gebhart/patrepeval huggingface dataset:
Application of isotopically enriched germanium tetrafluoride for contaminant reduction and ion source lifetime benefits (2002)

Wafer contamination is a critical factor in today's semiconductor fabs. This paper discusses Philips Semiconductor's efforts to reduce iron contamination, as observed on Axcelis GSD's implanting boron and germanium at the New York based fab. While implementing the process to reduce the iron contamination, it was discovered that the ion source lifetime had been significantly increased by the use of isotopically enriched germanium tetrafluoride. Information and data will be presented to confirm the significant increased lifetime and the reduction of iron contamination.
Remote collaboration in AR and VR using virtual replicas (2017)

In many complex tasks, a remote subject-matter expert may need to assist a local user, to guide their actions on objects in the local user's environment. However, effective spatial referencing and action demonstration in a remote physical environment can be challenging. We demonstrate an approach that uses Virtual Reality (VR) or Augmented Reality (AR) for the remote expert, and AR for the local user, each wearing a stereo head-worn display (HWD). Our approach allows the remote expert to create and manipulate virtual replicas of physical objects in the local environment to refer to parts of those physical objects and to indicate actions on them. This can be especially useful for parts that are occluded or difficult to access. The remote expert can demonstrate actions in 3D by manipulating virtual replicas, supported by constraints and annotations, and point in 3D to portions of virtual replicas to annotate them.
패션 T-commerce 구매의도의 영향요인에 관한 연구: 확장 기술수용모형(TAM)을 중심으로 (2011)

본 연구는 기술수용모형(TAM)을 토대로 패션제품 T-Commerce에 영향을 미치는 요인을 규명하고자 하였다. 이를 위해 기존의 TAM 모형에서 중요하게 사용되었던 선행변인 (자기효능감, 기술혁신성, 즐거움) 이외에도 패션제품의 특성상 유행관여라는 새로운 변수를 TAM 모형에 하여 확장된 TAM 모형이 패션제품 T-Commerce의 구매의도에 어떤 영향을 미치는지 검증하고자 하였다. 제시한 연구모형은 구조방정식모델을 통하여 분석 되었다. 분석결과 자기효능감은 지각된 용이성에 영향을 미치는 것으로 나타났으며, 기술혁신성은 즐거움에 영향을 미치는 것으로 나타났다. 유행관여는 모든 변수에 영향을 미치는 것으로 나타났으며, 지각된 사용용이성은 유용성과 즐거움에 영향을 미치고, 지각된 유용성, 사용용이성, 즐거움 모두 구매의도에 영향을 미치는 것으로 나타났다. 수정 된 연구모형에서도 유행관여가 구매의도에 직접 영향을 미치는 것으로 나타나 유행관여가 T-commerce에 매우 주요한 변인임을 밝혀주었다. 본 연구결과를 토대로 패션 T-Commerce 구매의도의 예측변인들을 밝히고, 구매의도를 높일 수 있는 활용방안을 모색함으로써 향후 패션 T-Commerce 리테일러들에게 T-Commerce기획 및 마케팅전략 에 도움이 되는 실무적인 시사점을 제시하고자 한다.
Hadoop Operations (2012)

If youve been asked to maintain large and complex Hadoop clusters, this book is a must. Demand for operations-specific material has skyrocketed now that Hadoop is becoming the de facto standard for truly large-scale data processing in the data center. Eric Sammer, Principal Solution Architect at Cloudera, shows you the particulars of running Hadoop in production, from planning, installing, and configuring the system to providing ongoing maintenance.Rather than run through all possible scenarios, this pragmatic operations guide calls out what works, as demonstrated in critical deployments.Get a high-level overview of HDFS and MapReduce: why they exist and how they work Plan a Hadoop deployment, from hardware and OS selection to network requirements Learn setup and configuration details with a list of critical properties Manage resources by sharing a cluster across multiple groups Get a runbook of the most common cluster maintenance tasks Monitor Hadoop clustersand learn troubleshooting with the help of real-world war stories Use basic tools and techniques to handle backup and catastrophic failure
HLA-DR2a is the dominant restriction molecule for the cytotoxic T cell response to myelin basic protein in DR2Dw2 individuals. (1990)

