gebhart/patrepeval huggingface dataset:
Selenocysteine, identified as the penultimate C-terminal residue in human T-cell thioredoxin reductase, corresponds to TGA in the human placental gene. (1996)

The possible relationship of selenium to immunological function which has been suggested for decades was investigated in studies on selenium metabolism in human T cells. One of the major 75Se-labeled selenoproteins detected was purified to homogeneity and shown to be a homodimer of 55-kDa subunits. Each subunit contained about 1 FAD and at least 0.74 Se. This protein proved to be thioredoxin reductase (TR) on the basis of its catalytic activities, cross-reactivity with anti-rat liver TR antibodies, and sequence identities of several tryptic peptides with the published deduced sequence of human placental TR. Physicochemical characteristics of T-cell TR were similar to those of a selenocysteine (Secys)-containing TR recently isolated from human lung adenocarcinoma cells. The sequence of a 12-residue 75Se-labeled tryptic peptide from T-cell TR was identical with a C-terminal-deduced sequence of human placental TR except that Secys was present in the position corresponding to TGA, previously thought to be the termination codon, and this was followed by Gly-499, the actual C-terminal amino acid. The presence of the unusual conserved Cys-Secys-Gly sequence at the C terminus of TR in addition to the redox active cysteines of the Cys-Val-Asn-Val-Gly-Cys motif in the FAD-binding region may account for the peroxidase activity and the relatively low substrate specificity of mammalian TRs. The finding that T-cell TR is a selenoenzyme that contains Se in a conserved C-terminal region provides another example of the role of selenium in a major antioxidant enzyme system (i.e., thioredoxin-thioredoxin reductase), in addition to the well-known glutathione peroxidase enzyme system.
The α7β0 Isoform of the Complement Regulator C4b-Binding Protein Induces a Semimature, Anti-Inflammatory State in Dendritic Cells (2013)

The classical pathway complement regulator C4b-binding protein (C4BP) is composed of two polypeptides (α- and β-chains), which form three plasma oligomers with different subunit compositions (α7β1, α7β0, and α6β1). We show in this article that the C4BP α7β0 isoform (hereafter called C4BP[β(-)] [C4BP lacking the β-chain]), overexpressed under acute-phase conditions, induces a semimature, tolerogenic state on human monocyte-derived dendritic cells (DCs) activated by a proinflammatory stimulus. C4BP isoforms containing β-chain (α7β1 and α6β1; C4BP[β(+)]) neither interfered with the normal maturation of DCs nor competed with C4BP(β(-)) activity on these cells. Immature DCs (iDCs) treated with C4BP(β(-)) retained high endocytic activity, but, upon LPS treatment, they did not upregulate surface expression of CD83, CD80, and CD86. Transcriptional profiling of these semimature DCs revealed that treatment with C4BP(β(-)) prevented the induction of IDO and BIC-1, whereas TGF-β1 expression was maintained to the level of iDCs. C4BP(β(-))-treated DCs were also unable to release proinflammatory Th1 cytokines (IL-12, TNF-α, IFN-γ, IL-6, IL-8) and, conversely, increased IL-10 secretion. They prevented surface CCR7 overexpression and, accordingly, displayed reduced chemotaxis, being morphologically indistinguishable from iDCs. Moreover, C4BP(β(-))-treated DCs failed to enhance allogeneic T cell proliferation, impairing IFN-γ production in these cells and, conversely, promoting CD4(+)CD127(low/neg)CD25(high)Foxp3(+) T cells. Deletion mutant analysis revealed that the complement control protein-6 domain of the α-chain is necessary for the tolerogenic activity of C4BP(β(-)). Our data demonstrate a novel anti-inflammatory and immunomodulatory function of the complement regulator C4BP, suggesting a relevant role of the acute-phase C4BP(β(-)) isoform in a number of pathophysiological conditions and potential applications in autoimmunity and transplantation.
Acute in vitro production of acylation stimulating protein in differentiated human adipocytes. (1997)

We have previously shown that in normolipidemic healthy adults, plasma acylation stimulating protein (ASP) increases postprandially and is produced in vitro by cultured differentiated human adipocytes. The present studies were undertaken to examine the influence of specific plasma components on endogenous ASP production in cultured human adipocytes. The results demonstrate that neither glucose nor fatty acids (over a wide range of concentrations) had any substantial effect on ASP production. Insulin increased ASP production up to 2-fold (208% +/- 18%, P < 0.01). However, the most profound increase in ASP was generated by the addition of chylomicrons to the cell culture medium. Chylomicrons (CHYLO) obtained from postprandial plasma increased ASP production in a time- and concentration-dependent manner, producing up to a 150-fold increase in ASP at the highest concentration of CHYLO tested (500 microg triacylglycerol/mL medium (P < 0.001)). By contrast, very low (VLDL), high (HDL), and low density lipoproteins (LDI) had only marginal effects. The effects on ASP parallelled the changes in adipocyte C3 secretion (the precursor protein of ASP). As with ASP, glucose, oleate, insulin, and hepatic lipoproteins (VLDL, LDL, and HDL) had little or no effect on C3 secretion. In contrast, CHYLO had an even greater effect on C3 secretion than on ASP generation. Finally, the effects of CHYLO on generation of ASP and C3 were not dependent on lipolysis of CHYLO by lipoprotein lipase (LPL). These results are consistent with the changes in plasma ASP seen postprandially, and suggests a role of ASP as a positive feedback regulator of triacylglycerol synthesis in adipose tissue.
Flue gas desulfurization/Advances in SO/sub 2/ stack gas scrubbing (1978)

A survey shows that none of the emerging sulfur dioxide removal technologies appear to have an overriding cost advantage over present generation conventional boiler/FGD systems. Of the emerging technologies, atmospheric fluidized bed combustion appears the most attractive because it is relatively simple in concept and offers the promise of reasonable annual revenue requirements. Other than a moderate increase in efficiency, there does not seem to be any redeeming advantage to the more complex (and less developed) pressurized fluidized bed systems. Coal liquefaction and gasification coupled with conventional steam generators appears as the most expensive and least attractive control option. Gasification economics, however, are substantially improved when an advanced combined gas/steam cycle is employed.
Plasma chromatography of benzene with mass identified mobility spectra (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPlasma chromatography of benzene with mass identified mobility spectraS. H. Kim, K. R. Betty, and F. W. KarasekCite this: Anal. Chem. 1978, 50, 13, 1784–1788Publication Date (Print):November 1, 1978Publication History Published online1 May 2002Published inissue 1 November 1978https://pubs.acs.org/doi/10.1021/ac50035a018https://doi.org/10.1021/ac50035a018research-articleACS PublicationsRequest reuse permissionsArticle Views95Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
CO-OP: Cooperative Machine Learning from Mobile Devices (2017)

Massive amounts of user behavior logs and sensor data are generated on mobile devices, which can help to improve the usability of social media apps and other intelligent apps. However, collecting such personal data may spark privacy and legal concerns. Recently, many efforts in both academia and industry have been devoted to developing distributed machine learning methods and architectures to scale up to a large amount of distributed data. However, most such methods focus on a server cluster or data residing on several datacenters. This work takes one more step toward the more ambitious objective of collectively training machine learning models based on data from mobile devices, yet without collecting such private data centrally. We propose CO-OP, an asynchronous protocol which leverages the computing power of each mobile client to train local models based on small amounts of newly generated training samples, and merges such local models into a global model on the server judiciously, balancing the model accuracy and communication overhead. We implemented a CO-OP Android app and tested it on 60 real clients distributed in different continents. Results suggest that CO-OP can achieve an accuracy of more than 80% on image classification using neural networks based on the MNIST datasets, even when the clients are intermittently available and training data are generated dynamically on the go. Additional simulation results also demonstrate the effectiveness of CO-OP in training Support Vector Machine (SVM) and Logistic Regression models.
APOBEC3F Can Inhibit the Accumulation of HIV-1 Reverse Transcription Products in the Absence of Hypermutation (2006)

APOBEC3F (apolipoprotein B mRNA-editing enzyme catalytic polypeptide 1-like protein 3F) is a cytidine deaminase that, like APOBEC3G, is able to restrict the replication of HIV-1/delta vif. Initial studies revealed high numbers of mutations in the cDNA of viruses produced in the presence of these proteins, suggesting that cytidine deamination underpinned the inhibition of infection. However, we have recently shown that catalytically inactive APOBEC3G proteins, derived through mutation of the C-terminal cytidine deaminase motif, still exert a substantial antiviral effect. Here, we have generated a panel of APOBEC3F mutant proteins and show that the C-terminal cytidine deaminase motif is essential for catalytic activity and that catalytic activity is not necessary for the antiviral effect of APOBEC3F. Furthermore, we demonstrate that the antiviral activities of wild-type and catalytically inactive APOBEC3F and APOBEC3G proteins correspond well with reductions in the accumulation of viral reverse transcription products. Additional comparisons between APOBEC3F and APOBEC3G suggest that the loss of deaminase activity is more detrimental to APOBEC3G function than to APOBEC3F function, as reflected by perturbations to the suppression of reverse transcript accumulation as well as antiviral activity. Taken together, these data suggest that both APOBEC3F and APOBEC3G are able to function as antiviral factors in the absence of cytidine deamination, that this editing-independent activity is an important aspect of APOBEC protein-mediated antiviral phenotypes, but that APOBEC3F may be a better model in which to study it.
Abacavir and lamivudine combination (2009)

The efficacy of abacavir-lamivudine is well documented in numerous clinical studies and treatment guidelines. The introduction of laboratory testing to identify patients at risk for hypersensitivity has decreased the incidence of these reactions. Recent findings suggest that abacavir is an alternative treatment agent with baseline HIV RNA > 100,000 copies/ml. Data related to cardiovascular events associated with abacavir are conflicting. Hepatic function should be monitored closely in HIV/HBV co-infected patients who discontinue lamivudine-containing products as severe acute exacerbations of HBV have been reported.
A Study of Error-Tolerant Techniques for Speech Underst anding (2000)

In this paper,error tolerant techniques are studied for large vocabulary speaker independent Chinese continuous speech recognition and understanding systems.When N best syllable candidates with their corresponding acoustic scores are generated and a syllable lattice is constructed by the acoustic recognizer,an error tolerant linguistic parser is used to search through the syllable lattice and find the optimal Chinese character sequence in which syllables of some characters may not be included in the lattice because additional possible candidates are considered.In such a way,some acoustic errors are corrected and the robustness of the parser is improved.Our experiments show that the error tolerant parser can increase the understanding rate from 91 83%,a 28 4% error reduction over the conventional trigram model based parser without error tolerant techniques.
Satcom-on-the-move: Digital beam forming versus phased array (2014)

Nowadays, mobile/nomadic satcom terminals are becoming more and more popular, especially for the expanding K/Ka-band services. This paper will give an overview of tradeoffs between the classical phased array RF-frontends where RF-phase shifting devices are used, and digital beam forming topologies where the antenna elements signals are handled at digital level. RF-frontends developed by IMST and partners will serve as illustration of both topologies.
Combinatorial optimization of Ti/Al/Ti/Au ohmic contacts to n‐GaN (2005)

A combinatorial library of Ti/Al/Ti/Au metal contacts to n-type GaN thin films was characterized electrically and microstructurally. Various Ti/Al/Ti/Au thicknesses were deposited by combinatorial ion-beam sputtering (CIBS) on an n-GaN/sapphire substrate followed by rapid-thermal annealing (RTA) at 600 °C to 900 °C in argon for 30 s. The most Al-rich metallization in the library, Ti(20nm)/Al(170nm)/Ti(5nm)/ Au(50nm), was found to have the smoothest surface morphology (rms roughness = 20 nm), while possessing an acceptably low contact resistivity (2.2 × 10–5 Ω cm2) after RTA at 750 °C. XRD analysis of this composition showed that, regardless of RTA temperature, the same two compounds, Al3Ti and Al2Au, were formed in the contact layer. For all other library elements, the interfacial phases in the metal layers were subject to continuous transformations as a function of RTA temperature. We surmise that these temperature-dependent transformations inflicted the excessive surface roughness in the contacts. (© 2005 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)
Human and mouse hair follicles contain both multipotent and monopotent stem cells (2009)

No abstract.
Presence of transforming growth factor alpha and epidermal growth factor in human ovarian tissue and follicular fluid (1998)

Intra-ovarian regulation of follicular maturation is modulated by various factors. Among these, growth factors are important local actors. We examined the immunohistochemical localization of transforming growth factor alpha (TGF-alpha), epidermal growth factor (EGF) and epidermal growth factor receptor (EGF-R) in 18 human ovaries. The concentration of TGF-alpha and EGF in follicular fluid was measured by ELISA. TGF-alpha was detected in oocytes of primordial and early preantral follicles. Furthermore, staining was observed in granulosa cells of preantral follicles and in theca cells of preantral, antral and preovulatory follicles. EGF showed a similar distribution as TGF-alpha. Atretic follicles were strongly positive for TGF-alpha and EGF. In the corpus luteum, theca lutein cells were strongly positive for TGF-alpha and EGF. Immunoreactivity for EGF-R was observed only in the granulosa cells of antral follicles. Follicular fluids from patients undergoing in-vitro fertilization (IVF) were examined for their content of TGF-alpha and EGF. TGF-alpha was detected in 37% of the samples. The concentration ranged from 43 pg/ml to 602 pg/ml. EGF was not detected in any of the follicular fluids tested. These observations support the participation of EGF/TGF-alpha in follicular maturation. Furthermore, the presence of TGF-alpha in follicular fluid and the simultaneous absence of EGF suggests that TGF-alpha plays a more pronounced role than EGF in oocyte maturation during late follicular phase.
ENGLISH CIRCULATING LIBRARIES, 1725–50 (1934)

Journal Article ENGLISH CIRCULATING LIBRARIES, 1725–50 Get access ALAN DUGALD MCKILLOP ALAN DUGALD MCKILLOP Search for other works by this author on: Oxford Academic Google Scholar The Library, Volume s4-XIV, Issue 4, March 1934, Pages 477–485, https://doi.org/10.1093/library/s4-XIV.4.477 Published: 01 March 1934
Fever and cerebral vasospasm in ruptured intracranial aneurysms. (1980)

The temperature curves of 262 patients affected by subarachnoid hemorrhage, including 107 arterial aneurysms, 26 arteriovenous malformations, 42 idiopathic subarachnoid hemorrhages, and 87 cerebral hemorrhages, were observed and classified into three types: Type I: absence of fever; Type II: fever oscillating between 37 degrees and 38 degrees C; and Type III: fever with a plateau between 38 degrees and 39 degrees C beginning on the fifth day at the latest and lasting an average of nine days, with a decline over the next three days. Type III was observed in 3.8% of the patients with arteriovenous malformations, 7% of those with cerebral hemorrhages, and 88.3% of those who had arterial aneurysms with severe angiographic vasospasm associated with delayed ischemic signs. We suggest that the delayed fever is not a simple sign of meningeal syndrome but a sign related to cerebral vasospasm.
Learning to Write (2016)

Learning to write, at the levels of single words and sentences and texts, is an important objective of literacy instruction. Although more research has examined reading development than writing development, experts are gaining an increased knowledge of the development of spelling and composition. Much of the research has examined English, but other languages have been studied too. Research shows that children in literate societies start to learn about characteristics of their writing system before they receive formal schooling. Young children’s early attempts at writing and their responses in other tasks often reveal some knowledge about the appearance of writing. As literacy instruction begins, children’s increasing appreciation of the relation between writing and speech helps facilitate their spelling. In making decisions about how to write words, children use different sources of information, including phonological, morphological, and graphotactic (i.e., information about the arrangement and order of letters). Building on lower-level skills such as spelling and letter production, children develop composing skills and strategies to communicate ideas in writing. Cognitive factors, including memory, constrain the development of composing skill. Research on special populations, such as children with language impairments or hearing loss, has been useful for revealing the processes underlying spelling and writing development and for understanding the challenges that it poses. The research with atypical children, as well as research with typically developing children, can help inform educational practice.
The active earcanal. (1997)

In the past, the human earcanal has primarily been thought of as a passive conduit for sound. Several studies, reported here, explored evidence of how active the earcanal is. The "active earcanal" is conceptualized and aspects of it are viewed through three timeframes: jaw-induced canal change in seconds/minutes, cerumen production in weeks/months, and aging in years. The influence of each of these aspects on hearing aid performance and resulting patient satisfaction is explored. A new self-assessment tool, a Profile of Hearing Aid Physical Fit, is proposed that focuses on measuring patients' perceptions of those benefits that depend on the interface between earcanal and hearing aid.
DETECTION OF "NON-PRECIPITATING" ANTIBODIES IN SERA OF INDIVIDUALS ALLERGIC TO RAGWEED POLLEN BY AN IN VITRO METHOD (1958)

A hemagglutination test capable of demonstrating antibodies in sera of ragweed-sensitive individuals has been described in detail. This test involves coupling of the antigen to rabbit erythrocytes via stable azo bonds. The antigen-coated cells are then suspended in the serum which is suspected to contain the homologous antibodies. The test has been shown to be specific and highly sensitive. Precipitating antibodies to ragweed pollen extract produced in experimental animals can be demonstrated in dilutions as high as 10(5) to 10(7), while antibodies to ragweed in allergic sera are detected only in dilutions of the order of 10(3). Positive results were obtained with all sera from treated or non-treated allergic individuals containing skin-sensitizing and/or blocking antibodies. Absorption of these sera with antigen-coated erythrocytes yielded a supernatant devoid of either skin-sensitizing, blocking, or hemagglutinating capacity. It is concluded that the hemagglutinating factor has the properties of a divalent antibody.
Use of a Rotating Bioreactor toward Tissue Engineering the Temporomandibular Joint Disc (2005)

This objective of this study was to determine the effects of a rotating bioreactor in temporomandibular joint (TMJ) disc tissue engineering. Porcine TMJ disc cells were seeded at a density of 20 million cells/mL onto nonwoven poly(glycolic acid) (PGA) scaffolds in spinner flasks for 1 week and then cultured either under static conditions or in a rotating bioreactor for a period of 6 weeks. A series of analyses was performed, including mechanical testing, measurement of cellularity, quantification of matrix biosynthesis with a hydroxyproline assay and enzyme-linked immunosorbent assays, and observation of matrix distribution with immunohistochemistry. Between the bioreactor and static cultures, there were marked differences in gross appearance, histological structure, and distribution of collagen types I and II. Engineered constructs from the bioreactor contracted earlier and to a greater extent, resulting in a denser matrix and cell composition. In addition, immunostaining intensity was generally uniform in static constructs, in contrast to higher intensity around the periphery of bioreactor constructs. Moreover, bioreactor constructs had higher amounts of collagen II than did static constructs. However, differences in total matrix content and compressive stiffness were generally not significant. On the basis of the results of this study there is no clear benefit from use of the rotating bioreactor, although a sequence of static culture followed by rotating bioreactor culture may prove in the future to be more beneficial than either alone.
Interactive digital television at 42 GHz (1997)

The authors describe and justify the configuration adopted in a large scale real condition trial, of a wireless cellular interactive network at 42 GHz, realised in the frame of an E.U. ACTS program, in the area of Athens.
Point cloud registration based on improved ICP algorithm (2018)

Point clouds have typically applications in environment perception and robot navigation, stereo vision, visual registration, and depth estimation. point cloud registration is one of the important steps in 3-D Point Cloud Processing when combining multiple point clouds to reconstruct a 3-D scene. The iterative closest point (ICP) algorithm is most commonly used when the point cloud data obtained from different perspectives are precisely registrated. The classical iterative closest point (ICP) algorithm converges slowly, In this paper, the voxel lattice is used to re-sample the point cloud data, and the kd tree is used to optimize the calculation of the normal vector. Instead, the method of finding the corresponding point is used to improve the accuracy of the point cloud registration.