gebhart/patrepeval huggingface dataset:
Integrating Object-Oriented Scripting Languages with HyTime (1994)

HyTime provides a comprehensive set of primitives for composing hypermedia documents, but does not provide facilities for representing interaction or dynamic behavior, areas which are required in commercial multimedia authoring environments. In previous work we have developed and implemented a prototype HyTime engine called HyOctane in which HyTime interactive multimedia documents can be stored and .retrieved. In this paper we extend this work to include scripting language facilities, an area currently not dealt with by the standard but which is crucial in order to represent interactive multimedia documents. We compare different approaches to integrating HyTime document type definitions with scripts and describe the extensions to our engine architecture ana‘ implementation status.
<i>Chimie Douce</i> Synthesis of Nanostructured Layered Materials (1996)

A class of layered ammonium transition-metal molybdate materials were derived by a novel room-temperature chimie douce synthesis technique using calcined layered double hydroxides (LDHs) as precursors. The compounds obtained are highly crystalline, and retain the rhombohedral symmetry of the LDH precursors. The host structure consists of distorted divalent cation octahedra which share edges to form layers perpendicular to the c axis, analogous to the LDH precursor. The tetrahedral molybdate species, however, are not merely intercalated within the interlayer domain, but are bonded to the layers themselves through shared Mo-O-M bonds, where M = Zn2+, Co2+, Cu2+, or Ni2+. This arrangement results in the formation of a net negative charge on the host structure, leading to incorporation of ammonium ions between the layers for charge balancing. The applicability of this novel synthesis route is dependent on the composition of the LDH precursor, and it appears that metastability in the calcined LDH favors conversion to this phase.
Electrodeposition and the properties of composite Zn + Ni coatings (2010)

Abstract Composite Zn + Ni coatings were obtained by electrodeposition of Zn with Ni particles on a steel substrate from a zinc chloride based electrolyte in which metallic Ni powder was suspended by mechanical stirring. The deposition was carried out under galvanostatic conditions. The effect of the metal powder amount in the bath, as well as the deposition current density, on the content of incorporated Ni particles in the coatings was investigated. The deposits have been characterized by the presence of Ni particles embedded into the crystalline Zn matrix. The mechanism of metallic particles' embedding was explained on the base of Zn 2+ ions adsorption process. The surface morphology of the obtained coatings was investigated by SEM method. The deposited composite coatings were subjected to the thermal treatment in order to carry out the reaction in the solid state between the zinc matrix and incorporated Ni particles and to reach the better homogeneity of the examined material. The corrosion resistance properties of Zn and Zn + Ni coatings in 5% NaCl solution were compared by examining the results acquired through Stern method and electrochemical scanning methods. The corrosion potential E corr , corrosion current density i corr and polarization resistance R p have been determined, as a measure of corrosion resistance. Copyright © 2010 John Wiley & Sons, Ltd.
Differential Power Processing for Increased Energy Production and Reliability of Photovoltaic Systems (2012)

Conventional energy conversion architectures in photovoltaic (PV) systems are often forced to tradeoff conversion efficiency and power production. This paper introduces an energy conversion approach that enables each PV element to operate at its maximum power point (MPP) while processing only a small fraction of the total power produced. This is accomplished by providing only the mismatch in the MPP current of a set of series-connected PV elements. Differential power processing increases overall conversion efficiency and overcomes the challenges associated with unmatched MPPs (due to partial shading, damage, manufacturing tolerances, etc.). Several differential power processing architectures are analyzed and compared with Monte Carlo simulations. Local control of the differential converters enables distributed protection and monitoring. Reliability analysis shows significantly increased overall system reliability. Simulation and experimental results are included to demonstrate the benefits of this approach at both the panel and subpanel level.
<scp>TMEM</scp>106B p.T185S regulates <scp>TMEM</scp>106B protein levels: implications for frontotemporal dementia (2013)

Frontotemporal lobar degeneration (FTLD) is the second leading cause of dementia in individuals under age 65. In many patients, the predominant pathology includes neuronal cytoplasmic or intranuclear inclusions of ubiquitinated TAR DNA binding protein 43 (FTLD-TDP). Recently, a genome-wide association study identified the first FTLD-TDP genetic risk factor, in which variants in and around the TMEM106B gene (top SNP rs1990622) were significantly associated with FTLD-TDP risk. Intriguingly, the most significant association was in FTLD-TDP patients carrying progranulin (GRN) mutations. Here, we investigated to what extent the coding variant, rs3173615 (p.T185S) in linkage disequilibrium with rs1990622, affects progranulin protein (PGRN) biology and transmembrane protein 106 B (TMEM106B) regulation. First, we confirmed the association of TMEM106B variants with FTLD-TDP in a new cohort of GRN mutation carriers. We next generated and characterized a TMEM106B-specific antibody for investigation of this protein. Enzyme-linked immunoassay analysis of progranulin protein levels showed similar effects upon T185 and S185 TMEM106B over-expression. However, over-expression of T185 consistently led to higher TMEM106B protein levels than S185. Cycloheximide treatment experiments revealed that S185 degrades faster than T185 TMEM106B, potentially due to differences in N-glycosylation at residue N183. Together, our results provide a potential mechanism by which TMEM106B variants lead to differences in FTLD-TDP risk. We studied the p.T185S TMEM106B genetic variant previously implicated in frontotemporal dementia with TAR DNA binding protein 43 pathology caused by progranulin mutations. Our cell culture studies provide evidence that the protective S185 isoform is degraded more rapidly than T185 TMEM106B, potentially due to differences in glycosylation. These findings suggest that low TMEM106B levels might protect against FTLD-TDP in these patients.
Access control of data in integrated voice/data CDMA systems: benefits and tradeoffs (1997)

In previous work, access control for data has been proposed as a method to ensure adequate quality of service (QoS) in an integrated voice/data CDMA system. The motivation behind access control is to schedule data packet transmissions in slots when voice activity is low and to curtail data transmissions when the voice load is heavy. In this work, the class of probabilistic access control schemes, wherein data transmissions are controlled by dynamically changing the permission probability, are considered. The trigger for changing the permission probability is a measure of the current uplink load. Perfect power control is assumed first, and the trigger for access control is the power control feasibility condition, Schemes based on prediction are analyzed. While prediction schemes are complex to implement, they do provide an upper bound for performance of access control schemes. A simple and practical access control scheme, proposed earlier in the literature, is then extended. It controls the permission probability for data based on uplink load and a 1-bit broadcast feedback to all of the mobiles. The performance of this scheme depends on the choice of three parameters. It is demonstrated that, through a combined choice of these parameters, access control can be tuned to perform as desired and to yield significant capacity gains over not using access control. Results are then extended to the case of imperfect power control, where the outage criterion is based on limiting the total received power at the base station. In this case, too, the simple control scheme is shown to work well.
Graphically based LP modelling for linear scheduling analysis: the POLO system (2000)

The traditional network scheduling methods such as the Critical Path Method (CPM), Programme Evaluation Review Technique (PERT), and bar charting are typically not effective for the planning of linear construction projects. Linear scheduling methods, on the other hand, model the progress of repetitive activities in sloping lines and are more effective for linear modelling and analysis. Nonetheless, their use in the construction industry has so far been very limited. Among other reasons for this is the unfamiliarity of construction personnel with these techniques, which plays a major role in hampering their application. This paper introduces a graphically based approach to assist in the linear programming (LP) modelling of linear scheduling analysis. The Planning & Optimization for Linear Operations (POLO) system provides a graphic LP modelling environment in which model formulation can be easily accomplished in a graphic and interactive fashion. Thus, the application of linear scheduling methods can be facilitated. The Isle of Palms Connector Bridge project in Mount Pleasant, South Carolina is used to demonstrate the use of the system.
Mathematical modelling of oxygen concentration in bovine and murine cumulus–oocyte complexes (2006)

Immature oocytes benefit from nutrient modification of the follicular environment by the surrounding cumulus mass. However, the oxygen concentration that the oocyte may be exposed to could be lower than the antral follicular concentration due to the metabolism of surrounding cumulus cells. Using metabolic data previously determined, we have developed a mathematical model of O(2) diffusion across the bovine and murine cumulus-oocyte complex. From this we have determined that across a physiological range of external pO(2), less than 0.25% and 0.5% O(2) is removed by cumulus cells within the bovine and murine cumulus-oocyte complex respectively. Our model differs from others as it: incorporates a term that allows for nonlinear variation of the oxygen consumption rate with oxygen concentration; considers two regions (oocyte and cumulus) sharing a common boundary, both of which consume oxygen at different non linear rates. Cumulus cells therefore remove little O(2), thus sparing this essential gas for the oocyte, which is dependent on ATP generation via oxidative phosphorylation.
Optical Single-Sideband Modulation at 60 GHz Using Electro-Absorption Modulators (2005)

With standard fiber and conventional optical double-sideband modulations, the fiber transmission distances of millimeter-wave signals are severely limited under several kilometers due to dispersion-induced signal fading. This limitation could be minimized by employing optical single-sideband (OSSB) modulation. This paper presents experiment of optical single-sideband modulation at 60 GHz, using two individual electro-absorption modulators in parallel. Stabilizing the achieved OSSB spectrum is also discussed.
Pulse-density modulation on rastered media: combining pulse-density modulation and error diffusion (1990)

An approach to generating a pulse-density modulation (PDM) on rastered media is presented. The procedure combines techniques of generating a PDM on spatial nonquantized media with the standard error-diffusion algorithm. The algorithm produces homogeneous pulse distributions along with a good reproduction of fine detail of the object.
Early assessment of response to induction therapy in acute myeloid leukemia using 18F-FLT PET/CT (2017)

<sup>18</sup>F-FLT PET/CT after induction therapy showed good sensitivity and negative-predictive value for evaluating RD in patients with AML. This preliminary study suggests that <sup>18</sup>F-FLT PET/CT may be valuable as a noninvasive tool for early assessment of the response to treatment and may provide prognostic value for survival in patients with AML.
Breast Reduction Utilizing the Maximally Vascularized Central Breast Pedicle (1985)

Hester, T. Roderick Jr. M.D.; Bostwick, John III M.D.; Miller, Leonard M.D.; Cunningham, Sally J. P.A.C.; McKissock, Paul K. M.D. Author Information
Electromechanical Properties of Lead Titanate Zirconate Ceramics with Lead Partially Replaced by Calcium or Strontium (1959)

By partially substituting Sr for Pb in ceramic lead titanate zirconate compositions near the morpho‐tropic boundary, dielectric constants greater than 1300 can be obtained along with planar couplings of about 0.50. Calcium also raises the dielectric constant, but the planar coupling level is considerably lower than that obtained with Sr. Other effects noted with Sr are a lowering of the Curie temperature, a shift in the morphotropic boundary toward the rhombohedral side, and a decrease in the distortion from cubic symmetry. In addition, Sr was found to be effective as a fluxing agent.
Data warehouse based analysis on CDR to retain and acquire customers by targeted marketing (2016)

Retaining an existing customer than acquiring a new one is less expensive in terms of marketing cost, bonus, and incentives offered etc. Telecommunication industry across the globe is stiff competitive environment where market is almost saturated and main focus of customer service becomes retaining existing customers and snatching others' customers to increase market share as well as profit. At the same time telecom industry facing the problem of churn or attrition more than anything especially for prepaid customers as the customers could switch the service providers easily. Telecom operators generate huge volume of call detail records every day for every call, SMS or internet access made by its customers. Telecom operators use these huge operational data for business processing to understand customer behavior. In this paper a mechanism is developed to store CDR data in a suitable Data Warehouse (DW) schema and analytically process these using OLAP tools to understand the prepaid customers usage, spending and propensity to marketing offers. Depending on the usage pattern proper segmentation of the customers has been done and they have been categorized for different types of targeted marketing offers and benefits to retain as well as acquire new customers.
A genome-wide RNAi screen identifies novel targets of neratinib resistance leading to identification of potential drug resistant genetic markers (2012)

Neratinib (HKI-272) is a small molecule tyrosine kinase inhibitor of the ErbB receptor family currently in Phase III clinical trials. Despite its efficacy, the mechanism of potential cellular resistance to neratinib and genes involved with it remains unknown. We have used a pool-based lentiviral genome-wide functional RNAi screen combined with a lethal dose of neratinib to discover chemoresistant interactions with neratinib. Our screen has identified a collection of genes whose inhibition by RNAi led to neratinib resistance including genes involved in oncogenesis (e.g. RAB33A, RAB6A and BCL2L14), transcription factors (e.g. FOXP4, TFEC, ZNF), cellular ion transport (e.g. CLIC3, TRAPPC2P1, P2RX2), protein ubiquitination (e.g. UBL5), cell cycle (e.g. CCNF), and genes known to interact with breast cancer-associated genes (e.g. CCNF, FOXP4, TFEC, several ZNF factors, GNA13, IGFBP1, PMEPA1, SOX5, RAB33A, RAB6A, FXR1, DDO, TFEC, OLFM2). The identification of novel mediators of cellular resistance to neratinib could lead to the identification of new or neoadjuvant drug targets. Their use as patient or treatment selection biomarkers could make the application of anti-ErbB therapeutics more clinically effective.
The fracture toughness of thin polymeric films (1996)

Abstract A fracture test using the single edge notch (SEN) geometry was developed for thin polymeric films. The SEN specimens were videotaped while they were stressed to fracture within an Instron tensile testing machine operating at a constant crosshead speed. Critical stress intensity factors for fracture instability and for the initiation of crack growth, along with the corresponding fracture energies, were obtained using a residual stress analysis. The method is applicable to brittle films and films of moderate ductility. Critical stress intensity factors ranging from 0.12 to 4.03 MPa√m were determined for thin films under plane stress conditions. Results of the test are presented for poly(di‐n‐hexylsilane), Kapton polyimide, polystyrene, and Trycite biaxially oriented polystyrene film. Validation of the test and interpretation of the results are also discussed.
Innate resistance of PD-1 blockade through loss of function mutations in JAK resulting in inability to express PD-L1 upon interferon exposure (2015)

Meeting abstracts PD-L1-negative tumors assessed by immunohistochemistry often still respond to PD-1 blockade. PD-L1 is inducible by interferon, therefore, absolute negative tumors are the ones unable to up-regulate PD-L1 in response to interferons. Genetic mutations in the interferon receptor
Unexpected pH-dependent conformation of His-64, the proton shuttle of carbonic anhydrase II (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTUnexpected pH-dependent conformation of His-64, the proton shuttle of carbonic anhydrase IISatish K. Nair and David W. ChristiansonCite this: J. Am. Chem. Soc. 1991, 113, 25, 9455–9458Publication Date (Print):December 1, 1991Publication History Published online1 May 2002Published inissue 1 December 1991https://pubs.acs.org/doi/10.1021/ja00025a005https://doi.org/10.1021/ja00025a005research-articleACS PublicationsRequest reuse permissionsArticle Views539Altmetric-Citations185LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Amino Acid Deletion at Codon 67 and Thr-to-Gly Change at Codon 69 of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Confer Novel Drug Resistance Profiles (2001)

The potential roles of an amino acid deletion at codon 67 (Delta67) and a Thr-to-Gly change at codon 69 (T69G) in the reverse transcriptase of human immunodeficiency virus (HIV) type 1 in drug sensitivity and relative replication fitness were studied. Our results suggest that the Delta67 and T69G changes can be categorized as mutations associated with multidrug resistance. The combination of both mutations with an L74I change (Delta67+T69G/L74I) leads to a novel 3'-azido-3'-deoxythymidine resistance motif and compensates for impaired HIV replication.
Deconvolution of light-scattering patterns by observing intensity fluctuations (1991)

Results are presented on the statistical fluctuations occurring in a forward-light-scattering experiment to determine the particle size distribution. A sample of glass beads was measured using a Malvern 2600D instrument and analyzed with a proposed deconvolution procedure that incorporates the observed intensity fluctuations. This procedure yields a qualitative improvement of the solution, provides error intervals, and offers a better means for model discrimination.
Matrix Metalloproteinases and Coronary Artery Disease: A Novel Therapeutic Target (1997)

Matrix metalloproteinases (MMP) are a family of enzymes that selectively digest individual components of the extracellular matrix. Their function has been studied in both normal physiologic processes and pathologic states. In the blood vessel, MMPs play an important role in maintaining the vessel's integrity by breaking down extracellular matrix while new matrix is being synthesized. This is necessary to avoid weakening from continuous mechanical stresses. However, in certain environments, these MMPs may contribute to cardiovascular pathologic processes. The purpose of this review is to first discuss the role of MMPs in coronary vascular disease. Evidence suggests that MMPs contribute to the development of de novo atherosclerotic plaques and postangioplasty restenotic plaques by allowing smooth muscle cells to migrate from the vascular media to the intima. Evidence also suggests that MMPs contribute to the rupture of these plaques by degrading the fibrous cap that surrounds them. With this increased molecular information that concerns the pathogenesis of coronary vascular disease, new molecular therapies aimed at altering these processes are being investigated. The rationale, mode of delivery, and prospects for success of these therapies will also be discussed here.
Tuning Optical Properties and Enhancing Solid-State Emission of Poly(thiophene)s by Molecular Control:  A Postfunctionalization Approach (2002)

Postfunctionalization of poly(3-hexylthiophene) (P3HT) enables the systematic study of electronic and steric effects of various functional groups on the optical and photophysical properties of 3,4-disubstituted poly(thiophene)s. In solution, these 3,4-disubstituted poly(thiophene)s exhibit a lower fluorescence yield (Φfl) than P3HT. In the solid state, bromo, chloro, and formyl groups increase Φfl, whereas nitro groups completely quench fluorescence. Phenyl, p-tolyl, 2- and 4-methoxyphenyl, 2-thienyl, biphenyl, and 1-naphthyl substituents increase the solid-state fluorescence of P3HT by a factor of 2−3 as a result of steric interactions that force the aromatic substituents perpendicular to the main chain. An extensive enhancement in the solid-state Φfl, 12 times greater than that of P3HT, is observed for polymers containing ortho-alkylphenyl or 2-(3-alkyl)thienyl groups, because of additional steric interactions between methyl or α-methylene hydrogens on the phenyl or thienyl substituents and main-chain thienyl groups. These interactions further increase the planarity of the polymer backbone and lead to an enlargement of the interplanar distance. Partial substitution of P3HT with o-tolyl groups affords polymer films with a solid-state Φfl of up to 22%.