gebhart/patrepeval huggingface dataset:
Simplified minimal gated unit variations for recurrent neural networks (2017)

Recurrent neural networks with various types of hidden units have been used to solve a diverse range of problems involving sequence data. Two of the most recent proposals, gated recurrent units (GRU) and minimal gated units (MGU), have shown comparable promising results on example public datasets. In this paper, we introduce three model variants of the minimal gated unit which further simplify that design by reducing the number of parameters in the forget-gate dynamic equation. These three model variants, referred to simply as MGU1, MGU2, and MGU3, were tested on sequences generated from the MNIST dataset and the real sequences from the Reuters Newswire Topics (RNT) dataset. Here, we report on the RNT results. The new models have shown similar accuracy to the MGU model while using fewer parameters and thus lower training expense. One model variant, namely MGU2, performed better than MGU on the datasets considered, and thus may be used as an alternate to MGU or GRU in recurrent neural networks.
Effects of Temperature on Development, Longevity and Reproduction of the Soybean Aphid, Aphis glycines (Homoptera: Aphididae) (1996)

The soybean aphid, AphisgijcinesMATsuMuRA, is distributedin tropical and subtropical regions such as SoutheastAsia and partsof Africaas wcll as temperate zones such as nomhern China andJapzn CWANG et al., 1962; KoBAyAsHI et al., 1972; SINGH and van EMDEN, 1979; HILL, 1987; HIRANo and Ftull,1993), A. glycinesisan important pestof the soybean plant CWANGct al., 1962; KoGAN und TuRN]?sEEn, 1987), causing not only dircctdamagc by feeding but also indircctdamage from itsheavy secretion of honcydew on the plants,which scrvcs as a growing medium forsoety mold fungus.A. glyct'nes isalso an important vector ot' viraldiseasesCIwAKI,1979;TAKAHAsHI et aL, 1980). Although A.glycineshaslongbcenknown as a soybean pest,fewstudics have beencarried out on the mechanism involvedinitspopulation flu¢ tuations. It isncccssary to clarify thc demographicparameters and ecological characteristics ofA. gipcines as a first step toward undcrstanding the populationdynamics of thisspecies. The presentrcport fbcuseson the dcvclopmental thresholds and ratcs, intrinsicrates of incrcasc,and other pertinentdemographic parametcrs forA.glycines
Some Effects of Road, Truck and Headlamp Characteristics on Visibility and Glare in Night Driving (1974)

<div class="htmlview paragraph">Differences in characteristics between automobiles and trucks, such as driver eye height and headlamp mounting height, were examined, as well as roadway vertical and horizontal curvature and meeting beam patterns and lamp aim. Effects of these variables were evaluated by a computer simulation of nighttime meetings on a 2-lane road. The visibility distance and direct and indirect (mirror) glare discomfort effects were measured.</div> <div class="htmlview paragraph">Results suggest that: low beam headlamps on trucks should not be mounted at more than about 36 in (0.91 m) from ground level, the increase in visibility provided by the mid beam is less for truck drivers than those of automobiles, the mid beam is less affected by vertical aim variations than the low beam, the mid beam should be extinguished by the vehicle in the inside lane on curves when meeting other vehicles and when following another vehicle at less than about 200 ft (61 m).</div>
History of Breast Reconstruction (2004)

The treatment of breast cancer has evolved significantly from the original surgical technique described by Halsted. The reconstruction of the breast has also been a large interest among surgeons and patients. The history of breast reconstruction dates back to the 1800s with an attempt to transplant a lipoma to a mastectomy site. Several techniques ranging from the "walking flap" of Gilles to the free perforator flap using autogenous tissue for recreation of a breast "mound" have been established and refined. The use of tissue expanders for breast reconstruction has also been perfected over the last three decades. Breast reconstruction, which was once admonished in the early part of the 20th century, has now become a routine choice for women undergoing breast cancer surgery.
Parametric estimation of two-dimensional affine transformations [object recognition applications] (2004)

