gebhart/patrepeval huggingface dataset:
Prolonged antigen survival and cytosolic export in cross-presenting human γδ T cells (2010)

Human blood Vgamma9Vdelta2 T cells respond to signals from microbes and tumors and subsequently differentiate into professional antigen-presenting cells (gammadelta T-APCs) for induction of CD4(+) and CD8(+) T cell responses. gammadelta T-APCs readily take up and degrade exogenous soluble protein for peptide loading on MHC I, in a process termed antigen cross-presentation. The mechanisms underlying antigen cross-presentation are ill-defined, most notably in human dendritic cells (DCs), and no study has addressed this process in gammadelta T-APCs. Here we show that intracellular protein degradation and endosomal acidification were significantly delayed in gammadelta T-APCs compared with human monocyte-derived DCs (moDCs). Such conditions are known to favor antigen cross-presentation. In both gammadelta T-APCs and moDCs, internalized antigen was transported across insulin-regulated aminopeptidase (IRAP)-positive early and late endosomes; however, and in contrast to various human DC subsets, gammadelta T-APCs efficiently translocated soluble antigen into the cytosol for processing via the cytosolic proteasome-dependent cross-presentation pathway. Of note, gammadelta T-APCs cross-presented influenza antigen derived from virus-infected cells and from free virus particles. The robust cross-presentation capability appears to be a hallmark of gammadelta T-APCs and underscores their potential application in cellular immunotherapy.
Magneto-optic magnetic field sensors based on uniaxial iron garnet films in optical waveguide geometry (1993)

Iron garnet films which exhibit perpendicular uniaxial magnetic anisotropy are promising materials for magnetooptic magnetic field sensing. In an optical waveguide geometry, these materials exhibit large values of saturation Faraday rotation which in turn produce high sensitivity. The domain structure of these films favors magnetization rotation as the primary magnetization process. This process is significantly faster than domain wall motion, which is the primary magnetization process in bulk iron garnet crystals. Data which confirm the high sensitivity and wideband frequency response of these materials are presented. One film exhibits a virtually flat frequency response from DC to at least 1 GHz. Potential problems with waveguide sensors, such as birefringence and optical coupling efficiency appear to be soluble.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Novel Insights into the Cellular Mechanisms of the Anti-inflammatory Effects of NF-κB Essential Modulator Binding Domain Peptides (2010)

The classical nuclear factor kappaB (NF-kappaB) signaling pathway is under the control of the IkappaB kinase (IKK) complex, which consists of IKK-1, IKK-2, and NF-kappaB essential modulator (NEMO). This complex is responsible for the regulation of cell proliferation, survival, and differentiation. Dysregulation of this pathway is associated with several human diseases, and as such, its inhibition offers an exciting opportunity for therapeutic intervention. NEMO binding domain (NBD) peptides inhibit the binding of recombinant NEMO to IKK-2 in vitro. However, direct evidence of disruption of this binding by NBD peptides in biological systems has not been provided. Using a cell system, we expanded on previous observations to show that NBD peptides inhibit inflammation-induced but not basal cytokine production. We report that these peptides cause the release of IKK-2 from an IKK complex and disrupt NEMO-IKK-2 interactions in cells. We demonstrate that by interfering with NEMO-IKK-2 interactions, NBD peptides inhibit IKK-2 phosphorylation, without affecting signaling intermediates upstream of the IKK complex of the NF-kappaB pathway. Furthermore, in a cell-free system of IKK complex activation by TRAF6 (TNF receptor-associated factor 6), we show that these peptides inhibit the ability of this complex to phosphorylate downstream substrates, such as p65 and inhibitor of kappaB alpha (IkappaB alpha). Thus, consistent with the notion that NEMO regulates IKK-2 catalytic activity by serving as a scaffold, appropriately positioning IKK-2 for activation by upstream kinase(s), our findings provide novel insights into the molecular mechanisms by which NBD peptides exert their anti-inflammatory effects in cells.
Identification of <i>Clavibacter michiganensis</i> subsp. <i>sepedonicus</i> using the polymerase chain reaction (1994)

From the sequence of a subcloned DNA fragment of a highly conserved plasmid of Clavibacter michiganensis subsp. sepedonicus a pair of oligonucleotides were devised for use as polymerase chain reaction primers. The primer sequences do not show significant homology with any other sequence deposited in public databases. Polymerase chain reactions carried out using this primer pair and untreated cells of all strains of C. michiganesis sepedonicus tested resulted in the amplification of a DNA fragment of about 670 base pairs. No amplification was observed when bacteria belonging to other species were submitted to polymerase chain reaction under the same conditions. The detection limit of the assay was 4 x 10(3) bacteria.
Generalized low-error area-efficient fixed-width multipliers (2005)

In this paper, we extend our previous methodology for designing a family of low-error area-efficient fixed-width two's-complement multipliers that receive two n-bit numbers and produce an n-bit product. The generalized methodology involving four steps results in several better error-compensation biases. These better error-compensation biases can be easily mapped to low-error area-efficient fixed-width multipliers suitable for very large-scale integration implementation and digital signal processing application. Via the proposed Type 1 8 /spl times/ 8 fixed-width multiplier, the reduction of the average error can be improved by 88% compared with the direct-truncated (D-Truncated) multiplier. It is also shown that the same proposed multiplier leads to 32.75% reduction in area compared with the standard multiplier.
Phase inversion deconvolution for surface consistent processing and multiple attenuation (1999)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1999Phase inversion deconvolution for surface consistent processing and multiple attenuationAuthors: Eugene LichmanEugene Lichman11634 Manor Park Dr., Houston, TX 77077https://doi.org/10.1190/1.1820748 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InReddit Permalink: https://doi.org/10.1190/1.1820748FiguresReferencesRelatedDetailsCited byExtended Kalman Filter deconvolution for extracting accurate seismic reflectivity25 January 2022 | Boletín de Geología, Vol. 44, No. 1The use of wavelet energy absorption to estimate hydrocarbon saturation in the north Lissie field of Wharton County, TXJared Angelo1 September 2016 SEG Technical Program Expanded Abstracts 1999 ISSN (print):1052-3812 ISSN (online):1949-4645 Copyright: 1999 Pages: 2061 publication data© 1999 Copyright © 1999 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 04 Jan 2005 CITATION INFORMATION Eugene Lichman, (1999), "Phase inversion deconvolution for surface consistent processing and multiple attenuation," SEG Technical Program Expanded Abstracts : 1299-1302. https://doi.org/10.1190/1.1820748 Plain-Language Summary PDF DownloadLoading ...
UV Irradiation Effects on Chemical Vapor Deposition of SiO<sub>2</sub> (1985)

Silica (SiO 2 ) films have been deposited from a SiH 4 +O 2 +Ar system under 1849 Å irradiation by a low pressure Hg lamp without using Hg photosensitization. The oxygen partial pressure ( P O 2 ) dependence of the deposition rate has been measured in order to investigate the effects of 1849 Å irradiation. In a low P O 2 region, it is found that the increase-maximum-decrease profile due to surface reaction in thermal CVD is modified under 1849 Å irradiation. The modification of the curve profile caused by 1849 Å irradiation is due to photodesorption of adsorbed oxygen molecules from the surface. In a high P O 2 region, SiO 2 deposition is observed under 1849 Å irradiation, while SiO 2 is not deposited in thermal CVD. In this region the gas phase reaction is predominant.
Identification of haptoglobin as an alternative ligand for CD11b/CD18 (1996)

Haptoglobin is an acute phase protein with presumed anti-inflammatory activities. We report that purified fluorescein-labeled haptoglobin 1-1 binds to THP1 and U937 promonocytic cell lines, to monocytes, to granulocytes, and to a subset of CD8+ T cells and to NK cells. Studies with radioiodinated haptoglobin on THP1 cells were consistent with specific binding to one class of receptors with a density of 1.7 x 10(5) binding sites per cell and a low affinity of 6.5 x 10(-6) Kd. Binding was increased by Ca2+ and by Ca2+ and ADP. Binding to THP1 and U937 cells could be inhibited by preincubation with nonfluoresceinated haptoglobin and by fibrinogen, but not by albumin, transferrin, or alpha1-acid glycoprotein. Fibrinogen binds to the CD11b/CD18 integrin. We therefore examined whether haptoglobin has the same receptor. The anti-CD11b mAb44 indeed inhibited the binding of fluoresceinated haptoglobin to THP1 and U937 cell lines, and haptoglobin inhibited the binding of the anti-CD11b mAb anti-Leu15 and mAb44 to both cell lines. An anti-CD18 mAb partly inhibited the binding of fluoresceinated haptoglobin to THP1 and U937, indicating that the beta-chain of MAC-1 is also involved in haptoglobin binding. There was no interference between the binding of anti-CD4, anti-CD11a, or anti-CD11c mAb and haptoglobin binding to THP1 cells. Binding of haptoglobin to purified CD11b/CD18 indicates that it binds directly to the receptor. Haptoglobin is an alternative low affinity ligand for the CD11b/CD18 integrin, suggesting that this acute phase protein might regulate MAC-1-dependent cell function in vivo.
Machine Learning Meta-analysis of Large Metagenomic Datasets: Tools and Biological Insights (2016)

Shotgun metagenomic analysis of the human associated microbiome provides a rich set of microbial features for prediction and biomarker discovery in the context of human diseases and health conditions. However, the use of such high-resolution microbial features presents new challenges, and validated computational tools for learning tasks are lacking. Moreover, classification rules have scarcely been validated in independent studies, posing questions about the generality and generalization of disease-predictive models across cohorts. In this paper, we comprehensively assess approaches to metagenomics-based prediction tasks and for quantitative assessment of the strength of potential microbiome-phenotype associations. We develop a computational framework for prediction tasks using quantitative microbiome profiles, including species-level relative abundances and presence of strain-specific markers. A comprehensive meta-analysis, with particular emphasis on generalization across cohorts, was performed in a collection of 2424 publicly available metagenomic samples from eight large-scale studies. Cross-validation revealed good disease-prediction capabilities, which were in general improved by feature selection and use of strain-specific markers instead of species-level taxonomic abundance. In cross-study analysis, models transferred between studies were in some cases less accurate than models tested by within-study cross-validation. Interestingly, the addition of healthy (control) samples from other studies to training sets improved disease prediction capabilities. Some microbial species (most notably Streptococcus anginosus) seem to characterize general dysbiotic states of the microbiome rather than connections with a specific disease. Our results in modelling features of the "healthy" microbiome can be considered a first step toward defining general microbial dysbiosis. The software framework, microbiome profiles, and metadata for thousands of samples are publicly available at http://segatalab.cibio.unitn.it/tools/metaml.
Crypt cell development in newborn rat small intestine. (1985)

Three monoclonal antibodies were prepared against luminal membranes from small intestinal cells of 3-d-old rats (YBB 1/27, YBB 3/10) and crypt cell membranes from adult rats (CC 4/80). The antibodies were shown to define specific stages of development of the intestinal crypt cells. The YBB 1/27 antigen was first detected at the luminal membrane of the epithelial cells in fetal intestine at day 20 of gestation; it was confined to the crypt cells and lower villus cells between 1 and 20-22 d after birth, and could not be detected in any region of the intestine in older animals. The YBB 3/10 antigen, identified as a set of high Mr proteins, was localized over the entire surface membrane of fetal intestinal cells and of crypt and villus cells after birth; after weaning (20-22 d after birth) it gradually disappeared from the villus cells and became confined to the region of the crypts. The CC 4/80 antigen, identified as a protein (or a set of related proteins) of molecular mass 28-34 kD, was shown to appear in the crypt cells 10-14 d after birth. Its distribution changed after weaning, when it disappeared from the crypts, and was localized in the absorptive lower villus cells. This change in pattern could, in part, be prematurely elicited by cortisone injection in younger animals. These results have demonstrated the presence of specific surface membrane components on the intestinal crypt cells, and suggested that fetal antigens may be retained in these cells after birth.
Solcoderm as a Tool for the Plastic Surgeon (1984)

In 243 cases of verruca vulgaris, about 85% of the epidermal efflorescences caused by the wart virus were cured by two or more applications of Solcoderm in ambulant therapy. Of 127 cases of verruca plantaris treated, about 70% were cured after an initial course of four applications and 80% after further courses of treatment. More than 80% of recurrences responded to retreatment. A favorable effect on the pain caused by the plantaris warts was reported by 95% of the patients treated. No delayed complications were observed after the use of Solcoderm. The rate of incapacity for work after Solcoderm treatment, a total of 41 man-days, was extremely low when compared with that following cryosurgery and other surgical measures which, unlike Solcoderm therapy, often require immobilization, dressings or avoidance of soap and water.
Stochastic Filtering Methods for Predicting Agent Performance in the Smart Grid (2014)

A variety of multiagent systems methods has been proposed for forming cooperatives of interconnected agents representing electricity producers or consumers in the Smart Grid. One major problem that arises in this domain is assessing participating agents uncertainty, and correctly predicting their future behaviour. In this paper, we adopt two stochastic filtering techniques &mdash;the Unscented Kalman Filter equipped with Gaussian Processes, and the Histogram Filter&mdash; and use these to effectively monitor the trustworthiness of agent statements regarding their final actions. The methods are incorporated within a directly applicable scheme for providing electricity demand management services. Simulation results confirm that these techniques provide tangible benefits regarding enhanced consumption reduction performance, and increased financial gains.
Regulation of alternative pre-mRNA splicing by a novel repeated hexanucleotide element. (1994)

The alternatively spliced exon EIIIB is regulated in a cell type-specific manner in the rat fibronectin gene. Splicing of EIIIB into fibronectin mRNA is dependent on sequences in the intron immediately downstream of EIIIB. We show that a short, highly repeated TGCATG motif in this intron is important for cell type-specific recognition of EIIIB as an exon. This motif enhances usage of the EIIIB 5' splice site; furthermore, this repeated TGCATG sequence can activate an alternatively spliced exon in the unrelated rat preprotachykinin pre-mRNA. Interestingly, this sequence can also be found within cis-acting elements identified previously in other alternatively spliced genes. This short repeated TGCATG motif is therefore a cell type-specific element that, in addition to controlling fibronectin alternative splicing, may participate in the regulation of other alternative RNA processing events.
Exopolysaccharide (EPS) biosynthesis by Lactobacillus sakei 0-1: production kinetics, enzyme activities and EPS yields (2001)

The proposed results contribute to a better understanding of the physiological factors influencing EPS production and the key enzymes involved in EPS biosynthesis by Lact. sakei.
Competence Acquisition in an Autonomous Mobile Robot using Hardware Neural Techniques (1995)

In this paper we examine the practical use of hardware neural networks in an autonomous mobile robot. We have developed a hardware neural system based around a custom VLSI chip, EP-SILON III, designed specifically for embedded hardware neural applications. We present here a demonstration application of an autonomous mobile robot that highlights the flexibility of this sys-tem. This robot gains basic mobility competence in very few train-ing epochs using an &quot;instinct-rule &quot; training methodology. 1
CMOS-compatible traction stress sensor for use in high-resolution tactile imaging (1996)

A microstructure capable of resolving the three independent components of a point traction stress has been developed. The sensor exhibits an independent, linear response to each of the three components of an applied traction stress with measurement sensitivities of 51 mV kPa−1 in the normal stress mode and 12 mV kPa−1 in the two shear stress modes. The sensor is realized using a fabrication process that is fully CMOS compatible to allow for the future integration of local processing and control circuitry. High spatial resolution robotic tactile sensing should be possible with the sensor structure, since each element is less than 300 μm × 300 μm in size. A description of the sensor structure, the required signal processing and mechanical characterization data is presented.
Exon 3‐deleted genotype of growth hormone receptor (<i>GHR</i>d3) positively influences IGF‐1 increase at generation test in children with idiopathic short stature (2007)

This study demonstrates that ISS children carrying the GHRd3 allele, as a group, present a slightly higher GH sensitivity regarding short-term IGF-1 generation during hGH stimulus than children homozygous for GHRfl allele.
Antifungal properties of α,ω-alkanedicarboxylic acids and their dimethyl esters (1976)

<P>Abstract copyright UK Data Service and data collection copyright owner.</P><span style="font-style: italic;">Understanding Society</span> (the UK Household Longitudinal Study), which began in 2009, is conducted by the Institute for Social and Economic Research (ISER) at the University of Essex, and the survey research organisations Verian Group (formerly Kantar Public) and NatCen. It builds on and incorporates, the British Household Panel Survey (BHPS), which began in 1991.
An essential role for a mammalian SWI/SNF chromatin-remodeling complex during male meiosis (2012)

Germ cell development and gametogenesis require genome-wide transitions in epigenetic modifications and chromatin structure. These changes include covalent modifications to the DNA and histones as well as remodeling activities. Here, we explore the role of the mammalian SWI/SNF chromatin-remodeling complex during spermatogenesis using a conditional allele of the ATPase subunit, brahma-related gene 1 (Brg1, or Smarca4). Not only do BRG1 levels peak during the early stages of meiosis, genetic ablation of Brg1 in murine embryonic gonocytes results in arrest during prophase of meiosis I. Coincident with the timing of meiotic arrest, mutant spermatocytes accumulate unrepaired DNA and fail to complete synapsis. Furthermore, mutant spermatocytes show global alterations to histone modifications and chromatin structure indicative of a more heterochromatic genome. Together, these data demonstrate a requirement for BRG1 activity in spermatogenesis, and suggest a role for the mammalian SWI/SNF complex in programmed recombination and repair events that take place during meiosis.
Wireless Localization Based on RSSI Fingerprint Feature Vector (2015)

RSSI wireless signal is a reference information that is widely used in indoor positioning. However, due to the wireless multipath influence, the value of the received RSSI will have large fluctuations and cause large distance error when RSSI is fitted to distance. But experimental data showed that, being affected by the combined factors of the environment, the received RSSI feature vector which is formed by lots of RSSI values from different APs is a certain stability. Therefore, the paper proposed RSSI-based fingerprint feature vector algorithm which divides location area into grids, and mobile devices are localized through the similarity matching between the real-time RSSI feature vector and RSSI fingerprint database feature vectors. Test shows that the algorithm can achieve positioning accuracy up to 2–4 meters in a typical indoor environment.
Population norms for the MMSE in the very old (2000)

These findings provide norms for MMSE scores in subjects age 75 years and older from longitudinal population-based data. Such norms can be used as reference values to determine where an individual's score lies in relation to his or her age, sex, and education level.
Liposomal antibiotics for the treatment of infectious diseases (2013)

Liposomes are safe and suitable for delivery of variety of molecules and drugs in biomedical research and medicine. They are known to improve the therapeutic index of encapsulated agents and reduce drug toxicity. Recent studies on liposomal formulation of chemotherapeutic and bioactive agents and their targeted delivery show liposomal antibiotics potential in the treatment of microbial infections.
Efficient blue-green and white light-emitting electrochemical cells based on poly[9,9-bis(3,6-dioxaheptyl)-fluorene-2,7-diyl] (1997)

Efficient blue-green polymer light-emitting electrochemical cells, based on poly[9,9-bis(3,6-dioxaheptyl)-fluorene-2,7-diyl] (BDOH-PF), have been demonstrated. BDOH-PF has a high photoluminescent quantum efficiency of 73% photon/photon in solid films. The polyether-type side groups of this polymer are built in to promote the ionic conductivity necessary for the operation of light-emitting electrochemical cells (LECs). Blue-green LECs using a blend of BDOH-PF and lithium triflate as the emissive layer, ITO and Al as the electrodes, achieve an external quantum efficiency of 4% photons/electron and a luminous efficiency of 12 lm/W at 3.1 V. The brightness reaches ∼200 cd/m2 at 3.1 V, and exceeds 1000 cd/m2 at 3.5 V. When additional poly(ethylene oxide) (PEO) is blended into the emissive layer, phase separation between PEO and BDOH-PF occurs, and the emission becomes white. These white emitting LECs reach an external quantum efficiency of 2.4% photons/electron and 400 cd/m2 brightness at a bias of 4 V.
On-line control of a real system with MATLAB/SIMULINK (2002)

An interface routine using C programming language, establishes communication between MATLAB and an I/O card. This enable the user to implement the simulated controller in MATLAB environment to control real-time plant, as well as to utilize the software as a data collection device which records plant output and reference input. With the help of the interface routine, the performance of each controller scheme is recorded and analyzed. This is to enhance control laboratory, by enabling students to design and implement controller via SLMULINK to control a real physical system, and free the lab station from devices such as function generator, oscilloscopes etc.