gebhart/patrepeval huggingface dataset:
Genetic Analysis and QTL Mapping of Cell Wall Digestibility and Lignification in Silage Maize (2001)

Improving digestibility is a major goal for forage maize ( Zea mays L.) breeding programs. Quantitative trait loci (QTL) affecting forage maize digestibility‐related and agronomic traits were mapped and characterized in a set of recombinant inbred lines (RIL). Eleven traits were analyzed on whole plant samples: neutral detergent fiber (NDF), starch content (STC), crude protein content (CPC), acid detergent lignin (ADL), in vitro dry matter digestibility (IVDMD), in vitro cell wall digestibility (IVNDFD), in vitro digestibility of non‐starch and non‐soluble carbohydrate (IVDNSC), dry matter content (DMC), dry matter yield (DMY), mid‐silk date (SILK), and plant height (PHT). Evaluation was performed among the RIL populations studied per se (RILps) and in combination with a tester (TC). The genetic variances (σ 2 g ) were highly significant and, in most cases, greater than genotype × year interaction variances (σ 2 g×y ). Heritabilities ranged from 0.49 to 0.70 in RILps and from 0.12 to 0.58 in TC. Twenty‐eight QTL were identified among TC by CIM, which explained individually between 3.3 and 20.2% of the phenotypic variation ( R 2 p ) for traits related to digestibility or agronomic performance. Twenty QTL were identified among RILps, which explained individually between 6.5 and 15.3% of the phenotypic variation ( R 2 p ). Seven of these QTL were common to TC and RILps. Cell wall digestibility estimates (IVNDFD or IVDNSC) were the traits with the highest number of QTL. In contrast, we detected only one QTL for dry matter digestibility (IVDMD). Thus, it may be useful to separate IVDMD into its two component parts, cell wall digestibility, which could be estimated from line per se values, and starch content. Characteristics such as IVDNSC or IVNDFD, coupled with QTL information, would be powerful tools in the search for genes involved in maize lignification or cell wall biogenesis.
HLA-B27 antigenicity: antibodies against the chemically synthesized 63-84 peptide from HLA-B27.1 display alloantigenic specificity and discriminate among HLA-B27 subtypes. (1986)

A chemically synthesized peptide with an amino acid sequence identical to that of the segment spanning residue 63-84 of the major HLA-B27.1 subtype antigen has been obtained. Specific antibodies were raised in rabbits against this peptide, coupled to keyhole limpet hemocyanin carrier. These antibodies lysed lymphoblastoid cell lines expressing HLA-B27.1 in a complement-mediated cytotoxicity assay. They lysed neither B27-negative target cells, nor B27-positive cells expressing other B27 subtype antigens. Complement-mediated lysis of B27.1-positive targets was inhibited by free peptide and by peptide coupled to an unrelated carrier. In addition, the lytic action of the rabbit antiserum was blocked by a monoclonal antibody with no complement-activating capacity that under the conditions of the assay, was specific for HLA-B27. These results indicate that rabbit antibodies against the 63-84 peptide recognize the native HLA-B27.1 antigen; this antiserum is allospecific in character; and it discriminates among B27 subtypes. Thus the data provide direct evidence on the contribution of the hypervariable region spanning residues 63-84 to the alloantigenic specificity of HLA-B27.
Dynamic analysis and vibration control of an active tensegrity structure (2009)

Keywords: Vibration control ; Tensegrity ; Modal analysis ; Multi-objective optimization Reference EPFL-CONF-148738 Record created on 2010-05-11, modified on 2016-08-08
Review of Three-Phase PWM AC–AC Converter Topologies (2011)

This paper presents first an overview of the well-known voltage and current dc-link converter topologies used to implement a three-phase PWM ac-ac converter system. Starting from the voltage source inverter and the current source rectifier, the basics of space vector modulation are summarized. Based on that, the topology of the indirect matrix converter (IMC) and its modulation are gradually developed from a voltage dc-link back-to-back converter by omitting the dc-link capacitor. In the next step, the topology of the conventional (direct) matrix converter (CMC) is introduced, and the relationship between the IMC and the CMCs is discussed in a figurative manner by investigating the switching states. Subsequently, three-phase ac-ac buck-type chopper circuits are considered as a special case of matrix converters (MCs), and a summary of extended MC topologies is provided, including three-level and hybrid MCs. Therewith, a common knowledge basis of the individual converter topologies is established.
Nrf2-mediated Induction of Cytoprotective Enzymes by 15-Deoxy-Δ12,14-Prostaglandin J2 Is Attenuated by Alkenal/one Oxidoreductase (2006)

NADPH-dependent alkenal/one oxidoreductase (Aor) was discovered to be highly inducible in rat liver following treatment with the cancer chemopreventive agent 3H-1, 2-dithiole-3-thione. Aor was further characterized as an Nrf2-regulated antioxidative enzyme that reduces carbon-carbon double bonds in a variety of alpha, beta-unsaturated aldehydes and ketones. 15-Deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) is a reactive membrane lipid metabolite that activates multiple pathways, including Nrf2-mediated induction of cytoprotective enzymes. Physiologically, it is postulated that 15d-PGJ2 alkylates key regulatory proteins via the electrophilic carbon centers found in two alpha, beta-unsaturated ketone moieties. This current study addresses the metabolism of 15d-PGJ2 by rat Aor (rAor) and subsequent deactivation of the Nrf2 signaling pathway by both rat and human AOR. We demonstrate that induction of NADPH-dependent quinone oxidoreductase activity by 15d-PGJ2 is markedly attenuated in mouse embryonic fibroblasts that overexpress rAor. Luciferase reporter assay and quantitative real-time PCR confirmed these findings. Concentrations required for doubling the NADPH-dependent quinone oxidoreductase response are increased from 1.8 microm in wild-type to >10 microm in rat Aor transgenic fibroblasts. 15d-PGJ2 is metabolized by recombinant rAor with a Km of 9.6 microm and k(cat) of 18.5 min(-1). The major product is 12,13-dihydro-15-deoxy-Delta12,14-prostaglandin J2 (dihydro-15d-PGJ2). The reduction of C=C by Aor yielding dihydro-15d-PGJ2 abolishes the inducibility in an antioxidant response element-driven luciferase assay. Collectively, these results demonstrate that 15d-PGJ2 can be catabolized by Aor, thereby attenuating subsequent Nrf2 signaling and possibly inflammatory and apoptotic processes also influenced by 15d-PGJ2.
Some Organosilicon Compounds Containing Long-Chained n-Alkyl Groups (1959)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSome Organosilicon Compounds Containing Long-Chained n-Alkyl GroupsHENRY GILMAN, DAVID H. MILES, LEONARD O. MOORE, and CLARE W. GEROWCite this: J. Org. Chem. 1959, 24, 2, 219–224Publication Date (Print):February 1, 1959Publication History Published online1 May 2002Published inissue 1 February 1959https://pubs.acs.org/doi/10.1021/jo01084a018https://doi.org/10.1021/jo01084a018research-articleACS PublicationsRequest reuse permissionsArticle Views124Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Analysis of the cannabinoid content of strains available in the New Jersey Medicinal Marijuana Program (2019)

Though some high CBD strains are available in the New Jersey medical marijuana program, the vast majority of strains that have been tested are the THC-dominant strains which contain less than 1% CBDA. The data available from the State does not include any information on how well the different strains sell, but it can be inferred from the trend in strain types tested that the demand in the New Jersey medical market is for THC-dominant strains.
Cardiac output measured by electrical impedance tomography: Applications and limitations (2014)

Cardiac output is one of the most determining parameters to assess cardiac function and manage hemodynamically unstable patients. Its continuous and non-invasive estimation, however, remains a technical challenge. In that context, electrical impedance tomography (EIT), an emerging modality for a new class of safe and portable hemodynamic monitors, appears as an appealing candidate for the continuous monitoring of cardiac output. However, the interpretation of EIT signals requires a feasibility study to be carried out. In the context of the Nano-Tera ObeSense project, we thus proposed a model and numerical simulations to evaluate the impact of myocardial motion in the estimation of cardiac output by EIT. It was found that 64% of the cardiac EIT signal originates from the mechanical interaction of the heart muscle with its surrounding tissues. However, because these movements are correlated with ventricular blood volume, the EIT-based estimation of cardiac output is not compromised. In parallel, regarding the technical aspect of EIT, we proposed innovative solutions for its measurement setup where the wiring complexity is drastically reduced, thus opening the way towards portable EIT systems.
Care Seeking for Musculoskeletal and Respiratory Episodes in a Medicare Population (1991)

Responses to episodes of musculoskeletal illness, musculoskeletal injury, and respiratory illness are examined separately. Data are from a 1-year longitudinal study of the illness experiences of 885 Medicare recipients. Unlike studies examining aggregate use of medical services, this study examines both episodes for which medical care was sought and episodes for which no medical care was sought. Both factors associated with the decision to seek medical care for each type of episode and the illness response patterns associated with whether medical care is sought are analyzed. The three types of episode have different characteristics and profiles of illness response. Perceived seriousness and duration of the episode are the best predictors of physician visits for all episode types. However, the relative effect of predisposing and need variables on the decision to seek medical care is greatest for musculoskeletal illness episodes. These data also bear on the relationship between self-care, informal care, and the use of formal medical care. Use of nonprescription medications is shown to substitute for medical care in a significant number of illness episodes. Lay consultation and restricted activity are often linked with physician visits; however, they cannot be assumed to precede care seeking. The analytic strategy of examining responses to specific types of episodes suggests that both characteristics of the person and characteristics of the illness affect how people respond to illnesses and that the relative importance of each type of characteristic is specific to each illness type. Implications of these findings for health education are discussed.
Photoelectron spin-polarisation spectroscopy in the 5<i>s</i>5<i>p</i><sup>2</sup>-autoionisation region of indium (1990)

Photoelectron spin-polarisation measurements of In(5s25p) 2P1/2 were performed in the autoionisation region of the 5s5p2-configuration using monochromatic circularly polarised synchrotron radiation at the electron storage ring BESSY. The autoionising levels are analysed in terms of partial cross section, dipole matrix elements and phase-shift differences. In addition the measured photoelectron spin-polarisation data were used for an independent check for the assignments of the autoionising levels.
Preimplantation Genetic Diagnosis (2012)

Preimplantation genetic diagnosis (PGD) has been the prevalent method of cleavage-stage embryo biopsy for the past 2 decades. Fluorescent in situ hybridization and polymerase chain reaction have been used for diagnosis after biopsy. The primary indications for PGD have been single gene disorders, inherited chromosome abnormalities, and sexing for X-linked disease. Unlike PGD where most couples are fertile and are at risk for a specific inherited disorder, preimplantation genetic screening (PGS) is performed in infertile or subfertile couples receiving assisted reproductive techniques to achieve pregnancy. PGS uses PGD technology to help select embryos for transfer free of chromosomal abnormalities. The technique has been used in patients with advanced maternal age, repeated implantation failure, repeated miscarriages, and severe male factor infertility. Ten randomized controlled trials have shown that PGS performed in cleavage-stage embryos does not improve delivery rates for a variety of indications. Cells biopsied from cleavage-stage embryos may show high levels of chromosomal mosaicism and, therefore, may not be representative of the rest of the embryo. Although the majority of clinics still use cleavage-stage biopsy for PGD, the popularity of polar body biopsy and blastocyst biopsy has been increasing for specific indications; polar biopsy is being used in countries with laws forbidding biopsy of embryos. An added advantage with blastocyst biopsy has been the introduction of vitrification as a successful method of cryopreserving embryos. Blastocyst culture and transfer are being use routinely in many in vitro fertilization units, with reported higher survival rates, even after biopsy. As with cleavage-stage biopsy, mosaicism is problematic with blastocyst biopsy. In recent years, polymerase chain reaction has become one of the most important methods in genetic testing, allowing for diagnosis of small number of cells for PGD by amplifying and enriching a DNA sample. Further advances in PGD and PGS technology include the introduction of array comparative genomic hybridization and single nucleotide polymorphism arrays (SNP arrays). Both techniques can analyze 24 chromosomes in the embryo. The use of SNP arrays for PGD analysis will be controversial because of ethical concerns over the immense amount of genetic information obtained from each embryo. Randomized controlled trials need to be conducted using both array comparative genomic hybridization and SNP arrays for PGS to determine if either will improve delivery rates.
An UHF RFID Energy-Harvesting System Enhanced by a DC-DC Charge Pump in Silicon-on-Insulator Technology (2013)

An RF-DC converter enhanced by a DC-DC voltage booster in silicon-on-insulator technology for UHF radio frequency identification (RFID) energy harvesting is presented in this letter. When the received RF power level is -14 dBm or higher, the system, fabricated on an FR4 substrate using off-the-shelf low-cost discrete components and connected to a flexible dipole antenna, is able to produce 2.4 V DC voltage to power general-purpose electronic devices. As a simple proof of concept, a device comprising microcontroller, temperature sensor, and EEPROM is considered in this work. The experimental results demonstrate the capability of the system to autonomously perform temperature data logging up to a distance of 5 m from a conventional UHF RFID reader used as an RF energy source.
Regulatory role of metallothionein in NF‐κB activation (1999)

Metallothionein (MT), a low molecular weight, cysteine-rich metal binding protein, has been associated with cytoprotection from heavy metals and cellular oxidants. As MT has the ability to scavenge hydroxyl radicals, MT may control intracellular redox status. In the present study, we examined whether MT regulates the activity of nuclear factor-kappaB (NF-kappaB), which is one of the redox-regulated transcription factors, using the MT null embryonic cell lines established from MT null mice. We first found that tumor necrosis factor (TNF)-induced activation of the binding of NF-kappaB protein to DNA in wild type MT+/+ cells was lower than that in MT-/- cells. The NF-kappaB activation in MT-expressing cells established from MT-/- cells by the transfection of mouse MT-1 gene was also significantly lower than that in MT-/- cells. In addition, transfection of the MT gene inhibited TNF-induced IkappaB degradation and suppressed NF-kappaB-dependent gene expression induced by TNF. These results demonstrate that MT may function as a negative regulator of NF-kappaB activity.
Incretin‐based therapies for the treatment of non‐alcoholic fatty liver disease: A systematic review and meta‐analysis (2015)

The significant decrease in a key biochemical marker of hepatic inflammation following treatment with incretin-based therapies, as well as improvements in imaging and histology, suggests these agents may be effective options for managing NAFLD with comorbid T2DM.
A novel micromachined loudspeaker topology (2011)

A novel topology for a micromachined acoustic speaker suitable for cellular phones is proposed in this paper. The membrane is composed of two materials, each of them with different function: a silicon moving part acting as a rigid piston, and polymer annulus acting only as suspension. The high ratio between Young moduli and masses of membrane and suspension leads to a simpler design of the mass-spring-damper system. This new topology can be obtained thanks to a new micromachining technology, that leads to an higher adhesion between polymer and silicon. Simulations presenting the main micro-loudspeaker parameters (e.g. SPL, frequency response) are presented in details as also the principal technological steps.
NMR in Catalysis: Theoretical and Experimental Approaches (1999)

Theoretical and Experimental NMR techniques provide powerful tools for the investigation of heterogeneous catalysis. Recent advances in in situ NMR techniques are summarized, as are advances in theoretical methods. The utility of our combined theoretical/experimental approach is illustrated by studies of the pentamethylbenzenium cation and the 1,3-dimethylcyclopentenyl cation in zeolite HZSM-5, acetylene adsorption on MgO, and the isopropyl cation on frozen SbF5. We also discuss the role of the basicity of adsorbates in the formation of stable carbenium ions on zeolites.
The Sandia Laser Plasma Extreme Ultraviolet And Soft X-Ray (XUV) Light Source (1986)

Laser produced plasmas have been shown to be extremely bright sources of extreme ultra-violet and soft x-ray (XUV) radiation; however, certain practical difficulties have hindered the development of this source as a routinely usable laboratory device. To explore solutions to these difficulties, Sandia has constructed an XUV laser plasma source (LASPS) with the intention of developing an instrument that can be used for experiments requiring intense XUV radiation from 50-300 eV. The driving laser for this source is a KrF excimer with a wavelength of 248 nm, divergence of 200 jtrad, pulse width of 23 ns at 20 Hz and typical pulH energy of 500 mJ which allows for good energy coupling to the plasma at mgderate (10<sup>12</sup> W/cm<sup>2</sup>) power densities. This source has been pulsed approximately 2 x 10<sup>5</sup> times, demonstrating good tolerance to plasma debris. The source radiates from the visible to well above 1000 eV, however, to date attention has been concentrated on the 50-300 eV region. In this paper, spectral data and plasma images for both stainless steel and gold targets are presented with the gold target yielding a 200 μ, plasma and reradiating 3.9% of the pump energy into 15-73 eV band, a flux of 1.22 x 10 photons/pulse/eV into 2n sr. Further efforts will expand these measurements to rare earth targets and to higher spectralenergies. A special high throughput wide angle XUV (50-300 eV) monochromator and associated optics is being concurrently developed to collect the plasma radiation, perform energy dispersion and focus the radiation onto the experimental area.
Investigation of Treatment Failure in Neonatal Echovirus 7 Infection (2006)

Rentz, Alison C. MD*; Libbey, Jane E. MS†; Fujinami, Robert S. PhD†; Whitby, Frank G. PhD‡; Byington, Carrie L. MD* Author Information
Surface Chemistry Influences Implant Biocompatibility (2008)

Implantable medical devices are increasingly important in the practice of modern medicine. Unfortunately, almost all medical devices suffer to a different extent from adverse reactions, including inflammation, fibrosis, thrombosis and infection. To improve the safety and function of many types of medical implants, a major need exists for development of materials that evoked desired tissue responses. Because implant-associated protein adsorption and conformational changes thereafter have been shown to promote immune reactions, rigorous research efforts have been emphasized on the engineering of surface property (physical and chemical characteristics) to reduce protein adsorption and cell interactions and subsequently improve implant biocompatibility. This brief review is aimed to summarize the past efforts and our recent knowledge about the influence of surface functionality on protein:cell:biomaterial interactions. It is our belief that detailed understandings of bioactivity of surface functionality provide an easy, economic, and specific approach for the future rational design of implantable medical devices with desired tissue reactivity and, hopefully, wound healing capability.
MAP kinases and cell migration (2004)

Recent studies have demonstrated that mitogen-activated protein kinases (MAPKs), including Jun N-terminus kinase (JNK), p38 and Erk, play crucial roles in cell migration. JNK, for example, regulates cell migration by phosphorylating paxillin, DCX, Jun and microtubule-associated proteins. Studies of p38 show that this MAPK modulates migration by phosphorylating MAPK-activated protein kinase 2/3 (MAPKAP 2/3), which appears to be important for directionality of migration. Erk governs cell movement by phosphorylating myosin light chain kinase (MLCK), calpain or FAK. Thus, the different kinases in the MAPK family all seem able to regulate cell migration but by distinct mechanisms.
A Class IV Chitinase Is Highly Expressed in Grape Berries during Ripening (1997)

Abstract Chitinase activity increased markedly at the onset of ripening in grape (Vitis vinifera L.) berries and continued to increase throughout the sugar accumulation phase of berry development. In contrast, β-1,3-glucanase activity was not detected in grape berries at any stage of development. Two closely related chitinase cDNAs (VvChi4A and VvChi4B) were cloned from grapes. Sequence and Southern analysis indicate that these two clones may represent alleles of the same gene. The predicted proteins are acidic and have a signal peptide followed by a cysteine-rich, chitin-binding domain and a catalytic region. An analysis of their sequences indicates that they are class IV chitinases. The deduced protein sequence of VvChi4A has a high level of identity with the 32- and 28-kD chitinases present as haze proteins in wine. Expression of VvChi4 was high in berries and low in flowers but was not detected in leaves, roots, or seeds. No expression was detected in berries 2 to 8 weeks postflowering, but expression was high 12 to 16 weeks postflowering, which coincided with sugar accumulation and an increase in chitinase activity. Constitutive expression of VvChi4 appears to be fruit-specific and induced at high levels in grapes during ripening.