gebhart/patrepeval huggingface dataset:
Current challenges for cancer vaccine adjuvant development (2018)

Poor immunogenicity of tumor antigens and tumor immune evasion mechanisms make the design of cancer vaccines challenging. Growing understanding of the tumor microenvironment and associated immune responses indicate the importance of augmenting not only the effector response, but also overcoming the endogenous regulatory response and tumor evasion mechanisms. Therefore, new vaccines will benefit from multi-adjuvanted approaches that simultaneously stimulate immunity while preventing inhibition.
Comparison of Tests for Detecting Leaks in the Low-Pressure System of Anesthesia Gas Machines (1997)

Small leaks in the low-pressure system (LPS) of the anesthesia gas machine can cause hypoxia or patient awareness. We sought to determine the relative sensitivities of the various tests recommended for detecting LPS leaks before anesthesia. Special adapters were fashioned to create leaks of six different sizes in the LPS that were equivalent to the following: a single 25-, 22-, 20-, or 15-gauge needle, two 15-gauge needles, or a 2.5-mm endotracheal tube connector. With each leak condition, five different leak tests were performed on three each of the following machines: Ohmeda Modulus I [TM], Ohmeda Modulus II [R]-Plus, and North American Drager Narkomed (2A, 3 and 4), for a total of 54 leaks to be detected for each leak test (3 x 3 x 6). The number of leaks detected with each test was compared by Fisher's exact test, P < 0.05 being considered significant. Only the negative pressure leak test detected all 54 leaks, a significant difference from the positive pressure test, which detected the least number of leaks, 28 (P < 0.05). Some leak tests are more suitable for specific anesthesia machines. Adoption of the negative pressure test as a universal LPS leak test may prevent the risks associated with using the wrong test for the particular anesthesia machine: hypoxic gas or patient awareness. (Anesth Analg 1997;84:179-84)
Antisense telomerase treatment: induction of two distinct pathways, apoptosis and differentiation (1998)

Telomerase, the enzyme that elongates telomeric DNA (TTAGGG)n, may be involved in cellular immortality and oncogenesis. To investigate the effect of inhibition of telomerase on tumor cells, we transfected the antisense vector against the human telomerase RNA into human malignant glioma cells exhibiting telomerase activity. After 30 doublings, some subpopulations of transfectants expressed a high level of interleukin-1beta-converting enzyme (ICE) protein and underwent apoptosis. In contrast, other subpopulations also showed enhanced ICE protein but escaped from apoptotic crisis and continued to grow, although their DNA synthesis, invasive ability, and tumorigenicity in nude mice were significantly reduced. Surviving cells demonstrated increased expression of glial fibrillary acidic protein and decreased motility, consistent with a more differentiated state. These cells also contained enhanced expression of the cyclin-dependent kinase inhibitors (CDKIs) p21 and p27. Treatment of surviving nonapoptotic cells with antisense oligonucleotides against p27, but not p21, induced apoptotic cell death, suggesting that p27 may have protected differentiating glioma cells from apoptosis. These data show that treatment with antisense telomerase inhibits telomerase activity and subsequently induces either apoptosis or differentiation. Regulation of these two distinct pathways may be dependent on the expression of ICE or CDKIs.
Digital wireless data acquisition system for measurement in high voltage substations (2006)

This paper describes a new digital wireless data acquisition system that can be used to measure electromagnetic interference (EMI) in power stations or other similar harsh environments. It comprises of a remote acquisition unit (RAU), a wireless data communication network (WDCN) and a PC-based control platform as a front end of the field-distributed-data-acquisition system, RAU captures, digitizes and stores the EMI signals in its memory and sends the information to the PC using the wireless data communication network. The WDCN acts as a bi-directional data communication link between the RAU & the control platform. It is based on Bluetooth technology and has a point-to-multipoint topology. The RAU serves as the acquisition function of a digital storage oscilloscope (DSO) while the control platform carries out the display & control function of a DSO. The whole system, as such, may be regarded as a `computerised wireless oscilloscope'. The system offers an innovative way for implementing monitoring, protection and testing systems based on wireless sensor networks
Parsing Indoor Scenes Using RGB-D Imagery (2012)

