gebhart/patrepeval huggingface dataset:
Cre recombinase-dependent expression of a constitutively active mutant allele of the catalytic subunit of protein kinase A (2005)

Using the cre-loxP recombination system, we generated a line of mice expressing a constitutively active catalytic subunit of Protein Kinase A (PKA) in a temporally and spatially regulated fashion. In the absence of cre recombinase the modified catalytic subunit allele is functionally silent, but after recombination the mutant allele is expressed, resulting in enhanced PKA effects at basal cAMP levels. Mice expressing the modified protein in hepatocytes using albumin-cre transgenics show defects in glucose homeostasis, glycogen storage, fructose 2,6-bisphosphate levels, and induction of glucokinase mRNA during feeding. Similar to animals lacking glucokinase in the liver (Postic et al.: J Biol Chem 274:305-315, 1999), these mice also have defects in glucose-stimulated insulin secretion, a hallmark of Type II diabetes. The widespread expression of PKA and the involvement of this kinase in a myriad of signaling pathways suggest that these animals will provide critical tools for the study of PKA function in vivo.
Generalized Analytical Solar Radiation Pressure Modeling Algorithm for Spacecraft of Complex Shape (2004)

Covers advancements in spacecraft and tactical and strategic missile systems, including subsystem design and application, mission design and analysis, materials and structures, developments in space sciences, space processing and manufacturing, space operations, and applications of space technologies to other fields.
Phase Closure Imaging - Theory &PRACTICE (1989)

The current status of the phase closure method in high-resolution optical imaging is reviewed. The various schemes for its application and use at large telescopes are discussed, with particular emphasis placed on the similarities and differences between the radio and optical domains. It is seen to be very closely related to the speckle masking method, but in its simplest implementation suffers from a relatively poor limiting sensitivity of ~ 10 magnitude. Its potential lies in fully exploiting the resolution attainable with very large telescopes and at near infrared wavelengths where the expected signal levels from astrophysically interesting sources rise rapidly.
Preferential expression of cystein-rich secretory protein-3 (CRISP-3) in chronic pancreatitis. (2003)

These results reveal that the distribution of CRISP-3 in gastrointestinal tissues is predominantly in the pancreas. High levels of CRISP-3 in acinar cells dedifferentiating into small proliferating ductal cells in CP and CP-like lesions in pancreatic cancer suggests a role of this molecule in the pathophysiology of CP.
Subjective feelings and changes in body sway following diazepam in sons of alcoholics and control subjects. (1991)

The possible generalization to diazepam of the dampened response to ethanol in sons of alcoholic fathers was evaluated in 62 sons of alcoholics (family history positive [FHP] subjects) and 62 family history negative (FHN) controls (124 men). Following challenges with placebo, .12 and .2 mg/kg of diazepam in three separate sessions, evaluation of subjective feelings and increases in body sway revealed no decreased reaction for FHPs.
A 0.18 μm 90 GHz f/sub T/ SiGe HBT BiCMOS, ASIC-compatible, copper interconnect technology for RF and microwave applications (2003)

We present a self-aligned, 0.18 /spl mu/m emitter width SiGe HBT with f/sub T/ of 90 GHz, f/sub MAX/ of 90 GHz (both at V/sub CB/=0.5 V), NF/sub MIN/ of 0.4 dB, and BV/sub CEO/ of 2.7 V. We also demonstrate that this device is integrable with IBM's 0.18 /spl mu/m, 1.8/3.3 V copper metallization CMOS technology with little effect on the CMOS device properties and design rules.
A multicarrier GMSK modulator for base station (2002)

In conventional base station solutions, transmitted carriers are combined after power amplifiers (PAs). This paper describes an architecture in which four GMSK modulated signals are combined in the digital domain. This saves a large number of analog components, many of which require production tuning. Consequently, an expensive and tedious part of manufacturing is eliminated. The proposed multicarrier GMSK modulator does not use an analog I/Q modulator. Therefore the difficulties of adjusting the dc offset, the phasing and the amplitude levels between the in-phase and quadrature phase signal paths are avoided.
Simulating water with rigid non-polarizable models: a general perspective (2011)

Over the last forty years many computer simulations of water have been performed using rigid non-polarizable models. Since these models describe water interactions in an approximate way it is evident that they cannot reproduce all of the properties of water. By now many properties for these kinds of models have been determined and it seems useful to compile some of these results and provide a critical view of the successes and failures. In this paper a test is proposed in which 17 properties of water, from the vapour and liquid to the solid phases, are taken into account to evaluate the performance of a water model. A certain number of points between zero (bad agreement) and ten (good agreement) are given for the predictions of each model and property. We applied the test to five rigid non-polarizable models, TIP3P, TIP5P, TIP4P, SPC/E and TIP4P/2005, obtaining an average score of 2.7, 3.7, 4.7, 5.1, and 7.2 respectively. Thus although no model reproduces all properties, some models perform better than others. It is clear that there are limitations for rigid non-polarizable models. Neglecting polarizability prevents an accurate description of virial coefficients, vapour pressures, critical pressure and dielectric constant. Neglecting nuclear quantum effects prevents an accurate description of the structure, the properties of water below 120 K and the heat capacity. It is likely that for rigid non-polarizable models it may not be possible to increase the score in the test proposed here beyond 7.6. To get closer to experiment, incorporating polarization and nuclear quantum effects is absolutely required even though a substantial increase in computer time should be expected. The test proposed here, being quantitative and selecting properties from all phases of water can be useful in the future to identify progress in the modelling of water.
VAMS: Verifiable Auditing of Access to Confidential Data (2018)

We propose VAMS, a system that enables transparency for audits of access to data requests without compromising the privacy of parties in the system. VAMS supports audits on an aggregate level and an individual level, by relying on three mechanisms. A tamper-evident log provides integrity for the log entries that are audited. A tagging scheme allows users to query log entries that relate to them, without allowing others to do so. MultiBallot, a novel extension of the ThreeBallot voting scheme, is used to generate a synthetic dataset that can be used to publicly verify published statistics with a low expected privacy loss. We evaluate two implementations of VAMS, and show that both the log and the ability to verify published statistics are practical for realistic use cases such as access to healthcare records and law enforcement access to communications records.
PHOSPHORUS AND POTASSIUM PLACEMENT METHODS FOR CORN AND SOYBEAN: AN IOWA PERSPECTIVE (2009)

Increasing fertilizer prices and awareness of potential impacts of excessive or badly applied nutrients on water quality has renewed interest in fertilizer management strategies that reduce nutrient inputs or improve efficacy. Fertilizer recommendations for phosphorus (P) and potassium (K) in Iowa and most states of the Corn Belt are based on soil testing and maintenance of desirable soil-test values by applying amounts removed with crop harvest. The typical Iowa farmer applies before planting corn the P and K fertilizer needed for corn-soybean rotations. A few farmers, mainly in the northern regions of the state and those using no-till management, also apply starter fertilizer for corn. Iowa research during the 1960s and 1970s showed that application of P and K fertilizer at rates of 20 lb P2O5 or K2O/acre or higher rates applied with planter attachment besides and below the seeds (commonly referred to as the 2x2 method) seldom was more efficient than similar amounts applied broadcast and seldom increased yield significantly in high-testing soils. Corn response to N-P-K starter was more likely for very early planting dates with wet and cold soil and/or high residue cover. Reports of corn responses to starter have been more frequent in northern regions of the Corn Belt, such as in Minnesota and Wisconsin.
Edge position measurement with a scanning probe microscope (1994)

A fundamental requirement in critical dimension measurement is determination of the edge positions. Edge position measurement can be degraded by many sources of error, the probe-sample interaction usually being the most important of them. In most cases a sharp conical probe is adequate to locate the top of an edge, and it can scan the entire edge if the walls are not too steep. We discuss aspects of the measurement that affect the uncertainty, such as tip radius, instrument drift, and surface roughness. Measurements with a conical probe of two samples are included. The first is very thin chrome on a quartz substrate, and the second sample is photoresist on a Si wafer.
Corn distillers' grains and other by-products of alcohol production in blended foods. II. Sensory, stability, and processing studies (1984)

Flavor and storage stability are important factors in selection of by-products from the fermentation of grain for use in blended foods for the Food for Peace program. In addition to alcohol, fermentation of corn produces corn distillers' grain (CDG) and corn distillers' solubles (CDS), which are usually combined to produce corn distillers' grains with solubles (CDGS). Commercial sources of these products were analyzed for changes in peroxide, free fatty acid, and available lysine during storage at 49° C, to establish product stability. A trained taste panel judged the flavor quality of CDGS as poor and unacceptable. The panel judged products containing P5% CDG with a blend of cornmeal, soy flour, and nonfat dry milk solids - known as corn-soy-milk (CSM) - to be significantly lower in flavor quality than CSM alone. Blends containing >5% CDG also produced darker-colored products. Corn-protein concentrate had good flavor characteristics but could not be used in large amounts in blends because of its lysine deficiency. CDG flavor was improved by water washing and hexane:ethanol azeotrope lipid extraction [See preceding abstr. for part I.]
The Teledesic satellite system (2002)

There is a significant worldwide demand for broadband communications capacity. Teledesic plans to meet this demand using a constellation of 924 low-Earth orbit (LEG) satellites operating in Ka-band (30/20 GHz). The Teledesic constellation incorporates over 100000 active-element phased-array antennas. Subscriber terminals will account for an additional 20 million antennas. The Teledesic network will be one of the major consumers of Ka-band GaAs MMICs in the late 1990's. Economies of scale will result in a low per subscriber cost.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Conformational Epitope of the Type III Group B <i>Streptococcus</i> Capsular Polysaccharide (1999)

The protective epitope of the type III group B streptococcal polysaccharide (GBSPIII) is length dependent and conformational. To obtain a more accurate characterization of the conformational epitope, ELISA inhibition and surface plasmon resonance studies were conducted on two GBSPIII-specific mAbs using a large panel of oligosaccharide probes. The results of the studies confirmed that 2 repeating units (RU) is the minimum binding unit and that, while increases in chain length from 2 RU to 7 RU caused further optimization of the epitope, it remained monovalent. A 3-fold increase in affinity was observed between 7 RU and 20 RU, which, by surface plasmon resonance studies on a Fab, was shown to be due to both further optimization of the individual epitope and the occurrence of multivalency of epitope. The data support our hypothesis that the conformational epitope is an extended helical segment of the GBSPIII. GBSPIII exists mainly in the random coil form, which structurally mimics short oligosaccharide self Ags, but it can infrequently and spontaneously form extended helices. Although not prevalent in GBSPIII, the immune system preferentially selects these helical epitopes because they are unique to the polysaccharide. Contrary to a previously proposed model of GBSPIII binding in which the binding of the first Ab propagates a continuum of helical epitopes, our binding kinetics are consistent only with the helical epitope's being discontinuous and infrequent.
Ensembles of Generative Adversarial Networks (2016)

Ensembles are a popular way to improve results of discriminative CNNs. The combination of several networks trained starting from different initializations improves results significantly. In this paper we investigate the usage of ensembles of GANs. The specific nature of GANs opens up several new ways to construct ensembles. The first one is based on the fact that in the minimax game which is played to optimize the GAN objective the generator network keeps on changing even after the network can be considered optimal. As such ensembles of GANs can be constructed based on the same network initialization but just taking models which have different amount of iterations. These so-called self ensembles are much faster to train than traditional ensembles. The second method, called cascade GANs, redirects part of the training data which is badly modeled by the first GAN to another GAN. In experiments on the CIFAR10 dataset we show that ensembles of GANs obtain model probability distributions which better model the data distribution. In addition, we show that these improved results can be obtained at little additional computational cost.
Estimating heart rate and RSA from the mattress‐recorded kinetocardiogram (2007)

This article describes a method for extracting heart rate (HR) and respiratory sinus arrhythmia (RSA) from the kinetocardiogram (KCG) recorded from accelerometers embedded in a mattress topper. Validation has been performed via comparison with simultaneously recorded ECG. All-night estimates of HR and RSA magnitude derived from both methods were highly correlated. KCG-derived estimates of HR were slightly lower, and those of RSA magnitude higher, than those derived from ECG. These biases are consistent with the need to constrain KCG estimation to periods free of body movement. Mattress actigraphy represents a zero-burden method of obtaining intensive longitudinal indices of cardiac status.
Management of Parkinson's disease a review of current and new therapies. (1999)

The management of Parkinson's disease has undergone recent changes with the advent of new therapies, both pharmacotherapy and surgery. Available interventions are discussed. Levodopa remains the mainstay of therapy. New drugs include the dopamine agonists and COMT inhibitors. New dopamine agonists which may have a levodopa "sparing effect;" it has been suggested that some of the drugs should be considered as first line treatments for newly diagnosed Parkinson's disease patients. We review roles of these drugs. The concept of neuroprotection in neurodegenerative disorders such as Parkinson's disease became popular in the mid 1980s and it is hoped that eventually therapy will be directed at slowing progression of the disease. A great deal more work needs to be done before a suitable agent is identified as being neuroprotective. Potential neuroprotective agents are reviewed. Surgical therapies for Parkinson's disease consisting of various forms of lesion surgery as well as stimulation procedures are reviewed. Complications of drug therapy include motor problems such as motor response fluctuations, as well as psychiatric complications including levodopa-induced psychosis. Atypical neuroleptic agents and ECT for psychiatric syndromes associated with Parkinson's disease are discussed. Algorithms for the management of early disease as well as the management of psychosis in Parkinson's disease are included. Treatment options for advanced disease are tabulated.
ARRY-520, a novel KSP inhibitor with potent activity in hematological and taxane-resistant tumor models. (2009)

The data provide a rationale for clinical evaluation of the activity of ARRY-520 in hematological carcinomas and taxane-resistant tumors.
Mixing: Theory and Practice (1986)

Mixing: theory and practice , Mixing: theory and practice , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی
Electrochemical Characterization of a Self-Assembled Polyelectrolyte Film (2003)

Polyelectrolyte thin films constructed using the method proposed by Decher and coworkers are studied using several electrochemical techniques, such as cyclic voltammetry and linear sweep voltammetry with rotative disc electrode. The main goal of this work is to evaluate the influence of the number of layers and the charge of the external layer in thin film permeability. These films seem to have electrochemical properties strongly influenced by deposition conditions. It's shown that the increased number of layers lowers film permeability.
Oil Exudation Property of Asphalts (1950)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOil Exudation Property of AsphaltsF. C. Knowles, F. C. McCoy, H. E. Schweyer, and C. E. WilkinsonCite this: Ind. Eng. Chem. 1950, 42, 11, 2340–2343Publication Date (Print):November 1, 1950Publication History Published online1 May 2002Published inissue 1 November 1950https://pubs.acs.org/doi/10.1021/ie50491a043https://doi.org/10.1021/ie50491a043research-articleACS PublicationsRequest reuse permissionsArticle Views82Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Parallel-beam coupling into channel-cut monochromators using curved graded multilayers (1995)

Parabolically bent multilayers with laterally graded period were applied as condensing reflectors to convert divergent X-rays from laboratory X-ray sources into a parallel beam. Two different modes of coupling such a collimated beam into multi-reflection channel-cut monochromators for high-resolution X-ray diffractometry were tested. (i) Parallel coupling (the scattering vector of the mirror reflection is in the plane of the scattering vectors of the monochromator and the sample) enables one to exploit a wider solid angle range of the X-ray source and to gain nearly two orders of magnitude in intensity. (ii) Crossed coupling (the scattering vector of the mirror reflection is perpendicular to the scattering vectors of the monochromator and the sample) delivers a beam with much reduced vertical divergence. This eliminates the line broadening in rocking curve measurements even for strongly tilted samples.
The Princeton FRC Rotating-Magnetic-Field-Experiment RF System (2007)

The Princeton FRC (PFRC) is a compact device that utilizes odd-parity[1] radio-frequency rotating magnetic fields (RMFo) to heat electrons[2] and drive azimuthal current in a cylindrical plasma column. A serendipitous discovery is that the RF system serves as a useful diagnostic tool, providing data on RF-field penetration into the plasma.[3] Efficient use of RF power is required to accommodate the small size of the device and for its development into a practical fusion reactor. The RF system is described along with its evolution and lessons learned.
Traffic analysis using discrete wavelet transform and Bayesian regression (2013)

Traffic analysis using Discrete Wavelet Transform and Bayesian Regression is used to estimating the size of inhomogeneous traffic, composed of vehicles that travel in different directions without using explicit object segmentation or tracking is proposed. Using the dynamic texture motion model, here the traffic is segmented into components of homogeneous motion. From each segmented region, a set of holistic low-level features are extracted using 4-level discrete wavelet transform. Using the 4 level discrete wavelet transform, I calculate the energy of wavelet coefficients and a function that map features into estimates of the number of vehicle per segment is learned with Bayesian regression. Here two Bayesian regression models are examined. The first is a Gaussian Process Regression with a compound kernel, which accounts for both the global and local trends of the count mapping but is limited by the real-valued outputs that do not match the discrete counts. I addressed this limitation with a second model which is based on a Bayesian treatment of poisson regression that introduces a prior distribution on the linear weights of the model. Experimental results show that regression-based counts are accurate regardless of the traffic size. Velocity of each car can be calculated.
In vivo pharmacology of irindalone, a 5‐HT<sub>2</sub> receptor antagonist with predominant peripheral effects (1989)

Abstract The in vivo effects of irindalone, a newly developed serotonin 2 (5‐HT 2 ) antagonist, have been investigated in comparison with a series of reference compounds. Irindalone potently antagonizes the pressor response induced by 5‐HT in pithed rats, but has a 173 times weaker effect against the α 1 ‐adrenoceptor agonist phenylephrine. Irindalone is relatively weak in rat models detecting central 5‐HT 2 antagonism, that is, inhibition of quipazine‐ or I‐5‐HTP plus citalopram‐induced head twitches, inhibition of I‐5‐HTP plus citalopram‐induced increases of flexor reflexes, and inhibition of the discriminative stimulus properties induced by d‐LSD. Furthermore, it displaces in vivo 3 H‐ketanserin binding in frontal cortex. Irindalone weakly antagonizes the flexor reflex stimulated by the α 1 ‐adrenoceptor agonist St 587. No dopamine receptor inhibition is detected in the methylphenidate gnawing test in mice. High bioavailability is indicated by the identical ED 50 values obtained in the head twitch model after s.c. and p.o. administration. The activity profile of irindalone resembles that of ketanserin except in two characteristics: ketanserin has greater potency than irindalone as an antagonist in the 5‐HTP‐induced flexor reflex, but has a shorter duration of action. The effect of irindalone is stereoselective, since its opposite enantiomer Lu 21‐099 is almost inactive in the models for central and peripheral 5‐HT 2 receptor antagonism. Finally, the effect of repeated treatment with irindalone (18 μmol/kg, p.o., twice daily for 2 weeks) on inhibition of quipazine‐induced head twitches was studied. Two days after the last dose, the potency for inhibiting quipazine was unchanged, indicating that no tolerance to 5‐HT 2 receptor antagonism develops using this dose regimen. It is concluded that irindalone is a potent 5‐HT 2 antagonist with preferential effects at peripheral sites.