gebhart/patrepeval huggingface dataset:
Muscarinic stimulation of tracheal smooth muscle cells activates large-conductance Ca<sup>2+</sup>-dependent K<sup>+</sup> channel (1997)

Pages C658-C665: G. R. Wade and S. M. Sims. “Muscarinic stimulation of tracheal smooth muscle cells activates large-conductance Ca2+-dependent K+ channel.” Page C662, Fig. 6: the second half of the trace in A was inadvertently duplicated from B. The revised Fig. 6 below shows the correct channel traces. We wish to emphasize that the scientific point of the figure, the reversible antagonism of the cholinergic response by atropine, as well as the quantification in D, remains sound. The data were filtered at 400 Hz and sampled off-line from digital videotape at 2 kHz. (See PDF)
New therapy targeting differential androgen receptor signaling in prostate cancer stem/progenitor vs. non-stem/progenitor cells (2012)

The androgen deprivation therapy (ADT) to systematically suppress/reduce androgens binding to the androgen receptor (AR) has been the standard therapy for prostate cancer (PCa); yet, most of ADT eventually fails leading to the recurrence of castration resistant PCa. Here, we found that the PCa patients who received ADT had increased PCa stem/progenitor cell population. The addition of the anti-androgen, Casodex, or AR-siRNA in various PCa cells led to increased stem/progenitor cells, whereas, in contrast, the addition of functional AR led to decreased stem/progenitor cell population but increased non-stem/progenitor cell population, suggesting that AR functions differentially in PCa stem/progenitor vs. non-stem/progenitor cells. Therefore, the current ADT might result in an undesired expansion of PCa stem/progenitor cell population, which explains why this therapy fails. Using various human PCa cell lines and three different mouse models, we concluded that targeting PCa non-stem/progenitor cells with AR degradation enhancer ASC-J9 and targeting PCa stem/progenitor cells with 5-azathioprine and γ-tocotrienol resulted in a significant suppression of the tumors at the castration resistant stage. This suggests that a combinational therapy that simultaneously targets both stem/progenitor and non-stem/progenitor cells will lead to better therapeutic efficacy and may become a new therapy to battle the PCa before and after castration resistant stages.
Structure of NADH peroxidase from Streptococcus faecalis 10C1 refined at 2.16 A resolution. (1991)

The crystal structure of NADH peroxidase (EC 1.11.1.1) from Streptococcus faecalis 10C1 (Enterococcus faecalis) has been refined to a resolution of 2.16 A using the simulated annealing method. The final crystallographic R-factor is 17.7% for all data in the resolution range 7 to 2.16 A. The standard deviations are 0.015 A in bond lengths and 3.0 degrees in bond angles for the final model, which includes all 447 amino acid residues, one FAD and 369 water molecules. The enzyme is a symmetrical tetramer with point group D2; the symmetry is crystallographic. The redox center of the enzyme consists of FAD and a cysteine (Cys42), which forms a sulfenic acid (Cys-SOH) in its oxidized state. A histidine (His10) close to Cys42 is likely to act as an active-site base. In the analyzed crystal, the enzyme was in a non-native oxidation state with Cys42 oxidized to a sulfonic acid Cys-SO3H. The chain fold of NADH peroxidase is similar to those of disulfide oxidoreductases. A comparison with glutathione reductase, a representative of this enzyme family, is given.
Fast and precise positioning of wheeled Omni-directional robot with input delay using model-based predictive control (2014)

In dynamic environments, Omni-directional mobile robots sometimes are required to accomplish accurate and stable tracking of trajectories, but rare researches are addressed in the literature, which specifically deal with time-delay phenomenon. In order to cope with such situation, the trajectory tracking of an Omni-directional mobile robot is handled by model predictive control in presence of input-delay. The main innovation of this work is that MPC controller is employed to the end of trajectory. Hence, a significant reduction is yielded in the time of robot motion. This strategy forces that MPC method uses nearly good model approximation in which, the model deficiency can be compensated by modifying the novel kinematic model for robot. Furthermore, in this study, the proposed controller is compared with PID controller that achieve about 40% enhancement in amount of time to reach target and also results in to the more precise robot control in target point error.
Surface polaritons and extinction properties of a left-handed material cylinder (2004)

