gebhart/patrepeval huggingface dataset:
Isomerization of Normal Butenes (1934)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIsomerization of Normal ButenesV. N. Ipatieff, Herman Pines, and R. E. SchaadCite this: J. Am. Chem. Soc. 1934, 56, 12, 2696–2698Publication Date (Print):December 1, 1934Publication History Published online1 May 2002Published inissue 1 December 1934https://pubs.acs.org/doi/10.1021/ja01327a050https://doi.org/10.1021/ja01327a050research-articleACS PublicationsRequest reuse permissionsArticle Views158Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Isolation and characterization of new facultatively alkalophilic strains of Bacillus species (1986)

Four facultatively alkalophilic isolates were purified from enrichment cultures initiated with lime-treated garden soil. Four isolates, OF1, OF3, OF4, and OF6, were obligately aerobic, spore-forming, gram-positive, motile rods which were capable of growth at both pH 7.5 and pH 10.5. Strains OF1 and OF6 grew best at the lower pH value; and whereas growth of these strains at pH 10.5 was completely dependent on added Na+, growth at pH 7.5 was only partially dependent on added Na+. Strains OF3 and OF4 grew better at pH 10.5 than at pH 7.5, with strain OF3 growing modestly over its entire pH range, while OF4 grew well. Growth of OF3 and OF4 was completely dependent on added Na+ at both pH 7.5 and pH 10.5. DNA-DNA hybridization studies indicated that OF1 and OF6 are closely related strains but are not related to the other isolates, Bacillus subtilis, or two previously studied obligately alkalophilic bacilli. OF3 was unrelated to any of the other organisms examined in the study, whereas OF4 showed complete homology with obligately alkalophilic Bacillus firmus RAB. All four isolates maintained a cytoplasmic pH that was considerably lower than the external pH when the latter was 10.5. Although substantial transmembrane electrical potentials were observed, the total electrochemical proton gradient (delta mu H+) was low at pH 10.5 in all the strains. By contrast, delta mu H+ was substantial at pH 7.5 and at that pH was composed entirely of an electrical potential. These results are in contrast to previous findings that obligately alkalophilic bacilli generate only small electrical potentials at near neutral pH. All the isolates exhibited substantial rates of respiration as measured by oxygen consumption. Neither respiration nor NADH oxidation by everted membrane vesicles was significantly stimulated by Na+. Analyses of reduced versus oxidized difference spectra of membranes from OF4 showed that the total membrane cytochrome content was considerably higher in cells grown at pH 10.5 than at pH 7.5, with the levels of c- and a-type cytochromes exhibiting the largest pH-dependent differences. Initial examination of membrane protein profiles on gel electrophoresis also indicated a number of changes in pattern in each isolate, depending on the growth pH.
Fuzzy rule extraction from a multilayered neural network (2002)

A fuzzy rule extraction method from a multilayered neural network is proposed to realize the multiplicative merits of neural and fuzzy theories. The proposed method uses a fuzzy-neuron network structure which includes input and output layers that convert input signals to membership values. An evaluation index, called the 'casual index' can evaluate the weights which are acquired by learning and can translate the internal knowledge of the network into fuzzy rules. Simulations using test data whose relationships are known a priori demonstrated the ability of the proposed method to extract fuzzy rules properly from a multilayered neural network.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Acute leukemias of different lineages have similar MLL gene fusions encoding related chimeric proteins resulting from chromosomal translocation. (1993)

The MLL gene, on human chromosome 11q23, undergoes chromosomal translocation in acute leukemias, resulting in gene fusion with AF4 (chromosome 4) and ENL (chromosome 19). We report here translocation of MLL with nine different chromosomes and two paracentric chromosome 11 deletions in early B cell, B- or T-cell lineage, or nonlymphocytic acute leukemias. The mRNA translocation junction from 22 t(4;11) patients, including six adult leukemias, and nine t(11;19) tumors reveals a remarkable conservation of breakpoints within MLL, AF4, or ENL genes, irrespective of tumor phenotype. Typically, the breakpoints are upstream of the zinc-finger region of MLL, and deletion of this region can accompany translocation, supporting the der(11) chromosome as the important component in leukemogenesis. Partial sequence of a fusion between MLL and the AFX1 gene from chromosome X shows the latter to be rich in Ser/Pro codons, like the ENL mRNA. These data suggest that the heterogeneous 11q23 abnormalities might cause attachment of Ser/Pro-rich segments to the NH2 terminus of MLL, lacking the zinc-finger region, and that translocations occur in early hematopoietic cells, before commitment to distinct lineages.
High Intensity Magnetic Filtration (1972)

A high intensity magnetic filter (HIMF) developed at the FBNML during a search for magnetic monopoles, permits the selective separation of even weakly paramagnetic micron‐size particles at high flow rates. By contrast conventional magnetic separators are effective only for considerably larger, ferromagnetic particles and are used to separate iron ores and tramp iron.
Multi-attention Network for Thoracic Disease Classification and Localization (2019)

The chest X-ray is one of the most commonly available radiological examinations for diagnosing lung diseases. This task remains a major challenge due to 1) the shortage of accurate annotations for chest X-ray examinations, 2) the diversity of lesion areas on X-rays from different thoracic disease and 3) the problem of class imbalance in existing chest X-ray databases. In this paper, we propose a new multi-attention convolutional neural network for thoracic disease classification and localization. First, the framework is equipped with squeeze-and-excitation (SE) block as a feature attention module to offer a chance of cross-channel feature recalibration. Second, we propose a novel space attention module to combine global and local information. Third, we present a hard examples attention module to alleviate the class imbalance problem. The comprehensive experiments are performed on the ChestX-ray14 dataset. Quantitative and qualitative results demonstrate that our method outperforms the state-of-the-art algorithm.
Lipid transfer proteins: classification, nomenclature, structure, and function (2016)

The non-specific lipid transfer proteins (LTPs) constitute a large protein family found in all land plants. They are small proteins characterized by a tunnel-like hydrophobic cavity, which makes them suitable for binding and transporting various lipids. The LTPs are abundantly expressed in most tissues. In general, they are synthesized with an N-terminal signal peptide that localizes the protein to spaces exterior to the plasma membrane. The in vivo functions of LTPs are still disputed, although evidence has accumulated for a role in the synthesis of lipid barrier polymers, such as cuticular waxes, suberin, and sporopollenin. There are also reports suggesting that LTPs are involved in signaling during pathogen attacks. LTPs are considered as key proteins for the plant's survival and colonization of land. In this review, we aim to present an overview of the current status of LTP research and also to discuss potential future applications of these proteins. We update the knowledge on 3D structures and lipid binding and review the most recent data from functional investigations, such as from knockout or overexpressing experiments. We also propose and argument for a novel system for the classification and naming of the LTPs.
A discrete-time feedback controller for containerized cloud applications (2016)

Modern Web applications exploit Cloud infrastructures to scale their resources and cope with sudden changes in the workload. While the state of practice is to focus on dynamically adding and removing virtual machines, we advocate that there are strong benefits in containerizing the applications and in scaling the containers.
High efficiency diode comb-laser for DWDM optical interconnects (2014)

High efficiency operation of two types of quantum dot comb-laser is demonstrated at elevated temperature. Their energy efficiencies correspond to 0.6 pJ/bit at 12.5 Gbps and 1 pJ/bit at 25 Gbps at 80°C.
Resynthesis of multi-level circuits under tight constraints using symbolic optimization (2003)

We apply recently introduced constructive multi-level synthesis in the resynthesis loop, targeting convergence of industrial designs. The incremental ability of the resynthesis approach allows more predictable circuit implementations while allowing their aggressive optimization. The approach is based on a very general symbolic decomposition template for logic synthesis that uses information-theoretical properties of a function to infer its decomposition patterns (rather than more conventional measures such as literal counts). Using this template the decomposition is done in a Boolean domain unrestricted by the representation of a function, enabling superior implementation choices driven by additional technological constraints. The symbolic optimization is applied in resynthesis of industrial circuits which have tight timing constraints yielding their much improved timing properties.
Endogenous Pro- and Anti-Inflammatory Cytokines Differentially Regulate an In Vivo Humoral Response to<i>Streptococcus pneumoniae</i> (2002)

