gebhart/patrepeval huggingface dataset:
Long-Term Results of Stereotaxy in the Treatment of Essential Tremor (1990)

In patients with severe tremor that is resistant to drug therapy, stereotactic coagulation can achieve a satisfactory and lasting reduction of the movement disorders. Very few long-term studies have been conducted following stereotactic operations. From 1964 to 1984, 104 patients with a diagnosis of essential tremor were operated on in the Division of Stereotaxy and Neuronuclear Medicine. After an average follow-up period of 8.6 years, 65 patients were examined. In 80%, the success of the stereotactic operation was still evident. Complete disappearance or substantial reduction of the tremor was determined in 69% and moderate improvement in 11.9% of the patients.
Characterization of cell lines derived from breast cancers and normal mammary tissues for the study of the intrinsic molecular subtypes (2013)

Five molecular subtypes (luminal A, luminal B, HER2-enriched, basal-like, and claudin-low) with clinical implications exist in breast cancer. Here, we evaluated the molecular and phenotypic relationships of (1) a large in vitro panel of human breast cancer cell lines (BCCLs), human mammary fibroblasts (HMFs), and human mammary epithelial cells (HMECs); (2) in vivo breast tumors; (3) normal breast cell subpopulations; (4) human embryonic stem cells (hESCs); and (5) bone marrow-derived mesenchymal stem cells (hMSC). First, by integrating genomic data of 337 breast tumor samples with 93 cell lines we were able to identify all the intrinsic tumor subtypes in the cell lines, except for luminal A. Secondly, we observed that the cell lines recapitulate the differentiation hierarchy detected in the normal mammary gland, with claudin-low BCCLs and HMFs cells showing a stromal phenotype, HMECs showing a mammary stem cell/bipotent progenitor phenotype, basal-like cells showing a luminal progenitor phenotype, and luminal B cell lines showing a mature luminal phenotype. Thirdly, we identified basal-like and highly migratory claudin-low subpopulations of cells within a subset of triple-negative BCCLs (SUM149PT, HCC1143, and HCC38). Interestingly, both subpopulations within SUM149PT were enriched for tumor-initiating cells, but the basal-like subpopulation grew tumors faster than the claudin-low subpopulation. Finally, claudin-low BCCLs resembled the phenotype of hMSCs, whereas hESCs cells showed an epithelial phenotype without basal or luminal differentiation. The results presented here help to improve our understanding of the wide range of breast cancer cell line models through the appropriate pairing of cell lines with relevant in vivo tumor and normal cell counterparts.
Increase in Oxidative Damage to Lipids and Proteins in Skeletal Muscle of Uremic Patients (2002)

Muscle weakness and reduced exercise capacity are frequent complaints of patients with chronic uremia. Several lines of evidence have suggested that chronic uremia result in a state of increased oxidative stress. Reactive oxygen species (ROS) and free radicals are capable of damaging lipids and proteins but it remains unclear whether oxidative damage plays a role in the skeletal myopathy commonly seen in chronic uremia. In this cross-sectional study, we compared the levels of oxidative damage to proteins and lipids of skeletal muscle from 40 chronic uremic patients and 20 age- and sex-matched healthy subjects. Protein carbonyls were determined by a spectrophotometric method to assess the oxidative damage to proteins. Our results showed that the mean content of protein carbonyls in skeletal muscles was significantly elevated in the hemodialysis patients (3.78+/-0.14 nmol of 2,4-dinitrophenyl-hydrazone per mg of protein) as compared to healthy controls (2.97+/-0.28 nmol per mg of protein, p = 0.017 vs normal controls). In addition, we found that the mean malondialdehyde (MDA) level was also significantly increased in the uremic patients compared to healthy controls. Further analysis revealed that there was an age-dependent increase in both oxidative damages in these patients. Regression analysis between plasma protein carbonyl and MDA levels showed a significant correlation between these two parameters (r = 0.43, p = 0.002). The finding of increased oxidative damage to protein and lipids provide support that oxidative damage may play a role in the pathogenesis of skeletal myopathy in chronic uremic patients on hemodialysis.
Fluorescence visualization of crystal formation and transformation processes of organic luminogens with crystallization-induced emission characteristics (2017)

A real-time, on-site, nondestructive, fluorescence imaging technique has been reported to monitor the crystal formation and transformation processes of organic luminogens.
Active‐passive gradient shielding for MRI acoustic noise reduction (2005)

An important source of MRI acoustic noise-magnet cryostat warm-bore vibrations caused by eddy-current-induced forces-can be mitigated by a passive metal shield mounted on the outside of a vibration-isolated, vacuum-enclosed shielded gradient set. Finite-element (FE) calculations for a z-gradient indicate that a 2-mm-thick Cu layer wrapped on the gradient assembly can decrease mechanical power deposition in the warm bore and reduce warm-bore acoustic noise production by about 25 dB. Eliminating the conducting warm bore and other magnet parts as significant acoustic noise sources could lead to the development of truly quiet, fully functioning MRI systems with noise levels below 70 dB.
ChemInform Abstract: Synthesis of Bis(oxydimethylene)tetrathiafulvalene (BODM‐TTF) and BEDSe‐TTF. (1989)

Abstract The bis(ethylenediseleno)tetrathiafulvalene (BEDSe‐TTF) (IV) is prepared by complete lithiation of the TTF (I), followed by addition of selenium (II) and quenching with 1,2‐dibromoethane (III).
Significance and Meaning of Neurological Signs in Schizophrenia: Two Decades Later (2005)

There is compelling evidence to suggest the hypothesis that neurological signs represent a trait feature of schizophrenia.
THE CONJUGATION SYSTEM OF F, THE FERTILITY FACTOR OF <i>ESCHERICHIA COLI</i> (1986)

Orthologs and paralogs are two fundamentally different types of homologous genes that evolved, respectively, by vertical descent from a single ancestral gene and by duplication. Orthology and paralogy are key concepts of evolutionary genomics. A ...Read More
Surface Energy‐Controlled SERS Substrates for Molecular Concentration at Plasmonic Nanogaps (2017)

Abstract Positioning probe molecules at electromagnetic hot spots with nanometer precision is required to achieve highly sensitive and reproducible surface‐enhanced Raman spectroscopy (SERS) analysis. In this article, molecular positioning at plasmonic nanogaps is reported using a high aspect ratio (HAR) plasmonic nanopillar array with a controlled surface energy. A large‐area HAR plasmonic nanopillar array is generated using a nanolithography‐free simple process involving Ar plasma treatment applied to a smooth polymer surface and the subsequent evaporation of metal onto the polymer nanopillars. The surface energy can be precisely controlled through the selective removal of an adsorbed self‐assembled monolayer of low surface‐energy molecules prepared on the plasmonic nanopillars. This process can be used to tune the surface energy and provide a superhydrophobic surface with a water contact angle of 165.8° on the one hand or a hydrophilic surface with a water contact angle of 40.0° on the other. The highly tunable surface wettability is employed to systematically investigate the effects of the surface energy on the capillary‐force‐induced clustering among the HAR plasmonic nanopillars as well as on molecular concentration at the collapsed nanogaps present at the tops of the clustered nanopillars.
Functional Consequences of Interactions between Human NKR-P1A and Its Ligand LLT1 Expressed on Activated Dendritic Cells and B Cells (2008)

Lectin-like transcript-1 (LLT1) (also named osteoclast inhibitory lectin or CLEC2D) is a ligand for the human NKR-P1A (CD161) receptor, present on NK cells and T cells. To further understand the physiological relevance of this interaction, we developed mAbs against LLT1, characterized the expression pattern of LLT1, and explored the functional consequence of LLT1 engagement of the NKR-P1A receptor on NK cells and T cells. LLT1 is expressed on TLR-activated plasmacytoid dendritic, TLR-activated monocyte-derived dendritic cells, and on B cells stimulated through TLR9, surface Ig, or CD40. Interactions between NKR-P1A on NK cells and LLT1 on target cells inhibit NK cell-mediated cytotoxicity and cytokine production and can inhibit TNF-alpha production by TCR-activated NKR-P1A(+) CD8(+) T cells. In contrast, NKR-P1A failed to inhibit or augment the TCR-dependent activation of NKR-P1A-bearing CD4(+) T cells. Expression of LLT1 on activated dendritic cells and B cells suggests that it might regulate the cross-talk between NK cells and APCs.
<i>In vivo</i> Bioavailability and Pharmacokinetics of a <i>c-MYC</i> Antisense Phosphorodiamidate Morpholino Oligomer, AVI-4126, in Solid Tumors (2005)

Phosphorodiamidate morpholino oligomers (PMO) inhibit targeted gene expression by preventing ribosomal assembly, thereby preventing mRNA translation. AVI-4126, a PMO targeted against c-MYC, has been extensively characterized in multiple cancer and other disease models and is currently in human clinical trials. A phase I clinical study was conducted to address the issue of PMO bioavailability in malignant tumors surgically excised from patients with adenocarcinoma of prostate and breast 1 day after i.v. administration of a single dose of 90 mg AVI-4126 PMO. The study objectives were to evaluate safety, to determine AVI-4126 concentration in tissue samples of the tumors, and to examine the distribution of AVI-4126 (margin versus tumor core). Significant concentrations of intact PMO similar to the animal models were detected in both human prostate and breast tumor tissues with increased distribution in the tumor core for the vascular breast tumors. No serious adverse events (graded according to National Cancer Institute Common Toxicity Criteria) were reported. Another phase I study was conducted in normal human volunteers to assess AVI-4126 plasma pharmacokinetics following single i.v. administration of 90 mg AVI-4126. Data from both human studies indicated similar plasma concentration-time profile. These studies show PMO bioavailability in tumor tissue and establish the feasibility of using PMO targeting specific genes in human cancer clinical trials.
The Development of the Academy of Wine Service (1993)

The Academy of Wine service was founded in 1988 to raise the standard of education and skills in the service of wine in the hotel, restaurant and catering industry. In September 1991, the Academy launched its ‘Professional Wine Service Training Package’, which was specifically designed to satisfy waiters' wide‐ranging needs and time constraints. The programme provides a single, open and flexible learning package to develop trainees competence and thus help them secure a national vocational qualification (NVQ). Following extensive field trials, the success of the Traning Package is clear to see: volume sales and average spend per head rose substantially, with sales up +18% in participating Forte Hotels and +16% in participating independent hotels and the investment in training was recovered with an avarage 15 weeks. Additionally, the Academy of Wine Service has organised an annual programme of tutored tastings, produced a bi‐monthly newsletter, “Wine Line”, set up awards, scholarships and national competitions, and expanded its membership benefits. Five years on, The Academy of Wine Service is now recognised as the national education and training authority for professional wine service and is now being developed into The Academy of Food & Wine Service to provide a total training package for the entire industry by the beginning of 1994.
12/7 and 9/11: War, Liberties, and the Lessons of History (2002)

In this essay, originally presented as the Edward G. Donley Memorial Lecture at the West Virginia University College of Law in February, 2002, Muller compares the Roosevelt administration's domestic policies affecting Japanese Americans after the attack on Pearl Harbor with the Bush administration's domestic policies affecting people of Arab ancestry and Muslim faith after the September 11 attacks on the World Trade Center and the Pentagon. U.S. Supreme Court Justice Robert Jackson, dissenting in the 1944 Korematsu case, predicted that the Court's opinion upholding the eviction of 120,000 Japanese Americans from the West Coast would lie about like a loaded weapon, threatening future generations. Canvassing the Bush administration's post-September 11 policies touching on race and ethnicity, Muller finds a healthy measure of restraint - a significantly greater measure of restraint than the Roosevelt administration showed in the days after Pearl Harbor, and, more interestingly, a significantly greater measure of restraint than has marked the Bush administration's post-9/11 policies that do not touch on race and ethnicity. Muller challenges the oft-heard assertion that the Bush administration's policies repeat the mistake of Korematsu, and speculates that recent events may show that the racist assumptions that underlay the Roosevelt administration's policies have been pushed to, or even beyond, the fringes of acceptable policy discourse, even in times of crisis.
<b>Bruce Western, </b><b> <i>Between Class and Market: Postwar Unionization in the Capitalist Democracies.</i> </b> Princeton, NJ: Princeton University Press, 1997. ix + 230 pp. $45.00 paper. (1999)

For a century after 1870, labor unions and working-class political movements grew steadily in virtually all industrialized capitalist economies. By the late 1970s, unions enrolled 40 percent of the total labor force in Germany and New Zealand; 50 percent in Australia, Italy, and the United Kingdom; over 60 percent in Austria, Belgium, Denmark, and Norway; and over 80 percent in Finland and Sweden (24). In addition, unions' political allies held important political offices in many of these countries, including control of the government in Germany, the United Kingdom, Italy, and Scandinavia.
Regulation of the expression of the L-type pyruvate kinase gene in adult rat hepatocytes in primary culture (1989)

Hepatocytes isolated from adult fasted rats and cultured in the presence of thyroid hormones, glucocorticoids, and in a serum-free medium conserve the essentials of their differentiated function and hormonal sensitivity for at least 1 week. In these cells, the gene for L-type pyruvate kinase is expressed only when glucose and insulin are present together, each of them being inactive by itself. Inhibition of the expression of the L-type pyruvate kinase gene which occurs when glucose and/or insulin are removed from the culture medium is not associated with accumulation of the phosphoenolpyruvate carboxykinase mRNA, which argues against the involvement of intracellular cyclic AMP in this phenomenon. Rather, a transcriptional activator, derived from carbohydrate metabolism and accumulating in the presence of insulin, seems to be needed to support the expression of the L-type pyruvate kinase gene. Glucagon, in vitro as in vivo, inhibits production of the L-type pyruvate kinase mRNAs. In addition to their roles on the production of these mRNAs, glucose and insulin on the one hand and glucagon on the other have profound effects on the stability of the L-type pyruvate kinase messengers: the half-life of the mRNA whose production has been blocked by actinomycin D is 1 h in the presence of glucagon and 24 h in the presence of glucose and insulin. Glucagon and glucose/insulin partially antagonize each other's effect on mRNA stability.
Field emission from diamond coated molybdenum field emitters (1996)

Diamond deposition onto single Mo field emitters was accomplished by two methods: microwave plasma chemical vapor deposition and a dielectrophoresis of diamond powder. Observation by transmission electron microscopy and scanning electron microscopy revealed a significant amount of deposition at the tips. The field emission characteristics were measured before and after diamond deposition on the same emitters. Field emission from diamond coated emitters yielded significant increases in emission current and lower Fowler–Nordheim slopes. We discuss a possible mechanism to explain current enhancement that depends primarily upon the Mo-diamond interface.
Transformation of interleukin-3–dependent cells without participation of Stat5/bcl-xL: cooperation of akt with raf/erk leads to p65 nuclear factor κB–mediated antiapoptosis involving c-IAP2 (2001)

Tyrosine kinase oncogenes such as p210BCR-ABL activate multiple signal pathways. As a result, it is difficult to infer the functional relevance of a pathway acting alone or in cooperation with another. One or 2 second-tier kinases represented in the p21ras and phosphatidylinositol-3-kinase (PI-3-kinase) pathways (activated RafCAAX and gag-akt, respectively) were expressed in parental H7 interleukin-3 (IL-3)-dependent myeloid cells. IL-3-dependent cells served, independently, as recipients of p210BCR-ABL, which activated p21ras and PI-3-kinase pathways, including raf/erk and akt, respectively, en route to transformation. By contrast, neither RafCAAX nor gag-akt when expressed in parental cells in isolation produced factor-independent cells. On the other hand, H7 cells expressing both RafCAAX and gag-akt (H7gag-akt/RafCAAX) were transformed. Such transformation in H7gag-akt/RafCAAX was accomplished in the absence of active versions of Shc or cbl, and there was no evidence of Stat activity and only modest amounts of bcl-xL, a Stat5 transcriptional target protein, all of which characterized the cells transformed by BCR-ABL. However, H7gag-akt/RafCAAX cells and H7BCR-ABL cells cultured in the absence of IL-3 shared strikingly increased p65 nuclear factor kappaB (NFkappaB) activity. Treatment of cells with a specific NFkappaB inhibitor, parthenolide, led to loss of NFkappaB activity and down-regulation of antiapoptotic c-IAP2. In cells with only gag-akt/RafCAAX, this was sufficient to allow polyADP ribosyltransferase (PARP)-degradative apoptosis, but in cells with p210BCR-ABL, apoptosis was blocked, possibly by a Stat5/bcl-xL-dependent mechanism. Therefore, one hematopoietic antiapoptotic program, among others, available to certain tyrosine kinase oncogenes involves a cooperative response between raf/erk and akt, unambiguous components of p21ras and PI-3-kinase pathways, to induce p65 NFkappaB and c-IAP2.
Pancreatic Cancer Risk and ABO Blood Group Alleles: Results from the Pancreatic Cancer Cohort Consortium (2010)

