gebhart/patrepeval huggingface dataset:
The Effect of Dietary Sargassum natans and Ascophyllum nodosum on Salmonella gallinarum Infection in Chicks (1968)

MARTINEZ Nadal et al. (1964, 1965) reported the presence of antibiotic substances in extracts of the brown alga, Sargassum natans, as well as the red alga, Chondria littoralis, and the green alga, Cymopolia barbata. Among the organisms affected in vitro by these substances was Salmonella gallinarum, the causative agent of fowl typhoid. The studies presented in this report were undertaken to determine whether the inclusion of Sargassum natans in the diet of chicks would affect the outcome of an infection with S. gallinarum. MATERIALS AND METHODS The chicks used in these studies were White Plymouth Rocks obtained from a commercial hatchery. The diet used was based on soybean meal and corn. The composition is presented in Table 1. Two lots of 20 chicks each were fed each diet. In the first experiment the diets were fed from the day of hatching, and in the second experiment they were fed from . . .
Inflammation in Neurological Disorders: A Help or a Hindrance? (2010)

Inflammation of the central nervous system (CNS) (neuroinflammation) is now recognized to be a feature of all neurological disorders. In multiple sclerosis, there is prominent infiltration of various leukocyte subsets into the CNS. Even when there is no significant inflammatory infiltrates, such as in Parkinson or Alzheimer disease, there is intense activation of microglia with resultant elevation of many inflammatory mediators within the CNS. An extensive dataset describes neuroinflammation to have detrimental consequences, but results emerging largely over the past decade have indicated that aspects of the inflammatory response are beneficial for CNS outcomes. Benefits of neuroinflammation now include neuroprotection, the mobilization of neural precursors for repair, remyelination, and even axonal regeneration. The findings that neuroinflammation can be beneficial should not be surprising as a properly directed inflammatory response in other tissues is a natural healing process after an insult. In this article, we review the data that highlight the dual aspects of neuroinflammation in being a hindrance on the one hand but also a significant help for recovery of the CNS on the other. We consider how the inflammatory response may be beneficial or injurious, and we describe strategies to harness the beneficial aspects of neuroinflammation.
IL6-STAT3-HIF Signaling and Therapeutic Response to the Angiogenesis Inhibitor Sunitinib in Ovarian Clear Cell Cancer (2011)

Our findings highlight important therapeutic targets in OCCA, suggest that more extensive clinical trials with sunitinib in OCCA are warranted, and provide significant impetus to the growing realization that OCCA is molecularly and clinically distinct to other forms of ovarian cancer.
The Carboxyterminal Peptide of Chorionic Gonadotropin Facilitates Activation of the Marmoset LH Receptor (2004)

Luteinizing hormone (LH) and chorionic gonadotropin (CG) are heterodimeric glycoprotein hormones acting on the luteinizing hormone receptor (LHR). In the LHR, which is genomically encoded by eleven exons, exon 10 encodes for the hinge region and its elimination impairs LH action, while CG maintains normal activity. The two gonadotropins differ in the carboxyterminal peptide (CTP) present in CG but absent in LH. Since the marmoset monkey (Callithrix jacchus) LHR naturally lacks exon 10 (LHR type II), we generated two recombinant marmoset gonadotropin preparations, one consisting of the wild type CG and one of truncated CG lacking the CTP (CG (-CTP)). After calibration in a mouse Leydig cell bioassay against the WHO LH80/522 standard, the ED (50) of the CG preparation on a COS7 cell line permanently expressing the marmoset LHR was 4.25 +/- 0.21 IU/L (n = 3). Stimulation of the COS7 cell line with equipotent concentrations of CG and CG (-CTP) resulted in significantly different formation of cAMP (two-way ANOVA, p < 0.001). In particular, cAMP production stimulated by CG (-CTP) was 3 - 4 times lower compared to CG at the saturating CG concentration (8 IU/L). We conclude, supplementing one current model of LHR activation, that exon 10 might play a permissive role in releasing the constraint of the receptor upon hormone binding, resulting in receptor activation. We speculate that, when exon 10 is lacking, the CTP can overcome its absence and facilitates the opening of the receptor, resulting in normal activation.
Receiver-driven bandwidth sharing for TCP and its application to video streaming (2005)

