gebhart/patrepeval huggingface dataset:
Parallel intra coding for HEVC on CPU plus GPU platform (2015)

In High Efficiency Video Coding (HEVC), the intra coding performance is significantly improved due to the recursive splitting structure and up to 35 intra prediction modes. However, the computational complexity of intra coding increases largely as well. In this paper, a fast intra coding scheme is proposed based on CPU and GPU cooperation. Firstly, the intra prediction of variable blocks is performed in parallel on multi-cores GPU. Secondly, the intra prediction mode with minimum Sum of Absolute Difference (SAD) cost is selected and transmitted to the host CPU. Instead of exhaustively searching all the intra modes in Rough Mode Decision (RMD) process, the mode returned by the GPU is directly selected. Lastly, the texture gradient of each coding unit (CU) is assessed during parallel intra prediction, then used by the CPU for fast CU size decision. Experiment results show that the proposed parallel intra coding method achieves up to 62% complexity reduction with acceptable coding performance loss.
Classifying latent user attributes in twitter (2010)

Social media outlets such as Twitter have become an important forum for peer interaction. Thus the ability to classify latent user attributes, including gender, age, regional origin, and political orientation solely from Twitter user language or similar highly informal content has important applications in advertising, personalization, and recommendation. This paper includes a novel investigation of stacked-SVM-based classification algorithms over a rich set of original features, applied to classifying these four user attributes. It also includes extensive analysis of features and approaches that are effective and not effective in classifying user attributes in Twitter-style informal written genres as distinct from the other primarily spoken genres previously studied in the user-property classification literature. Our models, singly and in ensemble, significantly outperform baseline models in all cases. A detailed analysis of model components and features provides an often entertaining insight into distinctive language-usage variation across gender, age, regional origin and political orientation in modern informal communication.
Square deployable frames for space applications. Part 2: Realization (2007)

In a sister paper, the authors have proved mathematically that the three-dimensional 4 R overconstrained Bennett linkage has an alternative form allowing it to be folded up completely. In this paper, the ways of building such structures are shown. For design purposes, a set of design parameters is introduced that could be used for rapid prototyping because they are closely linked with the final expanded configuration. The relationships between the design and geometrical parameters, commonly used to describe the Bennett linkages by kinematicians, have been derived. Moreover, the concept of a single compact folding Bennett linkage has been extended to a grid in which the Bennett linkages are nested within each other. The new assembly retains all the common features of the single linkage. A series of physical models were made, which successfully demonstrate the concept.
Telnet Binary Transmission (1983)

This RFC specifies a standard for the ARPA Internet community.
Architectures for efficient power sharing in active multiple-feed-per-beam satellite antennas (2016)

Architectures for active multiple-feed-per-beam satellite antennas with power amplifiers shared between adjacent beams are presented. Different concepts for sharing solid state power amplifiers (SSPAs) to reduce required power margins for a K-band scenario are proposed and compared. In scenarios with data traffic and rain attenuation unequally distributed across the beams the overall efficiency can be increased.
Microfluidic platforms for RNA interference screening of virus–host interactions (2013)

RNA interference (RNAi) is a powerful tool for functional genomics with the capacity to comprehensively analyze host-pathogen interactions. High-throughput RNAi screening is used to systematically perturb cellular pathways and discover therapeutic targets, but the method can be tedious and requires extensive capital equipment and expensive reagents. To aid in the development of an inexpensive miniaturized RNAi screening platform, we have developed a two part microfluidic system for patterning and screening gene targets on-chip to examine cellular pathways involved in virus entry and infection. First, a multilayer polydimethylsiloxane (PDMS)-based spotting device was used to array siRNA molecules into 96 microwells targeting markers of endocytosis, along with siRNA controls. By using a PDMS-based spotting device, we remove the need for a microarray printer necessary to perform previously described small scale (e.g. cellular microarrays) and microchip-based RNAi screening, while still minimizing reagent usage tenfold compared to conventional screening. Second, the siRNA spotted array was transferred to a reversibly sealed PDMS-based screening platform containing microchannels designed to enable efficient cell loading and transfection of mammalian cells while preventing cross-contamination between experimental conditions. Validation of the screening platform was examined using Vesicular stomatitis virus and emerging pathogen Rift Valley fever virus, which demonstrated virus entry pathways of clathrin-mediated endocytosis and caveolae-mediated endocytosis, respectively. The techniques here are adaptable to other well-characterized infection pathways with a potential for large scale screening in high containment biosafety laboratories.
Research on Super Capacitor Voltage Balancing of Electric Vehicle Charging Stations (2015)

In this paper, we design a dynamic voltage balancing circuit between the super capacitor module which is suitable for electric vehicle charging station. The voltage balancing circuit using the energy transfer for the purpose of the voltage balance. Through the 'peak load shifting' way, achieve all the super capacitor unit voltage relative equilibrium. This equalization circuit compared with the existing voltage balancing strategy, each super capacitor unit can implement automatic equalizing, simplify the circuit. Power conversion device in the circuit realize zero current switching, reduce the circuit loss. At the same time through the voltage balancing circuit calculation analysis, get the main factors influencing the performance of circuit, in order to carry out the parameter design for the circuit. Simulation and experimental results show that the equalization circuit has good balancing effect.
cDNA Cloning, Sequence Analysis, and Induction by Aryl Hydrocarbons of a Murine Cytochrome P450 Gene, <i>Cyp1b1</i> (1994)

C3H mouse embryo fibroblast cells, designated 10T1/2, can be transformed by physical and chemical agents including polycyclic aromatic hydrocarbons. In a previous report (Shen et al., Proc. Natl. Acad. Sci. USA 90, 11483-11487, 1993), we identified a cytochrome P450 gene induced by polycyclic aromatic hydrocarbons (PAHs) that is different from 1A1 or 1A2, and which we tentatively named P450CMEF. Here, we report the entire cDNA sequence of P450CMEF (5,128 bp) and the amino acid sequence deduced from it (543 residues). A comparison of the latter sequence with known cytochrome P450s indicates that P450CMEF is in a new subfamily of family 1 of the P450 superfamily. Accordingly, the Committee on Standardized Cytochrome P450 Nomenclature designated the gene Cyp1b1. Exposure to various aryl hydrocarbons (2.5 hr) induced Cyp1b1 mRNA in 10T1/2 cells to different degrees: 2,3,7,8-tetrachlorodibenzo-p-dioxin, 7,12-dimethylbenz[a]anthracene, benz[a]anthracene, benzo[a]pyrene, and beta-naphthoflavone were strong inducers; alpha-naphthoflavone and 3-methylcholanthrene, were moderate inducers; and benzo[e]pyrene was a weak inducer.
Merging strategic and tactical planning in dynamic and uncertain environments (1994)

This paper presents a new approach to planning in dynamic and uncertain environments. Planning is viewed as a process in which an agent's long term goals are transformed into short term tasks and objectives, given the agent's strategy and the context of planning. The developed model allows for a dynamic balance between long term strategic planning and short term tactical planning. The notion of a strategy hierarchy is introduced to explicitly represent the process of strategy formulation and refinement. A combination of rules and plan scripts is used. Rules are used for representing domain knowledge and reasoning about strategic choices. Plan scripts are used for representing specific tasks and objectives. The uncertainty calculi of RUM/PRIMO are used for supporting reasoning under uncertainty. In the proposed model, it is also possible to achieve a seamless integration of case-based reasoning into the planning process. These ideas have been implemented in a system called MARS, which plans in the financial domain of mergers and acquisitions.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
ENHANCED OIL SPILL SURVEILLANCE, DETECTION AND MONITORING THROUGH THE APPLIED TECHNOLOGY OF UNMANNED AIR SYSTEMS (2008)

