gebhart/patrepeval huggingface dataset:
Soybean Protein Dispersions as Printing Ink Vehicles (1943)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSoybean Protein Dispersions as Printing Ink VehiclesAlfred F. Schmutzler and Donald F. OthmerCite this: Ind. Eng. Chem. 1943, 35, 11, 1196–1202Publication Date (Print):November 1, 1943Publication History Published online1 May 2002Published inissue 1 November 1943https://pubs.acs.org/doi/10.1021/ie50407a014https://doi.org/10.1021/ie50407a014research-articleACS PublicationsRequest reuse permissionsArticle Views51Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Regulation of NF-kB in multiple myeloma: therapeutic implications. (2004)

The nuclear factor kappa B (NF-kappaB) family of transcription factors plays a major role in inflammation, immune and stress responses, oncogenesis, cell migration, and angiogenesis. Aberrant activation of NF-kappaB has also been shown to contribute to intrinsic and inducible drug resistance in numerous cancers, including multiple myeloma. The expression of NF-kappaB-responsive targets will vary depending on the cellular context and type of inducer. The regulation of NF-kappaB activity occurs at multiple levels involving the IkappaB kinase (IKK) complex, members of the IkappaB family, recruitment of heterologous transcription factors and coactivators by NF-kappaB, and post-translational modifications of p65. This article highlights regulatory mechanisms responsible for constitutive NF-kappaB activation and provides justification for target-based therapy for NF-kappaB in multiple myeloma.
3DeFDR: statistical methods for identifying cell type-specific looping interactions in 5C and Hi-C data (2020)

An important unanswered question in chromatin biology is the extent to which long-range looping interactions change across developmental models, genetic perturbations, drug treatments, and disease states. Computational tools for rigorous assessment of cell type-specific loops across multiple biological conditions are needed. We present 3DeFDR, a simple and effective statistical tool for classifying dynamic loops across biological conditions from Chromosome-Conformation-Capture-Carbon-Copy (5C) and Hi-C data. Our work provides a statistical framework and open-source coding libraries for sensitive detection of cell type-specific loops in high-resolution 5C and Hi-C data from multiple cellular conditions.
Localization of multiple simultaneous sound sources in reverberant conditions using blind source separation methods (2011)

In this paper, we address the problem of multiple simultaneous sources localization by means of Blind Source Separation (BSS)-based algorithms. Considering BSS demixing filters as some blind null beamformer and producing an acoustical map from them, source localization can then be achieved by identifying the local minima of this acoustical map. To improve the performance of this method in reverberant environments, we have proposed to replace the demixing filter with one corresponds to only the direct path. This is done by keeping only the largest coefficient in each demixing filter and neglecting the other coefficients. Furthermore, the proposed method reduces the computational complexity. Our experiments demonstrate the efficiency of the proposed method in the localization of multiple simultaneous sound sources in reverberant environments.
Mercury BLASTN: Faster DNA Sequence Comparison using a Streaming Hardware Architecture (2007)

Large-scale DNA sequence comparison, as implemented by BLAST and related algorithms, is one of the pillars of modern genomic analysis. One way to accelerate these computations is with a streaming architecture, in which processors are arranged in a pipeline that replicates the multistage structure of the algorithm. To achieve high performance, the processor hardware implementing the critical seed matching and ungapped extension stages of BLAST should be specialized to execute these stages as quickly as possible. However, accelerating these stages requires solving two key problems: first, the seed matching stage is not of a form which has traditionally been amenable to hardware acceleration; and second, the accelerated implementation of BLAST should retain sensitivity at least comparable to that of the original software. We describe Mercury BLASTN, an FPGA-based implementation of BLAST for DNA. Mercury BLASTN combines a Bloom filtering approach to seed matching with a modified ungapped extension algorithm. On a previous generation FPGA hardware platform, Mercury BLASTN runs 5 to 11 times faster than NCBI BLASTN current-generation general-purpose CPUs, with the prospect of a further eightfold speedup on current-generation FPGAs. Moreover, its sensitivity to significant DNA sequence alignments is 99% of that observed with software NCBI BLASTN. 1.
Graph matching applications in pattern recognition and image processing (2004)

In this paper we will try to characterize the role that graphs are conquering within the pattern recognition field. To this aim, a taxonomy built considering the most common applications of graph based techniques in the pattern recognition and image processing field is presented and discussed.
Imaging of oxidative stress at subcellular level by confocal laser scanning microscopy after fluorescent derivatization of cellular carbonyls. (1993)

