gebhart/patrepeval huggingface dataset:
The Preparation of Some Substituted Thiohydantoins and Thioimidazoles (1948)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Preparation of Some Substituted Thiohydantoins and ThioimidazolesMary Jackman, Mabel Klenk, B. Fishburn, B. F. Tullar, and S. ArcherCite this: J. Am. Chem. Soc. 1948, 70, 9, 2884–2886Publication Date (Print):September 1, 1948Publication History Published online1 May 2002Published inissue 1 September 1948https://pubs.acs.org/doi/10.1021/ja01189a015https://doi.org/10.1021/ja01189a015research-articleACS PublicationsRequest reuse permissionsArticle Views481Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Rotation of phenyl rings in metal complexes of substituted tetraphenylporphyrins (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRotation of phenyl rings in metal complexes of substituted tetraphenylporphyrinsS. S. Eaton and G. R. EatonCite this: J. Am. Chem. Soc. 1975, 97, 13, 3660–3666Publication Date (Print):June 1, 1975Publication History Published online1 May 2002Published inissue 1 June 1975https://pubs.acs.org/doi/10.1021/ja00846a016https://doi.org/10.1021/ja00846a016research-articleACS PublicationsRequest reuse permissionsArticle Views1024Altmetric-Citations132LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Ascend Tunnel Management Protocol - ATMP (1997)

This document specifies a generic tunnel management protocol that allows remote dial-in users to access their home network as if they were directly attached to the home network. The user's client software uses an address contained in the home network address space for the remote access. Packets to and from the home network are tunneled by the Network Access Server (NAS) to which the user connects and a Home Agent (HA) on the user's home network. This allows for the support of access to Virtual Private Networks and also allows for the use of protocols other than IP to be carried over the tunnel. An example of how the RADIUS (Remote Authentication Dial In User Service) can be used to provide the necessary configuration information to support this service is also provided.
Generalized theory of the photoacoustic effect in a multilayer material (1999)

In this work, a generalized expression of the photoacoustic (PA) effect in a multilayer material is derived. This expression takes thermal and optical properties and geometry of a multilayer structure, as well as the thermal contact resistances between layers into consideration. In addition, a composite piston model consisting of a thermal piston and a mechanical piston of the PA effect is developed and interpreted from the viewpoint of thermodynamics. Mistakes occurring in the thermal piston model and in the composite piston model developed before are pointed out and corrected. It is also shown that the PA effect has an isochoric character for the thermal piston and a polytropic character with a polytropic factor of (2−1/γ) for the mechanical piston. The theory developed in this work is in good agreement with the experimental results, and is applicable to a wide range of photoacoustic problems.
Analysis of nonlinear electromagnetic metamaterials (2010)

We analyze the properties of a nonlinear metamaterial formed by integrating nonlinear components or materials into the capacitive regions of metamaterial elements. A straightforward homogenization procedure leads to general expressions for the nonlinear susceptibilities of the composite metamaterial medium. The expressions are convenient, as they enable inhomogeneous system of scattering elements to be described as a continuous medium using the standard notation of nonlinear optics. We illustrate the validity and accuracy of our theoretical framework by performing measurements on a fabricated metamaterial sample composed of an array of split ring resonators (SRRs) with packaged varactors embedded in the capacitive gaps in a manner similar to that of Wang et al. [Opt. Express 16, 16058 (2008)]. Because the SRRs exhibit a predominant magnetic response to electromagnetic fields, the varactor-loaded SRR composite can be described as a magnetic material with nonlinear terms in its effective magnetic susceptibility. Treating the composite as a nonlinear effective medium, we can quantitatively assess the performance of the medium to enhance and facilitate nonlinear processes, including second harmonic generation, three- and four-wave mixing, self-focusing and other well-known nonlinear phenomena. We illustrate the accuracy of our approach by predicting the intensity-dependent resonance frequency shift in the effective permeability of the varactor-loaded SRR medium and comparing with experimental measurements.
van der Waals interaction in nanotube bundles: Consequences on vibrational modes (1999)

We have developed a pair-potential approach for the evaluation of van der Waals interaction between carbon nanotubes in bundles. Starting from a continuum model, we show that the intertube modes range from 5 ${\mathrm{cm}}^{\ensuremath{-}1}$ to 60 ${\mathrm{cm}}^{\ensuremath{-}1}.$ Using a nonorthogonal tight-binding approximation for describing the covalent intratube bonding in addition, we confirm a slight chiral dependence of the breathing mode frequency and we found that this breathing mode frequency increases by $\ensuremath{\sim}10%$ if the nanotube lies inside a bundle as compared to inside the isolated tube.
Expression of HNF4α variants in pancreatic islets and Ins‐1 β cells (2008)

This is the first report of HNF4alpha9 expression in any tissue. Our findings extend our understanding of HNF4alpha gene transcription and function. This knowledge may be useful in efforts to recover or establish regulated insulin secretion.
Exploring the Association between Monoclonal Antibodies and Depression and Suicidal Ideation and Behavior: A VigiBase Study (2019)

Depression and suicidal ideation and behavior are seen in patients using mAbs, particularly mAbs used for treating autoimmune diseases that suppress the immune system. For interpretation of these data, the indications for use and other characteristics require further consideration.
Detecting and recognizing tables in spreadsheets (2010)

Detecting tables in a spreadsheet is the first step needed to make spreadsheet documents accessible to individuals with visual disabilities. Techniques to enable aural presentation and navigation of tables have been proposed, but they assume a thorough knowledge of the structure of the table; on the other hand, boundaries and structure of tables in a spreadsheet are not evident without a visual exploration. This paper presents an algorithm for table recognition in spreadsheets. The algorithm uses three types of cells as its basis: title cell, header cell, and data cell. Different attributes of the cells are used to identify the cell type within a spreadsheet. Hierarchical clustering is used to aggregate cells to compose the functional components of a table. The algorithm has been evaluated on a diverse set of benchmarks with very encouraging results.
Activity of the multikinase inhibitor dasatinib against ovarian cancer cells (2009)

These data provide a clear biological rationale to test dasatinib as a single agent or in combination with chemotherapy in patients with ovarian cancer.
Face-to-Face (1994)

The Educational and Research Foundation of the American Academy of Facial Plastic and Reconstructive Surgery (AAFPRS) was created in 1974 as a vehicle to address the medical, educational, and scientific issues and challenges facing facial plastic surgeons. Pro bono activities have always been an important part of the mission of AAFPRS. Over the last 2 years, an effort has been made to increase the emphasis on these programs and to provide more opportunities for facial plastic surgeons to contribute their skills to the less advantaged. The various pro bono activities already in existence were consolidated, and new opportunities for service were sought under a new program, "Face-to-Face." The purpose of the Face-to-Face program is to provide education and humanitarian medical care in facial plastic and reconstructive surgery to aid disadvantaged patients with facial deformities throughout the world. An advisory board consisting of the vice president for education and the chairs
Temperature elevation in tissues generated by finite-amplitude tone bursts of ultrasound (1990)

The temperature elevation in tissues generated by an ultrasonic beam of plane sawtooth wave tone bursts along its axis is calculated based on a solution of an extended Burgers’ equation for a medium with loss due to various relaxation processes. The absorption coefficient of the medium is assumed to be proportional to frequency to the bth power (1≤b≤1.4). The results show that when the power generated by a transducer is kept constant, an enhancement of temperature rise in the medium due to narrow- and high-amplitude bursts of ultrasound is evident. For example, if spatial-peak temporal-average intensity, ISPTA=0.1 W/cm2=const, the temperature rise generated by sawtooth wave tone bursts with a duty factor of 10−4 (ISPPA=1000 W/cm2 at the low-loss fluid and tissue interface where the sawtooth wave just forms) is about twice that generated by its corresponding linear continuous wave counterpart.
Microcatheter Intrathecal Urokinase Infusion Into Cisterna Magna for Prevention of Cerebral Vasospasm (2000)

In patients with recently ruptured aneurysms, GDC placement followed by immediate intrathecal administration of UK from the cisterna magna may be a safe and reasonable means of preventing vasospasms and may result in improved treatment outcomes.
Molecular cloning and characterization of a novel member of the UDP‐GalNAc:polypeptide <i>N</i>‐acetylgalactosaminyltransferase family, pp‐GalNAc‐T12<sup>1</sup> (2002)

We cloned in silico a novel human UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase (pp-GalNAc-T), pp-GalNAc-T12. The deduced amino acid sequence of pp-GalNAc-T12 contains all conserved motifs in pp-GalNAc-T family proteins. Quantitative real time polymerase chain reaction analysis revealed that the pp-GalNAc-T12 transcript was expressed mainly in digestive organs such as stomach, small intestine and colon. The recombinant pp-GalNAc-T12 transferred GalNAc to the mucin-derived peptides such as the Muc1a, Muc5AC, EA2 peptides and the GalNAc-Muc5AC glycopeptide. Since mucins are glycoproteins mainly produced in the digestive organs, our results suggest that pp-GalNAc-T12 plays an important role in the initial step of mucin-type oligosaccharide biosynthesis in digestive organs.
Integrated Ion Exchange and Liquid-Liquid Extraction Process for the Separation of Platinum Group Metals (PGM) (1982)

