gebhart/patrepeval huggingface dataset:
NLRP3 inflammasome is associated with the response to IFN-β in patients with multiple sclerosis (2015)

Evidence exists for a potential modulation of inflammasome activity by interferon beta. Here, we investigated the roles of inflammasomes [absent in melanoma 2 (AIM2); NLR family, CARD domain containing 4 (NLRC4); NLR family, pyrin domain containing 1 and 3 (NLRP1 and NLRP3)] and related cytokines (IL1B, IL10, IL18) in the response to interferon beta in patients with relapsing-remitting multiple sclerosis. Ninety-seven patients treated with interferon beta were classified into responders and non-responders according to clinical criteria after 24 months and clinical-radiological criteria after 12 months of treatment. Messenger RNA expression levels of inflammasomes and cytokines were determined by real-time polymerase chain reaction in peripheral blood mononuclear cells collected before treatment with interferon beta. In a subgroup of patients, NLRP3 and IL1B expression was also determined after 3 months (n = 32) and 12 months (n = 20) of interferon beta treatment. A polymorphism located in the NLRP3 gene, rs35829419, was genotyped in 789 multiple sclerosis patients treated with interferon beta. Baseline mRNA expression levels for NLRP3 and IL1B were increased in peripheral blood mononuclear cells from non-responders compared to responders classified according to clinical criteria after 24 months (P = 0.02 and P = 0.001, respectively). No significant differences were observed for other inflammasomes and related cytokines. Differences in NLRP3 and IL1B expression remained significant following a clinical-radiological classification after 12 months (P = 0.007 and P = 0.02, respectively). After treatment with interferon beta, NLRP3 and IL1B expression was increased in responders but unchanged in non-responders. A trend for association was observed between rs35829419 and interferon beta response (pM-H = 0.08). These results point to a role of the NLRP3 inflammasome and its related cytokine IL1B in the response to interferon beta in patients with relapsing-remitting multiple sclerosis.
Scalable and Efficient Synthesis of 2′‐Deoxy‐2′‐N‐phthaloyl Nucleoside Phosphoramidites for Oligonucleotide Synthesis. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Biomimicry 1: PC. (1999)

The surface properties of stents can be modified by coating them, for example with a polymer. Phosphorylcoline (PC) is the major component of the outer layer of the cell membrane. The haemo- and biocompatibility of a PC-containing polymer is thus based on biomimicry, and has been confirmed by several experiments showing much reduced thrombogenicity of PC-coated surfaces, and porcine coronary artery implants showing no sign of adverse effect. Clinical experience with the PC-coated BiodivYsio appears favourable. The PC coating can be tailored for take up and controlled elution of various drugs for stent-based local delivery, a property which is being actively explored.
Dependence of and field patterns of surface coils on the electrical properties of the sample and the <scp>MR</scp> operating frequency (2016)

In high field MRI, the spatial distribution of the radiofrequency magnetic ( <b><i>B</i></b><sub>1</sub>) field is usually affected by the presence of the sample. For hardware design and to aid interpretation of experimental results, it is important both to anticipate and to accurately simulate the behavior of these fields. Fields generated by a radiofrequency surface coil were simulated using dyadic Green's functions, or experimentally measured over a range of frequencies inside an object whose electrical properties were varied to illustrate a variety of transmit [Formula: see text] and receive [Formula: see text] field patterns. In this work, we examine how changes in polarization of the field and interference of propagating waves in an object can affect the <b><i>B</i></b><sub>1</sub> spatial distribution. Results are explained conceptually using Maxwell's equations and intuitive illustrations. We demonstrate that the electrical conductivity alters the spatial distribution of distinct polarized components of the field, causing "twisted" transmit and receive field patterns, and asymmetries between [Formula: see text] and [Formula: see text]. Additionally, interference patterns due to wavelength effects are observed at high field in samples with high relative permittivity and near-zero conductivity, but are not present in lossy samples due to the attenuation of propagating EM fields. This work provides a conceptual framework for understanding <b><i>B</i></b><sub>1</sub> spatial distributions for surface coils and can provide guidance for RF engineers.
Thick-film resonant piezo-layers as new gravimetric sensors (1997)

Resonant piezo-layers (RPLs) manufactured in thick-film technology are proposed as highly sensitive gravimetric sensors. RPLs rely on a PZT-based screen printable paste which is used for the fabrication of planar elements on alumina substrates behaving as thickness-mode resonators. When operated at resonance, these elements are sensitive to a mass load applied on their free moving face, working as resonant microbalances with a frequency output, reaching a mass sensitivity of 114 kHz . This paper describes the paste preparation, background theory, frequency-tracking oscillator and the characterization of the sensors and anticipates their application in sensing arrays for chemical measurements.
Desulfurization of Hot Coal-Derived Fuel Gases with Manganese-Based Regenerable Sorbents. 1. Loading (Sulfidation) Tests (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDesulfurization of Hot Coal-Derived Fuel Gases with Manganese-Based Regenerable Sorbents. 1. Loading (Sulfidation) TestsR. Ben-Slimane and M. T. HepworthCite this: Energy Fuels 1994, 8, 6, 1175–1183Publication Date (Print):November 1, 1994Publication History Published online1 May 2002Published inissue 1 November 1994https://pubs.acs.org/doi/10.1021/ef00048a003https://doi.org/10.1021/ef00048a003research-articleACS PublicationsRequest reuse permissionsArticle Views385Altmetric-Citations53LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Intraocular lens power formula based on vergence calculation and lens design (1997)

It is possible to incorporate the exact IOL design into an IOL power calculation formula. Theoretically, the Naeser formula should increase the accuracy of IOL power calculation; however, this has yet to be proved from empirical data. The formula provides an advantage in analysis of postoperative pseudophakia for experimental/scientific purposes because all intraocular distances and powers may be measured or calculated.
Accurate measurement of power system frequency using a digital signal processing technique (1999)

This paper describes the design, computational aspects, and implementation of a digital signal processing technique for measuring the operating frequency of a power system. The technique provides correct and noise-free estimates for near-nominal, nominal, and off-nominal frequencies in about 25 ms, and it requires modest computations. The proposed technique is implemented using a DSP-based board and has been extensively tested using voltage signals obtained from a dynamic frequency source and from a power system. Some test results are presented in the paper.
Hydrogenated Ring-Opened Polynorbornene:  A Highly Crystalline Atactic Polymer (2005)

Ring-opening metathesis polymerization (ROMP) of norbornene with most catalysts produces a polymer with an atactic placement of the cyclopentylene rings, yet partial hydrogenation of this polymer is known to yield a crystalline product. We report here a facile catalytic route to saturate polynorbornene (PN); fully hydrogenated polynorbornene (hPN) is highly crystalline, with an equilibrium melting point estimated as 156 °C. The crystal lattice is monoclinic, with parameters a = 6.936 Å, b = 9.596 Å, c = 12.420 Å, and β = 130.7° at room temperature, indicating nearly complete extension of the hPN backbone within the unit cell. The material remains highly crystalline until the melting point is reached, but near 105 °C, the crystal structure transforms to one characterized by substantial rotational disorder of the hPN chains about their axes, while retaining substantial translational order.
Folding Requirements Are Different between Sterol 14α-Demethylase (CYP51) from Mycobacterium tuberculosis and Human or Fungal Orthologs (2001)

