gebhart/patrepeval huggingface dataset:
Development of a plastic encapsulated multichip technology for high volume, low cost commercial electronics (1995)

Non-military/noncomputer electronics industry segments such as PC's, workstations, portable electronics, the automotive and medical industries, automated test equipment, and high-end consumer goods, are evolving rapidly. They demand higher complexity and higher performance circuits and components. At the same time, many of these industry segments are being driven to shrink size, weight, and power dissipation. Standard low cost packaging approaches such as thru-hole PCB and chip and wire hybrids, can no longer efficiently interconnect these more complex circuits. These industry segments are being forced to turn to new higher performance packaging approaches such as SMT, MCM, and COB. This paper describes an innovative embedded chip MCM technology that eliminates high cost structures, as well as materials and processes in current thin film MCM technologies. A plastic encapsulated multichip technology has been developed in which an epoxy encapsulant is molded around bare die to form the MCM substrate. This new MCM process readily scales-up to high volume production and is inherently high yielding, while maintaining all of the performance advantages of the GE developed overlay HDI process. This paper describes the thermal, mechanical, and chemical stability issues that drove this development, the process used to fabricate the modules, and the cost and yield advantages associated with this structure.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Effect of Oxygenation on Xylose Fermentation by <i>Pichia stipitis</i> (1990)

The effect of oxygen limitation on xylose fermentation by Pichia stipitis (CBS 6054) was investigated in continuous culture. The maximum specific ethanol productivity (0.20 g of ethanol g dry weight h) and ethanol yield (0.48 g/g) was reached at an oxygen transfer rate below 1 mmol/liter per h. In the studied range of oxygenation, the xylose reductase (EC 1.1.1.21) and xylitol dehydrogenase (EC 1.1.1.9) activities were constant as well as the ratio between the NADPH and NADH activities of xylose reductase. No xylitol production was found. The pyruvate decarboxylase (EC 4.1.1.1) activity increased and the malate dehydrogenase (EC 1.1.1.37) activity decreased with decreasing oxygenation. With decreasing oxygenation, the intracellular intermediary metabolites sedoheptulose 7-phosphate, glucose 6-phosphate, fructose 1,6-diphosphate, and malate accumulated slightly while pyruvate decreased. The ratio of the xylose uptake rate under aerobic conditions, in contrast to that under anaerobic assay conditions, increased with increasing oxygenation in the culture. The results are discussed in relation to the energy level in the cell, the redox balance, and the mitochondrial function.
Latent infections of sensory ganglia as influenced by phosphonoformate treatment of herpes simplex virus-induced skin infections in hairless mice (1979)

Topical treatment with 3% phosphonoformate of herpes simplex virus type 1 (HSV)-induced skin infections of hairless mice reduced the severity of skin lesions when the treatment was initiated 3 h after virus inoculation in the lumbosacral area or 3 and 24 h after inoculation in the orofacial area. The mortality was significantly reduced in lumbosacral-infected mice and was completely prevented in orofacial-infected mice when the treatment was initiated with a delay of 24 h after virus inoculation. However, phosphonoformate did not prevent the establishment of latent herpes simplex virus type 1 infections in the spinal and trigeminal ganglia, even when treatment was initiated as early as 3 h after infection.
Design of geosynthetic-reinforced earth using equivalent thickness concept (2013)

The paper presents a design methodology for geosynthetic-reinforced earth using equivalent thickness concept. The reinforced earth or reinforced granular fill is placed on soft soil. The granular fill and the soft soil have been idealized by the Pasternak shear layer and a layer of Winkler springs, respectively. Stretched rough elastic membranes represent the geosynthetic reinforcement layers. Plane strain conditions are considered for the loading and reinforced foundation soil system. An iterative finite difference scheme is applied for obtaining the solution. Based on the result of the present study, design charts are also presented.
Factors influencing peripheral nerve stimulation produced inhibition of primate spinothalamic tract cells (1984)

