9-(1,3-dihydroxy-2-propoxymethyl)guanine for Cytomegalovirus Infections in Patients with the Acquired Immunodeficiency Syndrome (1985)

Brief Reports1 September 19859-(1,3-dihydroxy-2-propoxymethyl)guanine for Cytomegalovirus Infections in Patients with the Acquired Immunodeficiency SyndromeMICHAEL C. BACH, M.D., SANDRA P. BAGWELL, M.D., NANCY P. KNAPP, M.D., KENT M. DAVIS, M.D., PETER S. HEDSTROM, M.D.MICHAEL C. BACH, M.D.Search for more papers by this author, SANDRA P. BAGWELL, M.D.Search for more papers by this author, NANCY P. KNAPP, M.D.Search for more papers by this author, KENT M. DAVIS, M.D.Search for more papers by this author, PETER S. HEDSTROM, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-103-3-381 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDisseminated cytomegalovirus infection is a major cause of mortality in patients with the acquired immuno-deficiency syndrome (1) as well as in other immunosuppressed patients including bone marrow transplant recipients (2). We have had recent positive results with the use of 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG), a new nucleoside antiviral agent, in halting progressive hemorrhagic retinitis and symptomatic pneumonitis due to cytomegalovirus. We report our experience with DHPG in three patients with the acquired immunodeficiency syndrome.Patient 1:A 31-year-old man was diagnosed as having the acquired immunodeficiency syndrome in November 1983 when he developedPneumocystis cariniipneumonia. In June 1984 he developed a...References1. QUINNANMASURROOK GHA. Herpesvirus infections in the acquired immunodeficiency syndrome. JAMA. 1984;252:72-7. CrossrefMedlineGoogle Scholar2. MEYERSSPENCERWATTS JHJ. Cytomegalovirus pneumonia after human marrow transplantation. Ann Intern Med. 1975;82:181-8. LinkGoogle Scholar3. RASMUSSENCHENMULLENAXMERIGAN LPJT. Inhibition of human cytomegalovirus replication by 9-(1,3-dihydroxy-2-propoxymethyl)guanine alone and in combination with human interferons. Antimicrob Agents Chemother. 1984;26:441-5. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. 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CLOTET, M.D., M. GRIFOL, M.D., J. BOIX, M.D., J. JUNCA, M.D., M. FOZ, M.D., M. RIBAS, M.D.Breakthrough of Cytomegalovirus Infection Despite 9-(1,3-Dihydroxy-2-propoxymethyl)guanine TherapyMICHAEL C. BACH, M.D.Treatment of Serious Cytomegalovirus Infections with 9-(1,3-Dihydroxy-2-Propoxymethyl)Guanine in Patients with AIDS and Other ImmunodeficienciesEffect of 9-(1,3-Dihydroxy-2-Propoxymethyl) Guanine on Serious Cytomegalovirus Disease in Eight Immunosuppressed Homosexual MenHENRY MASUR, M.D., H. CLIFFORD LANE, M.D., ALAN PALESTINE, M.D., PHILLIP D. SMITH, M.D., JODY MANISCHEWITZ, M.D., GARTH STEVENS, M.D., LESLIE FUJIKAWA, M.D., ABE M. MACHER, M.D., ROBERT NUSSENBLATT, M.D., BARBARA BAIRD, R.N., MARGARET MEGILL, R.N., ALEC WITTEK, M.D., GERALD V. QUINNAN, M.D., JOSEPH E. PARRILLO, M.D., ALAIN H. ROOK, M.D., LAWRENCE J. ERON, M.D., DONALD M. PORETZ, M.D., ROBIN I. GOLDENBERG, M.D., ANTHONY S. FAUCI, M.D., EDWARD P. GELMANN, M.D.Prophylactic use of immunoglobulin in bone marrow transplantationFoscarnet for Cytomegalovirus RetinitisD. R. J. SINGER, M.R.C.P., T. J. FALLON, M.B., Ch.B., W. E. SCHULENBURG, F.R.C.S., G. WILLIAMS, F.R.C.S., J. COHEN, M.SC., M.R.C.P.Chemotherapy of herpesvirus infections: Present successes and future hopes 1 September 1985Volume 103, Issue 3Page: 381-382KeywordsAIDSCytomegalovirus infectionMortalityNucleosidesPatientsPneumocystis carinii pneumoniaPneumonitisResearch laboratoriesRetinitisVirology Issue Published: 1 September 1985 PDF downloadLoading ...