gebhart/patrepeval huggingface dataset:
Directed Printing and Reconfiguration of Thermoresponsive Silica‐pNIPAM Nanocomposites (2019)

Printing of polymeric composites into desired patterns and shapes has revolutionized small-scale manufacturing processes. However, high-resolution printing of adaptive materials that change shape in response to external stimuli remains a significant technical challenge. The article presents a new approach of printing thermoresponsive poly(N-isopropylacrylamide) into macroscopic structures that dynamically reconfigure in response to heating and cooling cycles. The printing process is performed using an external laser source, which enables thermal cross-linking of the polymer ink consisting of monomer, cross-linker, initiator, and inorganic nanoparticles. It is shown that the addition of silica nanoparticles enhances the mechanical properties of poly(N-isopropylacrylamide) while maintaining its thermoresponsiveness at micrometer-scale resolution, which otherwise is not feasible by extrusion-based three-dimensional printing techniques. It is demonstrated that spatial reconfiguration of the printed monolayers upon increasing temperature is governed by the local geometry, which enables mimicking the reconfiguration of plant leaves in a natural environment. The study lays a foundation for developing a new fabrication platform to print thermoresponsive structures that may find applications in biomedical implants, sensors, and other multi-responsive materials.
Integrated circuit cofired laminated ceramic package antenna (2002)

A novel concept to implement an antenna on an integrated circuit package is proposed for the single-chip solution of a wireless transceiver using deep submicron CMOS technology. The prototype antenna printed on a 40-pin dual-in-line cofired laminated ceramic package is experimentally studied at 3.45 GHz. The results show that the antenna has achieved a bandwidth of 25.1% and a gain of -2.0 dBi.
The long and winding road to the mitochondrial pyruvate carrier (2013)

The extraction of energy and biosynthetic building blocks from fuel metabolism is a fundamental requisite for life. Through the action of cellular enzymes, complex carbon structures are broken down in reactions coupled to the production of high-energy phosphates as in ATP and GTP as well as electron carriers such as NADH and FADH2. These processes traverse across compartments inside the cell in order to access specific enzymes and environments. Pyruvate is the end product of cytosolic glycolysis and has a variety of possible fates, the major one being mitochondrial oxidation. While this metabolite has been known to cross the inner mitochondrial membrane for decades, it is only recently that proteins necessary for this activity have been identified. This review will chronicle more than 40 years of research interrogating this critical process and will discuss some of the possible implications of this discovery for cancer metabolism.
Blood and milk prolactin and the rate of milk synthesis in women (1996)

In women, the concentration of prolactin in the plasma increases in response to nipple stimulation. This response has led to the assumption that prolactin influences the rate of milk synthesis. To investigate this hypothesis we have measured 24 h milk production, the short-term (between breastfeeds) rates of milk synthesis and the concentration of prolactin in the blood and breastmilk, from 1 to 6 months of lactation in eleven women. Over the long term, the 24 h milk production remained constant (means +/- S.E.M.): 708 +/- 54.7 g/24 h (n = 11) and 742 +/- 79.4 g/24 h (n = 9) at 1 and 6 months, respectively. The average short-term rate of milk synthesis (calculated from the increase in breast volume between breastfeeds; means +/- S.E.M.) did not change: 23 +/- 3.5 ml/h (n = 23) and 23 +/- 3.4 ml/h (n = 21) at 1 and 6 months, respectively. However, significant variation in the short-term rate of milk synthesis (from < 5.8 to 90 ml/h) was found both between breasts, measured concurrently (coefficient of variation, c.v. = 72%), and within the same breast, measured over consecutive breastfeeds (c.v. = 85%). The basal and suckling-stimulated concentrations of prolactin in the plasma (means +/- S.E.M.) declined from 1 to 6 months (basal, from 119 +/- 93 to 59 +/- 29 micrograms/1; peak, from 286 +/- 109 to 91 +/- 44 micrograms/l). In contrast, the concentration of prolactin in milk was much lower than in plasma, and decreased only slightly from 1 to 6 months of lactation (fore-milk, from 26.4 +/- 10 to 23.3 +/- 9.8 micrograms/l; hind-milk, from 18.9 +/- 5.1 to 13.2 +/- 6.3 micrograms/l). The concentration of prolactin in the milk was related to the degree of fullness of the breast, such that the concentration was highest when the breast was full. We found no relationship between the concentration of prolactin in the plasma and the rate of milk synthesis in either the short or long term. However, the relationship between the concentration of prolactin in milk and the degree of fullness of the breast suggests that the internalization of prolactin, after binding to its receptor, may be restricted when the alveolus is distended with milk.
Flame retardant performance of a modified aluminum trihydroxide with increased thermal stability (1995)

Abstract A modified form of aluminum trihydroxide has been synthesized that is thermally stable to approximately 350°C. Flame retardant and smoke generation performance in low melting temperature thermoplastics, such as polyvinyl chloride, polypropylene, and ethylene vinylacetate, are comparable to unmodified ATH. The increased thermal stability also allows this material to be used in thermoplastics with higher melting temperatures, such as polycarbonate, polybutylene terephthalate, and polyphenylene oxide, where ATH cannot be used.
Laminin-Induced Activation of Rac1 and JNKp46 Is Initiated by Src Family Kinases and Mimics the Effects of Skeletal Muscle Contraction (2007)

Binding of laminin to dystroglycan in the dystrophin glycoprotein complex causes signaling through dystroglycan-syntrophin-grb2-SOS1-Rac1-PAK1-JNK. Laminin binding also causes syntrophin tyrosine phosphorylation to initiate signaling. The kinase responsible was investigated here. PP2 and SU6656, specific inhibitors of Src family kinases, decreased the amount of phosphotyrosine syntrophin and decreased the level of active Rac1 in laminin-treated myoblasts, myotubes, or skeletal muscle microsomes. c-Src and c-Fyn both phosphorylate syntrophin, and inhibition of either with specific siRNAs diminishes the level of syntrophin phosphorylation. When the rat gastrocnemius was contracted, the level of Rac1 activation increased compared to that of the relaxed control muscle and Rac1 colocalized with beta-dystroglycan. Similar results were obtained when the muscle was stretched. Contracted muscle also contained more activated c-Jun N-terminal kinase, JNKp46. E3, an expressed protein containing only laminin domains LG4 and LG5, increased the rate of proliferation of myoblasts, and PP2 prevented cell proliferation. In addition, Src family kinases colocalized with activated Rac1 and with laminin-Sepharose in solid-phase binding assays. Thus, contraction, stretching, or laminin binding causes recruitment of Src family kinase to the dystrophin glycoprotein complex, activating Rac1 and inducing downstream signaling. The DGC likely represents a mechanoreceptor in skeletal muscle-regulating muscle growth in response to muscle activity. Src family kinases play an initiating and critical role.
Modeling evolution of behavioral resistance by an insect to crop rotation (2001)

Abstract Crop rotation has traditionally been a valuable method for managing pests, but now a serious insect pest of maize ( Diabrotica virgifera virgifera LeConte [Coleoptera: Chrysomelidae]) has developed behavioral resistance to rotation. A simple model of adult behavior and population genetics can explain how this resistance may have developed. This general model indicates that evolution may be caused by selection on a single gene for adult movement and that behavioral resistance only develops at high levels of rotation (>80% of plant landscape). In less diverse landscapes, crop rotation selects for the expansion of host preferences (polyphagy) by adults. More diverse landscapes may delay the evolution of resistance to crop rotation depending on the fitness costs and the nature of the genetic system.
Excimer laser treatment of corneal surface pathology: a laboratory and clinical study. (1991)

The argon fluoride excimer laser emits radiation in the far ultraviolet part of the electromagnetic spectrum (193 nm). Each photon has high individual energy. Exposure of materials or tissues with peak absorption around 193 nm results in removal of surface layers (photoablation) with extremely high precision and minimal damage to non-irradiated areas. This precision is confirmed in a series of experiments on cadaver eyes and the treatment of 25 eyes with anterior corneal disease (follow-up 6 to 30 months). Multiple zone excimer laser superficial keratectomy is considered the treatment of choice for rough, painful corneal surfaces. All patients in this group were pain-free postoperatively. Where good visual potential exists, ablation of a single axial zone is recommended and results in improved visual acuity and reduction of glare. A hyperopic shift was noted in this group.
Metadata Efficiency in a Comprehensive Versioning File System (2002)

Abstract : A comprehensive versioning file system creates and retains a new file version for every WRITE or other modification request. The resulting history of file modifications provides a detailed view to tools and administrators seeking to investigate a suspect system state. Conventional versioning systems do not efficiently record the many prior versions that result. In particular, the versioned metadata they keep consumes almost as much space as the versioned data. This paper examines two space-efficient metadata structures for versioning file systems and describes their integration into the Comprehensive Versioning File System (CVFS). Journal-based metadata encodes each metadata version into a single journal entry; CVFS uses this structure for inodes and indirect blocks, reducing the associated space requirements by 80%. Multiversion b-trees extend the per-entry key with a timestamp and keep current and historical entries in a single tree; CVFS uses this structure for directories, reducing the associated space requirements by 99%. Experiments with CVFS verify that its current-version performance is similar to that of non-versioning file systems. Although access to historical versions is slower than conventional versioning systems, checkpointing is shown to mitigate this effect.
Classification mechanism of an air classifier using centrifugal force. (Pat3). Effects of air flow rate and blade attitude angle on cut size. (1990)

The trajectories of particles thrown into a forced vortex type centrifugal air classifier are calculated numerically. The effects of the air flow rate and the blade attitude angle on the cut size are verified. The cut size is determined by the blade attitude angle as well as by the radial air flow rate. The lowest cut size can be reduced by increasing the blade attitude angle.
Aerodynamic Characteristics of a 4-foot-diameter Ducted Fan Mounted on the Tip of a Semispan Wing (1962)

Power, free-stream velocity, and duct angle of attack were varied at several wing angles of attack to define the aerodynamic characteristics of the ducted fan, wing, and of the ducted fan wing together. At large duct angles of attack, the inside of the upstream duct lip stalled causing a rapid change in the duct pitching moments and an accompanying increase in the power required. At low horizontal velocities, this lip stall would probably limit the rate of descent of a vehicle with a wing-tip-mounted ducted fan. During low-speed, level, unaccelerated flight (30 to 80 knots) it appeared that a vehicle, with a configuration similar to that examined, would require less power if it were supported by a wing and ducted fans than if it were supported only by ducted fans. (Author)
The Developmental Eye Movement (DEM) test and Cantonese‐speaking children in Hong Kong SAR, China (2010)

The DEM norms may be affected by differences in languages, cultures and education systems among different ethnicities. The norms of the DEM test are proposed for Cantonese-speaking children in Hong Kong SAR, China.
Implosion dynamics measurements at the National Ignition Facility (2012)

Measurements have been made of the in-flight dynamics of imploding capsules indirectly driven by laser energies of 1–1.7 MJ at the National Ignition Facility [Miller et al., Nucl. Fusion 44, 228 (2004)]. These experiments were part of the National Ignition Campaign [Landen et al., Phys. Plasmas 18, 051002 (2011)] to iteratively optimize the inputs required to achieve thermonuclear ignition in the laboratory. Using gated or streaked hard x-ray radiography, a suite of ablator performance parameters, including the time-resolved radius, velocity, mass, and thickness, have been determined throughout the acceleration history of surrogate gas-filled implosions. These measurements have been used to establish a dynamically consistent model of the ablative drive history and shell compressibility throughout the implosion trajectory. First results showed that the peak velocity of the original 1.3-MJ Ge-doped polymer (CH) point design using Au hohlraums reached only 75% of the required ignition velocity. Several capsule, hohlraum, and laser pulse changes were then implemented to improve this and other aspects of implosion performance and a dedicated effort was undertaken to test the sensitivity of the ablative drive to the rise time and length of the main laser pulse. Changing to Si rather than Ge-doped inner ablator layers and increasing the pulse length together raised peak velocity to 93% ± 5% of the ignition goal using a 1.5 MJ, 420 TW pulse. Further lengthening the pulse so that the laser remained on until the capsule reached 30% (rather than 60%–70%) of its initial radius, reduced the shell thickness and improved the final fuel ρR on companion shots with a cryogenic hydrogen fuel layer. Improved drive efficiency was observed using U rather than Au hohlraums, which was expected, and by slowing the rise time of laser pulse, which was not. The effect of changing the Si-dopant concentration and distribution, as well as the effect of using a larger initial shell thickness were also examined, both of which indicated that instabilities seeded at the ablation front are a significant source of hydrodynamic mix into the central hot spot. Additionally, a direct test of the surrogacy of cryogenic fuel layered versus gas-filled targets was performed. Together all these measurements have established the fundamental ablative-rocket relationship describing the dependence of implosion velocity on fractional ablator mass remaining. This curve shows a lower-than-expected ablator mass at a given velocity, making the capsule more susceptible to feedthrough of instabilities from the ablation front into the fuel and hot spot. This combination of low velocity and low ablator mass indicates that reaching ignition on the NIF will require &gt;20 μm (∼10%) thicker targets and laser powers at or beyond facility limits.
Neuropathology of Human Immunodeficiency Virus Infection (1991)

Neuropathology has defined novel HIV-specific diseases at tissue level: HIV encephalitis and HIV leukoencephalopathy. Both occur usually in the later stages of the AIDS infection and consistently demonstrate large amounts of HIV products. In contrast to this HIV-specific neuropathology, HIV-associated neuropathology features unspecific syndromes with disputed relation to HIV infection: myelin pallor, vacuolar myelopathy, vacuolar leukoencephalopathy, lymphocytic meningitis, and diffuse poliodystrophy. All types of neuropathology may contribute to clinical manifestation according to severity, extent, and distribution of lesions, but clinico-pathologic correlation may be poor in the individual case. Neuropathologic and other data suggest two major pathogenetic pathways of HIV-associated CNS damage: First, systemic and local increase of the virus load leads to HIV encephalitis or HIV leukoencephalopathy; this is corroborated by prominent HIV production within such lesions. Second, neuronotoxicity by HIV proteins or factors secreted from infected cells is supported by histological changes of diffuse poliodystrophy and by morphometric loss of frontocortical neurons.
Characterization of an Acyltransferase Capable of Synthesizing Benzylbenzoate and Other Volatile Esters in Flowers and Damaged Leaves of <i>Clarkia breweri</i>  (2002)

A cDNA encoding a protein with 456 amino acids whose sequence shows considerable similarity to plant acyltransferases was identified among 750 Clarkia breweri flower expressed sequence tags. The cDNA was expressed in Escherichia coli, and the protein produced was shown to encode the enzyme benzoyl-coenzyme A (CoA):benzyl alcohol benzoyl transferase (BEBT). BEBT catalyzes the formation of benzylbenzoate, a minor constituent of the C. breweri floral aroma, but it also has activity with a number of other alcohols and acyl CoAs. The BEBT gene is expressed in different parts of the flowers with maximal RNA transcript levels in the stigma, and no expression was observed in the leaves under normal conditions. However, BEBT expression was induced in damaged leaves, reaching a maximum 6 h after damage occurred. We also show here that a closely related tobacco (Nicotiana tabacum) gene previously shown to be induced in leaves after being challenged by phytopathogenic bacteria also has BEBT activity, whereas the most similar protein to BEBT in the Arabidopsis proteome does not use benzoyl CoA as a substrate and instead can use acetyl CoA to catalyze the formation of cis-3-hexen-1-yl acetate, a green-leaf volatile.
SDN-based solutions for Moving Target Defense network protection (2014)

Software-Defined Networking (SDN) allows network capabilities and services to be managed through a central control point. Moving Target Defense (MTD) on the other hand, introduces a constantly adapting environment in order to delay or prevent attacks on a system. MTD is a use case where SDN can be leveraged in order to provide attack surface obfuscation. In this paper, we investigate how SDN can be used in some network-based MTD techniques. We first describe the advantages and disadvantages of these techniques, the potential countermeasures attackers could take to circumvent them, and the overhead of implementing MTD using SDN. Subsequently, we study the performance of the SDN-based MTD methods using Cisco's One Platform Kit and we show that they significantly increase the attacker's overheads.
Chemical Rescue of a Mutant Enzyme in Living Cells (2006)

The restoration of catalytic activity to mutant enzymes by small molecules is well established for in vitro systems. Here, we show that the protein tyrosine kinase Src arginine-388-->alanine (R388A) mutant can be rescued in live cells with the use of the small molecule imidazole. Cellular rescue of a viral Src homolog was rapid and reversible and conferred predicted oncogenic properties. Using chemical rescue in combination with mass spectrometry, we confirmed six known Src kinase substrates and identified several new protein targets. Chemical rescue data suggest that cellular Src is active under basal conditions. Rescue of R388A cellular Src provided insights into the mitogen-activated protein kinase pathway. This chemical rescue approach will likely have many applications in cell signaling.
Coding Performance of Hybrid ARQ Schemes (2006)

We develop a unified performance metric and detailed analysis for hybrid automatic repeat request (HARQ) schemes based on incremental redundancy (IR) and Chase combining (CC). The general result is applicable to both symbol-based and bit-interleaved coded modulations, to HARQ processes based on rateless and fixed-rate mother codes, and IR schemes with and without a self-decodability restriction. The analysis shows that IR over CC coding gains tend to increase with the initial coding rate, but decrease with the signal-to-noise (SNR) variation between retransmissions. The gains can also be diminished when a fixed-rate mother code is used or when the self-decodability criterion is imposed. The theoretical prediction is compared with observed gains at 10% codeword error rates based on turbo-coding simulations. For scenarios with moderately varying SNR between retransmissions, the analytical model tracks actual simulation results very well. However, when the SNR varies widely and the systematic part of the turbo codeword is effectively erased, the CC scheme could, in fact, outperform some IR schemes. For these scenarios, which can be induced by fast time-varying fading or long retransmission delays, the self-decodable IR and the CC schemes prove to be more robust without much performance comprise. Finally, we discuss adaptive improvement to the conventional IR schemes based on the analytical result
Vinyl ether hydrolysis. 9. Isotope effects on proton transfer from the hydronium ion (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTVinyl ether hydrolysis. 9. Isotope effects on proton transfer from the hydronium ionA. J. Kresge, D. S. Sagatys, and H. L. ChenCite this: J. Am. Chem. Soc. 1977, 99, 22, 7228–7233Publication Date (Print):October 1, 1977Publication History Published online1 May 2002Published inissue 1 October 1977https://pubs.acs.org/doi/10.1021/ja00464a023https://doi.org/10.1021/ja00464a023research-articleACS PublicationsRequest reuse permissionsArticle Views482Altmetric-Citations76LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts