gebhart/patrepeval huggingface dataset:
Social Return on Investment Analysis of the Health Precinct Community Hub for Chronic Conditions (2020)

Local governments and Health Boards are seeking to develop integrated services to promote well-being. Social participation and physical activity are key in promoting well-being for older people. The Health Precinct is a community hub in North Wales that people with chronic conditions are referred to through social prescribing. To improve community-based assets there is a need to understand and evidence the social value they generate. Data collection took place October 2017-September 2019. Social Return on Investment (SROI) analysis was used to evaluate the Health Precinct. Stakeholders included participants aged 55+, participants' families, staff, the National Health Service and local government. Participants' health and well-being data were collected upon referral and four months later using the EQ-5D-5L, Campaign to End Loneliness Scale and the Rosenberg Self-Esteem Scale. Family members completed questionnaires at four months. Baseline data were collected for 159 participants. Follow-up data were available for 66 participants and 38 family members. The value of inputs was £55,389 (attendance fees, staffing, equipment, overheads), and the value of resulting benefits was £281,010; leading to a base case SROI ratio of £5.07 of social value generated for every £1 invested. Sensitivity analysis yielded estimates of between 2.60:1 and 5.16:1.
Building organizational commitment: A multifirm study (1990)

Although much research has been conducted in the area of organizational commitment, few studies have explicitly examined how organizations facilitate commitment among members. Using a sample of 291 respondents from 45 firms, the results of this study show that rigorous recruitment and selection procedures and a strong, clear organizational value system are associated with higher levels of employee commitment based on internalization and identification. Strong organizational career and reward systems are related to higher levels of instrumental or compliance‐based commitment.
Construction of Uracil and Tryptophan Auxotrophic Mutants from<i>Sake</i>Yeasts by Disruption of<i>URA3</i>and<i>TRP1</i>Genes (1990)

Uracil auxotrophic mutants were constructed from the sake yeasts K-701 and K-901 by successive URA3 gene disruption. First, as sake yeast is diploid, one URA3 gene was disrupted with pURA38 (AURA3 SMR1) and the heterozygous disruptant was isolated on an SM (sulfometuron methyl) plate. The other URA3 gene was disrupted with pURA36 (Δ URA3) and homozygous URA3 disruptants were isolated on FOA (5-fluoro-orotic acid) plate on which only ura3 mutants can grow. Direct URA3 gene disruption with pURA36 (Δ URA3) was also done and the uracil auxotrophic mutant was isolated. Four types of URA3 disruptants were isolated, two of which had no bacterial DNA. A tryptophan auxotrophic mutant was constructed from one of the URA3 disruptant using pTRP14 (Δ TRP1 URA3) by gene disruption. This TRP1 disruptant was also lacking bacterial DNA. Laboratory scale sake brewing using the auxotrophic mutants showed that these strains are very useful as recipient strains for molecular breeding of sake yeasts.
Electrospun La<sub>0.8</sub>Sr<sub>0.2</sub>MnO<sub>3</sub>nanofibers for a high-temperature electrochemical carbon monoxide sensor (2012)

Lanthanum strontium manganite (La(0.8)Sr(0.2)MnO(3), LSM) nanofibers have been synthesized by the electrospinning method. The electrospun nanofibers are intact without morphological and structural changes after annealing at 1050 °C. The LSM nanofibers are employed as the sensing electrode of an electrochemical sensor with yttria-stabilized zirconia (YSZ) electrolyte for carbon monoxide detection at high temperatures over 500 °C. The electrospun nanofibers form a porous network electrode, which provides a continuous pathway for charge transport. In addition, the nanofibers possess a higher specific surface area than conventional micron-sized powders. As a result, the nanofiber electrode exhibits a higher electromotive force and better electro-catalytic activity toward CO oxidation. Therefore, the sensor with the nanofiber electrode shows a higher sensitivity, lower limit of detection and faster response to CO than a sensor with a powder electrode.
Lateral position control of an electron channel in a split-gate device (1991)

A new mode of operation with a split-gate device has been studied theoretically. A simple model for quantitative description of the pinch-off voltage and channel position is proposed. Independent control of voltages applied to disconnected parts of a split gate enables the electron channel to be shifted laterally. The shift was calculated for both narrow and wide channels. The method can be used to study electron scatterers in the area defined by the slit in the gate.
Novel P2 Tris-tetrahydrofuran Group in Antiviral Compound<b>1</b>(GRL-0519) Fills the S2 Binding Pocket of Selected Mutants of HIV-1 Protease (2013)

GRL-0519 (1) is a potent antiviral inhibitor of HIV-1 protease (PR) possessing tris-tetrahydrofuran (tris-THF) at P2. The high resolution X-ray crystal structures of inhibitor 1 in complexes with single substitution mutants PR(R8Q), PR(D30N), PR(I50V), PR(I54M), and PR(V82A) were analyzed in relation to kinetic data. The smaller valine side chain in PR(I50V) eliminated hydrophobic interactions with inhibitor and the other subunit consistent with 60-fold worse inhibition. Asn30 in PR(D30N) showed altered interactions with neighboring residues and 18-fold worse inhibition. Mutations V82A and I54M showed compensating structural changes consistent with 6-7-fold lower inhibition. Gln8 in PR(R8Q) replaced the ionic interactions of wild type Arg8 with hydrogen bond interactions without changing the inhibition significantly. The carbonyl oxygen of Gly48 showed two alternative conformations in all structures likely due to the snug fit of the large tris-THF group in the S2 subsite in agreement with high antiviral efficacy of 1 on resistant virus.
Studies on the Synthesis of Insulin from Natural and Synthetic A and B Chains. I. Splitting of Insulin and Isolation of the S-Sulfonated Derivatives of the A and B Chains<sup>*</sup> (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudies on the Synthesis of Insulin from Natural and Synthetic A and B Chains. I. Splitting of Insulin and Isolation of the S-Sulfonated Derivatives of the A and B Chains*Panayotis G. Katsoyannis, Andrew Tometsko, Clyde Zalut, Stanley Johnson, and Anthony C. TrakatellisCite this: Biochemistry 1967, 6, 9, 2635–2642Publication Date (Print):September 1, 1967Publication History Published online1 May 2002Published inissue 1 September 1967https://pubs.acs.org/doi/10.1021/bi00861a001https://doi.org/10.1021/bi00861a001research-articleACS PublicationsRequest reuse permissionsArticle Views174Altmetric-Citations46LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Multicast routing considering reliability and network load in wireless ad-hoc network (2002)

Several multicast protocols have been newly proposed to perform multicast in wireless ad hoc networks. Tree based multicasting is fragile and requires frequent control to maintain multicast tree. Mesh based multicasting is reliable but increases network load by flooding through mesh. We propose a hybrid structure of tree and mesh for multicasting in wireless ad hoc networks. We assume that the system can predict the connection holding time between each upstream and downstream node by using the location and mobility information provided by GPS (Global Positioning System). The proposed scheme is more reliable than tree based scheme and reduces network load.
Tissue Regenerating Capacity of Carbodiimide-Crosslinked Dermal Sheep Collagen during Repair of the Abdominal Wall (1994)

In future, the function of collagen-based biomaterials as temporary scaffolds for the generation of new tissue may be emphasized. In this study the function of dermal sheep collagen (DSC) crosslinked with carbodiimide (ENDSC) as repair material for abdominal wall defects in rats was compared with that of commercial hexamethylenediisocyanate-crosslinked HDSC. The results indicate that early after implantation both ENDSC and HDSC functioned well as a matrix for cellular ingrowth. However during further implantation HDSC soon degraded resulting in herniations, while ENDSC showed a delay in the degradation time of at least 20 weeks. ENDSC thereby enabled collagen new-formation and functioned as a guidance for muscle overgrowth. These results are very promising concerning the problem of the ongoing foreign body reaction with continuing risk of implant rejection observed in clinical practice with non-degradable materials.
Radiation effects in gate-all-around structures (2002)

Gate-all-around (GAA) devices have been characterized by current vs. voltage techniques after being exposed to 10-keV X-rays under a variety of bias conditions. Parameters such as mobility, oxide trapped charge, interface state density, and leakage currents were monitored. The SIMOX (separation by implanted oxygen) GAA device, which has no buried-oxide back-gate, suffers no contribution from traditional back-gate interface effects. The interface state density, as determined from subthreshold slope stretch-out at a 1 Mrad(SiO/sub 2/) X-ray dose, indicates radiation induced D/sub it/ levels of low to mid 10/sup 11/ Hash /eV-cm/sup 2/ for the variety of bias conditions applied. The observed degradation in mobility and interface-state density is a function of the specific gate-oxide process used and not inherent to the GAA process.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Frequently-Used Properties of the Floor Function (2020)

The paper collects 42 frequently-used properties of the floor function, including 35 ones from other literatures and 7 newly added-and-proved ones. The collected properties cover basic inequalities, basic identities, conditional inequalities, conditional equalities and practical formulas. The paper is helpful for scholars of mathematics and computer science and technology in reading and writing scientific works, reasoning and designing algorithms.
Vital Staining in Fiberoptic Bronchoscopy (1986)

The authors report on the results obtained using vital staining in fiberoptic bronchoscopic investigations. Vital staining is performed during normal fiberoptic bronchoscopic investigations under local anesthesia. The method has proved very sensitive for cancerous and precancerous lesions of the bronchial mucosa.
A Scalable Architecture for MPEG-4 Wavelet Quantization (1999)

info:eu-repo/semantics/published
The Integrated Visual and Auditory Continuous Performance Test as a neuropsychological measure (2003)

The Integrated Visual and Auditory (IVA) Continuous Performance Test (CPT) and Neuropsychological Impairment Scale (NIS) were completed by adults diagnosed with mild traumatic brain injury (mTBI), adults diagnosed with attention deficit hyperactivity disorder (ADHD), and controls. On the IVA CPT, the mTBI and ADHD groups performed significantly lower on the full and secondary scales for attention and response accuracy. For individual scales, the mTBI and ADHD groups showed lower performance on measures of reaction time, inattention, impulsivity, and variability of RT. The mTBI and ADHD groups showed similar patterns of performance on the IVA. On the NIS, the mTBI and ADHD groups reported more neuropsychological symptoms than the control group, and the mTBI group reported more neuropsychological symptoms than the ADHD group. The results are discussed in regard to changes in cognitive processing and sustained attention in individuals diagnosed with mTBI and ADHD.
Use of molecular probes to detect human cytomegalovirus and human immunodeficiency virus. (1989)

Human cytomegalovirus (HCMV) and human immunodeficiency virus (HIV) cause severe disease. The identification of these viruses in clinical specimens and understanding the progression of infection and diseases relating to HCMV and HIV are essential to develop effective means for treatment and prevention. Here we describe the application of molecular probes to the diagnosis and pathogenesis of HCMV and HIV. In situ hybridization and the amplification procedure of polymerase chain reaction are used to detect both viruses; these techniques have provided important information regarding the pathogenesis of HCMV and HIV. A new technique, target cycling, may also prove useful for the detection of viruses by enriching for target sequences. The continued application of molecular probes to pathogenetic studies of HCMV and HIV promises to further our knowledge of these viruses, and of their interaction.
Effects of cocoa extract containing polyphenols and methylxanthines on biochemical parameters of obese‐diabetic rats (2008)

Abstract BACKGROUND: Previous studies have indicated that cocoa extract possesses hypoglycaemic and hypocholesterolaemic properties in streptozotocin‐induced diabetic rats. However, there has been limited research on the effects of cocoa extract on obese‐diabetic (Ob‐db) rats that mimic human diabetes syndrome. Hence this study was initiated to determine the effect of cocoa extract containing polyphenols and methylxanthines on several biochemical parameters, namely glucose level, insulin sensitivity and lipid profiles of Ob‐db rats. RESULTS: Intake of cocoa extract supplemented with polyphenols (2.17 mg epicatechin, 1.52 mg catechin, 0.25 mg dimer and 0.13 mg trimer g −1 cocoa extract) and methylxanthines (3.55 mg caffeine and 2.22 mg theobromine g −1 cocoa extract) for 4 weeks significantly ( P < 0.05) reduced the plasma total cholesterol, triglycerides and low‐density lipoprotein cholesterol of obese‐diabetic rats (Ob‐db + cocoa) compared with non‐supplemented animals (Ob‐db). Short‐term (acute) supplementation of cocoa extract significantly ( P < 0.05) reduced the plasma glucose level at 60 and 90 min compared with untreated rats as assessed by the oral glucose tolerance test. However, no significant differences were observed in plasma glucose level, insulin level and insulin sensitivity after chronic (4 weeks) cocoa extract supplementation. CONCLUSION: The results of this study suggest that cocoa extract possesses hypocholesterolaemic properties and can exert a transient glucose‐lowering effect but not long‐term glucose control. Copyright © 2008 Society of Chemical Industry
Appearance of Single-Crystalline Properties in Fine-Patterned Si Thin Film Transistors (TFTs) by Solid Phase Crystallization (SPC) (1993)

Uniformity of thin film transistor (TFT) characteristics was evaluated by varying the channel size. As channel length decreased and width fell below 1 µm, uniformity was degraded drastically. A few samples showed high-performance characteristics such as sharp gate voltage swing below 100 mV/dec and high mobility as high as 100 cm 2 /V·s near room temperature. Upon evaluation of their temperature dependence, the conduction mechanism showed not polycrystalline but single-crystal-like properties in the lattice scattering. The improved TFTs are thought to have been formed in grain boundary-free crystal grains.
Nanoimprinted plastic substrates for enhanced surface plasmon resonance imaging detection (2009)

Periodic nanostructures fabricated by Nanoimprint Litography (NIL) in low-cost plastic substrates and coated with thin gold film were explored for enhanced surface plasmon resonance imaging (SPRi) detection. Rigorous coupled-wave analysis was used to model the SPRi response of these nanostructured surfaces. Two-dimensional nanogratings and nanogrooves were fabricated on Zeonor 1060R(TM) by NIL and followed by metal deposition. The detection of refractive index changes in the dielectric layer due to bulk medium change, DNA immobilization and DNA hybridization events were monitored using SPRi to assess the corresponding signal amplification. The results indicate target-dependent sensitivity enhancement which is maximized for the detection of biomolecular binding events. The 500 nm period nanogrooves provided a 4 times SPR signal amplification compared to the conventional uniform gold film on SF-11 glass for DNA hybridization detection. Our work demonstrates that the use of nanoimprinted plastic substrates provides a low-cost solution for the SPR-based detection with sensitivity that meets the requirements in practical diagnostic applications.
Nuclear receptors rock around the clock (2014)

Circadian rhythms characterize almost every aspect of human physiology, endocrinology, xenobiotic detoxification, cell growth, and behavior. Modern lifestyles that disrupt our normal circadian rhythms are increasingly thought to contribute to various disease conditions ranging from depression and metabolic disorders to cancer. This self-sustained time-keeping system is generated and maintained by an endogenous molecular machine, the circadian clock, which is a transcriptional mechanism composed of the transcription factors CLOCK and BMAL and their co-repressors, PER and CRY. Nuclear receptors (NRs) represent a large family of hormone-sensitive transcriptional regulators involved in a myriad of biological processes such as development, energy metabolism, reproduction, inflammation, and tissue homeostasis. Recent studies point not only to NR regulation by the clock, but also to NR regulation of the clock itself. Here, we discuss recent studies that functionally and mechanistically implicate NRs as key components of both the universal and adaptive circadian clock mechanisms. As proven pharmacological targets, nuclear receptors are promising targets for therapeutic control of many pathological conditions associated with the disruption of circadian rhythm.
Sperm quality assessment via separation and sedimentation in a microfluidic device (2013)

A major reason for infertility is due to male factors, including the quality of spermatozoa, which is a primary factor and often difficult to assess, particularly the total sperm concentration and its motile percentage. This work presents a simple microfluidic device to assess sperm quality by quantifying both total and motile sperm counts. The key design feature of the microfluidic device is two channels separated by a permeative phase-guide structure, where one channel is filled with raw semen and the other with pure buffer. The semen sample was allowed to reach equilibrium in both chambers, whereas non-motile sperms remained in the original channel, and roughly half of the motile sperms would swim across the phase-guide barrier into the buffer channel. Sperms in each channel agglomerated into pellets after centrifugation, with the corresponding area representing total and motile sperm concentrations. Total sperm concentration up to 10(8) sperms per ml and motile percentage in the range of 10-70% were tested, encompassing the cutoff value of 40% stated by World Health Organization standards. Results from patient samples show compact and robust pellets after centrifugation. Comparison of total sperm concentration between the microfluidic device and the Makler chamber reveal they agree within 5% and show strong correlation, with a coefficient of determination of R(2) = 0.97. Motile sperm count between the microfluidic device and the Makler chamber agrees within 5%, with a coefficient of determination of R(2) = 0.84. Comparison of results from the Makler Chamber, sperm quality analyzer, and the microfluidic device revealed that results from the microfluidic device agree well with the Makler chamber. The sperm microfluidic chip analyzes both total and motile sperm concentrations in one spin, is accurate and easy to use, and should enable sperm quality analysis with ease.
Converting Unstructured System Logs into Structured Event List for Anomaly Detection (2018)

System logs provide invaluable resources for understanding system behavior and detecting anomalies on high performance computing (HPC) systems. As HPC systems continue to grow in both scale and complexity, the sheer volume of system logs and the complex interaction among system components make the traditional manual problem diagnosis and even automated line-by-line log analysis infeasible or ineffective. In this paper, we present a System Log Event Block Detection (SLEBD) framework that identifies groups of log messages that follow certain sequence but with variations, and explore these event blocks for event-based system behavior analysis and anomaly detection. Compared with the existing approaches that analyze system logs line by line, SLEBD is capable of characterizing system behavior and identifying intricate anomalies at a higher (i.e., event) level. We evaluate the performance of SLEBD by using syslogs collected from production supercomputers. Experimental results show that our framework and mechanisms can process streaming log messages, efficiently extract event blocks and effectively detect anomalies, which enables system administrators and monitoring tools to understand and process system events in real time. Additionally, we use the identified event blocks and explore deep learning algorithms to model and classify event sequences.
Synergistic Cytotoxicity of Recombinant Human TNF and Various Anti-Cancer Drugs (1988)

A synergistic increase in the cytotoxic effects of recombinant human tumor necrosis factor (rH-TNF) and anti-cancer drugs was demonstrated in vitro. The cytotoxicity of rH-TNF against L-M cells in combination with Mitomycin C (MMC), Adriamycin (ADM), Cytosine arabinoside (Ara-C), Actinomycin D (ACD), Daunomycin (DM), Cisplatin (CDDP), Vincristine (VCR), and 5-Fluorouracil (5FU), based on the concentration necessary for 50% inhibition of cell growth (IC50), was 4 to 347 times as high as that of rH-TNF alone. The results suggest that combination therapy including rH-TNF and anti-cancer drugs may be of value in the treatment of malignancy in human patients.