gebhart/patrepeval huggingface dataset:
Inhibition of inducible nitric oxide synthase expression by novel nonsteroidal anti‐inflammatory derivatives with gastrointestinalsparing properties (1996)

1. The effects of novel nitric oxide-releasing nonsteroidal anti-inflammatory compounds (NO-NSAIDs) on induction of nitric oxide (NO) synthase by bacterial lipopolysaccharide (LPS) were examined in a murine cultured macrophage cell line, J774. 2. LPS-induced nitrite production was markedly attenuated by the nitroxybutylester derivatives of flurbiprofen (FNBE), aspirin, ketoprofen, naproxen, diclofenac and ketorolac, with each compound reducing accumulated nitrite levels by > 40% at the maximum concentrations (100 micrograms ml-1) used. 3. Further examination revealed that nitrite production was inhibited in a concentration-dependent (1-100 micrograms ml-1) manner by FNBE which at 100 micrograms ml-1 decreased LPS-stimulated levels by 63.3 +/- 8.6% (n = 7). The parent compound flurbiprofen was relatively ineffective over the same concentration-range, inhibiting nitrite accumulation by 24 +/- 0.9% (n = 3) at the maximum concentration used (100 micrograms ml-1). 4. FNBE reduced LPS-induced nitrite production when added to cells up to 4 h after LPS. Thereafter, FNBE caused very little or no reduction in nitrite levels. Furthermore NO-NSAIDs (100 micrograms ml-1) did not inhibit the metabolism of L-[3H]-arginine to citrulline by NO synthase isolated from LPS-activated macrophages. 5. Western blot analysis demonstrated that NO synthase expression was markedly attenuated following co-incubation of J774 cell with LPS (1 microgram ml-1; 24 h) and FNBE (100 micrograms ml-1; 24 h). Thus taken together, these findings indicate that NO-NSAIDs inhibit induction of NO synthase without directly affecting enzyme activity. 6. In conclusion our results indicate that NO-NSAIDs can inhibit the inducible L-arginine-NO pathway, and are capable of suppressing NO synthesis by inhibiting expression of NO synthase. The clinical implications of these findings remain to be established.
3D chitosan–gelatin–chondroitin porous scaffold improves osteogenic differentiation of mesenchymal stem cells (2007)

A porous 3D scaffold was developed to support and enhance the differentiation process of mesenchymal stem cells (MSC) into osteoblasts in vitro. The 3D scaffold was made with chitosan, gelatin and chondroitin and it was crosslinked by EDAC. The scaffold physicochemical properties were evaluated. SEM revealed the high porosity and interconnection of pores in the scaffold; rheological measurements show that the scaffold exhibits a characteristic behavior of strong gels. The elastic modulus found in compressive tests of the crosslinked scaffold was about 50 times higher than the non-crosslinked one. After 21 days, the 3D matrix submitted to hydrolytic degradation loses above 40% of its weight. MSC were collected from rat bone marrow and seeded in chitosan–gelatin–chondroitin 3D scaffolds and in 2D culture plates as well. MSC were differentiated into osteoblasts for 21 days. Cell proliferation and alkaline phosphatase activity were followed weekly during the osteogenic process. The osteogenic differentiation of MSC was improved in 3D culture as shown by MTT assay and alkaline phosphatase activity. On the 21st day, bone markers, osteopontin and osteocalcin, were detected by the PCR analysis. This study shows that the chitosan–gelatin–chondroitin 3D structure provides a good environment for the osteogenic process and enhances cellular proliferation.
Requirements of multiregional mobile broadband satellite networks (1998)

Chiefly as a result of the phenomenal worldwide growth in the use of the Internet, a number of geostationary satellite systems have been proposed for provision of broadband multimedia-type services. The vast majority of these systems address the needs of fixed users; however, satellites can also play an important role in the deployment of mobile networks. This article describes the requirements of a multiregional network of interconnected geostationary satellites capable of providing multimedia-type services to ubiquitous and mobile users.
Document Clustering and Social Networks (2009)

Text Mining has become a specialized offshoot of Data Mining, Information Retrieval, and Natural Language Processing. One of the major tools of this area is the vector space representation of documents. On the other hand, social network analysis has found its mathematical underpinnings primarily in mathematical graph theory. A graph has a dual representation as an adjacency matrix. So-called two-mode social networks have actors of two different types, frequently individuals and organizations. The adjacency matrix for these two-mode social networks has the same structure as the so-called term-document matrices used in text mining. In the talk we discuss these connections and show how these ideas can be exploited in both fields. In particular, methods for block modeling in social network analysis can be used for document clustering.
Time–temperature equivalence in the tack and dynamic stiffness of polymer prepreg and its application to automated composites manufacturing (2013)

