gebhart/patrepeval huggingface dataset:
Trust-based Service Recommendation in Social Network (2015)

With the number of Web services increasing constantly on the Internet, how to recommend personalized Web services for users has become more and more important. At present, there emerged some service recommendation systems utilizing influence ranking and collaborative filtering algorithms in service r ecommendation. However, they neither considered trust relationships among users, nor deal with the cold start problem very well. Fortunately, the popularity of social network in nowadays brings a good alternative for service recommendation to avoid those. In this study, we propose a social network-based service-recommendation method, which considers users' history service invocation behaviors, us ers preferences as well as trust relationships among users i mplied in social network and users comments/reviews on services. We have applied this method in a data set extracted from www.epinions.com. A series of experiments on 86,719 users, 604,190 user trust-relationships and 963,591 reviews on 292,713 services/produces show that this recommendation method get better recall rate, precision, f-measure and rank score.
Strategies for the Discovery and Advancement of Novel Cationic Antimicrobial Peptides (2010)

Multi-drug resistant bacteria are appearing at an alarming rate and impose significant burdens on healthcare systems worldwide. Cationic peptides have shown great promise as broad spectrum antimicrobial agents with a demonstrated ability to kill resistant bacteria, however, issues such as protease susceptibility and toxicity issues have delayed their clinical development. This review summarizes recent progress in the advancement of cationic antimicrobial peptides for the treatment of bacterial infections. The major focus of the discussion relates to recent advances in the areas of screening and in silico modeling. A selection of novel strategies that diverge from classical linear α-peptide antimicrobials is also discussed. A diverse array of candidate structures will be key to the ultimate development of a stable platform for clinical development. The ability to accurately predict peptide activity in silico and in a high-throughput manner should benefit all classes of cationic antimicrobial peptides and provide a larger set of candidate structures for clinical evaluation.
Coprocessing of hydrocarbonacous waste and residual oil: a novel approach to recycling (1993)

The paper reports on the recovery and recycle of hydrocarbonacous waste materials (used tire rubber, post-consumer plastic and rubber goods) and their simulataneous processing with petroleum residuum to yield high quality distillable oil products
Iron regulates nitric oxide synthase activity by controlling nuclear transcription. (1994)

Recently, it was reported that nitric oxide (NO) directly controls intracellular iron metabolism by activating iron regulatory protein (IRP), a cytoplasmic protein that regulates ferritin translation. To determine whether intracellular iron levels themselves affect NO synthase (NOS), we studied the effect of iron on cytokine-inducible NOS activity and mRNA expression in the murine macrophage cell line J774A.1. We show here that NOS activity is decreased by about 50% in homogenates obtained from cells treated with interferon gamma plus lipopolysaccharide (IFN-gamma/LPS) in the presence of 50 microM ferric iron [Fe(3+)] as compared with extracts from cells treated with IFN-gamma/LPS alone. Conversely, addition of the iron chelator desferrioxamine (100 microM) at the time of stimulation with IFN-gamma/LPS increases NOS activity up to 2.5-fold in J774 cells. These effects of changing the cellular iron state cannot be attributed to a general alteration of the IFN-gamma/LPS signal, since IFN-gamma/LPS-mediated major histocompatibility complex class II antigen expression is unaffected. Furthermore, neither was the intracellular availability of the NOS cofactor tetrahydrobiopterin altered by treatment with Fe(3+) or desferrioxamine, nor do these compounds interfere with the activity of the hemoprotein NOS in vitro. We demonstrate that the mRNA levels for NOS are profoundly increased by treatment with desferrioxamine and reduced by Fe(3+). The half-life of NOS mRNA appeared not to be significantly altered by administration of ferric ion, and NOS mRNA stability was only slightly prolonged by desferrioxamine treatment. Nuclear run-off experiments demonstrate that nuclear transcription of cytokine-inducible NOS mRNA is strongly increased by desferrioxamine whereas it is decreased by Fe(3+). Thus, this transcriptional response appears to account quantitatively for the changes in enzyme activity. Our results suggest the existence of a regulatory loop between iron metabolism and the NO/NOS pathway.
Identification and Expression Analyses of Putative Sesquiterpene Synthase Genes in <i>Phormidium</i> sp. and Prevalence of <i>geoA</i> -Like Genes in a Drinking Water Reservoir (2007)

