gebhart/patrepeval huggingface dataset:
Two-dimensional hierarchical porous silica film and its tunable superhydrophobicity (2005)

Based on a monolayer polystyrene (PS) colloidal crystal, large-scale two-dimensional (2D) hierarchical porous silica (orderly arranged macropores and disordered mesopores in its skeleton) with a high specific surface area was fabricated by the sol–gel technique. Such material has demonstrated superhydrophilicity with a water contact angle (CA) of 5° and superhydrophobicity with a water CA of 154° after surface modification with fluoroalkylsilane. More interestingly, the water CA can be increased to 165° using a heat-deformed PS template, which suggests that the superhydrophobicity can be controlled by the template with different heat-deformed extents. Such silica films have applications in fields of adsorbent, catalytic, chromatographic support, microseparator and microfluid devices.
Personalized Ranking in eCommerce Search (2020)

We address the problem of personalization in the context of eCommerce search. Specifically, we develop personalization ranking features that use in-session context to augment a generic ranker optimized for conversion and relevance. We use a combination of latent features learned from item co-clicks in historic sessions and content based features that use item title and price. Personalization in search has been discussed extensively in the existing literature. The novelty of our work is combining and comparing content based and content agnostic features and showing that they complement each other to result in a significant improvement of the ranker. We experimentally show that our technique significantly outperforms a generic ranker in terms of Mean Reciprocal Rank (MRR). We also provide anecdotal evidence for the semantic similarity captured by the item embeddings on the eBay search engine.
Effect of Pravastatin on Coronary Disease Events in Subgroups Defined by Coronary Risk Factors (2000)

Pravastatin treatment is effective in reducing coronary heart disease events in patients with high or low risk factor status and across a wide range of pretreatment lipid concentrations.
SPECTRUM OF EPSTEIN-BARR VIRUS–ASSOCIATED DISEASES (2006)

The association between Epstein-Barr virus (EBV) and a large number of benign and malignant diseases is unique among DNA viruses. Within infected tissues, proteins that are expressed during the normal lytic and latent viral life cycle lead to cellular alterations that contribute to these EBV-associated diseases. Although the early events of EBV infection are poorly understood, increasing knowledge of the viral processes that govern viral latency has shed light upon the potential mechanisms by which EBV infection can lead to cellular transformation. Our current understanding of the role of EBV in the development of Burkitt lymphoma, Hodgkin lymphoma, nasopharyngeal carcinoma, and other EBV-associated diseases is discussed.
Intelligent output interface for intelligent medical search engine (2008)

To facilitate ordinary people to search medical information, we have built an intelligent medical Web search engine called iMed. iMed uses medical knowledge and an interactive questionnaire to find multiple diseases serving as queries. The search results of these queries are combined together and returned to the searcher in a traditional sequential order. Nevertheless, searchers still frequently miss desired information, because the traditional search result output interface cannot capture the internal structures of medical search results. This paper presents a new, intelligent search result output interface devoted to intelligent medical search. The new output interface automatically offers searchers what they want instead of waiting until they ask explicitly. It structures all the search results into a multi-level hierarchy with explicitly marked medical meanings. In this way, searchers can efficiently navigate among all the search results and quickly obtain desired information. We demonstrate the effectiveness of our techniques through an evaluation using USMLE medical exam cases.
Newcastle Disease Virus Hemagglutinin Neuraminidase as a Potential Cancer Targeting Agent (2016)

The hemagglutinin-neuraminidase (HN) protein of Newcastle disease virus (NDV) with its immunotherapeutic activities and sialic acid binding abilities is a promising cancer adjuvant. The HN was surfaced displayed on Lactococcus lactis and its cancer targeting ability was investigated via attachment to the MDA-MB231 breast cancers. To surface display the HN protein on the bacterial cell wall, HN was fused to N-acetylmuraminidase (AcmA) anchoring motif of L. lactis and expressed in Chinese hamster ovary cells. The expressed recombinant fusion proteins were purified and mixed with a culture of L. lactis and Lactobacillus plantarum. Immunofluorescence assay showed the binding of the recombinant HN-AcmA protein on the surface of the bacterial cells. The bacterial cells carrying the HN-AcmA protein interacted with the MDA-MB231 breast cancer cells. Direct and fluorescent microscopy confirmed that L. lactis and Lb. plantarum surface displaying the recombinant HN were attached to the breast cancer MDA-MB231 cells, providing evidence for the potential ability of HN in targeting to cancer cells.
Characterizing nonlinearity in Ventricular Fibrillation (1999)

The authors apply techniques from nonlinear dynamical systems theory to determine whether Ventricular Fibrillation (VF) comes from a stochastic, or a more complex nonlinear process. Using electrocardiographic (ECG) data from seven pigs during ventricular fibrillation the authors apply various surrogate data techniques to test the observed data against a series of hypotheses. Standard linear surrogate techniques demonstrate that VF is inconsistent with data generated by a monotonic nonlinear transformation of a linearly filtered noise source. Nonlinear modeling methods show that VF is consistent with the output of a system exhibiting a stable periodic orbit and small scale high dimensional structure (either noise or chaos).
SEMO: A Framework for Customer Social Networks Analysis Based on Semantics (2010)

The increasing importance of the Internet in most domains has brought about a paradigm change in consumer relations. The influence of Social Networks has entered the Customer Relationship Management domain under the coined term CRM 2.0. In this context, the need to understand and classify the interactions of customers by means of new platforms has emerged as a challenge for both researchers and professionals worldwide. This is the perfect scenario for the use of SEMO, a platform for Customer Social Networks Analysis based on Semantics and emotion mining. The platform benefits from both semantic annotation and classification and text analysis, relying on techniques from the Natural Language Processing domain. The results of the evaluation of the experimental implementation of SEMO reveal a promising and viable platform from a technical perspective.
Gastrointestinal Behçet's disease: A review (2015)

Behçet's disease (BD) is an idiopathic, chronic, relapsing, multi-systemic vasculitis characterized by recurrent oral and genital aphthous ulcers, ocular disease and skin lesions. Prevalence of BD is highest in countries along the ancient silk road from the Mediterranean basin to East Asia. By comparison, the prevalence in North American and Northern European countries is low. Gastrointestinal manifestations of Behçet's disease are of particular importance as they are associated with significant morbidity and mortality. Although ileocecal involvement is most commonly described, BD may involve any segment of the intestinal tract as well as the various organs within the gastrointestinal system. Diagnosis is based on clinical criteria - there are no pathognomonic laboratory tests. Methods for monitoring disease activity on therapy are available but imperfect. Evidence-based treatment strategies are lacking. Different classes of medications have been successfully used for the treatment of intestinal BD which include 5-aminosalicylic acid, corticosteroids, immunomodulators, and anti-tumor necrosis factor alpha monoclonal antibody therapy. Like inflammatory bowel disease, surgery is reserved for those who are resistant to medical therapy. A subset of patients have a poor disease course. Accurate methods to detect these patients and the optimal strategy for their treatment are not known at this time.
Trading The Oceans: The Brave "New" World Of Seafood Futures Contracts (2013)

“Financial markets are like the mirror of mankind. It is not the fault of the mirror if it reflects our blemishes as clearly as our beauty.” With the United States still attempting to recover from a financial crisis brought on, in part, by financial ingenuity and the relatively unforeseen risks emanating from “new” financial products, developing the idea of seafood futures contracts into another product that theoretically could cause market turmoil, may be met with a less than enthusiastic embrace. Although bowing to the urge to disregard the potential benefits for fear of the potential side effects might at first seem the prudent reaction, there are some considerable benefits to creating seafood futures contracts. Such contracts have the potential to influence an increase in seafood consumption and fishermen profitability, while enhancing market efficiency, decreasing waste, and limiting volatile price swings. With so much potential the question must be raised: “Why don’t seafood futures contracts already exist?” The answer is that they do exist, did exist, and, if the economic incentives are realized, could again exist in the United States in the near future. Part II of this Comment reviews forward and futures contracts in the United States and focuses on the creation and use of plywood, shrimp, and salmon futures contracts. Part III of this Comment examines futures contracts under U.S. law. Part IV of this Comment analyzes the potential benefits and drawbacks of seafood futures contracts. Finally, Part V focuses on how seafood futures contracts could be created and implemented.
MP19-06 MESENCHYMAL STEM-CELL THERAPY ALLEVIATES INTERSTITIAL CYSTITIS BY ACTIVATING WNT SIGNALING PATHWAY (2015)

You have accessJournal of UrologyStem Cell Research1 Apr 2015MP19-06 MESENCHYMAL STEM-CELL THERAPY ALLEVIATES INTERSTITIAL CYSTITIS BY ACTIVATING WNT SIGNALING PATHWAY Miho Song, Junsoo Park, and Myung-Soo Choo Miho SongMiho Song , Junsoo ParkJunsoo Park , and Myung-Soo ChooMyung-Soo Choo View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.998AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Interstitial cystitis (IC) is a devastating disease with no reliable treatment, but the appropriate applications of stem cell therapy remain unproven. This study evaluated the therapeutic potency of using human umbilical cord-blood derived mesenchymal stem cells (UCB-MSC) to treat IC in a rat model and investigate its responsible molecular mechanism. METHODS IC was induced in 10-weeks-old female Sprague-Dawley rats via the instillation of 0.1 M HCl or PBS (sham). After 1 week, human UCB-MSC (IC+MSC) or PBS (IC) was directly injected into the submucosal layer of the bladder. Cystometric parameters, histological examination, immunostaining, and gene expression were measured at 1 week after intervention. Statistical analysis were performed by one-way ANOVA with the Bonferroni post hoc testing. RESULTS A single injection of human UCB-MSCs significantly attenuated the irregular and decreased voiding interval in the IC group. Accordingly, denudation of the epithelium and increased inflammatory responses, mast cell infiltration, neurofilament production, and angiogenesis were observed in the IC group. These actions were prevented in the IC+MSC group. The injected UCB-MSCs successfully engrafted to the stromal and epithelial tissues and activated the Wnt signaling cascade. Interference with Wnt and epidermal growth factor receptor (EGFR) activity by small molecules abrogated the benefits of MSC therapy. CONCLUSIONS This is the first report that provides an experimental evidence of the therapeutic effects and molecular mechanisms of MSC therapy to IC using an orthodox rat animal model. Our findings not only provide the basis for clinical trials, but also advance our understanding of IC pathophysiology. © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e217 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Miho Song More articles by this author Junsoo Park More articles by this author Myung-Soo Choo More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...
Transformation of Streptococcus mutans with chromosomal and shuttle plasmid (pYA629) DNAs (1986)

