gebhart/patrepeval huggingface dataset:
Skeletal muscle lipid metabolism with obesity (2003)

The objectives of this study were to 1). examine skeletal muscle fatty acid oxidation in individuals with varying degrees of adiposity and 2). determine the relationship between skeletal muscle fatty acid oxidation and the accumulation of long-chain fatty acyl-CoAs. Muscle was obtained from normal-weight [n = 8; body mass index (BMI) 23.8 +/- 0.58 kg/m(2)], overweight/obese (n = 8; BMI 30.2 +/- 0.81 kg/m(2)), and extremely obese (n = 8; BMI 53.8 +/- 3.5 kg/m(2)) females undergoing abdominal surgery. Skeletal muscle fatty acid oxidation was assessed in intact muscle strips. Long-chain fatty acyl-CoA concentrations were measured in a separate portion of the same muscle tissue in which fatty acid oxidation was determined. Palmitate oxidation was 58 and 83% lower in skeletal muscle from extremely obese (44.9 +/- 5.2 nmol x g(-1) x h(-1)) patients compared with normal-weight (71.0 +/- 5.0 nmol x g(-1) x h(-1)) and overweight/obese (82.2 +/- 8.7 nmol x g(-1) x h(-1)) patients, respectively. Palmitate oxidation was negatively (R = -0.44, P = 0.003) associated with BMI. Long-chain fatty acyl-CoA content was higher in both the overweight/obese and extremely obese patients compared with normal-weight patients, despite significantly lower fatty acid oxidation only in the extremely obese. No associations were observed between long-chain fatty acyl-CoA content and palmitate oxidation. These data suggest that there is a defect in skeletal muscle fatty acid oxidation with extreme obesity but not overweight/obesity and that the accumulation of intramyocellular long-chain fatty acyl-CoAs is not solely a result of reduced fatty acid oxidation.
Low‐dose <scp>TNF</scp> augments fracture healing in normal and osteoporotic bone by up‐regulating the innate immune response (2015)

The mechanism by which trauma initiates healing remains unclear. Precise understanding of these events may define interventions for accelerating healing that could be translated to the clinical arena. We previously reported that addition of low-dose recombinant human TNF (rhTNF) at the fracture site augmented fracture repair in a murine tibial fracture model. Here, we show that local rhTNF treatment is only effective when administered within 24 h of injury, when neutrophils are the major inflammatory cell infiltrate. Systemic administration of anti-TNF impaired fracture healing. Addition of rhTNF enhanced neutrophil recruitment and promoted recruitment of monocytes through CCL2 production. Conversely, depletion of neutrophils or inhibition of the chemokine receptor CCR2 resulted in significantly impaired fracture healing. Fragility, or osteoporotic, fractures represent a major medical problem as they are associated with permanent disability and premature death. Using a murine model of fragility fractures, we found that local rhTNF treatment improved fracture healing during the early phase of repair. If translated clinically, this promotion of fracture healing would reduce the morbidity and mortality associated with delayed patient mobilization.
Intracellular temperature mapping with fluorescence-assisted photoacoustic-thermometry (2013)

Measuring intracellular temperature is critical to understanding many cellular functions but still remains challenging. Here, we present a technique-fluorescence-assisted photoacoustic thermometry (FAPT)-for intracellular temperature mapping applications. To demonstrate FAPT, we monitored the intracellular temperature distribution of HeLa cells with sub-degree (0.7 °C) temperature resolution and sub-micron (0.23 <i>μ</i>m) spatial resolution at a sampling rate of 1 kHz. Compared to traditional fluorescence-based methods, FAPT features the unique capability of transforming a regular fluorescence probe into a concentration- and excitation-independent temperature sensor, bringing a large collection of commercially available generic fluorescent probes into the realm of intracellular temperature sensing.
Current Progress of Virus-mimicking Nanocarriers for Drug Delivery (2017)

Nanomedicines often involve the use of nanocarriers as a delivery system for drugs or genes for maximizing the therapeutic effect and/or minimizing the adverse effect. From drug administration to therapeutic activity, nanocarriers must evade the host's immune system, specifically and efficiently target and enter the cell, and release their payload into the cell cytoplasm by endosomal escape. These processes constitute the early infection stage of viruses. Viruses are a powerful natural nanomaterial for the efficient delivery of genetic information by sophisticated mechanisms. Over the past two decades, many virus-inspired nanocarriers have been generated to permit successful drug and gene delivery. In this review, we summarize the early infection machineries of viruses, of which the part has so far been utilized for delivery systems. Furthermore, we describe basics and applications of the bio-nanocapsule, which is a hepatitis B virus-mimicking nanoparticle harboring nearly all activities involved in the early infection machineries (i.e., stealth activity, targeting activity, cell entry activity, endosomal escaping activity).
Effects of beam energy purity on junction depths in submicron devices (2002)

As CMOS device dimensions continue to scale down, source-drain junction depths are reduced accordingly. Shallow p+ junction formation will require the use of very low energy (1-3 keV) source/drain implants at doses /spl ges/1/spl times/10/sup 15//cm/sup 2/ for forming final p+ source/drain junctions <0.1 /spl mu/m. Deceleration of boron ions after mass analysis has been proposed as a method to provide adequate beam currents in this energy range without extensive redesign of the source chamber and beamline. Charge exchange reactions that occur after the mass analysis magnet but prior to the deceleration electrode can result in contamination of the final beam with a fractional component of ions possessing the original extraction energy. This has the potential to seriously impact the off-state leakage current of advanced PMOS devices. The pressure dependent nature of charge exchange reactions suggests that device performance will show significant variations in a typical manufacturing environment.
Hardware-Based Load Value Trace Filtering for On-the-Fly Debugging (2013)

Capturing program and data traces during program execution unobtrusively on-the-fly is crucial in debugging and testing of cyber-physical systems. However, tracing a complete program unobtrusively is often cost-prohibitive, requiring large on-chip trace buffers and wide trace ports. This article describes a new hardware-based load data value filtering technique called Cache First-access Tracking. Coupled with an effective variable encoding scheme, this technique achieves a significant reduction of load data value traces, from 5.86 to 56.39 times depending on the data cache size, thus enabling cost-effective, unobtrusive on-the-fly tracing and debugging.
IRIS: a Chat-oriented Dialogue System based on the Vector Space Model (2012)

This system demonstration paper presents IRIS (Informal Response Interactive System), a chat-oriented dialogue system based on the vector space model framework. The system belongs to the class of examplebased dialogue systems and builds its chat capabilities on a dual search strategy over a large collection of dialogue samples. Additional strategies allowing for system adaptation and learning implemented over the same vector model space framework are also described and discussed. 1
Properties of Various Pure Irons (1964)

Recent iron and steel alloys are very complicated.It is necessary to research the fundamental properties of iron for the development of these alloys.For this purpose the properties of various kinds of commercial and trial manufactured pure irons were investigated at first.Pure iron contains generally C, Si, Mn, P, S, Ni, Mo, V, Ag and Sn as impurities.Mechanical properties of full annealed pure iron are approximately as follows.Hardness: HRB 30, tensile strength: 30kg/mm2, elongation: 50%, reduction of area: 70%.Ultrahigh purity iron (Fe>99·99%) is high in work hardening rate and has good corrosion resistance.
Parallélisme de comportements et pratiques concertées (1993)

Phlips Louis. Parallélisme de comportements et pratiques concertées. In: Revue d'économie industrielle, vol. 63, 1er trimestre 1993. Politique de la concurrence. pp. 25-44.
Cobalt(II) tetrasulfophthalocyanine on titanium dioxide: A new efficient electron relay for the photocatalytic formation and depletion of hydrogen peroxide in aqueous suspensions (1987)

A novel synthesis for the covalent linkage of cobalt(II) tetrasulfophthalocyanine (Co^(II)TSP) to the surface of titanium dioxide (TiO_2) particles (d ≤ 0.5 µm) is described. Upon irradiation with light that exceeds the bandgap energy (E_g) of TiO_2 (i.e., ⋋ 5 380 nm), Co^(II)TSP is reduced to Co^ITSP under anoxic conditions both as a dry powder and in aqueous suspension. The photochemical reduction is shown to be fully reversible in the presence of molecular oxygen (O_2). Hydrogen peroxide (H_2O_2) is produced upon irradiation of an aerated aqueous suspension of the 'hybrid" catalyst, TiO__2-Co^(II)TSP. Formation kinetics are followed in situ with a polarographic detector (detection limit ≃ 10^(7-) M H_2O_2); quantum yields, ϕ_(H_2O_2) between 0.16 and 0.49 have been determined. The reactive photocatalytic center appears to be generated by the attachment of molecular oxygen in the open apical coordination site of the hybrid Co^(II)TSP complex. Formation of Co^(II)TSP-O_2^(•-) is enhanced by the binding of TiO^- surface groups in the opposite apical position. Hydrogen peroxide is produced in a two-step electron transfer from the conduction band via the Co(III) center. The involvement of free radical intermediates in this mechanism appears to be highly unlikely. On the basis of its observed chemical and photochemical stability and the high quantum yields for O_2 reduction, the newly developed hybrid material is proposed to be applicable as a potent and stable oxidation catalyst.
Target-Based Identification and Optimization of 5-Indazol-5-yl Pyridones as Toll-like Receptor 7 and 8 Antagonists Using a Biochemical TLR8 Antagonist Competition Assay (2020)

Inappropriate activation of endosomal TLR7 and TLR8 occurs in several autoimmune diseases, in particular systemic lupus erythematosus (SLE). Herein, the development of a TLR8 antagonist competition assay and its application for hit generation of dual TLR7/8 antagonists are reported. The structure-guided optimization of the pyridone hit <b>3</b> using this biochemical assay in combination with cellular and TLR8 cocrystal structural data resulted in the identification of a highly potent and selective TLR7/8 antagonist (<b>27</b>) with <i>in vivo</i> efficacy. The two key steps for optimization were (i) a core morph guided by a TLR7 sequence alignment to achieve a dual TLR7/8 antagonism profile and (ii) introduction of a fluorine in the piperidine ring to reduce its basicity, resulting in attractive oral pharmacokinetic (PK) properties and improved TLR8 binding affinity.
Mining closed discriminative dyadic sequential patterns (2011)

A lot of data are in sequential formats. In this study, we are interested in sequential data that goes in pairs. There are many interesting datasets in this format coming from various domains including parallel textual corpora, duplicate bug reports, and other pairs of related sequences of events. Our goal is to mine a set of closed discriminative dyadic sequential patterns from a database of sequence pairs each belonging to one of the two classes +ve and -ve. These dyadic sequential patterns characterize the discriminating facets contrasting the two classes. They are potentially good features to be used for the classification of dyadic sequential data. They can be used to characterize and flag correct and incorrect translations from parallel textual corpora, automate the manual and time consuming duplicate bug report detection process, etc. We provide a solution of this new problem by proposing new search space traversal strategy, projected database structure, pruning properties, and novel mining algorithms. To demonstrate the scalability and utility of our solution, we have experimented with both synthetic and real datasets. Experiment results show that our solution is scalable. Mined patterns are also able to improve the accuracy of one possible downstream application, namely the detection of duplicate bug reports using pattern-based classification.
Design of an electrically actuated lower extremity exoskeleton (2006)

Human exoskeletons add the strength and endurance of robotics to a human's innate intellect and adaptability to help people transport heavy loads over rough, unpredictable terrain. The Berkeley lower extremity exoskeleton (BLEEX) is the first human exoskeleton that was successfully demonstrated to walk energetically autonomous while supporting its own weight plus an external payload. This paper details the design of the electric motor actuation for BLEEX and compares it to the previously designed hydraulic actuation scheme. Clinical gait analysis data was used to approximate the torques, angles and powers required at the exoskeleton's leg joints. Appropriately sized motors and gearing are selected, and put through a thorough power analysis. The compact electric joint design is described and the final electric joint performance is compared with BLEEX's previous hydraulic actuation. Overall, the electric actuation scheme is about twice as efficient and twice as heavy as the hydraulic actuation.
Designing Algorithms to Assess Collision Risk in Coastal Waters (2019)

Current-use CPA (Closest Point of Approach) algorithm has three limitations. Firstly, it does not take into account ship's course-keeping ability. As small ships are more affected by its speed and sea wave, fluctuation of heading is bigger and frequent, and this phenomenon result in fluctuation of Distance of CPA (DCPA) and Time of CPA(TCPA) value. Secondly, ship's maneuverability upon ship size is not considered in the algorithm. As ship is larger, there are more restrictions on direction and speed control, thus avoiding action is larger and slower. Thirdly, since depth are considered, the algorithm cannot identify risk of stranding result from navigation on shallow water. In order to solve these problems, this study aims to design algorithms using ship information including length and draft of ships and water depth as well as course, speed, and position used in the current CPA algorithm. Ship length from Automatic Identification System (AIS) can represent the ship's size, so it is used to subdivide the CPA algorithm according to ship size. Draft information from AIS and depth information from Electronic Nautical Chart (ENC) are used to calculate the ship's stranding risk. First of all, course correction algorithm takes moving average of the cumulative course value for the reliability of the course of small craft. This information helps to identify the risk of collision with small vessels with fast speed and frequent movement change. Secondly, the range of TCPA and DCPA values are graded and risk levels are assigned accordingly. As small vessel has a greater ability to avoid collision risk, TCPA and DCPA values of small vessels are higher than large vessels in same risk level. The stranding risk is determined by whether Under Keel Clearance (UKC) is secured between the ship's draft and the depth of the water in the direction the ship is proceeding. The algorithm processes a vast information of surrounding marine traffic and environment information within a short time and provide navigators with intuitive collision risk level. Thus it is expected that the algorithm shortens the duration for decision making of navigators for collision avoidance in coastal waters navigation. Korea Institute of Ocean Science & Technology (KIOST) has developed Smart Escape Guidance Agent (SEGA) and its subsystem SEGA Ship, and the collision risk algorithm in this study will be utilized to provide an escape navigation route when ships face with an emergency.
A new automatic blood pressure kit auscultates for accurate reading with a smartphone (2016)

The widely used oscillometric automated blood pressure (BP) monitor was continuously questioned on its accuracy. A novel BP kit named Accutension which adopted Korotkoff auscultation method was then devised. Accutension worked with a miniature microphone, a pressure sensor, and a smartphone. The BP values were automatically displayed on the smartphone screen through the installed App. Data recorded in the phone could be played back and reconfirmed after measurement. They could also be uploaded and saved to the iCloud. The accuracy and consistency of this novel electronic auscultatory sphygmomanometer was preliminarily verified here. Thirty-two subjects were included and 82 qualified readings were obtained. The mean differences ± SD for systolic and diastolic BP readings between Accutension and mercury sphygmomanometer were 0.87 ± 2.86 and -0.94 ± 2.93 mm Hg. Agreements between Accutension and mercury sphygmomanometer were highly significant for systolic (ICC = 0.993, 95% confidence interval (CI): 0.989-0.995) and diastolic (ICC = 0.987, 95% CI: 0.979-0.991). In conclusion, Accutension worked accurately based on our pilot study data. The difference was acceptable. ICC and Bland-Altman plot charts showed good agreements with manual measurements. Systolic readings of Accutension were slightly higher than those of manual measurement, while diastolic readings were slightly lower. One possible reason was that Accutension captured the first and the last korotkoff sound more sensitively than human ear during manual measurement and avoided sound missing, so that it might be more accurate than traditional mercury sphygmomanometer. By documenting and analyzing of variant tendency of BP values, Accutension helps management of hypertension and therefore contributes to the mobile heath service.
<title>Fourier descriptor features for acoustic landmine detection</title> (2002)

Signatures of buried landmines are often difficult to separate from those of clutter objects. Often, shape information is not directly obtainable from the sensors used for landmine detection. The Acoustic Sensing Technology (AST), which uses a Laser Doppler Vibrometer (LDV) that measures the spatial pattern of particle velocity amplitude of the ground surface in a variety of frequency bands, offers a unique look at subsurface phenomena. It directly records shape related information. Generally, after preprocessing the frequency band images in a downward looking LDV system, landmines have fairly regular shapes (roughly circular) over a range of frequencies while clutter tends to exhibit irregular shapes different from those of landmines. Therefore, shape description has the potential to be used in discriminating mines from clutter. Normalized Fourier Descriptors (NFD) are shape parameters independent of size, angular orientation, position, and contour starting conditions. In this paper, the stack of 2D frequency images from the LDV system are preprocessed by a linear combination of order statistics (LOS) filter, thresholding, and 2D and 3D connected labeling. Contours are extracted form the connected components and aggregated to produce evenly spaced boundary points. Two types of Normalized Fourier Descriptors are computed from the outlines. Using images obtained from a standard data collection site, these features are analyzed for their ability to discriminate landmines from background and clutter such as wood and stones. From a standard feature selection procedure, it was found that a very small number of features are required to effectively separate landmines from background and clutter using simple pattern recognition algorithms. Details of the experiments are included.
First demonstration of 0.9 μm pixel global shutter operation by novel charge control in organic photoconductive film (2015)

Organic photoconductive film (OPF) image sensor is the strong candidate to extend image sensor application and create new image sensor world. This paper introduces new charge generation and extraction operation in OPF sensor. By spatial and temporal control of electric field in OPF, high speed global shutter operation in sub-micron pixel, electrical iris control without ND filter, phase difference detective autofocusing are demonstrated.
Chimeric regulatory light chains as probes of smooth muscle myosin function. (1993)

Functional domains of the smooth muscle regulatory light chain (LC) were identified from the assembly and motor properties of smooth muscle myosin containing chimeric LCs, in which the N- and C-terminal halves of the smooth and skeletal LCs were interchanged. A C-terminal domain was also expressed. The affinity of these LCs for the smooth muscle myosin heavy chain (HC) is: wild-type LC > N-skeletal/C-smooth > N-smooth/C-skeletal approximately skeletal LC >> C-terminal domain. The C-terminal half of the LC thus contains an isoform-specific HC binding site, but the two halves of the LC must interact for tight binding. Smooth muscle myosin containing chimeric or skeletal LCs can no longer assume the folded monomeric conformation, suggesting that control of assembly involves both halves of the LC. Dephosphorylation/phosphorylation of the N-skeletal/C-smooth chimera nonetheless regulates the ability of smooth muscle myosin to move actin. Myosin containing phosphorylated N-smooth/C-skeletal or skeletal LCs, in contrast, is locked in the "off" state. Interactions between the stronger binding C-terminal domain of the LC and the HC are therefore primarily responsible for the regulatory capabilities of this subunit. Localization of the regulatory LC at the head/rod junction by electron microscopy establishes that phosphorylation-induced changes must be transmitted over 10 nm within the head for product release to be enhanced.
Downstream antibody purification using aqueous two‐phase extraction (2010)

The extraction of antibodies using a polyethylene glycol (PEG)-citrate aqueous two-phase system (ATPS) was investigated. Studies using purified monoclonal antibody (mAb) identified operating ranges for successful phase formation and factors that significantly affected antibody partitioning. The separation of antibody and host cell protein (HCP) from clarified cell culture media was examined using statistical design of experiments (DOE). The partitioning of antibody was nearly complete over the entire range of the operating space examined. A model of the HCP partitioning was generated in which both NaCl and citrate concentrations were identified as significant factors. To achieve the highest purity, the partitioning of HCP from cell culture fluid into the product containing phase was minimized using a Steepest Descent algorithm. An optimal ATPS consisting of 14.0% (w/w) PEG, 8.4% (w/w) citrate, and 7.2% (w/w) NaCl at pH 7.2 resulted in a product yield of 89%, an approximate 7.6-fold reduction in HCP levels relative to the clarified cell culture fluid before extraction and an overall purity of 70%. A system consisting of 15% (w/w) PEG, 8% (w/w) citrate, and 15% (w/w) NaCl at pH 5.5 reduced product-related impurities (aggregates and low molecular product fragments) from ∼40% to less than 0.5% while achieving 95% product recovery. At the experimental conditions that were optimized in the batch mode, a scale-up model for the use of counter-current extraction technology was developed to identify potential improvements in purity and recovery that could be realized in the continuous operational mode.
Observation of a Photon Echo (1964)

Received 2 September 1964DOI:https://doi.org/10.1103/PhysRevLett.13.567©1964 American Physical Society
Isolierung und Strukturaufklärung von Chlamydocin (1974)

Abstract The constitution of Chlamydocin – a metabolite of Diheterospora chlamydosporia with pronounced cytostatic activity – is proposed on the basis of chemical reactions and physical data. The synthesis of a derivative of a new amino acid is described. The biological activities of this compound and of derivatives of Chlamydocin are discussed.