gebhart/patrepeval huggingface dataset:
Fuzzy judgment of edge features under dynamic constraints in pedestrian tracking (2020)

In order to improve the pedestrian tracking and recognition ability, it is required to conduct fuzzy judgment to edge features. Therefore, a fuzzy judgment method of edge features under dynamic constraints in pedestrian tracking based on local motion planning and edge contour segmentation was proposed. In this method, a geometry mesh area model for pedestrian tracking and recognition was constructed, and the fuzzy dynamic feature segmentation method was adopted to reconstruct dynamic edge feature points in pedestrian tracking to extract the greyscale pixel set under dynamic constraints in pedestrian tracking. The simulation results show that in pedestrian tracking and recognition, this method has strong fuzzy judgment ability of edge features and can provide results with error below 10 mm and relatively stable fluctuation, so this method can provide relatively high recognition accuracy and good robustness.
Peptide receptor radionuclide therapy in vitro using [111In-DTPA0]octreotide. (2003)

These in vitro studies show that the therapeutic effect of (111)In is dependent on internalization, enabling the Auger electrons with their very short particle range to reach the nucleus. Our results also indicate that the PRRT effects were receptor mediated.
SWITCH1 (SWI1): a novel protein required for the establishment of sister chromatid cohesion and for bivalent formation at meiosis (2001)

We have characterized a new gene, SWI1 , involved in sister chromatid cohesion during both male and female meiosis in Arabidopsis thaliana . A first allele, swi1.1 , was obtained as a T-DNA tagged mutant and was described previously as abnormal exclusively in female meiosis. We have isolated a new allele, swi1.2 , which is defective for both male and female meiosis. In swi1.2 male meiosis, the classical steps of prophase were not observed, especially because homologs do not synapse. Chromatid arms and centromeres lost their cohesion in a stepwise manner before metaphase I, and 20 chromatids instead of five bivalents were seen at the metaphase plate, which was followed by an aberrant segregation. In contrast, swi1.2 female meiocytes performed a mitotic-like division instead of meiosis, indicating a distinct role for SWI1 or a different effect of the loss of SWI1 function in both processes. The SWI1 gene was cloned; the putative SWI1 protein did not show strong similarity to any known protein. Plants transformed with a SWI1–GFP fusion indicated that SWI1 protein is present in meiocyte nuclei, before meiosis and at a very early stage of prophase. Thus, SWI1 appears to be a novel protein involved in chromatid cohesion establishment and in chromosome structure during meiosis, but with clear differences between male and female meiosis.
今后十年生物技术商业化的十个主要领域——《遗传工程新闻》的预测 (1990)

分析家们普遍认为生物技术本身并非真正的产业,而只是通过分子生物学发展起来的一系列手段.它们正在使美国及国外的部分产业发生变革。基于上述观点,《遗传工程新闻》预测了生物技术商业化潜力最大的十个领域。
Long-term maintenance of patterns of hippocampal pyramidal cells on substrates of polyethylene glycol and microstamped polylysine (2000)

For neurons to attach and remain in precise micropatterns for weeks in culture, background molecules that remain nonpermissive for extended culture durations need to be identified. Nonpermissive background molecules of either polyethylene glycol (PEG) or the amino acid serine (C3H7NO3) were evaluated. The foreground regions were microstamped with 3-, 5-, or 10-micron lines of poly-D-lysine (PDL), which promotes neural attachment and growth. After 29 days in culture the foreground compliance, or the fraction of all live somata which rested on the desired PDL surface, averaged 86% for serine and 90% for PEG, with only a small decline. The background compliance, or the fraction of square areas in the pattern background which were free of neurite extension, declined from highs of 40% and 55% (midculture) to 5.5% and 12% (29 days) for serine and PEG, respectively. Images of the cultures suggest that PEG is significantly more effective as a nonpermissive substrate. We conclude that these materials, especially PEG, are adequate for the maintenance of long-term patterned cultures of neurons. We believe that this is the first report of high-quality long-term patterning of cultured neurons.
Beyond 5-fluorouracil: new horizons in systemic therapy for advanced colorectal cancer (2005)

