gebhart/patrepeval huggingface dataset:
Characterization of an Epithelial ∼460-kDa Protein That Facilitates Endocytosis of Intrinsic Factor-Vitamin B12 and Binds Receptor-associated Protein (1997)

By using receptor-associated protein (RAP) as an affinity target, an intrinsic factor-vitamin B12 (IF-B12)-binding renal epithelial protein of approximately 460 kDa was copurified together with the transcobalamin-B12-binding 600-kDa receptor, megalin. IF-B12 affinity chromatography of renal cortex membrane from rabbit and man yielded the same approximately 460-kDa protein. Binding studies including surface plasmon resonance analyses of the protein demonstrated a calcium-dependent and high affinity binding of IF-B12 to a site distinct from the RAP binding site. The high affinity binding of IF-B12 was dependent on complex formation with vitamin B12. Light and electron microscope autoradiography of rat renal cortex cryosections incubated directly with IF-57Co-B12 and rat proximal tubules microinjected in vivo with the radioligand demonstrated binding of the ligand to endocytic invaginations of proximal tubule membranes followed by endocytosis and targeting of vitamin B12 to lysosomes. Polyclonal antibodies recognizing the approximately 460-kDa receptor inhibited the uptake. Immunohistochemistry of kidney and intestine showed colocalization of the IF-B12 receptor and megalin in both tissues. In conclusion, we have identified the epithelial IF-B12-binding receptor as a approximately 460-kDa RAP-binding protein facilitating endocytosis.
Nanodrug Formed by Coassembly of Dual Anticancer Drugs to Inhibit Cancer Cell Drug Resistance (2015)

Carrier-free pure nanodrugs (PNDs) that are composed entirely of pharmaceutically active molecules are regarded as promising candidates to be the next generation of drug formulations and are mainly formulated from supramolecular self-assembly of drug molecules. It benefits from the efficient use of drug compounds with poor aqueous solubility and takes advantage of nanoscale drug delivery systems. Here, a type of all-in-one nanoparticle consisting of multiple drugs with enhanced synergistic antiproliferation efficiency against drug-resistant cancer cells has been created. To nanoparticulate the anticancer drugs, 10-hydroxycamptothecin (HCPT) and doxorubicin (DOX) were chosen as a typical model. The resulting HD nanoparticles (HD NPs) were formulated by a "green" and convenient self-assembling method, and the water-solubility of 10-hydroxycamptothecin (HCPT) was improved 50-fold after nanosizing by coassembly with DOX. The formation process was studied by observing the morphological changes at various reaction times and molar ratios of DOX to HCPT. Molecular dynamics (MD) simulations showed that DOX molecules tend to assemble around HCPT molecules through intermolecular forces. With the advantage of nanosizing, HD NPs could improve the intracellular drug retention of DOX to as much as 2-fold in drug-resistant cancer cells (MCF-7R). As a dual-drug-loaded nanoformulation, HD NPs effectively enhanced drug cytotoxicity to drug-resistant cancer cells. The combination of HCPT and DOX exhibited a synergistic effect as the nanosized HD NPs improved drug retention in drug-resistant cancer cells against P-gp efflux in MCF-7R cells. Furthermore, colony forming assays were applied to evaluate long-term inhibition of cancer cell proliferation, and these assays confirmed the greatly improved cytotoxicity of HD NPs in drug-resistant cells compared to free drugs.
Studies on interaction of isocyanide with transition-metal complexes. 18. Synthesis and reactions of dicobalt octaisocyanide (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudies on interaction of isocyanide with transition-metal complexes. 18. Synthesis and reactions of dicobalt octaisocyanideYasuhiro Yamamoto and Hiroshi YamazakiCite this: Inorg. Chem. 1978, 17, 11, 3111–3114Publication Date (Print):November 1, 1978Publication History Published online1 May 2002Published inissue 1 November 1978https://doi.org/10.1021/ic50189a029RIGHTS & PERMISSIONSArticle Views130Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (543 KB) Get e-Alerts Get e-Alerts
A Credibility-Based Cooperative Spectrum Sensing Technique for Cognitive Radio Systems (2011)

Spectrum sensing is one of the major elements of cognitive radio applications. A single secondary user (SU) usually cannot provide robust sensing capability due to channel effects. In order to overcome this problem, cooperative spectrum sensing techniques have been proposed. Because conventional cooperative spectrum sensing schemes assumed that all sensing nodes have the same sensing reliability, the SUs were assigned identical false-alarm probability even though some of them suffer deep fading, which may degrade their detection performance. In this study, we propose an adaptive credibility-based cooperative spectrum sensing technique, which evaluates the sensing reliability of SUs based on previous sensing performance, and adjusts the probability of false alarm of each SU individually. Assigning a higher false alarm probability for a more reliable SU can result in better detection performance. To verify the effectiveness of the proposed cooperative spectrum sensing technique, both the false alarm probability and the detection probability are simulated under Rayleigh fading channels, and the results show that the proposed approach outperforms any conventional detection method in terms of detection performance.
Autoinjector Device for Rapid Administration of Life Saving Drugs in Emergency (2012)

A number of emergency situations require immediate drug administration for reducing the morbidity and mortality. Autoinjectors are very useful devices for the rapid administration of the recommended drugs. They are well suited for emergency and mass casualty management, convenient to use and fast in action. A variety of autoinjectors are available viz., for nerve agent poisoning (atropine sulphate and pralidoxime chloride), anaphylactic shock (epinephrine), seizures (diazepam), and migraine (sumatriptan). The advantages of these autoinjectors are reviewed here with a focus on the requirement for autoinjectors for an antibacterial and an analgesic drug. Defence Science Journal, 2012, 62(5), pp.307-314 , DOI:http://dx.doi.org/10.14429/dsj.62.2317
The Pharmacological Basis of Drug Interactions (1971)

Drug interactions become more likely with the increased use of polypharmacy. Some interactions such as those employed by anesthetists are useful, but others can be dangerous. The pharmacological principles involved are discussed with the aid of diagrams and tables, and the mechanisms of drug interactions are outlined. A brief review of interactions related to anesthesia and surgery is included.
Gibberellic Acid-Enhanced Synthesis and Release of α-Amylase and Ribonuclease by Isolated Barley and Aleurone Layers (1967)

Gibberellic acid enhances the synthesis of alpha-amylase in isolated aleurone layers of barley-seeds (Hordeum vulgare var. Himalaya). In the presence of 20 mm calcium chloride the amount of enzyme obtained from isolated aleurone layers is quantitatively comparable to that of the half-seeds used in earlier studies. After a lag period of 6 to 8 hours enzyme is produced at a linear rate. Gibberellic acid does not merely trigger alpha-amylase synthesis, but it is continuously required during the period of enzyme formation. Enzyme synthesis is inhibited by inhibitors of protein and RNA synthesis. Small amounts of actinomycin D differentially inhibit enzyme release and enzyme synthesis suggesting 2 distinct processes. Gibberellic acid similarly enhances the formation of ribonuclease which increases linearly over a 48 hour period. During the first 24 hours the enzyme is retained by the aleurone cells and this is followed by a rapid release of ribonuclease during the next 24 hour period. The capacity to release the enzyme is generated between 20 and 28 hours after the addition of the hormone. Ribonuclease formation is inhibited by inhibitors of protein and RNA synthesis. These inhibitors also prevent the formation of the release mechanism if added at the appropriate moment.
Discovering communities in complex networks by edge label propagation (2016)

The discovery of the community structure of real-world networks is still an open problem. Many methods have been proposed to shed light on this problem, and most of these have focused on discovering node community. However, link community is also a powerful framework for discovering overlapping communities. Here we present a novel edge label propagation algorithm (ELPA), which combines the natural advantage of link communities with the efficiency of the label propagation algorithm (LPA). ELPA can discover both link communities and node communities. We evaluated ELPA on both synthetic and real-world networks, and compared it with five state-of-the-art methods. The results demonstrate that ELPA performs competitively with other algorithms.
Solution Conformations and Dynamics of ABL Kinase-Inhibitor Complexes Determined by NMR Substantiate the Different Binding Modes of Imatinib/Nilotinib and Dasatinib (2008)

