gebhart/patrepeval huggingface dataset:
Increasing quality of life by improving the quality of skin in patients with atopic dermatitis (2007)

Atopic dermatitis is a chronic relapsing inflammatory skin disease which usually starts during the first years of life. In patients with the disease, the quality of skin is severely affected, and this is closely linked to a reduced quality of life. An increasing prevalence of the disease has also been observed during recent years, which has been attributed to potential provocation factors in the environment. The environmental influence of the disease is complex, but the role of stratum corneum as a biosensor regulating the response to a variety of insults has been suggested as one crucial factor. Therefore, our daily hygiene and treatment of dryness are necessary measures to improve the quality of life and possibly reduce the frequency of the disease. Soaps as well as moisturizers show important differences in their impact on barrier function.
Analysis of cardiac function from MR images (1997)

Recent research and development in cardiac magnetic resonance imaging (MRI) has shown that a single exam, performed entirely in an MR scanner, might well replace the current sequence of tests for coronary disease. Though an MR scanner is expensive, the ability to consolidate diagnostic tests into a single session would significantly reduce costs and increase convenience for the patient. MRI might also provide the physician with diagnostic information on myocardial function that is not available from the standard battery of tests. In this article, we concentrate on one aspect of a cardiac MRI exam that provides previously unavailable information: assessment of myocardial contraction.
The role of mitosis in LDL transport through cultured endothelial cell monolayers (2010)

We (7) have previously shown that leaky junctions associated with dying or dividing cells are the dominant pathway for LDL transport under convective conditions, accounting for >90% of the transport. We (8) have also recently shown that the permeability of bovine aortic endothelial cell monolayers is highly correlated with their rate of apoptosis and that inhibiting apoptosis lowers the permeability of the monolayers to LDL. To explore the role of mitosis in the leaky junction pathway, the microtubule-stabilizing agent paclitaxel was used to alter the rate of mitosis, and LDL flux and water flux (J(v)) were measured. Control monolayers had an average mitosis rate of 0.029%. Treatment with paclitaxel (2.5 μM) for 1.5, 3, 4.5, or 6 h yielded increasing rates of mitosis ranging from 0.099% to 1.03%. The convective permeability of LDL (P(e)) increased up to fivefold, whereas J(v) increased up to threefold, over this range of mitosis rates. We found strong correlations between the mitosis rate and both P(e) and J(v). However, compared with our previous apoptosis study (8), we found that mitosis was only half as effective as apoptosis in increasing P(e). The results led us to conclude that while mitosis-related leaky junctions might play a role in the initial infiltration of LDL into the artery wall, the progression of atherosclerosis might be more closely correlated with apoptosis-related leaky junctions.
Frequency of bone marrow T cells responding to HLA-identical non-leukemic and leukemic stimulator cells. (1993)

Grafted immunocompetent cells are considered responsible for GVHD as well as for the elimination of residual leukemic cells ('graft-versus-leukemia reactivity', GVLR) in leukemic patients after allogeneic BMT. Clinical and experimental investigations have given contradictory answers to the question whether GVHD and GVLR are two manifestations of the same process or separate immunologic processes. We have addressed this question by analysing the primary in vitro response of BM-derived proliferating and cytotoxic T lymphocyte precursors (PTLp and CTLp) in HLA identical relative pairs (n = 17). PTLp frequency estimation reveals strong responses (> 1 in 5000) on non-leukemic as well as leukemic stimulation in a majority of cases. CTLp amount variably to 10-100% of the proliferating precursor cells. Preliminary specificity analyses show that on non-leukemic stimulation about 90% of colonies exhibit exclusive lysis of the non-leukemic target. At the same time, on leukemic stimulation, about 75% of cytolytic colonies are exclusively reactive against leukemic targets without crossreactivity against nonleukemic targets from the same patient. Our data show that primary in vitro responses in HLA identical sibling pairs may be as strong as those against allo MHC antigens. In addition CTL specifically lysing leukemic or non-leukemic targets may represent an in vitro model of the immunologic non-identity of GVHD and GVLR.
Anycast routing for mobile networking (2003)

This paper considers the problem of locating and forwarding network traffic to any one of a set of distributed servers or service points-primarily in the context of mobile ad hoc networks. The advantages of providing such a capability in mobile networks through the use of anycast routing techniques at the network layer are discussed. The results of a simulation study are highlighted to demonstrate how anycast routing techniques can provide a one-to any communication capability with greater efficiency than traditional unicast based techniques. The simulation results also indicate anycast routing simplifies required configuration and management and reduces connection setup latency and overall message packet delay. Potential applications of anycast routing technology in military networks are presented and related issues are discussed.
State Of Art Of Acrylate Resists: An Overview Of Polymer Structure And Lithographic Performance (1983)

The acrylate family of resists based on polymethyl methacrylate (PMMA) has paved the way for submicron lithography. The physical and chemical modifications, which have improved the performance of PMMA, are reviewed. These improvements include sensitivity to radiation (electron-beam, optical, ion, and x-ray), thermal and plasma process stability, and superior film quality. Structural modifications of the acrylate polymer chain have been the main contributors to enhanced lithographic performance.
[Investigations to gastric tolerance of a sustained release theophylline formulation (author's transl)]. (1982)

The measurement of the transmural gastric potential difference (PD) is a suitable method to quantify irritations of the human gastric mucosa caused by drugs. Purpose of this investigation was to check the gastric tolerance of Bronchoretard, a new developed "divided-dose" drug formulation of theophylline as retarded pellets in capsules in comparison to pure theophylline solution. After having checked the suitability of the procedure in respect of the obtained results, a study on 7 healthy male volunteers was considered to be justifiable, as the development of retarded theophylline preparations, which cause lower irritations in the stomach by slower release of pure theophylline, has a high therapeutic value. With the gastric PD model, developed at our institute following variables were calculated: the area under the baseline (AUB), the "Reizindex" (RI), the mean instability time (MIT) of the membrane and the maximum potential difference (Pdmax). The volunteers wee admitted to the ward of our institute 36 h before the first application. On 2 different days 350 mg theophylline, dissolved in 50 ml physiological saline as well as 1 capsule Bronchoretard containing 350 mg theophylline, were administered Cross over according to a randomisation plan and the deviation of the PD was measured as a function of time. The study led to the following results: after administration of Bronchoretard the AUB is statistically significant smaller than after administration of theophylline solution (P less than 0.05). After administration of Bronchoretard the RI is statistically significant smaller than after administration of theophylline solution (p less than 0.05). After administration of Bronchoretard the mean instability time is statistically significant smaller than after administration of theophylline solution (p less than 0.05). After administration of Bronchoretard Pdmax is smaller in trend than theophylline solution (p greater than 0.05). The oral administration of Bronchoretard leads to considerably lower irritation than the instillation of the same dose of theophylline in solution.
Massive bone allografts for limb salvage. (1997)

Massive bone allografts for limb salvage.S R Patel, P R Miller, M Gross and J RyanAudio Available | Share
Transmission electron microscopy characterization of electrically stressed AlGaN/GaN high electron mobility transistor devices (2012)

A set of AlGaN/GaN high electron mobility transistor devices has been investigated using step-stress testing, and representative samples of undegraded, source-side-degraded, and drain-side-degraded devices were examined using electron microscopy and microanalysis. An unstressed reference sample was also examined. All tested devices and their corresponding transmission electron microscopy samples originated from the same wafer and thus received nominally identical processing. Step-stressing was performed on each device and the corresponding current–voltage characteristics were generated. Degradation in electrical performance, specifically greatly increased gate leakage current, was shown to be correlated with the presence of crystal defects near the gate edges. However, the drain-side-degraded device showed a surface pit on the source side, and another region of the same device showed no evidence of damage. Moreover, significant metal diffusion into the barrier layer from the gate contacts was also observed, as well as thin amorphous oxide layers below the gate metal contacts, even in the unstressed sample. Overall, these observations emphasize that gate-edge defects provide only a partial explanation for device failure.
Monte Carlo particle simulation of GaAs submicron <i>n</i> <sup>+</sup> - <i>i</i> - <i>n</i> <sup>+</sup> diode (1982)

Monte Carlo particle simulation of a GaAs submicron n+-i-n+ diode showed that the electron transport in the diode is almost ballistic in nature, so long as the electron energy is below 0.36 eV. A maximum electron velocity of 1 × 108 cm s−1 was observed at certain conditions. Effects of the electron backscattering from the anode n+-layer are also discussed.
Periodic Trends from Metal Substitution in Bimetallic Mo-Based Phosphides for Hydrodeoxygenation and Hydrogenation Reactions (2018)

Bimetallic phosphides are promising materials for biomass valorization, yet many metal combinations are understudied as catalysts and require further analysis to realize their superior properties. Herein, we provide the synthesis, characterization, and catalytic performance of a variety of period 4 and 5 solid solutions of molybdenum-based bimetallic phosphides (MMoP, M = Fe, Co, Ni, Ru). From the results, the charge sharing between the metals and phosphorus control the relative oxidation of Mo and reduction of P in the lattice, which were both indirectly observed in binding energy shifts in X-ray photoelectron spectroscopy (XPS) and absorption energy shifts in X-ray absorption near-edge spectroscopy (XANES). For MMoP (M = Fe, Co, Ni), the more oxidized the Mo in the bimetallic phosphide, the higher the selectivity to benzene from phenol via direct deoxygenation at 400 °C and 750 psig. This phenomenon was observed in the bimetallic materials synthesized across period 4, where aromatic selectivity and degree of Mo oxidation both decreased in the following order FeMoP ≫ CoMoP > NiMoP. Alternatively, in the case of MMoP (M = Fe, Ru), the P in RuMoP is more oxidized compared to that in FeMoP, and the selectivity toward the hydrogenation pathway increased due to the interaction between the aromatic rings and the P species on the surface. For RuMoP and NiMoP, cyclohexanol was selectively produced from phenol with >99% selectivity when the reaction temperature was lowered to 125 °C at 750 psig, whereas FeMoP and CoMoP were not active under these conditions. Last, complete deoxygenation of phenol to benzene, cyclohexane, and cyclohexene was accomplished using mixtures of RuMoP and FeMoP in flow and batch experiments. These results highlight the versatility and wide applicability of transition metal phosphides for biomass conversions.
Adelantadas, virreinas y aventureras en los primeros años de la conquista de América (2002)

La ausencia del elemento femenino en el contexto general de la conquista de América obedece a la idea generalizada de brutalidad y pillaje que se ha querido atribuir al colonizador español. Sin embargo, como veremos en el presente estudio, la mujer española ocupó puestos mucho más importantes de lo que tradicionalmente se ha venido creyendo en la sociedad hispanoamericana.
Optimization Design Process of Diagrid Node for Tall buildings (2011)

The diagrid structure is now one of the trends in tall-building structures. It is preferred not only because of its distinctive appearance but also because of its structural advantages. There are few diagrid buildings that actually exist, however, because of the nodes, which are difficult to make and cost too much. In this study, a node-type diagrid building material with a more efficient structure but with fewer diagrid nodes, fabricated using the finite element method, was proposed and validated via experimentation.
Linear solvation energy relationships. 16. Dipole/dipole contributions to formation constants of some "hydrogen bonded complexes" (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLinear solvation energy relationships. 16. Dipole/dipole contributions to formation constants of some "hydrogen bonded complexes"Mortimer J. Kamlet, Charles Dickinson, Thor Gramstad, and R. W. TaftCite this: J. Org. Chem. 1982, 47, 25, 4971–4975Publication Date (Print):December 1, 1982Publication History Published online1 May 2002Published inissue 1 December 1982https://doi.org/10.1021/jo00146a028RIGHTS & PERMISSIONSArticle Views107Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (635 KB) Get e-Alertsclose Get e-Alerts
Separation of Oxygen from Air Using Coordination Complexes: A Review (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSeparation of Oxygen from Air Using Coordination Complexes: A ReviewGuang Qing Li and Rakesh GovindCite this: Ind. Eng. Chem. Res. 1994, 33, 4, 755–783Publication Date (Print):April 1, 1994Publication History Published online1 May 2002Published inissue 1 April 1994https://pubs.acs.org/doi/10.1021/ie00028a001https://doi.org/10.1021/ie00028a001research-articleACS PublicationsRequest reuse permissionsArticle Views992Altmetric-Citations60LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A GPS Carrier Phase Processor for Real-Time High Dynamics Tracking (1997)

error budgets on navigation. Validation is both challenging
and expensive. While existing carrier phase RTK truth
systems are capable of decimeter performance, they fail in
realistic high dynamics maneuvers with blockages. In order
to achieve robust carrier phase tracking aboard range test
pods and other vehicles, a powerful adaptive filter structure
was developed for enhancing phase tracking functions of
existing and future receivers. The technique optimally
processes raw correlator data obtained prior to receiver
tracking loops.
Test pod blockage and dynamics models were developed
and used to analyze reception profiles recorded in actual
aircraft flight tests. These profiles were used to drive a 200
Hz model of the GPS receiver’s correlator bank and IMU,
permitting closed loop simulation of the enhanced tracking
functions. Phase navigation simulations were carried out
with single and multiple antennas, with and without IMU, in
figure-8 dive, and aileron roll maneuvers, to 18 g’s. The
optimal combining of dual antennas mitigated satellite block-
ages. Stability of the tightly coupled GPS/IMU integration
was demonstrated.
Function, mechanism and regulation of cytochrome <i>P</i>-450 enzymes in plants (1992)

Conference Article| May 01 1992 Function, mechanism and regulation of cytochrome P-450 enzymes in plants Francis Durst; Francis Durst 1Institut de Biologie Moléculaire des Plantes — CNRS, Département d'Enzymologie Cellulaire et Moléculaire, 28, rue Goethe, F-67083 Strasbourg, France Search for other works by this author on: This Site PubMed Google Scholar Irène Benveniste; Irène Benveniste 1Institut de Biologie Moléculaire des Plantes — CNRS, Département d'Enzymologie Cellulaire et Moléculaire, 28, rue Goethe, F-67083 Strasbourg, France Search for other works by this author on: This Site PubMed Google Scholar Jean-Pierre Salaün; Jean-Pierre Salaün 1Institut de Biologie Moléculaire des Plantes — CNRS, Département d'Enzymologie Cellulaire et Moléculaire, 28, rue Goethe, F-67083 Strasbourg, France Search for other works by this author on: This Site PubMed Google Scholar Danièle Werck-Reichhart Danièle Werck-Reichhart 1Institut de Biologie Moléculaire des Plantes — CNRS, Département d'Enzymologie Cellulaire et Moléculaire, 28, rue Goethe, F-67083 Strasbourg, France Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1992) 20 (2): 353–357. https://doi.org/10.1042/bst0200353 Article history Received: December 18 1991 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation Francis Durst, Irène Benveniste, Jean-Pierre Salaün, Danièle Werck-Reichhart; Function, mechanism and regulation of cytochrome P-450 enzymes in plants. Biochem Soc Trans 1 May 1992; 20 (2): 353–357. doi: https://doi.org/10.1042/bst0200353 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: E.R., endoplasmic reticulum, LAH, lauric acid hydroxylase, CA4H, cinnamic acid 4-hydroxylase This content is only available as a PDF. © 1992 Biochemical Society1992 Article PDF first page preview Close Modal You do not currently have access to this content.
Novel and Emerging Treatments for Autism Spectrum Disorders: A Systematic Review (2009)

The reviewed treatments for ASD are commonly used, and some are supported by prospective RCTs. Promising treatments include melatonin, antioxidants, acetylcholinesterase inhibitors, naltrexone, and music therapy. All of the reviewed treatments are currently considered off-label for ASD (ie, not FDA-approved) and some have adverse effects. Further studies exploring these treatments are needed. Physicians treating children with an ASD should make it standard practice to inquire about each child's possible use of these types of treatments.
Targeting and Cellular Trafficking of Magnetic Nanoparticles for Prostate Cancer Imaging (2007)

Antibody-conjugated iron oxide nanoparticles offer a specific and sensitive tool to enhance magnetic resonance (MR) images of both local and metastatic cancer. Prostate-specific membrane antigen (PSMA) is predominantly expressed on the neovasculature of solid tumors and on the surface of prostate cells, with enhanced expression following androgen deprivation therapy. Biotinylated anti-PSMA antibody was conjugated to streptavidin-labeled iron oxide nanoparticles and used in MR imaging and confocal laser scanning microscopic imaging studies using LNCaP prostate cancer cells. Labeled iron oxide nanoparticles are internalized by receptor-mediated endocytosis, which involves the formation of clathrin-coated vesicles. Endocytosed particles are not targeted to the Golgi apparatus for recycling but instead accumulate within lysosomes. In T(1)-weighted MR images, the signal enhancement owing to the magnetic particles was greater for cells with magnetic particles bound to the cell surface than for cells that internalized the particles. However, the location of the particles (surface vs internal) did not significantly alter their effect on T(2)-weighted images. Our findings indicate that targeting prostate cancer cells using PSMA offers a specific and sensitive technique for enhancing MR images.
Abstract 714: Targeting Coagulation Factor XII to Protect from Cardiac Ischemia Reperfusion Injury (2007)

Formation of fibrin is critical for limiting blood loss at a site of blood vessel injury (hemostasis), but may also contribute to vascular thrombosis and thus exaggerate myocardial ischemia/reperfusion injury. Hereditary deficiency of factor XII (FXII), the protease that triggers the intrinsic pathway of coagulation in vitro, is not associated with spontaneous or excessive injury-related bleeding, but can reduce thrombus formation. Therefore, we studied the contribution of FXII for myocardial ischemia reperfusion injury. Following 30 minutes of ischemia and 24 hours of reperfusion infarct size in FXII deficient mice was significantly reduced as compared to wild type controls (infarct/area at risk, WT vs. FXII−/−, 73.5%±4.4% vs. 42.3±1.6%, p<0.001) despite similar area at risk (WT vs. FXII−/−, 28.3%±1.7% vs. 29.9±1.0%, p=n.s.). There was no difference in bleeding complications and bleeding time. Mice deficient in the FXII substrate factor XI were similarly protected from ischemia reperfusion injury (infarct/area at risk, FXI−/−, 16.9%±4.1%, vs. WT p<0.001). The phenotype of FXII−/−mice could be rescued by intravenous application of human FXII (infarct/area at risk, FXII−/−+FXII, 77.3%±8.4%, p<0.001 vs. FXIIKO). WT mice treated with the FXII inhibitor PCK (Pro-Phe-Arg-chloromethylketone) were similarly protected from myocardial ischemia/reperfusion injury (infarct/area at risk, 46.5% ±3.7%, vs. WT p<0.001). The data suggest that the intrinsic pathway is crucial for pathological clotting in myocardial ischemia reperfusion injury. FXII inhibition may offer a selective and safe strategy to reduce ischemic injury.