gebhart/patrepeval huggingface dataset:
A dynamic clustering strategy in a demand paging environment (1976)

An algorithm is presented which dynamically clusters pages of a problem program based on its past program behavior (i.e. reference string patterns) in a demand paged virtual memory environment. The objective of this algorithm is to minimize the number of page faults during execution, while at the same time use memory page frames efficiently. Dynamic clusters of time and reference related pages are built during a program's execution time. Whenever a page fault for the i-th page occurs in this time evolving environment, the pages of the cluster associated with the i-th page is compared to the pages currently in real (physical) memory. Thus during this current page fault, the demanded page, and any associated clustered pages not currently in physical memory are placed into memory. Page frames holding pages not in the current cluster are returned to the memory management system. Thus the physical amount of memory allocated to a processing program is dependent upon the size of the associated cluster at that time . Simulation results of program behavior operating under this dynamic clustering strategy indicates that significant improvements in page faults and in the space time product may be achieved. The algorithm requires fewer real page frames per executed instruction than most currently implemented algorithms that utilize a fixed number of page frames per problem programs (i.e. fixed allocated partition or region). The algorithm, MLMM (Modified Locality Matrix Model), an extension of work by Hedges and Pooch [12] is used to determine inherent program locality to predict independent dynamic program behavior, separating instruction from data references. Furthermore, strength coefficients between weakly or loosely coupled clusters are used to refine the cluster population, identify cluster transitions, as well as indicate the behavior of the cluster formations.
Do endogenous opioids mediate the relationship between blood pressure and pain sensitivity in normotensives? (1994)

Elevated resting blood pressure is associated with decreased pain sensitivity in both animals and humans. Recent evidence suggests that this relationship may be mediated by endogenous opioid peptides in hypertensives, but the precise mechanism has not been investigated in normotensives. We examined the effect of opioid receptor blockade with naloxone on the relationship between resting blood pressure and pain sensitivity in normotensive humans. Sixteen young adults were given cold pressor and handgrip challenges after treatment with either naloxone or saline in a placebo-controlled, within-subject design. Multiple regression procedures indicated that resting systolic blood pressure was a significant predictor of cold pain ratings even after the effects of naloxone were statistically controlled. The interaction between systolic blood pressure and opioid blockade was non-significant. These data suggest that the relationship between resting blood pressure and pain sensitivity in normotensive humans is mediated, at least in part, by non-opioid mechanisms.
Fluoride-ion mediated reaction between trimethylsilylacetonitrile and carbonyl compounds. A new synthesis of β-trimethylsilyloxy nitrites (1989)

C. Palomo, J. M. Aizpurua, M. C. López and B. Lecea, J. Chem. Soc., Perkin Trans. 1, 1989, 1692 DOI: 10.1039/P19890001692
Rabbit C-reactive protein. Biosynthesis and characterization of cDNA clones. (1986)

To study the biosynthesis of rabbit C-reactive protein (CRP), a cDNA library was constructed from CRP mRNA-enriched polysomal poly(A) RNA. Four recombinant plasmids, designated pCX9, pCX23, pCX28, and pCX39, from 39 positive clones were sequenced and found to represent overlapping clones. DNA sequencing of CRP cDNA and primer extension of the 5'-end of CRP mRNA have demonstrated that the complete length of rabbit CRP mRNA consists of 2331 nucleotides and a terminal poly(A) segment. Analysis of the resulting sequence indicated that rabbit CRP mRNA contained a 5'-noncoding region of 107 nucleotides, a leader sequence encoding 20 amino acids, a coding region covering 205 amino acids, and a 3'-noncoding region of 1549 nucleotides. The 3'-noncoding region contained a consensus AAUAAA sequence that is 105 nucleotides upstream from the 3'-terminal poly(A) segment. Using an in vitro translation system, we have confirmed that CRP is synthesized as a precursor polypeptide (Mr approximately equal to 26,000) which undergoes processing to form the mature polypeptide (Mr approximately equal to 23,500). The CRP precursor failed to display a calcium-dependent affinity for phosphorylcholine ligand as demonstrated by mature CRP, suggesting that the phosphorylcholine-binding site of CRP only formed after processing. Northern blot analysis suggested that following induction with turpentine, liver was the only site where CRP mRNA synthesis could be demonstrated and that the change in mRNA concentration correlated with the course of CRP production. Southern blot analysis of liver genomic DNA indicated a single gene copy for CRP.
Capsaicin mimics mechanical load-induced intracellular signaling events (2013)

Mechanical load-induced intracellular signaling events are important for subsequent skeletal muscle hypertrophy. We previously showed that load-induced activation of the cation channel TRPV1 caused an increase in intracellular calcium concentrations ([Ca ( 2+) ]i) and that this activated mammalian target of rapamycin (mTOR) and promoted muscle hypertrophy. However, the link between mechanical load-induced intracellular signaling events, and the TRPV1-mediated increases in [Ca ( 2+) ]i are not fully understood. Here we show that administration of the TRPV1 agonist, capsaicin, induces phosphorylation of mTOR, p70S6K, S6, Erk1/2 and p38 MAPK, but not Akt, AMPK or GSK3β. Furthermore, the TRPV1-induced phosphorylation patterns resembled those induced by mechanical load. Our results continue to highlight the importance of TRPV1-mediated calcium signaling in load-induced intracellular signaling pathways.
Biased and Unbiased Technological Change (2008)

This article provides working definitions of biased and unbiased technological change based on the relative responses of the marginal products of capital and labour that occur in the face of economic shocks. These Hicksian definitions are distinguished from others that focus on how technology augments the production function. The bias and augmentation of technical progress are then linked through the substitutability of labour and capital. Examples of ‘labour-biased’ and ‘capital-biased’ technological change from the 19th century to the present illustrate these ideas.
El escritor y los libros en tiempos de crisis (1996)

Heading date is a key trait in rice domestication and adaption, and a number of quantitative trait loci (QTLs) have been identified. The rice (Oryza sativa L.) cultivars in the Heilongjiang Province, the northernmost region of China, have to flower extremely early to fulfill their life cycle. However, the critical genes or different gene combinations controlling early flowering in this region have not been determined. QTL and candidate gene analysis revealed that Hd2/Ghd7.1/OsPRR37 plays a major role in controlling rice distribution in Heilongjiang. Further association analysis with a collection of rice cultivars demonstrated that another three major QTL genes (Hd4/Ghd7, Hd5/DTH8/Ghd8, and Hd1) also participate in regulating heading date under natural long day (LD) conditions. Hd2/Ghd7.1/OsPRR37 and Hd4/Ghd7 are two major QTLs and function additively. With the northward rice cultivation, the Hd2/Ghd7.1/OsPRR37 and Hd4/Ghd7 haplotypes became non-functional alleles. Hd1 might be non-functional in most Heilongjiang rice varieties, implying that recessive hd1 were selected during local rice breeding. Non-functional Hd5/DTH8/Ghd8 is very rare, but constitutes a potential target for breeding extremely early flowering cultivars. Our results indicated that diverse genetic combinations of Hd1, Hd2, Hd4, and Hd5 determined the different distribution of rice varieties in this northernmost province of China.
Dynamics of Human Voluntary Accommodation (1988)

Voluntary and reflex accommodation were measured monocularly in five normal subjects using a dynamic infrared optometer. Comparison of the peak velocity/amplitude relation (i.e., "main sequence") showed complete overlapping of the response distributions, suggesting similarity of motoneuronal controller signals for voluntary and reflex accommodation. Voluntary accommodation may represent a preprogrammed maneuver used in a variety of real-life predictable situations to optimize performance. Clinically, it may represent an important component in the training of accommodation dynamics.
A Microwave Radiation Monitor (1976)

A microwave radiation monitor designed for rapid measurement of microwave power density in the field is described. The instrument incorporates a broad-band spiral antenna whose design is based on a knowledge of the field pattern of a circular loop antenna. The power induced in the spiral by the radiation raises the temperature of a microbead thermistor in an electric circuit. This rise in temperature is a measure of the power density which is indicated directly on a meter.
A Novel Approach to in situ Proteome Analysis Using Chemical Inkjet Printing Technology and MALDI-QIT-TOF Tandem Mass Spectrometer (2006)

Proteomics data obtained by mass spectrometry are now being combined with spatial information. This report outlines a digestion procedure for tissue sections on polyvinylidenfluoride membrane and results of a direct tandem mass spectrometry of mouse brain sections in situ. We succeeded in sequencing the digested peptides such as myelin basic protein, histon H2A, and tubulin β4 directly from tissue sections and transferred membrane. Protein blotting method can provide protein denaturation during the transfer process with electrode heat and with detergent contained in a transfer buffer. In addition to denaturing proteins, chemical inkjet printing technology and a highly sensitive matrix-assisted laser desorption/ionization quadrupole-ion-trap time-of-flight tandem mass spectrometer enabled us to print solutions of enzyme in micro-scale areas on the membranes and obtain high quality data in mass spectrometry/mass spectrometry. This analytical methodology will provide an innovative approach to in situ proteome analysis.
Sensitivity of piezoelectric sensors fabricated with various types of commercial PZT powder (2013)

This article describes the research on the characteristics of various grades of PZT ceramic powder for use in the manufacture of piezoelectric paint. Batches of water-based acrylic paint were made using these lead zirconate titanate powders and evaluated according to their effectiveness as a paint and the quality of the piezoelectric sensors made from them. Four types of nominally similar PZT (Navy type II) were tested, and a clear conclusion drawn that Piezo Kinetics PKI-502 was the best in this application.
Effects of Movement and Postural Positionsin Spinal Cord Stimulation in the NewRechargeable Systems (2014)

The findings of the present work are similar to those described in previous publications that showed the relationship between postural changes and several stimulation thresholds and pulse energy. The posture which requires lower energy - and whose corresponding therapeutic range (TR) is narrower--is supine decubitus.
Preventing neuronal damage and inflammation<i>in vivo</i>during cortical microelectrode implantation through the use of Poloxamer P-188 (2013)

These findings are the first to suggest that Poloxamer has neuroprotective effects in vivo; however, at a fixed loading dose, these effects are limited to approximately 1 month post-implantation.
Similarity between the 38-kilodalton lipoprotein of Treponema pallidum and the glucose/galactose-binding (MglB) protein of Escherichia coli (1994)

The recent discovery that abundant and immunogenic lipoproteins constitute the integral membrane proteins of Treponema pallidum has prompted efforts to investigate their importance in the physiology and ultrastructure of the organism and in immune responses during infection. Earlier studies identified a 38-kDa lipoprotein of T. pallidum believed to be specific to the pathogen. In the present study, monoclonal antibodies generated against the 38-kDa lipoprotein of T. pallidum reacted with cognate 37-kDa molecules in the nonpathogens Treponema phagedenis, Treponema denticola, and Treponema refringens. Cloning and expression of the 38-kDa-lipoprotein gene of T. pallidum in Escherichia coli revealed that the recombinant product displayed a slightly larger (39-kDa) apparent molecular mass but remained reactive with anti-38-kDa-protein monoclonal antibodies. The recombinant product was processed and acylated in E. coli. DNA and amino acid sequence analyses indicated an open reading frame encoding 403 amino acids, with the first 25 amino acids corresponding to a leader peptide terminated by a signal peptidase II processing site of Val-Val-Gly-Cys. The predicted mature protein is 378 amino acids in length with a deduced molecular weight of 40,422 (excluding acylation). Southern blotting failed to demonstrate in nonpathogenic treponemes genomic sequences homologous with the 38-kDa-lipoprotein gene of T. pallidum. Computer analysis revealed that the 38-kDa lipoprotein of T. pallidum had 34.2% identity and 58.9% similarity with the glucose/galactose-binding protein (MglB) of E. coli and Salmonella typhimurium. Furthermore, of the 19 amino acids of MglB involved in carbohydrate binding, the 38-kDa lipoprotein had identity with 11. These studies have allowed the first putative functional assignment (carbohydrate binding) to a T. pallidum integral membrane protein. Recognition of this potential physiological role for the 38-kDa lipoprotein underscores the possibility that the membrane biology of T. pallidum may more closely resemble that of gram-positive organisms, which also utilize lipoproteins as anchored transporters, than that of gram-negative bacteria to which T. pallidum often is analogized.
Creating a reusable GUI component (2002)

Abstract Application development of a large number of graphical user interface (GUI) screens and reports requires a labor‐intensive process. In the typical scenario, a GUI developer drags each component, such as the textfield, label, and error messages, on each of the new GUI screens or reports. They then set the component properties and perhaps write any validation routines for input data. Using the proposed Observation Panel Bean (OPB), the developer drags only one component per field, and the OPB dynamically builds the GUI components with consistent properties and links the observation field to the needed validation routine. With little development effort these fields are simply selected from the data dictionary and placed on the GUI. The proposed OPB uses Fowler's observation pattern as a high‐level abstraction representing attributes observed about information in the application domain. The panel collaborates with the observation pattern to set the label, error message, and properties of the various components. Yoder's validator pattern collaborates with the observation pattern and the data dictionary to validate the observations. The proposed OPB decreases GUI development time, adds adaptability to GUI design, and increases consistency in GUI component presentation. Copyright © 2002 John Wiley & Sons, Ltd.
Process minimization: Making plants safer (2000)

Minimization, a key inherent safety technique, can lessen the consequences of potential mishaps via reducing hazardous inventories, reactor sizes, and even pipe diameters.
Regulation of intracellular pH in eukaryotic cells (1988)

Research Article| February 15 1988 Regulation of intracellular pH in eukaryotic cells I H Madshus I H Madshus 1Department of Biochemistry, Norwegian Radium Hospital, Montebello, Oslo. Search for other works by this author on: This Site PubMed Google Scholar Author and article information Publisher: Portland Press Ltd Online ISSN: 1470-8728 Print ISSN: 0264-6021 © 1988 London: The Biochemical Society1988 Biochem J (1988) 250 (1): 1–8. https://doi.org/10.1042/bj2500001 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation I H Madshus; Regulation of intracellular pH in eukaryotic cells. Biochem J 15 February 1988; 250 (1): 1–8. doi: https://doi.org/10.1042/bj2500001 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. © 1988 London: The Biochemical Society1988 Article PDF first page preview Close Modal You do not currently have access to this content.
The aromatase inhibitors in early breast cancer: who, when, and why? (2005)

The aromatase inhibitors deplete oestrogen by inhibiting aromatase, the enzyme that synthesises oestrogen from androgens. They are effective as therapies for breast cancer only in postmenopausal women whose tumours express oestrogen or progesterone receptors. As adjuvant therapy, tamoxifen and the aromatase inhibitors have similar efficacy in the first 5 years of treatment. Aromatase inhibitors can be used as an alternative to tamoxifen in women with symptomatic intolerance or a contraindication to tamoxifen. Early data suggest that switching to an aromatase inhibitor after 2-5 years of tamoxifen therapy is beneficial in women with high-risk disease. Aromatase inhibitors are associated with more hot flushes than placebo, but with fewer hot flushes, less endometrial toxicity and venous thromboembolism, and more arthralgia, myalgia and bone fracture than tamoxifen.
Novel Polymeric Dispersants for Water Dispersible Granules (2001)

High concentration extruded water dispersible granules (WG) can be processed using styrene acrylic and modified styrene acrylic dispersants at formulation concentrations usually found in wettable powder formulations: 3–7 % (w/w). These dispersants have found application with a wide range of active ingredients at concentrations ranging from 75% to &gt;90% (w/w) of technical grade active ingredient. Extruded granule formulations containing these dispersants demonstrate excellent granule disintegration and physical suspension upon dilution both initially and upon extended storage at elevated temperatures. Experimental design techniques have also been identified which dramatically shorten the product development time frame.
An anti-idiotype vaccine for AIDS based on the HIV receptor. (1991)

Idiotype studies have been important in our study of the HIV/CD4 interaction. They have predicted the binding site on CD4 and showed that it is the same amongst all HIV-I isolates, and therefore a formidable candidate for the design of effective therapeutic and vaccine strategies against HIV. Future research could implicate an anti-idiotype approach to a prophylactic vaccine. It is important to note that an anti-idiotype response may be needed to prime an immune response against a viral epitope which may be used as a secondary component. The use of anti-idiotype responses in infected persons may be able to tip the balance of the immune system so that the body is able to control HIV infection. Until recently the use of anti-idiotypic approaches in the design of HIV vaccines has been sadly neglected.
Multicomponent induction response in a borehole environment (2003)

Abstract Field and numerically simulated data show that coplanar induction measurements (σxx and σyy) are affected by both conductive and resistive muds. The effect is, for a resistivity contrast of 10 or less between the formation and mud, approximately proportional to the resistivity contrast. The borehole effect is generally stronger for a decentralized tool. In the perpendicular eccentricity mode, the eccentricity effect on σxx or σyy can be greater than 100% of the true formation responses. We demonstrate that dual-frequency processing can reduce the eccentricity effect by an order of magnitude. We investigate the effect of invasion for both circular and elliptic invasions. For circular invasion, the effect on σxx, σyy, or the coaxial measurement (σzz) is characterized by a critical invasion thickness. For invasion thinner than the critical thickness, the effect is minimal. The effect increases rapidly as invasion thickness increases beyond the critical thickness. For elliptic invasion, both the σxx and σzz responses are similar to those of the corresponding inner circular invasion. Beyond a long-to-short-axis ratio of three, an elliptic invasion behaves like a long, thin fracture.
Multistage digital prefiltering of noisy tachometer signals (1988)

A multistage digital prefiltering concept is discussed. The prefilter is implemented by using multirate signal-processing techniques, and contains both linear and nonlinear subfilters. The impulsive and wideband noise components are attenuated by a cascade of a standard median filter (SMF) and a low-order Hanning window (HW). A multirate digital filter is used to attenuate the 50/60-Hz power line frequency and its harmonics. The multirate principle with oversampling and decimation is used to reduce the complexity of the required analog antialiasing filter. The multistage filter was tested in a simulation environment and the results were satisfactory.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Color-based tracking of heads and other mobile objects at video frame rates (2002)

We develop a simple and very fast method for object tracking based exclusively on color information in digitized video images. Running on a Silicon Graphics R4600 Indy system with an IndyCam, our algorithm is capable of simultaneously tracking objects at full frame size (640/spl times/480 pixels) and video frame rate (30 fps). Robustness with respect to occlusion is achieved via can explicit hypothesis-tree model of the occlusion process. We demonstrate the efficacy of our technique in the challenging task of tracking people, especially tracking human heads and hands.
La barbarie del Sur. El otro Holocausto. (2000)

Una exposicion en Nueva York recuerda uno de los episodios mas vergonzosos de la historia de Estados Unidos: los linchamientos. Se convirtieron en excursiones de fin de semana para los blancos surenos y en la pesadilla de los negros. La jauria Humana