gebhart/patrepeval huggingface dataset:
Multiple metal-carbon bonds. 34. Why terminal alkynes cannot be metathesized. Preparation and crystal structure of a deprotonated tungstacyclobutadiene complex, W(.eta.5-C5H5)[C3(CMe3)2]Cl (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMultiple metal-carbon bonds. 34. Why terminal alkynes cannot be metathesized. Preparation and crystal structure of a deprotonated tungstacyclobutadiene complex, W(.eta.5-C5H5)[C3(CMe3)2]ClLaughlin G. McCullough, Mark L. Listemann, Richard R. Schrock, Melvyn Rowen Churchill, and Joseph W. ZillerCite this: J. Am. Chem. Soc. 1983, 105, 22, 6729–6730Publication Date (Print):October 1, 1983Publication History Published online1 May 2002Published inissue 1 October 1983https://doi.org/10.1021/ja00360a040RIGHTS & PERMISSIONSArticle Views495Altmetric-Citations90LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (301 KB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
A Carbon-Wrapped Nanoscaled Thermometer for Temperature Control in Biological Environments (2008)

This study is a proof-of-concept that the functionalized CNTs can be used as a contactless thermometer in biomedical applications.
Electrochemical Characteristics of MCMB and LiNi[sub x]Co[sub 1−x]O[sub 2] Electrodes in Electrolytes with Stabilizing Additives (2008)

As part of our continuing efforts to develop advanced electrolytes to improve the performance of lithium-ion cells, especially over wide temperature ranges, we have identified electrolyte additives that can be incorporated into multicomponent electrolyte formulations that result in performance enhancement. Specifically, when electrolyte additives, such as dimethyl acetamide (DMAc) and N-methyl pyrrolidinone, are added to ternary mixtures of carbonates, improved resilience to high-temperature exposure is achieved. A number of experimental lithium-ion cells, consisting of mesocarbon microbead (MCMB) carbon anodes and LiNi0.8 Co0.2 O2 cathodes, have been fabricated to study the effect that these additives have upon the performance. In addition to investigating the use of Lewis base additives that are envisioned to complex any free PF5, other solid electrolyte interface promoting additives were also studied, including vinylene carbonate (VC) and vinyl ethylene carbonate. Significant improvement in the high-temperature resilience of Li-ion cells containing these additives was observed, with the most dramatic benefit being displayed by the addition of DMAc. When the electrochemical properties of the individual electrodes were analyzed, the degradation of the anode kinetics was slowed most dramatically by the incorporation of DMAc and the greatest retention in the cathode kinetics was observed when VC was added. © 2008 The Electrochemical Society.
Virtual reality and telepresence (1992)

SUMMARY The UK Advanced Robotics Research Centre's VERDEX Project (Virtual Environment demote Driving Experiment) is an experimental test bed for investigating telepresence and virtual reality technologies in the design of human-system interfaces for telerobots. The achievements of the Project to date include the transformation of scanning laser rangefinder output to stereo virtual imagery (viewed using the VPL EyePhone TM ), the Teletact® Tactile Feedback Glove (for use with the VPL DataGlove TM ), a high-speed, head-slaved stereo TV system, and a T800/i860 SuperVision TM graphics/video parallel processing system.
ALUMINIUM ALLOYS FOR OFFSHORE DRILLING SYSTEMS (1995)

This paper presents the experience gained in the USSR (now CIS) over many years in the use of Aluminum Drill Pipe (ADP). The main advantages of aluminium over steel for drill pipe applications are discussed. Methods of fabricating aluminium pipes with steel tool joints are explained. The problems of abrasion and corrosion resistance are presented. Recent experience testing ADP after exposure to the offshore environment have shown negligible reduction in fatigue life. It is now considered possible to design a slimline riser in aluminium for water depths of 3-4 kilometres.
Betamethasone valerate foam 0.12%: a novel vehicle with enhanced delivery and efficacy (1999)

A novel foam formulation with enhanced BMV bioavailability has been shown to be of increased efficacy in the treatment of scalp psoriasis without an associated increase in toxicity.
Wavelet-based post-processing of low bit rate transform coded images (2002)

We propose a novel method based on wavelet thresholding for enhancement of decompressed transform coded images. Transform coding at low bit rates typically introduces artifacts associated with the basis functions of the transform. In particular, the method works remarkably well in "deblocking" of DCT compressed images. The method is nonlinear, computationally efficient, and spatially adaptive and has the distinct feature that it removes artifacts yet retain sharp features in the images. An important implication of this result is that images coded using the JPEG standard can efficiently be postprocessed to give significantly improved visual quality in the images. The algorithm can use a conventional JPEG encoder and decoder for which VLSI chips are available.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The Evolution of Marketing Thought in Change-Agent Discipline (1987)

The Evolution of Marketing Thought in Change-Agent Discipline
Elections of Yakima County in Pioneer Days Compared With the Recent Election (1935)

We see that the vote of Yakima County has increased from 130 votes in 1870, the second election, to 19,603 on November 6, 1934.
True (2000)

Ectopic production of free beta human chorionic gonadotrophin (hCGbeta) by bladder carcinoma is well described and occurs in approximately 35% of cases. hCGbeta secreting tumours are more aggressive, radioresistant and have a greater propensity to metastasize. We proposed that the ectopic production of hCGbeta was contributing in an autocrine fashion to the radioresistance and metastatic potential of such secreting tumours. Though we demonstrated that the addition of hCGbeta to the culture media of bladder, cervical and endometrial carcinoma cell lines brought about an increase in cell populations this was not accompanied by a significant increase in the rate of replication. Since a cell population size is a balance of mitosis and mortality, we proposed that hCGbeta was inhibiting apoptosis. Here we have demonstrated that following incubation with recombinant hCGbeta, bladder carcinoma cells refrain from undergoing apoptosis. Quantitation of apoptotic bodies was carried out by immunoassay and corrected to cell number as determined by MTT assay. In each cell line, addition of hCGbeta reduced the number of apoptotic bodies dose-dependently, indicating a diminished apoptotic rate. Furthermore, TGFbeta1-induced apoptosis could be dose-dependently inhibited by co-incubation with hCGbeta. We propose, therefore, that such a decline in apoptosis may account for the cell population increase previously reported. It may also explain the radioresistance and aggressive nature of hCGbeta-secreting tumours and the poor prognosis associated therein.
The Replicator of the Epstein-Barr Virus Latent Cycle Origin of DNA Replication, <i>oriP</i> , Is Composed of Multiple Functional Elements (2001)

Replication of the Epstein-Barr virus genome initiates at one of several sites in latently infected, dividing cells. One of these replication origins is close to the viral DNA maintenance element, and, together, this replication origin and the maintenance element are referred to as oriP. The replicator of oriP contains four binding sites for Epstein-Barr virus nuclear antigen 1 (EBNA-1), the sole viral protein required for the replication and maintenance of oriP plasmids. We showed previously that these EBNA-1 sites function in pairs and that mutational inactivation of one pair does not eliminate replicator function. In this study we characterized the contribution of each EBNA-1 site within the replicator and flanking sequences through the use of an internally controlled replication assay. We present evidence that shows that all four EBNA-1 sites are required for an oriP plasmid to be replicated in every cell cycle. Results from these experiments also show that the paired EBNA-1 binding sites are not functionally equivalent and that the low affinity of sites 2 and 3 compared to that of sites 1 and 4 is not essential for replicator function. Our results suggest that a host cell protein(s) binds sequences flanking the EBNA-1 sites and that interactions between EBNA-1 and this protein(s) are critical for replicator function. Finally, we present evidence that shows that the minimal replicator of oriP consists of EBNA-1 sites 3 and 4 and two copies of a 14-bp repeat that is present in inverse orientation flanking these EBNA-1 sites. EBNA-1 sites 1 and 2, together with an element(s) within nucleotides 9138 to 9516, are ancillary elements required for full replicator activity.
GPS Doppler Processing for Precise Positioning in Dynamic Applications (1985)

In this paper we show that the judicious use of all the information available from C/A code can provide results better than the reported accuracy of P code, with much lower cost. This performance, however, is limited to low-dynamic, low-jamming environments which are typical of civilian applications. The elegance of P-code is primarily manifested in high dynamic vehicles (jets and missiles) and in jamming environments. Results are provided in stationary and low-dynamic cases based on code-phase, carrier-phase, doppler, and integrated doppler measurements from TRIMBLE 4000 receivers. In particular, it is shown that the relative or differential accuracy of better than 10 centimeters can be achieved in low-dynamic applications. Position fixes are obtained every second, after a short time of initial calibration and tracking. The improved accuracy is based on aiding the code-phase measurements with integrated doppler. Each one second position fix, which is provided in both polar and Cartesian coordinates, is based on a complete and independent set of measured data, with no hypothetical modeling, interpolation, or extrapolation.
Essential structural and functional determinants within the forkhead domain of FOXC1 (2004)

The forkhead domain (FHD)-containing developmental transcription factor FOXC1 is mutated in patients presenting with Axenfeld-Rieger malformations. In this paper, we report the introduction of positive, negative or neutral charged amino acids into critical positions within the forkhead domain of FOXC1 in an effort to better understand the essential structural and functional determinants within the FHD. We found that FOXC1 is intolerant of mutations at I87. Additionally, alterations of amino acids within alpha-helix 1 of the FOXC1 FHD affected both nuclear localization and transactivation. Amino acids within alpha-helix 3 were also found to be necessary for transactivation and can have roles in correct localization. Interestingly, changing amino acids within alpha-helix 3, particularly R127, resulted in altered DNA-binding specificity and granted FOXC1 the ability to bind to a novel DNA sequence. Given the limited topological variation of FHDs, due to the high conservation of residues, we anticipate that models of forkhead domain function derived from these data will be relevant to other members of the FOX family of transcription factors.
It's What's on the Inside that Counts - The Chemistry of Floor Polishes (2004)

The chemicals that are typically blended to produce a commercial floor polish are listed and discussed with an emphasis on the properties that each brings to the final formulation and polish film. The distribution and function of the components is followed through polish application and film formation.
Evaluating image steganography techniques: Future research challenges (2013)

Steganography is the art of “concealed writing” and it refers to techniques that hide information inside innocuous looking objects known as “Cover Objects”. There are different types of covers available for embedding secret information but images are pervasive in day to day applications and have high redundancy in representation. Thus, they are appealing contenders to be used as cover objects. This paper evaluates the different algorithms for digital image steganography both in the spatial and transform domain like LSB substitution, OPAP, Pixel Indicator Technique, F5 etc. and tries to put light on some possible future research directions in the topic of consideration.
The Morphology of Human Blood Cells. (1956)

This book adequately fulfills all requirements expected of an atlas on the morphology of the blood cells as observed in the Wright's method of staining. The color plates probably reproduce the true color quality of the stained cells as well as can be done by painting in water color. The material is limited to smears of human blood and bone marrow, and the atlas, therefore, will find its principal use in the clinical laboratory. Quite properly in a volume of this type, no attempt is made to supplement the descriptions of the cells by a treatise on the diseases of the blood. The book is recommended for students in hematology, technicians, and those physicians who find it useful to refer to a publication of this type. The cost and quality should make it highly competitive with similar productions now available. Bruce K. Wiseman, M.D.
Characterization of enzymatically prepared biosurfactants (1996)

Abstract Various fatty monoesters of sugars and sugar alcohols were prepared enzymatically in organic solvent. Water produced during esterification was removed by refluxing through a dessicant under reduced pressure. Surface properties of these esters such as surface and interfacial tensions and their ability to stabilize emulsions at 30°C were evaluated: oleate esters of glucose, fructose, and sorbitol show similar behavior in reduction of surface and interfacial tensions, and values for the critical micelle concentration are about 8·10 −5 M. It was also observed with sorbitol esters that the shorter the alkyl chain, the higher the critical micelle concentration. Generally, emulsions prepared with the emulsifier dissolved in the water or in the oil phase lead to oil‐in‐water or water‐in‐oil emulsions, respectively. Sorbitol monolaurate significantly increased the stability of oil‐in‐water emulsions, with only 5% separation of the phases after 48h at 30°C, compared to 10% for chemically prepared sorbitan monolaurate under the same conditions. Sorbitol monoerucate was very efficient in stabilizing water‐in‐oil emulsions, with only 1% separation of the phases.
Structure-function studies of apoA-I variants:site-directed mutagenesis and natural mutations (2002)

Five mutants of apolipoprotein A-I (apoA-I), apoA-I(Delta63-73), apoA-I(Delta140-150), apoA-I(63-73@140-150), apoA-I(R149V), and apoA-I(P143A) were compared with human plasma apoA-I for their ability to promote cholesterol and phospholipid efflux from HepG2 cells. A significantly lower capacity to promote cholesterol and phospholipid efflux was observed with lipid-free apoA-I(Delta63-73), while mutations apoA-I(Delta140-150) and apoA-I(P143A) affected phospholipid efflux only. When added as apoA-I/palmitoyloleoyl phosphatidylcholine (POPC) complex, mutations apoA-I(63-73@140-150) and apoA-I(Delta140-150) affected cholesterol efflux. None of the mutations affected alpha-helicity of the lipid-free mutants or their self-association. Five natural mutations of apoA-I, apoA-I(A95D), apoA-I (Y100H), apoA-I(E110K), apoA-I(V156E), and apoA-I (H162Q) were studied for their ability to bind lipids and promote cholesterol efflux. None of the mutations affected lipid-binding properties, cholesterol efflux, or alpha-helicity of lipid-free mutants. Two mutations affected self-association of apoA-I: apoA-I(A95D) was more prone to self-association, while apoA-I(E100H) did not self-associate. The following conclusions could be made from the combined data: i) regions 210-243 and 63-100 are the lipid-binding sites of apoA-I and are also required for the efflux of lipids to lipid-free apoA-I, suggesting that initial lipidation of apoA-I is rate limiting in efflux; ii) in addition to the lipid-binding regions, the central region is important for cholesterol efflux to lipidated apoA-I, suggesting its possible involvement in interaction with cells.
The Tissue Kallikrein Family of Serine Proteases: Functional Roles in Human Disease and Potential as Clinical Biomarkers (2004)

Prostate specific antigen (PSA) or human kallikrein 3 (hK3) has long been an effective biomarker for prostate cancer. Now, other members of the tissue kallikrein (KLK) gene family are fast becoming of clinical interest due to their potential as prognostic biomarkers. particularly for hormone dependent cancers. The tissue kallikreins are serine proteases that are encoded by highly conserved multi-gene family clusters in rodents and humans. The rat and mouse loci contain 10 and 25 functional genes, respectively, while the human locus at 19q 13.4 contains 15 genes. The structural organization and size of these genes are similar across species; all genes have 5 coding exons that encode a prepro-enzyme. Although the physiological activators of these zymogens have not been described, in vitro biochemical studies show that some kallikreins can auto-activate and others can activate each other, suggesting that the kallikreins may participate in an enzymatic cascade similar to that of the coagulation cascade. These genes are expressed, to varying degrees, in a wide range of tissues suggesting a functional involvement in a diverse range of physiological and pathophysiological processes. These include roles in normal skin desquamation and psoriatic lesions, tooth development, neural plasticity, and Alzheimer's disease (AD). Of particular interest is the expression of many kallikreins in prostate, ovarian, and breast cancers where they are emerging as useful prognostic indicators of disease progression.
Photosensitive-Ultrasonic Properties of Cadmium Sulfide (1961)

Ultrasonic attenuation in single crystals of CdS has been observed to be a function of light irradiation. Two distinct types of behavior have been observed. Some crystals (type A) show a decrease of attenuation with white light application, and others (type B) show an increase of attenuation with white light. The ultrasonic attenuation and the conductance of the crystals were measured as a function of temperature. An excellent correlation between the conductance and the ultrasonic attenuation is evident for type B crystals. A strong correlation between the directional piezoelectric properties of CdS and the ultrasonic attenuation in both types of CdS is also shown. An interaction between conduction electrons and stress waves coupled by the piezoelectric property of CdS is isolated as the dominant mechanism for the photosensitive ultrasonic attenuation in CdS of type B. Two or more competing effects appear to be responsible for the type A photosensitive attenuation behavior.
Highly Thermal Stable and Efficient Organic Photovoltaic Cells with Crosslinked Networks Appending Open‐Cage Fullerenes as Additives (2014)

Highly thermal stable organic bulk heterojunction (OBHJ) photovoltaic cells are demonstrated with crosslinkable open‐cage fullerenes ( COF ) as additives in the active layer. Partial incorporation of COF , ≈10–15 wt% with weight ratio of P3HT: PC 61 BM = 1:0.9, builds up three‐dimensional local borders upon heating treatment at 150 °C for 10 min. This process induces crosslinking chemical reaction through activating the styryl moiety in COF and reduces phase aggregation rates of fullerenes materials. Supported by statistics of devices degradation data analysis and optical microscopy study, the devices with COF show longer lifetime with keeping their efficiency ( t = 144 h) under accelerated heating test at 150 °C, while PCE of normal devices without COF drop dramatically. These results demonstrate that the thermally crosslinkable COF is an excellent additive for highly thermal stable and durable OPVs applications.
Abstract 19043: Novel Bioactive Peptide Amphiphiles Nanofibers for Enhancement of Human Cd34+ Cell Mediated Ischemic Tissue Repair (2013)

Background: CD34+ cells have shown unprecedented promise for ischemic tissue repair in recent clinical trials; however, their recruitment, retention, and survival in the injured tissue remain one of the major barriers to the success of this novel therapeutic strategy. Methods and Results: In this study, we have developed a self-assembling bioactive peptide amphiphile (PA) nanofiber that displays the integrin-recognized cell adhesion epitope RGDS and then tested this novel scaffold material for therapeutic delivery, retention, and functional support of human CD34+ cells in a mouse model of critical hind-limb ischemia (CLI). In culture, PA nanofibers, but not non-bioactive nanostructures or nanostructures with scrambled DGRS epitope, significantly enhanced the adhesion and survival of human CD34+ cells under a number of cellular stresses. In CLI nude mice, intramuscular injection of human CD34+ cells contained in the RGDS nanostructures led to a significantly better blood perfusion, motor ability, limb salvage, and treadmill endurance when compared with those of CD34+ cells contained in DGRS nanostructures, cells alone or RGDS alone. Histology analyses revealed a higher viability and retention of CD34+ cells in the limb tissue of the RGDS nanostructures/CD34+ cells group than in the RGDS nanostructures alone or cells alone group. In consistent with the improved functional recovery, the density of capillaries in the ischemic limb of RGDS nanostructures/CD34+ cells group was significantly greater than in other groups. Conclusions: Our data demonstrate that integrin-specific binding epitope RGDS nanostructure enhances viability, adhesion, and angiogenic capability of human CD34+ cells. This pre-clinical study provides a rationale for further investigation of combining RGDS PAs with human CD34+ cells to enhance the effectiveness of cell therapy for ischemic limb disease.
Cloning and expression of beta 2-glycoprotein 1 recognized by antiphospholipid antibodies and its clinical investigation. (1999)

It is indicated that antigenic epitope of beta 2 GP1 might be located in its fifth domain. Detection of anti-r beta 2GP1 antibodies may be of potential value for evaluating the risk of thrombosis and/or other APS associated symptom.