gebhart/patrepeval huggingface dataset:
Anti-HIV-1 Gene Expressing Lentiviral Vectors as an Adjunctive Therapy for HIV-1 Infection (2004)

Lentiviral based gene therapy may provide a valuable addition to the current anti-HIV arsenal. Many lentiviral vector systems have been described including those based on feline immunodeficiency virus (FIV), human immunodeficiency virus 1 (HIV) and 2 (HIV-2/SIV) as well as replication incompetent, self-inactivating (sin) vs. conditionally replicating (mobilizable) vectors. Lentiviral vectors offer promise in treating HIV-1 infection as they are capable of stably transducing both dividing and nondividing cells, specifically those cells involved in HIV-1 replication and immune restoration: T-cells, hematopoietic stem cells, and dendritic cells. Moreover, some of the HIV-1 and 2 based vectors can be mobilized by wildtype HIV-1 in vivo and spread to those cells targeted by the virus as well as can compete with viral RNA for packaging and access to viral proteins such as Tat and Rev required for viral replication. Finally, lentiviral vectors can be designed to express therapeutic anti-HIV-1 genes, which specifically target various stages of viral replication. Many candidate RNA based anti-HIV-1 genes have been expressed from lentiviral vectors including ribozymes and anti-sense RNA [1]. Recently, small interfering RNAs (siRNAs) have been shown to potently suppress HIV replication [2-6]. This review will focus on the current status of lentiviral vector development and the feasibility of using lentiviral vectors in delivering anti-HIV genes, specifically ribozymes, and siRNAs as a therapeutic approach to employ in conjunction with current anti-retroviral therapies.
付梦妮 武艺 我们要《在一起》! (2012)

在一起领衔主演付梦妮武艺在快女舞台合唱《小酒窝》之后,可爱盟主武艺和最萌快女付梦妮再度联手拍摄青春微电影《敢不敢之在一起》,对应这部电影的主题莽撞,迷失,癫狂,撕心裂肺,如果是因为爱,怎么都值得。让人疑惑一向都是乖小孩示人的两位,不知他们将如何演绎这部纯爱电影。
The Local Wavelet Transform: a memory-efficient, high-speed architecture optimized to a Region-Oriented Zero-Tree coder (2000)

The memory required for the implementation of the 2D wavelet transform typically incurs relatively high power consumption and limits the speed performances. In this paper we propose an optimized ar...
Reduction of Residual Vibrations in Positioning Control Mechanism (1985)

This paper clarifies numerically and experimentally the characteristics of residual vibrations caused by the natural frequency variation for a positioning mechanism, such that a load modeled as a one-degree-of-freedom vibratory system is driven by a servomotor. Moreover, a multi-design-point method is proposed, which can reduce residual vibrations over a comparatively wide range of parameter variations. It is also shown that this method enables high-speed and accurate positioning for a serial printer carriage.
Identification of Flavonoids and Cinnamic Acid Derivatives from Spinach Chloroplast Preparations (1972)

By immunochemical methods we had presented evidence for a primary acceptor complex for photosystem I of photosynthetic electron transport. During purification of this complex, obtained as a water soluble fraction from ether treated lyophilized chloroplasts, two low molecular fractions are also obtained, which may or may not have relation to the primary acceptor. The purification and identification of these low molecular fractions is reported. One, absorbing at 275 and 335 nm, consists of several flavonoid glycosides. The aglycon of the main component is tentatively identified as a 3-methyl-6,7-methylenedioxy-quercetagetin. The chromophore of the other low molecular fraction, absorbing at 312 nm, contains two cinnamic acid derivatives, which on alkaline hydrolysis yield p-coumaric acid. The relation of the two low molecular fractions to other fractions of various activity isolated from chloroplasts is discussed.
Desynchronization by Means of a Coordinated Reset of Neural Sub-Populations (2003)

