gebhart/patrepeval huggingface dataset:
Protective effect of far-infrared treated rice hull extract on lipid peroxidation in phospholipid bilayer (2011)

The protective effect of methanolic extract of far-infrared treated rice hull (FRH) on phospholipid peroxidation of liposome was compared with that of natural antioxidants (ascorbic acid, morin, quercetin and α-tocopherol). With induction of phopholipid peroxidation by 2,2’-azobis (2-amidinopropane), dihydrochloride (a water-soluble radical generator), 2,2’-azobis (2,4-dimethylvaleronitrile) (a lipid-soluble radical generator) and transition metal ions (Fe3+ and Cu2+), the phospholipid peroxidation was investigated for 6 h at 37 and 50°C. The added antioxidants prevent peroxidation of phospholipid in liposome, and FRH showed the strongest antioxidant activity in all cases. The results indicate that FRH showed significant antioxidant activity on lipid peroxidation in hydrophilic as well as hydrophobic conditions regardless of hydrophobicity of radical generators and transition metals.

	 

	Key words: Far-infrared treated rice hull, liposome, peroxidation, antioxidant activity.
A Combinatorial Method for Solution-Phase Synthesis of Labeled Bivalent β-Turn Mimics (2007)

Piperidine-functionalized, 1,4-disubstituted-1,2,3-triazoles of generic structure 1 were conceived as "minimalist" mimics of peptidic beta-turn structures. Key features of these molecules include (i) the possibility of incorporating amino acid side chains corresponding to many of the protein amino acids; (ii) a close correspondence of separations of these side chains to i + 1 to i + 2 residues in turns; (iii) facile adjustment of the side-chain vectors on docking while only influencing two critical degrees of freedom; and (iv) some electrostatic polarity. Fifteen monomers of this type were made via copper-mediated cycloaddition reactions. Solution-phase methodologies were devised to assemble these monomers into bivalent compounds in high purity states (typically >85%) so that they could be used in first-pass biological assays without further purification. The skeleton for forming these bivalent compounds is triazine-based. There is a third site which allowed for introduction of a fluorescent label (library of compounds 2) or an alkyne-functionalized triethylene glycol chain (library of compounds 3) included to promote water-solubility and to allow incorporation of probes via copper-mediated cycloaddition reactions. In the event, two 135-membered libraries were prepared, one consisting of compounds 2 and the other of 3. No protecting groups or coupling agents were required; these attributes of the method were important to allow most of the products to be obtained in over 85% purities. The fluorescein-tagged library of compounds 2 was screened in a fluorescence-activated cell sorting (FACS) assay using cells transfected to overexpress one of the following neurotrophin receptors: TrkA, TrkC, and p75. Preliminary findings indicate four compounds 2gm, 2gn, 2gi, and 2gj bound the TrkA receptor selectively; all of these contain a threonine-lysine turn mimic. Thus, a pharmacological probe for the TrkA receptor has been developed.
Generalized Method and Monitoring Technique for Shear-Strain-Based Bridge Weigh-in-Motion (2015)

Development and testing of a new type of bridge weigh-in-motion system (BWIM) based on the measurement of shear forces near the supports of the bridges is described. The proposed system is applicable to both determinate as well as indeterminate bridges. Fiber-optic Bragg grating rosette sensors were used in this approach. Formulations are based on the establishment of shear influence lines in terms of axle weights and spacings. The system further involves calibration for the estimation of a bridge parameter α, which is a function of the cross-sectional and material properties of the bridge. Three different bridges, one box-girder prestressed concrete bridge and two concrete-slab-on-steel-girder bridges with different span lengths, were instrumented for the evaluation of the proposed BWIM system. Field implementation involved a series of truck runs for calibration and evaluation of the BWIM system. Measured and actual truck-axle weights, spacings, and axle speeds as well as the gross vehicle weights yielded comparable results.
A phenotypically and functionally distinct human T <sub>H</sub> 2 cell subpopulation is associated with allergic disorders (2017)

Allergen-specific type 2 helper T (T<sub>H</sub>2) cells play a central role in initiating and orchestrating the allergic and asthmatic inflammatory response pathways. One major factor limiting the use of such atopic disease-causing T cells as both therapeutic targets and clinically useful biomarkers is the lack of an accepted methodology to identify and differentiate these cells from overall nonpathogenic T<sub>H</sub>2 cell types. We have described a subset of human memory T<sub>H</sub>2 cells confined to atopic individuals that includes all allergen-specific T<sub>H</sub>2 cells. These cells are terminally differentiated CD4<sup>+</sup> T cells (CD27<sup>-</sup> and CD45RB<sup>-</sup>) characterized by coexpression of CRT<sub>H</sub>2, CD49d, and CD161 and exhibit numerous functional attributes distinct from conventional T<sub>H</sub>2 cells. Hence, we have denoted these cells with this stable allergic disease-related phenotype as the T<sub>H</sub>2A cell subset. Transcriptome analysis further revealed a distinct pathway in the initiation of pathogenic responses to allergen, and elimination of these cells is indicative of clinical responses induced by immunotherapy. Together, these findings identify a human T<sub>H</sub>2 cell signature in allergic diseases that could be used for response-monitoring and designing appropriate immunomodulatory strategies.
Comparative evaluation of dural venous sinuses and cerebral veins using contrast-enhanced spoiled gradient recalled echo and time-of-flight magnetic resonance venography (2019)

AbstractBackground/Aims:In the present study, dural venous sinuses and cerebral veins were examined using 3D SPGR MRV and 2D TOF MRV. These methods were compared in terms of detectability of venous structures and their diameters. Methods:A total of 110 patients(66 female and 44 male) who had contrast-enhanced 3D SPGR MRV and 2D TOF MRV examinations using a 1.5 T MRI machine in May 2008-June 2011 period were included in the present study. Diameters of dural venous sinuses and veins were measured at three different planes at a position 1cm distal to the site they drained into, and average values were used. Both MRV methods were compared to reveal whether the diameters calculated were different in age groups and between genders.Results:SSS, bilateral TS’s, right sigmoid sinus, Galen vein and bilateral ICV’s all could be determined using 3D SPGR MRV. Not all dural venous sinuses and veins other than right sigmoid sinus could be visualized in all patients using 2D TOF MRV.There were significant differences between the two examinations for SSS and ISS, bilateral TS and sigmoid sinuses, SS, bilateral Labbe and ICV and Galen vein diameters(p&lt;0.05) Diameters of dural venous sinuses and cortical veins were generally measured larger by 3D SPGR MRV compared to 2D TOF MRV.Conclusions:In conclusion, differences could be observed between the two MRV examinations for detectability and diameters of intracranial venous structures. Evaluation of intracranial venous structures should not be carried out using only 2D TOF MRV.
Regulatory genes in the thermoregulation of Escherichia coli pili gene transcription. (1989)

Expression of several different pilus adhesins by Escherichia coli is subject to thermoregulation. The surface-located fimbrial structures are present during growth at 37 degrees C but are not produced by cells grown at lower temperatures, such as 25 degrees C. As a step toward understanding the molecular mechanism, we have studied the role of different cistrons of a cloned pilus adhesin gene cluster (pap) from a uropathogenic E. coli isolate. By promoter cloning, mRNA analysis, and expression of subcloned genes in trans, we have identified the papI gene as the mediator of thermoregulation at the level of pilus adhesin gene transcription. Expression of the major pilus subunit gene (papA) and several other pilus protein cistrons appeared to be dependent on stimulation by the papB and papI gene products. Constructs carrying different pap DNA regions indicated that none of the known Pap proteins acts directly as thermosensor. The chromosomal rpoH gene and RpoH sigma factor did not appear to be required for pap transcription, and the thermoregulation of pilus gene transcription must be different from that of the heat shock regulon. By overexpressing the papI gene product from an expression plasmid in trans, we could circumvent the temperature regulation and turn on production of pilus adhesin at low temperature. Our results suggest that the level of mRNA encoding the PapI activator is limiting at low growth temperatures and that thermoregulation is due to a determinant in the papI-papB intercistronic region.
Using AutoCAD 2000 (1999)

From the Publisher:
Now in its 10th edition, Using AutoCAD 2000 makes using AutoCAD a snap by presenting you with easy - to - master, step - by - step tutorials through all the commands of AutoCAD. Using AutoCAD is designed to lead the novice through the basics of AutoCAD to more advanced features like customizing, 3D, and AutoLISP.
Using AutoCAD 2000 will be one of the first books available on AutoCAD 2000 and Autodesk Press will be the only AutoCAD publisher offering a Free 30 day trial version of AutoCAD 2000 included in a CD - ROM in the back of most of our AutoCAD 2000 titles! The CD - ROM will contain fully functional AutoCAD 2000 software (no student watermark or hardware lock!) which will expire 30 days after initial installation. Also included on the CD - ROM are drawing files, which can be used with AutoCAD 2000.
A quantitative numerical model of multilayer vapor-deposited organic light emitting diodes (1999)

A one-dimensional numerical model for the quantitative simulation of multilayer organic light emitting diodes (OLEDs) is presented. It encompasses bipolar charge carrier drift with field-dependent mobilities and space charge effects, charge carrier diffusion, trapping, bulk and interface recombination, singlet exciton diffusion and quenching effects. Using field-dependent mobility data measured on unipolar single layer devices, reported energetic levels of highest occupied and lowest unoccupied molecular orbitals, and realistic assumptions for experimentally not direct accessible parameters, current density and luminance of state-of-the-art undoped vapor-deposited two- and three-layer OLEDs with maximum luminance exceeding 10000 cd/m2 were successfully simulated over 4 orders of magnitude. For an adequate description of these multilayer OLEDs with energetic barriers at interfaces between two adjacent organic layers, the model also includes a simple theory of charge carrier barrier crossing and recombination at organic–organic interfaces. The discrete nature of amorphous molecular organic solids is reflected in the model by a spatial discretization according to actual molecule monolayers, with hopping processes for charge carrier and energy transport between neighboring monolayers.
Urinary properdin excretion is associated with intrarenal complement activation and poor renal function (2009)

Our results suggest that urinary properdin excretion enhances intrarenal complement activation and thus may contribute to the progression of renal damage in proteinuric states.
A cytomegalovirus protein with properties of herpes simplex virus ICP8: partial purification of the polypeptide and map position of the gene (1987)

We demonstrated the presence of a single-stranded DNA-binding protein in human cytomegalovirus (CMV)-infected cells with properties analogous to those of herpes simplex virus (HSV) ICP8. Using monoclonal antibody specific for the CMV protein, we analyzed its fluorescence pattern and time of synthesis, mapped the gene encoding it by using a lambda gt11 library of CMV DNA fragments, and monitored its purification by phosphocellulose and DNA-Sepharose chromatography. In all characteristics we examined, the CMV protein behaved analogously to HSV ICP8. Our results are consistent with a functional role of CMV ICP8 in viral replication that is similar to that of HSV ICP8 and with the evolutionary conservation of the gene of interest in two divergent herpesviruses.
Effect of Gingival Margin Design on Retention of Thermoformed Orthodontic Aligners (2020)

