gebhart/patrepeval huggingface dataset:
A one-letter notation for amino acid sequences. Tentative rules (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA one-letter notation for amino acid sequences. Tentative rules. IUPAC-IUB Comm. on Biochem. NomenclatureCite this: Biochemistry 1968, 7, 8, 2703–2705Publication Date (Print):August 1, 1968Publication History Published online1 May 2002Published inissue 1 August 1968https://doi.org/10.1021/bi00848a001RIGHTS & PERMISSIONSArticle Views177Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (281 KB) Get e-Alerts Get e-Alerts
Penyakit Jantung Rematik pada Anak Laki-laki Usia 8 Tahun (2017)

Gagal jantung adalah keadaan ketidakmampuan jantung untuk memompa cukup darah ke seluruh tubuh sesuai dengan pemenuhan kebutuhan tubuh. Pada anak, salah satu etiologi paling sering penyebab gagal jantung adalah penyakit jantung rematik yang merupakan sekuel dari demam reumatik, suatu infeksi yang diakibatkan Streptococcus grup A. Seorang anak laki-laki usia 8 tahun datang dengan keluhan sesak napas saat beraktivitas, batuk berdahak, nyeri sendi, demam ringan yang hilang timbul, dan pembesaran skrotum yang mulai dirasakan sejak 1 bulan sebelum masuk rumah sakit. Pada pemeriksaan fisik didapatkan frekuensi nadi 110x/m, frekuensi napas 32 x/m, terdapat peningkatan Jugular Venous Pressure (JVP), murmur pansistolik dengan derajat 4/6 disertai thrill, pembesaran batas jantung, ronki basah halus pada seluruh lapang paru, hepar teraba membesar dengan tepi tumpul dan pembesaran skrotum konsistensi lunak namun tidak hiperemis. Pada pemeriksaan penunjang hasil laboratorium menunjukkan peningkatan laju endap darah (LED), anti-streptolisin O (ASTO) positif dengan C- Reactive Protein (CRP) kuantitatif >12 mg/L; foto toraks menunjukkan kesan kardiomegali; pemanjangan interval PR pada elektrokardiografi (EKG) dan hasil ekokardiografi menunjukkan regurgitasi mitral beratet causa Rheumatic Heart Disease (RHD) dan regurgitasi mitral ringan. Pasien didiagnosa dengan penyakit jantung rematik dengan gagal jantung New York Heart Association (NYHA) II. Pasien diberikan tatalaksana tirah baring dan oksigenasi, diuretik, Angiotensin Converting Enzyme Inhibitor (ACEI), antibiotik, dan steroid. Kata kunci: gagal jantung, penyakit jantung rematik
Understanding Resolvin Signaling Pathways to Improve Oral Health (2013)

The discovery of resolvins has been a major breakthrough for understanding the processes involved in resolution of inflammation. Resolvins belong to a family of novel lipid mediators that possess dual anti-inflammatory and pro-resolution actions. Specifically, they protect healthy tissue during immune-inflammatory responses to infection or injury, thereby aiding inflammation resolution and promoting tissue healing. One of the major concerns in modern medicine is the management and treatment of oral diseases, as they are related to systemic outcomes impacting the quality of life of many patients. This review summarizes known signaling pathways utilized by resolvins to regulate inflammatory responses associated with the oral cavity.
Synthesis of derivatives of pyrazino[1,2‐<i>a</i>]pyrimidin‐4‐ones (1990)

Abstract 3‐Alkoxy‐2‐aminopyrazines have been condensed with ethyl ethoxymethylenemalonate and isopropylidene methoxymethylenemalonate to afford 9‐alkoxypyrazino[1,2‐ a ]pyrimidin‐4‐ones substituted in the first case by an ethoxycarbonyl group at 3 position.
Nanotechnology and vaccine development (2014)

Despite the progress of conventional vaccines, improvements are clearly required due to concerns about the weak immunogenicity of these vaccines, intrinsic instability in vivo, toxicity, and the need for multiple administrations. To overcome such problems, nanotechnology platforms have recently been incorporated into vaccine development. Nanocarrier-based delivery systems offer an opportunity to enhance the humoral and cellular immune responses. This advantage is attributable to the nanoscale particle size, which facilitates uptake by phagocytic cells, the gut-associated lymphoid tissue, and the mucosa-associated lymphoid tissue, leading to efficient antigen recognition and presentation. Modifying the surfaces of nanocarriers with a variety of targeting moieties permits the delivery of antigens to specific cell surface receptors, thereby stimulating specific and selective immune responses. In this review, we introduce recent advances in nanocarrier-based vaccine delivery systems, with a focus on the types of carriers, including liposomes, emulsions, polymer-based particles, and carbon-based nanomaterials. We describe the remaining challenges and possible breakthroughs, including the development of needle-free nanotechnologies and a fundamental understanding of the in vivo behavior and stability of the nanocarriers in nanotechnology-based delivery systems.
Soil Metals Analysis Using Laser‐Induced Breakdown Spectroscopy (LIBS) (2009)

Laser‐induced breakdown spectroscopy (LIBS) is an elemental analysis technique that is based on the measurement of atomic emissions generated on a sample surface by a laser‐induced microplasma. Although often recognized in the literature as a well‐established analytical technique, LIBS remains untested relative to the quantitative analysis of elements in chemically complex matrices, such as soils. The objective of this study was to evaluate the capabilities of LIBS relative to the elemental characterization of surface soils. Approximately 65 surface soil samples from the Pond Creek watershed in east Tennessee were collected and subjected to total dissolution and elemental analysis by inductively coupled argon plasma‐optical emission spectroscopy (ICP–OES). The samples were analyzed by LIBS using a Nd:YAG laser at 532 nm, with a beam energy of 25 mJ per pulse, a pulse width of 5 ns, and a repetition rate of 10 Hz. The wavelength range for the LIBS spectra collection was 200 to 600 nm, with a resolution of 0.03 nm. Elemental spectral lines were identified through the analysis of analytical reagent‐grade chemicals and the NIST and Kurucz spectral databases. The elements that dominated the LIBS spectra were Al, Ca, Fe, and Mg. In addition, emission lines for Ti, Ba, Na, Cu, and Mn were isolated. The emission lines of Cr, Ni, and Zn, which were >100 mg kg −1 in numerous soil samples, were not detected. Further, spectral emission lines for P and K are >600 nm, eliminating them from LIBS analysis. The integrated peak areas of interference‐free elemental emission lines were determined, then normalized to the area of the 288.16 nm Si(I) emission (internal standard) to reduce the variability between replicate analyses. The normalized spectral areas, coupled with linear regression (standard curves for single wavelength response) and multivariate techniques (chemometrics and multiple wavelengths), were used to predict ICP–OES elemental data. In general, the quantitative capabilities of LIBS proved disappointing. Detection and quantitation were generally restricted to those elements with concentrations > 0.5 g kg −1 The correlation between LIBS response and elemental content was poor ( r < 0.98). Further, the relative errors of prediction for the LIBS‐detected elements were less than acceptable for an analytical technique (<20%), ranging from ∼20 to ∼40% using linear regression analysis, and from 18 to 48% using partial least squares analysis. Based on these findings, the analytical capability of the LIBS method for soil metals analysis should be considered questionable.
Role of arginine-292 in the substrate specificity of aspartate aminotransferase as examined by site-directed mutagenesis (1988)

X-ray crystallographic data have implicated Arg-292 as the residue responsible for the preferred side-chain substrate specificity of aspartate aminotransferase. It forms a salt bridge with the beta or gamma carboxylate group of the substrate [Kirsch, J. F., Eichele, G., Ford, G. C., Vincent, M. G., Jansonius, J. N., Gehring, H., & Christen, P. (1984) J. Mol. Biol. 174, 497-525]. In order to test this proposal and, in addition, to attempt to reverse the substrate charge specificity of this enzyme, Arg-292 has been converted to Asp-292 by site-directed mutagenesis. The activity (kcat/KM) of the mutant enzyme, R292D, toward the natural anionic substrates L-aspartate, L-glutamate, and alpha-ketoglutarate is depressed by over 5 orders of magnitude, whereas the activity toward the keto acid pyruvate and a number of aromatic and other neutral amino acids is reduced by only 2-9 fold. These results confirm the proposal that Arg-292 is critical for the rapid turnover of substrates bearing anionic side chains and show further that, apart from the desired alteration, no major perturbations of the remainder of the molecule have been made. The activity of R292D toward the cationic amino acids L-arginine, L-lysine, and L-ornithine is increased by 9-16-fold over that of wild type and the ratio (kcat/KM)cationic/(kcat/KM)anionic is in the range 2-40-fold for R292D, whereas this ratio has a range of [(0.3-6) x 10(-6)]-fold for wild type. Thus, the mutation has produced an inversion of the substrate charge specificity.(ABSTRACT TRUNCATED AT 250 WORDS)
Magnetic field-induced semimetal-to-semiconductor transition in InAs-GaSb superlattices (1980)

With the application of a magnetic field, we have observed a semimetal-to-semiconductor transition in InAs-GaSb superlattices with closely overlapped subbands of electrons and holes. The transition is manifested in a sharp increase in the magnetoresistance in the quantum limit, where the ground Landau levels associated with the subbands are crossed at the Fermi level, resulting in carrier depletion.
Fetal Cardiographic Monitoring During 1.5-T MR Imaging (2003)

Fetal cardiotocography is feasible during MR imaging using modified standard equipment. The use of 1.5-T MR imaging appears to be safe and to have no negative short-term effects on the heart rate or movement incidence of healthy third-trimester fetuses under our experimental conditions.
Partial Characterisation of an Oncofetal Pancreatic Antigen (1981)

An oncofetal pancreatic antigen (OPA) has been identified and purified from the blood of patients with pancreatic cancer. Characterisation studies on OPA have shown that it is a protein of molecular weight 40 000 with alpha2 electrophoretic mobility. OPA is clearly different from alpha-fetoprotein, carcinoembryonic antigen, ferritin, acute phase reactants, and normal serum proteins. A rocket immunoassay has been developed allowing the quantitation of OPA in serum; it has been applied to samples from over 700 individuals with a variety of conditions. Elevated levels of OPA have been found in 42 of 48 (88%) patients with biopsy-proven pancreatic cancer and in a much smaller percentage of patients with other cancers or with other conditions considered in the differential diagnosis of pancreatic cancer. The studies indicate that serum OPA measurements may be useful as a preliminary screening test for pancreatic cancer and for monitoring the course of the disease.
An Exploratory Study of the Introduction of Online Reverse Auctions (2003)

Buyers are increasingly turning to online reverse auctions in their negotiations with suppliers. How do these price competition mechanisms affect buyer–supplier relationships? The author considers this question in the context of a quasi experiment involving six online reverse auctions conducted in the supply base of a major industrial buyer. The results indicate that these auctions increase both new and current suppliers’ beliefs that buyers act opportunistically, particularly in open-bid auctions. Current suppliers are generally more willing than new suppliers to make dedicated investments toward the buyer. Paradoxically, in sealed-bid auctions, both current and new suppliers increase their willingness to make dedicated investments toward the buyer. Although these auctions can yield cost savings, the savings are category specific and are not systematically related to an open- or sealed-bid format. The author also discusses implications for the use of online reverse auctions in industrial sourcing activities.
Optical binding between dielectric particles (2004)

We report observation of optical binding between two dielectric particles with dimensions less than the wavelength of the interacting light. The observed dependence of the separation of optically bound Rayleigh particles on the polarization of the trapping beam is in agreement with earlier theoretical predictions.
Markov Regression Models for Time Series: A Quasi-Likelihood Approach (1988)

This paper discusses a quasi-likelihood (QL) approach to regression analysis with time series data. We consider a class of Markov models, referred to by Cox (1981, Scandinavian Journal of Statistics 8, 93-115) as "observation-driven" models in which the conditional means and variances given the past are explicit functions of past outcomes. The class includes autoregressive and Markov chain models for continuous and categorical observations as well as models for counts (e.g., Poisson) and continuous outcomes with constant coefficient of variation (e.g., gamma). We focus on Poisson and gamma data for illustration. Analogous to QL for independent observations, large-sample properties of the regression coefficients depend only on correct specification of the first conditional moment.
Post-processing pathways in carbon capture and storage by mineral carbonation (CCSM) towards the introduction of carbon neutral materials (2012)

Carbon dioxide capture and storage by mineral carbonation (CCSM) is a technology that can potentially sequester billions of tonnes of carbon dioxide (CO2) per year. Despite this large potential, the costs of CCSM are currently too high for a large deployment of the technology and new systems are being investigated to attempt to overcome these limitations. To improve this situation, the successful development of post-processing routes creating marketable carbon neutral products could help the deployment of mineral carbonation. This work investigates the current market for CCSM products and the role they can play in decreasing the overall cost of CCSM technology. The current global market for the raw commodities, primarily cement additives, fillers and iron ore feedstock which could be produced by rock and/or industrial waste/by-product mineralisation, is about 27.5 Gt and can be easily flooded assuming 10% of the global CO2 emissions sequestered by CCSM. The CCSM technology chosen will play a very important role in the products created, available post-processing routes and accessible markets if the resultant materials are of high purity. Low-value applications such as fill for land reclamation may represent the only viable opportunity at the current state of the technology, bearing in mind that these materials are competing with low-cost materials (i.e. crushed rock) and that the size distribution of the carbonated materials may need significant alteration to make them potentially useful. However, there is a lack of information available on the quality of the CCSM products towards access to high-value markets such as micro-silica and PCC. In summary, CCSM post-processing might be viable only in niche high-value markets, while low-value applications such as land/mine reclamation are potentially more feasible and could be able to absorb Gts of CCSM products.
Immunogenicity against Human Papillomavirus Type 16 Virus-Like Particles Is Strongly Enhanced by the PhoP<sup>c</sup>Phenotype in<i>Salmonella enterica</i>Serovar Typhimurium (2004)

Recombinant Salmonella strains have been widely used to deliver heterologous antigens and induce immune responses in vaccinated animals and humans. It remains to be established, however, how these bacteria mount an immune response; this has prevented the rational design of vaccines. Here we report for the first time that a particular genetic program, PhoPc, is necessary for recombinant Salmonella strains to induce an antibody response to a heterologous antigen, the human papillomaviruses type 16 (HPV16) virus-like particle (VLP). The PhoPc phenotype results from a point mutation in phoQ, the gene encoding the sensor component of a two-component regulatory system (PhoP-PhoQ) that controls the expression of a number of virulence factors in Salmonellae. To demonstrate that immunogenicity of the viral antigen expressed by the bacterial vector was dependent on the PhoPc phenotype, we have expressed the phoQ mutant gene (phoQ24) in two differently attenuated Salmonella enterica serovar Typhimurium strains. Our data show extrachromosomal phoQ24 to be dominant over the chromosomal copy of the phoQ gene, conferring the PhoPc phenotype on the recipient strains. In addition, activation of PhoPQ-regulated genes by the plasmid-encoded PhoQ24 did not alter bacterial survival and conferred immunogenicity to the HPV16 VLP expressed in the two S. enterica serovar Typhimurium backgrounds, inducing the production of HPV-specific antibodies in mice. This strongly suggests that at least one of the PhoP-regulated genes is necessary for mounting an efficient antibody response to HPV16 VLP. This finding sets the stage for further development of a Salmonella-based vaccine against HPV infection and cervical cancer.
Experimental studies in magnetically induced transverse force-frequency effect in thin quartz microresonators (2015)

In this work, the transverse force-frequency sensitivity of magnetostrictive Metglas® (Fe85B5Si10) thin film coated AT-cut thickness shear mode quartz thin plate microresonator (500 μm × 500 μm × 19 μm) is experimentally measured and modeled in Lagrangian formulation by coupling magnetostrictive deformation equations with the basic plate equations from the theory of small deformation. The quartz plate resonator is fabricated by micromachining techniques and released into fixed-free structure using focused ion beam milling. Application of a magnetic field results in the out-of-plane bending of the structure due to elastic coupling between the magnetostrictive Metglas® and quartz resonator layers. As a result of the transverse loading and out-of-plane bending, the admittance characteristics of the resonator shifts, and these shifts are recorded in real time utilizing a network analyzer. The sensitivity is experimentally measured to be 162.3 mdeg/Oe for phase, corresponding to a frequency sensitivity of Δf/H = 11 Hz/Oe. The equivalent force-frequency sensitivity can then be calculated as 2.36 μN/Hz using the developed model. The coupled domain analysis fits well with the experimental data. Further reduction of quartz thickness and optimization of the thickness ratio of the magnetostrictive to quartz layers offers the possibility of exploiting the stress sensitivity of plate microresonators as sensitive magnetic field sensors capable of low nanoTesla to picoTesla level magnetic flux densities.
Effects of Concentration, Bloom Degree, and pH on Gelatin Melting and Gelling Temperatures Using Small Amplitude Oscillatory Rheology (2007)

Concentration, gel strength (Bloom), and pH effects on both melting and gelling temperatures of gelatin were studied using small amplitude oscillatory rheology. Temperature sweeps were applied to gelatin gel samples for heating and cooling at fixed frequencies. Results showed that melting temperatures were higher than gelling temperatures, and both increased with increasing concentration at pH from 3 to 6 for all gel strength. For constant gelatin concentration and pH, as gel strength increased, melting temperatures decreased, whereas gelling temperatures increased. A mathematical model was obtained which correlates melting and gelling temperatures, respectively, with pH and concentration at fixed Bloom degrees. All gelatin gels showed storage modulus higher (2 to 10 kPa) than loss modulus (50 to 500 Pa).
<b>Acylations of Ketals and Enol Ethers</b> (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAcylations of Ketals and Enol EthersRaymond D. YoussefyehCite this: J. Am. Chem. Soc. 1963, 85, 23, 3901–3902Publication Date (Print):December 1, 1963Publication History Published online1 May 2002Published inissue 1 December 1963https://pubs.acs.org/doi/10.1021/ja00906a047https://doi.org/10.1021/ja00906a047research-articleACS PublicationsRequest reuse permissionsArticle Views104Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Influence of osmolarity on lipopolysaccharides and virulence of Aeromonas hydrophila serotype O:34 strains grown at 37 degrees C (1997)

Growth of Aeromonas hydrophila serotype O:34 strains at 37 degrees C at low and high osmolarity resulted in changes in the lipopolysaccharide (LPS) and virulence of the strains tested. We previously described the effect of growth temperature on LPS and virulence of these strains (S. Merino et al., Infect. Immun. 60:4343-4349, 1992). The effect of osmolarity can be observed when the cells grow at 37 degrees C but not when they grow at 20 degrees C. Purified LPS from cells cultivated at 37 degrees C and high osmolarity was smooth, while the LPS extracted from the cells cultivated at low osmolarity was rough. Furthermore, the strains were more virulent for fish and mice when they were grown at high osmolarity than when they were grown at low osmolarity and also showed increased extracellular activities when they were grown at high osmolarity. Finally, cells grown at high osmolarity showed better adhesion to HEp-2 cells than the same cells grown at low osmolarity, and furthermore the cells grown at high osmolarity were resistant to the bactericidal activity of nonimmune serum, while the same cells grown at low osmolarity were sensitive.