gebhart/patrepeval huggingface dataset:
<i>In Situ</i> Hybridization Histochemistry: A Technique for the Study of Gene Expression in Single Cells (1983)

The patterns of growth hormone and proopiomelanocortin gene expression in the rat pituitary were used to detail the application of the in situ hybridization histochemistry technique in tissue sections. Parameters affecting the efficiency and resolution of hybridization have been optimized so that this technique can be used to identify sites of peptide synthesis and to study hormonal regulation of gene expression at the single cell level.
Effects of the proteasome inhibitor, bortezomib, on apoptosis in isolated lymphocytes obtained from patients with chronic lymphocytic leukemia. (2003)

Our data confirm that bortezomib, like other proteasome inhibitors, has proapoptotic activity in CLL cells.
Gas turbine APU reliability modeling and failure forecasting (2015)

This paper proposes a new reliability modeling approach for gas turbine APU (Auxiliary Power Unit). The main objective is to develop a practical procedure that can be used to predict the number of APU failures and prioritize failure risks within a fleet. The result can be used to better arrange repair activities and optimize resource allocation. The new method is statistical based and incorporates a variable repair effectiveness factor and virtual age concept. It is intended for aftermarket APUs with the assumption that an APU fleet has been in service long enough such that sufficient data has been accumulated. Many existing reliability models and forecasting approaches have certain limitations. This study develops a quantitative approach to resolving the reliability, repair and service challenges arising from complex repairable systems like gas turbine APUs. In additional to aerospace systems, it has the potential to be adapted to other applications.
A simulation study to compare the phase-shift angle radiofrequency ablation mode with bipolar and unipolar modes in creating linear lesions for atrial fibrillation ablation (2016)

Purpose In pulmonary veins (PVs) isolation (PVI), radiofrequency (RF) energy is often used to create a linear lesion for blocking the accessory conduction pathways around PVs. By using transient finite element analysis, this study compared the effectiveness of phase-shift mode (PsM) ablation with bipolar mode (BiM) and unipolar mode (UiM) in creating a continuous lesion and lesion depth in a 5-mm thick atrial wall. Materials and methods Computer models were developed to study the temperature distributions and lesion dimensions in atrial walls created through PsM, BiM, and UiM. Four phase-shift angles - 45°, 90°, 135°, and 180° - were considered in PsM ablation (hereafter, PsM-45°, PsM-90°, PsM-135°, and PsM-180°, respectively). Results At 60 s/30 V peak value of RF voltage, UiM and PsM-45° did not create an effective lesion, whereas BiM created a lesion of maximum depth and width approximately 1.01 and 1.62 mm, respectively. PsM-135° and PsM-180° not only created transmural lesions in 5-mm thick atrial walls but also created continuous lesions between electrodes spaced 4 mm apart; similarly, PsM-90° created a continuous lesion with a maximum depth and width of nearly 4.09 and 6.12 mm. Conclusions Compared with UiM and BiM, PsM-90°, PsM-135° and PsM-180° created continuous and larger lesions in a single ablation procedure and at 60 s/30 V peak value of RF voltage. Therefore, the proposed PsM ablation method is suitable for PVI and linear isolation at the left atrial roof for treating atrial fibrillation.
순수 휨하중을 받는 일축대칭 양단스텝보의 횡-비틀림 좌굴 강도 (2009)

본 연구에서는 유한요소해석를 통하여 순수휨을 받는 계단식 변단면 일축대칭 I형보의 탄성 횡-비틀림 죄굴 강도 산정법에 대해 설계식 개발이 수행되었다. 유한요소해석결과는 새로운 강도계산식 개발에 활용되었으며, 제안된 강도식은 해석결과와 잘 일치하는 결과를 나타내었다. 새로운 좌굴강도 제안식은 해석결과와 비교하여 -11%~2%의 오차범위를 나타내고 있으며, 모멘트 구배계수가 고려되지 않는다면 간편하게 안전측으로 설계에 적극 활용 가능하다. 또한, 다양한 하중 즉 집중하중, 등분포하중, 및 일련의 집중하중이 작용하는 일축대칭 변단면 부재의 좌굴강도 산정식 개발에 크게 기여하게 될 것이다.
HUME: A REFERENCE TO POPE (1960)

HUME: A REFERENCE TO POPE Get access CONSTANCE I. SMITH CONSTANCE I. SMITH Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume 7, Issue 3, 1 March 1960, Pages 115-b–115, https://doi.org/10.1093/nq/7-3-115b Published: 01 March 1960
LL-AF283 antibiotics, cyclic biphenyl peptides. (1991)

Pharmacokinetic, bacteriological and clinical studies on flomoxef (FMOX) in the perinatal period were carried out with the following summary of the results. Antibacterial effects of FMOX on the growth of methicillin-resistant Staphylococcus aureus (MRSA, MIC 400 micrograms/ml), methicillin-sensitive S. aureus (MSSA, MIC 0.78 microgram/ml), Escherichia coli (MIC 3.13 micrograms/ml and MIC 0.20 microgram/ml) in amniotic fluid were determined and it was found that the activity of FMOX was enhanced in the amniotic fluid. FMOX rapidly penetrated into tissues and sera of pregnant women upon intravenous injection and its maternal serum concentrations reached their peak levels shortly after administration. Placental penetration of FMOX to the fetus was good and, after single intravenous injection of 1 g, the concentrations of FMOX in the umbilical cord serum and amniotic fluid exceeded MICs against major causative organisms of perinatal infections. These results indicate that single intravenous injection of FMOX 1 g twice a day is effective for the treatment and prophylaxis of perinatal infections. Injection of FMOX for the treatment of 14 cases of puerperal infections showed excellent clinical effectiveness with 100% clinical effect and 81.8% bacteriological response. No side-effect was observed in any case. All of these results suggested clinical usefulness of FMOX in the perinatal period.
The pathogenic persona of community‐associated oral streptococci (2011)

The mitis group streptococci (MGS) are widespread in the oral cavity and are traditionally associated with oral health. However, these organisms have many attributes that contribute to the development of pathogenic oral communities. MGS adhere rapidly to saliva-coated tooth surfaces, thereby providing an attachment substratum for more overtly pathogenic organisms such as Porphyromonas gingivalis, and the two species assemble into heterotypic communities. Close physical association facilitates physiologic support, and pathogens such as Aggregatibacter actinomycetemcomitans display resource partitioning to favour carbon sources generated by streptococcal metabolism. MGS exchange information with community members through a number of interspecies signalling systems including AI-2 and contact dependent mechanisms. Signal transduction systems induced in P. gingivalis are based on protein dephosphorylation mediated by the tyrosine phosphatase Ltp1, and converge on a LuxR-family transcriptional regulator, CdhR. Phenotypic responses in P. gingivalis include regulation of hemin uptake systems and gingipain activity, processes that are intimately linked to the virulence of the organism. Furthermore, communities of S. gordonii with P. gingivalis or with A. actinomycetemcomitans are more pathogenic in animal models than the constituent species alone. We propose that MGS should be considered accessory pathogens, organisms whose pathogenic potential only becomes evident in the context of a heterotypic microbial community.
Crossing the Divide: Programs that Bridge Child & Adult Mental Health Services (2011)

A case of clinical porphyria cutanea tarda posed a diagnostic dilemma when screening tests for porphyrinuria gave negative results and two skin biopsy specimens failed to show the histologic picture of porphyria cutanea tarda, pseudoporphyria, or epidermolysis bullosa acquisita. The dilemma was resolved when the eruption cleared following elimination of naproxen from the patient's treatment. Subsequent naproxen challenge resulted in new bullae on the dorsum of the hands.
Effects of Thermal Treatments and Dendrimers Chemical Structures on the Properties of Highly Surface Cross-Linked Polyimide Films (2005)

