gebhart/patrepeval huggingface dataset:
Amylo-1,6-glucosidase/4-alpha-glucanotransferase. Reaction of rabbit muscle debranching enzyme with an active site-directed irreversible inhibitor, 1-S-dimethylarsino-1-thio-beta-D-glucopyranoside. (1980)

Mammalian glycogen debranching enzyme, amylo-1,6-glucosidase/4-a-glucanotransferase, consists of a single polypeptide chain with two different active sites.Studies with reversible substrate model inhibitors have shown that the active sites share a common or overlapping polysaccharide binding site.To define further the reaction mechanism of this multicatalytic site enzyme, the effect of a new irreversible inhibitor has been studied.The inhibitor l-S-dimethylarsino-l-thio-8-D-glucanopyranoside (DATG) reacts with the debranching enzyme to inactivate both the glucosidase and the transferase activities.The two activities are lost at different rates.The rate of inactivation of each activity is first order in both enzyme and inhibitor concentration.Glucosidase and combined glucosidase-transferase activity are lost at the same rate, indicating that the glucosidase is rate-limiting for the combined action on glycogen phosphorylase limit dextrin.The relative rate of inactivation of the glucosidase and transferase activities by DATG is a function of the protein concentration.At high enzyme concentration (>6 mg/ml), the transferase is inactivated twice as rapidly as the glucosidase; at low enzyme concentration ( ~0 . 7mg/ml), the transferase is inactivated only one-half as fast.The rate of inactivation of both activities at high enzyme concentration is much slower, indicating that aggregation of the protein at these concentrations affects the accessibility of DATG to the active sites.The sites of DATG reaction with the debrancher were deduced from the protective effect of a series of substrates and substrate analogs.Glycogen phosphorylase limit dextrin protects both the glucosidase and transferase activities from inactivation by DATG.bis-"ris, (2,2-bis(hydroxy-methyI)-2,2',2"-nitrilotriethanol), a reversible inhibitor which binds specifically at the glucosidase active site, protects the glucosidase but not the transferase against inactivation.a-Schardinger dextrin, which binds to the polymer site, has no protective effect against the action of DATG.The results indicate that DATG acts as an active site-directed irreversible inhibitor at both the glucosidase and the transferase active sites on the de-
[Mechanisms of restenosis after coronary angioplasty]. (1996)

Coronary restenosis is the direct result of arterial trauma caused by angioplasty and therefore affects all patients to different degrees. Fracture of the plaque extending to the media is the principal mechanism of increase of the arterial lumen after balloon angioplasty, wall stretching concerning mainly excentric lesions. Atherectomy causes pulverisation of excision of the plaque without fracture. Stents reduce the amount of debris and the torn appearances of the plaque often observed after angioplasty. Four mechanisms are involved in the induction of restenosis: neointimal hyperplasia, proportional to the amount of trauma (damage to the internal elastic layer), related to proliferation of smooth muscle cells migrating from the media to the intima nad stimulated by many growth factors: defective remodelling or chronic elastic recoil, characterised by a reduction of the arterial lumen at the angioplasty site; acute elastic recoil in the first minutes or hours after angioplasty, mainly observed in excentric lesions; thrombosis, whose role is secondary except in certain clinical situations such as unstable angina, angioplasty of saphenous vein grafts or long dissections. The classical theories of restensosis attribute a major role to initial hyperplasia but more recent experimental and clinical data, obtained largely from endocoronary ultrasonography, suggest that defective remodelling may be more important. Although endocoronary stents prevent acute and chronic elastic recoil effectively, they do not prevent restenosis which remains a complex, multifactorial phenomenon.
Treatment of<i>Acinetobacter</i>infections (2010)

Pooled data suggest that infections caused by A. baumannii, especially those with inappropriate treatment, are associated with considerable attributable mortality. The optimal treatment for A. baumannii nosocomial infections has not been established, especially for MDR strains. Therefore, well-designed clinical studies are necessary to guide clinicians on decisions regarding the best therapeutic approach for patients with MDR A. baumannii infections. In addition, new experimental studies are warranted to evaluate the activity and safety of peptides and other novel antibacterial agents for A. baumannii infections.
Real-Time Measurement of Mental Workload Using Psychophysiological Measures (1990)

Abstract : The primary goal of the research was to explore the utility of event- related potentials (ERPs) as real-time measures of mental workload. Subjects performed a six-gauge monitoring task and a mental arithmetic task concurrently and at several difficulty levels. Difficulty was varied in terms of gauge predictability and by using two or three column arithmetic problems. A bootstrapping approach was adopted in which 1,000 samples of n trials (n=1,3,5,. ..65 single trials) were classified as to mental workload level using ERP measures (P300 and slow wave amplitude). Classification accuracies of 85 percent were achieved with 25 trials. Results are discussed in terms of potential enhancements for real-time recording of performance monitoring. Keywords: Mental workload, Event-related potentials, Real-time metrics.
First-principles calculations of the near-edge optical properties of β-Ga2O3 (2016)

We use first-principles calculations based on many-body perturbation theory to investigate the near-edge electronic and optical properties of β-Ga2O3. The fundamental band gap is indirect, but the minimum direct gap is only 29 meV higher in energy, which explains the strong near-edge absorption. Our calculations verify the anisotropy of the absorption onset and explain the range (4.4–5.0 eV) of experimentally reported band-gap values. Our results for the radiative recombination rate indicate that intrinsic light emission in the deep-ultra-violet (UV) range is possible in this indirect-gap semiconductor at high excitation. Our work demonstrates the applicability of β-Ga2O3 for deep-UV detection and emission.
Performance Requirements for the Coast Guard's Differential GPS Service (1993)

The United States Coast Guard is responsible for the design, procurement, installation, and operation of reference stations, broadcast facilities, monitor sites, and control stations to provide a Differential GPS (DGPS) service for coastal and other critical waterways of the United States. The DGPS service is intended to support a number of applications where system accuracy, reliability, and integrity are all critical to safe and efficient navigation. As part of the design effort, the Coast Guard has analyzed the accuracy, reliability, and integrity requirements of four DGPS applications: harbor and harbor approach navigation, vessel traffic service (VTS) surveillance, aids to navigation (ATON) positioning, and exclusive economic zone (EEZ) surveying. This paper provides an overview of the DGPS design efforts, and describes the analysis methodologies used to derive the DGPS reliability and integrity requirements.
Kidney Exchange (2004)

Most transplanted kidneys are from cadavers, but there are also many transplants from live donors. Recently, there have started to be kidney exchanges involving two donor-patient pairs such that each donor cannot give a kidney to the intended recipient because of immunological incompatibility, but each patient can receive a kidney from the other donor. Exchanges are also made in which a donor-patient pair makes a donation to someone waiting for a cadaver kidney, in return for the patient in the pair receiving high priority for a compatible cadaver kidney when one becomes available. There are stringent legal/ethical constraints on how exchanges can be conducted. We explore how larger scale exchanges of these kinds can be arranged efficiently and incentive compatibly, within existing constraints. The problem resembles some of the “housing” problems studied in the mechanism design literature for indivisible goods, with the novel feature that while live donor kidneys can be assigned simultaneously, cadaver kidneys cannot. In addition to studying the theoretical properties of the proposed kidney exchange, we present simulation results suggesting that the welfare gains from larger scale exchange would be substantial, both in increased number of feasible live donation transplants, and in improved match quality of transplanted kidneys.
Macrophage migration inhibitory factor promotes resistance to glucocorticoid treatment in EAE (2015)

Our data establish MIF as a key molecule in resistance of pathogenic CD4(+) T cells to GC treatment in EAE and as a potential target to enhance the effectiveness of steroid treatment in neuroinflammatory disorders.
Using TCAS surveillance to enable legacy ADS-B transponder use for in-trail procedures (2012)

In-Trail Procedures (ITP) is an application of Automatic Dependent Surveillance-Broadcast (ADS-B) that allows aircraft to change flight levels in areas where current non-radar separation standards would prevent desirable altitude changes. The ITP avionics receive ADS-B Out position reports from aircraft at intermediate flight levels that could be blocking the desired climb or descent maneuver. The most recent standard for ADS-B broadcast is RTCA/DO-260B [1]. This is also known as Version 2. Equipage is mandated by 2020 in the US for the same aircraft that carry transponders. Equipage is mandated in Europe by 2015 for forward fit aircraft and by 2017 for retrofit aircraft. Standards have been developed for the ADS-B data accuracy requirements for ITP [2, 3]. The standards are straightforward to apply to aircraft equipped with transponders certified to DO-260B [1]. The standards are less straightforward to apply for aircraft equipped with transponders certified to the earlier standards of ADS-B, which are known as Version 0 or Version 1 [4, 5]. This paper shows that crosschecking ADS-B data with Traffic Alert and Collision Avoidance System (TCAS) data is an effective mitigation technique for uncertain ADS-B horizontal position accuracy and integrity for legacy Version 0 and Version 1 ADS-B transponders.
De flora van Arnhem, toen en nu (1978)

Between 1923 en 1933 Prof. Van Soest published a series of 8 papers about the Flora of Arnhem. Between 1970 and 1978 this area has been investigated again and the author mentions a great number of interesting data with reference to both investigations.
Cellular inhibitors of long interspersed element 1 and Alu retrotransposition (2006)

Long interspersed element (LINE) 1 retrotransposons are major genomic parasites that represent approximately 17% of the human genome. The LINE-1 ORF2 protein is also responsible for the mobility of Alu elements, which constitute a further approximately 11% of genomic DNA. Representative members of each element class remain mobile, and deleterious retrotransposition events can induce spontaneous genetic diseases. Here, we demonstrate that APOBEC3A and APOBEC3B, two members of the APOBEC3 family of human innate antiretroviral resistance factors, can enter the nucleus, where LINE-1 and Alu reverse transcription occurs, and specifically inhibit both LINE-1 and Alu retrotransposition. These data suggest that the APOBEC3 protein family may have evolved, at least in part, to defend the integrity of the human genome against endogenous retrotransposons.
Repeating and Remembering Foreign Language Words: Does Seeing Help? (1998)

Normal hearing people use lip-reading when listening conditions are not good [1]. Yet even when the listening environment is ideal, lip reading can help with a difficult signal such a listening to a foreign language [2]. These authors demonstrated that non-native French student’s shadowing performance of French was improved by seeing the lips and mandible of the speaker. This observation suggests that learning the sounds of a foreign language may be aided by audio-visual presentation compared with audio alone. One recent example of such an application of the audio-visual approach has been in teaching a foreign alphabet by children [3]. The current experiment extended this approach by examining whether the mode of presentation affected the accuracy of repetitions of short phrases of a language participants had not heard before (Korean). Participants either heard a (five syllable) Korean phrase while watching the top part of face (no lips or jaw) or heard the phrase while watching the lips and jaw of the speaker. Three native speakers (blind to the presentation status of the participant) judged the accuracy of the participants' subsequent rendition of the phrase. The experiment also examined whether presentation mode affected performance on a subsequent old/new recognition task of the experimental phrases. The results are discussed in relation to the relative contribution of auditory and visual information in L2 acquisition in the immediate and longer term.
Very high resolution aerial data to support multi-temporal precision agriculture information management (2017)

The usage of small-sized unmanned aerial systems (UAS) has increased in the last years, in many different areas, being agriculture and forestry those who benefit the most from this relatively new remote sensing platform. Leaf area index, canopy and plant volume are among the parameters that can be determined using the very high resolution aerial data obtained by sensors coupled in unmanned aerial vehicles (UAV). This remote sensing technology affords the possibility of monitoring the vegetative development, identifying different types of issues, enabling the application of the most appropriated treatments in the affected areas. In this paper, a methodology allowing to perform multi-temporal UAS-based data analysis obtained by different sensors is proposed. A case study in vineyards and chestnuts is used to prove the benefits of continuous crop monitoring in its management and productivity of agroforestry parcels/activities.
Cleavage of 2-Phenyl-1,3-dioxolanes and Benzyl Ethers by Catalytic Transfer Hydrogenation (1986)

The selective deprotection of 2-phenyl-1,3-dioxolane derivatives and benzyl ethers of carbohydrates can be accomplished by catalytic transfer hydrogenation using hydrazine hydrate as hydrogen donor and 10% palladium on carbon as catalyst. Under these conditions, 2-phenyl-1,3-dioxan and 2-alkyl-substituted 1,3-dioxolane moieties remain unaffected. The proposed method is effective and the deprotected compounds are obtained in high yields.
Mesoporous Silica-Coated Hollow Manganese Oxide Nanoparticles as Positive <i>T</i><sub>1</sub> Contrast Agents for Labeling and MRI Tracking of Adipose-Derived Mesenchymal Stem Cells (2011)

Mesoporous silica-coated hollow manganese oxide (HIVInO@ mSiO(2)) nanoparticles were developed as a novel T-1 magnetic resonance imaging (MRI) contrast agent. We hypothesized that the mesoporous structure of the nanopartide shell enables optimal access of water molecules to the magnetic core, and consequently, an effective longitudinal (R-1) relaxation enhancement of water protons, which value was measured to be 0.99 (mM(-1) s(-1)) at 11.7 T. Adipose-derived mesenchymal stem cells (MSCs) were efficiently labeled using electroporation, with much shorter T-1 values as compared to direct incubation without electroporation, which was also evidenced by signal enhancement on T-1-weighted MR images in vitro. Intracranial grafting of HMnO@mSiO(2)-labeled MSCs enabled serial MR monitoring of cell transplants over 14 days. These novel nanopartides may extend the arsenal of currently available nanoparticie MR contrast agents by providing positive contrast on T-1-weighted images at high magnetic field strengths.
Posterior atlantoaxial stabilization: new alternative to C1–2 transarticular screws (2002)

Object Surgical treatment of atlantoaxial instability has evolved to include various posterior wiring techniques including Brooks, Gallie, and Sonntag fusions in which success rates range from 60 to 100%. The Magerl–Seemans technique in which C1–2 transarticular screws are placed results in fusion rates between 87 and 100%. This procedure is technically demanding and requires precise knowledge of the course of the vertebral arteries (VAs). The authors introduce a new C1–2 fixation procedure in which C-1 lateral mass and C-2 pedicle screws are placed that may have advantages over C1–2 transarticular screw constructs. Methods A standard posterior C1–2 exposure is obtained. Polyaxial C-2 pedicle screws and C-1 lateral mass screws are placed bilaterally. Rods are connected to the screws and secured using locking nuts. A cross-link is then placed. Fusion can be performed at the atlantoaxial joint by elevating the C-2 nerve root. The technique for this procedure has been used in four cases of atlantoaxial instability at the author's institution. There have been no C-2 nerve root– or VA-related injuries. No cases of construct failure have been observed in the short-term follow up period. Conclusions Atlantoaxial lateral mass and axial pedicle screw fixation offers an alternative means of achieving atlantoaxial fusion. The technique is less demanding than that required for transarticular screw placement and may avoid the potential complication of VA injury. The cross-linked construct is theoretically stable in flexion, extension, and rotation. Laminectomy or fracture of the posterior elements does not preclude use of this fixation procedure.
Image Matching Using SIFT, SURF, BRIEF and ORB: Performance Comparison for Distorted Images (2017)

Fast and robust image matching is a very important task with various applications in computer vision and robotics. In this paper, we compare the performance of three different image matching techniques, i.e., SIFT, SURF, and ORB, against different kinds of transformations and deformations such as scaling, rotation, noise, fish eye distortion, and shearing. For this purpose, we manually apply different types of transformations on original images and compute the matching evaluation parameters such as the number of key points in images, the matching rate, and the execution time required for each algorithm and we will show that which algorithm is the best more robust against each kind of distortion. Index Terms-Image matching, scale invariant feature transform (SIFT), speed up robust feature (SURF), robust independent elementary features (BRIEF), oriented FAST, rotated BRIEF (ORB).
Paralytic Disease Associated With Oral Polio Vaccines (1964)

SINCE 1961 when the oral poliomyelitis vaccines were first made available for general use in the United States, scattered cases of paralytic disease have occurred in association with these vaccines. Many of the cases have been clinically indistinguishable from poliomyelitis. Epidemiologically, the pattern of their occurrence has raised the possibility that some may have been caused by the vaccine. In 1962 when the existence of this problem was first appreciated, the Surgeon General of the Public Health Service convened a special advisory committee which met on a number of occasions between August and December. The Committee reviewed in detail reported cases of paralytic disease occurring within a period of 30 days following ingestion of the oral poliomyelitis vaccines. The Committee concluded that 18 cases of paralytic poliomyelitis were "compatible with the possibility of having been induced by the vaccine." Of these, 11 followed type III vaccine and 7 followed type
The History and State of the Art of Variable‐Speed Wind Turbine Technology (2003)

Abstract Early wind turbines used for performing mechanical work (pumping, grinding and cutting) optimized aerodynamics by being allowed to run at variable speed. Some of the earliest DC electric wind turbines were allowed to run at variable speed. With the advent of grid‐connected AC turbines, rotational speeds were limited in order to control the wind turbine AC frequency output to equal the grid frequency. With the advent of semiconductor devices, attempts began as early as the 1970s to allow variable‐speed operation of large‐scale turbines. The introduction of a new generation of high‐voltage, high‐speed power electronic components allows a wide range of variable‐speed operation for very‐large‐scale machines. Over the past 30 years a number of designs have been tested, a few of which have entered commercial operation. A number of these designs and their histories are described. A detailed description of a wide range of electrical methods for allowing variable‐speed operation is provided. Copyright © 2003 John Wiley & Sons, Ltd.
Development and validation of a bioreactor for physical stimulation of engineered cartilage (2003)

A bioreactor has been developed to apply different regimes of physical stimulation to tissue specimens under highly controlled conditions. The computer-controlled device exposes specimens to compressive deformation at various strains and frequencies, measures the load applied to each sample and allows simultaneous medium stirring at different velocities. Validation tests confirmed the accuracy of the system in (i) its displacement (errors averaged 0.072+/-0.051 microm), and in (ii) setting the contact with the samples utilizing micrometer screws coupled to plungers (errors averaged 1.74+/-0.36% for samples of 1.60-3.18 mm thickness), thus ensuring accurate compressive deformation. The developed bioreactor, which represents an advance in the technology for physical stimulation of tissue specimens, is currently used to apply compressive deformation and hydrodynamic forces to human chondrocytes cultured in biodegradable polymer scaffolds, with the goals of (i) engineering functional grafts for the repair of cartilage defects (ii).
Cardiovascular responses to verapamil and propranolol in hypertensive patients. (1985)

Since there is concern that the potentially useful antihypertensive combination of verapamil and propranolol might lead to adverse cardiovascular responses, we have investigated its effects, not only on blood pressure, but also on electrocardiographic and echocardiographic variables. Fourteen hypertensive patients participated in a double-blind, randomized, crossover comparison of verapamil 360 mg, propranolol 240 mg, verapamil 360 mg + propranolol 240 mg, and placebo, each given for 4 weeks. The antihypertensive effect of verapamil + propranolol was greater than that of either drug alone. Pulse rate was reduced by propranolol but not verapamil. However, addition of verapamil to propranolol led to further reduction in pulse rate. The PR interval was prolonged by verapamil + propranolol when compared with all other treatments. The active drugs increased ventricular dimensions and the effect of the combination was statistically significant. Thus, verapamil + propranolol is an effective antihypertensive combination, but heart rate, atrio-ventricular conduction and left ventricular function may be affected adversely, necessitating careful monitoring of therapy.