gebhart/patrepeval huggingface dataset:
Human Recombinant Antibody to HSP90: A Natural Partner in Combination Therapy (2005)

Recent years have seen the development of the concept of combination therapy for treating severe fungal sepsis. The advantages of this approach are a potential improvement in patient survival and a reduction in the chance of resistance developing to each of the single agents. The disadvantage is that combining drugs may increase the chance of toxicity. Mycograb is a genetically recombinant antibody against fungal heat shock protein 90 (hsp90) which is poised to become the mainstay of combination therapy. This paper presents data on how hsp90 is important to fungi and what role it might play in human disease with possible interactions with interleukin 6 and nitric oxide. There is discussion of preclinical data demonstrating synergy in vitro between Mycograb and amphotericin B and caspofungin. The progress of Mycograb through a Phase II pharmacokinetic study when used in escalating doses with a liposomal amphotericin B preparation has also been reviewed. The concepts behind a Phase II pivotal study, where Mycograb or a placebo was given in combination with a liposomal amphotericin B drug for five days for the treatment of disseminated candidiasis are discussed.
Oral hypoglycemic effect of <i>Salacia reticulata</i> in the streptozotocin induced diabetic rat (1990)

Abstract The oral hypoglycemic activity of Salacia reticulata extract was evaluated in streptozotocin induced diabetic rats. The diabetic rats were orally administered an aqueous extract of Salacia reticulata and the plasma glucose concentration was determined at regular intervals following administration. The drug was effective as a hypoglycemic agent at all the doses tested (0.5 g/kg, 1.0 g/kg and 5.0 g/kg). The maximum percentage decrease in plasma glucose was observed between 1–5h following administration of the drug.
Intracellular delivery of an anionic antisense oligonucleotide via receptor-mediated endocytosis (2008)

We describe the synthesis and characterization of a 5' conjugate between a 2'-O-Me phosphorothioate antisense oligonucleotide and a bivalent RGD (arginine-glycine-aspartic acid) peptide that is a high-affinity ligand for the alphavbeta3 integrin. We used alphavbeta3-positive melanoma cells transfected with a reporter comprised of the firefly luciferase gene interrupted by an abnormally spliced intron. Intranuclear delivery of a specific antisense oligonucleotide (termed 623) corrects splicing and allows luciferase expression in these cells. The RGD-623 conjugate or a cationic lipid-623 complex produced significant increases in luciferase expression, while 'free' 623 did not. However, the kinetics of luciferase expression was distinct; the RGD-623 conjugate produced a gradual increase followed by a gradual decline, while the cationic lipid-623 complex caused a rapid increase followed by a monotonic decline. The subcellular distribution of the oligonucleotide delivered using cationic lipids included both cytoplasmic vesicles and the nucleus, while the RGD-623 conjugate was primarily found in cytoplasmic vesicles that partially co-localized with a marker for caveolae. Both the cellular uptake and the biological effect of the RGD-623 conjugate were blocked by excess RGD peptide. These observations suggest that the bivalent RGD peptide-oligonucleotide conjugate enters cells via a process of receptor-mediated endocytosis mediated by the alphavbeta3 integrin.
Tunable Mirrorless Lasing in Cholesteric Liquid Crystalline Elastomers (2001)

Tuning the wavelength of a laser emission by mechanical deformation is not as implausible as it may seem. This communication proves that it can be done with cholesteric liquid crystal elastomers. The Figure shows what happens when a beam is focussed on the sample in its relaxed (left) and its stretched form (right).
Algorithmic lattice kirigami: A route to pluripotent materials (2015)

We use a regular arrangement of kirigami elements to demonstrate an inverse design paradigm for folding a flat surface into complex target configurations. We first present a scheme using arrays of disclination defect pairs on the dual to the honeycomb lattice; by arranging these defect pairs properly with respect to each other and choosing an appropriate fold pattern a target stepped surface can be designed. We then present a more general method that specifies a fixed lattice of kirigami cuts to be performed on a flat sheet. This single pluripotent lattice of cuts permits a wide variety of target surfaces to be programmed into the sheet by varying the folding directions.
Arterial Spin-Labeling in Routine Clinical Practice, Part 3: Hyperperfusion Patterns (2008)

Arterial spin-labeled (ASL) perfusion imaging can be implemented successfully into a routine clinical neuroimaging protocol and can accurately demonstrate alterations in brain perfusion. We have observed patterns of focal, regional, and global hyperperfusion in a wide variety of disease processes. The causes of hyperperfusion at clinical ASL have not been previously characterized. Focal lesions such as brain tumors and vascular malformations with increased perfusion can be well depicted by ASL. More global causes of hyperperfusion, including postanoxia vasodilation and hypercapnia, may go undetected on conventional MR images, whereas the regional hyperperfusion, which may occur in reversible encephalopathies and luxury perfusion, has been consistently illustrated on ASL cerebral blood flow maps at our institution.
Starch Granule Swelling in Water Vapor Sorption (1952)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStarch Granule Swelling in Water Vapor SorptionN. N. Hellman, T. F. Boesch, and E. H. MelvinCite this: J. Am. Chem. Soc. 1952, 74, 2, 348–350Publication Date (Print):January 1, 1952Publication History Published online1 May 2002Published inissue 1 January 1952https://pubs.acs.org/doi/10.1021/ja01122a016https://doi.org/10.1021/ja01122a016research-articleACS PublicationsRequest reuse permissionsArticle Views341Altmetric-Citations55LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Vascular Effects of Progesterone (2001)

-Vascular actions of progesterone have been reported, independently of estrogen, affecting both blood pressure and other aspects of the cardiovascular system. To study possible mechanisms underlying these effects, we examined the effects of P in vivo in intact rats and in vitro in isolated artery and vascular smooth muscle cell preparations. In anesthetized Sprague-Dawley rats, bolus intravenous injections of P (100 µg/kg) significantly decreased pressor responses to norepinephrine (0.3 µg/kg). In vitro, progesterone (10(-8) to 10(-5) mmol/L) produced a significant, dose-dependent relaxation of isolated helical strips, both of rat tail artery precontracted with KCl (60 mmol/L) or arginine vasopressin (3 nmol/L), and of rat aorta precontracted with KCl (60 mmol/L) or norepinephrine (0.1 µmol/L). In isolated vascular smooth muscle cells, progesterone (5x10(-)(7) mol/L) reversibly inhibited KCl (30 mmol/L) -induced elevation of cytosolic-free calcium by 64.1+/-5.5% (P:<0.05), and in whole-cell patch-clamp experiments, progesterone (5x10(-6) mol/L) reversibly and significantly blunted L-type calcium channel inward current, decreasing peak inward current to 65.7+/-4.3% of the control value (P:<0.05). Our results provide evidence that progesterone is a vasoactive hormone, inhibiting agonist-induced vasoconstriction. The data further suggest that progesterone effects on vascular tissue may, at least in part, be mediated by modulation of the L-type calcium channel current activity and, consequently, of cytosolic-free calcium content.
Building multi-user virtual worlds (2013)

Virtual worlds are areas of simulated space that allow first or third person interaction. Interactions can be real-time events or simulations in environments that allow learners to interact with their surroundings, characters, and objects. The focus of this article is the design and development of an academic course on the topic of multi-user virtual worlds. The objective and learning outcome for this course was to build a multi-player virtual game.
A Rapid Enzyme Immunoassay for Cocaine and Benzoylecgonine Using Glucose Oxidase. (2001)

A rapid enzyme immunoassay (EIA) for cocaine and its main metabolite, benzoylecgonine (BZE), using glucose oxidase (GOD) was established. Drug concentrations in samples were determined by the inhibition test. BZE-conjugated GOD and samples were added into the wells of a 96-well microtest plate coated with anti-BZE monoclonal antibody. After washings, color development was performed by additions of glucose, horse radish peroxidase (HRP) and 3, 3', 5, 5'-tetramethylbenzidine (TMB), which was a non-mutagenic and non-carcinogenic chromogen. The time required for the immune reaction and the subsequent color development was only 12 min in this EIA. The EIA specifically detected cocaine and BZE at the low detection limit, that is, about 45.4 pg/well for cocaine, and 433 pg/well for BZE, respectively. The values were hardly interfered by urine diluted to 10%. The present assay method was rapid, sensitive, simple, and safe, and was easily carried out anyplace a micro-plate reader was available. Therefore, it might be suitable to screen cocaine and BZE in urine at the scene of abuse.
<i>P53</i> deletion is not a frequent event in multiple myeloma (1999)

Recently a high incidence of interstitial deletion of the P53 locus has been reported in multiple myeloma (MM) patients. Considering the importance of such an event, we analysed 79 patients with advanced-stage disease using fluorescence in situ hybridization (FISH). Strikingly, we found only 7/79 patients with a P53 deletion. In order to rule out any differences in probe selection, we reanalysed all the patients with the same probe as that used in a previous study, and confirmed the low incidence of P53 deletion (7/79, 9%). The only explanation is a difference in hybridization efficiency. Since hybridization is far less efficient on malignant plasma cells than on other bone marrow cells we suggest that this poor hybridization efficiency may lead to a false P53 deletion.
Experimental study of the scintillation index of a radially polarized beam with controllable spatial coherence (2013)

Radially polarized (RP) beam with controllable spatial coherence (i.e., partially coherent RP beam) was generated in experiment recently [Appl. Phys. Lett. 100, 051108 (2012)]. In this letter, we report experimental study of the scintillation index of a partially coherent RP beam propagating through thermally induced turbulence. Our results show that a partially coherent RP beam has advantage over a linearly polarized partially coherent beam for reducing turbulence-induced scintillation, which will be useful in free-space optical communications, remote sensing and laser radar systems.
Model-Checking based Verification approach for advanced Industrial Automation solutions (2010)

Modern automation systems shall be able to conjugate increasing complexity of controlled processes with agile production reconfiguration requirements. In such a context, structured design approaches based on formal reference models as well as integrated verification and validation process, have to be adopted. To such an aim, present paper proposes an approach based on Model-Checking methods and tools oriented to the Verification of logic control systems in the field of Industrial Automation. In particular, graphical Stateflow based model deployment, Bounded Model Checking techniques and Model Coverage properties have been considered. Furthermore, the proposed approach have been applied regarding the development of the control solution for an automatic warehouse system integrated into a flexible shoes manufacturing plant.
Evaluation of high density liquid crystal polymer based flex interconnect for supporting greater than 1 TB/s of memory bandwidth (2008)

An LCP flex based interconnect that significantly improves the interconnect density and supports data rates in the range of 10 to 16 Gbps is evaluated to enable future high bandwidth module based memory systems without requiring complex equalization techniques. A mating two-piece, low-profile, high density and small insertion force connector is developed for interfacing the flex to a flip-chip package. The 216 pin connector can support 72 differential pairs in a 6 × 12 array.
Fault-tolerance for multistage interconnection networks (2003)

A new fault-tolerant multistage interconnection network architecture is proposed. Using k redundant processors and f redundant switching elements per stage, the authors scheme can tolerate any k processor failures and any f switching element failures per stage. A fault-tolerant multistage interconnection network constructed using their scheme can operate as if it is a non-redundant multistage interconnection network. That is, no additional control information is necessary for routing even when some initial processors and initial switching elements have already failed and been replaced. Furthermore, the reconfiguring process of replacing failed processors and failed switching elements with spare ones can be carried out distributively. The authors scheme also compares favorably with other proposed fault-tolerant multistage interconnection architectures in terms of extra hardware requirements and it can also provide higher system reliability than other proposed schemes. Finally, even for systems with a large number of processors, n>or=1024, their scheme can still achieve very high reliability. Hence, their scheme is well-suited for use in long-life unmaintained applications.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Natural Language Processing Improves Identification of Colorectal Cancer Testing in the Electronic Medical Record (2011)

Applying NLP to EHR records detected more CRC tests than either manual chart review or billing records review alone. NLP had better precision but marginally lower recall to identify patients who were due for CRC screening than billing record review.
Engineering geological assessment and slope stability (1974)

The previous paper has demonstrated the main means by which geology can control landsliding in natural ground. This control by geology and geological processes in the reduction of landscape during the mass movement portion of the geological cycle is clearly visible around New Zealand and is continuing at present. Man's interference has often accelerated or complicated landsliding and it is the duty of people involved in geomechanics to understand and control landsliding to the best of their ability.
Flexible Packet Matching with Single Double Cuckoo Hash (2017)

In modern switches, a packet can go through a number of processing steps to determine, for example, if the packet has to be discarded due to security policies, if it needs to be marked for quality of service or to determine the next hop for the packet. Most of those steps can be modeled as a matching of some of the packet fields with a set of rules that are stored in the switch. This has been generalized with the adoption of Software Defined Networks, using for example, the Openflow protocol, on which the processing steps are programmable as table matching operations and defined dynamically by a controller. Implementing this flexible packet matching in a switch is challenging, as we need to support multiple matching tables, each having different key size, and the size of the tables should also be programmable. The main options to support multiple tables are to use different memories for each table or to have several tables share the same memories. In the first approach, each table would have to match the size and width of the memories to achieve an efficient memory usage. This is a severe limitation when flexible table size and entry width need to be supported. In the second approach, all the tables can dynamically share the memories, providing better flexibility. The problem is that the width of the memories needs to be dimensioned to support the largest entry size. This leads to significant memory waste for smaller entries. Hash based techniques like cuckoo hashing can be used to efficiently implement exact matching using standard SRAM memories, and are widely used in modern switches. However, current implementations only support entries of one size. This article presents the Single Double cuckoo hash, which can support elements of two sizes. Its main benefit is to improve memory utilization when multiple tables with entries of different sizes share the same memories. This is achieved at the cost of a small increase in circuit complexity.
Amelioration of Ambient Particulate Matter (PM2.5)-Induced Lung Injury in Rats by Aerobic Exercise Training (2021)

Ambient particulate matter (PM<sub>2.5</sub>), as an inflammation-inducing factor, increases the prevalence of lung injury. The aim of this study was to examine the protective effect and mechanism of aerobic exercise on PM<sub>2.5</sub> exposure-induced lung injury. Forty Wistar rats were randomly divided into four groups: sedentary+PM<sub>2.5</sub> exposure, exercise+PM<sub>2.5</sub> exposure, sedentary, and exercise groups. All rats in the exercise-related groups underwent 8-week aerobic interval treadmill training (5daysweek<sup>-1</sup>, 1hday<sup>-1</sup>). PM-exposed rats were exposed to ambient PM<sub>2.5</sub> (6h day<sup>-1</sup>) for 3weeks after the 8-week exercise intervention. Then, ventilation function, histopathological changes, and inflammation responses of pulmonary tissue were examined. Results showed that PM<sub>2.5</sub> exposure induced lung injury as manifested by decreased pulmonary function, abnormal histopathological changes, and increased pro-inflammatory cytokine levels (tumor necrosis factor-α and Interleukin-1α). Aerobic exercise alleviated the airway obstruction, reduced respiratory muscle strength, bronchial mucosal exfoliation, ultrastructure damage, and inflammatory responses induced by PM<sub>2.5</sub> in exercise-related groups. The benefits of exercise were related with the downregulation of p38-mitogen-activated protein kinase (MAPK), and the subsequent inhibition of the pathways of the cyclooxygenase 2 (COX-2) product, prostaglandin E<sub>2</sub> (PGE<sub>2</sub>). Thus, pre-exercise training may be an effective way to protect against PM<sub>2.5</sub>-induced lung inflammatory injury in rats.
Ant Based Adaptive Multicast Routing Protocol (AAMRP) for Mobile Ad Hoc Networks (2009)

Multicasting is effective when its group members are sparse and the speed is low. On the other hand, broadcasting is effective when the group members dense and the speed are high. Since mobile ad hoc networks are highly dynamic in nature, either of the above two strategies can be adopted at different scenarios. In this paper, we propose an ant agent based adaptive, multicast protocol that exploits group members desire to simplify multicast routing and invoke broadcast operations in appropriate localized regimes. By reducing the number of group members that participate in the construction of the multicast structure and by providing robustness to mobility by performing broadcasts in densely clustered local regions, the proposed protocol achieves packet delivery statistics that are comparable to that with a pure multicast protocol but with significantly lower overheads. By our simulation results, we show that our proposed protocol achieves increased Packet Delivery Fraction (PDF) with reduced overhead and routing load.
Longitudinal field studies of infectious bronchitis virus and avian pneumovirus in broilers using type-specific polymerase chain reactions (1999)

In longitudinal studies, 13 flocks were swabbed twice each week for the life of the flock (up to 46 days). The swabs were analyzed by type-specific reverse transcriptase polymerase chain reactions. Massachusetts type vaccinal infectious bronchitis virus (IBVs), applied at the hatchery, were usually maximal during the first week, as expected and, notably, remained detectable for 3 to 4 weeks, occasionally longer. IBV of the 793/B type (also known as 4/91 and CR88) was detected in 11/13 flocks (85%). The time of first detection of 793/B varied over several weeks and was sometimes within the first week in low amounts, which increased gradually. In some flocks, detection of 793/B remained intermittent. IBV types D274 and D1466 were each detected once, in the same flock, for short periods, in low amounts, and in the presence of higher amounts of 793/B. In swabs from a further 30 broiler flocks, plus those already mentioned, there was an incidence for 793/B, D274 and D1466 of 79, 10 and 2%, respectively. Avian pneumovirus (APV) (avian or turkey rhinotracheitis virus) vaccines, applied at the hatchery or later, were either not detected or were detected only after a delay of 1 to 3 weeks. In five flocks that received no APV-A vaccine and two flocks that received only APV type A vaccine, field infection by APV type B was detected but only during the last week or so of life. In six flocks that had received an APV-B vaccine, no field APV-B, differentiated from vaccinal APV-B by restriction enzyme analysis, was detected. In swabs from 30 other flocks, the great majority of which had not been vaccinated against APV, the incidence of APV types B and A was 50 and 3%, respectively. The results show (a) that vaccinal IBV can be detected for several weeks, (b) the dominance of the IBV 793/B type and