gebhart/patrepeval huggingface dataset:
Prevalence and Spectrum of Germline Mutations of the p53 Gene among Patients with Sarcoma (1992)

New germline mutations of the p53 gene are rare among patients with "sporadic" sarcoma but may be common in patients with sarcoma whose background includes either multiple primary cancers or a family history of cancer. Diverse mutations of this gene were associated with an increased likelihood of cancer; hence, the entire gene should be considered a target for heritable mutation. It appears that the group of patients with cancer who carry germline mutations of the p53 gene is more diverse than is suggested by the clinical definition of the Li-Fraumeni syndrome. The identification of carriers could be of substantial clinical importance.
The potential use of AKAP18δ as a drug target in heart failure patients (2008)

We have shown that A-kinase anchoring protein (AKAP)18delta is important for organizing the molecular machinery that mediates adrenergic control of calcium reabsorption into sarcoplasmic reticulum. Calcium reabsorption is essential for relaxation and filling of the heart and is the rate-limiting step for making the heart beat faster in response to adrenaline or noradrenaline. We conclude that targeting AKAP18delta may have application in manipulating calcium reabsorption and protecting the heart from adrenergic pacing at the level of specific signaling events in heart failure patients.
Proof-Carrying Hardware: Runtime Formal Verification for Secure Dynamic Reconfiguration (2010)

This article proposes Proof-carrying Hardware (PCH) as a novel approach to bring formal verification to hardware security for reconfigurable platforms. The Proof-carrying Hardware combines a hardware module and a formal proof of safety which adheres to a previously established safety policy. These are produced by an untrusted external source and delivered in a unsecured way. The proof can then comparatively easily be verified by the reconfigurable platform, i.e., with a fraction of the effort that was required for computing the proof. The consumer can trust the module without any previous guarantees about any step of the production or the transmission.
Simulations of racetrack microtron for acceleration of picosecond electron pulse (1999)

Low emittance sub-picosecond electron pulses are expected to be used in a wide field, such as free electron laser, laser acceleration, femtosecond X-ray generation by inverse Compton scattering, and pulse radiolysis, etc. In order to produce the low emittance sub-picosecond electron pulses, we are developing a compact racetrack microtron (RTM) with a new 5 MeV injection system adopting an laser photocathode RF gun. The operation of the RTM is kept under the steady state of beam loading for long pulse mode so far. We have investigated for the first time by numerical simulation the case of short- and single-pulse acceleration. The RTM is also useful to accelerate a picosecond electron pulse under a transient state of beam loading. In the simulation, a picosecond electron pulse is accelerated to 139 MeV in the RTM for the injection of about a 5 MeV pulse with a pulse length of 3 picoseconds, a charge of 1 nC per pulse, and an emittance of 1.8 /spl pi/mm mrad, which corresponds to the output of the RF gun.
Pneumococcal vaccination in adults: recommendations, trends, and prospects. (2007)

The US Centers for Disease Control and Prevention recommends vaccination against Streptococcus pneumoniae for all people age 65 and older and also for younger people at high risk. However, experts continue to debate the efficacy of the vaccine; most observational studies found it beneficial, while clinical trials were inconclusive as a group. Although pneumococcal vaccination may or may not protect against pneumonia or death from any cause, it does significantly decrease the risk of invasive pneumococcal disease and is worthwhile for this reason.
Internet2-based 3D PET image reconstruction using a PC cluster (2002)

We describe an approach to fast iterative reconstruction from fully three-dimensional (3D) PET data using a network of PentiumIII PCs configured as a Beowulf cluster. To facilitate the use of this system, we have developed a browser-based interface using Java. The system compresses PET data on the user's machine, sends these data over a network, and instructs the PC cluster to reconstruct the image. The cluster implements a parallelized version of our preconditioned conjugate gradient method for fully 3D MAP image reconstruction. We report on the speed-up factors using the Beowulf approach and the impacts of communication latencies in the local cluster network and the network connection between the user's machine and our PC cluster.
Context-Driven Business Process Adaptation for Ad Hoc Changes (2008)

The success of a business process depends on whether it meets its business goal as well as non-functional requirements in the context of business process-oriented applications. Adaptability is an important requirement that aims to dynamically and quickly reconfigure business processes to support new and rapidly changing business contexts. However, traditional process adaptation technologies have problems to adapt to more dynamic ad hoc changes. In this paper we present a context driven business process adaptation approach in which business process context can be gathered and reasoned to modify business process structure in an efficient way to adjust business process capability to satisfy business requirements. We also demonstrate adaptation detective mechanism and strategies which provides real-time reaction to the process environment and flexible runtime adaptation to fluctuating business level demand. By comprising context driven technology and autonomic business process adaptation strategies, the methodology offers flexibility and adaptability in business process management.
Ship attitude prediction based on Input Delay Neural Network and measurements of gyroscopes (2017)

Due to the uncertainty and random nature of ocean waves, the accurate prediction of ship attitude is hard to be achieved, especially in high sea states. A ship attitude prediction method using Input Delay Neural Network (IDNN) is proposed in this paper. One of the advantages of this method is that it takes the measurements of Microelectromechanical Systems (MEMS) gyrosocpes, besides ship Euler angles, as the inputs of IDNN, which can greatly increase the prediction precision of ship attitude with little increase in system cost. The effectiveness of proposed method is validated through a data set sampled in a ship simulation hardware system. Moreover, the factors that affect the prediction performance are also explored through a set of experiments. The prediction method proposed can achieve high precision, that is, the root-mean-square prediction errors for roll, pitch and yaw, are 0.26 deg, 0.12 deg and 0.26 deg, respectively, when the prediction time is 2 sec. This precision is high enough for most attitude stabilization control systems.
Due-date based scheduling and control policies in a multiproduct semiconductor wafer fabrication facility (1998)

This paper focuses on lot release control and scheduling problems in a semiconductor wafer fab producing multiple products that have different due dates and different process flows. For lot release control, it is necessary to determine the type of a wafer lot and the time to release wafers into the wafer fab, while it is necessary to determine sequences of processing waiting lots in front of workstations for lot scheduling. New dispatching rules are developed for lot release control and scheduling considering special features of the wafer fabrication process. Simulation experiments are carried out to test the dispatching rules. Results show that lot release control and lot scheduling at photolithography workstations are more important than scheduling at other workstations. Also, it is shown that new dispatching rules work better in terms of tardiness of orders than existing rules such as the EDD (earliest due date) rule and other well-known dispatching rules for multimachine scheduling.
Switchable optical polarizer based on electrochromism in stretch-aligned polyaniline (2003)

We report on the polarizing electrochromic (EC) effect of a conjugated polymer. This has been achieved in a planar flexible electrochemical device cell comprised of a patterned stretch-aligned thin film of polyaniline and an electrolyte, all made on a polyethylene foil substrate. The resulting device exhibits polarized absorption characteristics, of a dichroic ratio of 4, that can be controlled by the voltage applied. Also, thin flexible EC polarizers have been realized by combining two stretch-aligned polyaniline films with orthogonal stretching direction. In the resulting EC polarizer the orientation of the polarized absorption can be switched between two orthogonal directions, depending on the voltage applied.
Characterization of wheat thioredoxin <i>h</i> cDNA and production of an active <i>Triticum aestivum</i> protein in <i>Escherichia coli</i> (1998)

Two cDNA clones, pTaM13.38 and pTd14.13.2, encoding a Triticum aestivum and a Triticum durum thioredoxin h, respectively, were isolated from mid-maturation seed cDNA libraries. The T aestivum thioredoxin h has a molecular mass of 13.5 kDa and that from T durum has a molecular mass of 13.8 kDa. These two wheat thioredoxin h are 98.5% similar and contain the canonical WCGPC active site and the important structural and functional amino acids that are conserved in thioredoxin sequences. The recombinant T. aestivum thioredoxin h (TrxTa) overproduced in BL21(DE3)pLysS was purified to homogeneity by a three-step procedure including heat treatment, anion-exchange chromatography and gel filtration. TrxTa showed a lower stability to high temperature than Escherichia coli thioredoxin or plant thioredoxin m. The molecular mass of TrxTa, determined by mass spectrometry, is 13,391 Da and corresponds to a protein lacking the first methionine residue, as confirmed by its N-terminal end sequence AASAAT. Using the 5,5'-dithiobis(2-nitrobenzoic acid)-reduction assay and monobromobimane revelation we showed that TrxTa is specifically reduced by wheat NADP:thioredoxin reductase (NTR), and not by E. coli NTR. TrxTa is able to reduce identified target proteins i.e. wheat seed alpha-amylase inhibitors (chloroform/methanol-soluble proteins). The presence of a putative transmembrane domain at the N-terminal end of the two wheat thioredoxins raises the question of whether these proteins are membrane anchored.
Prevalence and concordance between the clinical and the post-mortem diagnosis of dementia in a psychogeriatric clinic (2017)