Current structural understanding of kinases is largely based on x-ray crystallographic studies, whereas very little data exist on the conformations and dynamics that kinases adopt in the solution state. ABL kinase is an important drug target in the treatment of chronic myelogenous leukemia. Here, we present the first characterization of ABL kinase in complex with three clinical inhibitors (imatinib, nilotinib, and dasatinib) by modern solution NMR techniques. Structural and dynamical results were derived from complete backbone resonance assignments, experimental residual dipolar couplings, and (15)N relaxation data. Residual dipolar coupling data on the imatinib and nilotinib complexes show that the activation loop adopts the inactive conformation, whereas the dasatinib complex preserves the active conformation, which does not support contrary predictions based upon molecular modeling. Nanosecond as well as microsecond dynamics can be detected for certain residues in the activation loop in the inactive and active conformation complexes.
Unicompartmental tibiofemoral resurfacing arthroplasty. (1978)

Citric acid (CA) was evaluated as a functionality-enhancing monomer in biobased polyesters suitable for coating applications. Model reactions of CA with several primary and secondary alcohols and diols, including the 1,4:3,6-dianhydrohexitols, revealed that titanium(IV) n-butoxide catalyzed esterification reactions involving these compounds proceed at relatively low temperatures, often via anhydride intermediates. Interestingly, the facile anhydride formation from CA at temperatures around CA's melting temperature (Tm = 153 °C) proved to be crucial in modifying sterically hindered secondary hydroxyl end groups. OH-functional polyesters were reacted with CA in the melt between 150 and 165 °C, yielding slightly branched carboxylic acid functional materials with strongly enhanced functionality. The acid/epoxy curing reaction of the acid-functional polymers was simulated with a monofunctional glycidyl ether. Finally, the CA-modified polyesters were applied as coatings, using conventional cross-linking agents. The formulations showed rapid curing, resulting in chemically and mechanically stable coatings. These results demonstrate that citric acid can be applied in a new way, making use of its anhydride formation to functionalize OH-functional polyesters, which is an important new step toward fully biobased coating systems.
Thomas-Fermi type theories for polymers and thin films (2000)

We define a Thomas-Fermi-von Weizsäcker model for polymers and thin films through a thermodynamic limit process. Our argument makes use of standard techniques for elliptic PDEs, such as maximum principles or supersolution methods. In the course of our work, we establish some existence and uniqueness results for a system of nonlinear PDEs.
New Analogues of the Anticancer E7070: Synthesis and Pharmacology (2003)

Cell cycle control in the G1 phase has attracted considerable attention in recent cancer research, because many of the important proteins involved in G1 progression or G1/S transition have been found to play a crucial role in proliferation, differentiation, transformation, and programmed cell death (apoptosis). E7070 is a novel antitumor sulfonamide, with a unique mode of action that affects G1 progression of the cell cycle. A series of compounds containing an N-[1-(3,4,5-trimethoxybenzyl)-1H-indol-5-yl]benzene sulfonamide, analogues of E7070, was synthesized and evaluated as potential antitumor agents. Cell cycle analysis with PC3 human prostate cancer cells revealed a cellular accumulation in the G1 phase.
Effects of Substituents and Substitution Positions on Alkaline Stability of Imidazolium Cations and Their Corresponding Anion-Exchange Membranes (2014)

