gebhart/patrepeval huggingface dataset:
The Study on The Snake Venom (1999)

This study was carried out to invastigate the researches of Snake Venom and snakes which used in treatment 1. The fist literature that used the snake for treatment is Shin Nong Ben Cao Jing 2. Composition of Snake Venom is consist of Enzymatic proteins ; Phospholipase A(A1-2), Protease, L-amino acid oxidase etc, and Non-enzymatic proteins ; Crotamine(Cytolysin), Proteolytic factor(Hematoxin), Crotoxin(Neurotoxin) etc. 3. Main toxins in Snake Venom are Hematoxin, Cytolysin, Neurotoxin and Cardiotoxin. Lethal dose 50 value of Agkistrodon brevicaudus is /18g, Agkistrodon saxatilis is /18g, Agkistrodon ussuriensis is /18g, therefore Agkistrodon ussuriensis has strongist Snake Venom of all in Korea. 4. Pharmacological actions of Snake Venom are anticoagulation, thrombolytic function, hypotensor etc. 5. Systemic syndromes and signs after snakebite are Dizziness(25.7%), Vomitting(23.1%), Fever(22%), Visual disturbance(18%), Headache(17.7%) and Dyspnea(17.6%), etc. 6. Local syndrome and sign after snakebite is Discoloration(54.2%), Bleeding(20.2%), Bullae(10.7%), Skinulcer(10.8%), etc. 7. Pathological syndromes after snakebite are WBC increase, Urine protein, Urine sugar, Haematuria and elevation of S-GDT, S-GPT etc. These syndromes are leaded by Hematoxin and Cytolysin. 8. Complication signs after snakebite are Cellulitis, Gastritis, Lympoma, Abscess etc. 9. Common function of Viperidae(Agkistrodon acutus or Zaocys dhumnades etc) is expelling the wind(祛風), removing obstruction in the channels(通絡), antipastic function(止痙). And it is used in order to cure hemiparesis, hemiplegia, facial palsy and CVA disease, etc. 10. Using way of snake for medical treatment is various like Herbal alchol therapy, pill, powder and injection etc. The Study on the Snake Venom should be carried out continuously for using of medical treatment.
An allelic series of mutations in <i>Smad2</i> and <i>Smad4</i> identified in a genotype-based screen of <i>N</i> -ethyl- <i>N</i> - nitrosourea-mutagenized mouse embryonic stem cells (2002)

Using selectable genes as proof of principle, a new high-throughput genotype-based mutation screen in mouse embryonic stem (ES) cells was developed [Chen et al. (2002) Nat. Genet. 24, 314-317]. If expanded to nonselectable genes, this approach would allow one to proceed quickly from sequence to whole-animal phenotypes. Here data are presented showing that a screen of a cryopreserved library of clonal, germ line competent, N-ethyl-N-nitrosurea (ENU) mutagenized ES cells can identify a large series of allelic mutations in Smad2 and Smad4, two nonselectable genes of the transforming growth factor beta superfamily of signaling molecules. Whole animal phenotypic analyses of some of these alleles provided evidence for novel developmental processes mediated by these components of transforming growth factor beta signaling, demonstrating the utility of non-null alleles created by chemical mutagens. The accurately assessed mutation load of the ES cell library indicates that it is a valuable resource for developing mouse lines for genetic and functional studies. This methodology can conceptually be applied for the generation of an allelic series of subtle mutations at any locus of interest in the mouse.
Quality Markers Addressing Preanalytical Variations of Blood and Plasma Processing Identified by Broad and Targeted Metabolite Profiling (2013)

The response of the human plasma metabolome to preanalytical variation demands implementation of thorough quality assurance and QC measures to obtain reproducible and credible results from metabolomics studies. Metabolites identified as sensitive to preanalytics can be used to control for sample quality.
Solution structure of the Eps15 homology domain of a human POB1 (partner of RalBP1) (1999)

The solution structure of the Eps15 homology (EH) domain of a human POB1 (partner of RaIBP1) has been determined by uniform 13C/15N labeling and heteronuclear multidimensional nuclear magnetic resonance spectroscopy. The POB1 EH domain consists of two EF-hand structures, and the second one binds a calcium ion. In the calcium-bound state, the orientation of the fourth alpha-helix relative to the other helices of the POB1 EH domain is slightly different from that of calbindin, and much more different from those of calmodulin and troponin C, on the basis of their atomic coordinates.
Applications of kidney organoids derived from human pluripotent stem cells (2018)

The establishment of protocols to differentiate kidney organoids from human pluripotent stem cells provides potential applications of kidney organoids in regenerative medicine. Modeling of renal diseases, drug screening, nephrotoxicity testing of compounds, and regenerative therapy are attractive applications. Although much progress still remains to be made in the development of kidney organoids, recent advances in clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR-associated system 9 (Cas9) genome editing and three-dimensional bioprinting technologies have contributed to the application of kidney organoids in clinical fields. In this section, we review recent advances in the applications of kidney organoids to kidney disease modelling, drug screening, nephrotoxicity testing, and regenerative therapy.
Predicting Processor Performance (2004)

As part of an effort to keep an MIS curriculum in line with market demand, a sample of job postings from Monster.com was taken over a one year period. A list of most frequently requested skills and knowledge was created for jobs requiring a bachelor’s degree in information systems (IS) or management information systems (MIS). The results support the importance of verbal and written communications. The skills lists were further broken down into four traditional career paths: database, networking, systems analysis, and programming. A cluster analysis of the data revealed three basic skill groups: analysis, programming, and networking.
Solving the Third-Shift Problem in IC Piracy With Test-Aware Logic Locking (2015)

The increasing IC manufacturing cost encourages a business model where design houses outsource IC fabrication to remote foundries. Despite cost savings, this model exposes design houses to IC piracy as remote foundries can manufacture in excess to sell on the black market. Recent efforts in digital hardware security aim to thwart piracy by using XOR-based chip locking, cryptography, and active metering. To counter direct attacks and lower the exposure of unlocked circuits to the foundry, we introduce a multiplexor-based locking strategy that preserves test response allowing IC testing by an untrusted party before activation. We demonstrate a simple yet effective attack against a locked circuit that does not preserve test response, and validate the effectiveness of our locking strategy on IWLS 2005 benchmarks.
DETERMINATION OF NITROGEN IN METALLIC NITRIDES BY THE COMBUSTION METHOD (1935)

Applying the modified "Pregl-Dumas" method" for the determination. of nitrogen to the metallic nitrides, the author succeeded to make it as a accurate and more rapid one than the ordinary. As the nitrides of V, Cr, Si, Al etc. are not soluble in the ordinary acids, the lower values of contents are subsequently obtained by the "Distillation method"; and even by the " Vacuumfusion method, " there are some prejudices to the requirements not only of a complicated apparatus of high vacuum train, but a particular attentions in all durations. The author determined the nitrogen contents in Fe, Si, Al, Cr, Ni, Mn, Ti, V, Zr and their alloys of previously nitrided or not, and comparing these results to that of by the" Distillation method" the possibility of applying his method is certainly convinced. The nitrides of Fe, Mn, Ti and Zr gave the consistent results in both method, but the higher values are obtained by the author's method in the case of Si, Al, Ni, V, W and their alloys.
2D-to-3D photo rendering for 3D displays (2010)

We describe a computationally fast and effective approach to 2D-3D conversion of an image pair for the threedimensional rendering on stereoscopic displays of scenes\nincluding a ground plane. The stereo disparities of all the\nother scene elements (background, foreground objects) are\ncomputed after statistical segmentation and geometric localization of the ground plane. Geometric estimation includes camera self-calibration from epipolar geometry, and\nan original algorithm for the recovery of 3D visual parameters from the properties of planar homologies. Experimental results on real images show that, notwithstanding\nthe simple “theatrical” model employed for the scene, the\ndisparity maps generated with our approach are accurate\nenough to provide users with a stunning 3D impression of\nthe displayed scene, and fast enough to be extended to video\nsequences.
Dynamics of the Formation of Mixed Alkanethiol Monolayers:  Applications in Structuring Biointerfacial Arrangements (1998)

The control of molecular recognition at interfaces is of importance in many areas of bioelectronics and biocatalysis, particularly in the design of biosensors, where it may be desirable to be able to manipulate the degree of interaction between a protein and a metal surface. To develop appropriate models to study such phenomena, we have produced mixed monolayers on gold by the displacement of molecules from a previously formed, homogeneous self-assembled monolayer (SAM) of an alkanethiol (mercaptoethylamine) using a solution containing a thiol with a different functional headgroup (mercaptopropanol). The dynamics of the formation of the resultant surfaces were investigated using high-resolution X-ray photoelectron spectroscopy (XPS) to probe both the C(1s) and N(1s) environments, corresponding to the different species in the SAMs. To illustrate the application of such interfacial arrangements and to further understand their role in controlling protein-surface interactions, two systems were investigated: in the first instance, the electron transfer between the small redox protein, cytochrome c, and the mixed monolayers was investigated using cyclic voltammetry; second, the potential for producing surfaces with different amounts of immobilized antibodies was demonstrated using fluorescence microscopy.
Detection and Identification of Virulence Factors in <i>Yersinia pestis</i> Using SELDI ProteinChip <sup>®</sup> System (2001)

A rapid method for the detection, purification, and identification of proteins in bacterial extracts was developed using surface enhanced laser desorption/ionization (SELDI) ProteinChip technology. The effectiveness of this technique for monitoring the expression and identification of temperature- and calcium-regulated virulence factors of Yersinia pestis, the bacterium that causes human plague, is demonstrated. Y. pestis infection of its mammalian host is thought to be accompanied by rapid up-regulation of a number of genes following a shift from 26 degrees C (the temperature of the flea vector) to 37 degrees C (the temperature of the mammalian host). To model this process, Y. pestis cells were grown at 26 degrees C and 37 degrees C in a Ca(2+)-deficient medium. Through an initial protein profiling of the crude bacterial extract on strong anion exchange and copper affinity, ProteinChip arrays detected five proteins that were up-regulated and three proteins that were down-regulated at 37 degrees C. Two of the proteins predominately expressed at 37 degrees C were semi-purified in less than two days. The two proteins were identified as catalase-peroxidase and Antigen 4. Aside from its speed, a salient feature of the SELDI technique is the microgram amounts of crude sample required for analysis.
Prostanoid Receptors (2011)

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTProstanoid ReceptorsTakako Hirata* and Shuh NarumiyaView Author Information Department of Pharmacology, Kyoto University Graduate School of Medicine, Kyoto 606-8501, JapanE-mail: [email protected]Cite this: Chem. Rev. 2011, 111, 10, 6209–6230Publication Date (Web):August 5, 2011Publication History Received5 January 2011Published online5 August 2011Published inissue 12 October 2011https://pubs.acs.org/doi/10.1021/cr200010hhttps://doi.org/10.1021/cr200010hreview-articleACS PublicationsCopyright © 2011 American Chemical SocietyRequest reuse permissionsArticle Views3254Altmetric-Citations116LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Agonists,Antagonists,Cell signaling,Receptors,Rodent models Get e-Alerts
Transfection of rhabdomyosarcoma cells with connexin43 induces myogenic differentiation. (1997)

Normal cell physiological processes rely heavily on cues from the extracellular environment to coordinate the proper functioning of cellular activities. The intercellular communication that takes place through gap junctions in neighboring cells has been implicated in growth control and embryonic differentiation. Indeed, many tumorigenic cells induced to overexpress gap junction proteins exhibit increased differentiation and decreased cell proliferation. Although absent in mature skeletal muscle, studies have demonstrated that gap junctions are present during the early stages of myogenesis, indicating their possible role in muscle development. In our present study, we have attempted to induce a more differentiated phenotype in communication-deficient rhabdomyosarcoma cells. These tumorigenic human cells were transfected with cDNA encoding the gap junction protein connexin43 (Cx43) such that clones of varying expression were isolated. Intercellular communication as measured with dye passage assays was directly proportional to the level of Cx43 expressed, and in those cells expressing Cx43 at high levels, a marked increase in cell membrane fusion and myosin expression was observed. Furthermore, clones expressing Cx43 at high levels exhibited a significant reduction in growth rate when grown under nonadhesive conditions, an indication that their tumorigenicity had been reduced. This apparent increase in myogenic differentiation lends further evidence to the possible role of gap junctional coupling during developmental processes.
SIMPLIFIED EXTENDED COMPOSITE RIGHT/LEFT-HANDED TRANSMISSION LINE STRUCTURE FOR DUAL-BAND APPLICATIONS (2010)

A simplifled extended composite right/left-handed (SE- CRLH) transmission line (TL) is proposed for dual-band applications. The dual-band bandpass behavior is realized with a simplifled non-dual circuit with only two broadband balanced conditions. The dispersion relation and frequency response of SE-CRLH TL are analyzed by circuit analysis, Bloch-Floquet theorem, and full wave simulation. A demonstration of SE-CRLH structure is designed. The measurements are in agreement with simulations and theory.
Cellulose Degradation at Alkaline Conditions: Long-Term Experiments at Elevated Temperatures (2004)

The degradation of pure cellulose (Aldrich cellulose) and cotton cellulose at the conditions of an artificial cement pore water (pH 13.3) has been measured at 60 °C and 90 °C for reaction times between 1 and 2 years. The purpose of the experiments is to establish a reliable relationship between the reaction rate constant for the alkaline hydrolysis of cellulose (mid-chain scission), which is a slow reaction, and temperature. The reaction products formed in solution are analysed for the presence of the two diastereorners of isosaccharinic acid using high performance anion exchange chromatography combined with pulsed amperometric detection (HPAEC-PAD), other low-molecular weight aliphatic carboxylic acids using high performance ion exclusion chromatography (HPIEC) and for total organic carbon. The remaining cellulose solids are analysed for dry weight and degree of polyrnerisation. The degree of cellulose degradation as a function of reaction time is calculated based on total organic carbon and on the dry weight of the cellulose remaining. [...]<br /><br />\nDer Abbau von reiner Cellulose und Baumwolle wurde unter den Bedingungen eines künstlichen Zementporenwassers (pH 13.3) bei Temperaturen von 60 °C und 90 °C über Zeiträume von 1 bis 2 Jahren verfolgt. Ziel der Experimente ist es, einen verlässlichen Zusarnmenhang zwischen Temperatur und der Reaktionsgeschwindigkeitskonstante für die alkalische Spaltung, einer sehr angsamen Abbaureaktion der Cellulose, zu erhalten. Die löslichen Reaktionsprodukte wurden in ihrer Zusammensetzung auf die Konzentrationen der beiden Diastereornere der Isosaccharinsäure mittels Anionenaustauschchromatographie kombiniert mit gepulster amperometrischer Detektion (HPAEC-PAD), auf die Konzentrationen anderer kurzkettiger aliphatischer Carbonsauren mittels lonenausschlusschromatographie (HPIEC), sowie auf die totale Konzentration von organischern Kohlenstoff untersucht. In den unlöslichen Rückständen der Cellulose wurde die Kettenlange durch Messung des Polymerisationsgrades ermittelt. Der Abbaugrad der Cellulose als Funktion der Reaktionszeit wurde aufgrund der Resultate der Kohlenstoffrnessung, sowie des Gewichts der unlöslichen Rückstände berechnet. [...]
Heart valve surgery in 114 patients over the age of 60. (1973)

7 closed mitral valvotomies.
Effects of Natural Flavones and Flavonols on the Kinase Activity of Cdk5 (2004)

A number of natural and synthetic flavonoids have been assessed previously with regard to their effects on the activity of cyclin-dependent kinases (Cdk1 and -2) related to the inhibition of cell cycle progression. On the other hand, the Cdk5/p35 system is of major importance in neuronal migration phenomena and brain development, and its deregulation is implicated in neurodegenerative diseases, particularly Alzheimer's. Here we show that some natural flavonoids inhibit the activity of the Cdk5/p35 system in the micromolar range, while others are practically inactive. Ring B-unsubstituted and highly methoxylated flavones were inactive or gave irreproducible results, and 6-methoxyapigenin and 6-methoxyluteolin were the most potent Cdk5 complex inhibitors within this series, while the common flavonols kaempferol and quercetin showed intermediate behavior. The reported crystal structure of the Cdk5 complex with its activator p25 was used for docking studies, which also led to the identification of the two 6-methoxyflavones, kaempferol and quercetin, as well as the untested 6-methoxy derivatives of kaempferol and quercetin and the corresponding 6-hydroxy analogues as compounds exhibiting a good fit to the active site of the enzyme.
Sensor fault detection in nuclear power plants using multivariate state estimation technique and support vector machines. (2000)

No abstract prepared.
Development of a Novel RF Waveguide Vacuum Valve (2006)

The development of a novel rf waveguide vacuum valve is presented. The rf design is based on the use of TE0n modes of circular waveguides. In the device, the TE01 mode at the input is converted into a mixture of several TE0n modes which provide low-loss rf power transmission across the vacuum valve gap, these modes are then converted back into the TE01 mode at the output. There are a number of advantages associated with the absence of surface fields in the region of the valve: â¢ Possibility to use commercially available vacuum valves equipped with two specially designed mode converter sections. â¢ No necessity for an rf contact between these two sections. â¢ Increased potential for high power rf transmission. This technology can be used for all frequencies for which vacuum waveguides are used. In rectangular waveguides, mode converters from the operating mode into the TE01 mode and back again are necessary. Experimental results for the 30 GHz valves developed for the CLIC Test Facility 3 (CTF3) are presented showing in particular that the rf power transmission losses are below 1%. The rf waveguide vacuum valve installed in CTF3 has been tested with high power and is now in routine operation at power levels up to 40 MW and pulse length of 70 ns.
Surface finish metrology tutorial (1990)

\v4;,'v,# if '^1 'U;, () V ,,.
Low complexity impulse radio based UWB (IR-UWB) transceiver (2007)

In this paper, a RF transceiver for low complexity impulse-radio-based UWB system is presented. The proposed transceiver is based on noncoherent receiver and OOK modulation. The transmitter consists of a CMOS impulse generator chip of low power consumption, and a planar UWB filter. The module-based receiver is composed of LNAs, an envelope detector, and a comparator. For radiating and receiving UWB signals, a CPW-fed planar UWB antenna is developed. The frequency band of the transceiver is between 3.1 GHz and 4.9 GHz. The output signal of the receiver is a rectangular pulse of 13 ns duration and 3.3 V.
The Missing Link: Bridging The Patient–Provider Health Information Gap (2005)

Widespread adoption of information technology is now regarded as a pathway to improving health care and achieving the Institute of Medicine's highly regarded six aims for redesigning care. Achieving these aims requires fresh approaches to health system design, including continuous healing relationships between physicians and patients and provision of tools to help patients be more active participants in their own care. Personal health records (PHRs) might allow patients and providers to develop new ways of collaborating and provide the basis for broader transformation of the health care system. Federal policies can be key catalysts in accelerating PHR development and adoption.
An Adaptive Resource Sharing Platform for Internet Data Center (2013)

Internet applications are diverse, such as online web services, offline data analysis jobs and so on. To make different types of applications work effectively, many programming models and computing frameworks are designed, such as MapReduce, Dryad, and Hadoop. How to support the emerging applications and computing frameworks with high resource utilization is a serious challenge. In this paper, we present a resource sharing platform which can support different types of applications and computing frameworks by adopting a job-resource description protocol. To improve the resource utilization without impairing the performances of applications, we propose a job-resource matching algorithm, called JRMatching, which deploys those different types of jobs on one node hybridly to reduce resource fragments, and a mechanism to provide resources adaptively, which can reduce resource waste caused by fixed resource allocation. The experiments show that the performances of applications sharing resources in one node are close to running exclusively and the resource utilization of the internet data center also can be improved.