gebhart/patrepeval huggingface dataset:
Antitumor Agents. 211. Fluorinated 2-Phenyl-4-quinolone Derivatives as Antimitotic Antitumor Agents (2001)

Fluorinated 2-phenyl-4-quinolone derivatives were synthesized and evaluated in National Cancer Institute's 60 human tumor cell line in vitro screen. From the results, the ketone moiety plays an essential role in activity. Among the compounds tested, 2'-fluoro-6-pyrrol-2-phenyl-4-quinolone (13) exhibited the most potent cytotoxic activities (log GI(50) < -8.00) against renal and melanoma tumor cell lines. Compound 13 was also a potent inhibitor of tubulin polymerization (IC(50) = 0.46 microM) and of radiolabeled colchicine binding to tubulin, with activities comparable to those of the potent antimitotic natural products colchicine, podophyllotoxin, and combretastatin A-4.
DS data server: sharing fusion-energy data and results (2002)

Recent years have see an upsurge in inter-laboratory collaboration within the fusion community. Also, increasingly powerful and inexpensive workstations, linked together by Local Area Networks and through the Internet, have become available for data analysis. It has therefore become essential to provide a mechanism for getting data from a central facility computer to application programs running on a diverse assortment of workstations and larger computers, both locally and at remote sites. The Data Server (DS) protocol defines a client/server communication standard to help satisfy this need. The protocol, a joint development project between PPPL and ORNL, was designed specifically to handle the type of experimental data (separate shot numbers, diagnostic specific) generated by the fusion energy community. It provides a flexible, machine-independent standard for network access to remotely stored data. Subroutines within the local data-access library, while retaining the same outward appearance, are modified to include client code for network data access. Through normal library calls, a user application transparently connects with an experiment-specific Server via TCP/IP over a Local Area Network or through the Internet. The server program presents its local data to the network client following protocol standards. By simple, well-defined request/reply transactions, the client (library routine) gets the information necessary for its normal operation. The network communication is entirely hidden from the user.
Numerical recipes: example book (Pascal) (1986)

Designed to accompany Numerical Recipes in Pascal the example book provides listings of demonstration programs (source code) that illustrate the use of each Pascal procedure found in the main book. This book will be a valuable aid to users wishing to incorporate Pascal programs into their own applications programs and to conduct simple validation tests. The programs found in this book are different from the original example book in Pascal (which will be phased out). Furthermore, they are not compatible with the Pascal programs found in the appendix of the original (FORTRAN) version of Numerical Recipes. The Pascal appendix is being dropped from the FORTRAN book with the publication of Numerical Recipes in Pascal. The revised example diskette contains the machine-readable source code for the programs found in the revised example book. (It only contains the programs; it does not contain any text found in the book.) N.B. The diskette that accompanies the revised example book replaces the extant Numerical Recipes Example Diskette (Pascal). The revised diskette is only compatible with the programs listed in the revised example book.
An optical probe for accurately measuring displacements of a reflecting surface (1957)

The probe described is capable of accurately measuring the displacement of a plane reflecting surface along its normal without making mechanical contact with it. The image of an illuminated grating of special construction is formed on the surface to be observed, and the light reflected from this surface then forms an image of equal size on a second, exactly similar, grating. The disposition of the second image relative to the second grating depends upon the position of the probe relative to the plane surface and changes in this disposition cause variations in the amount of light transmitted which are detected photoelectrically. It is therefore possible to set the probe at a reproducible distance from ther eflecting surface by moving it until a predetermined level of light transmission is reached. Successive settings relative to a fixed surface indicate that the standard deviation of a single setting of the particular probe described is about 0.4 μ (1.6 × 10-5 in.). When the probe is used with a calibrated line standard, displacements may be measured with a standard deviation of 0.7 μ (2.8 × 10-5 in.).
6％羟乙基淀粉（130／0．4）用于III期急性患者液体复苏：一项最新系统评价和荟萃分析 (2013)

背景近期研究提示，6％羟乙基淀粉（hydroxyethyl starch，HES）130／0．4是全世界最常用的复苏液体之一，但由于有关HES的一些应用研究被撤回，使得再次评估其安全性和有效性成为必要之举。方法我们对未被撤回的随机对照试验进行了系统性回顾和荟萃分析，针对6％HES130／0．4与其他胶体液或晶体液对急性疾病或围术期死亡率、急性肾损伤（或肾衰竭）和出血的影响加以比较，并分析了被撤回研究数据在内的敏感性。结果共有粥项研究2149例研究对象符合纳入标准，不幸的是，其中11项研究（rl=541）已被撤回，剩余25项研究中的17项存在高危偏倚。未被撤回的研究中有J9项（n=1246）的研究对象为围术期患者，6项（n=362）研究针对危重症患者。，6项研究报道了死亡率，1184例研究对象中有104例死亡病例，死亡相对风险为0．95（95％可信区间0．64-1.42，I2=0％，P=0．73）；再加上被撤回研究中的14例死亡病例，则总体死亡相对风险为0．92（95％可信区间0．63-1.34，I2=0％，P=0．95）。有关急性肾损伤、红细胞输注和出血的资料数量有限且质量较差，不能进行荟萃分析。结论目前，已发表的文献质量较差，且报道的指标过少不足以准确评估输注6％HES130／0．4的利弊。无论纳入还是剔除被撤回的研究结果，所得结论一致。鉴于6％HES130／0．4已得到广泛使用，目前迫切需要评估指标完善、质量过关的试验对其应用加以支持。
Single-order transmission diffraction gratings based on dispersion engineered all-dielectric metasurfaces (2016)

A single-order transmission diffraction grating based on dispersion engineered all-dielectric metasurfaces is proposed, and its wavelength discriminating properties have been theoretically described and confirmed using numerical simulations. The metasurface is designed using a 2D array of all-dielectric resonators, which emulates a Huygens' source configuration to achieve a perfect match to free space in broad bandwidth. Using a holey dielectric nanodisk structure as the unit cell, the resonant wavelength is tapered across the metasurface to engineer the wavelength-dependent spatial phase gradient, to emulate a dispersive prism. Consequently, different wavelengths are steered toward different directions and thus are discriminated on the output image plane. Due to the subwavelength periodicities involved, wavelength discrimination is achieved directly in the zeroth diffraction order of the device, unlike conventional diffraction gratings, thereby providing a high-efficiency wavelength discriminating device.
Generating test inputs for embedded control systems (2003)

Embedded control systems are growing rapidly, and there is a need for short design cycles. As a result, there is increasing interest in effective methods for automatic test generation. The authors present a new method for leveraging existing simulation models, involving genetic algorithms, for embedded control system designs to generate test inputs automatically, thereby eliminating the time-consuming task of creating them manually.
Electronically tunable single-mode external-cavity diode laser (1991)

A six-stage birefringent filter placed in an external cavity of an AlGaAs diode laser is used to scan the laser electronically over 10.3 nm, hopping single modes of the external cavity. Continuous electronic tuning of the single mode over the free spectral range of the external cavity, 182 MHz, is also demonstrated by using a variable-phase plate. All tuning mechanisms use nematic liquid-crystal electro-optic effects operating at <2 V.
New Generation of Artificial MicroRNA and Synthetic Trans-Acting Small Interfering RNA Vectors for Efficient Gene Silencing in Arabidopsis (2014)

Artificial microRNAs (amiRNAs) and synthetic trans-acting small interfering RNAs (syn-tasiRNAs) are used for small RNA-based, specific gene silencing or knockdown in plants. Current methods to generate amiRNA or syn-tasiRNA constructs are not well adapted for cost-effective, large-scale production or for multiplexing to specifically suppress multiple targets. Here, we describe simple, fast, and cost-effective methods with high-throughput capability to generate amiRNA and multiplexed syn-tasiRNA constructs for efficient gene silencing in Arabidopsis (Arabidopsis thaliana) and other plant species. amiRNA or syn-tasiRNA inserts resulting from the annealing of two overlapping and partially complementary oligonucleotides are ligated directionally into a zero background BsaI/ccdB-based expression vector. BsaI/ccdB vectors for amiRNA or syn-tasiRNA cloning and expression contain a modified version of Arabidopsis MIR390a or TAS1c precursors, respectively, in which a fragment of the endogenous sequence was substituted by a ccdB cassette flanked by two BsaI sites. Several amiRNA and syn-tasiRNA sequences designed to target one or more endogenous genes were validated in transgenic plants that (1) exhibited the expected phenotypes predicted by loss of target gene function, (2) accumulated high levels of accurately processed amiRNAs or syn-tasiRNAs, and (3) had reduced levels of the corresponding target RNAs.
3‐D description of normal moveout in anisotropic media (1996)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 19963‐D description of normal moveout in anisotropic mediaAuthors: Vladimir GrechkaNya TsvankinVladimir GrechkaCenter for Wave Phenomena, Department of Geophysics, Colorado School of Mines and Nya TsvankinCenter for Wave Phenomena, Department of Geophysics, Colorado School of Mineshttps://doi.org/10.1190/1.1826398 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1826398FiguresReferencesRelatedDetailsCited ByOptimization of Nonhyperbolic Moveout Correction Equation of Long-Offset Seismic Data in VTI Media31 May 2013 | Chinese Journal of Geophysics, Vol. 49, No. 6Explicit analytic expression for normal moveout from horizontal and dipping reflectors in weakly anisotropic media of arbitrary symmetry typeP. N. J. Rasolofosaon7 February 2012 | GEOPHYSICS, Vol. 65, No. 4Fracture detection in a carbonate reservoir using a variety of seismic methodsMaria A. Pérez, Vladimir Grechka, and Reinaldo J. Michelena7 February 2012 | GEOPHYSICS, Vol. 64, No. 4Nonhyperbolic reflection moveout for horizontal transverse isotropyAbdulFattah Al‐Dajani and Ilya Tsvankin7 February 2012 | GEOPHYSICS, Vol. 63, No. 5Misalignment of the orientation of fractures and the principal axes for P and S waves in rocks containing multiple non-orthogonal fracture setsGeophysical Journal International, Vol. 133, No. 2Feasibility of nonhyperbolic moveout inversion in transversely isotropic mediaVladimir Grechka and Ilya Tsvankin7 February 2012 | GEOPHYSICS, Vol. 63, No. 3Normal moveout velocities in 3D arbitrary anisotropic mediaDirk Gajewski, Boris Kashtan, and Matthias Zillmer10 February 2005 SEG Technical Program Expanded Abstracts 1996ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1996 Pages: 2106 publication data© 1996 Copyright © 1996 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 10 Feb 2005 CITATION INFORMATION Vladimir Grechka and Nya Tsvankin, (1996), "3‐D description of normal moveout in anisotropic media," SEG Technical Program Expanded Abstracts : 1487-1490. https://doi.org/10.1190/1.1826398 Plain-Language Summary PDF DownloadLoading ...
A guide to the treatment of adults with ADHD. (2004)

While child and adolescent physicians are familiar with the treatment of attention-deficit/hyperac-tivity disorder (ADHD), many adult physicians have had little experience with the disorder. It is difficult to develop clinical skills in the management of residual adult manifestations of developmental disorders without clinical experience with their presentation in childhood. Adult patients are increasingly seeking treatment for the symptoms of ADHD, and physicians need practice guidelines. Adult ADHD often presents differently from childhood ADHD. Because adult ADHD can be comorbid with other disorders and has symptoms similar to those of other disorders, it is important to understand differential diagnoses. Physicians should work with patients to provide feedback about their symptoms, to educate them about ADHD, and to set treatment goals. Treatment for ADHD in adults should include a medication trial, restructuring of the patient's environment to make it more compatible with the symptoms of ADHD, and ongoing supportive management to address any residual impairment and to facilitate functional and developmental improvements.
MOSAIC: Multiple Overlay Selection and Intelligent Composition (2007)

Today, the most effective mechanism for remedying shortcomings of the Internet, or augmenting it with new networking capabilities, is to develop and deploy a new overlay network. This leads to the problem of multiple networking infrastructures, each with independent advantages, and each developed in isolation. A greatly preferable solution is to have a single infrastructure under which new overlays can be developed, deployed, selected, and combined according to application and administrator needs.\nMOSAIC is an extensible infrastructure that enables not only the specification of new overlay networks, but also dynamic selection and composition of such overlays. MOSAIC provides declarative networking: it uses a unified declarative language (Mozlog) and runtime system to enable specification of new overlay networks, as well as their composition in both the control and data planes. Importantly, it permits dynamic compositions with both existing overlay networks and legacy applications. This paper demonstrates the dynamic selection and composition capabilities of MOSAIC with a variety of declarative overlays: an indirection overlay that supports mobility (i3), a resilient overlay (RON), and a transport-layer proxy. Using a remarkably concise specification, MOSAIC provides the benefits of runtime composition to simultaneously deliver application-aware mobility, NAT traversal and reliability with low performance overhead, demonstrated with deployment and measurement on both a local cluster and the PlanetLab testbed.
Fatigue in Chronic Migraine Patients (2002)

Fatigue is a common symptom frequently reported in many disorders including headaches, but little is known about its nature. The objective was to determine the prevalence of fatigue in chronic migraine (CM) patients, to define its subtypes and its relationship with other conditions comorbid with CM. Sixty-three CM patients were analysed. The Fatigue Severity Scale (FSS), the Chalder fatigue scale and the CDC diagnostic criteria for chronic fatigue syndrome (CFS) were used. Fifty-three (84.1%) patients had FSS scores greater than 27. Forty-two (66.7%) patients met the CDC criteria for CFS. Thirty-two patients (50.8%) met the modified CDC criteria (without headache). Beck depression scores correlated with FSS, mental and physical fatigue scores. Trait anxiety scores also correlated with fatigue scales. Women had higher FSS scores than men, P < 0.05. Physical fatigue was associated with fibromyalgia, P < 0.05. Fatigue as a symptom and CFS as a disorder are both common in CM patients. Therapeutic interventions include a graded aerobic exercise program, cognitive behavioural therapy and antidepressants. Identification of fatigue and its subtypes in headache disorders and recognition of headaches in CFS patients has implications for the pathophysiology, diagnosis and treatment of these disorders.
Modelling network and system monitoring over the Internet with mobile agents (2002)

Distributed Network Management is gaining importance due to the explosive growth of the size of computer networks. New management paradigms are being proposed as an alternative to the centralised one, and new technologies and programming languages are making them feasible. The use of Mobile Agents (MAs) to distribute and delegate management tasks is a particularly promising approach to dealing with the limitations of current centralised management systems which appear to be lacking flexibility and scalability. This paper is focused on the impact that mobile code paradigms can have on distributed network and system monitoring. A dynamic, hierarchical management model based on a delegation paradigm is adopted and an MA-architecture for monitoring operations is proposed. Finally, possible uses of the proposed model and architecture for pursuing seamless and timely monitoring are discussed.
Temperature-aware voltage islands architecting in system-on-chip design (2006)

As technology scales, power consumption and thermal effects have become challenges for system-on-chip designers. The rising on-chip temperatures can have negative impacts on SoC performance, power, and reliability. In view of this, we present a hybrid optimization approach which aims at temperature reduction and hot spot elimination. We demonstrate that considerable improvement in the thermal distribution of a design can be achieved through careful voltage island partitioning, voltage level assignment, and voltage island floorplanning. The experimental results on MCNC benchmarks show significant improvement on the thermal profiles. To the best of our knowledge, this is the first work to explore the thermal impacts of voltage islands.
Computer analysis of the electrocardiogram during esophageal pacing cardiac stress (1991)

It has been estimated that 15 to 30% of patients with suspected or known coronary artery disease are unable to perform an adequate exercise stress test due to a variety of reasons such as obesity, poor physical condition, claudication, etc. Transesophageal atrial pacing has been proposed as a noninvasive alternative for inducing cardiac stress in patients who cannot exercise. Although computer analysis is commonly employed to analyze the electrocardiogram (ECG) during the conventional exercise stress test, the surface ECG recorded during transesophageal atrial pacing is contaminated with large pacing artifacts which confound beat identification by standard computer software. We report the development of a robust signal processing algorithm for interpretation of the surface ECG during transesophageal atrial pacing stress. The algorithm employs novel schemes using both linear and nonlinear transformations to detect and differentiate between the pacing artifact and QRS complex even in difficult situations where the pacing artifact is in proximity to or superimposed on the QRS complex. The algorithm uses sophisticated logic for automatic recognition of sustained capture. It subsequently calculates beat-by-beat and average (over five beats) ST segment amplitude and slope. The algorithm also reports the instantaneous heart rate, RR interval, pace-to-R interval, R-wave amplitude, and estimated sinus node recovery time upon loss of sustained capture. The limitations of present exercise ECG computer methods in processing the ECG during transesophageal atrial pacing stress are evaluated and significantly improved performance by our algorithm is demonstrated.
Optimization of heterologous production of the polyketide 6‐MSA in <i>Saccharomyces cerevisiae</i> (2006)

Polyketides are a group of natural products that have gained much interest due to their use as antibiotics, cholesterol lowering agents, immunosuppressors, and as other drugs. Many organisms that naturally produce polyketides are difficult to cultivate and only produce these metabolites in small amounts. It is therefore of general interest to transfer polyketide synthase (PKS) genes from their natural sources into heterologous hosts that can over-produce the corresponding polyketides. In this study we demonstrate the heterologous expression of 6-methylsalicylic acid synthase (6-MSAS), naturally produced by Penicillium patulum, in the yeast Saccharomyces cerevisiae. In order to activate the PKS a 4'-phosphopantetheinyl transferase (PPTase) is required. We therefore co-expressed PPTases encoded by either sfp from Bacillus subtilis or by npgA from Aspergillus nidulans. The different strains were grown in batch cultures. Growth and product concentration were measured and kinetic parameters were calculated. It was shown that both PPTases could be efficiently used for activation of PKS's in yeast as good yields of 6-MSA were obtained with both enzymes.
Design and implementation of software framework for software defined radio system (2003)

It is expected that multiple radio access standards and systems will coexist in the same environment beyond 3G. The superior re-configurability and re-programmability of software-defined radio (SDR) had made itself become the most promising technology to realize such a flexible radio system. Several research projects have involved in the development of SDR systems, but their efforts mainly focus on hardware design. A software framework that allows users, manufactures or operators to insert, remove, update and configure protocols, applications and hardware modules is also an essential part of a SDR system. Unfortunately, current commercial operating systems (OS) lack of fully supports of SDR features. In this paper, the impacts of SDR on the OS and the extension of the OS for a SDR system are investigated. Moreover, the design and implementation of a software framework based on a commercial on-the-shelf (COTS) OS are also presented.
Human Group B Rotavirus Infections Cause Severe Diarrhea in Children and Adults in Bangladesh (2003)

Human group B rotavirus was detected in 12 of 220 adult patients and 2 of 67 child patients with severe diarrhea in Bangladesh. Group B rotavirus may be virulent in both adults and children, and the virus may be an especially serious diarrheal agent in Bangladesh.
Mer-NF5003B, E and F, novel sesquiterpenoids as avian myeloblastosis virus protease inhibitors produced by Stachybotrys sp. (1994)

Aspartic retroviral proteases play an important role in the processing of viral polyproteins into
Cytology of human early implantation. (1976)

The human embryo is present in the uterus as early as 3 1/2 days after ovulation. The human blastocyst has as many as 186 cells prior to implantation. The postimplantation blastocyst is already producing human chorionic gonadotropin by about 9 days after ovulation and has penetrated the vessels of the endometrium. It is possible that lytic enzymes associated with the cell surface of the trophoblast or released in its vicinity aid penetration. Tongues of trophoblast penetrate between adjacent uterine epithelial cells thus anchoring the trophoblast and aiding organization of the implantation site. In the rabbit the trophoblast incorporates uterine cells by fusing with them. In the human phagocytosis is more likely than cell fusion. The initial implantation stages precede any decidualization of the uterine stroma. Schematic drawings illustrate the process.