gebhart/patrepeval huggingface dataset:
The corepressor N-CoR and its variants RIP13a and RIP13 1 directly interact with the basal transcription factors TFIIB, TAFII32 and TAFII70 (1998)

Repression of transcription by the classical nuclear receptors (e.g. TR, RAR), the orphan nuclear receptors (e.g. Rev-erbAalpha/beta), Mxi-1 and Mad bHLH-zip proteins and the oncoproteins PLZF and LAZ3/BCL6 is mediated by the corepressors N-CoR and SMRT. The interaction of the corepressors with the components involved in chromatin remodelling, such as the recruiting proteins Sin3A/B and the histone deacteylases HDAc-1 and RPD3, has been analysed in detail. The N-CoR/Sin3/HDAc complexes have a key role in the regulation of cellular proliferation and differentiation. However, the interaction of these corepressors with the basal transcriptional machinery has remained obscure. In this study we demonstrated that the N-terminalrepression domains and the receptor interactiondomains (RID) of N-CoR and its splice variants, RIP13a and RIP13Delta1, directly interact with TAFII32 in vivo and in vitro . We show that interaction domain II within the N-CoR and RIP13a RID is required for the interaction with TAFII32. We also observed that N-CoR directly interacts with each of the basal factors, TFIIB and TAFII70, and can simultaneously interact with all three basal factors in a non-competitive manner. Furthermore, we provide evidence that suggests the RVR/Rev-erbbeta-corepressor complex also interacts with the general transcriptional machinery, and that the physicalassociation of TFIIB with N-CoR also occurs in the presence of Sin3B and HDAc-1. Interestingly, we observed that N-CoR expression ablated the functional interaction between TFIIB and TAFII32 that is critical to the initiation of transcription. In conclusion, this study demonstrates that the N-terminal repressor region and the C-terminal RIDs are part of the corepressor contact interface that mediates the interaction with the general transcription factors, and demonstrates that TAFs can also directly interact with corepressors to mediate signals from repressors to the basal machinery. We also suggest that N-CoR interacts with the central components of the transcriptional initiation process (TFIIB, TAFs) and locks them into a non-functional complex or conformation that is not conducive to transcription.
Fast approximate visible set determination for point sample clouds (2003)

We present a fast, efficient method to determine approximate visible sets for vegetation rendered as point sample clouds. A hardware accelerated preprocessing step is used to determine exact visibility for a selected set of views; at runtime the current view is rendered using an approximate visible set constructed from the three closest precalculated views. We will further demonstrate how this method leads to a significant per-frame reduction of the original data size.
Nidek MK 2000 Microkeratome Clinical Evaluation (2002)

The Nidek MK 2000 microkeratome was simple, safe, predictable, and reliable for LASIK.
Effect of the αGal Epitope on the Response to Small Intestinal Submucosa Extracellular Matrix in a Nonhuman Primate Model (2009)

The Galalpha1,3Galbeta1,4GlcNAc-R (Gal) epitope is a major factor in the hyperacute rejection of pig organ transplants in primates. Biologic scaffold materials used for tissue reconstruction and composed of xenogeneic extracellular matrix (ECM) may contain the Gal epitope. However, the effect of this epitope upon the host response is controversial. The present study investigated the effect of the Gal epitope upon the host response to a porcine-derived ECM in an African Green monkey (Cholrocaebus aethiops) abdominal wall resection model. Histologic methods, serology, complement-dependent cytotoxicity, and gene expression profiling were used to evaluate the host response to allogeneic and both wild-type and Gal-deficient xenogeneic scaffold materials. Although expression of the Gal epitope induced an increase in serum anti-Gal antibodies in recipients, no other differences were noted in the host response between test articles. All ECM scaffolds were well tolerated and showed constructive remodeling during the study period. Recipients of all test articles showed no histologic or humoral evidence of sensitization when a second scaffold was implanted 45 days after the original surgery. The findings of the present study show that the presence of the Gal epitope within a porcine-derived ECM scaffold material elicits a serum antibody response, but no adverse effect upon tissue remodeling.
Aliovalent Doping in Colloidal Quantum Dots and Its Manifestation on Their Optical Properties: Surface Attachment versus Structural Incorporation (2016)

Doping colloidal quantum dots (CQDs) with aliovalent cations is a promising, yet underexplored, approach to control the optoelectronic properties in CQDs. In CQD doping, kinetics determine whether a dopant element will incorporate into the host crystal structure, while thermodynamics dictate the mechanism of dopant incorporation. Here, we show that those mechanisms can be readily monitored by simple optical measurements and XRD studies in CQD ensembles. Based on this, we outline the critical role of dopant solubility limit in CQD doping, bridging the gap between nanocrystalline and bulk semiconductors. Finally, we present a combined simulation and X-ray absorption fine structure (XAFS) data study to shed new insights on the origin of charge compensation upon doping in CQD materials that has, thus far, limited high doping efficacy, even under efficient dopant incorporation schemes.
One-pot multicomponent synthesis and antimicrobial evaluation ofsome novel pyrano-[2,3-c]- pyrazoles derivatives (2011)

In the present communication a simple and efficient synthesis of some new Pyrano-[2,3-c]- Pyrazoles derivatives are described by the one-pot condensation of a mixture of 3-methyl-1- phenyl-1H-pyrazol-5(4H)-one, substituted heterylaldehydes and malononitriles in Polyethylene glycol (PEG-400) as green reaction solvent, The chemical structure of the compounds was confirmed by IR,1H NMR and Mass spectral data. All the compounds of the series screened for their antimicrobial activity studies. The result revealed that most of the compounds showed good to moderate antimicrobial activity.
Espresso coffee : the chemistry of quality (1995)

Definition of quality definition of espresso the plant the raw bean roasting grinding packaging percolation the cup quality assurance.
The Scavenger Receptor SSc5D Physically Interacts with Bacteria through the SRCR-Containing N-Terminal Domain (2016)

The scavenger receptor cysteine-rich (SRCR) family comprises a group of membrane-attached or secreted proteins that contain one or more modules/domains structurally similar to the membrane distal domain of type I macrophage scavenger receptor. Although no all-inclusive biological function has been ascribed to the SRCR family, some of these receptors have been shown to recognize pathogen-associated molecular patterns (PAMP) of bacteria, fungi, or other microbes. SSc5D is a recently described soluble SRCR receptor produced by monocytes/macrophages and T lymphocytes, consisting of an N-terminal portion, which contains five SRCR modules, and a large C-terminal mucin-like domain. Toward establishing a global common role for SRCR domains, we interrogated whether the set of five SRCR domains of SSc5D displayed pattern recognition receptor (PRR) properties. For that purpose, we have expressed in a mammalian expression system the N-terminal SRCR-containing moiety of SSc5D (N-SSc5D), thus excluding the mucin-like domain likely by nature to bind microorganisms, and tested the capacity of the SRCR functional groups to physically interact with bacteria. Using conventional protein-bacteria binding assays, we showed that N-SSc5D had a superior capacity to bind to <i>Escherichia coli</i> strains RS218 and IHE3034 compared with that of the extracellular domains of the SRCR proteins CD5 and CD6 (sCD5 and sCD6, respectively), and similar <i>E. coli</i>-binding properties as Spα, a proven PRR of the SRCR family. We have further designed a more sensitive, real-time, and label-free surface plasmon resonance (SPR)-based assay and examined the capacity of N-SSc5D, Spα, sCD5, and sCD6 to bind to different bacteria. We demonstrated that N-SSc5D compares with Spα in the capacity to bind to <i>E. coli</i> and <i>Listeria monocytogenes</i>, and further that it can distinguish between pathogenic <i>E. coli</i> RS218 and IHE3034 strains and the non-pathogenic laboratory <i>E. coli</i> strain BL21(DE3). Our work thus advocates the utility of SPR-based assays as sensitive tools for the rapid screening of interactions between immune-related receptors and PAMP-bearing microbes. The analysis of our results suggests that SRCR domains of different members of the family have a differential capacity to interact with bacteria, and further that the same receptor can discriminate between different bacteria strains and species.
Developmental pharmacology and toxicology of anti‐HIV therapeutic agents: dideoxynucleosides <sup>1</sup> (1995)

As the incidence of human immunodeficiency virus (HIV) infection has increased in women over the past decade, the need for safe, effective therapy during pregnancy has increased concomitantly. Although dideoxynucleosides such as 3'-deoxy-3'-azidothymidine (AZT), 2',3'-dideoxyinosine (ddI), 2',3'-dideoxycytidine (ddC), and 2',3'-didehydro-3'-deoxythymidine have been approved for use in the general population, the administration, efficacy, and toxicity of these compounds during pregnancy and development are now being investigated. Initial human studies suggest that maternal use of AZT during pregnancy is well tolerated by both mother and child and provides a promising degree of protection from vertical HIV transmission to the infant. In vitro and animal models have greatly increased our understanding of the distribution and toxicity resulting from fetal dideoxynucleoside exposure. AZT, ddI, and ddC rapidly cross the placenta by simple diffusion but with different rates of transfer. In vivo data confirm the differential transfer of these compounds with AZT fetal exposure approximately twice that of ddI or ddC. Active phosphorylated metabolites have been detected in placental tissue after in vitro perfusion with AZT. The active triphosphate has not been detected in placental perfusion studies or in the fetal rhesus monkey 3 h after maternal exposure to ddI or ddC. Although in vitro and in vivo laboratory animal studies suggest the potential for toxicity with preimplantation exposure, the risk for teratogenic events after postimplantational exposure appears to be low at therapeutically effective concentrations of these dideoxynucleosides.
Tool handling and scheduling in a two-machine flexible manufacturing cell (1996)

In this paper we examine the issue of tool management in a flexible manufacturing cell. The type of system considered here is typical of mechanical manufacturing, in which large metallic parts are loaded on the machines and are not moved until processing completion. The architecture of the cell is characterized by the absence of on-board tool magazines on the machines. Although this permits the continuous maintenance and inspection of the tools and typically results in cost and workspace savings, it calls for more complex tool handling procedures. We present a heuristic to address the overall problem of assigning parts to machines, sequencing parts on each machine, and synchronizing tool movements. The results indicate that our method provides near-optimal solutions in terms of makespan and mean flow time. Further, we observe that the solution procedure is at least one order of magnitude faster than the approach currently used and also results in a much better mean flow time.
Two simple metal vapor deposition sources for downward evaporation in ultrahigh vacuum (1989)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation D. A. Steigerwald, W. F. Egelhoff; Two simple metal vapor deposition sources for downward evaporation in ultrahigh vacuum. Journal of Vacuum Science & Technology A 1 September 1989; 7 (5): 3123–3124. https://doi.org/10.1116/1.576325 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAVS: Science & Technology of Materials Interfaces and ProcessingJournal of Vacuum Science & Technology A Search Advanced Search |Citation Search
High temperature stress and spikelet fertility in rice (Oryza sativa L.) (2007)

In future climates, greater heat tolerance at anthesis will be required in rice. The effect of high temperature at anthesis on spikelet fertility was studied on IR64 (lowland indica) and Azucena (upland japonica) at 29.6 degrees C (control), 33.7 degrees C, and 36.2 degrees C tissue temperatures. The objectives of the study were to: (i) determine the effect of temperature on flowering pattern; (ii) examine the effect of time of day of spikelet anthesis relative to a high temperature episode on spikelet fertility; and (iii) study the interactions between duration of exposure and temperature on spikelet fertility. Plants were grown at 30/24 degrees C day/night temperature in a greenhouse and transferred to growth cabinets for the temperature treatments. Individual spikelets were marked with paint to relate fertility to the time of exposure to different temperatures and durations. In both genotypes the pattern of flowering was similar, and peak anthesis occurred between 10.30 h and 11.30 h at 29.2 degrees C, and about 45 min earlier at 36.2 degrees C. In IR64, high temperature increased the number of spikelets reaching anthesis, whereas in Azucena numbers were reduced. In both genotypes<or=1 h exposure to>or=33.7 degrees C at anthesis caused sterility. In IR64, there was no interaction between temperature and duration of exposure, and spikelet fertility was reduced by about 7% per degrees C>29.6 degrees C. In Azucena there was a significant interaction and spikelet fertility was reduced by 2.4% degrees Cd-1 above a threshold of 33 degrees C. Marking individual spikelets is an effective method to phenotype genotypes and lines for heat tolerance that removes any apparent tolerance due to temporal escape.
Figure-of-eight Shaped Metal-free Amide-containing Schiff-base Macrocycles and Two Dicobalt(III) Amide Complexes (2001)

Abstract Two 36-membered (2+2) Schiff-base macrocycles have been prepared and characterised without the use of template ions or high dilution techniques. Rather, intramolecular hydrogen-bonding and π-π interactions promote the isolation of these “figure-of-eight” products in good yields. Two cobalt(III) complexes of the 18-membered (1+1) Schiff-base macrocycles are formed when cobalt(II) is used as a template. The structures of one “figure-of-eight' metal-free (2+2) macrocycle and of one dicobalt(III) complex of a (1+1) macrocycle, in which the cobalt centres are octahedral, are presented. [H4L1tBu]2: C70H70N8O9, space group P-1, a=7.747(1), b=17.106(3), c=23.662(4) å, α=104.83(3), β=95.86(3), γ=97.80(3)°, U=2972.4(8) å3, Z=2, Dc=1.30 g cm−3, T=100K, 554 parameters, R1=0.072 [for 4137 reflections having F>4[(F)], wR2=0.191 and goodness of fit 0.97 (for all 8343 independent F2 data). [Co2(L1tBu)(OAc)2(pyridine)] 1.5DMF 0.5MeCN, C47.5H49N7O9.5Co2, space group P2(1)/n, a=13.067(2), b=26.071(4), c=14.023(3) å, β=93.02(1)°, U=4770.6(15) å3, Z=4, Dc=1.38 g cm−3, T=168 K, 622 parameters, R1=0.075 [for 5233 reflections having F > 4[⟨F⟩], wR2=0.133 and good ness of fit 1.08 (for all 8512 independent F2 data).
Benefits of Fast Battery Formation in a Model System (2021)

Lithium-ion battery formation affects battery cost, energy density, and lifetime. An improved understanding of the first cycle of solid-electrolyte interphase (SEI) growth on carbonaceous negative electrodes could aid in the design of optimized formation protocols. In this work, we systematically study SEI growth during the formation of carbon black negative electrodes in a standard carbonate electrolyte. We show that the initial ethylene carbonate (EC) reduction reaction occurs at ∼0.5–1.2 V during the first lithiation, except under fast lithiation rates (≥10C). The products of this EC reduction reaction do not passivate the electrode; only the SEI formed at lower potentials affects the second-cycle Coulombic efficiency. Thus, cycling quickly through the voltage regime of this reaction can decrease both formation time and first-cycle capacity loss, without an increase in subsequent-cycle capacity loss. We also show that the capacity consumed by this reaction is minimized at low temperatures and low salt concentrations. Finally, we discuss the mechanism behind our experimental results. This work reveals the fundamental processes underlying initial SEI growth on carbonaceous negative electrodes and provides insights for both optimizing the battery formation process and enabling novel electrolytes.
Field effect measurements in doped conjugated polymer films: Assessment of charge carrier mobilities (1995)

Conductivity and field-effect mobility measurements using metal-insulator-semiconductor field-effect-transistor devices and acceptor density measurements using metal-insulator- semiconductor (MIS) diodes are presented. The measurements were made on thin polymer films of the organic semiconductor, poly(β′-dodecyloxy-α,α′,-α′,α″terthienyl), which were doped to different conductivities using 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) as an oxidizing agent. It is found that both the field-effect mobility and the conductivity of these films increases superlinearly upon doping while the transistor amplification, the on/off ratio, decreases. Acceptor densities as obtained from MIS diode measurements are in close agreement with the bulk charge density as calculated from the DDQ content. However, the product of this bulk charge density, field-effect mobility, and the elementary charge e is a factor of 100 larger than the polymer conductivity. This indicates that the average mobility for charge carriers in the bulk is considerably lower than the field-effect mobility. It is considered that the bulk charge carriers are trapped by the Coulomb interaction with their parent charge compensating counter-ions, whereas charges in accumulation have no associated counter-ions and, therefore, are more mobile.
High-temperature carrier transport and thermoelectric properties of heavily La- or Nb-doped SrTiO3 single crystals (2005)

Electron and thermal transport properties, i.e., electrical conductivity, carrier concentration, Hall mobility, Seebeck coefficient, thermal conductivity, of heavily La- or Nb-doped SrTiO3 (STO) bulk single crystals were measured at high temperatures, (300–1050K) to clarify the influence of doping upon the thermoelectric performance of STO. The temperature dependence of Hall mobility and Seebeck coefficient changed at ∼750K in all samples because the dominant mechanism for carrier scattering changed with increasing temperature from coupled scattering by polar optical phonons and acoustic phonons to mere acoustic phonon scattering. The density-of-states effective mass of Nb-doped STO, which was estimated from the carrier concentration and Seebeck coefficient, was larger than that of La-doped STO. Thermal conductivity of the samples, which was similar to that of undoped STO single crystal, decreased proportionally to T−1, indicating that the phonon conduction takes place predominantly and the electronic contribution to thermal conductivity is negligible.
Prolotherapy Injections for Chronic Low Back Pain (2004)

There is conflicting evidence regarding the efficacy of prolotherapy injections in reducing pain and disability in patients with chronic low back pain. Conclusions are confounded by clinical heterogeneity among studies and by the presence of co-interventions. There was no evidence that prolotherapy injections alone were more effective than control injections alone. However, in the presence of co-interventions, prolotherapy injections were more effective than control injections, more so when both injections and co-interventions were controlled concurrently.
Mobility and Ionic Association of Lithium Salts in a Propylene Carbonate‐Ethyl Methyl Carbonate Mixed Solvent (1995)

Electrolytic conductivities of lithium salts have been measured in equimolar mixtures of propylene carbonate and either ethyl methyl carbonate or 1,2‐dimethoxyethane at 25°C over a salt concentration range of 10−2 to 10−3 mol dm−3. The limiting molar conductivities and association constants were calculated from the expanded Fuoss‐Hsia equation. The Walden product of lithium ion was not enhanced by the addition of ethyl methyl carbonate as observed in the case of 1,2‐dimethoxyethane, due to the lack of specific solvation. and in the propylene carbonate‐ethyl methyl carbonate mixed solvent formed solvent‐separated ion pairs, which resulted in decreased ion association.
A novel humanized mouse lacking murine P450 oxidoreductase for studying human drug metabolism (2017)

An incorrect version of the Supplementary Information was inadvertently published with this Article where the wrong file was included. The HTML has been updated to include the correct version of the Supplementary Information.
A digital hardware pulse-mode neuron with piecewise linear activation function (2003)

This paper proposes a new type of digital pulse-mode neuron that employs piecewise-linear function as its activation function. The neuron is implemented on field programmable gate array (FPGA) and tested by experiments. As well as theoretical analysis, the experimental results show that the piecewise-linear function of the proposed neuron is programmable and robust against the change in the number of input signals. To demonstrate the effect of piecewise-linear activation function, pulse-mode multilayer neural network with on-chip learning is implemented on FPGA with the proposed neuron, and its learning performance is verified by experiments. By approximating the sigmoid function by the piecewise-linear function, the convergence rate of the learning and generalization capability are improved.
Cirrhosis of the liver: new concepts. (1989)

Cirrhosis is a histologic term that requires liver biopsy for definitive diagnosis. Although we may usefully classify cirrhosis by cause, such as alcoholic cirrhosis, the morphologic diagnosis is confined to only a few descriptive terms. Cirrhosis is the end result of hepatocellular necrosis that initiates the inflammatory process. Hepatocellular necrosis induced by the hepatoviruses is caused by the host response to the parasitized cells rather than by the viruses themselves. Inflammatory cells, apparently by diverse mechanisms that include the immune system, stimulate the deposition of collagen around hepatocytes and in sinusoidal membranes, causing profound alteration in hepatocyte function and hepatic blood flow. Fully developed cirrhosis cannot be reversed with therapy presently available. Efforts to change morbidity and mortality of this common disease include preventive measures, attempts to manipulate the immune response, efforts to influence the biologic process of fibrosis, and, finally, attempts to induce resorption of established collagen. No acceptable therapy to prevent cirrhosis currently exists, but there is reason to believe that one can and will be developed in the future, probably through the discovery of better methods of eliminating the persistent infection by hepatoviruses. The most encouraging results to date come from experiments using prednisone followed by interferon, and from very preliminary results with methotrexate in specific circumstances. In the meantime, the clinician will continue to support the existing physiology, minimize and treat the complications, and offer support to the patient and family.