gebhart/patrepeval huggingface dataset:
VEGF and TNF up-regulate, NSAID down-regulate SOX18 protein level in HUVEC (2010)

Abstract Angiogenesis, the process of generating new blood vessels, is essential to embryonic development, organ formation, tissue regeneration and remodeling, reproduction and wound healing. Also, it plays an important role in many pathological conditions, including chronic inflammation and cancer. Angiogenesis is regulated by a complex interplay of growth factors, inflammatory mediators, adhesion molecules, morphogens and guidance molecules. Transcription factor SOX18 is transiently expressed in nascent endothelial cells during embryonic development and postnatal angiogenesis, but little is known about signaling pathways controlling its expression. The aim of this study was to investigate whether pro-angiogenic molecules and pharmacological inhibitors of angiogenesis modulate SOX18 expression in endothelial cells. Therefore, we treated human umbilical vein endothelial cells (HUVEC) with angiogenic factors, extracellular matrix proteins, inflammatory cytokines and nonsteroidal anti-inflammatory drugs (NSAID) and monitored SOX18 expression. We have observed that the angiogenic factor VEGF and the inflammatory cytokine TNF increase, while the NSAID ibuprofen and NS398 decrease the SOX18 protein level. These results for the first time demonstrate that SOX18 expression is modulated by factors and drugs known to positively or negatively regulate angiogenesis. This opens the possibility of pharmacological manipulation of SOX18 gene expression in endothelial cells to stimulate or inhibit angiogenesis.
Waveform shaped MCM for digital microwave radio (2002)

The waveform shaped multicarrier modulation (MCM) is considered for high capacity data transmission in digital microwave radios. The degradations of the MCM system performance caused by the multipath fading of the line-of-sight (LOS) radio channel are investigated. A 512-carrier system with a data rate of 155 Mb/s is described and simulated. The signal-to-interference ratio and the signature curve of the MCM system are evaluated by using Rummler's (1979) channel model. Simulations show the robustness of the system in the multipath fading channel. The simulated results for adaptive channel estimation are also given.
Maturing iPSC-Derived Cardiomyocytes (2020)

Cardiovascular disease is a major cause of mortality worldwide. The advent of human-induced pluripotent stem cells (hiPSCs) technology have enabled the reliable generation of individual-derived cardiomyocytes (CMs) [1] [...].
Adoptively transferred CD4+ lymphocytes from CD8 -/- mice are sufficient to mediate the rejection of MHC class II or class I disparate skin grafts (1996)

Recent studies revealed that CD4+ cells initiate allograft rejection through direct recognition of allogeneic MHC class II Ags and indirect recognition of MHC peptides processed by self APCs. Both pathways were shown to help CD8+ cells that eventually lysed allogeneic MHC class I-presenting targets. There was little evidence, however, that CD4+ cells are sufficient for graft rejection. We studied skin graft rejection by CD8-deficient (CD8 -/-) mice. We showed that BALB/cJ(H-2d) CD8 -/- mice could reject allogeneic skin from C57BL/6J(H-2b) mice deficient in MHC class I or in MHC class II Ags. To understand the role of CD4+ cells in this process, we isolated them from CD8 -/- mice and transferred them to BALB/cJ nude mice that had been grafted with allogeneic skin (H-2b) from animals deficient in MHC class I or MHC class II. Nude mice injected with CD4+ cells rejected MHC class II and, albeit more slowly, MHC class I disparate skins. We showed in vitro evidence that CD4+ cells were not cytotoxic toward MHC class I or MHC class II disparate targets and that they recognized MHC class I allogeneic targets through indirect recognition. CD4+ cells produced Th1 cytokines, but not IL-4, following stimulation with allogeneic cells. Furthermore, intragraft TNF-alpha was elevated in skin grafted onto nude mice reconstituted with CD4+ cells compared with nonreconstituted mice. This suggests that MHC class II- or MHC class I-guided CD4+ cells alone are sufficient to induce rejection by the generation of cytokine-induced lesions.
An identity-based authentication protocol for sensor networks (2014)

