gebhart/patrepeval huggingface dataset:
Systemic senile amyloid in senescence-accelerated mice. A unique fibril protein demonstrated in tissues from various organs by the unlabeled immunoperoxidase method. (1983)

Tissue sections of senescence-accelerated mice (SAM) and of mice with normal aging characteristics (R series) were studied using a peroxidase-antiperoxidase (PAP) method with specific antisera against a unique amyloid fibril protein (AS/SAM) and against murine protein AA. Anti-AS/SAM antisera reacted with amyloid tissues of SAM and aged R series mice but not with normal tissues or amyloid tissues containing protein AA. Reactivity of this and serum could be abrogated by absorption with purified AS/SAM. Amyloid deposits in liver, kidney, spleen, gastrointestinal tract, lung, heart, gonads, pancreas, salivary glands, adrenal, thyroid, skin epineurium, and blood vessels were positive for AS/SAM in both the SAM and R series. Brain and bone medulla, however, were not stained. The amyloid deposited in gonads, papillary layer of dermis, and epineurium was exclusively AS/SAM. The amyloid observed in most of the P-1 series mice was AS/SAM. In the P-2 series and R series, protein AA frequently coexisted with AS/SAM as demonstrated using a double staining method. Each amyloid localized preferentially in the liver, spleen, and gastrointestinal tract.
Modeling the organization of the WUSCHEL expression domain in the shoot apical meristem (2005)

http://www.computableplant.org/ and alternatively for a direct link to the page, http://computableplant.ics.uci.edu/bti1036 can be accessed.
Differential localization of two acid proteinases in germinating barley (<i>Hordeum vulgare</i>) seed (1995)

A cathepsin D‐like aspartic proteinase (EC 3.4.23) is abundant in ungerminated barley ( Hordeum vulgare ) seed while a 30 kDa cysteine endoproteinase (EC 3.4.22) is one of the proteinases synthesized de novo in the germinating seed. In this work, the localization of these two acid proteinases was studied at both the tissue and subcellular levels by immunomicroscopy. The results confirm that they have completely different functions. The aspartic proteinase was present in the ungerminated seed and, during germination, it appeared in all the living tissues of the grain, including the shoot and root. Contrary to previous suggestions, it was not observed in the starchy endosperm. By immunoblotting, the high molecular mass form of the enzyme (32 + 16 kDa) was found in all the living tissues, whereas the low molecular mass form (29 + 11 kDa) was not present in the shoot or root, indicating that the two enzyme forms have different physiological roles. The aspartic proteinase was localized first in the scutellar protein bodies of germinating seed, and later in the vacuoles which are formed by fusion of the protein bodies. In contrast to the aspartic proteinase, the expression of the 30 kDa cysteine proteinase began during the first germination day, and it was secreted into the starchy endosperm; first from the scutellum and later from the aleurone layer. It was not found in either shoots or roots. The 30 kDa cysteine proteinase was detected in the Golgi apparatus and in the putative secretory vesicles of the scutellar epithelium. These results suggest that the aspartic proteinase functions only in the living tissues of the grain, as opposed to the 30 kDa cysteine proteinase which is apparently one of the proteases initiating the hydrolysis of storage proteins in the starchy endosperm.
Phase encoding and decoding of short pulses at 10 Gb/s using superstructured fiber Bragg gratings (2001)

A 7-chip, 160-Gchip/s phase-shift keyed code is assigned to short pulses after reflection from a superstructured fiber Bragg grating. The code is then recognized by a second grating, which is nominally identical to the encoder grating. Such an encoding/decoding action is required in code-division multiple-access systems and packet-switched networks.
A Fast Video Stitching Method for Motion-Compensated Frames in Compressed Video Streams (2006)

We propose a fast video stitching method based on global motion tracking for motion-compensated frames, which can construct high definition or panorama video from standard definition video streams. Our method consists of two stages. The first stage calculates projection matrix between stitched frames coarsely by compensating for global motion of each input video stream. Since the result of the first stage may include some matching error, fine adjustment is performed in the second stage.
Chemometric classification of some european wines using pyrolysis mass spectrometry (1995)

Abstract The application of Curie‐point pyrolysis mass spectrometry (Py/MS) to 33 certified wine samples from different regions of Spain, France and Italy is reported. The resulting mass spectra were submitted to principal component analysis, canonical variates analysis and cluster analysis producing a final dendrogram, using average linkage clustering. A good classification was achieved according to large geographical areas (country of origin), while no correlation was found to grape species or to local areas of cultivation. The same data were submitted to artificial neural networks analysis using the back‐propagation algorithm and dividing the data into a training and a test data set. More than 90% of the test wine samples were correctly identified according to their country of origin after training of the artificial neural network. Again no correlation was found between pyrolysis mass spectra and grape species or area of cultivation. Nevertheless, the technique could be applied to rapid screenings of wine samples for the tentative identification of country of origin. In combination with other techniques (IR‐MS, NMR) it can give complementary information about the samples and their regions of origin.
VIRUS: a massively replicated 33k fiber integral field spectrograph for the upgraded Hobby-Eberly Telescope (2010)

The Visible Integral-field Replicable Unit Spectrograph (VIRUS) consists of a baseline build of 150 identical spectrographs (arrayed as 75 units, each with a pair of spectrographs) fed by 33,600 fibers, each 1.5 arcsec diameter, deployed over the 22 arcminute field of the upgraded 10 m Hobby-Eberly Telescope (HET). The goal is to deploy 96 units. VIRUS has a fixed bandpass of 350-550 nm and resolving power R~700. VIRUS is the first example of industrial-scale replication applied to optical astronomy and is capable of spectral surveys of large areas of sky. The method of industrial replication, in which a relatively simple, inexpensive, unit spectrograph is copied in large numbers, offers significant savings of engineering effort, cost, and schedule when compared to traditional instruments. The main motivator for VIRUS is to map the evolution of dark energy for the Hobby-Eberly Telescope Dark Energy Experiment (HETDEX+) using 0.8M Lyman-α emitting galaxies as tracers. The full VIRUS array is due to be deployed in late 2011 and will provide a powerful new facility instrument for the HET, well suited to the survey niche of the telescope. VIRUS and HET will open up wide field surveys of the emission-line universe for the first time. We present the design, cost, and current status of VIRUS as it enters production, and review performance results from the VIRUS prototype. We also present lessons learned from our experience designing for volume production and look forward to the application of the VIRUS concept on future extremely large telescopes (ELTs).
A noncontacting technique for measuring surface tension of liquids (1992)

We have developed a novel instrument for measuring the surface tension of liquids. It utilizes ultrasonic and optical methods to excite and detect a capillary wave packet. A focused ultrasonic transducer is used to generate a mound on the surface of a liquid. Capillary waves propagate radially outward from the mound, and a noncontacting confocal optical microscope measures the amplitude of the wave packet at any distance away from the excitation point. We invert the measured wave amplitude to obtain the dispersion relation of the capillary waves and hence the surface tension.
Spontaneous uterine rupture during a second trimester pregnancy with a history of laparoscopic myomectomy (2009)

Uterine rupture is one of the most feared obstetric complications, carrying an increased risk of maternal and perinatal morbidity and mortality. Here, we present a case of spontaneous uterine rupture during the first half of pregnancy. The patient did not report any recent trauma, however she had a history of laparoscopic myomectomy conducted three years earlier. The uterine rupture was 6-7 cm in length, located at the fundal level and was thought to originate from the previous myomectomy scar. In this report, we discuss the importance of choosing the right surgical technique and suturing method in patients undergoing myomectomy who desire to conceive in the future, and how obscure the findings of uterine rupture during pregnancy can be.
Enzyme-linked immunosorbent assay for the detection of Cryptosporidium parvum IgG in the serum of cats. (1997)

The objective was to develop an enzyme-linked immunosorbent assay (ELISA) for the detection of Cryptosporidium parvum IgG in the serum of cats. The ELISA was an indirect ELISA using soluble C. parvum oocyst antigens and a peroxidase-labeled anti-feline IgG secondary antibody. Sera from cats with Toxocara felis, Giardia spp., Aelurostrongylus abstrusus, Isospora felis, Isospora rivolta, Toxoplasma gondii, or Taenia spp. infections were assayed in specificity studies. Following optimization, the ELISA and fecal examination for oocysts were performed on samples from 170 client-owned or humane society source cats and 1 cat inoculated orally with C. parvum oocysts. Cryptosporidium parvum oocysts were detected in feces (4/170; 2.4%), and C. parvum IgG was detected in serum (26/170; 15.3%) from naturally exposed cats. The seroprevalence data suggest that some cats in the geographical area studied were exposed to C. parvum, but persistent oocyst shedding was less common. The ELISA is not useful for predicting oocyst shedding in individual cats.
RETRACTED: β-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates β-adrenoceptor switching from G <sub>s</sub> to G <sub>i</sub> (2003)

Phosphorylation of the beta(2) adrenoreceptor (beta(2)AR) by cAMP-activated protein kinase A (PKA) switches its predominant coupling from stimulatory guanine nucleotide regulatory protein (G(s)) to inhibitory guanine nucleotide regulatory protein (G(i)). beta-Arrestins recruit the cAMP-degrading PDE4 phosphodiesterases to the beta(2)AR, thus controlling PKA activity at the membrane. Here we investigate a role for PDE4 recruitment in regulating G protein switching by the beta(2)AR. In human embryonic kidney 293 cells overexpressing a recombinant beta(2)AR, stimulation with isoprenaline recruits beta-arrestins 1 and 2 as well as both PDE4D3 and PDE4D5 to the receptor and stimulates receptor phosphorylation by PKA. The PKA phosphorylation status of the beta(2)AR is enhanced markedly when cells are treated with the selective PDE4-inhibitor rolipram or when they are transfected with a catalytically inactive PDE4D mutant (PDE4D5-D556A) that competitively inhibits isoprenaline-stimulated recruitment of native PDE4 to the beta(2)AR. Rolipram and PDE4D5-D556A also enhance beta(2)AR-mediated activation of extracellular signal-regulated kinases ERK12. This is consistent with a switch in coupling of the receptor from G(s) to G(i), because the ERK12 activation is sensitive to both inhibitors of PKA (H89) and G(i) (pertussis toxin). In cardiac myocytes, the beta(2)AR also switches from G(s) to G(i) coupling. Treating primary cardiac myocytes with isoprenaline induces recruitment of PDE4D3 and PDE4D5 to membranes and activates ERK12. Rolipram robustly enhances this activation in a manner sensitive to both pertussis toxin and H89. Adenovirus-mediated expression of PDE4D5-D556A also potentiates ERK12 activation. Thus, receptor-stimulated beta-arrestin-mediated recruitment of PDE4 plays a central role in the regulation of G protein switching by the beta(2)AR in a physiological system, the cardiac myocyte.
Conditioned disjunction as a primitive connective for the propositional calculus (1948)

Focusing on parental communication is a promising way to extend the reach of HIV-related interventions and prevention programs to underserved adolescents and their families in the US. One highly relevant population in need of services is Black males who constitute more than one-third of all new HIV infection cases in the US. We sought to determine whether the family context (i.e., parent support, parent relationships) impacted HIV testing over time. For this study, we used the first and third waves of the Add Health restricted dataset from the National Longitudinal Study of Adolescent Health of Black males (average age 16.1 years). Descriptive statistics found that over 75% of the sample had never been tested for HIV/AIDS, while only 58% reported using a condom. Bivariate regression analysis followed by multinomial analysis was conducted to identify the factors that were associated with the likelihood of one-time or continued HIV/AIDS testing. Major study findings indicate that Black males, who reported positive parent support and/or had visited the doctor, were more likely to get tested for HIV/AIDS. Males who had parents or peers that possessed negative attitudes about sex were less likely to get tested for HIV. The findings of this study suggest several implications for prevention and intervention aimed at optimal ways to increase HIV testing among Black males warranting further investigation.
The possible protective effect of bee propolis on experimentally mediated cisplatin reproductive toxicity (2013)

Background Cisplatin (CIS) is one of the widely used anticancer drugs. Despite its high efficiency in the treatment of testicular cancer, CIS has severe adverse effects on spermatogenesis and may even lead to infertility. Propolis is a honeybee product. It has free-radical scavenging activity. Aim To evaluate the possible protective effect of bee propolis on CIS-induced testicular damage in adult male albino rats using histological, immunohistochemical, and morphometric studies. Materials and methods Twenty-four adult male albino rats were divided into four groups, each group including six rats: control, propolis (100 mg/kg, orally daily for 7 days), CIS (10 mg/kg by a single intraperitoneal injection and left for 5 days without treatment), and combined therapy (propolis 7 days before CIS injection and continued for 5 days after). Testicular weights were measured. Histological (using H&E and Masson’s trichrome stains) and immunohistochemical [using nuclear factor-κB (NF-κB)/p65 and claudin 11] studies were carried out. Morphometric measurements of seminiferous tubule diameter, area% of collagen fibers, and claudin 11, in addition to the optical density of NF-κB/p65, were carried out, followed by statistical analysis. Results Testicular weight decreased significantly in the CIS group. CIS induced distorted seminiferous tubules, cellular disorganization, wide separation of intertubular space, cytoplasmic vacuolation, and pyknotic nuclei. Increased area% of collagen fibers, increased optical density of NF-κB/p65 immunoreactivity, and decreased area% of claudin 11 immunoexpression were found in the spermatogenic cells. The combined therapy group showed a significant reduction in histological, immunohistochemical, and morphometric changes. Conclusions A significant role of NF-κB activation was found in CIS-induced testicular damage. Blockade of NF-κB activation by propolis could be an effective strategy for protection from CIS-induced testicular damage, provided it is administered orally early enough before the administration of CIS. It also prevented the disruption of tight junction protein, claudin 11; thus, it could preserve blood–testis barrier function.
IMPLICIT SHAPE MODELS FOR OBJECT DETECTION IN 3D POINT CLOUDS (2012)

Abstract. We present a method for automatic object localization and recognition in 3D point clouds representing outdoor urban scenes. The method is based on the implicit shape models (ISM) framework, which recognizes objects by voting for their center locations. It requires only few training examples per class, which is an important property for practical use. We also introduce and evaluate an improved version of the spin image descriptor, more robust to point density variation and uncertainty in normal direction estimation. Our experiments reveal a significant impact of these modifications on the recognition performance. We compare our results against the state-of-the-art method and get significant improvement in both precision and recall on the Ohio dataset, consisting of combined aerial and terrestrial LiDAR scans of 150,000 m2 of urban area in total.
Fabrication of Cellular Multilayers with Nanometer‐Sized Extracellular Matrix Films (2007)

Layer it on: Cellular multilayers were fabricated by preparing nanometer-sized extracellular matrix (ECM) films (6-nm thick) with fibronectin (FN) and gelatin on the surface of each cell layer. The four-layer cellular architecture was well organized and self-standing. Xenogenic human bilayer architectures similar to blood vessels were prepared by fabrication of the nanofilms on cell surfaces.
Low-pressure gas breakdown in uniform dc electric field (2000)

This paper studies in experiment and theory the breakdown of argon, nitrogen, air and oxygen in a uniform dc electric field at different discharge gaps L, discharge tube radii R and cathode materials. At arbitrary geometric dimensions of the cylindrical discharge vessel and cathode materials the ratio of the breakdown electric field value to the gas pressure p at the minimum of the breakdown curves is shown to remain constant, (Edc/p)min≈constant. A modified breakdown law for the low-pressure dc discharge Udc = f(pL,L/R) is obtained. That is, the breakdown voltage Udc is shown to depend not only on the product pL, but also on the ratio L/R. A method is presented enabling one to predict a dc breakdown curve in the cylindrical discharge vessel possessing arbitrary L and R values from the measured data on the dc breakdown.
Modern Uses of Magnetic Resonance Spectroscopy of The Brain (2004)

Dr. York is Neuroradiology Fellow and Dr. Mukundan is Assistant Professor of Radiology, Division of Neuroradiology, Department of Radiology, Duke University Medical Center, DUMC Box 3808, Durham, NC 27710; E-mail: [email protected]. The authors have disclosed that they have no significant relationships with or financial interests in any commercial organizations pertaining to this educational activity.
Enzyme Thermistor Assay of Cholesterol, Glucose, Lactose and Uric Acid in Standard Solutions as Well as In Biological Samples (1976)

Abstract A special enzyme thermistor device with a probe and a reference thermistor is described. Linear relationships between the temperature changes, At, measured with this device and the concentration of substrates applied were obtained. The substrates tested were cholesterol, glucose, lactose and uric acid in standard solutions as well as in biological samples.
Assessing direct analysis in real-time-mass spectrometry (DART-MS) for the rapid identification of additives in food packaging (2009)

The ambient ionization technique direct analysis in real time (DART) was characterized and evaluated for the screening of food packaging for the presence of packaging additives using a benchtop mass spectrometer (MS). Approximate optimum conditions were determined for 13 common food-packaging additives, including plasticizers, anti-oxidants, colorants, grease-proofers, and ultraviolet light stabilizers. Method sensitivity and linearity were evaluated using solutions and characterized polymer samples. Additionally, the response of a model additive (di-ethyl-hexyl-phthalate) was examined across a range of sample positions, DART, and MS conditions (temperature, voltage and helium flow). Under optimal conditions, molecular ion (M+H+) was the major ion for most additives. Additive responses were highly sensitive to sample and DART source orientation, as well as to DART flow rates, temperatures, and MS inlet voltages, respectively. DART-MS response was neither consistently linear nor quantitative in this setting, and sensitivity varied by additive. All additives studied were rapidly identified in multiple food-packaging materials by DART-MS/MS, suggesting this technique can be used to screen food packaging rapidly. However, method sensitivity and quantitation requires further study and improvement.
Synthesis of β-Mono-, Tetra-, and Octasubstituted Sterically Bulky Porphyrins via Suzuki Cross Coupling (1996)

beta-Mono-, tetra-, and octasubstituted tetramesitylporphyrins were prepared in good yields by Suzuki cross-coupling reactions of beta-bromotetramesitylporphyrins with aryl- and alkylboronic acids.
Performance and Durability of High Temperature Foil Air Bearings for Oil-Free Turbomachinery (2000)

The performance and durability of advanced, high temperature foil air bearings are evaluated under a wide range (10 to 50 kPa) of loads at temperatures from 25° to 650 °C. The bearings are made from uncoated nickel based superalloy foils. The foil surface experiences sliding contact with the shaft during initial start/stop operation. To reduce friction and wear, the solid lubricant coating, PS304, is applied to the shaft by plasma spraying. PS304 is a NiCr based Cr2O3 coating with silver and barium fluoride/calcium fluoride solid lubricant additions. The results show that the bearings provide lives well in excess of 30,000 cycles under all of the conditions tested. Several bearings exhibited lives in excess of 100,000 cycles. Wear is a linear function of the bearing load. The excellent performance measured in this study suggests that these bearings and the PS304 coating are well suited for advanced high temperature, oil-free turbomachinery applications.
The role of cytokines in malaria infection. (1990)

We have tested the prophylactic effect of Escherichia coli-derived recombinant human interferon gamma (rHuIFN-(gamma] against sporozoite- or trophozoite-induced Plasmodium cynomolgi B malaria infection in rhesus monkeys. Data show that treatment with only five doses of rHuIFN-(gamma) (0.1 mg/kg body weight) given on days -2, 0, and +2 after infection protected the monkeys against sporozoite-induced P. cynomolgi infection. Animals initially protected by rHuIFN-(gamma) treatment remained susceptible to reinfection. No inhibitory effect of rHuIFN-(gamma) was seen against trophozoite-induced infection. We have also tested the effect of recombinant human tumour necrosis factor (rHuTNF) in rhesus monkeys. No significant activity of TNF was seen against trophozoite-induced P. cynomolgi B infection. rHuIFN-(gamma) inhibited schizogony in functional human hepatocytes infected with P. falciparum sporozoites. These results suggest that the inhibitory effect of IFN is limited to the exoerythrocytic stage of parasite development. Interleukin-1 (IL-1) also inhibited hepatic development of P. falciparum sporozoites; however, IL-1 treatment was effective only when applied before sporozoite inoculation. IL-2 and TNF were effective in higher doses.