gebhart/patrepeval huggingface dataset:
Fluorescent hydrogel waveguide for on-site detection of heavy metal ions (2017)

Hydrogels have great applications in tissue engineering and drug delivery. Recently, there have been intense interests in developments and applications of nanocomposite hydrogels by incorporating nanomaterials into polymer matrix, which endows the hydrogels with new functionalities. Here, we report on the first carbon dots (CDs) doped hydrogel waveguide for selective, on-site detection of heavy metal ions in aqueous solutions. The CDs-doped hydrogel waveguide exhibits efficient light confinement in water due to the refractive index contrast. The smooth waveguide surfaces lead to low light scattering loss. Real-time spectra measurement of the CDs-doped hydrogel waveguide with a compact interrogation setup demonstrates that the novel design can be used as a portable, robust sensing platform for on-site analysis and assessment of heavy metal ions.
Case Report: Variably Compliant Transtibial Prosthetic Socket Fabricated Using Solid Freeform Fabrication (2007)

In Brief Achieving and maintaining a comfortable fit in a lower-limb prosthetic socket is an important goal to help ensure a successful rehabilitation. The purpose of this case study was to assess the performance of sockets with compliant features integrated into the socket wall to relieve in-socket pressure during transtibial amputee gait. Two sockets incorporating variably compliant areas over the fibula head and distal tibia were fabricated for a transtibial amputee. The two sockets were designed with different levels of compliance and were compared with a third more conventional socket without compliant areas. All three sockets were otherwise geometrically identical and were aligned identically to eliminate in-socket pressure differences due to alignment. The three sockets were fabricated using selective laser sintering, a form of solid freeform fabrication. The in-socket pressure measurements were acquired during normal walking. Tekscan F-Socket pressure sensors were attached to the amputee's residual limb rather than to the socket wall, which made it possible to measure pressures in the same location on the residual limb upon change of socket. A Vicon motion capture system was used to match in-socket pressures to the subject's gait cycle. The pressure measurements showed that the compliant socket peak pressures over the distal tibia and fibula head were similar for the two compliance levels and nearly 50% and 30% lower than the conventional socket pressures, respectively. This case study showed that selective laser sintering manufactured sockets with variably compliant regions holds great promise for reducing contact pressure in sensitive regions of the residual limb. Achieving and maintaining a comfortable fit in a lower-limb prosthetic socket is an important goal to help ensure a successful rehabilitation. The purpose of this case study was to assess the performance of sockets with compliant features integrated into the socket wall to relieve in-socket pressure during transtibial amputee gait. The two sockets were designed with different levels of compliance and were compared to a third more conventional socket without compliant areas. The three sockets were fabricated using selective laser sintering (SLS), a form of solid freeform fabrication. This case study showed that the SLS-manufactured sockets with the variably compliant regions were successful in reducing pressures in sensitive regions of the residual limb.
Use of Zirconium Phosphate-Sulphate as Acid Catalyst for Synthesis of Glycerol-Based Fuel Additives (2019)

In the present work, zirconium phosphates and mixed zirconium phosphate–sulphate acid catalysts have been investigated in the acetylation of glycerol in order to obtain acetins as fuel additives. The following catalysts with chemical composition, Zr3(PO4)4, Zr(SO4)2, Zr2(PO4)2SO4, Zr3(PO4)2(SO4)3 and Zr4(PO4)2(SO4)5 have been prepared and characterized by acid capacity measurements, BET, XRD, FT-IR, XPS. The surface chemical composition in terms of P/Zr and S/Zr atomic ratios was monitored in the fresh and used catalysts. Zr3(PO4)2(SO4)3 and Zr4(PO4)2(SO4)5 showed the highest acidity associated with the synergic effect of two main crystalline phases, Zr2(PO4)2SO4 and Zr(SO4)2·4H2O. The reactions of glycerol acetylation were carried out by using a mass ratio of catalyst/glycerol equal to 5 wt% and molar ratio acetic acid/glycerol equal to 3:1. The glycerol conversion versus time was investigated over all the prepared samples in order to identify the best performing catalysts. Over Zr3(PO4)2(SO4)3 and Zr4(PO4)2(SO4)5 full glycerol conversion was achieved in 1 h only. Slightly lower conversion values were registered for Zr3(PO4)4 and Zr2(PO4)2SO4, while Zr(SO4)2 was the worst catalyst. Zr4(PO4)2(SO4)5 was the most selective catalyst and was used for recycling experiments up to five cycles. Despite a modest loss of activity, a drastic decrease of selectivity to tri- and diacetin was observed already after the first cycle. This finding was attributed to the leaching of sulphate groups as detected by XPS analysis of the spent catalyst.
New aminoporphyrins bearing urea derivative substituents: synthesis, characterization, antibacterial and antifungal activity (2015)

This work studied the synthesis of 5,10,15-tris(4-aminophenyl)-20-(N,N-dialkyl/diaryl-N-phenylurea) porphyrins (P1-P4 with alkyl or aryl groups of Ph, iPr, Et and Me, respectively) and also the preparation of their manganese (III) and cobalt (II) complexes (MnP and CoP). The P1-P4 ligands were characterized by different spectroscopic techniques (1H NMR, FTIR, UV-Vis) and elemental analysis, and metalated with Mn and Co acetate salts. The antibacterial and antifungal activities of these compounds in vitro were investigated by agar-disc diffusion method against Escherichia coli (-), Pseudomonas aeruginosa (-), Staphylococcus aureus (+), Bacillus subtilis (+) and Aspergillus oryzae and Candida albicans. Results showed that antibacterial and antifungal activity of the test samples increased with increase of their concentrations and the highest activity was obtained when the concentration of porphyrin compounds was 100 µg/mL. The activity for the porphyrin ligands depended on the nature of the urea derivative substituents and increased in the order P1 > P2 > P3 >P4, which was consistent with the order of their liposolubility. MnP and CoP complexes exhibited much higher antibacterial and antifungal activity than P1-P4ligands. Further, the growth inhibitory effects of these compounds was generally in the order CoP complexes > MnP complexes > P1-P4 ligands. Among these porphyrin compounds, CoP1 displayed the highest antibacterial and antifungal activity, especially with a concentration of 100 µg/mL, against all the four tested bacteria and two fungi, and therefore it could be potential to be used as drug.
Chemistry of Pyrones, Part 3: New Podands of 4H-Pyran-4-ones (2000)

New derivatives of 3,5-disubstituted 4H-Pyran-4-one podands (9-15) were prepared by transesterification reaction of dimethyl or diethyl 2,6-dimethyl-4H-pyran-4-one-3,5-dicarboxylate with some glycol, glycol ethers or by nucleophilic substitution of some phenols or glycol ethers with 3,5-bis (bromomethyl)-2,6-diphenyl-4H-pyran-4-one.
Clock signal distribution network for high speed testers (2003)

A high-speed clock distribution network is described. By analyzing the transient behavior of the pulse signal along a multisection transmission line, the author develops a new impedance-matching methodology to reduce the internal multireflection processes due to the impedance discontinuities in the signal line. By means of the bisection method, the matched transmission line is converted into a single-input, 2/sup n/-output, binary-tree distribution circuit. The circuit is realized on a planar printed-circuit board. Experimental results show that this distribution system can provide equiamplitude, high-fidelity, nonskewed signals to all the output terminals for pulse signal frequency in excess of 800 MHz.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Einleitung (1997)

Vor wenigen Monaten wurden zwei junge Männer zu hohen Haftstrafen durch das Langericht Potsdam verurteilt, die im Juni vergangenen Jahres im brandenburgischen Mahlow zwei schwarze britische Bauarbeiter überfielen, wobei eines der Opfer eine Querschnittslähmung erlitt (vgl. Neue Westfälische vom 3.12.1996).
The nature and evaluation of commercial expert system building tools, revision 1 (1987)

This memorandum reviews the factors that constitute an Expert System Building Tool (ESBT) and evaluates current tools in terms of these factors. Evaluation of these tools is based on their structure and their alternative forms of knowledge representation, inference mechanisms and developer end-user interfaces. Next, functional capabilities, such as diagnosis and design, are related to alternative forms of mechanization. The characteristics and capabilities of existing commercial tools are then reviewed in terms of these criteria.
A Generic Virtual Bus for Hardware Simulator Composition (2009)

The typical interface between hardware components is a standardized bus. This article presents a virtual counterpart for simulated hardware components: a virtual bus on a virtual motherboard. The authors show that reuse of standard components, common with real hardware, can find its analogy in the domain of simulated hardware, making simulators less expensive and more flexible.
Transmission and Establishment of a Persistent Infection of<i>Enterocytozoon bieneusi</i>, Derived from a Human with AIDS, in Simian Immunodeficiency Virus—Infected Rhesus Monkeys (1997)

Enterocytozoon bieneusi is closely linked with chronic diarrhea and wasting in AIDS. Although reported >10 years ago, little is known about the infection and the disease it induces in humans. Duodenal E. bieneusi spores from an AIDS patient were orally transmitted to 2 simian immunodeficiency virus-infected rhesus monkeys. Both animals began shedding spores within a week of inoculation, as confirmed by microscopy and polymerase chain reaction, and continued until euthanatized 7 and 8 months later. E. bieneusi infection in the gut was sparse, either because of moderate numbers of circulating CD4 cells or because monkeys are less susceptible than humans to this infection. This is apparently the first documented transmission of E. bieneusi infection between hosts.
Optimization of filtering schemes for broadband astro-combs (2012)

To realize a broadband, large-line-spacing astro-comb, suitable for wavelength calibration of astrophysical spectrographs, from a narrowband, femtosecond laser frequency comb ("source-comb"), one must integrate the source-comb with three additional components: (1) one or more filter cavities to multiply the source-comb's repetition rate and thus line spacing; (2) power amplifiers to boost the power of pulses from the filtered comb; and (3) highly nonlinear optical fiber to spectrally broaden the filtered and amplified narrowband frequency comb. In this paper we analyze the interplay of Fabry-Perot (FP) filter cavities with power amplifiers and nonlinear broadening fiber in the design of astro-combs optimized for radial-velocity (RV) calibration accuracy. We present analytic and numeric models and use them to evaluate a variety of FP filtering schemes (labeled as identical, co-prime, fraction-prime, and conjugate cavities), coupled to chirped-pulse amplification (CPA). We find that even a small nonlinear phase can reduce suppression of filtered comb lines, and increase RV error for spectrograph calibration. In general, filtering with two cavities prior to the CPA fiber amplifier outperforms an amplifier placed between the two cavities. In particular, filtering with conjugate cavities is able to provide <1 cm/s RV calibration error with >300 nm wavelength coverage. Such superior performance will facilitate the search for and characterization of Earth-like exoplanets, which requires <10 cm/s RV calibration error.
Aqueous proton transfer across single-layer graphene (2015)

Proton transfer across single-layer graphene proceeds with large computed energy barriers and is therefore thought to be unfavourable at room temperature unless nanoscale holes or dopants are introduced, or a potential bias is applied. Here we subject single-layer graphene supported on fused silica to cycles of high and low pH, and show that protons transfer reversibly from the aqueous phase through the graphene to the other side where they undergo acid-base chemistry with the silica hydroxyl groups. After ruling out diffusion through macroscopic pinholes, the protons are found to transfer through rare, naturally occurring atomic defects. Computer simulations reveal low energy barriers of 0.61-0.75 eV for aqueous proton transfer across hydroxyl-terminated atomic defects that participate in a Grotthuss-type relay, while pyrylium-like ether terminations shut down proton exchange. Unfavourable energy barriers to helium and hydrogen transfer indicate the process is selective for aqueous protons.
A Comparison of Gene Set Analysis Methods in Terms of Sensitivity, Prioritization and Specificity (2013)

Identification of functional sets of genes associated with conditions of interest from omics data was first reported in 1999, and since, a plethora of enrichment methods were published for systematic analysis of gene sets collections including Gene Ontology and biological pathways. Despite their widespread usage in reducing the complexity of omics experiment results, their performance is poorly understood. Leveraging the existence of disease specific gene sets in KEGG and Metacore® databases, we compared the performance of sixteen methods under relaxed assumptions while using 42 real datasets (over 1,400 samples). Most of the methods ranked high the gene sets designed for specific diseases whenever samples from affected individuals were compared against controls via microarrays. The top methods for gene set prioritization were different from the top ones in terms of sensitivity, and four of the sixteen methods had large false positives rates assessed by permuting the phenotype of the samples. The best overall methods among those that generated reasonably low false positive rates, when permuting phenotypes, were PLAGE, GLOBALTEST, and PADOG. The best method in the category that generated higher than expected false positives was MRGSE.
A family of short, interspersed repeats is associated with tandemly repetitive DNA in the human genome. (1987)

A family of short, interspersed repeats in the human genome, designated the Mst II family, is described. The canonical structure of the repeat consists of a 220-base-pair (bp) left arm joined to a 160-bp right arm by a 39-bp junction sequence. The right arm is absent in some isolates. Some homology with the "O" and "THE" (transposon-like element) families of repeats was observed, suggesting that the Mst II elements could be a subgroup of a SINE superfamily. The 39-bp junction sequence is tandemly repeated in one of our clones. The association of tandemly repetitive sequences with Mst II elements or the putative superfamily is probably nonrandom; a search of DNA sequence data bases revealed that approximately 80 bp of the Mst II left arm occurs immediately adjacent to the tandem repeat that comprises the human homologue to the BK virus enhancer. The fortuitous occurrence of a gene duplication event involving an Mst II repeat has allowed us to estimate a mutation rate for human DNA.
Sinogram-based coil selection for streak artifact reduction in undersampled radial real-time magnetic resonance imaging (2016)

The proposed method enables a fast reduction of streak artifacts in radial real-time MRI.
CONSTITUTIVE RELATIONS IN THE WETTING OF LOW ENERGY SURFACES AND THE THEORY OF THE RETRACTION METHOD OF PREPARING MONOLAYERS<sup>1</sup> (1960)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCONSTITUTIVE RELATIONS IN THE WETTING OF LOW ENERGY SURFACES AND THE THEORY OF THE RETRACTION METHOD OF PREPARING MONOLAYERS1Elaine G. Shafrin and William A. ZismanCite this: J. Phys. Chem. 1960, 64, 5, 519–524Publication Date (Print):May 1, 1960Publication History Published online1 May 2002Published inissue 1 May 1960https://pubs.acs.org/doi/10.1021/j100834a002https://doi.org/10.1021/j100834a002research-articleACS PublicationsRequest reuse permissionsArticle Views2469Altmetric-Citations387LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Optical Character Recognition (OCR) Performance in Server-Based Mobile Environment (2013)

There are several Optical Character Recognition (OCR) mobile applications on the market running on mobile devices, both android and iOS (iPhone, iPad, iPod) platforms. The limitations of mobile device processor hinder the possible execution of computationally intensive applications that need less time of process. This paper proposes a framework of Optical Character Recognition (OCR) on mobile device using server-based processing. Comparison methods proposed by this paper by conducting a series of tests using standalone and server-based OCR on mobile devices, and compare the results of the accuracy and time required for the entire OCR processing. Server-based mobile OCR obtains 5% higher character recognition accuracy than the standalone OCR and its format recognition accuracy is 99.8%. The framework tries to overcome the limitation of mobile device capability process, so the devices can do the computationally intensive application more quickly.
In Vitro Evaluation of Cytochrome P450 and Glucuronidation Activities in Hepatocytes Isolated from Liver-Humanized Mice (2010)

Cryopreserved human (h-) hepatocytes are currently regarded as the best in vitro model for predicting human intrinsic clearance of xenobiotics. Although fresh h-hepatocytes have greater plating efficiency on dishes and greater metabolic activities than cryopreserved cells, performing reproducible studies using fresh hepatocytes from the same donor and having an "on demand" supply of fresh hepatocytes are not possible. In this study, cryopreserved h-hepatocytes were transplanted into albumin enhancer/promoter-driven, urokinase-type plasminogen activator, transgenic/severe combined immunodeficient (uPA/SCID) mice to produce chimeric mice, the livers of which were largely replaced with h-hepatocytes. We determined whether the chimeric mouse could serve as a novel source of fresh h-hepatocytes for in vitro studies. h-Hepatocytes were isolated from chimeric mice (chimeric hepatocytes), and cytochrome P450 (P450) activities were determined. Compared with cryopreserved cells, the P450 (1A2, 2C9, 2C19, 2D6, 2E1, 3A) activities of fresh chimeric hepatocytes were similar or greater. Moreover, ketoprofen was more actively metabolized through glucuronide conjugates by fresh chimeric hepatocytes than by cryopreserved cells. We conclude that chimeric mice may be a useful tool for supplying fresh h-hepatocytes on demand that provide high and stable phase I enzyme and glucuronidation activities.
Continence-preserving procedures for benign and malignant disease. (1993)

The musculature of the anal sphincter is not involved in ulcerative colitis and is seldom invaded directly by rectal carcinoma. Because the sphincter is capable of preserving a good degree of continence, even after removal of the entire rectum for rectal carcinoma, or even of the entire rectum and colon in ulcerative colitis, it should be preserved in most patients who require surgical treatment for these conditions. This review is primarily concerned with what type of enteric substitute should be used for the excised rectum. It addresses the issues of whether retention of a few centimeters of distal rectum above the anal high pressure zone (when permissible) is of value in patients with rectal carcinoma; whether the entire anal sphincter complex, including the so-called "sampling zone" of anal mucosa, should be preserved in the course of rectal excision for ulcerative colitis; or whether, alternatively, all mucosa above the dentate line should be removed and continuity restored by means of an endoanal, pouch-anal anastomosis. For the patient, the eventual clinical result depends on the quality of the anal sphincter, the physiologic characteristics of the "neorectum," the degree to which anal and rectal function are coordinated, and finally, the judgment and technical skill of the surgeon.
Comparison of Okumura, Hata and COST-231 Models on the Basis of Path Loss and Signal Strength (2012)

Radio propagation is essential for emerging technologies with appropriate design, deployment and management strategies for any wireless network. It is heavily site specific and can vary significantly depending on terrain, frequency of operation, velocity of mobile terminal, interface sources and other dynamic factor. Accurate characterization of radio channel through key parameters and a mathematical model is important for predicting signal coverage, achievable data rates, BER and Antenna gain.
Biological properties of human skin mast cells (1991)

Mast cells and basophils, although sharing many constitutive properties, are quite distinct in their development, functions and biological properties. Mast cell granules are composed of a macromolecular matrix of proteoglycan and neutral protease of which heparin and tryptase, respectively, are predominant. The distribution of the other major neutral protease, chymase, allows human mast cell subpopulations to be subdivided immunocytochemically. All human mast cells respond to IgE-dependent stimulation with the secretion of the preformed mediator, histamine, and the newly generated lipid-derived eicosanoids PGD2 and LTC4. Although amounts of these products vary between mast cells dispersed from different tissues, it is uncertain whether this reflects true heterogeneity. Mast cells of the human skin, but not those of other tissues, are sensitive to stimulation by substance P, compound 48/80 and other basic non-immunological stimuli. The mechanism of mediator secretion induced by these agents is distinct from that induced by IgE-dependent stimulation. However, the morphological characteristics of degranulation are similar, suggesting that the distinct biochemical pathways merge into a common pathway before effecting degranulation.
The GRADE System for Rating Clinical Guidelines (2009)

Brian Kavanagh critiques the GRADE system of grading guidelines, arguing that even though it has evolved through the Evidence-Based Medicine movement, there is no evidence that GRADE itself is reliable.