gebhart/patrepeval huggingface dataset:
The modulation of granulomatous tissue and tumour angiogenesis by diclofenac in combination with hyaluronan (HYAL EX-0001). (1995)

In a novel application, hyaluronan has been utilized as a delivery system for topical and i.v. therapeutics. Clinical trials and case reports show that topical diclofenac delivered in hyaluronan (HYAL CT-1101) is effective against basal-cell carcinoma and actinic keratosis. The effect of this drug formulation on tumour growth and angiogenesis, as well as granulomatous tissue angiogenesis, has been investigated experimentally. The evidence that hyaluronan has a permissive effect on the inhibition of granulomatous tissue angiogenesis by diclofenac (as assessed by the carminel/gelatin vascular casting method) when injected into the lesion or applied topically is reviewed. Topical diclofenac in hyaluronan also induces a regression of the existing neo-vasculature of granulomatous tissue when applied therapeutically. The diclofenac formulated in hyaluronan was also found to be profoundly effective against the development of subcutaneous Colon-26 tumours in syngeneic balb/c mice (T/C ratio after 12 days topical application of 0.174, p < 0.0001). Analysis of the tumour vasculature showed that vascular development was retarded by 12 days. This was shown by the reduction in the tumour density of carmine in the vascular casts, as well as reduced blood-vessel density visualized by rat anti-mouse CD31 immunohistology. Hyaluronan alone had a significant effect on tumour development with a 50% inhibition of tumour growth and only a transient reduction in vascularity. The effects noted when diclofenac is formulated in hyaluronan, and applied topically, could be related to trans-dermal delivery and deposition properties of hyaluronan, and to the binding properties of hyaluronan to areas of pathology with high expression of hyaluronan receptors such as RHAMM, ICAM-1, and CD44.
Operation of the liquid-metal heat pipe in applications involving aerodynamic heating (1996)

As part of a US Army missile development program, liquid-metal heat pipes have been investigated to remove the heat flux associated with the missile fins being located in hot exhaust gas paths. Using steady-state and transient analyses, a solution method has been developed to identify the required length of the condenser for a design operation when the heat pipe is coupled with aerodynamic heating and cooling environments. A simple transient analysis using the lumped heat-capacity method predicts the response of operating temperatures and the propagation of the continuum front when the liquid-metal heat pipe is started from the frozen state.
Downlink Performance Analysis of Distributed Antenna Systems with Linear Precoding (2015)

Distributed antenna system (DAS) has emerged as a promising architecture for future mobile communications. Compared with collocated antenna system (CAS), DAS has advantages in reducing transmission power and improving the cell coverage area. In this paper, the downlink performance of DAS with linear precoding is analyzed. The optimization problem of minimizing the total transmitted power while satisfying signal-to-interference-and-noise ratio (SINR) constraints is studied to optimize the beamforming for all user jointly, which can be solved by conic optimization method. However, the problem is non-convex and can not be solved efficiently. Suboptimal methods are proposed by optimizing power allocation after given the direction of precoding. In simulation, the performance of different linear precoding methods are analyzed for the downlink of DAS. Moreover, the performance of DAS and CAS are also compared with the same antenna configuration and direction of precoding. It is shown that compared with CAS, DAS achieves the same performance with much less transmission power.
Oxidation of Raloxifene to Quinoids:  Potential Toxic Pathways via a Diquinone Methide and <i>o</i>-Quinones (2004)

Raloxifene was approved in 1997 by the FDA for the treatment of osteoporosis in postmenopausal women, and it is currently in clinical trials for the chemoprevention of breast cancer. Before widespread use as a chemopreventive agent in healthy women, the potential cytotoxic mechanisms of raloxifene should be investigated. In the current study, raloxifene was incubated with GSH and either rat or human liver microsomes, and the metabolites and GSH conjugates were characterized using liquid chromatography-tandem mass spectrometry. Raloxifene was converted to raloxifene diquinone methide GSH conjugates, raloxifene o-quinone GSH conjugates, and raloxifene catechols. For comparison, three raloxifene catechols were synthesized and characterized. In particular, 7-hydroxyraloxifene was found to oxidize to the 6,7-o-quinone. As compared with raloxifene diquinone methide, which has a half-life of less than 1 s in phosphate buffer, the half-life of raloxifene 6,7-o-quinone was much longer at t(1/2) = 69 +/- 2.5 min. The stability offered by raloxifene 6,7-o-quinone implies that it may be more toxic than raloxifene diquinone methide. Cytotoxicity studies in the human breast cancer cell lines S30 and MDA-MB-231 showed that 7-hydroxyraloxifene was more toxic than raloxifene in both cell lines. These results suggest that raloxifene could be metabolized to electrophilic and redox active quinoids, which have the potential to cause toxicity in vivo.
Accurate Detection of Demosaicing Regularity for Digital Image Forensics (2009)

In this paper, we propose a novel accurate detection framework of demosaicing regularity from different source images. The proposed framework first reversely classifies the demosaiced samples into several categories and then estimates the underlying demosaicing formulas for each category based on partial second-order derivative correlation models, which detect both the intrachannel and the cross-channel demosaicing correlation. An expectation-maximization reverse classification scheme is used to iteratively resolve the ambiguous demosaicing axes in order to best reveal the implicit grouping adopted by the underlying demosaicing algorithm. Comparison results based on syntactic images show that our proposed formulation significantly improves the accuracy of the regenerated demosaiced samples from the sensor samples for a large number of diversified demosaicing algorithms. By running sequential forward feature selection, our reduced feature sets used in conjunction with the probabilistic support vector machine classifier achieve superior performance in identifying 16 demosaicing algorithms in the presence of common camera post demosaicing processing. When applied to real applications, including camera model and RAW-tool identification, our selected features achieve nearly perfect classification performances based on large sets of cropped image blocks.
Can opiates relieve neuropathic pain? (1988)

Box 0114, Department of Neurology, University of California San Francisco, San Francisco, CA 94143 U.S.A.
Polymer optical interconnects for PCB (2001)

Fraunhofer IZM has developed a packaging concept, which is based on a hybrid carrier, containing both electrical and optical interconnects: the Electrical Optical Circuit Board (EOCB). The key element is an additional optical layer with multimode waveguide structures. This layer is handled by standard PCB technology. As a result, the waveguides are completely incorporated into the circuit board. We used the hot embossing process for the first test of effective foil-structuring. After filling the core of the waveguides and sealing them with an over-cladding, the optical layer is given into the PCB process. Furthermore, waveguide structuring by photolithographic patterning is also a promising way to incorporate waveguide structures into the circuit board and is currently under test. The choice of appropriate polymer materials is a key problem when applying these techniques. They have to be compatible with the structuring and laminating processes and display excellent optical properties. We focus on recent results showing the optical characteristics of laminated polymer waveguides made by hot embossing and of waveguides made by photolithography.
To See or not to See: The Need for Attention to Perceive Changes in Scenes (1997)

When looking at a scene, observers feel that they see its entire structure in great detail and can immediately notice any changes in it However, when brief blank fields are placed between alternating displays of an original and a modified scene, a striking failure of perception is induced Identification of changes becomes extremely difficult, even when changes are large and made repeatedly Identification is much faster when a verbal cue is provided showing that poor visibility is not the cause of this difficulty Identification is also faster for objects considered to be important in the scene These results support the idea that observers never form a complete, detailed representation of their surroundings In addition, the results indicate that attention is required to perceive change, and that in the absence of localized motion signals attention is guided on the basis of high-level interest
Efficient processing of SPARQL joins in memory by dynamically restricting triple patterns (2009)

Since there are a lot of similar or common properties between RDF and relational databases and between SPARQL and SQL, many efforts focus on leveraging the research results of optimizing relational query languages for optimizing SPARQL queries. However, SPARQL has its own characteristics different from SQL, which are not fully exploited by existing work. Therefore, there is still much space for research on optimizing SPARQL queries. Based on the triple nature of RDF data, we create 7 indices to retrieve RDF data quickly; based on the SPARQL-specific properties and the 7 indices, we develop a new, efficient approach to computing join by dynamically restricting triple patterns. Our experimental results show the efficiency of our approach.
HYDROLYSIS AND HYDRAZINOLYSIS OF ESTERS OF N,N-DIMETHYLDITHIOCARBAMIC ACID: A METHOD FOR THE PREPARATION OF MERCAPTANS (1956)

A method has been developed for the preparation of mercaptans from alkyl and aralkyl chlorides. This consists of the condensation of sodium N,N-dimethyl-dithiocarbamate with halides followed by alkaline hydrolysis or hydrazinolysis of the resulting N,N-dimethyldithiocarbamates (IV). In the hydrazinolysis of IV, an insoluble solid by-product was formed which was identified as 3-hydrazino-4-amino-5-mercapto-4,1,2-triazole. Although this method was found to have wide scope a few failures were encountered. Nitro-derivatives of IV were sensitive to alkali or hydrazine and yielded only tars on attempted degradation. β-Phenoxyethyl N,N-dimethyldithiocarbamates (IX) were found to possess a labile alkyl–oxygen bond so that in the presence of alkali or hydrazine only the corresponding phenols were formed. The labile nature of the alkyl–oxygen bond ceased abruptly when the alkyl chain of IX was increased so that 3-p-chlorophenoxypropyl and 4-p-chlorophenoxybutyl mercaptans could be prepared in high yields.
METHOD FOR IDENTIFYING SPECIFIC VEHICLES BY MATCHING TV IMAGE PATTERNS (1998)

As for the methods for identifying specific vehicles, a technique for reading the unique identification numbers or letters that are displayed on the vehicles is already put into practical use. However, such a method requires complex hardware and software, making it impractical when a simple vehicle detection device is needed for traffic signal control or regulation. Furthermore, it poses the problem of being unable to accommodate the identification of signs and marks. As a method for resolving these problems, this paper describes a technique, which has been proposed and put to practical use, for identifying vehicles by obtaining the correlation value between the images of the vehicle that pass through a surveillance point (which are fed continuously by a television camera that is installed above the vehicle lane) in relation to a previously created reference template image that represents the characteristics of a specific vehicle. For the covering abstract see IRRD E102946.
Expansion and Transduction of Nonenriched Human Cord Blood Cells Using HS-5 Conditioned Medium and FLT3-L (2000)

Cord blood (CB) stem cell transplantations have been associated with delayed hematopoietic engraftment. This has most likely been due to the limited numbers of hematopoietic short-term repopulating cells in CB. Ex vivo expansion of CB has been attempted, and expansion of CD34-enriched CB has been successful; however, CD34 enrichment procedures are in general associated with substantial cell loss. Thus, we have studied culture conditions for expansion of nonenriched CB. Nonenriched CB cells were cultured for 21 days in the presence of conditioned medium from the HS-5 stromal cell line and FLT3-L or alternatively in the presence of FLT3-L, stem cell factor (SCF), megakaryocite growth and development factor (MGDF), and granulocyte colony-stimulating factor (G-CSF) (FSMG), either on fibronectin fragment CH-296-coated dishes or on uncoated dishes. With all four culture conditions, the number of mononuclear cells initially decreased until day 7 and then increased until the end of the expansion cultures. Overall expansion using HS-5 and FLT3-L resulted in superior expansion of MNC and CFU-C (44-/34-fold) for both cultures with and without CH-296 compared to FSMG (18-/17-fold). Expansion on CH-296 was less efficient than expansion on tissue culture-treated wells without CH-296 for both conditions. We then studied the best time for transduction on nonenriched CB. In contrast to enriched CD34 cells, we found for both conditions, HS-5/FLT3-L and growth factor cocktail, higher transduction efficiencies when cells were transduced on day 7 as compared to day 2. Gene transfer rates up to 45% were achieved with both conditions, which corresponded with the increased number of cells in S phase on day 7 compared to day 2. We conclude that HS-5 and FLT-3L allow efficient expansion and transduction of nonenriched CB.
Optical RF communications adjunct: Coming of age (2009)

The concept of Free Space Optical (FSO) communications has been around since the late 1960's.This paper will describe some recent experimental results that demonstrate and validate hybrid FSO/RF communication links as viable components in a tactical high data rate network. In particular, we will describe air-mountain link closure up to ranges of 200 km under heavy atmospheric turbulence. These links were operated at low packet and bit error rates, with occasional link outages. Like the internet, we used retransmission to minimize the effect of these outages on link throughput. For example, when the FSO system is running, ORCA uses the RF system for retransmission to improve link efficiency. In addition, we will discuss potential losses created by the aircraft aero-optics effects. Finally, we will show comparison between model predictions and experimental data that suggest we can predict link performance if the atmospheric turbulence conditions are known.
ChemInform Abstract: Reaction of 2‐Aminobenzohydrazides with Schiff Bases. A New Route to 3‐Benzylideneamino‐4(3H)‐quinazolinones and 2‐[2‐(Methylamino)‐phenyl]‐5‐aryl‐1,3,4‐oxadiazoles. (1986)

Abstract Reaction of 2‐aminobenzohydrazide (I) with the Schiff bases (II) yields the bis‐arylidene derivatives (III) which cyclize to give the quinazolinones (IV) on treatment with KMnO 4 .
The Type 2 Capsule Locus of <i>Streptococcus pneumoniae</i> (1999)

The type 2 capsule locus of Streptococcus pneumoniae was characterized in Avery's strain D39, which is the parent strain of the standard transformation recipients currently used in pneumococcal research and is largely used as a virulent strain in studies on the pathogenesis of pneumococcal infections. The capsule locus was sequenced by using a 21.7-kb PCR fragment from the D39 genome as a template. Sequence data analysis showed the presence of 18 open reading frames, 17 of which have the same direction of transcription and all of which are potentially involved in capsule biosynthesis. It was also shown that R36A and R6, which are unencapsulated (rough) derivatives of D39, carry a 7,504-bp deletion involving nine capsule genes.
Machine Learning for Network Automation: Overview, Architecture, and Applications [Invited Tutorial] (2018)

Networks are complex interacting systems involving cloud operations, core and metro transport, and mobile connectivity all the way to video streaming and similar user applications. With localized and highly engineered operational tools, it is typical of these networks to take days to weeks for any changes, upgrades, or service deployments to take effect. Machine learning, a sub-domain of artificial intelligence, is highly suitable for complex system representation. In this tutorial paper, we review several machine learning concepts tailored to the optical networking industry and discuss algorithm choices, data and model management strategies, and integration into existing network control and management tools. We then describe four networking case studies in detail, covering predictive maintenance, virtual network topology management, capacity optimization, and optical spectral analysis.
Performance improvement of closed-loop power control in CDMA cellular mobile communication systems (2002)

The impairments in the current closed-loop power control for the reverse link of the IS-95 CDMA system are investigated, and an improved scheme is proposed using linear prediction and multi-step power control at the mobile station. This method does not require a modification of the mobile and base station air interface standard. The correlation property of the accumulated power control signals is briefly discussed. Simulations conducted for the reverse link have shown that by improving the performance of the closed-loop power control, the reverse link overall performance is improved considerably.
Policy based virtualised security architecture for SDN/NFV enabled 5G access networks (2016)

The challenging traits of 5G networks to support novel and diverse business requirements of vertical sectors have rendered current network security approaches impotent. To address various security requirements of 5G networks and services, a holistic and robust security architecture mindful of 5G technical and business features becomes vital. This paper describes a holistic security architecture for a multi-tenant NFV/SDN enabled 5G access network based on policy-based security management and monitoring & smart analytics.
Problems and Prospects in the Mexican and Borderlands Economies (1991)

Book Review| July 01 1991 Problems and Prospects in the Mexican and Borderlands Economies Transnational Corporations versus the State: The Political Economy of the Mexican Auto IndustryDouglas C. BennettKenneth E. SharpeEconomic Policymaking in Mexico: Factors Underlying the 1982 CrisisRobert E. LooneyThe Border Economy: Regional Development in the SouthwestNiles Hansen Jeffrey Bortz Jeffrey Bortz Search for other works by this author on: This Site PubMed Google Scholar Mexican Studies/Estudios Mexicanos (1991) 7 (2): 303–317. https://doi.org/10.2307/1052068 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Jeffrey Bortz; Problems and Prospects in the Mexican and Borderlands Economies. Mexican Studies/Estudios Mexicanos 1 July 1991; 7 (2): 303–317. doi: https://doi.org/10.2307/1052068 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search nav search search input Search input auto suggest search filter All ContentMexican Studies/Estudios Mexicanos Search This content is only available via PDF. Copyright 1991 Regents of the University of California Article PDF first page preview Close Modal You do not currently have access to this content.
In vitro antimicrobial activity of five essential oils on multi-drug resistant Gram-negative clinical isolates (2016)

The antimicrobial activities of the essential oils are influenced by the strain origin (wild, reference, drug sensitive, or resistant) and it should be taken into consideration whenever investigating the plants' potential for developing new antimicrobials.
The data encryption standard in perspective (1978)

The Data Encryption Standard (DES) was approved as a Federal Information Processing Standard (FIPS) by the Secretary of Commerce on November 23, 1976. This Standard was developed as a part of the Computer Security Program within the Institute for Computer Sciences and Technology at the National Bureau of Standards (NBS). This paper places this standard in perspective with other computer security measures that can and should be applied to Federal computer systems either before or coincident to using the Data Encryption Standard. In 1972, NBS initiated the standards development effort leading to adoption of the DES. During this period, NBS solicited for algorithms and information upon which a standard could be based, published for comment the algorithm which best satisfied the requirements of an encryption standard, and coordinated the effort with both the potential using communities and supplying communities. This paper outlines the environment surrounding and the history of the Data Encryption Standard and discusses the objectives of additional standards to be developed within the computer security program.
Editorial (2010)

It was indeed very heartening to see the enthusiasm generated in the National Welding Meet recently held in Pondichery in August. This was the first occasion perhaps, that such event was organized in an off-branch location. As many as 40 papers were presented in 2 parallel sessions and the participation of delegates from the surrounding industry was also very encouraging. But what delighted me more was the frequent enquiries coming from young engineers and technologists willing to contribute papers sharing their experience and research work in the IWJ. Many delegates also expressed happiness about the technical content of the journal including the very useful AWS section.
An interface to support lazy replicated file service (2003)

The authors argue that, if they are going to assume low-sharing workloads, then it is possible to build more efficient implementations that provide the same (or stronger) semantics by making fullest use of the assumption. Accordingly, they take an extreme point on the spreading/searching tradeoff: the searcher is made responsible for all the work. Thus, spreading can be made asynchronous and hence very fast from the caller's viewpoint. They employ an important optimization to eliminate most of the searching work when there is little sharing. Their technique carries other advantages as well: simple and flexible recovery algorithms, and suitability for mobile computing.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Soft decision approaches for blind adaptive decision feedback equalizers (2003)

We consider joint blind optimization schemes for decision feedback equalizer (DFE) coefficients and decision device, and propose adaptive solutions based on a soft decision device which combines a blind infinite impulse response (IIR) filtering adaptation and the conventional decision directed (DD) DFE adaptation. The benefits of our approach are mainly three-fold: (1) the initialization of DFE taps does not rely on a training sequence; (2) the transition between the (re)initialization period and the tracking period is continuous and consequently the equalizer exhibits robust performance under sudden time variation in the multipath channel; (3) the optimized soft decision device mitigates error propagation of the DFE and further reduces the mean square error (MSE) of the DFE.