gebhart/patrepeval huggingface dataset:
Dynamic changes in cytokine levels in serum and synovial fluid following filtration leukocytapheresis therapy in patients with rheumatoid arthritis (2001)

We attempted to determine whether various cytokine levels in the serum and synovial fluid (SF) of rheumatoid arthritis (RA) patients are influenced by the performance of filtration leukocytapheresis (LCP). The filtration LCP procedure that used a Cellsorba column (LCP group: n=22; responder subgroup: n=17, non-responder subgroup: n=5) or sham apheresis (control group; n=7) was repeated three times at 1-week intervals. Serum (LCP group, n=22; control group, n=7) and SF (LCP group, n=6; control group, n=3) samples were collected before and after LCP. Levels of tumor necrosis factor alpha (TNFalpha), interleukins (IL-1 beta, IL-2, IL-6, IL-8, IL-10, and IL-15), granulocyte-macrophage colony-stimulating factor (GM-CSF), monocyte chemoattractant protein-1 (MCP-1), RANTES were measured by an enzyme-linked immunosorbent assay. Serum TNF alpha, IL-15, and RANTES were significantly reduced only in the LCP group. Serum IL-10 significantly increased only in the LCP group. In the LCP subgroup, serum IL-15, GM-CSF, and RANTES levels were reduced significantly, while serum IL-10 levels increased significantly only in the responder group after treatment. Serum TNF alpha levels were reduced significantly in both subgroups. Changes in serum IL-10 correlated positively with the improvement of patient's assessment of pain and global severity, and physician's assessment of global severity. These results indicate that the removal of leukocytes from the peripheral blood of RA patients provokes dynamic changes in some cytokine levels in the serum and/or synovial fluid. These changes may explain some of the mechanisms by which the articular symptoms are improved by filtration LCP.
An Efficient, Facile, and General Synthesis of 1<i>H</i>‐Indazoles by 1,3‐Dipolar Cycloaddition of Arynes with Diazomethane Derivatives (2007)

Take your pick: Both N-unsubstituted and 1-aryl 1H-indazoles are available in good to high yields through the [3+2] cycloaddition of benzynes derived from o-silylaryl triflates with diazomethane derivatives (see scheme). In the presence of KF/[18]crown-6, the N-unsubstituted 1H-indazole is formed, whereas the 1-arylated product is obtained regioselectively with CsF and an excess of the triflate. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z700101_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Circuits on cellulose (2013)

You wake up with a heavy head. Was it the half dozen glasses of champagne last night or are you getting sick? In your bathroom is a little strip of paper that can tell you for sure. You place it on your tongue and after a few seconds, you pull it back to see the bad news: There's a small green dot next to the word "flu." When you fish your doctor's business card out of your wallet, you notice it looks different from the last time you looked at it. The phone number for his office was originally black. Now it's displayed in blinking red letters, a sign that the number was changed recently. The electronics in this scenario are not far off; in fact the basic technological breakthroughs needed to make them work have all been achieved in the past few years. At the moment the costs are still too high for them to be used in things like business cards or package labels, but remarkable advances in materials science and simpler fabrication methods are setting the stage for a whole new breed of cheap, bendable, disposable, and perhaps even recyclable electronics. And some of the most exciting work in this field is happening with paper.
Image‐Predicated Sorting of Adherent Cells Using Photopatterned Hydrogels (2012)

Using photopatterned hydrogels and selective cell encapsulation, populations of adherent cells are examined using microscopy and sorted into viable sub-populations predicated on their imaged phenotypes. The inexpensive method utilizes commercial reagents and equipment available in many labs, making image-predicated cell sorting an accessible technique for a large number of individual labs.
Multi-Image Stitching and Scene Reconstruction for Evaluating Change Evolution in Structures (2011)

