gebhart/patrepeval huggingface dataset:
The miR-193a-3p-regulated ING5 gene activates the DNA damage response pathway and inhibits multi-chemoresistance in bladder cancer (2015)

As the major barrier to curative cancer chemotherapy, chemoresistance presents a formidable challenge to both cancer researchers and clinicians. We have previously shown that the bladder cancer (BCa) cell line 5637 is significantly more sensitive to the cytoxicity of five chemotherapeutic agents than H-bc cells. Using an RNA-seq-based omic analysis and validation at both the mRNA and protein levels, we found that the inhibitor of growth 5 (ING5) gene was upregulated in 5637 cells compared with H-bc cells, indicating that it has an inhibitory role in BCa chemoresistance. siRNA-mediated inhibition of ING5 increased the chemoresistance and inhibited the DNA damage response pathway in 5637 cells. Conversely, forced expression of EGFP-ING5 decreased the chemoresistance of and activated the DNA damage response pathway in H-bc cells. We also showed that ING5 gene expression is inhibited by miR-193a-3p and is instrumental in miR-193a-3p's role in activating BCa chemoresistance. Our results demonstrate both the role and mechanism of inhibition of BCa chemoresistance by ING5.
Numerical simulations of Hall-effect plasma accelerators on a magnetic-field-aligned mesh (2012)

The ionized gas in Hall-effect plasma accelerators spans a wide range of spatial and temporal scales, and exhibits diverse physics some of which remain elusive even after decades of research. Inside the acceleration channel a quasiradial applied magnetic field impedes the current of electrons perpendicular to it in favor of a significant component in the E×B direction. Ions are unmagnetized and, arguably, of wide collisional mean free paths. Collisions between the atomic species are rare. This paper reports on a computational approach that solves numerically the 2D axisymmetric vector form of Ohm's law with no assumptions regarding the resistance to classical electron transport in the parallel relative to the perpendicular direction. The numerical challenges related to the large disparity of the transport coefficients in the two directions are met by solving the equations on a computational mesh that is aligned with the applied magnetic field. This approach allows for a large physical domain that extends more than five times the thruster channel length in the axial direction and encompasses the cathode boundary where the lines of force can become nonisothermal. It also allows for the self-consistent solution of the plasma conservation laws near the anode boundary, and for simulations in accelerators with complex magnetic field topologies. Ions are treated as an isothermal, cold (relative to the electrons) fluid, accounting for the ion drag in the momentum equation due to ion-neutral (charge-exchange) and ion-ion collisions. The density of the atomic species is determined using an algorithm that eliminates the statistical noise associated with discrete-particle methods. Numerical simulations are presented that illustrate the impact of the above-mentioned features on our understanding of the plasma in these accelerators.
Analysis of Messy Data, Volume II (2017)

Researchers often do not analyze nonreplicated experiments statistically because they are unfamiliar with existing statistical methods that may be applicable. Analysis of Messy Data, Volume II details the statistical methods appropriate for nonreplicated experiments and explores ways to use statistical software to make the required computations feasible.
Backpropagation Algorithms for a Broad Class of Dynamic Networks (2007)

This paper introduces a general framework for describing dynamic neural networks--the layered digital dynamic network (LDDN). This framework allows the development of two general algorithms for computing the gradients and Jacobians for these dynamic networks: backpropagation-through-time (BPTT) and real-time recurrent learning (RTRL). The structure of the LDDN framework enables an efficient implementation of both algorithms for arbitrary dynamic networks. This paper demonstrates that the BPTT algorithm is more efficient for gradient calculations, but the RTRL algorithm is more efficient for Jacobian calculations.
A Modification of the Glees Silver Impregnation for Normal and Degenerating Nervous Tissue (1974)

