gebhart/patrepeval huggingface dataset:
Abstract 3337: Preclinical activity of NVL-655 in ALK-driven cancer models beyond non-small cell lung cancer (2022)

Abstract The ALK receptor tyrosine kinase can be aberrantly activated by gene fusions, point mutations, or amplification to promote cancer. ALK fusions are detected in approximately 5% of advanced non-small cell lung cancers (NSCLC), 50% of inflammatory myofibroblastic tumors, 50% of adult and 90% of childhood anaplastic large cell lymphomas, and rare cases of cholangiocarcinomas. Over 90 fusion partners of ALK have been identified, each exerting a different influence on the biochemical properties of the fusion protein and its preclinical sensitivity to ALK inhibitors. Besides fusions, ALK point mutations and amplification account for up to 14% and 2% of sporadic neuroblastomas, respectively, with most activating mutations occurring at residues F1174, F1245, or R1275. Some activating mutations, such as those occurring at F1174 and I1171, also confer resistance to FDA-approved ALK inhibitors. Because ALK plays an oncogenic role in diverse cancer types, it is an important therapeutic target for other indications beyond NSCLC. NVL-655 is a novel, brain-penetrant ALK-selective inhibitor that exhibits preclinical activity against ALK alterations, including resistance mutations, while also sparing inhibition of TRKB. TRKB inhibition in the central nervous system has been implicated in adverse events observed with FDA-approved ALK inhibitor lorlatinib. We previously reported the preclinical activity of NVL-655 in several NSCLC models bearing ALK-fusions, including human cell lines, a human cell-line derived xenograft, and a patient-derived xenograft. Here we report a broader characterization of NVL-655 in ALK-driven cancer models beyond NSCLC, alongside other ALK inhibitors that are either FDA-approved or in development. In biochemical assays, NVL-655 showed potent inhibition (IC50 &lt; 10 nM) of ALK with mutations at residues 1151, 1174, or 1275, all of which have been identified in neuroblastoma. In cell-based assays, NVL-655 was observed to inhibit proliferation of a human anaplastic large cell lymphoma cell line harboring NPM1-ALK fusion and human neuroblastoma cell lines harboring ALK activating mutations or amplification. In conclusion, the preclinical profile of NVL-655 supports its potential to address a medical need for patients with ALK-driven disease in both NSCLC and other cancers such as anaplastic large cell lymphoma and neuroblastoma. Citation Format: Anupong Tangpeerachaikul, Ludovic Bigot, Luc Friboulet, Henry E. Pelish. Preclinical activity of NVL-655 in ALK-driven cancer models beyond non-small cell lung cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 3337.
A neural network based expert system model (2002)

The architecture of an expert system model using artificial neural networks is proposed. The proposed model effectively supports the necessary components of an expert system such as user interface facility knowledge base, inference engine, and explanation system. The expert system model (ESM) consists of several orders of simple neural networks, each realizing a simple task. These simple neural networks are organized vertically, thereby achieving a second level of parallelism. A novel way to handle both forward and backward chaining reasoning mechanisms is presented. A secondary network model monitors the reasoning patterns of the primary model.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Investigating the Impacts of Plug-in Hybrid Electric Vehicles on Distribution Congestion (2013)

Smart grids are envisioned to support large penetrations of electrical vehicles driven by economical and environmental signals. Nevertheless, distribution system operators are becoming concerned about distribution congestion that may occur in the network with multiple domestic plug-in hybrid electric vehicles (PHEVs) charging. Therefore, investigating the impacts of high PHEV penetration levels on the performance of distribution networks seems to be essential for system operators and planners. Doing so, in this paper, PHEV characteristics are precisely extracted from valid published reports and surveys. Accordingly, a comprehensive model for investigating the impacts of different PHEV penetration levels on distribution systems for a single year and upcoming years is developed. The proposed model is applied to the IEEE 34-node test feeder, and PHEV impacts on the distribution network characteristics are reported. The results show distribution congestion occurrence for more than 11% PHEV penetration level. (4 pages)
Supercritical Fluid Technology (1992)