We proposed an identity-based symmetric key authentication protocol using the Multiple-Key Blom's key agreement scheme as the underlying cryptographic system. This scheme enables a pair of nodes to compute a secret pairwise key using each other's identity. The protocol has two modes of operations. In mode 1, the long term pairwise key is used for encryption while in mode 2, the nodes use a randomly generated session key. Communications start in mode 1 and the receiving node is able to authenticate the sender after receiving a single initial message. The protocol subsequently switches to mode 2 if a response is received, if not, communications fall back to using mode 1. The exposure to attacks is minimal and all messages are encrypted using the pairwise keys.
The Value of Information in Retrospect (2018)

In the course of any statistical analysis, it is necessary to consider issues of data quality and model appropriateness. Value of information methods were initially put forward in the middle of the twentieth century in order to provide a framework for choosing between potential sources of information. However, since their genesis, value of information methods have been largely neglected by statisticians. In this paper we review and extend existing value of information methods and recommend the use of three quantities for identifying influential and outlying data: an influence measure previously suggested by \cite{kempthorne1986}, a related quantity known as the expected value of sample information that is used to gauge how much influence we would expect a portion of the data to have, and the ratio of these two quantities which serves as a comparison between observed influence and expected influence. We study the basic theoretical properties of those quantities and illustrate our proposed approach using two datasets. A data set containing employment rates and other economic factors in U.S. first presented by \cite{longley} is used to provide an example in the case of linear regression. HIV surveillance data collected from prenatal clinics have been the main source of information for monitoring the HIV epidemic in low and middle income countries. A data set providing information about HIV prevalence in Swaziland is used as an example in the case of generalized linear mixed models.
Full characterization of quantum optical detectors (2009)

Full characterization of detectors in the quantum regime is presented. We determine the POVM elements of a photon-number-resolving detector. A method for precise calibration of detector efficiency is demonstrated.
Effect of DC Field and X-Ray Irradiation on Dielectric Properties of ZnF2–PbO–TeO2 Glasses (1995)

Dielectric constant ϵ, loss tan δ, and conductivity σ of ZnF2-PbO-TeO2 glasses (composition 20, 12, 68 by wt%), subjected to X-ray irradiation for 1 h in the presence of a dc field up to 15 kV cm−1, are measured in the frequency range 2 × 102 to 107 Hz and in the temperature range 30 to 200 °C. The space charge and dipolar effects observed from this study are discussed in the light of point defects created in these glasses.
High dynamic range real-time 3D shape measurement (2016)

This paper proposes a method that can measure high-contrast surfaces in real-time without changing camera exposures. We propose to use 180-degree phase-shifted (or inverted) fringe patterns to complement regular fringe patterns. If not all of the regular patterns are saturated, inverted fringe patterns are used in lieu of original saturated patterns for phase retrieval, and if all of the regular fringe patterns are saturated, both the original and inverted fringe patterns are all used for phase computation to reduce phase error. Experimental results demonstrate that three-dimensional (3D) shape measurement can be achieved in real time by adopting the proposed high dynamic range method.
Contribution of HLA Class I Allele Expression to CD8<sup>+</sup> T‐Cell Responses against Epstein–Barr Virus (2002)

Most immune responses to viral infections involve CD8+ T cells recognizing viral peptides of typically 9-10 amino acids in the groove of major histocompatibility complex (MHC) class I. Importantly, CD8+ T-cell responses appear to focus on few viral epitopes, a phenomenon termed immunodominance. While the understanding of this phenomenon has been based largely on experimental mice models, it is imperative to evaluate its contribution in humans, as the design of peptide-based vaccines may be influenced by immunodomination. Here, we present evidence that immunodominance can be detected among Epstein-Barr virus (EBV) epitopes associated with two of the most frequent class I alleles in Western Europe, human leucocyte antigen (HLA)-A2 and HLA-B7. CD8+ T-cell responses to HLA-A2-associated EBV epitopes were significantly reduced in individuals coexpressing HLA-B7. The impairment of HLA-A2-associated responses correlated with a dominant response to an HLA-B7 epitope. The data demonstrate a hierarchy in the human cellular immune response to immunodominant EBV epitopes presented by separate HLA class I alleles. This may have implications for EBV vaccine development as well as for the interpretation of isolated analysis of immunodominant responses to EBV.
Time-resolved optical microscopy of a laser-based forward transfer process (2001)

