gebhart/patrepeval huggingface dataset:
Searching for Metal-Binding Domains (1989)

In recent years several families of proteins with nucleic acid binding or gene regulatory activities have been discovered to contain short stretches of amino acids that bind metal ions through invariant cysteine and/or histidine residues. These have been termed metal-binding domains. A wide spectrum of methods for identifying additional members of these families have been developed. Four such methods are: (i) screening DNA libraries by hybridization to single stranded nucleic acid probes that are derived from known metal-binding domains; (ii) examining protein sequence libraries via computer for patterns of cysteines and/or histidines; (iii) developing genetic screens for metal ion-dependent phenotypes; and (iv) investigating the metal ion dependence of biochemical activities such as nucleic acid binding. Examples of each of these approached are described.
Lipid-bound saccharides in Rhizobium meliloti. (1982)

The lipid-bound saccharides formed by incubation of uridine diphosphate glucose with a particulate enzyme of Rhizobium meliloti were studied. They behaved like polyprenyl diphosphate saccharides when treated with ammonia or hot phenol, when catalytically hydrogenated, and on DEAE-cellulose chromatography. The saccharide moieties obtained after heating at pH 2 for 10 min at 100 degrees C were separated with a gel filtration column. The following compounds were detected: galactose, glucosyl beta 1-3 galactose (Tolmasky, M. E., Staneloni, R. J., Ugalde, R. A., and Leloir, L. F. (1980) ARch. Biochem. Biophys. 203, 358-364), and some octasaccharides (I). These were compared by paper electrophoresis, thin layer and paper chromatography with an octasaccharide obtained from Alcaligenes faecalis var. myxogenes strain 11 (II). Furthermore, Compounds I and II were compared with the exopolysaccharide of Rhizobium meliloti (III) by partial acid hydrolysis and methylation analysis. The results were consistent with the identity of the repeating unit of Compound III with Compounds I and II except for differences in the substituents (acetyl or succinyl). Studies on the labeling of the lipid-bound saccharides have shown that the sequence is: first, galactose and glucosyl beta 1-3 galactose, then the rest of glucose residues, and finally, the substituents (acetyl and pyruvic acid).
Shock-induced alterations in hemostasis. (1986)

The major constituents of the hemostatic potential, i.e., platelets and the plasma factors of coagulation and fibrinolysis, guarantee the integrity of the vessel wall and provide effective hemostasis in case of vascular damage. The equilibrium between anticoagulant and procoagulant forces which is essential for the maintenance of the fluidity of blood is controlled by inhibitors, the fibrinolytic system, and the clearance of activated components by the reticuloendothelial system. The proper function of this humoral balance is essentially dependent on hemodynamic factors such as adequate circulation and capillary perfusion.
The Somatostatin Analog SMS 201-995 Induces Long-Acting Inhibition of Growth Hormone Secretion without Rebound Hypersecretion in Acromegalic Patients* (1985)

The acute effect of the somatostatin analog SMS 201-995 (SMS) was investigated in eight acromegalic patients. This substance is an octapeptide [DPhe-Cys-Phe-D-Trp-Lys-Thr-Cys-Thr-(ol)] that inhibits GH release in experimental animals and man. After a control day, 50 micrograms SMS were injected sc, and plasma GH and insulin and blood glucose levels were measured at multiple intervals for 24 h. GH significantly (P less than 0.001) decreased in seven of eight acromegalic patients from 30 +/- 5 (+/- SE) to an average of 10.7 +/- 4 micrograms/l from 1-10 h after drug administration. No rebound effect occurred. Postprandial blood glucose levels were significantly (P less than 0.01) higher between 2 and 4 h after SMS treatment compared with control day values, and there was a substantial reduction in insulin secretion, as estimated by the area under the curve (P less than 0.01), during the first 3 h after SMS administration. Circulating GH was not altered by SMS or the dopamine agonist mesulergine in one patient, but the combination of both substances (50 micrograms SMS, sc, and 0.5 mg mesulergine, orally) reduced GH to below 50% of basal. In vitro studies showed that 1 PM, 0.1 nM, and 10 nM SMS or natural somatostatin exerted a similar inhibitory effect (12-39% reduction; P less than 0.01 for all three strengths) on GH release by cultured human pituitary tumor cells. In conclusion, the somatostatin derivative SMS exerts a potent and prolonged inhibitory action on GH secretion and a shorter lasting suppression of insulin in acromegalic patients. Therefore, it may represent a useful tool in the chronic management of this condition.
Small Heat Shock Proteins Potentiate Amyloid Dissolution by Protein Disaggregases from Yeast and Humans (2012)

