gebhart/patrepeval huggingface dataset:
Muscle and tendon morphogenesis in the avian hind limb (1998)

The proper development of the musculoskeletal system in the tetrapod limb requires the coordinated development of muscle, tendon and cartilage. This paper examines the morphogenesis of muscle and tendon in the developing avian hind limb. Based on a developmental series of embryos labeled with myosin and tenascin antibodies in whole mount, an integrative description of the temporal sequence and spatial pattern of muscle and tendon morphogenesis and their relationship to cartilage throughout the chick hind limb is presented for the first time. Anatomically distinct muscles arise by the progressive segregation of muscle: differentiated myotubes first appear as a pair of dorsal and ventral muscle masses; these masses subdivide into dorsal and ventral thigh, shank and foot muscle masses; and finally these six masses segregate into individual muscles. From their initial appearance, most myotubes are precisely oriented and their pattern presages the pattern of future, individual muscles. Anatomically distinct tendons emerge from three tendon primordia associated with the major joints of the limb. Contrary to previous reports, comparison of muscle and tendon reveals that much of their morphogenesis is temporally and spatially closely associated. To test whether reciprocal muscle-tendon interactions are necessary for correct muscle-tendon patterning or whether morphogenesis of each of these tissues is autonomous, two sets of experiments were conducted: (1) tendon development was examined in muscleless limbs produced by coelomic grafting of early limb buds and (2) muscle development was analyzed in limbs where tendon had been surgically altered. These experiments demonstrate that in the avian hind limb the initial morphogenetic events, formation of tendon primordia and initial differentiation of myogenic precursors, occur autonomously with respect to one another. However, later morphogenetic events, such as subdivision of muscle masses and segregation of tendon primordia into individual tendons, do require to various degrees reciprocal interactions between muscle and tendon. The dependence of these later morphogenetic events on tissue interactions differs between different proximodistal regions of the limb.
A Solanesyl-diphosphate Synthase Localizes in Glycosomes of Trypanosoma cruzi (2006)

We report the cloning of a Trypanosoma cruzi gene encoding a solanesyl-diphosphate synthase, TcSPPS. The amino acid sequence (molecular mass approximately 39 kDa) is homologous to polyprenyl-diphosphate synthases from different organisms, showing the seven conserved motifs and the typical hydrophobic profile. TcSPPS preferred geranylgeranyl diphosphate as the allylic substrate. The final product, as determined by TLC, had nine isoprene units. This suggests that the parasite synthesizes mainly ubiquinone-9 (UQ-9), as described for Trypanosoma brucei and Leishmania major. In fact, that was the length of the ubiquinone extracted from epimastigotes, as determined by high-performance liquid chromatography. Expression of TcSPPS was able to complement an Escherichia coli ispB mutant. A punctuated pattern in the cytoplasm of the parasite was detected by immunofluorescence analysis with a specific polyclonal antibody against TcSPPS. An overlapping fluorescence pattern was observed using an antibody directed against the glycosomal marker pyruvate phosphate dikinase, suggesting that this step of the isoprenoid biosynthetic pathway is located in the glycosomes. Co-localization in glycosomes was confirmed by immunogold electron microscopy and subcellular fractionation. Because UQ has a central role in energy production and in reoxidation of reduction equivalents, TcSPPS is promising as a new chemotherapeutic target.
Membrane Topology of the<i>Streptomyces lividans</i>Type I Signal Peptidases (2001)

Most bacterial membranes contain one or two type I signal peptidases (SPases) for the removal of signal peptides from export proteins. For Streptomyces lividans, four different type I SPases (denoted SipW, SipX, SipY, and SipZ) were previously described. In this communication, we report the experimental determination of the membrane topology of these SPases. A protease protection assay of SPase tendamistat fusions confirmed the presence of the N- as well as the C-terminal transmembrane anchor for SipY. SipX and SipZ have a predicted topology similar to that of SipY. These three S. lividans SPases are currently the only known prokaryotic-type type I SPases of gram-positive bacteria with a C-terminal transmembrane anchor, thereby establishing a new subclass of type I SPases. In contrast, S. lividans SipW contains only the N-terminal transmembrane segment, similar to most type I SPases of gram-positive bacteria. Functional analysis showed that the C-terminal transmembrane anchor of SipY is important to enhance the processing activity, both in vitro as well as in vivo. Moreover, for the S. lividans SPases, a relation seems to exist between the presence or absence of the C-terminal anchor and the relative contributions to the total SPase processing activity in the cell. SipY and SipZ, two SPases with a C-terminal anchor, were shown to be of major importance to the cell. Accordingly, for SipW, missing the C-terminal anchor, a minor role in preprotein processing was found.
Pentostatin (Nipent) in T-cell lymphomas. (2000)

Pentostatin (Nipent; SuperGen, San Ramon, CA), which is highly lymphocytotoxic, is an active agent in hairy cell leukemia. We therefore initiated a trial of this agent in T-cell lymphomas. Pentostatin was administered at a dose of 3.75 or 5.0 mg/m2/d intravenously for 3 days every 3 weeks to heavily pretreated patients with cutaneous and peripheral T-cell lymphomas. To date, there are 24 evaluable patients in the trial. Seventeen of these individuals have responded (complete or partial remission). The most common toxicities included granulocytopenia, nausea, renal insufficiency, CD4 suppression, and delayed herpes zoster. Pentostatin is an active agent in this group of diseases and merits further exploration.
Multiple-Ray Tracing Scheme for a Packed Bed of Non-Specular Spheres (1998)

Abstract Radiative heat transfer in a system of packed particles is important for numerous industrial processes. Most of the existing numerical work have focused on specular spheres. There has been relatively less numerical work on a packing of diffuse spheres. There are some numerical studies on diffuse spheres, but their foci were not on the adequacy of the Monte-Carlo ray-tracing scheme. This study examines this issue and presents a modified ray-tracing scheme in which multiple rays are utilized. The results show this scheme to be more accurate for certain porous medium.
Dry polymer for holographic recording (1987)

A dry polymeric mixture rendered red sensitive with a dye has been used to record interference gratings and holograms. Diffraction efficiencies of ~10% can be attained with exposures of ~94 mJ/cm(2). If necessary the reading step can be done just after the exposure or after a fixing step performed with light from a mercury lamp.
Shape from inconsistent silhouette for free viewpoint video (2008)

In this paper we present an efficient image-based rendering algorithm that obtains novel images from a set of views of the scene of interest. The approach described uses silhouette image data to compute the Visual Hull, the largest volume that is compatible with the silhouettes that delimit the objects of interest. Since the Visual Hull is not explicitly computed, this approach does not suffer from the quantization artifacts of volumetric approaches. In contrast to previous works, we explore how detection errors in the silhouettes affect the novel rendered view and propose a method to detect errors in the original silhouettes based on the consistency principle that states that the projection of the Visual Hull should exactly correspond with original silhouettes.
The Reaction Velocity of Ion Exchange (1944)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Reaction Velocity of Ion ExchangeF. C. Nachod and W. WoodCite this: J. Am. Chem. Soc. 1944, 66, 8, 1380–1384Publication Date (Print):August 1, 1944Publication History Published online1 May 2002Published inissue 1 August 1944https://pubs.acs.org/doi/10.1021/ja01236a050https://doi.org/10.1021/ja01236a050research-articleACS PublicationsRequest reuse permissionsArticle Views162Altmetric-Citations60LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Retrieval Topic Recurrent Memory Network for Remote Sensing Image Captioning (2020)

Remote sensing image (RSI) captioning aims to generate sentences to describe the content of RSIs. Generally, five sentences are used to describe the RSI in caption datasets. Every sentence can just focus on part of images' contents due to the different attention parts of annotation persons. One annotated sentence may be ambiguous compared with other four sentences. However, previous methods, treating five sentences separately, may generate an ambiguous sentence. In order to consider five sentences together, a collection of words, which named topic words contained common information among five sentences, is jointly incorporated into a captioning model to generate a determinate sentence that covers common contents in RSIs. Instead of employing a naive recurrent neural network, a memory network in which topic words can be naturally included as memory cells is introduced to generate sentences. A novel retrieval topic recurrent memory network is proposed to utilize the topic words. First, a topic repository is built to record the topic words in training datasets. Then, the retrieval strategy is exploited to obtain the topic words for a test image from topic repository. Finally, the retrieved topic words are incorporated into a recurrent memory network to guide the sentence generation. In addition to getting topics through retrieval, the topic words of test images can also be edited manually. The proposed method sheds light on controllability of caption generation. Experiments are conducted on two caption datasets to evaluate the proposed method.
Surface-mount cavity filter technology (2007)

A method is proposed to realize cavity resonator filters for cellular frequencies in surface-mount technology. The cavity resonators can be produced by molding techniques and subsequently soldered onto a circuit board, where a stripline structure in the circuit board makes the coupling between the resonators. The molded parts for all resonators of a given filter can be identical. Means are proposed for dealing with the alignment accuracy of the mounting process. Temperature effects due to thermal expansion can be accounted for. Three- and five-resonator band-pass filters have been designed using combined field and circuit simulation techniques, built, and measured.
Acid-Base Balance, Plasma Electrolytes and Production Performance of Adult Turkey Hens under Conditions of Increasing Ambient Temperature (1975)

Turkey hens were exposed to stepwise increases in ambient temperature from 21°C. to 25°C. to 30°C. to 35°C. at two-week intervals. Dietary calcium levels of 1.54, 2.01 and 2.48 percent were fed. Acid-base balance, plasma electrolytes and production performance were studied. The temperature increase caused a significant (P < 0.05) decrease in plasma sodium, calcium, and magnesium, and in egg production, shell thickness and egg weight and a significant (P < 0.05) increase in plasma potassium. There was no significant change in the acid-base balance of the blood as measured by blood PO2, PCO2 and pH. Egg production was not significantly correlated to blood gas activities or feed consumption but was significantly (|R| > 0.50, P < 0.01) correlated to plasma calcium and magnesium levels. Dietary calcium levels had no influence on the parameters measured.
Milk and Lactation: Some Social and Developmental Correlates Among 1,000 Infants (1982)

Breast-feeding and artificial feeding practices in a developing country were examined and related to some social and developmental factors. This was done during the course of a transverse-type growth study of 1,000 infants from birth to 26 months of age. Three types of feeding were identified: breast, mixed, and artificial. The families were divided into three social categories. To give time for the effects of the type of feeding, groups of children at 6, 8, 10, 12, 14, and 16 months of age were studied. In view of the lack of data on feeding effects upon large samples, the study was performed to assess the relative effects of feeding on early childhood development (Bayley Motor and Mental Scales), body length and weight, disease prevalence, clinical signs of allergies, and number of children in the family. Results showed that within the underprivileged group, there was evidence that breast-feeding promoted physical growth, sensory motor development, and resistance to infection. In mothers of both male and female infants who breast-fed, there was a protective effect against subsequent pregnancy up to ten months. Therefore, among the underprivileged in developing countries, every effort should be made to prolong breast-feeding and to assist mothers with health and nutrition education.
Reducing GPU offload latency via fine-grained CPU-GPU synchronization (2013)

GPUs are seeing increasingly widespread use for general purpose computation due to their excellent performance for highly-parallel, throughput-oriented applications. For many workloads, however, the performance benefits of offloading are hindered by the large and unpredictable overheads of launching GPU kernels and of transferring data between CPU and GPU.
Three Multicenter, Randomized, Double‐Blind, Placebo‐Controlled Studies Evaluating the Efficacy and Safety of Ustekinumab in Axial Spondyloarthritis (2018)

In these 3 placebo-controlled trials, efficacy of ustekinumab in the treatment of axial SpA was not demonstrated. The safety profile was consistent with that of studies in other indications.
Luminescence of Hexavalent Uranium in Ca<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">F</mml:mi></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math>and Sr<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">F</mml:mi></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math>Powders (1967)

A general investigation into the green luminescence of hexavalent uranium in calcium fluoride has been made in the temperature range 5 to 300\ifmmode^\circ\else\textdegree\fi{}K. Two types of spectra have been found, due to different centers. Absorption spectra for these were also observed. The luminescent spectrum has been interpreted as a no-phonon line with vibrational structure on the sides. Assignment of the lines and bands observed has been made on the basis of lattice vibrations, internal local modes of the center, and combinations of these. It has been possible to fit the temperature dependence of the width and the position of the no-phonon line with a theoretical curve using the Debye temperature of the lattice determined from the specific heat. The spectrum of hexavalent uranium in strontium fluoride has many similarities, although it shows evidence of other electronic transitions in the luminescent spectrum.
The vitamin D story: a collaborative effort of basic science and clinical medicine <sup>1</sup> (1988)

The discovery in 1919-1924 of vitamin D and its production in skin and foods by UV irradiation led to the elimination of rickets as a major medical problem. The identification and chemical preparation of vitamin D in the next decade provided large quantities of vitamin D to the physician for the treatment of a variety of metabolic bone diseases. Early in the 1960s, little was known about the function of vitamin D in causing mineralization of the skeleton, and hence in preventing the disease rickets in children and osteomalacia in adults. With the application of modern tools of biochemistry came the discovery that vitamin D must first be modified by 25-hydroxylation in the liver followed by 1 alpha-hydroxylation in the kidney to produce the vitamin D hormone 1 alpha,25-dihydroxyvitamin D3 [1,25-(OH)2D3]. This process is strongly feedback-regulated and is one of the major endocrine systems regulating plasma calcium and phosphorus concentrations. Furthermore, it is a major endocrine system regulating bone mass and state. With the chemical synthesis of 1,25-(OH)2D3 and many of its analogs has come the possibility of treating a number of metabolic bone diseases not previously managed adequately, such as vitamin D-resistant rickets, hypoparathyroidism, renal osteodystrophy, and osteoporosis. By using 1,25-(OH)2D3, considerable work has been carried out to understand how this hormone facilitates calcium transport across the intestinal membrane. Modern work is described on the molecular mechanism of action of the vitamin D hormone in eliciting the cellular responses that result in mineral homeostasis. The possible use of the vitamin D analogs to bring about differentiation of myelocytic-type leukemias and in the treatment of psoriasis has been an important new development. This paper will thus be a blend of basic science of the vitamin D system and the application of that information to the treatment of disease.
New method for the preparation of unsaturated axial 3-sterols (1969)

R. Baker, J. Hudec and K. L. Rabone, J. Chem. Soc. C, 1969, 1605 DOI: 10.1039/J39690001605
Monocrotaline: Histological Damage and Oxidant Activity in Brain Areas of Mice (2012)

This work was designed to study MCT effect in histopathological analysis of hippocampus (HC) and parahippocampal cortex (PHC) and in oxidative stress (OS) parameters in brain areas such as hippocampus (HC), prefrontal cortex (PFC), and striatum (ST). Swiss mice (25-30 g) were administered a single i.p. dose of MCT (5, 50, or 100 mg/kg) or 4% Tween 80 in saline (control group). After 30 minutes, the animals were sacrificed by decapitation and the brain areas (HC, PHC, PFC, or ST) were removed for histopathological analysis or dissected and homogenized for measurement of OS parameters (lipid peroxidation, nitrite, and catalase) by spectrophotometry. Histological evaluation of brain structures of rats treated with MCT (50 and 100 mg/kg) revealed lesions in the hippocampus and parahippocampal cortex compared to control. Lipid peroxidation was evident in all brain areas after administration of MCT. Nitrite/nitrate content decreased in all doses administered in HC, PFC, and ST. Catalase activity was increased in the MCT group only in HC. In conclusion, monocrotaline caused cell lesions in the hippocampus and parahippocampal cortex regions and produced oxidative stress in the HC, PFC, and ST in mice. These findings may contribute to the neurological effects associated with this compound.
An Organic Solid State Injection Laser (2000)

We report on electrically driven amplified spontaneous emission and lasing in tetracene single crystals using field-effect electrodes for efficient electron and hole injection. For laser action, feedback is provided by reflections at the cleaved edges of the crystal resulting in a Fabry-Perot resonator. Increasing the injected current density above a certain threshold value results in the decreasing of the spectral width of the emission from 120 millielectron volts to less than 1 millielectron volt because of gain narrowing and eventually laser action. High electron and hole mobilities as well as balanced charge carrier injection lead to improved exciton generation in these gate-controlled devices. Moreover, the effect of charge-induced absorption is substantially reduced in high-quality single crystals compared with amorphous organic materials.
Two-prism setup for surface plasmon resonance studies (2005)

A two-prism experimental arrangement having wide angular scan ranges for the study of surface plasmon resonance is presented. The setup has a single rotating element instead of a high cost goniometer and a stationary photodetector which is positioned such that it always receives the reflected beam normally. The usefulness of the setup has been verified by experimental and theoretical studies of plasmon resonance at an Au–air interface.
Householder factorizations of unitary matrices (2010)

A method to construct all representations of finite dimensional unitary matrices as the product of Householder reflections is given. By arbitrarily severing the state space into orthogonal subspaces, the method may, e.g., identify the entangling and single-component quantum operations that are required in the engineering of quantum states of composite (multipartite) systems. Earlier constructions are shown to be extreme cases of the unifying scheme that is presented here.
The autonomic operating system research project (2013)

Traditionally, hypervisors, operating systems, and runtime systems have been providing an abstraction layer over the bare-metal hardware. Traditional abstractions, however, do not consider for non-functional requirements such as system-level constraints or users' objectives. As these requirements are gaining increasing importance, researchers are looking into making user-specified and system-level objectives first-class citizens in the computer systems' realm.
Oriented cell growth on self-assembled bacteriophage M13 thin films (2008)

Fibrillar M13 bacteriophages were used as basic building blocks to generate thin films with aligned nanogrooves, which, upon chemical grafting with RGD peptides, guide cell alignment and orient the cell outgrowth along defined directions.
Gas permeation performance of cellulose hollow fiber membranes made from the cellulose/N‐methylmorpholine‐N‐oxide/H<sub>2</sub>O system (2003)

Abstract Cellulose hollow fiber membranes (CHFM) were prepared using a spinning solution containing N‐methylmorpholine‐N‐oxide as solvent and water as a nonsolvent additive. Water was also used as both the internal and external coagulant. It was demonstrated that the phase separation mechanism of this system was delayed demixing. The CHFM was revealed to be homogeneously dense structure after desiccation. The gas permeation properties of CO 2 , N 2 , CH 4 , and H 2 through CHFM were investigated as a function of membrane water content and operation pressure. The water content of CHFM had crucial influence on gas permeation performance, and the permeation rates of all gases increased sharply with the increase of membrane water content. The permeation rate of CO 2 increased with the increase of operation pressure, which has no significant effect on N 2 , H 2 , and CH 4 . At the end of this article a detailed comparison of gas permeation performance and mechanism between the CHFM and cellulose acetate flat membrane was given. © 2003 Wiley Periodicals, Inc. J Appl Polym Sci 91: 1873–1880, 2004