gebhart/patrepeval huggingface dataset:
Secreted phosphoprotein markers for neoplastic transformation of human epithelial and fibroblastic cells. (1985)

A wide variety of rodent tumor cells of both fibroblastic and epithelial origins secrete a major transformation-related phosphoprotein with a molecular weight of approximately 62,000. Tumorigenic cells, regardless of the transforming agent, secrete 10-fold or more of this 32P-labeled protein as compared with their nontumorigenic counterparts. In this study we have extended these previous findings to tumorigenic human cells of diverse origins (both sarcomas and carcinomas). Metabolic labeling of cells with [32P]orthophosphate and immunoprecipitation with antibody specifically directed against the rat transformation-dependent secreted phosphoprotein have been used to identify antigenically related human phosphoproteins (Mr 66,000-69,000). Of the 14 human cell lines examined, all 8 of the lethal tumorigenic cell populations secreted these phosphoproteins either in continuous culture or as fresh explants from nude mice while the six nonmalignant cell lines did not (tumorigenicity in all cases was assayed in nude mice). Included in our study were three tumorigenic human cell lines (two sarcomas, one carcinoma), each with a matched, nontumorigenic control. The very close correlation between secretion of these phosphoproteins and the tumor cell phenotype of both rodents and humans raises the possibility that they may be important for tumor growth in vivo.
Hydrolysis of Molybdenum(VI). Ultracentrifugation, Acidity Measurements, and Raman Spectra of Polymolybdates (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHydrolysis of Molybdenum(VI). Ultracentrifugation, Acidity Measurements, and Raman Spectra of PolymolybdatesJ. Aveston, E. W. Anacker, and James S. JohnsonCite this: Inorg. Chem. 1964, 3, 5, 735–746Publication Date (Print):May 1, 1964Publication History Published online1 May 2002Published inissue 1 May 1964https://pubs.acs.org/doi/10.1021/ic50015a030https://doi.org/10.1021/ic50015a030research-articleACS PublicationsRequest reuse permissionsArticle Views1163Altmetric-Citations168LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
An Analysis of Economic Gaps between Different Regions in Jilin Province (2003)

According to Kuznets' inverted U hypothesis, the widening economic gaps between different regions are resulted from the disequilibriums of the regional economic growth in Chinese rapid economic development. In order to narrow the economic gaps between different regions in Jilin Province and promote a balanced development of the different regions, a common market based on the information and expressways needs to be formed.
The role of the metabolic lesion in Alzheimer's disease (2002)

This paper discusses the hypothesis that the cerebrometabolic deficiency in Alzheimer's disease(AD) is the proximate cause of the clinical disability. Several sets of observations support this hypothesis. (1) Impaired brain metabolism essentially always occurs in clinically significant AD, and the degree of clinical disability is proportional to the degree of metabolic impairment. The earliest, mildest changes in brain metabolism occur even before the onset of measurable cognitive impairment or atrophy. This observation disproves the now outdated assumption that the decreased metabolism is simply a consequence of decreased mental function or of atrophy. One of the important mechanisms reducing brain metabolism in AD appears to be damage to key mitochondrial components. Another appears to relate to inappropriate responses to insulin, i.e. to diabetes of the brain. (2) Inducing impairments of brain metabolism causes changes in mentation that mimic the clinical disabilities in AD, in both humans and experimental animals. (3) Preliminary results from several units suggest that treatment directed at the impairment of brain metabolism can improve neuropsychological functions in AD patients. The hypothesis presented here in no way negates the importance of other mechanisms in AD, such as amyloid accumulation, vascular compromise, and free radical action. However, those other abnormalities including amyloidosis can occur in people whose mentation is still clinically unimpaired. In contrast, once significant decrease in the rate of brain metabolism occurs, mentation becomes defective.
On-line single-particle analysis by laser desorption mass spectrometry (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOn-line single-particle analysis by laser desorption mass spectrometryP. J. McKeown, M. V. Johnston, and D. M. MurphyCite this: Anal. Chem. 1991, 63, 18, 2069–2073Publication Date (Print):September 15, 1991Publication History Published online1 May 2002Published inissue 15 September 1991https://pubs.acs.org/doi/10.1021/ac00018a033https://doi.org/10.1021/ac00018a033research-articleACS PublicationsRequest reuse permissionsArticle Views396Altmetric-Citations125LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Semitransparent cathodes for organic light emitting devices (2000)

