gebhart/patrepeval huggingface dataset:
Synthetic Antimalarials. Some Derivatives of 8-Aminoquinoline. II (1949)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthetic Antimalarials. Some Derivatives of 8-Aminoquinoline. IINathan L. Drake, Robert A. Hayes, John A. Garman, Robert B. Johnson, Gordon W. Kelley, Sidney. Melamed, and Richard M. PeckCite this: J. Am. Chem. Soc. 1949, 71, 2, 455–458Publication Date (Print):February 1, 1949Publication History Published online1 May 2002Published inissue 1 February 1949https://pubs.acs.org/doi/10.1021/ja01170a023https://doi.org/10.1021/ja01170a023research-articleACS PublicationsRequest reuse permissionsArticle Views372Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Luteinized unruptured follicle: morphology, endocrine function and blood flow changes during the menstrual cycle (1995)

A case of spontaneous luteinized unruptured follicle syndrome is presented with full documentation of hormonal, morphological and haemodynamic changes. Changes in uterine blood flow were also noted. Growth of the leading follicle was slow during the follicular phase of the cycle. After the luteinizing hormone (LH) surge, growth of the follicle was more rapid. Concurrently, the follicle developed internal echogenicity with ultrasonic evidence of separation of the granulosa cell layer. The follicle was no longer visible 144 and 132 h after the LH rise and peak respectively. There was no primary progesterone rise associated with either the LH rise or peak, but a secondary progesterone rise occurred 42 h after the onset of the LH surge. Peri-follicular blood flow velocity was detected for the first time on cycle day 5 and appeared to rise after the onset of the LH surge. Peri-follicular blood flow velocity appeared to reduce after the LH surge to values associated with the follicular phase. These observations are consistent with an association of a primary granulosa cell defect with luteinized unruptured follicle syndrome which would account for the initial slow follicular growth, absent primary progesterone rise and reduction in blood flow in the wall of the follicle after the LH surge.
International Clinical Practice Guidelines for the Treatment of Acute Uncomplicated Cystitis and Pyelonephritis in Women: A 2010 Update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases (2011)

A Panel of International Experts was convened by the Infectious Diseases Society of America (IDSA) in collaboration with the European Society for Microbiology and Infectious Diseases (ESCMID) to update the 1999 Uncomplicated Urinary Tract Infection Guidelines by the IDSA. Co-sponsoring organizations include the American Congress of Obstetricians and Gynecologists, American Urological Association, Association of Medical Microbiology and Infectious Diseases-Canada, and the Society for Academic Emergency Medicine. The focus of this work is treatment of women with acute uncomplicated cystitis and pyelonephritis, diagnoses limited in these guidelines to premenopausal, non-pregnant women with no known urological abnormalities or co-morbidities. The issues of in vitro resistance prevalence and the ecological adverse effects of antimicrobial therapy (collateral damage) were considered as important factors in making optimal treatment choices and thus are reflected in the rankings of recommendations.
Various Approaches to Minimise Noises in ECG Signal: A Survey (2015)

ECG signal is time varying in nature which is most common source used for the diagnosis and analysis of heart diseases present in the patient. ECG is recorded by placing electrodes at specified positions of human body. During recording, ECG is contaminated with artifacts and noises which always degrade its quality, and makes accurate and automatic interpretation more difficult. Power line interference, baseline wanders and muscle tremors are mostly noticed artifacts or noises. So for accurate delineation of characteristics points of ECG, a good quality of ECG is necessary. This paper is presenting a survey on various methods developed for de-noising, delineation of characteristics points and classification of diseases along with their respective advantages and disadvantages.
Mitigating DoS attacks in publish-subscribe IoT networks (2017)

Internet of Things (IoT) is an emerging subject which enables multiple applications and requires robust security solutions. IoT architectures contribute to critical aspects of our society like transportation, health-care, industry, telecommunications and many others. Security is difficult to be implemented in the IoT context because the embedded devices are resource constrained and deployed in uncontrolled areas, thus being targeted by various security attacks. In scenarios like smart city, IoT networks are populated by both trusted and untrusted transient devices, thus mechanisms for mitigating complex security attacks must be implemented. Embedded networks with near real-time constraints are subject to denial-of-service attacks which can easily affect the applications availability by injecting malicious packets into the network. This paper proposes a lightweight security mechanism which addresses DoS attacks in IoT publish-subscribe applications.
Brainstem Auditory-Evoked Potential Assessment of Congenital Deafness in Dalmatians: Associations With Phenotypic Markers (1992)

To screen for congenital deafness, brainstem auditory-evoked potential (BAEP) testing was performed on 1031 Dalmatians from three geographically separated areas. Phenotypic marker assessment was done to determine markers possibly associated with deafness. Markers included sex, hair coat color, pigmentation of different areas of skin (eye rims, nose, and ears), presence of a patch, spot size and marking (density of spotting), sire and dam BAEP status, and presence of iris and retinal tapetal pigmentation. Combined data from all test sites showed 8.1% bilateral deafness (N = 83 dogs) and 21.6% unilateral deafness (N = 223), or an overall 29.7% incidence of hearing disorders. Significant (P less than 0.05) associations with deafness for the data from all test sites combined were seen for patch, sire and dam BAEP, iris pigment, and retinal pigment. However, results differed for several of the significant phenotypic markers when analyses were done on the data from the individual test sites; changes from significant to not significant were found. This suggested the existence of multiple populations of deafness patterns, and reinforced the precautionary conclusion that associations of phenotypic markers with deafness are not necessarily functionally significant.
Practical Experience with Cold In-Place Asphalt Recycling and Foamed Asphalt Full Depth Reclamation (2006)

Enhanced asphalt pavement recycling and reclaiming techniques, such as Cold In-place Recycling (CIR) and Full Depth Reclamation (FDR), are increasingly important to improved life-cycle performance and cost-effective pavement rehabilitation, particularly with escalating energy and asphalt binder costs. Asphalt pavement recycling contributes to sustainable transportation infrastructure through reduced natural resources requirements (aggregates, asphalt binders, and fuels) and environmental impacts. Practical Canadian, American, and Colombian applied design, materials, and construction experience with CIR (emulsion and foamed asphalt) and FDR (foamed asphalt and lime/foamed asphalt) is used to illustrate the processing features, overall project design procedures (pavement section evaluation, reclaimed asphalt pavement properties, structural design, materials selection and mix design), construction requirements, appropriate specifications, quality control/quality assurance, and anticipated flexible pavement performance involved. The performance of quality CIR and FDR has been positive and costeffective, particularly for rutting resistance and reflective cracking mitigation. Innovations with CIR and FDR, such as improved mix design procedures, lime use (enhanced stripping resistance and strength development), laboratory characterization (moisture susceptibility, rutting resistance, resilient modulus and fatigue endurance), higher heavy traffic levels use, mechanistic pavement design parameters, including temperature relationships, incorporation in long-life asphalt pavement structures, and probabilistic life-cycle costing, are presented with implementation guidance.
Arf1p Provides an Unexpected Link between COPI Vesicles and mRNA in<i>Saccharomyces cerevisiae</i> (2004)

The small GTPase Arf1p is involved in different cellular processes that require its accumulation at specific cellular locations. The recruitment of Arf1p to distinct points of action might be achieved by association of Arf1p with different proteins. To identify new interactors of Arf1p, we performed an affinity chromatography with GTP- or GDP-bound Arf1p proteins. A new interactor of Arf1p-GTP was identified as Pab1p, which binds to the polyA-tail of mRNAs. Pab1p was found to associate with purified COPI-coated vesicles generated from Golgi membranes in vitro. The stability of the Pab1p-Arf1p complex depends on the presence of mRNA. Both symmetrically distributed mRNAs as well as the asymmetrically localized ASH1 mRNA are found in association with Arf1p. Remarkably, Arf1p and Pab1p are both required to restrict ASH1 mRNA to the bud tip. Arf1p and coatomer play an unexpected role in localizing mRNA independent and downstream of the SHE machinery. Hereby acts the SHE machinery in long-range mRNA transport, whereas COPI vesicles could act as short-range and localization vehicles. The endoplasmic reticulum (ER)-Golgi shuttle might be involved in concentrating mRNA at the ER.
The secondary structure of ribosomal ribonucleic acid in solution (1966)

The u.v.-absorption spectrum of ribosomal RNA from rabbit reticulocytes was studied as a function of temperature at different pH values. The changes in the spectrum over the range 220-320mp were interpreted on the basis ofthe assumption * Abbreviations: TYMV, turnip yellow-mosaic virus; A, G, U and C, adenine, guanine, uracil and cytosine residues respectively; oligoA etc., oligoadenylic acid etc.; polyA etc., polyadenylic acid etc., polyAU etc., copolymer of adenylic acid and uridylic acid etc.; poly(A+U) etc., complex of
SeqGL identifies context-dependent binding signals in genome-wide regulatory element maps (2014)

Genome-wide maps of transcription factor (TF) occupancy and regions of open chromatin implicitly contain DNA sequence signals for multiple factors.We present SeqGL, a novel de novo motif discovery algorithm to identify multiple TF sequence signals from ChIP-, DNase-, and ATAC-seq profiles.SeqGL trains a discriminative model using a k-mer feature representation together with group lasso regularization to extract a collection of sequence signals that distinguish peak sequences from flanking regions.Benchmarked on over 100 ChIPseq experiments, SeqGL outperformed traditional motif discovery tools in discriminative accuracy.Furthermore, SeqGL can be naturally used with multitask learning to identify genomic and cell-type context determinants of TF binding.SeqGL successfully scales to the large multiplicity of sequence signals in DNase-or ATAC-seq maps.In particular, SeqGL was able to identify a number of ChIP-seq validated sequence signals that were not found by traditional motif discovery algorithms.Thus compared to widely used motif discovery algorithms, SeqGL demonstrates both greater discriminative accuracy and higher sensitivity for detecting the DNA sequence signals underlying regulatory element maps.SeqGL is available at
The selective sigma2-ligand Lu 28-179 has potent anxiolytic-like effects in rodents. (1997)

The anxiolytic potential of the selective sigma2 ligand 1-[4-[1-(4-Fluorophenyl)-1H-indol-3-yl]-1-butyl]spiro[isobenzofuran-1(3H),4-piperidine] [corrected] (Lu 28-179) was assessed in various animal models of anxiety in rodents. Lu 28-179 facilitated the exploratory behavior of mice and rats in the black and white two-compartment box over a large dose range. In the rat, the minimal effective dose (MED) was 0.18 nmol/kg (0.1 microg/kg), and in the mouse, the MED was 0.00018 nmol/kg (0.1 ng/kg). The anxiolytic-like effect was maintained after treatment with 1 microg/kg/day for up to 14 days, and no anxiogenic-like effects were seen upon withdrawal from repeated treatment. Lu 28-179 increased the time that pairs of rats spent in active social interaction (unfamiliar high-light conditions), MED = 0.1 ng/kg. Daily treatment with Lu 28-179 (1.8 nmol/kg = 1 microg/kg/day) for up to 4 weeks increased the social interaction time significantly compared with controls, and no anxiogenic-like effects were seen upon withdrawal. Furthermore, Lu 28-179 reversed shock-induced suppression of drinking in the rat (MED = 18,000 nmol/kg = 10 mg/kg). Lu 28-179 did not inhibit footshock-induced ultrasonic vocalization in the rat or isolation-induced aggressive behavior in the mouse. Lu 28-179 was over 100 times more potent than diazepam in the rat and mouse black and white test box and the rat social interaction test, whereas the potency of Lu 28-179 was comparable to that of lorazepam in reversal of shock-induced suppression of drinking. Lu 28-179 neither induced sedation nor impaired motor coordination, even at high doses (70,000 nmol/kg = 40 mg/kg). In conclusion, Lu 28-179 exerts potent and long-lasting anxiolytic-like effects in rodents without inducing sedation and withdrawal anxiogenesis.
Development of Highly Efficient Thermally Activated Delayed Fluorescent Porphyrins and its Application to the Polymer OLEDs (2005)

Highly efficient thermally activated delayed fluorescence (TADF) was found in 6 types of Sn4+-porphyrin complexes. Photoluminescent characteristics of these complexes were studied. TADF intensity of each complex was increased with the rising of temperature, and it caused visual increase of the fluorescence. Moreover, these complexes were applied to the organic light emitting diode.
Autonomous Transport Vehicles: Where We Are and What Is Missing (2015)

In this article, we address the problem of realizing a complete efficient system for automated management of fleets of autonomous ground vehicles in industrial sites. We elicit from current industrial practice and the scientific state of the art the key challenges related to autonomous transport vehicles in industrial environments and relate them to enabling techniques in perception, task allocation, motion planning, coordination, collision prediction, and control. We propose a modular approach based on least commitment, which integrates all modules through a uniform constraint-based paradigm. We describe an instantiation of this system and present a summary of the results, showing evidence of increased flexibility at the control level to adapt to contingencies.
Synthesis of lycorines by intramolecular aryne cycloadditions (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of lycorines by intramolecular aryne cycloadditionsConcepcion Gonzalez, Dolores Perez, Enrique Guitian, and Luis CastedoCite this: J. Org. Chem. 1995, 60, 20, 6318–6326Publication Date (Print):October 1, 1995Publication History Published online1 May 2002Published inissue 1 October 1995https://doi.org/10.1021/jo00125a017RIGHTS & PERMISSIONSArticle Views604Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Get e-AlertsSupporting Info (4)»Supporting Information Supporting Information Get e-Alerts
IMPROVED BRONCHOSCOPIC GLASSES (1949)

A DESCRIPTION of these glasses first appeared in the Archives in August 1933.<sup>1</sup>An additional feature has since been added, which is of great value to the bronchoscopist. The glasses consist of an ordinary frame into which lenses may be fitted. A hole is drilled through the bridge between the lens and the ear piece on each side and a bolt is inserted which serves as a center for a thin glass disk from 7.5 to 8 cm. in diameter. The disk may be rotated and provides protection for the eyes against material coughed out of the bronchoscope, as well as unlimited clear visual fields in case the glass is soiled. If corrective lenses are necessary, particularly for presbyopia, the oculist's prescription may be divided in such a way as to give proper definition at the varying distances represented by the standard endoscopic tubes. Part of the prescription is
Studies on Condensed Triazines as Chemotherapeutic Agents, II. Synthesis of 1,2,4‐Triazino[5,6‐<i>b</i>]indoles and Related Compounds (1980)

Abstract 1,2,4‐Triazino[5,6‐ b ]indoles and their derivatives are prepared by the cyclisation of isatin 3‐thiosemicarbazone (1) followed by condensation and displacement reactions. Condensations of 3‐hydrazino‐1,2,4‐triazino[5,6‐ b ]indole (4) with ethoxymethylenemalononitrile, ethyl ethoxymethylenecyanoacetate, acetylacetone and methyl bis(methylmercapto)methylenecyanoacetate yield the corresponding 3‐pyrazolo‐1,2,4‐triazino[5,6‐b]indoles 6–9. The hydrazine 4 is further transformed into the higher heterocycles 10–12 on reaction with formic, acetic or nitrous acids.
Depression as an Antecedent of Frequency of Intravenous Drug Use in an Urban, Nontreatment Sample (1993)

The present study examined the relationship between depressive symptoms and frequency of drug use in 91 low income nontreatment intravenous drug users in Baltimore, Maryland. The majority of participants were injecting both heroin and cocaine. Scores on the depression scale at both waves were correlated with frequency of injection at wave two. Depression at wave one had a higher correlation with frequency of injections at wave two than did concurrent depression at wave two. Even after accounting for several confounds between depression and frequency of injection, depression at wave one remained highly correlated with frequency of injection at wave two.
Absence of evidence of retroviral infection in idiopathic CD4+ T-lymphocytopenia syndrome (1994)

Heredia, A.; Muller, J.; Soriano, V.; Lee, S. F.; Castro, A; Pedreira, J.; Poffemberger, K. L.; Epstein, J.; Hewlett, I. K. Author Information
Affinity liquid‐liquid extraction of lactate dehydrogenase on a large scale (1987)

Rapid liquid-liquid extraction of lactate dehydrogenase from muscle by using a low-cost aqueous bipolymer two-phase system was achieved by using a centrifugal separator. Extraction of the target enzyme into the upper phase was enhanced by including the dye Procion yellow HE-3G (bound to polyethylene glycol). The dye acted as an affinity ligand for the enzyme. The isolation of the enzyme was carried out either by using a cell extract or by homogenizing the muscle directly in the system. The latter approach reduced the preparation time with a factor of 0.25. The two methods gave, respectively, 310 and 360 kU lactate dehydrogenase/kg muscle (measured at 22 degrees C). By using a small centrifugal separator, Alfa Laval LAPX 202, 3-5 kg muscle could be processed/h in a 30-L, two-phase system.
A Full-Image Full-Resolution End-to-End-Trainable CNN Framework for Image Forgery Detection (2020)

Due to limited computational and memory resources, current deep learning models accept only rather small images in input, calling for preliminary image resizing. This is not a problem for high-level vision problems, where discriminative features are barely affected by resizing. On the contrary, in image forensics, resizing tends to destroy precious high-frequency details, impacting heavily on performance. One can avoid resizing by means of patch-wise processing, at the cost of renouncing whole-image analysis. In this work, we propose a CNN-based image forgery detection framework which makes decisions based on full-resolution information gathered from the whole image. Thanks to gradient checkpointing, the framework is trainable end-to-end with limited memory resources and weak (image-level) supervision, allowing for the joint optimization of all parameters. Experiments on widespread image forensics datasets prove the good performance of the proposed approach, which largely outperforms all baselines and all reference methods.
The Nature of Adverse Events in Hospitalized Patients (1991)

Although the prevention of many adverse events must await improvements in medical knowledge, the high proportion that are due to management errors suggests that many others are potentially preventable now. Reducing the incidence of these events will require identifying their causes and developing methods to prevent error or reduce its effects.
A Continuous Electrolytic Analyzer for Acidic or Basic Components of Process Gas Streams. (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Continuous Electrolytic Analyzer for Acidic or Basic Components of Process Gas Streams.R. L. Burnett and R. F. KlaverCite this: Anal. Chem. 1963, 35, 11, 1709–1712Publication Date (Print):October 1, 1963Publication History Published online1 May 2002Published inissue 1 October 1963https://pubs.acs.org/doi/10.1021/ac60204a050https://doi.org/10.1021/ac60204a050research-articleACS PublicationsRequest reuse permissionsArticle Views16Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts