gebhart/patrepeval huggingface dataset:
[Changes in the fatty-acid spectrum of epidermal structures in various age group patients with psoriasis]. (2010)

The paper depicts changes in the epidermal fatty-acid spectrum in patients with psoriasis progressing to the stage of dermatosis in various age groups (18-40 and 41-60 years). The parameters studied in healthy individuals showed age-related differences in the pool of saturated and unsaturated fatty acids (SCFA). Heterodirectional changes in the epidermal levels of saturated, polyenic, and monoenic fatty acids were recorded in the lesion foci and visually healthy skin of patients with psoriasis depending on age.
A Fast Hardware Implementation of RSA Algorithm (2003)

The paper has reported a successful DSP hardware implementation of RSA in a PC PCI board using the latest commercial TMS320C6201 fix-point DSP EVM and latest TI code composer studio DSP software development tools and a strong prime concept is used in key generation.
Rapidly Adjustable Non-intrusive Online Monitoring for Multi-core Systems (2017)

This paper presents an approach for rapidly adjustable embedded trace online monitoring of multi-core systems, called RETOM. Today, most commercial multi-core SoCs provide accurate runtime information through an embedded trace unit without affecting program execution. Available debugging solutions can use it to reconstruct the run offline, but usually for up to a few seconds only. RETOM employs a novel online reconstruction technique that makes the program run available outside the SoC and allows for evaluating a specification formulated in the stream-based specification language TeSSLa in real time. The necessary computing performance is provided by an FPGA-based event processing system. In contrast to other hardware-based runtime verification techniques, changing the specification requires no circuit synthesis and thus seconds rather than minutes or hours. Therefore, iterated testing and property adjustment during development and debugging becomes feasible while preserving the option of arbitrarily extending observation time, which may be necessary to detect rarely occurring errors. Experiments show the feasibility of the approach.
PEROXIDIC INTERMEDIATES IN INDOLE–SINGLET OXYGEN REACTIONS: MECHANISM OF THE C<sub>2</sub>—C<sub>3</sub> RING CLEAVAGE OF TRYPTOPHOL* (1978)

Abstract— Photosensitized oxygenation of tryptophol (1) at –70°C gives the corresponding 3‐hydroperoxyindoline 2 as a primary product. Chemical and photochemical behaviors of the hydroperoxide (2) have been investigated. Photolysis and redox reactions of 2 with ferrous ion give a C 2 —C 3 ring cleavage product 5 together with 3‐hydroxyindoline 3. A mechanism involving O—O homolysis of the hydroperoxide has been proposed. Thermal decomposition of 2 leading to 3 and 5 is also suggested to proceed via the O—O homolysis.
Preparation of High-T<sub>c</sub> Tl-Ba-Ca-Cu-O Superconductors (1988)

Bulk superconductors of the Tl-Ba-Ca-Cu-O system have been investigated to clarify their superconducting properties; these were found to be significantly sensitive to the sintering temperature and the composition of the oxides. Zero-resistance was achieved at 118 K for Tl 2 Ba 2 Ca 2 Cu 3 O x sintered at 880°C for 1 h in O 2 . In addition, an ac susceptibility result also supports its superconductivity with high critical temperature.
Characterization of Bacteriophage gh-1 for <i>Pseudomonas putida</i> (1966)

Lee, Lucy F. (Michigan State University, East Lansing), and J. A. Boezi. Characterization of bacteriophage gh-1 for Pseudomonas putida. J. Bacteriol. 92:1821-1827. 1966.-Bacteriophage gh-1 of Pseudomonas putida A.3.12 was isolated and purified by differential centrifugation and diethylaminoethyl (DEAE) cellulose chromatography. An electron micrograph of the phage stained with uranyl acetate revealed a regular hexagonal outline about 50 mmu across with a short wedge-shaped tail attached at one corner of the head. The phage formed 10% as many plaques on P. putida C1S as on P. putida A.3.12, the organism used in the isolation procedure. No plaques were formed on P. fluorescens (ATCC 9712) or P. aeruginosa. The latent period of the infectious cycle was 21 min, and the average burst size was 103. The nucleic acid component of gh-1 is double-stranded deoxyribonucleic acid (DNA), with a base composition of 57.0% guanine plus cytosine (G + C) as determined by chemical analysis. The per cent G + C of P. putida A.3.12 DNA measured in a similar manner was 63.7%. The buoyant density of phage gh-1 measured by cesium chloride equilibrium centrifugation was 1.45 g/cm(3), whereas that of gh-1 DNA, heat-denatured gh-1 DNA, and P. putida A.3.12 DNA was 1.716, 1.730, and 1.722 g/cm(3), respectively. The per cent G + C of gh-1 DNA and P. putida A.3.12 DNA calculated from the buoyant densities was 57.1 and 63.3%, respectively. The sedimentation coefficients, S(50) (20,w), of gh-1 and the phenol-extracted gh-1 DNA, measured by the boundary sedimentation velocity method, were 460 and 18.9, respectively. The molecular weight of phenol-extracted gh-1 DNA, calculated by use of the equation of Burgi and Hershey, is 6 x 10(6).
Complex B<sub>1</sub> mapping and electrical properties imaging of the human brain using a 16‐channel transceiver coil at 7T (2012)

