gebhart/patrepeval huggingface dataset:
A multi-dimensional spam filtering framework based on threat intelligence (2019)

Email remains the primary method used to initiate an advanced attack or deliver ransomware because it can be highly targeted and customized to increase the odds of exploitation. Most anti-spam technologies mitigate against traditional spam and viruses, but lack the automated analysis needed to catch spam campaigns and more dangerous threats from the first time they're seen. This paper proposes a new multidimensional spam filtering framework based on threat intelligence. The framework collaborates and classifies multiple mail filtering technologies, using threat intelligence mail data as a training set, combines static and dynamic analysis, threat intelligence analysis, and behavioral intention analysis to establish a multi-dimensional decision tree to identify and trace high-level email attacks.
Impact of Medium pH on DOX Toxicity toward HeLa and A498 Cell Lines (2020)

The influence of the pH of the multicomponent cell medium on the performance of doxorubicin (DOX), an anticancer drug, was studied on the examples of cervical (HeLa) and kidney (A498) cancer cell lines. The change of pH of the cell medium to more acidic led to a decrease of DOX toxicity on both cell lines due to the change of drug permeability across the cell membrane as a result of drug protonation. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) studies and lactate dehydrogenase (LDH) release tests have shown low toxicity of the drug, especially in the case of A498 cells, which are characterized by an extremely high glycolytic metabolism. The behavior was ascribed primarily to the increased proton concentration in the peripheral blood follicle in the presence of products of the acidic glycolytic metabolism. It is not observed in the measurements performed in commercially available media since they usually have a neutral pH. In earlier reports on kidney cancer, several mechanisms were discussed, including the metabolism of DOX to its less toxic derivative, doxorubicinol, overexpression of ATP binding cassette subfamily B member 1 (ABCB1) transporters, that remove DOX from the inside of cells; however, there was no focus on the simple but very important contribution of drug protonation described in the present study. Drug pH-dependent equilibria in the cell medium should be considered since changes in the drug form may be an additional reason for multidrug resistance.
High-efficiency, temperature-sensitive suppression of amber mutations in Escherichia coli. (1981)

We have constructed a high-copy-number plasmid carrying an allele of the supD gene (supD43,74). The plasmid conferred temperature-sensitive suppression of amber mutations. Strains carrying the plasmid exhibited 50 to 60% suppression at 30 degrees C but little or no suppression at 42 degrees C. After a temperature shift from 30 to 42 degrees C the efficiency of suppression decreased gradually over a 60- to 90-min period before reaching the 42 degrees C steady-state level of suppression.
Neural Hyperexcitability in Autism Spectrum Disorders (2017)

Despite the progress that has been made in research on autism spectrum disorders (ASD), the understanding of the biological basis of ASD to identify targets for novel, effective treatment remains limited. One of the leading biological theories of autism is a model of cortical hyperexcitability. While numerous genetic and epigenetic studies support this model, how this particular biological alteration relates to known phenotypes in ASD is not well established. Using examples of sensory processing alterations, this review illustrates how cortical excitability may affect neural processes to result eventually in some core clinical phenotypes in ASD. Applications of the cortical excitability model for translational research and drug development are also discussed.
Enantioselective Synthesis of (1<i>R</i>,2<i>S</i>)-1-Amino-2-vinylcyclopropanecarboxylic Acid Ethyl Ester (Vinyl-ACCA-OEt) by Asymmetric Phase-Transfer Catalyzed Cyclopropanation of (<i>E</i>)-<i>N</i>-Phenylmethyleneglycine Ethyl Ester (2010)

A concise asymmetric synthesis of (1R,2S)-1-amino-2-vinylcyclopropanecarboxylic acid ethyl ester, a key intermediate in the preparation of many hepatitis C virus inhibitors, is described. Stereoselective cyclopropanation of (E)-N-phenylmethyleneglycine ethyl ester was effected by treatment with trans-1,4-dibromo-2-butene in the presence of a catalytic amount of a chiral phase-transfer catalyst. Microscale high-throughput experimentation techniques were successfully used to identify a cinchonidine-derived catalyst that provided (1R,2S)-1-(E)-N-phenylmethyleneamino-2-vinylcyclopropanecarboxylic acid ethyl ester in up to 84% ee. This was translated to a lab scale process to attain 78% yield and 77.4% ee. Chiral purity upgrade and isolation of the ester was accomplished via preparatory supercritical fluid chromatography followed by crystallization of the ester as its tosylate salt. The improved synthesis described herein represents a potentially more economical preparation of this valuable intermediate.
Differential effects of natriuretic peptides and NO on LV function in heart failure and normal dogs (2001)

