gebhart/patrepeval huggingface dataset:
Isolation and Characterization of Human Factor VIII (Antihemophilic Factor) (1973)

Factor VIII (antihemophilic factor) has been purified approximately 500-fold from the cryoprecipitate fraction of human plasma. The isolation procedure involves adsorption of contaminants with A1(OH)3, column chromatography on tricalcium citrate-cellulose, precipitation with concanavalin A, and an agarose gel filtration step. The final product is homogeneous when examined by zone electrophoresis, sedimentation equilibrium, and immunoelectrophoresis. The molecular weight determined by sedimentation equilibrium is 1.12 million ± 98,000. After reduction of the protein with 2-mercaptoethanol or dithiothreitol, subunits are formed which migrate as one band in polyacrylamide gel electrophoresis and zone electrophoresis. The subunits are heterogeneous, however, in the ultracentrifuge, apparently due to substantial aggregation. The smallest species which could be detected has a molecular weight of 105,000 ± 5,000. The molecular weight of the subunit determined by sodium dodecyl sulfate (SDS) gel electrophoresis was 240,000. The latter value may be high, however, due to the fact that human Factor VIII contains approximately 6% carbohydrate (hexose, hexosamine, and neuraminic acid) and the molecular weights of glycoproteins determined by SDS gel electrophoresis tend to be high. Antibodies prepared in rabbits against human Factor VIII inhibit both human and bovine Factor VIII activity. Antibodies to the highly purified human Factor VIII also form a precipitin line in immunoelectrophoresis experiments with the cryoprecipitate fraction prepared from hemophilic plasma, indicating that an abnormal Factor VIII molecule is present in the plasma of individuals with classic hemophilia. Other general properties of human Factor VIII, including its amino acid composition, thrombin modification, and turnover in hemophilic dogs, are also reported.
A 5 kV nanosecond-risetime pulse generator gating an electro-optical shutter (1984)

A 5 kV pulse generator has been developed using avalanche transistors. This generator produces 5 kV fixed pulse amplitudes with 10 ns total risetime and 10 mu s duration, to drive a proximity focus image intensifier. The pulse generator operates at repetition rates up to 250 Hz. The trigger pulse is galvanically decoupled from the pulse generator using a commercial optocoupler which is also driven in the avalanche region.
Intracerebral transplantation of autologous adipose‐derived stem cells for chronic ischemic stroke: A phase I study (2021)

Current therapy does not provide significant benefits for patients with chronic stroke. Pre-clinical studies suggested that autologous adipose-derived stem cells have benefits for the treatment of chronic stroke. This Phase I open-label study was conducted to demonstrate the safety and efficacy of autologous adipose-derived stem cells (GXNPC1) in chronic stroke. Three patients with chronic stroke were treated with stereotactic implantation of autologous adipose-derived stem cells (1 × 10<sup>8</sup> cells). The primary endpoints of safety evaluation included adverse events, over a 6 months post-implantation period. The secondary endpoints included improvements in neurological functions. Evolutional change of brain parenchyma was also followed with magnetic resonance imaging (MRI). All three participants improved significantly at 6 months follow-up. The extent of improvement from pre-treatment was: National Institutes of Health Stroke Scale improved 5-15 points, Barthel Index: 25-50 points, Berg balance scale 0-21 points and Fugl-Meyer modified sensation 3-28 points. All three patients had signal change along the implantation tract on MRI one month after surgery. There is no related safety issue through 6 months observation. Clinical measures of neurological symptoms of these patients with chronic stroke improved at 6 months without adverse effects after implantation of autologous adipose-derived stem cells (GXNPC1), which might be correlated with post-implantation changes on brain MRI. Clinical Trial Registration-URL: https://clinicaltrials.gov/ct2/show/NCT02813512?term=ADSC&cond=Stroke&cntry=TW&draw=2&rank=1 Unique identifier: NCT02813512.
A preliminary investigation of acoustic energy transmission from a tapered fluid layer into a fast bottom (1976)

The transmission of acoustic energy from a tapered fluid layer into an underlying layer of fluid was investigated. Pulsed transmissions at frequencies of 75.85 kHz and 107.5 were used to insonify the upper layer while a small probe transducer was used to measure signal amplitude variation with depth in the lower layer. The experimental data collected indicate that a directional transmission of acoustical energy into the lower layer occurs over regions corresponding to the individual cutoff depths for normal modes in the upper layer. A simple method for estimating the position of these regions is discussed and the effects of frequency and upper layer slope variations are reported. (Author)
Modeling and simulation of hard-particle interaction in head/disk interfaces (2005)

A hard particle interacting with a slider and a disk in the head/disk interface of hard-disk drives can produce a scratch on the disk and result in data loss. Our work emphasizes modeling and simulation of slider, particle, and disk interactions, scratch generating mechanisms, and linking of scratch to interface design parameters. Two models are presented. The Monte Carlo method was used to calculate scratch probabilities and parametric studies were performed to determine the effect on scratch probability of various parameters, such as friction coefficients, particle mean size, slider wall angles, the ion-milling (IM) etch depth from the air-bearing surface (ABS) of the slider, and the efficacy of additional ABS structures acting as particle shields. Simulation results show that the friction coefficient is a dominant parameter. If the disk friction coefficient is smaller than the slider friction coefficient, scratches are not produced. Using shallow IM depths is an effective and practical way to reduce the scratch probability. Experimental results are very close to the simulation predictions.
Reconstruction of depth profiles of thermal conductivity of case hardened steels using a three-dimensional photothermal technique (2008)

A method of retrieving thermophysical depth profiles of continuously inhomogeneous materials is presented both theoretically and experimentally using laser infrared photothermal radiometry. This method represents the three-dimensional (3D) extension of earlier one-dimensional thermal-wave inverse-problem techniques for reconstructing inhomogeneous thermal-conductivity or diffusivity depth profiles. A 3D theoretical model suitable for characterizing solids with arbitrary continuously varying thermophysical property depth profiles and finite (collimated or focused) laser beam spotsize is developed. A numerical fitting algorithm to retrieve the thermophysical profile was demonstrated with three case hardened steel samples. The reconstructed thermal conductivity depth profiles were found to be well anticorrelated with microhardness profiles obtained with the conventional indenter method.
Biological activities of antitrinitrophenyl and antidinitrophenyl mouse monoclonal antibodies. (1982)

The biological activities of mouse IgG1, IgG2a, IgG2b, and IgE monoclonal were investigated. As has been shown with conventional antibodies, monoclonal IgG1 and IgE are the two classes capable of sensitizing the mouse for anaphylactic reactions, IgE sensitizes the rat, and IgG2a sensitizes the guinea pig. What has not been seen with conventional antibodies is that large amounts of monoclonal IgG2a or IgG2b can sensitize the mouse, very large amounts of monoclonal IgE can sensitize the guinea pig, and very large amounts of IgG1 and IgG2a can sensitize the rat. One of the IgG1 monoclonal antibodies was capable of fixing complement by the classical pathway.
A new record for Herimosa albovenata (waterhouse) (Lepidoptera: Hesperiidae) in the central-west slopes and plains of New South Wales (2014)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
LIGATURE CARRIER SPECIFICALLY DESIGNED FOR TRANSVAGINAL SACROSPINOUS COLPOPEXY (1997)

In Brief A new ligature carrier designed for sacrospinous colpopexy permits bite acquisition to be performed under direct surgical visualization within the confines of the pararectal space. In addition, it permits ample penetration of the sacrospinous ligament through the coccygeus muscle, without restriction of suture type, size, or number of sutures per bite. As part of site-specific reconstructive pelvic surgery, we have performed sacrospinous colpopexy using this ligature carrier in 71 patients with genital prolapse. We have encountered no operative complications from the use of this ligature carrier. A new ligature carrier is designed specifically for sacrospinous colpopexy.
On Impeaching Presidents (1999)

The constitutional tragedy-or was it farce?-that the nation went through at the end of the millennium was literally unprecedented. Never before had a duly elected President been impeached by the House and tried by the Senate. (Andrew Johnson, it must be recalled, became President by dint of one man's bullet, rather than all men's ballots.) These momentous events raised profound constitutional questions for politicians, journalists, and, ultimately, ordinary Americans in whose name our government governs.
Development of enhanced multiport network analyzer calibrations using non-ideal standards (2005)

An Improved Short-Open-Load-Reciprocal (SOLR) Vector Network Analyzer (VNA) calibration is developed and validated. Through the use of a more complex load model the usable frequency range of the SOLR calibration algorithm is expanded. Comparisons are made between this new calibration and existing calibration techniques that are known to be accurate at high frequencies. The Anritsu 37xxx Lightning series 65GHz VNA is used as the principle measurement tool for calibration comparison and verification. This work is built off of previous work done at USF in which it is shown that the Short-Open-Load-Thru (SOLT) calibration’s accuracy improves through the implementation of more complex load and thru models.\nOne of the most significant advantages of the SOLR calibration algorithm is that it does not require an ideal well behaved thru standard. This is extremely useful in multiport probing environments where it is often necessary for speed and space conservation purposes to use loopback thrus or other non-ideal transmission structures during calibration. Multiport test equipment and measurement techniques are highlighted and discussed. A general n-port expansion of a two-port calibration algorithm is presented and used to adapt the improved two-port SOLR algorithm to a four-port calibration. In doing so a theoretical development that addresses error model treatment, and switch term corrections is presented that includes an improved set of the redundancy equations that enable the multiport SOLR algorithm.\nThe algorithm uses a four-port SOL calibration at each port and then determines the remaining error terms by measuring a minimal set of reciprocal passive standards. The four-port SOLR algorithm developed was illustrated through the use of a four-port test set that consists of a two-port VNA input multiplexed to four-ports through an RF switch array. Verification of the four-port SOLR calibration is made by comparing it to available four-port calibration techniques using available on-wafer test structures. As another promising advance of the work the possibility of using of a multiport reciprocal standard is shown to have potential for reducing the number of standard connections needed to accomplish multiport SOLR calibration. Differential measurements are facilitated through mixed-mode calculations of single ended S-parameter measurements made with the four-port SOLR calibrations improved with this work.
Mitochondrial-genome-encoded RNAs: differential regulation by corticotropin in bovine adrenocortical cells. (1993)

Differential screening of an adrenal cortex cDNA library for corticotropin (ACTH)-inducible genes led to the isolation of a group of cDNAs representing mitochondrial genes that encode subunits of cytochrome oxidase, ATPase, and NADH dehydrogenase. Northern blot analysis of RNA from cells stimulated by ACTH confirmed the induction of these genes by ACTH yet revealed major differences in the relative responses of the respective mRNAs. The levels of mRNAs for cytochrome oxidase subunit I and ATPase increased 2- to 4-fold and for NADH dehydrogenase subunit 3 increased 20-fold, whereas the levels of the mitochondrial 16S rRNA showed no change within 6 h of ACTH stimulation. These effects of ACTH on mitochondrial mRNA levels probably result from both activation of the H2 transcription unit that encodes mitochondrial mRNAs and alteration of mRNA stability. ACTH also increased the activity of cytochrome oxidase after 12 h of stimulation. Examination of the tissue specificity of expression of five mitochondrial genes showed a wide range of RNA levels among 11 tissues but high correlations between individual RNA levels, consistent with a coordinated expression of the mitochondrial genes, although at different levels in each cell type. Proportionately high levels of mitochondrial mRNAs were found in adrenal cortex, probably reflecting a stimulatory effect of ACTH in vivo. Overall, the results indicate that ACTH enhances the energy-producing capacity of adrenocortical cells.
Colorimetric Determination of Carboxylic Acid Derivatives as Hydroxamic Acids (1958)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTColorimetric Determination of Carboxylic Acid Derivatives as Hydroxamic AcidsVivian. Goldenberg and P. E. SpoerriCite this: Anal. Chem. 1958, 30, 8, 1327–1330Publication Date (Print):August 1, 1958Publication History Published online1 May 2002Published inissue 1 August 1958https://pubs.acs.org/doi/10.1021/ac60140a008https://doi.org/10.1021/ac60140a008research-articleACS PublicationsRequest reuse permissionsArticle Views521Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
New Perspectives on Microsoft Office Access 2007, Comprehensive, Premium Video Edition (2010)

