gebhart/patrepeval huggingface dataset:
A modular gradient‐sensing network for chemotaxis in <i>Escherichia coli</i> revealed by responses to time‐varying stimuli (2010)

The Escherichia coli chemotaxis-signaling pathway computes time derivatives of chemoeffector concentrations. This network features modules for signal reception/amplification and robust adaptation, with sensing of chemoeffector gradients determined by the way in which these modules are coupled in vivo. We characterized these modules and their coupling by using fluorescence resonance energy transfer to measure intracellular responses to time-varying stimuli. Receptor sensitivity was characterized by step stimuli, the gradient sensitivity by exponential ramp stimuli, and the frequency response by exponential sine-wave stimuli. Analysis of these data revealed the structure of the feedback transfer function linking the amplification and adaptation modules. Feedback near steady state was found to be weak, consistent with strong fluctuations and slow recovery from small perturbations. Gradient sensitivity and frequency response both depended strongly on temperature. We found that time derivatives can be computed by the chemotaxis system for input frequencies below 0.006 Hz at 22 degrees C and below 0.018 Hz at 32 degrees C. Our results show how dynamic input-output measurements, time honored in physiology, can serve as powerful tools in deciphering cell-signaling mechanisms.
Advertising cached contents in the control plane: Necessity and feasibility (2012)

A key feature of Information-Centric Networking architectures is universal caching where anyone can cache any content and users can obtain the content from anywhere as long as the content itself is intact. This powerful feature benefits the content providers, the Internet service providers (ISPs) as well as end users since the requested content can be fetched from the nearest cache who is able to satisfy the request. Hence, server load, redundant network traffic and fetch latency are all reduced. However, given the huge number of contents in the Internet and the rapid replacement of cached contents, designing a scalable routing protocol to reach the full potential of universal caching is very challenging. Previous proposal in [1] tackles the problem by only considering contents on original servers in the control plane and opportunistically exploring cached contents in the data plane via so-called forwarding strategy. In this paper we argue that, to unleash the full potential of Information-Centric Networking, cached contents should be taken into consideration in the control plane and propose a specific scheme to achieve that. We believe addressing cached contents in the control plane (even imperfectly) is more efficient than “guessing” them in the data plane.
Film growth of pillars of multi-walled carbon nanotubes (2003)

Using ferrocene as the catalyst and xylene as the precursor, films of multi-walled carbon nanotubes (CNTs) that are well aligned can be synthesized on flat substrates by chemical vapour deposition. Here we report that, by controlling the growth speed of CNTs at specific catalyst/carbon ratios, vertically aligned pillars of densely packed nanotubes with uniform diameters (within 10–30 µm) and lengths of up to 0.3–0.4 mm can be fabricated on a large scale on planar SiO2 substrates, forming a continuous film. The growth mechanism of the pillars was also investigated by observing the growth of CNTs at different growth stages.
Oothecal structure and male genitalia of the Geoscapheinae and some Australian <i>Panaesthia</i> Serville (Blattodea: Blaberidae) (1998)

Abstract Oothecal structure and male genitalia of Geoscapheinae and some species of Australian Panaesthia are examined and discussed. Within Geoscapheinae two forms of oviposition behaviour exist. the first is similar to that of Panaesthia where a double row of eggs is partially enclosed in a thin membrane. the second form consists of a loosely appressed mass of eggs without a membrane. In both forms eggs are stored in an internal brood sac. Male genitalia within Panaesthia is relatively conservative, showing little interspecific variation; however, not all species possess the L2d phallomere. Among Geoscapheinae, male genitalia vary greatly from almost a full complement to nearly a complete absence of blaberid phallomeres. Some Geoscapheinae exhibit intraspecific variation of the L1 and R2 phallomeres.
Electrochemical and spectroscopic study of the transport properties of composite polymer electrolytes (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectrochemical and spectroscopic study of the transport properties of composite polymer electrolytesF. Croce, B. Scrosati, and G. MariottoCite this: Chem. Mater. 1992, 4, 6, 1134–1136Publication Date (Print):November 1, 1992Publication History Published online1 May 2002Published inissue 1 November 1992https://pubs.acs.org/doi/10.1021/cm00024a003https://doi.org/10.1021/cm00024a003research-articleACS PublicationsRequest reuse permissionsArticle Views347Altmetric-Citations55LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A single supply high performance PA MMIC for GSM handsets using quasi-enhancement mode PHEMT (2002)

A 3-stage GaAs FET power amplifier MMIC utilizing a quasi-enhancement mode PHEMT process has been developed for single supply GSM applications. The MMIC operates from a 3.2 V power supply and at 900 MHz, provides 35.5 dBm output power and 63.0% power added efficiency. Another 3 stage MMIC designed for DCS-1800, which at 1750 MHz provides 33.2 dBm output power with 61.1% PAE, is also presented.
An optically sampled wideband digital receiver (2004)

Phase-encoded optical sampling allows the processing of RF and microwave signals with high linearity and >60-dB signal-to-noise ratio in an optically sampled digital receiver. The wide analog-input bandwidth (>1 GHz) enables novel processing capabilities as demonstrated for a 250-MHz-bandwidth chirped signal undersampled at 60 MS/s.
Identification of a Novel Cardenolide (2‘ ‘-Oxovoruscharin) from <i>Calotropis </i><i>p</i><i>rocera</i> and the Hemisynthesis of Novel Derivatives Displaying Potent in Vitro Antitumor Activities and High in Vivo Tolerance:  Structure−Activity Relationship Analyses (2005)

Analysis of the methanolic extract of Calotropis procera root barks enabled the identification of a novel cardenolide (2''-oxovoruscharin) to be made. Of the 27 compounds that we hemisynthesized, one (23) exhibited a very interesting profile with respect to its hemisynthetic chemical yield, its in vitro antitumor activity, its in vitro inhibitory influence on the Na+/K+-ATPase activity, and its in vivo tolerance. Compound 23 displayed in vitro antitumor activity on a panel of 57 human cancer cell lines similar to taxol, and higher than SN-38 (the active metabolite of irinotecan), two of the most potent drugs used in hospitals to combat cancer.
Sore Nipples in Breast-feeding Women (1998)

Prevention of sore nipples by teaching proper technique on the initiation of breast-feeding should be instituted. For those cases in which sore nipples do develop, breast shells and lanolin in association with instruction in breast-feeding technique are more effective than moist wound dressings. Lanolin and shells should remain first-line therapy.
Sensing surface shape by touch (2002)

The design and construction of a tactile sensor that has been developed to measure the surface shape of objects held between the fingers of a robot gripper are described. A robotic tactile sensory workcell has been assembled to investigate touch-mediated grasping and object manipulation. This system requires sensors to provide surface profile information for experiments involving object manipulation and shape determination. A piezoresistive tactile sensor originally developed for the workcell proved to be generally unsuitable because its stiff sensing surface gave little surface shape information. A solution was provided by a tactile sensor designed to have a compliant structure.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
An Adaptive Fault Location Technique Based on PMU for Transmission Line (2007)

A new adaptive fault location technique based on Phasor Measurement Unit (PMU) for transmission line is presented in this paper. Voltage and current phasors of both terminals of the transmission line are obtained through PMU. The online parameter-calculation algorithm is adopted to obtain the practical operating parameters when fault occurs, solving the problems that parameters provided by electric power company is different from the practical parameters because of the running environment and the operation history. The suddenly changed voltage and current are utilized to obtain suddenly changed positive voltage and current components to solve the system's impedance at the fault time. The on-line calculated system's impedance and parameters of the line are employed in the fault location equation and the fault location accuracy is high. The proposed fault location method is applied in single transmission line, parallel transmission line as well as teed transmission line. Extensive EMTP simulations as well as practical system data testing results have shown that the proposed technique accurately locate the fault point adaptively, not influenced by factors such as operation mode, fault resistance at fault point, fault type, prefault load and fault distance.
Bee-sticks, an Aid in Pollinating Cruciferae1 (1980)

Abstract Effective, inexpensive, disposable pollination aids (bee-sticks) can be made by gluing the thoraxes of dead honey bees ( Apis mellifera L.) to the tips of wooden toothpicks. Bee-sticks also are suitable for the short and long term storage and for shipment of pollen.
Pharmacological control of opioid-induced pruritus: a quantitative systematic review of randomized trials (2001)

Background and objective Numerous drugs have been used to prevent or to treat opioid-induced pruritus in the surgical setting. Their relative efficacy is not well understood. Methods The methods employed involved the systematic search (MEDLINE, EMBASE, Cochrane library, bibliographies, without language restriction, up to June 2000) for full reports of randomized comparisons of any intervention which is thought to be anti-pruritic (active) compared with placebo or no treatment (control) in surgical (including labour) patients receiving opioids. The number of patients who had no pruritus were analysed using relative risk and number-needed-to-treat with 95% confidence interval. Results Twenty-two trials (1477 patients) were analysed. Two trials (66 patients), both with low-dose propofol, were on treatment of established pruritus; propofol had no anti-pruritic effect compared with Intralipid. In prophylaxis trials, the average incidence of pruritus with control was 59% (range, 10% to 100%). Most mu-receptor antagonists were efficacious: intravenous naloxone 0.25–2.4 µg kg−1 h−1, relative risk 2.31 (95% confidence interval, 1.5 to 3.54), number-needed-to-treat to prevent pruritus compared with control 3.5; oral naltrexone 9 mg, relative risk 2.80 (1.35–5.80), number-needed-to-treat 1.7; naltrexone 6 mg was less effective and 3 mg did not work; different intravenous and epidural nalbuphine regimens, relative risk 1.71 (1.12–2.62), number-needed-to-treat 4.2. Intravenous nalmefene 0.5 or 1 mg was not anti-pruritic. Intravenous (but not epidural) droperidol 2.5 mg was efficacious, relative risk, 1.71 (1.28–2.29), number-needed-to-treat 4.9. There was a lack of evidence for any anti-pruritic efficacy with prophylactic propofol, epidural or intrathecal epinephrine, epidural clonidine, epidural prednisone, intravenous ondansetron, or intramuscular hydroxyzine. Conclusion Naloxone, naltrexone, nalbuphine and droperidol are efficacious in the prevention of opioid-induced pruritus; minimal effective doses remain unknown. There is a lack of valid data on the efficacy of interventions for the treatment of established pruritus.
A 2.5W tablet speaker delivering 3.2W pseudo high power by psychoacoustic model based adaptive power management system (2014)

For a 2.5W speaker in tablets, the proposed adaptive power management (APM) system can deliver a pseudo high power of 3.2W with a ±4V supply because it suppresses 0.7W power on tones that may damage a 2.5W speaker and escape the notice of human ears. With z-domain digital signal processing (z-DSP) and psychoacoustic model, high efficient power management and high sound quality can be achieved simultaneously. Conventional automatic gain control (AGC) only has the ability of 0.32W power suppression. Moreover, suppressing power by conventional clipping technique increases total-harmonic-distortion (THD). In contrast, the proposed real-time dynamic loading impedance (RT-DLI) monitoring brings forward a way to solve the problem on speaker damage while keeping low THD during high sound pressure level (SPL). THD in the APM system is slightly higher than that of original sound 1.1dB, comparing to the disadvantage of 8.6dB increasing caused by conventional clipping technique.
Synthesis and Characterization of EMPO-Derived 5,5-Disubstituted 1-Pyrroline N-Oxides as Spin Traps Forming Exceptionally Stable Superoxide Spin Adducts (2003)

EMPO [5-(ethoxycarbonyl)-5-methyl-1-pyrroline N-oxide] is a highly hydrophilic cyclic nitrone spin trap, whose superoxide adduct is considerably more stable (t 1/2 = 8.6 min) than DMPO (5,5-dimethyl-1-pyrroline N-oxide, t 1/2=45 s). EPR spectra of spin adducts of EMPO and its derivatives are very similar to those of the respective DMPO spin adducts, in contrast to the rather complex spectra obtained using DEPMPO [5-(diethoxyphosphoryl)-5-methyl-1-pyrroline N-oxide]. Several EMPO derivatives, with both the ethoxycarbonyl group and the methyl group at position 5 of the pyrroline ring being replaced by other substituents, were synthesized and characterized by 1H and 13C NMR spectroscopy. Thus, a series of derivatives was obtained that exhibit large differences in the stability of their superoxide adducts, ranging from less than one to more than 25 min. The stability of the superoxide adducts was mainly determined by the steric environment of the nitroxyl group: in compounds with less bulky 5-alkoxycarbonyl substituents the nitroxyl group is sterically less shielded, which resulted in a lower stability of the superoxide adducts. The spin density distribution, as obtained from DFT computations, was found to be nearly identical for all compounds, so that in contrast to the steric influences the spin density did not seem to be a crucial factor for the stability of the superoxide adducts.
Neutralizing monoclonal antibodies that distinguish three antigenic sites on human cytomegalovirus glycoprotein H have conformationally distinct binding sites (1993)

Seven neutralizing murine monoclonal antibodies specific for the glycoprotein H of human cytomegalovirus were produced and used to construct a topological map of two nonoverlapping antigenic sites that are bridged by a third antigenic site. Neutralization assays with 15 laboratory or clinical human cytomegalovirus strains indicated that the monoclonal antibodies recognize three antigenically variable and three conserved epitopes within the three antigenic sites. The variable-domain genes encoding monoclonal antibodies representing each of the three antigenic sites were cloned and sequenced, and molecular models of their binding sites were generated. Conformational differences in the antibody-binding sites suggested a structural basis for experimentally observed differences in gH epitope recognition.
Discovery of 1,3-Diaminobenzenes as Selective Inhibitors of Platelet Activation at the PAR1 Receptor (2012)

A high-throughput screen of the NIH-MLSMR compound collection, along with a series of secondary assays to identify potential targets of hit compounds, previously identified a 1,3-diaminobenzene scaffold that targets protease-activated receptor 1 (PAR1). We now report additional structure-activity relationship (SAR) studies that delineate the requirements for activity at PAR1 and identify plasma-stable analogues with nanomolar inhibition of PAR1-mediated platelet activation. Compound 4 was declared as a probe (ML161) with the NIH Molecular Libraries Program. This compound inhibited platelet aggregation induced by a PAR1 peptide agonist or by thrombin but not by several other platelet agonists. Initial studies suggest that ML161 is an allosteric inhibitor of PAR1. These findings may be important for the discovery of antithrombotics with an improved safety profile.
On Seismic Computations, With Applications, II1Published by permission of the Board of Directors, Humble Oil and RefiningCompany. (1936)

Abstract This paper is a continuation of a previous one given, with a somewhat similar title, in which are discussed the travel-times and other similar properties of the wave paths in a medium in which the seismic velocity is an integrable function of the depth. In this paper we consider similar properties of the waves from a point on the surface to a point in a “well” in such a medium.
Amifostine for protection from antineoplastic drug toxicity (1997)

The mechanism of action, pharmacokinetics, clinical efficacy, adverse effects, and dosage and administration of amifostine are reviewed. Amifostine is a prodrug converted by alkaline phosphatase to the active sulfhydryl compound WR-1065. WR-1065 protects normal cells by scavenging free radicals, donating hydrogen ions to free radicals, depleting oxygen, and binding to active derivatives of antineoplastic agents. The immediate conversion of amifostine to WR-1065, its small volume of distribution, and the limited amount of drug and metabolite recovered in the urine suggest that amifostine is rapidly dephosphorylated and enters cells as its active metabolite. The selectivity of amifostine for normal tissue is hypothesized to be a results of the decreased vascularity of tumors, decreased activity of alkaline phosphatase in tumor cells, and pH dependence of WR-1065 uptake. In clinical studies, amifostine decreased the frequency of cisplatin-induced nephrotoxicity, ototoxicity, neurotoxicity, and myelosuppression. Amifostine has demonstrated an ability to decrease the hematologic toxicity of cyclophosphamide, carboplatin, mitomycin, and antineoplastic drug combinations. Amifostine has FDA-approved labeling for use in reducing cumulative renal toxicity in patients receiving repeat doses of cisplatin for advanced ovarian cancer and non-small-cell lung cancer. The recommended dose in adults is 910 mg/m2 administered as a 15-minute infusion 30 minutes before the start of chemotherapy. The major adverse effects of amifostine include hypotension and emesis. The benefits of amifostine must be weighted against its potential adverse effects, and the drug's impact on the efficacy of antineoplastics should be further investigated. Amifostine has shown promise in protecting non-malignant cells from the toxic effects of antineoplastics, apparently without compromising toxicity against cancer cells.
Tests of Tri-Axial HTS Cables (2005)

The Ultera/ORNL team have built and tested 3-m and 5-m triaxial cables rated at 3 and 1.3 kA-rms, respectively. The three concentric superconducting phases are made of BSCCO-2223 HTS tapes, separated by layers of cold-dielectric tapes. A copper braid is added as the grounding shield on the outside of the three active phases. Tests of these cables were performed at temperatures ranging from 70 to 84 K. AC loss data reconfirmed the previous result on a 1.5-m prototype cable that the total 3-phase ac loss is about the sum of the calculated ac losses of the three concentric phases. These and other test results of the 1.3 and 3 kA cables will be used to construct a second 5-m triaxial cable rated at 3 kA-rms, 15 kV. Preliminary test results supporting this new cable and the associated termination are summarized.
GABA-Activated Ligand Gated Ion Channels:  Medicinal Chemistry and Molecular Biology (2000)

ADVERTISEMENT RETURN TO ISSUEPerspectiveNEXTGABA-Activated Ligand Gated Ion Channels: Medicinal Chemistry and Molecular BiologyMary Chebib and Graham A. R. JohnstonView Author Information Adrien Albert Laboratory of Medicinal Chemistry, Department of Pharmacology, University of Sydney, Sydney, New South Wales 2006, Australia Cite this: J. Med. Chem. 2000, 43, 8, 1427–1447Publication Date (Web):March 30, 2000Publication History Received24 August 1999Published online30 March 2000Published inissue 1 April 2000https://pubs.acs.org/doi/10.1021/jm9904349https://doi.org/10.1021/jm9904349review-articleACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views3288Altmetric-Citations265LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Agonists,Antagonists,Genetics,Receptors,Rodent models Get e-Alerts
A Versatile Digital Pulsewidth Modulation Architecture with Area-Efficient FPGA Implementation (2006)

This paper describes a multi-output digital pulsewidth modulator (DPWM) that generates versatile waveforms suitable for use in a typical multi-phase interleaved switching DC-DC buck converter. A heterogenous DPWM is proposed that achieves a resolution of 255 ps, facilitating multi-megahertz switching frequencies. A novel global architecture is also introduced that exploits the phased nature of the interleaved buck converter, limiting the number of required multiplexers/comparators and enabling a large, adjustable number of variable-frequency pulsewidth modulated outputs to be generated using a small, xed architecture with programmable duty-cycles and dead-times