gebhart/patrepeval huggingface dataset:
Synthesis of Palladium Nanoparticles by Sonochemical Reduction of Palladium(II) Nitrate in Aqueous Solution (2005)

The sonochemical synthesis of stable palladium nanoparticles has been achieved by ultrasonic irradiation of palladium(II) nitrate solution. The starting solutions were prepared by the addition of different concentrations of palladium(II) nitrate in ethylene glycol and poly(vinylpyrrolidone) (PVP). The resulting mixtures were irradiated with ultrasonic 50 kHz waves in a glass vessel for 180 min. The UV-visible absorption spectroscopy and pH measurements revealed that the reduction of Pd(II) to metallic Pd has been successfully achieved and that the obtained suspensions have a long shelf life. The protective effect of PVP was studied using Fourier transform infrared (FT-IR) spectroscopy. It has been found that, in the presence of ethylene glycol, the stabilization of the nanoparticles results from the adsorption of the PVP chain on the palladium particle surface via the coordination of the PVP carbonyl group to the palladium atoms. The effect of the initial Pd(II) concentration on the Pd nanoparticle morphology has been investigated by transmission electron microscopy. It has been shown that the increase of the Pd(II)/PVP molar ratio from 0.13 x 10(-3) to 0.53 x 10(-3) decreases the number of palladium nanoparticles with a slight increase in particle size. For the highest Pd(II)/PVP value, 0.53 x 10(-3), the reduction reaction leads to the unexpected smallest nanoparticles in the form of aggregates.
Natural Language Generation for dialogue: system survey (2003)

Many natural language dialogue systems make use of `canned text' for output generation. This approach may be su±cient for dialogues in restricted domains where system utterances are short and simple and use fixed expressions (e.g., slot filling dialogues in the ticket reservation or travel information domain); but for more sophisticated dialogues (e.g., tutoring dialogues) a more advanced generation method is required. In such dialogues, the system utterances should be produced in a context-sensitive fashion, for instance by pronominalising anaphoric references, and by using more or less elaborate wording depending on the state of the dialogue, the expertise of the user, etc. In the case of spoken dialogues, it is very useful if the natural language generation component can provide information that is relevant for determining the prosody of the speech output. Similarly, for use in embodied agents it is useful if the generation component can provide information about the facial and body movements that should accompany the language being produced by the agent. Clearly, it will be extremely di±cult to achieve all this using simple string manipulation, so a more flexible and context-sensitive generation method is required. This report discusses some of the possibilities for the sophisticated generation of system utterances in a dialogue system. The basic assumption is that this task is performed by a separate language generation module, which takes as its input a message specification produced by a dialogue planner and transforms this message into an expression in natural language. Part I of this report provides a general discussion of different methods for performing this task, and outlines some requirements on language generation systems that might be used for this purpose. Part II gives an overview of publicly available language generation systems, and discusses to what extent they meet the previously stated requirements.
Quantitative Proteomic Analysis of Cellular Protein Modulation upon Inhibition of the NEDD8-Activating Enzyme by MLN4924 (2011)

Cullin-RING ubiquitin ligases (CRLs) are responsible for the ubiquitination of many cellular proteins, thereby targeting them for proteasomal degradation. In most cases the substrates of the CRLs have not been identified, although many of those that are known have cancer relevance. MLN4924, an investigational small molecule that is a potent and selective inhibitor of the Nedd8-activating enzyme (NAE), is currently being explored in Phase I clinical trials. Inhibition of Nedd8-activating enzyme by MLN4924 prevents the conjugation of cullin proteins with NEDD8, resulting in inactivation of the entire family of CRLs. We have performed stable isotope labeling with amino acids in cell culture analysis of A375 melanoma cells treated with MLN4924 to identify new CRL substrates, confidently identifying and quantitating 5122-6012 proteins per time point. Proteins such as MLX, EID1, KLF5, ORC6L, MAGEA6, MORF4L2, MRFAP1, MORF4L1, and TAX1BP1 are rapidly stabilized by MLN4924, suggesting that they are novel CRL substrates. Proteins up-regulated at later times were also identified and siRNA against their corresponding genes were used to evaluate their influence on MLN4924-induced cell death. Thirty-eight proteins were identified as being particularly important for the cytotoxicity of MLN4924. Strikingly, these proteins had roles in cell cycle, DNA damage repair, and ubiquitin transfer. Therefore, the combination of RNAi with stable isotope labeling with amino acids in cell culture provides a paradigm for understanding the mechanism of action of novel agents affecting the ubiquitin proteasome system and a path to identifying mechanistic biomarkers.
Cardiopatch platform enables maturation and scale-up of human pluripotent stem cell-derived engineered heart tissues (2017)