The dispersion curves of the surface polaritons of a cylinder which is made of a material with dispersive permittivity and permeability, and which is left-handed over a frequency band, are calculated. It is found that there exist three surface mode bands. With increasing wavevector the three bands converge to three limiting frequencies, which are equal to the three corresponding frequencies obtained for the slab geometry. The extinction properties of the cylinder are derived, and the dependence of the extinction spectrum on the cylinder radius is investigated.
Ultraviolet resonance Raman characterization of photochemical transients of phenol, tyrosine, and tryptophan (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTUltraviolet resonance Raman characterization of photochemical transients of phenol, tyrosine, and tryptophanCraig R. Johnson, Michael. Ludwig, and Sanford A. AsherCite this: J. Am. Chem. Soc. 1986, 108, 5, 905–912Publication Date (Print):March 1, 1986Publication History Published online1 May 2002Published inissue 1 March 1986https://doi.org/10.1021/ja00265a010Request reuse permissionsArticle Views822Altmetric-Citations143LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alertsclose Get e-Alerts
MALT FLAVOUR - TRANSFORMATION OF CARBONYL COMPOUNDS BY YEAST DURING FERMENTATION (1981)

Laboratory and pilot scale fermentations have been carried out using worts spiked with a range of carbonyl compounds, many of which are derived from malt. Aldehydes and vinyl ketones were chemically reduced during fermentation and could not be detected in the resulting beers; on the other hand certain saturated and non-conjugated unsaturated ketones were only partially reduced. The corresponding saturated alcohols and acetate esters were usually detected as transformation products.
Intravascular Ultrasound Assessment of the Mechanisms and Predictors of Restenosis Following Coronary Angioplasty. (1996)

Restenosis occurs after 30% to 50% of transcatheter coronary procedures; its mechanisms remain incompletely understood. Intravascular ultrasound (IVUS) studies were analyzed in 360 nonstented native coronary artery lesions in which follow-up quantitative angiographic and/or IVUS data was available. Pre-intervention, post-intervention, and follow-up, the external elastic membrane (EEM) and lumen cross-sectional areas (CSA) were measured; plaque+media (P+M=EEM Ð lumen CSA), and cross-sectional narrowing (CSN=P+M/EEM CSA) were calculated. The anatomic slice selected for serial analysis had an axial location within the lesion at the smallest follow-up lumen CSA. At follow-up, 73% of the decrease in lumen CSA was due to a decrease in EEM CSA; 27% was due to an increase in P+M CSA. The change in lumen CSA correlated more strongly with the change in EEM CSA than with the change in P+M CSA. The change in EEM CSA was bidirectional; 47 lesions (22%) showed an increase in EEM CSA. Despite a greater increase in P+M CSA, lesions exhibiting an increase in EEM CSA had (1) no change in lumen CSA, (2) decreased restenosis, and (3) a 49% frequency of late lumen gain. The independent clinical, angiographic, and IVUS predictors of angiographic restenosis (³ 50% diameter stenosis at follow-up) were the IVUS reference lumen CSA, angiographic pre-intervention diameter stenosis, and post-intervention IVUS CSN. Restenosis appeared to be determined primarily by the direction and magnitude of the change in EEM CSA. An increase in EEM CSA was adaptive while a decrease in EEM CSA contributed to restenosis. The most powerful predictor of restenosis was the IVUS post-procedural CSN. The importance of the post-procedural CSN was related to the change in EEM CSA as a mechanism of restenosis.
Treatment of Cryptococcal Meningitis in KwaZulu-Natal, South Africa (2010)

Even in a setting where amphotericin B is available, mortality from cryptococcal meningitis in this setting is high, particularly in the immediate period after diagnosis. This highlights the still unmet need not only for earlier diagnosis of HIV and timely access to treatment of opportunistic infections, but for better treatment strategies of cryptococcal meningitis.
Thermal and chemical vapor deposition of Si nanowires: Shape control, dispersion, and electrical properties (2007)

