gebhart/patrepeval huggingface dataset:
Transient rRNA synthesis inhibition with CX-5461 is sufficient to elicit growth arrest and cell death in acute lymphoblastic leukemia cells (2015)

Enhanced rRNA synthesis is a downstream effect of many of the signaling pathways that are aberrantly activated in cancer, such as the PI3K/mTOR and MAP kinase pathways. Recently, two new rRNA synthesis inhibitors have demonstrated therapeutic effects on cancer cells while sparing normal cells. One of them, CX-5461, is currently in phase 1 clinical trials for hematological malignancies. Here, we investigate the effectiveness of transient treatment with this drug on acute lymphoblastic leukemia cells. Our results show that short exposure to CX-5461 followed by drug washout is sufficient to induce persistent G2 cell-cycle arrest and irreversible commitment to cell death, in spite of rRNA synthesis returning to normal within 24 hours of drug washout. The magnitude of cell death after transient exposure is similar to continuous exposure, but the time to cell death is relatively delayed with transient exposure. In this report, we also investigate rational drug combinations that can potentiate the effect of continuous CX-5461 treatment. We show that the checkpoint abrogator UCN-01 can relieve CX-5461-induced G2 arrest and potentiate the cytotoxic effects of CX-5461. Finally, we show that ERK1/2 is activated upon CX-5461 treatment, and that pharmacological inhibition of MEK1/2 leads to enhanced cell death in combination with CX-5461. In summary, our results provide evidence for the effectiveness of CX-5461 pulse treatment, which may minimize drug related toxicity, and evidence for enhanced effectiveness of CX-5461 in combination with other targeted agents.
Preliminary Study of the Catalytic Combustor Concept as Applied to Aircraft Gas Turbines (1974)

A catalytic combustor operating at low-equivalence ratios throughout was evaluated in terms of combustion efficiency and exhaust emissions using JP-4-fueled aircraft gas turbines. Measured nitrogen oxide concentrations were below 2 ppM (two orders of magnitude below that expected from conventional combustors) for all operating conditions tested. A definite trend of increasing NOx levels was noted for increasing exhaust temperatures, though the levels were still below the 2 ppM concentration. Virtually 100 percent combustion efficiency was obtained at combustor inlet temperatures above 700 F and fuel-air ratios above 0.02. Specific heat release rates of 3.5 million BTU/atm-hr-cu ft were achieved with high efficiency. Catalytic bed pressure drops were about 1 percent of the combustor static pressure at 44 ft/sec reference velocity and 2400 F exhaust temperature. Carbon monoxide and hydrocarbon emissions sharply increased at fuel-air ratios less than 0.0212 or exhaust temperatures less than 2000 F.
Photochemical reactions involved in the total mineralization of 2,4-D by iron(3+)/hydrogen peroxide/UV (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotochemical reactions involved in the total mineralization of 2,4-D by iron(3+)/hydrogen peroxide/UVYunfu Sun and Joseph J. PignatelloCite this: Environ. Sci. Technol. 1993, 27, 2, 304–310Publication Date (Print):February 1, 1993Publication History Published online1 May 2002Published inissue 1 February 1993https://pubs.acs.org/doi/10.1021/es00039a010https://doi.org/10.1021/es00039a010research-articleACS PublicationsRequest reuse permissionsArticle Views1858Altmetric-Citations493LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Autonomous control of distributed generation and storage to coordinate P/Q sharing in islanded microgrids - An approach beyond droop control (2014)

In this paper, a decentralized control for coordinate both active and reactive powers is proposed for islanded microgrids. Compared with the conventional droop control strategies, the proposed control realizes decentralized power distribution among renewable energy sources (RES) and energy storage systems (ESS) according to the local source conditions. Based on bus-signaling method, the ESS is able to limit charging power by decreasing RES power generation automatically. As well, the reactive power coordinated control makes the RES units able to support reactive power in a decentralized way, which allows ESS providing for more active power availability. Moreover, the reactive power is distributed according to the apparent power capacity of each unit. The control strategy principle is simple and easy to implement without extra communication requirements. Real time hardware-in-the-loop results are presented to show the feasibility of proposed control strategy.
The Mentally Ill Homeless: Isolation and Adaptation (1984)

