gebhart/patrepeval huggingface dataset:
6-Phenyl-4,5-dihydro-3(2H)-pyridazinones. Series of hypotensive agents (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT6-Phenyl-4,5-dihydro-3(2H)-pyridazinones. Series of hypotensive agentsWilliam V. Curran and Adma RossCite this: J. Med. Chem. 1974, 17, 3, 273–281Publication Date (Print):March 1, 1974Publication History Published online1 May 2002Published inissue 1 March 1974https://pubs.acs.org/doi/10.1021/jm00249a004https://doi.org/10.1021/jm00249a004research-articleACS PublicationsRequest reuse permissionsArticle Views591Altmetric-Citations98LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Effect of Economic Indicators on Export Performance of India: Pre and post Liberalisation period (2012)

The paper examines the export growth affected by various economic indicators (GDP, IMPORTS, PERCAPITA NET NATIONAL INCOME, BALANCE OF PAYMENT, EXCHANGE RATE & INDUSTRIAL PRODUCTION), using data from 1986 to 2011. The paper studies the relationship between exports and indicators by using Karl Pearson’s coefficient of correlation and multiple correlation. t – Test helps to study the significance of relation. Diversification of India’s exports is depicted through the export import ratio. The paper concludes that the exports are mainly affected by three indicators (GDP, IMPORTS & PCCNI), and the change in policies should be made in accordance with them. Key Words: Export, GDP, Import, Pre and Post Liberalization Period.
An idea for electromagnetic "feedforward-feedbackward" media (1999)

An idea for a new class of complex media that we name feedforward-feedbackward (FFFB) media is presented and some of the results of our theoretical work in analyzing plane wave propagation in the axial direction through these media are described. The concept of FFFB media, as introduced here, was inspired by the theoretical research of Saadoun and Engheta (1992, 1994) on a variation of artificial chiral media. Like chiral media, to our knowledge there are no naturally occurring FFFB media for the microwave frequency band; for this reason we introduce an idea for artificial FFFB media. The focus of this paper is on one conceptualization of such media, namely dipole-dipole FFFB media. First, we present the calculation of the necessary constitutive parameters for studying axial plane wave propagation. Then we solve the macroscopic Maxwell equations in the k domain for axial plane wave propagation in an unbounded source-free crossed-dipole FFFB medium. Finally, we present the dispersion equation for this medium in this case, discuss some of the physical properties of its roots and certain features of the polarization eigenstates, and speculate some of the potential applications of this medium.
64Cu-ATSM internal radiotherapy to treat tumors with bevacizumab-induced vascular decrease and hypoxia in human colon carcinoma xenografts (2017)

Bevacizumab, an anti-vascular endothelial growth factor (VEGF) antibody, is an antiangiogenic agent clinically used for various cancers. However, repeated use of this agent leads to tumor-decreased vascularity and hypoxia with activation of an HIF-1 signaling pathway, which results in drug delivery deficiency and induction of malignant behaviors in tumors. Here, we developed a novel strategy to treat tumors with bevacizumab-induced vascular decrease and hypoxia using <sup>64</sup>Cu-diacetyl-bis (<i>N</i><sup>4</sup>-methylthiosemicarbazone) (<sup>64</sup>Cu-ATSM), a potential theranostic agent, which possesses high tissue permeability and can target over-reduced conditions under hypoxia in tumors, with a human colon carcinoma HT-29 tumor-bearing mouse model. The long-term treatment with bevacizumab caused decreased blood vessel density and activation of an HIF-1 signaling pathway; increased uptake of <sup>64</sup>Cu-ATSM was also observed despite limited blood vessel density in HT-29 tumors. <i>In vivo</i> high-resolution SPECT/PET/CT imaging confirmed reduced vascularity and increased proportion of <sup>64</sup>Cu-ATSM uptake areas within the bevacizumab-treated tumors. <sup>64</sup>Cu-ATSM therapy was effective to inhibit tumor growth and prolong survival of the bevacizumab-treated tumor-bearing mice without major adverse effects. In conclusion, <sup>64</sup>Cu-ATSM therapy effectively enhanced anti-tumor effects in tumors with bevacizumab-induced vascular decrease and hypoxia. <sup>64</sup>Cu-ATSM therapy could represent a novel approach as an add-on to antiangiogenic therapy.
PROXSEM: Interest-Based Proximity Measure to Improve Search Efficiency in P2P Systems (2007)

