gebhart/patrepeval huggingface dataset:
Trial Prospector: Matching Patients with Cancer Research Studies Using an Automated and Scalable Approach (2014)

Cancer is responsible for approximately 7.6 million deaths per year worldwide. A 2012 survey in the United Kingdom found dramatic improvement in survival rates for childhood cancer because of increased participation in clinical trials. Unfortunately, overall patient participation in cancer clinical studies is low. A key logistical barrier to patient and physician participation is the time required for identification of appropriate clinical trials for individual patients. We introduce the Trial Prospector tool that supports end-to-end management of cancer clinical trial recruitment workflow with (a) structured entry of trial eligibility criteria, (b) automated extraction of patient data from multiple sources, (c) a scalable matching algorithm, and (d) interactive user interface (UI) for physicians with both matching results and a detailed explanation of causes for ineligibility of available trials. We report the results from deployment of Trial Prospector at the National Cancer Institute (NCI)-designated Case Comprehensive Cancer Center (Case CCC) with 1,367 clinical trial eligibility evaluations performed with 100% accuracy.
Complexes of carbohydrates with metal cations. V. Syntheses of methyl glycosides in the presence of metal ions (1975)

By the use of complexing with calcium or strontium ions to alter the anomeric equilibria, the following methyl glycosides have been synthesized in good yield: methyl a-D-ribofuranoside, ß-D-lyxo- furanoside and -pyranoside, a- and ß-D-mannofuranoside, a-D- talopyranoside, a- and ß-D-talo-furanoside, a-L-gulo-furanoside and- pyranoside, and all the four methyl glycosides of D-glycero-D-gulo- heptose.
Preferential replication of HIV-1 in the CD45RO memory cell subset of primary CD4 lymphocytes in vitro. (1997)

The ability of HIV-1 to establish an infection and replicate to high copy number in CD4 lymphocytes is dependent on both the activation state of the cell and virus-encoded regulatory proteins that modulate viral gene expression. To study these required virus-cell interactions, we have used an in vitro cell model of acute HIV infection of quiescent, primary CD4 lymphocytes and subsequent induction of T cell activation and virus replication by lectin or CD3 receptor cross-linking. Experiments were done to determine if the capacity of HIV to establish infection and complete replication was impacted by the maturational state of the CD4 cell target or the specific signal induction pathway engaged during activation. Primary CD4 cells were FACS-sorted into the major phenotypic subsets representative of memory (CD45RO) and naive (CD45RA) cells. Levels of virus replication were compared between infection with wild-type NL4-3 virus and an isogenic mutant containing a deletion in nef regulatory gene. PHA mitogen stimulation was compared with anti-CD3, with and without anti-CD28 costimulation, for induction of cell proliferation and virus replication. In both infected and uninfected cells, the RA cell subset exhibited significantly greater response to CD3/CD28 stimulation than did the RO cell subset. In contrast, the majority of virus replication occurred consistently in the RO cell subset. Deletion of HIV nef function caused a severe reduction in viral replication, especially in the RA naive cell subset after CD3 induction. PCR analysis of viral DNA formation, during infection of quiescent cells, demonstrated that the observed differences in HIV replication capacity between RO and RA cell subsets were not due to inherent differences in cell susceptibility to infection. Our results indicate that HIV replication is enhanced selectively in CD45RO memory phenotype cells through the probable contribution of specialized cellular factors which are produced during CD3-initiated signal transduction.
The English <i>get</i>-passive in spoken discourse: description and implications for an interpersonal grammar (1999)

Using a 1.5-million-word sample from the CANCODE spoken English corpus, we present a description of the get -passive in informal spoken British English. Previous studies of the get -passive are reviewed, and their focus on contextual and interpersonal meanings is noted. A number of related structures are then considered and the possibility of a passive gradient is discussed. The corpus sample contains 139 get -passives of the type X get + past participle (by Y) ( e.g. He got killed ), of which 124 occur in contexts interpreted as adversative or problematic from the speaker's viewpoint. Very few examples contain an explicit agent or adverbials. Main verb frequency is also considered. Where contexts are positive rather than adversative, newsworthiness or focus of some kind on the subject and/or events is still apparent. The corpus evidence is used to evaluate the terms upon which an interpersonal grammar of English might be developed, and a contrast is drawn between deterministic grammars and probabilistic ones, with probabilistic grammars offering the best potential for the understanding of interpersonal features.
Annulation of Pyridine to Indole by A Tandem Aza-Wittig/Electrocyclization Strategy: Synthesis of Pyrido[2,3-<i>b</i>]indoles (1989)