Several factors that influence the inhibition of primate spinothalamic tract (STT) cells produced by repetitive peripheral conditioning stimulation have been studied. Identified STT cells were recorded from the lumbosacral spinal cord in intact, anesthetized monkeys. In addition, presumed STT cells were recorded from unanesthetized, decerebrate or decerebrate, spinalized monkeys; these cells were identified by antidromic activation from the contralateral ventral lateral funiculus of the upper cervical spinal cord. Activity of the STT cells was evoked by electrically stimulating the sural nerve with pulses having an intensity strong enough to activate C fibers. The C fiber evoked STT cell activity was compared before, during and after repetitive conditioning stimuli applied to the tibial nerve for 5 min. By applying repetitive strengths of conditioning stimuli, it was found that the A delta fiber group is the most important for producing inhibition of STT cells, although significant additional effects were also produced by the A alpha beta and C fiber groups. Conditioning stimuli with fixed intensity at different frequencies showed that the higher the frequency the more powerful the inhibition within the range we tested (0.5-20 Hz). The inhibition produced by peripheral nerve stimulation was segmentally organized, so the most effective nerve in producing inhibition amongst those tested was the ipsilateral tibial nerve. The contralateral sciatic nerve, the ipsilateral median nerve and the contralateral median nerve were less effective in that order. The results of the present experiments suggest that the most effective way to produce analgesia by peripheral nerve stimulation would be by high frequency stimulation of a nerve innervating the area from which pain originates with an intensity at least strong enough to activate A delta fibers.
IL-13 inhibits TNF production but potentiates that of IL-6 in vivo and ex vivo in mice (1997)

IL-13 was reported to inhibit the synthesis of various cytokines in vitro, including that of TNF. It has divergent effects on IL-6 production, which is increased in endothelial cells and decreased in monocytes. We studied the effect of IL-13 administration on TNF and IL-6 production in vivo in mice. IL-13 (1 microg/mouse, i.v., 10 min to 6 h before LPS) decreased LPS (100 ng/mouse, i.v.)-induced serum TNF levels by 50%, while it increased the levels of IL-6 by fourfold. IL-13 potentiated IL-1beta (100 ng/mouse, i.v.)-induced serum IL-6 levels as well as IL-1- or LPS-induced serum amyloid A. When blood from IL-13-treated mice was stimulated with LPS in vitro, TNF production was decreased fivefold, and that of IL-6 was slightly decreased. We also cultured in vitro the aorta obtained from IL-13-pretreated mice and found that they produce more IL-6 (up to sevenfold) than aorta from control mice. Little or no TNF could be detected in these samples. Thus, IL-13 in vivo inhibits serum TNF but up-regulates serum IL-6. The differential regulation of IL-6 and TNF together with the results of ex vivo experiments could be explained by hypothesizing that the cellular origins of the two cytokines are different.
Mismatch analysis and direct yield optimization by spec-wise linearization and feasibility-guided search (2002)

We present a new method for mismatch analysis and automatic yield optimization of analog integrated circuits with respect to global, local and operational tolerances. Effectiveness and efficiency of yield estimation and optimization are guaranteed by consideration of feasibility regions and by performance linearization at worst-case points. The proposed methods were successfully applied to two example circuits for an industrial fabrication process.
The Riddle of Ruth Bryan Owen (2017)

Her ancestors helped win America's independence. As a child, she watched House debates with rapt attention, vowing eventually to return to her beloved Capitol building. She gazed out on millions of cheering faces during her father's three presidential campaigns. Her uncle was a governor and vice-presidential nominee, her father the American Secretary of State. She ran the American Women's War Relief Fund alongside future First Lady Lou Hoover and nursed dying Allied soldiers. After establishing herself as Florida's leading female activist, she campaigned for the House of Representatives in 1928, promising to send her district's most exemplary young citizens to Washington on an unparalleled civic pilgrimage.
Next generation of microbial inoculants for agriculture and bioremediation (2016)

In this Crystal Ball we describe the negative effects of the scheme of intensive agriculture of the green revolution technology. To recover the contaminated soils derived from intensive farming is necessary introduce new successful technologies to replace the use of chemical fertilizer and toxic pesticides by organic fertilizers and biological control agents. Our principal speculation is that in a short time authors in the field of PGPB and bioremediation will be expanding the knowledge on the development of different formulations containing super-bacteria or a mixture of super-bacteria able to provide beneficial effect for agriculture and bioremediation.
A Chemical Biology Solution to Problems with Studying Biologically Important but Unstable 9-O-Acetyl Sialic Acids (2016)

9-O-Acetylation is a common natural modification on sialic acids (Sias) that terminate many vertebrate glycan chains. This ester group has striking effects on many biological phenomena, including microbe-host interactions, complement action, regulation of immune responses, sialidase action, cellular apoptosis, and tumor immunology. Despite such findings, 9-O-acetyl sialoglycoconjugates have remained largely understudied, primarily because of marked lability of the 9-O-acetyl group to even small pH variations and/or the action of mammalian or microbial esterases. Our current studies involving 9-O-acetylated sialoglycans on glycan microarrays revealed that even the most careful precautions cannot ensure complete stability of the 9-O-acetyl group. We now demonstrate a simple chemical biology solution to many of these problems by substituting the oxygen atom in the ester with a nitrogen atom, resulting in sialic acids with a chemically and biologically stable 9-N-acetyl group. We present an efficient one-pot multienzyme method to synthesize a sialoglycan containing 9-acetamido-9-deoxy-N-acetylneuraminic acid (Neu5Ac9NAc) and compare it to the one with naturally occurring 9-O-acetyl-N-acetylneuraminic acid (Neu5,9Ac<sub>2</sub>). Conformational resemblance of the two molecules was confirmed by computational molecular dynamics simulations. Microarray studies showed that the Neu5Ac9NAc-sialoglycan is a ligand for viruses naturally recognizing Neu5,9Ac<sub>2</sub>, with a similar affinity but with much improved stability in handling and study. Feeding of Neu5Ac9NAc or Neu5,9Ac<sub>2</sub> to mammalian cells resulted in comparable incorporation and surface expression as well as binding to 9-O-acetyl-Sia-specific viruses. However, cells fed with Neu5Ac9NAc remained resistant to viral esterases and showed a slower turnover. This simple approach opens numerous research opportunities that have heretofore proved intractable.
Antigen‐induced contraction of guinea‐pig isolated trachea: studies with novel inhibitors and antagonists of arachidonic acid metabolites (1988)

1. Responses of antigen-challenged isolated trachea from sensitized guinea-pigs were pharmacologically characterized by use of some novel inhibitors and antagonists of arachidonic acid metabolites. 2. The cyclo-oxygenase inhibitor, indomethacin, prolonged without altering the maximum response to antigen in the absence of the anti-muscarinic agent, atropine, and/or the H1-receptor blocker, mepyramine. In the presence of mepyramine, indomethacin both prolonged and increased the magnitude of the response. The selective (SQ-29548) and non-selective (L-640,035) thromboxane A2 (TXA2) antagonist and the TXA2 synthetase inhibitor, OKY-046, were essentially inactive. 3. Two novel inhibitors of 5-lipoxygenase product formation, AA-861 and L-651,896 produced complete inhibition of the response to antigen on tissues treated with atropine and mepyramine, with or without indomethacin. 4. Equimolar concentrations of the leukotriene D4 (LTD4) receptor antagonists LY-171883 greater than L-649,923 greater than or equal to L-648,051 greater than or equal to FPL-55712 blocked part of the response to antigen on tissues treated with atropine, mepyramine and indomethacin. All compounds tended to block a larger component of the response in the absence of indomethacin. A similar tendency was observed with the potent phosphodiesterase inhibitor, isobutylmethylxanthine (IBMX) but not the less potent phosphodiesterase inhibitor theophylline. 5. These results are consistent with the hypothesis that 5-lipoxygenase products acting on LTD4 receptors play only a minor role in the mediation of the contraction of guinea-pig trachea to antigen challenge. The nature of the residual contractile mediator is unknown; however, it can be completely blocked by the 5-lipoxygenase inhibitors AA-861 and L-651,896 and non-selectively blocked by the phosphodiesterase inhibitor, IBMX and non-selective LTD4 receptor antagonists, such as LY-171883.
β Elimination and sulfite addition as a means of localization and identification of substituted seryl and threonyl residues in proteins and proteoglycans (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTβ Elimination and sulfite addition as a means of localization and identification of substituted seryl and threonyl residues in proteins and proteoglycansD. L. Simpson, Jovan Hranisavljevic, and E. A. DavidsonCite this: Biochemistry 1972, 11, 10, 1849–1856Publication Date (Print):May 9, 1972Publication History Published online1 May 2002Published inissue 9 May 1972https://pubs.acs.org/doi/10.1021/bi00760a019https://doi.org/10.1021/bi00760a019research-articleACS PublicationsRequest reuse permissionsArticle Views85Altmetric-Citations46LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
EMI Reduction in Switched Power Converters Using Frequency Modulation Techniques (2005)

Frequency-modulation techniques have been used to reduce electromagnetic interference (EMI) produced by the clock of digital systems working in the range of hundreds of megahertz. The working principle consists of modulating the original constant clock frequency in order to spread the energy of each single harmonic into a certain frequency band, thus reducing the peak amplitude of EMI at harmonic frequencies. Nowadays, the switching frequency of power converters has increased up to values that make interesting the application of such techniques to reduce EMI emissions due to switching of power circuits. This paper presents the theoretical principles of frequency modulation using deterministic profiles for the modulating function. It shows the effectiveness of such methods in terms of EMI reduction for different modulation profiles and other parameters. The method is compared with other methods using random modulation. Tests carried out on a buck converter are presented for experimental validation of the method. A short discussion on optimal modulation profiles and parameters is also included.
Using differential properties of the green function in seakeeping computational codes (1999)

The Green function of linear time-domain hydrodynamics has been recently proven to satisfy a simple fourth order ordinary differential equation (ODE). As a first application of this remarkable property, the present paper shows how it can be used to evaluate the kernel of the convolution integrals in the BEM solution of seakeeping problems, in the linear time-domain approach. The Green function is obtained by integrating these ODE from one time-step to another instead of being computed by the classical routines. Several Runge-Kutta algorithms were tested and compared; it is shown how an optimal time step can be derived from stability analysis. The CPU-time savings brought by this new method are then evaluated. Numerical results are given for three test cases: the heaving hemisphere, a standard series-60 ship hull, and a TLP offshore platform. Impulse response functions are calculated and Fourier transformed to recover the classical frequency domain hydrodynamic coefficients as a check for validity and accuracy.
Cognitive and Psychomotor Performance During Alcohol Hangover (2010)

The consequences of alcohol consumption have risen high on health and social agendas in recent years. Although much work has focused on the physical problems associated with alcohol use, one theme that has emerged in alcohol research has been a focus on the effects of hangovers on functioning. This brief literature review specifically examines recent empirical investigations of the relationship between alcohol hangover and psychological performance and is tabled as an update to our earlier review of similar research (Stephens et al., 2008). A literature search generated 75 results on hangover and cognition (and synonyms) since the last published review. However, of these, only 4 met all inclusion criteria, such as establishing that BAL (Blood Alcohol Level) was zero at testing. Taking the findings of these newer studies with those that we reviewed previously, there appears to be real evidence of convergence of findings. There are now four rigorous laboratory studies, two less rigorous laboratory studies lacking placebo control and two rigorous naturalistic studies that indicate specific cognitive decrements in attention and memory during the hangover phase of alcohol consumption. Given this convergence, research agendas for increasing understanding of the cognitive effects of alcohol hangover should now switch from studies that routinely assess many cognitive functions to studies assessing the attention and memory deficits of hangover in greater detail.
Efficient Isolation of Wild Strains of Canine Distemper Virus in Vero Cells Expressing Canine SLAM (CD150) and Their Adaptability to Marmoset B95a Cells (2003)

We have previously shown that canine signaling lymphocyte activation molecule (SLAM; also known as CD150) acts as a cellular receptor for canine distemper virus (CDV). In this study, we established Vero cells stably expressing canine SLAM (Vero.DogSLAMtag cells). Viruses were isolated in Vero.DogSLAMtag cells one day after inoculation with spleen samples from five out of seven dogs with distemper. By contrast, virus isolation with reportedly sensitive marmoset B95a cells was only successful from three diseased animals at 7 to 10 days after inoculation, and no virus was recovered from any dogs when Vero cells were used for isolation. The CDV strain isolated in Vero.DogSLAMtag cells did not cause cytopathic effects in B95a and human SLAM-expressing Vero cells, whereas the strain isolated in B95a cells from the same dog did so in canine or human SLAM-expressing Vero cells as well as B95a cells. There were two amino acid differences in the hemagglutinin sequence between these strains. Cell fusion analysis after expression of envelope proteins and vesicular stomatitis virus pseudotype assay showed that their hemagglutinins were responsible for the difference in cell tropism between them. Site-directed mutagenesis indicated that glutamic acid to lysine substitution at position 530 of the hemagglutinin was required for the adaptation to the usage of marmoset SLAM. Our results indicate that Vero cells stably expressing canine SLAM are highly sensitive to CDV in clinical specimens and that only a single amino acid substitution in the hemagglutinin can allow the virus to adapt to marmoset SLAM.
High throughput and large capacity pipelined dynamic search tree on FPGA (2010)

We propose a pipelined Dynamic Search Tree (pDST) on FPGA which offers high throughput for lookup, insert and delete operations as well as the capability to perform in-place incremental updates. Based on the pipelined 2-3 tree data structure, our pDST supports one lookup per clock cycle and maintains tree balance under continual insert and delete operations. A novel buffered update scheme together with a bi-directional linear pipeline allows the pDST to perform one insert or delete operation per O(log N) cycles (N being the tree capacity) without stalling the lookup operations. Nodes at each pipeline stage are allocated and freed by a free-node chaining mechanism which greatly simplifies the memory management circuit. Our prototype implementation of a 15-level, 32-bit key dual-port pDST requires 192 blocks of 36 Kb BRAMs (64%) and 12.8k LUTs (6.3%) on a Virtex 5 LX330 FPGA. The circuit has a maximum capacity of 96k 32-bit keys and clock rate of 135 MHz, supporting 242 million lookups and concurrently 3.97 million inserts or deletes per second.
McSimA+: A manycore simulator with application-level+ simulation and detailed microarchitecture modeling (2013)

With their significant performance and energy advantages, emerging manycore processors have also brought new challenges to the architecture research community. Manycore processors are highly integrated complex system-on-chips with complicated core and uncore subsystems. The core subsystems can consist of a large number of traditional and asymmetric cores. The uncore subsystems have also become unprecedentedly powerful and complex with deeper cache hierarchies, advanced on-chip interconnects, and high-performance memory controllers. In order to conduct research for emerging manycore processor systems, a microarchitecture-level and cycle-level manycore simulation infrastructure is needed. This paper introduces McSimA+, a new timing simulation infrastructure, to meet these needs. McSimA+ models x86based asymmetric manycore microarchitectures in detail for both core and uncore subsystems, including a full spectrum of asymmetric cores from single-threaded to multithreaded and from in-order to out-of-order, sophisticated cache hierarchies, coherence hardware, on-chip interconnects, memory controllers, and main memory. McSimA+ is an application-level+ simulator, offering a middle ground between a full-system simulator and an application-level simulator. Therefore, it enjoys the light weight of an application-level simulator and the full control of threads and processes as in a full-system simulator. This paper also explores an asymmetric clustered manycore architecture that can reduce the thread migration cost to achieve a noticeable performance improvement compared to a state-of-the-art asymmetric manycore architecture.