Peer-to-peer (P2P) file sharing systems are now at the origin of most of Internet traffic. Improving the performance of the query mechanism of such systems has generated a lot of interest both in industry and academia. In a P2P system, peers are connected to a subset of other peers with which they can communicate. Each peer maintains a cache and makes available its contents to the rest of the system. Connecting peers sharing similar interest in the context of a given application has recently been identified as a sound basis to improve the search efficiency. Nevertheless, capturing such interest-based (or semantic) proximity patterns is a difficult task. Most of current approaches measure this proximity between peers as the overlap between their cache contents. Given the well-known popularity patterns of peer-to-peer file sharing systems, the overlap between cache contents of two peers may not reflect accurately their semantic proximity. In this paper we propose PROXSEM, a refined proximity measure taking into account peer generosity and file popularity. We evaluated the proposed solution by simulation against a real peer-to-peer file sharing system (eDonkey) workload and results show the effectiveness of the proposed approach. While peers generosity can easily be computed locally, file popularity may require a global knowledge of the system. We also propose in this paper an epidemic algorithm to compute in a fully decentralised fashion an estimation of files popularity
Berlin (1989)

Die in Göttingen ausgelegte Saat war in jeder Beziehung stattlich herangewachsen und hatte so manches eingebracht. Die große Ernte erfolgte aber erst in Berlin. Dafür und für das Leben Walther Nernsts überhaupt ist das Jahr 1905 von außerordentlicher Bedeutung. Die Dichte wichtiger Ereignisse ist in ihm so groß, daß es sich lohnt, es gesondert zu betrachten.
Diagramming registration connectivity and structure [computer-assisted surgery] (1995)

Connectivity properties of registration graphs are useful in the study of registration pathways and immobilization requirements of computer-assisted surgery (CAS) systems. They can also be used as a diagrammatic technique for explaining CAS registration strategies and procedures. Several caveats should be observed: the relative technical difficulty of operations represented by the graphs is obscured; the graphs do not address the accuracy of individual measurement operations. At the level of detail shown here, the graphs do not distinguish measurement operations of full rank from those of reduced rank (fewer than six degrees of freedom). The authors know of at least one other way of forming an induced link, besides closing a simultaneous connected subgraph around it. This will be addressed in a subsequent report. Systems graphed here are represented to the best of the authors' knowledge and inference of their actual procedures. In some cases the authors have had to presume that, for instance, a measurement is established by a coordinate measuring machine, when it may in fact have been established some other way.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A high-availability high-performance e-mail cluster (2002)

Article A high-availability high-performance e-mail cluster Share on Author: Wyman Miles Rice University, Houston, TX Rice University, Houston, TXView Profile Authors Info & Claims SIGUCCS '02: Proceedings of the 30th annual ACM SIGUCCS conference on User servicesNovember 2002 Pages 84–88https://doi.org/10.1145/588646.588664Online:20 November 2002Publication History 3citation801DownloadsMetricsTotal Citations3Total Downloads801Last 12 Months6Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Vitronectin Expression and Interaction With Receptors in Smooth Muscle Cells From Human Atheromatous Plaque (1998)

Vitronectin (VN) is a plasma glycoprotein that promotes cell attachment and induces migration of human smooth muscle cells (SMCs) in culture. VN has been observed to accumulate in human atherosclerotic plaques, although its origin and role in atherosclerosis are not yet established. In the present experiments, synthesis of VN by intimal cells and its colocalization with receptors, alphavbeta3 and alphavbeta5, were studied by in situ hybridization and immunohistochemistry on 15 human atherosclerotic plaques from carotid arteries obtained after surgery. Strong VN protein and mRNA expression was observed in the intima and in the media. In the intima, VN mRNA expression was colocalized with SMCs, indicating that these cells produce VN, which may account for its accumulation in atherosclerotic plaques. In SMCs in culture, immunoprecipitation after metabolic labeling demonstrated that human SMCs do synthesize vitronectin. Confocal microscopic examination showed that VN colocalized with its receptors, alphavbeta3 and alphavbeta5, in the atherosclerotic intima. However, the distribution of the VN receptors on SMCs in culture in contact with VN was different. These observations suggest that VN plays various parts in atherogenesis via different SMC membrane receptors.
ConnectGPR 2014: the CoastCityCountry online network for an educational community of training for GP registrars gets bigger and better (2014)

Abstract of paper that presented at 2014 General Practice Education and Training Convention, 3-4 September, Brisbane, Queensland.
From product lines to self-managed systems (2005)

Adaptability and/or high availability are requirements which have become more prevalent and important for computing systems in recent years. To support adaptability and availability, a system must be able to dynamically change its behavior at runtime as user requirements, execution environments, or technologies change. Our aim is to develop a dynamic software product line in which a product line member can be dynamically modified after its deployment and thus new products can be produced during runtime without newly developing the products. To do so, we present a runtime reconfiguration framework based on reconfigurable components in supporting building dynamic product lines, particularly within the embedded software domain. Ultimately, our framework supports dynamic reconfiguration and not only reusable, but also reconfigurable components development in the context of self-managed systems.
Protocol boosters: applying programmability to network infrastructures (1998)

This article describes a novel methodology for protocol design, using incremental construction of the protocol from elements called protocol boosters on an as-needed basis. Protocol boosters are an adaptation technique that allows dynamic and efficient protocol customization to heterogeneous environments. By design, the boosting mechanism is under control of a policy, which determines when augmentation is required. Thus, many portions of a protocol stack execute only as necessary, permitting significant increases in performance relative to general-purpose protocols. Design principles for protocol boosters are presented, as well as an example booster. Two implementation platforms are described: (1) an augmented Linux operating system, which is freely available to other researchers; and (2) a rapidly reprogrammable hardware prototype, called the Programmable Protocol Processing Pipeline (P4), which is based on off-the-shelf FPGA technology. Since protocol boosters are programmed functions and can be network-resident, a programmable network infrastructure is necessary to exploit their full capability. Thus, protocol boosters are an ideal application for an on-the-fly programmable network infrastructure.
Post-communist Russia and anti-Americanism: has the West lost Russian public opinion? (2006)

Post-Communist Russia’s place in the international system has constituted a matter of intense academic interest since the end of the Cold War. In 2006, the relationship between the West and Russia cooled markedly in response to changing political alliances among the successor states of the former Soviet Union and Russia’s alleged use of its oil and gas resources for political purposes. Richard Pipes has warned that the West should not trust Russia because both its political elites and public opinion are hostile to Western values. This paper will argue that public opinion in Russia has been, and remains, mostly favourable towards the United States, Europe and the liberal democratic political system associated with the ‘West’ and that anti-Americanism, a discourse considered to be widespread in Europe, remains relatively weak in Russia. While many Russian politicians and ideologues have urged Russians to view the West as both foreign and hostile, a majority of the general public has steadfastly resisted. Sympathetic to Europe and unenthusiastic about new wars, Russia’s general public has proved a surprisingly resilient ally both for a pragmatic Russian foreign policy and for the West.
Non‐Bioengineered Silk Fibroin Protein 3D Scaffolds for Potential Biotechnological and Tissue Engineering Applications (2008)

This paper describes a new source for fabricating high-strength, non-bioengineered silk gland fibroin 3D scaffolds from Indian tropical tasar silkworm, Antheraea mylitta using SDS for dissolution. The scaffolds were fabricated by freeze drying at different prefreezing temperatures for pore size and porosity optimization. Superior mechanical properties with compressive strength in the range of 972 kPa were observed. The matrices were degraded by proteases within 28 d of incubation. Biocompatibility was assessed by feline fibroblast culture in vitro and confocal microscopy further confirmed adherence, spreading, and proliferation of primary dermal fibroblasts. Results indicate nonmulberry 3D silk gland fibroin protein as an inexpensive, high-strength, slow biodegradable, biocompatible, and alternative natural biomaterial. [Figure: see text].
Square wave jerks in parkinsonian syndromes. (1991)

The frequency of square wave jerks (SWJ) was compared in eight patients with progressive supranuclear palsy (PSP), 25 patients with multiple system atrophy or Parkinson's disease plus (MSA/PP), 85 patients with idiopathic Parkinson's disease (PD) and 20 age-matched normal volunteers. In the control group, the mean (SD) SWJ frequency (SWJ larger than 1 degree amplitude) was 2.3 (2.4)/min. Abnormal ocular fixation (SWJ frequency greater than 10/min) was observed in a large proportion of PSP patients (7/8) and of MSA/PP patients (16/25) but in few PD patients (13/85). In the group of PD patients with abnormal ocular fixation, freezing of gait, falls and instability were more severe than in the group of PD patients with normal fixation. The study of ocular fixation may help to differentiate PD clinically from other Parkinsonian syndromes. SWJ are probably not related to the central degeneration of the dopaminergic nigrostriatal pathway observed in PD.
Adhesion of corneal epithelial cells to cell adhesion peptide modified pHEMA surfaces (2001)

Epithelialization of a corneal implant is a desirable property. In this study we compared surface modification of poly (2-hydroxyethyl methacrylate) (pHEMA) with the cell adhesion peptides RGDS and YIGSR. Various parameters in the tresyl chloride activation and modification reactions were considered in order to maximize surface coverage with the peptide including tresyl chloride reaction solvent. tresyl chloride reaction time, tresyl chloride concentration, peptide concentration, and peptide reaction pH. Surface chemistry and corneal epithelial cell adhesion to the modified surfaces were examined. X-ray photoelectron spectroscopy data suggested that while peptide modification had occurred, surface coverage with the peptide was incomplete. Acetone was found to result in a higher fraction of nitrogen and surface bound carboxyl groups compared to dioxane and ether. Furthermore, corneal epithelial cell adhesion to the surfaces for which acetone was used for the activation reaction was significantly greater. Statistical analysis of the various samples suggests that lower peptide concentrations and higher tresyl chloride reaction times result in better cell adhesion. Furthermore, modification with YIGSR resulted in higher surface concentrations and better cell adhesion than modification with RGDS. Little or no cell adhesion was noted on the unmodified pHEMA controls. Protein adsorption results suggest that the differences in cell adhesion cannot be attributed to differences in serum protein adsorption from the culture medium. We conclude that YIGSR modified surfaces have significant potential for further development in corneal applications.
Efficient, broadly tunable, laser-pumped Tm:YAG and Tm:YSGG cw lasers (1990)

Broadly tunable cw laser emission is reported in Tm:YAG and Tm:YSGG at room temperature with Ti:sapphire laser pumping. The Tm(3+)(3)F(4) ? (3)H(6) transition is tuned continuously over the ranges 1.87-2.16 microm in YAG and 1.85-2.14 microm in YSGG. Smooth tuning results from overlapping transitions between phonon-broadened crystal field Stark levels.
EFFECT OF SEEDING RATE AND SUGAR CONCENTRATION ON YEAST GROWTH AND FERMENTATION IN AERATED GLUCOSE WORTS (1955)

The values of the fermentation coefficient (s), the growth coefficient (r) and the rate of total sugar usage (s + 0·476r) have been shown to vary with the yeast seeding rate, the sugar concentration and the conditions under which the seeding yeast is grown. The relationships between all these factors are discussed for yeast growth at 30° C. in glucose worts subjected to a standard degree of aeration.
Experience with a New Implantable Pacer‐, Cardioverter‐Defibrillator for the Therapy of Recurrent Sustained Ventricular Tachyarrhythmias: A Step Toward a Universal Ventricular Tachyarrhythmia Control Device (1991)

Ten consecutive patients (mean age 57.9 +/- 7.6 years) were treated with an investigational tachyarrhythmia control device, the implantable Medtronic Pacer-, Cardioverter-, Defibrillator model 7216A or 7217B. All patients had coronary artery disease with old myocardial infarctions and presented hemodynamically significant sustained ventricular tachyarrhythmias not suppressed by antiarrhythmic drug therapy and unrelated to acute myocardial infarction. In two patients a nonthoracotomy lead system was implanted. Lowest effective defibrillation energy ranged from 5 to 18 joules (mean 12.2 +/- 4 joules) for the epicardial bielectrode systems and were 15 and 18 joules for the nonthoracotomy lead system implants. The postoperative periods were unremarkable. Follow-up ranged from 7 to 19 months (mean 13.8 +/- 4.5 months). Spontaneous tachyarrhythmia episodes were detected and treated by the device in six patients, five of them received staged therapies. No deaths occurred and no hospital admissions were necessary for device related or ventricular tachyarrhythmia related complications. In conclusion, this integrated device represents a major step toward the development of a universal ventricular arrhythmia control device.
COMPLEMENTARY ENSEMBLE EMPIRICAL MODE DECOMPOSITION: A NOVEL NOISE ENHANCED DATA ANALYSIS METHOD (2010)

The phenomenon of mode-mixing caused by intermittence signals is an annoying problem in Empirical Mode Decomposition (EMD) method. The noise assisted method of Ensemble EMD (EEMD) has not only effectively resolved this problem but also generated a new one, which tolerates the residue noise in the signal reconstruction. Of course, the relative magnitude of the residue noise could be reduced with large enough ensemble, it would be too time consuming to implement. An improved algorithm of noise enhanced data analysis method is suggested in this paper. In this approach, the residue of added white noises can be extracted from the mixtures of data and white noises via pairs of complementary ensemble IMFs with positive and negative added white noises. Though this new approach yields IMF with the similar RMS noise as EEMD, it effectively eliminated residue noise in the IMFs. Numerical experiments were conducted to demonstrate the new approach and also illustrate the problems of mode splitting and translation.
High-efficiency near-infrared organic light-emitting devices based on an iridium complex with negligible efficiency roll-off (2013)

For NIR-emitting organic light-emitting devices (OLEDs), platinum complexes have the record maximum external quantum efficiency (EQE), although such devices generally suffer from severe efficiency roll-off with increasing current densities. Here, we report on iridium complexes as a competent alternative for NIR dyes with high EQEs and negligible efficiency roll-off. A simple, charge-neutral iridium complex, iridium(III) bis(2-methyl-3-phenylbenzo[g]quinoxaline-N,C′) acetylacetonate (Ir(mpbqx-g)2acac, 1), has been synthesized and characterized by a strong NIR emission with λmax,peak at 777 nm and λmax,shoulder at 850 nm in CH2Cl2 solutions. The single-crystal and electronic structure as well as photophysical and electrochemical properties were systematically studied in comparison with its cationic counterpart [Ir(mpbqx-g)2(Bphen)]+PF6− (2, Bphen = 4,7-diphenyl-1,10-phenanthroline). Complex 1 has seven times the quantum efficiency of complex 2 because of its much stronger spin–orbit coupling. NIR-emitting OLEDs based on complex 1 have been fabricated with a bipolar gallium complex as the host. The devices achieved a maximum EQE of up to 2.2% (J = 13 mA cm−2) and a maximum radiant emittance (Rmax) of 1.8 mW cm−2. In particular, the EQEs remained around 2% over a wide range of current densities from 3 to 100 mA cm−2.