gebhart/patrepeval huggingface dataset:
Temperature-Sensitive Europium(III) Probes and Their Use for Simultaneous Luminescent Sensing of Temperature and Oxygen (2006)

Highly photostable and strongly luminescent europium(III) beta-diketonate complexes are presented that can act as new probes for optical sensing of temperature. They can be excited with the light of a 405-nm LED and possess strong brightnesses. The decay times of the probes contained in a poly(vinyl methyl ketone) film and in poly(tert-butyl styrene) microparticles are highly temperature-dependent between 0 and 70 degrees C. The temperature-sensitive microparticles were dispersed, along with oxygen-sensitive microbeads consisting of a palladium porphyrin oxygen indicator in poly(styrene-co-acrylonitrile), in a thin layer of a hydrogel to give a dually sensing material which is excitable by a single light source. The two emissions can be separated by appropriate optical filters. The response to oxygen and temperature is described by 3D plots, and unbiased values can be obtained for temperature and oxygen, respectively, from the two luminescence signals if refined in an iteration step. The sensing scheme is intended for use in temperature-compensated sensing of oxygen, in contactless sensing of oxygen and temperature in (micro)biological and medical applications, in high-resolution oxygen profiling, and for simultaneous imaging of air pressure and temperature in wind tunnels.
Self‐Supervised Learning of Part Mobility from Point Cloud Sequence (2021)

Abstract Part mobility analysis is a significant aspect required to achieve a functional understanding of 3D objects. It would be natural to obtain part mobility from the continuous part motion of 3D objects. In this study, we introduce a self‐supervised method for segmenting motion parts and predicting their motion attributes from a point cloud sequence representing a dynamic object. To sufficiently utilize spatiotemporal information from the point cloud sequence, we generate trajectories by using correlations among successive frames of the sequence instead of directly processing the point clouds. We propose a novel neural network architecture called PointRNN to learn feature representations of trajectories along with their part rigid motions. We evaluate our method on various tasks including motion part segmentation, motion axis prediction and motion range estimation. The results demon strate that our method outperforms previous techniques on both synthetic and real datasets. Moreover, our method has the ability to generalize to new and unseen objects. It is important to emphasize that it is not required to know any prior shape structure, prior shape category information or shape orientation. To the best of our knowledge, this is the first study on deep learning to extract part mobility from point cloud sequence of a dynamic object.
Adipose-derived stem cells promote tumor initiation and accelerate tumor growth by interleukin-6 production (2015)

Adipose-derived stem cells (ADSCs) are multipotent cells that have attracted much recent attention. Here, we show that ADSCs enhance sphere formation and in vivo tumor initiation of breast and colon cancer cells. In co-culture, ADSCs induced several stem cell markers in cancer cells. ADSCs also accelerated tumor growth. Interaction of ADSCs and cancer cells stimulated secretion of interlukin-6 in ADSCs, which in turn acted in a paracrine manner on cancer cells to enhance their malignant properties. Interleukin-6 regulated stem cell-related genes and activated JAK2/STAT3 in cancer cells. We suggest that ADSCs may enhance tumor initiation and promotion.
Dextran-induced Agglutination of <i>Streptococcus mutans</i> , and Its Potential Role in the Formation of Microbial Dental Plaques (1969)

Glucose-grown washed cells of streptococci similar to Streptococcus mutans, which contain cell-bound dextransucrase, have been observed to agglutinate upon the addition of high molecular weight dextran. Low molecular weight dextran or unrelated polysaccharides were ineffective. Agglutination also occurred upon addition of sucrose, which can be converted into dextran, but not with other mono- and disaccharides. Other bacteria, including species capable of synthesizing dextrans, were not observed to exhibit this phenomenon. Cells of S. mutans agglutinated upon addition of dextran over a wide pH range, but maximal sensitivity to dextran occurred at pH 8.5. At this pH, such cells can be used for a simple, specific, and exquisitely sensitive qualitative assay for high molecular weight dextran, for addition of 6 ng of dextran with a molecular weight of 2 x 10(6) (i.e., approximately three molecules per cell) caused detectable agglutination. High concentrations of glucose, levan, and dextran of molecular weight of 2 x 10(4) inhibited the reaction. Fluorescein-labeled cells of S. mutans were observed to adhere to dextran-containing plaques and dextran-treated teeth, suggesting that this phenomenon may be of importance in the formation of streptococcal dental plaques. The mechanism responsible for dextraninduced agglutination appears to involve the affinity of a receptor site, possibly dextransucrase, on the surface of several cells for common dextran molecules.
Operational floating current conveyor: characteristics, modelling and applications (2002)

A new five-port general purpose analogue building block, termed as an operational floating current conveyor (OFCC), is described. The OFCC combines the features of current feedback (CFB) operational amplifier, second generation current conveyor and operational floating conveyor (OFC). A simple implementation scheme of the OFCC is described and its terminal operational characteristics are used to yield a working model. The OFCC is then used as a single block to realize the four main amplifier types and the current conveyors (CCII+ and CCII-). Computer simulation results are presented and discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Serrated Polyposis (2013)

Gastroduodenal polyps are uncommon and likely not associated with serrated polyposis. Although extracolonic tumors were common in our cohort, it is still unclear whether these are associated with serrated polyposis. Our data, along with previous studies, support an association between serrated polyposis and smoking. Further work is still needed to clarify the effect of smoking on polyp development/progression in serrated polyposis.
Modulation of biological phenotypes for tumor growth and metastasis by target-specific biological inhibitors in gastric cancer. (1999)

For tumor progression, a cascade of linked sequential biological events is essential. We tried to test whether biological therapy can modulate specific biological phenotypes and increase the anti-tumor effect when combined with chemotherapy. Five human gastric cancer cell lines (YCC-1, YCC-2, YCC-3, YCC-7, AGS) were used in these studies. Pentosan polysulfate (PPS) as a heparin-binding growth factor inhibitor, Tranexamic acid as a plasmin inhibitor, Lovastatin as an adhesion inhibitor and Adriamycin as a chemotherapeutic agent were selected. The effects of each drug on colony formation and tumor cell proliferation were evaluated by soft agar assay and cell proliferation assay, respectively to test direct anti-tumor effect. The expression of uPA, PAI-1 was determined by ELISA, while MMPs activity was evaluated by zymography. PPS suppressed the colony-forming activity as much as Adriamycin did, but it showed only cytostatic effects in cell proliferation assay. Migration capacity using Boyden chamber assay was more closely correlated with adhesive capacity than uPA or MMP-2 expression. The motility inhibitory effect of Tranexamic acid was observed in the YCC-7 cell line, which expressed all the required biological phenotypes for migration. In AGS, with high cell motility and adhesiveness, the adhesion was inhibited by Lovastatin and most of the inhibitory effect was recovered by Mevalonate. When PPS was combined with Adriamycin on the Adriamycin-resistant, midkine (MK) gene expressing YCC-7 cell line, the growth inhibition rate increased up to 84%, while that for a single treatment of PPS or Adriamycin was 40% and 22%, respectively (p=0.001). When we combined Tranexamic acid and Adriamycin, we observed the synergistic effect in YCC-3 and YCC-7, while no combined effect was found in YCC-1. The combination of Lovastatin and Adriamycin did not show any combined effects in any of the cell lines. In conclusion, a synergistic anti-proliferative effect (chemo-sensitization) with combined chemo-biotherapy was found in cancer cells with specific biological target, MK. The anti-motility effect was the greatest when the gastric cancer cells expressed all the specific biological phenotypes.
TLR9 Provokes Inflammation in Response to Fetal DNA: Mechanism for Fetal Loss in Preterm Birth and Preeclampsia (2012)

Preterm birth, the major cause of neonatal mortality in developed countries, is associated with intrauterine infections and inflammation, although the exact mechanisms underlying this event are unclear. In this study, we show that circulating fetal DNA, which is elevated in pregnancies complicated by preterm labor or preeclampsia, triggers an inflammatory reaction that results in spontaneous preterm birth. Fetal DNA activates NF-κB, shown by IκBα degradation in human PBMCs resulting in production of proinflammatory IL-6. We show that fetal resorption and preterm birth are rapidly induced in mice after i.p. injection of CpG or fetal DNA (300 μg/dam) on gestational day 10-14. In contrast, TLR9(-/-) mice were protected from these effects. Furthermore, this effect was blocked by oral administration of the TLR9 inhibitor chloroquine. Our data therefore provide a novel mechanism for preterm birth and preeclampsia, highlighting TLR9 as a potential therapeutic target for these common disorders of pregnancy.
Image matching based on epipolar and local homography constraints (2007)

An algorithm for image matching is proposed, which uses both epipolar and homography constraints. At the first step, the Forstner algorithm is employed for features extraction. The features description and matching method of SIFT are used to find a group of original correspondences, then the correspondences are refined by LSM(Least Square Matching). With the refined correspondences the RANSAC algorithm estimates the fundamental matrix robustly and the more accurate correspondences with less outliers are gotten, which are called as correspondences candidates. As the features extracted from the image are all the edge inflexions, texture nodes with maximal intensity or corners of the objects in the 3D world. The features which are adjacent can form a local plane or quasi-plane. So the homography constraint is proposed for image matching. At the second step, the corresponding features seeds around the feature to be matched are recognized from the correspondences, which associate with a real 3-D scene plane or quasi-plane. Then with the seed correspondences the local homography matrix is computed. At last, under the guide of the local homography matrix, the coarse position of the target feature on the opponent image is found, then with the constraints of the epipolar line and the coarse position, the normal correlation and LSM matching methods are employed to match the features accurately. The algorithm searches for the corresponding feature only in a very small region and works quickly. Experimental results show that the algorithm is efficient and it improves the robustness and accuracy of the automatic image matching.
Demonstration of complimentarity between monoclonal antibodies (MAbs) to human chorionic gonadotropin (hCG) and polyclonal antibodies to luteinizing hormone/hCG receptor (LH-R) and their use in better understanding hormone-receptor interaction. (1997)

We have earlier reported that polyclonal antisera raised in rabbits to a luteinizing hormone/chorionic gonadotropin receptor (LH-R) purified from sheep luteal tissue has antibodies exhibiting hormone agonistic and antagonistic activities. Western blot analysis showed this antibody (LHR-anti IgG) to be highly specific to sheep luteal LH receptor (LH-R) (Jeyakumar and Moudgal, 1991). Using this, along with a battery of mouse monoclonal antibodies (MAbs) to hCG, an attempt has been made to better understand the interaction of LH/hCG with its receptor. Of the eight hCG MAbs screened, three (B14/B7, B52/18 and A7/G4) were specific to the beta-subunit; while a second set of three (G10/F7, H9/E9 and B52/21) were specific to the alpha-subunit. Two additional MAbs (B52/28 and F9/G8) did not recognize individual subunits, but bound like the rest intact hCG. Both 125I hCG and 125I anti LHR-IgG bound specifically to ovine luteal membrane LH-R. Assuming that a certain degree of similarity should exist between hCG and LHR-anti IgG, different hCG MAbs were tested for their ability to block the binding of either 125I hCG or 125I LHR-anti IgG to sheep luteal LH-R. It appears that hCG and LH-R share a minimum of four sites that are complementary to each other and these are recognized by the hCG MAbs B14/B7, G10/F7, A7/G4, and H9/E9. Whereas two of the MAbs B14/B7 and G10/F7 blocked the binding of both 125I labeled hCG and LHR-anti IgG to the receptor, MAbs A7/G4 and H9/E9 only inhibited the binding of 125I LHR-anti IgG to the LH-R. Although individually B14/B7 and G10/F7 blocked the binding of 125I LHR-anti IgG to LH-R to a maximum extent of 43%, together they inhibited binding by as much as 80%. The ability of B14/B7 to inhibit binding of 125I LHR-anti IgG to the receptor was also significantly increased by the addition of A7/G4. Finally, by demonstrating direct binding of the immobilized hCG MAbs B14/B7, G10/F7, A7/G4, and H9/E9 to LHR-anti IgG, we have been able to establish that the receptor binding sites of hCG and LHR-anti IgG are complementary and that a set of four sites are recognizable by the hCG MAbs. From the degree of interaction, it appears that two sites recognized by MAbs B14/B7 and G10/F7 (representing a site each in the beta- and alpha-subunit of hCG) have a prominent role in the interaction of hCG with its receptor. Thus, this study has provided us with an opportunity to investigate the interaction of LH/hCG with its receptor by an indirect approach of monitoring the binding of their respective antibodies with each other.
A Phase I, Dose Escalation, Single Dose Trial of Oral Attenuated Salmonella typhimurium Containing Human IL-2 in Patients With Metastatic Gastrointestinal Cancers (2020)

Salmonella has been shown to preferentially colonize solid tumors. It is known that toxicity limits the systemic administration of immunomodulatory cytokines that have a significant anticancer effect. Therefore, we tested a unique cancer treatment strategy comprised of oral delivery of Saltikva, an attenuated strain of Salmonella typhimurium that contain the human gene for interleukin-2. In preclinical experimentation, a significant antitumor effect without toxicity was observed. A dose escalation, single dose, Phase I trial was conducted. Dose escalation (10 to 10) while monitoring for dose limiting toxicity and response was performed. Flow cytometry was conducted to determine the immunologic effect. In total 22 patients were administered Saltikva. Eight patients did not complete the trial. No toxicity or adverse events were observed. There was no survival advantage. Flow cytometry demonstrated an increase in circulating natural killer (NK) cells and NK-T cells when comparing the prestudy period. The results of this phase I dose escalation study show that oral attenuated S. typhimurium containing the human interleukin-2 gene caused no significant toxicities up to doses of 10 colony forming unit. There was no evidence of partial or complete response. All patients had progressive disease and eventually succumbed to their illness. Although no survival advantage was seen in this single dose study, the statistically significant increase in circulating NK and NK-T cell demonstrates an immunologic effect from this treatment regimen and suggest that a multiple dose study should be undertaken.
A handheld device for simultaneous detection of electrical and mechanical cardio-vascular activities with synchronized ECG and CW-Doppler Radar (2007)

This paper presents a handheld miniaturized sensor embodiment that allows simultaneous measurement of the electrical and related mechanical cardio-vascular activity. Mechanical motion is detected with a continuous wave Doppler radar sensor and interpreted with a synchronously detected ECG. The patient's posture and activity is measured using accelerometers. Challenges of the current technical approach are the positioning of the sensors, the influence of posture and the correct interpretation of the signals. The Doppler signals are compared with phonocardiography measurements, with a focus on the challenges of this technique. There is still research in an improved modeling of the sensor setup and signal interpretation required.
Automated determinations of dissolved organic carbon in lake water (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAutomated determinations of dissolved organic carbon in lake waterP. D. Goulden and Peter. BrooksbankCite this: Anal. Chem. 1975, 47, 12, 1943–1946Publication Date (Print):October 1, 1975Publication History Published online1 May 2002Published inissue 1 October 1975https://doi.org/10.1021/ac60362a040RIGHTS & PERMISSIONSArticle Views99Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (509 KB) Get e-Alerts Get e-Alerts
Ship positioning by matching radar images and map data (2014)

Satellite network based GPS system is the most accurate, accountable and practical method for determining geographical ship locations. However, GPS systems are not preferable since they are prone to external interferences, (ie, jammers). In this study, a method for determining ship positions by matching navigation or surveillance radar images and satellite images is introduced. For this purpose, an estimate for radar image is generated by a novel method using satellite or map image. Then, the estimated radar image is compared with the real radar image using cross correlation to generate a success rate. Then, this success rate is improved iteratively by updating estimated ship position. The algorithm was run with both simulated radar images and real radar images to evaluate the correctness of the estimated ship positions. The study results are promising in the sense that introduced algorithm can be industrialized after improvements.
Design and Experimental Analysis of Origami-Inspired Vibration Isolator With Quasi-Zero-Stiffness Characteristic (2017)

We present a prototype vibration isolator whose design is inspired by origami-based foldable cylinders with torsional buckling patterns. The vibration isolator works as a nonlinear spring that has quasi-zero spring stiffness in a given frequency region, where it does not transmit vibration in theory. We evaluate the performance of the prototype vibration isolator through excitation experiments via the use of harmonic oscillations and seismic-wave simulations of the Tohoku-Pacific Ocean and Kobe earthquakes. The results indicate that the isolator with the current specification is able to suppress the transmission of vibrations with frequencies of over 6 Hz. The functionality and constraints of the isolator are also clarified. It has been known that origami-based foldable cylinders with torsional buckling patterns provide bistable folding motions under given conditions. In a previous study, we proposed a vibration isolator utilizing the bistability characteristics and numerically confirmed the device's validity as a vibration isolator. Here, we attempt prototyping the isolator with the use of versatile metallic components and experimentally evaluate the isolation performance.
Keratin subtypes in carcinomas of the uterine cervix: implications for histogenesis and differential diagnosis. (1990)

Normal epithelia and carcinomas of the human uterine cervix were studied by monoclonal antibodies chain specific for cytokeratins 4, 8, 10, 13, 14, 18, and 19. Most cells in 13 examined squamous carcinomas revealed a cytokeratin phenotype detected in ectocervical basal cells and endocervical subcolumnar reserve cells: 8+, 14+, 18+, 19+, 4-, 10-, 13-. We propose that these two cell types are closely related or identical and that squamous carcinoma of the cervix originates in this cell type. In more differentiated tumor cells cytokeratins 4, 10, and 13, which are present in suprabasal layers of the normal ectocervical epithelium, were coexpressed with basal cell cytokeratins. Thus, contrary to previous beliefs, all cytokeratins detected in carcinomas were also present in normal epithelium of uterine cervix. The cytokeratin profile of cervical adenocarcinomas corresponded to that of columnar endocervical cells (8+, 18+, 19+), although two of the three adenocarcinomas also expressed cytokeratin 4, which in the normal endocervix was detected in scattered single columnar cells only. The new monoclonal antibody DE-K14, specific for cytokeratin 14, proved a specific marker of subcolumnar reserve cells in the endocervix. It was also the only one that reacted with all cervical squamous carcinomas but with none of the cervical adenocarcinomas and, as such, has a potential value for pathological differential diagnosis of cervical tumors.
A predominant-F/sub 0/ estimation method for CD recordings: MAP estimation using EM algorithm for adaptive tone models (2002)

This paper describes a predominant-F/sub 0/ (fundamental frequency) estimation method called PreFEst, which can detect melody and bass lines in monaural audio signals containing sounds of various instruments, While most previous methods premised mixtures of a few sounds and had difficulty dealing with such complex signals, our method can estimate the F/sub 0/ of the melody and bass lines without assuming the number of sound sources in compact-disc recordings. In this paper we propose the following three extensions to our previous PreFEst to make it more adaptive and flexible: introducing multiple harmonic-structure tone models, estimating the shape of tone models, and introducing a prior distribution of its shape and F/sub 0/ estimates These extensions were implemented by the MAP (maximum a posteriori probability) estimation by using the expectation-maximization algorithm. Experimental results with compact-disc recordings showed that our real-time system based on the extended PreFEst achieved performance improvement.
Review (1984)

Law and State in Papua New Guinea . By Peter Fitzpatrick. Academic Press, London, 1980. Pp. 290. Price: $29.00.