Abstract A process for concentration and separation of platinum group metals (PGM) by a combination of ion exchange and liquid-liquid extraction is presented. First the PGM metals are dissolved by HC1/C11 and then passed through an isothiouronium anion exchange resin, where specific absorption occurs. The thiourea eluate from the resin is converted to the chloride complexes. Further hydrolysis (conditioning) yields an aqueous feed to a liquid-liquid extraction step, with Alamine-336. Platinum and palladium are very well extracted, while most of the other PGM are rejected in the aqueous phase. The liquid-liquid extraction can be used by itself, if the level of the base metals does not exceed the concentration of the PGM ions. Platinum and palladium are now separated from each other by the selective stripping of palladium with thiourea, and platinum with thiocyanate. The paper discusses the extraction chemistry of all the steps, and provides also experimental pilot-plant results.
Anti–CTLA-4 Immunotherapy Does Not Deplete FOXP3+ Regulatory T Cells (Tregs) in Human Cancers—Letter (2018)

We read with great interest the work from Sharma and colleagues concluding that anti–CTLA-4 (αCTLA-4) therapy does not deplete intratumoral FOXP3+ Tregs in bladder, prostate, and melanoma human cancers ([1][1]). We believe this conclusion is supported by the data presented by the authors but
Current-voltage relation for superconducting d-wave junctions (1997)

We calculate the current-voltage (I-V) relation for planar superconducting d-wave junctions for both arbitrary transmission of the junction and arbitrary orientation of the d-wave superconductors. The midgap states (MGS) present at interfaces/surfaces of a d-wave superconductor influence the I-V relation. In some arrangements we find considerable negative differential conductance and lower threshold voltage for nonzero current due to resonant conduction through MGS.
Instability‐Assisted Direct Writing of Microstructured Fibers Featuring Sacrificial Bonds (2015)

A 30 μm-diameter thread of poly(lactic acid) (PLA) dissolved in dichloromethane is deposited on top of the eye of a sewing needle. The deposition robot traces a straight line; the helical shape of the thread is due to the liquid rope coiling instability. This instability is used to fabricate microstructured fibers with tailored mechanical properties.
Localization of a 34-amino-acid segment implicated in dimerization of the herpes simplex virus type 1 ICP4 polypeptide by a dimerization trap (1994)

The herpes simplex virus type 1 immediate-early protein ICP4 plays an essential role in the regulation of the expression of all viral genes. It is the major trans activator of early and late genes and also has a negative regulatory effect on immediate-early gene transcription. ICP4 is a sequence-specific DNA-binding protein and has always been purified in a dimeric form. The part of the protein that consists of the entire highly conserved region 2 and of the distal portion of region 1 retains the ability to specifically associate with DNA and to form homodimers in solution. In an attempt to map the dimerization domain of ICP4, we used a dimerization trap assay, in which we screened deletion fragments of this 217-amino-acid stretch for sequences that could confer dimerization properties on a heterologous cellular transcription factor (LFB1), which binds to its cognate DNA sequence only as a dimer. The analysis of these chimeric proteins expressed in vitro ultimately identified a stretch of 34 amino acids (343 to 376) that could still confer DNA-binding activity on the LFB1 reporter protein and thus apparently contained the ICP4 dimerization motif. Consistent with this result, a truncated ICP4 protein containing amino acids 343 to 490, in spite of the complete loss of DNA-binding activity, appeared to retain the capacity to form a heterodimer with a longer ICP4 peptide after coexpression in an in vitro translation system.
Quad Layout Embedding via Aligned Parameterization (2014)

Abstract Quad layouting, i.e. the partitioning of a surface into a coarse network of quadrilateral patches, is a fundamental step in application scenarios ranging from animation and simulation to reverse engineering and meshing. This process involves determining the layout's combinatorial structure as well as its geometric embedding in the surface. We present a novel quad layout algorithm that focuses on the embedding optimization, thereby complementing recent methods focusing on the structure optimization aspect. It takes as input a description of the target layout structure and computes a complete embedding in form of a parameterization globally optimized for isometry and, in particular, principal direction alignment. Besides being suited for fully automatic workflows, our method can also incorporate user constraints and support the tedious but common procedure of manual layouting .
Enhanced Outcoupling in Organic Light-Emitting Diodes via a High-Index Contrast Scattering Layer (2015)

Despite high internal quantum efficiencies, planar organic light-emitting diodes (OLEDs) typically suffer from limited outcoupling efficiencies. To improve this outcoupling efficiency, we have developed a new thin (∼2 μm) light scattering layer that employs air voids (low-index scattering centers) embedded in a high-index polyimide matrix to effectively frustrate the substrate-trapped light, increasing the outcoupling efficiency. The porous polyimide scattering layers are created through the simple and scalable fabrication technique of phase inversion. The optical properties of the scattering layers have been characterized via microscopy, transmittance/haze measurements, and ellipsometry, which demonstrate the excellent scattering properties of these layers. We have integrated these films into a green OLED stack, where they show a 65% enhancement of the external quantum efficiency and a 77% enhancement of the power efficiency. Furthermore, we have integrated these layers into a white OLED and observed similar enhancements. Both the green and white OLEDs additionally demonstrate excellent color stability over wide viewing angles with the integration of this thin scattering layer.
Physical hydrogels of associative star polymers (1993)

Amphiphilic star polymers consisting of a hydrophobic core and hydrophilic arms end-capped with hydrophobic moieties exhibit associative properties in aqueous solution. Using large hydrophobic aliphatic tri- or tetraisocyanates derived from m-TMI, a series of well-defined stars with three or four polyethylene oxide arms and nonylphenoxy end groups were synthesized and characterized. When dissolved in water, separation into a dilute and concentrated phase occurs. The polymer concentration remains constant in each phase, their volume fractions being proportional to the total polymer concentration. The gel phase resembles an amphiphilic hydrogel with a strong affinity for hydrophobic compounds. Brookfield viscosity measurements also confirm the associative properties of the star polymers.
Identification of Potent and Selective RNA Antagonists of the IFN-γ-Inducible CXCL10 Chemokine (2005)

CXCL10 (also known as IP-10 in humans and CRG-2 in mice) is a nonglycosylated chemokine and a member of the non-ELR CXC chemokine subfamily implicated in a variety of inflammatory conditions. The role of CXCL10 in different disease states still requires clarification, and new approaches are necessary to better understand its biological function. We report here the isolation of a series of nuclease-resistant RNA aptamers that act to antagonize human CXCL10 function in a number of in vitro and cell-based assays. The two most potent aptamers identified were highly selective for human CXCL10. A further aptamer was identified that antagonized both the human and the mouse CXCL10. A combination of a molecular-biology-based truncation and solid-phase synthesis enabled the truncation of one of the aptamers from 71 to 34 nucleotides. This was followed by PEGylation, 3' capping, and further stabilization of the RNA aptamer, while its high potency was maintained. These aptamers could be utilized as powerful target validation tools and may also have therapeutic potential. To our knowledge, the CXCL10 aptamers generated are the most potent antagonists of CXCL10/CXCR3 signaling reported to date.
Distribution of apolipoprotein A-IV in human plasma. (1985)

Human apoA-IV was purified from delipidated urinary chylomicrons. Monospecific antibodies were raised in rabbits and used to develop a double antibody radioimmunoassay (RIA). Displacement of 125I-labeled apoA-IV by plasma or purified chylomicron apoA-IV resulted in parallel displacement curves, indicating that apoA-IV from both sources share common antigenic determinants. The apoA-IV level in plasma from normal healthy fasting male subjects (n = 5) was 37.4 +/- 4.0 mg/dl, while fat-feeding increased the level to 49.1 +/- 7.9 mg/dl (P less than 0.05) at 4 hr. The apoA-IV level in plasma from abetalipoproteinemic fasting subjects was 13.7 +/- 3.1 mg/dl (n = 5). Plasma from a single fasting Tangier subject showed a reduced apoA-IV level of 21.1 mg/dl. The distribution of apoA-IV in fasting and postprandial plasma was determined by 6% agarose gel chromatography. Fifteen to 25% of plasma apoA-IV eluted in the region of plasma high density lipoprotein (HDL), with the remainder eluting in subsequent column fractions. In abetalipoproteinemic plasma this HDL fraction is reduced and lacks apoA-IV, suggesting that at least some of the apoA-IV on these particles is normally derived from triglyceride-rich lipoproteins. Lipemic plasma from a fat-fed subject showed a small rise (3%) in chylomicron-associated apoA-IV. Gel-filtered HDL and subsequent apoA-IV-containing fractions were subjected to 4-30% polyacrylamide gradient gel electrophoresis (4/30 GGE), and apoA-IV was identified by immunolocalization following transfer of proteins to nitrocellulose paper. In normal plasma apoA-IV was localized throughout all HDL fractions. In addition, normal plasma contained apoA-IV localized in a small particle (diameter 7.8-8.0 nm). This particle also contained apoA-I and lipid. A markedly elevated saturated to unsaturated cholesteryl ester ratio was present in gel-filtered plasma fractions containing small HDL, suggesting an intracellular origin of these particles. In abetalipoproteinemic plasma apoA-IV was absent from all HDL fractions except for the small HDL particles, suggesting that they are not derived from the surface of triglyceride-rich particles. All plasmas contained free apoA-IV. In contrast to gel-filtered plasma, lipoprotein subfractions of fasted normal plasma prepared in the ultracentrifuge primarily contained apoA-IV in the d greater than 1.26 g/ml fraction, suggesting an artifactual redistribution of the apolipoprotein during centrifugation. Overall, these data suggest that apoA-IV secretion into plasma is increased with fat feeding, and that apoA-IV normally exists as both a free apolipoprotein and in association with HDL particles.