Introduction: The aim of our study is to describe the types of dementia found in a series of patients and to estimate the level of agreement between the clinical diagnosis and post-mortem diagnosis. Material and methods: We conducted a descriptive analysis of the prevalence of the types of dementia found in our series and we established the level of concordance between the clinical and the post-mortem diagnoses. The diagnosis was made based on current diagnostic criteria. Results: 114 cases were included. The most common clinical diagnoses both at a clinical and autopsy level were Alzheimer disease and mixed dementia but the prevalence was quite different. While at a clinical level, prevalence was 39% for Alzheimer disease and 18% for mixed dementia, in the autopsy level, prevalence was 22% and 34%, respectively. The agreement between the clinical and the autopsy diagnoses was 62% (95% CI, 53%-72%). Conclusions: Almost a third of our patients were not correctly diagnosed in vivo. The most common mistake was the underdiagnosis of cerebrovascular pathology. Resumen: Introducción: Describir los tipos de demencia en una serie de pacientes valorados en una clínica psicogeriátrica y estimar el grado de acuerdo entre el diagnóstico clínico y el anatomopatológico. Material y métodos: Realizamos un análisis descriptivo de la prevalencia de los tipos de demencia entre los pacientes valorados en nuestro centro y establecemos el grado de concordancia entre el diagnóstico clínico y el anatomopatológico. Los diagnósticos se establecieron en función de los criterios diagnósticos vigentes en cada momento. Resultados: Ciento catorce casos cumplieron los criterios de inclusión. Los diagnósticos más frecuentes tanto a nivel clínico como anatomopatológico fueron enfermedad de Alzheimer y demencia mixta, pero la prevalencia se invirtió pasando de un 39% y 18% a nivel clínico a un 22% y 34% a nivel anatomopatológico respectivamente. La concordancia entre el diagnóstico clínico y el anatomopatológico fue de un 62% (IC 95%: 53-72%). Conclusiones: Casi un tercio de nuestros pacientes no tenía un diagnóstico certero en vida, fundamentalmente a expensas del infradiagnóstico a nivel clínico de la enfermedad cerebrovascular. Keywords: Dementia prevalence, Dementia diagnosis accuracy, Alzheimer's disease, Cerebrovascular disease, Post-mortem diagnosis, Mixed brain pathologies, Palabras clave: Prevalencia de demencia, Fiabilidad diagnóstica en demencia, Enfermedad de Alzheimer, Enfermedad cerebrovascular, Diagnóstico post-mortem, Comorbilidad cerebral
What Is the Predictive Value of Animal Models for Vaccine Efficacy in Humans? (2017)

Animal models are an essential feature of the vaccine design toolkit. Although animal models have been invaluable in delineating the mechanisms of immune function, their precision in predicting how well specific vaccines work in humans is often suboptimal. There are, of course, many obvious species differences that may limit animal models from predicting all details of how a vaccine works in humans. However, careful consideration of which animal models may have limitations should also allow more accurate interpretations of animal model data and more accurate predictions of what is to be expected in clinical trials. In this article, we examine some of the considerations that might be relevant to cross-species extrapolation of vaccine-related immune responses for the prediction of how vaccines will perform in humans.
Development of a position-sensitive detector for TOF-PET (2007)

A position-sensitive detector (PS-detector) for a time-of-flight (TOF) PET system has been developed and evaluated. The PS-detector consists of a flat panel position- sensitive photomultiplier tube (PS-PMT; Hamamatsu R8400-00- M64 MOD) and 2.9 mm times 2.9 mm times 20 mm LYSO crystals arranged in a 16 times 16 array. The PS-PMT has eight stages of metal channel dynode and 8times8 multiple anodes in a 52.0 mm square times 14.8 mm high metal can package. In order to compensate for the non-uniform amplitude from the multiple anodes of the PS-PMT, an application specific integrated circuit (ASIC) having 64-channel variable gain amplifiers is attached to the front-end circuits. The ASIC also has a readout circuit to reduce 64-channel outputs down to four position signals and an energy signal. The performance of PS-detector was evaluated for TOF-PET application. The coincidence response functions (CRFs) were measured by scanning a <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">22</sup> Na point source with 0.4 mm steps across the center of a pair of the PS-detectors. The average FWHM value of the CRFs is 2.3 mm. The energy resolution corresponding to each crystal element at 511 keV is 10.9% on the average. The timing resolutions of the PS-detector at FWHM, with a BaF <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> reference detector, range from 421 ps to 787 ps, with an average of 505 ps. A new PS-PMT having high QE is now under development. The timing resolutions of the new PS-PMT coupled to a LaBr <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> and a LYSO single crystal are 236 ps FWHM and 366 ps FWHM, respectively, with a BaF <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> reference detector. We are developing a new TOF-PET system with PS-detectors.
Solid-Phase Development of a 1-Hydroxybenzotriazole Linker for Heterocycle Synthesis Using Analytical Constructs (2001)

The development of a 1-hydroxybenzotriazole linker for the synthesis of heterocyclic derivatives is described, utilizing analytical construct methodology to facilitate the analysis of resin samples. A UV-chromophore-containing analytical construct enabled the accurate determination of resin loading and the automated monitoring of key reactions using only small quantities of resin. The syntheses of an array of isoxazole derivatives are reported.
Translation of web queries using anchor text mining (2002)

This article presents an approach to automatically extracting translations of Web query terms through mining of Web anchor texts and link structures. One of the existing difficulties in cross-language information retrieval (CLIR) and Web search is the lack of appropriate translations of new terminology and proper names. The proposed approach successfully exploits the anchor-text resources and reduces the existing difficulties of query term translation. Many query terms that cannot be obtained in general-purpose translation dictionaries are, therefore, extracted.
One-pot Synthesis of radial ZnO microparticles deposited on graphene nanosheets as the Anode Materials for Lithium-Ion Batteries (2016)

A novel ZnO/graphene nanosheet (ZnO/GN) composite has been successfully synthesized by a facile one-pot hydrothermal method. ZnO micro-particles, with the quasi-spherical radial morphology, are uniformly deposited on the wrinkled GN. According to the hydrothermal method used and characterization results observed, the formation process is proposed. When adopted as anodes for lithium-ion batteries, the ZnO/GN composite shows enhanced cyclability and rate capability compared with the pristine ZnO counterpart. The ZnO/GN electrode could yield a discharge capacity of 620 mAh g -1 at the 2 nd cycle with the corresponding coulombic efficiency of 71 % over 100 cycles at 0.2 A g -1 . In addition, the ZnO/GN composite exhibits a good rate capability with discharge capacity of 132 mAh g -1 at high current density of 3.2 A g -1 . This improved electrochemical performance stems from the positive combinative effects of both radial microparticle structure of ZnO and GN additives, wherein radial ZnO microparticle provides a large surface with a short ion transport and electrolyte diffusion length and GN renders a flexible robust conductive matrix, buffering the large volume changes during the charge/discharge processes.
Grief-Work in Contemporary American Cultural Criticism (1993)

In Studies on Hysteria , Freud articulated a theory of affect which resonates with the dominant tradition in Western culture of the emotions as negative: the emotions are associated with woman and with death and they are something to be gotten rid of. In Freud's hysterical women, affect is represented as strangulated and cut off' from the memory to which it was attached (SE 2: xviii) . Affect, unable to speak in its own language, is transcribed into another language, the bodily symptoms of hysteria which Freud later described in Five Lectures on PsychoAnalysis as precipitates of emotional experiences (SE 11: 14). The goal of analysis, however, is not so much to give affect voice a subtle vocabulary, a rich poetics as to purge it once it has been remembered. Affect in short is represented as pathogenic, often paralyzing (SE 2: 11), something that needs to be discharged or, in that strange Freudian word, abreacted through the labor of analysis or work, Freud's preferred term. Freud's basic model of the functioning of the mental apparatus not the emotional apparatus is thus homeostatic, quietistic,
Spinophilin Blocks Arrestin Actions in Vitro and in Vivo at G Protein-Coupled Receptors (2004)

Arrestin regulates almost all G protein-coupled receptor (GPCR)-mediated signaling and trafficking. We report that the multidomain protein, spinophilin, antagonizes these multiple arrestin functions. Through blocking G protein receptor kinase 2 (GRK2) association with receptor-Gbetagamma complexes, spinophilin reduces arrestin-stabilized receptor phosphorylation, receptor endocytosis, and the acceleration of mitogen-activated protein kinase (MAPK) activity following endocytosis. Spinophilin knockout mice were more sensitive than wild-type mice to sedation elicited by stimulation of alpha2 adrenergic receptors, whereas arrestin 3 knockout mice were more resistant, indicating that the signal-promoting, rather than the signal-terminating, roles of arrestin are more important for certain response pathways. The reciprocal interactions of GPCRs with spinophilin and arrestin represent a regulatory mechanism for fine-tuning complex receptor-orchestrated cell signaling and responses.
A finger-ring UWB monopole antenna for BAN and PAN (2010)

In this paper, we discuss a possibility of the small size and wearable fingerring antenna for UWB band (7.25GHz-10.25GHz). Details of the simulated results of the proposed antennas are presented and discussed. And it is confirmed that the human finger does not affect on the input impedance characteristic of the proposed double finger-ring antenna.
Thymic hormone (THF) therapy in immunosuppressed children with lymphoproliferative neoplasia and generalized varicella. (1977)

Four children with lymphoproliferative malignant disease, two with acute lymphocytic leukemia in remission and two with Hodgkin's disease, were treated with a Thymic Hormone, THF, for disseminated varicella infecition. It is suggested that THF increased significantly the number of peripheral blood lymphocytes and T-rosette forming lymphocytes in 3 out of 4 children, who developed the varicella at the time of impaired cellular immunity. On the other hand, in the fourth child, with Hodgkin's disease, who had a normal number of T-rosettes, a decreased absolute number of lymphocytes as well as T-rosettes was observed over a course of 14 days THF treatment, although the percent of T-cells has not changed significantly. All of the four children recovered, including the child who was at high risk, with a marked lymphopenia, severe bilateral pneumonitis, hepatitis secondary infected skin lesions and psudomonas sepsis. It is indicated that THF therapy may restore the depressed cellular immunity in immunosuppressed children with malignant disease, and has its value as a supportive immunotherapy in life-threatening disseminated varicella infection.
On the Di-1-naphthylcarbene−Dibenzofluorene Rearrangement and the Ethylenization of Diarylcarbinols (1998)

Solution-spray flash vacuum thermolysis of di-1-naphthyldiazomethane (9) results in the formation of dibenzo[c,g]fluorene (12), formed via a carbene−carbene rearrangement of di-1-naphthylcarbene (10). The isomeric dibenzo[a,i]fluorene (11) claimed by Franzen and Joschek (Liebigs Ann. Chem. 1960, 633, 7) is not formed, and no dibenzofluorene is formed on thermolysis in boiling naphthalene. 11 is formed on dehydration of di-1-naphthylcarbinol (14) with phosphoric acid, but the claimed tetra-1-naphthylethylene (13) is not formed, and the so-called ethylenization of diarylcarbinols is cast in doubt generally. The compound previously believed to be 13 is 13-[di(1-naphthyl)methyl]dibenzo[a,i]fluorene (22). The alleged cleavage of 13 into two molecules of carbene 10 is unsubstantiated.