Over the course of the last several years, essential studies have been conducted in a wide variety of areas using supercritical fluids. The continued constructive development of the science employing these fluids is dependent upon a unique bridging of scientists from many disciplines involved in this work. This text, a compilation of several of the papers presented at the ACS meeting in Atlanta in the spring of 1991, attempts to illustrate the numerous scientific endeavors that have been and continue to be pursued. Individually, these works are able to stand alone in their viability. Collectively, they demonstrate the vast interest, the overwhelming potential and the extensive growth that is available.
Plasmonic Metasurface for Directional and Frequency-Selective Thermal Emission (2015)

Incandescent sources typically emit broadband light in all directions. Most of this radiation is lost for applications in the infrared region, such as spectroscopy or compositional analysis. Here the authors control both the spatial and temporal coherence of blackbody radiation with a plasmonic metasurface that emits a narrow band of frequencies in a small solid angle. This system operates reliably at 600 \ifmmode^\circ\else\textdegree\fi{}C using CMOS-compatible materials, inviting the development of compact, efficient, and cheap infrared sources and gas detectors.
Structural and functional dissection of the cytoplasmic domain of the transmembrane adaptor protein SIT (SHP2-interacting transmembrane adaptor protein) (2001)

SIT (SHP2-interacting transmembrane adaptor protein) is a recently identified transmembrane adaptor protein, which is expressed in lymphocytes. Its structural properties, in particular the presence of five potential tyrosine phosphorylation sites, suggest involvement of SIT in TCR-mediated recruitment of SH2 domain-containing intracellular signaling molecules to the plasma membrane. Indeed, it has recently been demonstrated that SIT inducibly interacts with the SH2-containing protein tyrosine phosphatase 2 (SHP2) via an immunoreceptor tyrosine-based inhibition motif (ITIM). Moreover, SIT is capable to inhibit TCR-mediated signals proximal of activation of protein kinase C. However, inhibition of T cell activation by SIT occurs independently of SHP2 binding. The present study was performed to further characterize the molecular interaction between SIT and intracellular effector molecules and to identify the protein(s) mediating its inhibitory function. We demonstrate that SIT not only interacts with SHP2 but also with the adaptor protein Grb2 via two consensus YxN motifs. However, mutation of both Grb2-binding sites also does not influence the inhibitory function of SIT. In contrast, mutation of the tyrosine-based signaling motif Y(168) ASV completely abrogates the ability of SIT to inhibit T cell activation. Co-precipitation experiments revealed that the tyrosine kinase p50(csk) could represent the negative regulatory effector molecule that binds to this motif.
On the Provisioning of Vehicle-Based Public Sensing Services (2015)

Thanks to their abundant on-board resources, ubiquity, and mobility, smart vehicles can be considered major candidates for providing pervasive information services. With the diversity of in-vehicle sensors along with abundant storage, processing, and communication capabilities, smart vehicles can bring a wide scope of applications into action under the public sensing paradigm outstripping other candidate mobile resources such as smartphones. In this paper, we propose the vehicular public sensing (VPS) platform that aims at utilizing the abundant resources of smart vehicles for providing ubiquitous public sensing services. The VPS platform encompasses underlying components that address the recruitment, communication, sensing, reporting, and data analytics functionalities of a typical public sensing process. Taking into account different environmental and practical setups, the VPS platform provides potential adjustments and different approaches for the operation of each component. We anticipate that by engaging smart vehicles in providing ubiquitous sensing-based services, a plethora of information services and applications will be unleashed bringing a new era of service provisioning.
Effects of granulocyte colony-stimulating factor on plasma cytokine and cytokine receptor levels and on the in vivo host response to endotoxin in healthy men (1996)

We investigated the effects of granulocyte colony-stimulating factor (G-CSF) on cytokine and cytokine receptor plasma levels and on the in vivo host response to Salmonella abortus equi endotoxin in healthy males. Twenty volunteers received 0.8 ng/kg endotoxin and saline intravenously 1 week apart in randomized order. Twelve hours before both experiments, 10 of these subjects were pretreated with 300 micrograms G-CSF subcutaneously. G-CSF itself increased granulocyte and monocyte counts and the plasma levels of tumor necrosis factor-alpha (TNF-alpha), soluble TNF receptors (sTNF-R) p55, and p75 and interleukin-1 receptor antagonist (IL-1ra). G-CSF did not influence plasma IL-1 beta and IL-6 levels. In the G-CSF-pretreated subjects endotoxin-induced surges in rectal temperature and in the plasma levels of TNF-alpha plasma levels were about 50% increased, and surges in the plasma levels of both sTNF-Rs and IL-1ra were about twice as high as in the control group. Endotoxin-induced increases in IL-6, cortisol, and heart rate were not modified by G-CSF pretreatment. Endotoxin administration induced a transient 50% reduction in leukocyte counts in the G-CSF-pretreated subjects that was not seen in the control group. We conclude that a single stand dose of G-CSF increases the plasma levels of cytokines and cytokine receptors and considerably modifies the host response of healthy humans to a low dose of endotoxin.
Regulation of FSH beta messenger ribonucleic acid levels in the rat by endogenous inhibin. (1992)

This study investigated the role of endogenous inhibin in regulating FSH beta mRNA levels subsequent to the gonadotropin surge in the immature, estradiol (E2)-treated female rat. Rats which undergo FSH surges on day 29 have low to undetectable levels of FSH beta mRNA at 0900 h on day 30, whereas those treated simultaneously with E2 and progesterone (P) implants to block these surges have considerably higher levels of FSH beta mRNA. In view of the profound inhibitory effect of inhibin on FSH beta mRNA, we examined the possibility that increased inhibin secretion is responsible for the decline in FSH beta mRNA levels on the morning after the FSH surge by immunoneutralization of endogenous inhibin. Twenty-eight day-old rats which received E2 and blank (B1) or P implants were injected iv with 0.4 ml of a potent anti-rat inhibin serum (anti I alpha, prepared in sheep against rat inhibin alpha (1-26)-Tyr27 coupled to human alpha-globulins) or normal sheep serum at 1700 to 1830 h on day 29 and were killed at 0900 h on day 30. Animals which received the inhibin antiserum showed significantly (P less than 0.001) elevated serum FSH levels (22.9 +/- 1.9 ng/ml [E2 + B1] and 17.1 +/- 0.6 ng/ml [E2 + P]) compared to those which received normal serum (4.4 +/- 0.1 [E2 + B1] and 4.2 +/- 0.1 [E2 + P]). Serum LH was undetectable (less than 0.6 ng/ml) in all groups. Free glycoprotein alpha-subunit was also increased (P less than 0.001) by antiserum to inhibin in E2 + B1-treated rats but was significantly suppressed by P after injection of either normal serum or anti I alpha. Total pituitary RNA was extracted and hybridized to cDNA probes for rat FSH beta, LH beta, and the common alpha-subunit by Northern blot analysis; RNA levels were normalized with beta-actin or cyclophilin probes. As expected, in rats which received normal serum, FSH beta mRNA levels were about 4-fold higher after treatment with E2 + P implants than after treatment with E2 + B1 implants. However, injection with anti-inhibin serum resulted in a striking elevation of FSH beta mRNA levels: 13-fold in animals treated with E2 + B1 implants and 5-fold in animals treated with E2 + P implants. There were no significant differences in levels of LH beta or alpha-subunit mRNAs between rats which received anti-inhibin or normal serum although there was a 30-40% decrease in alpha mRNA after P treatment.(ABSTRACT TRUNCATED AT 400 WORDS)
Vacuum ultraviolet (VUV) surface treatment process for flip chip and 3-D interconnections (2009)

