gebhart/patrepeval huggingface dataset:
Predicting learning status in MOOCs using LSTM (2019)

Real-time and open online course resources of MOOCs have attracted a large number of learners in recent years. However, many new questions were emerging about the high dropout rate of learners. For MOOCs platform, predicting the learning status of MOOCs learners in real time with high accuracy is the crucial task, and it also help improve the quality of MOOCs teaching. The prediction task in this paper is inherently a time series prediction problem, and can be treated as time series classification problem, hence this paper proposed a prediction model based on RNN-LSTMs and optimization techniques which can be used to predict learners' learning status. Using datasets provided by Chinese University MOOCs as the inputs of model, the average accuracy of model's outputs was about 90%.
Analysis of an ankyrin-like region in Epstein Barr Virus encoded (EBV) BZLF-1 (ZEBRA) protein: implications for interactions with NF-κB and p53 (2011)

Viral capture of an ankyrin-like domain provides a mechanism for ZEBRA binding to proteins in the NF-κB and p53 transcription factor families, and also provides support for a process termed "Ping-Pong Evolution" in which DNA viruses such as EBV are formed by exchange of information with the host genome. An amino acid polymorphism in the ZANK region is identified in ZEBRA from tumor cell lines including Akata that could alter binding of Akata ZEBRA to the p53 tumor suppressor and other ankyrin binding protein, and a novel model of antagonistic binding interactions between ZANK and the DNA binding regions of ZEBRA is suggested that may be explored in further biochemical and molecular biological models of viral replication.
A Minimal Solution for Relative Pose with Unknown Focal Length (2005)

Assume that we have two perspective images with known intrinsic parameters except for an unknown common focal length. It is a minimally constrained problem to find the relative orientation between the two images given six corresponding points. We present an efficient solution to the problem and show that there are 15 solutions in general (including complex solutions). To the best of our knowledge this was a previously unsolved problem. The solutions are found through eigen-decomposition of a 15/spl times/15 matrix. The matrix itself is generated in closed form. We demonstrate through practical experiments that the algorithm is correct and numerically stable.
Organophosphorus compounds of sulfur and selenium. Stereochemistry of oxidation of thiono- and selenophosphoryl compounds with hydrogen peroxide (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOrganophosphorus compounds of sulfur and selenium. Stereochemistry of oxidation of thiono- and selenophosphoryl compounds with hydrogen peroxideWojciech J. Stec, Andrzej Okruszek, and Jan MichalskiCite this: J. Org. Chem. 1976, 41, 2, 233–238Publication Date (Print):January 1, 1976Publication History Published online1 May 2002Published inissue 1 January 1976https://pubs.acs.org/doi/10.1021/jo00864a011https://doi.org/10.1021/jo00864a011research-articleACS PublicationsRequest reuse permissionsArticle Views190Altmetric-Citations40LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Differentiation of isomeric amino acid residues in proteins and peptides using mass spectrometry (2012)

Characterization and differentiation of isomers in biological macromolecules using mass spectrometry is one of the most significant challenges facing scientists in the field. The capability of high-resolution MS instruments along with the development of new fragmentation methods now provides the ability to indirectly differentiate between some isomers. This ability has enabled mass spectrometry to evolve into a multidisciplinary technique incorporating areas such as pharmaceutical research, proteomics, polymer science, medicine, environmental chemistry, and recently archeology. This article aims to review recent developments in mass spectrometry methodologies in the identification of structural and spatial isomers in biological macromolecules, such as aspartic acid and isoaspartic acid (Asp/IsoAsp), leucine and isoleucine (Leu/Ile), glutamic acid and γ-glutamic acid, and D/L enantiomers.
Determination of protein regions responsible for interactions of amelogenin with CD63 and LAMP1 (2007)

The enamel matrix protein amelogenin is secreted by ameloblasts into the extracellular space to guide the formation of highly ordered hydroxyapatite mineral crystallites, and, subsequently, is almost completely removed during mineral maturation. Amelogenin interacts with the transmembrane proteins CD63 and LAMP (lysosome-associated membrane protein) 1, which are involved in endocytosis. Exogenously added amelogenin has been observed to move rapidly into CD63/LAMP1-positive vesicles in cultured cells. In the present study, we demonstrate the protein region defined by amino acid residues 103-205 for CD63 interacts not only with amelogenin, but also with other enamel matrix proteins (ameloblastin and enamelin). A detailed characterization of binding regions in amelogenin, CD63 and LAMP1 reveals that the amelogenin region defined by residues PLSPILPELPLEAW is responsible for the interaction with CD63 through residues 165-205, with LAMP1 through residues 226-251, and with the related LAMP2 protein through residues 227-259. We predict that the amelogenin binding region is: (i) hydrophobic; (ii) largely disordered; and (iii) accessible to the external environment. In contrast, the binding region of CD63 is likely to be organized in a '7' shape within the mushroom-like structure of CD63 EC2 (extracellular domain 2). In vivo, the protein interactions between the secreted enamel matrix proteins with the membrane-bound proteins are likely to occur at the specialized secretory surfaces of ameloblast cells called Tomes' processes. Such protein-protein interactions may be required to establish short-term order of the forming matrix and/or to mediate feedback signals to the transcriptional machinery of ameloblasts and/or to remove matrix protein debris during enamel biomineralization.
Sampling circuits that break the kT/C thermal noise limit (2013)

Several circuit-level techniques are described which are used to reduce thermal noise and break the so-called kT/C limit. kT/C noise describes the total thermal noise power added to a signal when a sample is taken on a capacitor. In the first proposed technique, the sampled thermal noise is reduced by altering the relationship between the sampling bandwidth and the dominant noise source, providing a powerful, new degree of freedom in circuit design. In the second proposed technique, thermal noise sampled on an input capacitor is actively cancelled using an amplifier, so that the noise at the amplifier output can be controlled independently of input capacitor size. Measurements from two test chips are presented which demonstrate sampled thermal noise power reduction of up to 70% when compared to conventional kT/C-limited sampling.
TSG-6 Controls Transcription and Activation of Matrix Metalloproteinase 1 in Conjunctivochalasis (2012)

TSG-6 exerts an anti-inflammatory function by counteracting the transcription of MMP-1 and MMP-3 and the activation of MMP-1. Dysfunction of TSG-6 might play a role in the pathogenesis of CCh.
Front-to-backside alignment using resist-patterned etch control and one etching step (1992)

A processing technique that aligns features on the front side of a wafer to those on its backside has been developed for bulk micromachining. A 30 mu m-square and 1.6 mu m-thick diaphragm serves as an alignment pattern. At the same time that the alignment diaphragm is made, much thicker, large-area diaphragms can be partially etched using 'mesh' masking patterns in these areas. The mesh-masking technique exploits the etch-rate differences between
НАШИЯТ ОПИТ ПРИ ЛЕЧЕНИЕТО НА ОТКРИТИТЕ ФРАКТУРИ (1967)

A series of 124 patients with open fractures is reviewed; fractures of the upper limb prevail. In 91 of them emergency operative treatment is imperative and osteosynthesis is carried in 61 - extra-and intramedullary osteosynthesis. The majority of the patients are children and young people aged up to 40 years. Complications as suppuration of soft tissues, osteomyelitis, pseudarthrosis are noted in exceedingly small number of cases with open fractures and therefore the inference is reached that osteosynthesis of open fractures under the protection of antibiotics is a safe procedure. The measures undertaken for enhancing callus formation yield good results.
Treatment of Infected Wounds with the Antimicrobial Peptide D2A21 (2003)

D2A21 antimicrobial peptide demonstrates significant activity compared with controls and standards of therapy. The promising effect of this topical peptide is clearly evident as shown by this study, and its further investigation as a potential agent in the fight against infected or chronic wounds is warranted.
Fgf signalling controls the dorsoventral patterning of the zebrafish embryo (2004)

The establishment of dorsoventral (DV) patterning in vertebrate embryos depends on the morphogenic activity of a group of Tgfbeta superfamily members, the bone morphogenetic proteins (Bmps) (which specify ventral cell fates), and on their interaction with their dorsally secreted cognate inhibitors chordin and noggin. In the zebrafish, genetic analysis has revealed that Bmp2b and Bmp7, as well as their antagonist chordin, are required for proper DV patterning. The expression of Bmp genes is initially activated in the whole blastula. Well before the beginning of gastrulation, Bmp gene expression progressively disappears from the dorsal side to become restricted to the ventral part of the embryo. We show that this early restriction of Bmp gene expression, which occurs independently of noggin and chordin, is an essential step in the establishment of DV patterning. The progressive ventral restriction of Bmp gene transcripts is coincident with the spreading of Fgf activity from the dorsal side of the embryo, suggesting that Fgf signalling is implicated in dorsal downregulation of Bmp gene expression. In accordance with this, activation of the Fgf/Ras/Mapk-signalling pathway inhibits ventral Bmp gene expression, thereby causing a dorsalisation of the embryo. Conversely, inhibition of Fgf signalling causes Bmp gene expression to expand dorsally, leading to an expansion of ventral cell fates. In accordance with an important role of Fgf signalling in the DV patterning of the zebrafish, we show that loss of Fgf8 function enhances the ventralisation of chordin-deficient embryos. Our results thereby demonstrate that pre-gastrula stage Fgf-signalling is essential to delimit the expression domain of the genes encoding the functional morphogen of the dorsoventral axis of the early zebrafish embryo.
New fully differential HF CMOS op amps with efficient common mode feedback (2003)

Conventional fully differential HF CMOS operational amplifiers (op amps) use an extra circuit to perform common-mode feedback (CMFB), which results in signal distortion and/or asymmetry as the signal swing increases. To solve this problem, two fully differential CMOS op amps that are based on merging two single-ended-output op amps are proposed and analyzed. Through the inherent differential-to-single-ended conversion circuitry, CMFB can be efficiently performed without extra circuits. The output signals are not distorted, and the HF performance is not degraded. Simulation and experimental results have confirmed the performance of the proposed new op amps.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Renewable chain transfer agents for metallocene polymerizations: The effects of chiral monoterpenes on the polyolefin molecular weight and isotacticity (2007)

Abstract Monoterpenes were used as renewable chain transfer agents and polymerization solvents for metallocene/methylaluminoxane (MAO) catalysis. The polymerization of 1‐hexene, ethylene, and propylene in d ‐limonene, hydrogenated d ‐limonene and α‐pinene is reported. As detected by 1 H NMR analysis of the alkene region, chain transfer to d ‐limonene yielded a higher percentage of trisubstituted alkenes. Size exclusion chromatography detected a decrease in molecular weight values resulting from chain transfer to d ‐limonene. The [mmmm] pentads for isotactic polypropylene were characterized by 13 C NMR and FTIR spectroscopy. Propylene polymerizations with the Et(Ind) 2 ZrCl 2 /MAO and Me 2 Si(Ind) 2 ZrCl 2 /MAO catalyst systems in d ‐limonene gave [mmmm] pentad values as high as 0.97. For the Et(Ind) 2 ZrCl 2 /MAO catalyst system at 0 °C, the mol fraction of [mmmm] pentads increased from 0.86 to 0.94 upon switching the solvent from toluene to d ‐limonene. © 2007 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 45: 3150–3165, 2007
Intelligence Base Routing in Wireless Networks Using Linux Router (2017)

In today modern life the use of wireless networks have attain a great attraction because in wireless environment the nodes or user can move freely without any physical connection the network resources. The throughput is considering a basic element in this environment. Swarm Intelligent solutions are then analyzed in both wired and wireless networks. Keeping such attitude in view we should try to design and develop such kind of naturally inspired protocols that after simulation be easy to implement as early as possible with low cost factors. Also during the designing and simulation process we should not use such kind of software which is not available for the implementation in real world networks. In our research experiments are conducted in the Linux router real network, in these experiments parameters or values were given same corresponding to virtual machine values. The big advantage of the Linux router is that anyone can change its personal computer to Linux router or gateway after doing some basic configurations. This will helps to make its wireless network for optimization of data traffic. The results or output that we received from the experiments was really beneficent because when we increase the number of repetition then its performance was also increased. This is the best feature of an intelligence based routing protocol that learns from the external working structure and enhance the throughput accordingly.
Evolutionary Design of Generic Green Fluorescent Protein Biosensors (2003)

Protein-engineering techniques have been applied to the molecular design of protein-based biosensors that combine a molecular-recognition site with a signal-transduction function (1). The optical signal-transduction mechanism of green fluorescent protein (GFP) is most attractive, because the fluorophore of GFP is intrinsic to the polypeptide chain, and thus easily applied to molecular imaging in living cells (2). One of the useful methods for creating new molecular-recognition sites on GFPs is a combination of the insertional gene fusion technique with evolutionary biotechnology (3).
A Highly Inducible System of Gene Expression by Positive Feedback Production of Glucocorticoid Receptors (1989)

To investigate the function of a cloned gene, inducible enhancer/promoters are preferred for controlling the level of expression experimentally. Highly inducible gene expression systems with both low basal levels and enhanced maximal levels of expression are especially sought. We have developed a new expression system using a positive feedback mechanism. Glucocorticoid receptor cDNA was fused to the enhancer/promoter of mouse mammary tumor virus (MTV) to induce receptor production. Simultaneous introduction of this receptor plasmid into mouse Ltk- cells augmented the expression of the reporter gene linked with the MTV enhancer/promoter by 10- to 100-fold in an induced state, but did not significantly change the expression of that in an uninduced state. This novel system of gene expression is a good candidate for an efficient genetic switch.
Soil Arching in Sandy Slopes (1986)

Recently soil arching theory has been extended to the study of forces and stresses exerted by a yielding soil mass against discrete piles embedded in a slope and extending into a firm, non‐yielding base. Many uses of discrete pile retaining wall systems exist in current geotechnical practice. In each case, soil arching has been relied upon to some extent as a means of stabilization without concise information about the required spacing of the stabilization piles. This lack of information requires a design engineer to err on the conservative side, and to place the piles closer together than they need be. This study examines the role of soil arching in discrete pile retaining walls and provides an information base for rational design. The present research objective is to experimentally model soil arching action between piles, to determine the influence of and relationships between the essential parameters, and to compare predictions from several new arching theories to experimental model results. The results of the experimental and theoretical comparisons indicate that discrete piles embedded in a slope into a firm, non‐yielding base, can provide significant additional stability to a slope if conditions for soil arching are met. Files can be installed without significantly decreasing slope stability during construction. For retaining walls that rotate vertically about the base between “fixed” side supports, the data obtained by the modified Bransby and Smith numerical method closely approximates experimental results. The stress transfer ability of loose soil is greater than previously thought. A loose deposit does not preclude the possibility of mobilizing soil arching or side friction. In soldier pile and lagging systems, material costs, strengths, and sizes can be optimized to achieve maximum benefit from soil arching.
Physico-chemical Methods. (1934)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhysico-chemical Methods.J. ReillyJ. ReillyMore by J. Reilly and W. N. RaeW. N. RaeMore by W. N. RaeCite this: J. Phys. Chem. 1934, 38, 6, 854Publication Date (Print):June 1, 1934Publication History Published online1 May 2002Published inissue 1 June 1934https://doi.org/10.1021/j150357a017Request reuse permissions Article Views47Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (107 KB) Get e-Alerts
Selective inability of spleen antigen presenting cells from <i>Leishmania donovani</i> infected hamsters to mediate specific T cell proliferation to parasite antigens (1992)

Golden hamsters (Mesocricetus auratus) infected with Leishmania donovani develop a disease similar to human kala-azar. There is conspicuous hypergammaglobulinaemia and their T cells do not respond to stimulation by parasite antigens. The impairment of the cellular immune response seems to be restricted to parasite antigens since infected animals are able to develop a T cell response to the mitogen Concanavalin A (Con-A) and, after sensitization, to the antigens keyhole limpet haemocyanin (KLH) and human serum albumin (DNP-HSA). In the present investigations we studied the role played by infected macrophages in the development of the cellular unresponsiveness present in visceral leishmaniasis. Adherent spleen cells from infected hamsters were unable to present L. donovani antigens to antigen specific T cells, however they were able to present KLH. Conversely, T cells from infected animals did not respond to parasite antigens even when these antigens were presented by normal syngeneic macrophages. Interestingly, lymphocytes from inguinal lymph nodes of infected animals sensitized in their foot pad with parasite antigens proliferated well when stimulated in vitro with L. donovani antigens. These results suggest that the defect in the cellular immune response of the L. donovani infected hamsters is a consequence of a selective inability of their antigen presenting cells to process and present parasite antigens to T cells.
Advanced lane recognition-fusing vision and radar (2002)

One major problem of the common vision-based lane recognition systems is their susceptibility to weather. These problems mainly stem from the fact, that they only look for road structures. From the position of other cars in front, the run of the curve can be estimated. This paper presents our fusion approach, that takes leading vehicles into account which have been detected by radar. The Kalman filter applied here does not only deliver improved measurements of the run of the curve, but also a precise estimate of the lateral position of the observed cars. This information can be used to improve the lane assignment of ACC systems.
Evaluating Soybean Germ Plasm for Brown Stem Rot Resistance (1989)

Over 3.400 accessions from the USDA Soybean Germplasm Collection in maturity groups 000 to IV were evaluated between 1981 and 1984 for resistance to brown stem rot (BSR) caused by Phialophora gregata. Lines were evaluated in naturally infested fields at latitudes to which they were adapted. In 1985 and 1986, 13 early maturity, and 25 late maturity, putatively resistant lines were evaluated in replicated tests. (…)
The prickly lettuce agglutinin. I. Isolation from leaves of the prickly lettuce plant (Lactuca scariole). (1980)

An agglutinin has been isolated from leaves of the prickly lettuce plant (Lactuca scariole). The prickly lettuce agglutinin (PLA) agglutinates erythrocytes of the mouse and rat, and binds to, but does not agglutinate erythrocytes of other species. PLA can be precipitated from crude plant extracts by cold acetone and ammonium sulfate treatment, is sensitive to proteolytic enzyme activity, and contains carbohydrate residues, suggesting that it is a glycoprotein. The agglutinin has a molecular weight of approximately 84,000 as determined by SDS-PAGE studies. The receptor for PLA has not been elucidated but may involve, in part, sialic acid residues.