gebhart/patrepeval huggingface dataset:
Formation and actions of 20-hydroxyeicosatetraenoic acid in rat renal arterioles (1996)

The present study examined whether preglomerular arterioles of the rat produce 20-hydroxyeicosatetraenoic acid (20-HETE) and whether 20-HETE is vasoactive on these vessels. Raf preglomerular arterioles produced 20-HETE (4.8 +/- 1.0 pmol.min-1.mg-1, n = 7) and, to a lesser extent, 14-, 15-, 11-, and 12-dihydroxyeicosatetraenoic acid, 6-ketoprostaglandin F/alpha and prostaglandin E2 when incubated with [14C]larachidonic acid. The results of immunoblotting and reverse-transcription polymerase chain reaction experiments indicate that these vessels express mRNA and protein for a P-450 4A2 enzyme. With the use of a rat juxtamedullary nephron microvascular preparation perfused in vitro with a cell-free media, addition of 20-HETE (1 nM-1 microM) to the bath reduced the diameter of proximal and distal portions of the efferent arterioles. At a concentration of 1 microM, the diameter of the proximal and distal portions of the afferent arteriole fell by 14 +/- 1 and 16 +/- 3% after 20-HETE. The response to 20-HETE (1 microM) was not altered by blockade of cyclooxygenase, lipoxygenase, and p-450 pathways. Blockade of the large-conductance Ca(2+)-activated K+ channel with tetraethylammonium (1 mM) reduced the diameter of afferent arterioles by 10% and blocked the vasoconstrictor response to 20-HETE (1 microM). These results indicate that 20-HETE is an endogenous constrictor of preglomerular arterioles and suggest a role for the P-450 4A2 enzyme in the regulation of renal vascular tone.
Stress controlled pulsed direct current co-sputtered Al<sub>1−x</sub>Sc<sub>x</sub>N as piezoelectric phase for micromechanical sensor applications (2015)

Identifying and overcoming the interface originating c-axis instability in highly Sc enhanced AlN for piezoelectric
Pazopanib Reveals a Role for Tumor Cell B-Raf in the Prevention of HER2+ Breast Cancer Brain Metastasis (2010)

The data identify a new activity for pazopanib directly on tumor cells as a pan-Raf inhibitor and suggest its potential for prevention of brain metastatic colonization of HER2(+) breast cancer.
Traumatic Brain Injury — Football, Warfare, and Long-Term Effects (2010)

In late July, the National Football League introduced a new poster to be hung in league locker rooms, warning players of possible long-term health effects of concussions. Public awareness of the pathological consequences of traumatic brain injury has been elevated not only by the recognition of the potential clinical significance of repetitive head injuries in such high-contact sports as American football and boxing, but also by the prevalence of vehicular crashes and efforts to improve passenger safety features, and by modern warfare, especially blast injuries. Each year, more than 1.5 million Americans sustain mild traumatic brain injuries with no loss . . .
Biliary phosphatidylcholine and lysophosphatidylcholine profiles in sclerosing cholangitis (2013)

PC and LPC profiles being similar in patients with or without sclerosing cholangitis, these phospholipids are likely not of major pathogenetic importance in this disease group.
Synthesis and structure of zirconium complex [Me2C(C5H4)(Flu)Zr(.mu.-H)Cl]2, an .eta.3:.eta.5-bonded ansa-metallocene (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and structure of zirconium complex [Me2C(C5H4)(Flu)Zr(.mu.-H)Cl]2, an .eta.3:.eta.5-bonded ansa-metalloceneManfred Bochmann, Simon J. Lancaster, Michael B. Hursthouse, and Muhammed MazidCite this: Organometallics 1993, 12, 12, 4718–4720Publication Date (Print):December 1, 1993Publication History Published online1 May 2002Published inissue 1 December 1993https://pubs.acs.org/doi/10.1021/om00036a002https://doi.org/10.1021/om00036a002research-articleACS PublicationsRequest reuse permissionsArticle Views124Altmetric-Citations43LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Spray Coating Technology (2008)

Spray coating is a versatile surface modification technology in which coating is built-up based on the successive deposition of micron-scaled particles. Depending on the coating materials, the coatings can meet the required mechanical properties, corrosion resistance, and other properties of base materials. Spraying processes are mainly classified into thermal and kinetic spraying according to their bonding mechanism and deposition characteristics. Specifically, thermal spraying process can be further classified into many categories based on the design and mechanism of the process, such as frame spraying, arc spraying, atmospheric plasma spraying (APS), and high velocity oxygen-fuel (HVOF) spraying, etc. Kinetic spraying or cold gas dynamic spraying is a newly emerging coating technique which is low-temperature and high-pressure coating process. In this paper, overall view of thermal and kinetic spray coating technologies is discussed in terms of fundamentals and industrial applications. The technological characteristics and bonding mechanism of each process are introduced. Deposition behavior and properties of technologically remarkable materials are reviewed. Furthermore, industrial applications of spray coating technology and its potentials are prospected.
Experimental and modeling studies on enhancing the thermodynamic hydrate inhibition performance of monoethylene glycol via synergistic green material (2021)

This paper presents an experimental and modeling studies on the thermodynamic inhibition effects of the mixture of monoethlyene glycol (MEG) and glycine (Gly) on the carbon dioxide hydrate phase boundary condition. The monoethlyene glycol and glycine (1:1) mixture inhibition effects were investigated at concentrations of 5, 10, and 15 wt.% and pressure ranges from 2.0-4.0 MPa. The effects of the proposed mixture on the carbon dioxide hydrate phase boundary were evaluated by measuring the dissociation temperature of carbon dioxide hydrate using a T-cycle method. The synergistic effect was evaluated based on comparison with pure MEG and Gly data. The results show that 15 wt.% of MEG and Gly mixture displays the highest inhibition effect compared to the 5 and 10 wt.% mixtures, respectively. However, the synergistic effect is higher at 10 wt.%. Dickens' model was also adopted to predict the phase equilibrium data of CO<sub>2</sub> hydrates in the presence of the mixture. The modified model successfully predicted the data within a maximum error of ± 0.52 K.
NON-PARAMETRIC ACQUISITION OF NEAR-DIRAC PIXEL CORRESPONDENCES (2012)

Many computer vision and graphics applications require the acquisition of correspondences between the pixels of a 2D illumination pattern and those of captured 2D photographs. Trivial cases with only one-to-one correspondences require only a few measurements. In more general scenes containing complex inter-reflections, capturing the full reflection field requires more extensive sampling and complex processing schemes. We present a method that addresses the middle-ground: scenes where each pixel maps to a small, compact set of pixels that cannot easily be modeled parametrically. The coding method is based on optically-constructed Bloom filters and frequency coding. It is non-adaptive, allowing fast acquisition, robust to measurement noise, and can be decoded with only moderate computational power. It requires fewer measurements and scales up to higher resolutions more efficiently than previous methods.
Development of x-ray nanodiffraction instrumentation for studies of individual nano-objects (2005)

X-ray nanodiffraction was developed to study individual crystalline nano-objects at the Advanced Photon Source (APS). This technique allows nondestructive structural characterization of individual nano-objects with the advantages of high structural sensitivity and high penetration. Using the extremely high brightness of a third-generation synchrotron radiation source and hard x-ray phase zone-plate optics, we have focused hard x-rays to a microbeam of less than 200 nm during routine operation so that significant diffraction can be measured from a single tin oxide nanowire (cross section down to 24 nm × 10 nm). In this paper, we will describe the experimental technique in detail and present the results of a structural study of a few tin oxide nanowires.
Frequency and Specificity of Protamine Antibodies in Diabetic and Control Subjects (1988)

