gebhart/patrepeval huggingface dataset:
The Structure and Function of Candida albicans Cell Wall (1991)

The wall and outer surface of pathogenic fungi is involved in adhesion and cell shape maintenance, and acts as a barrier to metabolites and drugs. In addition the cell wall contains immunogenic determinants, immunomodulators and secreted enzymes. The cell wall of C. albicans comprises some 30% of the dry weight of the cell and is composed predominantly of mannoproteins and β-glucans with small quantities of chitin, protein and lipid. Transmission electronmicroscopy of the wall reveals a number of different layers; the thickness and number of these layers varies during germ-tube formation and the cell cycle. The outer fuzzy layer of the wall contains receptors that bind plastic, laminin, fibrinogen, and C3 fragments of complement. The β1, 3 and β1, 6 glucans and chitin are the polymers which endow rigidity on the cell wall. These polymers form a microfibrillar scaffolding upon which other macromolecules, particularly mannoproteins are bound.The wall mannoproteins are highly branched polysaccharides primarily composed of mannose units attached to protein through a G 1 cNac dimer bridge and asparagine. There are also smaller numbers of 0-linked mannoproteins where the mannose units are attached to protein through serine and threonine residues. The mannoproteins have a backbone of α-1, 6 linked mannose units to which side chains of mannoses attach via α-1, 2-and occasionally α-1, 3 bonds. The side chains are the major antigenic determinants and the A and B serotypes are distinguished by differences between these side chains. A model for cell wall growth and development will is described.
Radiation from one-dimensional dielectric leaky-wave antennas (1995)

Dielectric leaky-wave antennas consist of multiple dielectric layers above a ground plane, along with a simple source such as an infinite line current in the one-dimensional case. The layers act as a guiding structure for one or more leaky waves, which are responsible for producing a narrow-beam radiation pattern. Depending on the beam angle, the leaky waves may extend for a considerable distance from the source, and thus experience truncation effects due to a finite-size substrate. One of the purposes of the present investigation is to study efficient methods for calculating the patterns under such conditions. The chirp z-transform (CZT) is shown to be very efficient for this. Simple approximate formulas for calculating the radiation pattern are also investigated. In addition, a study is also made of the different contributions to the total aperture field, including the leaky-wave field, the space-wave field, and the surface-wave field.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Run-time modeling and estimation of operating system power consumption (2003)

The increasing constraints on power consumption in many computing systems point to the need for power modeling and estimation for all components of a system. The Operating System (OS) constitutes a major software component and dissipates a significant portion of total power in many modern application executions. Therefore, modeling OS power is imperative for accurate software power evaluation, as well as power management (e.g. dynamic thermal control and equal energy scheduling) in the light of OS-intensive workloads. This paper characterizes the power behavior of a commercial OS across a wide spectrum of applications to understand OS energy profiles and then proposes various models to cost-effectively estimate its run-time energy dissipation. The proposed models rely on a few simple parameters and have various degrees of complexity and accuracy. Experiments show that compared with cycle-accurate full-system simulation, the model can predict cumulative OS energy to within 1% accuracy for a set of benchmark programs evaluated on a high-end superscalar microprocessor. When applied to track run-time OS energy profiles, the proposed routine level OS power model offers superior accuracy than a simpler, flat OS power model, yielding per-routine estimation error of less than 6%. The most striking observation is the strong correlation between power consumption and the instructions per cycle (IPC) during OS routine executions. Since tools and methodology to measure IPC exist on modern microprocessors, the proposed models can estimate OS power for run-time dynamic thermal and energy management.
Suppression of Insulin-Like Growth Factor Acid-Labile Subunit Expression—A Novel Mechanism for Deoxynivalenol-Induced Growth Retardation (2009)

Consumption of deoxynivalenol (DON), a trichothecene mycotoxin commonly detected in cereal-based foods, causes impaired growth in many animal species. While growth retardation is used as a basis for regulating DON levels in human food, the underlying mechanisms remain poorly understood. Oral exposure of mice to DON rapidly induces multiorgan expression of proinflammatory cytokines, and this is followed by upregulation of several suppressors of cytokine signaling (SOCS), some of which are capable of impairing growth hormone (GH) signaling. The purpose of this study was to test the hypothesis that impairment of the GH axis precedes DON-induced growth retardation in the mouse. Subchronic dietary exposure of young (4-week old) mice to DON (20 ppm) over a period of 2-8 weeks was found to (1) impair weight gain, (2) result in a steady-state plasma DON concentration (40-60 ng/ml), (3) downregulate hepatic insulin-like growth factor acid-labile subunit (IGFALS) mRNA expression, and (4) reduce circulating insulin-like growth factor 1 (IGF1) and IGFALS levels. Acute oral exposure to DON at 0.5-12.5 mg/kg body weight (bw) markedly suppressed hepatic IGFALS mRNA levels within 2 h in a dose-dependent fashion, whereas 0.1 mg/kg bw was without effect. DON-induced IGFALS mRNA upregulation occurred both with and without exogenous GH treatment. These latter effects co-occurred with robust hepatic suppressors of cytokine signaling 3 upregulation. Taken together, these data suggest that oral DON exposure perturbs GH axis by suppressing two clinically relevant growth-related proteins, IGFALS and IGF1. Both have potential to serve as biomarkers of effect in populations exposed to this common foodborne mycotoxin.
Design of a complementary silicon-germanium variable gain amplifier (2008)

This thesis presents an overview of the simulation, design, and measurement of state-of-the-art Silicon-Germanium Heterojunction Bipolar Transistor (SiGe HBT) variable gain amplifier (VGA). The VGA design trade-off space is presented and methods for achieving an optimized design are discussed. We demonstrate in this thesis that SiGe HBT VGA has the capability to meet the demanding needs for the next generation wireless systems.
Pancreatic Stellate Cells: Partners in Crime with Pancreatic Cancer Cells (2008)

Pancreatic stellate cells (PSC) produce the stromal reaction in pancreatic cancer, but their role in cancer progression is not fully elucidated. We examined the influence of PSCs on pancreatic cancer growth using (a) an orthotopic model of pancreatic cancer and (b) cultured human PSCs (hPSC) and human pancreatic cancer cell lines MiaPaCa-2 and Panc-1. Athymic mice received an intrapancreatic injection of saline, hPSCs, MiaPaCa-2 cells, or hPSCs + MiaPaCa-2. After 7 weeks, tumor size, metastases, and tumor histology were assessed. In vitro studies assessed the effect of cancer cell secretions on PSC migration and the effect of hPSC secretions on cancer cell proliferation, apoptosis, and migration. Possible mediators of the effects of hPSC secretions on cancer cell proliferation were examined using neutralizing antibodies. Compared with mice receiving MiaPaCa-2 cells alone, mice injected with hPSCs + MiaPaCa-2 exhibited (a) increased tumor size and regional and distant metastasis, (b) fibrotic bands (desmoplasia) containing activated PSCs within tumors, and (c) increased tumor cell numbers. In vitro studies showed that, in the presence of pancreatic cancer cells, PSC migration was significantly increased. Furthermore, hPSC secretions induced the proliferation and migration, but inhibited the apoptosis, of MiaPaCa-2 and Panc-1 cells. The proliferative effect of hPSC secretions on pancreatic cancer cells was inhibited in the presence of neutralizing antibody to platelet-derived growth factor. Our studies indicate a significant interaction between pancreatic cancer cells and stromal cells (PSCs) and imply that pancreatic cancer cells recruit stromal cells to establish an environment that promotes cancer progression.
Enhancement of mechanical properties of poly(vinyl chloride) with polymethyl methacrylate-grafted halloysite nanotube (2011)

Halloysite nanotubes(HNTs) grafted with Polymethyl methacrylate(PMMA) were synthesized via radical polymerization. The properties of PMMA-grafted HNTs were characterized by transmission electron microscopy (TEM), fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA) and X-ray photoelectron spectroscopy (XPS). The results showed that PMMA grafted to the surfaces of HNTs successfully. Then, PVC/PMMA-grafted HNTs nanocomposites were prepared by melt compounding. The morphology, mechanical properties and thermal properties of the nanocomposites were investigated. PMMA-grafted HNTs can effectively improve the toughness, strength and modulus of PVC. The glass transition and thermal decomposition temperatures of PVC phase in PVC/PMMA-grafted HNTs nanocomposites are shifted toward slightly higher temperatures. The grafted HNTs were uniformly dispersed in PVC matrix as revealed by TEM photos. The fracture surfaces of the nanocomposites exhibited plastic deformation feature indicating ductile fracture behaviors. The improvement of toughness of PVC by PMMA-grafted HNTs was attributed to the improved interfacial bonding by grafting and the toughening mechanism was explained according to the cavitation mechanism.
Functional Dynamics of GABAergic Inhibition in the Thalamus (1997)

The inhibitory gamma-aminobutyric acid-containing (GABAergic) neurons of the thalamic reticular and perigeniculate nuclei are involved in the generation of normal and abnormal synchronized activity in thalamocortical networks. An important factor controlling the generation of activity in this system is the amplitude and duration of inhibitory postsynaptic potentials (IPSPs) in thalamocortical cells, which depend on the pattern of activity generated in thalamic reticular and perigeniculate cells. Activation of single ferret perigeniculate neurons generated three distinct patterns of GABAergic IPSPs in thalamocortical neurons of the dorsal lateral geniculate nucleus: Low-frequency tonic discharge resulted in small-amplitude IPSPs mediated by GABAA receptors, burst firing resulted in large-amplitude GABAA IPSPs, and prolonged burst firing activated IPSPs mediated by GABAA and GABAB receptors. These functional properties of GABAergic inhibition can reconfigure the operations of thalamocortical networks into patterns of activity associated with waking, slow-wave sleep, and generalized seizures.
Performance comparison of direct membrane separation and membrane bioreactor for domestic wastewater treatment and water reuse (2001)

Two pilot-scale wastewater treatment systems - direct membrane separation (DMS) and membrane bioreactor (MBR) systems - were designed and constructed in order to investigate the feasibility of membrane filtration technology for domestic wastewater treatment and water reuse. A submerged-type hollow-fiber microfiltration (HF-MF) membrane module with pore size of 0.1μm was employed to build each pilot system. The systems were tested using low- and high-strength domestic wastewaters and the system performance was continuously monitored for a long period to compare filtration characteristics and effluent quality in each system. The MBR system showed much better performance than the DMS system in terms of filtration characteristics and effluent quality. Even though the mixed-liquor suspended solid (MLSS) content in the MBR system was much higher than that in the DMS system, the MBR filtration resistance was much lower than the DMS filtration resistance. The DMS system was not able to remove dissolved organic matter, which seemed to be a major component of membrane fouling. The MBR effluent quality such as COD, BOD, TOC and T-N was more stable and better than the DMS. In the MBR process, the organic removal efficiency remained more than 95% regardless of fluctuation in influent qualities. The effluent quality of both systems was satisfying the legal standards for water reuse in Korea. Rejection of pathogenic microorganisms by membrane filtration was also investigated.
Isolation and Some Characteristics of a Subgroup J-Like Avian Leukosis Virus Associated with Myeloid Leukosis in Meat-Type Chickens in the United States (1999)

Several subgroup J-like avian leukosis viruses (ALV-Js) were isolated from broiler breeder (BB) and commercial broiler flocks experiencing myeloid leukosis (ML) at 4 wk of age or older. In all cases, diagnosis of ML was based on the presence of typical gross and microscopic lesions in affected tissues. The isolates were classified as ALV-J by 1) their ability to propagate in chicken embryo fibroblasts (CEF) that are resistant to avian leukosis virus (ALV) subgroups A and E (C/AE) and 2) positive reaction in a polymerase chain reaction with primers specific for ALV-J. The prototype strain of these isolates, an isolate termed ADOL-Hc1, was obtained from an adult BB flock that had a history of ML. The ADOL-Hc1 was isolated and propagated on C/AE CEF and was distinct antigenically from ALV of subgroups A, B, C, D, and E, as determined by virus neutralization tests. Antibody to ADOL-Hc1 neutralized strain HPRS-103, the prototype of ALV-J isolated from meat-type chickens in the United Kingdom, but antibody to HPRS-103 did not neutralize strain ADOL-Hc1. On the basis of both viremia and antibody, prevalence of ALV-J infection in affected flocks was as high as 87%. Viremia in day-old chicks of three different hatches from a BB flock naturally infected with ALV-J varied from 4% to 25%; in two of the three hatches, 100% of chicks that tested negative for virus at hatch had evidence of viremia by 8 wk of age. The data document the isolation of ALV-J from meat-type chickens experiencing ML as young as 4 wk of age. The data also suggest that strain ADOL-Hc1 is antigenically related, but not identical, to strain HPRS-103 and that contact transmission of ALV-J is efficient and can lead to tolerant infection.
Soluble polypyrrole copolymers (2001)

Abstract A new class of dimethyl formamide (DMF)– and acetone‐soluble conducting pyrrole–ketonic resin copolymers has been developed. This was accomplished by oxidatively polymerizing pyrrole monomer by Ce(IV) salt in the presence of methyl ethyl ketone formaldehyde resin (MEKF–R). The resulting copolymers were readily dissolved in DMF and acetone. These products were characterized by FTIR and UV‐visible spectroscopy, conductivity, four‐probe conductivity, viscosity, and DSC measurements. © 2001 John Wiley & Sons, Inc. J Appl Polym Sci 82: 1098–1106, 2001
Mechanism of the Reflex Depressor Effect by Kidney in Dog (1967)

The mechanism of the reflex depressor function from the kidney was studied in anesthetized dogs with penthobarbitone sodium under artificial breathing. The action potentials of the efferent renal nerve (sympathetic) decreased by compression of the kidney and renal vein occlusion, and were followed by a fall in the systemic arterial pressure. The efferent action potentials were slightly increased or unchanged by renal artery occlusion but were followed by a rise in the systemic arterial pressure. The action potentials of the afferent renal nerve increased with the rise in the intrarenal pressure produced by compression of the kidney, by renal vein occlusion, and by elevation of the perfusion pressure of the kidney in cross-perfusion experiments. The afferent discharge decreased with the fall in the intrarenal pressure produced by renal artery occlusion. The action potentials of the efferent nerve decreased by electric stimulation of the afferent nerve, and were followed by a fall in the systemic arterial pressure. The action potentials of the afferent nerve evoked by compression of the kidney, by elevation of the intrapelvic pressure, and by renal vein occlusion, did not vanish after subcapsular and intrapelvic injection of 2% procaine or after total decapsulation. The evoked action potentials disappeared after injection of procaine into the renal artery. It was concluded from these data that the receptor, which is sensitive to the changes of the intrarenal pressure, is activated by elevation of the intrarenal pressure and causes reflex hypotension by means of the inhibition of the sympathetic discharge.
Measurement and analysis of the dynamics of mechanical structures (1979)

This paper discusses modern methods of testing, modeling, and analyzing the dynamics of mechanical structures. The topics covered are mathematical modeling of structural dynamics, modes of vibration, the normal mode versus the transfer function technique for structural testing, and identifying modal parameters from transfer function measurements. As indicated, much of the discussion concerns the modes of vibration of mechanical structures which turn out to be the link between the testing and analysis methods discussed in this paper. These methods are based upon the use of digital computers, and algorithms such as the finite element method for modeling and analysis, and digital filtering such as the fast Fourier transform for dynamic measurements. Some of the latest techniques for graphically displaying modes of vibration using low cost measurement instrumentation will also be presented.
Clonal deletion as the mechanism of abrogation of immunological memory following liver grafting in rats. (1985)

In the rat strain combination of DA into PVG, an orthotopic liver graft has the ability to abrogate an existing state of sensitization against donor (DA) antigens. Fifty-four percent of PVG rats sensitized against DA by skin grafting accepted a DA liver graft permanently, and about half of these became systemically tolerant of DA MHC antigens, as demonstrated by permanent acceptance of a subsequent (second-set) DA skin or heart graft. The cellular basis of this tolerant state was studied in vivo. An adoptive transfer assay provided evidence for functional deletion of DA-reactive cells responsible for graft rejection from the recirculating lymphocyte pool. There was no evidence of a role for suppressor T cells in maintaining tolerance. However, a graft-versus-host assay showed normal reactivity in thoracic duct lymphocytes from tolerant animals. Hence, specific clonal deletion is apparently responsible for the abolition of immunological memory by liver grafting, but is selective in respect of the sets of alloreactive lymphocytes affected.
Metal content and particle size distribution of street sediments and street sweeping waste (2002)

During recent years the interest in street sweeping as a pollutant control measure has increased. For planning of street sweeping programs and disposal of street sweeping waste there is a need to investigate the composition of street sweeping waste and the effect of street sweeping on the remaining sediments on the street. Particle size distribution and heavy metal concentration has been measured for street sweeping waste, street sediments before sweeping and remaining sediments after sweeping. The results show that the concentrations of heavy metals are a function of particle diameter and proportional to the inverse of the particle diameter, i.e. the highest concentrations are found in finest fractions. Regression equations for metal concentrations as a function of particle diameter are presented. According to Swedish guidelines for environmental quality of contaminated sites, heavy metal concentration in the sweeping waste can not be considered as a serious problem. The largest amount of metals and sediment is found in the sandy fractions (0.125-0.5 mm). The street sweeper is more effective in removing coarse sediments than fine. This means that the street sediments after sweeping are finer than the sediments before.
Microglial Activation Correlates with Disease Progression and Upper Motor Neuron Clinical Symptoms in Amyotrophic Lateral Sclerosis (2012)

This study demonstrates that microglial pathology in the CST of ALS correlates with disease progression and is linked to severity of UMN deficits.
Quasi-Circulator Using an Asymmetric Coupler for Tx Leakage Cancellation (2018)

A quasi-circulator is proposed by using an asymmetric coupler with high isolation between the transmitting (Tx) and receiving (Rx) ports. The proposed quasi-circulator consists of quarter-wave transmission lines, which have unbalanced characteristic impedances and the terminated port, which is purposely unmatched with the reference impedance in the coupler. The port compensates for the asymmetric impedances of the coupler using the proposed design parameter. Because of its asymmetric structure and the usage of the unmatched port, the proposed circulator can be accurately designed to have high Tx–Rx isolation without increasing the signal losses in the Tx and Rx paths at the operating frequency. The proposed quasi-circulators show isolation improvements of 9.07 dB at 2.45 GHz and 7.95 dB at 24.125 GHz compared with conventional circulators using the symmetric couplers. The characteristic improvement of the proposed quasi-circulator was demonstrated by the increase of the detectable range of the 2.45 GHz Doppler radar sensor with the quasi-circulator.
Compressing inverted files in scalable information systems by binary decision diagram encoding (2001)

One of the key challenges of managing very huge volumes of data in scalable Information retrieval systems is providing fast access through keyword searches. The major data structure in the information retrieval system is an inverted file, which records the positions of each term in the documents. When the information set substantially grows, the number of terms and documents are significantly increased as well as the size of the inverted files.Approaches to reduce the inverted file without sacrificing the query efficiency are important to the success of scalable information systems. In this paper, we propose a compression approach by using Binary Decision Diagram Encoding (BDD) so that all possible ordering correlation among large amount of documents will be extracted to minimize the posting representation. Another advantage of using BDD is that BDD expressions can efficiently perform Boolean queries, which are very common in retrieval systems. Experiment results show that the compression ratios of the inverted files have been improved significantly by the BDD scheme.
Mannan‐Binding Lectin in the Sub‐Saharan HIV and Tuberculosis Epidemics (1997)

Inherited deficiency of mannan-binding lectin (MBL) has been shown to predispose to infections. Conversely, it has also been suggested that MBL might facilitate the uptake of certain intracellular microbes. The aim of this study was to investigate whether MBL plays a role in the HIV and tuberculosis epidemics in Africa. Thus, the authors determined the MBL serum concentration in 173 HIV infected patients (150 with concomitant tuberculosis), 94 patients with tuberculosis without being HIV infected, and 113 controls from Tanzania. The frequency of MBL deficiency was significantly increased in HIV infected patients compared with controls (12.1% and 3.5%, respectively). The frequency of patients deficient of MBL did not differ between controls and HIV negative patients with tuberculosis. However, HIV negative patients with tuberculosis had significantly higher MBL levels than both controls and HIV infected patients with or without tuberculosis. These results indicate that low levels of MBL are associated with increased risk of sexually transmitted HIV infection in Africans. By contrast, high levels of MBL may be involved in the pathogenesis of tuberculosis in immunocompetent individuals.