gebhart/patrepeval huggingface dataset:
Superantigen‐induced cytokines suppress growth of human colon‐carcinoma cells (1993)

We have recently demonstrated that the superantigen staphylococcal enterotoxin A (SEA) conjugated to colon-carcinoma-reactive monoclonal antibodies (MAbs) directs T cells to lyse human colon-carcinoma cells, representing a potential novel tumor therapy. To further analyze the mechanism of antitumor effects of superantigen-activated T cells, we compared the activity of free and MAb-conjugated SEA in a long term in vitro co-culture assay of human peripheral-blood mononuclear cells (PBMC) and colon-carcinoma cell lines. Activation of resting T lymphocytes with SEA conjugated to the colon-carcinoma-reactive MAb C215 or free SEA resulted in strong inhibition of the growth of all studied colon-carcinoma cell lines. The growth of WiDr colon-carcinoma cells was unaffected by the presence of unactivated mononuclear cells, whereas addition of pM concentrations of SEA or C215-SEA conjugate completely suppressed tumor-cell growth. The suppressive effect was mediated by both CD4+ and CD8+ T cells and required the presence of MHC-Class II+ monocytes. The inhibition of tumor-cell growth was to a large extent mediated by soluble factors present in supernatants from SEA- or C215-SEA-activated mononuclear cells. Quantitation of cytokine mRNA in SEA-activated mononuclear cells by the reverse transcriptase-polymerase chain reaction (RT-PCR) revealed strong induction of mRNA encoding the cytokines IL-1 alpha, IL-1 beta, IL-2, IL-6, TNF-alpha, TNF-beta and IFN-gamma. The use of cytokine-specific MAb demonstrated that IFN-gamma was of major importance for the tumor-growth-inhibitory activity in supernatants of SEA-activated lymphocytes. Addition of recombinant cytokines to WiDr colon-carcinoma cells showed that TNF-alpha was able to act synergistically with IFN-gamma to suppress tumor-cell growth. The local production of tumor-suppressive cytokines induced by MAb-targeted superantigens is likely to be of particular relevance for inhibition of the growth of tumor cells not expressing the targeted tumor-associated antigen.
<title>Fiber channel: the next standard peripheral interface and more</title> (1991)

Fiber Channel (FC) is a new " physical interface" designed to carry the command sets associated with the existing SCSI IPI HIPPI and IBM Block Mux channels. FC supports multiple technologies to obtain different cost and performance levels - up to 102. 5 megabaud over 2 km. FC has a single " framing protocol" and uses the IBM 8B/1OB coding scheme. The background to the ANSI effort and the potential market will also be described.
YIG resonators and filters (1985)

A comprehensive examination of single crystal yttrium iron garnet and gallium-substituted magnetic insulators. Treating all aspects of system theory, design, and application, chapters cover the microwave gyrator, uniform mode, magnetostatic modes, spinwave modes, crystalline anisotropy, non-linear theory, measurement, open-circuit parameters, unloaded, external, and loaded Q-factors, and more.
Physical Activity, Physical Fitness, and Risk of Type 2 Diabetes Mellitus (2005)

Type 2 diabetes mellitus (DM) is a common chronic disease. Cardiovascular disease is the most prevalent complication of DM. In the past decade, the associations of physical activity, physical fitness, and changes in lifestyle with the risk of type 2 DM have been assessed by a number of prospective epidemiologic studies and clinical trials. Several studies also evaluate the joint associations of physical activity, body mass index, and glucose levels with the risk of type 2 DM. The results of 21 prospective studies and four clinical trials demonstrated that moderate or high levels of physical activity or physical fitness, as well as changes in lifestyle (dietary modification and enhanced physical activity) could prevent type 2 DM.
Daylesford: S. P. Cockerell's Residence for Warren Hastings (1963)

