gebhart/patrepeval huggingface dataset:
Non-contact Liquid Rationing System Based on Compound Intelligent Control (2010)

In biomedical areas,thousands of reagents with different viscosities and various desired volume need to be dispensed in submicroliter range simultaneously.Therefore,most of the commercial automated liquid dispensing systems need to be calibrated through experiment to accurately dispense liquids when the reagents viscosities change,which is time consuming and not accurate enough.A high-throughput self-adjusted precise liquid handling system is developed,in which a MEMS flow sensor is used.The system construction is introduced in detail.A novel closed-loop control strategy based on compound intelligent fuzzy control method is proposed to calculate the valve open time in each dispensing cycle,which makes the system immune to liquid viscosity,pressure fluctuation,and other sources of error.Dispensing results show that the system can achieve better dispensing performance,and the coefficient of variance(CV) for liquid dispensing is below 3% at 1 μL and below 4% at 100 nL.
Lunar capture orbits, a method of constructing earth moon trajectories and the lunar GAS mission (1987)

A method is described to construct trajectories from the earth to the moon which utilizes the existence of lunar capture orbits and the concept of 'stability boundary'. These orbits are ballistic and represent a new family of trajectories. They go into orbit about the moon from a suitable position about the earth with no required thrusting. This method is applied to a mission being studied at JPL called Lunar GAS (Get Away Special). Other applications are discussed.
A dual-band high efficiency CMOS transmitter for wireless CDMA applications (2007)

A dual-band transmitter integrated circuit (TxIC), including baseband filter and variable gain amplifier (VGA), upconverter, RF VGA, driver amplifier (DA), is implemented in 0.18um CMOS for CDMA applications. The TxIC increases the handset talk time dramatically with the PA-bypass feature. The chip provides more than a total power control range of 80dB and a fine gain step of 0.25dB/LSB. The chip achieves 52.3dBc ACPR at +7dBm output power with 52.2mA and 51.7dBc ACPR at +7dBm output power with 51.9mA for low band and high band applications respectively.
A Modified Proportional–Integral Loop Filter to Suppress DCO Noise in Digital PLL (2018)

Although often analyzed as a second-order system, digital phase-locked loop (DPLL) is actually a third-order system because of the intrinsic latency in the loop filter. The extra pole introduced by this additional clock latency requires the loop filter bandwidth to be correspondingly reduced to ensure stability. In many applications, however, the loop bandwidth needs to be as wideband as possible, since the digital-controlled oscillator (DCO) is often the dominant source of noise. A modified proportional-integral (PI) loop filter is proposed to widen the loop bandwidth. The proposed loop filter employs an additional internal feedback loop that causes a third-order DPLL system to effectively behave as a second-order system. The proposed loop filter is derived based on the observer-controller DPLL. An intuitive explanation based on pole-zero analysis suggests that a wider loop bandwidth can be employed than in the conventional PI loop filter, because the proposed loop filter pushes the extra pole to a higher frequency than in the conventional loop filter. Similarly, for the same open-loop unity gain frequency and phase margin, the proposed loop filter can place the zero at a higher frequency, enabling greater attenuation of the DCO noise while achieving the same lowpass filtering of the reference clock noise as in the conventional loop filter.
IMMA – INTELLIGENTLY MOVING MANIKINS IN AUTOMOTIVE APPLICATIONS (2014)

CROMM
The Thermal Condensation of Glutamic Acid and Glycine to Linear Peptides<sup>1</sup> (1958)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Thermal Condensation of Glutamic Acid and Glycine to Linear Peptides1Kaoru Harada and Sidney W. FoxCite this: J. Am. Chem. Soc. 1958, 80, 11, 2694–2697Publication Date (Print):June 1, 1958Publication History Published online1 May 2002Published inissue 1 June 1958https://pubs.acs.org/doi/10.1021/ja01544a027https://doi.org/10.1021/ja01544a027research-articleACS PublicationsRequest reuse permissionsArticle Views602Altmetric-Citations98LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Complex Event Processing for Financial Services (2006)

Complex event processing (CEP) is an emerging technology for extracting information from distributed message-based systems. CEP is software used to create and deploy applications that process large volumes of incoming messages or events, analyze those messages or events in various ways, and respond to conditions of interest in real-time. This technology allows users of a system to specify the information that is of interest to them. This paper presents an over-view of complex event processing applied to the domain of financial services demonstrated using a CEP product called AMiT (active middleware technology). Two case studies (in the banking and the insurance industries) are introduced in order to demonstrate the special use of the CEP concept in the financial services domain and the advantages both on built-time and run-time. The various usages of CEP for BAM, messaging, decision-making in financial services applications express the increasing role of CEP in intelligent event-driven financial services solutions
Propulsive efficiency of a flexible hull underwater vehicle (1996)

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Ocean Engineering, 1996.
Soft Electronic Skin for Multi‐Site Damage Detection and Localization (2019)

Abstract Soft‐matter technologies have a potentially central role in wearable computing, human–machine interaction, soft robotics, and other emerging applications that require highly compliant and elastic materials. However, these technologies are largely composed of soft materials that are susceptible to damage and loss of functionality when exposed to real‐world loading conditions. To address this critical challenge, we present a soft responsive material that, like natural nervous tissue, is able to identify, compute, and signal damage in real‐time. The soft composite material contains liquid metal droplets dispersed in an elastomer matrix that rupture when mechanical damage occurs (e.g., compression, fracture, or puncture), creating electrically conductive pathways. The resulting change in local conductivity can be actively sensed and coupled with actuation, communication, and computation in a manner that presents new opportunities to identify damage, calculate severity, and respond to prevent failure within soft material systems. When placed on the surface of a soft, humanoid‐like inflatable structure, the skin can detect puncture damage and control the operation of an embedded fan to prevent deflation.
Urinary tract infections in children after renal transplantation (2008)

Urinary tract infections (UTI) after pediatric kidney transplantation (KTX) are an important clinical problem and occur in 15-33% of patients. Febrile UTI, whether occurring in the transplanted kidney or the native kidney, should be differentiated from afebrile UTI. The latter may cause significant morbidity and is usually associated with acute graft dysfunction. Risk factors for (febrile) UTI include anatomical, functional, and demographic factors as well as baseline immunosuppression and foreign material, such as catheters and stents. Meticulous surveillance, diagnosis, and treatment of UTI is important to minimize acute morbidity and compromise of long-term graft function. In febrile UTI, parenteral antibiotics are usually indicated, although controlled data are not available. As most data concerning UTI have been accumulated retrospectively, future prospective studies have to be performed to clarify pathogenetic mechanisms and risk factors, improve prophylaxis and treatment, and ultimately optimize long-term renal graft survival.
Molecular characterization of integrons in non-typhoid Salmonella serovars isolated in Japan: description of an unusual class 2 integron (2005)

In this study, we characterized the antibiotic resistance gene cassettes within class 1 integrons in different isolates of non-typhoid Salmonella serovars, and we also identified a new type of class 2 integron.
Imaging Solute Distribution in Capillary Electrochromatography with Laser Scanning Confocal Microscopy (2002)

A method for the direct observation of solute molecules interacting with a C18 stationary phase under real separation conditions in capillary electrochromatography (CEC) is investigated. The experiments were performed in a capillary electrochromatographic mode; however, the method and findings are useful both in CEC and revered-phase liquid chromatography. The distribution of solute molecules in the packed capillary is directly imaged with laser scanning confocal fluorescence microscopy. Conventional imaging techniques produce images where the C18 silica beads cannot be distinctively identified as a result of the deep depth of field. The optical sectioning capability of confocal imaging overcomes this problem to afford clearly defined images of the stationary-phase packing and the surrounding mobile phase. Fluorescein molecules are preferentially distributed in the mobile phase under reversed-phase chromatographic conditions. Nile Red and rhodamine 6G molecules prefer the environments of the porous C18 beads. Intensity distributions over time for areas within the stationary-phase beads differ from distributions of areas outside the beads in the mobile phase. Images taken at different depths into the capillary probe the internal structure of the C18 beads. While the internal structures of most beads are porous, confocal images show a small fraction (2%) of the silica beads have porous shells and nonporous cores. The capability of imaging the stationary phase distinctively from the mobile phase opens the possibilities of studying the quality of stationary phase, the structure of the column packing, and the mechanisms of separation.
Feature point recognition for the direct teaching data in industrial robot (2011)

Direct teaching in the industrial robot are the novel technique to teach manipulator with easy usage. However, teaching data by human hand cannot help having large noise error ranged low and high frequency. To use teaching data, post processing to correct teaching trajectory are required. Here, the intuitive feature point recognition method to rebuild teaching data with curvature information is proposed.
Penetrating cardiac trauma: Surgical and nursing management (1993)

Penetrating cardiac injuries occur not only in military settings, but also in the civilian arena. This article focuses on the incidence, etiology, and pathophysiology of gunshot wounds and stabbing injuries. Diagnosis, treatment, and surgical approaches of penetrating cardiac injuries are presented. A clinical case study of a left ventricular stabbing injury is described and relevant nursing interventions and follow-up care addressed.
Cutting Edge: TLR9 and TLR2 Signaling Together Account for MyD88-Dependent Control of Parasitemia in <i>Trypanosoma cruzi</i> Infection (2006)

Activation of innate immune cells by Trypanosoma cruzi-derived molecules such as GPI anchors and DNA induces proinflammatory cytokine production and host defense mechanisms. In this study, we demonstrate that DNA from T. cruzi stimulates cytokine production by APCs in a TLR9-dependent manner and synergizes with parasite-derived GPI anchor, a TLR2 agonist, in the induction of cytokines by macrophages. Compared with wild-type animals, T. cruzi-infected Tlr9(-/-) mice displayed elevated parasitemia and decreased survival. Strikingly, infected Tlr2(-/-)Tlr9(-/-) mice developed a parasitemia equivalent to animals lacking MyD88, an essential signaling molecule for most TLR, but did not show the acute mortality displayed by MyD88(-/-) animals. The enhanced susceptibility of Tlr9(-/-) and Tlr2(-/-)Tlr9(-/-) mice was associated with decreased in vivo IL-12/IFN-gamma responses. Our results reveal that TLR2 and TLR9 cooperate in the control of parasite replication and that TLR9 has a primary role in the MyD88-dependent induction of IL-12/IFN-gamma synthesis during infection with T. cruzi.
Acceleration of Hepatitis C Virus Envelope Evolution in Humans Is Consistent with Progressive Humoral Immune Selection during the Transition from Acute to Chronic Infection (2010)

During the transition from acute to chronic infection in individuals persistently infected with hepatitis C virus (HCV), cellular responses initiate within the first 6 months of primary infection and collapse thereafter, whereas humoral responses activate later during the chronic phase. Whether and how this deviation of immune responses specifically influences HCV evolution are unknown. To determine the pattern of HCV evolution during this critical period, we conducted extensive sequence analysis on annual clonal hemigenomic sequences for up to 3 years in six well-characterized subjects, using statistical methods that accounted for repeated measures. Significantly different evolutionary rates were observed in envelope versus nonenvelope genes, with an increasing rate of nonsynonymous change (dN) in envelope genes and a stable dN in nonenvelope genes (P = 0.006). The ratio of the envelope to nonenvelope nonsynonymous rate increased from 2 in year 1 to 5 in years 2 and 3. Centripetal changes (reversions toward matching of the worldwide subtype 1a consensus sequence) were frequently observed during the 3-year transition from acute infection to chronicity, even in the presence of neutralizing antibody (NAb) pressure. Remarkably, sequences of hypervariable region 1 (HVR1) remained stable for up to 21 months in the absence of NAb pressure in one subject, followed by rapid changes that were temporally associated with the detection of NAb responses, which strongly suggests that HVR1 evolution is shaped by NAb pressure. These data provide the first systematic estimates of HCV evolutionary rates in multiple genes during early infection in vivo and provide additional evidence for deterministic, rather than random, evolution of HCV.
1-Deoxy- <scp>d</scp> -Xylulose 5-Phosphate Synthase, the Gene Product of Open Reading Frame (ORF) 2816 and ORF 2895 in <i>Rhodobacter capsulatus</i> (2001)

In eubacteria, green algae, and plant chloroplasts, isopentenyl diphosphate, a key intermediate in the biosynthesis of isoprenoids, is synthesized by the methylerythritol phosphate pathway. The five carbons of the basic isoprenoid unit are assembled by joining pyruvate and D-glyceraldehyde 3-phosphate. The reaction is catalyzed by the thiamine diphosphate-dependent enzyme 1-deoxy-D-xylulose 5-phosphate synthase. In Rhodobacter capsulatus, two open reading frames (ORFs) carry the genes that encode 1-deoxy-D-xylulose 5-phosphate synthase. ORF 2816 is located in the photosynthesis-related gene cluster, along with most of the genes required for synthesis of the photosynthetic machinery of the bacterium, whereas ORF 2895 is located elsewhere in the genome. The proteins encoded by ORF 2816 and ORF 2895, 1-deoxy-D-xylulose 5-phosphate synthase A and B, containing a His(6) tag, were synthesized in Escherichia coli and purified to greater than 95% homogeneity in two steps. 1-Deoxy-D-xylulose 5-phosphate synthase A appears to be a homodimer with 68 kDa subunits. A new assay was developed, and the following steady-state kinetic constants were determined for 1-deoxy-D-xylulose 5-phosphate synthase A and B: K(m)(pyruvate) = 0.61 and 3.0 mM, K(m)(D-glyceraldehyde 3-phosphate) = 150 and 120 microM, and V(max) = 1.9 and 1.4 micromol/min/mg in 200 mM sodium citrate (pH 7.4). The ORF encoding 1-deoxy-D-xylulose 5-phosphate synthase B complemented the disrupted essential dxs gene in E. coli strain FH11.
Tepidicella xavieri gen. nov., sp. nov., a betaproteobacterium isolated from a hot spring runoff (2006)

Strains TU-16T and TU-18, two non-pigmented bacterial isolates with an optimum growth temperature of about 45 degrees C and an optimum pH of about 8.5-9.0, were recovered from the Furnas geothermal area on the Island of São Miguel in the Azores. Phylogenetic analysis of the 16S rRNA gene sequence of these strains indicated that they represent a novel species in a new genus of the phylum Betaproteobacteria. The major fatty acids of strains TU-16T and TU-18 were 16 : 0 and 18 : 1omega7c. Ubiquinone 8 was the major respiratory quinone and the major polar lipids were phosphatidylethanolamine and phosphatidylglycerol. The novel isolates were aerobic; thiosulfate was oxidized to sulfate in the presence of a metabolizable carbon source. The organism assimilated organic acids and amino acids, but did not assimilate carbohydrates or polyols. Based on phylogenetic analyses and physiological and biochemical characteristics, it is proposed that strain TU-16T (=LMG 23030T = CIP 108724T) represents the type strain of a novel species in a new genus, Tepidicella xavieri gen. nov., sp. nov.
A Pill for Impotence (1998)

Impotence — the preferred term is now erectile dysfunction — is a common problem, especially among older men,1 and if it is not caused by psychological problems it certainly can cause them. Among the components of sexual function and satisfaction in men — desire, erectile function, orgasmic function, ejaculation, and fertility — decreased erectile function is not only the most common but also the most distressing and threatening. It can destroy a man's ego and threaten happy relationships.In this issue of the Journal, Goldstein et al. describe the efficacy of oral sildenafil in men with erectile dysfunction.2 This is . . .
The new-generation selective ROS1/NTRK inhibitor DS-6051b overcomes crizotinib resistant ROS1-G2032R mutation in preclinical models (2019)

ROS1 gene rearrangement was observed in around 1-2 % of NSCLC patients and in several other cancers such as cholangiocarcinoma, glioblastoma, or colorectal cancer. Crizotinib, an ALK/ROS1/MET inhibitor, is highly effective against ROS1-rearranged lung cancer and is used in clinic. However, crizotinib resistance is an emerging issue, and several resistance mechanisms, such as secondary kinase-domain mutations (e.g., ROS1-G2032R) have been identified in crizotinib-refractory patients. Here we characterize a new selective ROS1/NTRK inhibitor, DS-6051b, in preclinical models of ROS1- or NTRK-rearranged cancers. DS-6051b induces dramatic growth inhibition of both wild type and G2032R mutant ROS1-rearranged cancers or NTRK-rearranged cancers in vitro and in vivo. Here we report that DS-6051b is effective in treating ROS1- or NTRK-rearranged cancer in preclinical models, including crizotinib-resistant ROS1 positive cancer with secondary kinase domain mutations especially G2032R mutation which is highly resistant to crizotinib as well as lorlatinib and entrectinib, next generation ROS1 inhibitors.
Photon-Impenetrable, Electron-Permeable: The Carbon Nanotube Forest as a Medium for Multiphoton Thermal-Photoemission (2015)

Combining the photoelectric and thermionic mechanisms to generate free electrons has been of great interest since the early days of quantum physics as exemplified by the Fowler-DuBridge theory, and recently proposed for highly efficient solar conversion. We present experimental evidence of this combined effect over the entire range spanning room-temperature photoemission to thermionic emission. Remarkably, the optical stimulus alone is responsible for both heating and photoemission at the same time. Moreover, the current depends on optical intensity quadratically, indicating two-photon photoemission, for intensities of ca. 1-50 W/cm(2), which are orders of magnitude below the intensities required for two-photon photoemission from bulk metals. This surprising behavior appears to be enabled by the internal nanostructure of the carbon nanotube forest, which captures photons effectively, yet allows electrons to escape easily.
Resonant Oscillations Between the Solid Earth and the Atmosphere (2000)

Continuously excited free oscillations of the whole Earth have been found in the ground noise in a frequency band of long-period surface waves. Here we report evidence of an annual variation of this phenomenon, indicating that the excitation source is not within the solid Earth. There is evidence that these seismic free oscillations resonate with acoustic free oscillations of the atmosphere. The observed amplitudes suggest that the excitation source is at or just above Earth's surface.
Optical characteristics of two-dimensional coherently coupled vertical-cavity surface-emitting laser arrays (1993)

We discuss the optical properties of a novel phase-coupled 8 x 8 grid contact vertical-cavity surface-emitting laser array. In addition to the usual out-of-phase array mode, we demonstrate for the first time to our knowledge in-phase surface-emitting laser-array coupling. Four array modes, (1, 1), (1, N), (N, 1), and (N, N), are characterized by comparing far-field distributions and spectra. We introduce a simple physical model to describe our experimental results.
Urocortin 2 infusion in human heart failure (2007)

Intravenous UCN2 in HF induced increases in CO and LVEF with falls in SVR and CW. No hormone response occurred. The role of UCN2 in circulatory regulation and its potential therapeutic application in heart disease warrant further investigation.
A 6.25% Pull-in Range Digital PLL for ISDN Primary Rate Interface LSI (1991)

This paper describes a digital PLL which can realize both wide pull-in range and small output jitter by adopting a self controlled free running frequency. This characteristic is suitable for LSI because the wide pull-in range does not require highly accurate clock and on-chip oscillator can be used. As the result, the expensive external components such as crystals can be eliminated and fully integrated digital PLL is obtained. Circuits are designed for the ISDN primary rate interface LSI. and CCITT I.431 specification are satisfied.