gebhart/patrepeval huggingface dataset:
Multiresolution analysis of remotely sensed imagery (1991)

Abstract A multiresolution method for analysing remotely sensed images is described, in which correlation filters, based on two-point differences, are applied over a range of scales with octave separation. When applied to typical Earth backgrounds viewed from space, the measured probability distributions of filter outputs exhibit strongly non-Gaussian statistics and satisfy scaling laws which allow a representation of the imagery in terms of fractal geometry. The method may be used as a basis for image, or image-region, characterization and, using the tails of the resulting normalised distributions, for the identification of those localized image features which are most unusual; that is, have lowest relative probability.
Development of 2 Bromodomain and Extraterminal Inhibitors With Distinct Pharmacokinetic and Pharmacodynamic Profiles for the Treatment of Advanced Malignancies (2019)

INCB057643 exhibited a more favorable PK profile versus INCB054329; exposure-dependent thrombocytopenia was observed with both drugs which limited the target inhibition that could be safely maintained. Further efforts are required to identify patient populations that can benefit most, and an optimal dosing scheme to maximize therapeutic index.
Binaural signal processing (2011)

The human binaural system has a number of astonishing capabilities that are essential for the formation of our aural worlds. To mimic these, signal-processing models of the binaural system have been built and are constantly improved. In the following, the current state of the art of these models will be reviewed and their potential with respect to practical application will be discussed. Further, trends for future developments in these models will be considered. In this context, reference will be given to activities of AABBA, an open international circle of researchers with a special interest in the application of binaural models. Generic application areas for binaural models are, among others, aural virtual environments, hearing aids, assessment of product-sound quality, room acoustics, speech technology, audio technology, acoustic surveillance, robotic ears and tools for research into auditory physiology and perception.
Trabeculectomy With Combined Use of Subconjunctival Collagen Implant and Low-dose Mitomycin C (2012)

Trabeculectomy with implantation of an Ologen implant and use of low-dose MMC appears to offer encouraging short-term results for IOP control in eyes with primary open-angle glaucoma.
Genome structure of a <i>Saccharomyces cerevisiae</i> strain widely used in bioethanol production (2009)

Bioethanol is a biofuel produced mainly from the fermentation of carbohydrates derived from agricultural feedstocks by the yeast Saccharomyces cerevisiae. One of the most widely adopted strains is PE-2, a heterothallic diploid naturally adapted to the sugar cane fermentation process used in Brazil. Here we report the molecular genetic analysis of a PE-2 derived diploid (JAY270), and the complete genome sequence of a haploid derivative (JAY291). The JAY270 genome is highly heterozygous (approximately 2 SNPs/kb) and has several structural polymorphisms between homologous chromosomes. These chromosomal rearrangements are confined to the peripheral regions of the chromosomes, with breakpoints within repetitive DNA sequences. Despite its complex karyotype, this diploid, when sporulated, had a high frequency of viable spores. Hybrid diploids formed by outcrossing with the laboratory strain S288c also displayed good spore viability. Thus, the rearrangements that exist near the ends of chromosomes do not impair meiosis, as they do not span regions that contain essential genes. This observation is consistent with a model in which the peripheral regions of chromosomes represent plastic domains of the genome that are free to recombine ectopically and experiment with alternative structures. We also explored features of the JAY270 and JAY291 genomes that help explain their high adaptation to industrial environments, exhibiting desirable phenotypes such as high ethanol and cell mass production and high temperature and oxidative stress tolerance. The genomic manipulation of such strains could enable the creation of a new generation of industrial organisms, ideally suited for use as delivery vehicles for future bioenergy technologies.
PHYTOPLANKTON LIPIDS: INTERSPECIFIC DIFFERENCES AND EFFECTS OF NITRATE, SILICATE AND LIGHT‐DARK CYCLES<sup>1</sup> (1981)

