gebhart/patrepeval huggingface dataset:
A Kentucky Collector: An Interview with W. Hugh Peal (1990)

I Iresulted in the loss of one year of schooling.I think that these two happenings exerted a decisive influence on my whole life, because it, to a very considerable extent, diverted my attention from sports, race horses, and the like, all of which were commoner with my contemporaries, and drove me into what, I suppose, we might call the library.Mr. FARRELL: Did you go to Paducah frequently?Mr. PEAL: No, no.We would occasionally go to Paducah to shop.We would occasionally go to Paducah to the minstrels-Lassus White's minstrels.He was a famous minstrel, well-known through the whole South.They came to Paducah every year, and they were honored guests.Mr. FARRELL: Paducah was the social, the cultural center for you.In that, I mean it wouldn't have been Memphis or Nashville or Louisville?Mr. PEAL: To the extent that there was any cultural center, apart from Paducah itself, it would have been St.Louis.And everybody got to Memphis a few times in his lifetime.Now both Memphis and St. Louis, I think, are considerably closer to Paducah than Louisville.I think, also, it's pretty important to remember that although Western Kentucky has been a bit of a poor relation in the romantic interests of the state, it's a good deal older than Central Kentucky.It was where Marquette and Joliet came through, and the Indian Wars.George Rogers Clark rendezvoused there on his trip to Vincennes, and got a large tract of land which included land later owned by my family.Old Fort Columbus, and, across the river, old Fort Massac, where Aaron Burr had his meetings-and those are all a part of what you might call the interior river life of the United States and sort of an entirely different social background than Central Kentucky.And much more of a continental thinking place.So that it would not occur to us that it was strange if we went to Memphis or New Orleans or St. Louis or even
Applications of Operations Research in the Air Transport Industry (2003)

This paper presents an overview of several important areas of operations research applications in the air transport industry. Specific areas covered are: the various stages of aircraft and crew schedule planning; revenue management, including overbooking and leg-based and network-based seat inventory management; and the planning and operations of aviation infrastructure (airports and air traffic management). For each of these areas, the paper provides a historical perspective on OR contributions, as well as a brief summary of the state of the art. It also identifies some of the main challenges for future research.
Sudden Power-Outage Resilient In-Processor Checkpointing for Energy-Harvesting Nonvolatile Processors (2016)

This paper introduces a sudden power-outage resilient in-processor checkpointing for energy-harvesting nonvolatile processors. In energy harvesting applications, a power supply generated from a renewable power source is unstable that may induce frequent sudden power outages, causing the inconsistency among distributed nonvolatile flip-flops (NVFFs) and hence failure rollbacks in conventional nonvolatile processors. To realize continuous operations upon the frequent sudden power outages, the proposed in-processor checkpointing technique fixes the inconsistency using time-reminding redundant NVFFs (TM-RNVFFs). The TM-RNVFFs store the current and the past few data with the timing information of storing. If several NVFFs fail to store the current data due to the sudden power outages, the proposed in-processor checkpointing technique exploits the timing information to find the common newest state among distributed NVFFs, leading to correct rollbacks to the state with consistency. The sudden power-outage effect is modeled to perform design space explorations at different configurations, such as redundancy and checkpointing period. Nonvolatile ARM Cortex-M0 processors are designed using hybrid 90 nm CMOS and 70 nm magnetic tunnel junction (MTJ) technologies. Based on the design space explorations, the proposed nonvolatile processor achieves a several order-of magnitude reduction in rollback error probability with a power dissipation overhead of 11.6 percent and an area overhead of 52.1 percent in comparison with the conventional nonvolatile processor.
Fair Trade and Standard Setting (2001)

Although Indian trade unionists support the notion of labor rights as human rights, they oppose efforts to incorporate into the World Trade Organization any standards set and controlled by transnational corporations in northern governments. Arbitrary WTO standards can contribute to massive unemployment and would inevitably contribute to protectionism. Instead, the author argues for the need to protect worker rights without the threat of trade sanctions.
The relation between hypocholesterolemia and degree of maturation in acute myeloid leukemia (1990)

Plasma cholesterol concentrations were determined in 83 acute myeloid leukemia patients. Mean plasma cholesterol concentration (+/- S.D.) at the time of diagnosis was 2.91 mmol/L (+/- 1.13). The percentage of AML patients having hypocholesterolemia was 90.4 per cent. The lowest cholesterol levels were observed in the poorly differentiated FAB subtypes of acute myeloid leukaemia: AMyL(M1) and AMoL(M5a). The results showed that the initial hypocholesterolemia in acute myeloid leukemia is significantly related to the degree of both cytological and cytochemical maturation of leukemic blast cells at diagnosis. The degree of maturation at diagnosis has been shown to be related to prognosis in favour of more differentiated subtypes of acute myeloid leukemia. Also, hypocholesterolemia has been shown in several epidemiological studies to be related to an increased mortality from human cancer. Therefore, the degree of maturation may serve as a link between hypocholesterolemia and the increased mortality from human cancer.
Choroidal angiography with indocyanine green dye: absorption and fluorescence techniques. (1992)

The results of choroidal indocyanine green (I.C.G.) angiography by the absorption and fluorescence techniques are compared. Both techniques were done using the same apparatus, a modified fundus camera, an image intensifier coupled to a solid-state video camera and a U Matic video recorder. Both were performed with the same dye dilution in the same patients, at a 24-hour interval. The light source was the unmodified 50 Watt halogen light bulb of the fundus camera. The angiograms obtained by the absorption and the fluorescence techniques refer to the same chorioretinal area and the same angiographic phase. Comparison of all the angiograms shows that I.C.G. fluorescence angiography provides a better resolution of choroidal vascular details than the absorption technique.
Confocal Microscopy Changes in Epithelial and Stromal Thickness up to 7 Years After LASIK and Photorefractive Keratectomy for Myopia (2007)

The early increase in central epithelial thickness after myopic LASIK persists for at least 7 years and is probably the result of epithelial hyperplasia. Central corneal thickness increases during the first year after PRK and remains stable thereafter up to 7 years.
The <i>Trypanosoma cruzi</i> Tc52-Released Protein Induces Human Dendritic Cell Maturation, Signals Via Toll-Like Receptor 2, and Confers Protection Against Lethal Infection (2002)

The intracellular protozoan parasite Trypanosoma cruzi is the etiological agent of Chagas disease. We have recently identified a T. cruzi-released protein related to thiol-disulfide oxidoreductase family, called Tc52, which is crucial for parasite survival and virulence. In vitro, Tc52 in combination with IFN-gamma activates human macrophages. In vivo, active immunization with Tc52 relieves the immunosuppression associated to acute infection and elicits a specific immune response. As dendritic cells (DC) have a central role in the initiation of immune responses, we investigated whether Tc52 may modulate DC activity. We show that Tc52 induces human DC maturation. Tc52-treated immature DC acquire CD83 and CD86 expression, produce inflammatory chemokines (IL-8, monocyte chemoattractant protein-1, and macrophage-inflammatory protein-1 alpha), and present potent costimulatory properties. Tc52 binds to DC by a mechanism with the characteristics of a saturable receptor system and signals via Toll-like receptor 2. While Tc52-mediated signaling involves its reduced glutathione-binding site, another portion of the molecule is involved in Tc52 binding to DC. Finally, we report that immunization with Tc52 protects mice in vivo against lethal infection with T. cruzi. Together these data evidence complex molecular interactions between the T. cruzi-derived molecule, Tc52, and DC, and suggest that Tc52 and related class of proteins might represent a new type of pathogen-associated molecular patterns. Moreover, the immune protection data suggest that Tc52 is among candidate molecules that may be used to design an optimal multicomponent vaccine to control T. cruzi infection.
Joint Channel and Phase Noise Compensation for OFDM in Fast-Fading Multipath Applications (2009)

Orthogonal frequency-division multiplexing (OFDM) systems, such as the new wireless standards or the schemes proposed for third-generation (3G) evolution, exhibit great sensitivity to the effects of phase noise and the time-varying propagation channel, which can introduce interchannel interference (ICI) due to the loss of orthogonality among subcarriers. In this paper, joint channel estimation and ICI reduction schemes are investigated, which compensate the effects of phase noise and multipath channel in a realistic scenario, where the channel is not assumed perfectly known, whereas its estimation is obtained by combining a decision-feedback scheme and a pilot-aided estimator. We propose a technique for ICI compensation that has reduced complexity by only considering the most significant terms of ICI.
Media for Culture of Mammalian Cells (1998)

When mammalian cells are cultured in vitro, the investigator is attempting to reproduce the physiological environment in order to maintain and analyze normal functions and responses. The culture medium is an essential component of the in vitro environment and must be selected or designed with care. This unit provides guidelines for design of serum-containing and serum-free media, selective and specialty media, and media for growth under special conditions such as soft-agar growth.
131I-labeled peptides as caspase substrates for apoptosis imaging. (2005)

It could be demonstrated that peptides consisting of DEVDG and Tat sequence are caspase substrates with enhanced uptake and retention in apoptotic cells. Current efforts are focused on alternative radioisotopes that include radiometal complexes to further improve these characteristics.
Design, synthesis and biological evaluation of C(6)-indole celastrol derivatives as potential antitumor agents (2015)

A new class of C(6)-indole substituted celastrol derivatives were designed and synthesized. Among all these synthesized molecules, compound<bold>4f</bold>and<bold>4h</bold>displayed excellent<italic>in vitro</italic>antiproliferative activities against Bel7402 cancer cells.
Selective Inhibition of HIV Replication by Adriamycin in Macrophages But Not in Lymphocytes (1992)

Adriamycin (ADR) is an anticancer drug commonly used in the treatment of HIV-related cancers. Due to its effect on DNA metabolism, ADR might be able to modulate HIV replication in monocyte-macrophages (M/M), resting cells potentially less sensitive to the toxic effect of this drug. Thus, we assessed the efficacy of ADR against HIV replication in both lymphocytes and M/M. We further investigated the mechanism(s) of action of ADR and its potential synergistic activity with zidovudine (AZT) or alpha-interferon (IFN alpha). ADR consistently inhibited viral replication in M/M: 50% viral inhibition was obtained with 0.005 micrograms/ml ADR, while greater 90% viral inhibition was obtained with 0.05 micrograms/ml ADR. No cell toxicity was seen in M/M at concentrations up to 0.5 micrograms/ml. No anti-HIV activity was shown by ADR in lymphocytes at concentrations up to 0.05 micrograms/ml, that is also the toxic dose 50% (TCID50 for these cells). ADR neither inactivates HIV virions nor affects HIV binding with CD4 receptors. No inhibition of HIV reverse transcriptase by ADR was found at concentrations at least 2,000-fold greater than the 50% HIV inhibitory concentration in M/M. Molecular analysis by polymerase chain reaction (PCR) suggests that ADR substantially affects virus DNA production at concentrations that inhibit viral replication. Finally, late stages of HIV replication were not affected by ADR. At least additive effects of the association ADR + AZT and ADR + IFN alpha were obtained against de novo HIV infection of M/M.(ABSTRACT TRUNCATED AT 250 WORDS)
Hematologic Safety and Tolerability of Topotecan in Recurrent Ovarian Cancer and Small Cell Lung Cancer: An Integrated Analysis (2005)

The purpose was to conduct an integrated analysis of the cumulative hematologic toxicity of topotecan in patients with relapsed ovarian cancer and small cell lung cancer (SCLC). Data were pooled from eight phase II and phase III clinical studies performed in patients with relapsed stage III/IV ovarian cancer or extensive SCLC treated with topotecan at a dose of 1.5 mg/m(2) per day on days 1-5 of a 21-day course. Quantitative hematologic toxicities were assessed using the National Cancer Institute Common Toxicity Criteria. A total of 4,124 courses of therapy was administered to the 879 patients in the pooled population. Grade 4 neutropenia was experienced by 78% of patients. The lowest nadirs for neutrophils and platelets generally occurred after the first course of therapy, followed by improvement or stabilization in subsequent courses. Neutropenia was noncumulative. During the first course, significant risk factors were identified: renal impairment and advanced age (grade 3/4 thrombocytopenia and grade 4 neutropenia) and prior radiotherapy; performance status score > or =2; SCLC; and exposure to both cisplatin (Platinol; Bristol-Myers Squibb, Princeton, NJ, http://www.bms.com) and carboplatin (Paraplatin; Bristol-Myers Squibb) (grade 3/4 thrombocytopenia only). The most frequent interventions for hematologic toxicities were RBC transfusions, treatment delays, G-CSF support, and dose reductions. Analysis of neutrophil and platelet nadirs and dosing for each course of therapy showed no apparent evidence of cumulative neutropenia or thrombocytopenia. The risk of grade 3 or 4 anemia was higher during the first four courses of therapy and may need to be more aggressively managed with erythropoietin therapy.
Global Cost of Corrosion—A Historical Review (2005)

Abstract This article analyzes the estimates of the cost of corrosion, made in various countries at various times. The data are extrapolated to a 2004 base and then projected to the global economy. The chronological order of the countries are the United States of America, the United Kingdom, Australia, Japan, Canada, Germany, Poland, South Africa, Czechoslovakia, Belgium, Netherlands, Sweden, Finland, the Union of Soviet Socialist Republics, Kuwait, India, and the Basque Region.
Investigation of design options for overlaying 40Gb/s coherent PDM-QPSK channels over a 10Gb/s system infrastructure (2008)

To contain limitations from cross nonlinear effects caused by 10Gb/s NRZ channels onto 40Gb/s coherent polarisation division multiplexing quadrature phase shift keying (PDM-QPSK) channels, we investigate the benefits of optimizing the carrier phase estimation process and introducing band-gaps in the multiplex.
Sensing Surrounding 3-D Space for Navigation of the Blind (2008)

This article presents a two-dimensional (2-D) vibration array for detecting dynamic changes in three-dimensional (3-D) space during navigation and provides these changes in real time to visually impaired users (in a form of vibration) to develop a 3-D sensing of the space and assist their navigation in their working and living environment. This vibration array is a part of the Tyflos prototype device (consisting of two tiny cameras, a microphone, an ear speaker mounted into a pair of dark glasses and connected into a portable PC) for blind individuals. The overall idea is of detecting changes in a 3-D space is based on fusing range data and image data captured by the cameras and creating the 3-D representation of the surrounding space. This 3-D representation of the space and its changes are mapped onto a 2-D vibration array placed on the chest of the blind user. The degree of vibration offers a sensing of the 3-D space and its changes to the user. It is concluded that the power conception will be associated with the potential of the batteries of the portable computer (notebook). Thus, the visually impaired user has to recharge the batteries after a certain time or carry additional batteries connected to notebook.
Wideband crosstalk interference cancelling on xDSL using adaptive signal processing and common mode signal (2004)

Crosstalk originating from multiple high-speed data services in the same telephone bundle is a limiting factor for the maximum bit rate, the loop length and the number of data services that a bundle can support. Due to the nature of twisted-pairs, external interferences (including crosstalk) mostly couple to the twisted-pair line in common mode, and then leaks to differential mode due to line imperfect balance. The result is a degradation of the received differential signal quality. This paper uses the common mode signal as a reference to an adaptive wideband crosstalk canceller, as an attempt to remove the effect of crosstalk on the differential signal. Simulation results show the potential benefits of using this technique to reduce the crosstalk levels.
FIPBLOX: a graphical interactive design tool for FIPSOC (2003)

Abstract: FIPSOC is a field programmable mixed-signal integrated device consisting of a Field Programmable Gate Array (FPGA), a set of programmable and interconnectable analog cells, and a microprocessor core which can run general purpose user programs, handle the dynamic reconfiguration of the programmable blocks and probe, in real time, internal digital and analog signals. This device is specially suitable for development and fast prototyping of mixed signal integrated applications. As FIPSOC project is currently under development, it has no yet any powerful tool for synthesis and a structural VHDL (components) approach is to be used for designing. Therefore, the user starts from simple design structures and through a bottom-up style must build more complex components. In this paper we present FIPBLOX, a tool that allows the user automatically generate VHDL code for implementing and customizing high-level modules using the basic resources provided by the FIPSOC FPGA. 1.
Effect of high-&#x03BA;, gate dielectrics on channel engineered deep sub-micrometer n-MOSFET device (2008)

The potential impact of high permittivity gate dielectrics on CON, and tilt angle halo implants of sub 100 nm Lateral Asymmetric Channel (LAC) n-MOSFET's device is studied using Synopsys ISE-TCAD. In this paper, we systematically investigate the effects of the conventional, low (10deg) and high (50deg) tilt angle halo implants with different high-k gate dielectrics values for sub 100 nm lateral asymmetric channel (LAC) MOSFETs with EOT 2.5 nm. The effect in variation of gate dielectric material, on the short channel performance contributing to DIBL, I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">off</sub> , I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">on</sub> , Sub-threshold Swing, and I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ON</sub> /I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">OFF</sub> ratio which are primarily considered as logic performance parameters of the device are studied. The same device has also been looked in for analog performance like trans-conductance (g <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">m</sub> ) and overall gain (g <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">m</sub> R <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> ).
Accurate characterization of the variability in power consumption in modern mobile processors (2012)

The variability in performance and power consumption is slated to grow further with continued scaling of process technologies. While this variability has been studied and modeled before, there is lack of empirical data on its extent, as well as the factors affecting it, especially for modern general purpose microprocessors. Using detailed power measurements we show that the part to part variability for modern processors utilizing the Nehalem microarchitecture is indeed significant. We chose six Core i5-540M laptop processors marketed in the same frequency bins - thus presumed to be identical - and characterized their power consumption for a variety of representative single-threaded and multithreaded application workloads. Our data shows processor power variation ranging from 7%-17% across different applications and configuration options such as Hyper-Threading and Turbo Boost. We present our hypotheses on the underlying causes of this observed power variation and discuss its potential implications.
Tunable Materials from Hydrogen‐Bonded Pseudo Block Copolymers (2005)

Pseudo block copolymers with tunable micro- or macrophase-separated structures are created by introducing multiple hydrogen-bonding groups at the polymer ends (see Figure). The resulting materials are stabilized up to 80 °C above the glass-transition temperature (Tg) of the higher-Tg component. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2089/2005/c1505_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Occupant Classification System for Smart Restraint Systems (1999)

The primary function of an occupant classification (OC) system is to provide reliable passenger seat occupancy information to the automobile's central processing unit to control airbag deployment. This paper highlights an OC sensor system that is based on analysis of the seat occupancy pressure profile, which discerns humanlike from human unlike profiles. If the occupancy is identified as a person, an allocation into one of four morphologic ranges is made. Accordingly, children, light adults, heavy children, medium adults, and heavy adults can all be discerned.