The HLA-DR2 restriction of the T cell response to myelin basic protein (MBP) was studied using murine L cells transfected with DRalpha and either DR2a or DR2b beta-chain cDNA. DR2a and DR2b represent the two isotypic DRbeta chains expressed in DR2Dw2 haplotypes. Eleven MBP-specific cytolytic T cell lines derived from patients with multiple sclerosis were isolated. Two of these cell lines recognized MBP-pulsed DR2-expressing L cell transfectants and four of them could only recognize the L cells if the adhesion molecule ICAM-1 was expressed in addition to HLA-DR2. Five of the six lines were restricted by HLA-DR2a; one line recognized Ag in conjunction with DR2b, but only if ICAM-1 was coexpressed. The remaining five lines did not lyse MBP-pulsed L cells. The ability of the DR2b molecules on transfected cells to stimulate T cells was confirmed with DR2b-allospecific T cell clones. Although five MBP-specific lines were restricted by DR2a, they recognized different parts of the MBP molecule, as demonstrated by the presentation of shorter peptides. Thus, our results suggest that DR2a is a dominant restriction molecule in MBP-specific responses by DR2+ MS patients. The results also indicate that the reported heterogeneity in MBP epitopes recognized by DR2-restricted T cells, may not be due to the use of different restriction elements but rather to the binding of different MBP peptides to DR2a molecules.
Chromatin patterns associated with lung adenocarcinoma progression (2013)

The development and progression of lung adenocarcinoma, one of the most common cancers, is driven by the interplay of genetic and epigenetic changes and the role of chromatin structure in malignant transformation remains poorly understood. We used systematic nucleosome distribution and chromatin accessibility microarray mapping platforms to analyze the genome-wide chromatin structure from normal tissues and from primary lung adenocarcinoma of different grades and stages. We identified chromatin-based patterns across different patients with lung adenocarcinoma of different cancer grade and stage. Low-grade cancers had nucleosome distributions very different compared with the corresponding normal tissue but had nearly identical chromatin accessibility. Conversely, nucleosome distributions of high-grade cancers showed few differences. Substantial disruptions in chromosomal accessibility were seen in a patient with a high-grade and high-stage tumor. These data imply that chromatin structure changes during the progression of lung adenocarcinoma. We have therefore developed a model in which low-grade lung adenocarcinomas are linked to changes in nucleosome distributions, whereas higher-grade tumors are linked to large-scale chromosomal changes. These results provide a foundation for the development of a comprehensive framework linking the general and locus-specific roles of chromatin structure to lung cancer progression. We propose that this strategy has the potential to identify a new class of chromatin-based diagnostic, prognostic and therapeutic markers in cancer progression.
Towards automated self-calibration of robot skin (2010)

This paper deals with the problem of calibrating a large number of tactile elements (i.e., taxels) organized in a skin sensor system after fixing them to a robot body part. This problem has not received much attention in literature because of the lack of large-scale skin sensor systems. The proposed approach is based on a controlled compliance motion with respect to external objects whose pose is known, which allows a robot to determine the location of its own taxels. The major contribution of this work is the formulation of the skin calibration problem as a maximum-likelihood mapping problem in a 6D space, where both the position and the orientation of each taxel are recovered. An effective calibration process is envisaged that, given a compliance control law that assures prolonged contact maintenance between a given body part and an external object, returns a maximum-likelihood estimate of detected taxel poses. Simulations validate the approach.
Glucocorticoid Receptor Counteracts Tumorigenic Activity of Akt in Skin through Interference with the Phosphatidylinositol 3-Kinase Signaling Pathway (2003)

The skin-targeted overexpression of the glucocorticoid receptor (GR) in transgenic mice dramatically impairs the inflammatory responses to tumor promoter agents and suppresses skin tumor development. The antiinflammatory, rapid effects of corticosteroids are partially exerted through interference of GR with the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway in several tissues, a highly relevant pathway in the mouse skin tumor progression process. In this work, we aimed to elucidate whether a cross-talk mechanism between GR and PI3K/Akt occurred in intact skin as well as the biological relevance of this interaction during skin tumorigenesis. We report that, in transgenic mice overexpressing the receptor, GR physically associated with p85 alpha/PI3K in skin, resulting in decreased Akt and I kappa B kinase activity. GR activation by dexamethasone in normal mouse skin also decreased Akt activity within minutes, whereas cotreatment with the GR antagonist RU486 abolished dexamethasone action. Indeed, GR exerted a nongenomic action because keratinocyte transfection with a transcriptionally defective receptor mutant still decreased PI3K and Akt activity. Moreover, GR coexpression greatly reduced the accelerated growth of malignant tumors and increased Akt activity induced by Akt-transfected keratinocytes, as shown by in vivo tumorigenic assays. Overall, our data strongly indicate that GR/PI3K-Akt cross-talk constitutes a major mechanism underlying the antitumor effect of glucocorticoids in skin.
Comparison between Internalizing Anti-HER2 mAbs and Non-Internalizing Anti-CEA mAbs in Alpha-Radioimmunotherapy of Small Volume Peritoneal Carcinomatosis Using 212Pb (2013)

These data indicate that it might be an advantage of using internalizing anti-HER2 compared with non-internalizing anti-CEA (212)Pb-labeled mAbs in the therapy of small volume xenograft tumors. They support clinical investigations of (212)Pb-mAbs RIT as an adjuvant treatment after cytoreductive surgery in patients with peritoneal carcinomatosis.
Endotoxin‐Stimulated Human Monocyte Secretion of Interleukin 1, Tumour Necrosis Factor Alpha, and Prostaglandin E<sub>2</sub> Shows Stable Interindividual Differences (1988)

The secretions of interleukin 1 (IL-1), tumour necrosis factor alpha (TNF), and prostaglandin E2 (PGE2) of low-dose E. coli lipopolysaccharide (LPS)-stimulated human monocytes (M phi) were investigated in an endotoxin (ET)-free milieu (less than 1.6 pg LPS/ml). Human M phi cultures from nine healthy men were stimulated with 0, 12.5-500, and 250,000 pg LPS/ml as measured by a very sensitive Limulus test. The IL-1 activity was tested by the mouse costimulatory thymocyte (LAF) assay, which was thoroughly standardized and characterized (interassay variation 22-24%, intra-assay variation 3-7%). Spontaneous M phi secretions of IL-1, TNF, and PGE2 were negligible, but 12.5 pg LPS/ml significantly stimulated the secretions of these M phi products and the monokine responses to 500 and 250,000 pg LPS/ml were almost in the same range. It was demonstrated that the secretions of IL-1-TNF and TNF-PGE2 were strongly correlated. Pronounced interindividual differences in LPS responsiveness were demonstrated, and two low-responders, one of whom was HLA-DR1,2-positive, were identified. Three first-degree relatives of the DR1,2-positive low-responder had similar low responses. Furthermore, M phi cultures were prepared weekly for 4 weeks from four HLA-DR different men and the only DR2,2 homozygous individual had low monokine responses. In conclusion, stable interindividual differences in in vitro monokine and PGE2 secretions of LPS-stimulated M phi were demonstrated. It is suggested that HLA-DR2-positive individuals may be low responders.
A 2 K byte fully-associative cache memory with on-chip DRAM control (1989)

A 2 kbyte cache memory with on-chip DRAM (dynamic random-access memory) control has been built. The fully-associative write-back write-allocate cache is organized as 128 lines by 16 bytes. The part directly connects to and controls an array of 1 Mb DRAMs forming a 4 Mbyte parity-checked memory subsystem. Zero-wait-state operation of the Intel 80386 microprocessor at 25 MHz is supported. Fabricated in a 2 μm CMOS process, the 374-mil×383-mil die contains 172 K transistors
GaAs–Al<i>x</i>Ga1−<i>x</i>As Double Heterostructure Injection Lasers (1971)

Double heterostructure GaAs–AlxGa1−xAs junction lasers which have very low thresholds and which have been operated continuously at and above room temperature have been fabricated by liquid phase epitaxial growth. The threshold current density of these lasers decreases approximately linearly with the thickness of the active region from 3 to at least 0.5 μm. This is interpreted as the result of near perfect carrier and optical confinement as the result of large steps in the energy gap and index of refraction at the heterojunctions in these diodes. The gain in these lasers is very high and its dependence upon current density is superlinear. Loss is very low and almost that expected from free carriers. Complete polarization of the lasing mode was observed. This latter is interpreted to be the result of an increased reflection coefficient for the T E mode.
Generation of Synthetic Copolymer Libraries by Combinatorial Assembly on Nucleic Acid Templates (2016)

Recent advances in nucleic acid-templated copolymerization have expanded the scope of sequence-controlled synthetic copolymers beyond the molecular architectures witnessed in nature. This has enabled the power of molecular evolution to be applied to synthetic copolymer libraries to evolve molecular function ranging from molecular recognition to catalysis. This Review seeks to summarize different approaches available to generate sequence-defined monodispersed synthetic copolymer libraries using nucleic acid-templated polymerization. Key concepts and principles governing nucleic acid-templated polymerization, as well as the fidelity of various copolymerization technologies, will be described. The Review will focus on methods that enable the combinatorial generation of copolymer libraries and their molecular evolution for desired function.
Base mismatch-specific endonuclease activity in extracts from<i>Saccharomyces cerevisiae</i> (1991)

An endonuclease activity (called MS-nicking) for all possible base mismatches has been detected in the extracts of yeast, Saccharomyces cerevisiae. DNAs with twelve possible base mismatches at one defined position are cleaved at different efficiencies. DNA fragments with A/G, G/A, T/G, G/T, G/G, or A/A mismatches are nicked with greater efficiencies than C/T, T/C, C/A, and C/C. DNA with an A/C or T/T mismatch is nicked with an intermediate efficiency. The MS-nicking is only on one particular DNA strand, and this strand disparity is not controlled by methylation, strand break, or nature of the mismatch. The nicks have been mapped at 2-3 places at second, third, and fourth phosphodiester bonds 5' to the mispaired base; from the time course study, the fourth phosphodiester bond probably is the primary incision site. This activity may be involved in mismatch repair during genetic recombination.
Biochemical Characteristics of Osmophilic Yeasts Isolated from Pollens and Honey (1996)

A total of 1752 strains of osmophilic yeasts were isolated from honey and pollens. Forty-three strains of osmophilic yeasts produced polyols, among which 6 strains produced erythritol in good yields. On the other hand, 52 osmophilic yeasts converted sucrose to fructooligosaccharides, among which 8 strains produced both extra and intracellular beta-fructofuranosidase, which converted sucrose to fructooligosaccharides. This investigation concluded that osmophilic yeasts converted sucrose not only to polyols, but also to fructooligosaccharides in good yields.
Ergonomic Comparison of Seven Modes of Carrying Loads on the Horizontal Plane (1971)

Abstract A comparative study of seven modes of carrying an identical load on the level ground was conducted on seven normal, healthy volunteers. The modes of carrying were: Head, Rucksack, Double Pack, Rico Bag, Sherpa, Yoke and Hands. The volunteers marched with 30 kg at the rate of 5 km/hr and the minute ventilation, oxygen consumption and pulse rate were recorded during the steady state of work and a 5 min recovery period after the work. Analysis of variance on the data established a significant (p<0·01) difference in the values of the physiological parameters of energy cost, cardiac rate and pulmonary ventilation due to a change in the mode of carrying. The Double Pack mode was ergonomically the best mode, followed closely by the Head mode. Carrying by Hands was the worst method and the others were intermediate as far as physiological economy is concerned. The merits and demerits of these modes of carrying loads are discussed briefly.
Local Positioning System Using Flickering Infrared LEDs (2017)

A minimalistic optical sensing device for the indoor localization is proposed to estimate the relative position between the sensor and active markers using amplitude modulated infrared light. The innovative insect-based sensor can measure azimuth and elevation angles with respect to two small and cheap active infrared light emitting diodes (LEDs) flickering at two different frequencies. In comparison to a previous lensless visual sensor that we proposed for proximal localization (less than 30 cm), we implemented: (i) a minimalistic sensor in terms of small size (10 cm 3 ), light weight (6 g) and low power consumption (0.4 W); (ii) an Arduino-compatible demodulator for fast analog signal processing requiring low computational resources; and (iii) an indoor positioning system for a mobile robotic application. Our results confirmed that the proposed sensor was able to estimate the position at a distance of 2 m with an accuracy as small as 2-cm at a sampling frequency of 100 Hz. Our sensor can be also suitable to be implemented in a position feedback loop for indoor robotic applications in GPS-denied environment.
“Consciência das cores”: Natalie Kalmus e o technicolor na Grã-Bretanha (2013)

Quando o Technicolor foi visto pela primeira vez nos cinemas da Gra Bretanha, ele foi recebido por uma onda de opinioes contraditorias, desde a queixa perplexa de que “com  a tela em um ardente motim de cores e impossivel se concentrar totalmente em qualquer individuo em particular” ate a alegacao de que “filmes em preto e branco em breve serao uma coisa do passado. Os modos do discurso contemporâneo a respeito da cor frequentemente abordavam o impacto das cores no publico que, temia se, poderia ser distraido por sua aparencia espetacular no contexto do cinema narrativo. Para muitos diretores, diretores de fotografia e diretores de arte, contudo, a escolha da cor demonstrava o seu fascinio como registro simbolico, como uma ferramenta para apoiar a narrativa e como tecnica expressiva. Este ensaio discute a chegada do Technicolor na Gra Bretanha e o impacto que teve sobre as praticas vigentes, bem como sobre os regimes esteticos.
Vibrate-to-unlock: Mobile phone assisted user authentication to multiple personal RFID tags (2011)

