gebhart/patrepeval huggingface dataset:
Simple Total Syntheses of Biologically Active Pentathiadecane Natural Products, 2,4,5,7,9-Pentathiadecane 2,2,9,9-Tetraoxide (Dysoxysulfone), from Dysoxylum richii, and 2,3,5,7,9-Pentathiadecane 9,9-Dioxide, the Misidentified Lenthionine Precursor SE-3 from Shiitake Mushroom (Lentinus edodes) (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSimple Total Syntheses of Biologically Active Pentathiadecane Natural Products, 2,4,5,7,9-Pentathiadecane 2,2,9,9-Tetraoxide (Dysoxysulfone), from Dysoxylum richii, and 2,3,5,7,9-Pentathiadecane 9,9-Dioxide, the Misidentified Lenthionine Precursor SE-3 from Shiitake Mushroom (Lentinus edodes)Eric Block, Russell DeOrazio, and Mohan ThiruvazhiCite this: J. Org. Chem. 1994, 59, 9, 2273–2275Publication Date (Print):May 1, 1994Publication History Published online1 May 2002Published inissue 1 May 1994https://pubs.acs.org/doi/10.1021/jo00088a001https://doi.org/10.1021/jo00088a001research-articleACS PublicationsRequest reuse permissionsArticle Views556Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Busulfan Produces Efficient Human Cell Engraftment in NOD/LtSz-<i>Scid IL2Rγ</i> <i>Null</i> Mice (2008)

Xenografting immunodeficient mice after low-dose irradiation has been used as a surrogate human hematopoietic stem cell (HSC) assay; however, irradiation requires strict and meticulous animal support and can produce significant mortality rates, limiting the usefulness of this model. In this work, we examined the use of parenteral busulfan as an alternative conditioning agent. Busulfan led to dose-dependent human HSC engraftment in NOD/LtSz-scid/IL2Rgamma(null) mice, with marked improvement in survival rates. Terminally differentiated B and T lymphocytes made up most of the human CD45+ cells observed during the initial 5 weeks post-transplant when unselected cord blood (CB) products were infused, suggesting derivation from existing mature elements rather than HSCs. Beyond 5 weeks, CD34+-enriched products produced and sustained superior engraftment rates compared with unselected grafts (CB CD34+, 65.8% +/- 5.35%, vs. whole CB, 4.27% +/- 0.67%, at 24 weeks). CB CD34+ group achieved significantly higher levels of engraftment than mobilized CD34+-enriched peripheral blood (PB CD34+). At 8 weeks, all leukocyte subsets were detected, yet human red blood cells (RBCs) were not observed. Transfused human red cells persisted in the chimeric mice for up to 3 days; an accompanying rise in total bilirubin suggested hemolysis as a contributing factor to their clearance. Recipient mouse-derived human HSCs had the capacity to form erythroid colonies in vitro at various time points post-transplant in the presence of human transferrin (Tf). When human Tf was administered singly or in combination with anti-CD122 antibody and human cytokines, up to 0.1% human RBCs were detectable in the peripheral blood. This long evasive model should prove valuable for the study of human erythroid cells.
Information behavior of scholarly community with e-resources: A case study of Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir (2015)

The study of faculty members and PhD scholars of Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir (SKUAST-K) was conducted to bring about current image about some core issues related to use of both online and offline e-resources. Attempt has also been made to ascertain some significant facts about their search strategy/skills and level of satisfaction. The constituent faculties of the University under study were surveyed through a structured questionnaire distributed among 90 subjects in proportion with their number. The study reveals that majority of the faculty members and PhD scholars of SKUAST-Kashmir are familiar about e-resources like CDROM databases, e-journals, e-books, etc. Scholars preferably use Laptops and mobiles as compared to Desktops for browsing their needed information. As expected, it is divulged that scholars prefer Google search engine mostly for browsing their desired information and ‘keyword’ or ‘subject’ searching techniques are applied by them to retrieve precise information. The respondents seem to be less skilled to use the advanced search techniques as a good number of respondents claimed that they have never used Boolean Gates (AND, OR, NOT); Wild Cards (*; #; $; etc); Truncation marks (??; #; *; etc) and the Phrasal Search "----". It calls for speedy implementation of Information literacy programs within the campus. Moreover, the study also reveal that scientists and the PhD scholars of SKUAST-Kashmir are not much satisfied with staff assistance; infrastructure; condition of computers and also face problems like internet connectivity and accessibility of e-resources, which is never encouraging.
Methionine Sulfoxides on Prion Protein Helix-3 Switch on the α-Fold Destabilization Required for Conversion (2009)

Our results suggest that the sulfoxidation of Helix-3 methionines might be the switch for triggering the initial alpha-fold destabilization required for the productive pathogenic conversion.
<sup>60</sup>Co‐γ radiation induces differential acetylation and phosphorylation of histones H3 and H4 in wheat (2011)

Histone modifications occur during DNA damage and repair in eukaryotes. These modifications were analysed in wheat seedlings exposed to (60) Co-γ radiation. Seedling height was not significantly affected in the first 2 days after irradiation up to 150 Gy. Subsequently, in the next 2 weeks, there was 30-40% reduction in seedling height, indicating that there were late effects of irradiation. The histones isolated from irradiated seedlings were analysed in the initial stages for modifications of H3 and H4 using antibodies. Global acetylation of H3 decreased and H4 increased in a dose-dependent manner till 100 Gy. The time course of individual modifications showed that for H3K4 and H3K9, acetylation decreased, whereas for H3S10 phosphorylation increased. There were fluctuations in acetylation of H4K5, H4K12 and H4K16, whereas H4K8 showed hyper-acetylation. The results indicate that γ radiation induced DNA damage and repair in wheat seedlings and initiated differential acetylation of H3 and H4. This is the first report in plants on site-specific H3 and H4 modifications in response to exposure to ionizing radiation.
S0-Mode Lithium Niobate Acoustic Delay Lines with 1 dB Insertion Loss (2018)

This paper demonstrates low-loss acoustic delay lines based on the fundamental symmetrical (S0)mode in lithium niobate thin films for the first time. The demonstrated devices harness the high electromechanical coupling, low loss, and fast phase velocity of the symmetrical mode in the X-cut lithium niobate to achieve an insertion loss as low as 1 dB at 300 MHz. The designs adopt single-phase unidirectional transducers to achieve low insertion loss and flat group delay responses simultaneously. Devices with different key parameters are implemented with fractional bandwidths ranging from 4.1% to 12.8% and delays ranging from 32 ns to 195 ns. With the demonstrated low loss and wide bandwidths, these devices can unlock new possibilites for low-power RF signal processing in the acoustic domain.
Nonlethal Bird Repellents: In Search of a General Model Relating Repellency and Chemical Structure (1991)

Larry Clark, Pankaj S. Shah, Nonlethal Bird Repellents: In Search of a General Model Relating Repellency and Chemical Structure, The Journal of Wildlife Management, Vol. 55, No. 3 (Jul., 1991), pp. 538-545
Differentiation-Dependent Phosphorylation of a 175,000 Molecular Weight Protein in Response to Insulin and Insulin-Like Growth Factor-I in L6 Skeletal Muscle Cells* (1989)

Insulin and insulin-like growth factor-I (IGF-I) effects on protein phosphorylation were investigated in intact skeletal muscle cells at different stages of differentiation. In undifferentiated L6 myoblasts, stimulation by either insulin or IGF-I, but not IGF-II, led to a 3- to 5-fold increase in phosphorylation of insulin and IGF receptor beta-subunits and the appearance of a 175,000 mol wt (Mr) phosphoprotein (pp175). These effects reached a maximum within 3 min, were maintained for 12 min, and then declined. Dose-response curves for pp175 phosphorylation in response to insulin (ED50 = 2 nM) and IGF-I (ED50 = 0.2 nM) were consistent with occupancy and stimulation of each receptor kinase by its specific hormone. The 175,000 Mr phosphoprotein was not precipitated by antireceptor antibodies, and the phosphoamino acid composition differed markedly from that of insulin and IGF-I receptors, with a 10-fold lower phosphotyrosine/phosphoserine ratio after insulin stimulation. In contrast to insulin and IGF-I receptors, pp175 was not extracted by the nonionic detergent Triton X-100, but required sodium dodecyl sulfate for solubilization. When experiments were carried out with L6 cells after differentiation into skeletal muscle myotubes, hormone-induced phosphorylation of pp175 was almost undetectable. We conclude that pp175 is a phosphoprotein distinct from insulin and IGF-I receptors that is involved in the early phosphorylation events that follow the activation of the insulin and IGF-I receptor kinases. Its disappearance after terminal differentiation of the L6 cells is consistent with a role in hormonal stimulation of cell proliferation.
Study of the near ultraviolet emission of tellurium-doped xenon flashlamps (1979)

High-current Xe-filled flashlamps were doped with Te in an attempt to enhance the near ultraviolet emission in the spectral region 250 to 290 nm. The addition of Te resulted in flashlamp performance similar to that of an undoped flashlamp in the high pressure limit.
In Vivo Brain Magnetic Resonance Spectroscopy: A Measurement of Biomarker Sensitivity to Post-Processing Algorithms (2014)

Clinical translation of reported biomarkers requires reliable and consistent algorithms to derive biomarkers. However, the literature reports statistically significant differences between 1-D MRS measurements from control groups and subjects with disease states but frequently provides little information on the algorithms and parameters used to process the data. The sensitivity of in vivo brain magnetic resonance spectroscopy biomarkers is investigated with respect to parameter values for two key stages of post-acquisitional processing. Our effort is specifically motivated by the lack of consensus on approaches and parameter values for the two critical operations, water resonance removal, and baseline correction. The different stages of data processing also introduce varying levels of uncertainty and arbitrary selection of parameter values can significantly underutilize the intrinsic differences between two classes of signals. The sensitivity of biomarkers points to the need for a better understanding of how all stages of post-acquisitional processing affect biomarker discovery and ultimately, clinical translation. Our results also highlight the possibility of optimizing biomarker discovery by the careful selection of parameters that best reveal class differences. Using previously reported data and biomarkers, our results demonstrate that small changes in parameter values affect the statistical significance and corresponding effect size of biomarkers. Consequently, it is possible to increase the strength of biomarkers by selecting optimal parameter values in different spectral intervals. Our analyses with a previously reported data set demonstrate an increase in effect sizes for wavelet-based biomarkers of up to 36%, with increases in classification performance of up to 12%.
Linear phase retrieval for wave-front sensing (1998)

Phase retrieval from one or more intensity measurements is a potentially powerful and appealing technique for real-time adaptive-optics wave-front sensors. Under the assumption of small wave-front phase excursions, one is able to derive an exact solution to the inverse problem given three or more intensity measurements with known phase offsets. Applications include a high-order wave-front sensor to correct for residual aberrations in an adaptive-optics system in tandem with a low-resolution Hartmann-Shack wave-front sensor. The formula can also furnish mathematical insights into the full nonlinear phase-retrieval task.
Photoelectrochemical etching of n-type 4H silicon carbide (2004)

Photoelectrochemical etching of highly doped n-type 4H SiC in dilute hydrofluoric acid along different crystallographic orientations under low voltage and/or low current conditions is studied. Scanning electron microscope images show that anodization of the hexagonal polytype 4H SiC with subsequent pore formation proceeds anisotropically. It is proposed that under uv illumination the crystallographic planes terminated with silicon atoms are more resistant to electrolytic attack than the planes terminated with carbon and mixed silicon-carbon atoms. This model is used to explain the observed triangular-channel pore morphologies. A clear indication was found that the resultant pore structure does not depend on the direction of the external electric field applied to the sample. Electrical parameters recorded as part of the photoelectrochemical etching process are described and interpreted.
Structured Sequence Modeling with Graph Convolutional Recurrent Networks (2016)

This paper introduces Graph Convolutional Recurrent Network (GCRN), a deep learning model able to predict structured sequences of data. Precisely, GCRN is a generalization of classical recurrent neural networks (RNN) to data structured by an arbitrary graph. Such structured sequences can represent series of frames in videos, spatio-temporal measurements on a network of sensors, or random walks on a vocabulary graph for natural language modeling. The proposed model combines convolutional neural networks (CNN) on graphs to identify spatial structures and RNN to find dynamic patterns. We study two possible architectures of GCRN, and apply the models to two practical problems: predicting moving MNIST data, and modeling natural language with the Penn Treebank dataset. Experiments show that exploiting simultaneously graph spatial and dynamic information about data can improve both precision and learning speed.
Replacement of dietary fish oil with increasing levels of linseed oil: Modification of flesh fatty acid compositions in Atlantic salmon (<i>Salmo salar</i>) using a fish oil finishing diet (2004)

Five groups of salmon, of initial mean weight 127 +/- 3 g, were fed increasing levels of dietary linseed oil (LO) in a regression design. The control diet contained capelin oil (FO) only, and the same oil was blended with LO to provide the experimental diets. After an initial period of 40 wk, all groups were switched to a finishing diet containing only FO for a further 24 wk. Growth and flesh lipid contents were not affected by dietary treatment. The FA compositions of flesh total lipids were linearly correlated with dietary FA compositions (r2 = 0.88-1.00, P < 0.0001). LO included at 50% of added dietary lipids reduced flesh DHA and EPA (20:5n-3) concentrations to 65 and 58%, respectively, of the concentrations in fish fed FO. Feeding 100% LO reduced flesh DHA and EPA concentrations to 38 and 30%, respectively, of the values in fish fed FO. Differences between diet and flesh FA concentrations showed that 16:0, 18:1n-9, and especially DHA were preferentially retained in flesh, whereas 18:2n-6, 18:3n-3, and 22:1n-11 were selected against and presumably utilized for energy. In fish previously fed 50 and 100% LO, feeding a finishing diet containing FO for 16 wk restored flesh DHA and EPA concentrations, to approximately 80% of the values in fish fed FO throughout. Flesh DHA and EPA concentrations in fish fed up to 50% LO were above recommended intake values for humans for these EFA. This study suggests that LO can be used as a substitute for FO in seawater salmon feeds and that any reductions in DHA and EPA can be largely overcome with a finishing diet high in FO before harvest.
Organic-Inorganic Hybrid Material for Electro-Optic Modulator (2001)

Abstract Organic-inorganic hybrid material (SIAZO-VP2) for nonlinear optics was prepared by the sol-gel processable monomer derived from 3-isocyanatopropyltriethoxysilane with hydroxy-functionalized nonlinear optical cliromophores. The measured value of NLO coefficient strongly depended on conditions such as poling temperature, poling time and heating rate. The maximum value of SIAZO-VP2 film which was heated at 200°C exhibited d33 = 64 pm/V in Maker-fringe measurement It was found that the thermal stability of the film was greatly enhanced as poling time increased and a poling temperature became higher. Using this hybrid material, we fabricated a vertically asymmetric coupled electro-optic modulator. The resulting device exhibited a good performance with the extinction ratio of ca. 9 dB, the half wave voltage of 5 V, and the bandwidth of 1.5 MHz at the wavelength of 633 nm.
Valproic acid in childhood epilepsy: anticonvulsive efficacy in relation to its plasma levels. (1980)

Plasma levels of valproic acid were monitored for two years in 90 epileptic children. From 34 patients receiving sodium valproate as monotherapy, complete seizure control could be achieved in 28 children (82%) with a mean (+/- SD) plasma level of 65.1 +/- 20.3 micrograms/ml. In 6 patients (18%) seizures recurred. Since their plasma levels were significantly (p = 0.008) higher (91.7 +/- 35.2 micrograms/ml) than in the controlled patients, their disorder might be regraded as resistant to therapy with sodium valproate. The drug seems to be effective in patients with absences, tonic-clonic seizures and partial epilepsy. The most common combination of anticonvulsants administered was valproate/phenobarbital (n = 22). In 14 children of this group (64%) seizures were completely controlled with plasma levels of 54.6 +/- 26.5 micrograms/ml. In the 5 uncontrolled patients (23%) valproate concentrations were lower (33.8 +/- 28.2 micrograms/ml; p = 0.08). 20 children were treated with more than two anticonvulsants. This population probably represents the most severe cases. Therefore it was not surprising that only 7 patients (35%) exhibited complete seizure control with valproate plasma concentrations of 63.1 +/- 51.9 micrograms/ml. In the uncontrolled patients these levels were slightly lower (43.8 +/- 24.8 micrograms/ml). Side effects were observed in 7 patients (21%) receiving sodium valproate alone. Most common effects were increase in appetite (n = 4), and gastrointestinal disturbances (n = 2). Additionally, one patient complained about transient hair loss and one felt tired. In most cases their plasma concentrations were above 70 micrograms/ml. A therapeutic range of 40--90 micrograms/ml is postulated.
Parkinson’s Disease Drug Therapies in the Clinical Trial Pipeline: 2020 (2020)

There is a broad pipeline of both symptomatic and disease modifying therapies currently being tested in clinical trials for PD.
A Debugging System for Sensor Networks (2005)

Being embedded in the physical world, sensor networks present a wide range of bugs and misbehavior qualitatively different than those in most distributed systems. Unfortunately, due to resource constraints, programmers must investigate these bugs with only limited visibility into application behavior. We need a new approach. This paper presents the design and evaluation of Sympathy, a tool for detecting and debugging failures in pre- and post-deployment sensor networks. Sympathy consists of mechanisms for reporting generic system and application metrics; mechanisms for identifying conditions based on these metrics; a simple debugging algorithm to detect failures based on the conditions; and a system for logging metrics and events in their spatiotemporal context. We describe Sympathy and evaluate its performance through fault injection, and by debugging an active application, ESS, in simulation, emulation, and deployment. We show that Sympathy"s analysis and choice of metrics help programmers detect failures and correlate events into the root causes of bugs.
LETTUCE MOSAIC (1939)

S ummary Previous records of lettuce mosaic are cited. The symptoms of the disease on lettuce are described, and the variation in the reaction of different varieties of cabbage lettuce indicated. The host range is extended to certain composite weeds (including groundsel, Senecio vulgaris ) and to members of the family Leguminosae (Pisum sativum. Laihyrus odoratus). Experiments in which the virus was seed transmitted through lettuce to the extent of about 6 % are described, and the results of experiments with aphis vectors reported. An account of field observations on the influence of the weather on the disease is given. Certain properties of the virus are described and the status of the virus is discussed. Control measures are suggested.
Multiple Decision Aided Successive Interference Cancellation Receiver for NOMA Systems (2017)

Non-orthogonal multiple access (NOMA) is one of the critical technologies in fifth generation systems. Successive interference cancellation (SIC) is a typical solution of multiple users detection in NOMA systems. However, conventional SIC suffers from error propagation. To alleviate this problem, in this letter, a multiple decision SIC (MD-SIC) strategy is introduced. Instead of choosing one codeword for each user in traditional SIC detection, the proposed algorithm introduces multiple codewords as the candidates to combat the error propagation. Furthermore, a threshold is designed to control the size of candidate set for each user. It helps the MD-SIC to achieve a better tradeoff between performance and complexity. The simulation results indicate that the MD-SIC algorithm obviously outperforms the conventional SIC with a little additional computational complexity.
Effects of topically instilled drugs on intraocular pressure in rabbits. (1975)

The effect of the ocular instillation of some drugs on the intraocular pressure of non-anaesthetized rabbits was studied, using the Schiötz tonometer. The risk of systemic absorption of drugs follwoing ocular instillation was evaluated by 1. measuring the spreading of effects from the treated eye to the contralateral one and 2. studying the effects on blood pressure or on blood pressure responses to noradrenaline. The results showed that trazodone, epinephrine and acetazolamide produced hypotension on the treated eye; there was no spreading of effects to the contralateral one. These data could suggest that the primary site of action of these drugs is the eye. Naphazoline reduced the intraocular pressure both on the treated eye and, with a constant delay, on the contralateral one. This was interpreted as a combination of a local action and systemic absorption. The effects of chlorpromazien were more complex. This drug produced hypertension and a strong irritation on the treated eye as well as a hypotensive effect on the contralateral one. The rise in intraocular pressure was probably caused by irritation; the hypotensive effect by systemic absorption. The following drugs were inactive: amphetamine, chlorothiazide and pilocarpine.