gebhart/patrepeval huggingface dataset:
Regulation of Pacing Rate by Variations of Mixed Venous Oxygen Saturation (1984)

Right ventricular oxygen saturation (SO2) may be an ideal sensor for determining the rate of an implanted pacemaker. In order to prove this hypothesis, the obtained signals were optimally analyzed; determinations of SO2 at rest and during exercise were made in healthy volunteers and in patients with pacemakers; and an algorithm was developed for varying pacing rate as a function of measured SO2. The results suggest that this method may be applicable to the long-term implantee.
Loss of heterozygosity detected in formalin-fixed, paraffin-embedded tissue of colorectal carcinoma using a microsatellite located within the deleted in colorectal carcinoma gene. (1993)

We determined loss of heterozygosity from formalin-fixed, paraffin-embedded tissue of colorectal carcinoma using microsatellite polymorphism. The polymorphism was assayed based on DNA amplification by the polymerase chain reaction (PCR). The PCR-analyzed microsatellite method was applied to assay degraded DNA extracted from paraffin-embedded blocks with adenocarcinoma of colon. The DNA from 26 tumors as well as their corresponding normal tissue samples were successfully amplified using a dinucleotide microsatellite located within an intron of the deleted in colorectal carcinoma gene. Allele losses on this marker were detected in 33% of informative colorectal carcinomas. This study demonstrates that microsatellites provide a powerful set of DNA markers for loss of heterozygosity on archival specimens.
Rotavirus nonstructural glycoprotein NSP4 alters plasma membrane permeability in mammalian cells (1997)

The endoplasmic reticulum-localized transmembrane glycoprotein NSP4 of rotavirus is a key protein involved in rotavirus cytopathology. We have used a dual-recombinant vaccinia virus system to express NSP4 in monkey kidney epithelial cells at a level comparable to that observed during rotavirus infection. Expression of NSP4 results in loss of plasma membrane integrity, which can be demonstrated by release of both 51Cr and lactate dehydrogenase into the medium. The cytotoxic behavior of NSP4 is dose dependent, and morphological analysis reveals gross changes to cell ultrastructure, indicative of cell death. Thus, intracellular expression of a single rotavirus protein which localizes to the endoplasmic reticulum membrane has profound effects on the stability of the plasma membrane and cell viability. Analysis of NSP4 deletion mutants indicates that a membrane-proximal region located within the cytoplasmic domain may mediate cytotoxicity.
Active acceleration compensation using a Stewart-platform on a mobile robot (2002)

If an object is transported on a mobile platform, all accelerations of the mobile platform affect the object. This is of course undesirable, since accelerations can move or even damage the object. Stewart-platforms are mostly used for simulation, where the platform generates accelerations that increase the simulation's quality. Vice versa, it's possible to use a Stewart-platform mounted on a mobile platform to compensate the unwanted accelerations by generating a tilt. The necessary movement of the platform is calculated by a washout-filter. Applications of this combination include the transport of liquids in open boxes and medical transports, where the patients must not be affected by any acceleration.
The Effect of Surfactants on the Diameter and Morphology of Electrospun Ultrafine Nanofiber (2014)

Different surfactants are introduced to study the diameter and morphology transformation characteristics of electrospun nanofiber. Surfactants increase the net charge density and instability motion of charged jet. The instability motion provides a good way to stretch the charged jets into finer ones, by which the beaded structures are also prevented. Ultrafine nanofiber with average diameter less than 65 nm can be fabricated. The nanofiber diameter decreases with the increase of surfactant concentration in polymer solution. The nanofibers with anionic surfactant sodium dodecyl sulfate (SDS) have the smallest diameter. The cationic surfactant hexadecyl trimethyl ammonium bromide (HTAB) plays the best role to prevent the formation of beaded structures in nanofibers, and helps to increase the uniformity of electrospun nanofiber. The effects of surfactants on the nanofiber diameter and morphology have been studied, which would promote the industrial application of ultrafine polymeric nanofibers.
Identification of redundant delay faults (1994)

Various defects during fabrication have been shown in the literature to introduce delay faults in logic circuits. This paper analyzes the effects of these defects on the normal operation of logic circuits with the goal of developing an appropriate model for these faults. Single and multiple delay faults in this model are analyzed to determine if they are redundant with respect to the normal operation of the logic circuit. The relationships between delay redundancies and stuck-at redundancies are discussed. The redundancy identification techniques are applied to various benchmarks circuits and experimental data are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
On Techniques for Angle Compensation in Nonideal Iris Recognition (2007)

The popularity of the iris biometric has grown considerably over the past two to three years. Most research has been focused on the development of new iris processing and recognition algorithms for frontal view iris images. However, a few challenging directions in iris research have been identified, including processing of a nonideal iris and iris at a distance. In this paper, we describe two nonideal iris recognition systems and analyze their performance. The word "nonideal" is used in the sense of compensating for off-angle occluded iris images. The system is designed to process nonideal iris images in two steps: 1) compensation for off-angle gaze direction and 2) processing and encoding of the rotated iris image. Two approaches are presented to account for angular variations in the iris images. In the first approach, we use Daugman's integrodifferential operator as an objective function to estimate the gaze direction. After the angle is estimated, the off-angle iris image undergoes geometric transformations involving the estimated angle and is further processed as if it were a frontal view image. The encoding technique developed for a frontal image is based on the application of the global independent component analysis. The second approach uses an angular deformation calibration model. The angular deformations are modeled, and calibration parameters are calculated. The proposed method consists of a closed-form solution, followed by an iterative optimization procedure. The images are projected on the plane closest to the base calibrated plane. Biorthogonal wavelets are used for encoding to perform iris recognition. We use a special dataset of the off-angle iris images to quantify the performance of the designed systems. A series of receiver operating characteristics demonstrate various effects on the performance of the nonideal-iris-based recognition system.
The potential role of lysosomes in tissue distribution of weak bases (1988)

The potential importance of lysosomes as a site of accumulation of weak bases in tissues is discussed. A simple mathematical treatment predicts the quantitative significance of lysosomal trapping for monoacidic and diacidic weak bases. The features which are characteristics of lysosomal trapping are discussed, particularly in comparison with active transport and intracellular binding mechanisms. These features include: linear accumulation at low concentrations; nonlinearity at higher concentrations; dependence on structural integrity of tissue; energy dependence and competition with other weak bases. Subcellular distribution studies have previously shown that weak bases accumulate extensively in membranes; however, the dependence of accumulation on the structural integrity of tissue suggests that this is not the only significant mechanism of accumulation. The results of a range of studies of tissue distribution of weak bases are discussed to illustrate that these findings are consistent with accumulation in lung and liver being attributable to a combination of lysosomal trapping and accumulation in membranes whereas, in muscle, accumulation in membranes is the predominant mechanism of accumulation. The possible pharmacokinetic significance of lysosomal trapping of weak bases is also discussed.
Functional Analysis of a Cell Cycle–Associated, Tumor-Suppressive Gene, <i>Protein Tyrosine Phosphatase Receptor Type G</i>, in Nasopharyngeal Carcinoma (2008)

Functional studies to identify the potential role of a chromosome 3p14-21 gene, protein tyrosine phosphatase receptor type G (PTPRG), were performed. PTPRG was identified as a candidate tumor suppressor gene (TSG) in nasopharyngeal carcinoma (NPC) by differential gene profiling of tumorigenic and nontumorigenic NPC chromosome 3 microcell hybrids (MCH). Down-regulation of this gene was found in tumor segregants when compared with their corresponding tumor-suppressive MCHs, as well as in NPC cell lines and tumor biopsies. Promoter hypermethylation and loss of heterozygosity were found to be important mechanisms contributing to PTPRG silencing. PTPRG overexpression in NPC cell lines induces growth suppression and reduced anchorage-independent growth in vitro. This is the first study to use a tetracycline-responsive vector expression system to study PTPRG stable transfectants. Results indicate its ability to induce significant tumor growth suppression in nude mice under conditions activating transgene expression. These studies now provide functional evidence indicating critical interactions of PTPRG in the extracellular matrix milieu induce cell arrest and changes in cell cycle status. This is associated with inhibition of pRB phosphorylation through down-regulation of cyclin D1. These novel findings enhance our current understanding of how PTPRG may contribute to tumorigenesis.
dGNaC1, a gonad-specific amiloride-sensitive Na+ channel (1998)

Page 9427, Fig. 3: The quality of reproduction was not satisfactory. An improved version is shown below.
Prognostic Significance of Epithelial-Mesenchymal and Mesenchymal-Epithelial Transition Protein Expression in Non–Small Cell Lung Cancer (2008)

Because up-regulation is frequently observed in the stromal and epithelial tumor compartment, EMT-MET indicator proteins may be integrated in progression models of NSCLC.
A test port for interfacing and debugging ARM9 processors implemented in FPGA (2012)

This paper presents an FPGA implementation of a test port for interfacing and debugging ARM9 processors. The system included a communication interface for debugging the processor, together with the JTAG-based module that granted debugging capability to the selected ARM9 core. Also included was an application software debugger that readily shows the comparison of expected and gathered results from the processor core. The debugging system for the selected ARM9 processor was successfully implemented in a Virtex 5 FPGA development board and was tested using the supported data processing instructions. The latency measured was 0.3 ms per instruction for a baud rate of 4800.
U-city portal for smart ubiquitous middleware (2010)

Ubiquitous-city (u-city) middleware is essential to provide a variety of integrated and intelligent u-city services to u-city applications. Another essential element to u-city is the u-city portal if the u-city offers its services through World Wide Web. The u-city portal should well cooperate with the u-city middleware as well as support web-based applications efficiently. Yet, there is no reported research on a u-city portal based on a u-city middleware. We introduce u-city portal in this paper. This paper explains the mechanism, the interface to the u-city applications, the interface to the u-city middleware and how to cooperate with the u-city middleware to give a variety of u-city services to applications.
Integrating discrete-event simulation with statistical process control charts for transitions in a manufacturing environment (1999)

We present a model that integrates real-time process control charting with simulation modeling to illustrate the effects and benefits of SPC charts for quality improvement efforts.The integrated model is particularly significant in addressing transition issues arising from changes in the input material.A case study based on a medical manufacturing industry process is used to illustrate the approach.
Coupled Multielectrode Array Systems and Sensors for Real-Time Corrosion Monitoring - A Review (2006)

Abstract This paper presents a review of multielectrode array systems and sensors for electrochemical studies and corrosion monitoring. Uncoupled multielectrode arrays [also called wire beam electrodes (WBEs)] for corrosion studies were reported in 1991. Coupled multielectrode arrays were first reported in 1996 for studying the spatiotemporal electrochemical behavior and corrosion processes, and in 1997 for mapping localized corrosion. More recently, coupled multielectrode array sensors (CMASs) have been used for real-time measurement of localized corrosion rates. The various application examples for the CMAS probes, including quantitative localized corrosion monitoring in aqueous solutions, wet gases, oil/water mixtures, salt deposits, biodeposits, soil, concrete, and undercoatings were reviewed. Some of the limitations of the multielectrode array systems are discussed.
ALIPHATIC NITRO KETONES (1955)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTALIPHATIC NITRO KETONESCHARLES D. HURD and MAY E. NILSONCite this: J. Org. Chem. 1955, 20, 7, 927–936Publication Date (Print):July 1, 1955Publication History Published online1 May 2002Published inissue 1 July 1955https://pubs.acs.org/doi/10.1021/jo01125a018https://doi.org/10.1021/jo01125a018research-articleACS PublicationsRequest reuse permissionsArticle Views824Altmetric-Citations57LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Control of the Morphology and Particle Size of Boehmite Nanoparticles Synthesized under Hydrothermal Conditions (2007)

The spontaneous nucleation under hydrothermal conditions often leads to aggregation of crystallizing particles, which is an undesired phenomenon when the goal is the preparation of nanocrystals with narrow particle size distribution. The present paper reports on the synthesis of boehmite nanocrystals under hydrothermal conditions. An aqueous aluminum chloride salt solution was first prepared, and the pH was increased to 11 using a 5 M sodium hydroxide solution. The hydrothermal treatment was performed at 160 degrees C for different periods of time. The system yielded relatively small (15-40 nm) boehmite crystallites aggregated into larger (160 nm) particles. To avoid the aggregation, a biocompatible polymer, sodium polyacrylate (NaPa) 2100, was employed as a size-/morphology-controlling agent. Thus, stable colloidal suspensions of rounded boehmite nanoparticles having a size between 15 and 40 nm were obtained at 160 degrees C for 24 h. Further, the effect of synthesis time on the morphological features of boehmite synthesized in such a NaPa-containing system was investigated. The increase of the synthesis time from 24 to 168 h resulted in the formation of very long boehmite fibers (1000-2000 nm) with an average diameter of about 10 nm. The boehmite samples were characterized by XRD, DLS, TEM, IR, N2 adsorption, and zeta potential measurements. The colloidal stability of the obtained suspension was also studied.
Distinct mechanisms of platelet aggregation as a consequence of different shearing flow conditions. (1998)

Platelet aggregation contributes to arresting bleeding at wound sites, but may cause occlusion of atherosclerotic vessels, thus curtailing blood flow to vital organs. According to current dogma, the integrin alphaIIbbeta3 plays an exclusive role in linking platelets to one another through interactions with fibrinogen or vWf. We demonstrate here that, depending on shearing flow conditions, this process may require vWf binding to glycoprotein Ibalpha, even when alphaIIbbeta3 is competent to bind adhesive ligands. Platelet activation induced solely by high shear stress is initiated by glycoprotein Ibalpha interaction with vWf, but results in aggregation only if the latter can bind concurrently to alphaIIbbeta3. In contrast, platelets exposed to high shear rate after activation by exogenous agonists such as ADP and epinephrine can aggregate when fibrinogen is the alphaIIbbeta3 adhesive ligand, yet only if vWf binding to glycoprotein Ibalpha can also occur. Thus, the latter interaction appears to provide a bond with biomechanical properties necessary to overcome the effects of high shear rate and initiate interplatelet cohesion. These findings highlight the distinct function of two adhesive receptors mediating platelet aggregation under varying fluid dynamic conditions, and modify the current interpretation of a crucial event in hemostasis and thrombosis.
Crystallographic Realization of the Mathematically Predicted Densest All‐Pentagon Packing Lattice by <i>C</i><sub>5</sub>‐Symmetric “Sticky” Fluoropentamers (2011)

Regular pentagonal adhesive tiles were obtained by designing a cyclic fluoropentamer with an internal CF⋅⋅⋅HN H-bonded network and “sticky” edges that can glue the molecules together through intermolecular CArH⋅⋅⋅OC H bonds. In the crystal they form the mathematically predicted densest all-pentagon 2D lattice with a packing density of 0.921 (see picture). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Assessment of the Progress of the Back-Pain Patient (1982)

Fifteen subjective variables reflecting the severity of back pain, the circumstances exacerbating symptoms, and the impact of the problem on life style were scored on Visual Analogue Scales. It was possible to combine the results from these assessments to provide a global subjective index. Repeated measurements by the same observer showed a high degree of reproducibility, but when performed by separate observers discrepancies arose in certain questions. By improving certain questions and standardizing their presentation to the patient, a considerable improvement in the correlation of results between observers was obtained. Objective assessments of spinal motion and straight leg raising and a global objective index showed a high degree of intraobserver reproducibility. This technique was applied to a study of relief of back pain by lumbar corsets when it was found that there was significantly greater relief of back pain by a corset with a lumbar support than one without a spinal support. We conclude that the emphasis in assessing the progress of the back-pain patient must be on the subjective parameters, and the technique developed offers a useful method for reliably assessing patients and following their progress.
Interventional MRA and intravascular imaging (2000)

Several attributes make magnetic resonance imaging (MRI) attractive for guidance of intravascular therapeutic procedures, including high soft tissue contrast, imaging in arbitrary oblique planes, lack of ionizing radiation, and the ability to provide functional information, such as flow velocity or flow volume per unit time, in conjunction with morphologic information. For MR guidance of vascular interventions to be safe, the interventionalist must be able to visualize catheters and guidewires relative to the vascular system and surrounding tissues. A number of approaches for rendering instruments visible in an MR environment have been developed, including both passive and active techniques. Passive techniques depend on contrast agents or susceptibility artifacts that enhance the appearance of the catheter in the image itself, whereas active techniques rely on supplemental hardware built into the catheter, such as a radiofrequency (RF) coil. Additionally, the ability to introduce an RF coil mounted on a catheter presents the opportunity to obtain high-resolution images of the vessel wall. These images can provide the capability to distinguish and identify various plaque components. The additional capabilities of MRI could potentially open up new applications within the purview of vascular interventions beyond those currently performed under X-ray fluoroscopic guidance.
The Oct-1 POU-Specific Domain Can Stimulate Small Nuclear RNA Gene Transcription by Stabilizing the Basal Transcription Complex SNAP<sub>c</sub> (1996)

The RNA polymerase II and III human small nuclear RNA promoters have a common basal element, the proximal sequence element, which binds the TATA box-binding protein-containing complex SNAPc. They also contain an enhancer characterized by a highly conserved octamer sequence, which constitutes a binding site for the broadly expressed POU domain transcription factor Oct-1. The POU domain is a bipartite DNA-binding domain consisting of a POU-homeo (POUH) domain and a POU-specific (POUs) domain joined by a flexible linker. Here, we show that the Oct-1 POU domain but not the related Pit-1 POU domain can facilitate the binding of SNAPc to the proximal sequence element, and activate transcription. The effect is probably mediated by protein-protein contacts, and 1 of 30 amino acid differences between the Oct-1 and Pit-1 POUs domains is the key determinant for the differential interaction with SNAPc and the ability to activate transcription. These results show that a function that is the hallmark of activation domains, namely, recruitment of a basal transcription complex resulting in activation of transcription, can be performed by a DNA-binding domain. In this case, subtle changes between activator DNA-binding domains, as subtle as a single amino acid difference, can profoundly affect interaction with the basal transcription machinery.
The antisite Lu<sub>Al</sub> defect‐related trap in Lu<sub>3</sub>Al<sub>5</sub>O<sub>12</sub>:Ce single crystal (2005)

Abstract Absorption, radioluminescence and thermoluminescence spectra were measured for a set of Lu 3 Al 5 O 12 :Ce samples consisting of a bulk single crystal and Liquid Phase Epitaxy‐grown films prepared from the same raw materials. The triple peak structure within 120–200 K distinguished in thermolu‐ minescence glow curves of the bulk crystals was ascribed to an electron trap arising due to the Lu Al antisite defect. The depth of the trap associated with the dominant peak at 142 K was evaluated using the initial rise method. (© 2005 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)