Personal RFID tags store valuable information private to their users that can easily be subject to eavesdropping, unauthorized reading, owner tracking, and cloning. RFID tags are also susceptible to relay attacks and likely to get lost and stolen. In this paper, we introduce the problem of user authentication to RFID tags. This allows users to control when and where their RFID tags can be accessed. We present a novel approach for user authentication to multiple RFID tags called “Vibrate-to-Unlock” (VtU). This technique uses a mobile phone as an authentication token, forming an unidirectional tactile communication channel between users and their RFID tags. Authenticating to an RFID tag involves touching a vibrating phone to the tag or an object carrying the tag, such as a wallet. We discuss the design and implementation of this new method on Intel's WISP tags. We also report on a preliminary usability evaluation of our VtU prototype.
A micro-radioimmunoassay for the measurement of intracellular cAMP. (1993)

We have developed a rapid and sensitive micro-radioimmunoassay for the detection of cellular cAMP. The assay employs a simple method for preparing cellular lysates that requires as few as 500 cells per data point. Cellular lysates are incubated with cAMP-specific antibody complexes and [125I]cAMP in 96-well plates, harvested onto glass fiber filters and analyzed using a commercial autoradiograph imaging system. This method provides significant savings in reagents and may be particularly useful in situations where only a limited number of cells are available.
Field-induced phase transitions in Bismuth-based perovskites: A new approach to lead-free high-strain piezoceramics (2008)

The ferroelectric and piezoelectric properties of solid solutions containing various phase fractions of bismuth sodium titanate, barium titanate and potassium sodium niobate are investigated at different temperatures. It is possible to obtain very high strain in these materials near their respective depolarization temperature. The origin of this high strain is the combination of the piezoelectric effect with a field-induced phase transition from a low-field antiferroelectric to a high-field ferroelectric phase.
Pragmatics : a reader (1991)

This is an anthology of readings on the subject of pragmatics - the study of actual utterances or 'speaker's intended meaning'. Pragmatics is relevant to a variety of disciplines and specializations, including linguistics, poetics, the philosophy of language, cognitive science, artificial intelligence, and psychology. Davis's collection brings together the most important literature on pragmatics, including classic papers as well as the work of the best contemporary theorists. The selections are organized according to such topics as conversational implicature and relevance, speaker reference, indexicals, presupposition, direct and indirect speech acts, and non-literal uses of language. Informal and philosophical, rather than formal or technical, approaches to pragmatics are emphasized.
Buspirone in major depression: a controlled study. (1991)

One hundred and fifty-five outpatients suffering from major depression with moderate anxiety entered a double-blind study comparing 8 weeks of treatment with buspirone or placebo. Thirty-four percent of buspirone and 41% of placebo patients discontinued treatment before 8 weeks. Results were consistent across all physician- and patient-completed outcome measures, with treatment response to buspirone significantly better than to placebo at treatment endpoint. Seventy percent of buspirone and 35% of placebo patients (p less than .01) were rated moderately or markedly improved after 8 weeks of therapy. Initial levels of anxiety and depression had no significant effect on treatment outcome. Buspirone was found to be safe and well tolerated at doses of up to 90 mg/day.
DNA-Based MRI Probes for Specific Detection of Chronic Exposure to Amphetamine in Living Brains (2009)

We designed phosphorothioate-modified DNA probes linked to superparamagnetic iron oxide nanoparticles (SPION) for in vivo magnetic resonance imaging (MRI) of fosB and Delta fosB mRNA after amphetamine (AMPH) exposure in mice. Specificity of both the fosB and Delta fosB probes was verified by in vitro reverse transcriptase-PCR amplification to a single fragment of total cDNA obtained from acutely AMPH-exposed mouse brains. We confirmed time-dependent uptake and retention profiles of both probes in neurons of GAD67-green fluorescent protein knock-in mice. MRI signal of SPION-labeled fosB probe delivered via intracerebroventricular route was elevated in both acutely and chronically AMPH-exposed mice; the signal was suppressed by dopaminergic receptor antagonist pretreatment. SPION-labeled Delta fosB probe signal elevation occurred only in chronically AMPH-exposed mice. The in vivo target specificity of these probes permits reliable MRI visualization of AMPH-induced differential elevations of fosB and Delta fosB mRNA in living brains.