A recent genome-wide association study (PanScan) identified significant associations at the ABO gene locus with risk of pancreatic cancer, but the influence of specific ABO genotypes remains unknown. We determined ABO genotypes (OO, AO, AA, AB, BO, and BB) in 1,534 cases and 1,583 controls from 12 prospective cohorts in PanScan, grouping participants by genotype-derived serologic blood type (O, A, AB, and B). Adjusted odds ratios (ORs) for pancreatic cancer by ABO alleles were calculated using logistic regression. Compared with blood type O, the ORs for pancreatic cancer in subjects with types A, AB, and B were 1.38 [95% confidence interval (95% CI), 1.18-1.62], 1.47 (95% CI, 1.07-2.02), and 1.53 (95% CI, 1.21-1.92), respectively. The incidence rates for blood types O, A, AB, and B were 28.9, 39.9, 41.8, and 44.5 cases per 100,000 subjects per year. An increase in risk was noted with the addition of each non-O allele. Compared with OO genotype, subjects with AO and AA genotype had ORs of 1.33 (95% CI, 1.13-1.58) and 1.61 (95% CI, 1.22-2.18), whereas subjects with BO and BB genotypes had ORs of 1.45 (95% CI, 1.14-1.85) and 2.42 (1.28-4.57). The population attributable fraction for non-O blood type was 19.5%. In a joint model with smoking, current smokers with non-O blood type had an adjusted OR of 2.68 (95% CI, 2.03-3.54) compared with nonsmokers of blood type O. We concluded that ABO genotypes were significantly associated with pancreatic cancer risk.
γ-Valerolactone—a sustainable liquid for energy and carbon-based chemicals (2007)

We propose that γ-valerolactone (GVL), a naturally occurring chemical in fruits and a frequently used food additive, exhibits the most important characteristics of an ideal sustainable liquid, which could be used for the production of both energy and carbon-based consumer products. GVL is renewable, easy and safe to store and move globally in large quantities, has low melting (−31 °C), high boiling (207 °C) and open cup flash (96 °C) points, a definitive but acceptable smell for easy recognition of leaks and spills, and is miscible with water, assisting biodegradation. We have established that its vapor pressure is remarkably low, even at higher temperatures (3.5 kPa at 80 °C). We have also shown by using 18O-labeled water that GVL does not hydrolyze to gamma-hydroxypentanoic acid under neutral conditions. In contrast, after the addition of acid (HCl) the incorporation of one or two 18O-isotopes to GVL was observed, as expected. GVL does not form a measurable amount of peroxides in a glass flask under air in weeks, making it a safe material for large scale use. Comparative evaluation of GVL and ethanol as fuel additives, performed on a mixture of 10 v/v% GVL or EtOH and 90 v/v% 95-octane gasoline, shows very similar properties. Since GVL does not form an azeotrope with water, the latter can be readily removed by distillation, resulting in a less energy demanding process for the production of GVL than that of absolute ethanol. Finally, it is also important to recognize that the use of a single chemical entity, such as GVL, as a sustainable liquid instead of a mixture of compounds, could significantly simplify its worldwide monitoring and regulation.
Dynamically changing the logical behavior of the microcomputer interface (1989)

Industrial programmable controllers and hardware simulators currently use the software method of direct logic simulation. In this method, programs contain the logical functions of several Boolean variables that are encoded directly. Each combinational circuit expressed by a group of Boolean equations requires an independent program. An alternative solution for the software implementation of the Boolean equations, named the product terms method, is presented. This method features the use of a single program to implement any multiple-output combinational circuit. To make the distinction between different circuits, a block of data defines each circuit. The product method is extended to synchronous sequential circuits, for which two tables are used. One table determines the next state of the combinational circuit, and the second table determines the outputs. An expert system has been developed to generate the table used in the product terms by interpreting the symbolic Boolean equations supplied by the user. The implementation and testing of the method are described.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>