gebhart/patrepeval huggingface dataset:
Role of the modified (glycosaminoglycan producing) perisinusoidal fibroblasts in the CCl4-induced fibrosis of the rat liver. (1992)

Development and regression of liver fibrosis and cirrhosis induced by CCl4 in male F-344 rats were strictly followed during and after an 8-week treatment. The relative amount of collagen was measured by morphometry and the number of glycosaminoglycan (GAG) containing fat storing cells was counted at each time point. The expression of proteoglycan genes (decorin, versican and BPG-5 HSPG) was studied in parallel with the development of cirrhosis. Collagen content of the liver as well as the number of GAG-containing mesenchymal (fat storing) cells increased in parallel until two weeks after the cessation of CCl4 treatment. Later, both the collagen content and the number of GAG-containing cells decreased in parallel and significantly. Proteoglycan gene expression in the nonparenchymal fraction of liver cells indicated an active proteoglycan synthesis in the course of the development of cirrhosis. It is concluded that modified Ito (fat storing) cells synthesize proteoglycans and play an important role in the formation of connective tissue fibers in liver fibrosis.
Smart Energy management of Li-ion battery / Supercapacitor Hybrid Energy Storage System for Electric Vehicle Application (2019)

International audience
Theoretical study on dependence of thermal switching time of synthetic free layer on coupling field (2012)

The thermally assisted spin torque switching of a synthetic free layer was studied theoretically. Based on the rate equation, theoretical formulas of the switching probability, the switching current, and the standard deviation of the current were obtained. We showed that the switching time is proportional to the coupling field. We also showed that the standard deviation of the current is independent of the coupling field.
Graphene-Encapsulated Hollow Fe<sub>3</sub>O<sub>4</sub> Nanoparticle Aggregates As a High-Performance Anode Material for Lithium Ion Batteries (2011)

Graphene-encapsulated ordered aggregates of Fe(3)O(4) nanoparticles with nearly spherical geometry and hollow interior were synthesized by a simple self-assembly process. The open interior structure adapts well to the volume change in repetitive Li(+) insertion and extraction reactions; and the encapsulating graphene connects the Fe(3)O(4) nanoparticles electrically. The structure and morphology of the graphene-Fe(3)O(4) composite were confirmed by X-ray diffraction, scanning electron microscopy, and high-resolution transmission microscopy. The electrochemical performance of the composite for reversible Li(+) storage was evaluated by cyclic voltammetry and constant current charging and discharging. The results showed a high and nearly unvarying specific capacity for 50 cycles. Furthermore, even after 90 cycles of charge and discharge at different current densities, about 92% of the initial capacity at 100 mA g(-1) was still recoverable, indicating excellent cycle stability. The graphene-Fe(3)O(4) composite is therefore a capable Li(+) host with high capacity that can be cycled at high rates with good cycle life. The unique combination of graphene encapsulation and a hollow porous structure definitely contributed to this versatile electrochemical performance.
Role of local prostaglandin synthesis in the modulation of proliferative activity of rat colonic epithelium. (1983)

The role of local prostaglandin (PG) synthesis in the modulation of the proliferative activity of colonic epithelium was examined in rat colon. Experimental rats were given either indomethacin (5 mg/kg s.c. every 8 h for three doses) or aspirin (0.5 g/100 g diet for 3 d). In rats treated with indomethacin or aspirin, the incorporation of [3H]thymidine (dThd) into DNA in vivo was increased approximately twofold over control in mucosal scrapings from distal colon, and approximately threefold over control in the proliferating pool of epithelial cells isolated from distal colon. [3H]dThd incorporation into DNA was also examined ex vivo immediately after distal colonic resection. It was approximately twofold higher in mucosa of colonic segments (1-h incubation) from rats treated with indomethacin or aspirin in vivo, compared with corresponding values of segments from control rats. Immunoreactive (i) prostaglandin E (PGE), the dominant PG product of colon segment incubates by high-performance liquid chromatography analysis of [14C]arachidonate metabolites, was markedly (95%) reduced in the media of 1-h colon incubates from indomethacin- or aspirin-treated rats, compared with control rats. Moreover, the cyclic (c)AMP content of mucosa of segments from indomethacin- or aspirin-treated rats was significantly lower than that of control rats. Prolonged incubation (4-24 h) of colonic segments from indomethacin-treated rats, in the absence of indomethacin in vitro, led to an eventual return of [3H]dThd incorporation into DNA, iPGE, and mucosal cAMP to control values. Conversely, inclusion of indomethacin (0.25 mM) in the incubations (6 h) of colonic segments from indomethacin-treated rats resulted in persistent suppression of iPGE and mucosal cAMP, as well as persistent enhancement of [3H]dThd incorporation into mucosal DNA. However, incubation of colonic segments from control rats (no in vivo drug exposure) with indomethacin or aspirin in vitro for periods up to 24 h failed to alter DNA synthesis, despite marked reduction in media iPGE and lower mucosal cAMP. The latter observations suggested that additional in vivo factors initiated the enhancement of DNA synthesis in indomethacin- or aspirin-treated rats. Exogenous PGE2, D2, I2, or F2 alpha, each of which increased the endogenous mucosal cAMP content of incubated colonic segments from control, indomethacin- or aspirin-treated rats, all suppressed [3H]dThd incorporation into mucosal DNA in vitro. Dibutyryl cAMP, but not dibutyryl cGMP, had an analogous suppressive effect on in vitro [3H]dThd incorporation into DNA. Thus, the present observations are consistent with an inhibitory action of endogenous colonic PG synthesis on the proliferative activity of colonic epithelium. This action may be mediated through cAMP.
Design of Digital Polarity Correlators in a Multiple-User Sonar Ranging System (2005)

Pulsed ultrasonic distance measurement systems are frequently used in robotics applications thanks to their low cost and small size. The pulse compression techniques, originally developed by radar engineers, were adopted to eliminate frequent misreadings caused by crosstalk or external ultrasound sources. However, a few problems become apparent when implementing the pulse compression techniques in robotics applications. First, due to the implementation of correlation functions, the complexity of the total system may significantly increase. Second, if the piezoelectric transducer is excited by a chirp signal, efficiency is reduced due to the narrow bandwidth. In this paper, we present a digital polarity correlator designed for binary coded frequency shift keyed signals which increase the number of different sequences having the same length in a restricted band. The digital signal processing system is integrated into a single programmable logic device. Experimental measurements have been made, and a good agreement with reference data has been obtained with noise added.
Clustering based approach to learning regular expressions over large alphabet for noisy unstructured text (2010)

Regular Expressions have been used for Information Extraction tasks in a variety of domains. The alphabet of the regular expression can either be the relevant tokens corresponding to the entity of interest or individual characters in which case the alphabet size becomes very large. The presence of noise in unstructured text documents along with increased alphabet size of the regular expressions poses a significant challenge for entity extraction tasks, and also for algorithmically learning complex regular expressions. In this paper, we present a novel algorithm for regular expression learning which clusters similar matches to obtain the corresponding regular expressions, identifies and eliminates noisy clusters, and finally uses weighted disjunction of the most promising candidate regular expressions to obtain the final expression. The experimental results demonstrate high value of both precision and recall of this final expression, which reinforces the applicability of our approach in entity extraction tasks of practical importance.
Three-photon excited fluorescence imaging of unstained tissue using a GRIN lens endoscope (2013)

We present a compact and portable three-photon gradient index (GRIN) lens endoscope system suitable for imaging of unstained tissues, potentially deep within the body, using a GRIN lens system of 1 mm diameter and 8 cm length. The lateral and axial resolution in water is 1.0 μm and 9.5 μm, respectively. The ~200 μm diameter field of view is imaged at 2 frames/s using a fiber-based excitation source at 1040 nm. Ex vivo imaging is demonstrated with unstained mouse lung at 5.9 mW average power. These results demonstrate the feasibility of three-photon GRIN lens endoscopy for optical biopsy.
Comparing the safety, efficacy and recovery of intranasal midazolam vs. oral chloral hydrate and promethazine. (2002)