Iminophosphorane 2, prepared form 1 and nitromethane, reacts with isocyanates to give directly 2-alkyl(aryl)amino-3-nitro-9-phenyl-9H-pyrido [2,3-b]indoles 5.
Oral squamous cell carcinoma invasion is associated with a laminin-5 matrix re-organization but independent of basement membrane and hemidesmosome formation. clues from an in vitro invasion model. (1997)

The basement membrane (BM) molecule laminin-5 represents the major component of the anchoring filaments, the BM counterpart of the hemidesmosomes. Because laminin-5 is abundantly deposited adjacent to budding invasive carcinoma cells in vivo, a special invasion-promoting role is suspected. We present a 3D collagen type I gel invasion model for oral squamous cell carcinoma (OSCC) using the newly established OSCC cell lines PE/CA-PJ15, PE/CA-PJ34, and PE/CA-PJ41. The carcinoma cells on the surface of the collagen type I gel show an invasive growth exclusively in the presence of gel-inoculated (myo)fibroblasts yielded from nodular palmar fibromatosis or tumour stroma. The model is characterized by an immunohistochemical and ultrastrcutural failure of structural BM and hemidesmosome formation. In the model an invasion-associated modulation of the laminin-5 deposition (alpha3, clone BM165; gamma2, clone GB3) was demonstrated: in invasive areas a strong ribbon-like immunostaining in the tumor-gel interface. The results obtained from the invasion model suggest that the assumed invasion-promoting ability of the BM molecule laminin-5 is realized independent of a structural BM and hemidesmosome formation.
Emergence of differentiated subclones from a human salivary adenocarcinoma cell clone in culture after treatment with sodium butyrate. (1986)

A human salivary gland adenocarcinoma cell line, which has ultrastructure and biological markers specific to the intercalated duct cells of human salivary glands, was cultured in 5 mM sodium butyrate for 12 days; then the cells were trypsinized, subcultured for an additional 16 days, and then transferred to growth medium without sodium butyrate. Morphological changes appeared about 1 wk after return to growth medium without sodium butyrate; cells being spindle or stellate in shape appeared in the treated cells, whereas the untreated cells were polygonal in shape. This morphologically altered phenotype persists after more than 14 mo of culture in growth medium without sodium butyrate. Of 40 subclones isolated, 2 clonal cell lines were established from the subculture and characterized. The other 38 subclones were accompanied by cell death during the subcultures. The clonal lines exhibited a phenotype similar to myoepithelial cells such as myosin, beta-chain of S-100 protein, myofilaments, and oxytocin receptor in addition to decreased tumorigenicity and anchorage-independent growth. These findings indicate that commitment to differentiation into myoepithelial cells and conversion from malignant to normal phenotype occur in a human salivary gland adenocarcinoma cell line following the sodium butyrate treatment.
Recent Advances in Flip-Chip Underfill: Materials, Process, and Reliability (2004)

In order to enhance the reliability of a flip-chip on organic board package, underfill is usually used to redistribute the thermomechanical stress created by the coefficient of thermal expansion (CTE) mismatch between the silicon chip and organic substrate. However, the conventional underfill relies on the capillary flow of the underfill resin and has many disadvantages. In order to overcome these disadvantages, many variations have been invented to improve the flip-chip underfill process. This paper reviews the recent advances in the material design, process development, and reliability issues of flip-chip underfill, especially in no-flow underfill, molded underfill, and wafer-level underfill. The relationship between the materials, process, and reliability in these packages is discussed.
A Study of Design Parameters for Flood Hydrograph Models (1989)

Flood hydrograph models, such as unit hydrograph or runoff routing models, are applied to two quite different types of flood estimation. The first involves estimation of the surface runoff hydrograph resulting from a recorded storm rainfall hyetograph, while the second case involves design flood estimation using a design storm rainfall. Most information on model parameters concerns the first case and very little information is available for the second case. To enable flood hydrograph models to be used for design flood estimation, information on design parameter values is needed. In this study, flood frequency data from 36 catchments in New South Wales was used, together with design rainfall data from Australian Rainfall and Runoff 1987, to derive design parameters for a range of average recurrence intervals. When using design rainfall intensities, temporal patterns and losses, values of the design parameters were found to vary with the average recurrence interval of the flood. This variation depended on the degree of nonlinearity present in the model. Despite the considerable differences in the two approaches to flood estimation, the design parameters were found, on average, to agree with parameters derived from recorded events. Design parameter values were also found to be consistent with regression equations between recorded parameters and catchment characteristics.
Zur Kenntnis neuer Brenzcatechine und ortho-Chinone (1963)

Es werden Synthesen und Eigenschaften einiger neuer Brenzcatechine und ortho-Chinone beschrieben. Wie der eine von uns mit LEY 1 bereits früher beobachtete, werden bei der Komproportionierung von sterisch gehinderten ortho-Chinonen und Brenzcatechin-Derivaten stabile Semichinone erhalten: Inzwischen haben wir die Eigenschaften solcher „polarer Sauerstoffradikale“ näher untersucht und werden in Kürze ausführlicher darüber berichten. Zur Herstellung der Semichinone benötigten wir einige bislang unbekannte ortho-Chinone bzw. Brenzcatechine, deren Synthesen und Eigenschaften wir im folgenden mitteilen möchten.
Transforming Growth Factor-β Inhibits Interferon-γ Secretion by Lymph okine-activated Killer Cells Stimulated with Tumor Cells (1996)

The effect of transforming growth factor-beta (TGF-beta) secreted by glioblastoma (T98G) cells on the secretion of interferon-gamma (IFN-gamma) by lymphokine-activated killer (LAK) cells stimulated with tumor cells was investigated in cocultures of LAK and Daudi cells supplemented with T98G culture supernatant, T98G culture supernatant preincubated with anti-TGF-beta 1 and anti-TGF-beta 2 neutralizing antibodies, anti-TGF-beta 1 and anti-TGF-beta 2 antibodies, or natural human TGF-beta 1 or recombinant human TGF-beta 2. LAK cells were incubated with anti-TGF-beta 1 and anti-TGF-beta 2 antibodies, and with T98G cells of which the supernatant contained both active and latent forms of TGF-beta 1 and TGF-beta 2, with or without neutralizing antibodies. Addition of the supernatant from T98G cells to LAK/Daudi culture caused inhibition of IFN-gamma secretion by LAK cells. The inhibition was abolished by pretreatment of the supernatants with anti-TGF-beta antibodies. Addition of TGF-beta 1 and TGF-beta 2 to the LAK/Daudi culture inhibited IFN-gamma secretion by LAK cells in a dose-dependent manner. Addition of anti-TGF-beta antibodies to the LAK culture resulted in increased IFN-gamma secretion. T98G cells failed to stimulate LAK cells to secrete more IFN-gamma. Addition of anti-TGF-beta antibodies to the LAK-T98G culture resulted in increased IFN-gamma secretion by LAK cells. These results suggest that most malignant glioma cells which secrete high levels of TGF-beta can inhibit IFN-gamma secretion by LAK cells even after tumor cell stimulation.
Taking the Skeletons Out of the Closets: A Simple and Efficient Topology Discovery Scheme for Large Ethernet LANs (2009)

We propose a simple and efficient algorithmic solution for discovering the physical topology of large, heterogeneous Ethernet LANs that may include multiple subnets as well as uncooperative network elements, like hubs. Our scheme utilizes only generic MIB information and <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">does not</i> require any hardware or software modification of the underlying network elements. By rigorous analysis, we prove that our method correctly infers the network topology and has low communication and computational overheads. Our simulation results show that the scheme successfully infers the complete topology in the vast majority of the cases, including many instances that cannot be inferred by other methods. Finally, our proof-of-concept implementation demonstrates the practicality of the proposed scheme for network management.
Improvements in the properties of internal-tin Nb/sub 3/Sn (1997)

A review is given of the present status of Stage IV of the strand production at IGC for the Central Solenoid (CS) Model Coil for the International Thermonuclear Experimental Reactor, (ITER). The design of this production strand was essentially frozen more than a year ago but a parallel development program has been carried out to improve the properties of internal-tin processed Nb/sub 3/Sn for fusion and other applications. The H/sub cl/* and T/sub c/* have been raised, the J/sub c/ controlled over a wide range of values, and the losses lowered in a number of different ways. An examination of the microstructure and electrical properties after a series of different thermomechanical treatments has been carried out and some of the preliminary results are described.
State of the art of virtual reality technology (2016)

In the past three years, the so-called second wave of Virtual Reality (VR) has brought us a vast amount of new displays and input devices. Not only new hardware has entered the consumer market providing affordable pricing models but also completely new technologies are being designed and developed. Additionally new concepts for handling existing problems on the hardware and software side of the VR technology are constantly being introduced. This software and hardware development is mainly lead by enthusiasts interested in the domain of VR opposed to the established scientific community, which already partially makes use of the newly available technology. Besides Head-Mounted Displays (HMDs), either cable-based or mobile, other devices like haptics devices, controllers, vests, omnidirectional treadmills, tracking technologies, as well as optical scanners for gesture-based interaction are gaining importance in the field of commodity VR. Most of these technologies are already precise and robust enough to be used for professional operation and scientific experiments. The topics discussed are the common issues with the new technologies including the approaches to solve them as for example motion-to-photon latency, barrel distortion, and low-persistence displays. Additionally an in-depth analysis of the available solutions expected to hit the market is provided. A taxonomy categorising the current developments with the chosen implementation approaches will be given. The paper analyses the state of technological advancements in the field and provides an extensive overview on the current development considering the upcoming devices and the advancements from the software side.
Salve, Flos Doctorvm! - Phanis I. Kakridis: Ἡ παρ⋯ταξη τ⋯ν οὐσιαστικ⋯ν στ⋯ν Ὄμηρο κα⋯ στοὺς Ὁμηρικοὺς Ὕμνους. (Ἐπιστημονικ⋯ Ἐπετηρ⋯ς τ⋯ς Φιλοσοφικ⋯ςᾣχολ⋯ς, Supplement No. 4.) Pp. (viii)+118+vi. Thessaloniki: Panepistemion, 1960. Paper. (1962)

Salve, Flos Doctorvm! - Phanis I. Kakridis: Ἡ παρ⋯ταξη τ⋯ν οὐσιαστικ⋯ν στ⋯ν Ὄμηρο κα⋯ στοὺς Ὁμηρικοὺς Ὕμνους. (Ἐπιστημονικ⋯ Ἐπετηρ⋯ς τ⋯ς Φιλοσοφικ⋯ςᾣχολ⋯ς, Supplement No. 4.) Pp. (viii)+118+vi. Thessaloniki: Panepistemion, 1960. Paper. - Volume 12 Issue 3
Oral administration of a combination of select lactic acid bacteria strains to reduce the Salmonella invasion and inflammation of broiler chicks (2012)

One-day-old chicks are susceptible to infection by strains of Salmonella enterica subspecies. Because multistrain probiotics are suggested to be more effective than monostrain probiotics due to the additive and synergistic effects, in this study, we prepared a multistrain formula A (MFA) consisting of 4 lactic acid bacteria (LAB) strains selected by enhancing the TNF-α production for mouse macrophage 264.7 cells. The antagonistic effect of this MFA against the cecal colonization, viscera invasiveness, as well as the inflammation of 1-d-old chicks challenged with Salmonella Typhimurium were then assayed. One-day-old chicks were fed with MFA from d 1 to d 3, and on d 4, chicks were challenged with Salmonella Typhimurium (200 μL, 10(6) cfu/mL). The livers, spleens, and cecal tonsils of chicks were then removed on d 3 and 6 postinfection. Compared with the multistrain formula B (MFB) which consisted of LAB strains selected at random, the efficacy of MFA to reduce the Salmonella counts recovered from the cecal tonsils, spleens, and livers of chicks were significantly higher. Moreover, when the levels of proinflammatory cytokines, such as IL-1β, IL-6, interferon (IFN)-γ, and anti-inflmmatory cytokine, that is, IL-10, in cecal tonsils were measured by reverse-transcription real-time quantitative PCR; it was found that chicks fed with MFA for 3 d had lower levels of IL-1β, IL-6, IFN-γ and a higher level of IL-10 in the cecal tonsils of chicks as compared with those of the chicks fed with MFB or without LAB. These results suggest that multistrain probiotics consisting of LAB strains selected by immunomodulatory activity and adherence are more effective than those consisting of strains selected at random in antagonistic effect against Salmonella colonization, invasion, and the induced inflammation.
Global value numbers and redundant computations (1988)

Article Free Access Share on Global value numbers and redundant computations Authors: B. K. Rosen IBM Thomas J. Watson Research Center, Yorktown Heights, NY IBM Thomas J. Watson Research Center, Yorktown Heights, NYView Profile , M. N. Wegman IBM Thomas J. Watson Research Center, Yorktown Heights, NY IBM Thomas J. Watson Research Center, Yorktown Heights, NYView Profile , F. K. Zadeck Department of Computer Science, Brown University, Providence, RI Department of Computer Science, Brown University, Providence, RIView Profile Authors Info & Claims POPL '88: Proceedings of the 15th ACM SIGPLAN-SIGACT symposium on Principles of programming languagesJanuary 1988 Pages 12–27https://doi.org/10.1145/73560.73562Published:13 January 1988Publication History 278citation1,997DownloadsMetricsTotal Citations278Total Downloads1,997Last 12 Months240Last 6 weeks26 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
A History of Indian Philosophy. By Surendranath Dasgupta. 9 × 6½, pp. xii + 620. Cambridge: Cambridge University Press. 1932. 35<i>s</i>. (1934)

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Possible hemostatic effect of synthetic liposomes in experimental studies under flow conditions. (2002)

These results confirm that, at an experimental level, liposomes containing phospholipids could potentially be used to improve hemostasis in patients with quantitative or qualitative platelet disorders.
Algorithms for Nonnegative Matrix Factorization with the β-Divergence (2011)

This letter describes algorithms for nonnegative matrix factorization (NMF) with the β-divergence (β-NMF). The β-divergence is a family of cost functions parameterized by a single shape parameter β that takes the Euclidean distance, the Kullback-Leibler divergence, and the Itakura-Saito divergence as special cases (β = 2, 1, 0 respectively). The proposed algorithms are based on a surrogate auxiliary function (a local majorization of the criterion function). We first describe a majorization-minimization algorithm that leads to multiplicative updates, which differ from standard heuristic multiplicative updates by a β-dependent power exponent. The monotonicity of the heuristic algorithm can, however, be proven for β ∈ (0, 1) using the proposed auxiliary function. Then we introduce the concept of the majorization-equalization (ME) algorithm, which produces updates that move along constant level sets of the auxiliary function and lead to larger steps than MM. Simulations on synthetic and real data illustrate the faster convergence of the ME approach. The letter also describes how the proposed algorithms can be adapted to two common variants of NMF: penalized NMF (when a penalty function of the factors is added to the criterion function) and convex NMF (when the dictionary is assumed to belong to a known subspace).
Optical Resolution by Supercritical Fluid Chromatography Using Polysaccharide Derivatives as Chiral Stationary Phases (1992)

Abstract The optical resolution of ten racemates by supercritical fluid chromatography (SFC) was investigated using phenylcarbamates of cellulose and amylose and 4-methylbenzoate of cellulose as chiral stationary phases (CSPs) and carbon dioxide–alcohol as a mobile phase. The optical resolving abilities of phenylcarbamates of both cellulose and amylose in SFC were low compared with those in high-performance liquid chromatography (HPLC). However, 4-methylbenzoate of cellulose showed a slightly better optical resolving ability in SFC than in HPLC.
Recent advances in research on early detection, causes, biology, and treatment of autism spectrum disorders (2010)

Department of Psychiatry, University of North Carolina, Chapel Hill, North Carolina and Autism Speaks, New York, New York, USA Correspondence to Geraldine Dawson, PhD, 4120 Bioinformatics Building, CB# 3366; University of North Carolina, Chapel Hill, NC 27599-3366, USA E-mail: [email protected]