gebhart/patrepeval huggingface dataset:
A Rapid Assay of Cytosine Arabinoside Uptake and Metabolism by Acute Myeloid Leukaemic Cells Using a Bioluminescent Bacterial Biosensor. (2007)

Abstract We have already reported the construction and evaluation of a self-bioluminescent reporter strain of E. coli with high sensititivity to the nucleoside analogue cytosine arabinoside (Ara-C) the mainstay of treatment in patients with Acute Myeloid Leukaemia (Blood, 106 (11), Abstr. 2473; 695a). This rapid assay, which uses a bioluminescent biosensor to measure intracellular levels of Ara-C and its active metabolite Ara-CTP, has been utilised in leukaemic cell lines KG1a (FAB type M0) which is sensitive to Ara-C and THP-1 (FAB type M5) which is partially insensitive to Ara-C due to over expression of cytidine deaminase (cdd). It has also been used in primary cultures of AML cells from six patients with M0 (n=1), M2 (n=2), M3 (n=1) and M4 (n=2). Intracellular concentrations of Ara-C as low as 0.05 μM can be detected by an increase in light output from the bacterial biosensor. The technology is suitable for the quantitation of response to clinical Ara-C doses (between 25–100μM) in less than 8 hours. Results from the KG1a cell line with known sensitivity to Ara-C showed correlation between the rapid assay and a 3 day cytotoxicity test of Ara-C sensitivity. Preliminary tests with the six clinical marrow samples showed 100% concordance with clinical outcome within eight hours of commencing the assay (vide infra: Table 1). In newly diagnosed AML patients, only 70% are sensitive to Ara-C therapy. Interestingly, in our hands, the M3 patient was Ara-C insensitive despite the fact that, most commonly, M3 patients do not express p-glycoprotein and therefore do not require Ara-C. Our small cohort of patients were disproportionately insensitive to Ara-C and therefore had a poor outcome overall. This assay system is potentially suitable for prescreening AML samples prior to commencement of Ara-C containing chemotherapy regimens. It may also give information on relative Ara-C sensitivity thus permitting dose adjustment and prevention of unnecessary toxicity to other organs. The assay could be repeated at relapse to document clonal evolution and decide whether Ara-C can be used to achieve a second remission. Work is currently underway with an industrial partner to look at commercialisation of this assay. TABLE 1: Correlation between light output and clinical response in six patients with primary AML Patient Diagnosis Clinical Outcome Differential Light Output: cytotoxicity test Bioluminescent Assay: Ara-C sensitivity 1 M0 No response 5% no 2 M2 No Response 84% no 3 M2 No Response 79% no 4 M3 Remission Death 91% no 5 M4 Complete Response 99% yes 6 M4 No Response 62% no
A Software Implementation of the IEEE 754R Decimal Floating-Point Arithmetic Using the Binary Encoding Format (2008)

The IEEE Standard 754-1985 for binary floating-point arithmetic [19] was revised [20], and an important addition is the definition of decimal floating-point arithmetic [8], [24]. This is intended mainly to provide a robust reliable framework for financial applications that are often subject to legal requirements concerning rounding and precision of the results, because the binary floating-point arithmetic may introduce small but unacceptable errors. Using binary floating-point calculations to emulate decimal calculations in order to correct this issue has led to the existence of numerous proprietary software packages, each with its own characteristics and capabilities. The IEEE 754R decimal arithmetic should unify the ways decimal floating-point calculations are carried out on various platforms. New algorithms and properties are presented in this paper, which are used in a software implementation of the IEEE 754R decimal floating-point arithmetic, with emphasis on using binary operations efficiently. The focus is on rounding techniques for decimal values stored in binary format, but algorithms are outlined for the more important or interesting operations of addition, multiplication, and division, including the case of nonhomogeneous operands, as well as conversions between binary and decimal floating-point formats. Performance results are included for a wider range of operations, showing promise that our approach is viable for applications that require decimal floating-point calculations. This paper extends an earlier publication [6].
Reinstalación del Archivo Rubén Darío (2010)

El Archivo Ruben Dario recoge los documentos facilitados al Ministerio de Educacion en 1956 por Dona Francisca Sanchez, companera del poeta a partir del ano 1899, ano desde el cual conservo todos sus documentos hasta su muerte; y que fueron depositados posteriormente en la Facultad de Filologia de la Universidad Complutense. Su ubicacion definitiva es en la Biblioteca Historica U.C.M., donde se lleva a cabo el proyecto de reinstalacion para su optima conservacion a largo plazo. Parte de este trabajo fue realizado por las autoras durante la campana de verano, bajo convenio de colaboracion entre la Escuela Superior de Conservacion y Restauracion de Bienes Culturales de Madrid y la Biblioteca Historica de la UCM, siendo tutoras de los trabajos Pilar Puerto y Alejandra Rico del departamento de Conservacion y Restauracion de la citada biblioteca.
Comparative Activities of the Triterpene Saponin Maesabalide III and Liposomal Amphotericin B (AmBisome) against<i>Leishmania donovani</i>in Hamsters (2004)

