gebhart/patrepeval huggingface dataset:
Immortalization by truncated myc or ras genes and synergism between myc and ras genes in cell transformation. (1989)

Human c-myc and normal or mutant T24 H-ras1 genes either linked to the regulatory sequences of the human metallothionein IIa gene or unlinked have been employed individually or in combination to transfect early passage Chinese hamster lung cells. Since the c-myc and H-ras1 genes are present in recombinant plasmids carrying the aminoglycoside phosphotransferase (aph), gene transfectants were selected in the presence of geneticin. A synergistic effect has been observed between myc and H-ras1 genes in measurement of both the number of geneticin resistant colonies obtained and the parameters of morphological transformation and anchorage independence. Out study also demonstrates the ability of truncated myc and ras genes to induce immortalization of hamster cells.
Aza‐ und Thia‐2‐germa(II)‐indane und entsprechende 2,2′‐Spirobi(2‐germaindane) (1989)

Abstract Umsetzungen von dilithiiertem 1,2‐Phenylendiamin, N,N′‐Dimethylphenylendiamin, 1,2‐Dimercaptobenzol, 3,4‐Dimercaptotoluol und N‐Methyl‐2‐aminothiophenol mit dem Germaniumdichlorid‐Dioxan‐Komplex führen zu cyclischen Germylenen vom Germaindantyp ( 1–5 ). Als Nebenprodukte (durch Erhitzen) entstehen aus diesen Germylenen entsprechende 2,2′‐Spirobi(2‐germaindane) ( 6–9 ). Die Verbindungen sind analytisch sowie Massen‐ und NMR ( 1 H, 13 C) spektroskopisch charakterisiert. Von 7 liegt eine Röntgenstrukturanalyse vor.
Synthese und Stabilisierung von (Benzoyl-und Pentafluorbenzoyloxy)diphenylphosphan und Vergleich mit den entsprechenden isomeren Aroyldiphenylphosphanoxiden / Synthesis and Stabilization of (Benzoyl-and Pentafluorobenzoyloxy)diphenylphosphane and Comparison with the Corresponding Isomeric Aroyldiphenylphosphane Oxides (1981)

Abstract (Benzoyloxy)-and (pentafluorobenzoyloxy)diphenylphosphanes RC(O)OPPh 2 (2a, b) [R = C 6 H 5 (a), C 6 F 5 (b)] can be obtained by reaction of ClPPh 2 (1) with NaO 2 CC 6 H 5 and AgO 2 CCeF 5 , respectively [eq. (1)]. Oxidation of 2a with molecular oxygen yields (benzoyl-oxy)diphenylphosphane oxide (3a) [eq. (2)]. The complexes (OC) 5 CrPPh 2 OC(O)R (5a, b) are formed by the action of Na 2 OCC 6 H 5 and AgO 2 CC 6 F 5 , respectively on (OC) 5 CrPPh 2 Cl (4) [eq. (3)]. The chemical and spectroscopical properties of the (aroyloxy)diphenylphosphanes (2 a, b) are compared with the corresponding aryldiphenylphosphane oxides.
Chemogenomic profiling predicts antifungal synergies (2009)

Chemotherapies, HIV infections, and treatments to block organ transplant rejection are creating a population of immunocompromised individuals at serious risk of systemic fungal infections. Since single-agent therapies are susceptible to failure due to either inherent or acquired resistance, alternative therapeutic approaches such as multi-agent therapies are needed. We have developed a bioinformatics-driven approach that efficiently predicts compound synergy for such combinatorial therapies. The approach uses chemogenomic profiles in order to identify compound profiles that have a statistically significant degree of similarity to a fluconazole profile. The compounds identified were then experimentally verified to be synergistic with fluconazole and with each other, in both Saccharomyces cerevisiae and the fungal pathogen Candida albicans. Our method is therefore capable of accurately predicting compound synergy to aid the development of combinatorial antifungal therapies.
Abstract 3808: Novel compound conferring selectivity for cancer cells (2016)

