gebhart/patrepeval huggingface dataset:
PANIC: Modeling Application Performance over Virtualized Resources (2015)

In this work we address the problem of predicting the performance of a complex application deployed over virtualized resources. Cloud computing has enabled numerous companies to develop and deploy their applications over cloud infrastructures for a wealth of reasons including (but not limited to) decrease costs, avoid administrative effort, rapidly allocate new resources, etc. Virtualization however, adds an extra layer in the software stack, hardening the prediction of the relation between the resources and the application performance, which is a key factor for every industry. To address this challenge we propose PANIC, a system which obtains knowledge for the application by actually deploying it over a cloud infrastructure and then, approximating the performance of the application for the all possible deployment configurations. The user of PANIC defines a set of resources along with their respective ranges and then the system samples the deployment space formed by all the combinations of the resources, deploys the application in some representative points and utilizes a wealth of approximation techniques to predict the behavior of the application in the remainder space. The experimental evaluation has indicated that a small portion of the possible deployment configurations is enough to create profiles with high accuracy for three real world applications.
Enhanced Oxygen Reduction Activity of Platinum Monolayer on Gold Nanoparticles (2010)

The increase in oxygen binding energy was previously proposed to account for the lower oxygen reduction activity of a Pt monolayer supported on Au(111) single crystal than that on Pd(111) and pure Pt(111) surfaces. This single-crystal based understanding, however, cannot explain the new finding of a 1.6-fold increase of oxygen reduction activity on Pt monolayer-modified 3-nm Au nanoparticles (Pt/Au/C) in comparison with that on Pt/Pd/C with a similar particle size. The Pt/Au/C catalyst also has an activity higher than that of a state-of-the-art 2.8-nm Pt/C catalyst. Our new experimental results and density functional theory calculations demonstrate that a significant compressive strain in the surface of the core nanoparticles plays a role in the observed activity enhancement.
Profiles of healing and nonhealing Cryptosporidium parvum infection in C57BL/6 mice with functional B and T lymphocytes: the extent of gamma interferon modulation determines the outcome of infection (1997)

This study describes healing and nonhealing models of Cryptosporidium parvum infection with adult mice that have functional T and B lymphocytes. In our nonhealing model, mice on a C57BL/6 background which have a targeted disruption in the gamma interferon (IFN-gamma) gene (GKO mice) are utilized. C. parvum-infected GKO mice shed extremely high levels of oocysts and displayed overwhelming infection of the entire small intestine. The majority of these mice succumbed within 2 to 3 weeks due to severe acute infection and profound mucosal destruction. In our healing murine model, C57BL/6J mice treated with a single injection of the neutralizing anti-IFN-gamma monoclonal antibody XMG 1.2 prior to infection were used. These mice developed two peaks of oocyst shedding but were ultimately free of parasites on day 30 of infection. Again, the small intestine was the primary site of infection. Mesenteric lymph node (MLN) cells isolated from C. parvum-infected nonhealing GKO mice proliferated and secreted interleukin 2 (IL-2) but not IFN-gamma or IL-4 in response to ex vivo restimulation with intact C. parvum sporozoites or a C. parvum sporozoite antigen preparation. In contrast, parasite-specific MLN cells isolated from healing C57BL/6J mice secreted IL-2 and IFN-gamma but not IL-4. These results suggest that IFN-gamma, either directly or indirectly, is important for resistance to and resolution of cryptosporidiosis. Moreover, these models now allow the analysis of parasite-specific cell-mediated and humoral mucosal immune responses to determine what constitutes protective immunity to C. parvum.
Mechanical Oscillation Coupled with the Belousov−Zhabotinsky Reaction in Gel (2003)

