gebhart/patrepeval huggingface dataset:
Piperacillin-tazobactam plus amikacin versus ceftazidime plus amikacin as empiric therapy for fever in granulocytopenic patients with cancer. The International Antimicrobial Therapy Cooperative Group of the European Organization for Research and Treatment of Cancer (1995)

Gram-positive bacteria have become the predominant infecting organisms in granulocytopenic cancer patients. Empiric antibiotic regimens used in febrile neutropenic patients often include an extended-spectrum cephalosporin, but the response to therapy in gram-positive coccal bacteremia has been unsatisfactory. Thus, new antibiotics with better activity against gram-positive bacteria should be tested. The objective of this prospective randomized controlled study was to evaluate and compare the efficacy and tolerance of piperacillintazobactam plus amikacin with that of ceftazidime plus amikacin, the standard regimen of the International Antimicrobial Therapy Cooperative Group of the European Organization for Research and Treatment of Cancer, in the empiric treatment of febrile granulocytopenic cancer patients. A total of 858 episodes were eligible for this study, and 706 episodes were assessable for efficacy. The antibiotic treatment was successful in 210 (61%) of 342 episodes in the piperacillin-tazobactam-amikacin group compared with 196 (54%) of 364 episodes treated with ceftazidime plus amikacin (P = 0.05). The time to defervescence was significantly shorter (P = 0.01) and the time to failure was significantly longer (P = 0.02) in the piperacillin-tazobactam-amikacin group. A significant difference in response to bacteremic infections between the two patient groups was found: piperacillin-tazobactam plus amikacin was successful in 40 of 80 episodes (50%), and ceftazidime plus amikacin was successful in 35 of 101 episodes (35%) (P = 0.05). A multivariate analysis showed that the probability of failure was significantly greater with ceftazidime plus amikacin than with piperacillin-tazobactam plus amikacin (P = 0.02). This trial suggests that piperacillin-tazobactam plus amikacin is more effective than ceftazidime plus amikacin for the empiric treatment of fever and bacteremia in granulocytopenic cancer patients. Although cutaneous reaction was more frequently associated with piperacillin-tazobactam plus amikacin than with ceftazidime-amikacin, this unwanted effect was relatively mild and its incidence was comparable to that of other penicillin compounds.
Ultrathin CoPt-pinned current perpendicular to the plane spin valves (2005)

The magnetics and magnetotransport of current perpendicular to the plane (CPP) giant magnetoresistive (GMR) spin valves utilizing thin CoPt hard magnet pinning layers on Cr seed layers are investigated. 50-Å-thick CoPt18 films grown on &gt;20Å Cr seed layers exhibit a coercivity of ∼1.5kOe and a resistivity of 31μΩcm. The low critical thickness of the CoPt hard magnet compared to IrMn or PtMn antiferromagnets makes it an attractive pinning material for small gap CPP sensors required for high magnetic recording densities. Furthermore, CoPt∕Ru∕CoFe trilayers exhibit strong antiparallel coupling and the low CoPt resistivity minimizes parasitic resistance yielding a higher magnetoresistance. Moreover, free layers with coercivities and coupling fields in a range of 5–10 Oe have been measured, demonstrating that free layer softness does not suffer from the proximity to the CoPt hard magnet due to the relatively thick spacer layers compatible with CPP GMR sensors. In particular we deposited CoPt18 pinned antiferromagnetically coupled spin with a variety of reference layers. The films were patterned into pillars with diameters ranging from 50 to 200 nm by using a combination of electron beam lithography and ion milling. The devices exhibit a magnetoresistance up to 3.6% and a resistance area product of only 20mΩμm2.
IMMERSIVE NEUROFEEDBACK - A New Paradigm (2011)

Healthcare organizations continue to pursue ways of offering higher-quality care to face the demand and expectations in promoting and maintaining health and in disease prevention. Currently, in neuroscience, there is an undergoing paradigm shift towards immersive neurofeedback mechanism. This will improve the user’s (or patient’s) ability to control brain activity, medical diagnoses, and rehabilitation of neurological or psychiatric disorders. Indeed, several psychological and medical studies have confirmed that virtual immersive activity is enjoyable, stimulating, and can have a healing effect. The new paradigm consists of an immersive room and three input devices: Emotiv headset (wireless non-invasive acquisition of brain waves), Kinect camera (gesture recognition), and wireless microphone (voice/speech recognition); towards immersive treatment and better quality health system in the near future.
Negative pressure wound therapy for management of the surgical incision in orthopaedic surgery (2013)

There is a rapidly emerging literature on the effect of NPWT on the closed incision. Initiated and confirmed first with a randomised controlled trial in orthopaedic trauma surgery, studies in abdominal, plastic and vascular surgery with high rates of complications have been reported recently. The evidence from single-use NPWT devices is accumulating. There are no large randomised studies yet in reconstructive joint replacement. Cite this article: Bone Joint Res 2013;2:276-84.
Developing Web services (2002)

Web based application developers are attempting to move towards Web services as a mechanism for developing component based Web applications. Unfortunately, traditional tools and development models are inadequately architected to meet the rapidly evolving needs for the future of scalable Web services. Today's Web services development model is mired with complexity as traditional tools and technologies, focused on client-server application development, are ill suited. The author examines the challenges of today's Web service development model.
In Vivo and in Vitro Degradation of Glucagon-Like Peptide-2 in Humans1 (2000)

Glucagon-like peptide-2 (GLP-2), an intestinal product of glucagon gene expression which induces intestinal growth in mice, has been proposed as a treatment for intestinal insufficiency. GLP-2 is metabolized extensively by dipeptidyl peptidase IV (DPP-IV) in rats, but less is known about its fate in humans. Therefore, GLP-2 metabolism was investigated in healthy volunteers after 1) a 500-Cal mixed meal (n = 6), 2) iv infusion of synthetic human GLP-2 (0.8 pmol/kg x min; n = 8), 3) a sc bolus injection (400 microg; n = 9), and 4) in vitro incubation in plasma and blood (1,000 pmol/L; n = 4). GLP-2 concentrations were determined by N-terminal RIA measuring only intact GLP-2, side-viewing RIA measuring intact and degraded forms [e.g. GLP-2-(3-33) arising from DPP-IV degradation], and high performance liquid chromatography (HPLC). Meal ingestion elevated plasma GLP-2 (intact, 16 +/- 3 to 73 +/- 10 pmol/L at 90 min), and HPLC revealed two immunoreactive components: intact GLP-2 (57 +/- 2%) and GLP-2-(3-33). GLP-2 infusion increased plasma levels [intact, 9 +/- 4 to 131 +/- 11 pmol/L; total, 23 +/- 7 to 350 +/- 18 pmol/L; the differences represent GLP-2-(3-33)]. The elimination t(1/2) values were 7.2 +/- 2 min (intact GLP-2) and 27.4 +/- 5.4 min [GLP-2-(3-33)], and MCRs were 6.8 +/- 0.6 and 1.9 +/- 0.3 mL/kg x min, respectively. Subcutaneous injection increased intact GLP-2 to maximally 1,493 +/- 250 pmol/L at 45 min, whereas total GLP-2 increased to 2,793 +/- 477 pmol/L at 90 min. At 60 min, plasma contained 69 +/- 1% intact GLP-2. In vitro the t(1/2) values were 8.0 +/- 1.5 h (plasma) and 3.3 +/- 0.3 h (blood). GLP-2-(3-33) was the only degradation product identified by HPLC, and a DPP-IV inhibitor abolished the degradation of GLP-2 in vitro. We conclude that GLP-2 is extensively degraded to GLP-2-(3-33) in humans, presumably by DPP-IV. Nevertheless, 69% remains intact 1 h after GLP-2 injection, supporting the possibility of sc use in patients with intestinal insufficiency.
Bridged Polycyclic Compounds. III. Addition of p-Toluenesulfenyl Chloride to Norbornene, Norbornadiene, Aldrin and 9,10-Dihydro-9,10-ethenoanthracene<sup>1,2</sup> (1957)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBridged Polycyclic Compounds. III. Addition of p-Toluenesulfenyl Chloride to Norbornene, Norbornadiene, Aldrin and 9,10-Dihydro-9,10-ethenoanthracene1,2Stanley J. Cristol, Robert P. Arganbright, Gordon D. Brindell, and Roger M. HeitzCite this: J. Am. Chem. Soc. 1957, 79, 22, 6035–6039Publication Date (Print):November 1, 1957Publication History Published online1 May 2002Published inissue 1 November 1957https://pubs.acs.org/doi/10.1021/ja01579a051https://doi.org/10.1021/ja01579a051research-articleACS PublicationsRequest reuse permissionsArticle Views95Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Thermally desorbable passive sampling device for volatile organic chemicals in ambient air (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThermally desorbable passive sampling device for volatile organic chemicals in ambient airRobert G. Lewis, James D. Mulik, Robert W. Coutant, George W. Wooten, and Carl R. McMillinCite this: Anal. Chem. 1985, 57, 1, 214–219Publication Date (Print):January 1, 1985Publication History Published online1 May 2002Published inissue 1 January 1985https://pubs.acs.org/doi/10.1021/ac00279a050https://doi.org/10.1021/ac00279a050research-articleACS PublicationsRequest reuse permissionsArticle Views177Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Automatic communication refinement for system level design (2003)

