gebhart/patrepeval huggingface dataset:
Epidermal Growth Factor and Trefoil Factor Family 2 Synergistically Trigger Chemotaxis on BEAS-2B Cells via Different Signaling Cascades (2004)

Injured areas of the respiratory epithelium are subject to rapid repair by the migration of adjacent epithelial cells, a process termed "restitution". Rapid re-epithelialization is promoted by interactions between migrating cells and the extracellular matrix proteins. Furthermore, epidermal growth factor (EGF) as well as trefoil factor family (TFF) peptides are well known regulators of epithelial restitution due to their motogenic effects. Migration of the human bronchial epithelial cell line BEAS-2B in modified Boyden chambers was used as a model system for airway restitution. EGF or recombinant human TFF2 or TFF3 showed mainly chemotactic activity. The motogenic response was strictly dependent upon a haptotactic substrate, but to different degrees. EGF induced phosphorylation of extracellular signal-regulated kinases (ERK) 1/2, c-Jun-N-terminal kinase, p38, Akt, and p70S6K in BEAS-2B cells. Using specific inhibitors, the signaling cascades responsible for the motogenic response were shown to differ drastically when EGF was compared with TFF2. The motogenic effect of TFF2 was previously demonstrated to depend on ERK1/2 and protein kinase C activation; whereas the EGF-triggered motogenic response was completely independent of ERK1/2 activation but sensitive to the inhibition of phosphoinositide 3-kinase, p38, protein kinase C, or nuclear factor kappaB. However, the motogenic effects of EGF and TFF2 are additive. These data suggest that luminal EGF and TFF peptides can act synergistically in the human respiratory epithelium to enhance rapid repair processes in the course of diseases such as asthma.
Classification of 3 DES supernova with OzDES and DEVILS (2018)

We report new spectroscopic classifications by OzDES and DEVILS of supernovae discovered by the Dark Energy Survey (ATEL #4668). The spectra (370-885nm) were obtained with the AAOmega Spectrograph (Saunders et al. 2004, SPIE, 5492, 389) and the 2dF fibre positioner at the Anglo-Australian Telescope (AAT). <p/>
Third party arbitration under English law (2016)

Arbitration agreements should be exclusively binding on the parties who enter them. However, there are situations in which third parties, such as the guarantor, successor, consignor or subsidiary company, are usually beyond the status of genuine parties to the agreement, although they cab invoke or be bound by the agreement owing to the common rights and liabilities between those parties, as they have an active role concerning the execution of the contract. These situations raise several issues concerning when the third party to an arbitration agreement would be entitled to intervene in the proceedings, and when a party to the proceedings is able to join non-parties to the arbitration proceedings. This paper examines these maters under English law, demonstrating that it fails to provide legal certainty to third parties. The paper concludes with a recommendation for appropriate regulation to adjust "third parties in arbitration" at national, regional and international levels, owing to the disparity of case judgments in this area of law.
Myocardial Uptake of 7′-(Z)-[ <sup>123</sup> I]Iodorotenone During Vasodilator Stress in Dogs With Critical Coronary Stenoses (2011)

The ability of (123)I-ZIROT to more linearly track blood flow over a wide range makes it a promising new SPECT myocardial perfusion imaging agent with potential for improved coronary artery disease detection and better quantitative estimation of the severity of flow impairment.
In Vitro and Ex Vivo Inhibition of the Modification of Low-Density Lipoprotein by Indapamide (1992)

The effect of an antihypertensive drug, indapamide, on copper- and endothelial cell-induced peroxidation of human low-density lipoprotein (LDL) was studied and compared with that of drugs previously shown to protect LDL against peroxidation: probucol and vitamin E and other thiazidic and nonthiazidic diuretics (clopamide, hydrochlorothiazide, and furosemide). Incubation with indapamide inhibited in a dose-dependent manner LDL peroxidation induced either by copper ions or by cultured endothelial cells. Both electrophoretic mobility and thiobarbituric acid-reactive substances (TBARS) content of LDL returned to almost normal values in the presence of 1 microM indapamide. This drug was at least 10 times more potent than probucol and vitamin E in inhibiting LDL peroxidation. No inhibitory effect has been observed with clopamide, hydrochlorothiazide, and furosemide in the same experimental conditions. Homozygote Watanabe rabbits were treated orally with indapamide (10 mg/kg/d for 3 days) to evaluate the potential protective effect of the compound on LDL peroxidation in vivo. Purified LDL from placebo and treated rabbits were submitted to peroxidation induced by copper ions, and indapamide was effectively able to protect LDL in these experimental conditions. This effect was especially obvious 6 and 8 h after the start of the incubation when LDL of the placebo-treated animals were modified. The mechanism of action of these drugs was examined in vitro using the 1,1-diphenyl-2-picryl-hydrazyl (DPPH) test and in kinetic studies of arachidonic acid photoperoxidation. Indapamide as well as vitamin E and probucol were effective free radical scavengers, but the other diuretic molecules were not.(ABSTRACT TRUNCATED AT 250 WORDS)
Multiple description video coding for scalable and robust transmission over IP (2005)

In this paper, we address the problem of video transmission over unreliable networks, such as the Internet, where packet losses occur. The most recent literature indicates multiple description (MD) as a promising coding approach to handle this issue. Moreover, it has been shown also how important the use of motion compensation prediction is in an MD-coding scheme. This paper proposes two architectures for multiple description video coding, both of them are based on the motion compensation prediction loop. The common characteristic of the two architectures is the use of a polyphase down-sampling technique to create the MDs and to introduce cross-redundancy among the descriptions. The first scheme, that we call drift-compensation multiple description video coder (DC-MDVC) appears very robust when used in an error-prone environment, but it can provide only two descriptions. The second architecture, called independent flow multiple description video coder (IF-MDVC), generates multiple sets of data before the motion compensation loop; in this case, there are no severe limitations in the selection of the number of descriptions used by the coder.
Dispensability and dynamics of caveolin-1 during liver regeneration and in isolated hepatic cells (2007)

These results support a dynamic role for Cav-1 in liver proliferation both in vivo after PH and in vitro in cultured hepatic cell lines, but with minimal implications for the liver regeneration process.
Growth factors in lung cancer: Possible etiologic role and clinical target (1991)

Growth factors play an important role in the pathogenesis and progression of all histologic types of lung cancer. Ideas for the exploitation of growth factors in lung cancer management are growing. The inhibition of the interaction between growth factors and their receptors, utilization of negative growth factors, interruption of the signal transduction pathways, or effecting decreased growth factor and/or receptor expression, could result in cell death, and all seem logical possibilities for new and specific treatment approaches. There can be no question that observations of the abnormal expression of growth factors have made a startling impact in every aspect of cancer research. The elucidation of their role in cell proliferation, coupled with our growing knowledge of the functions of oncogenes, has given birth to a unifying concept for the etiology of malignant transformation, which hopefully will translate into new, less toxic, more effective, and desperately needed lung cancer treatment.
Delayed DNA joining at 3' mismatches by human DNA ligases (1999)

Repair synthesis catalysed by DNA polymerase beta at 1 nt gaps occurs in the main pathway of mammalian base excision repair. DNA polymerase beta has no exonucleolytic proof-reading ability, and exhibits high error frequency during DNA synthesis. Consequently, continuous correction of endogenous DNA damage by short-patch repair synthesis might lead to a high spontaneous mutation rate, unless subsequent steps in the repair pathway allow for selective removal of incorporation errors. We show here that both human DNA ligase I and III discriminate strongly between a correctly paired versus a mispaired residue at the 3' position of a nick in DNA, when assayed in the presence of physiological concentrations of KCl. The resulting delay in joining after misincorporation by DNA polymerase beta during gap filling could allow for removal of the mismatched terminal residue by a distinct 3' exonuclease.
Nanosecond fluorescence microscopy of single cells (1990)

A microscope based time-correlated single photon counting instrument has been used to measure nanosecond fluorescence decays from single cells. The excitation source for the instrument is a frequency doubled train of picosecond pulses from the cavity dumped output of a synchronously pumped dye laser. The dye laser is pumped by a mode-locked argon ion laser. In the microscope, the sample is excited and the emission collected using epi-illumination optics before being transmitted through an adjustable diaphragm, which can be closed to 10 μm in diameter. A Hamamatsu R928 photomultiplier is used to collect the fluorescence which is then analyzed using a non-linear least squares procedure. The microscope has been used to measure the intensity decays of model probes to determine the instrument performance and sensitivity. In addition, intensity and anisotropy decays collected from fura-2 loaded into single adherent rat basophilic leukemia cells were measured to demonstrate that the nanosecond fluorescence microscope can be used to obtain information about the environment and mobility of fluorescent probes in single cells.
Single-leakage-channel grating couplers: comparison of theoretical and experimental branching ratios (1993)

