gebhart/patrepeval huggingface dataset:
Studies on Polypeptides. XXXVI. The Effect of Pyrazole—Imidazole Replacements on the S-Protein Activating Potency of an S-Peptide Fragment<sup>1-3</sup> (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudies on Polypeptides. XXXVI. The Effect of Pyrazole—Imidazole Replacements on the S-Protein Activating Potency of an S-Peptide Fragment1-3Klaus Hofmann and Hans BohnCite this: J. Am. Chem. Soc. 1966, 88, 24, 5914–5919Publication Date (Print):December 1, 1966Publication History Published online1 May 2002Published inissue 1 December 1966https://pubs.acs.org/doi/10.1021/ja00976a035https://doi.org/10.1021/ja00976a035research-articleACS PublicationsRequest reuse permissionsArticle Views144Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
On the Structure and Electrical Properties of Electroless Ni‐B Films (1975)

An electron microscope study and measurements of electrical resistivity have been performed on electrolessly deposited Ni‐B thin films. In contrast to Ni‐P films, the islands of Ni‐B films show a marked internal structure. Ni‐B films have higher electrical resistivity than equally thick Ni‐P films.
Selective Gold Growth on CdSe Seeded CdS Nanorods (2008)

Gold growth onto CdSe seeded CdS nanorods is studied. Preferential growth of gold onto the position of the CdSe seed is identified. The mechanism of growth is assigned to an electrochemical Ostwald ripening process.
Deep Learning in MR Motion Correction: a Brief Review and a New Motion Simulation Tool (view2Dmotion) (2020)

With the development of deep-learning techniques, the application of deep learning in MR imaging processing seems to be growing. Accordingly, deep learning has also been introduced in motion correction and seemed to work as well as do conventional motion-compensation methods. In this article, we review the motion-correction methods based on deep learning, focusing especially on the motion-simulation methods adopted. We then propose a new motion-simulation tool, which we call view2Dmotion.
Two-Dimensional Quantization Effect on Indirect Tunneling in an Insulated-Gate Lateral pn-Junction Structure with a Thin Silicon Layer (2000)

In this paper, the multi-negative conductance property detected at low temperatures in a silicon-on-insulator insulated-gate pn-junction device with a 10-nm-thick silicon layer is described. Important aspects of lateral low-dimensional tunneling process are examined by a theoretical formulation. A comparison of the characteristics of devices with a 10-nm-thick or a 90-nm-thick silicon layer indicates that the strong two-dimensional confinement effect plays an important role in multi-negative conductance. The theory predicts that a “resonance effect” between two subband levels results in the multi-negative conductance in the device with the 10-nm-thick silicon layer.
Random clock against differential power analysis (2010)

Cryptographic systems are being compromised by power analysis attacks. In this paper, a novel countermeasure technique against power analysis attacks is proposed which dynamically varies the clock when executing operations (making it difficult to correlate power traces in the time domain) and inserts dummy operations during idling clock cycles (reducing the signal-to-noise ratio of the useful information). Its effectiveness is shown by performing a DPA attack on basic, intermediate (random clock) and advanced (random clock and dummy data) designs for the AES encryption algorithm, implemented on a FPGA-based board. The intermediate design is resistant to classical DPA attacks and the advanced design reduces the SNR by 79% (increasing area by 70% and reducing performance by 5.33%) when compared to the basic design. It is shown that the design is better in both metrics than other countermeasure techniques.
Isolation and mapping of a polymorphic DNA sequence (CJ52.96) on chromosome 16 [D16S157] (1989)

Cosmid CJ52.96 was isolated from a library constructed from a mouse/human somatic cell hybrid that contains a chromosomellq-16q derivative as the only human chromosome (1). The Sau3A partial digest was inserted into pWe vector.
Iris Segmentation Using Geodesic Active Contours (2009)

The richness and apparent stability of the iris texture make it a robust biometric trait for personal authentication. The performance of an automated iris recognition system is affected by the accuracy of the segmentation process used to localize the iris structure. Most segmentation models in the literature assume that the pupillary, limbic, and eyelid boundaries are circular or elliptical in shape. Hence, they focus on determining model parameters that best fit these hypotheses. However, it is difficult to segment iris images acquired under nonideal conditions using such conic models. In this paper, we describe a novel iris segmentation scheme employing geodesic active contours (GACs) to extract the iris from the surrounding structures. Since active contours can 1) assume any shape and 2) segment multiple objects simultaneously, they mitigate some of the concerns associated with traditional iris segmentation models. The proposed scheme elicits the iris texture in an iterative fashion and is guided by both local and global properties of the image. The matching accuracy of an iris recognition system is observed to improve upon application of the proposed segmentation algorithm. Experimental results on the CASIA v3.0 and WVU nonideal iris databases indicate the efficacy of the proposed technique.
The substrate specificity of Saccharomyces cerevisiae myristoyl-CoA: protein N-myristoyltransferase. Polar probes of the enzyme's myristoyl-CoA recognition site. (1994)

Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase (Nmt1p) is a monomeric enzyme that is essential for vegetative growth. Nmt1p catalyzes the co-translational transfer of myristate from CoA to the amino-terminal Gly of cellular proteins in an ordered Bi Bi reaction mechanism that initially involves binding of myristoyl-CoA to the apoenzyme. Forty one fatty acid analogs were synthesized to define features in the acyl chain of myristoyl-CoA which are important determinants of its recognition by Nmt1p's acyl-CoA binding site as well as to help us deduce the structure of the binding site itself. These analogs included dicarboxylic acids, omega-nitrocarboxylic acids, analogs equivalent in length to C13:0-C15:0 which contain electronegative halogens at their omega-termini, hydroxytetradecanoic acids with hydrogen replaced by OH from C3 to C13, and azidophenyl-containing fatty acids with the linear azide unit attached either meta or para to phenyl and with variations in the length of their methylene chains. These compounds were converted to their CoA derivatives using Pseudomonas acyl-CoA synthetase and then surveyed as substrates for purified Nmt1p in an in vitro assay system that included an octapeptide derived from residues 1-8 of the human immunodeficiency virus Pr55gag polyprotein precursor. The results suggest that the myristoyl-CoA binding site contains a conical-shaped "receptor" that interacts with the omega-terminus of the bound acyl chain of acyl-CoAs. The acuteness of this cone determines the enzyme's capacity to accommodate steric bulk at the omega-terminus as well as Nmt1p's sensitivity to the distance between the eclipsed C5-C6 bond of a bound acyl chain and its omega-terminus. The activity profile of the various analog-CoAs also indicates that the enzyme's myristoyl-CoA binding site can accommodate fatty acid analogs with marked increases in polarity at their omega-terminus (compared to C14:0) as long as their chain length is equivalent to that of myristate.
Mechanistic Insights into a Supramolecular Self‐Assembling Catalyst System: Evidence for Hydrogen Bonding during Rhodium‐Catalyzed Hydroformylation (2012)

Die strukturelle Integrität und Flexibilität, die aus intermolekularen Wasserstoffbrücken resultiert, führt zu den herausragenden Eigenschaften des 6-Diphenylphosphinopyridin-(2H)-1-on-Liganden (siehe Bild) in der Rhodium-katalysierten Hydroformylierung endständiger Alkene. Dies wurde durch eine Kombination aus spektroskopischen Methoden und DFT-Rechnungen nachgewiesen. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Generation of 10 GHz similariton pulse trains from 1.2 km-long erbium-doped fibre amplifier for application to multi-wavelength pulse sources (2004)

A 10 GHz similariton pulse train is generated from a 1.2 km-long erbium-doped fibre amplifier and applied to a multi-wavelength pulse source. Slicing the spectrum of the similariton pulse train, a 10 Gbit/s transmitter was constructed, which has excellent Q-factors of over 25.3 dB in the entire bandwidth. Such uniform characteristics of the sliced pulse train originate from the high spectral flatness of the similariton.
Self-Immolative Thiocarbamates Provide Access to Triggered H<sub>2</sub>S Donors and Analyte Replacement Fluorescent Probes (2016)

Hydrogen sulfide (H2S) is an important biological signaling molecule, and chemical tools for H2S delivery and detection have emerged as important investigative methods. Key challenges in these fields include developing donors that are triggered to release H2S in response to stimuli and developing probes that do not irreversibly consume H2S. Here we report a new strategy for H2S donation based on self-immolation of benzyl thiocarbamates to release carbonyl sulfide, which is rapidly converted to H2S by carbonic anhydrase. We leverage this chemistry to develop easily modifiable donors that can be triggered to release H2S. We also demonstrate that this approach can be coupled with common H2S-sensing motifs to generate scaffolds which, upon reaction with H2S, generate a fluorescence response and also release caged H2S, thus addressing challenges of analyte homeostasis in reaction-based probes.
CBase: A New Paradigm for Fast Virtual Machine Migration across Data Centers (2017)

Live Virtual Machine (VM) migration offers a couple of benefits to cloud providers and users, but it is limited within a data center. With the development of cloud computing and the cooperation between data centers, live VM migration is also desired across data centers. Based on a detailed analysis of VM deployment models and the nature of VM image data, we design and implement a new migration framework called CBase. The key concept of CBase is a newly introduced central base image repository for reliable and efficient data sharing between VMs and data centers. With this central base image repository, live VM migration and further performance optimizations are made possible. The results from an extensive experiment show that CBase is able to support VM migration efficiently, outperforming existing solutions in terms of total migration time and network traffic.
A Neuromorphic aVLSI network chip with configurable plastic synapses (2007)

We describe and demonstrate the key features of a neu- romorphic, analog VLSI chip (termed F-LANN) hosting 128 integrate-and-fire (IF) neurons with spike-frequency adap- tation, and 16 384 plastic bistable synapses implementing a self-regulated form of Hebbian, spike-driven, stochastic plasticity. We were successfully able to test and verify the basic operation of the chip as well as its main new fea- ture, namely the synaptic configurability. This configura- bility enables us to configure each individual synapse as either excitatory or inhibitory and to receive either recur- rent input from an on-chip neuron or AER (Address Event Representation)-based input from an off-chip neuron. It's also possible to set the initial state of each synapse as po- tentiated or depressed, and the state of each synapse can be read and stored on a computer. The main aim of this chip is to be able to efficiently perform associative learning ex- periments on a large number of synapses. In the future we would like to connect up multiple F-LANN chips together to be able to perform associative learning of natural stimulus sets.
Device cloud platform with script based agents for &#x201C;anywhere access&#x201D; applications development (2014)

Providing access to devices via Internet is a growing trend allowing consumers to monitor and control their home appliances, heating, air conditioning and multimedia devices remotely from their tablets or laptops. Increasing number of “anywhere access” applications emerged to provide the users with cutting edge monitoring and control possibilities, including scheduling, event linking or even in-depth behavior scenarios definition. In this paper a device cloud platform architecture and a pilot implementation is presented. The device cloud allows arbitrary web, mobile or PC applications to connect to devices over the internet, to monitor and control their behavior and upgrade their firmware. It is also allowed to compose scripts and define cross-device and cross-event scenarios, which are maintained and executed within the cloud, thus allowing unprecedented level of automation and intelligent control. Main contributions of the presented device cloud are the interoperability with devices based on open technologies (TR-069), dynamic adaptation to device types, dynamic API layer towards user applications, intelligent bandwidth preservation and modular and scalable in-cloud scripting engine.
DISPERSITY AND STABILITY MEASUREMENT OF FUNCTIONALIZED MULTIWALLED CARBON NANOTUBES IN ALCOHOLS (2008)

Multiwalled carbon nanotubes (MWCNTs) were dispersed in various alcohols such as methanol, ethanol and isopropanol using ultrasonication. In order to disperse the MWCNTs in the alcohols, they were treated using a mixture of H 2 SO 4 and HNO 3 (3 : 1, vol/vol). The concentration of MWCNTs was approximately 0.03 wt.% and they formed a homogeneous dispersion in the alcohol solutions. The functional groups introduced on the surface of the MWCNTs during the acid treatment were characterized by Fourier transform-infrared spectroscopy and X-ray photoelectron spectroscopy. The dispersibility of the MWCNTs in the alcohols was characterized using atomic force microscopy, scanning electron microscopy and transmission electron microscopy. The stability of the MWCNT dispersions was also measured using a recently developed optical analyzer (Turbiscan).
Requirement of the Human GARP Complex for Mannose 6-phosphate-receptor-dependent Sorting of Cathepsin D to Lysosomes (2008)

The biosynthetic sorting of acid hydrolases to lysosomes relies on transmembrane, mannose 6-phosphate receptors (MPRs) that cycle between the TGN and endosomes. Herein we report that maintenance of this cycling requires the function of the mammalian Golgi-associated retrograde protein (GARP) complex. Depletion of any of the three GARP subunits, Vps52, Vps53, or Vps54, by RNAi impairs sorting of the precursor of the acid hydrolase, cathepsin D, to lysosomes and leads to its secretion into the culture medium. As a consequence, lysosomes become swollen, likely due to a buildup of undegraded materials. Missorting of cathepsin D in GARP-depleted cells results from accumulation of recycling MPRs in a population of light, small vesicles downstream of endosomes. These vesicles might correspond to intermediates in retrograde transport from endosomes to the TGN. Depletion of GARP subunits also blocks the retrograde transport of the TGN protein, TGN46, and the B subunit of Shiga toxin. These observations indicate that the mammalian GARP complex plays a general role in the delivery of retrograde cargo into the TGN. We also report that a Vps54 mutant protein in the Wobbler mouse strain is active in retrograde transport, thus explaining the viability of these mutant mice.
Pharmacokinetics, tissue distribution, and cell localization of [35S]methionine-labeled recombinant human and murine alpha interferons in mice. (1990)

The pharmacokinetics, tissue distribution, cell localization, and penetration into tumor xenografts of recombinant [35S]methionine-labeled human alpha interferon (HuIFN-alpha) and murine alpha interferon (MuIFN-alpha) were examined in mice. Both interferons (IFNs) were removed from the blood in a rapid biphasic manner; HuIFN-alpha was cleared faster than MuIFN-alpha. Tissues were analyzed for radioactivity and over 90% of the IFNs was accounted for. The IFNs were detected predominantly in liver, kidney, gastrointestinal tract, pancreas, spleen, and lung. The levels of MuIFN-alpha compared with HuIFN-alpha were greater in the liver, spleen, and lung and less in the kidney, pancreas, and gastrointestinal tract. Heart, brain, testes, thymus, lymph nodes, fat, skin, and skeletal muscle contained much lower but measurable levels of both IFNs. There was penetration of HuIFN-alpha into tumor xenografts. The pharmacokinetics of IFN-alpha were independent of the strain of mouse, BALB/c or CBA, immune deprivation, or the presence of a tumor xenograft. Autoradiography of tissue sections from mice given injections of HuIFN-alpha or MuIFN-alpha indicated focal radioactivity in proximal convoluted tubules in the kidney and diffuse radioactivity in the liver, gastrointestinal tract, and pancrease. MuIFN-alpha, but not HuIFN-alpha, showed intense localization in cells in hepatic sinusoids, marginal zones in the spleen, and pulmonary alveolar walls, suggesting uptake by cells of the monocyte/macrophage lineage in these sites. The study shows the utility of biosynthetic labeling for pharmacokinetic studies of cytokines, clear differences in tissue distribution of IFN-alpha according to its species of origin, and targeting of homologous IFN-alpha to cells of the monocytic lineage.
The Role of Chemokines in Wound Healing (2018)

Wound healing is a multistep process with four overlapping but distinct stages: hemostasis, inflammation, proliferation, and remodeling. An alteration at any stage may lead to the development of chronic non-healing wounds or excessive scar formation. Impaired wound healing presents a significant health and economic burden to millions of individuals worldwide, with diabetes mellitus and aging being major risk factors. Ongoing understanding of the mechanisms that underly wound healing is required for the development of new and improved therapies that increase repair. Chemokines are key regulators of the wound healing process. They are involved in the promotion and inhibition of angiogenesis and the recruitment of inflammatory cells, which release growth factors and cytokines to facilitate the wound healing process. Preclinical research studies in mice show that the administration of CCL2, CCL21, CXCL12, and a CXCR4 antagonist as well as broad-spectrum inhibition of the CC-chemokine class improve the wound healing process. The focus of this review is to highlight the contributions of chemokines during each stage of wound healing and to discuss the related molecular pathologies in complex and chronic non-healing wounds. We explore the therapeutic potential of targeting chemokines as a novel approach to overcome the debilitating effects of impaired wound healing.
Modified sling snoreplasty: double triangle shaped suture uvulopalatopexy. (2010)

Following the uvulopalatopharyngoplasty and laser assisted uvulopalatoplasty as treatments for mild obstructive sleep apnea syndrome (OSAS) originating from the soft palate, palatal stiffening operations began to be described as causing less morbidity, interfering less with velopharyngeal and mucosal functions, and being applicable in outpatient settings. We present modified uvulopalatopexy procedure which can be used in mild OSAS patients is a simple, minimally invasive and effective new method. In this article, we present a modified form of sling snoreplasty method and two cases in whom this method was used.
Intravenous immunoglobulins in systemic lupus erythematosus: from the bench to the bedside (2009)

This article is an update on the clinical and research data available on systemic lupus erythematosus (SLE) and intravenous immunoglobulin (IVIg) therapy that includes some studies performed under the umbrella of the European Working Party on SLE. Various mechanisms of IVIg may play a role, some synergistically, in the modulation of SLE. Recently it has been suggested that IVIg also suppresses the expansion of autoreactive B lymphocytes through signalling of the FcgRIIB, idiotype-mediated inhibition of B cell receptors and neutralisation of cytokines such as the B cell survival factors (B cell activation factor (BAFF and APRIL). In case reports and in open trials, high-dose IVIg (2 g/kg over a 5-day period) has consistently been shown to be a beneficial and safe adjunct therapeutic agent for over 20 manifestations in patients with SLE. It can be given as a first choice of therapy in some cases, for example, in neurological involvement and in those patients who refuse certain immunosuppressive agents such as cyclophosphamide, or in patients who have concomitant infections. Furthermore, IVIg may have a steroid-sparing effect although this characteristic needs further investigation. Specific IVIg (an anti-idiotype to anti-DNA, phosphorylcholine and antiphospholipids) has been shown to be effective in experimental murine models. Hence, extractable IVIg that is directed to the specific pathogenic immunoglobulins will enable the more specific therapy for patients with lupus.
Quantification and Minimization of Magnetic Susceptibility Artifacts on GRE Images (2000)

Radiologists can easily adjust the above parameters in their imaging protocols to improve GRE image quality in patients with implanted metallic devices.
Advances in two photon scanning and scanless microscopy technologies for functional neural circuit imaging (2016)

Abstract Recent years have seen substantial developments in technology for imaging neural circuits, raising the prospect of large scale imaging studies of neural populations involved in information processing, with the potential to lead to step changes in our understanding of brain function and dysfunction. In this article we will review some key recent advances: improved fluorophores for single cell resolution functional neuroimaging using a two photon microscope; improved approaches to the problem of scanning active circuits; and the prospect of scanless microscopes which overcome some of the bandwidth limitations of current imaging techniques. These advances in technology for experimental neuroscience have in themselves led to technical challenges, such as the need for the development of novel signal processing and data analysis tools in order to make the most of the new experimental tools. We review recent work in some active topics, such as region of interest segmentation algorithms capable of demixing overlapping signals, and new highly accurate algorithms for calcium transient detection. These advances motivate the development of new data analysis tools capable of dealing with spatial or spatiotem-poral patterns of neural activity, that scale well with pattern size.