gebhart/patrepeval huggingface dataset:
Efficient beam steering in the 1.55 micron window using large-tilt FLC one-dimensional array (1998)

The recent development of wavelength division multiplexing requires novel transparent optical switches with moderate reconfiguration rates (typically the ms) for management and safety requirements at the optical -wavelength- level. One important fonction in such an optical switch is beam steering in the infrared 1.55 μm region. For that purpose, we propose to design a ferroelectric liquid crystal spatial light modulator (FLC SLM) acting as a programmable diffraction grating. Futhermore, a large-tilt angle FLC is used to make the device insensitive to the polarisation of the input wavefront. Prior to the realisation of the optical swich, we present here an experimental characterisation of the FLC beam deflector.
Synthesis and Characterization of Polyimides Based on 3,6-Diphenylpyromellitic Dianhydride (1989)

3,6-Diphenylpyromellitic dianhydride (DPPMDA) has been synthesized from 2,5-diphenyl-3,4-bis(4-methoxyphenyl)cyclopentadiene-1-one and dimethyl acetylenedicarboxylate. The monomer was polymerized with 11 aromatic diamines in refluxing m-cresol containing isoquinoline to afford two new series of phenylated polyimides. The polymers containing flexible ether or methylene linkages, meta-catenation, or cardo linkages were soluble in m-cresol, N-methylpyrrolidinone, and symtetrachloroethane. Their intrinsic viscosities ranged from 0.81 to 2.40 dl/g. The polymers prepared from 4,4′-diaminodiphenyl ether, 4,4′-diaminodiphenylmethane, and 1,3-diaminobenzene underwent extensive crystallization in concentrated m-cresol solutions. These polymers displayed weak glass-transition temperatures between 310°C and 320°C and melting points near 430°C. Three para-catenated, rigid-rod polymers were also prepared from DPPMDA and substituted 4,4′-diaminobiphenyls that displayed limited solubility in m-cresol. Solutions containing 8.5 to 15% (w/v) of the polymer prepared from 2,2′-bis(trifluoromethyl)-4,4′-diaminobiphenyl underwent reversible gellation near 85°C. Liquid-crystalline spherulites formed in the gels upon standing at ambient temperatures.
Identification of Genes and Proteins Necessary for Catabolism of Acyclic Terpenes and Leucine/Isovalerate in <i>Pseudomonas aeruginosa</i> (2006)

Geranyl-coenzyme A (CoA)-carboxylase (GCase; AtuC/AtuF) and methylcrotonyl-CoA-carboxylase (MCase; LiuB/LiuD) are characteristic enzymes of the catabolic pathway of acyclic terpenes (citronellol and geraniol) and of saturated methyl-branched compounds, such as leucine or isovalerate, respectively. Proteins encoded by two gene clusters (atuABCDEFGH and liuRABCDE) of Pseudomonas aeruginosa PAO1 were essential for acyclic terpene utilization (Atu) and for leucine and isovalerate utilization (Liu), respectively, as revealed by phenotype analysis of 10 insertion mutants, two-dimensional gel electrophoresis, determination of GCase and MCase activities, and Western blot analysis of wild-type and mutant strains. Analysis of the genome sequences of other pseudomonads (P. putida KT2440 and P. fluorescens Pf-5) revealed candidate genes for Liu proteins for both species and candidate genes for Atu proteins in P. fluorescens. This result concurred with the finding that P. fluorescens, but not P. putida, could grow on acyclic terpenes (citronellol and citronellate), while both species were able to utilize leucine and isovalerate. A regulatory gene, atuR, was identified upstream of atuABCDEFGH and negatively regulated expression of the atu gene cluster.
The Human Oncogenic Viruses (1986)

The early, organ-specific diagnosis of malignancy continues to be a major unmet medical need. Clearly the ability to establish an early diagnosis of cancer is dependent upon an intimate knowledge of t
ChemInform Abstract: ′HANTZSCH‐TYPE′ DIHYDROPYRIDINES PART 4, CARBOXYLIC ACIDS (1975)

Abstract Aus den Dihydropyridin‐dicarbonester (I) werden Monohydrolysenprodukte (II) nur zu geringen Anteilen erhalten.
Synthesis of Long and Spinnable Multi-Walled Carbon Nanotubes (2012)

Vertically aligned, ultra-long and spinnable multi-walled carbon nanotubes (MWCNT) have been synthesized by chemical vapor deposition (CVD) method. By optimizing growth parameters we could obtain 2 mm high and spinnable carbon nanotube arrays with a very fast growth rate of 100 μm/min. These are very promising results to further use of carbon nanotubes for fabrication of light and strong composite materials.
Different role of zinc transporter 8 between type 1 diabetes mellitus and type 2 diabetes mellitus (2015)

Diabetes can be simply classified into type 1 diabetes mellitus and type 2 diabetes mellitus. Zinc transporter 8 (ZnT8), a novel islet autoantigen, is specifically expressed in insulin-containing secretory granules of β-cells. Genetic studies show that the genotypes of SLC30A8 can determine either protective or diabetogenic response depending on environmental and lifestyle factors. The ZnT8 protein expression, as well as zinc content in β-cells, was decreased in diabetic mice. Thus, ZnT8 might participate in insulin biosynthesis and release, and subsequently involved deteriorated β-cell function through direct or indirect mechanisms in type 1 diabetes mellitus and type 2 diabetes mellitus. From a clinical feature standpoint, the prevalence of ZnT8A is gradiently increased in type 2 diabetes mellitus, latent autoimmune diabetes in adults and type 1 diabetes mellitus. The frequency and epitopes of ZnT8-specific T cells and cytokine release by ZnT8-specific T cells are also different in diabetic patients and healthy controls. Additionally, the response to ZnT8 administration is also different in type 1 diabetes mellitus and type 2 diabetes mellitus. In the present review, we summarize the literature about clinical aspects of ZnT8 in the pathogenesis of diabetes, and suggest that ZnT8 might play a different role between type 1 diabetes mellitus and type 2 diabetes mellitus.
An activated S6 kinase in extracts from serum- and epidermal growth factor-stimulated Swiss 3T3 cells. (1984)

Soluble extracts from serum- or epidermal growth factor-stimulated Swiss 3T3 cells show up to a 25-fold increase in their ability to phosphorylate 40 S ribosomal protein S6. The increased S6 phosphorylation is due to increased protein kinase activity in extracts of stimulated cells and not due to the inactivation of an S6 phosphatase. However, the presence of phosphatase inhibitors as well as EGTA is required during the preparation of cell extracts to obtain fully active S6 kinase(s). Epidermal growth factor has little effect at concentrations below 10(-10) M: activity increases sharply at 10(-9) M epidermal growth factor and reaches saturation at 10(-8) M (50-60% of the activity obtained by stimulating with 10% serum). Activation of the kinase activity in cell extracts is observed as early as 2 min after serum stimulation, reaches 50% between 10 and 15 min, and is maximal by 60 min of serum stimulation. Phosphorylation in vitro of ribosomal protein S6 with extracts from serum-stimulated cells followed by analysis of the tryptic phosphopeptides shows the presence of 9 of the 11 phosphopeptides induced by serum in vivo.
Coordinated Accumulation of (+)-δ-Cadinene Synthase mRNAs and Gossypol in Developing Seeds of <i>Gossypium hirsutum</i> and a New Member of the <i>cad</i>1 Family from <i>G. arboreum</i> (1998)

A new member of the (+)-delta-cadinene synthase (CAD1) family was isolated from a Gossypium arboreum cDNA library. This cDNA encodes a protein that showed 97.3%, 96.9%, and 79.2% sequence identities with the proteins encoded by previously isolated cDNAs of cad1-C1, cad1-C14, and cad1-A, respectively. It may be grouped into the cad1-C subfamily as cad1-C2. Seeds of a glanded cotton cultivar, G. hirsutum cv. Sumian-6, were collected at different intervals during maturation, and the cad1 mRNA levels were analyzed by quantitative RT-PCR. The transcripts could be detected in seeds of 27 DPA (days postanthesis) and increased dramatically along with the seed maturation, which coordinated with an increase in sesquiterpene cyclase activities and subsequently the accumulation of gossypol. The transcription level detected with primers specific to cad1-C (including at least C1, C14, and cdn1) was higher than that detected with primers specific to cad1-A, and mRNA was detected also with cad1-C2-specific primers. This investigation indicates that, in developing seeds of the glanded cotton cultivar, genes of both the CAD1-C and CAD1-A subfamilies are expressed and there is an active biosynthesis of cadinene-type sesquiterpenes.
Bradykinin B1 and B2 receptors both have protective roles in renal ischemia/reperfusion injury (2007)

To explore the role of the kallikrein-kinin system in relation to ischemia/reperfusion injury in the kidney, we generated mice lacking both the bradykinin B1 and B2 receptor genes (B1RB2R-null, Bdkrb1-/-/Bdkrb2-/-) by deleting the genomic region encoding the two receptors. In 4-month-old mice, blood pressures were not significantly different among B1RB2R-null, B2R-null (Bdkrb2-/-), and WT mice. After 30 min of bilateral renal artery occlusion and 24 h of reperfusion, mortality rates, renal histological and functional changes, 8-hydroxy-2'-deoxyguanosine levels in total DNA, mtDNA deletions, and the number of TUNEL-positive cells in the kidneys increased progressively in the following order (from lowest to highest): WT, B2R-null, and B1RB2R-null mice. Increases in mRNA levels of TGF-beta1, connective tissue growth factor, and endothelin-1 after ischemia/reperfusion injury were also exaggerated in the same order (from lowest to highest): WT, B2R-null, and B1RB2R-null. Thus, both the B1 and B2 bradykinin receptors play an important role in reducing DNA damage, apoptosis, morphological and functional kidney changes, and mortality during renal ischemia/reperfusion injury.
Public Affairs are Your Affairs (1955)

Throughout American history, the trend has been toward giving more and more people the right to vote. But the people seemingly have become less and less interested in voting. Our country has increased in size. Our government and pattern of life have become more complex.
Agro-terrorism and the Grain Handling Systems in Canada and the United States (2004)

The grain handling sector in Canada and the United States is vital to agriculture and trade. In a typical year on the Canadian prairies, about 140,000 producers deliver some 20 to 30 mmt of grain for export to primary elevators. In the United States, about 2.1 million producers deliver about 300 mmt of grain to primary elevators. Canadian grain is moved to export position using more than 400,000 hopper cars and marine containers, where about 1,200 ships per year are loaded. In the United States, about 1.08 million rail carloads of grain are originated per year, and about 23 mmt of grain are shipped on barges per year. These U.S. figures are in addition to trucks, which, more so than in Canada, are also used to deliver grain to primary processors and to terminal and export markets. The volume of grain trade gives rise to concern about risks of terrorism in the sector.(1) From a security perspective, the grain, pulse and oilseed supply chain is noteworthy because much of it is characterized by relatively long-term, insecure, bulky storage (particularly on farms) along with numerous modal and inter-modal product transfers. These factors suggest there are many places where chemical or biological contaminants could be introduced into this supply chain. From the perspective of the United States, security throughout the Canadian system as well as the U.S. system is a concern, since cross-border traffic in these products is significant, with an average of about six million tonnes of grain products alone imported into the U.S. each year (USDA-FAS, 2003). Numerous interventions to enhance food safety and mitigate the risk of terrorism have been adopted or are in the process of being developed. Some of these are private initiatives and voluntary, as a component of firm-level security processes. Others are being adopted in response to legislated initiatives. The stakes are large, and there are likely to be substantial differences in costs and effectiveness of different approaches.
Introducing New Priority Setting and Resource Allocation Processes in a Canadian Healthcare Organization: A Case Study Analysis Informed by Multiple Streams Theory (2015)

Understanding in a theoretically-informed way how change occurs in healthcare management practices can provide useful lessons to researchers and decision-makers whose aim is to help health systems achieve the most effective use of available financial resources.
Parameter Analysis of Chemical Mechanical Polishing: An Investigation Based on the Pattern Planarization Model (1999)

Based on the pattern planarization model, polishing time, polished thickness, and the planarization efficiency of a point of interest on a wafer during the chemical mechanical process are expressed as functions of polishing parameters. The influences as well as the variation of polishing time, polished thickness, and planarization efficiency across the wafer are also presented. The effects of polishing on the process are discussed and the predicted trends in adjusting these polishing parameters are illustrated. © 1999 The Electrochemical Society. All rights reserved.
Endothelin and Other Mediators in the Pathophysiology of Portal Hypertension (1998)

Hyperdynamic circulation as well as increased hepatic resistance contribute to portal hypertension in cirrhosis of the liver [1]. Hyperdynamic circulation with increased cardiac output, heart rate and plasma volume and decreased arterial blood pressure and systemic <i>vasodilatation</i> is pivotal for the hyperdynamic circulation. This has prompted intense research of a number of endogenous neurohumoral mediators with vasodilating properties (NO, natriuretic peptides, glucagon, etc.) [2, 3].
FPGA controlled artificial vascular system (2015)

Abstract Monitoring the oxygen saturation of an unborn child is an invasive procedure, so far. Transabdominal fetal pulse oximetry is a promising method under research, used to estimate the oxygen saturation of a fetus noninvasively. Due to the nature of the method, the fetal information needs to be extracted from a mixed signal. To properly evaluate signal processing algorithms, a phantom modeling fetal and maternal blood circuits and tissue layers is necessary. This paper presents an improved hardware concept for an artificial vascular system, utilizing an FPGA based CompactRIO System from National Instruments. The experimental model to simulate the maternal and fetal blood pressure curve consists of two identical hydraulic circuits. Each of these circuits consists of a pre-pressure system and an artificial vascular system. Pulse curves are generated by proportional valves, separating these two systems. The dilation of the fetal and maternal artificial vessels in tissue substitutes is measured by transmissive and reflective photoplethysmography. The measurement results from the pressure sensors and the transmissive optical sensors are visualized to show the functionality of the pulse generating systems. The trigger frequency for the maternal valve was set to 1 per second, the fetal valve was actuated at 0.7 per second for validation. The reflective curve, capturing pulsations of the fetal and maternal circuit, was obtained with a high power LED (905 nm) as light source. The results show that the system generates pulse curves, similar to its physiological equivalent. Further, the acquired reflective optical signal is modulated by the alternating diameter of the tubes of both circuits, allowing for tests of signal processing algorithms.
Nerve Growth Factor and Transforming Growth Factor-β Serum Levels in Acute Stroke Patients (2001)

Although no significant differences between the two groups were demonstrated, in stroke patients, serum neurotrophins were significantly associated with clinical and neuroradiological parameters of brain injury and positively correlated with each other in the acute phases of stroke, suggesting that stroke may modulate peripheral neurotrophin levels.
Leak detection in an experimental heat exchanger process: a multiple model approach (1991)

An application of a multiple model nonlinear filtering technique is discussed for the detection of leaks in a heat-exchanger process. The results of simulation study and an experimental study on a laboratory heat-exchanger process are presented. A simple decision logic scheme (threshold crossing) is used to process the outputs of the leak-detection algorithm to indicate the status of the process, i.e. whether or not there is a leak. The results of the study provide preliminary indication of the feasibility of the proposed diagnostic technique to detect small leaks in an experimental heat-exchanger process. The study also indicates that the technique is robust in the midst of significant flow disturbances on the inlet water flow, using only simple models for processing of the outlet temperature data, but is sensitive to the aggregate heat transfer parameter used in the detection algorithm.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Image analysis and image processing as tools to measure initial rates of enzyme reactions in sections: distribution patterns of glutamate dehydrogenase activity in rat liver lobules. (1995)

To analyze regional differences in the activity of glutamate dehydrogenase in rat liver in situ, we developed an image recording and processing system for monitoring the formation of a colored final reaction product in time. All absorbance measurements of test and control reactions in time in consecutive sections were used to fit the data to a quadratic curve, with the derivative at t = 0 representing the initial velocity of formazan formation. The images of sections incubated for test and control reactions were topographically matched with an affine transformation using the positions of vessels as fiducials. Specific enzyme activity was calculated by subtracting the coefficients representing the initial velocity at corresponding locations in the test and control reactions and appeared to be 8 and 4 mumoles glutamate converted per min per cm3 of tissue at 20 degrees C in pericentral and periportal zones of fasted female rats, respectively. Those values are in agreement with biochemical data. The ability to construct two-dimensional images of cellular distribution patterns of enzyme activity in liver lobules is particularly useful for the study of metabolic zonation in this organ.
Molecular Comparison of <i>Mycobacterium avium</i> Isolates from Clinical and Environmental Sources (2008)

We collected Mycobacterium avium isolates from clinical and drinking-water sources and compared isolates among themselves and to each other using molecular methods. Four clinical isolates were related to water isolates. Groups of indistinguishable clinical isolates were identified. The groups of identical clinical isolates suggest a common source of exposure.
PTEN Loss Mediates Clinical Cross-Resistance to CDK4/6 and PI3Kα Inhibitors in Breast Cancer (2019)

The combination of CDK4/6 inhibitors with antiestrogen therapies significantly improves clinical outcomes in ER-positive advanced breast cancer. To identify mechanisms of acquired resistance, we analyzed serial biopsies and rapid autopsies from patients treated with the combination of the CDK4/6 inhibitor ribociclib with letrozole. This study revealed that some resistant tumors acquired RB loss, whereas other tumors lost PTEN expression at the time of progression. In breast cancer cells, ablation of <i>PTEN</i>, through increased AKT activation, was sufficient to promote resistance to CDK4/6 inhibition <i>in vitro</i> and <i>in vivo</i>. Mechanistically, <i>PTEN</i> loss resulted in exclusion of p27 from the nucleus, leading to increased activation of both CDK4 and CDK2. Because <i>PTEN</i> loss also causes resistance to PI3Kα inhibitors, currently approved in the post-CDK4/6 setting, these findings provide critical insight into how this single genetic event may cause clinical cross-resistance to multiple targeted therapies in the same patient, with implications for optimal treatment-sequencing strategies. SIGNIFICANCE: Our analysis of serial biopsies uncovered RB and PTEN loss as mechanisms of acquired resistance to CDK4/6 inhibitors, utilized as first-line treatment for ER-positive advanced breast cancer. Importantly, these findings have near-term clinical relevance because <i>PTEN</i> loss also limits the efficacy of PI3Kα inhibitors currently approved in the post-CDK4/6 setting.<i>This article is highlighted in the In This Issue feature, p. 1</i>.
Kalman filter based synchronization methods (2006)

This paper proposes single and three-phase synchronization methods based on the optimum filtering theory. The proposed methods incorporate, explicitly, in the problem formulation the presence of harmonics, voltage unbalance, measurement noise, transients and frequency variation, which can degrade the performance of many synchronization methods. The solution is based on the Kalman filter. Experimental results using a DSP TMS320F2812 are presented to show the performance of the proposed schemes.
Signal Transducers and Activators of Transcription-3 Binding to the Fibroblast Growth Factor Receptor Is Activated by Receptor Amplification (2010)

Fibroblast growth factor receptors (FGFR) are cell surface tyrosine kinases that function in cell proliferation and differentiation. Aberrant FGFR signaling occurs in diverse cancers due to gene amplification, but the associated oncogenic mechanisms are poorly understood. Using a proteomics approach, we identified signal transducers and activators of transcription-3 (STAT3) as a receptor-binding partner that is mediated by Tyr(677) phosphorylation on FGFR. Binding to activated FGFR was essential for subsequent tyrosine phosphorylation and nuclear translocation of STAT3, along with activation of its downstream target genes. Tyrosine phosphorylation of STAT3 was also dependent on concomitant FGFR-dependent activity of SRC and JAK kinases. Lastly, tyrosine (but not serine) phosphorylation of STAT3 required amplified FGFR protein expression, generated either by enforced overexpression or as associated with gene amplification in cancer cells. Our findings show that amplified FGFR expression engages the STAT3 pathway, and they suggest therapeutic strategies to attack FGFR-overexpressing cancers.
Integrating heterogeneous adaptation techniques to build a flexible and usable mobile tourist guide (2006)

Intelligent adaptation is a key issue for the design of flexible support systems for mobile users. In this paper we present UbiquiTO, a tourist guide which integrates different forms of adaptation: (i) to the device used (web access via Laptop, PDA, smartphone), (ii) to the user and her features and preferences (personalized interaction), (iii) to the context of interaction, and in particular to the user location, besides some other features such as the time of the day. UbiquiTO adapts the content of the service being provided (recommendation and amount/type of information/features associated with each recommendation) and the presentation (interface). In order to achieve better performance it keeps track of the user behavior, updating and refining the user model during the interaction. In the paper we introduce the architecture of the system and the choices we made as regards user, device and context modeling and adaptation strategies. We also present the results of a preliminary evaluation of the system behavior.