It is well-recognized that civil infrastructure monitoring approaches that rely on visual approaches will continue to be an important methodology for condition assessment of such systems. Current inspection standards for structures such as bridges require an inspector to travel to a target structure site and visually assess the structure's condition. This study presents and evaluates the underlying technical elements for the development of an integrated inspection software tool that is based on the use of commercially available digital cameras. For this purpose, digital cameras are appropriately mounted on a structure (e.g., a bridge) and can zoom or rotate in three directions. They are remotely controlled by an inspector, which allows the visual assessment of the structure's condition by looking at images captured by the cameras. By not having to travel to the structure's site, other issues related to safety considerations and traffic detouring are consequently bypassed. The proposed system gives an inspector the ability to compare the current (visual) situation of a structure with its former condition. If an inspector notices a defect in the current view, he/she can request a reconstruction of the same view using images that were previously captured and automatically stored in a database. Furthermore, by generating databases that consist of periodically captured images of a structure, the proposed system allows an inspector to evaluate the evolution of changes by simultaneously comparing the structure's condition at different time periods. Several illustrative examples are presented in the paper to demonstrate the capabilities, as well as the limitations, of the proposed vision-based inspection procedure.
Jilotepec en los mitos del Bajío (1997)

En la recomposicion de las sociedades indigenas bajo el gobierno novohispano fue fundamental su sentido territorial, ya que actuo como nucleo integrador y cohesionador de la nueva identidad comunitaria. Las tierras de la comunidad quedaron circunscritas dentro de una demarcacion senalada y aceptada por el nuevo orden, lo que tambien fue asi reconocido por quienes habitaban en su colindancia. Este territorio se constituyo en una entidad politica -donde la comunidad llevo a cabo sus actividades economicas y sociales basicas- que a su vez persistio en ella  el caracter sagrado, impreso por la proteccion de las deidades tutelares y de sus ancestros.
Accelerating the data shuffle operations for FFT algorithms on SIMD DSPs (2011)

FFT is a key kernel of OFDM in the 3GPP-LTE system. Many researchers employ SIMD DSPs to accelerate FFT algorithms by the feature that there is about 75% SIMD workloads in them. This paper makes a detailed analysis on how to accelerate FFT algorithms on SIMD DSPs. We propose an EXC instruction for SIMD DSPs. The EXC instruction can exchange the specified elements between two vector registers in one cycle. It can achieve performance benefits ranging from 1.18× to 1.37× and reduce the dynamic code size by up to 15% compared with the vhalfup and vhalfdn instructions which are implemented in VIRAM processor. Moreover, two useful suggestions are presented in this paper for designing the architecture oriented to the 3G/4G wireless communication systems.
Semi-insulating silicon for microwave integrated circuits (2002)

In silicon many of the transition metals have states near the center of the gap and so can be used to form semi-insulating wafers. In this paper calculated and measured resistivities of silicon as a function of substrate doping for gold doped n-type and silver doped p-type silicon are presented. Arrhenius plots of the effective diffusion coefficient of gold in Si/sub 3/N/sub 4/ diffusion barriers are also measured. A structure for forming semi-insulating silicon with an upper conductive layer using a wafer bonding technique is developed.
A photon‐mode full‐color rewritable image using photochromic compounds (2004)

Abstract— A photon‐mode full‐color rewritable image has been demonstrated. Three types of photochromic fulgides having yellow, magenta, and cyan color were used as rewritable dyes. Photochromic fulgides were mixed and coated on a white polyethylene terephthalate film. Upon irradiation with three (red, green, and blue) visible light beams, a wide hue extent, a high white reflectance of over 80%, and a high contrast ratio of over 45:1 were attained. A full‐color image retains its colors for over 1 hour under standard‐office‐brightness conditions (700 lx). The photochemical coloration‐decoloration cycles could be repeated over 100 times without substantial losses.
Overview of citric acid production from <i>Aspergillus niger</i> (2015)

