gebhart/patrepeval huggingface dataset:
Computation with the help of a digital computer of magnetic anomalies caused by bodies of arbitrary shape (1965)

Abstract Formulas are derived for the magnetic anomalies caused by irregular polygonal laminas. These are used to obtain the three components of the magnetic anomalies caused by a finite homogeneously magnetized body of arbitrary shape. There is no restriction to the direction of magnetization; in general, it may not be the same as that of the earth's field. Total-intensity anomalies are also obtained. Use of these formulas in a computer program is discussed and illustrated by computing the anomaly caused by Caryn Seamount. Simplified formulas are presented for the anomalies caused by finite rectangular laminas. In addition to bodies of complex shape, the computer program can also be profitably used for computing the magnetic anomalies caused by bodies of relatively simple geometry. The second derivatives of the gravitational potential of a massive body, that is, quantities familiarly known as gradient and curvature in torsion-balance work and the first vertical derivative in gravity work are also obtained by this method.
Survivable Traffic Grooming in Elastic Optical Networks—Shared Protection (2012)

This study investigates the survivable traffic grooming problem for elastic optical networks with flexible spectrum grid employing new transmission technologies. In such networks, instead of following the traditional fixed ITU-T wavelength grid, optical transponders are capable of properly tuning their rates, and consequently their spectrum occupation, by introducing the fine-granular spectrum unit, called a frequency slot. The number of contiguous frequency slots allocated to an optical path (i.e., lightpath) is adjusted to the current network flow. In this study, we propose a novel shared protection specific to elastic networks, namely, elastic separate-protection-at-connection (ESPAC). It not only provides traditional backup sharing, but also offers a new opportunity of spectrum sharing enabled by the elasticity of the transponders: 1) if the working paths of two connections are link disjoint physically, and 2) if their backup paths traverse two lightpaths which are adjacent on a fiber link, then the two backup lightpaths can share spectrum. The new opportunity of spectrum sharing is realized by using First-Fit to assign working traffic and Last-Fit to assign backup traffic, and allowing spectrum overlap between adjacent backup wavelengths. The elasticity of the transponder enables the expansion and contraction of the lightpaths, thus when a single failure occurs in the network, lightpaths carrying backup flows can be tuned to appropriate rates in such a way that the overlap spectrum is used by only one of the adjacent lightpaths. The results show ESPAC is very spectrum efficient in elastic network setting.
Collection devices influence the constituents of exhaled breath condensate: Fig. 1— (2007)

To the Editors:
Antibodies to native myelin oligodendrocyte glycoprotein are serologic markers of early inflammation in multiple sclerosis (2006)

Myelin oligodendrocyte glycoprotein (MOG) is an integral membrane protein expressed in CNS oligodendrocytes and outermost myelin lamellae. Anti-MOG Abs cause myelin destruction (demyelination) in animal models of multiple sclerosis (MS); however, such pathogenic Abs have not yet been characterized in humans. Here, a method that specifically detects IgG binding to human MOG in its native, membrane-embedded conformation on MOG-transfected mammalian cells was used to evaluate the significance of these auto Abs. Compared with healthy controls, native MOG-specific IgGs were most frequently found in serum of clinically isolated syndromes ( P < 0.001) and relapsing-remitting MS ( P < 0.01), only marginally in secondary progressive MS ( P < 0.05), and not at all in primary progressive MS. We demonstrate that epitopes exposed in this cell-based assay are different from those exposed on the refolded, extracellular domain of human recombinant MOG tested by solid-phase ELISA. In marmoset monkeys induced to develop MS-like CNS inflammatory demyelination, IgG reactivity against the native membrane-bound MOG is always detected before clinical onset of disease ( P < 0.0001), unlike that against other myelin constituents. We conclude that ( i ) epitopes displayed on native, glycosylated MOG expressed in vivo are early targets for pathogenic Abs; ( ii ) these Abs, which are not detected in solid-phase assays, might be the ones to play a pathogenic role in early MS with predominant inflammatory activity; and ( iii ) the cell-based assay provides a practical serologic marker for early detection of CNS autoimmune demyelination including its preclinical stage at least in the primate MS model.
alpha-Lipoic acid treatment decreases serum lactate and pyruvate concentrations and improves glucose effectiveness in lean and obese patients with type 2 diabetes. (1999)

Treatment of lean and obese diabetic patients with LA prevents hyperglycemia-induced increments of serum lactate and pyruvate levels and increases SG.
Cell-Specific Expression of the <i>ZPK</i> Gene in Adult Mouse Tissues (1996)

ZPK is a recently identified human putative protein kinase gene that encodes an unusual serine/threonine kinase containing two potential leucine zipper motifs similar to those found in transcription factors as well as in members of the newly discovered mixed-lineage family of protein kinases. To study the normal biological function of ZPK, we have isolated a mouse ZPK cDNA and examined the pattern of ZPK mRNA expression in adult mouse tissues by Northern blot and in situ hybridization analyses. The predicted open reading frame of this cDNA encodes an 888-amino-acid protein that shares 95% overall identity with its human counterpart. By Northern blot analysis, we detected expression of ZPK mRNA in the brain of adult mice, but not in any other tissue tested. In situ hybridization analysis of mouse brain sections revealed specific association of ZPK mRNA with neuronal cell populations, primarily in the hippocampus, the cerebral cortex, and the Purkinje cell layer of the cerebellum. Interestingly, a remarkable pattern of cell-type-specific expression was also found in the epithelial compartment of various organ systems, including stomach, small intestine, liver, and pancreas, as well as in the seminiferous tubules of mature testes. Taken together, these observations suggest that ZPK could play a role in development, function, and maintenance of a variety of specialized cells.
Downhole flow controllers in mitigating challenges of long reach horizontal wells: A practical outlook with case studies (2017)

Production and injection in long reach horizontal wells pose several challenges in production optimization, flow assurance and reservoir management. Horizontal wells are known to be superior to vertical wells in terms of productivity, however, they are also susceptible to early water and/or gas cut production due to the heel-toe effect and/or permeability contrasts. Uniform distribution of water injection into all zones can also be a challenge in case of high-permeability streaks and fractures. To negate some of the adverse reservoir properties and to control the flow profile of production and injection fluids, downhole flow control devices are increasingly in use and beneficial in regulating flow, improved overall reservoir sweep, improved productivity from the tail section of the well and reduced water coning or gas cusping. Wellbore hydraulics for a long reach well completed with downhole valves have great influence on the reservoir performance and recovery in the long run. This paper presents a discussion aimed at better understanding of the critical challenges that long reach horizontal wells are prone to in terms of completion, as well as the developments so-far that have been applied to capture the physics across the long horizontal section. Three case studies are also discussed with some details emphasizing practical experiences of such wells.   Key words: Downhole flow controllers, horizontal wells, inflow control devices (ICD), internal control valves (ICV), production enhancement.
Synthesis of 3-cyclopentenols by alkoxy-accelerated vinylcyclopropane rearrangement (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of 3-cyclopentenols by alkoxy-accelerated vinylcyclopropane rearrangementRick L. Danheiser, Carlos Martinez-Davila, and John M. Morin Jr.Cite this: J. Org. Chem. 1980, 45, 7, 1340–1341Publication Date (Print):March 1, 1980Publication History Published online1 May 2002Published inissue 1 March 1980https://doi.org/10.1021/jo01295a045Request reuse permissionsArticle Views878Altmetric-Citations57LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (305 KB) Get e-Alertsclose Get e-Alerts
A high-performance full-motion video compression chip set (1992)

