gebhart/patrepeval huggingface dataset:
Successful Target Attainment of Telavancin at Elevated MICs: Fact or Fiction? (2012)

Lodise et al. aimed to characterize the pharmacokinetics andpharmacodynamics of telavancin among patients with complicated skin and skin structure infections (cSSSIs) and various degrees of renal function (6). During evaluation, an area under the concentration-time curve (AUC)/MIC ratio of 219 or more was selected as the pharmacodynamic target. The authors concluded that all proposed dosing regimens would achieve a 93 % or higher coverage in the population when the MIC is equal to 2 mg/liter (6). First, Lodise et al. referenced the target AUC/MIC ratio of 219 or more as the exposure target associated with a 1-log-unit de-crease in colony count from the baseline for methicillin-resistant Staphylococcus aureus (MRSA) (6). Inmultiple publications, there is evidence of significant variability between strains for the mag-nitude of the pharmacokinetic/pharmacodynamic (PK/PD) index needed to achieve the same pharmacodynamic endpoint (5, 8). As
Cisternal puncture complications. Treatment of coccidioidal meningitis with amphotericin B. (1973)

Of two patients who had acute neurologic damage from cisternal punctures, one died 17 hours following a tap which produced major subarachnoid hemorrhage, the other patient recovered from probable brain stem infarction associated with cisterna magna amphotericin injection. Subarachnoid hemorrhage is the commonest major complication of cisternal puncture, with at least 30 reported fatalities. Other serious complications result from direct puncture of brain substance.Cisternal puncture is not an appropriate alternative to a difficult lumbar puncture, and indications for its use are limited. The occasional required cisternal tap should be performed only by persons carefully trained in the technique, preferably utilizing fluoroscopic guidance, and only where neurosurgical assistance is readily available.Post-puncture subarachnoid hemorrhage accompanied by progressive obtundation requires emergency evaluation and consideration of posterior fossa decompression.
A parallel algorithm for allocation of spare cells on memory chips (1991)

The authors propose a parallel algorithm based on the artificial neural network model for solving the spare-allocation problem. The goal is to find a spare allocation which repairs all the faulty cells in the given faulty-cell map. The parallel algorithm requires 2n processing elements for the n*n faulty-cell map problem. The algorithm is verified by many simulation runs. Under the simulation the algorithm finds one of the near-optimum solutions in a nearly constant time with O(n) processors. The simulation results show the consistency of this algorithm. The algorithm can be easily extended for solving rectangular or other shapes of fault map problems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
An advanced integrated architecture for wireless voicemail data retrieval (2002)

This paper describes an alternative architecture for voicemail data retrieval on the move. It is comprised of three distinct components: a speech recognizer, a text summarizer and a WAP push service initiator, enabling mobile users to receive text summaries of their voicemail in real-time without an explicit request. Our approach overcomes the cost and usability limitations of the conventional voicemail retrieval paradigm which requires a connection establishment in order to listen to spoken messages. We report performance results on all different components of the system that has been trained and tested on a database containing 1843 North American English messages as well as on the duration of the corresponding data path. The proposed architecture can be further customized to meet the requirements of a complex voicemail value-added service.
A 3.4Gbps transmitter for multi-serial data communication using pre-emphasis method (2010)

Linear triads with ruthenium photosensitizers are frequently based on the Ru(terpyridine)(2)(2+) unit. We report on vectorial photoinduced electron transfer in a linear triad based on the Ru(bipyridine)(3)(2+) photosensitizer. Electron-hole separation over a 22 Å-distance is established with a quantum yield greater than 64% and persists for 1.3 μs in acetonitrile.
Descriptive and Inferential Statistics for Supervising and Monitoring the Operation of PV Plants (2009)

This paper deals with the problem of supervising and monitoring a photovoltaic (PV) plant. First, an offline descriptive and inferential statistical procedure for evaluating the goodness of system performance is presented. Then, an online inferential algorithm for real-time monitoring and fault detection is introduced. The two methodologies utilize the energy output of inverters as input data and are valid for both Gaussian and non-normal distribution of data. The procedures have been tested on a real PV installation, and results are reported for the case of a grid-connected PV plant in Italy for which one PV module over 132 resulted in being badly connected.
Synthesis of Acetylated α-and β-L-Fucosyl Esters of Nucleoside 5′-Monophosphates by the Orthoester Route (1982)

Abstract Reaction of 3,4-di-O-acetyl-1, 2-O (ethyl orthoacetyl)-α-L-fucopyranose with UMP and dTMP in N, N-dimethyl formamide gave the corresponding nucleoside-5′-(2,3,4-tri-O-acetyl-L-fucopyranosyl phosphoric acids) as a mixture of the α-and β-anomers.
Photopolymerization and Transport Properties of Liquid Crystalline Triphenylenes (1997)

Abstract The synthesis of polymerizable triphenylene derivatives with acrylate groups is described. The thermal properties and the photoconductive properties of the discotic monomers as well as of the polymers is investigated. In the mesophase typically photoinduced hole conductivity with a charge carrier mobility exceeding a value of 10−4 cm2/Vs is observed with conventional time-of-flight (TOF) techniques. Different conditions for the photopolymerization of the acrylates in the mesophase are compared. The influence of the photoinitiators and the polymerization on the mesomorphic behavior and on the hole conductivity is described. Already the presence of small amounts of photoinitiator influences the packing within the mesophase. The polymerization further decreases the order and creates defects. This results in an at least one order of magnitude reduced charge carrier mobility at room temperature, compared to the monomer.
Strain-engineering for improved tunneling in reconfigurable silicon nanowire transistors (2016)

Mechanical stress has the potential to be an efficient performance booster for diverse emerging research devices based on tunneling phenomena, such as tunnel FETs, resonant tunnel FETs and reconfigurable FETs. The effect is highly dependent on the constellation between the stress source and the crystal orientation. Although stress engineering is well established for enhancement carrier mobility, it is rather unexplored for the control of tunneling. In this work stress profiles formed by four different sources are studied by device simulations of reconfigurable silicon nanowire transistor using two independently gated Schottky junctions. Self-limited oxidation of the intrinsic silicon nanowire is used as an example to describe the effects of mechanical stress on the multi-valley band structure applying the deformation potential theory and on the average effective tunneling mass. The transfer characteristics of strained n- and p-type transistors are analyzed with respect to the current ratio between electron and hole conduction which is important to implement reconfigurable CMOS circuits. It has been verified that mechanical stress formed by oxidation as well as stressed top layers are effective options to control the current injection through the Schottky junctions and thus to achieve symmetric operation of reconfigurable nanowire devices.
Chemistry of potentially prebiological natural products (1992)

A. Eschenmoser and E. Loewenthal, Chem. Soc. Rev., 1992, 21, 1 DOI: 10.1039/CS9922100001
High-dimensional analysis of the adenosine pathway in high-grade serous ovarian cancer (2021)

Our study revealed the clinical, immunological, subtype-specific impacts of eADO signaling in HGSC, unveiled the chemoprotective effect of CD39 and supports the evaluation of eADO-targeting agents in patients with ovarian cancer.
Functional prediction of B. subtilis genes from their regulatory sequences. (1997)

In bacterial cells, gene expression is regulated by multiple sigma factors, each of which has its promoter specificity, according to their conditions. Thus, if we can discriminate which sigma factor binds to the upstream region of a given coding sequence, we can predict in what condition it will be expressed. In this paper, we show this approach is feasible for the analysis of Bacillus subtilis genome. Based on our collection of known promoter sequences, we prepared 8 predictors to characterize known sigma factors using the hidden Markov model and their prediction accuracies were estimated with a cross-validation test. Furthermore, we predicted the sigma-dependencies for each of 1415 candidate genes in the genome. Our prediction results are experimentally testable and seem useful for the post-sequencing project.
An integrated CMOS high voltage supply for lab-on-a-chip systems (2008)

Electrophoresis is a mainstay of lab-on-a-chip (LOC) implementations of molecular biology procedures and is the basis of many medical diagnostics. High voltage (HV) power supplies are necessary in electrophoresis instruments and are a significant part of the overall system cost. This cost of instrumentation is a significant impediment to making LOC technologies more widely available. We believe one approach to overcoming this problem is to use microelectronic technology (complementary metal-oxide semiconductor, CMOS) to generate and control the HV. We present a CMOS-based chip (3 mm x 2.9 mm) that generates high voltages (hundreds of volts), switches HV outputs, and is powered by a 5 V input supply (total power of 28 mW) while being controlled using a standard computer serial interface. Microchip electrophoresis with laser induced fluorescence (LIF) detection is implemented using this HV CMOS chip. With the other advancements made in the LOC community (e.g. micro-fluidic and optical devices), these CMOS chips may ultimately enable 'true' LOC solutions where essentially all the microfluidics, photonics and electronics are on a single chip.
The Radiation Recovery Factor: Preservation by the Polge-Smith-Parkes Technique (1955)

Journal Article The Radiation Recovery Factor: Preservation by the Polge-Smith-Parkes Technique Get access David W. H. Barnes, David W. H. Barnes Medical Research Council's Radiobiological Research Unit, Atomic Energy Research Establishment, Harwell, Berks, England Search for other works by this author on: Oxford Academic PubMed Google Scholar John F. Loutit John F. Loutit Medical Research Council's Radiobiological Research Unit, Atomic Energy Research Establishment, Harwell, Berks, England Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 15, Issue 4, February 1955, Pages 901–905, https://doi.org/10.1093/jnci/15.4.901 Published: 01 February 1955 Article history Received: 11 October 1954 Published: 01 February 1955
Fish oil stabilisation by microencapsulation with modified cellulose (2004)

Fish oil is the richest dietary source of long-chain omega-3 polyunsaturated fatty acids (PUFA). Stabilisation of omega-3 PUFA against oxidation is an important task in food processing. The ability of modified celluloses to act as microencapsulating agents for fish oil was investigated. Fish oil microcapsules were produced by spray-drying of homogenised emulsions containing modified celluloses and maltodextrin as coating materials. The quality of microcapsules was evaluated by scanning electron microscopy, determination of encapsulation efficiency, peroxide value during storage and solubility in water. Methylocellulose (MC) and hydroxypropyl methylocellulose (HPMC) showed good emulsifying properties. Homogenisation of emulsions resulted in creation of high amount of stable foam. More damage occurred in the powders coated with HPMC. The oil retention level was very high, 98.5% (i.e. up to 400.0 g/kg ready powder). Samples with fish oil content of approximately 500.0 g/kg exhibited more structural damage impairing the stabilisation effect. This study indicates that the use of modified cellulose, especially MC, as a coating material for the preparation of spray-dried fish oil microcapsules improves the stability and the concentration of fish oil in the powder.
Three-Point Hitch Dynamometer Design and Calibration (1987)

A three-point hitch dynamometer was designed, constructed and calibrated. The dynamometer is suitable for use with tractors up to 90 kW using category II and III mounted implements, and also trailed implements. A hydraulic clamp was used to absorb shock loads while equipment was being transported and lifted. Calibration of the dynamometer shows that the instrument is accurate to within 5% for draft forces ranging from 5 kN to 45 kN in any direction.
Association of Plasma γ′ Fibrinogen With Incident Cardiovascular Disease (2015)

These findings do not lend support to the hypothesis that γ' fibrinogen influences CVD events through its prothrombotic properties. Rather, γ' fibrinogen concentrations seem to reflect general inflammation that accompanies and may contribute to atherosclerotic CVD, instead of γ' fibrinogen being a causal risk factor.
ESSENTIALS OF PERSONAL RAPID TRANSIT (1997)

This article discusses the essentials of Personal Rapid Transit: Economic Derivation of the Basic Features of PRT (Small Cross-Section Guideways; Automation; Very Small Vehicles; Cost Per Unit of Capacity; Off-Line Stations; Operating and Maintenance Cost per Place-Mile; Maximum Daily Average Load Factor; On-Demand Services; Private-Party Service; Ratio of Daily Travel to Peak-Hour Travel; Reliable Control and Switching; Prior Art; Fractional-Second Headways; Vehicle Size and Configuration; Guideway Design); PRT Operations (Stations; Ticketing; Managing Destination Congestion; Entering the Vehicle; The Command to Line Speed; Merging Traffic; Route Management); and Planning Issues.
Flow rate dependence of in vitro removal of anti-A and anti-B antibodies by immunoadsorbents with synthetic oligosaccharides representing blood group substances. (1989)

In vitro removal of anti-A and anti-B antibodies by immunoadsorbents with synthetic oligosaccharide structures representing blood group substances have been studied under controlled and simulated extracorporeal perfusion conditions at different flow rates ranging from 20 to 160 mL/min. There is a gradual decline in antibody titers in the plasma, as it relates to the antibody binding capacity and efficiency of the immunoadsorbents, both as a function of time and plasma volume at any of the flow rates employed. Approximately the same maximal binding capacity is achieved in about 4 hours of perfusion regardless of the flow rate, whereas increased number of plasma volumes are required at higher flow rates to compensate for the appropriate residence times needed in the column to utilize the same capacity. The perfusion time alone appears to be a critical factor which via the flow rate determines the residence time between the plasma and the immobilized hapten in the column. Also, the optimal flow rate at which maximum binding capacity of the immunoadsorbent may be utilized efficiently appears to fall within a range of the flow rate. The factors determining this range and the efficiency of the immunoadsorbents under dynamic conditions are discussed. The results obtained under the controlled conditions and the discussions that follow are expected to be generally useful, at least, as approximate clinical guidelines, for selective removal of specific substances by extracorporeal perfusion techniques utilizing therapeutic intervention with immunoadsorbents in this important area of medical therapy.
<scp>GABA</scp>‐producing <i>Bifidobacterium dentium</i> modulates visceral sensitivity in the intestine (2016)

The functional significance of microbial-derived GABA was demonstrated by gadB-dependent desensitization of colonic afferents in a murine model of visceral hypersensitivity. Visceral pain modulation represents another potential health benefit attributed to bifidobacteria and other GABA-producing species of the intestinal microbiome. Targeting GABAergic signals along this microbiome-gut-brain axis represents a new approach for the treatment of abdominal pain.
Optimizing Portfolio Transitions (2001)

The goal of a transition manager is to balance opportunity costs with market impact costs, and implement portfolio restructurings at the lowest-possible transaction costs. If this objective is actually a type of dynamic optimization problem, what characteristics are embodied in an efficient and cost-effective transition manager?
Sound propagation in SiO2 aerogels (1992)

The longitudinal sound velocity vL of pure SiO2 aerogels with densities in the range of 5 to 500 kg m−3, either made from TEOS (tetraethoxysilane), TMOS (tetramethoxysilane), or waterglass was measured. The variation of vL with density ρ for evacuated aerogels is more complex than described earlier: The simple scaling law vL∝ρα, with α=1.3, only holds for ρ&gt;100 kg m−3; below this density α≊0.8 is valid. Data are also collected for sintered SiO2 aerogels. For specimens with densities around 100 kg m−3 or below, sound velocity measurements under variation of air pressure have also been performed. The dependence of the sound velocity on air pressure can be correctly described by a simple theory involving quasi-isothermal compression of the gas within the pores. From these findings a reliable method to determine the macroscopic aerogel density is derived.
A PRELIMINARY STUDY FOR IDENTIFYING NAT TRAFFIC USING MACHINE LEARNING (2014)

It is shown in the literature that the NAT devices have become a convenient way to hide the identity of malicious behaviors. In this thesis, the aim is to identify the presence of the NAT devices in the network traffic and (if possible) to predict the number of users behind those NAT devices. To this end, I utilize different approaches and evaluate the performance of these approaches under different network environments represented by the availability of different data fields. To achieve this, I propose a machine learning (ML) based approach to detect NAT devices. I evaluate my approach against different passive fingerprinting techniques representing the state-of-the-art in the literature and show that the performance of the proposed ML based approach is very promising even without using any payload (application layer) information.
The possibility of the plant on the air environment purification (2011)

植物は外界から大気汚染物質を体内へ取込み，代謝・分解して，大気浄化に貢献している．我々は大気汚染物質である二酸化窒素（NO2）に着目して，NO2浄化における植物の可能性について研究してきた．217種類の植物について，NO2代謝能を調査し，植物種間には最大657倍の差があることが分かった．遺伝子操作による研究から，NO2は，硝酸代謝経路を介して代謝浄化されるとの仮説が支持された．イオンビーム*1法により，高いNO2浄化能を持つオオイタビ新品種（KNOX）を作出した．KNOXは実用化されつつある．
Prolonged <i>In Vivo</i> Gene Expression Driven by a Tyrosine Hydroxylase Promoter in a Defective Herpes Simplex Virus Amplicon Vector (1996)

A 9.0-kb fragment of the tyrosine hydroxylase (TH) promoter, previously shown to direct tissue-specific expression in transgenic mice, was fused to an Escherichia coli LacZ reporter gene in a defective herpes simplex virus type-1 (HSV-1) amplicon vector (THlac). The HSV immediate early (IE) 4/5 promoter (HSVlac) was used as a control. LacZ gene expression was visualized by X-Gal histochemical and TH immunocytochemical analysis. Two days and 10 weeks after THlac injection into rat caudate nucleus (CN), X-Gal-stained cells were observed in the substantia nigra (SN) and locus ceruleus (LC) ipsilateral to the injection site. These blue cells were TH-positive neurons as evidenced by double labeling with immunocytochemistry. Moreover, the number of X-Gal+, TH+ (double-positive) neurons in the SN increased at 10 weeks as compared to that seen 2 days after THlac injection. In marked contrast, few double-positive nigral neurons were observed either 2 days or 10 weeks after direct injection of THlac into SN. However, neither nigral nor striatal injection of HSVlac resulted in prolonged gene expression. These results suggest that a neuronal, but not a viral, promoter in an HSV vector can produce cell-type-specific, prolonged, and stable gene expression following retrograde transport. In addition, THlac produced infrequent gene expression in TH-negative cells (CN and dorsal to SN) after THlac injection into CN and SN, respectively. Overall, these results suggest that in some in vivo contexts cell-type-preferred expression can be achieved by a cellular promoter in an amplicon vector. Moreover, they underscore the need for the careful and systematic study of neuronal promoters in HSV vectors.
An infrastructure for the development of Semantic Desktop applications (2009)

In einem permanent wachsenden Ausmaß wird unser Leben digital organisiert. Viele tagtägliche Aktivitäten manifestieren sich (auch) in digitaler Form: einerseits explizit, wenn digitale Informationen für Arbeitsaufgaben oder in der Freizeit entstehen und verwendet werden; andererseits auch implizit, wenn Informationen indirekt, als Konsequenz unseres Handelns, erzeugt oder manipuliert wird. Ein großer Teil dieser Informationsbestände ist persönlicher Natur, d.h., diese Information hat einen bestimmten Bezug zu uns als Person. Die Speicher- und Rechenleistung der Geräte, mit denen wir üblicherweise mit solchen persönlichen Daten interagieren, wurde in den letzten Jahren kontinuierlich erhöht, und es besteht Grund zur Annahme, dass sich diese Entwicklung in der Zukunft fortsetzt. Während also die physische Leistung von Datenspeichern enorm erhöht wurde, hat deren logische und organisatorische Leistung seit der Erfindung der ersten Personal Computer praktisch stagniert. Nach wie vor sind hierarchische Dateisysteme der de-facto-Standard für die Organisation von persönlichen Daten. Solche Dateisysteme repräsentieren Daten als diskrete Einheiten (Dateien), die Blätter eines Baums von beschrifteten Knoten (Verzeichnisse) darstellen. Die Unterteilung des persönlichen Datenraums in kleine Einheiten unterstützt die Handhabung solcher Strukturen durch den Menschen, allerdings können viele Arten von Organisationsinformation nicht adäquat in einer Baumstruktur dargestellt werden. Dies wirkt sich negativ auf die Qualität der Datenorganisation aus. Aktuelle Forschung im Bereich Personal Information Management liefert zwar mögliche Ansätze, um hierarchische Systeme zu ersetzen, tendiert jedoch manchmal dazu, die Arbeit mit Information überzuformalisieren. Dies ist insbesondere kritisch, weil der durchschnittliche Anwender von PIM-Systemen über keine Erfahrung mit komplexen logischen Systemen verfügt. Diese Arbeit präsentiert ein alternatives Organisationsmodell für persönliche Daten, die darauf abzielt, eine Balance zwischen der unstrukturierten Charakteristik von Dateisystemen und den formalen Eigenschaften von logik-basierten Systemen zu finden. Nach einer vergleichenden Studie der aktuellen Forschungssituation im Bereich Semantic Desktop und Personal Information Management wird dieses Modell auf drei Ebenen vorgestellt. Zunächst wird ein abstraktes Modell sowie eine Abfrage-Algebra in Form von abstrakten Operationen auf dieses Modell vorgestellt. Dieses Modell erlaubt die Abbildung von im Personal Information Management gebräuchlichen Daten, aber erfordert keine völlige Umstellung auf Seiten des Benutzers. Anschließend wird dieses abstrakte Modell in konkreten Repräsentationen übergeführt, und es wird gezeigt, wie diese Repräsentationen effizient bearbeitet, gespeichert, und ausgetauscht werden können. Schließlich wird die Anwendung dieses Modells anhand von konkreten prototypischen Implementierungen gezeigt.