gebhart/patrepeval huggingface dataset:
Exotic Order in Simple Models of Bosonic Systems (2002)

We show that simple Bose Hubbard models with unfrustrated hopping and short range two-body repulsive interactions can support stable fractionalized phases in two and higher dimensions, and in zero magnetic field. The simplicity of the constructed models advances the possibility of a controlled experimental realization and novel applications of such unconventional states.
Customised Rapid Manufactured Parts: Technology and Case Studies from the Custom-Fit Project (2009)

The design and manufacture of individually customised products is generally restricted to bespoke clothing or footwear for very wealthy customers. The aim of the Custom-Fit project was to develop a fast, flexible and economically viable route for the manufacture of individually customised parts. These products not only provide improved comfort levels but also provide better functional performance, including enhanced safety for the user. This 4.5 year, European Commission subsidised €16 million project, supported by the EU, involving 30 partners across the breadth of the Europe finished in early 2009. This paper will showcase the technology developed: CAD packages which automate the design process and three new rapid manufacturing methods. It will also include case studies on a range of customised products, including customised Motorcycles helmets. The case studies not only demonstrate the performance benefits of individual customisation but also show the potential for new approaches to product design. More information at www.Custom-Fit.org.
Application of software radio to the third generation mobile telecommunications (2003)

The third generation (3G) mobile telecommunication systems (IMT-2000) are under consideration. The systems will be put into commercial use in the year 2000 and later. At the beginning of their operation, the second-generation systems seem to be coexisting. Therefore, the transceiver equipment of the base station (BS) and mobile station (MS) should support the operation of these systems from the viewpoint of system compatibility. In this case, so-called multi-mode/multi-band operation is required for users' convenience. Furthermore, realization of small sized and low power consumption handy terminals is necessary. The software radio approach is one of the most promising techniques for this purpose. This paper describes the application of software radio technique to realize the multi-mode transceiver for 3G system.
Fast structure alignment for protein databank searching (1992)

A fast method is described for searching and analyzing the protein structure databank. It uses secondary structure followed by residue matching to compare protein structures and is developed from a previous structural alignment method based on dynamic programming. Linear representations of secondary structures are derived and their features compared to identify equivalent elements in two proteins. The secondary structure alignment then constrains the residue alignment, which compares only residues within aligned secondary structures and with similar buried areas and torsional angles. The initial secondary structure alignment improves accuracy and provides a means of filtering out unrelated proteins before the slower residue alignment stage. It is possible to search or sort the protein structure databank very quickly using just secondary structure comparisons. A search through 720 structures with a probe protein of 10 secondary structures required 1.7 CPU hours on a Sun 4/280. Alternatively, combined secondary structure and residue alignments, with a cutoff on the secondary structure score to remove pairs of unrelated proteins from further analysis, took 10.1 CPU hours. The method was applied in searches on different classes of proteins and to cluster a subset of the databank into structurally related groups. Relationships were consistent with known families of protein structure.
Security of Electronic Payment Systems: A Comprehensive Survey (2017)

This comprehensive survey deliberated over the security of electronic payment systems. In our research, we focused on either dominant systems or new attempts and innovations to improve the level of security of the electronic payment systems. This survey consists of the Card-present (CP) transactions and a review of its dominant system i.e. EMV including several researches at Cambridge university to designate variant types of attacks against this standard which demonstrates lack of a secure "offline" authentication method that is one of the main purpose of using the smart cards instead of magnetic stripe cards which are not able to participate in authentication process, the evaluation of the EMV migration from RSA cryptosystem to ECC based cryptosystem 3. The evaluation of the Card-not-present transactions approaches including 3D Secure, 3D SET, SET/EMV and EMV/CAP, the impact of concept of Tokenization and the role of Blind Signatures schemes in electronic cash and E-payment systems, use of quantum key distribution (QKD) in electronic payment systems to achieve unconditional security rather than only computational assurance of the security level by using traditional cryptography, the evaluation of Near Field Communication (NFC) and the contactless payment systems such as Google wallet, Android Pay and Apple Pay, the assessment of the electronic currency and peer to peer payment systems such as Bitcoin. The criterion of our survey for the measurement and the judgment about the quality of the security in electronic payment systems was this quote: "The security of a system is only as strong as its weakest link"
Defining and identifying communities in networks (2004)

The investigation of community structures in networks is an important issue in many domains and disciplines. This problem is relevant for social tasks (objective analysis of relationships on the web), biological inquiries (functional studies in metabolic and protein networks), or technological problems (optimization of large infrastructures). Several types of algorithms exist for revealing the community structure in networks, but a general and quantitative definition of community is not implemented in the algorithms, leading to an intrinsic difficulty in the interpretation of the results without any additional nontopological information. In this article we deal with this problem by showing how quantitative definitions of community are implemented in practice in the existing algorithms. In this way the algorithms for the identification of the community structure become fully self-contained. Furthermore, we propose a local algorithm to detect communities which outperforms the existing algorithms with respect to computational cost, keeping the same level of reliability. The algorithm is tested on artificial and real-world graphs. In particular, we show how the algorithm applies to a network of scientific collaborations, which, for its size, cannot be attacked with the usual methods. This type of local algorithm could open the way to applications to large-scale technological and biological systems.
Latency effects and periodic structures in light-induced frustrated etching of Fe:doped LiNbO3 (2000)

Single crystals of z-cut 0.05% Fe:doped lithium niobate (Fe:LiNbO3), have been etched in a mixture of HF and HNO3 acids, under simultaneous illumination from a ∼100 mW 488 nm wavelength Ar ion laser light source, focused to power densities of ∼50 W cm−2 at the crystal surface exposed to the etchant. Etching is partially inhibited in illuminated regions, and the degree of inhibition shows a systematic latency: sites illuminated early in the etch run resist further etching even after the light is removed. Etched structures additionally exhibit regular periodic features of ∼0.5 μm scale length. Details of these structures are shown, and the latent etching effect is discussed.
Expression of the MAGE-A4 and NY-ESO-1 cancer-testis antigens and T cell infiltration in non-small cell lung carcinoma and their prognostic significance (2006)

Cancer-testis (CT) antigens were identified as a group of highly attractive targets for cancer immunotherapy because of their expression in a variety of malignant tumors but solely in the testis among the normal adult tissues. To evaluate the potential of two members of this family, MAGE-A4 and NY-ESO-1 antigens, for cancer vaccine in non-small cell lung carcinoma (NSCLC), we examined the expression of these antigens and T cell infiltration in tumor tissue, and evaluated their prognostic significance. One hundred fifty-seven patients with NSCLC were studied. Reverse transcription-PCR was performed to evaluate MAGE-A4 and NY-ESO-1 expression. Immunohistochemistry was performed for NY-ESO-1 expression and T cell infiltration into the tumor site. Survival analysis was also performed. MAGE-A4 and NY-ESO-1 were expressed in 40 of 141 (28.4%) and 13 of 157 (8.3%) NSCLC respectively. Both CT antigens were more frequently expressed in squamous cell carcinoma (SCC) than in adenocarcinoma. An inverse correlation was found between MAGE-A4 expression and patient survival in advanced stage cancers. Combined infiltration of both CD4+ and CD8+ T cells into tumor nest predicted better survival. There was no correlation, however, between lymphocyte infiltration and antigen expression in the tumor. MAGE-A4 expression in advanced group and T cell infiltration may provide prognostic information. Lastly, these CT antigens, especially MAGE-A4, may represent potential targets for cancer immunotherapy in patients with NSCLC.
Natural fats and oils route to fatty alcohols (1983)

