gebhart/patrepeval huggingface dataset:
Minimizing concurrent test time in SoC's by balancing resource usage (2002)

We present a novel test scheduling algorithm for embedded core-based SoC's. Given a system integrated with a set of cores and a set of test resources, we select a test for each core from a set of alternative test sets, and schedule it in a way that evenly balances the resource usage, and ultimately reduce the test application time. Furthermore, we propose a novel approach that groups the cores and assigns higher priority to those with smaller number of alternate test sets. In addition, we also extend the algorithm to allow multiple test sets selection from a set of alternatives to facilitate testing for various fault models.
Detector for phosphine at permissible levels in air (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetector for phosphine at permissible levels in airMysore Muthu, Suvendu K. Majumder, and Husain A. B. ParpiaCite this: J. Agric. Food Chem. 1973, 21, 2, 184–186Publication Date (Print):March 1, 1973Publication History Published online1 May 2002Published inissue 1 March 1973https://pubs.acs.org/doi/10.1021/jf60186a010https://doi.org/10.1021/jf60186a010research-articleACS PublicationsRequest reuse permissionsArticle Views52Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Growth inhibitory effects of celecoxib in human umbilical vein endothelial cells are mediated through G1 arrest via multiple signaling mechanisms (2004)

Evidence suggests that the angiogenic endothelium represents an important target through which celecoxib mediates in vivo antitumor effects. Nevertheless, the pharmacologic basis for celecoxib-caused growth inhibition in endothelial cells in vitro remains to be defined. Previously, we showed that celecoxib-induced apoptosis in PC-3 prostate cancer cells was mediated in part through the inhibition of 3-phosphoinositide-dependent kinase-1/Akt signaling. Our present findings show that celecoxib inhibits the growth of human umbilical vein endothelial cells (HUVEC) with pharmacologic profiles reminiscent of those of PC-3 cells. The underlying antiproliferative mechanism, however, may differ between these two cell types considering differences in the functional status of many tumor suppressors, including PTEN, p53, and retinoblastoma, all of which play integral roles in regulating cell cycle progression and survival. From a mechanistic perspective, the genomic integrity of the HUVEC system presents a vastly different intracellular context to examine how celecoxib acts to induce growth inhibition. Here, we obtain evidence that the antiproliferative effects of celecoxib and its close, cyclooxygenase-2-inactive analogue 4-[5-(2,5-dimethylphenyl)-3(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (DMC) in HUVECs at pharmacologically attainable concentrations (10-20 micromol/L) are attributable to the inhibition of phosphoinositide-dependent kinase-1/Akt signaling and cyclin-dependent kinase. Especially, celecoxib- and DMC-mediated G1 arrest is associated with attenuated retinoblastoma phosphorylation through the inhibition of multiple cyclin-dependent kinases (IC50, 10-35 micromol/L). Moreover, both celecoxib and DMC reduce neovascularization in the chicken chorioallantoic membrane assay, suggesting the involvement of a cyclooxygenase-2-independent mechanism in the in vivo antiangiogenic effects of celecoxib.
Strategies for improved isopropanol–butanol production by a Clostridium strain from glucose and hemicellulose through consolidated bioprocessing (2017)

The co-production of isopropanol with butanol by the newly isolated <i>Clostridium</i> sp. strain NJP7 would add on the economical values for butanol fermentation. Furthermore, the high isopropanol-butanol production with in situ extraction would also greatly enhance the economic feasibility for fermentative production of butanol-isopropanol in large scale. Meanwhile, its direct production of butanol-isopropanol from polysaccharides, hemicellulose through secretion of indigenous thermostable xylanase, shows great potential using lignocellulosic wastes for biofuel production.
Stochastic Parse Tree Selection for an Existing RBMT System (2011)