We have conducted an extensive study to investigate the effects of thermal treatments and dendrimers' structures on the chemical and physical properties of the surface-modified polyimide films. The amidation and cross-linking reaction between G0 PAMAM dendrimers and polyimide were examined by XPS (X-ray photoelectron spectrometer) and FTIR-ATR (attenuated total reflection) measurements after thermal treatments under different temperatures. Moderate thermal treatment (120 °C) is proven to be able to induce the highly amidation reaction and to increase the degree of cross-linking on the polyimide surface. The gas separation performance of modified polyimide films is significantly improved due to the enhanced “molecular sieving” ability by dendrimer modification and the stronger interactions between the polyimide chains, such as covalent cross-linking bonding and hydrogen bonding. When the temperature of treatment reaches 250 °C, 1H NMR and GPC test implied that the cross-linking structure between polyimide chains is broken and that the degradation of polyimide backbone chains also occurs. Gas permeation tests also indicated that high-temperature treatment of dendrimer-modified polyimide films is not beneficial to separation. In addition, the performance comparison between different dendrimers, PAMAM- and DAB-modified films, is carried out. The chemical structural differences in PAMAM and DAB dendrimers have also been verified as one of the important factors in determining the properties of modified polyimide films. At room temperature, PAMAM dendrimers show stronger cross-linking ability.
Spatiotemporal Chromaticity Discrimination* (1969)

The threshold visibility of uniformly moving colored gratings was investigated. The gratings were equiluminous sine-wave patterns, generated on a color-television display. The traveling waves were detected by the subject over a range of three log units of background illuminance, including various spatial- and temporal-frequency combinations. The experiments indicate that no resonance phenomena occur in the spatiotemporal color-discrimination system of the eye. This system probably functions as a low-pass filter. The color coding takes place in much narrower frequency bands than the brightness coding. A regular motion of the pattern never enhances the visibility of the color gratings. The temporal characteristics of the chromatic-discrimination system show very much resemblance to its spatial qualities. Our experiments show that the threshold chromatic contrast is proportional to the square root of the illuminance. This fundamental relationship can easily be understood from the statistical properties of the photons, absorbed in the differential receptor systems.
Strategic Threat Probabilities with Hierarchical Spatiotemporal Predictions (2015)

After many years involved in unconventional warfare and an increase in fiscal constraints, quantitative support for decision making is more important today than in the past. Decisions focused on risk and strategic objectives are critical for changing how we approach the global terrorism threat. This article examines a framework for threat likelihood prediction models based on the underlying patterns in the multivariate, multilevel, spatial, and temporal correlations from previous incidents. The models in this research focus on logistic and discrete choice formulations and use a time-correlated cross-validation evaluation method to measure predictive performance. The information gained from these models serves to inform where national instruments of power could aid in deterring the global terrorism threat.
<i>Streptococcus suis</i>Bacterin and Subunit Vaccine Immunogenicities and Protective Efficacies against Serotypes 2 and 9 (2008)

Streptococcus suis causes numerous diseases in pigs, most importantly, meningitis, arthritis, septicemia, and bronchopneumonia. One of the major problems in modern swine production is the lack of a vaccine protecting against more than one S. suis serotype. The objective of this study was to determine the protective efficacy of a serotype 2 murein-associated protein (MAP) fraction subunit vaccine in comparison to that of a bacterin against experimental challenge with serotype 2 (containing muramidase-released protein [MRP], extracellular factor, and suilysin [SLY]) and serotype 9 (containing MRP variant MRP* and SLY) strains. MAP was shown to include different surface-associated proteins, such as the MRP and surface antigen one (SAO) expressed by both pathotypes used for challenge. The results of this study demonstrated that the serotype 2 bacterin induced protective immunity against homologous challenge. In contrast, the protective efficacy of the MAP subunit vaccine was low, though MAP immunization resulted in high serum immunoglobulin G2 titers against MRP and SAO. Importantly, immunization with bacterin but not with MAP induced opsonizing antibody titers against the serotype 2 strain, and these antibody titers were found to correlate with protection. However, after absorption with a nonencapsulated isogenic mutant, the sera from bacterin-immunized piglets failed to facilitate neutrophil killing, indicating that antibodies directed against capsule may not have been essential for opsonophagocytosis. Furthermore, induction of opsonizing antibodies against serotype 9 was not detectable in the group receiving bacterin or in the group receiving the MAP vaccine. In agreement, protection against the heterologous serotype 9 strain was low in both groups. Thus, identification of an antigen protecting against these two important S. suis pathotypes remains an important goal of future studies.
New Dithiolopyrrolone Antibiotics from Saccharothrix sp. SA 233. Part 1. Taxonomy, Fermentation, Isolation and Biological Activities. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
The Enterprise System Experience— From Adoption to Success (2000)

173 For some 20 years after John Dearden wrote these words, history proved him right. Today, however, there is a booming market for software packages claiming to provide a total, integrated solution to companies’ information-processing needs. Even companies that choose not to adopt such packages are pursuing aggressive strategies of systems integration by redeveloping custom software and adopting technologies such as data warehousing. Integrated enterprise systems deserve serious research attention because of their great potential for financial, technical, managerial, human, and strategic benefits, costs, and risks. This chapter provides a theoretical framework for analyzing, both retrospectively and prospectively, the business value of enterprise systems. We first describe the historical context in which enterprise systems emerged. Next we identify the key characteristics of enterprise systems, discuss the reasons companies do and do not adopt them, and summarize arguments about why enterprise systems are an important topic for research. We then analyze enterprise systems in terms of the concept of success. We argue that the many facets of success create difficulties for
Current Status of Optical Imaging for Evaluating Lymph Nodes and Lymphatic System (2015)

Optical imaging techniques use visual and near infrared rays. Despite their considerably poor penetration depth, they are widely used due to their safe and intuitive properties and potential for intraoperative usage. Optical imaging techniques have been actively investigated for clinical imaging of lymph nodes and lymphatic system. This article summarizes a variety of optical tracers and techniques used for lymph node and lymphatic imaging, and reviews their clinical applications. Emerging new optical imaging techniques and their potential are also described.
Tetrathiahexacene as Building Block for Solution-Processable Semiconducting Polymers: Exploring the Monomer Size Limit (2010)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTTetrathiahexacene as Building Block for Solution-Processable Semiconducting Polymers: Exploring the Monomer Size LimitRalph Rieger, Dirk Beckmann, Wojciech Pisula, Marcel Kastler, and Klaus Müllen*View Author Information Max Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany*Corresponding author. E-mail: [email protected]Cite this: Macromolecules 2010, 43, 15, 6264–6267Publication Date (Web):July 14, 2010Publication History Received27 May 2010Revised25 June 2010Published online14 July 2010Published inissue 10 August 2010https://doi.org/10.1021/ma101183bCopyright © 2010 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views2074Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (1 MB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Monomers,Organic polymers,Polymer solutions,Polymers,Transistors Get e-Alerts
Networked reminiscence therapy for individuals with dementia by using photo and video sharing (2006)

Reminiscence therapy, which is effective for increasing the selfesteem of and for reducing behavioral disturbances in individuals with dementia, is usually conducted in a group led by experienced staff. However, due to the shortage of care attendants, only a limited number of patients at home can receive the benefits of this therapy. To provide this therapy for patients anytime or anywhere, we have developed a networked reminiscence therapy system that combines IP videophones with a photo- and video-sharing mechanism based on Web technology. First, we prepared the experimental setup in a hospital and examined whether dementia patients could communicate with therapists by videophone. Then we conducted a field trial of networked reminiscence therapy with a more realistic situation where remote volunteers communicated with dementia sufferers in the care home by IP videophones connected by broadband network. In this paper, we describe our developed system. Then, we present experimental results showing that dementia sufferers could communicate with therapists by videophone and that networked reminiscence sessions were generally as successful for individuals with dementia as face-to-face reminiscence sessions.
Passivation of Grain Boundaries by Phenethylammonium in Formamidinium-Methylammonium Lead Halide Perovskite Solar Cells (2018)

In this work, we report the benefits of incorporating phenethylammonium cation (PEA+) into (HC(NH2)2PbI3)0.85(CH3NH3PbBr3)0.15 perovskite for the first time. After adding small amounts of PEA cation (<10%), the perovskite film morphology is changed but, most importantly, grain boundaries are passivated. This is supported by Kelvin Probe Force Microscopy (KPFM). The passivation results in the increase in photoluminescence intensity and carrier lifetimes of test structures and open-circuit voltages (VOC) of the devices as long as the addition of PEA+ is ≤4.5%. The presence of higher-band-gap quasi-2D PEA incorporated perovskite is responsible for the grain boundary passivation, and the quasi-2D perovskites are also found to be concentrated near the TiO2 layer, revealed by PL spectroscopy. Results of moisture exposure tests show that PEA+ incorporation is effective in slowing down the degradation of unencapsulated devices compared to the control devices without PEA+. These findings provide insights into the operation of perovskite solar cells when large cations are incorporated.
The Changing Epidemiology of Mechanical Ventilation: A Population-Based Study (2006)

The number of critical care beds in the United States has been increasing considerably, but it is unclear how these additional beds have been used. Mechanical ventilation for acute respiratory failure almost always demands ICU care and is likely to be a reliable indicator of critical care resource requirements on a population level. The objective of this study was to measure changes in the yearly incidence of mechanical ventilation in a statewide population. The North Carolina Hospital Discharge Database contains data on all discharges from nonfederal, nonpsychiatric hospitals in North Carolina. Authors extracted data on adult patients with International Classification of Diseases, 9th Revision, Clinical Modification procedure codes for mechanical ventilation from 1996 to 2002. The incidence of mechanical ventilation for adults grew from 284/100,000 population in 1996 to 314/100,000 in 2002, an increase of 11% (P < .05). While patients aged >64 had the highest age-specific incidence of mechanical ventilation each year, the greatest increase in incidence occurred in younger age groups (19% increase for age 18-64 vs 4% increase for age >64). The mean Charlson score increased from 1.76 +/- 1.73 to 1.89 +/- 1.86 (P < .001). Renal disease became more prevalent among patients requiring mechanical ventilation (17% of patients in 1996 vs 24% in 2002). Hospital charges adjusted for the medical consumer price index increased by 12%. The proportion of patients discharged to home declined from 45.4% to 34.4%, and discharges to nursing homes grew from 7.3% to 10.7%. The incidence of mechanical ventilation is increasing, and the increase is associated with a higher burden of comorbidities and fewer discharges to home.
Decision tree state tying based on segmental clustering for acoustic modeling (2002)

A fast segmental clustering approach to decision tree tying based acoustic modeling is proposed for large vocabulary speech recognition. It is based on a two level clustering scheme for robust decision tree state clustering. This approach extends the conventional segmental K-means approach to phonetic decision tree state tying based acoustic modeling. It achieves high recognition performances while reducing the model training time from days to hours comparing to the approaches based on Baum-Welch training. Experimental results on standard Resource Management and Wall Street Journal tasks are presented which demonstrate the robustness and efficacy of this approach.
Robust speaker verification with optimal pitch bases expansions (2004)

We are presenting a new method to improve the robustness of speaker verification algorithms. It is based on an innovative approach that departs radically from commonly used mechanisms for speech recognition and speaker verification. In addition to speech features derived from spectral analysis, we are using speech features derived from orthogonal expansions of pitch period segments. The expansions are designed to optimally match the characteristics of a given speaker. Our research demonstrates that the presented strategy delivers a performance that is superior to traditional methods in the context of text-dependent speaker verification with cooperative speakers in a low noise environment. In experiments we were able to reduce the probability of impostor access by more than 50%. The overall complexity of the proposed algorithm is comparable to the complexity of algorithms in current commercial products.