ABSTRACT The lipid content of various phytoplankton species was measured in response to nitrogen and silicon limitation and over the cell cycle in synchronized cultures. In a survey of 30 species it was found that during log‐phase growth, green algae contained an average of 17.1% total lipids (% of total dry weight), whereas diatoms contained an average of 24.5%. Nitrogen deprivation for 4 to 9 days resulted in 2‐ to 3‐fold increases in the lipid content of green algae, whereas both increases and decreases were noted in diatoms, depending on the species. The greatest lipid content measured in the study was 72% in Monallantus salina (strain GSB Sticho) which had been deprived of nitrogen for 9 days. Nitrate replenishment in a nitrogen starved culture of Oocystis polymorpha Groover & Bold showed that the excess cellular lipids do not rapidly disappear during recovery, until cell division occurs. A silicate deprivation experiment with Cyclotella cryptica Reimann, Lewin & Guillard (strain 7c) showed an increase in the total cellular lipid fraction from. 30 to 42% of dry weight within 6 h of the onset of silicon limitation, while the mass of lipid material per cell doubled within 12 h. The total lipid fraction in O. polymorpha was found to remain constant over the cell cycle in synchronized cultures regardless of the light regime. The data presented provided the first internally consistent study of phytoplankton lipids for a wide range of species and several growth conditions.
A selective cyclooxygenase-2 inhibitor, NS-398, inhibits cell growth by cell cycle arrest in a human malignant fibrous histiocytoma cell line. (2004)

Our results indicate that NS-398 inhibits the cell growth and induces G0/G1 arrest in MFH-ino cells accompanied with up-regulation of P21WAF1.
Enzymatically Degradable Mussel-Inspired Adhesive Hydrogel (2011)

Mussel-inspired adhesive hydrogels represent innovative candidate medical sealants or glues. In the present work, we describe an enzyme-degradable mussel-inspired adhesive hydrogel formulation, achieved by incorporating minimal elastase substrate peptide Ala-Ala into the branched poly(ethylene glycol) (PEG) macromonomer structure. The system takes advantage of neutrophil elastase expression upregulation and secretion from neutrophils upon recruitment to wounded or inflamed tissue. By integrating adhesive degradation behaviors that respond to cellular cues, we expand the functional range of our mussel-inspired adhesive hydrogel platforms. Rapid (<1 min) and simultaneous gelation and adhesion of the proteolytically active, catechol-terminated precursor macromonomer was achieved by addition of sodium periodate oxidant. Rheological analysis and equilibrium swelling studies demonstrated that the hydrogel is appropriate for soft tissue-contacting applications. Notably, hydrogel storage modulus (G') achieved values on the order of 10 kPa, and strain at failure exceeded 200% strain. Lap shear testing confirmed the material's adhesive behavior (shear strength: 30.4 ± 3.39 kPa). Although adhesive hydrogel degradation was not observed during short-term (27 h) in vitro treatment with neutrophil elastase, in vivo degradation proceeded over several months following dorsal subcutaneous implantation in mice. This work represents the first example of an enzymatically degradable mussel-inspired adhesive and expands the potential biomedical applications of this family of materials.
Significance of Total Synthesis of Bioactive Compounds (2001)

The first total synthesis and development of a variety of bioactive compounds have been accomplished mainly by using carbohydrates, if any, as chiral sources. The target molecules are macrolide antibiotics, aminoglycoside antibiotics, antifungal antibiotics, antitumor antibiotics, a side-chain of b-lactam antibiotics, enzyme inhibitors including glycosidase inhibitors, central nervous system - affecting products, nonsteroidal progesterone receptor ligands, mussel-attachment inhibitors and so on.
6,9.alpha.-Oxido-11.alpha.,15.alpha.-dihydroxyprosta-6,(E)-13-dienoic acid methyl ester and 6,9.alpha.:6,11.alpha.-dioxido-15.alpha.-hydroxyprost-(E)-13-enoic acid methyl ester. Two isomeric forms of prostacyclin (PGI2) (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT6,9.alpha.-Oxido-11.alpha.,15.alpha.-dihydroxyprosta-6,(E)-13-dienoic acid methyl ester and 6,9.alpha.:6,11.alpha.-dioxido-15.alpha.-hydroxyprost-(E)-13-enoic acid methyl ester. Two isomeric forms of prostacyclin (PGI2)Katsuichi Shimoji, Yoshitaka Konishi, Yoshinobu Arai, Masaki Hayashi, and Hisashi YamamotoCite this: J. Am. Chem. Soc. 1978, 100, 8, 2547–2548Publication Date (Print):April 1, 1978Publication History Published online1 May 2002Published inissue 1 April 1978https://pubs.acs.org/doi/10.1021/ja00476a047https://doi.org/10.1021/ja00476a047research-articleACS PublicationsRequest reuse permissionsArticle Views68Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Synthesis of 6-<i>O</i>-α-<scp>D</scp>-Galactosyl α-Cyclodextrin by Coffee Bean α-Galactosidase (1992)

