gebhart/patrepeval huggingface dataset:
[Pro<sup>11</sup>,<scp>d</scp>-Ala<sup>12</sup>]angiotensin I has rapid onset vasoconstrictor activity in the cat (1997)

Responses to the synthetic substrate [Pro11,D-Ala12]angiotensin I were investigated in the hindlimb vascular bed of the cat, a system in which local angiotensin-converting enzyme activity is high. Under constant-flow conditions, injections of [Pro11,D-Ala12]angiotensin I into the perfusion circuit in doses of 1-300 micrograms caused dose-related increases in perfusion pressure that were rapid in onset and that were not changed by the presence of a time-delay coil in the perfusion circuit upstream from the site of peptide injection. The synthetic substrate was approximately 100-fold less potent than angiotensin I and II, and responses to [Pro11,D-Ala12]angiotensin I were not altered by captopril in a dose that inhibited pressor responses to angiotensin I but did not alter responses to angiotensin II. Responses to [Pro11,D-Ala12]angiotensin I, angiotensin I, and angiotensin II were inhibited by DUP-532 and candesartan but were not altered by the angiotensin AT2 receptor antagonist PD-123319. The present data show that [Pro11,D-Ala12]angiotensin I has significant vasoconstrictor activity in the hindlimb vascular bed of the cat and suggest that responses are mediated by the activation of AT1 receptors and that activation of AT2 receptors is not involved. The present data show that the onset of responses to [Pro11,D-Ala12]angiotensin I and angiotensin II are similar and are not dependent on the action of the angiotensin-converting enzyme. The present data suggest that conversion of the synthetic substrate to an active peptide occurs rapidly within the hindlimb vascular bed or that the peptide may have direct AT1 receptor-stimulating activity.
Crystallographic Orientation-Aligned ZnO Nanorods Grown by a Tin Catalyst (2003)

Well-aligned ZnO nanorods with identical crystallographic orientation have been synthesized using a vapor transport deposition process. Orientation-ordered nanorods grow normal to the c planes of the as-deposited micrometer-sized ZnO rods on a polycrystalline Al2O3 substrate, and each nanorod is along [0001] and enclosed by {21̄1̄0} facet surfaces. The nanorods remain in an identical crystal orientation with a homoepitaxial orientation relationship with the microrod. During the synthesis, reduced Sn from SnO2 powder added to the source materials functions as a catalyst, guiding the orientation-aligned growth of ZnO nanorods. By controlling the growth time at high temperature, uniform lengths of aligned nanorods have been received. This work demonstrates that metallic Sn could be a good candidate for catalyzing the growth of 1D nanostructures.
Investigation of saliva as an alternative matrix to blood for the biological monitoring of inorganic lead (2014)

ICP-MS analysis allows sensitive determination of lead in saliva with low limits of detection. The StatSure device is effective for high occupational exposures, but contamination from the device could confound lower-level measurements. Saliva would only be effective as a surrogate for whole blood for highly-exposed populations, although with further work it may have applications as a biomarker of recent exposure.
Perinatal infection and asthma in the infant (2010)

Epidemiological and clinical studies have provided compelling evidence that suggests a link between the relative lack of infectious diseases and the increase in allergic disorders. Asthma usually starts early in life. The early occurrence of asthma suggests that prinatal influences are of importance.Prenatal or postnatal exposure to endotoxins and other bacterial products may protect against the development of asthma in the infant. We will briefly outline the current state of the relationship of the perinatal infection and asthma in the infant, and focus our review mainly on possible rneehanism of perinatal infection providing protection against asthma in the infant, such as Th1/Th2 immune system, transcription factors, protection by maternal antibodies, endotoxin tolerance, pulmonary inflammation and genetic influences. 

Key words: 
Asthma; Perinatal infection ; Children
Vagus Nerve Stimulation Reduces Body Weight and Fat Mass in Rats (2012)

Among the manifold effects of vagus nerve stimulation (VNS) delivered as an add-on treatment to patients with drug-resistant epilepsy, a moderate loss of body weight has been observed in some individuals. We have now investigated this effect in rats. Exposure of rats to VNS for 4 weeks reduced feed conversion efficiency as well as body weight gain (by ∼25%) and the amount of mesenteric adipose tissue (by ∼45%) in comparison with those in sham-operated control animals. A pair-fed experiment showed that both lower dietary intake and increase energy expenditure independently contributed to the reduction of body weight and mesenteric adipose tissue. Moreover, VNS increased the level of non-esterified fatty acids in plasma and mesenteric adipose tissue by ∼50 and 80%, respectively, without affecting that in the liver. In addition, VNS reduced the amounts of endocannabinoids and increased N-palmitoylethanolamide, an endogenous ligand of the transcription factor PPARα (peroxisome proliferator-activated receptor α) in mesenteric adipose tissue but not in the hypothalamus. These effects were accompanied by increased expression of the gene for brain-derived neurotrophic factor (BDNF) in the hypothalamus and up-regulation of the abundance of PPARα in the liver. Our results suggest that the reduction in body fat induced by VNS in rats may result from the action of both central and peripheral mediators. The reduced feed conversion efficiency associated with VNS may be mediated by hypothalamic BDNF, down-regulation of endocannabinoid tone in mesenteric adipose tissue and a PPARα-dependent increase in fatty acid oxidation in the liver, which in concerted action may account for the anorexic effect and increased energy expenditure.
The Stockholm Consensus Conference on Quality Specifications in Laboratory Medicine, 25-26 April 1999 (1999)

(1999). The Stockholm Consensus Conference on Quality Specifications in Laboratory Medicine, 25-26 April 1999. Scandinavian Journal of Clinical and Laboratory Investigation: Vol. 59, No. 7, pp. 475-475.
Generation and Reactions of Lithiated <i>tert</i>‐Butyl and 2,6‐Di(<i>tert</i>‐butyl)‐4‐methylphenyl Cyclopropanecarboxylates (1986)

Abstract tert ‐Butyl and 2,6‐di( tert ‐butyl)‐4‐methylphenyl (BHT) cyclopropanecarboxylates ( 4 , 6 , 24 , 25 ) are lithiated with LiN(i‐Pr) 2 and t ‐BuLi, respectively. Reactions with alkyl halides, aldehydes, acyl chlorides, and heteroelectrophiles give α‐substituted BHT esters which can be cleaved ( t ‐BuOK/H 2 O/THF) to the corresponding carboxylic acids or reduced (LiAlH 4 /THF) to the cyclopropanemethanols.
Knowledge-based robotics (2005)

A major hurdle in the development of intelligent robots is that we still do not possess efficient computational and representational methodologies for emulating knowledge and expectation driven behavior so basic to human cognition and problem solving. Even if we use techniques such as geometric modeling for representing objects in the robot world, we are still lacking in methods for linking such representations with sensory feedback. In this paper, we have proposed the use of intermediate representations - we call them sensor-tuned representations - for linking CSG based solid modeling with sensory information. We also discuss how sensor-tuned representations are constructed from range data and how object recognition can be done with sensor-tuned representations. Finally, we show results of manipulation experiments produced by the current implementation of the system.
DYNAMIC COHESIVENESS IN A COMMUNICATIVE ENGLISH CLASS (2001)

One of the main features of a communicative English classis activities, organized by the teacher and conducted by studentsperforming certain functions and involving different topics. Theuse of activities has gained much attention. However, the linkbetween activities seems to have been ignored. This paper is anattempt to explore the role of cohesiveness between activities incommunicative teaching. The cohesiveness can be eithermechanical or dynamic. The key is that dynamic cohesivenesscontributes to the atmosphere and effectiveness of communicativeEnglish classroom teaching.
Multi-modality image registration within COVIRA (1995)

In this paper we summarize the work on multi-modality image registration performed within the COVIRA (COmputer VIsion in RAdiology) project (AIM, contract A2003). Algorithms for registration using stereotactic frames, anatomical landmark points and anatomical surfaces are presented. Quantification and correction algorithms for geometric distortion in MR and MRA are discussed. These methods are currently clinically evaluated in six clinical pilot application systems for neuroradiological diagnosis, neurosurgery planning and radiotherapy planning.
Interspecific Variation in the Response of Drosophila to Chemicals and Fruit Odours in a Wind Tunnel. (1985)

The responses of four Drosophila species (D. melanogaster, D. simulans, D. immigrans, D. lativittata) to chemicals were tested in a wind tunnel. Methanol, isopropanol and butanol were unattractive, but there was interspecific variation for four of the five chemicals (ethanol, n-propanol, methyl acetate, acetic acid, acetaldehyde) which were attractants. The responses of these species to four fruit odours (apple, plum, peach, lemon) indicated that D. immigrans preferred lemon odours more than did the other species. The relative attraction of D. immigrans to the other fruit odours depended on the combination in which they were presented. These results are compared with earlier findings from Y-tube olfactometers, and their relevance to differential resource attraction in the wild is discussed.
Ring-Opening Polymerization of <scp>l</scp>-Lactide Initiated by (2-Methacryloxy)ethyloxy−Aluminum Trialkoxides. 1. Kinetics (1999)

Kinetic aspects of the synthesis of (2-methacryloxy)ethyloxy functionalized poly(l-lactide) macromonomers using aluminum mono- and trialkoxides carrying this functionality are presented. The results show the living character of the ring-opening polymerization independently of the reaction temperature, but there are some deviations of the classical first order with respect to the monomer concentration, particularly at 60 °C and for low monomer/aluminum catalyst ratios. The comparative study of aluminum trialkoxides with respect to the corresponding monoalkoxides makes clear that the polymerization initiated by trialkoxides is at least five times faster than that initiated by the monoalkoxide. This behavior is explained by taking into consideration semiempirical calculations based on the PM-protocol, which gives an idea of the reactivity of mono- and trialkoxides with good agreement between theoretical and experimental results.
Switchable thiophene coordination in Ru(ii) bipyridyl phosphinoterthiophene complexesElectronic supplementary information (ESI) available: synthetic details and characterization data for all complexes. See http://www.rsc.org/suppdata/cc/b2/b209035j/ (2002)

Switching between P,S- and P,C coordination modes of 3'-phosphinoterthiophene to Ru(II) results in substantial differences in the electronic spectra and cyclic voltammetry of these complexes.
MnO<sub>2</sub> Promoted Sequential C–O and C–N Bond Formation via C–H Activation of Methylarenes: A New Approach to Amides (2013)

A novel and efficient approach for the synthesis of amides has been developed through manganese dioxide promoted nondirected C-H activation of methylarenes under mild reaction conditions employing N-chloroamines as effective coupling partners.
Nerve growth factor increases activity of ornithine decarboxylase in superior cervical ganglia of young rats. (1977)

Nerve growth factor produces a rapid increase in the activity of ornithine decarboxylase (L-ornithine carboxy-lyase, EC 4.1.1.17) in superior cervical ganglia of young rats in vivo and in vitro. Maximum activity occurs 6-7 hr after the addition of nerve growth factor. The nerve growth factor-mediated increase in ornithine decarboxylase activity in vitro can be prevented by the addition of cycloheximide, actinomycin D, or antibody to nerve growth factor. A number of other agents were tested for their ability to increase ornithine decarboxylase were tested for their ability to increase ornithine decarboxylase activity in the ganglia; only nerve growth factor, and, to a slight extent, insulin were able to raise the activity of the enzyme. High concentrations of dibutyryl cyclic AMP (10 mM) were able to mimic the effect of nerve growth factor.
Monitoring of Clopidogrel Action: Comparison of Methods (2005)

VASP phosphorylation assays are reliable for quantifying clopidogrel effects. Because the VASP assay directly measures the function of the clopidogrel target, the P2Y12 receptor, the assay is selective for clopidogrel effects rather than effects of other platelet inhibitors commonly in use.
Electrochemical preconcentration of metals using mercury film electrodes followed by electrothermal vaporization into inductively coupled plasma and determination by atomic emission spectrometry (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectrochemical preconcentration of metals using mercury film electrodes followed by electrothermal vaporization into inductively coupled plasma and determination by atomic emission spectrometryHenryk. Matusiewicz, Judith. Fish, and Tadeusz. MalinskiCite this: Anal. Chem. 1987, 59, 18, 2264–2269Publication Date (Print):September 15, 1987Publication History Published online1 May 2002Published inissue 15 September 1987https://pubs.acs.org/doi/10.1021/ac00145a012https://doi.org/10.1021/ac00145a012research-articleACS PublicationsRequest reuse permissionsArticle Views120Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Generation of Novel Anti-MUC1 Monoclonal Antibodies with Designed Carbohydrate Specificities Using MUC1 Glycopeptide Library (2017)

Numerous anti-mucin 1 (anti-MUC1) antibodies that recognize <i>O</i>-glycan core structures have already been developed. However, most of them show low specificities toward <i>O</i>-glycan structures and/or low affinity toward a monovalent epitope. In this study, using an MUC1 glycopeptide library, we established two novel anti-MUC1 monoclonal antibodies (1B2 and 12D10) with designed carbohydrate specificities. Compared with previously reported anti-MUC1 antibodies, 1B2 and 12D10 showed quite different features regarding their specificities, affinities, and reactivity profiles to various cell lines. Both antibodies recognized specific <i>O</i>-glycan structures at the PDT*R motif (the asterisk represents an <i>O</i>-glycosylation site). 1B2 recognized <i>O</i>-glycans with an unsubstituted <i>O</i>-6 position of the GalNAc residue (Tn, T, and 23ST), whereas 12D10 recognized Neu5Ac at the same position (STn, 26ST, and dST). Neither of them bound to glycopeptides with core 2 <i>O</i>-glycans that have GlcNAc at the <i>O</i>-6 position of the GalNAc residue. Furthermore, 1B2 and 12D10 showed a strong binding to not only native MUC1 but also 20-mer glycopeptide with a monovalent epitope. These anti-MUC1 antibodies should thus become powerful tools for biological studies on MUC1 <i>O</i>-glycan structures. Furthermore, the strategy of using glycopeptide libraries should enable the development of novel antibodies with predesigned <i>O</i>-glycan specificities.
Stromal mesenteric lymph node cells are essential for the generation of gut-homing T cells in vivo (2008)

T cells primed in the gut-draining mesenteric lymph nodes (mLN) are imprinted to express alpha4beta7-integrin and chemokine receptor CCR9, thereby enabling lymphocytes to migrate to the small intestine. In vitro activation by intestinal dendritic cells (DC) or addition of retinoic acid (RA) is sufficient to instruct expression of these gut-homing molecules. We report that in vivo stroma cells, but not DC, allow the mLN to induce the generation of gut tropism. Peripheral LN (pLN) transplanted into the gut mesenteries fail to support the generation of gut-homing T cells, even though gut-derived DC enter the transplants and prime T cells. DC that fail to induce alpha4beta7-integrin and CCR9 in vitro readily induce these factors in vivo upon injection into mLN afferent lymphatics. Moreover, uniquely mesenteric but not pLN stroma cells express high levels of RA-producing enzymes and support induction of CCR9 on activated T cells in vitro. These results demonstrate a hitherto unrecognized contribution of stromal cell delivered signals, including RA, on the imprinting of tissue tropism in vivo.
Compatibility of impulse modulation techniques with attitude sensor noise and spacecraft maneuvering (1965)

Three impulse modulation techniques, each of which provides precision control of spacecraft attitude together with excellent fuel economy during limit cycle operation, are evaluated comparatively in terms of compatibility with sensor noise and with maneuver (plus damping) requirements. Analog computation is used to efficiently simulate sensor noise and controller nonlinearities. Typical response plots demonstrate performance variations (attitude accuracy, rates, fuel economy, jet duty cycle, etc.) as functions of switching hysteresis, sensor noise spectrum, filter parameters and controller parameters. Based on analog results and theoretical correlation, design guides are evolved for selecting control system parameters and minimizing jet fuel usage in terms of mission performance requirements and sensor noise characteristics.
Crystal Structure of KLHL3 in Complex with Cullin3 (2013)

KLHL3 is a BTB-BACK-Kelch family protein that serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. KLHL3 is highly expressed in distal nephron tubules where it is involved in the regulation of electrolyte homeostasis and blood pressure. Mutations in KLHL3 have been identified in patients with inherited hypertension disorders, and several of the disease-associated mutations are located in the presumed Cul3 binding region. Here, we report the crystal structure of a complex between the KLHL3 BTB-BACK domain dimer and two copies of an N terminal fragment of Cul3. We use isothermal titration calorimetry to directly demonstrate that several of the disease mutations in the KLHL3 BTB-BACK domains disrupt the association with Cul3. Both the BTB and BACK domains contribute to the Cul3 interaction surface, and an extended model of the dimeric CRL3 complex places the two E2 binding sites in a suprafacial arrangement with respect to the presumed substrate-binding sites.
Development of Surrogate Reservoir Models (SRM) for Fast-Track Analysis of Complex Reservoirs (2006)

Abstract Reservoir simulation has become the industry standard for reservoir management. It is now used in all phases of field development in the oil and gas industry. The full field reservoir models that have become the major source of information and prediction for decision making are continuously updated and major fields now have several versions of their model with each new version being a major improvement over the previous one. The newer versions have the latest information (geologic, geophysical and petro-physical measurements, interpretations and calculations based on new logs, seismic data, injection and productions, etc.) incorporated in them along with adjustments that usually are the result of single-well or multi-well history matching. A typical reservoir model consists of hundreds of thousands and in many cases millions of grid blocks. As the size of the reservoir models grow the time required for each run increases. Schemes such as grid computing and parallel processing helps to a certain degree but cannot close the gap that exists between simulation runs and real-time processing. On the other hand with the new push for smart fields (a.k.a. i-fields) in the industry that is a natural growth of smart completions and smart wells, the need for being able to process information in real time becomes more pronounced. Surrogate Reservoir Models (SRMs) are the natural solution to address this necessity. SRMs are prototypes of the full field models that can run in fractions of a second rather than in hours or days. They mimic the capabilities of a full field model with high accuracy. These models can be developed regularly (as new versions of the full field models become available) off-line and can be put online for automatic history matching and real-time processing that can guide important decisions. SRMs can efficiently be used for real-time optimization, real-time decision making as well as analysis under uncertain conditions. This paper presents a unified approach for development of SRMs using the state-of-the-art in intelligent systems techniques. An example for developing an SRM for a giant oil field in the Middle East is presented and the results of the analysis using the SRM for this field is discussed. In this example application SRM is used in order to analyze the impact of the uncertainties associated with several input parameters into the full field model.
Karl Pearson and Statistics (1978)

Karl Pearson (1857-1936) is often considered to be the father of the modern discipline of statistics, which emerged from his work in mathematical biology or biometry. Pearson's statistics was, by turn, integrally linked with attempts to establish eugenics as the queen of the social sciences. This paper argues that to understand (i) Pearson's taking to biometry, (ii) biometry's power to yield developments in statistics, and (iii) the association of eugenics with statistics, we must understand Pearson's philosophical and social views, developed before he took to biometry. The closing section of the paper analyzes the ways in which Pearson formed these views in response to the social and intellectual problems posed to him by the conditions of his late-Victorian life. The possibility of explaining the particular pattern of his response in terms of the natural interests of persons occupying his social position is mentioned, as are the difficulties of such an explanatory strategy.