gebhart/patrepeval huggingface dataset:
Frequency and Location of Extracapsular Extensionand Positive Surgical Margins in Radical Prostatectomy Specimens (1992)

Positive surgical margins have been reported with disturbing frequency in radical prostatectomy specimens and may portend an increased risk of eventual treatment failure. We determined the location of any cancer, extracapsular extension and positive surgical margins in 144 consecutive step-sectioned radical prostatectomy specimens. Of the 46 stage A cancer patients 98% had residual cancer in the prostate after transurethral resection and in 76% cancer was found posteriorly in the gland. Extracapsular extension was identified in 10 patients (22%): anteriorly in 5, posterolaterally in 5 and on the most apical transverse section in 4. Positive margins were found in 10 patients (22%) and half of these occurred posterolaterally. Of the 98 stage B cancer patients tumor was located posteriorly in 97%. Extracapsular extension was found in 62 patients (63%) and in 87% of these it was located posterolaterally. Positive margins were found in 23%, most commonly in the posterolateral and rectal areas (57% and 26%, respectively), and in more than half of these the positive margin resulted from incision into the capsule. In 18 of the 144 patients (13%) a single positive surgical margin was the only pathological indicator of treatment failure and half of these occurred in the area of the neurovascular bundle. Some of these patients with extraprostatic tumor might have been cured if wide excision of the neurovascular bundle had been performed. Overemphasis on preservation of potency during radical prostatectomy may leave some patients with persistent local disease.
Metastability behavior of mismatched CMOS flip-flops using state diagram analysis (2002)

The effect on the metastability of the mismatch of FET parameters and load capacitances in a CMOS latch/flip-flop is analyzed. A novel method using state diagrams is proposed. On the state diagrams obtained by transient analysis of the latch, a straight line can be approximately drawn that defines two semiplanes, which precisely determine the latch final state. SPICE simulation results are shown for matched/mismatched flip-flops.
ChemInform Abstract: Highly exo‐Diastereoselective Diels‐Alder Reactions of (2S)‐N‐Benzoyl‐ 2‐tert‐butyl‐4‐methylene‐1,3‐oxazolidin‐5‐one. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
1,3,4,5-Tetrahydrobenz[cd]indoles and related compounds. Part II. (1972)

The preparation of 3,4-dihydro-1 -(p-tolylsulphonyl)benz[cd]indol-5(1H)-one (2) and its conversion to a wide variety of 5-substituted tetrahydrobenz[cd]indoles are described, thus demonstrating the value of the N-tosyl protecting group in indole chemistry. Several reactions were also possible with the corresponding 1-acetyl derivative (3).
Factor IX Metal Ion-Dependent Antigen Assays for Measurement of Warfarin Effect (1987)

Factor IX metal ion-dependent antigen was assayed using monoclonal antibodies in 521 samples obtained after prothrombin time testing in patients treated with warfarin. Factor IX metal ion-dependent antigen was less than measured Factor IX clotting activity and less than total Factor IX antigen adsorbable to aluminium hydroxide, suggesting that the metal ion-dependent antigen assay measures a subpopulation of circulating Factor IX in patients treated with oral anticoagulants. There was a graded decrease of Factor IX metal ion-dependent antigen as prothrombin times increased in patient samples. In two hospitals, the median prothrombin times and Factor IX antigen levels were 19 and 20 seconds and 0.10 and 0.11 U/mL (kU/L), respectively. This study shows that immunoassays measure the biologic effect of warfarin and provide information that may supplement the prothrombin time test for patient monitoring. Factor IX metal ion-dependent antigen assays may be useful in efforts to standardize laboratory tests for warfarin effect.
Human nonmuscle myosin heavy chain mRNA: generation of diversity through alternative polyadenylylation. (1990)

