gebhart/patrepeval huggingface dataset:
N-acetylcysteine inhibits endothelial cell invasion and angiogenesis. (1999)

The thiol N-acetylcysteine (NAC) is a chemopreventive agent that acts through a variety of mechanisms and can prevent in vivo carcinogenesis. We have previously shown that NAC inhibits invasion and metastasis of malignant cells as well as tumor take. Neovascularization is critical for tumor mass expansion and metastasis formation. We investigated whether a target of the anti-cancer activity of NAC could be the inhibition of the tumor angiogenesis-associated phenotype in vitro and in vivo using the potent angiogenic mixture of Kaposi's sarcoma cell products as a stimulus. Two endothelial (EAhy926 and human umbilical vein endothelial [HUVE]) cell lines were utilized in a panel of assays to test NAC ability in inhibiting chemotaxis, invasion, and gelatinolytic activity in vitro. NAC treatment of EAhy926 and HUVE cells in vitro dose-dependently reduced their ability to invade a reconstituted basement membrane, an indicator of endothelial cell activation. Invasion of HUVE cells was inhibited with an ID50 of 0.24 mM NAC, whereas inhibition of chemotaxis required a 10 fold higher doses, indicating that invasion is a preferential target. NAC inhibited the enzymatic activity and conversion to active forms of the gelatinase produced by endothelial cells. The matrigel in vivo assay was used for the evaluation of angiogenesis; NAC strongly inhibited neovascularization of the matrigel sponges in response to Kaposi's sarcoma cell products. NAC prevented angiogenesis while preserving endothelial cells, implying that it could be safely used as an anti-angiogenic treatment.
Techniques for automated network map generation using SNMP (2002)

Network configuration information is useful in producing a visual map of the network complete in all details. The visual map is an essential component for network management and operations. It is also possible to generate an inventory report of a network. The inventory report describes the nodes, networks, interfaces, addresses, protocols, speeds, etc. and is a valuable component for network planning and administration. Unfortunately, network management is severely constrained in scope and effectiveness by the lack of any organized pool of network configuration information. We present results of our efforts to develop tools and techniques for automatically and mechanically synthesizing network configuration related information from the Internet. These techniques, we believe, will be instrumental in, generating the pool of network configuration information.
The United States of America (2001)

There were two changes in the Clinton cabinet during 2000. In the first, Secretary of Commerce William Daley resigned in June to replace Tony Coelho as the head of the Gore presidential campaign. He was replaced by former congressman NormanMineta. The other change came in July, when Secretary of Veterans Affairs Togo West, whose two-year tenure had seen significant charges of mismanagement, resigned to return to the private sector. Hershel Gober became acting secretary.
Surface activated bonding of 8 in. Si wafers for MEMS and microfluidic packaging (2009)

The challenges for direct wafer bonding using surface activated bonding (SAB) method have been investigated. For this purpose, 4-8 in silicon wafers with and without fine patterns were bonded in vacuum. Three challenges are identified through comprehensive investigations of the bonded interfaces using infrared (IR) transmission, tensile pulling, and high-resolution transmission electron microscopy (HRTEM) observation. First is the alignment between the wafers. While the alignment accuracy is about 5 mum before contacting the wafers, it becomes about 17 mum after bonding. Second are the air-gaps across the bonded interface due to processing induced artifacts and particles. Third is the wafer bow, which control the three-dimensional (3D) bonding. Three-bulk Si 8 inch wafers were bonded together for 3D bonding. Thin wafers with small bow are recommended for 3D bonding using the SAB method.
Synthesis and Diatropicity of <i>trans</i>-2‘,5‘,10b,10c-Tetramethylfurano[3,4-<i>e</i>]-10b,10c-dihydropyrene. A Valence Isomerization To Form a Novel Isoannulenofuran at the Expense of Two Benzene and One Furan Rings (1996)

The 1,4-dicarbonyl compound 22 was prepared by an oxidative coupling of the benzyl methyl ketone 19. Dehydration of 22 gave the 3,4-diarylfuran 16 which upon functional group transformations and a subsequent intramolecular cyclization afforded only the anti isomer of the furanothiacyclophane 27. Ring contraction following a Wittig rearrangement−Hofmann elimination sequence led to the isolation of anti furanocyclophanene 15b. Valence isomerization of 15b to the isoannulenofuran 14b could be achieved either photochemically or thermally with 15b as the thermodynamically more stable isomer. Compound 14b was found to exhibit only a very small ring current. The diatropicity of 14b is clearly affected by a weak participation of the oxygen in π-electron delocalization and a steric effect of its external methyl groups resulting in a deviation from planarity of its molecular periphery. The thermal conversion of 15b to 14b was determined to have a high activation energy of 114 kJ mol-1. This thermal process, in addition to involving the disruption of π-electron delocalization in two benzene and one furan rings, is another example of an unsual concerted, symmetry-forbidden reaction.
A Hardware-Software Codesign Approach to Identity, Trust, and Resilience for IoT/CPS at Scale (2019)

Advancement in communication technologies and the Internet of Things (IoT) is driving adoption in smart cities that aims to increase operational efficiency and improve the quality of services and citizen welfare, among other potential benefits. The privacy, reliability, and integrity of communications must be ensured so that actions can be appropriate, safe, accurate, and implemented promptly after receiving actionable information. In this work, we present a multi-tier methodology consisting of an authentication and trust-building/distribution framework designed to ensure the safety and validity of the information exchanged in the system. Blockchain protocols and Radio Frequency-Distinct Native Attributes (RF-DNA) combine to provide a hardware-software codesigned system for enhanced device identity and overall system trustworthiness. Our threat model accounts for counterfeiting, breakout fraud, and bad mouthing of one entity by others. Entity trust (e.g., IoT devices) depends on quality and level of participation, quality of messages, lifetime of a given entity in the system, and the number of known "bad" (non-consensus) messages sent by that entity. Based on this approach to trust, we are able to adjust trust upward and downward as a function of real-time and past behavior, providing other participants with a trust value upon which to judge information from and interactions with the given entity. This approach thereby reduces the potential for manipulation of an IoT system by a bad or byzantine actor.
Revision of the Wechsler Memory Scale-Fourth Edition of Chinese version (adult battery) (2015)

目的:修订韦克斯勒记忆量表第四版(WMS-Ⅳ)中文版(成人版),并考察其效度和信度.方法:将全国16岁以上人口作为取样总体,以年龄、性别、教育程度为主要变量按比例分层取样,选取16 ～ 69岁有效样本1561人,应用WMS-Ⅳ中文版(成人版)对样本进行个别记忆测验.该量表包括5个基本分量表(逻辑记忆、词语配对、图形重置、视觉再现、空间叠加),用于导出5个指数分;还包含1个简明认知状况测验的可选分量表.同时施测韦氏成人智力量表第四版(WAIS-Ⅳ)中文版来检验效标效度.选取样本中95名被试间隔22天后重测WMS-Ⅳ中文版(成人版).结果:验证性因子分析表明量表的二因素结构拟合较好(x2/df=14.77/4,RMSEA=0.04,NFI=0.99,NNFI=0.99,RFI =0.99,AGH=0.99,SRMR=0.02);各指数分与WAIS-Ⅳ中文版工作记忆指数的相关系数为0.50 ～ 0.64,各指数分及总记忆商与总智商的相关系数为0.61 ～0.73(均P＜0.05).各分量表得分、过程分、指数分及总记忆商的平均信度系数分别为0.79 ～0.93、0.67 ～0.86、0.93～ 0.97;分量表得分、指数分及总记忆商的重测信度分别为0.40 ～0.69、0.68 ～0.76、0.78;各再认分量表分类判定的一致性系数均＞0.90;评分者一致性＞0.95.结论:WMS-Ⅳ中文版(成人版)具有良好的效度和信度,可以在中国成人群体中进行应用.
Chemoprevention of Breast Cancer (1997)

Abstract: The need for breast cancer chemoprevention is introduced. Evidence for chemopreventive activity has been provided by a decrease in the prevalence of contralateral breast cancer in large adjuvant trials of tamoxifen or fenretinide versus placebo. The NSABP tamoxifen prevention trial in high-risk women is nearing completion. Before other large phase III trials are initiated, phase II trials should be conducted using morphologic and molecular markers as indicators of response (surrogate endpoint biomarkers). Phase II models currently utilized include: (a) a short-interval trial between biopsy and re-excision in women with DCIS; and (b) a longer interval trial in which high-risk women with epithelial hyperplasia and atypia noted on random fine-needle aspiration receive drug or placebo for 6 months and are then reaspirated. Strengths and weaknesses of both models used in ongoing phase II trials are discussed.
A Preliminary Method of Abnormal Pattern Recognition (APR) Based on Adaptive Slide Window (ASW) and Template Matching(TM) (2021)

Due to the high complexity, large volume, and variability of big data, traditional data detection methods are no longer suitable. Aiming at these characteristics, this paper proposes a preliminary method of APR, which uses ASW and TM to detect change points. This method uses the combination of the TSTKS algorithm and ASW to realize rapid detection of multiple change-points in time series data, extract continuous multi-window fluctuation characteristics, construct a normalized fluctuation vector of time series data, and perform abnormal state detection on large-scale disease signals and analysis. Experimental results such as simulation data and EEG signal analysis show that this APR has the advantages of short specific detection time and higher accuracy rate, and is suitable for the detection and analysis applied to large data.
Endogenous Expression of Activation-Induced Cytidine Deaminase in Cell Line WEHI-231 (2004)

Because of its susceptibility to apoptosis on Ag receptor cross-linking, cells of the mouse cell line WEHI-231 have been classified as immature B cells. Surprisingly, however, the cell line expresses activation-induced cytidine deaminase, the enzyme that mediates hypermutation and Ig class switch recombination in activated B cells. Although both cDNA sequence and protein expression of activation-induced cytidine deaminase appear normal, the cell line does not hypermutate an indicator plasmid. For the readout, the indicator plasmid depends on the removal of deoxyuridine after transition from C to U and, therefore, on functional expression of uracil N-glycosylase 2, which is normal in WEHI-231. At the endogenous Ig locus, however, WEHI-231 does undergo the canonical hypermutation of G. C to A. T base pairs to some extent. The cell line also expresses the germline transcripts of the Ig gamma 2b, epsilon, and alpha loci, but it does not switch its IgM surface Ig.
Krzysztof Wodiczko's "Homeless Projection" and the Site of Urban "Revitalization" (1986)

For all that has gone wrong here, there are still reminders within the square itself of what a grand civic environment this once was. There are bronze fountains and some of the city's finest statuary. The best of the statues are Henry Kirke Brown and John Quincy Ward's equestrian statue of Washington, with a Richard Upjohn base, and Karl Adolf Donndorf's mother and children atop a bronze fountain base. There is also an immense flagstaff base, 9 Y2 feet high and 36 feet in diameter, with bas-reliefs by Anthony de Francisci symbolizing the forces of good and evil in the Revolutionary War; even if a derelict is relieving himself beside it, it has a rather majestic presence. 1
In vitro antibacterial effect of carbamide peroxide on oral biofilm (2013)

This study compared the effects of carbamide peroxide (CP) and chlorhexidine (CHX) on oral biofilm in vitro. Collagen-coated hydroxyapatite discs were inoculated with subgingival plaque. After 3 weeks, the emergent biofilms were subjected to 1-, 3-, and 10-min exposures of a 1% CHX gel, a 5% CP gel and rinse, and a 10% CP gel and rinse. Subsequently, the biofilms were stained using a two-colour fluorescent dye kit for confocal laser scanning microscopy, and the volume ratio of dead bacteria to all bacteria was analysed. Compared to a non-treated gel control, the active agents killed bacteria on all the discs, with higher concentration and longer exposure times killing more bacteria. The rinse form disrupted the biofilm quicker than the gel form. Overall, 10% CP showed more disruption of biofilm and a greater proportion of killed bacteria than 1% CHX (p<0.05).
The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver (2009)

Genome-wide association studies have identified a number of signals for both Type 2 Diabetes and related quantitative traits. For the majority of loci, the transition from association signal to mutational mechanism has been difficult to establish. Glucokinase (GCK) regulates glucose storage and disposal in the liver where its activity is regulated by glucokinase regulatory protein (GKRP; gene name GCKR). Fructose-6 and fructose-1 phosphate (F6P and F1P) enhance or reduce GKRP-mediated inhibition, respectively. A common GCKR variant (P446L) is reproducibly associated with triglyceride and fasting plasma glucose levels in the general population. The aim of this study was to determine the mutational mechanism responsible for this genetic association. Recombinant human GCK and both human wild-type (WT) and P446L-GKRP proteins were generated. GCK kinetic activity was observed spectrophotometrically using an NADP(+)-coupled assay. WT and P446L-GKRP-mediated inhibition of GCK activity and subsequent regulation by phosphate esters were determined. Assays matched for GKRP activity demonstrated no difference in dose-dependent inhibition of GCK activity or F1P-mediated regulation. However, the response to physiologically relevant F6P levels was significantly attenuated with P446L-GKRP (n = 18; P <or= 0.03). Experiments using equimolar concentrations of both regulatory proteins confirmed these findings (n = 9; P < 0.001). In conclusion, P446L-GKRP has reduced regulation by physiological concentrations of F6P, resulting indirectly in increased GCK activity. Altered GCK regulation in liver is predicted to enhance glycolytic flux, promoting hepatic glucose metabolism and elevating concentrations of malonyl-CoA, a substrate for de novo lipogenesis, providing a mutational mechanism for the reported association of this variant with raised triglycerides and lower glucose levels.
Differential Response of Respiratory Dendritic Cell Subsets to Influenza Virus Infection (2008)

Dendritic cells (DC) are believed to play an important role in the initiation of innate and adaptive immune responses to infection, including respiratory tract infections, where respiratory DC (RDC) perform this role. In this report, we examined the susceptibilities of isolated murine RDC to influenza virus infection in vitro and the effect of the multiplicity of infection (MOI) on costimulatory ligand upregulation and inflammatory cytokine/chemokine production after infection. We found that the efficiency of influenza virus infection of RDC increased with increasing MOIs. Furthermore, distinct subpopulations of RDC differed in their susceptibilities to influenza virus infection and in the magnitude/tempo of costimulatory ligand expression. Additional characterization of the CD11c-positive (CD11c(+)) RDC revealed that the identifiable subsets of RDC differed in susceptibility to infection, with CD11c(+) CD103(+) DC exhibiting the greatest susceptibility, CD11c(+) CD11b(hi) DC exhibiting intermediate susceptibility, and CD11c(+) B220(+) plasmacytoid DC (pDC) exhibiting the least susceptibility to infection. A companion analysis of the in vivo susceptibilities of these RDC subsets to influenza virus revealed a corresponding infection pattern. The three RDC subsets displayed different patterns of cytokine/chemokine production in response to influenza virus infection in vitro: pDC were the predominant producers of most cytokines examined, while CD103(+) DC and CD11b(hi) DC produced elevated levels of the murine chemokine CXCL1 (KC), interleukin 12p40, and RANTES in response to influenza virus infection. Our results indicate that RDC are targets of influenza virus infection and that distinct RDC subsets differ in their susceptibilities and responses to infection.
The Piazza peer data management project (2003)

A major problem in today's information-driven world is that sharing heterogeneous, semantically rich data is incredibly difficult. Piazza is a peer data management system that enables sharing heterogeneous data in a distributed and scalable way. Piazza assumes the participants to be interested in sharing data, and willing to define pairwise mappings between their schemas. Then, users formulate queries over their preferred schema, and a query answering system expands recursively any mappings relevant to the query, retrieving data from other peers. In this paper, we provide a brief overview of the Piazza project including our work on developing mapping languages and query reformulation algorithms, assisting the users in defining mappings, indexing, and enforcing access control over shared data.
Immune rejection of metastases arising from intraocular tumors in mice. (1986)

The role of the immune response in the elimination of spontaneous metastases arising from intraocular tumors was examined in a syngeneic intraocular murine tumor model. P91 mastocytoma (DBA/2 origin) expresses strong tumor-specific transplantation antigens and grows transiently in the eyes of syngeneic hosts before undergoing spontaneous rejection. An organ culture technique was used to detect spontaneous metastases in the lungs, spleens, brains, and thymuses of intraocular tumor-bearing mice. Metastatic tumor cells were detected in all organs of immunodeficient mice (i.e., athymic, nude, or x-irradiated DBA/2 mice) within 14 days of intraocular transplantation, and grew progressively thereafter. By contrast, metastatic tumors were rejected in 100% of the immunocompetent DBA/2 mice examined on day 15. Timed enucleation experiments demonstrated that the immune rejection of disseminated tumor cells occurred within 24-48 hr of their arrival at the various organs. The immune rejection of spontaneous metastases could be adoptively transferred to immunodeficient tumor-bearing mice using spleen cells, but not immune serum, from intraocular tumor-bearing immunocompetent donors. Selective cell depletion experiments revealed that the immune spleen cell effecting immunity was an Lyt 1+, 2+ T cell. The results indicate that the immune rejection of the spontaneous metastases arising from primary intraocular tumors is a T cell-dependent, radiosensitive process that rapidly eliminates metastases within the lungs, brain, thymus, and the spleen of the immunocompetent host.
Data mining for improving a cleaning process in the semiconductor industry (2002)

As device geometry continues to shrink, micro-contaminants have an increasingly negative impact on yield. By diminishing the contamination problem, semiconductor manufacturers will significantly improve wafer yield. This paper presents a comprehensive and successful application of data mining methodologies to the refinement of a new dry cleaning technology that utilizes a laser beam for the removal of micro-contaminants. Experiments with three classification-based data mining methods (decision tree induction, neural networks, and composite classifiers) have been conducted. The composite classifier architecture has been shown to yield higher accuracy than the accuracy of each individual classifier on its own. The paper suggests that data mining methodologies may be particularly useful when data is scarce, and the various physical and chemical parameters that affect the process exhibit highly complex interactions. Another implication is that on-line monitoring of the cleaning process using data mining may be highly effective.
Spectrophotometric Determination of Vandium(V) with Benzohydroxamic Acid and 1-Hexanol (1955)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSpectrophotometric Determination of Vandium(V) with Benzohydroxamic Acid and 1-HexanolW. M. Wise and W. W. BrandtCite this: Anal. Chem. 1955, 27, 9, 1392–1395Publication Date (Print):September 1, 1955Publication History Published online1 May 2002Published inissue 1 September 1955https://pubs.acs.org/doi/10.1021/ac60105a008https://doi.org/10.1021/ac60105a008research-articleACS PublicationsRequest reuse permissionsArticle Views73Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Water-Weakening Effects on the Mechanical Behavior of Different Rock Types: Phenomena and Mechanisms (2019)

The presence of water strongly affects rock properties and would be related to a series of geological disasters. To understand water saturation effects on the mechanical behavior of different rock types and interpret the underlying mechanisms of differences in water sensitivity, three kinds of rocks, namely sandstone, granite and marble, were selected for tests. Uniaxial compression experiments were conducted on specimens under oven-dried and water-saturated conditions. Acoustic emission (AE) techniques were also applied to monitor and record AE signals during tests. Experimental results reveal that water weakens the mechanical parameters of the three tested rocks, such as uniaxial compressive strength (UCS), elastic modulus and critical strain. The sandstone undergoes the greatest weakening with the addition of pore water, the mechanical properties of the granite exhibit relatively minor reductions, while the marble is the least affected by water saturation. The water-weakening degree of rock properties depends on the porosity as well as the mineralogy, especially the proportion of quartz and swelling clays. Moreover, after water saturation, the failure pattern of the sandstone and the granite tends to transform into the shear-dominant mode from the tensile one in dry state, probably due to frictional reduction. However, the water presence does not change the failure mode of the marble.