gebhart/patrepeval huggingface dataset:
Enhanced delivery of a monoclonal antibody F(ab')2 fragment to subcutaneous human glioma xenografts using local hyperthermia. (1990)

The purpose of this study was to investigate the effects of tumor-localized hyperthermia at 42 degrees C on the tissue distribution of radioiodinated monoclonal antibody F(ab')2 fragments. Paired-label biodistribution measurements were performed in athymic mice bearing D-54 MG human glioma xenografts on one leg. Mice received both the 131I-labeled F(ab')2 fragment of Mel-14, reactive with human gliomas and melanomas, and nonspecific 125I-labeled RPC 5 F(ab')2. Tumor-bearing legs were placed in a 42 degrees C water bath or a 37 degrees C water bath (control) for 2 or 4 h. In mice sacrificed immediately after 2 h of heating, no hyperthermia-induced differences in the distribution of either fragment were observed. In the 4-h groups, tumor uptake of Mel-14 F(ab')2 increased from 7.04 +/- 1.59% injected dose (ID)/g at 37 degrees C to 20.65 +/- 4.53% ID/g at 42 degrees C (P less than 0.0001), and tumor localization of the control fragment rose from 5.23 +/- 1.35% ID/g to 14.51 +/- 1.37% ID/g (P less than 0.0001). In another experiment, F(ab')2 fragments were injected, tumors were heated for 4 h, and groups were sacrificed at 4, 8, and 16 h after injection. Statistically significant 2- to 3-fold higher uptake of both fragments in tumor were observed at all time points. Hyperthermic conditions also resulted in higher tumor:tissue ratios for both fragments. These results suggest that it may be possible to use tumor-localized hyperthermia to increase the therapeutic utility of radiolabeled monoclonal antibodies, particularly when labeled with short lived nuclides such as the 7.2-h alpha-emitter 211At.
<title>Optically pre-amplified lidar-radar</title> (2001)

We present the concept of an optically pre-amplified intensity modulated lidar, where the modulation frequency is in the microwave domain (1-10 GHz). Such a system permits to combine directivity of laser beams with mature radar processing. As an intensity modulated or dual-frequency laser beam is directed on a target, the backscattered intensity is collected by an optical system, pass through an optical preamplifier, and is detected on a high speed photodiode in a direct detection scheme. A radar type processing permits then to extract range, speed and identification information. The association of spatially multimode amplifier and direct detection allows low sensitivity to atmospheric turbulence and large field of view. We demonstrated theoretically that optical pre-amplification can greatly enhance sensitivity, even in spatially multimode amplifiers, such as free-space amplifier or multimode doped fiber. Computed range estimates based on this concept are presented. Laboratory demonstrations using 1 to 3 GHz modulated laser sources and >20 dB gain in multimode amplifiers are detailed. Preliminary experimental results on range and speed measurements and possible use for large amplitude vibrometry will be presented.
Peparation of New Nitrogen-bridged Heterocycles. 21. A Facile Synthesis of 2-Indolizinethiols Using New Protecting Groups (1990)

Abstract Some indolizine derivatives having (2-cyanoethyl)thio or (2-ethoxycarbonylethyl)thio group at the 2-position were prepared in moderate to good yields starting from the corresponding pyridinium 1-(thiocarbonyl)methylides. The treatment of these indolizines with a strong base such as potassium t-butoxide in N,N-dimethylformamide (DMF) gave smoothly title compounds, 2-indolizinethiols, with the elimination of acrylonitrile or ethyl acrylate.
Computing an Initial Estimate of a Wiener–Hammerstein System With a Random Phase Multisine Excitation (2005)

Wiener-Hammerstein systems consist of two linear dynamic systems placed around a static nonlinearity. These models are difficult to identify due to the presence of two dynamic systems. Usually, a nonlinear estimation procedure is necessary to estimate the parameters of the different parts. This nonlinear estimation procedure needs good starting values to converge quickly and/or reliably to a global minimum. This paper proposes a method to compute a first estimate based on one measurement record only.
Synthesis and Opioid Activity of [Sar<sup><b>4</b></sup>]Dermorphin-Tetrapeptide Analogues (1984)

The modification of the dermorphin-(1-4)-tetrapeptide structure led to analogues with potent opioid activity in vitro and in vivo. [Sar4]Tetrapeptides such as H2N-CH(NH)-Tyr-D-Ala-Phe-Sar-D-NH-CH(CH3)C6H5 (VII) whose terminal amino group is replaced by the guanidino function and whose C-terminus is amidated by (R)-(+)-alpha-methylbenzylamine, show peripheral and central opioid activities comparable to or higher than those of dermorphin. The potency of VII in the different tests was as follows: guinea-pig ileum (GPI) IC50 = 0.09nM, mouse Vas deferens (MVD) IC50 = 0.69nM, tail-flick ED50 = 8.91 pmol/mouse, i.c.v. and 4.54 mumol/kg, s.c. This dermorphin-(1-4)-tetrapeptide derivative is about 650 and 950 times as active as morphine in the two in vitro tests, respectively. The MVD/GPI potency ratio of the new peptides suggests a mu-type agonist behaviour.
Thermally Reversible Aggregation of Gold Nanoparticles in Polymer Nanocomposites through Hydrogen Bonding (2013)

The ability to tune the state of dispersion or aggregation of nanoparticles within polymer-based nanocomposites, through variations in the chemical and physical interactions with the polymer matrix, is desirable for the design of materials with switchable properties. In this study, we introduce a simple and effective means of reversibly controlling the association state of nanoparticles based on the thermal sensitivity of hydrogen bonds between the nanoparticle ligands and the matrix. Strong hydrogen bonding interactions provide excellent dispersion of gold nanoparticles functionalized with poly(styrene-r-2-vinylpyridine) [P(S-r-2VP)] ligands in a poly(styrene-r-4-vinyl phenol) [P(S-r-4VPh)] matrix. However, annealing at higher temperatures diminishes the strength of these hydrogen bonds, driving the nanoparticles to aggregate. This behavior is largely reversible upon annealing at reduced temperature with redispersion occurring on a time-scale of ~30 min for samples annealed 50 °C above the glass transition temperature of the matrix. Using ultraviolet-visible absorption spectroscopy (UV-vis) and transmission electron microscopy (TEM), we have established the reversibility of aggregation and redispersion through multiple cycles of heating and cooling.
Resolvin D1 Protects Podocytes in Adriamycin-Induced Nephropathy through Modulation of 14-3-3β Acetylation (2013)

Resolvin D1 (RvD1) is a lipid-derived mediator generated during the resolution inflammation. While the immunoresolvent effects of Resolvins have been extensively studied in leukocytes, actions of Resolvins on intrinsic kidney cells have received little attention. The podocyte plays a central role in glomerular function, and podocyte damage can lead to proteinuria and glomerulosclerosis. This study examined whether RvD1 has renoprotective effects upon podocytes. We investigated a mouse model of adriamycin (ADR) nephropathy featuring rapid induction of podocyte damage and proteinuria followed by glomerulosclerosis. We identified a progressive loss of synaptopodin expression over a 28 day time-course of ADR nephropathy which was associated with increased acetylation of 14-3-3β and reduced synaptopodin phosphorylation. Groups of mice were given once daily RvD1 treatment (4 ng/g body weight/day) starting either 30 min (early treatment) or 14 days (late treatment) after ADR injection and continued until mice were killed on day 28. Early, but not late, RvD1 treatment attenuated ADR-induced proteinuria, glomerulosclerosis and tubulointerstitial fibrosis, modified macrophages from an M1 to M2 phenotype. Early RvD1 treatment prevented the down-regulation of synaptopodin expression and changes in 14-3-3β acetylation and synaptopodin phosphorylation. In a podocyte cell line, RvD1 was shown to prevent rapid TNF-α-induced down-regulation of synaptopodin expression. In transfection studies, TNF-α-induced a decrease in synaptopodin phosphorylation and an increase in acetylation of 14-3-3β, resulting in disassociation between 14-3-3β and synaptopodin. RvD1 prevented TNF-α induced post-translational modification of synaptopodin and 14-3-3β proteins, and maintained the synaptopodin/14-3-3β interaction. Furthermore, replacement of lysine K51, or K117+K122 in 14-3-3β with glutamine, to mimic lysine acetylation, significantly reduced the interaction between 14-3-3β and synaptopodin. In conclusion, our studies provide the first evidence that RvD1 can protect against podocyte damage by preventing down-regulation of synaptopodin through inhibition of 14-3-3β/synaptopodin dissociation. RvD1 treatment may have potential application in the treatment of chronic kidney disease.
Class Distance Weighted Locality Preserving Projection for Automatic Age Estimation (2008)

We have developed new dimensionality reduction methods, extended from locality preserving projection (LPP), to estimate age using facial images. LPP seeks a linear transformation matrix such that optimally preserves the neighborhood structure of the data. Our focus has been on expanding LPP by making use of class label information. Specifically, one of our ideas is to assign weights only to the data with close class labels. A local scaling method is used for each class to compute the LPP affinity matrix. Another idea is to assign large weights to two samples with close class labels, i.e., close ages. By doing this, class label information for original data (i.e., age information) can be preserved. We thus call this "class distance weighted linear preserving projection" (CDLPP). Experimental results on a large database showed that CDLPP has more discriminative power than conventional methods such as PCA and LPP.
FACTORS ASSOCIATED WITH RESEARCH PRODUCTIVITY OF AGRICULTURAL EDUCATION FACULTY (2002)

The purpose of this study was to determine the factors that explain the research productivity of agricultural education faculty in colleges and universities. In this study, publications in refereed journals were used as a surrogate for research productivity. The study described the research productivity of agricultural education faculty, their perceptions of the organizational culture that exists in their department to support research productivity, and their self-assessment of their research competency. The population for the study included all full-time, professorial rank faculty employed by colleges and universities in the United States that offered agricultural education. In general, an organizational culture and support for research exists in the departments where the faculty work. The faculty have confidence in their ability to conduct research and reject statements that contain concerns about conducting research. The regression analysis revealed that three variables explained 50% of the variance in research productivity. These variables included number of doctoral students advised to completion in the last five years, faculty members’ perceptions of their research confidence, and the number of graduate assistant hours allocated to the faculty member. The variables that did not explain a significant proportion of the variance were percent of the faculty member’s time allocated to research, salary, organizational culture and support of research, age, gender, rank, number of master’s students advised to completion in the last five years, and number of years they had held a tenure track position.
Currents Induced in a Human Being for Plane-Wave Exposure Conditions 0-50 MHz and for RF Sealers (1986)

The currents induced in a human being were measured for plane-wave exposure conditions 0-50 MHz. These are used to point out that very large SAR's may be set up in the wet tissues for the cross section of the ankle for standing human beings exposed to electric fields suggested in the ANSI C95.1-1982 RF safety guide. For these exposure conditions, foot currents on the order of 627 mA are projected for a human adult of height 1.75 m for the frequency band 3-30 MHz with the value increasing to 780 mA for 40 MHz. The corresponding ankle-section SAR's are 182 and 243 W/kg. Using electromagnetic scaling concepts, SAR's as high as 371 and 534 W/kg are projected for ten- and five-year old children, respectively, for f = 50.7 and 62.5 MHz, E = 61.4 V/m (1 mW/cm2) recommended by the ANSI C95.1-1982 RF safety guide. The paper also gives currents induced by two sealer models and three industrial RF sealers for a human being under grounded and insulated conditions. Though smaller than those for plane-wave irradiation conditions, these currents may be substantial for high leakage fields that are quite typical.
Selective Gaseous Electro-Deposition of Lead-212 and Tellurium-208 from RdTh Source (1973)

Fractional electro-deposition of 212Pb and 208T1 from RdTh source using a capsule equipped with three electrodes was carried out under normal pressure. The experiment was conducted with variations brought to the applied voltage, the interval between the electrodes, time allowed for deposition and grid conditions. The active deposit thus obtained was examined by radiochemical and autoradiographical methods. Measurements of the active deposits on the electrodes showed that 212Pb had deposited on the grid net, and 208T1 on the target. The mechanism of the electro-deposition process under electric field with and without a grid is discussed on the basis of the decay pattern shown by each nuclide.
The Gypsy Database (GyDB) of mobile genetic elements: release 2.0 (2010)

This article introduces the second release of the Gypsy Database of Mobile Genetic Elements (GyDB 2.0): a research project devoted to the evolutionary dynamics of viruses and transposable elements based on their phylogenetic classification (per lineage and protein domain). The Gypsy Database (GyDB) is a long-term project that is continuously progressing, and that owing to the high molecular diversity of mobile elements requires to be completed in several stages. GyDB 2.0 has been powered with a wiki to allow other researchers participate in the project. The current database stage and scope are long terminal repeats (LTR) retroelements and relatives. GyDB 2.0 is an update based on the analysis of Ty3/Gypsy, Retroviridae, Ty1/Copia and Bel/Pao LTR retroelements and the Caulimoviridae pararetroviruses of plants. Among other features, in terms of the aforementioned topics, this update adds: (i) a variety of descriptions and reviews distributed in multiple web pages; (ii) protein-based phylogenies, where phylogenetic levels are assigned to distinct classified elements; (iii) a collection of multiple alignments, lineage-specific hidden Markov models and consensus sequences, called GyDB collection; (iv) updated RefSeq databases and BLAST and HMM servers to facilitate sequence characterization of new LTR retroelement and caulimovirus queries; and (v) a bibliographic server. GyDB 2.0 is available at http://gydb.org.
Steroids and Combinatorial Chemistry (2004)

ADVERTISEMENT RETURN TO ISSUEReviewNEXTSteroids and Combinatorial ChemistryRené Maltais, Martin R. Tremblay, Liviu C. Ciobanu, and Donald PoirierView Author Information Medicinal Chemistry Division, Oncology and Molecular Endocrinology Research Center, Centre Hospitalier Universitaire de Québec (CHUQ)-Pavillon CHUL and Université Laval, Sainte-Foy, Québec G1V 4G2, Canada Cite this: J. Comb. Chem. 2004, 6, 4, 443–456Publication Date (Web):May 13, 2004Publication History Received23 September 2003Published online13 May 2004Published inissue 1 July 2004https://pubs.acs.org/doi/10.1021/cc030118mhttps://doi.org/10.1021/cc030118mreview-articleACS PublicationsCopyright © 2004 American Chemical SocietyRequest reuse permissionsArticle Views1010Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options SUBJECTS:Alcohols,Organic polymers,Reaction products,Receptors,Steroids Get e-Alerts
Echocardiographic detection of stfess-induced myocardial ischemia using quantitative analysis of contrast-enhanced parametric perfusion images (2005)

Echocardiographic assessment of myocardial perfusion is currently achieved by measuring indices of contrast replenishment following destructive high-energy ultrasound impulses @ask-echo), We developed a technique for automated detection of perfusion defects based on quanritative analysis of parametric pelfusion images created from these indices. Parametric images were obtained a[ rest and during dipyridamole stress in 18 pts with suspected coronary artery disease. Each image was divided into 6 segments, and mean parameter value (MPV) was calculated for each segment. Changes in MPV from rest to stress were used to automatically detect stress-induced pe&sion defects. ROC analysis was used to optimize (1) the threshold for MPV stress-to-rest ratio, and (2) the minimal number of abnormal segments, required for the diagnosis of ischemia, using coronary stenosis > 70% as rhe "gold standard". The sensitivity, specificity and accuracy of the automated detection of ischemia were 63, 75 and 69% in the LAD, and 67,100 and 75% in the non-LAD territories. In conclusion, automated quantitative analysis of echocardiographic porumetric perjfusion images is feasible and m y be useful for objective detection of myocardial ischemia.
Optimization of anti‐reflection moth‐eye structures for use in crystalline silicon solar cells (2010)

Abstract An anti‐reflection (AR) moth‐eye structure made of acrylic resin and deposited on a polyethylene terephthalate (PET) substrate was optimized in the wavelength range from 400 to 1170 nm; crystalline silicon (c‐Si) solar cells function efficiently in this wavelength range. The rigorous coupled wave analysis (RCWA) method was used for optical simulation, and the Taguchi method was used for efficient optimization. The simulation results showed that the reflectance of the optimized structure over the above‐mentioned wavelength range was less than 0.87% and that a minimal reflectance of 0.1% was observed at 400 nm. Experimental results showed that the reflectance of a fabricated moth‐eye structure was less than 1.0% in the wavelength range and that a minimal reflectance of 0.55% was observed at 700 nm. A c‐Si solar cell, which was enclosed in a polyvinyl butyral (PVB) layer of uniform thickness, was coated with the fabricated moth‐eye film, and it was observed that the moth‐eye film increased electric generation (EG) up to 15%, depending on the incident angle. Further, a daily increase in EG of up to 8.7% was estimated on a clear summer day in Japan when the moth‐eye film was used. Copyright © 2010 John Wiley & Sons, Ltd.
Resveratrol inhibits human lung adenocarcinoma cell metastasis by suppressing heme oxygenase 1‐mediated nuclear factor‐κB pathway and subsequently downregulating expression of matrix metalloproteinases (2010)

Resveratrol exhibits potential anti-carcinogenic activities. Heme oxygenase-1 (HO-1) is involved in angiogenesis and tumor metastasis. Matrix metalloproteinases (MMPs) are key enzymes in the degradation of extracellular matrix, and their expression may be dysregulated in lung cancer metastasis. In this study, we investigated the anti-invasive mechanism of resveratrol in lung cancer cells. HO-1 was shown to be elevated (approximately 4.7-fold) in lung cancer tumor samples as compared with matched normal tissues. After treatment of lung adenocarcinoma cell line A549 cells with resveratrol (50 microM) for 24 h, the migratory and invasive abilities (38 and 30% inhibition, respectively) of A549 cells were significantly reduced. Resveratrol significantly inhibited HO-1-mediated MMP-9 (35% inhibition) and MMP-2 (28% inhibition) expression in lung cancer cells. Nuclear factor (NF)-kappaB inhibitor induced a marked reduction in MMP-9 and MMP-2 expression, suggesting NF-kappaB pathway could play an important role. Furthermore, HO-1 inhibition and silencing significantly suppressed MMPs and invasion of lung cancer cells. Our results suggest that resveratrol inhibited HO-1 and subsequently MMP-9 and MMP-2 expression in lung cancer cells. The inhibitory effects of resveratrol on MMP expression and invasion of lung cancer cells are, in part, associated with the HO-1-mediated NF-kappaB pathway.
Effects of Chilling Time and Belt Flattening on Physical Characteristics, Yield and Tenderness of Broiler Breasts (1997)

Removing the large breast muscle from broiler carcasses prior to the resolution of rigor mortis results in tough cooked meat. However, the practice of holding carcasses or front halves 8 to 24 hr after chilling prior to deboning to ensure tenderness in the cooked meat is costly with regard to refrigerated space, equipment, and labor. This study determined the effect of extending the chilling time (1, 2, or 3 hr) and subjecting the deboned breast muscles to belt flattening on subsequent physical dimensions (length and width), yield, and tenderness of the cooked meat. Maximum length, width, and weight of each muscle were recorded before and after flattening, and cooked yield and objective texture (tenderness) were evaluated to determine if a combination of the two treatments would eliminate the need to age carcasses for prolonged times prior to deboning. For objective texture, increasing the chilling time resulted in less force necessary to shear the cooked meat, and flattened breasts required less force to shear than did the unflattened breasts. Belt flattening resulted in a loss in weight and an increase in surface area (length and width) of the raw muscle. The combination of carcass chilling for 2 hr followed by belt flattening resulted in cooked meat that would be considered “very tender.”
Noncollinear phase matching in GaAs (1973)

Noncollinear mixing in GaAs has been used to obtain phase-matched generation of the far-infrared difference-frequency radiation at 100.8 cm−1 with TEA CO2 lasers.