gebhart/patrepeval huggingface dataset:
Centralized and Distributed Anonymization for High-Dimensional Healthcare Data (2010)

Sharing healthcare data has become a vital requirement in healthcare system management; however, inappropriate sharing and usage of healthcare data could threaten patients’ privacy. In this article, we study the privacy concerns of sharing patient information between the Hong Kong Red Cross Blood Transfusion Service (BTS) and the public hospitals. We generalize their information and privacy requirements to the problems of centralized anonymization and distributed anonymization , and identify the major challenges that make traditional data anonymization methods not applicable. Furthermore, we propose a new privacy model called LKC-privacy to overcome the challenges and present two anonymization algorithms to achieve LKC-privacy in both the centralized and the distributed scenarios. Experiments on real-life data demonstrate that our anonymization algorithms can effectively retain the essential information in anonymous data for data analysis and is scalable for anonymizing large datasets.
Effect of Material Type and Size Distribution on Performance of Loss/Seepage Control Material (2002)

Abstract Circulation losses have always been a serious and expensive problem to drilling industry. Even with the best drilling practices circulation losses do occur. In order to reduce such losses to acceptable level fluid Loss Control Material (LCM) or Seepage Control Material (SCM) is used. The objectives of this study have been to evaluate and compare the performance of different LCM/SCM and determine the effect of size distribution on their performance. Twenty-four different LCM/SCM samples made of various materials and blends of material having different size distributions were tested with three different types of mud. The three mud types used were water base mud, regular oil base mud, and environmentally safe oil base (Synvert) mud. With each mud three tests were conducted, one with the base mud and two with LCM/SCM concentrations of 5 and 10 lbs/bbl. The experiments were conducted in a Permeability Plugging Apparatus (PPA) at a differential pressure of 2500 psi and 250 °F, using ceramic disks. The performance of each LCM/SCM sample was determined based on the amount of spurt loss and total fluid loss of the mud according to the recommended procedure for PPA. The experiments show that amount of fluid loss depends on the mud type, LCM/SCM material, concentration and size distribution. This paper presents details of the experiments, the collected data and the analysis and discussion of the results obtained.
Amyloid Beta Inhibits Olfactory Bulb Activity and the Ability to Smell (2013)

Early olfactory dysfunction has been consistently reported in both Alzheimer's disease (AD) and in transgenic mice that reproduce some features of this disease. In AD transgenic mice, alteration in olfaction has been associated with increased levels of soluble amyloid beta protein (Aβ) as well as with alterations in the oscillatory network activity recorded in the olfactory bulb (OB) and in the piriform cortex. However, since AD is a multifactorial disease and transgenic mice suffer a variety of adaptive changes, it is still unknown if soluble Aβ, by itself, is responsible for OB dysfunction both at electrophysiological and behavioral levels. Thus, here we tested whether or not Aβ directly affects OB network activity in vitro in slices obtained from mice and rats and if it affects olfactory ability in these rodents. Our results show that Aβ decreases, in a concentration- and time-dependent manner, the network activity of OB slices at clinically relevant concentrations (low nM) and in a reversible manner. Moreover, we found that intrabulbar injection of Aβ decreases the olfactory ability of rodents two weeks after application, an effect that is not related to alterations in motor performance or motivation to seek food and that correlates with the presence of Aβ deposits. Our results indicate that Aβ disrupts, at clinically relevant concentrations, the network activity of the OB in vitro and can trigger a disruption in olfaction. These findings open the possibility of exploring the cellular mechanisms involved in early pathological AD as an approach to reduce or halt its progress.
Humanoids Designed to do Work (2001)

NASA began with the challenge of building a robot fo r doing assembly, maintenance, and diagnostic work in the Og environment of space. A robot with human form was then chosen as the best means of achieving that mission. The goal was not to build a machine to look like a human, but rather, to build a system that could do the same work. Robonaut could be inserted into the existing space environment, designed for a population of astronauts, and be able to perform many of the same tasks, with the same tools, and use the same interfaces. Rather than change that world to accommodate the robot, instead Robonaut accepts that it exists for humans, and must conform to it. While it would be easier to build a robot if all the interfaces could be changed, this is not the reality of space at present, where NASA has invested billions of dollars building spacecraft like the Space Shuttle and International Space Station. It is not possible to go back in time, and redesign those systems to accommodate full automation, but a robot can be built that adapts to them. This paper describes that design process, and the res ultant solution, that NASA has named Robonaut.
Studies on Polynucleotides. I. A New and General Method for the Chemical Synthesis of the C<sub>5</sub>″-C<sub>3</sub>″ Internucleotidic Linkage. Syntheses of Deoxyribo-dinucleotides<sup>1</sup> (1958)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudies on Polynucleotides. I. A New and General Method for the Chemical Synthesis of the C5″-C3″ Internucleotidic Linkage. Syntheses of Deoxyribo-dinucleotides1P. T. Gilham and H. G. KhoranaCite this: J. Am. Chem. Soc. 1958, 80, 23, 6212–6222Publication Date (Print):December 1, 1958Publication History Published online1 May 2002Published inissue 1 December 1958https://pubs.acs.org/doi/10.1021/ja01556a016https://doi.org/10.1021/ja01556a016research-articleACS PublicationsRequest reuse permissionsArticle Views1089Altmetric-Citations162LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Effect of Dietary Essential Amino Acid Limitations upon the Susceptibility to <i>Salmonella typhimurium</i> and the Effect Upon Humoral and Cellular Immune Responses in Mice (1981)

