gebhart/patrepeval huggingface dataset:
Dynamic management of URL based on object-oriented paradigm (2002)

As the World Wide Web is popular, it is in high demand for retrieving the right information. In addition, the amount of information that is available has been increased. A search engine is used to locate information, due to the fact that searching for information from an increased amount of information is difficult. The search engine has started to use robot agents to facilitate easier access to the information. The paper proposes a dynamic URL management technique by using the object oriented paradigm for efficient performance of the robot agent. While URLs are saved in a file or database to decide whether the site is visited or not, this technique creates a URL object and pushes in a hash table. Therefore we can easily compare a new URL to others in a hash table which allows us to save, and insert a new URL if the URL is not in a hash table. This technique has the advantage of saving URL in a unique way. Other useful information about URL also can be stored. If the robot agent is suspended, we can save into files by using object serialization to save the main memory.
Managing adverse effects of glaucoma medications (2014)

Glaucoma is a chronic, progressive disease in which retinal ganglion cells disappear and subsequent, gradual reductions in the visual field ensues. Glaucoma eye drops have hypotensive effects and like all other medications are associated with adverse effects. Adverse reactions may either result from the main agent or from preservatives used in the drug vehicle. The preservative benzalkonium chloride, is one such compound that causes frequent adverse reactions such as superficial punctate keratitis, corneal erosion, conjunctival allergy, and conjunctival injection. Adverse reactions related to main hypotensive agents have been divided into those affecting the eye and those affecting the entire body. In particular, β-blockers frequently cause systematic adverse reactions, including bradycardia, decrease in blood pressure, irregular pulse and asthma attacks. Prostaglandin analogs have distinctive local adverse reactions, including eyelash bristling/lengthening, eyelid pigmentation, iris pigmentation, and upper eyelid deepening. No systemic adverse reactions have been linked to prostaglandin analog eye drop usage. These adverse reactions may be minimized when they are detected early and prevented by reducing the number of different eye drops used (via fixed combination eye drops), reducing the number of times eye drops are administered, using benzalkonium chloride-free eye drops, using lower concentration eye drops, and providing proper drop instillation training. Additionally, a one-time topical medication can be given to patients to allow observation of any adverse reactions, thereafter the preparation of a topical medication with the fewest known adverse reactions can be prescribed. This does require precise patient monitoring and inquiries about patient symptoms following medication use.
A Lack of SUMO Conjugation Affects cNLS-dependent Nuclear Protein Import in Yeast (2002)

Yeast SUMO (Smt3) and its mammalian ortholog SUMO-1 are ubiquitin-like proteins that can reversibly be conjugated to other proteins. Among the substrates for SUMO modification in vertebrates are RanGAP1 and RanBP2/Nup358, two proteins previously implicated in nucleocytoplasmic transport. Sumoylated RanGAP1 binds to the nuclear pore complex via RanBP2/Nup358, a giant nucleoporin, which was recently reported to act as a SUMO E3 ligase on some nuclear substrates. However, no direct evidence for a role of the SUMO system in nuclear transport has been obtained so far. By the use of conditional yeast mutants, we examined nuclear protein import in vivo. We show here that cNLS-dependent protein import is impaired in mutants with defective Ulp1 and Uba2, two enzymes involved in the SUMO conjugation reaction. In contrast, other transport pathways such as rgNLS-mediated protein import and mRNA export are not affected. Furthermore, we find that the yeast importin-alpha subunit Srp1 accumulates in the nucleus of ulp1 and uba2 strains but not the importin-beta subunit Kap95, indicating that a lack of Srp1 export might impair cNLS import. In summary, our results provide evidence that SUMO modification in yeast, as has been suspected for vertebrates, plays an important role in nucleocytoplasmic trafficking.
Metallomesogens presenting blue phases in a glassy state and in metallomesogen/nematic mixtures (1999)

J. Buey, P. Espinet, Heinz-S. Kitzerow and J. Strauss, Chem. Commun., 1999, 441 DOI: 10.1039/A900374F
Non-specific and Specific Adsorption of Proteins on Langmuir–Blodgett Films of Amino Acid Derivative Polymers (2001)

Abstract Polymer LB films consisting of lysine and alanine derivative polymers were prepared to investigate the interfacial recognition between protein and ligand on the LB film. The surface of lysine derivative polymer LB film was modified by the biotin molecule that is the ligand for avidin. The biotinylation was carried out without inducing non-specific adsorption of proteins; avidin specifically adsorbed onto the biotinylated surfaces. Moreover, it was found that there is an optimum molar ratio of biotinylation for the adsorption of avidin onto the surface.
Notes - N-Benzylidenebenzylamine from Benzylamine and Butyl Nitrite (1956)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNotes - N-Benzylidenebenzylamine from Benzylamine and Butyl NitriteRichard GillisCite this: J. Org. Chem. 1956, 21, 7, 805–808Publication Date (Print):July 1, 1956Publication History Published online28 February 2003Published inissue 1 July 1956https://pubs.acs.org/doi/10.1021/jo01113a609https://doi.org/10.1021/jo01113a609research-articleACS PublicationsRequest reuse permissionsArticle Views136Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Experimental investigation of the modulation phase-shift method for the measure of the chromatic dispersion in a single-mode fiber coiled on a covered spool (2005)

The measure of the chromatic dispersion of the optic fibers used in telecommunications networks and high-speed systems is very useful because it permits chromatic-dispersion compensators to be conceived across the wavelength range of interest. The modulation phase-shift method is used to measure chromatic dispersion in a standard single-mode fiber for telecommunication between 1200 and 1600 nm, by measuring the variation of the modulation phase of the transmitted signal modulated by a radio frequency signal, relative to the transmitted signal in a short reference fiber, modulated by the same signal. We verify the reduction of the thermal transitions in the measurement setup and fiber under test, while covering the spool of the fiber. © 2005 Wiley Periodicals, Inc. Microwave Opt Technol Lett 48: 174–178, 2006; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.21298
An improved network modeling of slot-coupled microstrip lines (1998)

This paper proposes an analytical method for slot-coupled microstrip lines with a view to developing an improved network model, which reflects the effects of inclination angles and offset distances. The network model consists of two ideal transformers and an extended slotline. The turn ratios are calculated by applying the reciprocity theorem with the spectral-domain immittance approach. The corresponding network models for several different configurations of these slot-coupled microstrip lines are then explored and shown to yield accurate scattering parameters.
DSIC: Deep Learning based Self-Interference Cancellation for In-Band Full Duplex Wireless (2018)

In-band full duplex wireless is of utmost interest to future wireless communication and networking due to great potentials of spectrum efficiency. IBFD wireless, however, is throttled by its key challenge, namely self-interference. Therefore, effective self-interference cancellation is the key to enable IBFD wireless. This paper proposes a real-time non-linear self-interference cancellation solution based on deep learning. In this solution, a self-interference channel is modeled by a deep neural network (DNN). Synchronized self-interference channel data is first collected to train the DNN of the self-interference channel. Afterwards, the trained DNN is used to cancel the self-interference at a wireless node. This solution has been implemented on a USRP SDR testbed and evaluated in real world in multiple scenarios with various modulations in transmitting information including numbers, texts as well as images. It results in the performance of 17dB in digital cancellation, which is very close to the self-interference power and nearly cancels the self-interference at a SDR node in the testbed. The solution yields an average of 8.5% bit error rate (BER) over many scenarios and different modulation schemes.
Study on the visible-light-induced photokilling effect of nitrogen-doped TiO2 nanoparticles on cancer cells (2011)

Nitrogen-doped TiO2 (N-TiO2) nanoparticles were prepared by calcining the anatase TiO2 nanoparticles under ammonia atmosphere. The N-TiO2 showed higher absorbance in the visible region than the pure TiO2. The cytotoxicity and visible-light-induced phototoxicity of the pure- and N-TiO2 were examined for three types of cancer cell lines. No significant cytotoxicity was detected. However, the visible-light-induced photokilling effects on cells were observed. The survival fraction of the cells decreased with the increased incubation concentration of the nanoparticles. The cancer cells incubated with N-TiO2 were killed more effectively than that with the pure TiO2. The reactive oxygen species was found to play an important role on the photokilling effect for cells. Furthermore, the intracellular distributions of N-TiO2 nanoparticles were examined by laser scanning confocal microscopy. The co-localization of N-TiO2 nanoparticles with nuclei or Golgi complexes was observed. The aberrant nuclear morphologies such as micronuclei were detected after the N-TiO2-treated cells were irradiated by the visible light.
Rapid and Simple Isolation of Zingiberene from Ginger Essential Oil (1998)

A sesquiterpene-enriched fraction of ginger oil was treated with the dienophile 4-phenyl-1,2,4-triazoline-3,5-dione (2), which selectively formed a Diels-Alder adduct with the sesquiterpene hydrocarbon zingiberene (1). The adduct was purified by flash chromatography, then hydrolyzed to return zingiberene in good yield and >99% purity.
Spontaneous Remission of Nephrotic Syndrome in Idiopathic Membranous Nephropathy (2010)

Spontaneous remission is a well known characteristic of idiopathic membranous nephropathy, but contemporary studies describing predictors of remission and long-term outcomes are lacking. We conducted a retrospective, multicenter cohort study of 328 patients with nephrotic syndrome resulting from idiopathic membranous nephropathy that initially received conservative therapy. Spontaneous remission occurred in 104 (32%) patients: proteinuria progressively declined after diagnosis until remission of disease at 14.7 +/- 11.4 months. Although spontaneous remission was more frequent with lower levels of baseline proteinuria, it also frequently occurred in patients with massive proteinuria: 26% among those with baseline proteinuria 8 to 12 g/24 h and 22% among those with proteinuria >12 g/24 h. Baseline serum creatinine and proteinuria, treatment with angiotensin-converting enzyme inhibitors or angiotensin receptor antagonists, and a >50% decline of proteinuria from baseline during the first year of follow-up were significant independent predictors for spontaneous remission. Only six patients (5.7%) experienced a relapse of nephrotic syndrome. The incidence of death and ESRD were significantly lower among patients with spontaneous remission. In conclusion, spontaneous remission is common among patients with nephrotic syndrome resulting from membranous nephropathy and carries a favorable long-term outcome with a low incidence of relapse. A decrease in proteinuria >50% from baseline during the first year predicts spontaneous remission.
Deconvolution of gene expression from cell populations across the C. eleganslineage (2013)

These simulations suggest that a high-resolution map of expression in the C. elegans embryo may be possible with expression data from as few as 30 cell populations.
Highly Autoproliferative T Cells Specific for 60-kDa Heat Shock Protein Produce IL-4/IL-10 and IFN-γ and Are Protective in Adjuvant Arthritis (2000)

Previously we have shown that T cell responses to the mycobacterial 60-kDa heat shock protein (hsp60) peptide M256-270 mediated protection against adjuvant arthritis in Lewis rats. We have demonstrated now that M256-270-primed T cells become highly reactive to naive syngeneic APC upon repetitive restimulation in vitro with peptide M256-265, comprising the conserved core of peptide M256-270. These autoproliferative responses in the absence of added Ag were MHC class II restricted and resulted in the production of IL-4/IL-10 and IFN-gamma. Enhanced autoproliferation and expression of the cell surface molecule B7.2 by these T cells were observed in response to syngeneic heat-shocked APC, which indicated that the autoproliferation and expression of B7.2 resulted from the recognition of endogenously expressed and processed hsp. Despite their strong autoreactivity, upon transfer such T cells were found to induce a significant disease reduction in adjuvant arthritis. In contrast, T cells both primed and restimulated with peptide M256-270 became unresponsive toward syngeneic APC as well as toward the conserved core peptide M256-265, and they were devoid of protective capacity. This study demonstrates that the loss of self-tolerance toward hsp60 does not necessarily lead to autoimmune disease, but that hsp60-specific self-reactive and autoproliferative T cells may mediate T cell regulation in arthritis.
Comparison of extraction techniques for munitions residues in soil (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTComparison of extraction techniques for munitions residues in soilThomas F. Jenkins and Clarence L. GrantCite this: Anal. Chem. 1987, 59, 9, 1326–1331Publication Date (Print):May 1, 1987Publication History Published online1 May 2002Published inissue 1 May 1987https://pubs.acs.org/doi/10.1021/ac00136a015https://doi.org/10.1021/ac00136a015research-articleACS PublicationsRequest reuse permissionsArticle Views225Altmetric-Citations45LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Las tarifas de los servicios urbanos de agua en España: tamaño del hogar y equidad (2011)

Habitualmente, las tarifas que gravan el consumo de agua pretenden lograr
simultaneamente la financiacion del servicio, el reparto de los costes entre sus usuarios, la
asignacion del agua entre sus demandantes y la conservacion del recurso. Por ello, el diseno
de estas tarifas suele someterse a criterios normativos como los de suficiencia, equidad,
eficiencia y sencillez. En este trabajo se analizan las tarifas vigentes en 2008 en las capitales
de provincia espanolas desde la perspectiva de la equidad en el tratamiento de los usuarios.
Al respecto, dado que se trata de un servicio publico cuyos beneficios son en su mayor parte
divisibles, adoptamos el principio del beneficio como base para el establecimiento de un
criterio de equidad operativo. En particular, nos interesa evaluar las consecuencias para la
equidad de la existencia de tarifas con precios crecientes que gravan el consumo agregado del
hogar, que suelen ocasionar que la satisfaccion de las necesidades basicas de agua de los
individuos resulte mas gravosa cuanto mayor es el tamano del hogar al que pertenecen.
Ademas, prestamos una atencion muy especial al efecto sobre la equidad de las tarifas
especiales para los hogares de mayor tamano que han sido introducidas en numerosas
ciudades para hacer frente a los problemas de trato discriminatorio que pueden afectar a los
residentes en este tipo de hogares. El estudio realizado confirma la existencia de problemas
de equidad en el tratamiento de los distintos usuarios del servicio �asociadas al tamano del
hogar de pertenencia-, que perjudican especialmente a los hogares grandes, aunque no solo a
ellos, y que gran parte de las tarifas especiales adoptadas en las capitales de provincia
espanolas no resultan adecuadas para darles solucion.
DC magnetic fields from the human body generally: a historical overview. (2004)

A review is presented of the earliest dc magnetic field (dcMF) measurements, made between 1969 and 1983, due to natural currents in the body. The measurements were essentially a mapping over the whole body, except for the brain (dcMEG), which was omitted because of interfering non-neural sources in the head. This mapping can be useful today in interpreting new measurements over the body, especially dcMEG data, where the new authors assume only a neural source in the head; our mapping suggests that this assumption may be in error. Briefly, in our mapping, dcMFs were found over almost the entire body; they were larger over the limbs and head than over the torso proper except over the abdomen, where it was usually the largest in the body Some of the sources were: 1. A strong and complicated reflex in the abdomen due to drinking cold water, suggesting that other dcMF reflexes might be common in the body. 2. Long muscle fibers in the limbs, suggesting sources also in scalp muscles. 3. Hair follicles due to touching the scalp; these sources could also exist, unrecognized, in recent dcMEG whole-head measurements. 4. Injury currents from the ischemic human heart, suggesting dcMFs could arise from injured muscle in the body generally. One major mechanism for producing dcMFs appeared to be a change in the potassium ion concentration in the vicinity of long excitable fibers. Overall, we concluded that the dcMFs were complicated, and it may be difficult to identify each source, especially in the head.
Specific IgE to fish extracts does not predict allergy to specific species within an adult fish allergic population (2014)

Serological cross-reactivity between fish species is frequent, but in a significant proportion of patients, clinical relevance appears to be limited to only certain species. A well-taken history or food challenge is required for discrimination between allergy to the different fish species.
Synthesis and structure-activity relationships of a series of anxioselective pyrazolopyridine ester and amide anxiolytic agents (1989)

A series of 1-substituted 4-amino-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid esters and amides were synthesized and screened for anxiolytic activity in the shock-induced suppression of drinking (SSD) test. The compounds were also tested for their ability to displace [3H]flunitrazepam (FLU) from brain benzodiazepine (BZ) binding sites. Many compounds were active in these screens and, additionally, demonstrated a selectivity for the type 1 BZ (BZ1) receptor over the type 2 BZ (BZ2) receptor as indicated by Hill coefficients significantly less than unity and by analysis of [3H]FLU binding results from different brain regions. Based on the results of structure-activity studies of these compounds, a hypothesis was proposed to explain the structural features necessary for optimal interaction with brain BZ receptors. A detailed pharmacological evaluation of one of the most potent behaviorally active compounds (27) demonstrated it to be BZ1 selective; also, in comparison to diazepam, 27 showed minimal sedative and alcohol interactive properties at therapeutically effective doses.
Magnetic Luminescent Porous Silicon Microparticles for Localized Delivery of Molecular Drug Payloads (2010)

Magnetic manipulation, fluorescent tracking, and localized delivery of a drug payload to cancer cells in vitro is demonstrated, using nanostructured porous silicon microparticles as a carrier. The multifunctional microparticles are prepared by electrochemical porosification of a silicon wafer in a hydrofluoric acid-containing electrolyte, followed by removal and fracture of the porous layer into particles using ultrasound. The intrinsically luminescent particles are loaded with superparamagnetic iron oxide nanoparticles and the anti-cancer drug doxorubicin. The drug-containing particles are delivered to human cervical cancer (HeLa) cells in vitro, under the guidance of a magnetic field. The high concentration of particles in the proximity of the magnetic field results in a high concentration of drug being released in that region of the Petri dish, and localized cell death is confirmed by cellular viability assay (Calcein AM).
Ethylene formation by methane dehydrogenation and C–C coupling reaction on a stoichiometric IrO<sub>2</sub> (110) surface – a density functional theory investigation (2015)

The capability to activate methane at mild temperature and facilitate all elementary reactions on the catalyst surface is a defining characteristic of an efficient catalyst especially for the direct conversion of methane to ethylene.
Anti-Tumor Necrosis Factor Therapy in Intestinal Beh Ccedil;et rsquo;s Disease (2018)

Intestinal Behet's disease is a rare, immune-mediated chronic intestinal inflammatory disease; therefore, clinical trials to optimize the management and treatment of patients are scarce. Moreover, intestinal Behet's disease is difficult to treat and often requires surgery because of the failure of conventional medical treatment. Administration of anti-tumor necrosis factor-, a potential therapeutic strategy, is currently under active clinical investigation, and evidence of its effectiveness for both intestinal Behet's disease and inflammatory bowel diseases has been accumulating. Here, we review updated data on current experiences and outcomes after the administration of anti-tumor necrosis factor- for the treatment of intestinal Behet's disease. In addition to infliximab and adalimumab, which are the most commonly used agents, we describe agents such as golimumab, etanercept, and certolizumab pegol, which have recently been shown to be effective in refractory intestinal Behet's disease. This review also discusses safety issues associated with anti-tumor necrosis factor-, including vulnerability to infections and malignancy. (