gebhart/patrepeval huggingface dataset:
Semiblind estimation of spatio-temporal filter coefficients based on a training-like approach (1998)

A semiblind approach for equalization and jammers rejection at the base station in wireless communications is presented. It is based on the idea of enlarging the effective length of a known short training sequence by using a few additional information symbols and the finite alphabet property of the communication signals. Simulation results for spatio-temporal processing of 4-QPSK signals transmitted by simultaneous intracell users demonstrate the advantage of the proposed approach in situations where the length of the training sequence is not large enough to allow estimation of the desired signal with previously proposed methods.
<b>Nuclear Magnetic Resonance Spectra of Some Hypofluorites</b> (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNuclear Magnetic Resonance Spectra of Some HypofluoritesGeorge H. Cady and Claude I. MerrillCite this: J. Am. Chem. Soc. 1962, 84, 11, 2260–2262Publication Date (Print):June 1, 1962Publication History Published online1 May 2002Published inissue 1 June 1962https://pubs.acs.org/doi/10.1021/ja00870a051https://doi.org/10.1021/ja00870a051research-articleACS PublicationsRequest reuse permissionsArticle Views38Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Association between serotonin transporter gene polymorphisms and depressed mood caused by job stress in Japanese workers (2008)

To estimate the genetic factors influencing depressed mood caused by job stress, a total of 243 employees at a manufacturing company and a local hospital in Japan (mean age 40.8+/-10.3 years) were recruited with informed consent. The Brief Job Stress Questionnaire was used to assess the present status of stress. Alcohol consumption and smoking were assessed as lifestyle factors. DNA samples were prepared to detect gene polymorphisms of serotonin transporter (5HTT), aldehyde dehydrogenase 2, D2 dopamine receptor, and cytochrome p450 2A6. The relationship between job stress, lifestyle factors and these polymorphisms was assessed for each gender. The level of depressed mood for female subjects was significantly higher among the carriers of two short (s/s) alleles of the 5HTT regulatory region compared with the carriers of one (s/l) or two (l/l) long alleles (Mann-Whitney U test, p<0.05). The odds ratio of depressed mood also confirmed this relationship for the female subjects, whereas there was no relationship for the male subjects. When social support was taken into consideration, the depressed mood score for those who had high support was significantly lower than for those who had low support, irrespective of 5HTT polymorphisms and gender. Job stress may elicit biological responses that contribute to depressed mood in relation to 5HTT polymorphisms, and social support may reduce depressed mood irrespective of 5HTT polymorphisms.
Full-Space Electronic Beam-Steering Transmitarray With Integrated Leaky-Wave Feed (2016)

A new low-profile, full-space, electronic beam-steering antenna architecture which combines the full-space beam-steering properties of reconfigurable transmitarrays with the low-profile feeding characteristics of leaky-wave antennas is proposed. The design uses an integrated leaky-wave feed to spatially distribute power across a reconfigurable transmitarray aperture in a low-profile manner while individual element phase control using varactor diodes enables full-space pencil-beam-steering. A $6\times 6$ element array was fabricated and experimentally verified, and full-space (both azimuth and elevation) beam-steering was demonstrated at angles up to 45° off broadside with a total efficiency for all scan angles on the order of 25%-35%. The design demonstrates a tenfold reduction in the overall thickness over the original transmitarray, improved aperture amplitude distribution control, as well as improved spillover control. The design also acts as a lower cost, scalable alternative to phased arrays as it does not require a complicated beamforming network and the feed and aperture are easily scaled.
A New Approach to Supertough Poly(lactic acid): A High Temperature Reactive Blending (2016)

A novel approach to PLA toughening is proposed in this study. Poly(lactic acid) (PLA) is toughened using poly(ethylene‐ n ‐butylene‐acrylate‐ co ‐glycydyl methacrylate) (EBA‐GMA) as a reactive compatibilizer with the aid of an epoxy‐based chain extender. It is found that the toughening effect of EBA‐GMA in the binary blend investigated is strongly influenced by blending temperature. Blending at high temperatures which are non‐typical for PLA processing (over 250 °C) allows toughness to be increased by an order of magnitude when compared to the toughness of blends prepared at low temperatures (below 200 °C). This effect is attributed to a combination of factors, namely an increasing rate of reactive bonding between PLA and EBA‐GMA at elevated temperatures and enhanced interfacial adhesion between PLA and EBA‐GMA phases. DSC studies show that PLA/EBA‐GMA bonding on the interface acts as an efficient nucleator for PLA. The nucleation ability of the PLA/EBA‐GMA interface strongly depends on blend processing temperature and gradually increases with increasing blending temperature. The PLA/EBA‐GMA interface shows its highest nucleation ability at 250 °C. image
Experimental conformational study of two peptides containing α‐aminoisobutyric acid. Crystal structure of <i>N</i>‐acetyl‐α‐aminoisobutyric acid methylamide (1978)

Abstract Some theoretical studies have predicted that the conformational freedom of the α‐aminoisobutyric acid (H‐Aib‐OH) residue is restricted to the α‐helical region of the Ramachandran map. In order to obtain conformational experimental data, two model peptide derivatives, MeCO‐Aib‐NHMe 1 and Bu t CO‐LPro‐Aib‐NHMe 2 , have been investigated. The Aib dipeptide 1 crystallizes in the monoclinic system ( a = 12.71 Å, b = 10.19 Å, c = 7.29 Å, β = 110.02°, Cc space group) and its crystal structure was elucidated by x‐ray diffraction analysis. The azimuthal angles depicting the molecular conformation (ϕ = −55.5°, ψ = −39.3°) fall in the α‐helical region of the Ramachandran map and molecules are hydrogen‐bonded in a three‐dimensional network. In CCl 4 solution, ir spectroscopy provides evidence for the occurrence of the so‐called 5 and C 7 conformers stabilized by the intramolecular i → i and i + 2 → i hydrogen bonds, respectively. The tripeptide 2 was studied in various solvents [CCl 4 , CD 2 Cl 2 , CDCl 3 , (CD 3 ) 2 SO, and D 2 O] by ir and pmr spectroscopies. It was shown to accommodate predominantly the βII folded state stabilized by the i + 3 → i hydrogen bond. All these experimental findings indicate that the Aib residue displays the same conformational behavior as the other natural chiral amino acid residues.
Ribonuclease a Cleavage Combined with the Polymerase Chain Reaction for Detection of the Z Mutation of the α-1-Antitrypsin Gene (1989)

Homozygous inheritance of the Z mutation (exon V, Glu342GAG----Lys342AAG), the most common cause of alpha-1-antitrypsin (alpha 1AT) deficiency, is associated with a high risk for emphysema and liver disease. This study presents a rapid and accurate approach to definitive genotypic diagnosis of the Z homozygous state using a combination of polymerase chain reaction amplification of exon V of the alpha 1AT gene and ribonuclease cleavage of an exon V-specific antisense RNA probe. Taking advantage of the concept that ribonuclease A will cleave at points of mismatch of RNA-DNA hybrids, a 0.79 kb antisense RNA probe was designed with complementarity to the sense strand of exon V of the alpha 1AT gene (the site of the Z mutation) along with small regions of the 5' and 3' flanking sequences. After amplification of exon V of the alpha 1AT gene from genomic DNA by the polymerase chain reaction, the amplified DNA was analyzed by hybridization to a 32P-labeled exon V antisense RNA probe followed by digestion with RNase A. Any substitution mutations resulting in DNA-RNA mismatch were detected by evaluation with polyacrylamide gel electrophoresis under denaturing conditions followed by autoradiography (expected fragment lengths: 0.33 kb when the exon V probe hybridized to the normal amplified genomic DNA, 0.25 and 0.08 kb fragments when the exon V probe hybridized to the amplified genomic DNA with the Z mutation). Double-blinded evaluation of genomic DNA of 36 individuals (phenotypes MM n = 14, MZ n = 5, ZZ n = 16, ZNull n = 1; included among the "M" alleles were representatives of all the major normal M alleles) demonstrated definitive diagnosis of the Z mutation with absolute specificity for all 36 specimens, i.e., ZZ homozygotes, MZ heterozygotes, and normals were all detected accurately. This approach should be useful not only for screening for the Z mutation of the alpha 1AT gene, but by this type of analysis, mutational alterations of the alpha 1AT gene can be screened for without prior knowledge of the sequence changes and without complex cloning and sequencing methods.
Fibronectin Type III Repeats Mediate RGD-independent Adhesion and Signaling through Activated β1 Integrins (1997)

Many cell-surface and extracellular matrix proteins contain multiple modular domains known as fibronectin type III (FNIII) repeats. Cells adhere to the extracellular matrix proteins fibronectin and tenascin in part by the interaction of certain integrins with the Arg-Gly-Asp (RGD) sequence, displayed on specific FNIII repeats. We have found that, after experimental activation of beta1 integrins, a number of cell types adhere and spread on FNIII repeats lacking RGD, derived from extracellular matrix proteins and cytokine receptors. Interaction between individual FNIII domains and beta1 integrins mediates focal adhesion kinase phosphorylation and subsequent stress fiber and focal contact formation. These data suggest that many FNIII-containing proteins may bind and signal through activated beta1 integrins, dramatically expanding the potential for integrin-dependent intercellular and cell-matrix communication.
Monolithic FET structures for high-power control component applications (1989)

A monolithic FET switch is described that can be integrated with other monolithic functions or used as a discrete component in a microwave integrated circuit structure. This device increases the power-handling capability of the conventional single FET switch by an order of magnitude. It does this by overcoming the breakdown voltage limitation of the FET device. The design, fabrication and performance of two high-power control components using these circuits are described as examples of the implementation of this technology. They are an L-band terminated single-pole, single-throw (SPST) switch and an L-band limiter.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Description and Validation of a Flexible and Broadly Usable Handedness Questionnaire (1998)

Empirical evidence is provided which shows that handedness questionnaires should: (a) comprise items that cover skilled and unskilled activities; (b) be sufficiently long to capture a ''mass effect'' of variability in lateral preferences over a range of items; and (c) allow graded answer options for individual items rather than forced left/right choices. When using questionnaires that meet these criteria, it is possible to establish significant correlations between hand preference and performance even within a group of right-handers. In addition, such questionnaires are flexible enough to accommodate a great variety of handedness classification schemes.
Variations on the Histogram (2009)

When constructing a histogram, it is common to make all bars the same width. One could also choose to make them all have the same area. These two options have complementary strengths and weaknesses; the equal-width histogram oversmooths in regions of high density, and is poor at identifying sharp peaks; the equal-area histogram oversmooths in regions of low density, and so does not identify outliers. We describe a compromise approach which avoids both of these defects. We regard the histogram as an exploratory device, rather than as an estimate of a density. We argue that relying on the asymptotics of integrated mean squared error leads to inappropriate recommendations for choosing bin-widths. Datasets and R codes are available in the online supplements.
Do Firms' Product Lines Include Too Many Varieties? (1997)

A firm that offers an additional product can capture business from rival firms for other products when consumers prefer to concentrate their purchases at a single supplier. This may lead firms to offer excessive product variety from the social standpoint. A firm may even completely foreclose competing firms from the market by introducing a new product. Forbidding new product introductions (e.g., forbidding universal banking or forbidding a new airline route), forbidding mergers that broaden firms' product lines (as, e.g., the EC forbade a merger of commuter aircraft manufacturers), and forbidding Sunday shopping may sometimes be appropriate public policies.
TCRab Deficient CAR T-Cells Targeting CD123: An Allogeneic Approach of Adoptive Immunotherapy for the Treatment of Acute Myeloid Leukemia (AML) (2015)

Abstract The remissions achieved using autologous T-cells expressing chimeric antigen receptors (CARs) in patients with advanced B cell leukemia and lymphomas have encouraged the use of CAR technology to treat different types of cancers by targeting distinct tumor-specific antigens. Since the current autologous approach utilizes CAR T-cells manufactured on a "per patient" basis, we propose an alternative approach based on the use of a standardized platform for manufacturing T-cells from third-party healthy donors to generate allogeneic "off-the-shelf" CAR T-cell-based frozen products. In the present work we have adapted this allogeneic platform to the production of T-cells targeting CD123, the transmembrane alpha chain of the interleukin-3 receptor, which is expressed on tumor cells from the majority of patients with Acute Myeloid Leukemia (AML). Multiple antigen recognition domains were screened in the context of different CAR architectures to identify candidates displaying activity against cells expressing variable levels of the CD123 antigen. The three lead candidates were tested in an orthotopic human AML cell line xenograft mouse model. From the three candidates that displayed comparable activity in vitro, we found two candidates capable of eradicating tumor cells in vivo with high efficiency. Subsequently, Transcription Activator-Like Effector Nuclease (TALEN) gene editing technology was used to inactivate the TCRα constant (TRAC) gene, eliminating the potential for engineered T-cells to mediate Graft versus Host Disease (GvHD). Editing of the TRAC gene can be achieved at high frequencies, and allows efficient amplification of TCR-deficient T-cells that no longer mediate alloreactivity in a xeno-GvHD mouse model. In addition, we show that TCR-deficient T-cells display equivalent in vitro and in vivo activity to non-edited T-cells expressing the same CAR. We have performed an initial evaluation of the expression of CD123 in AML patients and found an average cell surface expression of CD123 was of 67% in leukemic blasts (95% CI 48-82), 71% in CD34+CD38+ cells (95% CI 56-86), and 64% in CD34+CD38- (95% CI 41-87). Importantly, we have found that CD123 surface expression persists in CD34+CD38-CD90- cells after therapy in at least 20% of patients in remission (n=25), thus emphasizing the relevance of the target. Currently, the sensitivity of primary AML cells to CAR T-cells is being tested. Finally, we will also present our large scale manufacturing process of allogeneic CD123 specific T-cells from healthy donors, showing the feasibility for this off-the-shelf T-cell product that could be available for administration to a large number of AML patients. Disclosures Galetto: Cellectis SA: Employment. Lebuhotel:Cellectis SA: Employment. Gouble:Cellectis SA: Employment. Smith:Cellectis: Employment, Patents & Royalties.
The Pathogenesis of Severe Fever with Thrombocytopenia Syndrome Virus Infection in Alpha/Beta Interferon Knockout Mice: Insights into the Pathologic Mechanisms of a New Viral Hemorrhagic Fever (2013)

Severe fever with thrombocytopenia syndrome virus (SFTSV) is a newly discovered Phlebovirus causing an emerging hemorrhagic fever in East Asia, with reported case fatality rates up to 30%. Despite the high case fatality rate and large number of persons at risk of infection, the pathobiology of the disease is unknown, and no effective animal model has been available for investigating its pathogenesis. We have studied mice and hamsters as potential small-animal models of SFTSV infection following subcutaneous, intraperitoneal, or intracerebral inoculation. Animal tissues were processed for viral load determination, histopathology, immunohistochemistry, and confocal microscopic studies. We found that immunocompetent adult mice and hamsters did not become ill after SFTSV infection. However, alpha/beta interferon receptor knockout (IFNAR(-/-)) mice were highly susceptible to SFTSV infection, and all mice died within 3 to 4 days after subcutaneous inoculation of 10(6) focus-forming units of SFTSV. Histologic examination of tissues of IFNAR(-/-) mice infected with SFTSV showed no detectable lesions. In contrast, by immunohistochemistry virus antigen was found in liver, intestine, kidney, spleen, lymphoid tissue, and brain, but not in the lungs. Mesenteric lymph nodes and spleen were the most heavily infected tissues. Quantitative reverse transcription-PCR (RT-PCR) confirmed the presence of virus in these tissues. Confocal microscopy showed that SFTSV colocalized with reticular cells but did not colocalize with dendritic cells, monocytes/macrophages, neutrophils, or endothelium. Our results indicate that SFTSV multiplied in all organs except for lungs and that mesenteric lymph nodes and spleen were the most heavily infected tissues. The major target cells of SFTSV appear to be reticular cells in lymphoid tissues of intestine and spleen.
Spatial object model[l]ing in fuzzy topological spaces : with applications to land cover change (2004)

The central topic of this thesis focuses on the accommodation of fuzzy spatial objects in a GIS. Several issues are discussed theoretically and practically, including the definition of fuzzy spatial objects, the topological relations between them, the modeling of fuzzy spatial objects, the generation of fuzzy spatial objects and the utilization of fuzzy spatial objects for land cover changes.
Update for nurse anesthetists. Patr 1. The hazards of surgical smoke. (2001)

Inhaling surgical smoke is an ever-growing concern since the majority of all surgeries generate laser or electrosurgical smoke. Anesthesia providers must understand the dangers of surgical smoke and how to control or minimize exposure. This Journal course explores the hazards of surgical smoke (including plume odor, particulate matter size, viability of the smoke contents, and laparoscopic concerns) by citing significant research studies that support the threats and potential threats associated with surgical smoke. Effective methods to evacuate this plume are described to protect not only the healthcare professional but also the patient. Surgical smoke will continue to cause problems and concerns unless the surgical team is committed to providing a safe environment through appropriate and diligent smoke evacuation methods.
Towards a therapy for mitochondrial disease: an update (2018)

Preclinical work aimed at developing new therapies for mitochondrial diseases has recently given new hopes and opened unexpected perspectives for the patients affected by these pathologies. In contrast, only minor progresses have been achieved so far in the translation into the clinics. Many challenges are still ahead, including the need for a better characterization of the pharmacological effects of the different approaches and the design of appropriate clinical trials with robust outcome measures for this extremely heterogeneous, rare, and complex group of disorders. In this review, we will discuss the most important achievements and the major challenges in this very dynamic research field.
A GENERATIVE APPROACH TO THE DEVELOPMENT OF HIDDEN‐FIGURE ITEMS (1986)

ABSTRACT This report explores an approach to item development and psychometric modeling which explicitly incorporates knowledge about the mental models used by examinees in the solution of items into a psychometric model that characterize performances on a test, as well as incorporating that knowledge into the item development process. The paper focuses on the hidden figure item type. Although there is an extensive literature on the correlates of performance for this type of item little is known about the mental models that may explain performance on the item. The approach taken in this paper is to search for a complexity dimension that accounts for the difficulty of hidden figures. Although several complexity dimensions can be postulated we chose one inspired by artificial intelligence research on vision. A computer‐based system was developed to analyze as well as generate items based on this framework. To empirically determine the validity of the chosen framework two experiments were conducted. The results suggest that this approach to psychometric modeling is viable. The practical and theoretical implications of the research are discussed.
New Fractional Results for a Boundary Value Problem with Caputo Derivative (2013)

In this paper, we consider three point boundary value problem for fractional dierential equations of order 1 < < 2. We establish new conditions for the existence and uniqueness of solutions by using Banach xed point theorem. We also generate other existence results using Scheafer and Krasnoselskii xed point theorems.
Cloning, expression and characterization of a novel four EF‐hand Ca<sup>2+</sup>‐binding protein from olive pollen with allergenic activity (2000)

A novel allergenic member of the family of Ca(2+)-binding proteins has been cloned from olive tree pollen. The isolated DNA codes for a protein of 171 amino acid residues, which displays four EF-hand sequence motifs. The encoded protein was overproduced in Escherichia coli and purified. The protein (18¿ omitted¿795 Da), which binds Ca(2+) and IgE antibodies from patients allergic to olive pollen, undergoes Ca(2+)-dependent conformational changes. It is retained on a phenyl-Sepharose column, which indicates the existence of regulatory EF-hand domains. This fact suggests its involvement in Ca(2+)-dependent signal transduction events of the pollen grain. This allergen could be considered as a member of a new subfamily of EF-hand Ca(2+)-binding proteins since it displays a low amino acid sequence similarity with the so far known proteins.