gebhart/patrepeval huggingface dataset:
Database of Absorption and Fluorescence Spectra of >300 Common Compounds for use in Photochem<scp>CAD</scp> (2017)

The design of new molecules for photochemical studies typically requires knowledge of spectral features of pertinent chromophores beginning with the absorption spectrum (λ<sub>abs</sub> ) and accompanying molar absorption coefficient (ε, m<sup>-1 </sup> cm<sup>-1</sup> ) and often extending to the fluorescence spectrum (λ<sub>em</sub> ) and fluorescence quantum yield (Φ<sub>f</sub> ), where the fluorescence properties may be of direct relevance or useful as proxies to gain insight into the nature of the first excited singlet state. PhotochemCAD databases, developed over a period of 30 years, are described here. The previous databases for 150 compounds have been expanded to encompass 339 compounds for which absorption spectra (including ε values), fluorescence spectra (including Φ<sub>f</sub> values) and references to the primary literature have been included where available (552 spectra altogether). The compounds exhibit spectra in the ultraviolet, visible and/or near-infrared spectral regions. The compound classes and number of members include acridines (21), aromatic hydrocarbons (41), arylmethane dyes (11), azo dyes (18), biomolecules (18), chlorins/bacteriochlorins (16), coumarins (14), cyanine dyes (19), dipyrrins (7), heterocycles (26), miscellaneous dyes (13), oligophenylenes (13), oligopyrroles (6), perylenes (5), phthalocyanines (11), polycyclic aromatic hydrocarbons (16), polyenes/polyynes (10), porphyrins (34), quinones (24) and xanthenes (15). A database of 31 solar spectra also is included.
ChemInform Abstract: NONDESTRUCTIVE LOCATION OF OXIDE BREAKDOWNS ON MOSFET STRUCTURES (1973)

Abstract Durchschlagsbereiche der Oxidschicht ( ;z.B. SiO 2 ) in Metall‐Oxid‐Halbleiter‐ Feldeffekttransistoren (MOSFET) lassen sich unter Verwendung flüssiger Å cholesterischer Kristalle zusammen mit einer dünnen amorphen Kohlenstoffschicht lokalisieren.
Hexafluoroacetone azine. Reaction with cyclohexane by a radical double chain mechanism (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHexafluoroacetone azine. Reaction with cyclohexane by a radical double chain mechanismWilliam J. MiddletonCite this: J. Am. Chem. Soc. 1971, 93, 2, 423–425Publication Date (Print):January 1, 1971Publication History Published online1 May 2002Published inissue 1 January 1971https://pubs.acs.org/doi/10.1021/ja00731a019https://doi.org/10.1021/ja00731a019research-articleACS PublicationsRequest reuse permissionsArticle Views125Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A sub-luminous outburst of a transient in the Galactic globular cluster Terzan 5, possibly due to EXO 1745-248 (aka Terzan 5 X-1) (2016)

Using Swift/XRT, the Galactic globular cluster Terzan 5 was observed on 17 April 2016. During this observation, we found that the X-ray flux originating from this cluster was significantly above the normal cluster background, indicating that a possible X-ray transient was active during this XRT observation.
Predictive value of progression-related gene classifier in primary non-muscle invasive bladder cancer (2010)

We identified progression-related gene classifier that has strong predictive value for determining disease outcome in NMIBC. This gene classifier could assist in selecting NMIBC patients who might benefit from more aggressive therapeutic intervention or surveillance.
[Quantitative evaluation of the adhesive activity of Vibrio cholerae with various degrees of virulence]. (1989)

In the studies on the evaluation of V. cholerae adhesion on suckling rabbits by our method, the adhesive activity of the vibrios has been found to be directly related to their virulence. This method may be used as an additional test for the differentiation of virulent and avirulent V. cholerae.
Development of a network/multimedia projector system (2002)

