques des produits corroyés de cuivre-15 nickel-8 étain qui sont enregistrés dans les spécifications d’AMS (4596 et 4597) et de MMPDS-04 (CN-1) pour utilisation dans l’aviation. On examine les limites de concept, les microstructures, les caractéristiques de fracture et le comportement tribologique. Ce système d’alliage émerge comme matériau de choix pour les roulements d’avion, pour les composantes résistantes à la corrosion pour l’exploration de l’huile et du gaz, pour la machinerie et pour les applications exigeantes d’équipement tout-terrain. ToughMetÒ 3 est une solution de rechange ou une version améliorée des alliages conventionnels de roulement de bronze d’aluminium à résistance modérée ou élevée.
Modeling Coal Seam Damage in Cast Blasting (1998)

A discrete element computer program named DMC_BLAST (Distinct Motion Code) has been under development since 1987 for modeling rock blasting (Preece & Taylor, 1989). This program employs explicit time integration and uses spherical or cylindrical elements that are represented as circles in two dimensions. DMC_BLAST calculations compare favorably with data from actual bench blasts (Preece et al, 1993). Coal seam chilling refers to the shattering of a significant portion of the coal leaving unusable fines. It is also refereed to as coal damage. Chilling is caused during a blast by a combination of explosive shock energy and movement of the adjacent rock. Chilling can be minimized by leaving a buffer zone between the bottom of the blastholes and the coal seam or by changing the blast design to decrease the powder factor or by a combination of both. Blast design in coal mine cast blasting is usually a compromise between coal damage and rock fragmentation and movement (heave). In this paper the damage to coal seams from rock movement is examined using the discrete element computer code DMC_BLAST. A rock material strength option has been incorporated into DMC_BLAST by placing bonds/links between the spherical particles used to model the rock. These bonds tie the particles together but can be broken when the tensile, compressive or shear stress in the bond exceeds the defined strength. This capability has been applied to predict coal seam damage, particularly at the toe of a cast blast where drag forces exerted by movement of the overlying rock can adversely effect the top of the coal at the bench face. A simulation of coal mine cast blasting has been performed with special attention being paid to the strength of the coal and its behavior at t he bench face during movement of the overlying material.
Extensions to OSPF to Support Mobile Ad Hoc Networking (2010)

This document describes extensions to OSPF to support mobile ad hoc networks (MANETs). The extensions, called OSPF-OR (OSPF-Overlapping Relay), include mechanisms for link-local signaling (LLS), an OSPF-MANET interface, a simple technique to reduce the size of Hello packets by only transmitting incremental state changes, and a method for optimized flooding of routing updates. OSPF-OR also provides a means to reduce unnecessary adjacencies to support larger MANETs. Status of This Memo This document is not an Internet Standards Track specification; it is published for examination, experimental implementation, and evaluation. This document defines an Experimental Protocol for the Internet community. This document is a product of the Internet Engineering Task Force (IETF). It represents the consensus of the IETF community. It has received public review and has been approved for publication by the Internet Engineering Steering Group (IESG). Not all documents approved by the IESG are a candidate for any level of Internet Standard; see Section 2 of RFC 5741. Information about the current status of this document, any errata, and how to provide feedback on it may be obtained at
Hormone replacement therapy in systemic lupus erythematosus. (1997)

The use of HRT in postmenopausal women with SLE does not appear to increase the rate of lupus flares over a one year followup.
Origami‐Based Reconfigurable Metamaterials for Tunable Chirality (2017)

Origami is the art of folding two-dimensional (2D) materials, such as a flat sheet of paper, into complex and elaborate three-dimensional (3D) objects. This study reports origami-based metamaterials whose electromagnetic responses are dynamically controllable via switching the folding state of Miura-ori split-ring resonators. The deformation of the Miura-ori unit along the third dimension induces net electric and magnetic dipoles of split-ring resonators parallel or anti-parallel to each other, leading to the strong chiral responses. Circular dichroism as high as 0.6 is experimentally observed while the chirality switching is realized by controlling the deformation direction and kinematics. In addition, the relative density of the origami metamaterials can be dramatically reduced to only 2% of that of the unfolded structure. These results open a new avenue toward lightweight, reconfigurable, and deployable metadevices with simultaneously customized electromagnetic and mechanical properties.
Unusual Growth of InP Nanowires Grown on Silicon Surfaces (2006)

Heteroepitaxial growth of III-V compound semiconductors on Si would enable the integration of high speed optoelectronic devices with mature Si technology. We report the growth of single-crystalline InP nanowires on
Efficient System of Artificial Oil Bodies for Functional Expression and Purification of Recombinant Nattokinase in <i>Escherichia coli</i> (2005)

Nattokinase, a serine protease, and pronattokinase, when expressed in Escherichia coli, formed insoluble aggregates without enzymatic activity. For functional expression and purification, nattokinase or pronattokinase was first overexpressed in E. coli as an insoluble recombinant protein linked to the C terminus of oleosin, a structural protein of seed oil bodies, by an intein fragment. Artificial oil bodies were reconstituted with triacylglycerol, phospholipid, and the insoluble recombinant protein thus formed. Soluble nattokinase was subsequently released through self-splicing of intein induced by temperature alteration, with the remaining oleosin-intein residing in oil bodies and the leading propeptide of pronattokinase, when present, spontaneously cleaved in the process. Active nattokinase with fibrinolytic activity was harvested by concentrating the supernatant. Nattokinase released from oleosin-intein-pronattokinase exhibited 5 times higher activity than that released from oleosin-intein-nattokinase, although the production yields were similar in both cases. Furthermore, active nattokinase could be harvested in the same system by fusing pronattokinase to the N terminus of oleosin via a different intein linker, with self-splicing induced by 1,4-dithiothreitol. These results have shown a great potential of this system for bacterial expression and purification of functional recombinant proteins.
Anomalous Dispersion in the Infrared* (1962)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Norman E. Sharpless and Dolores A. Gregory, "Anomalous Dispersion in the Infrared*," J. Opt. Soc. Am. 52, 579-579 (1962) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Multiple mechanisms for the activation of human platelet aggregation by <i>Staphylococcus aureus</i>: roles for the clumping factors ClfA and ClfB, the serine–aspartate repeat protein SdrE and protein A (2002)

The ability of Staphylococcus aureus cells to induce platelet aggregation has long been recognized. However, despite several attempts to identify the mechanisms involved in this interaction, the nature of the bacterial receptors required remains poorly understood. Using genetic manipulation, this study for the first time provides clear evidence that several S. aureus surface proteins participate in the inter-action with platelets. Mutants of S. aureus strain Newman lacking one or more surface proteins were tested for their ability to stimulate platelet aggregation. This approach was complemented by the expression of a number of candidate proteins in the non-aggregating Gram-positive bacterium Lacto-coccus lactis. S. aureus-induced aggregation was monophasic and was dependent on the platelet receptor GPIIb/IIIa. The fibrinogen-binding proteins, clumping factors A and B and the serine-aspartate repeat protein SdrE could each induce aggregation when expressed in L. lactis. Although protein A expressed in L. lactis was not capable of inducing aggregation independently, it enhanced the aggregation response when expressed on the surface of S. aureus. Thus, S. aureus has multiple mechanisms for stimulating platelet aggregation. Such functional redundancy suggests that this phenomenon may be important in the pathogenesis of invasive diseases such as infective endocarditis.
How important are climate characteristics to the estimation of rice production function? (2012)

Considerable attention has been given to the impact of climate variability on farm production, and most of the researches have been provided by agronomists to identify the bio-physical relationship between climatic factors and crop production. Relatively, little attention has been given to this relationship from the standpoint of agricultural economists. This study aims to fill this void by assessing the potential cost of ignoring the impact of weather variability on the estimation of rice production function. Using nationwide representative farm-level data in Taiwan in 2008 and the Geographic Information System method, we merged the appropriate weather data with the existing farm data. Our results point to a biased estimation of the input elasticities if weather conditions are not considered. Moreover, the effects of temperature on rice production are more pronounced than the effects of rainfall.

