gebhart/patrepeval huggingface dataset:
A Novel c-Jun N-terminal Kinase (JNK)-binding Protein WDR62 Is Recruited to Stress Granules and Mediates a Nonclassical JNK Activation (2009)

The c-Jun N-terminal kinase (JNK) is part of a mitogen-activated protein kinase (MAPK) signaling cascade. Scaffold proteins simultaneously associate with various components of the MAPK signaling pathway and play a role in signal transmission and regulation. Here we describe the identification of a novel scaffold JNK-binding protein, WDR62, with no sequence homology to any of the known scaffold proteins. WDR62 is a ubiquitously expressed heat-sensitive 175-kDa protein that specifically associates with JNK but not with ERK and p38. Association between WDR62 and JNKs occurs in the absence and after either transient or persistent stimuli. WDR62 potentiates JNK kinase activity; however it inhibits AP-1 transcription through recruitment of JNK to a nonnuclear compartment. HEK-293T cells transfected with WDR62 display cytoplasmic granular localization. Overexpression of stress granule (SG) resident proteins results in the recruitment of endogenous WDR62 and activated JNK to SG. In addition, cell treatment with arsenite results in recruitment of WDR62 to SG and activated JNK to processing bodies (PB). JNK inhibition results in reduced number and size of SG and reduced size of PB. Collectively, we propose that JNK and WDR62 may regulate the dynamic interplay between polysomes SG and PB, thereby mediating mRNA fate after stress.
Consequences Of Bias and Imprecision in Measurements of Glucose and Hba1c for the Diagnosis and Prognosis of Diabetes Mellitus (2005)

For clinical settings, with so clear recommendations and descriptions of risk curves as in diabetes, it is relatively easy to estimate the analytical quality specifications according to the highest level of the model hierarchy, when relevant probabilities for the events are assumed.
Fundamental hmrations of small antennas: validation of wheeler's formulas (2006)

About sixty years ago, Harold A Wheeler published a paper entitled, "Fundamental Limitations of Small Antennas." Wheeler presented formulas that related the antenna radiation Q to the physical volume of the antenna. This paper (1) briefly reviews the history of the fundamental limitations of small antennas, (2) presents Wheeler's formulas in a revised form, and (3) uses the WIPL-D computer code to validate the Wheeler formulas. The goal is to demonstrate that the Wheeler paper did, indeed, address the fundamental limitations of electrically small antennas, and that it is very useful in the understanding and quantification of these limitations
Simple Proofs of a Geometric Property of Four-Bar Linkages (2003)

(2003). Simple Proofs of a Geometric Property of Four-Bar Linkages. The American Mathematical Monthly: Vol. 110, No. 6, pp. 482-494.
Chemoenzymatic Synthesis of the Microbial Elicitor (−)-Syringolide via a Fructose 1,6-Diphosphate Aldolase-Catalyzed Condensation Reaction (2000)

Syringolide 2, an elicitor of the bacterial plant pathogen Pseudomonas syringae pv. tomato which triggers a hypersensitive defense response in resistant soybean plants, has been synthesized in five steps via a fructose 1,6-diphosphate aldolase reaction.
ATR inhibition disrupts rewired homologous recombination and fork protection pathways in PARP inhibitor-resistant BRCA-deficient cancer cells (2017)

Poly-(ADP-ribose) polymerase (PARP) inhibitors (PARPis) selectively kill BRCA1/2-deficient cells, but their efficacy in BRCA-deficient patients is limited by drug resistance. Here, we used derived cell lines and cells from patients to investigate how to overcome PARPi resistance. We found that the functions of BRCA1 in homologous recombination (HR) and replication fork protection are sequentially bypassed during the acquisition of PARPi resistance. Despite the lack of BRCA1, PARPi-resistant cells regain RAD51 loading to DNA double-stranded breaks (DSBs) and stalled replication forks, enabling two distinct mechanisms of PARPi resistance. Compared with BRCA1-proficient cells, PARPi-resistant BRCA1-deficient cells are increasingly dependent on ATR for survival. ATR inhibitors (ATRis) disrupt BRCA1-independent RAD51 loading to DSBs and stalled forks in PARPi-resistant BRCA1-deficient cells, overcoming both resistance mechanisms. In tumor cells derived from patients, ATRis also overcome the bypass of BRCA1/2 in fork protection. Thus, ATR inhibition is a unique strategy to overcome the PARPi resistance of BRCA-deficient cancers.
Home versus in-centre haemodialysis for end-stage kidney disease (2014)

Insufficient randomised data were available to determine the effects of home haemodialysis on survival, hospitalisation, and quality of life compared with in-centre haemodialysis. Given the consistently observed benefits of home haemodialysis on quality of life and survival in uncontrolled studies, and the low prevalence of home haemodialysis globally, randomised studies evaluating home haemodialysis would help inform clinical practice and policy.
Downregulation of the GnT-V gene inhibits metastasis and invasion of BGC823 gastric cancer cells (2013)

Metastatic and invasive potential is a barrier to the successful treatment of gastric cancer. N-acetylgluco-saminyltransferase V (GnT-V), a key enzyme catalyzing the formation of 1,6 N-acetylglucosamine (GlcNAc), has been demonstrated to display a distinct function in different types of tumors. The aim of this study was to investigate the role of GnT-V in the invasive potential of BGC823 human gastric cancer cells in vitro and the possible underlying mechanism. GnT-V was downregulated in BGC823 cells by oligo-siRNA transfection. Cell proliferation and invasiveness were assessed by CCK-8 assay, Tunel assay, scratch-wound assay as well as transwell assay. The products of GnT-V, β1-6 branching of asparagine-linked oligosaccharides, were determined by L-PHA lectin blot analysis. The expression of EGFRs, E-cadherin/vimentin and MMP-2/MMP-9 was analyzed both at the mRNA and protein levels. The results showed that downregulation of GnT-V decreased proliferation and the metastatic/invasive potential of BGC823 cells. The expression of EGFRs, E-cadherin/vimentin and MMP-9, molecules related to cancer metastasis and invasion in various tumors, were influenced correspondingly. These findings suggest that downregulation of GnT-V inhibited cell metastasis and invasion of BGC823 cells via EGFR signaling-initiated EMT phenotype and MMP-9 expression. These results provide a novel mechanism to explain the role of GnT-V in cell metastasis and invasion.
Extraction and purification of tumorigenic Schwann cells in vitro from neurofibromatosis type 2 tissues (2011)

Objective To establish a simple method to extract and purify tumorigenic Schwann cells (TSCs) from neurofibromatosis type 2 (NF2) tumor tissues in vitro, in order to improve the successful rate of primary culture and obtain a large number of TSCs from NF2 patients for further study. Methods Six fresh tumor tissues from patients with NF2 were obtained from 2009 to 2010 in our hospital. TSCs were extracted after collagenase digestion, followed by cell purification through rapid digestion with low trypsin concentration, differential detachment and clone screening. Morphological changes of TSCs were observed under inverted microscope and cultured TSCs were identified immunocytochemically by S ⁃ 100 protein staining. Results TSCs were successfully cultured from 3 NF2 specimens. A large number of bipolar spindle or triangular⁃shaped cells could be seen on the third day of primary culture and 4 to 5 clones were formed after the third passage in each successfully cultured specimen. Purified TSCs expressed S ⁃ 100 protein detected by immunocytochemistry with the rate of positive cells of above 95%, and their cell activity was fine and were able to be passaged stably in the subculture. Conclusion It is a successful culture method to extract and purify TSCs, combining primary culture with rapid trypsin digestion with low concentration and differential detachment. After clone screening, the purified and energetic TSCs can be obtained and applied to clinical study for NF2 pathogenesis and treatment. Fibroblasts (FBs) can be removed effectively as well. DOI：10.3969/j.issn.1672-6731.2011.01.017
Predictive mobility support for QoS provisioning in mobile wireless environments (2001)

With the proliferation of wireless network technologies, mobile users are expected to demand the same quality of service (QoS) available to fixed users. This paper presents a predictive and adaptive scheme to support timed-QoS guarantees in pico- and micro-cellular environments. The proposed scheme integrates the mobility model into the service model to achieve efficient network resource utilization and avoid severe network congestion. The mobility model uses a probabilistic approach to determine the most likely cluster to be visited by the mobile unit. The admission control is invoked when a new call arrives or an existing call performs a handoff to verify the feasibility of supporting the call. The performance of the proposed schemes is compared to the shadow cluster scheme. The performance of the proposed scheme under different traffic patterns is also presented.
Preparation of scale inhibitor by using the waste of refined 2‐acrylamido‐2‐methylpropane sulfonic acid (2016)

Acrylic acid‐2‐acrylamido‐2‐methylpropane sulfonic acid (AA‐AMPS) is a kind of copolymer with good scale and corrosion inhibition performance. Refining of AMPS produces refined residue, which belongs to hazardous waste and must be properly treated and disposed. In this work, the refined residue was reused as the raw material to synthesize scale inhibition copolymer with the addition of AA. The chemical construction and thermal properties of copolymers were confirmed by NMR, FTIR, and thermogravimetry analysis (TGA). To achieve a comprehensive and systematic understanding of copolymers, the inhibition behavior of CaCO 3 , Ca 3 (PO 4 ) 2 , and CaSO 4 were examined through static scale inhibition tests. The capability of ferric oxide dispersion was also determined. The results of structural analysis were consistent with the expected structures. Static experiments were observed that scale inhibition of Ca 3 (PO 4 ) 2 and CaSO 4 was excellent and the scale inhibition rate was close to 100% when the concentration of AA‐AMPS was 30 mg L −1 . It was noticed that the performance of copolymers synthesized with AMPS residue appeared nearly no different than when AA‐AMPS was synthesized with normal materials. The results show that the refined AMPS residue could be reused as raw material to prepare scale inhibitor copolymer. Significance : Refined residue of AMPS was used to synthesize scale inhibition copolymer in this work. It would bring serious damage to society and environment if the hazardous waste refined residue cannot be properly treated and disposed. This study shows that the reuse of refined residue could achieve the goals of making use of waste and save the resources. This reuse technology develops a new way to reuse the hazardous waste and it would provide both economical and environmental benefits. © 2016 American Institute of Chemical Engineers Environ Prog, 35: 833–839, 2016
The nonuniform discrete Fourier transform and its applications in filter design. II. 2-D (1996)

For part I see ibid., vol. 43, no. 6, p. 422-33 (1996). The concept of the nonuniform discrete Fourier transform (NDFT) is extended to two dimensions to provide a basic framework for nonuniform sampling of 2-D sequences in the frequency domain. The 2-D NDFT of a sequence of size N/sub 1//spl times/N/sub 2/ is defined as samples of its 2-D z-transform evaluated at N/sub 1/N/sub 2/ distinct points located in the 4-D (z/sub 1/, z/sub 2/) space. These points are chosen appropriately so that the inverse transform exists. We discuss two special cases in which the choice of the sampling points is constrained so that the 2-D NDFT matrix is guaranteed to be nonsingular, and the number of operations required for computing its inverse is reduced, The 2-D NDFT is applied to nonuniform frequency sampling design of 2-D finite-impulse-response (FIR) filters. Nonseparable filters with good passband shapes and low peak ripples are obtained. This is illustrated by design examples, in which 2-D filters with various shapes are designed and compared with those obtained by other existing methods.
Impact of a Ceramic Microchannel Heat Exchanger on a Micro Turbine (2002)

A highly effective recuperator with low-pressure drop is a key enabling technology to increase the efficiency of a micro turbine. To achieve a cycle efficiency above 40%, the average micro turbine would require a recuperator that achieves close to 99% effectiveness with a pressure drop as low as 2%. This paper presents the design and analysis of a microchannel heat exchanger that could be used as a recuperator in a micro turbine as an alternative to the currently used metallic primary surface recuperators that achieve an effectiveness of 90% at most. In the proposed design, the recuperator will be a counter flow, multi-layer design of parallel ducts with wall thickness of 50 μm and will be constructed with SiCN or a similar polymer derived ceramics, and fabricated using micro-stereolithography technology. Two designs, one having ducts with square cross-sections and the other with equilateral triangle cross-sections, are proposed and compared. For each design, the geometric parameters are optimized to provide the highest overall cycle efficiency while the volume of the heat exchanger is kept limited to 0.125 m3 and other cycle parameters are kept constant at typical values. For the square cross section design, the optimization process provides a design with an effectiveness of 0.961 and pressure loss of 2.86% that correspond to a cycle efficiency of 39.4%. The corresponding values for the triangle cross-section design are 0.983, 2.4% and 42.2%, respectively. Both designs are expected to withstand temperatures up to 1300°C in combustion gases. Special strategy is needed to fabricate any of these two microchannel designs by existing or proposed micro-stereolithography systems. One possible option is to make the complete heat exchanger as a bundle of identical smaller segments so that overall performance is not affected.
Epigenetic therapy is associated with similar survival compared with intensive chemotherapy in older patients with newly diagnosed acute myeloid leukemia (2012)

We reviewed the outcome of 671 patients 65 years of age or older with newly diagnosed acute myeloid leukemia (AML) treated at our institution between 2000 and 2010 with intensive chemotherapy (n = 557) or azacitidine- or decitabine-based therapy (n = 114). Both groups were balanced according to cytogenetics and performance status. The complete response rates with chemotherapy and epigenetic therapy were 42% and 28%, respectively (P = .001), and the 8-week mortality 18% and 11%, respectively (P = .075). Two-year relapse-free survival rates (28% vs 39%, P = .843) and median survival (6.7 vs 6.5 months, P = .413) were similar in the 2 groups. Multivariate analysis identified older age, adverse cytogenetics, poor performance status, elevated creatinine, peripheral blood and BM blasts, and hemoglobin, but not type of AML therapy, as independent prognostic factors for survival. No outcome differences were observed according to cytogenetics, FLT3 mutational status, age, or performance status by therapy type. Decitabine was associated with improved median overall survival compared with azacitidine (5.5 vs 8.8 months, respectively, P = .03). Survival after failure of intensive chemotherapy, azacitidine, or decitabine was more favorable in patients who had previously received decitabine (1.1 vs 0.9 vs 3.1 months, respectively, P = .109). The results of the present study show that epigenetic therapy is associated with similar survival rates as intensive chemotherapy in older patients with newly diagnosed AML. The studies reviewed are registered at www.clinicaltrials.gov as 2009-0172 (NCT00926731) and 2009-0217 (NCT00952588).
Resection planning for robotic acoustic neuroma surgery (2017)

Acoustic neuroma surgery is a procedure in which a benign mass is removed from the internal auditory canal (IAC). Currently, this surgical procedure requires manual drilling of the temporal bone followed by exposure and removal of the acoustic neuroma. This procedure is physically and mentally taxing to the surgeon. Our group is working on the development of an acoustic neuroma surgery robot (ANSR) to perform the initial drilling procedure. Planning the ANSR's drilling region using preoperative CT requires expertise and takes about 35 min. We propose an approach for automatically producing a resection plan for the ANSR that would avoid damage to sensitive ear structures and require minimal editing by the surgeon. We first compute an atlas-based segmentation of the mastoid section of the temporal bone, refine it based on the position of anatomical landmarks, and apply a safety margin to the result to produce the automatic resection plan. In experiments with CTs from nine subjects, our automated process resulted in a resection plan that was verified to be safe in every case. Approximately 2 min were required in each case for the surgeon to verify and edit the plan to permit functional access to the IAC. We measured a mean Dice coefficient of 0.99 and surface error of 0.08 mm between the final and automatically proposed plans. These preliminary results indicate that our approach is a viable method for resection planning for the ANSR and drastically reduces the surgeon's planning effort.
An amorphous silicon/chiral smectic spatial light modulator (1988)

Results are reported for a recently fabricated spatial light modulator incorporating amorphous silicon as the photoconductor and a chiral smectic liquid crystal as the modulating medium. Initial results at room temperature include an MTF of 70 LP/mm at 10% modulation with an operational frequency greater than 1 kHz.
The application of the Reaction Rate Analyser LKB 8600 as an automatic coagulometer (1977)

The application of the Reaction Rate Analyser LKB 8600 (RRA) as an automatic coagulometer is described. The RRA was slightly modified without interfering with its function as an enzyme reaction rate analyser. The endpoint of coagulation was recorded when the increase in absorbance exceeded 0.047 at lambda = 340 nm. The coagulation time was monitored by a counter with automatic print-out or by a recorder. The analytical dispersion, s(x)x, ranged between 0.01 and 0.05. Results (x, y) of the determination of the quantity of plasma coagulation factors (II + VII + X) by RRA and manually by visual recording could be expressed by y = 0.93x + 0.04, r = 0.96, n = 66 (method of Owren & Aas) or by y = 1.00x + 0.02, r = 0.98, n = 49 (Normotest). Similarly, plasma activated partial thromboplastin time (Activated Thrombofax) could be expressed by y = 0.99x + 5.00, r = 0.99, n = 23.
Grain Flow Measurement - New Developments (1989)

A mechanically robust, fully electronic grain flow meter has been developed that eliminates the mechanical errors associated with earlier attempts at such measurements and thereby provides accurate measurements of mass flow rate and/or totalised mass sufficient to meet the requirements of bulk grain handlers. The instrument may be used to measure mass flow rate and/or totalised mass of a wide range of other particulate materials with an accuracy not previously achieved with this type of instrument.
Skip List Based Authenticated Data Structure in DAS Paradigm (2009)

In database-as-a-service (DAS) computing paradigm, data owners delegate database management tasks to service provider. Since the service provider is untrusted, query authentication becomes an essential issue before database outsourcing. In previous research, various authentication data structures (ADS) have been proposed. However, most of them are either disk-based or static. Considering service provider usually owns large memory and powerful processors, in this paper we propose a dynamic main memory ADS based on skip list, which could provide efficient authentication for range query both in static and in dynamic scenarios. Experimental results confirm our claim through a systematic analysis of verification metrics.
Implementation of Graph Theory in Computer Networking To Find an EfficientRouting Algorithm (2016)

In a computer network, the transmission of data is based on the routing protocol which selects the best routes between any two nodes. Different types of routing protocols are applied to specific network environment as one routing protocol which seems to be efficient in one network seems to be inefficient in a different network especially when the number of nodes varies. RIP (Routing Information Protocol) is one of the oldest routing protocols still in service. Hop count is the metric that RIP uses and the hop limit limits the network size that RIP can support. OSPF (Open Shortest Path First) is the most widely used IGP (Interior Gateway Protocol) in large enterprise networks. EIGRP (Enhanced Interior Gateway Routing Protocol) is Cisco's proprietary routing protocol. This paper analyses which computer routing protocol performs the most efficiently. Each protocol is built around a single source shortest path algorithm. MATLAB was used to construct complex scenarios and determine which algorithms are best for graphs of variable lengths.
Changes in skeletal muscle biochemistry and histology relative to fiber type in rats with heart failure (1997)

One of the primary consequences of left ventricular dysfunction (LVD) after myocardial infarction is a decrement in exercise capacity. Several factors have been hypothesized to account for this decrement, including alterations in skeletal muscle metabolism and aerobic capacity. The purpose of this study was to determine whether LVD-induced alterations in skeletal muscle enzyme activities, fiber composition, and fiber size are 1) generalized in muscles or specific to muscles composed primarily of a given fiber type and 2) related to the severity of the LVD. Female Wistar rats were divided into three groups: sham-operated controls (n = 13) and rats with moderate (n = 10) and severe (n = 7) LVD. LVD was surgically induced by ligating the left main coronary artery and resulted in elevations (P < 0.05) in left ventricular end-diastolic pressure (sham, 5 +/- 1 mmHg; moderate LVD, 11 +/- 1 mmHg; severe LVD, 25 +/- 1 mmHg). Moderate LVD decreased the activities of phosphofructokinase (PFK) and citrate synthase in one muscle composed of type IIB fibers but did not modify fiber composition or size of any muscle studied. However, severe LVD diminished the activity of enzymes involved in terminal and beta-oxidation in muscles composed primarily of type I fibers, type IIA fibers, and type IIB fibers. In addition, severe LVD induced a reduction in the activity of PFK in type IIB muscle, a 10% reduction in the percentage of type IID/X fibers, and a corresponding increase in the portion of type IIB fibers. Atrophy of type I fibers, type IIA fibers, and/or type IIB fibers occurred in soleus and plantaris muscles of rats with severe LVD. These data indicate that rats with severe LVD after myocardial infarction exhibit 1) decrements in mitochondrial enzyme activities independent of muscle fiber composition, 2) a reduction in PFK activity in type IIB muscle, 3) transformation of type IID/X to type IIB fibers, and 4) atrophy of type I, IIA, and IIB fibers.
Adult Subependymal Neural Precursors, but Not Differentiated Cells, Undergo Rapid Cathodal Migration in the Presence of Direct Current Electric Fields (2011)

These findings suggest direct current electric fields may be implemented in endogenous repair paradigms to promote migration and tissue repair following neurotrauma.