gebhart/patrepeval huggingface dataset:
SHARPIN-mediated regulation of protein arginine methyltransferase 5 controls melanoma growth (2017)

SHARPIN, an adaptor for the linear ubiquitin chain assembly complex (LUBAC), plays important roles in NF-κB signaling and inflammation. Here, we have demonstrated a LUBAC-independent role for SHARPIN in regulating melanoma growth. We observed that SHARPIN interacted with PRMT5, a type II protein arginine methyltransferase, and increased its multiprotein complex and methyltransferase activity. Activated PRMT5 controlled the expression of the transcription factors SOX10 and MITF by SHARPIN-dependent arginine dimethylation and inhibition of the transcriptional corepressor SKI. Activation of PRMT5 by SHARPIN counteracted PRMT5 inhibition by methylthioadenosine, a substrate of methylthioadenosine phosphorylase, which is codeleted with cyclin-dependent kinase inhibitor 2A (CDKN2A) in approximately 15% of human cancers. Collectively, we identified a LUBAC-independent role for SHARPIN in enhancing PRMT5 activity that contributes to melanomagenesis through the SKI/SOX10 regulatory axis.
Modulation of Epstein-Barr Virus Latent Membrane Protein 1 Activity by Intrabodies (2007)

These data indicate that scFv H3 intrabody can inhibit LMP1 functions in epithelial cells and may be useful for attenuating the LMP1 function in LMP1-positive tumors.
WATER MEDIATION IN PROTEIN FOLDING AND MOLECULAR RECOGNITION (2006)

Water is essential for life in many ways, and without it biomolecules might no longer truly be biomolecules. In particular, water is important to the structure, stability, dynamics, and function of biological macromolecules. In protein folding, water mediates the collapse of the chain and the search for the native topology through a funneled energy landscape. Water actively participates in molecular recognition by mediating the interactions between binding partners and contributes to either enthalpic or entropic stabilization. Accordingly, water must be included in recognition and structure prediction codes to capture specificity. Thus water should not be treated as an inert environment, but rather as an integral and active component of biomolecular systems, where it has both dynamic and structural roles. Focusing on water sheds light on the physics and function of biological machinery and self-assembly and may advance our understanding of the natural design of proteins and nucleic acids.
Reblur2Deblur: Deblurring Videos via Self-Supervised Learning (2018)

Motion blur is a fundamental problem in computer vision as it impacts image quality and hinders inference. Traditional deblurring algorithms leverage the physics of the image formation model and use hand-crafted priors: they usually produce results that better reflect the underlying scene, but present artifacts. Recent learning-based methods implicitly extract the distribution of natural images directly from the data and use it to synthesize plausible images. Their results are impressive, but they are not always faithful to the content of the latent image. We present an approach that bridges the two. Our method fine-tunes existing deblurring neural networks in a self-supervised fashion by enforcing that the output, when blurred based on the optical flow between subsequent frames, matches the input blurry image. We show that our method significantly improves the performance of existing methods on several datasets both visually and in terms of image quality metrics. The supplementary material is https://goo.gl/nYPjEQ
Evaluation of Dressing Regimens for Prevention of Infection With Peripheral Intravenous Catheters (1987)

Four dressing regimens for peripheral venous catheters were studied in a prospective randomized clinical trial with 2088 Teflon catheters: (1) sterile gauze, replaced every other day, and three dressings left on for the lifetime of the catheter; (2) gauze; (3) a transparent polyurethane dressing; and (4) an iodophor-transparent dressing. The four dressings provided comparable coverage, except moisture accumulated more frequently under the transparent dressings 26% to 28% vs 20% to 21% Cutaneous colonization under the dressing was low level and comparable with all four dressings (range, 100.58 to 100.70 colony-forming units). The rate of local catheter-related infection ≥15 colony-forming units) was also low and did not differ significantly (range, 4.6% to 5.9%); no catheter caused bacteremia. Stepwise logistic multivariate analysis showed cutaneous colonization of the insertion site (relative risk [RR] of infection, 3.86), contamination of the catheter hub (RR, 3.78), moisture under the dressing (RR, 2.48), and prolonged catheterization (RR, 1.75) to be significant risk factors for catheter-related infection. These data indicate that it is not cost-effective to redress peripheral venous catheters at periodic intervals; for most patients, either sterile gauze or a transparent dressing can be used and left on until the catheter is removed. (<i>JAMA</i>1987;258:2396-2403)
ABF++: fast and robust angle based flattening (2005)

Conformal parameterization of mesh models has numerous applications in geometry processing. Conformality is desirable for remeshing, surface reconstruction, and many other mesh processing applications. Subject to the conformality requirement, these applications typically benefit from parameterizations with smaller stretch. The Angle Based Flattening (ABF) method, presented a few years ago, generates provably valid conformal parameterizations with low stretch. However, it is quite time-consuming and becomes error prone for large meshes due to numerical error accumulation. This work presents ABF&plus;&plus;, a highly efficient extension of the ABF method, that overcomes these drawbacks while maintaining all the advantages of ABF. ABF++ robustly parameterizes meshes of hundreds of thousands and millions of triangles within minutes. It is based on three main components: (1) a new numerical solution technique that dramatically reduces the dimension of the linear systems solved at each iteration, speeding up the solution; (2) a new robust scheme for reconstructing the 2D coordinates from the angle space solution that avoids the numerical instabilities which hindered the ABF reconstruction scheme; and (3) an efficient hierarchical solution technique. The speedup with (1) does not come at the expense of greater distortion. The hierarchical technique (3) enables parameterization of models with millions of faces in seconds at the expense of a minor increase in parametric distortion. The parameterization computed by ABF++ are provably valid, that is they contain no flipped triangles. As a result of these extensions, the ABF++ method is extremely suitable for robustly and efficiently parameterizing models for geometry-processing applications.
Structure-Activity Relationship of Indole-Tethered Pyrimidine Derivatives that Concurrently Inhibit Epidermal Growth Factor Receptor and Other Angiokinases (2015)

Antiangiogenic agents have been widely investigated in combination with standard chemotherapy or targeted cancer agents for better management of advanced cancers. Therapeutic agents that concurrently inhibit epidermal growth factor receptor and other angiokinases could be useful alternatives to combination therapies for epidermal growth factor receptor-dependent cancers. Here, we report the synthesis of an indole derivative of pazopanib using a bioisosteric replacement strategy, which was designated MKP101. MKP101 inhibited not only the epidermal growth factor receptor with an IC50 value of 43 nM but also inhibited angiokinases as potently as pazopanib. In addition, MKP101 effectively inhibited vascular endothelial growth factor-induced endothelial proliferation, tube formation, migration of human umbilical vein endothelial cells and proliferation of HCC827, an epidermal growth factor receptor-addicted cancer cell line. A docking model of MKP101 and the kinase domain of the epidermal growth factor receptor was generated to predict its binding mode, and validated by synthesizing and evaluating MKP101 derivatives. Additionally, a study of structure-activity relationships of indolylamino or indolyloxy pyrimidine analogues derived from MKP101 demonstrated that selectivity for epidermal growth factor receptor and other angiokinases, especially vascular endothelial growth factor receptor 2 depends on the position of substituents on pyrimidine and the type of link between pyrimidine and the indole moiety. We believe that this study could provide a basis for developing angiokinase inhibitors having high affinity for the epidermal growth factor receptor, from the pyrimidine scaffold.
Tilling the chromatin landscape: emerging methods for the discovery and profiling of protein–DNA interactions (2005)

Interactions between protein and DNA are essential for cellular function. The incremental process of developing global approaches to study chromatin began with the in vitro characterization of chromatin structural components and modifications of the versatile chromatin immunoprecipitation (ChIP) assay, capable of analyzing protein-DNA interactions in vivo. Among the emerging global approaches are ChIP cloning, ChIP display, differential chromatin scanning, ChIP-chip, DamID chromatin profiling, and chromatin array. These methods have been used to assess transcription-factor binding and (or) histone modification. This review describes these global methods and illustrates their potential in answering biological questions.
Social and Antisocial [3 + 3] Schiff Base Macrocycles with Isomeric Backbones (2008)

Two new conjugated macrocycles have been prepared in high yield using Schiff base condensation. These are the first Schiff base macrocycles to incorporate phenanthrene, and they contain 66 and 78 atoms, respectively, in their smallest closed ring. Although the backbones of the two macrocycles have nearly the same constitution, one aggregates in chloroform while the other does not. This is rationalized based on the differential overlap of aromatic components in the dimers.
Inversion of vertical seismic profiles by iterative modeling (1985)

Abstract I present an application of iterative modeling to the inversion of vertical seismic profiles (VSPs). This method is derived from linear inversion which allows the extraction from VSP data of an impedance profile as a function of time and thus permits the prediction of impedance ahead of the drill bit. There are two steps in this process: first, detection of the major events on the seismogram which is achieved by a recursive detection algorithm; and second, an optimal estimate of the impedances carried out by a gradient algorithm. Seismic data are band-limited, and consequently the solution of the inversion is nonunique. This nonuniqueness is handled by assuming a piecewise-constant or blocked impedance model and by adding a priori constraints. Some synthetic examples are used to illustrate the method, and a field example shows a comparison between an impedance profile extracted from VSP data with this inversion method and an impedance profile from well logging data. In this example the accurate prediction of impedance values illustrates the usefulness of the method.
Nonlinear fiber amplifier with tunable transform limited pulse duration from a few 100 to sub-100-fs at watt-level powers (2014)

We report a fiber amplifier system with an output transform limited pulse duration that is broadly tunable from 400 to 60 fs. We produce <100 fs pulses with >200 kW of peak power by compensating a significant amount of third-order dispersion. The spectral noise characteristics are also investigated to insure highly stable supercontinuum generation.
Controlling mouse pointer position using an infrared head-operated joystick (2000)

This paper describes the motivation for and the design considerations of a low-cost head-operated joystick. The paper briefly summarizes the requirements of head-operated mouse pointer control for people with disabilities before discussing a set of technological approaches that can be used to satisfy these requirements. The paper focuses on the design of a head-operated joystick that uses infrared light emitting diodes (LED's) and photodetectors to determine head position, which is subsequently converted into signals that emulate a Microsoft mouse. There are two significant findings. The first is that, while nonideal device characteristics might appear to make the joystick difficult to use, users naturally compensate for nonlinearities, in a transparent manner, because of visual feedback of mouse pointer position. The second finding, from relatively informal, independent trials, indicates that disabled users prefer a head-operated device that has the characteristics of a joystick (a relative pointing device) to those of a mouse (an absolute pointing device).
A Nickel‐Based Perovskite Catalyst with a Bimodal Size Distribution of Nickel Particles for Dry Reforming of Methane (2018)

Abstract The critical problem facing Ni‐based catalysts for the CO 2 reforming of methane (DRM) is the serious carbon deposition and metal sintering, which are sensitive to the size of Ni particles. A perovskite‐type catalyst La 0.46 Sr 0.34 Ti 0.9 Ni 0.1 O 3 (denoted as LSTN0.1) with a bimodal size distribution of Ni particles was prepared by combustion method. Under mild DRM conditions (CH 4 :CO 2 =1:1.2 at 700 °C), no coke was found on LSTN0.1 after 100 h reaction, and the comparison with the impregnated catalysts showed that the carbon resistance is closely associated with the strong metal–support interaction and basicity. Nevertheless, under harsh reaction conditions (CH 4 :CO 2 =2:1 at 700 °C), the coking process speeded up on LSTN0.1. This bimodal Ni catalyst had higher coke resistance than the catalyst possessing few small particles. Moreover, the coke was found on the large Ni particles (14.5 nm average size) but the small Ni particles (2.5 nm average size) remained unchanged.
Investigation of RuTiN and RuTiO diffusion barrier suggested by a new design concept for future high-density memory capacitors (2002)

As a new design concept for high-density memory capacitors, we proposed both RuTiN (RTN) and the RuTiO (RTO) materials as sacrificial oxygen diffusion barriers. The sheet resistance of the newly developed RuTiN and RuTiO barriers after oxidation was much lower than that of polycrystalline nitride and ternary amorphous barriers reported by others. For the Pt/barrier/TiSi/sub x//n/sup ++/poly-plug/n/sup +/ channel layer/Si contact structure, contact resistance was below 5 kohm even after annealing up to 750/spl deg/C. Correspondingly, the new RuTiN and RuTiO films, as diffusion barriers for oxygen, are very promising materials for high-density capacitors.
Observation of transient charge relaxation of oil within a cylindrical vessel (2002)

An experimental investigation of transient charge decay in a vessel partially filled with electrically charged liquid is reported. The test facility is an upright cylindrical tank with diameter and height equal to 50 cm. It is instrumented to permit continuous measurement of both the bulk charge density in the liquid and the electrostatic field during experimental runs. By correlating the time course of the bulk charge density to that of the electrostatic field, the transient redistribution of electrostatic charge can be characterized. One objective of this research is to ascertain the role played by surface charge in controlling the transient decay.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Graph Theory and Interconnection Networks (2008)

The advancement of large scale integrated circuit technology has enabled the construction of complex interconnection networks. Graph theory provides a fundamental tool for designing and analyzing such networks. Graph Theory and Interconnection Networks provides a thorough understanding of these interrelated topics. After a brief introduction to gra
High-Efficiency Asymmetric Forward-Flyback Converter for Wide Output Power Range (2016)

This paper proposes an asymmetric forward-flyback dc-dc converter that has high power-conversion efficiency η <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">e</sub> over a wide output power range. To solve the problem of ringing in the voltage of the rectifier diodes and the problem of duty loss in the conventional asymmetric half-bridge (AHB) converter, the proposed converter uses a voltage doubler structure with a forward inductor L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">f</sub> in the second stage, instead of using the transformer leakage inductance, to control output current. L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">f</sub> resonates with the capacitors in the voltage doubler to achieve a zero-voltage turnon of switches and a zero-current turn-off of diodes for a wide output power range. The proposed converter could operate at a wider input voltage range than the other AHB converters. η <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">e</sub> was measured as 95.9% at output power P <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">O</sub> = 100 W and as 90% at P <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">O</sub> = 10 W, when the converter was operated at input voltage 390 V, output voltage 142 V, and switching frequency 100 kHz.
Model-based inference of cognitive processes from unobtrusive gait velocity measurements (2010)

In this paper we describe a preliminary modeling and analysis of a unique data set comprising unobtrusive and continuous measurements of gait velocity in the elder participants' residences. The data have been collected as a part of a longitudinal study aimed at early detection of cognitive decline. We motivate these analyses by first presenting evidence that suggests significant relationship between gait parameters and cognitive functions. We then describe a simple, model-based approach to the analysis of gait velocity using a weighted correlation function estimates. One of the main challenges is due to the fact that the daily estimates of the gait parameters vary with the number of walks. We illustrate the importance of using weighted as opposed to unweighted estimates on a sample of different houses. The correlation functions appear to capture behavioral differences that can be related to the cognitive functioning of the participants.
Interaction between Light Quality and Light Quantity in the Photoregulation of Anthocyanin Production (1990)

The interaction between phytochrome photoequilibrium (phi) and photon flux in the photoregulation of anthocyanin production under prolonged irradiation was studied in seedlings of Brassica oleracea L. and Lycopersicon esculentum Mill. In cabbage, anthocyanin production increases with decreasing phi, reaching a maximum at the lowest value (phi = 0.13) used in this study; in tomato, the extent of the response is higher at intermediate values, reaching a maximum at phi = 0.46. In cabbage, the response increases with increasing photon flux at all phi values; however, the response to changes in photon flux is minimal at phi = 0.85, and, at phi = 0.13, minimal at photon fluxes higher than 5 micromolar per square meter per second. In tomato, the response increases with increasing photon flux at phi = 0.46, 0.65, and 0.85, the response to changes in photon fluxes being minimal at phi = 0.85; at phi = 0.13 and 0.29 the response first increases (significantly at phi = 0.29 and minimally at phi = 0.13) and then decreases with increasing photon fluxes, the transition occurring at about 1 micromolar per square meter per second at phi = 0.13, and at 5 micromolar per square meter per second at phi = 0.29. The patterns of light quality-quantity interaction in the photoregulation of anthocyanin production are significantly different in cabbage and tomato and are also significantly different than those observed for other photomorphogenic responses to prolonged irradiations.
Preparation of Ceramic Foams from Metakaolin-Based Geopolymer Gels (2009)

This chapter contains sections titled: Abstract Introduction Results and Discussion Conclusions Acknowledgements References
Risques professionnels dans la fabrication des semi-conducteurs (2014)

La fabrication des semi-conducteurs utilise de nombreux produits chimiques dont certains sont toxiques. Ce travail a pour objectif d'améliorer la connaissance de ces risques professionnels en établissant un état des lieux international, comparé ensuite aux données nationales issues des centres de consultations en pathologies professionnelles (CCPP). Ceci a été réalisé grâce à une revue de la littérature scientifique associée à une analyse comparée de la base de données du RNV3P (Réseau National de Vigilance et de Prévention des Pathologies Professionnelles). Les résultats montrent l omniprésence des agents chimiques mais avec des niveaux d exposition très faibles. Peu d informations sont disponibles sur les effets du mélange des agents chimiques et des sous-produits. Des cas d hémopathies malignes sont retrouvés dans la bibliographie (sans cause professionnelle avérée) et par le RNV3P. Le risque de fausses couches spontanées, attribué essentiellement aux éthylènes glycol (substitués en France), est plus plausible, sans cas retrouvé dans le RNV3P. Les pathologies dues aux risques psycho-sociaux (RPS) et les troubles musculo-squelettiques (TMS) sont les plus représentées et imputables à une nuisance professionnelle dans le RNV3P, contrastant avec un nombre très restreint d études publiées sur ces sujets. Une vigilance doit être portée sur les hémopathies malignes mais aussi de manière équivalente sur les RPS et les TMS ainsi que sur l amélioration des connaissances des sous-produits.
1-W single-mode edge-emitting DBR ring oscillators (1993)

The distributed Bragg reflector (DBR) ring oscillator, a class of single-mode diode laser that emits high-power, spatially coherent, single-frequency output from a large aperture, is discussed. Specifically an edge-emitting DBR ring oscillator that exhibits single frequency operation to 1 W output from a single facet is discussed. From a second device, the far field radiation pattern is a 0.20 degrees diffraction-limited beam which remains stable and stationary up to 460 mW, measured from an uncoated facet. This device produces over 2.5 W of coherent power into four equal beams and has a threshold current density of 177 A/cm/sup 2/ and a differential quantum efficiency of 63%.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Deductive parsing with multiple levels of representation (1988)

This paper discusses a sequence of deductive parsers, called PAD1 -- PAD5, that utilize an axiomatization of the principles and parameters of GB theory, including a restricted transformational component (Move-α). PAD2 uses an inference control strategy based on the 'freeze' predicate of Prolog-II, while PAD3 -- 5 utilize the Unfold-Fold transformation to transform the original axiomatization into a form that functions as a recursive descent Prolog parser for the fragment.