gebhart/patrepeval huggingface dataset:
Factor Analysis of the Mystical Experience Questionnaire: A Study of Experiences Occasioned by the Hallucinogen Psilocybin (2012)

A large body of historical evidence describes the use of hallucinogenic compounds, such as psilocybin mushrooms, for religious purposes. But few scientific studies have attempted to measure or characterize hallucinogen-occasioned spiritual experiences. The present study examined the factor structure of the Mystical Experience Questionnaire (MEQ), a self-report measure that has been used to assess the effects of hallucinogens in laboratory studies. Participants (N=1602) completed the 43-item MEQ in reference to a mystical or profound experience they had had after ingesting psilocybin. Exploratory factor analysis of the MEQ retained 30 items and revealed a 4-factor structure covering the dimensions of classic mystical experience: unity, noetic quality, sacredness (F1); positive mood (F2); transcendence of time/space (F3); and ineffability (F4). MEQ factor scores showed good internal reliability and correlated with the Hood Mysticism Scale, indicating convergent validity. Participants who endorsed having had a mystical experience on psilocybin, compared to those who did not, had significantly higher factor scores, indicating construct validity. The 4-factor structure was confirmed in a second sample (N=440) and demonstrated superior fit compared to alternative models. The results provide initial evidence of the validity, reliability, and factor structure of a 30-item scale for measuring single, hallucinogen-occasioned mystical experiences, which may be a useful tool in the scientific study of mysticism.
Representation of IP Routing Policies in a Routing Registry (ripe-81++) (1995)

This document was originally published as a RIPE document known as ripe-181 but is also being published as an Informational RFC to reach a larger audience than its original scope. It has received community wide interest and acknowledgment throughout the Internet service provider community and will be used as the basic starting point for future work on Internet Routing Registries and routing policy representation. It can also be referred to as ripe-81++. This document is an update to the original 'ripe-81'[1] proposal for representing and storing routing polices within the RIPE database. It incorporates several extensions proposed by Merit Inc.[2] and gives details of a generalized IP routing policy representation to be used by all Internet routing registries. It acts as both tutorial and provides details of database objects and attributes that use and make up a routing registry.
Sodium Iodate Selectively Injuries the Posterior Pole of the Retina in a Dose-Dependent Manner: Morphological and Electrophysiological Study (2010)

Sequential morphological and functional features of retinal damage in mice exposed to different doses (40 vs. 20 mg/kg) of sodium iodate (NaIO(3)) were analyzed. Retinal morphology, apoptosis (TUNEL assay), and function (electroretinography; ERG) were examined at several time points after NaIO(3) administration. The higher dose of NaIO(3) caused progressive degeneration of the whole retinal area and total suppression of scotopic and photopic ERG. In contrast, the lower dose induced much less severe degeneration in peripheral part of retina along with a moderate decline of b- and a-wave amplitudes in ERG, corroborating the presence of regions within retina that retain their function. The peak of photoreceptor apoptosis was found on the 3rd day, but the lower dose induced more intense reaction within the central retina than in its peripheral region. In conclusion, these results indicate that peripheral area of the retina reveals better resistance to NaIO(3) injury than its central part.
A Homobifunctional Rhodamine for Labeling Proteins with Defined Orientations of a Fluorophore (1998)

The synthesis and characterization of a bifunctional rhodamine dye bearing 2-(iodoacetamido)ethyl substituents on the 3'- and 6'-nitrogen atoms is described. Aspects of the conversion of chloroacetamides to iodoacetamides are discussed, including a remarkably mild dehalogenation of an aromatic haloacetamide in the presence of NaI and camphorsulfonic acid. The bifunctional rhodamine has been designed for two-site, 1:1 labeling of proteins that contain two suitably disposed cysteine residues and is intended to constrain the orientation of the rhodamine absorption and emission dipoles in a predictable relationship to the protein structure.
Abstract 3211: FGFR1 and FGFR2 gene copy number variations in prostate cancer (2011)

Abstract Patients with hormone refractory prostate cancer (HRPC) have very few clinical options. A bottle neck in development of new therapies is the poor understanding of the molecular basis of hormone independency. A pathway thought to be important in this progression is FGFR. Amplification of FGFR1 has been observed in breast cancer and has led to the hypothesis that it is involved in Tamoxifen resistance (Turner et al., 2010). Here we evaluated the copy number variations (CNV) of the gene loci of FGFR1 (8p12) and FGFR2 (10q26) by dual color FISH in FFPE tissue of recurrent PC patients (n=28), non-recurrent PC patients (n=15), PC patients undergoing palliative RPE (n=15), patients with benign prostate hyperplasia (n=17) and tumor free tissue samples (n=12). We analyzed CNV between different clinical patient subgroups. Two types of CNV for the gene loci of FGFR1 and FGFR2 were observed. Either the gene dose of the target gene locus occurred to be amplified or the gene dose was elevated due to polysomy of the respective chromosome. Furthermore patients with CNV of FGFR1 or FGFR2 exhibited in 40-50% intra tumor heterogeneity by presenting normal cells and cells with CNV. FGFR1 gene dose elevations (either due to gene locus amplification or polysomy of chromosome 8) were observed in 7% (1/15) of patients without recurrence but in 49% (17/35) of the patients with recurrence. Also, in patients undergoing palliative RPE 75% (12/16) of the patients exhibited FGFR1 gene dose elevation. In the case of FGFR2, gene dose elevations (gene locus amplification or polysomy of chromosome 10) were observed in none of the patients without recurrence but in 13% of the patients with recurrence and in 20% of patients undergoing palliative RPE. In the control groups such variations were not found. Interestingly, the gene dose variations differed in the prostate cancer patients depending on their hormone sensitivity. 47% (7/15) of hormone refractory patients and 30% (6/20) of the hormone sensitive patients showed elevated FGFR1 gene dose, for FGFR2, 30% and 20% of the respective subgroups were affected. In summary we conclude that this is first evidence that CNV of FGFR1 and FGFR2 might have implications for hormone resistance in PC. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3211. doi:10.1158/1538-7445.AM2011-3211
Enhanced Military Decision Modeling Using a MultiAgent System Approach (2003)

The U.S. military uses modeling and simulation as a tool to help meet its warfighting needs. A key element within military simulations is the ability to accurately represent human behavior. This is especially true in a simulation&apos;s ability to emulate realistic military decisions. However, current decision models fail to provide the variability and flexibility that human decision makers exhibit. Further, most decision models are focused on tactical decisions and ignore the decision process of senior military commanders at the operational level of warfare. In an effort to develop a better decision model that would mimic the decision process of a senior military commander, this research sought to identify an underlying cognitive process and computational techniques that could adequately implement it. Recognition-Primed Decision Making (RPD) was identified as one such model that characterized this process. Multiagent system simulation was identified as a computational system that could mimic the cognitive process identified by RPD. The result was a model of RPD called RPDAgent. Using an operational military decision scenario to test model validity, decisions produced by RPDAgent were compared against decisions made by military officers. It was found that RPDAgent produced decisions that were equivalent to its human counterparts. RPDAgent&apos;s decisions were not optimum decisions, but decisions that reflected the variability inherent in those made by humans in an operational military environment.
Alpha-methyl ornithine, a potent competitive inhibitor of ornithine decarboxylase, blocks proliferation of rat hepatoma cells in culture. (1976)

A biphasic increase of putrescine concentration occurs in rat hepatoma tissue culture cells induced to proliferate. DL-alpha-Methyl ornithine, a competitive inhibitor of ornithine decarboxylase ( L-ornithine carboxylyase, EC 4.1.1.7) of hepatoma tissue culture cells, blocks the usual increases of putrescine and spermidine concentrations in these cells, and causes a rapid fall in the levels of putrescine which is followed by a striking decrease of spermidine. In parallel with the depletion of these amines, incorporation of [3H]thymidine into DNA and cell proliferation are inhibited. Addition of putrescine, spermidine, or spermine results in an immediate resumption of cell proliferation. Cell proliferation is also restored by L-ornithine presumably due to in situ competitive inhibition of ornithine decarboxylase. These findings of hepatoma tissue culture cells support the concept that polyamines play an essential function in the cell division processes.
Highly Efficient Catalytic Aerobic Oxidations of Benzylic Alcohols in Water (2004)

A highly efficient catalytic system without transition metals in water has been developed for aerobic oxidations of benzylic alcohols. The newly developed catalyst system could oxidize benzylic alcohols and heteroaromatic analogues with 1 mol % TEMPO as a catalyst and with a catalytic amount of 1,3-dibromo-5,5-dimethylhydantoin and NaNO2 as cocatalysts. Under the optimal conditions, various alcohols could be converted into their corresponding aldehydes or ketones in high yields.
The RF system of a typical clinical linear accelerator (2002)

The author describes the RF system of a typical clinical linear accelerator used for radiotherapy purposes. Having worked on the Varian Clinac 2100 (CL2100) series and its predecessors for several years, he chooses it as typical. It is a very complex electromechanical device weighing over 10 tons and capable of being serviced by a moderately trained technician. The CL2100 is a klystron driven machine, but there are few differences between these and magnetron driven systems (CL600) series.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A novel analysis of Optimal Power Flow with TCPS (2015)

Optimal power flow (OPF) is one of the most important algorithms available to utility for generating least cost generation patterns in a power system satisfying transmission and operational constraints. A wide variety of conventional techniques are available to obtain solution. In day to day life, the forecasted loads used in classical OPF algorithms are increasing with time and are also not completely free from errors. By varying the load demands leads to overloading of the transmission lines and forecasted errors cause loss of optimal system. So in this modern optimal power flow algorithms may not be able to provide optimal solutions. This paper presents solution of optimal power flow problem for 30bus system via a simple genetic algorithm analysis. Our objective is to minimize the fuel cost and keep the power outputs of Alternators, Line bus voltages, line shunt capacitors/reactors and transformers tap-setting in their secure limits.
Endosteal implants and iliac crest grafts to restore severely resorbed totally edentulous maxillae--a retrospective study. (1994)

Autogenous grafts in conjunction with endosteal implants may be indicated in conditions of severe atrophy of the maxilla. From July, 1984, to December, 1990, 20 severely atrophic arches were restored with iliac crest onlay block grafts, subantral augmentation, and 148 endosteal root-form implants. Twenty-one implants were placed at the same time as the graft to stabilize a corticotrabecular bone block. Two implants were lost (90% implant survival). One hundred twenty-seven implants were placed after graft maturity, and one implant was removed (99% implant survival). Thirteen fixed restorations and 7 completely implant-supported overdentures were fabricated. Follow-up evaluation of prostheses and implants ranged from 26 to 97 months. All the implants used for initial prosthesis fabrication and all initial prostheses remain in function. The advantages of implant placement after graft maturity and subantral augmentation are addressed. One year after implant placement, the amount of additional bone lost around the implants placed in grafted bone is similar to the bone loss around maxillary implants inserted into non-grafted bone.
THE ROLE OF LEUCYL-LEUCINE METHYL ESTER-SENSITIVE CYTOTOXIC CELLS IN SKIN ALLOGRAFT REJECTION (1992)

Treatment of murine spleen cells (SpC) with L-leucyl-L-leucine methyl ester (Leu-Leu-OMe) depletes L3T4(+) and Lyt2(+) cytotoxic T lymphocyte precursors and the capacity to generate lethal graft-versus-host disease in semiallogeneic class I + II MHC and multiple non-MHC-disparate recipient mice, whereas T helper cell function is preserved. In the present studies the role of Leu-Leu-OMe-sensitive CTL in skin graft rejection was examined. C57BL/6J (B6) mice were serially thymectomized, lethally irradiated, reconstituted with T cell-depleted bone marrow, and treated with intraperitoneal injections of anti-L3T4 and anti-Lyt2 monoclonal antibodies. These adult thymectomized, bone marrow-reconstituted, T cell-depleted (ATXBM, TCD) mice were unable to reject B6xDBA/2F1 (B6D2F1) skin grafts. When such ATXBM, TCD mice were reconstituted with 7 x 10(7) control B6 SpC, acute rejection of B6D2F1 skin was observed. When B6 donor SpC were Leu-Leu-OMe-treated prior to transfer to ATXBM, TCD mice, uniform rejection of B6D2F1 skin grafts was still observed, although a significant delay in the time to rejection was observed. More rigorous T cell depletion of ATXBM, TCD host mice by infusion of antithymocyte globulin did not prevent delayed rejection of B6D2F1 skin initiated by transfer of Leu-Leu-OMe-treated B6 SpC. Despite the lack of complete prevention of skin allograft rejection, Leu-Leu-OMe treatment of B6 donor cells prevented lethal GVHD even in thymectomized B6D2F1 recipients. Precursors of anti-B6D2F1-specific CTL were greatly reduced or undetectable in unreconstituted ATXBM, TCD mice or in irradiated B6D2F1 recipients of Leu-Leu-OMe-treated B6 SpC. By contrast, ATXBM, TCD recipients of Leu-Leu-OMe-treated B6 SpC were found to contain a population of anti-class I MHC-specific CTL precursors of host origin within 28 days of reconstitution. These findings have indicated a number of features of the cells involved in skin graft rejection. First, Leu-Leu-OMe-sensitive CTL play a major role in acute rejection of class I + II MHC and multiple non-MHC antigen-disparate skin grafts. Moreover, the thymus-independent expansion of host-derived CTL precursors in ATXBM, TCD mice reconstituted with syngeneic Leu-Leu-OMe-resistant T helper cells also appears to play a role in mediating rejection of allogeneic skin grafts.
Arachidonoyl transacylase in human platelets. Coenzyme A-independent transfer of arachidonate from phosphatidylcholine to lysoplasmenylethanolamine. (1983)

Human platelets contain an enzyme that catalyzes CoA-independent release of arachidonic acid from phosphatidylcholine with concomitant incorporation into plasmenylethanolamine. Addition of lysoplasmenylethanolamine (10-80 microM) to a crude membrane preparation of prelabeled platelets (0.24 mg of protein/ml) induces transfer of [3H]arachidonate from endogenous phosphatidylcholine to lysoplasmenylethanolamine (0.8 nmol of arachidonic acid/min/mg of protein). The transacylation reaction occurs in the absence of Ca2+, has a broad pH optimum from 7 to 8, is not affected by excess unlabeled arachidonic acid, and is inhibited by N-ethylmaleimide (0.2 mM) and Triton X-100 (0.1 mg/ml). The enzyme shows a high specificity toward the acyl donor (phosphatidylcholine), transfers fatty acids in the order: arachidonic greater than eicosatrienoic greater than oleic, and preferentially acylates lysoplasmenylethanolamine but also other lysophosphatides (lysophosphatidylethanolamine greater than lysophosphatidylserine greater than lysophosphatidylinositol = 0). Platelet acyltransferase, on the other hand, acylates ethanolamine lysophosphatides with free arachidonic acid in the order: lysophosphatidyl-ethanolamine greater than lysoplasmenylethanolamine. These results suggest that a distinct acylation mechanism exists for introduction of arachidonic acid into plasmalogen phosphatides. In stimulated platelets, the transacylase may play an additional role in the controlled release of esterified arachidonic acid for synthesis of the biologically active oxygenated metabolites.
Identification of human erythrocyte blood group antigens on decay- accelerating factor (DAF) and an erythrocyte phenotype negative for daf (1988)

Decay accelerating factor (DAF) is a glycoprotein present on the surfaces of many types ofcells in contact with plasma, including erythrocytes, leukocytes, and platelets (reviewed in reference 1). A small amount of DAF is also present in serum. Numerous investigators have demonstrated that DAF inhibits the action of C3 convertases on cell surfaces, and its absence has been shown to be at least partially responsible for the abnormal sensitivity to lysis by complement exhibited by erythrocytes of patients with the acquired stem cell disorder paroxysmal nocturnal hemoglobinuria (PNH) (2). Hereditary absence of DAF has not been previously described. Tc(a) and Cr(a) are high-frequency human erythrocyte antigens . These antigens are part of a family of blood group antigens, designated Cromer related, which are all absent from the null phenotype cell IFC(-) , or Inab (3). Recently, Spring and colleagues (4) have identified two monoclonal antibodies which bound to high frequency red cell antigens absent from the Inab phenotype. They also demonstrated that these antibodies, as well as several human antisera to Cromer-related antigens, bound to a 70-kD glycoprotein when used to stain immunoblots of human erythrocyte membrane proteins . Because the wide tissue distribution of mAb reactivity, along with some of the biochemical characterization and immunoblotting data, was similar to that of DAF, we investigated whether the Cromer-related antigens Cr(a) and Tc(a) resided on the DAF molecule.
Automatic linking of thesauri (1996)

Article Automatic linking of thesauri Share on Authors: S. Amba Information Area, Central Leather Research Institute, Adyar, Madras 600 020 Information Area, Central Leather Research Institute, Adyar, Madras 600 020View Profile , N. Narasimhamurthi Dept. of Electrical and Computer Engineering, University of Michigan-Dearborn, Dearborn, Michigan Dept. of Electrical and Computer Engineering, University of Michigan-Dearborn, Dearborn, MichiganView Profile , Kevin C. O'Kane Dept. of Computer Science, University of Northern Iowa, Iowa Dept. of Computer Science, University of Northern Iowa, IowaView Profile , Philip M. Turner School of Library and Information Studies, University of Alabama, AL School of Library and Information Studies, University of Alabama, ALView Profile Authors Info & Claims SIGIR '96: Proceedings of the 19th annual international ACM SIGIR conference on Research and development in information retrievalAugust 1996 Pages 181–186https://doi.org/10.1145/243199.243265Published:18 August 1996 8citation347DownloadsMetricsTotal Citations8Total Downloads347Last 12 Months1Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Power supply noise aware workload assignment for multi-core systems (2008)

As the industry moves from single- to multicore processors, the challenges of how to reliably design and analyze power delivery for such systems also arise. We study various workload assignments to cores and their impact on the global power grid noise. We develop metrics to estimate the amount of noise propagated from core to core and propose a power supply noise aware workload assignment method. In our experiments, we show that performance loss can be significant if workload assignment is not properly made.
A direct conversion receiver utilizing a novel FSK demodulator and a low-power-consumption quadrature mixer (2003)

Two novel technologies of direct conversion are introduced. One is an FSK demodulator based on a new architecture, and the other is a quadrature mixer for direct conversion. The FSK demodulator is composed of relative 90 degrees phase shifters and frequency multipliers suitable for digital circuit implementation, and it has shown a wide allowance for offsets of the local frequency. In designing the quadrature mixer IC, structural and numerical optimization was carried out for low power consumption. The demodulator and the quadrature mixer, including the surrounding circuits, have been integrated. In order to realize smaller size and advanced performance, the authors adopt appropriate silicon processes for each of these two ICs. The FSK direct conversion radio data receiver with a bit rate of 1200 b/s developed utilizing the above ICs has achieved excellent performance, as expected.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Wireless barcodes for tagging infrastructure (2014)

There are numerous scenarios where embedding static information into objects would prove to be very useful. For example, by embedding navigation information into the road surface we could enable driverless cars, similarly embedding information into major infrastructure such as building walls would enable easier classification of debris, and so forth. The key requirement is that the embedded information should survive as long as the infrastructure itself. We discuss the concept of wireless barcodes that allow us to achieve exactly this goal of tagging infrastructure. The barcodes are designed to be read at terahertz frequencies that allows good packing of information (bits/m). We use a TDoA (Time Difference of Arrival) technique to read the barcodes which provides robustness to wear and tear of the surface. This paper reports on the results of an experimental study that examines the challenges in building such barcodes and demonstrates the idea by constructing such a barcode.