We investigate and compare complementary approaches to SiNW production in terms of yield, morphology control, and electrical properties. Vapor-phase techniques are considered, including chemical vapor deposition (with or without the assistance of a plasma) and thermal evaporation. We report Au-catalyzed nucleation of SiNWs at temperatures as low as 300°C using SiH4 as precursor. We get yields up to several milligrams by metal-free condensation of SiO powders. For all processes, we control the final nanostructure morphology. We then report concentrated and stable dispersions of SiNWs in solvents compatible with semiconducting organic polymers. Finally, we investigate the electrical response of intrinsic SiNWs grown by different methods. All our SiNWs exhibit p-type behavior and comparable performance, though in some cases ambipolar devices are observed. Thus, processing and morphology, rather than the growth technique, are key to achieve optimal samples for applications.
A study on poly(vinyl chloride) blends with chlorinated polyethylene and acrylic resin (1987)

Abstract The compatibility, morphology, fusion behavior, and mechanical properties of blends of poly(vinyl chloride) (PVC), acrylic resin (ACR), and chlorinated polyethylene (CPE) (100/0–30/0–20) were studied. The experimental results show that the compatibility of the polyblend increases with the amount of ACR added. The blends composed of PVC/ACR/CPE (100/3–25/10–15) are fairly compatible. So far as impact strength is concerned, partially compatible blends are preferred.
Soundings in Middle Australia (1980)

The review, analysis and comparison of 'Sometimes Gladness', the collected poems of Bruce Dawe and 'The Peasant Mandarin', the collected prose pieces of Les Murray, is discussed. Both Murray and Dawe, but particularly Murray, reveal in their writing an unusual erudition which, tempered by the casual colloquial element in their style, appear as the folk erudition of the yarner.
Copper damascene interconnects for the 65 nm technology node: a first look at the reliability properties (2003)

Copper interconnects with end-of-roadmap feature sizes, fabricated in damascene technology, were electrically and thermally stressed to assess reliability performance. The maximum current carrying capability of 63 nm wide copper wires was found to be a factor of 2 higher when compared with current technologies. The impact of the Cu seed layer thickness on activation energy and stress voiding is discussed. The first lifetime estimations, assuming the ITRS roadmap requirements, were also made.
Exogenous levodopa increases the neuro retinal dopamine of guinea pig myopic eyes in vitro. (2011)

Our results suggest that exogenous L-DOPA can cause an increase in retinal dopamine in form-deprived guinea pig eyes in vitro, and that müller cells are involved in the increase in retinal dopamine.
Glass Transition in Ultrathin Polymer Films: Calorimetric Study (2003)

The ultrasensitive differential scanning calorimetry is used to observe the glass transition in thin (1-400 nm) spin-cast films of polystyrene, poly (2-vinyl pyridine) and poly (methyl methacrylate) on a platinum surface. A pronounced glass transition is observed even at a thickness as small as 1-3 nm. Using the high heating (20-200 K/ms) and cooling (1-2 K/ms in glass transition region) rates which are typical for this technique, we do not observe appreciable dependence of the glass transition temperature over the thickness range from hundreds of nanometers down to 3 nm thick films. The evolution of calorimetric data with film thickness is discussed in terms of broadening of transition dynamics and loss of transition contrast.
Photocatalytic hydrogenation of propyne with water on small-particle titania: size quantization effects and reaction intermediates (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotocatalytic hydrogenation of propyne with water on small-particle titania: size quantization effects and reaction intermediatesMasakazu. Anpo, Takahito. Shima, Sukeya. Kodama, and Yutaka. KubokawaCite this: J. Phys. Chem. 1987, 91, 16, 4305–4310Publication Date (Print):July 1, 1987Publication History Published online1 May 2002Published inissue 1 July 1987https://doi.org/10.1021/j100300a021RIGHTS & PERMISSIONSArticle Views2491Altmetric-Citations649LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (771 KB) Get e-Alerts
Coexistence of a sulphate‐reducing <i>Desulfovibrio</i> species and the dehalorespiring <i>Desulfitobacterium frappieri</i> TCE1 in defined chemostat cultures grown with various combinations of sulphate and tetrachloroethene (2001)

A two-member co-culture consisting of the dehalorespiring Desulfitobacterium frappieri TCE1 and the sulphate-reducing Desulfovibrio sp. strain SULF1 was obtained via anaerobic enrichment from soil contaminated with tetrachloroethene (PCE). In this co-culture, PCE dechlorination to cis-dichloroethene was due to the activity of the dehalorespiring bacterium only. Chemostat experiments with lactate as the primary electron donor for both strains along with varying sulphate and PCE concentrations showed that the sulphate-reducing strain outnumbered the dehalogenating strain at relatively high ratios of sulphate/PCE. Stable co-cultures with both organisms present at similar cell densities were observed when both electron acceptors were supplied in the reservoir medium in nearly equimolar amounts. In the presence of low sulphate/PCE ratios, the Desulfitobacterium sp. became the numerically dominant strain within the chemostat co-culture. Surprisingly, in the absence of sulphate, strain SULF1 did not disappear completely from the co-culture despite the fact that there was no electron acceptor provided with the medium to be used by this sulphate reducer. Therefore, we propose a syntrophic association between the sulphate-reducing and the dehalorespiring bacteria via interspecies hydrogen transfer. The sulphate reducer was able to sustain growth in the chemostat co-culture by fermenting lactate and using the dehalogenating bacterium as a 'biological electron acceptor'. This is the first report describing growth of a sulphate-reducing bacterium in a defined two-member continuous culture by syntrophically coupling the electron and hydrogen transfer to a dehalorespiring bacterium.
The use of C1q, conglutinin and low affinity rabbit IgM antibody to human Fc in a ligand coctail radioassay for detecting and characterizing immune complexes in pathological sera. (1980)

A ligand radioassay for the detection of IC which utilizes C1q, bovine conglutinin and low affinity rabbit IgM anti-human Fc in a reagent coctail, is presented. IC are first isolated from serum by precipitation in polyethylene glycol, then analysed for their ability to react with the ligand coctail. Dual-label studies with 125I and 131I-tagged ligands, designed to determine whether the ligands bound independently to IC, indicate that the binding of each ligand to IC is not significantly affected by the presence of the other two ligands. The results of assaying pathological sera for IC by the ligand coctail radioassay correlate well with the results of three other assays. The assay system is also flexible enough to allow other low affinity IgM reagents to be used which could potentially cover the whole range of immunoglobulin classes occurring in pathological IC.
A Reconfigurable SIW Cavity-Backed Slot Antenna With One Octave Tuning Range (2013)

A reconfigurable Substrate Integrated Waveguide Cavity-Backed Slot (SIW-CBS) antenna is presented with one octave tuning range and six different tuning states using a new tuning method. The method is based on loading the SIW cavity with shortening posts and manipulating the field distribution within the cavity. This tuning method shifts up the operating frequency of the antenna. Based on the number of the posts and their location, this frequency shift can be controlled. Benefiting from a two-layer structure and therefore being totally isolated from the biasing circuit, the CBS antenna can be easily tuned by switching the posts using p-i-n diodes. Using this technique a frequency tuning ratio <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$(f_{TR}=f_{up}/f_{low})$</tex> </formula> as high as an octave (1.1–2.2 GHz) is achieved. The impedance and radiation characteristics of the CBS antenna are presented and discussed. The antenna shows similar radiation patterns with low cross-polarization levels and high front to back ratio for all six states. To the authors' knowledge this is the first presentation of a SIW-CBS tunable antenna with one octave tuning and also the technique used for antenna tuning.
Identification of Anti-prion Compounds using a Novel Cellular Assay (2016)

Prion diseases are devastating neurodegenerative disorders with no known cure. One strategy for developing therapies for these diseases is to identify compounds that block conversion of the cellular form of the prion protein (PrP<sup>C</sup>) into the infectious isoform (PrP<sup>Sc</sup>). Most previous efforts to discover such molecules by high-throughput screening methods have utilized, as a read-out, a single kind of cellular assay system: neuroblastoma cells that are persistently infected with scrapie prions. Here, we describe the use of an alternative cellular assay based on suppressing the spontaneous cytotoxicity of a mutant form of PrP (Δ105-125). Using this assay, we screened 75,000 compounds, and identified a group of phenethyl piperidines (exemplified by LD7), which reduces the accumulation of PrP<sup>Sc</sup> in infected neuroblastoma cells by >90% at low micromolar doses, and inhibits PrP<sup>Sc</sup>-induced synaptotoxicity in hippocampal neurons. By analyzing the structure-activity relationships of 35 chemical derivatives, we defined the pharmacophore of LD7, and identified a more potent derivative. Active compounds do not alter total or cell-surface levels of PrP<sup>C</sup>, and do not bind to recombinant PrP in surface plasmon resonance experiments, although at high concentrations they inhibit PrP<sup>Sc</sup>-seeded conversion of recombinant PrP to a misfolded state in an in vitro reaction (RT-QuIC). This class of small molecules may provide valuable therapeutic leads, as well as chemical biological tools to identify cellular pathways underlying PrP<sup>Sc</sup> metabolism and PrP<sup>C</sup> function.
A virtual bus for dynamic parallel processing (2002)

The paper proposes an efficient interconnection network architecture called virtual bus that can sustain nonuniform traffic by dynamically allowing time sharing of network bandwidth among processing nodes. The bandwidth sharing is controlled by a fast variable priority arbitration scheme with a round-robin scheduling policy. The virtual bus architecture allows efficient implementation; with current technology, the virtual bus can achieve giga packets and tera bits per second throughputs in less than 5% of the total cost of an eight thousand port system.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Formation of low resistance and transparent ohmic contacts to <i>p</i>-type GaN using Ni–Mg solid solution (2003)

We report on the formation of Ni–Mg solid solution/Au ohmic contacts on p-GaN (5×1017 cm−3). The as-deposited Ni–Mg solid solution (8 nm)/Au (8 nm) contact shows near-linear I–V characteristics. However, oxidizing the contacts at 450 and 550 °C for 1 min in air results in a dramatic improvement in their I–V behaviors, producing specific contact resistance of ∼10−6 Ω cm2, which is much better than the conventional oxidized Ni/Au contacts. The light transmittance of the Ni–Mg solid solution/Au contacts annealed at 550 °C is measured to be better than 79% at a wavelength of 460 nm. Based on the I–V measurements, Auger electron spectroscopy, and x-ray photoemission spectroscopy results, possible ohmic formation mechanisms are described.
Progress and Status of a 2G HTS Power Cable to Be Installed in the Long Island Power Authority (LIPA) Grid (2010)

Underground high temperature Superconductor (HTS) power cables have attracted extensive interest in recent years due to their potential for high power density. With funding support from the United States Department of Energy (DOE), the world's first transmission voltage level HTS power cable has been designed, fabricated and permanently installed in Long Island Power Authority (LIPA) grid. The HTS cable was successfully commissioned on April 22, 2008. In 2007, a new DOE Superconductor Power Equipment (SPE) program to address the outstanding issues for integrating HTS cables into the utility grid was awarded to the current project team (LIPA II). The goal of the LIPA II is to develop and install a replacement phase conductor manufactured using AMSC's second generation wire. In addition to the replacement of the phase conductor, the team will also address the outstanding components development necessary for full scale integration into a power grid including integral management of thermal shrinkage of the cable conductor, optimization of the cryostat design to mitigate the implications of potential cable damage, and the development and demonstration of a field splice in the operating utility grid and modular higher efficiency refrigeration system. This paper will report on the progress and status of LIPA II program. In addition, in-grid operation experience of existing 1G HTS Power cable is presented.