How small heat shock proteins (sHsps) might empower proteostasis networks to control beneficial prions or disassemble pathological amyloid is unknown. Here, we establish that yeast sHsps, Hsp26 and Hsp42, inhibit prionogenesis by the [PSI+] prion protein, Sup35, via distinct and synergistic mechanisms. Hsp42 prevents conformational rearrangements within molten oligomers that enable de novo prionogenesis and collaborates with Hsp70 to attenuate self-templating. By contrast, Hsp26 inhibits self-templating upon binding assembled prions. sHsp binding destabilizes Sup35 prions and promotes their disaggregation by Hsp104, Hsp70, and Hsp40. In yeast, Hsp26 or Hsp42 overexpression prevents [PSI+] induction, cures [PSI+], and potentiates [PSI+]-curing by Hsp104 overexpression. In vitro, sHsps enhance Hsp104-catalyzed disaggregation of pathological amyloid forms of α-synuclein and polyglutamine. Unexpectedly, in the absence of Hsp104, sHsps promote an unprecedented, gradual depolymerization of Sup35 prions by Hsp110, Hsp70, and Hsp40. This unanticipated amyloid-depolymerase activity is conserved from yeast to humans, which lack Hsp104 orthologues. A human sHsp, HspB5, stimulates depolymerization of α-synuclein amyloid by human Hsp110, Hsp70, and Hsp40. Thus, we elucidate a heretofore-unrecognized human amyloid-depolymerase system that could have applications in various neurodegenerative disorders.
TEACHERS FROM INDUSTRY … 1 (1962)

first of a new series designed to be of special interest to the new college teacher — and the potential recruit
Back Pain and Backpacks in School Children (2006)

The incidence of back pain in early adolescence approaches that seen in adults. Recommendations for an "acceptable" weight of backpacks cannot be made from this study, as the weights of students' backpacks seem directly proportional to the likelihood of back pain. This study identifies 2 factors associated with self-reported back pain in early adolescents that are amenable to change: availability of school lockers and lighter backpacks. These findings may be useful in advising families and influencing school policies.
Composition dependence of defect energies and band alignments in the Cu(In1−xGax)(Se1−ySy)2 alloy system (2002)

The composition dependence of defect energies in polycrystalline Cu(In1−xGax)(Se1−ySy)2 chalcopyrite thin films is investigated by admittance spectroscopy of ZnO/CdS/chalcopyrite heterojunctions. We determine the band alignments within the polycrystalline Cu(In1−xGax)(Se1−ySy)2 semiconductor system using the energy position of the dominant acceptor state as a reference level. Upon alloying CuInSe2 with S the activation energy of the acceptor increases from 300 meV to approximately 380 meV in CuIn(Se0.4S0.6)2. A similar result holds when using Cu(In1−xGax)(Se1−ySy)2 with x≈0.3. In contrast, the acceptor activation energy remains essentially unchanged in the Cu(In1−xGax)Se2 alloy system over the whole composition range 0⩽x⩽1. Taking the acceptor energy as reference, we find a valence band offset ΔEV=−0.23 eV between CuInSe2 and CuInS2. The same valence band offset is found between Cu(In0.7Ga0.3)Se2 and Cu(In0.7Ga0.3)S2. In contrast, the combination CuInSe2/CuGaSe2 displays ΔEV below 0.04 eV. Our results indicate that a bulk reference level exists in the Cu(In1−xGax)(Se1−ySy)2 semiconductors which sets the band structure on a common energy scale, thus establishing the natural band lineups within the alloy system automatically. This conclusion is sustained by our finding that the position of the Fermi level at the CdS/chalcopyrite interface exhibits a constant energy distance to the acceptor level. The concentration of bulk acceptors is in addition correlated to the open circuit voltage losses of heterojunction solar cells.
Phosphodiesterase 4 Inhibitors for the Treatment of Asthma and COPD (2006)

Type 4 cyclic nucleotide phosphodiesterases (PDE4s) are metallo-hydrolases which specifically hydrolyze cAMP to AMP in various cells types. The catalytic core is a bimetallic ion center composed of a tightly bound Zn(2+) and a loosely bound Mg(2+), which plays a dictating role in eliciting cAMP binding and catalysis activation. An invariant glutamine positioned opposite to the ion center serves as the substrate recognition determinant and synergizes the transient Mg-oxo-phosphate interaction in the substrate complex. The Mg(2+) binding is activated by a PKA-mediated serine phosphorylation and modulated through protein-protein interactions, thus, providing efficient mechanisms in the temporal regulation of cAMP signaling. Several PDE4 inhibitors including roflumilast, cilomilast and rolipram also rely on the interaction with the glutamine and metallic ion center for binding, with their affinity enhanced dramatically by the presence of the Mg(2+) ion. Recent studies have provided new insights into the role of this enzyme in inflammatory settings, CFTR regulation, long term potentiation, and its importance in immune surveillance. The major inflammatory cytokines which are modulated with PDE4 inhibitors include TNFalpha, IL-2, IFNgamma, IL-12, GM-CSF and LTB(4). The role of PDE4 inhibitors in modulating cytokines, lipid mediators and in mucociliary clearance, along with clinical efficacy in asthma and/or COPD demonstrated with roflumilast and cilomilast, suggest a broad anti-inflammatory spectrum for these compounds. Presently, the major impediment to approval of these novel therapies has been the mechanism based gastrointestinal adverse events which has limited the dosing and the ultimate efficacy with these novel therapeutic agents.
An ADC BIST with on-chip ramp generator (2007)

This work presents built-in self-test (BIST) techniques for the production testing of mixed signal circuits. The special test strategy for the typical mixed-signal component analog-to-digital converter (ADC) is discussed. The traditional test for such mixed-signal components can be completed through a DSP-based mixed-signal tester with an arbitrary waveform generator and a signal digitizer, but such a test is very costly and time consuming. Hence, a BIST strategy based on an on chip ramp generator (OCRG) is proposed in this work for testing ADC. This BIST method has an advantage testing ADC without DAC to overcome area overhead. This BIST method realizes the test controller, test pattern generation and output response analyser at the aspect of the on-chip circuitry. The demonstration of the proposed BIST is given through various simulation results in the last parts of this work.
Design and Implementation of a Novel Single-Phase Switched Reluctance Motor Drive System (2002)

Single phase switched reluctance machines (SRMs) have a special place in the emerging high-volume, low-cost and low-performance applications in appliances and also in high-speed low-power motor drives in various industrial applications. Single phase SRMs have a number of drawbacks: low power density as they have only 50% utilization of windings, lack of self-starting feature unless otherwise built in to the machine, most of the times with permanent magnets or sometimes with distinct and special machine rotor configurations or additional mechanisms. Many of these approaches are expensive or make the manufacturing process more difficult. In order to overcome such disadvantages a method involving interpoles and windings is discussed in this research. Also, a new and novel converter topology requiring only a single switch and a single diode is realized.\nThis research tests the concepts and feasibility of this new single-phase SRM motor topology and converter in one quadrant operation. The converter electronics and a simple minimum component, minimum cost analog converter are designed and implemented. The entire system is simulated and evaluated on its advantages and disadvantages. Simple testing without load is performed.\nThis system has a large number of possibilities for development. Due to its lightweight, compact design and efficient, variable high-speed operation, the system might find many applications in pumps, fans, and drills.
Paged cache: an efficient partition architecture for reducing power, area and access time (2003)

Power consumption is an increasingly pressing problem in high performance processors, and the caches usually consume a significant amount of power. This paper presents a new cache partition architecture, called paged cache, which is beneficial for area, power and performance. In paged cache, we divide the entire cache into a set of partitions, and each partition is dedicated to only one page cached in the TLB (translation lookaside buffer). By restricting the range in which the cached block can be placed, we can eliminate the total or partial tag depending on the partition size. Furthermore, by accessing only a single partition, instead of accessing the entire cache, both the power consumption per cache access and the average access time can be reduced largely. We use SimpleScalar to simulate the SPEC2000 benchmarks and perform the HSPICE simulations (with 0.18 /spl mu/m technology and 1.8 V voltage supply) to evaluate the proposed architecture. Experimental results show that the paged cache is very efficient in reducing both power consumption and tag area of the on-chip L1 caches, while the average access time of cache can be improved.
NADH dehydrogenase of Corynebacterium glutamicum. Purification of an NADH dehydrogenase II homolog able to oxidize NADPH (2001)

NADPH oxidase activity, in addition to NADH oxidase activity, has been shown to be present in the respiratory chain of Corynebacterium glutamicum. In this study, we tried to purify NADPH oxidase and NADH dehydrogenase activities from the membranes of C. glutamicum. Both the enzyme activities were simultaneously purified in the same fraction, and the purified enzyme was shown to be a single polypeptide of 55 kDa. The N-terminal sequence of the enzyme was consistent with the sequence deduced from the NADH dehydrogenase gene of C. glutamicum, which has been sequenced and shown to be a homolog of NADH dehydrogenase II. In addition to high NADH–ubiquinone-1 oxidoreductase activity at neutral pH, the purified enzyme showed relatively high NADPH oxidase and NADPH–ubiquinone-1 oxidoreductase activities at acidic pH. Thus, NADH dehydrogenase of C. glutamicum was shown to be rather unique in having a relatively high reactivity toward NADPH.
Long-Term Pain Vulnerability After Surgery in Rats: Prevention by Nefopam, an Analgesic with Antihyperalgesic Properties (2009)

Given preemptively, nefopam may be effective at improving postoperative pain management and at reducing the risk of developing postoperative chronic pain, because the drug has both analgesic and antihyperalgesic properties.
A Comparison of Various Routes of Newcastle Disease Vaccination at One Day of Age (1976)

Groups of 100 one-day-old chicks with moderate levels of maternal antibody were vaccinated with the B1 strain of Newcastle disease virus subcutaneously, intratracheally, intraocularly or by aerosol or were left unvaccinated. Certain of these groups were revaccinated at 9 or 9 and 28 days or at 14 or 14 and 28 days with the LaSota strain of Newcastle disease virus. Vaccination by all routes at one day of age resulted in an antibody response and increased resistance to challenge. The most effective route was by aerosol followed by the intraocular method. Intratracheal administration or subcutaneous inoculation led to a marginal response. Aerosol administration at 9 or 9 and 28 days or at 14 or 14 and 28 days gave adequate antibody responses and resistance to challenge.
Treatment of Water by Granular Activated Carbon (1983)

Past EPA actions affecting the water utility industry and the basis for EPA regulatory actions are reviewed. Ongoing regulatory efforts of the Office of Drinking Water are focusing on implementation of the trihalomethane regulations, development of an Advance Notice of Proposed Rulemaking for volatile organic chemicals, and National Revised Primary Drinking Water Regulations. Current research needs of the EPA, including a call for participation in the EPA Competitive Grants Program, are outlined.
Colloidal synthesis of MoS<sub>2</sub> quantum dots: size-dependent tunable photoluminescence and bioimaging (2015)

A facile colloidal method was designed to prepare fluorescent MoS<sub>2</sub> QDs. The resultant QDs showed size-dependent tunable photoluminescence and could be used for bioimaging.
P276-00, a cyclin-dependent kinase inhibitor, modulates cell cycle and induces apoptosis in vitro and in vivo in mantle cell lymphoma cell lines (2012)

Our studies thus provide evidence and rational that P276-00 alone or in combination is a potential therapeutic molecule to improve patients' outcome in mantle cell lymphoma.
Phosgene (2010)

Abstract Phosgene is a colorless, low boiling liquid which is manufactured by the reaction of carbon monoxide and chlorine over activated carbon. It is a very toxic substance and extensive safety procedures and equipment have been developed to help ensure safety of handling. Because of its low boiling point and high toxicity, measures must be taken to prevent the entrance of phosgene into sewers and drains. Phosgene is a widely used intermediates. Practically all phosgene is captive, ie, used in the manufacture of other chemicals within the plant boundary. The major portion of phosgene produced goes into the production of isocyanates. It is also used in the production of polycarbonates and fine chemicals. The possiblity of phosgene–free technology may impact the market for phosgene.
[Refined deletion mapping of loss of heterozygosity on 22q13 in sporadic colorectal carcinoma]. (2006)

Two obvious high frequency LOH regions are detected by refined deletion mapping. One locates between D22S1171 locus and D22S274 locus (about 2.7 cM); another locates between D22S1160 and D22S1149 locus (about 1.8cM), ARHGAP8 and PPARA gene may be TSGs which contribute to carcinogenesis and progression of sporadic CRC on 22q13 region.
Prevention And Treatment Of Cytomegalovirus Infection (1991)

Postpartum depression (PPD) is common, disabling, and treatable. The strongest risk factor is a history of mood or anxiety disorder, especially having active symptoms during pregnancy. As PPD is one of the most common complications of childbirth, it is ...Read More
Myasthenia gravis and rheumatoid spondylitis. Coexistence in three cases. (1965)

RECENTLY, we observed a patient having myasthenia gravis and long-standing rheumatoid (ankylosing) spondylitis. The coexistence of these two relatively uncommon diseases was unusual in our experience, and a review of the English literature failed to reveal any previously reported cases. However, review of the case histories of the 857 patients having myasthenia gravis who were seen at the Mayo Clinic from 1934 to July 1964 yielded two other cases. These three cases are the subject of this report. Report of Cases Case 1.— A 55-year-old married white man, an electrician, entered the hospital on March 13, 1964, because of diplopia and ptosis of the upper eyelids. The diplopia had begun in September 1962, but it had not become severe until December 1963, when the ptosis began. Myasthenia gravis had been diagnosed, and the patient had responded well to treatment with pyridostigmine (Mestinon) bromide. However, in February 1964 his symptoms had
Photochemically induced isothermal phase transition in polymer liquid crystals with mesogenic phenyl benzoate side chains. 2. Photochemically induced isothermal phase transition behaviors (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotochemically induced isothermal phase transition in polymer liquid crystals with mesogenic phenyl benzoate side chains. 2. Photochemically induced isothermal phase transition behaviorsTomiki Ikeda, Shin Horiuchi, Durga B. Karanjit, Seiji Kurihara, and Shigeo TazukeCite this: Macromolecules 1990, 23, 1, 42–48Publication Date (Print):January 1, 1990Publication History Published online1 May 2002Published inissue 1 January 1990https://pubs.acs.org/doi/10.1021/ma00203a009https://doi.org/10.1021/ma00203a009research-articleACS PublicationsRequest reuse permissionsArticle Views644Altmetric-Citations180LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Influence of sewing parameters upon the tensile behavior of textile assembly (2006)

Purpose The aim of this work is to check the influence of some sewing parameters upon the tensile behaviour of a textile assembly (assembly of two woven samples by a seam). Design/methodology/approach This analysis was carried out according to the approach “experimental design”. The studied parameters are the sewing thread, the stitch type, the stitch density, the needle size and the edge of seam. The targeted answers are drawn from the tensile test on the assembly: breaking strength, breaking elongation and deformation energy. Findings In order to highlight the behaviour of the seam, a load‐extension curve for the stitch line is established: it represents, for a value of a given tensile effort, the difference between the displacement of the assembly and that of the fabric. From this curve, breaking elongation as well as the deformation energy are determined. Originality/value An “experimental design” was carried out and analysed for two types of assembly (warp and weft). Linear models predicting each response were established.