Upon sequence alignment of CYP51 sterol 14alpha-demethylase from animals, plants, fungi, and bacteria, arginine corresponding to Arg-448 of CYP51 in Mycobacterium tuberculosis (MT) is conserved near the C terminus of all family members. In MTCYP51 Arg-448 forms a salt bridge with Asp-287, connecting beta-strand 3-2 with helix J. Deletion of the three C-terminal residues of MTCYP51 has little effect on expression of P450 in Escherichia coli. However, truncation of the fourth amino acid (Arg-448) completely abolishes P450 expression. We have investigated whether Arg-448 has other structural or functional roles in addition to folding and whether its conservation reflects conservation of a common folding pathway in the CYP51 family. Characterization of wild type protein and three mutants, R448K, R448I, and R448A, including examination of catalytic activity, secondary and tertiary structure analysis by circular dichroism and tryptophan fluorescence, and studies of both equilibrium and temporal MTCYP51 unfolding behavior, shows that Arg-448 does not play any role in P450 function or maintenance of the native structure. C-terminal truncation of Candida albicans and human CYP51 orthologs reveals that, despite conservation in sequence, the requirement for arginine at the homologous C-terminal position in folding in E. coli is not conserved. Thus, despite similar spatial folds, functionally related but evolutionarily distinct P450s can follow different folding pathways.
The Development of Autoimmune Inflammatory Arthropathy in Mice Transgenic for the Human T Cell Leukemia Virus Type-1 <i>env-pX</i> Region Is Not Dependent on H-2 Haplotypes and Modified by the Expression Levels of Fas Antigen (1998)

Previously, we reported that human T cell leukemia virus type-1 env-pX region-introduced transgenic (pX-Tg) mice develop an inflammatory polyarthropathy. Although autoimmune pathogenesis was suggested, the detailed mechanisms remain to be elucidated. In this report, we examined effects of the MHC and fas genes on the development of the disease. When pX-Tg mice were backcrossed with different inbred strains, the incidence of arthritis differed among strains; 64% and 72% in BALB/cAn (H-2d), 25% and 46% in C3H/HeN (H-2k), and 0% and 2% in C57BL/6J (H-2b) background at 3 and 6 months of age, respectively. Rheumatoid factor levels in the serum correlated with the susceptibility to the disease, whereas IL-1beta and MHC gene expression were similarly elevated in all of these strains, suggesting involvement of immune regulatory genes in this strain difference. However, introduction of the H-2d locus into C57BL/6J pX-Tg mice did not increase the incidence of arthritis, and substitution of the BALB/cAn H-2 locus with the H-2b did not decrease it. The results indicate that the H-2 locus is not the major determinant of the disease. Then, since previous study indicated a defect in Fas-mediated apoptosis of transgenic T cells, the effects of fas gene modification on the disease were examined. The incidence increased when these pX-Tg mice were crossed with lpr/lpr mice, while it decreased when crossed with fas-transgenic mice. These observations suggest that aberration of Fas-mediated apoptosis of peripheral lymphocytes, rather than negative selection in the thymus, is involved in the development of autoimmune arthropathy in pX-Tg mice.
Three cases of canine leptospirosis in Quebec. (1999)

Three dogs from different locations with acute renal failure were hospitalized in autumn 1996 and 1997. Leptospira interrogans serovar pomona was detected by the microscopic agglutination test. All dogs recovered after antibiotic treatment. The importance of the development of vaccines adapted to emerging serovars in dogs should be addressed.
Nitrogen-vacancy center in diamond: Model of the electronic structure and associated dynamics (2006)

Symmetry considerations are used in presenting a model of the electronic structure and the associated dynamics of the nitrogen-vacancy center in diamond. The model accounts for the occurrence of optically induced spin polarization, for the change of emission level with spin polarization and for new experimental measurements of transient emission. The rate constants given are in variance to those reported previously.
Cloning and sequence analysis of the dnaK gene region of Lactococcus lactis subsp. lactis (1993)

A 5.4 kb HindIII fragment of Lactococcus lactis subsp. lactis was identified using a homologous dnaK probe generated by PCR and cloned in Escherichia coli. Upstream sequences were generated by inverse PCR. The two cloned fragments partially overlapped, and sequencing of 5915 bp revealed the presence of four open reading frames in the order orf1-grpE-dnaK-orf4. orf1 encodes a 39 kDa protein of unknown function which shows considerable sequence homology with the Orf39 and Orfa proteins of Bacillus subtilis and Clostridium acetobutylicum, respectively. The downstream ORFs showed high homology to the grpE and dnaK genes of other prokaryotes. The DnaK protein has a characteristic 24-amino-acid deletion exhibited by all the known DnaK proteins of Gram-positive species. In many bacteria the dnaK and dnaJ genes are found as part of the same operon. The L. lactis dnaK operon is unusual in that the dnaK gene is followed by a putative transcription terminator and a fourth large ORF which shares no homology with the dnaJ genes of other bacteria but has a small degree of homology with various membrane proteins. Vegetative promoter sequences are found upstream of both orf1 and orf4. A 12 bp inverted repeat is found upstream of the putative promoter of orf1 and an 8 bp inverted repeat is found between this promoter and the orf1 initiation codon. These repeats are thought to be involved in regulation of the heat-shock genes. The DnaK homologue is induced approximately 3-fold on heat shock at 42 degrees C.
Effect of oxygen rf-plasma on electronic properties of CNTs (2007)

Multi-wall carbon nanotubes (CNTs) were modified by an oxygen radio frequency plasma treatment, the appropriate duration of which was determined from post-treatment high-resolution transmission electron microscopy (HRTEM) images. A comparison of HRTEM results from gold-decorated pristine and plasma treated CNTs showed that the plasma treatment improves the uniformity of the distribution of surface defects. X-ray photoelectron spectroscopy confirms that oxygen atoms attach to the surface of CNTs. Changes in the C 1s photoemission signal point towards a loss of delocalization of valence electrons, confirmed by the modifications of valence band spectra, and consistent with currently accepted theory.
Steps to Success with the SAS ® Output Delivery System (2008)

Implementation of the Output Delivery System (ODS) has dramatically changed how SAS users can work with their output. This paper provides an overview of how ODS “works” within the SAS System and how you can use it to take your SAS output and “deliver” it to “destinations” such as a PDF, RTF or HTML file. This paper is designed to equip newer users of SAS (or experienced SAS users new to the Output Delivery System) to get started apply ODS functionalities in their reports and projects. After mastering the concepts and techniques discussed in this paper you will be able, with just a few extra commands in your programs, to take your POLDO (Plain Old Listing Destination Output) and convert in to visually-appealing reports without a lot of manual cutting-and-pasting or manual re-entry of SAS-generated output in to other file formats. And, you will have the insights necessary to explore more advanced ODS capabilities that are discussed in many of the references provided at the end of the paper.
The effect of filter material on bioaerosol collection of Bacillus subtilis spores used as a Bacillus anthracis simulant (2005)

The objective of this study was to determine filter materials and extraction methods that are appropriate to use for environmental sampling of B. anthracis. Four types of filters were tested: mixed cellulose ester (MCE) with a pore size of 3 microm, polytetrafluoroethylene (PTFE) with pore sizes of 1 and 3 microm, and gelatin with a pore size of 3 microm. Bacillus subtilis var. niger endospores (also known as Bacillus globigii[BG]) were used as a surrogate for B. anthracis. Endospores were collected into Button Inhalable Aerosol Samplers with sampling times of 15 minutes, 1 hour, and 4 hours. Physical collection efficiency was determined by measuring upstream and downstream B. subtilis concentrations with an optical particle counter. Vortexing with ultrasonic agitation and vortexing with shaker agitation extraction methods were evaluated. The MCE, 1 microm PTFE, and gelatin filters provided physical collection efficiencies of 94% or greater. The 3 microm PTFE filter showed inconsistent physical efficiency characteristics between filters. Epifluorescence microscopic analysis of the gelatin filter extraction fluid revealed the presence of contamination by non-culturable bacteria. Mean differences for microbial culturability were not statistically significant for filter materials and extraction methods. However, the vortexing with shaker agitation extraction method resulted in higher total microbial counts in the extraction fluids for MCE and 1 microm PTFE filters when compared to vortexing with ultrasonic agitation. In summary, the MCE and 1 microm PTFE filters in combination with vortexing and shaker extraction demonstrated the best performance for the filter collection and extraction of BG spores.
Cysteine-Derived <i>S</i>-Protected Oxazolidinones:  Potential Chemical Devices for the Preparation of Peptide Thioesters (2006)

[reaction: see text]. An N-S acyl-transfer-mediated preparation of peptide thioesters using the S-protected oxazolidinone derived from cysteine has been developed and applied to the synthesis of a 32-mer biologically active peptide by native chemical ligation protocols.
Three-Dimensional Particle Tracking Velocimetry Measurement for Bubbly Flow with Digital Color Image Processing (2000)

In this paper we present the study on a three-dimensional PTV measurement of bubbly flow with color digital image processing. The tracers for the liquid motions shine with yellow-green by an ultra-violet illumination. The bubbles are shadow of the incandescent lights with red-colored cellophane sheets. By using six mirrors we lead the image of the test section seen from different three directions to a high-speed color video camera. Color digital image processing makes the bubbles and tracers extracted from background light. We calculate the velocity vectors, trajectories and the three-dimensional characteristics of the bubbles. We reconstruct the whole bubbly flow and present one by OpenGL.
Efficacy of Amitriptyline in the Treatment of Subjective Tinnitus (2001)

We investigated the effect of amitriptyline, a tricyclic antidepressant, on patients with subjective tinnitus. The study group consisted of 37 adult patients admitted to the Ear, Nose, and Throat and Audiology Department of Hacettepe University. The amitriptyline group consisted of 20 patients and the placebo group consisted of 17 patients. All of the patients were evaluated using a questionnaire, audiologic evaluation, high-frequency audiometry, impedancemetric tests, auditory brainstem response, tinnitus frequency, and loudness matching assessed by audiometric methods at the beginning and end of the study. The patients in the amitriptyline group received 50 mg/day amitriptyline in the first week and 100 mg/day for the following 5 weeks. In the placebo group, the patients received tablets consisting of lactose starch for 6 weeks, with a dosage of 1 tablet/day. The subjective complaints of the patients in the amitriptyline group decreased, and the "present" symptoms resulted in fewer complaints. The severity of tinnitus decreased in the amitriptyline group by means of subjective and audiometric methods. In the placebo group, no significant change was observed. The success of treatment was 95% in the amitriptyline group and 12% in the placebo group. Amitriptyline therapy was concluded to be effective.
Analysis of a wet scrubber network in the air remediation of industrial workplaces: benefit for the city air quality (2015)

Industrial activities carried out in confined spaces are characterized by a very specific type of air pollution. The extended exposure to this kind of pollution is often highly harmful, resulting in dramatic effects both on health and safety aspects. The indoor industrial abatement systems, adopted to purify the air, are typically applied to the emission points. The processed air is subsequently emitted outside. In this study we present the experimental results of three-stage wet scrubber systems installed in the industrial workplace of a (i) fiberglass processing plant, where the highest exposure levels to volatile compounds are nowadays today monitored,and of a (ii) waste-to-energy plant, characterized by a very high particulate matter level. The adopted technology, to be used as complementing strategy,does not require special disposal procedures and the processed air is re-emitted in the same work environment for the benefit of the work operators. The operation of the scrubbers network during the working activities, in both the examined environments, has a) reduced the level of volatile compounds by about 40% and b) maintained the particulate matter concentration PM > 1 to a very low level. Industrial plants are disseminated in mega-cities and represent dangerous diffuse pollution emission sources. Remediation of highly polluted industrial plants inside our towns, especially for the conventionally untreated emissions, is of extreme benefit for the cities air quality.
Thoughts on load distribution and the role of programmable switches (2019)

The trend towards powerfully programmable network switching hardware has led to much discussion of the exciting new ways in which it can be used. In this paper, we take a step back, and examine how it should be used.