gebhart/patrepeval huggingface dataset:
Heymann nephritis in rats induced by human renal tubular antigens: characterization of antigen and antibody specificities. (1987)

An injection of human renal tubular fraction, Fx1A, with Freund's complete adjuvant in rats induces Heymann nephritis (HN) with clinical and morphological features similar to rat Fx1A-induced HN. The present study was undertaken to characterize antibody specificities and the corresponding antigen involved in human Fx1A-induced HN. In sera of rats immunized with human Fx1A, not only anti-human Fx1A antibody but also antirat Fx1A antibody was detected by enzyme immunoassay. Eluted antibody from the glomeruli also showed both activities. In an inhibition study of enzyme immunoassay, binding of the eluted antibody to human Fx1A was inhibited by both human and rat Fx1A and also by partially purified gp330, but not by purified gp108. Furthermore, binding of the eluted antibody to rat Fx1A was inhibited by both rat and human Fx1A. On immunoblot, the eluted antibody mainly reacted with a 440 kD glycoprotein of human Fx1A which showed the same mobility as rat gp330. The antibody also reacted with a band of gp330 of rat Fx1A. These results indicate that the 440 kD glycoprotein in humans is a counterpart of rat gp330 and that the eluted antibody has dual specificities to both human 440 kD glycoprotein and rat gp330, suggesting that the cross-reactive antibody is responsible for human Fx1A-induced HN.
Phase II study of lapatinib, a dual inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase 1 and 2 (Her2/Neu) in patients (pts) with advanced biliary tree cancer (BTC) or hepatocellular cancer (HCC). A California Consortium (CCC-P) Trial (2006)

4010 Background: Advanced BTC (gallbladder, bile duct) and HCC respond poorly to systemic chemotherapy. Lapatinib is an oral inhibitor of EGFR and Her/2-neu with evidence of activity in a number of tumor types. Both BTC and HCC overexpress EGFR 1 and 2. In addition, Her2/neu somatic mutations have been reported in HCC, and may predict response to EGFR targeted agents (Bekaii-Saab et al, A 4037, ASCO 2005). This trial conducted by the CCC-P and Univ. Chicago, is designed to determine the efficacy of lapatinib in BTC and HCC pts. Methods: A two-stage design is utilized and pts are stratified by tumor type (BTC or HCC); the study has a 90% power to detect a true response rate ≥20%. Two initial groups of 17 patients for BTC and HCC were accrued; one response from each was required to proceed with accrual to a total of 37 patients in each group. Adequate hematologic, renal, and hepatic function is required. Eligible pts are in Child A group and have ECOG PS of 0–2. One prior treatment regimen is allowed. Lapatinib dose is 1,500 mg/d orally without interruption. One cycle is 28 days and radiological assessment is done every 8 weeks. Results: 49 pts have been accrued (BTC 19 and HCC 30). Pt Characteristics: Male 59%, ECOG PS 0 (18 pts), ECOG PS 1 (22 pts). Median age 66 yrs (range19–82). Median cycles 2 (range 1–12). Grade 3/4 toxicity was noted in 19 pts and included fatigue in 4 pts, elevation of liver enzymes in 4 pts and diarrhea in 2 pts. Nausea, vomiting, rash, anemia and thrombocytopenia were noted in 1 pt each. There was no evidence of cardiac dysfunction. In 17 evaulable pts with BTC, no responses were observed, 5 had stable disease (SD). Among the first 17 pts with HCC, 2 confirmed partial responses have been recorded. In addition 8 pts have SD. The progression free survival is 1.8 mo for both BTC and HCC. Tumor and blood specimens are being analyzed for expression of EGFR, HER-2/neu, status of downstream signal pathway molecules, and correlation to response. Conclusions: Lapatinib is well-tolerated. No activity in BTC was noted and that cohort is closed. Lapatinib activity in HCC is encouraging, and study is close to completion. Source of support: NCI-NO1-CM-57018–16. [Table: see text]
Synthesis of functionalized linear poly(divinylbenzene). II. Synthesis of poly(divinylbenzene) with hydroxyl pendants and/or endgroups (1984)

Abstract Poly(divinylbenzene) [poly(DVB)] derivatives having hydroxyl terminals and/or pendants were synthesized by chemical modifications (hydration and hydroxylation) of unsaturated linear poly(DVB) ( I ), which was prepared by the polymerization of DVB catalyzed by acetyl perchlorate. Hydroboration of both terminal and in‐chain carbon–carbon double bonds in I with BH 3 .THF complex yielded a fully hydrated poly(DVB) II , in which hydrophilic and hydrophobic groups are placed alternately. Selective hydroboration of the vinyl endgroups in I with 9‐borabicyclo[3.3.1]nonane led to an α,ω‐dihydroxy‐poly(DVB) ( III ). Reaction of I with m ‐chloroperbenzoic acid gave fully epoxidated poly(DVB) IV , which was subsequently hydrated to yield polymer V consisting of glycol repeat units and terminals. The physical properties and reactions (chain extension and crosslinking) of these polymers were also studied.
FEASIBLE (I): The PC software package for Feature Evaluation and System Inspection by Logged Experiments (1988)

FEASIBLE is an MS-DOS software package which can be used for the evaluation of: Picture Archiving and Communication System (PACS) components; diagnostic image quality; and image manipulation and representation techniques. The FEASIBLE software allows the user to design any psychophysical study in detail in the fields mentioned above, to execute an arbitrary number of sessions and to statistically analyse the results by way of the Receiver Operating Characteristic (ROC) technique. FEASIBLE consists basically of three modules: DESIGN, which allows the user to set up an experiment; EXECUTION, which allows the user to execute the experimental sessions based on the design entered in the DESIGN module and stored in the program's database; and, STATISTICS, which allows various statistical analyses on the data collected during the psychophysical sessions (including the calculation of ROC curves and related parameters) and can provide a graphical presentation of the results. FEASIBLE has been designed to support experts and those who have little knowledge of psychophysical experiments. This paper discusses the background, structure and possibilities of the FEASIBLE package at this point (version 1.2, May 1988).
Notes on <i>Paliolla Cooki</i> (Angas, 1894) from Southern Australia <i>(Opisthobranchia: Gymnodorididae)</i> (1975)

Summary Paliolla cookl (Angas. 1864) is a specialized gymnodorldid opisthobranch with 9–10 needle-like radulor teeth. each arising from Its own socket In the pharynx and up to 1.4 mm in length. It apparently uses the teeth to pierce the skin of Its food. and sucks In the body fluids by means of buccal pump modifications of the pharyngeal wall. It is found from central New South Wales. through Victoria to St Vincent Gulf, South Australia, from low tide to 55 m.
Neoplastic transformation of epithelial cells in whole mammary gland in vitro. (1979)

Biological characteristics of nodule-like alveolar lesions (NLAL) induced by 7,12-dimethylbenz[a]anthracene (DMBA) in organ culture of whole mammary gland (BALB/c female mice) were assessed after transplantation into gland-free mammary fat pads of syngeneic virgin mice. (i) Tissue-fragment explants from NLAL areas of the gland produced abnormal lobuloalveolar (LA) outgrowths in 3 of 10 fat pads. (ii) Transplantation of dissociated cells of NLAL-derived LA outgrowths into 36 fat pads showed 100% LA outgrowths and 3 (8%) of these 36 outgrowths produced mammary carcinomas. (iii) The explants of dissociated cells from whole mammary glands treated with DMBA in culture produced full or partial LA structures in 2 of 56 outgrowths. (iv) The explants of dissociated cells prepared from outgrowths derived from outgrowths derived from explants as in iii produced 9 LA outgrowths in 16 instances; mammary tumor incidence in these outgrowths was 3 of 16 (18%). (v) The explants of tissue fragments from LA outgrowths as in iv produced LA outgrowths in 20 of 20 fat pads; mammary carcinomas appeared in 16 of 20 (80%) of these outgrowths. No NLAL was detectable in control glands treated with dimethyl sulfoxide (solvent for DMBA); explants of the control glands consistently produced ductal outgrowths and no tumor. This accomplishment of chemical carcinogen-induced neoplastic transformation of epithelial cells in vitro provides a model for studying carcinogenesis in an entire isolated organ.
A Phase II study of paclitaxel in patients with recurrent malignant glioma using different doses depending upon the concomitant use of anticonvulsants (2001)

Even though higher doses were administered to patients who had recurrent malignant glioma and who were on concomitant anticonvulsants, there were no objective responses to paclitaxel. Time to tumor progression was 1 month. Further testing of paclitaxel at this dose schedule does not appear to be warranted in this patient population.
Synthesis of oligoesters and polyesters from oxalic acid and ethylene glycol (1977)

Abstract High molecular weight poly(ethylene oxalate) with fiber‐forming properties was obtained from oxalic acid and ethylene glycol. The process was carried out on two stages in the melt. A new method was used for aliphatic oligoester synthesis in the melt, because the decomposition of oxalic acid takes place in the presence of glycol. The process was carried out at low temperatures with azeotropic water removal. Investigations of the polycondensation of oxalic acid and ethylene glycol with a compound forming a heteroazeotrope with water showed that the process is subject to the general laws of the polycondensation in melt: it depends on the ratio of initial components, presence of accelerating compounds, etc. However, the reaction time of polycondensation was dependent on the stirring intensity. High molecular weight poly(ethylene oxalate) was obtained by oligomer polycondensation in the melt. Thorium carbonate and tin dichloride were used as catalysts.
Observation of Excited-State Proton Transfer in Green Fluorescent Protein using Ultrafast Vibrational Spectroscopy (2005)

The photodynamics of wtGFP have been studied by ultrafast time-resolved infrared spectroscopy (TIR). In addition to the expected bleaching and transient infrared absorption of bands associated with the chromophore, we observe the dynamics of the proton relay reaction in the protein. Protonation of a protein carboxylate group occurs on the tens of picoseconds time scale following photoexcitation. Comparison with data for mutant GFPs, in which excited-state proton transfer has been disabled, supports the assignment of the carboxylate to the side chain of E222, a component of the hydrogen bonding network that links the two ends of the chromophore. The TIR data show that the rate-limiting step in the proton relay is deprotonation of the chromophore.
Integration von Kunden- und Mitarbeiterorientierung (1999)

Das klassische Marketing orientierte sich in der Vergangenheit primär am Absatzmarkt. Die damit einhergehende Dominanz der horizontalen Betrachtung des Marktgeschehens wurde zunächst durch das Vertikale bzw. das Trade Marketing korrigiert. Dadurch rückten anfangs die nachgelagerten und später die vorgelagerten Stufen des Marktgeschehens in den Focus der Betrachtung; als Folge der sog. Ölkrise entwickelte sich etwa das Beschaffungsmanagement zu einer eigenständigen Disziplin (Arnold 1995).
Spectral Affine‐Kernel Embeddings (2017)

Abstract In this paper, we propose a controllable embedding method for high‐ and low‐dimensional geometry processing through sparse matrix eigenanalysis. Our approach is equally suitable to perform non‐linear dimensionality reduction on big data, or to offer non‐linear shape editing of 3D meshes and pointsets. At the core of our approach is the construction of a multi‐Laplacian quadratic form that is assembled from local operators whose kernels only contain locally‐affine functions. Minimizing this quadratic form provides an embedding that best preserves all relative coordinates of points within their local neighborhoods. We demonstrate the improvements that our approach brings over existing nonlinear dimensionality reduction methods on a number of datasets, and formulate the first eigen‐based as‐rigid‐as‐possible shape deformation technique by applying our affine‐kernel embedding approach to 3D data augmented with user‐imposed constraints on select vertices.
Redox regulation of Brn-2/N-Oct-3 POU domain DNA binding activity and proteolytic formation of N-Oct-5 during melanoma cell nuclear extraction (1998)

Reversible oxidation sensitivity of N-Oct-3 DNA binding activity was seen when melanoma extracts and recombinant Brn-2 protein were treated with a variety of metals, hydrogen peroxide and the cysteine disulphide bond forming agent diamide. Western blot analysis of diamide-oxidized N-Oct-3 protein indicated that this was likely to be due to intramolecular disulphide bonding. The potential role of oxidative loss of N-Oct-3 DNA binding activity is discussed in relation to redox changes that may occur during the early phase of apoptosis in neuronal cell lines and tissues. Brn-2 C-terminal antibody Western blot analysis of melanoma cell line nuclear extracts prepared using a combination of sodium dodecyl sulphate and NP-40 detergent cell lysis procedures demonstrated the formation of N-Oct-5 DNA binding activity via N-terminal proteolytic clipping of Brn-2/N-Oct-3.
<scp>PEPCOL</scp>: a <scp>GERCOR</scp> randomized phase <scp>II</scp> study of nanoliposomal irinotecan <scp>PEP</scp>02 (<scp>MM</scp>‐398) or irinotecan with leucovorin/5‐fluorouracil as second‐line therapy in metastatic colorectal cancer (2016)

A multicenter, open-label, noncomparative, randomized phase II study (PEPCOL) was conducted to evaluate the efficacy and safety of the irinotecan or PEP02 (MM-398, nanoliposomal irinotecan) with leucovorin (LV)/5-fluorouracil (5-FU) combination as second-line treatment in patients with metastatic colorectal cancer (mCRC). Patients with unresectable mCRC who had failed one prior oxaliplatin-based first-line therapy were randomized toirinotecan with LV/5-FU (FOLFIRI) or PEP02 with LV/5-FU (FUPEP; PEP02 80 mg/m(2) with LV 400 mg/m(2) on day 1 and 5-FU 2400 mg/m(2) on days 1-2). Bevacizumab (5 mg/kg, biweekly) was allowed in both arms. The primary endpoint was 2-month response rate (RR). Fifty-five patients were randomized (FOLFIRI, n = 27; FUPEP, n = 28). In the intent-to-treat population (n = 55), 2-month RR response rate was observed in two (7.4%) and three (10.7%) patients in the FOLFIRI and FUPEP arms, respectively. The most common grade 3-4 adverse events reported in the respective FOLFIRI and FUPEP arms were diarrhea (33% vs. 21%), neutropenia (30% vs. 11%), mucositis (11% vs. 11%), and grade 2 alopecia (26% vs. 25%). FUPEP has activity and acceptable safety profile in oxaliplatin-pretreated mCRC patients.
New Method for Generation of Thiocarbonyl Ylides from Bis(trimethylsilylmethyl)sulfoxides and Their Application to Cycloadditions (1995)

Absnac-Thiocarbonyl ylides were generated by heating of bis(trimethy1silylmethyl) sulfoxides.Cycloadditions of the ylides in the presence of dipolarophiles proceeded smoothly to give di-or teuahydrothiophenes.A thiocarbonyl ylide is conveniently represented by the structure (la), which includes 1,3-dipolar structure (1 b) as a resonance form, and it is a useful reactive intermediate for synthesis of heterocycles containing a sulfur atom.'Representative method for generation of thiocarbonyl ylides was reported by Kellogg2 and Huisgen.'They prepared the ylides by thermal decomposition of thiadiazolidines which were prepared from thioketones and diazoalkanes.Recently we reported a facile generation of silylthioaldehyde S-methylide by thermal desilylbromide of bromo(trjmetbylsilyl)methyl mmethylsilylmethyl sulfide and its derivatives.'After further investigation in order to overcome some limitations for this method, we have found a new method for generation of thiocarbonyl ylide from bis(mmethylsilylmethyl) sulfoxides and their 1.3-dipolar cycloadditions leading to dior teuahydrothiophenes.In this paper, details of these new methods are described.'Our strategy for the generation of thiocarbonyl ylide involves the release of disiloxane from bis(trimethylsilylmethyl) sufoxide (2a) through a pathway related to the sila-Pummerer rearrangement (Scheme
Percent infarct mapping for delayed contrast enhancement magnetic resonance imaging to quantify myocardial viability by Gd(DTPA) (2010)

We have shown here, ex vivo, that SI-PIM has the same advantages as R1-PIM, but it is based on the scanning sequences of DE imaging, and thus it is obtainable within the same short scanning time as DE. This makes it a practical method for clinical studies.
Formation of p+ shallow junctions using SiGe barriers (2004)

Ultrashallow p+ junctions are required for next generation electronics. We present a technique for the formation of ultrashallow p+ junctions that increases the thermal stability of the junctions formed by either epitaxy or ion implantation. By using a 10nm Si1−xGex barrier layer, the diffusion of B is inhibited during high temperature processes. Alloys having a composition from x=0–0.4 were investigated and it is shown that the most effective barrier had the maximum Ge fraction. The junction depth decreased to 36.7nm for a 5×1015∕cm2 1kV BF3 plasma implant spike annealed at 1050°C, compared to a junction depth of 48nm for a Si control sample having the identical implant and anneal. It is hypothesized that the inhibition of B diffusion in the alloy layer is caused by a reduction of the Si self-interstitials in the alloy.
Social interactions in multiscale CVEs (2002)

A multiscale Collaborative Virtual Environment (mCVE) is a virtual world in which multiple users can independently resize themselves to work together on different sized aspects of very large and complicated structures. Interactions among users in an mCVE differ in many ways from those in traditional collaborative virtual environments. In this paper we explore collaboration-related issues affected by multiscale, such as social presence, perception of proximity, and cross-scale information sharing. We also report results of an experiment with our mCVE prototype system, which show the impact of multiscale capabilities on social interactions.
Oxidatively Modified Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) and Alzheimer's Disease: Many Pathways to Neurodegeneration (2010)

Recently, the oxidoreductase, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), has become a subject of interest as more and more studies reveal a surfeit of diverse GAPDH functions, extending beyond traditional aerobic metabolism of glucose. As a result of multiple isoforms and cellular locales, GAPDH is able to come in contact with a variety of small molecules, proteins, membranes, etc., that play important roles in normal and pathologic cell function. Specifically, GAPDH has been shown to interact with neurodegenerative disease-associated proteins, including the amyloid-beta protein precursor (AbetaPP). Studies from our laboratory have shown significant inhibition of GAPDH dehydrogenase activity in Alzheimer's disease (AD) brain due to oxidative modification. Although oxidative stress and damage is a common phenomenon in the AD brain, it would seem that inhibition of glycolytic enzyme activity is merely one avenue in which AD pathology affects neuronal cell development and survival, as oxidative modification can also impart a toxic gain-of-function to many proteins, including GAPDH. In this review, we examine the many functions of GAPDH with respect to AD brain; in particular, the apparent role(s) of GAPDH in AD-related apoptotic cell death is emphasized.
Viremia Control Despite Escape from a Rapid and Potent Autologous Neutralizing Antibody Response After Therapy Cessation in an HIV-1-Infected Individual (2003)

The neutralizing Ab response after primary HIV-1 infection is delayed relative to the virus-specific CD8(+) T cell response and the initial decline in plasma viremia. Because nearly all HIV-1 infections result in AIDS, it would be instructive to study cases where neutralizing Ab production commenced sooner. This was done in subject AC10, an individual treated during early infection and in whom a rapid autologous neutralizing Ab response was detected after therapy cessation as rebound viremia declined and remained below 1000 RNA copies/ml of blood for over 2.5 years. This subject's Abs were capable of reducing the infectivity of his rebound virus by >4 logs in vitro at a time when rebound viremia was down-regulated and virus-specific CD8(+) T cells were minimal, suggesting that neutralizing Abs played an important role in the early control of viremia. The rebound virus did not exhibit an unusual phenotype that might explain its high sensitivity to neutralization by autologous sera. Neutralization escape occurred within 75 days and was proceeded by neutralizing Ab production to the escape variant and subsequent escape. Notably, escape was not associated with a significant rise in plasma viremia, perhaps due to increasing CD8(+) T cell responses. Sequence analysis of gp160 revealed a growing number of mutations over time, suggesting ongoing viral evolution in the face of potent antiviral immune responses. We postulate that an early effective neutralizing Ab response can provide long-term clinical benefits despite neutralization escape.
Distribution of CA 125 in Adenocarcinomas: <i>An Immunohistochemical Study of 481 Cases</i> (1992)

To determine the distribution of CA 125 in adenocarcinomas, formalin-fixed, paraffin-embedded tissue from 481 cases of adenocarcinoma from a variety of primary sites were studied using a monoclonal antibody to CA 125 (B27.1) and an avidin-biotin immunohistochemical technique. Positive reactivity was most common in adenocarcinomas of the endocervix, ovary, and endometrium (61% to 94%). However, relatively frequent positive reactions also were seen in adenocarcinomas of the pancreas (48%) and bile ducts (56%). Adenocarcinomas of the breast, lung, thyroid, distal esophagus/stomach, and liver (hepatocellular carcinoma) showed positive reactions in 7% to 20% of cases. Staining of rare tumor cells was seen in 2 of 45 colonic adenocarcinomas and in 1 of 61 prostatic adenocarcinomas. No reactivity was seen in the 54 renal cell carcinomas studied. Although CA 125 is most commonly present in gynecologic adenocarcinomas, it is also produced by some adenocarcinomas from many other sites. Immunostaining for CA 125 may be helpful in ruling out renal cell carcinoma in certain clinical settings.
Electroplating of Plastics in Theory and Practice (1970)

Abstract Electroplated plastics combine many advantages of plastics and of metals; they have the low weight and ease of shaping of plastics, together with the luster, hardness, and electrical conductivity of metals. An important part of any process for the electroplating of plastics is a pretreatment to ensure good adhesion of the metal film. Etch activation in the straight‐through method requires only six steps for pretreatment.
Milky Spots in the Human Greater Omentum (1989)

Macroscopic and histological investigations were made from surgical specimens demonstrating milky spots in the human greater omentum from subjects of various ages. The milky spots in the human greater omentum appear as tiny, cotton-wool-like masses to the naked eye. Histologically, the milky spots consisted mainly of many macrophages with diffuse cytoplasmic esterase reaction products and esterase-negative B lymphocytes surrounding the vascular networks. Macrophages phagocytosed many carbon particles which were introduced as a carbon suspension during the operation. The vascular networks were blood capillary convolutions with a glomerular shape. Silver impregnation showed the delicate networks of reticular fibers which constitute the framework of the organ. The number of milky spots was highest in infancy and gradually decreased with age.