gebhart/patrepeval huggingface dataset:
Accelerating CUDA graph algorithms at maximum warp (2011)

Graphs are powerful data representations favored in many computational domains. Modern GPUs have recently shown promising results in accelerating computationally challenging graph problems but their performance suffered heavily when the graph structure is highly irregular, as most real-world graphs tend to be. In this study, we first observe that the poor performance is caused by work imbalance and is an artifact of a discrepancy between the GPU programming model and the underlying GPU architecture.We then propose a novel virtual warp-centric programming method that exposes the traits of underlying GPU architectures to users. Our method significantly improves the performance of applications with heavily imbalanced workloads, and enables trade-offs between workload imbalance and ALU underutilization for fine-tuning the performance. Our evaluation reveals that our method exhibits up to 9x speedup over previous GPU algorithms and 12x over single thread CPU execution on irregular graphs. When properly configured, it also yields up to 30% improvement over previous GPU algorithms on regular graphs. In addition to performance gains on graph algorithms, our programming method achieves 1.3x to 15.1x speedup on a set of GPU benchmark applications. Our study also confirms that the performance gap between GPUs and other multi-threaded CPU graph implementations is primarily due to the large difference in memory bandwidth.
An ultra-wideband high-dynamic range GPR for detecting buried people after collapse of buildings (2010)

An ultra wide band high dynamic range GPR radar - has been tested for buried victims detection. After a building collapse, for example due to an earthquake, the priority of search and rescue teams is to localize people trapped under debris. Several tools are available to help the detection of buried humans, such as micro-cameras, high sensitivity microphones, and so on. Many of these tools present some limitations such as low penetration depth and high susceptibility to external noises. In this paper the authors test the use of an Enhanced Ultra Wide Band (UWB), Continuous Wave Stepped Frequency (CW-SF) Ground penetrating radar as rescue equipment. The radar has been experimented both in controlled environment, and in a real test site, at the Fire-fighters Station of Pisa, Italy.
In-Situ Recovery of Suspended Sediments from Streams (1985)

A simple, low-cost, mechanical vacuum-filtering system for collecting suspended stream sediment has been developed. The system is comprised of a polypropylene hand pump, a polypropylene suction nozzle funnel, and a two-liter Erlenmeyer polypropylene flask. The system is light in weight and can be used effectively in inaccessible areas to collect suspended matter from streams for geochemical exploration, for sediment mass-balance and chemical mass-balance investigations, for provenance studies (via mineralogy), and for environmental geochemical research.
Modulation optimization under energy constraints (2004)

We consider radio applications where the nodes operate on batteries so that energy consumption must be minimized while satisfying given throughput and delay requirements. In this context, we analyze the best modulation strategy to minimize the total energy consumption required to send a given number of bits. The total energy consumption includes both the transmission energy and the circuit energy consumption. We show that for both MQAM and MFSK the transmission energy decreases with the BT/sub on/ product while the circuit energy consumption increases with T/sub on/, where B is the modulation bandwidth and T/sub on/ is the transmission time. Thus, in short-range applications where the circuit energy consumption is nonnegligible compared with the transmission energy, the total energy consumption is minimized by using the maximum system bandwidth along with an optimized transmission time T/sub on/. We derive this optimal T/sub on/ for MQAM and MFSK modulation in both AWGN channels and Rayleigh fading channels. Our optimization considers both delay and peak-power constraints. Numerical examples are given, where we exhibit up to 68% energy savings over modulation strategies that minimize the transmission energy alone.
Ratchetlike Motion of a Shaken Drop (2009)

We study the motion of a drop lying on a plate simultaneously submitted to horizontal and vertical harmonic vibrations. The two driving vibrations are adjusted to the same frequency, and, according to their relative amplitude and phase difference DeltaPhi, the drop experiences a controlled directed motion with a tunable velocity. We present a simple model putting in evidence the underlying mechanism leading to this ratchetlike motion of the drop. Our model includes the particular case DeltaPhi=pi corresponding to the climbing of a drop on a vertically vibrated inclined substrate, as recently observed by Brunet et al. [Phys. Rev. Lett. 99, 144501 (2007)10.1103/PhysRevLett.99.144501]. This study gives insights in the fundamental issue of wetting dynamics and offers new possibilities of controlled motion in droplet microfluidics applications.
Surfactant‐Assisted Growth of Novel PbS Dendritic Nanostructures via Facile Hydrothermal Process (2003)

3D PbS dendritic nanostructures (see Figure) have been fabricated by a facile hydrothermal method in the presence of N ‐cetyl‐ N , N , N ‐trimethyl‐ammonium bromide (CTAB). Both CTAB and thiourea play important roles in the formation of well‐defined PbS dendrites. X‐ray diffraction, electron diffraction, and high‐resolution transmission electron microscopy results show that the PbS nanostructure is a 3D dendrite of a single crystal.
Bacterial copper‐ and zinc‐cofactored superoxide dismutase contributes to the pathogenesis of systemic salmonellosis (1997)

Copper/zinc-cofactored superoxide dismutase ([Cu,Zn]-SOD) has been found in the periplasm of many bacterial species but its biological function is unknown. Here we report the cloning and characterization of sodC, encoding [Cu,Zn]-SOD, from Salmonella typhimurium. The predicted protein sequence shows only 58% identity to Escherichia coil SodC, and from this its chromosomal location and its immediate proximity to a phage gene, sodC, in Salmonella is speculated to have been acquired by bacteriophage-mediated horizontal transfer from an unknown donor. A sodC mutant of S. typhimurium was unimpaired on aerobic growth in rich medium but showed enhanced sensitivity in vitro to the microbicidal action of superoxide. S. typhimurium, S. choleraesuis and S. dublin sodC mutants showed reduced lethality in a mouse model of oral infection and persisted in significantly lower numbers in livers and spleens after intraperitoneal infection, suggesting that [Cu,Zn]-SOD plays a role in pathogenicity, protecting Salmonella against oxygen radical-mediated host defences. There was, however, no observable difference compared with wild type in the interaction of sodC mutants with porcine pleural, mouse peritoneal or J774 macrophages in vitro, perhaps reflecting the hierarchical capacity of different macrophage lines to kill Salmonella, the most efficient overwhelming the proposed protective effect of periplasmic SOD.
Expression of transforming growth factor-beta receptors during hyperoxia-induced lung injury and repair (1997)

Lung injury and repair processes involve many cellular activities, including cell growth, differentiation, and remodeling of extracellular matrix components. Transforming growth factor-beta (TGF-beta) is a major class of signaling peptide growth factors regulating these cellular activities. Type I (T beta RI) and type II (T beta RII) receptors for TGF-beta are transmembrane serine/threonine kinases that are essential for TGF-beta signaling. To gain insight into the possible molecular mechanisms of lung injury and repair, we investigated the expression of T beta RI and T beta RII in an acute hyperoxia-induced model of lung injury and repair. Localization of message expression of T beta RI and T beta RII in oxygen-exposed rat lung tissue was analyzed by using in situ hybridization. T beta RI mRNA expression was found in the interstitium, capillaries, and the alveolar septa of rat lungs exposed for 60 h to 100% oxygen. The distribution of T beta RII mRNA in oxygen-exposed rat lung tissue overlapped the localization of T beta RI mRNA. Temporal changes of T beta RI and T beta RII mRNA expressions in rat lung during hyperoxic exposure and repair were examined by Northern analysis. We found that expression of T beta RI was upregulated in adult rats undergoing prolonged exposure to 100% oxygen, and the increase of T beta RI expression persisted during 2 wk of repair of lung injury. The pattern of T beta RII expression during hyperoxic exposure and repair was distinct from that of T beta RI. The expression of T beta RII increased with a peak at 3 days postexposure and then declined after 7 days of repair. Changes of T beta RI and T beta RII protein expressions in rat lung during hyperoxic exposure and repair were examined further by Western blot analysis, which correlated with the mRNA expression. The results suggest that T beta RI and T beta RII may play important roles during the lung injury and repair by mediating signaling activity of TGF-beta and may regulate interactions between the mesenchyme and the epithelium.
Human Cytomegalovirus Encoded Homologs of Cytokines, Chemokines and their Receptors: Roles in Immunomodulation (2012)

Human cytomegalovirus (HCMV), the largest human herpesvirus, infects a majority of the world's population. Like all herpesviruses, following primary productive infection, HCMV establishes a life-long latent infection, from which it can reactivate years later to produce new, infectious virus. Despite the presence of a massive and sustained anti-HCMV immune response, productively infected individuals can shed virus for extended periods of time, and once latent infection is established, it is never cleared from the host. It has been proposed that HCMV must therefore encode functions which help to evade immune mediated clearance during productive virus replication and latency. Molecular mimicry is a strategy used by many viruses to subvert and regulate anti-viral immunity and HCMV has hijacked/developed a range of functions that imitate host encoded immunomodulatory proteins. This review will focus on the HCMV encoded homologs of cellular cytokines/chemokines and their receptors, with an emphasis on how these virus encoded homologs may facilitate viral evasion of immune clearance.
A strong version of the redundancy-capacity theorem of universal coding (1995)

The capacity of the channel induced by a given class of sources is well known to be an attainable lower bound on the redundancy of universal codes with respect to this class, both in the minimax sense and in the Bayesian (maximin) sense. We show that this capacity is essentially a lower bound also in a stronger sense, that is, for "most" sources in the class. This result extends Rissanen's (1984, 1986) lower bound for parametric families. We demonstrate the applicability of this result in several examples, e.g., parametric families with growing dimensionality, piecewise-fixed sources, arbitrarily varying sources, and noisy samples of learnable functions. Finally, we discuss implications of our results to statistical inference.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Isopentenyl-diphosphate isomerase: inactivation of the enzyme with active-site-directed irreversible inhibitors and transition state analogs (1988)

Seven analogues of isopentenyl diphosphate (1) and dimethylallyl diphosphate (2) containing fluorine, epoxy, and ammonium functional groups irreversibly inhibited isopentenyl-diphosphate:dimethylallyl-diphosphate isomerase (EC 5.3.3.2) from the mold Claviceps purpurea. Inactivation kinetics, substrate protection studies, and labeling experiments demonstrated that the analogues interacted stoichiometrically with the active site of the enzyme. Radioactive enzyme-inactivator complexes were stable to extended dialysis and treatment with chaotropic reagents. The complexes resulting from inactivation of isomerase by 3-(fluoromethyl)-3-buten-1-yl diphosphate (3) and 3,4-epoxy-3-methyl-1-butyl diphosphate (4) were also stable to ion-exchange chromatography and gel electrophoresis. Stoichiometric release of fluoride ion occurred during inactivation of isomerase with 3. This observation is consistent with SN2 or SN2' displacement of fluorine by an active-site nucleophile with concomitant covalent attachment of the inactivator to the enzyme. 2-(Dimethylamino)ethyl diphosphate (9) formed a stable noncovalent complex with isomerase with Kdis less than 1.2 x 10(-10) M. The enzyme-inhibitor complex was stable in 6 M urea, but the inhibitor was partially released upon treatment with SDS and 2-mercaptoethanol at 37 degrees C for 1 h. The results indicate that 9 is a transition-state/reactive intermediate analogue where the positively charged ammonium group mimics a tertiary carbocationic species in the enzyme-catalyzed reaction.
25 GHz spaced DWDM 160×10.66 Gbit/s (1.6 Tbit/s) unrepeatered transmission over 380 km (2005)

Unrepeatered transmission of 160 25 GHz spaced channels at 10 Gbit/s over 380 km is demonstrated. The combination of recent advanced technologies, such as DWDM multiplexing/demultiplexing, large pump power, remote amplification, in-line filtering and FEC, allow this record transmission to be achieved.
Insulin: Appropriate Placement in the Portal Vein (2014)

Subcutaneous insulin administration in the diabetic patient causes peripheral hyperinsulinemia, which contributes to vascular disease, hyperlipidemia and coagulation abnormalities. In the non diabetic patient, insulin is released from the pancreas into the portal system. The majority of this endogenous insulin is taken up by the liver in the first pass so that portal insulin exceeds peripheral insulin. Avoiding peripheral hyperinsulinemia requires that insulin be given orally or administered intra-portally; the latter we have done in diabetic dogs. We propose portal insulin placement in diabetes as physiologic and appropriate in an effort to avoid peripheral hyperinsulinemia and its sequellae.
Accidental epinephrine auto-injector-induced digital ischemia reversed by phentolamine digital block (1995)

The use of epinephrine-containing auto-injectors as a prescription medication for treating routine to severe anaphylactic reactions is now widely accepted. Associated with this trend is an increasing number of accidental injections of epinephrine into digits, causing severe vasoconstriction and the risk of ischemic necrosis. When epinephrine is accidentally discharged into a digit, ischemic skin necrosis resulting from the alpha-adrenergic blocking effects of this agent can lead to the need for multiple operations, wound infection, and even loss of the digit. The alpha-adrenergic blocking characteristics of phentolamine administered by a variety of methods have proved effective in reversing the effects of epinephrine in these cases. The authors urge that the described treatment protocol become more widely disseminated among primary care and emergency physicians.
Augmenting Self-Driving with Remote Control (2018)

Self-driving or autonomous vehicle systems are being designed over the world with increasing success in recent years. In spite of many advances so far, it is unlikely that such systems are going to ever achieve perfect accuracy under all conditions. In particular, occasional failures are anticipated when such vehicles encounter situations not observed before, or conflicting information is available to the system from the environment. Under such infrequent failure scenarios, the research community has so far, considered two alternatives -- to return control to the driver in the vehicle, which has its own challenges and limitations, or to attempt to safely "park" the vehicle out of harm's way. In this paper, we argue that a viable third alternative exists -- on failure of the self-driving function in the vehicle, the system could return control to a remote human driver located in response centers distributed across the world. This remote human driver will augment the self-driving system in vehicles, only when failures occur, which may be due to bad weather, malfunction, contradiction in sensory inputs, and other such conditions. Of course, a remote driving extension is fraught with many challenges, including the need for some Quality of Service guarantees, both in latency and throughput, in connectivity between the vehicles on the road and the response center, so that the remote drivers can react efficiently to the road conditions. To understand some of the challenges, we have set up real-time streaming testbed and evaluate frame latency with different parameter settings under today's LTE and Wi-Fi networks. While additional optimization techniques can be applied to further reduce streaming latency, we recognize that significant new design of the communication infrastructure is both necessary and possible.
A strongly consistent procedure for model selection in a regression problem (1989)

We consider the multiple regression model Yn= Xnβ+ En, where Yn and En are n-vector random variables, Xn is an n×m matrix and β is an m-vector of unknown regression parameters. Each component of β may be zero or nonzero, which gives rise to 2m possible models for multiple regression. We provide a decision rule for the choice of a model which is strongly consistent for the true model as n →∞. The result is proved under certain mild conditions, for instance without assuming normality of the distribution of the components of En.
Identification of Tumor Antigens as Targets for Novel Antitumor Therapies (2013)

Cancer is still one of the leading causes of death at present. The development of immunotherapies based on the identification of tumor antigens provides a promising option of cancer therapy. Tumor antigens are the targets that could be recognized by T cells or antibodies and thus elicit immune response in cancer patients. Since tumor antigens are exclusively expressed or over expressed on tumor cells, the immune responses against tumor antigens would only destroy tumor cells but not normal cells. Cancer immunotherapies discussed in this chapter refer to therapeutic monoclonal antibodies, adoptive T cell therapy, and therapeutic vaccines. With the superiority of high specificity, cancer immunotherapies may act as a personalized treatment against cancer to overcome the immune suppression environment of cancer patients as well as the unexpected side effects.
Low-damaged p-type doping of MoS <sub>2</sub> using direct nitrogen plasma modulated by toroidal-magnetic-field (2019)

Low damaged doping of two-dimensional (2D) materials proves to be a significant obstacle in realizing fundamental devices such as p-n junction diodes and transistors due to its atom layer thickness. In this work, the defect formation energy and p-type conduction behavior of nitrogen plasma doping are investigated by first principle calculation. Low damaged substitutional p-type doping in MoS<sub>2</sub> using low energy nitrogen plasma composed of N<sup>+</sup> and N<sub>2</sub> <sup>+</sup> is achieved by a novel toroidal magnetic field (TMF). The TMF helps to raise the concentration of N<sub>2</sub> <sup>+</sup> ions at low RF power condition. The electrical characteristics of double-layer MoS<sub>2</sub> field-effect transistors (FETs) clearly show an efficient p-type doping behavior. Atomic force microscope is applied to verify the slight damage in MoS<sub>2</sub>. X-ray photoelectron spectroscopy, photoluminescence and Raman spectroscopy confirm the effective p-type doping characteristic with weak damage. These findings provide a low damage technology for efficient carrier modulation of MoS<sub>2</sub> and other homogeneous TMDC materials, which overcomes barriers in developing 2D electronic and optoelectronic devices.
Abstract 1396: Mitigation Of Cardiac Injury By Sulfaphenazole, A CYP2C9 Inhibitor Through Involvement Of Inducible Nitric Oxide Synthase (iNOS) in Post-ischemic Heart (2007)

Cytochrome P450 enzymes play a significant role in ischemia-reperfusion (I/R) injury. Sulfaphenazole (SFZ), a potent CYP2C9 inhibitor, is known to reduce I/R injury. However, the mechanism of its cardioprotective effects and the role of nitric oxide (NO) is not clear. Objective : Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are important mediators of I/R injury. The objective of this study was to determine how SFZ treatment modulates myocardial tissue oxygenation (pO 2 ) and RNS generation in vivo . Methods: Myocardial infarction was induced in rats by ligating the left anterior descending coronary artery (LAD) for 30 min, followed by 24 h of reperfusion. The study was divided into 4 groups: Untreated I/R control, SFZ, L-NAME, and SFZ+L-NAME. L-NAME (100 mg/kg/day), a nitric oxide synthase inhibitor, was given orally for 3 days prior to LAD ligation. SFZ (1.5 mg/kg, ip) was injected 30 min prior to LAD ligation. Oxygen-sensing crystals were implanted into the LV wall and the rat was placed in an L-band (1.2 GHz) electron paramagnetic resonance (EPR) spectrometer for measurement of myocardial tissue pO 2 during I/R injury. Hemodynamic data was collected with a microtip catheter. Infarct size was measured after 24 h of reperfusion. Superoxide generation was determined by dihydroethidium fluorescence imaging. Immunohistological staining was performed for nitrotyrosine and iNOS. Results: After LAD ligation, pO 2 decreased from 18 mmHg baseline to <2 mmHg. At reperfusion, there was a significant myocardial hyperoxygenation in SFZ-treated rats compared to control group (45.0±1.3 vs. 34.0±2.0 mmHg, P<0.05). In L-NAME and L-NAME+SFZ-treated rats, there was a significant reduction in pO 2 (24.0±1.6 and 26.0±2.3 mmHg, respectively). Compared to control, SFZ treatment significantly improved the left ventricular developed pressure (94.0±4.7 vs. 69.0±6.5 mmHg, P<0.05), decreased infarct size % (35.0±4.2 vs. 16.0±2.5, P<0.05), decreased superoxide generation and nitrotyrosine production. Conclusions: These findings demonstrate that SFZ may provide potent cardioprotection by attenuating post-ischemic ROS and RNS generation, and could serve as an attractive adjuvant therapy in the clinical setting of myocardial I/R injury.