gebhart/patrepeval huggingface dataset:
Interactive Mobile 3D Graphics for on-the-go visualization and walkthroughs (2006)

Developing interactive 3D graphics for mobile Java applications is now a reality. Recently, the Mobile 3D Graphics (M3G) API (also known as JSR-184) was proposed to provide an efficient 3D graphics environment suitable for the J2ME platform. However, new services and applications using interactive 3D graphics, which have already achieved reasonable standards on the desktop, do not exist for resource-constrained handheld devices yet. In this work, a generic architecture for visualizing and navigating through 3D worlds in a mobile setting was designed and implemented. In particular, a 3D virtual tour application was developed based on the proposed architecture, where multiple mobile clients using M3G navigate through and interact with each other in a shared 3D space.
Identification of Anti-Plasmin Antibodies in the Antiphospholipid Syndrome That Inhibit Degradation of Fibrin (2004)

The combined presence of anti-phospholipid Ab (aPL) and thrombosis is recognized as the antiphospholipid syndrome (APS). The aPL represent a heterogeneous group of Ab that recognize various phospholipids (PL), PL-binding plasma proteins, and/or PL-protein complexes. Recently, we found the presence of antithrombin Ab in some APS patients and that some of these anti-thrombin Ab could inhibit thrombin inactivation by antithrombin. Considering that thrombin is homologous to plasmin, which dissolves fibrin, we hypothesize that some APS patients may have Ab that react with plasmin, and that some anti-plasmin Ab may interfere with the plasmin-mediated lysis of fibrin clots. To test this hypothesis, we searched for anti-plasmin Ab in APS patients and then studied those found for their effects on the fibrinolytic pathway. The results revealed that seven of 25 (28%) APS patients have IgG anti-plasmin Ab (using the mean OD plus 3 SD of 20 normal controls as the cutoff) and that six of six patient-derived IgG anti-thrombin mAb bind to plasmin with relative K(d) values ranging from 5.6 x 10(-8) to 1 x 10(-6) M. These K(d) values probably represent affinities in the higher ranges known for human IgG autoantibodies against protein autoantigens. Of these mAb, one could reduce the plasmin-mediated lysis of fibrin clots. These findings suggest that plasmin may be an important driving Ag for some aPL B cells in APS patients, and that the induced anti-plasmin Ab may act either directly, by binding to plasmin and inhibiting its fibrinolytic activity, or indirectly, by cross-reacting with other homologous proteins in the coagulation cascade to promote thrombosis.
Pulse Powered Circuits (1966)

Methods of operating standard switching circuits in a Pulsed Power Circuit (PPC) mode in order to reduce power consumption and system complexity are discussed. The PPC concept involves gating the power supply ''on'' for short clocked time intervals. An interesting feature of the system is that multiple power clocks allow multiple numbers to be stored in the same circuits simultaneously.
Grain size control in FePt thin films by Ar-ion etched Pt seed layers (2001)

A method to control the grain size of FePt Ll/sub 0/ thin films by means of an Ar-ion etched Pt seed is presented. The etching results in structures on the surface of the Pt seed layer, whose feature size can be controlled by etching time and ion energy. The grain size for 25 nm thick FePt films grown at 450/spl deg/C can be reduced from about 29 nm on as-grown seed layers to 15 nm with a reduced grain size dispersion on etched seed layers. The coercivity of these films changes from 2 kOe to 11 kOe, respectively. To reduce the coercivity to a range suitable for writing with currently available recording heads, i.e., <4 kOe, up to 15 at.% Cr was added to the FePt alloy.
Modification of hemoglobin--ring opened dials. (1983)

The dialdehyde of ATP (o-ATP) has been synthesized and reacted with SFH. The conditions of reaction have been defined and the yields characterized. Close attention to the oxygenation state of SFH at the time of reaction is necessary; maintenance of the T-state is crucial as is low met-Hb concentrations. The o-ATP modified SFH has a near normal oxy-Hb affinity and a markedly prolonged, compared to SFH alone, intra-vascular retention. The effects of the modification on cooperativity and the specific binding sites are being evaluated. It appears that there is some loss of cooperativity by observation of the oxy-Hb dissociation curve.
Heat-shock protein-25/27 phosphorylation by the δ isoform of protein kinase C (1998)

Small heat-shock proteins (sHSPs) are widely expressed 25-28 kDa proteins whose functions are dynamically regulated by phosphorylation. While recent efforts have clearly delineated a stress-responsive p38 mitogen-activated protein-kinase (MAPK)-dependent kinase pathway culminating in activation of the heat-shock (HSP)-kinases, mitogen-activated protein-kinase-activated protein kinase-2 and -3, not all sHSP phosphorylation events can be explained by the p38 MAPK-dependent pathway. The contribution of protein kinase C (PKC) to sHSP phosphorylation was suggested by early studies but later questioned on the basis of the reported poor ability of purified PKC to phosphorylate sHSP in vitro. The current study re-evaluates the role of PKC in sHSP phosphorylation in the light of the isoform complexity of the PKC family. We evaluated the sHSP phosphorylation status in rat corpora lutea obtained from two stages of pregnancy, mid-pregnancy and late-pregnancy, which express different levels of the novel PKC isoform, PKC-delta. Two-dimensional Western blot analysis showed that HSP-27 was more highly phosphorylated in vivo in corpora lutea of late pregnancy, corresponding to the developmental stage in which PKC-delta is abundant and active. Late-pregnant luteal extracts contained a lipid-sensitive HSP-kinase activity which exactly co-purified with PKC-delta using hydroxyapatite and S-Sepharose column chromatography. To determine whether there might be preferential phosphorylation of sHSP by a particular PKC isoform, purified recombinant PKC isoforms corresponding to those PKC isoforms detected in rat corpora lutea were evaluated for HSP-kinase activity in vitro. Recombinant PKC-delta effectively catalysed the phosphorylation of sHSP in vitro, and PKC-alpha was 30-50% as effective as an HSP-kinase; other PKCs tested (beta1, beta2, epsilon and zeta) were poor HSP-kinases. These results show that select PKC family members can function as direct HSP-kinases in vitro. Moreover, the observation of enhanced luteal HSP-27 phosphorylation in vivo, in late pregnancy, when PKC-delta is abundant and active, suggests that select PKC family members contribute to sHSP phosphorylation events in vivo.
Modern Inorganic Chromatography (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTModern Inorganic ChromatographyHamish SmallCite this: Anal. Chem. 1983, 55, 2, 235A–242APublication Date (Print):February 1, 1983Publication History Published online29 May 2012Published inissue 1 February 1983https://pubs.acs.org/doi/10.1021/ac00253a787https://doi.org/10.1021/ac00253a787research-articleACS PublicationsRequest reuse permissionsArticle Views91Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Buried heterostructure lasers by silicon implanted, impurity induced disordering (1987)

Buried heterostructure lasers have been fabricated using impurity induced disordering from an implanted Si diffusion source. The diffused Si extends over 1 μm deep through the active region where the quantum wells are partially homogenized with the barrier and cladding layers to produce a lower refractive index and higher band-gap material. The resulting real refractive index waveguide exhibits single longitudinal and transverse mode behavior to greater than 20 mW for a 4-μm-wide waveguide.
Facial Expression Analysis using Active Shape Model (2015)

Facial expressions analysis is a vital part of the research in human-machine interaction.This chapter introduces an automatic recognition system for facial expression from a front view human face image.Obtaining an effective facial representation from initial face images is an essential phase for strong and efficient facial expression system.In this chapter we have developed a facial expression analysis system.Firstly we have tried to evaluate facial analysis base on Active shape model (ASM).In order to detect the face images, Adaboost classifier and Haar-Like feature has been adopted to achieve face detection and tracking.The ASM then has been automatically initiated in the detected face image.Then, discriminates and reliable facial feature points has been extracted applying ASM fitting technique.The geometric displacement among the projected ASM feature points coordinates and the mean shape of ASM were used to evaluate facial expression.Using support vector machine (SVM) classifier, the obtained results has reached a recognition rate of 93 %.
A new algorithm for hip fracture surgery (2012)

It is possible to implement an algorithm for treatment of all hip fracture patients in a large teaching hospital. In our case, the Hvidovre algorithm both raised the rate of supervision and reduced the rate of reoperations. The reduced reoperation rate saved many hospital bed-days.
Differential Network Analysis with Multiply Imputed Lipidomic Data (2015)

The importance of lipids for cell function and health has been widely recognized, e.g., a disorder in the lipid composition of cells has been related to atherosclerosis caused cardiovascular disease (CVD). Lipidomics analyses are characterized by large yet not a huge number of mutually correlated variables measured and their associations to outcomes are potentially of a complex nature. Differential network analysis provides a formal statistical method capable of inferential analysis to examine differences in network structures of the lipids under two biological conditions. It also guides us to identify potential relationships requiring further biological investigation. We provide a recipe to conduct permutation test on association scores resulted from partial least square regression with multiple imputed lipidomic data from the LUdwigshafen RIsk and Cardiovascular Health (LURIC) study, particularly paying attention to the left-censored missing values typical for a wide range of data sets in life sciences. Left-censored missing values are low-level concentrations that are known to exist somewhere between zero and a lower limit of quantification. To make full use of the LURIC data with the missing values, we utilize state of the art multiple imputation techniques and propose solutions to the challenges that incomplete data sets bring to differential network analysis. The customized network analysis helps us to understand the complexities of the underlying biological processes by identifying lipids and lipid classes that interact with each other, and by recognizing the most important differentially expressed lipids between two subgroups of coronary artery disease (CAD) patients, the patients that had a fatal CVD event and the ones who remained stable during two year follow-up.
Constitutive Phosphorylation of the Parkinson's Disease Associated α-Synuclein (2000)

alpha-Synuclein has been implicated in the pathogenesis of Parkinson's disease, since rare autosomal dominant mutations are associated with early onset of the disease and alpha-synuclein was found to be a major constituent of Lewy bodies. We have analyzed alpha-synuclein expression in transfected cell lines. In pulse-chase experiments alpha-synuclein appeared to be stable over long periods (t((1)/(2)) 54 h) and no endoproteolytic processing was observed. alpha-Synuclein was constitutively phosphorylated in human kidney 293 cells as well as in rat pheochromocytoma PC12 cells. In both cell lines phosphorylation was highly sensitive to phosphatases, since okadaic acid markedly stabilized phosphate incorporation. Phosphoamino acid analysis revealed that phosphorylation occurred predominantly on serine. Using site-directed mutagenesis we have identified a major phosphorylation site at serine 129 within the C-terminal domain of alpha-synuclein. An additional site, which was phosphorylated less efficiently, was mapped to serine 87. The major phosphorylation site was located within a consensus recognition sequence of casein kinase 1 (CK-1). In vitro experiments and two-dimensional phosphopeptide mapping provided further evidence that serine 129 was phosphorylated by CK-1 and CK-2. Moreover, phosphorylation of serine 129 was reduced in vivo upon inhibition of CK-1 or CK-2. These data demonstrate that alpha-synuclein is constitutively phosphorylated within its C terminus and may indicate that the function of alpha-synuclein is regulated by phosphorylation/dephosphorylation.
A Cloud-Based Virtual Reality App for a Novel Telemindfulness Service: Rationale, Design and Feasibility Evaluation (2017)

With such a small sample size, it is too early to make any specific conclusions, but the presented results may accelerate the use of innovative technologies and challenge new ideas in research and development in the field of mindfulness/telemindfulness.
Alienation, despair and hope as predictors of health, coping and nonengagement among nonengaged youth: manifestations of spiritual emptiness (2013)

In this research, nonengagement is conceived as a manifestation of spiritual emptiness characterized by alienation and despair. Three scales with satisfactory reliabilities, alienation, despair and hope, were developed and used as predictors of health, coping, and social and family nonengagement among 428 nonengaged youths (309 males and 119 females) aged 15–24 years in Hong Kong. The results show that alienation and despair are associated with (a) poorer health, (b) more frequent use of negative coping, especially by hiding oneself and, to a lesser extent, (c) nonengagement. Hope is associated with better health and more frequent use of positive coping. These results support the contention that nonengagement is a loss of hope, meaning and purpose in life.
Design criteria for ultrafast optical parametric amplifiers (2016)

Optical parametric amplifiers (OPAs) exploit second-order nonlinearity to transfer energy from a fixed frequency pump pulse to a variable frequency signal pulse, and represent an easy way of tuning over a broad range the frequency of an otherwise fixed femtosecond laser system. OPAs can also act as broadband amplifiers, transferring energy from a narrowband pump to a broadband signal and thus considerably shortening the duration of the pump pulse. Due to these unique properties, OPAs are nowadays ubiquitous in ultrafast laser laboratories, and are employed by many users, such as solid state physicists, atomic/molecular physicists, chemists and biologists, who are not experts in ultrafast optics. This tutorial paper aims at providing the non-specialist reader with a self-consistent guide to the physical foundations of OPAs, deriving the main equations describing their performance and discussing how they can be used to understand their most important working parameters (frequency tunability, bandwidth, pulse energy/repetition rate scalability, control over the carrier-envelope phase of the generated pulses). Based on this analysis, we derive practical design criteria for OPAs, showing how their performance depends on the type of the nonlinear interaction (crystal type, phase-matching configuration, crystal length), on the characteristics of the pump pulse (frequency, duration, energy, repetition rate) and on the OPA architecture.
Fatigue Life Assessment of Rolling Bearings Made from AISI 52100 Bearing Steel (2019)

The rolling bearings used in various industrial applications are exposed to fatigue failure during their operation. Generally, in a practical application, the ISO 281:2007 standard is used for fatigue life assessments of rolling bearings. The application of the formula given in this standard requires knowledge concerning the basic dynamic load rating <i>C</i>. The natural question is raised of whether it is possible to omit the time-consuming experimental tests while still effectively calculating the fatigue load or the load capacity of the bearings. In the paper, the authors propose the application of analytical formulas for stresses in the contact area and its vicinity, and the usage of the multiaxial high-cycle fatigue hypothesis to estimate the maximal fatigue load for the rolling bearings. In the proposed methodology, only the knowledge concerning the fatigue properties of the material and geometry characteristics of the analyzed bearings are demanded. The effectiveness of the authors' proposal is verified for arbitrarily chosen bearings. The observed discrepancy between the catalogue fatigue load (SKF catalogue) and numerically calculated fatigue load usually does not exceed 10%, which is fully acceptable from an engineering point of view and justifies the approach proposed in the paper. The proposed methodology can be used for the prediction of the fatigue life and optimization of the rolling bearings.
Glibenclamide and meglitinide block the transport of low molecular weight solutes into malaria‐infected erythrocytes (1993)

Following infection by the malaria parasite, human erythrocytes show increased uptake of a wide variety of low molecular weight solutes via pathways with functional characteristics different from those of the transporters of normal erythrocytes. In this study glibenclamide and meglitinide were shown to inhibit the induced transport of a sugar alcohol (sorbitol), an amino acid (threonine), an inorganic anion (Cl-) and an organic cation (choline) into human erythrocytes infected in vitro with Plasmodium falciparum. The results are consistent with the hypothesis that a diverse range of substrates enter malaria-infected cells via common pathways which have features in common with Cl- channels in other cell types. glibenclamide and meglitinide were also shown to inhibit the in vitro growth of the intracellular parasite which would suggest that these pathways may be a viable chemotherapeutic target.
Dynamic Web Service Composition: Challenges and techniques (2009)

One of the great challenges to be faced in order to enable the success of future Web-based applications is to find effective ways to handle with the interoperability demands. In this context, Service-Oriented Architectures and Web Services technology are being considered as the most affordable solution to promote interoperability, by applying strategies like Service Composition. Nevertheless, most composition approaches applied nowadays in real world contexts lack dynamism. In fact, there is not yet a consensus regarding what would really be a dynamic composition. In this paper we propose some criteria to identify the levels of dynamism and automatization in service compositions. Furthermore, taking into account a model driven approach, we propose a strategy where different techniques can be used to make compositions more dynamic and automatic. This strategy is then exemplified and discussed considering an e-Government composition scenario.
Organic bionics (2010)

Bionic technology involves the efficient integration of biology and electronics and is providing the basis for significant improvements in a number of medical treatments. The use of organic conducting polymers to provide a compatible multifunctional platform to interface the world of biology and electronics has attracted an increasing amount of attention over the past 15 years. This paper will discuss advances being made in the development of organic bionics and their application to improved health strategies.
Relevance and safety of telomerase for human tissue engineering (2006)

Tissue engineering holds the promise of replacing damaged or diseased tissues and organs. The use of autologous donor cells is often not feasible because of the limited replicative lifespan of cells, particularly those derived from elderly patients. Proliferative arrest can be overcome by the ectopic expression of telomerase via human telomerase reverse transcriptase (hTERT) gene transfection. To study the efficacy and safety of this potentially valuable technology, we used differentiated vascular smooth muscle cells (SMC) and vascular tissue engineering as a model system. Although we previously demonstrated that vessels engineered with telomerase-expressing SMC had improved mechanics over those grown with control cells, it is critical to assess the phenotypic impact of telomerase expression in donor cells, because telomerase up-regulation is observed in >95% of human malignancies. To study the impact of telomerase in tissue engineering, expression of hTERT was retrovirally induced in SMC from eight elderly patients and one young donor. In hTERT SMC, significant lifespan extension beyond that of control was achieved without population doubling time acceleration. Karyotype changes were seen in both control and hTERT SMC but were not clonal nor representative of cancerous change. hTERT cells also failed to show evidence of neoplastic transformation in functional assays of tumorigenicity. In addition, the impact of donor age on cellular behavior, particularly the synthetic capability of SMC, was not affected by hTERT expression. Hence, this tissue engineering model system highlights the impact of donor age on cellular synthetic function that appears to be independent of lifespan extension by hTERT.