gebhart/patrepeval huggingface dataset:
Variations in concentrations of bacterial metabolites, enzyme activities, moisture, pH and bacterial composition between and within individuals in faeces of seven healthy adults (1994)

Variations between and within individuals, and correlations between concentrations of bacterial metabolites, including putrefactive products, ammonia and short chain fatty acids (SCFAs), enzyme activities, moisture and pH, as well as bacterial composition, were studied in faecal samples from seven healthy adults over a period of 7 months. Large variations, both between and within individuals, were observed in concentrations of putrefactive products. Although values for ammonia, SCFAs, enzyme activities, moisture and pH were generally variable, significant person-to-person differences were observed. While ranges of log viable counts of the predominant bacteria such as eubacteria, bifidobacteria and bacteroides in each subject remained between 0.2 and 1.3, those of enterobacteria, streptococci (including enterococci) and lecithinase-negative clostridia varied between 0.4 and 3.0. Levels of bifidobacteria, enterobacteria, streptococci and total aerobic bacteria showed inter-individual variations. Correlations were found among certain of the parameters: moisture correlated negatively with p-cresol (r = -0.707), pH (r = -0.671) and beta-glucosidase activity (GS) (r = -0.608), and positively with acetic acid (r = 0.621), while negative correlations were observed in pH with acetic and butyric acids (r = -0.690 and -0.623, respectively). No significant correlations were found between bacterial compositions, and other faecal factors such as pH, moisture, metabolic enzyme activities and concentrations of putrefactive products.
Fingerprint classification using an AM-FM model (2001)

Research on fingerprint classification has primarily focused on finding improved classifiers, image and feature enhancement, and less on the development of novel fingerprint representations. Using an AM-FM representation for each fingerprint, we obtain significant gains in classification performance as compared to the commonly used National Institute of Standards system, for the same classifier.
Detection and isolation of plant failures in dynamic systems. (1991)

This dissertation extends current Failure Detection and Isolation (FDI) theory and application for linear systems to include the detection and isolation of changes in the state transition matrix (or plant failures). Solutions to the problem of detecting such changes and isolating these changes from additive actuator failures are presented. Both deterministic systems and stochastic systems are considered. A new failure detection and isolation algorithm is presented for linear time-invariant deterministic systems. In particular, the technique exploits the system inputs to distinguish between a change in the state transition matrix and actuator calibration errors. Previous methods that attempted to isolate changes in the state transition matrix did not use the input in any way and required explicit knowledge of the changed parameter values (e.g., the multiple model method). The designed input method on the other hand requires only the knowledge of the null spaces of the changed parameter matrices, not of the explicit values of the changed parameters. This feature allows the FDI algorithm based on designed inputs to isolate changes in the state transition matrix with unknown magnitudes, a distinct advantage over other methods in terms of computationally efficient algorithms. Detailed design procedures are accompanied by five examples that illustrate the various features of the input design method. For linear time-varying stochastic systems, a suboptimal generalized likelihood ratio algorithm is designed that isolates certain additive actuator failures from changes in the state transition matrix. The problem is formulated as a binary decision problem between an actuator failure with partially known changed parameters and a change in the state transition matrix with completely known changed parameters. The resulting algorithm is simulated and verified using internal combustion engine models for both known and unknown event onset times. A lower bound on the average probability of error is presented and the performance of the algorithm is compared to the bound.
Repositioning drugs for traumatic brain injury - N-acetyl cysteine and Phenserine (2017)

Traumatic brain injury (TBI) is one of the most common causes of morbidity and mortality of both young adults of less than 45 years of age and the elderly, and contributes to about 30% of all injury deaths in the United States of America. Whereas there has been a significant improvement in our understanding of the mechanism that underpin the primary and secondary stages of damage associated with a TBI incident, to date however, this knowledge has not translated into the development of effective new pharmacological TBI treatment strategies. Prior experimental and clinical studies of drugs working via a single mechanism only may have failed to address the full range of pathologies that lead to the neuronal loss and cognitive impairment evident in TBI and other disorders. The present review focuses on two drugs with the potential to benefit multiple pathways considered important in TBI. Notably, both agents have already been developed into human studies for other conditions, and thus have the potential to be rapidly repositioned as TBI therapies. The first is N-acetyl cysteine (NAC) that is currently used in over the counter medications for its anti-inflammatory properties. The second is (-)-phenserine ((-)-Phen) that was originally developed as an experimental Alzheimer's disease (AD) drug. We briefly review background information about TBI and subsequently review literature suggesting that NAC and (-)-Phen may be useful therapeutic approaches for TBI, for which there are no currently approved drugs.
Realistic Evaluation of Deep Semi-Supervised Learning Algorithms (2018)

