gebhart/patrepeval huggingface dataset:
STAFF ASSESSMENT: THE DEVELOPMENT OF PROCEDURES FOR AUSTRALIAN UNIVERSITIES (1988)

ABSTRACT In Australia, a recent Review of Efficiency and Effectiveness in Tertiary Education (Hudson, 1986) has produced an interest in formal staff appraisal schemes designed to assess performance of academic staff members for feedback and decision‐making purposes. This paper outlines five principles which seem, after review of the literature on staff assessment schemes in the USA, to be important for the development of valid and reliable staff evaluation schemes. While the suggestions for Australian universities which have been made by the recent report are compatible with some of these principles, other principles are clearly violated, even in the sketchy outline of the scheme which has appeared to date. It is suggested that these principles need to be emphasised once again in the hope that the Australian universities are able to gain from experiences which exist in the literature to date.
Quantifying Losses in Open-Circuit Voltage in Solution-Processable Solar Cells (2015)

To compare and improve solar cells, merely knowing their percent efficiencies is insufficient; we need to be able to understand and quantify their different physical mechanisms of loss. The authors use the reciprocity relation between light absorption and emission to explore theoretical and practical performance limits for emerging technologies based on organics and perovskites, and compare them to state-of-the-art systems based on GaAs, c-Si, and CIGS. This study indicates the potential of the newer technologies, and shows the factors that limit present-day performance.
Scanning with magnetoresistive sensors for subsurface corrosion (2002)

I present examples of scans of various corrosion standards and an airliner sample using the new high performance magentoresistive (MR) sensors. These sensors are more sensitive than the standard pick up coils, and can operate at lower frequencies, thus permitting deeper penetration. Examples of scans using a single sensor, and an 8-element array are shown and discussed. I also describe the configuration of the sensors and the means of excitation the induced eddy currents, and discuss the various ways in which these sensitive devices can be exploited for use in non-destructive evaluation (NDE).
Biocompatible Ossicular Implants (1978)

Proplast and Plastipore, two new biocompatible implant materials that encourage tissue ingrowth, were used in 225 tympanoplasties. A 12 to 28-month follow-up shows that in 133 tympanoplasties using a drum-to-footplate or total ossicular replacement prosthesis (TORP), there was an average air conduction gain of 19 dB and 65% closure of the air-bone gap to within 20 dB. In 17 tympanoplasties using a drum-to-stapes or partial ossicular replacement prosthesis (PORP), there was an average air conduction gain of 20 dB and 100% closure of the air-bone gap. In 53 tympanoplasties/mastoidectomies using a TORP, there was an average air conduction gain of 19 dB and 87% closure of the air-bone gap. In 22 tympanoplasties mastoidectomies using a PORP, there was an average air conduction gain of 25 dB and 100% closure of the air-bone gap. Five (2.2%) of the 225 Plastipore prostheses have extruded.
Laminar Silk Scaffolds for Aligned Tissue Fabrication (2012)

3D-biomaterial scaffolds with aligned architecture are of vital importance in tissue regeneration. A generic method is demonstrated to produce aligned biomaterial scaffolds using the physics of directional ice freezing. Homogeneously aligned 3D silk scaffolds with high porosity and alignment are prepared. The method can be adapted to a wide range of polymers and is devoid of any chemical reactions, thus avoiding potential complications associated with by-products. Mechanical properties and cellular responses with chondrocytes and bone-marrow-derived hMSCs are studied, assessing survival, proliferation, and differentiation. In vivo tests suggest biocompatibility of the matrices for future tissue engineering applications, specifically in areas where high cellular alignment is needed.
Energization of the transport systems for arabinose and comparison with galactose transport in <i>Escherichia coli</i> (1981)

