gebhart/patrepeval huggingface dataset:
<i>In vitro</i> Differentiation of Human Parthenogenetic Stem Cells into Neural Lineages (2011)

Human parthenogenetic stem cells are derived from the inner cell mass of blastocysts obtained from unfertilized oocytes that have been stimulated to develop without any participation of male gamete. As parthenogenesis does not involve the destruction of a viable human embryo, the derivation and use of human parthenogenetic stem cells does not raise the same ethical concerns as conventional embryonic stem cells. Human parthenogenetic stem cells are similar to embryonic stem cells in their proliferation and multilineage in vitro differentiation capacity. The aim of this study is to derive multipotent neural stem cells from human parthenogenetic stem cells that are stable to passaging and cryopreservation, and have the ability to further differentiate into functional neurons. Immunocytochemistry, quantitative real-time PCR, or FACS were used to confirm that the derived neural stem cells express neural markers such as NES, SOX2 and MS1. The derived neural stem cells keep uniform morphology for at least 30 passages and can be spontaneously differentiated into cells with neuron morphology that express TUBB3 and MAP2, and fire action potentials. These results suggest that parthenogenetic stem cells are a very promising and potentially unlimited source for the derivation of multipotent neural stem cells that can be used for therapeutic applications.
Correction to Structure–Activity Relationship Study of <i>N</i><sup>6</sup>-(2-(4-(1<i>H</i>-Indol-5-yl)piperazin-1-yl)ethyl)-<i>N</i><sup>6</sup>-propyl-4,5,6,7-tetrahydrobenzo[<i>d</i>]thiazole-2,6-diamine Analogues: Development of Highly Selective D3 Dopamine Receptor Agonists along with a Highly Potent D2/D3 Agonist and Their Pharmacological Characterization (2013)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to Structure–Activity Relationship Study of N6-(2-(4-(1H-Indol-5-yl)piperazin-1-yl)ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine Analogues: Development of Highly Selective D3 Dopamine Receptor Agonists along with a Highly Potent D2/D3 Agonist and Their Pharmacological CharacterizationMark Johnson, Tamara Antonio, Maarten E. A. Reith, and Aloke K. Dutta*Cite this: J. Med. Chem. 2013, 56, 2, 589–590Publication Date (Web):January 4, 2013Publication History Published online4 January 2013Published inissue 24 January 2013https://pubs.acs.org/doi/10.1021/jm301634chttps://doi.org/10.1021/jm301634ccorrectionACS PublicationsCopyright © 2013 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views781Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (197 KB) Get e-Alertsclose Get e-Alerts
Simple Mobile Services for IMS (2008)

In this paper we present an open source platform for mobile services execution and creation that has been ported to work into the IMS architecture. The platform has been developed in the context of the simple mobile services research project and it includes a mobile client called MOVE (Mobile Open and Very Easy) developed using the Java 2 Micro Edition (J2ME) platform. The paper describes the features of the service execution/creation platforms, then it shortly introduces the IMS (IP multimedia subsystem), finally it describes the process of porting the simple mobile services architectural elements into the IMS architecture.
SYNTHESIS AND ANTIVIRAL EVALUATION OF SOME NEW GLYCOSYLTHIOUREAS CONTAINING A QUINAZOLINONE NUCLEUS (2002)

A new synthesis of glycosylthioureas containing a quinazolinone nucleus is described utilizing per-O-acetylglycopyranosylisothiocyanates and several aminoquinazolinones as starting compounds. Structural proofs of these compounds are provided from elemental analyses, IR, 1H and 13C NMR spectra and mass spectra. The biological activity of these compounds has been studied.
Robust Speech Recognition Using Factorial HMMs for Home Environments (2007)

We focus on the problem of speech recognition in the presence of nonstationary sudden noise, which is very likely to happen in home environments. As a model compensation method for this problem, we investigated the use of factorial hidden Markov model (FHMM) architecture developed from a clean-speech hidden Markov model (HMM) and a sudden-noise HMM. While in conventional studies this architecture is defined only for static features of the observation vector, we extended it to dynamic features. In addition, we performed home-environment adaptation of FHMMs to the characteristics of a given house. A database recorded by a personal robot called PaPeRo in home environments was used for the evaluation of the proposed method. Isolated word recognition experiments demonstrated the effectiveness of the proposed method under noisy conditions. Home-dependent word FHMMs (HD-FHMMs) reduced the word error rate by 20.5 compared to that of the clean-speech word HMMs.
Harvesting and enrichment of hematopoietic progenitor cells mobilized into the peripheral blood of normal donors by granulocyte-macrophage colony-stimulating factor (GM-CSF) or G-CSF: potential role in allogeneic marrow transplantation (1995)

To explore the use of stem/progenitor cells from peripheral blood (PB) for allogeneic transplantation, we have studied the mobilization of progenitor cells in normal donors by growth factors. Normal subjects were administered either granulocyte-macrophage colony-stimulating factor (GM-CSF) at 10 micrograms/kg/d, or G-CSF at 10 micrograms/kg/d, or a combination of G- and GM-CSF at 5 micrograms/kg/d each, administered subcutaneously for 4 days, followed by leukapheresis on day 5. Mononuclear cells expressing CD34 (CD34+ cells) were selectively enriched by affinity labeling using Dynal paramagnetic microspheres (Baxter Isolex; Baxter Healthcare Corp, Santa Ana, CA). The baseline CD34+ cells in peripheral blood before mobilization was 0.07% +/- 0.05% (1.6 +/- 0.7/microL; n = 18). On the fifth day after stimulation (24 hours after the fourth dose), the CD34+ cells were 0.99% +/- 0.40% (61 +/- 14/microL) for the 8 subjects treated with G-CSF, 0.25% +/- 0.25% (3 +/- 3/microL, both P < .01 v G-CSF) for the 5 subjects administered GM-CSF, and for the 5 subjects treated with G- and GM-CSF, 0.65% +/- 0.28% (41 +/- 18/microL, P < .5 v GM-CSF). Parallel to this increase in CD34+ cells, clonogenic assays showed a corresponding increase in CFU-GM and BFU-E. The total number of CD34+ cells collected from the G-CSF group during a 3-hour apheresis was 119 +/- 65 x 10(6) and was not significantly different from that collected from the group treated with G- and GM-CSF (101 +/- 35 x 10(6) cells), but both were greater than that from the group treated with GM-CSF (12.6 +/- 6.1 x 10(6); P < .01 for both comparisons). Analysis of the CD34+ subsets showed that a significantly higher percentage of cells with the CD34+/CD38- phenotype is found after mobilization with G- and GM-CSF. In the G-CSF group, immunomagnetic selection of CD34+ cells permitted the enrichment of the CD34+ cells in the apheresis product to 81% +/- 11%, with a 48% +/- 12% yield and to a purity of 77% +/- 21% with a 51% +/- 15% recovery in the G- and GM-CSF group. T cells were depleted from a mean of 4.5 +/- 2.0 x 10(9) to 4.3 +/- 5.2 x 10(6) after selection, representing 99.9% depletion. We conclude that it is feasible to collect sufficient numbers of PB progenitor cells from normal donors with one to two leukapheresis procedures for allogeneic transplantation.(ABSTRACT TRUNCATED AT 250 WORDS)
Paraffin Precipitation in the Formation in Dom João Field, Brazil (1990)

ABSTRACT Despite prolonged water injection and a number of reservoir studies, only 10% of the original oil in place has been recovered during 43 years of production from shallow reservoirs in the Dom João oil field, Recôncavo Basin. The formation temperature being close to the pour point of the crude oil raises the possibility for the ocurrence of paraffin precipitation in the reservoir. A field stimulation test was performed using a nitrogen generation system/emulsion (SGN/EMULSÃO) technique. Two nitrogenated salt solutions, emulsified in a selected organic solvent, were injected into the formation through a single well; their reaction released both nitrogen and heat, in turn yielding a capacity to remove paraffin deposits. A comparison between the production rates and oil compositions before and after stimulation indicates that paraffin deposition was occurring inside the formation. A possible explanation for this phenomenon would be the cooling effect resulting from a post-migration uplifting of the the formation.
Modification Tolerability of Soybean Proglycinin (1995)

Proglycinins containing multiple modifications, that is, with two kinds of single modifications, designed previously to improve food functions, were assessed for ability to form proper conformations. This was done to discover the modification tolerability of proglycinin. Based on our results, three new criteria are proposed for judging formation of proper conformations. Our results suggest that proglycinin molecules tolerate different combinations of single modifications without misfolding.
Arylphosphinic Acids: Dissociation Constants and Reaction with Diazomethane<sup>1</sup> (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTArylphosphinic Acids: Dissociation Constants and Reaction with Diazomethane1LOUIS D. QUIN and MARTHA R. DYSARTCite this: J. Org. Chem. 1962, 27, 3, 1012–1014Publication Date (Print):March 1, 1962Publication History Published online1 May 2002Published inissue 1 March 1962https://pubs.acs.org/doi/10.1021/jo01050a078https://doi.org/10.1021/jo01050a078research-articleACS PublicationsRequest reuse permissionsArticle Views167Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Application of Soft-Torque Rotary Table in Mobile Bay (1992)

ABSTRACT Shell Offshore Inc. (SOI) has successfully installed and operated the Soft Torque Rotary System (STRS) for the first time on two drilling rigs operating in Mobile Bay. Application of the STRS has significantly reduced torque fluctuations (up to 80%), torsional drill string vibrations, and bit slip-stick conditions. The STRS attenuates and interrupts the torsional oscillations of the drill string and thus prevents the buildup of energy in torsional waves that are reflected back and forth between the bit and the rotary table. It can be installed on any rig equipped with an independent electronically driven rotary table or top drive. The STRS is inexpensive (about $25M for Shell group companies), easy to install, and has been a factor in improved drilling penetration rates realized on the SL 531 No. 3, a complex directional well drilled in the Mobile Bay area. Additionally, the STRS has been instrumental in avoiding expensive ($5MM-$10MM) drill string failures on the SL 531 No. 3. Further work needs to be done to fully quantify the impact of the STRS on reducing these types of failures.
Comparative in vitro biocompatibility of nickel-titanium, pure nickel, pure titanium, and stainless steel: genotoxicity and atomic absorption evaluation. (1999)

The genotoxicity level of nickel-titanium (NiTi) was compared to that of its pure constituents, pure nickel (Ni) and pure titanium (Ti) powders, and also to 316L stainless steel (316L SS) as clinical reference material. In order to do so, a dynamic in vitro semiphysiological extraction was performed with all metals using agitation and ISO requirements. Peripheral blood lymphocytes were then cultured in the presence of all material extracts, and their comparative genotoxicity levels were assessed using electron microscopy-in situ end-labeling (EM-ISEL) coupled to immunogold staining. Cellular chromatin exposition to pure Ni and 316L SS demonstrated a significantly stronger gold binding than exposition to NiTi, pure Ti, or the untreated control. In parallel, graphite furnace atomic absorption spectrophotometry (AAS) was also performed on all extraction media. The release of Ni atoms took the following decreasing distribution for the different resulting semiphysiological solutions: pure Ni, 316L SS, NiTi, Ti, and controls. Ti elements were detected after elution of pure titanium only. Both pure titanium and nickel-titanium specimens obtained a relative in vitro biocompatibility. Therefore, this quantitative in vitro study provides optimistic results for the eventual use of nickel-titanium alloys as surgical implant materials.
Biodegradable thermosensitive copolymer hydrogels for drug delivery (2007)

Biodegradable thermogelling copolymer hydrogels have great applicative potential in areas such as sustained drug release, gene delivery and tissue engineering. These injectable materials can be implanted in the human body with minimal surgical intervention. The thermosensitive copolymers have been incorporated with a variety of biocompatible and biodegradable components such as poly(D,L-lactic acid-co-glycolic acid), poly(L-lactic acid), poly (L-carprolactone), poly([R]-3-hydroxybutyrate), poly(organophosphazene), poly(peptide), poly(propylene fumarate), poly(propylene phosphate), polyacetal and poly(ortho ester). Various formulations consisting of the copolymers and therapeutic agents have been developed and the sustained release of these agents has been demonstrated. This review aims to provide a comprehensive summary of the recent developments in this field of study and highlights the most recent intellectual property and research papers.
Equilibriums in reactions of fluorocarbon olefins, imines, and ketones with fluoride ion (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEquilibriums in reactions of fluorocarbon olefins, imines, and ketones with fluoride ionJohn A. Young and Margaret H. BennettCite this: J. Org. Chem. 1977, 42, 25, 4055–4058Publication Date (Print):December 1, 1977Publication History Published online1 May 2002Published inissue 1 December 1977https://pubs.acs.org/doi/10.1021/jo00445a014https://doi.org/10.1021/jo00445a014research-articleACS PublicationsRequest reuse permissionsArticle Views124Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Electromechanical coupling of isotropic fibrous networks with tailored auxetic behavior induced by water-printing under tension (2021)

A wetting–stretching method is presented to enhance the auxeticity and piezoresistivity of a random network made of a carbon nanotube-paper composite.
<i>Saccharomyces cerevisiae</i>-Secreted Fusion Proteins Pfs25 and Pfs28 Elicit Potent<i>Plasmodium falciparum</i>Transmission-Blocking Antibodies in Mice (1998)

Transmission-blocking vaccines based on sexual-stage surface antigens of Plasmodium falciparum may assist in the control of this lethal form of human malaria. Two vaccine candidates, Pfs25 and Pfs28, were produced as single recombinant fusion proteins. The 39-kDa chimeric proteins, having a C-terminal His6 tag, were secreted by Saccharomyces cerevisiae, using the prepro-alpha-factor leader sequence. Pfs25-28 fusion proteins were significantly more potent than either Pfs25 or Pfs28 alone in eliciting antibodies in mice that blocked oocyst development in Anopheles freeborni mosquitoes: complete inhibition of oocyst development in the mosquito midgut was achieved with fewer vaccinations, at a lower dose, and for a longer duration than with either Pfs25 or Pfs28 alone. Increased antigen-specific immunoglobulin G titers and highly significant lymphoproliferative stimulation by Pfs28-containing antigens suggest the presence of an immunodominant helper T-cell epitope in the Pfs28 portion of the fusion proteins. This epitope may be responsible for the enhanced humoral response to both Pfs25 and Pfs28 antigens. Protein production of the fusion protein was improved 12-fold by converting Pfs28 codons to yeast-preferred codons (TBV28), using a modified ADH2 promoter and incorporating a (Glu-Ala)2 repeat after the Kex2 cleavage site.
A survey of QoS enhancements for IEEE 802.11 wireless LAN (2004)

Abstract Quality‐of‐service (QoS) is a key problem of today's IP networks. Many frameworks (IntServ, DiffServ, MPLS etc.) have been proposed to provide service differentiation in the Internet. At the same time, the Internet is becoming more and more heterogeneous due to the recent explosion of wireless networks. In wireless environments, bandwidth is scarce and channel conditions are time‐varying and sometimes highly lossy. Many previous research works show that what works well in a wired network cannot be directly applied in the wireless environment. Although IEEE 802.11 wireless LAN (WLAN) is the most widely used IEEE 802.11 wireless LAN (WLAN) standard today, it cannot provide QoS support for the increasing number of multimedia applications. Thus, a large number of 802.11 QoS enhancement schemes have been proposed, each one focusing on a particular mode. This paper summarizes all these schemes and presents a survey of current research activities. First, we analyze the QoS limitations of IEEE 802.11 wireless MAC layers. Then, different QoS enhancement techniques proposed for 802.11 WLAN are described and classified along with their advantages/drawbacks. Finally, the upcoming IEEE 802.11e QoS enhancement standard is introduced and studied in detail. Copyright © 2004 John Wiley & Sons, Ltd.
Phase II study of paclitaxel therapy for unresectable biliary tree carcinomas. (1996)

These findings indicate that paclitaxel, administered on this schedule, is tolerable, but is unlikely to have activity in metastatic carcinomas of the biliary tree. It is unclear whether a different regimen of paclitaxel, or another taxane, may have activity in these neoplasms.
Total Synthesis of (±)-Martinellic Acid (2001)

A 14-step synthesis of martinellic acid (1) that proceeds in 3% overall yield has been completed using the reaction of aniline 11 with Meldrum's acid-activated vinylcyclopropane 4 to give vinyl pyrrolidinone 12, condensation of aldehyde 13 with N-benzylglycine to form an azomethine ylide that cyclizes to give 14, selective reduction of 14 to amino alcohol 16 with LiBH(4) and MeOH, and guanidine formation by reaction of a cyanamide with 3-methyl-2-buten-1-amine in hexafluoro-2-propanol at 120 degrees C as key steps. [structure: see text]
Segmentation by transduction (2008)

This paper addresses the problem of segmenting an image into regions consistent with user-supplied seeds (e.g., a sparse set of broad brush strokes). We view this task as a statistical transductive inference, in which some pixels are already associated with given zones and the remaining ones need to be classified. Our method relies on the Laplacian graph regularizer, a powerful manifold learning tool that is based on the estimation of variants of the Laplace-Beltrami operator and is tightly related to diffusion processes. Segmentation is modeled as the task of finding matting coefficients for unclassified pixels given known matting coefficients for seed pixels. The proposed algorithm essentially relies on a high margin assumption in the space of pixel characteristics. It is simple, fast, and accurate, as demonstrated by qualitative results on natural images and a quantitative comparison with state-of-the-art methods on the Microsoft GrabCut segmentation database.
Design of an Industrially Feasible Twisted-Stack HTS Cable-in-Conduit Conductor for Fusion Application (2013)

Taking advantage of the large experience of the ENEA Superconducting Laboratory in the manufacture and characterization of large scale superconducting systems, a project was launched, aimed at using High Temperature Superconductor (HTS) 2G wires for the manufacture of a cable-in-conduit conductor (CICC). In particular, the main aim was the definition of a conductor design fully compatible with existing cabling technologies, to be promptly transferred to an industrial scale production. The considered layout is based on 150 HTS tapes, arranged as five layered structures of twisted tapes wound on a helically slotted core with external round jacket. All manufacturing steps (slotted core production, tape stacking and insertion into the ducts, external wrapping and jacketing) are fulfilled by using equipments and technologies available at TRATOS Cavi S.p.A. These CICCs are intended for operation using forced flow of Helium. A 2D local thermal model has been developed for the optimization of the cooling configuration. This conductor is designed to target 20 kA at 4.2 K and 15 T (or, alternatively, higher temperature, in self-field and LN2 cooling) corresponding to a J <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">e</sub> of about 55 A/mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . The production of a short dummy sample revealed that the exploited industrial production process is very promising for the development of HTS CICC.