gebhart/patrepeval huggingface dataset:
[Immunological aspects of inflammatory bowel diseases (author's transl)]. (1978)

The gastrointestinal tract is replete with immunocompetent tissue represented by appendix, Peyer's patches and nonaggregated lymphocytes in the intestinal epithelium. This local immune system plays a vital role in the physiologic immune response and in the control of food, drug, microbial or viral antigens. Under certain situations this lymphoid tissue may contribute to the immunological reactions underlying the pathogenesis of various diseases. Generalised deficiencies of the immune apparatus frequently give rise to disturbances of gastrointestinal function. Furthermore plenty of immune reactions occurring in connection with human inflammatory bowel disease have been described. Some immunologic features are reported as typical for a disease, the majority seems to indicate only nonspecific autoimmune reactions. The relevance of immunological mechanisms for the pathogenesis of these diseases is still not full evaluated.
Receivers with chip-level decision feedback equalizer for CDMA downlink channels (2004)

For the code division multiple access (CDMA) downlink channel, we investigate the decision feedback equalizer (DFE) at chip-level to effectively suppress multiple-access interference (MAI) when the spreading sequences are orthogonal. The structure of the receiver with the chip-level DFE has been investigated and the minimum mean-square error solution has been derived. Due to the inherent structure of the chip-level DFE, some iterative techniques with hard and soft decisions have been proposed. It is shown that the proposed receivers with the chip-level DFE can provide satisfactory performance. In comparison with the adaptive chip-level linear equalizer, the number of users can be doubled by using adaptive chip-level DFE at a bit-error rate of 10/sup -3/. Throughout the paper, we assume that scrambled orthogonal codes are used for spreading sequences.
A stereo vision-based augmented reality system with an inertial sensor (2002)

This paper proposes a robust registration method with stereo cameras and an inertial sensor for augmented reality. The geometric registration is one of the most important problems because virtual objects should be superimposed on the right place as if they really exist in the real world. The vision-based registration is achieved by estimating a position and an orientation of camera(s) by tracking markers in the real world. The proposed method realizes a robust tracking of markers using stereo images and a camera orientation obtained by the inertial sensor.
Plasticity of Regulatory T Cells: Subversion of Suppressive Function and Conversion to Enhancement of Lung Allergic Responses (2008)

Activation of CD4(+)CD25(+)Foxp3(+) naturally occurring regulatory T cells (nTregs) resulting in suppression of lung allergic responses requires interaction of MHC class I on nTregs and CD8. In the absence of CD8 (CD8(-/-) recipients), transferred nTregs restored airway hyperresponsiveness, eosinophilic inflammation, and IL-13 levels following allergen exposure. Enhancement of lung allergic responses was accompanied by reduced expression of Foxp3 and increased expression of IL-13 in the transferred nTregs. In CD8(-/-) recipients pretreated with glucocorticoid-induced TNFR-related protein-ligand Ab, the transferred nTregs maintained high levels of Foxp3 and did not result in altered lung responses. Thus, the regulatory function of nTregs can be subverted by reducing the expression of Foxp3 and following signaling through glucocorticoid-induced TNFR-related protein are converted nTregs into IL-13-producing CD4(+) T cells mediating lung allergic responses.
Divalent Cations Stabilize the α1β1 Integrin I Domain (1999)

Recent structural and functional analyses of alpha integrin subunit I domains implicate a region in cation and ligand binding referred to as the metal ion-dependent adhesion site (MIDAS). Although the molecular interactions between Mn2+ and Mg2+ and the MIDAS region have been defined by crystallographic analyses, the role of cation in I domain function is not well understood. Recombinant alpha 1 beta 1 integrin I domain (alpha1-I domain) binds collagen in a cation-dependent manner. We have generated and characterized a panel of antibodies directed against the alpha1-I domain, and selected one (AJH10) that blocks alpha 1 beta 1 integrin function for further study. The epitope of AJH10 was localized within the loop between the alpha 3 and alpha 4 helices which contributes one of the metal coordination sites of the MIDAS structure. Kinetic analyses of antibody binding to the I domain demonstrate that divalent cation is required to stabilize the epitope. Denaturation experiments demonstrate that cation has a dramatic effect on the stabilization of the I domain structure. Mn2+ shifts the point at which the I domain denatures from 3.4 to 6.3 M urea in the presence of the denaturant, and from 49.5 to 58.6 degrees C following thermal denaturation. The structural stability provided to the alpha1-I domain by divalent cations may contribute to augmented ligand binding that occurs in the presence of these cations.
MOTION MEASUREMENT BY LASER DOPPLER TECHNIQUES (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMOTION MEASUREMENT BY LASER DOPPLER TECHNIQUESJohn C. Angus, David L. Morrow, John W. Dunning, and Michael J. FrenchCite this: Ind. Eng. Chem. 1969, 61, 2, 8–20Publication Date (Print):February 1, 1969Publication History Published online1 May 2002Published inissue 1 February 1969https://pubs.acs.org/doi/10.1021/ie50710a005https://doi.org/10.1021/ie50710a005research-articleACS PublicationsRequest reuse permissionsArticle Views86Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Automated support for seamless interoperability in polylingual software systems (1996)

Interoperability is a fundamental concern in many areas of software engineering, such as software reuse or infrastructures for software development environments. Of particular interest to software engineers are the interoperability problems arising in polylingual software systems. The defining characteristic of polylingual systems is their focus on uniform interaction among a set of components written in two or more different languages.Existing approaches to support for interoperability are inadequate because they lack seamlessness: that is, they generally force software developers to compensate explicitly for the existence of multiple languages or the crossing of language boundaries. In this paper we first discuss some foundations for polylingual interoperability, then review and assess existing approaches. We then outline PolySPIN, an approach in which interoperability can be made transparent and existing systems can be made to interoperate with no visible modifications. We also describe PolySPINner, our prototype implementation of a toolset providing automated support for PolySPIN. We illustrate the advantages of our approach by applying it to an example problem and comparing PolySPIN's ease of use with that of an alternative, CORBA-style approach.
Stable isotope dilution method for measurement of palmitate content and labeled palmitate tracer enrichment in microliter plasma samples. (1982)

In studies where [1-13C]palmitic acid is employed as isotopic tracer in vivo, we have described a selected ion monitoring gas-liquid chromatography-mass spectrometry micro-method which allows plasma tracer enrichment as well as plasma palmitate content to be determined in the same 100-microliter sample through the use of [5,5,6,6-2H4]palmitic acid as assay internal standard. For standard solutions in the range equivalent to plasma palmitic acid concentrations of 10--2500 microM, assay precision was +/- 5%. For plasma samples in the physiologic range (approximately 30--200 microM palmitate) assay precision averaged better than +/- 2%. The use of the method is illustrated by measuring palmitate turnover in a 12-hr-old human infant.
Structure of macrophage colony stimulating factor bound to FMS: Diverse signaling assemblies of class III receptor tyrosine kinases (2008)

Macrophage colony stimulating factor (M-CSF), through binding to its receptor FMS, a class III receptor tyrosine kinase (RTK), regulates the development and function of mononuclear phagocytes, and plays important roles in innate immunity, cancer and inflammation. We report a 2.4 A crystal structure of M-CSF bound to the first 3 domains (D1-D3) of FMS. The ligand binding mode of FMS is surprisingly different from KIT, another class III RTK, in which the major ligand-binding domain of FMS, D2, uses the CD and EF loops, but not the beta-sheet on the opposite side of the Ig domain as in KIT, to bind ligand. Calorimetric data indicate that M-CSF cannot dimerize FMS without receptor-receptor interactions mediated by FMS domains D4 and D5. Consistently, the structure contains only 1 FMS-D1-D3 molecule bound to a M-CSF dimer, due to a weak, hydrophilic M-CSF:FMS interface, and probably a conformational change of the M-CSF dimer in which binding to the second site is rendered unfavorable by FMS binding at the first site. The partial, intermediate complex suggests that FMS may be activated in two steps, with the initial engagement step distinct from the subsequent dimerization/activation step. Hence, the formation of signaling class III RTK complexes can be diverse, engaging various modes of ligand recognition and various mechanistic steps for dimerizing and activating receptors.
Dielectrically isolated saturating circuits (1968)

A description of the three main substrate preparation processes to achieve silicon dioxide dielectric isolation are described. The use of dielectric isolation for high-speed and low-power circuits is outlined, with calculations of saturation resistance and transient characteristics. Introduction of carrier lifetime-reducing gold into a dielectrically isolated wafer can cause problems, which are delineated. Final results are listed and Photomicrographs of working circuits are presented.
Highly-efficient, low-noise Si hybrid laser using flip-chip bonded SOA (2012)

We developed a Si hybrid laser integrating Si wavelength filter and flip-chip bonded SOA. A high-output-power of 14.4 mW and wall-plug efficiency of 6.2% were obtained together with a low RIN level of <;-135 dB/Hz.
Waves Michelson Interferometer: a visible/near-IR interferometer for observing middle atmosphere dynamics and constituents (2001)

The Waves Michelson Interferometer (WAMI) is designed to provide simultaneous measurements of dynamical and constituent signatures in the upper stratosphere, mesosphere and lower thermosphere. It is being included as part of the Waves Explorer mission (G. Swenson, P.I. being proposed for NASA's MIDEX program. It is a field-widened Michelson interferometer based on the same design principle as the successful Wind Imaging Interferometer (WINDII). WAMI includes visible and near-IR channels, a segmented interferometer mirror for simultaneous fringe sampling at different optical paths and views the atmosphere in six distinct directions. Use of the segmented mirrors minimizes the aliasing of atmospheric intensity variations into the fringe parameter determinations. This technique also allows two emissions to be viewed simultaneously through the same optical channel. The emissions chosen include lines in the molecular oxygen IR-atmospheric band, a doublet in the hydroxyl Meinel bands and the oxygen green line. The daytime coverage includes winds from 45 to 180 km, and rotational temperature and ozone density from 45 to 95 km. The nighttime coverage is restricted to the airglow layer centered near 90 km where atomic oxygen, horizontal wind and rotational temperature measurements are provided. These measurements provide a rich data set from which dynamics, energetics and constituent budgets can be determined.
Optical levitation and translation of a microscopic particle by use of multiple beams generated by vertical-cavity surface-emitting laser array sources (2002)

An optical levitation and translation method for a microscopic particle by use of the resultant force induced by multiple light beams is studied. We show dependence of the radiation pressure force on the illuminating distribution by numerical calculation, and we find that the strongest axial force is obtained by a specific spacing period of illuminating beams. Extending the optical manipulation technique by means of vertical-cavity surface-emitting laser (VCSEL) array sources [Appl. Opt. 40, 5430 (2001)], we are the first, to our knowledge, to demonstrate levitation of a particle and its translation while levitated by using a VCSEL array. The vertical position of the target particle can be controlled in a range of a few tens of micrometers with an accuracy of 2 microm or less. The analytical and experimental results suggest that use of multiple beams is an effective method to levitate a particle with low total illumination power. Some issues on the manipulation method that uses multiple beams are discussed.
Upper Extremity Snowboarding Injuries (2000)