Protamines are cationic fish chromosomal proteins that retard absorption of isophane (NPH) insulins. Protamines are also administered in large doses for heparin neutralization in cardiac procedures. This study used a rapid enzyme-linked immunosorbent assay to examine frequency of protamine antibodies in diabetic and control populations. Antigen specificity of the IgG binding to protamine-coated plates was verified by competitive inhibition with other protamines, histone, glucagon, thyroid-stimulating hormone, arginine, and lysine. All antibodies tested cross-reacted completely with all protamines. Only 4 of 18 had any cross-reactivity with histones. None cross-reacted with the other inhibitors. In population surveys, 122 (38%) of 319 NPH insulin-treated diabetic subjects, 3 (8%) of 39 diabetic subjects treated with protamine-free lente insulins, and 5 (2.5%) of 202 normal control subjects had protamine antibody. No correlation was found between insulin and protamine antibodies. Because more than one-third of insulin-treated diabetic subjects have circulating IgG specific for protamine, they are potentially at risk for acute immunologic or anaphylactoid reactions when protamine is administered for heparin neutralization.
The AML1/ETO fusion protein blocks transactivation of the GM-CSF promoter by AML1B. (1995)

The t(8;21) translocation, commonly found in acute myelogenous leukemia (AML), generates a fusion protein containing N-terminal AML1 and C-terminal ETO amino acids. The human AML1 gene encodes several related proteins that specifically bind to the sequence TGT/cGGT, located in the promoter regions of a variety of hematopoietic growth factor genes. To examine the abilities of the AML1B protein (which contains 479 amino acids), a shorter AML1A isoform (which contains amino acids 1-250), and the AML1/ETO fusion protein (which contains AML1A amino acids 1-177) to stimulate transcription from the GM-CSF promoter, we performed co-transfection experiments in T cells using a human GM-CSF promoter-CAT reporter gene plasmid and expression vectors that contain the cDNAs for one of the above proteins. Our data demonstrate that AML1B, but not AML1A or AML1/ETO transactivates the GM-CSF promoter, requiring the TGTGGT sequence contained between base pairs -68 and -53. Furthermore, we show that AML1/ETO, but not AML1A, inhibits the ability of AML1B to stimulate CAT expression. Electrophoretic mobility shift assays demonstrated the specific binding of AML1 proteins to the GM-CSF promoter TGTGGT sequence, which does not require GM-CSF sequences immediately upstream of this binding site. Our data support a role for AML1B as a transcriptional activator and establish that the AML1/ETO fusion protein can act as a dominant negative protein on the human GM-CSF promoter. Although AML1/ETO does not stimulate the transcription of GM-CSF, it may function by inhibiting the normal activity of AML1B in AML cells with the t(8;21) translocation.
Cloning and partial characterization of two chromosomal loci from Bacteroides ovatus that contain genes essential for growth on guar gum (1992)

Previously, we isolated three transposon insertion mutants of Bacteroides ovatus (M-4, M-5, and M-7) that were unable to grow on the branched polysaccharide guar gum. In this study, we used a tetracycline resistance gene on the transposon to clone chromosomal DNA adjacent to the transposon insertions in each of the three mutants. Restriction analysis of the flanking chromosomal DNA in M-4 and M-7 revealed that the insertions in these two mutants were in the same location. The cloned DNA adjacent to the insertions in M-5 and M-7 was used as a hybridization probe to clone the wild-type loci. Two clones of about 10 kbp in size were obtained. Restriction analysis showed that these two clones did not overlap. The clone of the M-5 locus appeared to contain all of the genes affected by the M-5 insertion, but we were unable to demonstrate complementation of the M-5 mutation because of the instability of the clone in this background. Analysis of the clone of the M-7 locus showed that it contained a guar gum-regulated promoter, but the transcript originating from this promoter was not affected by the transposon insertion. Thus, the M-7 locus apparently contains at least two separate transcriptional units, the one defined by this promoter and the one interrupted by the transposon insertion. Insertion mutations downstream of the guar gum-regulated promoter demonstrated that there were essential guar gum utilization genes in this region. The M-7 mutant was eliminated by the wild type in the intestinal tracts of germfree mice.(ABSTRACT TRUNCATED AT 250 WORDS)
Guide wire tracking in interventional radiology (2000)

A method is presented to aid the extraction and tracking of guide wires during X-ray fluoroscopy guided endovascular interventions. A two-step procedure is utilized, in which rst a rigid translation is determined to capture the rough displacement and next a spline optimization is performed for accurate localization of the guide wire. Both the application of subtraction images and lters which enhance line-like structures are investigated. With the optimal settings, the guide wire was tracked succesfully in 141 out of 146 frames from 5 image sequences.
Implementation of an OpenVG Rasterizer with Configurable Anti-Aliasing and Multi-Window Scissoring (2006)

This paper describes an OpenVG-compliant hardware rasterizer with configurable anti-aliasing and multi-window scissoring. This rasterizer requires 129K logic gates with 2KB on-chip SRAM and provides satisfactory image quality with a reasonable rasterizer speed at the operational frequency of 100MHz. In this paper, we propose an optimized scanline algorithm, which provides better performance than the conventional scanline algorithm with supersampline while maintaining the flexibility and the hardware simplicity. We also propose a fast LUT-based scissoring algorithm, which has zero-latency in most of the cases. The hardware implementation of this rasterizer is explained in detail.
The disintegration of micro‐organisms by shaking with glass beads (1960)

Abstract A new vibrator, commercially available as the Sonomec Wave‐Pulse Generator, is described, in which micro‐organisms may be disrupted by shaking with glass beads. The amplitude and frequency of vibration of the shaker may be varied independently by suitable linkages incorporated in the mechanism. A study has been made of the effect of several variables, particularly the height of the liquid column in the vibrating container, on the rate of disruption. A relation is shown to exist between the acoustic heating produced in the container by the passage of sound waves through the liquid and the rate of disruption of baker's yeast. It is considered that at most depths of the liquid column, the action is similar to that of other shakers, but at a certain depth of liquid, additional forces arise which greatly increase the rapidity of disruption. How these forces act is not known. Factors affecting the rate of disruption of baker's yeast, Corynebacterium xerosis and Bacillus megatherium have been studied and a comparison has been made of the fractions obtained by differential centrifugation of the cell dispersion and compared with similar preparations from the Hughes press.
Efficient semantics-aware reconciliation for optimistic write sharing (2002)

The IceCube system provides near-optimal reconciliation for optimistically-replicated data. Optimistic replication lets multiple users write to shared data with no remote synchronisation, thus allowing decentralised access immune to network latency and isolation. However such replicas diverge and must be reconciled. Reconciliation depends on the semantics of the shared data and the intents of the users. In IceCube, both applications and shared data types advertise the true dependencies between update actions. IceCube suggests reconciliation schedules that respect these dependencies, using a heuristic search algorithm. IceCube is an application-independent system that enables seamless reconciliation across diverse applications and data types. It has a simple, high-level API that can express a wide range of semantics. It drastically simplifies the development of a reconcilable application. This paper presents the IceCube system in depth and reports on application experience. Evaluation using realistic benchmarks indicates that IceCube runs at reasonable speeds and scales to large input sets.
Experimental investigation of inductorless, single-stage boost rectification for sub-mW electromagnetic energy harvesters (2011)

This paper demonstrates single-stage boost rectification for electromagnetic energy harvesters down to approximately 100 μW using practical low-power techniques. The circuits exploit the inductance of the generator, and operate without a discrete inductor, which facilitates integration. Experimental results demonstrate the importance of switching device selection, and the compound effect of the duty ratio on energy harvester output power and converter efficiency, as a function of load current. The circuits demonstrate up to 84.1% harvester utilization at the maximum extractable harvester power of 141 μW, and conversion efficiencies of 73.3% and 59.4% for half- and full-wave operation respectively, neglecting gate drive losses.
Prognosis of Treatment Response (Pathological Complete Response) in Breast Cancer (2012)

Pertaining to the female population in the USA, breast cancer is the leading cancer in terms of annual incidence rate and, in terms of mortality, the second most lethal cancer. There are currently no biomarkers available that can predict which breast cancer patients will respond to chemotherapy with both sensitivity and specificity > 80%, as mandated by the latest FDA requirements. In this study, we have developed a prognostic biomarker model (complex mathematical function) that-based on global gene expression analysis of tumor tissue collected during biopsy and prior to the commencement of chemotherapy-can identify with a high accuracy those patients with breast cancer (clinical stages I-III) who will respond to the paclitaxel-fluorouracil-doxorubicin-cyclophosphamide chemotherapy and will experience pathological complete response (Responders), as well as those breast cancer patients (clinical stages I-III) who will not do so (Non-Responders). Most importantly, both the application and the accuracy of our breast cancer prognostic biomarker model are independent of the status of the hormone receptors ER, PR, and HER2, as well as of the ethnicity and age of the subjects. We developed our prognostic biomarker model with 50 subjects [10 responders (R) and 40 non-responders (NR)], and we validated it with 43 unknown (new and different) subjects [10 responders (R) and 33 non-responders (NR)]. All 93 subjects were recruited at five different clinical centers around the world. The overall sensitivity and specificity of our prognostic biomarker model were 90.0% and 91.8%, respectively. The nine most significant genes identified, which comprise the input variables to the mathematical function, are involved in regulation of transcription; cell proliferation, invasion, and migration; oncogenesis; suppression of immune response; and drug resistance and cancer recurrence.
Experimental Verification of IQ Imbalance Monitor for High-Order Modulated Transceivers (2018)

The in-service transceiver imperfection monitor based on 4×4 real-valued equalizer is experimentally verified in 42GBaud DP-64QAM system where various impairments exist simultaneously. The interaction between different impairments is discussed and the corresponding countermeasure is verified.
Evaluation of a Social Media Campaign Designed to Increase Awareness of Thirdhand Smoke among California Adults (2021)

Despite a growing body of research outlining the harms of thirdhand smoke (THS), the public remains generally unaware of risks and exposure routes. This project built on past tobacco prevention campaigns and the tenants of McGuire's input-output model to implement and evaluate a seven-month Facebook-disseminated campaign seeking to improve THS awareness among California adults (<i>n</i> = 1087). Multilinear regression showed that THS-related knowledge (<i>χ<sup>2</sup></i>[6] = 19.31, <i>p</i> < .01), attitude (<i>χ<sup>2</sup></i>[6] = 13.88, <i>p</i> < .05), and efficacy (<i>χ<sup>2</sup></i>[6] = 13.81, <i>p</i> < .05) significantly increased by the campaign's end, with messages highlighting children's health (<i>r</i> = .110, <i>p</i> < .05), pets (<i>r</i> = .145, <i>p</i> < .01), and dust reservoirs (<i>r</i> = .144, <i>p</i> < .01) as the most persuasive. Path analysis modeling found campaign recall to be associated with changes in knowledge (<i>β </i>= .161, <i>p</i> < .01), which predicated attitude change (<i>β </i>= .614, <i>p</i> < .001) and, in turn, behavior change (<i>β </i>= .149, <i>p</i> < .05). Findings suggest social media campaigns should continue to educate diverse populations about new tobacco risks and that tobacco control advocates should consider integrating educational THS messages.
Wear particles and ions from cemented and uncemented titanium‐based hip prostheses—A histological and chemical analysis of retrieval material (2014)

Wear debris-induced inflammation is considered to be the main cause for periprosthetic osteolysis in total hip replacements (THR). The objective of this retrieval study was to examine the tissue reactions and exposure to metal ions and wear particles in periprosthetic tissues and blood samples from patients with titanium (Ti)-based hip prostheses that were revised due to wear, osteolysis, and/or aseptic loosening. Semiquantitative, histological tissue evaluations in 30 THR-patients revealed numerous wear debris-loaded macrophages, inflammatory cells, and necrosis in both groups. Particle load was highest in tissues adjacent to loosened cemented Ti stems that contained mainly submicron zirconium (Zr) dioxide particles. Particles containing pure Ti and Ti alloy elements were most abundant in tissues near retrieved uncemented cups. Polyethylene particles were also detected, but accounted only for a small portion of the total particle number. The blood concentrations of Ti and Zr were highly elevated in cases with high abrasive wear and osteolysis. Our findings indicate that wear particles of different chemical composition induced similar inflammatory responses, which suggests that particle size and load might be more important than the wear particle composition in periprosthetic inflammation and osteolysis.