gebhart/patrepeval huggingface dataset:
Involvement of cyclic AMP systems in morphine physical dependence in mice: prevention of development of morphine dependence by rolipram, a phosphodiesterase 4 inhibitor (2001)

In this study, we examined whether morphine dependence was inhibited by rolipram, a cyclic AMP selective phosphodiesterase inhibitor in mice, since a role for the cyclic AMP systems in the development of morphine dependence has been reported. Mice, which received morphine (10 mg kg(-1) s.c.) twice a day for 5 days showed withdrawal syndromes such as jumping, rearing and forepaw tremor following naloxone challenge (5 mg kg(-1) i.p.) on the 6th day. Such mice exhibited a significant elevation of cyclic AMP levels in the thalamus compared to control mice. However, co-administration of rolipram (1 mg kg(-1) i.p.) with morphine for 5 days significantly attenuated the severity of the withdrawal syndrome and the increase in the cyclic AMP levels after the administration of naloxone. In naïve mice, acute morphine treatment (10 mg kg(-1) s.c.) decreased cyclic AMP levels in the thalamus and cerebral cortex 10 min later. The decrease of cyclic AMP levels induced by acute morphine treatment was blocked by co-administration of rolipram (1 mg kg(-1) i.p.). However, acute rolipram did not affect the naloxone-precipitated morphine withdrawal syndrome. These results suggest that the elevation of the cyclic AMP levels is involved in the development of morphine withdrawal syndrome and that blockade of the morphine-induced reduction of cyclic AMP levels by chronic rolipram inhibits the development of dependence and the behavioural and biochemical changes induced by naloxone. Furthermore, rolipram may be a useful drug for attenuating the development of morphine dependence.
Selective inhibition of MBNL1–CCUG interaction by small molecules toward potential therapeutic agents for myotonic dystrophy type 2 (DM2) † (2011)

Myotonic dystrophy type 2 (DM2) is an incurable neuromuscular disease caused by expanded CCUG repeats that may exhibit toxicity by sequestering the splicing regulator MBNL1. A series of triaminotriazine- and triaminopyrimidine-based small molecules (ligands 1-3) were designed, synthesized and tested as inhibitors of the MBNL1-CCUG interaction. Despite the structural similarities of the triaminotriazine and triaminopyrimidine units, the triaminopyrimidine-based ligands bind with low micromolar affinity to CCUG repeats (K(d) ∼ 0.1-3.6 µM) whereas the triaminotriazine ligands do not bind CCUG repeats. Importantly, these simple and small triaminopyrimidine ligands exhibit both strong inhibition (K(i) ∼ 2 µM) of the MBNL1-CCUG interaction and high selectivity for CCUG repeats over other RNA targets. These experiments suggest these compounds are potential lead agents for the treatment of DM2.
In Vitro and In Vivo Effects of Norathyriol and Mangiferin on <i>α</i>-Glucosidase (2017)

Norathyriol is a metabolite of mangiferin. Mangiferin has been reported to inhibit <i>α</i>-glucosidase. To the best of our knowledge, no study has been conducted to determine or compare those two compounds on inhibiting <i>α</i>-glucosidase in vitro and in vivo by far. In this study, we determined the inhibitory activity of norathyriol and mangiferin on <i>α</i>-glucosidase in vitro and evaluated their antidiabetic effect in diabetic mice. The results showed that norathyriol inhibited <i>α</i>-glucosidase in a noncompetitive manner with an IC<sub>50</sub> value of 3.12 <i>μ</i>M, which is more potent than mangiferin (IC<sub>50</sub> = 358.54 <i>μ</i>M) and positive drug acarbose (IC<sub>50</sub> = 479.2 <i>μ</i>M) in the zymological experiment. Both of norathyriol and mangiferin caused significant (<i>p</i> < 0.05) reduction in fasting blood glucose and the blood glucose levels at two hours after carbohydrate loading and it was interesting that mangiferin and norathyriol can make the decline of the blood glucose earlier than other groups ever including normal group in the starch tolerance test. However, norathyriol and mangiferin did not significantly influence carbohydrate absorption in the glucose tolerance test. Therefore, the antidiabetic effects of norathyriol and mangiferin might be associated with <i>α</i>-glucosidase, and norathyriol was more potent than mangiferin.
Tunable bandpass filter based on force-induced long-period fiber grating in a double cladding fiber (2010)

We present an all-fiber tunable bandpass filter based on a combination of a force-induced long-period fiber grating and a fiber coil made along a double cladding fiber. The transmission wavelength can be tuned to be in a range of more than 100 nm by changing the grating period mechanically. We can control the transmission amplitude of the bandpass filter by adjusting the periodic force on the double cladding fiber. The ambient temperature causes a positive shift in the transmission wavelength. Such a device is useful for tunable laser applications and fiber-optic sensors.
Comparison of three methods of assessing muscle strength and imbalance ratios of the knee. (1993)

Three strength measurement methods for determining muscle strength and imbalance ratios of the knee were compared in 41 (23 female, 18 male) NCAA Division I track and field athletes. Peak quadriceps extensions and hamstring flexions were measured isotonically, isometrically, and isokinetically. Isokinetic measurements were performed on a Cybex II at 60 degrees /s. Isometric extension and flexion measurements were performed using the Nicholas Manual Muscle Tester (Lafayette Instruments; Lafayette, Ind). Isotonic measurements were done on both Universal and Nautilus apparatuses. Testing order was randomized to avoid a treatment order effect. A repeated measures ANOVA and a post hoc Tukey test were used to compare the three methods of assessing strength and imbalance ratios of the knee. Absolute strength values were significantly different according to gender and mode of testing. Bilateral strength imbalance ratios for knee flexion were significantly lower for the Nautilus leg curl machine. Ipsilateral strength imbalance ratios were significantly greater for the Cybex II. Our results indicated that absolute strength values cannot be interchanged between testing modes. Except for Cybex II (ipsilateral) and Nautilus (bilateral knee flexion), strength imbalance ratios could be interchanged.
Effect of low concentrations of clavulanic acid on the in-vitro activity of amoxycillin against β-lactamase-producing <i>Branhamella catarrhalis</i> and <i>Haemophilus influenzae</i> (1990)

Concentrations of amoxycillin/clavulanic acid achievable in the respiratory tract following oral dosage were assessed for in-vitro activity against beta-lactamase-producing strains of Branhamella catarrhalis and Haemophilus influenzae. In agar-dilution studies, 8 mg amoxycillin/l was required to inhibit 45 strains of beta-lactamase-producing B. catarrhalis, whereas all the strains were inhibited by 0.5 mg amoxycillin/l in the presence of 0.01 mg clavulanic acid/l. Similarly, 0.1 mg amoxycillin plus 0.05 mg clavulanic acid/l were bactericidal against beta-lactamase-producing strain of B. catarrhalis and prevented regrowth within 24 h. In tests against 43 beta-lactamase-producing strains of H. influenzae, concentrations of up to 128 mg amoxycillin/l were required for inhibition, whereas 32 strains (75%) were fully sensitive to amoxycillin (MIC 0.5 mg/l) in the presence of 0.12 mg clavulanic acid/l. These concentrations of amoxycillin/clavulanic acid were also bactericidal for a beta-lactamase-producing strain of H. influenzae. The study therefore showed that amoxycillin/clavulanic acid, at concentrations similar to those likely to be achieved in the respiratory tract following oral dosage, was bactericidal in vitro for beta-lactamase-producing isolates of B.catarrhalis and H. influenzae.
Mitochondrial neurogastrointestinal encephalomyopathy: An autosomal recessive disorder due to thymidine phosphorylase mutations (2000)

Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an autosomal recessive disorder defined clinically by severe gastrointestinal dysmotility; cachexia; ptosis, ophthalmoparesis, or both; peripheral neuropathy; leukoencephalopathy; and mitochondrial abnormalities. The disease is caused by mutations in the thymidine phosphorylase (TP) gene. TP protein catalyzes phosphorolysis of thymidine to thymine and deoxyribose 1-phosphate. We identified 21 probands (35 patients) who fulfilled our clinical criteria for MNGIE. MNGIE has clinically homogeneous features but varies in age at onset and rate of progression. Gastrointestinal dysmotility is the most prominent manifestation, with recurrent diarrhea, borborygmi, and intestinal pseudo-obstruction. Patients usually die in early adulthood (mean, 37.6 years; range, 26-58 years). Cerebral leukodystrophy is characteristic. Mitochondrial DNA (mtDNA) has depletion, multiple deletions, or both. We have identified 16 TP mutations. Homozygous or compound heterozygous mutations were present in all patients tested. Leukocyte TP activity was reduced drastically in all patients tested, 0.009 +/- 0.021 micromol/hr/mg (mean +/- SD; n = 16), compared with controls, 0.67 +/- 0.21 micromol/hr/mg (n = 19). MNGIE is a recognizable clinical syndrome caused by mutations in thymidine phosphorylase. Severe reduction of TP activity in leukocytes is diagnostic. Altered mitochondrial nucleoside and nucleotide pools may impair mtDNA replication, repair, or both.
From biomass to bio-gasoline by FCC co-processing: effect of feed composition and catalyst structure on product quality (2011)

Due to a worldwide demand for biofuels, a need has emerged to develop new processes. Co-processing of bio-oils in refinery units is a promising alternative, especially by Fluid Catalytic Cracking (FCC). In order to promote biofuel production by co-processing a detailed mechanistic study is required based on comparison with pure vacuum gasoil (VGO) processing. Three different porous materials containing micropores and/or mesopores were tested (FCC, HY and HZSM-5). The co-processing of hydrodeoxygenated pyrolysis oil (HDO-oil) with VGO in a lab test FCC unit leads to lower product formation rates than the processing of VGO alone, except for the coke formation and the formation of more unsaturated components (essentially aromatics). The data for both VGO cracking and co-processing follow the published trends with acid site density. These results are explained by the restricted access of the oxygenated molecules into the zeolite pores and coke formation on the outside surface leading to pore blocking. Another key mechanistic feature, explaining the observed effects of co-processing on the product quality, is the competition for the zeolite acid sites between the cracking route and the deoxygenation of the oxygenated components on the outer surface.
Interferon-α/β inhibition of interleukin 12 and interferon-γ production<i>in vitro</i>and endogenously during viral infection (1997)

Interferon (IFN)-alpha/beta-mediated negative regulation of interleukin 12 (IL-12) and IFN-gamma proteins is reported here. Both IFN-alpha and IFN-beta inhibited fixed Staphylococcus aureus Cowan strain induction of IL-12 and IFN-gamma production by mouse splenic leukocytes in culture. Extended studies with IFN-alpha demonstrated that inhibition was at the level of biologically active IL-12 p70. Effects were selective, as induction of tumor necrosis factor was unaffected and induction of IL-6 was enhanced. Neutralization of IFN-alpha/beta expressed endogenously during infections with murine cytomegalovirus (MCMV) enhanced early IL-12 and IFN-gamma protein production. Furthermore, during infections of mice with lymphocytic choriomeningitis virus (LCMV), this treatment revealed a previously undetected early IL-12 and IFN-gamma protein expression, and mice deficient in IFN-alpha/beta receptor function, but not control mice, also expressed endogenous LCMV-induced IL-12. The effects of IFN-alpha/beta neutralization on production of IL-12 and IFN-gamma during the viral infections were detected in both serum samples and medium conditioned with splenic leukocytes isolated from infected animals. In vitro studies demonstrated that splenic leukocytes isolated from LCMV-infected mice were primed to produce IL-12 in response to stimulation with Staphylococcus aureus Cowan strain, but that this responsiveness was sensitive to added IFN-alpha. Moreover, endogenous IFN-alpha/beta induced by LCMV inhibited in vivo lipopolysaccharide stimulation of IL-12 production. These results demonstrate a new pathway for regulating cytokine responses, and suggest a mechanism for inhibition of IL-12-dependent immune responses during viral infections.
Electrocatalytic Reduction of CO<sub>2</sub> Using the Complexes [Re(bpy)(CO)<sub>3</sub>L]<i><sup>n</sup></i> (<i>n</i> = +1, L = P(OEt)<sub>3</sub>, CH<sub>3</sub>CN; <i>n</i> = 0, L = Cl<sup>-</sup>, Otf<sup>-</sup>; bpy = 2,2‘-Bipyridine; Otf<sup>-</sup> = CF<sub>3</sub>SO<sub>3</sub>) as Catalyst Precursors:  Infrared Spectroelectrochemical Investigation (1996)

This article describes the results of an IR spectroelectrochemical study of the electrocatalytic reduction of carbon dioxide using the complexes [Re(CO)3(bpy)L]n (bpy = 2,2‘-bipyridine; n = 0, L = Cl-, CF3SO3-; n = +1, L = CH3CN, P(OEt)3) as catalyst precursors. The study was performed for the first time with an optically transparent thin-layer electrochemical (OTTLE) cell. The results confirm unambiguously the catalytic activity of the reduced five-coordinate complexes, the radical [Re(CO)3(bpy)]• and the anion [Re(CO)3(bpy)]-. The catalytic behavior of these species could be investigated separately for the first time due to the application of complexes other than those with L = halide, whose catalytic routes may involve simultaneously both radical and anionic catalysis depending on the solvent used. The complex [Re(CO)3(bpy)Cl], so far the most studied catalyst precursor, upon one-electron reduction gives the corresponding radical-anion [Re(CO)3(bpy)Cl]•-, which was previously believed to react directly with CO2. By contrast, this study demonstrates its stability toward attack by CO2, which may only take place after dissociation of the chloride ligand. This conclusion also applies to other six-coordinate radicals [Re(CO)3(bpy)L]• (L = CH3CN (in CH3CN) and P(OEt)3) whose catalytic route requires subsequent one-electron reduction to produce the anionic catalyst [Re(CO)3(bpy)]- (the 2e pathway). The catalytic route of [Re(CO)3(bpy)Cl] in CH3CN therefore deviates from that of the related [Re(CO)3(dmbpy)Cl], the other complex studied by IR (reflectance) spectroelectrochemistry, with the more basic ligand, 4,4‘-dimethyl-2,2‘-bipyridine (dmbpy). The latter complex tends to form the five-coordinate radicals [Re(CO)3(dmbpy)]•, capable of CO2 reduction (the 1e pathway), even in CH3CN, hence eliminating the possibility of the 2e pathway via the anion [Re(CO)3(dmbpy)]-, which operates in the case of the 2,2‘-bipyridine complex. For [Re(CO)3(bpy)L]n (n = 0, L = Cl-, CF3SO3-; n = +1, L = CH3CN), the 1e catalytic route becomes possible in weakly coordinating THF, due to the instability of the radical [Re(CO)3(bpy)(THF)]•. The inherent stability of the radical [Re(CO)3(bpy){P(OEt)3}]• was found convenient for the investigation of the 2e pathway via [Re(CO)3(bpy)]-. The main, spectroscopically observed products of the CO2 reduction are, independent of the 1e and 2e catalytic routes, CO, CO32-, and free CO2H-. The latter product is formed via one-electron reduction of the radical anion [Re(CO)3(bpy)(CO2H)]•-, which is the main byproduct in the catalytic cycle.
Control factor of native oxide growth on silicon in air or in ultrapure water (1989)

Native silicon (Si) oxide growth on Si (100) wafers in air and in ultrapure water at room temperature requires coexistence of water and oxygen in the air and ultrapure water ambients. The growth rate data on n-, n+-, and p+-Si (100) in air indicate layer-by-layer growth of an oxide. The growth rate on n-Si (100) in ultrapure water may be governed by a parabolic law. For native oxide growth in ultrapure water, the number of Si atoms dissolved in ultrapure water is over one order of magnitude larger than the number of Si atoms contained in the grown native oxide film. The structural difference between the native oxide film in air and in ultrapure water is also discussed.
Towards scalable reliability frameworks for error prone CMPs (2009)

As technology scales and the energy of computation continually approaches thermal equilibrium [1,2], parameter variations and noise levels will lead to larger error rates at various levels of the computation stack. The error rates would be especially high for post-CMOS and nanoelectronic systems as well as for probabilistic [3] and stochastic architectures [4]. N-modular redundancy (NMR) at the core-level has been proposed as a way to attain system reliability goals for multicore architectures. While core-level DMR and TMR have been shown to be effective when errors are rare, a large amount of core-level redundancy will be required for attaining system reliability goals in face of high error rates. This makes voting latency and bandwidth significant performance bottlenecks for such systems. In this paper, we present a scalable NMR framework for error prone chip multiprocessors(CMPs). The framework supports in-network fault tolerance where voting logic is integrated into routers to allow for truly distributed voting. The in-network fault tolerance router utilizes the expected redundancy in vote messages, to reduce some of the blocking overhead incurred at the leader, and also provide a mechanism to trade-off network bandwidth with latency. Our framework also supports proactive checkpoint deallocation which allows cores participating in voting to continue on with execution instead of waiting on notification from the voting logic. Finally, the framework supports dynamic constitution that allows an arbitrary core on this chip to be a part of an NMR group. This allows bypassing faulty cores as well as scheduling for performance. Our experiments show significant performance/bandwidth benefits from these optimizations.
Experimental and Theoretical Evidence for Subwavelength Imaging in Phononic Crystals (2009)

We show experimentally and theoretically that super resolution can be achieved while imaging with a flat lens consisting of a phononic crystal exhibiting negative refraction. This phenomenon is related to the coupling between the incident evanescent waves and a bound slab mode of the phononic crystal lens, leading to amplification of evanescent waves by the slab mode. Super resolution is only observed when the source is located very near to the lens, and is very sensitive to the location of the source parallel to the lens surface as well as to site disorder in the phononic crystal lattice.
Nitazoxanide pharmacokinetics and tolerability in man during 7 days dosing with 0.5 g and 1 g b.i.d. (2002)

Oral administration of 0.5 g of nitazoxanide b.i.d. for 7 days with food in healthy volunteers is well-tolerated and is not associated with any significant accumulation of T or TG. A higher 1 g dose results in an increased frequency of gastrointestinal discomfort and is associated with significant accumulation of T and TG.
O<sup>6</sup>-Methylguanine-DNA Methyltransferase Expression Strongly Correlates With Outcome in Childhood Malignant Gliomas: Results From the CCG-945 Cohort (2006)

Overexpression of MGMT in childhood malignant gliomas is strongly associated with an adverse outcome in children treated with alkylator-based chemotherapy, independently of a variety of clinical prognostic factors.
The effect of glucocorticoids on osteoblast function. The effect of corticosterone on osteoblast expression of beta 1 integrins. (1995)

Prolonged treatment with glucocorticoids is known to produce osteoporosis, which is characterized by a decrease in bone mass. Therefore, we studied the effect of glucocorticoids on the formation of bone and on the expression of beta 1 integrins in a mineralizing organ culture of fetal rat parietal bone. Integrins are a family of integral membrane glycoproteins that mediate the adhesion of cells to extracellular matrix macromolecules and affect the growth and differentiation of cells. In situ hybridization with a 32P-labeled beta 1 integrin cDNA probe was performed on parietal bone, treated with or without 100-nanomolar corticosterone for ninety-six hours, to localize and assess the levels of beta 1 integrin mRNA quantitatively. Corticosterone decreased beta 1 integrin mRNA in the osteoblast layer but not in the periosteum. Northern blot analysis demonstrated a 62 per cent decrease in the levels of beta 1 integrin mRNA in the osteoblast layer of bone that had been stripped of its periosteum. Immunofluorescence microscopy confirmed these results, as they demonstrated a decrease in the levels of beta 1 integrin protein predominantly in the osteoblast layer. This effect was dependent on the concentration of corticosterone. During ninety-six hours of culture, the calcium content and the dry weight of control parietal bone increased 157 per cent and 57 per cent, respectively. However, treatment of these cultures with 100-nanomolar corticosterone inhibited calcification by 24 per cent. The administration of glucocorticoid had no significant effect on the DNA content or dry weight.(ABSTRACT TRUNCATED AT 250 WORDS)
Aperture averaging of the two-wavelength intensity covariance function in atmospheric turbulence (1985)

The influence of aperture averaging on the two-wavelength intensity covariance function was experimentally determined for visible (0.63 microm) and infrared (1.06 microm) collinear, approximately spherical beams which propagated through the earth's turbulent atmosphere. Range varied from 1300 to 3250 m, and due to the prevailing atmospheric conditions, most measurements were made in the strong turbulence regimes. Results show that (1) the covariance function monotonically decreases as the receiver aperture size increases; (2) the correlation coefficient attains high values > or = 0.7) even for a relatively small aperture size of 5 mm; (3) while the single wavelength probability distribution of the intensity is approximately lognormal, the experimental two-wavelength conditional probabilities are higher than those predicted by the lognormal model.
The use of vehicle acceleration measurements to estimate road roughness (2008)

Road roughness is a broad term that incorporates everything from potholes and cracks to the random deviations that exist in a profile. To build a roughness index, road irregularities need to be measured first. Existing methods of gauging the roughness are based either on visual inspections or using one of a limited number of instrumented vehicles that can take physical measurements of the road irregularities. This paper proposes the collection of data from accelerometers fixed in a specific vehicle type and the use of this data to estimate the road condition. Although the estimate is approximate, accelerometers are being increasingly used by car manufacturers to improve suspension performance and the proposed method is relatively inexpensive to implement and provide road managers with constantly updated measurements of roughness. This approach is possible due to the relationship between the power spectral densities of road surface and vehicle accelerations via a transfer function. This paper shows how road profiles can be accurately classified using axle and body accelerations from a range of simulated vehicle–road dynamic scenarios.