The Philippines will be the site for a chemical plant that will use coconut oil to make fatty alcohols by means of a direct hydrogenation route - eliminating an intermediate esterification step. The facility will produce about 65,000 tonnes/yr of coconut fatty acid and 7,900 tonnes/yr of glycerine. About half of the fatty acid produced will be used to make 29,000 tonnes/yr of fatty alcohols. The principles and operation of the process are outlined.
Poly(ADP-ribose) polymerase from Ehrlich ascites-tumour cells. Amino acid composition, <i>N</i>-terminal analysis and chemical cleavage of the purified protein (1980)

Poly(ADP-ribose) polymerase was purified from Ehrlich ascites-tumour cells by two novel methods. Analysis for amino acid composition revealed a high percentage of acidic amino acids or their amides, and of basic amino acids. N-Terminal analysis with dansyl chloride revealed no terminal amino acid, indicating a blocked N-terminal amino group. Analysis by gel electrophoresis of protein treated with 3-bromo-3-methyl-2-[(2-nitrophenylthio)-3H-indole, under conditions where selective cleavage of the polypeptide chain at tryptophan residues is obtained, showed six major peptide bands.
Optimization of injection mould gate location for cash register face cover (2007)

Moldflow Plastics Insight(MPI) was applied to optimize the design of gate location of an injection mould for the face cover of a cash register.The effect of the gate location on the quality of the plastic part was analyzed based on CAE simulation.Then the gate location was optimized by synthetically applying experiential qualitative analysis and CAE-based quantitative simulation.
Stimulation of the Megasphaera elsdenii’s butyrate production in continuous culture by a yeast additive (2001)

Continuous culture study of the ruminal bacterium Megasphaera elsdenii using lactate as carbon source is reported. Butyrate, the minor product in batch culture, was the main product in continuous culture. Under steady state conditions the biomass concentration was increased from 0.46 to 0.72 g l-1. Addition of Yea Sacc did not result an increased availability of carbon. The produced amounts of valerate and CO2 were calculated by using a combined carbon and degree of reduction balances. According to these results, the lactate catabolism of M. elsdenii was changed by the presence of yeast additive, yielding more butyrate and diminishing the production of valerate, while acetate and propionate production was not affected. Results reported in this work suggested that soluble compounds present in the yeast additive filtrate enhanced the anabolism of M. elsdenii and modified the carbon fluxes through its pathways by increasing butyrate and decreasing valerate production in continuous culture.
Neurotrophins and the specification of neuronal phenotype (1996)

Nerve growth factor, brain derived neurotrophic factor and neurotrophin-3 all influence sensory neurons derived from the dorsal root ganglia. Traditionally these neurotrophins have been thought of as survival factors for sensory neurons during their development. Recent evidence from experiments where the in vivo levels of these proteins has been manipulated indicates that they may influence the development of specific sensory neuron phenotypes. In this review these experiments are discussed in relation to the mechanisms by which neurotrophins could influence the phenotypic fate of sensory neurons. The first mechanism requires that when a neuron becomes dependent for survival on a neurotrophin the availability of the factor simply influences the number of neurons surviving with a certain modality. This model requires that neurotrophin responsiveness is a determinant of the possible modalities that the neuron may acquire. The second mechanism requires that the availability of a given neurotrophin influences how many neurons can differentiate into different sensory neuron phenotype independent of survival. The available experimental data is discussed in relation to these two models.
Cell Damage and Death by Autoschizis in Human Bladder (RT4) Carcinoma Cells Resulting from Treatment with Ascorbate and Menadione (2010)

