gebhart/patrepeval huggingface dataset:
Effects of T cell depletion in radiation bone marrow chimeras. III. Characterization of allogeneic bone marrow cell populations that increase allogeneic chimerism independently of graft-vs-host disease in mixed marrow recipients. (1989)

The opposing problems of graft-vs-host disease vs failure of alloengraftment severely limit the success of allogeneic bone marrow transplantation as a therapeutic modality. We have recently used a murine bone marrow transplantation model involving reconstitution of lethally irradiated mice with mixtures of allogeneic and syngeneic marrow to demonstrate that an allogeneic bone marrow subpopulation, removed by T cell depletion with rabbit anti-mouse brain serum and complement (RAMB/C), is capable of increasing levels of allogeneic chimerism. This effect was observed in an F1 into parent genetic combination lacking the potential for graft-vs-host disease, and radiation protection studies suggested that it was not due to depletion of stem cells by RAMB/C. We have now attempted to characterize the cell population responsible for increasing allogeneic chimerism in this model. The results indicate that neither mature T cells nor NK cells are responsible for this activity. However, an assay involving mixed marrow reconstitution in an Ly-5 congenic strain combination was found to be more sensitive to small degrees of stem cell depletion than radiation protection assays using three-fold titrations of bone marrow cells. Using this assay, we were able to detect some degree of stem cell depletion by treatment with RAMB/C, but not with anti-T cell mAb. Nevertheless, if the effects of alloresistance observed in this model are considered, the degree of stem cell depletion detected by such mixing studies in insufficient to account for the effects of RAMB/C depletion on levels of allogeneic chimerism, suggesting that another cell population with this property remains to be identified.
Dental implants in periodontal care. (1993)

Dental implants are becoming more commonly used in periodontal offices. The literature related to implants this past year was filled with important material that will change the way we diagnose and formulate treatment plans. This review covers the key points that must be understood to maximize success with dental implants.
Synthesis of L-669,262, a Potent HMG-CoA Reductase Inhibitor (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of L-669,262, a Potent HMG-CoA Reductase InhibitorGerald E. StokkerCite this: J. Org. Chem. 1994, 59, 20, 5983–5986Publication Date (Print):October 1, 1994Publication History Published online1 May 2002Published inissue 1 October 1994https://pubs.acs.org/doi/10.1021/jo00099a030https://doi.org/10.1021/jo00099a030research-articleACS PublicationsRequest reuse permissionsArticle Views260Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Ein Beitrag zum Mechanismus der Kondensation von o‐Diaminen mit Alloxan und Dimethyl‐alloxan (1955)

Abstract Während die Kondensationen von o ‐Phenylendiamin und 4.5‐Diamino‐1.3‐dimethyl‐uracil mit Alloxan bzw. Dimethyl‐alloxan in saurem Medium nach dem gleichen Mechanismus ablaufen, findet in neutraler Lösung im Falle des Dimethyl‐alloxans primär eine Aufspaltung in Mesoxalsäure‐monomethylamid statt, das dann die Kondensationen eingeht. Bei Umsetzungen des Mesoxalsäure‐monomethylamids mit heterocyclischen o ‐Diaminen, die verschieden stark basische Aminogruppen enthalten, können durch Variation der Reaktionsbedingungen die beiden möglichen Isomeren erhalten werden.
Efficient half-harmonic generation of three-optical-cycle mid-IR frequency comb around 4 µm using OP-GaP (2018)

We report a broadband mid-infrared frequency comb with three-optical-cycle pulse duration centered around 4.2 µm, via half-harmonic generation using orientation-patterned GaP (OP-GaP) with ~43% conversion efficiency. We experimentally compare performance of GaP with GaAs and lithium niobate as the nonlinear element, and show how properties of GaP at this wavelength lead to generation of the shortest pulses and the highest conversion efficiency. These results shed new light on half-harmonic generation of frequency combs, and pave the way for generation of short-pulse intrinsically-locked frequency combs at longer wavelengths in the mid-infrared with high conversion efficiencies.
Compact Silicon Photonic Phase Modulators based on Epsilon-Near_Zero Materials. (2019)

Abstract not provided.
Using reinforcement learning to learn how to play text-based games (2018)

The ability to learn optimal control policies in systems where action space is defined by sentences in natural language would allow many interesting real-world applications such as automatic optimisation of dialogue systems. Text-based games with multiple endings and rewards are a promising platform for this task, since their feedback allows us to employ reinforcement learning techniques to jointly learn text representations and control policies. We present a general text game playing agent, testing its generalisation and transfer learning performance and showing its ability to play multiple games at once. We also present pyfiction, an open-source library for universal access to different text games that could, together with our agent that implements its interface, serve as a baseline for future research.
Methanol fuel modification for highway vehicle use. Final report (1978)

A number of problems that might occur if methanol were used as a blending stock or replacement for gasoline in present cars are identified and characterized as to the probability of their occurring and the severity of their consequences. Possibilities for correcting several problems are reported. Some problems are responsive to fuel modification but others require or are better dealt with by modification of vehicles and the bulk fuel distribution system. Phase separation on exposure to water and increased tendency to vapor lock, two major problems with blends, can both be alleviated by incorporation of cosolvent higher alcohols, ones which can be produced with methanol when it is manufactured from synthesis gas. Fuels consisting mostly of methanol require some modification of gasoline engines if the engines are to operate. If such modifications were made, starting cars at low temperatures would still be a problem. Startability can be provided by adding gasoline or light hydrocarbons; these increase the susceptibility of the fuel to vapor lock but not beyond tolerable limits. Addition of gasoline also alleviates other problems related to toxicity and safety hazards. Still other problems of both blends and methanol-rich fuels can be treated with selected additives. Some observations have been made on differences between methanol and ethanol in gasoline blends. An extension of the work is planned to study problems and corrective measures with ethanol-containing fuels.
Energy-efficient and performance-enhanced disks using flash-memory cache (2007)

This work explores the unique characteristics of flash memory in serving as a cache layer for disks. The experiments show that the proposed management scheme could save up to 20% energy consumption while reduce the read response time by the two third and the write response time by the five sixth of their counterparts. The estimated lifetime of the flash-memory cache is significantly improved as well.
A fanout optimization algorithm based on the effort delay model (2003)

This paper presents a Logical Effort-based fanout OPtimizer for ARea and Delay (LEOPARD), which relies on the availability of a (near) continuous size buffer library. Based on the concept of logical effort in very large scale integrated circuits, the proposed algorithm attempts to minimize the total buffer area under the required time and input capacitance constraints by constructing the fanout tree topology and assigning the buffer sizes. More precisely, the proposed algorithm produces the optimum fanout tree solution if the fanout tree topology is restricted to a chain of buffers. For the case where a discrete size library of buffers is available, this paper also presents a postprocessing (buffer merging) step that transforms the continuous buffer-sizing solution to a discrete one while minimizing the round-off error. Experimental results show that compared with previous approaches, both for continuous and discrete buffer libraries, LEOPARD achieves a significant reduction in the total buffer area subject to the required time constraints.
Introduction (2010)

Syncretism - the synthesis of different religious - is a contentious word. Some regard it as a pejorative term, referring to local versions of notionally standard `world religions' which are deemed `inauthentic' because saturated with indigenous content. Syncretic versions of Christianity do not conform to `official' (read `European') models. In other contexts however, the syncretic amalgamation of religions may be validated as a mode of resistance to colonial hegemony, a sign of cultural survival, or as a means of authorising political dominance in a multicultural state. In Syncretism/Anti-Syncretism the contributors explore the issues of agency and power which are integral to the very process of syncretism and to the competing discourses surrounding the term.
Parameters for assessing vibration-induced cardiovascular responses in awake dogs (1977)

The vibration parameters for assessing the response of the cardiovascular system to whole-body vibration were studied. Six awake, chronically instrumented canines were restrained with their spines vertical, and exposed to GZ sinusoidal vibration of 2-12 HZ for a constant peak acceleration amplitude of +-1.0 G. Vibration exposures of 30 s with intervening recovery periods of 2 min were employed. The following variables were measured: mean heart rate (MHR), stroke volume (SV), mean aortic flow (MAF), mean aortic pressure (MAP), the peak net force transmitted to the canine/body weight (PNF/BW), and the vibration platform frequency (ft), displacement, and acceleration. The percentage change from control (no vibration) of MAF varied linearly with PNF/BW for all cases. MAF also varied linearly with the log MHR/ft for the number of dogs which primarily changed MHR during the vibration exposures. The response of MAP was minimal in all cases, indicating a decrease in total peripheral resistance with increasing PHF.
Heavy oil recovery by CO/sub 2/ application from Bat1 Raman Field, Turkey (1983)

Bat1 Raman Oil Field, in southeastern Turkey, contains 1.85 billion STB of heavy oil in place. The reservoir represents Turkey's biggest single oil reserve. The rapid production decline of the field and increases in the price of crude oil has led TPAO to consider intervening with enhanced oil recovery techniques. Since 1967 various recovery schemes have been attempted including steam and water injection. Extensive laboratory, modeling and comparative engineering studies of various techniques resulted on immiscible CO/sub 2/ application. The paper presents the reservoir engineering aspects of immiscible CO/sub 2/ application as applied to Bat1 Raman Oil Field.
Simplified analogs of the antimalarial artemisinin: synthesis of 6,9-desmethylartemisinin (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSimplified analogs of the antimalarial artemisinin: synthesis of 6,9-desmethylartemisininMitchell A. Avery, Clive Jennings-White, and Wesley K. M. ChongCite this: J. Org. Chem. 1989, 54, 8, 1792–1795Publication Date (Print):April 1, 1989Publication History Published online1 May 2002Published inissue 1 April 1989https://pubs.acs.org/doi/10.1021/jo00269a009https://doi.org/10.1021/jo00269a009research-articleACS PublicationsRequest reuse permissionsArticle Views429Altmetric-Citations49LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Establishment of a novel CCR5 and CXCR4 expressing CD4+ cell line which is highly sensitive to HIV and suitable for high-throughput evaluation of CCR5 and CXCR4 antagonists (2004)

Thus, the U87.CD4.CCR5.CXCR4 cell line should be useful in the evaluation of CCR5 and CXCR4 antagonists with therapeutic potential and combinations thereof.
Correlation of placental microsomal activities with protein detected by antibodies to rabbit cytochrome P-450 isozyme 6 in preparations from humans exposed to polychlorinated biphenyls, quaterphenyls, and dibenzofurans. (1986)

Placental tissues were obtained from Chinese women in Taiwan who had been exposed to contaminated rice oils containing polychlorinated biphenyls and their thermal degradative products. Exposure via the diet occurred 4-5 years prior to pregnancy. Placental microsomal fractions from eight of the nine exposed subjects studied showed marked elevation of benzo(a)pyrene hydroxylation and 7-ethoxyresorufin O-deethylation activities related to control subjects. Placental microsomes from exposed subjects were found to contain a protein that cross-reacted with antibodies raised to rabbit cytochrome P-450 isozyme 6, an isozyme induced by polycyclic aromatic hydrocarbons. This protein was not observed with microsomal samples from control subjects. A significant correlation was found between the relative amounts of the immunoreactive protein and benzo(a)-pyrene hydroxylation and 7-ethoxyresorufin O-deethylation activities. The 7-ethoxyresorufin O-deethylation activities were inhibited by alpha-naphthoflavone, a compound known to inhibit activities of rabbit cytochrome P-450, isozyme 6.
Photon Scalar Irradiance (1972)

Photon scalar irradiance h is defined as the total number of photons per unit time and area arriving at a point from all directions about the point when all directions are weighted evenly. Reasons for considering photon scalar irradiance an optimum measure of radiant energy available for photosynthesis are briefly reviewed. A new technique for the measurement of h and considerations for calibrating an underwater photon scalar irradiance collector on an absolute basis are outlined.
Addition of Chloride to a Prepartal Diet High in Cations Increases 1,25-Dihydroxyvitamin D Response to Hypocalcemia Preventing Milk Fever (1991)