A survey of snowboarding injuries was conducted over 10 seasons (1988 to 1998). A questionnaire evaluating 20 variables was used to collect data from 47 medical facilities near Colorado ski resorts. A total of 7430 snowboarding-related injuries were seen. A control group consisted of 3107 noninjured snowboarders. Most of those injured were 30 years of age or younger; 74% of injuries occurred in men and 26% in women; 39% of injured snowboarders were beginners and 61% were intermediate or experts. Men rode at more advanced levels than women. Injured snowboarders were more likely than noninjured snowboarders to be beginners. There were 3645 (49.06% of total) upper extremity injuries; 56.43% were fractures, 26.78% sprains, and 9.66% dislocations. The most common site of injury was the wrist (21.6% of all snowboarding injuries). Wrist fractures (except to the scaphoid) and sprains were more common in beginners, women, and younger age groups. Intermediate and expert men were more likely to sustain hand, elbow, and shoulder injuries, as well as more severe injuries. Falling was the predominant mechanism of upper extremity injuries. Snowboarders who wore protective wrist guards were half as likely to sustain wrist injuries as those who did not wear guards.
Glucose-6-Phosphate Dehydrogenase Deficiency in Sickle-Cell Anemia (1974)

There is evidence that the prevalence of G-6-PD deficiency is greater than would be expected in individuals with sickle-cell anemia, which suggests a survival advantage for these patients. We have studied 45 individuals with sickle-cell anemia, with methods for detecting G-6-PD deficiency in the presence of reticulocytosis, and we have found its prevalence to be similar to that of control subjects. The patients were mostly adults with mild sickle-cell disease. The differences between our findings and those reported previously may be partly owing to the nature of the populations studied. Our findings do not provide evidence that G-6-PD deficiency in adults with sickle-cell anemia gives them any advantage in survival.
Diversity and versatility of GTPase activating proteins for the p21rho subfamily of ras G proteins detected by a novel overlay assay. (1992)

The p21ras superfamily, involved in diverse processes including cell growth and intracellular trafficking, possesses intrinsic GTPase activity and cycles between GTP-bound active and GDP-bound quiescent states. This intrinsic activity, which results in down-regulation, is accelerated by GTPase activating proteins (GAPs). Other proteins regulating the GDP/GTP cycle include exchange proteins and dissociation inhibitors. The p21s rho, rac, and cdc42Hs constitute a subfamily implicated in cytoskeletal organization. BCR and n-chimaerin are prototypes of a new GAP family for these p21s. To investigate proteins modulating GTP hydrolysis of the three p21s, we developed a novel overlay assay applicable to tissue extracts. Diverse GAPs with different specificities were identified in all rat tissues. Brain contained rac1 GAPs of 45, 50, 85, 100, and 150 kDa. The p50 and p150 GAPs also act on rhoA and cdc42Hs and are ubiquitous, while the p45-GAP, n-chimaerin, is brain- and testis-specific and acts preferentially on rac1; the p100 GAP acts on both rac1 and cdc42Hs and is brain-specific. A new class of p21-interacting proteins was also identified. This diversity, versatility, and tissue specificity of GAPs may be required for fine control of the down-regulation of GTP-bound p21s and the suggested specific downstream effects of individual GAPs, which could involve "cross-talk" between GAPs and p21s.
Food allergy: Riding the second wave of the allergy epidemic (2011)

Food allergy is a substantial and evolving public health issue, recently emerging over the last 10-15 yr as a 'second wave' of the allergy epidemic. It remains unclear why this new phenomenon has lagged decades behind the 'first wave' of asthma, allergic rhinitis and inhalant sensitization. In regions like Australia, which lead the respiratory epidemic, challenge-proven IgE-mediated food allergy now affects up to 10% of infants. Although their parents were among the first generation to experience the large-scale rise in allergic diseases, disorders of oral tolerance were previously uncommon. Of further concern, this new generation appears less likely to outgrow food allergy than their predecessors with long-term implications for disease burden. Allergic disease has been linked to the modern lifestyle including changing dietary patterns, changing intestinal commensal bacteria and vehicular pollution. It is not yet known whether the rise in food allergy is a harbinger of earlier and more severe effects of these progressive environmental changes or whether additional or unrelated lifestyle factors are implicated. New studies suggest environmental factors can produce epigenetic changes in gene expression and disease risk that may be potentially heritable across generations. The rising rates of maternal allergy, a strong direct determinant of allergic risk, could also be amplifying the effect of environmental changes. Preliminary evidence that non-Caucasian populations may be even more susceptible to the adverse effects of 'westernisation' has substantial global implications with progressive urbanization of the more populous regions in the developing world. Unravelling the environmental drivers is critical to curtail a potential tsunami of allergic disease.
Ultra-Low Power Nanomagnet-Based Computing: A System-Level Perspective (2010)

MOSFET scaling is facing overwhelming challenges with increased parameter variations, exponentially higher leakage current, and higher power density. Thus, researchers have started looking at alternative switching devices and spintronics-based computing paradigms. Nanomagnet-based computing is one such paradigm with intrinsic switching energy close to thermal limits and scalability down to 5 nm. In this paper, we explore the possibility of nanomagnet-based design using nonmajority gates. The design approach can offer significant area, delay, and energy advantages compared to majority-gate-based designs. Moreover, new clock technologies and architectures are developed to improve computation robustness and power dissipation of nanomagnet systems. We also developed a comprehensive device/circuit/system compatible simulation framework to evaluate the functionality and architecture of a nanomagnet system and conducted a feasibility/comparison study to determine the effectiveness of the technology compared to standard digital electronics. Performance results from a nanomagnet-based 16-point discrete cosine transform (DCT) with enhanced clock architecture, narrow gap cladding of nanomagnets, or embedding nanomagnets in solenoid with steel core, together with near neighbor system architecture, show up to 10 × improvement over subthreshold 15 nm CMOS (Vdd = 90 mV) design, using “energy-delay <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.5</sup> -area product (ED <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.5</sup> A)” as comparison metric. Finally, we explored the scalability of nanomagnets and the effectiveness of field-based switching.
Peaked distribution ethoxylates‐Their preparation, characterization and performance evaluation (1986)

Abstract A peaked ethylene oxide distribution alcohol ethoxylate can be produced using new catalyst systems. The mechanism of ethoxylation is discussed. Such Novel™ ethoxylates are markedly different from a conventional ethoxylate in physical properties and performance characteristics. Performance and formulation studies show several advantages for the peaked distribution in typical household product formulations.
In vitro properties of human melanoma cells metastatic in nude mice. (1990)

We have developed a human melanoma metastasis model in nude mice. In this model, a human variant cell line (451-LU) was obtained that spontaneously metastasized in nude mice. This variant cell line was selected from the lung of a nude mouse after several in vivo passages of human melanoma WM164 cells previously isolated from a melanoma metastasis of a patient. The WM164 cells were not competent for metastasis in nude mice prior to this selection. We compared the phenotypes of the parental nonmetastatic cell line and the metastatic variant with respect to growth at clonal seeding densities in protein-free medium (growth factor independence), in vitro invasion through reconstructed basement membranes, secretion of proteolytic enzymes, expression of tumor-associated antigens, and chromosomal abnormalities. Metastatic 451-LU cells showed significantly increased growth factor independence when grown at clonal seeding densities as compared to the parental cells. In in vitro chemoinvasion assays, metastatic 451-LU cells were significantly more invasive than the parental cells. The metastatic variant secreted collagenase and tissue type plasminogen activator at levels 10- and 3-fold higher than the parental WM164 cells, respectively. Polyclonal antibodies to tissue type plasminogen activator significantly inhibited invasion through reconstructed basement membranes. In metastatic 451-LU cells, expression of nerve growth factor receptor was elevated, both at the protein and transcriptional level. Metastatic cells were aneuploid with a mode of 97 chromosomes, whereas the parental nonmetastatic cells had a mode of 52 chromosomes. Our studies suggest that metastatic melanoma cell variants selected in vivo show increased independence of exogenous growth factors when grown at clonal cell densities, enhanced invasiveness in vitro, greater secretion of proteolytic enzymes, and increased chromosome mode as compared to the nonmetastatic parental cells. The data further suggest that melanoma cells isolated from metastatic lesions and maintained in vitro have an unstable invasive phenotype but that metastatic variant cells can readily be selected.