Myosin is a ubiquitous eukaryotic contractile protein that generates the force responsible for such diverse cellular movements as muscle contraction and cytokinesis. Although there have been numerous studies of sarcomeric myosin heavy chain (MHC) genes, no molecular clones have been reported that encode mammalian nonmuscle MHC. This study presents the molecular genetic characterization of a human nonmuscle MHC that is expressed in fibroblasts, endothelial cells, and macrophages. Human nonmuscle MHC amino acids are weakly homologous (33%) to sarcomeric MHC but are approximately 72% identical to smooth muscle MHC. In contrast to vertebrate sarcomeric MHCs, which generate diversity through the expression of members of a multigene family, an alternative polyadenylylation site is used in the nonmuscle MHC gene to generate multiple transcripts that encode the same protein. We have mapped this gene to chromosome 22. It is thus unlinked to either of the sarcomeric MHC gene clusters on human chromosomes 14 and 17.
Death Certification and the Coroner (2006)

This chapter contains section titled: Which deaths need referral to the coroner Cause of death Cremation forms Exercises Answers References
Thrombolysis in cerebral ischemia. A review of clinical and experimental data. (1993)

Thrombolytic therapy has been proposed in the treatment of cerebrovascular occlusive disease. Early clinical experiences with Urokinase and Streptokinase raised concern about the risk of hemorrhagic complications. More recently, tissue plasminogen activator (tPA) has been evaluated experimentally with promising results. Its clinical utilization has been recently initiated. A review of experimental and clinical data on thrombolysis in cerebral ischemia is presented. TPA treatment produced recanalization and clinical improvement in several patients. The rate of intracranial hemorrhagic complications is similar to the incidence of spontaneous hemorrhagic conversion of ischemic infarction. Nevertheless, large placebo-controlled clinical trials are necessary to further define the efficacy and the optimal modality of administration of tPA in thromboembolic stroke.
Identifying cellular genes crucial for the reactivation of Kaposi's sarcoma-associated herpesvirus latency (2006)

Kaposi's sarcoma-associated herpesvirus (KSHV) is the latest addition to the long list of human herpesviruses. Reactivation of latent herpesvirus infections is still a mystery. It was demonstrated recently that the phorbol ester TPA was efficient in inducing a reactivation of KSHV infection in the S phase of the cell cycle. In the present study, flow cytometry-sorted, TPA-induced, KSHV-infected haematopoietic cells (BCBL-1) were used to analyse the expression profiles of cancer-related cellular genes in the S phase of the cell cycle compared with the G0/1 phase by using microarrays. Overall, the S phase of the cell cycle seems to provide KSHV with an apt environment for a productive lytic cycle of infection. The apt conditions include cellular signalling that promotes survivability, DNA replication and lipid metabolism, while blocking cell-cycle progression to M phase. Some of the important genes that were overexpressed during the S phase of the cell cycle compared with the G0/1 phase of TPA-induced BCBL-1 cells are v-myb myeloblastosis (MYBL2), protein kinase-membrane associated tyrosine/threonine 1 (PKMYT1), ribonucleotide reductase M1 polypeptide (RRM1) and peroxisome proliferator-activated receptors delta (PPARD). Inhibition of PKMYT1 expression by the use of specific short interfering RNAs significantly lowered the TPA-induced KSHV lytic cycle of infection. The significance of these and other genes in the reactivation of KSHV is discussed in the following report. Taken together, a flow cytometry-microarray-based method to study the cellular conditions critical for the reactivation of KSHV infection is reported here for the first time.
Interleukin 1-induced phosphorylation of MAD3, the major inhibitor of nuclear factor <i>κ</i>B of HeLa cells. Interference in signalling by the proteinase inhibitors 2,4-dichloroisocoumarin and tosylphenylalanyl chloromethylketone (1995)

