gebhart/patrepeval huggingface dataset:
Synthesis and Cyclooxygenase-2 Inhibiting Property of 1,5-Diarylpyrazoles with Substituted Benzenesulfonamide Moiety as Pharmacophore:  Preparation of Sodium Salt for Injectable Formulation<sup>†</sup> (2003)

A series of 1,5-diarylpyrazoles having a substituted benzenesulfonamide moiety as pharmacophore was synthesized and evaluated for cyclooxygenase (COX-1/COX-2) inhibitory activities. Through SAR and molecular modeling, it was found that fluorine substitution on the benzenesulfonamide moiety along with an electron-donating group at the 4-position of the 5-aryl ring yielded selectivity as well as potency for COX-2 inhibition in vitro. Among such compounds 3-fluoro-4-[5-(4-methoxyphenyl)-3-trifluoromethyl-1H-1-pyrazolyl]-1-benzenesulfonamide 3 displayed interesting pharmacokinetic properties along with antiinflammatory activity in vivo. Among the sodium salts tested in vivo, 10, the propionyl analogue of 3, showed excellent antiinflammatory activity and therefore represents a new lead structure for the development of injectable COX-2 specific inhibitors.
High gain and high peak power in planar waveguide lasers (2002)

We report enhanced peak power and gain for pulses in the 10-100 /spl mu/sec range, with specific peak power to 240 kW m/sup -2/ of electrode area at frequencies to 4 kHz. Pulsed small signal gain is increased by a factor of 7 relative to cw/long pulse excitation.
Up‐regulation of microsomal prostaglandin E synthase 1 in osteoarthritic human cartilage: Critical roles of the ERK‐1/2 and p38 signaling pathways (2004)

This study is the first to show that mPGES-1 is stimulated in human chondrocytes by the proinflammatory cytokine IL-1beta via activation of both ERK-1/2 and p38 MAPK in an isoform-specific manner. We postulate that mPGES-1 may be a novel target for OA therapy.
Animal Model Evaluation Within Herd Linked to National Evaluations (1990)

Computer programs with modest computational requirements were developed to calculate animal model evaluations on a herd basis. Evaluations are connected to the national system through parents with national evaluations and parents assigned to unknown-parent groups. The programs can be used to compute evaluations of animals in herds not included in national evaluations or to update evaluations between semiannual national evaluations for herds that are included. Computer memory requirements are reduced dramatically from those of the national system, because only data for animals with records or progeny in the herd are in memoryat any time. Computational requirements also are reduced by processing only lactation records initiated after an adjustable date; earlier lactation records are replaced by management group deviations. For older animals, processing is reduced further by not updating the animal's evaluation. When progeny evaluations no longer are updated, the animal's evaluation no longer is required. Solutions for management group, permanent environmental, and herd-sire effects are by Gauss-8eidel iteration and for animal effects by approximate successive overrelaxation.
On finding undetectable and redundant faults in synchronous sequential circuits (2002)

We describe a time-efficient procedure for identifying undetectable and redundant faults in a synchronous sequential circuit, without using a sequential circuit test pattern generator. The proposed procedure is based on the use of a limited length iterative logic array model of the circuit, and has two phases. In the first phase, faults that will not be proved to be undetectable are identified. In the second phase, undetectable faults are identified out of the remaining faults using a combinational circuit test generator. Sequential static learning on the fault-free circuit and a subset of unreachable states are used in the proposed procedure to increase the amount of information available when considering an iterative logic array model of limited length. An undetectable fault in a synchronizable circuit that leaves the faulty circuit synchronizable is identified as a redundant fault. Experimental results presented in this work demonstrate the effectiveness of the proposed techniques in finding undetectable and redundant faults. Larger numbers of undetectable and redundant faults are found compared to earlier works.
Radio altimeter interference mitigation in wireless avionics intra-communication networks (2017)

On-board commercial passenger aircraft Wireless Sensor Networks (WSNs) are anticipated to be used for implementing machine-to-machine communication also referred to as Wireless Avionics Intra-Communications (WAIC). These systems enable safety-related wireless avionics and aim to reduce electrical wiring harness contributing by 5% of the total weight of an aircraft. The globally harmonized frequency band designated for WAIC usage is shared with aeronautical Radio Altimeters (RAs). Literature lacks consideration of the impact of on-board RAs on WAIC systems; thus, we close this gap by performing a detailed study and propose two mitigation techniques based on channel hopping. Our simulations show that harmful RA signals infer doubled to tripled delays as well as packet error rates up to 90% when WAIC systems use the frequency band without applying appropriate techniques for increasing communication robustness. With the developed mitigation techniques, we show delays can be kept at levels comparable to non-interfered performance while increasing the usable spectrum by 50% simultaneously. Our evaluations show that the presented mitigation techniques enable reliable usage of WAIC systems in commercial aircraft allowing increased spectrum usage.
Nitric Oxide in Inflammatory Bowel Disease (2003)

Nitric oxide (NO) is a pleiotropic free radical messenger molecule. There is a large body of evidence that the inducible form of the NO synthase enzyme (iNOS) that is responsible for high-output production of NO from l-arginine is up-regulated in various forms of mucosal inflammation. Consistent with this, multiple detection strategies have demonstrated that iNOS expression, enzymatic activity, and NO production are increased in human inflammatory bowel disease tissues. There is also evidence that the level of iNOS-derived NO correlates well with disease activity in ulcerative colitis, while for Crohn's disease, the results are more variable. A substantial number of animal studies have assessed the role of inducible NO production. While the majority of studies have shown improvement in experimental inflammatory bowel disease with iNOS inhibition, there are also a significant number of reports of exacerbation of disease with inhibitors. Similarly, studies using iNOS-deficient mice in colitis models have shown improvement, worsening, or no effect on disease. The authors suggest that additional studies to assess the role of the competing biochemical pathway, namely the conversion of l-arginine to polyamines via the actions of arginase and ornithine decarboxylase, may provide important new insights into understanding the regulation of mucosal inflammation and inflammatory bowel disease.
miR-1 Exacerbates Cardiac Ischemia-Reperfusion Injury in Mouse Models (2012)

Recent studies have revealed the critical role of microRNAs (miRNAs) in regulating cardiac injury. Among them, the cardiac enriched microRNA-1(miR-1) has been extensively investigated and proven to be detrimental to cardiac myocytes. However, solid in vivo evidence for the role of miR-1 in cardiac injury is still missing and the potential therapeutic advantages of systemic knockdown of miR-1 expression remained unexplored. In this study, miR-1 transgenic (miR-1 Tg) mice and locked nucleic acid modified oligonucleotide against miR-1 (LNA-antimiR-1) were used to explore the effects of miR-1 on cardiac ischemia/reperfusion injury (30 min ischemia followed by 24 h reperfusion). The cardiac miR-1 level was significantly increased in miR-1 Tg mice, and suppressed in LNA-antimiR-1 treated mice. When subjected to ischemia/reperfusion injury, miR-1 overexpression exacerbated cardiac injury, manifested by increased LDH, CK levels, caspase-3 expression, apoptosis and cardiac infarct area. On the contrary, LNA-antimiR-1 treatment significantly attenuated cardiac ischemia/reperfusion injury. The expression of PKCε and HSP60 was significantly repressed by miR-1 and enhanced by miR-1 knockdown, which may be a molecular mechanism for the role miR-1 in cardiac injury. Moreover, luciferase assay confirmed the direct regulation of miR-1 on protein kinase C epsilon (PKCε) and heat shock protein 60 (HSP60). In summary, this study demonstrated that miR-1 is a causal factor for cardiac injury and systemic LNA-antimiR-1 therapy is effective in ameliorating the problem.
Transforming growth factor-beta 1 stimulation of parathyroid hormone-related protein expression in human uterine cells in culture: mRNA levels and protein secretion (1992)

Journal Article Transforming growth factor-beta 1 stimulation of parathyroid hormone-related protein expression in human uterine cells in culture: mRNA levels and protein secretion Get access M L Casey, M L Casey 1Cecil H. and Ida Green Center for Reproductive Biology Sciences, Department of Obstetrics-Gynecology, University of Texas Southwestern Medical Center, Dallas. Search for other works by this author on: Oxford Academic Google Scholar M Mibe, M Mibe 1Cecil H. and Ida Green Center for Reproductive Biology Sciences, Department of Obstetrics-Gynecology, University of Texas Southwestern Medical Center, Dallas. Search for other works by this author on: Oxford Academic Google Scholar A Erk, A Erk 1Cecil H. and Ida Green Center for Reproductive Biology Sciences, Department of Obstetrics-Gynecology, University of Texas Southwestern Medical Center, Dallas. Search for other works by this author on: Oxford Academic Google Scholar P C MacDonald P C MacDonald 1Cecil H. and Ida Green Center for Reproductive Biology Sciences, Department of Obstetrics-Gynecology, University of Texas Southwestern Medical Center, Dallas. Search for other works by this author on: Oxford Academic Google Scholar The Journal of Clinical Endocrinology & Metabolism, Volume 74, Issue 4, 1 April 1992, Pages 950–952, https://doi.org/10.1210/jcem.74.4.1548363 Published: 01 April 1992
Investigation of the Influence of CO 2 Cryogenic Coolant Application on Tool Wear (2017)

The use of cryogenic coolants has emerged as an environmentally conscious alternative to emulsion coolant options. Cryogenic media can be delivered with a variety of methods to the cutting edge and they can be used in combination with other traditional coolant options such as Minimum Quantity Lubrication (MQL) and compressed air cooling in order to aid dissipation of heat generated in the cutting zone and maximize the lubrication of the cutting edge and thus prolong tool life. This study focuses on the investigation of tool life when milling aerospace grade titanium (Ti-6Al-4 V) under different coolant delivery options. Tool wear progression was recorded for the following coolant options: cryogenic CO 2 , emulsion flood cooling, dry machining, cryogenic CO 2 combined with air or MQL as well as MQL alone.
High-precision EMG signal decomposition using communication techniques (2000)

This paper presents a new approach to the decomposition of electromyographic (EMG) signals. EMG signals consist of a superposition of delayed finite-duration waveforms that carry the information about the firing of different muscle fiber groups. The new approach is based on a communication technical interpretation of the EMG signal. The source is modeled as a signaling system with intersymbol-interference, which encodes a well defined sparse information sequence. This point of view allows a maximum-likelihood (ML) as well as a maximum a posteriori (MAP) estimation of the underlying firing pattern to be made. The high accuracy attainable with the proposed method is illustrated both with measured and artificially generated EMG signals.
Dialkylfluorene-Oligothiophene and Dialkylfluorene-Dithienylvinylene Alternating Copolymers (2002)

Well defined dialkylfluorene/oligothiophene and di­alkylfluorene/dithienylvinylene alternating copolymers have been synthesized via the polycondensation of 2,7-dibromo-(9,9-dialkyl­fluorene) with the appropriate distannylated (oligo)thienylene component according to a Stille-type coupling reaction using tetrakis(triphenylphosphine)palladium [Pd(PPh3)4] as catalyst. The alternate incorporation of the thienylene building blocks leads to the tunability of the photoluminescent properties of the alternating copolymers. The long wavelength absorption and photoluminescence maxima of the copolymers display a subsequent bathochromic shift upon increasing the size of the (oligo)thienylene building block.
Domain adaptation for statistical machine translation with domain dictionary and monolingual corpora (2008)

Statistical machine translation systems are usually trained on large amounts of bilingual text and monolingual text. In this paper, we propose a method to perform domain adaptation for statistical machine translation, where in-domain bilingual corpora do not exist. This method first uses out-of-domain corpora to train a baseline system and then uses in-domain translation dictionaries and in-domain monolingual corpora to improve the in-domain performance. We propose an algorithm to combine these different resources in a unified framework. Experimental results indicate that our method achieves absolute improvements of 8.16 and 3.36 BLEU scores on Chinese to English translation and English to French translation respectively, as compared with the baselines using only out-of-domain corpora.
Satisfacción y depresión en personas mayores (2007)

Objetivos: Se analiza el grado de satisfaccion vital y nivel de depresion en relacion a variables personales como el genero y la edad, ademas de otros indices psicosociales como el deterioro cognitivo. Metodo: Han participado 349 personas mayores de 64 anos de ambos sexos, con un nivel educativo elemental, unos niveles de dependencia leves y unos recursos sociales basicos. Se han utilizado los siguientes cuestionarios: El Filadelfia para medir el nivel de satisfaccion vital; el GDS-Yesavage para el nivel de depresion y el Mec-Lobopara el nivel de deterioro cognitivo. Los cuestionarios se les pasaron en sus propias casas sin limite de tiempo para las respuestas. Resultados: Las puntuaciones obtenidas se sometieron a tres tipos de analisis estadisticos: el descriptivo, el correlacional y el de varianza. En cuanto a las variables personales como el genero y la edad, se encontro que los varones puntuan mas alto en satisfaccion vital que las mujeres; mientras que estas puntuan mas alto en depresion que aquellos. A mayor edad de los participantes mayor es el deterioro cognitivo. En cuanto a la relacion entre las variables psicosociales, cuando mayor es la satisfaccion vital menor es el nivel de depresion. El nivel de satisfaccion parece explicar el 40% de la depresion. Conclusiones: Aunque hemos encontrado correlaciones significativas entre las variables estudiadas, el indice que mas diferencia a los participantes es el de satisfaccion vital por lo que deberia estudiarse mas profundamente.
A Galvanically Isolated DC–DC Converter Based on Current-Reuse Hybrid-Coupled Oscillators (2016)

This brief presents a fully integrated dc-dc converter consisting of only two CMOS chips, which are a power oscillator with an integrated transformer and a full-bridge rectifier. A thick inter-metal oxide layer guarantees a galvanic isolation rating as high as 5 kV. A current-reuse hybrid-coupled oscillator is proposed, which is based on a three-winding tapped isolation transformer and improves both output power and silicon area occupation with respect to previous works. The converter is operated at 5-V power supply and is able to deliver up to 300-mW dc power at 10-V output voltage while exhibiting a power density and a power efficiency of 36 mW/mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> and 24%, respectively.
Some Characteristics of the Disk-Scraper Oil-Feed Mechanism (1980)

The disk-scraper mechanism is commonly used in self-contained journal bearings as a lubricator. Two types cf fixed clearance scrapers and a floating plow-type scraper were investigated experimentally. The effects of speed, viscosity, clearances and immersion on flow were found by systematic variation. For each type, the flow was found to increase, with speed, N, to a critical value, Nc, and then decrease, in some cases to zero at N ≃ 2.5 Nc. The dominant parameter affecting both critical speed and flow below critical speed was found to be the immersion. Viscosity and system clearances had comparatively mild effects. Of the scrapers tested, the floating-plow type was found to be superior in several respects.
A deformable template approach to detecting straight edges in radar images (1996)

This paper addresses the problem of locating two straight and parallel road edges in images that are acquired from a stationary millimeter-wave radar platform positioned near ground-level. A fast, robust, and completely data-driven Bayesian solution to this problem is developed, and it has applications in automotive vision enhancement. The method employed in this paper makes use of a deformable template model of the expected road edges, a two-parameter log-normal model of the ground-level millimeter-wave (GLEM) radar imaging process, a maximum a posteriori (MAP) formulation of the straight edge detection problem, and a Monte Carlo algorithm to maximize the posterior density. Experimental results are presented by applying the method on GLEM radar images of actual roads. The performance of the method is assessed against ground truth for a variety of road scenes.
The Weightless Intraocular Lens (1977)

<p>This paper explores the use of Column Generation (CG) techniques in constructing univariate binary decision trees for classification tasks. We propose a novel Integer Linear Programming (ILP) formulation, based on root-to-leaf paths in decision trees. The model is solved via a Column Generation based heuristic. To speed up the heuristic, we use a restricted instance data by considering a subset of decision splits, sampled from the solutions of the well-known CART algorithm. Extensive numerical experiments show that our approach is competitive with the state-of-the-art ILP-based algorithms. In particular, the proposed approach is capable of handling big data sets with tens of thousands of data rows. Moreover, for large data sets, it finds solutions competitive to CART.</p>
<i>ATM</i> sequence variants associate with susceptibility to non‐small cell lung cancer (2007)

Abstract ATM gene mutations have been implicated in many human cancers. However, the role of ATM polymorphisms in lung carcinogenesis is largely unexplored. We conducted a case‐control analysis of 556 Caucasian non‐small‐cell lung cancer (NSCLC) patients and 556 controls frequency‐matched on age, gender and smoking status. We genotyped 11 single nucleotide polymorphisms of the ATM gene and found that compared with the wild‐type allele‐containing genotypes, the homozygous variant genotypes of ATM 08 (rs227060) and ATM 10 (rs170548) were associated with elevated NSCLC risk with ORs of 1.55 (95% CI: 1.02–2.35) and 1.51 (0.99–2.31), respectively. ATM haplotypes and diplotypes were inferred using the Expectation‐Maximization algorithm. Haplotype H5 was significantly associated with reduced NSCLC risk in former smokers with an OR of 0.47 (0.25–0.96) compared with the common H1 haplotype. Compared with the H1–H2 diplotype, H2–H2 and H3–H4 diplotypes were associated with increased NSCLC risk with ORs of 1.58 (0.99–2.54) and 2.29 (1.05–5.00), respectively. We then evaluated genotype–phenotype correlation in the control group using the comet assay to determine DNA damage and DNA repair capacity. Compared with individuals with at least 1 wild‐type allele, the homozygous variant carriers of either ATM 08 or ATM 10 exhibited significantly increased DNA damage as evidenced by a higher mean value of the radiation‐induced olive tail moment ( ATM 08: 4.86 ± 2.43 vs . 3.79 ± 1.51, p = 0.04; ATM 10: 5.14 ± 2.37 vs . 3.79 ± 1.54, p = 0.01). Our study presents the first epidemiologic evidence that ATM genetic variants may affect NSCLC predisposition, and that the risk‐conferring variants might act through down‐regulating the functions of ATM in DNA repair activity upon genetic insults such as ionizing radiation. © 2007 Wiley‐Liss, Inc.
LC/MS/MS analysis of the endogenous dimethyltryptamine hallucinogens, their precursors, and major metabolites in rat pineal gland microdialysate (2013)

We report a qualitative liquid chromatography-tandem mass spectrometry (LC/MS/MS) method for the simultaneous analysis of the three known N,N-dimethyltryptamine endogenous hallucinogens, their precursors and metabolites, as well as melatonin and its metabolic precursors. The method was characterized using artificial cerebrospinal fluid (aCSF) as the matrix and was subsequently applied to the analysis of rat brain pineal gland-aCSF microdialysate. The method describes the simultaneous analysis of 23 chemically diverse compounds plus a deuterated internal standard by direct injection, requiring no dilution or extraction of the samples. The results demonstrate that this is a simple, sensitive, specific and direct approach to the qualitative analysis of these compounds in this matrix. The protocol also employs stringent MS confirmatory criteria for the detection and confirmation of the compounds examined, including exact mass measurements. The excellent limits of detection and broad scope make it a valuable research tool for examining the endogenous hallucinogen pathways in the central nervous system. We report here, for the first time, the presence of N,N-dimethyltryptamine in pineal gland microdialysate obtained from the rat.
Gram-Negative Bacterial Lysins (2020)

Antibiotics have had a profound impact on human society by enabling the eradication of otherwise deadly infections. Unfortunately, antibiotic use and overuse has led to the rapid spread of acquired antibiotic resistance, creating a major threat to public health. Novel therapeutic agents called bacteriophage endolysins (lysins) provide a solution to the worldwide epidemic of antibiotic resistance. Lysins are a class of enzymes produced by bacteriophages during the lytic cycle, which are capable of cleaving bonds in the bacterial cell wall, resulting in the death of the bacteria within seconds after contact. Through evolutionary selection of the phage progeny to be released and spread, these lysins target different critical components in the cell wall, making resistance to these molecules orders of magnitude less likely than conventional antibiotics. Such properties make lysins uniquely suitable for the treatment of multidrug resistant bacterial pathogens. Lysins, either naturally occurring or engineered, have the potential of being developed into fast-acting, narrow-spectrum, biofilm-disrupting antimicrobials that act synergistically with standard of care antibiotics. This review focuses on newly discovered classes of Gram-negative lysins with emphasis on prototypical enzymes that have been evaluated for efficacy against the major antibiotic resistant organisms causing nosocomial infections.