Purpose: The aim of this study was evaluate the effect of gingival margin design (scalloped vs. straight cut at gingival zenith vs. straight cut 2mm above gingival zenith) on the retention of thermoformed aligners. Retention of aligners is a critical requirement for efficient tooth movement. Methods: Two thermoform aligner materials were used, Invisacryl A and Invisacryl C, in 0.040 mil (1mm) thickness. Six aligner designs were fabricated for each of the two aligner materials (12 total aligner designs). Aligner designs are scalloped, straight cut at gingival zenith (0mm), and straight cut 2mm above gingival zenith on a model with attachments. These designs were tested with and without attachments. Three aligners were made for each of the 12 aligner designs for a total of 36 aligners. A Universal Testing Machine was used to pull each aligner off of a Kilgore dentoform in a direction perpendicular to the occlusal plane. The force needed to pull each aligner off of the dentoform was recorded as the retentive force of the aligner. A one way ANOVA with a Post Hoc Bonferroni test was completed on the average pull off force for each of the 12 aligner groups. Results: Of the 66 comparisons made 57 had significant differences when comparing each aligner group's average retentive pull off force. The highest retentive force was Invisacryl A, 2mm straight margin, with attachments while the lowest retentive force was Invisacryl C, scalloped with attachments. Conclusions: Invisacryl A material showed increased retention when compared to Invisacryl C material of the same aligner margin and attachment design. Straight line gingival margins (0 and 2mm) showed and increased retention when compared to scalloped margins for Invisacryl A and Invisacryl C with attachments. Aligners with attachments and scalloped margins had significantly less retention than aligners of the same material type with scalloped margins and no attachments. The 2mm straight gingival margin design had the highest retentive forces when compared to aligners of the same material and attachment type.
Induction of interleukin-8 (CXCL-8) by tumor necrosis factor-α and leukemia inhibitory factor in pancreatic carcinoma cells: Impact of CXCL-8 as an autocrine growth factor (2007)

Pancreatic carcinoma is one of the most lethal of the gastrointestinal malignant tumors. Chronic inflammation leads to cancer development and progression. Interleukin-8 (CXCL-8) is a CXC chemokine, which plays an important role in neutrophil chemotaxis and activation. We previously reported that CXCL-8 was produced by a variety of human carcinoma cells and tissues, and that CXCL-8 promoted proliferation in pancreatic carcinoma cells (SUIT-2). In the present study, we analyzed whether various cytokines affect cell proliferation by CXCL-8 expression in pancreas carcinoma cells. All examined pancreatic carcinoma cells expressed CXCL-8 and TNFRII mRNA constitutively in RPMI-1640 medium without FBS. TNF-alpha, LIF, IL-1beta, IL-6, IL-8, or IFN-beta enhanced the expression of CXCL-8 mRNA, but IL-10 did not in Hs-700T cells. Actinomycin D suppressed and cycloheximide augmented CXCL-8 mRNA which was induced by TNF-alpha or not. The half-life of CXCL-8 mRNA was 36.5 min by TNF-alpha and 35.2 min by no stimulation. In our previous study, LIF promoted cell growth in Hs-700T cells. LIF induced CXCL-8 mRNA in a dose- and time-dependent manner. Addition of recombinant CXCL-8 did not induce cell growth of Hs-700T. Anti-CXCL-8 IgG significantly suppressed cell growth. CXCL-8 would act as an autocrine growth factor in Hs-700T cells, which expressed CXCL-8 mRNA highly without stimulation. Curcumin (diferuloylmethane), NF-kappaB inhibitor, suppressed cell proliferation in Hs-700T cells. These results suggest that CXCL-8 plays a pivotal role in progression of pancreatic cancer, and its expression is influenced by inflammatory cytokines in pancreatic tumor microenvironment.
Silyl halides from (phenylseleno)silanes. Reaction with oxiranes and alcohols to give hydrolytically stable silyl ethers (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSilyl halides from (phenylseleno)silanes. Reaction with oxiranes and alcohols to give hydrolytically stable silyl ethersMichael R. Detty and Mark D. SeidlerCite this: J. Org. Chem. 1981, 46, 7, 1283–1292Publication Date (Print):March 1, 1981Publication History Published online1 May 2002Published inissue 1 March 1981https://doi.org/10.1021/jo00320a012RIGHTS & PERMISSIONSArticle Views2026Altmetric-Citations64LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alerts Get e-Alerts
Role of Arginine Vasopressin in Regulation of Systemic Arterial Pressure (1986)

Arginine vasopressin (AVP) not only influences renal water metabolism but also has profound cardiovascular effects. Physiologic levels of the hormone produce a pressor response in the basal state when vasoregulatory reflex mechanisms are interrupted. During hypovolemia, vasopressin affects systemic blood pressure independent of the renin-angiotensin system and efferent sympathetic pathways. Many studies implicate AVP in the pathogenesis of hypertension, but the actual mechanism and relative importance of vasopressin's role remain a matter of intense investigation.
Study on Cleaning Technology of Municipal Solid Waste Landfill Gas (LFG) (2009)

Landfill gas (LFG) generated in municipal solid waste (MSW) landfills, which mainly contains CH <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> and CO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> , contributes to greenhouse effect and environmental degradation on the one hand, and constitutes a useful energy on the other hand due to its rich composition of methane. With this in mind, this study explored a new cleaning technology of LFG for the convenience of its application. In this study, chemical cleaning process was selected to remove CO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> and H <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> S from LFG and polyamine solution used at normal pressure, to study the influence of operating parameters on removal of CO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> and H <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> S. It was found that CO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> and H <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> S can be removed effectively from LFG and recovery rate of methane exceeds 99% under the following conditions: gas-liquid ratio between 12 and 40 (v/v), temperature of absorption column between 40 and 80 centigrade Celsius, temperature of stripping column between 85 and 120 centigrade Celsius. After this cleaning process, content of methane in the cleaned LFG (CLFG) exceeds 96%, and that of CO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> and H <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> S is less than 3% and 1 mg/m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> respectively. In addition, heating value of the CLFG exceeds 38 MJ/m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> . Consequently, quality of the CLFG meet requirements of natural gas for vehicles and domestic use, yielding considerable economic and environmental benefits.
Incoherent coding techniques and performance characterization for multibeam sonar systems (2003)

A sonar imaging technique which uses specially coded waveforms to project different sound signals in different directions was previously proposed. In this context, the problem of creating a set of frequency-hopped code words that have mutually small correlation properties has arisen. The authors report on their progress in designing these frequency-hopped signals for multibeam sonar imaging. The special case is considered in which medium spreading effects destroy the phase coherence of the imaging system. A design strategy is discussed which has allowed the design of a set of frequency-hopped code words that exhibit good performance bounds with respect to incoherent processing. The design strategy is a systematic constructions technique which can be used with any size Galois field GF(p) to generate p-1 codes of length p. Various theorems are presented and examples of the performance of the technique are illustrated for time-bandwidth products of interest in terms of sonar.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Further examination of the effects of recombinant cytokines on the proliferation of human megakaryocyte progenitor cells (1991)

The effect of several recombinant cytokines, including interleukin-3 (IL-3), granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-6, and IL-1 alpha, on megakaryocyte (MK) colony formation by a normal human bone marrow subpopulation (CD34+ DR+), enriched for the MK colony-forming unit (CFU-MK), was studied using a serum-depleted, fibrin clot culture system. IL-3 and GM-CSF, but not IL-6 or IL-1 alpha, stimulated MK colony formation by CD34+ DR+ cells. However, the addition of IL-1 alpha to CD34+ DR+ cultures containing IL-6 resulted in the appearance of CFU-MK-derived colonies, suggesting that IL-6 requires the presence of IL-1 alpha to exhibit its MK colony-stimulating activity (MK-CSA). Addition of neutralizing antibodies to IL-3 and GM-CSF, but not to IL-6 and IL-1 alpha, specifically inhibited the MK-CSA of IL-3 and GM-CSF, respectively. The addition of either anti-IL-6, anti-IL-1 alpha, or anti-IL-3 antisera to cultures containing both IL-6 and IL-1 alpha totally abolished the MK-CSA of the IL-6/IL-1 alpha combination. However, neither anti-IL-3 nor anti-GM-CSF antisera could totally neutralize the additive effect of the combination of IL-3 and GM-CSF on MK colony formation, indicating that these two cytokines act by affecting distinct effector pathways. These results suggest that while IL-3 and GM-CSF can directly affect CFU-MK-derived colony formation, IL-1 alpha and IL-6 act in concert to promote de novo elaboration of IL-3 and thereby promote CFU-MK proliferative capacity.