gebhart/patrepeval huggingface dataset:
Intelligent Experimental Design Using an Artificial Neural Network Meta Model and Information Theory (2006)

Ability to rapidly design products and their manufacturing process is a key to being competitive in a dynamic market environment. Traditional methods of design of experiment development are unsatisfactory when applied to design problems with large number of input variables and nonlinear input-output relation. A meta-model driven experimental design scheme is developed. The approach uses artificial neural network as the meta-model, and a combination of random-search, fuzzy classification, and information theory as the design tool. An information free energy index is developed which balances the needs for resolving the uncertainty of the model and the relevance to finding the optimal design. The procedure involves iterative steps of meta-model construction, designing new experiments using meta-model and actual execution of designed experiments. The effectiveness of this approach is benchmarked using a simple optimization problem. Three industrial examples are presented to illustrate its applicability to a variety of design problem.
Privado: Practical and Secure DNN Inference. (2018)

Recently, cloud providers have extended support for trusted hardware primitives such as Intel SGX. Simultaneously, the field of deep learning is seeing enormous innovation and increase in adoption. In this paper, we therefore ask the question: Can third-party cloud services use SGX to provide practical, yet secure DNN Inference-as-a-service? Our work addresses the three main challenges that SGX-based DNN inferencing faces, namely, security, ease-of-use, and performance. 
We first demonstrate that side-channel based attacks on DNN models are indeed possible. We show that, by observing access patterns, we can recover inputs to the DNN model. This motivates the need for Privado, a system we have designed for secure inference-as-a-service. Privado is input-oblivious: it transforms any deep learning framework written in C/C++ to be free of input-dependent access patterns. Privado is fully-automated and has a low TCB: with zero developer effort, given an ONNX description, it generates compact C code for the model which can run within SGX-enclaves. Privado has low performance overhead: we have used Privado with Torch, and have shown its overhead to be 20.77\% on average on 10 contemporary networks.
SEDATIVE ACTIVITY OF CELERY OIL CONSTITUENTS (1978)

ABSTRACT The central depressant activities of 3, n‐butylphthalide and a new compound, sedanenolide, were studied in mice. While neither compound affects ethanol sedation, they exhibit similar activities in both prolonging pentobarbital narcosis by prior administration of the test compounds and in inducing sleep immediately following recovery from a prior treatment with barbiturate. Weak sedative activity is also shown to reside in both compounds without potentiation.
A High Performance 20-42 GHz MMIC Frequency Multiplier with Low Input Drive Power and High Output Power (2006)

A 20-42GHz output frequency GaAs MMIC frequency doubler chip has been developed that requires low input drive power and produces high output power with high fundamental & harmonic suppression without any external filter. This developed chip has an integrated broadband single ended-in to differential-out active Balun with impedance inverter and a broadband waveform shaping circuit. The unique topology of developed Balun helps to produce high voltage swing at differential outputs at low input drive power with excellent amplitude and phase balance over the band. The differential outputs of active Balun are connected to balanced common source FETs and drive the balanced FETs in push-push configuration to generate second harmonics and reject fundamental and higher (odd) order harmonics. This creates a broadband frequency doubler with overlapping input and output frequencies, high conversion efficiency with good fundamental and higher odd harmonic rejection without any external Filter. The doubler work from -9 to +7 dBm. The output power of doubler is +17 to +18dBm in most of the band at Pin=+3dBm. Fundamental suppression is better than 50dBc to 34GHz and minimum 30dBc in the entire band. 3rd and 4th harmonic rejections are also better than 25dBc in most of the band. The phase noise of doubler is -137dBc/Hz at 100 kHz offset (fout=24GHz). The input return loss of doubler is better than 20dB in most of the band and output return loss varies from 10-15dB over the band. It works at Vd =4.5V, Id=100-225mA
Programming Deep Brain Stimulation (2007)

Deep brain stimulation (DBS) is a complex medical treatment. The success of thisintervention depends on a variety of components including proper patient selec-tion, accurate surgical placement of the electrode, effective programming of thestimulator and adequate follow-up medication management. While the formertwo are one-time events, the latter two are reoccurring interventions over the life-span of the therapy. As the strength of a chain is determined by its weakest link,the overall success of DBS is determined by its weakest component as well. Ingeneral, stimulator programming represents the weakest link and does not infre-quently break the chain, diminishing or eliminating potential benefits of DBS.Fortunately, programming is a reoccurring event and allows for correction orreprogramming, and hopefully improved outcome. While individual componentsof this therapy are performed by highly trained neurosurgeons and neurologists,programming is often relegated to health care professionals with inadequatetraining and experience. As a result, the full potential benefit of this therapy isnot always attained and the efficacy of DBS is potentially diminished.
Explaining and querying knowledge graphs by relatedness (2017)

We demonstrate RECAP, a tool that explains relatedness between entities in Knowledge Graphs (KGs) and implements a query by relatedness paradigm that allows to retrieve entities related to those in input. One of the peculiarities of RECAP is that it does not require any data preprocessing and can combine knowledge from multiple KGs. The underlying algorithmic techniques are reduced to the execution of SPARQL queries plus some local refinement. This makes the tool readily available on a large variety of KGs accessible via SPARQL endpoints. To show the general applicability of the tool, we will cover a set of use cases drawn from a variety of knowledge domains (e.g., biology, movies, co-authorship networks) and report on the concrete usage of RECAP in the SENSE4US FP7 project. We will underline the technical aspects of the system and give details on its implementation. The target audience of the demo includes both researchers and practitioners and aims at reporting on the benefits of RECAP in practical knowledge discovery applications.
Optical fibre spectrometer combined with a magnetic resonance sensor for multiple depth monitoring (2013)

Under some circumstances, it is necessary to do optical spectroscopy on a front surface while at the same time monitoring the presence of a hidden metallic layer. Here, a novel sensor system to do this based on the combination of a visible light optical fibre spectrometer with a magnetic resonance eddy current sensor is demonstrated. It is shown that the the eddy current sensor can probe a hidden metallic film placed up to 1 cm behind the dielectric front surface. The combination of two such detection principles allows one to probe layered materials at multiple depths, revealing their electromagnetic properties at different frequencies.
Logic-based Nonlinear Image Processing (2006)

This text provides insight into the design of optimal image processing operators for implementation directly into digital hardware. Starting with simple restoration examples and using the minimum of statistics, the book provides a design strategy for a wide range of image processing applications. The text is aimed principally at electronics engineers and computer scientists, but will also be of interest to anyone working with digital images
A Phase 1/2a Study Evaluating the Safety, Pharmacokinetics, and Efficacy of ABT-263 in Subjects with Refractory or Relapsed Lymphoid Malignancies. (2007)

Abstract Background: ABT-263 is a novel small molecule Bcl-2 family protein inhibitor that binds with high affinity (Ki ≤ 1 nM) to multiple antiapoptotic Bcl-2 family proteins including Bcl-XL, Bcl-2, Bcl-w, and Bcl-B. ABT-263 displays potent mechanism-based cytotoxicity (EC50 ≤ 1 mM) against human tumor cell lines derived from lymphoid malignancies and small cell lung cancer (SCLC). Pre-clinical experiments on primary patient derived chronic lymphocytic leukemia (CLL) samples with ABT-737, a first generation Bcl-2 family protein inhibitor, induced robust, concentration-dependent apoptosis. The anticipated ABT-263 associated toxicities are mechanism based, in particular, Bcl-XL mediated decrease in circulating platelet survival, Bcl-w mediated testicular toxicity, and Bcl-2 mediated effects on lymphocytes. ABT-263 is currently being investigated in 3 Phase 1/2a studies in patients with lymphoid malignancies, SCLC/solid tumors, and CLL. Methods: In this Phase 1/2a study of ABT-263 in subjects with lymphoid malignancies, the Phase 1 dose escalation portion of the study was designed to determine the maximum tolerated dose (MTD), dose limiting toxicity (DLT), and recommended Phase 2 dose (RPTD). For each 21-day cycle, subjects receive ABT-263 orally QD for 14 consecutive days followed by 7 days off drug. Pharmacokinetic (PK) assessment was performed at study initiation and on Day 14 of drug dosing. The Phase 2a portion of the study will evaluate ABT-263 at the RPTD in up to 40 subjects with follicular and aggressive NHL to obtain additional safety information and a preliminary assessment of efficacy. Results: Currently 17 subjects have been enrolled in the lymphoma study. Three subjects completed each of the 10, 20, 40, and 80 mg cohorts enrolled thus far. A Grade 3 DLT (URI resulting in hospitalization treated with antibiotics) occurred in the 160 mg cohort, thus the cohort was expanded to 6. Two patients with bulky SLL/CLL in the 40 and 160 mg cohorts had 95% and 64% tumor reductions after cycles 4 and 2, respectively, and continue on treatment. The PK profile of ABT-263 appeared to be linear between the 10 mg and 160 mg dose levels. The average terminal half-life of ABT-263 varied between 14 and 25 hours across all dose levels. ABT-263 reduced the platelet level in a dose-dependent manner. One subject experienced a Grade 3 thrombocytopenia (platelets 45K/uL) on C1D14, 4 hours post-dosing with 80 mg, resolving 8 hours post-dosing to a platelet count of 162 K/uL. The decreased platelet count did not result in any medical sequelae. Conclusions: ABT-263 is a novel, orally bioavailable and active small molecule Bcl-2 family protein inhibitor that has shown preliminary evidence of activity in lymphoid malignancies.
Spatially and temporally restricted expression of <i>Pax2</i> during murine neurogenesis (1990)

The expression of the murine paired-box-containing gene, Pax2, is examined in the developing central nervous system by in situ hybridization. Pax2 expression is detected along the boundaries of primary divisions of the neural tube. Initially, Pax2 is expressed in the ventricular zone in two compartments of cells on either side of the sulcus limitans and along the entire rhombencephalon and spinal cord. At later times, Pax2 is restricted to progeny cells that have migrated to specific regions of the intermediate zone. In the eye, Pax2 expression is restricted to the ventral half of the optic cup and stalk and later to the optic disc and nerve. In the ear, expression is restricted to regions of the otic vesicle that form neuronal components. The transient and restricted nature of Pax2 expression suggests that this murine segmentation gene homologue may also establish compartmental boundaries and contribute to the specification of neuronal identity, as do certain Drosophila segmentation genes.
Photo‐Rechargeable Battery Effect in First Generation Cationic‐Cyanine Dendrimers (2010)

A photobattery based on a cationic cyanine dendrimer is demonstrated. The battery can be recharged simply by exposure to light. The mechanism for charge storage and discharge is proposed.
Disposition of transdermally administered fentanyl in dogs (1996)

Transdermally administered fentanyl has the potential to be a clinically useful analgesic regimen in dogs, and further evaluation of its analgesic actions and potential side effects warranted
Acousto-optic modulators as unidirectional devices in ring lasers (1992)

Acousto-optic modulators can act as optical diodes and force the unidirectional single-axial-mode operation of ring lasers. We explain this effect in terms of the Doppler shift of the scattered light beams and present results of experiments in support of this theory.
Alkylations of Heterocyclic Ambident Anions II. Alkylation of 2-Pyridone Salts (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAlkylations of Heterocyclic Ambident Anions II. Alkylation of 2-Pyridone SaltsGeorge Hopkins, James Jonak , Harry Minnemeyer, and Howard TieckelmannCite this: J. Org. Chem. 1967, 32, 12, 4040–4044Publication Date (Print):December 1, 1967Publication History Published online9 September 2002Published inissue 1 December 1967https://pubs.acs.org/doi/10.1021/jo01287a600https://doi.org/10.1021/jo01287a600research-articleACS PublicationsRequest reuse permissionsArticle Views1442Altmetric-Citations100LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A new approach to the Etymology of English "Keelson" (1955)

A new approach to the Etymology of English "Keelson" Get access Donald B. Sands Donald B. Sands Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume CC, Issue jan, 1 January 1955, Pages 10–11, https://doi.org/10.1093/nq/CC.jan.10 Published: 01 January 1955
Hybrid Carrier Communication with Partial FFT Demodulation over Underwater Acoustic Channels (2013)

Recently, the partial Fast Fourier Transform (PFFT) has emerged as a promising demodulation scheme for the orthogonal frequency division multiplexing (OFDM) over underwater acoustic (UWA) channels. However, the effectiveness of OFDM in the receivers is impaired by inter-carrier interference (ICI) due to the significant time variations under UWA channels. In this letter, we consider the weighted-type fractional Fourier transform (WFRFT)-based hybrid carrier (HC) modulation system with PFFT demodulation for UWA communication. The residual ICI, after PFFT demodulation and weight compensation, can be further suppressed in the WFRFT domain. Numerical results are presented to demonstrate the superiority of HC scheme with PFFT demodulation over the single carrier (SC) and OFDM schemes with PFFT demodulation at a very moderate complexity.
Direct Quantitation of the Numbers of Individual Penicillin-Binding Proteins per Cell in <i>Staphylococcus aureus</i> (2002)

The penicillin-binding proteins (PBPs) are a set of enzymes that participate in bacterial peptidoglycan assembly. The absolute numbers of each PBP were determined by direct measurement and have been reported for two Staphylococcus aureus strains, RN4220 (methicillin-sensitive S. aureus) and RN450M (methicillin-resistant S. aureus). From the specific activity of the labeled penicillin and the absolute number of disintegrations per minute, and from the number of CFU per milliliter calculated from proteins and optical density, a determination of the number of PBPs per cell was made. These numbers ranged from approximately 150 to 825 PBPs/cell and represent the first direct determination of absolute numbers of PBPs in S. aureus.
How to Better Measure Hedonic Residential Property Price Indexes (2016)

Hedonic regressions are used for property price index measurement to control for changes in the quality-mix of properties transacted. The paper consolidates the hedonic time dummy approach, characteristics approach, and imputation approaches. A practical hedonic methodology is proposed that (i) is weighted at a basic level; (ii) has a new (quasi-) superlative form and thus mitigates substitution bias; (iii) is suitable for sparse data in thin markets; and (iv) only requires the periodic estimation of hedonic regressions for reference periods and is not subject to the vagrancies of misspecification and estimation issues.
ApoE Polymorphism May Determine Low-Density Lipoprotein Cholesterol Level in Association with Obesity and Metabolic Syndrome in Postmenopausal Korean Women (2011)

This study suggests that obesity or metabolic syndrome risk should be effectively managed in ApoE3 isomform groups to reduce serum LDL in postmenopausal Korean women.
Serotonin, <scp>l</scp> ‐tryptophan, and tryptamine are effective inhibitors of the amino acid transport system PAT1 (2005)

The proton-coupled amino acid transporter PAT1, cloned recently from brain and intestine, mediates the uphill transport of l- and d-proline, l-alanine, glycine, taurine, d-serine, GABA, and many other related compounds and drugs. Here we describe the novel finding that l-tryptophan and its derivatives tryptamine, 5-hydroxy-l-tryptophan, serotonin, and indole-3-propionic acid strongly inhibit H+-dependent l-[3H]proline uptake into Caco-2 cells with inhibition constants (K(i)) of 0.9 to 6.1 mM. Uptake of l-[3H]tryptophan into Caco-2 cells on the other hand was not inhibited by l-proline. Whereas PAT1 substrates produced significant changes in a membrane potential assay for electrogenic transport in Caco-2 cells, l-tryptophan, tryptamine, and 5-hydroxy-l-tryptophan failed to alter membrane voltage. When PAT1 was expressed in Xenopus laevis oocytes and analyzed by the two-electrode voltage clamp technique, glycine elicited high inward currents that were dependent on membrane potential but no currents were observed with l-tryptophan, tryptamine, 5-hydroxy-l-tryptophan, or serotonin. Although not transported electrogenically by PAT1, l-tryptophan and its derivatives inhibited glycine-evoked currents dose-dependently. We conclude that serotonin, l-tryptophan, and tryptamine bind to PAT1 with potencies similar to the prototype substrates, inhibit transport function but are not transported by this carrier protein. They may be considered as the carriers' naturally occurring inhibitors that may alter the transport function of PAT1.
An Alternative to Sand-Control Screens: Is Permeable Cement a Viable Option? (2008)

Summary The search for a cost-effective alternative to screens has been intensive in the sand-control field. Different systems have been proposed in the past, including various solutions based on permeable cement, but none of them have made a real breakthrough. This paper presents a new permeable-cement system that has significant advantages over previous systems. In particular, this permeable cement was formed in a one-stage process, eliminating the need for a subsequent treatment to generate permeability. This permeable-cement system also has adequate strength and sufficient permeability for several sand-control applications. However, the durability of the permeable cement was evaluated and found to be poor. Some suggestions are made for possible applications of the permeable cement for both primary and remedial sand-control applications.
Reversible Root Tip Rotation in <i>Arabidopsis</i> Seedlings Induced by Obstacle-Touching Stimulus (1990)

In soil, downwardly growing plant roots frequently alter their growth direction to escape obstacles that lie in their paths. This response has been analyzed with a simple system that provides a constant obstacle-touching stimulus to root tips of young seedlings of Arabidopsis thaliana. On the surface of agar plates, which were set at an angle of 45 degrees to the vertical, the roots exhibit a wavy growth pattern that is caused by periodic reversion of rotation of the root tip. A set of mutants with abnormal wavy growth was used to demonstrate that at least six genes are involved in this stimulus-response interaction.
5<sup>th</sup> International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention: summary of key research and implications for policy and practice – Clinical sciences (2010)

Studies in several sub-Saharan African countries demonstrated that the expansion of antiretroviral therapy (ART) access is not only beneficial for people living with HIV, but also results in significant declines in tuberculosis and malaria incidence and prevalence, bolstering arguments for earlier and increased ART access and contributing to a growing understanding of co-epidemic dynamics. Several studies demonstrated that using standard triple-drug ART in resource-limited settings can reduce vertical transmission by as much as less than 1% if continued throughout breastfeeding.The Nevirapine Resistance Study (NEVEREST) results provided proof of concept that nevirapine could be used as part of a paediatric second-line regimen, despite exposure to nevirapine prophylaxis for vertical transmission, following successful suppression on a lopinavir/ritonavir-based regimen. A South African study found that high pre-treatment levels of inflammatory and coagulation markers were strong predictors of death, reflecting similar findings in high-income countries and reinforcing the shift towards viewing HIV as a chronic, inflammatory disease. An early study of a new integrase inhibitor (S/GSK1349572) indicated strong potency and limited cross-resistance with raltegravir, the only integrase inhibitor currently approved for treatment.
PAK Is Essential for RAS-Induced Upregulation of Cyclin D1 During the G1 to S Transition (2004)

Oncogenic RAS mutants such as v-Ha-RAS induce cell cycling, in particular the G1 to S transition, by upregulating cyclin D1 and downregulating p27, an inhibitor for cyclin-dependent kinases (CDKs). PI-3 kinase appears to be involved in the regulation of both cyclin D1 and p27. In this report, using two distinct inhibitors specific for PAK1-3 (CEP-1347 and WR-PAK18), we present the first evidence indicating that the PIX/Rac/CDC42-dependent Ser/Thr kinases PAK1-3, acting downstream of PI-3 kinase and upstream of the Raf/MEK/ERKs kinase cascade, is essential for RAS-induced upregulation of cyclin D1, but not downregulation of p27. Since these PAK-inhibitors block selectively the malignant growth of RAS transformants, in which PAK1 is constitutively activated, but not normal cell growth, it is suggested that RAS transformants are addicted to the high levels of PAK1 for their malignant entry to S phase.