gebhart/patrepeval huggingface dataset:
Effect of Age and Other Factors on Maximal Heart Rate (1982)

Abstract In an attempt to reduce the confusion regarding reported effects of age upon maximal exercise heart rate (HR max), a comprehensive review of the English literature was conducted to obtain descriptive statistical data representing over 23,000 independent subjects from 5 to 81 years old. The data were split randomly into two data sets for independent regression analyses. HR max was the dependent variable while independent variables include: age, age2, age3, age4, sex, level of fitness, type of ergometer, exercise protocol, continent of residence, and race. After cross validation the data were pooled and reanalyzed. Additional validation was accomplished on identifiable subsets of the data, e.g., cross sectional, longitudinal, training, comparative ergometry, and comparative sex studies. Results identified negative linear and non-linear age factors, an ergometry factor, a fitness factor and a continent factor. Age accounted for about 70–75% of the variability. Generalized equations were proposed. Even with all factors accounted for, the 95% confidence interval of individual HR max was about 45 beats/min. Tables of HR max derived from the equations are included.
Constitutively unmasked CD22 on B cells of ST6Gal I knockout mice: novel sialoside probe for murine CD22 (2002)

The interaction of CD22 with glycoprotein ligands bearing the Siaalpha2,6Gal-R sequence is believed to modulate its function as a regulator of B cell signaling. Although a commercial sialoside-polyacrylamide (PAA) probe, NeuAc- alpha2,6Gal-PAA, has facilitated studies on ligand binding by human CD22, murine CD22 binds instead with high affinity to NeuGcalpha2,6Gal-R. A multivalent probe with this sequence was constructed to facilitate investigations of ligand binding in CD22 function using genetically defined murine models. The probe is based on the sialoside-PAA platform, which is then biotinylated for easy detection. A series of sialoside probes were constructed with two different length linker arms between the sialoside and the backbone and three different sialoside to PAA molar ratios. The NeuGcalpha2,6Gal-PAA probe is specific for CD22: it binds to sialidase-treated B cells of wild-type mice but not B cells of CD22-null mice. Additionally, because the probe only binds to sialidase-treated wild-type cells, it confirms that CD22 is constitutively "masked" on most B cells from wild-type mice by binding to ligands in cis. In contrast, the probe bound equally well to native or sialidase-treated B cells from the immunocompromised ligand-deficient ST6Gal I knockout mice, demonstrating that CD22 is constitutively "unmasked" in these cells.
L-Asparaginase Therapy for Leukemia and Other Malignant Neoplasms (1967)

Enzyme therapy directed at depletion of an amino acid, asparagine, indispensable for tumor cell growth but not required by normal tissues, offers a new and promising approach to the problem of treatment of leukemia and disseminated cancer. Therapy with the enzyme L-asparaginase in three cases of acute lymphatic leukemia resulted in measurable improvement in two advanced cases. In the third case, there was a striking response to large dosage, with rapid necrosis of lymph node masses and clearing of leukemic infiltrates. A laboratory test to detect dependency of tumor cells on asparagine seems helpful for selection of cases for investigation of therapy. Furthermore, a variety of human malignant diseases including acute lymphatic leukemia and acute and chronic granulocytic leukemia have been shown to be asparagine-dependent by this test. Exploitation of further possible nutritional differences offers a fertile field for investigation.
Optical Heterodyne Profilometer (1984)

An optical heterodyne profilometer breadboard with surface roughness measurement sensitivity to 0.1 A has been developed and demonstrated. Optical and electronic common-mode rejection techniques were employed in the optical heterodyne precision phase measurement scheme to resolve the optical phase to one part in thirty thousand. Vibration-induced optical phase jitter in the system was nearly eliminated by these common-mode rejection techniques. This noncontact profilometer is capable of characterizing mirror surfaces and is not limited only to flat and/or highly reflective surfaces. Con-cave surfaces, such as the x-ray mirrors for the Advanced X-ray Astrophysical Facility (AXAF), may be characterized as well. Several mirror samples, including two x-ray mirror samples, have been characterized with the optical heterodyne profilometer. Roughness measurement results for the x-ray mirror samples have been compared with those obtained by other methods.
Tracking Algorithm for GPS Offset Carrier Signals (1999)

A split-spectrum military signal seems a likely candidate
for future incorporation into L1 and/or L2. These split
signal modulations, often referred to as “Offset Carrier”
waveforms, present a technical challenge to the code
tracking capability of the receiver.
This paper describes a novel algorithm, which can be
used by a receiver to track the offset carrier signal. The
purpose of the algorithm is to resolve the ambiguity that
arises due to the multipeaked autocorrelation function of
the new signal, thus reducing false-lock probability. The
algorithm is defined, some aspects of its performance are
discussed, and simulation results are given.
Deriving Accurate Satellite Ballistic Coefficients from Two-Line Element Data (2012)

Covers advancements in spacecraft and tactical and strategic missile systems, including subsystem design and application, mission design and analysis, materials and structures, developments in space sciences, space processing and manufacturing, space operations, and applications of space technologies to other fields.
Voxel-based global illumination (2011)

Computing a global illumination solution in real-time is still an open problem. We introduce Voxel-based Global Illumination (VGI), a scalable technique that ranges from real-time near-field illumination to interactive global illumination solutions. To obtain a voxelized scene representation, we introduce a new atlas-based boundary voxelization algorithm and an extension to a fast ray-voxel intersection test. Similar to screen-space illumination methods, VGI is independent of the scene complexity. Using voxels for indirect visibility enables real-time near-field illumination without the screen-space artifacts of alternative methods. Furthermore, VGI can be extended to interactive, multi-bounce global illumination solutions like path tracing and instant radiosity.
Chemosystematic Value of Chemical Constituents from <i>Scabiosa hymettia</i> (Dipsacaceae) (2008)

The first phytochemical investigation of Scabiosa hymettia led to the isolation and characterization of nine known compounds, 2-10, and of the new kaempferol derivative 1. In total, two flavonoids, three coumarins, three iridoids, and two phenolic constituents were obtained. The chemosystematic value of these compounds, as well as the metabolic relationship between swertiamarin (6) and the other isolated coumarins, are discussed. Both the extracts as well as all isolated constituents of S. hymettia were evaluated for their antimicrobial activities against six Gram-positive or Gram-negative bacteria, and against three human pathogenic fungi. The new compound 1 was found to exhibit the highest activity against all organisms tested.
Postharvest Behaviour of Cut Tuberose Spikes as Affected by Chemicals (1998)

The experiments were conducted to study the effect of various chemicals, viz., boric acid, AL2 (SO4)3, CaCL2, AgNO3, CoCl2 and citric acid on postharvest life and quality of cut tuberose flowers. Among different concentrations used, boric acid (250 ppm), Al2 (SO4)3 (50 ppm), CaCL2 (1000 ppm), AgNO3 (50 ppm), CoCl2 (25 ppm) and citric acid (400 ppm) were found beneficial for improving opening of florets, flower diameter, useful life and longevity of spikes.
A Built-in-Test-based Reconfiguration Scheme for Wireless Systems for Increased Quality of Service (QoS) (2006)

Current wireless transceiver systems employ power-up self-calibration to enhance quality-of-service (QoS) for end-users. This is mostly performed by firmware (embedded software) within the digital signal processor (DSP) and automatic gain control (AGC) circuits in baseband. This self-calibration step by itself may not be effective to compensate for environmental effects. Moreover, these techniques consume significant battery power, often an undesirable attribute. In addition, aggressive technology scaling to nanometer regimes causes significantly larger process parameter variations compared to present manufacturing techniques. Unless compensated for, these process variations can set die specifications off the limits. In this paper, an online built-in-test (BIT) based compensation scheme has been proposed for RF front-end in wireless transceivers. The proposed approach is simple, involves minimal overhead, and is effective in improving the performance. Results indicate that a significant improvement in performance can be achieved after reconfiguration is performed.
Electroporation of cells (1990)

By measuring uptake of the membrane impermeable dye. phenosafranine, it can be shown that the plasma membrane of intact cells within cell aggregates can be reversibly permeabilized by electroporation. However, the plant cell wall is a barrier to DNA uptake by intact cells, although under certain circumstances expression of DNA, electroporated into intact cells, can be demonstrated. The level of expression is about 20–50 times lower than that obtained by electroporation of protoplasts, and depends on cell wall properties and pretreatments of cell aggregates. In contrast, efficient transformation of whole cells of bacteria and yeasts can be achieved by electroporation. Factors which influence DNA transfer into whole plant cells and the possibility of stable transformation are discussed.
Head and Neck Squamous Cell Carcinoma in Patients With Fanconi Anemia (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Otolaryngology–Head & Neck Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Otolaryngology–Head & Neck Surgery journal
Heat‐shock protein 70 modulates toxic extracellular α‐synuclein oligomers and rescues trans‐synaptic toxicity (2010)

The paradoxical appearance of aggregated α-synuclein (αsyn) in naive transplanted embryonic stem cells in Parkinson's disease (PD) brains has recently been reported, highlighting the possibility of neuron to neuron transmission of αsyn in PD. Here, we demonstrate in a cellular model the presence of αsyn oligomers in the extracellular space, their uptake by neurons, retrograde axonal transport to cell soma, and detrimental effects on neighboring cells. Moreover, we demonstrate that Hsp70 chaperones αsyn in the extracellular space and reduces extracellular αsyn oligomer formation and related toxicity. These novel findings provide evidence that extracellular αsyn oligomers may represent a crucial player in the propagation of pathology in PD, with their modulation by Hsp70 representing a potential new target for therapeutic interventions.
High Power Density Redox Flow Battery Cells (2013)

Redox flow batteries possess several key advantages that make them well suited for grid-scale energy-storage applications. However, the capital cost of flow batteries has been a major barrier to commercialization of this technology. One attractive path to cost reduction is the development of flow-battery cells with substantially higher power densities than conventional flow-battery cells. The cost of the cells comprises a significant portion of the total flow-battery system cost, especially at low production volumes, since cell parts are custom-built components. UTRC has developed high power density vanadium-redox battery cells utilizing a material set similar to conventional cells. This advanced cell technology can theoretically be applied to other flow-battery chemistries as well. This breakthrough in cell performance should motivate additional development of flow-battery technologies, since a realistic path to substantial cost reduction, which can be realized even at low production volumes, has now been demonstrated.
Fluorescent probe partitioning in giant unilamellar vesicles of ‘lipid raft’ mixtures (2010)

Direct visualization of raft-like l(o) (liquid-ordered) domains in model systems and cells using microscopic techniques requires fluorescence probes with known partitioning preference for one of the phases present. However, fluorescent probes may display dissimilar partitioning preferences in different lipid systems and can also affect the phase behaviour of the host lipid bilayer. Therefore a detailed understanding of the behaviour of fluorescent probes in defined lipid bilayer systems with known phase behaviour is essential before they can be used for identifying domain phase states. Using giant unilamellar vesicles composed of the ternary lipid mixture DOPC (1,2-dioleoyl-sn-glycero-3-phosphocholine)/DPPC (1,2-dipalmitoyl-sn-glycero-3-phosphocholine)/cholesterol, for which the phase behaviour is known, we examined nine commonly used fluorescent probes using confocal fluorescence microscopy. The partitioning preference of each probe was assigned either on the basis of quantification of the domain area fractions or by using a well-characterized l(d) (liquid-disordered)-phase marker. Fluorescent probes were examined both individually and using dual or triple labelling approaches. Most of the probes partitioned individually into the l(d) phase, whereas only NAP (naphtho[2,3-a]pyrene) and NBD-DPPE [1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-(7-nitro-2-1,3-benzoxadiazol-4-yl] preferred the l(o) phase. We found that Rh-DPPE (Lissamine rhodamine B-1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine) increased the miscibility transition temperature, T(mix). Interestingly, the partitioning of DiIC18 (1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate) was influenced by Bodipy-PC [2-(4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacene-3-pentanoyl)-1-hexa-decanoyl-sn-glycero-3-phosphocholine]. The specific use of each of the fluorescent probes is determined by its photostability, partitioning preference, ability to detect lipid phase separations and induced change in T(mix). We demonstrate the importance of testing a specific fluorescent probe in a given model membrane system, rather than assuming that it labels a particular lipid phase.
A Divide-and-Conquer Approach for Visual Odometry with Minimally-Overlapped Multi-Camera Setup (2014)

Pose estimation of a moving camera rig from the images alone has been investigated by the computer vision community for decades, because the location and direction information of the cameras are the basis for more advanced applications, such as 3D reconstruction and Simultaneous Localization and Mapping (SLAM). Visual Odometry (VO) is the accumulation of the relative pose estimation while the camera rig moves. There are some visual odometry methods for mono view, stereo, omnidirectional and multi-cameras that require additional sensor input(odometry, compass, e.g,) and/or synchronized cameras. However, in our Virtual Exercise Environment (VEE) system, and other low-cost multi-camera setups, none of the above methods can be applied. The Bundle Adjustment(BA) is the general approach for a non-regular case like the VEE system. BA puts all the known variables in one huge matrix and solves the unknowns at once with Levenberg-Marquardt iterations. Thus, the BA is computationally expensive in nature with the complexity of O(n3), and sometimes infeasible. In this thesis, I propose a `divide and conquer' approach that generates additional observations from consecutive images in neighboring camera pairs. I show this approach to solve the critical condition and drastically speed up pose estimation when compared to BA. The performance with different conditions and sub-algorithms are also tested and discussed.
Osteosarcoma originates from mesenchymal stem cells in consequence of aneuploidization and genomic loss of <i>Cdkn2</i> (2009)

High-grade osteosarcoma is characterized by extensive genetic instability, thereby hampering the identification of causative gene mutations and understanding of the underlying pathological processes. It lacks a benign precursor lesion and reports on associations with hereditary predisposition or germline mutations are uncommon, despite the early age of onset. Here we demonstrate a novel comprehensive approach for the study of premalignant stages of osteosarcoma development in a murine mesenchymal stem cell (MSC) system that formed osteosarcomas upon grafting. By parallel functional and phenotypic analysis of normal MSCs, transformed MSCs and derived osteosarcoma cells, we provide substantial evidence for a MSC origin of osteosarcoma. In a stepwise approach, using COBRA-FISH karyotyping and array CGH in different passages of MSCs, we identified aneuploidization, translocations and homozygous loss of the cdkn2 region as the key mediators of MSC malignant transformation. We then identified CDKN2A/p16 protein expression in 88 osteosarcoma patients as a sensitive prognostic marker, thereby bridging the murine MSCs model to human osteosarcoma. Moreover, occasional reports in patients mention osteosarcoma formation following bone marrow transplantation for an unrelated malignancy. Our findings suggest a possible hazard for the clinical use of MSCs; however, they also offer new opportunities to study early genetic events in osteosarcoma genesis and, more importantly, to modulate these events and record the effect on tumour progression. This could be instrumental for the identification of novel therapeutic strategies, since the success of the current therapies has reached a plateau phase.
A New generation natural gamma ray spectroscopy logging system (1996)

A new generation natural gamma ray spectroscopy logging service, Spectralog II, has been developed utilizing advanced data analysis methodology and calibration techniques to provide significantly improved measurements of formation potassium, uranium, and thorium. Such measurements are very useful for locating fracture zones, identifying clay and rock types, measuring bed thickness, and correlating zones of interest between wells in a field. The logging instrument contains a 2x12 inch CsI(Na) crystal and collects data at a speed of 9 m/min, three times the previously recommended rate, without loss of statistical precision. This provides valuable subsurface data while at the same time minimizing logging time within the well. Alternately, the service may be run at slower speeds in zones of major importance with extremely high precision.
Who, what, where & when (2008)

Mobile devices and the mobile Internet represent an extremely challenging search environment. Limited screenspace, restricted text-input and interactivity, and impatient users all conspire to exacerbate the shortcomings of modern Web search. Recently researchers have proposed that typically vague search queries be augmented by context information, as a way to help search engines to retrieve more relevant information. In this paper we propose a novel interface to support multi-dimensional, context-sensitive mobile search, combining context features such as location, time, and community preferences to offer a unique search experience that is well-adapted to the needs of mobile users.
Globally Synchronized Time via Datacenter Networks (2019)

Synchronized time is critical to distributed systems and network applications in a datacenter network. Unfortunately, many clock synchronization protocols in datacenter networks such as NTP and PTP are fundamentally limited by the characteristics of packet-switched networks. In particular, network jitter, packet buffering and scheduling in switches, and network stack overheads add non-deterministic variances to the round trip time, which must be accurately measured to synchronize clocks precisely. We present the Datacenter Time Protocol (DTP), a clock synchronization protocol that does not use packets at all, but is able to achieve nanosecond precision. In essence, the DTP uses the physical layer of network devices to implement a decentralized clock synchronization protocol. By doing so, the DTP eliminates most non-deterministic elements in clock synchronization protocols and has virtually zero protocol overhead since it does not add load at layer-2 or higher at all. It does require replacing network devices, which can be done incrementally and with very small amount of hardware resource consumption. We demonstrate that the precision provided by DTP in hardware is bounded by 4TD where D is the longest distance between any two nodes in a network in terms of number of hops and T is the period of the fastest clock. The precision can be further improved by combining DTP with frequency synchronization. By contrast, the precision of the state-of-the-art protocol (PTP) is not bounded: The precision is hundreds of nanoseconds in an idle network and can decrease to hundreds of microseconds in a heavily congested network.
N-Sulfonylbenzotriazoles. Part 2. Reactions of 1,1'-Sulfonyldibenzotriazole and 1-Benzenesulfonyl-1,2,4-triazole with Alcohols; A New Approach to N-Alkylbenzotriazoles and N-Alkyl-1,2,4-triazoles (1993)

1,l' Sulfonyldibenzotriazole (3) reacts with sodium alkoxides to give N-alkylbenzotriazoles.With alkanols, benzotriazolium alkyl sulfates are produced.I-Benzenesulfonyl-l,2,4-triazole with the sodium salts of alcohols gives 1-alkyl-1,2,4-triazoles.The mechanisms of these reactions are discussed.N,N1 -Thionyldiimidazole and N,Ni -sulfonyldiimidazole are useful sulfinyl and sulfonyl transfer reagents.Thus, N.Nf -thionyldiimidazole reacts exothermically with alcohols and phenols to form esters of sulfurous acid,' and with arylmagnesium halides to afford su~foxides;~ with carboxylic acids imidazolides are formed 4 at room temperature i n nearly quantitative yield evidently uia mixed anhydrides.N , N 1 - Sulfonyldiimidazole is less reactive than N,Nf -thionyldiimidazole; it has been used to prepare the 5 imidazolide of p-toluenesulfonic acid fromp-toluenesulfonic acid.Further applications of these two imidazole derivatives, and of the analogous benzimidazoles, in transfer reactions have been extensively studied.6-8The corresponding chemistry of the thionylated and sulfonylated benzotriazoles is far less known, although interest in them is growing due to the recognition of their biological importance and their increasing