gebhart/patrepeval huggingface dataset:
Ovariectomy is sufficient to accelerate spontaneous skin ageing and to stimulate ultraviolet irradiation-induced photoageing of murine skin (2004)

These results suggest that ovariectomy alone is sufficient to accelerate skin ageing and to increase UV sensitivity, which results in the further deterioration of the skin and photoageing, and may account for the accelerated skin ageing seen in postmenopausal women.
Differentially expressed protein Pdcd4 inhibits tumor promoter-induced neoplastic transformation (1999)

An mRNA differential display comparison of mouse JB6 promotion-sensitive (P+) and -resistant (P-) cells identified a novel gene product that inhibits neoplastic transformation. The JB6 P+ and P- cells are genetic variants that differ in their transformation response to tumor promoters; P+ cells form anchorage-independent colonies that are tumorigenic, and P- cells do not. A differentially displayed fragment, A7-1, was preferentially expressed in P- cells at levels >/=10-fold those in P+ cells, making its mRNA a candidate inhibitor of neoplastic transformation. An A7-1 cDNA was isolated that was identical to murine Pdcd4 gene cDNAs, also known as MA-3 or TIS, and analogous to human H731 and 197/15a. Until now, the function of the Pdcd4 protein has been unknown. Paralleling the mRNA levels, Pdcd4 protein levels were greater in P- than in P+ cells. Pdcd4 mRNA was also expressed at greater levels in the less progressed keratinocytes of another mouse skin neoplastic progression series. To test the hypothesis that Pdcd4 inhibits tumor promoter-induced transformation, stable cell lines expressing antisense Pdcd4 were generated from parental P- cells. The reduction of Pdcd4 proteins in antisense lines was accompanied by acquisition of a transformation-sensitive (P+) phenotype. The antisense-transfected cells were reverted to their initial P- phenotype by overexpression of a Pdcd4 sense fragment. These observations demonstrate that the Pdcd4 protein inhibits neoplastic transformation.
Regulation of the Embryonic Morphogen Nodal by Notch4 Facilitates Manifestation of the Aggressive Melanoma Phenotype (2010)

Metastatic melanoma is an aggressive skin cancer associated with poor prognosis. The reactivation of the embryonic morphogen Nodal in metastatic melanoma has previously been shown to regulate the aggressive behavior of these tumor cells. During the establishment of left-right asymmetry in early vertebrate development, Nodal expression is specifically regulated by a Notch signaling pathway. We hypothesize that a similar relationship between Notch and Nodal may be reestablished in melanoma. In this study, we investigate whether cross talk between the Notch and Nodal pathways can explain the reactivation of Nodal in aggressive metastatic melanoma cells. We show a molecular link between Notch and Nodal signaling in the aggressive melanoma cell line MV3 via the activity of an RBPJ-dependent Nodal enhancer element. We show a precise correlation between Notch4 and Nodal expression in multiple aggressive cell lines but not poorly aggressive cell lines. Surprisingly, Notch4 is specifically required for expression of Nodal in aggressive cells and plays a vital role both in the balance of cell growth and in the regulation of the aggressive phenotype. In addition, Notch4 function in vasculogenic mimicry and anchorage-independent growth in vitro is due in part to Notch4 regulation of Nodal. This study identifies an important role for cross talk between Notch4 and Nodal in metastatic melanoma, placing Notch4 upstream of Nodal, and offers a potential molecular target for melanoma therapy.
A REVISION OF THE GUTMANN DONOR NUMBERS OF A SERIES OF PHOSPHORAMIDES INCLUDING TEPA (2015)

The donor numbers (DN) of a series of 20 phosphoramides with general structure (R2N)(X2N)(Y2N)P=O (with R,X and Y alkyl radicals, nitrogen-heterocycles or hydrogen atoms) were revised on the basis of a series of rather simple considerations. It is shown that all the phosphoramides considered even after the revision are characterized by high DN. In a scale of 163 different type of solvent molecules, the phosphoramides are all collocated with their DN above 35 Kcal/mol till 50 Kcal/mol. The extremely high DN value reported previously for TEPA, is now revised to 50 Kcal/mol. The highest DN values in the phosphoramides considered were found in (aziridino)3P=O (TEPA), (NHEt)3P=O and in (Pyrrolidino)3P=O.
Xpress Transport Protocol version 4 (2002)

The Xpress Transport Protocol (XTP) has been designed to support a variety of applications ranging from real-time embedded systems to multimedia distribution to applications distributed over a wide area network. In a single protocol it provides all the classic functionality of TCP, UDP, and TP4, plus new services such as transport multicast, multicast group management, transport layer priorities, traffic descriptions for quality-of-service negotiation, rate and burst control, and selectable error and flow control mechanisms. XTP has the same interconnectivity as TCP/UDP/TP4 because it operates over any network layer (IP, CLNP), any datalink layer (LLC, MAC), or directly on top of the AAL of ATM. In general, XTP avoids coupling policy with mechanism; XTP offers services but the user's application defines what communications paradigm is most appropriate for its particular environment. XTP is a high performance protocol, and can sustain high throughput (92 Mbits/s over FDDI between a pair of IBM RS/6000 model 370s) and low latency (350 /spl mu/s to move 100 bytes from user memory to user memory on two 50 MHz PCs connected by FDDI). Since XTP can run in parallel with all other transport protocols, and can run over whatever network layer (if any) is provided, it represents a low-risk way to exploit the increased functionality required for distributed applications without sacrificing connectedness or interoperability.
Crystallization sonification of high-dimensional datasets (2005)

This paper introduces Crystallization Sonification , a sonification model for exploratory analysis of high-dimensional datasets. The model is designed to provide information about the intrinsic data dimensionality (which is a local feature) and the global data dimensionality, as well as the transitions between a local and global view on a dataset. Furthermore the sound allows to display the clustering in high-dimensional datasets. The model defines a crystal growth process in the high-dimensional data-space which starts at a user selected “condensation nucleus” and incrementally includes neighboring data according to some growth criterion. The sound summarizes the temporal evolution of this crystal growth process. For introducing the model, a simple growth law is used. Other growth laws which are used in the context of hierarchical clustering are also suited and their application in crystallization sonification offers new ways to inspect the results of data clustering as an alternative to dendrogram plots. In this paper, the sonification model is described and example sonifications are presented for some synthetic high-dimensional datasets.
Common pigmentation disorders. (2009)

Common causes of hyperpigmentation include postinflammatory hyperpigmentation, melasma, solar lentigines, ephelides (freckles), and café-au-lait macules. Although most hyperpigmented lesions are benign and the diagnosis is straightforward, it is important to exclude melanoma and its precursors and to identify skin manifestations of systemic disease. Treatment options for postinflammatory hyperpigmentation, melasma, solar lentigines, and ephelides include the use of topical agents, chemical peels, cryotherapy, or laser therapy. Caf&-au-lait macules are amenable to surgical excision or laser treatment. Disorders of hypopigmentation may also pose diagnostic challenges, although those associated with health risks are uncommon and are usually congenital (e.g., albinism, piebaldism, tuberous sclerosis, hypomelanosis of Ito). Acquired disorders may include vitiligo, pityriasis alba, tinea versicolor, and postinflammatory hypopigmentation. Treatment of patients with widespread or generalized vitiligo may include cosmetic coverage, psoralen ultraviolet A-range therapy (with or without psoralens), or narrow-band ultraviolet-B therapy; whereas those with stable, limited disease may be candidates for surgical grafting techniques. Patients with extensive disease may be candidates for depigmentation therapy. Other acquired disorders may improve or resolve with treatment of the underlying condition.
Cinematized Reality: Cinematographic 3D Video System for Daily Life Using Multiple Outer/Inner Cameras (2006)

The purpose of Cinematized Reality is to record unexpected moments in people’s lives and create movies that look as if they were created from real, expertly captured film footage. The approach toward Cinematized Reality is to generate free-view video streams from multiple videos. The proposed system reconstructs 3D models of the capturing space using outer environmental cameras and an inner omni-directional camera, and then generates realistic video of those objects from a designated viewpoint by controlling a virtual camera as an expert would. This prototype system follows the grammar of film language and applies expert knowledge to generate desirable film footage using a sequence of shots taken by the virtual camera.
Scavenger receptor for aldehyde-modified proteins. (1986)

This paper describes an unexpectedly broad ligand specificity of a scavenger receptor of sinusoidal liver cells that is responsible for endocytic uptake of formaldehyde-treated bovine serum albumin (f-Alb). Binding of 125I-f-Alb to the isolated cells was effectively inhibited by bovine serum albumin (BSA) modified with aliphatic aldehydes such as glycolaldehye, DL-glyceraldehyde, and propionaldehyde whereas albumin preparations modified by aromatic aldehydes such as pyridoxal, pyridoxal phosphate, salicylaldehyde, and benzaldehyde did not affect this binding process. Binding of 125I-glycolaldehyde-treated BSA to the cells exhibited a saturation kinetics with an apparent Kd = 3.3 micrograms of the ligand/ml. This binding process was inhibited by unlabeled f-Alb as well as by the antibody raised against the f-Alb receptor. Indeed, 125I-glycolaldehyde-treated BSA underwent a rapid plasma clearance (t1/2 approximately 2 min) which was markedly retarded by unlabeled f-Alb. Upon treatment by these aldehydes, other proteins such as ovalbumin, soybean trypsin inhibitor, and hemoglobin were also converted to active ligands for the f-Alb receptor, while no ligand activity was generated with gamma-globulin and RNase A. These results clearly show that the f-Alb receptor, originally described as being specific for f-Alb, exhibits a broad ligand specificity in terms of both aldehydes and proteins and, hence, should be described as a scavenger receptor for aldehyde-modified proteins.
Synthesis and diuretic properties of some N-alkylaminocarbonyl- and N-pyrrolylcarbonylanthranilic acid derivatives (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and diuretic properties of some N-alkylaminocarbonyl- and N-pyrrolylcarbonylanthranilic acid derivativesArthur M. Felix, Leo B. Czyzewski, Donald P. Winter, and R. Ian FryerCite this: J. Med. Chem. 1969, 12, 3, 384–387Publication Date (Print):May 1, 1969Publication History Published online1 May 2002Published inissue 1 May 1969https://pubs.acs.org/doi/10.1021/jm00303a010https://doi.org/10.1021/jm00303a010research-articleACS PublicationsRequest reuse permissionsArticle Views71Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Targeting of Interleukin-6 for the Treatment of Rheumatoid Arthritis: A Review and Update (2014)

Rheumatoid Arthritis (RA) is a chronic inflammatory disease, characterized by persistent joint inflammation, systemic inflammation and immunological abnormalities. Since IL-6 plays a major role in the development of these characteristics, its targeting could reasonably be expected to constitute a novel therapeutic strategy for the treatment of RA. Tocilizumab, a humanized anti-human IL-6 receptor monoclonal antibody, has demonstrated its outstanding clinical efficacy and tolerable safety profile in phase III clinical trials for RA patients, resulting in its worldwide approval for moderate-to-severe active RA. Post-marketing clinical trials have confirmed its efficacy. This success led to the development of various other IL-6 inhibitors. Further clinical studies including head-to-head comparative studies, and clarification of the mechanisms through which tocilizumab exerts its clinical effects can be expected to identify RA patients who should be treated with tocilizumab as a first-line biologic. In addition, recent case reports and pilot studies indicate that therapies targeting IL-6 will be widely applicable to the treatment of various intractable immune-mediated diseases.
A novel control strategy of the inverter with sinusoidal voltage and current outputs (2002)

The authors have previously proposed a novel inverter with sinusoidal, voltage and current outputs (1992). In the novel inverter, the design of a high-pass filter inserted in the feedback circuit largely influences the output waveforms. In this paper, the authors show a solution to the design problem of the high-pass filter, applying a rotating coordinate transformation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Vaccination of BALB/c Mice with<i>Escherichia coli</i>-Expressed Vaccinia Virus Proteins A27L, B5R, and D8L Protects Mice from Lethal Vaccinia Virus Challenge (2008)

The potential threat of smallpox use in a bioterrorist attack has heightened the need to develop an effective smallpox vaccine for immunization of the general public. Vaccination with the current smallpox vaccine, Dryvax, produces protective immunity but may result in adverse reactions for some vaccinees. A subunit vaccine composed of protective vaccinia virus proteins should avoid the complications arising from live-virus vaccination and thus provide a safer alternative smallpox vaccine. In this study, we assessed the protective efficacy and immunogenicity of a multisubunit vaccine composed of the A27L and D8L proteins from the intracellular mature virus (IMV) form and the B5R protein from the extracellular enveloped virus (EEV) form of vaccinia virus. BALB/c mice were immunized with Escherichia coli-produced A27L, D8L, and B5R proteins in an adjuvant consisting of monophosphoryl lipid A and trehalose dicorynomycolate or in TiterMax Gold adjuvant. Following immunization, mice were either sacrificed for analysis of immune responses or lethally challenged by intranasal inoculation with vaccinia virus strain Western Reserve. We observed that three immunizations either with A27L, D8L, and B5R or with the A27L and B5R proteins alone induced potent neutralizing antibody responses and provided complete protection against lethal vaccinia virus challenge. Several linear B-cell epitopes within the three proteins were recognized by sera from the immunized mice. In addition, protein-specific cellular responses were detected in spleens of immunized mice by a gamma interferon enzyme-linked immunospot assay using peptides derived from each protein. Our data suggest that a subunit vaccine incorporating bacterially expressed IMV- and EEV-specific proteins can be effective in stimulating anti-vaccinia virus immune responses and providing protection against lethal virus challenge.
Blind identification of co-channel systems (2002)

One of the major impediments of reliable communication in systems employing frequency reusage is co-channel interference. In many cases, neither a training signal nor a priori measurements of the channel transfer functions are available. Hence, the receiver has to start up blindly. In this paper, we propose a new method for the blind identification of co-channel systems using higher-order statistics. Magnitude responses are estimated using the power spectrum of the received signal together with a slice of the bispectrum or the trispectrum. Then, phase responses are estimated using a slice of bispectrum or trispectrum only. Another approach based on cyclostationarity and different baud rates is also described.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The Metabolic Syndrome (2009)

The metabolic syndrome (MS) is a cluster of metabolic derangements that are associated with primary disturbances in adipose tissue. Abnormal visceral fat accumulates from physical inactivity and excess calories in genetically susceptible individuals. This increased adipocyte mass acts as an endocrine organ and communicates with other organ systems via increases in inflammatory cytokines. The resulting disorders define MS as increased waist circumference, decreased serum high-density lipoprotein, and increased serum triglyceride levels, hypertension, and insulin resistance. MS accounts for the majority of cardiovascular disease risk in the U.S. population. Dietary interventions, such as the Mediterranean diet, have been shown to improve these metabolic derangements. Many substances found in these diets are being investigated as specific therapies for MS, and when scientific substantiation is lacking, they may be considered as part of complementary and alternative medicine (CAM). However, as scientific evidence accumulates, these CAM treatments may become part of conventional medicine. This review will scrutinize the emerging evidence behind many, though not all, CAM treatments currently thought to target the various derangements found in MS.
Solid-State Amplified Spontaneous Emission in Some Spiro-Type Molecules: A New Concept for the Design of Solid-State Lasing Molecules (1998)

Spectral narrowing in amorphous molecular solid films of spiro-type molecules such as spiro-quarterphenyl (see Figure) is reported. It is demonstrated that introduction of the spiro linkage not only improves the processability and morphological properties but, for the molecules studied here, also suppresses concentration quenching, making these molecular solids attractive candidates for molecular solid-state lasers.
Banking Online For Dummies (1999)

This work helps readers discover their online banking options. Though bank Web sites around the world look different on the surface, they all offer the same underlying functionality. Here, readers should learn how to locate their bank online, review statements, check account balances, transfer funds, pay bills, communicate with the bank, and review product information, all online. Readers will also find out how to import their account information from the bank's Web site into their favourite financial software, whether that be Managing Your Money, Microsoft Money, AOL Bank Now, or QuickBooks. There is information on security issues, including tools, tips and government protection. It also covers how specific Web browsers can impact online banking functionality and what to do about it, along with a directory section filled with banking-related Web sites. The CD includes ISP software, browsers, demo versions of popular banking software packages, the Directory section in HTML format, and other tools for online banking.
Clustering and sharing incentives in BitTorrent systems (2007)

Peer-to-peer protocols play an increasingly instrumental role in Internet content distribution. It is therefore important to gain a complete understanding of how these protocols behave in practice and how their operating parameters affect overall system performance. This paper presents the first detailed experimental investigation of the peer selection strategy in the popular BitTorrent protocol. By observing more than 40 nodes in instrumented private torrents, we validate three protocol properties that, though believed to hold, have not been previously demonstrated experimentally: the clustering of similar-bandwidth peers, the effectiveness of BitTorrent's sharing incentives, and the peers' high uplink utilization. In addition, we observe that BitTorrent's modified choking algorithmin seed state provides uniform service to all peers, and that an underprovisioned initial seed leads to absence of peer clustering and less effective sharing incentives. Based on our results, we provide guidelines for seed provisioning by content providers, and discuss a tracker protocol extension that addresses an identified limitation of the protocol.
Optical Investigation on the Growth Process of GaAs during Migration-Enhanced Epitaxy (1989)

The growth process of GaAs is investigated using optical reflection during migration-enhanced epitaxy which is based on an alternate deposition of Ga atoms and As 4 molecules onto the growing surface. A linearly polarized laser light is irradiated at a 20° angle with respect to the (001)-oriented GaAs substrate surface. A 325-nm He-Cd laser light with polarization E vector perpendicular to the substrate surface is more efficiently reflected from Ga-stabilized surfaces than from As-stabilized surfaces. Thus, strong and persistent oscillation in reflection intensity is observed during the alternate deposition of Ga and As 4 . When the polarization E vector of the incident light is parallel to the growing surface, no oscillation is observed. These results imply that the observed optical reflection oscillation is related to the optical absorptions caused by an electronic transition in the As-stabilized surface which couples efficiently with light whose polarization vector is normal to the surface.
Comparative Study of Human Hematopoietic Cell Engraftment into Balb/c and C57BL/6 Strain of Rag‐2/Jak3 Double‐Deficient Mice (2011)

Immunodeficient mice are becoming invaluable tools in human stem cell and tumor research. In this study, we generated Rag-2/Jak3 double-deficient (Rag-2⁻/⁻Jak3⁻/⁻) mice with a C57/BL6 and Balb/c genetic background and compared the human lymphohematopoietic cell engraftment rate. Human cord blood-derived CD34+ hematopoietic stem cells were successfully engrafted into Balb/c Rag-2⁻/⁻Jak3⁻/⁻ mice; however, the engraftment rate was far lower in C57/BL6 Rag-2⁻/⁻Jak3⁻/⁻ mice. Transplantation of human peripheral blood mononuclear cells resulted in the same tendency. Thus, a Balb/c background offers superior engraftment capacity than a C57/BL6 background and provides an attractive model for human hematopoietic cell engraftment.