gebhart/patrepeval huggingface dataset:
The membrane-bound but not the soluble form of human Fas ligand is responsible for its inflammatory activity (2003)

The ectopic expression of Fas ligand (FasL/CD95L) in tissues or tumors induces neutrophil infiltration and the destruction of the tissues or the rejection of tumors. It has been suggested thatthe infiltrated neutrophils are responsible for the latter phenomena. FasL is synthesized as a type II transmembrane protein, and soluble FasL is produced by a proteolytic mechanism from the membrane-bound form. We previously demonstrated that uncleavable membrane-bound FasL of mice induces IL-1β release from inflammatory cells, and suggested that the IL-1β enhances neutrophil infiltration. However, recent papers reported that human soluble FasL is directly chemoattractive to neutrophils in vitro and proposed that the soluble form of FasL is responsible for its inflammatory activity. Therefore, in this report, we investigated which form is responsible for the inflammatory activities of human FasL. We produced tumor cell lines expressing one or both forms of human FasL. Cells expressing both forms or only the membrane-bound form of FasL induced neutrophil infiltration when transplanted into the peritoneal cavity of syngeneic mice, while cells expressing only the soluble form did not. Purified soluble FasL failed to induce neutrophil infiltration in vivo. IL-1β release from inflammatory peritoneal exudate and acceleration of tumor rejection were also mediated by membrane-bound but not soluble FasL. These results indicate that the membrane-bound form of FasL is primarily responsible for its inflammatory activity.
Physical modeling of temperature dependences of SOI CMOS devices and circuits including self-heating (1998)

To simulate and examine temperature and self-heating effects in Silicon-On-Insulator (SOI) devices and circuits, a physical temperature-dependence model is implemented into the SOISPICE fully depleted (FD) and nonfully depleted (NFD) SOI MOSFET models. Due to the physical nature of the device models, the temperature-dependence modeling, which enables a device self-heating option as well, is straightforward and requires no new parameters. The modeling is verified by DC and transient measurements of scaled test devices, and in the process physical insight on floating-body effects in temperature is attained. The utility of the modeling is exemplified with a study of the temperature and self-heating effects in an SOI CMOS NAND ring oscillator. SOISPICE transient simulations of the circuit, with floating and tied bodies, reveal how speed and power depend on ambient temperature, and they predict no significant dynamic self-heating, irrespective of the ambient temperature.
Identification of a polymorphic variant associated with HLA-DQw3 and characterized by specific restriction sites within the DQ beta-chain gene. (1985)

Restriction endonuclease digestion of genomic DNA from 24 lymphoblastoid cell lines homozygous for the HLA class II specificity DQw3, followed by hybridization with a DQ beta-chain cDNA probe, identified a genomic polymorphism with variable BamHI and HindIII recognition sites. This restriction fragment pattern was found for several haplotypes associated with the DQw3 specificity, including some haplotypes positive for the HLA-DR specificities DR4, DR5, DRw8, and DRw12. The variant fragment pattern corresponds precisely with the reactivity of a monoclonal antibody, A-10-83, previously shown to define a serologic split of DQw3. Serologic detection of the specific DQw3.1 genomic polymorphism indicated that the corresponding DQ beta-chain variants are expressed. This polymorphic restriction fragment pattern, then, represents a selective marker for DQ beta-chain genes that appear to define a DQ beta-chain-associated specificity, here called DQw3.1.
JITScope: Protecting web users from control-flow hijacking attacks (2015)

Web browsers are one of the most important enduser applications to browse, retrieve, and present Internet resources. Malicious or compromised resources may endanger Web users by hijacking web browsers to execute arbitrary malicious code in the victims' systems. Unfortunately, the widely-adopted Just-In-Time compilation (JIT) optimization technique, which compiles source code to native code at runtime, significantly increases this risk. By exploiting JIT compiled code, attackers can bypass all currently deployed defenses. In this paper, we systematically investigate threats against JIT compiled code, and the challenges of protecting JIT compiled code. We propose a general defense solution, JITScope, to enforce Control-Flow Integrity (CFI) on both statically compiled and JIT compiled code. Our solution furthermore enforces the W⊕X policy on JIT compiled code, preventing the JIT compiled code from being overwritten by attackers. We show that our prototype implementation of JITScope on the popular Firefox web browser introduces a reasonably low performance overhead, while defeating existing real-world control flow hijacking attacks.
Autofocus Of Sar Imagery Degraded By Ionospheric-Induced Phase Errors (1989)

It has been suggested that synthetic aperture radar (SAR) images obtained from platforms such as SEASAT are subject to potential degradation by ionospheric-induced phase errors. This premise is based upon data from various satellite experiments that indicate large levels of phase scintillation in auroral zone data. Current models for phase errors induced by the ionosphere suggest that the phase error power spectrum is power law. This implies that the resulting phase errors contain significant components up to the Nyquist limit. Traditional sub-aperture based autofocus techniques, designed to correct uncompensated platform motion errors, are inadequate due to their inability to estimate higher order error terms. A new non-parametric phase error correction scheme developed at Sandia National Laboratories, however, has been demonstrated to remove phase errors of arbitrary structure. Consequently, our new algorithm is a viable candidate for correcting ionospheric phase errors. In this paper we show examples of SAR images degraded by simulated ionospheric phase errors. These images demonstrate that such errors cause smearing with complicated sidelobe structure. Restoration of these images via the new algorithm illustrates its superiority to classical sub-aperture based autofocus techniques.
Determination of far-field antenna patterns from near-field measurements (1973)

In many cases, it is impractical or impossible to make antenna pattern measurements on a conventional far-field range; the distance to the radiating far field may be too long, it may be impractical to move the antenna from its operating environment to an antenna range, or the desired amount of pattern data may require too much time on a far-field range. For these and other reasons, it is often desirable or necessary to determine far-field antenna patterns from measurements made in the radiating near-field region; three basic techniques for accomplishing this have proven to be successful. In the first technique, the aperture phase and amplitude distributions are sampled by a scanning field probe, and then the measured distributions are transformed to the far field. In the second technique, a plane wave that is approximately uniform in amplitude is created by a feed and large reflector in the immediate vicinity of the test antenna. And in the third technique, the test antenna is focused within the radiating near-field region, patterns are measured at the reduced range, and then the antenna is refocused to infinity. Each of these techniques is discussed, and the various advantages and limitations of each technique are presented.
The Phononic Lattice Solid With Fluids For Modelling Non-Linear Solid-Fluid Interactions (1994)

The phononic lattice solid has been developed recently as a possible approach for modelling compressional waves in complex solids at the microscopic scale. Rather than directly modelling the wave equation, the microdynamics of quasi-particles is simulated on a discrete lattice. It is comparable with the lattice gas approach to model idealized gas particles but differs fundamentally in that lattice solid particles carry pressure rather than mass and propagate through a heterogeneous medium. Their speed may be space and direction dependent while the speed of lattice gas particles is constant. Furthermore, they may be scattered by medium heterogeneities. Lattice sites in the phononic lattice solid approach are considered to be fixed in space for all time. Lattice site movements (i.e. deformations) induced by the passage of a macroscopic wave are particularly important for a fluid-filled porous medium considering that non-linear solid-fluid interactions are thought to play a role in attenuation mechanisms. We take lattice site movements into account in the phononic lattice solid and name the approach ‘the phononic lattice solid with fluids (PLSF)’ because it could lead to an improved understanding of the effect of solid-fluid interactions in wave propagation problems. The macroscopic limit of the Boltzmann equation for the PLSF yields the acoustic wave equation for heterogeneous media modified by shear and bulk viscosity terms as well as the second-order term in macroscopic velocity (for the PLS) and additional non-linear terms due to the lattice site movements. It is hoped that PLSF numerical simulation studies of waves through digitized rock matrices may lead to an improved understanding of attenuation mechanisms of waves in porous rocks.
Comparison of Interpolation Methods as Applied to Time Synchronous Averaging (1999)

Abstract : Several interpolation techniques were investigated to determine their effect on time synchronous averaging of gear vibration signals and also the effects on standard health monitoring diagnostic parameters. The data was also digitally resampled to determine the effect of lower acquisition rates. The analysis used previously recorded vibration data taken during Health and Usage Monitoring gear testing at the NASA Glenn Research Center. The gear testing monitored the development of surface pitting fatigue on aerospace quality spur gears. Linear, cubic and spline interpolation methods were investigated. Comparisons between the resultant averages show that while there are differences in the resultant time synchronous averages, the differences are not obvious. The diagnostic parameters tested were FM4 and NA4. There are significant differences in the percent deviation curves which imply that the magnitudes of the errors increase as the sample rate decreases.
Managing IoT Cyber-Security Using Programmable Telemetry and Machine Learning (2020)

Cyber-security risks for Internet of Things (IoT) devices sourced from a diversity of vendors and deployed in large numbers, are growing rapidly. Therefore, management of these devices is becoming increasingly important to network operators. Existing network monitoring technologies perform traffic analysis using specialized acceleration on network switches, or full inspection of packets in software, which can be complex, expensive, inflexible, and unscalable. In this paper, we use SDN paradigm combined with machine learning to leverage the benefits of programmable flow-based telemetry with flexible data-driven models to manage IoT devices based on their network activity. Our contributions are three-fold: (1) We analyze traffic traces of 17 real consumer IoT devices collected in our lab over a six-month period and identify a set of traffic flows (per-device) whose time-series attributes computed at multiple timescales (from a minute to an hour) characterize the network behavior of various IoT device types, and their operating states (i.e., booting, actively interacted with user, or being idle); (2) We develop a multi-stage architecture of inference models that use flow-level attributes to automatically distinguish IoT devices from non-IoTs, classify individual types of IoT devices, and identify their states during normal operations. We train our models and validate their efficacy using real traffic traces; and (3) We quantify the trade-off between performance and cost of our solution, and demonstrate how our monitoring scheme can be used in operation for detecting behavioral changes (firmware upgrade or cyber attacks).
Formal Synthesis of 3-Deoxy-<scp>d</scp>-manno-2-Octulosonic Acid (KDO) via a Highly Double-Stereoselective Hetero Diels−Alder Reaction Directed by a (Salen)Co<sup>II</sup> Catalyst and Chiral Diene (1998)

This paper presents a formal total synthesis of 3-deoxy-D-manno-2-octulosonic acid (KDO) based on a highly double-stereoselective hetero Diels-Alder reaction between an electron-rich diene and ethyl glyoxylate catalyzed by (Salen)Co(II) complex, a new catalyst for Diels-Alder reactions. A facial specific hydroboration followed by oxidative workup leads to a diol system with the trans-diequatorial arrangement of hydroxyl groups at the C-4 and C-5. Inversion of the configuration of the C-5 hydroxyl group in 12 and then ketal formation afford the desired target diisopropylidene-2-deoxy-KDO methyl ester (18), which can be converted to KDO according to the literature procedure.
Equine bone marrow-derived mesenchymal stromal cells are heterogeneous in MHC class II expression and capable of inciting an immune response in vitro (2014)

The results of this study suggest that MSCs should be confirmed as MHC class II negative before allogeneic application. Additionally, it must be considered that even MHC class II-negative MSCs could upregulate MHC class II expression if implanted into an area of active inflammation, as demonstrated with in vitro stimulation with IFN-γ.
Validating the Impact on Reducing Fuel Consumption by Using an EcoDriving Assistant Based on Traffic Sign Detection and Optimal Deceleration Patterns (2013)

This paper implements and validates an expert system that, based on the detection or previous knowledge of certain types of traffic signals, proposes a method to reduce fuel consumption by calculating optimal deceleration patterns, minimizing the use of braking. The expert system uses a mobile device's embedded camera to monitor the environment and to recognize certain types of static traffic signals that force or can force a vehicle to stop. The system uses an adaptation of the algorithm proposed by Viola and Jones for the recognition of faces in real time, adapted to the detection of traffic signals. Detected signals are also incorporated into a central database for future use. When the vehicle approaches an upcoming traffic signal, the algorithm estimates the distance required to stop the vehicle without using the brakes, taking into account the rolling resistance coefficient and the road slope angle. Appropriate advice and feedback are provided to the driver to release the accelerator pedal. The expert system is implemented on Android mobile devices and has been validated using a data set of 180 tests with five different models of vehicles and nine different drivers. The main contribution of this paper is the proposal of an assistant that uses information from the environment and from the vehicle to calculate optimal deceleration patterns when approaching traffic signals that force or may force the vehicle to stop. In addition, the proposed solution does not require the installation of infrastructure on the road, and it can be installed into any vehicle.
RET Protooncogene Analysis in the Diagnosis of Medullary Thyroid Carcinoma and Multiple Endocrine Neoplasia Type II (1998)

Department of Pathology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Spain
Digital Asset Management (2012)

The second edition focuses on the media and entertainment sector (M&E), with more information relevant to encompass broadcasters migration to file-based production. New technology and new products are also included and there is more detail on systems integration and product examples, plus extra case studies. New content includes:- Storage management where several products have been designed for the special needs of the media business.- XML and web services.- New case studies.
Production of Fluorocarbons (1949)

A description is herein given of the general method by which fluorocarbons and some of their derivatives are obtained from hydrogen fluoride, an organic compound, and an electric current.
FK506 augments activation-induced programmed cell death of T lymphocytes in vivo. (1995)

FK506 is an immunosuppressive drug that inhibits T cell receptor-mediated signal transduction. This drug can induce immunological tolerance in allograft recipients. In this study, we investigated the in vivo effects of FK506 on T cell receptor-mediated apoptosis induction. Injection of anti-CD3 antibody (Ab) in mice resulted in the elimination of CD4+ CD8+ thymocytes by DNA fragmentation. FK506 treatment significantly augmented thymic apoptosis induced by in vivo anti-CD3 Ab administration. Increased thymic apoptosis resulted in the disappearance of CD4+ CD8+ thymocytes after anti-CD3 Ab/FK506 treatment. DNA fragmentation triggered by FK506 was induced exclusively in antigen-stimulated T cells, since enhanced DNA fragmentation induced by in vivo staphylococcal enterotoxin B (SEB) injection was confirmed in SEB-reactive V beta 8+ thymocytes but not in SEB-nonreactive V beta 6+ thymocytes. In addition to thymocytes, mature peripheral T cells also die by activation-induced programmed cell death. A similar effect of FK506 on activation-induced programmed cell death was observed in SEB-activated peripheral spleen T cells. In contrast, cyclosporin A treatment did not enhance activation-induced programmed cell death of thymocytes and peripheral T cells. Apoptosis is required for the generation and maintenance of self-tolerance in the immune system. Our findings suggest that FK506-triggered apoptosis after elimination of antigen-activated T cells may represent a potential mechanism of the immunological tolerance achieved by FK506 treatment.
The use of ultrasound to accelerate the anaerobic digestion of sewage sludge (1997)

The slow degradation rate of sewage sludge in anaerobic digesters is due to the rate limiting step of sludge hydrolysis. The effect of ultrasound pretreatment on sludge degradability was investigated using ultrasound at a frequency of 31 kHz and high acoustic intensities. Ultrasound treatment resulted in raw sludge disintegration as was demonstrated by increase of Chemical Oxygen Demand in the sludge supernatant and size reduction of sludge solids. Semi-continuous fermentation experiments with disintegrated and untreated sludge were done for four months on a half-technical scale. One fermenter was operated as a control with a conventional residence time of 22 days. Four fermenters were operated with disintegrated sludge and residence times of 22, 16, 12, and 8 days, respectively. In the fermenters operated with identical residence times of 22 days reduction of volatile solids was 45.8% for untreated sludge and 50.3% for disintegrated sludge. The fermentation of disintegrated sludge was stable even at the shortest residence time of 8 days with biogas production 2.2 times that of the control fermenter. Due to ultrasound disintegration a better degradability of raw sludge was achieved that permitted a substantial increase in throughput.
Mitochondrial One-Carbon Metabolism Maintains Redox Balance during Hypoxia (2014)

Mitochondria generate high levels of reactive oxygen species (ROS) to activate protumorigenic signaling pathways. In parallel, the mitochondria must also increase their antioxidant capacity to lower ROS levels and prevent cancer cell death. In this issue of Cancer Discovery, Ye and colleagues demonstrate that serine catabolism through one-carbon metabolism within the mitochondrial matrix is necessary to maintain this redox balance.
Writing Compilers and Interpreters: An Applied Approach Using C++ (1996)

From the Publisher:
Grab hold of your C++ because here you'll learn how to use it to write compilers and interpreters--those programs that translate high-level computer code into machine-executable code. The only C++-based book on compilers and interpreters available, this revised and updated edition shows you the ABC's of reading and listing a program, breaking it into tokens, parsing it, and examining its syntax. Then it shows you how to build an actual interpreter, debugger, and finally, a compiler.
Positive Regulators of Opine-Inducible Promoters in the Nopaline and Octopine Catabolism Regions of Ti Plasmids (1991)

The noc and occ regions of nopaline and octopine Ti plasmids in Agrobacterium tumefaciens contain genes for the catabolism of nopaline and octopine, respectively. We investigated the transcriptional organization and regulation of both regions. The noc region of pTiC58 contains two nopaline-inducible promoters, and one octopine-inducible promoter was identified in the occ region of pTiAch5. All three promoters are positively regulated in trans by constitutively expressed genes localized at the right end of the regions. The DNA sequence analysis of these parts revealed genes coding for related proteins (35.6% identity). The two polypeptides share significant similarity with a family of other positive gene regulators, and both contain a protein motif ("LysR" signature) that is characteristic for the DNA binding domain in these polypeptides. These proteins are the only Ti plasmid functions necessary for the activation of the opine-induced promoters. We propose the names nocR and occR for the regulator genes in the noc and in the occ regions.
Design optimisation of the deep trench termination for superjunction power devices (2015)

International audience
Data Structures in Kernel Density Estimation (1985)

We analyze and compare several data structures and algorithms for evaluating the kernel density estimate. Frequent evaluations of this estimate are for example needed for plotting, error estimation, Monte Carlo estimation of probabilities and functionals, and pattern classification. An experimental comparison is included.
Oral Complications of Cancer Chemotherapy: Present Status and Future Studies (1982)

No AccessJournal of Urology1 Dec 1982Oral Complications of Cancer Chemotherapy: Present Status and Future Studies D.E. Peterson, and S.T. Sonis D.E. PetersonD.E. Peterson More articles by this author , and S.T. SonisS.T. Sonis More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)53548-XAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Oral Complications of Cancer Chemotherapy: Present Status and Future Studies." The Journal of Urology, 128(6), p. 1419 © 1982 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 128Issue 6December 1982Page: 1419 Advertisement Copyright & Permissions© 1982 by The American Urological Association Education and Research, Inc.MetricsAuthor Information D.E. Peterson More articles by this author S.T. Sonis More articles by this author Expand All Advertisement PDF DownloadLoading ...