	 

	Key words: Climate variability, farm production function, input elasticities, rice, Taiwan.
<i>C</i>-Branched Iminosugars: α-Glucosidase Inhibition by Enantiomers of isoDMDP, isoDGDP, and isoDAB–<scp>l</scp>-isoDMDP Compared to Miglitol and Miglustat (2013)

The Ho crossed aldol condensation provides access to a series of carbon branched iminosugars as exemplified by the synthesis of enantiomeric pairs of isoDMDP, isoDGDP, and isoDAB, allowing comparison of their biological activities with three linear isomeric natural products DMDP, DGDP, and DAB and their enantiomers. L-IsoDMDP [(2S,3S,4R)-2,4-bis(hydroxymethyl)pyrrolidine-3,4-diol], prepared in 11 steps in an overall yield of 45% from d-lyxonolactone, is a potent specific competitive inhibitor of gut disaccharidases [K(i) 0.081 μM for rat intestinal maltase] and is more effective in the suppression of hyperglycaemia in a maltose loading test than miglitol, a drug presently used in the treatment of late onset diabetes. The partial rescue of the defective F508del-CFTR function in CF-KM4 cells by L-isoDMDP is compared with miglustat and isoLAB in an approach to the treatment of cystic fibrosis.
Particle Emissions from Light-Duty Vehicles during Cold-Cold Start (2016)

<div class="section abstract"><div class="htmlview paragraph">To ensure reliable starting under cold weather conditions (&lt; 0 <sup>o</sup>C ambient), gasoline engines use fuel enrichment, leading to higher soot formation and greater tailpipe particle number (PN) emissions. In gasoline direct injection (GDI) engines, PN emissions are higher due to liquid fuel impingement on cold surfaces of the combustion chamber and piston. This study characterizes solid (mostly elemental carbon) and semi-volatile (organic) particle number, mass, and size distributions during cold-cold engine start-up from light duty vehicles. Particle emissions were sampled from vehicles upon engine start-up after an overnight soak, with an average ambient temperature of -8 ± 7 <sup>o</sup>C. The average PN emitted during 180 seconds by GDI and PFI vehicles were 3.09E+13 and 2.12E+13 particles respectively. Comparing to 2017 Euro 6 New European Driving Cycle (NEDC) limit on cumulative particles emitted over the entire test cycle, most PFI and GDI vehicles exceeded this limit in 6-12 seconds after a cold-cold start. In addition, EPA Tier 3 particle mass requirements are exceeded for tested GDI vehicles due to their characteristically high concentration of accumulation mode particles. In comparison, diesel vehicles with DPF’s were the cleanest, with particle concentrations close to background levels. Cold-cold starts were followed by a five-minute soak and a second engine start. GDI vehicles’ total emitted PN was almost two to three times that of PFI vehicles during restart. This study highlights the need for better particle control strategies to reduce particle emissions during engine start-up in cold ambient temperatures. Our work also confirms that under cold-cold start conditions, most of the total exhaust particles are solid soot and only a small fraction are semi-volatile.</div></div>
Gene Therapy for Parkinsons Disease: Progress and Challenges (2005)

Therapy for Parkinson's disease (PD), a common neurological disorder characterized by pathological degeneration of the nigrostriatal dopaminergic system, remains unsatisfactory. Gene therapy is considered one of the most promising approaches to developing a novel effective treatment for PD. Among the numerous candidate genes that have been tested as therapeutic agents, those encoding tyrosine hydroxylase, guanosine triphosphate cyclohydrolase I and aromatic L-amino acid decarboxylase all boost dopamine production, while glial cell line-derived neurotrophic factor promotes the survival of dopaminergic neurons and is generally believed to possess the greatest potential for successful restoration of the dopaminergic system. The genes encoding vesicular monoamine transporter-2 and glutamic acid decarboxylase have also produced therapeutic effects in animal models of PD. Both viral and non-viral vectors, each with its particular advantages and disadvantages, have been used to deliver these genes into the brain. Whether or not regulatable expression systems are essential to successful gene therapy for PD remains a critical issue in the clinical application of this emerging treatment. Here we review the current status of gene therapy for PD, including the application of control systems for transgene expression in the brain.