gebhart/patrepeval huggingface dataset:
DataMesh-parallel storage systems for the 1990s (2002)

A description is given of DataMesh, a research project with the goal of developing software to maximize the performance of mass storage I/O, while providing high availability, ease of use, and scalability. The DataMesh hardware architecture is that of an array of disk nodes, with each disk having a dedicated 20-MIPS single-chip processor and 8-32 MBytes RAM. The nodes are linked by a fast, reliable, small-area network, and programmed to appear as a single storage server. Phase 1 of the DataMesh project will provide smart disk arrays; phase 2 will expand this to include file systems; and phase 3 will support parallel databases, data searches, and other application-specific functions. The initial target of the work is storage servers for groups of high-powered workstations, although the techniques are applicable to several different problems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Reliability of Overcoverage Parameters With Varying Morphologic Pincer Features: Comparison of EOS® and Radiography (2013)

EOS(®) radiography maintained excellent reliability in comparison to conventional radiography but both were equally vulnerable to the effects of tilt and rotation for quantification of hip parameters used in acetabular overcoverage assessment. A standardized pelvic radiograph ensuring that the pelvis is not excessively tilted or rotated should be used for assessing acetabular overcoverage parameters.
Mixed-Valence Tetra- and Hexanuclear Manganese Complexes from the Flexibility of Pyridine-Containing β-Diketone Ligands (2008)

The reactions of [Mn3O(O2CCCl3)6(H2O)3] with 1-phenyl-3-(2-pyridyl)propane-1,3-dione (HL(1)) and 1-(2-pyridly)-3-(p-tolyl)propane-1,3-dione (HL(2)) in CH2Cl2 afford the mixed-valence Mn(II)2Mn(III)2 tetranuclear complexes [Mn4O(O2CCCl3)6(L(1))2] (1) and [Mn4O(O2CCCl3)6L2(2)] (2), respectively. Similar reactions employing [Mn3O(O2CPh)6(H2O)(py)2] with HL(1) and HL(2) give the Mn(II)3Mn(III)3 hexanuclear complexes [Mn6O2(O2CPh)8(L(1))3] (3) and [Mn6O2(O2CPh)8L3(2)] (4), respectively. Complexes 1.2CH2Cl2, 2.2CH2Cl2.H2O, 3.1.5CH2Cl2.Et2O.H2O, and 4.2CH2Cl2 crystallize in the triclinic space group P1, monoclinic space group P2(1)/c, monoclinic space group P2 1/ n, and monoclinic space group P2(1)/n, respectively. Complexes 1 and 2 consist of a trapped-valence tetranuclear core of [Mn(II)2Mn(III)2(mu4-O)](8+), and complexes 3 and 4 represent a new structural type, possessing a [Mn(II)3Mn(III)3(mu4-O)2](11+) core. The magnetic data indicate that complexes 3 and 4 have a ground-state spin value of S = 7/2 with significant magnetoanisotropy as gauged by the D values of -0.51 cm (-1) and -0.46 cm (-1), respectively, and frequency-dependent out-of-phase signals in alternating current magnetic susceptibility studies indicate their superparamagnetic behavior. In contrast, complexes 1 and 2 are low-spin molecules with an S = 1 ground state. Single-molecule magnetism behavior confirmed for 3 the presence of sweep-rate and temperature-dependent hysteresis loops in single-crystal M versus H studies at temperatures down to 40 mK.
Baby Names, Visualization, and Social Data Analysis (2006)

The Name Voyager, a Web based visualization of historical trends in baby naming, has proven remarkably popular. This paper discusses the interaction techniques it uses for smooth visual exploration of thousands of time series. We also describe design decisions behind the application and lessons learned in creating an application that makes do-it-yourself data mining popular. The prime lesson, it is hypothesized, is that an information visualization tool may be fruitfully viewed not as a tool but as part of an online environment. In other words, to design a successful exploratory data analysis tool, one good strategy is to create a system that enables social data analysis
A Biosensor for ADP with Internal Substrate Amplification (1987)

Abstract An enzyme electrode was constructed from an oxygen electrode and a layer incorporating four enzyme systems for the sensitive determination of ADP and ATP. The cofactor is cycled between pyruvate kinase and hexokinase under formation of pyruvate which is detected by the coimmobilized, sequentially acting enzymes lactate dehydrogenase and lactate monooxygenase. The enzymatic recycling results in a 220-fold increased sensitivity to ADP compared to the unamplified reaction.
Multidimensional Clinical Phenotyping of an Adult Cystic Fibrosis Patient Population (2015)

This study demonstrated regional adult CF clinical phenotypes using non-parametric, continuous, ordinal and categorical data with a minimal amount of subjective data to identify clinically relevant phenotypes. These studies identified the relative stability of the phenotypes, demonstrated specific phenotypes consistent with published findings and identified others needing further study.
Facile one-pot preparation of thermally and photochemically convertible soluble precursors of copper phthalocyanine and naphthalocyanine (2011)

Soluble copper phthalocyanine (CuPc) and naphthalocyanine (CuNc) precursors which can be converted thermally and photochemically into insoluble CuPc and CuNc, respectively, have been synthesized by a one-step reaction using commercially available chemicals.
Study on restraint of circulating current in parallel inverters system with SPWM modulation by adjusting phases of triangular carrier waves (2013)

Aiming at the circulating current of parallel inverter with SPWM modulation for AC motor drive, a restraining method of circulating current is proposed based on the relationship between the circulating current and phase difference of carrier waves in this paper. The direction for phase difference of carrier waves has been detected according to the principle of minimal accommodation, and then the value of the phase difference has been computed from the relationship between the DC circulating current and phase difference of carrier waves. So the triangular carrier wave which is anterior has been accommodated laggardly according to the phase difference and the direction of triangular carrier waves, the circulating current has been restrained effectively. The results of simulation have verified the proposed method.
Increased NADPH-Oxidase Activity and Nox4 Expression During Chronic Hypertension Is Associated With Enhanced Cerebral Vasodilatation to NADPH In Vivo (2004)

Activation of NADPH-oxidase in cerebral arteries generates superoxide, which is dismutated by Cu(2+)/Zn(2+)-superoxide dismutase to H(2)O(2). H(2)O(2) then elicits vasodilatation via activation of BK(Ca) channels. Upregulation of Nox4 during chronic hypertension is associated with elevated cerebral artery NADPH-oxidase activity.
Gamma and proton radiation effects in erbium-doped fiber amplifiers: active and passive measurements (2001)

Commercially available Er-doped fibers were irradiated with 5.6 and 28 MeV protons and /sup 60/Co gamma rays, up to levels of 50 krad. White-light transmission spectra under passive conditions (no pump or signal) were measured at several radiation levels for the six types of fibers that were tested. The spectra were used to evaluate the relative radiation sensitivity of the fibers and compare gamma versus proton-induced damage for two fiber types. The amount of radiation damage for the fibers was observed to scale inversely with the Ge concentration. Samples from three of the fiber types were configured as optical amplifiers using 980-nm and 1550-nm pump and input signals. In situ measurements of the gain, noise figure, and amplified spontaneous emission (ASE) were made as a function of pump power at several levels of radiation. A computer code, based on a conventional Er-doped fiber amplifier (EDFA) model, was written to simulate performance, using input data provided by the fiber vendor and anchored to measurements made prior to radiation. A comparison between the simulations and experimental data shows that, in certain fibers where the damage is significant, the radiation-induced loss determined from amplifier measurements can be substantially less than that determined from passive transmission spectra.
Impact of short‐term high‐fat feeding on glucose and insulin metabolism in young healthy men (2009)

A high-fat, high-calorie diet is associated with obesity and type 2 diabetes. However, the relative contribution of metabolic defects to the development of hyperglycaemia and type 2 diabetes is controversial. Accumulation of excess fat in muscle and adipose tissue in insulin resistance and type 2 diabetes may be linked with defective mitochondrial oxidative phosphorylation. The aim of the current study was to investigate acute effects of short-term fat overfeeding on glucose and insulin metabolism in young men. We studied the effects of 5 days' high-fat (60% energy) overfeeding (+50%) versus a control diet on hepatic and peripheral insulin action by a hyperinsulinaemic euglycaemic clamp, muscle mitochondrial function by (31)P magnetic resonance spectroscopy, and gene expression by qrt-PCR and microarray in 26 young men. Hepatic glucose production and fasting glucose levels increased significantly in response to overfeeding. However, peripheral insulin action, muscle mitochondrial function, and general and specific oxidative phosphorylation gene expression were unaffected by high-fat feeding. Insulin secretion increased appropriately to compensate for hepatic, and not for peripheral, insulin resistance. High-fat feeding increased fasting levels of plasma adiponectin, leptin and gastric inhibitory peptide (GIP). High-fat overfeeding increases fasting glucose levels due to increased hepatic glucose production. The increased insulin secretion may compensate for hepatic insulin resistance possibly mediated by elevated GIP secretion. Increased insulin secretion precedes the development of peripheral insulin resistance, mitochondrial dysfunction and obesity in response to overfeeding, suggesting a role for insulin per se as well GIP, in the development of peripheral insulin resistance and obesity.
Electron Optics (1949)

Present-day electron microscopes do not achieve the magnifications theoretically possible because of the aberrations introduced by the axially symmetric electrical and magnetic fields used for lenses.
Blueshift of the<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mi>A</mml:mi></mml:math>-exciton peak in folded monolayer<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:mn>1</mml:mn><mml:mi>H</mml:mi></mml:mrow></mml:math>-MoS<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:msub><mml:mrow/><mml:mn>2</mml:mn></mml:msub></mml:math> (2013)

The large family of layered transition-metal dichalcogenides is widely believed to constitute a second family of two-dimensional (2D) semiconducting materials that can be used to create novel devices that complement those based on graphene. In many cases these materials have shown a transition from an indirect band gap in the bulk to a direct band gap in monolayer systems. In this work we experimentally show that folding a 1$H$ molybdenum disulfide (MoS${}_{2}$) layer results in a turbostratic stack with enhanced photoluminescence quantum yield and a significant shift to the blue by \ensuremath{\sim}90 meV. This is in contrast to the expected 2$H$-MoS${}_{2}$ band-structure characteristics, which include an indirect gap and quenched photoluminescence. We present a theoretical explanation for the origin of this behavior in terms of exciton screening.
Benzylguanine Thiol Self-Assembled Monolayers for the Immobilization of SNAP-tag Proteins on Microcontact-Printed Surface Structures (2010)

The site-selective, oriented, covalent immobilization of proteins on surfaces is an important issue in the establishment of microarrays, biosensors, biocatalysts, and cell assays. Here we describe the preparation of self-assembled monolayers consisting of benzylguanine thiols (BGT) to which SNAP-tag fusion proteins can be covalently linked. The SNAP-tag, a modified O(6)-alkylguanine-DNA alkyltransferase (AGT), reacts with the headgroup of BGT and becomes covalently bound upon the release of guanine. Bacterially produced recombinant His-tag-SNAP-tag-GFP was used to demonstrate the site-specific immobilization on BGT surface patterns created by microcontact printing (microCP). With this versatile method, any SNAP-tag protein can be coupled to a surface.
The self-splicing RNA of Tetrahymena is trapped in a less active conformation by gel purification (1990)

When the circular form of the self-splicing intervening sequence of Tetrahymena thermophila was purified by denaturing polyacrylamide gel electrophoresis by standard methods, the rate of its reaction with tetrauridylate decreased 150-fold at 30 degrees C and at least 1000-fold at 0 degrees C. The activity of the self-splicing RNA was restored by heating it to high temperature and letting it renature in the presence of Mg2+. The rate of reaction of tetrauridylate with the self-splicing RNA flanked by exons was also greatly decreased by gel purification. The difference in activation energies for the reaction of native and denatured intervening sequences suggests that a substantial conformational rearrangement of the gel-purified RNA occurs prior to reaction.
14-3-3 protein is a regulator of the mitochondrial and chloroplast ATP synthase (2001)

Mitochondrial and chloroplast ATP synthases are key enzymes in plant metabolism, providing cells with ATP, the universal energy currency. ATP synthases use a transmembrane electrochemical proton gradient to drive synthesis of ATP. The enzyme complexes function as miniature rotary engines, ensuring energy coupling with very high efficiency. Although our understanding of the structure and functioning of the synthase has made enormous progress in recent years, our understanding of regulatory mechanisms is still rather preliminary. Here we report a role for 14-3-3 proteins in the regulation of ATP synthases. These 14-3-3 proteins are highly conserved phosphoserine/phosphothreonine-binding proteins that regulate a wide range of enzymes in plants, animals, and yeast. Recently, the presence of 14-3-3 proteins in chloroplasts was illustrated, and we show here that plant mitochondria harbor 14-3-3s within the inner mitochondrial-membrane compartment. There, the 14-3-3 proteins were found to be associated with the ATP synthases, in a phosphorylation-dependent manner, through direct interaction with the F(1) beta-subunit. The activity of the ATP synthases in both organelles is drastically reduced by recombinant 14-3-3. The rapid reduction in chloroplast ATPase activity during dark adaptation was prevented by a phosphopeptide containing the 14-3-3 interaction motif, demonstrating a role for endogenous 14-3-3 in the down-regulation of the CF(o)F(1) activity. We conclude that regulation of the ATP synthases by 14-3-3 represents a mechanism for plant adaptation to environmental changes such as light/dark transitions, anoxia in roots, and fluctuations in nutrient supply.
Barankin Bounds on Parameter Estimation (1971)

The Schwarz inequality is used to derive the Barankin lower bounds on the covariance matrix of unbiased estimates of a vector parameter. The bound is applied to communications and radar problems in which the unknown parameter is embedded in a signal of known form and observed in the presence of additive white Gaussian noise. Within this context it is shown that the Barankin bound reduces to the Cramér-Rao bound when the signal-to-noise ratio (SNR) is large. However, as the SNR is reduced beyond a critical value, the Barankin bound deviates radically from the Cramér-Rao bound, exhibiting the so-called threshold effect. The bounds were applied to the linear FM waveform, and within the resulting class of bounds it was possible to select one that led to a closed-form expression for the lower bound on the variance of an unbiased range estimate. This expression clearly demonstrates the threshold behavior one must expect when using a nonlinear modulation system. Tighter bounds were easily obtained, but these had to be evaluated numerically. The sidelobe structure of the linear FM compressed pulse leads to a significant increase in the variance of the estimate. For a practical linear FM pulse of 1- <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">\mu s</tex> duration and 40-MHz bandwidth, the radar must operate at an SNR greater than 10 dB if meaningful unbiased range estimates are to be obtained.
Hurricane Maximum Intensity: Past and Present (2001)

Hurricane intensity forecasting has lagged far behind the forecasting of hurricane track. In an effort to improve the understanding of the hurricane intensity dilemma, several attempts have been made to compute an upper bound on the intensity of tropical cyclones. This paper investigates the strides made into determining the maximum intensity of hurricanes. Concentrating on the most recent attempts to understand the maximum intensity problem, the theories of Holland and Emanuel are reviewed with the objective of assessing their validity in real tropical cyclones. Each theory is then tested using both observations and the axisymmetric hurricane numerical models of Ooyama and Emanuel.
Wnt-signalling pathway in ovarian epithelial tumours: increased expression of β-catenin and GSK3β (2003)

Beta-catenin is involved in both cell-cell adhesion and in transcriptional regulation by the Wingless/Wnt signalling pathway. Alterations of components of this pathway have been suggested to play a central role in tumorigenesis. The present study investigated, by immunohistochemistry and immunoblotting, the protein expression and localisation of beta-catenin, adenomatous polyposis coli (APC), glycogen synthase kinase 3beta (GSK3beta) and lymphocyte enhancer factor-1 (Lef-1) in normal human ovaries and in epithelial ovarian tumours in vivo and in vitro. Immortalised human ovarian surface epithelium and ovarian cancer cell cells (OVCAR-3) expressed beta-catenin, APC, GSK3beta and Lef-1. Nuclear staining of beta-catenin and Lef-1 were demonstrated only in OVCAR-3 cells. There were significant increases of beta-catenin and GSK3beta, while APC was reduced in ovarian cancer compared to the normal ovary. Beta-catenin and Lef-1 were coimmunoprecipitated in ovarian tumours, but not in the normal ovary. Nuclear localisation of beta-catenin or Lef-1 could not be demonstrated in the normal ovary or in the ovarian tumours. The absence of nuclear localisation of beta-catenin could be due to an increased binding to the cadherin-alpha-catenin cell adhesion complex. In fact, we have earlier reported an increased expression of E-cadherin in ovarian adenocarcinomas. In summary, this study demonstrates an increase in the expression of components of the Wingless/Wnt pathway in malignant ovarian tumours. The increase suggests a role for this signalling pathway in cell transformation and in tumour progression. However, it remains to be demonstrated whether it is an increased participation of beta-catenin in transcriptional regulation, or in the stabilisation of cellular integrity, or both, that is the crucial event in ovarian tumorigenesis.
Photographic optical systems with nonrotational aspheric surfaces (1999)

Sections of nonrotational aspheric surfaces can be useful in a variety of optical situations. In several examples, image-forming objectives, as for photographic or electronic camera products, are described in which suitably located asymmetric pairs of refractive surfaces are devised, such that relative rotation about a displaced axis of one with respect to the other can be used to produce a focusing effect that is satisfactory for imaging purposes over reasonable fields of view and for practicable apertures and achromatic corrections. Taylor expansions about assignable reference points in any given surface of a sequence, together with suitable coordinate systems, can be employed to relate performance to shape parameters.
One-Year Intense Nutritional Counseling Results in Histological Improvement in Patients with Nonalcoholic Steatohepatitis: A Pilot Study (2005)

Among patients who successfully completed 1 yr of intense dietary intervention, nine of 15 patients with NASH displayed histologic improvement. This pilot study suggests that dietary intervention can be effective in improving histology in patients with biopsy-proven NASH.
COMPARISON ANALYSIS OF 16-BIT ADDERS (2014)

Adders are one of the most widely digital components in the digital integrated circuit design and are the necessary part of Digital Signal Processing (DSP) applications. With the advances in technology, researchers have tried and are trying to design adders which offer either high speed, low power consumption, less area or the combination of them. The addition of the two bits is very Based on the various speed-up schemes for binary addition, a comprehensive overview and a qualitative evaluation of the different existing basic adder architectures are given in this paper. In addition, their comparison is performed in the thesis for the performance analysis. We will synthesize the adders - Ripple Carry adder, Carry look- ahead Adder, Carry Save Adder in ISE XIILINX 10.1 by using HDL - Verilog and will simulate them in Modelsim 6.4a. We will Compare above mentioned adders in terms of Delay, Slices Used and Look up
The MWS 1X4: A High Performance Wavelength Switching Building Block (2002)

A novel compact high performance wavelength switch module enables arbitrary routing of 64 DWDM 100 Hz channels from one input into four output ports. 3.5 dB insertion loss, 50 GHz net pass and stop band and 5 W power consumption are obtained
Tunable Formation of Ordered Wrinkles in Metal Films with Controlled Thickness Gradients Deposited on Soft Elastic Substrates (2015)

Controlled wrinkled surface is useful for a wide range of applications, including flexible electronics, smart adhesion, wettability, stamping, sensoring, coating, and measuring. In this work, thickness-gradient-guided spontaneous formation of ordered wrinkling patterns in metal films deposited on soft elastic substrates is revealed by atomic force microscopy, theoretic analysis, and simulation. It is observed that in the thicker film region, broad cracks form, and the film surface remains flat. In the thinner film region, the cracks attenuate along the direction of the thickness decrease, and various wrinkle patterns including branched stripes, herringbones, and labyrinths can coexist. The interplay between the residual compression and the thickness gradient leading to the formation of such wrinkling patterns is discussed based on a nonlinear wrinkling model. The simulated wrinkling patterns as well as the variation trends of the wrinkle wavelength and amplitude along the gradient direction are in good agreement with the experimental observations. The report in this work could promote better understanding and fabrication of such ordered wrinkling patterns by tunable thickness gradient.
Transcriptome and methylome profiling reveals relics of genome dominance in the mesopolyploid Brassica oleracea (2014)

Differential expression of the triplicated syntelogs and cytosine methylation levels across the sub-genomes suggest residual marks of the genome dominance that led to the current genome architecture. Although cytosine methylation does not correlate with individual gene dominance, the independent methylation patterns of triplicated copies suggest epigenetic mechanisms play a role in the functional diversification of duplicate genes.