gebhart/patrepeval huggingface dataset:
Design and fabrication of two-pole monolithic bulk acoustic filters (2002)

A new class of miniature monolithic filters has been fabricated in the 1-GHz to 1.5-GHz range. The devices are two-pole ladder filters which incorporate two inductors, a coupling capacitor, and two bulk acoustic resonators. They are characterized by small size and weight, low insertion loss (typically between 1 and 1.5 dB), narrow passbands (between 2 and 5%), and potentially very low cost. Filters have been fabricated on both high-resistivity silicon and semiinsulating gallium arsenide substrates. Fabrication is completely compatible with all monolithic microwave IC components, and thus integrating these devices with active components on the same wafer is a straightforward procedure.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
[A fibrin clot containing of anticancer drug for intra-arterial chemo-embolization therapy. (1) Experimental study on basic characteristics in dogs]. (1985)

A new embolus consisting of a fibrin clot containing an anticancer drug (mitomycin-C) was devised. An experimental study was then performed using the new embolus in dogs and several interesting characteristics were observed. The fibrin clot containing mitomycin-C was in a fluid from when infused and its action as an embolus did not occur until it reached a target artery. The fibrin clot containing mitomycin-C formed a mold within of the arteries in which it was embolized and was soluble with urokinase during a ten-hour period. The release of mitomycin-C from the fibrin clot was sustained over sixty hours. The intraarterial occlusion formed by fibrin clot was temporary, and recanalization was observed over forty-eight by hours by both angiography and pathological examination.
Building reconstruction from optical and range images (2002)

A technique is introduced for extracting and reconstructing a wide class of building types from a registered range image and optical image. An attentional focus stage, followed by model indexing, allows top-down robust surface fitting to reconstruct the 3D nature of the buildings in the data. Because of the effectiveness of model selection, top-down processing of noisy range data still succeeds and the algorithm is capable of detecting and reconstructing several different building roof classes, including flat single level, flat multi-leveled, peaked, and curved rooftops. The algorithm is applicable to range data that may have been collected from several different range sensor types. We demonstrate reconstructions of different buildings classes in the presence of large amounts of noise. Our results underline the usefulness of range data when processed in the context of a focus-of-attention area derived from the monocular optical image.
GFP expression in the mammary gland for imaging of mammary tumor cells in transgenic mice. (2002)

To examine the behavior of tumor cells in tumors developing directly from mammary tissue in transgenic models, we have evaluated transgenic mice expressing green fluorescent protein (GFP). Using the mouse mammary virus promoter (MMTV) to directly drive expression of GFP, we find low levels of fluorescence in the mammary and salivary glands of transgenic animals. Using MMTV-Cre or WAP-Cre in combination with the Cre-activatable CAG-CAT-EGFP construct, we find stronger expression of GFP that is still tissue specific. These animals provide a range of expression of GFP that is suitable for analysis of transgenic mammary tumors and metastases in vivo at the single cell level of resolution.
Structure-function relationships of the calcium binding sites of the sarcoplasmic reticulum Ca(2+)-ATPase. (1998)

Site-directed mutagenesis studies of the structure and function of the Ca2+ binding sites of the sarcoplasmic reticulum Ca(2+)-ATPase are reviewed. The Ca2+ binding properties of six mutants with alterations to amino acid residues with oxygen-containing side chains in the membrane segments M4, M5, M6, and M8 were investigated. The mutations to Glu309 in M4, Glu771 in M5, Asn796, Thr799, and Asp800 in M6 all disrupted Ca2+ occlusion, suggesting that the side chains of these residues donate oxygen ligands to Ca2+ binding at the high-affinity sites and/or are involved in conformational changes that occlude the sites. Alanine substitution of Glu908 in transmembrane segment M8 did not prevent Ca2+ occlusion, thereby excluding this residue from playing a central role in Ca2+ coordination. Titrations of Ca2+ activation of phosphorylation from ATP and of inhibition by Ca2+ of phosphorylation from Pi allowed us to assign Ca2+ liganding residues separately to the two high-affinity Ca2+ sites. Hence, residues Glu771 and Thr799 are associated with the site binding the first calcium ion in the sequential mechanism ("site 1"), whereas Glu309 and Asn796 are associated with the site binding the second calcium ion ("site 2"), and Asp800 donates Ca2+ ligands to both sites. On this basis we discuss two possible structural models for the Ca2+ sites.
DEGseq: an R package for identifying differentially expressed genes from RNA-seq data (2009)

The R package and a quick-start vignette is available at http://bioinfo.au.tsinghua.edu.cn/software/degseq
The PTEN Long N-tail is intrinsically disordered: increased viability for PTEN therapy (2013)

Aberrant activation of the PI3K/Akt/mTOR pathway is observed in several cancers and hyper proliferative disorders. PTEN, a tumor suppressor gene, negatively regulates the PI3K/Akt/mTOR pathway. Inhibitors of various components of this pathway are currently being used for cancer therapy. However, the use of these small molecule inhibitors remains limited due to the presence of compensatory feedback loops within the pathway such that inhibition of one oncogenic molecule often results in the activation of another oncogenic molecule resulting in the development of chemoresistance. One novel strategy that has emerged as a means to circumvent the problem of feedback signaling is by activating tumor suppressor genes that abrogate oncogenic pathways and regress tumor growth. In this regard, a newly identified isoform of the PTEN protein shows promise for use in tumors with elevated PI3K/Akt/mTOR signaling. This isoform is a translational variant of PTEN, termed as PTEN Long, and has additional 173 amino acids at its N-terminus (N-173) than normal PTEN. The N-173 region is required for PTEN secretion and transport across the body. Given the potential of this N-173 region to act as a drug delivery system for PTEN, we herein analyze the structural properties of this region. This N-173 tail has a large intrinsically disordered region (IDR) and is composed of highly charged basic residues. Further, the region is enriched in potential linear binding motifs, protein-binding sites and post-translational modifications (PTMs) indicating its probable role in PTEN function and transport across cells. An extensive analysis of this region is warranted to better exploit its structural and biophysical peculiarities to drug discovery and drug delivery applications.
A Potential Virulence Gene,<i>hyl</i><sub>Efm</sub>, Predominates in<i>Enterococcus faecium</i>of Clinical Origin (2003)

An open reading frame (hyl(Efm)) with homologies to previously described hyaluronidase genes has been identified in nonstool isolates of Enterococcus faecium. E. faecium isolates (n=577) from diverse sources were screened for the presence of hyl(Efm) and esp(Efm), a putative virulence gene associated with epidemic E. faecium strains. The presence of esp(Efm) was roughly twice that of hyl(Efm), but both were found primarily in vancomycin-resistant E. faecium isolates in nonstool cultures obtained from patients hospitalized in the United States. These data suggest that specific E. faecium strains may be enriched in determinants that make them more likely to cause clinical infections. Differences in the prevalence of these strains may help explain variations in the clinical importance of multiresistant E. faecium across different continents.
Surface-initiated Polymerization as a Novel Strategy towards Preparation of Organic Semiconducting Polymer Thin Films (2011)

Organic semiconducting polymer thin films are core materials for organic electronics that are conventionally prepared by solution processing techniques. Despite having the advantage of easy and fast thin film manufacturing, solution techniques have intrinsic drawbacks, such as disordered and poor molecular organization in the film (often resulting in poor device performance), as well as insufficient stabilities of the films and resulting devices. To improve this situation, we designed a novel “bottom-up” fabrication of surface-immobilized organic semiconducting thin films through in situ polymerization. This new strategy will allow high degree of control over molecular organization which therefore results in improved free charge carrier transport efficiency. An additional benefit of this strategy will be the enhanced stability of thin films due to covalent attachment of the resulting conducting polymers to the surface. Initially, we developed an approach towards deposition of surface-bound semiconducting polymer thin films via in situ electropolymerization. When the resulting thin films were used as hole transporting materials in photovoltaic devices, they demonstrated enhanced photocurrent generation quantum efficiencies and remarkable stabilities as compared to conventional spin- casted thin films. Based on the promising results from this initial attempts, a chemical surface-initiated in situ polymerization based on Ni catalyst transfer living Kumada polycondensation was developed using highly efficient Ni(II) external catalytic initiator. Thin polythiophene films with improved surface morphologies were successfully grafted on substrates after systematic optimization of the experimental conditions. As an important extension of this strategy, we also prepared nanopatterned surface-immobilized polythiophene thin films as a hole transporting counterpart of the ideal heterostructures for bulk-heterojunction type organic photovoltaic devices. In a parallel study, surface-immobilized semiconducting polymer thin films were prepared by stepwise surface-initiated in situ polymerization using highly efficient Cu-catalyzed alkyne-azide cycloaddition (click) reaction. In this project, we found that stepwise preparation of semiconducting polymer thin films not only promises complete control over surface morphology, thickness, and molecular composition of the resulting polymer films but also allows building complex copolymer thin films with desired photophysical properties. Taken together, those three methods represent a powerful “bottom-up” alternative to the traditional methods of preparation of semiconducting polymer thin films.
Application and Modifications of Minimal Disease Activity Measures for Patients with Psoriatic Arthritis Treated with Adalimumab: Subanalyses of ADEPT (2013)

ADEPT results indicated that significantly more patients treated with adalimumab achieved MDA by Week 24 compared with placebo. Modification of the MDA by replacing PASI ≤ 1 with PGA assessments did not alter the results, which may improve feasibility of practical use of the index.
Investigation of contrast enhancement in CT of the liver: the need for improved methods. (1993)

Investigation of contrast enhancement in CT of the liver: the need for improved methods.G D Dodd, 3rd and R L BaronAudio Available | Share
<i>PLA2G7</i> Genotype, Lipoprotein-Associated Phospholipase A <sub>2</sub> Activity, and Coronary Heart Disease Risk in 10 494 Cases and 15 624 Controls of European Ancestry (2010)

Unlike Lp-PLA2 activity, PLA2G7 variants associated with modest effects on Lp-PLA2 activity were not associated with cardiovascular risk markers, coronary atheroma, or CHD. Larger association studies, identification of single-nucleotide polymorphisms with larger effects, or randomized trials of specific Lp-PLA2 inhibitors are needed to confirm or refute a contributory role for Lp-PLA2 in CHD.
Susceptibility of different provenances of<i>Pinus sylvestris, Pinus Contorta</i>and<i>Picea abies</i>to<i>Gremmeniella abietina</i> (1998)

Summary In a randomized block factorial experiment, 1200 seedlings from four provenances, each of Pinus sylvestris, Pinus contorta and Picea abies were inoculated with conidia (2 × 10 4 and 1 × 10 6 conidia/seedling) of Gremmeniella abietina (Brunchorstia pinea) , isolated from P. contorta plantations in northern Sweden. A further 600 seedlings were left as controls. The occurrence of symptoms and the extension of dead tissues on the annual shoots were recorded 13 months after inoculation. Only the higher spore dose resulted in significant infection. P. sylvestris and P. contorta seedlings were equally susceptible (53% infected), and significantly more infected than P. abies seedlings (39%). The annual shoots of P. sylvestris and P. abies were affected to 43% and 37% of their length, which was significantly more than 15% of the length of P. Contorta shoots. The frequency of affected seedlings differed between the most southern and northern provenances of P. sylvestris and P. abies , and between the northwestern and the south‐eastern provenance of P. contorta Twenty‐six months after inoculation, a higher proportion of P. contorta seedlings than P. sylvestris and P. abies seedlings had recovered, and a lower proportion of P. contorta than P. sylvestris and P. abies seedlings had died. This paper discusses why P. sylvestris was found to be more susceptible to G. abietina than P. contorta in this experiment, while the reverse is found in plantations in northern Sweden.
Stealth probing: efficient data-plane security for IP routing (2006)

IP routing is notoriously vulnerable to accidental misconfiguration and malicious attack. Although secure routing protocols are an important defense, the data plane must be part of any complete solution. Existing proposals for secure (link-level) forwarding are heavy-weight, requiring cryptographic operations at each hop in a path. Instead, we propose a light-weight data-plane mechanism (called stealth probing) that monitors the availability of paths in a secure fashion, while enabling the management plane to home in on the location of adversaries by combining the results of probes from different vantage points (called Byzantine tomography). We illustrate how stealth probing and Byzantine tomography can be applied in today's routing architecture, without requiring support from end hosts or internal routers.
B-Cell Precursor Bone Marrow Reconstitution After Bone Marrow Transplantation (1994)

Bone marrow transplantation is characterized by a prolonged period of humoral immunodeficiency in which many patients have abnormal circulating B-cell subsets, and oligoclonal and monoclonal gammapathies. In this study we examine B-cell precursor reconstitution in the post-transplantation marrow. Within 1 month after transplantation there is a marked increase in the percentage of immature B cells (to 80% of marrow lymphocytes), which can persist for more than 1 year. The increase in B-cell precursors is seen in both adults and children and appears to be independent of age. These cells have a normal precursor B-cell surface antigenic phenotype (CD19+, CD10+, CD20 negative to dim) and generally express very little CD34. No monoclonal or oligoclonal immunoglobulin gene rearrangements are detected in these cells, which enables them to be easily distinguishable from common precursor B-cell acute lymphocytic leukemia lymphoblasts.
Modulatory activity of 2',2'-difluorodeoxycytidine on the phosphorylation and cytotoxicity of arabinosyl nucleosides. (1990)

This investigation analyzed the metabolism of 2',2'-difluorodeoxycytidine (dFdC) in K562 human leukemia cells and evaluated it as a biochemical modulator for the phosphorylation of several arabinosyl nucleosides. The rate of accumulation of dFdC triphosphate was linear up to 3 h and maximal during incubation with 10 microM dFdC (92 microM/h). Deoxynucleotides analyzed at this time showed a decrease in dCTP, dATP, and dGTP levels, indicating an inhibitory role of dFdC nucleotides in ribonucleotide reduction. We evaluated the hypothesis that dFdC-mediated deoxyribonucleoside triphosphate perturbation enhances the phosphorylation of substrates that use deoxycytidine kinase or deoxyguanosine kinase, because these enzymes are inhibited by dCTP or dGTP, respectively. When the activity of these nucleoside kinases was rate limiting to triphosphate formation, the accumulation of triphosphates of deoxycytidine, 1-beta-D-arabinofuranosylcytosine, and 1-beta-D-arabinofuranosylguanine was potentiated in cells pretreated with dFdC. In contrast, the phosphorylation of 9-beta-D-arabinofuranosyladenine was not affected, since it is mainly phosphorylated by adenosine kinase, which is not influenced by deoxyribonucleoside triphosphates. Treatment of cells with dFdC followed by 1-beta-D-arabinofuranosylcytosine resulted in greater cytotoxicity than sum effects of each drug alone. The data indicate that an enhanced cytotoxicity could be obtained by administering dFdC as a modulator followed by 1-beta-D-arabinofuranosylcytosine or 1-beta-D-arabinofuranosylguanine in optimal sequence, suggesting that these results should be considered in the design of combination clinical protocols.
Incremental decentralized diagnosis approach for the supervision of a telecommunication network (2003)

This paper extends the decentralized approach proposed by Pencole (2000) for diagnosing discrete-event systems. The incrementality issue, which is a crucial point in the context of online diagnosis, is discussed and two solutions are proposed.
Playing it safe (2004)

We have presented a new actuation concept for human-friendly robot design, referred to as DM/sup 2/. The new concept of DM/sup 2/ was demonstrated on a two-degree-of-freedom prototype robot arm that we designed and built to validate our approach. The new actuation approach substantially reduces the impact loads associated with uncontrolled manipulator collision by relocating the major source of actuation effort from the joint to the base of the manipulator. The emerging field of human-centered robotics focuses on application such as medical robotics and service robotics, which require close interaction between robotic manipulation systems and human beings, including direct human-manipulator contact. As a result, this system must consider the requirements of safety. To achieve safety we must employ multiple strategies involving all aspects of manipulator design.
Ionophore activity of sarcotoxin I, a bactericidal protein of <i>Sarcophaga peregrina</i> (1985)

When Escherichia coli was treated with sarcotoxin I, a potent bactericidal protein of Sarcophaga peregrina (fleshfly), K+ inside of the cells leaked out rapidly and the ATP pool of the cells rapidly decreased. These results suggested that the bactericidal effect of sarcotoxin I was due to its ionophore activity, and that it blocked the generation of ATP by inhibiting formation of the proton gradient essential for oxidative phosphorylation. This was confirmed by use of an uncA mutant, which was much less susceptible than the wild-type strain to sarcotoxin I under fixed ionic conditions.
Hybrid light-emitting diodes from anthracene-contained polymer and CdSe/ZnS core/shell quantum dots (2014)

In this paper, we added CdSe/ZnS core/shell quantum dots (QDs) into anthracene-contained polymer. The photoluminescent (PL) characteristic of polymer/QD composite film could identify the energy transitions of anthracene-contained polymer and QDs. Furthermore, the electroluminescent (EL) characteristic of hybrid LED also identifies emission peaks of blue polymer and QDs. The maximum luminescence of the device is 970 cd/m(2) with 9.1 wt.% QD hybrid emitter. The maximum luminous efficiency is 2.08 cd/A for the same device.
Functional organization of mammalian mitochondrial DNA in nucleoids: History, recent developments, and future challenges (2009)

Various proteins involved in replication, repair, and the structural organization of mitochondrial DNA (mtDNA) have been characterized in detail over the past 25 or so years. In addition, in recent years, many proteins were identified with a role in the dynamics of the mitochondrial network. Using advanced imaging and an increasing number of cytological techniques, we have begun to realize that an important aspect to mtDNA maintenance, in both health and disease, is its organization within the dynamic mitochondrial network in discrete protein-DNA complexes usually termed nucleoids. Here, I review recent developments in the study of nucleoid dynamics and proteins. I will discuss the implications of the organization of mtDNA in nucleoids in light of DNA replication, repair, gene expression, segregation, and inheritance.
National and state policies affecting learning expectations (1996)

Abstract Policies being articulated beyond the campus indicate what society expects undergraduates to learn.
Malt sprout extract medium for cultivation of Lactobacillus plantarum protective cultures (2004)

When compared with MRS, the MSE medium cultures produced equal growth yields of Lact. plantarum VTT E-79098 and enhanced antimicrobial potential against the Gram-negative bacterium P. agglomerans and a Fusarium fungus. The MSE medium can be used as a low-cost alternative to MRS for producing high cell yields and good antimicrobial activity of Lact. plantarum.
Chronic Kidney Disease (2015)

This issue provides a clinical overview of chronic kidney disease, focusing on prevention, diagnosis, treatment, and patient information. The content of In the Clinic is drawn from the clinical information and education resources of the American College of Physicians (ACP), including ACP Smart Medicine and MKSAP (Medical Knowledge and Self-Assessment Program). Annals of Internal Medicine editors develop In the Clinic from these primary sources in collaboration with the ACP's Medical Education and Publishing divisions and with the assistance of science writers and physician writers. Editorial consultants from ACP Smart Medicine and MKSAP provide expert review of the content. Readers who are interested in these primary resources for more detail can consult http://smartmedicine.acponline.org, http://mksap.acponline.org, and other resources referenced in each issue of In the Clinic.
The Multiple Roles of Imidazolium Ionic Liquids in Transition‐Metal Catalysis: The Palladium‐Catalyzed Telomerization of 1,3‐Butadiene with Acetic Acid (2015)

Abstract The telomerization of 1,3‐butadiene with acetic acid catalyzed by palladium(II) acetate associated with a series of phosphines in 3‐(2‐methoxyethyl)‐1‐methylimidazolium acetate was used to investigate the role of the ionic liquid. The ionic liquid plays multiple roles in this reaction as it acts as the solvent, stabilizer, ligand, and cocatalyst. The reaction performed in the presence of Dan2phos, a trifluoromethylated sulfonated triarylphosphine, at 100 °C for 24 h gave a turnover number of 14 600 with 89 % selectivity to telomers at 75 % 1,3‐butadiene conversion and complete acetic acid conversion.