gebhart/patrepeval huggingface dataset:
Four and a Half LIM Protein 1 Binds Myosin-binding Protein C and Regulates Myosin Filament Formation and Sarcomere Assembly (2006)

Four and a half LIM protein 1 (FHL1/SLIM1) is highly expressed in skeletal and cardiac muscle; however, the function of FHL1 remains unknown. Yeast two-hybrid screening identified slow type skeletal myosin-binding protein C as an FHL1 binding partner. Myosin-binding protein C is the major myosin-associated protein in striated muscle that enhances the lateral association and stabilization of myosin thick filaments and regulates actomyosin interactions. The interaction between FHL1 and myosin-binding protein C was confirmed using co-immunoprecipitation of recombinant and endogenous proteins. Recombinant FHL2 and FHL3 also bound myosin-binding protein C. FHL1 impaired co-sedimentation of myosin-binding protein C with reconstituted myosin filaments, suggesting FHL1 may compete with myosin for binding to myosin-binding protein C. In intact skeletal muscle and isolated myofibrils, FHL1 localized to the I-band, M-line, and sarcolemma, co-localizing with myosin-binding protein C at the sarcolemma in intact skeletal muscle. Furthermore, in isolated myofibrils FHL1 staining at the M-line appeared to extend partially into the C-zone of the A-band, where it co-localized with myosin-binding protein C. Overexpression of FHL1 in differentiating C2C12 cells induced "sac-like" myotube formation (myosac), associated with impaired Z-line and myosin thick filament assembly. This phenotype was rescued by co-expression of myosin-binding protein C. FHL1 knockdown using RNAi resulted in impaired myosin thick filament formation associated with reduced incorporation of myosin-binding protein C into the sarcomere. This study identified FHL1 as a novel regulator of myosin-binding protein C activity and indicates a role for FHL1 in sarcomere assembly.
Activation and Degradation of the Transcription Factor C/EBP During Long‐Term Facilitation in <i>Aplysia</i> (1999)

Long-term facilitation (LTF) of the sensory-to-motor synapses that mediate defensive reflexes in Aplysia requires induction of the transcription factor Aplysia CCAAT/enhancer binding protein (ApC/EBP) as an early response gene. We examined the time course of ApC/ EBP DNA binding during the induction of LTF: Binding activity was detected within 1 h of the sensitization treatment with serotonin, reached a maximum at 2 h, and decreased after 6 h. How are DNA binding and the turnover of ApC/EBP regulated? We find that phosphorylation of ApC/EBP by mitogen-activated protein (MAP) kinase is essential for binding. MAP kinase appears to be activated through protein kinase C. We also showed that ApC/EBP is degraded through the ubiquitin-proteasome pathway but that phosphorylation by MAP kinase renders it resistant to proteolysis. Thus, phosphorylation by MAP kinase is required for ApC/EBP to act as a transcription activator as well as to assure its stability early in the consolidation phase, when genes essential for the development of LTF begin to be expressed.
Guest−Host Cooperativity in Organic Materials Greatly Enhances the Nonlinear Optical Response (2008)

Some of the most highly active organic electro-optic (EO) materials developed recently rely on the combination of an EO-active (chromophore-containing) host material (dendrimer or side-chain polymer) and an EO-active (chromophore) guest. These new binary-chromophore materials exhibit EO coefficients (r33) in the range of 250 to greater than 300 pm/V (currently as high as 450 pm/V). The EO activity of these binary-chromophore materials is greater the sum of their individual components. The experimentally observed increase in the nonlinear optical response of two representative classes of EO chromophore−EO dendrimer and EO chromophore−EO polymer mixtures relative to the response of the isolated components is described quantitatively herein by a physical model that accounts for cooperativity in the guest−host interactions.
Scale invariant feature matching with wide angle images (2007)

Numerous scale-invariant feature matching algorithms using scale-space analysis have been proposed for use with perspective cameras, where scale-space is defined as convolution with a Gaussian. The contribution of this work is a method suitable for use with wide angle cameras. Given an input image, we map it to the unit sphere and obtain scale-space images by convolution with the solution of the spherical diffusion equation on the sphere which we implement in the spherical Fourier domain. Using such an approach, the scale-space response of a point in space is independent of its position on the image plane for a camera subject to pure rotation. Scale-invariant features are then found as local extrema in scale-space. Given this set of scale-invariant features, we then generate feature descriptors by considering a circular support region defined on the sphere whose size is selected relative to the feature scale. We compare our method to a naive implementation of SIFT where the image is treated as perspective, where our results show an improvement in matching performance.
The anti‐allergic compound tranilast attenuates inflammation and inhibits bone destruction in collagen‐induced arthritis in mice (2010)