Transformation (i.e., DNase-sensitive genetic transfer) of strains of Streptococcus mutans representing serotypes c and e was accomplished by using chromosomal DNA from a Rifr Strr Spcr isolate of strain GS5 (UAB525) and a chimeric plasmid, pYA629. Shuttle plasmid pYA629 comprises the S. mutans plasmid pVA318, an inducible erythromycin resistance determinant originally isolated from a group A streptococcal strain, the tetracycline resistance gene and replication region of the Escherichia coli plasmid pBR322, and the promoter region of the S. mutans gene for aspartate beta-semialdehyde dehydrogenase. The strains examined for recipient ability included those known to lack a cryptic plasmid (GS5, UA130, UA159, and MT8148) and those known to contain a widely disseminated 5.8-kilobase cryptic plasmid (LM7, V318, UA101, UA174, and 3098791). The transformation frequencies in GS5 for GS5 chromosomal antibiotic resistance markers were comparable to those reported by others, but UA101, UA130, UA159 and UA174 were transformed with both chromosomal and plasmid markers at much higher efficiencies. In a larger strain survey, strains containing the 5.8-kilobase cryptic plasmid were more frequently transformable with both chromosomal and pYA629 DNAs than were strains lacking this cryptic plasmid. All plasmid-containing strains except LM7 lost their resident cryptic plasmids when transformed with pYA629. LM7 transformed with pYA629 retained pLM7. There are therefore at least two incompatibility groups among S. mutans cryptic plasmids. yPA629 DNA isolated from either E. coli or S. mutans transformed S. mutans with equal efficiency. pYA629 DNA isolated from S. mutans transformed both restriction-deficient and restriction-proficient E. coli recipients. Therefore, the strains of S. mutans used lack a restriction-modification system for pYA629 DNA sequences. S. mutans strains that are readily transformable, display maximal cariogenicity in gnotobiotic rats, and give high scores for in vitro measures of important virulence attributes have been identified to facilitate studies on the genetic basis and control of virulence.
KOMPETENTNOST ODGAJATELJA I PREVENCIJA RIZIČNIH PONAŠANJA DJECE U PREDŠKOLSKIM USTANOVAMA (2008)

The aim of this paper was to show the results of the research of competence and attitudes of pre-school teachers in institutions in the Istria region. These results are the part of bigger research which was conducted within the scientific-action project Communities that care as a model of prevention of behavioral disorder of children and youth. Sample was constituted from 212 pre-school participants. Survey of self-appraisal of their competencies (22 variables, modified version of Teachers Sense of Teacher Efficacy Scale, Tschannen-Moran, Woolfolk Hoy, 2001) was filled in by all pre-school teachers which were in time of research employed in pre-school institution in Labin, Pazin, Porec and Pula (spring 2004). Data is presented by descriptive and factor analysis, especially for the aspect of competence (one factor) and attitudes (two factors). Results imply relative high perception of self-competence was found in most of participants. Competence is seen as a part of regular activities in pre-school surroundings, in»uenced by most knowledge and skills of teachers (design of different child activities, additional explanation and examples of subjects children do not understand, motivating children...). Lack of competence is more frequent in the field of positive development promotion and prevention of child risk behavior (motivating children with no interest for work, using strategies for advancement monitoring, helping parents with advice how to support their children in skill mastering, using calming down techniques when children are to loud or obstructing work). Regarding the results on the attitudes field, involved pre-school teachers perceive parents and families like responsible ones who could do more. To conclude, this paper stresses the importance of permanent pre-school teachers' education to help them to contribute to mental health and disorder and child risk behavior prevention with the work in regular pre-school curriculum.
Physically unclonable function using CMOS breakdown position (2017)

A novel physically unclonable function (PUF) utilizing the intrinsic randomness of oxide breakdown (BD) positions in CMOS transistors is presented. The advantages of this approach are studied and validated by measurements on test-chips fabricated in a commercial 40nm CMOS process. Experiments show that the required soft BDs can be reliably generated in a sufficiently short period. The randomness of the utilized mechanism shows excellent properties, required for PUF applications: an overall bias of 0.498 and inter-chip hamming distance (HD) of 0.501. Further analysis of the current distributions reveals a dependence of operating voltage on readout resolution and window. Finally, dedicated experiments with external heating and embedded poly-heaters show that these soft BDs are stable and show no read-out errors up to operating temperatures of 600K.
Kinetics of heterogeneous mercury reactions with sorbent particles: In situ capture methodologies (1999)

A previous study had reported the effectiveness of the in-situ generated TiO{sub 2} sorbent for Hg capture in combustion environments. A system consisting of a photochemical reaction cell was used to evaluate the kinetic parameters, such as reaction order, rate constant for the photooxidation of elemental mercury by TiO{sub 2}. TiO{sub 2} particles generated by an aerosol route and commercially available TiO{sub 2} powders were used in a fixed bed reactor system. As reported previously, no homogeneous gas phase oxidation of mercury was observed under a wide range of temperatures ranging from 400 to 1,300 degrees C. Capture of Hg by adsorption in the absence of UV irradiation was not observed. Only in the presence of UV irradiation, the sites on the titania surface were activated, and the gas phase Hg was adsorbed and oxidized on the surface (chemisorption). Under UV irradiation, the rate of Hg oxidation was evaluated as a function of Hg concentration, UV intensity, and available surface area (activated sites). The reaction orders with respect to the gas phase mercury concentration ({alpha}) and the UV intensity ({beta}) were found to be 1.40--0.1 and 0.35--0.05, respectively, for the case of fixed bed reactor system using Degusa P25 andmore » aerosol route generated TiO{sub 2}. For the case of in situ generated TiO{sub 2} particles, the {alpha} and {beta} are found to be 1.1--0.1 and 0.390, respectively. Results from the experiments at various photooxidation temperatures indicate that there are two regimes: a surface reaction controlling regime, E{sub a} = 10.77 kJ/mol/K, and an adsorption controlling regime, E{sub a} = {minus}25.96 kJ/mol/K. The experimentally observed rate constant, k{sub exp}, was 1.84H 10{sup {minus}9} Aexp({minus}1,295.24/T)[(m{sup 2}/g){sup {minus}1}({micro}g/m{sup 3}){sup {minus}1} ({micro}W/cm{sup 2}){sup {minus}0.39}(sec){sup {minus}1}] and 1.24 H 10{sup {minus}9} Aexp(3122.28/T) [(m{sup 2}/g){sup {minus}1}({micro}g/m{sup 3}){sup {minus}1}({micro}W/cm{sup 2}){sup {minus}0.39}(sec){sup {minus}1}] for the positive E{sub a} regime and the negative E{sub a} regime, respectively.« less
An Active Variant of Staphylococcal Nuclease Containing Norleucine in Place of Methionine (1969)

Abstract A methionine auxotroph of Staphylococcus aureus was grown with limiting methionine in the presence of a large excess of l-norleucine. Extracellular nuclease was produced that contained significant amounts of the latter amino acid. Treatment of such enzyme preparations with CNBr destroyed methionine-containing nuclease. The residual enzyme exhibited essentially normal activity, and it contained norleucine residues in place of the usual methionine residues.
Diastereoselective Pictet–Spengler reactions of<scp>L</scp>-(Boc)phenylalaninal and<scp>L</scp>-(Boc)prolinal: biomimetic syntheses of eudistomin T and (–)-woodinine (1994)

The diastereoselective Pictet–Spengler reaction of L-(Boc)phenylalaninal with tryptamine and the elaboration of this intermediate to the antibacterial compound eudistomin T and analogues of the antileukaemic compound eudistomidin B are described. We also report an efficient synthesis of the naturally occurring alkaloid (–)-woodinine from L-(Boc)prolinal and 5-bromotryptamine in three steps, using a diastereoselective Pictet–Spengler reaction. This approach affords, in addition, formal syntheses of the marine alkaloids eudistomins H and I.
Efficient retrieval of composite multimedia objects in the <i>JINSIL</i> distributed system (1997)

In a distributed environment, presentation of structured, composite multimedia information poses new challenges in dealing with variable bandwidth (BW) requirement and synchronization of media data objects. The detailed knowledge of BW requirement obtained by analyzing the document structure can be used to create a prefetch schedule that results in efficient utilization of system resources. A distributed environment consists of various system components that are either dedicated to a client or shared across multiple clients. Shared system components could benefit from Fine Granularity Advanced Reservation (FGAR) of resources based on true BW requirement. Prefetching by utilizing advance knowledge of BW requirement can further improve resource utilization. In this paper, we describe the JINSIL retrieval system that takes into account the available bandwidth and buffer resources and the nature of sharing in each component on the delivery path. It reshapes BW requirement, creates prefetch schedule for efficient resource utilization in each component, and reserves necessary BW and buffer. We also consider good choices for placement of prefetch buffers across various system components.