gebhart/patrepeval huggingface dataset:
Synthesis and Properties of Oligonucleotides Carrying Cryptolepine Derivatives (2004)

A carboxy derivative of the antimalarial cytotoxic drug cryptolepine was introduced into synthetic oligonucleotides by reaction of the carboxy derivative of cryptolepine with oligonucleotides carrying an amino group either at the 3'- or at the 5'-end. Oligonucleotides carrying the cryptolepine derivative bind their complementary sequences with greater affinity than unmodified ones. When cryptolepine is attached to a polypyrimidine oligonucleotide designed to form a parallel triplex, the triplex shows none or weak stabilization.
Generation of high-power femtosecond pulses near 1.5 mu m using a color-center laser system (1992)

The authors have developed a high-power F-center laser system capable of generating femtosecond pulses with energies exceeding 50 pJ at wavelengths near 1.5 mu m. Short pulses (140 fs) from an additive-pulse mode-locked NaCl laser are amplified in a multipass NaCl amplifier at kilohertz repetition rates. The system can generate peak powers approaching 500 MW, with wavelengths tunable from 1.52 to 1.64 mu m. The amplified pulses are used to generate a continuum in various solid media without optical damage. The continuum generated in BaF/sub 2/ is extremely broad, extending from below 400 nm to 3.5 mu m. Construction and operating details are discussed as well as the system's utility for femtosecond measurements in the infrared and high-power experiments.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Enhanced liquid atomization: From flow-focusing to flow-blurring (2005)

This letter describes the generation of small turbulence scales in connection with a singular back-flow pattern leading to efficient atomization. A simple pneumatic atomizer configuration results, with a tenfold efficiency increase over available plain-jet air-blast atomizers. Back-flow atomization derives from a global bifurcation of the liquid-gas flow pattern; the bifurcation is triggered by a single geometrical parameter of the atomizer. The extremely simple geometry involved can be implemented down to the micrometric scale, thus opening the door to the improvement of current atomizers and to unprecedented designs.
Intramolecular Asymmetric Cyclopropanation with (Nitroso)(salen)ruthenium(II) Complexes as Catalysts (2001)

Intramolecular cyclopropanation of (E)-2-alkenyl-α-diazoacetates was carried out with good to high enantioselectivity by using (nitroso)(salen)ruthenium(II) complexes as catalysts under photo-irradiation.
Protect your BSN: No Handshakes, just Namaste! (2013)

Privacy of physiological data collected by a network of embedded sensors on human body is an important issue to be considered. Physiological signal-based security is a light weight solution which eliminates the need for security key storage and complex exponentiation computation in sensors. An important concern is whether such security measures are vulnerable to attacks, where the attacker is in close proximity to the BSN and senses physiological signals through processes such as electromagnetic coupling. Recent studies show that when two individuals are in close proximity, the electrocardiogram of one person gets coupled to the electroencephalogram of the other, thus indicating a possibility of proximity-based security attacks. This paper proposes a model-driven approach to proximity-based attack on security using physiological signals and evaluates its feasibility. Results show that a proximity-based attack can be successful even without the exact reconstruction of the physiological data sensed by the attacked BSN.
Modular Verification of Interrupt-Driven Software (2017)

Interrupts have been widely used in safety-critical computer systems to handle outside stimuli and interact with the hardware, but reasoning about interrupt-driven software remains a difficult task. Although a number of static verification techniques have been proposed for interrupt-driven software, they often rely on constructing a monolithic verification model. Furthermore, they do not precisely capture the complete execution semantics of interrupts such as nested invocations of interrupt handlers. To overcome these limitations, we propose an abstract interpretation framework for static verification of interrupt-driven software that first analyzes each interrupt handler in isolation as if it were a sequential program, and then propagates the result to other interrupt handlers. This iterative process continues until results from all interrupt handlers reach a fixed point. Since our method never constructs the global model, it avoids the up-front blowup in model construction that hampers existing, non-modular, verification techniques. We have evaluated our method on 35 interrupt-driven applications with a total of 22,541 lines of code. Our results show the method is able to quickly and more accurately analyze the behavior of interrupts.
Algunos supuestos controvertidos en la motivación de resoluciones judiciales (2011)

La controversia generada en sede doctrinal y jurisprudencial sobre el alcance y la extension de la motivacion judicial, ha planteado la contraposicion entre los conceptos de motivacion completa y motivacion suficiente, que en nuestra opinion resulta ineficaz para resolver el debate sobre el alcance y extension de la motivacion, siendo mas preferible tomar en consideracion la idea de motivacion correcta o aceptable como elemento para la superacion efectiva de dicha contraposicion conceptual de resultados inciertos, y conocimiento efectivo de cual ha de ser la motivacion juridicamente exigible en cada caso concreto; concepto particularmente util en diversos supuestos controvertidos como el caso de la motivacion implicita, la motivacion per relationem, la motivacion por formularios, la motivacion reforzada y la motivacion sucinta o concisa.
LinkedIn skills (2014)

"Skills and Expertise" is a data-driven feature on LinkedIn, the world's largest professional online social network, which allows members to tag themselves with topics representing their areas of expertise. In this work, we present our experiences developing this large-scale topic extraction pipeline, which includes constructing a folksonomy of skills and expertise and implementing an inference and recommender system for skills. We also discuss a consequent set of applications, such as Endorsements, which allows members to tag themselves with topics representing their areas of expertise and for their connections to provide social proof, via an "endorse" action, of that member's competence in that topic.
The Relationship of Cell and Organism in Vascular Plants (1991)

Journal Article The Relationship of Cell and Organism in Vascular Plants: Are cells the building blocks of plant form? Get access Donald R. Kaplan, Donald R. Kaplan Search for other works by this author on: Oxford Academic Google Scholar Wolfgang Hagemann Wolfgang Hagemann Search for other works by this author on: Oxford Academic Google Scholar BioScience, Volume 41, Issue 10, November 1991, Pages 693–703, https://doi.org/10.2307/1311764 Published: 01 November 1991
Convergent total synthesis of lamellarin K† (1997)

The azomethine ylide derived from dihydroisoquinolinium salt 24 undergoes an intramolecular [3 + 2] cycloaddition reaction to give pyrrole 25 which upon de-isopropylation affords the marine alkaloid lamellarin K 4.
Design, modeling, and prototyping of microinterferometric tomography system for optical fiber inspection (2006)

In this paper we present the novel concept of tomography system for characterization of small phase microelements such as telecom fiber splices. We demonstrate the measurement method, existing setup and its modification towards creation of miniaturized waveguide based Mach-Zehnder interferometer for telecom fiber assessment. Additionally we present and analyze Deep Proton Writing as a promising technology for rapid prototyping of monolithic microinterferometer in PMMA.
Comparison of Writing Performance in a Field-Specific and a Regular Essay Test (2005)

A field-specific essay test was developed as an attempt to improve the ESL placement procedure for international graduate students at the University of Illinois at Urbana-Champaign (UIUC). Graduate departments were classified into four areas, business, humanities/social sciences, technology and life sciences, and a set of four input prompts, and writing questions was developed. A total of 124 volunteers participated in taking both the regularly-required general-topic test and the field-specific test. A total-group FACETS analysis of the students’ performance on the two tests showed that they performed better on the field-specific test. However, subgroup analyses showed the field-specific topic effect only in the business and life sciences subgroups, while no prompt effect was found for the humanities/social sciences and technology subgroups. Considering that early in the test development procedure, these results were predicted by in a prompt evaluation session, the results suggest that more effort should be exerted to carefully select the topic and content of prompts in order to secure equivalency of the topic effect across all disciplinary groups. This paper further addresses limitations and promising research directions.
The Value of Thoracic Computed Tomography Scans in Clinical Diagnosis: A Prospective Study (2006)

The CT scan results were associated with a change in diagnosis in 48% of cases. Normal scans constituted 25% of the total and had the greatest impact scores. Waiting times were highly correlated with increased urgency of the presenting problem.
Fabrication of micro-optics by microjet printing (1995)

