gebhart/patrepeval huggingface dataset:
Effects of Difructose Anhydride III on Calcium Absorption in Small and Large Intestines of Rats (1998)

Difructose anhydride III (DFA III; di-D-fructo-furanose 1,2':2,3' dianhydride) was prepared from inulin with Arthrobacter sp. H65-7 inulin fructotransferase (depolymerizing (inulase II; EC 2.4.1.93). DFA III is not hydrolyzed by enzymes in the small intestine, but is metabolized by microorganisms in the large intestine. We investigated the effects of DFA III on calcium absorption in two experiments. In the in vivo experiment, we examined the effects of DFA III, fructooligosaccharides, and raffinose on calcium absorption in male Sprague-Dawley rats 5 weeks old at start of the experiment and given feed containing 3% of one of these oligosaccharides for two weeks. The apparent calcium absorption was significantly higher in rats fed any of these oligosaccharides than in control rats, and the increase with DFA III was the greatest. Absorption in both the small and large intestines was affected. In rats fed DFA III, the cecal wall thickened and soluble calcium and the amounts of some organic acids were higher than in the control groups. In an in vitro experiment with everted jejunal and ileal sacs of rats, calcium absorption was higher when DFA III was present in the mucosal fluid at all concentrations tested (up to 200 mM). In the jejunal sacs, the increase in calcium absorption depended on the DFA III concentration. In the ileal sacs, the absorption was maximum at 50 mM DFA III and did not increase further at higher concentrations. These results indicate that intact DFA III stimulates calcium absorption in the small intestine, and that cecal fermentation of DFA III may contribute to the increase in calcium absorption by the large intestine.
Contribution of Hydrogen Bonds to Paper Strength Properties (2016)

The objective of this work was to investigate the influence of hydrogen bonds between fibres on static and dynamic strength properties of paper. A commercial bleached pinewood kraft pulp was soaked in water, refined in a PFI, and used to form paper webs in different solvents, such as water, methanol, ethanol, n-propanol and n-butanol, to determine the effect of their dipole moment on static and dynamic strength properties of resulting paper sheets. Paper which was formed in water, being the solvent of the highest dipole moment among the tested ones, showed the highest breaking length and tear resistance. When paper webs were formed in n-butanol, which was the least polar among the solvents, these parameters were reduced by around 75%. These results provide evidence of the importance of water in paper web formation and strong impact of hydrogen bonds between fibres on strength properties of paper.
ChemInform Abstract: RELATION OF N‐ALKOXYBENZIMIDAZOLES TO NUCLEOPHILIC REAGENTS. ATTEMPTS TO SYNTHESIZE N‐HYDROXY‐2‐AMINOBENZIMIDAZOLES (1979)

Abstract Die Nitrophenylharnstoffe (I) liefern bei der Reduktion mit Ammoniumsulfid Aminophenylharnstoffe (II), die sich durch Erhitzen leicht zu Benzimidazolonen (III) cyclisieren lassen.
Temporal skeletonization on sequential data (2014)

Sequential pattern analysis targets on finding statistically relevant temporal structures where the values are delivered in a sequence. With the growing complexity of real-world dynamic scenarios, more and more symbols are often needed to encode a meaningful sequence. This is so-called 'curse of cardinality', which can impose significant challenges to the design of sequential analysis methods in terms of computational efficiency and practical use. Indeed, given the overwhelming scale and the heterogeneous nature of the sequential data, new visions and strategies are needed to face the challenges. To this end, in this paper, we propose a 'temporal skeletonization' approach to proactively reduce the representation of sequences to uncover significant, hidden temporal structures. The key idea is to summarize the temporal correlations in an undirected graph. Then, the 'skeleton' of the graph serves as a higher granularity on which hidden temporal patterns are more likely to be identified. In the meantime, the embedding topology of the graph allows us to translate the rich temporal content into a metric space. This opens up new possibilities to explore, quantify, and visualize sequential data. Our approach has shown to greatly alleviate the curse of cardinality in challenging tasks of sequential pattern mining and clustering. Evaluation on a Business-to-Business (B2B) marketing application demonstrates that our approach can effectively discover critical buying paths from noisy customer event data.
Ethylene can stimulate <i>Arabidopsis</i> hypocotyl elongation in the light (1997)

Ethylene inhibits hypocotyl elongation in etiolated Arabidopsis seedlings. However, when Arabidopsis was grown in the light in the presence of ethylene or its precursor 1-aminocyclopropane-1-carboxylic acid (ACC), a marked induction of hypocotyl elongation occurred. This resulted from an increase in cell expansion rather than cell division. The effects of ethylene and ACC were antagonized by the ethylene action inhibitor Ag+. The elongation response was absent or weakened in a set of ethylene-insensitive mutants (etr1-3, ein2-1, ein3-1, ein4, ain1-10, ein7). With the exception of ein4, the degree of inhibition of hypocotyl elongation was correlated with the strength of the ethylene-insensitive phenotype based on the triple response assay. In addition, the constitutive ethylene response mutant ctr1-1, grown in the light, had a longer hypocotyl than the wild type. Exogenous auxin also induced hypocotyl elongation in light-grown Arabidopsis. Again, the response was abolished by treatment with Ag+, suggesting that ethylene might be a mediator. The results showed that, depending on light conditions, ethylene can induce opposite effects on cell expansion in Arabidopsis hypocotyls.
Rapid T cell receptor modulation accompanies lack of in vitro mitogenic responsiveness of double negative T cells to anti-CD3 monoclonal antibody in MRL/Mp- <i>lpr/lpr</i> mice. (1988)

The role of the CD8-, CD4- (double negative) (DN) T cells accumulating in MRL/Mp-lpr/lpr (lpr) mice is unclear. Although they bear the TCR/CD3, the lpr DN cells do not respond to Ag, and the specificity of TCR/CD3 on these cells is unknown. With the aid of monoclonal anti-murine CD3 epsilon (145-2C11), we have investigated the function of the CD3 molecule on the DN cells. 145-2C11 was not mitogenic for lpr DN lymph node cells (LNC), even in the presence of the phorbol ester 12-O-tetradecanoylphorbol 13-acetate, whereas MRL/Mp-+/+ (+/+) LNC responded strongly. Surprisingly, CD3 modulation induced by 145-2C11 was much more rapid for lpr DN than for +/+ LNC. For example, the modulation observed after 10 min in lpr DN LNC required at least 2 h in +/+ cells. This was not due solely to a property of the 145-2C11 antibody, because both TPA and the F23.1 anti-TCR mAb also provoked a faster modulation of the TCR in lpr DN LNC. Double-staining experiments showed that co-culturing +/+ and lpr DN LNC did not alter their respective rates of modulation, which suggests an intrinsic defect in the lpr DN cells. Moreover, in LNC from 6-wk-old lpr mice (before the appearance of DN cells), as well as in normal phenotype-bearing T cells (CD8+ or CD4+) from 6-mo-old lpr mice, the CD3 modulation was similar to that of +/+ LNC. After modulation, the CD3 molecule was reexpressed at the surface of both +/+ and lpr DN cells during subsequent incubation of the cells without 145-2C11. In addition, spontaneous recycling of CD3 was similar in +/+ and lpr DN LNC. The rapid modulation of the lpr DN TCR/CD3 is presumably related to the anergy of this cell population.
Specific binding of prostaglandin D2 to rat brain synaptic membrane. Occurrence, properties, and distribution. (1982)

Prostaglandin (PG) D2 bound specifically to a particulate fraction rich in the synaptic membrane of rat brain. The binding was dependent on time and temperature, equilibrium being reached after 5 min at 37 degrees C. The specific binding constituted about 70% of the total binding at 37 degrees C, and 55% at 0 degrees C. The maximal binding was obtained in the presence of 100 mM sodium ion and at pH 8. The equilibrium dissociation constant and the maximal concentration of binding sites as determined by Scatchard analysis were 28 +/- 7 nM and 0.45 pmol/mg of protein (n = 3), respectively. Hill coefficient was 1.15, indicating a single entity of binding sites and no cooperativity. The binding sites were highly specific for PGD2; the Ki values for PGD1 and PGF2 alpha were 523 and 693 nM, respectively. Other PGs including 13,14-dihydro-15-keto-PGD2, an inactive metabolite of PGD2, had 150- to 1000-fold lower affinities than PGD2. The binding was inhibited by boiling or treatment with proteases, phospholipases, or beta-galactosidase. The specific activity of PGD2 binding was highest in the pituitary gland, followed by the hypothalamus and the olfactory bulb od the rat brain, this pattern being almost parallel to that of the cytosolic NADP-linked PGD2 dehydrogenase activity. The results suggest that PGD2 plays a significant role in these regions of the rat brain.
Catalysis by Syrian hamster 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Proposed roles of histidine 865, glutamate 558, and aspartate 766 (1994)

We employed the overexpressed catalytic domains of wild-type Syrian hamster 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase, EC 1.1.1.34) and of mutant enzymes E558Q, H865Q, and D766N to investigate the roles of Glu558, His865, and Asp786 in catalysis. Five reactions were studied: reductive deacylation of HMG-CoA or of mevaldyl-CoA to mevalonate, reduction of mevaldehyde to mevalonate, oxidation of mevaldyl-CoA to HMG-CoA, and oxidative acylation of mevaldehyde to HMG-CoA. While only the wild-type enzyme catalyzed all five reactions, mutant enzymes E558Q and H865Q catalyzed other reactions at significant rates. Mutant enzyme D766N, although apparently structurally similar to the wild-type enzyme, was inactive for all five reactions. While an ineffective catalyst for the overall reaction, mutant enzyme H865Q catalyzed the reduction of mevaldehyde to mevalonate at about the wild-type rate. Coenzyme A, which stimulated mevaldehyde reduction by the wild-type enzyme, inhibited mutant enzyme H865Q, apparently due to an impaired ability to protonate the coenzyme A thioanion, CoAS-. Based on these data, we infer that Glu558, His865, and Asp766 function in catalysis at the indicated stage of the overall reaction, [formula: see text] and we propose a revised mechanism for catalysis by mammalian HMG-CoA reductases.
On “Incomplete” Anti-Rh Antibodies: Mechanism of Direct Agglutination Induced by Mercaptoethanol* (1965)

Since there is little, if any, precedent to suggest that the incomplete anti-Rh antibody molecule differs structurally from other 7 S agglutinating or precipitating antibody molecules, we decided to in- vestigate this problem further. Our data, although not in accord with the original postulate of Pirof- sky and Cordova (8, 9), do suggest alternative ex- planations for the phenomenon they described.
Ibudilast (AV-411) (2007)

The treatment of neuropathic pain is a major unresolved medical challenge. Present pharmacotherapies only have modest efficacy and numerous side effects. The use of opioid analgesics is additionally coupled with dependence and withdrawal syndromes. Ibudilast (AV-411) is a non-selective phosphodiesterase inhibitor that is also known to suppress glial cell activation. It has been used clinically for other indications with a good safety profile. As glial cell activation is considered to crucially contribute to neuropathic pain as well as opioid dependence and withdrawal, the authors conceived that ibudilast may be useful for treating these conditions. Preclinical data indicate that ibudilast crosses the blood-brain barrier, is well tolerated, is active on oral administration, reduces glial activation and attenuates pain symptoms in diverse rat models of neuropathic pain. In addition, it enhances acute morphine analgesia and attenuates morphine tolerance and withdrawal. Thus ibudilast may improve opioid efficacy and is a promising therapeutic candidate for neuropathic pain, with a novel mechanism of action.
Myelopeptides: Bone marrow regulatory mediators (1995)

Bone marrow cells of various animal species and men produce a group of bioregulatory peptides called myelopeptides (MPs). A highly purified MP fraction and some individual molecules have been isolated from the supernatant of porcine bone marrow cell cultures by reverse phase chromatography. MPs have a wide spectrum of functional activities: immunoregulatory, differentiating and opiate-like. They evoke 2.5-fold stimulation of antibody production to various antigens. They correct some immune defects in MRL/lpr mice with spontaneous autoimmune disorders that results in 2-fold prolongation of the life span of these mice. MPs influence the differentiation of bone marrow and peripheral blood cells derived from healthy and leukemic donors. They induce terminal differentiation in the leukemic human HL-60 cell line. MPs also show an effect on pain sensitivity. A new immunocorrective drug Myelopid has been developed on the basis of MP mixtures. This drug is effectively used in Russia both in medicine and veterinary practice for prophylaxis and treatment of diseases accompanied by immunodeficiency. Two individual MPs were isolated and identified: Phe-Leu-Gly-Phe-Pro-Thr (MP-1) and Leu-Val-Val-Tyr-Pro-Trp (MP-2). MP-1 displays immunoregulatory activity; MP-2 abolishes the inhibitory effect of leukemic cells on T-lymphocyte functional activity. MPs seem to provide not only immunoregulation but also to participate in complex interactions between different systems in the organism.
Single-parameter characterization of discrete-dislocation pileup tipfield and its application to physically based micro-mechanics (1991)

The equivalence between continuous dislocation pileups and cracks is reviewed. The force on the leading dislocation is defined and a general method of calculation of the force is proposed. The equivalence relations are given. Based on the analysis by Eshelby, Frank, and Nabarro and the numerical calculations by Chou and Li and Armstrong et al, it will be shown that the force, F, on the locked leading dislocation of a discrete pileup is capable of characterizing uniquely the stress, strain, and displacement fields at the tip of the pileup, including the positions of the discrete mobile dislocations behind the leading dislocation. Conversely, the positions of the mobile dislocations can be used to measure F. If the propagation of micro-slips and the initiation of micro-fractures at the tip of a pileup are controlled by resolved shear stress and normal cleavage stress respectively, the resolved shear stress intensity coefficient, ReSIC, and the resolved cleavage stress intensity coefficient, ReCIC, must be constant.
A gimbaled low noise momentum wheel (1993)

The bus actuators are the heart and at the same time the Achilles' heel of accurate spacecraft stabilization systems, because both their performance and their perturbations can have a deciding influence on the achievable pointing accuracy of the mission. The main task of the attitude actuators, which are mostly wheels, is the generation of useful torques with sufficiently high bandwidth, resolution and accuracy. This is because the bandwidth of the whole attitude control loop and its disturbance rejection capability is dependent upon these factors. These useful torques shall be provided, without - as far as possible - parasitic noise like unbalance forces and torques and harmonics. This is because such variable frequency perturbations excite structural resonances which in turn disturb the operation of sensors and scientific instruments. High accuracy spacecraft will further require bus actuators for the three linear degrees of freedom (DOF) to damp structural oscillations excited by various sources. These actuators have to cover the dynamic range of these disturbances. Another interesting feature, which is not necessarily related to low noise performance, is a gimballing capability which enables, in a certain angular range, a three axis attitude control with only one wheel. The herein presented Teldix MWX, a five degree of freedom Magnetic Bearing Momentum Wheel, incorporates all the above required features. It is ideally suited to support, as a gyroscopic actuator in the attitude control system, all High Pointing Accuracy and Vibration Sensitive space missions.
Virulent non-capsulate Yersinia pestis variants constructed by insertion mutagenesis (1995)

Insertion mutagenesis with the help of the plasmid pFS23 was used to generate Yersinia pestis fra mutants. The results of pFra- strain production under non-selective conditions suggested that such Y. pestis variants may be generated in natural plague foci at high frequency and may participate in supporting the epizootic process. Present data suggest that the reduction of virulence in Fra- strains reported by the majority of investigators was connected with the use of Y. pestis variants carrying additional unidentified mutations. It was shown that the loss of the ability to produce capsular antigen (FI) alone or in combination with absence of murine toxin production did not lead to an increase in LD50 absolute values. Simultaneous loss of these two virulence determinants did not influence the duration of survival of the infected animals. However, absence of only FI antigen production in the infecting strain resulted in prolonged survival of the infected animals. Conversion of plague infection from acute to chronic form is probably dependent on the animal host species and the Y. pestis parent strain subjected to mutagenesis.
A Tiny One-chip MOS Color Camera (1980)

2/3インチ受光面のMOS撮像素子と4倍ズームレンズを開発し, 新しいクロック雑音, 固定パターン雑音の低減回路を加えた小形カラーカメラを試作し, ホームビデオ用をめざしたカメラの性能, 機能を検討した.ここではMOS撮像素子を用いたカメラの雑音の特性について述べ, 管球式と同様にカメラの感度がランダム雑音で定まることを示している.
Degrees of Freedom Region of the MIMO <formula formulatype="inline"> <tex>$X$</tex></formula> Channel (2008)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> We provide achievability as well as converse results for the degrees of freedom region of a multiple-input multiple-output (MIMO) <emphasis><formula formulatype="inline"><tex>$X$</tex></formula></emphasis> channel, i.e., a system with two transmitters, two receivers, each equipped with multiple antennas, where independent messages need to be conveyed over fixed channels from each transmitter to each receiver. The inner and outer bounds on the degrees of freedom region are tight whenever integer degrees of freedom are optimal for each message. With <emphasis><formula formulatype="inline"><tex>$M=1$</tex> </formula></emphasis> antennas at each node, we find that the total (sum rate) degrees of freedom are bounded above and below as <emphasis><formula formulatype="inline"> <tex>$1 \leq \eta _{X}^{\star} \leq {{ 4}\over { 3}}$</tex></formula></emphasis>. If <emphasis><formula formulatype="inline"><tex>$M>1$</tex></formula></emphasis> and channel matrices are nondegenerate then the precise degrees of freedom <emphasis><formula formulatype="inline"><tex>$\eta _{X}^{\star} = {{ 4}\over { 3}}M$</tex></formula></emphasis>. Thus, the MIMO <emphasis><formula formulatype="inline"><tex>$X$</tex></formula></emphasis> channel has noninteger degrees of freedom when <emphasis><formula formulatype="inline"> <tex>$M$</tex></formula></emphasis> is not a multiple of <emphasis emphasistype="smcaps"><formula> <tex>$3$</tex></formula></emphasis>. Simple zero forcing without dirty paper encoding or successive decoding, suffices to achieve the <emphasis><formula formulatype="inline"><tex>${{ 4}\over { 3}}M$</tex></formula></emphasis> degrees of freedom. If the channels vary with time/frequency then the <emphasis><formula formulatype="inline"><tex>$X$</tex></formula></emphasis> channel with single antennas <emphasis><formula formulatype="inline"><tex>$(M=1)$</tex></formula></emphasis> at all nodes has exactly <emphasis><formula><tex>${4\over 3}$</tex></formula></emphasis> degrees of freedom. The key idea for the achievability of the degrees of freedom is <emphasis emphasistype="boldital">interference alignment</emphasis>—i.e., signal spaces are aligned at receivers where they constitute interference while they are separable at receivers where they are desired. We also explore the increase in degrees of freedom when some of the messages are made available to a transmitter or receiver in the manner of cognitive radio. </para>
Sensorless control of PMSG-based wind Energy Conversion Systems using a FLL-based synchronization technique (2011)

The continuous and accurate information of generator speed in wind energy application is an essential requirement in order to get the maximum power at given tip speed ratio, since the maximum power is almost an cubic function of generator speed. This paper studies a Frequency Locked Loop (FLL) - based controller for estimating the rotor speed of the Permanent Magnet Synchronous Generator (PMSG) in a Wind Energy Conversion Systems (WECS). The proposed system consist on get the direct sequence component of generator voltage by means a Dual Second Order Generalized Integrator (DSOGI) and applying a FLL for estimating the generator frequency and, hence, its rotor speed. Using a Proportional Resonant (PR) control, the rotor position is not required and thus a lot of mathematical operations are avoided. Simulation using MATLAB/Simulink and PowerSim shows that using a FLL leads to a simpler and reliable sensorless technique.
A DOC2 Protein Identified by Mutational Profiling Is Essential for Apicomplexan Parasite Exocytosis (2012)

Exocytosis is essential to the lytic cycle of apicomplexan parasites and required for the pathogenesis of toxoplasmosis and malaria. DOC2 proteins recruit the membrane fusion machinery required for exocytosis in a Ca(2+)-dependent fashion. Here, the phenotype of a Toxoplasma gondii conditional mutant impaired in host cell invasion and egress was pinpointed to a defect in secretion of the micronemes, an apicomplexan-specific organelle that contains adhesion proteins. Whole-genome sequencing identified the etiological point mutation in TgDOC2.1. A conditional allele of the orthologous gene engineered into Plasmodium falciparum was also defective in microneme secretion. However, the major effect was on invasion, suggesting that microneme secretion is dispensable for Plasmodium egress.
Clavulanic acid, a novel β-lactam isolated from Streptomyces clavuligerus; X-ray crystal structure analysis (1976)

T. T. Howarth, A. G. Brown and T. J. King, J. Chem. Soc., Chem. Commun., 1976, 266b DOI: 10.1039/C3976000266B
Microwave absorption of DNA between 8 and 12 GHz (1982)

Abstract The microwave absorption of aqueous solutions of DNA extracted from E. coli has been studied between 8 and 12 GHz by the use of an optical heterodyne technique. By measuring optically the temperature rise produced in an absorbing sample by pulsed microwave radiation, unambiguous, direct measurement of the microwave absorption is possible. Our results show that E. coli DNA absorbs microwaves in the 8–12‐GHz region substantially more efficiently than water, which is itself an extremely efficient absorber. The observed absorption is featureless and decreases slightly with increasing frequency. These observations are consistent with an explanation involving direct absorption by longitudinal acoustic modes of the double helix.