gebhart/patrepeval huggingface dataset:
Actinin-4, a Novel Actin-bundling Protein Associated with Cell Motility and Cancer Invasion (1998)

Regulation of the actin cytoskeleton may play a crucial role in cell motility and cancer invasion. We have produced a monoclonal antibody (NCC- Lu-632, IgM, k) reactive with an antigenic protein that is upregulated upon enhanced cell movement. The cDNA for the antigen molecule was found to encode a novel isoform of nonmuscle alpha-actinin. This isoform (designated actinin-4) was concentrated in the cytoplasm where cells were sharply extended and in cells migrating and located at the edge of cell clusters, but was absent from focal adhesion plaques or adherens junctions, where the classic isoform (actinin-1) was concentrated. Actinin-4 shifted steadily from the cytoplasm to the nucleus upon inhibition of phosphatidylinositol 3 kinase or actin depolymerization. The cytoplasmic localization of actinin-4 was closely associated with an infiltrative histological phenotype and correlated significantly with a poorer prognosis in 61 cases of breast cancer. These findings suggest that cytoplasmic actinin-4 regulates the actin cytoskeleton and increases cellular motility and that its inactivation by transfer to the nucleus abolishes the metastatic potential of human cancers.
Immunization with a DNA Plasmid Encoding the SAG1 (P30) Protein of<i>Toxoplasma gondii</i>Is Immunogenic and Protective in Rodents (2000)

Immunization with DNA can induce humoral and cell-mediated immune responses, both of which are important in conferring immunity to Toxoplasma gondii. The efficacy of genetic vaccination with a cDNA encoding the T. gondii SAG1 (P30) surface antigen was evaluated. Sera of immunized mice showed recognition of T. gondii tachyzoites by immunofluorescence and exhibited high titers of antibody to SAG1 by ELISA. SAG1-stimulated splenocytes from vaccinated mice produced primarily interferon-gamma and interleukin-2. Vaccinated mice survived challenge with 80 tissue cysts of ME49 strain, whereas all control mice died; challenge with 20 tissue cysts resulted in fewer brain cysts, compared with controls. Challenge of vaccinated rats with VEG strain oocysts resulted in a reduction in brain cysts. No protection was observed when mice were challenged with the highly virulent RH strain tachyzoites. These results suggest that nucleic acid vaccination can provide protection against T. gondii infection in mice.
Multifactor authentication system based on biometrics and radio frequency identification (2016)

Nowadays identification systems is being used in applications where security is required. However, the authentication with one layer of protection is obsolete. This fact causes that new threatens have appeared and that the number of attempts to break different systems has increased. In this paper, we propose a multifactor authentication system. During the authentication process, several validation factors may be needed to verify the user's identity. The goal is to perform an integrated application by layers such as biometrics and radio frequency identification (RFID). Based on this concept, the proposed method has an authentication engine with two independent credentials where an instrumentation system with an infrared LED and photodiode has been developed to evaluate fake fingerprints.
2D marine controlled-source electromagnetic modeling: Part 1 — An adaptive finite-element algorithm (2007)

Abstract In Part 1 of this work, we develop an adaptive finite-element algorithm for forward modeling of the frequency-domain, marine controlled-source electromagnetic (CSEM) response of a 2D conductivity structure that is excited by a horizontal electric dipole source. After transforming the governing equations for the secondary electromagnetic fields into the wavenumber domain, the coupled system of two partial differential equations for the strike-parallel electric and magnetic fields is approximated using the finite-element method. The model domain is discretized using an unstructured triangular element grid that readily accommodates arbitrarily complex structures. A numerical solution of the system of linear equations is obtained using the quasi-minimal residual (QMR) method, which requiresmuch less storagethan full matrix inversion methods. We implement an automatedadaptive grid refinement algorithm in which the finite-element solution is computed iteratively on successively refined grids. Grid refinement is guided by an a posteriori error estimator based on a recently developed gradient recovery operator. The error estimator uses the solution to a dual problem in order to bias refinement toward elements that affect the solution at the electromagnetic (EM) receiver locations and enables the computation of asymptotically exact solutions to the 2.5D partial differential equations. We validate the finite element formulation against the canonical 1D reservoir model and study the performance of the adaptive refinement algorithm. An example model study of a complex offshore structure of interest for petroleum exploration illustrates the utility of the adaptive finite-element method for CSEM modeling.
Tropical yams and their potential (1974)

Tropical yams and their potential , Tropical yams and their potential , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی
The Host Cell Sulfonation Pathway Contributes to Retroviral Infection at a Step Coincident with Provirus Establishment (2008)

The early steps of retrovirus replication leading up to provirus establishment are highly dependent on cellular processes and represent a time when the virus is particularly vulnerable to antivirals and host defense mechanisms. However, the roles played by cellular factors are only partially understood. To identify cellular processes that participate in these critical steps, we employed a high volume screening of insertionally mutagenized somatic cells using a murine leukemia virus (MLV) vector. This approach identified a role for 3'-phosphoadenosine 5'-phosphosulfate synthase 1 (PAPSS1), one of two enzymes that synthesize PAPS, the high energy sulfate donor used in all sulfonation reactions catalyzed by cellular sulfotransferases. The role of the cellular sulfonation pathway was confirmed using chemical inhibitors of PAPS synthases and cellular sulfotransferases. The requirement for sulfonation was mapped to a stage during or shortly after MLV provirus establishment and influenced subsequent gene expression from the viral long terminal repeat (LTR) promoter. Infection of cells by an HIV vector was also shown to be highly dependent on the cellular sulfonation pathway. These studies have uncovered a heretofore unknown regulatory step of retroviral replication, have defined a new biological function for sulfonation in nuclear gene expression, and provide a potentially valuable new target for HIV/AIDS therapy.
Psoriasis: rationale for targeting interleukin-17 (2012)

The exact pathogenesis of plaque psoriasis remains to be fully determined, but it is thought to depend on environmental and genetic factors that stimulate dysregulated innate and adaptive immune responses in the skin. The cytokine interleukin (IL)-17A plays a key role in host defence against extracellular bacteria and fungi. An increasing body of evidence suggests that IL-17A is also important in psoriasis pathogenesis. While IL-17A is a key product of Th17 cells, it is also produced by neutrophils, mast cells and Tc17 cells. Each of these cell types is found in psoriatic lesions. IL-17A acts on keratinocytes to increase expression of chemokines (e.g. CCL20, CXCL1, CXCL3, CXCL5, CXCL6 and CXCL8) involved in recruiting myeloid dendritic cells, Th17 cells and neutrophils to the lesion site. IL-17A induces production of antimicrobial peptides and proinflammatory cytokines that, in turn, may help sustain immune responses in the skin. Blocking IL-17A improved psoriasis-like pathology in experimental models, and reductions in IL-17 signalling have been associated with response to tumour necrosis factor-α blockers in patients with psoriasis. Agents that inhibit IL-17 are in development and preliminary clinical results for IL-17 inhibitors indicate the importance of IL-17A in psoriasis pathophysiology. In a proof-of-concept and two phase II trials, three agents markedly reduced disease severity in patients with moderate-to-severe plaque psoriasis. One agent downregulated cytokines, chemokines and proteins associated with inflammatory responses in lesional skin. In summary, IL-17A is an attractive therapeutic target, which may allow selective intervention to address the dysregulated immune system in plaque psoriasis.
Dynamic SPECT of the brain using a lipophilic technetium-99m complex, PnAO. (1985)

The lipophilic 99mTc-labeled oxime propylene amine oxime (PnAO) should, according to recent reports behave like 133Xe in the human brain. This study compares SPECT images of the two tracers in six subjects: four stroke cases, one transitory ischemic attack case and one normal subject. Technetium-99m PnAO was injected i.v. as a bolus of 15 to 25 mCi. The distribution was followed over 10-sec intervals using a highly sensitive, rapidly rotating SPECT (Tomomatic 64) and compared to 133Xe flow maps. Upon arrival of the PnAO bolus to the brain, a high uptake was found in brain tissue with high cerebral blood flow followed by rapid washout. In the stroke cases, low flow areas were equally well visualized by both tracers. Two dissimilarities were seen in the initial pictures: PnAO visualized the cerebral veins and showed a lesser contrast of gray:white matter uptake. The results suggest that PnAO has a high yet incomplete brain extraction yielding a flow dominated initial distribution with limitations mentioned.
Quantitative evaluation of the electromyographic responses to multidirectional load perturbations of the human arm (1988)

1. Force perturbations consisting of a random train of pulses were applied to the forearms of human subjects, the direction of the force being varied +/- 60 degrees from vertical in the sagittal plane in different trials. 2. Both forearm and upper arm were free to move, and the perturbations resulted in angular motion and torque at both joints. By varying the direction of the force, different combinations of these variables could be obtained. 3. Average angular motion and net torque at the shoulder and elbow joints and electromyographic activity of shoulder and elbow muscles due to a single pulse of force were computed by cross-correlation methods. 4. The pattern of responses in biceps, brachio-radialis, and anterior deltoid was not related uniquely to angular motion at the shoulder or elbow joints. Furthermore, the responses appeared to consist of two distinct components, an "early" one with a latency less than 40 ms and a "late" one with a latency of approximately 80 ms. 5. The average amplitude of the early response was best correlated with the average change in angular velocities, whereas that of the late one was best correlated with average changes in torque resulting from the perturbation. The data are consistent with the hypothesis that the two components have different anatomical substrates and that they have different functional implications for the stabilization of the limb in the face of perturbations.
Design of IIR filters (2011)

Master the basic concepts and methodologies of digital signal processing with this systematic introduction, without the need for an extensive mathematical background. The authors lead the reader through the fundamental mathematical principles underlying the operation of key signal processing techniques, providing simple arguments and cases rather than detailed general proofs. Coverage of practical implementation, discussion of the limitations of particular methods and plentiful MATLAB illustrations allow readers to better connect theory and practice. A focus on algorithms that are of theoretical importance or useful in real-world applications ensures that students cover material relevant to engineering practice, and equips students and practitioners alike with the basic principles necessary to apply DSP techniques to a variety of applications. Chapters include worked examples, problems and computer experiments, helping students to absorb the material they have just read. Lecture slides for all figures and solutions to the numerous problems are available to instructors.
Link contexts in classifier-guided topical crawlers (2006)

Context of a hyperlink or link context is defined as the terms that appear in the text around a hyperlink within a Web page. Link contexts have been applied to a variety of Web information retrieval and categorization tasks. Topical or focused Web crawlers have a special reliance on link contexts. These crawlers automatically navigate the hyperlinked structure of the Web while using link contexts to predict the benefit of following the corresponding hyperlinks with respect to some initiating topic or theme. Using topical crawlers that are guided by a support vector machine, we investigate the effects of various definitions of link contexts on the crawling performance. We find that a crawler that exploits words both in the immediate vicinity of a hyperlink as well as the entire parent page performs significantly better than a crawler that depends on just one of those cues. Also, we find that a crawler that uses the tag tree hierarchy within Web pages provides effective coverage. We analyze our results along various dimensions such as link context quality, topic difficulty, length of crawl, training data, and topic domain. The study was done using multiple crawls over 100 topics covering millions of pages allowing us to derive statistically strong results.
High-speed InP-InGaAs heterojunction phototransistors employing a nonalloyed electrode metal as a reflector (1994)

High-speed InP-InGaAs heterojunction phototransistors (HPT's) with a base terminal (three-terminal HPT's) have been fabricated. These HPT's have nonalloyed electrodes functioning as reflectors and a configuration in which light is incident through the substrate. These features lead to an increase in quantum efficiency in spite of the thin base and collector light-absorbing layers. Optical gain dependence on collector current is weak because of the low recombination current at the emitter-base interface. Maximum optical-gain cutoff frequencies of 22 and 14 GHz are obtained for a 3/spl times/3-/spl mu/m/sup 2/ emitter HPT illuminated by 1.3- and 1.55-/spl mu/m light, respectively. This HPT has the capability of operating as a high-speed heterojunction bipolar transistor (HBT) as well. A current-gain cutoff frequency (f/sub T/) of 128 GHz is obtained for a 3/spl times/9-/spl mu/m/sup 2/ emitter HBT fabricated on the same wafer. Equivalent circuit analysis, in which all the components are determined by measuring both the electrical and optical characteristics of a three-terminal HPT, shows good agreement with experimental results.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
NUTRITIONAL FACTORS IN DENTAL CARIES AND PARODONTAL DISEASE (1944)

NUTRITIONAL FACTORS IN DENTAL CARIES AND PARODONTAL DISEASE Get access J. D. KING, PH.D., D.P.D, L.D.S. J. D. KING, PH.D., D.P.D, L.D.S. Nutrition Building, National Institute for Medical ResearchLondon Search for other works by this author on: Oxford Academic PubMed Google Scholar British Medical Bulletin, Volume 2, Issue 10-11, 1944, Pages 222–225, https://doi.org/10.1093/oxfordjournals.bmb.a071043 Published: 01 October 1944
Catalytic Polymerization of a Cyclic Ester Derived from a “Cool” Natural Precursor (2005)

(-)-Menthide, a seven-membered lactone derived from the natural product (-)-menthol, was polymerized using a structurally defined zinc-alkoxide catalyst to form an aliphatic polyester. The polymer was fully characterized by NMR spectroscopy, size exclusion chromatography, and matrix-assisted laser desorption ionization mass spectrometry. The polymerization reaction occurred in a controlled fashion and polymer samples with M(n) values up to 90 kg mol(-1) were obtained by varying the catalyst loading. Monitoring of the rate of polymerization by in situ FT-IR spectroscopy (ReactIR) revealed a first order dependence on (-)-menthide. The temperature dependence of the observed rate constant between 30 and 90 degrees C was well described by the Arrhenius equation and gave E(a) = 38.4 +/- 0.9 kJ mol(-1). Thermodynamic parameters (deltaH(p) degrees = -16.8 +/- 1.6 kJ mol(-1), deltaS(p) degrees = -27.4 +/- 4.6 J mol(-1) K(-1)) for the polymerization of (-)-menthide were also determined by measuring the equilibrium monomer concentration at different temperatures ranging from 40 to 100 degrees C. The equilibrium monomer concentrations at 25 and 100 degrees C were calculated to be 0.031 +/- 0.018 and 0.120 +/- 0.063 M, respectively.
Joint image classification and compression using hierarchical table-lookup vector quantization (2002)

Classification and compression play important roles today in communicating digital information and their combination is useful in many applications. The aim is to produce image classification without any further signal processing on the compressed image. This paper presents techniques for the design of block based joint classifier and quantizer classifiers/encoders implemented by table lookups. In the table lookup classifiers/encoders, input vectors to the encoders are used directly as addresses in code tables to choose the codewords with the appropriate classification information. In order to preserve manageable table sizes for large dimension VQs, hierarchical structures that quantize the vector successively in stages are used. Since both the classifier/encoder and decoder are implemented by table lookups, there are no arithmetic computations required in the final system implementation. They are unique in that both the classifier/encoder and the decoder are implemented with only table lookups and are amenable to efficient software and hardware solutions.
Mac OS X Snow Leopard (2009)

The latest update of David Pogue's immensely popular Mac manual offers a wealth of detail on Apple's latest Mac OS X operating system. Known as i?½Snow Leopardi?½', this version of OS X is faster and more reliable than its predecessors, and no one is a faster or more reliable Snow Leopard resource than bestselling author and i?½New York Timesi?½ tech columnist David Pogue. His meticulous coverage includes crystal-clear, jargon-free introductions to the Dock, the Mac OS X folder structure, and the Mail application. There are also mini-manuals on iLife applications such as iMovie, iDVD, and iPhoto, and a tutorial for Safari, Mac's web browser. i?½Mac OS X Snow Leopard: The Missing Manuali?½ is the authoritative book for Mac users of all technical levels and experience. There's something new on practically every page of this edition, and David Pogue brings his celebrated wit and expertise to every one of them. No wonder it's one of the most popular computer book of all time.
A Study on Physical Self Concept Between Boys' and Girls' High School Students (1990)

The purpose of this study was to investigate physical self concept between high school boys and girls and to find various factors affecting them. For the Survey, 331 respondents for boys and 347 for girls were randomly selected from one coeducational high school in Seoul, from May 16 to May 19, 1990. The instrument used in this questionaire survey method was a part of Won Shik Jung's Physical Self Concept Scale for measuring Self Concept, it's reliability was' Cronbach a = 0.718. For the analysis. descriptive statistics were used by calculating frequencies, percentages and mean scores. , t-test, and analysis of variance were employed to test the differences and statistical significance. The relationship between physical self concept and area variables was analysed by use of Pearson's correlation coiefficients. For the examine of various factors affecting physical self concept, multiple stepwise regression method was employed. The results of this study are summarized as follows: 1. There was no significant difference in physical self concept between male and female students. 2. The scores of physical self concept among the students were negatively correlated with their academic year, even though statistical signification was not found. 3. Physical self concept was classified into two areas; health area and appearance area. There was no significant difference in health area between boys and girls. But, the difference of health area was significant in accordance with the academic years. That, the scores of the health area are dropped as academic year going up. 4. Significant relationship was revealed among health area, appearance area, and physical self concept. The correlation between health area and physical self concept was the highest relationship (r = 0.71) The main factors affecting the physical self concept were (1) father's educational background (2) year (3) number of brother (4) religion (5) father's age. 5. As academic year going up, the rate of counseling with parents are dropped. In conclusion, the result of the study indicate that, a person managed the school health and parents can help students to promote their physical, mental, and emotional health by means of health education and counseling.
Intracavity pumping for increased output power froma distributed feedback erbium fibre laser (1996)

The use of an Yb3+-fibre host laser when intracavity pumping a distributed feedback erbium fibre laser is demonstrated. Compared with direct 980 nm pumping of the same DFB laser, a three-fold increase in output power is obtained.
Effect of ascorbic acid on response to methacholine challenge in asthmatic subjects. (1983)

We studied the effect of ascorbic acid in 14 mild asthmatic subjects. The effect of ascorbic acid (1.0 g orally) was assessed by the changes in concentration of methacholine required to decrease the specific airway conductance by 40% (pD40). Ascorbic acid increased pD40 from control values of 9.38 +/- 1.97 mg/ml (mean +/- SEM) to 12.59 mg/ml +/- 2.52 (p less than 0.05). Administration of 50 mg of indomethacin, orally, reversed the effect of ascorbic acid. Indomethacin alone had no effect on the mean pD40. The results suggest that ascorbic acid exerts its effect via alteration of arachidonic acid metabolism.
Semi-blind equalisation for multiple-input multiple-output MC-CDMA (2001)

This paper presents a semi-blind equalisation scheme for a multi-carrier code division multiple access system (MC-CDMA). The combination of a MC technique (OFDM) and spread-spectrum technique (CDMA) gives rise to an access technique which is robust to channel impairments, relatively low complexity and high flexibility in bandwidth assignment. The technique proposed in this paper uses a blind channel estimation technique assuming previous knowledge of the frequency spreading code of desired user's signal. It makes use of orthogonal transmit diversity and multiple antennas at the receiver, providing diversity gain and immunity to multipath fading and co-channel interference.
Molecular Pathways Regulating Pro-migratory Effects of Hedgehog Signaling (2006)

The Hedgehog proteins play a crucial role in metazoan embryo development. Constitutive activation of the pathway is associated with multiple types of cancer. Recent experimental data suggest involvement of Hedgehog signaling in vascular remodeling, germ cell migration, and axon guidance. The molecular mechanisms underlying these effects remain elusive. Here we show that yolk sac-derived endothelial cells and embryonic fibroblasts can directly respond to the Hedgehog signal by increased migration in an in vitro scratch (wound) assay. We also identify Hedgehog transcriptional target genes in these cells, many of which participate in cell migration, axon guidance, and angiogenesis processes. Inhibition of one such molecular pathway, neuropilin-flavomonooxygenase, blocks Hedgehog-induced cell migration. These findings suggest that Hedgehog signaling directly affects embryonic endothelial and fibroblast cell migration via molecules and pathways known to regulate cell migration in response to a variety of environmental cues.