gebhart/patrepeval huggingface dataset:
Alteration in 5HT1B receptor function by p11 in depression – like states. (2006)

International audience
Efficient Modeling of Piecewise Affine Systems in Model Predictive Control (2006)

This paper proposes a new approach to reducing the computational time for solving the model predictive control problem of discrete-time piecewise affine (DT-PWA) systems, by representing a finite automaton with the smallest number of binary variables. First, our method for modeling a finite automaton, which has been proposed in our previous paper, is explained. Next, an efficient modeling method of DT-PWA systems using mode transition constraints is proposed. Finally, the effectiveness of the proposed method is shown by numerical examples
MOS hydrogen sensors with ultrathin layers of palladium (1985)

MOS gas sensors were fabricated on n- and p-type silicon (5-7 Ω. cm) with thermal oxide layers ranging in thickness from 66 to 269 Å. A layer of palladium 30 Å thick was deposited through an evaporation mask. A layer of gold 350 Å thick was deposited over the palladium to provide a continuous electrical contact. Measurements were made of the capacitance at 1 MHz as a function of gasambient and time. The devices showed sensitivity to hydrogen at room temperature. Compared to devices fabricated with 300-Å layers of palladium, the thin film devices showed much faster response and recovery at room temperature and reduced magnitude of response. Devices fabricated on p-type silicon were noticably faster than those fabricated on n-silicon. First-order reaction kinetic fits showed general agreement with the data.
Production of lentiviral vectors by large‐scale transient transfection of suspension cultures and affinity chromatography purification (2007)

The use of lentiviral vectors as gene delivery vehicles has become increasingly popular in recent years. The growing interest in these vectors has created a strong demand for large volumes of vector stocks, which entails the need for scaleable vector manufacturing procedures. In this work, we present a simple and robust process for the production of lentiviral vectors using scaleable production and purification methodologies. Lentivirus particles were produced by transient transfection of serum-free suspension-growing 293 EBNA-1 cells with four plasmids encoding the vector components using linear polyethylenimine (PEI) as transfection reagent. This process was successfully scaled-up from shake flasks to a 3-L bioreactor from which 10(10) IVP were recovered. In addition, an affinity chromatography protocol designed for purification of bioactive oncoretroviral vectors has been adapted in this work for the purification of VSV-G pseudotyped lentiviral vectors. Using heparin affinity chromatography, lentiviral particles were concentrated and purified directly from the clarified supernatants. During this step, a recovery of 53% of infective lentiviral particles was achieved while removing 94% of the impurities contained in the supernatant.
Pulsed NMR study of the structure of poly(vinyl alcohol)‐poly(sodium acrylate) composite hydrogel (1994)

Abstract The heterogeneous structure of poly(vinyl alcohol)‐poly(sodium acrylate) composite hydrogels (PVA‐PAA gels), prepared by repeatedly freezing and thawing mixed aqueous solutions of PVA and PAA, has been studied using pulsed NMR. The free induction decay (FID) signals of the transverse magnetization for the PVA‐PAA gels were measured by both Carr‐Purcell‐Meiboom‐Gill and solid‐echo pulse sequences. The FID signal was decomposed into two or three decaying signals with various spin‐spin relaxation times, based upon differences in the molecular mobility that reflected structural heterogeneity. The structural heterogeneity of the PVA‐PAA gel is quite different from that of PVA gel free of PAA. We have made observations on “crosslinked” domains in the PVA‐PAA gels. They are formed by PVA solid chains, probably phase‐separated in the freezing‐thawing process. The formation of crosslinked domains is influenced by the number of freezing‐thawing cycles. © 1994 John Wiley & Sons, Inc.
SS‐31 Provides Neuroprotection by Reversing Mitochondrial Dysfunction after Traumatic Brain Injury (2018)

SS-31, a novel mitochondria-targeted peptide, has been proven to provide neuroprotection in a variety of neurological diseases. Its role as a mitochondrial reactive oxygen species (ROS) scavenger and the underlying pathophysiological mechanisms in traumatic brain injury (TBI) are still not well understood. The aim of the designed study was to investigate the potential neuroprotective effects of SS-31 and fulfill our understanding of the process of the mitochondrial change in the modified Marmarou weight-drop model of TBI. Mice were randomly divided into sham, TBI, TBI + vehicle, and TBI + SS-31 groups in this study. Peptide SS-31 (5 mg/kg) or vehicle was intraperitoneally administrated 30 min after TBI with brain samples harvested 24 h later for further analysis. SS-31 treatment significantly reversed mitochondrial dysfunction and ameliorated secondary brain injury caused by TBI. SS-31 can directly decrease the ROS content, restore the activity of superoxide dismutase (SOD), and decrease the level of malondialdehyde (MDA) and the release of cytochrome c, thus attenuating neurological deficits, brain water content, DNA damage, and neural apoptosis. Moreover, SS-31 restored the expression of SIRT1 and upregulated the nuclear translocation of PGC-1<i>α</i>, which were proved by Western blot and immunohistochemistry. Taken together, these data demonstrate that SS-31 improves the mitochondrial function and provides neuroprotection in mice after TBI potentially through enhanced mitochondrial rebiogenesis. The present study gives us an implication for further clinical research.
Proliferation-Attenuating and Apoptosis-Inducing Effects of Tryptanthrin on Human Chronic Myeloid Leukemia K562 Cell Line in Vitro (2011)

Tryptanthrin, a kind of indole quinazoline alkaloid, has been shown to exhibit anti-microbial, anti-inflammation and anti-tumor effects both in vivo and in vitro. However, its biological activity on human chronic myeloid leukemia cell line K562 is not fully understood. In the present study, we investigated the proliferation-attenuating and apoptosis-inducing effects of tryptanthrin on leukemia K562 cells in vitro and explored the underlying mechanisms. The results showed that tryptanthrin could significantly inhibit K562 cells proliferation in a time- and dose-dependent manner as evidenced by MTT assay and flow cytometry analysis. We also observed pyknosis, chromatin margination and the formation of apoptotic bodies in the presence of tryptanthrin under the electron microscope. Nuclei fragmentation and condensation by Hoechst 33258 staining were detected as well. The amount of apoptotic cells significantly increased whereas the mitochondrial membrane potential decreased dramatically after tryptanthrin exposure. K562 cells in the tryptanthrin treated group exhibited an increase in cytosol cyt-c, Bax and activated caspase-3 expression while a decrease in Bcl-2, mito cyt-c and pro-caspase-3 contents. However, the changes of pro-caspase-3 and activated caspase-3 could be abolished by a pan-caspase inhibitor ZVAD-FMK. These results suggest that tryptanthrin has proliferation-attenuating and apoptosis-inducing effects on K562 cells. The underlying mechanism is probably attributed to the reduction in mitochondria membrane potential, the release of mito cyt-c and pro-caspase-3 activation.
Biochemistry of redox reactions (1995)

Xenobiotic Metabolism: The Global View. Xenobiotic Metabolism: The Biochemical View. Dehydrogenation of Alcohols and Aldehydes, Carbonyl Reduction. The Nature and Functioning of Cytochromes P450 and Flavin-Containing-Monooxygenases. Carbon Oxidations Catalyzed by Cytochromes P450. Monooxygenase-Catalyzed N-C Cleavage. Monooxygenase-Catalyzed Oxidation of Oxygen- and Sulfur-Containing Compounds. Oxidative Dehalogenation and Dealkylation of Organometallics. Oxidations Catalyzed by Various Oxidases and Monooxygenases. Reactions Catalyzed by Peroxidases. Oxidation of Mercury, Silicon, Phosphorus, Arsenic, Selenium, and Halogens. Reductions Catalyzed by Cytochrome P450 and Other Oxidoreductases. Various Enzymatic and Nonenzymatic Reactions. Conclusion and Outlook.
Acquisition of verb entailment from text (2006)

The study addresses the problem of automatic acquisition of entailment relations between verbs. While this task has much in common with paraphrases acquisition which aims to discover semantic equivalence between verbs, the main challenge of entailment acquisition is to capture asymmetric, or directional, relations. Motivated by the intuition that it often under-lies the local structure of coherent text, we develop a method that discovers verb entailment using evidence about discourse relations between clauses available in a parsed corpus. In comparison with earlier work, the proposed method covers a much wider range of verb entailment types and learns the mapping between verbs with highly varied argument structures.
Guanine nucleotide-binding activity as an assay for <i>src</i> protein of rat-derived murine sarcoma viruses (1979)

We have recently identified a 21,000-dalton protein, p21, coded for by Kirsten or Harvey murine sarcoma virus. On the basis of the results obtained with the p21 of a mutant of Kirsten sarcoma virus, temperature sensitive for the maintenance of transformation, we concluded that the p21 was required for the maintenance of transformation induced by either virus. We report herein that when extracts from cells transformed by Kirsten or Harvey sarcoma virus are incubated with [(3)H]GDP or [alpha-(32)P]GTP, picomole quantities of guanine nucleotide can be immunoprecipitated with antisera that contain antibodies to the p21. Previously we have shown that the immunoprecipitability of [(35)S]methionine-labeled p21 of the temperature-sensitive mutant of Kirsten sarcoma virus is thermolabile. The binding of guanine nucleotide is shown herein also to be thermolabile in extracts of cells transformed by the same mutant. However, the immunoprecipitability of the [(35)S]methionine-labeled p21 in such extracts of the temperature-sensitive mutant can be preserved if the extracts containing labeled p21 are incubated with added GDP or GTP prior to heating. The results suggest an interaction between p21 and certain guanine nucleotides, and the possible roles of guanine nucleotides and p21 in the maintenance of transformation are discussed.
A Simplified Synthesis of the Diastereomers of Levuglandin E<sub>2</sub> (2005)

Abstract We report a synthesis of Levuglandin E2, as a mixture of easily separable diastereomers (15‐E2‐isoketals). The key feature is the protection of its reactive aldehyde as dimethyl acetal, which is introduced with 2,2‐dimethoxyethanal and removed in minutes with Montmorillonite K‐10. The synthesis could be modified to the preparation of 15‐E2‐isoketals with stable isotopes or with radiolabels.
Damping controller input-signal loss effects on the wide-area stability of an interconnected power system (2002)

Most countries in different parts of the world are getting closer to electricity industry deregulation. Deregulation has induced increase in network power transfers thus resulting in more constraint on power system oscillations. Now in big interconnected networks, the scope is becoming larger and larger. For instance, to cope with inter-area oscillations, power controllers need a more global vision (when a remote input signal is used in a power system stabiliser to damp inter-area oscillations). But in the perspective of deregulation, the knowledge of distant signals will not be guaranteed any more. This paper explores the problem of remote input signal loss for a remote feedback controller (RFC) used to damp inter-area oscillations in power systems. The similarity of the machine responses in the two areas oscillating against each other is used. The RFC is designed to be robust and effective when presented with the loss of one or many input signals. This performance is accomplished through the inclusion of synchronised measurements (GPS) from several points in the power system. The proposed signal-loss solutions are verified via small-signal analysis and dynamic simulations on both a 4- and 29-machines test power system.
Two-Dimensional Parallel Dispenser for Microarray Printing (2003)

Parallel printing in a microarray format is becoming increasingly important. This paper presents a 2-D multi-channel dispenser with a spotting spacing of 500 μm. The dispenser is continuously loaded from a 384-well plate format and shoots upward. New technologies using polyimide substrate was developed, and the flexibility of the polyimide sheets allows scaling the dispenser up to an array format of 24 × 16. Drop formation is analyzed by stroboscopic illumination and by spotting onto glass slides. Droplets of 65 pL are dispensed in parallel up to 5 kHz at a droplet speed of 2 m/s.
High efficiency proton beam generation through target thickness control in femtosecond laser-plasma interactions (2014)

Bright proton beams with maximum energies of up to 30 MeV have been observed in an experiment investigating ion sheath acceleration driven by a short pulse (&lt;50 fs) laser. The scaling of maximum proton energy and total beam energy content at ultra-high intensities of ∼1021 W cm−2 was investigated, with the interplay between target thickness and laser pre-pulse found to be a key factor. While the maximum proton energies observed were maximised for μm-thick targets, the total proton energy content was seen to peak for thinner, 500 nm, foils. The total proton beam energy reached up to 440 mJ (a conversion efficiency of 4%), marking a significant step forward for many laser-driven ion applications. The experimental results are supported by hydrodynamic and particle-in-cell simulations.
Spongelike Structures of Hexa-<i>peri</i>-hexabenzocoronene Derivatives Enhance the Sensitivity of Chemiresistive Carbon Nanotubes to Nonpolar Volatile Organic Compounds of Cancer (2009)