beta-Adrenergic hyporesponsiveness in congestive heart failure (CHF) is mediated, in part, by nitric oxide (NO). NO and brain natriuretic peptide (BNP) share cGMP as a second messenger. Left ventricular (LV) function and inotropic response to intravenous dobutamine (Dob) were assessed during sequential intracoronary infusion of saline, HS-142-1 (a BNP receptor antagonist), and HS-142-1 + N(G)-monomethyl-L-arginine (L-NMMA) in anesthetized dogs with CHF due to rapid pacing and in normal dogs during intracoronary infusion of saline, exogenous BNP, and sodium nitroprusside (SNP). In CHF dogs, intracoronary HS-142-1 did not alter the inotropic response to Dob [percent change in first derivative of LV pressure (% Delta dP/dt) 47 +/- 4% saline vs. 54 +/- 7% HS-142-1, P = not significant]. Addition of intracoronary L-NMMA to HS-142-1 enhanced the response to Dob (% Delta dP/dt 73 +/- 8% L-NMMA + HS-142-1, P < 0.05 vs. H142-1). In normal dogs, intracoronary SNP blunted the inotropic response to Dob (% Delta dP/dt 93 +/- 6% saline vs. 71 +/- 5% SNP, P < 0.05), whereas intracoronary BNP had no effect. In CHF dogs, the time constant of LV pressure decay during isovolumic relaxation increased with intracoronary HS-142-1 (48 +/- 4 ms saline vs. 58 +/- 5 ms HS-142-1, P < 0.05) and further increased with intracoronary L-NMMA (56 +/- 6 ms HS-142-1 vs. 66 +/- 7 ms L-NMMA + HS-142-1, P < 0.05). Endogenous BNP and NO preserve diastolic function in CHF, whereas NO but not BNP inhibits beta-adrenergic responsiveness.
Optimal des'ign of Power System Stabilizers Using Particle Swarm Opt'imization (2002)

In this paper, a novel evolutionary algorithm-based approach to optimal design of multimachine power system stabilizers (PSSs) is proposed. The proposed approach employs the particle swarm optimization (PSO) technique to search for optimal settings of PSS parameters. Two elgenvalue-based objective functions to enhance system damping of electromechanical modes are considered. The robustness of the proposed approach to the initial guess is demonstrated. The performance of the proposed PSO-based PSS (PSOPSS) under different disturbances, loading conditions, and system configurations is tested and examined for different multimachine power systems. Eigenvalue analysis and nonlinear simulation results show the effectiveness of the proposed PSOPSSs to damp out the local as well as the interarea modes of oscillations and work effectively over a wide range of loading conditions and system configurations. In addition, the potential and superiority of the proposed approach over the conventional approaches are demonstrated.
The role of surface tension of spreading droplets in absorption of a herbicide formulation via leaf stomata (1993)

Abstract The foliar absorption by field bean ( Vicia fabu L.) of triclopyr‐triethylamine from solutions containing an organosilicone surfactant, ‚Silwet L‐77’︁ at 0, 1.0, 2.5 and 5.0 ml litre −1 , was investigated using fluorescence and radiotracer studies. Physical characteristics such as formulation surface tension and contact angles of droplet formed on the field bean leaf were determined and combined to obtain a critical surface tension value (γ critical ) of 19.5–22.9 mN m −1 for the adaxial leaf surface. The apparent surface tensions of the three formulations containing L‐77 were equivalent and low, an average of 22 mN m −1 , which would be sufficiently low to permit stomatal infiltration. The presence of L‐77 at 2.5 or 5.0 ml litre −1 significantly enhanced the uptake of triclopyr‐triethylamine into the leaf, particularly via stomatal pore regions. However, stomatal uptake from solutions containing 0 or 1.0 ml litre −1 L‐77 was limited or non‐existent. A phenomenon termed ‚adsorptive dilution’︁ is proposed to explain the absence of stomatal infiltration with the 1.0 ml litre −1 formulation. This involves a migration of surfactant from the bulk solution to the expanding droplet surfaces as the droplet spreads. This dilutes the surfactant concentration within the bulk solution, which can in turn increase surface tension.
MR imaging of patients with implanted drug infusion pumps (1991)

The influence of magnetic resonance (MR) imaging on the integrity and function of an implantable, programmable drug infusion pump and the distortion of the image by this device were tested. Six identical pumps were tested in magnetic fields of 1.5 T. Pump memory was not affected by the procedure. The pump rotor stalled (no infusion) as long as the device was within the magnetic field. Drug delivery resumed as programmed after the pump was removed from the field. No structural damage to the electrical or mechanical pump components was detected. The pump caused a circular image artifact (a signal dropout) within 8-10 cm of the device. The authors conclude that MR imaging is accurate if the area of interest is at least 10 cm from the pump, and that with awareness of temporary infusion cessation, it is safe to perform MR imaging in patients with this implanted pump.
Properties of Signature Change Patterns (2006)

Understanding function signature change properties and evolution patterns is important for researchers concerned with alleviating signature change impacts, understanding software evolution, and predicting future evolution patterns. We provide detailed signature change properties by analyzing seven software project histories to reveal multiple properties of signature changes, including their kind, frequency, correlation with other changes, number of parameter changes, and evolution patterns of signature change kinds. We show that signature changes can be used as measurement aid for software evolution analysis
Dynamic Prefix Tree for Service Discovery within Large Scale Grids (2006)

Within computational grids, some services (software components, linear algebra libraries, etc.) are made available by some servers to some clients. In spite of the growing popularity of such grids, the service discovery, although efficient in many cases, does not reach several requirements. Among them, the flexibility of the discovery and its efficiency on wide-area dynamic platforms are two major issues. Therefore, it becomes crucial to propose new tools coping with such platforms. Emerging peer-to-peer technologies provide algorithms allowing the distribution and the retrieval of data items while addressing the dynamicity of the underlying network. We study in this paper the service discovery in a pure peer-to-peer environment. We describe a new trie-based approach for the service discovery that supports range queries and automatic completion of partial search strings, while providing fault-tolerance, and partially taking into account the topology of the underlying network. We validate this approach both by analysis and simulation. Traditional metrics considered in peer-to-peer systems exhibits interesting complexities within our architecture. The analysis' results are confirmed by some simulation experiments run using several grid's data sets
S-matrix oriented CAD-tool for simulating complex integrated optical circuits (1996)

A design tool for simulation of complex integrated optical circuits, based on a professional microwave design system has been developed. Implementation of a number of components is described and a simulation example of an add-drop node using a 4/spl times/4 phased array is presented.
Fabrication of gold nanoparticle–polymer composite particles with raspberry, core–shell and amorphous morphologies at room temperature via electrostatic interactions and diffusion (2013)

Composite particles with varying morphologies composed of gold nanoparticles (Au NPs) and polymers were fabricated based on a combination of electrostatic interactions between the polymer particles and Au NPs and diffusion processes. The positively charged polymer particles were prepared from amino-terminated polystyrene (PS-NH2) and amino-terminated 1,2-polybutadiene (PB-NH2). Adsorption of citrate-stabilized Au NPs resulted in three different distribution states of Au NPs in the polymer particles, depending on the glass transition temperature (Tg) and molecular weight of the polymer. The adsorption of Au NPs onto PS-NH2 particles produced raspberry-like composite particle morphologies, while the NPs instead diffused into the PB-NH2 particles, since the Tg of PB-NH2 is below room temperature. The diffusion of Au NPs could be controlled by varying the molecular weight of the PB-NH2 and the diameter of the NPs, and both core-shell and amorphous distributions were successfully achieved.
A New Compression Based Index Structure for Efficient Information Retrieval (2012)

Finding desired information from large data set is a difficult problem. Information retrieval is concerned with the structure, analysis, organization, storage, searching, and retrieval of information. Index is the main constituent of an IR system. Now a day exponential growth of information makes the index structure large enough affecting the IR system’s quality. So compressing the Index structure is our main contribution in this paper. We compressed the document number in inverted file entries using a new coding technique based on run-length encoding. Our coding mechanism uses a specified code which acts over run-length coding. We experimented and found that our coding mechanism on an average compresses 67.34 % more than the other techniques.
Deformation of organic matter and its effect on pores in mud rocks (2020)

Pores within organic matter (OM) are strongly linked to hydrocarbon generation and primary migration in fine-grained source rocks and are very important for evaluating hydrocarbon storage and flow in shale reservoirs. Thus, it is critical to clarify the features of OM-hosted pores and their evolution in organic-rich mud rocks. The OM in mud rocks, including kerogen and bitumen, is deformed when the original equilibrium stress conditions are altered. The OM deformation at the nano- or microscale has rarely been discussed because of the lack of unequivocal evidence. This research begins with examining the subsurface evolution of kerogen and bitumen, with emphasis on various features of pores hosted by bitumen. Evidence of OM deformation is documented in scanning electron microscope images of seven overmature samples from the lower Silurian Longmaxi Shale, Sichuan Basin. To aid in the understanding and analysis, OM deformation is classified into three types: type I deformation induced by one additional force, type II deformation induced by two additional forces acting on two locations of single OM particles, and type III deformation induced by three or more deforming forces acting at three or more locations of single OM particles. Thus, type I deformation is generally less complex than type II and III deformation. The OM particles subjected to type I deformation were analyzed quantitatively for parameters such as pore size, geometry, and long-axis orientation of elliptical pores. Deformation of OM enhances the robust heterogeneity of OM-hosted pores.
Supramolecular Donor−Acceptor Heterojunctions by Vectorial Stepwise Assembly of Porphyrins and Coordination-Bonded Fullerene Arrays for Photocurrent Generation (2009)

A novel strategy for constructing a vertical arrangement of bicontinuous donor-acceptor arrays on a semiconducting electrode has been developed. The relationship between the film structure and the photoelectrochemical properties has been elucidated as a function of the number of donor layers for the first time. The maximum incident photon-to-current efficiency value (21%) is comparable to the highest value (20%) reported for vertical arrangements of bicontinuous donor-acceptor arrays on electrodes.
Optimization of Quartz SAW Resonator Structure with Groove Gratings (1982)

Abstruct-A new surface acoustic wave (SAW) resonator optimum design method is proposed to reduce resonator sue. The fundamental design feature is optimization of the interdigital transducer (IDT) electrode period to reflector electrode period ratio, in order to adjust the frequency for the maximum IDT admittance to the maximum reflector reflection point. As a result of the optimized electrode period ratio, both reflector and IDT frequency responses are utilized to advantage, and good resonant Characteristics are obtained with a reduced number of reflector electrode fingers. This design method can be effectively applied for SAW resonators with groove gratings, both on reflectors and transducer, that are formed by a reactive sputter etching process. 145 MHz SAW resonators with groove gratings fabricated on a small 6 mm X 3 mm ST-cut quartz chip have provided good electrical performances, such as high Q values above 2 X lo4 and low resonance resistance in the 20-30 range.
High-Performance Corrosion-Resistant Iron-Based Amorphous Metals - The Effects of Composition, Structure and Environment: Fe49.7Cr17.7Mn1.9Mo7.4W1.6B15.2C3.8Si2.4 (2006)

Several Fe-based amorphous metal formulations have been identified that appear to have corrosion resistance comparable to (or better than) that of Ni-based Alloy C-22 (UNS No. N06022), based on measurements of breakdown potential and corrosion rate in seawater. Both chromium (Cr) and molybdenum (Mo) provide corrosion resistance, boron (B) enables glass formation, and rare earths such as yttrium (Y) lower critical cooling rate (CCR). SAM2X5 (Fe{sub 49.7}Cr{sub 17.7}Mn{sub 1.9}Mo{sub 7.4}W{sub 1.6}B{sub 15.2}C{sub 3.8}Si{sub 2.4}) has no yttrium, and is characterized by relatively high critical cooling rates of approximately 600 Kelvin per second. Data for the SAM2X5 formulation is reported here. In contrast to yttrium-containing iron-based amorphous metals, SAM2X5 can be readily gas atomized to produce spherical powders which enable more facile thermal spray deposition. The reference material, nickel-based Alloy C-22, is an outstanding corrosion-resistant engineering material. Even so, crevice corrosion has been observed with C-22 in hot sodium chloride environments without buffer or inhibitor. SAM2X5 also experiences crevice corrosion under sufficiently harsh conditions. Both Alloy C-22 and Type 316L stainless lose their resistance to corrosion during thermal spraying, due to the formation of deleterious intermetallic phases which depletes the matrix of key alloy elements, whereas SAM2X5 can be applied as coatings with the same corrosion resistance as a fully-dense completely amorphous melt-spun ribbon, provided that its amorphous nature is preserved during thermal spraying. The hardness of Type 316L Stainless Steel is approximately 150 VHN, that of Alloy C-22 is approximately 250 VHN, and that of HVOF SAM2X5 ranges from 1100-1300 VHN [MRS12-13]. Such hardness makes these materials particularly attractive for applications where corrosion-erosion and wear are also issues. Since SAM2X5 has high boron content, it can absorb neutrons efficiently, and may therefore find useful applications as a criticality control material within the nuclear industry.
Understanding radio polarimetry. III. Interpreting the IAU/IEEE definitions of the Stokes parameters (1996)

In two companion papers (Paper I, Hamaker et al. 1996; Paper II, Sault et al. 1996), a new theory of radio-interferometric polarimetry and its application to the calibration of interferometer arrays are presented. To complete our study of radio polarimetry, we examine here the definition of the Stokes parameters adopted by Commission 40 of the IAU (1974) and the way this definition works out in the mathematical equations. Using the formalism of Paper I, we give a simplified derivation of the frequently-cited `black-box' formula originally derived by Morris et al. (1964). We show that their original version is in error in the sign of Stokes V, the correct sign being that given by Weiler (1973) and Thompson et al. (1986).
Fixed reference frame phase-locked loop (FRF-PLL) for unbalanced line voltage conditions (2008)

In this work a phase-locked loop (PLL) is presented, which is able to provide an estimation of the angular frequency, and both the positive and negative sequences of the fundamental component of a three-phase signal. These sequences are provided in fixed reference frame coordinates, and thus the proposed algorithm is referred as fixed reference frame PLL (FRF-PLL). In fact, the FRF-PLL does not require transformation of variables into the synchronous frame coordinates as in most PLL schemes. The design of the FRF-PLL is based on a complete description of the source voltage involving both positive and negative sequences in stationary coordinates and considering the angular frequency as an uncertain parameter. Therefore, the FRF-PLL is intended to perform properly under severe unbalanced conditions, and to be robust against angular frequency variations in the three-phase source voltage signal. Although not considered in the design, it is shown that the scheme is also robust against harmonic distortion present in the source voltage signal.
Structural characterization of an elevated lipid bilayer obtained by stepwise functionalization of a self-assembled alkenyl silane film (2007)

This work reports a novel tethered lipid membrane supported on silicon oxide providing an improved model cell membrane. There is an increasing need for robust solid supported fluid model membranes that can be easily deposited on soft cushions. In such architecture the space between the membrane and the substrate should be tunable in the nanometer range. For this purpose a SiO(2) surface was functionalized with poly(ethylene glycol) (PEG)-lipid tethers and further modified with poly(ethylene glycol) making a biologically passivated substrate available for lipid bilayer deposition. First, a short chain self-assembled alkenyl silane film was oxidized to yield terminal COOH groups and then functionalized with amino-terminated PEG-lipids via N-hydroxysuccinimide chemistry. The functionalized silane film was then additionally passivated by functionalization of unreacted COOH groups with amino-terminated PEG of variable chain length. X-ray photoelectron spectroscopy (XPS) analysis of dry films, carried out near the C 1s ionization edge to characterize chemical groups formed in the near-surface region, confirmed binding of PEG-lipid tethers to the silane film. XPS further indicated that backfilling with PEG caused the lipid tails to stick up above the PEG layer which was confirmed by the x-ray reflectivity measurements. Lipid vesicle fusion on these surfaces in the presence of excess water resulted in the formation of supported membranes characterized by very high homogeneity and long range mobility, as confirmed by fluorescence bleaching experiments. Even after repeated drying-hydrating cycles, these robust surfaces provided good templates for high fluidity elevated membranes. X-ray reflectivity measurements of the tethered membranes, with a resolution of 0.6 nm in water, showed that these fluid membranes are elevated up to 8 nm above the silicon oxide surface.