The electric properties of biological tissue provide important diagnostic information within radio and microwave frequencies, and also play an important role in specific absorption rate calculation which is a major safety concern at ultrahigh field. The recently proposed electrical properties tomography (EPT) technique aims to reconstruct electric properties in biological tissues based on B1 measurement. However, for individual coil element in multichannel transceiver coil which is increasingly utilized at ultrahigh field, current B1-mapping techniques could not provide adequate information (magnitude and absolute phase) of complex transmit and receive B1 which are essential for electrical properties tomography, electric field, and quantitative specific absorption rate assessment. In this study, using a 16-channel transceiver coil at 7T, based on hybrid B1-mapping techniques within the human brain, a complex B1-mapping method has been developed, and in vivo electric properties imaging of the human brain has been demonstrated by applying a logarithm-based inverse algorithm. Computer simulation studies as well as phantom and human experiments have been conducted at 7T. The average bias and standard deviation for reconstructed conductivity in vivo were 28% and 67%, and 10% and 43% for relative permittivity, respectively. The present results suggest the feasibility and reliability of proposed complex B1-mapping technique and electric properties reconstruction method.
Outbreak of severe acute respiratory syndrome in Hong Kong Special Administrative Region: case report (2003)

The rapidity of the spread of the disease and the morbidity indicate that the agent responsible is highly infectious and virulent. Strict infection control measures for droplet and contact transmission by healthcare workers, a vigilant healthcare profession, and public education are essential for disease prevention.
A 26 W 97%-Efficiency Fast-Settling Dimmable LED Driver With Dual-nMOS-Sensing Based Glitch-Tolerant Synchronous Current Control for High-Brightness Solid-State Lighting Applications (2015)

This paper presents an integrated buck-type dimmable synchronous LED driver for high-brightness solid-state lighting applications. A glitch-tolerant synchronous current control (GT-SCC) scheme is proposed to regulate the average LED current. The GT-SCC enables fast settling time of the LED current upon start-up or PWM dimming condition, and provides reliable operation under high dV/dt slewing during switching transitions of the LED driver. The proposed LED driver consists of a high-speed low-power HV synchronous gate driver to enable on-chip synchronous rectification with a dual-nMOS power train under different input voltages for the conduction power loss reduction. Two on-chip senseFET peak and valley current sensors are also developed to offer low-power and reliable current sensing under high input voltages. Implemented in a 0.35 μm 50 V CMOS process, the proposed LED driver supports a wide input range from 5 V to 45 V, operates up to 4 MHz with a small-value inductor of 8.2 μH, handles a high PWM dimming frequency of 20 kHz with a wide duty-ratio range from 0.1 to 1, and delivers an average LED current of 700 mA for driving up to 12 series-connected HB-LEDs (with the maximum output power of 26 W). The proposed LED driver achieves a peak power efficiency of 97.2% and the current deviation ≤ ±3.3% of the average LED current under different conditions. The worst-case settling time achieves 3.2 μs that is at least 2.7 times improvement over state-of-the-art counterparts.
Basic Cardiac Life Support Providers Checking the Carotid Pulse: Performance, Degree of Conviction, and Influencing Factors (2004)

These results question the routine use of the carotid pulse check during cardiopulmonary resuscitation, including for health care providers.
The NMDA and AMPA/KA Receptors are Involved in Glutamate-Induced Alterations of Occludin Expression and Phosphorylation in Brain Endothelial Cells (2007)

Glutamate levels increase dramatically in cerebral ischemia and stroke. This may lead to opening of the blood-brain barrier (BBB) and induce further brain damage. Because endothelial tight junctions are critical elements of the BBB integrity, the aim of this study was to investigate the mechanisms of glutamate-induced alterations of the tight-junction protein occludin in cultured brain microvascular endothelial cells (BMECs). Transient exposure to glutamate resulted in cellular redistribution of occludin, followed by a decrease in the total level of this protein and diminished barrier function of BMECs. Inhibition of the N-methyl-D-aspartate (NMDA) or alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate (AMPA/KA) receptors attenuated glutamate-induced changes in occludin redistribution but not in the total protein levels. Treatment with glutamate also increased tyrosine phosphorylation and decreased threonine phosphorylation of occludin. Inhibition of the NMDA receptors by MK-801 partially protected against glutamate-induced elevation of occludin tyrosine phosphorylation. In addition, pretreatment with MK-801-attenuated glutamate-mediated disruption of endothelial barrier function. Blocking of the AMPA/KA receptors by 6,7-dinitroquinoxaline-2.3-dione (DNQX) protected against hypophosphorylation of threonine residues of occludin; however, it did not affect disruption of endothelial integrity. These findings indicate the opposite effects of the NMDA and AMPA/KA receptors on occludin phosphorylation and disruption of the BBB functions.
Supramolecular Polymer Networks Made by Solvent-Free Copolymerization of a Liquid 2-Ureido-4[1<i>H</i>]-pyrimidinone Methacrylamide (2015)

Supramolecular polymer networks based on polyacrylates with hydrogen bonding 2-ureido-4[1H]-pyrimidinone (UPy) side chains are of considerable interest due to the stimuli-responsive nature imparted by the reversible cross-links formed by dimerized UPy groups. Previously reported UPy-containing acrylic monomers are solid and show limited miscibility with comonomers, and this has stifled their (co)polymerization in bulk. We here report the synthesis of a liquid 2-ureido-4[1H]-pyrimidinone methacrylamide (UPy-OPG-MAA), which was made by connecting the UPy motif and methacrylamide (MAA) via an amine-terminated oligo(propylene glycol) (OPG) linker. The new monomer was miscible with conventional methacrylates. This permitted the photoinitiated free-radical bulk copolymerization with hexyl methacrylate (HMA) to afford a series of copolymers (poly(UPy-OPG-MAA-co-HMA)) in which the UPy-OPG-MAA content was varied between 0 and 20 mol %. The investigation of the mechanical properties of these copolymers by dynamic mechanical analysis and adhesion tests revealed that the introduction of the UPy groups leads to an increase of the stiffness in the glassy state, the formation of a rubbery plateau above the glass transition temperature, and a significant increase of the adhesive strength. Joints bonded with poly(UPy-OPG-MAA-co-HMA) could be debonded on demand using light or heat.
Improved Current Sharing Performance by Dynamic Droop Scaling Technique in Multiple Power Systems (2007)

This paper presents a novel dynamic droop scaling (DDS) technique for paralleled power modules. The major concern is the uniform current distribution of each module in multiple power systems. The droop method relies on the slope characteristic of load regulation to achieve current sharing accuracy. Owing to the trade-off between error percentages of current sharing and output voltage variation, conventional droop technique can't provide good load regulation and current balance at the same time. However, the proposed DDS technique can break through the limitation of the conventional droop method by the implementation of dual current sensing loops. The dual current sensing loops not only increase the droop gain but also compensate the extra output dropout voltage automatically according to the steeper slope value of the novel method. Simulation results verify the error percentage of current sharing accuracy can be improved from 42.5% to 8.2% by DDS technique.
Understanding the Mechanism of Direct Activation of AMP-Kinase: Toward a Fine Allosteric Tuning of the Kinase Activity (2019)

Mammalian AMP-activated protein kinase (AMPK) is a Ser/Thr protein kinase with a key role as a sensor in cellular energy homeostasis. It has a major role in numerous metabolic disorders, such as type 2 diabetes, obesity, and cancer, and hence it has gained progressive interest as a potential therapeutic target. AMPK is a heterotrimeric enzyme composed by an α-catalytic subunit and two regulatory subunits, β and γ. It is regulated by several mechanisms, including indirect activators such as metformin and direct activators such as compound A-769662. The crystal structure of AMPK bound to A-769662 has been recently reported, suggesting a hypothetical allosteric mechanism of AMPK activation assisted by phosphorylated Ser108 at the β-subunit. Here, we have studied the direct activation mechanism of A-769662 by means of molecular dynamics simulations, suggesting that the activator may act as a glue, coupling the dynamical motion of the β-subunit and the N-terminal domain of the α-subunit, and assisting the preorganization of the ATP-binding site. This is achieved through the formation of an allosteric network that connects the activator and ATP-binding sites, particularly through key interactions formed between αAsp88 and βArg83 and between βpSer108 and αLys29. Overall, these studies shed light into key mechanistic determinants of the allosteric regulation of this cellular energy sensor, and pave the way for the fine-tuning of the rational design of direct activators of this cellular energy sensor.
Sorción y solubilidad de materiales formulados con resina (2003)

