gebhart/patrepeval huggingface dataset:
Human Cytomegalovirus Antigens in Malignant Gliomas as Targets for Adoptive Cellular Therapy (2014)

Malignant gliomas are the most common primary brain tumor in adults, with over 12,000 new cases diagnosed in the United States each year. Over the last decade, investigators have reliably identified human cytomegalovirus (HCMV) proteins, nucleic acids, and virions in most high-grade gliomas, including glioblastoma (GBM). This discovery is significant because HCMV gene products can be targeted by immune-based therapies. In this review, we describe the current level of understanding regarding the presence and role in pathogenesis of HCMV in GBM. We describe our success detecting and expanding HCMV-specific cytotoxic T lymphocytes to kill GBM cells and explain how these cells can be used as a platform for enhanced cellular therapies. We discuss alternative approaches that capitalize on HCMV infection to treat patients with HCMV-positive tumors. Adoptive cellular therapy for HCMV-positive GBM has been tried in a small number of patients with some benefit, but we reason why, to date, these approaches generally fail to generate long-term remission or cure. We conjecture how cellular therapy for GBM can be improved and describe the barriers that must be overcome to cure these patients.
<title>Map-Matching Techniques For Terminal Guidance Using Fourier Phase Information</title> (1979)

The application of Lockheed's phase correlation image matching technique to missile guidance has been sys-tematically investigated during the past several years. An effective approach to the scene distortion problem has been developed and verified for a variety of sensor types by computer simulation. The method involves the computation of a full bandwidth Fourier phase difference matrix for the reference and sensed scenes to be matched, followed by the application of the inverse Fourier transform to the phase matrix modified by a series of bandwidth-reducing filters to produce a set of trial correlation functions. The "best" matchpoint is then selected using parameters derived from each correlation function. A novel method for onboard reference map storage has been developed using quantized Fourier phase angles.
The lncRNA <i>PCAT29</i> Inhibits Oncogenic Phenotypes in Prostate Cancer (2014)

This study identifies PCAT29 as the first androgen receptor-repressed lncRNA that functions as a tumor suppressor and that its loss may identify a subset of patients at higher risk for disease recurrence. Visual Overview: http://mcr.aacrjournals.org/content/early/2014/07/31/1541-7786.MCR-14-0257/F1.large.jpg.
Effect of fit adjustment on CEREC CAD-CAM veneers. (1997)

Three-way ANOVA disclosed that fit adjustment was relatively ineffective (P approximately 0.05), but that measurement section location, measurement point location and their interaction significantly affected fit (P < 0.05). Restoration of the broken proximal contact, or simulated diastema closure did not compromise fit. Incisal margins ranked worst for fit. Surface measurement point locations ranked worse than internal points. The fit of these CEREC CAD-CAM veneers was not substantially different from previously published fit values for conventional porcelain veneers.
THE EFFECT OF ESTROGEN ON THE PRODUCTION OF A PEROXIDASE IN THE RAT UTERUS (1955)

McShan and Meyer (1) observed an inhibition of the succinoxidase system of rat liver homogenate upon the addition of a small amount of diethylstilbestrol, hexestrol, and dienestrol.The locus of inhibition was considered to be cytochrome oxidase.Case and Dickens (2) amplified these observations by investigating a wider range of estrogens and chemically related compounds of slight estrogenic potency.The inhibition in vitro of the succinoxidase system by these compounds was found not to be correlated with estrogenic potency and the site of inhibition was not the same with the different estrogens studied.Hochster and Quastel (3) reported that oxidized diethylstilbestrol could act as a hydrogen acceptor in certain enzyme systems.In view of these findings and since this laboratory has been engaged in the separation and study of the "individual" components of the succinoxidase system (4-7), it was of interest to investigate the various components of the succinoxidase system in the rat uterus following stimulation with estrogen.During the course of this study, it was found that the injection of estrogens into the ovariectomized rat caused a pronounced activity of peroxidase in the uterus, whereas this activity was normally extremely low.Further, the peroxidase activity was related to the amount of estrogen injected. MethodsFemale rats of the Wistar strain, weighing from 180 to 200 gm., were ovariectomized under aseptic conditions.4 weeks after ovariectomy the animals were injected intramuscularly with 0.2 ml. of cottonseed oil for controls or with 0.2 ml. of a cottonseed oil solution of estrogen.The amounts of diethylstilbestrol or 17p-estradiol used for injection were 0.05, 0.10, 0.20, 0.30 mg.The rats were sacrificed by decapitation at intervals of up to 4 days after injection of the hormone.The uterus of each animal was quickly removed, stripped of visible fat, and chilled.The uteri of three rats were pooled and 20 per cent homogenates in cold 0.1 M NazHP04-KH2P04 buffer, pH 7.4, were prepared in a chilled all-glass homogenizer.
Building End-To-End Dialogue Systems Using Generative Hierarchical Neural Network Models (2016)

We investigate the task of building open domain, conversational dialogue systems based on large dialogue corpora using generative models. Generative models produce system responses that are autonomously generated word-by-word, opening up the possibility for realistic, flexible interactions. In support of this goal, we extend the recently proposed hierarchical recurrent encoder-decoder neural network to the dialogue domain, and demonstrate that this model is competitive with state-of-the-art neural language models and back-off n-gram models. We investigate the limitations of this and similar approaches, and show how its performance can be improved by bootstrapping the learning from a larger question-answer pair corpus and from pretrained word embeddings.
Chronic Parkinsonism Associated With Cirrhosis (2003)

Cirrhosis-related parkinsonism may represent a unique, consistent, and common subset of acquired hepatocerebral degeneration, whose features are permanent and entirely different from acute hepatic encephalopathy episodes. This form of parkinsonism can be clearly distinguished from other forms of parkinsonism of middle to advanced age, based on a suggestive association of clinical, neuroradiological, and biological abnormalities. Our findings support the concept of the toxic effects of manganese being the major determinant of basal ganglia dysfunction leading to the predominantly extrapyramidal central nervous system manifestations of cirrhosis observed in these patients.
A randomized comparison of 4 courses of standard-dose multiagent chemotherapy versus 3 courses of high-dose cytarabine alone in postremission therapy for acute myeloid leukemia in adults: the JALSG AML201 Study (2010)

We conducted a prospective randomized study to assess the optimal postremission therapy for adult acute myeloid leukemia in patients younger than 65 years in the first complete remission. A total of 781 patients in complete remission were randomly assigned to receive consolidation chemotherapy of either 3 courses of high-dose cytarabine (HiDAC, 2 g/m(2) twice daily for 5 days) alone or 4 courses of conventional standard-dose multiagent chemotherapy (CT) established in the previous JALSG AML97 study. Five-year disease-free survival was 43% for the HiDAC group and 39% for the multiagent CT group (P = .724), and 5-year overall survival was 58% and 56%, respectively (P = .954). Among the favorable cytogenetic risk group (n = 218), 5-year disease-free survival was 57% for HiDAC and 39% for multiagent CT (P = .050), and 5-year overall survival was 75% and 66%, respectively (P = .174). In the HiDAC group, the nadir of leukocyte counts was lower, and the duration of leukocyte less than 1.0 × 10(9)/L longer, and the frequency of documented infections higher. The present study demonstrated that the multiagent CT regimen is as effective as our HiDAC regimen for consolidation. Our HiDAC regimen resulted in a beneficial effect on disease-free survival only in the favorable cytogenetic leukemia group. This trial was registered at www.umin.ac.jp/ctr/ as #C000000157.
Second harmonic generation in electric poled X-cut MgO-doped LiNbO3 waveguides (1997)

We demonstrate that quasi-phase-matched second harmonic generation occurs in annealed proton-exchanged (APE) X-cut MgO 5 mol % doped LiNbO3 (MgO:LN) waveguides supporting a TE-mode guided wave. Formation of a domain inversion was achieved by applying electric fields in X-cut and Y-cut MgO:LN. The depth of the formed domain inversion was 1 μm with a period of 4.75 μm. Anomalous characteristics of current versus voltage (I–V) of samples having domain inversion formed therein were found to have similar properties to a diode. A blue light having a wavelength of 475 nm and a power of 2.2 mW has been obtained with a normalized second harmonic conversion efficiency of 60%/W cm2 with uniform grating of 6 mm by using a Ti:Al2O3 laser as a fundamental wave source.
Fundamental matrix from optical flow: optimal computation and reliability evaluation (2000)

The <i>Journal of Electronic Imaging</i> (JEI), copublished bimonthly with the Society for Imaging Science and Technology, publishes peer-reviewed papers that cover research and applications in all areas of electronic imaging science and technology.
Generate Nyquist-WDM Signal Using a DAC With Zero-Order Holding at the Symbol Rate (2014)

We demonstrate the Nyquist spectral shaping using a two-channel interleaved DAC with zero-order holding at the speed of the symbol rate, and investigate the required spectral preemphasis, bandwidth, and resolution. Compared to a conventional DAC at a speed of two times the symbol rate, we find that an extra spectral preemphasis is required for compensating the extra spectral roll-off in the two-channel interleaved DAC. The spectral preemphasis can facilitate Nyquist spectrally shaped signals generation with negligible OSNR penalty (<;0.1 dB). With proper spectral preemphasis, both the required electrical filter bandwidth and DAC resolution are similar to those with a conventional DAC used. To obtain <;0.1 dB OSNR penalty for root-raised-cosine Nyquist spectrally shaped WDM systems with a roll-off factor of 0.1 and a spectral shaping FIR filter tap number of 37, the two-channel interleaved DAC needs a Gaussian electrical filter with the bandwidth between 0.3 and 0.8 times of the symbol rate for PDM-QPSK signal, and between 0.35 and 0.65 times of the symbol rate for PDM-16QAM signal. Meanwhile, the required DAC resolutions are 6 bits and 7 bits for PDM-QPSK and PMD-16QAM, respectively. We also demonstrate how a polyphase FIR filter structure is applied in the transmitter to reduce the calculation by half and to increase the processing parallelism.
High-Frequency Motility of Outer Hair Cells and the Cochlear Amplifier (1995)

Outer hair cells undergo somatic elongation-contraction cycles in vitro when electrically stimulated. This "electromotile" response is assumed to underlie the high sensitivity and frequency selectivity of amplification in the mammalian cochlea. This process, presumably operating on a cycle-by-cycle basis at the frequency of the stimulus, is believed to provide mechanical feedback in vivo. However, if driven by the receptor potential of the cell, the mechanical feedback is expected to be severely attenuated at high frequencies because of electrical low-pass filtering by the outer hair cell basolateral membrane. It is proposed that electromotility at high frequencies is driven instead by extracellular potential gradients across the hair cell, and it is shown that this driving voltage is not subject to low-pass filtering and is sufficiently large. It is further shown that if the filtering properties of the cell membrane are canceled, taking advantage of the electrical characteristics of isolated outer hair cells in a partitioning glass microchamber, then the lower bound of the motor's bandwidth is approximately 22 kilohertz, a number determined only by the limitations of our instrumentation.
3D Video Recorder: a System for Recording and Playing Free‐Viewpoint Video<sup>†</sup> (2003)

Abstract We present the 3D Video Recorder, a system capable of recording, processing, and playing three‐dimensional video from multiple points of view. We first record 2D video streams from several synchronized digital video cameras and store pre‐processed images to disk. An off‐line processing stage converts these images into a time‐varying 3D hierarchical point‐based data structure and stores this 3D video to disk. We show how we can trade‐off 3D video quality with processing performance and devise efficient compression and coding schemes for our novel 3D video representation. A typical sequence is encoded at less than 7 Mbps at a frame rate of 8.5 frames per second. The 3D video player decodes and renders 3D videos from hard‐disk in real‐time, providing interaction features known from common video cassette recorders, like variable‐speed forward and reverse, and slow motion. 3D video playback can be enhanced with novel 3D video effects such as freeze‐and‐rotate and arbitrary scaling. The player builds upon point‐based rendering techniques and is thus capable of rendering high‐quality images in real‐time. Finally, we demonstrate the 3D Video Recorder on multiple real‐life video sequences. ACM CSS: I.3.2 Computer Graphics— Graphics Systems , I.3.5 Computer Graphics— Computational Geometry and Object Modelling , I.3.7 Computer Graphics— Three‐Dimensional Graphics and Realism
Hydrogen Peroxide (2001)

Abstract Hydrogen peroxide is a strong oxidizing agent commercially available in aqueous solution over a wide concentration range. Its many uses involve its varied chemistry and are based on oxidations, reductions, substitutions, molecular additions, and decompositions. Product from hydrogen peroxide decomposition are the environmentally benign oxygen and water. Manufacture and use, especially in industrial bleaching applications, are on the rise, fueled by environmental concerns and econological pressure to replace chlorine‐based bleaching with the cleaner peroxide chemistry. Manufactured primarily in large, strategically located anthrahydroquinone autoxidation processes, the primary use for hydrogen peroxide is in bleaching wood pulp. Hydrogen peroxide is also produced electrolytically. The various manufacturing processes are discussed. Safe use and handling require adherence to approved procedures and use of proper protective equipment.
Analysis of Human Immunodeficiency Virus Type 1 Viremia and Provirus in Resting CD4 <sup>+</sup> T Cells Reveals a Novel Source of Residual Viremia in Patients on Antiretroviral Therapy (2009)

Highly active antiretroviral therapy (HAART) can reduce human immunodeficiency virus type 1 (HIV-1) viremia to clinically undetectable levels. Despite this dramatic reduction, some virus is present in the blood. In addition, a long-lived latent reservoir for HIV-1 exists in resting memory CD4(+) T cells. This reservoir is believed to be a source of the residual viremia and is the focus of eradication efforts. Here, we use two measures of population structure--analysis of molecular variance and the Slatkin-Maddison test--to demonstrate that the residual viremia is genetically distinct from proviruses in resting CD4(+) T cells but that proviruses in resting and activated CD4(+) T cells belong to a single population. Residual viremia is genetically distinct from proviruses in activated CD4(+) T cells, monocytes, and unfractionated peripheral blood mononuclear cells. The finding that some of the residual viremia in patients on HAART stems from an unidentified cellular source other than CD4(+) T cells has implications for eradication efforts.
Limited Feedback Precoding for Wireless MIMO Broadcast Channels (2005)

Recently, a number of techniques have been introduced to exploit multiuser diversity of a wireless multiple input multiple output (MIMO) broadcast channel (BC) that consists of a base station (BS) with t transmit antennas and K mobile stations (MS) with multiple antennas. However, prior works have ignored the rate overhead associated with feedback of MIMO BC channel state information (CSI), which is roughly K times larger than single-user MIMO CSI (i.e., it is O(tr) where r = Kk=1 rk and rk is the number of antennas at the kth MS). Considering the amount of feedback signaling, quantization is a necessity for effective feedback transmission as a form of partial CSI. In this paper, we propose the greedy multi-channel selection diversity (greedy MCSD) scheme based on blockMMSE QR decomposition with dirty paper coding (block MMSE-DP), where partial CSI is almost sufficient. The sum-rate performance of our novel scheme approaches extremely close to the sum capacity of MIMO BC as the number of users increases, whereas the feedback overhead is reduced by a factor of 2t3/L(t2−t), in which L is the number of active channel vectors. Simulation results validate the expectation from the analysis.
Regulators of sperm function: Composition of the human zona pellucida and modifications following fertilization (1995)

The composition of individual human zonae pellucidae and modifications to this extracellular coat both before and after fertilization were analysed using a rapid, sensitive, non-radioactive biotinylation- or lectin-based detection system; these assays use commercially available reagents and can be performed on fragments of individual zonae pellucidae. The zona pellucida from unfertilized eggs is composed of three glycoprotein species designated as huZP1, huZP2 and huZP3. Under non-reducing conditions, the molecular weights of these proteins are approximately 150 kDa, approximately 100 kDa, and approximately 55-65 kDa respectively. Following fertilization, huZP1 was not detected under either non-reducing or reducing conditions. In contrast, after fertilization huZP2 was detected under non-reducing conditions, but not under reducing conditions. The ability to detect pre- and post-fertilization changes in a single human zona pellucida is discussed in relation to its value in assessing deficiencies in clinical and laboratory protocols used for in-vitro fertilization.
Structure-activity relationships of C-terminal endothelin hexapeptide antagonists (1993)

The discovery of selective endothelin (ET) receptor antagonists will facilitate identification of the physiological and pathological roles for ET and its isopeptides. Structure-activity studies of the C-terminal hexapeptide of ET have been carried out to elucidate those amino acids important for receptor binding and agonist or antagonist activity. Binding studies were performed in rat heart ventricle, rabbit renal artery vascular smooth muscle cells, and rat cerebellum. In addition, many of the compounds have been evaluated functionally for their effects on endothelin-1-induced arachidonic acid release and inositol phosphate accumulation in specific cell lines. Selected compounds have been evaluated in a functional bioassay in tissue preparations specifically expressing either ETA or ETB receptors. We have previously described the structure-activity relationships in the hydrophobic C-terminal hexapeptide of ET, a region known to be highly important for receptor recognition. A mono-D-amino acid scan of the ET[16-21] revealed that substitution at His gave rise to analogs with significantly enhanced binding affinity. We have further evaluated the C-terminal region and will describe the design, synthesis, and pharmacological evaluation of several novel and potent ET peptide receptor antagonists.
In-situ monitoring of epitaxial film thickness by IEMI (1992)

In-situ measurement of epitaxial film thickness by infrared emission Michelson interferometer (IEMI) is presented. During in-situ experiments, epi wafers were heated inside an ultrahigh vacuum (UHV) single-wafer chemical vapor deposition (CVD) reactor or a furnace and the IR emission from the wafers was analyzed by the MI. In-situ thickness measurements have been made at temperatures ranging from 150 to 900 degrees C for a lightly doped epi layer (0.5 Omega -cm) on top of a heavily doped substrate (0.001-0.002 Omega -cm). The accuracy of in-situ measurements is 2% of the actual epi layer thickness, compared with 0.3% for ex-situ measurements. This technique can be applied to real-time in-situ measurements of epi film growth and to real-time control of epi film thickness.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Tumor-exosomes and leukocyte activation: an ambivalent crosstalk (2012)

ASML-exosomes might well serve as adjuvant in immunotherapy as they support leukocyte effector functions and have only a minor impact on leukocyte activation, which can be overridden by DC. However, exosome-induced modulation of immune cells relies, at least in part, on exosome uptake and message transfer. This implies that depending on the individual tumor's exosome composition, exosomes may distinctly affect the immune system. Nonetheless, whether immunotherapy can profit from using tumor-exosomes as adjuvant can easily be settled beforehand in vitro.
Thermal control and rate of deposition system of chemical vapor deposition at atmospheric pressure ; production of thin tin-oxide films by an APCVD process (2012)

This report covers the design and manufacturing of a new CVD reactor for chemical vapor deposition (CVD) of tin-oxide to glass as well as several related issues such as written process control software, chemical process information and test run results. The CVD process is one step in the production of liquid crystal displays and many other applications. Currently CTI has a working discontinuous atmospheric pressure (APCVD) reactor that needs replacement to allow a process with more degrees of freedom as to conduct a more elaborate research.
The CVD process as carried out at CTI is a process that is chemically not fully understood yet, but results of deposition of tin-oxide are measured. The principles behind the general process as well as the specific process carried out at CTI are treated up to certain detail in this report as well as several important influences on the process.
The design of the new APCVD reactor concerns in fact not the entire reactor, but rather all the involved electrical equipment that is stored in a so called ‘control box’. This control box houses all the mass flow control, electrical and temperature control equipment as well as equipment for the rotational motor of the heater that is necessary for the CVD process. The control box’s design is optimized using 3D CAD software and both an electrical circuit as a gas flow circuit is drawn of the equipment inside.
To control the process digitally via a PC, it was necessary to communicate with the mass flow controllers (MFCs) and hence software has been written to do so. for the equipment came without any control software. The written program, named Deposition Control, is fully explained so anyone acquainted with the used software to write the program can understand and later on adapt the program if necessary.
Finally after finishing the assembly of the equipment and all the connections inside the reactor, several test runs have been carried out to assure proper functioning of the total reactor. During these tests, several improvements have been made to the equipment as well as to the Deposition Control program. This report is concluded with several recommendations for better control of the CVD process in future use.