Confocal laser scanning fluorescence microscopy plus image videoanalysis was used to visualize the tissue areas and the subcellular sites first involved by oxidative stress and lipid peroxidation, in the well-established experimental model of lipid peroxidation induced by haloalkane intoxication in the liver cell. The fluorescent reagent 3-hydroxy-2-naphthoic acid hydrazide was employed to derivativize the carbonyl functions originating from the lipoperoxidative process in situ, in liver cryostat sections from in vivo intoxicated rats, as well as in isolated hepatocytes exposed in vitro to the pro-oxidant action of haloalkanes. The results obtained indicate that: 1) the detection of fluorescent derivatives of carbonyls indeed offers a gain in sensitivity, 2) haloalkane-induced lipid peroxidation in hepatocytes primarily involves the perinuclear endoplasmic reticulum, whereas the plasma membrane and the nuclear compartment are unaffected, and 3) lipid peroxidation also induces an increase of liver autofluorescence.
Human umbilical cord blood‐derived mesenchymal stem cells improve functional recovery through thrombospondin1, pantraxin3, and vascular endothelial growth factor in the ischemic rat brain (2015)

Cell therapy is a potential therapeutic method for cerebral ischemia, which remains a serious problem. In the search for more effective therapeutic methods, many kinds of stem cells from various tissues have been developed and tested as candidate therapeutic agents. Among them, human umbilical cord blood (hUCB)-derived mesenchymal stem cells (MSCs) are widely used for cell therapy because of their genetic flexibility. To confirm that they are effective and understand how they affect ischemic neural cells, hUCB-MSCs were directly administered ipsilaterally into an ischemic zone induced by middle cerebral artery occlusion (MCAO). We found that the neurobehavioral performance of the hUCB-MSC group was significantly improved compared with that of the vehicle-injected control group. The infarct was also remarkably smaller in the hUCB-MSC group. Additionally, hUCB-MSC transplantation resulted in a greater number of newly generated cells and angiogenic and tissue repair factors and a lower number of inflammatory events in the penumbra zone. To determine why these events occurred, hUCB-MSCs were assayed under hypoxic and normoxic conditions in vitro. The results showed that hUCB-MSCs exhibit higher expression levels of thrombospondin1, pantraxin3, and vascular endothelial growth factor under hypoxic conditions than under normoxic conditions. These results were found to be correlated with our in vivo immunofluorescent staining results. On the basis of these findings, we suggest that hUCB-MSCs may have a beneficial effect on cerebral ischemia, especially through angiogenesis, neurogenesis, and anti-inflammatory effects, and thus could be used as a therapeutic agent to treat neurological disorders such as cerebral ischemia.
Development of a novel recombinant biotherapeutic with applications in targeted therapy of human arthritis (2011)

Here we report for the first time the identification of an scFv antibody, A7, that specifically recognizes an epitope expressed in the microvasculature of human arthritic synovium and that has the potential to be developed as a joint-specific pharmaceutical.
Advances in use of functionalized carbon nanotubes for drug design and discovery (2012)

Carbon nanotubes combine more properties relevant to drug development and delivery than any other nanomaterial. Although a tremendous amount of basic research has been done on CNTs during the past decade, little of this is nearing translation into human applications. No CNT-based medicine has reached clinical trials. Nevertheless, CNT conjugation with other molecules has extended the horizons for their potential therapeutic applications. The most promising of these is PEGylation, which extends the survival of CNTs in circulation. Potential future applications of CNTs include combination of diagnostics and therapeutic drug delivery as well as a component of multimodal therapies for tissue regeneration.
Integration and Testing of a Wide-Band Airport Pseudolite (2000)

The Federal Aviation Administration (FAA) baseline
architecture for the Local Area Augmentation System
(LAAS) includes Airport Pseudolites (APLs) as the
preferred method for augmenting Differential Global
Positioning System (DGPS) to achieve the availability
required to support Category II/III operations.
The FAA utilized a Cooperative Agreement with the Air
Transport Association (ATA) to procure and test a
prototype APL system. The specification for procurement of the APL system was the most current design
specification developed by RTCA working group 4A.
Key parameters in the APL signal in space format were
implemented to be variable in the prototype unit to allow
refinement of the standards.
This paper first describes APL interference testing
performed for the FAA by the ARINC SITE Laboratory.
Tests were conducted on a selection of military and
commercial GPS receivers. These interference tests
explored the effects of the specified APL signal on the
performance of standard GPS receivers. Additional tests
were done while the APL parameters were varied over a
wider range to allow flexibility during field tests. The
interference tests concluded that the APL had minimal or
no effect on the ability of GPS receivers to acquire and
track the GPS satellite signal.
Upon completion of the interference testing, the APL
system was integrated into the LAAS Test Prototype
(LTP). The FAA William J. Hughes Technical Center
(WJHTC) is the primary test location for FAA LAAS
testing and home to the LTP. This paper describes the
integration of the APL system into the LTP.
The paper provides initial results of a series of flight tests
conducted using the LTP/APL system. United Parcel
Service (UPS) provided a Boeing 767 to be used as a test
vehicle that would represent a typical LAAS platform. A
total of 39 precision approaches were conducted at the
Atlantic City International Airport (ACY) using the LTP
for guidance.
Initial results have shown that the specified APL signal
format required some modification before the APL could
provide sufficient average power to allow the tested GPS
receivers to acquire and track the signal in space. The
APL signal was received by the top mounted antenna of
the Boeing 767, but the expected coverage range was
about half of what was expected. The body of the aircraft
did at times prevent APL signal acquisition by blocking
and attenuating the APL signal.
A novel rate control method for H.264 video coding (2005)

