gebhart/patrepeval huggingface dataset:
[Treatment for cyanide compound in waste fluid containing cyanmethemoglobin with ultraviolet radiation. 1. Use of hydrogen peroxide jointly at the same time (author's transl)]. (1978)

One of the major issues during soft lithographic processes is that, if the pressing force on the stampbecomes too high, the stamp may erroneously come into contact with the substrate in zones where contact is not intended. This decreases the patterning accuracy and may lead to badly or nonperforming electronicdevices and is therefore undesired. Design rules, available at an early stage in the design phase, are desired to speed-up the development of this technique. Ultimately, these rules should give an indication of the critical pressure that can safely be applied on the stamp thereby avoiding unwanted contact between thestamp and the substrate. To obtain these critical pressures, numerical analyses of the deformation behavior of two characteristic configurations in the microstructured surface pattern of the rubber stamp are performed. The deformation behavior of the rubber is modeled according to a Gaussian and a non-Gaussian approach, leading to a neo-Hookean and Arruda-Boyce constitutive model, respectively. Besides these material nonlinearities, geometrical nonlinearities are taken into account as well. The calculated pressure at which undesired contact takes place (the roof collapse pressure) is compared to experimentally obtained values for two particular types of structures, and the results are in agreement within the error margins of the experiments and those ensuing from the assumptions of the numerical simulations.
m3D: A multidimensional dynamic configurable router (2002)

m3D is the third attempt to produce a dynamically configurable, multilayer router which not only can handle traditional two-level routing problems, but also multilayer routing and three-dimensional routing. The basic maze algorithm is extended so that all points connected to the net under consideration are used to propagate the cost wave. This results in the next shortest link between all the subnetwork components to be found, and a dynamically determined minimum spanning tree to be constructed for each network. Several levels of modifications are conducted on the preexisting routes, along with a rip-up and reroute strategy to handle the more dense problems. Test results indicate that m3D can complete problems as well as, or better than, many of the well-known routers, and that it has the capability of handling a wide range of routing problems. The router is part of an integrated automatic cell layout generation system.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Beyond eureka moments: Supporting the invisible work of creativity and innovation (2011)

Introduction. This paper is about the challenges of working creatively and reflectively in the information-intensive environments characteristic of our digital age. Method. The paper builds upon earlier work about uncertainty in library and information science by incorporating work exploring risk cultures and uncertainty as everyday phenomena. It presents arguments emerging from an ongoing investigation of the background work involved in scholarly research practice. These threads are used to invite discussion about the particular strategic contribution that the ISIC community might make in answer to calls for more creativity and greater support for the human spirit in all that we do. Analysis. Ethnographic material about scholarly research practice is combined with varied research exploring creativity and uncertainty. Results. Analysis of conditions that can stimulate creativity suggests that working through and being in uncertainty provides a site of creativity stimulation that addresses Howkins's query about how and where we wish to do our thinking. Conclusions. As information researchers and practitioners, we can act as stewards within our communities and help shape the information services and infrastructures that support organisations and communities striving to be more creative and to engage with information in inventive ways. Doing so will require us to not only support the creativity and innovation of others, but to be creative and innovative ourselves. © the author 2011.
Impact of Pretransplantation Minimal Residual Disease, As Detected by Multiparametric Flow Cytometry, on Outcome of Myeloablative Hematopoietic Cell Transplantation for Acute Myeloid Leukemia (2011)

Purpose Allogeneic hematopoietic cell transplantation (HCT) benefits many patients with acute myeloid leukemia (AML) in first remission. Hitherto, little attention has been given to the prognostic impact of pretransplantation minimal residual disease (MRD). Patients and Methods We retrospectively studied 99 consecutive patients receiving myeloablative HCT for AML in first morphologic remission. Ten-color multiparametric flow cytometry (MFC) was performed on bone marrow aspirates before HCT. MRD was identified as a cell population showing deviation from normal antigen expression patterns compared with normal or regenerating marrow. Any level of residual disease was considered MRD positive. Results Before HCT, 88 patients met morphologic criteria for complete remission (CR), whereas 11 had CR with incomplete blood count recovery (CRi). Twenty-four had MRD before HCT as determined by MFC. Two-year estimates of overall survival were 30.2% (range, 13.1% to 49.3%) and 76.6% (range, 64.4% to 85.1%) for MRD-positive and MRD-negative patients; 2-year estimates of relapse were 64.9% (range, 42.0% to 80.6%) and 17.6% (range, 9.5% to 27.9%). After adjustment for all or a subset of cytogenetic risk, secondary disease, incomplete blood count recovery, and abnormal karyotype pre-HCT, MRD-positive HCT was associated with increased overall mortality (hazard ratio [HR], 4.05; 95% CI, 1.90 to 8.62; P < .001) and relapse (HR, 8.49; 95% CI, 3.67 to 19.65; P < .001) relative to MRD-negative HCT. Conclusion These data suggest that pre-HCT MRD is associated with increased risk of relapse and death after myeloablative HCT for AML in first morphologic CR, even after controlling for other risk factors.
Task Synthesis for Control Applications on Multicore Platforms (2014)

Multicore processors promise to improve the performance of systems, by integrating more and more cores onto a single chip. Existing software systems, such as control software from the automation domain, need adjustments to be adapted on multicores. To exploit the concurrency offered by multicore processors, appropriate algorithms have to be used to divide the control application software into tasks, and tailored task partitioning and scheduling approaches are required to increase the overall performance. In this paper we present a model-driven approach for automatic synthesis and deployment of control applications on multicore processors. The approach is centered around a system model, which describes the control applications, the multicore platform, as well as the mapping between the two. We apply the approach on a number of control applications out of which we synthesize tasks and present their run-time behavior in a real-time operating system.
Uncalibrated stereo rectification for automatic 3d surveillance (2005)

We describe a stereo rectification method suitable for automatic 3D surveillance. We take advantage of the fact that in a typical urban scene, there is ordinarily a small number of dominant planes. Given two views of the scene, we align a dominant plane in one view with the other. Conjugate epipolar lines between the reference view and plane-aligned image become geometrically identical and can be added to the rectified image pair line by line. Selecting conjugate epipolar lines to cover the whole image is simplified since they are geometrically identical. In addition, the polarities of conjugate epipolar lines are automatically preserved by plane alignment, which simplifies stereo matching.
A New Pilot-Aided Integer Frequency Offset Estimation Method for Digital Video Broadcasting (DVB) Systems (2008)

In this paper, a new integer frequency offset estimation method is proposed for orthogonal frequency division multiplexing (OFDM)-based digital video broadcasting (DVB) systems. Several pilot-aided frequency offset estimation methods have been proposed for OFDM-based DVB systems. In the conventional methods, however, the information of some combinations that pilots provide is used only. Thus, in this paper, we propose a new integer frequency offset estimation method exploiting the information of all combinations that pilots provide. The simulation results show that the proposed method outperforms the conventional method in terms of the probability of integer frequency offset estimation failure.
The Influence of Various Amphiphilic Phosphates on in vitro Caries Lesion Formation in Human Dental Enamel (1992)

Some newly designed surface-active phosphates were investigated with respect to their capacity to inhibit caries lesion formation in vitro. On the labial or buccal surfaces of sound human third molars, windows were prepared for investigation. One half of each window was treated with the test compound at pH values of 7.5, 5.5, or 3.5. The other half served as a control. Both halves were demineralized and the generated caries lesions in both parts were compared by means of quantitative microradiography. Mono-, bis- and trisphosphates differed only marginally in their effect on the demineralization. The compounds diminished the demineralization down to 30% of that of untreated enamel. Per molecule at least one long alkyl chain (more than 12 C atoms) was required for achieving decreased demineralization, indicating the importance of a low surface tension. The results suggest that some of the tested compounds have promising properties for their use as anticaries agents, especially when applied in combination with fluoride.
Antioxidant Potential of Dimethyl Lithospermate Isolated from <i>Salvia miltiorrhiza</i> (Red Sage) Against Peroxynitrite (2008)

