gebhart/patrepeval huggingface dataset:
Refactoring for Asynchronous Execution on Mobile Devices (2015)

To improve responsiveness, developers often use asynchronous programming. In the post-PC era, asynchronous programming is even more in demand because mobile and wearable devices have limited resources and access the network excessively. One current development task is refactoring long-running, blocking synchronous code (for example, accessing the Web, a cloud, a database, or a file system) into nonblocking asynchronous code. This article describes the refactorings that improve responsiveness, along with the obstacles of using asynchrony. It also discusses the challenges of retrofitting asynchrony and presents program analyses and transformations and a growing, practical toolset and resources for retrofitting asynchrony. This article is part of a special issue on Refactoring.
Virucidal Effects of the Steam Distillate from<i>Houttuynia cordata</i>and its Components on HSV-1, Influenza Virus, and HIV (1995)

The steam distillate prepared from fresh plants of Houttuynia cordata Thunb. (Saururaceae) was found to have direct inhibitory activity against herpes simplex virus type 1 (HSV-1), influenza virus, and human immunodeficiency virus type 1 (HIV-1) without showing cytotoxicity, but not against poliovirus and coxsackie-virus. The loss of viral infectivity was related to the duration of drug treatment. Three major components of the distillate, methyl n-nonyl ketone, lauryl aldehyde, and capryl aldehyde, also inactivated HSV-1, influenza virus, and HIV-1. These in vitro findings demonstrate that the essential oils provide virucidal activity against enveloped viruses by interfering with the function of virus envelope.
SpoIIE mutants of Bacillus subtilis comprise two distinct phenotypic classes consistent with a dual functional role for the SpoIIE protein (1996)

Mutations in the spoIIE locus of Bacillus subtilis block sporulation at the stage of asymmetric septation and prevent compartment-specific activation of the transcription factor delta F. Recent ultrastructural studies of spoIIE mutants led to the conclusion that cells blocked at the stage of asymmetric septation form primarily thick septal structures similar to those formed at the mid-cell site during vegetative growth, although in an earlier study Piggot (J. Bacteriol. 114:1241-1253, 1973) clearly detected a more complex range of phenotypes. We have examined the phenotypes of six spoIIE mutants, including one example of the previously studied null type, spoIIE21. We confirmed that the spoIIE21 mutant and two other null mutants exhibit the classic thick-septum phenotype. However, two of the missense mutants, the spoIIE64 and spoIIE71 mutants, were found to display a strikingly different phenotype characterized by the presence of only thin asymmetric septa, frequently at both polar positions, as noted by Piggot. This phenotype is essentially identical to those of spoIIA (delta F) and spoIIG (delta E) null mutants, which also form sporulation septa that appear structurally normal at the level of electron microscopy. Despite the formation of apparently normal asymmetric septa, spoIIE64 and spoIIE71 mutants are fully defective in activation of delta F-dependent gene expression. These results indicate that the functional roles performed by SpoIIE in septum assembly and sigma factor regulation are distinct and separable.
Digital subtraction contrast echocardiography: a new method for the evaluation of regional myocardial perfusion. (1988)

The potential of contrast enhanced digital subtraction echocardiography to demonstrate and quantitate myocardial perfusion was evaluated in 36 patients undergoing routine coronary arteriography or angioplasty. In 24 technically successful studies, multiple cross sectional echocardiographic images, obtained before and after intracoronary (sonicated contrast) injection, were stored by high speed, real time data transfer to an on line minicomputer. Subsequent digital subtraction processing of the stored image data provided composite images in which the distribution of myocardial perfusion was easily seen. Quantitative analysis of peak enhanced myocardial grey level and washout half time successfully differentiated between myocardial segments in which angiography had suggested normal, reduced, and grossly impaired or absent perfusion. The results suggest that this new method of digital image capture and quantitative processing has substantial advantages over previous off line qualitative techniques. It is likely to be of considerable value for routine coronary arteriography, angioplasty, and coronary thrombolysis.
Determining climate effects on US total agricultural productivity (2017)

