gebhart/patrepeval huggingface dataset:
Safety and Efficacy of Robotic Radiosurgery for Visceral and Lymph Node Metastases of Renal Cell Carcinoma: A Retrospective, Single Center Analysis (2021)

Despite rapid advances of systemic therapy options in renal cell carcinoma (RCC), local tumor or metastases treatment remains important in selected patients. Here, we assess the safety and efficacy of robotic radiosurgery (RRS) as an ablative therapy for visceral and lymph node metastases of RCC. Patients with histologically confirmed RCC and radiologically confirmed progression of visceral or lymph node metastases underwent RRS and were retrospectively analyzed. Overall survival and progression free survival were calculated by the Kaplan-Meier method and log-rank test. Sixty patients underwent RRS and were included in the analysis. Patients presented for RRS treatment with a median age at RRS treatment of 64 years (range 42-83), clear cell histology (88.3%) and favorable international metastatic renal cell carcinoma database (IMDC) risk score (58.3%). Treatment parameters differed for the number of fractions (median visceral metastases: 1, range 1-5; median lymph node metastases: 1, range 0-5; <i>p</i> = 0.003) and prescription dose (median visceral metastases 24 Gy, range 8-26; median lymph node metastases 18 Gy, range 7-26, <i>p</i> < 0.001). The median overall survival was 65.7 months (range: 2.9-108.6), the median progression free survival was 17.4 months (range: 2.7-70.0) and local tumor control was achieved in 96.7% of patients. Adverse events were limited to 8.3% of patients, with one grade 4 toxicity within 6 weeks after RRS therapy. RRS is a safe and effective treatment option in selected patients with metastatic RCC in a multimodal approach. Further research is warranted to confirm our findings prospectively.
WONG ON DAVIDSON (1995)

L'argument de Davidson de l'interprete omniscient repose sur le presuppose qu'un interprete omniscient est possible, et que certaines conditions existent pour une interpretation reussie. L'A. retrace cet argument et discute la critique de Wong pour qui l'idee meme d'un interprete omniscient est incoherente
Hidden Cliques as Cryptographic Keys (1996)

We demonstrate in this paper a very simple method for "hiding" large cliques in random graphs. While the largest clique in a random graph is very likely to be of size about 2log2<i>n</i>, it is widely conjectured that no polynomial-time algorithm exists which finds a clique of size (1 + epsilon)log2<i>n</i> with significant probability for any constant epsilon > 0. We show that if this conjecture is true, then when a clique of size at most (2 - delta)log2<i>n</i> for constant delta > 0 is randomly inserted ("hidden") in a random graph, finding a clique of size (1 + epsilon)log2<i>n</i> remains hard. In particular, we show that if there exists a polynomial-time algorithm which finds cliques of size (1 + epsilon)log2<i>n</i> in such graphs with probability 1/poly, then the same algorithm will find cliques in completely random graphs with probability 1/poly. Given the conjectured hardness of finding large cliques in random graphs, we therefore show that hidden cliques may be used as cryptographic keys
Tertiary and quaternary local anesthetics protect CNS white matter from anoxic injury at concentrations that do not block excitability (1992)

1. Anoxic injury in CNS white matter was studied using the in vitro rat optic nerve preparation. Optic nerves were subjected to 60 min of anoxia, and functional recovery was assessed using the area under the compound action potential (CAP). In normal cerebrospinal fluid, CAP area recovered to 33.5 +/- 9.3% (SD) of control. 2. Lidocaine and procaine (0.1 or 1.0 mM), applied beginning 1 h before anoxia, significantly improved postanoxic recovery of CAP area. However, both agents also depressed the preanoxic CAP. Procaine generally allowed greater recovery with less depression compared with lidocaine. 3. The quaternary derivatives QX-314 (0.1-1.0 mM) and QX-222 (0.3-3.0 mM) resulted in more complete recovery of the CAP area from anoxia, with less depression of preanoxic excitability, compared with the tertiary compounds. At 0.3 mM, QX-314 reduced the preanoxic CAP very little (to 94.4 +/- 14% of control CAP area), yet allowed the postanoxic CAP area to recover to 99.6 +/- 19%. 4. We conclude that quaternary local anesthetics are more effective at protecting CNS white matter tracts from anoxia than tertiary compounds and that these agents can result in markedly improved recovery even at concentrations that do not block conduction. Moreover, given the relative specificity of QX-314 for noninactivating Na+ channels, we hypothesize that this channel subtype plays an important role in mediating anoxic injury in central myelinated axons.
Automatic power control with electronic amplified spontaneous emission compensation (2007)

Semiconductor-based optical amplifiers (SOAs) offer solutions to a variety of amplification needs covering wavelengths ranging from of 0.6 to 1.6 µm. Gain adjustment, through the bias current, enables automatic power control to be implemented. However, this requires knowledge of the signal strength. The amplified spontaneous emission power, particularly in high gain SOAs, can be significant with respect to the signal strength, and therefore additional components may be required to derive an accurate measure of the signal strength. This increases both the complexity and cost of implementing automatic power control (APC). We report on a method for estimating the signal strength based on measurement of the total output power and the SOA drive current. The method is extendable to other methods of optical amplification, e.g., erbium-doped fiber amplifiers.
Rare expression of epithelial cell adhesion molecule on residual micrometastatic breast cancer cells after adjuvant chemotherapy. (2003)

Our results indicate that disseminated breast cancer cells in BM can survive first-line adjuvant chemotherapy. Ep-CAM expression is, however, restricted to a subset of these cells, which may limit the broad applicability of Ep-CAM as target for second-line adjuvant therapy in breast cancer.
Nonsteroidal antiinflammatory drugs and human cancer. Report of an interdisciplinary research workshop (1994)

Combined evidence from different research disciplines strongly supports the notion that aspirin and other NSAIDs act to prevent the development or progression of certain human gastrointestinal cancers, especially colorectal cancer. Consequently, the workshop recommended that randomized prevention trials be undertaken. For various logistic reasons, such trials probably should focus on NSAID effects on the occurrence and progression of colorectal polyps rather than on carcinoma itself. Continued research also is needed to clarify further the pharmacologic, clinical, and epidemiologic nature of NSAIDs' influences on human carcinogenesis.
BundleFusion: Real-time Globally Consistent 3D Reconstruction using On-the-fly Surface Re-integration (2016)

Real-time, high-quality, 3D scanning of large-scale scenes is key to mixed reality and robotic applications. However, scalability brings challenges of drift in pose estimation, introducing significant errors in the accumulated model. Approaches often require hours of offline processing to globally correct model errors. Recent online methods demonstrate compelling results, but suffer from: (1) needing minutes to perform online correction preventing true real-time use; (2) brittle frame-to-frame (or frame-to-model) pose estimation resulting in many tracking failures; or (3) supporting only unstructured point-based representations, which limit scan quality and applicability. We systematically address these issues with a novel, real-time, end-to-end reconstruction framework. At its core is a robust pose estimation strategy, optimizing per frame for a global set of camera poses by considering the complete history of RGB-D input with an efficient hierarchical approach. We remove the heavy reliance on temporal tracking, and continually localize to the globally optimized frames instead. We contribute a parallelizable optimization framework, which employs correspondences based on sparse features and dense geometric and photometric matching. Our approach estimates globally optimized (i.e., bundle adjusted) poses in real-time, supports robust tracking with recovery from gross tracking failures (i.e., relocalization), and re-estimates the 3D model in real-time to ensure global consistency; all within a single framework. Our approach outperforms state-of-the-art online systems with quality on par to offline methods, but with unprecedented speed and scan completeness. Our framework leads to a comprehensive online scanning solution for large indoor environments, enabling ease of use and high-quality results.
A dança final (2012)

Programa tradicional, articulado em uma parte; quadricromia; 21 cm x 15 cm (peca fechada), 21 cm x 30 cm (peca aberta). 
Acompanha ingresso para apresentacao do dia 18/04/2010
Hypothermia for neuroprotection in adults after cardiopulmonary resuscitation. (2010)

Compared with standard care, therapeutic hypothermia with conventional cooling methods improves the rate of survival to hospital discharge and neurologic outcome in patients successfully resuscitated after cardiac arrest.
Imbalance in the Pro–Hepatocyte Growth Factor Activation System in Bleomycin-Induced Lung Fibrosis in Mice (2009)

Hepatocyte growth factor (HGF) is a growth factor for alveolar epithelial cells. Activation of pro-HGF to HGF is regulated by the HGF activator (HGFA), a serine protease, and a specific inhibitor (HGFA inhibitor-1, HAI-1). An imbalance in the HGFA/HAI-1 system might contribute to lung fibrosis. Pro-HGF activation capacity from bronchoalveolar lavage (BAL) fluid was evaluated 3, 7, and 14 days after the intratracheal bleomycin injection (Bleo) in mice with or without thrombin. BAL fluid from naïve mice was used as control. HGFA and HAI-1 mRNA were evaluated by QPCR in the whole lung or by Western blot in BAL fluid. BAL fluid from control mice and Bleo mice activated pro-HGF in vitro at a similar degree. Thrombin accelerated proHGF activation by Bleo BAL on Day 3 and Day 7, but not on Day 14, or in control BAL. Incubation of pro-HGF with BAL from Bleo Day 3 and Day 7 mice increased phosphorylation of HGFR on A549 cells. Thrombin-induced pro-HGF activation was inhibited by an anti-HGFA antibody and accelerated by an anti-HAI-1 antibody. Active HGFA was not detected in control BAL and was strongly induced in Bleo BAL. HGFA concentrations were higher on Day 3 and Day 7 than on Day 14. HAI-1 was detected at low levels in control BAL and increased strongly by Day 3 with stable concentrations until Day 14. By demonstrating an imbalance between HGFA and HAI-1 expression in BAL fluid, our results highlight a defective thrombin-dependent proHGF activation system at the fibrotic phase of bleomycin-induced pulmonary fibrosis.
A Robust High-&lt;tex&gt;$Q$&lt;/tex&gt;Micromachined RF Inductor for RFIC Applications (2005)

In this paper, a robust micromachined spiral inductor with a cross-shaped sandwich membrane support is proposed and fabricated with fully CMOS compatible post-processes for radio frequency integrated circuit (RFIC) applications. Using the incorporation of a sandwich dielectric membrane (0.7 /spl mu/m SiO/sub 2//0.7 /spl mu/m Si/sub 3/N/sub 4//0.7 /spl mu/m TEOS) to enhance the structure rigidity, the inductor can have better signal stability. In comparison, the new design of a /spl sim/5-nH micromachined inductor can have 45% less inductance variation than the one without the dielectric support while both devices are operated with 10 m/s/sup 2/ acceleration. Meanwhile, using a cross shape instead of blanket membrane can also effectively eliminate the inductance variation induced by the working temperature change (20/spl deg/C to 75/spl deg/C). The measurement results show the robust inductor can have similar electrical performance to the as-fabricated freely suspended inductor, which has five times Q (quality factor) improvement than the inductor without the substrate removal. It is our belief that the new micromachined inductors can have not only high-Q performance but also better signal stability suitable for wide-range RFIC applications.
Quadrature Overlapped Raised-Cosine Modulation (1981)

A variation of an old but neglected pulse shaping technique, raised-cosine, is investigated. By overlapping raised-cosine pulses in each of two data streams and then by quadrature combining them, a simple QPSK/MSK type modulation results. This quadrature overlapped raised-cosine (QORC) modulation exhibits a hybrid structure of QPSK and MSK modulations. The power spectral density of QORC is shown to take on the form of the product of the power spectral densities of MSK and QPSK. The obvious consequences are that the power spectral density main lobe retains the width of the spectral density main lobe of QPSK, but the sidelobes drop off much faster <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">(1/f^{6})</tex> . A simple QORC modulator can be implemented similar to an MSK modulator. Several correlation type receivers are investigated and their performances calculated. Computer simulation results are used to compare end-to-end system performance of QORC and staggered QORC (SQORC) with MSK, QPSK, and staggered QPSK (SQPSK) for both linear and nonlinear satellite channels. The performance of QORC and SQORC compares very favorably with QPSK, SQPSK, and MSK. QORC performs particularly well in the presence of a nonlinear channel. The effect of phase equalization of the channel filter was investigated with outstanding performance improvement. The simulation results show that sidelobe regeneration caused by the channel nonlinearity is much less for SQORC than it is for the other modulation formats considered.
Fourier-Mellin Spatial Filters For Invariant Pattern Recognition (1989)

We use the kernel function of the circular Fourier and radial Mellin transforms to make spatial filters and extract shift, rotation, and scale invariant features from the 2-D correlation outputs. Using a small bank of filters, this approach allows pattern recognition for multiple input objects that is invariant to their independent distortions. These Fourier-Mellin spatial filters can be phase-only and binary phase-only filters and implemented in real time using commercially available spatial light modulators. These filters are suitable as preprocessors in artificial neuron networks for adaptive and self-organizing pattern recognition. Computer simulation results are shown.
Switching between molecular switch types by module rearrangement: Ca<sup>2+</sup>-enabled, H<sup>+</sup>-driven ‘Off–On–Off’, H<sup>+</sup>-driven YES and PASS 0 as well as H<sup>+</sup>, Ca<sup>2+</sup>-driven AND logic operations (2004)

Several logic gates and switches can be accessed from two different combinations of a single set of fluorophore, receptor and spacer components.
Hydrogen sulfide and asthma (2011)

Asthma is a chronic inflammatory disease, with hyper-responsive bronchoconstriction and airway remodelling, leading to extensive airway narrowing. The regulation of airway responsiveness and inflammation by endogenous hydrogen sulfide (H(2)S) during the pathogenic development of asthma has been suggested. Hydrogen sulfide can be produced in the lung and airway tissues via the actions of two H(2)S-generating enzymes, cystathionine β-synthase (CBS) and/or cystathionine γ-lyase (CSE). The abnormal metabolism and function of H(2)S have been reported in experimental animals with asthma, especially ovalbumin-induced rat or mouse models. In patients with asthma, serum H(2)S levels are significantly reduced. Supplementation with exogenous H(2)S has been shown to mitigate the severity of asthma in experimental animals. It is hypothesized that decreased H(2)S production in the lung and airway tissues may be used as an early detection biomarker, and H(2)S-based therapy would represent a new treatment strategy for asthma. Major challenges for establishing the diagnostic and treatment values of H(2)S include the differential expression of CSE and CBS along the airway and their changes during asthma, the effects of H(2)S on bronchoconstriction and airway remodelling, as well as the underlying mechanisms, and the detection of the changes in H(2)S levels in airway tissues and in exhaled air.
Granada Crystallisation Box: a new device for protein crystallisation by counter-diffusion techniques (2002)

Granada Crystallisation Box (GCB) is a new crystallisation device designed to perform counter-diffusion experiments. Here we describe the device and its use for protein crystallisation purposes. GCB allows one to explore and exploit the coupling between crystallisation and diffusion. The role of viscous fluids, gels and/or microgravity can be enhanced by using capillary volumes, creating a perfect diffusive mass transport scenario. The use of capillaries also reduces the consumption of macromolecules and avoids the handling of crystals for X-ray diffraction data collection.
Delay tolerant bulk data transfers on the internet (2009)

Many emerging scientific and industrial applications require transferring multiple Tbytes of data on a daily basis. Examples include pushing scientific data from particle accelerators/colliders to laboratories around the world, synchronizing data-centers across continents, and replicating collections of high definition videos from events taking place at different time-zones. A key property of all above applications is their ability to tolerate delivery delays ranging from a few hours to a few days. Such Delay Tolerant Bulk (DTB) data are currently being serviced mostly by the postal system using hard drives and DVDs, or by expensive dedicated networks. In this work we propose transmitting such data through commercial ISPs by taking advantage of already-paid-for off-peak bandwidth resulting from diurnal traffic patterns and percentile pricing. We show that between sender-receiver pairs with small time-zone difference, simple source scheduling policies are able to take advantage of most of the existing off-peak capacity. When the time-zone difference increases, taking advantage of the full capacity requires performing store-and-forward through intermediate storage nodes. We present an extensive evaluation of the two options based on traffic data from 200+ links of a large transit provider with PoPs at three continents. Our results indicate that there exists huge potential for performing multi Tbyte transfers on a daily basis at little or no additional cost.
5 Het TOPOI-model (2009)

De gelaagdheid en circulariteit maken dat communicatie een complex proces is. Vandaar dat misverstanden eigen zijn aan de communicatie. In dat opzicht verschilt de communicatie met iemand met een andere etnische achtergrond – behalve mogelijk de taal
Evaluation of Approaches to Monitor Staphylococcus aureus Virulence Factor Expression during Human Disease (2015)

Staphylococcus aureus is a versatile pathogen of medical significance, using multiple virulence factors to cause disease. A prophylactic S. aureus 4-antigen (SA4Ag) vaccine comprising capsular polysaccharide (types 5 and 8) conjugates, clumping factor A (ClfA) and manganese transporter C (MntC) is under development. This study was designed to characterize S. aureus isolates recovered from infected patients and also to investigate approaches for examining expression of S. aureus vaccine candidates and the host response during human infection. Confirmation of antigen expression in different disease states is important to support the inclusion of these antigens in a prophylactic vaccine. Hospitalized patients with diagnosed S. aureus wound (27) or bloodstream (24) infections were enrolled. Invasive and nasal carriage S. aureus isolates were recovered and characterized for genotypic diversity. S. aureus antigen expression was evaluated directly by real-time, quantitative, reverse-transcriptase PCR (qRT-PCR) analysis and indirectly by serology using a competitive Luminex immunoassay. Study isolates were genotypically diverse and all had the genes encoding the antigens present in the SA4Ag vaccine. S. aureus nasal carriage was detected in 55% of patients, and in those subjects 64% of the carriage isolates matched the invasive strain. In swab samples with detectable S. aureus triosephosphate isomerase housekeeping gene expression, RNA transcripts encoding the S. aureus virulence factors ClfA, MntC, and capsule polysaccharide were detected by qRT-PCR. Antigen expression was indirectly confirmed by increases in antibody titer during the course of infection from acute to convalescent phase. Demonstration of bacterial transcript expression together with immunological response to the SA4Ag antigens in a clinically relevant patient population provides support for inclusion of these antigens in a prophylactic vaccine.
Software project planning for robustness and completion time in the presence of uncertainty using multi objective search based software engineering (2009)

All large-scale projects contain a degree of risk and uncertainty. Software projects are particularly vulnerable to overruns, due to the this uncertainty and the inherent difficulty of software project cost estimation. In this paper we introduce a search based approach to software project robustness. The approach is to formulate this problem as a multi objective Search Based Software Engineering problem, in which robustness and completion time are treated as two competing objectives. The paper presents the results of the application of this new approach to four large real-world software projects, using two different models of uncertainty.
Comparative Physiological Evidence that β-Alanine Betaine and Choline-<i>O</i>-Sulfate Act as Compatible Osmolytes in Halophytic <i>Limonium</i> Species (1991)

The quaternary ammonium compounds accumulated in saline conditions by five salt-tolerant species of Limonium (Plumbaginaceae) were analyzed by fast atom bombardment mass spectrometry. Three species accumulated beta-alanine betaine and choline-O-sulfate; the others accumulated glycine betaine and choline-O-sulfate. Three lines of evidence indicated that beta-alanine betaine and choline-O-sulfate replace glycine betaine as osmo-regulatory solutes. First, tests with bacteria showed that beta-alanine betaine and choline-O-sulfate have osmoprotective properties comparable to glycine betaine. Second, when beta-alanine betaine and glycine betaine accumulators were salinized, the levels of their respective betaines, plus that of choline-O-sulfate, were closely correlated with leaf solute potential. Third, substitution of sulfate for chloride salinity caused an increase in the level of choline-O-sulfate and a matching decrease in glycine betaine level. Experiments with (14)C-labeled precursors established that beta-alanine betaine accumulators did not synthesize glycine betaine and vice versa. These experiments also showed that beta-alanine betaine synthesis occurs in roots as well as leaves of beta-alanine betaine accumulators and that choline-O-sulfate and glycine betaine share choline as a precursor. Unlike glycine betaine, beta-alanine betaine synthesis cannot interfere with conjugation of sulfate to choline by competing for choline and does not require oxygen. These features of beta-alanine betaine may be advantageous in sulfate-rich salt marsh environments.