gebhart/patrepeval huggingface dataset:
Incorporation of a High Concentration of Mineral or Vitamin into Chitosan-Based Films (2004)

Mineral or vitamin E was incorporated into chitosan-based films: 10-200% (w/w chitosan) Gluconal Cal (GC), a mixture of calcium gluconate and lactate; 5-20% zinc lactate (ZL); and 5-20% alpha-tocopheryl acetate (VE) with acetylated monoglyceride (AM). The functionality of film-forming solutions and dried films was analyzed with standard procedures, and mathematical equations were developed to coordinate selected film functionality with the type and concentration of incorporated mineral or vitamin E. GC incorporation significantly increased pH and decreased viscosity of film-forming solutions, but not the addition of ZL or VE. The water barrier property of the films was improved by increasing the concentration of mineral or vitamin E in the film matrix. The tensile strength of the films was more significantly affected by GC or VE addition than film elongation, puncture strength, and puncture deformation. While a major endothermic peak around 200 degrees C was observed in DSC thermograms of chitosan-based films, only 200% GC incorporation altered this endothermic peak. This study demonstrated the capability of chitosan-based film matrix to carry a high concentration of mineral or vitamin E. Such films may be used for wrapping or coating to enhance the nutritional value of foods.
Advances in portable electrospinning devices for <i>in situ</i> delivery of personalized wound care (2019)

Electrospinning and electrospun fibrous assemblies have attracted interest in a variety of biomedical fields including woundcare, tissue engineering and drug delivery, due to the large surface-area-to-volume ratio and high porosity of nanofibrous webs. Normally, wound dressings are manufactured well before the point of care, and then packaged and distributed for use at a later stage. More recently, in situ electrospinning of fibers directly onto wound sites has been proposed as a route to personalized wound dressing manufacture, tailored to the needs of individual patients. Practically, in situ deposition of nanofibers on to a wound could be envisaged using a portable or hand-held electrospinning device that is safe and easy to operate. This review focuses on recent advances in portable electrospinning technology and potential applications in woundcare and regenerative medicine. The main research challenges and future trends are also considered.
Wavelength dependence of intracellular nitric oxide levels in hTERT-RPE cells in vitro (2018)

Photobiomodulation (PBM) refers to the beneficial effects of low doses of light whether mediating therapeutic effects for pathophysiological processes, or stimulating resistance to physiological challenges. While much is known about beneficial outcomes, our understanding of the molecular mechanisms underlying these observed effects is still limited. It has been hypothesized that increases in ATP stimulate downstream signaling through transcription factors. However, it is also known that PBM can induce elevated levels of nitric oxide (NO) in cells, which is thought to occur by release of NO bound to cytochrome-c oxidase (COX). NO is a powerful signaling molecule involved in a host of biological responses; however, the mechanisms of NO production and the role of NO in the PBM response have received little attention. Utilizing human retinal pigmented epithelium cells (RPE) in vitro, coupled with a multi-laser exposure set-up, we have begun to systematically investigate the mechanism of NO production and function in the PBM response. Our data indicates that while NO levels are elevated following single exposures to 447, 532, 635 or 808 nm, the strength of the response is wavelength-dependent, and the response can be modulated by sequential exposures to two different wavelengths. Additionally, this wavelength-dependent rise in NO is independent of the function of nitric oxide synthase, and highly dependent on the source of electrons feeding the electron transport chain of the light-exposed cells. In sum, these results provide a roadmap for interrogating the molecular mechanisms of PBM, and provide novel tools and methods for dissecting NO signaling networks.
Lexical Discovery with an Enriched Semantic Network. (1998)

The study of lexical semantics has produced a systematic analysis of binary relationships between content words that has greatly benefited lexical search tools and natural language processing algorithms. We first introduce a database system called FreeNet that facilitates the description and exploration of finite binary relations. We then describe the design and implementation of Lexical FreeNet, a semantic network that mixes WordNet-derived semantic relations with data-derived and phonetically-derived relations. We discuss how Lexical FreeNet has aided in lexical discovery, the pursuit of linguistic and factual knowledge by the computer-aided exploration of lexical relations. 1 Motivation This paper discusses Lexical FreeNet, a database system designed to enhance lexical discovery. By this we mean the pursuit of linguistic and factual knowledge with the computer-aided exploration of lexical relations. Lexical FreeNet is a semantic network that leverages WordNet and other knowledge a...
TAGLN2 is a candidate prognostic biomarker promoting tumorigenesis in human gliomas (2017)

Our findings indicate that TAGLN2 exerts a role in promoting the development of human glioma. The regulation and function of TAGLN2 therefore renders it as a candidate molecular target for the treatment of GBM.
Microwave-Assisted Synthesis of New Spiro[indoline-3,4′-quinoline] Derivatives via a One-Pot Multicomponent Reaction (2009)

Abstract A simple and efficient synthesis of spiro[indoline-3,4′-quinoline] derivatives by a one-pot reaction of isatin, malononitrile, and enaminone under microwave irradiation was investigated. This protocol has the advantages of short reaction time, high yields of products, broad substrate scope, and easy workup procedure.
The Impact of PSA Screening on Prostate Cancer Mortality and Overdiagnosis of Prostate Cancer in the United States (2012)

PSA testing was associated with modest reductions in prostate cancer mortality and large increases in the number of men overdiagnosed with and overtreated for prostate cancer. The results are similar to those obtained by the large European randomized prospective trial of PSA testing.
siRNAs in drug discovery: target validation and beyond. (2007)

'Omics' technologies, combined with knowledge management, have changed the way pharmaceutical companies approach drug discovery activities. The rapid generation of more reliable putative drug targets from gain- or loss-of-function genome scale screens means that there is a strong need to filter and prioritize targets that will be considered in the drug discovery process. Short interfering RNAs (siRNAs) can be used to validate genomic drug targets. The outlook for this approach is promising, provided that special attention is given to the use of optimal reagents and to careful development of animal models.
Synthesis and template properties of an ethyl phosphotriester modified decadeoxyribonucleotide (1982)

The phosphate groups of nucleic acids are often the targets of mutagenic and carcinogenic alkylating agents. In order to study the effects of alkyl phosphotriester modification on the physical and biochemical properties of DNA, two diastereomeric ethyl phosphotriester modified decadeoxyribonucleotides, d-CpCpApApGp(Et)ApTpTpGpG isomer I and isomer II, were prepared. A phosphotriester synthetic procedure was used to specifically place ethyl triester groups with either an R or S configuration in the central dimer region of the decamer. Terminal deoxynucleotidyl transferase was used to add oligodeoxyadenylate tails to the 3' end of the decamers. The resulting oligomers were tested as templates for Escherichia coli DNA polymerase I with d-(pT)8pCpC as a primer. The rates and extents of polymerization directed by the modified templates were 25% (isomer I) and 50% (isomer II) less than those of an unmodified control template. Thus the presence of an ethyl triester group inhibits polymerization, the effectiveness of which is determined by the orientation of the ethyl group relative to the rest of the template backbone. These results suggest ethyl phosphotriester lesions could inhibit replication rates of cellular DNA.
Cascading Style Sheets: The Definitive Guide, 2nd Edition (2004)

Simply put, Cascading Style Sheets (CSS) is a way to separate a document's structure from its presentation. The benefits of this can be quite profound: CSS allows a much richer document appearance than HTML; CSS saves time--you can create or change the appearance of an entire document in just one place; and its compact file size makes web pages load quickly. Eric Meyer, a member of the CSS&FP Working Group and an internationally known expert on HTML and CSS, tackles the subject with passion and delivers a comprehensive and thorough update to his groundbreaking book. All readers will benefit from both the depth and breadth of his experience and his clear and honest style. Cascading Style Sheets: The Definitive Guide, 2nd Edition is a thorough review of all aspects of CSS2.1 and a comprehensive guide to CSS implementation. The book includes new content on positioning, lists and generated content, table layout, user interface, paged media, and more. It explores in detail each individual CSS property and how it interacts with other properties, and shows how to avoid common mistakes in interpretation. If you're ready to take the next step with your HTML coding and incorporate CSS or are already a CSS code warrior, you'll find Cascading Style Sheets: The Definitive Guide, 2nd Edition is the book you've been craving.
Developement of an Interactive Power System Research Simulator (1984)

An interactive power system research simulator is described which has been developed specifically for interactive computation on time-sharing computer systems with high-speed cathode-ray tube (CRT)/printer interfaces.
Mémento des fondateurs de sociétés anonymes (Guide pratique des formalités à remplir pour constituer une société), par L. BATARDON. Un vol., 5¼ po. x 8½, broché, X et 138 pages —-DUNOD, 92, rue Bonaparte, Paris (6), 1960 (13.50 NF) (1961)

Mémento des fondateurs de sociétés anonymes (Guide pratique des formalités à remplir pour constituer une société), par L. BATARDON. Un vol., 5¼ po. x 8½, broché, X et 138 pages —-DUNOD, 92, rue Bonaparte, Paris (6e), 1960 (13.50 NF). Un article de la revue L'Actualité économique (Volume 36, numéro 4, janvier–mars 1961, p. 575-802) diffusée par la plateforme Érudit.
The Ranicon: A resistive anode image converter (1974)

A versatile photon and charged particle imaging system is described. The Ranicon employs a microchannel electron multiplier plate to convert each detected event into a charge signal. This charge pulse is proximity focused onto a large area resistive anode plate equipped with pickup electrodes on its edges. Each event is located electronically by the ratios of the charges collected at the edges or by the differences of the signals' rise times. One or two dimensional pictures are built up by storing events digitally (e.g., a core memory) or in analog form (e.g., a storage oscilloscope). Compact laboratory models have been constructed and tested. Operating characteristics, applications, limitations, and advantages of the Ranicon are discussed.
Interaction Under Pressure (2017)

Intuitive interaction has become a determining factor for the success of software. This paper contributes to this area of research by describing a novel method for evaluating intuitive interaction as increased mental workload in a dual-task paradigm. During a usability test, mental workload can be measured by analysing the timing of concurrent rhythmic foot tapping. Based on deviations from an individual baseline the method allows to point out the exact moments of increased workload, i.e. these moments where the interaction was likely non-intuitive. In formative usability tests, evaluators can use this information when conducting retrospective interviews to discuss the underlying intuitive-use problems and possible solutions. In contrast to other methods for evaluating intuitive interaction, which are often based on detailed user observations, the proposed method may yield a cost-effective and easily applicable alternative to conduct summative and formative evaluations of intuitive interaction.
Hétérogénéité des marchés et prix sans substance (2012)

L'ouvrage d'André Orléan - L'Empire de la valeur - présente deux caractéristiques. D'un côté, la publication de ce livre intervient dans une période où, selon l'auteur, " l'économie en tant que discipline traverse [...] une grave crise de légitimité " (EV, p. 9). La crise financière de 2008 aurait ainsi permis de mettre en lumière les erreurs...
SuperSAGE evidence for CD14++CD16+ monocytes as a third monocyte subset (2011)

Monocytes are a heterogeneous cell population with subset-specific functions and phenotypes. The differential expression of CD14 and CD16 distinguishes classical CD14(++)CD16(-), intermediate CD14(++)CD16(+), and nonclassical CD14(+)CD16(++) monocytes. Current knowledge on human monocyte heterogeneity is still incomplete: while it is increasingly acknowledged that CD14(++)CD16(+) monocytes are of outstanding significance in 2 global health issues, namely HIV-1 infection and atherosclerosis, CD14(++)CD16(+) monocytes remain the most poorly characterized subset so far. We therefore developed a method to purify the 3 monocyte subsets from human blood and analyzed their transcriptomes using SuperSAGE in combination with high-throughput sequencing. Analysis of 5 487 603 tags revealed unique identifiers of CD14(++)CD16(+) monocytes, delineating these cells from the 2 other monocyte subsets. Gene Ontology (GO) enrichment analysis suggests diverse immunologic functions, linking CD14(++)CD16(+) monocytes to Ag processing and presentation (eg, CD74, HLA-DR, IFI30, CTSB), to inflammation and monocyte activation (eg, TGFB1, AIF1, PTPN6), and to angiogenesis (eg, TIE2, CD105). In conclusion, we provide genetic evidence for a distinct role of CD14(++)CD16(+) monocytes in human immunity. After CD14(++)CD16(+) monocytes have earlier been discussed as a potential therapeutic target in inflammatory diseases, we are hopeful that our data will spur further research in the field of monocyte heterogeneity.
Mild brain hypothermia: potential for neuronal protection and resuscitation against ischemic damage (1997)

Although hypothermia as a means of neuronal protection and resuscitation after ischemic damage has a history of approximately four decades, extensive studies on the mechanisms, effects and methods of mild hypothermia at no less than 32°C have been started only in the last decade, both in basic and clinical fields. In experiments on rodents, postischemically introduced hypothermia, even as late as several hours after reperfusion, which was maintained for one day followed by a slow rewarming, definitely rescued hippocampal neurons against damage. Hypothermia appears to have a much greater potential for cerebral resuscitation than any chemical proposed so far for this purpose. The mode of action of hypothermia is apparently nonspecific and multifocal in widely progressing cascade reactions in ischemic cells, including (i) suppressing glutamate surge followed by (ii) intraneuronal calcium mobilization, (iii) postischemic sustained activation of glutamate receptors, (iv) dysfunction of blood-brain barrier, (v) proliferation of microglial cells, and (vi) production of superoxide unions and nitric oxide in microglial cells, and of activator protein-1 in ischemically vulnerable regions like hippocampal CA1. Recent clinical trials of mild hypothermia have revealed significantly beneficial outcomes along with an accumulation of knowhows on various techniques and treatments. Large scale randomized studies involving multiple institutions as well as exchanging ideas are needed for further development of hypothermia treatment. Biomedical Reviews 1997; 8: 23-36.
Polyester und Calciumphosphate als resorbierbare Biomaterialien (2003)

Die vorliegende Arbeit ist in 2 Abschnitte mit den Titeln Knochenersatzmaterialien und Alkali-2-halogencarboxylate\nunterteilt, die thematisch beide in den Bereich der Biomedizinischen Materialforschung gehören.\nKnochenersatzmaterialien. Hier wird die Entwicklung eines neuen, pH-neutralen Kompositmaterials aus Poly(α-\nhydroxycarbonsäuren) und carbonathaltigem Calciumphosphat für den Knochenersatz beschrieben. Anwendung findet das\nKompositmaterial in individuell geformten Schädelimplantaten, die durch eine eigens angepaßte Verfahrenskette\ngefertigt werden.\nAlkali-2-halogencarboxylate. Diese Substanzen sind die Ausgangsverbindungen einer neuen, festkörperchemischen\nSyntheseroute für Poly(α-hydroxycarbonsäuren). In dieser Arbeit wird speziell die Umsetzung von Alkali-2-\nhalogenpropionaten zu Polylactid untersucht. Die poröse Struktur dieser festkörperchemisch synthetisierten Polyester\nmacht sie besonders für den Einsatz in der kontrollierten Wirkstofffreisetzung interessant.
Direct Method for Rapid Prototyping of Near-Optimal Aircraft Trajectories (2000)

Adirectmethod fora real-timegenerationofnear-optimal spatialtrajectoriesofshort-term maneuversonboard a e ying vehiclewith predetermined thrust history isintroduced. Thepaperstarts with a survey about the founders of the direct methods of calculus of variations and their followers in e ight mechanics, both in Russia and in the United States. It then describes a new direct method based on three cues: high-order polynomials from the virtual arc as a reference function for aircraft’ s coordinates, a preset history of one of the controls (thrust), and a few optimization parameters. The trajectory optimization problem is transformed into a nonlinear programming problem and then solved numerically using an appropriate algorithm in accelerated scale of time. A series of examples is presented. Calculated near-optimal trajectory is compared with real e ight data, and with the solution obtainedbyPontryagin’ smaximumprinciple.Fastconvergenceofthenumericalalgorithm,whichhasbeenalready implemented and tested onboard a real aircraft, is illustrated. Nomenclature aik = polynomial coefe cients g = acceleration due to gravity J = cost function j = quantity pertaining to the jth time node m = aircraft mass N = number of nodes n = polynomial order ¯ n = relative revolutions of engine’ s rotor nx, nz = tangential and normal projections of load factor, respectively Sh = penalty function T, ¯ T = total thrust and relative thrust (fraction of maximum thrust), respectively t = time t ¤
OXIDATION OF AMMONIA IN FLAMES (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOXIDATION OF AMMONIA IN FLAMESC. P. Fenimore and G. W. JonesCite this: J. Phys. Chem. 1961, 65, 2, 298–303Publication Date (Print):February 1, 1961Publication History Published online1 May 2002Published inissue 1 February 1961https://pubs.acs.org/doi/10.1021/j100820a027https://doi.org/10.1021/j100820a027research-articleACS PublicationsRequest reuse permissionsArticle Views353Altmetric-Citations74LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
The P300: An Approach to Automated Inspection of Patterned Wafers (1989)

As IC groundrules shrink, manual optical inspection of multilevel patterned wafers becomes ineffective if not impossible, and efforts to develop automatic wafer inspection systems have expanded. This paper describes one successful approach, the P300 Automatic Wafer Inspection System[1], which uses a greylevel reference comparison of adjacent cells to locate defects on periodic pattern. The defects may be either pattern anomalies or particulates. Experiments demonstrate that the P300, scanning at a rate significantly faster than a human inspector, finds over ninety percent of half micron defects and over ninety-five percent of defects one micron or larger. By basing the inspection algorithm on a cell-to-cell comparison within a frame, as opposed to the conventional chip to chip or chip to CAD database reference, the system avoids detecting false alarms caused by acceptable variations in reflectivity, film thickness, critical dimensions and overlay registration over the surface of the wafer. A simple cell-to-cell comparison, however, would he prone to detecting false alarms due to electronic and digitization noise, aliasing, vibration, and illumination non-uniformity, as well as small scale acceptable process variation. By adding a statistical test to filter out noise and an edge detector to reduce sensitivity on edges, the false positive rate has been kept below a fraction of a percent of the frames inspected. The paper will discribe the system architecture and inspection algorithms and discuss specific inspection applications.
Circulating tumor cells (CTC) and KRAS mutant circulating free DNA (cfDNA) detection in peripheral blood as biomarkers in patients diagnosed with exocrine pancreatic cancer (2015)

Tumor specific cfDNA detection and CTC detection are promising markers for the management of patients with PDAC, although there is a need to validate these results in a larger patient cohort and optimize the detection of CTC in PDAC by applying the appropriate markers for their detection.
Overexpression of the PRAD1 Oncogene in a Patient with Multiple Myeloma and t(11;14)(q13;q32) (1995)

The t(11;14)(q13;q32) chromosomal translocation is associated with several B-cell lymphoproliferative disorders and is thought to result in upregulation of expression of PRAD1/cyclin D1 proto-oncogene. A patient with multiple myeloma of IgG kappa-type with t(11;14)(q13;q32) is now shown to overexpress PRAD1. The clinical stage of the disease was advanced (IIIA), with a myeloma cell count of 94.6% in the bone marrow. Chromosomal analysis of bone marrow cells showed t(11;14)(q13;q32) in five of 20 metaphases as well as other karyotypic features. Northern blot analysis of RNA prepared from myeloma cells revealed overexpression of PRAD1. Multiple myeloma with t(11;14)(q13;q32) has been associated with an aggressive clinical course. Although neither myeloma cells in the peripheral blood nor extramedullary lesions were apparent in the present patient, the myeloma was refractory to several chemotherapeutic regimens from the beginning. Detection of PRAD1 expression may offer an easier alternative to cytogenetic analysis in myeloma and is a potentially useful indicator of a poor prognosis.
High contrast ballistic imaging using femtosecond optical Kerr gate of tellurite glass (2013)

We investigated the ballistic imaging technique using femtosecond optical Kerr gate of a tellurite glass. High contrast images of an object hidden behind turbid media were obtained. Compared to the conventional femtosecond optical Kerr gate using fused quartz, the optical Kerr gate using tellurite glass has more capacity to acquire high quality images of the object hidden behind a high optical density turbid medium. The experimental results indicated that the tellurite glass is a good candidate as the optical Kerr material for the ballistic imaging technique due to its large optical nonlinearity.