Journal Article Synthesis of 6-O-α-D-Galactosyl α-Cyclodextrin by Coffee Bean α-Galactosidase Get access Sumio Kitahata, Sumio Kitahata Osaka Municipal Technical Research Institute, 1–6–50, Morinomiya Jyoto-ku, Osaka 536, Japan Search for other works by this author on: Oxford Academic Google Scholar Koji Hara, Koji Hara Osaka Municipal Technical Research Institute, 1–6–50, Morinomiya Jyoto-ku, Osaka 536, JapanCarbohydrate Research Laboratory, Ensuiko Sugar Refining Co., Ltd., 13–46, Daikoku-cho, Tsurumi-ku, Yokohama 230, Japan Search for other works by this author on: Oxford Academic Google Scholar Koki Fujita, Koki Fujita Osaka Municipal Technical Research Institute, 1–6–50, Morinomiya Jyoto-ku, Osaka 536, JapanCarbohydrate Research Laboratory, Ensuiko Sugar Refining Co., Ltd., 13–46, Daikoku-cho, Tsurumi-ku, Yokohama 230, Japan Search for other works by this author on: Oxford Academic Google Scholar Nobuhiro Kuwahara, Nobuhiro Kuwahara Osaka Municipal Technical Research Institute, 1–6–50, Morinomiya Jyoto-ku, Osaka 536, JapanCarbohydrate Research Laboratory, Ensuiko Sugar Refining Co., Ltd., 13–46, Daikoku-cho, Tsurumi-ku, Yokohama 230, Japan Search for other works by this author on: Oxford Academic Google Scholar Kyoko Koizumi Kyoko Koizumi Osaka Municipal Technical Research Institute, 1–6–50, Morinomiya Jyoto-ku, Osaka 536, JapanFaculty of Pharmaceutical Sciences, Mukogawa Women’s University, 11-68, Koshien Kyuban-cho, Nishinomiya 663, Japan Search for other works by this author on: Oxford Academic Google Scholar Bioscience, Biotechnology, and Biochemistry, Volume 56, Issue 9, 1 January 1992, Pages 1518–1519, https://doi.org/10.1271/bbb.56.1518 Published: 01 January 1992 Article history Published: 01 January 1992 Received: 21 May 1992
Practical privacy-preserving location-sharing based services with aggregate statistics (2014)

Location-sharing-based services (LSBSs) allow users to share their location with their friends in a sporadic manner. In currently deployed LSBSs users must disclose their location to the service provider in order to share it with their friends. This default disclosure of location data introduces privacy risks. We define the security properties that a privacy-preserving LSBS should fulfill and propose two constructions. First, a construction based on identity based broadcast encryption (IBBE) in which the service provider does not learn the user's location, but learns which other users are allowed to receive a location update. Second, a construction based on anonymous IBBE in which the service provider does not learn the latter either. As advantages with respect to previous work, in our schemes the LSBS provider does not need to perform any operations to compute the reply to a location data request, but only needs to forward IBBE ciphertexts to the receivers. We implement both constructions and present a performance analysis that shows their practicality. Furthermore, we extend our schemes such that the service provider, performing some verification work, is able to collect privacy-preserving aggregate statistics on the locations users share with each other.
Combining conventional and stroma-derived tumour markers in pancreatic ductal adenocarcinoma (2015)

PDAC is characterized by an abundant stroma. These initial observations indicate that the stroma can be a source of PDAC tumour markers that are found in different compartments of the cancer, thus reflecting different aspects of tumour biology.
Mobile Edge Fog Computing in 5G Era: Architecture and Implementation (2016)

In the recent past there has been much research and development on cloud based computing. While cloud computing provides huge opportunities, it also imposes several challenges. One of the challenges that current data network operators and future 5G network are foreseeing is huge increase in data traffic. To fulfill such exponential data traffic growth, along with other user expectation, requires multiple innovative approaches and re-consideration of the current network design principals. Mobile Edge Fog computing, as proposed in this paper offers huge opportunities to future data network operators, as well as to equipment vendors. Due to its relatively newer concept, still much research is ongoing and detail architecture is still evolving. This paper proposes and discusses a novel Mobile Edge Computing design and architecture, along with real-time implementation details of the proposed solutions. It exploits many benefits of D2D by incorporating D2D functionalities into the proposed relay-gateways. The application running on top of the proposed network shows significant benefits e.g. in terms of delay as well as core-network signalling and data offloading.
Discovery of novel 1,2,3-triazole derivatives as anticancer agents using QSAR and in silico structural modification (2015)

Considerable attention has been given on the search for novel anticancer drugs with respect to the disease sequelae on human health and well-being. Triazole is considered to be an attractive scaffold possessing diverse biological activities. Structural modification on the privileged structures is noted as an effective strategy towards successful design and development of novel drugs. The quantitative structure-activity relationships (QSAR) is well-known as a powerful computational tool to facilitate the discovery of potential compounds. In this study, a series of thirty-two 1,2,3-triazole derivatives (1-32) together with their experimentally measured cytotoxic activities against four cancer cell lines i.e., HuCCA-1, HepG2, A549 and MOLT-3 were used for QSAR analysis. Four QSAR models were successfully constructed with acceptable predictive performance affording R CV ranging from 0.5958 to 0.8957 and RMSECV ranging from 0.2070 to 0.4526. An additional set of 64 structurally modified triazole compounds (1A-1R, 2A-2R, 7A-7R and 8A-8R) were constructed in silico and their predicted cytotoxic activities were obtained using the constructed QSAR models. The study suggested crucial moieties and certain properties essential for potent anticancer activity and highlighted a series of promising compounds (21, 28, 32, 1P, 8G, 8N and 8Q) for further development as novel triazole-based anticancer agents.
Photopolymerization Kinetics and Structure Development of Templated Lyotropic Liquid Crystalline Systems (2001)

The templating of the ordered nanostructures of lyotropic liquid crystals (LLC) onto organic polymers has recently been of great interest. This work describes the polymerization and segregation behavior of polar and nonpolar monomers in an LLC environment. Nonpolar monomers partition to the oil-soluble domains of the LLC phase, whereas more polar monomers segregate at the interface of the liquid crystals. The polymerization kinetics in both cases are significantly influenced by the LLC phase morphologies although in different ways. The nonpolar monomers exhibit the fastest polymerization rates in micellar aggregates. This behavior is a result of an increase in the rate of propagation, induced by higher local concentrations of monomer in the micelles as compared to other mesophases. For more polar monomers, the opposite polymerization behavior is observed. The fastest polymerizations for these monomers are observed in the highly ordered lamellar mesophase with the minimum polymerization rate observed in the isotropic micellar phase. In this case, the enhanced polymerization rates are a consequence of depressed termination rates. This decrease in termination rate is due to diffusional limitations induced by the high degree of order in a lamellar mesophase. Initial results also indicate that the original LLC phase morphologies are retained after photopolymerization.
Ca <sup>2+</sup> -regulated structural changes in troponin (2005)

Troponin senses Ca2+ to regulate contraction in striated muscle. Structures of skeletal muscle troponin composed of TnC (the sensor), TnI (the regulator), and TnT (the link to the muscle thin filament) have been determined. The structure of troponin in the Ca(2+)-activated state features a nearly twofold symmetrical assembly of TnI and TnT subunits penetrated asymmetrically by the dumbbell-shaped TnC subunit. Ca ions are thought to regulate contraction by controlling the presentation to and withdrawal of the TnI inhibitory segment from the thin filament. Here, we show that the rigid central helix of the sensor binds the inhibitory segment of TnI in the Ca(2+)-activated state. Comparison of crystal structures of troponin in the Ca(2+)-activated state at 3.0 angstroms resolution and in the Ca(2+)-free state at 7.0 angstroms resolution shows that the long framework helices of TnI and TnT, presumed to be a Ca(2+)-independent structural domain of troponin are unchanged. Loss of Ca ions causes the rigid central helix of the sensor to collapse and to release the inhibitory segment of TnI. The inhibitory segment of TnI changes conformation from an extended loop in the presence of Ca2+ to a short alpha-helix in its absence. We also show that Anapoe, a detergent molecule, increases the contractile force of muscle fibers and binds specifically, together with the TnI switch helix, in a hydrophobic pocket of TnC upon activation by Ca ions.
Flow‐sensitive runtime estimation: an enhanced hot spot detection heuristics for embedded Java just‐in‐time compilers (2015)

Summary Java just‐in‐time compilers often compile only hot methods because the compilation overhead is a part of the running time. This requires precise and efficient hot spot detection , which includes distinguishing hot methods from cold ones, detecting them as early as possible, and paying a small detection overhead. Hot spot detection is especially important in embedded applications because they show more of a start‐up phase behavior of a regular application where methods are not executed heavily, so the hot methods are not definite. Because a long‐running method is likely to be a hot method, we can detect a hot method by measuring its running time during interpretation. However, precise measurement of the running time during execution is too expensive, especially in embedded systems, so many counter‐based heuristics have been proposed to estimate it such as Oracle's HotSpot heuristic. One problem is that although the overhead of these heuristics is low, they do not estimate the running time precisely, which may lead to imprecise hot spot detection.This paper proposes a new hot spot detection heuristic called flow‐sensitive runtime estimation , which can estimate the running time more precisely than others with a relatively low overhead. It only counts important bytecode instructions dynamically, but it can obtain the precise count of all interpreted bytecode instructions with a simple arithmetic calculation. We also propose a static analysis technique to predict those hot methods which spends a huge execution time once invoked, so as to compile them at their first invocation. Our experimental results show that these techniques can improve the performance by as much as an average of 7.4% compared with the HotSpot heuristic for the benchmarks when they run once, which is often regarded as showing the start‐up phase behavior. Even for real embedded Java applications such as the digital TV Java Xlet applications, our techniques can improve the user response time by an average of 7.1%. Copyright © 2015 John Wiley & Sons, Ltd.
How to relate bit weight and rotary speed to bit hydraulic horsepower (1975)

Smith Tool presents a method that can be used to relate bit weight and rotary speed to bit hydraulic horsepower (BHHP) and then to determine the rate of penetration. Other calculation methods that include determination of BHHP or specific BHHP seldom relate these values into tangible or practical quantities that can be used at the rig level. Either of 2 charts presented can be used at the rig level while drilling is in progress to make a bit weight, bit speed, or mud-pump operational change for improvement of drilling costs. Some contractors require the reporting of BHHP in their morning reports. If calculated daily, it can be effectively utilized, as illustrated by 2 examples.
Surveying the Field : Gender Equity in Higher Education :Selected Papers from Succeding as Women in Higher Education Conference at SUNY Cortland (2011)

Human error has played a role in several large-scale hazardous materials events. To assess how human error and time of occurrence may have contributed to acute chemical releases, data from the Hazardous Substances Emergency Events Surveillance (HSEES) system for 1996-2003 were analyzed. Analyses were restricted to events in mining or manufacturing where human error was a contributing factor. The temporal distribution of releases was also evaluated to determine if the night shift impacted releases due to human error. Human error-related events in mining and manufacturing resulted in almost four times as many events with victims and almost three times as many events with evacuations compared with events in these industries where human error was not a contributing factor (10.3% versus 2.7% and 11.8% versus 4.5%, respectively). Time of occurrence of events attributable to human error in mining and manufacturing showed a widespread distribution for number of events, events with victims and evacuations, and hospitalizations and deaths, without apparent increased occurrence during the night shift. Utilizing human factor engineering in both front-end ergonomic design and retrospective incident investigation provides one potential systematic approach that may help minimize human error in workplace-related acute chemical releases and their resulting injuries.