The sensitivity of agricultural productivity to climate has not been sufficiently quantified. The total factor productivity (TFP) of the US agricultural economy has grown continuously for over half a century, with most of the growth typically attributed to technical change. Many studies have examined the effects of local climate on partial productivity measures such as crop yields and economic returns, but these measures cannot account for national-level impacts. Quantifying the relationships between TFP and climate is critical to understanding whether current US agricultural productivity growth will continue into the future. We analyze correlations between regional climate variations and national TFP changes, identify key climate indices, and build a multivariate regression model predicting the growth of agricultural TFP based on a physical understanding of its historical relationship with climate. We show that temperature and precipitation in distinct agricultural regions and seasons explain ∼70% of variations in TFP growth during 1981-2010. To date, the aggregate effects of these regional climate trends on TFP have been outweighed by improvements in technology. Should these relationships continue, however, the projected climate changes could cause TFP to drop by an average 2.84 to 4.34% per year under medium to high emissions scenarios. As a result, TFP could fall to pre-1980 levels by 2050 even when accounting for present rates of innovation. Our analysis provides an empirical foundation for integrated assessment by linking regional climate effects to national economic outcomes, offering a more objective resource for policy making.
Establishment of an IL‐2‐dependent cell line derived from ‘nasal‐type’ NK/T‐cell lymphoma of CD2<sup>+</sup>, sCD3<sup>−</sup>, CD3ɛ<sup>+</sup>, CD56<sup>+</sup> phenotype and associated with the Epstein‐Barr virus (1998)

A novel interleukin-2 (IL-2)-dependent cell line, HANK1, was established from a patient with CD56+ NK/T-cell lymphoma arising in the retroperitoneum. Morphologically, HANK1 is a pleomorphic large cell line with irregular nuclei, which contains azurophilic granules in the cytoplasm. Immunophenotypic analysis showed that HANK1 expressed CD2, CD3epsilon, CD56, TIA-1, granzyme B, and HLA-DR, but no other T-lineage markers. These features were the same as seen in the original tumour, and are highly characteristic of nasal and 'nasal-type' NK/T-cell lymphoma as described in the proposed W.H.O. classification. Genotypically, this cell line also demonstrated the germline configuration of the T-cell receptor beta, gamma and the immunoglobulin heavy chain genes and clonal integration of the Epstein-Barr virus (EBV) together with antigen expression with a type II latency pattern (LMP-1+ and EBNA2-). Furthermore, Southern blot analysis using the EBV termini as probes confirmed its derivation from the original lymphoma, and revealed that it contained multiple copies of the EBV genome. Dose-dependent growth on IL-2 was observed in an in vitro study with a doubling time of 3 d at maximal stimulation. These data indicate that HANK1 seemed to preserve the biological characteristics of the original tumour and therefore may serve as a good model for the further analysis of unusual 'nasal-type' NK/T-cell lymphoma.
A pulse arrival-time recording module for analyzing neutron multiplicities (2003)

A CAMAC module that is an integral part of a new technique for analyzing neutron multiplicities has been developed. The technique involves sequentially recording the arrival time of pulses from neutron detectors, and then applying correlation algorithms to determine neutron multiplicities. This provides a flexible and more thorough data analysis compared with current methods. The dead-time contribution of this module is virtually zero for the intended applications. By using user-programmable gate arrays and fast static-memory modules, one can fit the entire design into one CAMAC module.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Beiträge zur Entwicklung Wasser speichernder Materialien auf Basis von Stärke und Lignin (2008)

Vor dem Hintergrund des weltweit wachsenden Bedarfes an Bodenverbesserungsmitteln, durch die Humus-, Nährstoff- und Wassermangel auf Problemstandorten kompensiert werden sollen, war es das Ziel der vorliegenden Arbeit, Bodenwasser-speicher auf Basis der nachwachsenden Biopolymere Stärke und Lignin zu entwickeln. Durch Derivatisierung der Stärke wurde deren Hydrophilie deutlich gesteigert, was Voraussetzung für die Bildung von Hydrogelen war. Es konnte gezeigt werden, dass durch Vernetzung der wasserlöslichen Stärkederivate Carboxymethylstärke und Monostärkemonophosphat mit Di-/Tricarbonsäuren quellfähige Hydrogele erzeugt werden, deren Quellungsvermögen und rheologische Eigenschaften über die Wahl des Vernetzers und die Vernetzerstoffmenge gezielt eingestellt werden können. Die Modifizierung von Lignin wurde durch Oxidation mit Wasserstoffperoxid, z.T. in Kombination mit Fe(II)- bzw. Mn(II)-Chloriden realisiert. Dadurch wurde die Vernetzbarkeit von Lignin deutlich verbessert, was auf oxidativ bedingte Strukturänderungen des Lignins zurückzuführen war. Diese bestanden im Wesentlichen in der Spaltung und Oxidation der Lignin-Seitenkette sowie der Hydroxylierung der Seitenkette und aromatischer Strukturen. Die Vernetzung von Lignin mit Poly-(ethylenglycol)-diglycidylether ergab quellfähige Hydrogele, deren Wasseraufnahmevermögen und rheologische Materialfunktionen von der eingesetzten Vernetzerstoffmenge abhängig sind. Es konnte gezeigt werden, dass durch den Einsatz von Stärkephosphat- und Lignin-Hydrogelen das Wasserspeichervermögen erhöht und die Evaporationsraten eines entsprechend behandelten Sandbodens verringert werden. Im Wachstumsversuch wurden die Frischmasseerträge von Gelbsenf (Sinapis alba) durch Behandlung eines Sandbodens mit Hydrogelen gesteigert.
A fluoride borehole dilution apparatus for groundwater velocity measurements (1977)

A borehole dilution method using fluoride in low concentrations as the tracer and an adapted, commercially available fluoride ion electrode to measure the tracer dilution has been developed and employed at two sites. The sites are shallow groundwater systems consisting of alluvial surficial gravels near Fort Macleod, Alberta, and glaciodeltaic sand deposits at the Chalk River Nuclear Laboratories, Ontario. Zones of relatively high groundwater velocities determined at Fort Macleod with the fluoride apparatus are also evident in the results of a large-scale tracer test that documented chloride profiles over the saturated gravel thickness from point samples at 0.3 m depth intervals. The performance of the fluoride electrode compared favorably with a radio tracer ( 131 I) technique in a simultaneous dilution experiment at the Chalk River site. Other ion-selective electrodes such as the chloride electrode may provide an alternative sensor in areas where hydrochemical conditions may restrict the use of the fluoride electrode.
Health insurance reform: security standards. Final rule. (2003)

This final rule adopts standards for the security of electronic protected health information to be implemented by health plans, health care clearinghouses, and certain health care providers. The use of the security standards will improve the Medicare and Medicaid programs, and other Federal health programs and private health programs, and the effectiveness and efficiency of the health care industry in general by establishing a level of protection for certain electronic health information. This final rule implements some of the requirements of the Administrative Simplification subtitle of the Health Insurance Portability and Accountability Act of 1996 (HIPAA).
THE PREPARATION AND PROPERTIES OF POLYCRYSTALS OF SOLID ELECTROLYTE ULTRAFINE PARTICLES (1996)

We have investigated the transport properties of polycrystals of solid electrolytes, CuBr(I) , CuCl(I) , and AgI, by compressing submicron particles prepared by the evaporation method. The pellets of asgrown CuBr and CuCl particles tend to be contaminated by Cu(II), which may cause charge transport by hole conduction. After the CuCl particles are treated with acetone, the pellet shows significant ionic conduction. The pellet of purified particles 0.4-μ m CuCl has a conductivity of 5×10 −7 Ω −1 cm −1 at 25° C , and activation energy for conduction of 0.44 eV. The 0.7-μ m AgI pellet also shows an enhanced conductivity of 5×10 −5 Ω −1 cm −1 at 25°C, and activation energies of 0.04 eV between 60 and 5° C , and 0.23 eV below −25°C.
A knowledge-based approach to the layout analysis (2002)

In this paper, we present a hybrid approach to the problem of the document analysis in which the document image is segmented by means of a top-down technique and then basic blocks are grouped bottom-up in order to form complex layout components. In this latter process, called layout analysis, only generic knowledge on typesetting conventions is exploited. Such knowledge is independent of the particular class of processed documents and turns out to be valuable for a wide range of documents. Preliminary results of the layout analysis system LEX (Layout EXpert) show the methodological validity of this approach.
A Numerical Procedure for Calculating the Integrated Acoustooptic Effect (1980)

Absrmct-The integrated optical effect of light passing through an ultrasonic field can be numerically calculated from the velocity dip tribution assigned to a planar transducer. The theory is developed for linear acoustics, nonabsorbing media, and normal incidence of Light. As a consequence of the application of the Fourier projection slice theorem, an algorithm based on digital Fourier transforms calculates the integrated optical effect without integration. Demonstrations of the influence of transducer geometry are shown for the integrated optical effect and schlieren patterns based on this effect.
Bacteriophage MS2 Lysis Protein Does Not Require Coat Protein to Mediate Cell Lysis (1983)

We inserted all but the extreme 5' end of a DNA copy of the bacteriophage MS2 lysis gene downstream of a lac-induced promoter on a multicopy plasmid. Upon induction, cells harboring this plasmid began to lyse, showing that phage coat protein is not required for the lytic process itself.
Voice Synthesis for in-the-Wild Speakers via a Phonological Loop. (2017)

We present a new neural text to speech method that is able to transform text to speech in voices that are sampled in the wild. Unlike other text to speech systems, our solution is able to deal with unconstrained samples obtained from public speeches. The network architecture is simpler than those in the existing literature and is based on a novel shifting buffer working memory. The same buffer is used for estimating the attention, computing the output audio, and for updating the buffer itself. The input sentence is encoded using a context-free lookup table that contains one entry per character or phoneme. Lastly, the speakers are similarly represented by a short vector that can also be fitted to new speakers and variability in the generated speech is achieved by priming the buffer prior to generating the audio. Experimental results on two datasets demonstrate convincing multi-speaker and in-the-wild capabilities. In order to promote reproducibility, we release our source code and models: PyTorch code and sample audio files are available at ytaigman.github.io/loop.
Comparison of Bernoulli and Gaussian HMMs Using a Vertical Repositioning Technique for Off-Line Handwriting Recognition (2012)

In this paper a vertical repositioning method based on the center of gravity is investigated for handwriting recognition systems and evaluated on databases containing Arabic and French handwriting. Experiments show that vertical distortion in images has a large impact on the performance of HMM based handwriting recognition systems. Recently good results were obtained with Bernoulli HMMs (BHMMs) using a preprocessing with vertical repositioning of binarized images. In order to isolate the effect of the preprocessing from the BHMM model, experiments were conducted with Gaussian HMMs and the LSTM-RNN tandem HMM approach with relative improvements of 33% WER on the Arabic and up to 62% on the French database.
Demonstration of a radio-frequency spectrum analyzer based on spectral hole burning (2001)

Spectral hole-burning (SHB) technology is considered for >10-GHz instantaneous bandwidth signal-processing applications. In this context we report on what is believed to be the first demonstration of a SHB microwave spectrometer. A set of gratings engraved in a SHB crystal is used to filter one sideband of the optically carried microwave signal. The setup is confined to narrow-bandwidth operation, over a 35-MHz-wide interval. The first findings confirm the validity of the architecture in terms of spectral resolution, angular channel separation, and simultaneous detection of multiple spectral lines.
Renal agenesis and hypodysplasia in <i>ret-k</i> <i>–</i> mutant mice result from defects in ureteric bud development (1996)

The c-ret gene encodes a receptor tyrosine kinase that is expressed in the Wolffian duct and ureteric bud of the developing excretory system. Newborn mice homozygous for a mutation in c-ret displayed renal agenesis or severe hypodysplasia, suggesting a critical role for this gene in metanephric kidney development. To investigate the embryological basis of these defects, we characterized the early development of the excretory system in mutant homozygotes, and observed a range of defects in the formation, growth and branching of the ureteric bud, which account for the spectrum of renal defects seen at birth. Co-culture of isolated ureteric buds and metanephric mesenchyme show that the primary defect is intrinsic to the ureteric bud. While the mutant bud failed to respond to induction by wild-type mesenchyme, mutant mesenchyme was competent to induce the growth and branching of the wild-type bud. Furthermore, the mutant metanephric mesenchyme displayed a normal capacity to differentiate into nephric tubules when co-cultured with embryonic spinal cord. These findings suggest a model in which c-ret encodes the receptor for a (yet to be identified) factor produced by the metanephric mesenchyme, which mediates the inductive effects of this tissue upon the ureteric bud. This factor appears to stimulate the initial evagination of the ureteric bud from the Wolffian duct, as well as its subsequent growth and branching.
Clue Cells in Bacterial Vaginosis: Immunofluorescent Identification of the Adherent Gram-Negative Bacteria as Gardnerella vaginalis (1989)

Clue cells are epithelial cells covered by adherent gram-negative rods, observed in vaginal smears from women with bacterial vaginosis. Immunofluorescence studies were used to identify the gram-negative bacteria adhering to clue cells. Specific antisera to four common gram-negative vaginal bacteria (Gardnerella, Bacteroides, Fusobacterium, and Mobiluncus) were prepared by long-term, multiple, small-inoculum immunization of rabbits. Cross-reactivity with heterologous common vaginal bacteria was removed by absorption against whole cells of heterologous bacteria and by serial dilution. Gardnerella vaginalis was most often observed adhering to the surface of clue cells and was detected on the surface of exfoliated vaginal epithelial cells significantly more frequently and in higher numbers than were Mobiluncus, Bacteroides, and Fusobacterium, suggesting that this species of gram-negative bacteria is responsible for clue cell formation.
Filtering Random Matrices: The Effect of Incomplete Channel Control in Multiple Scattering (2013)

We present an analytic random matrix theory for the effect of incomplete channel control on the measured statistical properties of the scattering matrix of a disordered multiple-scattering medium. When the fraction of the controlled input channels, m1, and output channels, m2, is decreased from unity, the density of the transmission eigenvalues is shown to evolve from the bimodal distribution describing coherent diffusion, to the distribution characteristic of uncorrelated Gaussian random matrices, with a rapid loss of access to the open eigenchannels. The loss of correlation is also reflected in an increase in the information capacity per channel of the medium. Our results have strong implications for optical and microwave experiments on diffusive scattering media.
Optimization of the N-Lost Drugs Melphalan and Bendamustine: Synthesis and Cytotoxicity of a New Set of Dendrimer−Drug Conjugates as Tumor Therapeutic Agents (2010)

Bendamustine and melphalan are very promising alkylating drugs with applicability in the treatment of various tumoral diseases, e.g., chronic lymphocytic leukemia (CLL) or breast cancer. However, numerous adverse effects limited their use. Therefore, 1,3,5-tris(3-aminopropyl)benzene (G0) and its G1 analogue 3,5-bis(3-aminopropyl)-N-(3-{3,5-bis[3-{3,5-bis(3-aminopropyl)benzoylamino}propyl]phenyl}propyl)benzamide were selected to design cytostatic drug-dendrimer conjugates to achieve tumor cell accumulation by endocytosis as already demonstrated for platinum complexes. The dendrimers act as carriers and an N-(2-hydroxyethyl)maleimide spacer between drug and carrier should guarantee a selective release of the cytostatics in the tumor cells. The resulting cytotoxicity was determined in vitro using the human MCF-7 and MDA-MB-231 breast cancer cell lines. It was demonstrated that melphalan caused cytotoxic effects depending on its free amino group (Boc protection strongly decreased the activity) but independent of a derivation of the carboxylic group (dendrimers and spacer binding). Esterification of bendamustine with the N-(2-hydroxyethyl)maleimide spacer strongly increased the hydrolytic stability of the N-lost moiety, so antiproliferative effects were yet observed in vitro.
Modeling Vehicle Suspension Structural Compliance at Ford Motor Company Using a Coupling of ADAMS™ and MSC/NASTRAN™ (1994)

<div class="htmlview paragraph">The Core Development Technology group at the Ford Motor Company is actively involved in correlating analytical (ADAMS) vehicle models with objective (telemetric) data from instrumented vehicles. In the past, vehicle compliances were introduced into the ADAMS model by using the ADAMS elements; TIREs, nonlinear BUSHINGs and BEAMs. With the advent of ADAMS/FEA™ [<span class="xref">1</span>], a data translator which provides a two-way interface between ADAMS and MSC/NASTRAN, vehicle models may now include the effects of geometrically complex component stiffness and total body compliance in the ADAMS full vehicle simulation. This paper examines the effects of these added compliances on an ADAMS vehicle model by comparing the dynamic toe and camber angles of a vehicle with rigid upper and lower control arms to a vehicle with flexible upper and lower control arms built from MSC/NASTRAN data. The results demonstrate that complex problems can be very efficiently modeled and simulated by combining finite element analysis (MSC/NASTRAN [<span class="xref">2</span>]) and mechanical system simulation (ADAMS [<span class="xref">3</span>]) technologies.</div>