We succeed in measuring the oscillating force of cylindrical poly(N-isopropylacrylamide) gel having a side group of ruthenium tris(2,2‘-bipyridine) (Ru(bpy)3) accompanied with the periodic redox reaction of Ru(bpy)32+/3+, the Belousov−Zhabotinsky (BZ) reaction. The measurements are made for three gels with different diameters, 0.65, 1.17, and 1.88 mm, at 15 °C. It is found that the amplitude of oscillatory tensile stress of the reacting cylindrical gel with a diameter of 0.65 mm is much higher than the stress theoretically expected from the Donnan osmotic pressure. The amplitude is explained by an oscillatory change of the interaction parameter, χ, which might be induced by the hydration and dehydration of the chain due to the oscillatory charge density on the polymer chain. The oscillation behavior of the BZ reaction is found to be strongly dependent on the diameter of the gel. The staying period in the oxidative state and the period of the oscillation increase with a decrease in the diameter of the cylindrical gel.
Low‐Melting, Low‐Viscous, Hydrophobic Ionic Liquids: N‐Alkyl(alkyl ether)‐N‐methylpyrrolidinium Perfluoroethyltrifluoroborate. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Imprint Characteristics by Photo-Induced Solidification of Liquid Polymer (2000)

Nanoimprint lithography is an attractive technology for LSIs era below 40-nm critical dimension from the viewpoints of high-throughput and low-cost equipment. In order to avoid a pattern placement error due to thermal expansion in the conventional thermal imprint process, we attempted to replicate the mold pattern onto a liquid polymer, which was solidified using ultra-violet (UV) light irradiation at room temperature. The liquid polymer used here was supplied by TEIJIN SEIKI Co., and termed TSR-820. It was spin coated on slide glass to produce approximately 1.5-µm-thick polymer film. The thickness remained after UV exposure and rinsing in acetone was observed at the dose of 10 J/cm 2 and it saturated about a UV exposure dose of 100 J/cm 2 with an increase in the exposure dose. The mold fabricated of quartz plate was first pressed onto the polymer film at about 100 kg/cm 2 and then the UV light was irradiated using an imprint apparatus developed for this work. After releasing the mold from the film, the substrate was rinsed in acetone to remove the residual liquid polymer. Eventually the minimum feature size of 100-nm line and 300-nm space pattern was successfully replicated in the polymer with good fidelity.
Real Estate War in Cyberspace: An Emerging Electronic Market? (1999)

In this paper, we explore how electronic commerce, the World-Wide Web in particular, is affecting the real estate industry. Real estate is a promising setting for studying electronic commerce because it is an information-intensive and informationdriven industry; transaction-based, with high value and asset-specificity; with many market-intermediaries (agents and brokers who connect buyers and sellers rather than buying or selling themselves); and experiencing on-going information technology (IT) related changes. We analyze a real estate transaction to suggest where IT might change the process of buying or selling a house and discuss several current ventures in this area. This analysis suggests that Web-based commerce is eroding the long-enjoyed information monopoly of real-estate agents and electronic commerce applications have the potential to drastically change current practices in the real-estate industry, including the disintermediation of agents. Keywords: real estate, electronic...
Using Eye Movements to Evaluate a PC-Based Risk Awareness and Perception Training Program on a Driving Simulator (2006)

The PC training program developed, which is portable and can be widely used, has great promise in improving risk perception for novice drivers on the road.
Synthetic Peptides with Antigenic Specificity for Bacterial Toxins (2007)

The attachment of a diphtheria toxin-specific synthetic antigenic determinant and a synthetic adjuvant to a synthetic polymeric carrier led to production of a totally synthetic macromolecule which provoked protective antibodies against diphtheria when administered in aqueous solution. When peptides related to the B subunit of cholera toxin were synthesized and attached to tetanus toxoid, antibodies produced against the conjugate reacted in some but not all cases with intact cholera toxin and (especially with peptide CTP 3, residues 50-64) neutralized toxin reactivity, as tested by permeability in rabbit skin, fluid accumulation in ligated small intestinal loops and adenylate cyclase activation. Polymerization of the peptide without any external carrier, or conjugation with the dipalmityl lysine group, had as good an effect in enhancing the immune response as its attachment to tetanus toxoid. Prior exposure to the carrier suppressed the immune response to the epitope attached to it, whereas prior exposure to the synthetic peptide had a good priming effect when the intact toxin was given; when two different peptides were attached to the same carrier, both were expressed. Antisera against peptide CTP 3 were highly cross-reactive with the heat-labile toxin of Escherichia coli and neutralized it to the same extent as cholera toxin, which is not surprising in view of the great homology between the two proteins. A synthetic oligonucleotide coding for CTP 3 has been used to express the peptide in a form suitable for immunization. It led to a priming effect against the intact cholera toxin.
Fructans in the diet cause alterations of intestinal mucosal architecture, released mucins and mucosa-associated bifidobacteria in gnotobiotic rats (2003)

The effects of fructans in the diet on the mucosal morphometry (height of villi, depth of the crypts, number of goblet cells), the thickness of the epithelial mucus layer and the histochemical composition of intestinal mucosubstances in the distal jejunum and the distal colon were investigated by comparing germ-free (GF) rats, rats harbouring Bacteroides vulgatus and Bifidobacterium longum (diassociated (DA) rats), and rats with a human faecal flora (HFA). The rats were fed either a commercial standard diet (ST) or ST + (50 g oligofructose (OF)-long-chain inulin (lcIN))/kg. Changes in total bacteria, bifidobacteria and Bacteroides-Prevotella in response to feeding these diets were investigated by fluorescent in situ hybridization with 16S rRNA-targeted probes both in intestinal contents (lumen bacteria) and tissue sections (mucosa-associated bacteria). The OF-lcIN-containing diet resulted in higher villi and deeper crypts in bacteria-associated, but not in GF rats. In DA and HFA rats, the colonic epithelial mucus layer was thicker and the numbers of the goblet cells were greater than in GF rats. These effects were enhanced by the OF-lcIN-containing diet. In both dietary groups, bacterial colonization of GF rats caused an increase in neutral mucins in the distal jejunum and colon. Bacteria-associated rats had more acidic mucins in the colon than GF rats, and the OF-lcIN-containing diet stimulated sulfomucins as the predominant type of acidic mucins, while sialomucins dominated in the ST-fed groups. The number of mucosa-associated bifidobacteria detected in the colon of DA and HFA rats was greater with OF-lcIN than ST (4.9 and 5.4 v. 3.5 and 4.0 log10/mm2 mucosal surface respectively), whereas the number of luminal bifidobacteria was only affected by fructans in DA rats. Bacteroides did not differ between the groups. The stabilisation of the gut mucosal barrier, either by changes in the mucosal architecture itself, in released mucins or by stimulation of mucosal bifidobacteria with fructans, could become an important topic in the treatment and prophylaxis of gastrointestinal disorders and health maintenance.
Design, Synthesis, and Bioactivities of Steroid-Linked Taxol Analogues as Potential Targeted Drugs for Prostate and Breast Cancer (2003)

The female steroid hormone 3,17beta-estradiol (2) was selected as an agent to target taxol (1) to estrogen receptor (ER) positive breast cancer cells. Estradiol-taxol conjugates (ETC) were synthesized through linkages from the 11- or 16-position of estradiol to the 2'-, 7-, or 10-position of taxol. All conjugates were cytotoxic to the A2870 ovarian cancer cell line, although less so than taxol. The MCF-7 breast cancer cell line (ER-alpha positive) and MDA-MB-231 breast cancer cell line (ER-alpha negative) were also used to evaluate the selectivity and cytotoxicity of these conjugates. One conjugate showed some selectivity for ER positive cells, but it was less potent than taxol. Two ETC hemisuccinates were also prepared to improve the solubility of the conjugates. The corresponding Na and triethanolammonium salts were slightly more cytotoxic than the acid form but were much less cytotoxic than the corresponding ETC.
Advances in Facial Rejuvenation: Botulinum Toxin Type A, Hyaluronic Acid Dermal Fillers, and Combination Therapies???-Consensus Recommendations (2008)

Optimal outcomes in facial aesthetics require in-depth knowledge of facial aging and anatomy, an appreciation that rejuvenation is a three-dimensional process involving muscle control, volume restoration, and recontouring, and thorough knowledge of properties and techniques specific to each product in the armamentarium.
Manipulation of Antioxidant Status Fails to Improve Fertility of Lactating Cows or Survival of Heat-Shocked Embryos (2003)

Experiments were conducted to test whether enhancement of antioxidant status could improve fertility and milk yield in dairy cows and resistance of cultured embryos to heat shock. Three experiments in three herds were performed to evaluate the effect of multiple intramuscular injections of 500 mg of vitamin E and 50 mg of selenium at 8 to 21 d before expected calving and at 30 and 80 d postpartum on reproduction of lactating Holstein cows. Vitamin E and selenium injections did not improve reproductive function or milk yield in any of the studies. The predicted 305-d milk yield (averages of least-squares means across treatments) were: 9478, 7073, and 10,204 kg projected 305-d milk for experiments 1, 2, and 3, respectively. Percentages of cows pregnant at first service were 30, 16, and 24% in experiments 1, 2, and 3, respectively. Three studies were performed to test whether vitamin E improved development of cultured bovine embryos exposed to heat shock. Heat shock of 41 degrees C at the two-cell stage reduced development to the blastocyst stage, but culture with 100 microM vitamin E did not reduce effects of heat shock on impaired development. For example, 9 h at 41 degrees C reduced blastocyst development from 51.2 +/- 3.3% to 3.4 +/- 3.3% in the absence of vitamin E and from 54.0 +/- 3.3% to 5.2 +/- 3.3% in the presence of vitamin E. Development of morulae to the blastocyst stage was not compromised by culture at 41 degrees C for 9 h. Additionally, there was no overall effect of vitamin E on morula development. In conclusion, multiple injections of vitamin E and selenium at the administered levels did not improve postpartum fertility nor milk yield of lactating Holstein cows in three different herds, and there was no direct thermoprotective effect of vitamin E for cultured, heat-shocked embryos.
Synthesis of Novel 4,1-Benzoxazepine Derivatives as Squalene Synthase Inhibitors and Their Inhibition of Cholesterol Synthesis (2002)

Modification of the carboxyl group at the 3-position and introduction of protective groups to the hydroxy group of the 4,1-benzoxazepine derivative 2 (metabolite of 1) were carried out, and the inhibitory activity for squalene synthase and cholesterol synthesis in the liver was investigated. Among these compounds, the glycine derivative 3a and beta-alanine derivative 3f exhibited the most potent inhibition of squalene synthase prepared from HepG2 cells (IC(50) = 15 nM). On the other hand, the piperidine-4-acetic acid derivative 4a, which was prepared by acetylation of 3j, was the most effective inhibitor of cholesterol synthesis in rat liver (ED(50) = 2.9 mg/kg, po). After oral administration, 4a was absorbed and rapidly hydrolyzed to deacylated 3j. Compound 3j was detected mainly in the liver, but the plasma level of 3j was found to be low. Compounds 3j and 4a were found to be competitive inhibitors with respect to farnesyl pyrophosphate. Further evaluation of 4a as a cholesterol-lowering and antiatherosclerotic agent is underway.
Influence of external factors on electron field emission from thin-film nanofilament carbon structures (1996)

The influence of temperature and residual gas pressure on the field emission of thin-film nanotube carbon structures has been studied. These structures are shown to exhibit low work functions. They are promising for fabrication of effective low-voltage field emitters and low-temperature thermal emitters.
Expanding the molecular toolbox for Lactococcus lactis: construction of an inducible thioredoxin gene fusion expression system (2011)

This study is the first description of a thioredoxin gene fusion expression system, purposely developed to circumvent problems associated with protein over-expression in L. lactis. It was shown to prevent protein insolubility and degradation, allowing sufficient production of soluble proteins for further structural and functional characterization.
EGFR Soluble Isoforms and Their Transcripts Are Expressed in Meningiomas (2012)

The EGFR (epidermal growth factor receptor) is involved in the oncogenesis of many tumors. In addition to the full-length EGFR (isoform a), normal and tumor cells produce soluble EGFR isoforms (sEGFR) that lack the intracellular domain. sEGFR isoforms b, c and d are encoded by EGFR variants 2 (v2), 3 (v3) and 4 (v4) mRNA resulting from gene alternative splicing. Accordingly, the results of EGFR protein expression analysis depend on the domain targeted by the antibodies. In meningiomas, EGFR expression investigations mainly focused on EGFR isoform a. sEGFR and EGFRvIII mutant, that encodes a constitutively active truncated receptor, have not been studied. In a 69 meningiomas series, protein expression was analyzed by immunohistochemistry using extracellular domain targeted antibody (ECD-Ab) and intracellular domain targeted antibody (ICD-Ab). EGFRv1 to v4 and EGFRvIII mRNAs were quantified by RT-PCR and EGFR amplification revealed by MLPA. Results were analyzed with respect to clinical data, tumor resection (Simpson grade), histological type, tumor grade, and patient outcome.Immunochemical staining was stronger with ECD-Ab than with ICD-Ab. Meningiomas expressed EGFRv1 to -v4 mRNAs but not EGFRvIII mutant. Intermediate or high ECD-Ab staining and high EGFRv1 to v4 mRNA levels were associated to a better progression free survival (PFS). PFS was also improved in women, when tumor resection was evaluated as Simpson 1 or 2, in grade I vs. grade II and III meningiomas and when Ki67 labeling index was lower than 10%. Our results suggest that, EGFR protein isoforms without ICD and their corresponding mRNA variants are expressed in meningiomas in addition to the whole isoform a. EGFRvIII was not expressed. High expression levels seem to be related to a better prognosis. These results indicate that the oncogenetic mechanisms involving the EGFR pathway in meningiomas could be different from other tumor types.
Biophoton emission of human body. (2003)

For the first time systematic measurements of the "ultraweak" photon emission of the human body (biophotons) have been performed by means of a photon detector device set up in darkness. About 200 persons have been investigated. In a particular case one person has been examined daily over several months. It turned out that this biophoton emission reflects, (i) the left-right symmetry of the human body; (ii) biological rhythms such as 14 days, 1 month, 3 months and 9 months; (iii) disease in terms of broken symmetry between left and right side; and (iv) light channels in the body, which regulate energy and information transfer between different parts. The results show that besides a deeper understanding of health, disease and body field, this method provides a new powerful tool of non-invasive medical diagnosis in terms of basic regulatory functions of the body.
Joint Segmentation and Fine-Grained Classification of Nuclei in Histopathology Images (2019)

Nuclei segmentation and classification are two important tasks in the histopathology image analysis, because the morphological features of nuclei and spatial distributions of different types of nuclei are highly related to cancer diagnosis and prognosis. Existing methods handle the two problems independently, which are not able to obtain the features and spatial heterogeneity of different types of nuclei at the same time. In this paper, we propose a novel deep learning based method which solves both tasks in a unified framework. It can segment individual nuclei and classify them into tumor, lymphocyte and stroma nuclei. Perceptual loss is utilized to enhance the segmentation of details. We also take advantages of transfer learning to promote the training of deep neural networks on a relatively small lung cancer dataset. Experimental results prove the effectiveness of the proposed method. The code is publicly available.
Evaluation of Novel Oxide Anodes for Methane Conversion in SOFC Systems (1993)

The oxidation of dry methane has been investigated over a series of semiconducting oxides using both steady state and temperature programmed techniques. Generally, the conversion to C2 compounds was low on all the highly electronically conducting samples, and at elevated temperatures (above 800 °C) all the oxides were active for complete oxidation. P-type low conductivity oxides appear to be moderately active for C2 formation, but require intermixing with a current carrying metal or cermet for SOFC application. TPRx and TPO studies on La0.8Ca0.2CrO3 reveal the involvement of surface oxygen vacancies and carbon deposition on the active sites. The oxides studied were: rutile-type Ti0.97Nb0.03O2, the pseudobrookite-type Mg0.3Nb0.1Ti2.6O5 and MgTi1.95Nb0.05O5, pyrochlore-type Sm2Ti1.9Nb0.1O7, V3O5-structure type CrTi2O5, perovskite-type La0.8Ca0.2CrO3 and Sm2O3