gebhart/patrepeval huggingface dataset:
Differentiable Rendering: A Survey (2020)

Deep neural networks (DNNs) have shown remarkable performance improvements on vision-related tasks such as object detection or image segmentation. Despite their success, they generally lack the understanding of 3D objects which form the image, as it is not always possible to collect 3D information about the scene or to easily annotate it. Differentiable rendering is a novel field which allows the gradients of 3D objects to be calculated and propagated through images. It also reduces the requirement of 3D data collection and annotation, while enabling higher success rate in various applications. This paper reviews existing literature and discusses the current state of differentiable rendering, its applications and open research problems.
A New Fast Modular Arithmetic Method in Public Key Cryptography (2006)

模块化的算术是基本操作并且在公钥秘密成员系统起一个重要作用。一个新方法和它的理论与大整数模量根据模块化的算术证实—可变模量算法被建议在介绍的纸改进模块化的算术的速度。为可变模量算法，当模 n 的模块化的计算是困难的时，它能被模 n 的计算认识到—1 并且 n- 模 n 的容易的模块化的计算的 2 在赏钱—1 并且模 n—2。结论是新方法比由与大模量计算模块化的算术操作的直接方法好。特别，什么时候模 n~1 和模的计算 n—2 是容易的，模 n 的计算是困难的，这个新方法将更快并且在模块化的算术上比另外的算法有更多的优点。最后，建议方法有效地与大整数模量基于模块化的增加和模块化的取幂在公钥密码学被使用，这被建议。
Electrophilic addition of chlorosulfonyl isocyanate to ketones. Convenient synthesis of oxazines, oxathiazines and uracils (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectrophilic addition of chlorosulfonyl isocyanate to ketones. Convenient synthesis of oxazines, oxathiazines and uracilsJerald K. Rasmussen and Alfred HassnerCite this: J. Org. Chem. 1973, 38, 11, 2114–2115Publication Date (Print):June 1, 1973Publication History Published online1 May 2002Published inissue 1 June 1973https://pubs.acs.org/doi/10.1021/jo00951a042https://doi.org/10.1021/jo00951a042research-articleACS PublicationsRequest reuse permissionsArticle Views192Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Repeated Administration of γ‐VinylGABA Reduces Rat Brain Glutamine Synthetase Activity (1995)

The glutamine cycle has been proposed as a pathway in which glutamine synthesized in glia provides substrate for synthesis of the neurotransmitters glutamate and GABA as they are lost from neurons. To test whether GABA may regulate this pathway, the effect of elevated GABA on the glial enzyme glutamine synthetase was examined in rat brain. Repeated subcutaneous injections of the antiepileptic GABA transaminase inhibitor gamma-vinylGABA at a dose of 150 mg/kg per day for 21 days reduced glutamine synthetase activity by 36% in the cortex and 22% in the cerebellum. At 30 mg/kg per day, glutamine synthetase activity was reduced by 9.5% in the cortex but unchanged in the cerebellum. The reductions were brain specific because the skeletal muscle and liver enzymes were unaffected by gamma-vinylGABA administration. Amino acid analysis of the cortex from gamma-vinylGABA-treated rats demonstrated a 270% increase in GABA levels after 150 mg/kg but no change after 30 mg/kg. GABA levels and glutamine synthetase activity were inversely correlated. The 150 mg/kg dose significantly lowered cortical glutamine and glutamate levels. The decline in brain glutamine synthetase activity with chronic gamma-vinylGABA administration developed gradually over time and may be due to the slow turnover of this enzyme in vivo.
Constructionist Design Methodology for Interactive Intelligences (2004)