Abstract There is a need to develop novel compounds that can effectively treat a broad range of cancers on their own, or in combination with approved therapies. As personalized medicine is developed, combinatorial approaches will become more common making it crucial to increase the repertoire of available drugs. In the past, drugs often were developed to target a biologically-relevant molecule, but structural limitations, stability and solubility issues, or lack of selectivity have hindered the clinical use of many of these drugs. Our approach was to first find a ‘high-quality’ compound that is selective for cancer cells, then characterize its mechanism of action and identify its target. High throughput screening (HTS) helped to rapidly identify a subset of compounds with selective toxicity toward MCF-7 (breast cancer) cells. Some of these compounds were further tested for their efficacy in HeLa (cervical cancer) cells, and we found one that selectively causes mitotic arrest at 250 nM in comparison to non-cancerous HFF-1 (foreskin fibroblast) cells. At 200 nM, this compound synergizes with drugs known to affect microtubule dynamics and cause mitotic arrest including Nocodazole and Paclitaxel (currently in use as an anti-cancer drug), causing them to be more effective at lower concentrations. Excitingly, this compound also provides a shielding effect for HFF-1 cells treated with Paclitaxel. To learn the mechanism of action for this compound, we performed immunofluorescence microscopy on HeLa and HFF-1 cells treated with a range of concentrations. We found that the mitotic spindle is improperly organized in HeLa cells at 250 nM, but not in HFF-1 cells. Interestingly, microtubules are completely gone in mitotic HeLa cells and are reduced in mitotic HFF-1 cells treated with &gt;500 nM. Given that this compound synergizes with drugs that directly bind to tubulin subunits to modify their dynamics of assembly and disassembly, and differently affects cancerous vs. healthy cells, we hypothesize that it has a unique mechanism of action and may affect microtubule nucleation. We are continuing to characterize the compound, and will identify its molecular target. In addition, we are generating further iterations to explore the Structure-Activity Relationship, and optimize its efficacy. Our in vitro data shows that our approach has the potential to identify novel compounds with the potential for therapeutic use. Citation Format: Dilan B. Jaunky, Pat Forgione, Alisa Piekny. Novel compound conferring selectivity for cancer cells. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 3808.
Aluminum Ions Induce Oat Protoplasts to Produce an Extracellular (1→3)β-d-Glucan (1990)

Aluminum chloride induced mesophyll protoplasts of oat (Avena sativa) to produce an extracellular polysaccharide (EPS). EPS induced by AlCl(3) appeared identical to that produced in response to the phytotoxin victorin (JD Walton, ED Earle [1985] Planta 165: 407-415). Al ions at 1 millimolar were toxic to protoplasts, but maximum EPS production occurred at a sublethal concentration of 200 micromolar, assayed at pH 6.0. As measured by incorporation of [(14)C]glucose, AlCl(3) stimulated EPS production 10- to 15- fold. Pretreatment of protoplasts with cycloheximide prevented EPS production but not cell death in response to AlCl(3), indicating that protein synthesis was necessary for EPS production but not for the phytotoxicity of Al ions. The trivalent salts of Y, Yb, Gd, and In also induced EPS production but those of Sc, Fe, Ga, Cr, and La did not. Mesophyll protoplasts from an acid-soil tolerant oat cultivar, Coker 83-23, produced less EPS in response to AlCl(3) than the acid-soil sensitive cultivar Fla 501. EPS was also produced by wheat (Triticum aestivum) and barley (Hordeum vulgare) protoplasts in response to AlCl(3). An Al-tolerant cultivar of wheat, Atlas, produced less EPS than an Al-sensitive cultivar, Scout, but an Al-tolerant cultivar of barley, Dayton, produced more than the Al-sensitive cultivar Kearney. Therefore, production of EPS by protoplasts in response to Al ions did not appear to be related to Al ion tolerance at the level of whole plants. EPS fluoresced in the presence of Calcofluor and Sirofluor and was degraded by purified laminarinase [(1-->3)beta-d-glucanase] but not pectinase (polygalacturonase). EPS was composed solely of glucose in 1-->3 linkages; hence it is a (1-->3)beta-d-glucan (callose).
Effects of Osmotic Water Stress and Gibberellic Acid on Initial Growth of Oak Seedlings (1973)

Red and white oak seeds were treated and untreated with gibberellic acid (GA) and then watered with graded polyethylene glycol 400 solutions to simulate various soil water stress conditions. Seedling growth decreased as the osmotic potential of the soil solution decreased from −1/3 bars to −4 bars to −8 bars (the low, moderate, and high osmotic stress conditions, respectively). Seedling dry weights at high stress condition averaged only 11% of seedling dry weights at low stress condition. At high stress condition, shoot growth was more suppressed than root growth. White oak roots grew somewhat better than red oak roots at high stress condition.Treatment of seed with GA prior to germination stimulated stem elongation and number of leaves per plant but inhibited formation of lateral roots and other aspects of shoot and root growth, especially among white oak seedlings. The GA-stimulated stem growth observed at the low stress condition was completely suppressed at moderate and high stress conditions. GA-white oak seedlings appeared to be less tolerant of soil stress than untreated seedlings.
Smooth Bosch Etch for Improved Si Diodes (2013)

A modified Bosch process is used to reduce leakage current resulting from surface damage and roughness for high aspect ratio pillars fabricated from Si p-i-n structures. C <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> F <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">8</sub> is used during both the etch and passivation steps to achieve a scallop-free and vertical structure. A 5× decrease in both the reverse bias leakage current and corresponding improvement in effective carrier density, charge density, depletion width, and minority carrier lifetime are observed using this process, indicating that surface charge states are decreased using this process. This can impact a number of 3-D next-generation devices.
Structure and physicochemistry of anodic oxide films on titanium and TA6V alloy (1999)

Anodization of titanium and its alloys is an important surface treatment, especially for adhesion applications, but is not as well studied as for aluminium alloys. This paper deals with the morphological, structural and physicochemical characterization of anodic oxide films grown on titanium and Ti–6Al–4V (TA6V) in chromic acid solution without (CA) or with (CA/HF) hydrofluoric acid addition. Several investigations methods are used: high-resolution scanning electron microscopy (HR-SEM), reflection high-energy electron diffraction (RHEED), x-ray photoelectron spectroscopy (XPS), secondary ion mass spectrometry (SIMS), nuclear reaction analysis (NRA) and wetting angle measurements. The occurrence and morphology of the nanoporous structure for CA/HF anodization are described. The compact films grown in CA solution are amorphous and the porous films grown in the CA/HF solution are partially crystalline. The thickness and morphology of the films are described and discussed as a function of the anodizing conditions and of the composition of the underlying substrate. The composition of the film appears to be TiO2+Al2O3 (with Ti/Al atomic ratio ∽5), with incorporation of fluorine from the solution in the porous films and of small quantities of vanadium in the films that are grown. The specific role played by the Cr(VI) and F species on the film growth-and-dissolution formation process is discussed and a growth mechanism is proposed. Copyright © 1999 John Wiley & Sons, Ltd.
Tandem mass spectrometry: structural and stereochemical information from steroids (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTandem mass spectrometry: structural and stereochemical information from steroidsMichael T. Cheng, Michael P. Barbalas, Robert F. Pegues, and Fred W. McLaffertyCite this: J. Am. Chem. Soc. 1983, 105, 6, 1510–1513Publication Date (Print):March 1, 1983Publication History Published online1 May 2002Published inissue 1 March 1983https://pubs.acs.org/doi/10.1021/ja00344a017https://doi.org/10.1021/ja00344a017research-articleACS PublicationsRequest reuse permissionsArticle Views158Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
LPC interpolation by approximation of the sample autocorrelation function (1998)

Conventionally, the energy of analysis frames is not taken into account for linear prediction (LPC) interpolation. Incorporating the frame energy improves the subjective quality of interpolation, but increases the spectral distortion (SP). The main reason for this discrepancy is that the outliers are increased in low energy parts of segments with rapid changes in energy. The energy is most naturally combined with a normalized autocorrelation representation.
Betting Against the Glass Ceiling: Supervisor Gender & Employee Job Satisfaction in the Casino-Entertainment Industry (2014)

This exploratory study expands on hospitality management literature, specifically on the influence of a supervisor’s gender in regards to employee job satisfaction within the casino-entertainment sector. Employee job satisfaction was analyzed using company, department, and supervisor variables based on 961 surveys. The study’s results suggest that employees with male supervisors have a higher employee satisfaction level than employees with supervisors that are female. Hospitality organizations are therefore encouraged to create leadership programs to ensure women are a part of corporate leadership’s success formula for the future.
The acute effects of <scp>L</scp>‐theanine in comparison with alprazolam on anticipatory anxiety in humans (2004)

L-Theanine (delta-glutamylethylamide) is one of the predominant amino acids ordinarily found in green tea, and historically has been used as a relaxing agent. The current study examined the acute effects of L-theanine in comparison with a standard benzodiazepine anxiolytic, alprazolam and placebo on behavioural measures of anxiety in healthy human subjects using the model of anticipatory anxiety (AA). Sixteen healthy volunteers received alprazolam (1 mg), L-theanine (200 mg) or placebo in a double-blind placebo-controlled repeated measures design. The acute effects of alprazolam and L-theanine were assessed under a relaxed and experimentally induced anxiety condition. Subjective self-reports of anxiety including BAI, VAMS, STAI state anxiety, were obtained during both task conditions at pre- and post-drug administrations. The results showed some evidence for relaxing effects of L-theanine during the baseline condition on the tranquil-troubled subscale of the VAMS. Alprazolam did not exert any anxiolytic effects in comparison with the placebo on any of the measures during the relaxed state. Neither L-theanine nor alprazalam had any significant anxiolytic effects during the experimentally induced anxiety state. The findings suggest that while L-theanine may have some relaxing effects under resting conditions, neither L-theanine not alprazolam demonstrate any acute anxiolytic effects under conditions of increased anxiety in the AA model.
Neutropenia in Human Immunodeficiency Virus Infection (2006)

Worsening HIV disease parameters are associated with neutropenia in HIV-infected women. Treatment with HAART, without zidovudine in the regimen, protects against development of neutropenia, whereas HAART use and higher CD4 cell counts are associated with resolution of neutropenia. Neutropenia is not associated with decreased survival in HIV-infected women.
Synthesis of Highly Monodispersed Core/Shell Mesoporous Silica Spheres (2006)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Asymmetric Synthesis of (+)-Phosphinothricin and Related Compounds by the Michael Addition of Glycine Schiff Bases to Vinyl Compounds (1987)

Abstract (S)-(+)-Phosphinothricin was prepared in good optical yield by the Michael addition of chiral glycine Schiff base derived from (S)-2-hydroxy-3-pinanone to vinyl phosphorus compound. (R)-(−)-Phosphinothricin, an enantiomeric isomer, can also be prepared from the same chiral glycine Schiff base by choosing suitable reaction temperature.
Comparison of Double and Triple High‐Dose Chemotherapy with Autologous Blood Stem Cell Transplantation in Patients with Metastatic Breast Cancer (2001)

In patients with metastatic breast cancer (MBC), early dose intensification with multiple cycles of peripheral blood stem cell-supported high-dose chemotherapy (HDCT) seems superior to a late dose-intensification strategy. We compared the progression-free survival (PFS) and overall survival (OS) of 20 patients treated with a double (D)-HDCT regimen to 20 patients who received a triple (T)-HDCT, matched by age, estrogen receptor (ER) status, adjuvant chemotherapy, initial disease-free interval, predominant metastatic site, and number of metastatic sites. At a median follow-up of 41.5 months (range, 14-88 months) an intent-to-treat analysis showed no difference in PFS (p = 0.72) and OS (p = 0.93) between the matched patients. For all 76 patients treated within the D- or T-HDCT trial, median PFS and OS was 13 months (range, 2-78 months) and 24.5 months (range, 7-78 months), respectively. In multivariate analysis independent predictors of shorter OS included negative ER (relative risk [RR] = 3.0 [95% confidence interval (CI) 1.5-5.9]; p = 0.002), more than two metastatic sites (RR = 2.4 [95% CI 1.0-5.7]; p = 0.049) and failure to achieve complete remission/no evidence of disease (CR/NED) after HDCT (RR = 4.5 [95% CI 2.0-10.1]; p < 0.0001). These data show that early dose intensification with T-HDCT is not superior to a D-HDCT regimen in patients with MBC. ER-negative tumors, more than two metastatic sites and no CR/NED after HDCT, are associated with inferior outcome.
Application of fiber Bragg grating sensors in light aircraft: ground and flight test (2014)

Fiber optic sensors are being spotlighted as the means to monitoring aircraft conditions due to their excellent characteristics. This paper presents an affordable structural health monitoring system based on a fiber Bragg grating sensor (FBG) for application in light aircrafts. A total of 24 FBG sensors were installed in the main wing of the test bed aircraft. In the ground test, the intactness of the installed sensors and device operability were confirmed. During the flight test, the strain and temperature responses of the wing structure were measured by the on-board low-speed FBG interrogator. The measured strains were successfully converted into the flight load history through the load calibration coefficient obtained from the ground calibration test.
Imidazopyridinium and Pyridopyrimidium Bromides:  Synthesis and Hydrolysis (2002)

The reactions of symmetrical and unsymmetrical 2,2‘-dipyridylamines with 1,2-dibromoethane and 1,3-dibromopropane give imidazopyridinium and pyridopyrimidium bromides, respectively. These acetone/CH2Cl2-insoluble, highly fluorescent quaternary ammonium salts undergo addition/ring opening upon treatment with methanolic KOH to give pyridin-2-one derivatives. A sequential N,N-dialkylation/ring-opening hydrolysis/N,N-dialkylation/ring-opening hydrolysis strategy was developed for the construction of unsymmetrical bis(pyridin-2-ones).
Learning human activities and object affordances from RGB-D videos (2013)

Understanding human activities and object affordances are two very important skills, especially for personal robots which operate in human environments. In this work, we consider the problem of extracting a descriptive labeling of the sequence of sub-activities being performed by a human, and more importantly, of their interactions with the objects in the form of associated affordances. Given a RGB-D video, we jointly model the human activities and object affordances as a Markov random field where the nodes represent objects and sub-activities, and the edges represent the relationships between object affordances, their relations with sub-activities, and their evolution over time. We formulate the learning problem using a structural support vector machine (SSVM) approach, where labelings over various alternate temporal segmentations are considered as latent variables. We tested our method on a challenging dataset comprising 120 activity videos collected from 4 subjects, and obtained an accuracy of 79.4% for affordance, 63.4% for sub-activity and 75.0% for high-level activity labeling. We then demonstrate the use of such descriptive labeling in performing assistive tasks by a PR2 robot.
Is There A Minimum Size and a Maximum Speed for a Nanoscale Amplifier? (1998)

ABSTRACT: The C 60 electromechanical amplifier is a working 3‐terminal device based on the modulation of the tunnel‐transport regime through a C 60 molecule by a reversible deformation of its cage. We present the advantages of the planarization of this triode such as a surface extension lower than 0.05μm 2 on the wafer and a large gain ( G d > 40). High‐speed operation (bandwidth greater than 1 GHz) and low energy dissipation in the attojoules range are discussed together with the technological difficulties to fabricate such a planar molecular triode.
Evolution of a microlens surface under etching conditions (1993)

This paper discusses the effects of an etching process on the optical figure of a microlens transferred from photoresist to an underlying substrate. I state a general equation for the evolution of a surface under etching conditions. I then show how isotropic and anisotropic etching conditions behave within this surface evolution theory. I demonstrate how ion milling is not an anisotropic process when eroding 3-D surfaces. Finally, I show that this behavior leads to aberrations in microlenses when subjected to ion milling as a pattern transfer technique.
Inverse halftoning of scanned images (2002)

Our goal in this research is to find a good inverse halftoning algorithm that recovers gray-scale images from the scanned images. To this aim, we develop the printer and the scanner models and two types of reconstruction methods. In the first method, the reconstruction filter is derived directly from the scanned data and the ideal original gray-scale image. In the second method, the forward halftoning, the printing and the scanning processes are reversed one by one. Either approach seems to produce reasonably good results.