gebhart/patrepeval huggingface dataset:
Regression of epithelial cancers in humans following t-cell receptor gene therapy targeting human papillomavirus-16 E7. (2018)

3043 Background: Adoptive T-cell therapy with gene-engineered T cells is an emerging cancer treatment strategy. Study of this approach in epithelial cancers, the most common types of malignancies, has been limited. We initiated a clinical trial of gene-engineered T cells that target human papillomavirus (HPV)-16-E7 for the treatment of patients with metastatic HPV-16+ cancers. Methods: The clinical trial was designed as a phase I study with three dose levels (DL) of gene-engineered T cells (DL1: 1 x 109, DL2: 1 x 1010, DL3: 1 x 1011). Patients had metastatic HPV-16+ cancers from any primary tumor site. Patients received a single infusion of autologous T cells that were gene-engineered to express an HLA-A*02:01-restricted T-cell receptor that targets HPV-16 E7 (E7 T cells). A lymphocyte-depleting conditioning regimen was administered before treatment. E7 T cell infusion was followed by high-dose systemic aldesleukin. We report the early results of the ongoing study. Results: Eight patients were treated. No dose-limiting toxicity, off-target T-cell toxicity, or cytokine-release syndrome occurred. Objective clinical responses were observed in 3/7 evaluable patients. Responses occurred in patients with vulvar, oropharyngeal, and anal cancer. Two of these patients had been previously treated with anti-PD-1 checkpoint blockade. One response occurred at DL1. The patient had extensive metastatic vulvar cancer involving the lungs, retroperitoneum, pelvis, and thigh. She had been previously treated with seven systemic anti-cancer agents. The response lasted 8 months after treatment. Two responses occurred at DL2. One was in a patient with metastatic anal cancer with lung, pleura, and kidney tumors. The response is ongoing after 7 months. In the initial six patients, the E7 TCR was expressed by 90-99% of the infused T cells, and E7 T cells were detectable in the peripheral blood six weeks following treatment (1% to 4% at DL1, 5% to 45% at DL2). Conclusions: Tumor regression can occur following treatment of an epithelial cancer with gene-engineered T cells. These findings support continued study of E7 T cells and possibly other types of gene-engineered T cells in epithelial cancers. Clinical trial information: NCI-16-C-0154.
Concealment of lost speech packets using adaptive packetization (2002)

Long-term correlation within a speech signal is usually exploited to achieve higher compression ratios (e.g. RPE-LTP coders). We aim to use the long-term correlation to influence the packetization interval of a voice stream at the sender before sending it over a lossy packet-switched network. If a packet is lost, the receiver can conceal the loss of information by using adjacent signal segments of which (due to the pre-processing/packetization at the sender) a certain similarity to the lost segment can be assumed. Subjective test results show that the adaptive packetization/concealment scheme (AP/C) can alleviate significantly the impact of isolated packet losses to speech quality.
Cognitive Patterns: Problem-Solving Frameworks for Object Technology (1998)

Part I. Introduction to Cognitive Patterns and KADS Object: 1. Introduction to cognitive patterns 2. Introduction to KADS Object Part II. KADS Object Model Development: 3. Knowledge elicitation techniques for cognitive models 4. Mapping cognitive patterns to objects 5. Other uses of KADS Object Part III. Applied Cognitive Patterns: Best-practice Models and Case Study: 6. Best practice: technical architecture 7. Best-practice reuse 8. Best practice: testing OO systems 9. Case study: a retail banking example Appendix A. Library of problem-solving templates Appendix B. Definitions of selected PST operations Glossary.
The prevention of autolysis in stored corneas by lysosome stabilization. A histochemical study. (1977)

We wished to determine if dexamethasome, acting as a lysosome stabilizer, could reduce the release and activation of the lysosomal acid hydrolases, and thus retard autolysis of stored corneas. One cornea (experimental) of a rabbit was soaked in a 2 per cent steroid solution and the other cornea (control) in physiological saline for 3 hours at 23 degrees C. The experimental and control corneas were then processed histochemically to show the localization of the lysosomal marker enzymes beta-glucuronidase and acid phosphatase. Compared to the controls the steroid treated corneas showed reduced enzyme activity suggesting that autolysis during storage had been retarded.
Design and implementation of policy decision point in policy-based network (2005)

As users of network have become increasing, the supply of network-based services has activated and the necessity of a solution considering scale and speed of network for providing network-based services efficiently for users has been generated. A great deal of attention has been given recently to the concepts of the PBNM (policy-based network management) to accomplish these needs. This paper describes design and implementation of PDP (policy decision point) in a policy-based network management system. The PDP provides role-based policy decision and distribution mechanisms. The role-based policy decision and distribution mechanisms allow an administrator manage and transmit policies by roles of devices without configuring each one of network devices manually. So, it provides the administrator with the convenience.
Isolation and Amino Acid Composition of the Isotypes of a Rat Clara Cell Specific Protein (1987)

A protein of molecular weight about 10,000 (Clara cell protein C) present in lung lavage fluid and specific to Clara cells has been shown to have three isotypes. The isotypes have been individually isolated and purified by a combination of molecular sieving, ion exchange chromatography, column chromatofocusing, and reverse phase chromatography. The protein was monitored by immunoblotting and its purity tested by silver staining of the gel following sodium dodecyl sulfate-polyacrylamide gel electrophoresis. About 33.7% of the 10-kDa protein present in starting rat lavage was recovered in final pure preparation. The 10-kDa Clara cell protein amounted to 0.38% of the total protein in rat lung lavage fluid. The three isotypes were present in a ratio of 1.0:2.8:8.8, the amounts increasing with decreasing pI. None of the isotypes bound to concanavalin A. The amino acid compositions of the three isotypes were similar and were remarkable in that the contents of leucine, glutamic acid, aspartic acid, serine, and proline were high, tyrosine was present in low amounts, and methionine and histidine were absent.
Magnetic Anisotropic Effect as Demonstrated by High Resolution PMR in Some Benzoxazinones, Quinazolinones and Their Thiono Analogues (1987)

Abstract A number of 3,1-benzoxazin-4-ones and 4(3H)-quinazollnones and their thiono analogues were recorded with high resolution 1H NMR 400 MHz spectrometer. The magnetic anisotropic effect of (C[dbnd]O) and (C[dbnd]S) groups was also discussed. The study of 1H NMR chemical shift correlated to 2-D PHR allowed the complete assignment of such structure. The introduction of sulphur atom has influenced remarkably the chemical shift of H5 of the benzeniod moiety as well as the chemical shift of the two ortho protons of the phenyl group.
Synthesis and Evaluation of (Piperidinomethylene)bis(phosphonic acid) Derivatives as Anti-osteoporosis Agents. (1993)

Some (piperidinomethylene)bis(phosphonic acid) derivatives were prepared and their activity to inhibit a rise in serum calcium induced by parathyroid hormone in thyroparathyroidectomised rats was evaluated. Several (4-alkylidene-, 4,4-dialkyl-, or 4-alkyl-4-halopiperidinomethylene)bis(phosphonic acid) derivatives showed considerable inhibitory activity. But compounds having aromatic and polar substituents such as azido, hydroxy, amino and amido on the piperidine ring were generally inactive. In this study, two 4-alkylidene compounds (8a and 8b) and a 4,4-cyclic dialkyl compound (61) showed potent activity when administered either intravenously or perorally.
Lignicolous freshwater Ascomycota from Thailand: 1. Ascotaiwania sawada and its anamorph state Monotosporella (1998)

