gebhart/patrepeval huggingface dataset:
Hepatic lipid peroxidation in vivo in rats with chronic iron overload. (1983)

A C T Peroxidative decomposition of cellular membrane lipids is a postulated mechanism of hepa- tocellular injury in parenchymal iron overload. In the present study, we looked for direct evidence of lipid peroxidation in vivo (as measured by lipid-conjugated diene formation in hepatic organelle membranes) from rats with experimental chronic iron overload. Both parenteral ferric nitrilotriacetate (FeNTA) administration and dietary supplementation with carbonyl iron were used to produce chronic iron overload. Bio- chemical and histologic evaluation of liver tissue con- firmed moderate increases in hepatic storage iron. FeNTA administration produced excessive iron de- position throughout the hepatic lobule in both hepa- tocytes and Kupffer cells, whereas dietary carbonyl iron supplementation produced greater hepatic iron overload in a periportal distribution with iron depo- sition predominantly in hepatocytes. Evidence for mitochondrial lipid peroxidation in vivo was demon- strated at all three mean hepatic iron concentrations studied (1,197,3,231, and 4,216 ,g Fe/g) in both mod- els of experimental chronic iron overload. In contrast, increased conjugated diene formation was detected in microsomal lipids only at the higher liver iron con- centration (4,161 ug Fe/g) achieved by dietary car- bonyl iron supplementation. When iron as either FeNTA or ferritin was added in vitro to normal liver homogenates before lipid extraction, no conjugated diene formation was observed. We conclude that the presence of conjugated dienes in the subcellular frac-
Intravenous Administration of Magnesium Sulfate in Acute Stroke: A Randomized Double-blind Study (2001)

A randomized, placebo-controlled, double-blind study was performed as a pilot study to examine the benefit of the administration of magnesium sulfate given intravenously as a protective substance during the first 24 hours following a stroke. Patients who had cortical infarction in the middle cerebral artery territory with moderate to severe neurologic deficits lasting for more than 15 minutes with onset less than 24 hours were included. The patients were treated with magnesium sulfate or placebo for 5 days and examined by a blinded investigator. Patients had follow-up for 30 days. The primary efficacy variable was the proportion of patients reaching mild to moderate neurologic deficit on the Orgogozo scale (80 points) and relative functional independence on the Barthel index (60 points). Orgogozo scale and Mathew scale values were obtained on admission and days 2, 4, 8, and 30 after stroke. Barthel activities of daily living index and Rankin disability score were obtained on day 30. Forty-one patients (22 given treatment and 19 given placebo) demonstrated significant beneficial effects on the Orgogozo scale (84 +/- 11 vs. 64 +/- 10, p < 0.0001) and (83 +/- 14 vs. 70 +/- 15, p < 0.009), respectively. At the end of 1-month follow-up, the Barthel ADL index was nonsignificantly higher and the Rankin disability score was marginally significantly lower in the magnesium-treated group (84 +/- 26 vs. 71.8 +/- 26, p < 0.143) than in control subjects (2.3 +/- 1.1 vs. 3 +/- 1.3, p < 0.077). Intravenous magnesium sulfate had significant positive effect on the outcome in patients with acute stroke. Further studies on a larger scale are needed to confirm these findings.
A 10 Gbps GFP frame delineation circuit with single bit error correction on an FPGA (2005)

This paper presents the design and study of an architecture able to perform 10 Gbit/s GFP frame delineation with single bit error correction on an FPGA. The design targets the development of a system-on-chip (SoC) platform for the design of next generation network processing. In order to achieve the high processing rate, the circuit is designed with a 64-bit data-path and is targeted to Altera Stratix II FPGA technology. The circuit operates at a clock rate of 165 MHz. The circuit utilises 8 parallel CRC HEC calculators and comparators, a PLI frame counter and a single bit error correction mechanism.
Ecophysiological Studies on the Red Alga <i>Galdieria sulphuraria</i> Isolated from Southwest Iceland (1999)

Abstract: The acido‐ and thermophilic red alga, Galdieria sulphuraria , was isolated from three volcanic areas of the Reykjanes peninsula (southwest Iceland). These sites showed pH values of 1.5 to 3, low concentrations of dissolved organic carbon, and were apparently exclusively colonized by the red alga. No other eucaryotes were observed by light or electron microscopy. The isolated Galdieria strains grew heterotrophically on various sugars and polyols. At all three sites, Galdieria occupied terrestrial habitats. Extensive endolithic growth of the alga was only observed at one site where cell layers were found as deep as 3 cm within rocks of geyserite, a soft white siliceous mineral. Light is apparently insufficient for photosynthesis >10 mm below the stone surface. It is proposed that cells deep within the rock make use of metabolites released by decaying cells in the surroundings. Cells isolated from these algal layers exhibited sugar uptake rates indicative for a low‐level heterotrophic state. Therefore, the extraordinary heterotrophic capabilities of Galdieria seem to be especially important in endolithic habitats.
Problems of Yield Control and Inventory in British Forestry (1960)

Part I. The greater part of the output from British forests during the next few years will come from thinnings. Final fellings will come predominantly from overmature crops which are a legacy from the past or from unsatisfactory crops. Yields from thinning and felling must therefore be cqnsidered quite separately. Thinning yields will depend upon increment but yields from final felling will depend mainly upon the area of overmature crops to be removed within a predetermined period of years. The data required for thinning and felling control are discussed. Part II. The theory of sampling in relation to forest enumeration is discussed briefly. The standing volume of a forest may be estimated in three ways; by the application of yield tables; by visual estimation; or by measurement. The last method may mean measuring all the trees or only a sample and the theory of enumeration plot procedure is discussed. Increment may be estimated by comparing successive enumerations of the standing crop; from yield tables; or from measurements within the tree. Finally the choice of enumeration method is discussed.
Temperature dependent setting kinetics and mechanical properties of β-TCP–pyrophosphoric acid bone cement (2005)

Brushite (CaHPO4·2H2O) is the product of acidic calcium phosphate cement forming reactions. It has a higher solubility than hydroxyapatite under physiological conditions and is a promising resorbable bone cement candidate. It reacts extremely fast so dilute mixes are required to form cements having setting times with surgical utility, which in turn compromises strength and produces a highly porous material. Pyrophosphate ions have a strong affinity for calcium orthophosphate surfaces, can inhibit their mineralisation and are thought to hydrolyze, forming orthophosphate during bone formation. The effect of replacing the acid orthophosphate component of a brushite cement with pyrophosphoric acid on the cement setting reaction time at temperatures of between 24 °C and 70 °C was determined. The substitution of pyrophosphate for orthophosphate retarded setting and improved mechanical performance of the cement. Pyrophosphate did not inhibit the extent of reaction but did influence microstructure of the brushite crystals. Temperature was found to have a significant (p < 0.01) influence on mechanical performance, and this was attributed to the formation of monetite (CaHPO4) rather than brushite at temperatures of ≥55 °C.
Improved insulin sensitivity by calorie restriction is associated with reduction of ERK and p70S6K activities in the liver of obese Zucker rats (2009)

Calorie restriction (CR) improves obesity-related insulin resistance through undefined molecular mechanisms. Insulin receptor substrate (IRS)-1 serine/threonine kinases have been proposed to modulate insulin sensitivity through phosphorylation of IRS proteins. The aim of this study is to test the hypothesis that changes in the activity of IRS1 serine/threonine kinases may underlie the molecular mechanism of CR in improving insulin sensitivity. Obese and lean Zucker rats were subjected to 40% CR or allowed to feed ad libitum (AL) for 20 weeks; body weight and insulin sensitivity were monitored throughout this period. The activity of IRS1 serine/threonine kinases - including JNK, ERK, MTOR/p70(S6K) (RPS6KB1 as listed in the MGI Database), glycogen synthase kinase 3beta (GSK3B), AMPK (PRKAA1 as listed in the MGI Database), and protein kinase C (PRKCQ) in liver tissue extracts was measured by an in vitro kinase assay using various glutathione-S-transferase (GST)-IRS1 fragments as substrates, while phosphorylation of IRS1 and serine kinases was determined by western blotting using phosphospecific antibodies. CR in obese rats significantly reduced body weight and increased insulin sensitivity compared to AL controls. Serine kinase activity toward IRS1(S612) (corresponding to S616 in human IRS1) and IRS1(S632/635) (corresponding to S636/639 in human IRS1) was increased in obese rats compared to lean littermates, and was markedly decreased following CR. Concomitantly, obesity increased and CR decreased the activity of hepatic ERK and p70(S6K) against IRS1. The close association between the activity of hepatic ERK and p70(S6K) with insulin resistance suggests an important role for ERK and p70(S6K) in the development of insulin resistance, presumably via phosphorylation of IRS proteins.
Structural Characterization of the First Example of a Bis(.mu.-thiolato)dicopper(II) Complex. Relevance to Proposals for the Electron Transfer Sites in Cytochrome c Oxidase and Nitrous Oxide Reductase (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructural Characterization of the First Example of a Bis(.mu.-thiolato)dicopper(II) Complex. Relevance to Proposals for the Electron Transfer Sites in Cytochrome c Oxidase and Nitrous Oxide ReductaseRobert P. Houser, Jason A. Halfen, Victor G. Young Jr., Ninian J. Blackburn, and William B. TolmanCite this: J. Am. Chem. Soc. 1995, 117, 43, 10745–10746Publication Date (Print):November 1, 1995Publication History Published online1 May 2002Published inissue 1 November 1995https://pubs.acs.org/doi/10.1021/ja00148a018https://doi.org/10.1021/ja00148a018research-articleACS PublicationsRequest reuse permissionsArticle Views571Altmetric-Citations88LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
‘Sniffin’ Sticks': Olfactory Performance Assessed by the Combined Testing of Odour Identification, Odor Discrimination and Olfactory Threshold (1997)

'Sniffin' Sticks' is a new test of nasal chemosensory performance based on pen-like odor dispensing devices. It comprises three tests of olfactory function, namely tests for odor threshold (n-butanol, testing by means of a single staircase), odor discrimination (16 pairs of odorants, triple forced choice) and odor identification (16 common odorants, multiple forced choice from four verbal items per test odorant). After extensive preliminary investigations the tests were applied to a group of 104 healthy volunteers (52 female, 52 male, mean age 49.5 years, range 18-84 years) in order to establish test-retest reliability and to compare them with an established measure of olfactory performance (the Connecticut Chemosensory Clinical Research Center Test, CCCRC). Performance decreased with increasing age of the subjects (P < 0.001). Coefficients of correlation between sessions 1 and 2 were 0.61 for thresholds, 0.54 for discrimination and 0.73 for identification. Butanol thresholds as obtained with the CCCRC increased as a function of age; this relation to the subjects' age was not found for the CCCRC odor identification task. The test-retest reliability for CCCRC thresholds was 0.36, for odor identification it was 0.60. It is concluded that 'Sniffin' Sticks' may be suited for the routine clinical assessment of olfactory performance.
Integrating home care services in Europe. (2010)

Introduction: A key feature of home care is its divided nature. Conditions for coordination are poor. A variety of professionals provides a coherent mix of services. The social care system is in general local, less professionalised and usually more poorly financed than the health care system. These differences are related to or result in different interests, culture and style and are a ground for communication problems. The existence of this divide will be explored it will be considered what remedies are available and are applied. Methods and Materials: This presentation is drawn upon the results of the EC-financed EURHOMAP project and a discussion between country experts invited to the conference. The study has collected a wealth of data on various types of home care (including nursing care, personal care, domestic aid and respite care). In 31 countries information was gathered on a large set of indicators in the areas of policy & regulation, financing, organisation & delivery and clients & informal carers. Results: Home care services may stem from different sectors, systems and organisations. Several countries have identified and addressed problems related to this situation. However, the degree of splitting varies among countries. It can exist at one or more of the following levels: governance and regulation; entry to the home care system; delivery of services. Furthermore the extent to which the division occurs may differ as well. Integration at governance level creates more favourable conditions for integration at access and delivery level. From a clients’ perspective poor integration may manifest itself both at the point of entry (absence of a clear-cut easy access point), and in the delivery of services (which are not tailored to what is needed or lack flexibility). Conclusion: There are many possible remedies against problems of poor integration; depending on the level and the situation where the problem occurs.(aut. ref.)
Ovation (2011)

Ovation Frank X Walker (bio) i've been watching you double yourself overnight especially after the rains come and you play tug of war with the morning sun for the very last drops of nectar your premature budding and kentucky's persnickety spring made me worry that you might not find your way but I see you up there, fearless and so very alive mimicking a butterfly cavalry, a church full of paper fans, an endless see of little green hands applauding spring's late but timely arrival [End Page 16] Frank X Walker Frank X Walker coined the term, "Affrilachian" to refer to Appalachian African-Americans and founded Pluck! The Journal of Affrilachian Arts and Culture. He is the author of five poetry collections and serves the University of Kentucky as an Associate Professor in the Department of English and the Director of the African American and African Studies Program. Copyright © 2011 Berea College
A Spinning Current Circuit for Hall Measurements Down to the Nanotesla Range (2017)

The spinning current modulation technique is shown not only to be able to suppress all the offset and low-frequency noise contributions from the Hall sensing element and its preamplifier, but it may also suppress the parasitic signals, such as pickup noise and thermal electromotive force contributed by the interconnects in a hybrid Hall plate/driving electronics system with remote Hall sensor head. The selection process of an adequate modulation sequence achieving this goal is detailed. The optimization of the elements involved in the analog circuitry, including the analog switches, differential amplifiers, filters, interconnects, and so on, for given measurement conditions is discussed. A printed circuit board aimed at optimizing the operating conditions for a broad spectrum of Hall sensor types and applications, using pluggable modules for adapting the gain and transfer function, is presented. The modulation sequence, modulation frequency, and fine-tuning of the delays involved in the spinning sequence are adjustable by software. With this circuit board and the optimized spinning sequence, we show that the parasitics originating from the interconnection in a hybrid Hall microsystem with remote sensor 1.5 m away can indeed be suppressed. We demonstrate an offset reduction by about four decades, from 630 μT down to less than 100 nT for a system with +/-35-mT full scale. The residual noise has a white spectrum down to at least 60 mHz, close to the Johnson-Nyquist thermal noise. A detectivity of 30 nT down to the sub-Hz range is demonstrated.
Taking CO2 Enhanced Oil Recovery to the Offshore Gulf of Mexico (2014)

Abstract This paper evaluates the recoverable crude oil resource associated with applying carbon dioxide enhanced oil recovery (CO2 EOR) to reservoirs in the offshore Gulf of Mexico (GOM). Using data maintained by the Bureau of Ocean Energy Management (BOEM), a database containing 531 oil fields with a total original oil in-place (OOIP) of 69 billion barrels was used for the study. A total of 391 fields, representing 35% of the OOIP, were screened out at as not amenable to CO2 EOR based on size, residual oil saturation, and/or well-spacing. For the remaining 140 oil fields (containing 696 reservoirs), the data elements required to model a CO2 EOR flood, such as sweep efficiency and heterogeneity, were derived using a variety of methods. Crude oil production and CO2 demand profiles were produced from stream-tube finite-difference simulations for each oil-bearing reservoir. The study assumes that groups of proximate fields will be served by an anchor CO2 supply pipeline (one billion scf per year CO2) at a levelized transportation cost of $1.06/MscfCO2 (equivalently 20$/mtCO2). The economic determinations are based on a crude oil price of $90/bbl, CO2 price of $1.59/Mscf (30 $/MtCO2) at the capture facility plant gate, 18.75% royalty, and a 20% rate of return before taxes. BOEM projects that 182 billion barrels of OOIP remain undiscovered, two and a half times the discovered resource. Data from the analysis of discovered oil fields was used to estimate the expected CO2 EOR oil recovery from the undiscovered oil fields. Under the current CO2 EOR Technology scenario, the economically recoverable resources (ERR) is 0.8 billion barrels, a small fraction of the technically recoverable resource (TRR) of 23.5 billion barrels. The average efficiency of CO2 use in the ERR oil fields is estimated to be 7.2 Mscf/bbl and the associated demand for CO2 supply is 5.8 TCF. Under a scenario with Next Generation CO2 EOR performance, the ERR increases significantly to 14.9 billion barrels and 74 TCF of CO2 demand, consistent with an improved use efficiency of 5.0 MscfCO2/bbl.
Thulium fiber laser lithotripsy: An in vitro analysis of stone fragmentation using a modulated 110-watt Thulium fiber laser at 1.94 µm (2005)

The high-power Thulium fiber laser, when operated in pulsed mode, is capable of fragmenting both soft (UA) and hard (COM) urinary stones. The Thulium fiber laser may be useful as a single laser system for use in multiple soft and hard tissue laser ablation applications in urology.
Further Studies on the Synthesis of Substituted Ureas (1954)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFurther Studies on the Synthesis of Substituted UreasDonald G. Crosby and Carl NiemannCite this: J. Am. Chem. Soc. 1954, 76, 17, 4458–4463Publication Date (Print):September 1, 1954Publication History Published online1 May 2002Published inissue 1 September 1954https://doi.org/10.1021/ja01646a051Request reuse permissionsArticle Views694Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (780 KB) Get e-Alertsclose Get e-Alerts
Combined 8-methoxypsoralen and black light therapy of psoriasis TECHNIQUE AND RESULTS (1974)

Seventy-four patients with psoriasis underwent a combined topical treatment with an 8-methoxypsoralen solution and black light. In thirty-four patients the skin lesions healed; in twenty-three patients they improved considerably. Eleven patients showed only a moderate regression of the lesions, whilst in six patients treatment was for various reasons discontinued during the first phase, The 8-methoxypsoralen-black light therapy can be performed in out-patients and has the advantage over dithranol treatment of being entirely clean. Relapses are not resistant to further similar treatment.
Propagation loss characteristics of long silica-based optical waveguides on 5 inch Si wafers (1993)

The propagation loss characteristics of silica-based optical waveguides with various bending curvatures fabricated on 5 inch Si wafers are investigated. Low loss waveguides more than lm long with a Δ of 0.75% are successfully fabricated and the loss is found to be independent of the curvature radius over 5mm. A minimum loss of 3.5dB/m at ∼1.55 μm is obtained in a waveguide 1.6 m long.
Elongational viscosity of polymer melts: A lubricated skin-core flow approach (1996)

Previous work by this research group has shown that the use of a lubricated skin/core flow of polymer melts and a hyperbolic converging die results in an essentially pure elongational flow at a constant elongational strain rate in the core. The previous work was carried out on a laboratory-scale coextrusion system in a planar slit die; tracer particles and an image analysis system were used to confirm the predicted behavior. In this work, the technique was implemented first on the coextruder assembly, as a planar elongational rheometer, and then on a commercial capillary rheometer, as a uniaxial elongational rheometer for polymer melts. The later is achieved by replacing the standard capillary die with a hyperbolic axisymmetric die. A two-laycred billet is prepared for placement in the rheometer barrel by completely encapsulating the core polymer (the polymer to be analyzed) with a low-viscosity polyethylene skin. Commercial grades of polypropylenes, syndiotactic polystyrene, and nylon-66 were analyzed using this technique. Elongational viscosity at high extensional rates can be determined with this method; values in excess of 500 s−1 have already been achieved. © 1996 John Wiley & Sons, Inc.