Semi-supervised learning (SSL) provides a powerful framework for leveraging unlabeled data when labels are limited or expensive to obtain. SSL algorithms based on deep neural networks have recently proven successful on standard benchmark tasks. However, we argue that these benchmarks fail to address many issues that these algorithms would face in real-world applications. After creating a unified reimplementation of various widely-used SSL techniques, we test them in a suite of experiments designed to address these issues. We find that the performance of simple baselines which do not use unlabeled data is often underreported, that SSL methods differ in sensitivity to the amount of labeled and unlabeled data, and that performance can degrade substantially when the unlabeled dataset contains out-of-class examples. To help guide SSL research towards real-world applicability, we make our unified reimplemention and evaluation platform publicly available.
Effect of ischaemia on sensory potentials of normal subjects of different ages (1973)

In 73 normal subjects, from 10 to 82 years of age, maximum orthodromic sensory nerve conduction velocity was measured in the median nerve before and during a 30 minute period of vascular occlusion. During ischaemia progressive slowing in conduction velocity, decrease in amplitude, and increase in duration of the sensory action potential evoked at wrist and elbow by supramaximal stimulation of digit III were observed. However, a statistically significant difference (P<0·05 to P<0·01) between subjects was noted by grouping them by age: the older the subject, the longer the persistence of sensory response and the less marked the slowing in conduction velocity. The mechanism of the phenomenon has been discussed in relation to a similar longer resistance to ischaemia found in peripheral nerves of diabetic and uraemic patients.
Characterization of a Novel Lipid A Containingd-Galacturonic Acid That Replaces Phosphate Residues (2000)

According to the 16 S rRNA phylogenetic tree, the hyperthermophilic bacterium Aquifex pyrophilus represents the deepest and shortest branching species of the kingdom Bacteria. We show for the first time that an organism, which is phylogenetically ancient on the basis of its 16 S rRNA and that exists at extreme conditions, may contain lipopolysaccharide (LPS). The LPS was extracted from dried bacteria using a modified phenol/water method. SDS-polyacrylamide gel electrophoresis and silver stain displayed a ladder-like pattern, which is typical for smooth-form LPS (possessing an O-specific polysaccharide). The molecular masses of the LPS populations were determined by matrix-assisted laser-desorption ionization mass spectrometry. Lipid A was precipitated after mild acid hydrolysis of LPS. Its complete structure was determined by chemical analyses, combined gas-liquid chromatography-mass spectrometry, matrix-assisted laser-desorption ionization mass spectrometry, and one- and two-dimensional NMR spectroscopy. The lipid A consists of a beta-(1-->6)-linked 2,3-diamino-2,3-dideoxy-D-glucopyranose (DAG) disaccharide carrying two residues each of (R)-3-hydroxytetradecanoic acid and (R)-3-hydroxyhexadecanoic acid in amide linkage and one residue of octadecanoic acid in ester linkage. Each DAG moiety carries one residue of each 3-hydroxytetradecanoic and 3-hydroxyhexadecanoic acid. In the nonreducing DAG, the octadecanoic acid is attached to the 3-hydroxy group of 3-hydroxytetradecanoic acid. Each DAG is substituted by one D-galacturonic acid residue, which is linked to O-1 of the reducing and to O-4 of the nonreducing end. This structure represents a novel type of lipid A.
A hardware architecture for implementing protection rings (1972)

Protection of computations and information is an important aspect of a computer utility. In a system which uses segmentation as a memory addressing scheme, protection can be achieved in part by associating concentric rings of decreasing access privilege with a computation. This paper describes hardware processor mechanisms for implementing these rings of protection. The mechanisms allow cross-ring calls and subsequent returns to occur without trapping to the supervisor. Automatic hardware validation of references across ring boundaries is also performed. Thus, a call by a user procedure to a protected subsystem (including the the supervisor) is identical to a call to a companion user procedure. The mechanisms of passing and referencing arguments are the same in both cases as well.
Coherent control of enrichment and conversion of molecular spin isomers (2001)

A theoretical model of nuclear spin conversion in molecules controlled by an external electromagnetic radiation resonant to a rotational transition is developed. It is shown that one can produce an enrichment of spin isomers and influence their conversion rates in two ways, through coherences and through level population changes induced by radiation. The effect on conversion ranges from significant speed-up to almost complete inhibition of the process by proper choice of frequency and intensity of the external field.
Improving the data cache performance of multiprocessor operating systems (2002)

Bus-based shared-memory multiprocessors with coherent caches have recently become very popular. To achieve high performance, these systems rely on increasingly sophisticated cache hierarchies. However, while these machines often run loads with substantial operating system activity, performance measurements have consistently indicated that the operating system uses the data cache hierarchy poorly. In this paper, we address the issue of how to eliminate most of the data cache misses in a multiprocessor operating system while still using off-the-shelf processors. We use a performance monitor to examine traces of a 4-processor machine running four system-intensive loads under UNIX. Based on our observations, we propose hardware and software support that targets block operations, coherence activity, and cache conflicts. For block operations, simple cache bypassing or prefetching schemes are undesirable. Instead, it is best to use a DMA-like scheme that pipelines the data transfer in the bus without involving the processor. Coherence misses are handled with data, privatization and relocation, and the use of updates for a small core of shared variables. Finally, the remaining miss hot spots are handled with data prefetching. Overall, our simulations show that all these optimizations combined eliminate or hide 75% of the operating system data misses in 32-Kbyte primary caches. Furthermore, they speed up the operating system by 19%.
Purification and characterization of a malic enzyme from the ruminal bacterium Streptococcus bovis ATCC 15352 and cloning and sequencing of its gene (1996)

Malic enzyme (EC 1.1.1.39), which catalyzes L-malate oxidative decarboxylation and pyruvate reductive carboxylation, was purified to homogeneity from Streptococcus bovis ATCC 15352, and properties of this enzyme were determined. The 2.9-kb fragment containing the malic enzyme gene was cloned, and the sequence was determined and analyzed. The enzymatic properties of the S. bovis malic enzyme were almost identical to those of other malic enzymes previously reported. However, we found that the S. bovis malic enzyme catalyzed unknown enzymatic reactions, including reduction of 2-oxoisovalerate, reduction of 2-oxoisocaproate, oxidation of D-2-hydroxyisovalerate, and oxidation of D-2-hydroxyisocaproate. The requirement for cations and the optimum pH of these unique activities were different from the requirement for cations and the optimum pH of the L-malate oxidative decarboxylating activity. A sequence analysis of the cloned fragment revealed the presence of two open reading frames that were 1,299 and 1,170 nucleotides long. The 389-amino-acid polypeptide deduced from the 1,170-nucleotide open reading frame was identified as the malic enzyme; this enzyme exhibited high levels of similarity to malic enzymes of Bacillus stearothermophilus and Haemophilus influenzae and was also similar to other malic enzymes and the malolactic enzyme of Lactococcus lactis.
<title>Microtopography investigations of optical surfaces and thin films by light scattering, optical profilometry, and atomic-force microscopy</title> (1993)

The roughness of a number of uncoated glass substrates with different surface quality as well as surfaces of fluoride films is investigated by various characterization techniques. The influence of bandwidth limitation and the dependence on the examined sample area become obvious. The results obtained from the different measuring methods are shown to complement each other appropriately.
Highly efficient Nd:YAG lasers for free-space optical communications (1985)

A highly efficient Nd:YAG laser end-pumped by semiconductor lasers as a possible free-space optical communications source is discussed. Because this concept affords high pumping densities, a long absorption length, and excellent mode-matching characteristics, it is estimated that electrical-to-optical efficiencies greater than 5% could be achieved. Several engineering aspects such as resonator size and configuration, pump collecting optics, and thermal effects are also discussed. Finally, possible methods for combining laser-diode pumps to achieve higher output powers are illustrated.
Lightweight DC-DC Converter with Partial Power Processing and MPPT for a Solar Powered Aircraft (2015)

A lightweight dc-dc partial power processing converter is demonstrated for solar aerospace applications. A system-level model is conceived to determine conformity to payload and target distance objectives, with the Solarship aircraft used as an application example. The concept of partial power processing is utilized to realize a high efficiency lightweight converter that performs Max Peak Power Tracking (MPPT) to transfer power from the aircraft solar array to the high-voltage battery bus. The isolated Cuk is determined to be a suitable converter topology for the application. A small-signal model is derived for control design. The operation of a 400V, 2.7 kW prototype is verified at high frequency (200 kHz), high efficiency (> 98%), small mass (0.604 kg), and uses no electrolytic capacitors. MPPT operation is verified on a 376 V commercial solar installation at The University of Toronto. The prototype serves as an enabling technology for solar aerospace applications.
Photoionization dynamics and abundance patterns in laser vaporized tin and lead clusters (1987)

Tin and lead clusters are produced by laser vaporization in a pulsed nozzle source and studied with laser photoionization mass spectroscopy. ‘‘Magic numbers’’ are observed in both cluster size distributions under a variety of laser wavelength and power conditions which can be understood in terms of ionization thresholds, relative ionization cross sections, and multiphoton-induced fragmentation. After investigation of the photoionization dynamics, relative abundances of different sized clusters are estimated. Abundance patterns of tin and lead clusters are compared to those reported previously for other group IV elements (C, Si, Ge) to investigate the role of periodicity in cluster growth and bonding properties. Especially abundant 10-atom cluster species are observed for both tin and lead, as has been observed previously for both silicon and germanium. Other features not observed for silicon and germanium, such as abundance patterns characteristic of atom closepacking geometries, are observed to a limited degree for tin clusters and are more prominent in lead clusters.
<i>TGFBR1</i> Haplotypes and Risk of Non–Small-Cell Lung Cancer (2009)

