gebhart/patrepeval huggingface dataset:
Fast Distributed Deep Learning via Worker-adaptive Batch Sizing (2018)

In heterogeneous or shared clusters, distributed learning processes are slowed down by straggling workers. In this work, we propose LB-BSP, a new synchronization scheme that eliminates stragglers by adapting each worker's training load (batch size) to its processing capability. For training in shared production clusters, a prerequisite for deciding the workers' batch sizes is to know their processing speeds before each iteration starts. To this end, we adopt NARX, an extended recurrent neural network that accounts for both the historical speeds and the driving factors such as CPU and memory in prediction.
Synthesis and structural characterization of a new polysiloxane with second‐order nonlinear optical effect (2004)

Abstract A new polysiloxane ( P2 ), with a high density of the indole‐based chromophore and carbazolyl side groups, was prepared. Thus a polysiloxane ( P1 ), with indole and carbazolyl groups as side chains, was first synthesized through a hydrosilylation reaction, and then the post‐azo coupling of p ‐nitrobenzenediazonium fluoroborate toward the indole ring gave the mulifunctional indole‐based chromophore‐functionalized polysiloxane ( P2 ). Molecular structural characterization for the polymers was determined by 1 H‐NMR, IR, and UV–visible spectra, gel permeation chromatography, and differential scanning calorimetry. The polymers were easily soluble in common organic solvents. The poled film of P2 revealed a resonant d 33 value of 27 pm/V by second‐harmonic generation measurements. © 2004 Wiley Periodicals, Inc. J Appl Polym Sci 94: 769–774, 2004
Manganese-dependent disproportionation of hydrogen peroxide in bicarbonate buffer. (1990)

At physiological concentrations of HCO3- and CO2, Mn(II) catalyzes disproportionation of H2O2. This catalase-like activity is directly proportional to the concentrations of Mn(II) and H2O2, and it increases exponentially with increases in pH. The effect of increasing pH is almost completely attributable to the concomitant increase in HCO3- concentration. The rate is proportional to the third power of the HCO3- concentration, suggesting that 3 equivalents of HCO3- combine with 1 equivalent of Mn(II) to form the catalytic complex. It is presumed that the redox potential of the Mn(II) in equilibrium with Mn(III) couple in such a complex permits H2O2 to carry out facile reactions with Mn(II) comparable to those that occur with Fe(III) and Cu(II) chelate complexes, in which OH. and O2-. are established intermediates. The Mn-catalyzed disproportionation of H2O2 does not occur at physiological pH in the absence of HCO3-. Hepes, inorganic phosphate, and inorganic pyrophosphate inhibit the reaction catalyzed by the Mn/HCO3- system. These results are similar to those of Sychev et al. [Sychev, A.Y., Pfannmeller, U. & Isak, V.G. (1983) Russ. J. Phys. Chem. 57, 1690-1693]. The catalase-like activity of Mn(II)-bicarbonate complexes reported here, together with the superoxide dismutase activity of Mn complexes demonstrated by Archibald and Fridovich [Archibald, F.S. & Fridovich, I. (1982) Arch. Biochem. Biophys. 214, 452-463], strengthen the proposition that Mn may play an important role in the protection of cells against oxygen radical-mediated damage.
Mathematics and Character Education (1936)

In this day of radio ballyhoo we have begun to develop thick hides, or a deaf ear, or whatever it takes to resist the persuasion of high-power, longrange, leather-lunged persuaders. We mistrust that eating Father's Bread will make our hair curly; we doubt the efficacy of wart removers, corn removers, stain removers; we are cynical about the merits of almost every proposition enthusiastically advanced. But every school teacher and his brother will surely pay attention when Dr. Cowley demonstrates, with quadratic logic and hardly a single P.E., the relationship between mathematics and character.
Fermentation of cacao (<i>Theobroma cacao</i>L.) seeds with a hybrid<i>Kluyveromyces marxianus</i>strain improved product quality attributes (2008)

Fermentation of Theobroma cacao (cacao) seeds is an absolute requirement for the full development of chocolate flavor precursors. An adequate aeration of the fermenting cacao seed mass is a fundamental prerequisite for a satisfactory fermentation. Here, we evaluated whether a controlled inoculation of cacao seed fermentation using a Kluyveromyces marxianus hybrid yeast strain, with an increased pectinolytic activity, would improve an earlier liquid drainage (‘sweatings’) from the fermentation mass, developing a superior final product quality. Inoculation with K. marxianus increased by one third the volume of drained liquid and affected the microorganism population structure during fermentation, which was detectable up to the end of the process. Introduction of the hybrid yeast affected the profile of total seed protein degradation evaluated by polyacrylamide gel electrophoresis, with improved seed protein degradation, and reduction of titrable acidity. Sensorial evaluation of the chocolate obtained from beans fermented with the K. marxianus inoculation was more accepted by analysts in comparison with the one from cocoa obtained through natural fermentation. The increase in mass aeration during the first 24 h seemed to be fundamental for the improvement of fermentation quality, demonstrating the potential application of this improved hybrid yeast strain with superior exogenous pectinolytic activity.
The Yeasts of Strawberries (1971)

SUMMARY: Nine hundred and fiftyseven strains of yeasts were isolated from fresh marketed strawberries over 2 seasons. There were c. 10 5 viable yeasts/g of strawberry: many more were isolated at 5° than at 25°. Most of the yeasts belonged to the genus Cryptococcus . Every yeast colony counted was subjected to identification tests selected by means of a computer‐made key, and identifications were done chiefly by semiquantitative aerobic growth tests combined with fermentation tests and microscopical examination of vegetative cells.
Induction of the Cellular MicroRNA, Hs_154, by West Nile Virus Contributes to Virus-Mediated Apoptosis through Repression of Antiapoptotic Factors (2012)

MicroRNAs (miRNAs) are a class of noncoding small RNAs that regulate multiple cellular processes, as well as the replication and pathogenesis of many DNA viruses and some RNA viruses. Examination of cellular miRNA profiles in West Nile virus (WNV)-infected HEK293 and SK-N-MC cells revealed increased expression of multiple miRNA species. One of these miRNAs, Hs_154, was significantly induced not only in WNV-infected neuronal cells in culture but also in the central nervous system tissues of infected mice and, upon transfection, caused a significant reduction in viral replication. Analysis of mRNA transcripts enriched through immunoprecipitation of the RNA-induced silencing complex identified several transcripts that contain seed sequence matches to Hs_154 in their 3' untranslated regions (UTRs). Two of these targets, the CCCTC-binding factor (CTCF) and the epidermal growth factor receptor (EGFR)-coamplified and overexpressed protein (ECOP/VOPP1) proteins display reduced expression in WNV-infected cells, and the 3' UTRs of these transcripts were sufficient to cause downregulation of expression in infected cells or in cells transfected with Hs_154, findings consistent with miRNA targeting of these transcripts. CTCF and ECOP have been shown to be associated with cell survival, implicating miRNA-directed repression of these targets in WNV-induced cell death. Consistent with this hypothesis, expression of these genes in WNV-infected cells results in a reduction in the number of cells undergoing apoptosis. These observations suggest that induction of Hs_154 expression after WNV infection modulates the apoptotic response to WNV and that cellular miRNA expression can be quickly altered during WNV infection to control aspects of the host response.
Protein trafficking in kinetoplastid protozoa. (1995)

The kinetoplastid protozoa infect hosts ranging from invertebrates to plants and mammals, causing diseases of medical and economic importance. They are the earliest-branching organisms in eucaryotic evolution to have either mitochondria or peroxisome-like microbodies. Investigation of their protein trafficking enables us to identify characteristics that have been conserved throughout eucaryotic evolution and also reveals how far variations, or alternative mechanisms, are possible. Protein trafficking in kinetoplastids is in many respects similar to that in higher eucaryotes, including mammals and yeasts. Differences in signal sequence specificities exist, however, for all subcellular locations so far examined in detail--microbodies, mitochondria, and endoplasmic reticulum--with signals being more degenerate, or shorter, than those of their higher eucaryotic counterparts. Some components of the normal array of trafficking mechanisms may be missing in most (if not all) kinetoplastids: examples are clathrin-coated vesicles, recycling receptors, and mannose 6-phosphate-mediated lysosomal targeting. Other aspects and structures are unique to the kinetoplastids or are as yet unexplained. Some of these peculiarities may eventually prove to be weak points that can be used as targets for chemotherapy; others may turn out to be much more widespread than currently suspected.
Approach and realization of a multi-tenant service composition engine (2013)

The support of multi-tenancy is an essential requirement to leverage the full extent of Cloud computing. Multi-tenancy enables service providers to maximize the utilization of their infrastructure and to reduce the servicing costs per customer. With regard to the fact that nowadays new applications or services are often composed out of multiple existing services or applications, a middleware is required which enables these compositions. A Service Composition Engine (SCE) provides the required functionality to enable the definition and execution of service compositions. In this diploma thesis we investigate the requirements and define an abstract architecture for the realization of a multi-tenant SCE. This architecture is prototypically realized with an open-source SCE and integrated into an existing multi-tenant aware ESB. The resulting middleware provides configurability for service compositions, tenant-aware messaging and tenant-based administration and management of the SCE and the ESB.
Timed-Release Polymer Nanoparticles (2013)

Triggered-release of encapsulated therapeutics from nanoparticles without remote or environmental triggers was demonstrated in this work. Disassembly of the polymer nanoparticles to unimers at precise times allowed the controlled release of oligo DNA. The polymers used in this study consisted of a hydrophilic block for stabilization and second thermoresponsive block for self-assembly and disassembly. At temperatures below the second block's LCST (i.e., below 37 °C for in vitro assays), the diblock copolymer was fully water-soluble, and when heated to 37 °C, the polymer self-assembled into a narrow size distribution of nanoparticles with an average diameter of approximately 25 nm. The thermoresponsive nature of the second block could be manipulated in situ by the self-catalyzed degradation of cationic 2-(dimethylamino)ethyl acrylate (DMAEA) units to negatively charged acrylic acid groups and when the amount of acid groups was sufficiently high to increase the LCST of the second block above 37 °C. The disassembly of the nanoparticles could be controlled from 10 to 70 h. The use of these nanoparticles as a combined therapy, in which one or more agents can be released in a predetermined way, has the potential to improve the personal point of care treatment of patients.
Phosphorylation of CD19 Y484 and Y515, and Linked Activation of Phosphatidylinositol 3-Kinase, Are Required for B Cell Antigen Receptor-Mediated Activation of Bruton’s Tyrosine Kinase (1999)

Bruton's tyrosine kinase (Btk) plays a critical role in B cell Ag receptor (BCR) signaling, as indicated by the X-linked immunodeficiency and X-linked agammaglobulinemia phenotypes of mice and men that express mutant forms of the kinase. Although Btk activity can be regulated by Src-family and Syk tyrosine kinases, and perhaps by phosphatidylinositol 3,4,5-trisphosphate, BCR-coupled signaling pathways leading to Btk activation are poorly understood. In view of previous findings that CD19 is involved in BCR-mediated phosphatidylinositol 3-kinase (PI3-K) activation, we assessed its role in Btk activation. Using a CD19 reconstituted myeloma model and CD19 gene-ablated animals we found that BCR-mediated Btk activation and phosphorylation are dependent on the expression of CD19, while BCR-mediated activation of Lyn and Syk is not. Wortmannin preincubation inhibited the BCR-mediated activation and phosphorylation of Btk. Btk activation was not rescued in the myeloma by expression of a CD19 mutant in which tyrosine residues previously shown to mediate CD19 interaction with PI3-K, Y484 and Y515, were changed to phenylalanine. Taken together, the data presented indicate that BCR aggregation-driven CD19 phosphorylation functions to promote Btk activation via recruitment and activation of PI3-K. Resultant phosphatidylinositol 3,4,5-trisphosphate probably functions to localize Btk for subsequent phosphorylation and activation by Src and Syk family kinases.
Analysis of saponins from black bean by electrospray ionization and fast atom bombardment tandem mass spectrometry (1999)

Saponins from black bean (Vigna mungo L. Hepper) were analyzed using positive and negative ion fast atom bombardment mass spectrometry (FAB-MS) and liquid chromatography/mass spectrometry. Methanol was used to extract the saponins from defatted black bean, which was partially purified by extraction with n-butanol, and the extract was dialyzed with 3000 M(r) cut-off tubing. The dialyzate was analyzed using mass spectrometry. According to FAB-MS/MS, mixtures from black bean contain soyasaponin I as the predominant saponin. In addition, MS/MS analysis was performed in which the structures of saponins of black bean cotyledon were determined to be soyasaponin I, soyasaponin II, soyasaponin V, 3-O-[alpha-L-rhamnopyranosyl-(1 --> 2)-beta-D-galactopyranosyl-(1 --> 2)-beta-D-glucuronopyranosyl]complogenin (saponin A) and 3-O-[alpha-L-rhamnopyranosyl-(1 --> 2)-beta-D-glucopyranosyl-(1 --> 2)-beta-D-glucopyranosyl]oleanolic acid (saponin B). For the black bean shell and the root of black bean sprout, analysis confirmed the saponins of soyasaponin I, soyasaponin II, soyasaponin V, saponin A, saponin B, acetylsoyasaponin A(4) and soyasaponin beta(g). Moreover, all the studied saponins were found in the stem and leaves of the black bean sprouts, except soyasaponin beta(g) and acetylsoyasaponin A(4), respectively.
Sports and Child Development (2016)

The role of curricular activities for the formation of education, health and behavioural outcomes has been widely studied. Yet, the role of extra-curricular activities has received little attention. This study analyzes the effect of participation in sports clubs-one of the most popular extra-curricular activities among children. We use alternative datasets and flexible semi-parametric estimation methods with a specific way to use the panel dimension of the data to address selection into sports. We find positive and robust effects on children's school performance and peer relations. Crowding out of passive leisure activities can partially explain the effects.
Plasmodium Falciparum in Culture: Establishment of Additional Strains (1978)

The establishment of new strains of Plasmodium falciparum in continuous culture is described. One line (FCR-2), isolated from an individual who had traveled extensively through South America, was passed initially through Aotus trivirgatus monkeys and then cultured into human erythrocytes using the flow-vial technique. A strain of P. falciparum FMG), shipped by air freight on wet ice from The Gambia, was cultured directly from a human infection into continuous culture using the Petri dish-candle jar technique, giving line FCR-3. Two other strains (6252 and FSG) were hand carried by a commercial flight on wet ice from the Gambia and were initiated into culture at the same time using the same media, sera, and erythrocytes. After 6 wk in vitro the 6252 strain became adapted as line FCR-4, whereas FSG had died out. Normal-looking gametocytes were seen in all four strains reported here. Notwithstanding their normal appearance they would not exflagellate in vitro, nor were they infective to Anopheles stephensi mosquitoes via membrane feeding. Production of new gametocytes continued for 6 mo, then gradually stopped.
Visual robot navigation using flat earth obstacle projection (2002)

Autonomous robot navigation requires the solution of several problems like obstacle avoidance and road following. Traditionally, the problem of obstacle avoidance has been solved by using range information acquired through some form of range measurements like laser range cameras or vision based range estimation. This paper presents a novel approach for obstacle avoidance which does not require true range measurement. Obstacle information is acquired using a single color camera. Detected obstacles are projected into 3D grid derived from the camera geometry and a locally flat earth model for the terrain. A weighted polar histogram technique is used to generate the vehicle steering angle based on the current grid information.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A General Strategy To Fabricate Ni<sub><i>x</i></sub>P as Highly Efficient Cocatalyst via Photoreduction Deposition for Hydrogen Evolution (2017)

Presently, precise deposition of transition metal phosphides at the electron outlet of photoactive materials as cocatalysts for hydrogen generation is rarely reported. Demonstrated here is a general photochemical strategy for the preparation of metal phosphides as cocatalysts for hydrogen generation. In this work, NixP was successfully deposited on g-C3N4 using nickel sulfate (NiSO4) and hypophosphite sodium (NaH2PO2) as Ni and P sources, respectively. The NixP/g-C3N4 composite exhibits excellent performance of hydrogen evolution via water splitting (about 8585 μmol g–1 h–1 in a triethanolamine aqueous solution under a 300 W Xe lamp with an AM 1.5G filter). More importantly, due to the intrinsic acid-resistant properties of NixP and g-C3N4, the NixP/g-C3N4 composite demonstrated excellent acid-stable photocatalytic activity for H2 evolution (stable run for 75 h under acidic solution of pH 2). Furthermore, the mechanism for photocatalytic activity of g-C3N4 enhanced by NixP was investigated in detail by steady-state photoluminescence spectra and surface photovoltage spectra, which indicated that separation efficiency of photogenerated carriers from g-C3N4 was effectively enhanced by NixP.
Optimising the SHA256 Hashing Algorithm for Faster and More Efficient Bitcoin Mining 1 (2013)

Since its inception in early 2009, Bitcoin has attracted a substantial amount of users and the popularity of this decentralised virtual currency is rapidly increasing day by day. Over the years, an arms race for mining hardware has resulted with miners requiring more and more hashing power in order to remain alive in the Bitcoin mining arena. The hashing rate and the energy consumption of the mining devices used are of utmost importance for the profit margin in Bitcoin mining. As Bitcoin mining is fundamentally all about computing the double SHA256 hash of a certain stream of inputs many times, a lot of research has been aimed towards hardware optimisations of the SHA256 Hash Standard implementations. However, no effort has been made in order to optimise the SHA256 algorithm specific to Bitcoin mining. This thesis covers the broad field of Bitcoin, Bitcoin mining and the SHA256 hashing algorithm. Rather than hardware based optimisations, the main focus of this thesis is targeted towards optimising the SHA256 hashing algorithm specific to the Bitcoin mining protocol so that mining can be performed faster and in a more efficient manner. These optimisations take advantage of the fixed or predictable nature of the input stream of data in Bitcoin mining and various shortcuts are discussed to calculate particular rounds or message schedules that achieve the same computational results as off-the-shelf SHA256. Although these algorithm based optimisations can no longer allow generic SHA256 hashing, they are meant to radically optimise the process of Bitcoin mining. It has been claimed that if these improvements are to be implemented in mining devices, the double SHA256 computation reduces to a 1.8624 SHA256 computation which essentially means a faster hashing rate and lots of energy savings.
Über Imidoylketenimine, III. Herstellung und Konformation von vinylogen Harnstoffen (1980)

Abstract Eine Anzahl neuer β‐Aminocrotonsäure‐ und ‐zimtsäureamide ( 3 ), meist mit 2‐Cyan‐, ‐Keto‐ oder ‐Estergruppen, wurde durch Addition von entsprechenden sekundären Enaminen 1 und Isocyanaten hergestellt. Im Fall von tert ‐Butylisocyanat bewährte sich hierbei die Katalyse mit Zinkchlorid. Einige Verbindungen 3 erhielt man aus β‐Ketocarbonamiden 2 mit sekundären Aminen. – Die Tautomerie von 2 und die Konformationen der in Lösung meist einheitlichen Verbindungen 3 wurden aus den Spektren abgeleitet (Typen A , B , C ).
High-amplitude noise detection by the expectation-maximization algorithm with application to swell-noise attenuation (2010)

Abstract High-amplitude noise is a common problem in seismic data. Current filtering techniques that target this problem first detect the location of the noise and then remove it by damping or interpolation. Detection is done conventionally by comparing individual data amplitudes in a certain domain to a user-controlled local threshold. In practice, the threshold is optimally tuned by trial and error and is often changed to match the varying noise power across the data set. We have developed an automatic method to compute the appropriate threshold for high-amplitude noise detection and attenuation. The main idea is to exploit differences in statistical properties between noise and signal amplitudes to construct a detection criterion. A model that consists of a mixtureof two statistical distributions, representing the signal and the noise, is fitted to the data. Then it is used to estimate the probability (i.e., likelihood) that each sample in the data is noisy by means of an expectation-maximization (EM) algorithm. Only those samples with a likelihood greater than a specific threshold are considered to be noise. The resulting probability threshold is better adapted to the data compared to a conventional amplitude threshold. It offers the user, through the probability threshold value, the possibility to quantify the confidence in whether a large amplitude anomaly is considered as noise. The method is generic; however, our work develops and implements the method for swell-noise attenuation. Initial results are encouraging, showing slightly better performance than an optimized conventional method but with much less parameter testing and variation.