Matrix-assisted pulsed laser evaporation direct write was investigated by ultrahigh speed optical microscopy. A composite barium–zirconium titanate/α-terpineol layer was irradiated by 355 nm laser pulses with a 150 ns pulse width, and it was observed that material removal does not begin until after the end of the pulse (t&gt;200 ns) and continues for 1 μs after the irradiation. The desorption plume consists of micron-size particles moving with a velocity of ∼0.2 km/s. The slow response is attributed to the combination of particle absorbers and highly viscous fluid. The ability to form continuous, pinhole-free coatings is due to slow coalescence of the particles.
Fringe-shift generators for characterizing interferometer system response (1973)

Two techniques have been developed for the generation of well characterized fringe patterns in displacement and velocity interferometers. In the first, a piezoelectric crystal placed at the interferometer target location is oscillated at resonance with applied ac voltages near 100 V. Quartz or lithium niobate crystals with resonant frequencies near 1 MHz produce surface displacements of 200–1000 nm, and peak surface velocities of 0.4–4.0 m/sec. The fringe-shift patterns produced in the interferometer using this technique can be used to test various aspects of the interferometer performance. The second technique employs a fused silica disk which is rotated in one leg of the interferometer. This rotation introduces a large variation ([inverted lazy s] 0.3 mm) in the optical path length of the interferometer leg during each revolution, giving a fringe shift of hundreds of fringes. This technique is especially useful for maximizing interferometer fringe contrast during setup of the instrument.
Novell IPX Over Various WAN Media (IPXWAN) (1993)

This document describes how Novell IPX operates over various WAN media.Specifically, it describes the common "IPX WAN" protocol Novell uses to exchange necessary router to router information prior to exchanging standard IPX routing information and traffic over WAN datalinks.This document supercedes RFC 1362 and adds capability for Unnumbered RIP links, On-demand statically routed links and client to router connectivity.
Highly Enantioselective Alkynylation of Aldehydes Promoted by Chiral Oxazaborolidines (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHighly Enantioselective Alkynylation of Aldehydes Promoted by Chiral OxazaborolidinesE. J. Corey and Karlene A. CimprichCite this: J. Am. Chem. Soc. 1994, 116, 7, 3151–3152Publication Date (Print):April 1, 1994Publication History Published online1 May 2002Published inissue 1 April 1994https://pubs.acs.org/doi/10.1021/ja00086a066https://doi.org/10.1021/ja00086a066research-articleACS PublicationsRequest reuse permissionsArticle Views1658Altmetric-Citations139LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Quantitative Studies on the Influence of the Bean Roasting Parameters and Hot Water Percolation on the Concentrations of Bitter Compounds in Coffee Brew (2010)

To investigate the influence of roasting time and temperature on the degradation of the bitter precursors 3-O-caffeoyl quinic acid (1), 5-O-caffeoyl quinic acid (2), and 4-O-caffeoyl quinic acid (3) as well as the formation of bitter tastants during coffee roasting, we prepared coffee brews from beans roasted either at 260 degrees C for 60-600 s or for 240 s at 190-280 degrees C. By means of HPLC-UV/vis and HPLC-MS/MS, bitter-tasting monocaffeoyl quinides (4-8), dicaffeoyl quinides (9-11), and 4-vinylcatechol oligomers (12-20) as well as the parent bitter precursors 1-3 were quantitatively analyzed in these brews. Quinides 4-11, exhibiting a coffee-typical bitter taste profile, were found to be preferentially formed under slight to medium roasting degrees and were observed to be degraded again to generate harsh bitter-tasting 4-vinylcatechol oligomers under more severe roasting conditions, thus matching the change in bitter taste quality observed by means of sensory studies. In addition, quantitative studies of the release profile of bitter compounds from ground coffee upon water percolation revealed that compounds 1-8 were rapidly extracted, dicaffeoyl quinides 9-11 were released rather slowly, and, in particular, compounds 12-17 were found to show strong retention to the ground coffee material. These data imply that the knowledge-based control of the roasting and/or the extraction conditions might be helpful in tailoring the bitter taste signature of coffee beverages.
Dietary L-carnitine Stimulates Carnitine Acyltransferases in the Liver of Aged Rats (2002)