Single ascospore isolates of Ascotaiwania sawada gave rise to conidia of a Monotosporella species. Repeated isolations confirmed that the Monotosporella was the anamorph of A. sawada. These findings are discussed and compared with the other known anamorph-teleomorph stages of freshwater fungi. This species of Monotosporella is new to science but because it has not been found in nature it is referred to as the Monotosporella state of A. sawada.
Actin polymerisation at the cytoplasmic face of eukaryotic nuclei (2006)

We conclude that actin polymerisation occurs around interphase nuclei of living cells at the cytoplasmic phase of NE-membranes.
Incentive Mechanisms for Crowdsensing: Crowdsourcing With Smartphones (2015)

Smartphones are programmable and equipped with a set of cheap but powerful embedded sensors, such as accelerometer, digital compass, gyroscope, GPS, microphone, and camera. These sensors can collectively monitor a diverse range of human activities and the surrounding environment. Crowdsensing is a new paradigm which takes advantage of the pervasive smartphones to sense, collect, and analyze data beyond the scale of what was previously possible. With the crowdsensing system, a crowdsourcer can recruit smartphone users to provide sensing service. Existing crowdsensing applications and systems lack good incentive mechanisms that can attract more user participation. To address this issue, we design incentive mechanisms for crowdsensing. We consider two system models: the crowdsourcer-centric model where the crowdsourcer provides a reward shared by participating users, and the user-centric model where users have more control over the payment they will receive. For the crowdsourcer-centric model, we design an incentive mechanism using a Stackelberg game, where the crowdsourcer is the leader while the users are the followers. We show how to compute the unique Stackelberg Equilibrium, at which the utility of the crowdsourcer is maximized, and none of the users can improve its utility by unilaterally deviating from its current strategy. For the user-centric model, we design an auction-based incentive mechanism, which is computationally efficient, individually rational, profitable, and truthful. Through extensive simulations, we evaluate the performance and validate the theoretical properties of our incentive mechanisms.
Extensible Video Processing Framework in Apache Hadoop (2013)

Digital video is prominent big data spread all over the Internet. It is large not only in size but also in required processing power to extract useful information. Fast processing of excessive video reels is essential on criminal investigations, such as terrorism. This demo presents an extensible video processing framework in Apache Hadoop to parallelize video processing tasks in a cloud environment. Except for video transcending systems, there have been few systems that can perform various video processing in cloud computing environments. The framework employs FFmpeg for a video coder, and OpenCV for a image processing engine. To optimize the performance, it exploits MapReduce implementation details to minimize video image copy. Moreover, FFmpeg source code was modified and extended, to access and exchange essential data and information with Hadoop, effectively. A face tracking system was implemented on top of the framework for the demo, which traces the continuous face movements in a sequence of video frames. Since the system provides a web-based interface, people can try the system on site. In an 8-core environment with two quad-core systems, the system shows 75% of scalability.
Therapy for lysosomal storage disorders (2009)

In the last years, much progress has been achieved in the field of lysosomal storage disorders. In the past, no specific treatment was available for the affected patients; management mainly consisted of supportive care and treatment of complications. As orphan drug regulations, however, encouraged development of drugs for these disorders by granting marketing exclusivity for 10 years and other commercial benefits, enzyme replacement therapy became available for lysosomal storage disorders, such as Gaucher disease, Fabry disease, mucopolysaccharidoses type I, II, and VI, and Pompe disease. This review will summarize the efficacy and clinical status of hematopoietic stem cell transplantation, enzyme replacement, and substrate deprivation therapy, and describe new therapeutic perspectives currently under preclinical investigations such as chaperone-mediated therapy, stop-codon read-through therapy, and gene therapy.
Chemotherapy using intra-arterial infusion for oral cancer. (2006)

