Megestrol Acetate for Treatment of Cachexia Associated with Human Immunodeficiency Virus (HIV) Infection (1988)

Brief Reports15 November 1988Megestrol Acetate for Treatment of Cachexia Associated with Human Immunodeficiency Virus (HIV) InfectionJamie H. Von Roenn, MD, Robert L. Murphy, MD, Kathleen M. Weber, RN, BSN, Lisa M. Williams, RN, BSN, Sigmund A. Weitzman, MDJamie H. Von Roenn, MDSearch for more papers by this author, Robert L. Murphy, MDSearch for more papers by this author, Kathleen M. Weber, RN, BSNSearch for more papers by this author, Lisa M. Williams, RN, BSNSearch for more papers by this author, Sigmund A. Weitzman, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-10-840 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCachexia is a common problem in patients infected with human immunodeficiency virus (HIV) and predicts a poor prognosis (1, 2). The deleterious effects of malnutrition on immunity to infection are well recognized (3, 4). Therefore, evaluation of nutritional status and treatment, if indicated, in persons with HIV infection may be particularly important.Recently, megestrol acetate, a synthetic orally active progesterone widely used for the therapy of advanced breast cancer, was reported to stimulate the appetite and produce weight gain (5). On the basis of this information, we initiated megestrol acetate therapy in persons with HIV infection and severe anorexia and...References1. Chlebowski R. Significance of altered nutritional status in acquired immune deficiency syndrome (AIDS). Nutr Cancer. 1985;7:85-91. CrossrefMedlineGoogle Scholar2. O'Sullivan P, Linke R, and Dalton S. Evaluation of body weight and nutritional status among AIDS patients. J Am Diet Assoc. 1985;85:1483-4. CrossrefMedlineGoogle Scholar3. Chandra R. Nutrition, immunity, and infection: present knowledge and future directions. Lancet. 1983;1:688-91. CrossrefMedlineGoogle Scholar4. Chandra R and Scrimshaw N. Immunocompetence in nutritional assessment. Am J Clin Nutr. 1980;33:2694-7. CrossrefMedlineGoogle Scholar5. Tchekmedyian N, Tait N, Moody M, and Aisner J. High-dose megestrol acetate: a possible treatment for cachexia. JAMA. 1987;9:1195-8. CrossrefGoogle Scholar6. Yarchoan R, Klecker R, and Weinhold K. Administration of 3′azido-3′-deoxythymidine, an inhibition of HTLV-III/LAV replication, to patients with AIDS or AIDS-related complex. Lancet. 1986;1:575-80. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Jamie H. Von Roenn, MD; Robert L. Murphy, MD; Kathleen M. Weber, RN, BSN; Lisa M. Williams, RN, BSN; Sigmund A. Weitzman, MDFrom Northwestern University Medical School, Chicago, Illinois. For current author addresses, see end of text. 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Nelson, MD, PhDMegestrol Acetate and HyperpneaW. Jeffrey Fessel, MDMegestrol Acetate and Cachexia Associated with Human Immunodeficiency Virus (HIV) InfectionPriscilla A. Furth, MDMegestrol acetate: clinical experienceTreatment of AIDS Anorexia-Cachexia Syndrome and LipodystrophyTreatment of Cachexia in the Elderly 15 November 1988Volume 109, Issue 10Page: 840-841KeywordsBreast cancerHIVHIV infectionsImmunityInterleukinsMalnutritionNutritionProgesteroneWeight gain ePublished: 1 December 2008 Issue Published: 15 November 1988 PDF downloadLoading ...