A recently developed peel test designed to simulate the automated tape lay-up (ATL) process was used to measure tack and dynamic stiffness of newly developed ATL prepregs. Resin was extracted from the prepreg process before impregnation of the fibres. Isothermal small amplitude frequency sweeps were carried out in shear rheology to determine time–temperature superposition parameters in the form of Williams–Landel–Ferry equation. Gel permeation chromatography and differential scanning calorimetry demonstrated that the resin was not significantly changed during the prepregging process. The WLF parameters were used to transpose isothermal tack and dynamic stiffness results with excellent agreement found. This relationship offers manufacturers using composite prepreg a method to maximise and maintain tack levels at different feed rates by appropriate changes in temperature. This is of significant importance in improving the reliability of automated composite lay-up processes such as AFP and ATL, whose feed rate must vary to accommodate lay-up operations.
High‐Frequency QRS Analysis in Patients with Acute Myocardial Infarction: A Preliminary Study (2012)

Analysis of HFQRS morphology in patients with AMI provides information about the existence and severity of myocardial ischemia. HFQRS analysis may aid in risk stratification of patients with suspected myocardial ischemia, complementarily to conventional ECG.
SNCC: A Selective Network-Coded Cooperation Scheme in Wireless Networks (2007)

Network-coded cooperation is a new communication paradigm that exploits spatial diversity by pooling distributed "communication" (relay) and also the distributed "computation" resources (coding) of different nodes in a network so as to increase wireless networks system performance. In this paper, we develop a selective network-coded cooperation (SNCC) scheme suitable for multiple unicast transmission pairs in a single-cell wireless network. The relay node performs network coding on received information from multiple sources before forwarding the network-coded data towards the corresponding destinations, which can decode their desired data from the network-coded data and the data they overhear from the other sources. The performance analysis and evaluation in terms of the single-pair outage probability and diversity-multiplexing tradeoff show that under SNCC any transmission pair achieves a full diversity order of M+1 (M is the number of available relays) while holding a better diversity-multiplexing tradeoff performance than existing cooperative cooperation schemes. Moreover, due to the mechanism that the relay adapts the data on which to perform network coding according to the observed source-to-relay channel quality, SNCC smartly avoids error propagation due to incorporating erroneous data into network-coded data, which is verified by numerical results of the single-pair outage probability.
ChemInform Abstract: Synthesis of 4,4‐Disubstituted Piperidine Analogues of (.+‐.)‐cis‐N‐(1‐ (2‐hydroxy‐2‐phenylethyl)‐3‐methyl‐4‐piperidyl)‐N‐phenylpropanamide. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Bottom-Up Fabrication of Photoluminescent Graphene Quantum Dots with Uniform Morphology (2011)

Multicolor photoluminescent graphene quantum dots (GQDs) with a uniform size of ∼60 nm diameter and 2-3 nm thickness were prepared by using unsubstituted hexa-peri-hexabenzocoronene as the carbon source. This result offers a new strategy to fabricate monodispersed GQDs with well-defined morphology.
Contraceptive Effectiveness of Two Spermicides (1999)

In Brief Objective We conducted a multinational randomized trial to determine whether a spermicidal film containing 72 mg of nonoxynol-9 per film was at least as effective in preventing pregnancy as a foaming tablet containing 100 mg of nonoxynol-9 per tablet. Methods Between September 1995 and July 1997, 765 women aged 18–35 years who had no evidence of subfecundity were randomly assigned to use one of the two spermicides as their only contraceptive method at every coital act for 28 weeks. Participants were asked to keep coital diaries throughout the study period. Pregnancy tests were performed on a scheduled basis. Each participant was followed for 28 weeks or until she stopped considering the spermicide as her primary method of contraception. Results The Kaplan-Meier estimate of the 6-month probability of pregnancy during typical use of the spermicide was 28.0% in the tablet group and 24.9% in the film group (P = .78, one-tailed test). The study had nearly 75% power to have detected a difference of seven percentage points between groups. Results were almost identical when the analysis included only months when the participants reported use of the spermicide during every coital act. Reported levels of sexual activity and compliance with use of the spermicide were high in both groups. Conclusion The contraceptive effectiveness of these two spermicidal products appeared similar. Both products were associated with a fairly high risk of pregnancy in this young, highly sexually active population. The contraceptive effectiveness of nonoxynol-9 film was similar to that of foaming tablets, and both products were associated with fairly high probability of pregnancy.
Unusual neurotoxicity of kanamycin (1967)

THE ANTIBIOTIC kanamycin sulfate, when administered parenterally, often has a toxic effect on the sensory hair cells of the organ of Corti of the inner ear. Autopsy of the temporal bone in three cases of kanamycin deafness demonstrated degeneration of these hair cells.<sup>1</sup>Studies have shown a similar propensity for the sensory hair cells of animals to degenerate, leaving relatively unscathed the nerve fibers of the eighth cranial nerve.<sup>2</sup>Kanamycin deafness is directly related to the dose administered per day<sup>3</sup>and to the age of the patient.<sup>4</sup> Less frequent neurotoxicity caused by kanamycin includes blurring of vision, paresthesia, and curare-like neuromuscular blockade. In an early series of cases in which 23 of 81 patients receiving parenterally administered kanamycin experienced tinnitus or deafness or both, an additional four patients experienced other neurotoxicity. Two suffered transient blurring of vision; another, numbness and burning pain along the posterior aspect
Appropriate Technologies for Effective Management of Industrial and Domestic Waste Waters: The Decentralised Approach (1999)

The increasing scarcity of clean water sets the need for appropriate management of available water resources. Particularly regions suffering from a lack of water urgently need integrated environmental protection and resource conservation (EP&RC) technologies in order to enable effective management of the available water resources. EP&RC-concepts focus on a minimum of consumptive use of energy, chemicals, and water and a maximum of reuse of treated wastewater and of residues produced from the pollutants present in the wastewater. Consequently, by implementing these concepts, instead of a social threat, waste(water)s like sewage and industrial effluents become an important resource for water, fertilisers, soil conditioners and to some extent also energy. In addition, a bridge is made between environmental protection and agriculture practice, stimulating (urban) agriculture in the neighbourhood of large cities. Anaerobic treatment is considered as the core technology for mineralising organic compounds in waste(water) streams. Additional technologies are required to comply with the reuse criteria. Some examples of possible EP&RC concepts, using the anaerobic treatment technology for the reclamation of domestic sewage are discussed.
Solvatochromic characterization of polymers. Effects of relative humidity (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolvatochromic characterization of polymers. Effects of relative humidityR. Andrew McGill, M. Steven Paley, and J. Milton HarrisCite this: Macromolecules 1992, 25, 12, 3015–3019Publication Date (Print):June 1, 1992Publication History Published online1 May 2002Published inissue 1 June 1992https://pubs.acs.org/doi/10.1021/ma00038a002https://doi.org/10.1021/ma00038a002research-articleACS PublicationsRequest reuse permissionsArticle Views267Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Test Data Compression Using Selective Encoding of Scan Slices (2008)

We present a selective encoding method that reduces test data volume and test application time for scan testing of intellectual property (IP) cores. This method encodes the slices of test data that are fed to the scan chains in every clock cycle. To drive <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">N</i> scan chains, we use only <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</i> tester channels, where <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</i> =lceillog <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> ( <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">N</i> +1)rceil+2 . In the best case, we can achieve compression by a factor of <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">N</i> / <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</i> using only one tester clock cycle per slice. We derive a sufficient condition on the distribution of care bits that allows us to achieve the best-case compression. We also derive a probabilistic lower bound on the compression for a given care-bit density. Unlike popular compression methods such as embedded deterministic test (EDT), the proposed approach is suitable for IP cores because it does not require structural information for fault simulation, dynamic compaction, or interleaved test generation. The on-chip decoder is small, independent of the circuit under test and the test set, and it can be shared between different circuits. We present compression results for a number of industrial circuits and compare our results to other recent compression methods targeted at IP cores.
On the determination of dynamic errors for rise time measurement with an oscilloscope (1999)

The dynamic behavior of an oscilloscope is usually described by its bandwidth, which is not sufficient for well-founded error estimation for rise time measurement. Two rules of thumb have become most common that describe (a) a relation between bandwidth and rise time of an oscilloscope and (b) an estimation of the error resulting from the rise time limitation of the oscilloscope. Although it is well understood that these rules are approximations, no information on their accuracy and extent of validity appears in the literature. In this paper, we analyze these rules of thumb with their underlying assumptions and respect a more realistic model for oscilloscope behavior. We give accurate error estimates for a selection of typical input signals, show how well the rules perform for these signals and that, although the rules provide good upper bounds for the error, they can not be reliably used for error correction.
Association of hGrb10 Genetic Variations With Type 2 Diabetes in Caucasian Subjects (2006)

TEST 02 - Elsevier's Scopus, the largest abstract and citation database of peer-reviewed literature. Search and access research from the science, technology, medicine, social sciences and arts and humanities fields.
Boron Toxicity of Chrysanthemum1 (1973)

Abstract Boron ranging from 13 to 800 ppm was applied (100 ml per 15 cm pot) to the media of the Chrysanthemum morifolium Ramat. cvs. Improved Albatross and CF No. 2 Good News. Seasonal variation was observed in injury time and foliar toxic levels. Boron toxicity symptoms were observed at foliar levels of 136 ppm in ‘Improved Albatross’ and 350 ppm in ‘CF No. 2 Good News’ 4 days after B application in an April to May experiment, while 7 to 28 days were required to produce symptoms at foliar levels of 158 ppm in ‘Improved Albatross’ and 144 ppm in ‘CF No. 2 Good News’ in a December to March experiment. Stem length and flower diameter decreased with increases in B concentration applied. Foliar B levels exceeding 100 ppm reduced growth.
Phacoemulsification, capsulorhexis, and intraocular lens power prediction accuracy (1993)

Phacoemulsification with capsulorhexis reduces the surgical variability and may result in a more predictable refractive outcome. To evaluate the prediction accuracy with current IOL power prediction formulas, we reviewed a retrospective series of 628 phacoemulsification cases, including 148 short (< 22 mm) and 80 long (> 25 mm) eyes. Using the Binkhorst II formula and the manufacturer's recommended anterior chamber depth (ACD) values, the mean absolute refractive prediction error was 0.56 diopters (D). This error could be reduced to 0.51 D by retrospectively optimizing the ACD values for each lens type. Under similar least error conditions, the mean error was 0.51 D with the SRK/T formula and 0.47 D with the Olsen formula (P < .01). The Binkhorst formula overestimated the refraction in short eyes and underestimated the refraction in long eyes. The SRK/T and the Olsen formula were unbiased with the axial length. We hypothesize that the high prediction accuracy may be partially explained by a more predictable pseudophakic ACD with the current surgical technique.
Understanding Solvation in Hydrofluoroalkanes:  Ab Initio Calculations and Chemical Force Microscopy (2007)

Understanding solvation in hydrofluoroalkane (HFA) propellants is of great importance for the development of novel pressurized metered-dose inhaler (pMDI) formulations. HFA-based pMDIs are not only the most widely used inhalation therapy devices for treating lung diseases, but they also hold promise as vehicles for the systemic delivery of biomolecules to and through the lungs. In this work we propose a combined microscopic experimental and computational approach to quantitatively relate the chemistry of moieties to their HFA-philicity. Binding energy calculations are used to determine the degree of interaction between a propellant HFA and candidate fragments. We define a new quantity, the enhancement factor E, which also takes into account fragment-fragment interactions. This quantity is expected to correlate well with the solubility and the ability of the moieties of interest to impart stability to colloidal dispersions in HFAs. We use a methyl-based (CH) segment and its fluorinated analog (CF) to test our approach. CH is an important baseline case since it represents the tails of surfactants in FDA-approved pMDIs. CF was chosen due to the improved solubility and ability of this chemistry to stabilize aqueous dispersions in HFAs. Adhesion force from Chemical Force Microscopy (CFM) is used as an experimental analog to the binding energy calculations. The force of interaction between a chemically modified AFM tip and substrate is measured in a model HFA, which is a liquid at ambient conditions. Silanes with the same chemistry as the fragments used in the ab initio calculations allow for direct comparison between the two techniques. The CFM results provide an absolute scale for HFA-philicity. Single molecule (pair) forces calculated from the CFM experiments are shown to be in very good agreement to the E determined from the ab initio calculations. The ab initio calculations and CFM are corroborated by previous experimental studies where propellants HFAs are seen to better solvate the CF functionality.
Quantitative Diagnosis of Small Approximal Caries Lesions Utilizing Wavelength-dependent Fiber-optic Transillumination (1997)

The instruments clinically available for the diagnosis of approximal caries lesions are inadequate to detect lesions early and quantitatively. The aim of this study was to investigate whether wavelength-dependent light scattering and absorption of carious tissues may be utilized for the quantitative diagnosis of these small approximal caries lesions. Seventeen extracted premolar teeth were transilluminated at an approximal surface with a glass fiber, which transported the light from a halogen light bulb. Seven approximal surfaces contained a naturally developed small white-spot lesion, and 5 surfaces a small discolored lesion. Five teeth were sound. The occlusal surface was imaged with a CCD camera. Light in the blue and red portions of the electromagnetic spectrum was selected by means of Schott glass filters. From the obtained images, average effective decadic optical thickness differences were determined. These were plotted as a function of average mineral loss assessed by means of wavelength-independent microradiography. The correlation coefficient between the average effective decadic optical thickness difference and average mineral loss was r = 0.79 (95% CI: 0.47 ... 0.93). Different sources of variation that influence the observed correlation were defined and quantified. From these measurements, the correlation coefficient between average effective decadic optical thickness difference and "true' average mineral loss was estimated to be r = 0.92 (95% CI: 0.77 ... 0.97). The results indicate that early and, in principle, also quantitative diagnosis of approximal caries lesions is feasible when wavelength-dependent light propagation through carious tissues is utilized.