gebhart/patrepeval huggingface dataset:
Ferrofluid-Impregnated Paper Actuators (2011)

In this paper, we report on an inexpensive method of fabricating miniature magnetic actuators using ferrofluid impregnated paper. Different types of papers (including soft tissue paper, cleanroom paper, Whatman-1 filter paper, printer paper, and newspaper) were loaded with oil-based ferrofluid, microma-chined by a CO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> laser and coated with a thin layer of parylene-C. The soaking capability of the different papers was investigated, with the soft tissue paper having the highest loading capacity, being able to absorb ferrofluid by as much as six times its original weight. Cantilever actuators fabricated from cleanroom and filter papers were able to generate the largest force (>; 40-mg equiva lent force), whereas the soft-tissue-paper cantilevers provided the greatest deflection (40° tip angle).
Composite scaffolds: Bridging nanofiber and microsphere architectures to improve bioactivity of mechanically competent constructs (2010)

Tissue engineering often benefits from the use of composites to produce an ideal scaffold. We present the focused development of a novel structure that combines the biomimetic properties of nanofibers with the robust mechanical aspects of the sintered microsphere scaffold to produce a composite scaffold that demonstrates an ability to mimic the mechanical environment of trabecular bone while also promoting the phenotype progression of osteoblast progenitor cells. These composite nanofiber/microsphere scaffolds exhibited a mechanical modulus and compressive strength similar to trabecular bone and exhibited degradation resulting in a mass loss of 30% after 24 weeks. The nanofiber portion of these scaffolds was sufficiently porous to allow cell migration throughout the fibrous portion of the scaffold and promoted phenotype progression through focal adhesion kinase-mediated activation of the transcription factor Runx2, control scaffolds not containing nanofibers did not demonstrate extensive cell migration or phenotype progression. Ultimately, the focal adhesion kinase activity on the composite nanofiber/microsphere scaffolds demonstrated causality over the production of the mature osteoblast marker, osteocalcin, and the development of a calcified matrix.
Use of strippable coatings to protect and clean optical surfaces (1987)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text John Fine and Benjamin J. Pernick, "Use of strippable coatings to protect and clean optical surfaces," Appl. Opt. 26, 3172-3172 (1987) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
11β-Hydroxysteroid Dehydrogenase Type 1 Deficiency (‘Apparent Cortisone Reductase Deficiency’) in a 6-Year-Old Boy (2003)

In the case of precocious pubarche and accelerated growth, the diagnosis of 11beta-hydroxysteroid dehydrogenase type 1 deficiency ('apparent cortisone reductase deficiency') should be considered. The diagnosis is based on determinations of urinary steroid metabolites.
The Very Low Birth Weight Transport Goes Home: Impact on the Family (1986)

Very low birth weight (VLBW) infants are known to experience more health problems after discharge from the hospital, but the effects of such problems in terms of the demand for medical care and of the effect of this on the family are only just beginning to be described. A survey of the families of 132 children who were born weighing less than 1750 g at mostly suburban hospitals and transported to a Children's Hospital, who were 1-4 years old at the time of the survey, has revealed that these children continue to experience health problems to the extent that 35% are limited in one or more activities of daily living. They also incur greater use of health care services (17% hospitalized in the prior year; 54% with a doctor's visit in the prior month). The most important predictors of high perceived impact of these problems on the family is related to the number of activities limited by health, the age of the child, and the financial resources the family could bring to coping with the child's care. These findings provide further characterization of the families which may be most vulnerable to the ongoing health problems of the VLBW infant.
Improvement of Chromatic Dispersion and Differential Group Delay Tolerance of Incoherent Multilevel Signaling with Receiver-side Digital Signal Processing (2010)

Chromatic dispersion and differential group delay tolerance of 30-Gbit/s 8DPSK and 8QAM signaling is investigated experimentally, and we show 1.7 and 1.25 times enhancement of them in 8QAM signaling by simple receiver-side digital signal processing.
Untarnished minds (2000)

One day in 1928, the French biographer André Maurois sat next to J J Thomson at dinner at Trinity College, Cambridge. 'Why', he asked Thomson, 'does England produce so many illustrious scientists?'. Thomson replied: '[It is] because we hardly teach science at all in our schools. Over here the minds that come to physics arrive in the laboratory with a freshness untarnished by any routine.'
Instrument, hardware and software simulation in a test system (2013)

This paper reviews the requirements and methods associated with executing a test program application in simulation mode. The simulation requires running the application with a subset of instrumentation or without any instrumentation and with or without the Unit Under Test (UUT). In simulation mode some of the instruments or the UUT may not exist, which requires that the simulation environment filter and mask out errors as well as be able to return different values for various application states. Additionally, the simulation environment must also accommodate various data types including scalar, arrays, strings, structures, etc. Additionally, simulation environment should not require modification of the application code, ideally the same code will run in the simulated or non-simulated environment. The solution presented by this paper details the implementation of a simulation system that is created by enhancing the application run-time engine which is part of a commercial application development software environment (ATEasy).
Development of a genus specific primer set for detection of<i>Leishmania</i>parasites by polymerase chain reaction (1996)

We have compared the sequences of a major class of kinetoplast DNA (kDNA) minicircle (pLURkE3) of Leishmania strain UR6 with other minicircle sequences from different Leishmania species. Alignment of these sequences allowed the selection of a pair of oligonucleotides suitable as primers in polymerase chain reaction (PCR) which is specific for Leishmania parasites. PCR with this genus-specific primer set is capable of detecting 1 femtogram of kDNA. These primers have been tested with kDNAs from both old world and new world Leishmania species. The results indicate that the primers may be suitable for detection of any kind of leishmaniasis.
In vitro modification of human immunodeficiency virus infection by granulocyte-macrophage colony-stimulating factor and gamma interferon. (1986)

The ability of recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF) and gamma interferon (IFN-gamma) to modify human immunodeficiency virus (HIV; also called HTLV-III/LAV) infection in the monocytic cell line U-937 was examined. When added to persistently infected cell cultures, GM-CSF at 30-300 units per ml produced maximal reductions in reverse transcriptase activity of 37-55% 10-14 days after its addition, whereas IFN-gamma produced reductions of 64-68% 10-17 days after addition. When used prior to acute HIV infection and maintained in the cell culture system, these cytokines reduced reverse transcriptase activity 90-100% and nearly eliminated viral antigen expression but did not prevent return of productive infection after their removal. These results indicate that, in a monocyte model of HIV infection, GM-CSF and IFN-gamma substantially restrict HIV expression and that these cytokines deserve further evaluation as therapeutic alternatives in HIV-related disorders.
The modern epidemiology of heart valve disease (2015)

### Learning objectives

In this review, we will discuss the current knowledge of heart valve disease (HVD) epidemiology, how it has changed over time and possible future trends. There are large differences in HVD epidemiology between high-income and low-income countries and across different forms of HVD. The majority of morbidity and mortality attributable to HVD worldwide is due to rheumatic heart disease (RHD), which is most commonly seen in low-income countries. In high-income countries, the greatest burden of HVD referred to hospital is due to calcific aortic valve disease (CAVD). Although prevalence of HVD is low compared with coronary heart disease, the requirement for long-term follow-up, and significant investigation and treatment costs, means that the impact of HVD on healthcare systems is disproportionately large. The strong association between HVD and age, combined with the rapid ageing of populations worldwide, means that HVD has been described as the ‘next cardiac epidemic’.1

### Current knowledge

Acute rheumatic fever (ARF) occurs a number of weeks after Streptococcus pyogenes (group A streptococcus) infection, usually in children. ARF leads to valve inflammation through molecular mimicry between the streptococcal M protein and cardiac proteins such as myosin and vimentin, although it is likely that other mechanisms are also involved.2 The requirements for ARF to lead to chronic RHD are not yet fully established but are likely to be related to repeated episodes of often subclinical secondary infection, leading to progressive valve fibrosis and self-sustaining valve inflammation. Those with repeated infections are more likely to progress to chronic RHD, and extended antibiotic prophylaxis is recommended for those with a …
Nanorobotic challenges in biomedical applications, design and control (2005)

Ongoing developments in molecular fabrication, computation, sensors and motors will enable the manufacturing of nanorobots - nanoscale biomolecular machine systems. The present work constitutes a novel simulation approach, intended to be a platform for the design and research of nanorobot control. The simulation approach involves a combined and multi-scale view of the scenario. Fluid dynamics numerical simulation is used to construct the nanorobotic environment, and an additional simulation models nanorobot sensing, control and behavior. We discuss some of the most promising possibilities for nanorobotics applications in biomedical problems, paying a special attention to a stenosed coronary artery case.
The PANDA-Lightweight Penetrometer for soil investigation and monitoring material compaction (1999)

R Gorves at CUST, Blaise Pascal University, Clermont-Ferrand, France, has since 1991 designed and been developing the Panda, a light-weight (20kg) hand-held dynamic cone penetrometer for testing soils and materials. This article describes the Panda and its applications. The Panda uses variable energy from a hammer blow, and can be operated by one person to test soils to 6m deep in almost any location. An accelerometer at the head of the tool measures the hammer's speed of impact, and a retractable tape measures the penetration depth. The dynamic cone resistance and current depth are then calculated from a formula, and displayed in real time on a computer screen. The Panda's many applications can be classified into: (1) monitoring the compaction of materials used in fill, in trenching works, structures, cut and cover, and ground improvement; and (2) all types of site investigation. A simple method, available in the Panda software, interprets the results from a Panda test when monitoring fill. The article presents the results of some tests using this method, together with results at several test bed sites, representing various soil types in different parts of the UK and developed by the Building Research Establishment (BRE). The Panda can also be used for ground improvement as a purely comparative tool.
The ontogenetic development of the reticulo‐endothelial system in the rainbow trout, <i>Salmo gairdneri</i> Richardson (1985)

Abstract The phagocytosis of colloidal carbon in the adults and fry of Salmo gairdneri Richardson was investigated. Adult fish accumulated trapped carbon in the spleen, kidney and heart. Fry, as early as 4 days post‐hatch, had an efficient phagocytic system, the carbon being engulfed by free macrophages which accumulated in the connective tissue, under the skin, in the gut and in the gills. By 18 days post‐hatch, the situation was similar to that found in the adult. The trapping of carbon in the gills of young fry is discussed, and it is suggested that it acts as a special mechanism to protect the thymus from undesirable, and possible tolerigizing antigen exposure before immunocompetence is attained.
Real-time vehicle detection and tracking using stereo vision and multi-view AdaBoost (2011)

We propose a multi-layer, real-time vehicle detection and tracking system using stereo vision, multi-view AdaBoost detectors, and optical flow. By adopting a ground plane estimate extracted from stereo information, we generate a sparse set of hypotheses and apply trained AdaBoost classifiers in addition to fast disparity histogramming, for Hypothesis Verification (HV) purposes. Our tracking system employs one Kalman filter per detected vehicle and motion vectors from optical flow, as a means to increase its robustness. An acceptable detection rate with few false positives is obtained at 25 fps with generic hardware.
Bayesian Optimal Interval Design: A Simple and Well-Performing Design for Phase I Oncology Trials (2016)

Despite more than two decades of publications that offer more innovative model-based designs, the classical 3 + 3 design remains the most dominant phase I trial design in practice. In this article, we introduce a new trial design, the Bayesian optimal interval (BOIN) design. The BOIN design is easy to implement in a way similar to the 3 + 3 design, but is more flexible for choosing the target toxicity rate and cohort size and yields a substantially better performance that is comparable with that of more complex model-based designs. The BOIN design contains the 3 + 3 design and the accelerated titration design as special cases, thus linking it to established phase I approaches. A numerical study shows that the BOIN design generally outperforms the 3 + 3 design and the modified toxicity probability interval (mTPI) design. The BOIN design is more likely than the 3 + 3 design to correctly select the MTD and allocate more patients to the MTD. Compared with the mTPI design, the BOIN design has a substantially lower risk of overdosing patients and generally a higher probability of correctly selecting the MTD. User-friendly software is freely available to facilitate the application of the BOIN design. Clin Cancer Res; 22(17); 4291-301. ©2016 AACR.
Synthesis of schumanniophytine and isoschumanniophytine (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of schumanniophytine and isoschumanniophytineT. Ross Kelly and Min H. KimCite this: J. Org. Chem. 1992, 57, 5, 1593–1597Publication Date (Print):February 1, 1992Publication History Published online1 May 2002Published inissue 1 February 1992https://pubs.acs.org/doi/10.1021/jo00031a049https://doi.org/10.1021/jo00031a049research-articleACS PublicationsRequest reuse permissionsArticle Views502Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
HF test current injection based self-sensing control of PMSM for low and zero speed range using Two-Degree-of-Freedom current control (2014)

This paper deals with an innovative self-sensing control scheme based on test current instead of voltage injection. Using Two-Degree-of-Freedom current control one can overcome the bandwidth limitations which made test current injection unattractive during the last 20 years. The Two-Degree-of-Freedom control scheme consists of a model based dynamic feed forward control to set the reference response and model reference tracking controllers providing disturbance rejection and the position error signals for self-sensing control. Since Two-Degree-of-Freedom control is a model based control scheme the compensation for secondary saliencies is inherently included in the pre-control. It is shown analytically that in case of test current instead of voltage injection just the precise knowledge of the current and position dependent inductance m <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">qd</sub> <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">HF</sup> is needed in case of inductance saliency based sensorless control. The effectiveness of the proposed method is proven by experimental results.
Quenching of NO2 Fluorescence (1966)

Quenching constants for NO2 fluorescence were obtained for 13 different inert gases. Quenching cross sections range from 1/25 to 1/2 of gas kinetic and increase with increasing molecular complexity, and dipole moment. No unusual resonance effect for quenching by ground-state NO2 was found. The present data are consistent with a single radiative lifetime of 4.4×10−5 sec for excited NO2. The apparent Stern—Volmer quenching ratios are shown to be functions of both the excitation and fluorescence frequency, and the fluorescence spectrum shows the corresponding red shift at high quenching pressure. This indicates that quenching is a multistep process, although qualitative considerations suggest that a large fraction of the excess internal energy of NO2* is likely to be transferred in a single effective collision.
Automatic Gain Control for Image-Intensified Camera (2004)

Stability of a nonlinear, sampled-data automatic gain control (AGC) for image-intensified cameras is described. The AGC increases the intensifier gain if the video scene is too dim and decreases the gain if the video scene is too bright. Otherwise, the AGC does not alter the gain. The gain of the system is stable, i.e., the gain does not oscillate between two values, for all possible static video scenes if the thresholds for defining both dim and bright scenes and the gain factor are chosen properly. This paper derives the regions for gain stability and provides the criteria for choosing the thresholds and the gain factor.
Introduction to Modeling and Simulation (PDF) (2006)

This subject provides an introduction to modeling and simulation (IM/S), covering continuum methods, atomistic and molecular simulation (e.g. molecular dynamics) as well as quantum mechanics. These tools play an increasingly important role in modern engineering. You will get hands-on training in both the fundamentals and applications of these methods to key engineering problems. The lectures will provide an exposure to areas of application, based on the scientific exploitation of the power of computation. We will use web based applets for simulations and thus extensive programming skills are not required.
Summary analysis of the pre-clinical and clinical results of brain tumor patients treated with pritumumab (2009)

Pritumumab is a human IgG1 kappa antibody that has been derived from a B-cell isolated from a regional draining lymph node of a patient with cervical carcinoma. Specificity analysis of the antibody with human tissues showed the antigen, altered tumor-associated vimentin, to be highly restricted to various cancers and not normal cells and tissues. In various clinical trials in Japan 249 patients with brain cancer were treated with pritumumab. The overall response rate was between 25-30% with several survivors beyond 5-years post-treatment. The patients were on a low dose regimen of 1mg given twice a week for a course of 24 weeks for a total dose of 48 mgs per course. Pritumumab appears to be a safe and effective therapy in patients with malignant gliomas.
Anticogging: Torque ripple suppression, modeling, and parameter selection (2015)

Smooth motion is critical to some robotic applications such as haptics or those requiring high precision force control. These systems are often direct-drive, so any torque ripple in the motor output must be minimal. Unfortunately, low-torque ripple motors are expensive. Low cost brushless direct current motors are becoming more prevalent, especially from the hobby remote control community. These motors often have the required high-torque density; however, they also have significant torque ripple. This paper presents a low cost method for anticogging, the compensation of cogging torque. While other methods exist to compensate for current-based torque ripple (mutual or reluctance torque), none have addressed cogging torque, except by adding expensive force sensors. This paper presents two methods that use a position sensor (already present for servo motors) to map cogging torque to rotor position. The map is played back according to position reported from the sensor to cancel the cogging torque. The design and testing of a low cost haptic arm using anticogging shows validation; however, the approach is much broader, and can be applied to any precision force application. A model of torque ripple sources are included as a function of pulse-width modulation frequency to help choose the optimal pulse-width modulation frequency to minimize torque ripple. Test results on eleven different motors show a removal of up to 88% of torque ripple with no added cost in robotic servo applications, and in some cases having better performance than motors that are over nine times as expensive.
Landmark detection for distinctive feature-based speech recognition (1994)

This work is a component of a proposed knowledge-based speech recognition system, which uses landmarks to guide the search for distinctivefeatures. In an utterance, landmarks identify localized regions where the acoustic manifestations of the linguistically motivated distinctive features are most salient. An algorithm for automatically detecting landmarks implemented by abrupt articulatory movements is described. The algorithm is a hierarchically structured algorithm rooted in linguistic and production theory. It looks for abrupt energy changes in six frequency bands and at two levels of temporal resolution. Landmarks are found based on information about which bands contain the abrupt change, the steady-state quality in the vicinity of the proposed landmark, segmental duration constraints, and an articulatory continuity requirement. Tested on a database of continuous speech recorded in a silent room by male and female speakers, the landmark detector is shown to perform well, with a 94% true detection rate and a 10% false detection rate. Most of the missed landmarks were adjacent to reduced vowels. These promising results indicate that landmarks are robustly identifiable points in the speech waveform and that a landmark detector as a front end in a speech recognition system is feasible. [Work supported by NSF.]