gebhart/patrepeval huggingface dataset:
Automate Minimization of Drive Tests for QoE Provisioning: The Case of Coverage Mapping (2015)

The concept of Minimization of Drive Tests (MDT) has been developed in Third Generation Partnership Project (3GPP) specifications standard. With MDT, Mobile Network Operators (MNOs) were enabled to remotely collect measurements indicating the network Quality of Service (QoS), as experienced by their users, correlated with actual location information. This results in wider application of use cases that allows network monitoring and optimization, without the need for conventional drive tests. To facilitate access to distributed geospatial data through a set of policies, common rules, and standards that would improve interoperability, this paper, proposes an open architecture, in compliance with the Open Geospatial Consortium (OGC) web services and the MDT architectures, enabling the automation of the MDT use cases and real-time service management.
Effects of Demineralized Dentin Matrix Used as an rhBMP-2 Carrier for Bone Regeneration (2014)

The purpose of this study was to evaluate the DDM as a carrier of recombinant human BMP-2 (rhBMP-2). In the study 1, the rhBMP-2 was fixed to inorganic bovine bones, tricalcium phosphate (TCP), DDM powder, and DDM chip. Over a period of 36 days, the amount of rhBMP-2 released was analyzed. In the study 2, the expression of protein markers by rhBMP-2 combined with DDM was evaluated in mice at 1, 2 and 4 weeks. In the control group (n=20 mice), 20 g grafts of TCP+rhBMP-2 (concentration=0.05 mg/ml) were applied, while in the experimental group (n=20 mice), 20 g grafts of DDM powder+rhBMP-2 (concentration=0.05 mg/ml) were applied. In the study 1, the slow release of rhBMP-2 was exhibited by all four graft types throughout the 36-day, a statistically significant large amount of rhBMP-2 was released from the DDM powder compared to the other materials (p<0.05). In the study 2, the expression of osteonectin was found to be limited to adjacent areas of TCP in the control group, however, it was observed in the DDM in the experimental group. The experimental group exhibited significant mature bone formation in the 4th week, but not in the 1st week of the experiment. Within limited research in this study DDM powder appears to have great potential as an effective scaffold for rhBMP-2. In the DDM powder+rhBMP-2, new bone formation was evidently shown and the amount of released rhBMP-2 was the highest. It was proposed that DDM powder might be an effective carrier of rhBMP-2.
The innervation of the bone marrow in laboratory animals (1968)

Abstract The nerve pattern of the bone marrow of the monkey, rabbit, rat and mouse was studied in serial sections specially stained to demonstrate myelinated and nonmyelinated nerve fibers. Features that are common to the different species studied were found in the bone marrow of the femur of the rat in a simple arrangement. A scheme is proposed based on thirteen photomicrographs demonstrating the nerve pattern of the bone marrow and the relation of the nerve fibers with the arterial tree, the sinusoids and the blood forming cells. This scheme shows that the necessary anatomical conditions exist permitting a direct influence of the nervous system on the function of the bone marrow. These conditions are the presence of myelinated nerve fibers traversing the parenchyma of the marrow, and the existence of nonmyelinated fibers ending in sphincterlike structures at the origin of the arterioles. Single myelinated nerve fibers and small bundles of both myelinated and nonmyelinated fibers lie in close contact with the endothelial wall of the sinuses during long trajects. Only the very thin endothelium of the sinuses separates the newly formed blood and the nerve fibers. An interaction between both elements is possible along these areas of contact.
Correlation Study of PtfV1 with Heart-Qi Deficiency Syndrome in Patients with Hypertensive Left Ventricular Hypertrophy (2002)

It is generally believed that the change of p-wave terminal force in lead V1 (PtfV1) is associated with the inner diameter of left atrium, left ventricular compliance,and ventricular diastolic function. The increase of negative value of PtfV1 in essential hypertensive (EH) patients with left ventricular hypertrophy (LVH) indicates the cardiac function may be damaged. In order to explore the relationship between Heart-Qi Deficiency Syndrome (HQDS) of TCM and PtfV1 level in hypertensive LVH patients, correlation analysis of scores of Heart-Qi Deficiency Syndrome and negative value of PtfV1 was made by the authors.
Drugs Active at T‐type Ca <sup>2+</sup> Channels (2006)

This chapter contains sections titled: Introduction Methodology Indications Conclusions
Protic Ionic Liquids and Salts as Versatile Carbon Precursors (2014)

Instead of traditional polymer precursors and complex procedures, easily prepared and widely obtainable nitrogen-containing protic ionic liquids and salts were explored as novel, small-molecule precursors to prepare carbon materials (CMs) via direct carbonization without other treatments. Depending on the precursor structure, the resultant CMs can be readily obtained with a relative yield of up to 95.3%, a high specific surface area of up to 1380 m(2)/g, or a high N content of up to 11.1 wt%, as well as a high degree of graphitization and high conductivity (even higher than that of graphite). One of the carbons, which possesses a high surface area and a high content of pyridinic N, exhibits excellent electrocatalytic activity toward the oxygen reduction reaction in an alkaline medium, as revealed by an onset potential, half-wave potential, and kinetic current density comparable to those of commercial 20 wt% Pt/C. These low-cost and versatile precursors are expected to be important building blocks for CMs.
Multiple effects and stimulation of insulin secretion by the tyrosine kinase inhibitor genistein in normal mouse islets (1995)

1. Islets from normal mice were used to test the acute effects of genistein, a potent tyrosine kinase inhibitor, on stimulus-secretion coupling in pancreatic beta-cells. 2. Genistein produced a concentration-dependent (10-100 microM), reversible, increase of insulin release. This effect was marginal on basal release or in the presence of non-metabolized secretagogues, and much larger in the presence of glucose or other nutrients. The increase in insulin release caused by 100 microM genistein was abolished by adrenaline or omission of extracellular Ca2+. It was not accompanied by any rise of cyclic AMP, inositol phosphate or adenine nucleotide levels. 3. Although genistein slightly inhibited ATP-sensitive K+ channels, as shown by 86Rb efflux and patch-clamp experiments, this effect could not explain the action of the drug on insulin release because the latter persisted when ATP-sensitive K+ channels were all blocked by maximally effective concentrations of glucose and tolbutamide. Genistein was also effective when ATP-sensitive K+ channels were opened by diazoxide and the beta-cell membrane depolarized by 30 mM K, but ineffective in the presence of diazoxide and normal extracellular K. 4. Genistein paradoxically decreased Ca2+ influx in beta-cells, as shown by the inhibition of glucose-induced electrical activity, by the inhibition of Ca2+ currents (perforated patches) and by the lowering of cytosolic [Ca2+]i (fura-2 technique). Genistein thus increases insulin release in spite of a lowering of [Ca2+]i in beta-cells. 5. Daidzein, an analogue of genistein reported not to affect tyrosine kinases, was slightly less potent than genistein on K+ and Ca2+ channels, but increased insulin secretion in a similar way. Three other tyrosine kinase inhibitors, tyrphostin A47, herbimycin A and an analogue of erbstatin variably affected insulin secretion.6. Genistein exerts a number of heretofore unrecognized effects. The unusual mechanisms, by which genistein increases insulin release in spite of a decrease in beta-cell [Ca2+]i and without activating known signalling pathways, do not seem to result from an inhibition of tyrosine kinases.
Ten vs Five Years of Bisphosphonate Treatment for Postmenopausal Osteoporosis (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
High frequency repeat-induced point mutation (RIP) is not associated with efficient recombination in Neurospora. (1994)

Duplicated DNA sequences in Neurospora crassa are efficiently detected and mutated during the sexual cycle by a process named repeat-induced point mutation (RIP). Linked, direct duplications have previously been shown to undergo both RIP and deletion at high frequency during premeiosis, suggesting a relationship between RIP and homologous recombination. We have investigated the relationship between RIP and recombination for an unlinked duplication and for both inverted and direct, linked duplications. RIP occurred at high frequency (42-100%) with all three types of duplications used in this study, yet recombination was infrequent. For both inverted and direct, linked duplications, recombination was observed, but at frequencies one to two orders of magnitude lower than RIP. For the unlinked duplication, no recombinants were seen in 900 progeny, indicating, at most, a recombination frequency nearly three orders of magnitude lower than the frequency of RIP. In a direct duplication, RIP and recombination were correlated, suggesting that these two processes are mechanistically associated or that one process provokes the other. Mutations due to RIP have previously been shown to occur outside the boundary of a linked, direct duplication, indicating that RIP might be able to inactivate genes located in single-copy sequences adjacent to a duplicated sequence. In this study, a single-copy gene located between elements of linked duplications was inactivated at moderate frequencies (12-14%). Sequence analysis demonstrated that RIP mutations had spread into these single-copy sequences at least 930 base pairs from the boundary of the duplication, and Southern analysis indicated that mutations had occurred at least 4 kilobases from the duplication boundary.
Rotating Machinery Diagnostics Using Deep Learning on Orbit Plot Images (2016)

Although the orbit analysis (orbit shape and size) is commonly used to diagnose rotating machinery, the diagnosis heavily depends on the expert knowledge or experience due to the difficulties of extracting mathematical features for data-driven approaches. Therefore, in this paper, we propose an autonomous orbit pattern recognition algorithm using the deep learning method on shaft orbit shape images. In details, the convolutional neural network is implemented to construct weights between neurons and to generate the entire structure of the neural network. Then, the created network enables us to classify fault modes of rotating machinery via orbit images. Furthermore, we demonstrate the proposed framework through a rotating testbed.
The different crystalline modifications of TiCl<sub>3</sub>, a catalyst component for the polymerization of α‐olefins. I: α‐, β‐, γ‐TiCl<sub>3</sub>. II: δ‐TiCl<sub>3</sub> (1961)

Abstract Crystalline TiCl 3 is the typical solid component of the catalytic system for the stereo‐specific polymerization of α‐olefins; hence a great interest in the knowledge of its crystal structure arises. Four different crystalline modifications of TiCl 3 (α, β, γ and δ) are known to date; three (β, γ, and δ) were first described in our laboratory. A preliminary structural distinction among them can be made in terms of fiber‐shaped (β) and layer (α, γ, and δ) modifications. The crystal structure of the β‐modification can, in fact, be considered as built up by linear macromolecules, while identical bidimensional (planar) macro molecules, packing with different sequences of shifts, between themselves, can originate an α‐, or γ‐, or δ‐TiCl 3 crystal. This close structural analogy explains the great similarity in physical and chemical properties of the last three modifications. In the first part of this paper, the most important structural features of α, β, and γ‐modifications are described; in the second, the structure of the most recently discovered δ‐TiCl 3 is more deeply analyzed. The presence of diffuse halos instead of sharp reflections in its Debye spectra clearly indicates the presence of a certain structural disorder; mathematical calculations (not fully reported here), based on the alternative assumption of two different statistical models of shift successions between structural layers, have led us to find the most probable succession type. As the possible shifts between adjacent structural layers cannot be different in type, in δ‐TiCl 3 , from those which take place in the ordered α‐ or γ‐modifications, we can say that, in δ‐TiCl 3 , the intervention of disorder in shift successions leads to something intermediate (in a statistical sense) between the two stated structures.
Crosstalk between pancreatic cancer cells and pancreatic cancer-associated fibroblasts through cytokines and a GPCR (2016)

Pancreatic cancer is the third leading cause of cancer death in the United States. Pancreatic ductal adenocarcinoma is the most prevalent type of pancreatic cancer and is characterized by dense fibrosis (termed desmoplasia) in the tumor microenvironment. Cancer associated fibroblasts (CAFs), which are thought to derive from pancreatic stellate cells (PSCs) and fibroblasts (PFs), play a large part in this desmoplasia. Signaling from cancer cells activates CAFs, which in turn can signal to promote tumorigenesis. Previous work done in the Insel lab had identified a GPCR, Orphan 1, as one of the most highly up-regulated GPCRs in CAFs compared to normal PSCs and PFs. This thesis project identifies TGFÎ² and TNFÎ± as factors that, increase, respectively, the expression in PSCs of fibrotic markers and Orphan 1. Other work in this project shows that Orphan 1 in CAFs regulates the expression and secretion of Interleukin-6 (IL-6). Orphan 1 signals through a Gs-coupled pathway (via cAMP and protein kinase A [PKA]) to increase IL-6 formation and secretion by CAFs; IL-6 can aid in the development of PDAC. Thus, inhibiting the secretion of IL-6 through Orphan 1 may be a novel strategy for the treatment of pancreatic cancer.
Pseudomembranous Tracheobronchitis Caused by <i>Aspergillus</i> (1991)

Four immunosuppressed patients with a rapidly evolving, febrile, respiratory distress syndrome were found at autopsy to have Aspergillus pseudomembranes of their lower tracheobronchial tree. Steroids, neutropenia, broad spectrum antibiotic use, and alcoholism appear to be predisposing risk factors. Bronchoscopy may reveal the pathology but antemortem diagnosis is difficult because of the low yield of sputum cultures and fulminant nature of the disease.
Effect of host responses on the pathogenicity of strains of <i>Porphyromonas gingivalis</i> (1996)

Porphyromonas gingivalis is implicated in the etiology of periodontitis. Strains of P. gingivalis have been classified as invasive or noninvasive based on their ability to form abscesses in a mouse model. The purpose of this study was to investigate the ability of P. gingivalis strains to cause abscesses and periodontal bone loss in an experimental rat model and the effect of serum and salivary responses on the pathogenicity of these strains. Subcutaneous injection of animals with P. gingivalis 33277, A7A1-28, W50 or 381 resulted in abscesses in a higher percentage of mice than rats. P. gingivalis 33277 caused lesions at the site of injection, whereas strains A7A1-28 and W50 induced abscesses at distant sites in both mice and rats. Local lesions were seen in rats injected with strain 381, whereas lesions formed distant from the site of injection in mice. When periodontal bone loss was assessed in the experimental rat model, animals challenged with 33277 had the highest amount of horizontal and vertical bone loss. Rats challenged with strain A7A1-28, W50 or 381 had some or no periodontal bone loss compared with controls. Assessment of antibody responses to P. gingivalis in these animals revealed that rats challenged with 33277 had lower levels of serum immunoglobulin G-(IgG) and especially salivary IgA antibody activity than A7A1-28-challenged rats. Serum IgG and in particular salivary IgA anti-P. gingivalis responses were seen in W50- and 381-challenged rats. These results indicate that the ability of P. gingivalis strains to cause abscesses does not relate directly to their periodontal pathogenicity as assessed by periodontal bone loss in the same animal model. The results further suggest the importance of salivary IgA antibody responses in protection against experimental periodontal bone loss after challenge with P. gingivalis.
Worldwide Emergence of Extensively Drug-resistant Tuberculosis (2007)

Mycobacterium tuberculosis strains that are resistant to an increasing number of second-line drugs used to treat multidrug-resistant tuberculosis (MDR TB) are becoming a threat to public health worldwide. We surveyed the Network of Supranational Reference Laboratories for M. tuberculosis isolates that were resistant to second-line anti-TB drugs during 2000-2004. We defined extensively drug-resistant TB (XDR TB) as MDR TB with further resistance to > or = 3 of the 6 classes of second-line drugs. Of 23 eligible laboratories, 14 (61%) contributed data on 17,690 isolates, which reflected drug susceptibility results from 48 countries. Of 3,520 (19.9%) MDR TB isolates, 347 (9.9%) met criteria for XDR TB. Further investigation of population-based trends and expanded efforts to prevent drug resistance and effectively treat patients with MDR TB are crucial for protection of public health and control of TB.
Equation-Based Model Data Structure for High Level Physical Modelling; Model Simplification and Modelica-Export (2011)

This paper proposes a novel data structure for equationbased plant models. The data structure facilitates the plant modelling process starting from physics-based component creation through model simplification to Modelica model export.
Bacteria-free solution derived from lactobacillus plantarum inhibits multiple NF-kappaB pathways and inhibits proteasome function (2009)

These studies confirm, and provide a mechanism for, the anti-inflammatory effects of the probiotic and commensal bacterium Lactobacillus plantarum. The use of bacteria-free Lp-CM provides a novel strategy for treatment of intestinal inflammation which would eliminate the risk of bacteremia reported with conventional probiotics.
COMBUSTION OF BIMODAL ALUMINUM PARTICLES AND ICE MIXTURES (2012)

The combustion of aluminum with ice is studied using various mixtures of nano- and micrometer-sized aluminum particles as a means to generate high-temperature hydrogen at fast rates for propulsion and power applications. Bimodal distributions are of interest in order to vary mixture packing densities and nascent alumina concentrations in the initial reactant mixture. In addition, the burning rate can be tailored by introducing various particle sizes. The effects of the bimodal distributions and equivalence ratio on ignition, combustion rates, and combustion efficiency are investigated in strand experiments at constant pressure and in small lab-scale [1.91 cm (0.75 in.) diameter] static fired-rocket-motor combustion chambers with center-perforated propellant grains. The aluminum particles consisted of nanometer-sized particles with a nominal diameter of 80 nm and micron-sized particles with nominal diameters of 2 and 5 µm. The micron particle addition ranged from 0% to 80% by active mass in the mixture. Burning rates from 1.1 (160 psia) to 14.2 MPa (2060 psia) were determined. From the small scale motor experiments, thrust, C*, Isp, and C* and Isp efficiencies are provided. From these results, mechanistic issues of the combustion process are discussed. In particular, overall lean equivalence ratios that produce flame temperatures near the melting point of alumina resulted in considerably lower experimental C* and Isp efficiencies than equivalence ratios closer to stoichiometric. The substitution of micron aluminum for nanometer aluminum had little effect on the linear burning rates of Al/ice mixtures for low-mass substitutions. However, as the mass addition of micron aluminum increased (e.g., beyond 40% 2-µm aluminum in place of 80-nm aluminum), the burning rates decreased. The effects of bimodal aluminum compositions on motor performance were minor, although the experimental results suggest longer combustion times are necessary for complete combustion.
Integrated Design-Stage Failure Analysis of Software-Driven Hardware Systems (2010)

Software-driven hardware configurations account for the majority of modern safety-critical complex systems. The often costly failures of such systems can be attributed to software specific, hardware specific, or software/hardware interaction failures. The understanding of how failures propagate in such complex systems might provide critical information to designers, because, while a software component may not fail in terms of loss of function, a software operational state can cause an associated hardware failure. The least expensive phase of the product life cycle to address failures is during the design stage. This research presents a means to evaluate how a combined software/hardware system behaves and how such failures propagate to result in potential failures downstream, during the conceptual design stage. In particular, this paper proposes the use of high-level system modeling and model-based reasoning approaches to model failure propagation in combined software-hardware systems, introducing the Function-Failure Identification and Propagation (FFIP) analysis framework to help formalize the design of safety-critical systems. The fact that the hardware and software designers do not share the same background, knowledge, methods, or language contributes significantly to software/hardware interaction failures. A high-level systems analysis method, such as FFIP, is geared toward the unification of language and modeling concepts and may help to more seamlessly bridge such a gap. The technique is applied to the design of the Reaction Control System Jet Selection of the NASA space shuttle to evaluate failure propagation within the Reaction Control System Jet selection, specifically for the redundancy management system. The paper concludes with the extensions and mappings to the software domain that are required for a truly integrated methodology.
Self-Configuration of Spontaneous Networks by Context-Aware Mechanisms (2009)

Ad-hoc network management differs from that carried out in networks with infrastructure in that a central node is not used to undertake tasks. Spontaneous networks may be the solution to the configuration problems posed. Here we present a distribution model to resolve these questions.