A modification of the Glees method for silver impregnation of normal and degenerating nervous tissue is described. It offen geat reliability, evenness of impregnation and since it can be used on batches of slides, is also suitable for histology dass material. The results are illustrated. The procedure for paraffin sections of formalin-Iixed material is as follows: dewaxed and celloidin coated sections are left in 20% silver nitrate solution for 2 hr or until light brown. They are then treated successively in Nauta reducing agent (400 ml distilled water, 45 ml 96% ethanol, 13.5 ml 10% formalin, 13.5 ml 1% acetic acid)—10 min, ammoniacal 5% silver nitrate solution in 80% ethanol (5 g AgNO8 are dissolved in 100 ml 80% ethanol and 25% ammonia solution is added drop by drop until the precipitate clears)—15 min, rinse in absolute ethanol—10 sec. Reduce in two changes of reducing solution (400 ml 10% formalin, 50 ml 96% ethanol, 20 d 1% aretic acid)—10 min, rinse in tap water, fix in 5% sodium thiosulphate—3 min, rinse in tap water, dehydrate sections, remove celloidin, and mount in DePeX.The ammoniacal silver nitrate solution must be freshly prepared before use.The importance and use of the various additives to the solutions are discussed and suggestions are made to enable users to alter the character of the impregnation to suit special purposes.
Natural Language Grammar Induction using a Constituent-Context Model (2002)

This paper presents a novel approach to the unsupervised learning of syntactic analyses of natural language text.Most previous work has focused on maximizing likelihood according to generative PCFG models.In contrast, we employ a simpler probabilistic model over trees based directly on constituent identity and linear context, and use an EM-like iterative procedure to induce structure.This method produces much higher quality analyses, giving the best published results on the ATIS dataset.
A 4.4 ns CMOS 54×54-b multiplier using pass-transistor multiplexer (1995)

A 54/spl times/54-b multiplier using pass-transistor multiplexers has been fabricated by 0.25 /spl mu/m CMOS technology. To enhance the speed performance, a new 4-2 compressor and a carry lookahead adder (CLA), both featuring pass-transistor multiplexers, have been developed. The new circuits have a speed advantage over conventional CMOS circuits because the number of critical-path gate stages is minimized due to the high logic functionality of pass-transistor multiplexers. The active size of the 54/spl times/54-b multiplier is 3.77/spl times/3.41 mm. The multiplication time is 4.4 ns at a 3.5-V power supply.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The effect of TGFbeta1 on the expression and phosphorylation of key cell-cycle regulators in malignant B cells. (2004)

Our investigation of the effect of TGFbetal on cell-cycle progression of a non-Hodgkin's lymphoma cell line of follicular lymphoma subtype showed that the TGFbeta1-induced growth arrest of malignant B cells was associated with the activation of CIP/KIP family members of cdk inhibitors.
Distributed virtual reality (1995)

Article Free Access Share on Distributed virtual reality: an overview Author: Bernie Roehl University of Waterloo University of WaterlooSearch about this author Authors Info & Claims VRML '95: Proceedings of the first symposium on Virtual reality modeling languageJanuary 1995Pages 39–43https://doi.org/10.1145/217306.217312Published:01 January 1995Publication History 7citation718DownloadsMetricsTotal Citations7Total Downloads718Last 12 Months221Last 6 weeks20 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Synergistic roles of HslVU and other ATP-dependent proteases in controlling in vivo turnover of sigma32 and abnormal proteins in Escherichia coli (1997)

Production of abnormal proteins during steady-state growth induces the heat shock response by stabilizing normally unstable sigma32 (encoded by the rpoH gene) specifically required for transcription of heat shock genes. We report here that a multicopy plasmid carrying the hslVU operon encoding a novel ATP-dependent protease inhibits the heat shock response induced by production of human prourokinase (proUK) in Escherichia coli. The overproduction of HslVU (ClpQY) protease markedly reduced the stability and accumulation of proUK and thus reduced the induction of heat shock proteins. In agreement with this finding, deletion of the chromosomal hslVU genes significantly enhanced levels of proUK and sigma32 without appreciably affecting cell growth. When the deltahslVU deletion was combined with another protease mutation (lon, clpP, or ftsH/hflB), the resulting multiple mutations caused higher stabilization of proUK and sigma32, enhanced synthesis of heat shock proteins, and temperature-sensitive growth. Furthermore, overproduction of HslVU protease reduced sigma32 levels in strains that were otherwise expected to produce enhanced levels of sigma32 due either to the absence of Lon-ClpXP proteases or to the limiting levels of FtsH protease. Thus, a set of ATP-dependent proteases appear to play synergistic roles in the negative control of the heat shock response by modulating in vivo turnover of sigma32 as well as through degradation of abnormal proteins.
The Precipitation of Monodispersed α-Iron(III) Oxide Particles from Iron(III) Chloride–Glycine System in Aqueous and 2-Propanol/Water Media (1986)