Despite increased use of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) for drug development and disease modeling studies, methods to generate large, functional heart tissues for human therapy are lacking. Here we present a "Cardiopatch" platform for 3D culture and maturation of hiPSC-CMs that after 5 weeks of differentiation show robust electromechanical coupling, consistent H-zones, I-bands, and evidence for T-tubules and M-bands. Cardiopatch maturation markers and functional output increase during culture, approaching values of adult myocardium. Cardiopatches can be scaled up to clinically relevant dimensions, while preserving spatially uniform properties with high conduction velocities and contractile stresses. Within window chambers in nude mice, cardiopatches undergo vascularization by host vessels and continue to fire Ca<sup>2+</sup> transients. When implanted onto rat hearts, cardiopatches robustly engraft, maintain pre-implantation electrical function, and do not increase the incidence of arrhythmias. These studies provide enabling technology for future use of hiPSC-CM tissues in human heart repair.
An effective memory-processor integrated architecture for computer vision (2002)

In this paper an effective memory-processor integrated architecture, called memory based processor array (MPA), for computer vision is proposed. The MPA can be easily attached into any host system via memory interface. In order to measure the impact of the memory interface structure an analytical model is derived. The performance improvement on the proposed model for the memory interface architecture of the MPA system can be 6%/spl sim/40% for vision tasks consisting of sequential and data parallel tasks. The asymptotic time complexities of the mapping algorithms are evaluated to verify the cost-effectiveness and the efficiency of the MPA system.
Synovial Chlamydia trachomatis in patients with reactive arthritis/Reiter's syndrome are viable but show aberrant gene expression. (1998)

Synovial chlamydia are viable/metabolically active, since primary rRNA transcripts and mRNA from chlamydial genes specifying components of the bacterial protein synthetic system were present in most patient samples assayed. Expression of omp1, encoding the major outer membrane protein, is strongly attenuated in persistently infecting synovial chlamydia, while that of hsp60, specifying a highly immunogenic heat shock protein of the organism, is not downregulated.
InGaN Light-Emitting Diodes on<i>c</i>-Face Sapphire Substrates in Green Gap Spectral Range (2013)

High-efficiency InGaN light-emitting diodes (LEDs) in the "green gap" range were fabricated on c-face sapphire (0001) substrates. Optical properties were enhanced by band engineering of active layers and optimization of growth conditions. Output power and external quantum efficiency of 11.0 mW and 24.7% for a 559 nm green-yellow LED and 4.7 mW and 13.3% for a 576 nm yellow LED with the injection current of 20 mA were achieved, respectively.
Buried Layer Engineering to Reduce the Drain-Induced Barrier Lowering of Sub-0.05 µm SOI-MOSFET (1999)

