gebhart/patrepeval huggingface dataset:
Privacy preserving regression modelling via distributed computation (2004)

Reluctance of data owners to share their possibly confidential or proprietary data with others who own related databases is a serious impediment to conducting a mutually beneficial data mining analysis. We address the case of vertically partitioned data -- multiple data owners/agencies each possess a few attributes of every data record. We focus on the case of the agencies wanting to conduct a linear regression analysis with complete records without disclosing values of their own attributes. This paper describes an algorithm that enables such agencies to compute the exact regression coefficients of the global regression equation and also perform some basic goodness-of-fit diagnostics while protecting the confidentiality of their data. In more general settings beyond the privacy scenario, this algorithm can also be viewed as method for the distributed computation for regression analyses.
Ribosomal Proteins in Cell Proliferation and Apoptosis (1999)

Ribosomal proteins have the complex task of coordinating protein biosynthesis to maintain cell homeostasis and survival. Recent evidence suggests that a number of ribosomal proteins have secondary functions independent of their involvement in protein biosynthesis. A number of these proteins function as cell proliferation regulators and in some instances as inducers of cell death. Specifically, expression of human ribosomal protein L13a has been shown to induce apoptosis, presumably by arresting cell growth in the G2/M phase of the cell cycle. In addition, inhibition of expression of L13a induces apoptosis in target cells, suggesting that this protein is necessary for cell survival. Similar results have been obtained in the yeast Saccharomyces cerevisiae, where inactivation of the yeast homologues of L13a, rp22 and rp23, by homologous recombination results in severe growth retardation and death. In addition, a closely related ribosomal protein, L7, arrests cells in G1 and also induces apoptosis. Thus, it appears that a group of ribosomal proteins may function as cell cycle checkpoints and compose a new family of cell proliferation regulators.
Structural RIM IMR (1990)

Improvements in fuel economy and lower vehicle assembly costs have contributed to the variety of new materials used for composite parts fabrication. Distinguished among these are materials known as Structural RIM (SRIM). The focus of this paper is on the development of internal mold release technology specifically in relation to the preparation of SRIM composite parts. For the covering abstract of the proceedings see IRRD 860832.
Self-aligned setup for laser optical feedback imaging insensitive to parasitic optical feedback (2008)

We propose a new optical architecture for the laser optical feedback imaging (LOFI) technique which makes it possible to avoid the adverse effect of the optical parasitic backscattering introduced by all the optical interfaces located between the laser source and the studied object. This proposed setup needs no specific or complex alignment, which is why we can consider the proposed setup to be self-aligned. We describe the principle used to avoid the parasitic backscattering contributions that dramatically deteriorate amplitude and phase information contained in the LOFI images. Finally, we give a successful demonstration of amplitude and phase images obtained with this self-aligned setup in the presence of a parasitic reflection.
An Omega-3 Epoxide of Docosahexaenoic Acid Lowers Blood Pressure in Angiotensin-II–Dependent Hypertension (2014)

Mediators of antihypertensive actions of docosahexaenoic acid (DHA) are largely unknown. The omega-3 epoxide of DHA, 19, 20-EDP (epoxy docosapentaenoic acid), is metabolized by soluble epoxide hydrolase (sEH), which also metabolizes the anti-inflammatory and antihypertensive arachidonic acid epoxides, epoxyeicosatrienoic acids (EETs). Based in part on plasma levels of EDPs after a DHA-rich diet, we hypothesized that 19, 20-EDP contributes to the antihypertensive actions of DHA in angiotensin-II (Ang-II)-dependent hypertension. Treatment individually with 19, 20-EDP and a potent sEH inhibitor TPPU (1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea) significantly lowered blood pressure (BP) as compared with Ang-II-infused animals. The largest reduction in BP was obtained with the combination of 19, 20-EDP and TPPU, which was more efficacious than the combination of 14, 15-EET and TPPU. Oxylipin profiling revealed that 19, 20-EDP and 14, 15-EET infusion affected not only most metabolites of the P450 pathway but also renal levels of prostaglandin-E2. Our findings suggest that 19, 20-EDP is a mediator of the antihypertensive effects of DHA in Ang-II-dependent hypertension. It seems that 19, 20-EDP requires metabolic stabilization with a sEH inhibitor to be most effective in lowering BP, although both TPPU and 19, 20-EDP are so effective on their own that demonstrating additive or synergistic interactions is difficult.
Simvastatin Induces Regression of Cardiac Hypertrophy and Fibrosis and Improves Cardiac Function in a Transgenic Rabbit Model of Human Hypertrophic Cardiomyopathy (2001)

Simvastatin induced the regression of hypertrophy and fibrosis, improved cardiac function, and reduced ERK1/2 activity in the beta-myosin heavy chain-Q(403) rabbits. These findings highlight the need for clinical trials to determine the effects of simvastatin on cardiac hypertrophy, fibrosis, and dysfunction in humans with hypertrophic cardiomyopathy and heart failure.
Differential transcription factor occupancy but evolutionarily conserved chromatin features at the human and mouse M-CSF (CSF-1) receptor loci (2003)

The c-FMS gene encodes the macrophage colony-stimulating factor receptor (M-CSFR or CSF1-R), which is a tyrosine kinase growth factor receptor essential for macrophage development. We have previously characterized the chromatin features of the mouse gene; however, very little is known about chromatin structure and function of the human c-FMS locus. Here we present a side-by-side comparison of the chromatin structure, histone modification, transcription factor occupancy and cofactor recruitment of the human and the mouse c-FMS loci. We show that, similar to the mouse gene, the human c-FMS gene possesses a promoter and an intronic enhancer element (c-fms intronic regulatory element or FIRE). Both elements are evolutionarily conserved and specifically active in macrophages. However, we demonstrate by in vivo footprinting that both murine and human c-FMS cis-regulatory elements are recognised by an overlapping, but non-identical, set of transcription factors. Despite these differences, chromatin immunoprecipitation experiments show highly similar patterns of histone H3 modification and a similar distribution of chromatin modifying and remodelling activities at individual cis-regulatory elements and across the c-FMS locus. Our experiments support the hypothesis that the same regulatory principles operate at both genes via conserved cores of transcription factor binding sites.
Olefin polymerizations and polyolefin molecular weight distribution (1963)

Abstract A method for rapid determination of the nonuniformity coefficient, M w / M n , of linear polyethylenes and crystalline polypropylenes is described. The number‐average molecular weight M n was determined by counting the number of C 14 ‐labeled alkyl groups introduced into the polymers during the initiation step. The weight‐average molecular weight M w was calculated from viscometric data. The errors in these calculations were estimated. The values of M w / M n thus obtained for eleven samples of linear polyethylenes and three samples of crystalline polypropylenes are compared with the corresponding results obtained by polymer fractionations. The agreement was good for all the polyethylene and polypropylene samples studied except for three high viscosity polyethylene samples with high M w values and low M n values from fractionation data. The M w / M n values were determined for polymer samples taken during ethylene polymerizations initiated by the (C 5 H 5 ) 2 TiCl 2 –(CH 3 ) 2 AlCl system. This ratio at first decreased with the polymerization time, then reached a minimum as the concentration of growing chains reached a maximum. Comparison of polyethylene produced at various temperatures reveals that the width of polymer distribution decreases with rising polymerization temperatures. This decrease is attributed to the increase in the rates of initiation and termination and the higher activation energy for the termination processes. High catalyst concentrations yielded polyethylenes of broad distributions. At high catalyst concentrations, the concentrations of growing chains are also high. Consequently, more low molecular weight chains terminate early to give products with large M w / M n . On the other hand, increase of the Al/Ti ratio increases chain transfers giving polyethylenes having a low M w / M n . An additional effect of increasing the Al/Ti ratio is the decreased variation of M w / M n with t . The M w / M n values of crystalline polypropylene samples taken during polymerizations initiated by α‐TiCl 3 ‐(C 2 H 5 ) 2 AlCl are also presented. They were high at the beginning of the polymerizations and decreased gradually to a lower constant value. At higher temperatures, this variation was less pronounced; and the M w / M n values were lower than those for the polymers obtained at lower temperatures. The M w / M n values were insensitive to experimental variables such as the catalyst concentrations, the Al/Ti ratios, and the monomer pressures in agreement with the kinetic results. The M w / M n values of amorphous polypropylene samples taken during propylene polymerizations did not vary with t or with the other polymerization conditions. These results support the earlier kinetic interpretation that extensive chain transfers occur during the formation of amorphous polypropylenes.
A high-performance and memory-efficient architecture for H.264/AVC motion estimation (2008)