Tranilast possesses significant anti-rheumatic efficacy and, probably, this therapeutic effect is partly mediated by inhibition of mast cell activation and osteoclastogenesis.
Notes from the Editor-in-Chief (2001)

Review of new models in Healthcare. Bridging the gap between the world of academia and the world of healthcare management and policy. Authors explore the potential of new ideas. Edited by Audrey Laporte, MA, PhD, Director, Institute for Health Policy Measurement and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON and Arjumand Siddiqi, MPH, ScD, Professor, Division Head of Epidemiology, Dalla Lana School of Public Health, Canada Research Chair in, Population Health Equity, University of Toronto, Toronto, ON
Barium titanate and barium strontium titanate coated carbon fibers for multifunctional structural capacitors (2012)

Multifunctional materials can increase the performance of a system through the integration of multiple separate functional components into a single material system. This design approach offers widespread benefits and can be applied to a variety of applications. Here, we explore the integration of electrostatic energy storage and composite materials through the growth of a barium strontium titanate film on carbon fiber. The perovskite ceramic offers high dielectric constant and the use of Ba x Sr 1 − x TiO 3 allows for the tuning of the dielectric, ferroelectric, and loss parameters to obtain an optimal energy storage stoichiometry. We have evaluated the dielectric and breakdown strength of the films to determine the energy storage density and demonstrate energy densities of 0.12 J/cc from a load-bearing fiber.
Interfacial Energy and the Molecular Structure of Organic Compunds III. The Effect of Organic Structure on Adsorbability (1935)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInterfacial Energy and the Molecular Structure of Organic Compunds III. The Effect of Organic Structure on AdsorbabilityEdward R. LinnerEdward R. LinnerMore by Edward R. Linner and Ross Aiken GortnerRoss Aiken GortnerMore by Ross Aiken GortnerCite this: J. Phys. Chem. 1935, 39, 1, 35–68Publication Date (Print):January 1, 1935Publication History Published online1 May 2002Published inissue 1 January 1935https://doi.org/10.1021/j150361a004RIGHTS & PERMISSIONSArticle Views123Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Get e-Alerts
Augmented Machine Learning Approach of Rate of Penetration Prediction for North Sea Oilfield (2020)

Abstract Rate of penetration (ROP) refers to penetration speed in drilling process, which is directly related to drilling cost and time. Therefore, ROP optimization by choosing the best drilling parameters has been an important issue in drilling fields to cut cost and spend less time in drilling. To optimize ROP in an accurate and efficient manner, an accurate ROP prediction should precede. An accurate ROP prediction makes optimizing drilling parameters possible, which leads to cost-effective drilling. Recently, the development of machine learning brings new insight into various fields including petroleum engineering, where conventional and domain knowledge-based equations were dominant. Particularly, leveraging deep neural networks that are highly capable of representing complex relationship of features has shown promising results in various tasks and fields such as computer vision and language modeling. In this paper, we present a novel machine learning model for the ROP prediction. We focused on developing a model which is trained with offset well logs data to predict ROP of unseen target wells within the same field. By utilizing the state-of-the-art deep neural networks specialized in sequential data process, we show that the data driven ROP prediction significantly outperforms conventional ROP prediction methods. In addition, we utilized a stacked generalization ensemble method that integrates several ROP prediction models to produce an optimal ROP prediction model. We also show that our stacked ensemble model can improve prediction performance of a single model.
Modelling of electroabsorption in coupled quantum wells with applications to low voltage optical modulation (1990)

The authors model the room temperature electroabsorption of coupled double quantum wells using a transfer matrix technique to calculate carrier wavefunctions and their overlaps. Their behaviour with an electric field is compared with uncoupled multiple quantum wells with optical modulation in mind. Consideration of wavefunctions and energy levels allows them to choose a coupled well structure with good optical modulation at a low electric field. By fitting three parameters once, they predict absorption spectra. These are used to assess coupled quantum wells within an asymmetric Fabry-Perot reflection modulator. Very low voltage operating characteristics were calculated allowing for a total fluctuation in the coupling barrier width of one monolayer: a contrast ratio of 2.1:1, an insertion loss of 3.3 dB and an applied voltage of only 0.7 V; alternatively, a very high contrast with an insertion loss of 9.4 dB operating at 2.2 V. However, these predictions may be difficult to fulfil in devices grown at present because of the built-in field within the intrinsic region of a p-i-n diode.
Physics of SiC MOS interface and development of trench MOSFETs (2013)