Market leading text, NEW PERSPECTIVES ON MICRSOFT OFFICE ACCESS 2007 now comes with video! The tutorial videos focus on the most important or difficult concepts and skills, helping you better engage in and retain information. With the text's critical thinking, case-based approach you understand why you're learning what you're learning, and are prepared to easily transfer skills to new situations.
Large grain polycrystalline silicon films on graphite for solar cell applications (1984)

Polycrystalline silicon layers are investigated on low cost graphite substrates. A closed space CVD deposition technique is used to deposit a highly doped Si-layer of 20 ..mu..m thickness on a polished graphite substrate. To improve the crystallize size the Si-film is recrystallized by means of a moving tungsten filament. The recrystallized silicon layer acts as a selective bulk contact and as a growing matrix for the active layer, which is deposited in a second CVD process. SIS-solar cells made with spray pyrolysis of SnO/sub 2/ give efficiencies between 7 and 9%.
[The role of bacterial adhesion in urinary tract infections]. (1993)

Bacteria adhere to and colonize almost any surface. The mechanism by which bacteria interact with the mucosal surface appears to involve specific molecular ligands or adhesins on the surface of the bacteria that interlock with specific receptor molecules on the surface to be colonized. Material adhesion allows the microorganisms to resist being washed away by the fluids and secretions that bathe mucosal surfaces and is a necessary prerequisite to growth, colonization, and subsequent infection. Many examples of the role of bacterial adherence to tissues of the host have been reported in the literature. The classic study is that of Smith and Linggood, who demonstrated that toxin-producing enteropathogenic Escherichia coli, which cause diarrhoea in swine, adhere selectively to the mucosal surfaces of the small intestine. Adherence is mediated by hair-like pili projecting from the surface of the cells. Production of these pili is controlled by a specific plasmid, the loss of which renders the cells avirulent although they continue to produce toxin. In addition, antibody to the pilus antigen prevents adherence and protects piglets against challenge with the piliated organisms. Thus, the adhesin is an essential virulence factor in enteropathogenic E. coli infections in swine. Similar studies in a variety of diseases including enterotoxigenic E. coli infections in men and rheumatic fever support the concept that specific bacterial adherence to host tissues is an important characteristic of many pathogenic microorganisms.
SRI-Sarnoff AURORA System at TRECVID 2012 Multimedia Event Detection and Recounting. (2012)

In this paper, we describe the evaluation results for TRECVID 2012 Multimedia Event Detection (MED) and Multimedia Event Recounting (MER) tasks as a part of SRI-Sarnoff AURORA system that is devel-oped under the IARPA ALDDIN program. In AURORA system, we incorporated various low-level fea-tures that capture color, appearance, motion, and audio information in videos. Based on these low-level features, we developed Fixed-Pattern and Object-Orientated spatial feature pooling, which result in signif-icant performance improvement to our system. In addition, we collected more than 1800 concepts and designed a set of concept pooling approaches to build the Concept Based Event Representation (CBER, i.e., high-level features). We submitted six runs exploring various fusions of low-level features, high-level features, and ASR/OCR features for MED task. All runs achieve satisfactory results. In particular, two EK10Ex runs for both pre-specified events (PS-Events) and ad-hoc events (AH-Events) obtain relatively better results. In MER task, we developed an approach to provide a breakdown of the evidences of why the MED decision has been made by exploring the SVM-based event detector. Furthermore, we designed evidence specific verification and detection to reduce uncertainty and improve key evidence discovery. Our MER evaluation results for MER-to-Event are very good.
In situ Hybridization for the Detection of Chicken Anemia Virus in Formalin-Fixed, Paraffin-Embedded Sections (1993)

