gebhart/patrepeval huggingface dataset:
Mode of Inoculation of the Lyme Disease Agent Borrelia burgdorferi Influences Infection and Immune Responses in Inbred Strains of Mice (1993)

Mice were infected with Borrelia burgdorferi by infection via Ixodes ricinus and experimental inoculation to determine whether transmission rates of spirochetes and antibody responses are influenced. Mice infected by the natural route were substantially more infective for ticks; two- to sixfold more tick larvae were positive for B. burgdorferi than those fed on experimentally inoculated mice. In natural infection, spirochetemia may be greater or spirochetes may be more accessible for transmission. Thus, this form of xenodiagnosis could be used to determine levels of spirochetes in the vertebrate host. Similar levels of antibody were present in all mice; however, those infected by the natural route lacked antibodies to outer surface proteins (Osp) A and B. The small antigen dose given through a tick bite may not have been sufficient to induce rapid OspA or OspB antibodies, thereby allowing the later development of higher levels of spirochetemia.
Variables Affecting In Vivo Performance of High-Capacity Adenovirus Vectors (2002)

In high-capacity adenovirus (HC-Ad) vectors the size and/or composition of the vector genome influences vector stability during production and the expression profile following gene transfer. Typically, an HC-Ad vector will contain both a gene or an expression cassette and stuffer DNA that is required to balance the final vector genome to a size of between 27 and 36 kb. To gain an improved understanding of factors that may influence gene expression from HC-Ad vectors, we have generated a series of vectors that carry different combinations of human alpha-1 antitrypsin (hAAT) expression constructs and stuffer DNAs. Expression in vitro did not predict in vivo performance: all vectors expressed hAAT at similar levels when tested in cell culture. Hepatic expression was evaluated following in vivo gene transfer in C57BL/6J mice. hAAT levels obtained from genomic DNA were significantly higher than levels achieved with small cDNA expression cassettes. Expression was independent of the orientation and only marginally influenced by the location of the expression cassette within the vector genome. The use of lambda stuffer DNA resulted in low-level but stable expression for at least 3 months when higher doses were applied. A potential matrix attachment region element was identified within the hAAT gene and caused a 10-fold increase in expression when introduced in an HC-Ad vector genome carrying a phosphoglycerate kinase (pgk) hAAT cDNA construct. We also illustrate the influence of the promoter on anti-hAAT antibody formation in C57BL/6J mice: a human cytomegalovirus but not a pgk promoter resulted in an anti-hAAT antibody response. Thus, the overall design of HC-Ad vectors may significantly influence amounts and duration of gene expression at different levels.
Dynamic reconfiguration of distributed applications (1993)

Applications requiring concurrency or access to specialized hardware are naturally written as distributed applications, where each software component (module) can execute on a different machine, and modules interact via bindings. In order to make changes to very long-running applications or those that must be continuously available, we must dynamically change the application. Dynamic reconfiguration of a distributed application is the act of changing the configuration of the application as it executes. Examples of configuration changes are replacing a module, moving a module to another machine, and adding or removing modules from the application. The most challenging aspect of dynamic reconfiguration is that an application in execution has state information, both within the modules and within the communication channels between modules. This state information may need to be transferred from the old configuration to the new in order to reach an application state compatible with the new c...
Low-phase-error offset-compensated switched-capacitor integrator (1990)

A modification of the offset-compensated switched-capacitor integrator is described. The resulting circuit has a reduced delay and low gain distortion. It also retains the simplicity and low phase errors of earlier schemes.
Recycling Mg(OH)<sub>2</sub>Nanoadsorbent during Treating the Low Concentration of Cr<sup>VI</sup> (2011)

Investigations about how to recycle the deactivated nanomaterials are well-needed. This work was designed to explore the recycling strategy of Mg(OH)(2) nanoadsorbent during treating low concentration of Cr(VI) solution as an example. It was demonstrated that a reversible route between Cr-adsorbed nano-Mg(OH)(2) and Cr-desorbed bulk-MgCO(3) · 3H(2)O can be established by using CO(2) as a phase transformation medium. In each adsorption-desorption cycle, Cr(VI) solution with initial concentration of 10 mg · L(-1) could be enriched over 40 times. An aggregation-induced rapid phase transformation mechanism from nano-Mg(OH)(2) to bulk-MgCO(3) · 3H(2)O was discovered, which was one of the critical factors to ensure the disposing efficiency of this environmental-friendly Cr(VI) disposal system. A pilot-scale experiment was conducted with this strategy to deal with 50 L Cr(VI)-containing simulated industrial wastewater. The enrichment of Cr(VI) and the recycle of nano-Mg(OH)(2) can be successfully achieved simultaneously.
Preparation of retinamides by use of retinoyl fluoride. (1985)

Retinoyl fluoride (2) prepared from retinoic acid (1) by reaction with diethylaminosulfurtrifluoride is a stable crystalline compound not easily hydrolyzed by water. By reacting retinoyl fluoride with water-soluble amines in the presence of sodium bicarbonate, retinamide (4), N-retinoyl glycine (6), N-retinoyl DL-phenylalanine (7), alpha-N-retinoyl-L-lysine (11), N-retinoyl 4-aminophenol (4-hydroxyphenylretinamide) (8), and N-retinoyl-2-amino-2-deoxy-D-glucose (2-deoxy-D-glucose-2-retinamide) (9) have been prepared in good yields and characterized by UV absorption, 1H NMR, IR spectra, mass spectrometry, and elemental analysis.
A hierarchical Bayesian approach to record linkage and population size problems (2011)

We propose and illustrate a hierarchical Bayesian approach for matching statistical records observed on different occasions. We show how this model can be profitably adopted both in record linkage problems and in capture–recapture setups, where the size of a finite population is the real object of interest. There are at least two important differences between the proposed model-based approach and the current practice in record linkage. First, the statistical model is built up on the actually observed categorical variables and no reduction (to 0–1 comparisons) of the available information takes place. Second, the hierarchical structure of the model allows a two-way propagation of the uncertainty between the parameter estimation step and the matching procedure so that no plug-in estimates are used and the correct uncertainty is accounted for both in estimating the population size and in performing the record linkage. We illustrate and motivate our proposal through a real data example and simulations.
Neurofibrillary tangles in senile dementia of the Alzheimer type share an antigenic determinant with intermediate filaments of the vimentin class. (1983)

A monoclonal antibody produced by a hybridoma between a plasmacytoma cell and a spleen cell from a mouse immunized with human brain microtubule fraction was demonstrated to stain neurofibrillary tangles of senile dementia of the Alzheimer type (SDAT). The antibody recognized at least 50% of the tangles in neuronal perikarya isolated from SDAT brains and stained a filamentous network in HeLa cells, fibroblasts, and astrocytes. It did not stain skin epithelial cells or neurons isolated from normal brains but reacted with Z bands in skeletal muscle. The monoclonal antibody stained coils in colchicine or colcemid-treated cultured cells in a pattern characteristic of 10-nm intermediate-sized filaments. Immunoblotting of Triton-insoluble cytoskeletal proteins of cultured cells electrophoresed in SDS polyacrylamide gels showed that the antigenic determinant is present in proteins of molecular weight 58,000 which comigrates with vimentin. Thus, it appears that the neurofibrillary tangles in SDAT share an antigenic determinant with vimentin.
Comparative Toxicity of Fluorinated Lipids and Their Evaluation as Bait-Block Toxicants for the Control of Reticulitermes spp. (Isoptera: Rhinotermitidae)1 (1983)

Journal Article Comparative Toxicity of Fluorinated Lipids and Their Evaluation as Bait-Block Toxicants for the Control of Reticulitermes spp. (Isoptera: Rhinotermitidae) Get access Glenn D. Prestwich, Glenn D. Prestwich Search for other works by this author on: Oxford Academic PubMed Google Scholar Joe K. Mauldin, Joe K. Mauldin Search for other works by this author on: Oxford Academic PubMed Google Scholar John B. Engstrom, John B. Engstrom Search for other works by this author on: Oxford Academic PubMed Google Scholar Joan F. Carvalho, Joan F. Carvalho Search for other works by this author on: Oxford Academic PubMed Google Scholar Doreen Y. Cupo Doreen Y. Cupo Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Economic Entomology, Volume 76, Issue 4, 1 August 1983, Pages 690–695, https://doi.org/10.1093/jee/76.4.690 Published: 01 August 1983 Article history Received: 21 June 1982 Accepted: 15 February 1983 Published: 01 August 1983
Two year olds in ECE: A policy issue for New Zealand? (2016)