Imidazolium cations with butyl groups at various substitution positions (N1-, C2-, and N3-), 1-butyl-2,3-dimethylimidazolium ([N1-BDMIm](+)), 2-butyl-1,3-dimethylimidazolium ([C2-BDMIm](+)), and 3-butyl-1,2-dimethylimidazolium ([N3-BDMIm](+)), were synthesized. Quantitative (1)H NMR spectra and density functional theory calculation were applied to investigate the chemical stability of the imidazolium cations in alkaline solutions. The results suggested that the alkaline stability of the imidazolium cations was drastically affected by the C2-substitution groups. The alkaline stability of imidazolium cations with various substitution groups at the C2-position, including 2-ethyl-1-butyl-3-methylimidazolium ([C2-EBMIm](+)), 1,2-dibutyl-3-methylimidazolium ([C2-BBMIm](+)), and 2-hydroxymethyl-1-butyl-3-methylimidazolium ([C2-HMBMIm](+)), was further studied. The butyl group substituted imidazolium cation ([C2-BBMIm](+)) exhibited the highest alkaline stability at the elevated temperatures. The synthesized anion-exchange membranes based on the [C2-BBMIm](+) cation showed promising alkaline stability. These observations should pave the way to the practical application of imidazolium-based anion exchange membrane fuel cells.
Dynamic cache reconfiguration and partitioning for energy optimization in real-time multi-core systems (2011)

Multicore architectures, especially chip multi-processors, have been widely acknowledged as a successful design paradigm. Existing approaches primarily target application-driven partitioning of the shared cache to alleviate inter-core cache interference so that both performance and energy efficiency are improved. Dynamic cache reconfiguration is a promising technique in reducing energy consumption of the cache subsystem for uniprocessor systems. In this paper, we present a novel energy optimization technique which employs both dynamic reconfiguration of private caches and partitioning of the shared cache for multicore systems with real-time tasks. Our static profiling based algorithm is designed to judiciously find beneficial cache configurations (of private caches) for each task as well as partition factors (of the shared cache) for each core so that the energy consumption is minimized while task deadline is satisfied. Experimental results using real benchmarks demonstrate that our approach can achieve 29.29% energy saving on average compared to systems employing only cache partitioning.
Analysis and Implementation of a High Efficiency, Interleaved Current-Fed Full Bridge Converter for Fuel Cell System (2007)

An interleaved current-fed full bridge (ICFFB) dc-dc converter is proposed in this paper that has low input current ripple to meet the fuel cell demands. By interleaving two isolated CFFB converters with parallel input and series output connection, both input current ripple and output voltage ripple can be reduced. In addition, the size of the magnetic components and current stress of the semiconductor devices on the input side are also reduced. Similarly, smaller voltage rating components can be used on the output side. Only one digital signal processor microcontroller is used to generate phase-shifted gate signals and to implement a cascaded digital control system. The main features of the proposed converter are high efficiency, small passive component size, and small input current ripple. Experimental results for a 1.2-kW interleaved CFFB converter are provided in the paper
A 1 V 2.2 mW 7 GHz CMOS Quadrature VCO Using Current-Reuse and Cross-Coupled Transformer-Feedback Technology (2008)

A current-reused quadrature voltage-controlled oscillator (CR-QVCO) is proposed with the cross-coupled transformer-feedback technology for the quadrature signal generation. This CR-QVCO has the advantages of low-voltage/low-power operation with an adequate phase noise performance. A compact differential three-port transformer, in which two half-circle secondary coils are carefully designed to optimize the effective turn ratio and the coupling factor, is newly constructed to satisfy the need of signal coupling and to save the area consumption simultaneously. The quadrature oscillator providing a center frequency of 7.128 GHz for the ultrawideband (UWB) frequency synthesizer use is demonstrated in a 0.18 mum RF CMOS technology. The oscillator core dissipates 2.2 mW from a 1 V supply and occupies an area of 0.48 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . A tuning range of 330 MHz (with a maximum control voltage of 1.8 V) can be achieved to stand the frequency shift caused by the process variation. The measured phase noise is -111.2 dBc/Hz at 1 MHz offset from the center frequency. The IQ phase error shown is less than 2deg. The calculated figure-of-merit (FOM) is 184.8 dB.
Use of a Novel Penetrating, Sutureless Anastomotic Device in Arterial Microvascular Anastomoses (2008)

The advent of microsurgery and microvascular anastomosis has helped to alter the treatment of many traumatic defects as well as revolutionize the reconstructive options after extirpative surgery. These procedures, however, continue to be technically demanding and intensive. In addition, increased ischemia and operative times are known to raise complications in microsurgery, particularly in older patients. The nitinol U-clip (Medtronic, Inc., Minneapolis, MN) is a new penetrating clip applied in an interrupted fashion that eliminates knot tying and decreases operative time. This technology holds the potential for rapid, reproducible sutureless microvascular anastomoses. In addition, the surgical technique is very similar to conventional suture microanastomosis, lending itself to comparatively decreased learning curves and suitability for training programs. We present three consecutive cases of successful microsurgical anastomoses using this technology.
Protective antiviral antibody responses in a mouse model of influenza virus infection require TACI (2011)

Antiviral Abs, for example those produced in response to influenza virus infection, are critical for virus neutralization and defense against secondary infection. While the half-life of Abs is short, Ab titers can last a lifetime due to a subset of the Ab-secreting cells (ASCs) that is long lived. However, the mechanisms governing ASC longevity are poorly understood. Here, we have identified a critical role for extrinsic cytokine signals in the survival of respiratory tract ASCs in a mouse model of influenza infection. Irradiation of mice at various time points after influenza virus infection markedly diminished numbers of lung ASCs, suggesting that they are short-lived and require extrinsic factors in order to persist. Neutralization of the TNF superfamily cytokines B lymphocyte stimulator (BLyS; also known as BAFF) and a proliferation-inducing ligand (APRIL) reduced numbers of antiviral ASCs in the lungs and bone marrow, whereas ASCs in the spleen and lung-draining lymph node were surprisingly unaffected. Mice deficient in transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI), a receptor for BLyS and APRIL, mounted an initial antiviral B cell response similar to that generated in WT mice but failed to sustain protective Ab titers in the airways and serum, leading to increased susceptibility to secondary viral challenge. These studies highlight the importance of TACI signaling for the maintenance of ASCs and protection against influenza virus infection.
Improved sectorised antenna for indoor localization systems (2011)

This paper presents a switched beam antenna suitable for localization systems operating on 2.4–2.5 GHz ISM band. The antenna is used in a system based on a wireless sensor network, and will be used for implementing Angle of Arrival (AoA) techniques combined with RF fingerprinting solutions. The proposed antenna, called Hive 5, is based on a sectorised design integrated with patch-excited horn antennas carefully designed to provide an improved radiation pattern and Axial Ratio (AR) in order to improve the system performance. This antenna provides a low cost solution for localization systems in indoor environments with gain improvement, reduced coupling between neighbor antennas and increased multipath rejection.
Efficacy and safety of dulaglutide in patients with type 2 diabetes: a meta-analysis and systematic review (2016)

A meta-analysis was conducted to assess the clinical efficacy and safety of dulaglutide in patients with type 2 diabetes mellitus (T2DM). Medline, Embase, Cochrane Library and www. clinicaltrials. gov (up to February 15(th), 2015) were searched. Randomized controlled trials comparing dulaglutide to other drugs for T2DM were collected. Twelve RCTs were included, and the overall bias was low. As the monotherapy, compared with control (placebo, metformin and liraglutide), dulaglutide resulted in a significant reduction in HbA1c (WMD, -0.68%; 95% CI, -0.95 to -0.40), FPG (WMD, -0.90 mmol/L; 95% CI, -1.28 to -0.52), a similar risk of hypoglycemia (7.8% vs. 10.6%), less body weight loss (WMD, 0.51 kg; 95% CI, 0.27 to 0.75). As an add-on intervention with oral antihyperglycemic medication (OAM) and insulin, compared with control (placebo, sitagliptin, exenatide, liraglutide and glargine), dulaglutide lowered HbA1c (WMD, -0.51%; 95% CI, -0.68 to -0.35) and body weight significantly (WMD, -1.30 kg, 95% CI, -1.85 to -1.02) notably, and elicited a similar reduction in FPG (WMD, -0.19 mmol/L; 95% CI, -1.20 to 0.82), an similar incidence of hypoglycemia (24.5% vs. 24.5%). This meta-analysis revealed the use of dulaglutide as a monotherapy or an add-on to OAM and lispro appeared to be effective and safe for adults with T2DM.