In this paper we describe our hybrid machine translation system with which we participated in the WMT11 shared translation task for the English→German language pair. Our system was able to outperform its RBMT baseline and turned out to be the best-scored participating system in the manual evaluation. To achieve this, we extended an existing, rule-based MT system with a module for stochastic selection of analysis parse trees that allowed to better cope with parsing errors during the system’s analysis phase. Due to the integration into the analysis phase of the RBMT engine, we are able to preserve the benefits of a rule-based translation system such as proper generation of target language text. Additionally, we used a statistical tool for terminology extraction to improve the lexicon of the RBMT system. We report results from both automated metrics and human evaluation efforts, including examples which show how the proposed approach can improve machine translation quality. 1
The Production of Textured Yarns by Methods other than the False-twist Technique (1987)

(1977). The Production of Textured Yarns by Methods other than the False-Twist Technique. Textile Progress: Vol. 9, No. 3, pp. 1-49.
<i>Streptococcus pyogenes</i>Glycoprotein-Binding Strepadhesin Activity Is Mediated by a Surface-Associated Carbohydrate-Degrading Enzyme, Pullulanase (2003)

The interactions between pathogenic bacteria and the host need to be resolved at the molecular level in order to develop novel antiadhesive drugs and vaccines. We have previously identified strepadhesin, a novel glycoprotein-binding activity in Streptococcus pyogenes binding to thyroglobulin, submaxillar mucin, fetuin, and asialofetuin. The activity is known to be regulated by Mga, a regulator of streptococcal virulence factors, and is carried by the surface-associated streptococcal cysteine protease, SpeB. In the present study, we focused on the high strepadhesin activity in an S. pyogenes strain (NZ131rgg) lacking SpeB expression. By extracting surface proteins from the bacteria, a new strepadhesin protein was identified, and mass spectrometric analysis and database search identified it as a putative pullulanase. The gene was cloned, and the recombinant pullulanase (PulA) exhibited pullulanase and starch hydrolyzing activity, as well as strepadhesin activity. Sequencing of the pulA gene revealed an open reading frame with 3,498 bp encoding a protein of 1,165 amino acids with a predicted molecular mass of 129 kDa. PulA exhibited properties typical for a gram-positive surface protein with a putative signal sequence and LPKTGE cell wall anchoring motif and contained the four highly conserved regions common to pullulanases. Mutant bacteria deficient in PulA expression showed diminished strepadhesin activity on bacterial dot blot assay and reduced adherence to thyroglobulin immobilized on microtiter plates. Thus, S. pyogenes strepadhesin activity is carried by a surface-bound pullulanase, which combines glycoprotein-binding and carbohydrate-degrading activities in the same molecule.
Expression of disease symptoms in cauliflower mosaic virus genomic hybrids. (1984)

In an effort to determine if particular regions of the cauliflower mosaic virus (CaMV) genome could be associated with particular phenotypic characters, strains of CaMV differing markedly in biological properties were recombined to produce hybrids. DNA from pairs of (infectious) genomic clones was cleaved with restriction endonucleases, then mixed and ligated. Recombinants were found by screening transformants in E. coli, or by selection in vivo for infectious hybrids. Recombinants in infected turnip plants were characterized by restriction endonuclease mapping of their DNA to confirm the hybrid genotype. New hybrid strains that induced less severe disease, or conversely, more severe disease than either parent were observed. The experiments revealed that typical disease expression, consisting of leaf chlorosis and mottling, mapped to a genome segment containing open reading frame VI (ORF VI) and the full-length promoter. This basic disease symptom was found to be influenced by other regions of the genome. Insect transmissibility mapped to ORF II. The ability to develop generalized infections in solanaceous plants was tested in hybrids between CaMV CM1841 and a variant that infects Datura stramonium systemically. In this case the systemic mobilization of virus appeared to be controlled by ORF VI, suggesting that this gene may function in cell-to-cell movement of virus.
A recommended method for the preparation of monospecific Brucella sera. (1958)

