gebhart/patrepeval huggingface dataset:
Interaction of a polyamine analogue, 1,19-bis-(ethylamino)-5,10,15- triazanonadecane (BE-4-4-4-4), with DNA and effect on growth, survival, and polyamine levels in seven human brain tumor cell lines. (1993)

Computer graphics modeling and physicochemical studies of spermine-DNA interactions, as well as experiments in cell culture, indicate that a polyamine analogue with strong affinity for nucleic acids but poor ability to condense and aggregate DNA in vitro should act as an antiproliferative agent if it can enter cells. On the basis of our studies of polyamine-DNA interactions, we designed a pentamine, 1,19-bis(ethylamino)-5,10,15- triazanonadecane (BE-4-4-4-4), that had these characteristics. Measurement of melting temperature and ultraviolet light scattering studies show that the affinity of this analogue for calf-thymus DNA is about 4 times higher than that of spermine, whereas its ability to aggregate DNA is slightly poorer than that of spermine. Studies in U-87 MG, U-251 MG, SF-126, SF-188, SF-763, SF-767, and DAOY human brain tumor cells in tissue culture showed that treatment for more than 96 h with concentrations of 5 microM BE-4-4-4-4 or greater inhibited growth; decreased levels of putrescine, spermidine, and spermine; and decreased colony-forming ability in all cell lines. The cytotoxicity of the analogue varied among cell lines; DAOY and SF-767 were the most sensitive and the most resistant lines, respectively. In SF-763 cells, growth inhibition by BE-4-4-4-4 could be partially reversed by the addition of putrescine, spermidine, or spermine 1 day after BE-4-4-4-4 addition, but in U-251 MG cells, growth inhibition was reversed only by spermine and not by other polyamines. When any of the naturally occurring polyamines was added simultaneously with BE-4-4-4-4, growth inhibition was completely blocked. The data suggest that a threshold intracellular concentration of BE-4-4-4-4 is needed to manifest the growth-inhibitory and cytotoxic effects. In most cell lines, once that threshold level is reached, the growth-inhibitory and cytotoxic properties of the analogue are manifest irrespective of cellular polyamine levels. Further increases in the BE-4-4-4-4 concentration or incubation time reduce the intracellular polyamine levels but do not significantly increase growth inhibition. In U-87 MG and DAOY cells, however, prolonged incubation with higher concentrations of BE-4-4-4-4 causes additional growth inhibition along with depletion of intracellular polyamines.(ABSTRACT TRUNCATED AT 400 WORDS)
Computer Simulation of Plasma Insulin and Glucose Dynamics After Subcutaneous Insulin Injection (1989)

We developed a computer program for the simulation of plasma insulin and glucose dynamics after subcutaneous injection of insulin. The program incorporates a pharmacokinetic model to calculate the time courses of plasma insulin for various combinations of popular preparations (regular, NPH, lente, and ultralente). With the use of a pharmacodynamic model describing the dependence of glucose dynamics on plasma insulin and glucose levels, the program can predict the expected time course of plasma glucose in response to a change in carbohydrate intake, insulin dose, timing, or regimen. A set of typical parameters has been obtained by analysis of data from the literature. The results of several computer simulations are presented showing the effect on a 24-h insulin and glucose profile of systematically changing insulin regimen, dose, timing of meals, or timing of preprandial insulin administration. The program can be used to explore on a theoretical basis the impact of various factors associated with glycemic control in insulin-dependent diabetes mellitus. As an educational tool, the program provides a realistic environment for demonstration of the combined or isolated effects of insulin and diet on glycemia.
EFFECT OF EXPERIMENTAL CONDITIONS AND SOLVENTS ON THE PRECIPITATION AND COMPOSITION OF ASPHALTENES (2001)

Abstract The ASTM D 3279 test method for “n-Heptane Insolubles” is being currently used to determine the asphaltene content of fuel oils as defined by insolubility in normal (n) heptane solvent. Precipitation of n-heptane insolubles can produce sediments which vary in color, morphology and composition. The SEM analysis of n-heptane insolubles indicated that the sediments were heterogeneous containing some large particles >300 μ and the majority of particles to be small, <10 μ, “chained” together forming agglomerates. Significant fractions of n-heptane insolubles were found insoluble in toluene indicating their non-asphaltenic nature (“solids”). FTIR and XRF analyses of “solids” indicated the presence of multiring aromatics, Ni and carboxylate and sulfate salts. FTIR analysis of toluene soluble asphaltenes showed the presence of multiring aromatics. GC/MS analysis of toluene soluble asphaltenes indicated desorption of alkylbenzenes and O-containing molecules but no desorption of N- and S-containing molecules was observed. The tendency for N- and S-containing molecules to remain in the nonvolatile residue during the GC/MS analysis indicates that the N- and S-containing compounds have higher stability. The XRF analysis of the toluene soluble asphaltenes indicated that the molecules are similar to asphaltenes found in crude oils in terms of C, H, N and S contents, however, no presence of V- and Ni-containing molecules was found. Acknowledgments
Surface Generated Acoustic Wave Biosensors for the Detection of Pathogens: A Review (2009)

This review presents a deep insight into the Surface Generated Acoustic Wave (SGAW) technology for biosensing applications, based on more than 40 years of technological and scientific developments. In the last 20 years, SGAWs have been attracting the attention of the biochemical scientific community, due to the fact that some of these devices - Shear Horizontal Surface Acoustic Wave (SH-SAW), Surface Transverse Wave (STW), Love Wave (LW), Flexural Plate Wave (FPW), Shear Horizontal Acoustic Plate Mode (SH-APM) and Layered Guided Acoustic Plate Mode (LG-APM) - have demonstrated a high sensitivity in the detection of biorelevant molecules in liquid media. In addition, complementary efforts to improve the sensing films have been done during these years. All these developments have been made with the aim of achieving, in a future, a highly sensitive, low cost, small size, multi-channel, portable, reliable and commercially established SGAW biosensor. A setup with these features could significantly contribute to future developments in the health, food and environmental industries. The second purpose of this work is to describe the state-of-the-art of SGAW biosensors for the detection of pathogens, being this topic an issue of extremely importance for the human health. Finally, the review discuses the commercial availability, trends and future challenges of the SGAW biosensors for such applications.
30. The action of the oppenauer reagent on primary alcohols, including vitamin-A (1938)

J. W. Batty, A. Burawoy, S. H. Harper, I. M. Heilbron and W. E. Jones, J. Chem. Soc., 1938, 175 DOI: 10.1039/JR9380000175
Pituitary extract causes aggregation and differentiation of rat mammary tumor MTW9/Pl cells (1992)

Alkaline pituitary extracts (PE) of the mammosomatotropic tumor MtTW10 differentiated cultured PRL-independent rat mammary tumor cells MTW9/Pl. Within 24 h, MTW9 cells growing in suspension began to aggregate and adhere to the plastic dish. Cultured dispersed MTW9 cells were undifferentiated, but PE treatment resulted in organoid aggregates that exhibited glandular luminal structures and periodic acid-Schiff-positive material consistent with basement membrane formation. Morphometric examination of organoids demonstrated a reduction in nuclear and cell perimeters compared to those of untreated cells. Electron microscopy showed that the treatment resulted in polarization, nuclear changes, junctional complexes, secretory spaces, microvilli, and basement membrane formation. A disaggregated undifferentiated tumor now appeared as a differentiated adenocarcinoma. PE induced expression of laminin and milk protein, but failed to increase fibronectin expression. Extracts of MTOM (a variant of MtTW10 which secretes little PRL) and bovine pituitary also produced aggregation and adhesion of MTW9. A number of tissue extracts, growth factors, and hormones failed to produce such aggregation. Laminin, but not fibronectin, produced aggregation and adhesion similar to those produced by PE. Cycloheximide inhibited the aggregation effect of PE, but not that of laminin. PE was mitogenic for MTW9, but inhibition of proliferation by vinblastine did not inhibit the aggregation induced by PE. These observations suggest that the pituitary contains a novel factor that stimulates matrix synthesis, resulting in differentiation, possibly laminin induced.
Unsupervised domain adaptation for robust speech recognition via variational autoencoder-based data augmentation (2017)

Domain mismatch between training and testing can lead to significant degradation in performance in many machine learning scenarios. Unfortunately, this is not a rare situation for automatic speech recognition deployments in real-world applications. Research on robust speech recognition can be regarded as trying to overcome this domain mismatch issue. In this paper, we address the unsupervised domain adaptation problem for robust speech recognition, where both source and target domain speech are available, but word transcripts are only available for the source domain speech. We present novel augmentation-based methods that transform speech in a way that does not change the transcripts. Specifically, we first train a variational autoencoder on both source and target domain data (without supervision) to learn a latent representation of speech. We then transform nuisance attributes of speech that are irrelevant to recognition by modifying the latent representations, in order to augment labeled training data with additional data whose distribution is more similar to the target domain. The proposed method is evaluated on the CHiME-4 dataset and reduces the absolute word error rate (WER) by as much as 35% compared to the non-adapted baseline.
Preliminary Experience and Extended Applications for the Use of Autologous Platelet-Rich Plasma in Hair Transplantation Surgery (2007)

The use of platelet rich plasma (PRP) in hair restoration surgery reported increased yield when utilized as a graft storage medium (Uebel, 2005).[1][1] When grafts are bathed in activated PRP, there appears to be higher graft survival and quicker healing. Based on five months of experience
Speech and Hearing in Communication. (1953)

Physics of sound, as applied to speech and hearing, was advanced considerably by the publication of the first edition of "Speech and Hearing" in 1929. Written by a physicist who had devoted 15 years to research in the transmission of sound at the Bell Telephone Company laboratories, the book proved to be an authoritative source of information on acoustics and one on which much of the later research in communications was based. This new book of the same name, based on the author's earlier work, contains the most recent information on acoustics. The author discusses the physics of the speaking and hearing mechanisms of the human being. The fundamentals of acoustics and methods of calculating articulation scores are also presented. A new method for the calculation of perception of speech and a method for computing per cent hearing loss are proposed. The book deals extensively with the mathematical approach to
Organic Working Fluids for a Combined Power and Cooling Cycle (2005)

A new thermodynamic cycle has been developed for the simultaneous production of power and cooling from low-temperature heat sources. The proposed cycle combines the Rankine and absorption refrigeration cycles, providing power and cooling as useful outputs. Initial studies were performed with an ammonia-water mixture as the working fluid in the cycle. This work extends the application of the cycle to working fluids consisting of organic fluid mixtures. Organic working fluids have been used successfully in geothermal power plants, as working fluids in Rankine cycles. An advantage of using organic working fluids is that the industry has experience with building turbines for these fluids. A commercially available optimization program has been used to maximize the thermodynamic performance of the cycle. The advantages and disadvantages of using organic fluid mixtures as opposed to an ammonia-water mixture are discussed. It is found that thermodynamic efficiencies achievable with organic fluid mixtures, under optimum conditions, are lower than those obtained with ammonia-water mixtures. Further, the refrigeration temperatures achievable using organic fluid mixtures are higher than those using ammonia-water mixtures.
A Study of New Highly Efficient MPPT Control Algorithm (2002)

This paper proposed a MPPT(Maximum Power Point Tracking) control algorithm for PV(Photovoltaic) array based on a modified constant voltage control MPPT algorithm at low insolation. This method which combined a reference voltage control and a constant voltage control algorithm. In contrast to the typical conventional MPPT algorithm, the proposed method have been obtained high efficiency and good performance in all insolation intensity. The proposed algorithm is verified through simulation and experiment.
Intrusion detection in virtual machine environments (2004)

A virtual machine is a software replica of an underlying real machine. Multiple virtual machines can operate on the same host machine concurrently, without interfere each other. Such concept is becoming valuable in production computing systems, due to its benefits in terms of costs and portability. As they provide a strong isolation between the virtual environment and the underlying real system, virtual machines can also be used to improve the security of a computer system in face of attacks to its network services. This work presents a new approach to achieve this goal, by applying intrusion detection techniques to virtual machine based systems, thus keeping the intrusion detection system out of reach from intruders. The results obtained from a prototype implementation confirm the usefulness of this approach.
Facile synthesis of 3'-O-methylthymidine and 3'-deoxythymidine and related deoxygenated thymidine derivative: a new method for selective deoxygenation of secondary hydroxy groups (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFacile synthesis of 3'-O-methylthymidine and 3'-deoxythymidine and related deoxygenated thymidine derivative: a new method for selective deoxygenation of secondary hydroxy groupsMitsuo Sekine and Takeshi NakanishiCite this: J. Org. Chem. 1990, 55, 3, 924–928Publication Date (Print):February 1, 1990Publication History Published online1 May 2002Published inissue 1 February 1990https://pubs.acs.org/doi/10.1021/jo00290a024https://doi.org/10.1021/jo00290a024research-articleACS PublicationsRequest reuse permissionsArticle Views434Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Isolation and characterization of the genes for two small RNAs of herpesvirus papio and their comparison with Epstein-Barr virus-encoded EBER RNAs (1988)

Genes for the Epstein-Barr virus-encoded RNAs (EBERs), two low-molecular-weight RNAs encoded by the human gammaherpesvirus Epstein-Barr virus (EBV), hybridize to two small RNAs in a baboon cell line that contains a similar virus, herpesvirus papio (HVP). The genes for the HVP RNAs (HVP-1 and HVP-2) are located together in the small unique region at the left end of the viral genome and are transcribed by RNA polymerase III in a rightward direction, similar to the EBERs. There is significant similarity between EBER1 and HVP-1 RNA, except for an insert of 22 nucleotides which increases the length of HVP-1 RNA to 190 nucleotides. There is less similarity between the sequences of EBER2 and HVP-2 RNA, but both have a length of about 170 nucleotides. The predicted secondary structure of each HVP RNA is remarkably similar to that of the respective EBER, implying that the secondary structures are important for function. Upstream from the initiation sites of all four RNA genes are several highly conserved sequences which may function in the regulation of transcription. The HVP RNAs, together with the EBERs, are highly abundant in transformed cells and are efficiently bound by the cellular La protein.
An ASIC for transponder for radio frequency identification system (2002)

Presented is a novel and effective design of a batteryless, self-powered RFID transponder. It is compatible with the TIRIS, the popular RFID system by the Texas Instruments. Data transmission uses FSK modulation and the circuit is designed such that the output frequencies are implicitly determined, independent of the load of the antenna. The major part of the design uses digital CMOS circuit, thus simple and easy to implement. The chip layout is designed and fabricated in a 0.8 um CMOS SPDM n-well process. It occupies about 0.8 mm/spl times/0.8 mm die size.
High-Dose Ifosfamide Is Associated with Severe, Reversible Cardiac Dysfunction (1993)

High-dose ifosfamide is associated with severe but usually reversible myocardial depression and malignant arrhythmias.
Preparation of an isolated cutaneous infusion in sheep. (1982)

Cannulation of a branch of the deep circumflex iliac artery of sheep is described. This artery provides afferent cutaneous circulation (o a region (approximately 100 cm 2 ) over the caudal flank and cranial thigh. The preparation remained patent for four to six days. By allowing infusion of an isolated area of skin this technique provides a new dimension for studies designed to elucidate peripheral mechanisms involved in the physiology of wool growth and associated subjects.
2.7 A hybrid supply modulator with 10dB ET operation dynamic range achieving a PAE of 42.6% at 27.0dBm PA output power (2015)

Envelope tracking (ET) prolongs the battery life by modulating the supply of a power amplifier (PA) according to the signal envelope. With this emerging technology, the PA efficiency is greatly improved, whereas the supply modulator (SM) itself needs to provide efficient and accurate envelope tracking for the overall performance of the SM-PA combined system (PA module). The ET technique, meanwhile, has seen limited use in high-power transmission due to the reduced SM efficiency for low output power originating from the linear stage in hybrid structures [1].
Public Insurance and Mobility: An Exploratory Analysis in the Context of European Economic Unification (1997)

Many studies on the future of social security systems in a unified Europe treat the issue as merely a particular aspect of the broader question of redistribution within a federation with mobile agents. As a result, such studies typically recommend their gradual centralisation. This paper which is based on the model of Rothschild, Stiglitz and Wilson adopts a much less categorical approach, emphasising the need to clarify whether social security systems principally seek insurance or redistribution. In this analytical framework competition between public insurance systems can generate efficiency. It can also remain compatible with cross-subsidisation if the proportion of low risks is sufficiently large. The result depends on the relative proportion of high risks, on the goals of the national social security systems, and on their behaviour when competing with each over.
Detection of Weak Magnetic Fields Induced by Electrical Currents with MRI: Theoretical and Practical Limits of Sensitivity (2004)

Detection of weak magnetic fields induced by neuronal electrical activities with magnetic resonance imaging (MRI) is a potentially effective method for functional imaging of the brain. In this study, we compared the theoretical and practical limits of sensitivity for detecting weak magnetic fields with a columnar phantom. The theoretical limit of sensitivity was estimated from signal and noise intensities in magnetic resonance images. The theoretical limit of sensitivity was approximately 10(-8)T. The practical limit was 10 times the theoretical limit. The dependence of the theoretical limit of sensitivity on acquisition parameters, such as the repetition time (TR), echo time (TE), number of pixels, and spectral width, was quantitatively evaluated. The results indicated the existence of an optimal value in T(E)/T2*.
The four ages of early prestressed concrete structures (2014)

Unlike reinforced concrete, the history of prestressed concrete has been insufficiently studied. Little progress has been made on this matter since the first classical texts appeared in England, the U. S. and Germany soon after the Second World War and the life of Freyssinet was published after Spain returned to democracy. Some evidence of this gap is that some very well reputed textbooks on prestressed concrete, as well as recent and updated papers, still repeat those old chronologies. Although this trend occurs in some cases, some researchers have been making interesting and noteworthy advances in recent decades. Some of these advances are discussed here with new data pulled from the study of early patents on prestressed structures, and these resources are looked at from a new historical perspective: the four ages of prestressed concrete structures. Beyond application to concrete structures, this “four ages” perspective can also be useful for studying the history of prestressed structures made of other materials.
Delay-Tolerant Broadcasting (2007)

There are many asynchronous communication situations for which the prevalent continuous connectivity paradigm is not needed. Communication with a fair delay tolerance may instead be provided by intermittent store-and-forwarding between nodes. This paper proposes a design for an open, receiver-driven broadcasting system that relies on delay-tolerant forwarding of data chunks through mobility of wireless nodes. The system provides public broadcast channels, which may be openly used for both transmission and reception. We show by analysis and simulation under benchmark mobility models that a delay-tolerant broadcast channel has both a sufficiently high throughput and reach to be interesting as a competitive alternative to the regulated wireless broadcast channel. The analysis is based on a queuing model to study the interactions among the mobile nodes in a street. The simulations complement this analysis for mobile nodes moving on a square according to benchmark mobility models. Finally, we present the design of, and experiences with, a proof-of-concept prototype