Project HELP was established in New York City in 1982 as a mobile outreach unit providing crisis medical and psychiatric services to impaired homeless persons. The authors describe the demographic characteristics of the population served, the disposition of patients accepting treatment or shelter services, and the adaptation of the homeless to weather extremes. They discuss the difficulties in providing services to a population whose members are distrustful of authority and are unwilling to provide information about themselves. They conclude that the more disaffiliated members of the homeless population, such as those served by Project HELP, need even more extensive services than the homeless who use some kind of existing sheltered care, and they suggest various kinds of services to meet their needs.
Development of a Compact Centrifugal Pump With a Two-Axis Actively Positioned Consequent-Pole Bearingless Motor (2013)

A novel centrifugal pump has been developed that employs a bearingless motor with two-axis radial active positioning control. The structure of this motor is an extension of a hybrid of consequent-pole and homopolar-type bearingless motors. Based on 3-D finite-element-method analysis, the influence of the permanent-magnet dimension and motor current on magnetic suspension characteristics has been investigated. The passive stiffness of this motor has been enhanced. The test pump was fabricated and found to provide a maximum pump output of 1 W with a flow rate of 4 L/min against a head pressure of water of 1.5 m. An impeller with a shroud contributes to a significant reduction in axial impeller movement caused by axial thrust. The rotor vibration is significantly smaller than the fluid gaps in the pump casing. The experimental results demonstrate that the proposed consequent-pole bearingless motor is feasible and effective for use with a centrifugal pump.
Fully packaged, broad-band LiNbO<sub>3</sub> modulator with low drive voltage (2000)

A low drive voltage of /spl sim/5 V at 40 GHz has been achieved in a fully packaged, broad-band LiNbO/sub 3/ modulator. The excellent response is attributed to nearly perfect velocity and impedance matching, along with very long electrodes (41 mm), low electrode losses, and minimal packaging effects. Very accurate frequency-dependent drive voltages are obtained by the use of independent sets of measurements.
The effect of probiotics on gut flora, level of endotoxin and Child–Pugh score in cirrhotic patients: results of a double-blind randomized study (2007)

E. coli Nissle seems to be effective in the restoration of normal colonic colonization and can probably lower endotoxemia in cirrhotic patients.
Multitask Learning for Fine-Grained Twitter Sentiment Analysis (2017)

Traditional sentiment analysis approaches tackle problems like ternary (3-category) and fine-grained (5-category) classification by learning the tasks separately. We argue that such classification tasks are correlated and we propose a multitask approach based on a recurrent neural network that benefits by jointly learning them. Our study demonstrates the potential of multitask models on this type of problems and improves the state-of-the-art results in the fine-grained sentiment classification problem.
In vitro perfusion studies of human resistance artery function in essential hypertension. (1994)

To simulate in vivo conditions as closely as possible to in vitro conditions, we examined the morphological and functional characteristics of isolated human subcutaneous small arteries from 17 essential hypertensive patients and 14 normotensive control subjects using a perfusion myograph. Vessel segments were cannulated and exposed to conditions of constant flow and pressure. The ratio of media thickness to lumen diameter in arteries from hypertensive patients increased significantly. With the endothelium intact, sensitivity to extraluminally applied norepinephrine was not different, and this was not affected by inhibition of neuronal amine uptake with cocaine. After removal of the endothelium, sensitivity to norepinephrine was augmented in normotensive vessels to a greater extent than in hypertensive vessels. Endothelium-dependent relaxation to acetylcholine was significantly reduced in arteries from hypertensive patients, but endothelium-independent relaxation to sodium nitroprusside was not different from that observed in vessels from normotensive control subjects. These data demonstrate that sensitivity to exogenous norepinephrine is not different in essential hypertension but that there is defective endothelium-dependent dilatation, suggesting a contributory role for endothelium dysfunction in human essential hypertension.
Vector extensions to the VAX architecture (2002)

The extension of the VAX architecture to include integrated vector processing is discussed. The design goals and constraints and an overview of the resulting architecture are presented. The architecture maximizes the asynchronism between the scalar and vector processors and the parallelism within the vector processor. However, the design is consistent enough with the overall philosophy of the VAX architecture that only minimal changes to existing operating systems be required to support it.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
High‐Temperature Strength of Fluorine‐Doped Silicon Nitride (1994)

High‐purity Si 3 N 4 (with 2.5 wt% glassy SiO 2 ) doped with F was prepared by immersion of the starting powder into dilute HF and hot isostatic pressing without sintering additives, using a glass encapsulation method. Oxygen content and cation impurity content were almost the same for the F‐doped and undoped materials. However, X‐ray fluorescence analysis revealed the order of 100 ppm of F in the doped material, and a considerable amount of F was detected from the amorphous SiO 2 phase at grain‐boundary triple points by analytical transmission electron microscopy. High‐resolution electron microscopy found that an amorphous intergranular film was omnipresent in both of the materials, with an equilibrium thickness of 10 ± 1 å. Subcritical crack‐growth resistance and creep resistance at 1400°C were degraded significantly by the presence of F. Internal friction of doped materials exhibited a dear grain‐boundary relaxation peak, which suggested that F was present in the intergranular film at the two‐grain junctions; this decreased the grain‐boundary viscosity considerably. The film thickness of the doped material showed no apparent chemical effects and was explained by taking into account competing repulsive forces acting normal to the film.
Refraction corrected transmission ultrasound computed tomography for application in breast imaging (2010)

Purpose: We present an iterative framework for CT reconstruction from transmission ultrasound data which accurately and efficiently models the strong refraction effects that occur in our target application: Imaging the female breast. Methods: Our refractive ray tracing framework has its foundation in the fast marching method (FNMM) and it allows an accurate as well as efficient modeling of curved rays. We also describe a novel regularization scheme that yields further significant reconstruction quality improvements. A final contribution is the development of a realistic anthropomorphic digital breast phantom based on the NIH Visible Female data set. Results: Our system is able to resolve very fine details even in the presence of significant noise, and it reconstructs both sound speed and attenuation data. Excellent correspondence with a traditional, but significantly more computationally expensive wave equation solver is achieved. Conclusions: Apart from the accurate modeling of curved rays, decisive factors have also been our regularization scheme and the high‐quality interpolation filter we have used. An added benefit of our framework is that it accelerates well on GPUs where we have shown that clinical 3D reconstruction speeds on the order of minutes are possible.
Quantitative composition of volatile constituents in cultivated strawberries, <i>Fragaria ananassa</i> cv. senga sengana, senga litessa and senga gourmella (1980)

Abstract The volatile components of cultivated strawberries Fragaria ananassa cv. Senga Sengana, Senga Litessa and Senga Gourmella were studied by gas chromatography‐mass spectrometry. Employing standard‐controlled aroma separation by combined vacuum distillation‐liquid‐liquid extraction, as well as prefractionation on silica gel, the aroma substances of freshly harvested and deep‐frozen strawberries from two growing seasons were quantitatively determined by gas chromatography. Methyl and ethyl butanoate, methyl and ethyl hexanoate, trans ‐2‐hexenyl acetate, trans ‐2‐hexenal, trans ‐2‐hexen‐1‐ol as well as 2,5‐dimethyl‐4‐methoxy‐3(2H)‐furanone were identified as main volatile components. In comparison to Senga Litessa and Senga Gourmella, Senga Sengana showed higher amounts of aroma compounds. In general, deep‐freezing resulted in decreases of the concentrations of most of the aroma substances, but higher amounts of 2,5‐dimethyl‐4‐methoxy‐3(2H)‐furanone were found in deep‐frozen berries than in the freshly harvested ones.
Application of Time Series Analysis to Predict Reservoir Production Performance (2014)

Abstract Decline curve analysis (DCA), material balance (MB) and numerical simulation are used to predict reservoir performance. However, these methods have peculiar strengths and limitations. While some are based on analytical observations and theories others are purely stochastic. The objective of this study was to investigate the applicability of Time Series analysis to predict oil cumulative production as a measure of reservoir performance. The Box Jenkins method of Time Series analysis utilizing the Autoregressive Integrated Moving Average (ARIMA) models was used to predict and analyse oil cumulative production of wells and reservoirs. The process involves a robust transformation of production datasets into time series. A best fitting model was chosen using maximum absolute deviations as a measure of fit. Predictions of the ARIMA model were validated with historical data and its performance was compared with Decline Curve analysis (DCA).The coefficient of each model was optimized using the simplex optimization technique. The results show that ARIMA (1,1,0) model gives the best match with actual cumulative oil production data. The model had the least maximum deviation of 4.24% compared to 178.95%, 182.32% and 24.45% for ARIMA (1,0,0), ARIMA (2,0,0) AND ARIMA (1,2,0) respectively after predicting for 900 days. Analysis of results after 1097 days of production also shows that the ARIMA (1,1,0) predicts better than the DCA method. The maximum deviation for both ARIMA and DCA were 1.81% and 12.79% respectively. The best model coefficients fall between 1.99 and 1.9999999. A model coefficient too high or too low will definitely lead to erroneous predictions. This study has shown that ARIMA (1,1,0) can be used to model and predict reservoir/well cumulative oil production accurately for short to mid-long term periods. Furthermore, the model performs better than the DCA for medium to mid-long term predictions. The accuracy of the model can be improved as more data become available for history matching to further refine the model coefficients. A model coefficient of 1.995 is recommended when few data are available.
1 GHz HAL SPARC64/sup R/ Dual Floating Point Unit with RAS features (2002)

An IEEE compliant, 1 GHz Sparc64-V Floating-Point Unit (FPU) with reliability-accessibility-serviceability (RAS) features and partial support for denormal operands and results is presented. The FPU has two functional units, each with an adder (FADD) and a multiplier (FMUL). Additionally, one of the functional units contains a graphics unit (VIS). Two floating-point instructions can be scheduled out of order each cycle, one to each functional unit. A peak performance of 4 GFLOP is achieved by scheduling two floating-point multiply add (FMA) instructions each cycle. The FADD unit is fully pipelined and can execute an addition, subtraction, conversion, or compare instruction every cycle. The FMUL unit executes pipelined multiply instructions. Divide and square-root instructions are executed with multiple iterations through the multiplier pipeline. The VIS unit is also pipelined and executes SIMD fixed-point graphics instructions. The adder and multiplier have latencies of 3 and 4 cycles respectively. Novel techniques are presented in the adder and multiplier implementations to reduce area and cycle time. The FPU provides RAS support for enhanced server reliability by using selective parity error detection. The FPU has been implemented in 0.15 u, 6-layer metal CMOS technology.
Bromoenol Lactone Inhibits Magnesium-dependent Phosphatidate Phosphohydrolase and Blocks Triacylglycerol Biosynthesis in Mouse P388D1 Macrophages (1996)

Bromoenol lactone (BEL) has previously been identified as a potent, irreversible, mechanism-based phospholipase A2 (PLA2) inhibitor that possesses greater than 1000-fold selectivity for inhibition of Ca2+-independent PLA2 (iPLA2) versus the Ca2+-dependent ones. Thus, this compound has been used as a selective tool for studies aimed at elucidating the role of iPLA2 in certain cellular functions. Herein we report that BEL also inhibits cellular phosphatidic acid phosphohydrolase (PAP) activity in intact P388D1 macrophages with an IC50 of about 8 microM, which is very similar to that previously found for inhibition of iPLA2 under the same experimental conditions. This results in the blockage of the incorporation of exogenous arachidonate and palmitate into diacylglycerol and triacylglycerol. Thus, inhibition of PAP by BEL blocks triacylglycerol biosynthesis in P388D1 cells due to decreased diacylglycerol availability. Because two forms of PAP activity exist in mammalian cells, differential assays were performed to identify which of these forms was inhibited by BEL. The results of these experiments revealed that BEL selectively inhibits the cytosolic, Mg2+-dependent enzyme. No apparent effect of BEL on the membrane-bound Mg2+-independent PAP form could be detected. Collectively, the results reported herein establish that BEL inhibits two cellular phospholipases, namely iPLA2 and Mg2+-dependent PAP, with similar potency. Therefore, the inhibitory effect of BEL on Mg2+-dependent PAP might explain several cellular functions previously attributed to iPLA2.
Short RNAs Can Identify New Candidate Transposable Element Families in Arabidopsis (2002)

Mining the Arabidopsis genome for transposable elements (TEs) by DNA sequence similarity searches and analysis protocols is revealing previously unidentified families of TEs and providing insights into TE structure, mobility, distribution, and diversity ([Le et al., 2000][1]). We suggest here that
Antigens recognized by T-lymphocytes on human tumours (1997)

Conference Article| May 01 1997 Antigens recognized by T-lymphocytes on human tumours P. G. Coulie; P. G. Coulie * *To whom correspondence should be addressed. Search for other works by this author on: This Site PubMed Google Scholar B. J. Van den Eynde; B. J. Van den Eynde 1Cellular Genetics Unit, Université Catholique de Louvain, Brussels, Belgium and Ludwig Institute for Cancer Research, B1200 Brussels, Belgium Search for other works by this author on: This Site PubMed Google Scholar P. van der Bruggen; P. van der Bruggen 1Cellular Genetics Unit, Université Catholique de Louvain, Brussels, Belgium and Ludwig Institute for Cancer Research, B1200 Brussels, Belgium Search for other works by this author on: This Site PubMed Google Scholar A. Van Pel; A. Van Pel 1Cellular Genetics Unit, Université Catholique de Louvain, Brussels, Belgium and Ludwig Institute for Cancer Research, B1200 Brussels, Belgium Search for other works by this author on: This Site PubMed Google Scholar T. Boon T. Boon 1Cellular Genetics Unit, Université Catholique de Louvain, Brussels, Belgium and Ludwig Institute for Cancer Research, B1200 Brussels, Belgium Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1997) 25 (2): 544–548. https://doi.org/10.1042/bst0250544 Article history Received: October 29 1996 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation P. G. Coulie, B. J. Van den Eynde, P. van der Bruggen, A. Van Pel, T. Boon; Antigens recognized by T-lymphocytes on human tumours. Biochem Soc Trans 1 May 1997; 25 (2): 544–548. doi: https://doi.org/10.1042/bst0250544 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: CTL, cytolytic T-lymphocyte © 1997 Biochemical Society1997 Article PDF first page preview Close Modal You do not currently have access to this content.
[Hemodynamics, hemocoagulation and neuroendocrine responses in long-duration anesthesia. Comparison of propofol infusion with thiopentone and NLA II]. (1991)

Ten patients receiving propofol for the induction and maintenance of anaesthesia were compared with 10 patients in whom anaesthesia was induced with thyopentone and maintained with fentanil. The cardiovascular response to anaesthesia, the effects on coagulation and fibrinolysis and the neuroendocrine response have been investigated during surgical procedures exceeding 90'. There was a larger decrease in PA after induction in the propofol group versus control, but the overall quality of anaesthesia during induction and maintenance was comparable in both groups. No differences were found about blood coagulation and fibrinolysis between the groups. Important differences between the groups were instead found about the cortisol response to anaesthesia and surgery: in the propofol group there was a decrease in the cortisol concentration in 90' sample with no statistical significance, returning to the baseline value after 1 h from recovery. In the control group a significant increase of cortisol concentration was noted both at 90' and 1 h after the end of anaesthesia.