gebhart/patrepeval huggingface dataset:
Recent progress in luminescent and colorimetric chemosensors for detection of thiols (2013)

In the past few decades, the development of optical probes for thiols has attracted great attention because of the biological importance of the thiol-containing molecules such as cysteine (Cys), homocysteine (Hcy), and glutathione (GSH). This tutorial review focuses on various thiol detection methods based on luminescent or colorimetric spectrophotometry published during the period 2010-2012. The discussion covers a diversity of sensing mechanisms such as Michael addition, cyclization with aldehydes, conjugate addition-cyclization, cleavage of sulfonamide and sulfonate esters, thiol-halogen nucleophilic substitution, disulfide exchange, native chemical ligation (NCL), metal complex-displace coordination, and nanomaterial-related and DNA-based chemosensors.
68. Studies in relation to biosynthesis. Part XV. Origin of terpenoid structures in mycelianamide and mycophenolic acid (1958)

A. J. Birch, R. J. English, R. A. Massy-Westropp and H. Smith, J. Chem. Soc., 1958, 369 DOI: 10.1039/JR9580000369
Efficient implementation of a least-squares based algorithm for noisy input-output systems (2002)

A new least-squares based method is established to perform unbiased parameter estimation of linear systems from noisy input and output measurements. The significance of the developed method lies in its improved computational efficiency since the underlying noisy system is now identified in a direct manner, with the augmented noisy system being introduced only as an auxiliary system but not being actually identified. Simulation results confirm that the presented efficient implementation scheme can retain the same estimation accuracy with reduced numerical costs.
The Economic Structure of World Tourism (2009)

The economic development of world regions has been linked increasingly to tourism development and particularly to the volume of tourist arrivals. International tourism is a form of trade that represents exports as tourist arrivals. Particular countries have been more or less successful in developing tourism exports and imports. It has been assumed sometimes that most world regional international tourism flows from the developed to the underdeveloped world and forms a process of foreign exchange income from developed to underdeveloped economies. This paper examines the question of which countries are linked economically in world tourism and, more importantly, analyses the structure of this linkage.
Creation of a Biological Pacemaker by Cell Fusion (2007)

As an alternative to electronic pacemakers, we explored the feasibility of converting ventricular myocytes into pacemakers by somatic cell fusion. The idea is to create chemically induced fusion between myocytes and syngeneic fibroblasts engineered to express HCN1 pacemaker channels (HCN1-fibroblasts). HCN1-fibroblasts were fused with freshly isolated guinea pig ventricular myocytes using polyethylene-glycol 1500. In vivo fused myocyte-HCN1-fibroblast cells exhibited spontaneously oscillating action potentials; the firing frequency increased with beta-adrenergic stimulation. The heterokaryons created ectopic ventricular pacemaker activity in vivo at the site of cell injection. Coculture of nonfused HCN1-fibroblasts and myocytes without polyethylene-glycol 1500 revealed no evidence of dye transfer, demonstrating that the I(f)-mediated pacemaker activity arises from heterokaryons rather than electrotonic coupling. This nonviral, non-stem cell approach enables autologous, adult somatic cell therapy to create biopacemakers.
태양 복사열이 콘크리트 매트기초의 내부 온도분포에 미치는 영향에 관한 해석적 연구 (2017)

태양 복사가 콘크리트 매트기초 내부 온도 분포에 미치는 영향에 대한 해석적 연구를 수행하였다. 태양복사량 산정을 위해 Zhang and Huang 모델을 사용하였다. 열전달 방정식과 Galerkin 방법을 이용하여 1차원 열전달 유한 요소 정식화를 수행하였으며, MATLAB을 사용하여 유한요소 해석코드를 작성하였다. 작성된 해석코드를 바탕으로 태양복사를 고려한 콘크리트 매트기초의 수화열 해석을 수행하였다. 해석결과, 태양복사가 매트기초 내부-표면부 최대온도차를 줄여주는 효과를 보임을 확인하였다. 또한 이러한 효과는 하절기타설시, 콘크리트 초기온도가 클수록, 그리고 매트기초의 두께가 두꺼울수록 더욱 뚜렷해짐을 확인 하였다. 본 연구는 콘크리트 매트기초의 수화열 해석시 해석결과의 과대평가를 피하기 위해서 태양 복사의 영향을 고려해야 함을 권고한다.
An overview of digital spectrometers for MR imaging (1992)

Most magnetic resonance (MR) imaging systems were originally designed with analog spectrometers, since that was the "state of the art" in the late 1970s, when they were developed. Advances in technology have allowed the design of radio-frequency electronics with a much larger percentage of digital components while the cost of such components has decreased. This has given manufacturers the incentive to develop new spectrometers that incorporate these electronics for cost reduction and potentially better performance. Upgrades and new models of MR units have become available with these so-called "digital spectrometers." Because of the interest in the new systems, the Instrumentation Subcommittee of the Basic Science Council of the Society for Magnetic Resonance Imaging has produced this report to review the basic features of analog and digital spectrometers to help the MR imaging community better understand the similarities and differences of these systems. Some details of actual commercial implementations were left out to focus on the basic features. Regardless, the authors hope they have provided a readable introduction to this important topic.
TP-CRAHN: a Transport Protocol for Cognitive Radio Ad-Hoc Networks (2009)

Existing research in transport protocols for wireless ad-hoc networks has focused on reliable end-to-end packet delivery under uncertain channel conditions, route failures due to node mobility and link congestion. In a cognitive radio (CR) environment, there are several key challenges that must be addressed apart from the above concerns. The intermittent spectrum sensing undertaken by the CR users, the activity of the licensed users of the spectrum, large-scale bandwidth variation based on spectrum availability, and the channel switching process need to be considered in the transport protocol design. In this paper, a window-based transport protocol for CR ad-hoc networks, TP-CRAHN, is proposed that distinguishes each of these events by a combination of explicit feedback from the intermediate nodes and the destination. This is achieved by adapting the classical TCP rate control algorithm running at the source to closely interact with the physical layer channel information, the link layer functions of spectrum sensing and buffer management, and a predictive mobility framework that is developed at the network layer. To the best of our knowledge, this is the first work on the transport layer to specifically address the concerns of the CR ad-hoc networks and our approach is thoroughly validated by simulation experiments.
Risk Factor Variability and Coronary Heart Disease (1990)

Present attempts to identify genes contributing to coronary heart disease (CHD) risk focus on "candidate genes". With respect to CHD this could be any gene whose protein product is directly or indirectly involved in atherogenesis, thrombogenesis or thrombolysis/fibrinolysis. Genes that exhibit associations with absolute risk factor levels may be referred to as "level genes" to distinguish them from "variability genes", which are genes involved in establishing the framework within which environmental influences may cause risk factor variation. In a series of persons recruited from the Norwegian Twin Panel, confirmatory evidence for level gene effect with respect to apolipoprotein B (apoB) concentration was found with an XbaI polymorphism in DNA at the apoB locus corresponding to residue 2,488 in the mature protein. Evidence for variability gene effect with respect to apoB as well as body mass index emerged with DNA variants in the 3' part of the apoB gene. Level gene effect with respect to apolipoprotein A-I (apoA-I) and high density lipoprotein (HDL) cholesterol as well apparent variability gene effect with respect to total and LDL cholesterol were detected with a DNA polymorphism at the cholesteryl ester transfer protein (CETP) locus. The first example of interaction between normal genes in determining risk factor level was uncovered in analysis of the apolipoprotein E (apoE) polymorphism and a restriction fragment length polymorphism (RFLP) at the low density lipoprotein receptor (LDLR) locus. An LDLR gene identified by presence of a PvuII restriction site eliminated completely the well known effect of the apoE4 allele on cholesterol level. Finally, in families where high Lp(a) lipoprotein level (a well established risk factor for CHD) segregated as a Mendelian trait, very close linkage with an RFLP at the plasminogen locus was established and DNA variation at the LPA locus reflecting varying numbers of a structure homologous to the "kringle IV" region of plasminogen was uncovered.
Inhibition of Cytochrome P450c11 by Biogenic Amines and an Aziridine Precursor, 2-(4-Acetoxyphenyl)-2-Chloro-N-Methyl-Ethylammonium Chloride (2000)

The interaction of several biogenic amines and Compound A (2-(4-acetoxyphenyl)-2-chloro- N-methyl-ethylammonium chloride), an analogue of the active substance in a HPLC fraction isolated from the shrub, Salsola tuberculatiformis Botsch., with cytochrome P450c11 was investigated. Noradrenaline, octopamine and Compound A inhibited the type I DOC induced difference spectrum of P450c11 and elicited a type II difference spectrum when added alone. The Ks-values for noradrenaline, octopamine, and Compound A were 0.8 mM, 0.16 mM and 0.36 mM, respectively. Dopamine, adrenaline and synephrine did not interact with, or inhibit, P450c11. Further investigation of Compound A indicated that it is a mixed inhibitor of sheep P450c11 with a stronger competitive (Kic = 106-110 microM) than uncompetitive (Kiu = 667-737 microM) element, and that it inhibits the conversion of deoxycorticosterone to corticosterone by human 11beta-hydroxylase and aldosterone synthase with EC50 values of 97 microM and 190 microM, respectively, in fetal calf serum.
A SOFTWARE FOR SIMULATION OF FERMENTATION PROCESSES (2010)

Fermentation is a key process stage in ethanol production and has a high incidence in the overall process efficiency in distillery. For improving this efficiency, a rigorous analysis for defining the best choice in operation variables is needed. Simulation of the process is a recognised way for doing such an analysis. In this paper, the software tool FERMENTA ® for simulation of fermentation processes is presented. This software tool allows simulation of continuous and discontinuous modes of fermentation. In the continuous mode of operation, several stages can be considered. In the batch mode, alternatives for feeding (batch, fed batch with different politics) can be analysed. The mathematical model includes non-stationary balances for biomass, substrate, ethanol, oxygen, energy. The kinetic expression can be selected by the user among more than 30 possibilities, taking or not into account inhibition factors in the process. Parameters in this equation can be estimated from experimental data. The result is a useful software tool that can be used for analysis of fermentation processes in industry and also for academic purposes. In this paper, the software is described and some case studies used for showing its possibilities.
GROWTH OF RANGE CATTLE PROTECTED FROM HORN FLIES (<i>Haematobia irritans</i>) BY EAR TAGS IMPREGNATED WITH FENVALERATE (1982)

An experiment was conducted on a ranch to evaluate the efficacy of polyvinyl ear tags impregnated with fenvalerate to control horn flies and to improve growth of steers on range. An experimental tag, weighing 10.8 g and containing 7.2% fenvalerate by weight, was attached to each ear of yearling steers when they were moved to summer range in May. The tags were evaluated in combination with zeranol implanted as a growth stimulant during a 115-day grazing period. Release of fenvalerate from the tags kept a treated group of animals completely fly-free. At the end of the experiment, liveweight gain due to slow release of fenvalerate was increased by 18.5% for implanted and 17.7% for unimplanted animals. Increases due to zeranol implants were 7.1% for animals protected and 6.3% for those unprotected from horn flies. No statistical evidence was found for interaction between responses to the impregnated ear tags and growth stimulator implants in increasing the rate of gain in weight of the steers on pasture. The results of this experiment under ranching conditions corresponded closely with basic measurements on the impact of horn flies on productivity of cattle in a model for host-parasite regulation. Key words: Cattle, flies, ear tags, Haematobia irritans, fenvalerate
Strength of clear corneal incisions in cadaver eyes (1996)

Clear corneal incisions 2.0 mm or greater in length demonstrate resistance to leakage comparable to similarly constructed scleral tunnel incisions.
Transdermal Photopolymerization of Poly (Ethylene Oxide)-Based Injectable Hydrogels for Tissue-Engineered Cartilage (1999)

Transdermal photopolymerization, a minimally invasive method for implantation, was used to subcutaneously place a mixture of polymer and isolated chondrocytes to regenerate cartilage tissue in vivo. Semi-interpenetrating networks of varying proportions of poly (ethylene oxide)dimethacrylate and poly(ethylene oxide) and primary bovine articular chondrocytes were implanted in athymic mice. Four mice (12 implants) were harvested at 2, 4, and 7 weeks. Chondrocytes survived implantation and photopolymerization and formed neocartilage containing 1.5 to 2.9% wet weight collagen and 4 to 7% glycosaminoglycan. Thirty-five percent of the total collagen was type II collagen. Histologic analysis exhibited tissue structure resembling neocartilage, and safranin O staining demonstrated glycosaminoglycan distribution throughout the hydrogels. This study demonstrates the potential use of transdermal photopolymerization for minimally invasive subcutaneous implantation of hydrogels and chondrocytes for in vivo cartilage regeneration. (Plast. Reconstr. Surg. 104: 1014, 1999.)
System for 3-D Real-Time Tracking of MRI-Compatible Devices by Image Processing (2008)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> Real-time processing of MRIs is reported as a method of 3-D tracking of mechanical devices within the field of view using passive microcoil fiducials. The specific implementation described makes use of two scan planes for full 3-D tracking of a 5-DOF manipulator arm used for prostate biopsy under image guidance. Real-time tracking was observed with a maximum update rate of 0.42 frames per second for a maximum probe velocity of 10 mm/s. The localization of fiducials had a mean error of 0.36 (<formula formulatype="inline"><tex>$\pm$</tex> </formula>0.17) mm ( <formula formulatype="inline"><tex>$p ≪ 0.02$</tex> </formula>), leading to a mean error in the needle tip position of 2.6 (<formula formulatype="inline"><tex>$\pm$</tex></formula>0.3) mm (<formula formulatype="inline"> <tex>$p ≪ 0.05$</tex></formula>). </para>
Correlation Equation for Predicting Single-Collector Efficiency in Physicochemical Filtration in Saturated Porous Media (2003)

A new equation for predicting the single-collector contact efficiency (eta0) in physicochemical particle filtration in saturated porous media is presented. The correlation equation is developed assuming that the overall single-collector efficiency can be calculated as the sum of the contributions of the individual transport mechanisms--Brownian diffusion, interception, and gravitational sedimentation. To obtain the correlation equation, the dimensionless parameters governing particle deposition are regressed against the theoretical value of the single-collector efficiency over a broad range of parameter values. Rigorous numerical solution of the convective-diffusion equation with hydrodynamic interactions and universal van der Waals attractive forces fully incorporated provided the theoretical single-collector efficiencies. The resulting equation overcomes the limitations of current approaches and shows remarkable agreement with exact theoretical predictions of the single-collector efficiency over a wide range of conditions commonly encountered in natural and engineered aquatic systems. Furthermore, experimental data are in much closer agreement with predictions based on the new correlation equation compared to other available expressions.
Space radiation equivalence for effects on transistors Final report, 15 May 1965 - 15 Nov. 1966 (1967)

Space radiation equivalences for permanent damage to silicon transistors by measuring changes in transistor parameters after exposure to proton, electron, and gamma ray irradiation
Enalapril and Losartan Reduce Sympathetic Hyperactivity in Patients with Chronic Renal Failure (2003)

The aim of this study was to compare the effects on BP and sympathetic activity of chronic treatment with an angiotensin (Ang)-converting enzyme (ACE) inhibitor and an AngII receptor blocker in hypertensive patients with chronic renal failure (CRF). In ten stable hypertensive CRF patients (creatinine clearance, 46 +/- 17 ml/min per 1.73 m(2)), muscle sympathetic nerve activity (MSNA), plasma renin activity (PRA), baroreceptor sensitivity, and 24-h ambulatory BP were measured in the absence of antihypertensive drugs (except diuretics) after 6 wk of enalapril (10 mg orally) and after 6 wk of losartan (100 mg orally). The order of the three phases was randomized. Normovolemia was controlled with diuretics and confirmed with extracellular fluid volume measurements throughout the study. Both enalapril and losartan reduced MSNA (from 33 +/- 10 to 27 +/- 13 and 27 +/- 13 bursts/min, respectively; P < 0.05) and average 24-h BP (from 141 +/- 8/93 +/- 8 to 124 +/- 9/79 +/- 8 and 127 +/- 8/81 +/- 9 mmHg; P < 0.01). PRA was not different during the treatments. The change in BP and the change in MSNA during the treatments were correlated (r = 0.70 and r = 0.63, respectively; both P < 0.05). Baroreceptor sensitivity was not affected by the treatments. This is the first study to compare the effects of ACE inhibition and AngII blockade on MSNA. In hypertensive CRF patients, enalapril and losartan equally reduced BP and MSNA. Differences in modes of action of the two drugs did not result in differences in effects on MSNA, supporting the view that AngII-mediated mechanisms contribute importantly in the pathogenesis of sympathetic hyperactivity in these patients.
Activation of Rho GTPases Triggers Structural Remodeling and Functional Plasticity in the Adult Rat Visual Cortex (2011)

A classical example of age-dependent plasticity is ocular dominance (OD) plasticity, triggered by monocular deprivation (MD). Sensitivity of cortical circuits to a brief period of MD is maximal in juvenile animals and downregulated in adult age. It remains unclear whether a reduced potential for morphological remodeling underlies this downregulation of physiological plasticity in adulthood. Here we have tested whether stimulation of structural rearrangements is effective in promoting experience-dependent plasticity in adult age. We have exploited a bacterial protein toxin, cytotoxic necrotizing factor 1 (CNF1), that regulates actin dynamics and structure of neuronal processes via a persistent activation of Rho GTPases. Injection of CNF1 into the adult rat visual cortex triggered a long-lasting activation of the Rho GTPase Rac1, with a consequent increase in spine density and length in pyramidal neurons. Adult rats treated with CNF1, but not controls, showed an OD shift toward the open eye after MD. CNF1-mediated OD plasticity was selectively attributable to the enhancement of open-eye responses, whereas closed-eye inputs were unaffected. This effect correlated with an increased density of geniculocortical terminals in layer IV of monocularly deprived, CNF1-treated rats. Thus, Rho GTPase activation reinstates OD plasticity in the adult cortex via the potentiation of more active inputs from the open eye. These data establish a direct link between structural remodeling and functional plasticity and demonstrate a role for Rho GTPases in brain plasticity in vivo. The plasticizing effects of Rho GTPase activation may be exploited to promote brain repair.
Automated processing pipeline for neonatal diffusion MRI in the developing Human Connectome Project (2018)

The developing Human Connectome Project is set to create and make available to the scientific community a 4-dimensional map of functional and structural cerebral connectivity from 20 to 44 weeks post-menstrual age, to allow exploration of the genetic and environmental influences on brain development, and the relation between connectivity and neurocognitive function. A large set of multi-modal MRI data from fetuses and newborn infants is currently being acquired, along with genetic, clinical and developmental information. In this overview, we describe the neonatal diffusion MRI (dMRI) image processing pipeline and the structural connectivity aspect of the project. Neonatal dMRI data poses specific challenges, and standard analysis techniques used for adult data are not directly applicable. We have developed a processing pipeline that deals directly with neonatal-specific issues, such as severe motion and motion-related artefacts, small brain sizes, high brain water content and reduced anisotropy. This pipeline allows automated analysis of in-vivo dMRI data, probes tissue microstructure, reconstructs a number of major white matter tracts, and includes an automated quality control framework that identifies processing issues or inconsistencies. We here describe the pipeline and present an exemplar analysis of data from 140 infants imaged at 38-44 weeks post-menstrual age.
Immunomodulatory activity of boswellic acids of Boswellia serrata Roxb. (2003)

Extract of gum resin of B. serrata containing 60% acetyl 11-keto beta boswellic acid (AKBA) along with other constituents such as 11-keto beta-boswellic acid (KBA), acetyl beta-boswellic acid and beta-boswellic acid has been evaluated for antianaphylactic and mast cell stabilizing activity using passive paw anaphylaxis and compound 48/80 induced degranulation of mast cell methods. The extract inhibited the passive paw anaphylaxis reaction in rats in dose-dependant manner (20, 40 and 80 mg/kg, po). However, the standard dexamethasone (0.27 mg/kg, po) revealed maximum inhibition of edema as compared to the extract. A significant inhibition in the compound 48/80 induced degranulation of mast cells in dose-dependant manner (20, 40 and 80 mg/kg, po) was observed thus showing mast cell stabilizing activity. The standard disodium cromoglycate (50 mg/kg, ip) was found to demonstrate maximum per cent protection against degranulation as compared to the extract containing 60% AKBA. The results suggest promising antianaphylactic and mast cell stabilizing activity of the extract.
Recombinant histamine-releasing factor enhances IgE-dependent IL-4 and IL-13 secretion by human basophils (1997)

Human recombinant histamine-releasing factor (HrHRF) is known to directly stimulate histamine release and IL-4 secretion from basophils of selected atopic donors in a reaction requiring the expression of a particular type of IgE, referred to as IgE+. In this study, HrHRF is shown to affect the IgE-mediated release of IL-4, IL-13, and histamine from basophils not normally releasing to this protein (i.e, those expressing IgE-). Priming with several different concentrations of HrHRF for 15 min enhanced basophil secretion of IL-4 and histamine after 4 h in a dose-dependent fashion following activation with anti-IgE Ab (10 ng/ml). This effect of HrHRF priming also occurred in cultures activated with 1 or 100 ng/ml of anti-IgE Ab. The secretion of IL-13 protein was enhanced similarly by HrHRF priming in cultures stimulated for 16 to 20 h with anti-IgE Ab. There were, however, no apparent changes in the secretion of histamine or cytokine by basophils primed with HrHRF and activated with the IgE-independent secretogogue, FMLP. These findings suggest that HrHRF modifies the response of basophils for IgE-dependent secretion by binding to a specific receptor, broadening the possible role of this protein in chronic allergic inflammation.