This paper proposes a H.264 rate control method considering picture characteristics and buffer constraints. Selecting the optimum buffer size corresponding to each application's requirement gives better compression quality and functionality. However, conventional methods allocate the number of bits equally to each GOP and do not explicitly consider the buffer size, where picture quality might not be optimal and the buffer size is not optimally determined for applications. This paper provides a bit allocation method that reflects the picture characteristic of each frame while keeping the buffer transition compliant within a given size. In the proposed method, the number of bits to be generated is estimated from the complexity of each frame, and it is adjusted by a scaling coefficient newly introduced in this paper. Thus, the allocated number of bits reflects picture characteristics and fully complies with buffer constraints. Experimental results show that the proposed method improves picture quality and suppresses quality fluctuation.
Omitted Letters in Crosswords (2006)

Sixty or more years ago I read a humorous story - possibly by A.A. Milne - in which the two main characters were called ETAION and SHRDLU. Later I came to realise that these names were taken from a letter frequency list There are a number of these lists with small differences between them reflecting the context of the letter count. For Language on Vacation Dmitri Borgmann used one starting ETAISONHRDLU, differing from my author's only in the positioning of the S. This article is concerned with letters in crosswords, but it starts from the other end by looking at letters not present in their solutions.
Power line carrier emissions from transmission lines (1992)

Extensive ground-based and air-based measurements of the three-dimensional power line carrier (PLC) field radiating from various transmission limes and transformer stations were performed. The measurements were conducted in two frequency ranges: below 200 kHz and above 470 kHz. Results of preliminary tests on the susceptibility of one automatic direction finding receiver are also presented. Comparisons are made of the measurements with those made by others. An algorithm is presented to assist in converting ground-based measurements into a predicted field at any point around a PLC line.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Three classes of glucocerebrosidase inhibitors identified by quantitative high-throughput screening are chaperone leads for Gaucher disease (2007)

Gaucher disease is an autosomal recessive lysosomal storage disorder caused by mutations in the glucocerebrosidase gene. Missense mutations result in reduced enzyme activity that may be due to misfolding, raising the possibility of small-molecule chaperone correction of the defect. Screening large compound libraries by quantitative high-throughput screening (qHTS) provides comprehensive information on the potency, efficacy, and structure-activity relationships (SAR) of active compounds directly from the primary screen, facilitating identification of leads for medicinal chemistry optimization. We used qHTS to rapidly identify three structural series of potent, selective, nonsugar glucocerebrosidase inhibitors. The three structural classes had excellent potencies and efficacies and, importantly, high selectivity against closely related hydrolases. Preliminary SAR data were used to select compounds with high activity in both enzyme and cell-based assays. Compounds from two of these structural series increased N370S mutant glucocerebrosidase activity by 40-90% in patient cell lines and enhanced lysosomal colocalization, indicating chaperone activity. These small molecules have potential as leads for chaperone therapy for Gaucher disease, and this paradigm promises to accelerate the development of leads for other rare genetic disorders.
Neuro-Oncology Update: Radiation Safety and Nursing Care During Interstitial Brachytherapy (1987)

Radiation control and safety are major considerations for nursing personnel during the care of patients receiving brachytherapy. Since the theory and practice of radiation applications are not part of the routine curriculum of nursing programs, the education of nurses and other health care professionals in radiation safety procedures is important. Regulatory agencies recommend that an annual safety course be given to all persons frequenting, using, or associated with patients containing radioactive materials. This article presents pertinent aspects of the principles and procedures of radiation safety, the role of personnel dose-monitoring devices, and the value of additional radiation control features, such as a lead cubicle, during interstitial brain implants. One institution's protocol and procedures for the care of high-intensity iridium-192 brain implants are discussed. Preoperative teaching guidelines and nursing interventions included in the protocol focus on radiation control principles.
Tibialis posterior in health and disease: a review of structure and function with specific reference to electromyographic studies (2009)

Tibialis posterior has a vital role during gait as the primary dynamic stabiliser of the medial longitudinal arch; however, the muscle and tendon are prone to dysfunction with several conditions. We present an overview of tibialis posterior muscle and tendon anatomy with images from cadaveric work on fresh frozen limbs and a review of current evidence that define normal and abnormal tibialis posterior muscle activation during gait. A video is available that demonstrates ultrasound guided intra-muscular insertion techniques for tibialis posterior electromyography.Current electromyography literature indicates tibialis posterior intensity and timing during walking is variable in healthy adults and has a disease-specific activation profile among different pathologies. Flat-arched foot posture and tibialis posterior tendon dysfunction are associated with greater tibialis posterior muscle activity during stance phase, compared to normal or healthy participants, respectively. Cerebral palsy is associated with four potentially abnormal profiles during the entire gait cycle; however it is unclear how these profiles are defined as these studies lack control groups that characterise electromyographic activity from developmentally normal children. Intervention studies show antipronation taping to significantly decrease tibialis posterior muscle activation during walking compared to barefoot, although this research is based on only four participants. However, other interventions such as foot orthoses and footwear do not appear to systematically effect muscle activation during walking or running, respectively. This review highlights deficits in current evidence and provides suggestions for the future research agenda.
Variable Phase Dark-Field Contrast—A Variant Illumination Technique for Improved Visualizations of Transparent Specimens (2012)

Variable phase dark-field contrast has been developed as an illumination technique in light microscopy, which promises significant improvements and a higher variability in imaging of several transparent specimens. In this method, a phase contrast image is optically superimposed on a dark-field image so that a partial image based on the principal zeroth-order maximum (phase contrast) interferes with an image that is based on the secondary maxima (dark field). The background brightness and character of the resulting image can be continuously modulated from a phase-contrast-dominated to a dark-field-dominated character. The condenser aperture diaphragm can be used for modulations of the image's appearance. Specimens can either be illuminated concentrically or obliquely (eccentrically) when parts of the illuminating light beams are covered and blocked. Moreover, a bright-field-like partial image can be added. In this way, the illumination can be optimally adjusted to the specific properties of the specimen. The techniques described can lead to improved visual information especially in biological specimens consisting of phase structures and additional light-absorbing or -reflecting components. Moreover, the specimen's three-dimensionality can be accentuated with improved clarity because the illuminating light beams associated with phase contrast and dark field run to the specimen at different angles of incidence.
Caracterização de quitosanas comerciais de diferentes origens (2003)

A quitosana é um polissacarídeo linear obtido da desacetilação da quitina. As propriedades físico-químicas da quitosana são função do grau médio de acetilacão <img border=0 id="_x0000_i1026" src="../../../../img/revistas/po/v13n4/19880x1.gif" align=absmiddle>e da massa molar média (<img border=0 id="_x0000_i1027" src="../../../../img/revistas/po/v13n4/19880x2.gif" align=absmiddle>). Várias aplicações da quitosana foram propostas na literatura, principalmente no tratamento de águas, produção de cosméticos, drogas e medicamentos, aditivos alimentícios, membranas semipermeáveis e no desenvolvimento de biomateriais. Neste trabalho, três diferentes tipos de quitosanas comerciais foram caracterizados por ressonância magnética nuclear de hidrogênio (RMN ¹H), espectroscopia de absorção na região do infravermelho (IV), titulação condutimétrica e análise térmica (TG e DSC) com o objetivo de comparar as características de quitosanas provenientes de diferentes fornecedores. A massa molar média das amostras foi determinada a partir de medidas de viscosidade intrínseca. Os resultados obtidos por estas técnicas mostraram diferenças quanto ao grau médio de acetilação (ou desacetilação), em função da procedência do material. Os resultados obtidos da análise térmica permitiram acompanhar os processos de desidratação, decomposição e a temperatura de transição vítrea (Tg).
Simple 3D Reconstruction of Single Indoor Image with Perspective Cues (2009)

Image-based modeling is a longstanding research topic in computer vision. Reconstruction based on a single image is a particularly difficult example. This paper presents a simple reconstruction method that quickly extracts 3D geometric structure from a single indoor photograph consisting mainly of orthogonal planes. Our method takes advantage of perspective cues and uses basic knowledge of photography and achieves a fully automated reconstruction of the scene.