We present a methodology for designing and implementing interactive intelligences. The constructionist design methodology (CDM) -- so called because it advocates modular building blocks and incorporation of prior work -- addresses factors that we see as key to future advances in AI, including support for interdisciplinary collaboration, coordination of teams, and large-scale systems integration. We test the methodology by building an interactive multifunctional system with a real-time perception- action loop. The system, whose construction relied entirely on the methodology, consists of an embodied virtual agent that can perceive both real and virtual objects in an augmented-reality room and interact with a user through coordinated gestures and speech. Wireless tracking technologies give the agent awareness of the environment and the user's speech and communicative acts. User and agent can communicate about things in the environment, their placement, and their function, as well as about more abstract topics, such as current news, through situated multimodal dialogue. The results demonstrate the CDM's strength in simplifying the modeling of complex, multifunctional systems that require architectural experimentation and exploration of unclear subsystem boundaries, undefined variables, and tangled data flow and control hierarchies.
Antisense Oligodeoxyribonucleotides Suppress Hematologic Cell Growth Through Stepwise Release of Deoxyribonucleotides (1997)

Antisense oligodeoxyribonucleotides (ODNs) are now being extensively investigated in an attempt to achieve cell growth suppression through specific targeting of genes related to cell proliferation, despite increasing evidence of non-antisense cytotoxic effects. In the context of anti-BCR/ABL antisense strategies in chronic myeloid leukemia, we have reexamined the antiproliferative effect of phosphodiester and phosphorothioate ODNs on the leukemic cell line BV173 and on CD34+ bone marrow cells in liquid culture. The 3' sequences of the ODNs determine their effect. At concentrations of 10 micromol/L (for phosphorothioate ODNs) or 25 micromol/L (for phosphodiester ODNs), all the tested ODNs exert an antiproliferative activity, except those that contain a cytosine residue at either their two most terminal 3' positions. We show that this antiproliferative effect is due to the toxicity of the d-NMPs (5' monophosphate deoxyribonucleosides), the enzymatic hydrolysis products of the ODNs in culture medium. The toxicity of the d-NMPs on hematologic cells depends on their nature (d-CMP [2'deoxycytidine 5'-monophosphate] is not cytotoxic), on their concentration (d-GMP [2'-deoxyguanosine 5'-monophosphate], TMP [thymidine 5'-monophosphate], and d-AMP [2'-deoxyadenosine 5'-monophosphate] are cytotoxic at concentrations between 5 and 10 micromol/L), and on the coincident presence of other d-NMPs in the culture medium (d-CMP neutralizes the toxicity of d-AMP, d-GMP, or TMP). The antiproliferative activity of ODNs is thus restricted to conditions where the 3' hydrolysis process by exonucleases generates significant amounts of d-NMPs with a low proportion of d-CMP. Our results reveal a novel example of a nonantisense effect of ODNs, which should be taken into account when performing any experiment using assumed antisense ODNs.
The IL-2 receptor complex: expression and function on normal and leukemic B cells. (1995)

The interleukin 2 receptor (IL-2R) is composed of at least three different chains that may be variably expressed on normal and neoplastic lymphocytes. While considerable knowledge has been gained on the expression of the IL-2R alpha chain on human leukemic cells of different origin, less is known of the beta and gamma chains. In view of the highly pleiotropic functions exerted by IL-2, the IL-2-IL-2R interactions may play an important role in various leukemias. In this review we focus on the expression and function of the IL-2R complex on human normal and leukemic B cells. Possible implications in the expansion of the neoplastic clone and in the clinical course of the disease are discussed.
Sonar Based Outdoor Vehicle Navigation And Collision Avoidance (2005)

Abstruct - Detecting unexpected obstacles and avoiding collisions is an important task for any autonomous mobile system. This paper describes an approach using a sonar system that we implemented for the autonomous land vehicle Navlab. The general hardware configuration of the system is shown, followed by a description of how the system builds a local grid map of its environment. The information collected in the map can then be used for a variety of applications in vehicle navigation like collision avoidance, feature tracking and parking. A simple algorithm was implemented that can track a static feature such as a rail, wall or an array of parked cars and use this information to drive the vehicle. Methods for filtering the raw data and generating the steering commands are discussed and the implementation for collision avoidance and its integration with other vehicle systems is described. I. INTRODUCTION The autonomous land vehicle Navlab has already successfully been driven on roads and cross country. Different sensors are used to perceive the structure of the environment and navigate the vehicle under a variety of conditions as described for example in [SI. The sensors mainly employed so far were colour video
Supraorbital and supratrochlear notches and foramina: anatomical variations and surgical relevance (1986)

The anatomy of the supraorbital and supratrochlear notches and foramina has been studied in 111 human skulls. Of 108 skulls, 49.07% had bilateral supraorbital notches, 25.93% had bilateral supraorbital foramina, and 25% had a notch on one side and a foramen on the other side. Of 101 skulls, 97.03% had bilateral supratrochlear notches, 0.99% had bilateral foramina, and 1.98% had a notch on one side and a foramen on the other side. The methods of study and clinical relevance are discussed, along with the varying nomenclature used in the literature for defining the supraorbital and supratrochlear structures. Knowledge of the anatomy of the region is important for those doing forehead and brow lift surgery in order to avoid injuring the neurovascular bundles passing through these notches and foramina.
Alteration of organized structure of biofilm formed byStaphylococcus epidermidis on soft contact lenses (2000)

The effect of a nonsteroidal antiinflammatory drug commercially available in eye drop form (sodium diclofenac) was assayed for its ability to affect biofilms formed by clinical Staphylococcus epidermidis isolates. Biofilms produced by one strain positive for a slime-associated antigen, suggested to be expressed by more virulent strains, was not affected by sodium diclofenac treatment. On the other hand, biofilm produced by the slime-positive, antigen-negative strain showed dramatic alterations already after short treatments with sodium diclofenac as reported for salicylate and other nonsteroidal drugs. Such results suggest further investigation of the possible use of sodium diclofenac drops in the treatment of ophthalmic infections in soft contact lens wearers.
Planarian Hedgehog/Patched establishes anterior–posterior polarity by regulating Wnt signaling (2009)

Despite long-standing interest, the molecular mechanisms underlying the establishment of anterior-posterior (AP) polarity remain among the unsolved mysteries in metazoans. In the planarians (a family of flatworms), canonical Wnt/beta-catenin signaling is required for posterior specification, as it is in many animals. However, the molecular mechanisms regulating the posterior-specific induction of Wnt genes according to the AP polarity have remained unclear. Here, we demonstrate that Hedgehog (Hh) signaling is responsible for the establishment of AP polarity via its regulation of the transcription of Wnt family genes during planarian regeneration. We found that RNAi gene knockdown of Dugesia japonica patched (Djptc) caused ectopic tail formation in the anterior blastema of body fragments, resulting in bipolar-tails regeneration. In contrast, RNAi of hedgehog (Djhh) and gli (Djgli) caused bipolar-heads regeneration. We show that Patched-mediated Hh signaling was crucial for posterior specification, which is established by regulating the transcription of Wnt genes via downstream Gli activity. Moreover, differentiated cells were responsible for the posterior specification of undifferentiated stem cells through Wnt/beta-catenin signaling. Surprisingly, Djhh was expressed in neural cells all along the ventral nerve cords (along the AP axis), but not in the posterior blastema of body fragments, where the expression of Wnt genes was induced for posteriorization. We therefore propose that Hh signals direct head or tail regeneration according to the AP polarity, which is established by Hh signaling activity along the body's preexisting nervous system.
Local and Distributed Effects of Apomorphine on Fronto-Temporal Function in Acute Unmedicated Schizophrenia (1996)

We used positron emission tomography (PET) to measure brain activity in healthy control subjects and unmedicated patients with schizophrenia. Subjects were scanned in the context of a combined psychological and pharmacological challenge, and we examined the effects of apomorphine, a drug acting on dopamine receptors, on brain systems engaged by a paced verbal fluency task. This factorial design enabled comparison of control subjects and schizophrenics in terms of the activations engendered by the cognitive task and the pharmacological challenge and the interaction of the two. We report a failure of cognitive task-related activation in anterior cingulate cortex and of task-related deactivation in the left superior temporal gyrus in the schizophrenic subjects. Compared with controls, the impaired cingulate activation was significantly reversed by apomorphine. Additionally, there was a trend for the abnormal fronto-temporal pattern of activation in schizophrenic subjects to be normalized by the drug. Overall, in schizophrenic subjects the effect of apomorphine, which we interpret in terms of a net dopaminergic antagonism, was to modify the brain activity, making the pattern more akin to that seen in control subjects. The results indicate both a regionally specific abnormality of brain function in schizophrenia and an abnormal pattern of fronto-temporal interactions.
<i>Arabidopsis</i> Actin Depolymerizing Factor4 Modulates the Stochastic Dynamic Behavior of Actin Filaments in the Cortical Array of Epidermal Cells  (2011)

