gebhart/patrepeval huggingface dataset:
Real-time range acquisition by adaptive structured light (2006)

The goal of this paper is to provide a "self-adaptive" system for real-time range acquisition. Reconstructions are based on a single frame structured light illumination. Instead of using generic, static coding that is supposed to work under all circumstances, system adaptation is proposed. This occurs on-the-fly and renders the system more robust against instant scene variability and creates suitable patterns at startup. A continuous trade-off between speed and quality is made. A weighted combination of different coding cues--based upon pattern color, geometry, and tracking--yields a robust way to solve the correspondence problem. The individual coding cues are automatically adapted within a considered family of patterns. The weights to combine them are based on the average consistency with the result within a small time-window. The integration itself is done by reformulating the problem as a graph cut. Also, the camera-projector configuration is taken into account for generating the projection patterns. The correctness of the range maps is not guaranteed, but an estimation of the uncertainty is provided for each part of the reconstruction. Our prototype is implemented using unmodified consumer hardware only and, therefore, is cheap. Frame rates vary between 10 and 25 fps, dependent on scene complexity.
Neuropeptide Signaling Systems - Potential Drug Targets for Parasite and Pest Control (2002)

Current problems of drug resistance in parasites and pests demand the identification of new targets and their exploitation through novel drug design and development programs. Neuropeptide signaling systems in helminths (nematodes and platyhelminths = worms) and arthropods are well developed and complex, play a crucial role in many aspects of their biology, and appear to have significant potential as targets for novel drugs. The best-known neuropeptide family in invertebrates is the FMRFamide-related peptides (FaRPs). Amongst many roles, FaRPs potently influence motor function. The genome sequencing projects of Drosophila melanogaster and Caenorhabditis elegans have revealed unexpected complexity within the FaRPergic systems of arthropods and nematodes, although available evidence for platyhelminths indicates structural and functional simplicity. Regardless of these differences, FaRPs potently modulate motor function in arthropods, nematodes and platyhelminths and there appears to be at least some commonality in the FaRPergic signaling systems therein. Moreover, there is now increasing evidence of cross-phyla activity for individual FaRPs, providing clear signals of opportunities for target selection and the identification and development of broad-spectrum drugs.
Wireless data harvesting using the AUV Sentry and WHOI optical modem (2015)

The optical communications group at Woods Hole Oceanographic Institution has demonstrated wireless optical transmission of data from a seafloor node to the Sentry AUV. This effort is based on the latest version of the optical modem under continual development at WHOI, and it builds on fieldwork conducted in 2012 and 2013 during which we successfully transferred data from seafloor-deployed optical modem systems using a wire-lowered optical modem from a ship. While our previous work used a high-bandwidth optical modem for the data uplink and an acoustic modem “backlink” to control the file transfer, the optical modem described in this paper supports fully bidirectional optical communication-essentially subsea WiFi. A subordinate objective of our work was to literally map the operational space for an AUV-bottom node optical link. Armed with this spatial map, we can plan for future “connected” AUV operations in support of data mule, inspection, manipulation, and other underwater semi-autonomous tasks.
Structure of the neuroleptic drug 4-amino-N-1-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-methoxybenzamide (amisulpride) (1990)

C17H27N3O4S, Mr = 369.48, monoclinic, P2(1)/c, a = 13.333 (7), b = 7.946 (4), c = 17.550 (10) A, beta = 96.99 (4) degrees, V = 1845 (2) A3, Z = 4, Dm = 1.33, Dx = 1.330 Mg m-3, graphite-monochromated Cu K alpha radiation, lambda = 1.54178 A, mu = 1.744 mm-1, F(000) = 792, T = 293 K. Final R = 0.038 for 2405 unique observed reflections. The folded conformation of the molecule with the least-squares planes of the aromatic and the pyrrolidine rings almost perpendicular is essentially determined by intra- and intermolecular hydrogen bonds. In this way, two pseudorings are formed, one linking the amide H with the methoxy O, and a second one involving the 4-amino H and a sulfonyl O. An intermolecular hydrogen bond forces the planar amide group some 28 degrees out of the plane of the aromatic ring.
Monoclonal Antibodies to Human Prostate Cancer-Related Antigens (1985)

