gebhart/patrepeval huggingface dataset:
Genetics of <i>Methanococcus</i>: possibilities for functional genomics in Archaea (1999)

Although the genomic sequences of a number of Archaea have been completed in the last three years, genetic systems in the sequenced organisms are absent. In contrast, genetic studies of the mesophiles in the archaeal genus Methanococcus have become commonplace following the recent developments of antibiotic resistance markers, DNA transformation methods, reporter genes, shuttle vectors and expression vectors. These developments have led to investigations of the transcription of the genes for hydrogen metabolism, nitrogen fixation and flagellin assembly. These genetic systems can potentially be used to analyse the genomic sequence of the hyperthermophile Methanococcus jannaschii, addressing questions of its physiology and the function of its many uncharacterized open reading frames. Thus, the sequence of M. jannaschii can serve as a starting point for gene isolation, while in vivo genetics in the mesophilic methanococci can provide the experimental systems to test the predictions from genomics.
Role of overexpression of CD151 and/or c-Met in predicting prognosis of hepatocellular carcinoma # (2008)

CD151 is positively associated with invasiveness of HCC, and CD151 or combination of CD151/c-Met is a novel marker in predicting the prognosis of HCC and a potential therapeutic target.
Three-dimensional finite element model of a human mandible incorporating six osseointegrated implants for stress analysis of mandibular cantilever prostheses. (1995)

The three-dimensional finite element stress analysis method was used to determine the distribution of stresses in and around a model of six implants which supported a typical fixed complete-arch prosthesis in a simulated human mandible. A load of 100 N was applied at different intervals along the cantilever segment. There was a decrease of stress that reached a minimal level at 15 mm along the cantilever segment. Thereafter, a progressive increase of stresses in the lingual and buccal plates was demonstrated.
New OPC verification method using die-to-database inspection (2006)

The minimum feature size of new generation memory devices is approaching down to 50 nm era. And a very precise CD control is demanded not only for cell layouts but also for core and peripheral layouts of DRAM devices. However, as NA of lens system grows higher and higher and Resolution Enhancement Techniques (RETs) becomes more and more aggressive, isolated-dense bias increases and process window for the core and peripheral layouts decreases dramatically. So, the burden of OPC increases in proportion and it is requisite to verify as many features as possible on wafer. If possible, it would be desirable to verify all the features in a die. Recently, a novel inspection tool has been developed which can verify all kinds of patterns on wafer based on Die to Database copmarison method. It can identify all the serious systematic defects of nm order size error from the original layout target and feed back the systematic error points to OPC for more accurate model tuning. In addition we can obtain the full field CD distribution diagram of some specific transistors with hundreds of thousands of measurement data. So, we can analyze the root cause of the CD distribution in a field, such as mask CDU or lens aberrations and so on. And we can also perform Process Window Qualification of all the features in a die. In this paper, OPC verification methodology using the new inspection tool will be introduced and the application to the analysis of full field CD distribution and Process Window Qualification will be presented in detail.
Image sequence stabilisation using fuzzy adaptive Kalman filtering (2003)

Image sequence stabilisation based on fuzzy adaptive Kalman filtering of absolute frame displacements is proposed. Two Kalman filters are operated in parallel, one of which is used as a reference filter and is run with a constant high process noise variance to enable smooth and close tracking of global camera displacements. The process noise variance of the stabilisation filter is adaptively varied according to the residual between the stabilisation filter and the reference filter output.
The historical and current interest in coumarin (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe historical and current interest in coumarinJohn Leo Abernethy Cite this: J. Chem. Educ. 1969, 46, 9, 561Publication Date (Print):September 1, 1969Publication History Received3 August 2009Published online1 September 1969Published inissue 1 September 1969https://doi.org/10.1021/ed046p561RIGHTS & PERMISSIONSArticle Views962Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (6 MB) Get e-Alertsclose Get e-Alerts
A 60 GHz low noise variable gain amplifier with small noise figure and IIP3 variation in a 40-nm CMOS technology (2018)

This paper presents the design and measurement of a low noise variable gain amplifier (VGA) over the frequency band of 57 GHz and 64 GHz, using 40-nm CMOS technology. The design applies an inductive degeneration technique for simultaneously noise and power matching, a layout gate inductance for gain frequency extension, and current steering technique for gain tuning. The comparison of a low noise amplifier (LNA) and a low noise VGA is done, in terms of noise figure and linearity (IIP3). The LNA achieves 6.7 dB gain and 4.3 dB noise figure (NF) at 60 GHz, while consuming 12 mA from a 1.1 V supply. The IIP3 of the LNA is -12.8 dBm. The VGA has an S <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">21</sub> of 6.67 dB (maximum) and 5.1 dB NF at 58 GHz. The gain tuning range is 6 dB and the NF deviation is 0.8 dB at 60 GHz and the IIP3 is -7.66 dBm at the maximum gain state. The supply voltage of the VGA is 1.1 V and the DC current is 11 mA.
Method for the synthesis of 4-substituted acetoacetates (1977)

C. B. Troostwijk and R. M. Kellogg, J. Chem. Soc., Chem. Commun., 1977, 932 DOI: 10.1039/C39770000932
Optofluidic platforms based on surface-enhanced Raman scattering (2010)

We report recent progress in the development of surface-enhanced Raman scattering (SERS)-based optofluidic platforms for the fast and sensitive detection of chemical and biological analytes. In the current context, a SERS-based optofluidic platform is defined as an integrated analytical device composed of a microfluidic element and a sensitive Raman spectrometer. Optofluidic devices for SERS detection normally involve nanocolloid-based microfluidic systems or metal nanostructure-embedded microfluidic systems. In the current review, recent advances in both approaches are surveyed and assessed. Additionally, integrated real-time sensing systems that combine portable Raman spectrometers with microfluidic devices are also reviewed. Such real-time sensing systems have significant utility in environmental monitoring, forensic science and homeland defense applications.
SRPK1 Inhibition Modulates VEGF Splicing to Reduce Pathological Neovascularization in a Rat Model of Retinopathy of Prematurity (2013)

These results suggest that splicing regulation through selective downregulation of proangiogenic VEGF isoforms (via SRPK1 inhibition) or competitive inhibition of VEGF signaling by rhVEGF165b has the potential to be an effective alternative to potential cyto- and neurotoxic anti-VEGF agents in the treatment of pathological neovascularization in the eye.
Healing of Planar Defects in 2D Materials via Grain Boundary Sliding (2019)

Understanding the mechanisms and kinetics of defect annihilations, particularly at the atomic scale, is important for the preparation of high-quality crystals for realizing the full potential of 2D transition metal dichalcogenides (TMDCs) in electronics and quantum photonics. Herein, by performing in situ annealing experiments in an atomic resolution scanning transmission electron microscope, it is found that stacking faults and rotational disorders in multilayered 2D crystals can be healed by grain boundary (GB) sliding, which works like a "wiper blade" to correct all metastable phases into thermodynamically stable phases along its trace. The driving force for GB sliding is the gain in interlayer binding energy as the more stable phase grows at the expanse of the metastable ones. Density functional theory calculations show that the correction of 2D stacking faults is triggered by the ejection of Mo atoms in mirror twin boundaries, followed by the collective migrations of 1D GB. The study highlights the role of the often-neglected interlayer interactions for defect repair in 2D materials and shows that exploiting these interactions has significant potential for obtaining large-scale defect-free 2D films.
Insights into MMP‐TIMP Interactions (1999)

The proteolytic activity of the matrix metalloproteinases (MMPs) involved in extracellular matrix degradation must be precisely regulated by their endogenous protein inhibitors, the tissue inhibitors of metalloproteinases (TIMPs). Disruption of this balance can result in serious diseases such as arthritis and tumor growth and metastasis. Knowledge of the tertiary structures of the proteins involved in such processes is crucial for understanding their functional properties and to interfere with associated dysfunctions. Within the last few years, several three-dimensional structures have been determined showing the domain organization, the polypeptide fold, and the main specificity determinants of the MMPs. Complexes of the catalytic MMP domains with various synthetic inhibitors enabled the structure-based design and improvement of high-affinity ligands, which might be elaborated into drugs. Very recently, structural information also became available for some TIMP structures and MMP-TIMP complexes, and these new data elucidated important structural features that govern the enzyme-inhibitor interaction.
Interaction of RNA Polymerase with the DNA Template (1976)

INTRODUCTION In the initial phase of RNA synthesis, RNA polymerase interacts with the template to form a binary complex that is able to bind substrates and initiate an RNA chain. This interaction can occur in the absence of the nucleoside triphosphates. In systems where RNA polymerases carry out selective transcription, effective binary complexes are formed primarily at promoter regions of the DNA template. This process of promoter “site selection” is a key point at which cellular regulation of transcription takes place and as such has been subjected to extensive study. With bacterial RNA polymerases and templates that contain certain “major” promoter sites, extremely stable binary complexes can be formed (Pettijohn and Kamiya 1967; Hinkle and Chamberlin 1971, 1972a). RNA polymerase bound in these complexes can initiate RNA chains correctly, without release from DNA, in a very rapid reaction. Thus these “open promoter complexes” are important intermediates in the transcription cycle. The properties of these complexes have also facilitated the isolation (Heyden, Nusslein and Schaller 1972; Okamoto, Sugiura and Takanami 1972; Chen, Hutchison and Edgell 1973) and sequencing (Schaller, Gray and Hermann 1975; Gilbert, this volume) of these regions. However, the process of site selection is not simply explained by tight binding of RNA polymerase to promoter regions. Highly stable complexes can be formed at sites on DNA at which RNA chain initiation cannot occur (Hinkle, Ring and Chamberlin 1972). Conversely, under certain conditions, or with some RNA polymerases, highly stable complexes are not formed even at biologically important promoters (Kupper...
Predictive-corrective incompressible SPH (2009)

We present a novel, incompressible fluid simulation method based on the Lagrangian Smoothed Particle Hydrodynamics (SPH) model. In our method, incompressibility is enforced by using a prediction-correction scheme to determine the particle pressures. For this, the information about density fluctuations is actively propagated through the fluid and pressure values are updated until the targeted density is satisfied. With this approach, we avoid the computational expenses of solving a pressure Poisson equation, while still being able to use large time steps in the simulation. The achieved results show that our predictive-corrective incompressible SPH (PCISPH) method clearly outperforms the commonly used weakly compressible SPH (WCSPH) model by more than an order of magnitude while the computations are in good agreement with the WCSPH results.
On applying set covering models to test set compaction (2003)

Test set compaction is fundamental problem in digital system testing. In recent years, many competitive solutions have been proposed, most of which based on heuristics approaches. This paper studies the application of set covering models to the compaction of test sets, which can be used with any heuristic test set compaction procedure. For this purpose, recent and highly effective set covering algorithms are used. Experimental evidence suggests that the size of computed test sets can often be reduced by using set covering models and algorithms. Moreover a noteworthy empirical conclusion is that it may be preferable not to use fault simulation when the final objective is test set compaction.
An automated system for disaster management based on BRAC standard operating procedures (SOP) (2014)

This thesis report is submitted in partial fulfillment of the requirements for the degree of Bachelor of Science in Computer Science and Engineering, 2014.
Loss of heterozygosity and microsatellite instability in hepatocellular carcinoma in Taiwan (1999)

Elucidation of the basic genetic changes of human hepatocellular carcinoma is important for the understanding and treatment of this cancer. We used microsatellite polymorphism markers to study 30 cases of hepatocellular carcinoma (34 tumours) on all human chromosomes. DNA from 34 pairs of hepatocellular carcinomas and corresponding non-tumour parts was prepared. Loss of heterozygosity (LOH) and microsatellite instability on 23 chromosomes were investigated by 231 sets of microsatellite markers. More than 20% LOH was shown for loci on 16q (47.1%), 13q (32.4%), 17p (32.4%), 5q (26.5%), 11p (23.5%) and 9p (20.6%). The commonly affected regions were mapped to 16q12.1, 16q12.2, 16q24, 13q12.1-32, 17p13, 5q32, 5q34, 5q3, 11p15, 11q23-24 and 9p21. Hepatitis B virus carriers had a significantly higher frequency of LOH on chromosomes 5q, 11p and 16q. Furthermore, larger tumour size tended to have higher frequency of LOH at D16S409 locus (16q12.1). Microsatellte instability was only found in 12 of 231 markers and the frequency is very low. These data suggest that the chromosomes 16q, 13q, 17p, 5q, 11p and 9p might participate in hepatocarcinogenesis. However, microsatellite instability might play little role in the development of this cancer in Taiwan.
Engineering a Titanium Surface with Controllable Oleophobicity and Switchable Oil Adhesion (2010)

We demonstrate techniques to fabricate, for the first time, superoleophobic surfaces on engineered functional titanium either by novel anodization or by a combination of anodization and laser technology. The approach basically involves the formation of microstructures on a Ti surface first and then the formation of TiO2 nanotube arrays above, followed by postmodification of hydrophobic materials. Of particular interest is that the switchable wettability toward superoleophobicity and the reversible adhesion of oil droplets between sliding superoleophobicity and sticky superoleophobicity were realized on these surfaces through the alternate treatment by UV and annealing. The movement of a magnetic oil droplet can be manipulated on the surface by applying an external magnetic field. The applications of the engineered surfaces in oil sealing and anticreeping are demonstrated. The approach represents a key addition to functional superoleophobic materials.
Li/Fe/sub 1-x/Co/sub x/S/sub 2/ system thermal battery performance (2003)

Synthetic disulfides composed of iron and cobalt (Fe/sub 1-x/Co/sub x/S/sub 2/) were evaluated as cathode materials using a single cell. The discharge utilization was improved and the discharge curve exhibited an excellent plateau when compared with those of both FeS/sub 2/ and FeS/sub 2/+CoS/sub 2/ and also the discharge time became longer with an increasing Co atomic ratio. The atomic ratio of iron and cobalt of each sample and the lattice constant obtained from X-ray analysis results are shown. The performances of BL 60210 and BL 72135 thermal batteries using synthetic disulfide cathode materials are described.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Alarm model specification and dynamic multi-layer self-healing mechanisms for commercial and ad-hoc wireless networks (2005)

The wireless information era has created a phenomenal dependence amongst commercial and military applications on wireless networks. Such an increasing reliance in turn implies increasingly serious consequences caused by outages. Hence (i) alarm models that can help efficiently and quickly perform root cause analysis (RCA) and (ii) self-healing mechanisms that can respond to the dynamics of the underlying network and provide rapid recovery of the affected applications, are critical. We recognize the importance of the above and propose appropriate service survivability mechanisms. More specifically, our contributions are as follows. We derive alarm model specifications that can succinctly and accurately capture the network alarms and symptoms for processing by the inferencing (RCA) engine. Next, we propose a dynamic cost and performance-sensitive self-healing mechanism that can adapt to the networks' dynamics and provide rapid and efficient self-healing. The proposed mechanism has the additional feature of being able to be specified in terms of policies, thereby allowing for an easy integration into the rapidly emerging policy-based management framework. The results of our work will benefit both network designers and managers and help (a) not only in increasing customer retention ratios, but also providing increased revenues in the commercial setting and (b) provide the critically needed quick and seamless restoration of military services.
Myeloid-derived Suppressor Cells in Cancer Patients (2012)

Myeloid-derived suppressor cells (MDSCs) represent a heterogenous collection of immature myeloid cells endowed with suppressive function on the immune response. Their presence has been extensively investigated in preclinical models, especially in the context of cancer. One of the major obstacles in their accurate identification has been the definition of an unambiguous phenotype, shared between mice and humans, and clearly correlating with their suppressive function. In this paper, we review the literature concerning the phenotype in mouse and in humans, showing that at least 2 subsets of MDSCs are present under different situations. We also address the role of MDSCs in tumor progression, evaluate the prognostic significance of MDSC in cancer patients, and their possible role as marker of clinical outcome and response to therapy. Finally, we examine the strategies designed to modulate MDSCs in cancer patients, which might represent an innovative approach to enhance the effectiveness of immune-based therapies.
Enones with strained double bonds. 2. The bicyclo[4.3.1]decane system (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEnones with strained double bonds. 2. The bicyclo[4.3.1]decane systemHerbert O. House and Thomas V. LeeCite this: J. Org. Chem. 1979, 44, 16, 2819–2824Publication Date (Print):August 1, 1979Publication History Published online1 May 2002Published inissue 1 August 1979https://pubs.acs.org/doi/10.1021/jo01330a001https://doi.org/10.1021/jo01330a001research-articleACS PublicationsRequest reuse permissionsArticle Views527Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Medicinal Leeches: Historical use, Ecology, Genetics and Conservation (2011)

After a short introduction to the classification of medicinal leeches, their historical use in phlebotomy (blood-letting) and contemporary use in neurobiology and medicine are summarised. Over-collecting of wild Hirudo medicinalis in Europe led to reduced populations and the need to import other species, especially the closely related Hirudo verbana from Turkey and, more recently, the Caribbean and Asian leech, Hirudinaria manillensis. The limited information on the quantitative ecology of European medicinal leeches is summarised next. They require warm-water ponds with a range of suitable hosts, especially amphibians, to survive and prosper. Medicinal leeches can persist with a low minimum viable population size, which may be typical of rare freshwater invertebrates in isolated habitats, especially species limited by high temperature requirements and specialised food sources. Phylogenetic relationships, using molecular methodology, show that there are at least two independent lineages of medicinal leeches with Hirudo medicinalis, H. verbana and Hirudinaria manillensis being closely related. The type species, H. medicinalis, was once abundant in Europe but is now rare and on the endangered list in several countries. Genetic studies have confirmed the erroneous marketing of H. verbana as H. medicinalis. It is highly probable that H. verbana has already escaped into the wild. Unlike H. medicinalis, H. verbana has no legal protection. We conclude that the major factor in the decline of medicinal leech populations has been the general loss of wetlands, especially eutrophic ponds and marshes throughout Europe. Destruction of these water bodies has also led to a decline in amphibians that are an important source of blood-meals for the leeches and are crucial for the survival of their juveniles. More quantitative information is required on H. medicinalis, and especially H. verbana, to facilitate their conservation and management, and to prevent them becoming extinct in the wild.