gebhart/patrepeval huggingface dataset:
A likely molecular basis of the susceptibility of <i>Giardia lamblia</i> Towards oxygen (2005)

Giardia lamblia is an amitochondrial protozoan susceptible to oxygen, but the molecular basis for it remains unclear. A Giardia NAD(P)H:menadione oxidoreductase (DT-diaphorase) is known to catalyse a single electron transfer reaction with quinones as the likely two-electron acceptor when oxygen is absent. Here we overexpressed this enzyme in Giardia trophozoites and observed a significantly enhanced susceptibility of the cells towards oxygen. A knock-down of this enzyme resulted, however, in more oxygen-tolerant Giardia cells growing equally well under anaerobic and aerobic conditions. The function of DT-diaphorase could be thus a major, if not the only, cause for the oxygen susceptibility of Giardia. Overexpressed DT-diaphorase is accompanied by increased intracellular hydrogen peroxide. An overexpression of Fe-superoxide dismutase in Giardia led also to a similarly heightened sensitivity to oxygen. Thus, generation of H2O2 from superoxide anion likely produced from DT-diaphorase catalysed reaction using oxygen as electron acceptor may constitute the molecular basis for Giardia susceptibility to oxygen. A functional homologue of DT-diaphorase in Giardia, NADH oxidase, uses oxygen as the preferred electron acceptor and reduces it to water. Overexpression of this enzyme in Giardia resulted in significantly enhanced growth under aerobic conditions. Giardia NADH oxidase could be thus an instrumental enzyme for the organism to adapt to and to tolerate an aerobic living environment.
Hydrous Sodium Titanate Ion-Exchange Materials for Use as Catalyst Supports (1989)

Understanding how the activity of a catalyst is related to the concentration and dispersion of active metals on the catalyst support is critical to designing materials having the optimum catalytic properties. We have developed synthetic techniques for controlling both the concentration and dispersion of nickel on hydrous sodium titanate catalyst supports. The techniques require an understanding of the solution chemistry of both the support material and dissolved metal species (hydrolysis products). In this paper, we present the results of a study of three nickel-loaded samples of hydrous sodium titanate in which the scale of the nickel dispersion ranges from the atomic level to the scale of large (50 nm) clusters. The catalysts are characterized by transmission electron microscopy (TEM), hydrogen chemisorption, and BET surface area measurements. In addition, the activity and selectivity of the Ni catalysts for the n-butane hydrogenolysis reaction is used to monitor the surface structures of Ni in the catalysts.
Managing a digital library of legislation (1997)

Article Free Access Share on Managing a digital library of legislation Authors: Timothy Arnold-Moore Multimedia Database Systems, RMIT Multimedia Database Systems, RMITView Profile , Philip Anderson Multimedia Database Systems, RMIT Multimedia Database Systems, RMITView Profile , Ron Sacks-Davis Multimedia Database Systems, RMIT Multimedia Database Systems, RMITView Profile Authors Info & Claims DL '97: Proceedings of the second ACM international conference on Digital librariesJuly 1997 Pages 175–183https://doi.org/10.1145/263690.263812Published:01 July 1997Publication History 5citation432DownloadsMetricsTotal Citations5Total Downloads432Last 12 Months15Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Hemopexin and haptoglobin: allies against heme toxicity from hemoglobin not contenders (2015)

The goal here is to describe our current understanding of heme metabolism and the deleterious effects of "free" heme on immunological processes, endothelial function, systemic inflammation, and various end-organ tissues (e.g., kidney, lung, liver, etc.), with particular attention paid to the role of hemopexin (HPX). Because heme toxicity is the impetus for much of the pathology in sepsis, sickle cell disease (SCD), and other hemolytic conditions, the biological importance and clinical relevance of HPX, the predominant heme binding protein, is reinforced. A perspective on the function of HPX and haptoglobin (Hp) is presented, updating how these two proteins and their respective receptors act simultaneously to protect the body in clinical conditions that entail hemolysis and/or systemic intravascular (IVH) inflammation. Evidence from longitudinal studies in patients supports that HPX plays a Hp-independent role in genetic and non-genetic hemolytic diseases without the need for global Hp depletion. Evidence also supports that HPX has an important role in the prognosis of complex illnesses characterized predominantly by the presence of hemolysis, such as SCD, sepsis, hemolytic-uremic syndrome, and conditions involving IVH and extravascular hemolysis (EVH), such as that generated by extracorporeal circulation during cardiopulmonary bypass (CPB) and from blood transfusions. We propose that quantitating the amounts of plasma heme, HPX, Hb-Hp, heme-HPX, and heme-albumin levels in various disease states may aid in the diagnosis and treatment of the above-mentioned conditions, which is crucial to developing targeted plasma protein supplementation (i.e., "replenishment") therapies for patients with heme toxicity due to HPX depletion.
Novel Pd(II)- and Pt(II)-Catalyzed Regio- and Stereoselective <i>trans</i>-Hydroarylation of Alkynes by Simple Arenes (2000)

Efficient trans-hydroarylation of alkynes by simple arenes has been realized regio- and stereoselectively at room temperature in the presence of Pd(II) or Pt(II) catalysts and a mixed solvent containing trifluoroacetic acid (TFA). Various arenes undergo trans-hydroarylation selectively across terminal and internal C−C triple bondsincluding those conjugated to CHO, COMe, CO2H, and CO2Et groups, affording kinetically controlled cis-arylalkenes predominantly in most cases, especially, in good yields for electron-rich arenes and activated alkynes. The formation of arene/alkyne 1/2 or 2/1 adducts as side products is dependent on the arenes' and alkynes' substituents, which can be suppressed in some cases by changing the catalyst, catalyst concentration, and reaction time. The Pt(II) system, PtCl2/2AgOAc/TFA, shows lower catalytic activity than Pd(OAc)2/TFA, but higher selectivity, giving higher yields of adducts at the same conversion. On the basis of several isotope experiments and control reactions, a possible mechanism involving electrophilic metalation of aromatic C−H bonds by in-situ-generated cationic Pd(II) and Pt(II) species leading to intermolecular trans-arylpalladation to alkynes has been discussed.
A two-step implanted base (TSIB) process for high-performance bipolar transistor (1992)

The fabrication process, device profiles, and electrical characteristics of an advanced bipolar transistor with a two-step ion-implanted base (TSIB) are described. This base implant scheme has achieved a significant collector-emitter leakage yield improvement over the conventional transistor (control) which does not receive the TSIB implant. The TSIB base profile can be kept almost identical to that of the control transistors by using the selective implanted collector process. The maximum cutoff frequency of 20 GHz is measured.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Improving Face Recognition via Narrowband Spectral Range Selection Using Jeffrey Divergence (2009)

In order to achieve improved recognition performance in comparison with conventional broadband images, this paper addresses a new method that automatically specifies the optimal spectral range for multispectral face images according to given illuminations. The novelty of our method lies in the introduction of a distribution separation measure and the selection of the optimal spectral range by ranking these separation values. The selected spectral ranges are consistent with the physics analysis of the multispectral imaging process. The fused images from these chosen spectral ranges are verified to outperform the conventional broadband images by 3%-20%, based on a variety of experiments with indoor and outdoor illuminations using two well-recognized face-recognition engines. Our discovery can be practically used for a new customized sensor design associated with given illuminations for improved face-recognition performance over the conventional broadband images.
Development of web service and comparative analysis of university survey data (2012)

This paper describes the state of research for web service development of university survey data and comparative analysis on the survey data with consideration of general university information structure. Institution data of university, college, or college of technology are substantially important for data analysis or knowledge discovery in education management field. However, university institution data are not necessarily standardized and compiled in each university, so that it is not easy to integrate their information for various analyses. Investigation of the integrated university database is needed to deal with various kinds of university institution information including national university survey or school basic survey in Japan, providing the structured university data via web services, some of which can be utilized for analyses of university characteristics.
Novel nonlinear representation for two-stage power-factor-correction converter instability (2004)

Two-stage power-factor-correction (PFC) converter is the most common circuit to draw sinusoidal and in phase current waveforms from the ac source with a good regulated output voltage. The first stage is the boost PFC converter with average-current-mode control for achieving the near-unity power factor and the second stage is the forward converter with voltage-mode control for the purpose of a regulated output voltage. Stability analysis and design method were discussed depending on the linear models. Recently, new; nonlinear phenomena have been detected in PFC circuits and a new nonlinear model has been proposed for the pre-regulated PFC converter. Therefore, this paper introduces a study for stability of two-stage PFC converter. A novel nonlinear model for two-stage PFC converter is proposed. Then, stability analysis is studied depending on this nonlinear model. Simulation and experiment confirm this analysis with a good matching.
B7.2 (CD86) But Not B7.1 (CD80) Costimulation Is Required for the Induction of Low Dose Oral Tolerance (1999)

Oral administration of Ag leads to systemic unresponsiveness (oral tolerance) to the fed Ag. Oral tolerance is mediated through active suppression by Th2 or TGF-beta-secreting cells or clonal anergy/deletion, depending on the Ag dose used, with low dose favoring active suppression and high dose favoring anergy/deletion. The nature of APC and inductive events leading to the generation of oral tolerance have not been well defined. To determine the role of costimulatory molecules in the induction of oral tolerance, we have tested the effect of anti-B7.1 or anti-B7.2 mAb on the induction of tolerance by both high and low dose Ag feeding regimens. Our results show that the B7.2 molecule is critical for the induction of low-dose oral tolerance. Injection of anti-B7.2 but not anti-B7.1 intact Ab or Fab fragments inhibited the oral tolerance induced by low-dose (0.5 mg) but not high-dose OVA (25 mg) feeding. In addition, anti-B7.2, but not anti-B7.1, inhibited secretion of TGF-beta, one of the primary cytokines that mediates low-dose oral tolerance. Finally, in the in vivo model of experimental allergic encephalomyelitis, anti-B7.2 mAb treatment abrogated protection offered against disease by low-dose myelin basic protein feeding, while anti-B7.1 had no effect. Anti B7.2 had no effect on disease suppression by high-dose oral Ag. These data demonstrate that B7.2 costimulatory molecules play an essential role in the induction of low-dose oral tolerance.
Effects of pressurization procedures on calibration results for precise pressure transducers (2010)

The output of electromechanical pressure gauges depends on not only the currently applied pressure, but also the pressurization history. Thus, the calibration results of gauges are affected by the pressurization procedure. In this paper, among several important factors influencing the results, we report the effects of the interval between the calibration cycles and the effects of the preliminary pressurizations. In order to quantitatively evaluate these effects, we developed a fully automated system that uses a pressure balance to calibrate pressure gauges. Subsequently, gauges containing quartz Bourdon-type pressure transducers were calibrated in a stepwise manner for pressures between 10 MPa and 100 MPa. The typical standard deviation of the data over three cycles was reduced to a few parts per million (ppm). The interval between the calibration cycles, which ranges from zero to more than 12 h, exerts a strong influence on the results in the process of increasing the pressure, where at 10 MPa the maximum difference between the results was approximately 40 ppm. The preliminary pressurization immediately before the calibration cycle reduces the effects of the interval on the results in certain cases. However, in turn, the influence of the waiting time between the preliminary pressurization and the main calibration cycle becomes strong. In the present paper, we outline several possible measures for obtaining calibration results with high reproducibility.
题名 整合主板也玩双显卡 NVIDIA新武器混合SLI技术 (2007)

串烧背景：Hybrid SLI将于10月面世 NVIDIA最近透露出来的“Hybrid SLI Technology”（混合SLI技术）,通过该技术整合图形核心将能够和独立显卡组建SLI系统,
GSM EFR based multi-rate codec family (2002)

This paper describes a multi-rate codec family developed as a potential candidate for the GSM adaptive multi-rate (AMR) codec standard. The codec family consists of the GSM enhanced full rate (EFR) codec and lower bit-rate extensions thereof. The codec family consists of several codecs, i.e., modes that have different bit-rate partitionings between source coding and error protection. All the source codecs use the same ACELP-method (algebraic code excited linear predictive coding) used also in the GSM EFR codec. The codec operates at gross bit-rates of 22.8 kbit/s in the GSM full rate (FR) channel and 11.4 kbit/s in the GSM half rate (HR) channel. In the full rate channel, the codec provides improved error robustness over the GSM enhanced full rate (EFR) codec. It extends wireline quality (equal to or better than G.726-32 ADPCM) to poor channel error conditions with low C/I-ratios of 7 dB or even below. When operated in the half rate channel, the codec provides improved channel capacity while still providing wireline quality at high C/I-ratios above 16-19 dB.
Expression patterns of WT-1 and Bcr-Abl measured by TaqMan quantitative real-time RT-PCR during follow-up of leukemia patients with the Ph chromosome. (2004)

