gebhart/patrepeval huggingface dataset:
Expression of neurotransmitter receptors and myc protooncogenes in subclones of a human neuroblastoma cell line. (1987)

Phenotypic variability of the human neuroblastoma cell line SK-N-SH was studied with the use of three subclones that interconvert at a slower rate than the parent cell line, i.e., a neuroblast-type subclone (SH-SY5Y), a nonneuronal, strongly substrate adherent subclone (SH-EP), and an intermediate type subclone (SH-IN). Rhodamine-phalloidin staining of actin fibers revealed differences in the cytoskeleton morphology of the three subclones, while the clathrin subunit proteins (heavy and light chains), components of coated vesicles, were invariant. Dramatic differences were observed for the expression of neurotransmitter systems, i.e., the mu and delta opioid receptor, the muscarinic cholinergic receptor and its effect on phosphatidylinositol turnover, and the uptake1 transporter for catecholamines. While these systems were strongly expressed in the parent line and the neuroblast-like clones SH-SY5Y and SH-IN, they were absent or barely detectable in the nonneuronal EP clone. Furthermore, the protooncogenes N- and c-myc were only expressed in the neuroblast containing lines, consistent with their growth characteristics of fully transformed cells. The strong c-myc expression in the absence of c- or N-myc amplification in SK-N-SH, adds a new form of high protooncogene activity in neuroblastoma cell lines. The remarkable differences of neurotransmitter systems and myc expression among the various phenotypes of human neuroblastoma cells should be considered in the therapy of neuroblastoma.
A transition-metal-based method for 1,2-diamination of alkenes. Synthesis of cobalt dinitrosoalkanes from alkenes, nitric oxide, and (.eta.5-cyclopentadienyl)(nitrosyl)cobalt dimer and their reduction to primary vicinal diamines (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA transition-metal-based method for 1,2-diamination of alkenes. Synthesis of cobalt dinitrosoalkanes from alkenes, nitric oxide, and (.eta.5-cyclopentadienyl)(nitrosyl)cobalt dimer and their reduction to primary vicinal diaminesPaul N. Becker and Robert G. BergmanCite this: Organometallics 1983, 2, 7, 787–796Publication Date (Print):July 1, 1983Publication History Published online1 May 2002Published inissue 1 July 1983https://pubs.acs.org/doi/10.1021/om50001a001https://doi.org/10.1021/om50001a001research-articleACS PublicationsRequest reuse permissionsArticle Views674Altmetric-Citations53LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Percolation Scheduling: A Parallel Compilation Technique (1985)

Percolation Scheduling (PS) is a new technique for compiling programs into parallel code. It attempts to overcome problems that limit the effectiveness and applicability of currently available techniques. PS globally rearranges code past basic block boundaries. Its core is a small set of simple, primitive program transformations defined in terms of adjacent nodes in a program graph. These transformations constitute the lowest level in a system of transformations and guidance rules. Higher levels of this hierarchy control and enhance the applicability of the core transformations and enable us to exploit both fine grained and coarse parallelism. Unlike other, more ad hoc approaches, PS is based on rigorous definitions of the computational model and of the core transformations. The correctness and termination of the transformations is proven here. The completeness of the transformations is also discussed. As a result our implementation, which is now underway, can proceed on a sound basis. In particular, PS enjoys greater adaptability and independence between the levels than would be possible otherwise. This paper describes PS in detail. The correctness aspects as well as illustrations of the effectiveness of our techniques are presented. Architectures which may benefit from the use of PS are also discussed.
High Performance Coil Tubing Drilling in Shallow North Slope Heavy Oil (2002)

Abstract Coil tubing drilling (CTD) completed a very successful 4 well pilot project that drilled lengthy horizontal multi-laterals into shallow heavy oil reserves at the Milne Point field on Alaska's North Slope. The CTD sidetracks were drilled with the proper combination of tools that delivered good incremental oil production rate at low cost. This was a new field for the CTD team with challenging directional and completion issues. A coiled tubing electric line drilling BHA and innovative completion techniques were required to achieve objectives. Three dual-lateral wells and one single-lateral well were drilled into thin shallow sands and completed using slotted liner and flow-through whipstocks. Sensors in the modular electric-line CTD bottom-hole-assembly communicated to the surface with an electric line umbilical that provided extremely high-speed directional information, real time downhole weight on bit (DWOB), resistivity data, gamma-ray data, internal pressure and annular pressure data. The electric line also provided power to accurately drive a downhole electric orienter. These features combined with high performance PDM motors achieved very high penetration rates with 3.75 inch PDC bits. Several North Slope CTD drilling records were set during the project. Liner running from high departure parent wellbores proved to be quite challenging but ultimately successful. Learning and performance improvements were made as the project progressed. This paper will review the performance of the CTD BHAs and the completion innovations applied in this project.
Gain saturation properties of a polarization insensitive semiconductor amplifier implemented with tensile and compressive strain quantum wells (1994)

The gain saturation properties of a 1.3 μm polarization insensitive semiconductor amplifier implemented with tensile and compressive strain quantum well active region are experimentally investigated in order to determine how well the amplifier maintains its polarization insensitivity in the saturation regime. The amplifier has unsaturated gain of 12 dB and in the saturation regime the maximum observed gain imbalance between TE and TM gains is 0.9 dB. The measured 3 dB saturation output power is 5 mW.
“中国农村的社会主义高潮”序言 (1956)

摘要 Abstract 作者及机构信息 毛泽东 Authors and contacts 参考文献 [1] 施引文献
Effects of Carbohydrate and Chromium Ingestion during Intermittent High-Intensity Exercise to Fatigue (2000)

The data confirm an ergogenic benefit of ingesting CHO during exercise designed to imitate sports like basketball, soccer, and hockey, but do not support the hypothesis that the addition of Cr would enhance this effect.
Electrophysiological safety of DW-286a, a novel fluoroquinolone antibiotic agent (2005)

Inhibition of the potassium current I(Kr) and QT prolongation has been known to be associated with drug-induced torsades de pointes arrhythmias (TdP) and sudden cardiac death. We investigated the cardiac electrophysiological effects of DW-286a, a new class of fluoroquinolone antibiotics reported to prolong the QT interval. To investigate the electrophysiological safety of DW-286a, we used conventional microelectrode recording techniques in isolated guinea pig papillary muscles, whole-cell patch clamp techniques in human ether-à-go-go related gene (hERG)-transient transfected Chinese hamster ovary cells, and in vivo electrocardiogram (ECG) measurements in Sprague-Dawley (SD) rats by the use of a telemetry system. DW-286a at 300 microM significantly (P<0.01) prolonged action potentials at 50% repolarization (APD50) and 90% repolarization (APD90). For IHERG, the IC50 value was 89.00+/-37.85 microM with a Hill coefficient (nH) of -0.97+/-0.49. However, when DW-286a was orally administered to conscious SD rats at a high dose (1000 mg/kg), no significant effect on ECG in vivo was detected. From a previous study, we know that concentration at 19.8 microM is the antimicrobial end-point of DW-286a. Therefore, our data suggest that in the electrophysiological aspect, it can be thought that the effective concentrations of DW-286a are between 19.8 and 100 microM (concentration in serum).
Effects of annealing on the ageing properties of PMN-0.1PT ceramics doped by transition-metallic ions (2002)

Dielectric ageing behaviors of lead-based relaxor ferroelectric ceramics, which may affect their application in multilayer ceramic capacitors (MLCs), have been an important research problem for many years. In this paper, the effects of annealing on ageing properties of the PMN-0.1PT system, respectively doped with Fe, Co and Ni ions and annealed in different atmospheres (air and N/sub 2/-H/sub 2/) after sintering, were studied. It is found that the annealing atmosphere has a strong influence on the ageing degree of the samples. For the air-annealed samples, the decrease in the dielectric constant was small; whilst for the N/sub 2/H/sub 2/-annealed samples, the decrease was much greater. It is assumed that the different valences of doped ions, resulting from the different annealing atmospheres, are responsible for the different ageing degrees.
Effect of Iron Deficiency Anemia in Pregnancy on Child Mental Development in Rural China (2013)

Prenatal IDA in the third trimester is associated with mental development of the child. However, prenatal supplementation with sufficient iron protects child development even when the woman's IDA was not properly corrected in pregnancy.
THE STAGE-HISTORY (2009)

The first certain mention of Shakespeare's King Richard II is in Palladis Tamia, 1598, where Meres puts it first among the ‘tragedies’; but in his Introduction the editor shows it to have been already seen in 1595. This, then, was the play intended in the official evidence against Essex, compiled in the summer of 1600 in connexion with the trial of John Hayward for writing and Harsnett for publishing the prose history of The First Part of the Life and Raigne of King Henrie IIII: ‘the Erle himself being so often present at the playing thereof, and with great applause giving countenance and lyking to the same’. In August 1601 Queen Elizabeth told William Lambard, referring to the disaffection of Essex, that this tragedy was played forty times in open streets and houses. It was common at that time to see a likeness between King Richard II and Queen Elizabeth (‘I am Richard II. Know ye not that?’ said she to Lambard), and there was obvious resemblance between Bolingbroke's courting of the populace, as described by the King (1. iv), and Essex's. The topical interest of the play led to its being raked up again for the strange proceedings of Saturday, February 7, 1601, the day before Essex dared rebellion. The several accounts establish that on the preceding Thursday and Friday some of Essex's adherents went across the river to the Globe playhouse and there asked the Chamberlain's men to act on the Saturday the play of the deposing and killing of King Richard II, and promised ‘to gete them xls. more then their ordynary to play yt’.
Comparison of Diagnostic Performance of Quantitative Flow Ratio in Patients With Versus Without Diabetes Mellitus (2019)

Quantitative flow ratio (QFR) is a novel technique to calculate fractional flow reserve (FFR), without hyperemia induction or a pressure wire, and has not yet been validated in patients with diabetes mellitus (DM), who are at increased risk of coronary microvascular dysfunction. The purpose of our study was to compare the diagnostic performance of QFR in diabetic and nondiabetic patients. Patients who underwent invasive coronary angiography and subsequent invasive FFR measurement within 6 months were included. QFR was determined in all coronary arteries in which invasive FFR was performed, using a dedicated software package. Diagnostic accuracy and the area under the receiver-operating characteristic curve (AUC) were determined for QFR, using an invasive FFR cut-off value of ≤0.80 as the reference standard. In total, 320 coronary arteries from 66 (25%) diabetic and 193 (75%) nondiabetic patients were analyzed. On a vessel-based analysis, diagnostic accuracy, sensitivity, and specificity showed no significant difference between diabetic and nondiabetic patients: 88% versus 85% (p = 0.47), 71% versus 69% (p = 0.72), and 95% versus 91% (p = 0.24). Moreover, the AUC was not significantly different between patients with and without DM, 0.91 versus 0.93 (p = 0.74). The per-vessel AUC was significantly higher for QFR compared with percent diameter stenosis in both diabetic and nondiabetic patients, 0.91 versus 0.76 (p <0.05) and 0.93 versus 0.77 (p <0.001), respectively. In conclusion, we showed a good diagnostic performance of QFR which was independent of the presence of DM.
Performance analysis and optimization of vehicular spread spectrum radar using multi-beam antenna (2002)

Investigates a vehicular radar system that can measure the distance to, the relative speed of and the direction of arrival (DOA) of the reflected waves from multiple targets or vehicles using the direct-sequence spread spectrum (DS-SS) technique. In particular, we examine the relationship between the number of multiple beams and the error probability of DOA estimation and investigate the relationship between the results of the distance estimation and the DOA estimation. Performance of the system is numerically evaluated using computer simulations in a multipath environment.
Systolic implementation of a general adaptive array processing algorithm (2003)

The authors present a general adaptive array processing algorithm based on the MVDR (minimum variance distortionless response) beamformer for multiple steering vectors and multiple frequencies. They show how they use a sequence of Givens rotations to update the beamformer output, and how they implement the algorithm by means of two linear systolic arrays. The pipelined CORDIC processor is proposed as the processing element to achieve a high data throughput and a straightforward implementation. The problem of complex arithmetic for frequency-domain data is discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Augmented Reality-Based Navigation System for Wrist Arthroscopy: Feasibility (2013)

The augmented reality view represents valuable assistance when surgeons want to position the arthroscope or locate their instruments. It makes the maneuver more intuitive, increases comfort, saves time, and enhances concentration.
Thermoelectric properties of CoSb3 and related alloys (1995)

Seebeck, electrical, and thermal conductivity data are reported on CoSb3, and doped and undoped alloys of Co1−xIrxSb3−yAsy from 20 to 700 K. n-type semiconductors were obtained by doping with Ni, Te, or Pd, and the hole concentration in p-type samples was increased by substitution of Fe, Ru, Os, and Ge. An estimated maximum value for ZT of 0.6 (Z is the figure of merit) was found for a Te-doped (n-type) alloy at 700 K. For p-type alloys, the maximum value of ZT was found to be 0.3 at 550 K. Electrical and thermal transport data also are reported for CoAs3, RhSb3, and IrSb3. Most of the samples investigated were polycrystalline, but a few measurements on CoSb3 single crystals also are discussed.
A lyophilized hemoglobin control prepared from stroma-free hemolysates. (1980)

Abstract We prepared a stable lyophilized hemoglobin control from human erythrocytes by removing stroma with calcium and Ficoll. Addition of polyhydroxy compounds enhanced reconstitution and stability. The lyophilized product was stable during one year of use in a service laboratory. Accelerated aging studies demonstrated the potential of up to two years of stability, with methemoglobin increasing at a projected rate of approximately 6% per year. Reconstituted, the control gave reproducible values for at least five days when refrigerated.
Robots will be of service with muscles, not motors (2005)

Purpose Aims to project how electroactive polymer will replace conventional electromagnetic motor driven solutions for service and industrial robots. Design/methodology/approach Presents the ability of electro active polymer to provide higher power density for robot actuation over conventional approaches. Laboratory tests by DARPA compared electroactive polymer with conventional electromagnetic methodologies as well as shape memory alloy and piezo solutions. Findings Tests by DARPA and SRI International showed significant power density advantages for electroactive polymer artificial muscles (EPAM). Robot prototypes and well as early commercial prototypes developed by Artificial Muscle, Inc. in pumps, valves, and actuators prove superior performance over other actuation solutions. Originality/value Introduces a new low cost, low power consumption, light weight, and silent method for actuation for robots and other motion control devices.
A high performance 90 nm CMOS SAR ADC with hybrid architecture (2010)

A 10-bit 2.5 MS/s SAR A/D converter is presented. In the circuit design, an R-C hybrid architecture D/A converter, pseudo-differential comparison architecture and low power voltage level shifters are utilized. Design challenges and considerations are also discussed. In the layout design, each unit resistor is sided by dummies for good matching performance, and the capacitors are routed with a common-central symmetry method to reduce the nonlin-earity error. This proposed converter is implemented based on 90 nm CMOS logic process. With a 3.3 V analog supply and a 1.0 V digital supply, the differential and integral nonlinearity are measured to be less than 0.36 LSB and 0.69 LSB respectively. With an input frequency of 1.2 MHz at 2.5 MS/s sampling rate, the SFDR and ENOB are measured to be 72.86 dB and 9.43 bits respectively, and the power dissipation is measured to be 6.62 mW including the output drivers. This SAR A/D converter occupies an area of 238 × 214 μm2. The design results of this converter show that it is suitable for multi-supply embedded SoC applications.
Coordinated control and network integration of wave power farms (2012)

Significant progress has been made in the development of wave energy converters (WECs) during recent years, with prototypes and farms of WECs being installed in different parts of the world. With increasing sizes of individual WECs and farms, it becomes necessary to consider the impacts of connecting these to the electricity network and to investigate means by which these impacts may be mitigated. The time-varying and the unpredictable nature of the power generated from wave power farms supplemented by the weak networks to which most of these farms will be connected to, makes the question of integrating a large quantity of wave power to the network more challenging. The work reported here focuses on the fluctuations in the rms-voltage introduced by the connection of wave power farms. Two means to reduce these rms-voltage fluctuations are proposed. In the first method, the physical placement of the WECs within a farm is selected prior to the development of the farm to reduce the fluctuations in the net real power generated. It is shown that spacing the WECs or the line of WECs within a farm at a distance greater than half the peak wavelength and orienting the farm at 90◦ to the dominant wave direction produces a much smoother power output. The appropriateness of the following conclusions has been tested and proven for a wave power farm developed off the Outer Hebrides, using real wave field and network data. The second method uses intelligent reactive power control algorithms, which have already been tested with wind and hydro power systems, to reduce voltage fluctuations. The application of these intelligent control methods to a 6 MW wave power farm connected to a realistic UK distribution network verified that these approaches improve the voltage profile of the distribution network and help the connection of larger farms to the network, without any need for network management or upgrades. Using these control methods ensured the connection of the wave power farm to the network for longer than when the conventional control methods are used, which is economically beneficial for the wave power farm developer. The use of such intelligent voltage - reactive power (volt/VAr) control methods with the wave power farm significantly affects the operation of other onshore voltage control devices found prior to the connection of the farm. Thus, it is essential that the control of the farm and the onshore control devices are coordinated. A voltage estimation method, which uses a one-step-ahead demand predictor, is used to sense the voltage downstream of the substation at the bus where the farm is connected. The estimator uses only measurements made at the substation and historical demand data. The estimation method is applied to identify the operating mode of a wave power farm connected to a generic 11 kV distribution network in the UK from the upstream substation. The developed method introduced an additional level of control and can be used at rural substations to optimise the operation of the network, without any new addition of measuring devices or communication means.
Cancer immunotherapy (2012)

The remarkable specificity of the immune system through antigen recognition has long attracted investigators to the possibility of immune-based therapy for cancer. Previous cancer immunotherapeutics had been restricted to non-specific immunomodulatory agents, such as the cytokines IL-2 or IFN-α. However, the molecular definition of cancer-associated antigens introduced the possibility of specific vaccines and adoptive T cell approaches aiming to target the tumor cells more specifically. The recent introduction of total exome sequencing has enabled the identification of patient tumor-specific epitopes generated through somatic point mutations, raising the possibility of targeting tumor antigens in individual patients which are even more tumor-specific. Transcriptional profiling and immunohistochemistry analyses have revealed a subset of patients with a pre-existing T cell-inflamed tumor microenvironment. This phenotype may be predictive of clinical outcome to immunotherapies and offers the possibility of a predictive biomarker. Further analysis of these tumors has identified a set of defined immune suppressive factors which themselves are being targeted with new immunotherapeutics, already with interesting early phase clinical trial results. Understanding not only the expression of tumor antigens but also the dynamic between a growing tumor and the host immune response is thus generating a rich set of opportunities for the specific immunotherapy of cancer.