Proinflammatory cytokines play a critical role in innate host defense against extracellular bacteria. However, little is known regarding the effects of these cytokines on the adaptive humoral response. Mice injected with a neutralizing anti-tumor necrosis factor alpha (TNF-alpha) monoclonal antibody (MAb) at the time of primary immunization with intact Streptococcus pneumoniae (strain R36A) showed a substantial reduction in both the primary immunoglobulin G (IgG) response specific for the cell wall protein, pneumococcal surface protein A (PspA), as well as in the development of PspA-specific memory. In contrast, anti-TNF-alpha MAb injected only at the time of secondary immunization with R36A failed to alter the boosted anti-PspA response. TNF-alpha was required only within the first 48 to 72 h after primary immunization with R36A and was induced both by non-B and non-T cells and by lymphoid cells, within 2 to 6 h after immunization, with levels returning to normal by 24 h. Thus, the early innate release of TNF-alpha was critical for optimal stimulation of the subsequent adaptive humoral response to R36A. Additional proinflammatory (interleukin 1 [IL-1], IL-6, IL-12, and gamma interferon [IFN-gamma]) as well as anti-inflammatory (IL-4 and IL-10) cytokines were also transiently induced. Mice genetically deficient in IL-6, IFN-gamma, or IL-12 also showed a reduced IgG anti-PspA response of all IgG isotypes. In contrast, IL-4(-/-) and IL-10(-/-) mice immunized with R36A showed a significant elevation in the IgG anti-PspA response, except that there was decreased IgG1 in IL-4(-/-) mice. In this regard, a marked enhancement in the induction of proinflammatory cytokines was observed in the absence of IL-10, relative to controls. Ig isotype titers specific for the phosphorycholine determinant of C-polysaccharide were similarly regulated, but to a much more modest degree. These data suggest that proinflammatory and anti-inflammatory cytokines differentially regulate an in vivo protein- and polysaccharide-specific Ig response to an extracellular bacteria.
Image‐guided video assisted thoracoscopic surgery (iVATS) ‐ phase I‐II clinical trial (2015)

A successful and safe step-wise process has been established for iVATS, combining intra-operative C-arm CT scanning and thoracoscopic surgery in a hybrid operating room.
Animal models for acute radiation syndrome drug discovery (2015)

There are a number of well-defined animal models, the mouse, canine and NHP, that are being used for the development of MCMs. Additional animal models, such as the minipig, are under development to further assist in the identification, efficacy testing and approval of MCMs under the FDA Animal Efficacy Rule.
<i>In vitro</i> evaluation of phosphonylated low‐density polyethylene for vascular applications (2002)

The use of catheters for vascular applications is often complicated by the development of friction between the catheter material and the vessel wall, which leads to endothelial cell removal and intimal lesions. Phosphonylation, a chemical surface treatment, has been proposed as a means of increasing the hydrophilicity of low-density polyethylene (LDPE), a commonly used catheter material, in efforts to impart lubricity to the material and reduce vascular tissue damage. In an in vitro tribological study, phosphonylated LDPE produced a lower coefficient of friction and allowed greater retention of endothelial cells on vessels as compared to untreated LDPE when the materials were reciprocated against normal porcine aorta. Chemical characterizations of the LDPE before and after friction testing involving Fourier transform infrared and energy-dispersive X-ray (EDX) confirmed the phosphorus content on phosphonylated LDPE. Election spectroscopy for chemical analysis (ESCA) and atomic force micrscope (AFM) analyses verified that proteins initially adsorb to both the phosphonylated and untreated LDPE surfaces and that the proteins interfere with water to lubricate the surfaces. However, with repeated friction, proteins are removed from the surface and hydrophilicity, as imparted by phosphonylation, becomes a principal factor in the lubrication process.
Poly(<scp>d</scp>-glucose carbonate) Block Copolymers: A Platform for Natural Product-Based Nanomaterials with Solvothermatic Characteristics (2013)

