gebhart/patrepeval huggingface dataset:
Kefir Peptides Prevent Hyperlipidemia and Obesity in High‐Fat‐Diet‐Induced Obese Rats via Lipid Metabolism Modulation (2017)

Scope Obesity has reached epidemic proportions worldwide. Obesity is a complex metabolic disorder that is linked to numerous serious health complications with high morbidity. The present study evaluated the effects of kefir peptides on high fat diet (HFD)‐induced obesity in rats. Methods and results Kefir peptides markedly improved obesity, including body weight gain, inflammatory reactions and the formation of adipose tissue fat deposits around the epididymis and kidney, and adipocyte size. Treating high fat diet (HFD)‐induced obese rats with kefir peptides significantly reduced the fatty acid synthase protein and increased the p‐acetyl‐CoA carboxylase protein to block lipogenesis in the livers. Kefir peptides also increased fatty acid oxidation by increasing the protein expressions of phosphorylated AMP‐activated protein kinase, peroxisome proliferator‐activated receptor‐α, and hepatic carnitine palmitoyltransferase‐1 in the livers. In addition, administration of kefir peptides significantly decreased the inflammatory response ( TNF‐α , IL‐1β , and TGF‐β ) to modulate oxidative damage. Conclusion These results demonstrate that kefir peptides treatment improves obesity via inhibition of lipogenesis, modulation of oxidative damage, and stimulation of lipid oxidation. Therefore, kefir peptides may act as an anti‐obesity agent to prevent body fat accumulation and obesity‐related metabolic diseases.
Storing Owl Ontologies In Sql Relational Databases (2007)

Relational databases are often used as a basis for persistent storage of ontologies to facilitate rapid operations such as search and retrieval, and to utilize the benefits of relational databases management systems such as transaction management, security and integrity control. On the other hand, there appear more and more OWL files that contain ontologies. Therefore, this paper proposes to extract ontologies from OWL files and then store them in relational databases. A prerequisite for this storing is transformation of ontologies to relational databases, which is the purpose of this paper.
ON THE COLLISION DETECTION PROBLEM FOR ROBOT MANIPULATORS (1995)

Abstract This paper presents a straightforward method for collision detection involving robot manipulators in three dimensions. Two types of collision are considered, the first occurring among multiple robot manipulators and the second occurring between robot manipulators and objects in the workspace. The methods are based on determining the distances between two robot manipulators or between a robot manipulator and an object, using approximate models of both the robot manipulators and the objects.
Optimization of Properties of Planar Spiral Inductors (2007)

This paper deals with investigation of properties of planar spiral inductors realized by application of thick film process. Various implementations of the thick-film planar spiral inductors can be considered. Various film processes were used for fabrication such as screen printing, direct writing and ultrasonic wire bonding and its combinations. Some of projected patterns of the inductors were fabricated and its electrical properties were measured. The results are discussed. Generally, the background of this work was to find out the optimal thick film technique and structure of thick film planar inductor, which can be applicable to construct the thick film transformer. The considered transformer could replace the PCB solutions, in some applications.
Carbon Epoxy Perforated Skin for Nacelle Acoustic Treatment (1990)

<div class="htmlview paragraph">The acoustic treatment requirement for jet engine nacelle inner flowpath leads to using perforated skin.</div> <div class="htmlview paragraph">Formerly in light alloy these skins are now composite and new techniques have been developped to achieve the perforation.</div> <div class="htmlview paragraph">After reviewing different possible techniques (mandrel tool, abrasion, stamping, mechanical drilling,…) one process is chosen and described in terms of skin mechanical properties, cost, and production facilities.</div>
Clinical Varieties of Neuromuscular Disease in Debrancher Deficiency (1984)

Two men and one woman with debrancher deficiency had symptoms and signs of neuromuscular disease. The two men had adult-onset and slowly progressive weakness, distal muscle wasting, "mixed" electromyographic patterns, and slow nerve conduction velocities; the initial diagnosis was Charcot-Marie-Tooth disease in one patient and motor neuron disease in the other. The woman had stunted growth, delayed motor milestones, and lifelong nonprogressive weakness. A muscle biopsy specimen showed severe vacuolar myopathy in all three cases. The glycogen concentration was increased threefold to sixfold and had an abnormal iodine spectrum. Anaerobic glycolysis in vitro showed impaired use of endogenous and exogenous glycogen but normal use of hexose-phosphate glycolytic intermediates. These three cases illustrated the clinical variety of neuromuscular disease in debrancher deficiency. In patients with weakness of adult onset, the diagnosis is impossible to make without performing a muscle biopsy.
Changes in bronchial reactivity to acetylcholine with type C influenza virus infection in dogs. (1986)

To investigate the mechanisms involved in increasing bronchial reactivity, we made a model of airway reactivity increase in dogs after Type C influenza virus infection. Five beagle dogs were inoculated intranasally with the virus, and the time courses of changes in the hemagglutination inhibition (HI) antibody titer and the bronchial reactivity were determined. To assess bronchial reactivity the dogs were anesthetized, and dose-response curves of pulmonary resistance were obtained against increasing concentrations of acetylcholine aerosol. The dogs infected with the virus showed mild symptoms of rhinorrhea and cough. The HI antibody titer was significantly increased in all dogs, with peak values at 1 to 3 wk after infection. The bronchial reactivity to acetylcholine began to increase towards Day 3, reached a peak at 1 to 2 wk, and returned to a normal level at 4 wk. The airway reactivity to acetylcholine at 2 wk after infection was increased by 2.3 to 6.5 times the normal value in terms of the acetylcholine provocative concentration. The mean increase was significant at 1 wk (p less than 0.05), 2 wk (p less than 0.01), and 3 wk (p less than 0.05). Although both the HI antibody titer and the airway responsiveness increased together towards 1 to 2 wk, no close relationship between these factors was observed thereafter. The present dog model of airway hyperreactivity may be useful for further investigation of the mechanism governing increase in bronchial reactivity with respiratory viral infection in normal subjects as well as in patients with asthma.
Arginase: an emerging key player in the mammalian immune system (2009)

The enzyme arginase metabolizes L-arginine to L-ornithine and urea. Besides its fundamental role in the hepatic urea cycle, arginase is also expressed the immune system of mice and man. While significant interspecies differences exist regarding expression, subcellular localization and regulation of immune cell arginase, associated pathways of immunopathology are comparable between species. Arginase is induced in murine myeloid cells mainly by Th2 cytokines and inflammatory agents and participates in a variety of inflammatory diseases by down-regulation of nitric oxide synthesis, induction of fibrosis and tissue regeneration. In humans, arginase I is constitutively expressed in polymorphonuclear neutrophils and is liberated during inflammation. Myeloid cell arginase-mediated L-arginine depletion profoundly suppresses T cell immune responses and this has emerged as a fundamental mechanism of inflammation-associated immunosuppression. Pharmacological interference with L-arginine metabolism is a novel promising strategy in the treatment of cancer, autoimmunity or unwanted immune deviation.
oldermenswellbeing.co.uk (2013)

What connects Brighton and Hove Albion Football Club, HMP Preston and the Merseyside Men’s Barbershop Chorus?
Fabrication of Discrete Materials by Interface-Selective Sol-Gel Polymerization (2002)

Abstract Self-hydrolyzing inorganic precursors underwent interface selective sol-gel polymerization at different interfaces between water and templates. This interface sol-gel polymerization was applied to fabricating discrete materials by encapsulating various materials with silica, titania, iron oxide and alumina.
A Naphthalene-Fused Tricyclic Orthoamide (1995)

The crystal structure of 3a,6a,12b-triaza-1,2,3,3a,4,5,6,6a,12b,12c-decahydroperylene, C 17 H 19 N 3 , (6), shows that the naphthalene unit adopts an orientation orthogonal to the average plane of the triaza-trans-decalin moiety. This forces two aromatic N-atom lone pairs to orient equatorially and thus allows only partial overlap with the naphthalene π system.
HIGH EFFICIENCY GENETIC MODIFICATION OF UNSTIMULATED PRIMARY CD8 AND CD34 CELLS USING ADENO-ASSOCIATED VIRUS PLASMID LIPOSOME COMPLEXES (1994)

Lebkowski, Jane S.; Brunette, Elisa; Kilinski, Lydia; Murugesh, Deepa; Berson, Amy E.; Philip, Mohan; Okarma, Thomas B.; Philip, Ramila Author Information
Palladium-Catalyzed Regioselective Alkynylation of Pyrroles and Azoles under Mild Conditions: Application to the Synthesis of a Dopamine D-4 Receptor Agonist (2015)

A mild and general method for the direct alkynylation of azoles such as pyrrole, indole, and 7-azaindole is described here. Using a simple catalytic system such as Pd(OAc)2 (2.5 mol %), P(tBu)2Me·HBF4 (5 mol %), and NaOAc (2 equiv) allowed the regioselective introduction of various alkynyl residues at the C-2 position of pyrroles. Interestingly, C-2 alkynylation was also observed on C-3-substituted indoles, whereas classical C-3 alkynylation was obtained on selected unsubstituted indoles and 7-azaindole. Our methodology has been illustrated by the efficient synthesis of a potential schizophrenia drug (dopamine D-4 inhibitor).
Surface-enhanced resonance Raman and electrochemical investigation of glucose oxidase catalysis at a silver electrode (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSurface-enhanced resonance Raman and electrochemical investigation of glucose oxidase catalysis at a silver electrodeRandall E. Holt and Therese M. CottonCite this: J. Am. Chem. Soc. 1989, 111, 8, 2815–2821Publication Date (Print):April 1, 1989Publication History Published online1 May 2002Published inissue 1 April 1989https://pubs.acs.org/doi/10.1021/ja00190a012https://doi.org/10.1021/ja00190a012research-articleACS PublicationsRequest reuse permissionsArticle Views579Altmetric-Citations72LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
New Plasma Separation Glucose Oxidase-based Glucometer in Monitoring of Blood With Different PO2 Levels (2011)

The PalmLab glucometer provides accurate results in samples with high PO(2) and is suitable for measuring arterial glucose levels in pediatric patients.
High Density Recording Technology (2005)

Two new recording technologies, land and groove recording and mark edge recording, have been developed to achieve the largecapacity phase-change rewritable disk. As a result , high-density recording has been made possible at track pitch 0.74 pm and bit length 0.41 pmhit. These technologies can realize a broad margin for radial tilt and adjacent track erasing.
Nonlinear System Analysis and Identification from Random Data (1991)

Linear Systems, Random Data, Spectra Zero-Memory Nonlinear Systems Bilinear and Trilinear Systems Nonlinear System Input/Output Relationships Square-Law and Cubic Nonlinear Systems Statistical Errors in Nonlinear Estimates Parallel Linear and Nonlinear Systems.
The HDF, The Arizona View (1999)

We present an initial analysis of the star formation rates in the deep NICMOS field of the Hubble Deep Field. The analysis utilizes template photometric redshift and extinction techniques on the combination of six optical and near infrared fluxes available for this region from\nobservations with both NICMOS and WFPC2. Our results are consistent with a constant star formation rate for a redshift range of 1 to 6.
Probed determination of turn-on spread of large area thyristors (1966)

Thyristors (SCR's) were specially constructed to permit the direct observation of the lateral spread of turn-on within the device. The effects on the spread of turn-on of the load current, basewidths, temperature, anode-cathode voltage, gate control pulse, and a large inhomogeneity were observed. The spreading velocity of the on-state and the load current are related approximately by the expression <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">V^{n} \propto I</tex> at high load currents. The spreading velocity is higher in devices with narrower basewidths and increases with temperature. Neither the anode-cathode voltage before turn-on nor the gate control pulse affect the spreading velocity of the on-state. Measurements on end gate devices and center gate linear devices show that triggering at the center enables an equivalent area of the SCR to turn on in less time than occurs when triggering at the end. A large gap in the emitter layer will delay the spread of the on-state but will not necessarily stop the spreading.
Electric current enhanced defect mobility in Ni3Ti intermetallics (2004)

The effect of the application of a dc current on the annealing of point defects in Ni3Ti was investigated by positron annihilation spectroscopy. An increased defect annealing rate was observed under the influence of the current and was attributed to a 24% decrease in the activation energy of mobility. The results are interpreted in terms of the electron wind effect and the complex nature of diffusion in ordered intermetallic phases. They provide direct evidence for an increase in defect mobility in ordered intermetallics under the influence of a current.
Physical Access Control Based on QR Code (2011)

Nowadays, the authentication methods of physical access control such as key, smart card, and OTP (One Time Password) card require extra hardware, and it is not easy to be aware of if they are lost because of the low using rate. Nowadays, mobile phone is one of the most common used and carry-on device. It would be detected in a shorter time when a mobile phone is lost because it was frequently used in daily time. One of the advantage of OTP is that it is only used once and it is securer compared to the fixed password. QR code is a kind of two-dimension matrix code, which has high encryption and decryption speed; it can not only store large information but also has the error-correction ability. In this paper, we try to develop a safe and efficient authentication way by using mobile phone and implement it for access control system. We take the advantage of one-time usage by using OTP, and store the secret information into QR code. Therefore, the proposed system enhances the security of physical access control systems.
An exploration of document impact on graph-based multi-document summarization (2008)

The graph-based ranking algorithm has been recently exploited for multi-document summarization by making only use of the sentence-to-sentence relationships in the documents, under the assumption that all the sentences are indistinguishable.However, given a document set to be summarized, different documents are usually not equally important, and moreover, different sentences in a specific document are usually differently important.This paper aims to explore document impact on summarization performance.We propose a document-based graph model to incorporate the document-level information and the sentence-to-document relationship into the graph-based ranking process.Various methods are employed to evaluate the two factors.Experimental results on the DUC2001 and DUC2002 datasets demonstrate that the good effectiveness of the proposed model.Moreover, the results show the robustness of the proposed model.
Automatic sleep-wake stages classifier based on ECG (2009)

Sleep-wake stages discrimination is an important task in the study of cardiorespiratory diseases. Usually this is done by processing physiological signals such as electroencephalogram (EEG) that are, exclusively, recorded in hospitals using polysomnography (PSG) systems. In this paper, we report a simple automatic sleep-wake stages classifier using only RR series obtained from electrocardiogram (ECG). Seven features were extracted from the RR series by three methods, the heart rate variability (HRV), the detrended fluctuation analysis (DFA) and a proposed windowed detrended fluctuation analysis (WDFA). A subject-specific scheme was used where 20% of a subject's data was used to train the classifier and 80% for the classification. The method was tested on the MIT/BIH Polysomnographic Database (MITBPD) using support vector machine (SVM). Finally, the sleep efficiency S eff was calculated for evaluation of sleep condition.
Supporting the creation of dynamic, interactive virtual environments (2007)

Virtual Reality's expanding adoption makes the creation of more interesting dynamic, interactive environments necessary in order to meet the expectations of users accustomed to modern computer games. In this paper, we present initial explorations of using the recently developed Functional Reactive Programming paradigm to support the creation of such environments. The Functional Reactive Programming paradigm supports these actions by providing tools that match both the user's perception of the dynamics of the world and the underlying hybrid nature of such environments. Continuous functions with explicit time dependencies describe the dynamic behaviors of the environment and discrete event mechanisms provide for modifying the active behaviors of the environment. Initial examples show how this paradigm can be used to control dynamic, interactive Virtual Environments.
IL-4 and IL-13 regulation of ICAM-1 expression and eosinophil recruitment in Onchocerca volvulus keratitis. (2002)

These findings demonstrate that expression of ICAM-1 and recruitment of eosinophils to the cornea are tightly regulated by IL-4 and IL-13, and indicate that these cytokines are a potential target for immune intervention in ocular allergy and parasitic infections of the eye.
Ultrasmooth Gold Surfaces Prepared by Chemical Mechanical Polishing for Applications in Nanoscience (2014)

For over 20 years, template stripping has been the best method for preparing ultrasmooth metal surfaces for studies of nanostructures. However, the organic adhesives used in the template stripping method are incompatible with many solvents, limiting the conditions that may subsequently be used to prepare samples; in addition, the film areas that can be reliably prepared are typically limited to ∼1 cm(2). In this article, we present chemical-mechanical polishing (CMP) as an adhesive-free, scalable method of preparing ultrasmooth gold surfaces. In this process, a gold film is first deposited by e-beam evaporation onto a 76-mm-diameter silicon wafer. The CMP process removes ∼4 nm of gold from the tops of the grains comprising the gold film to produce an ultrasmooth gold surface supported on the silicon wafer. We measured root-mean-square (RMS) roughness values using atomic force microscopy of 12 randomly sampled 1 μm × 1 μm areas on the surface of the wafer and repeated the process on 5 different CMP wafers. The average RMS roughness was 3.8 ± 0.5 Å, which is comparable to measured values for template-stripped gold (3.7 ± 0.5 Å). We also compared the use of CMP and template-stripped gold as bottom electrical contacts in molecular electronic junctions formed from n-alkanethiolate self-assembled monolayers as a sensitive test bed to detect differences in the topography of the gold surfaces. We demonstrate that these substrates produce statistically indistinguishable values for the tunneling decay coefficient β, which is highly sensitive to the gold surface topography.
Effect of „Living High-Training Low” on the Cardiac Functions at Sea Level (1998)

Living high-training low (LHTL), living at high altitude and training at sea level, is reported to be beneficial in enhancing physical performance. Effect of LHTL on cardiac function which is one of major determinants in performance, however, was not examined. To address this issue, 21 well-trained triathletes divided into control (n = 10, living and training at sea level) and LHTL group (living at 1980 m altitude > or = 12 hrs/day and training at sea level) were Doppler echocardiographically examined before and at the end of the two-week program. Heart rate and blood pressure did not change in both groups. At end of the training, left ventricular endsystolic diameter of LHTL group was smaller than that of controls (32 vs 34 mm, P < 0.05). Shortening fraction and ejection fraction in LHTL group increased by 9% and 17 %, respectively, P < 0.05. Preejection period/ejection time was more greatly reduced in LHTL group (P < 0.05). Stroke volume and cardiac output in LHTL increased. Diastolic function was not significantly affected by LHTL. These results suggest that LHTL produced an improvement of systolic function underlined by incremented left ventricular contractility, which might be associated with increased beta-adrenergic receptor or an improved myocardial energy utilization.
Yeast targets for mRNA methylation (2010)

N(6)-Methyladenosine (m(6)A) is a modified base present in the mRNA of all higher eukaryotes and in Saccharomyces cerevisiae, where there is an increase in m(6)A levels during sporulation. The methyltransferase, Ime4, is responsible for this modification and has a role in the initiation of meiosis. However, neither the function, nor the extent of distribution of this nucleotide modification is established. We demonstrate that in S. cerevisiae, substantial levels of internal adenosine methylation are present in the GpA context in mRNA from sporulating cells, which is consistent with the preferred methylation consensus of higher eukaryotes. Based upon our quantification data, every second transcript could contain one m(6)A during meiosis. As methylation is distributed across all mRNA size ranges, it is likely that m(6)A is not limited to a small population of messages. We developed a new antibody based method for identifying m(6)A containing messages, and using this method the transcripts of three key, early regulators of meiosis, IME1, IME2 and IME4 itself, were identified as being methylated. The position of m(6)A in IME2 was narrowed down to a region in the 3'-end. Methylation of these and other targets suggests mechanisms by which IME4 could control developmental choices leading to meiosis.