The coordinated reset of neural sub-populations is introduced as an effectively desynchronizing stimulation technique. For this, short sequences of high-frequency pulse trains are administered at different sites in a coordinated way, i.e. separated by suitable fixed delays. Desynchronization is effectively maintained by performing a coordinated reset with demand-controlled timing or by periodically administering resetting high-frequency pulse trains of demand-controlled length. Unlike previously developed methods, this novel approach is robust against variations of model parameters, and does not require time-consuming calibration. I suggest the novel technique to be used for demand-controlled deep brain stimulation in patients suffering from Parkinson's disease or essential tremor. Furthermore, the novel stimulation method might even be applicable to diseases with intermittently emerging synchronized neural oscillations like epilepsy.
Marketing the library (1987)

I have a confession to make. I wrote a paper, The marketing of libraries , which turned out to be a poor man's Blaise Cronin. My sin was not to ask the elementary questions of the Aslib request for my presence — namely: ‘What, when, where and why?’ Had I done so I would have got to ‘Why’ and saved myself some hours of writing and research. Why then did Aslib ask me? The answer must be that Sutton has succeeded in crashing the normally impenetrable barrier between public and special libraries. Possibly its razzmatazz, its well‐oiled publicity machine — even its maverick temerity to accept that libraries are not, and probably cannot be, ‘open and free’, may have struck a spark in your conference organising committee's consciousness.
Chemical sensing with micromolded plastic microcantilevers (2005)

This paper describes microcantilever sensors produced via injection molding. The injection mold design is novel in that it employs one floating and one fixed mold half, hence only necessitating high flatness on two surfaces (e.g., the mating surfaces of the mold), whereas the remainder of the mold can be machined to only moderate tolerances. The mold holds a sub-100 nanometer flatness error over the entire mold mating surfaces, needed to produce micro- and nanoscale parts. Micrometer-scale cantilevers are produced and characterized as a test case. Microcantilevers are fabricated from three different polymeric materials and have exceptional repeatability as evidenced by their measured first-mode bending resonant frequencies. As a precursor to biological sensing, gold-thiol chemical sensing results obtained with the injection-molded cantilevers are also presented and show values that agree with the literature. As a whole, this work shows that the polymeric microcantilever parts fabricated via injection molding are mechanical and functional equivalents to their silicon-type counterparts, and are cheaper and easier to manufacture. [1483].
Estimating surface-roughness loss and output coupling in microdisk resonators (1996)

The volume current method is used to estimate analytically the scattering losses that are due to boundary corrugations and surface roughness in microdisk and ring resonators. The harmonic components of boundary imperfections either phase match the unguided continuum or lead to tunneling radiation. Phase-matched radiation can contribute significant loss and is only weakly dependent on disk radius. In high-index contrast devices the longitudinal electric field component is thus responsible for most of the radiation.
The return map: Tracking product teams (1991)

With a new product, time is now more valuable than money. The costs of conceiving and designing a product are less important to its ultimate success than timeliness to market. One of the most important ways to speed up product development is through interfunctional teamwork. The "Return Map," developed at Hewlett-Packard, provides a way for people from different functions to triangulate on the product development process as a whole. It graphically represents the contributions of all team members to the moment when a project breaks even. It forces the team to estimate and re-estimate the time it will take to perform critical tasks, so that products can get out fast. It subjects the team to the only discipline that works, namely, self-discipline. The map is, in effect, a graph representing time and money, where the time line is divided into three phases: investigation, development, and manufacturing and sales. Meanwhile, costs are plotted against time--as are revenues when they are realized after manufacturing release. Within these points of reference, four novel metrics emerge: Break-Even-Time, Time-to-Market, Break-Even-After-Release, and the Return Factor. All metrics are estimated at the beginning of a project to determine its feasibility, then they are tracked carefully while the project evolves to determine its success. Missed forecasts are inevitable, but managers who punish employees for missing their marks will only encourage them to estimate conservatively, thus building slack into a system meant to eliminate slack. Estimates are a team responsibility, and deviations provide valuable information that spurs continuous investigation and improvement.
Opioid Abuse in Chronic Pain — Misconceptions and Mitigation Strategies (2016)

