gebhart/patrepeval huggingface dataset:
Regulation of Progesterone Receptor Messenger Ribonucleic Acid in the Rat Medial Preoptic Nucleus by Estrogenic and Antiestrogenic Compounds: An<i>in Situ</i>Hybridization Study (1997)

Progesterone receptor (PR) messenger RNA (mRNA) is concentrated in neurons of the preoptic area and other regions of the rat hypothalamus where it is colocalized with the estrogen receptor and regulated by changes in the steroid hormonal milieu. To date, little is known about the regulation of PR mRNA by estrogens and whether antiestrogenic compounds are capable of modulating its expression. The present studies used in situ hybridization to ascertain the time course of PR mRNA regulation in the medial preoptic nucleus by 17beta-estradiol, determine the effective dose required to elicit a response, and compare the efficacy of 17beta-estradiol with a variety of estrogenic or antiestrogenic compounds. The first series of studies revealed that the treatment of ovariectomized rats with 17beta-estradiol resulted in an increase in PR expression within 2 h, after which it remained elevated until 10 h postinjection and then returned to baseline levels. When ovariectomized rats were injected with 25-1000 ng/kg of 17beta-estradiol and euthanized 6 h later, a dose-dependent increase in the level of PR mRNA was observed, with a maximal response at 1000 ng/kg and an EC50 of 93.5 ng/kg. Subsequent studies evaluated the efficacy of a variety of estrogenic and antiestrogenic compounds in the rat preoptic nucleus. 17Beta-estradiol, diethylstilbestrol, and 17alpha-estradiol all significantly increased the level of PR mRNA, although the degree of induction varied with each compound. The injection of tamoxifen, raloxifene, toremifene, droloxifene, clomiphene, GW 5638, or ICI 182,780 had no significant estrogenic effect on PR gene expression at the dose evaluated. In contrast, when tamoxifen or raloxifene, but not ICI 182,780, was administered in the antagonist mode, a significant dose-related decrease in the estradiol-induced level of PR mRNA was seen in the preoptic area. The results of these studies clearly demonstrate that PR mRNA expression in the rat preoptic area is rapidly stimulated by a small dose of 17beta-estradiol. Moreover, the present report has also shown that the estrogenic nature of compounds such as tamoxifen, raloxifene, toremifene, droloxifene, clomiphene, and GW 5638 cannot be predicted by their activity in peripheral tissues. Together, the results of these studies provide important information about the central activity of estrogens and provide evidence for their tissue-specifc actions in the rat.
Monte Carlo simulations of spin-1/2 micelle and microemulsion models (1988)

The Widom model of microemulsions is defined by a spin-1/2 Ising simple cubic lattice with ferromagnetic nearest neighbor interactions, antiferromagnetic next-nearest neighbor interactions and half as strong antiferromagnetic interactions at distance = 2. We compare the mean-field predictions of the Widom group with our Monte Carlo simulations of the phase diagram and interfaces. One of the predicted phases is shown to be unstable, and in another the transition temperature differs by a factor 3. Other mean field predictions are in good agreement with our simulations. For the interface with amphiphilic molecules in between oil and water large widths are observed for higher temperatures, and the interface energy vanishes at the stability limit of the ferromagnetic phase at low temperatures, as is required for an appropriate description of microemulsions. Large clusters are found if the numbers of molecules, instead of their chemical potentials, are kept constant in the simulation. We also check Shnidman's predictions for a different model of binary micellar solutions and find that this model also leads to complex phases.
A Practical Approach to Intensive German (1973)

fourth-year language courses with a view toward bringing them into harmony with our lower-division program. We are particularly interested in attracting non-majors into our more advanced courses. For those uninterested in literature as well as for those who want not only literature, but who also want to improve their language skills, we have introduced three-hour basic courses on contemporary Germany, Austria and Switzerland, in which we make extensive use of newspapers and magazines. As an added incentive to students to sign up for these courses, we do not consider the four semesters to be sequential. We do require, however, at least three hours at the third-year level for admittance into either of the fourth-year courses. We are also trying to staff these courses so that each is taught by a different instructor. These four basic courses may be supplemented or replaced by two courses open to both juniors and seniors: one dealing with films and their texts, the other with German music and art. These courses also have as one of their principal goals the development of language skills. Small conversation groups are also available to students on the advanced level.
SIFT feature-preserving bit allocation for H.264/AVC video compression (2012)

Compression artifacts in low-quality videos strongly influence the performance of feature matching algorithms. In order to achieve reasonable feature matching performance even for low bit rate video, we propose to allocate the bit budget during compression such that the important features are preserved. Specifically, we present two bit allocation approaches to preserve the strongest SIFT features for H.264 encoded videos. For both approaches, we first categorize the Macroblocks in a Group of Pictures into several groups according to the scale specific characteristics of SIFT features. In our first approach a novel R-D model based on the matching score is applied to allocate the bit budget to these groups. In our second approach, in order to reduce the computational complexity, we analyze the detector characteristics of correctly matched pairs and propose a R-D optimization method based on the repeatability metric. Our experiments show that both approaches achieve better feature preservation when compared to standard video encoding which is optimized for maximum picture quality. The proposed approaches are fully standard compatible and the encoded videos can be decoded by any H.264 decoder.
A Bayesian approach to determining and parametrizing earthquake focal mechanisms (2008)

We develop a new probabilistic (Bayesian) method for estimating the distribution of focal mechanism parameters, based on seismic-wave polarity data. We investigate the use of generalized Matrix Fisher distributions for parametrizing focal mechanism uncertainties. The advantages of our approach are that it (1) models the data generation process and incorporates observational errors, particularly those arising from imperfectly known earthquake locations; (2) allows exploration of the entire parameter space; (3) leads to natural point estimates of focal mechanism parameters; (4) allows the inclusion of a priori information about the focal mechanism parameters and (5) allows the resulting posterior PDF to be well approximated by generalized Matrix Fisher distributions. We present here the results of our method in two situations. We first consider the case in which the seismic velocity of the region of interest (described by a velocity model) is presumed to be precisely known, with application to seismic data from the Raukumara Peninsula, New Zealand. We then consider the case in which the velocity model is imperfectly known, with application to data from the Kawerau region, New Zealand. We find that our estimated focal mechanism solutions are for the most part consistent with all available polarity data and correspond closely to solutions obtained using established methods. Further, the generalized Matrix Fisher distributions we examine provide a good fit to our Bayesian posterior PDF of the focal mechanism parameters. Finally, we demonstrate how informative prior distributions on focal mechanism parameters can be incorporated into our model.
Homotaurine Effects on Hippocampal Volume Loss and Episodic Memory in Amnestic Mild Cognitive Impairment (2016)

Homotaurine supplementation may have a positive effect on early Alzheimer's disease. Here, we investigated its potential neuroprotective effect on the hippocampus structure and episodic memory performances in amnestic mild cognitive impairment (aMCI). Neuropsychological, clinical, and neuroimaging assessment in 11 treated and 22 untreated patients were performed at baseline and after 1 year. Magnetic resonance data were analyzed using voxel-based morphometry to explore significant differences (Family Wise Error corrected) between the two groups over time. Patients treated with homotaurine showed decreased volume loss in the left and right hippocampal tail, left and right fusiform gyrus, and right inferior temporal cortex which was associated with improved short-term episodic memory performance as measured by the recency effect of the Rey 15-word list learning test immediate recall. Thus, homotaurine supplementation in individuals with aMCI has a positive effect on hippocampus atrophy and episodic memory loss. Future studies should further clarify the mechanisms of its effects on brain morphometry.
Scalable WDM access network architecture based on photonic slot routing (1999)

This paper introduces an approach to solving the fundamental scalability problem of all-optical packet switching wavelength-division multiplexing (WDM) access networks. Current optical networks cannot be scaled by simply adding nodes to existing systems due to the accumulation of insertion losses and/or the limited number of wavelengths. Scalability through bridging requires, on the other hand, the capability to switch packets among adjacent subnetworks on a wavelength basis. Such a solution is, however, not possible due to the unavailability of fast-switching wavelength sensitive devices. In this paper, we propose a scalable WDM access network architecture based on a recently proposed optical switching approach, termed photonic slot routing. According to this approach, entire slots, each carrying multiple packets (one on each wavelength) are "transparently" routed through the network as single units so that wavelength sensitive data flows can be handled using fast-switching wavelength nonsensitive devices based on proven technologies. The paper shows that the photonic slot routing technique can be successfully used to achieve statistical multiplexing of the optical bandwidth in the access network, thus providing a cost-effective solution to today's increasing bandwidth demand for data transmissions.
2.5-Dimensional Parylene C micropore array with a large area and a high porosity for high-throughput particle and cell separation (2018)

Large-area micropore arrays with a high porosity are in high demand because of their promising potential in liquid biopsy with a large volume of clinical sample. However, a micropore array with a large area and a high porosity faces a serious mechanical strength challenge. The filtration membrane may undergo large deformation at a high filtration throughput, which will decrease its size separation accuracy. In this work, a keyhole-free Parylene molding process has been developed to prepare a large (>20 mm × 20 mm) filtration membrane containing a 2.5-dimensional (2.5D) micropore array with an ultra-high porosity (up to 91.37% with designed pore diameter/space of 100 μm/4 μm). The notation 2.5D indicates that the large area and the relatively small thickness (approximately 10 μm) of the fabricated membranes represent 2D properties, while the large thickness-to-width ratio (10 μm/ < 4 μm) of the spaces between the adjacent pores corresponds to a local 3D feature. The large area and high porosity of the micropore array achieved filtration with a throughput up to 180 mL/min (PBS solution) simply driven by gravity. Meanwhile, the high mechanical strength, benefiting from the 2.5D structure of the micropore array, ensured a negligible pore size variation during the high-throughput filtration, thereby enabling high size resolution separation, which was proven by single-layer and multi-layer filtrations for particle separation. Furthermore, as a preliminary demonstration, the prepared 2.5-dimensional Parylene C micropore array was implemented as an efficient filter for rare cancer cell separation from a large volume, approximately 10 cells in 10 mL PBS and undiluted urine, with high recovery rates of 87 ± 13% and 56 ± 13%, respectively.
Speedup of deep neural network learning on the MIC-architecture (2016)

Deep neural networks are more accurate, but require more computational power in the learning process. Moreover, it is an iterative process. The goal of the research is to investigate efficiency of solving this problem on MIC architecture without changing baseline algorithm. Well-known code vectorization and parallelization methods are used to increase the effectiveness of the program on MIC architecture. In the course of the experiments we test two coprocessor data transfer models: explicit and implicit one. We show that implicit memory copying is more efficient than explicit one, because only modified memory blocks are copied. MIC architecture shows competitive performance compared to multi-core ×86 processor.
Unusual Cause of Anuria in a Transplant Patient (1977)

No AccessJournal of Urology1 Jan 1977Unusual Cause of Anuria in a Transplant Patient Martin G. Mcloughlin Martin G. McloughlinMartin G. Mcloughlin More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)58368-8AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail A case is described of a pregnant renal allograft recipient, near full-term, who presented with a sudden onset of anuria accompanied by azotemia. © 1977 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited BySelman S, Grecos G and Koo B (2018) Anuria in Transplant Patient Following Inguinal HerniorrhaphyJournal of Urology, VOL. 133, NO. 4, (669-670), Online publication date: 1-Apr-1985. Volume 117Issue 1January 1977Page: 124 Advertisement Copyright & Permissions© 1977 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Martin G. Mcloughlin More articles by this author Expand All Advertisement PDF DownloadLoading ...
rRNA Chemical Groups Required for Aminoglycoside Binding (1998)

Through an affinity chromatography based modification-interference assay, we have identified chemical groups within Escherichia coli 16S ribosomal RNA sequence that are required for binding the aminoglycoside antibiotic paromomycin. Paromomycin was covalently linked to solid support via a nine atom spacer from the 6"'-amine of ring IV, and chemical modifications to an A-site oligonucleotide that disrupted binding were identified. Positions in the RNA oligonucleotide that correspond to G1405(N7), G1491(N7), G1494(N7), A1408(N7), A1493(N7), A1408(N1), A1492(N1), and A1493(N1), as well as the pro-R phosphate oxygens of A1492 and A1493 in 16S rRNA are chemical groups that are essential for a high-affinity RNA-paromomycin interaction. These data are consistent with genetic, biochemical, and structural studies related to neomycin-class antibiotics and provide additional information for establishing an exact model for their interaction with the ribosome.
Seismic-Based Personnel Detection (2007)

The U.S. Army's Engineer Research and Development Center - Cold Regions Research and Engineering Laboratory is investigating the feasibility of seismic-based personnel detection in non-traditional applications. A detection algorithm specific to footstep- induced ground motion has been tested against field data representing pedestrian and vehicle movement. Detection ranges greater than those of commercial systems and discrimination against vehicle-induced ground motion have been realized. Details of the algorithm performance, progress in the development of a personnel detection system, tactics for its use in seismically cluttered environments, and deployment guidance for incorporating seismic personnel detection in security designs are presented.
<sup>111</sup>In for Imaging: Lymph Node Visualization (1970)

A new radiocolloid of 111In has optimum physical characteristics for the study of lymphatics using the Anger gamma camera. For observations one to three days following injection, the half-life of 111In allows excellent counting statistics with minimum patient radiation dose. 111In was injected subcutaneously in the dog and was distributed primarily in the injection site, regional lymph nodes, and the liver via the systemic veins. Following intravenous injection in white mice 111In was concentrated in the liver and spleen, and virtually no activity was recovered from the blood, kidneys, or lungs.
Human T cell clones recognize two abundant <i>Mycobacterium tuberculosis</i> protein antigens expressed in <i>Escherichia</i> coli. (1987)

Human T cells reactive to Mycobacterium tuberculosis were cloned from peripheral blood mononuclear cells (PBMC) of four tuberculosis patients by using whole irradiated bacilli as the in vitro stimulatory agent. Twenty-two T cell clones (CD4+) were tested for their reactivity to 12 different mycobacterial species and showed a distribution from limited to broad cross-reactivity. These T cell clones were also tested for their reactivity to three abundant M. tuberculosis proteins of 65, 19, and 14 kD, each expressed from recombinant DNA in Escherichia coli. The three proteins were expressed from DNA clones that were previously isolated from a lambda gt11 genomic DNA library of M. tuberculosis by using monoclonal antibodies directed against this pathogen. A T cell clone from one patient was stimulated by an E. coli lysate containing the 65 kD antigen, and a T cell clone from a second patient was stimulated by an E. coli lysate containing the 19 kD antigen in an in vitro proliferation assay. Both T cell clones showed very limited cross-reactivity when tested against other mycobacteria. We conclude that some patients with tuberculosis exhibit a T cell response to the 65 and 19 kD M. tuberculosis proteins defined by these isolated genes.
Der katalytische enantioselektive Aufbau von Molekülen mit quartären Kohlenstoff-Stereozentren (1998)

Scheinbar wie durch Magie können komplexe chirale Moleküle mit quartären Stereozentren aus achiralen Bausteinen zusammengesetzt werden, indem eine Vielzahl neuer und effektiver katalytischer asymmetrischer Reaktionen angewendet wird. Die unten gezeigte Reaktionsfolge gibt ein Beispiel.
Extracting oscillometric pulses from the cuff pressure: does it affect the pressures determined by oscillometric blood pressure monitors? (2006)

The filter alters the shape of oscillometric pulses causing a shift in the oscillometric pulse amplitude envelope drawn from the filtered pulses compared with that drawn from the unfiltered pulses in human subjects, but not the test simulator. The pulse shape distortion is dependent on the filter characteristics and the oscillometric pulse shape. Further work is required to explore whether this may help explain why simulators with artificial waveforms cannot validate noninvasive blood pressure monitors and why noninvasive blood pressure monitors may not be accurate in all patient groups.
Cloning and Functional Analysis of GmNF-YC2 Gene in Soybean (Glycine max) (2012)

摘要： NF-Y (nuclear factor-y)是真核生物中普遍存在的一种转录因子复合物, 是由3个不同的亚基(A, B, C)组成, 并通过作用于其他调控因子的启动子来调节目的基因的表达。本文从大豆KN18中克隆大豆NF-YC基因GmNF-YC2, 并且利用实时荧光定量PCR (qRT-PCR)分析其表达模式, 发现GmNF-YC2的表达受光调控, 并在开花期第3复叶中表达量最高。结果表明, GmNF-YC2在大豆光周期开花调节中起重要作用。拟南芥原生质体瞬时表达实验证实, GmNF-YC2蛋白定位在细胞核中。这为大豆NF-YC家族基因的功能研究提供重要依据。
Complex Phase Behavior in Solvent-Free Nonionic Surfactants (1996)

Unsolvated block copolymers and surfactant solutions are “soft materials” that share a common set of ordered microstructures. A set of polyethyleneoxide-polyethylethylene (PEO-PEE) block copolymers that are chemically similar to the well-known alkane-oxyethylene (C n EO m ) nonionic surfactants was synthesized here. The general phase behavior in these materials resembles that of both higher molecular weight block copolymers and lower molecular weight nonionic surfactant solutions. Two of the block copolymers exhibited thermally induced order-order transitions and were studied in detail by small-angle scattering. The fundamental microstructural spacing was determined to be a crucial parameter in these transitions. Transitions from one ordered state to another occur only when the lattice spacing is nearly matched. These materials highlight the importance of epitaxy and molecular conformation in the phase transformations of soft material.
High prices may hinder widespread use of needles with new safety features. (1990)

Needlestick injuries are getting attention now that hospital liability for blood-borne diseases is a hot topic. But safer needle devices and alternatives to needles have yet to catch on, held down by high price and uncertain demand.
Bottom antireflective coatings for ArF, KrF, and i-line applications: a comparison of theory, design, and lithographic aspects (1999)

The present paper discusses theory, design and properties of bottom anti-reflective coatings (BARCs) for deep UV and i- line applications. All BARCs are interference devices, and as such their optical constants are optimal only for certain combinations of thickness and the real and imaginary parts of the refractive index. Maps of the optimality conditions in the parameter space will be provided. The design of BARCs for various exposure wavelengths involves choosing the right dye molecules capable of highly absorbing at the particular wavelengths and optimizing the etch rates of the resulting film sand fine tuning the formations for best lithographic performance. At an exposure wavelength of 365 nm, dye compounds such as amino aromatic or azo type compounds can be used, for 248 nm it is necessary to use fused rings such as anthracene to have sufficient absorption, and in the case of 193 nm exposures simple benzene or phenolic compounds exhibit the required d absorbance. Since the dye molecules are invariably aromatic or fused rings, it is necessary to balance the absorption property versus the etch rate by incorporating non-aromatic moieties. Further, the BARC formulations need to be free from intermixing, formation of foot or undercut in order to obtain fine resist patterns. Our development efforts on BARCs have led to the AZ EXP ArF, KrF and BARLi series of BARCs designed for 193, 248 and 365 nm wavelength exposures, respectively. Lithographic data of some of these products will also be presented with the emphasis on the AZ EXP ArF-1 material designed for 193 nm exposure.
Solar absorption by atmospheric water vapor: a comparison of radiation models (1985)

We have intercompared several different procedures for evaluating solar absorption by atmospheric water vapor, and in particular we have employed a random band model as a diagnostic tool for assessing approximations which are inherent in existing parameterizations. We reaffirm McDonald’s (1960) conclusion as to the importance of the 0.72 and 0.81 μm water vapor absorption bands, and we find that the Goody random band model and the Lacis-Hansen empirical parameterization produce comparable tropospheric heating rates. This agreement does not extend to the stratosphere. for which water vapor amounts lie outside the intended range of applicability of the Lacis-Hansen parameterization. But when diurnal averaging is taken into account, the disagreement is reduced. We further present what is in effect a two-parameter extension of the Lacis-Hansen parameterization.
Nível de infestação de Butiobruchus sp em amêndoas de butiazeiro (1995)

As sementes do butiazeiro, Butia capitata (Martius) Beccari, são atacadas por um caruncho, Butiobruchus sp. Menos de 80% das larvas originam adultos. A maioria das larvas destrói apenas uma amêndoa. O bruquídeo não é fator limitante para a sobrevivência desta palmeira.