A seven-chip set which performs the functions associated with video and image compression algorithms, and CCITT H.261 in particular, has been designed, fabricated, and is fully functional. The major functions performed by the devices include motion estimation, DCT and IDCT, forward and inverse quantization, Huffman coding and decoding, BCH error correction, and loop filtering. The chips that perform the predictive and transform coding section of the algorithm operate with pixel rates up to 40 MHz. Array-based technologies of 1.5 and 1.0 mu m CMOS were used extensively to achieve a 28 man-month design time. Each die is less than 10 mm on a side.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Quantum Speed Limit for Physical Processes (2013)

The evaluation of the minimal evolution time between two distinguishable states of a system is important for assessing the maximal speed of quantum computers and communication channels. Lower bounds for this minimal time have been proposed for unitary dynamics. Here we show that it is possible to extend this concept to nonunitary processes, using an attainable lower bound that is connected to the quantum Fisher information for time estimation. This result is used to delimit the minimal evolution time for typical noisy channels.
Pharmacokinetics and systemic effects of tissue-type plasminogen activator in normal subjects (1989)

Pharmacokinetics and systemic effects of recombinant tissue-type plasminogen activator (rt-PA) were studied in 18 healthy male volunteers after 30-minute intravenous infusions of placebo, 0.25 mg/kg rt-PA, and 0.5 mg/kg rt-PA. Highly comparable pharmacokinetic parameters were obtained after analysis of rt-PA as both an antigen and an activity. Mean clearance (antigen) was 620 +/- 70 (SD) ml/min, volume of distribution at steady state was 8.1 +/- 0.8 L, initial volume of distribution was 4.4 +/- 0.6 L, and dominant half-life was 4.4 +/- 0.3 minutes. The pharmacokinetics of rt-PA were linear, showed low interindividual variation, and are compatible with rapid hepatic elimination of the protein. Systemic plasminogen activation was minimal as assessed by hemostatic assays of plasma samples treated with anti-rt-PA Immunoglobulin G (IgG) to inhibit in vitro fibrinogenolysis. Circulating fibrinogen levels, clotting times, and coagulation factors were unchanged; plasminogen and alpha 2-antiplasmin decreased maximally to 85% and 65% of baseline values, respectively. The data are consistent with the fibrin specificity of t-PA, which is derived from its role in physiologic fibrinolysis.
A novel instruction scratchpad memory optimization method based on concomitance metric (2006)

Scratchpad memory has been introduced as a replacement for cache memory as it improves the performance of certain embedded systems. Additionally, it has also been demonstrated that scratchpad memory can significantly reduce the energy consumption of the memory hierarchy of embedded systems. This is significant, as the memory hierarchy consumes a substantial proportion of the total energy of an embedded system. This paper deals with optimization of the instruction memory scratchpad based on a novel methodology that uses a metric which we call the concomitance. This metric is used to find basic blocks which are executed frequently and in close proximity in time. Once such blocks are found, they are copied into the scratchpad memory at appropriate times; this is achieved using a special instruction inserted into the code at appropriate places. For a set of benchmarks taken from Mediabench, our scratchpad system consumed just 59% (avg) of the energy of the cache system, and 73% (avg) of the energy of the state of the art scratchpad system, while improving the overall performance. Compared to the state of the art method, the number of instructions copied into the scratchpad memory from the main memory is reduced by 88%.
CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase C-gamma(1) upon B cell activation. (1996)

Cross-linking B cell antigen receptor (BCR) elicits early signal transduction events, including activation of protein tyrosine kinases, phosphorylation of receptor components, activation of phospholipase C-gamma (PLC-gamma), and increases in intracellular free Ca2+. In this article, we report that cross-linking the BCR led to a rapid translocation of cytosolic protein tyrosine phosphatase (PTP) 1C to the particulate fraction, where it became associated with a 140-150-kD tyrosyl-phosphorylated protein. Western blotting analysis identified this 140-150-kD protein to be CD22. The association of PTP-1C with CD22 was mediated by the NH2-terminal Src homology 2 (SH2) domain of PTP-1C. Complexes of either CD22/PTP-1C/Syk/PLC-gamma(1) could be isolated from B cells stimulated by BCR engagement or a mixture of hydrogen peroxidase and sodium orthovanadate, respectively. The binding of PLC-gamma(1) and Syk to tyrosyl-phosphorylated CD22 was mediated by the NH2-terminal SH2 domain of PLC-gamma(1) and the COOH-terminal SH2 domain of Syk, respectively. These observations suggest that tyrosyl-phosphorylated CD22 may downmodulate the activity of this complex by dephosphorylation of CD22, Syk, and/or PLC-gamma(1). Transient expression of CD22 and a null mutant of PTP-1C (PTP-1CM) in COS cells resulted in an increase in tyrosyl phosphorylation of CD22 and its interaction with PTP-1CM. By contrast, CD22 was not tyrosyl phosphorylated or associated with PTP-1CM in the presence of wild-type PTP-1C. These results suggest that tyrosyl-phosphorylated CD22 may be a substrate for PTP-1C regulates tyrosyl phosphorylation of CD22.
The Inhibition of Adenosine Kinase by α,ω-Di (Adenosin -<u>N</u><sup>6</sup>- YL) Alkanes<sup>1</sup> (1989)

Abstract Members of a series of α,ω-di(adenosin- N 6-yl)alkanes, comprising two adenosine residues linked with alkyl bridges from 1 to 14 methylene units in length, were found to be inhibitors of rat liver and BHK cell adenosine kinase. The inhibition was competitive with respect to adenosine and non-competitive with respect to ATP. The corresponding α,ω-di(cytidin-N 4-yl) alkanes were not inhibitors and N 6-alkyladenosines inhibited only weakly.
A Competitive Enzyme-Linked Immunosorbent Assay for Measuring the Levels of Serum Antibody to<i>Haemophilus influenzae</i>Type b (1998)

A competitive ELISA method is described for the measurement of total antibodies to the capsular polysaccharide of Haemophilus influenzae type b (HibCPS) in human sera. The competitive method showed an excellent correlation to the radioantigen binding assay (RABA, or Farr assay) and improved correlation of sera with low titers with respect to the more conventional noncompetitive method. Overestimation of samples in the low concentration range was no longer observed with the competitive ELISA method. The free HibCPS competition allowed us to eliminate the day-to-day background variation typical of some sera; thus, only values representing the true anti-HibCPS response were determined. The use of precoated microplates, which could be stored up to 8 months, greatly improved the speed of the procedure. An overall correlation coefficient of 0. 9660 was found when 407 serum samples with a wide variety of anti-HibCPS antibody levels were tested with the competitive ELISA and RABA. The regression line was very close to the ideal line, with a slope of 1.0045 and an intercept of -0.1996. A subset of 96 serum samples representative of all pre- and postimmunization samples was used to compare the competitive ELISA with a previously described ELISA method. The competitive method performed in two laboratories in different countries showed a better correlation with the RABA. The correlation factors were 0.9770 and 0.9816, respectively, while a factor of 0.9547 was found with the previously described noncompetitive procedure, which was better for this method than previously reported (r = 0.917). Therefore, the competitive ELISA is proposed for the assay of anti-HibCPS titers in sera from vaccinated subjects.
Simulating mixed analog-digital circuits on a digital simulator (2003)

Time-domain simulation of circuits which contain analog functional blocks such as gain stages, filters and analog-digital conversion modules can be concurrently simulated with digital components on an event-driven digital simulator. A technique for modeling such analog circuits using digital behavior models has been developed. The simulation of mixed analog-digital circuits based on this methodology has been implemented on an accelerated digital simulator. An automated gain control circuit is presented as an example.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Experimental Investigation Of On-Line Methods For Incipient Fault Detection (2000)