Chronic pain not caused by cancer is among the most prevalent and debilitating medical conditions but also among the most controversial and complex to manage. The urgency of patients’ needs, the demonstrated effectiveness of opioid analgesics for the management of acute pain, and the limited therapeutic alternatives for chronic pain have combined to produce an overreliance on opioid medications in the United States, with associated alarming increases in diversion, overdose, and addiction. Given the lack of clinical consensus and research-supported guidance, physicians understandably have questions about whether, when, and how to prescribe opioid analgesics for chronic pain without increasing public health risks. Here, we draw on recent research to address common misconceptions regarding the abuse-related risks of opioid analgesics and highlight strategies to minimize those risks.
Complexity Analysis of Arterial Pressure During Periods of Abrupt Hemodynamic Changes (2008)

In this communication, we estimated the Lempel-Ziv complexity (LZC) on over 40 h of arterial blood pressure (ABP) recordings corresponding to 18 mechanically ventilated animal subjects. In this study, all subjects underwent a period of abrupt hemodynamic changes after an induced injury involving severe blood loss leading to hemorrhagic shock, followed by fluid resuscitation using either lactated ringers or 0.9% normal saline. The LZC metric experienced a statistically significant increase (p < 0.01) immediately following the induced injury and a statistically significant reduction following the administration of fluid therapy (p < 0.01). These results indicate that LZC of ABP may be useful as a dynamic metric to assess fluid responsiveness.
Role of Alcoholic Intermediates in Formation of Isomeric Ketones From <i>n</i> -Hexadecane by a Soil <i>Arthrobacter</i> (1969)

A soil Arthrobacter species isolated from an Oregon soil was capable of transforming n-hexadecane to a series of ketonic products, the 2-,3-, and 4-hexadecanones, with evidence for accumulation of 2- and 3-hexadecanols as oxidative intermediates when yeast extract or peptone was used as a growth substrate. The accumulation and participation of internal alcohols in this type of hydrocarbon transformation has not been previously reported. In the absence of yeast extract or peptone, growth from low-level inocula was not observed when n-hexadecane or two oxidation products, 2-hexadecanol and 3-hexadecanone, were used as substrates. However, washed resting cell suspensions of the organism transformed 2-hexadecanol, or a mixture of 2-,3-, and 4-hexadecanols, to the corresponding ketones without lag, indicating the possible constitutive nature of the alcohol dehydrogenase enzyme(s) carrying out this reaction. The addition of glucose to these resting cells stimulated transformation of n-hexadecane to alcoholic and ketonic oxidation products. Formation of isomeric internal alcohols appears to be a limiting step in ketone formation by this Arthrobacter isolate.
Fabrication of a planar solid oxide fuel cell (2003)

The authors summarize the results of a study on solid oxide fuel cells (SOFCs). Emphasis is placed on the development of new sinterable lanthanum chromite for the separator and the development of a method for fabricating a planar SOFC by the inexpensive tape casting method. It is found that chromium-poor calcium-doped lanthanum chromite can be formed into a dense gas-tight plate by sintering doctor blade films above 1720 K in air. Composite plates are cofired from green foam membranes of distributors and dense green films of electrolyte or separator.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Pharmacodynamic Monitoring of Molecular-Targeted Agents in the Peripheral Blood of Leukemia Patients Using Flow Cytometry (2008)

The introduction of specific, molecular-targeted drugs is radically changing cancer treatment. Pharmacodynamics, which measures drug effects on the host, is key during early-phase clinical trials of novel agents to determine the relations between drug dose and target inhibition as well as measure the downstream effects of target inhibition on the cancer. In this article, we describe the application of flow cytometry to the pharmacodynamic monitoring of molecular-targeted agents in leukemia patients. The methods are based on current clinical flow-cytometry applications, with the addition of phosphospecific antibodies to measure the activation states of intracellular signaling elements and the introduction of techniques that maintain drug-target equilibrium during sample preparation. Using this approach, we successfully showed dose-dependent inhibition of c-Kit during a phase I clinical trial treating acute leukemia patients with the novel agent sorafenib. Further refinements identify considerable interpatient variation in signaling activity within leukemic blast populations, suggesting that an individualized approach to treatment based on flow cytometric monitoring might be advantageous. Improvements in sample turnaround offer the potential to introduce real-time pharmacodynamic monitoring during early-phase clinical trials.
TAK1 Is Recruited to the Tumor Necrosis Factor-α (TNF-α) Receptor 1 Complex in a Receptor-interacting Protein (RIP)-dependent Manner and Cooperates with MEKK3 Leading to NF-κB Activation (2005)

Receptor-interacting protein (RIP) plays a critical role in tumor necrosis factor-alpha (TNF-alpha)-induced IkappaB kinase (IKK) activation and subsequent activation of transcription factor NF-kappaB. However, the molecular mechanism by which RIP mediates TNF-alpha-induced NF-kappaB activation is not completely defined. In this study, we have found that TAK1 is recruited to the TNF-alpha receptor complex in a RIP-dependent manner following the stimulation of TNF-alpha receptor 1 (TNF-R1). Moreover, a forced recruitment of TAK1 to TNF-R1 in the absence of RIP is sufficient to mediate TNF-alpha-induced NF-kappaB activation, indicating that the major function of RIP is to recruit its downstream kinases to the TNF-R1 complex. Interestingly, we also find that TAK1 and MEKK3 form a functional complex, in which TAK1 regulates autophosphorylation of MEKK3. The TAK1-mediated regulation of MEKK3 phosphorylation is dependent on the kinase activity of TAK1. Although TAK1-MEKK3 interaction is not affected by overexpressed TAB1, TAB1 is required for TAK1 activation and subsequent MEKK3 phosphorylation. Together, we conclude that TAK1 is recruited to the TNF-R1 complex via RIP and likely cooperates with MEKK3 to activate NF-kappaB in TNF-alpha signaling.
Low-complexity two-dimensional data encoding for memory inter-cell interference reduction (2012)

Inter-cell coupling interference (ICI) affects capacity, performance, reliability and endurance of semiconductor memories, particularly NAND Flash. Constrained coding of a row of cells has been proposed for ICI mitigation by forbidding data patterns that induce interference above a chosen threshold level. We expand the interference model to two dimensions, and derive the severity function for row-by-row data programming. We propose a two-dimensional interference-constrained coding algorithm, based on adaptive one-dimensional encoding. Adaptation occurs at each encoding step, based on the data in the current row and in the previous one. Similarly, decoding is done in reverse. We explore the capacity bounds with the proposed constraints.
Polycationic triazine-based dendrimers: effect of peripheral groups on transfection efficiency (2009)

A panel of eight, second generation triazine dendrimers differing in the number of amines, guanidines, hydroxyls and aliphatic groups on the periphery was synthesized and assayed for gene transfer in an attempt to correlate the effects of surface functionality on transfection efficiency. The physicochemical and biological properties of the dendrimers and dendriplexes, such as condensation of DNA, size, surface charge and morphology of dendriplexes, toxicity and ultimately transfection efficiency in MeWo cells, were analyzed. The results from an ethidium bromide exclusion assay showed that the complexation efficiency of the dendrimers with DNA is moderately affected by surface groups. Increasing the number of surface amines, reducing the number of surface hydroxyl groups, or replacing the amine moiety with guanidines all help strengthen the complex formed. Results from dynamic light scattering and zeta potential analyses indicate that the smallest particles correlate with complexes that exhibit the highest zeta potentials. Cytotoxicity was low for all compounds, particularly for the G2-5 dendrimer containing alkyl groups on the periphery, indicating the benefit of incorporating such neutral functionality onto the surface of the triazine dendrimers. Within this panel, the highest transfection efficiency was observed for the dendrimers that formed the smallest complexes, suggesting that this physicochemical property is an accurate predictor for determining which dendrimers will show high transfection efficiency.
Deformable Shape Completion with Graph Convolutional Autoencoders (2018)

The availability of affordable and portable depth sensors has made scanning objects and people simpler than ever. However, dealing with occlusions and missing parts is still a significant challenge. The problem of reconstructing a (possibly non-rigidly moving) 3D object from a single or multiple partial scans has received increasing attention in recent years. In this work, we propose a novel learning-based method for the completion of partial shapes. Unlike the majority of existing approaches, our method focuses on objects that can undergo non-rigid deformations. The core of our method is a variational autoencoder with graph convolutional operations that learns a latent space for complete realistic shapes. At inference, we optimize to find the representation in this latent space that best fits the generated shape to the known partial input. The completed shape exhibits a realistic appearance on the unknown part. We show promising results towards the completion of synthetic and real scans of human body and face meshes exhibiting different styles of articulation and partiality.
Big Data Market Optimization Pricing Model Based on Data Quality (2019)

In recent years, data has become a special kind of information commodity and promoted the development of information commodity economy through distribution. With the development of big data, the data market emerged and provided convenience for data transactions. However, the issues of optimal pricing and data quality allocation in the big data market have not been fully studied yet. In this paper, we proposed a big data market pricing model based on data quality. We first analyzed the dimensional indicators that affect data quality, and a linear evaluation model was established. Then, from the perspective of data science, we analyzed the impact of quality level on big data analysis (i.e., machine learning algorithms) and defined the utility function of data quality. The experimental results in real data sets have shown the applicability of the proposed quality utility function. In addition, we formulated the profit maximization problem and gave theoretical analysis. Finally, the data market can maximize profits through the proposed model illustrated with numerical examples.
Adalimumab for the treatment of Crohn&rsquo;s disease (2008)

ADA appears to be effective in inducing and maintain clinical remission in CD, including patients not manageable with IFX. Successive clinical practice and further on going trials will confirm a positive role for ADA as a new anti-TNF treatment in CD. The impact on clinical management or on resources should be more studied.
Granulocyte colony‐stimulating factor and its receptor in acute promyelocytic leukemia (1998)

Expression of granulocyte colony-stimulating factor (G-CSF) receptor (G-CSFR) and in vitro proliferative response to G-CSF were investigated by quantitative immunofluorescence and [3H] thymidine uptake, respectively, in a series of acute myeloid leukemias (AML). The results indicated that G-CSFR was detected at high levels in acute promyelocytic leukemia (APL) cells, in comparison with other types of AML. Moreover, APL cells were also seen to predominantly proliferate in response to G-CSF. Based on these observations, we administered recombinant human G-CSF to a patient with APL in the third relapse that was resistant to both cytotoxic agents and all trans retinoic acid, in an attempt to sensitize the leukemic cells to cell-cycle-dependent agents. Complete remission was achieved. The finding that APL cells are exquisitely responsive to G-CSF supports the view that G-CSF is useful for augmentation of their vulnerability to cell-cycle specific agents. Am. J. Hematol. 58:31–35, 1998. © 1998 Wiley-Liss, Inc.
Integral Probability Metrics and Their Generating Classes of Functions (1997)

We consider probability metrics of the following type: for a class of functions and probability measures P, Q we define A unified study of such integral probability metrics is given. We characterize the maximal class of functions that generates such a metric. Further, we show how some interesting properties of these probability metrics arise directly from conditions on the generating class of functions. The results are illustrated by several examples, including the Kolmogorov metric, the Dudley metric and the stop-loss metric.
Enhancement of the third-order nonlinear optical susceptibility in Si quantum wires (1993)

Recent observation of efficient light emission from porous silicon has attracted much attention and renewed interests in the study of nonlinear optical properties of nanometer-sized quantum systems. In this paper, we study the third-order nonlinear optical susceptibility of semiconductor quantum wires. The quantum wires are taken to be circular columns with a cross section size of \ensuremath{\sim}1 nm. The excitonic effects are taken to be the major electronic excitations. We find that the quantum confinement of the excitons greatly enhances the third-order optical nonlinear susceptibility in a quantum wire. The source of the enhancement is primarily the confinement-induced localization of excitons. The large enhancement of the third-order optical nonlinearity estimated here is consistent with the recent observation of the efficient infrared-up-conversion luminescence in porous silicon.