The influence of the buried layer structure on the drain-induced barrier lowering (DIBL) is investigated for a silicon-on-insulator metal-oxide-silicon field-effect-transistor (SOI-MOSFET) by a two-dimensional device simulator. The buried layer thickness and the dielectric constant of the buried layer are varied systematically. It is found that the degradation on the threshold voltage can be separated into two components. One component originates from the electric flux via the SOI layer and the other via the buried layer. The buried insulator engineering which controls the thickness and the dielectric constant of the buried layer is effective in reducing the latter component. The gate length limit can be reduced by 23% by the buried air gap structure where the dielectric constant of the buried layer is 1.0.
Three Dimensional Gradient Magnetics — Geologic Applications (1999)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1999Three Dimensional Gradient Magnetics — Geologic ApplicationsAuthors: Terence J. McConnellBob LoAlastair Ryder‐TurnerZeev BergerTerence J. McConnellScintrex Limited, Bob LoScintrex Limited, Alastair Ryder‐TurnerScintrex Limited, and Zeev BergerImage Interpretation Technologies Inc.https://doi.org/10.1190/1.1821034 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1821034FiguresReferencesRelatedDetailsCited ByEuler deconvolution of the analytic signals of the gravity gradient tensor for the horizontal pipeline of finite length by horizontal cylinder calculation16 February 2017 | Journal of Geophysics and Engineering, Vol. 14, No. 2 SEG Technical Program Expanded Abstracts 1999ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1999 Pages: 2061 publication data© 1999 Copyright © 1999 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 04 Jan 2005 CITATION INFORMATION Terence J. McConnell, Bob Lo, Alastair Ryder‐Turner, and Zeev Berger, Dr., (1999), "Three Dimensional Gradient Magnetics — Geologic Applications," SEG Technical Program Expanded Abstracts : 398-399. https://doi.org/10.1190/1.1821034 Plain-Language Summary PDF DownloadLoading ...
Dual-Color Fluorescence Imaging of Magnetic Nanoparticles in Live Cancer Cells Using Conjugated Polymer Probes (2016)

Rapid growth in biological applications of nanomaterials brings about pressing needs for exploring nanomaterial-cell interactions. Cationic blue-emissive and anionic green-emissive conjugated polymers are applied as dual-color fluorescence probes to the surface of negatively charged magnetic nanoparticles through sequentially electrostatic adsorption. These conjugated polymers have large extinction coefficients and high fluorescence quantum yield (82% for PFN and 62% for ThPFS). Thereby, one can visualize trace amount (2.7 μg/mL) of fluorescence-labeled nanoparticles within cancer cells by confocal laser scanning microscopy. Fluorescence labeling by the conjugated polymers is also validated for quantitative determination of the internalized nanoparticles in each individual cell by flow cytometry analysis. Extensive overlap of blue and green fluorescence signals in the cytoplasm indicates that both conjugated polymer probes tightly bind to the surface of the nanoparticles during cellular internalization. The highly charged and fluorescence-labeled nanoparticles non-specifically bind to the cell membranes, followed by cellular uptake through endocytosis. The nanoparticles form aggregates inside endosomes, which yields a punctuated staining pattern. Cellular internalization of the nanoparticles is dependent on the dosage and time. Uptake efficiency can be enhanced three-fold by application of an external magnetic field. The nanoparticles are low cytotoxicity and suitable for simultaneously noninvasive fluorescence and magnetic resonance imaging application.
Dendritic cells and B cells maximize mucosal Th1 memory response to herpes simplex virus (2008)

Although the importance of cytotoxic T lymphocytes and neutralizing antibodies for antiviral defense is well known, the antiviral mechanism of Th1 remains unclear. We show that Th1 cells mediate noncytolytic antiviral protection independent of direct lysis through local secretion of IFN-gamma after herpes simplex virus (HSV) 2 infection. IFN-gamma acted on stromal cells, but not on hematopoietic cells, to prevent further viral replication and spread throughout the vaginal mucosa. Importantly, unlike other known Th1 defense mechanisms, this effector function did not require recognition of virally infected cells via MHC class II. Instead, recall Th1 response was elicited by MHC class II(+) antigen-presenting cells at the site of infection. Dendritic cells (DCs) were not required and only partially sufficient to induce a recall response from memory Th1 cells. Importantly, DCs and B cells together contributed to restimulating memory CD4 T cells to secrete IFN-gamma. In the absence of both DCs and B cells, immunized mice rapidly succumbed to HSV-2 infection and death. Thus, these results revealed a distinct mechanism by which memory Th1 cells mediate noncytolytic IFN-gamma-dependent antiviral protection after recognition of processed viral antigens by local DCs and B cells.
Regulatory Features Underlying Pollination-Dependent and -Independent Tomato Fruit Set Revealed by Transcript and Primary Metabolite Profiling (2009)

Abstract Indole Acetic Acid 9 (IAA9) is a negative auxin response regulator belonging to the Aux/IAA transcription factor gene family whose downregulation triggers fruit set before pollination, thus giving rise to parthenocarpy. In situ hybridization experiments revealed that a tissue-specific gradient of IAA9 expression is established during flower development, the release of which upon pollination triggers the initiation of fruit development. Comparative transcriptome and targeted metabolome analysis uncovered important features of the molecular events underlying pollination-induced and pollination-independent fruit set. Comprehensive transcriptomic profiling identified a high number of genes common to both types of fruit set, among which only a small subset are dependent on IAA9 regulation. The fine-tuning of Aux/IAA and ARF genes and the downregulation of TAG1 and TAGL6 MADS box genes are instrumental in triggering the fruit set program. Auxin and ethylene emerged as the most active signaling hormones involved in the flower-to-fruit transition. However, while these hormones affected only a small number of transcriptional events, dramatic shifts were observed at the metabolic and developmental levels. The activation of photosynthesis and sucrose metabolism-related genes is an integral regulatory component of fruit set process. The combined results allow a far greater comprehension of the regulatory and metabolic events controlling early fruit development both in the presence and absence of pollination/fertilization.
Cleanix (2016)

For big data, data quality problem is more serious. Big data cleaning system requires scalability and the abilityof handling mixed errors. Motivated by this, we develop Cleanix, a prototype system for cleaning relational Big Data. Cleanix takes data integrated from multiple data sources and cleans them on a shared-nothing machine cluster. The backend system is built on-top-of an extensible and flexible data-parallel substrate the Hyracks framework. Cleanix supports various data cleaning tasks such as abnormal value detection and correction, incomplete data filling, de-duplication, and conflict resolution. In this paper, we show the organization, data cleaning algorithms as well as the design of Cleanix.
Least-squares methods for identifying biochemical regulatory networks from noisy measurements (2007)

The significant improvements in performance demonstrated by the CTLS method under the wide range of conditions tested here, including different levels and types of measurement noise and different numbers of data points, suggests that its application will enable more accurate and reliable identification and modelling of biochemical networks.
Improved TCP performance over long-delay and error-prone links (2000)

The enormous growth in Internet use has led to a desire to provide efficient transfer over a variety of delivery technologies. However, using TCP as the transport layer can conflict with the physical characteristics of those links, severely limiting the efficiency of delivery. Work undertaken by Roke Manor Research Ltd has resulted in the development of enhancer technology that can dramatically improve throughput and efficiency. This paper describes the work undertaken and compares the results with standard TCP and TCP with satellite-friendly options. The problem of using TCP over long latency links is described and connection splitting is introduced as a solution to this problem. The various issues that are raised by the introduction of enhancers into the end-to-end path are then discussed. Results are introduced to show the benefits of protocol enhancement in realistic deployments and to measure absolute performance. Testing has showed that it is possible to split TCP connections with little or no damage to the underlying protocols and achieve significant increases in performance.
The relationship between the concha bullosa, nasal septal deviation and sinusitis. (2003)

In order to define the relation between the concha bullosa, nasal septal deviation and sinusitis, more detailed investigations are needed.
Heterodimers of Nanoparticles:  Formation at a Liquid−Liquid Interface and Particle-Specific Surface Modification by Functional Molecules (2004)

On the basis of a fundamental property of nanoparticles, the self-assembling at a liquid-liquid interface to form "colloidosomes", a heterogeneous reaction takes place on the exposed surface of the nanoparticles to produce the heterodimers of two distinct nanospheres, which can be modified by two different functional molecules in a particle-specific manner.
Is EPCR a multi-ligand receptor? Pros and cons (2012)

In the last decade, the endothelial cell protein C/activated protein C receptor (EPCR) has received considerable attention. The role initially attributed to EPCR, i.e. the enhancement of protein C (PC) activation by the thrombin-thrombomodulin complex on the surface of the large vessels, although important, did not go beyond the haemostasis scenario. However, the discovery of the cytoprotective, anti-inflammatory and anti-apoptotic features of the activated PC (APC) and the required involvement of EPCR for APC to exert such actions did place the receptor in a privileged position in the crosstalk between coagulation and inflammation. The last five years have shown that PC/APC are not the only molecules able to interact with EPCR. Factor VII/VIIa (FVII/VIIa) and factor Xa (FXa), two other serine proteases that play a central role in haemostasis and are also involved in signalling processes influencing wound healing, tissue remodelling, inflammation or metastasis, have been reported to bind to EPCR. These observations have paved the way for an exploration of unsuspected new roles for the receptor. This review aims to offer a new image of EPCR in the light of its extended panel of ligands. A brief update of what is known about the APC-evoked EPCR-dependent cell signalling mechanisms is provided, but special care has been taken to assemble all the information available about the interaction of EPCR with FVII/VIIa and FXa.
Microstructure, composition, and etching topography of dental ceramics. (2002)

The observations suggest that the etching mechanism is different for the three etchants, with HF producing the most prominent etching pattern on all dental ceramics examined.
Biotransformation of Eugenol to Ferulic Acid by a Recombinant Strain of <i>Ralstonia eutropha</i> H16 (2002)

The gene loci ehyAB, calA, and calB, encoding eugenol hydroxylase, coniferyl alcohol dehydrogenase, and coniferyl aldehyde dehydrogenase, respectively, which are involved in the first steps of eugenol catabolism in Pseudomonas sp. strain HR199, were amplified by PCR and combined to construct a catabolic gene cassette. This gene cassette was cloned in the newly designed broad-host-range vector pBBR1-JO2 (pBBR1-JO2ehyABcalAcalB) and transferred to Ralstonia eutropha H16. A recombinant strain of R. eutropha H16 harboring this plasmid expressed functionally active eugenol hydroxylase, coniferyl alcohol dehydrogenase, and coniferyl aldehyde dehydrogenase. Cells of R. eutropha H16(pBBR1-JO2ehyABcalAcalB) from the late-exponential growth phase were used as biocatalysts for the biotransformation of eugenol to ferulic acid. A maximum conversion rate of 2.9 mmol of eugenol per h per liter of culture was achieved with a yield of 93.8 mol% of ferulic acid from eugenol within 20 h, without further optimization.
Towards a biological and chemical definition of the hyporheic zone in two Canadian rivers (1989)

SUMMARY. 1. A series of samples of interstitial water and fauna was taken along transects from the channel into the bank in two small rivers in southern Ontario, Canada. These were examined for any discontinuities which might indicate the position of the hyporheic/groundwater interface. 2. There were several chemical discontinuities in Duffin Greek, with “break lines” occurring from about the river margin obliquely downwards under the bank for dissolved oxygen and carbon dioxide, B.O.D., alkalinity, suspended solids and amount of organic matter. Break lines in nitrate and sulphide concentration ran from near the margin obliquely down under the river bed. In the Rouge River, a discontinuity extending from a point approximately 1.5 m landwards from the margin obliquely down under the river was indicated by dissolved carbon dioxide, B.O.D., conductivity, suspended solids, organic matter, nitrate and alkalinity. 3. Ordination (DECORANA) and community classification (TWIN‐SPAN) revealed that, in both rivers, linear distance from mid‐river was the major factor associated with community structure. In both rivers the community under the bank was distinct from the river community and these two communities were separated by another community characteristic of the river margin. In Duffin Creek the classification procedure additionally discriminated surface and interstitial sub‐sets within the river community. 4. Most taxa showed no significant correlations with the chemistry of the interstitial water but. in Duffin Creek, the densities of the copepod Diacyclops crasscaudis brachycercus (Kiefer) and Oligochaeta were positively correlated with nitrate: worms were also negatively correlated with sulphide. In the Rouge River, density of hyporheic animals was negatively correlated with both conductivity and alkalinity of interstitial water; oligochactes were positively correlated with both nitrate and organic matter; and density of nematodes was positively correlated with sulphide concentration. 5. The hyporheic faunas of these two rivers were dominated by insects, particularly chironomids. Compared with the hyporheos of rivers in Europe and Colorado, the two Ontario rivers lack significant numbers of harpacticoid copepods as well as bathynellacid, amphipod and isopod crustaceans.