Condition-based maintenance (CBM) of industrial equipment is generally recognized as being the most cost-effective means for improving equipment availability. However, prerequisite to successful implementation of CBM is a reliable detector of failing components. One such detector, termed the effective negative-sequence impedance, had previously been identified as an indicator of induction motor stator winding degradation. However, a limitation of this detector is that it does not change in a predicable manner under certain motor operating conditions. This paper presents an experimental investigation of an improved technique for on-line detection of induction motor stator winding degradation. The paper begins with a brief description of the detectors, followed by a detailed description of the experimental setup, the experiments conducted, and results.
Human kidney "enkephalinase", a neutral metalloendopeptidase that cleaves active peptides (1983)

After extracting converting enzyme from a membrane fraction of homogenized human kidney, "enkephalinase" activity was solubilized with Triton X-100. Ion-exchange chromatography resolved two peaks of the "enkephalinase" activity, both of which cleaved Leu5-enkephalin at the Gly3-Phe4 bond. The major "enkephalinase" form was purified 1140-fold to homogeneity with a 14% yield. This homogeneous "enkephalinase" had a specific activity of 46 mumol min-1 mg-1 with Leu5-enkephalin as substrate. The purified enzyme, in addition to hydrolyzing Leu5-enkephalin, cleaved synthetic substrates with protected N- and C-terminal ends. On the basis of the specificity of the enzyme and its inhibition by chelating agents, human "enkephalinase" can be classified as a neutral metalloendopeptidase with a broad substrate specificity. The activity of this neutral endopeptidase with several biologically active peptides was compared to that of homogeneous human kidney converting enzyme. Both enzymes inactivated bradykinin by release of the C-terminal dipeptide but were inhibited differentially by specific inhibitors. Comparison of hydrolysis of bradykinin with that of its protected C-terminal peptide indicated that the neutral endopeptidase is more active toward the larger substrate than is converting enzyme. Although the neutral endopeptidase did not convert angiotensin I to II, it did hydrolyze angiotensin I at Pro7-Phe8 and inactivate angiotensin II by cleavage at the Tyr4-Ile5 bond.
Stochastic models of manufacturing systems (1993)

1. Discrete Part Manufacturing Systems. 2. Evolution of Manufacturing System Models: An Example. 3. Single Stage 'Produce-to-Order' Systems. 4. Single Stage 'Produce-to-Stock' Systems. 5. Flow Lines. 6. Transfer Lines. 7. Dynamic Job Shops. 8. Flexible Machining Systems. 9. Flexible Assembly Systems. 10. Multiple Cell Manufacturing Systems. 11. Unresolved Issues: Directions for Future Research. Appendix A: Standard Probability Distributions. Appendix B: Some Notions of Stochastic Ordering. Appendix C: Nonparametric Families of Distributions.
Searching for multiple targets with measurement dependent noise (2015)

We consider a search problem in which multiple targets are uniformly placed on the unit interval. An agent, who might not know the number of targets in advance, is interested in acquiring all targets to within some resolution δ as quickly as possible. To that end, at each time unit, the agent can probe any region of the unit interval for the presence of targets but the associated measurement noise increases with the size of the probed region. We characterize the maximal targeting rate, the optimal tradeoff between resolution and expected search time, with adaptive and non-adaptive search strategies, highlighting the advantage of adaptive strategies. We show that even when the number of targets is known, in contrast to the case of constant measurement noise, there is a multiplicative gap between the performance of adaptive and non-adaptive search. This gap, however, diminishes as the number of targets grow.
Preparation and Property of the Water Absorbent Hybrid Resin (2001)

Water absorption material has been attracted much more attention for its wide use in soil and water conservation, agriculture, etc. But this material will actually apply in agriculture, soil and water conservation only when it is cheap enough. Pulp fiber and starch to prepare high absorbing-water resin is a good method for decreasing the cost [1,2]. However, it still has a long way to turn it into reality. Now the montmorillonite is widely used in preparing nanocomposites [3]. But used it in preparing absorbing-water resin has little report. In this article the water absorption hybrid resin has been prepared by one step intercalation polymerization method. In the process of intercalation the partly neutralization acrylic acid and urea have been used as intercalating reagent. Beside that, the urea also has been used as cross-linking agent.