Worldwide, colorectal cancer is a common cancer and a major cause of morbidity and mortality. Patients frequently present with, or later develop, metastatic disease. Median survival with supportive care alone is approximately 6 - 8 months. However, a number of recent developments have greatly increased the range of therapeutic options, improving median survival to > 20 months. Cytotoxic agents such as capecitabine, irinotecan and oxaliplatin are now established treatment strategies. In parallel, an improved understanding of tumour biology has led to the development of non-cytotoxic targeted therapies. Examples include bevacizumab (targeting tumour angiogenesis) and cetuximab (targeting the epidermal growth factor receptor). These agents have recently been incorporated into standard management. This paper reviews these and other advances in the care of patients with advanced colorectal cancer and discusses a number of agents that are currently under development.
Extranuclear Coactivator Signaling Confers Insensitivity to Tamoxifen (2009)

These findings suggest that PELP1 localization could be used as a determinant of hormone sensitivity or vulnerability. The establishment of the PELP1-cyto transgenic mouse model is expected to facilitate the development of preclinical approaches for effective intervention of breast tumors using cytoplasmic coregulators and active nongenomic signaling.
Toward a Kinesthetics of Protest (2006)

Gatherings in protest are also occasions for the socialization of the body politic, moments when principles for living together among strangers are put on display. In what follows, I will treat images of protest for their principles of assemblage and exclusion. The power to still social life gives it in the same breath. Each protest is a gesture of arrest that unleashes its own kinesthetic.
EZH2 mutational status predicts poor survival in myelofibrosis (2011)

We genotyped 370 subjects with primary myelofibrosis (PMF) and 148 with postpolycythemia vera/postessential thrombocythemia (PPV/PET) MF for mutations of EZH2. Mutational status at diagnosis was correlated with hematologic parameters, clinical manifestations, and outcome. A total of 25 different EZH2 mutations were detected in 5.9% of PMF, 1.2% of PPV-MF, and 9.4% of PET-MF patients; most were exonic heterozygous missense changes. EZH2 mutation coexisted with JAK2V617F or ASXL1 mutation in 12 of 29 (41.4%) and 6 of 27 (22.2%) evaluated patients; TET2 and CBL mutations were found in 2 and 1 patients, respectively. EZH2-mutated PMF patients had significantly higher leukocyte counts, blast-cell counts, and larger spleens at diagnosis, and most of them (52.6%) were in the high-risk International Prognostic Score System (IPSS) category. After a median follow-up of 39 months, 128 patients (25.9%) died, 81 (63.3%) because of leukemia. Leukemia-free survival (LFS) and overall survival (OS) were significantly reduced in EZH2-mutated PMF patients (P = .028 and P < .001, respectively); no such impact was seen for PPV/PET-MF patients, possibly due to the low number of mutated cases. In multivariate analysis, survival of PMF patients was predicted by IPSS high-risk category, a < 25% JAK2V617F allele burden, and EZH2 mutation status. We conclude that EZH2 mutations are independently associated with shorter survival in patients with PMF.
Colonization of the porcine gastrointestinal tract by lactobacilli (1989)

Eight strains of lactobacillus isolated from the porcine gastrointestinal tract were tested for their ability to adhere in vitro to cells collected from stratified squamous epithelium in the digestive tracts of newborn piglets. Piglets were inoculated with individual strains, and their digestive tracts were sampled at intervals to determine the colonizing ability of the lactobacilli. The results of the in vitro test did not predict whether a lactobacillus strain would associate with stratified squamous epithelium in the piglet digestive tract, but epithelial association in vivo appeared to be an important factor in the maintenance of lactobacillus populations in the tract. None of the lactobacillus strains used as inocula was numerically dominant in the tract 7 days after inoculation of the piglets with a single dose of the bacteria.
Dendrimer-Based Nanoprobe for Dual Modality Magnetic Resonance and Fluorescence Imaging (2006)

A novel PAMAM dendrimer-based nanoprobe for dual magnetic resonance and fluorescence imaging modalities was synthesized. Fluorescence studies revealed that Gd(III) complexation to the probe has no effect on the quantum yield; however, increases in the dye content resulted in partial quenching. The potential of the new nanoprobe, G6-(Cy5.5)(1.25)(1B4M-Gd)(145), as a dual modality imaging agent was demonstrated in vivo by the efficient visualization of sentinel lymph nodes in mice by both MRI and fluorescence imaging modalities.
A New Method of Instantaneous Ambiguity Resolution (1994)

The objective of the work reported here was to develop a
method of ambiguity resolution that is fast and robust in
the face of the signal reception environment of commer-
cially-viable attitude determination systems. The method
achieved is fully optimum. If there are a trillion integer
combinations, the method finds the single most likely
combination out of all trillion, and makes it possible to
prove that this has actually occurred. The method avoids
double differencing. With short antenna separations, it
can withstand phase measurement errors up to 40” RMS.
With the more typical interferometry measurement accu-
racy of 10” RMS, with antenna cable drifts of 5” RMS,
with 4 satellites in track, and with 4 antennas on the cor-
ners of a 2-meter square, the method produces attitude
solutions on 99.3% of update cycles,’ with an average
computation time of 0.24 seconds on a 486 PC, and with
an RMS azimuth solution accuracy of 0.07’. The method
is the basis of instantaneous ambiguity resolution in one
operating regime2 of Trimble’s new Vector Attitude
Determination System. Performance results being ob-
tained with Trimble’s equipment are summarized. The
significance of this work is in developing a general, op-
timal solution for resolving carrier cycle ambiguities in a
wide range of applications.
The attitude determination problem is formulated as
a maximum-likelihood optimization, in which vehicle
attitude and the carrier cycle integers are regarded as
parameters to be adjusted to maximize the probability of
interferometric measurements obtained by GPS receiving
hardware. The formulation results in weighted-fit-error
W as the objective criterion to minimize. A Kalman
filter is introduced, having the same objective criterion.
Minimizing computation in the Kalman filter leads to a
decision tree for the integers. Two ways are shown to
prune the tree. The first is to exclude impossible combi-
nations, and the second is to generate a lower bound for
W at each branch of the tree. A running sum is kept at
each stage moving down the tree. When that sum ex-
ceeds the current best W found elsewhere in the search,
it is guaranteed that all subsequent integer combinations
further down the current branch will produce an even
larger W, and cannot be optimum. The remainder of the
current branch is then cut off, speeding up the search.
Accurate gas diagnostics for sealed-off CO/sub 2/ lasers using near-infrared DFB semiconductor lasers (1998)

The selective spectroscopic detection of CO/sub 2/ and H/sub 2/O in the gas mixture of a 400-W sealed-off CO/sub 2/ slab laser is reported. The detection is based on the acquisition of absorption Voigt profiles of two vibrational overtone transitions of CO/sub 2/ and H/sub 2/O, obtained using two InGaAsP distributed feedback (DFB) semiconductor lasers. This spectroscopic method enables a direct absolute measurement of the temporal evolution for the concentrations inside the laser active volume. Monitoring takes place during laser operation without gas extraction. The experiments carried out on CO/sub 2/ and H/sub 2/O abundances confirm the paramount importance of wall desorbance phenomena in all-metal radio frequency (RF) excited lasers.
Technology in the Rural Industry, Expert Systems and Farm Management (1988)

To remain competitive, farming is going to require greater managerial skills than in the past as margins for profits are reduced. Information science will play a central role by giving farmers and their advisers the means of accessing the latest technology from agricultural research and testing it for likely benefits under local conditions using simulation techniques. While such technology has had rather little impact on broad-acre agriculture to date, the use of decision support systems based on simulation models and expert systems is increasing.
Crumpled structure of the custom hydrophobic lytic peptide cecropin B3 (2001)

The solution structure of a custom lytic peptide, cecropin B3 (CB3), having two identical hydrophobic segments on both the N- and C-termini, was investigated by two-dimensional NMR spectroscopy. The need to determine the structure of this peptide is rooted in its specific ability to lyse lipid layers that have a high content of anionic lipid. The lytic activities of CB3 on cell membranes including cancer cells and bacteria is found to be less than cecropin B1. The results show that CB3 has four discrete segments forming alpha helical structures. The crumpled structure of CB3 provides evidence for the lysis of the lipid layer being via a pathway that differs from pore formation. The results in this study provide strong clues towards a rational design for a potent antimicrobial and antitumor peptide.
An efficient deblocking filter architecture with 2-dimensional parallel memory for H.264/AVC (2005)