Variable-block-size motion estimation (VBSME) is a major contributor to H.264/AVC’s excellent coding efficiency. However, its high computational complexity and memory requirement make deign difficult. In this paper, we propose a memory-efficient hardware architecture for full-search VBSME (FSVBSME). Our architecture consists of sixteen 2-D arrays each consists of 16×16 processing elements (PEs). Four arrays form a group to match in parallel four reference blocks against one current block. Four groups perform block matching for four current blocks in a consecutive and overlapped fashion. Taking advantage of reference pixel overlapping between multiple reference blocks of a current block and between search windows of several adjacent current blocks, we propose a novel data reuse scheme to reduce memory access. Compared with the popular Level C data reuse method, our design can save 98% of on-chip memory access with only 27% of memory overhead. Synthesized into a TSMC 130nm CMOS cell library, our design takes 453K logic gates and 2.94K bytes of on-chip memory. Running at 130MHz, it is capable of processing 1920×1088 30fps video with 64×64 search range (SR) and two reference frames (RF). We suggest a criterion called design efficiency for comparing different related work. It shows that our design is 27% more efficient than the best design to date.
Validation of a novel method for measuring intra-abdominal pressure and gastric residual volume in critically ill patients (2014)

The results of this multicentre pilot study show that GRV can be measured with the new device. Furthermore this allows simultaneous screening for intra-abdominal hypertension with IAP estimation via IGP.
CDK2-Dependent Phosphorylation of FOXO1 as an Apoptotic Response to DNA Damage (2006)

The function of cyclin-dependent kinase 2 (CDK2) is often abolished after DNA damage. The inhibition of CDK2 plays a central role in DNA damage-induced cell cycle arrest and DNA repair. However, whether CDK2 also influences the survival of cells under genotoxic stress is unknown. Forkhead box O (FOXO) transcription factors are emerging as key regulators of cell survival. CDK2 specifically phosphorylated FOXO1 at serine-249 (Ser249) in vitro and in vivo. Phosphorylation of Ser249 resulted in cytoplasmic localization and inhibition of FOXO1. This phosphorylation was abrogated upon DNA damage through the cell cycle checkpoint pathway that is dependent on the protein kinases Chk1 and Chk2. Moreover, silencing of FOXO1 by small interfering RNA diminished DNA damage-induced death in both p53-deficient and p53-proficient cells. This effect was reversed by restored expression of FOXO1 in a manner depending on phosphorylation of Ser249. Functional interaction between CDK2 and FOXO1 provides a mechanism that regulates apoptotic cell death after DNA strand breakage.
Lactams. XXVI. Regioselectivity in the mercuric acetate-edetic acid oxidation of the ethyl 1-(2-aryl-2-hydroxyethyl)-3-ethyl-4-piperidineacetate system: Enhancement by a benzyloxy group in the aryl moiety and by the 3,4-cis configuration. (1986)

A quantitative analytical study to determine the isomer ratios of the 6-piperidones (type 7) and 2-piperidones (type 5) produced by the mercuric acetate-edetic acid (EDTA) oxidation of 1-(2-aryl-2-hydroxyethyl)-3-alkylpiperidines (±)-4c, d, f, h, 4e, g, i, j, and (±)-38 was carried out. It has been found that all the substrates with a benzyloxy group in the aryl moiety, regardless of its location, undergo oxidation at the 6-position preferentially as compared with the debenzyloxy derivatives such as (±)-4a, b. Comparison of the quantitative data from 4e and (±)-4f with those from (±)-4b indicated that the cis acetate chain at the 4-position increases the extent of the 6-oxidation, whereas a trans acetate chain at the same position has little effect. These two factors enhance the practical value of the "cincholoipon-incorporating method" for chiral syntheses of the 1-type Alangium alkaloids, in which the mercuric acetate-EDTA oxidation of 4e, g, i, j to the 6-piperidones (type 3)is one of the key synthetic operations.
Microstructural formation and effects on the performance of platinum modified aluminide coatings (1985)

The use of noble metal modified aluminide coatings has gained renewed interest as the requirements of improved protectivity for gas turbine engine components has increased. Increasing temperature, severity of operating environment and required lifetime extension are cited as reasons for their selection. While the literature documents examples of significant improvements in hot corrosion resistance at low (800 C) and high (800 C) temperatures and in cyclic oxidation with Pt additions, there are also examples of limited improvements and even detrimental effects. These controversies have been preliminarily ascribed to the considerable differences in microstructural features possible in these systems and to the variation in test procedures between laboratories, and between rigs and engines. A systematic study was therefore initiated to identify the microstructural variations obtained for platinum-modified aluminide coatings on IN738 and to develop a fundamental understanding of their mechanism of formation. In this final report, the several classical structural types are defined together with the beginnings of their formation understanding. These microstructures were then subjects to a series of tests under conditions including hot corrosion at 700 and 900 C, and cyclic oxidation. In addition, measurements of mechanical properties such as DBTT were performed. It was found tha platinum addition to a standard aluminate is beneficial at 900 C, so far as hot corrosion attack is concerned
LSI family for MUSE decoder (1990)

Twenty-five LSIs for the MUSE (multiple sub-Nyquist sampling encoding) decoder have been developed. The logic and memory LSIs were fabricated using CMOS technology. Both board area and power consumption of the MUSE decoder using these LSIs were reduced to 1/30 of that of prototype decoders using conventional ICs.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Behavioral effects of ivermectin in mice. (1999)

A cautious approach to initiating ivermectin treatment in mice should be used for sensitive behavioral experiments.
Leaf Senescence of Postproduction Poinsettias in Low-light Stress (1994)

Photosynthetic light harvesting was investigated under low-light stress conditions relevant to the problem of interior longevity of potted ornamental plants. Comparisons of leaf pigment levels and chlorophyll fluorescence excitation spectra were made for `Gutbier V-10 Amy' poinsettia ( Euphorbia pulcherrima Willd.), which has poor interior longevity, and `Eckespoint Lilo' poinsettia, which has superior interior longevity. The results show that `Eckespoint Lilo' had higher total chlorophyll content per leaf area and lower chlorophyll a: chlorophyll b ratio than `Gutbier V-10 Amy'. In low-light stress, `Eckespoint Lilo' retained its chlorophyll or even accumulated higher levels than in high light, while `Gutbier V-10 Amy' did not exhibit higher chlorophyll retention in low light. Both cultivars acclimatized to low-light stress by decreasing the chlorophyll a: chlorophyll b ratio, and this acclimatization was evident sooner in younger, outer-canopy leaves above the pinch than in older leaves below the pinch. Both cultivars also increased the chlorophyll: carotenoid ratio in low light. These changes in pigment composition, which were essentially structural changes, were reflected in functional changes in light harvesting, as assessed by measurements of chlorophyll fluorescence excitation spectra.
Cellular interpretation of multiple TGF-β signals: intracellular antagonism between activin/BVg1 and BMP-2/4 signaling mediated by Smads (1997)

During early embryogenesis of Xenopus, dorsoventral polarity of the mesoderm is established by dorsalizing and ventralizing agents, which are presumably mediated by the activity of an activin/BVg1-like protein and Bone Morphogenetic Proteins (BMP), respectively. Interestingly, these two TGF-beta subfamilies are found in overlapping regions during mesoderm patterning. This raises the question of how the presumptive mesodermal cells recognize the multiple TGF-beta signals and differentially interpret this information to assign a particular cell fate. In this study, we have exploited the well characterized model of Xenopus mesoderm induction to determine the intracellular interactions between BMP-2/4 and activin/BVg1 signaling cascades. Using a constitutively active BMP-2/4 receptor that transduces BMP-2/4 signals in a ligand-independent fashion, we demonstrate that signals provided by activin/BVg1 and BMP modulate each other's activity and that this crosstalk occurs through intracellular mechanisms. In assays using BMP-2/4 and activin/BVg1-specific reporters, we determined that the specificity of BMP-2/4 and activin/BVg1 signaling is mediated by Smad1 and Smad2, respectively. These Smads should be considered as the mediators of the intracellular antagonism between BMP-2/4 and activin/BVg1 signaling possibly through sequestration of a limited pool of Smad4. Consistent with such a mechanism, Smad4 interacts functionally with both Smad1 and -2 to potentiate their signaling activities, and a dominant negative variant of Smad4 can inhibit both activin/BVg1 and BMP-2/4 mediated signaling Finally, we demonstrate that an activin/BVg1-dependent transcriptional complex contains both Smad2 and Smad4 and thereby provides a physical basis for the functional involvement of both Smads in TGF-beta-dependent transcriptional regulation. Thus, Smad4 plays a central role in synergistically activating activin/BVg1 and BMP-dependent transcription and functions as an intracellular sensor for TGF-beta-related signals.
Heartbeat: Cardiac resynchronization therapy with or without defibrillation: are women different? (2017)

Cardiac resynchronization therapy (CRT) reduces symptoms and improves survival in heart failure patients with a low left ventricular ejection fraction and wide QRS complex. CRT devices can be configured to provide only pacing (CRT-P) or to include a defibrillator (CRT-D) with the goal of reducing the risk of sudden cardiac death (SCD). However, it is not clear which clinical parameters best distinguish those patients who will benefit from CRT-D versus those who should receive CRT-P. In this issue of Heart , Barra and colleagues1 report an observational study of 5307 consecutive patients undergoing CRT implantation for ischaemic or non-ischaemic dilated cardiomyopathy with no history of prior sustained ventricular arrhythmias. Propensity score matching was used to compare outcomes of those with CRT-D versus CRT-P with the aim of assessing whether outcomes differ by sex. In their analysis, the benefit of CRT-D was seen only in men (not women) with a HR for CRT-D compared with CRT-D of 0.78 (95% CI 0.65 to 0.94, p=0.012). (figure 1) The excess unadjusted SCD mortality in men with CRT-P was 7.4% compared with 2.2% in women.



Figure 1 
Survival curves comparing cardiac resynchronisation therapy defibrillator (CRT-D) versus cardiac resynchronisation therapy pacemaker (CRT-P) in female patients. 



In the accompanying editorial,2 Kutyifa notes that women accounted for only 15% of the CRT-D group but 42% of the CRT-P group, suggesting that sex may …
Plasma-binding Globulins and Acute Stress Response (2006)

Within studies of acute stress physiology an increase in glucocorticoid secretion is thought to be the primary mediator of tissue response to stress. Corticosteroid-binding globulin may regulate tissue availability of steroids, but has not been considered a dynamic component of the acute stress response. Here, we examined CBG level over the common 60-minute time frame in an acute capture and handling protocol to investigate whether CBG capacity is dynamic or static over short stressors. Using a comparative approach, we measured CBG response to capture and handling stress in nine species of birds, representing five orders and nine families. CBG capacity significantly declined within 30 - 60 minutes of capture in five of the nine species examined. This decline may serve to significantly increase the level of corticosterone reaching tissues during acute stress.
Simultaneous Spectral and Spatial Modulation for Color Printing and Holography Using All-Dielectric Metasurfaces (2019)

Metasurfaces possess the outstanding ability to tailor phase, amplitude, and even spectral responses of light with an unprecedented ultrahigh resolution and thus have attracted significant interest. Here, we propose and experimentally demonstrate a novel meta-device that integrates color printing and computer-generated holograms within a single-layer dielectric metasurface by modulating spectral and spatial responses at subwavelength scale, simultaneously. In our design, such metasurface appears as a microscopic color image under white light illumination, while encrypting two different holographic images that can be projected at the far-field when illuminated with red and green laser beams. We choose amorphous silicon dimers and nanofins as building components and use a modified parallel Gerchberg-Saxton algorithm to obtain multiple subholograms with arbitrary spatial shapes for image-indexed arrangements while avoiding the loss of phase information. Such a method can further extend the design freedom of metasurfaces. By exploiting spectral and spatial control at the level of individual pixels, multiple sets of independent information can be introduced into a single-layer device; the additional complexity and enlarged information capacity are promising for novel applications such as information security and anticounterfeiting.
New insights into the pathogenesis of pancreatitis (2013)

Recent advances challenge the long-believed trypsin-centered understanding of pancreatitis. It is becoming increasingly clear that activation of intense inflammatory signaling mechanisms in acinar cells is crucial to the pathogenesis of pancreatitis, which may explain the strong systemic inflammatory response in pancreatitis.