A human bladder carcinoma cell line RT4 was sham-treated with buffer or treated with ascorbate (VC) alone, menadione alone (VK(3)), or a combination of ascorbate:menadione (VC+VK(3)) for 1, 2, and 4 h. Cytotoxic damage was found to be treatment-dependent in this sequence: VC+VK(3)>VC>VK(3)>sham. The combined treatment induced the greatest oxidative stress, with early tumor cell injury affecting the cytoskeletal architecture and contributing to the self-excisions of pieces of cytoplasm freed from organelles. Additional damage, including a reduction in cell size, organelle alterations, nuclear damage, and nucleic acid degradation as well as compromised lysosome integrity, is caused by reactivation of DNases and the redox cycling of VC or VC+VK(3). In addition, cell death caused by VC+VK(3) treatment as well as by prolonged VC treatment is consistent with cell demise by autoschizis, not apoptosis. This report confirms and complements previous observations about this new mode of tumor cell death. It supports the contention that a combination of VC+VK(3), also named Apatone, could be co-administered as a nontoxic adjuvant with radiation and/or chemotherapies to kill bladder tumor cells and other cancer cells without any supplementary risk or side effects for patients.
SEWAGE EFFLUENT MANAGEMENT - WASTE OR ASSET? (2011)

The removal of essential nutrients from sewage presents several engineering problems, not the least is an understanding of the ultimate benefit or harm these nutrients may have to the environment. Nutrient removal by chemical precipitation and biological processes is easily solved by structural additions to a sewage treatment plant. However, just outside the built environment is the one environment that is capable of assimilating those nutrients with a reward to the operators by way of organic produce. This paper examines typical sewage quality from rural towns as well as metropolitan areas and converts the data to surrogate fertiliser values.
Regulation of Angiogenesis and Bone Regeneration with Natural and Synthetic Small Molecules (2013)

Regeneration of bone requires the coordinated processes of angiogenesis and osteogenesis. These repair mechanisms are closely linked through both direct cell-cell contact and indirect paracrine signaling among osteoblasts, endothelial cells, and other cell types. The vasculature provides a source of nutrients, oxygen, metabolic substrates, and access for circulating cells that help to support new bone formation. The complexity of the endogenous signaling axis that promotes angiogenesis provides numerous opportunities for therapeutic intervention ranging from progenitor cell mobilization to endothelial proliferation and sprouting. Small molecules are particularly appealing for regenerative medicine applications because many exhibit extended in vivo stability, low cost, and scalable production. Innovative techniques for developing small molecules such as high throughput functional assays and broad-spectrum database analysis techniques have led to the development of new compounds and the identification of novel applications of existing drugs. In addition, rapid advances in biomaterials design and synthesis provide platforms to deliver therapeutic small molecules to sites of bone injury. This review presents an overview of current strategies for harnessing endogenous healing mechanisms using small molecules by targeting angiogenesis, osteogenesis, or both.
High affinity promotes more effective ADCC by anti-HER2/<i>neu</i> monoclonal antibodies (2006)

2538 Background: Although monoclonal antibodies have emerged as useful cancer therapeutics, the antibody structural features and biologic properties that maximize therapeutic benefit are not fully understood. Antibody-dependent cellular cytotoxicity (ADCC) is believed to be a major mechanism of some anti-cancer antibodies. Herein, we describe the relationship between antibody affinity and the biologic properties of ADCC. Methods: A series of human IgG1 antibodies was created from the anti-HER2/neu C6.5 scFv and its affinity mutants (affinity ranging from 10 −7 to 10 −11 M). The IgGs were tested for their ability to elicit ADCC using a standard 51 Cr-release assay. The ability of these IgGs to inhibit tumor cell proliferation and to induce apoptosis was evaluated using a colorimetric cell proliferation assay and homogeneous caspase assay/Annexin-V-FLUOS assay, respectively. Three tumor cell lines with differing levels of HER2/neu expression were used as target cells, and unactivated human PBMC from healthy donors were the effector cells. Results: There was a clear influence of both intrinsic and functional affinity on ADCC, with higher levels of peak cytotoxicity as apparent affinity approached 10 −11 M. Among the antibodies with apparent affinity of 10 −11 M, antibodies with higher intrinsic affinities elicited more ADCC. There also was an affinity-dependent increase in cytotoxicity at lower antibody concentrations and lower effector: target ratios. These antibodies elicited more cytotoxicity against tumor cells expressing high levels of HER2/neu than against cells expressing lower amounts of HER2/neu. None of these IgGs inhibited tumor cell proliferation, or induced apoptosis. Conclusions: Additional studies are needed to determine why, at the same functional avidity, ADCC is improved in antibodies with higher intrinsic affinities. These findings justify the examination of high affinity antibodies for ADCC promotion, although the impaired tumor targeting associated with high affinity may be an important confounding factor in the design of unconjugated anti-tumor antibodies. A careful examination of antibody structure: function relationships is required to develop optimized therapeutic unconjugated antibodies. No significant financial relationships to disclose.
Targeted Inhibition of Osteopontin Expression in the Mammary Gland Causes Abnormal Morphogenesis and Lactation Deficiency (2000)