A growing number of 2 year olds are now attending early childhood education (ECE) services nationally and internationally. However, New Zealand has been slow to address the specialist provision and needs for high quality ECE for 2 year olds. The current survey of 248 New Zealand ECE services examined the effect of this lacuna on practice and provision. The results show a lack of adequate funding for provision and emphasise the importance of optimal child-teacher ratios for 2 year olds. Safety, supervision, space, relational, and associated curriculum issues that balance routine, play, and other activities were identified as challenges the ECE services face in providing quality ECE for 2 year olds. Suggestions in terms of better ratios, flexible spaces, professional support for teachers, and New Zealand-based research are offered as priority areas for policy revision. We argue that granting serious attention to these issues would respond better to claims that ECE participation is beneficial for this age group, and in doing so bring New Zealand into alignment with other countries internationally.
An investigation of the removal of 1-Methyl-2-Pyrrolidinone (NMP) (2006)

Molecular bases have long been known to be a problem in photolithographic applications using chemically amplified photoresists. Of these molecular bases, ammonia and 1-methyl-2-pyrrolidinone (NMP) have been studied in the most detail since chemical filtration of these contaminants is critical to the success of the photolithographic process. It has been well documented that ammonia is best removed through chemisorptive reactions using acid impregnated adsorbents or strong acid ion exchange resins. However, the mechanism(s) for the removal of NMP has not been investigated to any significant extent. There are several chemical filtration systems available that employ activated carbon, impregnated activated carbon, or ion exchange resins for the removal of NMP. This work investigates the removal of NMP using several different types of adsorbents and rationalizes the adsorption mechanism which is operative in each situation.
Epitaxial Films of Silicon on Sapphire Formed by Vacuum Evaporation and Their Electrical Properties (1968)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Tadatsugu Itoh, Shinichi Hasegawa, Hisatsune Watanabe; Epitaxial Films of Silicon on Sapphire Formed by Vacuum Evaporation and Their Electrical Properties. J. Appl. Phys. 1 May 1968; 39 (6): 2969–2971. https://doi.org/10.1063/1.1656708 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioJournal of Applied Physics Search Advanced Search |Citation Search
Motion planning of walking robots using ordinal optimization (1998)

A general approach for coordinating the legs of a multi-legged statically stable walking machine on an uneven terrain. The method of ordinal optimization is used to find a good motion plan for low travel time that specifies the footholds and the gait of the walking machine. Numerical simulations illustrate the approach and demonstrate that we can find a good motion plan for uneven terrain with high complexity in a reasonably short time.
Differential effects of protein kinase a sub‐units on chinese‐hamster‐ovary cell cycle and proliferation (1994)

It has been shown that a marked increase in the levels of RI alpha sub-units and a decrease in RII beta sub-unit levels correlate with neoplastic transformation or with the mitogenic response of normal cells to hormones and growth factors. The selective down-regulation of RI alpha and the following induction of RII beta determine cell-growth arrest and differentiation of several cancer cells. To directly address the question whether the 2 protein-kinase-A(PKA) isoforms play different roles in the control of proliferation and cell-cycle distribution, we introduced and over-expressed the different PKA sub-units in Chinese-hamster-ovary (CHO) cells via retroviral-vector-mediated gene transfer. Whereas CHO cells treated with RI alpha anti-sense oligodeoxynucleotides were growth arrested and accumulated in the G0/G1 phases of the cell cycle, infection of CHO cells with a retroviral vector in order to over-express RI alpha determined growth advantages in monolayer conditions and substantially increased their cloning efficiency in soft agar. These events correlated with a sustained percentage of cells in S phase induced by RI alpha over-expression in the infected cells. In contrast, CHO cells infected with retroviral vectors over-expressing either a RII beta sub-unit or a C alpha catalytic sub-unit of PKA exhibited growth arrest within a few days of culture and accumulated in the G2-M phase of the cell cycle. The results of our study demonstrate that the different PKA sub-units play different and specific roles in the control of cell growth and cell-cycle distribution.
Phosphorus(III)-Mediated Stereoconvergent Formal [4+1]-Cycloannulation of 1,2-Dicarbonyls and <i>o</i>-Quinone Methides: A Multicomponent Assembly of 2,3-Dihydrobenzofurans (2016)

A phosphorus(III)-mediated formal [4+1]-cycloaddition of 1,2-dicarbonyls and o-quinone methides to provide 2,3-dihydrobenzofurans is described. By exploiting the carbene-like nature of dioxyphospholenes, dihydrobenzofurans bearing a quaternary center at C2 are obtained in 30-92% yield with diastereoselectivities up to ≥20:1. This study highlights the subtle steric interactions involved in the [4+1]-cycloannulation and the impact they have on yield and stereoselectivity in dihydrobenzofuran formation.
Konst. I. Vourveris: Φιλολογίαα ώςc Πνενματική Επιστήμη Pp. 112. Athens, 1952. Paper. (1954)

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Mechanism of the transient stimulated Rayleigh scattering in liquids (1986)

In this paper we present a new theoretical approach to the transient stimulated scattering of light. It was shown that a light-induced grating giving rise to stimulated scattering can be depicted in terms of nonlinear Volterra equations. Taking advantage of this approach we made a detailed study of the mechanism of transient stimulated Rayleigh scattering (SRLS), for which the pulse duration of laser light and the rise time of the isobaric modulations of the dielectric functions are of the same order. Assuming a small depletion of laser-light intensity only, we derive expressions describing the spatially and temporally resolved distributions of isobaric modulations of the dielectric function and of the optical field. From our analysis it follows that SRLS is generated only if a phase mismatch between the optical field and the light-induced isobaric grating occurs. Such a phase mismatch is due to the finite rise time of the grating. The calculations confirm that in absorbing liquids the appearing local heating determines the generation of isobaric gratings. Furthermore they put into evidence that in transparent liquids electrostriction and the optical Kerr effect become significant. The hitherto unexplained shift in the spectrum of SRLS in transparent liquids should now be related to the optical Kerr effect. It was also found that for some experimental conditions a significant part of SRLS reveals a wave front reversed to the incident laser field.
Dynamic root exudation of sorgoleone and its in planta mechanism of action (2009)

The oily droplets exuded from the root hairs of sorghum are composed of a 1:1 ratio of sorgoleone and its lipid resorcinol analogue. The production of these droplets appears to be suppressed when c. 20 microg of exudate mg(-1) root dry weight accumulates at the tip of the root hairs. However, more exudate is produced following gentle washing of the roots with water, suggesting that the biosynthesis of lipid benzoquinones and resorcinols is a dynamic process. Sorgoleone interferes with several molecular target sites, including photosynthetic electron transport, in in vitro assays. However, the in planta mechanism of action of sorgoleone remains controversial because it is not clear whether this lipid benzoquinone exuding from the roots of sorghum is taken up by roots of the receiving plants and translocated to their foliage where it must enter the chloroplast and inhibit PSII in the thylakoid membrane. Experiments designed to test the in planta mode of action of sorgoleone demonstrated that it has no effect on the photosynthesis of older plants, but inhibits photosynthesis in germinating seedlings. Sorgoleone is not translocated acropetally in older plants, but can be absorbed through the hypocotyl and cotyledonary tissues. Therefore, the mode of action of sorgoleone may be the result of inhibition of photosynthesis in young seedlings in concert with inhibition of its other molecular target sites in older plants.
CONTROL-THEORETIC DYNAMIC MODELING AND ANALYSIS OF A PRODUCTION SYSTEM By (2013)

This research is focused on combining the analytical and experimental based techniques to design, model and analyze a production system under the impact of a rush order using principles from classical control theory. This work provides a suite of transient performance metrics to study and assess the performance of a production system under the impact of a disturbance. A graphical root locus technique from classical control theory is introduced in the production system realm as a way to aid in designing control policies that affect the dynamic control system performance. This research additionally provides a framework by which real time data can be harnessed to generate dynamic control actions on the shop floor as a proactive mechanism in response to external and internal disturbances. This approach is tested on a three-workstation, homogeneous, tandem, single entrant line that has infinite supply of raw material to the system. This proposed model is a continuous flow aggregate model where the part discreteness constraint is relaxed.Findings and Conclusions: In this study, PID control policy is found to perform better than a proportional control policy in terms of better control efficiency and improved profitability in the face of a rush order. Also, the degree of flexibility is also assessed by the production system's ability to respond to disturbances by studying its impact on the suite of performance metrics in terms of delay and quantization on the production system's performance. Based on this analysis, an increased quantization of capacity resulted in a stronger dead band that the controller needed to work against and results in less frequent and less alternating controller action. On the other hand, high quantization levels led to higher percentage throughput overshoot. Also, the effect of the production system delay is analyzed using the root locus plot and its effect on the production system response.
Time-scaling of sinusoids for intelligent jitter buffer in packet based telephony (2003)

Two packet loss combating schemes for voice over packet switched networks are studied. The methods are based on time-scaling performed directly on the parameters of a harmonic sinusoidal speech model and are implemented at the receiving end only. Subjective listening tests show promising results indicating the potential of sinusoidal coding schemes for voice-over-IP (VoIP).
An Advanced Instrument for the Real Time Measurement of Engine Oil Economy (1992)

<div class="htmlview paragraph">A number of advancements have been made in the coulometric sulfur trace instrumental technique for the real-time measurement of engine oil economy. These advancements include modification of the coulometric cell to improve reliability and reproducibility. The instrument has been interfaced with a microcomputer for instrument control as well as data acquisition, storage, and analysis. Studies were undertaken which demonstrate sufficient sensitivity and linearity for determination of engine oil economy at levels better than 10,000 miles/quart. Applications to steady-state engine oil consumption mapping and to instantaneous oil consumption during transient engine cycling are described. These instruments are being produced by an outside supplier for use in various company locations in both the engine production and engine research environments.</div>
Skeletal myoblasts utilize a novel beta 1-series integrin and not alpha 6 beta 1 for binding to the E8 and T8 fragments of laminin. (1991)

The E8 fragment of laminin stimulates myoblast attachment and locomotion. Myoblast attachment to laminin/E8 was blocked by anti-integrin antibodies against beta 1-chains but not by antibodies against alpha 6-chains. By contrast, other cell lines (e.g. B16, HT1080, P19, F9, Pys2, 3T3, and 3T6) were blocked both by anti-beta 1 and anti-alpha 6. All cells tested also bound to approximately 125-kDa C-terminal fragments of E8 (T8 and T8'). Immunoprecipitation of surface-iodinated myoblasts revealed beta 1-, alpha 3-, and alpha 5-integrin chains and a novel chain that co-precipitated with anti-beta 1 antibodies running at approximately 95 kDa (reduced). I125-alpha 6 beta 1 was immunoprecipitated from cells whose attachment to E8 was blocked by anti-alpha 6 antibodies. By contrast, little alpha 6 beta 1 could be immunoprecipitated from myoblasts. beta 1-Integrin and the novel alpha-chain (alpha'), Mr approximately 120,000/approximately 95.000 (nonreduced/reduced), from myoblast lysates were retained during affinity chromatography on Engelbreth-Holm-Swarm-laminin affinity columns. beta 1, alpha 1, and the novel alpha' were retained from Rugli cell lysates on Engelbreth-Holm-Swarm-laminin columns. alpha 3 was not bound. When E8 was used as affinity matrix, only beta 1 and alpha' were retained. The N-terminal sequence of Rugli alpha' was homologous to alpha-chains of beta 1-series integrins and was most similar to alpha 6 (9 identical residues out of 14). However, there were distinctive differences; in particular, 2 residues were deleted in comparison with alpha 6.