1. Strains of Escherichia coli were obtained containing either the AraE or the AraF transport system for arabinose. AraE+,AraF- strains effected energized accumulation and displayed an arabinose-evoked alkaline pH change indicative of arabinose-H+ symport. In contrast, AraE-,AraF+ strains accumulated arabinose but did not display H+ symport. 2. The ability of different sugars and their derivatives to elicit sugar-H+ symport in AraE+ strains was examined. Only L-arabinose and D-fucose were good substrates, and arabinose was the only inducer. 3. Membrane vesicles prepared from an AraE+,AraF+ strain accumulated the sugar, energized most efficiently by the respiratory substrates ascorbate + phenazine methosulphate. Addition of arabinose or fucose to an anaerobic suspension of membrane vesicles caused an alkaline pH change indicative or sugar-H+ symport on the membrane-bound transport system. 4. Kinetic studies and the effects of arsenate and uncoupling agents in intact cells and membrane vesicles gave further evidence that AraE is a low-affinity membrane-bound sugar-H+ symport system and that AraF is a binding-protein-dependent high-affinity system that does not require a transmembrane protonmotive force for energization. 5. The interpretation of these results is that arabinose transport into E. coli is energized by an electrochemical gradient of protons (AraE system) or by phosphate bond energy (AraF system). 6. In batch cultures the rates of growth and carbon cell yields on arabinose were lower in AraE-,AraF+ strains than in AraE+,AraF- or AraE+,AraF+ strains. The AraF system was more susceptible to catabolite repression than was the AraE system. 7. The properties of the two transport systems for arabinose are compared with those of the genetically and biochemically distinct transport systems for galactose, GalP and MglP. It appears that AraE is analogous to GalP, and AraF to MglP.
THE ACTION OF INDORAMIN AND OTHER COMPOUNDS ON THE UPTAKE OF NEUROTRANSMITTERS INTO RAT CORTICAL SLICES (1974)

Indoramin has been tested for its ability to inhibit the uptake of tritiated (-)-noradrenaline and 5-hydroxytryptamine into rat brain cortical slices. Other alpha-blocking agents and tricycic antidepressants were included for comparison. Activity against noradrenaline uptake is probably not important in the therapeutic action of indoramin. However, inhibition of 5-hydroxytryptamine uptake may be responsible for the sedation in high dosage noted by some investigators,
Effects of dietary flax seed and sunflower seed supplementation on normal canine serum polyunsaturated fatty acids and skin and hair coat condition scores (2001)

This prospective study involved supplementing 18 normal dogs with flax seed (FLX) and sunflower seed (SUN) and evaluating their effects on skin and hair coat condition scores and serum polyunsaturated fatty acids (PUFA) concentrations. Skin and hair coat were evaluated in a double-blinded fashion using a numeric scoring system and serum PUFA concentrations were determined. Our hypothesis was that changes in serum PUFA concentrations are associated with improvements in skin and hair coat and that serum PUFA would provide an objective method for making dietary fatty acid supplement recommendations. Although a numerical improvement was found in hair coat quality in both groups, this improvement was not sustained beyond 28 days. The relative per cent of 18:3n-3 concentrations in serum phospholipids increased in the FLX treated dogs but these concentrations remained unchanged in the SUN treated dogs. Also, elevations in relative per cent of 18:2n-6 concentrations in serum phospholipids were seen in the FLX group. The ratio of serum polyunsaturated to saturated fatty acids also showed a transient increase. These increases preceded the peak skin condition score peak value by approximately 14 days. It was concluded that a 1-month supplementation with either flax seed or sunflower seed in dogs provides temporary improvement in skin and hair coat. These changes appeared to be associated with increased serum 18 carbon PUFA.
GROWTH, SIZE AND REPRODUCTION IN <i>DAPHNIA</i> (CRUSTACEA: CLADOCERA)* (1956)

Factors influencing the growth of Daphnia are summarized; it is shown that lack of oxygen inhibits the growth of Daphnia magna. Synchronization of egg laying by females in samples from natural populations has been found on several occasions. The pre‐adult growth of Daphnia has been studied by rearing 207 specimens belonging to eight species in standard conditions. The greatest growth increment does not always occur at the end of the adolescent instar; it may occur at the end of the pre‐adolescent instar or more rarely even earlier. Initial size influences the instar in which maturity is reached; as the initial size increases the animals tend to become mature in earlier instars. In single samples from natural populations a direct correlation has been found between the size of the females and the number of eggs carried in their brood pouches. This applies to several species of Daphnia and certainother Cladocera (excluding the subfamily Chydorinae). Synchronous fluctuations in the size of parthenogenetic females and the number of eggs in their brood pouches have been found in a population of D. magna. Factors influencing the size of eggs and young are analysed. Within a species the following factors are operative: egg number in relation to the size of the mother, the age of the mother, inherited racial or clonal characteristics, available food and temperature. The size of the ephippial eggs of D. magna varies with the size of the female producing them. The ephippial eggs may be bigger or smaller than the parthenogenetic eggs. The eggs of thirty‐three species of Cladocera have been measured. The larger species produce eggs which are slightly larger in relation to maternal size than those of the smaller species. A mature female of D. magna can assimilate enough material during each instar to produce eggs with a dry weight at least equal to that of her body after the eggs have been laid. The dry weight of the parthenogenetic egg of D. magna diminishes by 16 to 25 per cent during embryonic development.
Superficial and orthovoltage x-ray beam dosimetry (1998)

Output of superficial and orthovoltage x-ray units may be measured with cylindrical or end-window parallel-plate ionization chambers. The air-kerma calibration factors for these chambers are usually determined free in air, and the x-ray machine output is stated as the air-kerma rate free in air, which, when multiplied with the appropriate backscatter factor, gives the air-kerma rate on the surface of a phantom or patient. For end-window chambers, especially when they are used for measurements of small fields or low x-ray energies, the air-kerma calibration factors may also be determined with the chamber embedded in a tissue-equivalent phantom. This results in field size dependent air-kerma in-air calibration factors but obviates the requirement for knowledge of back-scatter factors when determining the air-kerma rate on the surface of a phantom. Since there still is considerable uncertainty in tabulated backscatter factors as a function of field size and x-ray beam energy, the output measurement technique which determines the air-kerma rate on phantom surface with a phantom-embedded end-window ionization chamber offers a clear advantage over the in-air calibration method.
Morphology‐Directed Selective Production of Ethylene or Ethane from CO<sub>2</sub> on a Cu Mesopore Electrode (2016)

The electrocatalytic conversion of CO<sub>2</sub> to value-added hydrocarbons is receiving significant attention as a promising way to close the broken carbon-cycle. While most metal catalysts produce C<sub>1</sub> species, such as carbon monoxide and formate, the production of various hydrocarbons and alcohols comprising more than two carbons has been achieved using copper (Cu)-based catalysts only. Methods for producing specific C<sub>2</sub> reduction outcomes with high selectivity, however, are not available thus far. Herein, the morphological effect of a Cu mesopore electrode on the selective production of C<sub>2</sub> products, ethylene or ethane, is presented. Cu mesopore electrodes with precisely controlled pore widths and depths were prepared by using a thermal deposition process on anodized aluminum oxide. With this simple synthesis method, we demonstrated that C<sub>2</sub> chemical selectivity can be tuned by systematically altering the morphology. Supported by computational simulations, we proved that nanomorphology can change the local pH and, additionally, retention time of key intermediates by confining the chemicals inside the pores.
Ct Image Labeling Using Simulated Annealing Algorithm (1998)

Publication in the conference proceedings of EUSIPCO, Rhodes, Greece, 1998
I-Ad restricted T cell recognition of influenza hemagglutinin. Synthetic peptides identify multiple epitopes corresponding to antibody-binding regions of the HA1 subunit. (1989)

In a recent study, we reported extensive diversity in the Iak-restricted T cell repertoire for the hemagglutinin molecule (HA) of influenza A viruses (H3 subtype). Synthetic peptides identified six nonoverlapping epitopes on the HA1 subunit, and CD4+ T cell clones, specific for these regions, discriminated between natural variant viruses that had accumulated amino acid substitutions during antigenic drift. Here, we demonstrate similar specificity and diversity for the Iad haplotype and have identified multiple T cell epitopes within the sequences HA1 56-76, 71-91, 81-97, 177-199, 186-205, and 206-227. These also include recognition sites for neutralizing antibodies and correlations can be made between antigenic drift substitutions in H3 subtype viruses and the specificity of individual CD4+ clones for mutant HA. Moreover, these peptides appear not to exhibit structural homology and fail to compete for Ag presentation, indicating heterogeneity in peptide-Ia interaction. To explain the observation that CD4+ T cells, from two major haplotypes, recognize antibody binding regions of the HA molecule, we propose that surface Ig receptors of the Ag-specific B memory cell exert a direct effect on the processing of HA peptides and subsequent selection of the class II-restricted T cell memory repertoire after natural infection.
Acute myeloid leukemia with mutated nucleophosmin 1: an immunogenic acute myeloid leukemia subtype and potential candidate for immune checkpoint inhibition (2017)

Clinical and preclinical data suggest that acute myeloid leukemia (AML) with mutated nucleophosmin 1 ( NPM1 mut) might constitute an immunogenic leukemia subtype. In general, AML with NPM1 mut correlates with better prognosis, but the underlying mechanisms still remain to be elucidated. Our group
Human Rhinovirus 16 Causes Golgi Apparatus Fragmentation without Blocking Protein Secretion (2014)

The replication of picornaviruses has been described to cause fragmentation of the Golgi apparatus that blocks the secretory pathway. The inhibition of major histocompatibility complex class I upregulation and cytokine, chemokine and interferon secretion may have important implications for host defense. Previous studies have shown that disruption of the secretory pathway can be replicated by expression of individual nonstructural proteins; however the situation with different serotypes of human rhinovirus (HRV) is unclear. The expression of 3A protein from HRV14 or HRV2 did not cause Golgi apparatus disruption or a block in secretion, whereas other studies showed that infection of cells with HRV1A did cause Golgi apparatus disruption which was replicated by the expression of 3A. HRV16 is the serotype most widely used in clinical HRV challenge studies; consequently, to address the issue of Golgi apparatus disruption for HRV16, we have systematically and quantitatively examined the effect of HRV16 on both Golgi apparatus fragmentation and protein secretion in HeLa cells. First, we expressed each individual nonstructural protein and examined their cellular localization and their disruption of endoplasmic reticulum and Golgi apparatus architecture. We quantified their effects on the secretory pathway by measuring secretion of the reporter protein Gaussia luciferase. Finally, we examined the same outcomes following infection of cells with live virus. We demonstrate that expression of HRV16 3A and 3AB and, to a lesser extent, 2B caused dispersal of the Golgi structure, and these three nonstructural proteins also inhibited protein secretion. The infection of cells with HRV16 also caused significant Golgi apparatus dispersal; however, this did not result in the inhibition of protein secretion. Importance: The ability of replicating picornaviruses to influence the function of the secretory pathway has important implications for host defense. However, there appear to be differences between different members of the family and inconsistent results when comparing infection with live virus to expression of individual nonstructural proteins. We demonstrate that individual nonstructural HRV16 proteins, when expressed in HeLa cells, can both fragment the Golgi apparatus and block secretion, whereas viral infection fragments the Golgi apparatus without blocking secretion. This has major implications for how we interpret mechanistic evidence derived from the expression of single viral proteins.
Should parents log onto the net? (2000)

THE world can be a harsh place for working parents. They may leave home early in the morning, drop their child at daycare and in some extreme cases, do not see them until late into the evening.
Multidimensional high performance liquid chromatography - capillary electrophoresis separation of a protein digest: An update (2001)

The trypsin digest of a mixture of two proteins, namely cytochrome c and myoglobin, was first separated in the first dimension by high-performance liquid chromatography (HPLC). Fractions from the HPLC were collected every 30s with the aid of a fraction collector into a 96-well microtiter plate. After concentration, all the collected fractions were analyzed simultaneaosly in the second dimension by a 96-array capillary electrophoresis system. The labeled peptides were detected by laser-induced fluorescence. An internal standard, allura red, was added to all the fractions, prior to capillary electrophoretic analysis. The internal standard serves two functions, migration time correction and signal intensity correction. The data are presented in two different formats, as an electropherogram of all the fractions and in a two-dimensional (2-D) format. The 2-D plot of the data shows the density of each spot, which corresponds to the concentration of the migrating peptides. The total experimental time for the HPLC and capillary electrophoretic analyses ist less than 1 h, which ist much faster than using 2-D slab-gel electrophoresis or single-capillary capillary electrophoresis.
Assessment of super-resolution for face recognition from very-low resolution images (2009)

Super-Resolution (SR) involves the registration of multiple images/frames and reconstruction of a single higher resolution image. The goal of this research is to use multiple, very-low resolution images, such as those produced from a video sequence in a wireless sensor network system, as input to the super-resolution process in a face recognition system. The algorithm used for face recognition is the Fisherfaces method with a nearest neighbor classifier used for the recognition decision. Superresolution consists of two stages, a registration stage and a reconstruction stage. The testing images were segmented using a simple skin color detection approach. After the cropping, the images were combined into groups of four from a sliding window that would take the current image and the following three images repeating this process by moving to the next image in the sequence and the subsequent three images until the end of the current class, or person, is reached. This same sliding window was used for the super-resolution algorithm using faces from the three people or classes. Each group of four images was used as an input to the Keren registration algorithm where the rotational and translation information was saved that was then entered into the robust super-resolution reconstruction algorithm to create a single high quality image, which was processed by the face recognition algorithm. The methods tested to compare were the average of the same groups of four, the centroid shifted average and the minimum of the four faces in the group. The comparison was based on nearest neighbor classifier and on classification rates. The results were not in favor of the super-resolution method but instead, the centroid shifted average was the best in this study.
Multi‐input <scp>CRISPR</scp> / <scp>C</scp> as genetic circuits that interface host regulatory networks (2014)

Genetic circuits require many regulatory parts in order to implement signal processing or execute algorithms in cells. A potentially scalable approach is to use dCas9, which employs small guide RNAs (sgRNAs) to repress genetic loci via the programmability of RNA:DNA base pairing. To this end, we use dCas9 and designed sgRNAs to build transcriptional logic gates and connect them to perform computation in living cells. We constructed a set of NOT gates by designing five synthetic Escherichia coli σ70 promoters that are repressed by corresponding sgRNAs, and these interactions do not exhibit crosstalk between each other. These sgRNAs exhibit high on-target repression (56- to 440-fold) and negligible off-target interactions (< 1.3-fold). These gates were connected to build larger circuits, including the Boolean-complete NOR gate and a 3-gate circuit consisting of four layered sgRNAs. The synthetic circuits were connected to the native E. coli regulatory network by designing output sgRNAs to target an E. coli transcription factor (malT). This converts the output of a synthetic circuit to a switch in cellular phenotype (sugar utilization, chemotaxis, phage resistance).
COX-2: a link between airway inflammation and disordered chloride secretion in cystic fibrosis? (2006)

bronchodilator compared with a group receiving placebo. 9 By the end of the training programme, the duration of a constant work rate treadmill task was increased by 79% in patients receiving bronchodilator treatment compared with those receiving placebo.
Novel strategy for measuring creatine kinase reaction rate in the in vivo heart (2009)

In the heart, the creatine kinase (CK) system plays an important role in the cascade of ATP production, transportation, and utilization. The forward pseudo-first-order rate constant for the CK reaction can be measured noninvasively by the (31)P-magnetic resonance (MR) spectroscopy magnetization saturation transfer (MST) techniques. However, the measurement of MST in the in vivo heart is limited by the lengthy data acquisition time, especially for studies requiring spatial localization. This technical report presents a new method for measuring ATP production rate via CK that can reduce the MST data acquisition time by 82%. This method is validated using an in vivo pig model to evaluate the forward pseudo-first-order rate constant of myocardial CK reaction noninvasively.