Peroxynitrite (ONOO(-)) is a reactive oxidant formed from superoxide and nitric oxide that can readily oxidize cellular components, including essential protein, non-protein thiols, and DNA. ONOO(-) has contributed to the pathogenesis of diseases such as stroke, heart disease, Alzheimer's disease, and atherosclerosis. In this study, the ability of dimethyl lithospermate (DML), isolated from Salvia miltiorrhiza, to scavenge ONOO(-) and to protect cells against reactive species and ONOO(-) was investigated. The data obtained show that DML can efficiently scavenge native ONOO(-) as well as ONOO(-) derived from the ONOO(-) donor 3-morpholinosydnonimine hydrochloride. Spectrophotometric analysis revealed that DML led to decreased ONOO(-)-mediated nitration of tyrosine through electron donation. DML significantly inhibited nitration of bovine serum albumin by ONOO(-) in a dose-dependent manner. DML also manifested cytoprotection from cell damage induced by ONOO(-). The present study suggests that DML is an effective ONOO(-) scavenger and promotes cellular defense activity in the protection against ONOO(-)-involved diseases.
Interactive wavelet processing and techniques applied to digital mammography (2002)

We present an interactive scheme for processing of digital mammograms relying upon a steerable dyadic wavelet transform. Coefficients of the translation and rotation-invariant transform are interactively processed before an inverse transform is applied. Analysis is carried out at dyadic scales and along arbitrary orientations. Local orientation is computed at each level of scale and spatial position and formulated into criteria for including or excluding specific orientations for contrast enhancement and enhancing locally radiating structures. Transform coefficients that were selected for contrast enhancement are modified by a piecewise linear enhancement function. The presented scheme is flexible enough to enable efficient position, scale, and orientation based interactive processing and analysis.
Budesonide and terbutaline or terbutaline alone in children with mild asthma: effects on bronchial hyperresponsiveness and diurnal variation in peak flow. (1991)

The effects of treatment with budesonide (200 micrograms twice daily) and terbutaline (500 micrograms four times daily) has been compared with the effects of placebo and terbutaline in 27 children with mild asthma, aged 7-14 years, in a double blind, randomised placebo controlled study over eight weeks. Bronchial responsiveness (PC20 histamine), lung function, the amplitude of diurnal variation in peak expiratory flow (PEF), and symptom scores were measured. Baseline FEV1 was over 70% predicted and PC20 histamine less than 8 mg/ml. Twelve children were treated with budesonide and terbutaline and 15 with placebo and terbutaline. After four and eight weeks of treatment the change in PC20 was significantly greater after budesonide and terbutaline than after terbutaline alone by 2.1 (95% CI 0.5-3.8) and 1.3 (95% CI 0.1-2.5) doubling doses respectively. Mean FEV1 did not change in either group. The change in afternoon and nocturnal PEF was significantly greater after budesonide and terbutaline than after terbutaline alone. The amplitude of diurnal variation in PEF did not change significantly in either group. Peak flow reversibility decreased in the budesonide group. There were no differences between treatments for cough and dyspnoea, but wheeze improved in the budesonide group. The children with mild asthma treated with budesonide and terbutaline showed improvement in bronchial responsiveness, afternoon and nocturnal PEF, and symptoms of wheeze and a fall in peak flow reversibility by comparison with those who received terbutaline alone.
Meisoindigo is a promising agent with<i>in vitro</i>and<i>in vivo</i>activity against human acute myeloid leukemia (2010)

Meisoindigo, a derivative of Indigo naturalis, has been used in China for chronic myeloid leukemia. In vitro cell line studies have shown that this agent might induce apoptosis and myeloid differentiation of acute myeloid leukemia (AML). In this study, we explored its mechanisms and potential in AML. NB4, HL-60, and U937 cells and primary AML cells were used to examine its effects and the NOD/SCID animal model was used to evaluate its in vivo activity. Meisoindigo inhibited the growth of leukemic cells by inducing marked apoptosis and moderate cell-cycle arrest at the G(0)/G(1) phase. It down-regulated anti-apoptotic Bcl-2, and up-regulated pro-apoptotic Bak and Bax and cell-cycle related proteins, p21and p27. Furthermore, it induced myeloid differentiation, as demonstrated by morphologic changes, up-regulation of CD11b, and increased nitroblue tetrazolium reduction activity in all cell lines tested. In addition, meisoindigo down-regulated the expression of human telomerase reverse transcriptase and enhanced the cytotoxicity of conventional chemotherapeutic agents, cytarabine and idarubicin. As with the results from cell lines, meisoindigo also induced apoptosis, up-regulated p21 and p27, and down-regulated Bcl-2 in primary AML cells. The in vivo anti-leukemic activity of meisoindigo was also demonstrated by decreased spleen size in a dose-dependent manner. Taking these results together, meisoindigo is a potential agent for AML.
ALLOSTERIC MODULATION OF BENZODIAZEPINE GABA-RECEPTOR-IONOPHORE COMPLEX BY NONBENZODIAZEPINES (1984)

Department of Pharmacology, The University of Texas, Health Science Center at San Antonio, Texas 78284, U.S.A.
Effects of earlens lens placement on sound field thresholds, tympanometric measurements and wideband acoustic immittance (2022)

Lens wear had a small effect on audiometric thresholds and tympanometry for most patients. Clinicians who use compliance and power absorbance should take into consideration lens effects on these measurements. Additional work is required to develop clinical normative ranges of these measures for wearers of the Earlens.
A state selection algorithm for the automated state model generator (1999)

A powerful technique for the modeling and analysis of lumped-parameter power-electronic-based systems with changing topology has been previously developed. In this modeling approach, the state space representation of the overall system is generated automatically and updated dynamically based upon the topological state of the system. Although this method has been applied successfully to numerous power converter circuits, it fails to produce a state model for circuit topologies that include capacitive loops. In this thesis, a generalized state model generation algorithm is set forth that is applicable for all practically useful topologies of power electronic systems. In this method, a composite electrical network is viewed as inductive, capacitive, and algebraic subnetworks interconnected with each other. Decomposition of the global system into three elementary networks enables the identification of minimal sets of natural state variables; currents (fluxes) and voltages (charges), for the inductive and capacitive subsystems, respectively. A deterministic and robust state selection algorithm based on the theory of weighted graphs has been developed to enable network partitioning. The algorithm can also be used to ensure continuity of the state variables across topological boundaries. The network identification procedure for partitioning the global system has also been extended to a more general case of multiple networks. The algorithmically-generated state equations have a well-defined structure that is convenient for efficient computer implementation and modeling of networks with different types of parameters (constant, time-varying, linear, nonlinear, etc.) and switching characteristics.
<i>Current Review</i>Phenolic Compounds as Regulators of Gene Expression in Plant-Microbe Interactions (1990)

Article synthese sur l'activite biologique des composes phenoliques synthetises par la plante et sur la transduction du signal au niveau du microorganisme qui interagit avec la plante. Ces composes phenoliques semblent reguler l'expression genique des genes de l'agent en relation avec la plante
Exploring Campylobacter seasonality across Europe using The European Surveillance System (TESSy), 2008 to 2016 (2019)

BackgroundCampylobacteriosis is the most commonly reported food-borne infection in the European Union, with an annual number of cases estimated at around 9 million. In many countries, campylobacteriosis has a striking seasonal peak during early/mid-summer. In the early 2000s, several publications reported on campylobacteriosis seasonality across Europe and associations with temperature and precipitation. Subsequently, many European countries have introduced new measures against this food-borne disease.AimTo examine how the seasonality of campylobacteriosis varied across Europe from 2008-16, to explore associations with temperature and precipitation, and to compare these results with previous studies. We also sought to assess the utility of the European Surveillance System TESSy for cross-European seasonal analysis of campylobacteriosis.MethodsWard's Minimum Variance Clustering was used to group countries with similar seasonal patterns of campylobacteriosis. A two-stage multivariate meta-analysis methodology was used to explore associations with temperature and precipitation.ResultsNordic countries had a pronounced seasonal campylobacteriosis peak in mid- to late summer (weeks 29-32), while most other European countries had a less pronounced peak earlier in the year. The United Kingdom, Ireland, Hungary and Slovakia had a slightly earlier peak (week 24). Campylobacteriosis cases were positively associated with temperature and, to a lesser degree, precipitation.ConclusionAcross Europe, the strength and timing of campylobacteriosis peaks have remained similar to those observed previously. In addition, TESSy is a useful resource for cross-European seasonal analysis of infectious diseases such as campylobacteriosis, but its utility depends upon each country's reporting infrastructure.
Methionine depletion modulates the antitumor and antimetastatic efficacy of ethionine. (1996)

The elevated methionine requirement for the growth of tumors, termed methionine dependence, is a potentially highly effective therapeutic target. To attack this target we are developing anti-methionine chemotherapy. In this study of anti-methionine chemotherapy we have observed that the methionine analog ethionine is synergistic with methionine depletion in arresting the growth of the Yoshida sarcoma both in vitro and when transplanted to nude mice. In contrast, ethionine in vitro in a methionine-containing medium is not effective against Yoshida sarcoma cells. Similarly, ethionine administered along with a methionine-containing diet is ineffective against the Yoshida sarcoma growing in nude mice. A methionine-depleted diet alone is only partially effective against tumor growth. The Yoshida sarcoma gave rise to metastases in 75% of the- organs observed in the mice on the methionine-containing diet, and 43 % of the organs in the mice on the methionine-free diet. In striking contrast, no metastases were observed in the ethionine-treated animals on the methionine-free diet. Anti-methionine chemotherapy consisting of dietary methionine depletion and ethionine administration caused an initial weight loss but the animals weight stabilized resulting in no animal deaths. The synergism of ethionine and methionine depletion is markedly similar in vitro and in vivo suggesting the observed efficacy is due to the specific anti-methionine targeting. Thus methionine depletion highly potentiates the anti-tumor and anti-metastatic effectiveness of ethionine suggesting that anti-methionine chemotherapy consisting of methionine depletion as a modulator of methionine analogs holds great promise as a new, tumor-selective therapeutic approach.
A scalable readout system for a superconducting adiabatic quantum optimization system (2010)

We have designed, fabricated and tested an XY-addressable readout system that is specifically tailored for the reading of superconducting flux qubits in an integrated circuit that could enable adiabatic quantum optimization. In such a system, the flux qubits only need to be read at the end of an adiabatic evolution when quantum mechanical tunneling has been suppressed, thus simplifying many aspects of the readout process. The readout architecture for an $N$-qubit adiabatic quantum optimization system comprises $N$ hysteretic dc SQUIDs and $N$ rf SQUID latches controlled by $2\sqrt{N} + 2$ bias lines. The latching elements are coupled to the qubits and the dc SQUIDs are then coupled to the latching elements. This readout scheme provides two key advantages: First, the latching elements provide exceptional flux sensitivity that significantly exceeds what may be achieved by directly coupling the flux qubits to the dc SQUIDs using a practical mutual inductance. Second, the states of the latching elements are robust against the influence of ac currents generated by the switching of the hysteretic dc SQUIDs, thus allowing one to interrogate the latching elements repeatedly so as to mitigate the effects of stochastic switching of the dc SQUIDs. We demonstrate that it is possible to achieve single qubit read error rates of $<10^{-6}$ with this readout scheme. We have characterized the system-level performance of a 128-qubit readout system and have measured a readout error probability of $8\times10^{-5}$ in the presence of optimal latching element bias conditions.