gebhart/patrepeval huggingface dataset:
New process integration methods for heat-saving retrofit projects in industrial systems (2005)

New graphical methods for HEN retrofit (further development of existing tools), release of usable excess heat and placement of supply tanks in HWWS systems have been developed. In addition, further development of the matrix method for HEN retrofit has been made. The methods have been used in case studies, both as stand-alone tools, and in different combinations.Using the advanced composite curves in combination with the matrix method in HEN retrofit give new insights on which units should be picked for retrofit, and how far the heat recovery should proceed. The extra information that has to be collected to show the placement of existing heaters and coolers give valuable inputs to this method. Calculations showed that heaters and coolers placed close to the pinch are often cheaper by a factor of two and more to retrofit.A method to show the potential to release usable excess heat at high temperature levels (but still below the pinch) has been developed. This method is based on the full set of stream data from the process, and therefore shows the total potential. Case studies have shown that much of the potential is also possible to release by making changes in the HEN with acceptable investments and PBPs.Another method, to be used in HWWS systems for different setups of tanks and different values of DTmin has also been developed. This method shows the potential usable excess heat versus temperature in this sub-system for a user-defined number of supply tanks and DTmin.By studying this sub-system, a large amount of the total potential can be exploited. This leaves the remaining process without any changes at all.A new optimisation routine has been developed and implemented into the matrix method. This method uses a recursive branch and bound algorithm to explore all relevant paths in the retrofit task. A first solution is made and taken as an upper bound to the problem. All following paths that exceed this bound is directly eliminated. The implementation has proven to be reliable and fast to use, although there are still improvements to be made.
Widely-tunable electroabsorption-modulated sampled grating DBR laser (2002)

We demonstrate the first widely-tunable, 2.5 Gb/s transmitter based on an SG-DBR laser monolithically integrated with an SOA and EA modulator. Time-averaged powers in excess of 3 dBm across a 38 nm tuning range have been achieved.
The IGF Pathway Regulates ERα through a S6K1-Dependent Mechanism in Breast Cancer Cells (2011)

The IGF pathway stimulates malignant behavior of breast cancer cells. Herein we identify the mammalian target of rapamycin (mTOR)/S6 kinase 1 (S6K1) axis as a critical component of IGF and estrogen receptor (ER)α cross talk. The insulin receptor substrate (IRS) adaptor molecules function downstream of IGF-I receptor and dictate a specific biological response, in which IRS-1 drives proliferation and IRS-2 is linked to motility. Although rapamycin-induced mTOR inhibition has been shown to block IGF-induced IRS degradation, we reveal differential effects on motility (up-regulation) and proliferation (down-regulation). Because a positive correlation between IRS-1 and ERα expression is thought to play a central role in the IGF growth response, we investigated the potential role of ERα as a downstream mTOR target. Small molecule inhibition and targeted knockdown of S6K1 blocked the IGF-induced ERα(S167) phosphorylation and did not influence ligand-dependent ERα(S118) phosphorylation. Inhibition of S6K1 kinase activity consequently ablated IGF-stimulated S6K1/ERα association, estrogen response element promoter binding and ERα target gene transcription. Moreover, site-specific ERα(S167) mutation reduced ERα target gene transcription and blocked IGF-induced colony formation. These findings support a novel link between the IGF pathway and ERα, in which the translation factor S6K1 affects transcription of ERα-regulated genes.
Application of Machine Learning and Crowdsourcing to Detection of Cybersecurity Threats (2018)

We are applying machine learning and crowdsourcing to cybersecurity, with the purpose to develop a toolkit for detection of complex cyber threats, which are often undetectable by traditional tools. It will serve as an “extra layer of armor” that supplements the standard defenses. The initial results include (1) an architecture for sharing security warnings among users and (2) machine learning techniques for identifying malicious websites. The public release of the developed system is available at http://cyberpsa.com. This project is part of the work on advanced data analysis at the CCICADA Center of Excellence.
Biophysics of Parkinsons Disease: Structure and Aggregation of &#945;- Synuclein (2009)

Parkinson's disease (PD) is a slowly progressive movement disorder that results from the loss of dopaminergic neurons in the substantia nigra, a small area of cells in the mid-brain. PD is a multifactorial disorder with unknown etiology, in which both genetic and environmental factors play important roles. Substantial evidence links alpha-synuclein, a small highly conserved presynaptic protein with unknown function, to both familial and sporadic PD. Rare familial cases of PD are associated with missense point mutations in alpha-synuclein, or with the hyper-expression of the wild type protein due to its gene duplication/triplication. Furthermore, alpha-synuclein was identified as the major component of amyloid fibrils found in Lewy body and Lewy neurites, the characteristic proteinaceous deposits that are the diagnostic hallmarks of PD. alpha-Synuclein is abundant in various regions of the brain and has two closely related homologs, beta-synuclein and gamma-synuclein. When isolated in solution, the protein is intrinsically disordered, but in the presence of lipid surfaces alpha-synuclein adopts a highly helical structure that is believed to mediate its normal function(s). A number of different conformational states of alpha-synuclein have been observed. Besides the membrane-bound form, other critical conformations include a partially-folded state that is a key intermediate in aggregation and fibrillation, various oligomeric species, and fibrillar and amorphous aggregates. A number of intrinsic and extrinsic factors that either accelerate or inhibit the rate of alpha-synuclein aggregation and fibrillation in vitro are known. There is a strong correlation between the conformation of alpha-synuclein (induced by various factors) and its rate of fibrillation. The aggregation process appears to be branched, with one pathway leading to fibrils and another to oligomeric intermediates that may ultimately form amorphous deposits. The molecular basis of Parkinson's disease appears to be tightly coupled to the aggregation of alpha-synuclein and the factors that affect its conformation. This review focuses on the contributions of Prof. Anthony L. Fink to the field and presents some recent developments in this exciting area.
Wide-band microstrip patch antenna design for LMDS band (2000)

There has been a constant effort to study methods for increasing the bandwidth of microstrip antennas. In this paper, we propose a special type of the external rectangular patch, for the design and analysis of an antenna using a local multipoint distribution system (LMDS). We minimized electromagnetic emissions from the fringing effect. As a result, we obtained an increase in antenna efficiency and frequency bandwidth. We were also able to design the wideband antenna easily, because of the difference in parameter between the aimed and the simulated antenna was reduced greatly. In comparison with the rectangular patch antenna, the banded one has a wider bandwidth. We set the operation frequency bandwidth from 24.5 GHz to 28.5 GHz on the basis of the operation frequency band at VSWR 2.0, and used a Teflon substrate with relative dielectric ratio is 2.6.
Optimization of Correlated Multiple Quality Characteristics Using Desirability Function (2004)

A real problem in a product or process usually possesses multiple quality characteristics. For the multiple quality characteristics optimization problem, the most popular method for simultaneous quality characteristics optimization is the desirability function approach. However, the variation and correlation between quality characteristics are usually ignored in this approach. The variation reduction through robust design introduced by Taguchi is a major concept. This research presents an approach to optimizing the correlated multiple quality characteristics based on the modified double-exponential desirability function. The implementation and the effectiveness of the proposed approach are illustrated through two examples from previously published articles.
Sensitive magnetic sensors using amorphous Wiegand-type ribbons (1981)

New sensitive bistable magnetic sensors are presented using amorphous magnetostrictive ribbons. These Wiegand-type ribbons induce symmetrical sharp voltage pulses with 20-50 microsecond width at the half amplitude against the sinusoidal exciting field of more than 1.2 Oe and 0.1 Hz - 6 kHz. The domain nucleation field is about 0.6 Oe, which is about 1/50 that of the Wiegand wires. Straight and curved shape cores for magnetic sensors are easily designed using the amorphous bistable ribbons.
Efficiently finding web services using a clustering semantic approach (2008)

Efficiently finding Web services on the Web is a challenging issue in service-oriented computing. Currently, UDDI is a standard for publishing and discovery of Web services, and UDDI registries also provide keyword searches for Web services. However, the search functionality is very simple and fails to account for relationships between Web services. Firstly, users are overwhelmed by the huge number of irrelevant returned services. Secondly, the intentions of users and the semantics in Web services are ignored. Inspired by the success of partitioning approach used in the database design, we used a novel clustering semantic algorithm to eliminate irrelevant services with respect to a query. Then we utilized Probabilistic Latent Semantic Analysis (PLSA), a machine learning method, to capture the semantics hidden behind the words in a query, and the descriptions in the services, so that service matching can be carried out at the concept level. This paper reports upon the preliminary experimental evaluation that shows improvements over recall and precision.
Mechanism of deoxyadenosine and 2-chlorodeoxyadenosine toxicity to nondividing human lymphocytes. (1985)

Deoxyadenosine has been implicated as the toxic metabolite causing profound lymphopenia in immunodeficient children with a genetic deficiency of adenosine deaminase (ADA), and in adults treated with the potent ADA inhibitor deoxycoformycin. However, the biochemical basis for deoxyadenosine toxicity toward lymphocytes remains controversial. The present experiments have examined in detail the sequential metabolic changes induced in nondividing human peripheral blood lymphocytes by incubation with deoxyadenosine plus deoxycoformycin, or with 2-chlorodeoxyadenosine (CdA), an ADA resistant deoxyadenosine congener with anti-leukemic and immunosuppressive properties. The lymphotoxic effect of deoxyadenosine and CdA required their phosphorylation, and was inhibited by deoxycytidine. As early as 4 h after exposure to the deoxynucleosides, strand breaks in lymphocyte DNA began to accumulate, and RNA synthesis decreased. These changes were followed by a significant fall in intracellular NAD levels at 8 h, a drop in ATP pools at 24 h, and cell death by 48 h. Incubation of the lymphocytes with 5 mM nicotinamide, a NAD precursor and an inhibitor of poly(ADP-ribose) synthetase, prevented NAD depletion. The nicotinamide treatment also rendered the lymphocytes highly resistant to deoxyadenosine and CdA toxicity, without altering dATP formation or the accumulation of DNA strand breaks. The poly(ADP-ribose) synthetase inhibitor 3-aminobenzamide exerted a similar although less potent effect. These results suggest that NAD depletion, probably triggered by poly(ADP-ribose) formation, is the principle cause of death in normal resting human lymphocytes exposed to deoxyadenosine plus deoxycoformycin, or to CdA.
Prospects for Using  C 60 and  C 70 in Lithium Batteries (1991)

Solid films of C60 and C70 fullerenes are evaluated in propylene carbonate/lithium perchlorate, an electrolyte commonly used in lithium batteries. Cyclic voltammetry, chronopotentiometry, and an effusion test, show that reduced C60 and C70 are soluble in the electrolyte tested, which, coupled with poor stability of the highly reduced material and poor electrochemical reversibility, would compromise the performance of secondary batteries based on these fullerenes.
Simple chromatic dispersion measurement method using a spectral interferometer (2007)

We present a novel chromatic dispersion measurement method using a spectral domain interferometer for single mode optical fiber over a wide spectral range (200 nm). This technique is based on the Mach-Zehnder interferometer using a white light source and spectrometer. A phase was directly retrieved from a measured spectral interferogram to obtain relative group velocity, chromatic dispersion and dispersion slope. The measured results with the proposed method were compared with those obtained using a conventional measurement method. Those results have good agreement with each other. Our proposed method can simply, accurately, and quickly (< 500 ms) measure chromatic information for a short length of optical fiber as well as optical devices.
Diagnosis and Management in Vision Care (1987)

The Problem-Solving Approach to Patient Care Headache Light Sensitivity Light Flashes and Floaters Hyperopia Myopia Anisometropia and Aniseikonia Presbyopia Low-Power Lenses The Dissatisfied Refractive Patient The Eye Not Correctable to 20/20 Induced Refractive and Visual Changes Refractive Amblyopia Ocular Hysteria and Malingering Accommodative Dysfunction Horizontal Deviations Monocular Diplopia Age-Related Cataract Aphakia and Pseudophakia Color Deficiency Reassurance Therapy
A Data Placement Scheme with Time-Related Model for P2P Storages (2007)

Maintaining desired data availability while minimizing costs is the primary challenge in designing P2P storages. Data placement schemes and data availability calculation methods are two key design choices. Prior work has used the random placement and steady-state availability analysis model widely. We find this approach has two drawbacks: (1) it ignores the time-related property and greatly underestimates data availability in the short term and (2) it ignores differences in peers' availability and uses a mean value, which also leads to the underestimation of data availability. Both of these drawbacks influence the efficiency of storage and bandwidth resource usage. Also, this approach can not ensure all the objects achieve their expected availability due to the second drawback. This paper develops a different data placement scheme called similar-MTTF-MTTR placement, which takes into consideration differences in pees' dynamic characteristics. Under this scheme, this paper also presents a fine-gained analysis model for short-term data availability calculation. As a result, our scheme improves the efficiency of data maintaining significantly. We validate this by comparing with random placement under three different dynamic environments: a wide-area system (PlanetLab), a corporative environment (desktop personal computers at Microsoft Corporation), and a file-sharing system (Maze). The results show that our scheme can save the storage resource usage significantly under all environments.
The use of calcium sulphate in the surgical treatment of a ‘through and through’ periradicular lesion (2001)

The results of the study demonstrate that the addition of calcium sulphate as a bone graft during the conventional surgical treatment of through and through lesions improves the clinical outcome. Histological analysis is desirable to investigate the quality of tissues formed using the two surgical procedures.
Synthesis and Characterization of Water‐Soluble Conjugated Glycopolymer for Fluorescent Sensing of Concanavalin A (2010)

A neutral polyfluorene derivative that contains 20 mol% 2,1,3-benzothiadiazole (BT) is synthesized by Suzuki cross-coupling polymerization. A cationic conjugated polymer A and an alpha-mannose-bearing polymer B are subsequently obtained through different post-polymerization methods. As a result of the charged pendant groups or sugar-bearing groups attached to the polymer side chains, both A and B show good water-solubility. The titration of Concanavalin A (Con A) into polymer aqueous solution leads to different fluorescent responses for polymers A and B. Polymer A does not show any obvious fluorescence change upon interaction with Con A, whereas polymer B shows fluorescence increase in BT emission intensity when Con A is added. This is because of the specific interaction between alpha-mannose and Con A, which induces polymer aggregation, and then facilitates energy transfer from the phenylene-fluorene segments to the BT units. A practical calibration curve ranging from 1 nM to 250 nM is obtained by correlating the changes in BT emission intensity with Con A concentration. The advantage of polymer B-based Con A macromolecular probe is that it shows signal increase upon Con A recognition, which is significantly different from other conjugated polymer-based fluorescence quenching assays.
Nocturnal dipping behaviour in normotensive white children and young adults in response to changes in salt intake (2010)

Normotensive children and young adults maintain normal nocturnal BP dipping irrespective of salt intake and of individual salt sensitivity. Thus, daytime BP assessment is sufficient to characterize salt responsiveness in normotensive individuals.
Genetic polymorphisms of the XPG and XPD nucleotide excision repair genes in sarcoma patients (2006)

There are more than 50 subtypes of soft tissue sarcomas, among which 30% are associated with specific genetic alterations, including translocations. Several studies have reported associations between cancer risk and polymorphisms of DNA repair genes from the nucleotide excision repair (NER) pathway. NER involves more than 20 proteins whose inactivation leads to xeroderma pigmentosum (XP) or cockayne syndrome (CS), among which XPD, a helicase allowing DNA strand excision by the endonuclease XPG. DNA from 93 patients with synovial sarcomas, myxoid liposarcomas, dermatofibrosarcomas protuberans (DFSP), malignant fibrous histiocytomas and leiomyosarcomas were genotyped for both XPD Lys751Gln and XPG Asp1104His polymorphisms. Departure from Hardy-Weinberg was highly significant for the XPG polymorphism with an excess of heterozygotes in synovial sarcomas (p = 1.5 x 10(-5)), myxoid liposarcomas (p = 1.5 x 10(-4)) and to a lesser extent in DFSP (p = 0.028). In the case of XPD, a significant deviation was observed in synovial sarcomas (p = 3 x 10(-6)) and DFSP (p = 0.0014). When tumors were pooled according to their genetic alterations, the proportion of carriers of the variant XPG allele was significantly increased in sarcomas with specific translocations as compared to sarcomas with complex genetics (p < 10(-9)). No difference was found for XPD. Genotyping of the tumor samples in synovial sarcomas and myxoid liposarcomas revealed frequent loss of heterozygosity for XPG, mostly due to the loss of the frequent allele. For XPD, both alleles were lost with a similar frequency. Our results raise the potential implication of the XPG Asp1104His polymorphism in the occurrence of chromosomal translocations associated with specific subtypes of sarcomas.
Aggregation Propensity of the Human Proteome (2008)

Formation of amyloid-like fibrils is involved in numerous human protein deposition diseases, but is also an intrinsic property of polypeptide chains in general. Progress achieved recently now allows the aggregation propensity of proteins to be analyzed over large scales. In this work we used a previously developed predictive algorithm to analyze the propensity of the 34,180 protein sequences of the human proteome to form amyloid-like fibrils. We show that long proteins have, on average, less intense aggregation peaks than short ones. Human proteins involved in protein deposition diseases do not differ extensively from the rest of the proteome, further demonstrating the generality of protein aggregation. We were also able to reproduce some of the results obtained with other algorithms, demonstrating that they do not depend on the type of computational tool employed. For example, proteins with different subcellular localizations were found to have different aggregation propensities, in relation to the various efficiencies of quality control mechanisms. Membrane proteins, intrinsically disordered proteins, and folded proteins were confirmed to have very different aggregation propensities, as a consequence of their different structures and cellular microenvironments. In addition, gatekeeper residues at strategic positions of the sequences were found to protect human proteins from aggregation. The results of these comparative analyses highlight the existence of intimate links between the propensity of proteins to form aggregates with beta-structure and their biology. In particular, they emphasize the existence of a negative selection pressure that finely modulates protein sequences in order to adapt their aggregation propensity to their biological context.
Computationally Sound Compositional Logic for Key Exchange Protocols (2006)

We develop a compositional method for proving cryptographically sound security properties of key exchange protocols, based on a symbolic logic that is interpreted over conventional runs of a protocol against a probabilistic polynomial-time attacker. Since reasoning about an unbounded number of runs of a protocol involves induction-like arguments about properties preserved by each run, we formulate a specification of secure key exchange that is closed under general composition with steps that use the key We present formal proof rules based on this game-based condition, and prove that the proof rules are sound over a computational semantics. The proof system is used to establish security of a standard protocol in the computational model
Rapeseed: Constituents and protein products Part I. Composition and properties of proteins and glucosinolates (1983)

Abstract The review concerns with value‐determining nonlipidic components from rapeseed, especially the structure, the content and the distribution of proteins and glucosinolates in different species and varieties. Furthermore structural changes and their effects on the composition and properties are summarized.
1135. A study of hydrogen bonding in poly(diorganosiloxane)-αω-diols (1963)

G. I. Harris, J. Chem. Soc., 1963, 5978 DOI: 10.1039/JR9630005978
Use of propranolol in treating hemangiomas. (2011)

Most infantile hemangiomas resolve spontaneously without any need for therapy. In many case series, propranolol has been shown to be effective and safe in treating hemangiomas that cause complications. Further studies are required to determine the optimal dose and duration of propranolol treatment for problematic hemangiomas.
Cell cycle control and cancer. (2001)

Cell cycle control and cancer. Cancer is a multifaceted disease, but a common feature of most tumours is that. they harbour one or more genetic mutations that allow them to proliferate outside their normal growth restraints. Proliferation is normally restrained through control of the cell division cycle, which in turn, is regulated by the Cdk family of serine/threonine kinases and their regulatory partners the cyclins. Here, the roles of the Cdk/cyclin complexes in cell cycle control are described followed by a review of the genetic lesions in these and associated proteins which may contribute to tumour progression.