We consider the general problem of object recognition, based on a set of known templates. While the set of templates is known, the tremendous set of possible transformations and deformations between the template and the observed signature, makes any detection and recognition problem ill-defined unless this variability is taken into account. We propose a method that reduces the high dimensional problem of evaluating the orbit created by applying the set of all possible transformations in the group to a template, into a problem of analyzing a function in a low dimensional Euclidian space. In this setting, the problem of estimating the parametric model of the affine deformation is expressed using a set on non-linear operators, by a set of linear equations. This system of linear equations is then solved for the transformation parameters.
Circulating tumor DNAs and non-coding RNAs as potential biomarkers for hepatocellular carcinoma diagnosis, prognosis and response to therapy (2019)

Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide and despite improvement in therapeutic approaches, prognosis remains poor. This can be partly attributed to the fact that the majority of HCCs are diagnosed at intermediate or advanced stages. Availability of circulating biomarkers able to detect HCC at early stages could improve patients' prognosis. At present, however, alpha fetoprotein or desg-carboxyprothrombin are unable to reliably detect HCC at early stages and better circulating biomarkers are needed. Circulating tumor DNA (ctDNA) and non-coding RNAs (ncRNAs) are emerging as promising biomarkers to achieve the goal. Genetic and epigenetic alterations in ctDNA allow to pinpoint tumor-specific biomarkers, reveal tumor heterogeneity, help monitor tumor evolution over time and assess therapy efficacy. It remains to be fully evaluated the possibility of detecting these biomarkers at early tumor stages. Circulating ncRNAs are quantitative biomarkers with potential use in diagnostic, prognostic and predictive clinical settings. They may help to reveal HCC at early stages. However, because of heterogeneous and sometimes conflicting reported results, they still require validation and standardization of pre-analytical and analytical approaches before clinical applications could be envisaged.
Inexpensive construction of a 3D face model from stereo images (2007)

Construction of a three dimensional face model from stereo images is a challenging task. Most of the currently available systems for reconstruction of 3D models require special hardware for calibration. In this paper, we illustrate a mechanism to construct a three dimensional face model from two stereo images. The developed mechanism does not require any special devices to calibrate the stereo images. We used a hand-held inexpensive digital camera to take the stereo images of a face. We did not use any camera-stand to fix and measure the camera system geometry. The stereo images were taken holding the camera in hand and moving it to two slightly different viewpoints. We constructed a depth map from these two stereo images and utilized this depth map to reconstruct the three dimensional face model. The 3D face model reconstruction process described in this paper uses some existing theories and combines them to develop a new system to generate the depth map. The system requires minimal user interaction for the reconstruction.
Functional nonequality of the cardiac and skeletal ryanodine receptors (1997)

Dihydropyridine receptors (DHPRs), which are voltage-gated Ca2+ channels, and ryanodine receptors (RyRs), which are intracellular Ca2+ release channels, are expressed in diverse cell types, including skeletal and cardiac muscle. In skeletal muscle, there appears to be reciprocal signaling between the skeletal isoforms of both the DHPR and the RyR (RyR-1), such that Ca2+ release activity of RyR-1 is controlled by the DHPR and Ca2+ channel activity of the DHPR is controlled by RyR-1. Dyspedic skeletal muscle cells, which do not express RyR-1, lack excitation-contraction coupling and have an approximately 30-fold reduction in L-type Ca2+ current density. Here we have examined the ability of the predominant cardiac and brain RyR isoform, RyR-2, to substitute for RyR-1 in interacting with the skeletal DHPR. When RyR-2 is expressed in dyspedic muscle cells, it gives rise to spontaneous intracellular Ca2+ oscillations and supports Ca2+ entry-induced Ca2+ release. However, unlike RyR-1, the expressed RyR-2 does not increase the Ca2+ channel activity of the DHPR, nor is the gating of RyR-2 controlled by the skeletal DHPR. Thus, the ability to participate in skeletal-type reciprocal signaling appears to be a unique feature of RyR-1.
Phosphorylation of Transitory Starch Is Increased during Degradation  (2004)

The starch excess phenotype of Arabidopsis mutants defective in the starch phosphorylating enzyme glucan, water dikinase (EC 2.7.9.4) indicates that phosphorylation of starch is required for its degradation. However, the underlying mechanism has not yet been elucidated. In this study, two in vivo systems have been established that allow the analysis of phosphorylation of transitory starch during both biosynthesis in the light and degradation in darkness. First, a photoautotrophic culture of the unicellular green alga Chlamydomonas reinhardtii was used to monitor the incorporation of exogenously supplied (32)P orthophosphate into starch. Illuminated cells incorporated (32)P into starch with a constant rate during 2 h. By contrast, starch phosphorylation in darkened cells exceeded that in illuminated cells within the first 30 min, but subsequently phosphate incorporation declined. Pulse-chase experiments performed with (32)P/(31)P orthophosphate revealed a high turnover of the starch-bound phosphate esters in darkened cells but no detectable turnover in illuminated cells. Secondly, leaf starch granules were isolated from potato (Solanum tuberosum) plants grown under controlled conditions and glucan chains from the outer granule layer were released by isoamylase. Phosphorylated chains were purified and analyzed using high performance anion-exchange chromatography and matrix-assisted laser desorption/ionization mass spectrometry. Glucans released from the surface of starch granules that had been isolated from darkened leaves possessed a considerably higher degree of phosphorylation than those prepared from leaves harvested during the light period. Thus, in the unicellular alga as well as in potato leaves, net starch degradation is accompanied with an increased phosphorylation of starch.
Model Studies of DNA C5‘ Radicals. Selective Generation and Reactivity of 2‘-Deoxyadenosin-5‘-yl Radical (2003)

The reaction of hydrated electrons (e(aq)(-)) with 8-bromo-2'-deoxyadenosine has been investigated by radiolytic methods coupled with product studies and addressed computationally by means of DFT-B3LYP calculations. Pulse radiolysis revealed that this reaction was complete in approximately 0.3 mus, and, at this time, no significant absorption was detected. The spectrum of a transient developed in 20 mus has an absorbance in the range 300-500 nm (epsilon(max) congruent with 9600 M(-1) cm(-1) at 360 nm), and it was assigned to aromatic aminyl radical 3. Computed vertical transitions (TD-UB3LYP/6-311+G) are in good agreement with the experimental observations. Radical 3 is obtained by the following reaction sequence: one-electron reductive cleavage of the C-Br bond that gives the C8 radical, a fast radical translocation from the C8 to C5' position, and an intramolecular attack of the C5' radical at the C8,N7 double bond of the adenine moiety. The rate constant for the cyclization is 1.6 x 10(5) s(-1). On the basis of the theoretical findings, the cyclization step is highly stereospecific. The rate constants for the reactions of C5' and aminyl 3 radicals with different oxidants were determined by pulse radiolysis methods. The respective rate constants for the reaction of 2'-deoxyadenosin-5'-yl radical with dioxygen, Fe(CN)(6)(3)(-), and MV(2+) in water at ambient temperature are 1.9 x 10(9), 4.2 x 10(9), and 2.2 x 10(8) M(-1) s(-1). The value for the reaction of aminyl radical 3 with Fe(CN)(6)(3-) is 8.3 x 10(8) M(-1) s(-1), whereas the reaction with dioxygen is reversible. Tailored experiments allowed the reaction mechanism to be defined in some detail. A synthetically useful radical cascade process has also been developed that allows in a one-pot procedure the conversion of 8-bromo-2'-deoxyadenosine to 5',8-cyclo-2'-deoxyadenosine in a diastereoisomeric ratio (5'R):(5'S) = 6:1 and in high yield, by reaction with hydrated electrons in the presence of K(4)Fe(CN)(6).
PRECISE: Software for Prediction of cis-Acting Regulatory Elements (2005)

The regulation of gene expression at the transcription initiation level is highly complex and requires the presence of multiple transcription factors. These transcription factors are often proteins or peptides that bind to the so-called cis-acting elements, which are present in the promoter regions and conserved among different species. In order to predict these cis-acting elements, a computer program called PRECISE (Prediction of REgulatory CIS-acting Elements) was developed. The power of the tool lies in its user-friendly interface and in the possibility of using empirical motif frequency tables to filter through the many discovered motifs. The tools to create the empirical motif frequency table (e.g., from a whole genome sequence) are included in the package. In the first case study, the upstream regions of all the genes in the Arabidopsis genome were used to create an empirical motif frequency table and a set of 64 upstream sequences of genes known to be involved in starch metabolism was subjected to analysis by PRECISE. The 20 motifs with the highest specificity in the selected set were analyzed in more detail. Of these 20 motifs, 15 showed a very high or complete homology to the sequences of known cis-acting elements. These cis-acting elements are regulated by light, auxin, and abscisic acid, and confer specific expression in sink organs such as leaves and seeds. All these factors have been shown to play an important role in starch biosynthesis. In the second case study, the upstream regions of 16 genes whose transcription is induced by gibberellins (GA) in Arabidopsis were analyzed with PRECISE and compared to the motifs present in the PLACE database. Among the most promising motifs found by PRECISE were 6 of the 17 known GA motifs. These results indicate the power of the PRECISE software package in the prediction of regulatory elements.
Calibration for time domain reflectometry modular in digital communication analyzer (2017)

As the clock frequency and data rate of digital circuit become much higher, signal integrity has become increasingly important. Impedance mismatch of signal transmission paths can cause signal reflection, decrease the signal quality, so the impedance in the signal transmission paths needs to be understood and controlled. During impedance measurements, the preferred method is time domain reflectometry (TDR), which uses high performance digital communication analyzer equipped with TDR modules. A lot of digital communication analyzers equipped with TDR modules in those enterprises need to be calibrated, sent to Shanghai Institute of measurement and testing technology every year. But so far, relevant verification regulation or calibration specification of TDR module has not issued domestic. In order to meet the calibration requirements of our customers, combined with our many years of experience in pulse parameters calibration, carefully studying the technical specifications of TDR module produced by Tektronix, Inc. and Agilent technologies, making full use of the standard instruments in our pulse parameter laboratory, we calibrate the TDR module of digital communication analyzer and meet requirements of customers.
Superoxide Dismutase Improves Posttraumatic Cortical Blood Flow in Rats (1995)

Oxygen free radicals, such as the superoxide anion, are known to mediate damage to the cerebral microcirculation following traumatic brain injury. The purpose of this study was to determine if superoxide dismutase (SOD), a scavenger of superoxide anion, could alter posttraumatic cortical blood flow. Following barbiturate anesthesia, rats were surgically prepared for moderate fluid percussion brain injury. Cortical blood flow contralateral to the site of injury was measured using laser-Doppler flowmetry. Laser-Doppler flowmetry assesses flow by measuring cell volume and velocity, which are multiplied electronically to give flow. Starting 10 min before injury, animals received either superoxide dismutase (24,000 U/kg bolus, followed by continuous infusion of 1600 U/kg/min) or an equal volume of saline. Blood pressure, heart rate, and cortical blood flow were measured up to 1 h posttrauma. Rats receiving superoxide dismutase had significantly higher cortical blood flow posttrauma (F = 6.91, p < 0.02). One hour posttrauma, the blood flow in SOD-treated rats was 89 +/- 8% of preinjury baseline, whereas this value was only 66 +/- 6% of control in saline-treated rats. SOD caused not only greater blood velocity but also less reduction in cortical blood volume after injury. There were no significant differences between the groups with respect to blood pressure or heart rate. This study further supports the role of oxygen radical-mediated cerebrovascular dysfunction following traumatic brain injury and is the first to show the beneficial effect of SOD on cortical blood flow following fluid percussion brain injury.
“Hit-and-Run” Transformation by Adenovirus Oncogenes (2001)

According to classical concepts of viral oncogenesis, the persistence of virus-specific oncogenes is required to maintain the transformed cellular phenotype. In contrast, the "hit-and-run" hypothesis claims that viruses can mediate cellular transformation through an initial "hit," while maintenance of the transformed state is compatible with the loss ("run") of viral molecules. It is well established that the adenovirus E1A and E1B gene products can cooperatively transform primary human and rodent cells to a tumorigenic phenotype and that these cells permanently express the viral oncogenes. Additionally, recent studies have shown that the adenovirus E4 region encodes two novel oncoproteins, the products of E4orf6 and E4orf3, which cooperate with the viral E1A proteins to transform primary rat cells in an E1B-like fashion. Unexpectedly, however, cells transformed by E1A and either E4orf6 or E4orf3 fail to express the viral E4 gene products, and only a subset contain E1A proteins. In fact, the majority of these cells lack E4- and E1A-specific DNA sequences, indicating that transformation occurred through a hit-and-run mechanism. We provide evidence that the unusual transforming activities of the adenoviral oncoproteins may be due to their mutagenic potential. Our results strongly support the possibility that even tumors that lack any detectable virus-specific molecules can be of viral origin, which could have a significant impact on the use of adenoviral vectors for gene therapy.
Transgene Expression of Green Fluorescent Protein and Germ Line Transmission in Cloned Pigs Derived from <i>In Vitro</i> Transfected Adult Fibroblasts (2008)

The pig represents the xenogeneic donor of choice for future organ transplantation in humans for anatomical and physiological reasons. However, to bypass several immunological barriers, strong and stable human genes expression must occur in the pig's organs. In this study we created transgenic pigs using in vitro transfection of cultured cells combined with somatic cell nuclear transfer (SCNT) to evaluate the ubiquitous transgene expression driven by pCAGGS vector in presence of different selectors. pCAGGS confirmed to be a very effective vector for ubiquitous transgene expression, irrespective of the selector that was used. Green fluorescent protein (GFP) expression observed in transfected fibroblasts was also maintained after nuclear transfer, through pre- and postimplantation development, at birth and during adulthood. Germ line transmission without silencing of the transgene was demonstrated. The ubiquitous expression of GFP was clearly confirmed in several tissues including endothelial cells, thus making it a suitable vector for the expression of multiple genes relevant to xenotransplantation where tissue specificity is not required. Finally cotransfection of green and red fluorescence protein transgenes was performed in fibroblasts and after nuclear transfer blastocysts expressing both fluorescent proteins were obtained.
Introduction (2012)

Subject Early Christianity Religion and Art, Literature, and Music Christian Spirituality and Religious Experience
Review Radiolabelled monoclonal antibodies in oncology II. Clinical applications in diagnosis (1991)

The clinical applications of this approach to the management of patients with ovarian cancer and of patients with colorectal cancer are emphasized. The introduction of stable 99Tcm labelling of monoclonal antibodies means that radioimmunoscintigraphy is able to become routinely available in nuclear medicine departments.
Decreased colostral immunoglobulin absorption in calves with postnatal respiratory acidosis (1990)

The effect of postnatal acid-base status on the absorption of colostral immunoglobulins by calves was examined in 2 field studies. In study 1, blood pH at 2 and 4 hours after birth was related to serum IgG1 concentration 12 hours after colostrum feeding (P less than 0.05). Decreased IgG1 absorption from colostrum was associated with respiratory, rather than metabolic, acidosis, because blood PCO2 at 2 and 4 hours after birth was negatively related to IgG1 absorption (P less than 0.05), whereas serum bicarbonate concentration was not significantly related to IgG1 absorption. Acidosis was frequently observed in the 30 calves of study 1. At birth, all calves had venous PCO2 value greater than or equal to 60 mm of Hg, 20 of the calves had blood pH less than 7.20, and 8 of the calves had blood bicarbonate concentration less than 24 mEq/L. Blood pH values were considerably improved by 4 hours after birth; only 7 calves had blood pH values less than 7.20. Calves lacking risk factors for acidosis were examined in study 2, and blood pH values at 4 hours after birth ranged from 7.25 to 7.39. Blood pH was unrelated to IgG1 absorption in the calves of study 2. However, blood PCO2 was again found to be negatively related to colostral IgG1 absorption (P less than 0.005). Results indicate that postnatal respiratory acidosis in calves can adversely affect colostral immunoglobulin absorption, despite adequate colostrum intake early in the absorptive period.
Εισαγωγή: Αναπτυξιακή Ψυχολογία: έρευνα, εφαρμογές και προεκτάσεις (2021)

Introduction of the Special Issue