gebhart/patrepeval huggingface dataset:
Study of ion-molecule reaction mechanisms in acetonitrile by ion cyclotron resonance (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudy of ion-molecule reaction mechanisms in acetonitrile by ion cyclotron resonanceGeorge A. GrayCite this: J. Am. Chem. Soc. 1968, 90, 8, 2177–2179Publication Date (Print):April 1, 1968Publication History Published online1 May 2002Published inissue 1 April 1968https://pubs.acs.org/doi/10.1021/ja01010a044https://doi.org/10.1021/ja01010a044research-articleACS PublicationsRequest reuse permissionsArticle Views32Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Alternative RNA splicing (2015)

AccessScience is an authoritative and dynamic online resource that contains incisively written, high-quality educational material covering all major scientific disciplines. An acclaimed gateway to scientific knowledge, AccessScience is continually expanding the ways it can demonstrate and explain core, trustworthy scientific information that inspires and guides users to deeper knowledge.
Smart cards (1994)

From the Publisher:
Here's a thorough overview of the evolution of smart cards and the wide range of their emerging applications in finance, health care, universities, security, biometrics, and mobile communications. You'll find a detailed discussion of the state of the art, design, and programming. The authors show you how to choose a card by guiding you through each step involved in implementation and practical use.
Desktop English (1996)

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Identification of the Thief Zone Using a Support Vector Machine Method (2019)

Waterflooding is less effective at expanding reservoir production due to interwell thief zones. The thief zones may form during high water cut periods in the case of interconnected injectors and producers or lead to a total loss of injector fluid. We propose to identify the thief zone by using a support vector machine method. Considering the geological factors and development factors of the formation of the thief zone, the signal-to-noise ratio and correlation analysis method were used to select the relevant evaluation indices of the thief zone. The selected evaluation indices of the thief zone were taken as the input of the support vector machine model, and the corresponding recognition results of the thief zone were taken as the output of the support vector machine model. Through the training and learning of sample sets, the response relationship between thief zone and evaluation indices was determined. This method was used to identify 82 well groups in M oilfield, and the identification results were verified by a tracer monitoring method. The total identification accuracy was 89.02%, the positive sample identification accuracy was 92%, and the negative sample identification accuracy was 84.375%. The identification method easily obtains data, is easy to operate, has high identification accuracy, and can provide certain reference value for the formulation of profile control and water shutoff schemes in high water cut periods of oil reservoirs.
To what extent are arithmetic progressions of fractional parts stochastic? (2008)

For the sequence of residues of division of members of an arithmetic progression by a real number , it is proved that the Kolmogorov stochasticity parameter tends to 0 as tends to infinity when the progression step is commensurable with . In contrast, for the case when the step is incommensurable with , examples are given in which the stochasticity parameter not only does not tend to 0, but even takes some arbitrary large values (infrequently). Too small and too large values of the stochasticity parameter both indicate a small probability that the corresponding sequence is random. Thus, long arithmetic progressions of fractional parts are apparently much less stochastic than for geometric progressions (which provide moderate values of the stochasticity parameter, similar to its values for genuinely random sequences).
Markers of Asphyxia and Neonatal Brain Injury (1999)

Neonatal brain injury due to intrapartum asphyxia is an important cause of cerebral palsy, mental retardation, and epilepsy.1 Despite advances in perinatal care over the past three decades, the incidence of cerebral palsy attributed to birth asphyxia has not changed. One reason is that we do not know specifically how to intervene postnatally to prevent hypoxic–ischemic encephalopathy, which may follow intrapartum asphyxia and ultimately results in cerebral palsy.2 Nor do we know how to identify the neonates with asphyxia who are at greatest risk for encephalopathy and therefore are most likely to benefit from an intervention.Perinatal hypoxic–ischemic cerebral injury . . .
The McbR repressor modulated by the effector substance<i>S</i>‐adenosylhomocysteine controls directly the transcription of a regulon involved in sulphur metabolism of<i>Corynebacterium glutamicum</i>ATCC 13032 (2005)

In a recent proteomics study we have shown that the mcbR gene of Corynebacterium glutamicum ATCC 13032 most probably encodes a transcriptional repressor of the TetR type, which regulates the expression of at least six genes involved in the synthesis of sulphur-containing amino acids. By means of DNA microarray hybridizations we detected 86 genes with enhanced transcription in an mcbR mutant when compared with the wild-type strain. Bioinformatic analysis identified the inverted repeat 5'-TAGAC-N6-GTCTA-3' as a consensus sequence within the upstream region of 22 genes and operons, suggesting that the transcription of at least 45 genes is directly controlled by the McbR repressor. These 45 genes encode a variety of functions in (S-adenosyl)methionine and cysteine biosynthesis, in sulphate reduction, in uptake and utilization of sulphur-containing compounds and in transcriptional regulation. The function of the inverted repeat motif as potential McbR binding site in front of the genes hom, cysI, cysK, metK and mcbR was verified experimentally by competitive electrophoretic mobility shift analysis. A systematic search for the potential effector substance modulating the function of McbR revealed that only S-adenosylhomocysteine prevented the binding of McbR to its target sequence. These results indicate that the transcriptional repressor McbR directly regulates a set of genes comprising all aspects of transport and metabolism of the macroelement sulphur in C. glutamicum. As the activity of McbR is modulated by S-adenosylhomocysteine, a major product of transmethylation reactions, the results point also to a novel regulatory mechanism in bacteria to control the biosynthesis of S-adenosylmethionine.
Performance of Earthquake Isolation Systems (1990)

A comparison of the performances of three different base‐isolation systems, the laminated rubber bearing system, the New Zealand system, and the resilient‐friction base isolator system, is made under the same set of criteria. Conclusions pertaining to the ranges of the applicability of the systems for three earthquake sizes, M 6.0, 6.7, and 7.3, are obtained for a site located in the vicinity of the earthquake source (nominal source‐to‐site distance=10km). Two different seismological models of the earthquake source were used in modeling the spectral content of the earthquake input. The stochastic response of one‐story and five‐story base isolated structures is computed. The equivalent linearization technique is used to linearize the equations that govern those systems that are nonlinear. This study confirms the conclusions reached in previous studies by demonstrating again that friction plays an important role in energy absorption. This is the reason for the apparent superior performance of the resilient‐friction base isolator; system. However, more studies are needed to assess the feasibility of this system and to better understand its behavior by testing.
<title>Fabrication and evaluation of Cr-C multilayer mirrors for soft x rays</title> (1992)

We have selected Cr and C as a material pair of multilayer (ML) mirrors for soft x rays at the wavelength near 5 nm. The Cr-C ML structures have successfully been fabricated with rf- magnetron sputtering. The ML structures have been characterized with transmission electron microscopy (TEM), x-ray diffraction, and reflectivity measurement by SR light. From the observation of TEM images, Cr-C MLs had uniform and less-defective layered structures with the d-spacing down to 2.4 nm. Reflectivities at normal and grazing incidence were remarkably decreased with decreasing the ML d-spacing. Normal incidence reflectivity at 5 nm was as high as 7%. The regularity of the d-spacing of the MLs was evaluated with a moire image that was formed by putting a reference stripe pattern on the cross-sectional TEM micrograph. Compared to Ni-C MLs, Cr-C is a preferable material combination for x-ray mirrors for shorter wavelength and normal incidence.
A kinematic comparison between elderly and young subjects standing up from and sitting down in a chair (1998)

There is a relationship between changes in the motor control of the task, which appeared during periods of potential postural instability, and the effects of ageing on postural stability.
Abstract 272: Checkpoint inhibitor combinations in a human mixed leukocyte reaction (2015)

Abstract In an effort to identify effective target combinations, molecules specific for several immuno-oncology targets were combined in vitro using a mixed leukocyte reaction (MLR) assay. Briefly, 20 different healthy human peripheral blood mononuclear cell donor pairs were tested for proliferation and cytokine release in the presence of each molecule alone and in combination. The collection of agents targeted CTLA-4, PD-1, PD-L1, and CD73. Examples of significant (p&lt;0.05) synergy as well as antagonism and additivity were observed. In addition the phenotype and genotype of the MLR donor PBMCs were characterized. The results from this study are significant for at least two reasons: 1) In contrast to murine syngeneic models they represent aspects of multiple different human donor “immune responses” and 2) In contrast to purified T-cell assays they represent an assay system in which both the lymphoid and myeloid/innate immune compartments play a crucial role, and so better recapitulate a physiological T-cell response. Furthermore, these results provide information at the human population level, offering a glimpse of “responder” and “non-responder” population profiles. This information is impossible to obtain from the currently available collection of syngeneic mouse models. Citation Format: Erin Sult, Carl Hay, Qihui Huang, Stacy Fuhrmann, Robert Hollingsworth, Kris F. Sachsenmeier. Checkpoint inhibitor combinations in a human mixed leukocyte reaction. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 272. doi:10.1158/1538-7445.AM2015-272
Designer and Catalytic Antibodies (1990)

A HUMAN being possesses on the order of 1 trillion (1012) B cells, capable of making more than 10 million different antibodies. Tapping this vast resource for clinical purposes is an important but technically challenging endeavor. The production of hybridomas makes it feasible to manufacture large quantities of monoclonal antibodies, and in principle that method appeared to provide the ideal way to produce a large repertoire of human antibodies. Unfortunately, only mouse and rat myeloma cell lines have turned out to be reliable fusion partners for the production of stable hybridomas. Rodent monoclonal antibodies have provided many new reagents . . .
A Survey of Professor Reactions to Scenarios of Academic Dishonesty in American Universities (2007)

This study investigates the opinions of faculty members on the subject of academic integrity at two state universities in the western United States. Results show strong similarities for both universities. Most faculty members are lenient to first offenders and would counsel students after plagiarism is discovered. However, as a group they do little to promote student awareness on what constitutes academic dishonesty. Further, although most faculty members are more stringent in their reactions to second time offenders, most admit there is no tracking of such activities in their departments or schools. The faculties believe that student academic integrity is a problem at both schools.
Purification and Characterization of the Fibrinolytic Enzyme Produced by Bacillus subtilis KCK-7 from Chungkookjang (2004)

A fibrinolytic enzyme has been found in several bacteria isolated from fermented food. This study was carried out to investigate the purification and characteristics of the fibrinolytic enzyme produced by Bacillus subtilis KCK-7 originated from Chungkookjang. The fibrinolytic enzyme was purified to homogeneity from the culture supernatant using ammonium sulfate fractionation and chromatographies on DEAE-cellulose and on Sephadex G-100. The final specific activity of the purified enzyme increased 11.0-fold, and the protein amount in the purified enzyme was about 16% of that in the culture supernatant. The molecular weight of the purified enzyme was estimated to be about 45,000 by SDS-PAGE. The optimum pH and temperature for the enzyme activity were pH 7.0 and 60C, respectively. The enzyme activity was relatively stable up to 60C over the pH range of 7.0- 10.0. The fibrinolytic enzyme activity increased by Ca 2+ and Cu 2+ , whereas it was inhibited by Hg 2+ and Ba 2+ . In addition, it was severely inhibited by PMSF and DFT. It is suggested that the purified enzyme was a serine protease for the fibrinolysis. The purified enzyme could completely hydrolyze fibrin in vitro within 8 h. Hence, it is suggested that the purified enzyme can be put into practice as an effective thrombolytic agent.
A 3‐D Lagrangian finite element algorithm with remeshing for simulating large‐strain hydrodynamic instabilities in power law viscoelastic fluids (2014)

Abstract We present a three‐dimensional (3‐D) numerical algorithm (PINK‐3D) that is based on the finite element method. The algorithm is designed to simulate hydrodynamic instabilities in power law viscoelastic fluids under gravity. These instabilities are caused by large and sharp contrasts in mechanical strength and/or density between different materials (e.g., folding, necking, or Rayleigh‐Taylor diapirism). The instabilities are controlled by the geometry of the material interfaces and the related intralayer stress distribution when amplitudes of the material interfaces are still low. The presented algorithm combines a deformable Lagrangian mesh with remeshing in order to accurately simulate the low‐amplitude stages of the emerging instabilities, and also to simulate the large‐strain evolution of the structures emerging from these instabilities. The remeshing is based on material interfaces that accurately track the boundaries between materials with strongly varying material properties (e.g., effective viscosity or power law stress exponent). We describe here the main technical details of the 3‐D algorithm. The accuracy of the 3‐D algorithm is demonstrated with comparisons between the numerical results and 2‐D and 3‐D analytical solutions for folding, necking, Rayleigh‐Taylor diapirism, and circular inclusions in viscous medium. We also benchmark the 3‐D algorithm with results of a different 2‐D finite element algorithm to test the accuracy of the large‐strain results with remeshing. Furthermore, two tests are presented that show the accuracy of the viscoelasticity implementation. PINK‐3D is also used to study 3‐D necking applied to lithospheric slab detachment, and 2‐D and 3‐D folding applied to fold nappe formation. In particular, we apply the 3‐D code to quantify and visualize the evolution of the 3‐D finite strain ellipsoid for the developing 3‐D structures.
Effects of dietary daidzein and its metabolite, equol, at physiological concentrations on the growth of estrogen-dependent human breast cancer (MCF-7) tumors implanted in ovariectomized athymic mice (2006)

Genistein and daidzein are the main isoflavones in legumes. Equol is an intestinal bacterial metabolite of daidzein. In this study, we evaluated the estrogenic potential of daidzein and synthetic (+/-)-equol to stimulate growth of estrogen-dependent breast cancer (MCF-7) in vitro and in vivo. We hypothesize that estrogenic effects of daidzein and (+/-)-equol could modulate the growth of MCF-7 cells both in vitro and also once implanted into ovariectomized athymic mice. At concentrations between 0.001 and 50 microM, daidzein and (+/-)-equol stimulated the growth of MCF-7 cells with maximal stimulation at 1 muM in vitro. To evaluate their effects on the growth of MCF-7 cells implanted in ovariectomized athymic mice, two dietary dose-response studies [daidzein (125, 250, 500 and 1000 p.p.m.) and (+/-)-equol (250, 500 and 1000 p.p.m.)] were conducted. Tumor size and body weight were monitored weekly during the study. At completion of the study, we analyzed cellular proliferation of tumors using immunohistochemical staining (ki-67), pS2 expression in tumors using a real time quantitative reverse transcription-polymerase chain reaction (qRT-PCR), and total daidzein and (+/-)-equol levels in plasma using liquid chromatography-electrospray tandem mass spectrometry (LC-ES/MS/MS). Dietary daidzein had a slight but significant stimulatory effect on MCF-7 tumor growth in mice. No significant induction of pS2 mRNA (an estrogen-responsive marker) in tumors by dietary daidzein was observed. Total plasma daidzein concentrations in plasma were between 0.25 and 1.52 microM. Dietary equol treatment (for 37 weeks) did not stimulate MCF-7 tumor growth. There were no statistical differences in tumor size, proliferation and pS2 expression among any treatment groups. Total equol concentrations in plasma were 2.10-3.21 microM. In conclusion, daidzein and (+/-)-equol have proliferative effects on MCF-7 cell growth in vitro within the concentration range tested. Dietary daidzein had a slight but significant stimulatory effect on tumor growth, whereas (+/-)-equol did not stimulate the growth of estrogen-dependent breast tumor growth in athymic mice, increase the cell proliferation in tumors, or induce an estrogen-responsive pS2 expression. Total daidzein or (+/-)-equol plasma levels in mice fed the isoflavones were in the range that stimulated MCF-7 cell growth in vitro. These results suggest that pharmacokinetic and/or metabolic factors attenuate the estrogenic effects of daidzein and equol in vivo.
Serum concentrations of cortisol, interleukin 6, leptin and adiponectin predict stress induced insulin resistance in acute inflammatory reactions (2008)

Serum cortisol levels are the best predictor for inflammatory insulin resistance followed by IL6, leptin and adiponectin. TNFalpha, and resistin have minor relevance as predictors of stress dependent insulin resistance.
Glycoside hydrolase DisH from <i>Desulfovibrio vulgaris</i> degrades the <i>N‐</i> acetylgalactosamine component of diverse biofilms (2018)

Biofilms of sulfate-reducing bacteria (SRB) produce H<sub>2</sub> S, which contributes to corrosion. Although bacterial cells in biofilms are cemented together, they often dissolve their own biofilm to allow the cells to disperse. Using Desulfovibrio vulgaris as a model SRB, we sought polysaccharide-degrading enzymes that disperse its biofilm. Using a whole-genome approach, we identified eight enzymes as putative extracellular glycoside hydrolases including DisH (DVU2239, dispersal hexosaminidase), an enzyme that we demonstrated here, by utilizing various p-nitrooligosaccharide substrates, to be an N-acetyl-β-D-hexosaminidase. For N-acetyl-β-D-galactosamine (GalNAc), V<sub>max</sub> was 3.6 µmol of p-nitrophenyl/min (mg protein)<sup>-1</sup> and K<sub>m</sub> was 0.8 mM; the specific activity for N-acetyl β-D-glucosamine (GlcNAc) was 7.8 µmol of p-nitrophenyl/min (mg protein)<sup>-1</sup> . Since GalNAc is one of the three exopolysaccharide matrix components of D. vulgaris, purified DisH was found to disperse 63 ± 2% biofilm as well as inhibit biofilm formation up to 47 ± 4%. The temperature and pH optima are 60°C and pH 6, respectively; DisH is also inhibited by copper and is secreted. In addition, since polymers of GalNAc and GlcNAc are found in the matrix of diverse bacteria, DisH dispersed biofilms of Pseudomonas aeruginosa, Escherichia coli and Bacillus subtilis. Therefore, DisH has the potential to inhibit and disperse a wide-range of biofilms.
Hemagglutination Inhibition Antibody Titers as a Correlate of Protection for Inactivated Influenza Vaccines in Children (2011)

The use of the 1:40 HI adult correlate of protection is not appropriate when evaluating influenza vaccines in children. Although a cutoff of 1:110 may be used to predict the conventional 50% clinical protection rate, a titer of 1:330 would predict an 80% protective level, which would seem to be more desirable from a public health perspective.
Semi-Autonomous Controller for Data Acquisition the Brilliant ADC (1978)

A set of high speed 16-bit computers and ADC's has been designed and built for the data collection, compression, and correction system of the SLAC/LBL Mark II Magnetic Detector. The "Brilliant ADC" controls the analog multiplexing of a CAMAC crate of data acquisition modules, digitizes the analog data, and executes microprogrammed algorithms for data handling and correction.