gebhart/patrepeval huggingface dataset:
An impact sensing platform for spinal cord injury experiments (2013)

Real-time measurement of rat/guinea pig spinal cord mechanics during ex vivo experiments remains a nontrivial task due to the small size of the cord and the short impulse duration. To address this issue, we present an inexpensive strain measurement platform. It consists of an array of flexible, Parylene-C-passivated, pointed cantilevers of polyvinyl fluoride (PVDF) that penetrate the wall of an acrylic chamber. When a spinal cord is placed in the chamber and stimulated mechanically, its vibrations translate onto the PVDF cantilevers which in turn generate an electrical signal for recording. Vibrometer experiments of the cantilever reveal a deflection of up to 58 nm at its resonant frequency (~50 kHz). Voltage from a cantilever in a cord phantom has been recorded at two distances from the point of impact, showing 37 mV at 5 mm and 21 mV at 20 mm for a 40 kPa impact pressure.
Deoxygenation of sulfoxides promoted by electrophilic silicon reagents: preparation of aryl-substituted sulfonium salts (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDeoxygenation of sulfoxides promoted by electrophilic silicon reagents: preparation of aryl-substituted sulfonium saltsR. D. Miller, A. F. Renaldo, and H. ItoCite this: J. Org. Chem. 1988, 53, 23, 5571–5573Publication Date (Print):November 1, 1988Publication History Published online1 May 2002Published inissue 1 November 1988https://pubs.acs.org/doi/10.1021/jo00258a041https://doi.org/10.1021/jo00258a041research-articleACS PublicationsRequest reuse permissionsArticle Views1002Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Self-Localization of Mobile Robots Based on Visual Information (2006)

A CCD camera, a stepping motor and three artificial landmarks are used for localization of a mobile robot. The CCD camera is mounted on the robot and its rotation is controlled by the stepping motor. Then from the images captured by the CCD camera, image-processing techniques are used to determine the distances between the CCD camera and the three landmarks. On the basis of these distances, one can prove that the position of the robot can be determined uniquely provided that the three artificial landmarks observed are not installed in a line. Moreover, the heading angle of the robot can be determined from the rotation angle of the stepping motor. To account for possible installation errors, a nonlinear programming method is proposed. Meanwhile, a least-squares method is also be used to increase the accuracy of localization. To show the feasibility of the proposed method, an experimental example is given for illustration
Enantioselective Total Synthesis of Pladienolide B: A Potent Spliceosome Inhibitor (2012)

An enantioselective and convergent total synthesis of pladienolide B (1) is described. Pladienolide B binds to the SF3b complex of a spliceosome and inhibits mRNA splicing activity. The synthesis features an epoxide opening reaction, an asymmetric reduction of a β-keto ester, and a cross metathesis strategy for the side chain synthesis.
A minor form of starch branching enzyme in potato ( Solanum tuberosum L.) tubers has a major effect on starch structure: cloning and characterisation of multiple forms of SBE A (1999)

Full length cDNAs encoding a second starch branching enzyme (SBE A) isoform have been isolated from potato tubers. The predicted protein has a molecular mass of 101 kDa including a transit peptide of 48 amino acids. Multiple forms of the SBE A gene exist which differ mainly in the length of a polyglutamic acid repeat at the C-terminus of the protein. Expression of the mature protein in Escherichia coli demonstrates that the gene encodes an active SBE. Northern analysis demonstrates that SBE A mRNA is expressed at very low levels in tubers but is the predominant isoform in leaves. This expression pattern was confirmed by Western analysis using isoform specific polyclonal antibodies raised against E. coli expressed SBE A. SBE A protein is found predominantly in the soluble phase of tuber extracts, indicating a stromal location within the plastid. Transgenic potato plants expressing an antisense SBE A RNA were generated in which almost complete reductions in SBE A were observed. SBE activity in the leaves of these plants was severely reduced, but tuber activity was largely unaffected. Even so, the composition and structure of tuber starch from these plants was greatly altered. The proportion of linear chains was not significantly increased but the average chain length of amylopectin was greater, resulting in an increase in apparent amylose content as judged by iodine binding. In addition, the starch had much higher levels of phosphorous.
An insight into Finnish sport education and research in sport sciences (2016)

Education system in Finland. The main objective is to offer all citizens equal opportunities to receive education. The school themselves draw up their own curricula within the framework of the national core curriculum. There are no tuition fees at any level of education. Comprehensive schools provide free school lunches and materials.
Automated distributed system testing (1999)

Article Automated distributed system testing: designing an RTI verification system Share on Authors: John Tufarolo The MITRE Corporation, 1820 Dolley Madison Boulevard, McLean, VA The MITRE Corporation, 1820 Dolley Madison Boulevard, McLean, VAView Profile , Jeff Nielsen The MITRE Corporation, 1820 Dolley Madison Boulevard, McLean, VA The MITRE Corporation, 1820 Dolley Madison Boulevard, McLean, VAView Profile , Susan Symington The MITRE Corporaton, 1820 Dolley Madison Boulevard, McLean, VA The MITRE Corporaton, 1820 Dolley Madison Boulevard, McLean, VAView Profile , Richard Weatherly The MITRE Corporation, 1820 Dolley Madison Boulevard, McLean, VA The MITRE Corporation, 1820 Dolley Madison Boulevard, McLean, VAView Profile , Annette Wilson The MITRE Corporation, 1820 Dolley Madison Boulevard, McLean, VA The MITRE Corporation, 1820 Dolley Madison Boulevard, McLean, VAView Profile , Timothy C. Hyon TRW International Defense, Simulation Systems, 12902 Federal Systems Park Drive, Fairfax, VA TRW International Defense, Simulation Systems, 12902 Federal Systems Park Drive, Fairfax, VAView Profile Authors Info & Claims WSC '99: Proceedings of the 31st conference on Winter simulation: Simulation---a bridge to the future - Volume 2December 1999 Pages 1094–1102https://doi.org/10.1145/324898.325003Online:01 December 1999Publication History 3citation482DownloadsMetricsTotal Citations3Total Downloads482Last 12 Months1Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
The Retroviral Hypermutation Specificity of APOBEC3F and APOBEC3G Is Governed by the C-terminal DNA Cytosine Deaminase Domain (2005)

The human proteins APOBEC3F and APOBEC3G restrict retroviral infection by deaminating cytosine residues in the first cDNA strand of a replicating virus. These proteins have two putative deaminase domains, and it is unclear whether one or both catalyze deamination, unlike their homologs, AID and APOBEC1, which are well characterized single domain deaminases. Here, we show that only the C-terminal cytosine deaminase domain of APOBEC3F and -3G governs retroviral hypermutation. A chimeric protein with the N-terminal cytosine deaminase domain from APOBEC3G and the C-terminal cytosine deaminase domain from APOBEC3F elicited a dinucleotide hypermutation preference nearly indistinguishable from that of APOBEC3F. This 5'-TC-->TT mutational specificity was confirmed in a heterologous Escherichia coli-based mutation assay, in which the 5'-CC-->CT dinucleotide hypermutation preference of APOBEC3G also mapped to the C-terminal deaminase domain. An N-terminal APOBEC3G deletion mutant displayed a preference indistinguishable from that of the full-length protein, and replacing the C-terminal deaminase domain of APOBEC3F with AID resulted in an AID-like mutational signature. Together, these data indicate that only the C-terminal domain of APOBEC3F and -3G dictates the retroviral minus strand 5'-TC and 5'-CC dinucleotide hypermutation preferences, respectively, leaving the N-terminal domain to perform other aspects of retroviral restriction.
Rural Industrialization and Population Change (1973)

Amongst the many problems economic historians have been studying recently in the context of industrialization, the interaction of rural industrialization and population change in a period preceding and accompanying the Industrial Revolution proper is one of the most exciting and promising ones. It is exciting because it enables us to shed light on one of the crucial questions in the whole complex of industrialization: why did some regions industrialize early and successfully and others did not? It is promising because here is a field where the employment of new methods and assiduous labor can lead to fairly exact results. Perhaps this is a point where finally a breakthrough may be accomplished which cuts the vicious circle in which much of the debate about the role of population change in the Industrial Revolution was caught for so long. Was it a precondition or a consequence, or both, and if either, in what respect?
Binary Complex Electrolytes Based on LiX[X=N(SO[sub 2]CF[sub 3])[sub 2][sup −], CF[sub 3]SO[sub 3][sup −], ClO[sub 4][sup −]]-Acetamide for Electric Double Layer Capacitors (2007)

Binary complex systems have been prepared based on acetamide with lithium bis(trifluoromethane sulfone)imide [, ], lithium triflate , and lithium perchlorate , respectively. Due to their superior physicochemical properties, such as wide liquid-phase range and high ionic conductivity, they can be practically useful electrolytes for electrochemical capacitors. We prepared electric double-layer capacitors (EDLCs) composed of activated carbon electrode and the above three complex systems based on acetamide as the electrolytes and evaluated the electrochemical performances of the EDLCs with cyclic voltammetry (CV), ac impedance spectroscopy, and galvanostatic charge/discharge, etc. The EDLCs with these components show better electrochemical properties in specific capacitance and cycling performances at ambient and elevated temperatures. Considering that the complex electrolytes possess a number of excellent properties such as negligible vapor pressure and high thermal stability, the results demonstrate that these electrolytes are promising electrolyte candidates for the EDLCs and especially for those requiring high safety and stability.
An approach to base placement for effective collaboration of multiple autonomous industrial robots (2015)

There are many benefits for the deployment of multiple autonomous industrial robots to carry out a task, particularly if the robots act in a highly collaborative manner. Collaboration can be possible when each robot is able to autonomously explore the environment, localize itself, create a map of the environment and communicate with other robots. This paper presents an approach to the modeling of the collaboration problem of multiple robots determining optimal base positions and orientations in an environment by considering the team objectives and the information shared amongst the robots. It is assumed that the robots can communicate so as to share information on the environment, their operation status and their capabilities. The approach has been applied to a team of robots that are required to perform complete surface coverage tasks such as grit-blasting and spray painting in unstructured environments. Case studies of such applications are presented to demonstrate the effectiveness of the approach.
The Crystal Structure of DJ-1, a Protein Related to Male Fertility and Parkinson's Disease (2003)

DJ-1 is a multifunctional protein that plays essential roles in tissues with higher order biological functions such as the testis and brain. DJ-1 is related to male fertility, and its level in sperm decreases in response to exposure to sperm toxicants. DJ-1 has also been identified as a hydroperoxide-responsive protein. Recently, a mutation of DJ-1 was found to be responsible for familial Parkinson's disease. Here, we present the crystal structure of DJ-1 refined to 1.95-A resolution. DJ-1 forms a dimer in the crystal, and the monomer takes a flavodoxin-like Rossmann-fold. DJ-1 is structurally most similar to the monomer subunit of protease I, the intracellular cysteine protease from Pyrococcus horikoshii, and belongs to the Class I glutamine amidotransferase-like superfamily. However, DJ-1 contains an additional alpha-helix at the C-terminal region, which blocks the putative catalytic site of DJ-1 and appears to regulate the enzymatic activity. DJ-1 may induce conformational changes to acquire catalytic activity in response to oxidative stress.
Distribution and dissipation of metolachlor in soil columns (1993)

Une expérience est menée au laboratoire sur des échantillons de sols de Montpellier. les demi-vies du métolachlor varient de 31 à 54 jours en fonction de la dose d'application. Le taux de migration de l'herbicide est étudié ainsi que l'adsorption et la désorption, à plusieurs profondeurs
Second-look ultrasonography for MRI-detected suspicious breast lesions in patients with breast cancer (2014)

We have concluded that second-look US is a useful diagnostic tool for lesions incidentally detected on breast MRI, as in this study, it could identify 86.8% of the MRI-detected breast lesions.
Hyperferritinemia, iron overload, and multiple metabolic alterations identify patients at risk for nonalcoholic steatohepatitis (2001)

The aim of this study was to define in patients with hyperferritinemia and normal transferrin saturation the relationships among hyperferritinemia, iron overload, HFE gene mutations, the presence of metabolic alterations, and nonalcoholic steatohepatitis (NASH).Forty patients with increased serum ferritin, resistant to dietary restriction and normal transferrin saturation, 90 with ultrasonographic evidence of hepatic steatosis, and 60 obligate heterozygotes for hemochromatosis, all negative for alcohol abuse, hepatitis virus infections, and inflammation were studied. Transferrin saturation, serum ferritin, uric acid, lipids, glucose tolerance, insulin resistance, HFE gene mutations, liver histology, and hepatic iron concentration were analyzed.Of the 40 patients with hyperferritinemia, 29 (72%) had biochemical metabolic abnormalities, 18 of the 26 examined (69%) had insulin resistance, 26 (65%) had the presence of one of the two HFE gene mutations (normal controls, 33 of 128 [26%], p < 0.0001), and all had increased liver iron concentration. Thirty-one patients (77%) had histology compatible with NASH. At univariate analysis, NASH was significantly associated with the presence of metabolic alterations, the C282Y mutation, and severity of fibrosis. At multivariate analysis, NASH was associated with the coexistence of multiple metabolic alterations (odds ratio = 5.2, 95% CI = 0.95-28.7). The risk of having NASH augmented in the presence of higher values of ferritin and liver iron concentration. Among the 90 patients with ultrasonographic evidence of hepatic steatosis, 24 (27%) had increased serum ferritin with normal transferrin saturation, but only six remained hyperferritinemic after dietary restriction.Increased ferritin with normal transferrin saturation is frequently found in patients with hepatic steatosis, but it reflects iron overload only in those patients in whom it persists despite an appropriate diet. The simultaneous disorder of iron and glucose and/or lipid metabolism, in most of the cases associated with insulin resistance, is responsible for persistent hyperferritinemia and identifies patients at risk for NASH.
Initial reactions at the interface of Pt and amorphous silicon (1983)

The initial reactions at the interface of Pt on a-Si:H are probed by interference enhanced Raman scattering, TEM, and Auger, and the atomic structural changes are correlated with electrical properties determined from current–voltage and internal photoemission measurements. It is shown that a disordered Pt–Si intermixed phase of less than 20 Å thick exists at the interface immediately after deposition, and this phase grows thicker with annealing to 150 °C. Annealing at 200 °C causes the nucleation of crystalline silicide phases. The Schottky diodes exhibit rectification over greater than ten orders of magnitude of current density. Initially, the as-deposited diodes exhibit an ideality parameter of ∼1.11. Subsequently, the value drops to 1.04 as the silicide develops. Internal photoemission results indicate deviations from expected behavior.
Experimental Investigation of Thermochemically-Derived Fuels in a Diesel Engine (2018)

This thesis is a comparative study on thermochemical conversion of biomass and waste feedstocks into fuels and is divided into two streams. The first investigates the use of wet microalgae feedstocks, using hydrothermal liquefaction (HTL), to produce biocrude. The second stream explores the use of dry waste tyre feedstocks using Green Distillation Technology (GDT), a modified pyrolysis process, to make tyre oil. An experimental investigation of the physicochemical properties of biocrude oil and tyre oil is made. Finally, the impact of the both fuels on a diesel engine was investigated.
Monocyte Fc γ receptor cross-linking induces IL-8 production (1995)

In response to bacterial cell wall products such as LPS, monocytes produce IL-8, a powerful neutrophil chemotaxin. However, in the absence of bacterial pathogens, immune complex-mediated diseases such as rheumatoid arthritis are associated with high levels of IL-8 in monocyte-rich compartments. Since it is known that IgG-containing immune complexes can recruit neutrophils via an Fc gamma R-dependent process, we hypothesized that cross-linking of monocyte Fc gamma receptors may induce IL-8. To test this hypothesis, peripheral blood mononuclear cells were evaluated for IL-8 induction in response to immobilized LPS-free pooled human IgG. Immobilized IgG, but not soluble IgG, induced IL-8 in a dose-dependent manner (p < 0.05, r = 0.99). This induction corresponded with an up-regulation in IL-8 steady state mRNA levels that peaked at 4 h. The released IL-8 was functional, since supernatants induced concentration-dependent neutrophil migration that was inhibited by a monoclonal anti-IL-8 Ab. Evaluation of purified monocytes for IL-8 production, as well as FACS analysis of IgG-stimulated PBMC preparations, demonstrated that monocytes are the principal IL-8 producer cell. Thus, monocyte Fc gamma R cross-linking induces biologically active IL-8, which may participate in the pathogenesis of immune complex-mediated diseases.
A Systematic Review of the Effects of Resident Duty Hour Restrictions in Surgery (2014)

Recent RDH changes are not consistently associated with improvements in resident well-being, and have negative impacts on patient outcomes and performance on certification examinations. Greater flexibility to accommodate resident training needs is required. Further erosion of training time should be considered with great caution.
Threshold lowering in GaN micropillar lasers by means of spatially selective optical pumping (2001)

A new optical pumping method is demonstrated for creating a population inversion in GaN micropillar cavities with circular symmetry. This approach employs an axicon lens to produce a ring-shaped optical beam and provides for independent control of ring thickness and diameter. By bringing the pump beam into coincidence with whispering gallery modes confined near the outer rim of the cavity, we achieve a significant reduction in the threshold pump intensity for room-temperature operation of GaN micropillar lasers.
Magnetic Guidance of Autonomous Vehicles (1986)

Increasing interest in underwater autonomous vehicles has resulted in a search for suitable guidance systems. Magnetic techniques could provide supplementary guidance for autonomous vehicles that need occasional precise position fixes to update their standard navigational systems, or that want to return to a particular spot on the ocean bottom with great accuracy. A small permanent magnet resting at a precisely known spot on the ocean's bottom or naturally occurring key features in a magnetic survey of the bottom could provide the necessary magnetic signal. Of the several magnetic guidance approaches considered, an adaptive search technique seems the most promising. In adaptive search, the location of each successive search pass is determined by information gathered on the previous pass. Computer simulation results show that three search passes are usually sufficient to locate the center of the magnetic anomaly to within several feet. The favored sensor configuration is a scalar magnetometer whose outputs are successively subtracted along the path of sensor motion to form an approximation to the spatial gradient of the sensor's output. Data interpretation for this technique appears simple enough to be done automatically by either algorithmic or artificial intelligence techniques.
Ultra-large bandwidth hollow-core guiding in all-silica Bragg fibers with nano-supports (2004)

We demonstrate a new class of hollow-core Bragg fibers that are composed of concentric cylindrical silica rings separated by nanoscale support bridges. We theoretically predict and experimentally observe hollow-core confinement over an octave frequency range. The bandwidth of bandgap guiding in this new class of Bragg fibers exceeds that of other hollow-core fibers reported in the literature. With only three rings of silica cladding layers, these Bragg fibers achieve propagation loss of the order of 1 dB/m.