Hybridoma-derived monoclonal antibodies potentially useful in immunodiagnosis and immunotherapy of human prostate cancer is the subject of this chapter. These monoclonal antibodies are directed primarily against protein components of malignant and normal prostate. The protein component or its derivative is thus defined operationally as antigen. As in other human tumors, prostate tumor specific antigen is yet to be identified even with the recently developed somatic cell hybridization technology. Several groups of investigators have produced monoclonal antibodies that recognize prostate cancer-associated antigenic components, or are directed to chemically well-defined organ-site cell-type specific proteins of the prostate, such as prostate specific antigen and prostatic acid phosphatase. At this stage of development, only monoclonal antibodies of murine origin are well described. Production and characterization of these antibodies are the major topic of this review. Experimental application of monoclonal antibodies to prostate antigen and prostatic acid phosphatase as serodiagnostic and immunohistologic reagent for prostate cancer is also described.
Vapochromism and Its Structural Basis in a Luminescent Pt(II) Terpyridine−Nicotinamide Complex (2004)

A novel Pt(II) terpyridine complex that has a nicotinamide moiety linked to the terpyridyl ligand has been synthesized in good yield and studied structurally and spectroscopically. The complex, [Pt(Nttpy)Cl](PF(6))(2) where Nttpy = 4'-(p-nicotinamide-N-methylphenyl)-2,2':6',2' '-terpyridine, is observed to be brightly luminescent in the solid state at room temperature and at 77 K. The complex exhibits reversible vapochromic behavior and crystallographic change in the presence of several volatile organic solvents. Upon exposure to methanol vapors, the complex changes color from red to orange, and a shift to higher energy is observed in the emission maximum with an increase in excited-state lifetime and emission intensity. The crystal and molecular structures of the orange and red forms, determined by single-crystal X-ray diffraction on the same single crystal, were found to be equivalent in the molecular sense and only modestly different in terms of packing. In both forms, the cationic Pt(II) complexes possess distorted square planar geometries. Analysis of the orange form's crystal packing reveals the presence of solvent molecules in lattice voids, Pt...Pt separations averaging 3.75 A and a zigzag arrangement between nearest neighbor Pt atoms, whereas the red form is devoid of solvent within the crystal lattice and contains complexes stacked with a nearly linear arrangement of Pt(II) ions having an average distance of 3.33 A. On the basis of the crystallographic data, it is evident that sorption of methanol vapor induces a change in intermolecular contacts and Pt...Pt interactions in going from red to orange. Disruption of the d(8)-d(8) metallophilic interactions consequently alters the emitting state from (3)[(d)sigma*-pi*(terpyridine)] that is formally a metal-metal-to-ligand charge transfer (MMLCT) state in the red form to one in which the HOMO corresponds to a more localized Pt(d) orbital in the red form ((3)MLCT).
Inhibition of lymphoproliferative responses by SK&F 105685, a novel anti-arthritic agent. (1991)

SK&F 105685 (N,N-Dimethyl-8,8-dipropyl-2-azaspiro[4.5]decane-2-propanamine+ ++ dihydrochloride) is a novel azaspirane with beneficial activity in animal models of autoimmune diseases such as adjuvant-induced arthritis and experimental autoimmune encephalomyelitis in the Lewis rat and lupus-like disease in the MRL mouse. The effect of SK&F 105685 on the proliferation of rat lymphoid cells was examined in vitro. The compound inhibited the proliferative response of spleen, thymus and lymph node cells to the mitogen concanavalin A (Con A) in a dose-dependent manner but had little or no effect on the mitogenic response of peripheral blood lymphocytes. Although less potent than cyclosporin A, SK&F 105685 was able to inhibit the proliferation of spleen cells stimulated with PMA and ionomycin or the mitogens phytohemagglutinin (PHA), Con A and pokeweed mitogen (PWM). Relatively early event(s) in cell proliferation were affected by SK&F 105685 since delaying addition of the drug by 24 to 48 hours after Con A stimulation of rat spleen cells resulted in reduced levels of suppression. The mode of action of SK&F 105685 appeared to differ from that of cyclosporin A or rapamycin. Unlike cyclosporin A, SK&F 105685 did not affect IL-2 production by Con A-stimulated spleen cells or the IL-2-producing Jurkat cell line, but, like rapamycin, the compound significantly reduced the IL-2-induced proliferation of rat ConA blasts. These results suggest that inhibition of lymphocyte proliferation by SK&F 105685 may require the activity of an intermediate effector cell(s) present in susceptible populations such as cells from the spleen, thymus, lymph nodes and Con A blast preparations but absent or present in low numbers in resistant populations such as peripheral blood cells. Indomethacin and NG-monomethyl-L-arginine (NGMMA), a competitive inhibitor of nitric oxide synthase, were both unable to relieve SK&F 105685-induced suppression of splenic Con A responses thereby ruling out a role for the production of prostaglandins or nitric oxide by macrophages as an intermediate in drug-mediated suppression. In summary, SK&F 105685 was unable to inhibit lymphoproliferative responses by a mechanism distinct from that of cyclosporin A or rapamycin and which appears to involve regulation of cellular interactions rather than a direct effect on responding lymphocytes.
Silencing of the <i>Fibroblast growth factor 21</i> gene is an underlying cause of acinar cell injury in mice lacking MIST1 (2014)

Fibroblast growth factor 21 (FGF21) is a key regulator of metabolism under conditions of stress such as starvation, obesity, and hypothermia. Rapid induction of FGF21 is also observed in experimental models of pancreatitis, and FGF21 reduces tissue damage observed in these models, suggesting a nonmetabolic function. Pancreatitis is a debilitating disease with significant morbidity that greatly increases the risk of pancreatic ductal adenocarcinoma. The goals of this study were to examine the regulation and function of FGF21 in acinar cell injury, specifically in a mouse model of pancreatic injury (Mist1(-/-)). Mist1(-/-) mice exhibit acinar cell disorganization, decreased acinar cell communication and exocytosis, and increased sensitivity to cerulein-induced pancreatitis (CIP). Examination of Fgf21 expression in Mist1(-/-) mice by qRT-PCR, Northern blot, and Western blot analyses showed a marked decrease in pancreatic Fgf21 expression before and after induction of CIP compared with C57Bl/6 mice. To determine whether the loss of FGF21 accounted for the Mist1(-/-) phenotypes, we generated Mist1(-/-) mice overexpressing human FGF21 from the ApoE promoter (Mist1(-/-)ApoE-FGF21). Reexpression of FGF21 partially mitigated pancreatic damage in Mist1(-/-) tissue based on reduced intrapancreatic enzyme activation, reduced expression of genes involved in fibrosis, and restored cell-cell junctions. Interestingly, alteration of Fgf21 expression in Mist1(-/-) tissue was not simply due to a loss of direct transcriptional regulation by MIST1. Chromatin immunopreciptation indicated that the loss of Fgf21 in the Mist1(-/-) pancreas is due, in part, to epigenetic silencing. Thus, our studies identify a new role for FGF21 in reducing acinar cell injury and uncover a novel mechanism for regulating Fgf21 gene expression.
Australian online newspapers: a website content analysis approach to measure interactivity (2007)

This paper addresses the growth and development of the concept of interactivity in online newspapers from the perspectives of computer-mediated communication, journalism, advertising, and information system. This paper discusses the concept of interactivity originally coined by Heeter. The study maps Heeter’s dimensions that are content availability and choice, communication opportunity, effort of users, responsiveness, and customization and management of information onto contemporary settings of Australian online newspaper industry. The researchers reviewed 12 Australian online newspapers over two snapshots using website content analysis approach. Results draws out interesting discussions as to the level of interactivity highlighted by the online newspapers industry. Content availability and choice was found to be the most significant element of interactivity. It is noted that, while the majority of Australian online newspapers offer interactive functionality for expressing opinions, blogging, contests and polls, only one online newspaper provided genuine interactive gaming.
Liposomes in drug delivery: a patent review (2007 – present) (2013)

Liposomes have received great attention given their biocompatibility, biodegradability and targetability. From 2007 to present date, patent publications related to their use in drug delivery have shown the move towards more stable structures with optimized drug delivery capabilities, further combining passive and active targeting concepts to gain control of the in vivo fate. However, the introduction of all these liposomal structures in the disease arena is still a challenge. Two key aspects are the difficulty of identifying easy and economic synthesis conditions which can be scaled up in the pharmaceutical industry, and the need for complementary investigations illustrating risks of toxicity/immunogenicity.
Composition of Cold-Pressed Bitter Orange Peel Oil from Turkey (2003)

Abstract The composition of the laboratory-prepared Turkish bitter orange oil (Citrus aurantium L) samples (bitter orange fruits cultivated two different area) were studied. The volatile fraction was analyzed by GC and GC/MS, and 29 components were identified in the oil. The results obtained were compared with those in the literature for Italian and Spanish bitter orange oil. The identified components were grouped into six classes (monoterpene hydrocarbons, sesquiterpenes, oxygenated compounds, carbonyl compounds, alcohols, and esters). Variations in the oil composition relative to the fruit provenance, the percentage of the each component and six classes, were also described. It was found that the oil composition varied according to the fruit provenance. The main components of the oil were limonene (93.68-94.32%), myrcene (1.73-1.86%), linalyl acetate (1.17-1.32%), linalool (0.33-0.46%), (β-pinene (0.40-0.57%) and α-pinene (0.39-0.45%).
Aryloxyacetones<sup>1</sup> (1946)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAryloxyacetones1Charles D. Hurd and Percy PerletzCite this: J. Am. Chem. Soc. 1946, 68, 1, 38–40Publication Date (Print):January 1, 1946Publication History Published online1 May 2002Published inissue 1 January 1946https://pubs.acs.org/doi/10.1021/ja01205a012https://doi.org/10.1021/ja01205a012research-articleACS PublicationsRequest reuse permissionsArticle Views516Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
An Explicit Rate-Optimal Streaming Code for Channels With Burst and Arbitrary Erasures (2019)

In this paper, we consider transmitting a sequence of messages (a streaming source) over a packet erasure channel, where every source message must be recovered perfectly at the destination subject to a fixed decoding delay. Recently, the capacity of such a channel was established. However, the codes shown to achieve the capacity are either non-explicit constructions (proven to exist) or explicit constructions requiring large field size that scales exponentially with the delay. This work presents an explicit rate-optimal construction for all channel and delay parameters over a field size that scales only quadratically with the delay.
Efficient shared memory for testing parallel algorithms on distributed systems (2003)

A distributed data structure called a MOOSE (modifiable object structure), which is both efficient enough and general enough to be used by a wide variety of parallel algorithms, is outlined. The MOOSE structure is aimed at a loosely coupled distributed system in which several processors are connected over a local area network. It is implemented in the high-level distributed programming language SR on several Sun-2 and Sun-3 workstations running the Unix operating system and connected by an Ethernet. The MOOSE shared memory has been designed with customizable features for efficiency of implementation in such an environment. This enables the communication and computation performance of parallel algorithms on non-shared-memory hardware to be studied. If the application is run in the background on several network nodes, automatic load balancing is achieved and the programs may be tolerant of node failure during the computation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
DISCUSSION. THE ELECTRIFICATION OF THE WIRRAL LINES OF THE LONDON, MIDLAND AND SCOTTISH RAILWAY. RAILWAY ENGINEERING DIVISION. (1944)

Keywords THE LONDON, MIDLAND AND SCOTTISH RAILWAY, LONDON PASSENGER TRANSPORT BOARD ELECTRIFICATION, LINES, RAILWAYS, ENERGY, TRACK, EQUIPMENT, MAINTENANCE, DESIGN, CONSUMPTION, SAVING, DEFECTS, MEASUREMENT, HIGH, TENSION, ROLLING STOCK WIRRAL, LONDON, MIDLAND, SCOTLAND, TYNESIDE UK... Show All
Big Advantages in Membrane Filtration (1999)

Many small water systems are coping with an aging or nonexistent treatment facility, regulatory agencies requiring immediate action, and limited funding for drinking water projects. Solutions are often difficult to implement because of economic situations, staffing considerations, and other issues specific to small water systems. To provide safe drinking water to their customers while dealing with these challenges, many small water systems are turning to membrane filtration.
Galactosyl receptor, a cell surface C-type lectin of normal and tumoral prostate epithelial cells with binding affinity to endothelial cells (2000)

BACKGROUND The mechanism of bone metastasis of prostate cancer involves the interaction of cell surface receptor(s) on cancer cells with ligand(s) on bone marrow endothelial cell surfaces. The rat galactosyl receptor gene generates two mRNA species by differential splicing: one species encodes a protein identical to the minor form of hepatocyte asialoglycoprotein receptor and displays a galactose/N-acetyl-galactosamine-recognition domain; the other encodes a protein with identical intracellular and transmembrane domains but with a different extracellular domain lacking the carbohydrate-recognition domain (CRD). Both proteins appear to coexist as a heterooligomer on the surface of normal mouse, rat, and human prostate epithelial cells and human prostate cancer cells, including the PC-3 cell line. The CRD of galactosyl receptor mediates adhesion of normal and tumoral prostate cells to the surfaces of a human bone marrow endothelial cell line. The use of inhibitors targeting the CRD would be very valuable in hindering the binding of prostate cancer cells to endothelial cells, thus decreasing the incidence of hematogenous metastasis to bone. METHODS Molecular biology, immunohistochemistry, flow cytometry, and a cell aggregation assay were used to determine the expression and role of the galactosyl receptor in cell adhesion. RESULTS Immunoblotting experiments demonstrated that each component of the heterooligomer has a mass of 54 kDa, ascribed in part to associated carbohydrates. An oligonucleotide probe showed the presence of both galactosyl receptor forms in rat prostate and testis, but not in liver, kidney, and spleen. Antibodies to the CRD and a segment of the nonhomologous extracellular domain of the galactosyl receptor blocked cell adhesion to endothelial cell monolayers. CONCLUSIONS The galactosyl receptor provides a valuable target for the development and use of synthetic ligands capable of disrupting endothelial cell-prostate cancer cell interaction, the first step in prostate cancer bone metastasis. Prostate 43:175–183, 2000. © 2000 Wiley-Liss, Inc.
Effect of Hole Exit Shaping on Film Cooling Performance for Tripod Hole Injection Over a Flat Surface (2013)

The effect of hole exit shaping on both heat transfer coefficient and film cooling effectiveness of tripod injection holes is examined experimentally on a flat plate. Previously, it has been clearly proven that tripod hole configurations provide at least 50–60% more cooling effectiveness while using 50% less coolant than standard cylindrical and shaped hole exit geometries. Temperature data is collected using infrared thermography at different operating conditions to determine the benefit of shaping the hole exits for an already proven tripod hole configuration. The test rig consists of a rectangular test section with a main stream flow at 7.9 m/s and coolant flow injected through the bottom surface through the film cooling injection holes. A unique transient IR technique has been used to determine both the adiabatic film effectiveness and heat transfer coefficient from a single test. Two different exit shaping have been considered, one with a 5° flare and layback and one with a 10° flare and layback. Results show that exit shaping improves the performance of these tripod holes compared to the cylindrical hole exits. The 10° flare and layback exit performs slightly better than the 5° flare and layback exit.
Symbolic functional and timing verification of transistor-level circuits (1999)

We introduce a new method of verifying the timing of custom CMOS circuits. Due to the exponential number of patterns required, traditional simulation methods are unable to exhaustively verify a medium-sized modern logic block. Static analysis can handle much larger circuits but is not robust with respect to variations from standard circuit structures. Our approach applies symbolic simulation to analyze a circuit over all input combinations without these limitations. We present a prototype simulator (SirSim) and experimental results. We also discuss using SirSim to verify an industrial design which previously required a special-purpose verification methodology.