gebhart/patrepeval huggingface dataset:
Atmospheric Freeze Drying—A Review (2007)

Abstract This review article focuses on the development of atmospheric freeze drying (AFD): technological aspects, product possibilities, physical properties of products, drying kinetics, modeling, and simulation. The main motivation for developing atmospheric freeze drying as a new drying technology is the desire to reduce the energy consumption compared to vacuum freeze drying while maintaining a high product quality. One technical solution of atmospheric freeze drying is a combined atmospheric freeze drying and heat pump system with new environmentally friendly refrigerants. Temperature programs make it possible to customize products with desired qualities and properties, like retained color, instant properties, aroma, and nutritional value. Keywords: Atmospheric freeze dryingModelingPhysiochemical propertiesReviewTechnologies ACKNOWLEDGEMENT The Norwegian Research Council is acknowledged for financing this survey.
Mutations of C-RAF Are Rare in Human Cancer because C-RAF Has a Low Basal Kinase Activity Compared with B-RAF (2005)

The protein kinase B-RAF is mutated in approximately 8% of human cancers. Here we show that presumptive mutants of the closely related kinase, C-RAF, were detected in only 4 of 545 (0.7%) cancer cell lines. The activity of two of the mutated proteins is not significantly different from that of wild-type C-RAF and these variants may represent rare human polymorphisms. The basal and B-RAF-stimulated kinase activities of a third variant are unaltered but its activation by RAS is significantly reduced, suggesting that it may act in a dominant-negative manner to modulate pathway signaling. The fourth variant has elevated basal kinase activity and is hypersensitive to activation by RAS but does not transform mammalian cells. Furthermore, when we introduce the equivalent of the most common cancer mutation in B-RAF (V600E) into C-RAF, it only has a weak effect on kinase activity and does not convert C-RAF into an oncogene. This lack of activation occurs because C-RAF lacks a constitutive charge within a motif in the kinase domain called the N-region. This fundamental difference in RAF isoform regulation explains why B-RAF is frequently mutated in cancer whereas C-RAF mutations are rare.
The Hemodynamic Effects of Treatment with Interleukin-2 and Lymphokine-Activated Killer Cells (1988)

Therapy with high doses of interleukin-2 induces hemodynamic changes consistent with a high-output and low-resistance state similar to changes noted during the early phase of septic shock.
A New Strain of Leuconostoc Oenos for Induced Malo-Lactic Fermentation in Eastern Wines (1977)

A bacterium, isolated from a red table wine made in the laboratory from French-hybrid grapes grown in Pennsylvania following a spontaneous malo-lactic fermentation, was characterized as <i>Leuconostoc oenos</i> and was given the strain designation, PSU-1. It was found to be quite similar in most biochemical characteristics to <i>L. oenos</i> ML-34, a commonly studied strain which was isolated from a California wine. ML-34 and PSU-1 were compared for their growth characteristics in a complex laboratory medium modified to simulate some of the conditions which limit the growth of bacteria in wine. It was found that ML-34 always grew as well as or slightly better than PSU-1 with variations in pH, added ethanol, added sulfur dioxide and different incubation temperatures. Two separate experiments were conducted to compare the strains for induced malolactic fermentation by pure culture inoculation into Pennsylvania red table wines. In the first experiment, three wines made from blends of hot-pressed Pennylvania musts were passed through 0.5 µm filters prior to inoculation. PSU-1 induced malo-lactic fermentation in two of these wines within 11.9 and 15.3 weeks following inoculation, while ML-34 failed to induce malo-lactic fermentation within 50 weeks in all three wines. In the second experiment, bacteria were inoculated into three varietal red Pennsylvania wines made using traditional vinification procedures. Two of the three varieties inoculated with PSU-1 completed malo-lactic fermentation considerably faster than identical wines inoculated with ML-34. In the other variety, wines inoculated with both organisms completed malo-lactic fermentation at about the same time which was much faster than the uninoculated control lots. Sensory evaluation of the varietal wines treated identically, except for the bacterial strain inoculated, revealed that no detectable differences existed in the wines.
Bottom-Up Propositionalization. (2000)

Abstract. In this paper, we present a new method for propositionalization that works in a bottom-up, data-driven manner. It is tailored for biochemical databases, where the examples are 2-D descriptions of chemical compounds. The method generates all frequent fragments (i.e., linearly connected atoms) up to a user-specified length. A preliminary experiment in the domain of carcinogenicity prediction showed that bottomup propositionalization is a promising approach to feature construction from relational data. 1
Synthesis of Microporous Transition Metal Oxide Molecular Sieves with Bifunctional Templating Molecules (1998)

