gebhart/patrepeval huggingface dataset:
<i>In vivo</i> non‐invasive monitoring of collagen remodelling by two‐photon microscopy after micro‐ablative fractional laser resurfacing (2013)

Non-linear optical microscopy is becoming popular as a non-invasive in vivo imaging modality in dermatology. In this study, combined TPF and SHG microscopy were used to monitor collagen remodelling in vivo after micro-ablative fractional laser resurfacing. Papillary dermis of living subjects, covering a wide age range, was imaged immediately before and forty days after treatment. A qualitative visual examination of acquired images demonstrated an age-dependent remodelling effect on collagen. Additional quantitative analysis of new collagen production was performed by means of two image analysis methods. A higher increase in SHG to TPF ratio, corresponding to a stronger treatment effectiveness, was found in older subjects, whereas the effect was found to be negligible in young, and minimal in middle age subjects. Analysis of collagen images also showed a dependence of the treatment effectiveness with age but with controversial results. While the diagnostic potential of in vivo multiphoton microscopy has already been demonstrated for skin cancer and other skin diseases, here we first successfully explore its potential use for a non-invasive follow-up of a laser-based treatment.
Inversion of stereoselectivity in a metallocene catalyst (1996)

Abstract Inversion of stereoselectivity of a particular metallocene (Me 2 Si(Flu) (N‐ t ‐Bu)ZrCl 2 ) (Me: methyl, Flu: fluorenyl, t ‐Bu: tert ‐butyl) from syndiospecific into isospecific was observed by changing the cocatalyst from methylaluminoxane (MAO) to [Ph 3 C] + [B(C 6 F 5 ) 4 ] − /AliBu 3 (iBu:isobutyl). The change of the solvent‐separated ion pair (in case of MAO as cocatalyst) into the contact ion pair (in case of the more polar and less bulky borate anion) was proposed as the plausible explanation of this phenomenon.
A new correlation for saturated densities of liquids and their mixtures (1979)

Abstract A new correlation has been developed for the densities of saturated liquids and their mixtures. The correlation is relatively easy to use and is applicable to a wide variety of liquids. The saturated liquid density correlation is flexible and consistent and requires only reduced temperature, acentric factor, and a characteristic volume for each pure compound. Mixing rules are given. When tested against a data base of 2 657 points of pure compound liquid density data for 97 hydrocarbons and 1 851 points for 103 other compounds, the new correlation gave an average absolute error of 0.37% compared to 2.14% for the Yen‐Woods correlation and 0.50% for the SDR equation as modified by Spencer and Danner. For 2 994 points of liquid mixture density data for 167 mixtures, the new correlation gave an average absolute error of 1.40% compared to 5.64% for the Yen‐Woods correlation and 2.95% for the SDR equation. Characteristic volumes are listed for 200 compounds; they are generalized as functions of acentric factor for various types of compounds and are compared to critical volumes.
Effect of bio‐based monomers on the scratch resistance of acrylate photopolymerizable coatings (2014)

ABSTRACT Photopolymerizable clear coatings based on bio‐sourced acrylates, dedicated to the protection of polycarbonate substrates, were studied. The bio‐sourced compounds were not based on triglycerides but were smaller, industrially available molecules similar to classical petro‐based monomers. Their polymerization kinetics was studied by photo‐DSC and was shown to allow high acrylate conversions even at 25 °C. Closely related coatings enriched in alkyl segments, or in monoacrylates to decrease the crosslinking density, were compared. The material composition affects its nanomorphology deduced from X‐ray diffraction. Although these changes in composition can slightly shift the mechanical relaxation, it remains wide, and the elastic modulus remains high (>10 8 Pa) for all the tested materials. Microscratch experiments highlighted the efficiency of all the new coatings in terms of protection against scratches. Incorporating a monoacrylate, particularly isobornyl acrylate, can improve the scratch resistance especially in terms of critical load (up to 175% increase compared with a classical petro‐based coating). © 2014 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2015 , 53 , 379–388
New hybrid tetrachalcogenofulvalenes: diselenaditellurafulvalene and its dimethyl derivative (1997)

K. Takimiya and A. Morikami, Chem. Commun., 1997, 1925 DOI: 10.1039/A704974I
Dose‐Dependent Effects of Betaxolol in Hypertension: A Double‐Blind, Multicenter Study (1992)

This study determined the dose-response relationship among three doses of betaxolol compared with placebo in patients with mild-to-moderate hypertension. In this double-blind, placebo-controlled trial, 317 hypertensive patients were randomly assigned to receive placebo or betaxolol 5, 10, or 20 mg once daily for 4 weeks. A significant (P less than .05) decrease in supine diastolic blood pressure (BP) compared with concurrent placebo was evident with all three doses of betaxolol after 1 week of active treatment. Each dose of betaxolol maintained a significant reduction in diastolic and systolic BP and heart rate responses throughout the 4-week treatment period. At the fourth week (final treatment evaluation), BP and heart rate were significantly (P less than .05) reduced by all three doses of betaxolol compared with placebo. For supine systolic and diastolic BP, the decreases with betaxolol 20 mg were significantly (P less than .05) greater than with the 5 mg dose, but there was no statistically significant difference between the 10-mg and either the 5- or 20-mg doses. For standing diastolic BP, the effect of betaxolol 5 mg once daily was significantly (P less than .05) less than that of 10 and 20 mg. The overall supine diastolic BP response to betaxolol was dose dependent, and more patients responded to the 10- and 20-mg doses of betaxolol (66% and 76%, respectively) than to the 5-mg dose (59%). For each efficacy variable, the absolute magnitude of the reduction was greater with increasing dose. In subgroup analyses, BP responses were analyzed by race, age, baseline BP, and age combined with baseline BP.(ABSTRACT TRUNCATED AT 250 WORDS)
Paspalum staggers: isolation and identification of tremorgenic metabolites from sclerotia of Claviceps paspali (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPaspalum staggers: isolation and identification of tremorgenic metabolites from sclerotia of Claviceps paspaliRichard J. Cole, Joe W. Dorner, John A. Lansden, Richard H. Cox, Countney Pape, Barry Cunfer, Stephen S. Nicholson, and David M. BedellCite this: J. Agric. Food Chem. 1977, 25, 5, 1197–1201Publication Date (Print):May 1, 1977Publication History Published online1 May 2002Published inissue 1 May 1977https://pubs.acs.org/doi/10.1021/jf60213a061https://doi.org/10.1021/jf60213a061research-articleACS PublicationsRequest reuse permissionsArticle Views459Altmetric-Citations99LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Protein-tyrosine Phosphatase (PTP) Wedge Domain Peptides (2006)

Inhibition of protein-tyrosine phosphatases (PTPs) counterbalancing protein-tyrosine kinases (PTKs) offers a strategy for augmenting PTK actions. Conservation of PTP catalytic sites limits development of specific PTP inhibitors. A number of receptor PTPs, including the leukocyte common antigen-related (LAR) receptor and PTPmu, contain a wedge-shaped helix-loop-helix located near the first catalytic domain. Helix-loop-helix domains in other proteins demonstrate homophilic binding and inhibit function; therefore, we tested the hypothesis that LAR wedge domain peptides would exhibit homophilic binding, bind to LAR, and inhibit LAR function. Fluorescent beads coated with LAR or PTPmu wedge peptides demonstrated PTP-specific homophilic binding, and LAR wedge peptide-coated beads precipitated LAR protein. Administration of LAR wedge Tat peptide to PC12 cells resulted in increased proliferation, decreased cell death, increased neurite outgrowth, and augmented Trk PTK-mediated responses to nerve growth factor (NGF), a phenotype matching that found in PC12 cells with reduced LAR levels. PTPmu wedge Tat peptide had no effect on PC12 cells but blocked the PTPmu-dependent phenotype of neurite outgrowth of retinal ganglion neurons on a PTPmu substrate, whereas LAR wedge peptide had no effect. The survival- and neurite-promoting effect of the LAR wedge peptide was blocked by the Trk inhibitor K252a, and reciprocal co-immunoprecipitation demonstrated LAR/TrkA association. The addition of LAR wedge peptide inhibited LAR co-immunoprecipitation with TrkA, augmented NGF-induced activation of TrkA, ERK, and AKT, and in the absence of exogenous NGF, induced activation of TrkA, ERK, and AKT. PTP wedge domain peptides provide a unique PTP inhibition strategy and offer a novel approach for augmenting PTK function.
Standards for Competence in Braille Literacy Skills in Teacher Preparation Programs (2002)

This article reports on a descriptive study of standards and criteria for competence in braille literacy within teacher preparation programs and the specific role played in the achievement of proficiency in braille literacy by university teacher preparation programs in blindness and visual impairment. It contains a summary of the need for such research, historical background, research methods, and a discussion of standards and implications for personnel preparation.
Histological response to injected gluteraldehyde cross-linked bovine collagen based implant in a rat model (2006)

Abstract Background The aim of present study is to investigate the short and long term histopathological alterations caused by submucosal injection of gluteraldehyde cross-linked bovine collagen based on an experimental rat model. Methods Sixty Sprague-Dawley rats were assigned into two groups as group I and II each containing 30 rats. 0.1 ml of saline solution and 0.1 ml of gluteraldehyde cross-linked bovine collagen were injected into the submucosa of bladder of first (control) and second groups, respectively. Both group I and II were further subdivided into 3 other groups as Group IA, IB, IC and Group IIA, IIB, IIC according to the sacrification period. Group IA and IIA, IB and IIB, IC and IIC rats (10 rats for each group) were sacrificed 3, 6, and 12 months after surgical procedure, respectively. Two slides prepared from injection site of the bladder were evaluated completely for each rat by being unaware of the groups and at random by two independent senior pathologists to determine the fibroblast invasion, collagen formation, capillary ingrowth and inflammatory reaction. Additionally, randomized brain sections from each rat were also examined to detect migration of the injection material. The measurements were made using an ocular micrometer at ×10 magnification. The results were assessed using t-tests for paired and independent samples, with p < 0.05 considered to indicate significant differences; all values were presented as the mean (SD). Results Migration to the brain was not detected in any group. Significant histopathological changes in the gluteraldehyde cross-linked bovine collagen injected groups were fibroblast invasion in 93.3%, collagen formation in 73.3%, capillary ingrowth in 46.6%, inflamatory reaction in 20%. Conclusion We emphasize that the usage of gluteraldehyde cross-linked bovine collagen in children appears to be safe for endoscopic treatment of vesicoureteral reflux.
Functional capabilities of lower limb amputees (1984)

Five hundred lower limb amputees were evaluated by personal interview at the Artificial Limb Centre, Pune, India. Information thus obtained on activities of daily living and functional capabilities with their prostheses was analysed. The analysis showed that 55% of the amputees were totally independent, 40% had to use a crutch or cane and only 5% were solely dependent on a wheelchair for ambulation. Further, it was also confirmed that as age increased, functional independence decreased, and that below-knee amputees were more independent than above-knee and bilateral amputees. When compared with reports of other workers from the developed countries, the results were equally good, and in some functions, were even better.
The CLARAty architecture for robotic autonomy (2002)

This paper presents an overview of a newly developed Coupled Layer Architecture for Robotic Autonomy (CLARAty), which is designed for improving the modularity of system software while more tightly coupling the interaction of autonomy and controls. First, we frame the problem by briefly reviewing previous work in the field and describing the impediments and constraints that been encountered. Then we describe why a fresh approach to the topic is warranted, and introduce our new two-tiered design as an evolutionary modification of the conventional three-level robotics architecture. The new design features a tight coupling of the planner and executive in one Decision Layer, which interacts with a separate Functional Layer at all levels of system granularity. The Functional Layer is an object-oriented software hierarchy that provides basic capabilities of system operation, resource prediction, state estimation, and status reporting. The Decision Layer utilizes these capabilities of the Functional Layer to achieve goals by expanding, ordering, initiating and terminating activities. Both declarative and procedural planning methods are used in this process. Current efforts are targeted at implementing an initial version of this architecture on our research Mars rover platforms, Rocky 7 and 8. In addition, we are working with the NASA robotics and autonomy communities to expand the scope and participation in this architecture, moving toward a flight implementation in the 2007 time-frame.
High-speed transport components (1991)

An overview of research of high-speed transport components is given. High-speed protocols as well as high-speed implementations are considered. The use of parallelism to increase the performance of communication nodes is considered. A parallel implementation of Open Systems Interconnection (OSI) protocols on transputer networks based on the parallel concepts discussed is described. Selected performance values of the implementations are presented. The outlook on the design of high-speed transport components for future communication systems is examined.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Investigation of Reducing Bow during High Aspect Ratio Trench Etching in 3D NAND Flash Memory (2018)

One challenge of high aspect ratio etching in 3D NAND flash memory is to maintain the perpendicularity of the etching profile. In this paper, a method is proposed to reduce bow during high aspect ratio trench etching. Bottom critical dimension/top critical dimension (BT) ratio and bow critical dimension (CD) are two pivotal parameters. This work focuses on the etching of SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> /SiN <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> trench with aspect ratio larger than 50:1. By studying multiple influencing factors especially the function of different gas matching in every step, bow CD is improved while maintaining BT ratio in expectation.
Cicatricial alopecia; a dermatopathologic and immunopathologic study of 33 patients (pseudopelade of brocq is not a specific clinico‐pathologic entity) (2002)

In conclusion, PB is a type of scarring alopecia of the scalp associated with a peculiar clinical presentation and evolution, which cannot be considered an autonomous nosologic entity because in 66.6% of patients it is the end stage of other inflammatory chronic diseases such as LPP and DLE. It is conceivable that even in those cases in which the histopathological and immunopathological findings did not allow for a specific diagnosis, LPP and DLE were also involved. It is noteworthy that in our study the histopathological and the immunopathological examinations did not conflict and often the results were even coincidental, thus confirming the compatibility of the combined histo-immunopathological approach in the diagnostic evaluation of PB.
Cytomegalovirus infection of human retinal tissue: an in vivo model. (1994)

This model allows HCMV to actively infect and replicate within highly differentiated human neural tissue. It produces pathology characteristic of CMV-infected neural tissue in a time course suitable for long-term study. The nature of this model will allow the study of: the replication properties of HCMV in nervous tissue, the specific effects of HCMV on the human retina, the interaction of HCMV with other viruses, e.g., HIV, and various anti-viral therapies.
Metformin Inhibits Cell Proliferation, Migration and Invasion by Attenuating CSC Function Mediated by Deregulating miRNAs in Pancreatic Cancer Cells (2011)

Pancreatic cancer is the fourth leading cause of cancer-related deaths in the United States, which is, in part, due to intrinsic (de novo) and extrinsic (acquired) resistance to conventional therapeutics, suggesting that innovative treatment strategies are required for overcoming therapeutic resistance to improve overall survival of patients. Oral administration of metformin in patients with diabetes mellitus has been reported to be associated with reduced risk of pancreatic cancer and that metformin has been reported to kill cancer stem cells (CSC); however, the exact molecular mechanism(s) has not been fully elucidated. In the current study, we examined the effect of metformin on cell proliferation, cell migration and invasion, and self-renewal capacity of CSCs and further assessed the expression of CSC marker genes and microRNAs (miRNA) in human pancreatic cancer cells. We found that metformin significantly decreased cell survival, clonogenicity, wound-healing capacity, sphere-forming capacity (pancreatospheres), and increased disintegration of pancreatospheres in both gemcitabine-sensitive and gemcitabine-resistant pancreatic cancer cells. Metformin also decreased the expression of CSC markers,CD44, EpCAM,EZH2, Notch-1, Nanog and Oct4, and caused reexpression of miRNAs (let-7a,let-7b, miR-26a, miR-101, miR-200b, and miR-200c) that are typically lost in pancreatic cancer and especially in pancreatospheres. We also found that reexpression of miR-26a by transfection led to decreased expression of EZH2 and EpCAM in pancreatic cancer cells. These results clearly suggest that the biologic effects of metformin are mediated through reexpression of miRNAs and decreased expression of CSC-specific genes, suggesting that metformin could be useful for overcoming therapeutic resistance of pancreatic cancer cells.
The products of the kdpDE operon are required for expression of the Kdp ATPase of Escherichia coli (1992)

The expression of the Kdp system for K+ uptake in Escherichia coli requires the products of two genes, kdpD and kdpE. These genes constitute an operon adjacent to the kdpABC operon that encodes the three membrane protein subunits of Kdp. Both operons are transcribed in the same direction and overlap; the kdpDE promoter is in kdpC, the last gene of the kdpABC operon. Transcription of the kdpDE operon is at a low level when Kdp is not expressed; transcription increases about 10-fold when kdpABC is turned on, indicating significant read-through of the kdpDE operon by transcripts beginning at the promoter of kdpABC operon. The proximal region of the kdpD gene is the site of most mutations that lead to constitutive expression of the kdpABC operon.
Dressed optical filaments (2012)

In this Letter we show that by appropriately providing an auxiliary "dress" beam one can extend the longevity of an optical filament by almost one order of magnitude. These optical dressed filaments can propagate substantially further by judiciously harnessing energy from their secondary beam reservoir. This possibility is theoretically investigated in air when the filament is dressed with a conically convergent annular Gaussian beam.
Design of diffractive-phase axicon illuminated by a Gaussian-profile beam (1996)

The diffractive-phase axicon can convert the Gaussian-profile beam into axial uniform intensity distribution with long focal depth and high lateral resolution. Two types of phase-retardation functions for the nonuniform-illuminating axicon are derived in terms of the ray tracing and the geometrical law of energy conservation. Based on the general theory of the amplitude-phase retrieval in optical system and the iteration algorithm, the optimization design of the phase distribution of the diffractive-phase axicon can be achieved. The simulation calculations show that the new approach may successfully offer the design of the desired diffractive-phase axicon with long focal depth and high lateral resolution. A comparison of the performances of the holographic axicon with the phase-retardation functions from the geometrical optics prediction and the diffractive-phase axicon designed by the new approach is also presented.
Support of Homeostatic Glial Cell Signaling: A Novel Therapeutic Approach by Propentofylline<sup>a</sup> (1997)

A pathological glial cell activation, which forces microglia to transform into immunocompetent cells with cytotoxic properties and astrocytes to "de-differentiate," presumably adds to neurodegenerative diseases. We examined the modulatory effect of adenosine on the Ca2+ and cAMP-dependent regulation of such reactive glial cell properties in culture and tested possibilities of pharmacologic reinforcement. A strengthening of the cAMP-signaling, as could be achieved by adenosine agonists via a Ca(2+)-dependent action, favored the differentiation of proliferating astrocytes and associated neuroprotective properties (ion homeostasis, formation of trophic factors). But potentially neurotoxic properties of microglial cells were inhibited. Adenosine depressed their proliferation rate and transformation into macrophages, their particularly high formation of reactive oxygen intermediates and the release of the cytokine TNF-alpha. Similar effects were obtained with propentofylline, which acts as selective cAMP/cGMP phosphodiesterase inhibitor and also increases the effective concentration of adenosine by blocking its cellular reuptake. The recently observed induction of microglial apoptosis by elevated extracellular adenosine levels may further contribute to limit secondary nerve cell damage related to a pathological glial cell activation.