An original method to accurately evaluate the MOS interface state density has been proposed. Characterization using this method has revealed that a high density of fast states is generated by interface nitridation of SiC(0001), though the density of slow interface states can be remarkably reduced by the nitridation. The generation of fast states is less pronounced on non-basal planes of SiC, and high channel mobilities over 100 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> /Vs are obtained for MOSFETs fabricated on Al <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+</sup> -implanted SiC(11-20) and (1-100). We also proposed a novel design of “double-trench” MOSFET, which is effective to alleviate the electric field crowding at the gate oxide near the trench bottom. Based on these fundamental investigations combined with advanced device technology, we achieved a very low on-resistance of 0.79 mΩcm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> for a 630 V SiC trench MOSFET (normally off).
Dynamic Control of Chiral Space in a Catalytic Asymmetric Reaction Using a Molecular Motor (2011)

Enzymes and synthetic chiral catalysts have found widespread application to produce single enantiomers, but in situ switching of the chiral preference of a catalytic system is very difficult to achieve. Here, we report on a light-driven molecular motor with integrated catalytic functions in which the stepwise change in configuration during a 360° unidirectional rotary cycle governs the catalyst performance both with respect to activity and absolute stereocontrol in an asymmetric transformation. During one full rotary cycle, catalysts are formed that provide either racemic (R,S) or preferentially the R or the S enantiomer of the chiral product of a conjugate addition reaction. This catalytic system demonstrates how different molecular tasks can be performed in a sequential manner, with the sequence controlled by the directionality of a rotary cycle.
Seismic Response of Multistory Building Structures With Flexible Floor Diaphragms (1989)

An efficient model for three-dimensional analysis of multistory structures with flexible floor diaphragms is proposed in this paper. Three-dimensional analysis of a building structure using a finite element model requires tedious input data preparation, longer computation time, and larger computer memory. The model proposed in this study is developed by assembling a series of two-dimensional resisting systems and is considered to overcome the shortcomings of a three-dimensional finite element model without deteriorating the accuracy of results. Static and dynamic analysis results obtained using the proposed model are in excellent agreement to those obtained using three-dimensional finite element models in terms of displacements, periods, and mode shapes. Effects of floor diaphragm flexibility on seismic response of multistory building structures are investigated.
Heart rate adjustment of ST segment depression for improved detection of coronary artery disease. (1989)

Normal values for heart rate-adjusted indexes of ST segment depression during treadmill exercise electrocardiography (the ST segment/heart rate slope and the delta ST segment/heart rate index) were derived from evaluation of 150 subjects with a low likelihood of coronary artery disease, including 100 normal subjects and 50 subjects with nonanginal chest pain. Partitions chosen by the method of percentile estimation to include 95% of normal subjects remained highly specific in subjects with nonanginal pain syndromes. Sensitivities of the derived partitions for detection of myocardial ischemia were tested in an additional 150 patients with a high likelihood of coronary disease, including 100 patients with angiographically demonstrated coronary obstruction and 50 patients with stable angina. In contrast to the 68% (102 of 150 subjects) sensitivity of standard exercise electrocardiographic criteria for the detection of disease in this population, the sensitivity of an ST segment/heart rate slope partition of 2.4 muV/beats/min was 95% (142 of 150 subjects, p less than 0.001), and the sensitivity of a delta ST segment/heart rate index partition of 1.6 muV/beats/min was 91% (137 of 150 subjects, p less than 0.001). Analysis of receiver-operating curves confirmed the superior performance of the heart rate-adjusted indexes throughout a wide range of test specificities. These findings suggest that heart rate adjustment of ST segment depression can markedly improve the clinical usefulness of the treadmill exercise electrocardiogram.
Protective Roles of B and T Lymphocyte Attenuator in NKT Cell-Mediated Experimental Hepatitis (2009)

Although B and T lymphocyte attenuator (BTLA) was originally identified as an inhibitory coreceptor selectively expressed on Th1 cells and B cells, recent studies have revealed that BTLA is expressed on a variety of cells, including macrophages, dendritic cells, and NK cells, and modulates their functions. However, the role of BTLA in the regulation of NKT cell function remains unknown. In this study, we found that BTLA was expressed on NKT cells at the levels similar to those on T cells and that BTLA-deficient (BTLA(-/-)) NKT cells produced larger amounts of IL-4 and IFN-gamma upon alpha-glactosylceramide stimulation as compared with wild-type (WT) NKT cells. In vivo, BTLA(-/-) mice produced larger amounts of IL-4 and IFN-gamma upon Con A injection and were more susceptible to Con A-induced hepatitis than WT mice. In addition, the augmentation of Con A-induced hepatitis in BTLA(-/-) mice was not observed in BTLA/NKT-double deficient mice. Moreover, NKT(-/-) mice reconstituted with BTLA(-/-) NKT cells were significantly more susceptible to Con A-induced hepatitis as compared with NKT (-/-) mice reconstituted with WT NKT cells. These results suggest that BTLA functions as the inhibitory coreceptor of NKT cells and plays a critical role in the prevention of NKT cell-mediated liver injury.
Immune Abnormalities in Schizophrenia: Evidence for the Autoimmune Hypothesis (1994)