There are three historically recognized methods of intra-arterial infusion for oral cancer: Conventional intra-arterial infusion via the superficial temporal artery: Superselective intra-arterial infusion via the femoral artery (Seldinger method), New superselective intra-arterial infusion via the superficial temporal artery. Here we report a recent instance of daily concurrent chemoradiotherapy using a new superselective intra-arterial infusion. A catheter with a curved tip was inserted superselectively into the feeding artery of the tumor via the superficial temporal artery (long-term catheterization has become possible using this method). The patient with T3 tongue cancer was treated by chemoradiotherapy. Radiotherapy (total dose: 40 Gy/4weeks) and superselective intra-arterial infusion chemotherapy using docetaxel (DOC) (total dose: 60 mg/m2/4weeks, 15 mg/m2/week) and cisplatin (CDDP) (total dose: 100 mg/m2/4weeks, 5 mg/m2/day) were concurrently performed daily, followed by surgery, after which no major complication was observed. The clinical effect was complete response (CR), and the pathological effect on the resected tumor after surgery was pathological CR. This method promises to be a new strategy of choice for the treatment of oral cancer.
DSP in mammography (2003)

Breast cancer is the most frequently occurring cancer in females with no cure at present. Early detection offers the best chance of survival and mammography is used to screen the asymptomatic female population above fifty years of age. Computerized analysis of mammograms can assist radiologists to detect lesions or abnormalities. However, the entire digitized mammogram must first be segmented and analyzed prior to lesion detection. This paper summarizes work done at the Australian Research Centre for Medical Engineering (ARCME) to systematically and hierarchically segment mammograms as a precursor to lesion detection. The breast is first segmented from the non-breast background by polynomial modelling and subtraction of the latter region. The nipple, which is the only anatomical landmark, is then located using a sensitive feature set to search the breast border. The pectoral muscle is then identified by an adaptive edge detection/surface fitting algorithm. Finally, a systematic methodology is proposed for lesion search.
Survey of the Free and Conjugated Myricetin and Quercetin Content of Red Wines of Different Geographical Origins (1998)

Gradient reversed-phase HPLC was used to obtain quantitative estimates of the levels of free and conjugated myricetin and quercetin in 65 red wines from Italy, Chile, France, California, Australia, Bulgaria, Spain, Romania, New Zealand, Brazil, Morocco, and Hungary. The concentrations of total flavonols ranged from 4.6 to 41.6 mg L(-1). High total flavonol levels appear to be associated with the use of thick-skinned grape varieties, such as Cabernet Sauvignon, with a high skin:volume ratio, which were left to ripen fully in sunny conditions before harvest and which were extracted efficiently by modern methods of vinification. Some Chilean Cabernet Sauvignon wines contained up to 40 mg of total flavonols L(-1), which was higher than the levels detected in Cabernet Sauvignon from France, California, and Australia. The flavonol content of 1989 and 1990 Cabernet Sauvignon from Bulgaria was <6 mg L(-1). Chilean Cabernet Sauvignon, Merlot, and Pinot Noir all contained consistently higher concentrations of flavonols than their counterparts from different geographical regions.
Model-based Segmentation of 3D Point Clouds for Phenotyping Sunflower Plants (2017)

International audience
A Soviet Study of the American Position in the Far East (1936)

AN IMPORTANT Soviet contribution to the study of Pacific problems has been made by A. Kantorovich in his book America v Borbe za Kitai (America in the Struggle for China). This book was reviewed in the March I936 number of PACIFIC AFFAIRS and is now being translated by the American Council of the Institute of Pacific Relations. Kantorovich bases his study on wide documentary sources, including some previously unpublished materials from the Tsarist archives. He likewise includes copious references to newspaper and periodical sources on the whole period of American relations with the Far East. The concluding chapters of the book give an analysis of the contemporary international situation in the Pacific. This aspect of the study has been expanded by the author in a series of articles appearing in Soviet publications; the most important of these are:
Novel intrinsic and extrinsic engineering for high-performance high-density self-aligned InGaAs MOSFETs: Precise channel thickness control and sub-40-nm metal contacts (2014)

We have fabricated self-aligned tight-pitch InGaAs Quantum-well MOSFETs (QW-MOSFETs) with scaled channel thickness (t <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</sub> ) and metal contact length (L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</sub> ) by a novel fabrication process that features precise dimensional control. Impact of t <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</sub> scaling on transport, resistance and short channel effects (SCE) has been studied. A thick channel is favorable for transport, and a mobility of 8800 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> /V·s is obtained with t <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</sub> =11 nm at N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">s</sub> =2.6×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">12</sup> cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-2</sup> . Also, a record g <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">m,max</sub> of 3.1 mS/μm and R <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">on</sub> of 190 Ω·μm are obtained in MOSFETs with t <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</sub> =9 nm and gate length L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">g</sub> =80 nm. In contrast, a thin channel is beneficial for SCE control. In a device with t <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</sub> =4 nm and L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">g</sub> =80 nm, S is 111 mV/dec at V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ds</sub> = 0.5 V. For the first time, working front-end device structures with 40 nm long contacts and gate-to-gate pitch of 150 nm are demonstrated. A new method to study the resistance properties of nanoscale contacts is proposed. We derive a specific contact resistivity between the Mo contact metal and the n <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+</sup> InGaAs cap of ρ=(8±2)×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-9</sup> Ω·cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . We also infer a metal-to-channel resistance of 70 Ω·μm for 40 nm long contacts.
Chemical, photochemical and spectroscopic characterization of an alkaline proteinase from <i>Bacillus subtilis</i> variant DY (1982)

Circular-dichroism and fluorescence studies indicate that the 5-dimethylaminonaphthalene-1-sulphonyl and phenylmethanesulphonyl derivatives of subtilisin DY have three-dimensional structure closely similar to that of native enzyme. The single tryptophan residue is largely accessible to the aqueous solvent, and is not directly involved in the enzyme-substrate interactions, since its photochemical modification causes only a partial inhibition of the enzyme activity. It appears very likely that the location of the single tryptophan residue in the three-dimensional structure of subtilisin DY is similar to that of the single tryptophan residue in subtilisin Carlsberg. Fluorescence-quenching experiments further indicate that the 14 tyrosine residues are also largely accessible to the aqueous solvent, and probably interact with hydrated peptide carbonyl groups. The charge environment for tryptophan and tyrosine residues in subtilisin DY, as deduced by quenching experiments with ionic species, is also discussed. In general, subtilisin DY displays strong similarities to subtilisin Carlsberg, as suggested by a comparative analysis of the amino acid composition and fluorescence properties.
Glutamatergic Innervation of the Heart Initiates Retrograde Contractions in Adult<i>Drosophila melanogaster</i> (2005)

The adult abdominal heart of Drosophila melanogaster receives extensive innervation from glutamatergic neurons at specific cardiac regions during metamorphosis. Here, we show that the neurons form presynaptic specializations, as indicated by the localization of synaptotagmin and active zone markers, adjacent to postsynaptic sites that have aggregates of glutamate IIA receptors. To determine the role of this innervation in cardiac function, we developed an optical technique, based on the movement of green fluorescent protein-labeled nerve terminals, to monitor heart beat in intact and semi-intact preparations. Simultaneous monitoring of adjacent cardiac chambers revealed the direction of contractions and allowed correlation with volume changes. The cardiac cycle is composed of an anterograde beat in alternation with a retrograde beat, which correlate respectively with systole and diastole of this multichambered heart. The periodic change in hemolymph direction is referred to as cardiac reversal. Intracellular recordings from muscles of the first abdominal cardiac chamber, the conical chamber, revealed pacemaker action potentials and the excitatory effect of local glutamate application, which initiated retrograde contractions in semi-intact preparations. Unilateral electrical stimulation of the transverse nerve containing the glutamatergic neuron that serves the conical chamber caused a chronotropic effect and initiation of retrograde contractions. This effect is distinct from that of peripheral crustacean cardioactive peptide (CCAP) neurons, which potentiate the anterograde beat. Cardiac reversal was evoked pharmacologically by sequentially applying CCAP and glutamate to the heart.