gebhart/patrepeval huggingface dataset:
High-Speed Photography In Detonics (1985)

The term of "detonics" is generally applied to all the physical phenomena that occur in connection with the detonation of conventional high explosives. The reaction and/or detonation velocities are of the order of 1000 m/s to 9000 m/s, at pressures of several hundreds of kbar. In order to obtain records or pictures of the detonative event with little motion blur and high time resolution, exposure times of less than 10 ns and frame rates higher than 106/s are desirable. About one or two decades ago, new discoveries and improved knowledge in the field of detonics were heavily dependent upon developments in high speed photography. Nowadays, however, special cameras are available for diagnosing detonation phenomena, and to events caused by high pressure and shock waves, and their commercial development has produced reliable and easy-to-use instruments. Thus, the scientist working on detonics problems can now concentrate on developing measuring techniques instead of developing measuring instrumentation. A short overview will be given of the different most used and important optical equipments and cameras in the field of detonics diagnostics. Further some sophisticated, and even "tricky", configurations for optical high-speed measurements in the field of detonics will be shown in various examples which have recently been in refinded detonation diagnostics.
Food and Pharmaceuticals (2010)

Recently, contamination of pharmaceuticals with diethylene glycol (DEG) and food with melamine and cyanuric acid has demonstrated the impact of globalization on drug and food safety. By examining the details of these outbreaks, some important lessons can be learned. Toxicoses from contaminated food and drugs are often identified only when large numbers of people or animals are affected and numerous deaths result. Populations most at risk are those repeatedly exposed to a single product. Toxicoses may be complex, involving synergism among relatively nontoxic co-contaminants. Although some contamination may occur inadvertently, practices of deliberate contamination of food and drug ingredients may be widespread but escape detection in poorly regulated markets. If this deliberate contamination is motivated by personal financial gain, it is likely to recur and be concealed. The contaminated raw material produced in a poorly regulated market may cross national boundaries and be used in manufacturing processes for numerous products, sometimes in more well-regulated markets. Once in the production chain, contaminated raw materials may be widely disseminated. It is not clear that regulatory organizations have the capacity to identify significant contaminations despite their best efforts. The veterinary and medical communities, in cooperation with regulatory agencies, should develop cooperative programs designed to detect and limit these global outbreaks. Although addressing regional or national outbreaks remains an important role for regulatory agencies, the veterinary and medical communities must develop proactive global approaches to this global problem.
Finding the weakest link in person detectors (2011)

Detecting people remains a popular and challenging problem in computer vision. In this paper, we analyze parts-based models for person detection to determine which components of their pipeline could benefit the most if improved. We accomplish this task by studying numerous detectors formed from combinations of components performed by human subjects and machines. The parts-based model we study can be roughly broken into four components: feature detection, part detection, spatial part scoring and contextual reasoning including non-maximal suppression. Our experiments conclude that part detection is the weakest link for challenging person detection datasets. Non-maximal suppression and context can also significantly boost performance. However, the use of human or machine spatial models does not significantly or consistently affect detection accuracy.
C<scp>ELL</scp>B<scp>IOLOGY OF THE</scp>P<scp>RESYNAPTIC</scp>T<scp>ERMINAL</scp> (2003)

The chemical synapse is a specialized intercellular junction that operates nearly autonomously to allow rapid, specific, and local communication between neurons. Focusing our attention on the presynaptic terminal, we review the current understanding of how synaptic morphology is maintained and then the mechanisms in synaptic vesicle exocytosis and recycling.
Heterojunction bipolar transistors with emitter barrier lowered by /spl delta/-doping (1994)

An npn heterojunction bipolar transistor with a Si-/spl delta/-doped layer at the emitter-base hetero-interface is demonstrated. The Si /spl delta/-doped layer reduces the potential spike at the emitter junction. This design reserves the abruptness of the heterojunction, reduces electron barrier and increases the hole barrier simultaneously. Experimental results show that the HBT's turn-on characteristics are greatly improved while the current gain remains high. The offset voltages as low as 44 mV have been obtained. Very high current gains at very low collector current densities are obtained.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Expression of insulin‐like growth factor‐IA and factor‐IB mRNA in human liver, hepatoma cells, macrophage‐like cells and fibroblast (1991)

The human insulin-like growth factor-I (IGF-I) gene codes for two transcripts, IGF-IA and IGF-IB mRNAs, formed by alternative splicing. In this study, the expression of these IGF-I mRNA transcripts was examined using human liver, hepatoma cells, macrophage-like cells and fibroblasts. The reverse transcription-polymerase chain reaction revealed that these cells contained both IGF-IA mRNA (representing exons I, II, III and V) and IGF-IB mRNA (representing exons I, II, III and IV). Interestingly, an RNase protection assay using 32P-labeled IGF-IA and IGF-IB exon-specific cRNA probes demonstrated that IGF-IA mRNA was 10-fold more abundant than IGF-IB mRNA in these cells. However, there was no difference in the stabilities of IGF-IA and IGF-IB mRNAs. These observations indicate that IGF-IA mRNA is more expressed than IGF-IB mRNA in these cells independent of their stabilities.
Dynamic 3D models with local and global deformations: deformable superquadrics (2002)

