gebhart/patrepeval huggingface dataset:
Accurate Real-time Map Matching for Challenging Environments (2016)

We present the SnapNet system, which provides accurate real-time map matching for cellular-based trajectory traces. Such traces are characterized by input locations that are far from the actual road segment, errors on the order of kilometers, back-and-forth transitions, and highly sparse input data. SnapNet applies a series of filters to handle the noisy locations and an interpolation stage to address the data sparseness. At the core of SnapNet is a novel incremental HMM algorithm that combines digital map hints in the estimation process and a number of heuristics to reduce the noise and provide real-time estimations. Evaluation of SnapNet using actual traces from different cities covering more than 400 km shows that it can achieve a precision and recall of more than 90% under noisy coarse-grained input location estimates. This maps to over 97% and 34% enhancement in precision and recall, respectively, when compared to the traditional HMM map-matching algorithms. Moreover, SnapNet has a latency of 0.58 ms per location estimate.
Helix-Rod Host-Guest Complexes with Shuttling Rates Much Faster than Disassembly (2011)

Dynamic assembly is a powerful fabrication method of complex, functionally diverse molecular architectures, but its use in synthetic nanomachines has been hampered by the difficulty of avoiding reversible attachments that result in the premature breaking apart of loosely held moving parts. We show that molecular motion can be controlled in dynamically assembled systems through segregation of the disassembly process and internal translation to time scales that differ by four orders of magnitude. Helical molecular tapes were designed to slowly wind around rod-like guests and then to rapidly slide along them. The winding process requires helix unfolding and refolding, as well as a strict match between helix length and anchor points on the rods. This modular design and dynamic assembly open up promising capabilities in molecular machinery.
Regulatory Mechanisms Underlying the Expression of Prolactin Receptor in Chicken Granulosa Cells (2017)

Prolactin (PRL) has both pro- and anti-gonadal roles in the regulation of avian ovarian functions through its interaction with the receptor (PRLR). However, neither the pattern of expression of PRLR nor its regulatory mechanisms during follicle development have been clearly defined. The objective of the present study was to investigate mechanisms of PRLR expression in chicken granulosa cells. Levels of PRLR transcript were highest in the stroma and walls of follicles < 2 mm in diameter and progressively declined with the maturation of follicles. In preovulatory follicles, PRLR was expressed at higher levels in granulosa than theca layers. FSH exerted the greatest stimulatory effect on PRLR and StAR expression in cultured granulosa cells of the 6-8 mm follicles but this effect declined as follicles matured to F1. In contrast, LH did not alter the expression of PRLR in granulosa cells of all follicular classes but increased levels of StAR in F2 and F1 granulosa cells. Both non-glycosylated- (NG-) and glycosylated- (G-) PRL upregulated basal PRLR expression in granulosa cells of the 6-8 mm, F3 or F1 follicles but had little effect in F2 follicles. Furthermore, FSH-stimulated PRLR expression was reduced by the addition of either isoform of PRL especially in F2 granulosa cells. These results indicate that PRLR is differentially distributed and regulated by FSH or PRL variants independently or in combination in the follicular hierarchy. By using activators and inhibitors, we further demonstrated that multiple signaling pathways, including PKA, PKC, PI3K, mTOR and AMPK, are not only directly involved in, but they can also converge to modulate ERK2 activity to regulate FSH-mediated PRLR and StAR expression in undifferentiated granulosa cells. These data provide new insights into the regulatory mechanisms controlling the expression of PRLR in granulosa cells.
Toll-Like Receptor 7 Agonist GS-9620 Induces HIV Expression and HIV-Specific Immunity in Cells from HIV-Infected Individuals on Suppressive Antiretroviral Therapy (2017)

Antiretroviral therapy can suppress HIV replication to undetectable levels but does not eliminate latent HIV, thus necessitating lifelong therapy. Recent efforts to target this persistent reservoir have focused on inducing the expression of latent HIV so that infected cells may be recognized and eliminated by the immune system. Toll-like receptor (TLR) activation stimulates antiviral immunity and has been shown to induce HIV from latently infected cells. Activation of TLR7 leads to the production of several stimulatory cytokines, including type I interferons (IFNs). In this study, we show that the selective TLR7 agonist GS-9620 induced HIV in peripheral blood mononuclear cells (PBMCs) from HIV-infected individuals on suppressive antiretroviral therapy. GS-9620 increased extracellular HIV RNA 1.5- to 2-fold through a mechanism that required type I IFN signaling. GS-9620 also activated HIV-specific T cells and enhanced antibody-mediated clearance of HIV-infected cells. Activation by GS-9620 in combination with HIV peptide stimulation increased CD8 T cell degranulation, production of intracellular cytokines, and cytolytic activity. T cell activation was again dependent on type I IFNs produced by plasmacytoid dendritic cells. GS-9620 induced phagocytic cell maturation and improved effector-mediated killing of HIV-infected CD4 T cells by the HIV envelope-specific broadly neutralizing antibody PGT121. Collectively, these data show that GS-9620 can activate HIV production and improve the effector functions that target latently infected cells. GS-9620 may effectively complement orthogonal therapies designed to stimulate antiviral immunity, such as therapeutic vaccines or broadly neutralizing antibodies. Clinical studies are under way to determine if GS-9620 can target HIV reservoirs.<b>IMPORTANCE</b> Though antiretroviral therapies effectively suppress viral replication, they do not eliminate integrated proviral DNA. This stable intermediate of viral infection is persistently maintained in reservoirs of latently infected cells. Consequently, lifelong therapy is required to maintain viral suppression. Ultimately, new therapies that specifically target and eliminate the latent HIV reservoir are needed. Toll-like receptor agonists are potent enhancers of innate antiviral immunity that can also improve the adaptive immune response. Here, we show that a highly selective TLR7 agonist, GS-9620, activated HIV from peripheral blood mononuclear cells isolated from HIV-infected individuals with suppressed infection. GS-9620 also improved immune effector functions that specifically targeted HIV-infected cells. Previously published studies on the compound in other chronic viral infections show that it can effectively induce immune activation at safe and tolerable clinical doses. Together, the results of these studies suggest that GS-9620 may be useful for treating HIV-infected individuals on suppressive antiretroviral therapy.
www.australianprescriber.com (1998)

By the year 2020, paper biomedical journals will be extinct. This was a view expressed at an international meeting of...
Recurrent Convolutional Neural Networks for Scene Parsing (2013)

Scene parsing is a technique that consist on giving a label to all pixels in an image according to the class they belong to. To ensure a good visual coherence and a high class accuracy, it is essential for a scene parser to capture image long range dependencies. In a feed-forward architecture, this can be simply achieved by considering a sufficiently large input context patch, around each pixel to be labeled. We propose an approach consisting of a recurrent convolutional neural network which allows us to consider a large input context, while limiting the capacity of the model. Contrary to most standard approaches, our method does not rely on any segmentation methods, nor any task-specific features. The system is trained in an end-to-end manner over raw pixels, and models complex spatial dependencies with low inference cost. As the context size increases with the built-in recurrence, the system identifies and corrects its own errors. Our approach yields state-of-the-art performance on both the Stanford Background Dataset and the SIFT Flow Dataset, while remaining very fast at test time.
Effects at Two Years of a Low-Fat, High-Carbohydrate Diet on Radiologic Features of the Breast: Results From a Randomized Trial (1997)

These results show that after 2 years, a low-fat, high-carbohydrate diet reduced the area of mammographic density, a radiographic feature of the breast that is a risk factor for breast cancer. Longer observation of a larger number of subjects will be required to determine whether these effects are associated with changes in risk of breast cancer.
Triple Role of Platelet-Activating Factor in Eosinophil Migration Across Monolayers of Lung Epithelial Cells: Eosinophil Chemoattractant and Priming Agent and Epithelial Cell Activator (1998)

Infiltration of eosinophils into the lung lumen is a hallmark of allergic asthmatic inflammation. To reach the lung lumen, eosinophils must migrate across the vascular endothelium, through the interstitial matrix, and across the lung epithelium. The regulation of this process is obscure. In this study, we investigated the migration of human eosinophils across confluent monolayers of either human lung H292 epithelial cells or primary human bronchial epithelial cells. Established eosinophil chemoattractants (IL-8, RANTES, platelet-activating factor (PAF), leukotriene B4, and complement fragment 5a (C5a)) or activation of the epithelial cells with IL-1beta induced little eosinophil transmigration (<7% in 2 h). In contrast, addition of PAF in combination with C5a induced extensive (>20%) transepithelial migration of unprimed and IL-5-primed eosinophils. Eosinophil migration assessed in a Boyden chamber assay, i.e., without an epithelial monolayer, was only slightly increased upon addition of PAF and C5a. Preincubation of eosinophils with the PAF receptor antagonist WEB 2086 only inhibited migration of unprimed eosinophils toward PAF and C5a, whereas preincubation of epithelial cells with WEB 2086 abolished migration of both IL-5-primed and unprimed eosinophils. This latter result indicated the presence of PAF receptors on epithelial cells. Indeed, addition of PAF to epithelial cells induced an increase in cytosolic free Ca2+, which was blocked by the PAF receptor antagonists WEB 2086 and TCV-309. Our results show that PAF induces permissive changes in epithelial cells, and that PAF acts as a chemoattractant and priming agent for the eosinophils.
A physically insightful approach to the design and accuracy assessment of flux observers for field oriented induction machine drives (1994)

Rotor flux observers can provide an attractive means for achieving direct field oriented control of induction machines. This paper presents a physics-based design methodology and uses it to evaluate open-loop observers and to develop a new closed-loop flux observer. It is shown that the new flux observer is a straightforward structure with properties that combine the best features of known methods. A distinction is made between observers, which use only integration and feedback summation operations, and those estimation methods requiring approximate differentiation which are, in essence, "cancellation" methods. Furthermore, a clear distinction is made between accuracy and dynamic robustness of the observer. This distinction is important because the accuracy of flux observers for induction machines is inherently parameter sensitive, whereas robustness of observers, in a controls sense, is not parameter sensitive. Moreover, it is shown how flux observers can provide robust field oriented control because the flux angle is substantially more correct than the flux magnitude. A distinctive form of frequency response function (FRF) analysis similar to that used in classical control engineering is demonstrated to be a useful and insightful tool even though flux observers are multiple-input, multiple-output systems. Finally, the limits of such flux observers are experimentally evaluated.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Dexamethasone Inhibits Collagen Degradation Induced by the Combination of Interleukin-1 and Plasminogen in Cartilage Explant Culture. (1999)

Glucocorticoids ameliorate erosion in animal osteoarthritis (OA) models and suppress synthesis of matrix metalloproteinases (MMP). However, in in vitro studies, their inhibitory effects on matrix degradation of cartilage have not been well documented by monitoring aggrecan. Collagen was monitored in this study to examine the effects of dexamethasone in cartilage explant culture. Dexamethasone clearly blocked collagen degradation induced by the combination of interleukin-1 (IL-1) and plasminogen at the concentration of 10(-9) M, which is much lower than the concentrations reportedly required to inhibit matrix synthesis. In addition, MMP-1 and MMP-3 were suppressed by dexamethasone treatment in a similar range of concentrations. The conversion of plasminogen to plasmin, however, was not blocked by treatment with dexamethasone. These results suggest that the inhibitory effect of dexamethasone on collagen degradation may be due to suppression of MMP production rather than suppression of fibrinolytic cascade. Thus, the ability of glucocorticoids to inhibit matrix degradation in vitro, which could be clearly shown by monitoring collagen degradation, may endorse their efficacy in animal OA models and suggest potential therapeutic effectiveness.
Transformation to zero offset for mode-converted waves (1992)

Abstract The transformation to zero offset (TZO) of prestack seismic data for a constant-velocity medium is well understood and is readily implemented when dealing with either P-waves or S-waves. TZO is achieved by inserting a dip moveout (DMO) process to correct data for the influence of dip, either before or after normal moveout (NMO) correction (Hale, 1984; Forel and Gardner, 1988). The TZO process transforms prestack seismic data in such a way that common-midpoint (CMP) gathers are closer to being common reflection point gathers after the transformation.
Modified forms for Glan-Thompson and Rochon prisms. (1968)

Glan-Thompson and Rochon prisms modified by replacing one of two calcite halves of cemented oriented birefringent crystals with glass
Inductive power transfer system for driving multiple OLED lighting panels (2014)

This paper will present an inductive power transfer system for driving multiple organic light-emitting diode (OLED) lighting panels. Each panel is driven by an output of a daisy-chained transformer (DCT) structure through a detachable transformer, where the DCT structure is driven by a switching network. Apart from easy and safe operation, the system offers users with a modular, scalable, low-maintenance, and hot-swappable platform for large-area illumination. Design, modeling, and analysis of the system under normal and faulty operating conditions and misalignment of the detachable transformer will be discussed. Experimental results of a prototype having four OLED lighting panels will be studied and compared with theoretical predictions.
A general model of web graphs (2003)

Abstract We describe a very general model of a random graph process whose proportional degree sequence obeys a power law. Such laws have recently been observed in graphs associated with the world wide web. © 2003 Wiley Periodicals, Inc. Random Struct. Alg., 2003
Two Receptor Interaction Domains in the Corepressor, N-CoR/RIP13, Are Required for an Efficient Interaction with Rev-erbA  and RVR: Physical Association is Dependent on the E Region of the Orphan Receptors (1996)

Rev-erbA alpha and RVR/Rev-erb beta/BD73 are orphan steroid receptors that have no known ligands in the 'classical sense'. These 'orphans' do not activate transcription, but function as dominant transcriptional silencers. The thyroid hormone receptor (TR) and the retinoic acid receptor (RAR) act as transcriptional silencers by binding corepressors (e.g. N-CoR/RIP13 and SMRT/TRAC-2) in the absence of ligands. The molecular basis of repression by orphan receptors, however, remains obscure, and it is unclear whether these corepressors mediate transcriptional silencing by Rev-erbA alpha and RVR. Recently, two new variants of N-CoR have been described, RIP13a and RIP13delta1. The characterisation of these splice variants has identified a second receptor interaction domain (ID-II), in addition to the previously characterised interaction domain (ID-I). This investigation utilised the mammalian two hybrid system and transfection analysis to demonstrate that Rev-erbA alpha and RVR will not efficiently interact with either ID-I or ID-II separately from RIP13a or RIP13delta1. However, they interact efficiently with a domain composed of ID-I and ID-II from RIP13a. Interestingly, the interaction of Rev-erbA alpha and RVR is strongest with ID-I and ID-II from RIP13delta1. Detailed deletion analysis of the orphan receptor interaction with RIP13/N-CoR rigorously demonstrated that the physical association was critically dependent on an intact E region of Rev-erbA alpha and RVR. Over-expression of the corepressor interaction domains (i.e. dominant negative forms of N-CoR/RIP13) could alleviate orphan receptor-mediated repression of transactivation by GALVP16. This demonstrated that these regions could function as anti-repressors. In conclusion, these data from two independent approaches demonstrate that repression by Rev-erbA alpha and RVR is mediated by an interaction of ID-I and ID-II of N-CoR, RIP13a and delta1 with the putative ligand binding domain of the orphan receptors.
Theoretical aspects and practical potentials of rapid gas analysis in capillary gas chromatography (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTheoretical aspects and practical potentials of rapid gas analysis in capillary gas chromatographyRobert. Tijssen, Nico. Van den Hoed, and M. Emile. Van KreveldCite this: Anal. Chem. 1987, 59, 7, 1007–1015Publication Date (Print):April 1, 1987Publication History Published online1 May 2002Published inissue 1 April 1987https://doi.org/10.1021/ac00134a018RIGHTS & PERMISSIONSArticle Views99Altmetric-Citations53LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (4 MB) Get e-Alerts Get e-Alerts
Robust Subspace Tracking Based Blind Channel Identification In Impulsive Noise Environment (2002)

Publication in the conference proceedings of EUSIPCO, Toulouse, France, 2002
Characterizing the Smell of Marijuana by Odor Impact of Volatile Compounds: An Application of Simultaneous Chemical and Sensory Analysis (2015)

Recent US legislation permitting recreational use of marijuana in certain states brings the use of marijuana odor as probable cause for search and seizure to the forefront of forensic science, once again. This study showed the use of solid-phase microextraction with multidimensional gas chromatography-mass spectrometry and simultaneous human olfaction to characterize the total aroma of marijuana. The application of odor activity analysis offers an explanation as to why high volatile chemical concentration does not equate to most potent odor impact of a certain compound. This suggests that more attention should be focused on highly odorous compounds typically present in low concentrations, such as nonanal, decanol, o-cymene, benzaldehyde, which have more potent odor impact than previously reported marijuana headspace volatiles.
Differential Damage to Auditory Neurons and Hair Cells by Ototoxins and Neuroprotection by Specific Neurotrophins in Rat Cochlear Organotypic Cultures (1996)

Therapeutic ototoxic drugs are one of the major causes of damage in the peripheral auditory system, leading to hearing loss. In this study, we have examined the toxic actions of three classes of ototoxins (sodium salicylate, gentamicin and cisplatin) in organotypic cultures of postnatal cochlear explants. In these cultures, afferent innervation of hair cells by primary auditory neurons remained intact. Double labelling with a monoclonal antibody against neurofilament protein and a phalloidin-fluorescein isothiocyanate conjugate revealed that the three types of drugs induced differential damage to auditory neurons and hair cells in the cochlea. While gentamicin preferentially caused hair cell death, sodium salicylate specifically induced degeneration of auditory neurons. In contrast, cisplatin resulted in destruction of both auditory neurons and hair cells. Neuronal degeneration was largely prevented by the addition of neurotrophin-4/5, brain-derived neurotrophic factor and neurotrophin-3 to the culture media together with the ototoxins, while nerve growth factor and other growth factors had no effect. In contrast, the hair cell loss caused by cisplatin or gentamicin was not attenuated by the presence of neurotrophins. These results suggest that ototoxic mechanisms of salicylates, aminoglycosides and chemotherapeutic agents are different. Auditory neuronal loss induced by ototoxins may be prevented by specific neurotrophins.