Maesabalide III (MB-III), an oleane triterpene saponin isolated from the Vietnamese plant Maesa balansae, is a new antileishmanial lead compound whose activity against Leishmania donovani (MHOM/ET/67/L82) in groups of five golden hamsters was evaluated after administration of a single subcutaneous dose on either day 1 (prophylactic treatment) or day 28 (curative treatment) after infection. Liposomal amphotericin B (AmBisome), administered intravenously at 5 mg/kg of body weight, was used as the reference drug. Amastigote burdens in liver, spleen, and bone marrow were determined either 7 days (early effects) or 56 days (late effects) after treatment. Prophylactic administration of MB-III at 0.2 mg/kg reduced liver amastigote burdens by 99.8 and 83% within 7 and 56 days after treatment, respectively. In the latter group, however, all animals became ill and some died. Both MB-III at 0.8 mg/kg and liposomal amphotericin B were 100% effective against liver stages, but clearance from the spleen and bone marrow was not achieved. Curative administration of MB-III at 0.2 and 0.4 mg/kg was not protective, as no survivors were left at the termination of the experiment on day 84. Despite the high level of reduction of the liver amastigote burden after treatment with MB-III at 0.8 mg/kg (94.2%) or liposomal amphotericin B (99.4%), clinical protection could not be obtained in either group, with two deaths occurring and the residual liver burdens persisting. It is concluded that administration of a single dose of MB-III at 0.8 mg/kg has efficacy potential comparable to that of a single dose of liposomal amphotericin B at 5 mg/kg and is therefore considered a promising new antileishmanial lead compound. However, multiple-dose pharmacological, toxicological, and pharmacokinetic studies are still needed before it can become a valid drug candidate for development.
A survey of Illinois community-college chief academic officers to identify the administrative issues to be considered when delivering online instruction (2003)

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Heat Shock Protein Inhibition in Sickle Cell Disease: A Novel Approach to Attenuating the Inflammatory Response?. (2007)

Abstract Sickle cell disease (SCD) is a genetic disorder resulting from a single amino acid substitution on the β globin chain. It is well established that inflammation is a key component of the protean manifestations and complications of SCD. The heat shock proteins are a group of evolutionarily conserved proteins that are up-regulated in response to cellular stress. However, it has been recognized that an exaggerated response may be detrimental rather than beneficial. In our exploratory study, we look at effects of Hsp90 inhibition in mononuclear cells from controls and patients with SCD after stimulation with lipopolysaccharide (LPS). Whole blood was drawn from 2 African-American controls and 6 patients with SCD in steady state (3 on hydroxyurea (HU) and 3 off HU). Mononuclear cells were separated using Ficoll Hypaque density gradient centrifugation and were washed and suspended in RPMI containing penicillin, streptomycin, and heat inactivated autologous serum. Dilution of the final cell suspension was adjusted to achieve a mononuclear cell count of 400,000/0.5 ml. Each subject’s cell suspension was divided into 4 aliquots: control (V), cells stimulated with LPS (L), and cells treated with heat shock protein inhibitors 17-AAG (A) and Radiciol (R) followed by stimulation with LPS. Subsequently cell suspensions were incubated for 24 hours in a CO2 incubator at 37°C. Supernatants were then extracted and frozen at −70°C. Multiplex cytokine bead assay was performed. No significant change in response to LPS challenge or Hsp90 inhibition was observed for IFNγ, IL-2, IL-4, and IL-5. TNFα and IL-10 showed significant increases with LPS challenge, which could be almost completely inhibited by preincubation with 17-AAG and Radiciol. The magnitude of the TNFα and IL-10 responses to LPS challenge in SCD patients was significantly greater than controls. This held true for patients on and off HU. While there seemed to be a trend towards a more blunted response of TNFα to LPS challenge in HU treated patients, the numbers in this exploratory study are too small to allow statistical comparisons. These data confirm the previous observations that mononuclear cells in SCD are in an activated state and respond to LPS challenge in a more pronounced manner. The increase in IL-10 is more likely the result of a counteractive response to TNFα elevations. Significant observation of this preliminary study is that the inhibition of Hsp90 blunts the TNFα response to LPS challenge and may potentially offer a mechanism of modulation of inflammation in SCD. Determinations of other inflammatory cytokines are currently underway. Figure Figure
dbCAN: a web resource for automated carbohydrate-active enzyme annotation (2012)

Carbohydrate-active enzymes (CAZymes) are very important to the biotech industry, particularly the emerging biofuel industry because CAZymes are responsible for the synthesis, degradation and modification of all the carbohydrates on Earth. We have developed a web resource, dbCAN (http://csbl.bmb.uga.edu/dbCAN/annotate.php), to provide a capability for automated CAZyme signature domain-based annotation for any given protein data set (e.g. proteins from a newly sequenced genome) submitted to our server. To accomplish this, we have explicitly defined a signature domain for every CAZyme family, derived based on the CDD (conserved domain database) search and literature curation. We have also constructed a hidden Markov model to represent the signature domain of each CAZyme family. These CAZyme family-specific HMMs are our key contribution and the foundation for the automated CAZyme annotation.
Analysing Driver's Attention Level using Computer Vision (2008)

This paper presents a system for evaluating the attention level of a driver using computer vision. The system detects head movements, facial expressions and the presence of visual cues that are known to reflect the user's level of alertness. The fusion of these data allows our system to detect both aspects of inattention (drowsiness and distraction), improving the reliability of the monitoring over previous approaches mainly based on detecting only one (drowsiness). Head movements are estimated by robustly tracking a 3D face model with RANSAC and POSIT methods. The 3D model is automatically initialized. Facial expressions are recognized with a model-based method, where different expressions are represented by a set of samples in a low-dimensional manifold in the space of deformations. The system is able to work with different drivers without specific training. The approach has been tested on video sequences recorded in a driving simulator and in real driving situations. The methods are computationally efficient and the system is able to run in real-time.
Percutaneous Radiofrequency Ablation of Hepatocellular Carcinoma: Fusion Imaging Guidance for Management of Lesions With Poor Conspicuity at Conventional Sonography (2012)

Fusion imaging-guided percutaneous RFA is effective in the management of HCC that has poor ultrasound conspicuity.
The Impact of HLA Mismatches on the Survival of First Cadaveric Kidney Transplants (1994)

Under ideal circumstances, a policy of maximal matching of cadaveric renal transplants would increase five-year graft survival by a comparatively small 4.4 percentage points, but the actual benefit is likely to be smaller.
Overhead Installation of Injection-Type Adhesive Anchors (2016)

An evaluation of two available methods and
The use of mobile contact list applications and a context-oriented framework to support their design (2009)

Contact lists are one of the most frequently used applications on mobile devices. They are used not only as contact detail repositories, but also as temporary information storage for unrelated items, such as PINs or passwords. Users are reluctant to delete or remove contacts from their repositories. As such, these become increasingly large, sometimes measuring several hundred entries. In this paper we present our findings from early investigations into the use of mobile Contact Lists. We also propose a context oriented design framework to aid the speed and efficacy of the information seeking and retrieval process during the use of the Contact List application.
Adoptive Immunotherapy of Cancer with Polyclonal Hyperexpanded CD4 and CD8 T Cells Derived from Tumor-Draining Lymph Nodes (2004)

s for the 19th Annual Scientific Meeting of the International Society for Biological Therapy of Cancer, San Francisco, California, November 4-7, 2004: Adoptive Immunotherapy
Human Body Dimensions Extraction from 3D Scan Data (2010)

3D body dimensions extracting is the basis that 3D body scanner evolve in clothing applications. In this paper, the body point cloud is acquired by 3D body scanner developed by our team. The initial point cloud is processed for reconstructed body triangular mesh model which is used to extract the body dimensions. The methods of processing the point cloud and constructed body model are simply discussed and the detail discussion can be found in my paper that is being published. In order to calculate the body dimensions, the reference points are identified according to the characteristic of the feature contours. Then the body dimensions, including length size and girth size, are extracted. By measuring 10 feature sizes of different bodies, the factors that affect the dimensional accuracy is analysed. The result shows the method is effective to extracting the body dimensions.
Efficient Simulation from the Multivariate Normal and Student-t Distributions Subject to Linear Constraints and the Evaluation of Constraint Probabilities (1991)

The construction and implementation of a Gibbs sampler for efficient simulation from the truncated multivariate normal and Student-t distributions is described. It is shown how the accuracy and convergence of integrals based on the Gibbs sample may be constructed, and how an estimate of the probability of the constraint set under the unrestricted distribution may be produced. Keywords: Bayesian inference; Gibbs sampler; Monte Carlo; multiple integration; truncated normal This paper was prepared for a presentation at the meeting Computing Science and Statistics: the Twenty-Third Symposium on the Interface, Seattle, April 22-24, 1991. Research assistance from Zhenyu Wang and financial support from National Science Foundation Grant SES-8908365 are gratefully acknowledged. The software for the examples may be requested by electronic mail, and will be returned by that medium. 2 1. Introduction The generation of random samples from a truncated multivariate normal distribution, that is, a ...
Broadband/Multiband Conformal Circular Beam-Steering Array (2006)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> A new approach for a broadband/multiband conformal circular beam-steering array is presented with both theory and experimental data. The array is low-profile, suitable for conformal mounting on a platform. It has an omnidirectional coverage with a unidirectional beam that aims at a moderate directivity of 5 to 15 dBi. It consists of a center driven element and parasitic surface waveguide elements symmetrically positioned in the periphery, for electronic beam steering and beam forming to enhance RF connectivity and/or spectral efficiency. This array can achieve ultrawideband multiband performance and low-profile conformability unattainable by conventional array approaches. In addition, its cost is estimated to be an order of magnitude lower than that of conventional beam-steering arrays. Breadboard and brassboard development efforts for the array have essentially achieved a bandwidth of 1.0–2.5 GHz. A larger bandwidth is feasible since its driven element has achieved a continuous 10:1 bandwidth, and since the surface waveguide elements could achieve a multioctave bandwidth similar to the broadbanding path from the Yagi-Uda array to the LP array. </para>
Identification of glycine spin systems in <sup>1</sup>H NMR spectra of proteins using multiple quantum coherences (1985)

Double-quantum filtered COSY and triple-quantum filtered COSY techniques have been compared for the tripeptide Gly-Tyr-Gly and for human lysozyme. The insertion of a triple-quantum filter in the COSY experiment leads to dramatic spectral simplification in the fingerprint region of the spectrum and permits the specific identification of glycine spin systems in the complex 1H NMR spectra of proteins. The assignment of these peaks to glycine H alpha can be confirmed using 2D double-quantum correlated spectroscopy.
Diazocyclopentadiene<sup>1</sup> (1953)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDiazocyclopentadiene1W. von E. Doering and C. H. DePuyCite this: J. Am. Chem. Soc. 1953, 75, 23, 5955–5957Publication Date (Print):December 1, 1953Publication History Published online1 May 2002Published inissue 1 December 1953https://doi.org/10.1021/ja01119a051Request reuse permissionsArticle Views1800Altmetric-Citations169LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (375 KB) Get e-Alertsclose Get e-Alerts
Negative-resistance effect in rubidium tetracyanoquinodimethane (Rb-TCNQ) (1991)

Nonlinear-conductivity phenomena, including negative-resistance and current-switching effects, have been observed in the radical-anion salt of rubidium tetracyanoquinodimethane (Rb-TCNQ) known as a spin-Peierls system. From the current and temperature dependences of infrared ${\mathit{a}}_{\mathit{g}}$ CN-stretching-vibration spectra, it is concluded that the observed nonlinear properties are not due to the Joule-heating effect but are attributable to the dynamics of soliton-type defects in the bond-ordered (dimerized) stacks of TCNQ molecules. The possible soliton-mediated transport mechanism in Rb-TCNQ is discussed, in parallel with previous discussions on similar nonlinear transport properties in mixed-stack organic charge-transfer crystals.
Target discovery of ebselen with a biotinylated probe (2018)

Despite numerous studies on ebselen over the past decade, its cellular targets remain obscure. Here we synthesized a biotinylated ebselen probe (biotin-ebselen) and characterized ebselen-binding proteins via an efficient activity-based protein profiling (ABPP) method, which allowed for the robust identification of 462 targeted proteins in HeLa cells. This first work of global target profiling of ebselen will be helpful to re-design ebselen-based therapy appropriately in clinical trials.
The benefit of leucovorin-modulated fluorouracil as postoperative adjuvant therapy for primary colon cancer: results from National Surgical Adjuvant Breast and Bowel Project protocol C-03. (1993)

Treatment with LV + 5-FU significantly prolongs disease-free survival and results in a significant benefit relative to overall survival. These findings, when considered together with results from a recent meta-analysis demonstrating a benefit from LV + 5-FU in advanced disease, provide evidence to support the concept of metabolic modulation of 5-FU.
A security framework for the analysis and design of software attestation (2013)

Software attestation has become a popular and challenging research topic at many established security conferences with an expected strong impact in practice. It aims at verifying the software integrity of (typically) resource-constrained embedded devices. However, for practical reasons, software attestation cannot rely on stored cryptographic secrets or dedicated trusted hardware. Instead, it exploits side-channel information, such as the time that the underlying device needs for a specific computation. As traditional cryptographic solutions and arguments are not applicable, novel approaches for the design and analysis are necessary. This is certainly one of the main reasons why the security goals, properties and underlying assumptions of existing software attestation schemes have been only vaguely discussed so far, limiting the confidence in their security claims. Thus, putting software attestation on a solid ground and having a founded approach for designing secure software attestation schemes is still an important open problem.