The regulation of the inhibitor of nuclear factor kappa B (I kappa B) by interleukin 1 (IL1) was investigated in HeLa cells. Two forms of I kappa B were resolved by ion-exchange chromatography. The major form (75%) was identified as MAD3 by specific antisera. IL1 generated rapidly (6 min) an electrophoretically retarded form of MAD3 that was stable in acid and was converted into the unmodified form by phosphatase 2A. It thus corresponded to a phosphorylation of the protein on serine or threonine. IL1 also caused the disappearance of MAD3 from the cells, which was complete 15 min after stimulation and coincided with a 46% reduction of cellular I kappa B activity. Newly-synthesized MAD3 accumulated to pre-stimulation levels between 60 and 90 min after stimulation and this coincided with the down-regulation of the phosphorylating activity. The serine proteinase inhibitors 3,4-dichloroisocoumarin (DCI) and tosylphenylalanyl chloromethylketone (TPCK) prevented phosphorylation and disappearance of MAD3. At the same concentrations (10-100 microM), they also increased basal phosphorylation of the small heat shock protein (hsp27) and prevented the IL1- and phorbol 12-myristate 13-acetate-induced increases of its phosphorylation. The inhibitors were thus interfering with protein kinases when blocking degradation of MAD3. Recombinant MAD3 phosphorylated in vitro by protein kinase C was not electrophoretically retarded, suggesting that MAD3 was phosphorylated by another kinase in IL1-stimulated cells. Our results suggest that the IL1-induced phosphorylation of MAD3 on serine or threonine leads to its degradation. DCI and TPCK blocked phosphorylation mechanisms and it could not be concluded that serine proteinases were involved in the breakdown of MAD3.
A Log Based Approach to Make Digital Forensics Easier on Cloud Computing (2013)

Cloud computing is getting more and more attention from the information and communication technologies industry recently. Almost all the leading companies of the information area show their interesting and efforts on cloud computing and release services about cloud computing in succession. But if want to make it go further, we should pay more effort on security issues. Especially, the Internet environment now has become more and more unsecure. With the popularization of computers and intelligent devices, the number of crime on them has increased rapidly in last decades, and will be quicker on the cloud computing environment in future. No wall is wall in the world. We should enhance the cloud computing not only at the aspect of precaution, but also at the aspect of dealing with the security events to defend it from crime activities. In this paper, I propose a approach which using logs model to building a forensic-friendly system. Using this model we can quickly gather information from cloud computing for some kinds of forensic purpose. And this will decrease the complexity of those kinds of forensics.
Recent Photocatalytic Applications for Air Purification in Belgium (2014)

Photocatalytic concrete constitutes a promising technique to reduce a number of air contaminants such as NOx and VOC’s, especially at sites with a high level of pollution: highly trafficked canyon streets, road tunnels, the urban environment, etc. Ideally, the photocatalyst, titanium dioxide, is introduced in the top layer of the concrete pavement for best results. In addition, the combination of TiO2 with cement-based products offers some synergistic advantages, as the reaction products can be adsorbed at the surface and subsequently be washed away by rain. A first application has been studied by the Belgian Road Research Center (BRRC) on the side roads of a main entrance axis in Antwerp with the installation of 10.000 m² of photocatalytic concrete paving blocks. For now however, the translation of laboratory testing towards results in situ remains critical of demonstrating the effectiveness in large scale applications. Moreover, the durability of the air cleaning characteristic with time remains challenging for application in concrete roads. From this perspective, several new trial applications have been initiated in Belgium in recent years to assess the “real life” behavior, including a field site set up in the Leopold II tunnel of Brussels and the construction of new photocatalytic pavements on industrial zones in the cities of Wijnegem and Lier (province of Antwerp). This paper first gives a short overview of the photocatalytic principle applied in concrete, to continue with some main results of the laboratory research recognizing the important parameters that come into play. In addition, some of the methods and results, obtained for the existing application in Antwerp (2005) and during the implementation of the new realizations in Wijnegem and Lier (2010–2012) and in Brussels (2011–2013), will be presented.
Pentaorgano[60]fullerene R5C60−. A Water Soluble Hydrocarbon Anion (2000)

Abstract A new class of hydrocarbon anions, pentaaryl- and pentamethylfullerene anions R5C60− (R = Ph, 4-BuC6H4, 4-PhC6H4, Me) was found to be stable and soluble in water. Atomic force microscopic observation and dynamic light scattering measurements indicated that the potassium salt Ph5C60K in water forms spherical aggregates with an averaged radius of about 17 nm.
DESIGN AND SIZING OF SCREW FEEDERS (2001)

This paper is concerned with the design criteria of screw feeders: a non proper design and selection of this device, which is present in large part of industrial processes, could mean poor performances, excessive power, severe wear of plant and degradation of the conveyed material. In the past the performance of screw feeders has been based either on a semi-empirical approach (C.E.M.A.- like procedure) or on experimental studies using dynamic similarity to predict the performance of geometrically similar screws. Both these procedures are somewhat limiting and are quite unuseful in industrial practice. A general procedure has been developed to predict the performance of screw feeders of any specific geometry: contrary to the approach of all the formulae present in literature which give the power at operating speed, industrial experience however clearly shows that the most important phenomenon as regards sizing the power is that of starting torque.
Gene silencing in plants (2007)

Here, the role of small RNAs is described in (i) cytoplasmic viral RNA silencing; (ii) cellular mRNA silencing via miPHK production. The role of cellular factors such as Dicers, Argonautes, RNA-dependent RNA-polymerase, RNA-polymerase IV and pectin methylesterase are discussed in details. Moreover, silencing suppression by viral proteins/RNAs and silencing as an approach of biotechnology are reviewed.
Numerical analysis of finite frequency selective surfaces with rectangular patches of various aspect ratios (1991)

The finite frequency selective surface studied consists of a two-dimensional array, finite in one dimension and infinite in the other, of perfectly electrically conducting plates in free space. The analysis uses a Green's function formulation in the spectral domain, and the resulting equation is solved using the method of moments. Techniques are demonstrated for increasing the speed of the numerical computation so that the problem can be solved on a VAX 11-780 in a reasonable amount of time. Two types of basis functions, one subsectional and the other complete domain, are used to represent the currents on the patches. Both yield similar results and both are suitable for use in this problem. Techniques are demonstrated for approximating the tails of the infinite integrations which allow a more accurate solution than truncation. Results for scattered power density and patch currents illustrate the edge effect and incident angle dependencies. Results showing 3 dB bandwidth, resonance peak versus frequency, and scattered power versus frequency are plotted for patches with aspect ratios varying from 0.1 to 1.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Correction for variations in MRI scanner sensitivity in brain studies with histogram matching (1998)

Quantitative comparisons of abnormalities in MRI scans between patients or within patients serially are affected by variations in MR scanner performance. A histogram matching method is proposed to correct for variation in scanner sensitivity. It is demonstrated that this histogram matching method reduced the variation in white matter intensities across normal subjects from 7.5 to 2.5% and provided a method to remove the threshold dependency in lesion volume measurement with global thresholding in patients with multiple sclerosis (MS). The effectiveness of the method was compared with three other possible correction schemes. The histogram matching method was shown to be 2 to 5 times better.
Packet Routing in Dynamically Changing Networks: A Reinforcement Learning Approach (1993)

This paper describes the Q-routing algorithm for packet routing, in which a reinforcement learning module is embedded into each node of a switching network. Only local communication is used by each node to keep accurate statistics on which routing decisions lead to minimal delivery times. In simple experiments involving a 36-node, irregularly connected network, Q-routing proves superior to a nonadaptive algorithm based on precomputed shortest paths and is able to route efficiently even when critical aspects of the simulation, such as the network load, are allowed to vary dynamically. The paper concludes with a discussion of the tradeoff between discovering shortcuts and maintaining stable policies. 1 INTRODUCTION The field of reinforcement learning has grown dramatically over the past several years, but with the exception of backgammon [8, 2], has had few successful applications to large-scale, practical tasks. This paper demonstrates that the practical task of routing packets through...
Secukinumab in Plaque Psoriasis — Results of Two Phase 3 Trials (2014)

Secukinumab was effective for psoriasis in two randomized trials, validating interleukin-17A as a therapeutic target. (Funded by Novartis Pharmaceuticals; ERASURE and FIXTURE ClinicalTrials.gov numbers, NCT01365455 and NCT01358578, respectively.).
Growth During Childhood and Final Height in Type 1 Diabetes (1994)

The growth of 184 children with Type 1 diabetes was analysed using data collected prospectively in the Oxford district between 1969 and 1992. The overall mean height standard deviation score (Ht SDS +/- SD) at diagnosis was 0.35 +/- 1.05 which was significantly greater than the national standard of Tanner (1966). However, there is evidence of a secular trend in the heights of Oxford children over the last 20 years when compared with Tanner. When data from children with diabetes were compared with local controls, it was only the children aged 5-10 years at diagnosis who were taller (Ht SDS +/- SD, 0.58 +/- 1.14, versus 0.31 +/- 0.90, n = 73, p < 0.05). Those diagnosed under the age of 5 years (n = 37) were shorter (Ht SDS 0.12 +/- 0.93) and those diagnosed aged more than 10 years (n = 74) were similar in size (Ht SDS 0.22 +/- 0.98) to controls. These differences could not be explained by social class. Loss of height occurred between diagnosis and puberty, particularly in those diagnosed between the ages of 5 and 10 years. The pubertal growth spurt was blunted in all groups but this abnormality was more profound in the girls (mean peak height velocity SDS -1.09 +/- 1.02, p < 0.0005) than in the boys (mean peak height volocity SDS -0.5 +/- 1.14, p < 0.025). The mean final height SDS was -0.74 +/- 0.96 in those diagnosed < 5 years, 0.00 +/- 1.26 in those diagnosed between the ages of 5 and 10 years and 0.09 +/- 1.10 in those aged more than 10 years at diagnosis.(ABSTRACT TRUNCATED AT 250 WORDS)
APPLICATION MIGRATION EFFORT IN THE CLOUD (2015)

Over the last years, the utilization of cloud resources has been steadily rising and an increasing number of enterprises are moving applications to the cloud. A leading trend is the adoption of Platform as a Service to support rapid application deployment. By providing a managed environment, cloud platforms take away a lot of complex configuration effort required to build scalable applications. However, application migrations to and between clouds cost development effort and open up new risks of vendor lock-in. This is problematic because frequent migrations may be necessary in the dynamic and fast changing cloud market. So far, the effort of application migration in PaaS environments and typical issues experienced in this task are hardly understood. To improve this situation, we present a cloud-to-cloud migration of a real-world application to seven representative cloud platforms. In this case study, we analyze the feasibility of the migrations in terms of portability and the effort of the migrations. We present a Docker-based deployment system that provides the ability of isolated and reproducible measurements of deployments to platform vendors, thus enabling the comparison of platforms for a particular application. Using this system, the study identifies key problems during migrations and quantifies these differences by distinctive metrics.
Mechanism of Nucleate Boiling Heat Transfer Enhancement From Microporous Surfaces in Saturated FC-72 (2002)

Abstract The present study is an experimental investigation of the nucleate pool boiling heat transfer enhancement mechanism of microporous surfaces immersed in saturated FC-72. Measurements of bubble size, frequency, and vapor flow rate from a plain and microporous coated 390 μm diameter platinum wire using the consecutive-photo method were taken to determine the effects of the coating on the convective and latent heat transfer mechanisms. Results of the study showed that the microporous coating augments nucleate boiling performance through increased latent heat transfer in the low heat flux region and through increased convection heat transfer in the high heat flux region. The critical heat flux for the microporous coated surface is significantly enhanced over the plain surface due to decreased latent heat transfer (decreased vapor generation rate) and/or increased hydrodynamic stability from increased vapor inertia; both of which are a direct result of increased nucleation site density.
X-ray scalpel—a new device for targeted x-ray brachytherapy and stereotactic radiosurgery (2007)

The basic design and performance of a novel x-ray scalpel device for interstitial radiosurgery are reported. The x-ray scalpel is comprised of a capillary optics collimator conjugated with a high brilliance microfocus x-ray tube and a thin hollow needle (tip) attached to the collimator. The device is capable of producing a high dose rate (about 140 Gy min(-1) in water-like absorber at the exit window), 0.7 mm diameter, quasi-parallel beam that can be delivered to a targeted site by a minimally invasive procedure. Contrary to insertable x-ray tubes or radionuclides used in brachytherapy and complying with the 1/r(2) radiation attenuation law, the dose rate for a quasi-parallel beam decreases with distance as mu exp(-mu r), where mu is the energy-dependent linear attenuation coefficient in the exposed medium. Moreover, the shape, energy and the dose attenuation curve of the x-ray beam can be adjusted. Two versions of the x-ray scalpel device (5.4 keV and 20.2 keV) are described. We present results from our first test of the x-ray scalpel as a controllable source of focal radiation for producing radiation necrosis in rat brain tissue. Irradiation was transdurally delivered to the rat cerebral cortex for 10 min at a dose rate of 20 Gy min(-1).