gebhart/patrepeval huggingface dataset:
Towards demonstrating multi-scale free-space optical interconnects for intrachip global communications (2004)

The impending saturation of Moore’s Law, due to the lack of bandwidth capacity of global metal wires, might be delayed with optical interconnects in a multi-scale architecture combining micro-optical lenses and prisms with a macro-optical curved mirror. Steps taken toward demonstrating multi-scale optical interconnects for intrachip global communications are discussed.
Suppressive effect of saprogrelate hydrochloride on Raynaud’s phenomenon and respiratory failure in patients with systemic sclerosis (2000)

SH therapy could prevent RP and respiratory failure in patients with SS.
[Pre-operative chemotherapy in non-small cell lung cancer]. (2005)

Pre-operative chemotherapy for non-small cell bronchial carcinoma (NSCLC) has the twin objectives of destruction of micrometastases and increased resectabilty of the primary tumour. The trials of Rosell and Roth showed weak benefits in favour of the combination. In the French trial overall survival was no different for the whole group but was improved in early stage disease. Preliminary results of the SWOG trial show a non-significant difference in 2 year survival of 6%. The EORTC 08941 trial showed no difference between surgery and radiotherapy following induction chemotherapy in non-resectable stage IIIAN2 NSCLC. The INT-0139 trial compared surgery following induction chemo-radiotherapy with chemo-radiotherapy alone. There was no difference between the two strategies but analysis of sub-groups suggested that some groups might benefit from the triple combination. Two further trials await publication. The small number of patients in each trial suggests that a meta-analysis will be necessary to reach a definite conclusion. The combination of surgery and chemotherapy is becoming standard in stage II disease. Only the timing, pre- or post-operative, remains controversial. At present, of the original objectives, only the destruction of micro-metastases has been confirmed.
Novel murine B‐cell lymphoma/leukemia model to study BCL2‐driven oncogenesis (2005)

The BCL-2 family has been implicated in the pathogenesis of various hematopoietic malignancies, including follicular non-Hodgkin lymphoma and B-cell chronic lymphocytic leukemia. To identify genes that act synergistically in BCL2-enforced leukemogenesis, we developed a murine B-cell lymphoma/leukemia model based on the IL-3-dependent Balb/C pro-B line (FL5.12). FL5.12 cells were stably transfected with antiapoptotic BCL-2 alone or in combination with proapoptotic BAX or nonfunctional mutant BAX, thereby creating various levels of imbalance within the BCL-2 family. Transfectants were intravenously injected into normal Balb/C mice. Whereas FL5.12 cells did not provoke leukemia, mice injected with stable transfectants died of leukemia over time. Disease incidence and latency time depended on the degree of imbalance in the BCL-2 family, supporting a model whereby BCL2 drives tumorigenesis. All mice presented with hepatosplenomegaly and leukemic FL5.12 cells in peripheral blood and bone marrow compartments. Leukemic conversion was accompanied by secondary genetic aberrations leading to clonal IL-3-responsive leukemia. Cellular transformation was independent of alterations in c-Myc or downstream apoptotic pathway. Leukemic clones retained a normal DNA damage response leading to elevated P53 and P21 levels and cell cycle arrest upon irradiation. In conclusion, our mouse model may prove a valuable tool to identify genes that cooperate in BCL2-enforced lymphoma/leukemogenesis.
ChemInform Abstract: Large Scale Asymmetric Synthesis of a Biologically Active Sulfoxide. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
β1-Integrin and PTEN control the phosphorylation of protein kinase C (2000)

Phosphorylation of protein kinase C (PKC) provides an amplitude control that operates in conjunction with allosteric effectors. Under many conditions, PKC isotypes appear to be highly phosphorylated; however, the cellular inputs that maintain these phosphorylations are not characterized. In the present work, it is shown that there is a differential phosphorylation of PKCdelta in adherent versus suspension cultures of transfected HEK-293 cells. It is established that integrin activation is sufficient to trigger PKCdelta phosphorylation and that this signals through phosphoinositide 3-kinase (PI3-kinase) to stimulate the phosphorylation of two sites, T505 and S662. The loss of signal input to PKCdelta in suspension culture is dependent on the tumour suppressor gene PTEN, which encodes a bi-functional phosphotyrosine/phosphoinositide 3-phosphate phosphatase. In the PTEN(-/-) UM-UC-3 bladder carcinoma cell line grown in suspension, transfected PKCdelta no longer accumulates in a dephospho-form on serum removal. By contrast, in a UM-UC-3-derivative cell line stably expressing PTEN, PKCdelta does become dephosphorylated under these conditions. Employing the PTEN Gly(129)-->Glu mutant, which is selectively defective in lipid phosphatase activity, it was established that it is the lipid phosphatase activity that controls PKCdelta phosphorylation. The evidence indicates that PKCdelta phosphorylation and its latent activity are maintained in serum-deprived adherent cultures through integrin-matrix interactions. This control acts through a pathway involving a lipid product of PI3-kinase in a manner that can be suppressed by PTEN.
Evaluation of laminar flow control systems concepts for subsonic commercial transport aircraft (1983)

An evaluation was made of laminar flow control (LFC) system concepts for subsonic commercial transport aircraft. Configuration design studies, performance analyses, fabrication development, structural testing, wind tunnel testing, and contamination-avoidance techniques were included. As a result of trade studies, a configuration with LFC on the upper wing surface only, utilizing an electron beam-perforated suction surface, and employing a retractable high-lift shield for contamination avoidance, was selected as the most practical LFC system. The LFC aircraft was then compared with an advanced turbulent aircraft designed for the same mission. This comparison indicated significant fuel savings and reduced direct operating cost benefits would result from using LFC.
Melatonin as a free radical scavenger in the ovarian follicle [Review] (2012)

This review summarizes new findings related to beneficial effects of melatonin (N-acetyl-5-methoxytryptamine) on reproductive physiology. Recently many researchers have begun to study the local role of melatonin as an antioxidant. We focused on intra-follicular role of melatonin in the ovary. Melatonin, secreted by the pineal gland, is taken up into the follicular fluid from the blood. Reactive oxygen species (ROS) are produced within the follicles, during the ovulatory process. Melatonin reduces oxidative stress as an antioxidant, and contribute to oocyte maturation, embryo development and luteinization of granulosa cells. Our clinical study demonstrated that melatonin treatment for infertile women increases intra-follicular melatonin concentrations, reduces intra-follicular oxidative damage, and elevates fertilization and pregnancy rates. Melatonin treatment also improves progesterone production by corpus luteum in infertile women with luteal phase defect. Melatonin treatment could become a new cure for improving oocyte quality and luteal function in infertile women.
Inverting for Slip on Three-Dimensional Fault Surfaces Using Angular Dislocations (2005)

The increasing quality of geodetic data (synthetic aperture radar interferometry [insar] dense Global Positioning System [gps] arrays) now available to geophysicists and geologists are not fully exploited in slip-inversion procedures. Most common methods of inversion use rectangular dislocation segments to model fault ruptures and therefore oversimplify fault geometries. These geometric simplifications can lead to inconsistencies when inverting for slip on earthquake faults, and they preclude a more complete understanding of the role of fault geometry in the earthquake process. We have developed a new three-dimensional slip-inversion method based on the analytical solution for an angular dislocation in a linear-elastic, homogeneous, isotropic, half-space. The approach uses the boundary element code Poly3D that employs a set of planar triangular elements of constant displacement discontinuity to model fault surfaces. The use of triangulated surfaces as discontinuities permits one to construct fault models that better approximate curved three-dimensional surfaces bounded by curved tiplines: shapes that commonly are imaged by three-dimensional reflection seismic data and inferred from relocated aftershock data. We demonstrate the method’s ability to model three-dimensional rupture geometries by inverting for slip associated with the 1999 Hector Mine earthquake. The resulting model avoids displacement anomalies associated with the overlapping rectangular dislocations used in previous models, improving the fit to the geodetic data by 32%, and honors the observed surface ruptures, thereby allowing more direct comparisons between geologic and geodetic data on slip distributions. Online Material : Hector Mine input files and file format description.
Semantics for the Semantic Web (2011)

Enabling applications that exploit heterogeneous data in the Semantic Web will require us to harness a broad variety of semantics. Considering the role of semantics in a number of research areas in computer science, we organize semantics in three forms — implicit, formal, and powerful — and explore their roles in enabling some of the key capabilities related to the Semantic Web. The central message of this article is that building the Semantic Web purely on description logics will artificially limit its potential, and that we will need to both exploit well-known techniques that support implicit semantics, and develop more powerful semantic techniques.
Surface‐Triggered Tandem Coupling Reactions of Cyclic Azasilanes (2017)

Cyclic azasilanes have been synthesized for the purpose of developing coupling agents appropriate for a variety of nanotechnologies including surface modification of nanoparticles, nanocrystals, mesoporous materials and substrates. N-Methyl-aza-2,2,4-trimethylsilacyclopentane is representative of this class of compounds. Preliminary data for the treatment of inorganic surfaces, including nanoparticles and oxidized silicon wafers, with cyclic azasilanes suggest high-density monolayer deposition by a ring-opening reaction. Cyclic azasilanes contain a cryptic amine functionality that can perform a subsequent tandem coupling reaction with functional molecules after the surface-triggered ring-opening reaction, allowing for a one-pot self-assembly route on nanostructures. Tandem coupling reactions are demonstrated via addition reactions of the cryptic amine with epoxy and acrylate systems.
New Pseudopterosin and <i>s</i><i>eco</i>-Pseudopterosin Diterpene Glycosides from Two Colombian Isolates of <i>Pseudopterogorgia </i><i>e</i><i>lisabethae</i> and Their Diverse Biological Activities (2004)

As part of an ongoing program to explore the chemical constituents of Caribbean marine invertebrates, a family of 13 new diterpene glycosides, pseudopterosins P-Z (1-11) and seco-pseudopterosins H (12) and I (13), have been isolated from the organic extracts of two collections of the sea whip Pseudopterogorgia elisabethae procured near the Colombian Southwestern Caribbean Sea. The structures of compounds 1-13, including absolute stereochemistry, have been proposed on the basis of comprehensive spectral analyses, chemical transformations, specific rotation, and TLC chromatographic analyses. Pseudopterosin Q (2) inhibited thromboxane B2 (TXB2) (IC50 = 4.7 microM) and superoxide anion (O2-) (IC50 = 11.2 microM) generation from E. coli lipopolysaccharide (LPS) activated rat neonatal microglia in vitro. In contrast, pseudopterosins P (1), U (6), V (7), W (8), and X (9) as well as seco-pseudopterosins H (12) and I (13) demonstrated minimal effects on both TXB2 and O2- release. In addition, some of the new compounds displayed strong antituberculosis, antiviral, antimalarial, and anticancer activity.
Design Strategies for High‐Performance Aqueous Zn/Organic Batteries (2020)

Organic electroactive compounds are attractive to serve as the cathode materials of aqueous zinc-ion batteries (ZIBs) because of their resource renewability, environmentally friendliness and structural diversity. Up to now, various organic electrode materials have been developed and different redox mechanisms are observed in aqueous Zn/organic battery systems. In this Minireview, we present the recent developments in the energy storage mechanisms and design of the organic electrode materials of aqueous ZIBs, including carbonyl compounds, imine compounds, conductive polymers, nitronyl nitroxides, organosulfur polymers and triphenylamine derivatives. Furthermore, we highlight the design strategies to improve their electrochemical performance in the aspects of specific capacity, output voltage, cycle life and rate capability. Finally, we discuss the challenges and future perspectives of aqueous Zn/organic batteries.
<i>Salmonella</i>vaccines in poultry: past, present and future (2012)

Salmonella species are important zoonotic pathogens that cause gastrointestinal disease in humans and animals. Poultry products contaminated with these pathogens are one of the major sources of human Salmonella infections. Vaccination of chickens, along with other intervention measures, is an important strategy that is currently being used to reduce the levels of Salmonella in poultry flocks, which will ultimately lead to lower rates of human Salmonella infections. However, despite numerous studies that have been performed, there is still a need for safer, well-defined Salmonella vaccines. This review examines the different classes of Salmonella vaccines that have been tested, highlighting the merits and problems of each, and provides an insight into the future of Salmonella vaccines and the platforms that can be used for delivery.
Automatic verification of any number of concurrent, communicating processes (2002)

The automatic verification of concurrent systems by model-checking is limited due to the inability to generalise results to systems consisting of any number of processes. We use abstraction to prove general results, by model-checking, about feature interaction analysis of a telecommunications service involving any number of processes. The key idea is to model-check a system of constant number (m) of concurrent processes, in parallel with an "abstract" process which represents the product of any number of other processes. The system, for any specified set of selected features, is generated automatically using Perl scripts.
Into the Moana<sup>1</sup> &#x2014; Hypergraph-based network layer indirection (2013)

In this paper, we introduce the Moana network infrastructure. It draws on well-adopted practices from the database and software engineering communities to provide a robust and expressive information-sharing service using hypergraph-based network indirection. Our proposal is twofold. First, we argue for the need for additional layers of indirection used in modern information systems to bring the network layer abstraction closer to the developer's world, allowing for expressiveness and flexibility in the creation of future services. Second, we present a modular and extensible design of the network fabric to support incremental architectural evolution and innovation, as well as its initial evaluation.
Generate an Encryption Key by using Biometric Cryptosystems to secure transferring of Data over a Network (2013)

The chief problem is to protect our data in a unique way that could only be worked upon by the sender and the recipient. Most of the traditional techniques probably in-use today, emphasizes on keys that are generated by generic function, algorithms or in random key generators. But question remains whether this key is unique and authentic in nature. Moreover how can these keys be unique to one and one person only? The answer to this would be Biometric Cryptosystems. Biometric Cryptosystems are the newest members in the field of security. The very basis of this Biometric Cryptosystem lies on the very fact that some features of human body are significantly unique to each and every human in the world, such as fingerprint, DNA sequence, Iris, etc. Using those biometric we can generate an exclusive key that will be unique for each and every individual. Now having generated these keys we can use them for encrypting our message. And as because these keys are uniquely generated for individual persons there's no chance of there will be a matching keys. Moreover as we use RSA algorithm based encryption technique so the encryption lies on two basic sets of keys to decrypt the message. Hence, eavesdropper or third unwanted parties have to acquire two set of keys which adds up to security level of the encryption and hence protect the message from unwanted third parties from acquiring our secret message.
A Feasibility Study on the Simultaneous Sensing of Turbidity and Chlorophyll a Concentration Using a Simple Optical Measurement Method (2017)

We have been developing a wireless sensor network system to monitor the quality of lake water in real time. It consists of a sensor module and a system module, which includes communication and power modules. We have focused on pH, turbidity and chlorophyll a concentration as the criteria for qualifying lake water quality. These parameters will be detected by a microfluidic device based sensor module embedded in the wireless sensor network system. In order to detect the turbidity and the chlorophyll a concentration simultaneously, we propose a simple optical measurement method using LED and photodiode in this paper. Before integrating a turbidity and chlorophyll a concentration sensor into the microfluidic device based pH sensor, we performed feasibility studies such as confirmation of the working principle and experiments using environmental water samples. As a result, we successfully verified our simultaneous sensing method by using a simple optical setup of the turbidity and the chlorophyll a concentration.
Thermally activated shape memory behavior of melt‐mixed polyurethane/cellulose nanocrystal composites (2017)

ABSTRACT Building blocks made from renewable sources attract increasing attention for the design of new polymer systems. Recently, in this particular context, cellulose nanocrystals (CNCs) have gained great interest in both academic research and industry, mainly on account of their ability to reinforce range of polymer matrices and afford nanocomposites with attractive mechanical properties. The limited thermal stability of conventionally produced cellulose nanocrystals (CNCs) has, however, so far limited the range of polymers that could be used as basis for melt‐processed CNC nanocomposites. We herein show that a commercially accessible nanocrystal source, a particular grade of microcrystalline cellulose (MCC), can easily be converted into thermally stable CNCs by ultrasonication in phosphoric acid. A scalable melt‐mixing process was used to produce nanocomposites of these CNCs with a thermoplastic polyurethane (TPU) elastomer. A significant improvement of the room temperature storage modulus from 40 MPa (neat polymer) to 120 MPa (10% w/w CNC) was observed. The introduction of CNCs not only increased the stiffness of the polymer matrix, but also improved the shape memory properties of the nanocomposite. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017 , 134 , 45033.
La percepciôn de los estudiantes sobre su evaluación en la universidad. Un estudio en la facultad de ciencias de la educación (1999)

Se incluye como anexo el Cuestionario acerca de las Percepciones de los Estudiantes sobre su Evaluacion en la Universidad
Measurement of augmentation of <sup>252</sup>Cf implant by <sup>10</sup>B and <sup>157</sup>Gd neutron capture (1994)

252Cf has been used as a brachytherapy source since the early 1970s. The dominant mechanism of interactions of 252Cf neutrons with tissue is elastic scattering. The scattered neutrons lose part of their energy, which is released as kinetic energy of the recoiling nuclei. By multiple scattering, neutrons lose their energy and eventually become thermalized (in energetic equilibrium with tissue atoms with an average energy of 0.025 eV) and do not play any role in radiotherapy. These thermal neutrons may interact with hydrogen nuclei or with nitrogen, but the cell killing effects by these reaction products are negligibly small compared to the elastic scattering by fast neutrons or by photons emitted by californium. Nonetheless, these thermal neutrons are still potentially usable for neutron capture therapy and can be used to enhance californium brachytherapy effects. Neutron capture therapy is a two-part therapy relying on the selective loading of tumor cells with compounds containing 10B or 157Gd and subsequent irradiation with thermal neutrons. To calculate neutron capture doses one has to know thermal neutron flux. This paper presents results of an experimental study of thermal neutron flux and calculations of boron neutron capture and gadolinium neutron capture doses in the vicinity of 252Cf sources.
Long range order in AlxGa1−xN films grown by molecular beam epitaxy (1997)

The first observation of atomic long range ordering in AlxGa1−xN thin films grown by electron cyclotron resonance assisted molecular beam epitaxy on sapphire and 6H-SiC substrates is reported. The phenomenon was investigated by studying the superlattice peaks (0001), (0003), and (0005) using x-ray diffraction. The relative intensity of these peaks was found to be largest for Al content in the 30%–50% range in qualitative agreement with expectations for an ordered structure of ideal Al0.5Ga0.5N stoichiometry. The average size of the ordered domains in the films was found to be within a factor of 4 of the films’ thicknesses. The degree of ordering depends on the III/V flux ratio and exhibits a weaker dependence on Si doping.