Microjet printing methods are being utilized for data-drive fabrication of micro-optical elements such as refractive lenslet arrays, multimode waveguides and microlenses deposited onto the tips of optical fibers. Materials used for microjet printing of micro-optics to date have included optical adhesives and index-tuned thermoplastic formulations dispensed at temperatures up to 200 degree(s)C onto optical substrates and components. By varying such process parameters as numbers and locations of deposited microdroplets, print head temperature and orifice size, and target substrate temperature and surface wetability, arrays of spherical and cylindrical plano-convex microlenses have been fabricated with dimensions ranging from 80 micrometers to 1 mm to precision levels of just a few microns, along with multimode channel waveguides. Optical performance data such as lenslet f/#s and far-field diffraction patterns are presented, along with beam-steering agility data obtained with an optical telescope system assembled from microlens arrays printed by this process.
The DLT priority sampling is essentially optimal (2006)

The priority sampling procedure of N. Duffield, C. Lund and M. Thorup is not only an exciting new approach to sampling weighted data streams, but it has also proven to be highly successful in a variety of practical applications. We resolve the two major issues related to its performance. First we solve the main conjecture of N. Alon, N. Duffield, C. Lund and M. Thorup in [1], which states that the standard deviation for the subset sum estimator obtained from k priority samples is upper bounded by W/√k-1, where W denotes the actual subset sum that the estimator estimates. Although Alon et al. give an O(W/√k-1) upper bound on the standard deviation of the estimator, their formula cannot be used as a performance guarantee in an applied setting, because the constants coming up in their proof are very large. Our constant cannot be improved. We also resolve the conjecture of Duffield, C. Lund and M. Thorup which states that the variance of the priority sampling procedure is not larger than the variance of the threshold sampling procedure with sample size only one smaller. This is the main conjecture in [7]. The conjecture's significance is that the latter procedure is provably optimal within a very general class of sampling algorithms, but unlike priority sampling, it is not practical. Our result therefore certifies that priority sampling offers the unlikely feat of uniting mathematical elegance, (essential) optimality and applicability. Our proof is based on a new integral formula and on very finely tuned telescopic sums.
Use of Image Processing Techniques to Automatically Diagnose Sickle-Cell Anemia Present in Red Blood Cells Smear (2013)

Fluorescence titrations and temperature-jump relaxation experiments were performed as a function of temperature on ribonuclease T1 with the inhibitors 2'GMP and 3'GMP to obtain information on the energetics and molecular events controlling the binding of those inhibitors. Results from the titration and temperature-jump experiments were in agreement concerning the equilibrium constant. The larger equilibrium constant for 2'GMP is enthalpic in origin and is due to both a higher on rate and a lower off rate as compared to 3'GMP. On rates for both inhibitors appear to be below the diffusion controlled limit, apparently due to conformational changes in the portion of the active site responsible for recognition of the guanine base. Comparison of the measured enthalpic and entropic terms associated with the equilibrium constant determined from the fluorescence titrations are in disagreement with those calculated from the on and off rates indicating the presence of an induced conformational change in the 2'GMP-enzyme complex. This second conformational change appears to be due to additional interactions between 2'GMP and the catalytic portion of the active site, which may also be responsible for the differences in the binding constant, the on rate and the off rate between 2'GMP and 3'GMP.
Influence of Cultivation Media on Genetic Regulatory Patterns in <i>Borrelia burgdorferi</i> (2001)

Barbour-Stoenner-Kelly II (BSKII) medium and BSKH medium both are routinely used for the cultivation of Borrelia burgdorferi. However, heretofore there have been no studies to compare how these two media affect gene expression patterns in virulent B. burgdorferi. In the present study, we found that some B. burgdorferi strain 297 genes (e.g., ospA, mlp-7A, mlp-8, p22, and lp6.6) that typically are regulated by temperature or pH displayed their predicted pattern of expression when B. burgdorferi was cultivated in BSKH medium; this was not true when spirochetes were cultivated in conventional BSKII medium. The results suggest that BSKH medium is superior to BSKII medium for gene expression studies with B. burgdorferi.
Good and bad dynamic polling orders in symmetric single buffer Markovian multiserver multiqueue systems (2002)

Generalized stochastic Petri nets (GSPNs) are used to study the performances of several dynamic polling orders in symmetric multiserver multiqueue systems with one-buffer queues and Markovian interarrival, service, and walk times. Exact numerical results are obtained by means of Great-SPN, a software tool for the analysis of GSPNs, and are presented as curves of the average customer delay and waiting time. The results quantify the performance differences among the various polling orders, and show that the usual cyclic order can be the most effective, if the possibility of shorter walk times in the cyclic cases is adequately taken into account.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Genomics and taxonomy in diagnostics for food security: soft-rotting enterobacterial plant pathogens (2015)

Whole genome comparisons provide a quantitative, objective basis for taxonomic classification of bacterial pathogens important to food security.
Nonchaotic Transition from Quasiperiodicity to Complete Phase Locking (1988)

We show the existence of a generic integrate-and-fire phenomenon which separates the transition to complete phase locking from the transition to chaos. We argue that our picture provides a natural explanation of "missing" hysteretic bands in the Belousov-Zhabotinskii reaction. In addition, we explain the origin of experimentally observed "deviations from universality" and bumps in the Arnold tongues in driven relaxation oscillators.
Indoor Patient Position Estimation Using Particle Filtering and Wireless Body Area Networks (2007)

Wireless Body Area Network (WBAN) has been recently promoted to monitor the physiological parameters of patient in an unobtrusive and natural way. This paper towards to make advantage of those ongoing wireless communication links between the body sensors to provide estimated position information of patients or particular body area networks, which make daily activity surveillance possible for further analysis. The proposed particle filtering based localization algorithm just picks up the received radio signal strength information from beacons or its neighbors to infer its own pose, which do not require additional hardware or instruments. Theoretical analysis and simulation experiments are presented to examine the performance of location estimating method.
Effect of recombinant human granulocyte colony-stimulating factor treatment of mice on spleen colony-forming unit number and self-renewal capacity. (1993)

The aim of this investigation was to find out whether the self-renewal capacity of spleen colony-forming units (CFU-S) changed after treatment of CBF1 (CBA-LacxC57B1/6) F1 female mice with granulocyte colony-stimulating factor (G-CSF). In addition, the possibility of synergism between erythropoietin (Epo) and G-CSF in blood stem cell mobilization was studied. Twenty-five and 250 micrograms/kg/d injections of recombinant human (rh) G-CSF expanded the number of CFU-S in peripheral blood four- and 32-fold. The self-maintenance potential of CFU-S did not change significantly. The treatment of mice with 250 micrograms/kg/d rhG-CSF resulted in a two-fold increase of spleen cellularity and a 15-fold augmentation of CFU-S number, without noticeable changes in their self-renewal capacity. Moderate changes in CFU-S number were observed after Epo administration in spleen and peripheral blood; however, no significant synergistic effect of Epo was detected with either dose of rhG-CSF. The multifold increase of CFU-S number in peripheral blood following rhG-CSF administration, with no reduction in their generating potential, suggests that rhG-CSF-mobilized blood stem cells provide an appropriate source for reconstitution of the hematopoietic system.
Mitochondria‐Penetrating Peptides: Sequence Effects and Model Cargo Transport (2009)

A class of mitochondria-penetrating peptides (MPPs) was studied in an effort to optimize their applications in the delivery of bioactive cargo to this therapeutically important organelle. The sequence requirements for mitochondrial entry were monitored, and it was discovered that while an alternating cationic/hydrophobic residue motif is not required, the inclusion of a stretch of adjacent cationic amino acids can impede access to the organelle. In addition, a variety of N- and C-terminal cargo were tested to determine if there are limitations to the lipophilicity, charge, or polarity of compounds that can be transported to mitochondria by MPPs. The results reported demonstrate that these peptide sequences are versatile transporters that will have a range of biological applications.
Modified gel electrophoresis for higer resolution of DNA fingerprints (1988)

Journal Article Modified gel electrophoresis for higer resolution of DNA fingerprints Get access Esther Signer, Esther Signer Institute for Animal Breeding Techniques, Department for Laboratory Animals, University of Zürich-IrchelWinterthurerstr, 190 CH-8057 Zü, Switzerland Search for other works by this author on: Oxford Academic PubMed Google Scholar Clive C. Kuenzle, Clive C. Kuenzle 1Institute of Pharmacology and Biochemistry, University of Zürich-IrchelWinterthurerstr, 190 CH-8057 Zü, Switzerland Search for other works by this author on: Oxford Academic PubMed Google Scholar Peter E. Thomann, Peter E. Thomann Institute for Animal Breeding Techniques, Department for Laboratory Animals, University of Zürich-IrchelWinterthurerstr, 190 CH-8057 Zü, Switzerland Search for other works by this author on: Oxford Academic PubMed Google Scholar Ulrich Hübscher Ulrich Hübscher 1Institute of Pharmacology and Biochemistry, University of Zürich-IrchelWinterthurerstr, 190 CH-8057 Zü, Switzerland Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 16, Issue 15, 11 August 1988, Page 7739, https://doi.org/10.1093/nar/16.15.7739 Published: 11 August 1988 Article history Accepted: 21 June 1988 Published: 11 August 1988
Investigation of time-resolved proton radiography using x-ray flat-panel imaging system (2017)

Proton beam therapy benefits from the Bragg peak and delivers highly conformal dose distributions. However, the location of the end-of-range is subject to uncertainties related to the accuracy of the relative proton stopping power estimates and thereby the water-equivalent path length (WEPL) along the beam. To remedy the range uncertainty, an in vivo measurement of the WEPL through the patient, i.e. a proton-range radiograph, is highly desirable. Towards that goal, we have explored a novel method of proton radiography based on the time-resolved dose measured by a flat panel imager (FPI). A 226 MeV pencil beam and a custom-designed range modulator wheel (MW) were used to create a time-varying broad beam. The proton imaging technique used exploits this time dependency by looking at the dose rate at the imager as a function of time. This dose rate function (DRF) has a unique time-varying dose pattern at each depth of penetration. A relatively slow rotation of the MW (0.2 revolutions per second) and a fast image acquisition (30 frames per second, ~33 ms sampling) provided a sufficient temporal resolution for each DRF. Along with the high output of the CsI:Tl scintillator, imaging with pixel binning (2 × 2) generated high signal-to-noise data at a very low radiation dose (~0.1 cGy). Proton radiographs of a head phantom and a Gammex CT calibration phantom were taken with various configurations. The results of the phantom measurements show that the FPI can generate low noise and high spatial resolution proton radiographs. The WEPL values of the CT tissue surrogate inserts show that the measured relative stopping powers are accurate to ~2%. The panel did not show any noticeable radiation damage after the accumulative dose of approximately 3831 cGy. In summary, we have successfully demonstrated a highly practical method of generating proton radiography using an x-ray flat panel imager.
Pharmacologic Inhibition of Squalene Synthase and Other Downstream Enzymes of the Cholesterol Synthesis Pathway (2009)

Hypercholesterolemia is a major risk factor for the development of atherosclerotic vascular diseases. The most popular agents for cholesterol reduction are the statin drugs, which are competitive inhibitors of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the primary rate-limiting enzyme in the hepatic biosynthesis of cholesterol. Although relatively safe and effective, the available statins can cause elevations in liver enzymes and myopathy. Squalene synthase is another enzyme that is downstream to HMG-CoA reductase in the cholesterol synthesis pathway and modulates the first committed step of hepatic cholesterol biosynthesis at the final branch point of the cholesterol biosynthetic pathway. Squalene epoxidase and oxidosqualene cyclase are other enzymes that act distally to squalene synthase. Pharmacologic inhibitors of these downstream enzymes have been developed, which may reduce low-density lipoprotein cholesterol and reduce the myopathy side effect seen with upstream inhibition of HMG-CoA. At this juncture, one squalene synthase inhibitor, lapaquistat (TAK-475) is in active clinical trials as a monotherapy, but there have been suggestions of increased hepatotoxicity with the drug.