A novel surface treatment process at room temperature was developed using vacuum ultraviolet (VUV) light with a wavelength of 172 nm. There is no temperature increase, no damage by ion bombardment and no plasma charging during the process. Immersion Au plating over electroless Ni plating and electroplated or evaporated SnCu were used as bonding pad and bonding bump materials for the evaluations. Two different VUV cleaning conditions, with N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> or O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> gas in the chamber, were compared and evaluated. Cleaning times and ambient conditions have dramatic effects on the surface contact angles. The initial contact angles of DI water before VUV cleaning for both the Au blanket and SnCu were near 80deg, but VUV cleaning to cut the organic contaminants decreased the contact angles down to around 30deg and 10deg, respectively. In addition to comparing the contact angles, X-ray photoelectron spectroscopy (XPS) and atomic force microscopy (AFM) were used to study the surface elemental composition and geometry of the bump and pad surfaces before and after the VUV cleaning. The photoelectron spectra of C 1s were obtained by XPS analysis for information on the chemical species and the XPS results showed a reduction in surface carbon for both Au and SnCu after the cleaning. The evidence indicates cleavage of the carbon-carbon bonds in the organic molecules occurs during the cleaning process. The experiments show that the VUV cleaning can effectively remove the organic contaminants on the surface of the bonding pads without surface damage or charge accumulation.
Optical techniques for signal distribution in phased arrays (1984)

Possibilite d'utiliser les fibres optiques pour la distribution de signal dans les reseaux d'antennes equiphases
Handwritten gesture recognition driven by the spatial context of strokes (2005)

In this paper, we present a new approach that explicitly exploits the spatial context of strokes to drive the shape recognition. We call this recognition method "context driven recognition" (CDR). The underlying idea is that only a sub-set of all possible symbols can be recognized in a specific spatial context. The main challenge is to detect and model automatically the context areas of interest so that the recognition method can be independent of any specific information on the targeted pen-based application. The paper details the learning scheme of the CDR method and how the obtained model is used during the recognition process. The results on a real-world pen-based recognition problem show that the method can reach better performances than a classical approach by decreasing the shape recognition complexity.
Effects of Torasemide on Left Ventricular Function and Neurohumoral Factors in Patients With Chronic Heart Failure (2003)

The effect of torasemide and furosemide therapy was compared in 50 patients who had chronic heart failure and symptoms [NYHA class II-III] despite long-term therapy with both low-dose furosemide and angiotensin-converting enzyme inhibitors. In this randomized 6-month, open-label trial, baseline and follow-up echocardiograms and neurohumoral assays were obtained in 25 group F patients (continued same dose of oral furosemide at 20-40 mg/day) and in 25 group T patients (received torasemide at 4-8 mg/day in place of furosemide). At 6 months, parameters were unchanged in group F whereas the group T patients had a lower left ventricular end-diastolic diameter (p<0.005) and left ventricular mass index (p<0.005) with improved Doppler filling parameters, decreased plasma B-type natriuretic concentration (p<0.001) and increased plasma concentrations of active renin (p<0.005) and aldosterone (p<0.001). The magnitude of these changes appeared dose dependent and it is suggested these favorable effects of switching from furosemide to torasemide may be related to aldosterone receptor blockade.
Improving code-switching speech recognition with data augmentation and system combination (2019)

We focused on a study of comprehensive approaches to an improved code-switching speech recognition, using data augmentation and system combination methods. For data augmentation, we not only use speech speed perturbation based method, but we also attempt to add diversified room impulse response based reverberate noise, as well as music, babble, and white noise based additive noise. It is found we still can achieve significant performance improvement with such noise-corrupted data augmentation methods, though our SEAME code-switching data belongs to a clean corpus. In addition to data augmentation methods, we also adopt Minimum Bayesian risk-based lattice combination method to further improve our recognition results. We achieve significant word error rate (WER) reduction on lattice combination with/without recurrent neural network language model based lattice rescoring. Compared with our previous efforts [6], we achieve up to 2.29% and 5.61% absolute WER reduction on the two dev sets respectively, while 4.83% and 8.04% absolute WER reduction after system combination.
Critical periods of brain growth and cognitive function in children (2004)

There is evidence that IQ tends to be higher in those who were heavier at birth or who grew taller in childhood and adolescence. Although these findings imply that growth in both foetal and postnatal life influences cognitive performance, little is known about the relative importance of brain growth during different periods of development. We investigated the relationship between brain growth in different periods of pre- and postnatal life and cognitive function in 221 9-year-old children whose mothers had taken part in a study of nutrition in pregnancy and whose head circumference had been measured at 18 weeks gestation, birth and 9 months of age. Cognitive function of the children and their mothers was assessed with the Wechsler Abbreviated Scale of Intelligence. Full-scale IQ at age 9 years rose by 1.98 points [95% confidence interval (CI) 0.34 to 3.62] for each SD increase in head circumference at 9 months and by 2.87 points (95% CI 1.05 to 4.69) for each SD increase in head circumference at 9 years of age, after adjustment for sex, number of older siblings, maternal IQ, age, education, social class, duration of breastfeeding and history of low mood in the post-partum period. Postnatal head growth was significantly greater in children whose mothers were educated to degree level or of higher socio-economic status. There was no relation between IQ and measurements of head size at 18 weeks gestation or at birth. These results suggest that brain growth during infancy and early childhood is more important than growth during foetal life in determining cognitive function.
Organosilylmetallic compounds: their formation and reactions, and comparison with related types (1959)

The first page of this article is displayed as the abstract.
Microwave-Accelerated Solvent- and Catalyst-Free Synthesis of 4-Aminoaryl/alkyl-7-chloroquinolines and 2-Aminoaryl/alkylbenzothiazoles (2007)

An efficient synthesis of 4-aminoaryl/alkyl-7-chloroquinolines and 2-aminoaryl/alkylbenzothiazoles has been developed by microwave-accelerated regioselective aromatic nucleophilic substitution of 4,7-dichloroquinoline and 2-chlorobenzothiazole with aromatic and aliphatic amines under solvent-free conditions in the absence of any added protic or Lewis acid catalyst. Chemoselective reaction with the amino group in preference to the phenolic hydroxy group was observed. Thus, the treatment of 4,7-dichloroquinoline (1 equiv.) with a mixture of aniline (2 equiv.) and phenol (2 equiv.) afforded exclusive formation of 4-aminophenyl-7-chloroquinoline. When 4,7-dichloroquinoline (1 equiv.) was separately treated with 2-aminophenol (2 equiv.) and 4-aminophenol (2 equiv.), 4-(2'-hydroxyphenyl)-7-chloroquinoline and 4-(4'-hydroxyphenyl)-7-chloroquinoline, respectively, were formed.
Learnable visual keywords for image classification (1999)

Article Free Access Share on Learnable visual keywords for image classification Author: Joo-Hwee Lim RWCP Information-Base Functions KRDL Lab, 21 Heng Mui Kent Terrace, S(119613), Singapore RWCP Information-Base Functions KRDL Lab, 21 Heng Mui Kent Terrace, S(119613), SingaporeView Profile Authors Info & Claims DL '99: Proceedings of the fourth ACM conference on Digital librariesAugust 1999 Pages 139–145https://doi.org/10.1145/313238.313290Published:01 August 1999Publication History 13citation538DownloadsMetricsTotal Citations13Total Downloads538Last 12 Months36Last 6 weeks3 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
An analogue frequency-division approach for subharmonic generation in microwave VCOs (2002)

An effective and simple technique for frequency division is introduced to generate subharmonic signal in wireless VCO circuits, thus eliminating the need for expensive digital prescalers. In this approach, frequency division is realised by injection locking an RC oscillator (multivibrator) at microwave frequencies. This technique is compact efficient and MMIC compatible. The feasibility of this approach was demonstrated using a GaAs HBT RC oscillator driven by a HBT MMIC VCO operating at 4 GHz. The RC oscillator can be effectively injection locked without observable additive phase-noise degradation and generates a subharmonic clock signal at 250 MHz, corresponding to a division ratio (N) of 16. The division ratio can be varied by changing the frequency of the RC oscillator. Nonlinear simulation results and analysis are also presented to explain the operating mechanism.
Temperature-insensitive long-wavelength (λ ≈14 µm) Quantum Cascade lasers with low threshold (2011)

We demonstrate high-performance, long-wavelength (λ ≈14 µm) Quantum Cascade (QC) lasers based on a diagonal optical transition and a "two-phonon-continuum" depletion scheme in which the lower laser level is depopulated by resonant longitudinal optical phonon scattering followed by scattering to a lower energy level continuum. A 2.8 mm long QC laser shows a low threshold current density of 2.0 kA/cm2, a peak output power of ~336 mW, and a slope efficiency of 375 mW/A, all at 300 K, with a high characteristic temperature T0 ~310 K over a wide temperature range from 240 K to 390 K.