gebhart/patrepeval huggingface dataset:
Pharmacologic Therapy in Growth Hormone Disorders and the Heart (2007)

Growth hormone (GH)/insulin-like growth factor-I (IGF-I) axis is not only involved in the regulation of somatic growth but also has important physiological functions in adults. Several studies have shown that GH deficiency in adults is associated with abnormalities in body composition, metabolic derangements, and suboptimal physical performance. Furthermore, GH/IGF-I axis plays an important role in the maintenance of heart structure and function. Until recently, GH therapy was only used to treat short stature children, with or without established GH deficiency, and it remains common practice to discontinue GH replacement therapy when final height is achieved. Acromegaly, entity characterized by GH hypersecretion, is associated with an increased risk of premature death. Cardiac complications are known to be major determinants of the shortened life expectancy. Treatment of acromegaly accounts for a substantial decrease in morbidity and mortality. Surgery, radiation therapy and bromocriptine have only been able to reduce GH levels to normal levels in 10-30% of patients. The synthesis of somatostatin analogs has provided a new approach to acromegaly treatment. These drugs reduce GH and IGF-I levels in 80% of cases and normalize them in 40-60% of cases. Finally, GH/IGF-I system improves left ventricular systolic function and has also indirect effects on the cardiovascular system, mainly as a consequence of the peripheral vasodilatation. These effects are important in the understanding of the potential role of GH on improving ventricular systolic dysfunction and point to the use of GH as a potential therapy for chronic heart failure. The aim of the present review is to provide an update overview describing the role of GH on acromegaly, adult GH deficiency and heart failure, as well as the influence of GH-based therapy on heart structure and function.
Computer-Aided Design of Antimicrobial Peptides: Are We Generating Effective Drug Candidates? (2020)

Antimicrobial peptides (AMPs), especially antibacterial peptides, have been widely investigated as potential alternatives to antibiotic-based therapies. Indeed, naturally occurring and synthetic AMPs have shown promising results against a series of clinically relevant bacteria. Even so, this class of antimicrobials has continuously failed clinical trials at some point, highlighting the importance of AMP optimization. In this context, the computer-aided design of AMPs has put together crucial information on chemical parameters and bioactivities in AMP sequences, thus providing modes of prediction to evaluate the antibacterial potential of a candidate sequence before synthesis. Quantitative structure-activity relationship (QSAR) computational models, for instance, have greatly contributed to AMP sequence optimization aimed at improved biological activities. In addition to machine-learning methods, the <i>de novo</i> design, linguistic model, pattern insertion methods, and genetic algorithms, have shown the potential to boost the automated design of AMPs. However, how successful have these approaches been in generating effective antibacterial drug candidates? Bearing this in mind, this review will focus on the main computational strategies that have generated AMPs with promising activities against pathogenic bacteria, as well as anti-infective potential in different animal models, including sepsis and cutaneous infections. Moreover, we will point out recent studies on the computer-aided design of antibiofilm peptides. As expected from automated design strategies, diverse candidate sequences with different structural arrangements have been generated and deposited in databases. We will, therefore, also discuss the structural diversity that has been engendered.
Survivors of Childhood Cancer in the United States: Prevalence and Burden of Morbidity (2015)

Efforts to understand how to effectively decrease morbidity burden and incorporate effective care coordination and rehabilitation models to optimize longevity and well-being in this population should be a priority.
Efficacy of aromatherapy (Lavandula angustifolia) as an intervention for agitated behaviours in Chinese older persons with dementia: a cross‐over randomized trial (2007)

In summary, lavender is effective as an adjunctive therapy in alleviating agitated behaviours in Chinese patients with dementia. In a patient population particularly vulnerable to side effects of psychotropic medications, aromatherapy using lavender may offer an alternative option.
New Cytotoxic Tetrahydrofuran- and Dihydrofuran-Type Lignans from the Stem of<i>Beilschmiedia tsangii</i> (2006)

Five new compounds including two tetrahydrofuran-type lignans, beilschmin A and beilschmin B, a dihydrofuran-type lignan, beilschmin C, and two 1-phenylbutyl benzoates, tsangin A and tsangin B, together with thirteen known compounds have been isolated from the stem of Beilschmiedia tsangii. The structures of these new compounds were determined through spectral analyses. Among the isolates, beilschmin A (1), beilschmin B (2), beilschmin C (3), tsangin A (4), tsangin B (5), 2,6,11-trimethyldodeca-2,6,10-triene (14), alpha-tocopherylquinone (17), and alpha-tocospiro B (18) were cytotoxic (IC (50) values < 4 microg/mL) in P-388 and/or HT-29 cell lines in vitro.
Establishment of <i>Porphyromonas gingivalis</i> Heat-shock-protein-specific T-cell Lines from Atherosclerosis Patients (2002)

Human atherosclerotic plaques contain heat-shock proteins which may serve as potential targets of the immune response in atherosclerosis. Since periodontal infections are suggested as risk factors for the development of cardiovascular diseases, we undertook the present study to evaluate the T-cell immune responses specific to Porphyromonas gingivalis (P. gingivalis) heat-shock protein (hsp)60 in patients suffering from atherosclerosis. Anti-P. gingivalis hsp60 IgG antibody titers were elevated in all patients. We could establish P. gingivalis hsp-specific T-cell lines from the atheroma lesions and the peripheral blood. The T-cell lines were a mixture of CD4+ and CD8+ cells producing the cytokines characteristic of both Th1 and Th2 subsets. The present findings suggest that the T-cell immune response specific to P. gingivalis hsp60 may be involved in the immunopathologic process of atherosclerotic diseases.
Reactive oxygen species in oncogenic transformation (2003)

Ever since ROS (reactive oxygen species) were shown to meet the criteria of true signalling molecules, such as regulated production and a specific biological function, many efforts have been made to understand the precise role of ROS. The function of ROS in pathological mechanisms is taking a more and more central role in various fields of biomedical research, including neurobiology, cardiology and cancer. An elevated oxidative status has been found in many types of cancer cells, and the introduction of chemical and enzymological antioxidants can inhibit tumour cell proliferation, pointing to a critical role of ROS in mediating loss of growth control. The present review describes ROS-regulated mechanisms that are associated with cancer and tumour invasiveness. The cellular processes that are linked to these ROS functions are mitogenic signalling and cell motility, while ROS have also been implicated in apoptosis and cellular senescence, two mechanisms regarded as being anti-tumorigenic. This "two-faced" character of free radicals will be discussed and placed in the context of the physiological conditions of the tumour cell, the different molecular backgrounds, and the specific ROS. More detailed understanding of the signalling pathways regulated by ROS in tumour cells will open up new prospects for chemo- or gene-therapeutic interventions.
Slow-Light Waveguides with Mode Degeneracy: Rotation-Induced Super Structures and Optical Gyroscopes (2006)

We study wave propagation in a rotating slow-light structure with mode degeneracy. The rotation effectively induces a super-structure that significantly modifies the structure’s dispersion relation. Applications to ultra-sensitive integrated optical gyroscopes are discussed.
Postconditioning with a volatile anaesthetic in alveolar epithelial cells<i>in vitro</i> (2007)

Acute lung injury is a common complication in critically ill patients. The present study examined possible immunomodulating effects of the volatile anaesthetic sevoflurane on lipopolysaccharide (LPS)-stimulated alveolar epithelial cells (AEC) in vitro. Sevoflurane was applied after the onset of injury, simulating a "postconditioning" scenario. Rat AEC were stimulated with LPS for 2 h, followed by a 4-h co-exposure to a CO(2)/air mixture with sevoflurane 2.2 volume %; control cells were exposed to the CO(2)/air mixture only. Cytokine-induced neutrophil chemoattractant-1, monocyte chemoattractant protein-1, intercellular adhesion molecule-1, as well as the potential protective mediators inducible nitric oxide synthase (iNOS)2 and heat shock protein (HSP)-32, were analysed. Additionally, functional assays (chemotaxis, adherence and cytotoxicity assay) were performed. A significant reduction of inflammatory mediators in LPS-stimulated, sevoflurane-exposed AEC was found, leading to reduced chemotaxis, neutrophil adherence and neutrophil-induced AEC killing. While iNOS2 was increased in the sevoflurane group, blocking experiments with iNOS2 inhibitor did not affect sevoflurane-induced decrease of inflammatory mediators and AEC killing. Interestingly, sevoflurane treatment also resulted in an enhanced expression of HSP-32. The data presented in the current study provide strong evidence that anaesthetic postconditioning with sevoflurane mediates cytoprotection in the respiratory compartment in an in vitro model of acute lung injury.
Performance and Variability Studies of InGaAs Gate-all-Around Nanowire MOSFETs (2013)

Furthering Si CMOS scaling requires development of high-mobility channel materials and advanced device structures to improve the electrostatic control. We demonstrate the fabrication of gate-all-around (GAA) indium gallium arsenide (InGaAs) MOSFETs with highly scaled atomic-layer-deposited gate dielectrics. InGaAs, with its high electron mobility, allows higher drive currents and other on-state performance compared to silicon. The GAA structure provides superior electrostatic control of the MOSFET channel with outstanding off-state performance. A subthreshold slope of 72 mV/dec, electron mobility of 764 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> /V·s, and an on-current of 1.59 mA/μm are demonstrated, for example. Variability studies on on-state and off-state performances caused by the number of nanowire channels are also presented.
A Simple Method for Improving Stereopsis (1990)

Presented here is a method for the improvement of stereopsis. It is based on covering and uncovering one eye in a particular way. A complete program for the improvement of stereopsis is described. This includes an uncovering technique, the use of an Orthofuser, and the observation of specular reflections. Examples are given which demonstrate the effectiveness of the method. Persons who are capable of stereopsis but who use it selectively or not at all in everyday life (paradoxical stereopsis) are particularly easy to cure.
Gemcitabine chemoresistance in pancreatic cancer: Molecular mechanisms and potential solutions (2009)

Ductal pancreatic adenocarcinoma is associated with a very poor prognosis and most patients are given palliative care. Chemotherapy in the form of gemcitabine has been found to reduce disease-related pain, and the otherwise frequently occurring weight changes, to increase Karnofsky performance status and quality of life and has also resulted in a modest improvement in survival time. The intracellular uptake of gemcitabine is dependent on nucleoside transporters, predominantly human equilibrative nucleoside transporter-1 (hENT-1), which is over-expressed in human pancreatic adenocarcinoma cells. Cellular resistance to gemcitabine can be intrinsic or acquired during gemcitabine treatment. One of the mechanisms is a decrease in hENT-1 expression. Modifications of gemcitabine not rendering it dependent on the nucleoside transporter may be a successful future mode of chemotherapy treatment, and determination of the nucleoside receptor status at the time of diagnosis could potentially also contribute to a more targeted therapy in the future.
Replacement by <i>Drosophila melanogaster</i> Protamines and Mst77F of Histones during Chromatin Condensation in Late Spermatids and Role of Sesame in the Removal of These Proteins from the Male Pronucleus (2005)

Chromatin condensation is a typical feature of sperm cells. During mammalian spermiogenesis, histones are first replaced by transition proteins and then by protamines, while little is known for Drosophila melanogaster. Here we characterize three genes in the fly genome, Mst35Ba, Mst35Bb, and Mst77F. The results indicate that Mst35Ba and Mst35Bb encode dProtA and dProtB, respectively. These are considerably larger than mammalian protamines, but, as in mammals, both protamines contain typical cysteine/arginine clusters. Mst77F encodes a linker histone-like protein showing significant similarity to mammalian HILS1 protein. ProtamineA-enhanced green fluorescent protein (eGFP), ProtamineB-eGFP, and Mst77F-eGFP carrying Drosophila lines show that these proteins become the important chromosomal protein components of elongating spermatids, and His2AvDGFP vanishes. Mst77F mutants [ms(3)nc3] are characterized by small round nuclei and are sterile as males. These data suggest the major features of chromatin condensation in Drosophila spermatogenesis correspond to those in mammals. During early fertilization steps, the paternal pronucleus still contains protamines and Mst77F but regains a nucleosomal conformation before zygote formation. In eggs laid by sesame-deficient females, the paternal pronucleus remains in a protamine-based chromatin status but Mst77F-eGFP is removed, suggesting that the sesame gene product is essential for removal of protamines while Mst77F removal is independent of Sesame.
Stress in metal lines under passivation; comparison of experiment with finite element calculations (1991)

The elastic strain in Al-0.5% Cu metal lines under silicon nitride passivation has been determined by x-ray diffraction. The experimental stress tensor calculated from these strain values is in excellent agreement with the results of a finite element model calculation. The intrinsic stress in the dielectric plays no role in influencing the stress in the metal; only thermal stress effects are important.
Cafeína e esporte (2000)

A cafeina e considerada pela Organizacao Mundial daSaude como uma droga estimulante do sistema nervosocentral, juntamente com as anfetaminas, a nicotina e a co-caina. Sao denominadas drogas uma serie de substânciaspsicoativas que podem ser objeto de abuso. Todas sao ca-pazes de modificar uma ou varias funcoes do nosso orga-nismo.EFEITOS E MECANISMOS DE ACAOA cafeina (trimetilxantina) e uma droga psicotropica dogrupo dos estimulantes do sistema nervoso central. Emgeral, os seus efeitos sobre o organismo consistem em au-mentar o estado de alerta e reduzir a sensacao de fadiga,podendo aumentar a capacidade para realizar determina-das tarefas. A cafeina tambem possui efeitos reforcadoresque podem ser parcialmente devidos a ativacao do sistemadopaminergico. Outra acao importante da cafeina e o es-timulo a diurese, devido – entre outros mecanismos – aoaumento de glomerulos em funcionamento e do fluxo san-guineo renal, ao elevar o gasto cardiaco.Da mesma forma que outras xantinas, a cafeina possuiefeitos inotropicos, taquicardizantes, broncodilatadores eestimulantes da secrecao gastrica. Em doses maiores, pro-duz excitacao, ansiedade e insonia e em consumidores ha-bituais se desenvolve tolerância com necessidade de au-mentar o consumo para obter os efeitos iniciais. A inter-rupcao do uso produz uma sindrome de abstinencia comcefaleia, irritabilidade e letargia.Ao nivel celular, a cafeina e um antagonista competitivodos receptores de adenosina e provavelmente atua tambemdiretamente ao nivel de receptores, para potenciar a libera-cao do calcio do reticulo sarcoplasmatico, pelo desacopla-INTRODUCAOA cafeina, um alcaloide de xantina, foi identificada pelaprimeira vez no cafe. A descoberta dos seus efeitos parareduzir a fadiga e aumentar o estado de alerta e atribuida aum monge etiope. Este monge ouviu de um pastor sobre oefeito produzido pelas sementes do cafe nas suas cabras,decidindo preparar uma bebida com elas, para poder pas-sar a noite acordado em oracao.O habito de beber cafe se desenvolveu na Arabia duran-te os seculos XV e XVI, tendo sido introduzido na Europaocidental atraves da Turquia, no final do seculo XVI. Ocultivo do cafe teve inicio no Iemen, proximo a Meca, noseculo XIX, onde tambem se aperfeicoou a forma de pre-parar a bebida com o grao de cafe. Atualmente, a metadedo cafe produzido e cultivado em Sao Paulo, Brasil.Embora a sua popularidade seja indiscutivel, semprehouve divisao quanto aos efeitos beneficos do cafe. Osconsumidores habituais de cafe (cinco ou mais xicaras pordia) relatam que a abstencao causa-lhes irritabilidade, in-quietacao, nervosismo, cefaleia e dificuldade de rendimentono trabalho. Em um estudo duplo cego com cafeina e umplacebo, pode-se verificar que tais sintomas eram devidosa supressao da cafeina. A cafeina aumentou o estado dealerta, reduziu a irritabilidade e produziu uma sensacao desatisfacao, embora uma dose semelhante em individuos naoconsumidores habituais de cafe tenha produzido irritabili-dade, nervosismo e dispepsia. Desta forma, pode-se inter-pretar que o consumo habitual de grandes doses de cafeinaproduz tolerância e dependencia
High-accuracy length metrology using multiple-stage swept-frequency interferometry with laser diodes (1998)

The optical length of a 1 m Fabry-Pérot etalon has been determined by swept-frequency interferometry using laser diodes. The method involves progressively building up the measurement accuracy using frequency sweeps over increasing ranges, from 150 MHz (one optical fringe) to 19 GHz and 7 THz. The 7 THz sweep is referenced to the splitting of the rubidium D lines at 780 nm and 795 nm. The result from the 7 THz sweep is sufficiently accurate to use the known frequency of either end point of the scan to determine the length to a few parts in , without the need for any further measurement. The scope for further development of this technique to a range of interferometric systems is discussed.
Influence of support on the performance of coal liquid hydrotreating catalysts (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInfluence of support on the performance of coal liquid hydrotreating catalystsRobert L. McCormick, Julia A. King, Todd R. King, and Henry W. Haynes Jr.Cite this: Ind. Eng. Chem. Res. 1989, 28, 7, 940–947Publication Date (Print):July 1, 1989Publication History Published online1 May 2002Published inissue 1 July 1989https://pubs.acs.org/doi/10.1021/ie00091a009https://doi.org/10.1021/ie00091a009research-articleACS PublicationsRequest reuse permissionsArticle Views95Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Peroxide Route Towards Low Temperature Synthesis of LiNbO3: An Environmentally Benign Approach (2004)

Powders of LiNbO3 were synthesized by novel peroxide route based on reaction of niobium peroxide and lithium hydroxide. A pH of 11 was found to provide optimum condition for the formation of peroxo niobium precursor complex [Nb(O2)4]3-. The replacement of peroxide ligand was favored by increasing the reaction temperature above ambient. This method demonstrated its efficacy in obtaining pure and homogeneous crystalline LiNbO3 powders at reduced temperature (400°C) without involvement of organic substance. The crystalline phase was characterized via powder X-ray diffraction and Infrared, Raman spectroscopy. SEM micrographs enabled in detecting the formation of inverse opal of LiNbO3. For comparison LiNbO3 was also prepared by amorphous complex method independently and characterized. The peroxide approach presented here gives an alternative for the preparation of multi component oxides free from organics and chlorides.
Characterization of PvuRts1I endonuclease as a tool to investigate genomic 5–hydroxymethylcytosine (2011)

In mammalian genomes a sixth base, 5-hydroxymethylcytosine ((hm)C), is generated by enzymatic oxidation of 5-methylcytosine ((m)C). This discovery has raised fundamental questions about the functional relevance of (hm)C in mammalian genomes. Due to their very similar chemical structure, discrimination of the rare (hm)C against the far more abundant (m)C is technically challenging and to date no methods for direct sequencing of (hm)C have been reported. Here, we report on a purified recombinant endonuclease, PvuRts1I, which selectively cleaves (hm)C-containing sequences. We determined the consensus cleavage site of PvuRts1I as (hm)CN(11-12)/N(9-10)G and show first data on its potential to interrogate (hm)C patterns in mammalian genomes.
Comprehensive study of several general and type-specific primer pairs for detection of human papillomavirus DNA by PCR in paraffin-embedded cervical carcinomas (1996)

We have compared the efficacies of three general primer pairs for the detection of human papillomavirus (HPV) DNA in formaldehyde-fixed paraffin-embedded carcinomas. The use of these primer pairs leads to underestimates of the HPV prevalence (GP5/6, 61.1%; CPI/IIG, 57.4%; MY09/11, 46.9%; combined, 72.8%). The efficacy of each primer pair seemed to be inversely correlated to the length of the amplimer produced. By using newly developed type-specific primer pairs (amplimer length, approximately 100 bp), an increase in HPV DNA detection (87.6%) was found.
Boat Navigation and Safeguard of Passenger's Over Flood Disaster (2018)

The advancement of effective surge flood disaster framework turned out to be additionally testing from most recent couple of years. Many accidents caution made people's life in danger when it comes to flood accidents which is natural disaster, cannot be stopped but can able to make possible for the protection of people's life. The main aim is to develop a versatile and automatic system for detecting the obstacle by using ultrasonic sensor and controls the boat directions by using Bluetooth module. By using water level sensor, detects flood disaster and provides protection by enclosing the boat within the fraction of seconds. Once it get enclosed, Oxygen module are used to provide oxygen to survive the passenger's life and awakes them through a buzzer and sends the information through a Global System for Mobile Communication (GSM) via SMS By utilizing IP web camera, takes the live gushing video of the encompassing things that can be viewed as a recorded/live video on the PC. This system will help to drive the boat in the required direction to avoid the obstacle or the opposite boat collision. And it concludes that there is a possibility to rescue the affected people at the time of flood.