gebhart/patrepeval huggingface dataset:
Protein-tyrosine Kinase 6 Promotes Peripheral Adhesion Complex Formation and Cell Migration by Phosphorylating p130 CRK-associated Substrate (2011)

Protein-tyrosine kinase 6 (PTK6) is a non-myristoylated intracellular tyrosine kinase evolutionarily related to Src kinases. Aberrant PTK6 expression and intracellular localization have been detected in human prostate tumors. In the PC3 prostate cancer cell line, the pool of endogenous activated PTK6, which is phosphorylated on tyrosine residue 342, is localized at the membrane. Expression of ectopic membrane-targeted PTK6 led to dramatic morphology changes and formation of peripheral adhesion complexes in PC3 cells. Peripheral adhesion complex formation was dependent upon PTK6 kinase activity. We demonstrated that p130 CRK-associated substrate (p130CAS) is a novel direct substrate of PTK6, and it works as a crucial adapter protein in inducing peripheral adhesion complexes. Activation of ERK5 downstream of p130CAS was indispensable for this process. Knockdown of endogenous PTK6 led to reduced cell migration and p130CAS phosphorylation, whereas knockdown of p130CAS attenuated oncogenic signaling induced by membrane-targeted PTK6, including ERK5 and AKT activation. Expression of membrane-targeted PTK6 promoted cell migration, which could be impaired by knockdown of p130CAS or ERK5. Our study reveals a novel function for PTK6 at the plasma membrane and suggests that the PTK6-p130CAS-ERK5 signaling cascade plays an important role in cancer cell migration and invasion.
Portfolio Concentration and the Geometry of Co-Movement (2013)

Understanding correlations and how they change over time is an important aspect of investing. But large correlation matrices are difficult or impossible to grasp intuitively. This article describes a method for transforming a correlation matrix into a point cloud in space, in which two points are close if the corresponding assets are highly correlated, and vice versa. Latent structures in the correlation matrix can thus be visualized geometrically. The method also provides an intuitive way to visualize how the correlation matrix changes over time, and can be used to derive quantitative measures of portfolio concentration. <b>TOPICS:</b>Portfolio construction, in portfolio management, equity portfolio management
Serum Enzyme Profiles Differentiate Five Types of Muscular Dystrophy (2015)

Our approach enabled the determination of MD subtypes using serum enzyme profiles prior to genetic testing, which will increase the chance a mutation will be found in the first gene analyzed.
A hierarchical intelligent control system for milling machine (2002)

A new intelligent adaptive CNC system designed for a milling machine is presented. It is the first time a neural network controller has been applied successfully in the milling process. The direct neural network controller can obtain a constant milling force under varying milling conditions and adjusts its weights on-line without a specific pretraining stage or plant modeling. For improving the system's intelligence level and its practicability, an expert controller is added so that the control system has a hierarchical structure. The milling experimental results show that the system has better control characteristics and can raise machining efficiency and tool protection.
Efficient Encoding And Reconstruction Of Regions Of Interest In Jpeg2000 (2000)

Publication in the conference proceedings of EUSIPCO, Tampere, Finland, 2000
Decrease of Fertilizing Ability of Mouse Spermatozoa after Freezing and Thawing Is Related to Cellular Injury1 (2004)

In general, the fertilizing ability of cryopreserved mouse spermatozoa is less than that of fresh spermatozoa. This ability is especially low in C57BL/6, the main strain used for the production of transgenic mice. To solve this problem, the relationship between cell damage and fertilizing ability in cryopreserved mouse spermatozoa was examined in this study. Sperm motility analysis revealed no significant difference among the motilities of cryopreserved C57BL/6J, BALB/cA, and DBA/2N sperm (67.6%, 43.4%, and 60.0%, respectively) after thawing. However, the results of in vitro fertilization (IVF), scanning electron microscopy (SEM), and transmission electron microscopy (TEM) showed a strong correlation between the frequency of aberrant spermatozoa (FAS) and fertilization rates (FR; C57BL/6J: FAS, 83.7%; FR, 17.0%; BALB/cA: FAS, 67.2%; FR, 24.2%; and DBA/2N: FAS, 10.2%; FR, 93.6%), and damage to spermatozoa was localized particularly in the acrosome of the head and mitochondria.
Real‐time text tracking in natural scenes (2014)

The authors present a system that automatically detects, recognises and tracks text in natural scenes in real‐time. The focus of the author's method is on large text found in outdoor environments, such as shop signs, street names, billboards and so on. Built on top of their previously developed techniques for scene text detection and orientation estimation, the main contribution of this work is to present a complete end‐to‐end scene text reading system based on text tracking. They propose to use a set of unscented Kalman filters to maintain each text region's identity and to continuously track the homography transformation of the text into a fronto‐parallel view, thereby being resilient to erratic camera motion and wide baseline changes in orientation. The system is designed for continuous, unsupervised operation in a handheld or wearable system over long periods of time. It is completely automatic and features quick failure recovery and interactive text reading. It is also highly parallelised to maximise usage of available processing power and achieve real‐time operation. They demonstrate the performance of the system on sequences recorded in outdoor scenarios.
The cost of graft failure and other severe complications after liver transplantation - experience from a German Transplant Center. (2011)

Cost and reimbursement of OLT are relatively moderate in Germany. Graft failure was identified as the major cost-determining factor. The cost impact of post-transplant complications is mainly caused by the length of stay.
Creep Damage Evaluation of Steam Turbine Rotor Steel by Using the Nonlinear Ultrasonic Technique (2016)

摘要： 超超临界汽轮机高温部件长期服役会产生蠕变损伤，威胁设备的强度安全，快速、有效地检出高温构件蠕变损伤状况对保证设备服役安全意义重大。采用中断蠕变试验，在实验室模拟获得了汽轮机转子钢FB2不同程度的蠕变损伤，进 行损伤后试样的非线性超声纵波表征试验。结果表明：非线性超声参量随转子钢FB2蠕变损伤程度的增加而增大；透射电镜微观分析表明，超声非线性参量增大与位错密度增加有关；非线性超声纵波参量与高应力水平下的位错攀移和低应力水平下的位错滑移存在较好的函数关系。进一步以位错密度为中间量，建立非线性参量 和稳态蠕变变形速率 的关联式。
Ferro/antiferromagnetism mediated by interlayer organic spacers in layered copper(II) compounds (1996)

Spectacular and unexpected behaviours from long-range antiferromagnetic to ferromagnetic states are observed for a novel family of layered compounds, Cu2(OH)3X·mH2O (X =n-alkylcarboxylate) depending on the layer spacing (up to ca. 28 Å); in contrast, the analogous n-alkylsulfate derivatives are predominantly three-dimensional antiferromagnets.
Governance in Higher Education: A Comparative Study on Ghana and China (2018)

Governance in higher education is one key concern for policy makers on restructuring the higher educational systems all over the world. The concepts of higher education governance often bring conflict between institutions and politicians on issues concerning institutional management. This study examined the concepts of higher education governance based on a comparative study of china and Ghana. The study gave special attention to various reforms on governance, higher education autonomy, funding, higher education law and structure of decision making in both countries. This paper argued that, if government limits its influence on higher education governance and higher education institutions are given a significant level of autonomy to make decision on academic program development and appointment of key positions, it will enable the higher education leaders use their expertise to develop high quality higher education. However, it’s worth mentioning that, this paper does not argue for governmental absence on higher education governance and management; government will continue with policy formulation on higher education. The comparative study is adopted because, china’s higher education has attracted many students from developing countries in Africa and Asia and Ghana as an African country has over ten thousand students pursuing programs at all levels. Higher institutions in Ghana in the past decade have enjoyed good academic relationship with Chinese institutions. Ghana as a middle-income country in the quest to build high quality higher education can learn from the Chinese system. This study will also contribute to literatures in educational governance. Keywords : higher education, governance, autonomy, reforms.
Evidence for p53-Mediated Modulation of Neuronal Viability (1996)

A role for p53-related modulation of neuronal viability has been suggested by the finding that p53 expression is increased in damaged neurons in models of ischemia and epilepsy. These findings were recently extended with the demonstration that mice deficient in p53 ("knock-out" mice) exhibit almost complete protection from seizure-induced brain injury, whereas wild-type mice display significant neuronal cell loss in the hippocampus and other brain regions. Because the p53 knock-out mice used in the latter study expressed a global p53 deficiency in all cell types, it was not possible to conclude that protection was conferred by the exclusive absence of p53 in neurons. Therefore, in the present study, we determined whether p53 expression in isolated neurons is directly coupled to a loss of viability associated with excitotoxic challenge. Primary cultures of hippocampal or cortical neurons were derived from animals containing p53 (+/+, +/-) or those deficient in p53 (-/-). p53-Deficient neurons appeared identical to wild-type neurons with respect to morphology, neurofilament expression, and resting levels of intracellular calcium. Neurons containing at least one copy of p53 were severely damaged by exposure to kainic acid or glutamate. Cell damage was assessed by direct cell counting and by nuclear morphology after propidium iodide staining of DNA. In contrast, neurons deficient in p53 (-/-) exhibited little or no damage in response to excitotoxin treatment. Despite their divergent outcomes, p53 (+/+) and p53 (-/-) neurons demonstrated similar sustained elevations in intracellular calcium levels triggered by glutamate exposure. Restoring p53 expression to p53-deficient neurons, using adenovirus-mediated transduction, was sufficient to promote neuronal cell death even in the absence of excitotoxin. These results demonstrate a direct relationship between p53 expression and loss of viability in CNS neurons.
Embrittling Components in Sintered Steels: Comparison of Phosphorus and Boron (2017)

Abstract In ferrous powder metallurgy, both boron and phosphorus have been known to be sintering activators for a long time. However, the use has been widely different: while P is a standard additive to sintered iron and steels, boron has been frequently studied, but its use in practice is very limited. Both additives are also known to be potentially embrittling, though in a different way. In the present study the differences between the effects of both elements are shown: while P activates sintering up to a certain threshold, in part by stabilizing ferrite, in part by forming a transient liquid phase, boron is the classical additive enhancing persistent liquid phase, being virtually insoluble in the iron matrix. The consequence is that sintered steels can tolerate quite a proportion of phosphorus, depending on composition and sintering process; boron however is strongly embrittling in particular in combination with carbon, which requires establishing a precisely defined content that enhances sintering but is not yet embrittling. The fracture mode of embrittled materials is also different: while with Fe-P the classical intergranular fracture is observed, with boron a much more rugged fracture surface appears, indicating some failure through the eutectic interparticle network but mostly transgranular cleavage. If carbon is added, in both cases transgranular cleavage dominates even in the severely embrittled specimens, indicating that no more the grain boundaries and sintering necks are the weakest links in the systems.
Serum thrombopoietin levels in patients with aplastic anaemia (1996)

Endogenous serum thrombopoietin (TPO) levels were measured in 31 patients with aplastic anaemia (AA) using an enzyme immunoassay with a sensitivity of 20 pg/ ml. The median platelet count for all AA patients was 30 +/- 29 x 10(9)/l (range 5-102) compared with a median of 284 +/- 59 x 10(9)/l (range 148-538) for normal controls. Serum TPO levels were significantly elevated in all patients compared with normals (1706 +/- 1114.2, range 375-5000 v 78 +/- 54, range 16.5-312.9, P < 0.0001). There was no correlation between serum TPO levels and the degree of thrombocytopenia in AA patients, but TPO levels were significantly higher in patients who were platelet transfusion dependent than in patients who were transfusion independent (P < 0.01). There was a trend for higher TPO levels in patients with severe AA compared with non-severe AA patients. Clinical trials of TPO and a related truncated, pegylated molecule, megakaryocyte growth and development factor (PEG-rHuMGDF), are awaited to determine whether treatment with these drugs will result in increased platelet counts in patients with AA.
Clinical Assessment of a New Method for Pacing Pulse Detection Using a Hybrid Circuit in Digital Holter Monitoring (2000)

Holter monitoring is widely used for the detection of arrhythmia and ischemic episodes. Traditionally, analog amplitude-modulated Holter devices have been used for detecting arrhythmia, but they produce signal distortion due to contour effects and phase distortion caused by the tape recorders. A digital Holter device without these disadvantages has been developed and can reproduce clinically accurate electrocardiographic waveforms useful for assessment of arrhythmia and ST segments. However, their reliability is questionable when detecting pacing pulses in pacemaker patients. Because electrocardiographic signals are digitized based on sampling rate, pacing pulses are occasionally missed. Therefore, the FM-300 was developed, a new device for detecting pacing pulses on digital recordings that has both digital and analog circuits in one system and indicates pacing pulse timing with arrows. This device can automatically detect and recognize pacing pulses from various artifacts and pacing modalities, making it easy to identify pacing pulses on digitally recorded electrocardiograms. The FM-300 is useful in the diagnosis and assessment of pacemaker function and has improved the reliability of pulse detection in digital Holter monitoring.
Performance of a parallel acquisition scheme for a spread-spectrum packet radio communication (2002)

A matched-filter (MF) parallel acquisition scheme is proposed for a direct-sequence (DS) spread-spectrum (SS) packet radio communication. The parallel acquisition scheme consists of a bank of N parallel 1-Q noncoherent MF's. Autocorrelation sidelobes are considered for preamble detection. Packet loss probabilities for the acquisition scheme are derived for an AWGN and a fast Rayleigh fading channels. It is shown that autocorrelation sidelobes of PN codes degrade the performance of the acquisition scheme. Also it is shown that the parallel acquisition scheme achieves smaller packet loss probability than the serial acquisition scheme for both an AWGN and a fast Rayleigh fading channels.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Stream Attention-based Multi-array End-to-end Speech Recognition (2019)

Automatic Speech Recognition (ASR) using multiple microphone arrays has achieved great success in the far-field robustness. Taking advantage of all the information that each array shares and contributes is crucial in this task. Motivated by the advances of joint Connectionist Temporal Classification (CTC)/attention mechanism in the End-to-End (E2E) ASR, a stream attention-based multi-array framework is proposed in this work. Microphone arrays, acting as information streams, are activated by separate encoders and decoded under the instruction of both CTC and attention networks. In terms of attention, a hierarchical structure is adopted. On top of the regular attention networks, stream attention is introduced to steer the decoder toward the most informative encoders. Experiments have been conducted on AMI and DIRHA multi-array corpora using the encoder-decoder architecture. Compared with the best single-array results, the proposed framework has achieved relative Word Error Rates (WERs) reduction of 3.7% and 9.7% in the two datasets, respectively, which is better than conventional strategies as well.
Novel unity power factor circuits using zero-vector control for single-phase input systems (2000)

This paper proposes two novel circuits which realize a unity input power factor single-phase to three-phase converter with a motor load. The power supply is connected to the neutral point of the motor, and the three-phase inverter is controlled to act also as a virtual AC/DC power converter leg. This virtual leg is controlled by zero vectors of the three-phase inverter. The main features of these circuits are as follows: no inductive components are required; a reduction in the number of switching devices compared with conventional topologies; and motor current increases because converter input current also flows through the motor windings. A full-bridge converter can be built using the same number of switching devices as the conventional half bridge and with no need for a capacitive leg with an accessible neutral point. In this paper, the proposed full-bridge-type circuit is experimentally tested using a 750-W induction motor as load.
Absolute Konfiguration der isomeren 2‐Amino‐indanole‐(1) und 2‐<i>N</i>‐Isoindolinyl‐indanole‐(1) (1971)

Abstract Die vier isomeren 2‐Amino‐indanole‐(1) ( 1a, b, 2a, b ) *) werden unter Erhaltung der Konfiguration an C‐2 in (S)‐ und (R)‐2‐Phthalimido‐indanon‐(1) ( 6a, b ) übergeführt. Letztere werden ebenfalls unter Konfigurationserhalt auf einem zweiten Weg aus L ‐ und D ‐Phenylalanin ( 3a, b ) dargestellt. Damit sind die absoluten Konfigurationen aller vier isomerer 2‐Amino‐indanole‐(1) eindeutig festgelegt. (S)‐ und (R)‐2‐Phthalimido‐indanon‐(1) ( 6a, b ) werden mit Lithiumalanat zu den vier isomeren 2‐ N ‐Isoindolinyl‐indanolen‐(1) ( 10a, b, 11a, b ) reduziert, deren absolute Konfiguration damit ebenfalls sichergestellt ist.
FATAL SALT POISONING DUE TO GASTRIC LAVAGE WITH HYPERTONIC SALINE (1971)

Two children who swallowed harmless amounts of toxic substances received a gastric lavage with hypertonic saline and died several hours later from acute salt poisoning. The clinical and pathological features, typical of this condition, are presented in detail. The relatively high toxicity of ingested salt Is discussed and shown to prohibit the use of hypertonic saline for gastric lavage and to throw doubt on its use even as an emetic.
Leveraging declarative languages in web application development (2015)

Web Applications have become an omnipresent part of our daily lives. They are easy to use, but hard to develop. WYSIWYG editors, form builders, mashup editors, and markup authoring tools ease the development of Web Applications. However, more advanced Web Applications require servers-side programming, which is beyond the skills of end-user developers. In this paper, we discuss how declarative languages can simplify Web Application development and empower end-users as Web developers. We first identify nine end-user Web Application development levels ranging from simple visual customization to advanced three-tier programming. Then, we propose expanding the presentation tier to support all aspects of Web Application development. We introduce a unified XForms-based framework—called XFormsDB—that supports both client-side and server-side Web Application development. Furthermore, we make a language extension proposal—called XFormsRTC—for adding true real-time communication capabilities to XForms. We also present XFormsDB Integrated Development Environment (XIDE), which assists end-users in authoring highly interactive data-driven Web Applications. XIDE supports all Web Application development levels and, especially, promotes the transition from markup authoring and snippet programming to single and unified language programming.
Continuous Skeletons from Digitized Images (1969)

An algorithm for the determination of the skeleton of a polygonal figure is presented. The propagation of the figure contour is simulated analytically. All skeleton branch points are obtained, in an order which depends on their distance from the contour, together with the equations of the skeleton branches connecting them. The computing time for polygons with few concave vertices is roughly proportional to the number of sides.
Pharmacological properties of endothelins and big endothelins in ketamine/xylazine or urethane anesthetized rats* (1995)

Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor peptide formed through a specific conversion of its intermediate precursor, big ET-1, by an endothelin-converting enzyme (ECE). The present study evaluates the capacity of the ECE to convert the three big endothelins (big ET-1, big ET-2, and big ET-3), by comparing the pressor responses to these peptides with those induced by their respective metabolites (ET-1, -2, and -3) in the rat in vivo, anesthetized either with a mixture of ketamine/xylazine or with urethane. The mean basal arterial pressure under urethane anesthesia was not significantly different from that of ketamine/xylazine-treated animals (90/15 mg/kg; intramuscularly), although the basal heart rate was significantly higher in the former animals (urethane: 407 +/- 10 beats/min, ketamine/xylazine: 276 +/- 4 beats/min, P < .01; n = 8 to 17). In ketamine/xylazine and hexamethonium-treated rats (5-min infusion, 10 mg/kg intravenously), intravenous injection of ET-1 (1 nmol/kg) and big ET-1 (1 nmol/kg) induced potent vasopressor effects which lasted for more than 20 min. ET-2 (1 nmol/kg) produced similar pressor responses while big ET-2 (1-37) and big ET-2 (1-38) were twofold less potent than ET-2 (P < .05; n = 3 to 4). Big ET-3 induced a pressor effect only at 4 nmol/kg and was found to be at least 10 times less potent than ET-3. In animals anesthetized with urethane (1.5 g/kg intraperitoneally), the pressor responses induced by the endothelins and their intermediate precursors, as well as the pressor responses to angiotensin II and norepinephrine, were reduced by more than 60% (P < .01) when compared to ketamine/xylazine-treated animals. Big ET-3 was found inactive under urethane anesthesia. Ganglion blockade by hexamethonium did not affect the response to ET-1, big ET-1, ET-3, or big ET-3 in rats anesthetized with either ketamine/xylazine or urethane. On the other hand, big ET-2 (1-38), in contrast to ET-2 or big ET-1, did not release prostacyclin from the rat perfused lung, thus indicating that big ET-2 (1-38) is poorly converted in the pulmonary vasculature, and that the phosphoramidon-sensitive ECE responsible for the pressor effects of big ET-2 is localized elsewhere in the systemic circulation. Our results also show that the choice of anesthetics is crucial for the proper monitoring of the pressor responses to endothelins as well as other pressor agents. Nonetheless, even in what we consider as optimal conditions of anesthesia (threshold dose for the pressor response to ET-1 in ketamine/xylazine-treated rats: 0.01 nmol/kg), big ET-3 remains far less active than big ET-1 as a pressor peptide in the rat, suggesting a preferential processing of the latter by the ECE.