Citric acid has high economic potential owing to its numerous applications. It is mostly produced by microbial fermentation using Aspergillus niger. In view of surges in demand and growing markets, there is always a need for the discovery and development of better production techniques and solutions to improve production yields and the efficiency of product recovery. To support the enormous scale of production, it is necessary and important for the production process to be environmentally friendly by utilizing readily available and inexpensive agro-industrial waste products, while maintaining high production yields. This article reviews the biochemistry of citric acid formation, choices of citric-acid producing microorganisms and raw materials, fermentation strategies, the effects of various fermentation conditions, citric acid recovery options and the numerous applications of citric acid, based on information drawn from the literature over the past 10 years.
Infinite Worlds: Eighteenth-Century London, the Atlantic Ocean, and Post-Slavery in S.I. Martin's Incomparable World, Lawrence Hill's The Book of Negroes, David Dabydeen's A Harlot's Progress, and Thomas Wharton's Salamander (2013)

In Black London: Life before Emancipation (1995), Gretchen Holbrook Gerzina writes of how, on discovering that 15,000 Africans and their descendants were living in London in 1768, she was struck by a vision of her present-day London as 'suddenly occupied by two simultaneous centuries' (2) - an eighteenth-century city of black pageboys and entertainers, of black beggars and prostitutes and autobiographers, overlaying the late twentieth-century one like a ghostly palimpsest. In the same decade as Gerzina was articulating these spectral imaginings, four prominent black British novelists were similarly looking back to the eighteenth century - to the final decades of the British slave trade, to the Atlantic Ocean across and around which it took place, and to London, where the abolitionist cause was advanced. Caryl Phillips, S.I. Martin, David Dabydeen, and Fred D'Aguiar all published novels in the 1990s that have black protagonists and are set entirely or partly in the eighteenth-century metropolis. In the subsequent decade, two Canadian novelists did likewise: Lawrence Hill and Thomas Wharton both published historical novels featuring female ex-slaves that end up in London after long and circuitous oceanic journeys.[i] Since historical novels are always prompted by present-tense obsessions and therefore frequently gaze at two centuries simultaneously, how does this outpouring of eighteenth-century-oriented narrative reflect and enhance our contemporary understanding of slavery, the Atlantic world, and London? What geographies and identities, what forms of mobility and dwelling, what personal quests and local or global communities do these novels imagine for the imperial capital's black inhabitants at a time when the prevailing winds were blowing abolition and revolutionary political change across the Atlantic world? And how do these texts - transhistorical, transnational, circum-Atlantic visions of London echo - or anticipate - other postcolonial writings about the world city of our time and the black person's place in it?
철 - 질소 2 원계에서 γ＇ - Phase 의 성장에 관한 연구 (1979)

철-질소 2원계에서 중간상 질화물 γ´-Phase (Fe₄N)의 성장 기구를 규명하기 위하여 질소의 확산과정을 multiphase diffusion으로 가정하여 유도한 γ´-Phase의 성장율은 
dX_(III)/dt=(M/ρ)Fe₄N·5/4·D_(III)ΔC_(III)/X_(III) (1) 
이었고 시료에 형성된 r´phase층의 두께는 
X_(III)=[10/4[M/ρ]Fe₄N·D_(III)ΔC_(III)]^½·t½ (2)
로 표시됨을 알 수 있었다.
한편 650℃∼900℃의 온도 범위에서 순철로 된 원통형 시료를 질화처리한 후 침투된 질소의 양과 포화 질소량으로부터 산출한 질소의 확산 계수는(weighing method), 
D=1.3×10^(-2)exp[-28300/RT]㎠/sec (3)
이였고 시료에 형성된 γ´-phase층의 두께를 층정하여 (2)식에 대입하여 얻은 질소의 확산계수는 (multiphase treatment) 
D=2.9×10^(-2)exp[-27700/RT]㎠/sec (4) 
로써 이 결과는 (3)식의 결과와 잘 일치하고 있음을 알 수 있었다.
그러나 질소의 확산을 single phase diffusion으로 처리하여 얻은 결과는(single phase treatment) 
D=1.6×10^(-4)exp[-18600/RT]㎠/sec (5) 
로써 위의 두 결과와 차이가 심하며 많은 편차가 내포되어 있음을 본 연구를 통하여 알 수 있었다.
PPAR Ligands for Metabolic Disorders (2003)

As master regulators of lipid metabolism the peroxisome proliferator activated receptor (PPAR) family controls a wide variety of cellular processes, and thus it is not surprising that a large effort has focussed on discovering agents to pharmacologically modulate activity of these receptors. Early generation PPAR ligands, such as the fibrates and the thiazolidinediones (TZDs), were discovered empirically through an in vivo structure activity relationship exercise, whereas currently PPAR ligands are more often identified through target based structural design using cloned and expressed receptors. Regardless of how they were discovered, the development and clinical use of PPAR ligands throughout the last decade has greatly advanced understanding of the physiological function and therapeutic value of modulating these receptors. This review will briefly examine the PPAR family and then outline in greater detail select PPAR ligands indicated for the treatment of metabolic disorders.
Behavioral to structural translation in a bit-serial silicon compiler (1988)

After a brief discussion of previous work in the field of behavioral-to-structural translation, the bit-serial architecture which is the target of the bit-serial compiler is discussed. The bit-serial language (BSL) is then defined, and the details of the behavioral-to-structural translation are given.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Highly Enantioselective Rh-Catalyzed Hydrogenation Reactions Based on Chiral Monophosphite Ligands (2000)

Excellent ligands in the Rh-catalyzed hydrogenation of olefins (ee>95 %) are the monophosphites 1 derived from BINOL. Thus, the notion that only chelating ligands lead to high enantioselectivities in these reactions no longer pertains.
A high‐performance architecture for variable length instructions (1985)

Abstract This paper considers a high‐performance architecture for Variable Length Instructions (VLI) and its evaluation. The VLI studied here are characterized by a multioperand which can treat several independent operands, and orthogonality which can specify the operand address independently of the operation code. This architecture consists of the pipeline processing method suitable for multioperand instruction format, instruction/data separate‐type dual cache memory configuration to obtain memory throughput necessary for efficient operation of pipeline, and the operand location‐free microprogramming method with virtualized operand interface. The basic ideas of the pipeline processing method are the operand specifier (OSP) based pipeline processing which is realized by Inter‐OSP based pipeline processing and two simultaneously processing OSPs. From the mixed value analysis and the simulation result, it is clarified that this architecture makes it possible to improve the performance 1.8 times faster than without it. The additional hardware increase for this architecture is 33%.
Mineralization of Bacterial Cell Mass on a Photocatalytic Surface in Air (1998)

Whole cells deposited on a titanium dioxide-coated surface have been oxidized in air to carbon dioxide via photocatalysis. This paper provides the first evidence that the organic matter in whole cells can be completely oxidized. Three experimental techniques were employed to monitor this reaction: scanning electron microscopy,14C radioisotope labeling, and batch reactor measurements. The scanning electron microscopy experiments illustrate the disappearance of Escherichia coli cell mass. The 14C radioisotope labeling experiments establish that the carbon content of E. coli is oxidized to form carbon dioxide with substantial closure of the mass balance. The batch reactor experiments corroborate the mass balance and provide a preliminary indication of the rate of the oxidation reaction. These results provide evidence that a photocatalytic surface used for disinfection can also be self-cleaning in an air−solid system.
Primary motility disorders of the esophagus (1991)

Primary motility disorders of the esophagus , Primary motility disorders of the esophagus , کتابخانه دیجیتالی دانشگاه علوم پزشکی و خدمات درمانی شهید بهشتی
The analgesic activity of some kyotorphin-tuftsin analogs. (1991)

The analgesic potency of the C-terminal dipeptide of tuftsin (Pro-Arg) was found to be much stronger than that of the C-terminal of bradykinin dipeptide Phe-Arg. It was also found that the tripeptide fragment of bradykinin (Pro-Phe-Arg) and its D-Pro analog (D-Pro-Phe-Arg) are deprived of analgesic activity. The attempt to synthesize kyotorphin analogs containing fluorescence label (DMAPhe-Arg and D-DMAPhe-Arg; DMAPhe: 4'-dimethylamino-phenylalanine) resulted in inactive compounds.
A gradient-based approach of history-matching of both production and 4 D seismic data (2000)

The reservoir characterisation methods are still improving the integration of all available data for more accurate predictions, but the litmus test remains the history-matching confrontation, after a period of production, between observed data and simulated data as predicted by the numerical model of the reservoir.
Data Mining of Prognostic Microenvironment-Related Genes in Clear Cell Renal Cell Carcinoma: A Study with TCGA Database (2019)

Clear cell renal cell carcinoma (ccRCC) is one of the most prevalent kidney malignancies. The tumor microenvironment (TME) is highly related to the oncogenesis, progress, and prognosis of ccRCC. The aim of this study was to infer the level of infiltrating stromal and immune cells and assess the prognostic value of them. The gene expression profile was obtained from TCGA and used for calculating the stromal and immune scores. Based on a cut-off value, patients were divided into low- and high-stromal/immune score groups. Survival analysis was performed to evaluate the prognostic value of stromal and immune scores. Moreover, differentially expressed genes (DEGs) that are highly related to TME were determined and applied for functional enrichment analysis and protein-protein interaction (PPI) network. The Kaplan-Meier plot demonstrated that patients with high-immune scores and stromal scores had poorer clinical outcome. In addition, a total of 89 DEGs were identified and mainly involved in 5 pathways. The top 5 degree genes were extracted from the PPI network; among them, IL10 and XCR1 were highly associated with prognosis of ccRCC. The results of the present study demonstrated that ESTIMATE algorithm-based stromal and immune scores may be a credible indicator of cancer prognosis and IL10 along with XCR1 may be a potential key regulator for the TME of ccRCC.
Exxon's new deepwater production riser (1978)

Exxon's deepwater production terminal, applicable at depths over 5000 ft in rough seas, consists of a Single Anchoring Leg Mooring production riser and a floating storage tanker with production facilities on board. The separated gas and water are reinjected into the formation, and shuttle tankers offload the crude oil by tandem mooring to the storage tanker. This paper describes the riser system in detail: installation, design analysis, fatigue. 11 figures. (DLC)
Some aromatic compounds from the marine sponge Plakortis halichondrioides (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSome aromatic compounds from the marine sponge Plakortis halichondrioidesB. N. Ravi, Robert W. Armstrong, and D. John FaulknerCite this: J. Org. Chem. 1979, 44, 18, 3109–3113Publication Date (Print):August 1, 1979Publication History Published online1 May 2002Published inissue 1 August 1979https://pubs.acs.org/doi/10.1021/jo01332a005https://doi.org/10.1021/jo01332a005research-articleACS PublicationsRequest reuse permissionsArticle Views191Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Organic lasers based on lithographically definedphotonic-bandgap resonators (1998)

The authors report the fabrication and characteristics of organic solid-state waveguide lasers with feedback from a photolithographically defined rhomboid photonic bandgap lattice. The lattice is formed by etching holes of depth 10–40 nm in SiO2 and filling them with the organic gain medium. The gain medium is part of a planar waveguide formed by air/organic layer/SiO2.
Indole synthesis – something old, something new (2012)

Indoles, both naturally occurring and synthetic, exhibit wide-ranging biological activity. Unusual and complex molecular architectures occur among their natural derivatives. As a result, this important ring system continues to attract attention from the international chemical community, and new methodologies for the construction of this ever relevant heteroaromatic ring continue to be developed. Unfortunately, many methods frequently start from ortho-substituted anilines, thereby greatly restricting the availability of starting materials. A more general approach would start from a mono-functionalized arene such as an aniline or halobenzene, followed by cyclization with C–C or C–N bond formation to an unactivated C–H bond. Such methods are the subject of this perspective.
Low-loss simple waveguide intersection in silicon photonics (2010)

Proposed is a simple silicon wire intersection with low diffraction loss and crosstalk. Finite-difference time-domain analysis shows the lowest loss to be as small as 0.14 dB. A nearly optimum structure was fabricated on SOI substrate, the measured loss being 0.24 dB, which is only 0.01 dB larger than the theoretical loss.