Intranasal midazolam administered using an atomizer is as safe (as assessed by physiologic parameters) and effective (as assessed by behavior ratings) as oral chloral hydrate/promethazine for conscious sedation of pediatric dental patients.
Bulk operations for space-partitioning trees (2004)

The emergence of extensible index structures, e.g., GiST (generalized search tree) [J.M. Hellerstein et al. (1995)] and SP-GiST (space-partitioning generalized search tree) [W. G Aref et al., (2001)], calls for a set of extensible algorithms to support different operations (e.g., insertion, deletion, and search). Extensible bulk operations (e.g., bulk loading and bulk insertion) are of the same importance and need to be supported in these index engines. In this paper, we propose two extensible buffer-based algorithms for bulk operations in the class of space-partitioning trees; a class of hierarchical data structures that recursively decompose the space into disjoint partitions. The main idea of these algorithms is to build an in-memory tree of the target space-partitioning index. Then, data items are recursively partitioned into disk-based buffers using the in-memory tree. Although the second algorithm is designed for bulk insertion, it can be used in bulk loading as well. The proposed extensible algorithms are implemented inside SP-GiST; a framework for supporting the class of space-partitioning trees. Both algorithms have I/O bound O(NH/B), where N is the number of data items to be bulk loaded/inserted, B is the number of tree nodes that can fit in one disk page, H is the tree height in terms of pages after applying a clustering algorithm. Experimental results are provided to show the scalability and applicability of the proposed algorithms for the class of space-partitioning trees. A comparison of the two proposed algorithms shows that the first algorithm performs better in case of bulk loading. However the second algorithm is more general and can be used for efficient bulk insertion.
Influence of Zaprinast on vascular tone and vasodilator responses in the cat pulmonary vascular bed (1993)

The influence of Zaprinast (M&B 22948), a guanosine 3',5'-cyclic monophosphate (cGMP)-specific phosphodiesterase inhibitor, was investigated in the pulmonary vascular bed of the cat under conditions of controlled blood flow and constant left atrial pressure. Under baseline conditions, injections of Zaprinast into the perfused lobar artery produced small decreases in lobar arterial pressure without altering systemic arterial or left atrial pressure. When tone was increased with U-46619, Zaprinast caused larger dose-dependent decreases in lobar arterial pressure without altering left atrial pressure. The decreases in lobar arterial pressure were reduced significantly by treatment with the nitric oxide (NO) synthesis inhibitor NG-nitro-L-arginine methyl ester (L-NAME) or the guanylate cyclase inhibitor methylene blue. Under elevated tone conditions, efferent vagal stimulation and intralobar injections of acetylcholine, substance P, NO solution, and the S-nitrosothiols [S-nitroso-N-acetylpenicillamine (SNAP) and S-nitroso-L-cysteine (CysNO)] decreased lobar arterial pressure in a frequency-dependent and dose-related manner. After treatment with Zaprinast, the decreases in lobar arterial pressure in response to efferent vagal stimulation, the endothelium-dependent vasodilators, and the nitrovasodilators were not changed, whereas the duration of the vasodilator responses as measured by the half times was increased significantly. Vasodilator responses to adenosine, albuterol, and pinacidil were not altered by Zaprinast. These data suggest that cGMP hydrolysis in the lung is rapid and that endothelium-derived NO is important in stimulating basal cGMP production and in regulating vascular tone.(ABSTRACT TRUNCATED AT 250 WORDS)
Temperature-insensitive offset reduction in a Hall effect device (1994)

A double current technique applied to a double boundary device produces dual boundary specific Hall effects even above room temperature. It is shown that current compensation allows in situ cancellation of the offset voltage in the Hall effect, originating from effective contact misalignments. Thus, this method reduces the temperature-dependent offset originating from the T dependence of the resistance, and improves the sensitivity of the Hall element to the external magnetic field. Possible applications such as field sensing elements, contactless switches, and position sensors are cited.
Dynein Light Chain LC8 Negatively Regulates NF-κB through the Redox-dependent Interaction with IκBα (2008)

Redox regulation of nuclear factor κB (NF-κB) has been described, but the molecular mechanism underlying such regulation has remained unclear. We recently showed that a novel disulfide reductase, TRP14, inhibits tumor necrosis factor α (TNFα)-induced NF-κB activation, and we identified the dynein light chain LC8, which interacts with the NF-κB inhibitor IκBα, as a potential substrate of TRP14. We now show the molecular mechanism by which NF-κB activation is redox-dependently regulated through LC8. LC8 inhibited TNFα-induced NF-κB activation in HeLa cells by interacting with IκBα and thereby preventing its phosphorylation by IκB kinase (IKK), without affecting the activity of IKK itself. TNFα induced the production of reactive oxygen species, which oxidized LC8 to a homodimer linked by the reversible formation of a disulfide bond between the Cys2 residues of each subunit and thereby resulted in its dissociation from IκBα. Butylated hydroxyanisol, an antioxidant, and diphenyleneiodonium, an inhibitor of NADPH oxidase, attenuated the phosphorylation and degradation of IκBα by TNFα stimulation. In addition LC8 inhibited NF-κB activation by other stimuli including interleukin-1β and lipopolysaccharide, both of which generated reactive oxygen species. Furthermore, TRP14 catalyzed reduction of oxidized LC8. Together, our results indicate that LC8 binds IκBα in a redox-dependent manner and thereby prevents its phosphorylation by IKK. TRP14 contributes to this inhibitory activity by maintaining LC8 in a reduced state.
No germline <i>TP53</i> mutations detected in familial and bilateral testicular cancer (1993)

Mutations in the TP53 gene are considered to be among the most common genetic alterations in human cancers. Both somatic and germline mutations have been found. Using polymerase chain reaction (PCR), constant denaturant gel electrophoresis (CDGE), and denaturing gradient gel electrophoresis (DGGE), we have examined 32 patients with bilateral and familial germ cell tumors (GCT) and two patients with sporadic GCT for germline mutations within the conserved regions of the gene. In addition, 15 tumors were screened for somatic mutations and analyzed for loss of heterozygosity (LOH) at the TP53 locus. Twelve tumors were analyzed for expression of TP53 via immunohistochemistry. Neither germline nor somatic TP53 mutations were detected. LOH was observed in one of five informative cases. No tumors showed increased expression of TP53 protein. These results indicate that alterations in the TP53 gene are not important for the predisposition to and development of GCT.
BULB MORPHOLOGY IN SOME WESTERN NORTH AMERICAN SPECIES OF ALLIUM (1973)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
Selective Oxidative Homo- and Cross-Coupling of Phenols with Aerobic Catalysts (2014)

Simple catalysts that use atom-economical oxygen as the terminal oxidant to accomplish selective ortho-ortho, ortho-para, or para-para homo-couplings of phenols are described. In addition, chromium salen catalysts have been discovered as uniquely effective in the cross-coupling of different phenols with high chemo- and regioselectivity.
Ultra‐Low Friction on 100Cr6‐Steel Surfaces After Direct Laser Interference Patterning (2014)

This study discusses the effects of surface topographies on the frictional behavior of 100Cr6 bearing steel. A solid state laser with nanosecond pulses is used to produce one‐ and two‐dimensional periodic micropatterns using direct laser interference patterning. Line‐, cross‐, and dot‐like patterns with pitches of 5 μm, and aspect ratios (AR) between 0.02 and 0.17 are fabricated. The friction tests of the surface textured samples are performed under lubricating conditions using a ball‐on‐disk configuration in rotating mode. The results show that through the surface structure a reduction of the friction coefficient from 25 to 65% can be achieved compared to unstructured surfaces. The smallest coefficients of friction are obtained for ARs between 0.07 and 0.11.
An Examination of Some Metaphorical Contexts for Biologically Motivated Computing (1994)

Biologically motivated computing seeks to transfer ideas from the biosciences to computer science. In seeking to make transfers it is helpful to be able to appreciate the metaphors which people use. This is because metaphors provide the context through which analogies and similes are made and by which many scientific models are constructed. As such, it is important for any rapidly evolving domain of knowledge to have developments accounted for in these terms. This paper seeks to provide one overview of the process of modelling and shows how it can be used to account for a variety of biologically motivated computational models. Certain key ideas are identified in the subsequent analysis of biological sources, notably, systemic metaphors. Three important aspects of biological thinking are then considered in the light of computer science applications: biological organization, the cell, and models of evolution. The analysis throughout the paper is descriptive rather than formalized so that a large variety of potential applications may be considered.
Application of CO-Foam as a Means of Reducing Carbon Dioxide Mobility (2006)

Abstract Reducing the mobility of carbon dioxide through co-injection of CO2 and a suitable surfactant solution to form a CO2-foam system is a promising method for improving the oil recovery in carbon dioxide flooding projects. This paper presents the results of a set of experiments on screening and selecting a suitable surfactant for CO2 -foam purposes in a carbonate porous medium, as well as the effect of various parameters on the mobility of the CO2-foam system. Four surfactants were examined and the one that performed best throughout the screening experiments was used in the subsequent flow experiments. The surfactants tested were Surfonic N- 95, Surfonic L24–9, Bio-Terge AS-40, and Chaser CD-1045. The screening criterion selected was the fall in foam height with time at 60 ° C for 0.1 wt% solution of the above mentioned surfactants. Chaser CD-1045 performed best in all screening tests and was used during the flow experiments. Flow experiments were conducted through a porous medium made of crushed carbonate at pressures of 8,270 kPa and 10,336 kPa, and temperatures of 22 ° C and 50 ° C. Mobility of CO2 -brine (simulating the WAG process) and CO2-surfactant systems were compared through a series of experiments. The effect of operating pressure and temperature, brine concentration, and the ratio of the amount of CO2 to total foam (i.e., foam quality) on the mobility of a CO2-foam system were investigated and results are presented. The results indicate that additional oil is recoverable for CO2-foam vs. the co-injection of CO2 and brine simulating the WAG process. Introduction From the pore-scale point of view, dense carbon dioxide is an ideal displacement fluid for many crude oils because it can achieve miscibility with oil through a multi-contact miscibility process under the pressure and temperature conditions of a wide range of reservoirs. However, even when pressure conditions for miscibility are met, this high microscopic sweep efficiency is not often approached in reservoir operations due to the non-uniformity of the flow patterns. Large-scale reservoir heterogeneities, such as fractures or high-permeability streaks, cause early breakthrough of injected carbon dioxide, which will reduce oil recovery efficiency. One effective way of increasing the ultimate oil recovery under CO2 flooding conditions is by reducing the mobility of the injected carbon dioxide. The most common method for achieving this goal is through the injection of slugs of CO2 and water alternatively (i.e., the WAG process). During the WAG process, water reduces the mobility of carbon dioxide; but it also traps oil, increases water flow, and decreases extraction of hydrocarbons from oil by carbon dioxide(1). Another method for reducing the mobility of carbon dioxide is the CO2-foam technique. In this method, a surfactant solution is injected along with carbon dioxide into the reservoir. This combination forms foam in the reservoir, and the presence of foam reduces the mobility of carbon dioxide considerably. However, for any CO2 -foam project, there are challenges that must be met.
Growth of Hydrogenated Amorphous Silicon Films by ArF Excimer Laser Photodissociation of Disilane (1984)

Hydrogenated amorphous silicon films have been grown on glass substrates by photodissociation of disilane using a pulsed ArF excimer laser foe the first time. Electrical and optical properties of the films have been examined. It was found that the magnitude of the gap energy of laser CVD films is rather large as compared to that of films obtained by a conventional plasma CVD. Preliminary examinations to control the conductivity by impurity doping have also been performed.
Specifying Civic Address Extensions in the Presence Information Data Format Location Object (PIDF-LO) (2013)

New fields are occasionally added to civic addresses. A backward-
compatible mechanism for adding civic address elements to the Geopriv
civic address format is described. A formal mechanism for handling
unsupported extensions when translating between XML and DHCP civic
address forms is defined for entities that need to perform this
translation. Initial extensions for some new elements are also
defined. The Location-to-Service Translation (LoST) protocol mechanism
(defined in RFC 5222) that returns civic address element names used
for validation of location information is clarified and is normatively
updated to require a qualifying namespace identifier on each civic
address element returned as part of the validation process.
[STANDARDS-TRACK]