In this study, we present evidence that cows fed highly cationic diets are less responsive to parathyroid hormone than those fed a highly anionic diet. Forty-seven Jersey cows (55 mo of age) were fed an alfalfa haylage-based diet supplemented with either anions (Cl-) or cations (Na+). Cows fed the high cationic diet suffered significantly more cases of milk fever (6 out of 23) than those fed the high anionic diet (1 out of 24). Concentrations of Ca at parturition and the first 2 d of lactation were significantly higher in cows fed the anionic diet. Secretion of parathyroid hormone in response to developing hypocalcemia was similar in cows fed either diet. Plasma hydroxyproline concentration (an index of bone Ca resorption activity) was greater in cows fed the anionic diet, suggesting better utilization of bone Ca. Plasma 1,25-dihydroxyvitamin D concentration was correlated inversely with plasma Ca and related directly to plasma parathyroid hormone in both groups of cows. However, the magnitude of the response (the amount of 1,25-dihydroxyvitamin D produced per unit increase in parathyroid hormone) was reduced greatly in cows fed the high cation diet. Because parathyroid hormone regulates both bone Ca resorption and renal 1,25-dihydroxyvitamin D production, these data suggest that prepartal diets high in cations decrease the ability of bone and renal tissues to respond to parathyroid hormone. Addition of anions to prepartal diets can reduce the excess cation balance of diets, increasing tissue response to parathyroid hormone and enabling the cow to better adapt to the Ca demands of lactation.
Pressure cycling technology:a novel approach to virus inactivation in plasma (2000)

High-pressure procedures may be useful for the inactivation of viruses in blood and other protein-containing components.
High-Performance Germanium-an-Silicon Lock-in Pixels for Indirect Time-of-Flight Applications (2018)

We investigate and demonstrate the first Ge-on-Si lock-in pixels for indirect time-of-flight measurements. Compared to conventional Si lock-in pixels, such novel Ge-on-Si lock-in pixels simultaneously maintain a high quantum efficiency and a high demodulation contrast at a higher operation frequency, which enable consistently superior depth accuracies for both indoor and outdoor scenarios. System performances are evaluated, and pixel quantum efficiencies are measured to be >85% and >46% at 940nm and 1550nm wavelengths, respectively, along with demodulation contrasts measured to be >0.81 at 300MHz. Our work may open up new routes to high-performance indirect time-of-flight sensors and imagers, as well as potential adoptions of eye-safe lasers (e.g. wavelengths > 1.4μm)) for consumer electronics and photonics.
Technique for measurement of water activity in the high Aw range (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTechnique for measurement of water activity in the high Aw rangePatricia T. Vos and Theodore P. LabuzaCite this: J. Agric. Food Chem. 1974, 22, 2, 326–327Publication Date (Print):March 1, 1974Publication History Published online1 May 2002Published inissue 1 March 1974https://pubs.acs.org/doi/10.1021/jf60192a016https://doi.org/10.1021/jf60192a016research-articleACS PublicationsRequest reuse permissionsArticle Views414Altmetric-Citations45LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Optimization of non‐isotopic <i>in situ</i> hybridization on formalin‐fixed, paraffin‐embedded material using digoxigenin‐labelled probes and transgenic tissues (1992)

The sensitivity of non-isotopic in situ hybridization (NISH), particularly on formalin-fixed, paraffin-embedded (FFPE) clinical tissues, has been the subject of controversy. Generally, NISH has been regarded as being less sensitive than radiolabelled procedures, although some reports have contradicted this. Accordingly, tissues from mice which were transgenic for variable amounts of the human alpha-1-antitrypsin gene were used to optimize the NISH procedure and to estimate the sensitivity. This approach showed that prolonged incubation of slides in final substrate resulted in high sensitivity--about 13 kb of target DNA. However, this prolonged incubation crucially depended on achieving minimal non-specific background staining. Many factors affected the degree of background staining, but five were particularly important. First, the method of mounting cut sections onto slides. Second, the length of the probe (ideally less than 400 bp). Third, the procedure for proteolytic digestion. Fourth, the denaturation technique, and fifth, the quality of the dextran sulphate used in the hybridization mix. The optimized protocol showed variable patterns of mRNA distribution in the transgenic mouse livers, while DNA distribution appeared uniform.
An approach for secure edge computing in the Internet of Things (2017)

In this paper, we discuss the singular characteristics of the Internet of Things (IoT) in regard to security issues and present a security architecture with special focus on Edge networks and Smart Things. The architecture is based on the assumption that data integrity, authentication, and service/device access control are the most important aspects that have to be guaranteed for safe operation of highly decentralized and heterogeneous IoT systems. The architecture is made concrete as an extension of the ContextNet middleware for IoT. This middleware has a cloud and a mobile component and advocates the use of smartphones - or devices that execute smartphone platforms - as the universal gateways between cloud-hosted IoT services and the Smart Things. In addition to general architecture, the other major contribution is a protocol for establishing a secure connection between the Smart Things and these mobile gateways.