The autoimmune basis for schizophrenia has been investigated for the last 60 years. Although numerous immune abnormalities have been reported, the current literature is viewed with much skepticism because most of the studies have failed to control for extraneous factors that may have influenced the findings. Principally, antipsychotic medication, duration of illness, and current clinical state (acutely psychotic or remitted) may considerably alter immune response, as may other factors such as nutritional status, substance abuse, and concurrent medical illness. We review recent studies that employed current diagnostic criteria and modern immunologic techniques. (These studies were located by use of a Medline search on the terms schizophrenia and psychosis, cross-referenced with immune abnormalities, lymphokines, antibodies, lymphocytes, HLA, and medication, and by perusing the reference lists in the articles found through this search.) Immune abnormalities that have been replicated in studies of schizophrenic patients include increased prevalence of antinuclear antibodies, decreased production of interleukin-2, and increased serum concentrations of interleukin-2 receptor and interleukin-6. Given the current importance of autoimmunity as an etiologic mechanism in several branches of medicine, further studies are needed, especially those having a longitudinal design and including drug-naive patients.
Total synthesis of 8(S)-, 9(S)-, 11(S)-, and 12(S)-hydroxyeicosatetraenoic acids (HETE) methyl esters (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal synthesis of 8(S)-, 9(S)-, 11(S)-, and 12(S)-hydroxyeicosatetraenoic acids (HETE) methyl estersGeorge Just and Zhi Yuan WangCite this: J. Org. Chem. 1986, 51, 25, 4796–4802Publication Date (Print):December 1, 1986Publication History Published online1 May 2002Published inissue 1 December 1986https://pubs.acs.org/doi/10.1021/jo00375a009https://doi.org/10.1021/jo00375a009research-articleACS PublicationsRequest reuse permissionsArticle Views200Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Neutral-carrier-based magnesium-selective electrode (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNeutral-carrier-based magnesium-selective electrodeMarizel V. Rouilly, Martin. Badertscher, Ernoe. Pretsch, Gabriela. Suter, and Wilhelm. SimonCite this: Anal. Chem. 1988, 60, 19, 2013–2016Publication Date (Print):October 1, 1988Publication History Published online1 May 2002Published inissue 1 October 1988https://pubs.acs.org/doi/10.1021/ac00170a005https://doi.org/10.1021/ac00170a005research-articleACS PublicationsRequest reuse permissionsArticle Views162Altmetric-Citations38LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Keap1/Nrf2 pathway in the frontiers of cancer and non-cancer cell metabolism (2015)

Cancer cells adapt their metabolism to their increased needs for energy and substrates for protein, lipid and nucleic acid synthesis. Nuclear erythroid factor 2-like 2 (Nrf2) pathway is usually activated in cancers and has been suggested to promote cancer cell survival mainly by inducing a large battery of cytoprotective genes. This mini review focuses on metabolic pathways, beyond cytoprotection, which can be directly or indirectly regulated by Nrf2 in cancer cells to affect their survival. The pentose phosphate pathway (PPP) is enhanced by Nrf2 in cancers and aids their growth. PPP has also been found to be up-regulated in non-cancer tissues and other pathways, such as de novo lipogenesis, have been found to be repressed after activation of the Nrf2 pathway. The importance of these Nrf2-regulated metabolic pathways in cancer compared with non-cancer state remains to be determined. Last but not least, the importance of context about Nrf2 and cancer is highlighted as the Nrf2 pathway may be activated in cancers but its pharmacological activators are useful in chemoprevention.
Generalized Pilot Assisted Channel Estimation For Wcdma (2005)

Publication in the conference proceedings of EUSIPCO, Antalya, Turkey, 2005
Determination of Total Tissue Sodium Concentrations by Use of Radiosodium (1955)

A method has been developed for the estimate of total tissue sodium by direct measurement of radiosodium concentrations in undigested samples. Accuracy is comparable to that of flame photometric estimates on tissue digests; time and cost, about one-quarter as great. The method appears particularly useful for experimental designs requiring multiple tissue sodium measurements.