gebhart/patrepeval huggingface dataset:
Weight Gain During Treatment of Bipolar I Patients With Olanzapine (2004)

Weight gain associated with long-term olanzapine treatment for mania was common, substantial, time-dependent, predicted by initial increases, and temporally associated with significant changes in cardiovascular and metabolic measures in bipolar I patients with prolonged illness and already-high basal BMI. An association of weight gain with favorable clinical response probably reflects longer olanzapine treatment.
A Fastening Tool Tracking System Using an IMU and a Position Sensor With Kalman Filters and a Fuzzy Expert System (2008)

This paper utilizes an intelligent system which incorporates Kalman filters (KFs) and a fuzzy expert system to track the tip of a fastening tool and to identify the fastened bolt. This system employs one inertial measurement unit and one position sensor to determine the orientation and the center of mass location of the tool. KFs are used to estimate the orientation of the tool and the center of mass location of the tool. Although a KF is used for the orientation estimation, orientation error increases over time due to the integration of angular velocity error. Therefore, a methodology to correct the orientation error is required when the system is used for an extended period of time. This paper proposes a method to correct the tilt angle and orientation errors using a fuzzy expert system. When a tool fastens a bolt, the system identifies the fastened bolt using a fuzzy expert system. Through this bolt identification step, the 3-D orientation error of the tool is corrected by using the location and orientation of the fastened bolt and the position sensor outputs. Using the orientation correction method will, in turn, result in improved reliability in determining the tool tip location. The fastening tool tracking system was experimentally tested in a lab environment, and the results indicate that such a system can successfully identify the fastened bolts.
‘Resistance Through Rituals’, ‘Policing the Crisis’ and the present conjuncture (2014)

‘Resistance Through Rituals’, ‘Policing the Crisis’ and the present conjuncture This article deals with three questions. What did resistance mean in the 1970s and what does it mean today? Have the rituals of resistance changed over time? What is the status today of moral panic theory? These questions directly refer to ‘Resistance Through Rituals’ (1976) and ‘Policing the Crisis’ (1978). For that reason, one of the authors answers these key questions in a contemporary framework of hegemony, security and neoliberal politics, and points to the continuing relevance of the political and critical tradition of British cultural studies.
POLAR ORBITAL OCEAN CIRCULATION (2009)

1. PHEMONENOLOGICAL ASPECT : OCEAN FRONT IN RELATION TO OVERTURN OF OCEAN CIRCULATION IN THE NORTH ATLANTIC
ChemInform Abstract: Long Wavelength Ce<sup>3+</sup> Emission in Y—Si—O—N Materials. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Joint petrophysical inversion of multifrequency conductivity and permittivity logs derived from subsurface galvanic, induction, propagation, and dielectric dispersion measurements (2018)

Borehole-based subsurface electromagnetic (EM) measurements, namely, galvanic resistivity (laterolog), induction, propagation, and dielectric dispersion logs, are commonly used for water-saturation estimation in hydrocarbon-bearing formations. EM logs exhibit frequency dependence due to the interfacial polarization (IP) effects arising from clay-grain surfaces, conductive minerals, and charge blockage in pore throats. IP effects in shale formations adversely affect the log-derived water-saturation estimates, especially when there is low porosity, high salinity, the presence of pyrite disseminations, and high clay concentration. Conventional EM log-interpretation methods estimate water saturation in shale formations by separately interpreting the galvanic, induction, propagation, and dielectric dispersion logs using various empirical models or mixing laws. This approach leads to significant variations and uncertainties in petrophysical estimations. We have developed an inversion-based joint petrophysical interpretation of multifrequency effective electrical conductivity and dielectric permittivity logs derived from various combinations of the four aforementioned downhole EM logs acquired in clay- and pyrite-rich shale formations. The proposed joint-interpretation method uses a single mechanistic model that accounts for the IP effect arising from clay and conductive mineral grains, thereby generating physically consistent water-saturation estimates in shales. The proposed inversion-based interpretation also generates estimates of formation brine conductivity, surface conductance of clay, and average radius of clay and conductive mineral grains. The proposed method is applied to one field case and three synthetic geologic formations, with varying clay type, conductive mineral properties, and water saturation. Further, the sensitivity of inversion-derived estimates to the presence of various types of noise in the EM logs is investigated. The joint petrophysical inversion algorithm is applied to field broadband dispersion EM data acquired in an organic-rich shale formation. Water saturation, brine conductivity, surface conductance of clay, and radius of clay were consistently estimated in the shale formation using various combinations of available EM logs.
Simultaneous Shotgun Sequencing of Multiple cDN A Clones (1997)

This study describes an efficient method for the rapid sequencing of DNA fragments in the size range 1-5 kb. Individual fragments, here cDNA inserts, are purified by restriction enzyme digestion and gel purification, pooled and concatenated by ligation. The concatamers are sheared and cloned randomly into M13, followed by random sequencing. The sequences of the individual cDNA inserts are obtained at the assembly stage using restriction enzyme sites as "tags' for the ends of each fragment. In this study the sequencing of two libraries containing 7 and 16 cDNA inserts with an average length of 2.5 kb is described. The results show that of the shotgun sequencing of large fragments, and that the method compares favorably to alternative strategies, such as primer walking.
Trellis decoding of linear block codes (2002)

The purpose of this paper is the investigation of trellis decoding of linear block codes. The intersymbol relationship of convolutional codes makes the Viterbi algorithm ideally suited as a decoding strategy. By representing linear block codes in trellis form, the Viterbi algorithm can also be used to decode linear block codes. A distinct advantage of the Viterbi algorithm above traditional block decoders, is the existence of efficient soft decision algorithms employing channel measurement information. This paper will investigate a method of constructing trellises for block codes as well as the Viterbi decoding of block codes using these trellises. The proposed block trellis decoding technique will be supported with simulation results, comparing its performance with traditional methods such as syndrome decoding.
Octreotide-Mediated Tumor-Targeted Drug Delivery via a Cleavable Doxorubicin–Peptide Conjugate (2015)

Although recent methods for targeted drug delivery have addressed many of the existing problems of cancer therapy associated with undesirable side effects, significant challenges remain that have to be met before they find significant clinical relevance. One such area is the delicate chemical bond that is applied to connect a cytotoxic drug with targeting moieties like antibodies or peptides. Here we describe a novel platform that can be utilized for the preparation of drug-carrier conjugates in a site-specific manner, which provides excellent versatility and enables triggered release inside cancer cells. Its key feature is a cleavable doxorubicin-octreotide bioconjugate that targets overexpressed somatostatin receptors on tumor cells, where the coupling between the two components was achieved through the first cleavable disulfide-intercalating linker. The tumor targeting ability and suppression of adrenocorticotropic hormone secretion in AtT-20 cells by both octreotide and the doxorubicin hybrid were determined via a specific radioimmunoassay. Both substances reduced the hormone secretion to a similar extent, which demonstrated that the tumor homing peptide is able to interact with the relevant cell surface receptors after the attachment of the drug. Effective drug release was quickly accomplished in the presence of the physiological reducing agent glutathione. We also demonstrate the relevance of this scaffold in biological context in cytotoxicity assays with pituitary, pancreatic, and breast cancer cell lines.
A pilot study on gender differences in conversational speech on lexical in richness measures (2001)

Recent research on gender differences in language has mostly addressed cognitive differences. These differences have been observed on different cognitive verbal and non–verbal tasks and conclusions on the variability in language production and comprehension have been drawn from their results. In this paper, a different approach is presented. This pilot study examines lexical richness measures in conversational speech across a total of thirty subjects. All subjects were recorded and transcribed in a conversational setting. Their transcribed speech was analysed using a set of lexical richness measures based on word–frequencies. On the basis of these measurements, statistical discriminant analysis is able to classify the two groups with 90 per cent (74 per cent with leave–one–out cross–validation) correct prediction rate at a statistically significant level (P = 0. 03). The results are discussed in detail, including correlation and principal components analysis. The paper concludes that there are interesting differences across the two groups on the measures studied and further research in this area is needed.
A new technique for calibrating piezoresistive stress sensor chips (2008)

Piezoresistive stress sensors are considered to be a powerful tool for experimental stress analysis of electronic packages. The stress sensors are fabricated into the surface of the chip and thus, they are an integral part of the chip to be studied. The chip stresses result in resistance changes in the sensors due to the piezoresistance effect that can be measured. Therefore, the sensors are capable of providing chip surface stress states even in encapsulated packages. To use the stress sensor test chip in estimating the stresses, there are several constants in the equations that need to be determined prior to the stress measurements. The accuracy of the stress measurements depends on the accuracy of these constants. The determination of these constants is termed the calibration of the piezoresistive sensors.One of the well-established calibration procedures is a four- point bending technique. This technique is widely used because a uniform, uni-axial stress state can be easily obtained between two inner supports of the fixture on which the sample rests. Several researchers in the past have developed different four point bend testing fixtures and techniques. Most of the techniques developed involved the use of metal probes to probe the sensors and measure the resistance of the sensors. The probe forces are measured in the current study and it is observed that these forces can be between 5-10 grams in order to obtain a measurement. The probe forces induce uncertainty in the uni-axial stress in the sample that can be greater than 5% depending on the force applied to the sample. The current study establishes a new calibration method that eliminates the use of probes in the measurements. The technique developed completely eliminates the uncertainty in the constants that arise as a result of probing. The reduction of uncertainties in the calibration constants increases the accuracy of the stress measurements.
Drying Eastern Hardwood Lumber, No. 528 (1978)

This archival publication may not reflect current scientific knowledge or recommendations. Current information available from the University of Minnesota Extension: https://www.extension.umn.edu.
Real-time fault detection and situational awareness for rovers: report on the mars technology program task (2004)

In this paper we describe the results of a project funded by the Mars technology program at NASA, aimed at developing algorithms to meet this requirement. We describe a number of particle filtering-based algorithms for state estimation which we have demonstrated successfully on diagnosis problems including the K-9 rover at NASA Ames Research Center and the Hyperion rover at CMU. Due to the close interaction between a rover and its environment, traditional discrete approaches to diagnosis are impractical for this domain. Therefore we model rover subsystems as hybrid discrete/continuous systems. There are three major challenges to make particle filters work in this domain. The first is that fault states typically have a very low probability of occurring, so there is a risk that no samples enter fault states. The second issue is coping with the high-dimensional continuous state spaces of the hybrid system models, and the third is the severely constrained computational power available on the rover. This means that very few samples can be used if we wish to track the system state in real time. We describe a number of approaches to rover diagnosis specifically designed to address these challenges.
Cytotoxicity of novel 4,5,6,7-tetrahydrobenzo[b]thiophene derivatives towards human tumor and normal cell lines and their uses as anti-leishmanial agents (2013)

This work has been carried out to investigate some reactions of 4,5,6,7-tetrahydrobenzo[b]thiophene derivatives 1a,b to give synthesis a series of novel heterocyclic products like N-ethoxymethino derivatives (2a, 2b), N-phenylaminomethino derivatives (3a, 3b), hydrazine derivatives (5a-d), pyrazole derivatives (7a-d, 10a-d, 11a, 11b) and N-methinonitrilo derivatives (9a-d). The antitumor evaluation of the newly synthesized compounds against the three human tumor cells lines namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) showed that some of these compounds exhibit much higher inhibitory effects towards the three tumor cell lines than the positive control doxorubicin. Moreover, they were tested against normal cells namely diploid normal human fibroblast (WI-38), Normal prostate epithelial cells (PrEC) and normal human mucosal epithelial cells (NCM 460). The anti-leishmanial evaluations of the obtained compounds were also performed. Compounds 7d and 10b were the most active towards tumor cell lines while compounds 3a, 3b, 9b and 9d were the most active compounds as anti-leishmanial. Docking of these most active compounds is demonstrated.
Differentiation and migration of neural crest stem cells are stimulated by pancreatic islets (2009)

Neural crest stem cells (NCSCs) migrate during embryonic development towards the endoderm-derived pancreas and the interaction between NCSCs and beta-cell progenitors is crucial for their mutual differentiation. In diabetes, loss of beta-cells or impaired beta-cell function is accompanied by nerve degeneration, which contributes to the progression of the disease. Here we show that adult pancreatic islets markedly promote differentiation of NCSCs towards neuronal phenotype in vitro and in vivo after transplantation and increase their migration towards islets. These findings indicate that pancreatic islets can be used to promote differentiation of NCSCs towards neuronal phenotype and that this in-vitro system may help elucidate interactions between NCSCs and healthy or diseased beta-cells.
Packet routing function on the PDC mobile packet data communication network (2002)

The basic architecture of the PDC mobile packet data communication system (PDC-P), which is based on the PDC (Personal Digital Cellular telecommunication system), has been already proposed. The PDC is the standard digital mobile communication system in Japan. The PDC-P enables PDC users to send and receive packet data in the connectionless environment of multimedia mobile communications. This paper presents routing functions for a data packet on the PDC-P. First, this paper proposes a method for deriving from the destination packet address information about the location of the relevant mobile station using a conversion table. This table describes the relationship between packet addresses and mobile subscriber international ISDN numbers. Secondly, the handover and the caching function at the gateway are described. Lastly, realizations of several services on the PDC-P using the IN (intelligent network) concept are described.
STUDIES ON THE NUTRITIONAL VALUE OF DEFATTED FISH FLOUR (1960)

In studies on the nutritional value of defatted fish flour, groups of male weanling rats were given otherwise adequate diets containing 7%, 10%, or 15% protein supplied by fish flour or casein. After 4 weeks, protein efficiency ratio (P.E.R.) values found for 7% and 10% fish flour were significantly higher than those for comparable levels of casein, but similar values were found for both proteins at the 15% level. The kidneys of the animals given diets containing 15% protein were significantly heavier than those of the animals fed the other diets, but level or source of dietary protein had no significant effects on liver and adrenal weights, or liver lipid levels.In further studies, fish flour was added to whole wheat flour or to white bread prior to baking, and the resulting mixtures were fed to growing male rats at the 10% protein level. Addition of 2, 4, or 6 lb of fish flour per 100 lb of whole wheat flour increased the P.E.R., in a stepwise manner, from 1.49 to 2.80 but had no effect on organ weights or liver lipid levels. Addition of 10% fish flour to white bread made with or without 4.2% milk solids increased the P.E.R. values by 82%, and 198% respectively, and significantly decreased liver lipid levels. The P.E.R. values for bread and flour diets were found to be a direct function of the lysine content of the protein.It was concluded that defatted fish flour is an excellent source of high quality protein, and should be of particular value in supplementing diets deficient in lysine.
Syntheses relevant to vitamin B12 biosynthesis: synthesis of sirohydrochlorin and of its octamethyl ester (1985)

Sirohydrochlorin is an isobacterichlorin isolated (a) as the metal-free prosthetic group of sulphite reductase and (b) as the aromatised form of the di-C-methylated intermediate on the biosynthetic pathway to vitamin B12; the synthesis is described of the natural enantiomer of sirohydrochlorin and also of its octamethyl ester using a mild photochemical route.
A Lithography‐Free and Field‐Programmable Photonic Metacanvas (2017)

The unique correspondence between mathematical operators and photonic elements in wave optics enables quantitative analysis of light manipulation with individual optical devices. Phase-transition materials are able to provide real-time reconfigurability of these devices, which would create new optical functionalities via (re)compilation of photonic operators, as those achieved in other fields such as field-programmable gate arrays (FPGA). Here, by exploiting the hysteretic phase transition of vanadium dioxide, an all-solid, rewritable metacanvas on which nearly arbitrary photonic devices can be rapidly and repeatedly written and erased is presented. The writing is performed with a low-power laser and the entire process stays below 90 °C. Using the metacanvas, dynamic manipulation of optical waves is demonstrated for light propagation, polarization, and reconstruction. The metacanvas supports physical (re)compilation of photonic operators akin to that of FPGA, opening up possibilities where photonic elements can be field programmed to deliver complex, system-level functionalities.
Valproic acid inhibits proliferation and changes expression of CD44 and CD56 of malignant glioma cells in vitro. (1998)

Recently we were able to show that valproic acid (VPA) induces growth-arrest and differentiation of human neuroblastoma cells. Hence we investigated in vitro the antitumoral effects of VPA on malignant gliomas by determining cell proliferation and expression of CD56 and CD44 of human T98G, A172, 85HG66, 86HG39 and rat C6 cell lines. VPA at concentrations ranging from 0.1 to 1 mM strongly inhibited proliferation of A172, 86HG39, 85HG66 and C6 cells in a dose-dependent manner, whereas T98G cell growth remained unchanged. All human glioma cells were highly positive for CD44, whereas CD56 was differently expressed. After 7 days of incubation with 1mM VPA CD56 expression was markedly increased in T98G, A172 and 85HG66 cells, whereas CD44 expression was decreased in all human cell lines. These data suggest that VPA has antitumoral effects on malignant glioma cells. Therefore we consider VPA as a potent therapeutic agent for treatment of these tumors.
Stages on the way to breast cancer (2002)

Pathways to breast cancer have been difficult to define using morphology alone. Although epithelial hyperplasia of usual type (HUT) is associated with moderately elevated breast cancer risk, molecular evidence placing it in a cancer precursor pathway is not clear-cut. Recent evidence suggests that small numbers of cytokeratin 5/6 positive cells are precursors of separate lineages which acquire either cytokeratin 8/18/19 or smooth muscle actin (SMA) and cytokeratin 14 on separate pathways to fully differentiated epithelial and myoepithelial phenotypes (and may ultimately lose cytokeratin 5/6 expression). Immunohistochemistry shows that most HUT have a mixed precursor phenotype resembling normal breast with co-expression of cytokeratin 5/6, 8/18/19 and SMA, in contrast to atypical ductal hyperplasia (ADH) and ductal carcinoma in situ which typically have a 'mature' luminal phenotype positive for cytokeratin 8/18/19 but lacking cytokeratin 5/6 expression. While this supports the idea of a biological discontinuity between HUT and ADH/DCIS, caution is called for in the diagnostic use of these reagents until greater experience has been accumulated, and other published data do show features of HUT intermediate between normal breast lobules and ADH.
Annealing behavior of magnetic anisotropy in CoNbZr films (1988)

The effect of magnetic and nonmagnetic annealing on the magnetic anisotropy in CoNbZr films, formed by a DC opposing-targets sputtering method, was investigated. It was revealed that the origin of the magnetic anisotropy is the directional ordering of the magnetic atoms. The anisotropy fields and the direction of the easy axis obtained when the films are annealed in zero magnetic field are almost the same as those for the magnetic field parallel to the easy axis of the as-deposited films. When the films are annealed in a magnetic field perpendicular to the easy axis, the anisotropy field induced in parallel with the magnetic field, H/sub k/(t), is well represented by the following formula: ln (1-H/sub k/(t)/H/sub k/( infinity ) varies as - square root Tt, where H/sub k/( infinity ) is the thermal equilibrium value of the anisotropy field and D is the diffusion constant. The activation energy of the as-deposited film is 0.86 eV. Annealing the film increases the activation energy which is 2.1 eV when the film is annealed at a temperature of 450 degrees C for 2 h.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>