gebhart/patrepeval huggingface dataset:
Cross-Protection in Mice After Immunization with H2N2, H3N2, and Heq2Neq2 Influenza Virus Strains (1978)

Mice were vaccinated with the influenza viruses A/Japan/57 (H2N2), A/Hong Kong/68 (H3N2), and A/Equi/Miami/63 (Heq2Neq2) and the hemagglutinin and neuraminidase recombinants derived from these viruses. After infection with the parent viruses, protection was compared with serological findings. It was found that influenza vaccine protects not only against infection with a strain identical or closely related to the vaccine strain, but against heterologous strains as well. Vaccination with Hong Kong/68 and its neuraminidase recombinant resulted in a heterologous neuraminidase inhibition titer against Japan/57 and in a protection against infection with Japan/57. By contrast, after vaccination with Japan/57 and its neuraminidase recombinant, no relevant heterologous neuraminidase inhibition titer against Hong Kong/68 was observed, whereas a protection against infection with Hong Kong/68 did exist. A cross-protection between Hong Kong/68 and Miami/63, but no relationship in the hemagglutination or neuraminidase inhibition tests, was established in the preinfection sera. A one-way antigenic relationship between these viruses was confirmed by the rise of hemagglutinin or neuraminidase antibodies against Hong Kong/68 in the postinfection sera. No cross-protection or serological relationship existed between Miami/63 and Japan/57. Besides the hemagglutinin and neuraminidase, a third factor, the "mouse-protecting antigen," was considered to contribute to the protection obtained. According to the protection observed, the mouse-protecting antigen of Hong Kong/68 virus is related to that of Japan/57 as well as Miami/63 virus. The mouse-protecting antigens of both Japan/57 and Miami/63 are related to that of Hong Kong/68.
Involvement of Hyaluronan in Regulation of Fibroblast Phenotype (2007)

This study aimed to understand the role of the matrix polysaccharide, hyaluronan (HA), in influencing the scarring process by assessing its impact on regulating fibroblast behavior. Donor-matched human oral and dermal fibroblasts were used as models of nonscarring and scarring fibroblast phenotypes, respectively. Phenotypic differences in these two fibroblast populations were assessed and related to differences in HA synthesis and assembly. The two fibroblast populations showed intrinsic differences in their response to the profibrotic cytokine, transforming growth factor-beta1 (TGFbeta1), in that oral fibroblasts were resistant to TGFbeta1-driven myofibroblastic differentiation. In dermal fibroblasts, differentiation was associated with an induction of HA synthase (HAS1 and HAS2) transcription and assembly of pericellular HA coats. In comparison, resistance to differentiation in oral fibroblasts was associated with failure of induction of HAS1 and HAS2 transcription and failure of pericellular coat assembly. Furthermore, inhibition of HA synthesis in dermal fibroblasts significantly attenuated TGFbeta1-mediated differentiation. Interleukin-1beta stimulation resulted in induction of HAS1 and HAS2 transcription but did not induce phenotypic differentiation or induce HA coat assembly. In addition, neither overexpression nor down-regulation of HAS1 (the isoform uniquely deficient in nonscarring oral fibroblasts) influenced phenotypic differentiation. In conclusion, inhibiting HA synthesis modulates TGFbeta1-dependent responses in these cells preventing fibroblast to myofibroblast differentiation. Moreover, HA pericellular coat assembly, rather than HAS isoform expression, appears to be associated with phenotypic differentiation.
An Ultra-Bright Pulsed Electron Beam with Low Longitudinal Emittance (2006)