A natural product-based polymer platform, having the characteristics of being derived from renewable materials and capable of breaking down, ultimately, into natural byproducts, has been prepared through the ring-opening polymerization (ROP) of a glucose-based bicyclic carbonate monomer. ROP was carried out via chain extension of a polyphosphoester (PPE) macroinitiator in the presence of 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) organocatalyst to afford the PPE-b-poly(D-glucose carbonate) (PDGC) block copolymer. This new copolymer represents a functional architecture that can be rapidly transformed through thiol-yne reactions along the PPE segment into a diverse variety of amphiphilic polymers, which interestingly display stimuli-sensitive phase behavior in the form of a lower critical solution temperature (LCST). Below the LCST, they undergo self-assembly to form spherical core-shell nanostructures that display a poorly defined core-shell morphology. It is expected that hydrophobic patches are exposed within the micellar corona, reminiscent of the surface complexity of proteins, making these materials of interest for triggered and reversible assembly disassembly processes.
Content-based peer-to-peer network overlay for full-text federated search (2007)

Peer-to-peer network overlays have mostly been designed to support search over document names, identifiers, or keywords from a small or controlled vocabulary. In this paper we propose a content-based P2P network overlay for full-text federated search over heterogeneous, open-domain contents. Local algorithms are developed to dynamically construct a network overlay with content-based locality and content-based small-world properties. Experimental results using P2P testbeds of real documents demonstrate the effectiveness of our approach.
Aspects of follicular and oocyte maturation that affect the developmental potential of embryos. (1999)

The ability to mature, be fertilized and finally to develop into a viable embryo is acquired gradually by the oocyte during progressive differentiation throughout folliculogenesis. This process starts with oocyte growth during the first steps of follicular development. As the oocyte is close to its final size, other modifications occur, less spectacular but at least as important in determining the resulting ability of the oocyte to accomplish its reproductive purpose (developmental competence). These modifications, referred to as 'oocyte capacitation', are probably influenced by the follicle. The proportion of developmentally competent oocytes increases with follicular size. However, the relationship between follicular growth and oocyte competence is not very strict, since a given oocyte may acquire its competence at any stage of follicular growth and since some examples of functional disjunction between follicular size and oocyte competence are described. Follicular atresia may impair the acquisition of oocyte competence, as evidenced by the parallel study of follicular characteristics and of the developmental potential of their oocytes treated individually through in vitro maturation, fertilization and development. However, when atresia is experimentally induced in large preovulatory follicles, oocytes remain competent, indicating that once competence is acquired, it is no longer sensitive to atresia. Oocyte maturation represents only the end of this long and progressive process and validates the preparation of the oocyte by conferring its final developmental ability. As evidenced by recent cloning experiments, the cytoplasmic aspects of oocyte maturation are crucial for the acquisition of developmental competence. This cytoplasmic maturation may be activated in vitro by the use of complex media supplement (serum, follicular fluid) but the use of defined media for maturation allowed the identification of some active factors (such as epidermal growth factor, growth hormone, inhibin and activin). The study of some differential models of oocyte competence (follicular size and atresia, Booroola gene, prepubertal oocytes) will provide a better understanding of oocyte capacitation and maturation, and allow the improvement of in vitro methods for oocyte maturation, which represent the most limiting step of in vitro production of embryos in large mammals.
Operating system penetration (1975)

One of the favorite diversions of university students involves beating the system. In the case of operating systems, this has been a remarkably easy accomplishment. An extensive lore of operating penetration, ranging from anecdotes describing students who have outsmarted the teacher's grading program to students who captured the system's password list and posted it on one of the bulletin boards, has been collected on college campuses. Private industry has been victimized much more seriously. Here the lore of system penetrations contains scenarios involving the loss of tens of thousands of dollars.
Dual-Signaling Fluorescent Chemosensors Based on Conformational Restriction and Induced Charge Transfer (2001)

Twist and shout! By restricting conformation, 2,6-biarylpyridines can be induced to "speak" to us through increased fluorescence emission. In combination with induced charge transfer, this allows these simple fluorophores to reveal otherwise silent binding events to alkali metal and alkaline earth cations through brightening and color change (see picture; from left to right: no metal, Li<sup>+</sup> , Mg<sup>2+</sup> , and Ca<sup>2+</sup> ).
High-spatial-resolution nulling microellipsometer using rotational polarization symmetry (2010)

We report the design and experimental testing of a high-spatial-resolution nulling microellipsometer. This microellipsometer design is based on the previously reported principle of rotational polarization symmetry to improve the signal-to-noise ratio of spatially resolved ellipsometric measurements. Through the use of an electro-optic polarization rotator, a null detection scheme is made possible and implemented. Surface profiling of a lithographically patterned microstructure is demonstrated with the nulling microellipsometer. A lateral spatial resolution of 0.48 microm is calculated with a numerical aperture of 0.9 and an illumination wavelength of 632.8 nm.
Computation of Synthetic Seismograms with the Reflectivity Method and Comparison with Observations (1971)

The reflectivity method for the computation of synthetic seismograms, as devised by Fuchs, is extended to include the elastic transmission losses and time shifts due to a stack of layers on top of the reflecting medium. Numerical details of this method are described, and a comparison with the ray-theoretical method, as devised by Müller, is given. The results of both methods agree well if the models are not too complicated. The field of application of these methods is the comparison with observed seismograms obtained from refraction studies of the Earth's crust and upper mantle. The reflectivity method is applied to the interpretation of observations along a profile in Central Europe. The compressional velocity of the lower crust beneath this profile increases gradually without showing a pronounced structure. At the Mohorovčić discontinuity whose depth is about 27 km the velocity increases from 6.8 to 8.0 km s−1. The zone immediately below the Moho is homogeneous, followed by an increase in velocity to 8.15 km s−1 at a depth of about 35 km.
The<i>Fusarium solani</i>Gene Encoding Kievitone Hydratase, a Secreted Enzyme that Catalyzes Detoxification of a Bean Phytoalexin (1995)

Among the antimicrobial phytoalexins produced by Phaseolus vulgaris (French bean) is the prenylated isoflavonoid, kievitone. The bean pathogen, Fusarium solani f. sp. phaseoli, secretes a glycoenzyme, kievitone hydratase (EC 4.2.1.95), which catalyzes conversion of kievitone to a less toxic metabolite. Among F. solani strains, those that are highly virulent to P. vulgaris also produce kievitone hydratase constitutively, suggesting that the enzyme is a virulence factor. Based on the N-terminal amino acid sequence of purified enzyme, the kievitone hydratase cDNA and gene (khs) were cloned. The identities of khs and the cDNA were confirmed by their expression in transgenic Neurospora crassa and Emericella nidulans. Based on the gene and cDNA sequences, khs is predicted to encode a preprotein of 350 amino acids, from which a 19 amino acid N-terminal transit peptide is removed during maturation and secretion. The predicted mass of the mature polypeptide, 37 kDa, contrasts with the 47 to 49 kDa size estimated by electrophoresis of purified enzyme, confirming that the enzyme is extensively glycosylated. The inferred polypeptide sequence has seven canonical sites for N-glycosylation. Southern blot-hybridization analysis of F. s. f. sp. phaseoli DNA indicates one khs locus and an additional locus with weak hybridization to the khs probe. Sequences related to khs were also detected in several isolates of F. solani and the related teleomorph, Nectria haematococca. However, strains of F. oxysporum known to exhibit inducible kievitone hydratase activity (but not pathogenic to bean) did not have detectable khs homology. Nevertheless, all isolates known to cause severe disease on bean possessed khs sequence.