ABSTRACT Many leading edge technologies that are conceptualized, developed, tested, refined and applied as military defense technologies evolve into useful applied technologies in other public and private sectors. Unmanned Air Systems (UAS) and the rapidly evolving Small Unmanned Air Vehicle (SUAS) are finding operational applications in scientific research, wildlife, law enforcement, security, natural disaster, and environmental surveillance, detection and monitoring. This paper will review the use of UAS in operational oil spill surveillance, monitoring and assessment. UAS show particular potential for shoreline, coastal and inland surveillance and monitoring of remote areas with limited accessibility. Numerous international oil companies have sponsored UAV demonstrations focused on facility and pipeline inspection, surveillance and monitoring. Governmental agencies, including the U.S. Coast Guard and National Oceanic and Atmospheric Agency, have incorporated UAS into oil spill response exercises and test applications. Currently, many areas of high risk to pollution and high environmental sensitivity are monitored daily by costly manned aircraft surveillance; UAS can replace or augment these manned air vehicles, providing a cost effective alternative that also reduces human risks. UAS technology is continually evolving to achieve broader application:On-water launch and in-water recovery;Payload Integration - video, still daylight and nighttime IR imaging, image processing, and hazardous material air plume sensing and mapping;Command, Control and Communications (C-3) - real-time data link to the Incident Command Post;Platform Improvements - greater reliability, minimized size and weight, portability, longer operational flight time and extended range, and improved power sources;GPS positioning - pre-programmed flight patterns and break-away vectoring; andSimulation & Training - train effectively, maintain proficiency, and evolve tactics, techniques and procedures.
Functional screening identifies <scp>MCT4</scp> as a key regulator of breast cancer cell metabolism and survival (2015)

Metabolic reprogramming in cancer enhances macromolecule biosynthesis and supports cell survival. Oncogenic drivers affect metabolism by altering distinct metabolic processes and render cancer cells sensitive to perturbations of the metabolic network. This study aimed to identify selective metabolic dependencies in breast cancer by investigating 17 breast cancer cells lines representative of the genetic diversity of the disease. Using a functional screen, we demonstrate here that monocarboxylate transporter 4 (MCT4) is an important regulator of breast cancer cell survival. MCT4 supports pH maintenance, lactate secretion and non-oxidative glucose metabolism in breast cancer cells. Moreover, MCT4 depletion caused an increased dependence of cancer cells on mitochondrial respiration and glutamine metabolism. MCT4 depletion reduced the ability of breast cancer cells to grow in a three-dimensional (3D) matrix or as multilayered spheroids. Moreover, MCT4 expression is regulated by the PI3K-Akt signalling pathway and highly expressed in HER2-positive breast cancers. These results suggest that MCT4 is a potential therapeutic target in defined breast cancer subtypes and reveal novel avenues for combination treatment.
Simulation of a player-clarinet system (1986)

A time-domain simulation model has been developed for investigating the player-clarinet system. The three components which constitute the simulation model consist of the “subreed” system, reed, and clarinet. The “subreed” system (lungs, bronchi, trachea, and vocal tract) is represented in terms of an analogous circuit model to obtain the “subreed” pressure. The reed is represented as a damped, driven, nonuniform bar. The clarinet is represented in terms of its input impedance impulse response. A convolution of the impulse response with the volume flow through the reed aperture determines the mouthpiece pressure. Use of the model is valid for both small- and large-amplitude oscillations. Many of the nonlinearities associated with the clarinet are incorporated in the model in a rather natural way. Several vocal tract configurations are investigated to determine the influence of the vocal tract on the clarinet tone.
Anomalous Thrust Production from an RF Test Device Measured on a Low-Thrust Torsion Pendulum (2014)

This paper describes the test campaigns designed to investigate and demonstrate viability of using classical magnetoplasmadynamics to obtain a propulsive momentum transfer via the quantum vacuum virtual plasma. This paper will not address the physics of the quantum vacuum plasma thruster (QVPT), but instead will describe the recent test campaign. In addition, it contains a brief description of the supporting radio frequency (RF) field analysis, lessons learned, and potential applications of the technology to space exploration missions. During the first (Cannae) portion of the campaign, approximately 40 micronewtons of thrust were observed in an RF resonant cavity test article excited at approximately 935 megahertz and 28 watts. During the subsequent (tapered cavity) portion of the campaign, approximately 91 micronewtons of thrust were observed in an RF resonant cavity test article excited at approximately 1933 megahertz and 17 watts. Testing was performed on a low-thrust torsion pendulum that is capable of detecting force at a single-digit micronewton level. Test campaign results indicate that the RF resonant cavity thruster design, which is unique as an electric propulsion device, is producing a force that is not attributable to any classical electromagnetic phenomenon and therefore is potentially demonstrating an interaction with the quantum vacuum virtual plasma.
Latent transforming growth factor β1 activation in situ: quantitative and functional evidence after low‐dose γ‐irradiation <sup>1</sup> (1997)

The biological activity of transforming growth factor beta1 (TGF-beta) is controlled by its secretion as a latent complex in which it is noncovalently associated with latency-associated peptide (LAP). Activation is the extracellular process in which TGF-beta is released from LAP, and is considered to be a primary regulatory control. We recently reported rapid and persistent changes in TGF-beta immunoreactivity in conjunction with extracellular matrix remodeling in gamma-irradiated mouse mammary gland. Our hypothesis is that these specific changes in immunoreactivity are indicative of latent TGF-beta activation. In the present study, we determined the radiation dose response and tested whether a functional relationship exists between radiation-induced TGF-beta and collagen type III remodeling. After radiation exposures as low as 0.1 Gy, we detected increased TGF-beta immunoreactivity in the mammary epithelium concomitant with decreased LAP immunostaining, which are events consistent with activation. Quantitative image analysis demonstrated a significant (P=0.0005) response at 0.1 Gy without an apparent threshold and a linear dose response to 5 Gy. However, in the adipose stroma, loss of LAP demonstrated a qualitative threshold at 0.5 Gy. Loss of LAP paralleled induction of collagen III immunoreactivity in this tissue compartment. We tested whether TGF-beta mediates collagen III expression by treating animals with TGF-beta panspecific monoclonal antibody, 1D11.16, administered i.p. shortly before irradiation. Radiation-induced collagen III staining in the adipose stroma was blocked in an antibody dose-dependent manner, which persisted through 7 days postirradiation. RNase protection assay revealed that radiation-induced elevation of total gland collagen III mRNA was also blocked by neutralizing antibody treatment. These data provide functional confirmation of the hypothesis that radiation exposure leads to latent TGF-beta activation, support our interpretation of the reciprocal shift in immunoreactivity as evidence of activation, and implicate TGF-beta as a mediator of tissue response to ionizing radiation. The sensitivity of activation to low radiation doses points to a potential role for TGF-beta in orchestrating tissue response to oxidative stress. As such, radiation may be useful as a probe to delineate the consequences of latent TGF-beta activation in situ.
The Major Histocompatibility Complex of the Mouse (1979)

Like physicists striving to develop a unified field theory, immunologists are attempting to bring order to the microcosmos of defense reactions. Indications are that one of the most important constants in this microcosmos is the major histocompatibility complex (MHC) of the species. A test of any interpretation of the MHC's role in immunity is how well it explains this system's polymorphism. One of the most crucial questions an MHC hypothesis must answer is: Why are there so many alleles at this complex?
Absence of receptor interacting protein kinase 3 prevents ethanol-induced liver injury (2012)

CYP2E1-dependent RIP3 expression induces hepatocyte necroptosis during ethanol feeding. Ethanol-induced hepatocyte injury is RIP3-dependent, but independent of RIP1 kinase activity; intervention of this pathway could be targeted as a potential therapeutic strategy.
Leptin Induces Endothelin-1 in Endothelial Cells In Vitro (2002)

Leptin, a protein encoded by the obese gene, is produced by adipocytes and released into the bloodstream. In obese humans, serum leptin levels are increased and correlate with the individual's body mass index and blood pressure. Elevated serum concentrations of endothelin-1 (ET-1), a potent vasoconstrictor and mitogen, were also observed in obese subjects. The pathomechanisms underlying this ET-1 increase in obesity are poorly understood. In the present study, we investigated the influence of the ob gene product leptin on the expression of ET-1 in human umbilical vein endothelial cells (HUVECs). Binding studies using (125)I-radiolabeled leptin revealed high- and low-affinity leptin binding sites on HUVECs (Kd1=13.1+/-3.1 nmol/L and Kd2=1390+/-198 nmol/L, respectively), mediating a time- and dose-dependent increase of ET-1 mRNA expression and protein secretion after incubation of HUVECs with leptin. This leptin-induced ET-1 expression was inhibited by preincubation of HUVECs with 0.75 micromol/L antisense phosphorothioate oligonucleotides directed against the leptin receptor Ob-Rb. Furthermore, after incubation with leptin, increased nuclear staining of c-fos and c-jun, the major components of the transcription factor AP-1, and increased AP-1 DNA binding were observed. Transient transfection studies with ET-1 promoter constructs showed that leptin-induced promoter activity was abolished in the absence of AP-1 binding sites or by cotransfection with a plasmid overexpressing a mutated jun, which is able to bind c-fos but not DNA. Thus, leptin upregulates ET-1 production in HUVECs via a mechanism potentially involving jun binding members of the bZIP family.
Genetic Dissection of<i>Verticillium</i>Wilt Resistance Mediated by Tomato Ve1       (2009)

Vascular wilt diseases caused by soil-borne pathogens are among the most devastating plant diseases worldwide. The Verticillium genus includes vascular wilt pathogens with a wide host range. Although V. longisporum infects various hosts belonging to the Cruciferaceae, V. dahliae and V. albo-atrum cause vascular wilt diseases in over 200 dicotyledonous species, including economically important crops. A locus responsible for resistance against race 1 strains of V. dahliae and V. albo-atrum has been cloned from tomato (Solanum lycopersicum) only. This locus, known as Ve, comprises two closely linked inversely oriented genes, Ve1 and Ve2, that encode cell surface receptor proteins of the extracellular leucine-rich repeat receptor-like protein class of disease resistance proteins. Here, we show that Ve1, but not Ve2, provides resistance in tomato against race 1 strains of V. dahliae and V. albo-atrum and not against race 2 strains. Using virus-induced gene silencing in tomato, the signaling cascade downstream of Ve1 is shown to require both EDS1 and NDR1. In addition, NRC1, ACIF, MEK2, and SERK3/BAK1 also act as positive regulators of Ve1 in tomato. In conclusion, Ve1-mediated resistance signaling only partially overlaps with signaling mediated by Cf proteins, type members of the receptor-like protein class of resistance proteins.
Molecular cloning of a novel CC chemokine, interleukin‐11 receptor α‐locus chemokine (ILC), which is located on chromosome 9p13 and a potential homologue of a CC chemokine encoded by molluscum contagiosum virus (1999)

Molluscum contagiosum virus (MCV) encodes a CC chemokine MC148R which is likely to have been acquired from the host. By a homology search employing MC148R as a probe, we have identified a novel CC chemokine whose gene exists next to the IL-11 receptor alpha (IL-11Ralpha) gene in both humans and mice. Thus, this chemokine maps to chromosome 9p13 in humans where IL-11Ralpha has been assigned. We term this novel chemokine IL-11Ralpha-locus chemokine (ILC). ILC has the highest homology to MC148R among the known human CC chemokines. Furthermore, ILC is strongly and selectively expressed in the skin where infection of MCV also takes place. Thus, ILC is likely to be the original chemokine of MC148R.
A Novel Type of Vasopressin Receptor on Anterior Pituitary Corticotrophs?* (1985)

Suspensions of rat anterior pituitary cells were exposed to corticotropin-releasing factor (CRF) (5 nM) and various neurohormones (0.002-1000 nM). CRF-induced secretion of ACTH was doubled by 0.1 nM arginine vasopressin (AVP), 0.2 nM arginine vasotocin, 1 nM oxytocin, 10 nM angiotensin II, and 100 nM noradrenalin; vasoactive intestinal peptide had no effect at 0.2-200 nM. CRF potentiation by AVP was also observed at lower concentrations of CRF. Since AVP appeared to be the most potent modulator of CRF-induced ACTH secretion, potentiation was further tested with specific antidiuretic and oxytocic agonists. Potentiation was clearly related to pressor biological activity, less so to antidiuretic, and hardly at all to oxytocic activities. However, even at 200 nM, the antipressor antagonists dPTyr(Me)AVP and d(CH2)5Tyr(Me)AVP had no effect on potentiation by AVP. The lack of antagonism was partly due to the agonistic effects of the antagonists on the pituitary gland, an effect not observed within vascular tissue. The results thus suggest that anterior pituitary vasopressin receptors resemble, but are not identical to, V1 (pressor and hepatic), do not resemble the V2 (renal), and might be classified as V3 (pituitary) receptors.