gebhart/patrepeval huggingface dataset:
Exposure to Factor VIII Protein in the Presence of Phosphatidylserine Induces Hypo-responsiveness toward Factor VIII Challenge in Hemophilia A Mice (2013)

Administration of recombinant factor VIII (FVIII), an important co-factor in blood clotting cascade, elicits unwanted anti-FVIII antibodies in hemophilia A (HA) patients. Previously, FVIII associated with phosphatidylserine (PS) showed significant reduction in the anti-FVIII antibody response in HA mice. The reduction in the immune response to FVIII-PS could be due either to a failure of the immune system to recognize the antigen (i.e. immunological ignorance) or to an active induction of an antigen-specific nonresponsiveness (i.e. immunological tolerance). If it were a result of tolerance, one would predict that pre-exposure to FVIII-PS would render the mice hypo-responsive to a subsequent FVIII challenge. Here, we have demonstrated that naive HA mice that were pretreated with FVIII-PS showed a significantly reduced FVIII immune response to further challenge with native FVIII and that this decreased responsiveness could be adoptively transferred to other mice. An increase in number of FoxP3-expressing CD4(+) regulatory T-cells (Treg) was observed for the FVIII-PS-immunized group as compared with animals that received FVIII alone, suggesting the involvement of Treg in PS-mediated hypo-responsiveness. The PS-mediated reduction in antibody response was reversed by the co-administration of function-blocking anti-TGF-β antibody with FVIII-PS. The decreased response to FVIII induced by FVIII-PS was determined to be antigen-specific because the immune response to another non-cross-reactive antigen (ovalbumin) was not altered. These results are consistent with the notion that FVIII-PS is tolerogenic and suggest that immunization with this tolerogenic form of the protein could be a useful treatment option to minimize immunogenicity of FVIII and other protein-based therapeutics.
Multifaceted Reactions of P(CH<sub>2</sub>OH)<sub>3</sub> with Rhenium(V) Precursors. Synthesis, Characterization, and X-ray Structural Studies of <i>trans,trans,trans</i>-[ReO<sub>2</sub>{P(CH<sub>2</sub>OH)<sub>3</sub>}<sub>2</sub>- (py)<sub>2</sub>]Cl, <i>trans,cis,cis</i>-[ReO<sub>2</sub>{P(CH<sub>2</sub>OH)<sub>3</sub>}<sub>2</sub>(py)<sub>2</sub>]Cl, and Novel Alkoxide [Re(O)(μ-O)- (P{CH<sub>2</sub>OH}<sub>3</sub>)(μ-η<sup>2</sup>-P{CH<sub>2</sub>OH}<sub>2</sub>CH<sub>2</sub>O)]<sub>4</sub> (1998)

The reaction of the water-soluble monophosphine tris(hydroxymethyl)phosphine (THP, 1) with [ReO2(py)4]Cl produced either trans,trans,trans-[ReO2(THP)2(py)2]Cl (3, referred to as trans-[ReO2(THP)2(py)2]Cl throughout the text) or trans,cis,cis-[ReO2(THP)2(py)2]Cl (4, referred to as cis-[ReO2(THP)2(py)2]Cl throughout the text) depending on the reaction conditions. In contrast, the reaction of THP with ReO2I(PPh3)2 in biphasic media produced the novel, neutral, cyclic tetranuclear, rhenium(V) alkoxide 5 in low yields. A similar reaction of bis(hydroxymethyl)phenylphosphine (2) with [ReO2(py)4]Cl produced the trans,trans,trans-[ReO2{PPh(CH2OH)2}2(py)2]Cl complex (6, referred to as trans-[ReO2{PPh(CH2OH)2}2(py)2]Cl throughout the text) in high yields. All compounds were characterized by 31P, 1H, and 13C NMR spectroscopy and mass spectroscopy. X-ray data for 3: monoclinic, C2/c, a = 17.7964(11) Å, b = 8.8972(6) Å, c = 15.3247(9) Å, β = 97.683(1)°, Z = 4, R = 0.0179 (Rw = 0.0426). X-ray data for 4: monoclinic, P21/n, a = 12.1025(7) Å, b = 12.2670(7) Å, c = 15.5230(9) Å, β = 97.683(1)°, Z = 4, R = 0.0191 (Rw = 0.0483). X-ray data for 5: monoclinic, P2/c, a = 12.3759(7) Å, b = 9.8274(5) Å, c = 22.4272(12) Å, β = 96.807(1)°, Z = 2, R = 0.0437 (Rw = 0.0887). X-ray data for 6: monoclinic, P21/n, a = 9.3654(5) Å, b = 13.2578(7) Å, c = 12.0257(7) Å, b = 107.0480(10)°, Z = 2, R = 0.0218 (Rw = 0.0578).
The α-amylase of the caldoactive bacterium <i>Bacillus caldovelox</i> (1990)

Conference Article| April 01 1990 The α-amylase of the caldoactive bacterium Bacillus caldovelox FRANCIS J. BEALIN-KELLY; FRANCIS J. BEALIN-KELLY 1Department of Industrial Microbiology, University College Dublin, Belfield, Dublin 4, Republic of Ireland Search for other works by this author on: This Site PubMed Google Scholar CATHERINE T. KELLY; CATHERINE T. KELLY 1Department of Industrial Microbiology, University College Dublin, Belfield, Dublin 4, Republic of Ireland Search for other works by this author on: This Site PubMed Google Scholar WILLIAM M. FOGARTY WILLIAM M. FOGARTY 1Department of Industrial Microbiology, University College Dublin, Belfield, Dublin 4, Republic of Ireland Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1990) 18 (2): 310–311. https://doi.org/10.1042/bst0180310 Article history Received: September 06 1989 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation FRANCIS J. BEALIN-KELLY, CATHERINE T. KELLY, WILLIAM M. FOGARTY; The α-amylase of the caldoactive bacterium Bacillus caldovelox. Biochem Soc Trans 1 April 1990; 18 (2): 310–311. doi: https://doi.org/10.1042/bst0180310 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: G1, glucose, G2, maltose, G3, maltotriose, G4, maltotetraose, G5, maltopentaose, G6, maltohexaose This content is only available as a PDF. © 1990 Biochemical Society1990 Article PDF first page preview Close Modal You do not currently have access to this content.
Construction of New Delay-Tolerant Space-Time Codes (2011)

Perfect space-time codes (STC) are optimal codes in their original construction for multiple-input multiple-output (MIMO) systems. Based on cyclic division algebras (CDA), they are full-rate, full-diversity codes, have non-vanishing determinants (NVD) and hence achieve diversity-multiplexing tradeoff (DMT). In addition, these codes have led to optimal distributed space-time codes when applied in cooperative networks under the assumption of perfect synchronization between relays. However, they lose their diversity when delays are introduced and thus are not delay-tolerant. In this paper, using the cyclic division algebras of perfect codes, we construct new codes that maintain the same properties as perfect codes in the synchronous case. Moreover, these codes preserve their full-diversity in asynchronous transmission.
Substituted Bisphenols as Antioxidants for Autoxidation of Tetralin (1989)

Abstract The antioxidative activities of nineteen compounds of seven series of alkylidene- and benzylidenebisphenols were evaluated by means of an oxygen-absorption method at 60 °C for tetralin. The electrochemical oxidation potentials determined using linear-sweep voltammetry and the 13C NMR chemical shifts (δ) of these compounds were obtained. These data were associated with the antioxidative activities. In particular, the activities exhibited by the induction period (min) were found to closely correlate with the 13C chemical shifts of the ipso-carbon of the OH substituent (corr. coeff.=0.991). Very good activities have been observed with a series of 2,2′-alkylidene- and benzylidenebis(4,6-dimethylphenol) derivatives.
Acute and Long-Term Effects of Subthalamic Nucleus Stimulation in Parkinson's Disease (1994)

In animal models of Parkinson's disease (PD), it is postulated that the excessive output from the subthalamic nucleus (STN) plays a critical role. Selective lesions or high frequency electrical stimulation of the STN can alleviate parkinsonian symptoms in MPTP-treated monkeys. We decided to carry out STN stimulation in patients suffering from severe akinetic forms of PD. After approval of the institutional ethical committee, we operated on a parkinsonian patient aged 51, suffering for 8 years from a strongly disabling akinetorigid form of PD, complicated by an on-off effect (Hoehn and Yahr stage 5 in the worst-off motor phase). Stereotactic surgery was done on one side under local anesthesia. The theoretical target was chosen according to stereotactic atlases, based on ventriculographic landmarks such as anterior and posterior commissures (AC and PC). The final position of the chronic electrodes was optimized using electrophysiological recording and stimulation along with clinical assessment and surface EMG of agonist and antagonist muscles of the examined limbs. A spontaneous increase in neuronal activity was recorded in an area located 2-4 mm under the level of the intercommissural plane, 10 mm from the midline, at mid-distance between AC and PC. Within the same place, a 130-Hz stimulation induced acute and reversible akinesia alleviation mainly on the contralateral limbs, comparable to that obtained with dopaminergic drugs. No dyskinesia, such as hemiballism, was induced by introduction of electrodes or by stimulation. Then a long-term quadripolar DBS Medtronic electrode was inserted in this area. Studies of the effects of chronic stimulation were extensively performed to determine the best spatiotemporal and electrical stimulation variables.(ABSTRACT TRUNCATED AT 250 WORDS)
Data Sharing and Self-Destruction Scheme in Cloud (2017)

There is a huge use of cloud services in our day today life e.g. Google Drive, Dropbox, SharePoint etc. Sharing data within friends might consist of sensitive/personal information. It's always the users responsibility to safeguard own data while sharing and avoid misuse of it. It becomes a challenge for user to protect self-data on cloud network, to overcome this scenario it is important to design and allocate self-destruct period assigned by the user and access control to the data until the expiry period. The shared data should be self-destructed after the user-defined expiration time. With the help of KPABE (Key-policy ABE) and where can apply time interval to each attribute in the form of decryption attributes. In the KP-TSABE scheme, every cipher text is labeled with a time interval while private key is associated with a time instant. Deletion of data in a secure way is the task of deleting data irrecoverably from a physical storage medium. In this digital world, data is not securely deleted by default; instead, many approaches add secure deletion to existing physical medium interfaces.
Self-checking widgets for interactive cockpits (2011)

In the last few years, glass cockpits are being replaced by interactive cockpits to provide a much higher level of integration. Due to their event driven nature, interactive systems offer more display and control features but also more unpredictable side effects. Exhaustive testing being impossible, fault tolerant techniques have to be considered. This paper proposes a model-based approach for adding fault-tolerance mechanisms to interactive cockpits. The contribution is focused on the implementation of self-checking widgets, being the basis for interactive cockpits.
Model based, sensor directed remediation of underground storage tanks (2002)

Experimental investigations into the application of intelligent robot control technology to the problem of removing waste stored in tanks are described, with particular attention paid to the computing and software environment. Intelligent system control is achieved through the integration of extensive geometric and kinematic world models with real-time sensor-based control. All operator interactions with the system are through fully animated, graphical representations, which validate all operator commands before execution to provide for safe operation. Sensing is used to add information to the robot system's world model and to allow sensor-based servocontrol during selected operations. The results of a first critical features test are reported, and the potential for applying advanced intelligent control concepts to the removal of waste in storage tanks is discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Post-steam-treatment of Mo/HZSM-5 Catalysts:  An Alternative and Effective Approach for Enhancing Their Catalytic Performances of Methane Dehydroaromatization (2003)

Post-steam-treatment is a facile and effective method for improving the catalytic performances of Mo/HZSM-5 catalysts in methane dehydroaromatization under nonoxidative conditions. The treatment can enhance the stability of the catalyst and also give a higher methane conversion and a higher yield of light aromatics, as well as a decrease in the formation rate of carbonaceous deposits. 27Al, 29Si, and 1H multinuclear magic angle spinning nuclear magnetic resonance, X-ray photoelectron spectroscopy, X-ray diffraction, X-ray fluorescence spectroscopy, and thermogravimetric analysis measurements as well as catalytic reaction evaluations were employed to conduct comparative studies on the properties of the catalysts before and after the post-steam-treatment. The results revealed that the number of free Brönsted acid sites per unit cell decreased, while more Mo species migrated into the HZSM-5 channels for the 6Mo/HZSM-5 catalysts after the post-steam-treatment. In addition, the average pore diameter was also larger for the post-steam-treated catalysts, and this was advantageous for mass transport of the reaction products. However, a severe post-steam-treatment, i.e., with longer treating time, of the 6Mo/HZSM-5 catalyst will lead to the formation of the Al2(MoO4)3 phases, which is detrimental to the reaction.
Transient Bragg reflection gratings in erbium-doped fiber amplifiers (1992)

A transient tunable Bragg reflection grating has been established in an erbium-doped fiber amplifier by the effect of a standing wave produced by counterpropagating cw light. Less than 1 mW of cw light was required to establish a grating with a 75% reflection coefficient at 1536 nm and an optical bandwidth (FWHM) of 16 MHz.Possible applications include dispersion compensation and dense wavelength-division multiplexing.
Design, Fabrication and Testing of Miniaturised Wireless Inertial Measurement Units (IMU) (2007)

This paper will describe the design, fabrication, operation, and test results of a miniature wireless inertial measurement unit (WIMU) with a form factor of 10 mm. Many types of Inertial Measurement Units(IMU) have been designed and manufactured by prominent companies such as Crossbow, Xsens, O NAVI and Honeywell, among many others. American GNC Corporation currently claims to have the world's smallest IMU[1]. Most of these IMUs are aimed at aerospace and other types of navigation, which is why miniaturisation has not been a priority. However, with the onset and development of MEMS technology, novel applications have been found for those MEMS sensors employed in an IMU. Head mounted displays, Segways and mobile phones are among the new products taking advantage of miniaturised MEMS inertial sensors. The current WIMU development is a step along the roadmap of the AES team at Tyndall National Institute towards miniaturisation and works from the current standard, the 25 mm platform [2]. A 25 mm stacked SMT IMU has been successfully developed and tested [3,4]. The goal now is to develop an even smaller version of this IMU by using advanced technology such as flexible substrates and flip-chip technique. These miniaturised IMU's are required for wearable and medical applications where size and weight are priorities. Our WIMU uses bare-die versions of off-the-shelf MEMS sensors. The Inertial Measurement Unit itself is designed to give full six degrees of freedom with 3-axis for each of the sensors-accelerometers, gyroscopes and magnetometers.
Cloning and sequence analysis of the major outer membrane protein genes of two Chlamydia psittaci strains (1989)

We cloned and sequenced the gene encoding the major outer membrane protein (MOMP) of two Chlamydia psittaci strains, guinea pig inclusion conjunctivitis (GPIC) strain 1, and meningopneumonitis (Mn) strain Cal-10. Intraspecies alignment of the two C. psittaci MOMP genes revealed 80.6% similarity, and interspecies comparison of C. trachomatis and C. psittaci MOMP genes yielded about 68% similarity. As found previously for C. trachomatis MOMP sequences, stretches of predominantly conserved sequences of GPIC and Mn MOMPs were interrupted by four variable domains whose locations were identical to those of C. trachomatis MOMPs. Seven of eight cysteine residues were found at precisely the same positions in GPIC, Mn, and C. trachomatis MOMPs, emphasizing their importance in structure and function of the protein. Collectively, these results indicate that C. psittaci and C. trachomatis MOMP genes diverged from a common ancestor.
Pain control by CXCR2 ligands through Ca <sup>2+</sup> ‐regulated release of opioid peptides from polymorphonuclear cells (2006)

Leukocytes counteract inflammatory pain by releasing opioid peptides, which bind to opioid receptors on peripheral sensory neurons. In the early phase of inflammation, polymorphonuclear cells (PMN) are the major source of opioids. Their recruitment is governed by ligands at the chemokine receptor CXCR2. Here, we examined whether chemokines can also induce opioid peptide secretion from PMN and thus inhibit inflammatory pain. In rats with hindpaw inflammation, intraplantar injection of CXCL2/3, but not of the CXCR4 ligand CXCL12, elicited naloxone-reversible (i.e., opioid receptor mediated) mechanical and thermal analgesia, which was abolished by systemic PMN depletion. Both CXCR1/2- and CXCR4-ligands induced PMN chemotaxis, but only CXCR1/2 ligands triggered opioid release from human and rat PMN in vitro. This release was unaltered by extracellular Ca2+ chelation, was mimicked by thapsigargin and was blocked by inhibitors of the inositol 1,4,5-triphosphate receptor (IP3) and by intracellular Ca2+ chelation, indicating that it required Ca2+ from intracellular but not extracellular sources. Furthermore, release was partially reduced by phosphoinositol-3-kinase (PI3K) inhibitors. Adoptive transfer of allogenic PMN into PMN-depleted rats reconstituted CXCL2/3-induced analgesia, which was inhibited by prior ex vivo chelation of intracellular Ca2+. These findings demonstrate that, beyond cell recruitment, CXCR2 ligands induce Ca2+-regulated opioid release from PMN and thereby inhibit inflammatory pain in vivo.
Multi-focus image fusion using epifluorescence microscopy for robust vascular segmentation (2014)

Automatic segmentation of three-dimensional mi-crovascular structures is needed for quantifying morphological changes to blood vessels during development, disease and treatment processes. Single focus two-dimensional epifluorescent imagery lead to unsatisfactory segmentations due to multiple out of focus vessel regions that have blurred edge structures and lack of detail. Additional segmentation challenges include varying contrast levels due to diffusivity of the lectin stain, leakage out of vessels and fine morphological vessel structure. We propose an approach for vessel segmentation that combines multi-focus image fusion with robust adaptive filtering. The robust adaptive filtering scheme handles noise without destroying small structures, while multi-focus image fusion considerably improves segmentation quality by deblurring out-of-focus regions through incorporating 3D structure information from multiple focus steps. Experiments using epifluorescence images of mice dura mater show an average of 30.4% improvement compared to single focus microvasculature segmentation.
Capacitor ChargingfromBatteries with (1969)

The majorproblems encountered indesigning conver- tersforcapacitor charging arediscussed. A design approach isout- lined fordesigning aninductive storage (blocking oscillator) type converter andadesign example given. Particular emphasis isplaced onproblems associated withusing low-voltage nickel cadmiumcells topowertheconverter.
Geometry-Induced Asymmetric Capillary Flow (2014)

When capillary flow occurs in a uniform porous medium, the depth of penetration is known to increase as the square root of time. However, we demonstrate in this study that the depth of penetration in multi-section porous layers with variation in width and height against the flow time is modified from this diffusive-like response, and liquids can pass through porous systems more readily in one direction than the other. We show here in a model and an experiment that the flow time for a negative gradient of cross-sectional widths is smaller than that for a positive gradient at the given total height of porous layers. The effect of width and height of local layers on capillary flow is quantitatively analyzed, and optimal parameters are obtained to facilitate the fastest flow.
THE APPLICATION OF ADVANCED TECHNIQUES FOR MODIFICATION COMPLEX FOCUSED-ION-BEAM DEVICE (1996)

Advanced techniques for focused-ion-beam (FIB) device modification have been developed for complex, multistep modifications to circuitry on planar chip technology. Applying gas-assisted etching (GAE) techniques for high-aspect-ratio milling and the selective milling of both conductive and insulating films enhances process latitude. Localized ion-beam-induced deposition of an insulating film provides reconstructive capability in previously modified areas. The application of both techniques for complex device modification of VLSI devices fabricated with CMOS process technology is reviewed. Copyright 0 1996 Elsevier Science Ltd
LDP Lean Document Production—O.R.-Enhanced Productivity Improvements for the Printing Industry (2009)

Xerox has invented, tested, and implemented a novel class of operations-research-based productivity-improvement offerings, trademarked LDP Lean Document Production® solutions, for the $100 billion printing industry in the United States. These solutions, which Xerox has implemented in approximately 100 sites to date, have provided dramatic productivity and cost improvements for both print shops and document-manufacturing facilities, as measured by reductions of 20–40 percent in revenue-per-unit labor cost. They have generated approximately $200 million of incremental profit across the Xerox customer value chain since their initial introduction in 2000. The offerings have extended the use of operations research to small- and medium-sized print shops, while increasing the scope of its application to large document-production facilities.
Characterization of a top quality embryo, a step towards single-embryo transfer (1999)

In most in-vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) programmes approximately one ongoing pregnancy in three is multiple. The need to characterize embryos with optimal implantation potential is obvious. We retrospectively examined all of 23 double transfers resulting in ongoing twins, occurring between January 1, 1996 and May 19, 1997. Characteristics of these top quality embryos were absence of multinucleated blastomeres, four or five blastomeres on day 2, seven or more cells on day 3, and </=20% anucleated fragments. In a subsequent series of 400 IVF/ICSI cycles (out of which 372 were selected for embryo transfer) from May 20, 1997 to July 31, 1998, only women <38 years of age had multiple pregnancies: after 221 transfers of two embryos, 45/116 (39%) were multiple, and after 77 transfers of >2 embryos, 11/31 (35%) were multiple. We applied our top quality criteria to the 221 double transfers: 106 transfers with two top embryos resulted in 65 (63%) ongoing pregnancies with 37 (57%) twins, 65 transfers with one top embryo in 38 (58%) ongoing pregnancies with eight (21%) twins. In the group without top embryos, 12/52 (23%) ongoing singletons occurred, with no twins. The corresponding ongoing implantation rates were 49, 35 and 12%. This analysis suggests that single embryo transfer with an acceptable pregnancy rate might be considered if a top quality embryo is available.