gebhart/patrepeval huggingface dataset:
Cerium Ion Mobility and Diffusivity Rates in Perfluorosulfonic Acid Membranes Measured via Hydrogen Pump Operation (2017)

Ion mobility and diffusivity coefficients were determined for cerium ions in Nafion XL perfluorosulfonic acid ionomer membranes at 100% and 50% relative humidity in a conductivity cell using a hydrogen pump. We quantified Ce ion migration profiles as a function of charge transfer through the cell using X-ray fluorescence (XRF). To decouple simultaneous effects of Ce ion mobility and back-diffusion which occur due to potential and concentration gradients, respectively, a one-dimensional model was developed and fit to these intermittent XRF profiles. The resulting mobility and diffusivity coefficients demonstrate the dramatic effects of potential and concentration gradients on Ce ion migration during PEM fuel cell operation.
Sensorless Field Oriented Control of Multiple Permanent Magnet Motors (2013)

This application report presents a solution to control multiple permanent magnet synchronous motors (PMSM, BLDC, and so forth ) simultaneously using the TMS320F2803x microcontrollers. Although the motors included in the “Multi Axis +PFC Kit” are brushless dc (BLDC), the same experimental procedure can be applied to various permanent magnet motors. TMS320F2803x devices are part of the family of C2000 microcontrollers, which enables the cost-effective design of intelligent controllers for three phase motors by reducing the system components and increasing efficiency. With these devices, it is possible to realize far more precise digital vector control algorithms like the field orientated control (FOC). The algorithm’s implementation is discussed in this document. The FOC algorithm maintains efficiency in a wide range of speeds and takes into consideration torque changes with transient phases by processing a dynamic model of the motor. Among the solutions proposed are ways to eliminate the phase current sensors and use an observer for speed sensorless control. This application report covers the following: • A theoretical background on field oriented motor control principle • Incremental build levels based on modular software blocks • Experimental results
A QoS-Aware Web Service Replica Selection Framework for an Extranet (2006)

Business partners in an extranet expect Web services to be offered in a timely fashion. Replicating Web services may reduce the end-to-end Web service response time and add fault tolerance to the system. In this paper, we propose a Web service replica selection framework that can be deployed in an extranet. The selection procedure is based on dynamic factors such as communication delays between the Web service provider and the Web service requester and the workload of the Web service provider. To analyze the performance of the framework, two Web service replica selection policies are simulated: minU and random. Simulation results show that the minU policy has better response time especially under high load conditions
Children's Understanding: The Development of Mental Models (1993)

This work argues that cognitive development is experience driven, and processes entailed in acquiring information about the world are analyzed based on recent models of learning and induction. The way information is represented and accessed when performing cognitive tasks is considered paying particular attention to the implications of Parallel Distributed Processing (PDP) models for cognitive development. The first half of the book contains analyses of human reasoning processes (drawing on PDP models of analogy), development of strategies, and task complexity -- all based on aspects of PDP representations. It is proposed that PDP representations become more differentiated with age, so more vectors can be processed in parallel, with the result that structures of greater complexity can be processed. This model gives an account of previously unexplained difficulties in children's reasoning, including some which were influential in stage theories. The second half of the book examines processes entailed in some representative cognitive developmental tasks, including transitive inference, deductive inference (categorical syllogisms), hypothesis testing, learning set acquisition, acquisition and transfer of relational structures, humor, hierarchical classification and inclusion, understanding of quantity, arithmetic word problems, algebra, conservation, mechanics, and the concept of mind. Process accounts of tasks are emphasized, based on applications of recent developments in cognitive science.
RETARDED ABSORPTION OF PELLETS OF PROTAMINE-ZINC INSULIN (1949)

AFTER Parkes and Young (1939(1)), Mark and Biskind (1940(2)), Cutting, Morton and Cohn (1941(3)) and Parkes (1942(4)) proved the inefficacy of subcutaneous implants of insulin, either pure or with cholesterol, this experimental path was apparently abandoned. McCullagh and Lewis (1942(5)) reported prolonged effects with subcutaneous implantations of tablets of insulin-cholesterol in 4 dogs and of silver tubes filled with crystalline insulin and open at one end, in 5 others. All dogs were normal. A definite decrease in the blood sugar was evident for a period of twenty-one days. Potent insulin was found in the removed tissue-encapsulated remnants of the implants. In spite of these discouraging results, we decided in 1943 to carry on the study of insulin implants, a therapeutic method which was giving excellent results with liposoluble hormones in clinical medicine. Our experiments in normal (Vargas, Koref and Zañartu, 1944(6)) and diabetic rabbits (Vargas, Koref and Lewin, 1948(7)) implanted with a protamine-zinc-insulin complex resulted so satisfactorily that one of us has been able to apply it in clinical practice (Vargas and Lewin, 1948(8) and Vargas, 1949(9)).
In vivo endoscopic mass spectrometry using a moving string sampling probe (2017)

At present, endoscopy relies almost exclusively on optical microscopy and the accurate analysis such as MS interrogation is performed ex situ using biopsy. In this work, a novel probing system is developed to perform in situ and in vivo endoscopic mass spectrometry using a moving string for the sampling and transportation of material. A prototype of a mass spectrometric endoscope is constructed using an industrial endoscope and a commercial mass spectrometer. The sampling system consists of a moving cotton thread driven by motorized pulleys. When the target surface is touched by the sampling probe, the cotton thread "wipes" and transports the adhered sample to the ion source. Depending on the target analytes, desorption electrospray and atmospheric pressure chemical ionization sources are employed interchangeably for the desorption and ionization. The surface under analysis is not subjected to heat, organic solvents, high voltage or charged droplets. In situ endoscopic MS of a living mouse and surface analysis inside a volunteer subject's mouth are demonstrated.
Sulfatide-dependent autoactivation of human blood coagulation Factor XII (Hageman Factor). (1983)

When purified human blood coagulation Factor XII (Hageman factor) is incubated with sulfatides at 37 degrees C, activation of Factor XII occurs as judged by the appearance of amidolytic activity towards the chromogenic substrate H-D-Pro-Phe-Arg-p-nitroanilide. Polyacrylamide gel electrophoresis studies using 125I-Factor XII as a marker show that the appearance of amidolytic activity correlates with Factor XII cleavage, that activation goes to completion and that virtually all Factor XIIa formed is present as the two-chain, 80,000 Mr form, alpha-Factor XIIa. Rigorous analysis of kinetic data establishes that, between 0.02 and greater than 90% of the reaction, the activation of Factor XII is described by a mechanism of autoactivation of Factor XII by Factor XIIa. The rate of autoactivation increases with increasing Factor XII concentrations at constant sulfatide levels but decreases with increasing sulfatide concentrations at constant levels of Factor XII. These findings suggest that the concentrations of Factor XII and Factor XIIa bound to the sulfatide surface determine the rate of autoactivation. Soybean trypsin inhibitor, Trasylol, and anti-prekallikrein antibodies have no influence on the rate of sulfatide-dependent autoactivation of Factor XII. Benzamidine inhibits autoactivation with an inhibitor constant, Ki, of 1.9 mM which is similar to the Ki of 1.5 mM for the enzyme, alpha-Factor XIIa. Thus, sulfatide-dependent activation of purified Factor XII is not due to contaminating proteases and is described by a second order mechanism of autoactivation due to the action of surface-bound Factor XIIa on surface-bound Factor XII.
Oral Hypoglycemic Drugs for Gestational Diabetes (2000)

Gestational diabetes mellitus has been a contentious subject since it was first described. From a global perspective, authors have questioned its very existence, the burden of morbidity that it causes, and whether making the diagnosis simply increases the expense and complexity of perinatal care. Arguments have raged over who should be tested for gestational diabetes, when during pregnancy the testing should be done, what results define the disorder, and how affected women should be treated. For those willing to acknowledge that moderate abnormalities in carbohydrate metabolism during pregnancy require attention, there has been one point of agreement: if diet and . . .
The TNF-α/ROS/HIF-1-induced Upregulation of FoxMI Expression Promotes HCC Proliferation and Resistance to Apoptosis (2012)

The proliferation-specific transcription factor Forkhead box M1 (FoxM1) acts as a master regulator of cancer cell growth and survival and plays an important role in the development of hepatocellular carcinoma. However, the molecular mechanisms that regulate FoxM1 expression remain largely unknown. In the current study, we demonstrated that tumor necrosis factor (TNF)-αα induced FoxM1 expression and transactivated its promoter activity in hepatoma cells. Serial 5" deletion and site-directed mutagenesis revealed that the induction of FoxM1 expression by TNF-α was dependent upon the hypoxia-inducible factor 1 (HIF1)-1 and HIF1-3/4 binding sites within the FoxM1 promoter. Furthermore, at the transcriptional level, the stabilization of HIF-1α via reactive oxygen species generation led to the binding of HIF-1α to the FoxM1 promoter and resulted in increased FoxM1 expression. The inhibition of both HIF-1α expression and reactive oxygen species generation significantly decreased TNF-α-induced FoxM1 overexpression. Consequently, the upregulation of FoxM1 promoted the proliferation of hepatoma cells and enhanced their resistance to TNF-α-induced apoptosis. Consistently, there was a positive correlation between HIF-1α and FoxM1 expression in 406 human hepatocellular carcinoma tissues, and the combination of these two parameters was a powerful predictor of poor prognosis in hepatocellular carcinoma patients after curative resection. Here, we report a new molecular mechanism by which FoxM1 expression is regulated by the TNF-α/reactive oxygen species/HIF-1 pathway, and this mechanism results in the proliferation of hepatoma cells and their resistance to apoptosis.
Lymphoid Precursors in Intestinal Cryptopatches Express CCR6 and Undergo Dysregulated Development in the Absence of CCR6 (2003)

Small intestinal cryptopatches (CP) are the major anatomic site for extrathymic differentiation by precursors destined to become intestinal intraepithelial T lymphocytes (IEL). We found that mice deficient in CCR6 exhibited a 2.7-fold increase in the number of alphabeta TCR IEL, but little or no expansion of gammadelta TCR IEL. Among the alphabeta TCR IEL subsets, the CD4- CD8alphaalpha+ and CD4+ CD8alphaalpha+ subsets were preferentially expanded in CCR6 null mice. Because some CD8alphaalpha+ IEL can arise through extrathymic differentiation in CP, we investigated CCR6 expression by T lymphocyte precursors undergoing extrathymic differentiation in intestinal CP. In sections of CP, 50-60% of c-kit+ precursors were CCR6+. CD11c(+) cells concentrated at the periphery of CP did not express CCR6. A subset of c-kit+, Lin- cells in lamina propria suspensions was CCR6+, but CCR6 was absent from c-kit+ precursors in bone marrow. CCR6 was absent from the vast majority of mature IEL. CCR6 is present on lymphocyte precursors in cryptopatches, expressed transiently during extrathymic IEL development, and is required for homeostatic regulation of intestinal IEL.
Fabrication of double-gated Si field emitter arrays for focused electron beam generation (1995)

Double-gated Si field emitter arrays (FEAs) capable of generating focused electron beams were fabricated and experimentally evaluated. The present field emitter array has a vertical triode structure consisting of a conical Si tip and two gate openings (upper and lower) surrounding the tip. The lower gate with a 2-μm-diam opening acts as an extraction electrode controlling the emission current, and the upper one with a 3-μm-diam opening acts as an electrostatic lens focusing the electron trajectories. The focusing property was evaluated by observing the spot size of a phosphor (ZnO:Zn) screen located about 20 mm apart from the field emitter array and biased to 1 kV. It was found from experimental results that decreasing the upper gate voltage (VF) down to a few volts was quite effective to generate focused electron beams. At VF of about 4 V, the electrons emitted from the tip were well collimated and a beam current of about 0.1 nA/tip was obtained.
Wide supercooled liquid region and soft magnetic properties of Fe56Co7Ni7Zr0–10Nb (or Ta)0–10B20 amorphous alloys (1998)

An amorphous phase with a wide supercooled liquid region before crystallization was formed in Fe56Co7Ni7Zr10−xMxB20 (M=Nb or Ta, x=0–10 at. %) alloys by melt spinning. The glass transition temperature (Tg) and crystallization temperature (Tx) increase by the dissolution of 2% M and the degree of the increase is larger for Tx, leading to maximum ΔTx(=Tx−Tg) of 85 K at 2% Nb and 87 K at 2% Ta which are larger by about 20 K than the largest value for newly developed Fe–(Al, Ga)–(P,C,B,Si) amorphous alloys. The crystallization of the Nb-containing alloys occurs through two stages of amorphous (Am)→Am′+α-Fe+γ-Fe+Fe76Nb6B18 →α-Fe+γ-Fe+Fe76Nb6B18+Fe2Zr in the range less than about 6% Nb and Am→Am′+γ-Fe→γ-Fe+Co3Nb2B5+Ni8Nb in the range above 8% Nb. The change in the crystallization process with Nb content seems to reflect the easy precipitation of γ-Fe by the increase in the number of Fe–Nb pairs with weaker bonding nature as compared with the Fe–Zr pairs. The best soft magnetic properties were obtained at 2% Nb or 8% Ta. The saturation magnetization, coercive force, effective permeability at 1 kHz, and saturated magnetostriction in the annealed state for 300 s at 800 K are, respectively, 0.96 T, 2.0 A/m, 19 100, and 10×10−6 for the 10% Zr alloy, 0.75 T, 1.1 A/m, 25 000, and 12×10−6 for the 2% Nb alloy, and 0.85 T, 1.5 A/m 17 400, and 14×10−6 for the 8% Ta alloy. The Curie temperature is 531 K for the 2% Nb alloy and 538 K for the 8% Ta alloy. The success in synthesizing the new amorphous alloys with the wide supercooled liquid region and good soft magnetic properties is promising for future development as soft magnetic bulk amorphous alloys.
Electrophysiological Evidence of Monosynaptic Excitatory Transmission Between Granule Cells After Seizure-Induced Mossy Fiber Sprouting (2003)

Mossy fiber sprouting is a form of synaptic reorganization in the dentate gyrus that occurs in human temporal lobe epilepsy and animal models of epilepsy. The axons of dentate gyrus granule cells, called mossy fibers, develop collaterals that grow into an abnormal location, the inner third of the dentate gyrus molecular layer. Electron microscopy has shown that sprouted fibers from synapses on both spines and dendritic shafts in the inner molecular layer, which are likely to represent the dendrites of granule cells and inhibitory neurons. One of the controversies about this phenomenon is whether mossy fiber sprouting contributes to seizures by forming novel recurrent excitatory circuits among granule cells. To date, there is a great deal of indirect evidence that suggests this is the case, but there are also counterarguments. The purpose of this study was to determine whether functional monosynaptic connections exist between granule cells after mossy fiber sprouting. Using simultaneous recordings from granule cells, we obtained direct evidence that granule cells in epileptic rats have monosynaptic excitatory connections with other granule cells. Such connections were not obtained when age-matched, saline control rats were examined. The results suggest that indeed mossy fiber sprouting provides a substrate for monosynaptic recurrent excitation among granule cells in the dentate gyrus. Interestingly, the characteristics of the excitatory connections that were found indicate that the pathway is only weakly excitatory. These characteristics may contribute to the empirical observation that the sprouted dentate gyrus does not normally generate epileptiform discharges.
Processing metallic glasses by selective laser melting (2013)

Metallic glasses and their descendants, the so-called bulk metallic glasses (BMGs), can be regarded as frozen liquids with a high resistance to crystallization. The lack of a conventional structure turns them into a material exhibiting near-theoretical strength, low Young's modulus and large elasticity. These unique mechanical properties can be only obtained when the metallic melts are rapidly cooled to bypass the nucleation and growth of crystals. Most of the commonly known and used processing routes, such as casting, melt spinning or gas atomization, have intrinsic limitations regarding the complexity and dimensions of the geometries. Here, it is shown that selective laser melting (SLM), which is usually used to process conventional metallic alloys and polymers, can be applied to implement complex geometries and components from an Fe-base metallic glass. This approach is in principle viable for a large variety of metallic alloys and paves the way for the novel synthesis of materials and the development of parts with advanced functional and structural properties without limitations in size and intricacy.
DeepCut: Joint Subset Partition and Labeling for Multi Person Pose Estimation (2016)

This paper considers the task of articulated human pose estimation of multiple people in real world images. We propose an approach that jointly solves the tasks of detection and pose estimation: it infers the number of persons in a scene, identifies occluded body parts, and disambiguates body parts between people in close proximity of each other. This joint formulation is in contrast to previous strategies, that address the problem by first detecting people and subsequently estimating their body pose. We propose a partitioning and labeling formulation of a set of body-part hypotheses generated with CNN-based part detectors. Our formulation, an instance of an integer linear program, implicitly performs non-maximum suppression on the set of part candidates and groups them to form configurations of body parts respecting geometric and appearance constraints. Experiments on four different datasets demonstrate state-of-the-art results for both single person and multi person pose estimation.
Adapting content for wireless web services (2003)

Motorola Labs' Web-enabled museum system demonstrates how context-aware wireless Web services can adapt their content to a user's dynamic context.
Supramolecular organization of extended benzobisoxazole cruciforms (2010)

Extended benzobisoxazole-based cruciforms, efficiently synthesized using acyl condensations and Sonogashira couplings, form highly ordered two-dimensional sheets in the solid state.
Circulating Levels in Serum of Total Sialic Acid, Lipid-Associated Sialic Acid, and Fucose in Precancerous Lesion and Cancer of the Oral Cavity (1998)

Total sialic acid (TSA), lipid-associated sialic acid (LASA), and fucose were estimated in sera of 35 patients with precancerous lesion of the oral cavity, 68 patients with cancer of the oral cavity, and 25 age- and sex-matched non-chewers of both tobacco and betal nut and nonsmokers as controls. Significant elevation in the serum levels of TSA and LASA were observed in patients with the precancerous and cancer lesions when compared with the controls. Serum TSA levels were elevated significantly in patients with cancer when compared with those with precancerous lesions. Circulating TSA and LASA levels were found to reflect tumor burden and correlated well with stage of the disease. However, serum fucose levels did not show an increase corresponding to stage of the disease. The results suggests that combined evaluation of these markers may be useful in predicting early malignant change and also in assessing the spread and invasiveness of the disease in cancer of the oral cavity.
Organophosphorus compounds. Part V: The resolution of <i>O</i>‐alkyl hydrogen methylphosphonothioates with (+)‐ and (−)‐α‐phenylethylamine (1967)

Abstract A series of four O ‐alkyl hydrogen methylphosphonothioates, (RO)MeP(S)OH, was resolved using both (+)‐ and (−)‐α‐phenylethylamine. Because it gives better results, is rapid and of general applicability the method is to be preferred to that in which alkaloids are used as resolving bases. In one case optical purities of the isolated enantiomers were determined after conversion into acetylcholinesterase inhibitors.
Influence of ePTFE polymer implant permeability on the rate and density of corneal extracellular matrix synthesis (1997)

Microporous polymers have great potential for the production of corneal keratoprosthetic devices. Keratocytes invade the pores of expanded polytetrafluoroethylene implants (ePTFE) and collagen synthesis occurs. This ePTFE becomes translucent after its implantation in the stroma of rabbit cornea. The rate and density of cell growth within this polymer depends on the implant thickness, pore size, and its placement in the cornea. We have investigated the influence of the polymer permeability on the collagen and protein contents ePTFE implants. Rabbit corneal stroma were implanted with ePTFE disks (6 mm in diameter) by intralamellar keratoplasty. The implanted polymers were removed from the stroma after 3 to 6 months. The collagen and protein contents were determined after pepsin solubilization. The collagen content of the high-permeability implant was 3.7-fold greater than that of the low-permeability implant 3 months after implantation and 2.4-fold greater after 6 months. The total protein content of the high-permeability implant was 2.5-fold greater than that of low-permeability implant at 3 months and was the same after 6 months. The collagen-to-protein ratio was 68% in the high-permeability implants, and thus similar to that of normal corneal stroma. Thus, high polymer permeability increased both the rate and density of the corneal extracellular matrix ingrowth.