Systematic tuning of the micropore size in microporous transition metal oxide molecular sieves can be achieved by varying the length of the hydrocarbon chain of the diamine molecules used as templating agents. The large bifunctional molecules self-assemble with much smaller cross-sectional micellar dimensions than their monofunctional counterparts. The resulting family of porous materials offers exciting new flexibility in designing molecular sieves targeted for size selectivity and chemical functionality.
Emotion Regulation in Schema Therapy and Dialectical Behavior Therapy (2016)

Schema therapy (ST) and dialectical behavior therapy (DBT) have both shown to be effective treatment methods especially for borderline personality disorder. Both, ST and DBT, have their roots in cognitive behavioral therapy and aim at helping patient to deal with emotional dysregulation. However, there are major differences in the terminology, explanatory models and techniques used in the both methods. This article gives an overview of the major therapeutic techniques used in ST and DBT with respect to emotion regulation and systematically puts them in the context of James Gross' process model of emotion regulation. Similarities and differences of the two methods are highlighted and illustrated with a case example. A core difference of the two approaches is that DBT directly focusses on the acquisition of emotion regulation skills, whereas ST does seldom address emotion regulation directly. All DBT-modules (mindfulness, distress tolerance, emotion regulation, interpersonal effectiveness) are intended to improve emotion regulation skills and patients are encouraged to train these skills on a regular basis. DBT assumes that improved skills and skills use will result in better emotion regulation. In ST problems in emotion regulation are seen as a consequence of adverse early experiences (e.g., lack of safe attachment, childhood abuse or emotional neglect). These negative experiences have led to unprocessed psychological traumas and fear of emotions and result in attempts to avoid emotions and dysfunctional meta-cognitive schemas about the meaning of emotions. ST assumes that when these underlying problems are addressed, emotion regulation improves. Major ST techniques for trauma processing, emotional avoidance and dysregulation are limited reparenting, empathic confrontation and experiential techniques like chair dialogs and imagery rescripting.
DC optimal power flow including HVDC grids (2013)

Many simulations in power systems analysis contain an AC grid which is solved using linearized power flow methods. This paper extends the known DC optimal power flow method for AC grids for use in combined AC and HVDC grids. Future studies would now incorporate in their simulations combined AC and HVDC grids. This paper describes the additions made to the algorithm and the influence of the soft penalties. The algorithm is tested in the IEEE 14 bus test case with a 5 node DC overlay grid. The accuracy compared to the full power flow model is in a reasonable range. The calculation performance is significantly increased.
Mouse Sperm Desiccated and Stored in Trehalose Medium Without Freezing1 (2005)

Mouse sperm with and without trehalose were desiccated under nitrogen gas and stored at 4 degrees C and 22 degrees C. After rehydration, sperm were injected into oocytes using intracytoplasmic sperm injection and embryonic development was followed. Sperm were dried for 5.0, 6.25, or 7.5 min, stored at 22 degrees C for 1 wk with and without trehalose. The percentages of blastocysts that developed from sperm with trehalose were 51%, 31%, and 20%, respectively, which was significantly higher than sperm without trehalose (10%, 3%, and 5%, respectively). Desiccation and storage in medium with trehalose significantly increased sperm developmental potential compared to medium without trehalose. Sperm dried for 5 min produced more blastocysts than sperm dried for 6.25 or 7.5 min. When sperm were dried in trehalose for 5 min and stored for 1 wk, 2 wk, 1 mo, or 3 mo at 4 degrees C, the percentages of blastocysts were 73%, 84%, 63%, and 39%; whereas those stored at 22 degrees C for 1 wk, 2 wk, or 1 mo were significantly lower (53%, 17%, and 6%, respectively). Embryos from sperm partially desiccated in trehalose for 5 min and stored at 4 degrees C for 1 or 3 mo were transferred to 10 pseudopregnant recipients. Implantation rates were 81% and 48%; live fetuses were 26% and 5%, respectively. One of the recipients delivered three live fetuses. The results show that trehalose has a significant beneficial effect in preserving the developmental potential of mouse sperm following partial desiccation and storage at temperatures above freezing.
Ceilbot Development and Integration (2014)

The mobile robots that are present today are struggling to deal with challenges related to localization, power supply, mobility in the real world with all sorts of obstacles and other issues. At the same time, the demand for service robots for domestic applications has been growing and predictions show that the demand will continue to grow in the future. To meet the demands and to fulfill the expectations, those challenges need to be addressed. This thesis presents the development of a ceiling mounted robot known as Ceilbot. It is a type of mobile service robot except that it works on a track attached to the ceiling. This implies that the robot operates in a structured environment with continuous power supply simplifying some of the issues mentioned above. The development of the Ceilbot includes a simplified DC motor controller development, object recognition development and an easy-to-use graphical user interface design. The developed motor controller provides flexibility for the user to change the control parameters and produces deterministic output with high repeatability when compared to a regular proportional and integral (PI) controller. The designed user interface simplifies the interaction between the user and the Ceilbot by allowing the user to send commands to the Ceilbot and displaying some status parameters for monitoring. In order to have a complete robot system for demonstration purposes, a simple manipulator using two servomotors is also developed.
[Postoperative analgesia with PCA in 300 patients. A comparison of four therapeutic regimes]. (1998)

On the basis of personal experience, patient controlled analgesia has been demonstrated to be an effective, reliable and flexible procedure for the control of postoperative pain.
Design and performance of an all-digital adaptive 2.048 Mbit/s data transmission system using noise prediction (2003)

A quaternary digital transmission system for ISDN primary rate access (2.048 Mb/s, Europe) over the twisted wire pair channel is presented. The system permits more than a doubling of the regenerator space as compared to existing systems, although the transmission is affected by severe intersymbol interference and near-end crosstalk. A proposed receiver structure with the threshold detection, adaptive equalization, and adaptive, linear noise prediction achieves the performance of a maximum-likelihood sequence estimator, which would have immense complexity, within 2.4 dB. It is shown that the noise prediction gains some advantages over the conventional decision-feedback equalizer. An implementation of the receiver with high-speed digital-signal processing building blocks, which achieves an efficiency of about 72 MOPS, is described. Measurement results, which demonstrate that the theoretical bound is met within less than 0.5 dB, are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Dualities in 2+1 Dimensions (2018)

In this course, we will discuss dualities in 2+1 dimensions. We begin by briefly reviewing the physics of 1+1d T-duality and bosonization, and discuss flux attachment and the dual photon in 2+1d. Then, we introduce 2+1d particle-vortex duality, bosonization and their associated web of dualities. This includes discussing more elaborate Abelian dualities, including self-dual theories and quiver theories. Next, we move on to non-Abelian physics, discussing QCD in three dimensions and more. This done, we will discuss the relation of these dualities to SUSY dualities, lattice physics, and large $N$ physics; and finally, we present the application of one of the Abelian dualities to quantum Hall physics.
HERG1 functions as an oncogene in pancreatic cancer and is downregulated by miR-96 (2014)

Pancreatic cancer is an aggressive malignancy with an extremely poor prognosis. The human ether-a-go-go-related potassium channel (HERG1) is a human rapid delayed rectifier, which is involved in many crucial cellular events. In this article, we find that HERG1 expression is dramatically increased both in pancreatic cancer tissues and cell lines, and that increased HERG1 expression is significantly related to the development of pancreatic cancer. HERG1 silencing in pancreatic cancer-derived cell lines PANC-1 and CFPAC-1 strongly inhibits their malignant capacity in vitro as well as tumorigenicity and metastasis in nude mice. In addition, HERG1 is identified as a direct target of miR-96, which is downregulated in pancreatic cancer tissues and cell lines. Ectopic expression of miR-96 represses the HERG1 expression in pancreatic cancer and significantly inhibits malignant behavior of pancreatic cancer cells in vitro and in vivo. Collectively, our findings suggest that miR-96 acts as a tumor suppressor in pancreatic cancer and may therefore serve as a useful therapeutic target for the development of new anticancer therapy.
Phosphatase Inhibitor-2 Balances Protein Phosphatase 1 and Aurora B Kinase for Chromosome Segregation and Cytokinesis in Human Retinal Epithelial Cells (2008)

Mitosis in Saccharomyces cerevisiae depends on IPL1 kinase, which genetically interacts with GLC8. The metazoan homologue of GLC8 is inhibitor-2 (I-2), but its function is not understood. We found endogenous and ectopic I-2 localized to the spindle, midzone, and midbody of mitotic human epithelial ARPE-19 cells. Knockdown of I-2 by RNA interference produced multinucleated cells, with supernumerary centrosomes, multipolar spindles and lagging chromosomes during anaphase. These defects did not involve changes in levels of protein phosphatase-1 (PP1), and the multinuclear phenotype was rescued by overexpression of I-2. Appearance of multiple nuclei and supernumerary centrosomes required progression through the cell cycle and I-2 knockdown cells failed cytokinesis, as observed by time-lapse microscopy. Inhibition of Aurora B by hesperadin produced multinucleated cells and reduced H3S10 phosphorylation. I-2 knockdown enhanced this latter effect. Partial knockdown of PP1Calpha prevented multiple nuclei caused by either knockdown of I-2 or treatment with hesperadin. Expression of enhanced green fluorescent protein-I-2 or hemagglutinin-I-2 made cells resistant to hesperadin. We propose that I-2 acts to enhance Aurora B by inhibiting specific PP1 holoenzymes that dephosphorylate Aurora B substrates necessary for chromosome segregation and cytokinesis. Conserved together throughout eukaryotic evolution, I-2, PP1 and Aurora B function interdependently during mitosis.
Shape discrimination in liquid chromatography using charge-transfer phases (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTShape discrimination in liquid chromatography using charge-transfer phasesLane C. Sander, Reenie M. Parris, Stephen A. Wise, and Philippe. GarriguesCite this: Anal. Chem. 1991, 63, 22, 2589–2597Publication Date (Print):November 15, 1991Publication History Published online1 May 2002Published inissue 15 November 1991https://pubs.acs.org/doi/10.1021/ac00022a011https://doi.org/10.1021/ac00022a011research-articleACS PublicationsRequest reuse permissionsArticle Views167Altmetric-Citations58LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Acid Amyloglucosidase and Carbohydrate Regulation (2009)

High activity of the exoamylolytic enzyme, acid amyloglucosidase, was found in isolated pancreatic islets of the mouse. Enzyme activity was optimum at pH 5.0-5.5 and the activity at pH 5.0 was two times that of liver and ten times that of skeletal muscle. Acid amyloglucosidase activity in islets isolated from alloxan diabetic animals was reduced to about 10% of the normal value indicating that the major part of the enzyme activity is confined to islet β-cells. In contrast, islets isolated from insulin-hypersecreting obese mice (AO-mice) were found to have markedly elevated levels of acid amyloglucosidase activity.
Expression of the RESA gene in Plasmodium falciparum isolate FCR3 is prevented by a subtelomeric deletion. (1989)

We show here that the Plasmodium falciparum isolate FCR3 does not express the ring-infected erythrocyte surface antigen (RESA). This is because the 5' end of the RESA gene has been inverted and partly deleted and a telomere has been added to it. We propose a model to explain these events.
The effect of oxygenation on the biological behaviour of tumours (2007)

Malignant tumours often display hypoxic tissue areas where the oxygen tension is < 7 mm Hg. Studies in this field have proved that the hypoxic state boosts tumour progression and aggressive behaviour. In tissue culture experiments "in vitro" oxygenation was found to inhibit in itself the proliferation of cells of healthy tissues as well as benign and malignant tumours. It is a very important observation from oncotherapeutic point of view that in the presence of partial oxygen pressure < 2.5 mm Hg the radiosensitivity decreases (intrinsic radioresistance). Most of the anticancer drugs (cytostatics) are also ineffective in hypoxic tumours (chemoresistance). The same is true for photodynamic treatments in oxygen deficiency or hypoxia. From time to time attempts based on these experimental and clinical observations are made to use oxygenation either as an adjuvant or an independent treatment in tumour patients. The most frequent treatment forms are: inhalation of oxygen gas (hyperbaric oxygen therapy), use of oxygen saturated water either in water or drinking cure. Recent international studies unanimously confirm the beneficial effect of oxygen intake on therapy, radio- and chemosensitization. The widespread erythropoietin treatment underlines the significance of oxygenation in tumour therapy. It seems reasonable to extend the preliminary studies on the tumour inhibitory, radio- and chemosensitizing effect of oxygenation to large study populations in major medical institutes in Hungary.
TREC-IN: gene knock-in genetic tool for genomes cloned in yeast (2014)

Although we have demonstrated the feasibility of TREC-IN in gene complementation and genome minimization studies in Mmc, the applicability of TREC-IN ranges widely. This method proves to be a valuable genetic tool that can be extended for genomic engineering in other genetically intractable organisms, where it may be implemented in elucidating specific metabolic pathways and in rationale vaccine design.
Provincial Administration and Courts (1994)

Abstract The decentralised nature of the Dutch political system meant not only that the central government of the Dutch Republic was very limited in its powers, but also that there was a certain weakness at the centre of provincial government. The most prominent organs of central control outside the States themselves were the provincial courts, and here there were some peculiar features, as both these courts served not just Holland but Zeeland as well, thus constituting a very unusual contravention of the normally watertight separation between the two provinces. These courts were partly the lineal descendants of the court of the counts of Holland and Zeeland, and partly a replacement for the Grote Raad (Great Council) at Mechelen as appeal court. The chapter further discusses the Hof van Holland and the Hoge Raad.
The Colony-Stimulating Factors and Cancer (2013)

The colony-stimulating factors (CSFs) are the master regulators of granulocyte and macrophage populations. There are four different aspects of the connection between the CSFs and cancer: (a) the CSFs can accelerate the regeneration of protective white cells damaged by chemotherapy; (b) the CSFs can mobilize stem cells to the peripheral blood in convenient numbers for transplantation; (c) the CSFs can enhance anticancer immune responses and (d) the CSFs are potentially involved in the genesis of the myeloid leukemias.