Abstract Monodispersed α-iron(III) oxide (hematite) particles were prepared by aging iron(III) chloride solutions in the presence of glycine at elevated temperatures, 98–100 °C. An aqueous solution of glycinatoiron (III) complex directly gave monodispersed double spheres of hematite, ≈4 μm in size, under the specified conditions, for example, 2.0×10−2 mol dm−3 FeCl3, 0.60 mol dm−3 glycine, and 0.46 mol dm−3 HCl for 96 h. The hematite particles grew up through the polynuclear layers mechanism. By the forced hydrolysis in 2-propanol/water mixed solution of 30% by volume, monodispersed cuboidal hematite particles, 0.06–0.43 μm in size, were also obtained through the conversion of β-iron(III) hydroxide oxide previously deposited. The nucleation rate was markedly affected by acidity at the latter case. The formation processes of these monodispersed hematite particles are discussed.
<i>Abies</i> seed protein profile divergent from other <i>Pinaceae</i> (1991)

Summary Jensen, U. & Lixue, C.: Abies seed protein profile divergent from other Pinaceae. ‐ Taxon 40: 435–440. 1991. ‐ ISSN 0040‐0262. Legumin‐like 55 KD dimers were found to belong to a major seed storage protein in most genera of Pinaceae. However, the 12 Abies species investigated proved to be an exception, failing to reveal any such proteins in the seeds.
Energy, wealth, and human development: Why and how biomass pretreatment research must improve (2012)

A high level of human development is dependent on energy consumption (roughly 4 kW per person), and most developed countries that have reached this level have done so through the extensive use of fossil energy. However, given that fossil resources are finite, in order for developed countries to maintain their level of development and simultaneously allow developing countries to reach their potential, it is essential to develop viable renewable energy alternatives. Of particular importance are liquid fuel replacements for petroleum, the fossil resource that primarily drives commerce and economic growth. The intent of this article is to remind our fellow biofuel researchers, particularly those involved in lignocellulosic pretreatment, of these global issues and the serious nature of our work. We hope that this will inspire us to generate and report higher quality and more thorough data than has been done in the past. Only in this way can accurate comparisons and technoeconomic evaluations be made for the many different pretreatment technologies that are currently being researched. The data that primarily influence biorefinery economics can be subdivided into three main categories: yield, concentration, and rate. For these three categories we detail the specific data that should be reported for pretreatment research. In addition, there is other information that is needed to allow for a thorough comparison of pretreatment technologies. An overview of these criteria and our comparison of the current state of a number of pretreatment technologies with respect to these criteria are covered in the last section.
Role of the Catalyst in the Growth of Single-Wall Carbon Nanotubes (2006)

Classical molecular dynamics simulations are carried out to analyze the physical state of the catalyst, and the growth of single-wall carbon nanotubes under typical temperature and pressure conditions of their experimental synthesis, emphasizing the role of the catalyst/substrate interactions. It is found that a strong cluster/substrate interaction increases the cluster melting point, modifying the initial stages of carbon dissolution and precipitation on the cluster surface. Experiments performed on model Co-Mo catalysts clearly illustrate the existence of an initial period where the catalyst is formed and no nanotube growth is observed. To quantify the nature of the Co-Mo2C interaction, quantum density functional theory is applied to characterize structural and energetic features of small Co clusters deposited on a (001) Mo2C surface, revealing a strong attachment of Co-clusters to the Mo2C surface, which may increase the melting point of the cluster and prevent cluster sintering.
Ataxic variant of Alzheimer's disease caused by Pro117Ala PSEN1 mutation (2007)

Kernig's sign is the most common and, apart from nuchal rigidity, the only quantifiable sign of meningeal irritation. 3 Kernig's sign is some- times interpreted as positive when the knee cannot be extended beyond 135 .4 We considered
Fuzzy models—What are they, and why? [Editorial] (1993)

IT is my great pleasure to welcome you to the inaugural issue of the IEEE TRANSACTIONOSN FUZZY SYSTEMS. Many of you are probably quite familiar with the basic ideas underlying fuzzy sets and systems that utilize fuzzy models. However, there will also be readers who are looking at the contents of this issue, wondering what it's all about. For this latter group, the papers in this first issue may seem bewildering, for they are quite technical, and none are tutorial in nature. Consequently, this preface is divided into two parts. Section I contains a brief introduction to the basic ideas of our science, in hopes that this glimpse will help you understand the articles, but perhaps more importantly, pique your interest in fuzzy models. Section I1 gives a short prCcis and historical perspective of the field, and how it has led to the creation of this journal.
New stripe-geometry laser with simplified fabrication process (1979)

A new type of GaAs-GaAlAs stripe-geometry laser with an appreciably simplified fabrication process is described. Owing to the excellent lateral current confinement of this structure, low threshold current densities are achieved even for very narrow stripe widths. In addition, the built-in passive wave-guiding stabilises the fundamental horizontal transverse mode, thereby avoiding nonlinearities in the light output against current characteristic. For 3μm wide and 175 μm long lasers, threshold currents of 30–35 mA are achieved and stable transverse and longitudinal monomode emission has been observed up to more than 5 mW light power output.
Receiver synchronization in video streaming with short latency over asynchronous networks (2010)

Video transfers are an expected driver application area of the future Internet. When sending real-time video signals over an asynchronous network, such as Ethernet, some mechanisms need to be used to adjust the rendering speed on the receiver to the data source rate on the sender. The problem is more difficult when an ultra high-definition resolution is used (such as 4K × 2K). In this paper we discuss design options and our practical experience with implementation and field trial.
A Secure Protocol to Distribute Unlinkable Health Data (2018)

Health data that appears anonymous, such as DNA records, can be re-identified to named patients via location visit patterns, or trails. This is a realistic privacy concern which continues to exist because data holders do not collaborate prior to making disclosures. In this paper, we present STRANON, a novel computational protocol that enables data holders to work together to determine records that can be disclosed and satisfy a formal privacy protection model. STRANON incorporates a secure encrypted environment, so no data holder reveals information until the trails of disclosed records are provably unlinkable. We evaluate STRANON on real-world datasets with known susceptibilities and demonstrate data holders can release significant quantities of data with zero trail re-identifiability.
Peanut oral immunotherapy in adolescents: study protocol for a randomized controlled trial (2015)

ClinicalTrial.gov: NCT02046083 (23 January 2014).
The endonuclease domain of the LINE-1 ORF2 protein can tolerate multiple mutations (2016)

Overall, our data demonstrate that the full-length ORF2p or the ENp alone can tolerate several specific single and multiple point mutations in the endonuclease domain without significant impairment of their ability to support Alu mobilization or induce DNA damage, respectively.
Space robotics programs at Sandia National Laboratories (1993)

Existing robotic rover and space satellite technologies at Sandia National Laboratories (SNL), coupled with existing launch vehicles and converted military Multiple Independent Reentry Vehicle (MIRV) technologies, can be applied towards the realization of a robotic lunar rover mission in the near term. SNL`s Advanced Vehicle Development Department has been designing, producing, and operating prototype rover systems at the Robotic Vehicle Range facility since 1984, and has extensive experience with teleoperated and semiautonomous mobile robotic systems. SNL`s Space Systems Directorate has been designing, producing, and operating satellite systems and subsystems in earth orbit for national security missions since the early 1960`s. The facilities and robotic vehicle fleet at SNL`s Robotic Vehicle Range (SNL-RVR) have been used to support technology base development in applications ranging from DoD battlefield and security missions, to multi-agency nuclear emergency response team exercises and the development of a prototype robotic rover for planetary exploration. Recent activities at the SNL-RVR include the Robotic All Terrain Lunar Exploration Rover (RATLER) prototype development program, exploratory studies on a Near Term Lunar Return Mission scenario for small robotic rovers based on existing space hardware technology, and demonstrations of the utility of existing rover technologies for performing remote field geology tasks similar to those envisioned on a robotic lunar rover mission. Specific technologies demonstrated include low data rate teleoperation, multi-vehicle control, remote site and sample inspection, and standard bandwidth stereo vision. The paper describes Sandia National Laboratories` activities in the Space Robotics area, and highlights the laboratory`s supporting technical capabilities.
CXCL4-induced migration of activated T lymphocytes is mediated by the chemokine receptor CXCR3 (2008)

The chemokine CXCL4/platelet factor-4 is released by activated platelets in micromolar concentrations and is a chemoattractant for leukocytes via an unidentified receptor. Recently, a variant of the human chemokine receptor CXCR3 (CXCR3-B) was described, which transduced apoptotic but not chemotactic signals in microvascular endothelial cells following exposure to high concentrations of CXCL4. Here, we show that CXCL4 can induce intracellular calcium release and the migration of activated human T lymphocytes. CXCL4-induced chemotaxis of T lymphocytes was inhibited by a CXCR3 antagonist and pretreatment of cells with pertussis toxin (PTX), suggestive of CXCR3-mediated G-protein signaling via Galphai-sensitive subunits. Specific binding by T lymphocytes of the CXCR3 ligand CXCL10 was not effectively competed by CXCL4, suggesting that the two are allotopic ligands. We subsequently used expression systems to dissect the potential roles of each CXCR3 isoform in mediating CXCL4 function. Transient expression of the CXCR3-A and CXCR3-B isoforms in the murine pre-B cell L1.2 produced cells that migrated in response to CXCL4 in a manner sensitive to PTX and a CXCR3 antagonist. Binding of radiolabeled CXCL4 to L1.2 CXCR3 transfectants was of low affinity and appeared to be mediated chiefly by glycosaminoglycans (GAGs), as no specific CXCL4 binding was observed in GAG-deficient 745-Chinese hamster ovary cells stably expressing CXCR3. We suggest that following platelet activation, the CXCR3/CXCL4 axis may play a role in T lymphocyte recruitment and the subsequent amplification of inflammation observed in diseases such as atherosclerosis. In such a setting, antagonism of the CXCR3/CXCL4 axis may represent a useful, therapeutic intervention.
Direct white-light from core-shell-like sphere with Sr 3 Mg- (2013)

∗ This work has been supported by the National Natural Science Foundation of China (Nos.21076161, 50802062 and 50872091). ∗∗ E-mails: jcdeng@tjut.edu.cn; djwang@tjut.edu.cn Solid state lighting of white-light-emitting diode (WLED) technology has ever emerged into the next-generation lighting source. The currently commercialized WLEDs are fabricated by combining yellow-emitting phosphor of Y3Al5O12:Ce 3+ with blue-emitting phosphor of InGaN. For indoor lighting, this combination is not satisfactory to construct full spectrum white light owing to the deficits of green component and red component in color mixture. An approach by combining AlGaInP red chips with InGaN blue chips indeed results in the problems of unmatched forward bias driving current, which leads to a time-dependent shift of the color point. A more reasonable solution has been proposed by combining tricolor phosphors of blue, green and red with near ultraviolet (NUV) chips. It has been recognized that the NUV chips with 380 nm to 410 nm emission exhibit the highest internal quantum efficiencies. Many NUV excitable phosphors have emerged recently, such as SrZn2(PO4)2:Eu , Mn and Ca3Sc2Si3O12:Ce , Mn. The approach by using Mn for red component is comparable to all-nitride phosphor in effective cost. It is noted that the color mixture for white light with these phosphors is realized by blending the micrometer sized powder, which leads to re-absorption among particles. A novel method by using core-shell structured phosphor has been proposed to suppress the re-absorption. For the presently concerned Ba3MgSi2O8 and Sr2SiO4 silicate hosted phosphors, their high quantum efficiencies have drawn the attention of researchers. We also have been involved in a series of approaches with respect to a simultaneous band emission of red and blue light and a full spectrum white emission. The superior chemical stability of A3MgSi2O8 (A=Ba, Sr, Ca) to A2SiO4 (A=Ba, Sr, Ca) has been examined elsewhere, and the thermal stablity of Sr2SiO4:Eu 2+