gebhart/patrepeval huggingface dataset:
CD44v3,8-10 is involved in cytoskeleton-mediated tumor cell migration and matrix metalloproteinase (MMP-9) association in metastatic breast cancer cells (1998)

In the present study, we have employed a unique breast cancer cell line (Met-1, which was derived from a high metastatic potential tumor in transgenic mice expressing polyomavirus middle T oncogene) to study the role of CD44 variant isoform(s) in the regulation of metastatic breast tumor cell behavior. The results of reverse transcriptase-polymerase chain reaction, Southern blot, nucleotide sequencing, immunoprecipitation, and immunoblot analyses indicated that these cells express a major CD44 isoform (molecular weight approximately 260 kDa) containing a v3,8-10 exon insertion (designated as CD44v3,8-10). In addition, we have determined that CD44v3,8-10 binds specifically to the cytoskeletal proteins such as ankyrin. Biochemical analyses, using competition binding assays and a synthetic peptide identical to NGGNGTVEDRKPSEL (a sequence located between aa480 and aa494 of CD44v3,8-10) indicate that this 15-amino acid peptide binds specifically to the cytoskeletal protein ankyrin (but not to fodrin or spectrin). This peptide competes effectively for ankyrin binding to CD44v3,8-10. Therefore, we believe that the sequence 480NGGNGTVEDRKPSE494L, located at the cytoplasmic domain of CD44v3,8-10, is required for the ankyrin binding. We have also detected that CD44v3,8-10-containing Met-1 cells are capable of forming membrane spikes or "invadopodia" structures and undergo active migration processes. Treatments of Met-1 cells with certain agents including anti-CD44v3 antibody, cytochalasin D (a microfilament inhibitor), and W-7 (a calmodulin antagonist), but not colchicine (a microtubule disrupting agent) effectively inhibit "invadopodia" formation and subsequent tumor cell migration. Further analyses using zymography assays and double immunofluorescence staining indicated that CD44v3,8-10 is closely associated with the active form of matrix metalloproteinase, MMP-9, in a complex within "invadopodia" structures. These findings suggest that CD44v3,8-10 plays an important role in linking ankyrin to the membrane-associated actomyosin contractile system required for "invadopodia" formation (coupled with matrix degradation activities) and tumor cell migration during breast cancer progression.
Cool plasma for large scale chemical-free microbial inactivation of surfaces (2008)

A new process for microbial inactivation of food surfaces is based on microwave generated plasma. Microbial inactivation results reported in the literature so far are exciting, but most were obtained from laboratory plasma devices which cannot be easily scaled up. A one metre long microwave cool plasma demonstration unit uses magnetrons commonly found in microwave ovens. Using this design, plasma lines of various lengths can be used to build plasma arrays for large scale, chemical-free, microbial inactivation. In preliminary trials, Bacillus subtilis was inactivated to better than a 5.2 log reduction on a glass surface in 6 s exposure to microwave plasma and Staphylococcus aureus to a 3.7 log reduction. The future challenge is to achieve microbial inactivation on food products, wet surfaces or uneven surfaces such as paper.
Electrically small self-resonant wire antennas optimized using a genetic algorithm (2002)

One of the major limitations of electrically small antennas is that as the size of the antenna is decreased its radiation resistance approaches zero and its reactance approaches plus or minus infinity. Most small antennas are inefficient, nonresonant and, thus, require matching networks. In this investigation, we use a genetic algorithm (GA) in conjunction with the numerical electromagnetics code to search for resonant wire shapes that best utilize the volume within which the antenna is confined. Antenna configurations, over a ground plane, having from two to ten wire segments, were optimized near 400 MHz and then built and tested. As the cube size deceased from a side length of 0.096/spl lambda/ to 0.026/spl lambda/, the computed Qs increased from 15.8 to 590. The measured Qs increased from 16.0 to 134 for cubes of 0.093 to 0.037/spl lambda/ on edge. This process for designing small antennas using a GA produced new self-resonant antenna configurations.
Loss of N-myc function results in embryonic lethality and failure of the epithelial component of the embryo to develop. (1992)

myc genes are thought to function in the processes of cellular proliferation and differentiation. To gain insight into the role of the N-myc gene during embryogenesis, we examined its expression in embryos during postimplantation development using RNA in situ hybridization. Tissue- and cell-specific patterns of expression unique to N-myc as compared with the related c-myc gene were observed. N-myc transcripts become progressively restricted to specific cell types, primarily to epithelial tissues including those of the developing nervous system and those in developing organs characterized by epithelio-mesenchymal interaction. In contrast, c-myc transcripts were confined to the mesenchymal compartments. These data suggest that c-myc and N-myc proteins may interact with different substrates in performing their function during embryogenesis and suggest further that there are linked regulatory mechanisms for normal expression in the embryo. We have mutated the N-myc locus via homologous recombination in embryonic stem (ES) cells and introduced the mutated allele into the mouse germ line. Live-born heterozygotes are under-represented but appear normal. Homozygous mutant embryos die prenatally at approximately 11.5 days of gestation. Histologic examination of homozygous mutant embryos indicates that several developing organs are affected. These include the central and peripheral nervous systems, mesonephros, lung, and gut. Thus, N-myc function is required during embryogenesis, and the pathology observed is consistent with the normal pattern of N-myc expression. Examination of c-myc expression in mutant embryos indicates the existence of coordinate regulation of myc genes during mouse embryogenesis.
Stemming vision loss with stem cells (2010)

Dramatic advances in the field of stem cell research have raised the possibility of using these cells to treat a variety of diseases. The eye is an excellent target organ for such cell-based therapeutics due to its ready accessibility, the prevalence of vasculo-and neurodegenerative diseases affecting vision, and the availability of animal models to demonstrate proof of concept. In fact, stem cell therapies have already been applied to the treatment of disease affecting the ocular surface, leading to preservation of vision. Diseases in the back of the eye, such as macular degeneration, diabetic retinopathy, and inherited retinal degenerations, present greater challenges, but rapidly emerging stem cell technologies hold the promise of autologous grafts to stabilize vision loss through cellular replacement or paracrine rescue effects.
Observing real smartphone applications over multipath TCP (2016)

A large fraction of smartphones have both cellular and WiFi interfaces. Despite this, smartphones rarely use them simultaneously because most of their data traffic is controlled by TCP, which can only use one interface at a time. Multipath TCP is a recently standardized TCP extension that solves this problem. Smartphone vendors have started to deploy Multipath TCP, but its performance with real smartphone applications has not been studied in detail yet. To fill this gap, we port Multipath TCP on Android smartphones, and propose a framework to analyze the interactions between real network-heavy applications and this new protocol. We use eight popular Android applications and analyze their usage of the WiFi and cellular networks (especially 4G/LTE).
Laser Initiated Free-Radical Reactions (1984)

We present the experimental results of three laser initiated free-radical reactions. As one might expect, each reaction exhibits a wavelength dependence, but the mechanisms for each are not intuitively obvious. In all three examples, photochemical induction followed by thermal propagation results in higher conversions with fewer by-products when compared to strictly thermal synthetic routes.
Topological composition systems: specifications for lexical elements of visual languages (2002)

The paper explains the role of lexical analysis in a visual programming environment. The authors classify the visual lexical elements based on the geometric properties of their composition operators. They explore the class of topologically composed lexical elements and provide a method of specifying them. They refer to these specifications as topological composition systems. The core of such a system is a set of composition rules that define the topological compositions to be performed and the conditions when the rules can be fired. They also describe the design of a lexical analyzer for topological composition systems. The design uses efficient computational geometry algorithms to achieve a time complexity of O( mod R mod N log N) for an input size of N primitive picture elements, where mod R mod is the number of rules in the system. A lexical analysis phase, preceding parsing, can reduce the input size to the parser by 30%-50%. Early experiments also show that using topological lexical analysis can enhance the overall picture recognition process performance by a factor of 10.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Exploiting frequent field values in java objects for reducing heap memory requirements (2005)

The capabilities of applications executing on embedded and mobile devices are strongly influenced by memory size limitations. In fact, memory limitations are one of the main reasons that applications run slowly or even crash in embedded/mobile devices. While improvements in technology enable the integration of more memory into embedded devices, the amount memory that can be included is also limited by cost, power consumption, and form factor considerations. Consequently, addressing memory limitations will continue to be of importance.Focusing on embedded Java environments, this paper shows how object compression can improve memory space utilization. The main idea is to make use of the observation that a small set of values tend to appear in some fields of the heap-allocated objects much more frequently than other values. Our analysis shows the existence of such frequent field values in the SpecJVM98 benchmark suite. We then propose two object compression schemes that eliminate/reduce the space occupied by the frequent field values. Our extensive experimental evaluation using a set of eight Java benchmarks shows that these schemes can reduce the minimum heap size allowing Java applications to execute without out-of-memory exceptions by up to 24% (14% on an average).
Oxygen Promoted Addition of 1,3-Dioxolane to Electron-deficient Alkenes (1983)

Abstract 1,3-Dioxolane reacted with electron-deficient alkenes, such as diethyl maleate, maleic anhydride, diethyl fumarate and fumaronitrile, under an oxygen atmosphere or in air to give 1:1 adducts in good to excellent yields. The presence of oxygen promoted the reaction. The reaction appears to be characteristic of 1,3-dioxolane. Methylal and ethylal did not react with diethyl maleate under the same conditions.
50‐Fold EQE Improvement up to 6.27% of Solution‐Processed All‐Inorganic Perovskite CsPbBr<sub>3</sub> QLEDs via Surface Ligand Density Control (2016)

Solution-processed CsPbBr<sub>3</sub> quantum-dot light-emitting diodes with a 50-fold external quantum efficiency improvement (up to 6.27%) are achieved through balancing surface passivation and carrier injection via ligand density control (treating with hexane/ethyl acetate mixed solvent), which induces the coexistence of high levels of ink stability, photoluminescence quantum yields, thin-film uniformity, and carrier-injection efficiency.
Potential Treatment of Parkinson’S Disease Using New-Generation Carbon Nanotubes: A Biomolecular <i>In Silico</i> Study (2021)

<b>Background:</b> One of the underlying mechanisms of Parkinson's disease is the aggregation of α-synuclein proteins, including amyloids and Lewy bodies in the brain. <b>Aim:</b> To study the inhibitory effect of doped carbon nanotubes (CNTs) on amyloid aggregation. <b>Materials & methods:</b> Molecular dynamics tools were utilized to simulate the influence of CNTs doped with phosphorus, nitrogen and bromine and nitrogen on the formation of α-synuclein amyloid. <b>Results:</b> The CNTs exhibited strong interactions with α-synuclein, with phosphorus-doped CNTs having the most substantial interactions. <b>Conclusion:</b> Doped-CNTs, especially phosphorus-doped carbon nanotube could effectively prevent α-synuclein amyloid formation, thus, it could be considered as a potential treatment for Parkinson's disease. However, further <i>in vitro</i> and clinical investigations are required.
<title>Increased productivity through Modeltime behaviors</title> (1995)

Recent attention has been focused on the assignment of behaviors to graphical entities. Most of these behaviors are targeted for the runtime environment. By defining modeltime<SUP>TM</SUP> behaviors, behaviors whose sole purpose is to help with the task of modeling and whose scope is limited to the modeling environment itself, great gains in productivity can be realized in rapid assembly tasks.
Smiles, Babies, and Status Symbols: The Persuasive Effects of Image Choices in Small-Entrepreneur Crowdfunding Requests (2016)

This article examines the persuasive effects of images in the context of online peer-to-peer microfinance. The theoretical framework—based in self-presentation and impression management—relates micro-entrepreneurs’ loan-request image choices to lending decisions and lenders’ perceptions of the borrower’s trustworthiness and need. We explore effects of three specific visuals: (1) genuine enjoyment (Duchenne) smiles; (2) material status symbols; and (3) babies, children, and husbands. Using loan-request image data from 323 women micro-entrepreneurs on the Kiva.org website, results suggest smiling behavior is not associated with funding speed. However, loan-request images that include a baby are associated with significantly quicker funding, and those that include a man or an indication of relative material well-being are associated with delays in the average funding speed.
Reduction of fiber alignment shifts in high-speed laser module packaging (2004)

The post-weld-shift (PWS) induced fiber alignment shifts of fiber ferrule-clip (FFC) joints in high-speed butterfly laser packaging by laser welding technique has been studied experimentally and numerically. There are two types of clip design in the FFC joint: the type I design is without a gap between clip and fiber ferrule and type II is a 5 /spl mu/m gap. Using a novel 230/spl times/ high magnification video probe camera with image acquisition system, the measured results showed that the fiber shifts of FFC joints with the type II exhibited shifts less than that with the type I. The experimental measurements of fiber shifts were in reasonable agreement with the numerical calculations of the finite-element method (FEM) analysis. This study has demonstrated that the FEM is an effective method for predicting PWS induced fiber alignment shifts in laser module packaging.
Orderly hematopoietic development of induced pluripotent stem cells via Flk‐1<sup>+</sup> hemoangiogenic progenitors (2009)

Induced pluripotent stem (iPS) cells, reprogrammed somatic cells with embryonic stem (ES) cell-like characteristics, are generated by the introduction of combinations of specific transcription factors. Little is known about the differentiation of iPS cells in vitro. Here we demonstrate that murine iPS cells produce various hematopoietic cell lineages when incubated on a layer of OP9 stromal cells. During this differentiation, iPS cells went through an intermediate stage consisting of progenitor cells that were positive for the early mesodermal marker Flk-1 and for the sequential expression of other genes that are associated with hematopoietic and endothelial development. Flk-1(+) cells differentiated into primitive and definitive hematopoietic cells, as well as into endothelial cells. Furthermore, Flk-1(+) populations contained common bilineage progenitors that could generate both hematopoietic and endothelial lineages from single cells. Our results demonstrate that iPS cell-derived cells, like ES cells, can follow a similar hematopoietic route to that seen in normal embryogenesis. This finding highlights the potential use of iPS cells in clinical areas such as regenerative medicine, disease investigation, and drug screening.
Comparing Dynamic Hyperinflation and Associated Dyspnea Induced by Metronome-Paced Tachypnea Versus Incremental Exercise (2013)

Dynamic hyperinflation (DH) during exercise is associated with both dyspnea and exercise limitation in COPD. Metronome-paced tachypnoea (MPT) is a simple alternative for studying DH. We compared MPT with exercise testing (XT) as methods of provoking DH, and assessed their relationship with dyspnea. We studied 24 patients with moderate COPD (FEV1 59 ± 9% predicted) after inhalation of ipratropium/salbutamol combination or placebo in a double-blind, crossover design. Inspiratory capacity (IC) was measured at baseline and after 30 seconds of MPT with breathing frequencies (fR) of 20, 30 and 40 breaths/min and metronome-defined I:E ratios of 1:1 and 1:2, in random sequence, followed by incremental cycle ergometry with interval determinations of IC. DH was defined as a decline in IC from baseline (∆IC) for both methods. Dyspnea was assessed using a Borg CR-10 scale. ∆IC during MPT was greater with higher fR and I:E ratio of 1:1 versus 1:2, and less when patients were treated with bronchodilator rather than placebo (P = 0.032). DH occurred during 19 (40%) XTs, and during 35 (73%) tests using MPT. Eleven of 18 (61%) non-congruent XTs (where DH occurred on MPT but not XT) terminated before fR of 40 breaths/min was reached. Although greater during XT, the intensity of dyspnea bore no relationship to DH during either MPT and XT. MPT at 40 breaths/min and I:E of 1:1 elicits the greatest ∆IC, and is a more sensitive method for demonstrating DH. The relationship between DH and dyspnea is complex and not determined by DH alone.
Programmable dispersion matrix using Bragg fibregrating for optically controlled phased array antennas (1996)

A programmable dispersion matrix implemented with Bragg fibre gratings is demonstrated in conjunction with a multiwavelength laser source for use in optically controlled phased array antennas. Relative time delays are experimentally measured using a prototype programmable dispersion matrix with 2 bit resolution and the results agree well with the theoretical prediction.
Ammoniation of Sulfite Waste Liquor (1936)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAmmoniation of Sulfite Waste LiquorKenneth A. Kobe, Jack H. Layman, and Frederick R. ArmbrusterCite this: Ind. Eng. Chem. 1936, 28, 5, 571–572Publication Date (Print):May 1, 1936Publication History Published online1 May 2002Published inissue 1 May 1936https://pubs.acs.org/doi/10.1021/ie50317a017https://doi.org/10.1021/ie50317a017research-articleACS PublicationsRequest reuse permissionsArticle Views11Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Social Science and Society - ahead of, or behind, Science and Society? (2008)

TIVAD placement by the SV percutaneous approach is safe and fast, and its success rate is very high. By avoiding the immediate complications associated with the percutaneous approach, the EJV cutdown has to be considered a valid, safe, and suitable alternative when the SV percutaneous approach unsuccessful after two needle puncture.
109. Chemical examination of Wedelia calendulacea. Part III. Synthesis of tri-O-methylwedelolactone (1957)

T. R. Govindachari, K. Nagarajan and P. C. Parthasarathy, J. Chem. Soc., 1957, 548 DOI: 10.1039/JR9570000548
Trends in fruit and vegetable consumption among U.S. men and women, 1994-2005. (2008)

INTRODUCTION: Eating a diet high in fruits and vegetables as part of an overall healthful diet can help lower chronic disease risk and aid in weight management. Increasing the percentage of Americans who consume enough fruits and vegetables every day is part of the Healthy People 2010 objectives for the nation. Assessing trends in consumption of these foods is important for tracking public health initiatives to meet this goal and for planning future objectives. METHODS: We assessed total and sex-specific changes in daily consumption of fruits and vegetables among 1,227,969 adults in the 50 U.S. states and the District of Columbia who participated in the Behavioral Risk Factor Surveillance System from 1994 through 2005. To estimate changes in consumption according to dietary recommendations that were in place during the years examined, we used geometric mean and the percentage of people eating fruits or vegetables or both five or more times per day. Estimates were standardized for sex, age, and race/ethnicity and analyzed by multivariate regression. RESULTS: From 1994 through 2005, the geometric mean frequency of consumption of fruits and vegetables declined slightly (standardized change: men and women, −0.22 times/day; men, −0.26 times/day; women, −0.17 times/day). The proportion of men and women eating fruits or vegetables or both five or more times per day was virtually unchanged (men, 20.6% vs 20.3%; women, 28.4% vs 29.6%); however, we found small increases for men aged 18 to 24 years and for women who were aged 25 to 34 years, non-Hispanic black, or nonsmokers. Consumption of fruit juice and nonfried potatoes declined for both sexes. CONCLUSION: The frequency of fruit and vegetable consumption changed little from 1994 through 2005. If consumption is to be increased, we must identify and disseminate promising individual and environmental strategies, including policy change.
Joyce Trebilcot: Member of the Ancient and Honorable Society of Outsiders On the Occasion of the Publication of <i>Dyke</i> Ideas and of Her Retirement from Teaching at Washington University in St. Louis (1995)

In 1994, Joyce Trebilcot retired from teaching at Washington University in St. Louis, where she had founded the Women's Studies Program and had been a member of the Philosophy Department since 1970. In the Fall of 1994 I participated on a SWIP conference panel on her book Dyke Ideas (Trebilcot 1994) conference; I used that occasion also to reminisce and place her work in the context of her life as a SWIP activist. 1 What follows is adapted from that presentation.
Cerebral Oxygenation During Hypoxia and Resuscitation by Using Near-infrared Spectroscopy in Newborn Piglets (2007)

Noninvasive monitoring of rScO2 and evaluating FTOE changes during hypoxia and resuscitation may help clinicians evaluate brain tissue oxygenation and viability.