espanolEl objetivo de este estudio fue determinar la sorcion y solubilidad de cuatro resinas compuestas: Tetric Ceram (Vivadent), Ecusit (DMG), Degufill (Degussa) y Z-250 (3M-Espe); y dos resinas modificadas con poliacido: Luxat (DMG) e lonosit (DMG). Cinco especimenes circulares (15 mm x 0.85 mm) de cada material fueron preparados y pulidos con discos de carburo de silicio. Los especimenes fueron desecados en una estufa a 37o C hasta que se registro un peso constante (mo) y, posteriormente, se introdujeron en agua destilada a 37o C (m1). Una vez estabilizado su peso fueron desecados nuevamente, colocados en una campana al vacio (60oC, 24 h) y pesados por ultima vez (m2). El calculo de la sorcion (A) y solubilidad (S) se realizo mediante expresiones matematicas interrelacionadas: A = m1-m2/V; S = mo - m2 / V. Los tests de ANOVA y Student Newman Keuls mostraron diferencias en la sorcion y solubilidad segun el material estudiado (p EnglishThe aim of this study was to determine the sorption and solubility of four resin composites: Tetric Ceram (Vivadent), Ecusit (DMG), Degufill (Degussa) and Z-250 (3M-Espe); and two polyacid-modified resins: Luxat (DMG) and lonosit (DMG). Five discs (15 mm x 0.85 mm) of each material were prepared and ground wet to remove poorly polymerized suface layers. Discs were conditioned in a desiccator (37o C) until a constant weight was achieved using an analytic balance (mo); immersed in distilled water 37o C (m1) and finally into a vacuum oven (60o C, 24 h) and reweighted (m2). Sorption (A) and solubility (S) were calculated: A = m1 - m2 / V; S = mo - m2 / V. ANOVA and SNK tests showed statistical differences among the studied materials. lonosit showed the highest sorption and Tetric Ceram and Ecusit the lowest. Luxat presented higher sorption than Degufill, but both materials showed similar sorption values compared with Z-250. The higher solubility was obtained by lonosit. No statistical differences were found among resin composites and Luxat
Microbial pathogens and apoptotic anticancer therapy (2000)

In spite of tremendous efforts to control cancer, the mortality associated with this disease has been increasing in developed countries in the recent decades. Inadequate efficiency of existing therapeutic regimens and the rise of multi-drug resistant cancer cells are the main factors which require a broadening of investigations into novel anticancer strategies. Enhancement of apoptosis in tumours has been suggested recently as a new anticancer strategy. It targets the disruption of equilibrium between cell proliferation and cell death in tumours and suggests to restore it through the use of pharmacological agents or genetic approaches. Apoptotic therapy has attracted many groups of investigators and several companies have entered the race to develop the first generation of apoptotic anticancer agents. The review discusses the role that pathogenic microorganisms may have as the source of agents for apoptotic therapy.
Evolución de la calidad del agua en el río Segura. El sistema tradicional de riego y las obras de aprovechamiento (1999)