In this paper, we present an efficient architecture for deblocking filter in H.264/AVC. A novel 2-dimensional parallel memory scheme is employed in order to achieve highly efficient parallel access in both horizontal and vertical directions. By using this parallel memory scheme, we also eliminate the need for a transpose circuit. Our design is implemented under 0.35/spl mu/m technology. Synthesis results show that the equivalent gate count is only 9.35K (not including SRAMs) when the maximum frequency is 100MHz.
Seroresponses to virus-like particles of human papillomavirus types 16, 18, 31, 33, and 45 in San People of Southern Africa (2000)

Virus-like particles (VLPs) of the high-risk human papillomavirus (HPV) types 16, 18, 31, 33, and 45 were used as antigen in enzyme-linked immunosorbent assay (ELISA) to determine the prevalence of serum IgG in a group of San people originally from Namibia, now residing in South Africa. The San children had low seroprevalence to all VLP types, but 26/115 (22.6%) of the children were seropositive to at least 1 VLP type. Among the adults, seroprevalence was significantly higher. The seroprevalence of antibodies in 101 San women to VLP-16 was 16.8%, VLP-18 18.8%, VLP-31 12.9%, VLP-33 17.8%, and VLP-45 22.8%. Five of the 11 men were seropositive: 2 for VLP-31, 1 for VLP-18, 1 for VLP-33, and 1 for VLP-45. Seroreactivity appeared to be type specific, except possibly to VLP-18 and -45. Of the adults, 50.5% were seropositive to at least 1 VLP type and 24.8% were seropositive to >1 VLP type. From this study, it is concluded that the San people are exposed to HPV-16, -18, -31, -33, and -45, with antibodies to VLP-45 being the most prevalent.
A Multimode/Multiband Envelope Tracking Transmitter With Broadband Saturated Amplifier (2011)

A multimode/multiband envelope tracking (ET) transmitter consisting of a hybrid switching amplifier (HSA) and a broadband saturated power amplifier (PA) is developed for operation across 1.3 to 2.7 GHz. For the various standard signals with different bandwidth (BW) and peak-to-average power ratio, the HSA efficiently provides supply signals to the PA by changing the reference value of the hysteresis comparator. The saturated amplifier employs the nonlinear output capacitor to shape the voltage waveform, resulting in the half-sinusoidal or rectangular waveform. Since the nonlinear capacitor generates large out-of-phased second harmonic component with small higher order harmonics, the voltage shaping is mainly carried out by the capacitor and slightly supported by the harmonic loading circuit. Thus, with the harmonic load higher than that of output capacitor, the saturated amplifier can operate with high efficiency. This characteristic enables the saturated PA to operate with broadband characteristic and high efficiency because the design is mainly focused on the fundamental matching problem while the harmonics can be easily kept out of a low efficiency region through the subsequent optimization of the matching circuit. The broadband saturated PA is implemented based on load/source-pull methodology. The broadband matching networks for the high efficiency are synthesized using the simplified real frequency technique. For the BW from 1.3 to 2.7 GHz (70% fractional BW), the measured output power, drain efficiency, and power-added efficiency (PAE) performances are between 39.8-42.0 dBm, 55.8-69.7%, and 51.2-65.3%, respectively. The multimode/multiband ET transmitter with the designed broadband saturated PA is demonstrated at 1.8425-GHz long-term evolution (LTE), 2.14-GHz wideband code division multiple access (WCDMA), and 2.6-GHz mobile world wide interoperability for microwave access (m-WiMAX) applications. This transmitter delivers a PAE of 32.16, 37.24, and 28.75% for LTE, WCDMA, and m-WiMAX applications.
Very fast empirical prediction and rationalization of protein pK<sub>a</sub> values (2005)

A very fast empirical method is presented for structure-based protein pKa prediction and rationalization. The desolvation effects and intra-protein interactions, which cause variations in pKa values of protein ionizable groups, are empirically related to the positions and chemical nature of the groups proximate to the pKa sites. A computer program is written to automatically predict pKa values based on these empirical relationships within a couple of seconds. Unusual pKa values at buried active sites, which are among the most interesting protein pKa values, are predicted very well with the empirical method. A test on 233 carboxyl, 12 cysteine, 45 histidine, and 24 lysine pKa values in various proteins shows a root-mean-square deviation (RMSD) of 0.89 from experimental values. Removal of the 29 pKa values that are upper or lower limits results in an RMSD = 0.79 for the remaining 285 pKa values.
Diet and Uptake of Aldomet by the Brain: Competition with Natural Large Neutral Amino Acids (1977)

The rise in levels of aldomet in the brains of rats after an injection of the alpha-methylated amino acid was depressed when large neutral amino acids, but not acidic amino acids, were coadministered with the drug. This result suggests that aldomet is transported into brain by the carrier for natural large neutral amino acids. The prior ingestion of a carbohydrate meal, which lowers levels of neural amino acids in the serum, enhanced the uptake of aldomet into brain; the consumption of a protein-containing meal inhibited the subsequent uptake of aldomet into the brain. Antecedent diet can thus affect the availability of aldomet to the central nervous system; the mechanism of this effect probably involves the blood-brain barrier uptake system for large neutral amino acids.
Complications of the COX-2 Inhibitors Parecoxib and Valdecoxib after Cardiac Surgery (2005)

The use of parecoxib and valdecoxib after CABG was associated with an increased incidence of cardiovascular events, arousing serious concern about the use of these drugs in such circumstances.
A massively parallel computational electrophysiology model of the heart (2011)

Abstract This paper presents a patient‐sensitive simulation strategy capable of using the most efficient way the high‐performance computational resources. The proposed strategy directly involves three different players: Computational Mechanics Scientists (CMS), Image Processing Scientists and Cardiologists, each one mastering its own expertise area within the project. This paper describes the general integrative scheme but focusing on the CMS side presents a massively parallel implementation of computational electrophysiology applied to cardiac tissue simulation. The paper covers different angles of the computational problem: equations, numerical issues, the algorithm and parallel implementation. The proposed methodology is illustrated with numerical simulations testing all the different possibilities, ranging from small domains up to very large ones. A key issue is the almost ideal scalability not only for large and complex problems but also for medium‐size meshes. The explicit formulation is particularly well suited for solving this highly transient problems, with very short time‐scale. Copyright © 2011 John Wiley & Sons, Ltd.
Artefacts in Image and Video Systems: Classification and Mitigation (2002)

Clodronate (disodium clodronate tetrahydrate) is a bisphosphonate used in the treatment of hypercalcemia and osteolysis due to malignancy. Like all bisphosphonates, clodronate has low and variable oral bioavailability. The purpose of this study was to examine the absolute bioavailability of clodronate from two different oral doses. Thirty-one healthy young volunteers participated in this open, randomized, three-period, single-dose, cross-over study. The absolute bioavailability was calculated from the area under the serum clodronate-time curve in 48 h (AUC(0-48 h)) after administration of 800 or 1600 mg (Bonefos 400 mg capsules) of oral clodronate, or 30 mg (Bonefos 60 mg/mL infusion concentrate) of intravenous clodronate. The maximum concentration of clodronate in serum (C(max)), the time to maximum concentration (t(max)), the elimination half-life (t(1/2)), and the cumulative amount of clodronate excreted into urine in 48 h (Ae(0-48 h)) were also determined. The geometric mean of the absolute bioavailability of 800 mg of clodronate was 1.9% and that of 1600 mg 2.1%. The difference in the absolute bioavailability of these two doses was statistically nonsignificant. All treatments were well tolerated, and the AE profiles were similar in the different treatment groups. There were no serious adverse events during the study.
Programmable image associative memory using an optical disk and a photorefractive crystal (1993)

The optical disk is a computer-addressable binary storage medium with very high capacity. More than 1010 bits of information can be recorded on a 12-cm-diameter optical disk. The natural two-dimensional format of the data recorded on an optical disk makes this medium particularly attractive for the storage of images and holograms, while parallel access provides a convenient mechanism through which such data may be retrieved. In this paper we discuss a closed-loop optical associative memory based on the optical disk. This system incorporates image correlation, using photorefractive media to compute the best association in a shift-invariant fashion. When presented with a partial or noisy version of one of the images stored on the optical disk, the optical system evolves to a stable state in which those stored images that best match the input are temporally locked in the loop.