We optimize transparent organic light emitting devices (TOLEDs) using compound cathodes consisting of a thermally evaporated metal contact layer capped with indium–tin–oxide (ITO). The ITO is sputtered at rates of up to 1.6 Å/s using a high power radio frequency magnetron process. With a Mg:Ag contact layer, we demonstrate a TOLED with 50% transparency and an operating voltage within 0.3 V of a device with identical organic layers and a conventional Mg:Ag cathode. The operational lifetime of the TOLED is shown to be equal to that of a similar, nontransparent device. We also study the effects of using different contact metals, including Ca, Al and LiF, on the operating characteristics of the TOLEDs. With a thin Ca contact layer, undoped TOLEDs with &gt;80% peak transparency operating at (5.9±0.1) V at a brightness of &gt;100 cd/m2 are demonstrated. These devices have application to transparent, head-up displays and to full color, stacked organic light emitting devices.
The International Collaborative Group on HNPCC. (1994)

The international collaborative group on HNPCC (ICG-HNPCC) was established in 1989. The original aims of the group were: (1) to develop minimal criteria for the identification of HNPCC, to provide a basis for uniformity in collaborative studies; (2) to improve patient and physician education about HNPCC; (3) to establish international collaborative studies, and (4) to promote the establishment of national (or regional) HNPCC registries. The administrative base of the group is attached to the Netherlands Foundation for the Detection of Hereditary Tumours at Leiden. The Netherlands. An International Informational Center on HNPCC was established at Creighton University in Omaha. The Hereditary Colon Cancer Newsletter (previously the Polyposis Newsletter) serves as a medium for communication about activities of the Group. At present, the Group has about 70 members from 23 countries, and its meetings are held annually. After a period of five years, it can be concluded that the objectives of the ICG-HNPCC have been successfully accomplished. The existence of the ICG-HNPCC has contributed to an increase in awareness of HNPCC among specialists throughout the world. Due to the rapid developments in molecular genetics in HNPCC, it seems very likely that HNPCC will be the first common hereditary cancer syndrome, which can be identified by simple blood DNA tests. The value of the ICG-HNPCC will be extremely important in finding a uniform answer to the question how to utilize DNA technology for the benefit of the human race.
Investigation of Negative Valve Overlap Reforming Products Using Gas Sampling and Single-Zone Modeling (2015)

<div class="section abstract"><div class="htmlview paragraph">Negative valve overlap (NVO) is a viable control strategy that enables low-temperature gasoline combustion (LTGC) at low loads. Thermal effects of NVO fueling on main combustion are well understood, but fuel reforming chemistry during NVO has not been extensively studied.</div><div class="htmlview paragraph">The objective of this work is to analyze the impact of global equivalence ratio and available oxidizer on NVO product concentrations. Experiments were performed in a LTGC single-cylinder engine under a sweep of NVO oxygen concentration and NVO fueling rates. Gas sampling at the start and end of the NVO period was performed via a custom dump-valve apparatus with detailed sample speciation by gas chromatography. Single-zone reactor models using detailed chemistry at relevant mixing and thermodynamic conditions were used in parallel to the experiments to evaluate expected yields of partially oxidized species under representative engine time scales. Modeling efforts help identify physical mechanisms that further describe experimental findings with regards to anticipated fuel-fraction and temperature fields.</div><div class="htmlview paragraph">For the NVO fueling sweep, end-cycle CO<sub>2</sub> concentrations remained essentially flat, while intermediate species concentrations rose as fueling rates increased. The rate-of-increase was most pronounced for the C<sub>3</sub>-C<sub>4</sub> hydrocarbons whose rate-of-increase was greater than the relative increase in fueling rate. Modeling results suggest that oxygen depleted environments coupled with lower heat release temperatures result in slower reforming rates, which yielded higher C<sub>3</sub>-C<sub>4</sub> production. For the oxygen concentration sweep with fixed NVO fueling, CO and CO<sub>2</sub> products increased as the amount of oxidizer likewise increased. These increases came at the expense of intermediate hydrocarbon yields.</div></div>
FEXT Crosstalk Cancellation for High-Speed Serial Link Design (2006)

We have proposed and verified an efficient architecture for a high-speed I/O transceiver design that implements far-end crosstalk (FEXT) cancellation. In this design, TX pre-emphasis, used traditionally to reduce ISI, is combined with FEXT cancellation at the transmitter to remove crosstalk-induced jitter and interference. The architecture has been verified via simulation models based on channel measurement. A prototype implementation of a 12.8Gbps source-synchronous serial link transmitter has been developed in TSMC's 0.18mum CMOS technology. The proposed design consists of three 12.8Gbps data lines that uses a half-rate PLL clock of 6.4GHz. The chip includes a PRBS generator to simplify multi-lane testing. Simulation results show that, even with a 2times reduction in line separation, FEXT cancellation can successfully reduce jitter by 51.2 %UI and widen the eye by 14.5%. The 2.5 times 1.5 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> core consumes 630mW per lane at 12.8Gbps with a 1.8V supply
Age-dependent specification of the corticocortical connections of cerebral grafts (1995)

To investigate further the factors involved in the development of cerebral cortical circuitry, we examined the organization of corticocortical connections of heterotopic grafts of fetal cortex placed into neonatal rat cortices. Presumptive perirhinal or sensorimotor areas of the cerebral wall were removed as slabs from embryonic day 12 (E12), E13, or E14 rats and transplanted heterotopically into either rostral perirhinal or sensorimotor cortical areas of neonatal rats. Two weeks later, the afferent cortical connections of the grafts were labeled by placing DilC18(-3) (Dil) into each transplant site. Both the E12 and E13 heterotopic transplants of presumptive perirhinal cortex contain mostly precursor cells. When these grafts are placed into sensorimotor cortex, callosal connections are formed primarily with the contralateral sensorimotor (Sml) area, the normal projection of Sml cortex. In contrast, the E14 heterotopic transplants of the perirhinal cortical wall, containing many more postmitotic neurons, developed contralateral connections with both sensorimotor and rostral perirhinal cortices. Thus, when precursor cells are transplanted heterotopically, by using E12/E13 donor tissue, the grafts receive projections that are similar to those of the host cortical area. When older cortical neurons, together with precursors, are transplanted into a heterotopic cortical area, by using E14 donor tissue, their cortical connections exhibit both host and original donor phenotypes. The data are consistent with our previous analysis of thalamocortical connections of grafts (Barbe and Levitt, 1992b) and suggest the existence of a cell-cell recognition system for thalamocortical and corticocortical circuit formation, whose mechanisms of action may be linked to the timing of neurogenesis.
Rickettsioses of Central America (1971)

A search for rickettsial antibodies in human sera from Central America was performed by complement-fixation and microagglutination tests. Over 2,000 human sera from Guatemala, Honduras, El Salvador, Nicaragua, Costa Rica, and Panamá were surveyed for antibodies against Rickettsia prowazeki, Rickettsia typhi, Rickettsia rickettsi, Rickettsia canada, and Coxiella burneti. The results of the survey indicated that: Q fever was endemic in Central America; in areas of Costa Rica, Honduras, and Panamá a small percentage of the inhabitants had spotted fever group antibodies; Rickettsia akari infections may have occurred in Costa Rica; epidemic typhus has been a major cause of rickettsial disease in the highlands of Guatemala. A low incidence of murine typhus was also found in Guatemala. Antigenic relationships between R. canada and members of both typhus and spotted fever groups of rickettsia are indicated by complement-fixation and microagglutination tests. The study also showed the microagglutination test to be a valuable tool in epidemiological studies.
Sequential Data Assimilation Techniques in Oceanography (2003)

Summary We review recent developments of sequential data assimilation techniques used in oceanography to integrate spatio‐temporal observations into numerical models describing physical and ecological dynamics. Theoretical aspects from the simple case of linear dynamics to the general case of nonlinear dynamics are described from a geostatistical point‐of‐view. Current methods derived from the Kalman filter are presented from the least complex to the most general and perspectives for nonlinear estimation by sequential importance resampling filters are discussed. Furthermore an extension of the ensemble Kalman filter to transformed Gaussian variables is presented and illustrated using a simplified ecological model. The described methods are designed for predicting over geographical regions using a high spatial resolution under the practical constraint of keeping computing time sufficiently low to obtain the prediction before the fact. Therefore the paper focuses on widely used and computationally efficient methods.
An heuristic for maximally SRLG-disjoint path pairs calculation (2011)

Most network operators seek to offer reliable connections. The use of Shared Risk Link Groups allows an upper layer to select adequate protection paths. When path protection is used, routing algorithms seek to obtain SRLG-disjoint path pairs (or set of paths). When no totally SRLG-disjoint paths can be found one may try to obtain the SRLG least coupled (or maximally disjoint) path pair. An heuristic for maximally SRLG-disjoint path pairs calculation, considering a min-min formulation, designated TA-max, is proposed, which is a modification of the Trap Avoidance (TA) algorithm. Expressions are derived for estimating sufficient shared backup bandwidth (BBW) and for minimal BBW allocation and deallocation for partially SRLG-disjoint path pairs. The heuristic performance is evaluated using a virtual topology built over the NSFNET network and is compared with another heuristic (Modified-CoSE). Several network performance measures were considered, with and without backup bandwidth sharing, considering dynamic traffic. Results show TA-max is adequate for on-line routing and that it has better performance than Modified-CoSE regarding CPU time.
Pyruvate kinase M2 and prednisolone resistance in acute lymphoblastic leukemia (2009)

important to eliminate the possibility of Hb variants by sequencing the globin genes, which confirmed 6 positive cases on the registry.
Comportamiento del Comercio Exterior de Nicaragua en 1991 (2013)

Despues del primer intento fallido para correguir los desequilibrios macroeconomicos a traves de la ejecucion del Plan Mayorga o Plan de los Cien dias, la actual administracion del pais logro a partir del mes de marzo 91, con la puesta en marcha de un nuevo plan (Plan Lacayo), anclar la inflacion, ddisminuir con bastante exito el abultado deficit fiscal y mantener, respaldado con recursos externos, la paridad cambiaria.
Firing Behaviour of Enamels (1949)

The firing behaviour of enamels was observed under a microscope. Enamelling iron gives out much more gas than titanium steel, stainless steel or copper. The bubbles retained in the enamel in enamelling iron at the end of the firing are fewer. Enamelling iron gives out gases hours after the introduction of the plate in the furnace. Enamelling iron tends to copperhead, while the other metals investigated show a. smooth surface after firing. The size of the bubbles increases and the number decreases as the firing proceeds.
Cross-talk between α4β1/α5β1 and c-Kit results in opposing effect on growth and survival of hematopoietic cells via the activation of focal adhesion kinase, mitogen-activated protein kinase, and Akt signaling pathways (2001)

Erythroid progenitor cells (EPCs) are deficient in mice lacking either the ligand stem cell factor (SCF), its receptor c-Kit, or beta(1)-integrins. In nonhematopoietic cells, integrins and receptor tyrosine kinases can collaborate to modulate cellular functions, providing evidence for cross-talk between signals emerging from these cell surface molecules. Using specific recombinant fibronectin peptides that contain the binding site for the integrin alpha(4)beta(1) (FN-H296) or alpha(5)beta(1) (FN-CH271) or both alpha(4)beta(1) and alpha(5)beta(1) (FN-CH296), this study investigated the effect of adhesion alone, or in combination with activation of c-Kit, on functional and biochemical outcomes in an EPC line, G1E-ER2, and primary EPCs. G1E-ER2 cells and primary EPCs cultured on FN-CH271 in the presence of c-Kit activation led to a significant increase in proliferation in comparison with cells grown on FN-H296 or FN-CH296. G1E-ER2 cells cultured on FN-H296 or FN-CH296 resulted in significant cell death in comparison to cells grown on FN-CH271. Activation of c-Kit enhanced the survival of G1E-ER2 cells grown on FN-H296 or FN-CH296; however, the rescue was only partial. The reduced survival of G1E-ER2 cells on FN-H296 correlated with reduced activation of Akt and expression of Bcl-2 and Bcl-x(L), whereas increase in proliferation on FN-CH271 correlated with significantly enhanced and sustained activation of focal adhesion kinase (FAK) and extracellular-regulated kinase (ERK) pathways. These data demonstrate that adhesion-induced signals emanating from ligation of alpha(4)beta(1) and alpha(5)beta(1) result in distinct biologic outcomes, including death via alpha(4)beta(1) and survival/proliferation via alpha(5)beta(1). (Blood. 2001;97:1975-1981)
Inhibition of PCR by Agar from Bacteriological Transport Media (1998)

We observed inhibition of PCR in throat swabs submitted in routine bacteriological transport media. Experimental studies showed that agar, which was extracted with DNA by DNAzol (Gibco BRL, Gaithersburg, Md.), was the inhibitory agent. No inhibitory effect was observed with a transport medium which did not contain agar.
Interleukin-6 and its surrogate C-reactive protein are useful serum markers for monitoring metastasized malignant melanoma. (2000)

Malignant melanoma cells are known to secrete interleukin-6, and elevated interleukin-6 serum levels were reported to correlate with shorter median survival rates. We, therefore, investigated serum values of interleukin-6 and its surrogate C-reactive protein for the ability to discriminate progressive from non-progressive metastatic melanoma disease. Just prior to re-staging examinations, interleukin-6, C-reactive protein and the conventional parameter lactate dehydrogenase were determined in 74 patients with stage IV malignant melanoma according to the criteria of the American Joint Committee on Cancer. We found all tested serum parameters to be significantly elevated in progressive disease. Calculating sensitivities and specificities by logistic regression analysis, the highest sensitivities, according to the established thresholds, were found for interleukin-6 and C-reactive protein with 86% and 76%, respectively. Lactate dehydrogenase had the highest specificity with 94%. Calculating Somers' D rank correlation and the area under the "Receiver Operating Characteristic" curve, all three parameters showed high ability to driscriminate progressive from non-progressive disease. By multiple logistic regression, lactate dehydrogenase was identified to be the most statistically significant marker for progressive disease. We conclude that, comparable to lactate dehydrogenase, interleukin-6 and its surrogate C-reactive protein are useful serum markers for monitoring metastatic malignant melanoma.