This paper presents an approach to parsing the Manhattan structure of an indoor scene from a single RGB-D frame. The problem of recovering the floor plan is recast as an optimal labeling problem which can be solved efficiently using Dynamic Programming.
The Hippo signaling pathway provides novel anti-cancer drug targets (2016)

The Hippo signaling pathway plays a crucial role in cell proliferation, apoptosis, differentiation, and development. Major effectors of the Hippo signaling pathway include the transcriptional co-activators Yes-associated protein 1 (YAP) and WW domain-containing transcription regulator protein 1 (TAZ). The transcriptional activities of YAP and TAZ are affected by interactions with proteins from many diverse signaling pathways as well as responses to the external environment. High YAP and TAZ activity has been observed in many cancer types, and functional dysregulation of Hippo signaling enhances the oncogenic properties of YAP and TAZ and promotes cancer development. Many biological elements, including mechanical strain on the cell, cell polarity/adhesion molecules, other signaling pathways (e.g., G-protein-coupled receptor, epidermal growth factor receptor, Wnt, Notch, and transforming growth factor β/bone morphogenic protein), and cellular metabolic status, can promote oncogenesis through synergistic association with components of the Hippo signaling pathway. Here, we review the signaling networks that interact with the Hippo signaling pathway and discuss the potential of using drugs that inhibit YAP and TAZ activity for cancer therapy.
The Chemotactic Action of Urokinase on Smooth Muscle Cells Is Dependent on Its Kringle Domain (2000)

Urokinase plasminogen activator (uPA) is thought to exert its effects on cell growth, adhesion, and migration by mechanisms involving proteolysis and interaction with its cell surface receptor (uPAR). The functional properties of uPA and the significance of its various domains for chemotactic activity were analyzed using human airway smooth muscle cells (hAWSMC). The wild-type uPA (r-uPAwt), inactive urokinase with single mutation (His(204) to Gln) (r-uPA(H/Q)), urokinase with mutation of His(204) to Gln together with a deletion of growth factor-like domain (r-uPA(H/Q)-GFD), the catalytic domain of urokinase (r-uPA(LMW)), and its kringle domain (r-KD) were expressed in Escherichia coli. We demonstrate that glycosylated uPA, r-uPAwt, r-uPA(H/Q), and r-uPA(H/Q)-GFD elicited similar chemotactic effects. Half-maximal chemotaxis (EC(50)) were apparent at approximately 2 nm with all the uPA variants. The kringle domain induced cell migration with an EC(50) of about 6 nm, whereas the denaturated r-KD and r-uPA(LMW) were without effect. R-uPAwt-induced chemotaxis was dependent on an association with uPAR and a uPA-kringle domain-binding site, determined using a monoclonal uPAR antibody to prevent the uPA-uPAR interaction, and a monoclonal antibody to the uPA-kringle domain. The binding of iodinated r-uPAwt with hAWSMC was due to interaction with a high affinity binding site on the uPAR, and a lower affinity binding site on an unidentified cell surface target, which was mediated exclusively through the kringle domain of urokinase. Specific binding of r-uPA(H/Q)-GFD to hAWSMC involved an interaction with a single site whose characteristics were similar to those of the low affinity site of r-uPAwt binding to hAWSMC. uPAR-deficient HEK 293 cells specifically bound r-uPAwt and r-uPA(H/Q)-GFD via a single, similar type of binding site. These cells migrated when stimulated by r-uPA(H/Q)-GFD and uPAwt, but not r-uPA(LMW). HEK 293 cells transfected with the uPAR cDNA expressed two classes of sites that bound r-uPAwt; however, only a single site was responsible for the binding of r-uPA(H/Q)-GFD. Together, these findings indicate that uPA-induced chemotaxis is dependent on the binding of the uPA-kringle to the membrane surface of cells and the association of uPA with uPAR.
Electrochemical in battery polymerization of poly(alkylenedioxythiophene) over lithium iron phosphate for high-performance cathodes (2014)

A molecular wiring concept was induced in LiFePO4 cathodes by in battery polymerization methods. This was performed by the addition of alkylthiophene monomers over the LiFePO4-based cathode during the first charging step in lithium test cells. The driving force for the in battery polymerization of the monomers was supplied by the oxidizing current and by the physical contact of monomers with delithiated Li1-xFePO4 formed during the charging of the battery. The resulting molecularly engineered cathodes give higher initial capacity, superior rate capability and improved cyclability compared to the pristine LiFePO4 compound. Further to observe changes in the oxidation state of iron, Mössbauer spectroscopy was employed and the results were correlated with those of impedance spectroscopy, which reveal a significant increase in conductivity during charging. The presented methods provide simple yet effective routes for manufacturing efficient cathode materials at room temperature, without the need of additional oxidizing compounds to carry out the polymerization process and to rival high temperature based carbon coatings.
The prevalence of pain complaints in a general population (1984)

The authors argue that the study of the complaint of pain falls within the purview of epidemiological study. An analytic survey of 500 randomly selected households on the roster of a group family practice clinic was undertaken. The purpose was to determine the self-reported prevalence rates of any pain complaint and to determine the distribution of pain rates according to selected demographic and socioeconomic variables. Sixteen percent of the individuals sampled from a family practice (H.S.O.) had experienced pain within the 2 weeks preceding the survey. The prevalence rate of those with persistent pain was approximately twice that of those with temporary pain. More women than men reported temporary and persistent pain. The age specific morbidity rate for persistent pain increased with age. The back, lower extremities, and head and face were the most frequently identified sites of pain in both subgroups. Persons with persistent pain used health services, both community physicians and hospital care, more frequently than did those with temporary pain. No significant differences between the two groups were reported for physical, social or emotional function although the persistent pain group characterized their general health status more poorly.
Global Control Plane Architecture for Cognitive Radio Networks (2007)

This paper presents an architecture for adaptive cognitive radio networks based on the concept of a "global control plane". The proposed control architecture uses a predetermined common coordination channel for spectrum etiquette, network establishment and adaptation to changing interference environments. The focus of this work is on design and evaluation of three key components of the control protocol - bootstrapping, discovery and naming/addressing. The bootstrapping protocol uses beacons to inform neighboring nodes about a node's PHY/MAC capabilities and current status. The network discovery protocol helps nodes to obtain a global view of reachability and end-to-end paths in the network by exchanging and propagating local link states. Further, nodes obtain their IP addresses and perform name to network address translations using a distributed naming/addressing scheme. An ns2 simulation model of the cognitive radio network with global control has been developed and used to evaluate performance in terms of network setup time, control overhead and achievable data throughput.
A parallel approach for high performance hardware design of intra prediction in H.264/AVC video codec (2009)

The H.264/AVC Intra Frame Codec (i.e. all frames are coded as I-frames) targets high-resolution/high-end encoding applications (e.g. digital cinema and high quality archiving etc.), providing much better compression efficiency at lower computational complexity compared to MJPEG2000. Moreover, in case of video coding of very high motion scenes, the number of Intra Macroblocks is dominant. Intra Prediction is a compute intensive and memory-critical part that consumes 80% of the computation time of the entire Intra Compression process when executing the H.264 encoder on MIPS processor [13]. We therefore present a novel hardware for H.264 Intra Prediction that processes all the prediction modes in parallel inside one integrated module (i.e. mode-level parallelism) enabling us to exploit the full space of optimization. It exhibits a group-based write-back scheme to reduce the memory transfers in order to facilitate the fast mode-decision schemes. Our Luma 4×4 hardware is 3.6×, 5.2×, and 5.5× faster than state-of-the-art approaches [13], QS0 [14], and [15], respectively. Our results show that processing Luma 16x16, Chroma 8×8, and Luma 4×4 with the proposed approach is 7.2×, 6.5×, and 1.8× faster (while giving an energy saving of 60%, 80%, and 74%) when compared with Dedicated Module Approach [13] (each prediction mode is processed with its independent hardware module i.e. a typical ASIC style for Intra Prediction). We get an area saving of 58% for Luma 4×4 hardware.
Time independence of the prognostic impact of tumor cell detection in the bone marrow of primary breast cancer patients. (2001)

TCD remains an independent prognostic factor The impact of TCD does not change with longer follow-up time. TCD is a reliable prognostic factor and provides important information about the process of metastasis.
Cromolyn inhibition of mediator release in mast cells derived from mouse bone marrow. (1986)

Mast cells derived from mouse bone marrow fail to demonstrate a disodium-cromoglycate-induced inhibition of mediator release when the cromolyn is added simultaneously with a secretagogue. To investigate the long-term effects of cromolyn exposure, cells from BALB/C femoral bone marrow stimulated with IL-3 were cultured in the presence of 1 to 100 microM cromolyn and demonstrated a similar viability and ability to proliferate as cells cultured in medium alone. Those cultured in cromolyn exhibited a significantly decreased A23187- or antigen-induced release of beta-hexosaminidase (4.3 +/- 0.7% versus 9.2 +/- 1.0%, p less than 0.01) compared with control cells. The adenosine-induced potentiation of mediator release was diminished to a comparable degree after cromolyn exposure in culture. This inhibition was dose-dependent between 1 and 100 microM cromolyn, evident by 5 days, reversible in 6 more days, and applied to immunoreactive leukotriene C4 generation as well. Bone marrow mast cells respond to chronic cromolyn exposure with a global inhibition of mediator release, but the basis for this response is unknown.
Vibration Control of a Cylindrical Shell Using Piezoelectric Actuators (1995)

This paper presents a method to control the vibration of a cylindrical shell system. The cylindrical shell system consists of a layer of plastic film and two layers of piezoelectric film, a part of which is used as the actuator. This study presents the analysis of vibration problem caused by periodic excitation. The problem is solved by means of the modal expansion method. A numerical simulation and an experiment of vibration control are performed by applying.<,(control theory to the cylindrical shell system. The result shows the effectiveness for the suppression of the forced vibration of the cylindrical shell system by using this control method.
SuperWeb: towards a global Web-based parallel computing infrastructure (2002)

The Internet, best known by most users as the World-Wide-Web, continues to expand at an amazing pace. We propose a new infrastructure to harness the combined resources, such as CPU cycles or disk storage, and make them available to everyone interested. This infrastructure has the potential for solving parallel supercomputing applications involving thousands of cooperating components. Our approach is based on recent advances in Internet connectivity and the implementation of safe distributed computing embodied in languages such as Java. We developed a prototype of a global computing infrastructure, called SuperWeb, that consists of hosts, brokers and clients. Hosts register a fraction of their computing resources (CPU time, memory, bandwidth, disk space) with resource brokers. Client computations are then mapped by the broker onto the registered resources. We examine an economic model for trading computing resources, and discuss several technical challenges associated with such a global computing environment.
On the Active Principles of the Euphorbiaceae (1983)

Three previously known ingenol esters, milliamines A-C and four new ingenol esters, milliamines D-G, all containing anthraniloyl tripeptides in various positions of ingenol, were isolated from roots and stems of Euphorbia milii, using a combination of counter-current distribution, preparative TLC and preparative HPLC. All the esters were fully characterised and showed irritant activity on the mouse ear. Neither milliamine A nor milliamine C (the most irritant ester) was a tumour promoter on mouse back skin.
Sensitive Detection of H<sub>2</sub>S Using Gold Nanoparticle Decorated Single-Walled Carbon Nanotubes (2009)

Herein, we demonstrate that highly sensitive conductometric gas nanosensors for H(2)S can be synthesized by electrodepositing gold nanoparticles on single-walled carbon nanotube (SWNT) networks. Adjusting the electrodeposition conditions allowed for tuning of the size and number of gold nanoparticles deposited. The best H(2)S sensing performance was obtained with discrete gold nanodeposits rather than continuous nanowires. The gas nanosensors could sense H(2)S in air at room temperature with a 3 ppb limit of detection. The sensors were reversible, and increasing the bias voltage reduced the sensor recovery time, probably by local Joule heating. The sensing mechanism is believed to be based on the modulation of the conduction path across the nanotubes emanating from the modulation of electron exchange between the gold and carbon nanotube defect sites when exposed to H(2)S.
Ductile superconducting Cu-rich alloys containing A-15 filaments (1975)

A new approach to a ductile composite of Cu and an A-15 superconducting compound has been reported recently. This new metallurgical process consists of melting the constituent elements and subsequent cold-working and heat treatment. The superconducting materials prepared by this technique are composed of about 90 atomic per cent Cu and a superconducting compound such as Nb <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> Sn or V <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> Ga which is in the form of fine filaments embedded in the Cu matrix. The new alloy is superconducting at a temperature nearly identical to that of the superconducting phase in bulk form. The current density (J <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</inf> ) is <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">\sim10^{4}</tex> to 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sup> A/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> at 4.2°K and zero magnetic field (J <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</inf> is calculated by taking the total cross-section of the specimen). An up-to-date account of the experimental situation in this field will be given. The discussion includes (1) the results of varying the alloy composition, the amount of cold-working and the heat treatment; (2) the transition temperature and J <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</inf> of Sn-coated Cu-(Nb <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> Sn) wires; (3) J <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</inf> as a function of transverse magnetic field; (4) the phenomenon of J <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</inf> enhancement as a result of mechanical deformation and (5) the basic mechanisms responsible for the observed superconductivity in these new materials.
Leishmania donovani-reactive Th1- and Th2-like T-cell clones from individuals who have recovered from visceral leishmaniasis (1993)

Infections in humans by Leishmania donovani parasites can result in a fatal disease, visceral leishmaniasis (VL), or in a self-limiting asymptomatic infection. In murine models of the infection employing Leishmania major, the course of the disease can be directed into a VL-like syndrome by interleukin-4 (IL-4)-producing Th2 cells, or cure may result by Th1 cells secreting gamma interferon (IFN-gamma). The present study examined the potential of human T cells to generate Th1 or Th2 responses to L. donovani. The profiles of IFN-gamma, IL-4, and lymphotoxin secretion after antigen stimulation were analyzed in a panel of L. donovani-reactive CD4+ human T-cell clones generated from individuals who had recovered from VL after antimonial treatment. Two of the T-cell clones produced large amounts of IL-4 without production of IFN-gamma, seven clones produced both IFN-gamma and IL-4, and eight produced only IFN-gamma. This is the first report of a Th1- and Th2-type response in human leishmaniasis. These results suggest that in analogy with murine models, there is a dichotomy in the human T-cell response to L. donovani infections. Preferential activation of IL-4-producing Th2-like cells may be involved in the exacerbation of human VL, whereas activation of IFN-gamma-producing Th1 cells may protect the host from severe disease. Identification of leishmanial antigens activating one or the other type of T cells will be important in the development of vaccines against leishmaniasis.
An indoor localization algorithm in a small-cell LED-based lighting system (2012)

Nowadays, the use of Visible Light Communications is growing towards several applications, due to the many benefits of this technology. By efficiently modulating visible light, it is possible to reach very high data rates, while at the same time providing illumination. As a result, traditional indoor systems, like open offices and homes, become smarter, providing high efficient services i.e., localization, positioning and navigation. In this paper, we propose a simple method for indoor localization service provided by infrared LED devices. The positioning estimation can be calculated by exploiting the uniform deployment of LED-based transmitters, and the information of the impulse responses. The comparison to the impulse responses time samples of a room map, opportunely built according to the transmitters' deployment, allows to estimate the position of a mobile device inside the room. The estimation error can be then reduced on the basis of the number of LED devices used.