A physically-based approach is presented to fitting complex 3D shapes using a novel class of dynamic models. These models can deform both locally and globally. The authors formulate deformable superquadrics which incorporate the global shape parameters of a conventional superellipsoid with the local degrees of freedom of a spline. The local/global representational power of a deformable superquadric simultaneously satisfies the conflicting requirements of shape reconstruction and shape recognition. The model's six global deformational degrees of freedom capture gross shape features from visual data and provide salient part descriptors for efficient indexing into a database of stored models. Model fitting experiments involving 2D monocular image data and 3D range data are reported.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Impact of sphingomyelin levels on coronary heart disease and left ventricular systolic function in humans (2011)

Sphingomyelin (SM) is an abundant phospholipid in cell membranes and in lipoproteins. In human plasma, SM is mainly found in atherogenic lipoproteins; therefore, higher levels of SM may promote atherogenesis. We investigated the relations between plasma SM levels and the presence of angiographic coronary heart disease (CHD) and left ventricular systolic dysfunction. We studied 732 patients referred for coronary angiography. Median SM levels were higher among patients with CHD and in those with LV systolic dysfunction (LVEF<50%) than in patients without CHD or LV dysfunction. SM levels were significantly correlated with fibrinogen levels, diabetes, apoB, and triglyceride levels. On multivariate analyses, higher median SM levels were associated with a higher risk of CHD and lower LV ejection fraction. The pro-atherogenic property of plasma SM might be related to 1) CHD; 2) LV systolic dysfunction; and 3) metabolism of apoB-containing or triglyceride-rich lipoproteins.
DISOMIC AND DITELOSOMIC ADDITIONS OF DIPLOID<i>AGROPYRON ELONGATUM</i>CHROMOSOMES TO<i>TRITICUM AESTIVUM</i> (1974)

A set of disomic addition lines was produced in which each chromosome of Agropyron elongatum (2n = 14) was added to the chromosome complement of Triticum aestivum cv. Chinese Spring. In addition a complete set of ditelosomic addition lines involving Agropyron chromosome arms IS, IIα, IIIα, IVS, IVL, VS, VL, VIS and VIIα, was developed. Except for disomic addition line VII which is similar to Chinese Spring, each added alien chromosome pair was found to have a specific effect on plant morphology. Five disomic addition lines had reduced fertility. Agropyron chromosome arms carrying genes for anthocyanin production, waxless foliage, tenacious glumes, and several other traits were identified. The single Agropyron chromosomes in the monosomic addition lines usually have either minor effects or no effect on plant morphology and fertility.The disomic addition lines are similar in many characters to tetrasomics of the corresponding homoeologous wheat chromosomes and show characters that are not present in either Ag. elongatum or the amphiploid, T. aestivum × Ag. elongatum. Thus many of the effects are due to gene dosage. If individual disomic addition lines are compared with the amphiploid a significant role of interchromosomal gene interactions is apparent.In combination with knowledge of the homoeologous relationships among wheat and alien chromosomes, sets of disomic addition lines can provide valuable information on the evolutionary past of genomes in Triticinae. In monosomic addition lines only Agropyron chromosome IV paired with a wheat chromosome and it is concluded that it is improbable that Agropyron genomes played any role in the evolution of the polyploid series of Aegilops and Triticum.
A High-Throughput Study in Melanoma Identifies Epithelial-Mesenchymal Transition as a Major Determinant of Metastasis (2007)

Metastatic disease is the primary cause of death in cutaneous malignant melanoma (CMM) patients. To understand the mechanisms of CMM metastasis and identify potential predictive markers, we analyzed gene-expression profiles of 34 vertical growth phase melanoma cases using cDNA microarrays. All patients had a minimum follow-up of 36 months. Twenty-one cases developed nodal metastatic disease and 13 did not. Comparison of gene expression profiling of metastatic and nonmetastatic melanoma cases identified 243 genes with a >2-fold differential expression ratio and a false discovery rate of <0.2 (206 up-regulated and 37 down-regulated). This set of genes included molecules involved in cell cycle and apoptosis regulation, epithelial-mesenchymal transition (EMT), signal transduction, nucleic acid binding and transcription, protein synthesis and degradation, metabolism, and a specific group of melanoma- and neural-related proteins. Validation of these expression data in an independent series of melanomas using tissue microarrays confirmed that the expression of a set of proteins included in the EMT group (N-cadherin, osteopontin, and SPARC/osteonectin) were significantly associated with metastasis development. Our results suggest that EMT-related genes contribute to the promotion of the metastatic phenotype in primary CMM by supporting specific adhesive, invasive, and migratory properties. These data give a better understanding of the biology of this aggressive tumor and may provide new prognostic and patient stratification markers in addition to potential therapeutic targets.
[Circadian rhythms and light responses of clock gene and arylalkylamine N-acetyltransferase gene expressions in the pineal gland of rats]. (2005)

This study was to investigate the circadian rhythms and light responses of Clock gene and arylalkylamine N-acetyltransferase (NAT) gene expressions in the rat pineal gland under the 12 h-light : 12 h-dark cycle condition (LD) and constant darkness (DD). Sprague-Dawley rats housed under the light regime of LD (n=36) for 4 weeks and of DD (n=36) for 8 weeks were sampled for the pineal gland once a group (n=6) every 4 h in a circadian day. The total RNA was extracted from each sample and the semiquantitative reverse transcription polymerase chain reaction (RT-PCR) was used to determine the temporal changes in mRNA levels of Clock and NAT genes during different circadian times or zeitgeber times. The data were analysed by the cosine function software, Clock Lab software and the amplitude F test was used to reveal the circadian rhythm. The main results obtained are as follows. (1) In DD or LD condition, both of Clock and NAT genes mRNA levels in the pineal gland showed robust circadian oscillation (P< 0.05) with the peak at the subjective night or at night-time. (2) In comparison with DD regime, the amplitudes and the mRNA levels at peaks of Clock and NAT genes expressions in LD in the pineal gland were significantly reduced (P< 0.05). (3) In DD or LD condition, the circadian expressions of NAT gene were similar in pattern to those of Clock gene in the pineal gland (P> 0.05). These findings suggest that the expressions of Clock and NAT genes in the pineal gland not only show remarkably synchronous endogenous circadian rhythmic changes, but also response to the ambient light signal in a reduced manner.
Phosphodiesterase-5 inhibitors and benign prostatic hyperplasia (2009)

There has been increasing interest in the use of PDE5 inhibitors to treat BPH/LUTS. Combination of PDE5 inhibitors and alpha1-adrenergic blockers may have an additive beneficial effect on BPH/LUTS compared with monotherapy. Mechanisms of action of nitric oxide/cyclic guanosine monophosphate/PDE5 pathway in the treatment of BPH/LUTS deserve further investigations. Larger-scale, well designed clinical trials in future are needed to ascertain the safety, efficacy and cost-effectiveness of PDE5 inhibitors in the treatment of LUTS secondary to BPH.
Resistive switching in aluminum/anodized aluminum film structure without forming process (2009)

Metal-insulator-metal (MIM) structure was fabricated by partially anodizing aluminum film followed by deposition of another aluminum film. Unipolar resistive switching between a high-resistance state and a low-resistance state with a high resistance ratio (&gt;∼104) was observed from the structure. The switching occurred without the requirement of a forming process, which was attributed to the pre-existing conductive filaments in the Al-rich AlxOy layer formed by the anodization. Each resistance state exhibited Ohmic behavior which could be explained by the metallic conduction and electron hopping from one isolated state to the next in the Al-rich AlxOy layer. The MIM structure showed good memory characteristics.
On the Detection of Persistent Attacks using Alert Graphs and Event Feature Embeddings (2020)

Intrusion Detection Systems (IDS) generate a high volume of alerts that security analysts do not have the resources to explore fully. Modelling attacks, especially the coordinated campaigns of Advanced Persistent Threats (APTs), in a visually-interpretable way is a useful approach for network security. Graph models combine multiple alerts and are well suited for visualization and interpretation, increasing security effectiveness. In this paper, we use feature embeddings, learned from network event logs, and community detection to construct and segment alert graphs of related alerts and networks hosts. We posit that such graphs can aid security analysts in investigating alerts and may capture multiple aspects of an APT attack. The eventual goal of this approach is to construct interpretable attack graphs and extract causality information to identify coordinated attacks.
Site‐<scp>S</scp>pecific Gene Targeting Using Transcription Activator‐<scp>L</scp>ike Effector (<scp>TALE</scp>)‐<scp>B</scp>ased Nuclease in <i>Brassica oleracea</i> (2013)

Site-specific recognition modules with DNA nuclease have tremendous potential as molecular tools for genome targeting. The type III transcription activator-like effectors (TALEs) contain a DNA binding domain consisting of tandem repeats that can be engineered to bind user-defined specific DNA sequences. We demonstrated that customized TALE-based nucleases (TALENs), constructed using a method called "unit assembly", specifically target the endogenous FRIGIDA gene in Brassica oleracea L. var. capitata L. The results indicate that the TALENs bound to the target site and cleaved double-strand DNA in vitro and in vivo, whereas the effector binding elements have a 23 bp spacer. The T7 endonuclease I assay and sequencing data show that TALENs made double-strand breaks, which were repaired by a non-homologous end-joining pathway within the target sequence. These data show the feasibility of applying customized TALENs to target and modify the genome with deletions in those organisms that are still in lacking gene target methods to provide germplasms in breeding improvement.
Reduction of Polymers Using Complex Metal Hydrides (1959)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReduction of Polymers Using Complex Metal HydridesH. L. COHEN and L. M. MINSKCite this: J. Org. Chem. 1959, 24, 10, 1404–1407Publication Date (Print):October 1, 1959Publication History Published online1 May 2002Published inissue 1 October 1959https://pubs.acs.org/doi/10.1021/jo01092a003https://doi.org/10.1021/jo01092a003research-articleACS PublicationsRequest reuse permissionsArticle Views180Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Studies on Cerebral Protective Agents. I. Novel 4-Arylpyrimidine Derivatives with Anti-anoxic and Anti-lipid Peroxidation Activities. (1992)

Novel 4-arylpyrimidine derivatives were synthesized by the oxidation of 4-aryl-1,4-dihydropyrimidines, and their effects on anti-anoxic (AA) activity in mice and anti-lipid peroxidation (ALP) activity in rat brain mitochondria were investigated. Among these compounds, ethyl 6-methyl-2-phenyl-4-(4-pyridyl)-5-pyrimidinecarboxylate (4b) has AA activity (10 mg/kg, i.p.) and ethyl 6-methyl-4-(3-nitrophenyl)-2-phenyl-5-pyrimidinecarboxylate (4f) has ALP activity (73% inhibition at 10(-5) g/ml). The latter compound (100 mg/kg, i.p.) was also effective on arachidonate-induced cerebral edema in rats with comparable potency to that of vitamin E.
High-Performance Resource Allocation and Request Redirection Algorithms for Web Clusters (2008)

With increasing richness in features such as personalization of content, Web applications are becoming increasingly complex and hence compute intensive. Traditional approaches for improving performance of static content Web sites have been based on the assumption that static content such as images are network intensive. However, these methods are not applicable to the dynamic content applications which are more compute intensive than static content. This paper proposes a suite of algorithms which jointly optimize the performance of dynamic content applications by reducing the client access times while also minimizing the resource utilization. A server migration algorithm allocates servers on-demand within a cluster such that the client access times are not affected even under sudden overload conditions. Further, a server selection mechanism enables statistical multiplexing of resources across clusters by redirecting requests away from overloaded clusters. We also propose a cluster decision algorithm which decides whether to migrate in additional servers at the local cluster or redirect requests remotely under different workload conditions. Through a combination of analytical modeling, trace-driven simulation over traces from large e-commerce sites and testbed implementation, we explore the performance savings achieved by the proposed algorithms.
A new multiple subtraction method using the attributes of predicted multiples (2008)

Despite the development of excellent techniques for predicting multiples such as convolution based or wavefield extrapolation based approaches, subtracting multiples in the data using the predicted multiples still remains as a challenge. The difficulty stems from the fact that many existing techniques try to match the predicted multiples to the multiples in the data by either adaptation or pattern matching. Because the prediction techniques mentioned above change the waveform of the predicted multiples, it will be very difficult to perfectly match the waveform of the predicted multiples to that of the multiples in the data. We report a new technique for subtracting the multiples using the attributes of the predicted multiples to determine the multiples in the data without any matching process. We illustrate the technique using a synthetic data set and show 3‐D field data examples.
Growth of GaN(0001)1×1 on Al2O3(0001) by gas-source molecular beam epitaxy (1992)

Gas-source molecular beam epitaxy (GSMBE), utilizing Ga and NH3, has been used to grow single-crystal GaN(0001)1×1 on Al2O3(0001) substrates at temperatures Ts between 700 and 850 °C. In situ reflection high-energy electron diffraction studies show a transition from three-dimensional to two-dimensional growth at Ts≳770 °C. For ≂1-μm-thick GaN layers, the best room-temperature carrier mobilities, 100–110 cm2 V−1 s−1, with carrier concentrations of 1–4×1018 cm−3, were obtained at Ts≥780 °C. These are the highest reported mobilities for MBE GaN. Band-to-band photoluminescence was observed in these films at room temperature. Cross-sectional transmission electron microscopy showed that the primary defects in the films were threading dislocations, with Burgers vectors a0/3〈21̄1̄0〉, and stacking faults.
Low-Molecular-Weight Heparin for the Treatment of Acute Ischemic Stroke (1995)

For patients with ischemic stroke treated within 48 hours of the onset of symptoms, low-molecular-weight heparin was effective in improving outcomes at six months.