A method is described in detail for the preparation of monospecific sera for typing brucella cultures. The importance of using entirely smooth cultures throughout the procedure is emphasized. A single intravenous injection of living brucellae in rabbits caused an active infection and the early appearance of high-titre antibodies. Sera obtained five to seven days after inoculation contained a higher proportion of specific antibodies than serum obtained ten days after inoculation. Trial absorptions of each serum sample were performed to determine the relative content of homologous and heterologous antibodies, so that the optimum proportions of absorbing cells to serum could be employed for the final absorption. In this manner sera were obtained which at a 1/160 dilution agglutinated the homologous antigen and at a 1/10 dilution did not agglutinate the heterologous antigen.Monospecific sera were used in typing 180 brucella strains isolated in Great Britain and other countries, and over 3000 cultures recovered from experimental infections. With the exception of two strains of Br. melitensis, all cultures were agglutinated to titre with only one of the monospecific sera.
Iridium Coating: Processes, Properties and Application. Part I (2017)

The successful use in rocket engines of iridium as a barrier coating is an important area of high-temperature application. The Ir coating must be continuous and dense in order to protect the underlying material from corrosion and oxidation. The microstructure and morphology of the coating can be effectively controlled by varying the deposition conditions. The microstructure has an important influence on the physical and mechanical properties of the coating. A number of deposition processes, which have different conditions and requirements, have been employed to produce Ir coatings on various substrate materials. Part I of this paper presents the introduction and reviews the different deposition processes, while Part II will deal with texture and structure evolution, mechanical properties, growth mechanisms and applications of Ir coatings. The mechanisms of micropore formation after high-temperature treatment will also be investigated in some detail.
Type IV Collagen Is Transcriptionally Regulated by Smad1 under Advanced Glycation End Product (AGE) Stimulation (2004)

Prolonged exposure to hyperglycemia is now recognized as the most significant causal factor of diabetic complications. Excessive advanced glycation end products (AGEs) as a result of hyperglycemia in tissues or in the circulation may critically affect the progression of diabetic nephropathy. In diabetic nephropathy, glomerulosclerosis is a typical pathologic feature characterized by the increase of the extracellular matrix (ECM). We have reported previously that alpha1 type IV collagen (Col4) is one of the major components of ECM, which is up-regulated by AGEs, and that the overexpression of Col4 is transcriptionally regulated by an unknown transcription factor binding to the promoter. Here we identified this protein as Smad1 by yeast one-hybrid screening. Using chromatin immunoprecipitation and reporter assay, we observed that Smad1 directly regulated transcription for Col4 through the binding of Smad1 to the promoter of Col4. Smad1 was significantly induced along with Col4 in AGE-treated mesangial cells. Moreover, suppression of Smad1 by antisense morpholino resulted in a decrease of AGE-induced Col4 overproduction. To elucidate the interaction between transforming growth factor-beta and Smad1, we investigated whether activin receptor-liked kinase1 (ALK1) was involved in this regulation. AGE stimulation significantly increased the expression of the ALK1 mRNA in mesangial cells. We also demonstrated that Smad1 and ALK1 were highly expressed in human diabetic nephropathy. These results suggest that the modulation of Smad1 expression is responsible for the initiation and progression of diabetic nephropathy and that blocking Smad1 signaling may be beneficial in preventing diabetic nephropathy and other various diabetic complications.
Leakless, Bipolar Reference Electrodes: Fabrication, Performance, and Miniaturization (2021)

Reference electrodes must maintain a well-defined potential for long periods of time to be useful. The silver/silver chloride (Ag/AgCl) reference electrode is arguably the most widely used reference electrode, but it leaks silver and chloride ions into the sample solution through the porous frit over time. Further, the porous frit makes miniaturization to the micro- and nanoscale challenging. Here, we present an alternative, where the traditional Ag/AgCl reference electrode porous frit is replaced by a conductive wire, preventing ion leakage and allowing miniaturization to the microscale. Charge balance is maintained through a closed bipolar electrochemical mechanism, where faradaic processes occur on each end of the sealed wire. Using the above design, we demonstrate the efficacy of the leakless, bipolar reference electrode (BPRE) and miniaturize it to the microscale (μ-leakless BPRE). Importantly, we demonstrate that leakless and μ-leakless BPREs behave the same as commercial reference electrodes during potentiometric measurements and leakless BPREs perform similarly during voltammetric measurements on ultramicroelectrodes. We demonstrate that the drift during voltammetry using a leakless BPRE on a macroelectrode is slightly more appreciable compared to the drift seen with a commercial reference electrode. We detail design principles for the use of leakless BPREs in nonaqueous solvents and in sealing other conductive materials (<i>e.g.</i>, gold and carbon). Using mass spectrometry, we show that the maximum leakage of methylene blue is 0.36 fmol/s, at least 2 orders of magnitude smaller than that of commercial reference electrodes. Finally, we demonstrate the efficacy of using leakless BPREs in potentiometric glucose sensing.
Nonequilibrium phenomena in ion-implanted MOS capacitors (1974)

A new type of nonequilibrium capacitance-voltage characteristic was observed in a particular class of ion-implanted MOS capacitors. A model explaining these characteristics is proposed and a method to use them for evaluation of the implanted layers is suggested.
Scanning Electrochemical Microscopy. 57. SECM Tip Voltammetry at Different Substrate Potentials under Quasi-Steady-State and Steady-State Conditions (2007)

We discuss SECM tip voltammetry, where a UME tip is held above a conductive substrate within about a tip radius and a tip voltammogram is recorded as its potential is slowly scanned while the substrate is held at a fixed potential. When the potential of the substrate is changed, the series of steady-state tip voltammograms provide information about the reactants and products. When the potential of the substrate, ES, is set so that the reaction at the substrate is opposite to that at the tip (the usual SECM conditions), a total positive feedback (tpf) tip voltammogram is recorded. When the substrate potential is set to values where the reaction at the substrate is the same as that occurring on the tip, the tip is shielded from the species in the bulk solution. Depending upon the substrate potential, this can cause total shielding (ts) or a voltammogram that is the result of partial feedback/partial shielding (pf-ps). The result is a series of tip voltammograms that are characterized by tpf, pf-ps, or ts, depending upon ES. Experimental tip voltammograms resulting from the reversible reduction of TCNQ and oxidation of ferrocene in MeCN are reported. These are compared with those from simulations and approximate equations developed to describe the features of the tip voltammograms generated under tpf, ts, or pf-ps conditions. The effect of the diffusion coefficient ratio on the ability of the UME tip to reach a true steady state is also addressed and possible applications, e.g., obtaining information about the reversibility of an electrochemical reaction, the product of an electrochemical reaction, the stability of that product, or the diffusion coefficients of the electroactive species, are discussed.
Reactions of Intracellular Crystals of Foot-and-Mouth Disease Virus with Ferritin-tagged Antibody (1969)

Summary Crystals of intracellular foot-and-mouth disease virus, type A1, were reacted with ferritin conjugated to an A1 antibody, an O2 antibody, and normal γ-globulin as well as unconjugated ferritin. Specific tagging was demonstrated with both the full and ‘empty’ capsid crystals with type A1 virus and anti-A1 globulin. Anti-O2 ferritin-conjugated globulin, normal ferritin-conjugated γ-globulin and unconjugated ferritin did not attach to the A1 virus and showed only minimal reaction with tissue fragments and debris. Immunodiffusion in agar gel was used to demonstrate the specificity of the reagents.
The role of surfactants in the formulation of elastic liposomal gels containing a synthetic opioid analgesic (2016)

Transdermal drug delivery systems have made significant contributions to the medical community, but have yet to completely substitute oral or parenteral delivery. Recently, various strategies have been used to augment the transdermal delivery of therapeutics. Primarily, they include iontophoresis, electrophoresis, sonophoresis, chemical permeation enhancers, microneedles, and vesicular systems. Among these strategies, elastic liposomes appear promising. Elastic vesicle scaffolds have been developed and evaluated as novel topical and transdermal delivery systems, with an infrastructure consisting of hydrophobic and hydrophilic moieties together, and as a result, such scaffolds can accommodate drug molecules with a wide range of solubility. High deformability of these vesicles provides for better penetration of intact vesicles. This system is much more efficient at delivering low- and high-molecular-weight drugs to the skin in terms of quantity and depth. In this work, elastic liposomes of Tramadol HCl were prepared using a solvent evaporation method with different surfactants and were characterized using microscopy, and particle size, shape, drug content, ex vivo release, and zeta potential were also calculated. The prepared elastic liposomes were found to be in the range of 152.4 nm with a zeta potential of -22.4 mV; the entrapment efficiencies of the selected formulation was found to be 79.71%±0.27%. All formulations in the form of a gel were evaluated for physicochemical properties and were found to be homogeneous with no grittiness, and the pH of all formulations was found to be neutral. The optimized selected elastic liposomal formulation followed the Higuchi equation and Fickian diffusion and released the drug for a period of 24 hours. The overall results provide much promise for the continued investigation of deformable vesicles as transdermal drug carriers.
Acetylcholinesterase Inhibition Improves Tachycardia in Postural Tachycardia Syndrome (2005)

Acute acetylcholinesterase inhibition significantly attenuated tachycardia in POTS. There was also an improvement in symptom burden with this promising therapy.
Effect of Catalyst Constituents on (Ni, Mo, and Cu)/Kieselguhr-Catalyzed Sucrose Hydrogenolysis (2005)

The multicomponent (Ni, Mo, and Cu) catalyst supported on kieselguhr was found to have a high activity for the hydrogenolysis of sucrose to produce industrially important glycerol, ethylene glycol, propylene glycol, and sorbitol. The catalyst was characterized by scanning electron microscopy, X-ray diffraction, and surface area measurement. The presence of Ni is very common in most of the catalysts used for this process. The presence of Mo and Cu promotes the activity of Ni when supported on kieselguhr. The concentrations of Ni, Mo, and Cu in the catalyst have been optimized to yield maximum glycerol during sucrose hydrogenolysis.
WHEN CHILDREN DIE (1985)

Mae Shirley Cook is coordinator of hospital ministries for Handi*Vangelism, a ministry of BCM International. She is a contributing author to The Spiritual Needs of Children.
Thermogelling Platform for Baicalin Delivery for Versatile Biomedical Applications (2018)

Baicalin (BG) is a natural glycoside with several promising therapeutic and preventive applications. However, its pharmaceutical potential is compromised by its poor water solubility, complex oral absorption kinetics, and low bioavailability. In this work, BG was incorporated in a series of chitosan (Ch)/glycerophosphate (GP)-based thermosensitive hydrogel formulations to improve its water solubility and control its release profile. Molecular interactions between BG and GP were investigated using Fourier transform infrared spectroscopy (FT-IR), and the ability of GP to enhance the water solubility of BG was studied in different release media. Drug-loaded Ch/GP hydrogels were prepared and characterized for their gelation time, swelling ratio, and rheological properties in addition to surface and internal microstructure. Polyethylene glycol (PEG) 6000 and hydroxypropyl methyl cellulose (HPMC) were incorporated in the formulations at different ratios to study their effect on modulating the sol-gel behavior and the in vitro drug release. In vivo pharmacokinetic (PK) studies were carried out using a rabbit model to study the ability of drug-loaded Ch/GP thermosensitive hydrogels to control the absorption rate and improve the bioavailability of BG. Results showed that the solubility of BG was enhanced in the presence of GP, while the incorporation of PEG and/or HPMC had an impact on gelation time, rheological behavior, and rate of drug release in vitro. PK results obtained following buccal application of drug-loaded Ch/GP thermosensitive hydrogels to rabbits showed that the rate of BG absorption was controlled and the in vivo bioavailability was increased by 330% relative to BG aqueous oral suspension. The proposed Ch/GP thermosensitive hydrogel is an easily modifiable delivery platform that is not only capable of improving the solubility and bioavailability of BG following buccal administration but also can be suited for various local and injectable therapeutic applications.