1532 LINEAR CORRELATION AND REGRESSION BETWEEN SEVERITY OF URGE SENSATION AND VOIDED VOLUME IN SUBJECTS WITH OVERACTIVE BLADDER: A DIFFERENT APPROACH TO UNDERSTANDING URGENCY (2010)

You have accessJournal of UrologyUrodynamics/Incontinence/Female Urology: Non-Neurogenic Voiding Dysfunction I1 Apr 20101532 LINEAR CORRELATION AND REGRESSION BETWEEN SEVERITY OF URGE SENSATION AND VOIDED VOLUME IN SUBJECTS WITH OVERACTIVE BLADDER: A DIFFERENT APPROACH TO UNDERSTANDING URGENCY Zhonghong Guan, Miriam Harel, Jerry G. Blaivas, Joseph Wang, and Jeffrey P. Weiss Zhonghong GuanZhonghong Guan Brooklyn, NY , Miriam HarelMiriam Harel Brooklyn, NY , Jerry G. BlaivasJerry G. Blaivas Brooklyn, NY , Joseph WangJoseph Wang New York, NY , and Jeffrey P. WeissJeffrey P. Weiss Brooklyn, NY View All Author Informationhttps://doi.org/10.1016/j.juro.2010.02.1283AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Urgency is the key symptom of overactive bladder (OAB). We evaluated the relationship between severity of urge sensation (SUS) and voided volume (VV) per micturition among subjects with OAB. METHODS Baseline 7-day bladder diary data from 2 pooled tolterodine nighttime dosing studies were used. 1 1697 subjects with frequency, urgency, nocturia, and a mean VV <200 mL were enrolled. SUS per micturition was recorded using a 5-point scale: 1 = no urgency, 2 = mild urgency, 3 = moderate urgency, 4 = severe urgency, 5 = urge incontinence. Only days on which subjects recorded all urine volumes were included. Average VV per SUS and per subject at baseline were calculated. Pearson correlations between VV and SUS (1-4 only, VV with SUS 5 were excluded due to urine leakage) per micturition were generated for all subjects. Linear regression lines between baseline VV and SUS were generated using intercept and slope (coefficient of SUS from least squares estimation) of a linear regression model. Only subjects without missing data were used. RESULTS Baseline SUS directly and linearly correlated with baseline VV (r=0.47). The intercept and slope of the linear VV-SUS regression line were 53.28 mL and 30.57, respectively (R2=0.22, Fig.). Linear VV-SUS regression lines were different between subjects without UI vs those with UI and between daytime vs nighttime micturitions. The slope was higher in subjects without UI (34.44 vs 26.11), and the intercept was higher for nighttime micturitions (62.56 mL vs 57.49 mL). The linear VV-SUS regression lines for men vs women and subjects <65 y vs ¡Ý65 y were similar. CONCLUSIONS In this OAB population, SUS correlated linearly with VV, suggesting that the intensity of the urge to void is related, at least in part, to increasing bladder volume. If the linear VV- SUS regression line slope is higher in non-OAB subjects, 2 then decreased urgency threshold indicated by the VV-SUS regression line could be used as a potential biomarker for OAB. The urgency threshold triggered by bladder volume appears to be higher in OAB subjects without UI and for nighttime micturitions. References 1 : Eur Urol2007; 51: 1054. Google Scholar 2 : Neurourol Urodyn2008; 27: 511. Google Scholar © 2010 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 183Issue 4SApril 2010Page: e591 Advertisement Copyright & Permissions© 2010 by American Urological Association Education and Research, Inc.MetricsAuthor Information Zhonghong Guan Brooklyn, NY More articles by this author Miriam Harel Brooklyn, NY More articles by this author Jerry G. Blaivas Brooklyn, NY More articles by this author Joseph Wang New York, NY More articles by this author Jeffrey P. Weiss Brooklyn, NY More articles by this author Expand All Advertisement Advertisement PDF DownloadLoading ...