We investigated the effects of dietary essential amino acid limitations on the susceptibility of mice to Salmonella typhimurium infections and on humoral and cellular immune (cell-mediated immune) responses of mice. Mice fed synthetic diets limited (significantly less than optimum concentration) in a single essential amino acid (leucine, isoleucine, valine, or lysine) for 3 weeks after they were weaned exhibited significantly enhanced susceptibility to S. typhimurium infection, as evidenced by the higher levels of mortality and spread of the bacterial cells in their livers and spleens compared with mice fed the control diet. Compared with mice fed the control diet, mice fed the diet limited in leucine had a lower ability to clear S. typhimurium cells from the peritoneal cavity 5 min after intraperitoneal injection, whereas mice fed the diet limited in lysine had a greater ability. The in vivo phagocytosis and in vitro bactericidal kinetics against S. typhimurium cells by peritoneal macrophages were not significantly different in the control group and the groups of mice fed experimental diets. Certain experimental groups exhibited significantly lower resistance and antibody response against S. typhimurium SL3770 on day 5 after immunization with heat-killed S. typhimurium SL3770. On day 8 after immunization, the levels of serum antibody against S. typhimurium in the mice fed the experimental diets were comparable to the levels in mice fed the control diet. However, the levels of serum transferrin and complement C3 were significantly lower in mice fed certain experimental diets. The cellular immune capacities of mice fed any of the experimental diets were not impaired compared with the capacities of mice fed the control diet, as measured by spleen cell responsiveness to phytohemagglutinin and the ability to clear infecting Listeria monocytogenes cells from livers and spleens.
Survival of viral pathogens in animal feed ingredients under transboundary shipping models (2018)

The goal of this study was to evaluate survival of important viral pathogens of livestock in animal feed ingredients imported daily into the United States under simulated transboundary conditions. Eleven viruses were selected based on global significance and impact to the livestock industry, including Foot and Mouth Disease Virus (FMDV), Classical Swine Fever Virus (CSFV), African Swine Fever Virus (ASFV), Influenza A Virus of Swine (IAV-S), Pseudorabies virus (PRV), Nipah Virus (NiV), Porcine Reproductive and Respiratory Syndrome Virus (PRRSV), Swine Vesicular Disease Virus (SVDV), Vesicular Stomatitis Virus (VSV), Porcine Circovirus Type 2 (PCV2) and Vesicular Exanthema of Swine Virus (VESV). Surrogate viruses with similar genetic and physical properties were used for 6 viruses. Surrogates belonged to the same virus families as target pathogens, and included Senecavirus A (SVA) for FMDV, Bovine Viral Diarrhea Virus (BVDV) for CSFV, Bovine Herpesvirus Type 1 (BHV-1) for PRV, Canine Distemper Virus (CDV) for NiV, Porcine Sapelovirus (PSV) for SVDV and Feline Calicivirus (FCV) for VESV. For the remaining target viruses, actual pathogens were used. Virus survival was evaluated using Trans-Pacific or Trans-Atlantic transboundary models involving representative feed ingredients, transport times and environmental conditions, with samples tested by PCR, VI and/or swine bioassay. SVA (representing FMDV), FCV (representing VESV), BHV-1 (representing PRV), PRRSV, PSV (representing SVDV), ASFV and PCV2 maintained infectivity during transport, while BVDV (representing CSFV), VSV, CDV (representing NiV) and IAV-S did not. Notably, more viruses survived in conventional soybean meal, lysine hydrochloride, choline chloride, vitamin D and pork sausage casings. These results support published data on transboundary risk of PEDV in feed, demonstrate survival of certain viruses in specific feed ingredients ("high-risk combinations") under conditions simulating transport between continents and provide further evidence that contaminated feed ingredients may represent a risk for transport of pathogens at domestic and global levels.
Polyphenolic Antioxidants from the Fruits of<i>Chrysophyllum cainito</i>L. (Star Apple) (2002)

Chrysophyllum cainito L. (Sapotaceae), known commonly as star apple or caimito, is a tropical tree that bears edible fruits. The fruits are grown commercially in certain tropical and subtropical areas, such as southern Florida. In this study, the fresh fruits were extracted with methanol and partitioned with hexane and ethyl acetate sequentially. The ethyl acetate soluble fraction displayed high antioxidant activity in the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay (IC50 = 22 microg/mL). Activity-guided fractionation of the ethyl acetate soluble fraction was performed to identify the antioxidant constituents. Nine known polyphenolic antioxidants, (+)-catechin (1), (-)-epicatechin (2), (+)-gallocatechin (3), (-)-epigallocatechin (4), quercetin (5), quercitrin (6), isoquercitrin (7), myricitrin (8), and gallic acid, have been identified from the fruits. Of these nine antioxidants, 2 is present in the highest concentration in star apple fruits (7.3 mg/kg fresh weight), and 5 showed the highest antioxidant activity (IC50 = 40 microM) in the DPPH assay.
Ringing Suppression in a Controller Area Network With Flexible Data Rate Using Impedance Switching and a Limiter (2019)

The ringing and the resulting asymmetry in the propagation delay are the main causes of bandwidth degradation and communication errors in a controller area network (CAN) with flexible data rate. Therefore, in this paper, the mechanism of ringing is analyzed, and the ringing suppression circuit is proposed based on the analysis. The proposed circuit includes an impedance matching resistor and a forward-biased diode for terminating the repetition of reflections and limiting the magnitude of the ringing. These components are temporarily connected by operating a switch that is controlled by the TxD signal of a CAN controller so that the ringing suppression circuit only engages when necessary and at the correct time. The performance of the ringing suppression circuit is verified by experiments. The experimental results show that the proposed circuit keeps the ringing adequately suppressed and the good symmetry in the propagation delay across the physical bus is possessed.
High microvascular blood volume is associated with high glucose uptake and tumor angiogenesis in human gliomas. (2000)

The purpose of this investigation was to elucidate the association between microvascular blood volume and glucose uptake and to link these measures with tumor angiogenesis. We demonstrate a regionally specific correlation between tumor relative microvascular blood volume (CBV), determined in vivo with functional magnetic resonance imaging techniques, and tumor glucose uptake determined with fluorodeoxyglucose positron emission tomography. Regions of maximum glucose uptake were well matched with maximum CBV across all patients (n = 21; r = 0.572; P = 0.023). High-grade gliomas showed significantly elevated CBV and glucose uptake compared with low-grade gliomas, (P = 0.009 and 0.008, respectively). Correlations between CBV and glucose uptake were then determined on a voxel-by-voxel basis within each patient's glioma. Correlation indices varied widely, but in 16 of 21 cases of human glioma, CBV and glucose uptake were correlated (r > 0.150). These measures were well correlated in all cases when comparing healthy brain tissue in these same patients. Tumor vascularity, as determined immunohistochemically and morphometrically on clinical samples, revealed statistically significant relationships with functional imaging characteristics in vivo. Regional heterogeneities in glucose uptake were well matched with functional magnetic resonance imaging CBV maps. Our findings support the concept that there is an association of microvascular density and tumor energy metabolism in most human gliomas. In addition, the findings are likely to have important clinical applications in the initial evaluation, treatment, and longitudinal monitoring of patients with malignant gliomas.
Mutations of the DPC4/Smad4 gene in biliary tract carcinoma. (1998)

A candidate tumor suppressor gene, DPC4, located at 18q21.1, has recently been shown to be inactivated in half of pancreatic adenocarcinomas. The close developmental relationship of the pancreas and biliary tract prompted us to determine the role of DPC4 in the multistep carcinogenesis of biliary tract carcinoma. A search for mutations in the genomic sequence of the highly conserved COOH-terminal domain of DPC4 (exons 8-11) was performed by single-strand conformational polymorphism analysis. Five of 32 (16%) primary biliary tract carcinomas had point mutations in the DPC4 sequence. Interestingly, inactivation of DPC4 was especially common in carcinomas originating from the common bile duct (four of eight specimens analyzed), suggesting an important role for DPC4 in the development of this subtype of biliary tract tumor.
Neural regulation of cancer: from mechanobiology to inflammation (2016)

Despite recent progress in cancer research, the exact nature of malignant transformation and its progression is still not fully understood. Particularly metastasis, which accounts for most cancer death, is a very complex process, and new treatment strategies require a more comprehensive understanding of underlying regulatory mechanisms. Recently, the sympathetic nervous system (SNS) has been implicated in cancer progression and beta-blockers have been identified as a novel strategy to limit metastasis. This review discusses evidence that SNS signaling regulates metastasis by modulating the physical characteristics of tumor cells, tumor-associated immune cells and the extracellular matrix (ECM). Altered mechanotype is an emerging hallmark of cancer cells that is linked to invasive phenotype and treatment resistance. Mechanotype also influences crosstalk between tumor cells and their environment, and may thus have a critical role in cancer progression. First, we discuss how neural signaling regulates metastasis and how SNS signaling regulates both biochemical and mechanical properties of tumor cells, immune cells and the ECM. We then review our current knowledge of the mechanobiology of cancer with a focus on metastasis. Next, we discuss links between SNS activity and tumor-associated inflammation, the mechanical properties of immune cells, and how the physical properties of the ECM regulate cancer and metastasis. Finally, we discuss the potential for clinical translation of our knowledge of cancer mechanobiology to improve diagnosis and treatment.
Tsunami waveform inversion for sea surface displacement following the 2011 Tohoku earthquake: Importance of dispersion and source kinematics (2015)

Abstract This paper considers the importance of model parameterization, including dispersion, source kinematics, and source discretization, in tsunami source inversion. We implement single and multiple time window methods for dispersive and nondispersive wave propagation to estimate source models for the tsunami generated by the 2011 Tohoku‐Oki earthquake. Our source model is described by sea surface displacement instead of fault slip, since sea surface displacement accounts for various tsunami generation mechanisms in addition to fault slip. The results show that tsunami source models can strongly depend on such model choices, particularly when high‐quality, open‐ocean tsunami waveform data are available. We carry out several synthetic inversion tests to validate the method and assess the impact of parameterization including dispersion and variable rupture velocity in data predictions on the inversion results. Although each of these effects has been considered separately in previous studies, we show that it is important to consider them together in order to obtain more meaningful inversion results. Our results suggest that the discretization of the source, the use of dispersive waves, and accounting for source kinematics are all important factors in tsunami source inversion of large events such as the Tohoku‐Oki earthquake, particularly when an extensive set of high‐quality tsunami waveform recordings are available. For the Tohoku event, a dispersive model with variable rupture velocity results in a profound improvement in waveform fits that justify the higher source complexity and provide a more realistic source model.
Genome-wide association studies in pharmacogenomics: untapped potential for translation (2009)

Despite large public investments in genome-wide association studies of common human diseases, so far, few gene discoveries have led to applications for clinical medicine or public health. Genome-wide association studies in the context of clinical trials of drug safety and efficacy may be quicker to yield clinical applications. Certain methodological concerns, such as selection bias and confounding, may be mitigated when genome-wide association studies are conducted within clinical trials, in which randomization of exposure, prospective evaluation of outcome and careful definition of phenotype are incorporated by design.
The Environmental Sample Processor (ESP) ¿ An Autonomous Robotic Device for Detecting Microorganisms Remotely using Molecular Probe Technology (2006)

We are developing an instrument to conduct molecular biological analyses below the ocean surface, autonomously. The device is known as the Environmental Sample Processor, or ESP. The system is based on a modular design consisting of a core sample processor (the ESP), analytical modules and sampling modules. The core ESP provides the primary interface between the environment and a set of DNA and antibody-based tests that are carried out onboard the instrument in real-time. In addition, the ESP can be used to archive samples for a variety of analyses after the instrument is returned to a laboratory. Sampling modules are devices external to the core ESP that can be added to meet specialized needs, such as operating in the deep-sea (etc). Analytical modules are conceived of as stand-alone devices that can be added to the core ESP to impart different suites of analytical functions downstream of common sample processing operations. At the time of this writing we have worked most extensively on the core ESP and detection chemistries that involve DNA probe and protein arrays. The ESP has been deployed successfully in coastal ocean surface waters. We are also developing a sample collection module and pressure housing suitable for deploying the ESP at depths to 1000m. This version of the instrument is known as the deep-sea ESP, or D-ESP. The long-term objective of the D-ESP program is to provide a molecular analytical capability at deep-sea hot vents and cold seeps. The D-ESP will be deployed using an ROV and later transitioned to benthic moorings and a cabled observatory. Finally, we are just starting work to incorporate a microfluidic analytical module to support assays that require DNA purification and amplification
Performance Comparison of Two Controllers on a Nonlinear System (2013)

Various systems and instrumentation use auto tuning techniques in their operations. For example, audio processors, designed to control pitch in vocal and instrumental operations. The main aim of auto tuning is to conceal off-key errors, and allowing artists to perform genuinely despite slight deviation off-key. In this paper two Auto tuning control strategies are proposed. These are Proportional, Integral and Derivative (PID) control and Model Predictive Control (MPC). The PID and MPC controller's algorithms amalgamate the auto tuning method. These control strategies ascertains stability, effective and efficient performance on a nonlinear system. The paper test and compare the efficacy of each control strategy. This paper generously provides systematic tuning techniques for the PID controller than the MPC controller. Therefore in essence the PID has to give effective and efficient performance compared to the MPC. The PID depends mainly on three terms, the P ( ) gain, I ( ) gain and lastly D ( ) gain for control each playing unique role while the MPC has more information used to predict and control a system.