The primary objective of this paper is the study of the design and development of the SXGA network and multimedia high-resolution large screen projector system specifically designed to hook to and operate from an intranet or Web connection. The main electronic components of this projector are three LCOS panels, a video decoder, a dual interface and a image processor with advanced video processing for the next generation front projector. The basic structure and issues in the implementation of the next generation networkable multimedia projector which displays computer images from VGA to SXGA and supports NTSCr PAL video sources with a 4:3 aspect ratio and 16:9 aspect ratio sources such as DVD or HDTV are discussed.
The Recombinant Expression of Full-length Type VII Collagen and Characterization of Molecular Mechanisms Underlying Dystrophic Epidermolysis Bullosa (2002)

Type VII collagen is a major component of anchoring fibrils, attachment structures that mediate dermal-epidermal adherence in human skin. Dystrophic epidermolysis bullosa (DEB) is an inherited mechano-bullous disorder caused by mutations in the type VII collagen gene and perturbations in anchoring fibrils. In this study, we produced recombinant human type VII collagen in stably transfected human 293 cell clones and purified large quantities of the recombinant protein from culture media. The recombinant type VII collagen was secreted as a correctly folded, disulfide-bonded, helical trimer resistant to protease degradation. Purified type VII collagen bound to fibronectin, laminin-5, type I collagen, and type IV collagen and also supported human dermal fibroblast adhesion. In an attempt to establish genotype-phenotype relationships, we generated two individual substitution mutations that have been associated with recessive DEB, R2008G and G2749R, and purified the recombinant mutant proteins. The G2749R mutation resulted in mutant type VII collagen with increased sensitivity to protease degradation and decreased ability to form trimers. The R2008G mutation caused the intracellular accumulation of type VII collagen. We conclude that structural and functional studies of in vitro generated type VII collagen mutant proteins will aid in correlating genetic mutations with the clinical phenotypes of DEB patients.
Optimal and scalable distribution of content updates over a mobile social network (2009)

We study the dissemination of dynamic content, such as news or traffic information, over a mobile social network. In this application, mobile users subscribe to a dynamic-content distribution service, offered by their service provider. To improve coverage and increase capacity, we assume that users share any content updates they receive with other users they meet. We make two contributions. First, we determine how the service provider can allocate its bandwidth optimally to make the content at users as "fresh" as possible. More precisely, we define a global fairness objective (namely, maximizing the aggregate utility over all users) and prove that the corresponding optimization problem can be solved by gradient descent. Second, we specify a condition under which the system is highly scalable: even if the total bandwidth dedicated by the service provider remains fixed, the expected content age at each user grows slowly (as log(n)) with the number of users n. To the best of our knowledge, our work is the first to address these two aspects (optimality and scalability) of the distribution of dynamic content over a mobile social network.
Relationship between migraine and cardiac and pulmonary right-to-left shunts (2001)

A relationship between migraine with aura and the presence of right-to-left shunts has been reported in two studies. Right-to-left shunts are also associated with some forms of decompression illness. While conducting research in divers with decompression illness, it was our impression that divers with a large shunt often had a history of migraine with aura in everyday life and after dives. Therefore we routinely asked all divers about migraine symptoms. The medical records of the last 200 individuals referred for investigation of decompression illness were reviewed to determine the association between right-to-left shunts and migraine aura after diving, and migraine in daily life unconnected with diving. Migraine with aura in daily life unconnected with diving occurred significantly more frequently in individuals who had a large shunt which was present at rest (38 of 80; 47.5%) compared with those who had a shunt which was smaller or only seen after a Valsalva manoeuvre (four of 40; 10%) or those with no shunt (11 of 80; 13.8%) (P<0.001). Hemiplegic migraine occurred in 10 divers, each of whom had a shunt that was present at rest; in eight of these cases the shunt was large. The prevalence of migraine without aura was similar in all groups. Post-dive migraine aura was significantly more frequent in individuals who had a large shunt present at rest (21 of 80; 26.3%) compared with those who had a shunt that was smaller or only seen after a Valsalva manoeuvre (five of 40; 12.5%) or no shunt (one of 80; 1.3%) (P<0.001). Thus individuals with a large right-to-left shunt have an increased prevalence of migraine with aura in daily life unconnected with diving, and they also have an increased incidence of migraine aura after dives, but only when the dives liberate venous bubbles. These data suggest the possibility that, in some individuals, right-to-left shunts have a role in the aetiology of migraine with aura. The observations suggest that paradoxical gas embolism may precipitate migraine with aura.
Multiple fuel firing experience in a circulating fluidized bed boiler (1992)

This paper discusses the operating experience of a Foster Wheeler Energy Corporation Circulating Fluidized Bed boiler at Manitowoc Public Utilities, Wisconsin. The boiler is designed to fire a variety of fuels including 100% coal, 100% petroleum coke, and tire-derived-fuel (TDF) as a supplementary fuel. The optimization of the unit during the initial firing of petroleum coke and TDF, and long term observations are detailed in this paper.
Nuclear translocation of GAPDH–GFP fusion protein during apoptosis (1999)

Increased expression and nuclear accumulation of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) are early, critical events in several forms of apoptosis. In order to investigate the subcellular trafficking of GAPDH in vivo, the localization of a GAPDH-green fluorescent protein (GFP) fusion was studied in PC12, HEK 293 and COS-1 cells. In control cells, fusion protein autofluorescence was largely restricted to the cytoplasm, rather than the nuclear concentration favored by GFP alone. In contrast, as early as 30 min after an insult, nuclear fluorescence increased in all cell lines studied. The fusion protein redistribution paralleled the dynamics of endogenous GAPDH. These data suggest that some nuclear GAPDH observed during apoptosis represents protein previously resident in the cytosol. This construct provides an in vivo monitor for an early change in apoptosis.
铬革屑酶法提取胶原蛋白制备高分子量产物——II．凝胶的改性（续） (2005)

3.7 Molecular weight determination Protein molecular weights were estimated by SDS-PAGE (polyacrylamide gel electrophoresis in sodium dodecyl sulfate) using precast 4-15 percent gradient gels. A broad range SDS-Standard (BRM) calibration standard (Bio-Rad, Hercules,CA), which contains a mixture of nine proteins ranging in size from 6,500 to 200,000 Daltons,was used.
Suppression of Dual Specificity Phosphatase I Expression Inhibits Hepatitis C Virus Replication (2015)

It was reported that dual specificity phosphatase 1 (DUSP1) is specifically upregulated in the liver of patients with chronic hetpatitis C virus (HCV) infection who do not respond to peginterferon (PegIFN) treatment. Here, we have investigated the role of DUSP1 in HCV replication in hepatoma cells stably expressing the full HCV replicon (FK). DUSP1 was silenced in cells harboring the FK replicon using a lentiviral vector encoding a DUSP1-specific short hairpin RNA (LV-shDUSP1). We demonstrated that knock-down of DUSP1 significantly inhibited HCV RNA and protein expression. Also, DUSP1 silencing enhanced the expression of phosphorylated signal transducer and activator of transcription 1 (phosho-STAT1) and facilitated the translocation of STAT1 into the nucleus. The mRNA expression levels of myxovirus resistance protein A (MxA), 2'-5'-oligoadenylate synthetase 1 (OAS1), ISG15 ubiquitin-like modifier (ISG15), chemokine C-X-C motif ligand 10 (CXCL10), and ubiquitin-specific protease 18 (USP18) were also accelerated by silencing of DUSP1. Furthermore, combined with the IFN treatment, DUSP1 silencing synergistically decreased the levels of HCV RNA. These results suggest that suppression of DUSP1 expression enhances phosphorylation and nuclear translocation of STAT1, resulting in increasing expression of interferon-stimulated genes (ISGs), which synergizes with IFN's antiviral effect against HCV. In conclusion, DUSP1 is involved in the antiviral host defense mechanism against a HCV infection and thus DUSP1 might be a target to treat chronic HCV infection.
Absorption Properties of Coatings: A Selected Overview of Absorption Criteria Derived from Recent Pore Network Modelling (2005)

