gebhart/patrepeval huggingface dataset:
Well-Dispersed Chitosan/Graphene Oxide Nanocomposites (2010)

Nanocomposites of chitosan and graphene oxide are prepared by simple self-assembly of both components in aqueous media. It is observed that graphene oxide is dispersed on a molecular scale in the chitosan matrix and some interactions occur between chitosan matrix and graphene oxide sheets. These are responsible for efficient load transfer between the nanofiller graphene and chitosan matrix. Compared with the pure chitosan, the tensile strength, and Young's modulus of the graphene-based materials are significantly improved by about 122 and 64%, respectively, with incorporation of 1 wt % graphene oxide. At the same time, the elongation at the break point increases remarkably. The experimental results indicate that graphene oxide sheets prefer to disperse well within the nanocomposites.
Temperature dependence of emitter-base reverse stress degradation and its mechanism analyzed by MOS structures (2003)

Different degradation modes were observed under high and low reverse stress current conditions. The temperature dependence of the gradation was studied, and it was found that the degradation is greatest around 50 degrees C. The mechanisms of the degradation and its recovery were also investigated, using MOS structures and simulation. MOSFET evaluation indicated that electron trapping and interface state generation occur during the stress. Simulation confirmed that the degradation is caused mainly by the interface states generated in the oxide near the emitter-base junction.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Antitumoral activity of transferrin-lipoplexes carrying the IL-12 gene in the treatment of colon cancer (2006)

The present study aimed to establish an efficient targeted nonviral strategy for IL-12 gene transfer in colon carcinoma in vivo employing transferrin (Tf)-lipoplexes. Complexes for in vitro experiments were prepared at a 5/1(+/ - ) (lipid/DNA) charge ratio, with the ligand Tf (32 (microg/(microg DNA). Complexes for in vivo experiments contained 144 mM of total lipid (DOTAP/Chol), 60 (microg of pCMVLuc or pCMVIL-12 and 32 (microg of Tf-lipoplexes per microgram of plasmid. For intratumoral studies, CT26 (5 x 105 cells) in 50 microl of PBS were inoculated subcutaneously into the back of the mouse. Treatments began when tumor sizes reached 5-6 mm in diameter. Complexes were injected by a single intratumoral injection in a volume of 50 microl. Our in vitro results indicate that Tf-lipoplexes always mediate higher gene expression in colon (CT26) tumor cells, compared to plain-lipoplexes (without ligand) or naked plasmid. At the same time, CT26 tumor-bearing animals treated with Tf-lipoplexes containing the therapeutic gene IL-12, showed tumor growth inhibition, leading to a complete tumor regression in 75% of the treated mice (p < 0.001), without signs of recurrence. High levels of IL-12 and IFN-gamma were detected in the sera of treated mice. Mice survival also improved considerably by treatment with this system, with a survival rate of 88%, at 23 days post-administration. In summary, in this study we have developed an efficient, targeted cationic lipid-based system for the treatment of colon tumors. The vector has the advantages of ease of preparation and economy, in comparison with commercial transfection reagents, as well as, the possibility of a large scale production.
Acne treatment: a comparative efficacy trial of clindamycin and tetracycline. (1977)

Tetracycline was compared to clindamycin as adjunctive therapy in the treatment of moderate to moderately severe acne under double-blind controlled conditions. Both antibiotics were efficacious and differences were not appreciable. Lesion counts of both comedones and pustules were reduced and clinical improvement was noted in the majority of subjects. Side effects were not a problem. The place of clindamycin in the therapeutic armamentarium of the dermatologist is discussed.
A Novel Gate-Stack-Engineered Nanowire FET for Scaling to the Sub-10-nm Regime (2016)

In this paper, we propose a novel dual-metal gate-stack (DMSG) architecture with HfO2 spacer for scaling the nanowire FETs (NWFETs) to the sub-10-nm regime. We demonstrate that the electric field at the channel-drain extension interface is reduced when the inbuilt electric field arising due to a difference in the work function at the interface of the two metals in the DMSG is coupled to the nanowire through the fringing fields through the HfO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> spacer. The reduction in the electric field leads to a larger tunneling width, and therefore suppresses the lateral band-to-band-tunneling component of the gate-induced drain leakage in the DMSG NWFETs. Although the gate capacitance increases in the DMSG NWFETs due to the fringing fields, this paper demonstrates that the increase in the intrinsic delay (~1.5 times) is not very significant to degrade the circuit performance drastically. Using calibrated 3-D simulations, we show that the off-state current is reduced by more than five orders of magnitude in the DMSG NWFETs, leading to a significantly high on-state to off-state current ratio of ~10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sup> even when the channel length is scaled to 7 nm.
Rotational characteristics and stability of soft toric lenses. (1990)

Toric soft contact lenses of a double slab-off design were fitted to 72 patients (128 days) with varying refractive requirements. Rotational characteristics and lens stability were studied as related to sphere power, cylinder power, and axis orientation. The patients were followed over a 1-month period. Although rotation of all lenses was skewed nasally, the total number of all lenses showing no rotation or temporal was somewhat greater than those with nasal rotation. In addition lenses of oblique axis displayed the least amount of rotational instability. Finally this study suggests some differences when comparing the rotational characteristics between with-the-rule and against-the-rule astigmatism correction, low vs. high myopia, and myopia vs. hyperopia.
Optimization of the Dose Level for a Given Treatment Plan to Maximize the Complication-free Tumor Cure (1999)

During the past decade, tumor and normal tissue reactions after radiotherapy have been increasingly quantified in radiobiological terms. For this purpose, response models describing the dependence of tumor and normal tissue reactions on the irradiated volume, heterogeneity of the delivered dose distribution and cell sensitivity variations can be taken into account. The probability of achieving a good treatment outcome can be increased by using an objective function such as P+, the probability of complication-free tumor control. A new procedure is presented, which quantifies P+ from the dose delivery on 2D surfaces and 3D volumes and helps the user of any treatment planning system (TPS) to select the best beam orientations, the best beam modalities and the most suitable beam energies. The final step of selecting the prescribed dose level is made by a renormalization of the entire dose plan until the value of P+ is maximized. The index P+ makes use of clinically established dose-response parameters, for tumors and normal tissues of interest, in order to improve its clinical relevance. The results, using P+, are compared against the assessments of experienced medical physicists and radiation oncologists for two clinical cases. It is observed that when the absorbed dose level for a given treatment plan is increased, the treatment outcome first improves rapidly. As the dose approaches the tolerance of normal tissues the complication-free cure begins to drop. The optimal dose level is often just below this point and it depends on the geometry of each patient and target volume. Furthermore, a more conformal dose delivery to the target results in a higher control rate for the same complication level. This effect can be quantified by the increased value of the P+ parameter.
Laser action at 12.812 μm in optically pumped NH3 (1976)

Optical pumping of the aR (6,0) line of the ν2 fundamental vibrational band of NH3 has led to laser action on the aP (8,0) line at 12.812 μm of the same vibrational band. A 5-kW pulsed output has been obtained by using 1.5 MW of pump power at 9.294 μm from a CO2 laser.
AAS27, the Answer to an Engineer's Prayer (1993)

Reports of infrastructure failures and local studies of infrastructure asset replacement have indicated the need for modifications to accounting practices to show to the community the true cost of infrastructure assets and their consumption. Australian Accounting Standard No. 27 requires local governments to show as an expense the consumption of infrastructure assets in financial statements. In the past, engineers have not had an effective method of conveying the true cost of infrastructure assets to the community. AAS27 offers that opportunity. The paper outlines the engineering and accounting reasons behind AAS27 and argues that engineers must take a leading role in the introduction and implementation of AAS27 in their organisations.
Love & Work (2013)

Journal Article Love & Work Get access Miranda Field Miranda Field mirmot@aol.com Search for other works by this author on: Oxford Academic Google Scholar Literary Imagination, Volume 15, Issue 1, March 2013, Page 49, https://doi.org/10.1093/litimag/imt020 Published: 06 February 2013
Application of Process Tomography to Multiphase Flow Measurement in Industrial and Biomedical Fields: A Review (2017)

This paper reviews the latest development and emerging technologies on the application of process tomography to multiphase flow measurement in industrial and biomedical fields. In the industrial applications, electrical resistance tomography and electrical capacitance tomography are popularly applied in multiphase flow measurement dependent on the electrical properties of the objects. In particular, applications to circulating fluidized bed, trickle-bed reactor and temperature measurement are discussed. In the biomedical applications, in most cases, measurement is conducted in a static condition. Two latest applications in flowing condition are reviewed, which are thrombus detection in blood flow and cell sensing with a microfluidic device. Finally, the challenges to process tomography for multiphase flow measurement on industrial and biomedical applications are addressed.
Introduction (1999)

It is only comparatively recently in the history of civilisation that there has been widespread scepticism regarding religious experiences. Arguments against the plausibility of religious doctrines and reductionist accounts of religious experiences are now widely accepted, and many people lead atheistic lives which are to all appearances perfectly adequate. Therefore, religious individuals can no longer assume that experiences judged to be ‘genuine’ by fellow believers are immune from further attack. They are challenged on all sides, by philosophers, psychologists, sociologists, anthropologists, members of other religious traditions, and even by members of their own tradition with widely differing views. This book examines the value of religious experiences as evidence for religious claims. Its goal is to discover the role which religious experience can legitimately play in the defence of religious doctrines.
Evaluation of Internal Echo Histograms of Parotid Gland Tumors. (1993)

In order to obtain a cue for the differential diagnosis, we evaluated the internal echo histograms of 15 parotid gland tumors (12 benign, 3 malignant) with respect to standard deviation (SD) of the echo level and width of histograms at 0%, 25%, 50%, 75% frequency.1) The average SD of the echo level of malignant tumors was 8.43, which was significantly greater than that of benign tumors (p<0.05).2) An analysis of the width of the histograms showed three patterns: bell type for malignant tumors, mountain type with a wide base for benign tumors and mountain type with a narrow base for normal parotid glands.It is concluded that we can obtain objective information from the SD of the echo levels and the width of histograms for the differential diagnosis of parotid gland tumors.
Oligomerization and higher‐order assembly contribute to sub‐cellular localization of a bacterial scaffold (2013)

In Caulobacter crescentus, the PopZ polar scaffold protein supports asymmetric cell division by recruiting distinct sets of binding partners to opposite cell poles. To understand how polar organizing centres are established by PopZ, we investigated a set of mutated PopZ proteins for defects in sub-cellular localization and recruitment activity. We identified a domain within the C-terminal 76 amino acids that is necessary and sufficient for accumulation as a single subcellular focus, a domain within the N-terminal 23 amino acids that is necessary for bipolar targeting, and a linker domain between these localization determinants that tolerates large variation. Mutations that inhibited dynamic PopZ localization inhibited the recruitment of other factors to cell poles. Mutations in the C-terminal domain also blocked discrete steps in the assembly of higher-order structures. Biophysical analysis of purified wild type and assembly defective mutant proteins indicates that PopZ self-associates into an elongated trimer, which readily forms a dimer of trimers through lateral contact. The final six amino acids of PopZ are necessary for connecting the hexamers into filaments, and these structures are important for sub-cellular localization. Thus, PopZ undergoes multiple orders of self-assembly, and the formation of an interconnected superstructure is a key feature of polar organization in Caulobacter.
Therapeutic Targeting of Pancreatic Cancer via EphA2 Dimeric Agonistic Agents (2020)

Recently, we reported on potent EphA2 targeting compounds and demonstrated that dimeric versions of such agents can exhibit remarkably increased agonistic activity in cellular assays compared to the monomers. Here we further characterize the activity of dimeric compounds at the structural, biochemical, and cellular level. In particular, we propose a structural model for the mechanism of receptor activation by dimeric agents and characterize the effect of most potent compounds in inducing EphA2 activation and degradation in a pancreatic cancer cell line. These cellular studies indicate that the pro-migratory effects induced by the receptor can be reversed in EphA2 knockout cells, by treatment with either a dimeric natural ligand (ephrinA1-Fc), or by our synthetic agonistic dimers. Based on these data we conclude that the proposed agents hold great potential as possible therapeutics in combination with standard of care, where these could help suppressing a major driver for cell migration and tumor metastases. Finally, we also found that, similar to ephrinA1-Fc, dimeric agents cause a sustained internalization of the EphA2 receptor, hence, with proper derivatizations, these could also be used to deliver chemotherapy selectively to pancreatic tumors.
Iodination of Aromatic Amines with Iodine and Silver Sulfate (1992)

Abstract Iodination of aromatic amines with iodine / silver sulfate at room temperature gives iodo-products in good (46-96%) yield.
Separation of serotonin from catechols by capillary zone electrophoresis with electrochemical detection (1989)

Capillary zone electrophoresis with electrochemical detection is demonstrated with columns having only 9-microns inner diameter. Amperometric detection limits of 0.7 amol are reported for serotonin. The difficult problem of resolving serotonin and dopamine--two neurotransmitters of interest having similar electrophoretic mobilities--is addressed by chemical means to improve selectivity. These include buffer modification with 2-propanol and a system employing borate complexation of the catechol in combination with sodium dodecyl sulfate micelles.
Phase I and Pharmacokinetic Study of LY293111, an Orally Bioavailable LTB<sub>4</sub> Receptor Antagonist, in Patients With Advanced Solid Tumors (2005)

LY293111 can be administered safely by continuous oral therapy with mild toxicities. Diarrhea is dose-limiting. The recommended phase II dose will be 600 mg BID. The steady-state concentrations in humans exceed relevant levels observed in preclinical models.
Chemical reduction of graphene oxide: a synthetic chemistry viewpoint (2013)

The chemical reduction of graphene oxide is a promising route towards the large scale production of graphene for commercial applications. The current state-of-the-art in graphene oxide reduction, consisting of more than 50 types of reducing agent, will be reviewed from a synthetic chemistry point of view. Emphasis is placed on the techniques, reaction mechanisms and the quality of the produced graphene. The reducing agents are reviewed under two major categories: (i) those which function according to well-supported mechanisms and (ii) those which function according to proposed mechanisms based on knowledge of organic chemistry. This review will serve as a valuable platform to understand the efficiency of these reducing agents for the reduction of graphene oxide.
Isolation and properties of adenovirus type 2 proteinase. (1993)

We have cloned and expressed the human adenovirus type 2 proteinase gene in Escherichia coli. The expressed proteinase was isolated by a four-step chromatographic procedure. Purity and identity of the recombinant protein was established by two-dimensional gel electrophoresis, N-terminal sequencing, and specific antisera. The pure enzyme did not contain disulfide bridges, and it consisted of one subunit with a pI of 10.2. It did not show any sign of autocleavage. Labeled iodoacetate bound the pure enzyme while labeled diisopropyl fluorophosphate did not. The protease readily cleaved the viral pVII protein, ovalbumin, fibrin, and actin but had no effect on synthetic penta-, octa-, or nonapeptides carrying the consensus sequence for cleavage. The inhibitory profile of the isolated proteinase and the affinity labeling clearly indicate that the human adenovirus type 2 proteinase is a cysteine rather than a serine proteinase as previously believed. The most likely candidate for an active site residue is one of the two conserved cysteines, Cys-104 or Cys-122.
Sweet Potato Heritability Estimates and Their Use in Breeding (1986)

Abstract Awareness that the continuous variation of morphological traits in sweet potato can best be explained and studied with quantitative genetics has increased during the last 20 years (10, 16). This paper has 2 purposes: 1) to summarize available heritability estimates for traits of sweet potato and 2) to alert breeders to their use and application in crop improvement.
Extruders in Food Applications (2000)

Extruders in food applications / , Extruders in food applications / , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی
Is early laparoscopic cholecystectomy a safe procedure in patients when the duration of acute cholecystitis is more than three days? (2012)

Laparoscopic cholecystectomy is a safe and feasible procedure for patients with acute cholecystitis when the duration of symptoms is >3 days, however, a higher conversion rate is seen for acute chronic cholecystitis.
Electronic Structure of Bichalcophenes (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectronic Structure of BichalcophenesIgor Novak, Siu Choon Ng, Yek Tann Chua, Chup Yew Mok, and Hsing Hua HuangCite this: J. Phys. Chem. 1994, 98, 20, 5240–5243Publication Date (Print):May 1, 1994Publication History Published online1 May 2002Published inissue 1 May 1994https://pubs.acs.org/doi/10.1021/j100071a012https://doi.org/10.1021/j100071a012research-articleACS PublicationsRequest reuse permissionsArticle Views94Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Zum Stand der Extraktion mit komprimierten Gasen (1981)

Abstract Gase unter hohem Druck haben die Eigenschaften von Lösungsmitteln. Ihre Verwendung führt zu neuartigen Trennverfahren, die die Verfahrenstechnik der Stofftrennung um eine Gruppe neuer Verfahrensweisen erweitern. In der chemischen Reaktionstechnik können Katalysatoren in Gasphasen hoher Dichte gelöst und dadurch günstige Reaktionsbedingungen bewirkt werden. In der Nähe der kritischen Temperatur werden bei relativ mäßigen Drücken im Bereich von 50 bis etwa 300 bar bereits flüssigkeitsähnliche Dichten des komprimierten Gases erreicht. Es ergibt sich eine vergleichsweise hohe Lösefähigkeit der gasförmigen Phasen. Diese Eigenschaft eines komprimierten Gases kann durch Ändern von Druck und Temperatur in weiten Grenzen variiert werden. Mit abnehmender Dichte nähert es sich dem Verhalten eines normalen Gases, mit zunehmender Dichte dem einer Flüssigkeit. Somit ergibt sich die Möglichkeit, die gelösten Stoffe wieder auszufällen. Durch die kritische Temperatur des verwendeten Gases ist die Arbeitstemperatur eines solchen Verfahrens weitgehend festgelegt. Da eine Reihe leicht verfügbarer Gase kritische Temperaturen im Bereich bis 50°C besitzen, wurde bei Entwicklung dieser Verfahren zunächst die Trennung temperaturempfindlicher und schwerflüchtiger Stoffmischungen behandelt. Darüber hinaus versprechen polare Stoffe mit erheblich höher liegenden kritischen Temperaturen wie Ammoniak, Methanol und Wasser eine Reihe weiterer Anwendungsmöglichkeiten.
Spiral microchannel with rectangular and trapezoidal cross-sections for size based particle separation (2013)

The paper reports a new method for three-dimensional observation of the location of focused particle streams along both the depth and width of the channel cross-section in spiral inertial microfluidic systems. The results confirm that particles are focused near the top and bottom walls of the microchannel cross-section, revealing clear insights on the focusing and separation mechanism. Based on this detailed understanding of the force balance, we introduce a novel spiral microchannel with a trapezoidal cross-section that generates stronger Dean vortices at the outer half of the channel. Experiments show that particles focusing in such device are sensitive to particle size and flow rate, and exhibits a sharp transition from the inner half to the outer half equilibrium positions at a size-dependent critical flow rate. As particle equilibration positions are well segregated based on different focusing mechanisms, a higher separation resolution is achieved over conventional spiral microchannels with rectangular cross-section.