gebhart/patrepeval huggingface dataset:
The effect of supplemental lysine and threonine on growth and development of yearling horses3 (1994)

Thirty-nine Thoroughbred and Quarter Horse yearlings were used in two 112-d experiments to determine the effect of lysine and threonine supplementation on growth and development. Yearlings were individually fed three dietary treatments that consisted of a pelleted concentrate containing corn, oats, and soybean meal fed to appetite twice daily and Coastal bermuda grass hay group-fed at a rate of 1 kg/100 kg BW. Three concentrates were tested: (A) basal, (B) basal plus .2% lysine, and (C) basal plus .2% lysine, and .1% threonine. Feed intake, weight, withers height, girth, hip height, body length, and hoof growth (Exp. 1) were recorded every 28 d, and initial and final radiographs taken for estimating bone mineral content. Final croup fat thickness was measured ultrasonically in Exp. 1, and initial and final croup fat measured in Exp. 2. Blood samples were taken every 28 d for determination of serum urea N and protein in Exp. 2. Average daily feed intake (as-fed) was 8.8 +/- .14, 9.0 +/- .13, and 9.2 +/- .13 kg (P < .09), ADG was .57 +/- .02, .64 +/- .02, and .67 +/- .02 kg/d (P < .02), and girth gain was 9.7 +/- .49, 10.1 +/- .46, and 11.3 +/- .47 cm (P < .05) for Treatments A, B, and C, respectively. Gain:feed ratios in Exp. 1 were 70.5, 70.8, and 75.5 g/kg (P > .10) and in Exp. 2 were 61.7, 70.8, and 70.2 g/kg (P < .10) for Treatments A, B, and C, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
High T<sub>c</sub> Magnetic Superconductors in Rare Earth (R) Barium Copper Oxide RBa<sub>2</sub>Cu<sub>3</sub>O<sub>7-δ</sub> (1987)

Superconductivity with critical transition temperature T c near 90 K has been found in RBa 2 Cu 3 O 7-δ compounds where R = Nd, Sm, Eu, Gd, Dy, Ho, Er, Tm, Yb, and Lu, and with T c =56 K for R = La by electrical resistivity and low field magnetic susceptibility measurements. All compounds (except La) form in the orthorhombic, layered perovskite structure which is isomorphic to YBa 2 Cu 3 O 7-δ . The lattice parameters of the compounds decrease in accordance with the metallic radii of the R trivalent ions. The electrical resistivity of the compounds studied (except for R = Nd) decreases with decreasing temperature and exhibit a sharp superconducting transition. Upper critical magnetic field H c2 of the heavy R compounds (R from Dy to Yb) were measured and the highest initial slope |dH c2 /dT c |T c yet found for above 90 K superconductors was exhibited in TmBa 2 Cu 3 O 7-δ with a value of 2.8 tesla/K.
Identification of alg3 in the mushroom-forming fungus Schizophyllum commune and analysis of the Δalg3 knockout mutant (2012)

Alg3 of Saccharomyces cerevisiae catalyzes the mannosyl transfer from Man-P-Dol to Man(5)GlcNAc(2)-PP-Dol resulting in the formation of Man(6)GlcNAc(2)-PP-Dol, which is then further processed to the final precursor oligosaccharide Glc(3)Man(9)GlcNAc(2) for N-glycosylation of proteins. Here, we identified the alg3 gene of the mushroom-forming fungus Schizophyllum commune by homology search. Its function was confirmed by the complementation of the Δalg3 strain of S. cerevisiae. Inactivation of alg3 in S. commune resulted in the production of predominantly Man(3)GlcNAc(2) protein-linked N-glycans. No impact on growth nor a developmental phenotype due to the deletion was observed. This provides a first step toward engineering of a homogeneous, humanized N-glycosylation pattern for the production of therapeutic glycoproteins in mushrooms.
The solute carrier 44A1 is a mitochondrial protein and mediates choline transport (2009)

Choline oxidation to betaine takes place in the mitochondria; however, a protein regulating mitochondrial choline transport was never identified. The purpose of this study was to analyze subcellular localization of the solute carrier 44A1 (SLC44A1), a plasma membrane choline transporter sensitive to inhibition by hemicholinium-3. We generated N- and C-terminal-SLC44A1-specific antibodies and analyzed localization of endogenous and overexpressed SLC44A1 in C2C12 mouse muscle cells, MCF7 human breast cancer cells, and mouse tissues using confocal microscopy, differential centrifugation, and Western blotting. We further performed choline uptake competition studies on isolated mitochondria using the specific inhibitor hemicholinium-3 and SLC44A1 antibodies, and analyzed mitochondria of FL83B hepatocytes after the targeted knock-down of SLC44A1 using siRNA technology. In addition, we analyzed SLC44A1 expression during choline deficiency. Localization studies revealed plasma membrane, cytosolic, microsomal, and mitochondrial localization of endogenous and His-tagged SLC44A1. Uptake studies in isolated mitochondria show an accumulation of (3)H-choline, which is strongly inhibited by hemicholinium-3 (60%), by an excess of unlabeled choline (97%), and by both SLC44A1 antibodies. SLC44A1 mRNA and protein expression were down-regulated during choline deficiency. These data clearly establish SLC44A1 as an important mediator of choline transport across both the plasma membrane and the mitochondrial membrane.
Advances in diastolic heart failure (2010)

More than 50% of people living with congestive heart failure have diastolic heart failure (DHF). Most of them are older than 70 years, and female. The prevalence of DHF has increased with time. DHF is caused by left ventricular (LV) diastolic dysfunction (DD) which is induced by diastolic dyssynchrony. Cardiac and extracardiac factors play important roles in the development of heart failure (HF) symptoms. The diagnosis of DHF is generally based on typical symptoms and signs of HF, preserved or normal LV ejection fraction, DD and no valvular abnormalities on examination, using noninvasive and invasive methodologies. The outcomes with pharmacological therapy in patients with DHF are frequently neutral in clinical trials, and prognosis still remains poor with a 5-year mortality of 42.3% after hospitalization for HF. Further trials are necessary.
[Corneal wound healing after perforating and non-perforating excimer laser keratectomy. An experimental study]. (1990)

For clinical use of the excimer laser more detailed knowledge of corneal wound healing is necessary. With an ArF excimer laser (193 nm, 750 mJ/cm2, 20 Hz) and a special slit mask system perforating and non-perforating keratectomies were performed in a series of 55 rabbits with a follow-up from one hour to six months post-op. After enucleation the corneas were immediately processed for light microscopy, scanning and transmission electron microscopy and vital staining of the endothelium (trypan blue/alizarin red S). In perforating cuts the endothelial reaction consists of polymegathism, migration, formation of multi-nucleated giant cells, metaplasia-like proliferation and ultimately stable reformation of the cell pattern (1h to 42d). Epithelium fills the anterior wound gap within three days with subsequent regression of the plug. Fibroblastic activity in the adjacent stroma leads to cellular immigration, production of new collageneous lamellae and complete reorganization of the wound cleft (1d to 6m). Nonperforating excisions showed similar healing tendency of stroma and epithelium, but no severe endothelial damage could be detected. Compared with former studies using knife incisions our results do not reveal significant difference regarding epithelial and stromal wound healing events. The encouraging healing tendency of the endothelium--similar to regeneration after ultrasound and Nd:YAG-laser damage--also confirms the applicability of excimer lasers in corneal surgery.
Social Networking for Sharing Cloud Resources (2012)

Cloud computing is a model for enabling convenient, ubiquitous and on-demand network access to a shared pool of configurable computing resources (e.g. storage, applications, and networks) that can be provisioned with minimal management effort. Despite all these benefits, the sharing of resources with other users is a challenge, cloud providers do not commonly facilitate users in sharing their dedicated resources with others. In developing countries it is often too expensive for people to acquire a virtual machine of their own. Users may therefore wish to manage costs and increase computational resource usage by sharing their instances with others. Sadly it is not easy to do this at present. Social networks provide a structure that allows users to interact and share resources (e.g. pictures and videos) on the basis of a trustworthy relationship (e.g. Friendship). This paper highlights a Cloud Resource Bartering model (CRB-model) for sharing user's computational resources through a social network. In our approach we have linked a social network with the computational cloud to create a social cloud (SC) so that users can share their part of the cloud with their social community. A prototype system has been deployed on a social network by using the bartering resource trading mechanism. It is anticipated that this may help users to share their dedicated resources without the need for money changing hands and different communities.
U94 alters FN1 and ANGPTL4 gene expression and inhibits tumorigenesis of prostate cancer cell line PC3. (2005)

The dramatic upregulation of FN 1 and downregulation of ANGPTL 4 genes in PC3 cell line stably expressing U94 implicate up-regulation of FN 1 and downregulation of ANGPTL 4 in anti tumor activity of U94. Further studies are necessary to determine functional roles of differentially expressed genes in U94 recombinant PC3 cell line, and hopefully provide leads to potential therapeutic targets in prostate cancer.
Higher ABCD <sup>2</sup> Score Predicts Patients Most Likely to Have True Transient Ischemic Attack (2008)

Among patients diagnosed by emergency department physicians with TIA, higher ABCD2 score was associated with a greater likelihood that the diagnosis was confirmed on expert review. The predictive power of the ABCD2 model is therefore partially explained by identification of those patients likely to have experienced a true TIA, an important aspect of the score when used by nonneurologists. However, higher ABCD2 scores still remained predictive of 90-day stroke rate in the group of patients judged to have a true TIA by an expert neurologist.
Twenty Security Considerations for Cloud-Supported Internet of Things (2015)

To realize the broad vision of pervasive computing, underpinned by the “Internet of Things” (IoT), it is essential to break down application and technology-based silos and support broad connectivity and data sharing; the cloud being a natural enabler. Work in IoT tends toward the subsystem, often focusing on particular technical concerns or application domains, before offloading data to the cloud. As such, there has been little regard given to the security, privacy, and personal safety risks that arise beyond these subsystems; i.e., from the wide-scale, cross-platform openness that cloud services bring to IoT. In this paper, we focus on security considerations for IoT from the perspectives of cloud tenants, end-users, and cloud providers, in the context of wide-scale IoT proliferation, working across the range of IoT technologies (be they things or entire IoT subsystems). Our contribution is to analyze the current state of cloud-supported IoT to make explicit the security considerations that require further work.
Solubility of silica gel in water (1992)

The solubility of silica gel in distilled water and dilute and alkaline solutions has been investigated. The solubility has been studied as a function of the pH of the gel preparation, pHs, and of the pH of the dissolution media, pHL. A kinetic model for the dissolution process has been developed that permits the determination of the rate constant as well as the equilibrium value of the solubility of the silica gel. The model explains the dependence of the rate constants on the concentration of catalytically active hydroxyl ions as an adsorption of these ions on the silica gel surface. The solubility of silica gel increases with increasing pHL. The solubility dependence on pHS is influenced both by the specific surface area of the gel and gel time. The structure of the gels is determined by the gel time. High solubilities can be achieved by a large specific surface area and a small gel time.
Record Linkage to Match Customer Names: A Probabilistic Approach (2018)

Consider the following problem: given a database of records indexed by names (e.g., name of companies, restaurants, businesses, or universities) and a new name, determine whether the new name is in the database, and if so, which record it refers to. This problem is an instance of record linkage problem and is a challenging problem because people do not consistently use the official name, but use abbreviations, synonyms, different order of terms, different spelling of terms, short form of terms, and the name can contain typos or spacing issues. We provide a probabilistic model using relational logistic regression to find the probability of each record in the database being the desired record for a given query and find the best record(s) with respect to the probabilities. Building on term-matching and translational approaches for search, our model addresses many of the aforementioned challenges and provides good results when existing baselines fail. Using the probabilities outputted by the model, we can automate the search process for a portion of queries whose desired documents get a probability higher than a trust threshold. We evaluate our model on a large real-world dataset from a telecommunications company and compare it to several state-of-the-art baselines. The obtained results show that our model is a promising probabilistic model for record linkage for names. We also test if the knowledge learned by our model on one domain can be effectively transferred to a new domain. For this purpose, we test our model on an unseen test set from the business names of the secondString dataset. Promising results show that our model can be effectively applied to unseen datasets. Finally, we study the sensitivity of our model to the statistics of datasets.
Mass Spectrometry Based Ultrasensitive DNA Methylation Profiling Using Target Fragmentation Assay (2015)

Efficient tools for profiling DNA methylation in specific genes are essential for epigenetics and clinical diagnostics. Current DNA methylation profiling techniques have been limited by inconvenient implementation, requirements of specific reagents, and inferior accuracy in quantifying methylation degree. We develop a novel mass spectrometry method, target fragmentation assay (TFA), which enable to profile methylation in specific sequences. This method combines selective capture of DNA target from restricted cleavage of genomic DNA using magnetic separation with MS detection of the nonenzymatic hydrolysates of target DNA. This method is shown to be highly sensitive with a detection limit as low as 0.056 amol, allowing direct profiling of methylation using genome DNA without preamplification. Moreover, this method offers a unique advantage in accurately determining DNA methylation level. The clinical applicability was demonstrated by DNA methylation analysis using prostate tissue samples, implying the potential of this method as a useful tool for DNA methylation profiling in early detection of related diseases.
Ir Spectra of the Oxides and Sulphides of Triarylphosphines and Triarylarsines (1990)

Department of Chemistry, Annamalai University, Annamalainagar-608 002 <em>Manuscript received 10 May 1988, revised 29 December 1989, accepted 1 January 1990</em> Ir Spectra of the Oxides and Sulphides of Triarylphosphines and Triarylarsines <br>
Secure in-band update of trusted certificates (2003)

The certificate authority (CA) is the central trust point in a public key infrastructure (PKI). Great care should be taken by users when they make a decision to trust a CA. Unfortunately, the average user will rely on the software to provide an appropriate security warning when something has gone wrong and therefore may not give much thought to the decision when performing such a security operation. The updating of a CA certificate is an issue that needs to be accomplished in a secure manner with little or no intervention by a user. Techniques are now in use that can allow for update of a CA's certificate. The Secure Electronic Transaction's (SET) root certificate update method is just one example, but in a specialized case. This paper discusses a practical solution that potentially any CA could use to provide a secure in-band update of a CA's X.509 v3 certificate into a user's personal security environment (PSE). A method is also discussed that Java programmers can use for update of self-signed X.509 v1 personal certificates in Java keystores as well.
Electronic Flight Bag (EFB) policy &amp; guidance information, paper #263 (2011)

Presents a collection of slides covering the following topics: EFB AC 120-76A harmonization; TGL 36; AMC 20-EFB; EFB Class 2 system; EFB Class 3 system; aircraft certification type A & B software applications; EFB hardware connectivity; EFB data connectivity; aircraft power system; aircraft data buses; electronic displays; EFB NextGen avionics; surface traffic and runway occupancy; and EFB security policy.
The Temperature-Phased Anaerobic Biofilter Process (1994)

The “temperature-phased anaerobic biofilter” or TPAB process (U.S. Patent pending), is a new high-rate anaerobic treatment system that includes a thermophilic (56°C) biofilter connected in series with a mesophilic (35°C) biofilter providing for two-temperature, two-phase treatment. Three TPAB systems of different thermophilic:mesophilic reactor size ratios were operated at system HRTs of 24 hrs, 36 hrs, and 48 hrs to characterize performance and to determine if an optimum size ratio exists between the thermophilic and mesophilic phases. The three TPAB systems achieved SCOD reductions in excess of 97% and TCOD reductions in excess of 90% for a synthetic milk substrate over a range of system COD loadings from 2 g COD/L/day to 16 g COD/L/day. There was little difference in performance between the three TPAB systems based on COD reduction and methane production. The 1:7 ratio of thermophilic:mesophilic phase TPAB system performed as well as the 1:3 and 1:1 size ratio TPAB systems. In applications of the process, a relatively small thermophilic first-phase can be used without sacrificing overall two-phase system performance. The TPAB process is a promising new anaerobic treatment technology with the ability to achieve higher efficiencies of organic removals than is generally possible for single-stage anaerobic filter systems operated at equivalent HRTs and organic loadings.
Blood cell classification utilizing hydrodynamic filtration (2010)

Abstract Selection or concentration of small particles such as specific cells or microbes is a very important technique in various fields. We have developed a method for separating and concentrating particles or cells according to size, termed hydrodynamic filtration (HDF), using microfluidic devices. In this study, we tried to separate and concentrate blood cells by simply introducing cell suspension into microfluidic devices, without using complicated operations and external devices. © 2010 Wiley Periodicals, Inc. Electron Comm Jpn, 94(1): 1–6, 2011; Published online in Wiley Online Library ( wileyonlinelibrary.com ). DOI 10.1002/ecj.10281
The study of slow coherent molecular motion by pulsed nuclear magnetic resonance (1969)

The effect of coherent molecular motion, e.g. flow, on pulsed nuclear magnetic resonance experiments is investigated theoretically. New pulse sequences are proposed which enable coherent velocities of the order of 10-3 cm s-1 to be measured. Equations are derived for spin-echo amplitudes in the new pulse sequence taking into account both random (self-diffusion) and coherent (flow) motion. Experiments are reported which confirm the predictions of the equations and some possible applications are discussed.
Plasma concentrations of α‐MSH, AgRP and leptin in lean and obese men and their relationship to differing states of energy balance perturbation (2004)

We show a difference in alpha-MSH and AgRP in lean and obese subjects that correlates closely with body fat at baseline. We demonstrate an increase in plasma AgRP during a 6-day fast in lean individuals that is coincident with a decrease in plasma leptin. This increase in AgRP was not due to weight loss per se as there was no change in AgRP as a result of the same weight loss in the VLCD intervention in lean individuals. The source of the increase in plasma AgRP and its physiological function in the periphery remains to be elucidated but we suggest that the dynamics of the change in plasma leptin may determine the elevation in fasting plasma AgRP in lean subjects.
Predicting Radiological Panel Opinions Using a Panel of Machine Learning Classifiers (2009)

This paper uses an ensemble of classifiers and active learning strategies to predict radiologists’ assessment of the nodules of the Lung Image Database Consortium (LIDC). In particular, the paper presents machine learning classifiers that model agreement among ratings in seven semantic characteristics: spiculation, lobulation, texture, sphericity, margin, subtlety, and malignancy. The ensemble of classifiers (which can be considered as a computer panel of experts) uses 64 image features of the nodules across four categories (shape, intensity, texture, and size) to predict semantic characteristics. The active learning begins the training phase with nodules on which radiologists’ semantic ratings agree, and incrementally learns how to classify nodules on which the radiologists do not agree. Using our proposed approach, the classification accuracy of the ensemble of classifiers is higher than the accuracy of a single classifier. In the long run, our proposed approach can be used to increase consistency among radiological interpretations by providing physicians a “second read”.
The Heat Shock Protein 70 Family of Chaperones Regulates All Phases of the Enterovirus A71 Life Cycle (2020)

Enterovirus A71 (EV-A71) is one of the major etiologic agents causing hand, foot, and mouth disease (HFMD) in children and occasionally causes severe neurological diseases or even death. EV-A71 replicates rapidly in host cells. For a successful infection, viruses produce large quantities of viral proteins in a short period, which requires cellular chaperone proteins for viral protein folding and viral particle assembly. In this study, we explored the roles of the heat shock protein 70 (HSP70) chaperone subnetwork in the EV-A71 life cycle. Our results revealed that EV-A71 exploits multiple HSP70s at each step of the viral life cycle, i.e., viral entry, translation, replication, assembly and release, and that each HSP70 typically functions in several stages of the life cycle. For example, the HSP70 isoforms HSPA1, HSPA8, and HSPA9 are required for viral entry and the translational steps of the infection. HSPA8 and HSPA9 may facilitate folding and stabilize viral proteins 3D and 2C, respectively, thus contributing to the formation of a replication complex. HSPA8 and HSPA9 also promote viral particle assembly, whereas HSPA1 and HSPA8 are involved in viral particle release. Because of the importance of various HSP70s at distinct steps of the viral life cycle, an allosteric inhibitor, JG40, which targets all HSP70s, significantly blocks EV-A71 infection. JG40 also blocks the replication of several other enteroviruses, such as coxsackievirus (CV) A16, CVB1, CVB3, and echovirus 11. Thus, targeting HSP70s may be a means of providing broad-spectrum antiviral therapy.