Abstract Absorption of fluids into porous media controls the printability characteristics of coated papers in respect to ink setting rate and phenomena such as wicking and bleeding. The dynamic of absorption is related to the runnability on printing presses. Pore structure, size distribution, and surface chemistry are the parameters which can be used to design structures for optimal absorption. To achieve a working understanding it has been necessary to develop the theory of absorption to encompass the short timescale fast absorption occurring during wetting of the fluid ink onto the surface of the paper. The phenomena of fluid spread and absorption are studied and shown to depend on the observed pore size distribution rather than porosity alone. This finding calls into question the traditional acceptance of the Lucas–Washburn relationship for such porous networks as the hydraulic absorption radius determined from experimental absorption rate measurements fails to follow the actual measured pore size trend. It is necessary to invoke the concept of a preferred pathway of absorption in which only selected groups within the finest connecting pores or throats of the network in combination with intermediate pore reservoirs contribute maximally to the transmission of fluid through the coating structure as porosity increases. By defining the pore size range involved in this mechanism using an inertial wetting term, found in the short time solution to the Bosanquet equation, it is possible for the first time to identify the connective structures responsible for the important time dependent absorption properties of coatings and their relationship to the ink tackification and/or setting rates for a range of printing ink solvents and diluents, including offset, rotogravure, flexographic, and ink jet inks. Additionally, the differential chromatographic effect of coatings and associated binder systems results in further time dependent offset ink setting phenomena in which miscible ink oils of different natures separate within the coating pores and between the pores and synthetic latex binders. In situ determination of the viscosity and solids content of an offset ink via static ink tack measurements allows the dynamic of ink setting to be studied on real coating systems. Combining these criteria, the necessary steps can be followed to design the coating pigment structures required for optimising existing and future fluid‐based printing technologies.
822. Oxygen heterocycles. Part VI. Orientation in the substitution of 2-methoxydibenzofuran (1956)

Cl. Routier, Ng. Ph. Buu-Hoï and R. Royer, J. Chem. Soc., 1956, 4276 DOI: 10.1039/JR9560004276
New paradigms for the integration of yaw stability and rollover prevention functions in vehicle stability control (2012)

The integration of rollover prevention and yaw stability control objectives in electronic stability control (ESC) has traditionally been done based on a priority calculation. The control system nominally focuses on yaw stability control until a danger of rollover is detected. When a danger of rollover is detected, the control system switches from yaw stability control to rollover prevention. This paper focuses on an integrated ESC system wherein the objectives of yaw stability and rollover prevention are addressed simultaneously, rather than one at a time. First, we show that staying on a desired planar trajectory at a specified speed results in an invariant rollover index. This implies that rollover prevention can be achieved whenever there is a danger of rollover only by reducing vehicle speed, since changing the desired vehicle trajectory is not a desirable option. In this regard, it is shown that a vehicle that reduces its speed before entering a sharp curve performs significantly better than a vehicle that uses differential braking during the turn for yaw stability control. Second, this paper explores how the use of steer-by-wire technology can address the tradeoff between yaw stability, speed, and rollover prevention performance. It is shown that the use of traditional steer-by-wire simply as an additional actuator cannot by itself ameliorate the tradeoff. However, this tradeoff can be eliminated if steer-by-wire is used to invert the direction of the roll angle of the vehicle. A new steer-by-wire algorithm that uses transient countersteering is shown to change the location of the rollover dynamics from the neighborhood of an unstable to a stable equilibrium. In this case, a desired trajectory can indeed be achieved by the vehicle at the same speed with a much smaller danger of rollover. This is a novel and viable approach to integrating the yaw stability and rollover prevention functions and eliminating the inherent tradeoffs in the performance of both.
Multi-conformational Ligand Representation in 4D-QSAR: Reducing the Bias Associated with Ligand Alignment (2000)

Quantitative structure-activity relationship (QSAR) is an area of computational research which builds mathematical or atomistic models to predict biological activities of molecules. While more powerful approaches make use of a genetic algorithm to reduce the bias with respect to model construction, the predictive power of the resulting surrogate still critically depends on the spatial alignment of the ligand molecules used to construct it. The 4D-QSAR concept Quasar developed at our laboratory not only takes local induced fit and H-bond flip-flop into account but also allows for the representation of the ligand molecules by an ensemble of conformations and/or orientations. The contribution of a single entity within this ensemble to the total ligand-receptor interaction energy is determined by a Boltzmann criterion. The three-dimensional surrogate is represented by a family of receptor-surface models, populated with atomistic properties—hydrogen bonds, salt bridges, hydrophobic particles, and solvent—mapped onto it. Quasar has been used to establish QSARs for the enzyme dopamine β-hydroxylase and for the aryl hydrocarbon receptor. The surrogates were able to predict free energies of ligand binding, ΔG°, for external sets of 15 and 26 test ligand molecules, respectively, to within 0.7 kcal/mol (rms) of the experimental value, with the largest individual deviation not exceeding 1.3 kcal/mol. The results indicate that the use of a multiple-ligand representation is superior to a single-conformer concept and reduces the user bias associated with the ligand alignment. Moreover, the selection protocol demonstrates that the technique is capable of identifying a small number of active conformations and does not prefer a larger selection of lesser-contributing entities.
A Highly Efficient and Scalable Model for Crossbar Arrays with Nonlinear Selectors (2018)

A scalable crossbar array model is proposed to solve arrays with various sizes and device characteristics. Computation is accelerated >1000× by array reduction, enabling array scaling analysis and extensive design space exploration. Computation errors can be reduced by extrapolation from calculations with different array reduction ratios. The impact of selectors on array performance is analyzed with this model, which can be applied to nonlinear, threshold switch, and rectifying selectors.
Pleiotropic Effects of Adaptation to a Single Carbon Source for Growth on Alternative Substrates (1999)

It is frequently assumed that populations of genetically modified microorganisms will perform their intended function and then disappear from the environment due to inherent fitness disadvantages resulting from their genetic alteration. However, modified organisms used in bioremediation can be expected to adapt evolutionarily to growth on the anthropogenic substrate that they are intended to degrade. If such adaptation results in improved competitiveness for alternative, naturally occurring substrates, then this will increase the likelihood that the modified organisms will persist in the environment. In this study, bacteria capable of degrading the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) were used to test the effects of evolutionary adaptation to one substrate on fitness during growth on an alternative substrate. Twenty lineages of bacteria were allowed to evolve under abundant resource conditions on either 2,4-D or succinate as their sole carbon source. The competitiveness of each evolved line was then measured relative to that of its ancestor for growth on both substrates. Only three derived lines showed a clear drop in fitness on the alternative substrate after demonstrable adaptation to their selective substrate, while five derived lines showed significant simultaneous increases in fitness on both their selective and alternative substrates. These data demonstrate that adaptation to an anthropogenic substrate can pleiotropically increase competitiveness for an alternative natural substrate and therefore increase the likelihood that a genetically modified organism will persist in the environment.
Pacemaker lead infection: report of three cases and review of the literature (1999)

Pacemaker lead infection is a rare condition, most often occurring when intervention is needed after pacemaker implantation. Diagnosis is by blood cultures and confirmation by transoesophageal echocardiography; transthoracic echocardiography is often inadequate. A literature review indicated the microorganism most responsible for late lead infection is Staphylococcus epidermidis (which can grow on plastic material). A retrospective analysis of patient files from the authors' institution (1993-97) yielded three patients with proven pacemaker lead endocarditis. The diagnosis of pacemaker endocarditis was by transoesophageal echocardiography. The endocarditis appeared after a long period and in two of the three patients there was S epidermidis infection. Thoracotomy with removal of the infected system was performed because of the large dimensions of the vegetations. A new pacemaker was implanted: in one patient with endocardial leads, in the other two with epicardial leads. All three patients recovered well and follow up was uneventful for at least one year.