gebhart/patrepeval huggingface dataset:
State of the art paper Biochemistry of adipose tissue: an endocrine organ (2013)

Adipose tissue is no longer considered to be an inert tissue that stores fat. This tissue is capable of expanding to accommodate increased lipids through hypertrophy of existing adipocytes and by initiating differentiation of pre-adipocytes. Adipose tissue metabolism exerts an impact on whole-body metabolism. As an endocrine organ, adipose tissue is responsible for the synthesis and secretion of several hormones. These are active in a range of processes, such as control of nutritional intake (leptin, angiotensin), control of sensitivity to insulin and inflammatory process mediators (tumor necrosis factor α (TNF-α), interleukin-6 (IL-6), resistin, visfatin, adiponectin, among others) and pathways (plasminogen activator inhibitor 1 (PAI-1) and acylation stimulating protein (ASP) for example). This paper reviews some of the biochemical and metabolic aspects of adipose tissue and its relationship to inflammatory disease and insulin resistance.
Limited fibrosis accompanies triple-negative breast cancer metastasis in multiple model systems and is not a preventive target (2018)

The lysophosphatidic acid receptor 1 (LPAR1) is mechanistically implicated in both tumor metastasis and tissue fibrosis. Previously, metastasis was increased when fulminant fibrosis was first induced in mice, suggesting a direct connection between these processes. The current report examined the extent of metastasis-induced fibrosis in breast cancer model systems, and tested the metastasis preventive efficacy and fibrosis attenuation of antagonists for LPAR1 and Idiopathic Pulmonary Fibrosis (IPF) in breast and ovarian cancer models. Staining analysis demonstrated only focal, low-moderate levels of fibrosis in lungs from eleven metastasis model systems. Two orally available LPAR1 antagonists, SAR100842 and EPGN9878, significantly inhibited breast cancer motility to LPA <i>in vitro</i>. Both compounds were negative for metastasis prevention and failed to reduce fibrosis in the experimental MDA-MB-231T and spontaneous murine 4T1 <i>in vivo</i> breast cancer metastasis models. SAR100842 demonstrated only occasional reductions in invasive metastases in the SKOV3 and OVCAR5 ovarian cancer experimental metastasis models. Two approved drugs for IPF, nintedanib and pirfenidone, were investigated. Both were ineffective at preventing MDA-MB-231T metastasis, with no attenuation of fibrosis. In summary, metastasis-induced fibrosis is only a minor component of metastasis in untreated progressive breast cancer. LPAR1 antagonists, despite <i>in vitro</i> evidence of specificity and efficacy, were ineffective <i>in vivo</i> as oral agents, as were approved IPF drugs. The data argue against LPAR1 and fibrosis as monotherapy targets for metastasis prevention in triple-negative breast cancer and ovarian cancer.
On extended Alamouti schemes for space-time coding (2003)

The Alamouti space-time code for transmission diversity is extended recursively to 2/sup n/ /spl times/ 2/sup n/ antenna elements as well as to unsymmetrical arrays of size m /spl times/ n. The proposed schemes exhibit two significant advantages: they allow for higher diversity (of degree 2/sup n/ for the symmetrical case) and at the same time can be implemented as zero-forcing or MMSE type at low complexity avoiding any matrix inversion due to the structure in the transmission matrices as well as low complexity ML.
Deep Instance Segmentation of Teeth in Panoramic X-Ray Images (2018)

In dentistry, radiological examinations help specialists by showing structure of the tooth bones with the goal of screening embedded teeth, bone abnormalities, cysts, tumors, infections, fractures, problems in the temporomandibular regions, just to cite a few. Sometimes, relying solely in the specialist's opinion can bring differences in the diagnoses, which can ultimately hinder the treatment. Although tools for complete automatic diagnosis are no yet expected, image pattern recognition has evolved towards decision support, mainly starting with the detection of teeth and their components in X-ray images. Tooth detection has been object of research during at least the last two decades, mainly relying in threshold and region-based methods. Following a different direction, this paper proposes to explore a deep learning method for instance segmentation of the teeth. To the best of our knowledge, it is the first system that detects and segment each tooth in panoramic X-ray images. It is noteworthy that this image type is the most challenging one to isolate teeth, since it shows other parts of patient's body (e.g., chin, spine and jaws). We propose a segmentation system based on mask region-based convolutional neural network to accomplish an instance segmentation. Performance was thoroughly assessed from a 1500 challenging image data set, with high variation and containing 10 categories of different types of buccal image. By training the proposed system with only 193 images of mouth containing 32 teeth in average, using transfer learning strategies, we achieved 98% of accuracy, 88% of F1-score, 94% of precision, 84% of recall and 99% of specificity over 1224 unseen images, results very superior than other 10 unsupervised methods.
Plasma enhanced metalorganic chemical vapor deposition of amorphous aluminum nitride (2001)

Plasma enhanced deposition of amorphous aluminum nitride (AlN) using trimethylaluminum, hydrogen, and nitrogen was performed in a capacitively coupled plasma system. Temperature was varied from 350 to 550 °C, and pressure dependence of the film structure was investigated. Films were characterized by Fourier transform infrared, Rutherford backscattering (RBS), ellipsometry, and x-ray diffraction (XRD). The films are amorphous in nature, as indicated by XRD. Variations in the refractive index were observed in ellipsometric measurements, which is explained by the incorporation of carbon in the films, and confirmed by RBS. Capacitance–voltage, conductance–voltage (G–V), and current–voltage measurements were performed to reveal bulk and interface electrical properties. The electrical properties showed marked dependence on processing conditions of the AlN films. Clear peaks as observed in the G–V characteristics indicated that the losses are predominantly due to interface states. The interface state density ranged between 1010 and 1011 eV−1 cm−2. Annealing in hydrogen resulted in lowering of interface state density values.
Telmisartan Treatment Decreases Visceral Fat Accumulation and Improves Serum Levels of Adiponectin and Vascular Inflammation Markers in Japanese Hypertensive Patients (2007)

Hypertension contributes to the occurrence and progression of cardiovascular diseases. The angiotensin II type 1 receptor blocker telmisartan is reported to activate the peroxisome proliferator-activated receptor gamma and improve insulin sensitivity. We investigated the effects of telmisartan treatment on visceral fat, serum adiponectin and vascular inflammation markers in Japanese hypertensive patients. This was an open-label, non-controlled study. Twenty-eight essential hypertensive patients (22 men and 6 women; age 60.6+/-1.9 years; body mass index [BMI] 25.5+/-0.6 kg/m(2)) participated. Fat area was assessed with computerized tomography. All the subjects were started on telmisartan 40 mg/day, which was increased to 80 mg/day to achieve the blood pressure target of less than 130/80 mmHg. We assessed the visceral and subcutaneous fat areas, serum adiponectin levels, and vascular inflammation markers at baseline and 24 weeks of telmisartan treatment. There were significant reductions in visceral fat area (from 103.1+/-7.9 to 93.3+/-8.4 cm(2), p<0.01) and pulse wave velocity (from 1,706+/-52 to 1,587+/-51 cm/s, p<0.01) at 24 weeks. In contrast, significant increases in serum high-density lipoprotein cholesterol (from 5.06+/-0.15 to 5.32+/-0.13 mmol/L, p<0.05) and adiponectin levels (from 8.27+/-0.76 to 9.13+/-0.81 microg/mL, p<0.05) were observed. Also, there were reductions in the interleukin-6 level (from 2.26+/-0.27 to 1.60+/-0.14 pg/mL, p<0.01). We also conducted these investigations in male subjects alone and similar findings were obtained for all of these parameters. In conclusion, telmisartan treatment was associated with an improvement of vascular inflammation, reductions in visceral fat and increases in serum adiponectin.
Molecular cloning and expression of a new putative inositol 1,4,5-trisphosphate 3-kinase isoenzyme (1991)

A human hippocampus cDNA library in lambda ZAP II was screened by hybridization with a rat brain inositol 1,4,5-trisphosphate (InsP3) 3-kinase cDNA. Two clones (hh6 and hh3) were isolated and sequenced. The insert of clone hh6 was shown to correspond to the 3' end of the coding sequence of 50,000-Mr InsP3 3-kinase (referred to as 3-kinase-A). Sequencing of the clone hh3 insert yielded an open reading frame encoding a 472-amino acid protein with a calculated Mr of 53,451 (referred to as 3-kinase-B). The C-terminal part of 3-kinase-B (residues 187-462) was 68% identical with 3-kinase-A in amino acid sequence. The cDNA of clone hh3 was rescued as a Bluescript plasmid and expressed in Escherichia coli as a beta-galactosidase fusion product. It showed InsP3 3-kinase activity that was stimulated in the presence of Ca2+/calmodulin (more than 7-fold in a crude bacterial lysate from expressed plasmid). Regeneration of InsP3 3-kinase activity after SDS/PAGE identified a major polypeptide (Mr 60,000-65,000). The Km for InsP3 of expressed 3-kinase-B was 1.6 microM. These data provide molecular evidence for the existence of InsP3 3-kinase isoenzymes.
Polyurethane based on hydroxyl‐terminated polybutadienes (1971)

Abstract Butadiene has been found to homopolymerise and copolymerise with other reactive vinyl monomers to yield unique liquid polymers which are terminated with reactive allylic hydroxyl groups. Through the use of an isocyanate cure reaction they offer a route to liquid castable general purpose elastomers, capable of reinforcement with various fillers and extension with a wide variety of low cost process oils.
Integrated Genome-Wide DNA Copy Number and Expression Analysis Identifies Distinct Mechanisms of Primary Chemoresistance in Ovarian Carcinomas (2009)

We have identified two distinct mechanisms of primary treatment failure in serous ovarian cancer, involving CCNE1 amplification and enhanced extracellular matrix deposition. CCNE1 copy number is validated as a dominant marker of patient outcome in ovarian cancer.
Parallel Antioxidant and Antiexcitotoxic Therapy Improves Outcome After Incomplete Global Cerebral Ischemia in Dogs (1997)

Pretreatment and posttreatment with GPI ameliorated postischemic metabolic failure, suggesting that NMDA-mediated mechanisms are more important in global cerebral ischemia complicated by dense, acidosis than early studies indicated. Combined treatment with GPI and DFO improved cerebral blood flow during reperfusion and one indicator of energy recovery. These data support the hypothesis that parallel therapy aimed at antioxidant and antiexcitotoxic mechanisms of ischemic brain injury augment recovery compared with the individual agents.
Detection of organophosphorus compound based on a sol–gel silica planar waveguide doped with a green fluorescent protein and an organophosphorus hydrolase (2011)

In this letter, the authors report the real-time detection of an organophosphorus compound using a sol–gel silica planar waveguide doped with a green fluorescent protein and an organophosphorus hydrolase on a yeast-cell surface display. The waveguide was pumped at 488 nm, and it emitted green fluorescence at the far field. The green fluorescent light at 550 nm changed by 50% from the original power 1 min after application of the organophosphorus compound. The results enable the real-time detection of sarin and other biochemicals by using an in-line fiber sensor network.
CAM and Cell Fate Targeting: Molecular and Energetic Insights into Cell Growth and Differentiation (2005)

Evidence-based medicine is switching from the analysis of single diseases at a time toward an integrated assessment of a diseased person. Complementary and alternative medicine (CAM) offers multiple holistic approaches, including osteopathy, homeopathy, chiropractic, acupuncture, herbal and energy medicine and meditation, all potentially impacting on major human diseases. It is now becoming evident that acupuncture can modify the expression of different endorphin genes and the expression of genes encoding for crucial transcription factors in cellular homeostasis. Extremely low frequency magnetic fields have been found to prime the commitment to a myocardial lineage in mouse embryonic stem cells, suggesting that magnetic energy may direct stem cell differentiation into specific cellular phenotypes without the aid of gene transfer technologies. This finding may pave the way to novel approaches in tissue engineering and regeneration. Different ginseng extracts have been shown to modulate growth and differentiation in pluripotent cells and to exert wound-healing and antitumor effects through opposing activities on the vascular system, prompting the hypothesis that ancient compounds may be the target for new logics in cell therapy. These observations and the subtle entanglement among different CAM systems suggest that CAM modalities may deeply affect both the signaling and transcriptional level of cellular homeostasis. Such a perception holds promises for a new era in CAM, prompting reproducible documentation of biological responses to CAM-related strategies and compounds. To this end, functional genomics and proteomics and the comprehension of the cell signaling networks may substantially contribute to the development of a molecular evidence-based CAM.
Single Metal Gate on High-k Gate Stacks for 45nm Low Power CMOS (2006)

