Metronidazole Lowers Serum Lipids (1983)

Brief Reports1 July 1983Metronidazole Lowers Serum LipidsJONATHAN L. DAVIS, M.D., THOMAS A. SCHULTZ, M.D., COLEMAN A. MOSLEY, M.D.JONATHAN L. DAVIS, M.D.Search for more papers by this author, THOMAS A. SCHULTZ, M.D.Search for more papers by this author, COLEMAN A. MOSLEY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-99-1-43 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMetronidazole, a synthetic nitro-imidazole derivative, is widely used in the treatment of infections due toEntamoeba histolytica, Giardia lamblia, and many obligately anaerobic bacteria (1). Although the drug is usually well tolerated, it has numerous side effects including nausea, metallic taste, urethral burning, dark urine, neutropenia, and peripheral neuropathies (2). It has also been shown to be carcinogenic in both rats and mice (3). Recently, we found a significant drop in both cholesterol and trigylceride levels in a patient during metronidazole therapy for giardiasis. This finding prompted a subsequent evaluation of the cholesterol and trigylceride responses in five other patients...References1. FINEGOLD S. Metronidazole. Ann Intern Med. 1980; 93:585-7. LinkGoogle Scholar2. ROLLO I. Miscellaneous drugs used in the treatment of protozol infections. In: GOODMAN LS, GILMAN A. The Pharmacological Basis of Therapeutics. 6th ed. New York: McMillan Co.; 1980:1075-7. Google Scholar3. RUSTIASHUBIK MP. Experimental induction of hepatomas, mammary tumors, and other tumors with metronidazole in noninbred Sas:MRC (WI)BR rats. J Natl Cancer Inst. 1979;63:863-7. CrossrefMedlineGoogle Scholar4. COLTON T. Statistics in Medicine. Boston: Little Brown and Company; 1974: 131-6. Google Scholar5. MILLERLINDMARKMCLAUGHLIN MDJ. Mode of action of metronidazole on anaerobic microorganisms. In: FINEGOLD SM, MCFADZEAN JA, ROE FJC, eds. Metronidazole. Princeton, New Jersey: Excerpta Medica; 1977:12-9. Google Scholar6. BIERMANGLOMSET EJ. Disorders of lipid metabolism. In: WILLIAMS RH, ed. Textbook of Endocrinology. Philadelphia: W.B. Saunders Co.; 1974:899-903. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JONATHAN L. DAVIS, M.D.; THOMAS A. SCHULTZ, M.D.; COLEMAN A. MOSLEY, M.D.Affiliations: Naval Hospital San Diego, California. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDietary Fiber, Soluble and Insoluble, Carbohydrates, Fructose, and LipidsUnintended positive and negative effects of drugs on lipoproteinsMetronidazoleMetronidazoleEffect of antibiotics as cholesterol-lowering agentsAn open label crossover trial of effects of metronidazol on hyperlipidaemiaSerum-cholesterol-lowering effect of metronidazole and possible mechanisms of actionStoffwechsel 1 July 1983Volume 99, Issue 1Page: 43-44KeywordsCholesterolEntamoeba histolyticaGiardia lambliaGiardiasisLipidsNauseaNeutropeniaPeripheral neuropathyTasteUrine ePublished: 1 December 2008 Issue Published: 1 July 1983 PDF downloadLoading ...