Osteopontin (OPN) is a sialic acid-rich, adhesive, extracellular matrix (ECM) protein with Arg-Gly-Asp cell-binding sequence that interacts with several integrins, including alpha(v)beta(3). Since the ECM is a key regulator of mammary gland morphogenesis, and mammary epithelial cells express OPN at elevated levels, we sought to determine whether this protein plays a role in the postnatal mammary gland development. By generating transgenic mice that express OPN antisense-RNA (AS-OPN mice) in the mammary epithelia we achieved suppression of OPN production in this organ. The pregnant AS-OPN mice displayed a lack of mammary alveolar structures, a drastic reduction in the synthesis of beta-casein, whey acidic milk protein, and lactation deficiency. In agreement with these findings, we uncovered that a mammary cell line, NMuMG, which undergoes both structural and functional differentiation on ECM-coated plates, when transfected with an antisense OPN-cDNA construct, failed to undergo such differentiation. Furthermore, the results of gel-invasion assays demonstrated that these cells manifest elevated matrix metalloproteinase (MMP) activity when OPN expression is significantly reduced. The identity of this proteinase as MMP-2 is confirmed by Western blotting, zymography, and inhibition of its activity by a specific inhibitor, TIMP-2. Taken together, our results demonstrate, for the first time, an essential role of OPN in mammary gland differentiation and that the molecular mechanism(s) of its action, at least in part, involves down-regulation of MMP-2.
Improvement of Bacillus sphaericus toxicity against dipteran larvae by integration, via homologous recombination, of the Cry11A toxin gene from Bacillus thuringiensis subsp. israelensis (1997)

Integrative plasmids were constructed to enable integration of foreign DNA into the chromosome of Bacillus sphaericus 2297 by in vivo recombination. Integration of the aphA3 kanamycin resistance gene by a two-step procedure demonstrated that this strategy was applicable with antibiotic resistance selection. Hybridization experiments evidenced two copies of the operon encoding the binary toxin from B. sphaericus in the recipient strain. The Bacillus thuringiensis subsp. israelensis cry11Aal gene (referred to as cry11A), encoding a delta-endotoxin with toxicity against Culex, Aedes, and Anopheles larvae, was integrated either by a single crossover event [strain 2297 (::pHT5601), harboring the entire recombinant plasmid] or by two successive crossover events [strain 2297 (::cry11A)]. The level of the Cry11A production in B. sphaericus was high; two crystalline inclusions were produced in strain 2297 (::pHT5601). Synthesis of the Cry11A toxin conferred toxicity to the recombinant strains against Aedes aegypti larvae, for which the parental strain was not toxic. Interestingly, the level of larvicidal activity of strain 2297 (::pHT5601) against Anopheles stephensi was as high as that of B. thuringiensis subsp. israelensis and suggested synergy between the B. thuringiensis and B. sphaericus toxins. The toxicities of parental and recombinant B. sphaericus strains against Culex quinquefasciatus were similar, but the recombinant strains killed the larvae more rapidly. The production of the Cry11A toxin in B. sphaericus also partially restored toxicity for C. quinquefasciatus larvae from a population resistant to B. sphaericus 1593. In vivo recombination therefore appears to be a promising approach to the creation of new B. sphaericus strains for vector control.