Transforming growth factor beta (TGF-beta) receptors are centrally involved in TGF-beta-mediated cell growth and differentiation and are frequently inactivated in non-small-cell lung cancer (NSCLC). Constitutively decreased type I TGF-beta receptor (TGFBR1) expression is emerging as a novel tumor-predisposing phenotype. The association of TGFBR1 haplotypes with risk for NSCLC has not yet been studied. We tested the hypothesis that single-nucleotide polymorphisms (SNP) and/or TGFBR1 haplotypes are associated with risk of NSCLC. We genotyped six TGFBR1 haplotype-tagging SNPs (htSNP) by PCR-RFLP assays and one htSNP by PCR-single-strand conformation polymorphism assay in two case-control studies. Case-control study 1 included 102 NSCLC patients and 104 healthy controls from Suzhou. Case-control study 2 included 131 patients with NSCLC and 133 healthy controls from Wuxi. Individuals included in both case-control studies were Han Chinese. Haplotypes were reconstructed according to the genotyping data and linkage disequilibrium status of these seven htSNPs. None of the htSNP was associated with NSCLC risk in either study. However, a four-marker CTGC haplotype was significantly more common among controls than among cases in both studies (P = 0.014 and P = 0.010, respectively), indicating that this haplotype is associated with decreased NSCLC risk {adjusted odds ratio [OR], 0.09 [95% confidence interval (95% CI), 0.01-0.61] and 0.11 [95% CI, 0.02-0.59], respectively}. Combined analysis of both studies shows a strong association of this four-marker haplotype with decreased NSCLC risk (adjusted OR, 0.11; 95% CI, 0.03-0.39). This is the first evidence of an association between a TGFBR1 haplotype and risk for NSCLC.
A direct fluorescence study of the transient steps induced by calcium binding to sarcoplasmic reticulum ATPase. (1980)

The sarcoplasmic reticulum intrinsic fluorescence level was closely correlated with the ATPase functional state, from pH 5.5 to 8.5. The fluorescence signal was used in stopped flow measurements for direct study of transient pump kinetics after calcium binding or removal. The signal change time course, which depends solely on the free calcium concentration in the observation chamber, was analyzed as a single exponential. Rate constants (kobs) were relatively slow (5 to 20 s-1), indicating multistep interaction between calcium and the transport protein. At pH 7 and 20 degrees C, and in the presence of 100 mM potassium and 1 to 20 mM MgCl2, kobs first decreased, and then increased as the calcium concentration rose. Similar experiments were performed at pH 6. Data were analyzed according to a scheme in which sarcoplasmic reticulum . calcium complex formation is controlled by a slow isomerization step occurring either before or after the rapid calcium binding to the high affinity site. The results are discussed with reference to published rapid quenching experiments. Under our conditions, i.e. in the absence of a calcium gradient across the membrane, the calcium pump cycle step in which reorientation of the calcium binding sites occurs cannot be identified with the isomerization step mentioned above.
Angiotensin-Converting Enzyme Inhibition Suppresses Plasminogen Activator Inhibitor-1 Expression in the Neointima of Balloon-Injured Rat Aorta (1996)

This report demonstrates that balloon injury results in both a rapid ACE inhibitor-independent induction of aortic PAI-1 expression and a later increase in PAI-1 in the neointima that is significantly suppressed by captopril. This provides the first evidence that the renin-angiotensin system regulates neointimal PAI-1 expression and that ACE inhibitors can reduce PAI-1 in the vessel wall in vivo.
Adhesive Bonding of InP∕InGaAsP Dies to Processed Silicon-On-Insulator Wafers using DVS-bis-Benzocyclobutene (2006)

The process of bonding InP/InGaAsP dies to a processed silicon-on-insulator wafer using sub-300 nm layers of DVS-bisbenzocyclobutene BCB was developed. The planarization properties of these DVS-bis-BCB layers were measured and an optimal prebonding die preparation and polymer precure are presented. Bonding quality and bonding strength are assessed, showing high-quality bonding with sufficient bonding strength to survive postbonding processing.
Selective Dopamine Transport Using a Crown Boronic Acid (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSelective Dopamine Transport Using a Crown Boronic AcidMarie-France Paugam, Linbee S. Valencia, Bill Boggess, and Bradley D. SmithCite this: J. Am. Chem. Soc. 1994, 116, 24, 11203–11204Publication Date (Print):November 1, 1994Publication History Published online1 May 2002Published inissue 1 November 1994https://doi.org/10.1021/ja00103a064RIGHTS & PERMISSIONSArticle Views598Altmetric-Citations51LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (328 KB) Get e-AlertsSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts