gebhart/patrepeval huggingface dataset:
Dynamic changes in EEG spectra during obstructive apnea in children (2000)

Children are less likely to demonstrate EEG arousal during obstructive sleep apnea (OSA) than adults. We hypothesized that changes in spectral EEG characteristics occur during REM-associated OSA in the absence of arousal. Eight snoring children underwent overnight polysomnography. OSA events during REM periods not associated with EEG or behavioral arousal were identified. EEG signals from C3A2 and C4A1 leads corresponding to 1) ≤10-sec epochs preceding OSA (PRE), 2) the obstructed period (OSA), and 3) ≤10-sec epochs following airflow resumption (POST) were subjected to fast Fourier transform (FFT) routines. Seventy-two isolated OSA, and 14 clusters of > 4 OSA events were analyzed. In single OSA, delta OSA amplitude was lower than in PRE (P < 0.01) and in POST (P < 0.001). Furthermore, POST delta amplitude was higher than PRE (P < 0.01). In contrast, in OSA clusters, the dynamic differences in delta amplitude disappeared after the second OSA. Reciprocal increases and decreases occurred for the theta frequency domain during OSA and post-OSA, while sigma and beta frequency power did not change. We conclude that during isolated OSA episodes without arousal, significant decreases in power selectively occur for delta frequency, and are followed by a rebound increase upon termination of apnea. The delta changes are progressively attenuated during repeated OSA. We postulate that delta changes may reflect ongoing adaptations in sleep pressure which are necessary to relieve the respiratory compromise, and may represent subtle evidence for arousal and consequent sleep fragmentation in children with OSAS. Pediatr Pulmonol. 2000; 29:359–365. © 2000 Wiley-Liss, Inc.
Effect of the addition of by-product ash of date palms on the mechanical characteristics of gypsum-calcareous materials used in road construction (2016)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation A. Khellou, A. Kriker, A. Hafssi, K. Belbarka, K. Baali; Effect of the addition of by-product ash of date palms on the mechanical characteristics of gypsum-calcareous materials used in road construction. AIP Conf. Proc. 25 July 2016; 1758 (1): 030005. https://doi.org/10.1063/1.4959401 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Effect of Macrolide Antibiotics on Neutrophil Function in Human Peripheral Blood (1997)

Since "small-dose and long-term" administration of erythromycin (EM) was shown to be efficacious in the treatment of chronic respiratory disease, the modulation of host defense responses by EM has attracted much attention. Although there is considerable controversy, it was recently demonstrated that EM activity reduces neutrophil function. In this study, we investigated the in vitro effects of the macrolides erythromycin (EM), a 14-membered ring, azithromycin (AZM), a 15-membered ring and rokitamycin (RKM), a 16-membered ring macrolide, on neutrophil function. The DCFH-DA method and cytochrome C method were used for assay of active oxygen generation and the Boyden-chamber method was used for assay of chemotaxis. EM and AZM, both of which have been shown to be clinically effective in the treatment of Diffuse panbronchiolitis (DPB), significantly suppressed active oxygen generation and chemotaxis of neutrophils at low concentrations equivalent to therapeutic doses (0.5 approximately 1.0 microgram/ml, p < 0.05), whereas the clinically ineffective RKM did not. The in vitro inhibitory effects of EM and AZM on active oxygen generation and chemotaxis of neutrophils demonstrated in the present study may be responsible for the therapeutic efficacy of these 14-membered and 15-membered ring macrolides in the treatment of DPB patients.
ACUTE QUADRIPLEGIC MYOPATHY WITH MYOSIN-DEFICIENT MUSCLE FIBRES AFTER LIVER TRANSPLANTATION (1999)

Patients with a complicated intra- and postoperative course of OLT who develop newly acquired acute muscle weakness should be suspected as having acute AQM with myosin-deficient muscle fibres. In this setting, differential diagnosis with other causes of weakness should be carried out, because the prognosis of this myopathy is good with early muscle rehabilitation therapy.
DNA Deformability as a Recognition Feature in the RevErb Response Element (2001)