This paper presents a methodology and algorithms for automatic communication refinement. The communication refinement task in system-level synthesis transforms abstract data-transfer between components to its actual bus level implementation. The input model of the communication refinement is a set of concurrently executing components, communicating with each other through abstract communication channels. The refined model reflects the actual communication architecture. Choosing a good communication architecture in system level designs requires sufficient exploration through evaluation of various architectures. However, this would not be possible with manually refining the system model for each communication architecture. For one, manual refinement is tedious and error-prone. Secondly, it wastes substantial amount of precious designer time. We solve this problem with automatic model refinement. We also present a set of experimental results to demonstrate how the proposed approach works on a typical system level design.
Polymer electronic materials for sustainable energies (2012)

As electronic devices reduce in size, scale and weight, polymers are becoming more attractive as electronic materials that are lighter weight, easier and lower cost to synthesize, and place less demand on purity. However, device performance is significantly influenced by the ability to properly synthesize polymers and integrate them effectively into devices. Particularly with nanostructured device architectures, conventional liquid phase synthesis and processing face significant limitations due to the presence of the liquid medium. Here, initiated chemical vapor deposition (iCVD) is demonstrated as a viable means for overcoming these barriers, providing a liquid-free approach for the direct synthesis and growth of electronic polymers that yield significantly enhanced performance in energy harvesting and storage devices.
Recent Efforts Towards Graphics Standardization (1978)

This paper traces the development of methodologies for graphics system design, and relates these activities to graphics standardization efforts. It describes early work on graphics system design, and presents some of the problems and issues involved in designing portable graphics systems. Two specific issues--application program structure and modularization--are discussed in detail, showing how they impact graphics package design. The paper concludes with a discussion ef how these methodologies were applied to the design of the GSPC Core Graphics System.
Influence of comonomer incorporation on morphology and thermal and mechanical properties of blends based upon isotactic metallocene-polypropene and random ethene/1-butene copolymers (1999)

Blends of isotactic polypropene (i-PP) with random ethene/1-butene (EB) copolymers containing 10, 24, 48, 58, 62, 82, and 90 wt % 1-butene were prepared in order to examine the influence of the EB molecular architecture on the morphology development as well as on the thermal and mechanical properties. Compatibility between i-PP and EB increased with increasing 1-butene content in EB to afford single-phase blends at a 1-butene content exceeding 82 wt %. The morphology was investigated using AFM and TEM. Improved compatibility accounted for enhanced EB dispersion and interfacial adhesion. Highly flexible as well as stiff blends with improved toughness were obtained. © 1999 John Wiley & Sons, Inc. J Appl Polym Sci 74: 838–848, 1999
Transgenic 6F tomatoes act on the small intestine to prevent systemic inflammation and dyslipidemia caused by Western diet and intestinally derived lysophosphatidic acid (2013)

We recently reported that levels of unsaturated lysophosphatidic acid (LPA) in the small intestine significantly correlated with the extent of aortic atherosclerosis in LDL receptor-null (LDLR⁻/⁻) mice fed a Western diet (WD). Here we demonstrate that WD increases unsaturated (but not saturated) LPA levels in the small intestine of LDLR⁻/⁻ mice and causes changes in small intestine gene expression. Confirmation of microarray analysis by quantitative RT-PCR showed that adding transgenic tomatoes expressing the apoA-I mimetic peptide 6F (Tg6F) to WD prevented many WD-mediated small intestine changes in gene expression. If instead of feeding WD, unsaturated LPA was added to chow and fed to the mice: i) levels of LPA in the small intestine were similar to those induced by feeding WD; ii) gene expression changes in the small intestine mimicked WD-mediated changes; and iii) changes in plasma serum amyloid A, total cholesterol, triglycerides, HDL-cholesterol levels, and the fast-performance liquid chromatography lipoprotein profile mimicked WD-mediated changes. Adding Tg6F (but not control tomatoes) to LPA-supplemented chow prevented the LPA-induced changes. We conclude that: i) WD-mediated systemic inflammation and dyslipidemia may be in part due to WD-induced increases in small intestine LPA levels; and ii) Tg6F reduces WD-mediated systemic inflammation and dyslipidemia by preventing WD-induced increases in LPA levels in the small intestine.
Norepinephrine dipivalylate dose-response in ocular hypertensive subjects. (1981)

Norepinephrine dipivalylate, a prodrug analog of the catecholamine mediator norepinephrine, was given to 12 ocular hypertensive patients. Single instillations of four concentrations, 0.05%, 0.1%, 0.25%, and 0.5%, were administered weekly to one eye only with the fellow eye receiving a placebo. Intraocular pressure, pupil size, ocular signs, subjective symptoms, heart rate, and blood pressure were monitored at 2, 4, 6, 8, and 12 hours following instillation. An intraocular pressure reduction dose response was seen. After a slow (four-hour) onset of activity, the 0.5% concentration produced clinically acceptable (less than 22 mm Hg) tensions at the 6-, 8-, and 12-hour observations which were significantly (p less than 0.05, paired t test) lower than placebo-control eyes. No clinically important side effects were seen.
Microbial entry through caveolae: variations on a theme (2002)

Caveolae and lipid rafts are increasingly being recognized as a significant portal of entry into host cells for a wide variety of pathogenic microorganisms. Entry through this mechanism appears to afford the microbes protection from degradation in lysosomes, though the level to which each microbe actively participates in avoiding lysosomal fusion may vary. Other possible variations in microbial entry through caveolae or lipid rafts may include (i) the destination of trafficking after entry and (ii) how actively the microbe contributes to the caveolae lipid/raft mediated entry. It seems that, though a wide variety of microorganisms are capable of utilizing caveolae/lipid rafts in various stages of their intracellular lifestyle, there can be distinct differences in how each microbe interacts with these structures. By studying these variations, we may learn more about the normal functioning of these cellular microdomains, and perhaps of more immediate importance, how to incorporate the use of these structures into the treatment of both infectious and non-infectious disease.
The parathyroid hormone-related protein receptor is expressed in breast cancer bone metastases and promotes autocrine proliferation in breast carcinoma cells (2003)

Overproduction of parathyroid hormone-related protein (PTHRP) occurs in a high proportion of primary breast cancers (PBC) and is strongly implicated in their metastatic spread to bone. Although the PTHRP-receptor (PTHRP-R) is often coexpressed with PTHRP in PBC, its role in regulating breast cancer cell proliferation and metastases to bone remains unclear. The aims of this study were to determine the expression of the PTHRP-R in breast cancer bone metastases (BM) and to investigate the effects of PTHRP-R overexpression on breast cancer cell proliferation. PTHRP-R expression occurred in 85% (11 out of 13) of BM compared with 58% (39 out of 67) of PBC. Median expression was higher (P<0.05) in BM compared with PBC. PTHRP increased cAMP accumulation and DNA synthesis in MCF-7 cells stably overexpressing the PTHRP-R (MCF-7(WTR)) but not in MCF-7(VEC) control cells. The increase in DNA synthesis was mimicked by the cAMP pathway activator forskolin. The receptor antagonist PTHRP(7-34) reduced DNA synthesis in MCF-7(WTR) cells, but not MCF-7(VEC) cells, indicating that receptor overexpression promotes autocrine PTHRP activity. MCF-7(WTR) cells showed increased mitogenic responsiveness to fetal calf serum and reduced doubling times. PTHRP induced weak activation of ERK1 and ERK2 and potentiated their activation by serum growth factors. Collectively these results show that the PTHRP-R is frequently expressed in breast cancer BM and indicate that receptor overexpression drives proliferation via autocrine signals that are mediated via cAMP and ERK pathways.
DNA monolayer on gold substrates characterized by nanoparticle labeling and scanning force microscopy (2001)

Monolayers of single-stranded DNA on gold substrates were studied by scanning force microscopy. Complementary DNA probes labeled by gold nanoparticles were applied for contrast enhancement. Substrate regions modified with DNA could be visualized in a highly specific manner. The influence of the solution concentration on the surface density of adsorbed nanoparticles could be visualized. Because individual label particles can be easily detected, this labeling technique opens the way for characterization of DNA monolayers with a lateral resolution in the nanometer range.
A Locknut for a Weight Buret (1940)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Locknut for a Weight BuretMartin KilpatrickCite this: Ind. Eng. Chem. Anal. Ed. 1940, 12, 9, 548Publication Date (Print):September 1, 1940Publication History Published online1 May 2002Published inissue 1 September 1940https://pubs.acs.org/doi/10.1021/ac50149a024https://doi.org/10.1021/ac50149a024research-articleACS PublicationsRequest reuse permissionsArticle Views20Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts