gebhart/patrepeval huggingface dataset:
Antibodies to TRIC Agents in Tears and Serum of Naturally Infected Humans (1973)

Antibodies to six trachoina-inclusion conjunctivitis (TRIC) antigens were measured by indirect immunofluorescence in matched specimens of serum and tears from individuals with chronic trachoma. Antibodies (to TRIC antigens type A and/or C) were present in the serum of 78% of Tunisian children, six to eight years old, with severe trachoma and in the tears of 59%. In contrast, antibodies (to TRIC antigens type B, D, and E) were found in the serum and tears of only 6% of Navajo children of similar age with mild trachoma. Among Navajo students 13–20 years old with mild trachoma, 48% had antibodies (to antigens B, D, and E) in serum, but antibodies in tears were very rare. These were usually of lower titer than those in serum, were directed at the same TRIC antigenic types, and paralleled the severity of clinical activity in TRIC infections. The role of lachrymal antibodies in resistance to TRIC infection is not apparent.
Genetic variation in the 22q11 locus and susceptibility to schizophrenia (2002)

An increased prevalence of microdeletions at the 22q11 locus has been reported in samples of patients with schizophrenia. 22q11 microdeletions represent the highest known genetic risk factor for the development of schizophrenia, second only to that of the monozygotic cotwin of an affected individual or the offspring of two schizophrenic parents. It is therefore clear that a schizophrenia susceptibility locus maps to chromosome 22q11. In light of evidence for suggestive linkage for schizophrenia in this region, we hypothesized that, whereas deletions of chromosome 22q11 may account for only a small proportion of schizophrenia cases in the general population (up to approximately 2%), nondeletion variants of individual genes within the 22q11 region may make a larger contribution to susceptibility to schizophrenia in the wider population. By studying a dense collection of markers (average one single nucleotide polymorphism20 kb over 1.5 Mb) in the vicinity of the 22q11 locus, in both family- and population-based samples, we present here results consistent with this assumption. Moreover, our results are consistent with contribution from more than one gene to the strikingly increased disease risk associated with this locus. Finer-scale haplotype mapping has identified two subregions within the 1.5-Mb locus that are likely to harbor candidate schizophrenia susceptibility genes.
Tumor Necrosis Factor-α Is a Potent Endogenous Mutagen that Promotes Cellular Transformation (2006)

Tumor necrosis factor-alpha (TNF-alpha) is an important inflammation cytokine without known direct effect on DNA. In this study, we found that TNF-alpha can cause DNA damages through reactive oxygen species. The mutagenic effect of TNF-alpha is comparable with that of ionizing radiation. TNF-alpha treatment in cultured cells resulted in increased gene mutations, gene amplification, micronuclei formation, and chromosomal instability. Antioxidants significantly reduced TNF-alpha-induced genetic damage. TNF-alpha also induced oxidative stress and nucleotide damages in mouse tissues in vivo. Moreover, TNF-alpha treatment alone led to increased malignant transformation of mouse embryo fibroblasts, which could be partially suppressed by antioxidants. As TNF-alpha is involved in chronic inflammatory diseases, such as chronic hepatitis, ulcerative colitis, and chronic skin ulcers, and these diseases predispose the patients to cancer development, our results suggest a novel pathway through which TNF-alpha promotes cancer development through induction of gene mutations, in addition to the previously reported mechanisms, in which nuclear factor-kappaB activation was implicated.
Synchronized delta oscillations correlate with the resting-state functional MRI signal (2007)

Synchronized low-frequency spontaneous fluctuations of the functional MRI (fMRI) signal have recently been applied to investigate large-scale neuronal networks of the brain in the absence of specific task instructions. However, the underlying neural mechanisms of these fluctuations remain largely unknown. To this end, electrophysiological recordings and resting-state fMRI measurements were conducted in alpha-chloralose-anesthetized rats. Using a seed-voxel analysis strategy, region-specific, anesthetic dose-dependent fMRI resting-state functional connectivity was detected in bilateral primary somatosensory cortex (S1FL) of the resting brain. Cortical electroencephalographic signals were also recorded from bilateral S1FL; a visual cortex locus served as a control site. Results demonstrate that, unlike the evoked fMRI response that correlates with power changes in the gamma bands, the resting-state fMRI signal correlates with the power coherence in low-frequency bands, particularly the delta band. These data indicate that hemodynamic fMRI signal differentially registers specific electrical oscillatory frequency band activity, suggesting that fMRI may be able to distinguish the ongoing from the evoked activity of the brain.
Constraint-based scheduling (1991)

The GERRY scheduling system developed by NASA Ames with assistance from the Lockheed Space Operations Company, and the Lockheed Artificial Intelligence Center, uses a method called constraint-based iterative repair. Using this technique, one encodes both hard rules and preference criteria into data structures called constraints. GERRY repeatedly attempts to improve schedules by seeking repairs for violated constraints. The system provides a general scheduling framework which is being tested on two NASA applications. The larger of the two is the Space Shuttle Ground Processing problem which entails the scheduling of all the inspection, repair, and maintenance tasks required to prepare the orbiter for flight. The other application involves power allocation for the NASA Ames wind tunnels. Here the system will be used to schedule wind tunnel tests with the goal of minimizing power costs. In this paper, we describe the GERRY system and its application to the Space Shuttle problem. We also speculate as to how the system would be used for manufacturing, transportation, and military problems.
Properties of Metallic Nanowires: From Conductance Quantization to Localization (1995)

Material structures of reduced dimensions exhibit electrical and mechanical properties different from those in the bulk. Measurements of room-temperature electronic transport in pulled metallic nanowires are presented, demonstrating that the conductance characteristics depend on the length, lateral dimensions, state and degree of disorder, and elongation mechanism of the wire. Conductance during the elongation of short wires (length l approximately 50 angstroms) exhibits periodic quantization steps with characteristic dips, correlating with the order-disorder states of layers of atoms in the wire predicted by molecular dynamics simulations. The resistance R of wires as long as l approximately 400 angstroms exhibits localization characteristics with In R(l) approximately l(2).
Dependence of thermal resistance on ambient and actual temperature (2004)

We investigate the temperature dependence of thermal resistance. We extract the thermal resistance as a function of ambient temperature. The increase of thermal resistance due to self-heating leads to a non-linear relation between temperature and power dissipation. We show how to implement this in a compact model and what its effect is on simulations at high power dissipation.
Entomology and Human Welfare (1965)

The subject I have chosen to speak on this morning is one that has been much discussed. We who have made entomology our field of endeavor like to evaluate our past accomplishments, and speculate as to what we may be able to accomplish in the future. That is what, in a very general way, I propose to do this morning.
Electronic tuning of arylnickel(II) complexes by para substitution of the terdentate monoanionic 2,6-bis[(dimethylamino)methyl]phenyl ligand (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectronic tuning of arylnickel(II) complexes by para substitution of the terdentate monoanionic 2,6-bis[(dimethylamino)methyl]phenyl ligandLucia A. van de Kuil, Henri Luitjes, David M. Grove, Jan W. Zwikker, Johannes G. M. van der Linden, Annie M. Roelofsen, Leonardus W. Jenneskens, Wiendelt Drenth, and Gerard van KotenCite this: Organometallics 1994, 13, 2, 468–477Publication Date (Print):February 1, 1994Publication History Published online1 May 2002Published inissue 1 February 1994https://pubs.acs.org/doi/10.1021/om00014a020https://doi.org/10.1021/om00014a020research-articleACS PublicationsRequest reuse permissionsArticle Views1018Altmetric-Citations116LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Small Cause, Great Impact: Modification of the Guanidine Group in the RGD Motif Controls Integrin Subtype Selectivity (2015)

Due to its unique role as a hydrogen-bond donor and its positive charge, the guanidine group is an important pharmacophoric group and often used in synthetic ligands. The chemical modification of the guanidine group is often considered to destroy its function. Herein, we show that the N-methylation, N-alkylation, or N-acylation of the guanidine group can be used to modify the receptor subtype specificity of the integrin ligand cilengitide. Using the αvβ6/α5β1-biselective ligand c(isoDGRkphg) and the αvβ6-specific ligand c(FRGDLAFp(NMe)K(Ac) as examples, we show that the binding affinities of the ligands can be fine-tuned by this method to enhance the selectivity for αvβ6. Furthermore, we describe a new strategy for the functionalization of integrin ligands. By introducing longer N-alkylguanidine and N-acylguanidine groups, we are able to simultaneously identify a hitherto unknown anchoring point and enhance the subtype selectivity of the ligand.
Polymer-Dispersed Liquid Crystals (1990)

Polymer-dispersed liquid crystals (PDLCs) are electrooptic materials that modulate light through electrical control of the refractive index similar to other liquid devices. Like dynamic scattering and smectic displays, PDLCs switch between scattering and clear states. PDLC-type devices consist of droplets of low-molecular weight liquid crystals dispersed in a solid polymer binder. They do not require polarizers and have a number of other unique advantages: ease of fabrication, suitability for large area devices, environmental stability and fast switching speeds. PDLCs may be tailored for a wide variety of applications, ranging from architectural glass to projection TV and shutters for infrared video cameras.
Role of Magnesium Silicates in Wet-Kneaded Silica–Magnesia Catalysts for the Lebedev Ethanol-to-Butadiene Process (2016)

Wet-kneading is a technique commonly used for the synthesis of SiO2–MgO catalysts for the Lebedev ethanol-to-butadiene process, with catalyst performance known to depend heavily on the preparation parameters used in this method. Here, the large influence of Mg precursor and MgO content on morphology, chemical structure (as determined by TEM(-EDX), FT-IR, XRD and solid-state 1H–29Si cross-polarized MAS NMR), and on catalyst performance is demonstrated. The Mg precursor used is found to influence the extent of magnesium silicate formation during wet-kneading, as estimated from TEM and FT-IR, which, in turn, was found to correlate with catalyst performance. Accordingly, the catalyst synthesized from a nanosized Mg(OH)2 precursor (SiO2–MgO (III)nano), showing the highest degree of chemical contact between the SiO2 and MgO components, gave the highest butadiene yield. Variation of the Mg/Si ratio in a series of SiO2–MgO (III)nano materials showed a volcano-type dependence of the butadiene yield on MgO content. 1H–29Si CP-MAS NMR studies allowed for the identification of the type and an estimation of the amount of magnesium silicates formed during wet-kneading. Here, we argue that the structural characteristics of the hydrous magnesium silicates, lizardite and talc, formed during catalyst preparation, together with the ratio of the magnesium silicates to MgO, determine the overall acid/base properties of the SiO2–MgO (III)nano catalyst materials and as a result, catalyst performance.
The optical modelling and design of Fabry Perot Interferometer sensors for ultrasound detection (2014)

The work in this thesis documents the optical modelling and design of Fabry Perot Interferometer (FPI) sensors for the detection of ultrasonic waves. The ultrasonic waves modulate the optical phase of the beam through a change in the cavity spacing of the FPI sensor. The optical sensitivity is defined as the change in the reflected light per unit change in the cavity thickness. An optical model to simulate Interferometer Transfer Functions (ITFs) for a Gaussian beam propagating in a Fabry Perot Interferometer is implemented. An understanding of the Gaussian beam phase propagation in a Fabry Perot Interferometer is presented to help in explaining the shape of ITFs simulated. The model is experimentally validated. The model is applied as a design tool for the purpose of optimising FPI sensors. This is achieved by choosing the beam radii, mirror reflectivities and cavity spacing’s which lead to high optical sensitivity. A FPI sensor with high optical sensitivity and pressure linearity is achieved. A high pressure linearity can be achieved by creating a highly asymmetric ITF, by a combination of a highly diverging beam and aperturing the reflected beam. The understanding presented in this work helps in designing optimised FPI sensors for ultrasound detection, as well as in providing a general understanding of the effects of Gaussian beams or other types of divergent beams illuminating FPIs.
Unraveling the Story of NGF-mediated Sensitization of Nociceptive Sensory Neurons: ON or OFF the Trks? (2007)

Nerve Growth Factor (NGF) is produced by and affects a number of immune and inflammatory cells. As part of the inflammatory response, NGF directly or indirectly alters the sensitivity of small diameter sensory neurons that communicate noxious information. The question remains as to the receptors and intracellular signaling cascades that mediate this sensitizing action of NGF. Although the general consensus is that NGF produces peripheral sensitization by activating TrkA, recent work suggests that p75 also contributes. Thus, both NGF receptors appear to contribute to peripheral sensitization although whether they act independently or together remains to be determined. Furthermore, controversy exists as to the downstream signaling pathways involved in NGF-induced peripheral sensitization.
Packrat parsing: (2002)

Packrat parsing is a novel technique for implementing parsers in a lazy functional programming language. A packrat parser provides the power and flexibility of top-down parsing with backtracking and unlimited lookahead, but nevertheless guarantees linear parse time. Any language defined by an LL(k) or LR(k) grammar can be recognized by a packrat parser, in addition to many languages that conventional linear-time algorithms do not support. This additional power simplifies the handling of common syntactic idioms such as the widespread but troublesome longest-match rule, enables the use of sophisticated disambiguation strategies such as syntactic and semantic predicates, provides better grammar composition properties, and allows lexical analysis to be integrated seamlessly into parsing. Yet despite its power, packrat parsing shares the same simplicity and elegance as recursive descent parsing; in fact converting a backtracking recursive descent parser into a linear-time packrat parser often involves only a fairly straightforward structural change. This paper describes packrat parsing informally with emphasis on its use in practical applications, and explores its advantages and disadvantages with respect to the more conventional alternatives.
BLTRCNN-Based 3-D Articulatory Movement Prediction: Learning Articulatory Synchronicity From Both Text and Audio Inputs (2018)

Predicting articulatory movements from audio or text has diverse applications, such as speech visualization. Various approaches have been proposed to solve the acoustic-articulatory mapping problem. However, their precision is not high enough with only acoustic features available. Recently, deep neural network (DNN) has brought tremendous success in various fields, like speech recognition and image processing. To increase the accuracy, we propose a new network architecture for articulatory movement prediction with both text and audio inputs, called a bottleneck long-term recurrent convolutional neural network (BLTRCNN). To the best of our knowledge, it is the first time to predict articulatory movements based on DNN by fusing text and audio inputs. Our BLTRCNN consists of two networks. The first is the bottleneck network, generating a compact bottleneck features of text information for each frame independently. The second, including convolutional neural network, long short-term memory and skip connection, is called the long-term recurrent convolutional neural network (LTRCNN). LTRCNN is used for articulatory movement prediction when bottleneck features, acoustic features, and text features are integrated as inputs together. Experiments show that the proposed BLTRCNN achieves the state-of-the-art root-mean-square error (RMSE) 0.528 mm and the correlation coefficient 0.961. Moreover, we also demonstrate how text information complements acoustic features in this prediction task.
VITAMIN B<sub>12</sub>. XXI. CRYSTALLINE α-RIBAZOLE PHOSPHATE AND ITS SYNTHESIS (1952)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTVITAMIN B12. XXI. CRYSTALLINE α-RIBAZOLE PHOSPHATE AND ITS SYNTHESISEdward A. Kaczka, Dorothea Heyl, William H. Jones, and Karl FolkersCite this: J. Am. Chem. Soc. 1952, 74, 21, 5549–5550Publication Date (Print):November 1, 1952Publication History Published online1 May 2002Published inissue 1 November 1952https://pubs.acs.org/doi/10.1021/ja01141a536https://doi.org/10.1021/ja01141a536research-articleACS PublicationsRequest reuse permissionsArticle Views38Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Synthesis of All Possible Canonical (3′–5′-Linked) Cyclic Dinucleotides and Evaluation of Riboswitch Interactions and Immune-Stimulatory Effects (2017)

The cyclic dinucleotides (CDNs) c-di-GMP, c-di-AMP, and c-AMP-GMP are widely utilized as second messengers in bacteria, where they signal lifestyle changes such as motility and biofilm formation, cell wall and membrane homeostasis, virulence, and exo-electrogenesis. For all known bacterial CDNs, specific riboswitches have been identified that alter gene expression in response to the second messengers. In addition, bacterial CDNs trigger potent immune responses, making them attractive as adjuvants in immune therapies. Besides the three naturally occurring CDNs, seven further CDNs containing canonical 3'-5'-linkages are possible by combining the four natural ribonucleotides. Herein, we have synthesized all ten possible combinations of 3'-5'-linked CDNs. The binding affinity of novel CDNs and GEMM riboswitch variants was assessed utilizing a spinach aptamer fluorescence assay and in-line probing assays. The immune-stimulatory effect of CDNs was evaluated by induction of type I interferons (IFNs), and a novel CDN c-AMP-CMP was identified as a new immune-stimulatory agent.
A Band Extension Technique for G.711 Speech Using Steganography (2006)

This study investigates a band extension technique for speech data encoded with G.711, the most common codec for digital speech communications system such as VoIP. The proposed technique employs steganography for the transmission of the side information required for the band extension. Due to the steganography, the proposed technique is able to enhance the speech quality without an increase of the amount of data transmission. From the results of a subjective experiment, it is indicated that the proposed technique may potentially be useful for improving the speech quality, compared with the conventional technique.
Minichromosome assembly of non-integrated plasmid DNA transfected into mammalian cells (1985)

The nucleoprotein structures formed on various plasmid expression vectors transfected into mammalian cells by both the calcium phosphate and DEAE-dextran methods have been studied. We demonstrate by a variety of means that mammalian cells are capable of rapidly assembling non-integrated circular plasmids (both replicating and non-replicating) into typical "minichromosomes" containing nucleosomes with a 190 bp repetitive spacing. Treatment of recipient cells with sodium butyrate for a short period of time (12-16 h) immediately following transfection markedly increased the DNase I digestion sensitivity of the newly assembled plasmid chromatin. Furthermore, minichromosomes isolated from such butyrate-treated cells are depleted in histone H1 and contain highly acetylated forms of histone H4. These findings are entirely consistent with our earlier speculation (Gorman et al., Nucleic Acids Res. 11, 1044; 1983) that appropriate butyrate treatment might stimulate transient expression of newly transfected genes by facilitating their assembly into an "active" type of chromatin structure.
Pulsar timing and relativistic gravity (1993)

Measurements of the times of arrival of pulsar signals at Earth provide uniquely powerful tools for experiments in relativistic gravity. The results of such experiments improve rapidly as the span of repeated observations lengthens, and in one instance the relevant data span is now approaching 20 years. The author briefly summarizes and updates two of the most important results of pulsar timing experiments pertinent to relativity and gravitation. The rate of orbital period decay of binary pulsar PSR B1913+16 has been measured with accuracy 0.35%, and is found to be in excellent accord with the prediction for gravitational radiation damping in general relativity. A more recently discovered binary pulsar system, PSR B1534+12 has provided a unique test of strong-field gravitational effects-and these results, too, are fully consistent with relativity.