Most nuclear receptors recognize the same consensus hexameric sequence, AGGTCA. An important question has been how the various members of this transcription factor family distinguish identity features in these closely related DNA sites. We determined structures from several crystal forms of the RevErb-DNA complex and analyzed the patterns of protein-DNA interactions and DNA distortions. We found a significant and consistent DNA distortion at a TA step directly preceding the first consensus 5'-AGGTCA-3' recognition sequence. Importantly, while this base-pair sequence is associated with RevErb's high-affinity sites, there are no sequence-specific contacts formed with the protein. Our study shows that RevErb relies instead on the intrinsic geometry and flexibility of this TA site to make the required fit between the proteins' independent major groove and minor groove binding interactions, which occur on both sides of the TA step. Our findings extend the description of response element discrimination to include a role for sequence-dependent DNA deformations and suggest how other monomeric members of this superfamily, such as NGFI-B, SF-1, and ROR, could also recognize unique geometric features in their DNA targets.
Vasopressin and desmopressin in central diabetes insipidus: adverse effects and clinical considerations. (2004)

The management of central diabetes insipidus has been greatly simplified by the introduction of desmopressin (DDAVP). Its ease of administration, safety and tolerability make DDAVP the first line agent for outpatient treatment of central diabetes insipidus. The major complication of DDAVP therapy is water intoxication and hyponatremia. The risk of hyponatremia can be reduced by careful dose titration when initiating therapy and by close monitoring of serum osmolality when DDAVP is used with other medications affecting water balance. Herein we review the adverse effects of DDAVP and its predecessor, vasopressin, as well as discuss important clinical considerations when using these agents to treat central diabetes insipidus.
Stem/progenitor cells derived from adult tissues: potential for the treatment of diabetes mellitus (2003)

In view of the recent success in pancreatic islet transplantation, interest in treating diabetes by the delivery of insulin-producing beta-cells has been renewed. Because differentiated pancreatic beta-cells cannot be expanded significantly in vitro, beta-cell stem or progenitor cells are seen as a potential source for the preparation of transplantable insulin-producing tissue. In addition to embryonic stem (ES) cells, several potential adult islet/beta-cell progenitors, derived from pancreas, liver, and bone marrow, are being studied. To date, none of the candidate cells has been fully characterized or is clinically applicable, but pancreatic physiology makes the existence of one or more types of adult islet stem cells very likely. It also seems possible that pluripotential stem cells, derived from the bone marrow, contribute to adult islet neogenesis. In future studies, more stringent criteria should be met to clonally define adult islet/beta-cell progenitor cells. If this can be achieved, the utilization of these cells for the generation of insulin-producing beta-cells in vitro seems to be feasible in the near future.
10W Mid-IR Holmium Pumped ZnGeP2 OPO (1998)

We report >low (10kHz) in the Mid-IR using a ZnGeP2 OPO driven by a 2micron laser with conversion and slope efficiencies of 50% and 63 % respectively.
Cannabinoid agonists inhibit the activation of 5-HT3 receptors in rat nodose ganglion neurons (1995)

1. Effects of cannabinoid agonists on the serotonin (5-HT)3 receptor-mediated current were investigated in rat nodose ganglion neurons. Anandamide, Win 55212-2, and CP55940 inhibited the 5-HT-induced current in a concentration dependent manner. IC50 values were 190, 310, and 94 nM for anandamide, Win 55212-2, and CP55940, respectively, and 1.6 microM for the nonpsychoactive enantiomer CP56667. This inhibition was slowly developing, noncompetitive, not dependent on membrane potential, and not affected by adenosine 3',5'-cyclic monophosphate (cAMP) analogues, guanosine-5'-O-(2-thiodiphosphate) (GDP-beta-S), and opioid receptor antagonist naltrexone. These data suggest that 5-HT3 receptor ion-channel is a site acted upon by cannabinoid agonists in the nervous system, and the action of cannabinoid agonists on 5-HT3 receptors may be a possible mechanism for some of the behavioral effects of cannabinoids, such as antiemesis and analgesia.
Development of Herpes Simplex Virus Vectors for Gene Transfer to the Central Nervous System (1994)

Advances in understanding the molecular basis of human disease in the past decade have led to the identification and cloning of genes responsible for certain heritable diseases of the central nervous system (CNS) as well as many of those encoding neurotransmitters, receptors, and growth factors which influence brain function. For example, the genes responsible for the neurodegenerative diseases amyotrophic lateral sclerosis (Rosen et al., 1993) and Huntington’s chorea (Goldberg, et al., 1993; Mac Donald et al., 1993) have recently been identified. Ongoing research promises to identify the genes primarily responsible for other more complex neurodegenerative disorders such as Alzheimer’s and Parkinson’s disease. Currently, many neurodegnerative diseases are not treatable. Even in cases where therapies exist, drugs which control symptoms may ultimately fail in the late stages of neurological disease in a considerable percentage of affected patients. For example, the administration of L-DOPA to Parkinson’s patients may even accelerate the decline in dopamine producing neurons. Other difficulties with traditional therapies are that the blood-brain barrier limits the delivery of systemically administered drugs into the brain parenchyma, and even drugs delivered by intraventricular injection penetrate poorly from the ventricular surface into the substance of the brain. Empediments to drug delivery and bioavailability are further complicated by the regional and cellular specialization that is characteristic of the brain. Direct targeting of the therapeutic product to specific brain regions or to cells within those regions may be required to overcome these limitations.
A QPSK/16-QAM OFDM-based 29.1Mbps LINC transmitter for Body Channel Communication (2012)

This paper proposed a high speed Body Channel Communication (BCC) transmitter under IF 20MHz, adopting the OFDM modulation and uneven multi-level LINC technique to reduce the power and complexity of the front-end circuit. The OFDM uses 16-QAM modulation to enhance the data rate and could select to use a convolutional code to increase the coding gain. The phase modulator in the LInear amplification with Nonlinear Component (LINC) transmitter uses not only clockgating scheme but also the glitch free protection. A detection and calibration DSP are also integrated to solve the LINC branch mismatch problem. Finally the capacitive sensing circuit provides the information of the connectivity between pastes and human. The chip is implemented by 90nm CMOS process, with die area 1.3mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . The maximum data rate could achieve 29.1Mbps. The total power is 1.925mW, resulting in 0.07nJ/bit transmission energy and 2.92 bps/Hz spectral efficiency.
Mechanism of DNA damage by chromium carcinogens (1996)

Oxochromimum(V) centers initiate DNA cleavage through a chromium(V)-phosphate diester intermediate by hydrogen abstraction from the C1′ position of the ribose sugar, leading to the formation of 5-methylene-2-furanone, 3′-phosphate terminus and DNA bases; by contrast a plasmid DNA (pUC19)is only nicked.
Studies on Abscisic Acid Part VI (1972)

Oxidation of methyl 2-trans-β-ionylideneacetate with N-bromosuccinimide afforded methyl 2-cis and trans-3'-hydroxy-β-ionylideneacetates. NaBH4 reduction of methyl 2-cis-3'-keto-β-ionylideneacetate and ethyl 4'-keto- α-ionylideneacetate gave methyl 2-cis-3'-hydrxy-β-ionylideneacetate and ethyl 4'-hydroxy-α-ionylideneacetate respectively. Further, methyl 4'-methoxy-epoxy-β-ionylideneacetate was prepared by epoxidation of methyl 4'-methoxy-β-ionylideneacetate. And then methyl 4'-hydroxy-1', 2'-dihydro-β-ionylideneacetate was synthesized from ethyl 4-keto-α-cyclogeranate. Growth inhibitory activities of the above compounds on rich seedlings were examined.
Clonal analysis of proliferation and differentiation of paired daughter cells: action of granulocyte-macrophage colony-stimulating factor on granulocyte-macrophage precursors. (1980)

Mouse granulocyte-macrophage progenitor cells were stimulated to divide by the granulocyte-macrophage colony-stimulating factor (GM-CSF). The two daughter cells were separated; one daughter was transferred to medium containing a high concentration of GM-CSF, the other to medium containing a low concentration. Daughter cell-derived clones in the presence of 2500 units of GM-CSF had average cell cycle times 3.5 +/- 2.5 (SEM) hr shorter than clones derived from the paired daughter cell stimulated by 50 units of GM-CSF. Final colony size achieved after stimulation by 50 units of GM-CSF was always smaller than that of colonies stimulated by 2500 units of GM-CSF. In 8 of 41 instances, colonies stimulated by 50 units of GM-CSF developed, or were composed only of, macrophage populations in contrast to the granulocytic composition of colonies derived from the paired daughter cell growing in the presence of 2500 units of GM-CSF. The regulator GM-CSF appears able to directly influence cell cycle times and the pathway of differentiation entered by many bipotential granulocyte-macrophage precursor cells.
Cellulosic nanocomposites. I. Thermally deformable cellulose hexanoates from heterogeneous reaction (2000)

Partially derivatized cellulose esters were prepared from dissolving-grade wood pulp fibers by reaction with a mixed p-toluene sulfonic/hexanoic anhydride system in a nonswelling (cyclohexane-based) reaction medium. The partially derivatized pulp fibers, which failed to undergo a significant change in shape or appearance during the modification, proved to be resistant to swelling (in water), were thermally deformable, and retained their biodegradability. Because X-ray diffractometry provided evidence for the presence of unsubstituted, ordered cellulose with cellulose I morphology, the thermally reshaped and consolidated sheets were found to consist of commingled mixtures of cellulose esters and cellulose I. The transparent or semitransparent consolidated sheets (depending on the degree of substitution) were found to represent composites in which cellulose I serves as a discontinuous inclusion that reinforces a continuous, partially ordered cellulose ester matrix. The composites, which revealed cohesive or adhesive failure at rupture, depending on the degree of substitution, had modulus values and tensile strengths as high as 1.3 GPa and 25 MPa, respectively. © 2000 John Wiley & Sons, Inc. J Appl Polym Sci 78: 2242–2253, 2000
The Plastidic Phosphoglucomutase from Arabidopsis. A Reversible Enzyme Reaction with an Important Role in Metabolic Control (2000)

An Arabidopsis cDNA (AtPGMp) encoding the plastidic phosphoglucomutase (PGM) predicted a 623-amino acid protein with an N-terminal sequence typical of a plastid signal peptide. Expression of a recombinant protein in Escherichia coli confirmed its enzyme activity. The recombinant enzyme had an apparent K(m) value of 98.5 microM and a V(max) of 4.48 micromol min(-1) (mg protein)(-1). The Calvin cycle intermediates fructose-1,6-bisphosphate and ribulose-1, 5-bisphosphate exerted an inhibitory effect on PGM activity, supporting its proposed involvement in controlling photosynthetic carbon flow. A point mutation was identified in the AtPGMp gene of the Arabidopsis pgm-1 mutant. The mutation in the mutant transcript generated a stop codon at about one third of the wild-type open reading frame, and thus rendered the polypeptide nonfunctional. Storage lipid analysis of the pgm-1 mutant seeds showed a 40% reduction in oil content compared with that of wild type. Our results indicate that plastidic PGM is an important factor affecting carbon flux in triacylglycerol accumulation in oilseed plants, most likely through its essential role in starch synthesis.
Feedback controls and G2 checkpoints: Fission yeast as a model system (1993)

Dependency relationships within the cell cycle allow cells to arrest the cycle reversibly in response to agents or conditions that interfere with specific aspects of its normal progression. In addition, overlapping pathways exist which also arrest the cell cycle in response to DNA damage. Collectively, these control mechanisms have become known as checkpoints. Analysis of checkpoints is facilitated by the fact that dependency relationships within the cell cycle, such as the dependency of mitosis on the completion of DNA synthesis, and the DNA damage checkpoint can be separated genetically. In fission yeast, Schizosaccharomyces pombe, the dependency of mitosis on prior completion of DNA synthesis is mediated through tyrosine-15 phosphorylation of the ubiquitous mitotic regulator p34cdc2. In contrast, the arrest of mitosis caused by DNA damage acts through a separate mechanism that appears to be independent of tyrosine-15 phosphorylation. Despite these distinct interactions with the mitotic machinery, the majority of fission yeast mutants that are deficient in mitotic arrest after DNA damage are also unable to respond to inhibition of DNA synthesis. In this essay we survey the current knowledge concerning feedback controls and checkpoints within fission yeast and relate this to information derived from other systems.
PPARγΔ5, a Naturally Occurring Dominant-Negative Splice Isoform, Impairs PPARγ Function and Adipocyte Differentiation (2018)

Peroxisome-proliferator-activated receptor γ (PPARγ) regulates glucose and lipid homeostasis, insulin signaling, and adipocyte differentiation. Here, we report the skipping of exon 5 as a legitimate splicing event generating PPARγΔ5, a previously unidentified naturally occurring truncated isoform of PPARγ, which lacks the entire ligand-binding domain. PPARγΔ5 is endogenously expressed in human adipose tissue and, during adipocyte differentiation, lacks ligand-dependent transactivation ability and acts as a dominant-negative isoform reducing PPARγ activity. Ligand-mediated PPARγ activation induces exon 5 skipping in a negative feedback loop, suggesting alternative splicing as a mechanism regulating PPARγ activity. PPARγΔ5 overexpression modifies the PPARγ-induced transcriptional network, significantly impairing the differentiation ability of adipocyte precursor cells. Additionally, PPARγΔ5 expression in subcutaneous adipose tissue positively correlates with BMI in two independent cohorts of overweight or obese and type 2 diabetic patients. From a functional perspective, PPARγΔ5 mimics PPARG dominant-negative mutated receptors, possibly contributing to adipose tissue dysfunction. These findings open an unexplored scenario in PPARG regulation and PPARγ-related diseases.
POPEYE: A simple and reliable collaborative working environment over mobile ad-hoc networks (2007)

Although useful and increasingly put into regular use, current collaborative working environment (CWE) solutions have several limitations and relevant needs for further research. Most systems address either rather traditional and rigid intra-organizational collaboration scenarios or, at the opposite, completely free and unstructured open communitiespsilas interactions. Emerging dynamic, flexible and ad-hoc collaboration schemes are hardly or not supported at all. Typically, explicit representation of the collaboration context, of workerspsila and teampsilas goals and the semantics of underlying business process are not addressed, and this makes difficult to ensure the context and process awareness, personalisation and collaboration support required in knowledge-rich interactions. Aiming at getting collaborative working environments free from rigid constraints, POPEYE considers P2P over wireless ad hoc groups, where fixed infrastructure is not a prerequisite, where virtual communities can emerge spontaneously and share data with the appropriate quality of service for business applications (persistence, synchronisation, security,....).
Serious Games for Language Learning: How Much Game, How Much AI? (2005)

Abstract. Modern computer games show potential not just for engaging and entertaining users, but also in promoting learning. Game designers employ a range of techniques to promote long-term user engagement and motivation. These techniques are increasingly being employed in so-called serious games, games that have nonentertainment
Repeated triggering of sporulation in <i>Bacillus subtilis</i> selects against a protein that affects the timing of cell division (2013)

Bacillus subtilis sporulation is a last-resort phenotypical adaptation in response to starvation. The regulatory network underlying this developmental pathway has been studied extensively. However, how sporulation initiation is concerted in relation to the environmental nutrient availability is poorly understood. In a fed-batch fermentation set-up, in which sporulation of ultraviolet (UV)-mutagenized B. subtilis is repeatedly triggered by periods of starvation, fitter strains with mutated tagE evolved. These mutants display altered timing of phenotypical differentiation. The substrate for the wall teichoic acid (WTA)-modifying enzyme TagE, UDP-glucose, has recently been shown to be an intracellular proxy for nutrient availability, and influences the timing of cell division. Here we suggest that UDP-glucose also influences timing of cellular differentiation.
The Lambda Method for the GNSS Compass (2006)

The Lambda Method for the GNSS CompassGlobal Navigation Satellite System carrier phase ambiguity resolution is the key to high precision positioning and attitude determination. In this contribution we consider the GNSS compass model. We derive the integer least-squares estimators and discuss the various steps involved in the ambiguity resolution process. This includes the method that has successfully been used in (Park and Teunissen, 2003). We emphasize the unaided, single frequency, single epoch case, since this is considered the most challenging mode of GNSS attitude determination.