Research Article| October 01 1963 Daylesford: S. P. Cockerell's Residence for Warren Hastings Paul F. Norton Paul F. Norton Search for other works by this author on: This Site PubMed Google Scholar Journal of the Society of Architectural Historians (1963) 22 (3): 127–133. https://doi.org/10.2307/988223 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Paul F. Norton; Daylesford: S. P. Cockerell's Residence for Warren Hastings. Journal of the Society of Architectural Historians 1 October 1963; 22 (3): 127–133. doi: https://doi.org/10.2307/988223 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu nav search search input Search input auto suggest search filter All ContentJournal of the Society of Architectural Historians Search This content is only available via PDF. Copyright 1963 The Society of Architectural Historians Article PDF first page preview Close Modal You do not currently have access to this content.
[Enrichment of haploid spermatids in mice by flow sorting]. (2014)

Flow sorting can efficiently improve the purity of haploid spermatid enrichment, which helps a lot to elucidate the mechanisms of spermiogenesis.
Comparisons and Analysis on Architectural Features of Seven Typical Traditional Dwellings in China (2014)

The ancestors of China created various proper dwellings in the vast Chinese lands, according to distinct geographical environment, climate, and special local products. The purpose of this study is to compare features of 7 typical traditional Chinese dwellings in different areas from historical, geographical, structural and tinctorial aspects, in order to see what the differences are and rearrange them by these 4 different scales as estimate standards. By Comparing features between 7 traditional dwellings, advantages and disadvantages of them were found out. Not only natural terrain but also cultural mentality is an important factor that effected on the changes of regionality. The result showed that historical length in a certain extent reflected the differences between dwellings in different areas; there are more regular type dwellings in the northern China; dwellings in different structural material types following their regions; and, southern dwellings prefer natural and simple exterior colors. Also From construction aesthetics and culture perspective, Different cultures have cultivated and brought out different dwelling styles. Thus, protecting on traditional dwellings is of great necessities and this study will bring benefits in many aspects. For a further research, the result of this study can be utilized as the base data that suggest directions for effective Chinese residence planning in different areas meeting different demands.
Surface modification of silicone rubber by ion beam assisted deposition (IBAD) for improved biocompatibility (2005)

Abstract We studied the preparation of antimicrobial silicone rubbers of improved interfacial strength, which could be formed with the ion beam assisted deposition (IBAD) technique for coating metallic or inorganic materials (silver (Ag), Copper (Cu), and Hydroxyapatite(HAp)/TiO 2 ) on the silicone surface. Those coating materials provide high product safety as well as outstanding antimicrobial activity. The deposition methodology is composed of pre‐etching with oxygen gas, vaporizing the coating materials, and post‐treatment with Ar ion. With the evaporation of the coating materials, the Ar beam was focused on the substrate to assist deposition. It was found out that the ion assisting depositions in the IBAD process give a prominent enhancement in adhesion between silicone rubbers and coatings of Ag and Cu. The HAp/TiO 2 coating layer was easily dissolved in aqueous saline solution. All deposited layers display high antimicrobial activities against Staphlococcus aureus (ATCC 6538) and Escherichia coil (ATCC 25,922), showing 99.9% reduction of bacteria, respectively. In a cytotoxicity test, the Ag and HAp/TiO 2 coated silicone shows a decrease of cytotoxicity, while the Cu coating leads to a slight increase of cytotoxicity. The result on the surface modifications of silicone rubber will be employed in further study for applications of medical or rehabilitation devices. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci 96: 1095–1101, 2005
Potential for control of detrusor smooth muscle spontaneous rhythmic contraction by cyclooxygenase products released by interstitial cells of Cajal (2009)

Interstitial cells of Cajal (ICCs) have been identified as pacemaker cells in the upper urinary tract and urethra, but the role of ICCs in the bladder remains to be determined. We tested the hypotheses that ICCs express cyclooxygenase (COX), and that COX products (prostaglandins), are the cause of spontaneous rhythmic contraction (SRC) of isolated strips of rabbit bladder free of urothelium. SRC was abolished by 10 microM indomethacin and ibuprofen (non-selective COX inhibitors). SRC was concentration-dependently inhibited by selective COX-1 (SC-560 and FR-122047) and COX-2 inhibitors (NS-398 and LM-1685), and by SC-51089, a selective antagonist for the PGE-2 receptor (EP) and ICI-192,605 and SQ-29,548, selective antagonists for thromboxane receptors (TP). The partial agonist/antagonist of the PGF-2alpha receptor (FP), AL-8810, inhibited SRC by approximately 50%. Maximum inhibition was approximately 90% by SC-51089, approximately 80-85% by the COX inhibitors and approximately 70% by TP receptor antagonists. In the presence of ibuprofen to abolish SRC, PGE-2, sulprostone, misoprostol, PGF-2alpha and U-46619 (thromboxane mimetic) caused rhythmic contractions that mimicked SRC. Fluorescence immunohistochemistry coupled with confocal laser scanning microscopy revealed that c-Kit and vimentin co-localized to interstitial cells surrounding detrusor smooth muscle bundles, indicating the presence of extensive ICCs in rabbit bladder. Co-localization of COX-1 and vimentin, and COX-2 and vimentin by ICCs supports the hypothesis that ICCs were the predominant cell type in rabbit bladder expressing both COX isoforms. These data together suggest that ICCs appear to be an important source of prostaglandins that likely play a role in regulation of SRC. Additional studies on prostaglandin-dependent SRC may generate opportunities for the application of novel treatments for disorders leading to overactive bladder.
Episodic Indexing: A Model of Memory for Attention Events (1999)

People often remember what they attend to in the world. Such memory can be cast as a kind of mental catalog or index of attended objects. To investigate how such an index is acquired and used, protocol data were collected from a programmer who scrolled to off‐screen objects from time to time as she worked. These protocol data were modeled using Soar, which constrains how the index is constructed. In the model, an index entry is an episodic trace encoded during attention. The trace associates the attention event with a time symbol denoting the event's occurrence. Later, the model can ask itself whether it saw that object by calling to mind an image of the attention event. If this image retrieves a time symbol, then the model infers that the object exists and can reason about bringing the object back into view. Episodic indexing is a theory of these encoding and retrieval processes. It posits that information about attention events is encoded automatically, but that retrieval requires effort and knowledge. Episodic indexing is congruent with a range of results on episodic and temporal codes and recognition and recall processes. It incorporates source monitoring (Johnson, Hashtroudi, & Lindsay, 1993) and is a simple and pervasive form of long‐term working memory (Ericsson & Kintsch, 1995).
Sound Classification and Similarity Tools (2002)

The MPEG standards are an evolving set of standards for video and audio compression. MPEG 7 technology covers the most recent developments in multimedia search and retreival, designed to standardise the description of multimedia content supporting a wide range of applications including DVD, CD and HDTV.
 Multimedia content description, search and retrieval is a rapidly expanding research area due to the increasing amount of audiovisual (AV) data available. The wealth of practical applications available and currently under development (for example, large scale multimedia search engines and AV broadcast servers) has lead to the development of processing tools to create the description of AV material or to support the identification or retrieval of AV documents. Written by experts in the field, this book has been designed as a unique tutorial in the new MPEG 7 standard covering content creation, content distribution and content consumption. At present there are no books documenting the available technologies in such a comprehensive way.
 * Presents a comprehensive overview of the principles and concepts involved in the complete range of Audio Visual material indexing, metadata description, information retrieval and browsing
 * Details the major processing tools used for indexing and retrieval of images and video sequences
 * Individual chapters, written by experts who have contributed to the development of MPEG 7, provide clear explanations of the underlying tools and technologies contributing to the standard
 * Demostration software offering step-by-step guidance to the multi-media system components and eXperimentation model (XM) MPEG reference software
 * Coincides with the release of the ISO standard in late 2001.
 A valuable reference resource for practising electronic and communications engineers designing and implementing MPEG 7 compliant systems, as well as for researchers and students working with multimedia database technology.
Surgical Outcomes Using Bioabsorbable Plating Systems in Pediatric Craniofacial Surgery (1998)

The purpose of this study was to evaluate the surgical outcomes of the 1.5-mm LactoSorb plating system (Walter Lorenz Surgical, Inc., Jacksonville, FL, U.S.A.) used to stabilize the osteotomized calvarial bone in pediatric patients who have undergone craniofacial surgery. The records of 33 consecutive pediatric patients who underwent craniofacial surgery from January 1997 through December 1997 were reviewed. There were 18 male and 15 female patients, and the age ranged from 4 months to 12 years. Patients were followed-up at 1 week, 1 month, 3 months, 6 months, and 12 months after surgery. For those patients reviewed, the following information is included: age, sex, diagnosis, surgical procedures, number and size of LactoSorb plates and screws used in each patient, operative difficulty of the screws and the heat pack, and postoperative complications, including wound healing, palpability, and infection. The LactoSorb plating system was used to stabilize the osteotomized calvarial bones in 33 patients who were diagnosed with: 1) craniosynostosis, 2) hydrocephalus, 3) fibrous dysplasia, or 4) cranial deformation. Orbital rim advancement and anterior cranial vault reshaping were performed in 17 patients. Posterior cranial vault reshaping, orbital rim advancement, and anterior cranial vault reshaping were performed in eight patients. Posterior cranial vault reshaping only was performed in seven patients. Excision of fibrous dysplasia from temporal bone was performed in one patient. One patient had a postoperative wound infection, and LactoSorb plates were palpable postoperatively in four patients. The LactoSorb plating system provided adequate rigidity for stabilizing the osteotomized calvarial bone during surgery and maintained adequate rigidity after surgery during the bone healing period before absorption. This plating system showed satisfactory results in pediatric craniofacial surgery patients.
Performance Evaluation of Temperature Sensing System Based on Distributed Anti-Stokes Raman Thermometry (2010)

We have reported an improved theoretical model and algorithm for performance evaluation of distributed temperature sensing system based on Raman scattering in optical fibers which is validated by experimental result.
High gain airborne antenna for satellite communications (1991)

The performance of an airborne phased-array antenna, which was developed and evaluated onboard a commercial aircraft using the Engineering Test Satellite V (ETS-V), is reported. The system requirements and the antenna configuration that satisfies them are described. The radiation pattern, gain and axial ratio, noise temperature and ratio of gain to noise temperature, and environmental characteristics are presented. The results obtained by the flight experiments demonstrate that the performance of the antenna is the same as that on the ground, so that the antenna is suitable for installation in an aircraft for satellite communications.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Building Dynamic HTML GUIs (1999)

From the Publisher:
Leverage the convergence of ubiquitous, HTML-based Web applications with the advanced features of HTML 4.0, including Dynamic HTML, client-side scripting languages, Cascading Style Sheets, and the Document Object Model. The book shows how to provide user-friendly, efficient, well-designed user interfaces for the next generation of Web-based applications.
The Effect of Micrococcal Nuclease Digestion on Nucleosome Positioning Data (2010)

Eukaryotic genomes are packed into chromatin, whose basic repeating unit is the nucleosome. Nucleosome positioning is a widely researched area. A common experimental procedure to determine nucleosome positions involves the use of micrococcal nuclease (MNase). Here, we show that the cutting preference of MNase in combination with size selection generates a sequence-dependent bias in the resulting fragments. This strongly affects nucleosome positioning data and especially sequence-dependent models for nucleosome positioning. As a consequence we see a need to re-evaluate whether the DNA sequence is a major determinant of nucleosome positioning in vivo. More generally, our results show that data generated after MNase digestion of chromatin requires a matched control experiment in order to determine nucleosome positions.
Use of serum prolactin for monitoring the therapeutic response in ovarian malignancy (1991)

Serum prolactin level was estimated in 20 women with ovarian malignancy. High prolactin level was observed in 13 out of 20 women. However, no correlation was seen between prolactin level and the stage of the disease. Serial measurement of prolactin showed a correlation of prolactin level with tumor mass in three patients in which serial tumor mass volume measurements were available. A rise in serum prolactin level was observed in women who had recurrence of the disease. Although the current study is based on a relatively small number of patients, it may be concluded that serum prolactin level might be used as a tumor marker to monitor the therapeutic response in cases of ovarian malignancy.
The Use Of Porphyrins And Non-Ionizing Radiation For Treatment Of Cancer (1995)

Photodynamic therapy (PDT) is the treatment of malignant lesions with visible light following systemic or local administration of a photosensitizer or its precursor. Initially, hematoporphyrin derivative and a purified component called Photofrin II was used for clinical PDT. Later on interest has focused on new sensitizers with more favourable absorption as regards light transmission in tissues. Twenty years of clinical experience has revealed that PDT is best applied to early stage cancers. The present review discusses the basic components of PDT and its clinical use in treatment of cancer.
The Paramagnetic Ground State of Ruby - Revisited (2002)

Familial forms of Alzheimer's disease (AD) are caused by mutations in the presenilin genes or in the gene encoding for the amyloid precursor protein (APP). Proteolytic cleavage of APP generates the β-amyloid peptide (Aβ), which aggregates into amyloid plaques, one of the major hallmarks of AD. APP mutations within the Aβ sequence, so-called intra-Aβ mutations, cluster around position E693 of APP, which corresponds to position E22 in the Aβ sequence. One of these mutations is the Osaka mutation, E693Δ, which has unique aggregation properties with patients showing unusually low brain amyloid levels on amyloid PET scans. Despite intense research on the pathomechanisms of different intra-Aβ mutants, our knowledge is limited due to controversial findings in various studies. Here, we investigated in an ex vivo experimental system the neuro- and synaptotoxic properties of two intra-Aβ mutants with different intrinsic aggregation propensities, the Osaka mutation E22Δ and the Arctic mutation E22G, and compared them to wild-type (wt) Aβ. Experiments in hippocampal slice cultures from transgenic mice were complemented by treating wild-type slices with recombinantly produced Aβ40 or Aβ42 containing the respective intra-Aβ mutations. Our analyses revealed that wt Aβ and E22G Aβ, both recombinant and transgenic, caused a loss of dendritic spines along with an increase in tau phosphorylation and tau-dependent neurodegeneration. In all experiments, the 42-residue variants of wt and E22G Aβ showed stronger effects than the respective Aβ40 isoforms. In contrast, E22Δ Aβ neither reduced dendritic spine density nor resulted in increased tau phosphorylation or neuronal cell death in our ex vivo system. Our findings suggest that the previously reported major differences in the aggregation kinetics between E22G and E22Δ Aβ are likely reflected in different disease pathomechanisms.
The First Clinical Trial in Tohoku University Hospital after The Great East Japan Earthquake: The Heroic Efforts of My Friend, Professor Masashi Aoki (2012)

The Great East Japan Earthquake of 2011 seriously jeopardized our collaborative research with Professor Masashi Aoki (Tohoku University School of Medicine) on the development of new therapies for amyotrophic lateral sclerosis (ALS) using hepatocyte growth factor. After the earthquake struck, Professor Aoki made a tremendous contribution to saving patients' lives and to recovering from the disastrous situation. Thanks to his strong leadership and support from many reliable colleagues, we could finally start new clinical trials for ALS patients. In this article, I wish to introduce Professor Aoki's heroic efforts.
Adaptive thresholding in dynamic scene analysis for extraction of fine line (2000)

This paper presents an adaptive threshold method whereby a fine thin line of one-pixel width lines could be detected in a gray level images. The proposed method uses the percentage difference between the mean of the pixels within a window and the center pixel. The minimum threshold value however is heuristically set to 32. If the percentage difference is greater than 40% then the threshold value will be set to the difference value. This method has been applied in detecting moving objects with fine lines and the results showed that the method was able to pickup straight thin edges that belong to the moving object.