gebhart/patrepeval huggingface dataset:
A Learning Approach for Call Admission Control under QoS Constraints in Cellular Networks (2006)

A new approach for learning call admission control (CAC) schemes that can provide quality of service (QoS) guarantees to ongoing calls from several classes of traffic with different resource requirements is presented. Comparison with two other CAC schemes shows that the new approach is not only capable of utilizing the network resource to maximize revenue but also maintain the handover dropping rate (CDR) under a prescribed upper bound while still maintaining an acceptable call blocking rate (CBR). The learning CAC scheme is shown to work successfully in the presence of smoothly changing arrival rates of traffic. The CAC policy is obtained through a form of neuroevolution (NE) algorithm
Synthesis and properties of alternating polymers containing 2,6-diaryldithienosilole and organosilicon units (2000)

Nickel-complex-catalyzed dehalogenative coupling of diGrignard reagents prepared from bis(bromoaryl)disilanes or monosilane with 2,6-dibromodithienosiloles afforded the corresponding polymers composed of alternating 2,6-diaryldithienosilole and organosilicon units. These polymers exhibit strong UV-vis absorption and emission bands at 422–444 and 482–541 nm, respectively. Their cyclic voltammograms display the first oxidation peaks at 0.95–1.00 V vs. SCE (saturated Calomel electrode). When the polymer films were doped with FeCl3 vapor, the films became conducting, and their conductivities were determined to be 3.3×10–5 – 8.7×10–3 S/cm using the four probe method. Electron- and hole-transporting properties of the polymers were also studied by evaluating the performance of electroluminescent (EL) devices based on these polymers.
Duplicate detection in click streams (2005)

We consider the problem of finding duplicates in data streams. Duplicate detection in data streams is utilized in various applications including fraud detection. We develop a solution based on Bloom Filters [9], and discuss the space and time requirements for running the proposed algorithm in both the contexts of sliding, and landmark stream windows. We run a comprehensive set of experiments, using both real and synthetic click streams, to evaluate the performance of the proposed solution. The results demonstrate that the proposed solution yields extremely low error rates.
The role of mTOR in memory CD8<sup>+</sup> T‐cell differentiation (2010)

The mammalian target of rapamycin (mTOR) is an intracellular kinase that regulates cell growth and metabolism. Its specific inhibitor rapamycin is currently used in transplant recipients as an immunosuppressive drug to prevent allograft rejection. Studies have shown complex and diverse mechanisms for the immunosuppressive effects of rapamycin. The drug has been reported to inhibit T-cell proliferation, induce anergy, modulate T-cell trafficking, promote regulatory T cells, and also prevent maturation of dendritic cells as well as production of type I interferon. However, several other studies have paradoxically demonstrated immunostimulatory effects of rapamycin by improving antigen presentation and regulating cytokine production from macrophages and myeloid dendritic cells. Recently, it has been shown that rapamycin also exhibits immunostimulatory effects on memory CD8(+) T-cell differentiation. The drug improved both quantity and quality of memory CD8(+) T cells induced by viral infection and vaccination, showing that mTOR is a major regulator of memory CD8(+) T-cell differentiation. These discoveries have implications for the development of novel vaccine regimens. Here, we review the role of mTOR in memory CD8(+) T-cell differentiation and compare the effect of rapamycin among CD8(+) T cells, CD4(+) T cells, and dendritic cells. Also, we discuss potential application of these findings in a clinical setting.
Practical Feature Selection: from Correlation to Causality (2008)

Feature selection encompasses a wide variety of methods for selecting a restricted number of input variables or &ldquo;features&rdquo;, which are &ldquo;relevant&rdquo; to a problem at hand. In this chapter, we guide practitioners through the maze of methods, which have recently appeared in the literature, particularly for supervised feature selection. Starting from the simplest methods of feature ranking with correlation coefficients, we branch in various direction and explore various topics, including &ldquo;conditional relevance&rdquo;, &ldquo;local relevance&rdquo;, &ldquo;multivariate selection&rdquo;, and &ldquo;causal relevance&rdquo;. We make recommendations for assessment methods and stress the importance of matching the complexity of the method employed to the available amount of training data. Software and teaching material associated with this tutorial are available [12].
A method for reducing body exposure to electromagnetic field of pillow type wireless charger in fully implantable middle ear hearing device (2009)

Implantable middle ear hearing devices (IMEHDs) have been developed at several countries. Some devices can be selected rechargeable battery for long-term implant. In South Korea, a kind of IMEHD with rechargeable battery and a pillow type wireless charger have been developed. The charger includes several coils surrounding user's head in sleep. However, this device should excessively consume power due to driving all primary coils. Especially, needless exposure to magnetic field generated from uncoupled primary coils may induce bio-hazards. Therefore, a method reducing the body exposure to electromagnetic field was proposed as decreasing the emitted total magnetic flux during charge process.
Overcoming Obstacles to Drug Repositioning in Japan (2017)

Drug repositioning (DR) is the process of identifying new indications for existing drugs. DR usually focuses on drugs that have cleared phase-I safety trials but has yet to show efficacy for the intended indication. Therefore, DR can probably skip the preclinical and phase-I study, which can reduce the cost throughout drug development. However, the expensive phase-II/III trials are required to establish efficacy. The obstacles to DR include identification of new indications with a high success rate in clinical studies, obtaining funding for clinical studies, patent protection, and approval systems. To tackle these obstacles, various approaches have been applied to DR worldwide. In this perspective, we provide representative examples of DR and discuss the ongoing efforts to overcome obstacles to DR in Japan.
eNOS Activity Is Reduced in Senescent Human Endothelial Cells (2001)

Advanced age is associated with endothelial dysfunction and increased risk for atherosclerosis. However, the mechanisms for these observed effects are not clear. To clarify the association between aging and loss of endothelial function, young human aortic endothelial cells (HAECs), senescent HAECs transfected with control vector, and immortalized HAECs containing human telomerase reverse transcriptase (hTERT) were compared for expression of endothelial nitric oxide synthase (eNOS) and production of NO. To investigate a specific function modulated by endothelial NO, adhesion of monocytes under basal conditions as well as after exposure to TNF-alpha was assessed. A decrease in eNOS mRNA, protein, and activity was observed in endothelial cells at senescence as compared with young HAEC; this effect was blunted in hTERT cells. In all cells, shear stress induced a greater increase in the expression of eNOS protein with the final result being higher levels in hTERT compared with senescent cells. Basal monocyte binding was significantly elevated on aged endothelial cells compared with parental and hTERT cells. Exposure of TNF-alpha resulted in a 2-fold increase in monocyte adhesion in senescent cells, whereas this effect was reduced in cells transfected with hTERT. Prior exposure to fluid flow significantly reduced subsequent monocyte adhesion in all groups. These studies demonstrate that replicative aging results in decreased endothelial expression of eNOS accompanied by enhanced monocyte binding. Stable expression of hTERT results in endothelial cells with a younger phenotype with greater amount of eNOS and NO activity. Thus, telomerase transfection may have important functional consequences on endothelial cells.
Charge pump controller for grounded piezoelectric actuators used in precise positioning (2011)

A charge pump controller adapted for grounded piezoelectric loads is proposed. By transferring charge packets into the piezoelectric actuator step by step, the actuator deforms with much less hysteresis and ultra-high resolution. Compared with voltage drive, the actuator hysteresis is reduced by 71–83% over a frequency range of 0.01–0.1 Hz.
Human-Swarm Interface for Abstraction Based Control (2009)

Decentralized control of a large number of agents acting as a single swarm is an active\n\n¯eld of research. More recently the problem of how to instruct the swarm to perform\n\ncertain tasks, and in particular, how to interface the swarm to a human operator has\n\narisen. This paper describes a Human Swarm Interface under development at University\n\nof Pisa which aims at providing the human operator with an easy to use display console and\n\nan input device which allows him/her to intuitively control and monitor a swarm position\n\nand shape over time. The swarm position and shape is de¯ned using an abstraction based\n\napproach; each single swarm agent estimates the swarm state via a distributed consensus\n\nalgorithm and moves according to a steepest descent algorithm toward minimization of the\n\nerror between human operator command and swarm state. The paper presents some new\n\ndevelopments of the DEAS testbed as well, where the proposed interface is implemented\n\nand tested, which face the issues of inter agent synchronization and con°ict-free wireless\n\ncommunications. Simulation and experimental results are shown.
Selection of Concept Detectors for Video Search by Ontology-Enriched Semantic Spaces (2008)

This paper describes the construction and utilization of two novel semantic spaces, namely ontology-enriched semantic space (OSS) and ontology-enriched orthogonal semantic space (OS <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ), to facilitate the selection of concept detectors for video search. These two semantic spaces are enriched with ontology knowledge, while emphasizing consistent and uniform comparison of ontological relatedness among concepts for query-to-concept mapping. OS <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> , in addition to being a linear space like OSS, also guarantees orthogonality of the semantic space. Compared with other ontology reasoning measures, both spaces are capable of providing platforms that offer a global view of concept inter-relatedness, by allowing evaluation of concept similarity in metric spaces. We simulate OSS and OS <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> by using LSCOM concepts and experiment search effectiveness with VIREO-374 concept detectors. Empirical observations indicate that the proposed semantic spaces enable more effective selection of concept detectors than eight other existing ontology measures. OS <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> , in particular, is better in providing a viable and reasonable solution for fusion of multiple concept detectors.
The deformographic storage display tube (1968)

Employing a novel electrostatic configuration, the Deformographic Storage Display Tube (DSDT) incorporates the fast point-by-point light-valve capability of the Eidorphor® technique and the two-sealed-chamber construction of the Electrostatic Storage Display Tube, an earlier IBM development. In the DSDT, a thin mica diaphragm stores the charges written by the electron gun, while the resultant electrostatic field deforms a transparent dielectric elastomer film cast on its other surface (in the second chamber). The optical phase-image thus created is converted by a separate light-source and schlieren optics into a large-screen projected image, which has high contrast, and brightness. The DSDT technique permits selective erasure and update, or erasure by flood-beam. Variable persistence provides image-storage from 20 hrs. or more down to an erase-time of 15 ms. The latter, in conjunction with 15 ms develop-time, is equivalent to TV frame-speed. Spot-size of 2.5 mils has been measured, with the expected limit around 1.5 mils. Sensitivity of <10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-7</sup> coulombs/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> for writing permits recording at TV scan-speed.
eIF4B, eIF4G and RNA regulate eIF4A activity in translation initiation by modulating the eIF4A conformational cycle (2014)

Eukaryotic translation initiation factor eIF4A is a DEAD-box helicase that resolves secondary structure elements in the 5'-UTR of mRNAs during ribosome scanning. Its RNA-stimulated ATPase and ATP-dependent helicase activities are enhanced by other translation initiation factors, but the underlying mechanisms are unclear. DEAD-box proteins alternate between open and closed conformations during RNA unwinding. The transition to the closed conformation is linked to duplex destabilization. eIF4A is a special DEAD-box protein that can adopt three different conformations, an open state in the absence of ligands, a half-open state stabilized by the translation initiation factor eIF4G and a closed state in the presence of eIF4G and eIF4B. We show here that eIF4A alone does not measurably sample the closed conformation. The translation initiation factors eIF4B and eIF4G accelerate the eIF4A conformational cycle. eIF4G increases the rate of closing more than the opening rate, and eIF4B selectively increases the closing rate. Strikingly, the rate constants and the effect of eIF4B are different for different RNAs, and are related to the presence of single-stranded regions. Modulating the kinetics of the eIF4A conformational cycle is thus central for the multi-layered regulation of its activity, and for its role as a regulatory hub in translation initiation.
Image Processing by Using Fine Motion of Visual Sensor. (1995)

This paper describes a new vision image processing method by using an active sensing with fine camera motion. This algorithm obtains the hint from tremor. Tremor is one of human visual cognitive mechanism and active sensing. The algorithm can make resolution enhance more than a pixel. A photo diode is used as a visual sensor. It takes images, moving vertically and horizontally by stepping motors. Taken image data and movement data are processed by mathematical model for image restoration. As the result, resolution is enhanced more than a pixel. The mathematical model, the developed system configuration and experimental results by using the system are reported in this paper.
Mesoporous SiO<sub>2</sub>-Supported Pt Nanoparticles for Catalytic Application (2013)

SiO 2 nanoparticles have been synthesized by combining Stober’s method and nonsurfactant process. The diameters and pore sizes can be controlled by altering the template and its concentration. Mesoporous SiO 2 obtained this way has extremely large surface area compared with most oxide supports, which benefits the catalytic performance. Pt nanoparticles were in situ grown on and in mesoporous SiO 2 nanoparticles with low amount of the metal and high load ratio. Furthermore, we firstly developed a novel route, called “one-pot” method, to prepare Pt/SiO 2 catalyst where mesoporous silica preparing and Pt loading occurred in one step. This method is more efficient in saving reagent, since it can prevent Pt loss. In the meantime, it enables the template to reduce agent. The catalytic activity of Pt/SiO 2 samples was measured by CO oxidation. It is indicated that the supporting silica with mesopores is more active than silica with micropores.
Simplified Staging for Hepatocellular Carcinoma (2002)

PURPOSE: The current American Joint Committee on Cancer (AJCC) staging system for hepatocellular carcinoma (HCC) fails to stratify patients adequately with respect to prognosis. PATIENTS AND METHODS: The ability of the currently proposed tumor (T) categories to effectively stratify the survival of 557 patients who underwent complete resection for HCC at four centers was examined. Independent predictors of survival were combined into a new staging system. RESULTS: Using the current AJCC T classification, patients with T1 and T2 tumors had similar 5-year survivals (P = .6). In addition, the survival of patients with multiple bilobar tumors (T4) matched that of T3 patients (P = .5). Independent predictors of death were major vascular invasion (P < .001), microvascular invasion (P = .001), severe fibrosis/cirrhosis of the host liver (P = .001), multiple tumors (P = .007), and tumor size greater than 5 cm (P = .01). Based on our results, a simplified stratification is proposed: (a) patients with a single tumor and no microvascular invasion, (b) patients with a single tumor and microvascular invasion or multiple tumors, none more than 5 cm, and (c) patients with either multiple tumors, any more than 5 cm, or tumor with major vascular invasion (P < .001). Severe fibrosis/cirrhosis had a negative impact on survival within all categories. The survival of patients with lymph node involvement matched that of patients with major vascular invasion (P = .3). CONCLUSION: The current AJCC staging system for HCC is unnecessarily complex. We propose a simplified model of stratification that is based on vascular invasion, tumor number, and tumor size and incorporates the effect of fibrosis on survival.
The Reaction between Hydrogen Sulfide and Spherical Pellets of Zinc Oxide (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Reaction between Hydrogen Sulfide and Spherical Pellets of Zinc OxideJames B. Gibson III and Douglas P. HarrisonCite this: Ind. Eng. Chem. Process Des. Dev. 1980, 19, 2, 231–237Publication Date (Print):April 1, 1980Publication History Published online1 May 2002Published inissue 1 April 1980https://doi.org/10.1021/i260074a005Request reuse permissionsArticle Views1423Altmetric-Citations87LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (3 MB) Get e-Alerts
Synthesis and properties of a novel molecular beacon containing a benzene-phosphate backbone at its stem moiety (2009)

This paper describes the synthesis and properties of a novel molecular beacon (MB) containing a benzene-phosphate backbone at its stem moiety. The fluorescence intensity of MBs was found to stabilize by the introduction of the benzene-phosphate backbone at its stem moiety. Furthermore, an MB containing the benzene-phosphate backbone was more resistant to DNase I (endonuclease) than an MB comprising natural DNA and 2'-O-methyl-RNA. These results indicate that the MB with the benzene-phosphate backbone is superior as a molecular beacon as compared to the MB composed of natural DNA and 2'-O-methyl-RNA.
Less is More: Membrane Protein Digestion Beyond Urea–Trypsin Solution for Next-level Proteomics (2015)

The goal of next-level bottom-up membrane proteomics is protein function investigation, via high-coverage high-throughput peptide-centric quantitation of expression, modifications and dynamic structures at systems scale. Yet efficient digestion of mammalian membrane proteins presents a daunting barrier, and prevalent day-long urea-trypsin in-solution digestion proved insufficient to reach this goal. Many efforts contributed incremental advances over past years, but involved protein denaturation that disconnected measurement from functional states. Beyond denaturation, the recent discovery of structure/proteomics omni-compatible detergent n-dodecyl-β-d-maltopyranoside, combined with pepsin and PNGase F columns, enabled breakthroughs in membrane protein digestion: a 2010 DDM-low-TCEP (DLT) method for H/D-exchange (HDX) using human G protein-coupled receptor, and a 2015 flow/detergent-facilitated protease and de-PTM digestions (FDD) for integrative deep sequencing and quantitation using full-length human ion channel complex. Distinguishing protein solubilization from denaturation, protease digestion reliability from theoretical specificity, and reduction from alkylation, these methods shifted day(s)-long paradigms into minutes, and afforded fully automatable (HDX)-protein-peptide-(tandem mass tag)-HPLC pipelines to instantly measure functional proteins at deep coverage, high peptide reproducibility, low artifacts and minimal leakage. Promoting-not destroying-structures and activities harnessed membrane proteins for the next-level streamlined functional proteomics. This review analyzes recent advances in membrane protein digestion methods and highlights critical discoveries for future proteomics.
Design and implementation of a cloud computing service for finite element analysis (2012)

This paper presents an end-to-end discussion on the technical issues related to the design and implementation of a new cloud computing service for finite element analysis (FEA). The focus is specifically on performance characterization of linear and nonlinear mechanical structural analysis workloads over multi-core and multi-node computing resources. We first analyze and observe that accurate job characterization, tuning of multi-threading parameters and effective multi-core/node scheduling are critical for service performance. We design a “smart” scheduler that can dynamically select some of the required parameters, partition the load and schedule it in a resource-aware manner. We can achieve up to 7.53× performance improvement over an aggressive scheduler using mixed FEA loads. We also discuss critical issues related to the data privacy, security, accounting, and portability of the cloud service.
Far-infrared spectroscopy on oriented films of dry and hydrated DNA (1986)

Far-infrared measurements, between 3 and 450 ${\mathrm{cm}}^{\mathrm{\ensuremath{-}}1}$, of absorption spectra of highly oriented films of Li-DNA and Na-DNA in the temperature range 5--300 K are reported. Five low-frequency infrared-active vibrational modes are observed. The lowest infrared-active mode at 45 ${\mathrm{cm}}^{\mathrm{\ensuremath{-}}1}$ for Li-DNA and 41 ${\mathrm{cm}}^{\mathrm{\ensuremath{-}}1}$ for Na-DNA, as observed for the first time, is found to soften upon sample hydration. Studies of the hydration-induced absorption at the low-frequency end of the spectrum also show a pronounced absorption band at about 10 ${\mathrm{cm}}^{\mathrm{\ensuremath{-}}1}$ that is attributed to relaxation processes. Based on a simple lattice-dynamics model, the description of low-lying vibrational modes of DNA is presented. Eigenvectors of the lowest infrared-active and Raman-active modes are calculated. In addition, the model semiquantitatively describes the influence of hydration on mode frequencies.