gebhart/patrepeval huggingface dataset:
Oral Metoclopramide With or Without Diphenhydramine: Potential for Prevention of Late Nausea and Vomiting Induced by Cisplatin (1988)

Late nausea and vomiting lasting 2-7 days occurs in 20%-68% of patients receiving cisplatin. We therefore studied the effects of oral metoclopramide given at doses of 20, 50, or 100 mg four times a day for 25 doses (7 days) beginning after cisplatin to determine the maximum tolerated dose (MTD) for prophylactic oral antiemetic regimens. Patients were stratified into younger (less than or equal to 30 yr old) and older (greater than 30 yr old) groups. Dose escalation was performed without or with concomitant oral diphenhydramine. For the younger group, the MTD for metoclopramide without diphenhydramine was less than 20 mg, and the MTD with diphenhydramine was 20 mg. For the older group, the MTD without diphenhydramine was 20 mg, and the MTD with diphenhydramine was 50 mg. Extrapyramidal reactions in the younger group and agitated depression in the older group were the major dose-terminating toxic effects. Patient acceptance of these regimens was excellent.
Practical analysis of 3-D dynamic nonlinear magnetic field using time-periodic finite element method (1995)

A practical 3-D finite element method using edge elements for analyzing stationary nonlinear magnetic fields with eddy currents in electric apparatus, in which the flux interlinking the voltage winding is given, has been proposed. The method is applied to the analysis of magnetic fields in the Epstein frame.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Haptic interaction with virtual environment using an arm type exoskeleton device (2004)

Haptic rendering has the potential to increase the quality of human-computer interaction with virtual environment by accommodating the sense of touch. In this paper, a 7 DOF arm type exoskeleton device is designed and implemented. Human user can haptically interact with virtual environment by using this light-weight device. The principles of measuring user's arm motions are presented, which include the dimensional mechanism. The motion of each joint of the proposed haptic device is nearly independent. The virtual contact force is also calculated in real time to meet the stringent requirement of real time haptic rendering. Experiments results show promising feasibility of the arm type exoskeleton device.
Parallel optical network interconnects (2003)

Parallel optical interconnects can provide a competitive physical-layer solution for high-performance multi-processor cluster applications. Successful system insertion requires an efficient interface between CMOS electronics and optical components. The authors explore the use of parallel fiber-optics and single-chip CMOS interface solutions to construct broadband network interconnects. The development of a shared medium ring network to support high-performance multimedia applications is discussed.
Testing in Mice the Hypothesis That Melanin Is Protective in Malaria Infections (2012)

Malaria has had the largest impact of any infectious disease on shaping the human genome, exerting enormous selective pressure on genes that improve survival in severe malaria infections. Modern humans originated in Africa and lost skin melanization as they migrated to temperate regions of the globe. Although it is well documented that loss of melanization improved cutaneous Vitamin D synthesis, melanin plays an evolutionary ancient role in insect immunity to malaria and in some instances melanin has been implicated to play an immunoregulatory role in vertebrates. Thus, we tested the hypothesis that melanization may be protective in malaria infections using mouse models. Congenic C57BL/6 mice that differed only in the gene encoding tyrosinase, a key enzyme in the synthesis of melanin, showed no difference in the clinical course of infection by Plasmodium yoelii 17XL, that causes severe anemia, Plasmodium berghei ANKA, that causes severe cerebral malaria or Plasmodium chabaudi AS that causes uncomplicated chronic disease. Moreover, neither genetic deficiencies in vitamin D synthesis nor vitamin D supplementation had an effect on survival in cerebral malaria. Taken together, these results indicate that neither melanin nor vitamin D production improve survival in severe malaria.
A method of focused crawling for software components (2011)

The number of vertical search engines has rapidly increased over the last years, making the importance of a focused crawler. This paper introduces design and implementation of a focused crawler for software components. Before computing the similarity of a page to the topic, analyze its URL whether it is necessary or not. This leads to significant savings in hardware and network resources, and help the crawler avoid irrelevant page's similarity computation.
Molecular structure in relation to oestrogenic activity. Compounds without a phenanthrene nucleus (1938)

Abstract In earlier publications the oestrogenic activity of a number of synthetic substances has been discussed. The first compounds to be tested contained the phenanthrene ring system, and it was shown (Cook, Dodds and Hewett 1933; Cook and Dodds 1933; Cook, Dodds, Hewett and Lawson 1934; Cook, Dodds and Greenwood 1934) that a high degree of activity is possessed by 9 : 10-dihydroxy-9 : 10-di-n-propyl-9 : 10-dihydro-1 : 2 : 5 : 6-dibenzanthracene. Potency was also observed in the highly unsaturated aliphatic acid, clupanodonic acid, whilst a feeble but definite oestrogenic action was found to be possessed by calciferol. Since neither of these compounds contains the phenanthrene ring system, it was considered that this was not essential for oestrogenic properties. A further interesting observation was made in the partial activity of 1-keto-1: 2: 3: 4: 5: 6: 7: 8-octahydroanthracene. This substance produced an advanced pro-oestrus, but full cornification could not be produced no matter how much of the material was administered. A series of derivatives of acenaphthene was studied because these compounds contain a three-ring system arranged in a manner different from that in phenanthrene. These were tested on ovariectomized rats in the manner described in the above-mentioned publications. Table I shows the results obtained with this group of substances. It will be observed that the most potent member of the series is 1 : 2-dihydroxy-1 : 2-di-α-naphthyl acenaphthene. In doses of 10 mg. this compound produces prolonged oestrus. This new substance confirmed our assumption that the phenanthrene ring system was unnecessary for oestrogenic activity and led to experiments with a number of aromatic carbinols (Table II). This series of compounds showed surprising differences in behaviour. Thus, whilst diphenyl-α-naphthyl carbinol possesses full activity in doses of 100 mg. the corresponding diphenyl-β-naphthyl carbinol and triphenyl carbinol were both without action. The effect of hydroxy groups in the aromatic nucleus was then studied and several phenolic diphenyl methane derivatives were investigated with results as shown in Table III. 3 : 3′- and 4 : 4′- dihydroxydiphenyl methane both showed activity, the latter much greater than the former, but the corresponding dicarboxylic acids were without effect. Many potent substances were found in derivatives of 4 : 4′ dihydroxy-diphenyl methane. From this series it appears that the alkyl substituents on the central carbon atom have no influence on the efficacy of the substance. A single phenyl nucleus has a distinct depressing action, and the diphenyl derivative is completely inert. The introduction of methyl groups in the 3 : 3′ positions appears to diminish the potency in some cases.
A realistic variable voltage scheduling model for real-time applications (2002)

Voltage scheduling is indispensable for exploiting the benefit of variable voltage processors. Though extensive research has been done in this area, current processor limitations such as transition overhead and voltage level discretization are often considered insignificant and are typically ignored. We show that for hard, real-time applications, disregarding such details can lead to sub-optimal or even invalid results. We propose two algorithms that guarantee valid solutions. The first is a greedy yet simple approach, while the second is more complex but significantly reduces energy consumption under certain conditions. Through experimental results on both real and randomly generated systems, we show the effectiveness of both algorithms, and explore what conditions make it beneficial to use the complex algorithm over the basic one.
Cell‐to‐cell transmission of <i>C9orf72</i> poly‐(Gly‐Ala) triggers key features of <scp>ALS</scp> / <scp>FTD</scp> (2020)

The C9orf72 repeat expansion causes amyotrophic lateral sclerosis and frontotemporal dementia, but the poor correlation between C9orf72-specific pathology and TDP-43 pathology linked to neurodegeneration hinders targeted therapeutic development. Here, we addressed the role of the aggregating dipeptide repeat proteins resulting from unconventional translation of the repeat in all reading frames. Poly-GA promoted cytoplasmic mislocalization and aggregation of TDP-43 non-cell-autonomously, and anti-GA antibodies ameliorated TDP-43 mislocalization in both donor and receiver cells. Cell-to-cell transmission of poly-GA inhibited proteasome function in neighboring cells. Importantly, proteasome inhibition led to the accumulation of TDP-43 ubiquitinated within the nuclear localization signal (NLS) at lysine 95. Mutagenesis of this ubiquitination site completely blocked poly-GA-dependent mislocalization of TDP-43. Boosting proteasome function with rolipram reduced both poly-GA and TDP-43 aggregation. Our data from cell lines, primary neurons, transgenic mice, and patient tissue suggest that poly-GA promotes TDP-43 aggregation by inhibiting the proteasome cell-autonomously and non-cell-autonomously, which can be prevented by inhibiting poly-GA transmission with antibodies or boosting proteasome activity with rolipram.
Prostaglandin E acts at two levels to enhance colony formation in vitro by erythroid (BFU-E) progenitor cells. (1987)

The prostaglandin E (PGE) enhancement of erythroid colony formation by human bone marrow erythroid progenitor cells (BFU-E) is mediated by a T8+ subset of lymphocytes. Medium was conditioned by bone marrow and blood T-lymphocytes and T-lymphocyte subsets (T8+, T8-, T4+, and T4- cells) in the absence or presence of PGE1 in order to determine if the cells could release a cell-free source of erythroid colony enhancing activity and what the conditions for this release would be. The T-lymphocyte conditioned medium was assayed for its effects on erythroid colony formation by nonadherent low-density T-lymphocyte depleted (NALT-) bone marrow cells plated in the presence of erythropoietin, hemin, phytohemagglutinin-stimulated leukocyte conditioned medium, or medium conditioned by 5637 cells, in the absence or presence of PGE1 and in the presence or absence of serum. PGE1 induced the release of an erythroid colony enhancing activity from the T8+ and T4-, but not from the T8- and T4+ subsets of lymphocytes, but this cell-free source of activity was only apparent if it was tested for colony formation in the presence of added PGE1. The release and action of the PGE1 induced T-lymphocyte erythroid enhancing activity did not require the presence of serum. Erythroid colony formation by NALT- bone marrow cells was not enhanced by PGE1 alone, by medium conditioned by T-lymphocytes in the absence of PGE1, or by PGE1 plus medium conditioned by T-lymphocytes in the absence of PGE1. The results suggest that the PGE1 enhancement of erythroid colony formation occurs by an apparently synergistic action on non-T-lymphocytes by PGE1 itself and by a factor or factors released from T8+ lymphocytes in response to PGE1.
Context-Aware Cloud Robotics for Material Handling in Cognitive Industrial Internet of Things (2017)

In the context of Industry 4.0, industrial robotics such as automated guided vehicles have drawn increased attention due to their automation capabilities and low cost. With the support of cognitive technologies for industrial Internet of Things (IoT), production processes can be significantly optimized and more intelligent manufacturing can be implemented for smart factories. In this paper, for advanced material handling, a cognitive industrial entity called context-aware cloud robotics (CACR) are introduced and analyzed. Compared with the one-time on-demand delivery, CACR is characterized by two features: (1) context-aware services and (2) effective load balancing. First, the system architecture, advantages, challenges, and applications for CACR are introduced. Then, fundamental functions for material handling are articulated, namely, decisionmaking mechanisms and cloud-enabled simultaneous localization and mapping. Finally, a CACR case study is performed to highlight its energy-efficient and cost-saving material handling capabilities. Simulations indicate the superiority of cognitive industrial IoT and show that using CACR for material handling can significantly improve energy efficiency and save cost.
Block jam (2002)

Block Jam is a musical interface controlled by the arrangement of 24 tangible blocks. By positioning the blocks (Figure 1), musical phrases and sequences are created, allowing multiple users to play and collaborate.
Determination of neutral and amino sugars in glycoproteins by gas chromatography. (1976)

A gas chromatographic method for the determination of neutral and amino sugars in glycoproteins was developed by using trifluoroacetyl derivatives of sugar alcohols and by selecting trifluoroacetic acid as acid catalyst for hydrolysis. The method is as follows : As the hydrolytic condition, 2.5 N TFA, 100°, 7 hr was common to obtain excellent recovery of neutral and amino sugars in many glycoproteins. In the case of having enough sample, it was recommendable to select 4 and 7 hr for hydrolysis of neutral sugars and 7 and 10 hr for amino sugars. In sample preparation for gas chromatography, sugars were reduced with sodium borohydride to corresponding sugar alcohols and trifluoroacetylated with trifluoroacetic anhydride in ethyl acetate. This method was further improved for micro-analysis of sugars in glycoproteins, taking full advantage of the sensitivity of an electron capture detector (ECD) to trifluoroacetyl derivatives. Consequently, it was suggested to be able to analyze constituent neutral and amino sugars in microgram amounts of glycoproteins.
Poly(arylene ether)s via Nitro Displacement Reaction:  Synthesis of Poly(biphenylene oxide)s Containing Trifluoromethyl Groups from AB Type Monomers (2000)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTPoly(arylene ether)s via Nitro Displacement Reaction: Synthesis of Poly(biphenylene oxide)s Containing Trifluoromethyl Groups from AB Type MonomersIm Sik Chung and Sang Youl KimView Author Information Center for Advanced Functional Polymers, Department of Chemistry and School of Molecular Science (BK21), Korea Advanced Institute of Science and Technology, 373-1, Kusung-Dong, Yusung-Gu, Taejon 305-701, Korea Cite this: Macromolecules 2000, 33, 26, 9474–9476Publication Date (Web):December 19, 2000Publication History Received14 September 1999Revised18 September 2000Published online19 December 2000Published inissue 1 December 2000https://doi.org/10.1021/ma991568zCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views567Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (45 KB) Get e-AlertscloseSUBJECTS:Ethers,Monomers,Polymerization,Polymers,Solvents Get e-Alerts
OBVIEDADES NÃO ÓBVIAS DA EDUCAÇÃO SOBRE EDUCAÇÃO, O QUE SE DIZ; NÃO SE DIZ; É PROIBIDO DIZER; É FALSO DIZER. E O QUE SE DEVERIA DIZER (2020)

Educacao e terreno minado, porque e permeado por dinâmicas de poder. Sua importância nao esta nos sussurros sublimes de cunho formativo, na etica obsequiosa da pedagogia, no compromisso com a aprendizagem dos estudantes; isto existe, mas tende a ser da rodem dos enfeites. Sua importância esta em sua politicidade, a capacidade que abriga de se alinhar ou se desalinhar do poder dominante. O exercicio da educacao implica, no educador, uma relacao de poder de cima, tambem hierarquica natural ou usurpada, e, no educando, a contramao da mesma clivagem. No educador, pode ocorrer a pretensao de manietar o educando; neste pode ocorrer uma conquista emancipatoria, ate mesmo a revelia do educador. Leve-se em conta ainda que, tratandose de dinâmicas da vida, sao ambiguas, complexas, em grande parte imprevisiveis, sempre incompletas (DEACON, 2012). Tem aluno que aprende apesar do professor e professor que se desempenha bem apesar do aluno. Tudo isso e possivel, porque a relacao nao e causal mecânica como regra: educacao nao se causa, se media. Mediacao facilmente e um imbroglio politico intenso, porque nenhum controle e linearmente efetivo. Ademais, educacao e industria global pesadissima (VERGER et alii, 2016; WORLD BANK, 2018; KLEES, 2017; NARAYAN; WEIDE, 2018), tambem porque e tipico “investimento”, computado em competitividade e produtividade, movimentando grandes instituicoes, orcamentos cada vez mais significativos, focado em “capital humano” (RINDERMANN, 2018), considerado o “capital” mais decisivo para ocupar a lideranca mundial e turbinar o progresso economico etecnologico (LEE, 2018; DUDERSTADT, 2003). A ideia de considerar o acesso universitario como direito fundamental tambem espraia a corrida por educacao superior exponencialmente mais. A nocao de aprender a aprender ou de formacao permanente implica esticar o processo a vida toda, o que, de um lado, apenas reconhece a dinâmica evolucionaria natural aberta de autoformacao infinda, e, doutro, turbina o “negocio” da educacao. Esta mistura de “negocio” e “direito” envenenasua politicidade.
ChemInform Abstract: SELECTIVE REDUCTIONS. 37. ASYMMETRIC REDUCTION OF PROCHIRAL KETONES WITH B‐(3‐PINANYL)‐9‐BORABICYCLO(3.3.1)NONANE (1985)

Abstract Die aus (+)‐a‐Pinen (I) und dem Boran (II) dargestellte, im Titel genannte Reagens (III) reduziert die prochiralen Ketone (IV) mit hohem Enantiomerenüberschuß zu den entsprechenden optisch aktiven Alkoholen (V).
Anti-noise Power Normalized Cepstral Coefficients for Robust Environmental Sounds Recognition in Real Noisy Conditions (2012)

This paper proposes a new robust environmental sounds recognition technology based on APNCC to improve the accuracy of environmental sounds recognition in real noisy conditions. First, a highly non-stationary noise estimation algorithm is applied for the noise power spectrum estimation. Second, to achieve noise reduction with less residual colored noise, we present a multi-band spectral subtraction. Then, the process of PNCC extraction is combined with the estimated clean environmental sounds to extract APNCC. Finally, using 70 subclasses of 4 classes of clean environmental sounds, the comparison experiments in different environments under different SNRs are constructed based on the combination of SVM classifier and different features, namely APNCC, PNCC and MFCC. The experimental results show that APNCC outperforms other features in average recognition accuracy and noise robustness, especially for conditions of SNRs lower than 30dB.
Development of Robust Starting System Using Sensorless Vector Drive for a Microturbine (2009)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> This paper presents the development of a robust starting system for a microturbine (MT) with a single-shaft structure. Because the operating speed for the ignition and motoring of an MT is close to several tens of thousands of revolutions per minute, stable high-speed operation of the high-speed motor-generator (HSMG) is a critical issue in realizing a starting system for a single shaft. A sensorless vector inverter was developed for this high-speed operation. To successfully start an MT with the developed starter in practice, two new starting algorithms were proposed. One is a constant power output control algorithm that can maintain a perfect motoring schedule with significantly deteriorated performance of the input battery power in a vehicle under an extremely low temperature and severe engine drag. The other is a new reliable ignition verification logic that uses the inverter output current when the exhausted gas temperature sensor does not work properly. Since the two proposed algorithms are derived from the torque and <formula formulatype="inline"><tex Notation="TeX">$q$</tex></formula>-axis current formulas for the vector drive, no additional hardware is required to apply them to an existing MT. In this paper, a single-shaft MT with a 10-kW inverter, 6-kW booster converter, and 25-kW HSMG was developed, and the proposed algorithms were applied to motoring. To verify the performance of the proposed algorithms, experiments were carried out under variable conditions, such as extremely low temperature <formula formulatype="inline"><tex Notation="TeX">$(-32\ ^{\circ}\hbox{C})$ </tex></formula> and room temperature. The MT has used in a military truck for supplying electrical power and bleeding air. </para>
Modelling and Simulation of Standardised Control Functions from Building Automation (2017)

Despite the accepted fact that control logic deployed in future and existing buildings through building automation systems constitutes a key factor for increasing their energy efficiency, the support for modelling and simulation of these in current state-of-the-art simulation tools and libraries is rather limited.In particular a gap exists for modelling and simulation of standardised control functions.In this work we present an approach for modelling standardised control logic using Modelica.We evaluated the interoperability of the modelling approach by simulating a test case of an automation solution controlling the sunshade of a room and by reimplementing a state-based control for an air handling unit reusing models from two Annex60 compliant libraries.
Improving Accuracy and Efficiency with Concurrent Use of Artificial Intelligence for Digital Breast Tomosynthesis (2019)

The concurrent use of an accurate DBT AI system was found to improve cancer detection efficacy in a reader study that demonstrated increases in AUC, sensitivity, and specificity and a reduction in recall rate and reading time.© RSNA, 2019See also the commentary by Hsu and Hoyt in this issue.
Fast 2 x 2 Mach-Zehnder optical space switches using InGaAsP-InP multiquantum-well structures (1995)

We report fast 2/spl times/2 Mach-Zehnder optical space switches by using quantum confined Stark effect in InGaAsP-InP multiquantum-well structures that are ultracompact, require low voltages, and employ a simple RF drive with RC time-constant limited lumped electrodes. Cut-off frequencies in excess of 10 GHz are observed suitable for a variety of fast optical switching applications.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
초등학생의 공공도서관 도서 대출을 통해 살펴본 독서 경향 연구 (2019)

본 연구는 초등학생의 도서 대출 실태 및 독서 경향을 살펴보기 위하여 공공도서관 빅데이터 플랫폼 ‘도서관 정보나루’의 도서 대출 데이터를 분석하였다. 연구대상은 2008년부터 2017년까지 전국 공공도서관의 8~13세 아동의 최다 대출도서 200권이 다. 위 데이터를 활용하여 대출연도와 성별을 기준으로 KDC, 출판연도, 저자, 번역 여부에 따른 대출건수와...