gebhart/patrepeval huggingface dataset:
SALP16, a gene induced in Ixodes scapularis salivary glands during tick feeding. (2000)

Guinea pigs infested with Ixodes scapularis acquire antibody-mediated resistance to tick bites, a phenomenon known as tick-immunity. An I. scapularis salivary gland cDNA expression library was therefore probed with sera from tick-immune guinea pigs to identify antigens that elicit humoral responses in the host. Sera from sensitized guinea pigs strongly recognized 3 of 4,500 library clones in an initial screening. The open reading frames of all 3 clones encoded a putative 16.4-kD acidic protein, designated Salp16, with an N-terminal signal sequence and signal peptidase cleavage sites specific for secretory proteins. The salp16 mRNA and Salp16 protein were detected in the salivary glands of engorged, but not unfed, nymphal and adult ticks, and Salp16 was also found in the saliva of engorged ticks. Immunization with recombinant Salp16 induced high antibody titers in guinea pigs, but did not elicit tick-immunity. Salp16 is the first feeding inducible gene that has been cloned from L. scapularis. Molecular characterization of I. scapularis salivary antigens that are induced upon tick feeding should help to facilitate our understanding of tick-host interactions.
Radiosensitivity of ataxia-telangiectasia, X-linked agammaglobulinemia, and related syndromes using a modified colony survival assay. (1994)

We used a modified colony survival assay to measure the sensitivity to ionizing radiation of more than 50 lymphoblastoid cell lines from normal individuals and from patients with ataxia-telangiectasia, Nijmegen breakage syndrome variants, and X-linked agammaglobulinemia. All of these disorders are associated with an increased frequency of cancer. Lymphoblastoid cell lines from patients with ataxia-telangiectasia complementation groups A, C, D, and E; ATFresno; Nijmegen breakage syndrome variants V1 and V2; and X-linked agammaglobulinemia showed marked radiosensitivity, whereas ataxia-telangiectasia heterozygotes were similar to controls. Friedreich's ataxia is not associated with increased cancer risk; lymphoblastoid cell lines from two such patients showed normal radiosensitivity. Taken together, these results suggest that some forms of X-ray sensitivity and cancer susceptibility share a common mechanism, such as an enzyme that is necessary both for the repair of radiation damage to DNA and for gene rearrangements during V(D)J recombination.
Polymyxa betae zoospores as vectors of beet necrotic yellow vein furovirus<sup>1</sup> (1989)

When beet seedlings exposed as bait plants in infested soil were placed in a nutrient solution, they released Polymyxa betae zoospores, infected with beet necrotic yellow vein furovirus. The roots produced the first zoospores 5 days after the start of soil baiting. When seedlings were inoculated with zoospore suspensions, infection occurred within 5 min and reached a maximum in 30 min. The suspensions remained infectious for at least 2 h after removal of the bait plants from which the zoospores were released. So many spores were released into the suspension that disease transmission could be obtained within half an hour from an infected plant to a healthy plant, placed together into fresh medium. Suspensions could be diluted 1/16 with nutrient solution without any loss of infectivity, whereas 1/4 dilution with tap water resulted in a complete loss of infectivity.
Optical interconnection as an IP macro of a CMOS library (2002)

With the aim of producing a switch LSI with several-hundred-Gb/s-class throughput, we first developed LAN-LSIs with 10-Gb/s-class optical input/output (I/O) buffer. The optical I/O buffer was supplied as a set consisting of an optical-electrical package, soft or hard macros of the optical interface, and library files for a targeted CMOS technology. Using such library files, system LSI designers can implement an optical interface in their chips in a conventional design manner.
Impaired endothelial barrier function in apolipoprotein M‐deficient mice is dependent on sphingosine‐1‐phosphate receptor 1 (2016)

Apolipoprotein M (ApoM) transports sphingosine-1-phosphate (S1P) in plasma, and ApoM-deficient mice (Apom(-/-)) have ∼50% reduced plasma S1P levels. There are 5 known S1P receptors, and S1P induces adherens junction formation between endothelial cells through the S1P1 receptor, which in turn suppresses vascular leak. Increased vascular permeability is a hallmark of inflammation. The purpose of this study was to explore the relationships between vascular leakage in ApoM deficiency and S1P1 function in normal physiology and in inflammation. Vascular permeability in the lungs was assessed by accumulation of dextran molecules (70 kDa) and was increased ∼40% in Apom(-/-) mice compared to WT (C57Bl6/j) mice. Reconstitution of plasma ApoM/S1P or treatment with an S1P1 receptor agonist (SEW2871) rapidly reversed the vascular leakage to a level similar to that in WT mice, suggesting that it is caused by decreased plasma levels of S1P and reduced S1P1 stimulation. In a carrageenan-induced model of inflammation, Apom(-/-) mice had increased vascular leakage compared with that in WT mice. Adenoviral overexpression of ApoM in Apom(-/-) mice decreased the vascular leakage compared to adenoviral overexpression of green fluorescent protein. The study suggests that vascular leakage of albumin-sized particles in ApoM deficiency is S1P- and S1P1-dependent and this dependency exacerbates the response to inflammatory stimuli.-Christensen, P. M., Liu, C. H., Swendeman, S. L., Obinata, H., Qvortrup, K., Nielsen, L B., Hla, T., Di Lorenzo, A., Christoffersen, C. Impaired endothelial barrier function in apolipoprotein M-deficient mice is dependent on sphingosine-1-phosphate receptor 1.
Selective Isomerization of <i>cis</i>-Stilbene by Non-Resonant Two-Photon Excitation (1995)

Abstract Non-resonant two-photon excitation induced dramatical change in the photoreaction pathways of stilbenes. Typically, irradiation of cis-stilbene with 532 nm laser pulses caused only isomerization to trans-stilbene in hexane at room temperature; the cyclization to dihydrophenanthrene was completely suppressed.
Efficient Optical Trapping and Visualization of Silver Nanoparticles (2008)

We performed efficient optical trapping combined with sensitive optical detection of individual silver nanoparticles. The particles ranging in size from 20 to 275 nm in diameter were trapped in three dimensions using low laser power by minimizing spherical aberrations at the focus. The optical forces were quantified, and we found that the larger the particle, the stronger the optical force. The particles were imaged by an additional strongly scattered laser.
Store Buffers : implementing single cycle store instructions in write-through, write-back and set associative caches (1994)

Thesis (B.S. and M.S.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1994.
A computationally efficient approach for the design of RF power amplifiers (2002)

A computationally efficient procedure for the design of RF power amplifiers is presented. The proposed approach allows for the identification of "near-optimal" source and load terminations of the amplifier stage providing maximum output power under assigned linearity, minimum gain and other possible constraints. The design procedure is completely based on closed form numerical computations, without requiring non linear optimisations as normally happens in standard design approaches. A single-stage 2.4 GHz amplifier prototype has been designed and manufactured in Silicon BJT MMIC technology, according to the criteria provided by the new methodology. Experimental results are in good agreement with simulations and confirm the validity of the proposed approach.
Rate-Distortion Optimized I-Slice Selection for Low Delay Video Transmission (2007)

Rate smoothing is essential for achieving lower delay when transmitting real-time video over the network. Recently, "explicit slice-based mode selection" (ESM) is proposed as a new way of achieving this goal together with its inherent quality smoothness and error resilience features. However previous studies focus on the practical aspects and do not address an optimized solution. In this paper, we propose a rate-distortion (RD) optimized solution for finding the best location and size of the intra-coded slices. The experimental results show that for a target bit rate the optimized scheme is able to offer performance close to that of mode selection on a macroblock level, over wireless channels with different packet loss rates. Moreover, the optimized ESM algorithm provides significant advantages of granular bit stream prioritization for network transmission. However, the RD based optimization is in general computationally expensive. We therefore propose a heuristic approach which incorporates both channel statistics and sequence characteristics. Results show that it yields close to optimal performance at lower complexity.
The hemostatic effect of endoscopic sodium hyaluronate injection in peptic ulcer bleeding. (2007)

Sodium Hyaluronate is an excellent candidate agent for endoscopic injection therapy because of its convenience and safety. Further prospective randomized trials with other hemostatic methods are needed.
Synthesis and Spectroscopic Properties of Non-Symmetrical Benzo-Annulated Porphyrazines and Their Metal Complexes (2002)

New highly stable benzo-fused m-trifluoromethylphenyl porphyrazines and their complexes with Mg and In were synthesized by cross-condensation of phthalonitrile and bis(m-trifluoromethylphenyl)fumaronitrile. Their 1H and 13C NMR spectra were recorded and described. The Q- and B-bands in the UV/Vis spectra of the metal complexes show the characteristic splitting upon consecutive benzo-annulation. The strong variation of spectral features upon benzo-fusing and metallation/demetallation, as well as the good solubility of the metal complexes in organic solvents, make these materials potentially valuable for optical applications including nonlinear optics. (© Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002)
Sound Dispersion in Substituted Methane—Inert Gas Mixtures (1963)

Binary halomethane—noble gas mixtures were examined ultrasonically. The methanes used were CF4, CHF3, and CCl2F2 and the noble gases were Ar, Ne, and He. Results obtained show that the reciprocal relaxation times for these mixtures vary linearly with the concentration. Also, Ar—X collisions are less effective, He—X collisions are much more effective, and Ne—X collisions differ little from X—X collisions in vibrational energy transfer. X represents the dispersive gas. Theoretical values of Z10AB, the mean collision lifetime of an A molecule in an otherwise pure gas of B molecules, were calculated according to the Schwartz, Slawsky, and Herzfeld theory. Intermolecular potentials appropriate for the treatment of the data were examined, and it was found that the Lennard-Jones 6:12 potential was appropriate for the noble gases, and the 7:28 form was appropriate for the halomethanes.
Uterine Contractile Responses to Endothelin-1 and Endothelin Receptors Are Elevated during Labor1 (1994)

The purpose of this study was to determine whether the contractile responsiveness of the rat uterus to endothelin (ET)-1 and myometrial ET-1 receptors is elevated during labor. Uterine contractile responses to ET-1 were measured in isolated uterine strips obtained from rats on Day 18 of gestation, during spontaneous labor at term, and on Days 1 and 2 postpartum. The mean force (millinewtons) generated by cumulative addition of ET-1 (10(-10)-10(-6) M) was measured in vitro. Cumulative dose-response curves were created based upon the contractile activity vs. log doses of ET-1. The values of the estimated pD2, Emax, and slope of the dose-response curves were significantly (p < 0.05) higher in tissues taken during delivery than in tissues from animals on Day 18 of gestation or Days 1 and 2 postpartum. Myometrial ET-1 receptors were also measured during pregnancy and labor. Scatchard analysis of the ET-1 binding to myometrial membranes revealed that receptor levels were significantly (p < 0.05) elevated in delivering animals, without changes in their affinity. Our study shows that the uterus is more sensitive and responsive to the contractile effects of ET-1 during labor, at term, when the receptor density is increased. The change in ET-1 responsiveness at term may play a role in the initiation and/or progression of labor.
Trust Computing for Social Networking (2009)

Trust plays an important role in a Web-based social network. Given the open and dynamic nature of such an online virtual community, trust evaluation relies on transitive relationships among the direct and indirect neighbors of an evaluator. We propose a framework to evaluate the trustworthiness of a given node (e.g., a user) based on a set of trust chains and a trust graph. We will also systematically analyze the inherent relationships between the two approaches. Many terms presented in this paper are new, including a virtual trust chain, the capacity, completeness, and degree of a trust graph, and a base trust chain set for a complete trust graph. Our contributions also include algorithms outlining novel approaches for peer trust evaluation in social networks.
NMDA Receptors and Huntington’s Disease (2008)

Ample evidence suggests a critical role for NMDARs in initiating MSN dysfunction and death in HD. The expression of mhtt may produce changes in NMDAR composition, trafficking, and function. Additionally, it may affect neuronal responses to NMDAR activation, particularly those downstream of and dependent upon Ca2+ signalling and mitochondrial pathways (Figure 2.1). Evidence from cellular and animal models of HD suggests that these changes in turn can alter synaptic function and enhance the susceptibility of MSNs to NMDAR-mediated excitotoxicity in a polyQ length-dependent fashion. In summary, NMDARs may play a prominent role in the pathology of HD. The complexity of the interactions between mhtt and NMDARs presents a number of possible targets for effective and selective therapies.
The effect of electronic dental anesthesia on behavior during local anesthetic injection in the young, sedated dental patient. (1999)

The EDA appears to be beneficial in reducing the discomfort, as judged by behavioral and physiologic observations, associated with local anesthetic administration in young sedated dental patients.
Electron optical properties and aberrations of a miniaturized electron beam system (1992)

Based on dimensional analysis, a configuration of a microlens system for focusing an electron beam can be obtained by the dimensional scaling down from a conventional lens. An electrostatic microlens system consisting of two planar microsize apertures has been investigated. For this microlens, the spherical and chromatical aberrations, the astigmatism due to elliptic distortion, and the displacement due to misalignment have been calculated in detail. The resolution has been derived by a general formula, and thus has been evaluated numerically. The computational results have shown that the miniaturized microlens system proposed in the present article possesses remarkably small aberrations and ultrahigh resolution in the low voltage operation, and will be likely applicable for some practical uses.
Footstep recognition for a smart home environment (2008)

This paper reports some experiments which assess the potential use of a footstep biometric verification system for a smart home environment. We present a semi-automatic capture system and report results on a database with independent development and evaluation datasets comprised of more than 3500 footsteps collected from 55 persons. We present an optimisation of geometric and holistic feature extraction approaches. An equal error rate of 13 % is obtained with holistic features classified with a support vector machine. The database is freely available to the research community. 1.
The significance of Sense of Coherence in health care staff's experiences of reorganisations (2009)

The significance of Sense of Coherence in health care staff's experiences of reorganisations
Osteoarthritis and its association with muscle hyperalgesia: an experimental controlled study (2001)

Hypertonic saline effectively excites muscle nociceptors. Muscle hyperalgesia was assessed in osteoarthritis (OA) by intramuscular infusion of 0.5 ml hypertonic saline (6%) into the tibialis anterior muscle in humans. Patients (n=14) with OA in the lower extremities were compared with an equal number of age- and sex-matched healthy controls. Ten of the 14 OA patients had pain in the knee joint as the most common presenting complaint. Visual analogue scale (VAS) pain intensity and assessment of pain areas were recorded before infusion and immediately, 2, 5, 10 and 20 min after infusion, and then every 10 min, until the pain vanished. The mean pain offset time in OA patients (11.3+/-7.9 min) was larger as compared with the control subjects (6.04+/-2.1 min) (P=0.025). OA patients had increased pain intensity VAS after the infusion in the right leg compared with controls (P<0.05). Referred and radiating pain areas at 2 min post-infusion increased in OA patients and not in controls as compared with the local pain areas (P<0.05). It is concluded that muscle hyperalgesia and extended pain areas might be due to central sensitization caused by painful osteoarthritis.
Macrophage lipoprotein lipase promotes foam cell formation and atherosclerosis in vivo (1999)

Expression of lipoprotein lipase (LPL) by the macrophage has been proposed to promote foam cell formation and atherosclerosis, primarily on the basis of in vitro studies. LPL-deficient mice might provide a model for testing the role of LPL secretion by the macrophage in an in vivo system. Unfortunately, homozygous deficiency of LPL in the mouse is lethal shortly after birth. Because the fetal liver is the major site of hematopoiesis in the developing fetus, transplantation of C57BL/6 mice with LPL-/- fetal liver cells (FLCs) was used to investigate the physiologic role of macrophage LPL expression in vivo. Thirty-four female C57BL/6 mice were lethally irradiated and reconstituted with FLCs from day 14 LPL+/+, LPL+/-, and LPL-/- donors. No significant differences were detected in plasma levels of post-heparin LPL activity or in serum cholesterol or triglyceride levels between the 3 groups on either a chow diet or an atherogenic diet. After 19 weeks on the atherogenic diet, aortae were collected for quantitative analysis of the extent of aortic atherosclerosis. LPL expression was detected by immunocytochemistry and in situ hybridization in macrophages of aortic atherosclerotic lesions of LPL+/+-->C57BL/6 and LPL+/--->C57BL/6 mice, but not in LPL-/--->C57BL/6 mice, whereas myocardial cells expressed LPL in all groups. The mean aortic lesion area was reduced by 55% in LPL-/--->C57BL/6 mice compared with LPL+/+-->C57BL/6 mice and by 45% compared with LPL+/--->C57BL/6 mice, respectively. These data demonstrate in vivo that LPL expression by macrophages in the artery wall promotes foam cell formation and atherosclerosis. off
An Amplification-Promoting Sequence from Mouse Genomic DNA: Interaction with a <i>Trans</i> -Acting Factor That Also Affects Gene Expression (1990)

We previously identified murine DNA sequences that stimulate the amplification of cis-linked plasmid DNA in mouse cells under selective conditions (Holst et al., 1988). Here we focus on the structural features of one of these elements, the 229-bp element 5. The amplification-promoting activity was fully recovered from the middle part of element 5. The active region interacted in a sequence-specific way with a protein from nuclear extracts. Using footprinting analyses the binding region was characterized and subsequently shown to be functionally active as an amplification-promoting sequence, whereas a mutated binding site was inactive. Therefore, cis-acting element 5 functioned via interaction with a trans-acting factor. The same binding site was also active as a promoter element for RNA polymerase II transcription, because it efficiently reconstituted the activity of a truncated herpes simplex virus type 1 (HSV-1) thymidine kinase (tk) gene promoter lacking the distal Sp1 binding site. Thus, the same protein seems to function in both RNA polymerase II transcription and DNA amplification. Possible relationships between both functions are discussed.
<title>General machining concept for producing micro-optics with high-power UV lasers</title> (1997)

The development of new processes for the micro-treatment of material is the basis for increasing integration and miniaturization of mechanical, optical and electronic components. Pulsed high power excimer lasers offer in combination with a micro-machining system, the possibility of manufacturing highly complex components in different materials like ceramics, glass or metals, Because of the increasing number of technical applications, the need for automatic processing has grown in the last few years. While complete working stations are available for Nd:YAG and CO<SUB>2</SUB> lasers, there is a lack for automatic micro-removal with excimer lasers. For complex microstructures like micro- optics, manual programming of the workpiece handling system becomes uneconomic because of the very high number of laser pulses required. Especially for prototypes and small batches where the workpiece geometries change quickly, the development of a universal and automatic machining concept plays a key role for this technology. For this reason, a general machining concept based on excimer laser removal has been realized beginning with the possibility to construct the workpiece geometry by CAD-design tools. A preprocessor allows to calculate the removal volume based on laser specific ablation volumes. The superposition of each laser pulse removal leads to complex 3D surface structures. Moreover, a general movement strategy optimizes the processing speed. For closing the process chain the realized preprocessor automatically generates the necessary NC-data for the implemented CNC-control system. Functionality of this concept has been proven by manufacturing different two and three dimensional micro-structures like micro-optical components.
PURINES V. THE PREPARATION OF CERTAIN 2,9-SUBSTITUTED PURINES AND AZAPURINES<sup>1</sup> (1955)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPURINES V. THE PREPARATION OF CERTAIN 2,9-SUBSTITUTED PURINES AND AZAPURINES1K. L. DILLE, M. L. SUTHERLAND, and B. E. CHRISTENSENCite this: J. Org. Chem. 1955, 20, 2, 171–177Publication Date (Print):February 1, 1955Publication History Published online1 May 2002Published inissue 1 February 1955https://pubs.acs.org/doi/10.1021/jo01120a003https://doi.org/10.1021/jo01120a003research-articleACS PublicationsRequest reuse permissionsArticle Views131Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts