gebhart/patrepeval huggingface dataset:
Effect of ispronicline, a neuronal nicotinic acetylcholine receptor partial agonist, in subjects with age associated memory impairment (AAMI) (2007)

Cognitive decline seen in the normal elderly is associated with selective loss of neuronal nicotinic acetylcholine receptors (nAChRs). Nicotine given either by inhalation or transdermally helps cognition, but unacceptable side effects limit its utility. The present study assessed the safety, tolerability and effect on cognition of ispronicline, a highly selective partial agonist at the 4beta2 nAChR, in elderly subjects (n =76) with age associated memory impairment (AAMI). This double-blind, placebo-controlled cross-over study explored ascending oral doses of ispronicline in the range 50-150 mg given as a single morning dose for a period of 3 weeks. Pharmacokinetics (PK) were assessed, as well as cognitive function measured by means of the Cognitive Drug Research (CDR) computerized test battery. Ispronicline had a favourable safety profile and was well tolerated at doses below 150 mg. No effect of clinical importance was seen on biochemistry, haematology, urine analysis, vital signs, electrocardiogram (ECG) or Holter monitoring. The most frequent drug induced adverse event was light-headedness (dizziness). A beneficial effect was seen on cognition across the dose range. This was most marked at 50 mg on factors measuring attention and episodic memory. PK analysis indicated a plasma Cmax range of 5-25/35 ng/ml ispronicline was associated with the most beneficial effect. These early results demonstrate ispronicline was well tolerated and did not display the side effects typical of nicotine. Ispronicline also had a beneficial effect on cognition in subjects with AAMI. This was seen most strongly in a Cmax range that had been predicted from pre-clinical animal studies.
Multiple behaviors in the cleavage of aryl alkanoates by .alpha.- and .beta.-cyclodextrins. Processes involving two molecules of cyclodextrin (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMultiple behaviors in the cleavage of aryl alkanoates by .alpha.- and .beta.-cyclodextrins. Processes involving two molecules of cyclodextrinOswald S. Tee and Xian Xian DuCite this: J. Am. Chem. Soc. 1992, 114, 2, 620–627Publication Date (Print):January 1, 1992Publication History Published online1 May 2002Published inissue 1 January 1992https://pubs.acs.org/doi/10.1021/ja00028a030https://doi.org/10.1021/ja00028a030research-articleACS PublicationsRequest reuse permissionsArticle Views161Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Association of pain relief with drug side effects in postherpetic neuralgia: A single-dose study of clonidine, codeine, ibuprofen, and placebo (1988)

In a randomized, double-blind crossover study, 40 patients with postherpetic neuralgia were given single oral doses of clonidine, 0.2 mg, codeine, 120 mg, ibuprofen, 800 mg, or inert placebo. Pain relief and side effects were recorded for 6 hours. Patients reported significantly more relief after clonidine than after the other three treatments. Codeine and ibuprofen were ineffective. Sedation, dizziness, and other side effects were more frequent after clonidine (74%) or codeine (69%) than after placebo (36%) or ibuprofen (28%). Reported pain relief was greater during trials in which side effects were present. A single, mild side effect was associated with as much additional pain relief as multiple, severe side effects. Clonidine's superiority to codeine, which had a similar incidence of side effects, argues for a specific analgesic effect. In addition, side effects may have contributed to clonidine analgesia, perhaps by suggesting to patients that they had received a potent drug.
Progressive transmission of line drawings using the wavelet transform (1996)

This paper presents a method to apply progressive transmission to line drawings using the wavelet transform. Experiments have been conducted and showed that the wavelet transform, combined with a quantization step, performs progressive transmission using a data rate comparable to standard chain coding at the expense of almost no visually perceptible distortion.
Ultrastructure of Mansonella ozzardi microfilaria, with a comparison of the South American (simuliid-transmitted) and the Caribbean (culicoid-transmitted) forms. (1983)

Ultrastructural studies conducted to elucidate and compare the microanatomy of the South American (simuliid-transmitted) and the Caribbean (culicoid-transmitted) microfilariae of Mansonella ozzardi revealed that these microfilariae are essentially identical. The only difference detected was the larger central body of the Colombian microfilariae. Although the microanatomy of M. ozzardi microfilaria is essentially the same as that of other microfilariae, some of the subtle differences noted between M. ozzardi and other microfilariae include: amphids of unequal lengths, a large nucleus located approximately 30 microns from the anterior end, and an esophagus which appears to be less developed than that of Loa loa and Brugia spp. The microfilaria has a small cephalic hook, intracellular bacteriae in the hypodermal cells, and crystalloid inclusions which are most prominent in the R-1 cell and are also present in the hypodermal and esophageal cells. These crystalloids appear to be unique to M. ozzardi microfilariae.
Synthesis and Characterization of the Four Geometrical Isomers of 3,5-Dodecadienyl Acetate. (1998)

Practical convergent syntheses of the four geometrical isomers of 3,5-dodecadienyl acetate are presented. These substances have been characterized by NMR and mass spectroscopy. (3E,5Z)-3,5-Dodecadienyl acetate is the main female sex pheromone component of the leaf roller Bonagota cranaodes, which is an important insect pest in apples in South America. The isomeric 3,5-dodecadienyl acetates, as pure isomers and in defined mixtures, have been used as trap lures for Eying insects in field screening experiments in Lithuania. Although no insects were found in the control traps, the numbers of males caught in the baited traps were not high enough to be statistically significant.
Wireless, collaborative virtual sensors for thermal comfort (2010)

Monitoring building performance data for energy-efficiency is an increasing market in which especially wireless sensor networks benefit from their easy installation in existing buildings. Nonetheless, large scale installations are still hampered by sheer installation costs. This paper introduces a virtual sensor approach that utilizes available information in a collaborative network to compute new sensor data. An example is provided in which the approach estimates the thermal comfort with only low-cost temperature sensors in most rooms.
Liquid Chromatography-Tandem and MALDI Imaging Mass Spectrometry Analyses of RCL2/CS100-Fixed, Paraffin-Embedded Tissues: Proteomics Evaluation of an Alternate Fixative for Biomarker Discovery (2009)

Human tissues are an important source of biological material for the discovery of novel biomarkers. Fresh-frozen tissue could represent an ideal supply of archival material for molecular investigations. However, immediate flash freezing is usually not possible, especially for rare or valuable tissue samples such as biopsies. Here, we investigated the compatibility of RCL2/CS100, a non-cross-linking, nontoxic, and nonvolatile organic fixative, with shotgun proteomic analyses. Several protein extraction protocols compatible with mass spectrometry were investigated from RCL2/CS100-fixed and fresh-frozen colonic mucosa, breast, and prostate tissues. The peptides and proteins identified from RCL2/CS100 tissue were then comprehensively compared with those identified from matched fresh-frozen tissues using a bottom-up strategy based on nano-reversed phase liquid chromatography coupled with tandem mass spectrometry (nanoRPLC-MS/MS). Results showed that similar peptides could be identified in both archival conditions and the proteome coverage was not obviously compromised by the RCL2/CS100 fixation process. NanoRPLC-MS/MS of laser capture microdissected RCL2/CS100-fixed tissues gave the same amount of biological information as that recovered from whole RCL2/CS100-fixed or frozen tissues. We next performed MALDI tissue profiling and imaging mass spectrometry and observed a high level of agreement in protein expression as well as excellent agreement between the images obtained from RCL2/CS100-fixed and fresh-frozen tissue samples. These results suggest that RCL2/CS100-fixed tissues are suitable for shotgun proteomic analyses and tissue imaging. More importantly, this alternate fixative opens the door to the analysis of small, valuable, and rare target lesions that are usually inaccessible to complementary biomarker-driven genomic and proteomic research.
An implicit shape model based approach to identify armed persons (2011)

In addition to detecting and tracking persons via video surveillance in public spaces like airports and train stations, another important aspect of a situation analysis is the appearance of objects in the periphery of a person. Not only from a military perspective, in certain environments, an unidentified armed person can be an indicator for a potential threat. In order to become aware of an unidentified armed person and to initiate counteractive measures, the ability to identify persons carrying weapons is needed. In this paper we present a classification approach, which fits into an Implicit Shape Model (ISM) based person detection and is capable to differentiate between unarmed persons and persons in an aiming body posture. The approach relies on SIFT features and thus is completely independent of sensor-specific features which might only be perceivable in the visible spectrum. For person representation and detection, a generalized appearance codebook is used. Compared to a stand-alone person detection strategy with ISM, an additional training step is introduced that allows interpretation of a person hypothesis delivered by the ISM. During training, the codebook activations and positions of participated features are stored for the desired classes, in this case, persons in an aiming posture and unarmed persons. With the stored information, one is able to calculate weight factors for every feature participating in a person hypothesis in order to derive a specific classification model. The introduced model is validated using an infrared dataset which shows persons in aiming and non-aiming body postures from different angles.
Activities of various compounds against murine and primate polyomaviruses (1997)

Polyomavirus infections in humans are due to BK virus (BKV) and JC virus (JCV). Diseases associated with human polyomaviruses occur mostly in immunocompromised adults, e.g., progressive multifocal leukoencephalopathy (PML), caused by JCV, in AIDS patients and hemorrhagic cystitis and uretral stenosis, caused by BKV, in transplant recipients. No therapy is available for these diseases, which necessitates the development of chemical entities that are active against polyomaviruses. Several antiviral compounds were evaluated to determine their effects on the in vitro replication of mouse polyomavirus and the primate viruses simian virus 40 (SV40), SV40 PML-1, and SV40 PML-2. The activity of the different compounds was assessed by a cytopathic effect reduction assay and confirmed in a virus yield assay. Cidofovir [HPMPC; (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine] and its cyclic counterpart emerged as the most selective antipolyomavirus agents. The 50% inhibitory concentrations for HPMPC were in the range of 4 to 7 micrograms/ml, and its selectivity index varied from 11 to 20 for mouse polyomavirus and from 23 to 33 for SV40 strains in confluent cell monolayers. Cell cytotoxicity was up to 15-fold greater in growing cells. Other acyclic nucleoside phosphonates (i.e., HPMPA; [(S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine] and PMEG [9-(2-phosphonylmethoxyethyl)-guanine]) also showed some activity but had low selectivity. None of the other drugs tested against these animal viruses (i.e., acyclovir, ganciclovir, brivudine, ribavirin, foscarnet, and cytarabine) showed significant activity. Thus, HPMPC deserves further evaluation as a candidate drug for polyomavirus infections in the immunocompromised host.
Opportunistic computing in GPU architectures (2019)

Data transfer overhead between computing cores and memory hierarchy has been a persistent issue for von Neumann architectures and the problem has only become more challenging with the emergence of manycore systems. A conceptually powerful approach to mitigate this overhead is to bring the computation closer to data, known as Near Data Computing (NDC). Recently, NDC has been investigated in different flavors for CPU-based multicores, while the GPU domain has received little attention. In this paper, we present a novel NDC solution for GPU architectures with the objective of minimizing on-chip data transfer between the computing cores and Last-Level Cache (LLC). To achieve this, we first identify frequently occurring Load-Compute-Store instruction chains in GPU applications. These chains, when offloaded to a compute unit closer to where the data resides, can significantly reduce data movement. We develop two offloading techniques, called LLC-Compute and Omni-Compute. The first technique, LLC-Compute, augments the LLCs with computational hardware for handling the computation offloaded to them. The second technique (Omni-Compute) employs simple bookkeeping hardware to enable GPU cores to compute instructions offloaded by other GPU cores. Our experimental evaluations on nine GPGPU workloads indicate that the LLC-Compute technique provides, on an average, 19% performance improvement (IPC), 11% performance/watt improvement, and 29% reduction in on-chip data movement compared to the baseline GPU design. The Omni-Compute design boosts these benefits to 31%, 16% and 44%, respectively.
Spontaneous Formation of Nanoparticle Vesicles from Homopolymer Polyelectrolytes (2003)

Nanoparticle vesicles were spontaneously assembled from homopolymer polyamine polyelectrolytes and water-soluble, citrate-stabilized quantum dots. The further addition of silica nanoparticles to a solution of quantum dot vesicles generated stable micrometer-sized hollow spheres whose walls were formed of a thick, inner layer of close-packed quantum dots followed by an outer layer of silica. The method employed here to assemble both the nanoparticle vesicles and the hollow spheres is in direct contrast to previous syntheses that use either tailored block copolymers or oil-in-water emulsion templating. We propose that the formation of charge-stabilized hydrogen bonds between the positively charged amines of the homopolymer polyelectrolytes and the negatively charged citrate molecules stabilizing the quantum dots is responsible for the macroscopic phase separation in this completely aqueous system. The ease and processibility of the present approach gives promise for the production of a diverse array of materials ranging in applications from drug delivery to catalysis to micrometer-scale optical devices.
Application of Enzymes in the Pulp and Paper Industry (1999)

The pulp and paper industry processes huge quantities of lignocellulosic biomass every year. The technology for pulp manufacture is highly diverse, and numerous opportunities exist for the application of microbial enzymes. Historically, enzymes have found some uses in the paper industry, but these have been mainly confined to areas such as modifications of raw starch. However, a wide range of applications in the pulp and paper industry have now been identified. The use of enzymes in the pulp and paper industry has grown rapidly since the mid 1980s. While many applications of enzymes in the pulp and paper industry are still in the research and development stage, several applications have found their way into the mills in an unprecedented short period of time. Currently the most important application of enzymes is in the prebleaching of kraft pulp. Xylanase enzymes have been found to be most effective for that purpose. Xylanase prebleaching technology is now in use at several mills worldwide. This technology has been successfully transferred to full industrial scale in just a few years. The enzymatic pitch control method using lipase was put into practice in a large-scale paper-making process as a routine operation in the early 1990s and was the first case in the world in which an enzyme was successfully applied in the actual paper-making process. Improvement of pulp drainage with enzymes is practiced routinely at mill scale. Enzymatic deinking has also been successfully applied during mill trials and can be expected to expand in application as increasing amounts of newsprint must be deinked and recycled. The University of Georgia has recently opened a pilot plant for deinking of recycled paper. Pulp bleaching with a laccase mediator system has reached pilot plant stage and is expected to be commercialized soon. Enzymatic debarking, enzymatic beating, and reduction of vessel picking with enzymes are still in the R&D stage but hold great promise for reducing energy. Other enzymatic applications, i.e., removal of shives and slime, retting of flax fibers, and selective removal of xylan, are also expected to have a profound impact on the future technology of the pulp and paper-making process.
(+)-1-(3S,4R)-[3-(4-Phenylbenzyl)-4- hydroxychroman-7-yl]cyclopentane Carboxylic Acid, a Highly Potent, Selective Leukotriene B4 Antagonist with Oral Activity in the Murine Collagen-Induced Arthritis Model (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT(+)-1-(3S,4R)-[3-(4-Phenylbenzyl)-4- hydroxychroman-7-yl]cyclopentane Carboxylic Acid, a Highly Potent, Selective Leukotriene B4 Antagonist with Oral Activity in the Murine Collagen-Induced Arthritis ModelKevin Koch, Lawrence S. Melvin Jr., Lawrence A. Reiter, Michael S. Biggers, Henry J. Showell, Richard J. Griffiths, E. Roy Pettipher, John B. Cheng, Anthony J. Milici, and Cite this: J. Med. Chem. 1994, 37, 20, 3197–3199Publication Date (Print):September 1, 1994Publication History Published online1 May 2002Published inissue 1 September 1994https://pubs.acs.org/doi/10.1021/jm00046a001https://doi.org/10.1021/jm00046a001research-articleACS PublicationsRequest reuse permissionsArticle Views393Altmetric-Citations44LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Alkyl Chain Length Dependence of Field-Effect Mobilities in Regioregular Poly(3-Alkylthiophene) Films (2000)

Carrier mobilities have been studied using the field effect in regioregular poly(3-alkylthiphene) (PAT, alkyl=butyl, hexyl, decyl, dodecyl and octadecyl) cast films at a field of around 10 4 V/cm. It was found that the carrier mobility of poly(3-butylthiophene) is 1.0×10 -2 cm 2 /V·s, which is the largest one to date in the polythiophene family and three to four orders of magnitude larger than that of poly(3-octadecylthiophene). This result indicates that the substituted alkyl chain plays the role of a barrier to carrier migration between π-conjugated main chains, and primarily determines the mobility. The residual carrier densities are 10 15 to 10 16 cm -3 for all PATs and slightly lower for PATs with shorter alkyl chains. The field-effect mobilities are nearly the same as the values estimated by the time-of-flight method.
The physiological disposition and cardiac effects of procaine amide. (1951)

Procaine amide, the amide analogue of procaine, is relatively stable in the body since it is not affected by the enzyme which catalyzes the rapid hydrolysis of procaine. It is rapidly and completely absorbed from the gastrointestinal tract. Plasma levels in man decline only 10 to 20 per cent per hour. Metabolic transformation accounts for part of the decrease but urinary excretion accounts for the larger part. Organ tissues reversibly localize considerable amounts of the drug which are released to the plasma as the drug is lost by metabolic transformation or urinary excretion.

Procaine amide is an effective agent against ventricular arrhythmias. It protects dogs from arrhythmias produced by epinephrine during cyclopropane anesthesia. It suppresses ventricular premature contractions for variable periods in conscious humans. By means of the drug, sustained attacks of ventricular tachycardia have been successfully terminated in thirteen of fifteen patients.

The drug does not usually revert the arrhythmia in chronic auricular flutter and fibrillation but merely slows the auricular rate.

The drug is relatively non-toxic. On intravenous administration in therapeutic dosage, it does not cause the central nervous system stimulation typical of procaine in conscious subjects. With intravenous administration there may be a moderate, though transient, hypotension. In some cases of prolonged ventricular tachycardia where the arterial pressure is low, procaine amide causes a further fall, which disappears promptly with the termination of the tachycardia. Untoward effects have not been seen with daily oral dosage maintained up to three months.

Procaine amide seems more effective and less toxic than quinidine for the treatment of ventricular arrhythmias.