Applications using Transmission Control Protocol (TCP), such as web-browsers, ftp, and various peer-to-peer (P2P) programs, dominate most of the Internet traffic today. In many cases, users have bandwidth-limited last mile connections to the Internet which act as network bottlenecks. Users generally run multiple concurrent networking applications that compete for the scarce bandwidth resource. Standard TCP shares bottleneck link capacity according to connection round-trip time (RTT), and consequently may result in a bandwidth partition which does not necessarily coincide with the user's desires. In this work, we present a receiver-based bandwidth sharing system (BWSS) for allocating the capacity of last-hop access links according to user preferences. Our system does not require modifications to the TCP protocol, network infrastructure or sending hosts, making it easy to deploy. By breaking fairness between flows on the access link, the BWSS can limit the throughput fluctuations of high-priority applications. We utilize the BWSS to perform efficient video streaming over TCP to receivers with bandwidth-limited last mile connections. We demonstrate the effectiveness of our proposed system through Internet experiments.
Bone Marrow Mesenchymal Stem Cells from Healthy Donors and Sporadic Amyotrophic Lateral Sclerosis Patients (2008)

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease lacking effective therapies. Cell replacement therapy has been suggested as a promising therapeutic approach for multiple neurodegenerative diseases, including motor neuron disease. We analyzed expanded mesenchymal stem cells (MSCs) isolated from sporadic ALS patients and compared them with MSCs isolated from healthy donors. MSCs were isolated from bone marrow by Percoll gradient and maintained in culture in MSC Medium until the third passage. Growth kinetics, immunophenotype, telomere length, and karyotype were evaluated during in vitro expansion. Osteogenic, adipogenic, chondrogenic, and neurogenic differentiation potential were also evaluated. No morphological differences were observed in the MSCs isolated from donors or patients. The cellular expansion potential of MSCs from donors and patients was slightly different. After three passages, the MSCs isolated from donors reached a cumulative population doubling higher than from patients but the difference was not statistically significant. No significant differences between donors or patients were observed in the immunophenotype analysis. No chromosomal alteration or evidence of cellular senescence was observed in any samples. Both donor and patient MSCs, after exposure to specific conditioning media, differentiated into adipocytes, osteoblasts, chondrocytes, and neuron-like cells. These results suggest that extensive in vitro expansion of patient MSCs does not involve any functional modification of the cells, including chromosomal alterations or cellular senescence. Hence, there is a good chance that MSCs might be used as a cell-based therapy for ALS patients.
Navstar Global Positioning System: Progress Report (1987)

All three segments of the GPS, space, control, and user equipment, are now in production. Extensive testing during Phase I and II of the program has proven that the GPS provides a quantum improvement over the capabilities of existing navigational systems and significant mission enhancement in a broad range of military operations. Production of the Block II satellites is progressing on schedule, but the space shuttle accident will delay completion of the full constellation by about two years. The Control Segment is fully operational and will transition to Space Command in 1987. The user equipment will enter production and undergo further testing during the LRIP period to ensure that service operational effectiveness and suitability requirements are met before commencing full-rate production. The GPS should be fully operational in the early 1990's and will provide a powerful force enhancer for all the military services for many years to come.
Heat‐Integrated Reactor Concepts for Hydrogen Production by Methane Steam Reforming (2005)

Abstract Steam reforming of hydrocarbons is the major source of hydrogen on an industrial scale. Conventional, large scale, processes for hydrogen production are not optimal for the decentralized, stand‐alone supply of hydrogen for fuel cell systems. Their major drawback is limited thermal efficiency due to restricted heat recovery from the reformer effluents. A promising approach to overcome these limitations is the utilization of multifunctional reactor concepts, integrating the major reaction steps and process heat management. Coupling endothermic and exothermic reactions into heat‐integrated processes can be realized in different ways. One possible design is based on micro‐structured devices employing recuperative heat exchange between the process streams. A comparable specific performance and functionality can be achieved with adiabatic fixed‐bed reactors, operating in a transient mode. A major issue for both alternatives is the proper axial distribution of the process heat. Novel design solutions, developed in our group, are reviewed in this paper. Detailed simulation studies, as well as proof‐of‐concept experiments, confirm their feasibility and potential to significantly enhance the efficiency of the process.
Quantitative metabolic profiling of urinary organic acids by gas chromatography-mass spectrometry. Comparison of isolation methods (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTQuantitative metabolic profiling of urinary organic acids by gas chromatography-mass spectrometry. Comparison of isolation methodsJohn A. Thompson and Sanford P. MarkeyCite this: Anal. Chem. 1975, 47, 8, 1313–1321Publication Date (Print):July 1, 1975Publication History Published online1 May 2002Published inissue 1 July 1975https://doi.org/10.1021/ac60358a074RIGHTS & PERMISSIONSArticle Views490Altmetric-Citations128LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (972 KB) Get e-Alerts Get e-Alerts
Dauricine induces apoptosis, inhibits proliferation and invasion through inhibiting NF‐κB signaling pathway in colon cancer cells (2010)

Dauricine, a bioactive component of Asiatic Moonseed Rhizome, has been widely used to treat a large number of inflammatory diseases in traditional Chinese medicine. In our study, we demonstrated that dauricine inhibited colon cancer cell proliferation and invasion, and induced apoptosis by suppressing nuclear factor-kappaB (NF-kappaB) activation in a dose- and time-dependent manner. Addition of dauricine inhibited the phosphorylation and degradation of IkappaBalpha, and the phosphorylation and translocation of p65. Moreover, dauricine down-regulated the expression of various NF-kappaB-regulated genes, including genes involved cell proliferation (cyclinD1, COX2, and c-Myc), anti-apoptosis (survivin, Bcl-2, XIAP, and IAP1), invasion (MMP-9 and ICAM-1), and angiogenesis (VEGF). In athymic nu/nu mouse model, we further demonstrated that dauricine significantly suppressed colonic tumor growth. Taken together, our results demonstrated that dauricine inhibited colon cancer cell proliferation, invasion, and induced cell apoptosis by suppressing NF-kappaB activity and the expression profile of its downstream genes. These findings provide evidence for a novel role of dauricine in preventing or treating colon cancer through modulation of NF-kappaB singling pathway.
Society and Andrew Marvell (1997)

At first sight the poetry of Andrew Marvell seems to bear little relation to the age in which he lived. Marvell wrote a good deal of political satire, which is of considerable interest to the historian, but of less poetic value; his greatest poems (except the 'Horatian Ode upon Cromwel's return from Ireland') have no direct reference to the political and social revolution of the seventeenth century. Yet this revolution transformed the lives of Englishmen; it faced them with intellectual and moral decisions which it was difficult to evade. I believe that if we study Marvell with a knowledge of the political background of his life we can discover in the great lyrics new complexities which will increase our appreciation of those very sensitive and civilized poems.
Metal Complexes of Schiff Bases: Preparation, Characterization, and Biological Activity (2006)

Metal complexes of Schiff bases derived from 2-furancarboxaldehyde and o-phenylenediamine (L1), and 2-thiophenecarboxaldehyde and 2-aminothiophenol (HL2) are reported and characterized based on elemental analyses, IR 1H NMR, solid reflectance, magnetic moment, molar conductance, and thermal analysis (TGA). The ligand dissociation, as well as the metal-ligand stability constants were calculated, pH-metrically, at 25 °C and ionic strength m = 0.1 (1 M NaCl). The complexes are found to have the formulae [M(L1)(H2O)2](Cl)n \\cdot yH2O (where M = Fe(III), Ni(II), Cu(II); n = 2-3, y = 2-4); [M(L1)](X)2 \\cdot yH2O (where M = Co(II), Zn(II), UO2(II), X = Cl, AcO or NO3, y = 1-3); [M(L2)2] \\cdot yH2O (where M = Co(II), Ni(II), Cu(II); X = Cl; y = 0-2 and Zn(II); X = AcO, y = 0); and [Fe(L2)2]Cl \\cdot 2H2O and [UO2(HL2)2](NO3)2. The molar conductance data reveal that all the metal chelates of the L1 ligand, and Fe(III) and UO2(II) chelates of HL2 are electrolytes, while Co(II), Ni(II), Cu(II), and Zn(II) chelates of HL2 are non-electrolytes. IR spectra show that L1 is coordinated to the metal ions in a tetradentate manner, with ONNO donor sites of azomethine--N and furan-O, whereas the HL2 ligand is coordinated to the metal ions in a terdentate manner with SNS donor sites of azomethine--N, thiophene-S, and thiol-S. From the magnetic and solid reflectance spectra, it is found that the geometrical structures of these complexes are octahedral and tetrahedral. The thermal behavior of these chelates shows that the hydrated complexes lose water molecules of hydration in the first step and is immediately followed by decomposition of the anions and ligand molecules in the subsequent steps. The activation thermodynamic parameters, such as E*, D H*, D S*, and D G*, are calculated from the DrTG curves using the Coats-Redfern method. The synthesized ligands, in comparison to their metal complexes, were also screened for their antibacterial activity against bacterial species, Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus Pyogones, as well as fungi (Candida). The activity data show the metal complexes to be more potent antibacterials than the parent Schiff base ligand against one or more bacterial species.
A new gsc using monopulse angle estimation technique for fast target tracking (2004)

A new generalized sidelobe canceller (GSC) is proposed to solve the steering error problem caused by fast target maneuvering or array imperfections. The proposed GSC uses the monopulse technique to identify the steering error. Seperate sum and different channels are used for estimating the monopulse ratio. While interferences are removed by adaptive beamforming, fixed-weight sum and difference beampattems are applied to estimate the steering error. Simulation results show that the proposed GSC can solve the steering error and track the target even under severe jamming conditions.
Three-dimensional Hybrid-PIC Simulation of Microwave Neutralizer (2013)

In order to analyze a microwave neutralizer in ion's time/space scales, weakly coupled simulations of a Hybrid-PIC (Particle-In-Cell) and an electromagnetic PIC simulation were conducted. The ionization rate with respect to microwave discharge was obtained from the electromagnetic PIC solver, and was exported to the Hybrid-PIC where ions and electrons were dealt with particles and fluid, respectively. Two anode potentials of 20 and 38 V were examined to simulate a transition from a low current mode to a high current mode. The electron temperature inside an orifice was fixed to 3 eV at the low current mode, and was artificially increased to 4 eV at the higher anode potential of 38 V. It was found that the grown ion density inside the orifice at the high current mode leads to increase in the ion density around the antenna, and hence to increase in ion production rate by microwave discharge. As a result, the electron current collected by the virtual anode was increased from 22 mA to 98 mA.
Anticancer activities of orally administered menogaril against human stomach and breast cancers implanted in nude mice. (1993)

The therapeutic effects of orally administered menogaril, a semisynthetic analog of the anthracycline antibiotic nogalamycin, were studied on a panel of human stomach and breast cancer xenografts. The maximum tolerated dose (200 mg/kg) of menogaril was administered 3 times every 4 days and its growth-inhibitory effects on subcutaneously implanted tumors in nude mice were evaluated. Menogaril significantly retarded the growth of 3 out of 7 stomach cancers, SC-2, SC-9 and 4-1ST, and 3 out of 4 breast cancers, H-31, MC-2 and MX-1, with overall response rates of 43 and 75% for stomach and breast cancers, respectively. Some of these relatively responsive cancers were also treated by daily oral administration for 5 consecutive days, but the anticancer effects of the intermittent administration seemed to be better. These results suggest that menogaril may be effective against stomach and breast cancers when orally administered.
Marketplace success factors for new financial services (1993)

Examines the effects of service offered on the success of new customer financial services in the United Kingdom. Shows that previous research has concentrated on the new product process ignoring what are termed direct factors (characteristics that affect the interaction between the service offered and the consumer). Finds that a number of characteristics describing the service core and the augmented service offering are highly correlated with success.
Proton NMR spectroscopic studies of calcium-binding proteins. 3. Solution conformations of rat apo-.alpha.-parvalbumin and metal-bound rat .alpha.-parvalbumin (1986)

Lacking the extraordinary thermal stability of its metal-bound forms, apo-alpha-parvalbumin from rat muscle assumes two distinct conformations in aqueous solution. At 25 degrees C, its highly structured form predominates (Keq = 5.7; delta G degree = -4.3 kJ X mol-1); as deduced from both 1H NMR and circular dichroism (CD) spectroscopy, this conformation is exceedingly similar to those of its Mg(II)-, Ca(II)-, and Lu(III)-bound forms. The temperature dependences of several well-resolved aromatic and upfield-shifted methyl 1H NMR resonances and several CD bands indicate that the native, highly helical structure of rat apo-alpha-parvalbumin is unfolded by a concerted mechanism, showing no indication of partially structured intermediates. The melting temperature, TM, of rat apo-alpha-parvalbumin is 35 +/- 0.5 degrees C as calculated by both spectroscopic techniques. By 45 degrees C, rat apo-alpha-parvalbumin unfolds entirely, losing the tertiary structure that characterizes its folded form: not only are the ring-current-shifted aromatic and methyl 1H NMR resonances leveled, but the 262- and 269-nm CD bands are also severely reduced. As judged by the decrease in the negative ellipticity of the 222-nm CD band, this less-structured form of rat apo-alpha-parvalbumin shows an approximate 50% loss in apparent alpha-helical content compared to its folded state. Several changes in the 1H NMR spectrum of rat apo-alpha-parvalbumin were exceptionally informative probes of the specific conformational changes that accompany metal ion binding and metal ion exchange. In particular, the line intensities of the ortho proton resonance of Phe-47, the unassigned downfield-shifted alpha-CH resonances from the beta-sheet contacts between the metal-binding loops, the C2H resonance of His-48, and the epsilon-CH3 resonance of an unassigned Met residue were monitored as a function of added metal to determine the stability constants of several metal ion-parvalbumin complexes. We conclude that Mg(II) binds to the CD and EF sites independently, its affinity for the EF site being almost twice that for the CD site. Mg(II)----Ca(II) exchange showed that the CD-site Mg(II) is displaced first, in contrast to Lu(III)'s preferential displacement of the EF-site Ca(II) as determined from the Ca(II)----Lu(III) exchange experiments.(ABSTRACT TRUNCATED AT 400 WORDS)
From Qinghao, Marvelous Herb of Antiquity, to the Antimalarial Trioxane Qinghaosuand Some Remarkable New Chemistry (1997)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFrom Qinghao, Marvelous Herb of Antiquity, to the Antimalarial Trioxane Qinghaosuand Some Remarkable New ChemistryRichard K. Haynes and Simone C. VonwillerView Author Information Department of Chemistry, Hong Kong University of Science and Technology, Kowloon, Hong Kong, and School of Chemistry, University of Sydney, New South Wales 2006, AustraliaCite this: Acc. Chem. Res. 1997, 30, 2, 73–79Publication Date (Web):February 13, 1997Publication History Received17 September 1996Published online13 February 1997Published inissue 1 February 1997https://pubs.acs.org/doi/10.1021/ar950058whttps://doi.org/10.1021/ar950058wresearch-articleACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views757Altmetric-Citations193LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Antimicrobial agents,Crystal cleavage,Oxides,Oxygen,Reaction products Get e-Alerts