Most existing electron sources extract electrons from conductors. Since the actual temperature inside the conductor is much less than the Fermi temperature of the conduction electrons, the electron degeneracy δ <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">f</inf> is close to 1, the maximum allowed by the Pauli exclusion principle. However, during extraction several factors conspire together to reduce δ <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">f</inf> many orders of magnitude, limiting the achieved values to ≈ 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">−5</sup> . A new concept is described for building a novel electron source designed to produce a pulsed beam with δ <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">f</inf> ≈ 2 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">−3</sup> and longitudinal emittance four orders of magnitude smaller than currently achieved values. This high brightness, low longitudinal emittance regime enables a wide range of novel applications that utilize angstrom-scale spatial resolution and eV-scale energy resolution. The current state of a proof-of-principle experiment conducted at LBNL is also described.
Alloy Design for Heat Treatment of High Pressure Diecastings (2009)

Recently, heat treatment technologies have been developed by the CSIRO Light Metals Flagship in Australia that allow the yield stress in conventional aluminium HPDC’s to be more than doubled without encountering problems with blistering or dimensional instability. These procedures involve a severely truncated solution treatment step conducted at lower than normal temperatures followed by quenching and artificial ageing. Typically, heat treated HPDC’s may display increases to the yield stress of around 80 to 100%, but a range of other properties may also be improved such as fatigue resistance, thermal conductivity and fracture resistance for some tempers. However, the HPDC alloys currently used worldwide have not been developed specifically for heat treatment or the optimization of specific properties. In particular, recent work in Al-Si-Cu HPDC alloys has identified ranges of alloys specifically for achieving yield strengths exceeding 400 MPa, or for high strength combined with elevated ductility levels. The role of alloying elements, composition limits and effects on microstructure development are discussed.
Timeline on the application of intercalation materials in Capacitive Deionization (2019)

Capacitive deionization is a water desalination technology in which ions are stored in electrodes in an electrochemical cell construction, connected to an external circuit, to remove ions present in water from various sources. Conventionally, carbon has been the choice of material for the electrodes due to its low cost, low contact resistance and high specific surface area, electronic conductivity, and ion mobility within pores. The ions in the water are stored at the pore walls of these electrodes in an electrical double layer. However, alternative electrode materials, with a different mechanism for ion and charge storage, referred to as ion intercalation, have been fabricated and studied as well. The salt adsorption performance exhibited by these materials is in most cases higher than that of carbon electrodes. This work traces the evolution of the study of redox activity in these intercalation materials and provides a chronological description of major developments in the field of Capacitive Deionization (CDI) with intercalation electrodes. In addition, some insights into the cell architecture and operation parameters are provided and we present our outlook of future developments in the field of intercalation materials for CDI.
Sequential Monte Carlo implementation and state extraction of the group probability hypothesis density filter for partly unresolvable group targets-tracking problem (2010)

This study proposes a sequential Monte Carlo (SMC) implementation to the Mahler's group probability hypothesis density filter (PHDF) for partly unresolvable group targets tracking problem. A potential limitation of the group PHDF is that it cannot be used to determine the number of groups. Therefore we have to jointly extract the group number and states from the proposed group SMC-PHDF at each time step. We propose to fit the resampled particles of the group SMC-PHDF by application of Gaussian mixture models with unknown component number. In the mixture, the number and parameters of the components correspond to the number and states of the groups over the observation region. The Markov chain Monte Carlo (MCMC) algorithm is proposed to estimate the component parameters of the mixture. The estimate of component number of the mixture can be derived by a component management strategy. In simulation, the proposed group SMC-PHDF with the expectation maximum (EM) and MCMC extractions are, respectively, used to detect and track the groups. Hundred Monte Carlo simulation results show that the latter outperforms the former a lot in estimating the group number and states, although the computational requirement of the MCMC extraction is more expensive than the EM extraction.
Blastomeres and cells with mesendodermal fates of carp embryos express cth1, a member of the TIS11 family of primary response genes (1998)

The carp cth1 gene, related to the mammalian TIS11 family of primary response genes, encodes a novel fish protein with two putative CCCH zinc fingers. This report describes the RNA expression of this gene during cleavage, blastula and gastrula stages of carp embryos. Cth1 mRNA is present in all cleavage stage blastomeres as a maternal message. After the late blastula stage, the maternal expression decreases, revealing a spot of higher expression at the margin of the blastoderm of the dome stage embryo. Further decrease of the maternal message reveals a ring of cth1 expressing cells at the blastoderm margin from the stage of 40% epiboly onwards. By alpha-amanitin treatment we established that this local cth1 expression is of zygotic origin. At the onset of gastrulation the cells of the cth1 ring involute, starting with those in the shield region, and at approximately 60% epiboly the ring is fully involuted and occupies the hypoblast layer. All cth1 transcripts have disappeared at completion of epiboly. We discuss a possible role for the putative cth1 protein during cleavage and gastrulation.
Structure-Based Design and Pharmacokinetic Optimization of Covalent Allosteric Inhibitors of the Mutant GTPase KRAS<sup>G12C</sup> (2020)

Attempts to directly drug the important oncogene KRAS have met with limited success despite numerous efforts across industry and academia. The KRAS<sup>G12C</sup> mutant represents an "Achilles heel" and has recently yielded to covalent targeting with small molecules that bind the mutant cysteine and create an allosteric pocket on GDP-bound RAS, locking it in an inactive state. A weak inhibitor at this site was optimized through conformational locking of a piperazine-quinazoline motif and linker modification. Subsequent introduction of a key methyl group to the piperazine resulted in enhancements in potency, permeability, clearance, and reactivity, leading to identification of a potent KRAS<sup>G12C</sup> inhibitor with high selectivity and excellent cross-species pharmacokinetic parameters and in vivo efficacy.
Time course of inhibition of hypertension by antisense oligonucleotides targeted to AT1 angiotensin receptor mRNA in spontaneously hypertensive rats*1 (1997)

Antisense oligodeoxynucleotides (AS-ODN) can be designed to provide inhibition of a specific protein. Since angiotensin receptors are involved in blood pressure regulation we constructed AS-ODN to angiotensin II type-1 receptor (AT1) mRNA. When given centrally, the AS-ODN reduces blood pressure in spontaneously hypertensive rats (SHR) 24 h after injection. To study the time course of a single AS-ODN injection on blood pressure and heart rate, groups of SHR were injected intracerebroventricularly (icv) with either single dose of AS-ODN or scrambled (SC) ODN and blood pressure was recorded through implanted catheters daily for up to 9 days. Blood pressure decreased significantly in the AS-ODN treated rats compared to the SC-ODN rats for up to 7 days. The maximum decrease (38 mm Hg) occurred at 3 days. There appeared to be no toxic reaction or side effects and the blood pressure level had recovered by days 8 and 9. Heart rate was not altered by AS-ODN treatment. To test that the ODN was entering the brain tissue, fluorescein-isothiocyanate labelled (FITC) ODN was injected in Sprague-Dawley rats and the fluorescence detected 1 h later by confocal microscopy. Within 1 h there was rapid uptake into cells close to the site of injection and into brain parenchyma around the third and lateral ventricles. To test that the AS-ODN had reduced AT1 receptors, binding studies were carried out on membranes from hypothalamic tissue. There was a modest (∼20%) but significant (P < .05) decrease in the AT1 receptor binding after 25 μm or 50 μm AS-ODN. AT2 receptors were not altered by the AS-ODN, indicating its specificity for the AT1 receptor. The small decrease in receptor binding, relative to its large effect on blood pressure, is discussed in terms of the AT1 receptor life cycle. The mechanism for the long action of a single-AS-ODN injection is hypothesized as resulting from the persistence of AS-ODN in the nucleus, preventing transport of the mRNA into the cytoplasm. Am J Hypertens 1997;10:56S-62S © 1997 American Journal of Hypertension, Ltd.
An Integrated Approach to Incorporating Research Findings into Practice (1993)

Associate professor at the University of Colorado School of Nursing, and vice president for Nursing Research and Education, The Children's Hospital, Denver. She is responsible for the development and implementation of the hospital's research program and oversees the nursing education department. certified pediatric nurse practitioner, she is currently conducting a study funded by a grant from the National Center for Nursing Reseach exploring etiology and management of infant colic
Surface MS: Probing Real-World Samples (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSurface MS: Probing Real-World SamplesAlfred Benninghoven, Birgit Hagenhoff, and Ewald NiehuisCite this: Anal. Chem. 1993, 65, 14, 630A–640APublication Date (Print):July 15, 1993Publication History Published online31 May 2012Published inissue 15 July 1993https://pubs.acs.org/doi/10.1021/ac00062a717https://doi.org/10.1021/ac00062a717research-articleACS PublicationsRequest reuse permissionsArticle Views79Altmetric-Citations117LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Social drive (2013)

This paper presents Social Drive, a novel crowdsourcing-based vehicular social networking (VSN) system for green transportation. Social Drive integrates the standard vehicular On-Board Diagnostics (OBD) module, leverages the advantages of cloud computing and popular social networks, and incorporates a novel rating mechanism about the fuel economy of drivers. Based on these, Social Drive provides a user-friendly mobile application on smartphones targeting drivers, which enables a seamless and economic solution that promote drivers' awareness of their driving behaviors regarding fuel economy of specific trips. Our practical experiments have demonstrated that Social Drive works efficiently with low battery consumption and low networking overhead on popular mobile devices.
Extended Follow-up of Long-Term Survivors of Childhood Acute Lymphoblastic Leukemia (2003)

Children with acute lymphoblastic leukemia who did not receive radiation therapy and who have attained 10 or more years of event-free survival can expect a normal long-term survival. Irradiation is associated with the development of second neoplasms, a slight excess in mortality, and an increased unemployment rate.
Rectal 5-aminosalicylic acid for induction of remission in ulcerative colitis (2010)

Rectal 5-ASA should be considered a first-line therapy for patients with mild to moderately active distal UC. The optimal total daily dose and dose frequency of 5-ASA remain to be determined. Future research should define differences in efficacy among patient subgroups defined by proximal disease margin and disease activity. There is a strong need for consensus standardization of outcome measurements for clinical trials in ulcerative colitis.
The synthesis of 8‐oxoberbines containing a heterocyclic D‐ring by enamide photocyclizations (1979)

Abstract The photocyclization of 2‐heteroyl‐1‐methyleneyl‐3,4‐dihydro‐6,7‐dimethoxyisoquinolines, where heteroyl = benzofuran, benzo[ b ]thiophene, coumarin and nicotinoyl, leads to the corresponding 8‐oxoberbines containing a heterocyclic D‐ring. Dehydrogenation can accompany photocyclization depending on the reaction conditions employed, or alternatively DDQ can be used to effect this dehydrogenation.
A 0.13 μm high-performance SOI logic technology with embedded DRAM for system-on-a-chip application (2002)

Reports the successful implementation of a 0.13 /spl mu/m high-performance, silicon-on-insulator (SOI) logic technology to produce a 0.13 /spl mu/m logic-based embedded DRAM (eDRAM) on substrates composed of both bulk Si and SOI or pattern SOI. eDRAM macros are constructed in bulk regions of the wafer and high-performance logic circuits lie on SOI. Pattern SOI wafers are produced by blocking out selected regions of p-type Si wafers from the separation by implantation of oxygen (SIMOX) implant using a thick (> 1 /spl mu/m) hard mask. Test results indicate that SOI eDRAM yield and retention characteristics are comparable to bulk eDRAM. Based on ring oscillator tests, the use of 0.13 /spl mu/m SOI logic devices improves switching speeds by >20% over 0.13 /spl mu/m bulk technology at 1.2 Vdd. These results pave the way for future generations of low power SOI system-on-a-chip (SOC) applications, starting at the 0.1 /spl mu/m node.
Pores in the sieve and channels in the wall: control of paracellular permeability by junctional proteins in endothelial cells. (2001)

Exchange of solutes and ions between the luminal and abluminal compartments of the circulation is critically dependent on the barrier properties of the vascular endothelium. Transport of solutes and fluids occurs along the transcellular and paracellular pathways that are mediated by intracellular vesicles and intercellular junctions, respectively. Although the ability of endothelial cells to dynamically regulate permeability has long been recognized, the precise mechanism and the signaling pathways involved have not been fully elucidated. Finally, current definition of the complex molecular composition of intercellular junctions is expected to explain the difference in permeability between diverse segments of the circulation and possibly to highlight the existence of specific junctional channels. The properties of junctional adhesion molecule-1 (JAM-1) and vascular endothelial cadherin (VE-cadherin), two transmembrane components of interendothelial junctions, are described in detail.
A yield and day length requirement evaluation of single- and multi-cut sainfoin (Onobrychis viciaefolia Scop.) (2015)

Seventeen sainfoin lines (Onobrychis viciaefolia Scop.), 'Eski' sainfoin (0. viciaefolia Soop.), 'Ladak' and 'Haymor' alfalfa (Medicago sativa L ) were evaluated for their regrowth and forage yielding ability for two years at two locations.Two weeks follpwing the first harvest, the seventeen sainfoin lines were 9-12 inches high compared to the 4-6' inch height of Eski.Eski produced 78% of its total season yield the first harvest compared to a range of 57-70% for the regrowth lines at Bozeman, Montana.Under three-cut conditions at Huntley, Montana, Eski yielded 6l% the first harvest and the regrowth lines ranged from 43-57%= At Huntley, the second harvest year all regrowth lines produced a greater total season yield than the single-cut type Eski.The two alfalfa varieties also, yielded more than Eski at Huntleyc The regrowth sainfoin lines were similar to Eski in seasonal yield at Bozeman the second harvest year0 With one exception, all sainfoin entries yielded more than Ladak and Haymor alfalfa= The day length requirement for flowering of five sainfoin clones was studied= Artificial day lengths of 13 1/2 and 16 1/2 hrs under 65-45 F day-night temperatures were used.The effect of the growth chamber day length pretreatment was also evaluated when plants were transplanted to the field= The studies did not allow separation of the growth types depending on day lengths.The day length requirements for optimum flowering were not the same for all five clones.
DECENT: A decentralized architecture for enforcing privacy in online social networks (2012)

A multitude of privacy breaches, both accidental and malicious, have prompted users to distrust centralized providers of online social networks (OSNs) and investigate decentralized solutions. We examine the design of a fully decentralized (peer-to-peer) OSN, with a special focus on privacy and security. In particular, we wish to protect the confidentiality, integrity, and availability of user content and the privacy of user relationships. We propose DECENT, an architecture for OSNs that uses a distributed hash table to store user data, and features cryptographic protections for confidentiality and integrity, as well as support for flexible attribute policies and fast revocation. DECENT ensures that neither data nor social relationships are visible to unauthorized users and provides availability through replication and authentication of updates. We evaluate DECENT through simulation and experiments on the PlanetLab network and show that DECENT is able to replicate the main functionality of current centralized OSNs with manageable overhead.
Pressure Modulates Stereoregularities in the Polymerization of Propylene Promoted by <i>rac</i>-Octahedral Heteroallylic Complexes (1998)

This communication reports the synthesis and activity of four racemic mixtures of bis(benzamidinate) group-4 complexes, cis-[p-R‘C6H4C(NR)2]2MX2 (R‘ = CH3, R = SiMe3, M = Ti, X = Cl (1); R‘ = CH3, R = SiMe3, M = Zr, X = Cl (2); R‘ = H, R = i-pr, M = Zr, X = Cl (3); R‘ = CH3, R = SiMe3, M = Zr, X = CH3 (4)) as precatalysts for the stereoregular polymerization of propylene. These complexes catalyze the stereoregular polymerization of propylene only under pressure in CH2Cl2, producing polypropylene with very large isotacticities (mmmm % = ∼95−98), high melting points (140−154 °C).