Cancer is a leading health hazard, and lung cancer is its most common form. Breath testing is a fast, noninvasive diagnostic method which links specific volatile organic compounds (VOCs) in exhaled breath to medical conditions. Arrays of sensors based on carbon nanotubes (CNTs) could in principle detect cancer by differentiating between the VOCs found in the breath of healthy and sick persons, but the notoriously low sensitivity of CNT sensors to nonpolar VOCs limits their accuracy. In this study, we have achieved a marked improvement of the sensitivity and selectivity of random networks (RNs) of CNT chemiresistors to nonpolar VOCs by functionalizing them with self-assembled, spongelike structures of discotic hexa-peri-hexabenzocoronene (HBC) derivatives. We observed swelling of the organic film by monitoring the changes of organic film thickness during exposure and propose that the expansion of the spongelike organic overlayer creates scattering centers in the underlying RN-CNTs by physically distancing the CNTs at their intersections. The results presented here could lead to the development of robust sensors for nonpolar VOCs of cancer breath, which have hitherto been difficult to trace.
Health-Related Quality of Life as a Predictor of Mortality Following Coronary Artery Bypass Graft Surgery (1999)

The Physical Component Summary score from the preoperative SF-36 is an independent risk factor for mortality following CABG surgery. The baseline Mental Component Summary score does not appear to be predictive of mortality. Preoperative patient self-report of the physical component of health status may be helpful for risk stratification and clinical decision making for patients undergoing CABG surgery.
Durable and regenerable antimicrobial textiles: Improving efficacy and durability of biocidal functions (2003)

Abstract 2,2,5,5‐Tetramethylimidazolidinone (TMIO)‐modified cotton‐containing fabrics could provide excellent durable antimicrobial properties, but the biocidal speeds were low because of its amine halamine structures. To prepare biocidal fabrics that can inactivate microorganisms rapidly and survive repeated laundering and long duration of storage, 3‐methylol‐2,2,5,5‐tetramethylimidazolidinone and dimethylol‐5,5‐dimethylhydantoin were combined in different ratios in chemical modifications of cellulose fabrics. The mixtures of TMIO and hydantoin rings on the grafted cellulose provided a hybrid of imide, amide, and amine halamine structures in different ratios after chlorination, and led to varied efficacy and durability of biocidal properties on the finished fabrics. The effect of the combined halamine structures on biocidal efficacy and durability of the fabrics were discussed in this article. © 2003 Wiley Periodicals, Inc. J Appl Polym Sci 91: 2588‐2593, 2004
Effect of water sprays for respirable dust suppression with a research continuous-mining machine. Report of investigations, 1978 (1978)

A field test program was conducted in the Pittsburgh coal seam to investigate the effect of water sprays in the suppression of respirable dust being formed while cutting with a LN 456 continuous mining machine. Emphasis was given to the location of spray nozzles on the top and bottom of the cutting boom. Results showed that (1) sump causes about 60 percent of the dust escaping the face area and shear/load causes the other 40 percent, (2) during sump, top and bottom sprays were equally effective in dust suppression and reduced dust by approximately 13 percent, (3) during shear/load, bottom sprays reduced dust by 51 percent and were about 50 percent more effective than top sprays, (4) the combination of top and bottom sprays was slightly more effective than the separate systems but water consumption increased 60 percent, and (5) inclusion of throat sprays resulted in a decrease in dust reduction by removing some of the water from top and bottom sprays where it was more effective.
A randomized blinded trial of combination therapy with cyclophosphamide in patients with active multiple sclerosis on interferon beta (2005)

Combination therapy with CY/MP and IFNbeta-Ia decreased the number of Gd+ lesions and slowed clinical activity in patients with previously active disease on IFNbeta alone.
Palmitoylation of the luteinizing hormone/human chorionic gonadotropin receptor regulates receptor interaction with the arrestin-mediated internalization pathway (2001)

The luteinizing hormone/human chorionic gonadotropin receptor (LH/hCGR) undergoes palmitoylation at cysteine residues 621 and 622 located in the carboxyl terminal tail of the receptor.This study examined the biological function of palmitoylation with respect to its effect on receptor internalization.Coexpression of wild-type (WT) or C621/ 622G mutant receptors with arrestin-2 increased receptor internalization in 293T cells.Furthermore, measurements of rate enhancement upon overexpression of arrestin indicate that the palmitoylation deficient mutant receptor is more prone to utilizing the arrestin mediated internalization pathway than the WT receptor.Coexpression of G-protein-coupled receptor kinase 4 (GRK4) with wild type receptor resulted in an increase in internalization, while coexpression with the mutant receptor did not result in further enhancement of internalization.Additionally, 293T cells expressing mutant receptor were responsive to hCG with respect to production of inositol phosphates.Taken together, these results suggest that the palmitoylation state of the receptor governs internalization by regulating the accessibility of the receptor to the arrestin-mediated internalization pathway.
Electro-optic X-switch using single-mode Ti:LiNbO <sub>3</sub> channel waveguides (1983)

A new type of single-mode four-port electro-optic switch is investigated. The operation principle is based on the electrically controlled two-mode interference in the intersection region of two crossing single-mode channel waveguides. The switch is analysed numerically by the beam-propagation method, and is realised experimentally by using Ti:LiNbO3 channel waveguides.
The diminished production of arachidonic acid oxygenation products by elicited mouse peritoneal macrophages: possible mechanisms. (1980)

Abstract Resident and elicited populations of mononuclear phagocytes differ in their capacity to secrete various products relevant to immune and inflammatory responses. We compared the release of prostaglandins by elicited and resident macrophage populations. Resident populations of peritoneal macrophages were obtained from specific pathogen-free mice and elicited populations from mice that had received i.p. injections of thioglycollate broth, BCG, or CP. Macrophages obtained by enzymatic dispersion of 7-day-old-carrageenan granulomas were also studied. Resident macrophages release large amounts of PGE2 and 6-keto-PGF1α when challenged in culture with zymosan. Elicited and granuloma macrophages are far less responsive to zymosan as reflected by decreased release of PG. Resident macrophages give a 42-fold increase in PGE2 release when exposed for 4 hr to 50 jug/ml of zymosan compared with only a 5-fold increase in PGE2 release by thioglycollate-elicited macrophages exposed to 300 μg/ml. A similar loss of reactivity to zymosan in terms of PG release was found with macrophages from BCG- or CP-treated mice. Elicited and resident cells are also clearly differentiated by the activity of certain cell associated enzymes. Elicited cells from BCG, CP, thioglycollate, and carrageenan-treated mice showed decreased 5’-nucleotidase and elevated leucine aminopeptidase activities compared with resident cells. Some of the possible mechanisms accounting for these differences in PG production have been examined by examining several parameters that may regulate PG production. There are no indications that phagocytic capacity or the ability to release or sequester PG accounted for the differences observed. Measurement of lipid deacylation rates showed a marked decrease of the rates of arachidonic acid release from thioglycollate-elicited cells compared with resident cells.
Aggregating Bills and Invoices on Cloud for Anytime Anywhere Access: A Sustainable System (2012)

Access to cloud storage devices and services (IaaS or RaaS) are getting popular because of their anytime-anywhere flexibility and low cost. Cloud storage enables networked online storage where data is stored in virtualized pools of storage units. These units are usually managed by third parties. It is being used for the purpose of storing music files, presentations, statements, bills and other important documents. Organizations like Google, Amazon, Rackspace, and Dropbox are providing on-cloud storage. Besides organizations this service is gaining popularity among end-users too. Typically a user scans his important documents and store at the subscribed space. Later these documents can be accessed using an internet browser. Since user manages his own documents, there are chances that certain important documents are missed out. Hence we need an automatic storage system which can save these bills and invoices at the targeted location as soon as they are generated. In this article we are presenting the simplified model along with the improved process flow chart and architecture details. The proposed system would reduce the chances of missed documents and unnecessary troubles of scanning them. Additionally whenever required the user can provide the access code of the particular bill to the concerned authority for any verifications and approvals. This would also help to save the printing and paper cost for the retailer as well as for the user, further contributing towards the environment and sustainability. Using the proposed system the user can simply point to that URL and hence he/she need not print the bliss. This would also prevent the production of frauds and forged bills.