WT-1 expression provides a novel molecular marker in addition to Bcr-Abl for monitoring minimal residual disease (MRD) and targeting therapy in Ph chromosome-positive leukemia patients.
Overload Control Method for Synchronized MTC Traffic in GERAN (2011)

Increasing attention has been drawn in Machine Type Communications (MTC), also known as Machine to Machine (M2M) Communications, since it enables implementation of new services, and expansion of revenue sources for mobile equipment manufacturers and mobile network operators. This potential is high, but some issues have to be solved to enable the wide application of MTC services, especially those which could request connections in a synchronized manner. In GSM networks, synchronized channel requests can result in signaling channel overload, which would delay the access procedure for all users trying to access the network. This paper presents a solution for this problem, in which devices connecting in a periodical manner request a future network access already during a previous connection. Simulation results have shown that by using this technique, overload on the access channels is reduced, improving the access delay of normal users and enabling more MTC devices to be included in the network.
Growth of SiC using hexamethyldisilane in a hydrogen-poor ambient (1994)

Growth of cubic SiC has been carried out on Si(111), Si(100), and SiC(0001) substrates using chemical vapor deposition at atmospheric pressure. Hexamethyldisilane (HMDS) was used as the only precursor and pure Ar or a nonflammable mixture of Ar and H2 was used as the carrier gas. The crystallinity was characterized by x-ray diffraction, reflection high energy electron diffraction (RHEED), and transmission electron microscopy. It was found that polycrystalline layers were obtained at low growth temperatures and with pure Ar as the carrier gas, while the crystallinity improved at temperatures above 1300 °C and when H2 was added. Under optimum growth conditions most of the grains are oriented with parallel epitaxy or with twinned epitaxy with respect to an (111) substrate. A Si/SiC heterodiode was also grown and it shows a breakdown voltage of more than 100 V.
Super-Resolution Based on Sparse Dictionary Coding (2012)

基于学习的超分辨率方法通常根据低分辨率图像从样本库中选取若干特征相似的匹配对象,再使用优化算法进行超分辨率估计,但其结果受匹配对象的质量限制,并且匹配特征一般只选择图像的几何结构信息,匹配准确性较低.提出了稀疏字典编码的超分辨率模型,将高、低分辨率图像特征块统一进行稀疏编码,建立高、低分辨率图像的稀疏关联,同步实现匹配搜索和优化估计,突破了上述方法的限制.应用形态分量分析法提取图像的特征数据,提高了特征匹配的准确性,并同步实现超分辨率重建和降噪功能.优化方法采用稀疏K-SVD算法以提高稀疏字典编码的计算速度.采用自然图像进行实验,与其他基于学习的超分辨率算法相比,重建所得到的图像质量更优.
H<sub>2</sub>-rich fluids from serpentinization: Geochemical and biotic implications (2004)

Metamorphic hydration and oxidation of ultramafic rocks produces serpentinites, composed of serpentine group minerals and varying amounts of brucite, magnetite, and/or FeNi alloys. These minerals buffer metamorphic fluids to extremely reducing conditions that are capable of producing hydrogen gas. Awaruite, FeNi3, forms early in this process when the serpentinite minerals are Fe-rich. Olivine with the current mantle Fe/Mg ratio was oxidized during serpentinization after the Moon-forming impact. This process formed some of the ferric iron in the Earth's mantle. For the rest of Earth's history, serpentinites covered only a small fraction of the Earth's surface but were an important prebiotic and biotic environment. Extant methanogens react H2 with CO2 to form methane. This is a likely habitable environment on large silicate planets. The catalytic properties of FeNi3 allow complex organic compounds to form within serpentinite and, when mixed with atmospherically produced complex organic matter and waters that circulated through basalts, constitutes an attractive prebiotic substrate. Conversely, inorganic catalysis of methane by FeNi3 competes with nascent and extant life.
Fast CG-Based Methods for Tikhonov--Phillips Regularization (1999)

Tikhonov--Phillips regularization is one of the best-known regularization methods for inverse problems. A posteriori criteria for determining the regularization parameter $\alpha$ require solving $$(*) (A^*A+\alpha I) x =A^* y^{\delta}$$ for different values of $\alpha$. We investigate two methods for accelerating the standard cg-algorithm for solving the family of systems (*). The first one utilizes a stopping criterion for the cg-iterations which depends on $\alpha$ and $\delta$. The second method exploits the shifted structure of the linear systems (*), which allows us to solve (*) simultaneously for different values of $\alpha$. We present numerical experiments for three test problems which illustrate the practical efficiency of the new methods. The experiments as well as theoretical considerations show that run times are accelerated by a factor of at least 3.
Encuentro de los Visitadores: “Animación de Comunidades Locales” All Hallows College-Dublin (4 - 16 junio de 2001) (2002)

Encuentro de los Visitadores: "Animacin
El desafío de encontrar estrategias motivadoras para los millennials en el proceso de enseñanza aprendizaje (2018)

La educacion, y en especial la educacion superior, se enfrentan a un desafio de epoca; es muy evidente la diferencia generacional entre alumnos y docentes. Los jovenes de hoy, con frecuencia, buscan carreras cortas que les permitan una salida laboral rapida y efectiva, incluso en espacios no formales, en algunos casos bastante lejos de la tradicional oferta educativa, en espacios que logran entender los nuevos paradigmas de aproximacion al conocimiento y su apropiacion. Surgen entonces algunos interrogantes, por ejemplo: ?cuales son las generaciones que actualmente conviven en el proceso de ensenanza–aprendizaje? ?Entendemos las motivaciones de estas nuevas generaciones de estudiantes, su forma de estudiar, de interactuar, de colaborar, de crear? La convivencia multigeneracional ciertamente plantea la necesidad de comunicarse segun las formas que para los nuevos alumnos son naturales. Esto tiene fuerte impacto en el ambito educativo, en particular en las estrategias a implementar en el proceso de ensenanza aprendizaje; de su exito depende que los estudiantes alcancen un desarrollo satisfactorio en su profesion y en la contribucion de estos con la sociedad. Es asi que, teniendo en cuenta el apego que tienen los millennials a la tecnologia, y en especial a los smartphones, se utilizaran estos como el centro de comunicaciones que permitira llegar directamente y en todo momento a los estudiantes. Para ellos es mucho mas natural recibir las “novedades” en su dispositivo, que ingresar a cada una de las plataformas o recursos que se ponen a su disposicion. En esta intervencion se describen algunas herramientas que se consideran apropiadas para la mejora del proceso de ensenanza–aprendizaje, ya que se estima permitiran que los estudiantes logren ser verdaderos gestores del conocimiento, tanto en su vida profesional como personal. El objetivo es ayudar a formar personas integras que se desempenen con responsabilidad social en todos los aspectos de su quehacer diario, en definitiva, que logren ser felices construyendo su futuro.
Glutathione Redox System in <i>β</i>‐Thalassemia/Hb E Patients (2013)

β -thalassemia/Hb E is known to cause oxidative stress induced by iron overload. The glutathione system is the major endogenous antioxidant that protects animal cells from oxidative damage. This study aimed to determine the effect of disease state and splenectomy on redox status expressed by whole blood glutathione (GSH)/glutathione disulfide (GSSG) and also to evaluate glutathione-related responses to oxidation in β -thalassemia/Hb E patients. Twenty-seven normal subjects and 25 β -thalassemia/Hb E patients were recruited and blood was collected. The GSH/GSSG ratio, activities of glutathione-related enzymes, hematological parameters, and serum ferritin levels were determined in individuals. Patients had high iron-induced oxidative stress, shown as significantly increased serum ferritin, a decreased GSH/GSSG ratio, and increased activities of glutathione-related enzymes. Splenectomy increased serum ferritin levels and decreased GSH levels concomitant with unchanged glutathione-related enzyme activities. The redox ratio had a positive correlation with hemoglobin levels and negative correlation with levels of serum ferritin. The glutathione system may be the body's first-line defense used against oxidative stress and to maintain redox homeostasis in thalassemic patients based on the significant correlations between the GSH/GSSH ratio and degree of anemia or body iron stores.