The development of a biotinylated in situ hybridization procedure for the detection of chicken anemia virus (CAV) is described. A double-stranded DNA probe was prepared using polymerase chain reaction and was biotinylated by nick translation. Hybridization conditions included the use of a microwave oven to denature target and probe nucleic acids and a five-step protocol for detection of biotinylated hybrids. In situ hybridization detected CAV nucleic acid in thymus tissue from experimentally infected birds after 6 hours, 3 days, and 7 days fixation time in formalin. However, immunocytochemical detection of CAV antigen was severely impaired if tissue was fixed in formalin for more than 6 hours.
TOP-OF-RAIL FRICTION CONTROL SYSTEM PERFORMANCE UPDATE (2004)

This article presents an update on systems to control top-of-rail (TOR) friction by applying lubricants to reduce curving forces, train energy and rail/wheel wear. Applications include wayside, hi-rail and locomotive-based systems. Locomotive-based applications show the most promise for system-wide benefits, but difficulties in making the equipment reliable have led operators to depend on wayside and hi-rail systems for specific locations. Key areas where additional research is needed include wayside applicator spacing, product durability, and cutting the number of gauge-face lubricators. Locomotive-based systems need development in reliability, ease of operation and compatibility with other locomotive systems. The article reports on issues involving all of these: gauge-face lubrication vs. TOR; spacing; wayside and locomotive-based systems. It also includes references and summary of TOR system implementation requirements and issues.
Die Zukunft - Definition von Subtypen aus dem Formenkreis der Multiplen Sklerose (2001)

Multiple Sklerose ist keine homogene Krankheitsentität, sondern ein heterogener Formenkreis entzündlich-demyelinisierender ZNS-Erkrankungen mit variablen klinischen Verläufen und vor allem unterschiedlichem, nicht prognostizierbarem Ansprechen auf therapeutische Interventionen. Rezente neuropathologische Erkenntnisse haben ein Umdenken in der immunpathogenetischen Betrachtung der Multiplen Sklerose eingeleitet. Die Heterogenität der Multiplen Sklerose erfordert eine zukünftig differenziertere Subtypisierung der Patienten nach genetischen, klinischen, neuroradiologischen, neuropathologischen und neuroimmunologischen Parametern. Damit wäre es erstmals möglich, Patienten nach einem differentialtherapeutischen Konzept spezifisch für eine individuelle Therapie zu selektionieren und damit den Erfolg bisheriger Therapiestrategien drastisch zu verbessern.
Copyright & Privacy - Through the Wide-Angle Lens, 4 J. Marshall Rev. Intell. Prop. L. 285 (2005) (2005)

Some have proposed “alternative compensation schemes” as a means of compensating copyright owners and creators for P2P activity while avoiding litigation. Some have proposed a streamlined dispute resolution system that would allow for enforcement in a manner analogous to the UDRP model. Others question whether private copying should necessarily be viewed as illegal and whether any alternative compensation scheme is viable. With all of these proposals, the question remains as to whether “alternative compensation” is really alternative.
An improved and simplified radioisotopic assay for the determination of free and esterified carnitine (1976)

The radioisotopic assay for carnitine first described by Cederblad and Lindstedt (Clin. Chim. Acta. 37:235-543, 1972) and modified by Bohmer et al (Clin. Chim. Acta. 57:55-61, 1974) has been improved and simplified. As a result, the assay yields a linear response over a wide range of carnitine concentrations without the need for excessive amounts of labeled acetyl-CoA. In addition, it will measure very small quantities of carnitine even in the presence of excess acylcarnitine. The method allows rapid determination of free and esterified carnitine in small volumes of plasma (50 mul is sufficient) without the need for prior deproteinization of the samples.
Elevated Plasma Levels of Homocysteine inParkinson’s Disease (1998)

Significantly elevated plasma levels of homocysteine, but not cysteine and cysteinylglycine, were found in treated parkinsonian patients compared to controls. Elevated levels of homocysteine may be either caused by an unknown endogenous metabolic disturbance or by antiparkinsonian treatment, because no association to severity or duration of disease was found. Based on the results of this study one may speculate that homocysteine may be an independent risk factor for vascular disease in Parkinson's disease.