gebhart/patrepeval huggingface dataset:
Absorption of Val-Tyr with in Vitro Angiotensin I-Converting Enzyme Inhibitory Activity into the Circulating Blood System of Mild Hypertensive Subjects. (2002)

The change in plasma level of dipeptide, Val-Tyr (VY), with in vitro angiotensin I-converting enzyme inhibitory activity was investigated after a single oral administration of a VY-drink at doses of 0, 6 or 12 mg given to mild hypertensive subjects. During this protocol for up to 24 h after the intake, patient/subject blood pressure (BP) was measured for a 15 min period at designated times (0, 1, 2, 4, 8, 24 h) with the individual supine. Based on the VY determination, the maximal increment of plasma VY level was observed over the second hour postprandially (12 mg-dose; 2041+/-148 fmol/ml-plasma). In addition, the plasma VY level increased with the VY dosage. However, no marked BP change was observed with the increase of plasma VY level, suggesting that VY did not exert an acute hypotensive effect. The area under the curve at 12 mg-dose was estimated to be 8644+/-420 fmol x h/ml-plasma, comparable to that in normotensive subjects. This finding suggests that absorption of VY would not be influenced by a complaint of hypertension.
Motion Deblurring of Faces (2018)

Face analysis lies at the heart of computer vision with remarkable progress in the past decades. Face recognition and tracking are tackled by building invariance to fundamental modes of variation such as illumination, 3D pose. A much less standing mode of variation is motion deblurring, which however presents substantial challenges in face analysis. Recent approaches either make oversimplifying assumptions, e.g. in cases of joint optimization with other tasks, or fail to preserve the highly structured shape/identity information. We introduce a two-step architecture tailored to the challenges of motion deblurring: the first step restores the low frequencies; the second restores the high frequencies, while ensuring that the outputs span the natural images manifold. Both steps are implemented with a supervised data-driven method; to train those we devise a method for creating realistic motion blur by averaging a variable number of frames. The averaged images originate from the $$2MF^2$$ dataset with $$19$$ million facial frames, which we introduce for the task. Considering deblurring as an intermediate step, we conduct a thorough experimentation on high-level face analysis tasks, i.e. landmark localization and face verification, on blurred images. The experimental evaluation demonstrates the superiority of our method.
Revision for postoperative bleeding: timing and decision making (2009)

Five percent of patients require re-exploration during early postoperative period after open heart surgery. The first cause for early mediastinal re-exploration after open heart surgery is the bleeding. In this review report we evaluated the major risk factors, the decision making for revision and the frequent complications after revision for bleeding under light of the literature. To reduce the risk for bleeding and blood transfusion rates, we recommend that discontinuation of the drugs affecting platelet functions, achievement of shortest CPB time possible, recurrent effective hemostasis before closure and faster elimination of hypothermia after arrival into the intensive care unit.
Gravimetric Analysis for Determining the Resin and Rubber Content of Guayule (1983)

Abstract The method presented provides a fast and sufficiently accurate method for determining the resin and rubber contents of guayule. Although it does not provide definitive or “absolute” values that presumably can be obtained with sophisticated instrumentation, it is well suited for agronomic developmental studies at the field station level.
Blood levels of kynurenines, interleukin‐23 and soluble human leucocyte antigen‐G at different stages of Huntington’s disease (2009)

There is substantial evidence that abnormal concentrations of oxidised tryptophan metabolites, produced via the kynurenine pathway, contribute to progressive neurodegeneration in Huntington's disease. We have now examined the blood levels of these metabolites in patients at different stages of Huntington's disease, assessed both in terms of clinical disease severity and numbers of CAG repeats. Close relatives of the patients were included in the study as well as unrelated healthy controls. Levels of lipid peroxidation products, the pro-inflammatory cytokine interleukin (IL)-23 and the soluble human leucocyte antigen-G (sHLA-G) were also measured. There were lower levels of tryptophan and a higher kynurenine : tryptophan ratio, indicating activation of indoleamine-2,3-dioxygenase, in the most severely affected group of patients, with increased levels of IL-23 and sHLA-G. Marked correlations were noted between IL-23 and the patient severity group, anthranilic acid levels and the number of CAG repeats, and between anthranilic acid and IL-23, supporting our previous evidence of a relationship between anthranilic acid and inflammatory status. Tryptophan was negatively correlated with symptom severity and number of CAG repeats, and positively correlated with sHLA-G. The results support the proposal that tryptophan metabolism along the kynurenine pathway in Huntington's disease is related to the degree of genetic abnormality, to clinical disease severity and to aspects of immunopathogenesis.
Efficacy and safety of tocilizumab in COVID-19 patients (2020)

In this retrospective study we assessed the efficacy and safety of tocilizumab in patients with critical or severe coronavirus disease 2019 (COVID-19). We enrolled 181 patients admitted to Huoshenshan Hospital (Wuhan, China) with confirmed COVID-19 between January 2020 and February 2020. Ninety-two patients were treated with tocilizumab, and 89 patients were treated conventionally. We analyzed the clinical manifestations, changes in CT scan images, and laboratory tests before and after tocilizumab treatment, and compared these results with the conventionally treated group. A significant reduction in the level of C-reactive protein was observed 1 week after tocilizumab administration. In some cases this meant the end of the IL-6-related cytokine storm. In addition, tocilizumab relieved fever, cough, and shortness of breath with no reported adverse drug reactions. These findings suggest tocilizumab improves clinical outcomes and is effective for treatment of patients with critical or severe COVID-19. However, future clinical trials are needed to better understand the impact of tocilizumab interference with IL-6 and provide a therapeutic strategy for treatment of COVID-19.
Synthesis, characterization, and evaluation of poly (D,L-lactide-co-glycolide)-based nanoformulation of miRNA-150: potential implications for pancreatic cancer therapy (2014)

MicroRNAs are small (18-22 nucleotide long) noncoding RNAs that play important roles in biological processes through posttranscriptional regulation of gene expression. Their aberrant expression and functional significance are reported in several human malignancies, including pancreatic cancer. Recently, we identified miR-150 as a novel tumor suppressor microRNA in pancreatic cancer. Furthermore, expression of miR-150 was downregulated in the majority of tumor cases, suggesting that its restoration could serve as an effective approach for pancreatic cancer therapy. In the present study, we developed a nanoparticle-based miR-150 delivery system and tested its therapeutic efficacy in vitro. Using double emulsion solvent evaporation method, we developed a poly (D,L-lactide-co-glycolide) (PLGA)-based nanoformulation of miR-150 (miR-150-NF). Polyethyleneimine (a cationic polymer) was incorporated in PLGA matrix to increase the encapsulation of miR-150. Physical characterization of miR-150-NF demonstrated that these nanoparticles had high encapsulation efficiency (~78%) and exhibited sustained release profile. Treatment of pancreatic cancer cells with miR-150-NF led to efficient intracellular delivery of miR-150 mimics and caused significant downregulation of its target gene (MUC4) expression. Inhibition of MUC4 correlated with a concomitant decrease in the expression of its interacting partner, HER2, and repression of its downstream signaling. Furthermore, treatment of pancreatic cancer cells with miR-150-NF suppressed their growth, clonogenicity, motility, and invasion. Together, these findings suggest that PLGA-based nanoformulation could potentially serve as a safe and effective nanovector platform for miR-150 delivery to pancreatic tumor cells.
Ultrasonic enhancement of α/sub v/β/sub 3/ expressing-cells with targeted contrast agents (2004)

Targeted contrast agents have the potential to substantially improve the ability of ultrasound contrast agents to delineate otherwise difficult-to-detect pathologies. In this manuscript, optical microscopy and acoustic backscatter measurements from human umbilical vein endothelial cells (HUVEC) exposed to targeted and control microbubbles illustrate the high affinity of targeted agents for the /spl alpha//sub v//spl beta//sub 3/ integrin. Backscatter measurements are provided for cell layers exposed to three types of targeted contrast agents in addition to two controls. Acoustic studies illustrate a backscatter amplitude increase from /spl alpha//sub v//spl beta//sub 3/ expressing cells exposed to the targeted contrast agent of up to 13 fold compared to non-targeted agents. Additionally, echo decorrelation is shown to be a function of acoustic pressure and microbubble density. Frequency domain analysis demonstrates that adherent targeted microbubbles exhibit a significantly more narrowband spectrum than free microbubbles. These results suggest that targeted contrast agents may provide additional sensitivity in the detection of tumors, and that adherent contrast agents may be differentiable from free-floating microbubbles.
A 520k (18900, 17010) Array Dispersion LDPC Decoder Architectures for NAND Flash Memory (2015)

Although Latin square is a well-known algorithm to construct low-density parity-check (LDPC) codes for satisfying long code length, high code-rate, good correcting capability, and low error floor, it has a drawback of large submatrix that the hardware implementation will be suffered from large barrel shifter and worse routing congestion in fitting NAND flash applications. In this paper, a top-down design methodology, which not only goes through code construction and optimization, but also hardware implementation to meet all the critical requirements, is presented. A two-step array dispersion algorithm is proposed to construct long LDPC codes with a small submatrix size. Then, the constructed LDPC code is optimized by masking matrix to obtain better bit-error rate (BER) performance and lower error-floor. In addition, our LDPC codes have a diagonal-like structure in the parity-check matrix leading to a proposed hybrid storage architecture, which has the advantages of better area efficiency and large enough data bandwidth for high decoding throughput. To be adopted for NAND flash applications, an (18900, 17010) LDPC code with a code-rate of 0.9 and submatrix size of 63 is constructed and the field-programmable gate array simulations show that the error floor is successfully suppressed down to BER of 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-12</sup> . An LDPC decoder using normalized min-sum variable-node-centric sequential scheduling decoding algorithm is implemented in UMC 90-nm CMOS process. The postlayout result shows that the proposed LDPC decoder can achieve a throughput of 1.58 Gb/s at six iterations with a gate count of 520k under a clock frequency of 166.6 MHz. It meets the throughput requirement of both NAND flash memories with Toggle double data rate 1.0 and open NAND flash interface 2.3 NAND interfaces.
Adenosine Modulates Endothelin-Induced Bronchoconstriction in Guinea Pig Airway (1997)

The present study was designed to determine whether endogenous and exogenous adenosine modulates endothelin (ET)-induced bronchoconstriction. Exogenous adenosine enhances ET-induced bronchoconstriction. Following pretreatment with adenosine deaminase and theophylline to eliminate or antagonize endogenous adenosine, ET-1-induced bronchoconstriction was significantly attenuated, but not that of ET-3. In conclusion, this is the first report of an enhancement of ET-induced bronchoconstriction of guinea pig airways by endogenous and exogenous adenosine. Our findings may be useful in designing specific adenosine receptor antagonists as therapeutic agents in the management of bronchial asthma.
Unusual directive effects in the hydroboration of .beta.,.beta.-disubstituted enamines. Conversion of .alpha.-substituted aldehydes to the corresponding alkenes and .beta.-amino alcohols (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTUnusual directive effects in the hydroboration of .beta.,.beta.-disubstituted enamines. Conversion of .alpha.-substituted aldehydes to the corresponding alkenes and .beta.-amino alcoholsBakthan Singaram, Christian T. Goralski, and Gary B. FisherCite this: J. Org. Chem. 1991, 56, 19, 5691–5696Publication Date (Print):September 1, 1991Publication History Published online1 May 2002Published inissue 1 September 1991https://pubs.acs.org/doi/10.1021/jo00019a043https://doi.org/10.1021/jo00019a043research-articleACS PublicationsRequest reuse permissionsArticle Views485Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Real-Time Remote Onboard Diagnostics Using Embedded GPRS Surveillance Technology (2007)

Onboard-diagnostic (OBD) system is developed to detect engine operation conditions for air-pollution monitoring. The diagnostic trouble code from vehicle microprocessor is generated resulting from a system error or malfunction. Based on a practical demand, this paper presents a modified system construction from vehicle surveillance technology for OBD data report in real time. A circuit system is designed and fabricated to convert OBD protocol into RS-232 protocol for data transmission via general-packet-radio-service mobile communication. The proposed system integrates the developing technology for both OBD and intelligent-transportation-system applications. In this paper, hardware and software in both design and implementation are discussed and verified by road tests
Optically active amines. 31. Spectral observations on the substituted benzene chromophore (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOptically active amines. 31. Spectral observations on the substituted benzene chromophoreHoward E. Smith, Jon R. Neergaard, Tomas De Paulis, and Fu Ming ChenCite this: J. Am. Chem. Soc. 1983, 105, 6, 1578–1584Publication Date (Print):March 1, 1983Publication History Published online1 May 2002Published inissue 1 March 1983https://pubs.acs.org/doi/10.1021/ja00344a026https://doi.org/10.1021/ja00344a026research-articleACS PublicationsRequest reuse permissionsArticle Views285Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A database disk buffer management algorithm based on prefetching (1998)

Article Free Access Share on A database disk buffer management algorithm based on prefetching Authors: H. Seok Jeon Department of Computer Engineering, Hong-Ik University, Mapo-Gu Sangsoo Dong 72-1 Seoul, Korea 121-791, and Thinkware Systems Corp., Poi-Dong 196-2, Kangnam-Gu, Seoul, Korea 135-260 Department of Computer Engineering, Hong-Ik University, Mapo-Gu Sangsoo Dong 72-1 Seoul, Korea 121-791, and Thinkware Systems Corp., Poi-Dong 196-2, Kangnam-Gu, Seoul, Korea 135-260View Profile , Sam H. Noh Department of Computer Engineering, Hong-Ik University, Mapo-Gu Sangsoo Dong 72-1 Seoul, Korea 121-791 Department of Computer Engineering, Hong-Ik University, Mapo-Gu Sangsoo Dong 72-1 Seoul, Korea 121-791View Profile Authors Info & Claims CIKM '98: Proceedings of the seventh international conference on Information and knowledge managementNovember 1998 Pages 167–174https://doi.org/10.1145/288627.288654Published:01 November 1998Publication History 9citation413DownloadsMetricsTotal Citations9Total Downloads413Last 12 Months16Last 6 weeks5 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Numerical evaluation of ECT impedance signal due to minute cracks (1997)

This paper describes an experimental and analytical study on minute crack inspection with eddy current testing (ECT). Measurement and simulation using a 3D FEM program are applied for the evaluation of the detecting signal with a minute crack in a test piece. Parameters such as mesh division, ICCG convergence criteria, etc. are evaluated to achieve high accuracy in numerical calculation. The simulation results agreed with experimental ones.
Templated amplification of a naphthalenediimide-based receptor from a donor–acceptor dynamic combinatorial library in water (2008)

We report a dynamic combinatorial library that, upon binding of an electronically-complementary guest, produces in high yield a tetrameric receptor with flat hydrophobic, electron-deficient surfaces and flexible, water-soluble disulfide-containing linkers; analysis of the dependence of library composition on template concentration gives insight into the binding behaviours of the species involved.
Tourism: who needs it? (1996)

Is tourism economically beneficial? If so, who benefits? How much of the money generated through tourism can be channeled into other projects so desperately needed by the community without harming the local tour market? Will tourism continue to grow forever, or is there an end in sight? The authors discuss how tourism will change in approaching the next century: and how people will change if tourism is to remain such an important economic facto
Getting to Zero: Evidence‐based healthcare risk management is key (2012)

In this article we call for a new approach to patient safety improvement, one based on the emerging field of evidence-based healthcare risk management (EBHRM). We explore EBHRM in the broader context of the evidence-based healthcare movement, assess the benefits and challenges that might arise in adopting an evidence-based approach, and make recommendations for meeting those challenges and realizing the benefits of a more scientific approach.
The use of thiobarbituric acid as a measure of fat oxidation (1954)

Summary An evaluation of thiobarbituric acid (TBA) as an agent for the measurement of fat oxidation was made by the application of several empirical procedures to animal and vegetable fats. An extraction procedure was used for removing the products of oxidation. The reaction with TBA was conducted in a boiling water bath to produce a red color, which was then estimated spectrophotometrically. Fats stored at −20, 0, 72, and 100°F. (−29, −18, 22, and 38°C.) and fats oxidized by the active oxygen method (A.O.M.) and by ultraviolet irradiation were examined. It was found that the TBA test might be of value in following the course of oxidation of cottonseed oil and soybean oil in the A.O.M. apparatus. Higher TBA values were obtained for soybean oil than cottonseed oil at comparable peroxide values. This is of interest because of the greater tendency of soybean oil to develop oxidized flavors. The volatile reaction products of oxidation were collected in toluene, and a comparison of the TBA values at comparable peroxide values of lard, cottonseed and soybean oils showed that the soybean oil volatiles developed the greatest intensity of color.
Reversible Pebble Games for Reducing Qubits in Hierarchical Quantum Circuit Synthesis (2019)

Hierarchical reversible logic synthesis can find quantum circuits for large combinational functions. The price for a better scalability compared to functional synthesis approaches is the requirement for many additional qubits to store temporary results of the hierarchical input representation. However, implementing a quantum circuit with large number of qubits is a major hurdle. In this paper, we demonstrate and establish how reversible pebble games can be used to reduce the number of stored temporary results, thereby reducing the qubit count. Our proposed algorithm can be constrained with number of qubits, which is aimed to meet. Experimental studies show that the qubit count can be significantly reduced (by up to 63.2%) compared to the state-of-the-art algorithms, at the cost of additional gate count.
A putative receptor for neurosteroids on the GABAA receptor complex: the pharmacological properties and therapeutic potential of epalons. (1995)

A critical mass of evidence now supports the existence of a novel class of neuroactive steroids. These steroids are devoid of any known steroid hormone activity and have high specificity for the gamma-aminobutyric acidA receptor complex (GRC), which is a ligand-gated chloride channel that mediates the inhibitory action of the neurotransmitter gamma-aminobutyric acid (GABA). The action of these steroids at the GRC is to allosterically potentiate the effect of GABA on chloride channel conductance through a unique site on the GRC. These neuroactive steroids have been termed the epalons, a shortened form of epiallopregnanolone, an endogenous metabolite of progesterone with potent actions at the GRC. Putative epalon receptors may be unique sites on the GRC that mediate the effects of epalons on GABA-gated channel function. The pharmacological profile of the epalons is consistent with those of other positive modulators of GABA action (e.g., the clinically useful benzodiazepines (BZs) and barbiturates). These neuroactive steroids have anxiolytic, anticonvulsant, and sedative-hypnotic properties. Based upon some of the unique characteristics of the epalons relative to barbiturates and the BZs, it is plausible that the epalons can be developed into a novel class of therapeutic agents for the treatment of anxiety, epilepsy, and insomnia.