gebhart/patrepeval huggingface dataset:
An All-Digital Phase-Locked Loop with 50-Cycle Lock Time Suitable for High-Performance Microprocessors (1995)

A frequency-synthesizing, all-digital phase-locked loop (ADPLL) is fully integrated with a 0.5 μm CMOS microprocessor. The ADPLL has a 50-cycle phase lock, has a gain mechanism independent of process, voltage, and temperature, and is immune to input jitter. A digitally-controlled oscillator (DCO) forms the core of the ADPLL and operates from 50 to 550 MHz, running at 4× the reference clock frequency. The DCO has 16 b of binarily weighted control and achieves LSB resolution under 500 fs
THERMAL OLIGOMERIZATION OF UNSYMMETRICALLY B-TRISUBSTITUTED BORAZINES (1999)

International audience
Curative effects on rat sarcomas obtained after a treatment combining two monoclonal antibodies (1994)

The effects of a treatment involving two monoclonal antibodies (Ab) were evaluated on benzo(a)pyrene [B(a)P]-induced malignant sarcomas in Sprague-Dawley female rats. These Ab were, respectively, an anti-anti-conjugated B(a)P AB, an internal image of conjugated B(a)P, called AIB1, and an anti-conjugated L-DOPA Ab. They were biweekly injected into animals with small clinically palpable tumors. Anti-'phosphatidylinositol-like' autoantibody (autoAb) levels which were significantly higher in B(a)P-treated rat sera were decreased after Ab treatment. Tumor growth was slowed down compared with that of controls and animal survival was increased. This treatment was more efficient than that involving AIB1 alone. The anti-conjugated L-DOPA Ab may play a role in neovascularization, which is known to be critical for tumor growth.
Strong interaction fairness via randomization (1998)

We present MULTI, a symmetric, distributed, randomized algorithm that, with probability one, schedules multiparty interactions in a strongly fair manner. To our knowledge, MULTI is the first algorithm for strong interaction fairness to appear in the literature. Moreover, the expected time taken by MULTI to establish an interaction is a constant not depending on the total number of processes in the system. In this sense, MULTI guarantees real-time response. MULTI makes no assumptions (other than boundedness) about the time it takes processes to communicate. It, thus, offers an appealing tonic to the impossibility results of Tsay and Bagrodia, and Joung concerning strong interaction fairness in an environment, shared-memory, or message-passing, in which processes are deterministic and the communication time is nonnegligible. Because strong interaction fairness is as strong a fairness condition that one might actually want to impose in practice, our results indicate that randomization may also prove fruitful for other notions of fairness lacking deterministic realizations and requiring real-time response.
On a completely tunable active filter using fixed RC elements (1969)

Linear analog computing elements may be employed to realize a voltage transfer function whose poles and zeros are to be independently controlled. The method is based on the dummy variable technique widely used in analog computer simulation. It requires at most (n + 4) operational amplifiers, n of which are connected as integrators, where n is the degree of the denominator polynomial.
Robot path planning in dynamic environment based on reinforcement learning (2001)

Proposes an adaptive learning method based on reinforcement learning for robot path planning prob lem, which enables the robot to adaptively learn and perform effective path planning, to avoid the moving obsta cles and reach the target. Thereby achieving automatic construction of path planning strategy and making the system adaptive to multi-robots system dynamic environments, and concludes from computer simulation experi ment that the method is powerful to solve the problem of multi-robot path planning, and it is a meaningful try to apply reinforcement learning techniques in multi-robot systems to develop the system's intelligence degree.
Computer Modeling Of Drug Distribution After Intravitreal Administration (2011)

Intravitreal injection (IVI) is the most common treatment for eye posterior segment diseases such as endopthalmitis, retinitis, age-related macular degeneration, diabetic retinopathy, uveitis, and retinal detachment. Most of the drugs used to treat vitreoretinal diseases, have a narrow concentration range in which they are effective, and may be toxic at higher concentrations. Therefore, it is critical to know the drug distribution within the eye following intravitreal injection. Having knowledge of drug distribution, ophthalmologists can decide on drug injection frequency while minimizing damage to tissues. The goal of this study was to develop a computer model to predict intraocular concentrations and pharmacokinetics of intravitreally injected drugs. A finite volume model was created to predict distribution of two drugs with different physiochemical properties in the rabbit eye. The model parameters were obtained from literature review. To validate this numeric model, the in vivo data of spatial concentration profile from the lens to the retina were compared with the numeric data. The difference was less than 5% between the numerical and experimental data. This validation provides strong support for the numerical methodology and associated assumptions of the current study.
PARP Inhibitors and Heart Failure—Translational Medicine Caught in the Act (2007)

With the introduction of this new section, “Spotlight on Heart Failure Translational Research,” Congestive Heart Failure recognizes the importance of the cutting‐edge research that frequently translates to clinical practice in a rapid timeframe. It is the intent of the Co‐Editors in Chief to provide the readership with a window on the future of heart failure therapeutics through the introduction of this section. Dr. George W. Booz, Section Editor for this pivotal area, cordially invites the submission of translational research in all aspects of heart failure for review and potential publication within this section.—John E. Strobeck, MD, PhD and Marc A. Silver, MD, Co‐Editors in Chief
Evaluation of multimedia applications using inspection methods: the Cognitive Walkthrough case (2004)

Many evaluation methods are to be found in research literature: they can be formal, automatic, empirical or informal. The informal methods include so-called inspection methods, which provide a good compromise between the cost and implementation time on the one hand, and the results they make it possible to obtain on the other. Amongst these methods, Cognitive Walkthrough enables the detection of a certain number of usability defects and the estimation of the degree of seriousness of the defect. In this article, we concentrate on Cognitive Walkthrough. We are particularly interested in it because, as far as we know, it is the only method based on theory (the theory of learning through exploration, itself inspired by Norman's Action Theory). However, although its usefulness as regards software ergonomics has been recognised, its efficiency in the case of multimedia applications is still far from being proved and very few research projects have been published on the matter. In fact, multimedia documents have characteristics which differ from those of traditional human-machine systems. This article presents a study on the use of Cognitive Walkthrough for the evaluation of several multimedia applications intended for the general public; it reveals the difficulties met by users and the areas in which the method needs to be adapted.
Enhancing the BRAS through virtualization (2015)

Broadband Remote Access Servers (BRASes) are crucial middleboxes in DSL access networks, providing the first IP point in the network for subscribers and enforcing operator policies. The number of functions provided by BRASes, combined with the key role they play in the network, means that these devices are expensive, difficult to change, and constitute a single point of failure. In order to overcome these limitations, we propose to virtualize the BRAS and to enhance it with a control interface that can be exploited by management systems in order to introduce live session migration and higher reliability. Our proof-of-concept implementation shows that our virtual software BRAS is able to handle thousands of sessions while forwarding and shaping traffic at rates of millions of packets per second on commodity hardware, and that the live session migration feature enables the implementation of high-reliability scenarios.
Designing privacy-friendly digital whiteboards for mediation of clinical progress (2014)

Presenting updated information from patient care activities on a digital whiteboard in a de-identified and abstracted format may support coordination of care at a hospital ward without compromising patient privacy.
Use of Infliximab in Particular Clinical Settings: Management Based on Current Evidence (2009)

With the increasingly widespread use of the anti-tumor necrosis factor-alpha agent infliximab for the treatment of Crohn's disease and ulcerative colitis, there have been some concerns raised about the potential consequences of such therapy in particular clinical settings. In this review, we report the current strategies for optimizing treatment outcomes and minimizing the risks of some of the most serious events attributable to infliximab therapy. In particular, an up-to-date overview is provided on how to treat patients with inflammatory bowel disease using infliximab therapy, with regard to the diagnosis and management of latent tuberculosis infection and the risk of reactivation of hepatitis B and C infections. Furthermore, based on the available evidence, we evaluate the possibility of using infliximab during pregnancy. Finally, we evaluate whether patients with malignancies or pre-neoplastic lesions could be candidates for infliximab therapy. Overall, this review will provide physicians who use infliximab for the treatment of inflammatory bowel disease with several practical recommendations for the management of some complex situations that may occur in daily clinical practice.
Deacylation of Lipopolysaccharide in Whole Escherichia coli during Destruction by Cellular and Extracellular Components of a Rabbit Peritoneal Inflammatory Exudate (1999)

Deacylation of purified lipopolysaccharides (LPS) markedly reduces its toxicity toward mammals. However, the biological significance of LPS deacylation during infection of the mammalian host is uncertain, particularly because the ability of acyloxyacyl hydrolase, the leukocyte enzyme that deacylates purified LPS, to attack LPS residing in the bacterial cell envelope has not been established. We recently showed that the cellular and extracellular components of a rabbit sterile inflammatory exudate are capable of extensive and selective removal of secondary acyl chains from purified LPS. We now report that LPS as a constituent of the bacterial envelope is also subject to deacylation in the same inflammatory setting. Using Escherichia coli LCD25, a strain that exclusively incorporates radiolabeled acetate into fatty acids, we quantitated LPS deacylation as the loss of radiolabeled secondary (laurate and myristate) and primary fatty acids (3-hydroxymyristate) from the LPS backbone. Isolated mononuclear cells and neutrophils removed 50% and 20-30%, respectively, of the secondary acyl chains of the LPS of ingested whole bacteria. When bacteria were killed extracellularly during incubation with ascitic fluid, no LPS deacylation occurred. In this setting, the addition of neutrophils had no effect, but addition of mononuclear cells resulted in removal of >40% of the secondary acyl chains by 20 h. Deacylation of LPS was always restricted to the secondary acyl chains. Thus, in an inflammatory exudate, primarily in mononuclear phagocytes, the LPS in whole bacteria undergoes substantial and selective acyloxyacyl hydrolase-like deacylation, both after phagocytosis of intact bacteria and after uptake of LPS shed from extracellularly killed bacteria. This study demonstrates for the first time that the destruction of Gram-negative bacteria by a mammalian host is not restricted to degradation of phospholipids, protein, and RNA, but also includes extensive deacylation of the envelope LPS.
CT-Guided Stereotactic Aspiration of Intracerebral Hematoma – Result of a Hematoma-Lysis Method Using Urokinase (1985)

CT-guided stereotactic aspiration was performed in the CT room on 97 patients with hypertensive intracerebral hematomas, using a standard ventricular cannula. Residual hematomas were liquefied by urokinase and aspirated through the drainage tube. Major and minor rebleeding were seen in 7 cases. Two out of the 4 major rebleeding cases were followed by craniotomy, while the other cases were treated conservatively. More than 80% of the hematomas were aspirated in 68 cases, 50-70% in 19 cases and 30-40% in 6 cases. Operation in the CT room and hematoma lysis with urokinase is very useful for the aspiration of intracerebral hematomas.
Efficient and damage-resistant tunable cw dye laser (1973)

An analysis of the optical problems encountered in cw dye lasers and various design criteria are presented. On this basis a design which proved to be stable, efficient, and damage resistant is described in detail and some performance data are presented.
Basic fibroblast growth factor experimentally induced choroidal angiogenesis in the minipig (1994)

Basic fibroblast growth factor (bFGF), a soluble mitogen, has been isolated and purified from various organs, including the retina. In vivo angiogenic activity of bFGF has been demonstrated with several assays. An experimental model of choroidal neovascularization was developed in the mini pig by perfusion of recombinant human bFGF through an osmotic minipump. Endogenous bFGF and bFGF receptors were localized in the normal pig retina by immunohistochemistry and autoradiography after binding. The perfusion of exogenous bFGF induced well-organized new vessels along the last 3 mm of the catheter in the suprachoroidal space. This neovascularization did not penetrate the normal Bruch's membrane. Vascular cells (identified by von Willebrand factor antibody staining) increased in number and in surface from the proximal part to the end of the intraocular catheter in all bFGF perfused eyes. In eyes perfused with phosphate buffered saline (controls), but not in the bFGF perfused eyes, an inflammatory response occurred (identified by a macrophage specific antibody). These results demonstrate that choroidal angiogenesis can be achieved without an inflammatory response by perfusing an excess of bFGF in the suprachoroidal space.
Elevation of colony stimulating factors in mouse serum after injection of PSK, an antitumor polysaccharide. (1982)

The level of colony stimulating factors (CSF) in mouse serum was elevated by a single intraperitoneal injection of PSK, a host-mediated antitumor protein-bound polysaccharide obtained from Basidiomycetes. The assay for CSF activity was performed by employing a semisolid methylcellulose culture method using mouse bone marrow cells, and the activity was estimated by an equation well matched with the dose response curve obtained in the CSF assay. A temporary increase of CSF activity within 10 h after the injection of an antitumor polysaccharide, Krestin (PSK) (250-1000 mg/kg) was followed by a fast decline in the activity, but no significant increases were detected in the cases of 62.5 and 125 mg/kg PSK injections. The CSF activity in PSK (500 mg/kg)-treated mouse serum was separated into two active fractions by DEAE ion-exchange chromatography, and both fractions were found to induce colonies comprised of cells with the properties of macrophage in regard to morphology, cytochemistry of non-specific esterase, phagocytic function and expression of Fc receptors on the cell surface. The elevation of the serum CSF level due to administration of so-called host-mediated antitumor agents might be one of the tumor-defense mechanisms in vivo.
Secure and Authenticated Communication in Chip-Level Microcomputer Bus Systems with Tree Parity Machines (2007)

The protection of chip-level microcomputer bus systems in embedded devices is essential to prevent the growing number of hardware hacking attacks. This paper presents an authenticated key exchange and encryption solution in order to ensure chip-level microcomputer bus systems via the tree parity machine rekeying architecture (TPMRA). Due to this intention, a scalable TPMRA IP-core is designed and implemented in order to meet variable bus performance requirements. It allows the authentication of the bus participants as well as the encryption of chip-to-chip buses from a single primitive. The solution is transparent and easy applicable to an arbitrary microcomputer bus system for embedded devices on the market. A proof of concept implementation shows the applicability of the TPMRA in the standardized advanced microprocessor bus architecture (AMBA) by implementing the IP-core into the peripheral bus-to-bus interface (AHB-APB-bridge). It will be shown that the solution is latency free and can be used in order to protect the ARM bus system with a low hardware overhead considering all AMBA bus features.
ChemInform Abstract: SYNTHESIS OF 2,7‐DINITRO‐ AND 2,7‐DIAMINOTHIANTHRENE (1984)

Abstract Diaminothianthren.
Responses of Plants to Environmental Stresses (1973)

Environmental abiotic stresses, such as extreme temperatures, drought, excess light, salinity, and nutrient deficiency, have detrimental effects on plant growth, development, and yield. Plants are equipped with various adaptation mechanisms to cope with such unfavorable conditions. Our understanding of plants’ abiotic stress responses is crucial to maintaining efficient plant productivity. This book on the responses of plants to environmental stresses is an attempt to find answers to several basic questions related to their adaptation and protective mechanisms against abiotic stresses. The following chapters of the book describe examples of plants’ protective strategies, which cover physiological, cellular, biochemical, and genomic mechanisms. This book is aimed for use by advanced students and researchers in the area of stress biology, plant molecular biology and physiology, agriculture, biochemistry, as well as environmental sciences.
Fast nondeterministic random-bit generation using on-chip chaos lasers (2011)

It is shown that broadband chaos suitable for fast nondeterministic random-bit generation in small devices can be achieved in a semiconductor laser with a short external cavity. The design of the device is based on a theoretical model for nondeterministic random-bit generation by amplification of microscopic noise. Moreover, it is demonstrated that bit sequences passing common tests of statistical randomness at rates up to 2.08 Gbits/s can be generated using on-chip lasers with a monolithically integrated external cavity, amplifiers, and a photodetector.
Page description languages: development, implementation and standardization (1988)

SUMMARY Advances in laser technology have facilitated the development of printers which accept input in the form of pages rather than the lines characteristic of impact printers. Concurrently, page description languages (PDLs) have been designed to facilitate the integration of complex text and graphics for printing. PDLs are described in a variety of ways and the paper starts with a rationalization of these viewpoints. It then traces the development of PDLs, describes their main characteristics, and looks at their relationship with laser printers. A survey of current implementations is then followed by an analysis of the relationship of these languages to other schemes for the description of printed images. Finally, the paper considers the requirements for a PDL standard.
Molecular, thermal, and morphological characterization of narrowly branched fractions of 1-octene linear low-density polyethylene. 3. Lamellar and spherulitic morphology (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMolecular, thermal, and morphological characterization of narrowly branched fractions of 1-octene linear low-density polyethylene. 3. Lamellar and spherulitic morphologyF. DeFoor, G. Groeninckx, H. Reynaers, P. Schouterden, and B. Van der HeijdenCite this: Macromolecules 1993, 26, 10, 2575–2582Publication Date (Print):May 1, 1993Publication History Published online1 May 2002Published inissue 1 May 1993https://pubs.acs.org/doi/10.1021/ma00062a028https://doi.org/10.1021/ma00062a028research-articleACS PublicationsRequest reuse permissionsArticle Views247Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Haptic Rendering of Visual Data for the Visually Impaired (2007)

We introduce a force-field haptic rendering method for converting visual data to haptic data. The method includes a novel framework to convert specialized 3D map models into force fields. We generate the final force fields by using structure from motion and implicit surface approximation algorithms. Visually impaired people then can learn to navigate with these maps, using off-the-shelf haptic
Monoclonal antibodies specific for guinea pig eosinophil major basic protein: their use in an ELISA, immunocytochemistry and flow cytometry (1993)

Eosinophil major basic protein (MBP), purified from guinea pig eosinophil granules was used to raise five monoclonal antibodies (MoAbs). Their reactivity with MBP was confirmed by immunoblotting and indirect ELISA. Two of the MoAbs were used to develop a sensitive and specific antigen capture (sandwich) ELISA for guinea pig eosinophil MBP which gives an accurate and reproducible standard curve over the range of 10-10,000 ng/ml. The specificity of the ELISA for MBP was confirmed and its suitability for testing biological samples ascertained by measurement of MBP in bronchoalveolar lavage fluid (BALF) and plasma from guinea pigs sensitized and challenged with ovalbumin. The ELISA was also capable of detecting MBP in culture supernatants from purified eosinophil preparations challenged with calcium ionophore in vitro. One of the monoclonals could be used to strongly and specifically stain guinea pig eosinophils in immunocytochemistry, whilst all five could be used to visualize eosinophils in suspension in BALF or peritoneal lavage fluid by flow cytometry. There was no staining of other guinea pig leucocyte types, nor crossreactivity with human eosinophils by immunocytochemistry or flow cytometry.
Software systems safety and human errors (2003)

The software systems safety discipline is discussed, along with the various areas where human errors impact the design and development of software-controlled systems. Techniques used in software systems safety, as set forth in MIL-STD-882B, are also discussed along with a recommendation for an early, integrated software systems safety and human factors analysis of the software-user interface. The article forms the basis for recommended modifications to Task 306 of MIL-STD-882B.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>