La calidad del rio Segura esta seriamente danada como consecuencia
de la gran cantidad de vertidos, con escasa o nula depuracion, que va
recogiendo desde el Azud de Ojos hasta Guardamar. Las vegas media y
baja son las que, en mayor medida, sufren los efectos de la contaminacion.
El sistema tradicional de riego en ambas vegas se basa en la reutilizacion
de las aguas sobrantes de los riegos de las zonas mas altas. Dicho
sistema esta formado por un entramado de acequias y azarbes, que
toman el agua del rio a traves de los azudes, distribuyendola por las
acequias que la transportan hasta los campos. El agua sobrante del riego
es recogida en los azarbes, pudiendo ser asi reutilizada en campos situados
en zonas mas bajas.
Las ampliaciones de la superficie de regadio tradicional asi como las
dotaciones fueron establecidas en el Decreto de 25 de abril de 1953
sobre la ordenacion de los riegos del rio Segura. Posteriormente, como
consecuencia del Trasvase Tajo-Segura, la superficie de regadio aumento
considerablemente, viendose cortado el rio en el Azud de Ojos, para
poder abastecer todos los regadios creados, quedando infradotado todo
el regadio tradicional existente. La solucion que se viene dando a toda
esta problematica son los llamados riegos de socorro, para salvar los
cultivos arboreos, con lo que de una manera inexplicable, hemos desregulado
todo el regadio tradicional, pero lo mas importante, privando de
sus derechos a las tierras a las que pertenece el agua, en beneficio de
usurpaciones ilegitimas. Asi que resulta un absurdo, oir hablar de que se
conceden caudales ecologicos que circulan por el rio, cuando de lo que
hay que hablar, y obtener, es que por este discurran las aguas que por
derecho constituyen la dotacion de la huerta tradicional del rio, y que
no tiene porque estar sometida a riegos de socorro esporadicamente
otorgados.
En cuanto a la contaminacion, se debe conseguir que las aguas que
se devuelvan al rio esten totalmente depuradas, y las que proceden del
drenaje de las ampliaciones de regadio de la margen derecha, se eliminen
directamente al mar mediante un colector que las recoja, evitando
su mezcla con las que discurran depuradas por el cauce del rio.
Bioinformatics analysis reveals transcriptome and microRNA signatures and drug repositioning targets for IBD and other autoimmune diseases (2012)

This study presents a clinically relevant gene-level portrait of IBD subtypes and their connectivity to autoimmune diseases. The study identified candidates for repositioning of existing drugs to manage IBD. Integration of mice and human data point to an altered B-cell response as a cause for upregulation of genes in IBD involved in other aspects of immune defense such as interferon-inducible responses.
Robustness issues of 2-sliding mode control (2004)

The sliding mode control approach is based on keeping exactly a properly chosen constraint by means of high frequency switching of the control. The high frequency control switching leads to the so-called chattering effect which is exhibited by high frequency vibration of the controlled plant and can be dangerous in some applications. It is shown in this section that the arising higher-order sliding mode is never stable, but the instability is local and not crucial if the actuator is fast and stable. The case of a linear autonomous control system is considered. It is shown by the method of description functions that fast stable actuators cause oscillations in a small vicinity of the 2-sliding manifold. Correspondent simulation results are presented.
596. The reaction of “Paludrine”(proguanil) with ethyl acetoacetate (1951)

G. P. Fraser and W. O. Kermack, J. Chem. Soc., 1951, 2682 DOI: 10.1039/JR9510002682
Comprehensive Evaluation of Key Management Scheme in Wireless Sensor Networks (2006)

To the crucial point of how choose effective key management scheme to realize security of wireless sensor network, this paper presents a comprehensive evaluation approach on key management. This method constructs model of comprehensive evaluation with metrics worked out on key management. Combined with fuzzy method and hierarchical analysis method, the subjective factors on evaluation functions of key management scheme are reduced to minimum. The accuracy and believability of the evaluation results are effectively improved. It ensures to choose effective key management scheme according to the requirement. Finally, the effectiveness of this measurement is verified by an experiment.
Low-resolution mapping of the effective attenuation coefficient of the human head: a multidistance approach applied to high-density optical recordings (2017)

Near infrared (NIR) light has been widely used for measuring changes in hemoglobin concentration in the human brain (functional NIR spectroscopy, fNIRS). fNIRS is based on the differential measurement and estimation of absorption perturbations, which, in turn, are based on correctly estimating the absolute parameters of light propagation. To do so, it is essential to accurately characterize the baseline optical properties of tissue (absorption and reduced scattering coefficients). However, because of the diffusive properties of the medium, separate determination of absorption and scattering across the head is challenging. The effective attenuation coefficient (EAC), which is proportional to the geometric mean of absorption and reduced scattering coefficients, can be estimated in a simpler fashion by multidistance light decay measurements. EAC mapping could be of interest for the scientific community because of its absolute information content, and because light propagation is governed by the EAC for source-detector distances exceeding 1 cm, which sense depths extending beyond the scalp and skull layers. Here, we report an EAC mapping procedure that can be applied to standard fNIRS recordings, yielding topographic maps with 2- to 3-cm resolution. Application to human data indicates the importance of venous sinuses in determining regional EAC variations, a factor often overlooked.