gebhart/patrepeval huggingface dataset:
Characteristics of bortezomib‐ and thalidomide‐induced peripheral neuropathy (2008)

Dose-limiting peripheral neuropathy (PN) is frequently reported with the use of thalidomide and bortezomib, novel proteasome inhibitors. While these two agents have significant activity in multiple myeloma (MM), the combination and the associated PN have not been fully examined in untreated patients. The objective of this study was to report the baseline prevalence and occurrence of PN in newly diagnosed MM patients treated with bortezomib and thalidomide. Twenty-seven patients (11 men and 16 women) with previously untreated MM were prospectively monitored for PN. Total neuropathy score reduced (TNSr) was calculated at baseline and after every two cycles of bortezomib treatment. The median cumulative dose of bortezomib was 35.6 mg/m(2) (median 8 cycles) and of thalidomide was 16.8 g. Only three subjects showed mild PN at baseline (whole group median TNSr 0). At the end of treatment, PN developed in 26 patients (median TNSr 8). PN was of mild to moderate severity (TNSr grade 1 = 11, grade 2 = 10, grade 3 = 5, and grade 4 = 0). Nerve conduction studies showed axonal physiology in all except three subjects in whom demyelinating physiology was noted. The median TNSr was 17 in the demyelinating group and 9 in the axonal group. There was no significant correlation of TNSr with cumulative bortezomib or thalidomide dose. At follow-up, 80% of patients had become asymptomatic after discontinuation of the chemotherapy. We conclude that bortezomib and thalidomide combination chemotherapy induces a reversible length-dependent sensory>motor, predominantly axonal, large-fiber>small-fiber polyneuropathy. In a subset, a more severe demyelinating polyneuropathy may develop.
Mycobacterial Codon Optimization Enhances Antigen Expression and Virus-Specific Immune Responses in Recombinant<i>Mycobacterium bovis</i>Bacille Calmette-Guerin Expressing Human Immunodeficiency Virus Type 1 Gag (2005)

Although its potential for vaccine development is already known, the introduction of recombinant human immunodeficiency virus (HIV) genes to Mycobacterium bovis bacille Calmette-Guérin (BCG) has thus far elicited only limited responses. In order to improve the expression levels, we optimized the codon usage of the HIV type 1 (HIV-1) p24 antigen gene of gag (p24 gag) and established a codon-optimized recombinant BCG (rBCG)-p24 Gag which expressed a 40-fold-higher level of p24 Gag than did that of nonoptimized rBCG-p24 Gag. Inoculation of mice with the codon-optimized rBCG-p24 Gag elicited effective immunity, as evidenced by virus-specific lymphocyte proliferation, gamma interferon ELISPOT cell induction, and antibody production. In contrast, inoculation of animals with the nonoptimized rBCG-p24 Gag induced only low levels of immune responses. Furthermore, a dose as small as 0.01 mg of the codon-optimized rBCG per animal proved capable of eliciting immune responses, suggesting that even low doses of a codon-optimized rBCG-based vaccine could effectively elicit HIV-1-specific immune responses.
Hybrid hydrogen PEM fuel cell and batteries without DC–DC converter (2013)

Concerns about greenhouse gases as well as the price and security of oil supply have acted as a spur to sustainable automobile development. The hydrogen fuel cells electric vehicle (HFCEV) is generally recognised by leading automobile manufacturers and scientists as one of the optimum technologies for long-term future low carbon vehicle. In a typical HFCEV power train, a DC -DC converter is required to balance the voltage difference between the fuel cells (FCs) stack and batteries. However, research shows that a considerable amount of energy generated by the hydrogen FCs stack is deplete during this conversion process as heat. This experiment aims to improve the power train efficiency by eliminating the DC -DC converter by finding the best combination of FC stack and batteries, matching the size and capacity of the electrical components.
Investigating the personal experiences and self-efficacy of Western Australian primary pre-service teachers in the visual arts (2014)

The Visual Arts are essential to interpreting culture and introduction to the Visual Arts often occurs within primary school. A mixed methods study was undertaken at a Western Australian university across the Arts subjects: dance, drama, media Arts, music and Visual Arts. This paper reports the quantitative findings of the Visual Arts section of the investigation, examining students’ prior Visual Arts experiences and their self-efficacy to deliver the Visual Arts on graduating their degree. The research underscores the importance of positive Visual Arts experiences to build self-efficacy and intrinsic motivation among pre-service primary teachers.
Entity Linking for Tweets (2013)

We study the task of entity linking for tweets, which tries to associate each mention in a tweet with a knowledge base entry. Two main challenges of this task are the dearth of information in a single tweet and the rich entity mention variations. To address these challenges, we propose a collective inference method that simultaneously resolves a set of mentions. Particularly, our model integrates three kinds of similarities, i.e., mention-entry similarity, entry-entry similarity, and mention-mention similarity, to enrich the context for entity linking, and to address irregular mentions that are not covered by the entity-variation dictionary. We evaluate our method on a publicly available data set and demonstrate the effectiveness of our method. 1
Corn and Soybean Yield Response to Crop Residue Management Under No‐Tillage Production Systems<sup>1</sup> (1986)

Abstract Crop residues (stover) have many potential uses by society: food, feed, shelter, fuel, and soil amendment. Use of residues for purposes other than as a soil amendment may have serious negative consequences on crop productivity. This study was conducted to investigate the yield response of continuous corn ( Zea mays L.) and continuous soybean [ Glycine max (L.) Merr.] to removal or addition of crop residues under no‐tillage management. The study was conducted near Lincoln, NE, on a Crete‐Butler silty clay loam (fine, montmorillonitic, mesic Pachic Arguistoll‐Abruptic Argiaquoll) with 1 to 2% slope. Crop residue was collected and weighed immediately after harvest in autumn. Quantity of residue to be returned to each treatment (0, 50, 100, or 150% of that produced) was calculated and uniformly spread over the plot area (12.2 by 12.2 m) by hand. Corn and soybean were planted into the established residue levels with no tillage the following spring. Data were collected on soil water, soil temperature, and grain and residue yield. A positive linear response was found between grain and stover yield and amount of residue applied to the soil surface. Each Mg ha −1 of residue removed resulted in about a 0.10 Mg ha −1 reduction in grain yield and a 0.30 Mg ha −1 reduction in residue yield. Quantity of applied residue accounted for 81 and 84% of the variation in grain yield of corn and soybean, respectively, and 88 and 92% of the variation in residue yield. Amounts of stored soil water at planting were closely associated with quantity of residue applied the previous year. Differences in total available water (soil storage at planting plus rainfall) accounted for approximately 70% of the yield variation associated with the residue treatments. Soil temperature (50‐mm depth) and total available water accounted for nearly the same amount of variation in yield (80 to 90%) as quantity of residue, emphasizing the importance of these factors in evaluating response of crops to residue‐management practices. Residue removal reduced grain and residue yields by amounts equal to 10 and 30%, respectively, of the quantity of residue removed. Residue effects on crop yield were induced mainly through changes in soil water and soil temperature.
Peroxiredoxin‐I is an autoimmunogenic tumor antigen in non‐small cell lung cancer (2005)

In eukaryotic cells, peroxiredoxins are both antioxidants and regulators of H(2)O(2)-mediated signaling. We previously found that peroxiredoxin-I (Prx-I) was overexpressed in non-small cell lung cancer (NSCLC) tissue. Since overexpressed protein can induce a humoral immune response, we examined whether serum from NSCLC patients exhibited immunoreactivity against Prx-I using Western blotting. We found that 25 (47%) of 53 NSCLC patients tested had autoantibodies against Prx-I in their sera, whereas such activity was detected in 4 (8%) sera from 50 healthy subjects. Prx-I itself was detected in the sera from 18 (34%) of 53 NSCLC patients but in only 1 (2%) serum from 50 controls. Moreover, 17% of NSCLC sera were positive to both Prx-I antibody and antigen but none in control sera. The data indicate both Prx-I autoantibody and circulating antigen are potential biomarkers for use in serological diagnosis of NSCLC. Interestingly enough, we found that Prx-I was secreted by lung adenocarcinoma cells (A549) but not by non-cancer lung cells (BEAS 2B) or breast cancer cells (MCF7). This cell culture study suggests the possibility of Prx-I secretion from NSCLC tumor tissues.
The Gene Encoding SMR1, a Precursor-Like Polypeptide of the Male Rat Submaxillary Gland, Has the Same Organization as the Preprothyrotropin-Releasing Hormone Gene (1990)

SMR1 is a precursor-like polypeptide of the submaxillary glands of rats. Sequence analysis predicts that it could be processed by maturation enzymes to release a small peptide resembling the thyrotropin-releasing hormone. The SMR1 gene was isolated from a rat genomic library and sequenced. The SMR1 gene spans 4.7 kb and consists of three exons. The two introns occur a few nucleotides before the initiation codon in the 5' untranslated region, and a few nucleotides before the first predicted processing site, respectively. Such a structure is reminiscent of that of the preprothyrotropin-releasing hormone gene. The site of transcriptional initiation of the SMR1 gene was determined and 1.4 kb of 5'-flanking sequence was sequenced. The sequence analysis revealed the presence of alternating purine-pyrimidine tracts and of purine-rich sequences. In addition, some sequences which could be involved in the regulation of SMR1 gene expression were identified.
Hydrogenation of Dinitriles in Liquid Methylamine (1946)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHydrogenation of Dinitriles in Liquid MethylamineB. S. Biggs and W. S. BishopCite this: Ind. Eng. Chem. 1946, 38, 10, 1084–1086Publication Date (Print):October 1, 1946Publication History Published online1 May 2002Published inissue 1 October 1946https://pubs.acs.org/doi/10.1021/ie50442a031https://doi.org/10.1021/ie50442a031research-articleACS PublicationsRequest reuse permissionsArticle Views52Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
An output power stabilized erbium-doped fiber amplifier with automatic gain control (1997)

Based on the cross-saturation between two different-wavelength optical signals in an erbium-doped fiber amplifier (EDFA), we have developed an output power stabilized EDFA system with automatic gain control. The developed system shows 18.5-dB dynamic range of the output power limitation with the ability to set the output power level arbitrarily. When a temporally varying optical signal is input, the system works as a fluctuation remover for the input signal modulated at low frequency up to 1 kHz and does not have any deteriorative effect on high-frequency modulated optical signals. The degree of modulation in the fluctuated optical signal can be reduced down to as low as 0.003.
The Growing Synthetic Utility of the Weinreb Amide (2008)

N-Methoxy-N-methylamide, popularly addressed as the Weinreb amide, has surfaced as an amide with a difference. This amide has served as an excellent acylating agent for organolithium or organomagnesium reagents and as a robust equivalent for an aldehyde group. These two aspects have been exploited exhaustively in various synthetic endeavors. This review presents the growing synthetic utility of the Weinreb amide not only in academic circles, but also its popular use on kilogram scale by various pharmaceutical industries across the globe.
Molecular modeling study of structural requirements for the oligopeptide transporter (1996)

The intestinal oligopeptide transporter (OPT) mediates the absorption of di-/tripeptides, beta-lactam antibiotics, angiotensin converting enzyme (ACE) inhibitors and renin inhibitors. This suggests that the targeting of molecules to this transporter could result in orally-absorbed drugs. Results from a recent study with renal brush border membrane vesicles (BBMV) suggested that an alpha-NH2 group is required for interaction with the renal OPT. In general, structural requirements for interaction with the renal and intestinal OPT are similar. However, these recent findings do not agree with earlier studies, which showed that an alpha-NH2 group is not essential for interaction with the intestinal OPT. Thus, it appears that the renal and intestinal OPT may differ in their recognition of compounds containing an alpha-NH2 group. In this study, molecular modeling was used to determine the tridimensional structures of various cephalosporins for which Ki values had been determined using renal BBMV. All cephalosporins which interact with the OPT have two, energetically equivalent, conformations. Most compounds which do not interact with the OPT cannot adopt the two conformations. A key factor which influences the conformation seems to be the substituent group at the alpha position; an electron drawing group at that position alters the common conformations. For the OPT substrates, the distances between the -NH2 and -COOH groups are comparable to those of the tripeptide, GlyGlyGly; and the distances between -NH2 and carbonyl group in the beta-lactam ring are close to the distance between N-terminal and C-terminal in the dipeptide, GlyGly. The corresponding distances in cephamycin C (in which a -NH2 group is located in a different position) and the tetrapeptide, GlyGlyGlyGly, are longer than those in alpha-NH2 cephalosporins and GlyGlyGly. Cephamycin C and the tetrapeptide have low affinity for the renal OPT, suggesting that the distances between functional groups are critical for affinity. The alpha-NH2 group had no effect on the conformations of the molecules. We concluded that the alpha-NH2 group may interact directly with the renal oligopeptide transporter. Whether this is unique to the renal transporter or could be applied to the intestinal transporter will require further investigation.
A role for ion channels in glioma cell invasion. (2006)

Many cells, including neuronal and glial progenitor cells, stem cells and microglial cells, have the capacity to move through the extracellular spaces of the developing and mature brain. This is particularly pronounced in astrocyte-derived tumors, gliomas, which diffusely infiltrate the normal brain. Although a significant body of literature exists regarding signals that are involved in the guidance of cells and their processes, little attention has been paid to cell-shape and cell-volume changes of migratory cells. However, extracellular spaces in the brain are very narrow and represent a major obstacle that requires cells to dynamically regulate their volume. Recent studies in glioma cells show that this involves the secretion of Cl(-) and K(+) with water. Pharmacological inhibition of Cl(-) channels impairs their ability to migrate and limits tumor progression in experimental tumor models. One Cl(-)-channel inhibitor, chlorotoxin, is currently in Phase II clinical trials to treat malignant glioma. This article reviews our current knowledge of cell-volume changes and the role of ion channels during the migration of glioma cells. It also discusses evidence that supports the importance of channel-mediated cell-volume changes in the migration of immature neurons and progenitor cells during development. New unpublished data is presented, which demonstrates that Cl(-) and K(+) channels involved in cell shrinkage localize to lipid-raft domains on the invadipodia of glioma cells and that their presence might be regulated by trafficking of these proteins in and out of lipid rafts.
Processing with kW fibre lasers: advantages and limits (2008)

Up-to-date fibre lasers produce multi-kw radiation with an excellent beam quality. Compared to CO<sub>2</sub>-lasers, fibre lasers have relatively low operational costs and offer a very high flexibility in production due to the beam delivery with process fibres. As a consequence, fibre lasers have attracted more and more attention. On the other hand, their use in industrial applications especially in the automotive industry is still limited to a certain extent and fibre lasers haven't replaced all other laser sources till now as it could be expected. In laser cutting, the small kerf width produced by fibre lasers should be advantageous since the heated volume is smaller compared to CO<sub>2</sub>-lasers. In fact, cutting velocities are usually much higher which is also caused by the higher absorption coefficient of most metals at the wavelength emitted by fibre lasers. Nevertheless, cutting with fibre lasers of some metals - e.g. stainless steels - is restricted to a small thicknesses of approx. 5mm. The reason for this is that the surface roughness of the edges increases dramatically with the thickness of the work piece. Applications of fibre lasers include e.g. remote welding or even remote cutting of a large variety of materials with usually excellent results. Due to the excellent beam quality the aspect ratio of the weld seam in relation to the penetration depth is quite good. In the case of thin sheet metal welding such a small beam waist is beneficial - but with thicker sheet metals it is very often disadvantageous since the preparation of samples is more complicated, costs increase and requirements on clamping devices rise. In this paper, advantages and disadvantages of fibre lasers are discussed briefly. Applications of a 1.5 kW fibre laser are presented and compared to classical laser systems.
The Choice of Compressor Effects the Aerosol Parameters and the Delivery of Tobramycin from a Single Model Nebulizer (2000)

Recent U.S. Phase III trials of the aerosolized delivery of tobramycin to cystic fibrosis (CF) patients demonstrated a significant improvement in pulmonary function and in sputum bacterial density. These trials used the Pari LC Plus nebulizer and DeVilbiss Pulmo-Aide compressor. This compressor is not generally available in Europe, and its power requirements do not match the European power supply. Thus alternate compressors were evaluated, using the LC Plus nebulizer, in preparation for European clinical trials. Aerosol particle size distribution, nebulization time (min), and the respirable dose of tobramycin (mg within 1-5 mu) were obtained for seven compressor models. The respirable quantity delivered by each of the European compressors (240 Volts, 50 Hz) was compared to the LC Plus and PulmoAide compressor (120 Volts, at 60 Hz). The U.S. system delivered 71.4 mg of the 300 mg instilled dose within the respirable range; using the European compressors, between 63.0 and 74.8 mg was delivered. With a 97% confidence that the delivered tobramycin was within 20% of the standard, we conclude that the SystAm 23ST, MedicAid CR50 and CR60, Pari Master and the Pari Boy compressors are equivalent to the U.S. standard; the Hercules and the SystAm 26ST compressors were not statistically equivalent to the standard. Using the LC Plus nebulizer, five European compressors delivered doses of TOBI that are similar to the doses delivered by the DeVilbiss PulmoAide compressors, and thus may be expected to produce clinical results similar to those of the U.S. trials.
Verapamil Increases Rhodamine 123 Laser Phototherapy of Drug-Resistant Human Sarcoma Cells (1994)

It has been reported previously that rhodamine 123 (Rh123) can sensitize carcinomas and several other types of human tumor cells for inactivation by laser illumination. However, sarcoma cells often were found to be resistant to Rh123. In the present study, we observed that verapamil (Vp) reverses this drug resistance in human HT1080 fibrosarcoma cells and allows Rh123 laser phototherapy. Intracellular Rh123 levels were measured by spectrophotometric absorbance at 400–600 nm after extraction of dye from cells with butanol. HT1080 cells incubated with 10 μg/ml Rh123 and 0–1 μM Vp had less than 50 ng Rh123/ml uptake with no increase over time up to 8 hr. However at 5, 10, and 100 μM Vp retention of Rh123 increased by 8 hr to peak levels of 200, 290, and 480 ng, respectively. Drug-sensitive TE671 fibrosarcoma cells treated in the same manner had linear Rh123 uptake in the absence of Vp. Argon laser and Rh123 treatment of Vp-sensitized HT1080 fibrosarcoma cells reduced tumor cell proliferation as measured by [3H]thymidine uptake over 80% compared to no effect on these cells in the absence of Vp. Western blotting with antibody to the multiple drug-resistance P-glycoprotein confirmed strong over expression by HT1080 compared to TE671 fibrosarcoma cells. These results show Vp increases Rh123 and laser sensitivity by blocking the P-glycoprotein efflux pump in the human sarcoma cells and suggests Rh123 laser phototherapy may be possible in patients with multiple drug-resistant tumors.
A Physical-Layer Rateless Code for Wireless Channels (2013)

In this paper, we propose a physical-layer rateless code for wireless channels. A novel rateless encoding scheme is developed to overcome the high error floor problem caused by the low-density generator matrix (LDGM)-like encoding scheme in conventional rateless codes. This is achieved by providing each symbol with approximately equal protection in the encoding process. An extrinsic information transfer (EXIT) chart based optimization approach is proposed to obtain a robust check node degree distribution, which can achieve near-capacity performances for a wide range of signal to noise ratios (SNR). Simulation results show that, under the same channel conditions and transmission overheads, the bit-error-rate (BER) performance of the proposed scheme considerably outperforms the existing rateless codes in additive white Gaussian noise (AWGN) channels, particularly at low BER regions.
Experimental Evidence of Self-Limited Growth of Nanocrystals in Glass (2009)

Growth of nanocrystals precipitated in glasses with specific compositions can be effectively limited by diffusion barriers forming around crystallites. For the first time, we do experimentally prove this concept of self-limited growth on the nanoscale for a SiO(2)/Al(2)O(3)/Na(2)O/K(2)O/BaF(2) glass in which BaF(2) nanocrystals are formed. As shown by advanced analytical transmission electron microscopy techniques, the growth of these BaF(2) crystals, having great potential for photonic applications, is inherently limited by the formation of a ca. 1 nm wide SiO(2) shell.