The occurrence of taste and odor problems in drinking water supplies is a widespread phenomenon. From a Saxonian water reservoir we isolated a cyanobacterial species which was classified as Phormidium sp. Under laboratory conditions it produced an earthy-musty smell due to the synthesis of geosmin. The only genes shown to be involved in geosmin biosynthesis are cyc2 and geoA of Streptomyces. Based on the alignment of Cyc2 with a putative sesquiterpene synthase of Nostoc punctiforme, a degenerate primer pair was designed. By PCR, we could amplify two similar genes in Phormidium sp., which we named geoA1 and geoA2. Their expression was studied by reverse transcription-PCR. This revealed that both genes are expressed at 20 degrees C and a light-dark cycle of 12 h. Expression was not detectable at the end of a 24-h dark period. To analyze the prevalence of geoA1 and geoA2 in samples from the phytobenthos, we generated PCR fragments with the same degenerate primer pair. Fifty-five different sequences that might represent geoA variants were obtained. The GC content ranged from 42% to 67%, suggesting that taxonomically very different bacteria might contain such genes.
<title>Optical sensors for temperature and strain measurement</title> (1996)

The measurement of quasi-static strain field using optical fibers presents a considerable challenge due to the inherent sensitivity of optical fibers to temperature. This paper summarizes recent work we have carried out on two approaches to this problem. Dual mode polarimetric measurements were investigated as a means of implementing distributed temperature measurements and radio frequency subcarrier sensors have been used to perform the same measurement on an integrated basis. These techniques are contrasted and assessed against other technologies such as Bragg gratings and dispersive Fourier transform spectroscopy on the basis of measurement capability, ease of implementation and technological maturity.
Effects of Astragaloside IV on the SDF-1/CXCR4 Expression in Atherosclerosis of apoE<sup>−/−</sup>Mice Induced by Hyperlipaemia (2015)

Astragaloside IV (AsIV) is the major effective component extracted from the Chinese herb Astragalus membranaceus, which has been widely used to treat cardiovascular disease. Recent studies have shown that AsIV can potentially protect the arteries from atherosclerosis; however the mechanisms underneath are unknown. The aim of this study was to investigate the effects of AsIV on blood lipids, CD40-CD40L signal system, and SDF-1/CXCR4 biological axis in high-fat diet apoE(-/-) mice and reveal the molecular mechanisms of AsIV against atherosclerosis. Here, we showed that AsIV alleviated the extent of atherosclerosis in aorta of apoE(-/-) mice. And AsIV can significantly downregulate PAC-1, CD40L, and CXCR4 expression on platelet surface in blood of high-fat diet apoE(-/-) mice. AsIV also can significantly downregulate mRNA and protein level of SDF-1 and CXCR4 in thoracic aorta. Consistent with aorta CXCR4 expression, CXCR4 in bone marrow-derived endothelial progenitor cell (EPC) was also reduced. Meanwhile biochemical analysis showed that AsIV could downregulate TG, TC, and LDL-C levels and upregulate HDL-C level in blood of high-fat diet apoE(-/-) mice. We concluded that the protective effects of AsIV in atherosclerosis injury may be related to regulating blood lipids, CD40-CD40L system, and SDF-1/CXCR4 biological axis. SDF-1/CXCR4 biological axis is probably one of the main targets of intervening atherosclerosis.
A 10-bit 200-MS/s CMOS parallel pipeline A/D converter (2001)

This paper describes a 10-bit 200-MS/s CMOS parallel pipeline analog-to-digital (A/D) converter that can sample input frequencies above 200 MHz. The converter utilizes a front-end sample-and-hold (S/H) circuit and four parallel interleaved pipeline component A/D converters followed by a digital offset compensation. By optimizing for power in the architectural level, incorporating extensively parallelism and double-sampling both in the S/H circuit and the component ADCs, a power dissipation of only 280 mW from a 3.0-V supply is achieved. Implemented in a 0.5-/spl mu/m CMOS process, the circuit occupies an area of 7.4 mm/sup 2/. The converter achieves a differential nonlinearity and integral nonlinearity of /spl plusmn/0.8 LSB and /spl plusmn/0.9 LSB, respectively, while the peak spurious-free-dynamic-range is 55 dB and the total harmonic distortion better than 46 dB at a sampling rate of 200 MS/s.
Optical sparse aperture imaging (2007)

The resolution of a conventional diffraction-limited imaging system is proportional to its pupil diameter. A primary goal of sparse aperture imaging is to enhance resolution while minimizing the total light collection area; the latter being desirable, in part, because of the cost of large, monolithic apertures. Performance metrics are defined and used to evaluate several sparse aperture arrays constructed from multiple, identical, circular subapertures. Subaperture piston and/or tilt effects on image quality are also considered. We selected arrays with compact nonredundant autocorrelations first described by Golay. We vary both the number of subapertures and their relative spacings to arrive at an optimized array. We report the results of an experiment in which we synthesized an image from multiple subaperture pupil fields by masking a large lens with a Golay array. For this experiment we imaged a slant edge feature of an ISO12233 resolution target in order to measure the modulation transfer function. We note the contrast reduction inherent in images formed through sparse aperture arrays and demonstrate the use of a Wiener-Helstrom filter to restore contrast in our experimental images. Finally, we describe a method to synthesize images from multiple subaperture focal plane intensity images using a phase retrieval algorithm to obtain estimates of subaperture pupil fields. Experimental results from synthesizing an image of a point object from multiple subaperture images are presented, and weaknesses of the phase retrieval method for this application are discussed.
A miniature bidirectional telemetry system for<i>in vivo</i>gastric slow wave recordings (2012)

Stomach contractions are initiated and coordinated by an underlying electrical activity (slow waves), and electrical dysrhythmias accompany motility diseases. Electrical recordings taken directly from the stomach provide the most valuable data, but face technical constraints. Serosal or mucosal electrodes have cables that traverse the abdominal wall, or a natural orifice, causing discomfort and possible infection, and restricting mobility. These problems motivated the development of a wireless system. The bidirectional telemetric system constitutes a front-end transponder, a back-end receiver and a graphical userinter face. The front-end module conditions the analogue signals, then digitizes and loads the data into a radio for transmission. Data receipt at the backend is acknowledged via a transceiver function. The system was validated in a bench-top study, then validated in vivo using serosal electrodes connected simultaneously to a commercial wired system. The front-end module was 35 × 35 × 27 mm3 and weighed 20 g. Bench-top tests demonstrated reliable communication within a distance range of 30 m, power consumption of 13.5 mW, and 124 h operation when utilizing a 560 mAh, 3 V battery. In vivo,slow wave frequencies were recorded identically with the wireless and wired reference systems (2.4 cycles min−1), automated activation time detection was modestly better for the wireless system (5% versus 14% FP rate), and signal amplitudes were modestly higher via the wireless system (462 versus 3 86μV; p<0.001). This telemetric system for slow wave acquisition is reliable,power efficient, readily portable and potentially implantable. The device will enable chronic monitoring and evaluation of slow wave patterns in animals and patients.0967-3334/
Is placebo as effective as estrogen regimens on vasomotor symptoms in women with surgical menopause? (2010)

Estrogen regimens and placebo seem to be effective in alleviating vasomotor symptoms. Additional larger prospective randomized studies need to be conducted in an aim to look at not only short-term but also long-term effects on climacteric symptoms, in comparison to both placebo arms and different dose and mode of HT use.
Dendritic Cells Cross-Dressed with Peptide MHC Class I Complexes Prime CD8+ T Cells (2006)

The activation of naive CD8+ T cells has been attributed to two mechanisms: cross-priming and direct priming. Cross-priming and direct priming differ in the source of Ag and in the cell that presents the Ag to the responding CD8+ T cells. In cross-priming, exogenous Ag is acquired by professional APCs, such as dendritic cells (DC), which process the Ag into peptides that are subsequently presented. In direct priming, the APCs, which may or may not be DC, synthesize and process the Ag and present it themselves to CD8+ T cells. In this study, we demonstrate that naive CD8+ T cells are activated by a third mechanism, called cross-dressing. In cross-dressing, DC directly acquire MHC class I-peptide complexes from dead, but not live, donor cells by a cell contact-mediated mechanism, and present the intact complexes to naive CD8+ T cells. Such DC are cross-dressed because they are wearing peptide-MHC complexes generated by other cells. CD8+ T cells activated by cross-dressing are restricted to the MHC class I genotype of the donor cells and are specific for peptides generated by the donor cells. In vivo studies demonstrate that optimal priming of CD8+ T cells requires both cross-priming and cross-dressing. Thus, cross-dressing may be an important mechanism by which DC prime naive CD8+ T cells and may explain how CD8+ T cells are primed to Ags that are inefficiently cross-presented.
Voltammetric Determination of Uric Acid at a Fullerene‐C<sub>60</sub>‐Modified Glassy Carbon Electrode (2005)

Abstract Glassy carbon electrode modified by microcrystals of fullerene‐C 60 mediates the voltammetric determination of uric acid (UA) in the presence of ascorbic acid (AA). Interference of AA was overcome owing to the ability of pretreated fullerene‐C 60 ‐modified glassy carbon electrode. Based on its strong catalytic function towards the oxidation of UA and AA, the overlapping voltammetric response of uric acid and ascorbic acid is resolved into two well‐defined voltammetric peaks with lowered oxidation potential and enhanced oxidation currents under conditions of both linear sweep voltammetry (LSV) and Osteryoung square‐wave voltammetry (OSWV). At pH 7.2, a linear calibration graph is obtained for UA in linear sweep voltammetry over the range from 0.5 μM to 700 μM with a correlation coefficient of 0.9904 and a sensitivity of 0.0215 μA μM −1 . The detection limit (3 σ ) is 0.2 μM for standard solution. AA in less than four fold excess does not interfere. The sensitivity and detection limit in OSWV were found as 0.0255 μA μM −1 and 0.12 μM, for standard solution respectively. The presence of physiologically common interferents (i.e. adenine, hypoxanthine and xanthine) negligibly affects the response of UA. The fullerene‐C 60 ‐modified electrode exhibited a stable, selective and sensitive response to uric acid in the presence of interferents.
CCF: Collaborative Computing Frameworks (1998)

CCF (Collaborative Computing Frameworks) is a suite of software systems, communications protocols, and tools that enable collaborative, computer-based cooperative work. CCF constructs a virtual work environment on multiple computer systems connected over the Internet, to form a Collaboratory. In this setting, participants interact with each other, simultaneously access and operate computer applications, refer to global data repositories or archives, collectively create and manipulate documents or other artifacts, perform computational transformations, and conduct a number of other activities via telepresence. Research issues addressed in this project include problem solving environments and methodologies for laboratory and instrument-based scientific disciplines, and computer science issues in heterogeneous distributed systems. New approaches are being investigated and developed for fast multiway communication, robust geographically distributed data management methodologies, high-performance computational transforms inlined within collaboration sessions, and related auxiliary issues such as active documents, security, archival storage, and experiment management and control. In this paper, we discuss the design philosophy and systems rationale behind CCF, describe the major subsystems of the collaborative computing environment, and discuss the salient features of the system.
Poly(glycidyl methacrylate): a highly versatile polymeric building block for post-polymerization modifications (2012)

The treatment of poly(glycidyl methacrylate) with nucleophilic agents yielded new linear homo/co-polymers. The materials obtained have different physicochemical properties depending upon the nucleophiles utilized and thus, by this way, water soluble polymers are easily accessible. This approach is also very convenient for the synthesis of amphiphilic block copolymers. Additional chemical modifications can further transform the obtained polymers after the post-polymerization treatment. Starting from RAFT pre-synthesized/pre-functionalized polymers, the described procedures allow us to obtain a wide variety of chemically diverse materials characterized by controlled structure and specific functions.
A protocol for the purification of bovine serum albumin free of deoxyribonuclease activity. (1990)

Bovine serum albumin, free of deoxyribonuclease activity, was obtained in our laboratory using ion-exchange chromatography followed by acetylation. Chromatography on four different resins (DEAE-52, P-11, hydroxylapatite and Q Sepharose fast-flow) was examined. Fractions from Q Sepharose chromatography, eluted with a linear gradient 0-1.0 M NaCl and subsequently acetylated, proved to be the most effective method for obtaining deoxyribonuclease-free bovine serum albumin.
Tranilast Inhibits the Proliferation of Uterine Leiomyoma Cells<i>in Vitro</i>through G1 Arrest Associated with the Induction of p21<sup>waf1</sup>and p53 (2002)

Uterine leiomyoma is a mesenchymal tumor composed of smooth muscle cells with fibrous tissues and many mast cells. Tranilast is known to suppress fibrosis or to work as a mast cell stabilizer and is reported to inhibit proliferation of vascular smooth muscle cells. In this study, we examined the effects of tranilast on cultured human leiomyoma cells in vitro to evaluate whether this agent has the potential to inhibit the growth of uterine leiomyomas. Tranilast inhibited the proliferation of cultured leiomyoma cells in a dose-dependent manner without any cytotoxic effect or induction of apoptosis. In association with the inhibitory effect, tranilast induced the cyclin-dependent kinase (CDK) inhibitor p21(waf1) and tumor suppressor gene p53 and decreased CDK2 activity. These results suggest that tranilast arrests the proliferation of uterine leiomyoma cells at the G0/G1 phase, through the suppression of CDK2 activity via an induction of p21(waf1) and p53. Tranilast was concluded to be a potent agent to inhibit proliferative activity of uterine leiomyoma cells.
Melt Pool Temperature Control for Laser Metal Deposition Processes—Part I: Online Temperature Control (2010)

Melt pool temperature is of great importance to deposition quality in laser metal deposition processes. To control the melt pool temperature, an empirical process model describing the relationship between the temperature and process parameters (i.e., laser power, powder flow rate, and traverse speed) is established and verified experimentally. A general tracking controller using the internal model principle is then designed. To examine the controller performance, three sets of experiments tracking both constant and time-varying temperature references are conducted. The results show the melt pool temperature controller performs well in tracking both constant and time-varying temperature references even when process parameters vary significantly. However a multilayer deposition experiment illustrates that maintaining a constant melt pool temperature does not necessarily lead to uniform track morphology, which is an important criteria for deposition quality. The reason is believed to be that different melt pool morphologies may have the same temperature depending on the dynamic balance of heat input and heat loss.
Combinatorial synthesis of oligosaccharide library of 2,6-dideoxysugars (1998)

Two combinatorial libraries composed of linear trisaccharides of 2,6-dideoxy-l-sugars have been constructed: All possible regioisomeric trisaccharides with 2-iodo and with 2-deoxy moieties were synthesized by an iodonium ion-catalyzed “stereoselective-yet-nonregioselective” glycosylation reaction.
Partial Response and Nonresponse to Antidepressant Therapy (2002)

On the basis of a review of the medical literature and clinical experience regarding patients with partial response or nonresponse to antidepressant drug therapy, it appears that simultaneous targeting of both the noradrenergic and serotonergic systems is one of the most effective augmentation strategies. Switching to an agent of a different class is probably optimal for those patients who fail to respond to first-line therapy.
Color and constitution. Part <b>8</b>. Some novel dyestuffs containing indoxyl residues (1988)

Abstract Novel dyes containing C ‐likned indoxyl residues are prepared by two routes: (a) by the reaction of C ‐electrophiles with N ‐acetylindoxyl and (b) by the reaction of active methylene compounds with 2‐chloroindole‐3‐one. The visible absorption spectra are recorded and discussed.
Detection of GAD65 Autoreactive T‐Cells by HLA Class I Tetramers in Type 1 Diabetic Patients (2009)

Type 1 diabetes (T1D) is an autoimmune disease, in which pancreatic beta cells are destroyed in genetically predisposed individuals. While the direct contribution of autoantibodies to the disease pathogenesis is controversial, it is generally recognised that the mechanism of beta cell destruction is mediated by autoreactive T cells that had escaped the thymic selection. We aimed to design a method to detect circulating CD8+ T cells autoreactive against an epitope of the glutamic acid decarboxylase autoantigen, isoform 65 (GAD65) ex vivo in T1D patients by using HLA class I tetramers. Low frequencies of GAD65 peptide-specific CD8+ cytotoxic T lymphocytes were detected in peripheral blood lymphocytes (PBMC) of normal controls after GAD65 peptide-specific stimulation. Conversely, their frequencies were significantly higher than in controls in PBMC of T1D patients after GAD65 peptide stimulation. These preliminary data are encouraging in order to develop a reliable assay to be employed in large-scale screening studies.