Actin filament arrays are constantly remodeled as the needs of cells change as well as during responses to biotic and abiotic stimuli. Previous studies demonstrate that many single actin filaments in the cortical array of living Arabidopsis thaliana epidermal cells undergo stochastic dynamics, a combination of rapid growth balanced by disassembly from prolific severing activity. Filament turnover and dynamics are well understood from in vitro biochemical analyses and simple reconstituted systems. However, the identification in living cells of the molecular players involved in controlling actin dynamics awaits the use of model systems, especially ones where the power of genetics can be combined with imaging of individual actin filaments at high spatial and temporal resolution. Here, we test the hypothesis that actin depolymerizing factor (ADF)/cofilin contributes to stochastic filament severing and facilitates actin turnover. A knockout mutant for Arabidopsis ADF4 has longer hypocotyls and epidermal cells when compared with wild-type seedlings. This correlates with a change in actin filament architecture; cytoskeletal arrays in adf4 cells are significantly more bundled and less dense than in wild-type cells. Several parameters of single actin filament turnover are also altered. Notably, adf4 mutant cells have a 2.5-fold reduced severing frequency as well as significantly increased actin filament lengths and lifetimes. Thus, we provide evidence that ADF4 contributes to the stochastic dynamic turnover of actin filaments in plant cells.
Iron(III) Complexes of Tridentate 3N Ligands as Functional Models for Catechol Dioxygenases:  The Role of Ligand <i>N</i>-alkyl Substitution and Solvent on Reaction Rate and Product Selectivity (2007)

A series of iron(III) complexes of the type [Fe(L)Cl3], where L is the variously N-alkyl-substituted bis(pyrid-2-ylmethyl)amine ligand such as bis(pyrid-2-ylmethyl)amine (L1), N,N-bis(pyrid-2-ylmethyl)methylamine (L2), N,N-bis(pyrid-2-ylmethyl)-n-propylamine (L3), N,N-bis(pyrid-2-ylmethyl)-iso-butylamine (L4), N,N-bis(pyrid-2-ylmethyl)-iso-propylamine (L5), N,N-bis(pyrid-2-ylmethyl)cyclohexylamine (L6), and N,N-bis(pyrid-2-ylmethyl)-tert-butylamine (L7), have been isolated and characterized by elemental analysis and spectral and electrochemical methods. The crystal structures of the complexes [Fe(L2)Cl3] 2, [Fe(L3)Cl3] 3, and the complex-substrate adduct [Fe(L5)(TCC)(NO3)] 5a, where TCC2- is the tetrachlorocatecholate dianion, have been determined by single-crystal X-ray crystallography. The complexes [Fe(L2)Cl3] 2 and [Fe(L3)Cl3] 3 possess a distorted octahedral geometry, in which the linear tridentate 3N ligands are cis-facially coordinated to the iron(III) center, and three chloride ions occupy the remaining coordination sites. The replacement of the N-methyl group in 2 by N-n-propyl group as in 3 leads to the formation of the Fe-Npy bonds and also the Fe-Cl bonds located trans to them of different lengths. The catecholate adduct 5a also possesses a distorted octahedral geometry, in which the ligand is cis-facially coordinated to iron(III) center, TCC2- is asymmetrically chelated trans to the two pyridyl moieties of the ligand, and one of the oxygen atoms of the nitrate ion occupies the sixth coordination site. All of the present complexes have been interacted with simple and substituted catechols. The catecholate adducts [Fe(L)(DBC)Cl] and [Fe(L)(DBC)(Sol)]+, where H2DBC is 3,5-di-tert-butylcatechol and Sol=H2O/CH3CN, have been generated in situ, and their spectral and redox properties and dioxygenase activities have been studied in dimethylformamide and dichloromethane solutions. All of the complexes catalyze the cleavage of H2DBC using molecular oxygen to afford both intra- and extradiol cleavage products. The formation of extradiol cleavage products is facilitated by cis-facial coordination of the 3N ligands and availability of vacant coordination site on iron(III) center for dioxygen binding. It is remarkable that the nature of the N-alkyl substituent in 3N ligands controls the regioselectivity of cleavage, with the n-propyl, iso-butyl, iso-propyl, and cyclohexyl groups enhancing the yield of extradiol products (46-68%) in dichloromethane. The rate of oxygenation depends upon the solvent and the Lewis acidity of iron(III) center as modified by the sterically demanding N-alkyl groups-length and degree of substitution. The plot of log (kO2) versus energy of the low-energy DBC2--to-iron(III) LMCT band is linear, demonstrating the importance of the Lewis acidity of the iron(III) center in dictating the rate of the dioxygenase reaction.
Evaluation of Mesoporous TCPSi, MCM-41, SBA-15, and TUD-1 Materials as API Carriers for Oral Drug Delivery (2007)

The feasibility of four mesoporous materials composed of biocompatible Si (TCPSi) or SiO(2) (MCM-41, SBA-15, and TUD-1) were evaluated for oral drug delivery applications. The main focus was to study the effect of the materials different pore systems (unidirectional/2D/3D) and their pore diameters, pore size distributions, pore volumes on the maximal drug load capacity, and release profiles of a loaded active pharmaceutical ingredient. Ibuprofen was used as the model drug. The total pore volume of the mesoporous solid was the main factor limiting the maximum drug load capacity, with SBA-15 reaching a very high drug load of 1:1 in weight due to its high pore volume. Dissolution experiments were performed in HBSS buffers of pH 5.5, 6.8, and 7.4 to mimic the conditions in the small intestine. At pH 5.5 the dissolution rate of ibuprofen released from the mesoporous carriers was significantly faster compared with the standard bulk ibuprofen (86-63% versus 25% released at 45 min), with the fastest release observed from the 3D pore network of TUD-1 carrier. The utilization of mesoporous carriers diminished the pH dependency of ibuprofen dissolution (pK(a) = 4.42), providing an interesting prospect for the formulation of poorly soluble drug compounds.
Pulse shaping, characterization, and phase compensation system for enhanced ultrafast laser performance (2007)

A novel device designed for pulse shaping, characterization and phase compensation in ultrafast laser systems is described. The pulse shaper exhibits low transmission loss and is widely applicable to lasers with spectral bandwidth from 10 nm to over 400 nm. Pulse characterization and phase compensation is fully computer controlled in a closed loop via MIIPS method. This system is designed to enhance performance of ultrafast oscillators and ultrafast amplifiers including terawatt lasers and cryogenically cooled amplifier systems. Seed laser spectral amplitude shaping results in increased bandwidth while preserving the output power in ultrafast regenerative amplifiers. Subsequent phase compensation enables the robust delivery of output pulses within couple of percent of transform limit. Such system could find numerous applications including MPE microscopy, CARS, and more general coherent control experiments.
Fluid Modeling of the Conversion of Methane into Higher Hydrocarbons in an Atmospheric Pressure Dielectric Barrier Discharge (2011)

Abstract A one‐dimensional fluid model for a dielectric barrier discharge in methane, used as a chemical reactor for gas conversion, is developed. The model describes the gas phase chemistry governing the conversion process of methane to higher hydrocarbons. The spatially averaged densities of the various plasma species as a function of time are discussed. Besides, the conversion of methane and the yields of the reaction products as a function of the residence time in the reactor are shown and compared with experimental data. Higher hydrocarbons (C 2 H y and C 3 H y ) and hydrogen gas are typically found to be important reaction products. Furthermore, the main underlying reaction pathways are determined. magnified image