gebhart/patrepeval huggingface dataset:
FEM analysis of inverter-induction motor rotor conduction losses (1989)

A direct method to simulate the steady-state stator and rotor currents in an inverter-induction machine of known geometry and winding design is developed, and the FEM (finite element method) analysis of the skin effect problem is used to determine the variation of rotor resistance with rotor current frequency. The rotor conduction loss can be calculated from these two sets of information. The total losses incurred for a particular mode of inverter operation are determined both experimentally and using the analytical procedure developed here. The total calculated loss is only 3.5% greater than the measured amount, which confirms the validity of the theory developed and its computer implementation. Furthermore, experimental and simulation results of the standstill condition with sinusoidal input were also found to be in close agreement. Finally, the proposed procedure yields information on the instantaneous current distribution throughout the machine, which permits the accurate determination of the flux pattern and optimization of the lamination design.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Defect generation in trench isolation (1984)

Defect generation in silicon during trench isolation process has been studied. Several sources of defect generation have been identified using Secco etching. These include contamination from the redeposited oxide layer during the trench etch and the stress induced at trench corners during the trench cap and field oxidation. A Sealed Sidewall Trench (SST) isolation process has been developed which results in defect-free trench isolation structures. A key addition to the refill dielectrics in SST is the incorporation of nitride layer(s) for inhibiting excessive vertical bird's beaking.
Effects of anti‐epileptic drugs on glutamine synthetase activity in mouse brain (1999)

1. Glutamine synthetase (GS) is a key enzyme in the regulation of glutamate neurotransmission in the central nervous system. It is responsible for the conversion of glutamate to glutamine, and for the detoxification of ammonia. 2. We have investigated the effects of single and repeated intraperitoneal administration of a range of established and new anti-epileptic drugs on GS activity in mouse brain. 3. Four hours after the final dose, animals were sacrificed and the brains removed for analysis of GS activity. 4. Both single and repeated doses of phenytoin and carbamazepine were found to reduce enzyme activity (P<0.05). 5. Single doses of phenobarbitone, felbamate and topiramate were without effect, however repeated administration of these drugs dose-dependently reduced GS activity (P<0.05). 6. Single and repeated doses of sodium valproate, vigabatrin, lamotrigine, gabapentin, tiagabine, levetiracetam and desglycinyl-remacemide were found to have no effect on GS activity. 7. The reduction in enzyme activity demonstrated is unlikely to be related to the anti-epileptic actions of these drugs, but may contribute to their toxicity.
Quantitatively different red cell/nucleated cell chimerism in patients with long-term, persistent hematopoietic mixed chimerism after bone marrow transplantation for thalassemia major or sickle cell disease (2010)

The proportions of donor-derived nucleated cells in four transplanted patients affected by hemoglobinopathies were 71%, 46%, 15% and 25% at day 1364, 1385, 1314 and 932, respectively. Similar results were obtained for the erythroid precursors, analyzing the donor/recipient origin of the burst-forming unit - erythroid colonies. In contrast, on the same days of observation, the proportions of donor-derived erythrocytes in the four patients with persistent mixed chimerism were 100%, 100%, 73% and 90%. Conclusions Our results showed that most of the erythrocytes present in four long-term transplanted patients affected by hemoglobinopathies and characterized by the presence of few donor engrafted nucleated cells were of donor origin. The indication that small proportions of donor engrafted cells might be sufficient for clinical control of the disease in patients affected by hemoglobinopathies is relevant, although the biological mechanisms underlying these observations need further investigation.
Making the future safe for the past (1998)

We present GJ, a design that extends the Java programming language with generic types and methods. These are both explained and implemented by translation into the unextended language. The translation closely mimics the way generics are emulated by programmers: it erases all type parameters, maps type variables to their bounds, and inserts casts where needed. Some subtleties of the translation are caused by the handling of overriding.GJ increases expressiveness and safety: code utilizing generic libraries is no longer buried under a plethora of casts, and the corresponding casts inserted by the translation are guaranteed to not fail.GJ is designed to be fully backwards compatible with the current Java language, which simplifies the transition from non-generic to generic programming. In particular, one can retrofit existing library classes with generic interfaces without changing their code.An implementation of GJ has been written in GJ, and is freely available on the web.
[Obtaining specific antigens of enzootic bovine leukemia virus]. (1986)

The authors presented two methods of producing BLV antigens which had been proved and are utilized now at the Veterinary Institute in Pulawy. One of them is based on cultivation of blood leukocytes from leukotic cattle and on extraction of antigenic material with ethyl ether. The second method consists in obtaining antigenic proteins from a monolayer FLK-BLV culture by means of ammonium sulphate precipitation. The preparations obtained according to the above techniques showed specific serological properties and correspond with foreign standards.
Estimated pay mapping using three-dimensional seismic data and incremental pay thickness modeling (1990)

Abstract Better estimates of hydrocarbon pay thickness and reservoir distribution are achieved if forward modeling is combined with crossplot cluster analysis before the seismic amplitude and isochron data are converted into estimates of pay thickness. To facilitate this process, an enhanced convolutional modeling technique that incorporates petrophysical data and equations into the synthetic seismogram generation process was developed. These incremental pay thickness (IPT) forward models provide the pertinent seismic and petrophysical values required for crossplot analysis. The crossplot analyses then define which seismic variables (trough amplitude, peak amplitude, time structure, isochron, etc.) are most uniquely related to a pay thickness parameter (gross thickness, net thickness, net porosity thickness, or hydrocarbons in place).Work to date, mostly in offshore Gulf Coast gas sands, has shown significant variation in the crossplot transforms required to convert seismic data to estimated pay maps. As such, an interactive, model-based, interpretive approach is recommended as an appropriate means to integrate petrophysical, geologic, and 3-D seismic data in the creation of reservoir pay maps.
The detection of specific IgM to infectious bronchitis virus in chicken serum using an elisa (1986)

An ELISA is reported for the detection of specific IgM to infectious bronchitis virus (IBV) in serum samples from IBV-infected chickens. Both IgM and IgG antibodies to a heterologous, as well as to a homologous, strain could be detected by the ELISA. The IgM response was both rapid and transient, suggesting that its detection could be used as a means of identifying a recent IBV infection. Because IgG appeared to compete successfully with IgM for sites on the viral antigen, it was found necessary to separate IgM from IgG prior to testing in the ELISA.
Identification of DNA-binding proteins that recognize a Conserved Type I repeat sequence in the replication origin region of Tetrahymena rDNA (1994)

An origin of DNA replication has been mapped within the 5' non-transcribed spacer region of the amplified macronuclear rRNA genes (rDNA) of Tetrahymena thermophila. Mutations in 33 nt conserved AT-rich Type I repeat sequences located in the origin region cause defects in the replication and/or maintenance of amplified rDNA in vivo. Fe(II)EDTA cleavage footprinting of restriction fragments containing the Type I repeat showed that most of the conserved nucleotides were protected by proteins in extracts of Tetrahymena cells. Two classes of proteins that bound the Type I repeat were identified and characterized using synthetic oligonucleotides in electrophoretic mobility shift assays. One of these, ds-TIBF, bound preferentially to duplex DNA and exhibited only moderate specificity for Type I repeat sequences. In contrast, a single-stranded DNA-binding protein, ssA-TIBF, specifically recognized the A-rich strand of the Type I repeat sequence. Deletion of the 5' or 3' borders of the conserved sequence significantly reduced binding of ssA-TIBF. The binding properties of ssA-TIBF, coupled with genetic evidence that Type I sequences function as cis-acting rDNA replication control elements in vivo, suggest a possible role for ssA-TIBF in rDNA replication in Tetrahymena.
Performance enhancement of microwave circuits using parallel-strip line (2010)

Nowadays, demands for compactness, light weight, and broadband have a great impact on design issues at both component and system levels in wireless communications. Multilayered structures fabricated with low-temperature co-fired ceramic (LTCC) technologies have been developed recently in response to these demands. With this trend, double-sided printed circuits using conventional fabrication techniques with lower cost have been receiving plenty of attention. The parallel-strip line, belongs to the family of balanced transmission lines. The conventional printed circuit board technology is able to realize it easily. It is a simple structure comprised of a piece of dielectric substrate sandwiched by two conducting traces. Signals flowing on the upper and lower conductors are always equal in magnitude and 180° out of phase; therefore, parallel-strip line has an inherent advantage of easy realization of a balanced configuration. Balanced or double balanced microwave circuits, such as amplifier, mixer, and antenna, are frequently employed in high-performance wireless communications systems, and they can be directly fed by parallel-strip lines. In contrast, microstrip line is an unbalanced transmission line; therefore, extra effort of designing balanced to unbalanced structures (balun) is required for using microstrip transmission lines.
Diagnostic criteria to distinguish hypocellular acute myeloid leukemia from hypocellular myelodysplastic syndromes and aplastic anemia: recommendations for a standardized approach (2009)

Members of the French-American-British Cooperative Leukemia Working Group met to review cases of aplastic anemia, hypocellular myelodysplastic syndrome and hypocellular acute myeloid leukemia. Criteria were proposed and modified following three workshops. Additional input was obtained from another hematopathologist with a special interest in bone marrow histology and immunohistochemistry. Guidelines were recommended based on the workshop results as well as additional studies including selective immunohistochemistry, flow cytometry and cytogenetics.
Efficient Recombinase-Mediated Cassette Exchange in hPSCs to Study the Hepatocyte Lineage Reveals AAVS1 Locus-Mediated Transgene Inhibition (2015)

Tools for rapid and efficient transgenesis in "safe harbor" loci in an isogenic context remain important to exploit the possibilities of human pluripotent stem cells (hPSCs). We created hPSC master cell lines suitable for FLPe recombinase-mediated cassette exchange (RMCE) in the AAVS1 locus that allow generation of transgenic lines within 15 days with 100% efficiency and without random integrations. Using RMCE, we successfully incorporated several transgenes useful for lineage identification, cell toxicity studies, and gene overexpression to study the hepatocyte lineage. However, we observed unexpected and variable transgene expression inhibition in vitro, due to DNA methylation and other unknown mechanisms, both in undifferentiated hESC and differentiating hepatocytes. Therefore, the AAVS1 locus cannot be considered a universally safe harbor locus for reliable transgene expression in vitro, and using it for transgenesis in hPSC will require careful assessment of the function of individual transgenes.
Single-wall carbon nanotubes (2000)

Solid-state devices in which electrons are confined to two-dimensional planes have provided some of the most exciting scientific and technological breakthroughs of the last 50 years. From metal-oxide-silicon field effect transistors to high-mobility gallium-arsenide heterostructures, these devices have played a key role in the microelectronics revolution and are critical components in a wide array of products from computers to compact-disk players. From a more parochial perspective, the study of electrons in two-dimensional systems has also been responsible for two Nobel prizes in physics – to Klaus von Klitzing in 1985 and to Robert Laughlin, Horst Störmer and Daniel Tsui in 1998. This is testimony to the basic as well as applied interest of such devices (see Heiblum and Stern in further reading).
Regulation of expression of a baculovirus ecdysteroid UDPglucosyltransferase gene (1990)

The Autographa californica nuclear polyhedrosis virus egt gene encodes an ecdysteroid UDPglucosyltransferase which catalyzes the transfer of glucose from UDPglucose to ecdysteroid insect molting hormones. Expression of this gene allows the virus to block molting and pupation of infected insect larvae. In this study, we present the nucleotide sequence of the A. californica nuclear polyhedrosis virus egt gene and characterize egt gene expression at the transcriptional and translational levels. egt was transcribed as two 5'-coterminal mRNAs early in infection. Transferase activity was detected in infected cells and in the extracellular fluid by 3 h after infection. The majority of the activity accumulated in the extracellular fluid. We show that the egt gene product is a 60-kilodalton protein which is secreted from the infected cell. The egt gene is located in a region of the A. californica nuclear polyhedrosis virus genome which exhibited hypervariability in serially passaged virus stocks. Nucleotide sequence analysis revealed that the most common deletion occurring in these serially passaged virus isolates is located in the egt gene.
Comparison of two control strategies in development of high-torque electronically commutated drive (1992)

The paper presents an exploration of alternative control strategies for a high-torque brushless drive involving a permanent magnet rotor making use of NdFeB magnets. The efficiency of control over a speed range is explored, together with the response of the system to changes in speed demand and load. Two position control schemes are described and their performance is compared for different load conditions.
Upaya Internalisasi Nilai Kearifan Lokal Masyarakat Waerebo Sebagai Ikon Wisata Manggarai (2021)

Background: Waerebo merupakan kampung destinasi wisata di Kabupaten Manggarai. Kampung tersebut memiliki nilai kearifan lokal yang tinggi, namun mengalami penggerusan akibat berkembangnya ilmu pengetahuan dan teknologi. Dalam mempertahankan eksistensi kearifan lokal tersebut upaya internalisasi untuk menjaga kelestarian budaya masyarakat sebagai aset sejarah tanpa dipengaruhi oleh budaya asing (local jenius). Metode: Metode yang digunakan adalah metode deskriptif dengan teknik observasi, wawancara, dan dokumentasi. Mitra kegiatan adalah masyarakat adat kampung Waerebo, peserta kegiatan difokuskan pada tetua adat seperti tu’a golo, tu’a teno, tu’a panga dan tu’a kilo. Pengabdian dilakukan dengan persiapan, pelaksanaan, pengelolaan dan hasil pengabdian. Pelaksanaan kegiatan dilakukan dengan sosialisasi, pembinaan, dan wawancara tentang internalisasi kearifan lokal masyarakat kampung adat Waerebo. Hasil: Hasil pendampingan terhadap masyarakat Tetua Adat selama kegiatan sosialisasi sangatlah baik. Temuan data PkM adalah (1) Sejarah kampung Waerebo, diantaranya: keturunan asli masyarakat Waerebo, asal mula penamaan desa Waerebo, (2) Keaslian budaya desa adat Waerebo, diantaranya: mbaru niang, kesenian, hubungan dengan Tuhan, leluhur, alam, sesama, dan makna go’et masyarakat Waerebo. Kesimpulan: Kegiatan sosialisasi terkait internalisasi nilai-nilai kearifan lokal mampu memberikan pendalaman makna terkait pentingnya mempertahankan keaslian adat kampung Waerebo.
Mutant p53 proteins have diverse intracellular abilities to oligomerize and activate transcription. (1993)

Accumulating evidence supports the hypothesis that tumor-suppressor p53 can act as a transcriptional activator. Insertion of high-affinity p53 DNA binding sites upstream of a promoter yields a p53-responsive vector. Chimeric proteins fusing p53 and the GAL4 DNA-binding domain demonstrate the presence of a transcriptional activating domain in the N-terminus of p53. GAL4-p53 chimeras constructed using naturally occurring p53 mutations at either codon 141 (Tyr-141) or 175 (His-175) of p53 had little ability to activate the reporter gene; in contrast, mutations at either codon 248 (Trp-248) or 273 (His-273) produced greater transcriptional activities than did wild-type p53. GAL4 chimeras can be used to analyse interactions between different domains of p53 and between different p53 alleles; a DNA binding site is defined, and a simple measurement can be made of function. We had expected that coexpression of GAL4 chimeras and p53 alleles would squelch transcriptional activation downstream of GAL binding sites. Surprisingly, coexpression of either p53 (Trp-248) or (His-273) with the GALA-p53 (wild-type, His-273, Trp-248, His-175, Tyr-141) effectors conferred an increase in transcriptional activation as compared with the effector alone. Oligomerization of p53 alleles with GAL4-p53 chimeras could underlie this effect, leading to an increase in transcription-activating motifs near the promoter. To test this possibility, we constructed a GAL4-p53 C-terminal chimera with p53 residues 160-393, lacking the transcriptional activating domain but retaining regions believed to be important in p53 oligomerization. Neither GAL4-p53 (C-terminus) nor p53 expression vectors were able to transactivate G5E1B-CAT alone. Both p53 (His-273) and (Trp-248) co-expressed with GAL4-p53 (C-terminus) were able to transactivate the G5E1B-CAT reporter gene; in contrast, p53 (Tyr-141) was not able to activate transcription. p53 (Tyr-141/His-273) behaved as a dominant negative mutant and inhibited the ability of the combination of p53 (His-273) and GAL4-p53 (C-terminus) to stimulate the reporter gene. Double immunoprecipitation by sequentially using GAL4 and p53 antibodies showed that p53 (His-273) and (Tyr-141/His-273), but not p53 (Tyr-141), can efficiently oligomerize in vivo to the C-terminal region of p53. Transcriptional activating function of p53 may be modulated by oligomerization; some mutations, such as His-273 and Trp-248, participate in these functions.(ABSTRACT TRUNCATED AT 400 WORDS)
Measuring containment of viable infectious cell sorting in high‐velocity cell sorters (2003)

With this monitoring system in place, aerosols can be efficiently measured, thus reducing the risk to the operator while sorting viable infectious cells.
Exothermic reactions in Co/Al nanolaminates (2008)

Vapor-deposited Co/Al nanolaminates having a net equiatomic stoichiometry exhibited rapid, high-temperature synthesis. When ignited locally, 7.5-μm-thick Co/Al foils were characterized by self-sustained propagating reactions with flame front speeds between ∼0.5 and 9 m/s. Speed was largely affected by bilayer thickness and premixed volume fraction, consistent with previous studies of other exothermic multilayers. Cobalt aluminide foils reacted by self-propagating synthesis developed a variety of rough surface morphologies characterized by a large amplitude (peak-to-valley ∼1.0 μm), multiperiod, wavelike structure. High-temperature reaction was also stimulated by rapid global heating. Tests revealed low ignition temperatures (Tig)∼240–460 °C compared with previous Co–Al powder reactant experiments. Ignition temperature was influenced by bilayer thickness. All foils ignited by global heating and those reacted in a self-propagating mode developed a single-phase B2 (CsCl-type) crystal structure. Thick Co/Al nanolaminates were used successfully to join a few different materials including metalized Al2O3 (by soldering) and polyetheretherketone (by direct attachment).
Lossless wavelet-based compression of digital elevation maps for fast and efficient search and retrieval (2005)

We consider here the implementation of efficient search and retrieval of digital elevation maps (DEMs), in particular the ability to conduct elevation searches without decompressing the entire map. We utilize set partitioning in hierarchical trees (SPIHT) for the compression, and compare two wavelet-based search and retrieval systems: one utilizing nonlinear max- and min-lifted integer wavelets and the other using the standard 5/3 integer wavelet. While the coarse-scale maxima/minima preservation inherent in the max- and min-lifted wavelets may seem ideal for the implementation of efficient elevation searches, the interscale propagation of maxima/minima and the bit-plane layering of the SPIHT coder adversely affect the efficiency of such searches. The use of the standard 5/3 integer wavelet requires the addition of separate maxima and minima information but does not have the complication of coefficient propagation, providing more satisfactory results. Elevation search bitrates are presented for both systems and compared to results obtained using the Kakadu implementation of the JPEG2000 standard.
Test structure for thermal monitoring (2002)

The paper is dealing with thermal test structures for CMOS ICs. A new temperature sensor/test structure is proposed: the Thermal Feedback Oscillator (TFO). Detailed design considerations are presented together with experimental results. Moreover the paper discusses general questions of the "design for thermal testability" (DfTT) principle including both the problems of placement of the test structures and possible solutions for the read-out of the test data.
Heart Rate Turbulence (2004)

Survivors of acute myocardial infarction are at increased risk of sudden cardiac death.It is crucial in the cardiac vascular domains that seeking a new powerful method for risk prediction.Now,professors study a new electrocardiologic predictor heart rate turbulence (HRT).They think that HRT is a sensitive and specific risk factor independent of the available stratifiers.There is a summary of this new index.
The search for inhibitors of interleukin-1 based on the sequence of interleukin-1 receptor antagonist. (1998)

In order to find the low-molecular-weight interleukin-1 (IL-1) inhibitors, we synthesised a series of peptides, derived from three regions of interleukin-1 receptor antagonist (IL-1ra): N-terminal (residues 5-9), central (90-98) and C-terminal (143-148). The decision was based on the thorough analysis of structural and functional properties of IL-1 proteins and the resemblance of some fragments of IL-1ra to well-known immunomodulators, like thymopentin and tuftsin. The competition between our peptides and IL-1 were measured as the inhibition of IL-1 induced IL-2 production in LBRM/CTLL cell line system. All peptides presented some activity, although the most interesting results (when the range of activity and dose-dependence were taken into account) were obtained for tuftsin and peptide VTKFYF from the C-terminal part of IL-1ra.