gebhart/patrepeval huggingface dataset:
Estrogenic and antiestrogenic properties of resveratrol in mammary tumor models. (2001)

Trans-3,4',5-trihydroxystilbene (resveratrol), a phytoalexin present in grapes and grape products such as wine, has been identified as a chemopreventive agent. Recent studies performed with MCF-7 human breast cancer cells have demonstrated superestrogenic effects with resveratrol. In contrast, studies performed using estrogen receptor-transfected cell lines have shown that resveratrol acts as a mixed agonist/antagonist. The major objective of this study was to characterize the estrogen-modulatory effects of resveratrol in a variety of in vitro and in vivo mammary models. Thus, the effect of resveratrol alone and in combination with 17beta-estradiol (E2) was assessed with MCF-7, T47D, LY2, and S30 mammary cancer cell lines. With cells transfected with reporter gene systems, the activation of estrogen response element-luciferase was studied, and using Western blot analysis, the expression of E2-responsive progesterone receptor (PR) and presnelin 2 protein was monitored. Furthermore, the effect of resveratrol on formation of preneoplastic lesions (induced by 7,12-dimethylbenz(a)anthracene) and PR expression (with or without E2) was evaluated with mammary glands of BALB/c mice placed in organ culture. Finally, the effect of p.o. administered resveratrol on N-methyl-N-nitrosourea-induced mammary tumors was studied in female Sprague Dawley rats. As a result, in transient transfection studies with MCF-7 cells, resveratrol showed a weak estrogenic response, but when resveratrol was combined with E2 (1 nM), a clear dose-dependent antagonism was observed. Similar mixed estrogenic/antiestrogenic effects were noted with S30 cells, whereas resveratrol functioned as a pure estrogen antagonist with T47D and LY2 cells. Furthermore, in MCF-7 cells, resveratrol induced PR protein expression, but when resveratrol was combined with E2, expression of PR was suppressed. With T47D cells, resveratrol significantly down-regulated steady-state and E2-induced protein levels of PR. With LY2 and S30 cells, resveratrol down-regulated presnelin 2 protein expression. Using the mouse mammary organ culture model, resveratrol induced PR when administered alone, but expression was suppressed in the presence of E2 (1 nM). Furthermore, resveratrol inhibited the formation of estrogen-dependent preneoplastic ductal lesions induced by 7,12-dimethylbenz(a)anthracene in these mammary glands (IC50 = 3.2 microM) and reduced N-methyl-N-nitrosourea-induced mammary tumorigenesis when administered to female Sprague Dawley rats by gavage. Therefore, in the absence of E2, resveratrol exerts mixed estrogen agonist/antagonist activities in some mammary cancer cell lines, but in the presence of E2, resveratrol functions as an antiestrogen. In rodent models, carcinogen-induced preneoplastic lesions and mammary tumors are inhibited. These data suggest that resveratrol may have beneficial effects if used as a chemopreventive agent for breast cancer.
Rho Kinase Inhibitor Y-27632 Prolongs the Life Span of Adult Human Keratinocytes, Enhances Skin Equivalent Development, and Facilitates Lentiviral Transduction (2012)

The use of tissue-engineered human skin equivalents (HSE) for fundamental research and industrial application requires the expansion of keratinocytes from a limited number of skin biopsies donated by adult healthy volunteers or patients. A pharmacological inhibitor of Rho-associated protein kinases, Y-27632, was recently reported to immortalize neonatal human foreskin keratinocytes. Here, we investigated the potential use of Y-27632 to expand human adult keratinocytes and evaluated its effects on HSE development and in vitro gene delivery assays. Y-27632 was found to significantly increase the life span of human adult keratinocytes (up to five to eight passages). The epidermal morphology of HSEs generated from high-passage, Y-27632-treated keratinocytes resembled the native epidermis and was improved by supplementing Y-27632 during the submerged phase of HSE development. In addition, Y-27632-treated keratinocytes responded normally to inflammatory stimuli, and could be used to generate HSEs with a psoriatic phenotype, upon stimulation with relevant cytokines. Furthermore, Y-27632 significantly enhanced both lentiviral transduction efficiency of primary adult keratinocytes and epidermal morphology of HSEs generated thereof. Our study indicates that Y-27632 is a potentially powerful tool that is used for a variety of applications of adult human keratinocytes.
An Automatic Labeling of K-means Clusters based on Chi-Square Value (2017)

Automatic labeling methods in text clustering are widely implemented. However, there are limited studies in automatic cluster labeling for numeric data points. Therefore, the aim of this study is to develop a novel automatic cluster labeling of numeric data points that utilize analysis of Chi-Square test as its cluster label. We performed K-means clustering as a clustering method and disparity of Health Human Resources as a case study. The result shows that the accuracy of cluster labeling is about 89.14%.
Mate Preference and Mating Behavior of Male <I>Helicoverpa zea</I> (Lepidoptera: Noctuidae) Infected with the Sexually Transmitted Insect Virus Hz-2V (2006)

The affect of Hz-2V (a.k.a. gonad-specic virus) virus infection on the reproductive physiology and behavior of infected adult Helicoverpa zea (Boddie) (Lepidoptera: Noctuidae) males was examined. Virus-infected males responded and ew to calling healthy and infected females at about the same rate. Although infected males were slower in approaching healthy females and attempting to mate compared with healthy males, infected males did make sexual contacts with females that could serve to transmit virus. Unlike matings with healthy males, which result in the cessation of calling, females that had made sexual contact with infected males continued to exhibit calling behavior and were receptive to mates. Although calling behavior of both healthy and infected females was inhibited by injecting extracts of reproductive tissues from healthy males, extracts of reproductive tissues from infected males inhibited female calling to a lesser degree and for an additional night compared with extracts from healthy males. The results presented here further demonstrate the ability of Hz-2V to alter the physiology and behavior of infected insects in ways that could serve to facilitate virus transmission.
Hypothalamic amenorrhea with normal body weight: ACTH, allopregnanolone and cortisol responses to corticotropin-releasing hormone test (2000)

In conclusion, women with HA, despite the high ACTH and cortisol levels and, therefore, hypothalamus-pituitary-adrenal axis hyperactivity, are characterized by low allopregnanolone basal levels, deriving from an impairment of both adrenal and ovarian synthesis. The blunted ACTH, allopregnanolone and cortisol responses to CRH indicate that, in hypothalamic amenorrhea, there is a reduced sensitivity and expression of CRH receptor. These results open new perspectives on the role of neurosteroids in the pathogenesis of hypothalamic amenorrhea.
fedTV: personal networks federation for IdM in mobile DTV (2011)

Mobile Social TV and Mobile Video Blogging are new challenging scenarios arising from mobile and online DTV. They will allow for new interactions, and dynamically share content and delegate services. That requires the dynamic discovery, joining, and establishing new federations, emerging the trust management as an important facet for that. Such trust management should be autonomous, user-centric, and dynamic to cope with forthcoming applications. We propose an enhanced mobile client to support federated environments for cooperation in mobile DTV scenarios. Our proposal extends the Enhanced Client Profile defined in SAML v2, incorporating a trust management layer inside user's consumer electronic devices' software.
Mergers Sweep Fertilizer Sector (2015)

RETURN TO ISSUEPREVNewsNEXTMergers Sweep Fertilizer SectorCite this: Chem. Eng. News 2015, 93, 32, 6Publication Date (Print):August 17, 2015Publication History Published online30 March 2016Published inissue 17 August 2015https://pubs.acs.org/doi/10.1021/cen-09332-notw5https://doi.org/10.1021/cen-09332-notw5newsACS PublicationsCopyright © 2015 Chemical & Engineering NewsArticle Views2Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options SUBJECTS:Manufacturing,Nitrogen Get e-Alerts
Infinitely Many Sign-changing Solutions for a p-Laplacian Equation in R(superscript N) (2010)

In this paper, we study a p-Laplacian elliptic equation-△(subscript p)u+|u|(superscript (p-2))u=f(x, u) in R(superscript N), u∈ W^1, p(R(superscript N))(P≠2). Applying Principle of Symmetric Criticality and the invariant set method, we obtain infinitely many radial sign-changing solutions for the above equation under some assumptions on f. Besides, using the symmetric Mountain Pass Theorem and Principle of Symmetric Criticality, we also obtain infinitely many nonradial sign-changing solutions for the above equation when N=4 or N≥6.
Fluxos videomusicais: uma proposta epistemológica para o estudo dos vídeos musicais na web 2.0 (2010)

Este artigo aborda as profundas altera&ccedil;&otilde;es sofridas pelos v&iacute;deos musicais na sua converg&ecirc;ncia digital de um produto televisivo para um dos conte&uacute;dos mais populares da web 2.0 e prop&otilde;e igualmente uma abordagem epistemol&oacute;gica para o seu estudo nas plataformas digitais. Os elementos basilares do modelo te&oacute;rico s&atilde;o os media studies 2.0, a interdisciplinaridade com os estudos liter&aacute;rios, a cultura participativa e a intelig&ecirc;ncia colectiva. Palavras-Chave: V&iacute;deos Musicais, Web 2.0, Cultura Participativa, Intelig&ecirc;ncia Colectiva Abstract This paper focuses on the profound transformations occurred in the music video format during its ongoing digital convergence from a TV product to one of the most popular web 2.0 contents and proposes an epistemic method for its analysis. The theoretical model is based on the media studies 2.0, an interdisciplinary approach with literary studies and key-concepts such as participatory culture and collective intelligence. Keywords: Music Videos, Web 2.0, Participatory Culture, Collective Intelligence
Functional and metabolic properties of human asialofibrinogen. (1977)

The role of sialic acid in the functional and metabolic properties of purified human fibrinogen was investigated. Fibrinogen treated with Vibrio cholerae neuraminidase released 90 percent of its sialic acid without evidence of proteolysis, as indicated by the presence of intace A alpha, B beta, and gamma chains on sodium dodecylsulfate (SDS)-polyacrylamide gels of the reduced asialoprotein. The thrombin and Reptilase clotting times of human asialofibrinogen were shortened compared to those of normal fibrinogen. Fibrinopeptide release was normal in rate and amount, but asialofibrin monomer aggregation was increased at both low and high ionic strength. Similarly, the asialo-derivative of fibrinogen Philadelphia (functionally characterized by impairment of fibrin monomer aggregation) demonstrated shortening of its thrombin and Reptilase times and improvement in its monomer aggregation especially at high ionic strength. Asialofibrin showed a normal capacity to form cross-linked fibrin as demonstrated by normal gamma-chain dimerization and alpha-chain polymerization. Simultaneous metabolic studies of human normal fibrinogen and asialofibrinogen in rabbits revealed only a modest decrease in the half-life of the asialoprotein compared to the intact protein, with no preferential uptake of the asialo-derivative by the liver. Control studies with rabbit normal fibrinogen and asialofibrinogen in rabbits revealed the same modest difference in half-life. Thus, asialofibrinogen clots faster due to enhancement of its monomer aggregation, has a normal capacity to form cross-linked fibrin, and does not differ significantly in its metabolic properties from normal fibrinogen. The possible influence of sialic acid in the functional abnormality of some congenital dysfibrinogenemias is discussed.
Acute interaction of vasopressin and neurogenic mechanisms in DOC-salt hypertension (1982)

We investigated the relative role of vasopressin and neurogenic factors in the control of vascular resistance in rats treated with desoxycorticosterone (DOC) and salt and in control rats. DOC-salt-treated rats had elevated hindquarter vascular resistance (P less than 0.05). Vasopressin and neurogenic tone contributed significantly (P less than 0.05) to increased resistance. Vasodilator responses to a specific vasopressin antagonist, I-deaminopenicillamine, 4-valine, 8-D-arginine vasopressin (dPVDAVP), and lumbar sympathectomy in separate DOC-salt groups accounted for 40 +/- 5 (SE) and 43 +/- 6%, respectively, of the total vasodilator capacity. In contrast, corresponding responses to dPVDAVP and lumbar sympathectomy in control rats were smaller (P less than 0.01), were significantly different (P less than 0.05), and accounted for 8 +/- 3 and 20 +/- 3%, respectively, of the total vasodilator capacity. Effects of dPVDAVP compared in innervated hindquarters of DOC-salt-treated and control rats were greater in DOC-salt-treated rats (P less than 0.001); in the denervated hindquarters the effects of dPVDAVP were similar in DOC-salt-treated and control rats. Therefore, effects of vasopressin on vascular resistance were augmented in DOC-salt-treated hypertensive rats; furthermore this augmented effect was dependent on an intact innervation.
NMR and magnetization studies of Co/Cu superlattices (1991)

Co NMR and magnetization have been measured in a series of Co/Cu superlattices grown by molecular-beam epitaxy, with Co thicknesses varying from 5 to 100 \AA{}. The Co structure is mainly fcc for thicknesses of up to 65 \AA{}. For thicker Co layers the structure becomes hcp. For thin layers it is shown that the hyperfine field corresponding to fcc regions is nearly isotropic, whereas that arising from faulted (hcp) regions is anisotropic, with the symmetry axis parallel to the film normal. The anisotropic part of this field has the same sign and order of magnitude as in bulk hcp Co. For the sample with 5-\AA{} Co layers the dispersion of the magnetocrystalline anisotropy over the sample can be ascribed to Co-layer thicknesses which vary from 2 to 3 monolayers (4 to 6 \AA{}) throughout the sample.
An efficient reconfigurable architecture by characterizing most frequent logic functions (2015)

Generous flexibility of Look-Up Tables (LUTs) in implementing arbitrary functions comes with significant performance and area overheads compared with their Application-Specific Integrated Circuit (ASIC) equivalent. One approach to alleviate such overheads is to use less flexible logic elements capable to implement majority of logic functions. In this paper, we first investigate the most frequently used functions in standard benchmarks and then design a set of less-flexible but area-efficient logic cells, called Hard Logics (HL). Since higher input functions have diverse classes, we leverage Shannon decomposition to break them into smaller ones to either reduce the HL design space complexity or attain asymmetric low input functions. A heterogeneous LUT-HL architecture and a mapping scheme are also proposed to attain maximum logic resource usage. Experimental results on MCNC benchmarks demonstrate that the proposed architecture reduces area-delay product by 13% and 36% as compared to LUT4 and LUT6 based FPGAs, respectively. Considering the same area budget, our proposed architecture improves performance by 17% and 2% as compared to LUT4 and LUT6 based FPGAs.
CD8 T-cell Responses against Cyclin B1 in Breast Cancer Patients with Tumors Overexpressing p53 (2009)

Our data support the notion of cyclin B1 as a prominent target for immunologic recognition in cancer patients harboring p53-mutated cancer cells. Because mutation of p53 is one of the most frequent genetic alterations in human cancers, this suggests that immunotherapy based on targeting of cyclin B1 is broadly applicable in a large proportion of cancer patients.
New bit line architecture for ultra high speed SRAMs-T-shaped bit line and its real application to 256 k BiCMOS TTL SRAM (2002)

The authors propose a novel bit line architecture, the T-shaped bit line architecture (TSBA), which is suitable for high-speed, high-density and/or large bit-wide configuration SRAMs (static random-access memories). This architecture is applied to 256-kb BiCMOS TTL (transistor-transistor logic) I/O SRAM with a typical access time of 5.8 ns. To achieve sub-6-ns access time, a bipolar Darlington column sense amplifier, a global column decode technique, a shielded data bus technique with TSBA, and 0.8- mu m BiCMOS technology are employed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Assessment of the residual efficacy of lambda-cyhalothrin. 2. A comparison with DDT for the intradomiciliary control of Anopheles arabiensis in South Africa. (1993)

There are several factors that support the need to assess the efficacy of potential alternative insecticides to DDT for malaria vector control. The objectives of this study were to evaluate the persistence and efficacy against Anopheles arabiensis of lambda-cyhalothrin used as an intradomiciliary insecticide in daub huts and to compare its efficacy in this regard to DDT. Exit trap catches showed the population of An. arabiensis was high during the months of January to March, with a peak in February. During all months, the number caught leaving lambda-cyhalothrin-sprayed huts was markedly less than the number from both control and DDT-sprayed huts. The percentage survival of bloodfed mosquitoes ranged from a low of 55% caught leaving the lambda-cyhalothrin-sprayed huts, to 82% of those caught leaving DDT-sprayed huts. The percentage of bloodfed mosquitoes caught leaving huts was high (> 60%). The survival of unfed mosquitoes was low, even from the control huts (43%).
Salts on Europa's Surface Detected by Galileo's Near Infrared Mapping Spectrometer (1998)

Reflectance spectra in the 1- to 2.5-micrometer wavelength region of the surface of Europa obtained by Galileo's Near Infrared Mapping Spectrometer exhibit distorted water absorption bands that indicate the presence of hydrated minerals. The laboratory spectra of hydrated salt minerals such as magnesium sulfates and sodium carbonates and mixtures of these minerals provide a close match to the Europa spectra. The distorted bands are only observed in the optically darker areas of Europa, including the lineaments, and may represent evaporite deposits formed by water, rich in dissolved salts, reaching the surface from a water-rich layer underlying an ice crust.
What you seek is what you get: extraction of class attributes from query logs (2007)

Within the larger area of automatic acquisition of knowledge from the Web, we introduce a method for extracting relevant attributes, or quantifiable properties, for various classes of objects. The method extracts attributes such as capital city and President for the class Country, or cost, manufacturer and side effects for the class Drug, without relying on any expensive language resources or complex processing tools. In a departure from previous approaches to large-scale information extraction, we explore the role of Web query logs, rather than Web documents, as an alternative source of class attributes. The quality of the extracted attributes recommends query logs as a valuable, albeit little explored, resource for information extraction.
Fast Image Upsampling via the Displacement Field (2014)

In this paper, we present a fast image upsampling method within a two-scale framework to ensure the sharp construction of upsampled image for both large-scale edges and small-scale structures. In our approach, the low-frequency image is recovered via a novel sharpness preserving interpolation technique based on a well-constructed displacement field, which is estimated by a cross-resolution sharpness preserving model. Within this model, the distances of pixels on edges are preserved, which enables the recovery of sharp edges in the high-resolution result. Likewise, local high-frequency structures are reconstructed via a sharpness preserving reconstruction algorithm. Extensive experiments show that our method outperforms current state-of-the-art approaches, based on quantitative and qualitative evaluations, as well as perceptual evaluation by a user study. Moreover, our approach is very fast so as to be practical for real applications.
A 200 MHz CMOS Q-enhanced LC bandpass filter (1996)

This paper presents design techniques and performance bounds for implementing Q-enhanced, LC bandpass filters in silicon IC technologies. These filters offer significant advantages over switched capacitor and Gm-C based designs, including higher frequency of operation and lower power consumption for a given dynamic range. A prototype 200 MHz, fourth-order filter implemented in a 2 /spl mu/m n-well CMOS process is described, and measured performance is compared with theoretical predictions. The prototype filter operates at a selectivity Q of 100 and draws less than 8 mA when operating from 3 to 5 V supplies, making it potentially suitable for use as a first IF filter in modern cellular and PCS receivers.
The lived experiences of people with bladder cancer and their partners (2014)

Susan Heyes and colleagues review studies into the effects of bladder cancer diagnosis and treatment on personal relationships
Human gelatin tissue-adhesive hydrogels prepared by enzyme-mediated biosynthesis of DOPA and Fe<sup>3+</sup>ion crosslinking (2013)

Gelatin is extensively used as a biomaterial for diverse pharmaceutical and medical applications due to its excellent biocompatibility and biodegradability. Here we present bio-inspired tissue-adhesive gelatin hydrogels prepared by the enzyme-mediated synthesis of l-3,4-dihydroxyphenylalanine (l-DOPA) and Fe<sup>3+</sup> ion crosslinking. Gelatin of human origin was obtained through two major steps, extracellular matrix (ECM) extraction from human adipose tissue and gelatin isolation from the ECM. The tyrosine residues in human gelatin were converted into DOPA by enzymatic reaction with tyrosinase. Upon the addition of Fe<sup>3+</sup> ions, the DOPA-modified gelatin formed a sticky hydrogel within seconds through complexation between the DOPA molecules and Fe<sup>3+</sup> ions. The final DOPA-modified, Fe<sup>3+</sup> ion-crosslinked gelatin hydrogels retained their hydrogel stability well at body temperature in an aqueous environment and exhibited appropriate mechanical properties. The hemostatic ability of the DOPA-Fe<sup>3+</sup> gelatin hydrogels was explored using a hemorrhaging liver rat model. Shortly after the injection of the DOPA-Fe<sup>3+</sup> gelatin hydrogel, the bleeding was arrested in the hemorrhaging site of the liver. Overall results suggest that the DOPA-Fe<sup>3+</sup> gelatin hydrogel, with its good elastic and hemostatic properties, is a promising tissue adhesive for use in a wide variety of surgical operations.