gebhart/patrepeval huggingface dataset:
Three-year Follow up of GMCSF/bi-shRNAfurin DNA-transfected Autologous Tumor Immunotherapy (Vigil) in Metastatic Advanced Ewing's Sarcoma (2016)

Ewing's sarcoma is a devastating rare pediatric cancer of the bone. Intense chemotherapy temporarily controls disease in most patients at presentation but has limited effect in patients with progressive or recurrent disease. We previously described preliminary results of a novel immunotherapy, FANG (Vigil) vaccine, in which 12 advanced stage Ewing's patients were safely treated and went on to achieve a predicted immune response (IFNγ ELISPOT). We describe follow-up through year 3 of a prospective, nonrandomized study comparing an expanded group of Vigil-treated advanced disease Ewing's sarcoma patients (n = 16) with a contemporaneous group of Ewing's sarcoma patients (n = 14) not treated with Vigil. Long-term follow-up results show a survival benefit without evidence of significant toxicity (no ≥ grade 3) to Vigil when administered once monthly by intradermal injection (1 × 10e(6) cells/injection to 1 × 10e(7) cells/injection). Specifically, we report a 1-year actual survival of 73% for Vigil-treated patients compared to 23% in those not treated with Vigil. In addition, there was a 17.2-month difference in overall survival (OS; Kaplan-Meier) between the Vigil (median OS 731 days) and no Vigil patient groups (median OS 207 days). In conclusion, these results supply the rational for further testing of Vigil in advanced stage Ewing's sarcoma.
Thermal Protective Coatings (1976)

An exploratory research and development program was performed for the purpose of providing an effective thermal barrier for aircraft and pilot protection in the event of an aircraft fire. The primary objective of the program was Task I, which consisted of examining the effectiveness of expanding naturally occurring fillers (Perlite and Vermiculite) when used in combination with organic and inorganic matrix coating systems. Both filler systems expand and increase in volume up to 20 times when exposed to heat and liberate no toxic gases. Thin coatings of these filler systems combined with various organic intumescent paints and inorganic matrix systems were developed and thermally evaluated. Test specimens were exposed to a frontface thermal flux environment of 13.5 BTU/ft sq ft--sec (15.3 joules/sq cm--sec) within the door opening of an electric furnace while the aluminum substrate specimen backface temperature rise with respect to time of exposure was continuously monitored and autographically recorded. The most effective thermal coating developed was composed of an intumescent paint, No. 3 grade Vermiculite and 0.5 inch (1.27 cm) length graphite fiber in the respective ratios of 65.8 percent, 33.9 percent, and 0.03 percent by weight. This coating when applied at a thickness of 0.060 inch (0.15 cm) to an aluminum substrate and tested as described will insulate the substrate for a period of 6.8 minutes before a temperature of 500 F (260 C) is reached and for a period of 17.4 minutes before a temperature of 800 F (427 C) is reached. Task II consisted of thermally characterizing 60 government furnished ceramic felts by exposing them to a thermal flux of 15 BTU/f sq ft.--sec.
Intravenous growth hormone: growth responses to patterned infusions in hypophysectomized rats (1985)

Young hypophysectomized rats were maintained with chronic indwelling i.v. cannulae attached via swivels to a multichannel pumping system programmed to deliver GH in a continuous or pulsatile pattern for several days. Continuous i.v. infusions of human GH for 5 days produced dose-dependent increases in body weight and tail length, without increasing food intake. A comparison of GH infusions by the s.c. or i.v. route showed that the direct i.v. route was threefold more effective. Pulsatile i.v. infusions of human or bovine GH at two doses (12 or 36 mu./day, eight pulses/day, 5-min duration, every 3 h) produced greater increases in body weight than continuous i.v. infusions of GH at the same daily dose. Continuous infusions of bovine GH produced a lower growth rate in the second of two consecutive 5-day treatment periods, whereas the responses to pulsatile GH did not diminish with time. Both body weight gain and long-bone growth were affected by the frequency of GH pulses; nine pulses per day were more effective than three pulses per day which in turn produced larger growth responses than one pulse per day. Keeping GH pulse frequency constant and varying pulse duration (4, 16 or 64 min) did not affect growth rates. In conclusion, long-term pulsatile i.v. infusions of GH mimic the endogenous secretory pattern, and are most effective when given at the physiologically appropriate pulse frequency.
Transmission of Helicobacter pylori Infection Studies in Families of Healthy Individuals (1991)

Helicobacter pylori is accepted as the commonest cause of type-B gastritis. Detailed information about the mode of transmission remains scanty. We investigated the frequency of H. pylori infection within families, defined as consisting of a husband and wife with at least one biologic child, all living in the same household. Inclusion criteria required that both the parents and the children had been born in the United States, had used no antibiotic or bismuth for the previous 2 months, had no recent major illness or surgical operation, and had no symptoms referable to the upper gastrointestinal tract. H. pylori infection was identified with a 13C-urea breath test and an enzyme-linked immunosorbent assay for anti-H. pylori IgG. Forty-one families (151 healthy individuals) were enrolled. Before the results of the H. pylori tests were known, one parent was selected as the index subject. H. pylori infection clustered; that is, 68% of spouses of H. pylori-infected index subjects were also H. pylori-infected, compared with 9% of spouses of H. pylori-negative index subjects (p < 0.0001). The children of infected index parents were also more likely to be infected than children of uninfected index parents—40% versus 3%, respectively (p < 0.0001)—and the results in the children were independent of whether the father or the mother was the index subject. Clustering of H. pylori infection within families suggests person-to-person transmission or common source exposure. The high frequency of H. pylori infection in spouses suggests that genetic factors are less important than living conditions for transmission of H. pylori infection.
Effect of mutational alteration of Asn-128 in the putative GTP-binding domain of tetracycline resistance determinant Tet(O) from Campylobacter jejuni (1993)

The deduced amino acid sequence of Campylobacter jejuni Tet(O), cloned in Escherichia coli, has shown that it contains the five highly conserved sequences of the GTP-binding domain found in other GTPases. Asn-128 belongs to the G4 motif of such a domain and is involved in hydrogen bonding with the guanine ring of the nucleotide. Substitution of Asn-128 by 11 other amino acids resulted in a decrease in tetracycline resistance, indicating that tetracycline resistance conferred by Tet(O) is related to GTP binding. The effect of the mutations on the GTP-binding domain is discussed with the EF-Tu-GDP complex as a model.
Light-induced reversible pH change (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLight-induced reversible pH changeMasahiro IrieCite this: J. Am. Chem. Soc. 1983, 105, 7, 2078–2079Publication Date (Print):April 1, 1983Publication History Published online1 May 2002Published inissue 1 April 1983https://pubs.acs.org/doi/10.1021/ja00345a075https://doi.org/10.1021/ja00345a075research-articleACS PublicationsRequest reuse permissionsArticle Views2281Altmetric-Citations153LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Potential Involvement of Extracellular Signal-regulated Kinase 1 and 2 in Encystation of a Primitive Eukaryote, Giardia lamblia (2003)

Mitogen-activated protein kinase (MAPK) pathways are major signaling systems by which eukaryotic cells convert environmental cues to intracellular events such as proliferation and differentiation. We have identified Giardia lamblia homologues of two members of the MAPK family ERK1 and ERK2. Functional characterization of giardial ERK1 and ERK2 revealed that both kinases were expressed in trophozoites and encysting cells as 44- and 41-kDa polypeptides, respectively, and were catalytically active. Analysis of the kinetic parameters of the recombinant proteins showed that ERK2 is approximately 5 times more efficient than ERK1 in phosphorylating myelin basic protein as a substrate, although the phosphorylating efficiency of the native ERK1 and ERK2 appeared to be the same. Immunofluorescence analysis of the subcellular localization of ERK1 and ERK2 in trophozoites showed ERK1 staining mostly in the median body and in the outer edges of the adhesive disc and ERK2 staining in the nuclei and in the caudal flagella. Our study also showed a noticeable change in the subcellular distribution of ERK2 during encystation, which became more punctate and mostly cytoplasmic, but no significant change in the ERK1 localization at any time during encystation. Interestingly, both ERK1 and ERK2 enzymes exhibited a significantly reduced kinase activity during encystation reaching a minimum at 24 h, except for an initial approximately 2.5-fold increase in the ERK1 activity at 2 h, which resumed back to the normal levels at 48 h despite no apparent change in the expression level of either one of these kinases in encysting cells. A reduced concentration of the phosphorylated ERK1 and ERK2 was also evident in these cells at 24 h. Our study suggests a functional distinction between ERK1 and ERK2 and that these kinases may play a critical role in trophozoite differentiation into cysts.
Compensation of Chromatic Dispersion and Nonlinearity Using Simplified Digital Backpropagation (2008)

We study digital backpropagation for compensating linear and nonlinear impairments in single-mode fiber. We reduce computational complexity by increasing the spatial step size. We evaluate the effects of sampling rate and dispersion map on performance.
Two-Dimensional Video Disdrometer: A Description (2002)

This paper describes the design and operation of a two-dimensional video disdrometer (2DVD) for in situ measurements of precipitation drop size distribution. The instrument records orthogonal image projections of raindrops as they cross its sensing area, and can provide a wealth of information, including velocity and shape, of individual raindrops. The 2DVD is a sensitive optical instrument that is exposed to rain, high humidity, and possibly high temperatures. These and other issues such as calibration procedures impact its performance. Under low-wind conditions, the instrument can provide accurate and detailed information on drop size, terminal velocity, and drop shape in a field setting, and the instrument's advantages far outweigh its disadvantages.
Attitude controls for VTOL aircraft Patent (1969)

Development of attitude control system for vertical takeoff aircraft using reaction nozzles displaced from various axes of aircraft
Detection of symmetry of Boolean functions represented by ROBDDs (1993)

Addresses the problem of the detection of symmetries of Boolean functions. To know these symmetries may be important in several stages of logic design, e.g. in logic optimization, in logic synthesis, and in technology mapping. Reduced ordered binary decision diagrams (ROBDDs) play an important role in these tools. Using this representation form for Boolean functions there is a simple symmetry test by checking if certain cofactor functions are equivalent, i.e. if their ROBDD representations are the same. Unfortunately, this procedure may be very time and storage consuming because of the necessary cofactor computations. The approach presented in this paper uses preprocessing methods to find as many asymmetric pairs of variables as possible to avoid cofactor computations at the end. For that, special properties of the ROBDD structure as well as properties of Boolean functions are used. Experimental results on a large number of benchmarks show that this is a very efficient approach.
Pharmacological properties and derivatives of shikonin—A review in recent years (2019)

Shikonin is the major bioactive component extracted from the roots of Lithospermum erythrorhizon which is also known as "Zicao" in Traditional Chinese Medicine (TCM). Recent studies have shown that shikonin demonstrates various bioactivities related to the treatment of cancer, inflammation, and wound healing. This review aimed to provide an updated summary of recent studies on shikonin. Firstly, many studies have demonstrated that shikonin exerts strong anticancer effects on various types of cancer by inhibiting cell proliferation and migration, inducing apoptosis, autophagy, and necroptosis. Shikonin also triggers Reactive Oxygen Species (ROS) generation, suppressing exosome release, and activate anti-tumor immunity in multiple molecular mechanisms. Examples of these effects include modulating the PI3K/AKT/mTOR and MAPKs signaling; inhibiting the activation of TrxR1, PKM2, RIP1/3, Src, and FAK; and regulating the expression of ERP57, MMPs, ATF2, C-MYC, miR-128, and GRP78 (Bip). Next, the anti-inflammatory and wound-healing properties of shikonin were also reviewed. Furthermore, several studies focusing on shikonin derivatives were reviewed, and these showed that, with modification to the naphthazarin ring or side chain, some shikonin derivatives display stronger anticancer activity and lower toxicity than shikonin itself. Our findings suggest that shikonin and its derivatives could serve as potential novel drug for the treatment of cancer and inflammation.
Prácticas no laborales en empresas: análisis crítico del RD 1543/2011, de 31 de octubre (2012)

El Real Decreto 1543/2011, sobre practicas no laborales en empresas, es una norma de dificil legalidad: carece del preceptivo dictamen del Consejo de Estado, incurre en clara extralimitacion ultra vires y colisiona con la regulacion que el Estatuto de los Trabajadores efectua de los contratos formativos. De ahi �segun el autor- los posibles problemas de las empresas que hagan uso de tales «practicas no laborales»
Impregnation of Rice Straw Hardboards (1984)

On a impregne des panneaux de fibres durs par de la cire de paraffine emulsifiee, de la colophane, de l'huile de lin bouillie et des acides gras insatures. On etudie les proprietes physiques et mecaniques des panneaux traites. La cire de paraffine et la colophane degradent les proprietes, l'huile siccative et l'acide oleique les ameliorent
Alivio de la pobreza y fondos de inversion social : la experiencia Latinoamericana (1995)

Most Social Investment Funds (SIFs) in Latin America were created to alleviate the impact on the poor of the reduction in income and employment caused by the debt crisis and the structural adjustment measures taken to lay the basis for renewed growth. The traditional social sector ministries were ill prepared for this task. Many SIFs have been transformed into permanent or semi-permanent entities to finance infrastructure and social service projects targeted to reach the very poor. Furthermore, most SIFs in Latin America have been characterized as effective financial intermediaries. The main attribute of SIFs is the high degree of autonomy achieved through choice of private sector managers with no salary limitation, and exemption from Government's annual budget cycle as well as from bureaucratic procurement and disbursement procedures. A computerized information system, frequent audits and a high degree of beneficiary participation and transparency have also ensured rapid and efficient execution of projects. This discussion paper reviews the experience of twelve SIFs created in Latin America since 1986. It attempts to identify best practices and lessons learned and to analyze policy and operational issues related to the use of SIFs as financial intermediaries for small-scale, multisectoral investments aimed at alleviating poverty among targeted population groups. It also attempts to analyze the future perspectives of SIFs.
Overview (2014)

Explains that the book explores at the country, sectoral, and product levels the binding constraints facing light manufacturing in Vietnam; how firms have coped with these constraints; and which practical policy reforms would help firms overcome the constraints and jump-start industry to facilitate the transformation of Vietnam into a modern economy. Five light manufacturing industries form the core of the Vietnamese industrial sector: processed foods and beverages (agribusiness), leather, wood processing and wood products, metal products, and apparel. Because it is the world’s most competitive country in light manufacturing and a fierce competitor in many domestic markets throughout the world, China provides an appropriate benchmark for an in-depth study of the cost structure of production in Vietnam. Upon emerging in global markets, China had to adapt to compete in manufactured goods that were dominated by others. China successfully moved from cheap, labor-intensive goods to higher-value added goods, and shared many of the investment climate constraints currently prevailing in Vietnam.
Integrated ultrasound and magnetic resonance imaging for simultaneous temperature and cavitation monitoring during focused ultrasound therapies (2013)

The authors have demonstrated the feasibility of integrating an ultrasound imaging array into an MRgFUS system to simultaneously map localized cavitation activity and temperature. The authors anticipate that this integrated approach can be utilized to develop controllers for cavitation-enhanced ablation and facilitate the optimization and development of this and other ultrasound therapies. The integrated system may also provide a useful tool to study the bioeffects of acoustic cavitation.
Brain-machine interface control of a robot arm using actor-critic rainforcement learning (2012)

Here we demonstrate how a marmoset monkey can use a reinforcement learning (RL) Brain-Machine Interface (BMI) to effectively control the movements of a robot arm for a reaching task. In this work, an actor-critic RL algorithm used neural ensemble activity in the monkey's motor cortext to control the robot movements during a two-target decision task. This novel approach to decoding offers unique advantages for BMI control applications. Compared to supervised learning decoding methods, the actor-critic RL algorithm does not require an explicit set of training data to create a static control model, but rather it incrementally adapts the model parameters according to its current performance, in this case requiring only a very basic feedback signal. We show how this algorithm achieved high performance when mapping the monkey's neural states (94%) to robot actions, and only needed to experience a few trials before obtaining accurate real-time control of the robot arm. Since RL methods responsively adapt and adjust their parameters, they can provide a method to create BMIs that are robust against perturbations caused by changes in either the neural input space or the output actions they generate under different task requirements or goals.
Characterization of Sodiated Lipids by Electrospray Ionization‐Quadrupole Ion Trap Tandem Mass Spectrometry (2002)

Abstract Collisionally activated dissociation (CAD) of glycerophosphoglycerol, glycerophosphocholine, glycerophosphoethanolamine, and glycerophosphoserine species was examined using quadrupole ion trap mass spectrometry (QITMS). Since the spectral patterns obtained by QITMS may differ from those obtained using sector or quadrupole mass spectrometry, methods employed in the structure analysis of phospholipids on a sector or quadrupole mass spectrometer are not necessarily useful on an ion trap mass spectrometer. CAD (or MS/MS) of sodiated phospholipids was proposed to structurally analyze phospholipids. The CAD spectra of such ions obtained by QITMS revealed informative ions. Product ions that corresponded to the loss of polar heads identified the lipid classes. Product ions formed by the loss of fatty acyl substituents from sn‐1 and sn‐2 positions were also observed. A preferential loss of the sn‐1 fatty acyl group over the loss of the sn‐2 fatty acyl group was observed among the phospholipid standards examined. This facilitated the determination of the identities and positions of fatty acyl substituents.
Contact with the community (2010)

Subtitle: Three European ports' have implemented different approaches to fostering a beneficial two-way relationship with their local communities. Jem Newton discovered that they all have value.
A model for the evaluation of chiropractic methods. (1987)

A model is proposed for the evaluation of the procedures and practices taught within a chiropractic curriculum. Questions concerning definitions, methods of observation, science consistency, and pertinent research are asked of a given procedure in the form of a decision-making flow chart. Based on this analysis, a status is assigned that establishes a procedure's current understanding. Applications of the model are discussed.
Overlay-based side-channel countermeasures: A case study on correlated noise generation (2017)

Side-channel attacks against field-programmable gate arrays (FPGAs) enable attackers to reverse-engineer bitfile encryption keys, resulting in intellectual-property (IP) theft and tampering. To address this problem, we demonstrate that overlays - virtual architectures implemented atop an FPGA - provide a novel countermeasure strategy that can protect application IP even on vulnerable FPGAs. Although we demonstrate such protection via a case study on correlated noise generation, the approach is potentially applicable to any countermeasure and any overlay. By extending existing overlay benefits (e.g., fast compilation, application portability, 1000× smaller bitfiles) with improved hardware security, our approach provides an attractive platform for Internet of Things, defense, and many embedded applications.
Fabrication of nanoscale gaps using a combination of self-assembled molecular and electron beam lithographic techniques (2006)

We have developed and tested a new method of fabricating nanogaps using a combination of self-assembled molecular and electron beam lithographic techniques. The method enables us to control the gap size with an accuracy of approximately 2nm and designate the positions where the nanogaps should be formed with high-resolution patterning by using electron beam lithography. We have demonstrated the utility of the fabricated nanogaps by measuring a single electron tunneling phenomenon through dodecanethiol-coated Au nanoparticles placed in the fabricated nanogap.