gebhart/patrepeval huggingface dataset:
New Amine-masking Groups for Peptide Synthesis (1957)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew Amine-masking Groups for Peptide SynthesisFrank C. McKay and Noel F. AlbertsonCite this: J. Am. Chem. Soc. 1957, 79, 17, 4686–4690Publication Date (Print):September 1, 1957Publication History Published online1 May 2002Published inissue 1 September 1957https://pubs.acs.org/doi/10.1021/ja01574a029https://doi.org/10.1021/ja01574a029research-articleACS PublicationsRequest reuse permissionsArticle Views1452Altmetric-Citations234LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Research on a Skin Color Detection Algorithm Based on Self-adaptive Skin Color Model (2010)

Skin color detection is an important subject in computer vision research. Color segmentation takes a great attention because color is an effective and robust visual cue for characterizing an object from the others. To aim at existing skin color algorithms considering the luminance information not enough, a reliable color modeling approach was proposed. It is based on the fact that color distribution of a single-colored object is not invariant with respect to luminance variations even in the Cb-Cr plane and does not ignore the influence on luminance Y component in YCbCr color space. Firstly, according to statistics of skin color pixels, we take the luminance Y by ascending order, divide the total range of Y into finite number of intervals, collect pixels whose luminance belongs to the same luminance interval, calculate the covariance and the mean value of Cb and Cr with respect to Y, and use the above data to train the BP neural network, then we get the self-adaptive skin color model and design a Gaussian model classifier. The experimental results have indicated that this algorithm can effectively fulfill the skin-color detection for images captured under different environmental condition and the performance of the skin color segmentation is significantly improved.
Conversion of Extracted Oil Cake Fibers into Bioethanol Including DDGS, Canola, Sunflower, Sesame, Soy, and Peanut for Integrated Biodiesel Processing (2008)

Abstract We have come up with a novel, integrated approach for making biodiesel by in‐house producion of ethanol after fermentation of hexane extracted edible oil cake fiber. In addition, we have demonstrated how ethanol could be manufactured from commonly available oil cakes (such as canola, sunflower, sesame, soy, peanut) and dried distiller’s grains with solubles (DDGS). The edible oil cakes and DDGS were hexane extracted, ammonia fiber expansion pretreated, enzymatically hydrolysed and fermented to produce ethanol. From all the oil cakes tested in this work, DDGS and peanut oil cake showed the most promising results giving more than 180 g of glucose/kg of oil cake. These two feedstock’s were hydrolyzed at 15% solids loading and fermented by a native strain of Pichia stipitis . Most sugars were consumed during the first 24 h, with no pronounced inhibition of P. stipitis by the degradation products in the hydrolysate. Xylose consumption was more effective for peanut cake hydrolyzate compared to DDGS.
How much do we know about the Bohr effect of hemoglobin? (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHow much do we know about the Bohr effect of hemoglobin?Chien Ho and Irina M. RussuCite this: Biochemistry 1987, 26, 20, 6299–6305Publication Date (Print):October 1, 1987Publication History Published online1 May 2002Published inissue 1 October 1987https://pubs.acs.org/doi/10.1021/bi00394a001https://doi.org/10.1021/bi00394a001research-articleACS PublicationsRequest reuse permissionsArticle Views463Altmetric-Citations58LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Kinematic Carrier Phase Tracking System for High Precision Trajectory Determination (1994)

The processing of GPS carrier phase is a subject that has enjoyed a great deal of attention. For double differenced phase measurements, the integer ambiguities may be resolved by performing a swap of the reference and user receiver antennas or a survey if the baseline is unknown. A variety of techniques have also been proposed for resolving the ambiguities on-the-fly (OTF). The phase observable allows relative positioning accuracies to the centimeter level. Another subject that is the center of intense interest is the terminal homing system. These systems include target recognition/classification algorithms and aimpoint selection. The accuracy requirements for weapon systems employing terminal seekers are quite stringent, usually on the order of a meter. This suggests that relative position derived from the GPS carrier phase is a natural source to evaluate the accuracy of a terminal sensor system. This paper describes the scoring system developed by ARINC Research Corporation for a terminal homing system testbed being developed at Hughes Aircraft Company. An overview of the system configuration is described and flight test results given. The flight test results were obtained from two cases that differed in trajectory dynamics. In both cases, the results indicate that the scoring system will support the accuracy requirements.
EGFR tyrosine kinase inhibition induces autophagy in cancer cells (2012)

The epidermal growth factor receptor (EGFR) signaling pathway is frequently dysregulated in a variety of human malignancies. As a result, agents have been developed to selectively inhibit the tyrosine kinase function of EGFR (EGFR-TKI) for cancer therapy. However, the clinical efficacy of these drugs to date has been limited by both acquired and intrinsic resistance. Macroautophagy, a process of intracellular proteolysis, has been shown to be activated in response to EGFR targeted therapy. However, the specific role of the induction of autophagy remains controversial. Here we show that autophagy is induced in a dose-dependent manner by in vitro treatment of multiple cancer cell lines with EGFR-TKI. Additionally, we find that in cells highly resistant to EGFR-TKI, autophagy is not robustly activated and that co-treatment of these cells with rapamycin, a known inducer of autophagy, can partially restore sensitivity to EGFR-TKI. Finally, we demonstrate that, in resistant cell lines, EGFR-TKI sensitivity can be further inhibited by siRNA-mediated depletion of the critical autophagy protein ATG7. Thus, our data suggests that defective autophagy may be an EGFR-TKI resistance mechanism and that activation of autophagy may be a viable strategy to augment the cytotoxic effect of EGFR-TKIs.
Characterization of granulocyte colony‐stimulating factor receptor expressed on human lymphocytes (2002)

We have studied the characterization of granulocyte colony-stimulating factor receptor (G-CSFR) in human lymphocytes. About one-third to one-quarter of the B lymphocytes from peripheral B-cell sources displayed G-CSF binding on the two-colour immunofluorescence study. The rate of G-CSFR-expressing (G-CSFR+) B cells was higher in bone marrow and cord blood than in peripheral blood, spleen and tonsil. G-CSFR expression was greater in the surface immunoglobulin D (IgD)-positive (sIgD+) B-cell population, but scarce in the sIgD- B-cell population. In tonsil, G-CSFR+ B cells were present among the cells with naive B and germinal-centre B phenotypes, but those with memory B phenotype were rarely found on triple-colour immunofluorescence analysis. Mitogen-activated, but not resting, T lymphocytes also showed G-CSF binding. Several continuous T- and B-cell lines expressed functional G-CSFR, because the addition of G-CSF enhanced the proliferative response of these cell lines. A sequence analysis of G-CSFR mRNA isoforms obtained from the T and B cells revealed that G-CSFR was derived from class I and class IV mRNA. Our results indicated that G-CSFR was constitutively expressed on the B-cell surface and was inducible in T cells.
Uniform Diameter Single Walled Carbon Nanotubes Catalytically Grown in Cobalt-Incorporated MCM-41 (2004)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionUniform Diameter Single Walled Carbon Nanotubes Catalytically Grown in Cobalt-Incorporated MCM-41Dragos Ciuparu, Yuan Chen, Sangyun Lim, Gary L. Haller, and Lisa PfefferleCite this: J. Phys. Chem. B 2004, 108, 28, 10196Publication Date (Web):June 5, 2004Publication History Published online5 June 2004Published inissue 1 July 2004https://pubs.acs.org/doi/10.1021/jp047883rhttps://doi.org/10.1021/jp047883rcorrectionACS PublicationsCopyright © 2004 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views311Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (7 KB) Get e-Alertsclose Get e-Alerts
Two New Isoflavones from <i>Ceiba pentandra </i>and Their Effect on Cyclooxygenase-Catalyzed Prostaglandin Biosynthesis (1998)

The new isoflavone glucoside vavain 3'-O-beta-d-glucoside (1) and its aglycon, vavain (2), were isolated from the bark of Ceiba pentandra, together with the known flavan-3-ol, (+)-catechin, These novel structures were elucidated by one- and two-dimensional NMR experiments and by MS, IR, and UV spectroscopy as 5-hydroxy-7,4',5'-trimethoxyisoflavone 3'-O-beta-D-glucoside (1) and 5,3'-dihydroxy-7,4',5'-trimethoxyisoflavone (2), respectively. The compounds were isolated following bioactivity-directed fractionation, using a cyclooxygenase-1-catalyzed prostaglandin biosynthesis assay in vitro, in which compounds 1 and 2 and (+)-catechin exhibited IC50 values of 381, 97, and 80 microM, respectively (standard: indomethacin, IC50 1,1 microM). When further tested for their inhibitory effects on cyclooxygenase-2-catalyzed prostaglandin biosynthesis, 1 and 2 were found to be inactive (IC50 > 1200 and > 900 microM, respectively).
<p>Fluoroscopy-Guided Percutaneous Sacroplasty for Painful Metastases at the Sacral Ala</p> (2020)

PSP is a safe and effective technique for the palliative treatment of painful metastases involving the sacral ala under fluoroscopic guidance alone. It can relieve pain, reduce disability, and improve function, and is associated with minimal complications.
Angular Diversity Reception at 2290 MC Over a 188-Mile Path (1959)

Experiments were performed over the 188-mile Round Hill-Crawfords Hill path at 2290 mc to determine the feasibility of using angular diversity reception in a tropospheric scatter system. Using a 28-foot reflector, two beams were produced with two separate feed systems. The correlation of the signals received on one of the two beams with that received on the other was determined for various spacing of the beams, as well as for the azimuthal position of the antenna. These experiments show that angular diversity techniques can be effective depending on the proper choice of frequency, antenna size, and beam separation for paths in the neighborhood of 200 miles in length. A substantial "diversity gain" can be achieved even though partial correlation exists. These results also appear to be in good agreement with theoretical predictions for equal means and for the short periods of time applicable to obtaining reliable voice and high speed teletype communications.
Ultralow Power Circuit Design for Wireless Sensor Nodes for Structural Health Monitoring (2016)

Wireless sensor nodes (WSNs) are essential elements for today's structural health monitoring (SHM). As the design technology for WSNs evolves, there have been continuous efforts to address challenges for WSNs such as short lifetime, high power consumption, and bulky volume. Recent trends show energy harvesting becoming a popular solution for extending the lifetime of WSNs; even implementing energy-autonomous systems is an option. Smaller WSN form factors have been developed for volume-limited applications and sensor nodes as small as a few mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> were created with custom-designed integrated circuits (ICs). Custom IC-based sensor nodes enable energy-efficient implementation of WSNs for SHM. Ultralow power circuits with operation power on the order of nanowatts are introduced in this paper. Ultralow power energy harvesters, timers, wakeup receivers, sensing modalities, and microprocessors are expected to significantly extend sensor node lifetime or achieve sensor node operation with ambient energy harvesting.
The kinetics of hemostatic enzyme-antithrombin interactions in the presence of low molecular weight heparin. (1980)

The kinetics of inhibition of four hemostatic system enzymes by antithrombin were examined as a function of heparin concentration. Plots of the initial velocity of factor Xa-antithrombin or plasmin-antithrombin interaction versus the level of added mucopolysaccharide exhibit an ascending limb and subsequent plateau regions. In each case, the kinetic profile is closely correlated with the concentration of the heparin . antithrombin complex formed within the reaction mixture. A decrease in the velocity of inhibition is not observed at high levels of added mucopolysaccharide despite the generation of significant quantities of heparin-enzyme interaction products. The second-order rate constants for the neutralization of factor Xa or plasmin by the mucopolysaccharide . inhibitor complex are 2.4 x 10(8) M-1 min-1 and 4.0 x 10(6) M-1 min-1, respectively. These parameters must be contrasted with the similarly designated constants obtained in the absence of heparin which are 1.88 x 10(5) M-1 min-1 and 4.0 x 10(4) M-1 min-1, respectively. Plots of the initial velocity of the factor IXa-antithrombin or the thrombin-antithrombin interaction versus the level of added mucopolysaccharide exhibit an ascending limb, pseudoplateau, descending limb, and final plateau regions. In each case, the ascending limb and pseudoplateau are closely correlated with the concentration of heparin c antithrombin complex formed within the reaction mixture. Furthermore, the descending limb and final plateau of these two processes coincide with the generation of increasing amounts of the respective mucopolysaccharide-enzyme interaction products. The second-order rate constants for the neutralization of factor IXa or thrombin by the heparin . antithrombin complex are 3.0 x 10(8) M-1 min-1 and 1.7 x 10(9) M-1 min-1, respectively. The second-order rate constants for the inhibition of mucopolysaccharide-factor IXa or mucopolysaccharide-thrombin interaction products by the heparin . antithrombin complex are 2.0 x 10(7) M-1 min-1 and 3.0 x 10(8) M-1 min-1, respectively. These kinetic parameters must be contrasted with similarly designated constants obtained in the absence of mucopolysaccharide which are 2.94 x 10(4) M-1 min-1 and 4.25 x 10(5) M-1 min-1, respectively. Thus, our data demonstrate that binding of heparin to antithrombin is required for the mucopolysaccharide-dependent enhancement in the rates of neutralization of thrombin, factor IXa, factor Xa, or plasmin by the protease inhibitor. Furthermore, a careful comparison of the various constants suggests that the direct interaction between heparin and antithrombin may be largely responsible for the kinetic effect of this mucopolysaccharide.
Transmission Electron Microscopic Observation of AlN/α-Al<sub>2</sub>O<sub>3</sub> Heteroepitaxial Interface with Initial-Nitriding AlN Layer (1995)

The AlN/α-Al 2 O 3 heteroepitaxial interface is investigated using a transmission electron microscope. The epitaxial AlN film is deposited by metalorganic chemical vapor deposition with and without initial nitriding. The initial nitriding method is to convert the α-Al 2 O 3 substrate surface to a nanometer-thick AlN single-crystal buffer layer in NH 3 ambient just before AlN deposition. The (1\bar210)AlN/(1\bar102)α-Al 2 O 3 interface with initial nitriding is found to be atomically flat, and no dislocation inside the postdeposited AlN is observed. We have confirmed that initial nitriding is excellent in improving the crystal quality of the AlN epitaxial layer.
Improved Characteristics of aPC-Resistance Assay:<i>Coatest aPC Resistance by Predilution of Samples With Factor V Deficient Plasma</i> (1996)

Screening for a resistance against activated protein C (aPCR), which is in most cases caused by FV:Q506 mutation, is performed by functional tests measuring the effect of aPC on activated partial thromboplastin time (aPTT). Because of an insufficient discrimination between FV:Q506 mutation negative and positive individuals with the first generation of the functional test Coatest aPC Resistance (Chromogenix AB, Mölndal, Sweden), the definition of an arbitrary cut-off level was only possible using the results of DNA analysis. The use of an arbitrary cut-off level still resulted in unsatisfactory low sensitivity and specificity for the functional test. Thus, time- and cost-consuming DNA analyses had to be performed frequently to establish the diagnosis. The objective of this study was to evaluate an improved version of this assay that uses predilution of samples with factor V deficient plasma containing a heparin neutralizer. Using the data from 32 FV:Q506 mutation positive and 55 mutation negative individuals, the authors calculated a cut-off value resulting in an enhanced sensitivity (0.91 versus 1.0) and specificity (0.77 versus 1.0) compared to the old one. Imprecision was lowered from 5.36% (first generation) to 2.43%, in particular in samples with longer clotting times. In patients with prolonged aPTT, either caused by therapy with oral anticoagulants or heparin, correct results were obtained with the second generation assay, in contrast to the first generation assay. With this second generation assay the number of DNA analyses can be substantially reduced.
Postharvest Stilbene-Enrichment of Red and White Table Grape Varieties Using UV-C Irradiation Pulses (2002)

The red table grape varieties Flame, Red Globe, Crimson, and Napoleon, as well as the white varieties Superior, Dominga, and Moscatel Italica, were irradiated with a previously optimized UV-C postharvest irradiation protocol (510 W, 40 cm, 60 s). The induction kinetics of the stilbenes trans-resveratrol, trans-piceid, trans-piceatannol, trans-astringin, and viniferins was followed by using HPLC-DAD/MS/MS. The most inducible stilbenes were trans-resveratrol, trans-piceatannol, and viniferins. Both quantitative and qualitative differences were observed in both the stilbene induction kinetics and stilbene content in the seven table grapes analyzed here. The total resveratrol content ranged from 0.69 mg/100 g fw (Dominga) to 2.3 mg/100 g fw (Red Globe). The net resveratrol induction ranged from 3.4-fold (Flame) to 2315-fold (Red Globe). The highest viniferins content was observed in the variety Flame (0.73 mg/100 g fw), although the variety Red Globe presented the highest viniferins induction (175-fold). The highest content and induction of piceatannol (0.17 mg/100 g fw and 173-fold, respectively) was observed in the variety Flame. It should be stressed that taking into account the health-beneficial effects claimed for stilbenes, the UV-C irradiated table grapes can be considered as new functional fruits that can supply (a serving of unpeeled 200 g table grapes) the resveratrol content (depending on the variety) equivalent to more than seven glasses of red wine ( approximately 1.5 L) with high resveratrol content.
Manipulation of cold atoms using an optical one-way barrier (2008)

xvi, 119 p. ; ill. (some col.) A print copy of this thesis is available through the UO Libraries. Search the library catalog for the location and call number.
Microtiter Solid-Phase Radioimmunoassay for Hepatitis B Antigen (1973)

A micro-solid-phase radioimmunoassay (micro-SPRIA) for hepatitis B antigen (HB Ag) was developed for use with microtiter serological equipment. Radiolabeled immunoglobulin G was prepared from human and animal sera containing hepatitis B antibody (HB Ab); it was not necessary to isolate specific HB Ab by immunochemical means. A micro-SPRIA prepared with guinea pig reagents was approximately as sensitive as the AusRIA radioimmunoassay, but, like the AusRIA test, yielded false positive results. A micro-SPRIA prepared with human reagents was slightly less sensitive but did not yield false positive results. These micro-SPRIA tests offer several advantages, including conservation of reagents, adaptability to other antigen-antibody systems, ease of performance (especially when testing large numbers of specimens), and economy.
Chronic generalized fibrotic skin lesions from disseminated leishmaniasis caused by <i>Leishmania martiniquensis</i> in two patients from northern Thailand infected with HIV (2015)

Leishmania martiniquensis is a cause of cutaneous leishmaniasis in Thailand.