We present a low cost, single metal gate/high-k gate stack integration, which provides a very high performing NMOS coupled with a counter-doped PMOS for a 45nm low power (LP) CMOS technology. Inversion T <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ox</sub> (T <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">inv</sub> ) values of 16Å/18Å (NMOS/PMOS) result in gate leakage current densities of 0.1/0.01 A/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> and enable self-heated drive currents of 850/325μA/μm at 1nA/μm off-state leakage and V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">dd</sub> =1V (900/340μA/μm non-self-heated). Additionally, the NMOS drive current of 1550uA/μm (1650μA/μm non-self-heated) at an I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">off</sub> =100nA/μm and V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">dd</sub> =1.2V is the highest reported for a hafnium-based high-k gate stack. The approach is compatible with a dual-gate oxide (DGO) module for I/O devices and allows optimization for performance and power typically only possible in triple gate oxide architectures.
Management of Bone Metastases (2000)

Metastatic bone disease develops as a result of the many interactions between tumor cells and bone cells. This leads to disruption of normal bone metabolism, with the increased osteoclast activity seen in most, if not all, tumor types providing a rational target for treatment. The clinical course of metastatic bone disease in multiple myeloma, breast and prostate cancers is relatively long, with patients experiencing sequential skeletal complications over a period of several years. These include bone pain, fractures, hypercalcemia, and spinal cord compression, all of which may profoundly impair a patient's quality of life. External beam radiotherapy and systemic endocrine and cytotoxic treatments are the mainstay of treatment in advanced cancers. However, it is now clear that the bisphosphonates provide an additional treatment strategy, which reduces both the symptoms and complications of bone involvement. Additionally, new specific molecules such as osteoprotogerin have been developed that are based on our improved understanding of the cellular signaling mechanisms involved in cancer-induced bone disease. These potent molecules are now entering clinical trials. Ongoing research is aimed at trying to define the optimum route, dose, schedule and type of bisphosphonate in metastatic bone disease and its use in the prevention and treatment of osteoporosis in cancer patients. In vitro suggestions of direct anticancer activity and some promising clinical data in early breast cancer have resulted in considerable interest in the possible adjuvant use of bisphosphonates to inhibit the development of bone metastases.
Comparison of a novel in situ polymerase chain reaction (ISPCR) method to other methods for white spot syndrome virus (WSSV) detection in Penaeus vannamei (2005)

Penaeus vannamei were experimentally injected with white spot syndrome virus (WSSV) and tested for WSSV at different times post-injection (p.i.) by 1-step polymerase chain reaction (PCR), 2-step PCR, in situ hybridization (ISH) and in situ polymerase chain reaction (ISPCR) in order to compare sensitivity of the methods. With 1-step PCR, 4 of 15 shrimp tested positive for WSSV at 12 h p.i., and all tested positive by 24 h p.i. With 2-step PCR, 13 out of 15 samples tested positive at 2 h p.i. and all were positive by 4 h p.i. Using in situ hybridization, 1 sample tested positive at 18 h p.i. and all were positive by 36 h p.i. With ISPCR, 1 out of 5 samples was positive at 2 h p.i. and all were positive by 8 h p.i. Two-step PCR showed the highest sensitivity, followed by ISPCR, 1-step PCR and ISH. Although ISPCR revealed WSSV in 9 of 10 P. vannamei that tested positive for WSSV using 2-step PCR, none of the shrimp examined showed clinical signs of WSSV infection or detectable WSSV with 1-step PCR. The major infected organs were muscle and the hepatopancreas.
Assignment Problem in Content Distribution Networks: Unsplittable Hard-capacitated Facility Location (2009)

In a Content Distribution Network (CDN), there are m servers storing the data; each of them has a specific bandwidth. All the requests from a particular client should be assigned to one server, because of the routing protocol used. The goal is to minimize the total cost of these assignments —cost of each is proportional to the distance as well as the request size— while the load on each server is kept below its bandwidth limit. When each server also has a setup cost, this is an unsplittable hard-capacitated facility location problem. As much attention as facility location problems have received, there has been no nontrivial approximation algorithm when we have hard capacities (i.e., there can only be one copy of each facility whose capacity cannot be violated) and demands are unsplittable (i.e., all the demand from a client has to be assigned to a single facility). We observe it is NP-hard to approximate the cost to within any bounded factor. Thus, for an arbitrary constant ∊ > 0, we relax the capacities to a 1 + ∊ factor. For the case where capacities are almost uniform, we give a bicriteria O(log n, 1 + ∊)-approximation algorithm for general metrics and a (1 + ∊, 1 + ∊)-approximation algorithm for tree metrics. A bicriteria (α, β)-approximation algorithm produces a solution of cost at most α times the optimum, while violating the capacities by no more than a β factor. We can get the same guarantee for non-uniform capacities if we allow quasipolynomial running time. In our algorithm, some clients guess the facility they are assigned to, and facilities decide the size of clients they serve. A straight-forward approach results in exponential running time. When costs do not satisfy metricity, we show that a 1.5 violation of capacities is necessary to obtain any approximation. It is worth noting that our results generalize bin packing (zero cost matrix and facility costs equal to one), knapsack (single facility with all costs being zero), minimum makespan scheduling for related machines (all costs being zero) and some facility location problems.
Westdeutsche Bauwirtschaft: Auslaufen des Investitionsbooms (1992)

Die Bauunternehmen in den alten Bundesländern haben ihre ursprünglichen Pläne für 1992 zwar auch nach unten revidiert. Sie investieren mit 6, 85 Mrd. DM aber dennoch um 7% mehr als 1991. Nach den Ergebnissen des ifo Investitionstests vom September/Oktober 1992 plant die Bauwirtschaft für nächstes Jahr höchstens um 2 bis 3% höhere Investitionen. Kapazitätserweiterungen sind kaum noch vorgesehen.
Poly(<i>N</i>-isopropylacrylamide-<i>c</i><i>o</i>-propylacrylic acid) Copolymers That Respond Sharply to Temperature and pH (2006)

Temperature- and pH-sensitive random copolymers of N-isopropylacrylamide (NIPAAm) and propylacrylic acid (PAA) were prepared using the reversible addition fragmentation chain transfer (RAFT) polymerization method. The lower critical solution temperatures (LCSTs) (or phase separation temperatures) of the NIPAAm-co-PAA copolymer solutions were measured by the cloud-point method. At slightly acidic conditions, the LCST decreased with increase in PAA content, which suggests that the hydrophobic propyl group of PAA has a greater influence on the LCST than the polar carboxylic acid group at those conditions. An increase of pH led to a significant increase in LCST of the copolymers due to the ionization of the -COOH group. The LCSTs were studied as a function of copolymer composition over the pH range from 5.0 to 7.0. Because the pK(a) of the polymers can be tuned to fall close to neutral pH, these polymer compositions can be designed to have phase transitions triggered near physiological pH or at slightly acidic pH values that fall within acidic gradients found in biology. The NIPAAm-co-PAA copolymers thus display tunable properties that could make them useful in a variety of molecular switching and drug delivery applications where responses to small pH changes are relevant.
Improvement in MOS reliability by oxidation in ozone (2002)

Using clean ozone in a new load-locked oxidation system, we made thin gate oxides with improved charge to breakdown characteristics (Q/sub bd/) and low surface state sensitise (D/sub it/).< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Evaluation of an Alcohol-Based Surgical Hand Disinfectant Containing a Synergistic Combination of Farnesol and Benzethonium Chloride for Immediate and Persistent Activity Against Resident Hand Flora of Volunteers and With a Novel In Vitro Pig Skin Model (2007)

The ZBF disinfectant we evaluated met the FDA-TFM criteria for surgical hand disinfectants. The immediate and persistent efficacy of the surgical hand disinfectants evaluated with the novel pig skin model described in this study shows good agreement with the results obtained in vivo.
Using publish/subscribe middleware for mobile systems (2002)

The range of mobile computing applications comprises location-based services, sensor networks, and ad hoc networking. Middleware for these applications must effectively support the interaction of a priori anonymous entities, support timely decoupled processing, and mediate between potentially millions of mobile clients. These requirements are hard to achieve with traditional client/server middleware systems. We argue that the publish/subscribe paradigm effectively addresses many of the challenges raised by emerging mobile applications. In this paper, we give an overview of the publish/subscribe paradigm, present a detailed analysis of mobile application requirements, and discuss two proven implementations of this paradigm that address these requirements. We thus show that the publish/subscribe paradigm may effectively address most of the challenges raised by emerging mobile applications.