Aging affects oxidative metabolism in liver and other tissues. Carnitine acyltransferases are key enzymes of this process in mitochondria. As previously shown, the rate of transcription and activity of carnitine palmitoyltransferase CPT1 are also related to carnitine levels. In this study we compared the effect of dietary l-carnitine (100 mg l-carnitine/kg body weight/day over 3 months) on liver enzymes of aged rats (months 21-24) to adult animals (months 6-9) and age-related controls for both groups. The transcription rate of CPT1, CPT2, and carnitine acetyltransferase (CRAT) was determined by quantitative reverse transcription real-time PCR (RTQPCR) and compared to the activity of the CPT1A enzyme. The results showed that the transcription rates of CPT1, CPT2, and CRAT were similar in aged and adult control animals. Carnitine-fed old rats had a significant (p<0.05) 8-12-fold higher mean transcription rate of CPT1 and CRAT compared to aged controls, adult carnitine-fed animals, and adult controls, whereas the transcription rate of CPT2 was stimulated 2-3-fold in carnitine-fed animals of both age groups. With regard to the enzymatic activity of CPT1 there was a 1.5-fold increase in the old carnitine group compared to all other groups. RNA in situ hybridization also indicated an enhanced expression of CPT1A in hepatocytes from l-carnitine-supplemented animals. These results suggest that l-carnitine stimulates transcription of CPT1, CPT2, and CRAT as well as the enzyme activity of CPT1 in the livers of aged rats.
Vaccination of Chickens against Newcastle Disease with Live and Inactivated Newcastle Disease Virus (1980)

Chickens were vaccinated and revaccinated with inactivated Newcastle disease (ND) vaccines from 2 different sources and also with LaSota strain, live Newcastle disease virus (NDV). Both inactivated vaccines induced higher virus neutralizing (VN) and hemagglutination-inhibition (HI) titers than the LaSota virus. One of the inactivated preparations was found superior to the other by both the VN and HI tests. However, poor protection from apparent virus replication, virus shed, and transmission occurred after challenge with a velogenic NDV strain in those vaccinated with each of the inactivated vaccines. In contrast, LaSota virus, given by the eye drop route, produced excellent protection by the same criteria. In one of the groups of chickens, gross lesions of airsacculitis were seen after vaccination with an inactivated vaccine and subsequent challenge. Revaccination with inactivated vaccines did not enhance the protection of the respiratory tract but did result in an anamnestic serological response (VN and HI). In the post-challenge period, the use of tracheal swabs proved more sensitive as an indicator of virus shed than did cloacal swabs with the velogenic NDV strain used. The practical implications of observations made from the trials are discussed.
The NEES geotechnical centrifuge at UC Davis (2004)

The Center for Geotechnical Modeling at UC Davis operates a 9.1-m radius geotechnical centrifuge equipped with a 2 m x 1 m servo-hydraulic shaking table. This equipment has been used in geotechnical earthquake engineering research since 1994. In October 2000, UC Davis was selected as a host equipment site on the National Science Foundation's George E. Brown, Jr., Network for Earthquake Engineering Simulation. This four-year upgrade project represents a $5M investment in the UC Davis centrifuge facilities by NSF with an additional $1M from UC Davis. NEES at UC Davis capitalized on the size of the centrifuge and innovations in instrumentation and information technology to enable generation of higher resolution information (control, sensors, and images) and to create more realistic physical models. With NEES the Center for Geotechnical Modeling is working to implement advanced instrumentation, digital video, robotics, and geophysical testing to increase the quality and quantity of data that can be collected; to increase the capacity of the centrifuge; and to develop a biaxial shaking capability. These improvements will allow us to extract more detailed and more accurate information from experiments and simulations, maximizing the information and knowledge that can be gained from these experiments. The Center for Geotechnical Modeling facilities are intended for use by researchers from academia and industry, from both the US and abroad. The centrifuge at UC Davis will be a shared-use facility under NEES, with experiments being performed by teams of researchers. New hardware and software developments are currently being implemented as part of the NEESgrid System Integration project. These new resources will allow teams to collaborate regardless of their physical location. Remote researchers will be able to control their experiments at UC Davis as easily as local researchers. Further information about the UC Davis NEES site can be obtained at http://nees.ucdavis.edu, or by email to cgm@ucdavis.edu.
Precision transmission electron microscopy sample preparation using a focused ion beam by extraction method (1997)

A new precision cross-sectional transmission electron microscopy (XTEM) sample preparation method was developed and is reported here. The major advantage of this method over a conventional sample prepared using a focused ion beam (FIB) microsection is that the sample sectioned with a FIB can be extracted directly from the matrix and transferred to a carbon supporting grid for TEM examination. With this technique, a XTEM sample can be prepared, totally eliminating the requirement for mechanical polishing. Samples can be made easily and quickly, thus enhancing both productivity and turnaround time.
Occluded Street Objects Perception Algorithm of Intelligent Vehicles Based on 3D Projection Model (2018)

We present a super perception system of intelligent vehicles for perceiving occluded street objects by collecting images from neighbor front vehicles V2V (vehicle to vehicle) video streams based on 3D projection model. This super power can avoid some serious accidents of driver-assistant systems or automatic driving systems which can only detect visible objects. Our street perception system can “see through” the front vehicles to realize detecting of the occluded street objects only by analyzing the pair images received from front and host (back) vehicles. Upon the 3D projection model based on the pair images, the system uses affine transformation to achieve augmented reality method to increase the visibility perspective of driver system. Experimental results on different datasets are shown to validate our approach. Evaluation method was first introduced into our perception system.
Induction of estrogen‐related hyperplastic changes in the prostate of the cynomolgus monkey (<i>Macaca fascicularis</i>) by androstenedione and its antagonization by the aromatase inhibitor 1‐methyl‐androsta‐1,4‐diene‐3,17‐dione (1987)

The cynomolgus monkey was selected as an experimental model to investigate the role of estrogens in the pathogenesis of benign prostatic hyperplasia (BPH) because its prostate seems to be more like the human prostate than that of other primate species. The treatment of intact, adult animals with the aromatizable substrate androstenedione for 3 months resulted in no significant changes in prostate weight, but in microscopically clearly detectable estrogen-related hyperplastic changes, particularly in a marked smooth muscle activation. These effects were antagonized by simultaneous, subcutaneous treatment with the aromatase inhibitor 1-methyl-androsta-1,4-diene-3,17-dione (1-Methyl-ADD) and only partially reversed by oral treatment. The serum estradiol (E2) concentration, which was not significantly elevated after treatment with androstenedione in comparison to the control, was drastically decreased after subcutaneous treatment with 1-Methyl-ADD and moderately decreased after oral treatment. In conclusion, these results as well as the great anatomical and histological similarities between the prostate of the cynomolgus monkey and that of man indicate that it might be a suitable and interesting model for future BPH studies.
Improved electrochemical performance of boron-doped carbon-coated lithium titanate as an anode material for sodium-ion batteries (2016)

A boron-doped carbon layer (BC) was coated on porous micron-sized Li<sub>4</sub>Ti<sub>5</sub>O<sub>12</sub>(LTO)<italic>via</italic>a facile wet-chemical method for use as a promising anode material for sodium-ion batteries.