Fabrication and characterization of a waveguide grating that is highly efficient in producing a single channel of output-coupled light are described. The thin-film assembly consisted of a waveguide-grating system fabricated upon a highly reflecting dielectric stack and isolated by a thick buffer layer. This single-leakage-channel grating coupler utilized the reflectance of the dielectric stack to redirect the light output coupled toward the substrate back into air, where it constructively interfered with light initially output coupled into air. Measured branching ratios were compared with values predicted by a rigorous computer model and agreed to within 2%. Experimental branching ratio values exceeding 98% were obtained.
A Hybrid Movie Recommender Based on Ontology and Neural Networks (2010)

In order to make recommendations to a user, a recommender mainly uses two approaches: content-based-filtering approach and collaborative filtering approach. However, they both still have some shortcomings technically. The content-based approach is difficult to handle feature extraction as well as user intension prediction. The collaborative approach faces the hard issue of cold start problem and the matrix sparsity problem. In this paper, we present an novel hybrid recommendation approach based on Ontology and Neural Network in the movie domain. The approach combines content-based filtering and collaborative-filtering and a recommender can use them individually or use them both. The hybrid recommendation approach can tackle the traditional recommenders - problems, such as feature extraction, intension prediction, matrix sparsity and cold start problems. Our experiments show that, our approach provides a good method to make recommendations to users.
Lewis acid–base interactions enhance explosives sensing in silacycle polymers (2009)

The high sensitivity of silole- and silafluorene-containing polymers for detecting organic nitro, nitrate, and nitramine explosives cannot be solely attributed to favorable analyte-polymer hydrophobic interactions and amplified fluorescence quenching due to delocalization along the polymer chain. The Lewis acidity of silicon in conjugated poly(silafluorene-vinylene)s is shown to be important. This was established by examining the (29)Si NMR chemical shifts (Delta) for the model trimer fragment of the polymer CH(3)-silafluorene-(trans-C(2)H(2))-silafluorene-(trans-C(2)H(2))-silafluorene-CH(3). The peripheral and central silicon resonances are up-field from a TMS reference at -9.50 and -18.9 ppm, respectively. Both resonances shift down-field in the presence of donor analytes and the observed shifts (0 to 1 ppm) correlate with the basicity of a variety of added Lewis bases, including TNT. The most basic analyte studied was acetonitrile and an association constant (K(a)) of 0.12 M(-1) was calculated its binding to the peripheral silicon centers using the Scatchard method. Spin-lattice relaxation times (T(1)) of 5.86(3) and 4.83(4) s were measured for the methyl protons of acetonitrile in benzene-d(6) at 20 degrees C in the absence and presence of the silafluorene trimer, respectively. The significant change in T(1) values further supports a binding event between acetonitrile and the silafluorene trimer. These studies as well as significant changes and shifts observed in the characteristic UV-Vis absorption of the silafluorene group support an important role for the Lewis acid character of Si in polymer sensors that incorporate strained silacycles. The nitro groups of high explosives may act as weak Lewis-base donors to silacycles. This provides a donor-acceptor interaction that may be crucial for orienting the explosive analyte in the polymer film to provide an efficient pathway for inner-sphere electron transfer during the electron-transfer quenching process.
Hepatitis C Virus Infection in Phenotypically Distinct Huh7 Cell Lines (2009)

In 2005, the first robust hepatitis C virus (HCV) infectious cell culture system was developed based on the HCV genotype 2a JFH-1 molecular clone and the human-derived hepatoma cell line Huh7. Although much effort has been made to dissect and expand the repertoire of JFH-1-derived clones, less attention has been given to the host cell despite the intriguing facts that thus far only Huh7 cells have been found to be highly permissive for HCV infection and furthermore only a limited number of Huh7 cell lines/stocks appear to be fully permissive. As such, we compiled a panel of Huh7 lines from disparate sources and evaluated their permissiveness for HCV infection. We found that although Huh7 lines from different laboratories do vary in morphology and cell growth, the majority (8 out of 9) were highly permissive for infection, as demonstrated by robust HCV RNA and de novo infectious virion production following infection. While HCV RNA levels achieved in the 8 permissive cell lines were relatively equivalent, three Huh7 lines demonstrated higher infectious virion production suggesting these cell lines more efficiently support post-replication event(s) in the viral life cycle. Consistent with previous studies, the single Huh7 line found to be relatively resistant to infection demonstrated a block in HCV entry. These studies not only suggest that the majority of Huh7 cell lines in different laboratories are in fact highly permissive for HCV infection, but also identify phenotypically distinct Huh7 lines, which may facilitate studies investigating the cellular determinants of HCV infection.
Secure high data embedding rate for steganographic application (2000)

Data hiding is the process of secretly embedding information inside a data source without changing its perceptual quality or its statistical properties. In this paper we present a new data hiding technique for embedding a high data rate in the transform domain. This technique is suitable for applications such as covert communication and captioning. The technique is based on increasing the number of image transform coefficients used to carry the information by decorrelating the image samples in the spatial domain. The embedding technique does not introduce noticeable changes neither in the perceptual quality nor in the statistical properties of the cover image. Hence, it is considered to be secure.
Investigation of new low-loss and high-power SAW filters for reverse-frequency-allocated cellular radios (1993)

Japanese cellular radios employ reverse frequency-allocations of the transmitter and receiver frequency bands. A rather narrowband surface acoustic wave (SAW) transmitter prefilter and a new type of SAW low-loss and high-power transmitter final stage filter-dual configurations to previously developed US cellular radio system filter-have been developed. The dual configurations provide the stopbands for the filter at the lower side of the pass bands, which is a requirement for reverse frequency-allocation systems. Design procedures, including those for the piezoelectric substrates and the experimental results obtained for the filters of 1.5 dB low insertion-loss and over 30 dB stop band rejection at 920 MHz, are also presented. In addition, the frequency characteristics of the SAW antenna duplexer module used in Japanese new common carrier (NCC) systems are discussed.
A cost model for broadband access networks: FTTx versus WiMAX (2007)

Local communities and governments are taking various steps to fight the so-called "digital divide" between well served urban communities and undeserved areas. In order to make broadband access available to these under served areas, several technical solutions are available with the capacity to provide high speed Internet access, video, telephony services, etc. This paper presents a cost-model and a tool for the evaluation of broadband access technologies (xDSL, HFC, FTTx, WiMAX, PLC and satellite), and compares two technologies: FTTx and WiMAX. Our tool compares these different access technologies in different scenarios, and examining the capital expense and deployment of building access networks with the same requisite performance using each technology. The cost model is limited to the access part of the network. The results obtained by our evaluation tool give the possibility to compare several BB access technologies, and support the decision about which is the better technological solution for a given scenario
Germinal center responses to complex antigens (2018)

Germinal centers (GCs) are the primary sites of antibody affinity maturation, sites where B-cell antigen-receptor (BCR) genes rapidly acquire mutations and are selected for increasing affinity for antigen. This process of hypermutation and affinity-driven selection results in the clonal expansion of B cells expressing mutated BCRs and acts to hone the antibody repertoire for greater avidity and specificity. Remarkably, whereas the process of affinity maturation has been confirmed in a number of laboratories, models for how affinity maturation in GCs operates are largely from studies of genetically restricted B-cell populations competing for a single hapten epitope. Much less is known about GC responses to complex antigens, which involve both inter- and intraclonal competition for many epitopes. In this review, we (i) compare current methods for analysis of the GC B-cell repertoire, (ii) describe recent studies of GC population dynamics in response to complex antigens, discussing how the observed repertoire changes support or depart from the standard model of clonal selection, and (iii) speculate on the nature and potential importance of the large fraction of GC B cells that do not appear to interact with native antigen.
Potential Use of Atlantic Cod Trypsin in Biomedicine (2013)

Surface proteins of viruses and bacteria used for cell attachment and invasion are candidates for degradation by proteases. Trypsin from Atlantic cod (Gadus morhua) was previously demonstrated to have efficacy against influenza viruses in vitro and on skin. In this paper, cod trypsin is shown to be 3-12 times more effective in degrading large native proteins than its mesophilic analogue, bovine trypsin. This is in agreement with previous findings where cod trypsin was found to be the most active among twelve different proteases in cleaving various cytokines and pathological proteins. Furthermore, our results show that cod trypsin has high efficacy against herpes simplex virus type 1 (HSV-1) and the respiratory syncytial virus (RSV) in vitro. The results on the antipathogenic properties of cod trypsin are important because rhinovirus, RSV, and influenza are the most predominant pathogenic viruses in upper respiratory tract infections. Results from a clinical study presented in this paper show that a specific formulation containing cod trypsin was preferred for wound healing over other methods used in the study. Apparently, the high digestive ability of the cold-adapted cod trypsin towards large native proteins plays a role in its efficacy against pathogens and its positive effects on wounds.
Dual-channel flame infrared emission detector for gas chromatography (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDual-channel flame infrared emission detector for gas chromatographyS. Ravishankar, D. C. Tilotta, S. W. Kubala, M. A. Busch, and K. W. BuschCite this: Anal. Chem. 1990, 62, 15, 1604–1610Publication Date (Print):August 1, 1990Publication History Published online1 May 2002Published inissue 1 August 1990https://pubs.acs.org/doi/10.1021/ac00214a013https://doi.org/10.1021/ac00214a013research-articleACS PublicationsRequest reuse permissionsArticle Views64Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts